gene_id BaseMean BaseMean_control_NC BaseMean_case_circXRN2 FoldChange log2FoldChange p-value q-value Expression_NC Expression_circXRN2 gene_Dbxref description GO_id GO_term pathway pathway_description TF_family A4GALT 454.6538778 429.6909335 479.616822 1.11619023 0.158582924 0.57473731 1 6.326018037 6.942882595 53947 "alpha 1,4-galactosyltransferase (P blood group)" "GO:0001576,GO:0006688,GO:0007009,GO:0008378,GO:0015643,GO:0016020,GO:0016758,GO:0030173,GO:0050512" "globoside biosynthetic process|glycosphingolipid biosynthetic process|plasma membrane organization|galactosyltransferase activity|toxic substance binding|membrane|transferase activity, transferring hexosyl groups|integral component of Golgi membrane|lactosylceramide 4-alpha-galactosyltransferase activity" "hsa00601,hsa00603" Glycosphingolipid biosynthesis - lacto and neolacto series|Glycosphingolipid biosynthesis - globo and isoglobo series AAAS 1076.928862 1109.081199 1044.776524 0.942019868 -0.086170608 0.726963693 1 32.53965101 30.14006133 8086 aladin WD repeat nucleoporin "GO:0000922,GO:0001578,GO:0003674,GO:0005515,GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005813,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006913,GO:0007612,GO:0009566,GO:0016020,GO:0016032,GO:0016925,GO:0019083,GO:0031965,GO:0043657,GO:0046822,GO:0060964,GO:0072686,GO:0075733,GO:0090307,GO:1900034" spindle pole|microtubule bundle formation|molecular_function|protein binding|nucleus|nuclear envelope|nuclear pore|nucleoplasm|centrosome|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|nucleocytoplasmic transport|learning|fertilization|membrane|viral process|protein sumoylation|viral transcription|nuclear membrane|host cell|regulation of nucleocytoplasmic transport|regulation of gene silencing by miRNA|mitotic spindle|intracellular transport of virus|mitotic spindle assembly|regulation of cellular response to heat hsa03013 RNA transport AACS 872.2145469 781.3508259 963.0782679 1.23258111 0.301682586 0.226215588 1 12.4586966 15.09938629 65985 acetoacetyl-CoA synthetase "GO:0001889,GO:0005515,GO:0005524,GO:0005829,GO:0006631,GO:0007584,GO:0014074,GO:0030729,GO:0032024,GO:0034201,GO:0042493,GO:0042594,GO:0045471,GO:0046951,GO:0047760,GO:0050872,GO:0060612,GO:0071333,GO:0071394,GO:0071397" liver development|protein binding|ATP binding|cytosol|fatty acid metabolic process|response to nutrient|response to purine-containing compound|acetoacetate-CoA ligase activity|positive regulation of insulin secretion|response to oleic acid|response to drug|response to starvation|response to ethanol|ketone body biosynthetic process|butyrate-CoA ligase activity|white fat cell differentiation|adipose tissue development|cellular response to glucose stimulus|cellular response to testosterone stimulus|cellular response to cholesterol "hsa00280,hsa00650" "Valine, leucine and isoleucine degradation|Butanoate metabolism" AADAC 60.55724126 88.43518002 32.6793025 0.369528309 -1.436243205 0.01103599 0.623624625 2.824430294 1.026241927 13 arylacetamide deacetylase "GO:0003824,GO:0004806,GO:0005515,GO:0005789,GO:0006805,GO:0010898,GO:0016021,GO:0016298,GO:0016787,GO:0017171,GO:0019213" catalytic activity|triglyceride lipase activity|protein binding|endoplasmic reticulum membrane|xenobiotic metabolic process|positive regulation of triglyceride catabolic process|integral component of membrane|lipase activity|hydrolase activity|serine hydrolase activity|deacetylase activity AADAT 198.3139299 210.1636043 186.4642555 0.88723381 -0.17261375 0.644397493 1 4.043275161 3.527301311 51166 aminoadipate aminotransferase "GO:0005759,GO:0006103,GO:0006536,GO:0006554,GO:0006569,GO:0008483,GO:0009058,GO:0016212,GO:0030170,GO:0033512,GO:0042803,GO:0047536,GO:0070189,GO:0097052,GO:1901605" mitochondrial matrix|2-oxoglutarate metabolic process|glutamate metabolic process|lysine catabolic process|tryptophan catabolic process|transaminase activity|biosynthetic process|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding|L-lysine catabolic process to acetyl-CoA via saccharopine|protein homodimerization activity|2-aminoadipate transaminase activity|kynurenine metabolic process|L-kynurenine metabolic process|alpha-amino acid metabolic process "hsa00310,hsa00380" Lysine degradation|Tryptophan metabolism AAGAB 1076.022426 1072.666713 1079.378139 1.006256767 0.008998485 0.974874827 1 15.44691068 15.283458 79719 alpha and gamma adaptin binding protein "GO:0005515,GO:0005737,GO:0005829,GO:0015031,GO:0016607" protein binding|cytoplasm|cytosol|protein transport|nuclear speck AAK1 870.489151 988.3931885 752.5851135 0.761422804 -0.393230316 0.114452292 1 2.494029687 1.8672337 22848 AP2 associated kinase 1 "GO:0004674,GO:0005112,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005905,GO:0006468,GO:0006897,GO:0019897,GO:0030136,GO:0031252,GO:0032880,GO:0035612,GO:0043195,GO:0045747,GO:0046777,GO:0050821,GO:0061024,GO:0106310,GO:0106311,GO:2000369" protein serine/threonine kinase activity|Notch binding|protein binding|ATP binding|cytoplasm|cytosol|clathrin-coated pit|protein phosphorylation|endocytosis|extrinsic component of plasma membrane|clathrin-coated vesicle|cell leading edge|regulation of protein localization|AP-2 adaptor complex binding|terminal bouton|positive regulation of Notch signaling pathway|protein autophosphorylation|protein stabilization|membrane organization|protein serine kinase activity|protein threonine kinase activity|regulation of clathrin-dependent endocytosis AAMDC 274.9535413 241.3760208 308.5310619 1.278217533 0.354133382 0.276648878 1 7.257349069 9.12124165 28971 adipogenesis associated Mth938 domain containing "GO:0005515,GO:0005737,GO:0045600" protein binding|cytoplasm|positive regulation of fat cell differentiation AAMP 1869.7348 1773.90567 1965.56393 1.108043096 0.148013994 0.532927208 1 53.6374421 58.43807336 14 angio associated migratory cell protein "GO:0001525,GO:0005515,GO:0005829,GO:0005886,GO:0008201,GO:0009986,GO:0010595,GO:0014909,GO:0015630,GO:0030154,GO:0045171" angiogenesis|protein binding|cytosol|plasma membrane|heparin binding|cell surface|positive regulation of endothelial cell migration|smooth muscle cell migration|microtubule cytoskeleton|cell differentiation|intercellular bridge AAR2 808.5599873 826.0886228 791.0313518 0.957562336 -0.062561687 0.807646237 1 13.79869531 12.9920074 25980 AAR2 splicing factor "GO:0000244,GO:0005681,GO:0005682" spliceosomal tri-snRNP complex assembly|spliceosomal complex|U5 snRNP AARS1 8109.734641 9588.454342 6631.01494 0.691562446 -0.532068566 0.031533586 0.904158095 148.8851281 101.240411 16 alanyl-tRNA synthetase 1 "GO:0000049,GO:0002161,GO:0002196,GO:0004813,GO:0005524,GO:0005737,GO:0005739,GO:0005829,GO:0006400,GO:0006418,GO:0006419,GO:0008033,GO:0008270,GO:0016020,GO:0016597,GO:0070062,GO:0106074" tRNA binding|aminoacyl-tRNA editing activity|Ser-tRNA(Ala) hydrolase activity|alanine-tRNA ligase activity|ATP binding|cytoplasm|mitochondrion|cytosol|tRNA modification|tRNA aminoacylation for protein translation|alanyl-tRNA aminoacylation|tRNA processing|zinc ion binding|membrane|amino acid binding|extracellular exosome|aminoacyl-tRNA metabolism involved in translational fidelity hsa00970 Aminoacyl-tRNA biosynthesis AARS2 330.2885915 369.3469283 291.2302547 0.788500546 -0.342816341 0.262538262 1 3.743138385 2.902077863 57505 "alanyl-tRNA synthetase 2, mitochondrial" "GO:0000049,GO:0002161,GO:0004813,GO:0005515,GO:0005524,GO:0005739,GO:0006400,GO:0006419,GO:0008270,GO:0016597,GO:0070143,GO:0106074" tRNA binding|aminoacyl-tRNA editing activity|alanine-tRNA ligase activity|protein binding|ATP binding|mitochondrion|tRNA modification|alanyl-tRNA aminoacylation|zinc ion binding|amino acid binding|mitochondrial alanyl-tRNA aminoacylation|aminoacyl-tRNA metabolism involved in translational fidelity hsa00970 Aminoacyl-tRNA biosynthesis AASDH 434.5438302 444.2567279 424.8309325 0.956273492 -0.06450481 0.826975871 1 5.010389911 4.711127089 132949 aminoadipate-semialdehyde dehydrogenase "GO:0005524,GO:0006631,GO:0016878,GO:0019482,GO:0043041" ATP binding|fatty acid metabolic process|acid-thiol ligase activity|beta-alanine metabolic process|amino acid activation for nonribosomal peptide biosynthetic process AASDHPPT 1212.168804 1215.203415 1209.134193 0.995005591 -0.007223462 0.980007625 1 14.41501952 14.10301392 60496 aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase "GO:0000287,GO:0005515,GO:0005829,GO:0008897,GO:0015939,GO:0019878,GO:0070062" magnesium ion binding|protein binding|cytosol|holo-[acyl-carrier-protein] synthase activity|pantothenate metabolic process|lysine biosynthetic process via aminoadipic acid|extracellular exosome hsa00770 Pantothenate and CoA biosynthesis AASS 1149.198612 1151.738168 1146.659056 0.995590046 -0.006376289 0.983098453 1 10.54307877 10.32093815 10157 aminoadipate-semialdehyde synthase "GO:0000122,GO:0003714,GO:0004753,GO:0004754,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006554,GO:0019878,GO:0031061,GO:0033512,GO:0042393,GO:0043231,GO:0047130,GO:0047131,GO:0055114" "negative regulation of transcription by RNA polymerase II|transcription corepressor activity|saccharopine dehydrogenase activity|saccharopine dehydrogenase (NAD+, L-lysine-forming) activity|nucleus|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|lysine catabolic process|lysine biosynthetic process via aminoadipic acid|negative regulation of histone methylation|L-lysine catabolic process to acetyl-CoA via saccharopine|histone binding|intracellular membrane-bounded organelle|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|oxidation-reduction process" hsa00310 Lysine degradation AATF 1977.278628 2036.089968 1918.467288 0.942231099 -0.085847145 0.718207764 1 52.6975652 48.82240428 26574 apoptosis antagonizing transcription factor "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005737,GO:0005794,GO:0006357,GO:0006974,GO:0007155,GO:0007346,GO:0019901,GO:0032929,GO:0040016,GO:0042254,GO:0042985,GO:0043066,GO:0043522,GO:0045944,GO:0048156,GO:2000378,GO:2001234" RNA binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytoplasm|Golgi apparatus|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|cell adhesion|regulation of mitotic cell cycle|protein kinase binding|negative regulation of superoxide anion generation|embryonic cleavage|ribosome biogenesis|negative regulation of amyloid precursor protein biosynthetic process|negative regulation of apoptotic process|leucine zipper domain binding|positive regulation of transcription by RNA polymerase II|tau protein binding|negative regulation of reactive oxygen species metabolic process|negative regulation of apoptotic signaling pathway AATK 11.25143831 5.202069413 17.30080721 3.325754778 1.733681797 0.123761254 1 0.05034909 0.1646467 9625 apoptosis associated tyrosine kinase "GO:0004672,GO:0004713,GO:0005515,GO:0005524,GO:0005575,GO:0006468,GO:0007420,GO:0008150,GO:0016021,GO:0038083,GO:0048471,GO:0106310,GO:0106311" protein kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|cellular_component|protein phosphorylation|brain development|biological_process|integral component of membrane|peptidyl-tyrosine autophosphorylation|perinuclear region of cytoplasm|protein serine kinase activity|protein threonine kinase activity ABAT 4.082397604 6.242483296 1.922311912 0.307940257 -1.699277611 0.406294648 1 0.057291464 0.017347127 18 4-aminobutyrate aminotransferase "GO:0003867,GO:0005739,GO:0005759,GO:0009448,GO:0009450,GO:0030170,GO:0032144,GO:0032145,GO:0034386,GO:0042135,GO:0042802,GO:0046872,GO:0047298,GO:0048148,GO:0051536" 4-aminobutyrate transaminase activity|mitochondrion|mitochondrial matrix|gamma-aminobutyric acid metabolic process|gamma-aminobutyric acid catabolic process|pyridoxal phosphate binding|4-aminobutyrate transaminase complex|succinate-semialdehyde dehydrogenase binding|4-aminobutyrate:2-oxoglutarate transaminase activity|neurotransmitter catabolic process|identical protein binding|metal ion binding|(S)-3-amino-2-methylpropionate transaminase activity|behavioral response to cocaine|iron-sulfur cluster binding "hsa00250,hsa00280,hsa00410,hsa00640,hsa00650,hsa04727" "Alanine, aspartate and glutamate metabolism|Valine, leucine and isoleucine degradation|beta-Alanine metabolism|Propanoate metabolism|Butanoate metabolism|GABAergic synapse" ABCA1 647.8645035 682.511507 613.2174999 0.898472031 -0.154454501 0.554241153 1 2.72923608 2.411109004 19 ATP binding cassette subfamily A member 1 "GO:0005102,GO:0005319,GO:0005515,GO:0005524,GO:0005548,GO:0005768,GO:0005789,GO:0005886,GO:0005887,GO:0006869,GO:0007040,GO:0007186,GO:0007189,GO:0008203,GO:0008320,GO:0009306,GO:0010745,GO:0010875,GO:0010887,GO:0015485,GO:0016197,GO:0016887,GO:0019216,GO:0019905,GO:0023061,GO:0030139,GO:0031210,GO:0031267,GO:0032367,GO:0032489,GO:0033344,GO:0033700,GO:0034185,GO:0034186,GO:0034188,GO:0034380,GO:0034616,GO:0038027,GO:0042626,GO:0042632,GO:0043231,GO:0043691,GO:0045121,GO:0045332,GO:0045335,GO:0046623,GO:0048471,GO:0051117,GO:0055091,GO:0060155,GO:0071404,GO:0071806,GO:0090107,GO:0090108,GO:0090554,GO:0090556,GO:0097708,GO:0099039,GO:0120009,GO:0120020,GO:0140115,GO:0140328" signaling receptor binding|lipid transporter activity|protein binding|ATP binding|phospholipid transporter activity|endosome|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|lipid transport|lysosome organization|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|cholesterol metabolic process|protein transmembrane transporter activity|protein secretion|negative regulation of macrophage derived foam cell differentiation|positive regulation of cholesterol efflux|negative regulation of cholesterol storage|cholesterol binding|endosomal transport|ATPase activity|regulation of lipid metabolic process|syntaxin binding|signal release|endocytic vesicle|phosphatidylcholine binding|small GTPase binding|intracellular cholesterol transport|regulation of Cdc42 protein signal transduction|cholesterol efflux|phospholipid efflux|apolipoprotein binding|apolipoprotein A-I binding|apolipoprotein A-I receptor activity|high-density lipoprotein particle assembly|response to laminar fluid shear stress|apolipoprotein A-I-mediated signaling pathway|ATPase-coupled transmembrane transporter activity|cholesterol homeostasis|intracellular membrane-bounded organelle|reverse cholesterol transport|membrane raft|phospholipid translocation|phagocytic vesicle|sphingolipid floppase activity|perinuclear region of cytoplasm|ATPase binding|phospholipid homeostasis|platelet dense granule organization|cellular response to low-density lipoprotein particle stimulus|protein transmembrane transport|regulation of high-density lipoprotein particle assembly|positive regulation of high-density lipoprotein particle assembly|phosphatidylcholine floppase activity|phosphatidylserine floppase activity|intracellular vesicle|sphingolipid translocation|intermembrane lipid transfer|cholesterol transfer activity|export across plasma membrane|floppase activity "hsa02010,hsa04975,hsa04979" ABC transporters|Fat digestion and absorption|Cholesterol metabolism ABCA10 51.63446534 68.66731625 34.60161442 0.503902239 -0.988784228 0.095332858 1 0.579116382 0.286934862 10349 ATP binding cassette subfamily A member 10 "GO:0005319,GO:0005524,GO:0006869,GO:0016021,GO:0016887,GO:0042626,GO:0043231,GO:0055085" lipid transporter activity|ATP binding|lipid transport|integral component of membrane|ATPase activity|ATPase-coupled transmembrane transporter activity|intracellular membrane-bounded organelle|transmembrane transport hsa02010 ABC transporters ABCA12 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.017604622 0.005330456 26154 ATP binding cassette subfamily A member 12 "GO:0005102,GO:0005319,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006869,GO:0010875,GO:0016021,GO:0016887,GO:0019725,GO:0031424,GO:0032940,GO:0033700,GO:0034040,GO:0034191,GO:0035627,GO:0042626,GO:0043129,GO:0043231,GO:0045055,GO:0048286,GO:0055085,GO:0055088,GO:0061436,GO:0072659,GO:0097209,GO:0098656,GO:2000010" signaling receptor binding|lipid transporter activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|lipid transport|positive regulation of cholesterol efflux|integral component of membrane|ATPase activity|cellular homeostasis|keratinization|secretion by cell|phospholipid efflux|ATPase-coupled lipid transmembrane transporter activity|apolipoprotein A-I receptor binding|ceramide transport|ATPase-coupled transmembrane transporter activity|surfactant homeostasis|intracellular membrane-bounded organelle|regulated exocytosis|lung alveolus development|transmembrane transport|lipid homeostasis|establishment of skin barrier|protein localization to plasma membrane|epidermal lamellar body|anion transmembrane transport|positive regulation of protein localization to cell surface hsa02010 ABC transporters ABCA13 43.31115427 52.02069413 34.60161442 0.665150956 -0.588246298 0.358634114 1 0.097934557 0.064051214 154664 ATP binding cassette subfamily A member 13 "GO:0005319,GO:0005524,GO:0005886,GO:0006869,GO:0016021,GO:0030667,GO:0035577,GO:0042626,GO:0043231,GO:0043312,GO:0055085" lipid transporter activity|ATP binding|plasma membrane|lipid transport|integral component of membrane|secretory granule membrane|azurophil granule membrane|ATPase-coupled transmembrane transporter activity|intracellular membrane-bounded organelle|neutrophil degranulation|transmembrane transport hsa02010 ABC transporters ABCA2 1295.322656 1379.588808 1211.056505 0.877838742 -0.187972152 0.435635262 1 8.965674516 7.738715681 20 ATP binding cassette subfamily A member 2 "GO:0000166,GO:0001573,GO:0005319,GO:0005524,GO:0005764,GO:0005765,GO:0005768,GO:0005815,GO:0005886,GO:0006357,GO:0006629,GO:0006684,GO:0006687,GO:0006869,GO:0007626,GO:0010008,GO:0010872,GO:0016020,GO:0016021,GO:0016887,GO:0031410,GO:0032289,GO:0032383,GO:0032384,GO:0032805,GO:0042493,GO:0042626,GO:0042632,GO:0042986,GO:0043190,GO:0043231,GO:0045540,GO:0046512,GO:0048545,GO:0052548,GO:0055085,GO:0060049,GO:0061135,GO:0070723,GO:0071072,GO:0090155,GO:0090156,GO:0090370,GO:0099038,GO:0099040,GO:0150104,GO:0150110,GO:1901873,GO:1902004,GO:1902993,GO:1904375,GO:1905598,GO:1905601,GO:2000008" nucleotide binding|ganglioside metabolic process|lipid transporter activity|ATP binding|lysosome|lysosomal membrane|endosome|microtubule organizing center|plasma membrane|regulation of transcription by RNA polymerase II|lipid metabolic process|sphingomyelin metabolic process|glycosphingolipid metabolic process|lipid transport|locomotory behavior|endosome membrane|regulation of cholesterol esterification|membrane|integral component of membrane|ATPase activity|cytoplasmic vesicle|central nervous system myelin formation|regulation of intracellular cholesterol transport|negative regulation of intracellular cholesterol transport|positive regulation of low-density lipoprotein particle receptor catabolic process|response to drug|ATPase-coupled transmembrane transporter activity|cholesterol homeostasis|positive regulation of amyloid precursor protein biosynthetic process|ATP-binding cassette (ABC) transporter complex|intracellular membrane-bounded organelle|regulation of cholesterol biosynthetic process|sphingosine biosynthetic process|response to steroid hormone|regulation of endopeptidase activity|transmembrane transport|regulation of protein glycosylation|endopeptidase regulator activity|response to cholesterol|negative regulation of phospholipid biosynthetic process|negative regulation of sphingolipid biosynthetic process|cellular sphingolipid homeostasis|negative regulation of cholesterol efflux|ceramide floppase activity|ceramide translocation|transport across blood-brain barrier|negative regulation of cholesterol esterification|regulation of post-translational protein modification|positive regulation of amyloid-beta formation|positive regulation of amyloid precursor protein catabolic process|regulation of protein localization to cell periphery|negative regulation of low-density lipoprotein receptor activity|negative regulation of receptor-mediated endocytosis involved in cholesterol transport|regulation of protein localization to cell surface "hsa02010,hsa04142" ABC transporters|Lysosome ABCA3 20.85796745 17.687036 24.0288989 1.358559958 0.442078239 0.631323209 1 0.142975553 0.190990504 21 ATP binding cassette subfamily A member 3 "GO:0005319,GO:0005524,GO:0005615,GO:0005886,GO:0006855,GO:0006869,GO:0008559,GO:0010875,GO:0015914,GO:0016021,GO:0016887,GO:0030324,GO:0030659,GO:0032464,GO:0042493,GO:0042626,GO:0042908,GO:0043129,GO:0043231,GO:0044267,GO:0046470,GO:0046471,GO:0046618,GO:0046890,GO:0051384,GO:0055085,GO:0055091,GO:0070925,GO:0097208,GO:0097232,GO:0097233,GO:0120009,GO:0120019,GO:0140345,GO:0150172,GO:1902995" lipid transporter activity|ATP binding|extracellular space|plasma membrane|drug transmembrane transport|lipid transport|ATPase-coupled xenobiotic transmembrane transporter activity|positive regulation of cholesterol efflux|phospholipid transport|integral component of membrane|ATPase activity|lung development|cytoplasmic vesicle membrane|positive regulation of protein homooligomerization|response to drug|ATPase-coupled transmembrane transporter activity|xenobiotic transport|surfactant homeostasis|intracellular membrane-bounded organelle|cellular protein metabolic process|phosphatidylcholine metabolic process|phosphatidylglycerol metabolic process|drug export|regulation of lipid biosynthetic process|response to glucocorticoid|transmembrane transport|phospholipid homeostasis|organelle assembly|alveolar lamellar body|lamellar body membrane|alveolar lamellar body membrane|intermembrane lipid transfer|phosphatidylcholine transfer activity|phosphatidylcholine flippase activity|regulation of phosphatidylcholine metabolic process|positive regulation of phospholipid efflux hsa02010 ABC transporters ABCA4 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.030308393 0.013765495 24 ATP binding cassette subfamily A member 4 "GO:0001523,GO:0005215,GO:0005319,GO:0005524,GO:0005548,GO:0005783,GO:0005887,GO:0006649,GO:0006869,GO:0007601,GO:0007603,GO:0016020,GO:0016887,GO:0042626,GO:0043231,GO:0045332,GO:0045494,GO:0055085,GO:0090555,GO:0097381,GO:0140326,GO:0140327,GO:0140347" "retinoid metabolic process|transporter activity|lipid transporter activity|ATP binding|phospholipid transporter activity|endoplasmic reticulum|integral component of plasma membrane|phospholipid transfer to membrane|lipid transport|visual perception|phototransduction, visible light|membrane|ATPase activity|ATPase-coupled transmembrane transporter activity|intracellular membrane-bounded organelle|phospholipid translocation|photoreceptor cell maintenance|transmembrane transport|phosphatidylethanolamine flippase activity|photoreceptor disc membrane|ATPase-coupled intramembrane lipid transporter activity|flippase activity|N-retinylidene-phosphatidylethanolamine flippase activity" hsa02010 ABC transporters ABCA5 453.1423324 503.5603192 402.7243456 0.799753933 -0.322371913 0.249817805 1 2.842315043 2.235114502 23461 ATP binding cassette subfamily A member 5 "GO:0000139,GO:0005319,GO:0005524,GO:0005764,GO:0005765,GO:0005770,GO:0005794,GO:0006869,GO:0010745,GO:0016021,GO:0016887,GO:0031902,GO:0033344,GO:0034375,GO:0042626,GO:0043231,GO:0043691,GO:0055085" Golgi membrane|lipid transporter activity|ATP binding|lysosome|lysosomal membrane|late endosome|Golgi apparatus|lipid transport|negative regulation of macrophage derived foam cell differentiation|integral component of membrane|ATPase activity|late endosome membrane|cholesterol efflux|high-density lipoprotein particle remodeling|ATPase-coupled transmembrane transporter activity|intracellular membrane-bounded organelle|reverse cholesterol transport|transmembrane transport hsa02010 ABC transporters ABCA6 9.765044995 16.64662212 2.883467868 0.173216395 -2.529352609 0.042512867 1 0.115933659 0.019745572 23460 ATP binding cassette subfamily A member 6 "GO:0005319,GO:0005524,GO:0005654,GO:0005886,GO:0006869,GO:0016021,GO:0042626,GO:0043231,GO:0055085" lipid transporter activity|ATP binding|nucleoplasm|plasma membrane|lipid transport|integral component of membrane|ATPase-coupled transmembrane transporter activity|intracellular membrane-bounded organelle|transmembrane transport hsa02010 ABC transporters ABCA7 341.6444398 314.2049926 369.0838871 1.174659524 0.232242651 0.445795573 1 2.437642531 2.815484894 10347 ATP binding cassette subfamily A member 7 "GO:0000139,GO:0001891,GO:0005319,GO:0005524,GO:0005548,GO:0005783,GO:0005794,GO:0005886,GO:0006869,GO:0006909,GO:0007613,GO:0008542,GO:0009986,GO:0010875,GO:0016021,GO:0016887,GO:0018149,GO:0019216,GO:0030054,GO:0031901,GO:0032587,GO:0033344,GO:0033700,GO:0034188,GO:0034205,GO:0034380,GO:0034504,GO:0038027,GO:0042626,GO:0042985,GO:0043231,GO:0043409,GO:0044857,GO:0045332,GO:0045806,GO:0050766,GO:0055085,GO:0070374,GO:0090554,GO:0090556,GO:0097386,GO:0140328,GO:0150094,GO:1900223,GO:1901076,GO:1902430,GO:1902991,GO:1902995,GO:1903898,GO:2000010" Golgi membrane|phagocytic cup|lipid transporter activity|ATP binding|phospholipid transporter activity|endoplasmic reticulum|Golgi apparatus|plasma membrane|lipid transport|phagocytosis|memory|visual learning|cell surface|positive regulation of cholesterol efflux|integral component of membrane|ATPase activity|peptide cross-linking|regulation of lipid metabolic process|cell junction|early endosome membrane|ruffle membrane|cholesterol efflux|phospholipid efflux|apolipoprotein A-I receptor activity|amyloid-beta formation|high-density lipoprotein particle assembly|protein localization to nucleus|apolipoprotein A-I-mediated signaling pathway|ATPase-coupled transmembrane transporter activity|negative regulation of amyloid precursor protein biosynthetic process|intracellular membrane-bounded organelle|negative regulation of MAPK cascade|plasma membrane raft organization|phospholipid translocation|negative regulation of endocytosis|positive regulation of phagocytosis|transmembrane transport|positive regulation of ERK1 and ERK2 cascade|phosphatidylcholine floppase activity|phosphatidylserine floppase activity|glial cell projection|floppase activity|amyloid-beta clearance by cellular catabolic process|positive regulation of amyloid-beta clearance|positive regulation of engulfment of apoptotic cell|negative regulation of amyloid-beta formation|regulation of amyloid precursor protein catabolic process|positive regulation of phospholipid efflux|negative regulation of PERK-mediated unfolded protein response|positive regulation of protein localization to cell surface hsa02010 ABC transporters ABCA9 3.081612685 5.202069413 0.961155956 0.184764154 -2.436243205 0.338470402 1 0.037880322 0.006881808 10350 ATP binding cassette subfamily A member 9 "GO:0005319,GO:0005524,GO:0006869,GO:0016021,GO:0042626,GO:0043231,GO:0055085" lipid transporter activity|ATP binding|lipid transport|integral component of membrane|ATPase-coupled transmembrane transporter activity|intracellular membrane-bounded organelle|transmembrane transport hsa02010 ABC transporters ABCB1 325.8149347 340.2153396 311.4145297 0.915345352 -0.127611933 0.6842215 1 3.216415835 2.894865234 5243 ATP binding cassette subfamily B member 1 "GO:0000086,GO:0005515,GO:0005524,GO:0005654,GO:0005886,GO:0008559,GO:0009986,GO:0015562,GO:0016020,GO:0016021,GO:0016324,GO:0016887,GO:0022857,GO:0031625,GO:0042493,GO:0042626,GO:0042910,GO:0042969,GO:0042971,GO:0045332,GO:0046865,GO:0046943,GO:0047484,GO:0055085,GO:0070062,GO:0070633,GO:0072089,GO:0090554,GO:0090555,GO:0098591,GO:0099038,GO:0099040,GO:0140115,GO:0140328,GO:0150104,GO:1901529,GO:1905039,GO:1990962,GO:2001225" G2/M transition of mitotic cell cycle|protein binding|ATP binding|nucleoplasm|plasma membrane|ATPase-coupled xenobiotic transmembrane transporter activity|cell surface|efflux transmembrane transporter activity|membrane|integral component of membrane|apical plasma membrane|ATPase activity|transmembrane transporter activity|ubiquitin protein ligase binding|response to drug|ATPase-coupled transmembrane transporter activity|xenobiotic transmembrane transporter activity|lactone transport|lactone transmembrane transporter activity|phospholipid translocation|terpenoid transport|carboxylic acid transmembrane transporter activity|regulation of response to osmotic stress|transmembrane transport|extracellular exosome|transepithelial transport|stem cell proliferation|phosphatidylcholine floppase activity|phosphatidylethanolamine flippase activity|external side of apical plasma membrane|ceramide floppase activity|ceramide translocation|export across plasma membrane|floppase activity|transport across blood-brain barrier|positive regulation of anion channel activity|carboxylic acid transmembrane transport|xenobiotic transport across blood-brain barrier|regulation of chloride transport "hsa02010,hsa04976,hsa05206,hsa05226" ABC transporters|Bile secretion|MicroRNAs in cancer|Gastric cancer ABCB10 594.5901594 608.6421213 580.5381974 0.953825207 -0.068203185 0.801184 1 6.24535885 5.857298694 23456 ATP binding cassette subfamily B member 10 "GO:0005515,GO:0005524,GO:0005743,GO:0006839,GO:0016887,GO:0032592,GO:0042626,GO:0042802,GO:0055085" protein binding|ATP binding|mitochondrial inner membrane|mitochondrial transport|ATPase activity|integral component of mitochondrial membrane|ATPase-coupled transmembrane transporter activity|identical protein binding|transmembrane transport hsa02010 ABC transporters ABCB4 363.7805949 340.2153396 387.3458503 1.13853141 0.187174093 0.532773172 1 2.285582501 2.558663049 5244 ATP binding cassette subfamily B member 4 "GO:0005515,GO:0005524,GO:0005548,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0005925,GO:0006629,GO:0015629,GO:0016020,GO:0016021,GO:0016324,GO:0016887,GO:0019216,GO:0030136,GO:0032376,GO:0032782,GO:0042626,GO:0045121,GO:0045332,GO:0046581,GO:0055085,GO:0055088,GO:0061092,GO:0070062,GO:0090554,GO:0099038,GO:0099040,GO:1901557,GO:1903413,GO:2001140" protein binding|ATP binding|phospholipid transporter activity|nucleoplasm|cytoplasm|cytosol|plasma membrane|integral component of plasma membrane|focal adhesion|lipid metabolic process|actin cytoskeleton|membrane|integral component of membrane|apical plasma membrane|ATPase activity|regulation of lipid metabolic process|clathrin-coated vesicle|positive regulation of cholesterol transport|bile acid secretion|ATPase-coupled transmembrane transporter activity|membrane raft|phospholipid translocation|intercellular canaliculus|transmembrane transport|lipid homeostasis|positive regulation of phospholipid translocation|extracellular exosome|phosphatidylcholine floppase activity|ceramide floppase activity|ceramide translocation|response to fenofibrate|cellular response to bile acid|positive regulation of phospholipid transport "hsa02010,hsa04976" ABC transporters|Bile secretion ABCB6 149.6371599 156.0620824 143.2122374 0.917661967 -0.12396528 0.773538228 1 2.794881378 2.521838618 10058 ATP binding cassette subfamily B member 6 (Langereis blood group) "GO:0000139,GO:0005524,GO:0005654,GO:0005739,GO:0005740,GO:0005741,GO:0005768,GO:0005774,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0006779,GO:0006879,GO:0007420,GO:0010008,GO:0015439,GO:0015562,GO:0015886,GO:0016021,GO:0016887,GO:0020037,GO:0031307,GO:0035351,GO:0042626,GO:0043190,GO:0043588,GO:0055085,GO:0070062" Golgi membrane|ATP binding|nucleoplasm|mitochondrion|mitochondrial envelope|mitochondrial outer membrane|endosome|vacuolar membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|plasma membrane|porphyrin-containing compound biosynthetic process|cellular iron ion homeostasis|brain development|endosome membrane|ATPase-coupled heme transmembrane transporter activity|efflux transmembrane transporter activity|heme transport|integral component of membrane|ATPase activity|heme binding|integral component of mitochondrial outer membrane|heme transmembrane transport|ATPase-coupled transmembrane transporter activity|ATP-binding cassette (ABC) transporter complex|skin development|transmembrane transport|extracellular exosome hsa02010 ABC transporters ABCB7 959.3570624 886.432628 1032.281497 1.164534635 0.219753548 0.374035613 1 10.29538197 11.7887037 22 ATP binding cassette subfamily B member 7 "GO:0005515,GO:0005524,GO:0005743,GO:0006879,GO:0015232,GO:0015886,GO:0016021,GO:0016887,GO:0042626,GO:0055085" protein binding|ATP binding|mitochondrial inner membrane|cellular iron ion homeostasis|heme transmembrane transporter activity|heme transport|integral component of membrane|ATPase activity|ATPase-coupled transmembrane transporter activity|transmembrane transport hsa02010 ABC transporters ABCB8 369.9733884 376.6298255 363.3169514 0.964652629 -0.051918573 0.869410401 1 4.270244651 4.050371777 11194 ATP binding cassette subfamily B member 8 "GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005739,GO:0005743,GO:0016021,GO:0016887,GO:0031966,GO:0042626,GO:0043190,GO:0055085,GO:0062157,GO:0071805" protein binding|ATP binding|nucleoplasm|nucleolus|mitochondrion|mitochondrial inner membrane|integral component of membrane|ATPase activity|mitochondrial membrane|ATPase-coupled transmembrane transporter activity|ATP-binding cassette (ABC) transporter complex|transmembrane transport|mitochondrial ATP-gated potassium channel complex|potassium ion transmembrane transport hsa02010 ABC transporters ABCB9 224.245019 260.1034707 188.3865674 0.724275485 -0.46538955 0.181461934 1 2.077408587 1.479438399 23457 ATP binding cassette subfamily B member 9 "GO:0002474,GO:0005515,GO:0005524,GO:0005764,GO:0005765,GO:0005769,GO:0005783,GO:0015031,GO:0015433,GO:0015440,GO:0015833,GO:0016021,GO:0016887,GO:0019885,GO:0022857,GO:0030176,GO:0042288,GO:0042626,GO:0042803,GO:0042824,GO:0043231,GO:0046978,GO:0055085" antigen processing and presentation of peptide antigen via MHC class I|protein binding|ATP binding|lysosome|lysosomal membrane|early endosome|endoplasmic reticulum|protein transport|ATPase-coupled peptide antigen transmembrane transporter activity|ATPase-coupled peptide transmembrane transporter activity|peptide transport|integral component of membrane|ATPase activity|antigen processing and presentation of endogenous peptide antigen via MHC class I|transmembrane transporter activity|integral component of endoplasmic reticulum membrane|MHC class I protein binding|ATPase-coupled transmembrane transporter activity|protein homodimerization activity|MHC class I peptide loading complex|intracellular membrane-bounded organelle|TAP1 binding|transmembrane transport "hsa02010,hsa04142" ABC transporters|Lysosome ABCC1 1843.286691 2013.200863 1673.372519 0.831199981 -0.266732473 0.260378068 1 14.81942482 12.11178216 4363 ATP binding cassette subfamily C member 1 "GO:0005524,GO:0005886,GO:0005887,GO:0006691,GO:0008559,GO:0009235,GO:0009925,GO:0015420,GO:0015431,GO:0015562,GO:0015889,GO:0016020,GO:0016323,GO:0016324,GO:0016328,GO:0016887,GO:0034040,GO:0034634,GO:0034775,GO:0042493,GO:0042626,GO:0042908,GO:0042910,GO:0042969,GO:0042971,GO:0045332,GO:0046943,GO:0050729,GO:0055085,GO:0060326,GO:0070062,GO:0070633,GO:0071716,GO:0099039,GO:0140115,GO:0140359,GO:0150104,GO:1904646,GO:1905039" ATP binding|plasma membrane|integral component of plasma membrane|leukotriene metabolic process|ATPase-coupled xenobiotic transmembrane transporter activity|cobalamin metabolic process|basal plasma membrane|ATPase-coupled vitamin B12 transmembrane transporter activity|ATPase-coupled glutathione S-conjugate transmembrane transporter activity|efflux transmembrane transporter activity|cobalamin transport|membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|ATPase activity|ATPase-coupled lipid transmembrane transporter activity|glutathione transmembrane transporter activity|glutathione transmembrane transport|response to drug|ATPase-coupled transmembrane transporter activity|xenobiotic transport|xenobiotic transmembrane transporter activity|lactone transport|lactone transmembrane transporter activity|phospholipid translocation|carboxylic acid transmembrane transporter activity|positive regulation of inflammatory response|transmembrane transport|cell chemotaxis|extracellular exosome|transepithelial transport|leukotriene transport|sphingolipid translocation|export across plasma membrane|ABC-type transporter activity|transport across blood-brain barrier|cellular response to amyloid-beta|carboxylic acid transmembrane transport "hsa01523,hsa02010,hsa04071,hsa04977,hsa05206" Antifolate resistance|ABC transporters|Sphingolipid signaling pathway|Vitamin digestion and absorption|MicroRNAs in cancer ABCC10 244.107232 264.2651262 223.9493377 0.847441889 -0.238813652 0.483940061 1 2.191661863 1.826226567 89845 ATP binding cassette subfamily C member 10 "GO:0005524,GO:0005765,GO:0005886,GO:0006691,GO:0008559,GO:0015431,GO:0016020,GO:0016021,GO:0016323,GO:0016887,GO:0042626,GO:0042908,GO:0055085,GO:0071716,GO:0098656,GO:0140359" ATP binding|lysosomal membrane|plasma membrane|leukotriene metabolic process|ATPase-coupled xenobiotic transmembrane transporter activity|ATPase-coupled glutathione S-conjugate transmembrane transporter activity|membrane|integral component of membrane|basolateral plasma membrane|ATPase activity|ATPase-coupled transmembrane transporter activity|xenobiotic transport|transmembrane transport|leukotriene transport|anion transmembrane transport|ABC-type transporter activity hsa02010 ABC transporters ABCC12 67.05258959 69.70773014 64.39744905 0.923820772 -0.11431511 0.858080711 1 0.472943483 0.429603833 94160 ATP binding cassette subfamily C member 12 "GO:0005524,GO:0005783,GO:0016020,GO:0016021,GO:0016887,GO:0042626,GO:0055085" ATP binding|endoplasmic reticulum|membrane|integral component of membrane|ATPase activity|ATPase-coupled transmembrane transporter activity|transmembrane transport hsa02010 ABC transporters ABCC2 57.76309216 65.54607461 49.98010971 0.762518732 -0.391155315 0.503129833 1 0.479648092 0.35962048 1244 ATP binding cassette subfamily C member 2 "GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0006855,GO:0006954,GO:0006979,GO:0007565,GO:0008514,GO:0008559,GO:0009408,GO:0009986,GO:0010629,GO:0015127,GO:0015694,GO:0015721,GO:0015722,GO:0015723,GO:0015732,GO:0016020,GO:0016324,GO:0016887,GO:0019904,GO:0030644,GO:0031427,GO:0031526,GO:0032355,GO:0033762,GO:0035690,GO:0038183,GO:0042178,GO:0042626,GO:0042910,GO:0043627,GO:0046581,GO:0046618,GO:0046685,GO:0046691,GO:0055085,GO:0070327,GO:0070633,GO:0071222,GO:0071347,GO:0071354,GO:0071356,GO:0071549,GO:0071716,GO:0097327,GO:0120188,GO:0150104,GO:1901086,GO:1904486,GO:1990961,GO:1990962" protein binding|ATP binding|plasma membrane|integral component of plasma membrane|drug transmembrane transport|inflammatory response|response to oxidative stress|female pregnancy|organic anion transmembrane transporter activity|ATPase-coupled xenobiotic transmembrane transporter activity|response to heat|cell surface|negative regulation of gene expression|bilirubin transmembrane transporter activity|mercury ion transport|bile acid and bile salt transport|canalicular bile acid transport|bilirubin transport|prostaglandin transport|membrane|apical plasma membrane|ATPase activity|protein domain specific binding|cellular chloride ion homeostasis|response to methotrexate|brush border membrane|response to estradiol|response to glucagon|cellular response to drug|bile acid signaling pathway|xenobiotic catabolic process|ATPase-coupled transmembrane transporter activity|xenobiotic transmembrane transporter activity|response to estrogen|intercellular canaliculus|drug export|response to arsenic-containing substance|intracellular canaliculus|transmembrane transport|thyroid hormone transport|transepithelial transport|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to interleukin-6|cellular response to tumor necrosis factor|cellular response to dexamethasone stimulus|leukotriene transport|response to antineoplastic agent|regulation of bile acid secretion|transport across blood-brain barrier|benzylpenicillin metabolic process|response to 17alpha-ethynylestradiol|xenobiotic detoxification by transmembrane export across the plasma membrane|xenobiotic transport across blood-brain barrier "hsa01523,hsa01524,hsa02010,hsa04976" Antifolate resistance|Platinum drug resistance|ABC transporters|Bile secretion ABCC3 903.2911421 1180.869757 625.7125274 0.529874293 -0.916277959 0.000241299 0.065995379 10.86941162 5.663045672 8714 ATP binding cassette subfamily C member 3 "GO:0005524,GO:0005886,GO:0006855,GO:0008559,GO:0015164,GO:0015431,GO:0015432,GO:0015721,GO:0015722,GO:0015779,GO:0016020,GO:0016021,GO:0016887,GO:0042626,GO:0042908,GO:0042910,GO:0055085,GO:0071714,GO:0071716,GO:0098656,GO:0150104" ATP binding|plasma membrane|drug transmembrane transport|ATPase-coupled xenobiotic transmembrane transporter activity|glucuronoside transmembrane transporter activity|ATPase-coupled glutathione S-conjugate transmembrane transporter activity|ATPase-coupled bile acid transmembrane transporter activity|bile acid and bile salt transport|canalicular bile acid transport|glucuronoside transport|membrane|integral component of membrane|ATPase activity|ATPase-coupled transmembrane transporter activity|xenobiotic transport|xenobiotic transmembrane transporter activity|transmembrane transport|icosanoid transmembrane transporter activity|leukotriene transport|anion transmembrane transport|transport across blood-brain barrier "hsa01523,hsa02010,hsa04976" Antifolate resistance|ABC transporters|Bile secretion ABCC4 798.7704046 770.946687 826.5941222 1.072180653 0.100548007 0.692937122 1 5.216025323 5.498938163 10257 ATP binding cassette subfamily C member 4 "GO:0002576,GO:0005515,GO:0005524,GO:0005886,GO:0010243,GO:0014070,GO:0015216,GO:0015431,GO:0015562,GO:0015662,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0016404,GO:0016887,GO:0031088,GO:0032310,GO:0038183,GO:0042493,GO:0042626,GO:0042908,GO:0042910,GO:0048661,GO:0055085,GO:0055114,GO:0060271,GO:0070730,GO:0071716,GO:0098591,GO:0098656,GO:0140115,GO:0150104" "platelet degranulation|protein binding|ATP binding|plasma membrane|response to organonitrogen compound|response to organic cyclic compound|purine nucleotide transmembrane transporter activity|ATPase-coupled glutathione S-conjugate transmembrane transporter activity|efflux transmembrane transporter activity|ion transmembrane transporter activity, phosphorylative mechanism|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATPase activity|platelet dense granule membrane|prostaglandin secretion|bile acid signaling pathway|response to drug|ATPase-coupled transmembrane transporter activity|xenobiotic transport|xenobiotic transmembrane transporter activity|positive regulation of smooth muscle cell proliferation|transmembrane transport|oxidation-reduction process|cilium assembly|cAMP transport|leukotriene transport|external side of apical plasma membrane|anion transmembrane transport|export across plasma membrane|transport across blood-brain barrier" "hsa01523,hsa02010,hsa04024,hsa04976" Antifolate resistance|ABC transporters|cAMP signaling pathway|Bile secretion ABCC5 762.6371231 894.7559391 630.5183071 0.704681891 -0.504955955 0.046022333 1 4.986058262 3.454789879 10057 ATP binding cassette subfamily C member 5 "GO:0005524,GO:0005796,GO:0005886,GO:0005887,GO:0008514,GO:0010008,GO:0015216,GO:0015562,GO:0015865,GO:0016020,GO:0016323,GO:0016324,GO:0016887,GO:0030213,GO:0034634,GO:0034775,GO:0042626,GO:0042908,GO:0042910,GO:0055085,GO:0140115,GO:0150104" ATP binding|Golgi lumen|plasma membrane|integral component of plasma membrane|organic anion transmembrane transporter activity|endosome membrane|purine nucleotide transmembrane transporter activity|efflux transmembrane transporter activity|purine nucleotide transport|membrane|basolateral plasma membrane|apical plasma membrane|ATPase activity|hyaluronan biosynthetic process|glutathione transmembrane transporter activity|glutathione transmembrane transport|ATPase-coupled transmembrane transporter activity|xenobiotic transport|xenobiotic transmembrane transporter activity|transmembrane transport|export across plasma membrane|transport across blood-brain barrier "hsa01523,hsa02010" Antifolate resistance|ABC transporters ABCC6 19.25771767 13.52538047 24.99005486 1.847641543 0.88568489 0.317179342 1 0.115105198 0.209114349 368 ATP binding cassette subfamily C member 6 "GO:0005215,GO:0005524,GO:0005654,GO:0005789,GO:0005886,GO:0006855,GO:0007601,GO:0008559,GO:0015431,GO:0015867,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0016328,GO:0016887,GO:0030504,GO:0030505,GO:0042493,GO:0042626,GO:0042908,GO:0055085,GO:0071716,GO:0098656" transporter activity|ATP binding|nucleoplasm|endoplasmic reticulum membrane|plasma membrane|drug transmembrane transport|visual perception|ATPase-coupled xenobiotic transmembrane transporter activity|ATPase-coupled glutathione S-conjugate transmembrane transporter activity|ATP transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|ATPase activity|inorganic diphosphate transmembrane transporter activity|inorganic diphosphate transport|response to drug|ATPase-coupled transmembrane transporter activity|xenobiotic transport|transmembrane transport|leukotriene transport|anion transmembrane transport hsa02010 ABC transporters ABCC9 1062.729789 1064.343402 1061.116175 0.996967871 -0.004381083 0.990081767 1 6.044700562 5.925529072 10060 ATP binding cassette subfamily C member 9 "GO:0005261,GO:0005267,GO:0005524,GO:0005886,GO:0008281,GO:0008282,GO:0015272,GO:0015459,GO:0016020,GO:0016887,GO:0019829,GO:0022857,GO:0030017,GO:0031004,GO:0033198,GO:0042626,GO:0044325,GO:0051607,GO:0055085,GO:0061337,GO:0071805,GO:0098655,GO:0098662,GO:0150104,GO:1903779,GO:1990573" cation channel activity|potassium channel activity|ATP binding|plasma membrane|sulfonylurea receptor activity|inward rectifying potassium channel|ATP-activated inward rectifier potassium channel activity|potassium channel regulator activity|membrane|ATPase activity|ATPase-coupled cation transmembrane transporter activity|transmembrane transporter activity|sarcomere|potassium ion-transporting ATPase complex|response to ATP|ATPase-coupled transmembrane transporter activity|ion channel binding|defense response to virus|transmembrane transport|cardiac conduction|potassium ion transmembrane transport|cation transmembrane transport|inorganic cation transmembrane transport|transport across blood-brain barrier|regulation of cardiac conduction|potassium ion import across plasma membrane hsa02010 ABC transporters ABCD1 312.3241528 326.6899591 297.9583464 0.912052354 -0.132811454 0.675946328 1 4.75193314 4.261487989 215 ATP binding cassette subfamily D member 1 "GO:0002082,GO:0005324,GO:0005515,GO:0005524,GO:0005737,GO:0005765,GO:0005777,GO:0005778,GO:0005779,GO:0005789,GO:0005829,GO:0006635,GO:0007031,GO:0015607,GO:0015910,GO:0015916,GO:0015919,GO:0016020,GO:0016887,GO:0019899,GO:0030497,GO:0031966,GO:0031998,GO:0032000,GO:0033540,GO:0036109,GO:0036113,GO:0042626,GO:0042758,GO:0042760,GO:0042802,GO:0042803,GO:0043217,GO:0043531,GO:0043651,GO:0048471,GO:0051900,GO:0055085,GO:0055089,GO:0055092,GO:1900016,GO:1900407,GO:1903427,GO:1990535,GO:2001280" regulation of oxidative phosphorylation|long-chain fatty acid transporter activity|protein binding|ATP binding|cytoplasm|lysosomal membrane|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|endoplasmic reticulum membrane|cytosol|fatty acid beta-oxidation|peroxisome organization|ABC-type fatty-acyl-CoA transporter|long-chain fatty acid import into peroxisome|fatty-acyl-CoA transport|peroxisomal membrane transport|membrane|ATPase activity|enzyme binding|fatty acid elongation|mitochondrial membrane|regulation of fatty acid beta-oxidation|positive regulation of fatty acid beta-oxidation|fatty acid beta-oxidation using acyl-CoA oxidase|alpha-linolenic acid metabolic process|very long-chain fatty-acyl-CoA catabolic process|ATPase-coupled transmembrane transporter activity|long-chain fatty acid catabolic process|very long-chain fatty acid catabolic process|identical protein binding|protein homodimerization activity|myelin maintenance|ADP binding|linoleic acid metabolic process|perinuclear region of cytoplasm|regulation of mitochondrial depolarization|transmembrane transport|fatty acid homeostasis|sterol homeostasis|negative regulation of cytokine production involved in inflammatory response|regulation of cellular response to oxidative stress|negative regulation of reactive oxygen species biosynthetic process|neuron projection maintenance|positive regulation of unsaturated fatty acid biosynthetic process "hsa02010,hsa04146" ABC transporters|Peroxisome ABCD2 4.523346619 5.202069413 3.844623824 0.739056617 -0.436243205 0.933440272 1 0.014364613 0.010438614 225 ATP binding cassette subfamily D member 2 "GO:0000038,GO:0005324,GO:0005515,GO:0005524,GO:0005777,GO:0005778,GO:0005829,GO:0006635,GO:0007031,GO:0015910,GO:0016021,GO:0016887,GO:0032000,GO:0042626,GO:0042760,GO:0042803,GO:0043217,GO:0055085,GO:1900016,GO:1903427,GO:1990535,GO:2001280" very long-chain fatty acid metabolic process|long-chain fatty acid transporter activity|protein binding|ATP binding|peroxisome|peroxisomal membrane|cytosol|fatty acid beta-oxidation|peroxisome organization|long-chain fatty acid import into peroxisome|integral component of membrane|ATPase activity|positive regulation of fatty acid beta-oxidation|ATPase-coupled transmembrane transporter activity|very long-chain fatty acid catabolic process|protein homodimerization activity|myelin maintenance|transmembrane transport|negative regulation of cytokine production involved in inflammatory response|negative regulation of reactive oxygen species biosynthetic process|neuron projection maintenance|positive regulation of unsaturated fatty acid biosynthetic process "hsa02010,hsa04146" ABC transporters|Peroxisome ABCD3 1315.369766 1123.646993 1507.092539 1.341250898 0.423579137 0.078242104 1 13.86199141 18.28128966 5825 ATP binding cassette subfamily D member 3 "GO:0005324,GO:0005515,GO:0005524,GO:0005739,GO:0005777,GO:0005778,GO:0005782,GO:0005829,GO:0006633,GO:0006635,GO:0007031,GO:0014070,GO:0015910,GO:0016020,GO:0016021,GO:0016887,GO:0042493,GO:0042626,GO:0042760,GO:0042803,GO:0043231,GO:0043621,GO:0055085" long-chain fatty acid transporter activity|protein binding|ATP binding|mitochondrion|peroxisome|peroxisomal membrane|peroxisomal matrix|cytosol|fatty acid biosynthetic process|fatty acid beta-oxidation|peroxisome organization|response to organic cyclic compound|long-chain fatty acid import into peroxisome|membrane|integral component of membrane|ATPase activity|response to drug|ATPase-coupled transmembrane transporter activity|very long-chain fatty acid catabolic process|protein homodimerization activity|intracellular membrane-bounded organelle|protein self-association|transmembrane transport "hsa02010,hsa04146" ABC transporters|Peroxisome ABCD4 801.9356912 866.6647642 737.2066182 0.850624888 -0.233405028 0.354251103 1 14.40433062 12.04765008 5826 ATP binding cassette subfamily D member 4 "GO:0005324,GO:0005515,GO:0005524,GO:0005765,GO:0005777,GO:0005778,GO:0005789,GO:0006635,GO:0007031,GO:0009235,GO:0015910,GO:0016021,GO:0016887,GO:0042626,GO:0042760,GO:0043190,GO:0055085,GO:1990830" long-chain fatty acid transporter activity|protein binding|ATP binding|lysosomal membrane|peroxisome|peroxisomal membrane|endoplasmic reticulum membrane|fatty acid beta-oxidation|peroxisome organization|cobalamin metabolic process|long-chain fatty acid import into peroxisome|integral component of membrane|ATPase activity|ATPase-coupled transmembrane transporter activity|very long-chain fatty acid catabolic process|ATP-binding cassette (ABC) transporter complex|transmembrane transport|cellular response to leukemia inhibitory factor "hsa02010,hsa04146" ABC transporters|Peroxisome ABCE1 3233.214627 3264.818764 3201.610489 0.980639576 -0.028205108 0.906540217 1 44.82566939 43.22225077 6059 ATP binding cassette subfamily E member 1 "GO:0000054,GO:0005506,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005852,GO:0006413,GO:0006415,GO:0016020,GO:0016032,GO:0016887,GO:0043024,GO:0051607,GO:0060338,GO:0060698,GO:0060702" ribosomal subunit export from nucleus|iron ion binding|protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|translational termination|membrane|viral process|ATPase activity|ribosomal small subunit binding|defense response to virus|regulation of type I interferon-mediated signaling pathway|endoribonuclease inhibitor activity|negative regulation of endoribonuclease activity ABCF1 1295.788143 1417.043708 1174.532578 0.828861221 -0.270797528 0.260718021 1 22.20999069 18.10095032 23 ATP binding cassette subfamily F member 1 "GO:0003723,GO:0005515,GO:0005524,GO:0005635,GO:0005654,GO:0005829,GO:0006412,GO:0006954,GO:0008135,GO:0016020,GO:0016887,GO:0055085" "RNA binding|protein binding|ATP binding|nuclear envelope|nucleoplasm|cytosol|translation|inflammatory response|translation factor activity, RNA binding|membrane|ATPase activity|transmembrane transport" ABCF2 203.0008228 207.0423626 198.9592829 0.960959295 -0.057452773 0.887225432 1 2.440793101 2.306254005 10061 ATP binding cassette subfamily F member 2 "GO:0005524,GO:0016020,GO:0016887" ATP binding|membrane|ATPase activity hsa05130 Pathogenic Escherichia coli infection ABCF3 757.5199564 773.0275148 742.012398 0.959878379 -0.059076473 0.820248805 1 16.45594643 15.53138742 55324 ATP binding cassette subfamily F member 3 "GO:0005515,GO:0005524,GO:0016020,GO:0016887,GO:0045296,GO:0051607" protein binding|ATP binding|membrane|ATPase activity|cadherin binding|defense response to virus ABCG1 2.561405743 4.161655531 0.961155956 0.230955193 -2.11431511 0.482263142 1 0.019368615 0.004398428 9619 ATP binding cassette subfamily G member 1 "GO:0000139,GO:0005515,GO:0005524,GO:0005543,GO:0005739,GO:0005768,GO:0005789,GO:0005794,GO:0005886,GO:0008203,GO:0009897,GO:0010033,GO:0010745,GO:0010872,GO:0010887,GO:0015485,GO:0016021,GO:0016887,GO:0019534,GO:0032367,GO:0033344,GO:0033700,GO:0033993,GO:0034041,GO:0034204,GO:0034374,GO:0034375,GO:0034436,GO:0042632,GO:0042803,GO:0042987,GO:0043531,GO:0043691,GO:0045542,GO:0046982,GO:0050714,GO:0055037,GO:0055085,GO:0055091,GO:0090554,GO:0120009,GO:0120020,GO:0140328,GO:1901998,GO:1902004" Golgi membrane|protein binding|ATP binding|phospholipid binding|mitochondrion|endosome|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|cholesterol metabolic process|external side of plasma membrane|response to organic substance|negative regulation of macrophage derived foam cell differentiation|regulation of cholesterol esterification|negative regulation of cholesterol storage|cholesterol binding|integral component of membrane|ATPase activity|toxin transmembrane transporter activity|intracellular cholesterol transport|cholesterol efflux|phospholipid efflux|response to lipid|ATPase-coupled sterol transmembrane transporter activity|lipid translocation|low-density lipoprotein particle remodeling|high-density lipoprotein particle remodeling|glycoprotein transport|cholesterol homeostasis|protein homodimerization activity|amyloid precursor protein catabolic process|ADP binding|reverse cholesterol transport|positive regulation of cholesterol biosynthetic process|protein heterodimerization activity|positive regulation of protein secretion|recycling endosome|transmembrane transport|phospholipid homeostasis|phosphatidylcholine floppase activity|intermembrane lipid transfer|cholesterol transfer activity|floppase activity|toxin transport|positive regulation of amyloid-beta formation hsa02010 ABC transporters ABCG2 342.1992453 328.7707869 355.6277037 1.081688878 0.113285602 0.715035268 1 3.309921268 3.520393468 9429 ATP binding cassette subfamily G member 2 (Junior blood group) "GO:0005515,GO:0005524,GO:0005654,GO:0005886,GO:0006879,GO:0008514,GO:0008559,GO:0015143,GO:0015225,GO:0015562,GO:0015711,GO:0015747,GO:0015878,GO:0016021,GO:0016324,GO:0031526,GO:0031966,GO:0032217,GO:0032218,GO:0042626,GO:0042802,GO:0042803,GO:0042910,GO:0045121,GO:0046415,GO:0055085,GO:0070633,GO:0097744,GO:0098591,GO:0140115,GO:0150104,GO:1990748,GO:1990962" protein binding|ATP binding|nucleoplasm|plasma membrane|cellular iron ion homeostasis|organic anion transmembrane transporter activity|ATPase-coupled xenobiotic transmembrane transporter activity|urate transmembrane transporter activity|biotin transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transport|urate transport|biotin transport|integral component of membrane|apical plasma membrane|brush border membrane|mitochondrial membrane|riboflavin transmembrane transporter activity|riboflavin transport|ATPase-coupled transmembrane transporter activity|identical protein binding|protein homodimerization activity|xenobiotic transmembrane transporter activity|membrane raft|urate metabolic process|transmembrane transport|transepithelial transport|urate salt excretion|external side of apical plasma membrane|export across plasma membrane|transport across blood-brain barrier|cellular detoxification|xenobiotic transport across blood-brain barrier "hsa01523,hsa02010,hsa04976" Antifolate resistance|ABC transporters|Bile secretion ABCG4 36.94978409 36.41448589 37.48508228 1.029400289 0.041804092 0.99682426 1 0.43759833 0.442925945 64137 ATP binding cassette subfamily G member 4 "GO:0005515,GO:0005524,GO:0005886,GO:0016021,GO:0016887,GO:0033344,GO:0042626,GO:0042802,GO:0042803,GO:0046982,GO:0055085,GO:1990830" protein binding|ATP binding|plasma membrane|integral component of membrane|ATPase activity|cholesterol efflux|ATPase-coupled transmembrane transporter activity|identical protein binding|protein homodimerization activity|protein heterodimerization activity|transmembrane transport|cellular response to leukemia inhibitory factor hsa02010 ABC transporters ABHD10 980.4628644 885.3922141 1075.533515 1.214753753 0.280663889 0.25473514 1 17.64441941 21.07496201 55347 "abhydrolase domain containing 10, depalmitoylase" "GO:0002084,GO:0004553,GO:0005739,GO:0005759,GO:0005829,GO:0008474,GO:0018215,GO:0019391,GO:0052695,GO:0102390" "protein depalmitoylation|hydrolase activity, hydrolyzing O-glycosyl compounds|mitochondrion|mitochondrial matrix|cytosol|palmitoyl-(protein) hydrolase activity|protein phosphopantetheinylation|glucuronoside catabolic process|cellular glucuronidation|mycophenolic acid acyl-glucuronide esterase activity" ABHD11 416.4108148 422.4080364 410.4135932 0.971604605 -0.041558767 0.892910237 1 14.35868825 13.71751707 83451 abhydrolase domain containing 11 "GO:0003674,GO:0005575,GO:0005739,GO:0008150,GO:0016787" molecular_function|cellular_component|mitochondrion|biological_process|hydrolase activity ABHD12 1458.471949 1297.396112 1619.547786 1.248306336 0.319972016 0.180679104 1 22.40040309 27.49464944 26090 "abhydrolase domain containing 12, lysophospholipase" "GO:0002084,GO:0004620,GO:0004622,GO:0005789,GO:0005886,GO:0006660,GO:0007628,GO:0008474,GO:0009395,GO:0010996,GO:0016020,GO:0016021,GO:0018215,GO:0032281,GO:0032839,GO:0046464,GO:0046475,GO:0047372,GO:0050727,GO:0052651" protein depalmitoylation|phospholipase activity|lysophospholipase activity|endoplasmic reticulum membrane|plasma membrane|phosphatidylserine catabolic process|adult walking behavior|palmitoyl-(protein) hydrolase activity|phospholipid catabolic process|response to auditory stimulus|membrane|integral component of membrane|protein phosphopantetheinylation|AMPA glutamate receptor complex|dendrite cytoplasm|acylglycerol catabolic process|glycerophospholipid catabolic process|acylglycerol lipase activity|regulation of inflammatory response|monoacylglycerol catabolic process ABHD13 646.8838402 631.5312268 662.2364537 1.048620283 0.068492357 0.796906487 1 5.021403586 5.177433873 84945 abhydrolase domain containing 13 "GO:0002084,GO:0008474,GO:0016020,GO:0016021,GO:0018215,GO:0032839" protein depalmitoylation|palmitoyl-(protein) hydrolase activity|membrane|integral component of membrane|protein phosphopantetheinylation|dendrite cytoplasm ABHD14A 53.9580973 66.58648849 41.32970611 0.620692081 -0.688050355 0.239874344 1 3.333582092 2.034503951 25864 abhydrolase domain containing 14A "GO:0005737,GO:0016021,GO:0016787" cytoplasm|integral component of membrane|hydrolase activity ABHD14B 1174.347183 1155.899824 1192.794541 1.031918612 0.045329189 0.855022749 1 33.2372032 33.72415652 84836 abhydrolase domain containing 14B "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0016787,GO:0045944,GO:0050427,GO:0070062" protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|hydrolase activity|positive regulation of transcription by RNA polymerase II|3'-phosphoadenosine 5'-phosphosulfate metabolic process|extracellular exosome ABHD15 303.8618331 356.8619617 250.8617045 0.70296566 -0.50847388 0.104396634 1 5.453913807 3.769758759 116236 abhydrolase domain containing 15 "GO:0005515,GO:0005576,GO:0016020,GO:0034338,GO:0044255,GO:0047372" protein binding|extracellular region|membrane|short-chain carboxylesterase activity|cellular lipid metabolic process|acylglycerol lipase activity ABHD16A 233.7773207 258.0226429 209.5319984 0.812068259 -0.300327096 0.383958804 1 5.925212662 4.73116023 7920 "abhydrolase domain containing 16A, phospholipase" "GO:0004620,GO:0004622,GO:0005515,GO:0006660,GO:0008474,GO:0016020,GO:0016021,GO:0018215,GO:0047372,GO:0052651,GO:0098734,GO:1905344" phospholipase activity|lysophospholipase activity|protein binding|phosphatidylserine catabolic process|palmitoyl-(protein) hydrolase activity|membrane|integral component of membrane|protein phosphopantetheinylation|acylglycerol lipase activity|monoacylglycerol catabolic process|macromolecule depalmitoylation|prostaglandin catabolic process ABHD17A 790.2193806 723.0876484 857.3511127 1.18568076 0.245715622 0.330344047 1 7.175503685 8.365489205 81926 "abhydrolase domain containing 17A, depalmitoylase" "GO:0002084,GO:0005515,GO:0005886,GO:0008474,GO:0010008,GO:0016020,GO:0016607,GO:0018215,GO:0043197,GO:0043231,GO:0055038,GO:0072657,GO:0098978,GO:0099031,GO:0099033,GO:0099175,GO:1902817,GO:1905668" protein depalmitoylation|protein binding|plasma membrane|palmitoyl-(protein) hydrolase activity|endosome membrane|membrane|nuclear speck|protein phosphopantetheinylation|dendritic spine|intracellular membrane-bounded organelle|recycling endosome membrane|protein localization to membrane|glutamatergic synapse|anchored component of postsynaptic density membrane|anchored component of postsynaptic recycling endosome membrane|regulation of postsynapse organization|negative regulation of protein localization to microtubule|positive regulation of protein localization to endosome ABHD17B 365.8909908 370.3873422 361.3946395 0.975720815 -0.035459689 0.914331143 1 4.717635253 4.526068355 51104 "abhydrolase domain containing 17B, depalmitoylase" "GO:0002084,GO:0005886,GO:0008474,GO:0010008,GO:0016020,GO:0018215,GO:0043197,GO:0055038,GO:0098978,GO:0099031,GO:0099033,GO:0099175,GO:1902473,GO:1902817,GO:1902950,GO:1905668" protein depalmitoylation|plasma membrane|palmitoyl-(protein) hydrolase activity|endosome membrane|membrane|protein phosphopantetheinylation|dendritic spine|recycling endosome membrane|glutamatergic synapse|anchored component of postsynaptic density membrane|anchored component of postsynaptic recycling endosome membrane|regulation of postsynapse organization|regulation of protein localization to synapse|negative regulation of protein localization to microtubule|regulation of dendritic spine maintenance|positive regulation of protein localization to endosome ABHD17C 229.694923 251.7801596 207.6096865 0.8245673 -0.278290845 0.423553736 1 5.69125132 4.614291754 58489 "abhydrolase domain containing 17C, depalmitoylase" "GO:0002084,GO:0005515,GO:0005886,GO:0008474,GO:0010008,GO:0018215,GO:0043197,GO:0055038,GO:0098839,GO:0098978,GO:0099175,GO:1902817,GO:1905668" protein depalmitoylation|protein binding|plasma membrane|palmitoyl-(protein) hydrolase activity|endosome membrane|protein phosphopantetheinylation|dendritic spine|recycling endosome membrane|postsynaptic density membrane|glutamatergic synapse|regulation of postsynapse organization|negative regulation of protein localization to microtubule|positive regulation of protein localization to endosome ABHD18 225.3401531 225.7698125 224.9104937 0.996193828 -0.005501623 1 1 4.555357258 4.462081184 80167 abhydrolase domain containing 18 GO:0005576 extracellular region ABHD2 1500.918869 1705.238354 1296.599385 0.760362551 -0.395240616 0.097657946 1 20.08950041 15.01969226 11057 "abhydrolase domain containing 2, acylglycerol lipase" "GO:0001669,GO:0003707,GO:0007340,GO:0008126,GO:0009611,GO:0016021,GO:0030336,GO:0032570,GO:0033878,GO:0034338,GO:0036126,GO:0042562,GO:0043401,GO:0044255,GO:0046464,GO:0047372,GO:0048240,GO:0051792,GO:0051793,GO:0097524" acrosomal vesicle|steroid hormone receptor activity|acrosome reaction|acetylesterase activity|response to wounding|integral component of membrane|negative regulation of cell migration|response to progesterone|hormone-sensitive lipase activity|short-chain carboxylesterase activity|sperm flagellum|hormone binding|steroid hormone mediated signaling pathway|cellular lipid metabolic process|acylglycerol catabolic process|acylglycerol lipase activity|sperm capacitation|medium-chain fatty acid biosynthetic process|medium-chain fatty acid catabolic process|sperm plasma membrane ABHD3 333.2563477 358.9427895 307.5699059 0.856877238 -0.222839567 0.467905476 1 6.426070771 5.414212397 171586 "abhydrolase domain containing 3, phospholipase" "GO:0004623,GO:0005575,GO:0005886,GO:0006656,GO:0008126,GO:0008970,GO:0016021,GO:0034338,GO:0044255,GO:0046470,GO:0047372,GO:0051792,GO:0051793,GO:0052739,GO:0052740,GO:0102567,GO:0102568" "phospholipase A2 activity|cellular_component|plasma membrane|phosphatidylcholine biosynthetic process|acetylesterase activity|phospholipase A1 activity|integral component of membrane|short-chain carboxylesterase activity|cellular lipid metabolic process|phosphatidylcholine metabolic process|acylglycerol lipase activity|medium-chain fatty acid biosynthetic process|medium-chain fatty acid catabolic process|phosphatidylserine 1-acylhydrolase activity|1-acyl-2-lysophosphatidylserine acylhydrolase activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)" ABHD4 874.7445414 1062.262574 687.2265085 0.646945986 -0.628282829 0.011729463 0.643952702 18.58112135 11.81982702 63874 "abhydrolase domain containing 4, N-acyl phospholipase B" "GO:0004622,GO:0005515,GO:0005739,GO:0005789,GO:0005811,GO:0006654,GO:0016042,GO:0016787,GO:0036152,GO:0042171,GO:0052689,GO:0055088,GO:0070292" lysophospholipase activity|protein binding|mitochondrion|endoplasmic reticulum membrane|lipid droplet|phosphatidic acid biosynthetic process|lipid catabolic process|hydrolase activity|phosphatidylethanolamine acyl-chain remodeling|lysophosphatidic acid acyltransferase activity|carboxylic ester hydrolase activity|lipid homeostasis|N-acylphosphatidylethanolamine metabolic process ABHD5 707.7285451 702.2793708 713.1777193 1.015518537 0.022216575 0.936689347 1 6.14415726 6.135095917 51099 "abhydrolase domain containing 5, lysophosphatidic acid acyltransferase" "GO:0003841,GO:0004806,GO:0005515,GO:0005654,GO:0005739,GO:0005811,GO:0005829,GO:0006631,GO:0006654,GO:0010891,GO:0010898,GO:0030154,GO:0042171,GO:0043231,GO:0051006,GO:0052689,GO:0055088" 1-acylglycerol-3-phosphate O-acyltransferase activity|triglyceride lipase activity|protein binding|nucleoplasm|mitochondrion|lipid droplet|cytosol|fatty acid metabolic process|phosphatidic acid biosynthetic process|negative regulation of sequestering of triglyceride|positive regulation of triglyceride catabolic process|cell differentiation|lysophosphatidic acid acyltransferase activity|intracellular membrane-bounded organelle|positive regulation of lipoprotein lipase activity|carboxylic ester hydrolase activity|lipid homeostasis hsa04923 Regulation of lipolysis in adipocytes ABHD6 209.0105627 200.7998793 217.2212461 1.081779764 0.113406815 0.761916544 1 4.350921846 4.6279783 57406 "abhydrolase domain containing 6, acylglycerol lipase" "GO:0004620,GO:0005515,GO:0005739,GO:0005765,GO:0005886,GO:0009395,GO:0016021,GO:0030336,GO:0031902,GO:0031966,GO:0032281,GO:0046464,GO:0046889,GO:0047372,GO:0052651,GO:0060292,GO:0098978,GO:0098982,GO:0099055,GO:0120163,GO:2000124,GO:2001311" phospholipase activity|protein binding|mitochondrion|lysosomal membrane|plasma membrane|phospholipid catabolic process|integral component of membrane|negative regulation of cell migration|late endosome membrane|mitochondrial membrane|AMPA glutamate receptor complex|acylglycerol catabolic process|positive regulation of lipid biosynthetic process|acylglycerol lipase activity|monoacylglycerol catabolic process|long-term synaptic depression|glutamatergic synapse|GABA-ergic synapse|integral component of postsynaptic membrane|negative regulation of cold-induced thermogenesis|regulation of endocannabinoid signaling pathway|lysobisphosphatidic acid metabolic process hsa04723 Retrograde endocannabinoid signaling ABHD8 354.7634698 355.8215479 353.7053918 0.99405276 -0.008605669 0.987743979 1 9.299481899 9.08948689 79575 abhydrolase domain containing 8 "GO:0005515,GO:0005739,GO:0006654,GO:0042171,GO:0052689,GO:0055088,GO:0070062" protein binding|mitochondrion|phosphatidic acid biosynthetic process|lysophosphatidic acid acyltransferase activity|carboxylic ester hydrolase activity|lipid homeostasis|extracellular exosome ABI1 1412.082369 1530.448821 1293.715917 0.845317987 -0.242433947 0.311446679 1 16.62810276 13.82082565 10006 abl interactor 1 "GO:0005515,GO:0005622,GO:0005634,GO:0005783,GO:0005829,GO:0005856,GO:0007169,GO:0008092,GO:0008154,GO:0008285,GO:0014069,GO:0016032,GO:0017124,GO:0018108,GO:0030027,GO:0030296,GO:0030426,GO:0031209,GO:0032433,GO:0035591,GO:0038096,GO:0045296,GO:0048010,GO:0061098,GO:0070062" protein binding|intracellular anatomical structure|nucleus|endoplasmic reticulum|cytosol|cytoskeleton|transmembrane receptor protein tyrosine kinase signaling pathway|cytoskeletal protein binding|actin polymerization or depolymerization|negative regulation of cell population proliferation|postsynaptic density|viral process|SH3 domain binding|peptidyl-tyrosine phosphorylation|lamellipodium|protein tyrosine kinase activator activity|growth cone|SCAR complex|filopodium tip|signaling adaptor activity|Fc-gamma receptor signaling pathway involved in phagocytosis|cadherin binding|vascular endothelial growth factor receptor signaling pathway|positive regulation of protein tyrosine kinase activity|extracellular exosome "hsa05130,hsa05132" Pathogenic Escherichia coli infection|Salmonella infection ABI2 4261.236432 3897.390404 4625.08246 1.186712641 0.246970633 0.300728413 1 26.43576039 30.84668894 10152 abl interactor 2 "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005912,GO:0007010,GO:0007399,GO:0008093,GO:0008154,GO:0010592,GO:0016032,GO:0016477,GO:0016601,GO:0017124,GO:0018108,GO:0019900,GO:0030027,GO:0031209,GO:0031267,GO:0031625,GO:0032433,GO:0035591,GO:0042802,GO:0043197,GO:0061001,GO:0070064,GO:0070309,GO:2000601" protein binding|nucleus|cytoplasm|cytosol|cytoskeleton|adherens junction|cytoskeleton organization|nervous system development|cytoskeletal anchor activity|actin polymerization or depolymerization|positive regulation of lamellipodium assembly|viral process|cell migration|Rac protein signal transduction|SH3 domain binding|peptidyl-tyrosine phosphorylation|kinase binding|lamellipodium|SCAR complex|small GTPase binding|ubiquitin protein ligase binding|filopodium tip|signaling adaptor activity|identical protein binding|dendritic spine|regulation of dendritic spine morphogenesis|proline-rich region binding|lens fiber cell morphogenesis|positive regulation of Arp2/3 complex-mediated actin nucleation hsa04810 Regulation of actin cytoskeleton ABI3BP 131.3701663 168.547049 94.19328369 0.558854541 -0.839455269 0.048473434 1 1.213251447 0.666685149 25890 ABI family member 3 binding protein "GO:0005201,GO:0005576,GO:0005615,GO:0062023" extracellular matrix structural constituent|extracellular region|extracellular space|collagen-containing extracellular matrix ABITRAM 444.1899883 457.7821084 430.5978683 0.940617513 -0.088319901 0.759927428 1 11.40036853 10.54394495 54942 actin binding transcription modulator "GO:0003785,GO:0005515,GO:0005634,GO:0016607,GO:0030027,GO:0030425,GO:0030426,GO:0030833,GO:0032433,GO:0048813,GO:0051015,GO:0051489" actin monomer binding|protein binding|nucleus|nuclear speck|lamellipodium|dendrite|growth cone|regulation of actin filament polymerization|filopodium tip|dendrite morphogenesis|actin filament binding|regulation of filopodium assembly ABL1 3145.273887 3252.333797 3038.213977 0.934164254 -0.098251853 0.67904441 1 24.82778962 22.80512622 25 "ABL proto-oncogene 1, non-receptor tyrosine kinase" "GO:0000278,GO:0000287,GO:0000400,GO:0000405,GO:0001784,GO:0001843,GO:0001922,GO:0001934,GO:0002322,GO:0002333,GO:0003677,GO:0003713,GO:0003785,GO:0004515,GO:0004672,GO:0004713,GO:0004715,GO:0005080,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0006298,GO:0006355,GO:0006464,GO:0006468,GO:0006897,GO:0006914,GO:0006974,GO:0006975,GO:0006979,GO:0007050,GO:0007173,GO:0007204,GO:0007229,GO:0008022,GO:0008630,GO:0009791,GO:0010506,GO:0010595,GO:0015629,GO:0016301,GO:0016604,GO:0017124,GO:0018108,GO:0019905,GO:0021587,GO:0022408,GO:0030035,GO:0030036,GO:0030100,GO:0030145,GO:0030155,GO:0030425,GO:0030514,GO:0030516,GO:0031113,GO:0031252,GO:0031965,GO:0032489,GO:0032729,GO:0032743,GO:0032956,GO:0032991,GO:0033690,GO:0034446,GO:0034599,GO:0035791,GO:0038083,GO:0038096,GO:0038189,GO:0038191,GO:0042169,GO:0042770,GO:0042981,GO:0043025,GO:0043065,GO:0043123,GO:0043124,GO:0043542,GO:0045184,GO:0045580,GO:0045930,GO:0045931,GO:0045944,GO:0046632,GO:0046777,GO:0046875,GO:0048471,GO:0048536,GO:0048538,GO:0048668,GO:0050731,GO:0050798,GO:0050852,GO:0050853,GO:0050885,GO:0051015,GO:0051019,GO:0051149,GO:0051281,GO:0051353,GO:0051444,GO:0051496,GO:0051882,GO:0051894,GO:0060020,GO:0060563,GO:0070064,GO:0070301,GO:0070373,GO:0070374,GO:0071103,GO:0071222,GO:0071901,GO:0072359,GO:0090050,GO:0090135,GO:0097100,GO:0098794,GO:1900026,GO:1900272,GO:1900275,GO:1901216,GO:1902036,GO:1903053,GO:1903351,GO:1904528,GO:1904531,GO:1905244,GO:1905555,GO:1990051,GO:1990837,GO:2000096,GO:2000145,GO:2000249,GO:2000251,GO:2000352,GO:2000773,GO:2001020" "mitotic cell cycle|magnesium ion binding|four-way junction DNA binding|bubble DNA binding|phosphotyrosine residue binding|neural tube closure|B-1 B cell homeostasis|positive regulation of protein phosphorylation|B cell proliferation involved in immune response|transitional one stage B cell differentiation|DNA binding|transcription coactivator activity|actin monomer binding|nicotinate-nucleotide adenylyltransferase activity|protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein kinase C binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|cytosol|mismatch repair|regulation of transcription, DNA-templated|cellular protein modification process|protein phosphorylation|endocytosis|autophagy|cellular response to DNA damage stimulus|DNA damage induced protein phosphorylation|response to oxidative stress|cell cycle arrest|epidermal growth factor receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|integrin-mediated signaling pathway|protein C-terminus binding|intrinsic apoptotic signaling pathway in response to DNA damage|post-embryonic development|regulation of autophagy|positive regulation of endothelial cell migration|actin cytoskeleton|kinase activity|nuclear body|SH3 domain binding|peptidyl-tyrosine phosphorylation|syntaxin binding|cerebellum morphogenesis|negative regulation of cell-cell adhesion|microspike assembly|actin cytoskeleton organization|regulation of endocytosis|manganese ion binding|regulation of cell adhesion|dendrite|negative regulation of BMP signaling pathway|regulation of axon extension|regulation of microtubule polymerization|cell leading edge|nuclear membrane|regulation of Cdc42 protein signal transduction|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|regulation of actin cytoskeleton organization|protein-containing complex|positive regulation of osteoblast proliferation|substrate adhesion-dependent cell spreading|cellular response to oxidative stress|platelet-derived growth factor receptor-beta signaling pathway|peptidyl-tyrosine autophosphorylation|Fc-gamma receptor signaling pathway involved in phagocytosis|neuropilin signaling pathway|neuropilin binding|SH2 domain binding|signal transduction in response to DNA damage|regulation of apoptotic process|neuronal cell body|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|endothelial cell migration|establishment of protein localization|regulation of T cell differentiation|negative regulation of mitotic cell cycle|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|alpha-beta T cell differentiation|protein autophosphorylation|ephrin receptor binding|perinuclear region of cytoplasm|spleen development|thymus development|collateral sprouting|positive regulation of peptidyl-tyrosine phosphorylation|activated T cell proliferation|T cell receptor signaling pathway|B cell receptor signaling pathway|neuromuscular process controlling balance|actin filament binding|mitogen-activated protein kinase binding|positive regulation of muscle cell differentiation|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of oxidoreductase activity|negative regulation of ubiquitin-protein transferase activity|positive regulation of stress fiber assembly|mitochondrial depolarization|positive regulation of focal adhesion assembly|Bergmann glial cell differentiation|neuroepithelial cell differentiation|proline-rich region binding|cellular response to hydrogen peroxide|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|DNA conformation change|cellular response to lipopolysaccharide|negative regulation of protein serine/threonine kinase activity|circulatory system development|positive regulation of cell migration involved in sprouting angiogenesis|actin filament branching|supercoiled DNA binding|postsynapse|positive regulation of substrate adhesion-dependent cell spreading|negative regulation of long-term synaptic potentiation|negative regulation of phospholipase C activity|positive regulation of neuron death|regulation of hematopoietic stem cell differentiation|regulation of extracellular matrix organization|cellular response to dopamine|positive regulation of microtubule binding|positive regulation of actin filament binding|regulation of modification of synaptic structure|positive regulation of blood vessel branching|activation of protein kinase C activity|sequence-specific double-stranded DNA binding|positive regulation of Wnt signaling pathway, planar cell polarity pathway|regulation of cell motility|regulation of actin cytoskeleton reorganization|positive regulation of actin cytoskeleton reorganization|negative regulation of endothelial cell apoptotic process|negative regulation of cellular senescence|regulation of response to DNA damage stimulus" "hsa04012,hsa04014,hsa04110,hsa04360,hsa04722,hsa05130,hsa05200,hsa05206,hsa05220,hsa05416" ErbB signaling pathway|Ras signaling pathway|Cell cycle|Axon guidance|Neurotrophin signaling pathway|Pathogenic Escherichia coli infection|Pathways in cancer|MicroRNAs in cancer|Chronic myeloid leukemia|Viral myocarditis ABL2 2802.754423 2624.964226 2980.54462 1.135461044 0.18327821 0.438771359 1 9.072567596 10.12916463 27 "ABL proto-oncogene 2, non-receptor tyrosine kinase" "GO:0000287,GO:0001784,GO:0003785,GO:0004672,GO:0004713,GO:0004715,GO:0005515,GO:0005524,GO:0005829,GO:0006464,GO:0007155,GO:0007165,GO:0007204,GO:0010506,GO:0010863,GO:0010976,GO:0015629,GO:0018108,GO:0030100,GO:0030145,GO:0030155,GO:0035024,GO:0035640,GO:0051015,GO:0051353,GO:0071300,GO:2000145,GO:2000249" magnesium ion binding|phosphotyrosine residue binding|actin monomer binding|protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|cytosol|cellular protein modification process|cell adhesion|signal transduction|positive regulation of cytosolic calcium ion concentration|regulation of autophagy|positive regulation of phospholipase C activity|positive regulation of neuron projection development|actin cytoskeleton|peptidyl-tyrosine phosphorylation|regulation of endocytosis|manganese ion binding|regulation of cell adhesion|negative regulation of Rho protein signal transduction|exploration behavior|actin filament binding|positive regulation of oxidoreductase activity|cellular response to retinoic acid|regulation of cell motility|regulation of actin cytoskeleton reorganization "hsa04012,hsa04014,hsa05416" ErbB signaling pathway|Ras signaling pathway|Viral myocarditis ABLIM1 80.33516587 103.0009744 57.66935736 0.559891377 -0.836781134 0.09766388 1 0.472045745 0.259871734 3983 actin binding LIM protein 1 "GO:0001725,GO:0003779,GO:0005515,GO:0005737,GO:0007010,GO:0007601,GO:0009887,GO:0015629,GO:0030027,GO:0030032,GO:0046872,GO:0051015,GO:0060271" stress fiber|actin binding|protein binding|cytoplasm|cytoskeleton organization|visual perception|animal organ morphogenesis|actin cytoskeleton|lamellipodium|lamellipodium assembly|metal ion binding|actin filament binding|cilium assembly hsa04360 Axon guidance ABLIM3 2166.550281 2324.284614 2008.815948 0.86427279 -0.210441353 0.373653467 1 19.88821517 16.9012112 22885 actin binding LIM protein family member 3 "GO:0001725,GO:0005515,GO:0005737,GO:0006351,GO:0015629,GO:0030027,GO:0030032,GO:0030036,GO:0045944,GO:0046872,GO:0051015,GO:0060271,GO:0098978,GO:1903955" "stress fiber|protein binding|cytoplasm|transcription, DNA-templated|actin cytoskeleton|lamellipodium|lamellipodium assembly|actin cytoskeleton organization|positive regulation of transcription by RNA polymerase II|metal ion binding|actin filament binding|cilium assembly|glutamatergic synapse|positive regulation of protein targeting to mitochondrion" hsa04360 Axon guidance ABR 2636.052386 2777.905067 2494.199706 0.89787075 -0.155420313 0.511420775 1 11.96253432 10.56107676 29 ABR activator of RhoGEF and GTPase "GO:0005085,GO:0005096,GO:0005515,GO:0005829,GO:0007186,GO:0007264,GO:0016020,GO:0030424,GO:0043065,GO:0043197,GO:0050804,GO:0051056,GO:0090630,GO:0098685,GO:0098978" guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytosol|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|membrane|axon|positive regulation of apoptotic process|dendritic spine|modulation of chemical synaptic transmission|regulation of small GTPase mediated signal transduction|activation of GTPase activity|Schaffer collateral - CA1 synapse|glutamatergic synapse ABRACL 722.9931839 686.6731625 759.3132052 1.105785469 0.145071519 0.572140258 1 38.13369889 41.46207093 58527 ABRA C-terminal like GO:0032970 regulation of actin filament-based process ABRAXAS1 601.1647656 591.9954992 610.3340321 1.030977487 0.044012829 0.87321282 1 7.213176199 7.312180468 84142 "abraxas 1, BRCA1 A complex subunit" "GO:0005515,GO:0005634,GO:0005654,GO:0006302,GO:0006303,GO:0006325,GO:0008017,GO:0008608,GO:0010212,GO:0016579,GO:0016604,GO:0031593,GO:0045739,GO:0070531,GO:0070536,GO:0072425,GO:0090307" protein binding|nucleus|nucleoplasm|double-strand break repair|double-strand break repair via nonhomologous end joining|chromatin organization|microtubule binding|attachment of spindle microtubules to kinetochore|response to ionizing radiation|protein deubiquitination|nuclear body|polyubiquitin modification-dependent protein binding|positive regulation of DNA repair|BRCA1-A complex|protein K63-linked deubiquitination|signal transduction involved in G2 DNA damage checkpoint|mitotic spindle assembly hsa03440 Homologous recombination ABRAXAS2 462.526179 472.3479027 452.7044553 0.958413179 -0.061280348 0.832892639 1 8.484799539 7.995866638 23172 "abraxas 2, BRISC complex subunit" "GO:0000278,GO:0002931,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0007059,GO:0008017,GO:0008608,GO:0016579,GO:0030496,GO:0031593,GO:0031616,GO:0036449,GO:0051301,GO:0070536,GO:0070552,GO:0090307" mitotic cell cycle|response to ischemia|protein binding|nucleus|cytoplasm|centrosome|cytosol|chromosome segregation|microtubule binding|attachment of spindle microtubules to kinetochore|protein deubiquitination|midbody|polyubiquitin modification-dependent protein binding|spindle pole centrosome|microtubule minus-end|cell division|protein K63-linked deubiquitination|BRISC complex|mitotic spindle assembly ABT1 377.593439 349.5790646 405.6078134 1.160274898 0.214466656 0.468756902 1 6.339243009 7.232184144 29777 activator of basal transcription 1 "GO:0000447,GO:0000472,GO:0000480,GO:0003677,GO:0003713,GO:0003723,GO:0005515,GO:0005634,GO:0005730,GO:0006366,GO:0034462,GO:0045893" "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|DNA binding|transcription coactivator activity|RNA binding|protein binding|nucleus|nucleolus|transcription by RNA polymerase II|small-subunit processome assembly|positive regulation of transcription, DNA-templated" ABTB1 555.2525767 534.7727357 575.7324176 1.076592689 0.106472534 0.694864138 1 13.36134739 14.14401996 80325 ankyrin repeat and BTB domain containing 1 "GO:0000151,GO:0003746,GO:0005515,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006414" ubiquitin ligase complex|translation elongation factor activity|protein binding|nucleolus|cytoplasm|cytosol|plasma membrane|translational elongation ABTB2 844.8700632 959.2615998 730.4785266 0.761500853 -0.393082442 0.115779622 1 10.43711081 7.814871966 25841 ankyrin repeat and BTB domain containing 2 "GO:0003674,GO:0046982,GO:0097237" molecular_function|protein heterodimerization activity|cellular response to toxic substance ACAA1 508.3842621 465.0650055 551.7035187 1.18629334 0.246460796 0.366906689 1 11.80764253 13.77293403 30 acetyl-CoA acyltransferase 1 "GO:0000038,GO:0003985,GO:0003988,GO:0005515,GO:0005576,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0006635,GO:0008206,GO:0008775,GO:0010124,GO:0016020,GO:0016401,GO:0033540,GO:0035580,GO:0036109,GO:0043312,GO:0050633" very long-chain fatty acid metabolic process|acetyl-CoA C-acetyltransferase activity|acetyl-CoA C-acyltransferase activity|protein binding|extracellular region|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid beta-oxidation|bile acid metabolic process|acetate CoA-transferase activity|phenylacetate catabolic process|membrane|palmitoyl-CoA oxidase activity|fatty acid beta-oxidation using acyl-CoA oxidase|specific granule lumen|alpha-linolenic acid metabolic process|neutrophil degranulation|acetyl-CoA C-myristoyltransferase activity "hsa00071,hsa00280,hsa00592,hsa01040,hsa03320,hsa04146" "Fatty acid degradation|Valine, leucine and isoleucine degradation|alpha-Linolenic acid metabolism|Biosynthesis of unsaturated fatty acids|PPAR signaling pathway|Peroxisome" ACAA2 745.9175022 645.0566072 846.7783972 1.312719516 0.392558694 0.122121663 1 11.76537442 15.18619154 10449 acetyl-CoA acyltransferase 2 "GO:0003723,GO:0003985,GO:0003986,GO:0003988,GO:0005515,GO:0005739,GO:0005759,GO:0006635,GO:0006695,GO:0016290,GO:0047617,GO:0071456,GO:0102991,GO:1901029,GO:1902109" RNA binding|acetyl-CoA C-acetyltransferase activity|acetyl-CoA hydrolase activity|acetyl-CoA C-acyltransferase activity|protein binding|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|cholesterol biosynthetic process|palmitoyl-CoA hydrolase activity|acyl-CoA hydrolase activity|cellular response to hypoxia|myristoyl-CoA hydrolase activity|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|negative regulation of mitochondrial membrane permeability involved in apoptotic process "hsa00062,hsa00071,hsa00280" "Fatty acid elongation|Fatty acid degradation|Valine, leucine and isoleucine degradation" ACACA 1603.821078 1858.179194 1349.462962 0.726228647 -0.461504255 0.052513936 1 8.814115049 6.293949728 31 acetyl-CoA carboxylase alpha "GO:0001650,GO:0001894,GO:0003989,GO:0005515,GO:0005524,GO:0005829,GO:0006084,GO:0006633,GO:0006853,GO:0015629,GO:0019538,GO:0031325,GO:0042802,GO:0045540,GO:0046872,GO:0046949,GO:0051289,GO:0055088,GO:0071380,GO:2001295" fibrillar center|tissue homeostasis|acetyl-CoA carboxylase activity|protein binding|ATP binding|cytosol|acetyl-CoA metabolic process|fatty acid biosynthetic process|carnitine shuttle|actin cytoskeleton|protein metabolic process|positive regulation of cellular metabolic process|identical protein binding|regulation of cholesterol biosynthetic process|metal ion binding|fatty-acyl-CoA biosynthetic process|protein homotetramerization|lipid homeostasis|cellular response to prostaglandin E stimulus|malonyl-CoA biosynthetic process "hsa00061,hsa00620,hsa00640,hsa04152,hsa04910,hsa04922" Fatty acid biosynthesis|Pyruvate metabolism|Propanoate metabolism|AMPK signaling pathway|Insulin signaling pathway|Glucagon signaling pathway ACACB 215.733624 213.2848459 218.182402 1.022962513 0.032753278 0.940245295 1 1.122878586 1.129441386 32 acetyl-CoA carboxylase beta "GO:0003989,GO:0005515,GO:0005524,GO:0005634,GO:0005739,GO:0005741,GO:0005829,GO:0006084,GO:0006633,GO:0006853,GO:0009374,GO:0010629,GO:0010884,GO:0010906,GO:0014070,GO:0031325,GO:0031667,GO:0031999,GO:0042493,GO:0042802,GO:0043086,GO:0045540,GO:0046872,GO:0051289,GO:0060421,GO:0097009,GO:2001295" acetyl-CoA carboxylase activity|protein binding|ATP binding|nucleus|mitochondrion|mitochondrial outer membrane|cytosol|acetyl-CoA metabolic process|fatty acid biosynthetic process|carnitine shuttle|biotin binding|negative regulation of gene expression|positive regulation of lipid storage|regulation of glucose metabolic process|response to organic cyclic compound|positive regulation of cellular metabolic process|response to nutrient levels|negative regulation of fatty acid beta-oxidation|response to drug|identical protein binding|negative regulation of catalytic activity|regulation of cholesterol biosynthetic process|metal ion binding|protein homotetramerization|positive regulation of heart growth|energy homeostasis|malonyl-CoA biosynthetic process "hsa00061,hsa00620,hsa00640,hsa04152,hsa04910,hsa04920,hsa04922,hsa04931" Fatty acid biosynthesis|Pyruvate metabolism|Propanoate metabolism|AMPK signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance ACAD10 552.4729044 575.3488771 529.5969318 0.920479648 -0.119542272 0.659037553 1 7.490927574 6.779863765 80724 acyl-CoA dehydrogenase family member 10 "GO:0003995,GO:0005739,GO:0005759,GO:0006635,GO:0016787,GO:0050660" acyl-CoA dehydrogenase activity|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|hydrolase activity|flavin adenine dinucleotide binding ACAD11 758.6050297 763.6637899 753.5462695 0.986751342 -0.019241519 0.945046929 1 12.61384491 12.23844925 84129 acyl-CoA dehydrogenase family member 11 "GO:0003995,GO:0004466,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005777,GO:0006635,GO:0017099,GO:0031966,GO:0033539,GO:0050660,GO:0070991" acyl-CoA dehydrogenase activity|long-chain-acyl-CoA dehydrogenase activity|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|peroxisome|fatty acid beta-oxidation|very-long-chain-acyl-CoA dehydrogenase activity|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|flavin adenine dinucleotide binding|medium-chain-acyl-CoA dehydrogenase activity ACAD8 509.652389 498.3582498 520.9465281 1.045325383 0.063952086 0.820679764 1 6.741815931 6.929462768 27034 acyl-CoA dehydrogenase family member 8 "GO:0003995,GO:0005759,GO:0006574,GO:0006629,GO:0009083,GO:0050660,GO:0055114" acyl-CoA dehydrogenase activity|mitochondrial matrix|valine catabolic process|lipid metabolic process|branched-chain amino acid catabolic process|flavin adenine dinucleotide binding|oxidation-reduction process hsa00280 "Valine, leucine and isoleucine degradation" ACAD9 868.602052 900.9984224 836.2056817 0.928087842 -0.107666734 0.668699236 1 17.55554211 16.02044248 28976 acyl-CoA dehydrogenase family member 9 "GO:0000062,GO:0001676,GO:0004466,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0017099,GO:0030425,GO:0031966,GO:0032981,GO:0050660,GO:0051791,GO:0055114,GO:0070991" fatty-acyl-CoA binding|long-chain fatty acid metabolic process|long-chain-acyl-CoA dehydrogenase activity|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|very-long-chain-acyl-CoA dehydrogenase activity|dendrite|mitochondrial membrane|mitochondrial respiratory chain complex I assembly|flavin adenine dinucleotide binding|medium-chain fatty acid metabolic process|oxidation-reduction process|medium-chain-acyl-CoA dehydrogenase activity ACADL 12.08867696 14.56579436 9.61155956 0.65987198 -0.599741937 0.61074606 1 0.239331796 0.155285629 33 acyl-CoA dehydrogenase long chain "GO:0000062,GO:0001659,GO:0003995,GO:0004466,GO:0005515,GO:0005739,GO:0005759,GO:0006635,GO:0016401,GO:0019254,GO:0031966,GO:0033539,GO:0042413,GO:0042758,GO:0042802,GO:0044242,GO:0045717,GO:0046322,GO:0050660,GO:0055114,GO:0090181,GO:0120162" "fatty-acyl-CoA binding|temperature homeostasis|acyl-CoA dehydrogenase activity|long-chain-acyl-CoA dehydrogenase activity|protein binding|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|palmitoyl-CoA oxidase activity|carnitine metabolic process, CoA-linked|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|carnitine catabolic process|long-chain fatty acid catabolic process|identical protein binding|cellular lipid catabolic process|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|flavin adenine dinucleotide binding|oxidation-reduction process|regulation of cholesterol metabolic process|positive regulation of cold-induced thermogenesis" "hsa00071,hsa03320" Fatty acid degradation|PPAR signaling pathway ACADM 649.3408359 696.0368875 602.6447844 0.865823055 -0.207855878 0.424278232 1 15.66029065 13.33214851 34 acyl-CoA dehydrogenase medium chain "GO:0003995,GO:0005634,GO:0005739,GO:0005759,GO:0006635,GO:0019216,GO:0019254,GO:0030424,GO:0031966,GO:0033539,GO:0042802,GO:0045329,GO:0050660,GO:0051791,GO:0051793,GO:0055114,GO:0070991" "acyl-CoA dehydrogenase activity|nucleus|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|regulation of lipid metabolic process|carnitine metabolic process, CoA-linked|axon|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|identical protein binding|carnitine biosynthetic process|flavin adenine dinucleotide binding|medium-chain fatty acid metabolic process|medium-chain fatty acid catabolic process|oxidation-reduction process|medium-chain-acyl-CoA dehydrogenase activity" "hsa00071,hsa00280,hsa03320" "Fatty acid degradation|Valine, leucine and isoleucine degradation|PPAR signaling pathway" ACADS 273.6256639 256.982229 290.2690987 1.12952985 0.175722398 0.59507154 1 6.860765007 7.619762508 35 acyl-CoA dehydrogenase short chain "GO:0003995,GO:0004085,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0005813,GO:0006635,GO:0033539,GO:0046359,GO:0050660" acyl-CoA dehydrogenase activity|butyryl-CoA dehydrogenase activity|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|centrosome|fatty acid beta-oxidation|fatty acid beta-oxidation using acyl-CoA dehydrogenase|butyrate catabolic process|flavin adenine dinucleotide binding "hsa00071,hsa00280,hsa00410,hsa00640,hsa00650" "Fatty acid degradation|Valine, leucine and isoleucine degradation|beta-Alanine metabolism|Propanoate metabolism|Butanoate metabolism" ACADSB 316.6839531 340.2153396 293.1525666 0.861667692 -0.214796503 0.491385181 1 3.104765285 2.630508818 36 acyl-CoA dehydrogenase short/branched chain "GO:0003853,GO:0005739,GO:0005759,GO:0006550,GO:0006631,GO:0009083,GO:0016937,GO:0042802,GO:0050660,GO:0055114,GO:0102035" 2-methylacyl-CoA dehydrogenase activity|mitochondrion|mitochondrial matrix|isoleucine catabolic process|fatty acid metabolic process|branched-chain amino acid catabolic process|short-branched-chain-acyl-CoA dehydrogenase activity|identical protein binding|flavin adenine dinucleotide binding|oxidation-reduction process|isobutyryl-CoA:FAD oxidoreductase activity "hsa00071,hsa00280" "Fatty acid degradation|Valine, leucine and isoleucine degradation" ACADVL 5716.666397 5190.624861 6242.707934 1.202689099 0.266263746 0.270425898 1 113.437391 134.1469437 37 acyl-CoA dehydrogenase very long chain "GO:0000062,GO:0001659,GO:0003995,GO:0004466,GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0005759,GO:0006635,GO:0009409,GO:0015980,GO:0017099,GO:0030855,GO:0031314,GO:0031966,GO:0033539,GO:0036498,GO:0042645,GO:0042802,GO:0045717,GO:0046322,GO:0050660,GO:0090181" fatty-acyl-CoA binding|temperature homeostasis|acyl-CoA dehydrogenase activity|long-chain-acyl-CoA dehydrogenase activity|protein binding|nucleoplasm|nucleolus|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|response to cold|energy derivation by oxidation of organic compounds|very-long-chain-acyl-CoA dehydrogenase activity|epithelial cell differentiation|extrinsic component of mitochondrial inner membrane|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|IRE1-mediated unfolded protein response|mitochondrial nucleoid|identical protein binding|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|flavin adenine dinucleotide binding|regulation of cholesterol metabolic process hsa00071 Fatty acid degradation ACAP1 51.92695933 38.49531366 65.35860501 1.69783277 0.763694366 0.198908649 1 0.811063616 1.354007312 9744 "ArfGAP with coiled-coil, ankyrin repeat and PH domains 1" "GO:0005096,GO:0005515,GO:0015031,GO:0016020,GO:0043547,GO:0046872,GO:0055038" GTPase activator activity|protein binding|protein transport|membrane|positive regulation of GTPase activity|metal ion binding|recycling endosome membrane hsa04144 Endocytosis ACAP2 1880.732759 1911.240302 1850.225215 0.968075659 -0.046808291 0.845346668 1 12.98362808 12.35880687 23527 "ArfGAP with coiled-coil, ankyrin repeat and PH domains 2" "GO:0001726,GO:0005096,GO:0010008,GO:0016020,GO:0030029,GO:0032456,GO:0043547,GO:0046872,GO:1990090" ruffle|GTPase activator activity|endosome membrane|membrane|actin filament-based process|endocytic recycling|positive regulation of GTPase activity|metal ion binding|cellular response to nerve growth factor stimulus hsa04144 Endocytosis ACAP3 653.1313539 631.5312268 674.7314811 1.068405571 0.095459404 0.716812636 1 5.271138703 5.537474851 116983 "ArfGAP with coiled-coil, ankyrin repeat and PH domains 3" "GO:0001764,GO:0005096,GO:0010975,GO:0030426,GO:0043547,GO:0046872" neuron migration|GTPase activator activity|regulation of neuron projection development|growth cone|positive regulation of GTPase activity|metal ion binding hsa04144 Endocytosis ACAT1 1605.452739 1585.590757 1625.314722 1.0250531 0.035698647 0.883283797 1 37.37635359 37.67163519 38 acetyl-CoA acetyltransferase 1 "GO:0003985,GO:0005739,GO:0005759,GO:0006085,GO:0006550,GO:0006635,GO:0009083,GO:0015936,GO:0015937,GO:0016453,GO:0030955,GO:0034435,GO:0046356,GO:0046951,GO:0046952,GO:0070062,GO:1902224,GO:1902860" acetyl-CoA C-acetyltransferase activity|mitochondrion|mitochondrial matrix|acetyl-CoA biosynthetic process|isoleucine catabolic process|fatty acid beta-oxidation|branched-chain amino acid catabolic process|coenzyme A metabolic process|coenzyme A biosynthetic process|C-acetyltransferase activity|potassium ion binding|cholesterol esterification|acetyl-CoA catabolic process|ketone body biosynthetic process|ketone body catabolic process|extracellular exosome|ketone body metabolic process|propionyl-CoA biosynthetic process "hsa00071,hsa00072,hsa00280,hsa00310,hsa00380,hsa00620,hsa00630,hsa00640,hsa00650,hsa00900,hsa04975" "Fatty acid degradation|Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism|Butanoate metabolism|Terpenoid backbone biosynthesis|Fat digestion and absorption" ACAT2 791.8296912 702.2793708 881.3800116 1.255027626 0.327719122 0.19352475 1 20.5817459 25.39841859 39 acetyl-CoA acetyltransferase 2 "GO:0003985,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0006629,GO:0006635,GO:0006695,GO:0070062" acetyl-CoA C-acetyltransferase activity|protein binding|cytoplasm|mitochondrion|cytosol|lipid metabolic process|fatty acid beta-oxidation|cholesterol biosynthetic process|extracellular exosome "hsa00071,hsa00072,hsa00280,hsa00310,hsa00380,hsa00620,hsa00630,hsa00640,hsa00650,hsa00900,hsa04975" "Fatty acid degradation|Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism|Butanoate metabolism|Terpenoid backbone biosynthesis|Fat digestion and absorption" ACBD3 1886.173216 1826.966778 1945.379655 1.064813919 0.090601335 0.703531567 1 27.2047598 28.48326653 64746 acyl-CoA binding domain containing 3 "GO:0000062,GO:0000139,GO:0005515,GO:0005739,GO:0005794,GO:0006694,GO:0016020,GO:0016032,GO:0034237" fatty-acyl-CoA binding|Golgi membrane|protein binding|mitochondrion|Golgi apparatus|steroid biosynthetic process|membrane|viral process|protein kinase A regulatory subunit binding hsa05132 Salmonella infection ACBD4 325.8149347 340.2153396 311.4145297 0.915345352 -0.127611933 0.6842215 1 4.786888317 4.308334892 79777 acyl-CoA binding domain containing 4 "GO:0000062,GO:0008289" fatty-acyl-CoA binding|lipid binding ACBD5 584.6068479 636.7332962 532.4803996 0.83626913 -0.257960787 0.329906586 1 5.710180768 4.695340596 91452 acyl-CoA binding domain containing 5 "GO:0000062,GO:0003674,GO:0005654,GO:0005777,GO:0005778,GO:0008289,GO:0009062,GO:0016020,GO:0016021,GO:0016236,GO:0030242,GO:0035973" fatty-acyl-CoA binding|molecular_function|nucleoplasm|peroxisome|peroxisomal membrane|lipid binding|fatty acid catabolic process|membrane|integral component of membrane|macroautophagy|autophagy of peroxisome|aggrephagy ACBD6 875.7415246 873.9476614 877.5353878 1.004105196 0.005910422 0.986279272 1 36.07191063 35.61390036 84320 acyl-CoA binding domain containing 6 "GO:0000062,GO:0005515,GO:0005829,GO:0006637,GO:0008289" fatty-acyl-CoA binding|protein binding|cytosol|acyl-CoA metabolic process|lipid binding ACBD7 235.2536531 271.5480234 198.9592829 0.73268544 -0.448734149 0.189913044 1 4.300302351 3.098045068 414149 acyl-CoA binding domain containing 7 "GO:0000062,GO:0005515,GO:0008289" fatty-acyl-CoA binding|protein binding|lipid binding ACCS 168.0079491 184.1532572 151.862641 0.82465357 -0.278139912 0.479534989 1 2.92584724 2.372435258 84680 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) "GO:0005515,GO:0016847,GO:0030170,GO:0042218,GO:0042802" protein binding|1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|1-aminocyclopropane-1-carboxylate biosynthetic process|identical protein binding ACD 774.6175884 780.310412 768.9247648 0.985408823 -0.021205706 0.938549609 1 20.19579658 19.56809791 65057 ACD shelterin complex subunit and telomerase recruitment factor "GO:0000723,GO:0000781,GO:0000783,GO:0005515,GO:0005654,GO:0005697,GO:0006886,GO:0007004,GO:0016233,GO:0016604,GO:0031848,GO:0032202,GO:0032211,GO:0032212,GO:0042162,GO:0044877,GO:0051973,GO:0060381,GO:0070182,GO:0070187,GO:0070198,GO:0070200" "telomere maintenance|chromosome, telomeric region|nuclear telomere cap complex|protein binding|nucleoplasm|telomerase holoenzyme complex|intracellular protein transport|telomere maintenance via telomerase|telomere capping|nuclear body|protection from non-homologous end joining at telomere|telomere assembly|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance via telomerase|telomeric DNA binding|protein-containing complex binding|positive regulation of telomerase activity|positive regulation of single-stranded telomeric DNA binding|DNA polymerase binding|shelterin complex|protein localization to chromosome, telomeric region|establishment of protein localization to telomere" ACE 8.447228369 7.282897178 9.61155956 1.31974396 0.400258063 0.833324456 1 0.071923545 0.093332295 1636 angiotensin I converting enzyme "GO:0001822,GO:0001974,GO:0002003,GO:0002019,GO:0002446,GO:0002474,GO:0003081,GO:0003084,GO:0004175,GO:0004180,GO:0005576,GO:0005615,GO:0005764,GO:0005768,GO:0005886,GO:0006508,GO:0007283,GO:0008217,GO:0008237,GO:0008238,GO:0008240,GO:0008241,GO:0008270,GO:0009897,GO:0010608,GO:0010629,GO:0014910,GO:0016021,GO:0019229,GO:0031404,GO:0031434,GO:0031711,GO:0032091,GO:0032092,GO:0032943,GO:0042447,GO:0043171,GO:0050435,GO:0050482,GO:0051019,GO:0060047,GO:0060177,GO:0060218,GO:0061098,GO:0070062,GO:0070573,GO:0071838,GO:0097746,GO:1900086,GO:1902033,GO:1903597,GO:2000170" kidney development|blood vessel remodeling|angiotensin maturation|regulation of renal output by angiotensin|neutrophil mediated immunity|antigen processing and presentation of peptide antigen via MHC class I|regulation of systemic arterial blood pressure by renin-angiotensin|positive regulation of systemic arterial blood pressure|endopeptidase activity|carboxypeptidase activity|extracellular region|extracellular space|lysosome|endosome|plasma membrane|proteolysis|spermatogenesis|regulation of blood pressure|metallopeptidase activity|exopeptidase activity|tripeptidyl-peptidase activity|peptidyl-dipeptidase activity|zinc ion binding|external side of plasma membrane|posttranscriptional regulation of gene expression|negative regulation of gene expression|regulation of smooth muscle cell migration|integral component of membrane|regulation of vasoconstriction|chloride ion binding|mitogen-activated protein kinase kinase binding|bradykinin receptor binding|negative regulation of protein binding|positive regulation of protein binding|mononuclear cell proliferation|hormone catabolic process|peptide catabolic process|amyloid-beta metabolic process|arachidonic acid secretion|mitogen-activated protein kinase binding|heart contraction|regulation of angiotensin metabolic process|hematopoietic stem cell differentiation|positive regulation of protein tyrosine kinase activity|extracellular exosome|metallodipeptidase activity|cell proliferation in bone marrow|blood vessel diameter maintenance|positive regulation of peptidyl-tyrosine autophosphorylation|regulation of hematopoietic stem cell proliferation|negative regulation of gap junction assembly|positive regulation of peptidyl-cysteine S-nitrosylation "hsa04614,hsa04924,hsa05142,hsa05171,hsa05410" Renin-angiotensin system|Renin secretion|Chagas disease|Coronavirus disease - COVID-19|Hypertrophic cardiomyopathy ACER2 43.35581366 40.57614142 46.13548589 1.137010181 0.185245172 0.800810665 1 0.363639646 0.406543253 340485 alkaline ceramidase 2 "GO:0000139,GO:0001953,GO:0005794,GO:0006919,GO:0006974,GO:0008284,GO:0010506,GO:0010942,GO:0017040,GO:0030148,GO:0030173,GO:0030330,GO:0032526,GO:0033629,GO:0035690,GO:0042981,GO:0046512,GO:0046514,GO:0046872,GO:0071633,GO:0090285,GO:0102121" "Golgi membrane|negative regulation of cell-matrix adhesion|Golgi apparatus|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to DNA damage stimulus|positive regulation of cell population proliferation|regulation of autophagy|positive regulation of cell death|N-acylsphingosine amidohydrolase activity|sphingolipid biosynthetic process|integral component of Golgi membrane|DNA damage response, signal transduction by p53 class mediator|response to retinoic acid|negative regulation of cell adhesion mediated by integrin|cellular response to drug|regulation of apoptotic process|sphingosine biosynthetic process|ceramide catabolic process|metal ion binding|dihydroceramidase activity|negative regulation of protein glycosylation in Golgi|ceramidase activity" "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway ACER3 1430.210354 1564.782479 1295.638229 0.827998936 -0.27229918 0.255105182 1 9.481104108 7.71897924 55331 alkaline ceramidase 3 "GO:0005509,GO:0005789,GO:0008270,GO:0008284,GO:0016021,GO:0017040,GO:0030148,GO:0030173,GO:0030176,GO:0042552,GO:0043067,GO:0046512,GO:0046514,GO:0070774,GO:0071602,GO:0071633,GO:0102121" calcium ion binding|endoplasmic reticulum membrane|zinc ion binding|positive regulation of cell population proliferation|integral component of membrane|N-acylsphingosine amidohydrolase activity|sphingolipid biosynthetic process|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|myelination|regulation of programmed cell death|sphingosine biosynthetic process|ceramide catabolic process|phytoceramidase activity|phytosphingosine biosynthetic process|dihydroceramidase activity|ceramidase activity hsa00600 Sphingolipid metabolism ACHE 12.049048 13.52538047 10.57271552 0.781694499 -0.355323209 0.80166462 1 0.261625479 0.20108898 43 acetylcholinesterase (Cartwright blood group) "GO:0001507,GO:0001540,GO:0001919,GO:0002076,GO:0003990,GO:0004104,GO:0005515,GO:0005518,GO:0005576,GO:0005604,GO:0005615,GO:0005634,GO:0005794,GO:0005886,GO:0006581,GO:0006656,GO:0007155,GO:0007399,GO:0007416,GO:0009986,GO:0016020,GO:0016787,GO:0017171,GO:0031225,GO:0031594,GO:0031623,GO:0032223,GO:0042136,GO:0042166,GO:0042803,GO:0042982,GO:0043083,GO:0043236,GO:0043621,GO:0045202,GO:0048471,GO:0050714,GO:0052689,GO:0060041,GO:0095500,GO:0120162" "acetylcholine catabolic process in synaptic cleft|amyloid-beta binding|regulation of receptor recycling|osteoblast development|acetylcholinesterase activity|cholinesterase activity|protein binding|collagen binding|extracellular region|basement membrane|extracellular space|nucleus|Golgi apparatus|plasma membrane|acetylcholine catabolic process|phosphatidylcholine biosynthetic process|cell adhesion|nervous system development|synapse assembly|cell surface|membrane|hydrolase activity|serine hydrolase activity|anchored component of membrane|neuromuscular junction|receptor internalization|negative regulation of synaptic transmission, cholinergic|neurotransmitter biosynthetic process|acetylcholine binding|protein homodimerization activity|amyloid precursor protein metabolic process|synaptic cleft|laminin binding|protein self-association|synapse|perinuclear region of cytoplasm|positive regulation of protein secretion|carboxylic ester hydrolase activity|retina development in camera-type eye|acetylcholine receptor signaling pathway|positive regulation of cold-induced thermogenesis" "hsa00564,hsa04725" Glycerophospholipid metabolism|Cholinergic synapse ACIN1 3073.469623 3247.131728 2899.807519 0.893036613 -0.163208771 0.491013183 1 26.56245437 23.32430138 22985 apoptotic chromatin condensation inducer 1 "GO:0003676,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0006397,GO:0008380,GO:0016607,GO:0016887,GO:0019899,GO:0030218,GO:0030263,GO:0045657,GO:0061574" nucleic acid binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|plasma membrane|mRNA processing|RNA splicing|nuclear speck|ATPase activity|enzyme binding|erythrocyte differentiation|apoptotic chromosome condensation|positive regulation of monocyte differentiation|ASAP complex "hsa03013,hsa03015,hsa03040" RNA transport|mRNA surveillance pathway|Spliceosome ACLY 6041.298223 6181.098877 5901.49757 0.954765113 -0.066782243 0.783261251 1 73.63256399 69.12539783 47 ATP citrate lyase "GO:0003878,GO:0005515,GO:0005524,GO:0005576,GO:0005654,GO:0005829,GO:0005886,GO:0006085,GO:0006101,GO:0006107,GO:0006633,GO:0006695,GO:0008610,GO:0015936,GO:0016020,GO:0031325,GO:0035578,GO:0043312,GO:0046872,GO:0046949,GO:0070062,GO:1904813" ATP citrate synthase activity|protein binding|ATP binding|extracellular region|nucleoplasm|cytosol|plasma membrane|acetyl-CoA biosynthetic process|citrate metabolic process|oxaloacetate metabolic process|fatty acid biosynthetic process|cholesterol biosynthetic process|lipid biosynthetic process|coenzyme A metabolic process|membrane|positive regulation of cellular metabolic process|azurophil granule lumen|neutrophil degranulation|metal ion binding|fatty-acyl-CoA biosynthetic process|extracellular exosome|ficolin-1-rich granule lumen hsa00020 Citrate cycle (TCA cycle) ACO1 5722.04096 6164.452255 5279.629666 0.856463713 -0.223535972 0.354824664 1 90.67957195 76.36416499 48 aconitase 1 "GO:0003723,GO:0003994,GO:0005515,GO:0005737,GO:0005739,GO:0005783,GO:0005794,GO:0005829,GO:0006099,GO:0006101,GO:0006417,GO:0006879,GO:0009791,GO:0010040,GO:0030350,GO:0046872,GO:0047780,GO:0050892,GO:0051538,GO:0051539,GO:0070062" "RNA binding|aconitate hydratase activity|protein binding|cytoplasm|mitochondrion|endoplasmic reticulum|Golgi apparatus|cytosol|tricarboxylic acid cycle|citrate metabolic process|regulation of translation|cellular iron ion homeostasis|post-embryonic development|response to iron(II) ion|iron-responsive element binding|metal ion binding|citrate dehydratase activity|intestinal absorption|3 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding|extracellular exosome" "hsa00020,hsa00630" Citrate cycle (TCA cycle)|Glyoxylate and dicarboxylate metabolism ACO2 2256.319598 2271.223506 2241.415689 0.986875877 -0.019059452 0.937698085 1 36.54236484 35.4593166 50 aconitase 2 "GO:0003994,GO:0005506,GO:0005739,GO:0005759,GO:0005829,GO:0006091,GO:0006099,GO:0006101,GO:0047780,GO:0051539" "aconitate hydratase activity|iron ion binding|mitochondrion|mitochondrial matrix|cytosol|generation of precursor metabolites and energy|tricarboxylic acid cycle|citrate metabolic process|citrate dehydratase activity|4 iron, 4 sulfur cluster binding" "hsa00020,hsa00630" Citrate cycle (TCA cycle)|Glyoxylate and dicarboxylate metabolism ACOD1 18.73248031 24.96993318 12.49502743 0.500402918 -0.998837892 0.259562808 1 0.620679758 0.30539266 730249 aconitate decarboxylase 1 "GO:0002760,GO:0005739,GO:0006952,GO:0006954,GO:0007566,GO:0032088,GO:0032480,GO:0034136,GO:0034144,GO:0035458,GO:0045824,GO:0047613,GO:0050728,GO:0051607,GO:0071219,GO:0071222,GO:0071346,GO:0071347,GO:0071356,GO:0071393,GO:0072573,GO:2000379" positive regulation of antimicrobial humoral response|mitochondrion|defense response|inflammatory response|embryo implantation|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 4 signaling pathway|cellular response to interferon-beta|negative regulation of innate immune response|aconitate decarboxylase activity|negative regulation of inflammatory response|defense response to virus|cellular response to molecule of bacterial origin|cellular response to lipopolysaccharide|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to progesterone stimulus|tolerance induction to lipopolysaccharide|positive regulation of reactive oxygen species metabolic process ACOT1 78.97772028 92.59683556 65.35860501 0.70584059 -0.5025857 0.32649379 1 1.889760202 1.311548956 641371 acyl-CoA thioesterase 1 "GO:0000038,GO:0001676,GO:0005829,GO:0006631,GO:0006637,GO:0016290,GO:0047617,GO:0052689,GO:0102991" very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|cytosol|fatty acid metabolic process|acyl-CoA metabolic process|palmitoyl-CoA hydrolase activity|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity|myristoyl-CoA hydrolase activity "hsa00062,hsa01040,hsa04913" Fatty acid elongation|Biosynthesis of unsaturated fatty acids|Ovarian steroidogenesis ACOT11 12.24719281 18.72744989 5.766935736 0.307940257 -1.699277611 0.112367018 1 0.129094495 0.039088173 26027 acyl-CoA thioesterase 11 "GO:0005759,GO:0005829,GO:0006631,GO:0006637,GO:0008289,GO:0009266,GO:0009409,GO:0016290,GO:0035556,GO:0036042,GO:0047617,GO:0052689,GO:0070062,GO:0102991,GO:0120163" mitochondrial matrix|cytosol|fatty acid metabolic process|acyl-CoA metabolic process|lipid binding|response to temperature stimulus|response to cold|palmitoyl-CoA hydrolase activity|intracellular signal transduction|long-chain fatty acyl-CoA binding|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity|extracellular exosome|myristoyl-CoA hydrolase activity|negative regulation of cold-induced thermogenesis ACOT13 105.9643146 107.1626299 104.7659992 0.977635574 -0.032631312 0.965969986 1 1.320801987 1.269655471 55856 acyl-CoA thioesterase 13 "GO:0005515,GO:0005634,GO:0005739,GO:0005819,GO:0005829,GO:0006637,GO:0016290,GO:0046872,GO:0047617,GO:0051289,GO:0102991,GO:0120163" protein binding|nucleus|mitochondrion|spindle|cytosol|acyl-CoA metabolic process|palmitoyl-CoA hydrolase activity|metal ion binding|acyl-CoA hydrolase activity|protein homotetramerization|myristoyl-CoA hydrolase activity|negative regulation of cold-induced thermogenesis ACOT2 179.9381102 194.5573961 165.3188244 0.849717501 -0.234944815 0.541334897 1 5.470585167 4.57066641 10965 acyl-CoA thioesterase 2 "GO:0000038,GO:0001676,GO:0005515,GO:0005739,GO:0005759,GO:0005782,GO:0005829,GO:0006625,GO:0006631,GO:0006637,GO:0016290,GO:0047617,GO:0052689,GO:0102991" very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|protein binding|mitochondrion|mitochondrial matrix|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid metabolic process|acyl-CoA metabolic process|palmitoyl-CoA hydrolase activity|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity|myristoyl-CoA hydrolase activity "hsa00062,hsa01040,hsa04913" Fatty acid elongation|Biosynthesis of unsaturated fatty acids|Ovarian steroidogenesis ACOT4 51.20357716 44.73779695 57.66935736 1.28905224 0.366310731 0.553372692 1 1.629743344 2.065669858 122970 acyl-CoA thioesterase 4 "GO:0000038,GO:0001676,GO:0004778,GO:0005777,GO:0005782,GO:0005829,GO:0006104,GO:0006625,GO:0006631,GO:0006633,GO:0006637,GO:0016290,GO:0019605,GO:0032788,GO:0032789,GO:0043648,GO:0043649,GO:0044466,GO:0046459,GO:0047617,GO:0052689,GO:0102991" very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|succinyl-CoA hydrolase activity|peroxisome|peroxisomal matrix|cytosol|succinyl-CoA metabolic process|protein targeting to peroxisome|fatty acid metabolic process|fatty acid biosynthetic process|acyl-CoA metabolic process|palmitoyl-CoA hydrolase activity|butyrate metabolic process|saturated monocarboxylic acid metabolic process|unsaturated monocarboxylic acid metabolic process|dicarboxylic acid metabolic process|dicarboxylic acid catabolic process|glutaryl-CoA hydrolase activity|short-chain fatty acid metabolic process|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity|myristoyl-CoA hydrolase activity "hsa00062,hsa01040,hsa04913" Fatty acid elongation|Biosynthesis of unsaturated fatty acids|Ovarian steroidogenesis ACOT7 2325.959974 2080.827765 2571.092182 1.235610282 0.305223782 0.196675863 1 47.66092422 57.90487814 11332 acyl-CoA thioesterase 7 "GO:0000062,GO:0005515,GO:0005654,GO:0005739,GO:0005829,GO:0006631,GO:0006637,GO:0015937,GO:0016290,GO:0036042,GO:0036114,GO:0036116,GO:0042803,GO:0047617,GO:0051792,GO:0052689,GO:0070062,GO:0102991,GO:1900535" fatty-acyl-CoA binding|protein binding|nucleoplasm|mitochondrion|cytosol|fatty acid metabolic process|acyl-CoA metabolic process|coenzyme A biosynthetic process|palmitoyl-CoA hydrolase activity|long-chain fatty acyl-CoA binding|medium-chain fatty-acyl-CoA catabolic process|long-chain fatty-acyl-CoA catabolic process|protein homodimerization activity|acyl-CoA hydrolase activity|medium-chain fatty acid biosynthetic process|carboxylic ester hydrolase activity|extracellular exosome|myristoyl-CoA hydrolase activity|palmitic acid biosynthetic process "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids ACOT8 391.4559729 335.0132702 447.8986755 1.336958011 0.418954157 0.150007842 1 14.96154184 19.6682309 10005 acyl-CoA thioesterase 8 "GO:0003986,GO:0004778,GO:0005515,GO:0005782,GO:0005829,GO:0006625,GO:0006637,GO:0006699,GO:0009062,GO:0016032,GO:0016289,GO:0016290,GO:0016559,GO:0033540,GO:0033882,GO:0036109,GO:0043649,GO:0044466,GO:0045225,GO:0047603,GO:0047617,GO:0047994,GO:0052689,GO:0052815,GO:0052816,GO:0102991" acetyl-CoA hydrolase activity|succinyl-CoA hydrolase activity|protein binding|peroxisomal matrix|cytosol|protein targeting to peroxisome|acyl-CoA metabolic process|bile acid biosynthetic process|fatty acid catabolic process|viral process|CoA hydrolase activity|palmitoyl-CoA hydrolase activity|peroxisome fission|fatty acid beta-oxidation using acyl-CoA oxidase|choloyl-CoA hydrolase activity|alpha-linolenic acid metabolic process|dicarboxylic acid catabolic process|glutaryl-CoA hydrolase activity|negative regulation of CD4 production|acetoacetyl-CoA hydrolase activity|acyl-CoA hydrolase activity|hydroxymethylglutaryl-CoA hydrolase activity|carboxylic ester hydrolase activity|medium-chain acyl-CoA hydrolase activity|long-chain acyl-CoA hydrolase activity|myristoyl-CoA hydrolase activity "hsa00120,hsa04146" Primary bile acid biosynthesis|Peroxisome ACOT9 2550.844087 2345.092891 2756.595282 1.175473812 0.233242399 0.323983639 1 28.98408928 33.49992199 23597 acyl-CoA thioesterase 9 "GO:0003986,GO:0005739,GO:0005759,GO:0006637,GO:0047617,GO:0052689" acetyl-CoA hydrolase activity|mitochondrion|mitochondrial matrix|acyl-CoA metabolic process|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity ACOX1 751.6592859 707.4814402 795.8371316 1.124887646 0.169780911 0.505333569 1 4.934263482 5.457612064 51 acyl-CoA oxidase 1 "GO:0000038,GO:0003997,GO:0005504,GO:0005777,GO:0005778,GO:0005782,GO:0005829,GO:0006091,GO:0006625,GO:0006629,GO:0006693,GO:0007283,GO:0009062,GO:0016020,GO:0016401,GO:0019216,GO:0019395,GO:0030165,GO:0033540,GO:0036109,GO:0042803,GO:0047485,GO:0050660,GO:0050665,GO:0055088,GO:0071949" very long-chain fatty acid metabolic process|acyl-CoA oxidase activity|fatty acid binding|peroxisome|peroxisomal membrane|peroxisomal matrix|cytosol|generation of precursor metabolites and energy|protein targeting to peroxisome|lipid metabolic process|prostaglandin metabolic process|spermatogenesis|fatty acid catabolic process|membrane|palmitoyl-CoA oxidase activity|regulation of lipid metabolic process|fatty acid oxidation|PDZ domain binding|fatty acid beta-oxidation using acyl-CoA oxidase|alpha-linolenic acid metabolic process|protein homodimerization activity|protein N-terminus binding|flavin adenine dinucleotide binding|hydrogen peroxide biosynthetic process|lipid homeostasis|FAD binding "hsa00071,hsa00410,hsa00592,hsa00640,hsa01040,hsa03320,hsa04024,hsa04146" Fatty acid degradation|beta-Alanine metabolism|alpha-Linolenic acid metabolism|Propanoate metabolism|Biosynthesis of unsaturated fatty acids|PPAR signaling pathway|cAMP signaling pathway|Peroxisome ACOX2 27.82383292 23.9295193 31.71814655 1.325481977 0.406517053 0.613725158 1 0.545292256 0.710680396 8309 acyl-CoA oxidase 2 "GO:0000038,GO:0003997,GO:0005504,GO:0005515,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0006699,GO:0010942,GO:0016401,GO:0033540,GO:0033791,GO:0042803,GO:0043231,GO:0050660,GO:0055088,GO:0071949,GO:1902884" "very long-chain fatty acid metabolic process|acyl-CoA oxidase activity|fatty acid binding|protein binding|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|bile acid biosynthetic process|positive regulation of cell death|palmitoyl-CoA oxidase activity|fatty acid beta-oxidation using acyl-CoA oxidase|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|protein homodimerization activity|intracellular membrane-bounded organelle|flavin adenine dinucleotide binding|lipid homeostasis|FAD binding|positive regulation of response to oxidative stress" "hsa00120,hsa03320,hsa04146" Primary bile acid biosynthesis|PPAR signaling pathway|Peroxisome ACOX3 378.9112556 358.9427895 398.8797217 1.111262667 0.152199865 0.609313637 1 3.824339582 4.178730391 8310 "acyl-CoA oxidase 3, pristanoyl" "GO:0003997,GO:0005504,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0016020,GO:0016402,GO:0033540,GO:0050660,GO:0055088,GO:0071949" acyl-CoA oxidase activity|fatty acid binding|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|membrane|pristanoyl-CoA oxidase activity|fatty acid beta-oxidation using acyl-CoA oxidase|flavin adenine dinucleotide binding|lipid homeostasis|FAD binding "hsa00071,hsa00410,hsa00592,hsa00640,hsa01040,hsa03320,hsa04024,hsa04146" Fatty acid degradation|beta-Alanine metabolism|alpha-Linolenic acid metabolism|Propanoate metabolism|Biosynthesis of unsaturated fatty acids|PPAR signaling pathway|cAMP signaling pathway|Peroxisome ACP1 1400.004367 1389.992947 1410.015787 1.014404994 0.020633753 0.934501552 1 41.0977113 40.99210252 52 acid phosphatase 1 "GO:0003993,GO:0004725,GO:0004726,GO:0005515,GO:0005737,GO:0009898,GO:0035335,GO:0070062" acid phosphatase activity|protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|protein binding|cytoplasm|cytoplasmic side of plasma membrane|peptidyl-tyrosine dephosphorylation|extracellular exosome "hsa00730,hsa00740,hsa04520" Thiamine metabolism|Riboflavin metabolism|Adherens junction ACP2 321.182762 306.9220954 335.4434286 1.092926947 0.128196972 0.684362715 1 7.263799615 7.80595723 53 "acid phosphatase 2, lysosomal" "GO:0003993,GO:0005515,GO:0005764,GO:0005765,GO:0007040,GO:0016020,GO:0016021,GO:0016311,GO:0016791,GO:0043202,GO:0070062" acid phosphatase activity|protein binding|lysosome|lysosomal membrane|lysosome organization|membrane|integral component of membrane|dephosphorylation|phosphatase activity|lysosomal lumen|extracellular exosome "hsa00740,hsa04142" Riboflavin metabolism|Lysosome ACP5 8.685002149 13.52538047 3.844623824 0.284252545 -1.814754828 0.153112967 1 0.359474451 0.100471658 54 "acid phosphatase 5, tartrate resistant" "GO:0001503,GO:0003993,GO:0005764,GO:0005829,GO:0006771,GO:0008198,GO:0008199,GO:0016021,GO:0016311,GO:0045453" ossification|acid phosphatase activity|lysosome|cytosol|riboflavin metabolic process|ferrous iron binding|ferric iron binding|integral component of membrane|dephosphorylation|bone resorption "hsa00740,hsa04142,hsa04380,hsa05323" Riboflavin metabolism|Lysosome|Osteoclast differentiation|Rheumatoid arthritis ACP6 282.4194921 298.5987843 266.2401998 0.891631895 -0.165479871 0.613389518 1 1.244487959 1.091057083 51205 "acid phosphatase 6, lysophosphatidic" "GO:0002244,GO:0003993,GO:0005737,GO:0005739,GO:0005759,GO:0006644,GO:0006654,GO:0016311,GO:0016791,GO:0052642,GO:2001311" hematopoietic progenitor cell differentiation|acid phosphatase activity|cytoplasm|mitochondrion|mitochondrial matrix|phospholipid metabolic process|phosphatidic acid biosynthetic process|dephosphorylation|phosphatase activity|lysophosphatidic acid phosphatase activity|lysobisphosphatidic acid metabolic process ACP7 195.8814719 184.1532572 207.6096865 1.127374501 0.172966842 0.645628828 1 2.441719473 2.706669026 390928 "acid phosphatase 7, tartrate resistant (putative)" "GO:0003993,GO:0005576,GO:0016311,GO:0046872" acid phosphatase activity|extracellular region|dephosphorylation|metal ion binding ACRBP 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.087440908 0.052951992 84519 acrosin binding protein "GO:0001669,GO:0001675,GO:0002080,GO:0003674,GO:0005576,GO:0005634,GO:0007286,GO:0008150,GO:0009566" acrosomal vesicle|acrosome assembly|acrosomal membrane|molecular_function|extracellular region|nucleus|spermatid development|biological_process|fertilization ACSF2 498.2770333 502.5199053 494.0341614 0.983113616 -0.02456994 0.936231919 1 11.38309158 11.00360823 80221 acyl-CoA synthetase family member 2 "GO:0005515,GO:0005524,GO:0005759,GO:0006631,GO:0006637,GO:0031956,GO:0047760" protein binding|ATP binding|mitochondrial matrix|fatty acid metabolic process|acyl-CoA metabolic process|medium-chain fatty acid-CoA ligase activity|butyrate-CoA ligase activity ACSF3 458.8451014 464.0245917 453.6656112 0.977675794 -0.03257196 0.915143641 1 1.535855843 1.476442356 197322 acyl-CoA synthetase family member 3 "GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0006631,GO:0006633,GO:0016405,GO:0016878,GO:0031957,GO:0035338,GO:0090409,GO:0090410" protein binding|ATP binding|mitochondrion|mitochondrial matrix|fatty acid metabolic process|fatty acid biosynthetic process|CoA-ligase activity|acid-thiol ligase activity|very long-chain fatty acid-CoA ligase activity|long-chain fatty-acyl-CoA biosynthetic process|malonyl-CoA synthetase activity|malonate catabolic process "hsa00061,hsa00280" "Fatty acid biosynthesis|Valine, leucine and isoleucine degradation" ACSL1 1252.14045 1305.719423 1198.561477 0.917931874 -0.123541009 0.610394943 1 14.89926145 13.44764916 2180 acyl-CoA synthetase long chain family member 1 "GO:0000038,GO:0001676,GO:0004467,GO:0005524,GO:0005739,GO:0005741,GO:0005778,GO:0005783,GO:0005789,GO:0005886,GO:0007584,GO:0008610,GO:0010747,GO:0014070,GO:0015908,GO:0016020,GO:0016021,GO:0019216,GO:0019432,GO:0033211,GO:0034201,GO:0035338,GO:0036109,GO:0042178,GO:0042493,GO:0043651,GO:0044539,GO:0047676,GO:0050197,GO:0071902,GO:0090434,GO:0120162" very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|ATP binding|mitochondrion|mitochondrial outer membrane|peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|response to nutrient|lipid biosynthetic process|positive regulation of long-chain fatty acid import across plasma membrane|response to organic cyclic compound|fatty acid transport|membrane|integral component of membrane|regulation of lipid metabolic process|triglyceride biosynthetic process|adiponectin-activated signaling pathway|response to oleic acid|long-chain fatty-acyl-CoA biosynthetic process|alpha-linolenic acid metabolic process|xenobiotic catabolic process|response to drug|linoleic acid metabolic process|long-chain fatty acid import into cell|arachidonate-CoA ligase activity|phytanate-CoA ligase activity|positive regulation of protein serine/threonine kinase activity|oleoyl-CoA ligase activity|positive regulation of cold-induced thermogenesis "hsa00061,hsa00071,hsa03320,hsa04146,hsa04216,hsa04714,hsa04920" Fatty acid biosynthesis|Fatty acid degradation|PPAR signaling pathway|Peroxisome|Ferroptosis|Thermogenesis|Adipocytokine signaling pathway ACSL3 2674.886696 2510.518699 2839.254694 1.130943456 0.177526801 0.453156456 1 24.0239858 26.71512024 2181 acyl-CoA synthetase long chain family member 3 "GO:0001676,GO:0004467,GO:0005515,GO:0005524,GO:0005741,GO:0005778,GO:0005783,GO:0005789,GO:0005794,GO:0005811,GO:0005886,GO:0006633,GO:0007420,GO:0007584,GO:0014070,GO:0016020,GO:0016021,GO:0019901,GO:0019904,GO:0030182,GO:0034379,GO:0035336,GO:0035338,GO:0042998,GO:0044539,GO:0047676,GO:0048471,GO:0051047,GO:2001247" long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|protein binding|ATP binding|mitochondrial outer membrane|peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|lipid droplet|plasma membrane|fatty acid biosynthetic process|brain development|response to nutrient|response to organic cyclic compound|membrane|integral component of membrane|protein kinase binding|protein domain specific binding|neuron differentiation|very-low-density lipoprotein particle assembly|long-chain fatty-acyl-CoA metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of Golgi to plasma membrane protein transport|long-chain fatty acid import into cell|arachidonate-CoA ligase activity|perinuclear region of cytoplasm|positive regulation of secretion|positive regulation of phosphatidylcholine biosynthetic process "hsa00061,hsa00071,hsa03320,hsa04146,hsa04216,hsa04714,hsa04920" Fatty acid biosynthesis|Fatty acid degradation|PPAR signaling pathway|Peroxisome|Ferroptosis|Thermogenesis|Adipocytokine signaling pathway ACSL4 4861.41992 4539.32577 5183.514071 1.141912771 0.19145245 0.424695258 1 48.26767751 54.19516106 2182 acyl-CoA synthetase long chain family member 4 "GO:0001676,GO:0004467,GO:0005524,GO:0005737,GO:0005741,GO:0005778,GO:0005783,GO:0005789,GO:0005811,GO:0005886,GO:0006629,GO:0007584,GO:0015908,GO:0016020,GO:0016021,GO:0019432,GO:0030182,GO:0031957,GO:0032024,GO:0035336,GO:0035338,GO:0043025,GO:0044233,GO:0047676,GO:0060136,GO:0060996,GO:0070062,GO:0070672" long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|ATP binding|cytoplasm|mitochondrial outer membrane|peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|plasma membrane|lipid metabolic process|response to nutrient|fatty acid transport|membrane|integral component of membrane|triglyceride biosynthetic process|neuron differentiation|very long-chain fatty acid-CoA ligase activity|positive regulation of insulin secretion|long-chain fatty-acyl-CoA metabolic process|long-chain fatty-acyl-CoA biosynthetic process|neuronal cell body|mitochondria-associated endoplasmic reticulum membrane|arachidonate-CoA ligase activity|embryonic process involved in female pregnancy|dendritic spine development|extracellular exosome|response to interleukin-15 "hsa00061,hsa00071,hsa03320,hsa04146,hsa04216,hsa04714,hsa04920" Fatty acid biosynthesis|Fatty acid degradation|PPAR signaling pathway|Peroxisome|Ferroptosis|Thermogenesis|Adipocytokine signaling pathway ACSL5 113.4950464 103.0009744 123.9891183 1.20376646 0.267555525 0.55978159 1 1.457309834 1.724905523 51703 acyl-CoA synthetase long chain family member 5 "GO:0001676,GO:0004467,GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005739,GO:0005741,GO:0005783,GO:0005789,GO:0005886,GO:0008610,GO:0010747,GO:0016020,GO:0016021,GO:0035338,GO:0047676" long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|protein binding|ATP binding|nucleoplasm|nucleolus|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|lipid biosynthetic process|positive regulation of long-chain fatty acid import across plasma membrane|membrane|integral component of membrane|long-chain fatty-acyl-CoA biosynthetic process|arachidonate-CoA ligase activity "hsa00061,hsa00071,hsa03320,hsa04146,hsa04216,hsa04714,hsa04920" Fatty acid biosynthesis|Fatty acid degradation|PPAR signaling pathway|Peroxisome|Ferroptosis|Thermogenesis|Adipocytokine signaling pathway ACSM3 30.74189934 37.45489978 24.0288989 0.641542203 -0.640383922 0.38284597 1 0.603168124 0.380482592 6296 acyl-CoA synthetase medium chain family member 3 "GO:0001676,GO:0004321,GO:0004467,GO:0005524,GO:0005739,GO:0005759,GO:0006633,GO:0006637,GO:0008217,GO:0015645,GO:0031956,GO:0042632,GO:0046872,GO:0047760,GO:0050218" long-chain fatty acid metabolic process|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|ATP binding|mitochondrion|mitochondrial matrix|fatty acid biosynthetic process|acyl-CoA metabolic process|regulation of blood pressure|fatty acid ligase activity|medium-chain fatty acid-CoA ligase activity|cholesterol homeostasis|metal ion binding|butyrate-CoA ligase activity|propionate-CoA ligase activity hsa00650 Butanoate metabolism ACSS1 196.0299269 213.2848459 178.7750078 0.838198359 -0.254636398 0.492077712 1 2.863552258 2.360060292 84532 acyl-CoA synthetase short chain family member 1 "GO:0003987,GO:0005515,GO:0005524,GO:0005759,GO:0006069,GO:0006085,GO:0016208,GO:0019413,GO:0019427,GO:0019542,GO:0050218" acetate-CoA ligase activity|protein binding|ATP binding|mitochondrial matrix|ethanol oxidation|acetyl-CoA biosynthetic process|AMP binding|acetate biosynthetic process|acetyl-CoA biosynthetic process from acetate|propionate biosynthetic process|propionate-CoA ligase activity "hsa00010,hsa00620,hsa00630,hsa00640" Glycolysis / Gluconeogenesis|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism ACSS2 1145.101123 1182.950585 1107.251661 0.936008381 -0.095406647 0.69700912 1 19.55153253 17.99416592 55902 acyl-CoA synthetase short chain family member 2 "GO:0003987,GO:0005524,GO:0005654,GO:0005737,GO:0005759,GO:0005829,GO:0006069,GO:0008610,GO:0016208,GO:0019413,GO:0019427,GO:0019542,GO:0043231,GO:0050218" acetate-CoA ligase activity|ATP binding|nucleoplasm|cytoplasm|mitochondrial matrix|cytosol|ethanol oxidation|lipid biosynthetic process|AMP binding|acetate biosynthetic process|acetyl-CoA biosynthetic process from acetate|propionate biosynthetic process|intracellular membrane-bounded organelle|propionate-CoA ligase activity "hsa00010,hsa00620,hsa00630,hsa00640" Glycolysis / Gluconeogenesis|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism ACTA2 325.6174042 234.0931236 417.1416849 1.781947622 0.833454931 0.00677629 0.495538837 6.909911372 12.10705708 59 "actin alpha 2, smooth muscle" "GO:0005524,GO:0005615,GO:0005737,GO:0005829,GO:0005869,GO:0006936,GO:0008217,GO:0009615,GO:0010628,GO:0014829,GO:0019901,GO:0030027,GO:0030175,GO:0030485,GO:0032991,GO:0044297,GO:0045893,GO:0070062,GO:0072144,GO:0090131" "ATP binding|extracellular space|cytoplasm|cytosol|dynactin complex|muscle contraction|regulation of blood pressure|response to virus|positive regulation of gene expression|vascular associated smooth muscle contraction|protein kinase binding|lamellipodium|filopodium|smooth muscle contractile fiber|protein-containing complex|cell body|positive regulation of transcription, DNA-templated|extracellular exosome|glomerular mesangial cell development|mesenchyme migration" "hsa04270,hsa04371,hsa04926" Vascular smooth muscle contraction|Apelin signaling pathway|Relaxin signaling pathway ACTB 71283.93238 62814.98816 79752.8766 1.269647244 0.344427717 0.332337258 1 1850.066484 2309.62562 60 actin beta "GO:0000079,GO:0000785,GO:0001738,GO:0001895,GO:0005200,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005884,GO:0005886,GO:0005911,GO:0005912,GO:0005925,GO:0007163,GO:0007409,GO:0015629,GO:0016020,GO:0016579,GO:0019894,GO:0019901,GO:0021762,GO:0022898,GO:0030027,GO:0030424,GO:0030957,GO:0031492,GO:0031982,GO:0032091,GO:0032991,GO:0034329,GO:0034333,GO:0035267,GO:0035633,GO:0036464,GO:0038096,GO:0042802,GO:0043044,GO:0043296,GO:0045176,GO:0045202,GO:0045815,GO:0048013,GO:0048156,GO:0048870,GO:0050998,GO:0051621,GO:0051623,GO:0061024,GO:0070062,GO:0070160,GO:0070527,GO:0071896,GO:0072562,GO:0072749,GO:0097433,GO:0098793,GO:0098871,GO:0098973,GO:0098974,GO:0098978,GO:0150111,GO:1903076,GO:1990904" "regulation of cyclin-dependent protein serine/threonine kinase activity|chromatin|morphogenesis of a polarized epithelium|retina homeostasis|structural constituent of cytoskeleton|protein binding|ATP binding|extracellular space|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|actin filament|plasma membrane|cell-cell junction|adherens junction|focal adhesion|establishment or maintenance of cell polarity|axonogenesis|actin cytoskeleton|membrane|protein deubiquitination|kinesin binding|protein kinase binding|substantia nigra development|regulation of transmembrane transporter activity|lamellipodium|axon|Tat protein binding|nucleosomal DNA binding|vesicle|negative regulation of protein binding|protein-containing complex|cell junction assembly|adherens junction assembly|NuA4 histone acetyltransferase complex|maintenance of blood-brain barrier|cytoplasmic ribonucleoprotein granule|Fc-gamma receptor signaling pathway involved in phagocytosis|identical protein binding|ATP-dependent chromatin remodeling|apical junction complex|apical protein localization|synapse|positive regulation of gene expression, epigenetic|ephrin receptor signaling pathway|tau protein binding|cell motility|nitric-oxide synthase binding|regulation of norepinephrine uptake|positive regulation of norepinephrine uptake|membrane organization|extracellular exosome|tight junction|platelet aggregation|protein localization to adherens junction|blood microparticle|cellular response to cytochalasin B|dense body|presynapse|postsynaptic actin cytoskeleton|structural constituent of postsynaptic actin cytoskeleton|postsynaptic actin cytoskeleton organization|glutamatergic synapse|regulation of transepithelial transport|regulation of protein localization to plasma membrane|ribonucleoprotein complex" "hsa04015,hsa04145,hsa04210,hsa04390,hsa04510,hsa04520,hsa04530,hsa04611,hsa04670,hsa04714,hsa04810,hsa04919,hsa04921,hsa04971,hsa05014,hsa05100,hsa05110,hsa05130,hsa05131,hsa05132,hsa05135,hsa05164,hsa05205,hsa05225,hsa05410,hsa05412,hsa05414,hsa05416,hsa05418" Rap1 signaling pathway|Phagosome|Apoptosis|Hippo signaling pathway|Focal adhesion|Adherens junction|Tight junction|Platelet activation|Leukocyte transendothelial migration|Thermogenesis|Regulation of actin cytoskeleton|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Gastric acid secretion|Amyotrophic lateral sclerosis|Bacterial invasion of epithelial cells|Vibrio cholerae infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Influenza A|Proteoglycans in cancer|Hepatocellular carcinoma|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Viral myocarditis|Fluid shear stress and atherosclerosis ACTBL2 18.93062512 30.1720026 7.689247648 0.254847109 -1.972296105 0.028006309 0.877967194 0.576315077 0.144414524 345651 actin beta like 2 "GO:0003674,GO:0005515,GO:0005524,GO:0005615,GO:0005737,GO:0005884,GO:0007409,GO:0008150,GO:0016020,GO:0019901,GO:0030424,GO:0035267,GO:0045202,GO:0048870,GO:0070062,GO:0098973,GO:0098974,GO:0098978" molecular_function|protein binding|ATP binding|extracellular space|cytoplasm|actin filament|axonogenesis|biological_process|membrane|protein kinase binding|axon|NuA4 histone acetyltransferase complex|synapse|cell motility|extracellular exosome|structural constituent of postsynaptic actin cytoskeleton|postsynaptic actin cytoskeleton organization|glutamatergic synapse ACTC1 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.120531787 0.072990987 70 actin alpha cardiac muscle 1 "GO:0005524,GO:0005615,GO:0005737,GO:0005829,GO:0005869,GO:0005884,GO:0005925,GO:0007015,GO:0010628,GO:0016020,GO:0016887,GO:0017022,GO:0030017,GO:0030027,GO:0030048,GO:0030049,GO:0030175,GO:0030240,GO:0031032,GO:0031674,GO:0033275,GO:0042493,GO:0044297,GO:0045471,GO:0055003,GO:0055008,GO:0060047,GO:0060048,GO:0070062,GO:0072562,GO:0090131" ATP binding|extracellular space|cytoplasm|cytosol|dynactin complex|actin filament|focal adhesion|actin filament organization|positive regulation of gene expression|membrane|ATPase activity|myosin binding|sarcomere|lamellipodium|actin filament-based movement|muscle filament sliding|filopodium|skeletal muscle thin filament assembly|actomyosin structure organization|I band|actin-myosin filament sliding|response to drug|cell body|response to ethanol|cardiac myofibril assembly|cardiac muscle tissue morphogenesis|heart contraction|cardiac muscle contraction|extracellular exosome|blood microparticle|mesenchyme migration "hsa04260,hsa04261,hsa05410,hsa05414" Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Hypertrophic cardiomyopathy|Dilated cardiomyopathy ACTG1 47269.32022 42763.0914 51775.54904 1.210753183 0.275904796 0.391629534 1 1119.817268 1333.134472 71 actin gamma 1 "GO:0001525,GO:0001738,GO:0001895,GO:0005200,GO:0005515,GO:0005522,GO:0005524,GO:0005615,GO:0005634,GO:0005829,GO:0005856,GO:0005884,GO:0005886,GO:0005911,GO:0005925,GO:0010628,GO:0016020,GO:0030335,GO:0031625,GO:0034329,GO:0035633,GO:0038096,GO:0042802,GO:0043296,GO:0048013,GO:0051492,GO:0051893,GO:0061024,GO:0070062,GO:0070527,GO:0072562,GO:0090303,GO:0097433,GO:0098973,GO:0098974,GO:0120192,GO:0150111,GO:1902396" angiogenesis|morphogenesis of a polarized epithelium|retina homeostasis|structural constituent of cytoskeleton|protein binding|profilin binding|ATP binding|extracellular space|nucleus|cytosol|cytoskeleton|actin filament|plasma membrane|cell-cell junction|focal adhesion|positive regulation of gene expression|membrane|positive regulation of cell migration|ubiquitin protein ligase binding|cell junction assembly|maintenance of blood-brain barrier|Fc-gamma receptor signaling pathway involved in phagocytosis|identical protein binding|apical junction complex|ephrin receptor signaling pathway|regulation of stress fiber assembly|regulation of focal adhesion assembly|membrane organization|extracellular exosome|platelet aggregation|blood microparticle|positive regulation of wound healing|dense body|structural constituent of postsynaptic actin cytoskeleton|postsynaptic actin cytoskeleton organization|tight junction assembly|regulation of transepithelial transport|protein localization to bicellular tight junction "hsa04015,hsa04145,hsa04210,hsa04390,hsa04510,hsa04520,hsa04530,hsa04611,hsa04670,hsa04714,hsa04810,hsa04919,hsa04921,hsa04971,hsa05014,hsa05100,hsa05110,hsa05130,hsa05131,hsa05132,hsa05135,hsa05164,hsa05205,hsa05225,hsa05410,hsa05412,hsa05414,hsa05416,hsa05418" Rap1 signaling pathway|Phagosome|Apoptosis|Hippo signaling pathway|Focal adhesion|Adherens junction|Tight junction|Platelet activation|Leukocyte transendothelial migration|Thermogenesis|Regulation of actin cytoskeleton|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Gastric acid secretion|Amyotrophic lateral sclerosis|Bacterial invasion of epithelial cells|Vibrio cholerae infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Influenza A|Proteoglycans in cancer|Hepatocellular carcinoma|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Viral myocarditis|Fluid shear stress and atherosclerosis ACTL10 14.20913369 19.76786377 8.650403604 0.437599313 -1.192317622 0.231701499 1 0.666440024 0.286753602 170487 actin like 10 GO:0005869 dynactin complex ACTL6A 1773.158748 1723.965804 1822.351693 1.057069513 0.080070252 0.737377144 1 53.80402715 55.92287743 86 actin like 6A "GO:0000785,GO:0001825,GO:0003407,GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0006281,GO:0006310,GO:0006338,GO:0006357,GO:0007165,GO:0007399,GO:0016514,GO:0016579,GO:0021510,GO:0031011,GO:0031492,GO:0032991,GO:0035267,GO:0040008,GO:0043044,GO:0043967,GO:0043968,GO:0045893,GO:0071564" "chromatin|blastocyst formation|neural retina development|chromatin binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|plasma membrane|DNA repair|DNA recombination|chromatin remodeling|regulation of transcription by RNA polymerase II|signal transduction|nervous system development|SWI/SNF complex|protein deubiquitination|spinal cord development|Ino80 complex|nucleosomal DNA binding|protein-containing complex|NuA4 histone acetyltransferase complex|regulation of growth|ATP-dependent chromatin remodeling|histone H4 acetylation|histone H2A acetylation|positive regulation of transcription, DNA-templated|npBAF complex" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma ACTN1 10789.54074 10524.82684 11054.25465 1.050302758 0.070805255 0.779893014 1 114.2809083 118.0210211 87 actinin alpha 1 "GO:0001725,GO:0001726,GO:0002576,GO:0003725,GO:0005178,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005829,GO:0005884,GO:0005886,GO:0005903,GO:0005911,GO:0005916,GO:0005925,GO:0007015,GO:0017166,GO:0030018,GO:0030168,GO:0030220,GO:0030374,GO:0031093,GO:0031143,GO:0036344,GO:0042803,GO:0042981,GO:0042995,GO:0044325,GO:0045893,GO:0048041,GO:0051015,GO:0051017,GO:0051271,GO:0051639,GO:0070062,GO:0070527,GO:0098978,GO:0099173,GO:0099186" "stress fiber|ruffle|platelet degranulation|double-stranded RNA binding|integrin binding|calcium ion binding|protein binding|extracellular region|extracellular space|cytoplasm|cytosol|actin filament|plasma membrane|brush border|cell-cell junction|fascia adherens|focal adhesion|actin filament organization|vinculin binding|Z disc|platelet activation|platelet formation|nuclear receptor coactivator activity|platelet alpha granule lumen|pseudopodium|platelet morphogenesis|protein homodimerization activity|regulation of apoptotic process|cell projection|ion channel binding|positive regulation of transcription, DNA-templated|focal adhesion assembly|actin filament binding|actin filament bundle assembly|negative regulation of cellular component movement|actin filament network formation|extracellular exosome|platelet aggregation|glutamatergic synapse|postsynapse organization|structural constituent of postsynapse" "hsa04510,hsa04520,hsa04530,hsa04670,hsa04810,hsa05131,hsa05146,hsa05203,hsa05322" Focal adhesion|Adherens junction|Tight junction|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Shigellosis|Amoebiasis|Viral carcinogenesis|Systemic lupus erythematosus ACTN2 21.37314398 31.21241648 11.53387147 0.369528309 -1.436243205 0.086041329 1 0.328614974 0.119400526 88 actinin alpha 2 "GO:0000165,GO:0002576,GO:0005178,GO:0005509,GO:0005515,GO:0005546,GO:0005576,GO:0005829,GO:0005856,GO:0005884,GO:0005886,GO:0005925,GO:0007155,GO:0008092,GO:0008307,GO:0019904,GO:0030018,GO:0030035,GO:0030049,GO:0030175,GO:0030274,GO:0030374,GO:0030864,GO:0031093,GO:0031143,GO:0031432,GO:0042391,GO:0042802,GO:0042981,GO:0043197,GO:0043267,GO:0043268,GO:0044325,GO:0045214,GO:0045893,GO:0048041,GO:0051015,GO:0051373,GO:0051695,GO:0055013,GO:0070062,GO:0070080,GO:0072659,GO:0086097,GO:0098839,GO:0098978,GO:0099092,GO:1901017,GO:1901018,GO:2000009,GO:2000310,GO:2001137,GO:2001259" "MAPK cascade|platelet degranulation|integrin binding|calcium ion binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular region|cytosol|cytoskeleton|actin filament|plasma membrane|focal adhesion|cell adhesion|cytoskeletal protein binding|structural constituent of muscle|protein domain specific binding|Z disc|microspike assembly|muscle filament sliding|filopodium|LIM domain binding|nuclear receptor coactivator activity|cortical actin cytoskeleton|platelet alpha granule lumen|pseudopodium|titin binding|regulation of membrane potential|identical protein binding|regulation of apoptotic process|dendritic spine|negative regulation of potassium ion transport|positive regulation of potassium ion transport|ion channel binding|sarcomere organization|positive regulation of transcription, DNA-templated|focal adhesion assembly|actin filament binding|FATZ binding|actin filament uncapping|cardiac muscle cell development|extracellular exosome|titin Z domain binding|protein localization to plasma membrane|phospholipase C-activating angiotensin-activated signaling pathway|postsynaptic density membrane|glutamatergic synapse|postsynaptic density, intracellular component|negative regulation of potassium ion transmembrane transporter activity|positive regulation of potassium ion transmembrane transporter activity|negative regulation of protein localization to cell surface|regulation of NMDA receptor activity|positive regulation of endocytic recycling|positive regulation of cation channel activity" hsa05412 Arrhythmogenic right ventricular cardiomyopathy ACTN3 2.923096831 1.040413883 4.80577978 4.619103859 2.207612985 0.416510993 1 0.01695937 0.077026225 89 actinin alpha 3 "GO:0003779,GO:0005178,GO:0005509,GO:0005515,GO:0005829,GO:0005884,GO:0005925,GO:0008307,GO:0014728,GO:0014732,GO:0014883,GO:0014894,GO:0030049,GO:0031143,GO:0042802,GO:0042981,GO:0044325,GO:0045820,GO:0048041,GO:0048633,GO:0070062,GO:0070885,GO:0090324,GO:0120163,GO:1903715,GO:1904025" actin binding|integrin binding|calcium ion binding|protein binding|cytosol|actin filament|focal adhesion|structural constituent of muscle|regulation of the force of skeletal muscle contraction|skeletal muscle atrophy|transition between fast and slow fiber|response to denervation involved in regulation of muscle adaptation|muscle filament sliding|pseudopodium|identical protein binding|regulation of apoptotic process|ion channel binding|negative regulation of glycolytic process|focal adhesion assembly|positive regulation of skeletal muscle tissue growth|extracellular exosome|negative regulation of calcineurin-NFAT signaling cascade|negative regulation of oxidative phosphorylation|negative regulation of cold-induced thermogenesis|regulation of aerobic respiration|positive regulation of glucose catabolic process to lactate via pyruvate hsa05412 Arrhythmogenic right ventricular cardiomyopathy ACTN4 11065.45091 9882.891471 12248.01035 1.239314464 0.309542304 0.222708964 1 143.5188446 174.8886504 81 actinin alpha 4 "GO:0000977,GO:0001666,GO:0001725,GO:0001882,GO:0002576,GO:0003713,GO:0003723,GO:0003779,GO:0005178,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005925,GO:0015031,GO:0015629,GO:0016604,GO:0030050,GO:0030335,GO:0030374,GO:0031093,GO:0031143,GO:0031490,GO:0032417,GO:0032991,GO:0033209,GO:0035257,GO:0035357,GO:0042803,GO:0042974,GO:0042981,GO:0043005,GO:0044325,GO:0045893,GO:0047485,GO:0048384,GO:0048471,GO:0051015,GO:0051272,GO:0070062,GO:1900025,GO:1901224,GO:1903506,GO:1990904" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|response to hypoxia|stress fiber|nucleoside binding|platelet degranulation|transcription coactivator activity|RNA binding|actin binding|integrin binding|calcium ion binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|cytosol|focal adhesion|protein transport|actin cytoskeleton|nuclear body|vesicle transport along actin filament|positive regulation of cell migration|nuclear receptor coactivator activity|platelet alpha granule lumen|pseudopodium|chromatin DNA binding|positive regulation of sodium:proton antiporter activity|protein-containing complex|tumor necrosis factor-mediated signaling pathway|nuclear hormone receptor binding|peroxisome proliferator activated receptor signaling pathway|protein homodimerization activity|retinoic acid receptor binding|regulation of apoptotic process|neuron projection|ion channel binding|positive regulation of transcription, DNA-templated|protein N-terminus binding|retinoic acid receptor signaling pathway|perinuclear region of cytoplasm|actin filament binding|positive regulation of cellular component movement|extracellular exosome|negative regulation of substrate adhesion-dependent cell spreading|positive regulation of NIK/NF-kappaB signaling|regulation of nucleic acid-templated transcription|ribonucleoprotein complex" "hsa04510,hsa04520,hsa04530,hsa04670,hsa04810,hsa05131,hsa05146,hsa05203,hsa05322" Focal adhesion|Adherens junction|Tight junction|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Shigellosis|Amoebiasis|Viral carcinogenesis|Systemic lupus erythematosus ACTR10 1423.914994 1285.951559 1561.878428 1.214570189 0.280445865 0.241359845 1 43.05449888 51.41766317 55860 actin related protein 10 "GO:0005515,GO:0005576,GO:0005829,GO:0005869,GO:0006888,GO:0007018,GO:0019886,GO:0035578,GO:0043312,GO:0098958,GO:1904115,GO:1904813" protein binding|extracellular region|cytosol|dynactin complex|endoplasmic reticulum to Golgi vesicle-mediated transport|microtubule-based movement|antigen processing and presentation of exogenous peptide antigen via MHC class II|azurophil granule lumen|neutrophil degranulation|retrograde axonal transport of mitochondrion|axon cytoplasm|ficolin-1-rich granule lumen "hsa05014,hsa05016,hsa05022,hsa05132" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection ACTR1A 9251.078884 8565.727496 9936.430273 1.160021759 0.214151866 0.390929278 1 161.5325559 184.2457077 10121 actin related protein 1A "GO:0000086,GO:0002177,GO:0005515,GO:0005524,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0005869,GO:0005875,GO:0006888,GO:0007283,GO:0010389,GO:0015630,GO:0016192,GO:0019886,GO:0030137,GO:0070062,GO:0097711,GO:0099738" G2/M transition of mitotic cell cycle|manchette|protein binding|ATP binding|cytoplasm|centrosome|centriole|cytosol|dynactin complex|microtubule associated complex|endoplasmic reticulum to Golgi vesicle-mediated transport|spermatogenesis|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|COPI-coated vesicle|extracellular exosome|ciliary basal body-plasma membrane docking|cell cortex region "hsa05014,hsa05016,hsa05022,hsa05132" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection ACTR1B 903.8874197 893.7155252 914.0593141 1.022763159 0.0324721 0.900428649 1 19.65222703 19.76323466 10120 actin related protein 1B "GO:0005515,GO:0005524,GO:0005576,GO:0005737,GO:0005813,GO:0005829,GO:0005869,GO:0015630,GO:0016020,GO:0019886,GO:0034774,GO:0043312,GO:0070062,GO:1904813" protein binding|ATP binding|extracellular region|cytoplasm|centrosome|cytosol|dynactin complex|microtubule cytoskeleton|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|secretory granule lumen|neutrophil degranulation|extracellular exosome|ficolin-1-rich granule lumen "hsa05014,hsa05016,hsa05022,hsa05132" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection ACTR2 10918.36717 11042.95295 10793.78139 0.977436147 -0.032925636 0.896929934 1 155.1716964 149.1324259 10097 actin related protein 2 "GO:0005200,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005885,GO:0005925,GO:0007163,GO:0008306,GO:0008356,GO:0010592,GO:0014069,GO:0015629,GO:0016020,GO:0016344,GO:0016482,GO:0030027,GO:0030478,GO:0033206,GO:0034314,GO:0035578,GO:0035861,GO:0035902,GO:0035984,GO:0038096,GO:0043312,GO:0045471,GO:0045944,GO:0048013,GO:0051015,GO:0051653,GO:0060271,GO:0061003,GO:0061024,GO:0061825,GO:0070062,GO:0071346,GO:0071437,GO:1904813,GO:1905168,GO:2001032" structural constituent of cytoskeleton|protein binding|ATP binding|extracellular region|nucleus|cytoplasm|cytosol|Arp2/3 protein complex|focal adhesion|establishment or maintenance of cell polarity|associative learning|asymmetric cell division|positive regulation of lamellipodium assembly|postsynaptic density|actin cytoskeleton|membrane|meiotic chromosome movement towards spindle pole|cytosolic transport|lamellipodium|actin cap|meiotic cytokinesis|Arp2/3 complex-mediated actin nucleation|azurophil granule lumen|site of double-strand break|response to immobilization stress|cellular response to trichostatin A|Fc-gamma receptor signaling pathway involved in phagocytosis|neutrophil degranulation|response to ethanol|positive regulation of transcription by RNA polymerase II|ephrin receptor signaling pathway|actin filament binding|spindle localization|cilium assembly|positive regulation of dendritic spine morphogenesis|membrane organization|podosome core|extracellular exosome|cellular response to interferon-gamma|invadopodium|ficolin-1-rich granule lumen|positive regulation of double-strand break repair via homologous recombination|regulation of double-strand break repair via nonhomologous end joining "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ACTR3 8213.403932 7439.999675 8986.808189 1.207904379 0.272506252 0.270397562 1 69.31897844 82.32957779 10096 actin related protein 3 "GO:0005200,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005885,GO:0005903,GO:0005911,GO:0005925,GO:0007163,GO:0008356,GO:0010592,GO:0015629,GO:0016020,GO:0016344,GO:0030027,GO:0033206,GO:0034314,GO:0035861,GO:0038096,GO:0045944,GO:0048013,GO:0051015,GO:0051653,GO:0060271,GO:0061024,GO:0070062,GO:0070358,GO:0071346" structural constituent of cytoskeleton|protein binding|ATP binding|nucleus|cytoplasm|cytosol|Arp2/3 protein complex|brush border|cell-cell junction|focal adhesion|establishment or maintenance of cell polarity|asymmetric cell division|positive regulation of lamellipodium assembly|actin cytoskeleton|membrane|meiotic chromosome movement towards spindle pole|lamellipodium|meiotic cytokinesis|Arp2/3 complex-mediated actin nucleation|site of double-strand break|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of transcription by RNA polymerase II|ephrin receptor signaling pathway|actin filament binding|spindle localization|cilium assembly|membrane organization|extracellular exosome|actin polymerization-dependent cell motility|cellular response to interferon-gamma "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ACTR3B 92.0275532 107.1626299 76.89247648 0.717530696 -0.478887542 0.323315056 1 0.86731462 0.611911099 57180 actin related protein 3B "GO:0003674,GO:0005524,GO:0005737,GO:0005856,GO:0008150,GO:0042995,GO:0051015,GO:0070062" molecular_function|ATP binding|cytoplasm|cytoskeleton|biological_process|cell projection|actin filament binding|extracellular exosome "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ACTR3C 16.09684705 6.242483296 25.95121081 4.157193473 2.055609892 0.034855668 0.95006405 0.015924946 0.065095261 653857 actin related protein 3C "GO:0003674,GO:0005524,GO:0008150,GO:0051015,GO:0070062" molecular_function|ATP binding|biological_process|actin filament binding|extracellular exosome "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ACTR5 306.5622474 314.2049926 298.9195023 0.951351854 -0.071949079 0.827363549 1 6.583644668 6.158553673 79913 actin related protein 5 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006302,GO:0006310,GO:0006355,GO:0016579,GO:0031011,GO:0043044,GO:0070914" "protein binding|nucleus|nucleoplasm|cytoplasm|double-strand break repair|DNA recombination|regulation of transcription, DNA-templated|protein deubiquitination|Ino80 complex|ATP-dependent chromatin remodeling|UV-damage excision repair" ACTR6 648.9055317 583.6721882 714.1388753 1.223527332 0.29104633 0.262251539 1 17.93293721 21.57427856 64431 actin related protein 6 "GO:0000812,GO:0005515,GO:0005634,GO:0005737,GO:0005856,GO:0031491,GO:0043486" Swr1 complex|protein binding|nucleus|cytoplasm|cytoskeleton|nucleosome binding|histone exchange ACTR8 967.5413649 949.8978749 985.1848549 1.037148183 0.052622034 0.83481217 1 4.279806141 4.36451597 93973 actin related protein 8 "GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005813,GO:0006302,GO:0006310,GO:0006355,GO:0007049,GO:0016579,GO:0031011,GO:0043044,GO:0051301" "protein binding|ATP binding|nucleus|nucleoplasm|centrosome|double-strand break repair|DNA recombination|regulation of transcription, DNA-templated|cell cycle|protein deubiquitination|Ino80 complex|ATP-dependent chromatin remodeling|cell division" ACTRT3 33.22404715 39.53572754 26.91236677 0.680710042 -0.554887701 0.438999823 1 1.262686484 0.845140411 84517 actin related protein T3 "GO:0005634,GO:0005737,GO:0005856" nucleus|cytoplasm|cytoskeleton ACVR1 949.8392376 951.9787026 947.6997726 0.995505225 -0.006499207 0.98381944 1 12.98373465 12.70908703 90 activin A receptor type 1 "GO:0000082,GO:0001525,GO:0001569,GO:0001701,GO:0001702,GO:0001707,GO:0001755,GO:0002526,GO:0003143,GO:0003148,GO:0003181,GO:0003183,GO:0003203,GO:0003274,GO:0003289,GO:0004672,GO:0004674,GO:0004675,GO:0005025,GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0006468,GO:0007179,GO:0007281,GO:0007368,GO:0007507,GO:0009953,GO:0009968,GO:0010862,GO:0016361,GO:0017046,GO:0018107,GO:0030278,GO:0030335,GO:0030501,GO:0030509,GO:0032924,GO:0032926,GO:0042803,GO:0043235,GO:0045177,GO:0045296,GO:0045669,GO:0045893,GO:0045944,GO:0046332,GO:0046872,GO:0048179,GO:0048185,GO:0050431,GO:0050731,GO:0051145,GO:0060037,GO:0060389,GO:0060412,GO:0060923,GO:0061312,GO:0061445,GO:0070724,GO:0071363,GO:0071773,GO:1905007,GO:1990782,GO:2000017,GO:2001237" "G1/S transition of mitotic cell cycle|angiogenesis|branching involved in blood vessel morphogenesis|in utero embryonic development|gastrulation with mouth forming second|mesoderm formation|neural crest cell migration|acute inflammatory response|embryonic heart tube morphogenesis|outflow tract septum morphogenesis|atrioventricular valve morphogenesis|mitral valve morphogenesis|endocardial cushion morphogenesis|endocardial cushion fusion|atrial septum primum morphogenesis|protein kinase activity|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|transforming growth factor beta receptor activity, type I|protein binding|ATP binding|plasma membrane|integral component of plasma membrane|protein phosphorylation|transforming growth factor beta receptor signaling pathway|germ cell development|determination of left/right symmetry|heart development|dorsal/ventral pattern formation|negative regulation of signal transduction|positive regulation of pathway-restricted SMAD protein phosphorylation|activin receptor activity, type I|peptide hormone binding|peptidyl-threonine phosphorylation|regulation of ossification|positive regulation of cell migration|positive regulation of bone mineralization|BMP signaling pathway|activin receptor signaling pathway|negative regulation of activin receptor signaling pathway|protein homodimerization activity|receptor complex|apical part of cell|cadherin binding|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|SMAD binding|metal ion binding|activin receptor complex|activin binding|transforming growth factor beta binding|positive regulation of peptidyl-tyrosine phosphorylation|smooth muscle cell differentiation|pharyngeal system development|pathway-restricted SMAD protein phosphorylation|ventricular septum morphogenesis|cardiac muscle cell fate commitment|BMP signaling pathway involved in heart development|endocardial cushion cell fate commitment|BMP receptor complex|cellular response to growth factor stimulus|cellular response to BMP stimulus|positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|protein tyrosine kinase binding|positive regulation of determination of dorsal identity|negative regulation of extrinsic apoptotic signaling pathway" "hsa04060,hsa04350,hsa04550,hsa05418" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells|Fluid shear stress and atherosclerosis ACVR1B 640.1796719 770.946687 509.4126567 0.660762495 -0.597796293 0.02145704 0.822216713 7.582751151 4.926555354 91 activin A receptor type 1B "GO:0000082,GO:0001701,GO:0001942,GO:0004674,GO:0004675,GO:0005515,GO:0005524,GO:0005829,GO:0005886,GO:0005887,GO:0006355,GO:0006468,GO:0007165,GO:0007178,GO:0007399,GO:0007417,GO:0009986,GO:0010629,GO:0010862,GO:0016361,GO:0017002,GO:0018107,GO:0019838,GO:0030308,GO:0031625,GO:0032924,GO:0032927,GO:0034711,GO:0038092,GO:0043235,GO:0045648,GO:0045944,GO:0046332,GO:0046545,GO:0046777,GO:0046872,GO:0048179,GO:0048185,GO:0071363,GO:0097191,GO:1901165" "G1/S transition of mitotic cell cycle|in utero embryonic development|hair follicle development|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|protein binding|ATP binding|cytosol|plasma membrane|integral component of plasma membrane|regulation of transcription, DNA-templated|protein phosphorylation|signal transduction|transmembrane receptor protein serine/threonine kinase signaling pathway|nervous system development|central nervous system development|cell surface|negative regulation of gene expression|positive regulation of pathway-restricted SMAD protein phosphorylation|activin receptor activity, type I|activin-activated receptor activity|peptidyl-threonine phosphorylation|growth factor binding|negative regulation of cell growth|ubiquitin protein ligase binding|activin receptor signaling pathway|positive regulation of activin receptor signaling pathway|inhibin binding|nodal signaling pathway|receptor complex|positive regulation of erythrocyte differentiation|positive regulation of transcription by RNA polymerase II|SMAD binding|development of primary female sexual characteristics|protein autophosphorylation|metal ion binding|activin receptor complex|activin binding|cellular response to growth factor stimulus|extrinsic apoptotic signaling pathway|positive regulation of trophoblast cell migration" "hsa04060,hsa04350,hsa04550" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells ACVR1C 43.95527852 43.69738307 44.21317398 1.011803702 0.016929423 1 1 0.257571131 0.256250445 130399 activin A receptor type 1C "GO:0001834,GO:0002021,GO:0004674,GO:0005524,GO:0005886,GO:0006468,GO:0007399,GO:0009749,GO:0016361,GO:0019838,GO:0019915,GO:0030154,GO:0030262,GO:0032868,GO:0032924,GO:0038092,GO:0038100,GO:0043065,GO:0043235,GO:0043280,GO:0046676,GO:0046872,GO:0048179,GO:0071363,GO:1901164,GO:1901383" "trophectodermal cell proliferation|response to dietary excess|protein serine/threonine kinase activity|ATP binding|plasma membrane|protein phosphorylation|nervous system development|response to glucose|activin receptor activity, type I|growth factor binding|lipid storage|cell differentiation|apoptotic nuclear changes|response to insulin|activin receptor signaling pathway|nodal signaling pathway|nodal binding|positive regulation of apoptotic process|receptor complex|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of insulin secretion|metal ion binding|activin receptor complex|cellular response to growth factor stimulus|negative regulation of trophoblast cell migration|negative regulation of chorionic trophoblast cell proliferation" "hsa04060,hsa04350,hsa04550" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells ACVR2A 144.2319153 152.9408407 135.5229898 0.886113801 -0.174436102 0.682964228 1 1.510394444 1.315985363 92 activin A receptor type 2A "GO:0001702,GO:0001934,GO:0004674,GO:0004675,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0005887,GO:0006468,GO:0007178,GO:0007283,GO:0007368,GO:0007498,GO:0009952,GO:0009986,GO:0010862,GO:0015026,GO:0017002,GO:0019838,GO:0030165,GO:0030501,GO:0030509,GO:0032924,GO:0032927,GO:0034673,GO:0034711,GO:0042713,GO:0043084,GO:0043235,GO:0043621,GO:0045648,GO:0045669,GO:0045944,GO:0046872,GO:0048179,GO:0048185,GO:0048706,GO:0050999,GO:0060011,GO:0071363,GO:0071773,GO:0098821" gastrulation with mouth forming second|positive regulation of protein phosphorylation|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|plasma membrane|integral component of plasma membrane|protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|spermatogenesis|determination of left/right symmetry|mesoderm development|anterior/posterior pattern specification|cell surface|positive regulation of pathway-restricted SMAD protein phosphorylation|coreceptor activity|activin-activated receptor activity|growth factor binding|PDZ domain binding|positive regulation of bone mineralization|BMP signaling pathway|activin receptor signaling pathway|positive regulation of activin receptor signaling pathway|inhibin-betaglycan-ActRII complex|inhibin binding|sperm ejaculation|penile erection|receptor complex|protein self-association|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|activin receptor complex|activin binding|embryonic skeletal system development|regulation of nitric-oxide synthase activity|Sertoli cell proliferation|cellular response to growth factor stimulus|cellular response to BMP stimulus|BMP receptor activity "hsa04060,hsa04350,hsa04550,hsa05418" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells|Fluid shear stress and atherosclerosis ACVR2B 327.5988524 286.1138177 369.0838871 1.289989732 0.367359582 0.231131108 1 0.844544723 1.071223484 93 activin A receptor type 2B "GO:0000122,GO:0001946,GO:0001974,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0005887,GO:0006355,GO:0006468,GO:0007165,GO:0007178,GO:0009952,GO:0016362,GO:0017002,GO:0019838,GO:0030501,GO:0030509,GO:0032924,GO:0032927,GO:0032991,GO:0043235,GO:0045669,GO:0046872,GO:0048179,GO:0048185,GO:0060836,GO:0060840,GO:0060841,GO:0061298,GO:0071363,GO:0120163" "negative regulation of transcription by RNA polymerase II|lymphangiogenesis|blood vessel remodeling|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|plasma membrane|integral component of plasma membrane|regulation of transcription, DNA-templated|protein phosphorylation|signal transduction|transmembrane receptor protein serine/threonine kinase signaling pathway|anterior/posterior pattern specification|activin receptor activity, type II|activin-activated receptor activity|growth factor binding|positive regulation of bone mineralization|BMP signaling pathway|activin receptor signaling pathway|positive regulation of activin receptor signaling pathway|protein-containing complex|receptor complex|positive regulation of osteoblast differentiation|metal ion binding|activin receptor complex|activin binding|lymphatic endothelial cell differentiation|artery development|venous blood vessel development|retina vasculature development in camera-type eye|cellular response to growth factor stimulus|negative regulation of cold-induced thermogenesis" "hsa04060,hsa04350,hsa04550,hsa05418" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells|Fluid shear stress and atherosclerosis ACVRL1 2.601034707 5.202069413 0 0 #NAME? 0.147074026 1 0.063082228 0 94 activin A receptor like type 1 "GO:0001525,GO:0001936,GO:0001946,GO:0001955,GO:0001974,GO:0002043,GO:0003203,GO:0004674,GO:0004675,GO:0005024,GO:0005025,GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0006275,GO:0006355,GO:0006468,GO:0007162,GO:0007165,GO:0007179,GO:0007507,GO:0008015,GO:0008217,GO:0008285,GO:0009953,GO:0009986,GO:0010596,GO:0010629,GO:0010862,GO:0016361,GO:0019901,GO:0030308,GO:0030336,GO:0030509,GO:0030513,GO:0032332,GO:0032924,GO:0035313,GO:0035912,GO:0043235,GO:0043535,GO:0043537,GO:0045893,GO:0045944,GO:0046332,GO:0046872,GO:0048185,GO:0050431,GO:0051895,GO:0060836,GO:0060840,GO:0060841,GO:0061154,GO:0061298,GO:0070724,GO:0071363,GO:0071560,GO:0071773,GO:0090500,GO:0098821,GO:2000279" "angiogenesis|regulation of endothelial cell proliferation|lymphangiogenesis|blood vessel maturation|blood vessel remodeling|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endocardial cushion morphogenesis|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|transforming growth factor beta-activated receptor activity|transforming growth factor beta receptor activity, type I|protein binding|ATP binding|plasma membrane|integral component of plasma membrane|regulation of DNA replication|regulation of transcription, DNA-templated|protein phosphorylation|negative regulation of cell adhesion|signal transduction|transforming growth factor beta receptor signaling pathway|heart development|blood circulation|regulation of blood pressure|negative regulation of cell population proliferation|dorsal/ventral pattern formation|cell surface|negative regulation of endothelial cell migration|negative regulation of gene expression|positive regulation of pathway-restricted SMAD protein phosphorylation|activin receptor activity, type I|protein kinase binding|negative regulation of cell growth|negative regulation of cell migration|BMP signaling pathway|positive regulation of BMP signaling pathway|positive regulation of chondrocyte differentiation|activin receptor signaling pathway|wound healing, spreading of epidermal cells|dorsal aorta morphogenesis|receptor complex|regulation of blood vessel endothelial cell migration|negative regulation of blood vessel endothelial cell migration|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|SMAD binding|metal ion binding|activin binding|transforming growth factor beta binding|negative regulation of focal adhesion assembly|lymphatic endothelial cell differentiation|artery development|venous blood vessel development|endothelial tube morphogenesis|retina vasculature development in camera-type eye|BMP receptor complex|cellular response to growth factor stimulus|cellular response to transforming growth factor beta stimulus|cellular response to BMP stimulus|endocardial cushion to mesenchymal transition|BMP receptor activity|negative regulation of DNA biosynthetic process" hsa04060 Cytokine-cytokine receptor interaction ACYP1 326.8955919 242.4164347 411.3747492 1.696975495 0.762965732 0.012977267 0.6722126 15.02592285 25.07193794 97 acylphosphatase 1 "GO:0003998,GO:0006796" acylphosphatase activity|phosphate-containing compound metabolic process hsa00620 Pyruvate metabolism ACYP2 55.08279953 58.26317743 51.90242162 0.890827173 -0.16678253 0.799764595 1 0.487061199 0.426626834 98 acylphosphatase 2 "GO:0003998,GO:0005515,GO:0006796,GO:0042802" acylphosphatase activity|protein binding|phosphate-containing compound metabolic process|identical protein binding hsa00620 Pyruvate metabolism ADA 203.5606587 209.1231904 197.9981269 0.946801388 -0.078866274 0.839617357 1 7.460240856 6.945170526 100 adenosine deaminase "GO:0001666,GO:0001821,GO:0001829,GO:0001883,GO:0001889,GO:0001890,GO:0002314,GO:0002636,GO:0002686,GO:0002906,GO:0004000,GO:0005515,GO:0005615,GO:0005764,GO:0005829,GO:0005886,GO:0006154,GO:0006157,GO:0007155,GO:0007568,GO:0008270,GO:0009168,GO:0009897,GO:0009986,GO:0010460,GO:0016020,GO:0030054,GO:0030890,GO:0032261,GO:0032839,GO:0033089,GO:0033197,GO:0033632,GO:0042110,GO:0042323,GO:0042493,GO:0042542,GO:0043025,GO:0043101,GO:0043103,GO:0043278,GO:0045987,GO:0046059,GO:0046061,GO:0046103,GO:0046111,GO:0046638,GO:0048286,GO:0048541,GO:0048566,GO:0050728,GO:0050850,GO:0050862,GO:0060169,GO:0060205,GO:0060407,GO:0070244,GO:0070256" "response to hypoxia|histamine secretion|trophectodermal cell differentiation|purine nucleoside binding|liver development|placenta development|germinal center B cell differentiation|positive regulation of germinal center formation|negative regulation of leukocyte migration|negative regulation of mature B cell apoptotic process|adenosine deaminase activity|protein binding|extracellular space|lysosome|cytosol|plasma membrane|adenosine catabolic process|deoxyadenosine catabolic process|cell adhesion|aging|zinc ion binding|purine ribonucleoside monophosphate biosynthetic process|external side of plasma membrane|cell surface|positive regulation of heart rate|membrane|cell junction|positive regulation of B cell proliferation|purine nucleotide salvage|dendrite cytoplasm|positive regulation of T cell differentiation in thymus|response to vitamin E|regulation of cell-cell adhesion mediated by integrin|T cell activation|negative regulation of circadian sleep/wake cycle, non-REM sleep|response to drug|response to hydrogen peroxide|neuronal cell body|purine-containing compound salvage|hypoxanthine salvage|response to morphine|positive regulation of smooth muscle contraction|dAMP catabolic process|dATP catabolic process|inosine biosynthetic process|xanthine biosynthetic process|positive regulation of alpha-beta T cell differentiation|lung alveolus development|Peyer's patch development|embryonic digestive tract development|negative regulation of inflammatory response|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|negative regulation of adenosine receptor signaling pathway|cytoplasmic vesicle lumen|negative regulation of penile erection|negative regulation of thymocyte apoptotic process|negative regulation of mucus secretion" "hsa00230,hsa05340" Purine metabolism|Primary immunodeficiency ADAL 248.9872393 278.8309205 219.143558 0.785937074 -0.347514286 0.301605108 1 3.788363992 2.927592693 161823 adenosine deaminase like "GO:0004000,GO:0005829,GO:0006154,GO:0009117,GO:0017144,GO:0043101,GO:0046103,GO:0046872" adenosine deaminase activity|cytosol|adenosine catabolic process|nucleotide metabolic process|drug metabolic process|purine-containing compound salvage|inosine biosynthetic process|metal ion binding ADAM10 2273.980867 2469.942557 2078.019177 0.841322876 -0.249268522 0.29171424 1 11.63427138 9.624386747 102 ADAM metallopeptidase domain 10 "GO:0000139,GO:0001701,GO:0004175,GO:0004222,GO:0005102,GO:0005178,GO:0005515,GO:0005634,GO:0005737,GO:0005788,GO:0005794,GO:0005798,GO:0005802,GO:0005886,GO:0005912,GO:0005925,GO:0006468,GO:0006509,GO:0007162,GO:0007219,GO:0007229,GO:0007267,GO:0007283,GO:0008021,GO:0008237,GO:0008284,GO:0008593,GO:0009986,GO:0010629,GO:0010820,GO:0014069,GO:0016020,GO:0016021,GO:0016485,GO:0017124,GO:0019901,GO:0022617,GO:0030136,GO:0030307,GO:0030335,GO:0030424,GO:0034205,GO:0034332,GO:0034612,GO:0035333,GO:0035579,GO:0042117,GO:0042803,GO:0042987,GO:0043025,GO:0043065,GO:0043066,GO:0043197,GO:0043231,GO:0043312,GO:0043687,GO:0044267,GO:0045211,GO:0046872,GO:0046930,GO:0046931,GO:0051089,GO:0061001,GO:0070062,GO:0070821,GO:0071157,GO:0090102,GO:0097038,GO:0097060,GO:0097197,GO:0097327,GO:0098696,GO:0098978,GO:0099173,GO:1901342,GO:1901998,GO:1902945" "Golgi membrane|in utero embryonic development|endopeptidase activity|metalloendopeptidase activity|signaling receptor binding|integrin binding|protein binding|nucleus|cytoplasm|endoplasmic reticulum lumen|Golgi apparatus|Golgi-associated vesicle|trans-Golgi network|plasma membrane|adherens junction|focal adhesion|protein phosphorylation|membrane protein ectodomain proteolysis|negative regulation of cell adhesion|Notch signaling pathway|integrin-mediated signaling pathway|cell-cell signaling|spermatogenesis|synaptic vesicle|metallopeptidase activity|positive regulation of cell population proliferation|regulation of Notch signaling pathway|cell surface|negative regulation of gene expression|positive regulation of T cell chemotaxis|postsynaptic density|membrane|integral component of membrane|protein processing|SH3 domain binding|protein kinase binding|extracellular matrix disassembly|clathrin-coated vesicle|positive regulation of cell growth|positive regulation of cell migration|axon|amyloid-beta formation|adherens junction organization|response to tumor necrosis factor|Notch receptor processing, ligand-dependent|specific granule membrane|monocyte activation|protein homodimerization activity|amyloid precursor protein catabolic process|neuronal cell body|positive regulation of apoptotic process|negative regulation of apoptotic process|dendritic spine|intracellular membrane-bounded organelle|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|postsynaptic membrane|metal ion binding|pore complex|pore complex assembly|constitutive protein ectodomain proteolysis|regulation of dendritic spine morphogenesis|extracellular exosome|tertiary granule membrane|negative regulation of cell cycle arrest|cochlea development|perinuclear endoplasmic reticulum|synaptic membrane|tetraspanin-enriched microdomain|response to antineoplastic agent|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane|glutamatergic synapse|postsynapse organization|regulation of vasculature development|toxin transport|metalloendopeptidase activity involved in amyloid precursor protein catabolic process" "hsa05010,hsa05120" Alzheimer disease|Epithelial cell signaling in Helicobacter pylori infection ADAM11 38.66892077 43.69738307 33.64045846 0.769850643 -0.377349516 0.586791102 1 0.456458998 0.345524962 4185 ADAM metallopeptidase domain 11 "GO:0004222,GO:0005178,GO:0005886,GO:0006508,GO:0007229,GO:0008237,GO:0016021,GO:0062023" metalloendopeptidase activity|integrin binding|plasma membrane|proteolysis|integrin-mediated signaling pathway|metallopeptidase activity|integral component of membrane|collagen-containing extracellular matrix ADAM12 817.8941441 818.8057256 816.9825626 0.997773388 -0.003215904 0.99535462 1 3.985967042 3.910540592 8038 ADAM metallopeptidase domain 12 "GO:0004222,GO:0005515,GO:0005576,GO:0005654,GO:0005886,GO:0006508,GO:0007155,GO:0007520,GO:0008237,GO:0016021,GO:0017124,GO:0030198,GO:0045766,GO:0046872" metalloendopeptidase activity|protein binding|extracellular region|nucleoplasm|plasma membrane|proteolysis|cell adhesion|myoblast fusion|metallopeptidase activity|integral component of membrane|SH3 domain binding|extracellular matrix organization|positive regulation of angiogenesis|metal ion binding ADAM15 2114.124465 2032.968727 2195.280203 1.079839633 0.110817073 0.640408436 1 33.51739404 35.58776277 8751 ADAM metallopeptidase domain 15 "GO:0001525,GO:0001669,GO:0001953,GO:0002418,GO:0004222,GO:0005178,GO:0005515,GO:0005615,GO:0005886,GO:0005912,GO:0006508,GO:0006915,GO:0007160,GO:0007229,GO:0008237,GO:0008584,GO:0009986,GO:0016021,GO:0017124,GO:0022617,GO:0030198,GO:0030308,GO:0030336,GO:0030574,GO:0031514,GO:0042246,GO:0045087,GO:0046872,GO:0060317,GO:0070062,GO:1900121,GO:1904628,GO:1990910" angiogenesis|acrosomal vesicle|negative regulation of cell-matrix adhesion|immune response to tumor cell|metalloendopeptidase activity|integrin binding|protein binding|extracellular space|plasma membrane|adherens junction|proteolysis|apoptotic process|cell-matrix adhesion|integrin-mediated signaling pathway|metallopeptidase activity|male gonad development|cell surface|integral component of membrane|SH3 domain binding|extracellular matrix disassembly|extracellular matrix organization|negative regulation of cell growth|negative regulation of cell migration|collagen catabolic process|motile cilium|tissue regeneration|innate immune response|metal ion binding|cardiac epithelial to mesenchymal transition|extracellular exosome|negative regulation of receptor binding|cellular response to phorbol 13-acetate 12-myristate|response to hypobaric hypoxia ADAM17 1227.605207 1469.064402 986.1460108 0.671274867 -0.575024468 0.017451517 0.770503287 11.75255091 7.757177101 6868 ADAM metallopeptidase domain 17 "GO:0001666,GO:0001934,GO:0002446,GO:0002467,GO:0002690,GO:0004175,GO:0004222,GO:0005112,GO:0005138,GO:0005178,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0005911,GO:0005925,GO:0006508,GO:0006509,GO:0007155,GO:0007173,GO:0007219,GO:0007220,GO:0008233,GO:0008237,GO:0008284,GO:0009986,GO:0010820,GO:0015629,GO:0016020,GO:0016324,GO:0016485,GO:0017124,GO:0030165,GO:0030183,GO:0030307,GO:0030335,GO:0030511,GO:0030512,GO:0031293,GO:0032496,GO:0032587,GO:0032722,GO:0033025,GO:0033077,GO:0033209,GO:0033627,GO:0035313,GO:0035624,GO:0042493,GO:0042987,GO:0043536,GO:0045121,GO:0045737,GO:0045741,GO:0046872,GO:0048536,GO:0048870,GO:0050830,GO:0051272,GO:0071403,GO:0120163,GO:1900087,GO:1902945,GO:1903265,GO:1905564" "response to hypoxia|positive regulation of protein phosphorylation|neutrophil mediated immunity|germinal center formation|positive regulation of leukocyte chemotaxis|endopeptidase activity|metalloendopeptidase activity|Notch binding|interleukin-6 receptor binding|integrin binding|protein binding|cytoplasm|cytosol|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|proteolysis|membrane protein ectodomain proteolysis|cell adhesion|epidermal growth factor receptor signaling pathway|Notch signaling pathway|Notch receptor processing|peptidase activity|metallopeptidase activity|positive regulation of cell population proliferation|cell surface|positive regulation of T cell chemotaxis|actin cytoskeleton|membrane|apical plasma membrane|protein processing|SH3 domain binding|PDZ domain binding|B cell differentiation|positive regulation of cell growth|positive regulation of cell migration|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|membrane protein intracellular domain proteolysis|response to lipopolysaccharide|ruffle membrane|positive regulation of chemokine production|regulation of mast cell apoptotic process|T cell differentiation in thymus|tumor necrosis factor-mediated signaling pathway|cell adhesion mediated by integrin|wound healing, spreading of epidermal cells|receptor transactivation|response to drug|amyloid precursor protein catabolic process|positive regulation of blood vessel endothelial cell migration|membrane raft|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of epidermal growth factor-activated receptor activity|metal ion binding|spleen development|cell motility|defense response to Gram-positive bacterium|positive regulation of cellular component movement|cellular response to high density lipoprotein particle stimulus|negative regulation of cold-induced thermogenesis|positive regulation of G1/S transition of mitotic cell cycle|metalloendopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of vascular endothelial cell proliferation" "hsa04330,hsa05010,hsa05120,hsa05171" Notch signaling pathway|Alzheimer disease|Epithelial cell signaling in Helicobacter pylori infection|Coronavirus disease - COVID-19 ADAM19 691.3102503 599.2783964 783.3421041 1.307142238 0.386416138 0.132286594 1 4.92718943 6.332763746 8728 ADAM metallopeptidase domain 19 "GO:0001890,GO:0004222,GO:0005515,GO:0005634,GO:0005794,GO:0005886,GO:0006509,GO:0010628,GO:0016021,GO:0016485,GO:0017124,GO:0030198,GO:0042987,GO:0046872,GO:0062023,GO:1902945,GO:2000049" placenta development|metalloendopeptidase activity|protein binding|nucleus|Golgi apparatus|plasma membrane|membrane protein ectodomain proteolysis|positive regulation of gene expression|integral component of membrane|protein processing|SH3 domain binding|extracellular matrix organization|amyloid precursor protein catabolic process|metal ion binding|collagen-containing extracellular matrix|metalloendopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of cell-cell adhesion mediated by cadherin ADAM20 4.964295633 4.161655531 5.766935736 1.385731158 0.470647391 0.897151737 1 0.016525291 0.022516416 8748 ADAM metallopeptidase domain 20 "GO:0004222,GO:0005886,GO:0006508,GO:0007338,GO:0007339,GO:0008237,GO:0008584,GO:0009897,GO:0016021,GO:0046872,GO:1990913" metalloendopeptidase activity|plasma membrane|proteolysis|single fertilization|binding of sperm to zona pellucida|metallopeptidase activity|male gonad development|external side of plasma membrane|integral component of membrane|metal ion binding|sperm head plasma membrane ADAM21 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.041953137 0.057162946 8747 ADAM metallopeptidase domain 21 "GO:0004222,GO:0005515,GO:0005886,GO:0006508,GO:0007338,GO:0007339,GO:0008237,GO:0008584,GO:0009897,GO:0016021,GO:0046872,GO:1990913" metalloendopeptidase activity|protein binding|plasma membrane|proteolysis|single fertilization|binding of sperm to zona pellucida|metallopeptidase activity|male gonad development|external side of plasma membrane|integral component of membrane|metal ion binding|sperm head plasma membrane ADAM22 359.990077 404.7210003 315.2591536 0.778954275 -0.36038945 0.226674704 1 2.862719144 2.192612503 53616 ADAM metallopeptidase domain 22 "GO:0004222,GO:0005178,GO:0005515,GO:0005886,GO:0006508,GO:0007155,GO:0007162,GO:0007417,GO:0008344,GO:0016021,GO:0022011,GO:0030424,GO:0098978,GO:0099061,GO:0099645" metalloendopeptidase activity|integrin binding|protein binding|plasma membrane|proteolysis|cell adhesion|negative regulation of cell adhesion|central nervous system development|adult locomotory behavior|integral component of membrane|myelination in peripheral nervous system|axon|glutamatergic synapse|integral component of postsynaptic density membrane|neurotransmitter receptor localization to postsynaptic specialization membrane ADAM23 632.1740069 661.7032294 602.6447844 0.910747836 -0.134876432 0.60789232 1 5.496324544 4.922000976 8745 ADAM metallopeptidase domain 23 "GO:0004222,GO:0005178,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0006508,GO:0007155,GO:0007417,GO:0008237,GO:0098978,GO:0099056,GO:1990830" metalloendopeptidase activity|integrin binding|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|proteolysis|cell adhesion|central nervous system development|metallopeptidase activity|glutamatergic synapse|integral component of presynaptic membrane|cellular response to leukemia inhibitory factor ADAM32 10.48842717 10.40413883 10.57271552 1.016202849 0.023188414 1 1 0.189182203 0.189030493 203102 ADAM metallopeptidase domain 32 "GO:0004222,GO:0005515,GO:0006508,GO:0007155,GO:0007339,GO:0016021" metalloendopeptidase activity|protein binding|proteolysis|cell adhesion|binding of sperm to zona pellucida|integral component of membrane ADAM33 21.21965854 14.56579436 27.87352272 1.913628741 0.936310963 0.268523326 1 0.187042751 0.351940904 80332 ADAM metallopeptidase domain 33 "GO:0004222,GO:0006508,GO:0008270,GO:0016021" metalloendopeptidase activity|proteolysis|zinc ion binding|integral component of membrane ADAM8 955.2539287 1031.050158 879.4576997 0.852972761 -0.229428424 0.353322252 1 14.51470639 12.17347579 101 ADAM metallopeptidase domain 8 "GO:0000902,GO:0001525,GO:0002102,GO:0002523,GO:0002675,GO:0002693,GO:0004222,GO:0004252,GO:0005509,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0006508,GO:0006954,GO:0008237,GO:0008270,GO:0009986,GO:0010954,GO:0022407,GO:0022617,GO:0032010,GO:0032127,GO:0033089,GO:0035579,GO:0042581,GO:0043312,GO:0043406,GO:0043524,GO:0043621,GO:0045089,GO:0045780,GO:0045785,GO:0048247,GO:0050714,GO:0050839,GO:0051044,GO:0051092,GO:0051897,GO:0070245,GO:0070820,GO:0070821,GO:0071065,GO:0071133,GO:0071456,GO:0098609,GO:0101003,GO:2000309,GO:2000391,GO:2000415,GO:2000418" cell morphogenesis|angiogenesis|podosome|leukocyte migration involved in inflammatory response|positive regulation of acute inflammatory response|positive regulation of cellular extravasation|metalloendopeptidase activity|serine-type endopeptidase activity|calcium ion binding|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|proteolysis|inflammatory response|metallopeptidase activity|zinc ion binding|cell surface|positive regulation of protein processing|regulation of cell-cell adhesion|extracellular matrix disassembly|phagolysosome|dense core granule membrane|positive regulation of T cell differentiation in thymus|specific granule membrane|specific granule|neutrophil degranulation|positive regulation of MAP kinase activity|negative regulation of neuron apoptotic process|protein self-association|positive regulation of innate immune response|positive regulation of bone resorption|positive regulation of cell adhesion|lymphocyte chemotaxis|positive regulation of protein secretion|cell adhesion molecule binding|positive regulation of membrane protein ectodomain proteolysis|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling|positive regulation of thymocyte apoptotic process|tertiary granule|tertiary granule membrane|alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|alpha9-beta1 integrin-ADAM8 complex|cellular response to hypoxia|cell-cell adhesion|ficolin-1-rich granule membrane|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production|positive regulation of neutrophil extravasation|positive regulation of fibronectin-dependent thymocyte migration|positive regulation of eosinophil migration ADAM9 5659.373323 6045.845072 5272.901575 0.872152943 -0.197346942 0.41376013 1 73.41425249 62.95702689 8754 ADAM metallopeptidase domain 9 "GO:0000186,GO:0004222,GO:0005080,GO:0005178,GO:0005515,GO:0005518,GO:0005615,GO:0005925,GO:0006509,GO:0007155,GO:0007160,GO:0007179,GO:0007229,GO:0008237,GO:0009986,GO:0010042,GO:0016021,GO:0016477,GO:0017124,GO:0030216,GO:0030335,GO:0031233,GO:0031293,GO:0033627,GO:0033630,GO:0033631,GO:0034241,GO:0034612,GO:0042117,GO:0042542,GO:0043236,GO:0046872,GO:0050714,GO:0051044,GO:0051384,GO:0051549,GO:0051592,GO:0070062,GO:0071222" activation of MAPKK activity|metalloendopeptidase activity|protein kinase C binding|integrin binding|protein binding|collagen binding|extracellular space|focal adhesion|membrane protein ectodomain proteolysis|cell adhesion|cell-matrix adhesion|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|metallopeptidase activity|cell surface|response to manganese ion|integral component of membrane|cell migration|SH3 domain binding|keratinocyte differentiation|positive regulation of cell migration|intrinsic component of external side of plasma membrane|membrane protein intracellular domain proteolysis|cell adhesion mediated by integrin|positive regulation of cell adhesion mediated by integrin|cell-cell adhesion mediated by integrin|positive regulation of macrophage fusion|response to tumor necrosis factor|monocyte activation|response to hydrogen peroxide|laminin binding|metal ion binding|positive regulation of protein secretion|positive regulation of membrane protein ectodomain proteolysis|response to glucocorticoid|positive regulation of keratinocyte migration|response to calcium ion|extracellular exosome|cellular response to lipopolysaccharide ADAMTS1 2745.148502 1970.543894 3519.753111 1.786183562 0.83688035 0.000434062 0.111996241 20.29023845 35.63562809 9510 ADAM metallopeptidase with thrombospondin type 1 motif 1 "GO:0001542,GO:0001822,GO:0004222,GO:0005515,GO:0005604,GO:0006508,GO:0007229,GO:0008201,GO:0008237,GO:0008270,GO:0008285,GO:0016525,GO:0030198,GO:0031012,GO:0031410,GO:0060347,GO:0062023,GO:1900087,GO:1904707,GO:1904754" ovulation from ovarian follicle|kidney development|metalloendopeptidase activity|protein binding|basement membrane|proteolysis|integrin-mediated signaling pathway|heparin binding|metallopeptidase activity|zinc ion binding|negative regulation of cell population proliferation|negative regulation of angiogenesis|extracellular matrix organization|extracellular matrix|cytoplasmic vesicle|heart trabecula formation|collagen-containing extracellular matrix|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of vascular associated smooth muscle cell migration ADAMTS10 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.039268017 0.03566957 81794 ADAM metallopeptidase with thrombospondin type 1 motif 10 "GO:0001527,GO:0003674,GO:0004222,GO:0005515,GO:0006508,GO:0008150,GO:0030198,GO:0031012,GO:0046872,GO:0062023" microfibril|molecular_function|metalloendopeptidase activity|protein binding|proteolysis|biological_process|extracellular matrix organization|extracellular matrix|metal ion binding|collagen-containing extracellular matrix ADAMTS12 3304.113184 3927.562407 2680.663961 0.682526128 -0.55104382 0.020318114 0.810058917 22.78087024 15.28835541 81792 ADAM metallopeptidase with thrombospondin type 1 motif 12 "GO:0004222,GO:0005515,GO:0007160,GO:0016477,GO:0030167,GO:0030198,GO:0031012,GO:0032331,GO:0046872,GO:0050727,GO:0051603,GO:0071347,GO:0071356,GO:0071773,GO:1901509,GO:1902203,GO:1902548,GO:2001113" metalloendopeptidase activity|protein binding|cell-matrix adhesion|cell migration|proteoglycan catabolic process|extracellular matrix organization|extracellular matrix|negative regulation of chondrocyte differentiation|metal ion binding|regulation of inflammatory response|proteolysis involved in cellular protein catabolic process|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to BMP stimulus|regulation of endothelial tube morphogenesis|negative regulation of hepatocyte growth factor receptor signaling pathway|negative regulation of cellular response to vascular endothelial growth factor stimulus|negative regulation of cellular response to hepatocyte growth factor stimulus ADAMTS13 20.37235906 30.1720026 10.57271552 0.350414775 -1.512864486 0.076722806 1 0.269583848 0.0928854 11093 ADAM metallopeptidase with thrombospondin type 1 motif 13 "GO:0004222,GO:0005178,GO:0005509,GO:0005515,GO:0005615,GO:0005788,GO:0006508,GO:0007160,GO:0007229,GO:0008237,GO:0008270,GO:0009100,GO:0009636,GO:0009986,GO:0014075,GO:0016485,GO:0030168,GO:0030198,GO:0031012,GO:0035864,GO:0043171,GO:0071222,GO:0071346,GO:0071353,GO:0071356" metalloendopeptidase activity|integrin binding|calcium ion binding|protein binding|extracellular space|endoplasmic reticulum lumen|proteolysis|cell-matrix adhesion|integrin-mediated signaling pathway|metallopeptidase activity|zinc ion binding|glycoprotein metabolic process|response to toxic substance|cell surface|response to amine|protein processing|platelet activation|extracellular matrix organization|extracellular matrix|response to potassium ion|peptide catabolic process|cellular response to lipopolysaccharide|cellular response to interferon-gamma|cellular response to interleukin-4|cellular response to tumor necrosis factor ADAMTS16 121.2484607 142.5367019 99.96021942 0.7012946 -0.511907475 0.243038502 1 1.527801127 1.053509605 170690 ADAM metallopeptidase with thrombospondin type 1 motif 16 "GO:0001658,GO:0003073,GO:0004222,GO:0006508,GO:0030198,GO:0031012,GO:0046872,GO:0048232,GO:1902017" branching involved in ureteric bud morphogenesis|regulation of systemic arterial blood pressure|metalloendopeptidase activity|proteolysis|extracellular matrix organization|extracellular matrix|metal ion binding|male gamete generation|regulation of cilium assembly ADAMTS17 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.00742478 0.006744387 170691 ADAM metallopeptidase with thrombospondin type 1 motif 17 "GO:0004222,GO:0006508,GO:0030198,GO:0031012,GO:0046872" metalloendopeptidase activity|proteolysis|extracellular matrix organization|extracellular matrix|metal ion binding ADAMTS18 99.4393981 99.87973273 98.99906347 0.991182703 -0.012777083 1 1 0.94544125 0.92142383 170692 ADAM metallopeptidase with thrombospondin type 1 motif 18 "GO:0001654,GO:0004222,GO:0006508,GO:0030198,GO:0031012,GO:0046872,GO:0090331" eye development|metalloendopeptidase activity|proteolysis|extracellular matrix organization|extracellular matrix|metal ion binding|negative regulation of platelet aggregation ADAMTS19 14.16950472 18.72744989 9.61155956 0.513233762 -0.962312016 0.340500071 1 0.111222967 0.056128169 171019 ADAM metallopeptidase with thrombospondin type 1 motif 19 "GO:0004222,GO:0006508,GO:0030198,GO:0031012,GO:0046872" metalloendopeptidase activity|proteolysis|extracellular matrix organization|extracellular matrix|metal ion binding ADAMTS2 13.93173094 12.48496659 15.3784953 1.231761029 0.300722389 0.825910327 1 0.091161543 0.110410228 9509 ADAM metallopeptidase with thrombospondin type 1 motif 2 "GO:0004222,GO:0005576,GO:0007283,GO:0008237,GO:0008270,GO:0016485,GO:0030198,GO:0030199,GO:0030324,GO:0030574,GO:0031012,GO:0043588,GO:0062023" metalloendopeptidase activity|extracellular region|spermatogenesis|metallopeptidase activity|zinc ion binding|protein processing|extracellular matrix organization|collagen fibril organization|lung development|collagen catabolic process|extracellular matrix|skin development|collagen-containing extracellular matrix ADAMTS3 229.734552 252.8205735 206.6485305 0.817372288 -0.290934764 0.402344582 1 1.922018425 1.544715963 9508 ADAM metallopeptidase with thrombospondin type 1 motif 3 "GO:0001701,GO:0004175,GO:0004222,GO:0005515,GO:0005576,GO:0005615,GO:0008201,GO:0008270,GO:0010573,GO:0016485,GO:0030198,GO:0030199,GO:0030574,GO:0031012,GO:0032964,GO:0062023,GO:0070062,GO:0097435,GO:1900748" in utero embryonic development|endopeptidase activity|metalloendopeptidase activity|protein binding|extracellular region|extracellular space|heparin binding|zinc ion binding|vascular endothelial growth factor production|protein processing|extracellular matrix organization|collagen fibril organization|collagen catabolic process|extracellular matrix|collagen biosynthetic process|collagen-containing extracellular matrix|extracellular exosome|supramolecular fiber organization|positive regulation of vascular endothelial growth factor signaling pathway ADAMTS5 15.93330078 14.56579436 17.30080721 1.187769564 0.248254969 0.853385722 1 0.078338171 0.091490668 11096 ADAM metallopeptidase with thrombospondin type 1 motif 5 "GO:0004222,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0006508,GO:0008201,GO:0008233,GO:0008237,GO:0008270,GO:0022617,GO:0030198,GO:0031012,GO:0042742,GO:0044691,GO:0050840,GO:0062023,GO:0120163" metalloendopeptidase activity|integrin binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|proteolysis|heparin binding|peptidase activity|metallopeptidase activity|zinc ion binding|extracellular matrix disassembly|extracellular matrix organization|extracellular matrix|defense response to bacterium|tooth eruption|extracellular matrix binding|collagen-containing extracellular matrix|negative regulation of cold-induced thermogenesis ADAMTS6 1227.146593 1116.364096 1337.929091 1.19847019 0.261194025 0.280155908 1 4.335174272 5.108636188 11174 ADAM metallopeptidase with thrombospondin type 1 motif 6 "GO:0001822,GO:0003279,GO:0004222,GO:0006508,GO:0008237,GO:0030198,GO:0031012,GO:0035904,GO:0046872,GO:0060976" kidney development|cardiac septum development|metalloendopeptidase activity|proteolysis|metallopeptidase activity|extracellular matrix organization|extracellular matrix|aorta development|metal ion binding|coronary vasculature development ADAMTS7 190.0201869 219.5273292 160.5130447 0.731175682 -0.451710006 0.223487616 1 2.057564118 1.479266067 11173 ADAM metallopeptidase with thrombospondin type 1 motif 7 "GO:0004222,GO:0005515,GO:0005788,GO:0008237,GO:0030198,GO:0031012,GO:0032331,GO:0046872,GO:0051603,GO:0071347,GO:0071356,GO:0071773" metalloendopeptidase activity|protein binding|endoplasmic reticulum lumen|metallopeptidase activity|extracellular matrix organization|extracellular matrix|negative regulation of chondrocyte differentiation|metal ion binding|proteolysis involved in cellular protein catabolic process|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to BMP stimulus ADAMTS9 88.22758875 95.7180772 80.7371003 0.843488531 -0.245559643 0.628905896 1 0.670028575 0.555704208 56999 ADAM metallopeptidase with thrombospondin type 1 motif 9 "GO:0003179,GO:0003229,GO:0004222,GO:0005783,GO:0006508,GO:0006516,GO:0007275,GO:0008237,GO:0008270,GO:0010596,GO:0015031,GO:0016192,GO:0030198,GO:0031012,GO:0035909,GO:0043231,GO:0062023,GO:0090673,GO:1903671" heart valve morphogenesis|ventricular cardiac muscle tissue development|metalloendopeptidase activity|endoplasmic reticulum|proteolysis|glycoprotein catabolic process|multicellular organism development|metallopeptidase activity|zinc ion binding|negative regulation of endothelial cell migration|protein transport|vesicle-mediated transport|extracellular matrix organization|extracellular matrix|aorta morphogenesis|intracellular membrane-bounded organelle|collagen-containing extracellular matrix|endothelial cell-matrix adhesion|negative regulation of sprouting angiogenesis ADAMTSL1 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.002466571 0.008962156 92949 ADAMTS like 1 "GO:0004222,GO:0005788,GO:0006508,GO:0030198,GO:0031012" metalloendopeptidase activity|endoplasmic reticulum lumen|proteolysis|extracellular matrix organization|extracellular matrix ADAMTSL4 219.4247624 196.6382238 242.2113009 1.231761029 0.300722389 0.395010555 1 1.930504157 2.33812852 54507 ADAMTS like 4 "GO:0002020,GO:0002064,GO:0004222,GO:0005515,GO:0005614,GO:0005788,GO:0006508,GO:0006915,GO:0030198,GO:0031012,GO:0043065,GO:0062023" protease binding|epithelial cell development|metalloendopeptidase activity|protein binding|interstitial matrix|endoplasmic reticulum lumen|proteolysis|apoptotic process|extracellular matrix organization|extracellular matrix|positive regulation of apoptotic process|collagen-containing extracellular matrix ADAMTSL5 256.3298871 244.4972624 268.1625117 1.096791469 0.133289255 0.696571245 1 4.935086811 5.322185888 339366 ADAMTS like 5 "GO:0001527,GO:0004222,GO:0005515,GO:0005576,GO:0006508,GO:0008201,GO:0030198,GO:0031012,GO:0050436" microfibril|metalloendopeptidase activity|protein binding|extracellular region|proteolysis|heparin binding|extracellular matrix organization|extracellular matrix|microfibril binding ADAP1 91.155716 84.27352449 98.03790751 1.163329861 0.218260229 0.666501991 1 1.621313307 1.854560483 11033 ArfGAP with dual PH domains 1 "GO:0005096,GO:0005515,GO:0005547,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007166,GO:0043087,GO:0043231,GO:0043533,GO:0043547,GO:0046872,GO:1902936" "GTPase activator activity|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|cytoplasm|cytosol|plasma membrane|cell surface receptor signaling pathway|regulation of GTPase activity|intracellular membrane-bounded organelle|inositol 1,3,4,5 tetrakisphosphate binding|positive regulation of GTPase activity|metal ion binding|phosphatidylinositol bisphosphate binding" ADAP2 89.90709647 101.9605605 77.85363244 0.763566148 -0.389174951 0.429260539 1 1.884157797 1.414604765 55803 ArfGAP with dual PH domains 2 "GO:0005096,GO:0005515,GO:0005546,GO:0005547,GO:0005737,GO:0005740,GO:0005886,GO:0007507,GO:0030674,GO:0043231,GO:0043325,GO:0043533,GO:0043547,GO:0046872,GO:0048017" "GTPase activator activity|protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|mitochondrial envelope|plasma membrane|heart development|protein-macromolecule adaptor activity|intracellular membrane-bounded organelle|phosphatidylinositol-3,4-bisphosphate binding|inositol 1,3,4,5 tetrakisphosphate binding|positive regulation of GTPase activity|metal ion binding|inositol lipid-mediated signaling" ADAR 5755.402787 6359.009651 5151.795924 0.81015696 -0.303726653 0.208878676 1 48.50895622 38.6422384 103 adenosine deaminase RNA specific "GO:0001649,GO:0002244,GO:0002566,GO:0003677,GO:0003723,GO:0003725,GO:0003726,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006382,GO:0006396,GO:0006397,GO:0008251,GO:0009615,GO:0016020,GO:0016553,GO:0030218,GO:0031054,GO:0035280,GO:0035455,GO:0043066,GO:0044387,GO:0044530,GO:0045070,GO:0045087,GO:0046872,GO:0051607,GO:0060216,GO:0060337,GO:0060339,GO:0061484,GO:0098586,GO:1900369" osteoblast differentiation|hematopoietic progenitor cell differentiation|somatic diversification of immune receptors via somatic mutation|DNA binding|RNA binding|double-stranded RNA binding|double-stranded RNA adenosine deaminase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|adenosine to inosine editing|RNA processing|mRNA processing|tRNA-specific adenosine deaminase activity|response to virus|membrane|base conversion or substitution editing|erythrocyte differentiation|pre-miRNA processing|miRNA loading onto RISC involved in gene silencing by miRNA|response to interferon-alpha|negative regulation of apoptotic process|negative regulation of protein kinase activity by regulation of protein phosphorylation|supraspliceosomal complex|positive regulation of viral genome replication|innate immune response|metal ion binding|defense response to virus|definitive hemopoiesis|type I interferon signaling pathway|negative regulation of type I interferon-mediated signaling pathway|hematopoietic stem cell homeostasis|cellular response to virus|negative regulation of RNA interference "hsa04623,hsa05162,hsa05164,hsa05171" Cytosolic DNA-sensing pathway|Measles|Influenza A|Coronavirus disease - COVID-19 ADARB1 2493.33889 2235.849434 2750.828346 1.230328082 0.299043079 0.205926955 1 9.436391852 11.41558264 104 adenosine deaminase RNA specific B1 "GO:0003723,GO:0003725,GO:0003726,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006382,GO:0006396,GO:0006397,GO:0007274,GO:0008251,GO:0008285,GO:0016553,GO:0021610,GO:0021618,GO:0021965,GO:0030336,GO:0035264,GO:0044387,GO:0045070,GO:0045087,GO:0045202,GO:0046872,GO:0050884,GO:0051607,GO:0051726,GO:0060384,GO:0060415,GO:0061744,GO:0097049" RNA binding|double-stranded RNA binding|double-stranded RNA adenosine deaminase activity|mRNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|adenosine to inosine editing|RNA processing|mRNA processing|neuromuscular synaptic transmission|tRNA-specific adenosine deaminase activity|negative regulation of cell population proliferation|base conversion or substitution editing|facial nerve morphogenesis|hypoglossal nerve morphogenesis|spinal cord ventral commissure morphogenesis|negative regulation of cell migration|multicellular organism growth|negative regulation of protein kinase activity by regulation of protein phosphorylation|positive regulation of viral genome replication|innate immune response|synapse|metal ion binding|neuromuscular process controlling posture|defense response to virus|regulation of cell cycle|innervation|muscle tissue morphogenesis|motor behavior|motor neuron apoptotic process ADAT1 1452.386138 1591.83324 1312.939036 0.824796846 -0.277889279 0.245066372 1 14.33325702 11.6241996 23536 adenosine deaminase tRNA specific 1 "GO:0003723,GO:0008033,GO:0008251,GO:0046872" RNA binding|tRNA processing|tRNA-specific adenosine deaminase activity|metal ion binding ADAT2 281.3639869 333.9728563 228.7551175 0.684951226 -0.545926834 0.089958585 1 1.77666642 1.19656617 134637 adenosine deaminase tRNA specific 2 "GO:0002100,GO:0005515,GO:0005654,GO:0006400,GO:0008270,GO:0052717" tRNA wobble adenosine to inosine editing|protein binding|nucleoplasm|tRNA modification|zinc ion binding|tRNA-specific adenosine-34 deaminase activity ADAT3 46.56134365 36.41448589 56.7082014 1.557297872 0.639044923 0.304656139 1 1.215368471 1.861019118 113179 adenosine deaminase tRNA specific 3 "GO:0005515,GO:0005654,GO:0006400,GO:0046872,GO:0052717" protein binding|nucleoplasm|tRNA modification|metal ion binding|tRNA-specific adenosine-34 deaminase activity ADCK1 72.17540108 78.0310412 66.31976096 0.84991511 -0.234609344 0.671999054 1 1.208465831 1.009906353 57143 aarF domain containing kinase 1 "GO:0004674,GO:0005524,GO:0005576,GO:0005743,GO:0006468,GO:0007005,GO:0010637,GO:0032592,GO:0055088,GO:1903852" protein serine/threonine kinase activity|ATP binding|extracellular region|mitochondrial inner membrane|protein phosphorylation|mitochondrion organization|negative regulation of mitochondrial fusion|integral component of mitochondrial membrane|lipid homeostasis|positive regulation of cristae formation ADCK2 881.3354676 806.320759 956.3501762 1.186066668 0.246185105 0.323234798 1 16.39933573 19.12522428 90956 aarF domain containing kinase 2 "GO:0004674,GO:0005515,GO:0005524,GO:0006468,GO:0016021" protein serine/threonine kinase activity|protein binding|ATP binding|protein phosphorylation|integral component of membrane ADCK5 272.3424458 261.1438845 283.541007 1.085765449 0.11871248 0.723918492 1 4.507363893 4.812046522 203054 aarF domain containing kinase 5 "GO:0004674,GO:0005515,GO:0006468,GO:0016021" protein serine/threonine kinase activity|protein binding|protein phosphorylation|integral component of membrane ADCY10 3.562190663 5.202069413 1.922311912 0.369528309 -1.436243205 0.543489417 1 0.032058301 0.011648215 55811 adenylate cyclase 10 "GO:0000287,GO:0003351,GO:0004016,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006171,GO:0007283,GO:0015630,GO:0016324,GO:0030145,GO:0030425,GO:0030426,GO:0031514,GO:0035556,GO:0043025,GO:0043065,GO:0045178,GO:0048471,GO:0051117,GO:0071241,GO:0071890" magnesium ion binding|epithelial cilium movement involved in extracellular fluid movement|adenylate cyclase activity|ATP binding|extracellular region|nucleus|cytoplasm|mitochondrion|cytosol|cAMP biosynthetic process|spermatogenesis|microtubule cytoskeleton|apical plasma membrane|manganese ion binding|dendrite|growth cone|motile cilium|intracellular signal transduction|neuronal cell body|positive regulation of apoptotic process|basal part of cell|perinuclear region of cytoplasm|ATPase binding|cellular response to inorganic substance|bicarbonate binding "hsa00230,hsa04024,hsa04371,hsa04713,hsa04714,hsa04935" "Purine metabolism|cAMP signaling pathway|Apelin signaling pathway|Circadian entrainment|Thermogenesis|Growth hormone synthesis, secretion and action" ADCY3 1398.418594 1449.296539 1347.54065 0.929789463 -0.105024019 0.662828148 1 15.55324604 14.21925495 109 adenylate cyclase 3 "GO:0003091,GO:0004016,GO:0005516,GO:0005524,GO:0005737,GO:0005794,GO:0005886,GO:0005887,GO:0005929,GO:0006171,GO:0007165,GO:0007186,GO:0007189,GO:0007190,GO:0007193,GO:0007338,GO:0007340,GO:0007608,GO:0008355,GO:0016020,GO:0016021,GO:0030317,GO:0034199,GO:0046872,GO:0071377,GO:1904322" renal water homeostasis|adenylate cyclase activity|calmodulin binding|ATP binding|cytoplasm|Golgi apparatus|plasma membrane|integral component of plasma membrane|cilium|cAMP biosynthetic process|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|single fertilization|acrosome reaction|sensory perception of smell|olfactory learning|membrane|integral component of membrane|flagellated sperm motility|activation of protein kinase A activity|metal ion binding|cellular response to glucagon stimulus|cellular response to forskolin "hsa00230,hsa01522,hsa04015,hsa04020,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04723,hsa04724,hsa04725,hsa04727,hsa04740,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa04962,hsa04970,hsa04971,hsa04972,hsa04976,hsa05032,hsa05110,hsa05163,hsa05166,hsa05200,hsa05414" "Purine metabolism|Endocrine resistance|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|GABAergic synapse|Olfactory transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Vasopressin-regulated water reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Morphine addiction|Vibrio cholerae infection|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy" ADCY5 39.63510714 31.21241648 48.0577978 1.539701286 0.622650484 0.348562487 1 0.192505409 0.291440959 111 adenylate cyclase 5 "GO:0001973,GO:0003091,GO:0004016,GO:0005524,GO:0005886,GO:0005887,GO:0005929,GO:0006171,GO:0007186,GO:0007189,GO:0007190,GO:0007191,GO:0007193,GO:0007195,GO:0007204,GO:0007626,GO:0008179,GO:0016021,GO:0034199,GO:0045111,GO:0046872,GO:0050885,GO:0061178,GO:0071377,GO:0097110,GO:1904322" G protein-coupled adenosine receptor signaling pathway|renal water homeostasis|adenylate cyclase activity|ATP binding|plasma membrane|integral component of plasma membrane|cilium|cAMP biosynthetic process|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-activating dopamine receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting dopamine receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|locomotory behavior|adenylate cyclase binding|integral component of membrane|activation of protein kinase A activity|intermediate filament cytoskeleton|metal ion binding|neuromuscular process controlling balance|regulation of insulin secretion involved in cellular response to glucose stimulus|cellular response to glucagon stimulus|scaffold protein binding|cellular response to forskolin "hsa00230,hsa01522,hsa04015,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa04970,hsa04971,hsa04972,hsa04976,hsa05012,hsa05030,hsa05031,hsa05032,hsa05034,hsa05163,hsa05166,hsa05200,hsa05414" "Purine metabolism|Endocrine resistance|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Parkinson disease|Cocaine addiction|Amphetamine addiction|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy" ADCY6 1294.248258 1263.062454 1325.434063 1.049381256 0.069538925 0.775257999 1 9.310403554 9.606672526 112 adenylate cyclase 6 "GO:0003091,GO:0004016,GO:0005080,GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0005929,GO:0006171,GO:0007186,GO:0007189,GO:0007190,GO:0007193,GO:0007212,GO:0010977,GO:0016020,GO:0019901,GO:0031226,GO:0032420,GO:0034199,GO:0035811,GO:0046872,GO:0071377,GO:0071380,GO:0071870,GO:0097746,GO:1904117,GO:1904322" renal water homeostasis|adenylate cyclase activity|protein kinase C binding|protein binding|ATP binding|plasma membrane|integral component of plasma membrane|cilium|cAMP biosynthetic process|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|dopamine receptor signaling pathway|negative regulation of neuron projection development|membrane|protein kinase binding|intrinsic component of plasma membrane|stereocilium|activation of protein kinase A activity|negative regulation of urine volume|metal ion binding|cellular response to glucagon stimulus|cellular response to prostaglandin E stimulus|cellular response to catecholamine stimulus|blood vessel diameter maintenance|cellular response to vasopressin|cellular response to forskolin "hsa00230,hsa01522,hsa04015,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04723,hsa04724,hsa04725,hsa04727,hsa04742,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa04961,hsa04962,hsa04970,hsa04971,hsa04972,hsa04976,hsa05032,hsa05163,hsa05166,hsa05200,hsa05414" "Purine metabolism|Endocrine resistance|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|GABAergic synapse|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Vasopressin-regulated water reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Morphine addiction|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy" ADCY7 1229.29539 1349.416806 1109.173973 0.821965436 -0.282850366 0.241914827 1 10.57968192 8.550614853 113 adenylate cyclase 7 "GO:0002819,GO:0003091,GO:0004016,GO:0005524,GO:0005886,GO:0005887,GO:0006171,GO:0007186,GO:0007189,GO:0007190,GO:0007193,GO:0016021,GO:0034199,GO:0046872,GO:0060135,GO:0071285,GO:0071361,GO:0071377,GO:1900016" regulation of adaptive immune response|renal water homeostasis|adenylate cyclase activity|ATP binding|plasma membrane|integral component of plasma membrane|cAMP biosynthetic process|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|integral component of membrane|activation of protein kinase A activity|metal ion binding|maternal process involved in female pregnancy|cellular response to lithium ion|cellular response to ethanol|cellular response to glucagon stimulus|negative regulation of cytokine production involved in inflammatory response "hsa00230,hsa01522,hsa04015,hsa04020,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04723,hsa04724,hsa04725,hsa04727,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa04970,hsa04971,hsa04972,hsa04976,hsa05032,hsa05163,hsa05166,hsa05200,hsa05414" "Purine metabolism|Endocrine resistance|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|GABAergic synapse|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Morphine addiction|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy" ADCY8 11.64772794 15.60620824 7.689247648 0.492704412 -1.021205706 0.35686789 1 0.158190817 0.076637071 114 adenylate cyclase 8 "GO:0003091,GO:0003779,GO:0004016,GO:0005516,GO:0005524,GO:0005886,GO:0005887,GO:0005901,GO:0005905,GO:0006171,GO:0007165,GO:0007186,GO:0007189,GO:0007190,GO:0007193,GO:0007204,GO:0007611,GO:0007613,GO:0007616,GO:0007626,GO:0008294,GO:0010255,GO:0014069,GO:0015629,GO:0016020,GO:0016323,GO:0016324,GO:0030424,GO:0030425,GO:0030665,GO:0031915,GO:0032793,GO:0032809,GO:0034199,GO:0035774,GO:0038003,GO:0042593,GO:0042803,GO:0044853,GO:0045121,GO:0046872,GO:0046982,GO:0046983,GO:0048786,GO:0051259,GO:0051260,GO:0051480,GO:0051721,GO:0060076,GO:0071277,GO:0071315,GO:0071333,GO:0071377,GO:0080135,GO:0098685,GO:0098686,GO:0098978,GO:0099056,GO:0150076,GO:1900273,GO:1900454,GO:1904322" renal water homeostasis|actin binding|adenylate cyclase activity|calmodulin binding|ATP binding|plasma membrane|integral component of plasma membrane|caveola|clathrin-coated pit|cAMP biosynthetic process|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|learning or memory|memory|long-term memory|locomotory behavior|calcium- and calmodulin-responsive adenylate cyclase activity|glucose mediated signaling pathway|postsynaptic density|actin cytoskeleton|membrane|basolateral plasma membrane|apical plasma membrane|axon|dendrite|clathrin-coated vesicle membrane|positive regulation of synaptic plasticity|positive regulation of CREB transcription factor activity|neuronal cell body membrane|activation of protein kinase A activity|positive regulation of insulin secretion involved in cellular response to glucose stimulus|opioid receptor signaling pathway|glucose homeostasis|protein homodimerization activity|plasma membrane raft|membrane raft|metal ion binding|protein heterodimerization activity|protein dimerization activity|presynaptic active zone|protein complex oligomerization|protein homooligomerization|regulation of cytosolic calcium ion concentration|protein phosphatase 2A binding|excitatory synapse|cellular response to calcium ion|cellular response to morphine|cellular response to glucose stimulus|cellular response to glucagon stimulus|regulation of cellular response to stress|Schaffer collateral - CA1 synapse|hippocampal mossy fiber to CA3 synapse|glutamatergic synapse|integral component of presynaptic membrane|neuroinflammatory response|positive regulation of long-term synaptic potentiation|positive regulation of long-term synaptic depression|cellular response to forskolin "hsa00230,hsa01522,hsa04015,hsa04020,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04720,hsa04723,hsa04724,hsa04725,hsa04727,hsa04742,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa04970,hsa04971,hsa04972,hsa04976,hsa05032,hsa05163,hsa05166,hsa05200,hsa05414" "Purine metabolism|Endocrine resistance|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|GABAergic synapse|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Morphine addiction|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy" ADCY9 714.0502863 716.8451651 711.2554074 0.99220228 -0.011293822 0.970830509 1 4.945922296 4.825237433 115 adenylate cyclase 9 "GO:0001701,GO:0003091,GO:0004016,GO:0005524,GO:0005886,GO:0005887,GO:0006171,GO:0007165,GO:0007186,GO:0007189,GO:0007190,GO:0007193,GO:0016021,GO:0030424,GO:0030425,GO:0034199,GO:0046872,GO:0071377,GO:0071880" in utero embryonic development|renal water homeostasis|adenylate cyclase activity|ATP binding|plasma membrane|integral component of plasma membrane|cAMP biosynthetic process|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|integral component of membrane|axon|dendrite|activation of protein kinase A activity|metal ion binding|cellular response to glucagon stimulus|adenylate cyclase-activating adrenergic receptor signaling pathway "hsa00230,hsa01522,hsa04015,hsa04020,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04723,hsa04724,hsa04725,hsa04727,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa04961,hsa04962,hsa04970,hsa04971,hsa04972,hsa04976,hsa05032,hsa05110,hsa05163,hsa05166,hsa05200,hsa05414" "Purine metabolism|Endocrine resistance|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|GABAergic synapse|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Vasopressin-regulated water reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Morphine addiction|Vibrio cholerae infection|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy" ADD1 4404.639327 4318.758027 4490.520626 1.039771295 0.056266232 0.814528069 1 60.02192145 61.36473971 118 adducin 1 "GO:0000902,GO:0001701,GO:0003723,GO:0003779,GO:0005200,GO:0005515,GO:0005516,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005912,GO:0005925,GO:0006884,GO:0008134,GO:0008290,GO:0014069,GO:0016604,GO:0020027,GO:0030036,GO:0030218,GO:0030507,GO:0032092,GO:0035264,GO:0036498,GO:0042803,GO:0045296,GO:0046982,GO:0048873,GO:0051015,GO:0051016,GO:0051017,GO:0055085,GO:0071277,GO:1903142,GO:1903393" cell morphogenesis|in utero embryonic development|RNA binding|actin binding|structural constituent of cytoskeleton|protein binding|calmodulin binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|plasma membrane|adherens junction|focal adhesion|cell volume homeostasis|transcription factor binding|F-actin capping protein complex|postsynaptic density|nuclear body|hemoglobin metabolic process|actin cytoskeleton organization|erythrocyte differentiation|spectrin binding|positive regulation of protein binding|multicellular organism growth|IRE1-mediated unfolded protein response|protein homodimerization activity|cadherin binding|protein heterodimerization activity|homeostasis of number of cells within a tissue|actin filament binding|barbed-end actin filament capping|actin filament bundle assembly|transmembrane transport|cellular response to calcium ion|positive regulation of establishment of endothelial barrier|positive regulation of adherens junction organization ADD3 1097.941543 941.5745638 1254.308523 1.332139345 0.413745 0.089811989 1 9.484730828 12.42355378 120 adducin 3 "GO:0000794,GO:0005200,GO:0005516,GO:0005829,GO:0005856,GO:0005886,GO:0005903,GO:0005911,GO:0005938,GO:0014069,GO:0016020,GO:0051015,GO:0051016,GO:0055085" condensed nuclear chromosome|structural constituent of cytoskeleton|calmodulin binding|cytosol|cytoskeleton|plasma membrane|brush border|cell-cell junction|cell cortex|postsynaptic density|membrane|actin filament binding|barbed-end actin filament capping|transmembrane transport ADGRA2 83.94201591 96.75849109 71.12554074 0.735083195 -0.444020555 0.377115148 1 0.847361804 0.612458345 25960 adhesion G protein-coupled receptor A2 "GO:0002040,GO:0004930,GO:0005515,GO:0005886,GO:0007166,GO:0007186,GO:0007417,GO:0009986,GO:0010595,GO:0016021,GO:0016055,GO:0030175,GO:0043542,GO:0045765,GO:0050920,GO:0090210,GO:0090263,GO:1900747,GO:1990909" sprouting angiogenesis|G protein-coupled receptor activity|protein binding|plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|central nervous system development|cell surface|positive regulation of endothelial cell migration|integral component of membrane|Wnt signaling pathway|filopodium|endothelial cell migration|regulation of angiogenesis|regulation of chemotaxis|regulation of establishment of blood-brain barrier|positive regulation of canonical Wnt signaling pathway|negative regulation of vascular endothelial growth factor signaling pathway|Wnt signalosome ADGRA3 1137.515671 1223.526726 1051.504616 0.859404698 -0.218590432 0.369215767 1 11.52238797 9.736691188 166647 adhesion G protein-coupled receptor A3 "GO:0004930,GO:0005886,GO:0007166,GO:0007186,GO:0009897,GO:0016021" G protein-coupled receptor activity|plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|external side of plasma membrane|integral component of membrane ADGRB1 31.46528151 31.21241648 31.71814655 1.016202849 0.023188414 1 1 0.259260592 0.259052683 575 adhesion G protein-coupled receptor B1 "GO:0001530,GO:0001786,GO:0001891,GO:0004930,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0005911,GO:0005925,GO:0006910,GO:0007155,GO:0007165,GO:0007166,GO:0007186,GO:0007189,GO:0007409,GO:0007422,GO:0007517,GO:0008285,GO:0010596,GO:0014069,GO:0016021,GO:0016525,GO:0030165,GO:0030425,GO:0031397,GO:0042177,GO:0043197,GO:0043277,GO:0043652,GO:0045087,GO:0048167,GO:0048471,GO:0050829,GO:0051965,GO:1901741,GO:1903428" "lipopolysaccharide binding|phosphatidylserine binding|phagocytic cup|G protein-coupled receptor activity|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|phagocytosis, recognition|cell adhesion|signal transduction|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|axonogenesis|peripheral nervous system development|muscle organ development|negative regulation of cell population proliferation|negative regulation of endothelial cell migration|postsynaptic density|integral component of membrane|negative regulation of angiogenesis|PDZ domain binding|dendrite|negative regulation of protein ubiquitination|negative regulation of protein catabolic process|dendritic spine|apoptotic cell clearance|engulfment of apoptotic cell|innate immune response|regulation of synaptic plasticity|perinuclear region of cytoplasm|defense response to Gram-negative bacterium|positive regulation of synapse assembly|positive regulation of myoblast fusion|positive regulation of reactive oxygen species biosynthetic process" hsa04115 p53 signaling pathway ADGRB2 641.9296054 602.399638 681.4595728 1.13124167 0.177907169 0.495782928 1 5.399556856 6.0059912 576 adhesion G protein-coupled receptor B2 "GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0007166,GO:0007186,GO:0007189,GO:0007422,GO:0016021,GO:0016525,GO:0033173" G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|peripheral nervous system development|integral component of membrane|negative regulation of angiogenesis|calcineurin-NFAT signaling cascade ADGRB3 131.2714011 115.485941 147.0568613 1.273374577 0.348656866 0.417889839 1 1.012031595 1.267130734 577 adhesion G protein-coupled receptor B3 "GO:0004930,GO:0005096,GO:0005515,GO:0005886,GO:0005887,GO:0007166,GO:0007186,GO:0007189,GO:0007520,GO:0016021,GO:0016322,GO:0016525,GO:0043083,GO:0043547,GO:0048814,GO:0051965,GO:0061743,GO:0098794,GO:0099558" G protein-coupled receptor activity|GTPase activator activity|protein binding|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|myoblast fusion|integral component of membrane|neuron remodeling|negative regulation of angiogenesis|synaptic cleft|positive regulation of GTPase activity|regulation of dendrite morphogenesis|positive regulation of synapse assembly|motor learning|postsynapse|maintenance of synapse structure ADGRE1 50.20782266 31.21241648 69.20322883 2.217169852 1.148719296 0.056572508 1 0.487346197 1.062448101 2015 adhesion G protein-coupled receptor E1 "GO:0002250,GO:0004930,GO:0005509,GO:0005887,GO:0007155,GO:0007166,GO:0007186,GO:0007189" adaptive immune response|G protein-coupled receptor activity|calcium ion binding|integral component of plasma membrane|cell adhesion|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway ADGRE5 1780.717819 1947.654788 1613.78085 0.828576429 -0.271293315 0.25269863 1 29.78302476 24.26456756 976 adhesion G protein-coupled receptor E5 "GO:0004888,GO:0004930,GO:0005509,GO:0005515,GO:0005886,GO:0005887,GO:0005925,GO:0006954,GO:0006955,GO:0007155,GO:0007166,GO:0007186,GO:0007189,GO:0007267,GO:0016020,GO:0030667,GO:0043312,GO:0070062" transmembrane signaling receptor activity|G protein-coupled receptor activity|calcium ion binding|protein binding|plasma membrane|integral component of plasma membrane|focal adhesion|inflammatory response|immune response|cell adhesion|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|cell-cell signaling|membrane|secretory granule membrane|neutrophil degranulation|extracellular exosome ADGRF3 3.081612685 5.202069413 0.961155956 0.184764154 -2.436243205 0.338470402 1 0.044278291 0.008044142 165082 adhesion G protein-coupled receptor F3 "GO:0004930,GO:0007166,GO:0007186,GO:0016021" G protein-coupled receptor activity|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|integral component of membrane ADGRF4 32.94161399 44.73779695 21.14543103 0.472652488 -1.081148246 0.123677871 1 0.785386184 0.365002958 221393 adhesion G protein-coupled receptor F4 "GO:0004930,GO:0005515,GO:0007166,GO:0007186,GO:0016021" G protein-coupled receptor activity|protein binding|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|integral component of membrane ADGRG1 1293.845095 1567.903721 1019.786469 0.650413961 -0.620569871 0.010050235 0.610531935 14.65174924 9.370235594 9289 adhesion G protein-coupled receptor G1 "GO:0001525,GO:0004930,GO:0005515,GO:0005518,GO:0005887,GO:0007155,GO:0007166,GO:0007186,GO:0007189,GO:0007266,GO:0007267,GO:0007420,GO:0008201,GO:0008285,GO:0010573,GO:0016021,GO:0016477,GO:0021796,GO:0021801,GO:0021819,GO:0035025,GO:0045121,GO:0045785,GO:0050840,GO:0061484,GO:0070062,GO:0070528,GO:0072520,GO:0097451,GO:2000179,GO:2001223" angiogenesis|G protein-coupled receptor activity|protein binding|collagen binding|integral component of plasma membrane|cell adhesion|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|Rho protein signal transduction|cell-cell signaling|brain development|heparin binding|negative regulation of cell population proliferation|vascular endothelial growth factor production|integral component of membrane|cell migration|cerebral cortex regionalization|cerebral cortex radial glia guided migration|layer formation in cerebral cortex|positive regulation of Rho protein signal transduction|membrane raft|positive regulation of cell adhesion|extracellular matrix binding|hematopoietic stem cell homeostasis|extracellular exosome|protein kinase C signaling|seminiferous tubule development|glial limiting end-foot|positive regulation of neural precursor cell proliferation|negative regulation of neuron migration ADGRG3 10.68657199 15.60620824 5.766935736 0.369528309 -1.436243205 0.20707843 1 0.118004343 0.042876259 222487 adhesion G protein-coupled receptor G3 "GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0007166,GO:0007186,GO:0007189,GO:0016021,GO:0030183,GO:0030334,GO:0032792,GO:0035579,GO:0043312,GO:1901223" G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|integral component of membrane|B cell differentiation|regulation of cell migration|negative regulation of CREB transcription factor activity|specific granule membrane|neutrophil degranulation|negative regulation of NIK/NF-kappaB signaling ADGRG6 1405.588864 1246.415831 1564.761896 1.255409196 0.328157682 0.170640059 1 8.144841693 10.0540058 57211 adhesion G protein-coupled receptor G6 "GO:0004930,GO:0005518,GO:0005737,GO:0005886,GO:0005887,GO:0007166,GO:0007186,GO:0007189,GO:0009986,GO:0014037,GO:0016021,GO:0019933,GO:0022011,GO:0042552,GO:0043236,GO:0050840,GO:0060347" G protein-coupled receptor activity|collagen binding|cytoplasm|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|cell surface|Schwann cell differentiation|integral component of membrane|cAMP-mediated signaling|myelination in peripheral nervous system|myelination|laminin binding|extracellular matrix binding|heart trabecula formation ADGRL1 366.1683936 377.6702394 354.6665478 0.939090537 -0.090663842 0.767186625 1 2.373476984 2.191611988 22859 adhesion G protein-coupled receptor L1 "GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0007157,GO:0007166,GO:0007186,GO:0007189,GO:0014069,GO:0016021,GO:0016524,GO:0030246,GO:0030424,GO:0030426,GO:0035584,GO:0042734,GO:0043005,GO:0045202,GO:0050839,GO:0090129" G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|postsynaptic density|integral component of membrane|latrotoxin receptor activity|carbohydrate binding|axon|growth cone|calcium-mediated signaling using intracellular calcium source|presynaptic membrane|neuron projection|synapse|cell adhesion molecule binding|positive regulation of synapse maturation ADGRL2 594.7631521 676.2690237 513.2572805 0.758954296 -0.397915086 0.130696022 1 3.420321727 2.552429534 23266 adhesion G protein-coupled receptor L2 "GO:0004930,GO:0005887,GO:0007166,GO:0007186,GO:0007189,GO:0007420,GO:0009617,GO:0016021,GO:0016524,GO:0030246,GO:0043005,GO:0050808,GO:0051965,GO:0098978,GO:0099055" G protein-coupled receptor activity|integral component of plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|brain development|response to bacterium|integral component of membrane|latrotoxin receptor activity|carbohydrate binding|neuron projection|synapse organization|positive regulation of synapse assembly|glutamatergic synapse|integral component of postsynaptic membrane ADGRL4 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.047068361 0.028503403 64123 adhesion G protein-coupled receptor L4 "GO:0004930,GO:0005509,GO:0005886,GO:0005887,GO:0007166,GO:0007186,GO:0007189,GO:0016021,GO:0031410,GO:0065003" G protein-coupled receptor activity|calcium ion binding|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|integral component of membrane|cytoplasmic vesicle|protein-containing complex assembly ADGRV1 517.2825004 446.3375557 588.2274451 1.317898164 0.398238895 0.142073929 1 1.228225998 1.591590424 84059 adhesion G protein-coupled receptor V1 "GO:0001917,GO:0001965,GO:0002141,GO:0002142,GO:0004930,GO:0005509,GO:0005515,GO:0005737,GO:0005886,GO:0007166,GO:0007186,GO:0007194,GO:0007399,GO:0007601,GO:0007605,GO:0009986,GO:0010739,GO:0010855,GO:0016020,GO:0016021,GO:0016787,GO:0030501,GO:0031647,GO:0043235,GO:0045184,GO:0045202,GO:0045494,GO:0048496,GO:0048839,GO:0050877,GO:0050910,GO:0050953,GO:0060122,GO:0060171,GO:0070062,GO:0071277,GO:0090037,GO:0097264,GO:0098609,GO:1990075,GO:1990696" photoreceptor inner segment|G-protein alpha-subunit binding|stereocilia ankle link|stereocilia ankle link complex|G protein-coupled receptor activity|calcium ion binding|protein binding|cytoplasm|plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|nervous system development|visual perception|sensory perception of sound|cell surface|positive regulation of protein kinase A signaling|adenylate cyclase inhibitor activity|membrane|integral component of membrane|hydrolase activity|positive regulation of bone mineralization|regulation of protein stability|receptor complex|establishment of protein localization|synapse|photoreceptor cell maintenance|maintenance of animal organ identity|inner ear development|nervous system process|detection of mechanical stimulus involved in sensory perception of sound|sensory perception of light stimulus|inner ear receptor cell stereocilium organization|stereocilium membrane|extracellular exosome|cellular response to calcium ion|positive regulation of protein kinase C signaling|self proteolysis|cell-cell adhesion|periciliary membrane compartment|USH2 complex ADH5 3302.120945 3206.555586 3397.686304 1.059606239 0.083528243 0.725413649 1 64.52789526 67.23001142 128 "alcohol dehydrogenase 5 (class III), chi polypeptide" "GO:0001523,GO:0003016,GO:0004024,GO:0005504,GO:0005739,GO:0005829,GO:0006069,GO:0008270,GO:0009055,GO:0010430,GO:0018119,GO:0018467,GO:0022900,GO:0032496,GO:0042802,GO:0045777,GO:0046294,GO:0051409,GO:0051775,GO:0051903,GO:0070062,GO:0106321,GO:0106322" "retinoid metabolic process|respiratory system process|alcohol dehydrogenase activity, zinc-dependent|fatty acid binding|mitochondrion|cytosol|ethanol oxidation|zinc ion binding|electron transfer activity|fatty acid omega-oxidation|peptidyl-cysteine S-nitrosylation|formaldehyde dehydrogenase activity|electron transport chain|response to lipopolysaccharide|identical protein binding|positive regulation of blood pressure|formaldehyde catabolic process|response to nitrosative stress|response to redox state|S-(hydroxymethyl)glutathione dehydrogenase activity|extracellular exosome|S-(hydroxymethyl)glutathione dehydrogenase NADP activity|S-(hydroxymethyl)glutathione dehydrogenase NAD activity" "hsa00010,hsa00071,hsa00350,hsa00830,hsa00980,hsa00982,hsa05204" Glycolysis / Gluconeogenesis|Fatty acid degradation|Tyrosine metabolism|Retinol metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Chemical carcinogenesis ADHFE1 74.13231154 91.55642167 56.7082014 0.619379836 -0.691103679 0.18436737 1 2.477788008 1.509010938 137872 alcohol dehydrogenase iron containing 1 "GO:0004022,GO:0005739,GO:0005759,GO:0006103,GO:0006539,GO:0046872,GO:0047988,GO:0055114" alcohol dehydrogenase (NAD+) activity|mitochondrion|mitochondrial matrix|2-oxoglutarate metabolic process|glutamate catabolic process via 2-oxoglutarate|metal ion binding|hydroxyacid-oxoacid transhydrogenase activity|oxidation-reduction process ADI1 627.5022052 627.3695712 627.6348393 1.000422826 0.00060988 1 1 6.538090404 6.431402529 55256 acireductone dioxygenase 1 "GO:0005506,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006555,GO:0010309,GO:0016491,GO:0019509,GO:0055114" iron ion binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|methionine metabolic process|acireductone dioxygenase [iron(II)-requiring] activity|oxidoreductase activity|L-methionine salvage from methylthioadenosine|oxidation-reduction process hsa00270 Cysteine and methionine metabolism ADIPOR1 2803.962799 2707.156923 2900.768675 1.071518482 0.099656734 0.674398649 1 61.76827252 65.07831509 51094 adiponectin receptor 1 "GO:0005515,GO:0005886,GO:0009755,GO:0010633,GO:0010719,GO:0010906,GO:0016020,GO:0016021,GO:0019216,GO:0019395,GO:0019901,GO:0030308,GO:0031226,GO:0033210,GO:0033211,GO:0038023,GO:0042304,GO:0042593,GO:0042802,GO:0046426,GO:0046427,GO:0046628,GO:0046872,GO:0055100,GO:0097003,GO:0120162,GO:1901223" protein binding|plasma membrane|hormone-mediated signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial to mesenchymal transition|regulation of glucose metabolic process|membrane|integral component of membrane|regulation of lipid metabolic process|fatty acid oxidation|protein kinase binding|negative regulation of cell growth|intrinsic component of plasma membrane|leptin-mediated signaling pathway|adiponectin-activated signaling pathway|signaling receptor activity|regulation of fatty acid biosynthetic process|glucose homeostasis|identical protein binding|negative regulation of receptor signaling pathway via JAK-STAT|positive regulation of receptor signaling pathway via JAK-STAT|positive regulation of insulin receptor signaling pathway|metal ion binding|adiponectin binding|adipokinetic hormone receptor activity|positive regulation of cold-induced thermogenesis|negative regulation of NIK/NF-kappaB signaling "hsa04152,hsa04211,hsa04920,hsa04932" AMPK signaling pathway|Longevity regulating pathway|Adipocytokine signaling pathway|Non-alcoholic fatty liver disease ADIPOR2 1987.708534 1893.553266 2081.863801 1.099448237 0.136779683 0.564140416 1 23.28466766 25.17190068 79602 adiponectin receptor 2 "GO:0001934,GO:0005515,GO:0005886,GO:0007507,GO:0007565,GO:0007584,GO:0009750,GO:0009755,GO:0010629,GO:0014075,GO:0016021,GO:0019395,GO:0030308,GO:0031226,GO:0032496,GO:0033211,GO:0038023,GO:0042304,GO:0042493,GO:0042593,GO:0045471,GO:0046326,GO:0046872,GO:0055100,GO:0061042,GO:0061871,GO:0071398,GO:0097003,GO:0120162" positive regulation of protein phosphorylation|protein binding|plasma membrane|heart development|female pregnancy|response to nutrient|response to fructose|hormone-mediated signaling pathway|negative regulation of gene expression|response to amine|integral component of membrane|fatty acid oxidation|negative regulation of cell growth|intrinsic component of plasma membrane|response to lipopolysaccharide|adiponectin-activated signaling pathway|signaling receptor activity|regulation of fatty acid biosynthetic process|response to drug|glucose homeostasis|response to ethanol|positive regulation of glucose import|metal ion binding|adiponectin binding|vascular wound healing|negative regulation of hepatic stellate cell migration|cellular response to fatty acid|adipokinetic hormone receptor activity|positive regulation of cold-induced thermogenesis "hsa04152,hsa04211,hsa04920,hsa04932" AMPK signaling pathway|Longevity regulating pathway|Adipocytokine signaling pathway|Non-alcoholic fatty liver disease ADIRF 1007.46455 862.5031087 1152.425991 1.336141261 0.418072542 0.088837757 1 73.41340622 96.44926645 10974 adipogenesis regulatory factor "GO:0003674,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0030154,GO:0045600,GO:0045944,GO:0070062,GO:0071478,GO:0072719,GO:2001023" molecular_function|protein binding|nucleus|nucleoplasm|cytosol|cell differentiation|positive regulation of fat cell differentiation|positive regulation of transcription by RNA polymerase II|extracellular exosome|cellular response to radiation|cellular response to cisplatin|regulation of response to drug ADK 2618.553319 1977.826791 3259.279847 1.647909646 0.720637142 0.002394388 0.313463325 24.23163011 39.26333679 132 adenosine kinase "GO:0003723,GO:0004001,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006166,GO:0006175,GO:0009156,GO:0016310,GO:0043101,GO:0044209,GO:0046872" RNA binding|adenosine kinase activity|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|purine ribonucleoside salvage|dATP biosynthetic process|ribonucleoside monophosphate biosynthetic process|phosphorylation|purine-containing compound salvage|AMP salvage|metal ion binding hsa00230 Purine metabolism ADM 713.3772083 598.2379825 828.5164341 1.384927835 0.469810803 0.065984927 1 21.39870081 29.13974382 133 adrenomedullin "GO:0001570,GO:0001666,GO:0001843,GO:0002026,GO:0002031,GO:0003073,GO:0005102,GO:0005179,GO:0005576,GO:0005615,GO:0005737,GO:0006954,GO:0007165,GO:0007186,GO:0007189,GO:0007204,GO:0007507,GO:0007565,GO:0007568,GO:0008209,GO:0008284,GO:0008285,GO:0009409,GO:0009611,GO:0010460,GO:0031100,GO:0031102,GO:0031623,GO:0031700,GO:0032496,GO:0032868,GO:0035809,GO:0042475,GO:0042594,GO:0043065,GO:0043116,GO:0045766,GO:0045906,GO:0046879,GO:0048589,GO:0051384,GO:0060670,GO:0097084,GO:0097647,GO:1990410,GO:2000184,GO:2001214" vasculogenesis|response to hypoxia|neural tube closure|regulation of the force of heart contraction|G protein-coupled receptor internalization|regulation of systemic arterial blood pressure|signaling receptor binding|hormone activity|extracellular region|extracellular space|cytoplasm|inflammatory response|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|heart development|female pregnancy|aging|androgen metabolic process|positive regulation of cell population proliferation|negative regulation of cell population proliferation|response to cold|response to wounding|positive regulation of heart rate|animal organ regeneration|neuron projection regeneration|receptor internalization|adrenomedullin receptor binding|response to lipopolysaccharide|response to insulin|regulation of urine volume|odontogenesis of dentin-containing tooth|response to starvation|positive regulation of apoptotic process|negative regulation of vascular permeability|positive regulation of angiogenesis|negative regulation of vasoconstriction|hormone secretion|developmental growth|response to glucocorticoid|branching involved in labyrinthine layer morphogenesis|vascular associated smooth muscle cell development|amylin receptor signaling pathway|adrenomedullin receptor signaling pathway|positive regulation of progesterone biosynthetic process|positive regulation of vasculogenesis "hsa04080,hsa04270" Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction ADM2 71.89296792 83.23311061 60.55282523 0.727508858 -0.458963281 0.38845876 1 1.054355124 0.754217104 79924 adrenomedullin 2 "GO:0001525,GO:0005179,GO:0005576,GO:0006468,GO:0007186,GO:0007189,GO:0007586,GO:0007631,GO:0010628,GO:0044877,GO:0045766,GO:0045776" angiogenesis|hormone activity|extracellular region|protein phosphorylation|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|digestion|feeding behavior|positive regulation of gene expression|protein-containing complex binding|positive regulation of angiogenesis|negative regulation of blood pressure ADM5 5.444873611 4.161655531 6.728091692 1.616686351 0.693039812 0.747994079 1 0.281852674 0.448042394 199800 adrenomedullin 5 (putative) "GO:0003674,GO:0005575,GO:0005576,GO:0008150" molecular_function|cellular_component|extracellular region|biological_process ADNP 3137.545625 3150.373237 3124.718013 0.991856449 -0.011796759 0.961735594 1 19.45269345 18.97141582 23394 activity dependent neuroprotector homeobox "GO:0000785,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0010468,GO:0046872,GO:0090575" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|regulation of gene expression|metal ion binding|RNA polymerase II transcription regulator complex" ADNP2 1329.760725 1387.912119 1271.60933 0.916203059 -0.126260715 0.600804348 1 13.5560613 12.2122712 22850 ADNP homeobox 2 "GO:0000785,GO:0000981,GO:0003674,GO:0003677,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0010468,GO:0030182,GO:0030307,GO:0034599,GO:0046872,GO:0060548,GO:0071300" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|DNA binding|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|regulation of gene expression|neuron differentiation|positive regulation of cell growth|cellular response to oxidative stress|metal ion binding|negative regulation of cell death|cellular response to retinoic acid" ADO 1263.709534 1218.324657 1309.094412 1.07450375 0.103670518 0.669327649 1 17.2924861 18.26991595 84890 2-aminoethanethiol dioxygenase "GO:0000098,GO:0005515,GO:0005829,GO:0046872,GO:0047800,GO:0055114" sulfur amino acid catabolic process|protein binding|cytosol|metal ion binding|cysteamine dioxygenase activity|oxidation-reduction process hsa00430 Taurine and hypotaurine metabolism ADORA1 73.93919714 73.86938567 74.00900861 1.001890133 0.002724311 1 1 1.231190927 1.212876787 134 adenosine A1 receptor "GO:0000186,GO:0001609,GO:0001659,GO:0001664,GO:0001666,GO:0001883,GO:0001973,GO:0002087,GO:0002674,GO:0002686,GO:0002793,GO:0003084,GO:0003085,GO:0003093,GO:0005515,GO:0005783,GO:0005886,GO:0005887,GO:0006612,GO:0006909,GO:0006954,GO:0007165,GO:0007186,GO:0007193,GO:0007267,GO:0007399,GO:0008285,GO:0014050,GO:0014069,GO:0016042,GO:0016323,GO:0030673,GO:0031072,GO:0031683,GO:0032229,GO:0032244,GO:0032795,GO:0032900,GO:0035307,GO:0035814,GO:0042323,GO:0043025,GO:0043066,GO:0043195,GO:0043197,GO:0043268,GO:0044305,GO:0045741,GO:0045822,GO:0046888,GO:0046982,GO:0048786,GO:0050890,GO:0050965,GO:0050995,GO:0050996,GO:0051930,GO:0051967,GO:0055089,GO:0060079,GO:0060087,GO:0070256,GO:0070328,GO:0086004,GO:0097190,GO:0099055,GO:0099056,GO:0099509,GO:0099582,GO:1900272,GO:1900453,GO:1901216" "activation of MAPKK activity|G protein-coupled adenosine receptor activity|temperature homeostasis|G protein-coupled receptor binding|response to hypoxia|purine nucleoside binding|G protein-coupled adenosine receptor signaling pathway|regulation of respiratory gaseous exchange by nervous system process|negative regulation of acute inflammatory response|negative regulation of leukocyte migration|positive regulation of peptide secretion|positive regulation of systemic arterial blood pressure|negative regulation of systemic arterial blood pressure|regulation of glomerular filtration|protein binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|protein targeting to membrane|phagocytosis|inflammatory response|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|cell-cell signaling|nervous system development|negative regulation of cell population proliferation|negative regulation of glutamate secretion|postsynaptic density|lipid catabolic process|basolateral plasma membrane|axolemma|heat shock protein binding|G-protein beta/gamma-subunit complex binding|negative regulation of synaptic transmission, GABAergic|positive regulation of nucleoside transport|heterotrimeric G-protein binding|negative regulation of neurotrophin production|positive regulation of protein dephosphorylation|negative regulation of renal sodium excretion|negative regulation of circadian sleep/wake cycle, non-REM sleep|neuronal cell body|negative regulation of apoptotic process|terminal bouton|dendritic spine|positive regulation of potassium ion transport|calyx of Held|positive regulation of epidermal growth factor-activated receptor activity|negative regulation of heart contraction|negative regulation of hormone secretion|protein heterodimerization activity|presynaptic active zone|cognition|detection of temperature stimulus involved in sensory perception of pain|negative regulation of lipid catabolic process|positive regulation of lipid catabolic process|regulation of sensory perception of pain|negative regulation of synaptic transmission, glutamatergic|fatty acid homeostasis|excitatory postsynaptic potential|relaxation of vascular associated smooth muscle|negative regulation of mucus secretion|triglyceride homeostasis|regulation of cardiac muscle cell contraction|apoptotic signaling pathway|integral component of postsynaptic membrane|integral component of presynaptic membrane|regulation of presynaptic cytosolic calcium ion concentration|neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration|negative regulation of long-term synaptic potentiation|negative regulation of long-term synaptic depression|positive regulation of neuron death" "hsa04022,hsa04024,hsa04071,hsa04080,hsa04923,hsa04924,hsa05032" cGMP-PKG signaling pathway|cAMP signaling pathway|Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction|Regulation of lipolysis in adipocytes|Renin secretion|Morphine addiction ADORA2A 58.56573226 61.38441908 55.74704545 0.908162793 -0.138977164 0.833197961 1 1.183516483 1.056839883 135 adenosine A2a receptor "GO:0000139,GO:0001609,GO:0001973,GO:0005515,GO:0005882,GO:0005886,GO:0005887,GO:0006355,GO:0006469,GO:0006909,GO:0006915,GO:0006954,GO:0006968,GO:0007186,GO:0007188,GO:0007189,GO:0007205,GO:0007267,GO:0007271,GO:0007417,GO:0007596,GO:0007600,GO:0007626,GO:0008015,GO:0008285,GO:0014049,GO:0014057,GO:0014061,GO:0014069,GO:0016020,GO:0019899,GO:0030425,GO:0030673,GO:0031000,GO:0031802,GO:0035249,GO:0035810,GO:0035815,GO:0040013,GO:0042311,GO:0042493,GO:0042755,GO:0042802,GO:0043025,GO:0043116,GO:0043154,GO:0043524,GO:0044267,GO:0044877,GO:0045938,GO:0048143,GO:0048786,GO:0048812,GO:0050714,GO:0051393,GO:0051881,GO:0051899,GO:0051924,GO:0051968,GO:0060079,GO:0060134,GO:0098978,GO:0099055,GO:0099056,GO:1900273,GO:2000300" "Golgi membrane|G protein-coupled adenosine receptor activity|G protein-coupled adenosine receptor signaling pathway|protein binding|intermediate filament|plasma membrane|integral component of plasma membrane|regulation of transcription, DNA-templated|negative regulation of protein kinase activity|phagocytosis|apoptotic process|inflammatory response|cellular defense response|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|protein kinase C-activating G protein-coupled receptor signaling pathway|cell-cell signaling|synaptic transmission, cholinergic|central nervous system development|blood coagulation|sensory perception|locomotory behavior|blood circulation|negative regulation of cell population proliferation|positive regulation of glutamate secretion|positive regulation of acetylcholine secretion, neurotransmission|regulation of norepinephrine secretion|postsynaptic density|membrane|enzyme binding|dendrite|axolemma|response to caffeine|type 5 metabotropic glutamate receptor binding|synaptic transmission, glutamatergic|positive regulation of urine volume|positive regulation of renal sodium excretion|negative regulation of locomotion|vasodilation|response to drug|eating behavior|identical protein binding|neuronal cell body|negative regulation of vascular permeability|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of neuron apoptotic process|cellular protein metabolic process|protein-containing complex binding|positive regulation of circadian sleep/wake cycle, sleep|astrocyte activation|presynaptic active zone|neuron projection morphogenesis|positive regulation of protein secretion|alpha-actinin binding|regulation of mitochondrial membrane potential|membrane depolarization|regulation of calcium ion transport|positive regulation of synaptic transmission, glutamatergic|excitatory postsynaptic potential|prepulse inhibition|glutamatergic synapse|integral component of postsynaptic membrane|integral component of presynaptic membrane|positive regulation of long-term synaptic potentiation|regulation of synaptic vesicle exocytosis" "hsa04015,hsa04020,hsa04024,hsa04080,hsa04270,hsa05012,hsa05034" Rap1 signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction|Parkinson disease|Alcoholism ADORA2B 1099.789013 1027.928916 1171.64911 1.139815304 0.188800069 0.439766066 1 9.456762109 10.59859085 136 adenosine A2b receptor "GO:0000187,GO:0001609,GO:0001973,GO:0005515,GO:0005886,GO:0005887,GO:0006968,GO:0007186,GO:0007190,GO:0007254,GO:0007588,GO:0044267" activation of MAPK activity|G protein-coupled adenosine receptor activity|G protein-coupled adenosine receptor signaling pathway|protein binding|plasma membrane|integral component of plasma membrane|cellular defense response|G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|JNK cascade|excretion|cellular protein metabolic process "hsa04015,hsa04020,hsa04080,hsa04270,hsa05034" Rap1 signaling pathway|Calcium signaling pathway|Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction|Alcoholism ADPGK 1148.817413 1103.879129 1193.755697 1.081418849 0.112925407 0.644189821 1 11.27718229 11.9912847 83440 ADP dependent glucokinase "GO:0005576,GO:0005783,GO:0005789,GO:0006006,GO:0016020,GO:0043843,GO:0046872,GO:0061621" extracellular region|endoplasmic reticulum|endoplasmic reticulum membrane|glucose metabolic process|membrane|ADP-specific glucokinase activity|metal ion binding|canonical glycolysis hsa00010 Glycolysis / Gluconeogenesis ADPRH 42.75131837 49.93986637 35.56277037 0.712111845 -0.489824245 0.451672414 1 0.722471912 0.505871666 141 ADP-ribosylarginine hydrolase "GO:0000287,GO:0003875,GO:0005096,GO:0005515,GO:0005615,GO:0005776,GO:0005829,GO:0006464,GO:0006886,GO:0030955,GO:0051725,GO:0055037,GO:0090630,GO:2000785" magnesium ion binding|ADP-ribosylarginine hydrolase activity|GTPase activator activity|protein binding|extracellular space|autophagosome|cytosol|cellular protein modification process|intracellular protein transport|potassium ion binding|protein de-ADP-ribosylation|recycling endosome|activation of GTPase activity|regulation of autophagosome assembly ADPRHL1 40.99758315 29.13158871 52.86357758 1.814647944 0.859689682 0.185432195 1 0.722108383 1.288445183 113622 ADP-ribosylhydrolase like 1 "GO:0000287,GO:0003875,GO:0051725" magnesium ion binding|ADP-ribosylarginine hydrolase activity|protein de-ADP-ribosylation ADPRM 192.0714466 197.6786377 186.4642555 0.94326963 -0.084257876 0.832269217 1 6.877278733 6.378574862 56985 "ADP-ribose/CDP-alcohol diphosphatase, manganese dependent" "GO:0005829,GO:0008663,GO:0030145,GO:0034656,GO:0047631,GO:0047734" "cytosol|2',3'-cyclic-nucleotide 2'-phosphodiesterase activity|manganese ion binding|nucleobase-containing small molecule catabolic process|ADP-ribose diphosphatase activity|CDP-glycerol diphosphatase activity" "hsa00230,hsa00564" Purine metabolism|Glycerophospholipid metabolism ADPRS 498.2028058 487.954111 508.4515007 1.042006798 0.05936469 0.834952159 1 15.70640174 16.09231157 54936 ADP-ribosylserine hydrolase "GO:0000287,GO:0004553,GO:0004649,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0006281,GO:0016604,GO:0061463,GO:0071451,GO:0090734,GO:0140290,GO:0140292" "magnesium ion binding|hydrolase activity, hydrolyzing O-glycosyl compounds|poly(ADP-ribose) glycohydrolase activity|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|DNA repair|nuclear body|O-acetyl-ADP-ribose deacetylase activity|cellular response to superoxide|site of DNA damage|peptidyl-serine ADP-deribosylation|ADP-ribosylserine hydrolase activity" ADRA1D 2.923096831 1.040413883 4.80577978 4.619103859 2.207612985 0.416510993 1 0.018873208 0.085718512 146 adrenoceptor alpha 1D "GO:0001996,GO:0004930,GO:0004937,GO:0005515,GO:0005886,GO:0005887,GO:0007186,GO:0007188,GO:0007200,GO:0007204,GO:0007267,GO:0008284,GO:0042802,GO:0043410,GO:0045907,GO:0071880,GO:0150099" positive regulation of heart rate by epinephrine-norepinephrine|G protein-coupled receptor activity|alpha1-adrenergic receptor activity|protein binding|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|cell-cell signaling|positive regulation of cell population proliferation|identical protein binding|positive regulation of MAPK cascade|positive regulation of vasoconstriction|adenylate cyclase-activating adrenergic receptor signaling pathway|neuron-glial cell signaling "hsa04020,hsa04022,hsa04080,hsa04261,hsa04270,hsa04970" Calcium signaling pathway|cGMP-PKG signaling pathway|Neuroactive ligand-receptor interaction|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Salivary secretion ADRB1 5.603389465 8.323311061 2.883467868 0.346432789 -1.529352609 0.352439314 1 0.146166441 0.049789509 153 adrenoceptor beta 1 "GO:0001996,GO:0001997,GO:0002024,GO:0002025,GO:0004930,GO:0004939,GO:0004940,GO:0005085,GO:0005515,GO:0005769,GO:0005886,GO:0005887,GO:0007186,GO:0007190,GO:0009409,GO:0030165,GO:0031649,GO:0031694,GO:0040015,GO:0042596,GO:0043547,GO:0045187,GO:0046982,GO:0050873,GO:0060078,GO:0071880,GO:0098685,GO:0099579,GO:0120162" "positive regulation of heart rate by epinephrine-norepinephrine|positive regulation of the force of heart contraction by epinephrine-norepinephrine|diet induced thermogenesis|norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure|G protein-coupled receptor activity|beta-adrenergic receptor activity|beta1-adrenergic receptor activity|guanyl-nucleotide exchange factor activity|protein binding|early endosome|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|response to cold|PDZ domain binding|heat generation|alpha-2A adrenergic receptor binding|negative regulation of multicellular organism growth|fear response|positive regulation of GTPase activity|regulation of circadian sleep/wake cycle, sleep|protein heterodimerization activity|brown fat cell differentiation|regulation of postsynaptic membrane potential|adenylate cyclase-activating adrenergic receptor signaling pathway|Schaffer collateral - CA1 synapse|G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential|positive regulation of cold-induced thermogenesis" "hsa04020,hsa04022,hsa04024,hsa04080,hsa04261,hsa04540,hsa04923,hsa04924,hsa04970,hsa05414" Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Adrenergic signaling in cardiomyocytes|Gap junction|Regulation of lipolysis in adipocytes|Renin secretion|Salivary secretion|Dilated cardiomyopathy ADRB2 570.2693809 537.8939773 602.6447844 1.120378383 0.163986053 0.539988039 1 14.26051315 15.70981434 154 adrenoceptor beta 2 "GO:0001540,GO:0002024,GO:0002025,GO:0002028,GO:0002032,GO:0004930,GO:0004941,GO:0005515,GO:0005634,GO:0005764,GO:0005768,GO:0005769,GO:0005794,GO:0005886,GO:0005887,GO:0006898,GO:0007166,GO:0007171,GO:0007186,GO:0007188,GO:0007190,GO:0008179,GO:0008333,GO:0009409,GO:0010008,GO:0010739,GO:0015459,GO:0016020,GO:0016324,GO:0016579,GO:0030501,GO:0030665,GO:0031649,GO:0040015,GO:0042802,GO:0042803,GO:0043235,GO:0043410,GO:0044877,GO:0045453,GO:0045944,GO:0045986,GO:0050873,GO:0051380,GO:0061024,GO:0061885,GO:0071875,GO:0071880,GO:0071902,GO:0120162,GO:1901098,GO:1904504,GO:1904646,GO:1990911,GO:2000481,GO:2000969" amyloid-beta binding|diet induced thermogenesis|norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure|regulation of sodium ion transport|desensitization of G protein-coupled receptor signaling pathway by arrestin|G protein-coupled receptor activity|beta2-adrenergic receptor activity|protein binding|nucleus|lysosome|endosome|early endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|receptor-mediated endocytosis|cell surface receptor signaling pathway|activation of transmembrane receptor protein tyrosine kinase activity|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase binding|endosome to lysosome transport|response to cold|endosome membrane|positive regulation of protein kinase A signaling|potassium channel regulator activity|membrane|apical plasma membrane|protein deubiquitination|positive regulation of bone mineralization|clathrin-coated vesicle membrane|heat generation|negative regulation of multicellular organism growth|identical protein binding|protein homodimerization activity|receptor complex|positive regulation of MAPK cascade|protein-containing complex binding|bone resorption|positive regulation of transcription by RNA polymerase II|negative regulation of smooth muscle contraction|brown fat cell differentiation|norepinephrine binding|membrane organization|positive regulation of mini excitatory postsynaptic potential|adrenergic receptor signaling pathway|adenylate cyclase-activating adrenergic receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of cold-induced thermogenesis|positive regulation of autophagosome maturation|positive regulation of lipophagy|cellular response to amyloid-beta|response to psychosocial stress|positive regulation of cAMP-dependent protein kinase activity|positive regulation of AMPA receptor activity "hsa04020,hsa04022,hsa04024,hsa04080,hsa04261,hsa04923,hsa04924,hsa04970" Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Adrenergic signaling in cardiomyocytes|Regulation of lipolysis in adipocytes|Renin secretion|Salivary secretion ADRM1 2933.539601 2853.85528 3013.223922 1.055843281 0.078395711 0.741437303 1 65.19906299 67.68804852 11047 adhesion regulating molecule 1 "GO:0000502,GO:0002020,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006368,GO:0006511,GO:0008541,GO:0010950,GO:0016579,GO:0043130,GO:0043248,GO:0061133,GO:0070628" "proteasome complex|protease binding|protein binding|nucleoplasm|cytosol|plasma membrane|transcription elongation from RNA polymerase II promoter|ubiquitin-dependent protein catabolic process|proteasome regulatory particle, lid subcomplex|positive regulation of endopeptidase activity|protein deubiquitination|ubiquitin binding|proteasome assembly|endopeptidase activator activity|proteasome binding" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection ADSL 1468.240795 1503.39806 1433.08353 0.953229599 -0.069104345 0.774609707 1 19.98345986 18.73006914 158 adenylosuccinate lyase "GO:0004018,GO:0005829,GO:0006164,GO:0006167,GO:0006189,GO:0009168,GO:0032991,GO:0042802,GO:0044208,GO:0070626" "N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity|cytosol|purine nucleotide biosynthetic process|AMP biosynthetic process|'de novo' IMP biosynthetic process|purine ribonucleoside monophosphate biosynthetic process|protein-containing complex|identical protein binding|'de novo' AMP biosynthetic process|(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity" "hsa00230,hsa00250" "Purine metabolism|Alanine, aspartate and glutamate metabolism" ADSS1 42.99915299 31.21241648 54.78588949 1.755259466 0.811684309 0.203286373 1 0.737057213 1.272077887 122622 adenylosuccinate synthase 1 "GO:0000287,GO:0002376,GO:0003924,GO:0004019,GO:0005525,GO:0005737,GO:0005829,GO:0006167,GO:0006531,GO:0006541,GO:0009168,GO:0014850,GO:0035690,GO:0042301,GO:0042594,GO:0042802,GO:0044208,GO:0046040,GO:0051015,GO:0071257" magnesium ion binding|immune system process|GTPase activity|adenylosuccinate synthase activity|GTP binding|cytoplasm|cytosol|AMP biosynthetic process|aspartate metabolic process|glutamine metabolic process|purine ribonucleoside monophosphate biosynthetic process|response to muscle activity|cellular response to drug|phosphate ion binding|response to starvation|identical protein binding|'de novo' AMP biosynthetic process|IMP metabolic process|actin filament binding|cellular response to electrical stimulus "hsa00230,hsa00250" "Purine metabolism|Alanine, aspartate and glutamate metabolism" ADSS2 1101.328898 1181.910171 1020.747625 0.863642306 -0.211494179 0.386320165 1 16.9196281 14.36798612 159 adenylosuccinate synthase 2 "GO:0000287,GO:0002376,GO:0004019,GO:0005515,GO:0005525,GO:0005737,GO:0005739,GO:0005829,GO:0006167,GO:0006531,GO:0009168,GO:0014074,GO:0042301,GO:0044208,GO:0046040,GO:0060359,GO:0070062,GO:0071257" magnesium ion binding|immune system process|adenylosuccinate synthase activity|protein binding|GTP binding|cytoplasm|mitochondrion|cytosol|AMP biosynthetic process|aspartate metabolic process|purine ribonucleoside monophosphate biosynthetic process|response to purine-containing compound|phosphate ion binding|'de novo' AMP biosynthetic process|IMP metabolic process|response to ammonium ion|extracellular exosome|cellular response to electrical stimulus "hsa00230,hsa00250" "Purine metabolism|Alanine, aspartate and glutamate metabolism" ADTRP 895.9257997 873.9476614 917.903938 1.050296235 0.070796295 0.779374829 1 6.582131025 6.797504601 84830 androgen dependent TFPI regulating protein "GO:0001934,GO:0002042,GO:0002686,GO:0003332,GO:0005515,GO:0005901,GO:0009986,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0030195,GO:0042758,GO:0043491,GO:0050709,GO:0071383,GO:0140052,GO:1903038,GO:2000402" positive regulation of protein phosphorylation|cell migration involved in sprouting angiogenesis|negative regulation of leukocyte migration|negative regulation of extracellular matrix constituent secretion|protein binding|caveola|cell surface|positive regulation of gene expression|membrane|integral component of membrane|hydrolase activity|negative regulation of blood coagulation|long-chain fatty acid catabolic process|protein kinase B signaling|negative regulation of protein secretion|cellular response to steroid hormone stimulus|cellular response to oxidised low-density lipoprotein particle stimulus|negative regulation of leukocyte cell-cell adhesion|negative regulation of lymphocyte migration AEBP2 708.3776997 681.4710931 735.2843063 1.078966245 0.109649731 0.671761797 1 6.58259905 6.983553096 121536 AE binding protein 2 "GO:0000122,GO:0000785,GO:0000978,GO:0001227,GO:0005654,GO:0006325,GO:0006357,GO:0035098,GO:0045814,GO:0046872" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleoplasm|chromatin organization|regulation of transcription by RNA polymerase II|ESC/E(Z) complex|negative regulation of gene expression, epigenetic|metal ion binding" other AEN 954.9419274 1010.24188 899.6419748 0.890521362 -0.167277876 0.49952975 1 11.048105 9.673938305 64782 apoptosis enhancing nuclease "GO:0003676,GO:0004527,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0010212,GO:0031965,GO:0042771,GO:0090305" nucleic acid binding|exonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|response to ionizing radiation|nuclear membrane|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|nucleic acid phosphodiester bond hydrolysis AFAP1 3456.811105 3444.810365 3468.811845 1.006967431 0.010017023 0.967667745 1 20.51363512 20.31090286 60312 actin filament associated protein 1 "GO:0003779,GO:0005829,GO:0005925,GO:0009966,GO:0015629,GO:0017124,GO:0042169,GO:0051493" actin binding|cytosol|focal adhesion|regulation of signal transduction|actin cytoskeleton|SH3 domain binding|SH2 domain binding|regulation of cytoskeleton organization AFAP1L1 1291.645995 1459.700677 1123.591313 0.7697409 -0.377555189 0.116798916 1 12.41656716 9.397607091 134265 actin filament associated protein 1 like 1 "GO:0002102,GO:0005515,GO:0005829,GO:0017124,GO:0030054,GO:0071437" podosome|protein binding|cytosol|SH3 domain binding|cell junction|invadopodium AFAP1L2 3.522561699 4.161655531 2.883467868 0.692865579 -0.529352609 0.940314863 1 0.042361226 0.028859492 84632 actin filament associated protein 1 like 2 "GO:0005737,GO:0005829,GO:0005886,GO:0006954,GO:0007346,GO:0017124,GO:0030296,GO:0032675,GO:0032757,GO:0035591,GO:0042169,GO:0045742,GO:0045893,GO:0061098" "cytoplasm|cytosol|plasma membrane|inflammatory response|regulation of mitotic cell cycle|SH3 domain binding|protein tyrosine kinase activator activity|regulation of interleukin-6 production|positive regulation of interleukin-8 production|signaling adaptor activity|SH2 domain binding|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of protein tyrosine kinase activity" AFDN 2023.777034 1831.128433 2216.425635 1.21041517 0.275501974 0.244331564 1 11.51047809 13.6993165 4301 "afadin, adherens junction formation factor" "GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0005911,GO:0005912,GO:0007155,GO:0007165,GO:0007267,GO:0008022,GO:0010628,GO:0016607,GO:0022409,GO:0030054,GO:0030336,GO:0031267,GO:0032880,GO:0034332,GO:0043547,GO:0044291,GO:0044331,GO:0045296,GO:0046930,GO:0046931,GO:0050839,GO:0051015,GO:0061951,GO:0070160,GO:0070830,GO:0090557,GO:2000049" protein binding|nucleoplasm|cytosol|plasma membrane|cell-cell junction|adherens junction|cell adhesion|signal transduction|cell-cell signaling|protein C-terminus binding|positive regulation of gene expression|nuclear speck|positive regulation of cell-cell adhesion|cell junction|negative regulation of cell migration|small GTPase binding|regulation of protein localization|adherens junction organization|positive regulation of GTPase activity|cell-cell contact zone|cell-cell adhesion mediated by cadherin|cadherin binding|pore complex|pore complex assembly|cell adhesion molecule binding|actin filament binding|establishment of protein localization to plasma membrane|tight junction|bicellular tight junction assembly|establishment of endothelial intestinal barrier|positive regulation of cell-cell adhesion mediated by cadherin "hsa04014,hsa04015,hsa04024,hsa04520,hsa04530,hsa04670" Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Adherens junction|Tight junction|Leukocyte transendothelial migration AFF1 1677.137502 1688.591732 1665.683272 0.986433393 -0.019706455 0.936529925 1 8.213364675 7.96636224 4299 AF4/FMR2 family member 1 "GO:0005515,GO:0008023,GO:0010468,GO:0032783" protein binding|transcription elongation factor complex|regulation of gene expression|super elongation complex hsa05202 Transcriptional misregulation in cancer AFF3 97.55168473 113.4051132 81.69825626 0.720410694 -0.473108499 0.319062791 1 0.297377283 0.210648863 3899 AF4/FMR2 family member 3 "GO:0003690,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0010468,GO:0016604,GO:0032783,GO:0034612,GO:0035116" "double-stranded DNA binding|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|regulation of gene expression|nuclear body|super elongation complex|response to tumor necrosis factor|embryonic hindlimb morphogenesis" AFF4 4644.153401 4651.690469 4636.616332 0.996759428 -0.004682749 0.985396212 1 25.84883079 25.33392231 27125 AF4/FMR2 family member 4 "GO:0001650,GO:0005515,GO:0005654,GO:0006366,GO:0006368,GO:0007286,GO:0008023,GO:0010468,GO:0032783,GO:0035327" fibrillar center|protein binding|nucleoplasm|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|spermatid development|transcription elongation factor complex|regulation of gene expression|super elongation complex|transcriptionally active chromatin AF_4 AFG1L 61.17179739 54.1015219 68.24207288 1.261370669 0.334992291 0.562108763 1 0.336045017 0.416784315 246269 AFG1 like ATPase "GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0006123,GO:0007005,GO:0016887,GO:0031966,GO:0035694" "protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial electron transport, cytochrome c to oxygen|mitochondrion organization|ATPase activity|mitochondrial membrane|mitochondrial protein catabolic process" AFG3L2 1783.33959 1801.996845 1764.682335 0.979292689 -0.030187981 0.901048124 1 30.43331002 29.30440318 10939 AFG3 like matrix AAA peptidase subunit 2 "GO:0004176,GO:0004222,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0005745,GO:0006508,GO:0006851,GO:0007409,GO:0007528,GO:0008053,GO:0008237,GO:0008270,GO:0016485,GO:0016540,GO:0021675,GO:0033619,GO:0034982,GO:0036444,GO:0040014,GO:0042407,GO:0042552,GO:0048747,GO:0051082,GO:0051560,GO:0060013,GO:0065003" ATP-dependent peptidase activity|metalloendopeptidase activity|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|m-AAA complex|proteolysis|mitochondrial calcium ion transmembrane transport|axonogenesis|neuromuscular junction development|mitochondrial fusion|metallopeptidase activity|zinc ion binding|protein processing|protein autoprocessing|nerve development|membrane protein proteolysis|mitochondrial protein processing|calcium import into the mitochondrion|regulation of multicellular organism growth|cristae formation|myelination|muscle fiber development|unfolded protein binding|mitochondrial calcium ion homeostasis|righting reflex|protein-containing complex assembly hsa05017 Spinocerebellar ataxia AFMID 376.6171918 387.0339643 366.2004192 0.946171274 -0.079826734 0.793736523 1 9.007977034 8.380466755 125061 arylformamidase "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0016787,GO:0019441,GO:0034354" protein binding|nucleus|cytoplasm|cytosol|hydrolase activity|tryptophan catabolic process to kynurenine|'de novo' NAD biosynthetic process from tryptophan "hsa00380,hsa00630" Tryptophan metabolism|Glyoxylate and dicarboxylate metabolism AFP 2.962725795 2.080827765 3.844623824 1.847641543 0.88568489 0.829811711 1 0.04862082 0.0883306 174 alpha fetoprotein "GO:0005504,GO:0005515,GO:0005615,GO:0005737,GO:0005788,GO:0006810,GO:0008270,GO:0043687,GO:0044267" fatty acid binding|protein binding|extracellular space|cytoplasm|endoplasmic reticulum lumen|transport|zinc ion binding|post-translational protein modification|cellular protein metabolic process hsa04390 Hippo signaling pathway AFTPH 755.2554607 827.1290367 683.3818847 0.82620952 -0.27542041 0.277592578 1 10.53265485 8.556560522 54812 aftiphilin "GO:0005654,GO:0005794,GO:0005829,GO:0015031,GO:0030121,GO:0030276,GO:0032588,GO:0043231,GO:0046907" nucleoplasm|Golgi apparatus|cytosol|protein transport|AP-1 adaptor complex|clathrin binding|trans-Golgi network membrane|intracellular membrane-bounded organelle|intracellular transport AGA 285.1048151 293.3967149 276.8129153 0.943476533 -0.083941461 0.803139492 1 7.686815628 7.130972234 175 aspartylglucosaminidase "GO:0003948,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005764,GO:0005783,GO:0006508,GO:0006517,GO:0008233,GO:0035578,GO:0043312,GO:0043621" N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity|protein binding|extracellular region|extracellular space|cytoplasm|lysosome|endoplasmic reticulum|proteolysis|protein deglycosylation|peptidase activity|azurophil granule lumen|neutrophil degranulation|protein self-association "hsa00511,hsa04142" Other glycan degradation|Lysosome AGAP1 1374.925608 1311.961906 1437.88931 1.09598404 0.13222679 0.58276821 1 3.830041882 4.12742254 116987 "ArfGAP with GTPase domain, ankyrin repeat and PH domain 1" "GO:0003924,GO:0005096,GO:0005515,GO:0005525,GO:0005543,GO:0005634,GO:0005737,GO:0015031,GO:0043547,GO:0046872" GTPase activity|GTPase activator activity|protein binding|GTP binding|phospholipid binding|nucleus|cytoplasm|protein transport|positive regulation of GTPase activity|metal ion binding hsa04144 Endocytosis AGAP2 168.899908 157.1024963 180.6973197 1.150187451 0.201869002 0.611496792 1 1.235524828 1.397305217 116986 "ArfGAP with GTPase domain, ankyrin repeat and PH domain 2" "GO:0003924,GO:0005096,GO:0005515,GO:0005524,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005829,GO:0015031,GO:0016020,GO:0016197,GO:0019901,GO:0030036,GO:0030295,GO:0032147,GO:0035014,GO:0042177,GO:0043524,GO:0043547,GO:0045860,GO:0046872,GO:0061903,GO:0070062,GO:0090543" GTPase activity|GTPase activator activity|protein binding|ATP binding|GTP binding|nucleus|nucleoplasm|cytoplasm|endosome|cytosol|protein transport|membrane|endosomal transport|protein kinase binding|actin cytoskeleton organization|protein kinase activator activity|activation of protein kinase activity|phosphatidylinositol 3-kinase regulator activity|negative regulation of protein catabolic process|negative regulation of neuron apoptotic process|positive regulation of GTPase activity|positive regulation of protein kinase activity|metal ion binding|positive regulation of 1-phosphatidylinositol-3-kinase activity|extracellular exosome|Flemming body "hsa04068,hsa04144" FoxO signaling pathway|Endocytosis AGAP3 1116.108543 1077.868782 1154.348303 1.070954389 0.098897038 0.687098063 1 9.390120124 9.888110285 116988 "ArfGAP with GTPase domain, ankyrin repeat and PH domain 3" "GO:0003924,GO:0005096,GO:0005525,GO:0005634,GO:0005737,GO:0007165,GO:0016020,GO:0031593,GO:0034614,GO:0043161,GO:0043547,GO:0046872,GO:0071944" GTPase activity|GTPase activator activity|GTP binding|nucleus|cytoplasm|signal transduction|membrane|polyubiquitin modification-dependent protein binding|cellular response to reactive oxygen species|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of GTPase activity|metal ion binding|cell periphery hsa04144 Endocytosis AGAP4 251.7813884 301.720026 201.8427508 0.668973662 -0.579978682 0.082350314 1 4.209736797 2.769077698 119016 "ArfGAP with GTPase domain, ankyrin repeat and PH domain 4" "GO:0005096,GO:0005634,GO:0043547,GO:0046872" GTPase activator activity|nucleus|positive regulation of GTPase activity|metal ion binding hsa04144 Endocytosis AGAP5 100.3854628 137.3346325 63.4362931 0.461910386 -1.11431511 0.017483645 0.770503287 2.695585482 1.224283551 729092 "ArfGAP with GTPase domain, ankyrin repeat and PH domain 5" "GO:0005096,GO:0005634,GO:0043547,GO:0046872" GTPase activator activity|nucleus|positive regulation of GTPase activity|metal ion binding hsa04144 Endocytosis AGAP6 268.3739046 270.5076095 266.2401998 0.984224438 -0.022940757 0.95653803 1 5.378723527 5.205285374 414189 "ArfGAP with GTPase domain, ankyrin repeat and PH domain 6" "GO:0005096,GO:0005634,GO:0043547,GO:0046872" GTPase activator activity|nucleus|positive regulation of GTPase activity|metal ion binding hsa04144 Endocytosis AGAP9 318.45781 311.0837509 325.8318691 1.047408835 0.066824679 0.83818545 1 6.955160469 7.162993645 642517 "ArfGAP with GTPase domain, ankyrin repeat and PH domain 9" "GO:0005096,GO:0005634,GO:0043547,GO:0046872" GTPase activator activity|nucleus|positive regulation of GTPase activity|metal ion binding hsa04144 Endocytosis AGBL2 52.31821855 61.38441908 43.25201802 0.704609063 -0.505105063 0.399132348 1 0.641467325 0.444420356 79841 AGBL carboxypeptidase 2 "GO:0004181,GO:0005814,GO:0005829,GO:0006508,GO:0008270,GO:0035610,GO:0036064" metallocarboxypeptidase activity|centriole|cytosol|proteolysis|zinc ion binding|protein side chain deglutamylation|ciliary basal body AGBL3 53.24477596 47.8590386 58.63051332 1.225066676 0.292860272 0.636582397 1 0.314318106 0.378617169 340351 AGBL carboxypeptidase 3 "GO:0004181,GO:0005829,GO:0006508,GO:0008270,GO:0035610" metallocarboxypeptidase activity|cytosol|proteolysis|zinc ion binding|protein side chain deglutamylation AGBL5 938.8702325 941.5745638 936.1659011 0.994255726 -0.00831113 0.978014625 1 15.36700426 15.02306308 60509 AGBL carboxypeptidase 5 "GO:0004181,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0008270,GO:0015630,GO:0015631,GO:0030496,GO:0035608,GO:0035611,GO:0045171,GO:0051607,GO:0072686" metallocarboxypeptidase activity|nucleus|cytoplasm|cytosol|proteolysis|zinc ion binding|microtubule cytoskeleton|tubulin binding|midbody|protein deglutamylation|protein branching point deglutamylation|intercellular bridge|defense response to virus|mitotic spindle AGER 32.14400431 36.41448589 27.87352272 0.765451497 -0.385617132 0.609016882 1 1.139140788 0.857366001 177 advanced glycosylation end-product specific receptor "GO:0001540,GO:0001650,GO:0001666,GO:0001774,GO:0001914,GO:0001934,GO:0004888,GO:0005044,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0006897,GO:0006954,GO:0007166,GO:0007611,GO:0009611,GO:0009986,GO:0010255,GO:0016324,GO:0030054,GO:0031175,GO:0032693,GO:0032722,GO:0032731,GO:0032735,GO:0032755,GO:0032760,GO:0034116,GO:0038023,GO:0042104,GO:0042802,GO:0043507,GO:0044548,GO:0044877,GO:0045056,GO:0045087,GO:0046330,GO:0048143,GO:0048167,GO:0050727,GO:0050785,GO:0050930,GO:0051092,GO:0051101,GO:0070374,GO:0071639,GO:0072657,GO:0090647,GO:0098794,GO:0150003,GO:0150104,GO:1900271,GO:1900272,GO:1900453,GO:1900744,GO:1900745,GO:1901222,GO:1901224,GO:1902961,GO:1903523,GO:1904472,GO:1904597,GO:1904645,GO:1904646,GO:2000439,GO:2000514,GO:2001200" "amyloid-beta binding|fibrillar center|response to hypoxia|microglial cell activation|regulation of T cell mediated cytotoxicity|positive regulation of protein phosphorylation|transmembrane signaling receptor activity|scavenger receptor activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|endocytosis|inflammatory response|cell surface receptor signaling pathway|learning or memory|response to wounding|cell surface|glucose mediated signaling pathway|apical plasma membrane|cell junction|neuron projection development|negative regulation of interleukin-10 production|positive regulation of chemokine production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of heterotypic cell-cell adhesion|signaling receptor activity|positive regulation of activated T cell proliferation|identical protein binding|positive regulation of JUN kinase activity|S100 protein binding|protein-containing complex binding|transcytosis|innate immune response|positive regulation of JNK cascade|astrocyte activation|regulation of synaptic plasticity|regulation of inflammatory response|advanced glycation end-product receptor activity|induction of positive chemotaxis|positive regulation of NF-kappaB transcription factor activity|regulation of DNA binding|positive regulation of ERK1 and ERK2 cascade|positive regulation of monocyte chemotactic protein-1 production|protein localization to membrane|modulation of age-related behavioral decline|postsynapse|regulation of spontaneous synaptic transmission|transport across blood-brain barrier|regulation of long-term synaptic potentiation|negative regulation of long-term synaptic potentiation|negative regulation of long-term synaptic depression|regulation of p38MAPK cascade|positive regulation of p38MAPK cascade|regulation of NIK/NF-kappaB signaling|positive regulation of NIK/NF-kappaB signaling|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of blood circulation|positive regulation of endothelin production|negative regulation of connective tissue replacement involved in inflammatory response wound healing|response to amyloid-beta|cellular response to amyloid-beta|positive regulation of monocyte extravasation|regulation of CD4-positive, alpha-beta T cell activation|positive regulation of dendritic cell differentiation" "hsa04933,hsa05010,hsa05022" AGE-RAGE signaling pathway in diabetic complications|Alzheimer disease|Pathways of neurodegeneration - multiple diseases AGFG1 2562.882459 2484.508352 2641.256567 1.063090235 0.088264058 0.709936173 1 15.15529139 15.84183912 3267 ArfGAP with FG repeats 1 "GO:0003677,GO:0003723,GO:0005096,GO:0005515,GO:0005643,GO:0005829,GO:0006406,GO:0007275,GO:0007283,GO:0030154,GO:0031410,GO:0043231,GO:0043547,GO:0046872,GO:0061024" DNA binding|RNA binding|GTPase activator activity|protein binding|nuclear pore|cytosol|mRNA export from nucleus|multicellular organism development|spermatogenesis|cell differentiation|cytoplasmic vesicle|intracellular membrane-bounded organelle|positive regulation of GTPase activity|metal ion binding|membrane organization AGFG2 183.4260734 185.1936711 181.6584757 0.980910819 -0.027806117 0.956849738 1 1.9191157 1.850980578 3268 ArfGAP with FG repeats 2 "GO:0003674,GO:0005096,GO:0008150,GO:0016020,GO:0043547,GO:0046872" molecular_function|GTPase activator activity|biological_process|membrane|positive regulation of GTPase activity|metal ion binding AGGF1 1101.008065 984.231533 1217.784596 1.237294839 0.307189326 0.207809422 1 11.69858084 14.23238098 55109 angiogenic factor with G-patch and FHA domains 1 "GO:0001525,GO:0001570,GO:0001938,GO:0003676,GO:0005515,GO:0005576,GO:0005737,GO:0007155,GO:0045766,GO:0048471" angiogenesis|vasculogenesis|positive regulation of endothelial cell proliferation|nucleic acid binding|protein binding|extracellular region|cytoplasm|cell adhesion|positive regulation of angiogenesis|perinuclear region of cytoplasm AGK 740.8683039 752.2192372 729.5173706 0.969820146 -0.044210871 0.866982353 1 3.500571867 3.338115645 55750 acylglycerol kinase "GO:0001727,GO:0001729,GO:0003951,GO:0004143,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005741,GO:0005743,GO:0005758,GO:0005829,GO:0006665,GO:0016020,GO:0016310,GO:0017050,GO:0031305,GO:0031966,GO:0042721,GO:0043231,GO:0045039,GO:0046474,GO:0046512,GO:0046513,GO:0046834,GO:0047620,GO:0102773" lipid kinase activity|ceramide kinase activity|NAD+ kinase activity|diacylglycerol kinase activity|protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial intermembrane space|cytosol|sphingolipid metabolic process|membrane|phosphorylation|D-erythro-sphingosine kinase activity|integral component of mitochondrial inner membrane|mitochondrial membrane|TIM22 mitochondrial import inner membrane insertion complex|intracellular membrane-bounded organelle|protein insertion into mitochondrial inner membrane|glycerophospholipid biosynthetic process|sphingosine biosynthetic process|ceramide biosynthetic process|lipid phosphorylation|acylglycerol kinase activity|dihydroceramide kinase activity hsa00561 Glycerolipid metabolism AGL 800.0580387 855.2202115 744.8958659 0.870998903 -0.199257193 0.429707341 1 6.70016601 5.73818241 178 "amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase" "GO:0004133,GO:0004134,GO:0004135,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005978,GO:0005980,GO:0007584,GO:0016234,GO:0016529,GO:0030247,GO:0031593,GO:0034774,GO:0043033,GO:0043312,GO:0051384,GO:0102500,GO:1904813" "glycogen debranching enzyme activity|4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|protein binding|extracellular region|nucleus|cytoplasm|cytosol|glycogen biosynthetic process|glycogen catabolic process|response to nutrient|inclusion body|sarcoplasmic reticulum|polysaccharide binding|polyubiquitin modification-dependent protein binding|secretory granule lumen|isoamylase complex|neutrophil degranulation|response to glucocorticoid|beta-maltose 4-alpha-glucanotransferase activity|ficolin-1-rich granule lumen" hsa00500 Starch and sucrose metabolism AGMAT 7.045123399 8.323311061 5.766935736 0.692865579 -0.529352609 0.780164403 1 0.143521749 0.097777265 79814 agmatinase "GO:0005739,GO:0008295,GO:0008783,GO:0033389,GO:0046872,GO:0097055" "mitochondrion|spermidine biosynthetic process|agmatinase activity|putrescine biosynthetic process from arginine, using agmatinase|metal ion binding|agmatine biosynthetic process" hsa00330 Arginine and proline metabolism AGO1 717.2753236 763.6637899 670.8868573 0.878510761 -0.186868137 0.465909659 1 3.117758026 2.693150789 26523 argonaute RISC component 1 "GO:0000932,GO:0000956,GO:0000993,GO:0001046,GO:0003723,GO:0003725,GO:0003727,GO:0004521,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005844,GO:0007223,GO:0010501,GO:0010628,GO:0010629,GO:0016442,GO:0016525,GO:0031054,GO:0035194,GO:0035196,GO:0035198,GO:0035278,GO:0035279,GO:0035280,GO:0036464,GO:0045652,GO:0045944,GO:0060964,GO:0070578,GO:0090502,GO:0090625,GO:1990904" "P-body|nuclear-transcribed mRNA catabolic process|RNA polymerase II complex binding|core promoter sequence-specific DNA binding|RNA binding|double-stranded RNA binding|single-stranded RNA binding|endoribonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|polysome|Wnt signaling pathway, calcium modulating pathway|RNA secondary structure unwinding|positive regulation of gene expression|negative regulation of gene expression|RISC complex|negative regulation of angiogenesis|pre-miRNA processing|post-transcriptional gene silencing by RNA|production of miRNAs involved in gene silencing by miRNA|miRNA binding|miRNA mediated inhibition of translation|mRNA cleavage involved in gene silencing by miRNA|miRNA loading onto RISC involved in gene silencing by miRNA|cytoplasmic ribonucleoprotein granule|regulation of megakaryocyte differentiation|positive regulation of transcription by RNA polymerase II|regulation of gene silencing by miRNA|RISC-loading complex|RNA phosphodiester bond hydrolysis, endonucleolytic|mRNA cleavage involved in gene silencing by siRNA|ribonucleoprotein complex" AGO2 2723.98871 2701.954853 2746.022566 1.016309567 0.023339912 0.922972202 1 7.695915276 7.690551243 27161 argonaute RISC catalytic component 2 "GO:0000340,GO:0000932,GO:0000993,GO:0001046,GO:0003723,GO:0003725,GO:0003727,GO:0003743,GO:0004521,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005844,GO:0005845,GO:0006412,GO:0006413,GO:0007223,GO:0008022,GO:0009791,GO:0010501,GO:0010586,GO:0010628,GO:0010629,GO:0016020,GO:0016442,GO:0030422,GO:0030425,GO:0031047,GO:0031054,GO:0035087,GO:0035194,GO:0035196,GO:0035197,GO:0035198,GO:0035278,GO:0035279,GO:0035280,GO:0036464,GO:0042985,GO:0045766,GO:0045944,GO:0045947,GO:0045975,GO:0046872,GO:0060213,GO:0060964,GO:0070062,GO:0070551,GO:0070578,GO:0090502,GO:0090624,GO:0090625,GO:0098808,GO:1900153,GO:1901165,GO:1905618,GO:1990904" "RNA 7-methylguanosine cap binding|P-body|RNA polymerase II complex binding|core promoter sequence-specific DNA binding|RNA binding|double-stranded RNA binding|single-stranded RNA binding|translation initiation factor activity|endoribonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|polysome|mRNA cap binding complex|translation|translational initiation|Wnt signaling pathway, calcium modulating pathway|protein C-terminus binding|post-embryonic development|RNA secondary structure unwinding|miRNA metabolic process|positive regulation of gene expression|negative regulation of gene expression|membrane|RISC complex|production of siRNA involved in RNA interference|dendrite|gene silencing by RNA|pre-miRNA processing|siRNA loading onto RISC involved in RNA interference|post-transcriptional gene silencing by RNA|production of miRNAs involved in gene silencing by miRNA|siRNA binding|miRNA binding|miRNA mediated inhibition of translation|mRNA cleavage involved in gene silencing by miRNA|miRNA loading onto RISC involved in gene silencing by miRNA|cytoplasmic ribonucleoprotein granule|negative regulation of amyloid precursor protein biosynthetic process|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|negative regulation of translational initiation|positive regulation of translation, ncRNA-mediated|metal ion binding|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of gene silencing by miRNA|extracellular exosome|endoribonuclease activity, cleaving siRNA-paired mRNA|RISC-loading complex|RNA phosphodiester bond hydrolysis, endonucleolytic|endoribonuclease activity, cleaving miRNA-paired mRNA|mRNA cleavage involved in gene silencing by siRNA|mRNA cap binding|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|positive regulation of trophoblast cell migration|positive regulation of miRNA mediated inhibition of translation|ribonucleoprotein complex" AGO3 215.0894997 221.608157 208.5708425 0.941169519 -0.087473498 0.816276258 1 0.989940574 0.916111124 192669 argonaute RISC catalytic component 3 "GO:0000794,GO:0000932,GO:0003723,GO:0003725,GO:0003727,GO:0004521,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006402,GO:0007223,GO:0010501,GO:0010628,GO:0010629,GO:0016020,GO:0016442,GO:0031054,GO:0035194,GO:0035196,GO:0035198,GO:0035278,GO:0035279,GO:0035280,GO:0036464,GO:0045652,GO:0046872,GO:0070578,GO:0072091,GO:0090502,GO:0090624,GO:0090625,GO:1901224" "condensed nuclear chromosome|P-body|RNA binding|double-stranded RNA binding|single-stranded RNA binding|endoribonuclease activity|protein binding|nucleoplasm|cytoplasm|cytosol|mRNA catabolic process|Wnt signaling pathway, calcium modulating pathway|RNA secondary structure unwinding|positive regulation of gene expression|negative regulation of gene expression|membrane|RISC complex|pre-miRNA processing|post-transcriptional gene silencing by RNA|production of miRNAs involved in gene silencing by miRNA|miRNA binding|miRNA mediated inhibition of translation|mRNA cleavage involved in gene silencing by miRNA|miRNA loading onto RISC involved in gene silencing by miRNA|cytoplasmic ribonucleoprotein granule|regulation of megakaryocyte differentiation|metal ion binding|RISC-loading complex|regulation of stem cell proliferation|RNA phosphodiester bond hydrolysis, endonucleolytic|endoribonuclease activity, cleaving miRNA-paired mRNA|mRNA cleavage involved in gene silencing by siRNA|positive regulation of NIK/NF-kappaB signaling" AGO4 528.4590968 537.8939773 519.0242162 0.964919181 -0.051519983 0.855241246 1 4.068369184 3.859957068 192670 argonaute RISC component 4 "GO:0000932,GO:0003725,GO:0003727,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006402,GO:0007130,GO:0007140,GO:0007223,GO:0008584,GO:0010501,GO:0010586,GO:0010628,GO:0010629,GO:0016020,GO:0016442,GO:0022604,GO:0031054,GO:0035194,GO:0035196,GO:0035198,GO:0035278,GO:0035279,GO:0035280,GO:0036464,GO:0043066,GO:0045652,GO:0070578,GO:0090625" "P-body|double-stranded RNA binding|single-stranded RNA binding|protein binding|nucleus|cytoplasm|cytosol|mRNA catabolic process|synaptonemal complex assembly|male meiotic nuclear division|Wnt signaling pathway, calcium modulating pathway|male gonad development|RNA secondary structure unwinding|miRNA metabolic process|positive regulation of gene expression|negative regulation of gene expression|membrane|RISC complex|regulation of cell morphogenesis|pre-miRNA processing|post-transcriptional gene silencing by RNA|production of miRNAs involved in gene silencing by miRNA|miRNA binding|miRNA mediated inhibition of translation|mRNA cleavage involved in gene silencing by miRNA|miRNA loading onto RISC involved in gene silencing by miRNA|cytoplasmic ribonucleoprotein granule|negative regulation of apoptotic process|regulation of megakaryocyte differentiation|RISC-loading complex|mRNA cleavage involved in gene silencing by siRNA" AGPAT1 1055.343096 1009.201466 1101.484726 1.09144186 0.126235282 0.607962501 1 16.7942711 18.02324326 10554 1-acylglycerol-3-phosphate O-acyltransferase 1 "GO:0001819,GO:0001961,GO:0003841,GO:0005515,GO:0005783,GO:0005789,GO:0006644,GO:0006654,GO:0016020,GO:0016021,GO:0016024,GO:0031325" positive regulation of cytokine production|positive regulation of cytokine-mediated signaling pathway|1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|phospholipid metabolic process|phosphatidic acid biosynthetic process|membrane|integral component of membrane|CDP-diacylglycerol biosynthetic process|positive regulation of cellular metabolic process "hsa00561,hsa00564,hsa04072,hsa04975" Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway|Fat digestion and absorption AGPAT2 1199.590102 1124.687407 1274.492798 1.133197357 0.180399142 0.457263412 1 38.8243854 43.25948263 10555 1-acylglycerol-3-phosphate O-acyltransferase 2 "GO:0001819,GO:0001961,GO:0003841,GO:0005783,GO:0005789,GO:0005886,GO:0006644,GO:0006654,GO:0008544,GO:0016021,GO:0016024,GO:0035579,GO:0042493,GO:0043312" positive regulation of cytokine production|positive regulation of cytokine-mediated signaling pathway|1-acylglycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|phospholipid metabolic process|phosphatidic acid biosynthetic process|epidermis development|integral component of membrane|CDP-diacylglycerol biosynthetic process|specific granule membrane|response to drug|neutrophil degranulation "hsa00561,hsa00564,hsa04072,hsa04975" Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway|Fat digestion and absorption AGPAT3 1798.986042 1733.329528 1864.642555 1.075757681 0.105353142 0.65814814 1 10.62416575 11.23777861 56894 1-acylglycerol-3-phosphate O-acyltransferase 3 "GO:0000139,GO:0003841,GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0005886,GO:0006654,GO:0008654,GO:0012505,GO:0016020,GO:0016021,GO:0016024,GO:0016746" "Golgi membrane|1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|phosphatidic acid biosynthetic process|phospholipid biosynthetic process|endomembrane system|membrane|integral component of membrane|CDP-diacylglycerol biosynthetic process|transferase activity, transferring acyl groups" "hsa00561,hsa00564,hsa04072" Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway AGPAT4 466.3261434 483.7924554 448.8598314 0.927794194 -0.108123276 0.702658685 1 3.203364041 2.922329118 56895 1-acylglycerol-3-phosphate O-acyltransferase 4 "GO:0003841,GO:0005515,GO:0005741,GO:0005783,GO:0005789,GO:0006654,GO:0008654,GO:0012505,GO:0016021,GO:0016024,GO:0016746" "1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|phosphatidic acid biosynthetic process|phospholipid biosynthetic process|endomembrane system|integral component of membrane|CDP-diacylglycerol biosynthetic process|transferase activity, transferring acyl groups" "hsa00561,hsa00564,hsa04072" Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway AGPAT5 785.5369037 814.6440701 756.4297374 0.928540163 -0.106963782 0.674730619 1 8.215430229 7.500706698 55326 1-acylglycerol-3-phosphate O-acyltransferase 5 "GO:0002244,GO:0003841,GO:0005515,GO:0005635,GO:0005739,GO:0005741,GO:0005789,GO:0006639,GO:0006654,GO:0008654,GO:0012505,GO:0016021,GO:0016024,GO:0016746" "hematopoietic progenitor cell differentiation|1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding|nuclear envelope|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum membrane|acylglycerol metabolic process|phosphatidic acid biosynthetic process|phospholipid biosynthetic process|endomembrane system|integral component of membrane|CDP-diacylglycerol biosynthetic process|transferase activity, transferring acyl groups" "hsa00561,hsa00564,hsa04072" Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway AGPS 2075.306475 2061.059902 2089.553048 1.013824512 0.01980795 0.935397542 1 12.00425394 11.96655496 8540 alkylglycerone phosphate synthase "GO:0005515,GO:0005730,GO:0005739,GO:0005777,GO:0005778,GO:0005782,GO:0005829,GO:0006625,GO:0008609,GO:0008610,GO:0008611,GO:0016020,GO:0016491,GO:0055114,GO:0071949" protein binding|nucleolus|mitochondrion|peroxisome|peroxisomal membrane|peroxisomal matrix|cytosol|protein targeting to peroxisome|alkylglycerone-phosphate synthase activity|lipid biosynthetic process|ether lipid biosynthetic process|membrane|oxidoreductase activity|oxidation-reduction process|FAD binding "hsa00565,hsa04146" Ether lipid metabolism|Peroxisome AGRN 11899.83792 13203.89258 10595.78326 0.802474209 -0.317473069 0.214492857 1 86.70696192 68.41577193 375790 agrin "GO:0001523,GO:0002162,GO:0005200,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005604,GO:0005796,GO:0005886,GO:0006024,GO:0006027,GO:0007010,GO:0007165,GO:0007213,GO:0007528,GO:0009887,GO:0009888,GO:0016021,GO:0030198,GO:0033691,GO:0035374,GO:0043113,GO:0043202,GO:0043236,GO:0043395,GO:0043547,GO:0045162,GO:0045202,GO:0045887,GO:0045944,GO:0050808,GO:0051491,GO:0062023,GO:0070062" retinoid metabolic process|dystroglycan binding|structural constituent of cytoskeleton|extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|basement membrane|Golgi lumen|plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|cytoskeleton organization|signal transduction|G protein-coupled acetylcholine receptor signaling pathway|neuromuscular junction development|animal organ morphogenesis|tissue development|integral component of membrane|extracellular matrix organization|sialic acid binding|chondroitin sulfate binding|receptor clustering|lysosomal lumen|laminin binding|heparan sulfate proteoglycan binding|positive regulation of GTPase activity|clustering of voltage-gated sodium channels|synapse|positive regulation of synaptic growth at neuromuscular junction|positive regulation of transcription by RNA polymerase II|synapse organization|positive regulation of filopodium assembly|collagen-containing extracellular matrix|extracellular exosome hsa04512 ECM-receptor interaction AGTPBP1 736.1122139 728.2897178 743.9347099 1.021481825 0.030663534 0.909540861 1 3.203188042 3.217245905 23287 ATP/GTP binding carboxypeptidase 1 "GO:0001754,GO:0004181,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0006508,GO:0007005,GO:0008270,GO:0015631,GO:0021702,GO:0021772,GO:0035608,GO:0035609,GO:0035610,GO:0043231,GO:0050905" eye photoreceptor cell differentiation|metallocarboxypeptidase activity|nucleus|nucleolus|cytoplasm|mitochondrion|cytosol|proteolysis|mitochondrion organization|zinc ion binding|tubulin binding|cerebellar Purkinje cell differentiation|olfactory bulb development|protein deglutamylation|C-terminal protein deglutamylation|protein side chain deglutamylation|intracellular membrane-bounded organelle|neuromuscular process AGTRAP 941.1095761 949.8978749 932.3212773 0.981496329 -0.026945223 0.917643374 1 40.32959725 38.92097788 57085 angiotensin II receptor associated protein "GO:0000139,GO:0001666,GO:0004945,GO:0005515,GO:0005789,GO:0005794,GO:0005886,GO:0005938,GO:0008217,GO:0016021,GO:0030659,GO:0038166,GO:0043231" Golgi membrane|response to hypoxia|angiotensin type II receptor activity|protein binding|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|cell cortex|regulation of blood pressure|integral component of membrane|cytoplasmic vesicle membrane|angiotensin-activated signaling pathway|intracellular membrane-bounded organelle AGXT2 23.85529179 33.29324424 14.41733934 0.433040987 -1.207424514 0.130217901 1 0.799639629 0.340482262 64902 alanine--glyoxylate aminotransferase 2 "GO:0005739,GO:0005759,GO:0008453,GO:0009436,GO:0019265,GO:0019481,GO:0030170,GO:0045429,GO:0046487,GO:0047305" "mitochondrion|mitochondrial matrix|alanine-glyoxylate transaminase activity|glyoxylate catabolic process|glycine biosynthetic process, by transamination of glyoxylate|L-alanine catabolic process, by transamination|pyridoxal phosphate binding|positive regulation of nitric oxide biosynthetic process|glyoxylate metabolic process|(R)-3-amino-2-methylpropionate-pyruvate transaminase activity" "hsa00250,hsa00260,hsa00270,hsa00280" "Alanine, aspartate and glutamate metabolism|Glycine, serine and threonine metabolism|Cysteine and methionine metabolism|Valine, leucine and isoleucine degradation" AHCTF1 2671.356647 2922.522596 2420.190697 0.828117018 -0.272093451 0.249898981 1 17.26473983 14.05798016 25909 AT-hook containing transcription factor 1 "GO:0000777,GO:0000785,GO:0003677,GO:0005634,GO:0005643,GO:0005654,GO:0005829,GO:0007049,GO:0015031,GO:0016363,GO:0031080,GO:0031965,GO:0032465,GO:0051028,GO:0051292,GO:0051301,GO:0070062" condensed chromosome kinetochore|chromatin|DNA binding|nucleus|nuclear pore|nucleoplasm|cytosol|cell cycle|protein transport|nuclear matrix|nuclear pore outer ring|nuclear membrane|regulation of cytokinesis|mRNA transport|nuclear pore complex assembly|cell division|extracellular exosome AHCY 5910.251348 5806.549879 6013.952817 1.03571879 0.050632348 0.834814117 1 70.17320993 71.46351555 191 adenosylhomocysteinase "GO:0000096,GO:0001666,GO:0002439,GO:0004013,GO:0005515,GO:0005634,GO:0005829,GO:0006730,GO:0007584,GO:0019510,GO:0030554,GO:0032259,GO:0033353,GO:0042470,GO:0042745,GO:0042802,GO:0043005,GO:0051287,GO:0070062" sulfur amino acid metabolic process|response to hypoxia|chronic inflammatory response to antigenic stimulus|adenosylhomocysteinase activity|protein binding|nucleus|cytosol|one-carbon metabolic process|response to nutrient|S-adenosylhomocysteine catabolic process|adenyl nucleotide binding|methylation|S-adenosylmethionine cycle|melanosome|circadian sleep/wake cycle|identical protein binding|neuron projection|NAD binding|extracellular exosome hsa00270 Cysteine and methionine metabolism AHCYL1 4628.418859 4541.406598 4715.43112 1.03831952 0.05425047 0.821370698 1 52.8492201 53.95612848 10768 adenosylhomocysteinase like 1 "GO:0003723,GO:0004013,GO:0005515,GO:0005737,GO:0005789,GO:0005829,GO:0006378,GO:0006611,GO:0006730,GO:0006915,GO:0010765,GO:0016324,GO:0031440,GO:0032412,GO:0033353,GO:0038166,GO:0042045,GO:0042802,GO:0044070,GO:0044233,GO:0051592,GO:0070062,GO:1903779,GO:1990456" RNA binding|adenosylhomocysteinase activity|protein binding|cytoplasm|endoplasmic reticulum membrane|cytosol|mRNA polyadenylation|protein export from nucleus|one-carbon metabolic process|apoptotic process|positive regulation of sodium ion transport|apical plasma membrane|regulation of mRNA 3'-end processing|regulation of ion transmembrane transporter activity|S-adenosylmethionine cycle|angiotensin-activated signaling pathway|epithelial fluid transport|identical protein binding|regulation of anion transport|mitochondria-associated endoplasmic reticulum membrane|response to calcium ion|extracellular exosome|regulation of cardiac conduction|mitochondrion-endoplasmic reticulum membrane tethering hsa00270 Cysteine and methionine metabolism AHCYL2 828.6505276 760.5425482 896.7585069 1.179103666 0.237690565 0.34367023 1 5.287059786 6.129674171 23382 adenosylhomocysteinase like 2 "GO:0004013,GO:0005515,GO:0005783,GO:0005829,GO:0006730,GO:0033353,GO:0043005" adenosylhomocysteinase activity|protein binding|endoplasmic reticulum|cytosol|one-carbon metabolic process|S-adenosylmethionine cycle|neuron projection hsa00270 Cysteine and methionine metabolism AHDC1 283.2466699 332.9324424 233.5608973 0.701526399 -0.511430701 0.111482398 1 2.196833896 1.515348131 27245 AT-hook DNA binding motif containing 1 "GO:0003677,GO:0005515" DNA binding|protein binding AHI1 368.6109124 378.7106533 358.5111716 0.946662494 -0.07907793 0.797122005 1 2.681938897 2.496406063 54806 Abelson helper integration site 1 "GO:0001738,GO:0001947,GO:0002092,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0005911,GO:0005912,GO:0005929,GO:0007169,GO:0007417,GO:0010842,GO:0016192,GO:0030862,GO:0030902,GO:0034613,GO:0035844,GO:0035845,GO:0036038,GO:0036064,GO:0039008,GO:0039023,GO:0042802,GO:0043066,GO:0045944,GO:0050795,GO:0060271,GO:0065001,GO:0070121,GO:0070986,GO:0071599,GO:0097711,GO:0097730" morphogenesis of a polarized epithelium|heart looping|positive regulation of receptor internalization|protein binding|centrosome|centriole|cytosol|cell-cell junction|adherens junction|cilium|transmembrane receptor protein tyrosine kinase signaling pathway|central nervous system development|retina layer formation|vesicle-mediated transport|positive regulation of polarized epithelial cell differentiation|hindbrain development|cellular protein localization|cloaca development|photoreceptor cell outer segment organization|MKS complex|ciliary basal body|pronephric nephron tubule morphogenesis|pronephric duct morphogenesis|identical protein binding|negative regulation of apoptotic process|positive regulation of transcription by RNA polymerase II|regulation of behavior|cilium assembly|specification of axis polarity|Kupffer's vesicle development|left/right axis specification|otic vesicle development|ciliary basal body-plasma membrane docking|non-motile cilium AHNAK 44932.61596 46077.85003 43787.38189 0.950291341 -0.073558212 0.817284965 1 126.8422226 118.5200412 79026 AHNAK nucleoprotein "GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0005765,GO:0005829,GO:0005886,GO:0005925,GO:0015629,GO:0016020,GO:0030315,GO:0031982,GO:0042383,GO:0043034,GO:0043484,GO:0044291,GO:0044548,GO:0045121,GO:0045296,GO:0070062,GO:0097493,GO:1901385" RNA binding|protein binding|nucleus|cytoplasm|lysosomal membrane|cytosol|plasma membrane|focal adhesion|actin cytoskeleton|membrane|T-tubule|vesicle|sarcolemma|costamere|regulation of RNA splicing|cell-cell contact zone|S100 protein binding|membrane raft|cadherin binding|extracellular exosome|structural molecule activity conferring elasticity|regulation of voltage-gated calcium channel activity hsa05132 Salmonella infection AHNAK2 3715.170902 3919.239096 3511.102707 0.895863361 -0.158649389 0.504705107 1 11.25195477 9.911535286 113146 AHNAK nucleoprotein 2 "GO:0001778,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0030018,GO:0030315,GO:0030659,GO:0042383,GO:0043034,GO:0043484" plasma membrane repair|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|Z disc|T-tubule|cytoplasmic vesicle membrane|sarcolemma|costamere|regulation of RNA splicing hsa05132 Salmonella infection AHR 667.9091556 830.2502783 505.5680329 0.608934494 -0.715641057 0.005625018 0.45516052 7.097378091 4.249518222 196 aryl hydrocarbon receptor "GO:0000785,GO:0000976,GO:0000981,GO:0000987,GO:0001094,GO:0001223,GO:0001568,GO:0003677,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0006805,GO:0006915,GO:0007049,GO:0008134,GO:0009410,GO:0009636,GO:0010468,GO:0017025,GO:0019933,GO:0030522,GO:0030888,GO:0032922,GO:0032991,GO:0034751,GO:0034752,GO:0042803,GO:0045892,GO:0045893,GO:0046982,GO:0051879,GO:0070888,GO:0071320,GO:1904322,GO:1904613,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|TFIID-class transcription factor complex binding|transcription coactivator binding|blood vessel development|DNA binding|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|xenobiotic metabolic process|apoptotic process|cell cycle|transcription factor binding|response to xenobiotic stimulus|response to toxic substance|regulation of gene expression|TBP-class protein binding|cAMP-mediated signaling|intracellular receptor signaling pathway|regulation of B cell proliferation|circadian regulation of gene expression|protein-containing complex|aryl hydrocarbon receptor complex|cytosolic aryl hydrocarbon receptor complex|protein homodimerization activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein heterodimerization activity|Hsp90 protein binding|E-box binding|cellular response to cAMP|cellular response to forskolin|cellular response to 2,3,7,8-tetrachlorodibenzodioxine|sequence-specific double-stranded DNA binding" "hsa04659,hsa04934" Th17 cell differentiation|Cushing syndrome bHLH AHRR 54.64688093 46.81862472 62.47513714 1.334407781 0.416199607 0.485272178 1 0.437281056 0.573746973 57491 aryl-hydrocarbon receptor repressor "GO:0000785,GO:0000976,GO:0000981,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006805,GO:0030522,GO:0034751,GO:0046983" "chromatin|transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|xenobiotic metabolic process|intracellular receptor signaling pathway|aryl hydrocarbon receptor complex|protein dimerization activity" bHLH AHSA1 2184.610298 2129.727218 2239.493377 1.051540009 0.072503743 0.760526758 1 78.22410691 80.87933902 10598 activator of HSP90 ATPase activity 1 "GO:0001671,GO:0005515,GO:0005783,GO:0005829,GO:0006457,GO:0016032,GO:0032781,GO:0045296,GO:0051087,GO:0051879,GO:0070062" ATPase activator activity|protein binding|endoplasmic reticulum|cytosol|protein folding|viral process|positive regulation of ATPase activity|cadherin binding|chaperone binding|Hsp90 protein binding|extracellular exosome AIDA 1573.095499 1581.429102 1564.761896 0.989460669 -0.015285734 0.951693655 1 28.36906373 27.60035812 64853 "axin interactor, dorsalization associated" "GO:0005515,GO:0005575,GO:0005737,GO:0009953,GO:0016020,GO:0019904,GO:0031333,GO:0035091,GO:0043508,GO:0046329,GO:0048264" protein binding|cellular_component|cytoplasm|dorsal/ventral pattern formation|membrane|protein domain specific binding|negative regulation of protein-containing complex assembly|phosphatidylinositol binding|negative regulation of JUN kinase activity|negative regulation of JNK cascade|determination of ventral identity AIF1L 39.3577044 23.9295193 54.78588949 2.289468869 1.195012948 0.070248578 1 0.351520634 0.791328386 83543 allograft inflammatory factor 1 like "GO:0005509,GO:0005737,GO:0005884,GO:0005925,GO:0015629,GO:0032587,GO:0032991,GO:0051015,GO:0051017,GO:0070062,GO:0097178" calcium ion binding|cytoplasm|actin filament|focal adhesion|actin cytoskeleton|ruffle membrane|protein-containing complex|actin filament binding|actin filament bundle assembly|extracellular exosome|ruffle assembly AIFM1 1283.982514 1296.355698 1271.60933 0.980910819 -0.027806117 0.911383546 1 21.5661225 20.80045194 9131 apoptosis inducing factor mitochondria associated 1 "GO:0003677,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005758,GO:0005829,GO:0006915,GO:0006919,GO:0016174,GO:0016651,GO:0030261,GO:0033108,GO:0043065,GO:0045041,GO:0046983,GO:0048471,GO:0055114,GO:0070059,GO:0071949" "DNA binding|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|NAD(P)H oxidase H2O2-forming activity|oxidoreductase activity, acting on NAD(P)H|chromosome condensation|mitochondrial respiratory chain complex assembly|positive regulation of apoptotic process|protein import into mitochondrial intermembrane space|protein dimerization activity|perinuclear region of cytoplasm|oxidation-reduction process|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|FAD binding" "hsa04210,hsa04217" Apoptosis|Necroptosis AIFM2 552.9383912 612.8037769 493.0730054 0.804618092 -0.313623918 0.240940647 1 10.4253144 8.248028123 84883 apoptosis inducing factor mitochondria associated 2 "GO:0003677,GO:0004174,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005739,GO:0005741,GO:0005811,GO:0005829,GO:0005886,GO:0006743,GO:0008637,GO:0016021,GO:0016655,GO:0022904,GO:0042981,GO:0043065,GO:0050660,GO:0110076,GO:1900407" "DNA binding|electron-transferring-flavoprotein dehydrogenase activity|protein binding|extracellular space|nucleus|cytoplasm|mitochondrion|mitochondrial outer membrane|lipid droplet|cytosol|plasma membrane|ubiquinone metabolic process|apoptotic mitochondrial changes|integral component of membrane|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|respiratory electron transport chain|regulation of apoptotic process|positive regulation of apoptotic process|flavin adenine dinucleotide binding|negative regulation of ferroptosis|regulation of cellular response to oxidative stress" hsa04115 p53 signaling pathway AIFM3 9.046693237 10.40413883 7.689247648 0.739056617 -0.436243205 0.791668951 1 0.232516653 0.168967412 150209 apoptosis inducing factor mitochondria associated 3 "GO:0005634,GO:0005739,GO:0005743,GO:0005783,GO:0005829,GO:0016491,GO:0046872,GO:0050660,GO:0051537,GO:0055114,GO:0097194" "nucleus|mitochondrion|mitochondrial inner membrane|endoplasmic reticulum|cytosol|oxidoreductase activity|metal ion binding|flavin adenine dinucleotide binding|2 iron, 2 sulfur cluster binding|oxidation-reduction process|execution phase of apoptosis" AIG1 846.8477097 821.9269673 871.7684521 1.060639797 0.084934788 0.737591393 1 4.357279389 4.544169319 51390 androgen induced 1 "GO:0005515,GO:0005886,GO:0016020,GO:0016021,GO:0016787,GO:0042758" protein binding|plasma membrane|membrane|integral component of membrane|hydrolase activity|long-chain fatty acid catabolic process AIMP1 1087.403426 955.0999443 1219.706908 1.277046361 0.352810901 0.148333075 1 11.60563038 14.57291988 9255 aminoacyl tRNA synthetase complex interacting multifunctional protein 1 "GO:0000049,GO:0001525,GO:0001937,GO:0005125,GO:0005515,GO:0005615,GO:0005634,GO:0005783,GO:0005794,GO:0005829,GO:0006418,GO:0006915,GO:0006954,GO:0007165,GO:0007267,GO:0009986,GO:0016020,GO:0017101,GO:0042803,GO:0050900,GO:0051020,GO:0051607,GO:0070094" tRNA binding|angiogenesis|negative regulation of endothelial cell proliferation|cytokine activity|protein binding|extracellular space|nucleus|endoplasmic reticulum|Golgi apparatus|cytosol|tRNA aminoacylation for protein translation|apoptotic process|inflammatory response|signal transduction|cell-cell signaling|cell surface|membrane|aminoacyl-tRNA synthetase multienzyme complex|protein homodimerization activity|leukocyte migration|GTPase binding|defense response to virus|positive regulation of glucagon secretion AIMP2 444.293784 498.3582498 390.2293181 0.783029715 -0.352861038 0.209819543 1 12.58110873 9.68653244 7965 aminoacyl tRNA synthetase complex interacting multifunctional protein 2 "GO:0005515,GO:0005634,GO:0005829,GO:0006418,GO:0006915,GO:0008285,GO:0016020,GO:0017101,GO:0031398,GO:0060090,GO:0060510,GO:0065003,GO:1901216,GO:1903632" protein binding|nucleus|cytosol|tRNA aminoacylation for protein translation|apoptotic process|negative regulation of cell population proliferation|membrane|aminoacyl-tRNA synthetase multienzyme complex|positive regulation of protein ubiquitination|molecular adaptor activity|type II pneumocyte differentiation|protein-containing complex assembly|positive regulation of neuron death|positive regulation of aminoacyl-tRNA ligase activity AIP 1105.555949 1027.928916 1183.182982 1.1510358 0.202932705 0.405897384 1 31.40164682 35.53959174 9049 aryl hydrocarbon receptor interacting protein "GO:0000413,GO:0003713,GO:0003755,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006626,GO:0006805,GO:0008134,GO:0010738,GO:0017162,GO:0022417,GO:0034751,GO:0035722,GO:0036004,GO:0045893,GO:0051082,GO:0051344" "protein peptidyl-prolyl isomerization|transcription coactivator activity|peptidyl-prolyl cis-trans isomerase activity|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|protein targeting to mitochondrion|xenobiotic metabolic process|transcription factor binding|regulation of protein kinase A signaling|aryl hydrocarbon receptor binding|protein maturation by protein folding|aryl hydrocarbon receptor complex|interleukin-12-mediated signaling pathway|GAF domain binding|positive regulation of transcription, DNA-templated|unfolded protein binding|negative regulation of cyclic-nucleotide phosphodiesterase activity" hsa04934 Cushing syndrome AJM1 104.0816316 108.2030438 99.96021942 0.923820772 -0.11431511 0.822851341 1 1.243989138 1.129992315 389813 apical junction component 1 homolog "GO:0005912,GO:0005929,GO:0016324,GO:0045216" adherens junction|cilium|apical plasma membrane|cell-cell junction organization AJUBA 2005.973684 2183.82874 1828.118628 0.837116297 -0.25650003 0.278413072 1 24.65036509 20.28991985 84962 ajuba LIM protein "GO:0000086,GO:0000122,GO:0000932,GO:0001666,GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005794,GO:0005815,GO:0005829,GO:0005886,GO:0005911,GO:0005912,GO:0005925,GO:0006355,GO:0007010,GO:0016339,GO:0030027,GO:0030032,GO:0030334,GO:0031328,GO:0031334,GO:0033673,GO:0034613,GO:0035195,GO:0035313,GO:0035331,GO:0043087,GO:0043123,GO:0043406,GO:0045294,GO:0046474,GO:0046872,GO:0048041,GO:0051015,GO:1900037,GO:2000637" "G2/M transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|P-body|response to hypoxia|chromatin binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|Golgi apparatus|microtubule organizing center|cytosol|plasma membrane|cell-cell junction|adherens junction|focal adhesion|regulation of transcription, DNA-templated|cytoskeleton organization|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|lamellipodium|lamellipodium assembly|regulation of cell migration|positive regulation of cellular biosynthetic process|positive regulation of protein-containing complex assembly|negative regulation of kinase activity|cellular protein localization|gene silencing by miRNA|wound healing, spreading of epidermal cells|negative regulation of hippo signaling|regulation of GTPase activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAP kinase activity|alpha-catenin binding|glycerophospholipid biosynthetic process|metal ion binding|focal adhesion assembly|actin filament binding|regulation of cellular response to hypoxia|positive regulation of gene silencing by miRNA" "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species AK1 736.2807906 707.4814402 765.080141 1.081413727 0.112918574 0.660499801 1 12.40373987 13.18911656 203 adenylate kinase 1 "GO:0004017,GO:0004550,GO:0005524,GO:0005737,GO:0005829,GO:0006163,GO:0006165,GO:0006172,GO:0009142,GO:0015949,GO:0046033,GO:0046034,GO:0046940,GO:0070062" adenylate kinase activity|nucleoside diphosphate kinase activity|ATP binding|cytoplasm|cytosol|purine nucleotide metabolic process|nucleoside diphosphate phosphorylation|ADP biosynthetic process|nucleoside triphosphate biosynthetic process|nucleobase-containing small molecule interconversion|AMP metabolic process|ATP metabolic process|nucleoside monophosphate phosphorylation|extracellular exosome "hsa00230,hsa00730" Purine metabolism|Thiamine metabolism AK2 3207.337643 3279.384558 3135.290728 0.95606071 -0.064825863 0.785391166 1 28.53190848 26.82177233 204 adenylate kinase 2 "GO:0004017,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005758,GO:0006163,GO:0006172,GO:0009132,GO:0015949,GO:0016310,GO:0046033,GO:0046034,GO:0046940,GO:0070062,GO:0097226" adenylate kinase activity|protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial intermembrane space|purine nucleotide metabolic process|ADP biosynthetic process|nucleoside diphosphate metabolic process|nucleobase-containing small molecule interconversion|phosphorylation|AMP metabolic process|ATP metabolic process|nucleoside monophosphate phosphorylation|extracellular exosome|sperm mitochondrial sheath "hsa00230,hsa00730" Purine metabolism|Thiamine metabolism AK3 1776.805227 1718.763734 1834.84672 1.067538652 0.094288306 0.692473791 1 20.31611551 21.32531527 50808 adenylate kinase 3 "GO:0004017,GO:0005515,GO:0005524,GO:0005525,GO:0005737,GO:0005739,GO:0005759,GO:0006163,GO:0006172,GO:0007596,GO:0009142,GO:0016310,GO:0046033,GO:0046039,GO:0046041,GO:0046051,GO:0046899,GO:0046940" adenylate kinase activity|protein binding|ATP binding|GTP binding|cytoplasm|mitochondrion|mitochondrial matrix|purine nucleotide metabolic process|ADP biosynthetic process|blood coagulation|nucleoside triphosphate biosynthetic process|phosphorylation|AMP metabolic process|GTP metabolic process|ITP metabolic process|UTP metabolic process|nucleoside triphosphate adenylate kinase activity|nucleoside monophosphate phosphorylation hsa00230 Purine metabolism AK4 799.4094984 775.1083426 823.7106543 1.062703894 0.087739669 0.731072834 1 5.500080794 5.747149836 205 adenylate kinase 4 "GO:0001889,GO:0002082,GO:0004017,GO:0004550,GO:0005515,GO:0005524,GO:0005525,GO:0005737,GO:0005739,GO:0005759,GO:0006163,GO:0006165,GO:0006172,GO:0007420,GO:0009142,GO:0015949,GO:0042493,GO:0046033,GO:0046034,GO:0046039,GO:0046899,GO:0046940,GO:0050145,GO:0071456,GO:2001169" liver development|regulation of oxidative phosphorylation|adenylate kinase activity|nucleoside diphosphate kinase activity|protein binding|ATP binding|GTP binding|cytoplasm|mitochondrion|mitochondrial matrix|purine nucleotide metabolic process|nucleoside diphosphate phosphorylation|ADP biosynthetic process|brain development|nucleoside triphosphate biosynthetic process|nucleobase-containing small molecule interconversion|response to drug|AMP metabolic process|ATP metabolic process|GTP metabolic process|nucleoside triphosphate adenylate kinase activity|nucleoside monophosphate phosphorylation|nucleoside monophosphate kinase activity|cellular response to hypoxia|regulation of ATP biosynthetic process "hsa00230,hsa00730" Purine metabolism|Thiamine metabolism AK5 455.2929716 433.8525891 476.7333542 1.098837177 0.135977627 0.631439431 1 3.344008563 3.613032798 26289 adenylate kinase 5 "GO:0004017,GO:0004550,GO:0005524,GO:0005737,GO:0005829,GO:0006163,GO:0006165,GO:0006172,GO:0006173,GO:0009142,GO:0009220,GO:0015949,GO:0034451,GO:0046034,GO:0046940" adenylate kinase activity|nucleoside diphosphate kinase activity|ATP binding|cytoplasm|cytosol|purine nucleotide metabolic process|nucleoside diphosphate phosphorylation|ADP biosynthetic process|dADP biosynthetic process|nucleoside triphosphate biosynthetic process|pyrimidine ribonucleotide biosynthetic process|nucleobase-containing small molecule interconversion|centriolar satellite|ATP metabolic process|nucleoside monophosphate phosphorylation "hsa00230,hsa00730" Purine metabolism|Thiamine metabolism AK6 252.906705 192.4765683 313.3368417 1.627922009 0.703031584 0.035301594 0.95006405 5.725819784 9.165210585 102157402 adenylate kinase 6 "GO:0004017,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0015030,GO:0015949,GO:0016020,GO:0016310,GO:0016607,GO:0016887,GO:0046940,GO:0050145" adenylate kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|cytosol|Cajal body|nucleobase-containing small molecule interconversion|membrane|phosphorylation|nuclear speck|ATPase activity|nucleoside monophosphate phosphorylation|nucleoside monophosphate kinase activity "hsa00230,hsa03008" Purine metabolism|Ribosome biogenesis in eukaryotes AK7 78.37825541 89.47559391 67.28091692 0.75194714 -0.411296848 0.426582597 1 1.309335892 0.968076245 122481 adenylate kinase 7 "GO:0004017,GO:0004127,GO:0004550,GO:0005524,GO:0005737,GO:0005829,GO:0006163,GO:0006165,GO:0009142,GO:0015949,GO:0030030,GO:0031514,GO:0046940" adenylate kinase activity|cytidylate kinase activity|nucleoside diphosphate kinase activity|ATP binding|cytoplasm|cytosol|purine nucleotide metabolic process|nucleoside diphosphate phosphorylation|nucleoside triphosphate biosynthetic process|nucleobase-containing small molecule interconversion|cell projection organization|motile cilium|nucleoside monophosphate phosphorylation "hsa00230,hsa00730" Purine metabolism|Thiamine metabolism AK8 7.887392465 5.202069413 10.57271552 2.032405698 1.023188414 0.464422034 1 0.046441098 0.092807711 158067 adenylate kinase 8 "GO:0004017,GO:0004127,GO:0004550,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005930,GO:0006163,GO:0006165,GO:0009142,GO:0015949,GO:0021591,GO:0036126,GO:0046940" adenylate kinase activity|cytidylate kinase activity|nucleoside diphosphate kinase activity|protein binding|ATP binding|cytoplasm|cytosol|axoneme|purine nucleotide metabolic process|nucleoside diphosphate phosphorylation|nucleoside triphosphate biosynthetic process|nucleobase-containing small molecule interconversion|ventricular system development|sperm flagellum|nucleoside monophosphate phosphorylation "hsa00230,hsa00730" Purine metabolism|Thiamine metabolism AK9 58.24367014 65.54607461 50.94126567 0.777182554 -0.363674579 0.534171652 1 0.310332996 0.23714948 221264 adenylate kinase 9 "GO:0004017,GO:0004550,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006163,GO:0006174,GO:0006186,GO:0006756,GO:0006757,GO:0009132,GO:0015949,GO:0031965,GO:0050145,GO:0061508,GO:0061565,GO:0061566,GO:0061567,GO:0061568,GO:0061569,GO:0061570,GO:0061571" adenylate kinase activity|nucleoside diphosphate kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|purine nucleotide metabolic process|dADP phosphorylation|dGDP phosphorylation|AMP phosphorylation|ATP generation from ADP|nucleoside diphosphate metabolic process|nucleobase-containing small molecule interconversion|nuclear membrane|nucleoside monophosphate kinase activity|CDP phosphorylation|dAMP phosphorylation|CMP phosphorylation|dCMP phosphorylation|GDP phosphorylation|UDP phosphorylation|dCDP phosphorylation|TDP phosphorylation "hsa00230,hsa00240" Purine metabolism|Pyrimidine metabolism AKAP1 802.2678142 837.5331755 767.0024529 0.915787548 -0.126915147 0.616594612 1 8.793548349 7.918265659 8165 A-kinase anchoring protein 1 "GO:0003723,GO:0005515,GO:0005739,GO:0005741,GO:0005829,GO:0006915,GO:0007596,GO:0016020,GO:0016021,GO:0034237,GO:0140374" RNA binding|protein binding|mitochondrion|mitochondrial outer membrane|cytosol|apoptotic process|blood coagulation|membrane|integral component of membrane|protein kinase A regulatory subunit binding|antiviral innate immune response AKAP10 769.0739496 723.0876484 815.0602507 1.127194265 0.172736177 0.496517534 1 9.497873202 10.52679866 11216 A-kinase anchoring protein 10 "GO:0005515,GO:0005739,GO:0005829,GO:0005886,GO:0007165,GO:0007596,GO:0008104,GO:0032991,GO:0051018" protein binding|mitochondrion|cytosol|plasma membrane|signal transduction|blood coagulation|protein localization|protein-containing complex|protein kinase A binding AKAP11 2445.387461 2667.621195 2223.153726 0.833384339 -0.262946106 0.265998569 1 13.6614567 11.19472742 11215 A-kinase anchoring protein 11 "GO:0003091,GO:0005515,GO:0005730,GO:0005737,GO:0005777,GO:0005815,GO:0005829,GO:0005886,GO:0008104,GO:0008157,GO:0019207,GO:0030866,GO:0034237,GO:0035556,GO:0036010,GO:0043549,GO:0051018" renal water homeostasis|protein binding|nucleolus|cytoplasm|peroxisome|microtubule organizing center|cytosol|plasma membrane|protein localization|protein phosphatase 1 binding|kinase regulator activity|cortical actin cytoskeleton organization|protein kinase A regulatory subunit binding|intracellular signal transduction|protein localization to endosome|regulation of kinase activity|protein kinase A binding AKAP12 10963.14939 9531.231579 12395.06721 1.300468581 0.379031545 0.135212254 1 46.27165575 59.16789015 9590 A-kinase anchoring protein 12 "GO:0005515,GO:0005516,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0005938,GO:0007186,GO:0007193,GO:0008179,GO:0010738,GO:0010739,GO:0032496,GO:0035733,GO:0043025,GO:0043116,GO:0050804,GO:0051018,GO:0051602,GO:0051770,GO:0061870,GO:0070374,GO:0071347,GO:0071356,GO:0090036,GO:0098685,GO:1900143" protein binding|calmodulin binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|focal adhesion|cell cortex|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|adenylate cyclase binding|regulation of protein kinase A signaling|positive regulation of protein kinase A signaling|response to lipopolysaccharide|hepatic stellate cell activation|neuronal cell body|negative regulation of vascular permeability|modulation of chemical synaptic transmission|protein kinase A binding|response to electrical stimulus|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of hepatic stellate cell migration|positive regulation of ERK1 and ERK2 cascade|cellular response to interleukin-1|cellular response to tumor necrosis factor|regulation of protein kinase C signaling|Schaffer collateral - CA1 synapse|positive regulation of oligodendrocyte apoptotic process AKAP13 1732.318452 1900.836164 1563.80074 0.822690966 -0.281577493 0.235489482 1 7.448721085 6.025451842 11214 A-kinase anchoring protein 13 "GO:0004691,GO:0005078,GO:0005085,GO:0005515,GO:0005634,GO:0005829,GO:0005938,GO:0006468,GO:0007186,GO:0007507,GO:0015629,GO:0016020,GO:0030864,GO:0031267,GO:0035023,GO:0035025,GO:0043065,GO:0043123,GO:0043406,GO:0046872,GO:0048471,GO:0051018,GO:0051056,GO:0051168,GO:0055007,GO:0060090,GO:0060297,GO:0060348,GO:0061049,GO:0071875,GO:0086023" cAMP-dependent protein kinase activity|MAP-kinase scaffold activity|guanyl-nucleotide exchange factor activity|protein binding|nucleus|cytosol|cell cortex|protein phosphorylation|G protein-coupled receptor signaling pathway|heart development|actin cytoskeleton|membrane|cortical actin cytoskeleton|small GTPase binding|regulation of Rho protein signal transduction|positive regulation of Rho protein signal transduction|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAP kinase activity|metal ion binding|perinuclear region of cytoplasm|protein kinase A binding|regulation of small GTPase mediated signal transduction|nuclear export|cardiac muscle cell differentiation|molecular adaptor activity|regulation of sarcomere organization|bone development|cell growth involved in cardiac muscle cell development|adrenergic receptor signaling pathway|adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process "hsa04928,hsa05163" "Parathyroid hormone synthesis, secretion and action|Human cytomegalovirus infection" AKAP17A-2 15.4527228 14.56579436 16.33965125 1.121782366 0.165792809 0.933361885 1 0.24299771 0.268029112 8227 A-kinase anchoring protein 17A AKAP5 37.50961999 38.49531366 36.52392633 0.948788901 -0.075840962 0.952619866 1 0.316698649 0.295452035 9495 A-kinase anchoring protein 5 "GO:0005515,GO:0005516,GO:0005829,GO:0005886,GO:0007165,GO:0007193,GO:0007194,GO:0007268,GO:0008179,GO:0009898,GO:0010738,GO:0014069,GO:0017124,GO:0030346,GO:0031698,GO:0032590,GO:0034237,GO:0035254,GO:0043197,GO:0045121,GO:0045762,GO:0050811,GO:0051018,GO:0060076,GO:0060090,GO:0097110,GO:0098837,GO:1900273,GO:1903078,GO:1905751" protein binding|calmodulin binding|cytosol|plasma membrane|signal transduction|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|chemical synaptic transmission|adenylate cyclase binding|cytoplasmic side of plasma membrane|regulation of protein kinase A signaling|postsynaptic density|SH3 domain binding|protein phosphatase 2B binding|beta-2 adrenergic receptor binding|dendrite membrane|protein kinase A regulatory subunit binding|glutamate receptor binding|dendritic spine|membrane raft|positive regulation of adenylate cyclase activity|GABA receptor binding|protein kinase A binding|excitatory synapse|molecular adaptor activity|scaffold protein binding|postsynaptic recycling endosome|positive regulation of long-term synaptic potentiation|positive regulation of protein localization to plasma membrane|positive regulation of endosome to plasma membrane protein transport AKAP6 16.45350772 15.60620824 17.30080721 1.108584926 0.148719296 0.942598277 1 0.053571406 0.058394668 9472 A-kinase anchoring protein 6 "GO:0001508,GO:0005515,GO:0005635,GO:0005737,GO:0005901,GO:0006605,GO:0008179,GO:0010738,GO:0010880,GO:0014701,GO:0014704,GO:0016529,GO:0019933,GO:0030307,GO:0030315,GO:0031965,GO:0034237,GO:0034704,GO:0043495,GO:0044325,GO:0048471,GO:0051018,GO:0051281,GO:0060090,GO:0060306,GO:0060316,GO:0061051,GO:0070886,GO:0071320,GO:0071345,GO:1901381,GO:1902261" action potential|protein binding|nuclear envelope|cytoplasm|caveola|protein targeting|adenylate cyclase binding|regulation of protein kinase A signaling|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|junctional sarcoplasmic reticulum membrane|intercalated disc|sarcoplasmic reticulum|cAMP-mediated signaling|positive regulation of cell growth|T-tubule|nuclear membrane|protein kinase A regulatory subunit binding|calcium channel complex|protein-membrane adaptor activity|ion channel binding|perinuclear region of cytoplasm|protein kinase A binding|positive regulation of release of sequestered calcium ion into cytosol|molecular adaptor activity|regulation of membrane repolarization|positive regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of cell growth involved in cardiac muscle cell development|positive regulation of calcineurin-NFAT signaling cascade|cellular response to cAMP|cellular response to cytokine stimulus|positive regulation of potassium ion transmembrane transport|positive regulation of delayed rectifier potassium channel activity AKAP7 152.1639671 146.6983575 157.6295768 1.07451494 0.103685542 0.811632211 1 1.419844345 1.500114376 9465 A-kinase anchoring protein 7 "GO:0000166,GO:0005515,GO:0005634,GO:0005829,GO:0008150,GO:0010738,GO:0032991,GO:0034237,GO:0051018" nucleotide binding|protein binding|nucleus|cytosol|biological_process|regulation of protein kinase A signaling|protein-containing complex|protein kinase A regulatory subunit binding|protein kinase A binding AKAP8 534.9097857 530.6110801 539.2084913 1.016202849 0.023188414 0.938806806 1 7.726531549 7.720335415 10270 A-kinase anchoring protein 8 "GO:0000278,GO:0000793,GO:0001939,GO:0003690,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005739,GO:0005794,GO:0007076,GO:0007165,GO:0008270,GO:0015031,GO:0016020,GO:0016363,GO:0031065,GO:0032720,GO:0033127,GO:0034237,GO:0042826,GO:0044839,GO:0045087,GO:0051059,GO:0071222,GO:0071380" mitotic cell cycle|condensed chromosome|female pronucleus|double-stranded DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|mitochondrion|Golgi apparatus|mitotic chromosome condensation|signal transduction|zinc ion binding|protein transport|membrane|nuclear matrix|positive regulation of histone deacetylation|negative regulation of tumor necrosis factor production|regulation of histone phosphorylation|protein kinase A regulatory subunit binding|histone deacetylase binding|cell cycle G2/M phase transition|innate immune response|NF-kappaB binding|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus AKAP8L 812.4744226 752.2192372 872.729608 1.160206446 0.21438154 0.394501545 1 19.31884416 22.03878215 26993 A-kinase anchoring protein 8 like "GO:0000785,GO:0003677,GO:0003723,GO:0005515,GO:0005521,GO:0005634,GO:0005737,GO:0006397,GO:0007076,GO:0008380,GO:0010793,GO:0016032,GO:0016363,GO:0016605,GO:0016607,GO:0017151,GO:0031065,GO:0033127,GO:0034237,GO:0042826,GO:0044839,GO:0045944,GO:0046872,GO:0051081,GO:1990904" chromatin|DNA binding|RNA binding|protein binding|lamin binding|nucleus|cytoplasm|mRNA processing|mitotic chromosome condensation|RNA splicing|regulation of mRNA export from nucleus|viral process|nuclear matrix|PML body|nuclear speck|DEAD/H-box RNA helicase binding|positive regulation of histone deacetylation|regulation of histone phosphorylation|protein kinase A regulatory subunit binding|histone deacetylase binding|cell cycle G2/M phase transition|positive regulation of transcription by RNA polymerase II|metal ion binding|nuclear envelope disassembly|ribonucleoprotein complex AKAP9 1124.896726 1232.890451 1016.903001 0.824812132 -0.277862542 0.253689603 1 3.767368875 3.0553739 10142 A-kinase anchoring protein 9 "GO:0000086,GO:0003677,GO:0005102,GO:0005515,GO:0005794,GO:0005795,GO:0005801,GO:0005813,GO:0005829,GO:0005856,GO:0007020,GO:0007165,GO:0007268,GO:0008076,GO:0010389,GO:0015459,GO:0031116,GO:0033138,GO:0034237,GO:0043231,GO:0044325,GO:0051661,GO:0060090,GO:0060306,GO:0060307,GO:0061337,GO:0071320,GO:0086091,GO:0097060,GO:0097711,GO:0098909,GO:0098962,GO:0098978,GO:1901018,GO:1903358" G2/M transition of mitotic cell cycle|DNA binding|signaling receptor binding|protein binding|Golgi apparatus|Golgi stack|cis-Golgi network|centrosome|cytosol|cytoskeleton|microtubule nucleation|signal transduction|chemical synaptic transmission|voltage-gated potassium channel complex|regulation of G2/M transition of mitotic cell cycle|potassium channel regulator activity|positive regulation of microtubule polymerization|positive regulation of peptidyl-serine phosphorylation|protein kinase A regulatory subunit binding|intracellular membrane-bounded organelle|ion channel binding|maintenance of centrosome location|molecular adaptor activity|regulation of membrane repolarization|regulation of ventricular cardiac muscle cell membrane repolarization|cardiac conduction|cellular response to cAMP|regulation of heart rate by cardiac conduction|synaptic membrane|ciliary basal body-plasma membrane docking|regulation of cardiac muscle cell action potential involved in regulation of contraction|regulation of postsynaptic neurotransmitter receptor activity|glutamatergic synapse|positive regulation of potassium ion transmembrane transporter activity|regulation of Golgi organization AKIP1 674.5988471 627.3695712 721.828123 1.150562852 0.202339796 0.43401167 1 24.89335387 28.16209371 56672 A-kinase interacting protein 1 "GO:0005515,GO:0005654,GO:0034446,GO:1901222" protein binding|nucleoplasm|substrate adhesion-dependent cell spreading|regulation of NIK/NF-kappaB signaling AKIRIN1 1598.973097 1465.943161 1732.003033 1.181493989 0.24061229 0.312271075 1 29.10516823 33.81215171 79647 akirin 1 "GO:0001228,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0010592,GO:0010759,GO:0014839,GO:0031965,GO:0045663,GO:0045944,GO:1902723,GO:1902725" "DNA-binding transcription activator activity, RNA polymerase II-specific|transcription coregulator activity|protein binding|nucleus|nucleoplasm|positive regulation of lamellipodium assembly|positive regulation of macrophage chemotaxis|myoblast migration involved in skeletal muscle regeneration|nuclear membrane|positive regulation of myoblast differentiation|positive regulation of transcription by RNA polymerase II|negative regulation of skeletal muscle satellite cell proliferation|negative regulation of satellite cell differentiation" AKIRIN2 581.7139336 560.7830827 602.6447844 1.074648653 0.10386506 0.699203916 1 15.76815724 16.66167348 55122 akirin 2 "GO:0000122,GO:0001228,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0008284,GO:0009792,GO:0010950,GO:0017053,GO:0019899,GO:0032496,GO:0032755,GO:0042802,GO:0045087,GO:0045089,GO:0045944" "negative regulation of transcription by RNA polymerase II|DNA-binding transcription activator activity, RNA polymerase II-specific|transcription coregulator activity|protein binding|nucleus|nucleoplasm|positive regulation of cell population proliferation|embryo development ending in birth or egg hatching|positive regulation of endopeptidase activity|transcription repressor complex|enzyme binding|response to lipopolysaccharide|positive regulation of interleukin-6 production|identical protein binding|innate immune response|positive regulation of innate immune response|positive regulation of transcription by RNA polymerase II" AKNA 288.0423888 357.9023756 218.182402 0.609614288 -0.714031377 0.025588174 0.86539048 2.168796638 1.300005374 80709 AT-hook transcription factor "GO:0001650,GO:0001837,GO:0003677,GO:0005515,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0005874,GO:0016020,GO:0021849,GO:0043231,GO:0045944,GO:0050727,GO:0060232,GO:0060234" fibrillar center|epithelial to mesenchymal transition|DNA binding|protein binding|nucleoplasm|centrosome|centriole|cytosol|microtubule|membrane|neuroblast division in subventricular zone|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|regulation of inflammatory response|delamination|neuroblast delamination AKNAD1 15.01177379 15.60620824 14.41733934 0.923820772 -0.11431511 0.982892021 1 0.273073656 0.2480497 254268 AKNA domain containing 1 AKR1A1 1496.77795 1546.05503 1447.50087 0.93625443 -0.095027456 0.692301099 1 52.15557231 48.01376686 10327 aldo-keto reductase family 1 member A1 "GO:0004032,GO:0004033,GO:0004745,GO:0005515,GO:0005615,GO:0005829,GO:0006006,GO:0006081,GO:0009055,GO:0016324,GO:0019640,GO:0019853,GO:0022900,GO:0042840,GO:0044597,GO:0044598,GO:0045202,GO:0046185,GO:0047655,GO:0047939,GO:0047941,GO:0070062,GO:0110095,GO:1901687" alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity|retinol dehydrogenase activity|protein binding|extracellular space|cytosol|glucose metabolic process|cellular aldehyde metabolic process|electron transfer activity|apical plasma membrane|glucuronate catabolic process to xylulose 5-phosphate|L-ascorbic acid biosynthetic process|electron transport chain|D-glucuronate catabolic process|daunorubicin metabolic process|doxorubicin metabolic process|synapse|aldehyde catabolic process|allyl-alcohol dehydrogenase activity|L-glucuronate reductase activity|glucuronolactone reductase activity|extracellular exosome|cellular detoxification of aldehyde|glutathione derivative biosynthetic process "hsa00010,hsa00040,hsa00053,hsa00561" Glycolysis / Gluconeogenesis|Pentose and glucuronate interconversions|Ascorbate and aldarate metabolism|Glycerolipid metabolism AKR1B1 7936.437762 9013.105465 6859.770058 0.761088404 -0.393864055 0.110444823 1 323.9143928 242.4021847 231 aldo-keto reductase family 1 member B "GO:0001523,GO:0001758,GO:0001894,GO:0002070,GO:0003091,GO:0004032,GO:0005515,GO:0005615,GO:0005654,GO:0005829,GO:0005975,GO:0006061,GO:0006700,GO:0009055,GO:0009414,GO:0018931,GO:0022900,GO:0031098,GO:0032838,GO:0033010,GO:0035809,GO:0042415,GO:0042572,GO:0042629,GO:0043066,GO:0043220,GO:0043795,GO:0044597,GO:0044598,GO:0046370,GO:0046427,GO:0047655,GO:0048471,GO:0048661,GO:0052650,GO:0055114,GO:0060135,GO:0070062,GO:0071475,GO:0072061,GO:0072205,GO:0097066,GO:0097238,GO:0097454,GO:1901653" retinoid metabolic process|retinal dehydrogenase activity|tissue homeostasis|epithelial cell maturation|renal water homeostasis|alditol:NADP+ 1-oxidoreductase activity|protein binding|extracellular space|nucleoplasm|cytosol|carbohydrate metabolic process|sorbitol biosynthetic process|C21-steroid hormone biosynthetic process|electron transfer activity|response to water deprivation|naphthalene metabolic process|electron transport chain|stress-activated protein kinase signaling cascade|plasma membrane bounded cell projection cytoplasm|paranodal junction|regulation of urine volume|norepinephrine metabolic process|retinol metabolic process|mast cell granule|negative regulation of apoptotic process|Schmidt-Lanterman incisure|glyceraldehyde oxidoreductase activity|daunorubicin metabolic process|doxorubicin metabolic process|fructose biosynthetic process|positive regulation of receptor signaling pathway via JAK-STAT|allyl-alcohol dehydrogenase activity|perinuclear region of cytoplasm|positive regulation of smooth muscle cell proliferation|NADP-retinol dehydrogenase activity|oxidation-reduction process|maternal process involved in female pregnancy|extracellular exosome|cellular hyperosmotic salinity response|inner medullary collecting duct development|metanephric collecting duct development|response to thyroid hormone|cellular response to methylglyoxal|Schwann cell microvillus|cellular response to peptide "hsa00040,hsa00051,hsa00052,hsa00561,hsa00790" Pentose and glucuronate interconversions|Fructose and mannose metabolism|Galactose metabolism|Glycerolipid metabolism|Folate biosynthesis AKR1B10 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.063072673 0 57016 aldo-keto reductase family 1 member B10 "GO:0001523,GO:0001758,GO:0004032,GO:0004033,GO:0005515,GO:0005576,GO:0005739,GO:0005764,GO:0005829,GO:0008106,GO:0016488,GO:0042572,GO:0044597,GO:0044598,GO:0045550,GO:0047655,GO:0047718,GO:0052650,GO:0055114,GO:0110095" retinoid metabolic process|retinal dehydrogenase activity|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity|protein binding|extracellular region|mitochondrion|lysosome|cytosol|alcohol dehydrogenase (NADP+) activity|farnesol catabolic process|retinol metabolic process|daunorubicin metabolic process|doxorubicin metabolic process|geranylgeranyl reductase activity|allyl-alcohol dehydrogenase activity|indanol dehydrogenase activity|NADP-retinol dehydrogenase activity|oxidation-reduction process|cellular detoxification of aldehyde "hsa00040,hsa00051,hsa00052,hsa00561,hsa00790" Pentose and glucuronate interconversions|Fructose and mannose metabolism|Galactose metabolism|Glycerolipid metabolism|Folate biosynthesis AKR1C1 728.6953386 748.0575816 709.3330955 0.948233282 -0.076686064 0.767686278 1 12.37138465 11.53465696 1645 aldo-keto reductase family 1 member C1 "GO:0001523,GO:0004032,GO:0004033,GO:0004303,GO:0005515,GO:0005829,GO:0006693,GO:0006805,GO:0007586,GO:0008202,GO:0008206,GO:0015721,GO:0016229,GO:0016655,GO:0018636,GO:0030283,GO:0030299,GO:0030855,GO:0031406,GO:0032052,GO:0035410,GO:0042448,GO:0042574,GO:0042632,GO:0044597,GO:0044598,GO:0046683,GO:0047006,GO:0047023,GO:0047024,GO:0047042,GO:0047044,GO:0047086,GO:0047115,GO:0047718,GO:0055114,GO:0070062,GO:0071395" "retinoid metabolic process|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity|estradiol 17-beta-dehydrogenase activity|protein binding|cytosol|prostaglandin metabolic process|xenobiotic metabolic process|digestion|steroid metabolic process|bile acid metabolic process|bile acid and bile salt transport|steroid dehydrogenase activity|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|phenanthrene 9,10-monooxygenase activity|testosterone dehydrogenase [NAD(P)] activity|intestinal cholesterol absorption|epithelial cell differentiation|carboxylic acid binding|bile acid binding|dihydrotestosterone 17-beta-dehydrogenase activity|progesterone metabolic process|retinal metabolic process|cholesterol homeostasis|daunorubicin metabolic process|doxorubicin metabolic process|response to organophosphorus|17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|androsterone dehydrogenase activity|5alpha-androstane-3beta,17beta-diol dehydrogenase activity|androsterone dehydrogenase (B-specific) activity|androstan-3-alpha,17-beta-diol dehydrogenase activity|ketosteroid monooxygenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity|indanol dehydrogenase activity|oxidation-reduction process|extracellular exosome|cellular response to jasmonic acid stimulus" "hsa00140,hsa00980" Steroid hormone biosynthesis|Metabolism of xenobiotics by cytochrome P450 AKR1C2 16.28996145 23.9295193 8.650403604 0.361495085 -1.467952065 0.117433253 1 0.322005664 0.114455611 1646 aldo-keto reductase family 1 member C2 "GO:0004032,GO:0004303,GO:0005829,GO:0006693,GO:0007186,GO:0007586,GO:0008202,GO:0008284,GO:0016229,GO:0016655,GO:0018636,GO:0030855,GO:0031406,GO:0032052,GO:0042448,GO:0044597,GO:0044598,GO:0047023,GO:0047044,GO:0047086,GO:0047115,GO:0047718,GO:0051897,GO:0055114,GO:0071395,GO:0071799" "alditol:NADP+ 1-oxidoreductase activity|estradiol 17-beta-dehydrogenase activity|cytosol|prostaglandin metabolic process|G protein-coupled receptor signaling pathway|digestion|steroid metabolic process|positive regulation of cell population proliferation|steroid dehydrogenase activity|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|phenanthrene 9,10-monooxygenase activity|epithelial cell differentiation|carboxylic acid binding|bile acid binding|progesterone metabolic process|daunorubicin metabolic process|doxorubicin metabolic process|androsterone dehydrogenase activity|androstan-3-alpha,17-beta-diol dehydrogenase activity|ketosteroid monooxygenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity|indanol dehydrogenase activity|positive regulation of protein kinase B signaling|oxidation-reduction process|cellular response to jasmonic acid stimulus|cellular response to prostaglandin D stimulus" "hsa00140,hsa05204" Steroid hormone biosynthesis|Chemical carcinogenesis AKR1C3 273.0557671 279.8713344 266.2401998 0.951294995 -0.072035306 0.835068049 1 7.751021659 7.250122441 8644 aldo-keto reductase family 1 member C3 "GO:0001523,GO:0001758,GO:0004032,GO:0004033,GO:0004303,GO:0004745,GO:0005634,GO:0005737,GO:0005829,GO:0006693,GO:0007186,GO:0007584,GO:0008202,GO:0008284,GO:0008584,GO:0009267,GO:0010942,GO:0016229,GO:0016488,GO:0016655,GO:0018636,GO:0019371,GO:0030216,GO:0032052,GO:0034614,GO:0035410,GO:0036130,GO:0036131,GO:0042448,GO:0042572,GO:0042574,GO:0043170,GO:0044597,GO:0044598,GO:0045550,GO:0045703,GO:0047017,GO:0047020,GO:0047023,GO:0047024,GO:0047035,GO:0047044,GO:0047045,GO:0047086,GO:0047787,GO:0048385,GO:0051897,GO:0052650,GO:0055114,GO:0061370,GO:0070062,GO:0070293,GO:0071276,GO:0071277,GO:0071379,GO:0071384,GO:0071395,GO:0071799,GO:1900053,GO:2000224,GO:2000353,GO:2000379" "retinoid metabolic process|retinal dehydrogenase activity|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity|estradiol 17-beta-dehydrogenase activity|retinol dehydrogenase activity|nucleus|cytoplasm|cytosol|prostaglandin metabolic process|G protein-coupled receptor signaling pathway|response to nutrient|steroid metabolic process|positive regulation of cell population proliferation|male gonad development|cellular response to starvation|positive regulation of cell death|steroid dehydrogenase activity|farnesol catabolic process|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|phenanthrene 9,10-monooxygenase activity|cyclooxygenase pathway|keratinocyte differentiation|bile acid binding|cellular response to reactive oxygen species|dihydrotestosterone 17-beta-dehydrogenase activity|prostaglandin H2 endoperoxidase reductase activity|prostaglandin D2 11-ketoreductase activity|progesterone metabolic process|retinol metabolic process|retinal metabolic process|macromolecule metabolic process|daunorubicin metabolic process|doxorubicin metabolic process|geranylgeranyl reductase activity|ketoreductase activity|prostaglandin-F synthase activity|15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity|androsterone dehydrogenase activity|5alpha-androstane-3beta,17beta-diol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity|androstan-3-alpha,17-beta-diol dehydrogenase activity|testosterone 17-beta-dehydrogenase (NADP+) activity|ketosteroid monooxygenase activity|delta4-3-oxosteroid 5beta-reductase activity|regulation of retinoic acid receptor signaling pathway|positive regulation of protein kinase B signaling|NADP-retinol dehydrogenase activity|oxidation-reduction process|testosterone biosynthetic process|extracellular exosome|renal absorption|cellular response to cadmium ion|cellular response to calcium ion|cellular response to prostaglandin stimulus|cellular response to corticosteroid stimulus|cellular response to jasmonic acid stimulus|cellular response to prostaglandin D stimulus|negative regulation of retinoic acid biosynthetic process|regulation of testosterone biosynthetic process|positive regulation of endothelial cell apoptotic process|positive regulation of reactive oxygen species metabolic process" "hsa00140,hsa00590,hsa00790,hsa04913" Steroid hormone biosynthesis|Arachidonic acid metabolism|Folate biosynthesis|Ovarian steroidogenesis AKR7A2 582.7939764 563.9043244 601.6836285 1.066995947 0.093554696 0.728403559 1 11.49963217 12.06473806 8574 aldo-keto reductase family 7 member A2 "GO:0004032,GO:0005515,GO:0005794,GO:0005829,GO:0005975,GO:0006081,GO:0006805,GO:0009055,GO:0019119,GO:0022900,GO:0044597,GO:0044598,GO:0070062" "alditol:NADP+ 1-oxidoreductase activity|protein binding|Golgi apparatus|cytosol|carbohydrate metabolic process|cellular aldehyde metabolic process|xenobiotic metabolic process|electron transfer activity|phenanthrene-9,10-epoxide hydrolase activity|electron transport chain|daunorubicin metabolic process|doxorubicin metabolic process|extracellular exosome" hsa00980 Metabolism of xenobiotics by cytochrome P450 AKR7A3 9.928591267 8.323311061 11.53387147 1.385731158 0.470647391 0.750315201 1 0.269538722 0.367258051 22977 aldo-keto reductase family 7 member A3 "GO:0004033,GO:0005515,GO:0005829,GO:0006081,GO:0006805,GO:0009055,GO:0022900,GO:0042802,GO:0046223,GO:0070062" aldo-keto reductase (NADP) activity|protein binding|cytosol|cellular aldehyde metabolic process|xenobiotic metabolic process|electron transfer activity|electron transport chain|identical protein binding|aflatoxin catabolic process|extracellular exosome hsa00980 Metabolism of xenobiotics by cytochrome P450 AKT1 4480.613348 3815.197708 5146.028988 1.348823674 0.431701763 0.071157542 1 59.93820713 79.4932232 207 AKT serine/threonine kinase 1 "GO:0001649,GO:0001893,GO:0001934,GO:0001938,GO:0002042,GO:0003376,GO:0004672,GO:0004674,GO:0004712,GO:0005080,GO:0005515,GO:0005516,GO:0005524,GO:0005547,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005819,GO:0005829,GO:0005886,GO:0005911,GO:0005978,GO:0005979,GO:0006006,GO:0006412,GO:0006417,GO:0006468,GO:0006469,GO:0006606,GO:0006809,GO:0006924,GO:0006954,GO:0006974,GO:0006979,GO:0007165,GO:0007173,GO:0007186,GO:0007249,GO:0007281,GO:0007568,GO:0008283,GO:0008284,GO:0008286,GO:0008637,GO:0008643,GO:0009408,GO:0010507,GO:0010595,GO:0010628,GO:0010629,GO:0010748,GO:0010761,GO:0010763,GO:0010765,GO:0010907,GO:0010918,GO:0010951,GO:0010975,GO:0014065,GO:0015630,GO:0016242,GO:0016301,GO:0016310,GO:0016567,GO:0018105,GO:0018107,GO:0019221,GO:0019899,GO:0021510,GO:0030027,GO:0030030,GO:0030154,GO:0030163,GO:0030212,GO:0030235,GO:0030307,GO:0030334,GO:0031018,GO:0031234,GO:0031295,GO:0031397,GO:0031641,GO:0031663,GO:0031929,GO:0031982,GO:0031999,GO:0032079,GO:0032091,GO:0032094,GO:0032148,GO:0032270,GO:0032287,GO:0032436,GO:0032794,GO:0032869,GO:0032991,GO:0033138,GO:0034405,GO:0034614,GO:0035556,GO:0035655,GO:0035924,GO:0036064,GO:0038061,GO:0042593,GO:0042802,GO:0042803,GO:0042981,GO:0043065,GO:0043066,GO:0043154,GO:0043276,GO:0043325,GO:0043488,GO:0043491,GO:0043536,GO:0045429,GO:0045600,GO:0045725,GO:0045737,GO:0045742,GO:0045746,GO:0045792,GO:0045861,GO:0045893,GO:0045907,GO:0045944,GO:0046326,GO:0046329,GO:0046622,GO:0046777,GO:0046889,GO:0048009,GO:0048661,GO:0050999,GO:0051000,GO:0051091,GO:0051146,GO:0051721,GO:0051898,GO:0060079,GO:0060416,GO:0060644,GO:0060716,GO:0070141,GO:0071260,GO:0071276,GO:0071356,GO:0071364,GO:0071380,GO:0071407,GO:0071456,GO:0071889,GO:0071901,GO:0072655,GO:0072656,GO:0090201,GO:0097011,GO:0097194,GO:0098794,GO:0100002,GO:0106310,GO:0106311,GO:0140052,GO:1900087,GO:1900182,GO:1901215,GO:1901796,GO:1902176,GO:1903038,GO:1903078,GO:1903721,GO:1990090,GO:1990418,GO:2000010,GO:2000402,GO:2001240" "osteoblast differentiation|maternal placenta development|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|cell migration involved in sprouting angiogenesis|sphingosine-1-phosphate receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein kinase C binding|protein binding|calmodulin binding|ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|spindle|cytosol|plasma membrane|cell-cell junction|glycogen biosynthetic process|regulation of glycogen biosynthetic process|glucose metabolic process|translation|regulation of translation|protein phosphorylation|negative regulation of protein kinase activity|protein import into nucleus|nitric oxide biosynthetic process|activation-induced cell death of T cells|inflammatory response|cellular response to DNA damage stimulus|response to oxidative stress|signal transduction|epidermal growth factor receptor signaling pathway|G protein-coupled receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|germ cell development|aging|cell population proliferation|positive regulation of cell population proliferation|insulin receptor signaling pathway|apoptotic mitochondrial changes|carbohydrate transport|response to heat|negative regulation of autophagy|positive regulation of endothelial cell migration|positive regulation of gene expression|negative regulation of gene expression|negative regulation of long-chain fatty acid import across plasma membrane|fibroblast migration|positive regulation of fibroblast migration|positive regulation of sodium ion transport|positive regulation of glucose metabolic process|positive regulation of mitochondrial membrane potential|negative regulation of endopeptidase activity|regulation of neuron projection development|phosphatidylinositol 3-kinase signaling|microtubule cytoskeleton|negative regulation of macroautophagy|kinase activity|phosphorylation|protein ubiquitination|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|cytokine-mediated signaling pathway|enzyme binding|spinal cord development|lamellipodium|cell projection organization|cell differentiation|protein catabolic process|hyaluronan metabolic process|nitric-oxide synthase regulator activity|positive regulation of cell growth|regulation of cell migration|endocrine pancreas development|extrinsic component of cytoplasmic side of plasma membrane|T cell costimulation|negative regulation of protein ubiquitination|regulation of myelination|lipopolysaccharide-mediated signaling pathway|TOR signaling|vesicle|negative regulation of fatty acid beta-oxidation|positive regulation of endodeoxyribonuclease activity|negative regulation of protein binding|response to food|activation of protein kinase B activity|positive regulation of cellular protein metabolic process|peripheral nervous system myelin maintenance|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|GTPase activating protein binding|cellular response to insulin stimulus|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|response to fluid shear stress|cellular response to reactive oxygen species|intracellular signal transduction|interleukin-18-mediated signaling pathway|cellular response to vascular endothelial growth factor stimulus|ciliary basal body|NIK/NF-kappaB signaling|glucose homeostasis|identical protein binding|protein homodimerization activity|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|anoikis|phosphatidylinositol-3,4-bisphosphate binding|regulation of mRNA stability|protein kinase B signaling|positive regulation of blood vessel endothelial cell migration|positive regulation of nitric oxide biosynthetic process|positive regulation of fat cell differentiation|positive regulation of glycogen biosynthetic process|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of epidermal growth factor receptor signaling pathway|negative regulation of Notch signaling pathway|negative regulation of cell size|negative regulation of proteolysis|positive regulation of transcription, DNA-templated|positive regulation of vasoconstriction|positive regulation of transcription by RNA polymerase II|positive regulation of glucose import|negative regulation of JNK cascade|positive regulation of organ growth|protein autophosphorylation|positive regulation of lipid biosynthetic process|insulin-like growth factor receptor signaling pathway|positive regulation of smooth muscle cell proliferation|regulation of nitric-oxide synthase activity|positive regulation of nitric-oxide synthase activity|positive regulation of DNA-binding transcription factor activity|striated muscle cell differentiation|protein phosphatase 2A binding|negative regulation of protein kinase B signaling|excitatory postsynaptic potential|response to growth hormone|mammary gland epithelial cell differentiation|labyrinthine layer blood vessel development|response to UV-A|cellular response to mechanical stimulus|cellular response to cadmium ion|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|cellular response to prostaglandin E stimulus|cellular response to organic cyclic compound|cellular response to hypoxia|14-3-3 protein binding|negative regulation of protein serine/threonine kinase activity|establishment of protein localization to mitochondrion|maintenance of protein location in mitochondrion|negative regulation of release of cytochrome c from mitochondria|cellular response to granulocyte macrophage colony-stimulating factor stimulus|execution phase of apoptosis|postsynapse|negative regulation of protein kinase activity by protein phosphorylation|protein serine kinase activity|protein threonine kinase activity|cellular response to oxidised low-density lipoprotein particle stimulus|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of protein localization to nucleus|negative regulation of neuron death|regulation of signal transduction by p53 class mediator|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|negative regulation of leukocyte cell-cell adhesion|positive regulation of protein localization to plasma membrane|positive regulation of I-kappaB phosphorylation|cellular response to nerve growth factor stimulus|response to insulin-like growth factor stimulus|positive regulation of protein localization to cell surface|negative regulation of lymphocyte migration|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa01521,hsa01522,hsa01524,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04066,hsa04068,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04261,hsa04370,hsa04371,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04722,hsa04725,hsa04728,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04920,hsa04922,hsa04923,hsa04926,hsa04929,hsa04931,hsa04932,hsa04933,hsa04935,hsa04973,hsa05010,hsa05017,hsa05131,hsa05132,hsa05135,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235,hsa05418" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|GnRH secretion|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Carbohydrate digestion and absorption|Alzheimer disease|Spinocerebellar ataxia|Shigellosis|Salmonella infection|Yersinia infection|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" AKT1S1 538.8286371 545.1768745 532.4803996 0.976711274 -0.033995945 0.90639397 1 9.666142126 9.283047139 84335 AKT1 substrate 1 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006469,GO:0031931,GO:0032007,GO:0042981,GO:0043523,GO:0045792,GO:0048011,GO:1900034" protein binding|nucleoplasm|cytoplasm|cytosol|negative regulation of protein kinase activity|TORC1 complex|negative regulation of TOR signaling|regulation of apoptotic process|regulation of neuron apoptotic process|negative regulation of cell size|neurotrophin TRK receptor signaling pathway|regulation of cellular response to heat "hsa04140,hsa04150,hsa04152,hsa04211,hsa04213,hsa04714,hsa05131" Autophagy - animal|mTOR signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Thermogenesis|Shigellosis AKT2 1321.962651 1359.820945 1284.104357 0.944318708 -0.082654243 0.733221327 1 8.537781714 7.927473868 208 AKT serine/threonine kinase 2 "GO:0001934,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005769,GO:0005829,GO:0005886,GO:0005938,GO:0005978,GO:0006006,GO:0006417,GO:0006464,GO:0007165,GO:0008284,GO:0008286,GO:0008643,GO:0010748,GO:0010907,GO:0010918,GO:0018105,GO:0030334,GO:0030335,GO:0031340,GO:0032000,GO:0032287,GO:0032587,GO:0032869,GO:0032991,GO:0035556,GO:0043066,GO:0043231,GO:0045444,GO:0045725,GO:0046326,GO:0046872,GO:0060644,GO:0065002,GO:0071156,GO:0071486,GO:0072659,GO:0090314,GO:0090630,GO:0097473,GO:0106310,GO:0106311,GO:2000147" positive regulation of protein phosphorylation|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|early endosome|cytosol|plasma membrane|cell cortex|glycogen biosynthetic process|glucose metabolic process|regulation of translation|cellular protein modification process|signal transduction|positive regulation of cell population proliferation|insulin receptor signaling pathway|carbohydrate transport|negative regulation of long-chain fatty acid import across plasma membrane|positive regulation of glucose metabolic process|positive regulation of mitochondrial membrane potential|peptidyl-serine phosphorylation|regulation of cell migration|positive regulation of cell migration|positive regulation of vesicle fusion|positive regulation of fatty acid beta-oxidation|peripheral nervous system myelin maintenance|ruffle membrane|cellular response to insulin stimulus|protein-containing complex|intracellular signal transduction|negative regulation of apoptotic process|intracellular membrane-bounded organelle|fat cell differentiation|positive regulation of glycogen biosynthetic process|positive regulation of glucose import|metal ion binding|mammary gland epithelial cell differentiation|intracellular protein transmembrane transport|regulation of cell cycle arrest|cellular response to high light intensity|protein localization to plasma membrane|positive regulation of protein targeting to membrane|activation of GTPase activity|retinal rod cell apoptotic process|protein serine kinase activity|protein threonine kinase activity|positive regulation of cell motility "hsa01521,hsa01522,hsa01524,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04066,hsa04068,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04261,hsa04370,hsa04371,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04722,hsa04725,hsa04728,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04920,hsa04922,hsa04923,hsa04926,hsa04929,hsa04931,hsa04932,hsa04933,hsa04935,hsa04973,hsa05010,hsa05017,hsa05131,hsa05132,hsa05135,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235,hsa05418" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|GnRH secretion|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Carbohydrate digestion and absorption|Alzheimer disease|Spinocerebellar ataxia|Shigellosis|Salmonella infection|Yersinia infection|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" AKT3 2988.533696 2834.087416 3142.979976 1.108991896 0.149248822 0.528820737 1 23.42056931 25.53859486 10000 AKT serine/threonine kinase 3 "GO:0000002,GO:0001938,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0007165,GO:0016020,GO:0018105,GO:0032008,GO:0035556,GO:0043536,GO:0045766,GO:0045793,GO:0048854,GO:0048873,GO:0090050,GO:0106310,GO:0106311,GO:1905564,GO:1905653,GO:2000773" mitochondrial genome maintenance|positive regulation of endothelial cell proliferation|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|signal transduction|membrane|peptidyl-serine phosphorylation|positive regulation of TOR signaling|intracellular signal transduction|positive regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of cell size|brain morphogenesis|homeostasis of number of cells within a tissue|positive regulation of cell migration involved in sprouting angiogenesis|protein serine kinase activity|protein threonine kinase activity|positive regulation of vascular endothelial cell proliferation|positive regulation of artery morphogenesis|negative regulation of cellular senescence "hsa01521,hsa01522,hsa01524,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04066,hsa04068,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04261,hsa04370,hsa04371,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04722,hsa04725,hsa04728,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04920,hsa04922,hsa04923,hsa04926,hsa04929,hsa04931,hsa04932,hsa04933,hsa04935,hsa04973,hsa05010,hsa05017,hsa05131,hsa05132,hsa05135,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235,hsa05418" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|GnRH secretion|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Carbohydrate digestion and absorption|Alzheimer disease|Spinocerebellar ataxia|Shigellosis|Salmonella infection|Yersinia infection|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" AKTIP 509.6674802 460.90335 558.4316104 1.211602412 0.276916355 0.30989928 1 8.432487037 10.04585696 64400 AKT interacting protein "GO:0000209,GO:0001934,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0006915,GO:0006974,GO:0007032,GO:0007040,GO:0008333,GO:0015031,GO:0018215,GO:0019787,GO:0030897,GO:0032092,GO:0045022,GO:0061631,GO:0070695" protein polyubiquitination|positive regulation of protein phosphorylation|protein binding|nucleus|cytosol|plasma membrane|apoptotic process|cellular response to DNA damage stimulus|endosome organization|lysosome organization|endosome to lysosome transport|protein transport|protein phosphopantetheinylation|ubiquitin-like protein transferase activity|HOPS complex|positive regulation of protein binding|early endosome to late endosome transport|ubiquitin conjugating enzyme activity|FHF complex ALAD 1038.958785 1020.646019 1057.271552 1.035884657 0.050863372 0.839120733 1 14.67798495 14.95026936 210 aminolevulinate dehydratase "GO:0001666,GO:0003824,GO:0004655,GO:0005576,GO:0005634,GO:0005829,GO:0006782,GO:0006783,GO:0006979,GO:0008270,GO:0009635,GO:0010039,GO:0010043,GO:0010044,GO:0010212,GO:0010266,GO:0010269,GO:0014823,GO:0032025,GO:0032496,GO:0033197,GO:0034774,GO:0042493,GO:0042802,GO:0043200,GO:0043312,GO:0045471,GO:0046685,GO:0046686,GO:0046689,GO:0051260,GO:0051384,GO:0051597,GO:0070062,GO:0070541,GO:0070542,GO:0071284,GO:0071353,GO:1901799,GO:1904813,GO:1904854" response to hypoxia|catalytic activity|porphobilinogen synthase activity|extracellular region|nucleus|cytosol|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|response to oxidative stress|zinc ion binding|response to herbicide|response to iron ion|response to zinc ion|response to aluminum ion|response to ionizing radiation|response to vitamin B1|response to selenium ion|response to activity|response to cobalt ion|response to lipopolysaccharide|response to vitamin E|secretory granule lumen|response to drug|identical protein binding|response to amino acid|neutrophil degranulation|response to ethanol|response to arsenic-containing substance|response to cadmium ion|response to mercury ion|protein homooligomerization|response to glucocorticoid|response to methylmercury|extracellular exosome|response to platinum ion|response to fatty acid|cellular response to lead ion|cellular response to interleukin-4|negative regulation of proteasomal protein catabolic process|ficolin-1-rich granule lumen|proteasome core complex binding hsa00860 Porphyrin and chlorophyll metabolism ALAS1 1530.626614 1526.287166 1534.966062 1.00568628 0.008180332 0.97569731 1 33.07151476 32.7030148 211 5'-aminolevulinate synthase 1 "GO:0001666,GO:0003870,GO:0005515,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0006782,GO:0006783,GO:0007005,GO:0019216,GO:0030170,GO:0042541,GO:0042802,GO:0048821" response to hypoxia|5-aminolevulinate synthase activity|protein binding|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|mitochondrion organization|regulation of lipid metabolic process|pyridoxal phosphate binding|hemoglobin biosynthetic process|identical protein binding|erythrocyte development "hsa00260,hsa00860" "Glycine, serine and threonine metabolism|Porphyrin and chlorophyll metabolism" ALCAM 7587.858752 7621.03169 7554.685814 0.991294371 -0.012614557 0.95962421 1 65.96179929 64.29338806 214 activated leukocyte cell adhesion molecule "GO:0001772,GO:0002250,GO:0005102,GO:0005515,GO:0005887,GO:0005925,GO:0007155,GO:0007157,GO:0007165,GO:0008045,GO:0009897,GO:0030424,GO:0030425,GO:0031226,GO:0031290,GO:0042101,GO:0042802,GO:0043025,GO:0048846,GO:0070062,GO:1990138" immunological synapse|adaptive immune response|signaling receptor binding|protein binding|integral component of plasma membrane|focal adhesion|cell adhesion|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|signal transduction|motor neuron axon guidance|external side of plasma membrane|axon|dendrite|intrinsic component of plasma membrane|retinal ganglion cell axon guidance|T cell receptor complex|identical protein binding|neuronal cell body|axon extension involved in axon guidance|extracellular exosome|neuron projection extension hsa04514 Cell adhesion molecules ALDH16A1 211.646196 219.5273292 203.7650627 0.928199069 -0.107493844 0.77341587 1 3.702835047 3.379455038 126133 aldehyde dehydrogenase 16 family member A1 "GO:0005515,GO:0016020,GO:0016620,GO:0055114" "protein binding|membrane|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|oxidation-reduction process" ALDH18A1 5872.559903 5523.557303 6221.562503 1.12636878 0.171679252 0.477989864 1 80.47559416 89.12837223 5832 aldehyde dehydrogenase 18 family member A1 "GO:0003723,GO:0004349,GO:0004350,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0006536,GO:0006561,GO:0006592,GO:0008652,GO:0016310,GO:0019240,GO:0042802,GO:0055114,GO:0055129" RNA binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|glutamate metabolic process|proline biosynthetic process|ornithine biosynthetic process|cellular amino acid biosynthetic process|phosphorylation|citrulline biosynthetic process|identical protein binding|oxidation-reduction process|L-proline biosynthetic process hsa00330 Arginine and proline metabolism ALDH1A1 124.7565455 83.23311061 166.2799804 1.997762419 0.998385023 0.021767077 0.822216713 2.11927392 4.162958787 216 aldehyde dehydrogenase 1 family member A1 "GO:0001523,GO:0001758,GO:0004029,GO:0005096,GO:0005497,GO:0005515,GO:0005737,GO:0005829,GO:0006069,GO:0006081,GO:0018479,GO:0042572,GO:0043547,GO:0051287,GO:0055114,GO:0061624,GO:0070062,GO:0120163" retinoid metabolic process|retinal dehydrogenase activity|aldehyde dehydrogenase (NAD+) activity|GTPase activator activity|androgen binding|protein binding|cytoplasm|cytosol|ethanol oxidation|cellular aldehyde metabolic process|benzaldehyde dehydrogenase (NAD+) activity|retinol metabolic process|positive regulation of GTPase activity|NAD binding|oxidation-reduction process|fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate|extracellular exosome|negative regulation of cold-induced thermogenesis hsa00830 Retinol metabolism ALDH1A3 20321.71612 22672.69933 17970.73291 0.7926155 -0.335306915 0.221105906 1 348.8037742 271.8409723 220 aldehyde dehydrogenase 1 family member A3 "GO:0001758,GO:0002072,GO:0002138,GO:0004029,GO:0004030,GO:0005737,GO:0005829,GO:0007626,GO:0021768,GO:0031076,GO:0042472,GO:0042572,GO:0042573,GO:0042574,GO:0042803,GO:0043065,GO:0048048,GO:0050885,GO:0051289,GO:0055114,GO:0060013,GO:0060166,GO:0060324,GO:0070062,GO:0070324,GO:0070384,GO:0070403" retinal dehydrogenase activity|optic cup morphogenesis involved in camera-type eye development|retinoic acid biosynthetic process|aldehyde dehydrogenase (NAD+) activity|aldehyde dehydrogenase [NAD(P)+] activity|cytoplasm|cytosol|locomotory behavior|nucleus accumbens development|embryonic camera-type eye development|inner ear morphogenesis|retinol metabolic process|retinoic acid metabolic process|retinal metabolic process|protein homodimerization activity|positive regulation of apoptotic process|embryonic eye morphogenesis|neuromuscular process controlling balance|protein homotetramerization|oxidation-reduction process|righting reflex|olfactory pit development|face development|extracellular exosome|thyroid hormone binding|Harderian gland development|NAD+ binding hsa00830 Retinol metabolism ALDH1B1 781.2953759 905.1600779 657.4306739 0.726314262 -0.461334186 0.067438604 1 15.50280159 11.07148662 219 aldehyde dehydrogenase 1 family member B1 "GO:0004029,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0005975,GO:0006068,GO:0006069,GO:0043231,GO:0043878,GO:0051287" aldehyde dehydrogenase (NAD+) activity|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|carbohydrate metabolic process|ethanol catabolic process|ethanol oxidation|intracellular membrane-bounded organelle|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity|NAD binding "hsa00010,hsa00053,hsa00071,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa00561,hsa00620,hsa00770" "Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Glycerolipid metabolism|Pyruvate metabolism|Pantothenate and CoA biosynthesis" ALDH1L1 42.15688392 34.33365813 49.98010971 1.45571758 0.541730489 0.406371033 1 0.529726578 0.758228437 10840 aldehyde dehydrogenase 1 family member L1 "GO:0003824,GO:0004029,GO:0005829,GO:0006730,GO:0009058,GO:0009258,GO:0016155,GO:0016742,GO:0046655,GO:0055114,GO:0070062" "catalytic activity|aldehyde dehydrogenase (NAD+) activity|cytosol|one-carbon metabolic process|biosynthetic process|10-formyltetrahydrofolate catabolic process|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|folic acid metabolic process|oxidation-reduction process|extracellular exosome" hsa00670 One carbon pool by folate ALDH1L2 347.7919596 462.9841778 232.5997414 0.50239242 -0.993113398 0.001020963 0.197406218 3.066726404 1.514918569 160428 aldehyde dehydrogenase 1 family member L2 "GO:0004029,GO:0005515,GO:0005654,GO:0005739,GO:0005759,GO:0006730,GO:0009058,GO:0009258,GO:0016155,GO:0016742,GO:0046655,GO:0055114,GO:0070062" "aldehyde dehydrogenase (NAD+) activity|protein binding|nucleoplasm|mitochondrion|mitochondrial matrix|one-carbon metabolic process|biosynthetic process|10-formyltetrahydrofolate catabolic process|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|folic acid metabolic process|oxidation-reduction process|extracellular exosome" hsa00670 One carbon pool by folate ALDH2 534.1713123 574.3084632 494.0341614 0.860224414 -0.217215017 0.421665979 1 3.205709355 2.711484258 217 aldehyde dehydrogenase 2 family member "GO:0004029,GO:0004030,GO:0005759,GO:0005975,GO:0006066,GO:0006068,GO:0006069,GO:0009055,GO:0022900,GO:0043878,GO:0051287,GO:0070062" aldehyde dehydrogenase (NAD+) activity|aldehyde dehydrogenase [NAD(P)+] activity|mitochondrial matrix|carbohydrate metabolic process|alcohol metabolic process|ethanol catabolic process|ethanol oxidation|electron transfer activity|electron transport chain|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity|NAD binding|extracellular exosome "hsa00010,hsa00053,hsa00071,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa00561,hsa00620,hsa00770" "Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Glycerolipid metabolism|Pyruvate metabolism|Pantothenate and CoA biosynthesis" ALDH3A2 1184.136765 1211.041759 1157.231771 0.95556719 -0.065570776 0.789602187 1 16.25530002 15.27310712 224 aldehyde dehydrogenase 3 family member A2 "GO:0001561,GO:0004028,GO:0004029,GO:0005515,GO:0005778,GO:0005789,GO:0006081,GO:0007417,GO:0007422,GO:0008544,GO:0016021,GO:0030148,GO:0033306,GO:0042803,GO:0043231,GO:0043878,GO:0046458,GO:0046577,GO:0050061,GO:0052814,GO:0055114" fatty acid alpha-oxidation|3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD+) activity|protein binding|peroxisomal membrane|endoplasmic reticulum membrane|cellular aldehyde metabolic process|central nervous system development|peripheral nervous system development|epidermis development|integral component of membrane|sphingolipid biosynthetic process|phytol metabolic process|protein homodimerization activity|intracellular membrane-bounded organelle|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity|hexadecanal metabolic process|long-chain-alcohol oxidase activity|long-chain-aldehyde dehydrogenase activity|medium-chain-aldehyde dehydrogenase activity|oxidation-reduction process "hsa00010,hsa00053,hsa00071,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa00561,hsa00620,hsa00770" "Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Glycerolipid metabolism|Pyruvate metabolism|Pantothenate and CoA biosynthesis" ALDH3B1 510.2613003 577.4297049 443.0928957 0.76735383 -0.382036131 0.160095097 1 10.42149546 7.863155921 221 aldehyde dehydrogenase 3 family member B1 "GO:0004028,GO:0004030,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006068,GO:0006629,GO:0018477,GO:0018479,GO:0030148,GO:0030667,GO:0031982,GO:0034599,GO:0035579,GO:0043312,GO:0046185,GO:0055114,GO:0070062" 3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase [NAD(P)+] activity|protein binding|cytoplasm|cytosol|plasma membrane|alcohol metabolic process|ethanol catabolic process|lipid metabolic process|benzaldehyde dehydrogenase (NADP+) activity|benzaldehyde dehydrogenase (NAD+) activity|sphingolipid biosynthetic process|secretory granule membrane|vesicle|cellular response to oxidative stress|specific granule membrane|neutrophil degranulation|aldehyde catabolic process|oxidation-reduction process|extracellular exosome "hsa00010,hsa00340,hsa00350,hsa00360,hsa00410,hsa00980,hsa00982,hsa05204" Glycolysis / Gluconeogenesis|Histidine metabolism|Tyrosine metabolism|Phenylalanine metabolism|beta-Alanine metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Chemical carcinogenesis ALDH4A1 205.0420216 210.1636043 199.9204388 0.951260993 -0.072086875 0.854088418 1 3.361116361 3.143796419 8659 aldehyde dehydrogenase 4 family member A1 "GO:0003842,GO:0004029,GO:0005515,GO:0005739,GO:0005759,GO:0005829,GO:0006560,GO:0006562,GO:0009055,GO:0010133,GO:0019470,GO:0022900,GO:0042802,GO:0046487" 1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD+) activity|protein binding|mitochondrion|mitochondrial matrix|cytosol|proline metabolic process|proline catabolic process|electron transfer activity|proline catabolic process to glutamate|4-hydroxyproline catabolic process|electron transport chain|identical protein binding|glyoxylate metabolic process "hsa00250,hsa00330" "Alanine, aspartate and glutamate metabolism|Arginine and proline metabolism" ALDH5A1 74.18200134 67.62690237 80.7371003 1.19386069 0.2556345 0.638814285 1 0.698089649 0.819475605 7915 aldehyde dehydrogenase 5 family member A1 "GO:0004777,GO:0005739,GO:0005759,GO:0006105,GO:0006536,GO:0007417,GO:0009450,GO:0009791,GO:0042135,GO:0042802,GO:0055114" succinate-semialdehyde dehydrogenase (NAD+) activity|mitochondrion|mitochondrial matrix|succinate metabolic process|glutamate metabolic process|central nervous system development|gamma-aminobutyric acid catabolic process|post-embryonic development|neurotransmitter catabolic process|identical protein binding|oxidation-reduction process "hsa00250,hsa00650" "Alanine, aspartate and glutamate metabolism|Butanoate metabolism" ALDH6A1 526.6953007 542.0556329 511.3349686 0.943325625 -0.084172237 0.760926649 1 5.237825977 4.85829493 4329 aldehyde dehydrogenase 6 family member A1 "GO:0000062,GO:0003723,GO:0004491,GO:0005654,GO:0005739,GO:0005759,GO:0006210,GO:0006573,GO:0006574,GO:0009083,GO:0018478,GO:0019859,GO:0050873,GO:0055114" fatty-acyl-CoA binding|RNA binding|methylmalonate-semialdehyde dehydrogenase (acylating) activity|nucleoplasm|mitochondrion|mitochondrial matrix|thymine catabolic process|valine metabolic process|valine catabolic process|branched-chain amino acid catabolic process|malonate-semialdehyde dehydrogenase (acetylating) activity|thymine metabolic process|brown fat cell differentiation|oxidation-reduction process "hsa00280,hsa00410,hsa00562,hsa00640" "Valine, leucine and isoleucine degradation|beta-Alanine metabolism|Inositol phosphate metabolism|Propanoate metabolism" ALDH7A1 1216.801591 1147.576513 1286.026669 1.120645687 0.164330215 0.498065587 1 12.85289597 14.16251866 501 aldehyde dehydrogenase 7 family member A1 "GO:0004029,GO:0004043,GO:0005515,GO:0005634,GO:0005739,GO:0005759,GO:0005829,GO:0006081,GO:0006554,GO:0007605,GO:0008802,GO:0019285,GO:0042426,GO:0043878,GO:0055114,GO:0070062" aldehyde dehydrogenase (NAD+) activity|L-aminoadipate-semialdehyde dehydrogenase activity|protein binding|nucleus|mitochondrion|mitochondrial matrix|cytosol|cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound|betaine-aldehyde dehydrogenase activity|glycine betaine biosynthetic process from choline|choline catabolic process|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity|oxidation-reduction process|extracellular exosome "hsa00010,hsa00053,hsa00071,hsa00260,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa00561,hsa00620" "Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Fatty acid degradation|Glycine, serine and threonine metabolism|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Glycerolipid metabolism|Pyruvate metabolism" ALDH9A1 1747.574259 1708.359595 1786.788922 1.045909144 0.064757533 0.78685199 1 36.13635029 37.16288538 223 aldehyde dehydrogenase 9 family member A1 "GO:0004029,GO:0005737,GO:0005829,GO:0006081,GO:0019145,GO:0033737,GO:0042136,GO:0042445,GO:0043878,GO:0045329,GO:0047105,GO:0051289,GO:0055114,GO:0070062" aldehyde dehydrogenase (NAD+) activity|cytoplasm|cytosol|cellular aldehyde metabolic process|aminobutyraldehyde dehydrogenase activity|1-pyrroline dehydrogenase activity|neurotransmitter biosynthetic process|hormone metabolic process|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity|carnitine biosynthetic process|4-trimethylammoniobutyraldehyde dehydrogenase activity|protein homotetramerization|oxidation-reduction process|extracellular exosome "hsa00010,hsa00053,hsa00071,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa00561,hsa00620" "Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Glycerolipid metabolism|Pyruvate metabolism" ALDOA 40.91832522 27.05076095 54.78588949 2.025299384 1.018135186 0.116782214 1 0.6727164 1.33965332 226 "aldolase, fructose-bisphosphate A" "GO:0002576,GO:0003723,GO:0003779,GO:0004332,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005829,GO:0006000,GO:0006094,GO:0006096,GO:0006754,GO:0006941,GO:0007015,GO:0007339,GO:0008092,GO:0008360,GO:0015629,GO:0015631,GO:0016020,GO:0030388,GO:0031093,GO:0031430,GO:0031674,GO:0034774,GO:0042802,GO:0043312,GO:0045296,GO:0046716,GO:0051289,GO:0061621,GO:0061827,GO:0070061,GO:0070062,GO:1904724,GO:1904813" "platelet degranulation|RNA binding|actin binding|fructose-bisphosphate aldolase activity|protein binding|extracellular region|extracellular space|nucleus|cytosol|fructose metabolic process|gluconeogenesis|glycolytic process|ATP biosynthetic process|striated muscle contraction|actin filament organization|binding of sperm to zona pellucida|cytoskeletal protein binding|regulation of cell shape|actin cytoskeleton|tubulin binding|membrane|fructose 1,6-bisphosphate metabolic process|platelet alpha granule lumen|M band|I band|secretory granule lumen|identical protein binding|neutrophil degranulation|cadherin binding|muscle cell cellular homeostasis|protein homotetramerization|canonical glycolysis|sperm head|fructose binding|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen" "hsa00010,hsa00030,hsa00051,hsa04066" Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|HIF-1 signaling pathway ALDOC 287.5724861 232.0122958 343.1326763 1.478941774 0.564565254 0.077829782 1 7.432214771 10.80787979 230 "aldolase, fructose-bisphosphate C" "GO:0004332,GO:0005515,GO:0005576,GO:0005829,GO:0005856,GO:0006000,GO:0006094,GO:0006096,GO:0008092,GO:0030388,GO:0030855,GO:0034774,GO:0043312,GO:0061621,GO:0070062,GO:1904724,GO:1904813" "fructose-bisphosphate aldolase activity|protein binding|extracellular region|cytosol|cytoskeleton|fructose metabolic process|gluconeogenesis|glycolytic process|cytoskeletal protein binding|fructose 1,6-bisphosphate metabolic process|epithelial cell differentiation|secretory granule lumen|neutrophil degranulation|canonical glycolysis|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen" "hsa00010,hsa00030,hsa00051,hsa04066" Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|HIF-1 signaling pathway ALG1 306.5226185 313.1645787 299.8806583 0.957581664 -0.062532568 0.851238776 1 4.046735591 3.810235588 56052 ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase "GO:0000030,GO:0004578,GO:0005783,GO:0005789,GO:0006486,GO:0006488,GO:0016020,GO:0016021,GO:0097502" mannosyltransferase activity|chitobiosyldiphosphodolichol beta-mannosyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|protein glycosylation|dolichol-linked oligosaccharide biosynthetic process|membrane|integral component of membrane|mannosylation "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis ALG10 533.5473097 532.6919079 534.4027115 1.003211619 0.004625963 0.994288757 1 2.789871254 2.751996608 84920 "ALG10 alpha-1,2-glucosyltransferase" "GO:0005515,GO:0005783,GO:0005789,GO:0006487,GO:0006488,GO:0016021,GO:0106073" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|integral component of membrane|dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity" hsa00510 N-Glycan biosynthesis ALG10B 547.2412669 538.9343912 555.5481426 1.030827039 0.043802285 0.87682273 1 2.836203327 2.874712003 144245 "ALG10 alpha-1,2-glucosyltransferase B" "GO:0005515,GO:0005783,GO:0005886,GO:0006486,GO:0006487,GO:0006488,GO:0016021,GO:0016740,GO:0060050,GO:0106073,GO:1901980" "protein binding|endoplasmic reticulum|plasma membrane|protein glycosylation|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|integral component of membrane|transferase activity|positive regulation of protein glycosylation|dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity|positive regulation of inward rectifier potassium channel activity" hsa00510 N-Glycan biosynthesis ALG11 119.1676329 138.3750464 99.96021942 0.722386167 -0.469157827 0.288364577 1 1.134381245 0.805748744 440138 "ALG11 alpha-1,2-mannosyltransferase" "GO:0004377,GO:0005789,GO:0006487,GO:0006490,GO:0016020,GO:0016021,GO:0097502" "GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity|endoplasmic reticulum membrane|protein N-linked glycosylation|oligosaccharide-lipid intermediate biosynthetic process|membrane|integral component of membrane|mannosylation" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis ALG12 483.2948277 512.9240441 453.6656112 0.88446938 -0.177115897 0.523420682 1 4.993399037 4.34260426 79087 "ALG12 alpha-1,6-mannosyltransferase" "GO:0000009,GO:0000030,GO:0005783,GO:0005788,GO:0005789,GO:0006457,GO:0006487,GO:0006488,GO:0016020,GO:0016021,GO:0052824,GO:0052917,GO:0097502" "alpha-1,6-mannosyltransferase activity|mannosyltransferase activity|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|protein folding|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|membrane|integral component of membrane|dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity|dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity|mannosylation" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis ALG13 795.6837615 778.2295842 813.1379388 1.044856113 0.063304283 0.805831516 1 3.460191834 3.554903726 79868 ALG13 UDP-N-acetylglucosaminyltransferase subunit "GO:0003723,GO:0004577,GO:0004843,GO:0005789,GO:0006488,GO:0006508,GO:0008234,GO:0018215" RNA binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity|thiol-dependent ubiquitin-specific protease activity|endoplasmic reticulum membrane|dolichol-linked oligosaccharide biosynthetic process|proteolysis|cysteine-type peptidase activity|protein phosphopantetheinylation "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis ALG14 88.79245508 85.31393838 92.27097178 1.081546269 0.113095386 0.837991141 1 0.407468059 0.433321116 199857 ALG14 UDP-N-acetylglucosaminyltransferase subunit "GO:0005789,GO:0006488,GO:0016021,GO:0031965,GO:0043541" endoplasmic reticulum membrane|dolichol-linked oligosaccharide biosynthetic process|integral component of membrane|nuclear membrane|UDP-N-acetylglucosamine transferase complex "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis ALG2 920.3805564 910.3621473 930.3989654 1.022009722 0.031408921 0.903581425 1 17.30212059 17.38703549 85365 "ALG2 alpha-1,3/1,6-mannosyltransferase" "GO:0000033,GO:0004378,GO:0005515,GO:0005634,GO:0005737,GO:0005789,GO:0005829,GO:0006488,GO:0006490,GO:0015629,GO:0016020,GO:0016021,GO:0033577,GO:0046982,GO:0047485,GO:0048306,GO:0048471,GO:0051592,GO:0097502,GO:0102704" "alpha-1,3-mannosyltransferase activity|GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum membrane|cytosol|dolichol-linked oligosaccharide biosynthetic process|oligosaccharide-lipid intermediate biosynthetic process|actin cytoskeleton|membrane|integral component of membrane|protein glycosylation in endoplasmic reticulum|protein heterodimerization activity|protein N-terminus binding|calcium-dependent protein binding|perinuclear region of cytoplasm|response to calcium ion|mannosylation|GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis ALG3 634.6014345 700.198543 569.0043259 0.812632833 -0.299324439 0.250459355 1 16.70465325 13.34759465 10195 "ALG3 alpha-1,3- mannosyltransferase" "GO:0000033,GO:0005515,GO:0005783,GO:0005789,GO:0006486,GO:0006488,GO:0016021,GO:0052925,GO:0097502" "alpha-1,3-mannosyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein glycosylation|dolichol-linked oligosaccharide biosynthetic process|integral component of membrane|dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity|mannosylation" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis ALG5 389.3210393 266.345954 512.2961245 1.923423716 0.943676613 0.001280122 0.222914621 11.54703009 21.83818007 29880 ALG5 dolichyl-phosphate beta-glucosyltransferase "GO:0004576,GO:0004581,GO:0005789,GO:0006486,GO:0006487,GO:0007368,GO:0016020,GO:0016021,GO:0018279" oligosaccharyl transferase activity|dolichyl-phosphate beta-glucosyltransferase activity|endoplasmic reticulum membrane|protein glycosylation|protein N-linked glycosylation|determination of left/right symmetry|membrane|integral component of membrane|protein N-linked glycosylation via asparagine hsa00510 N-Glycan biosynthesis ALG6 385.0593897 406.8018281 363.3169514 0.893105503 -0.163097483 0.581340182 1 6.529403277 5.733864647 29929 "ALG6 alpha-1,3-glucosyltransferase" "GO:0004583,GO:0005789,GO:0006487,GO:0006488,GO:0006490,GO:0016020,GO:0016021,GO:0042281,GO:0046527" "dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity|endoplasmic reticulum membrane|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|oligosaccharide-lipid intermediate biosynthetic process|membrane|integral component of membrane|dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity|glucosyltransferase activity" hsa00510 N-Glycan biosynthesis ALG8 627.5965544 591.9954992 663.1976096 1.12027475 0.163852599 0.532553768 1 12.57711455 13.85404973 79053 "ALG8 alpha-1,3-glucosyltransferase" "GO:0000033,GO:0004583,GO:0005515,GO:0005789,GO:0006487,GO:0006488,GO:0006490,GO:0016021,GO:0018279,GO:0042283,GO:0097502" "alpha-1,3-mannosyltransferase activity|dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity|protein binding|endoplasmic reticulum membrane|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|oligosaccharide-lipid intermediate biosynthetic process|integral component of membrane|protein N-linked glycosylation via asparagine|dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity|mannosylation" hsa00510 N-Glycan biosynthesis ALG9 852.902109 804.2399313 901.5642867 1.12101408 0.164804399 0.511221598 1 6.309099956 6.95423967 79796 "ALG9 alpha-1,2-mannosyltransferase" "GO:0000026,GO:0000030,GO:0005789,GO:0006487,GO:0006488,GO:0016020,GO:0016021,GO:0052918,GO:0052926,GO:0097502" "alpha-1,2-mannosyltransferase activity|mannosyltransferase activity|endoplasmic reticulum membrane|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|membrane|integral component of membrane|dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity|dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity|mannosylation" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis ALK 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.018192896 238 ALK receptor tyrosine kinase "GO:0000187,GO:0004704,GO:0004713,GO:0004714,GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0007165,GO:0007169,GO:0007275,GO:0016310,GO:0018108,GO:0021766,GO:0030534,GO:0032991,GO:0033674,GO:0036269,GO:0038061,GO:0042127,GO:0042802,GO:0042981,GO:0043235,GO:0045664,GO:0046777,GO:0048666,GO:0050995,GO:0051092,GO:0060159,GO:0070062,GO:0090648,GO:0097009,GO:1900006" activation of MAPK activity|NF-kappaB-inducing kinase activity|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|protein binding|ATP binding|plasma membrane|integral component of plasma membrane|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|phosphorylation|peptidyl-tyrosine phosphorylation|hippocampus development|adult behavior|protein-containing complex|positive regulation of kinase activity|swimming behavior|NIK/NF-kappaB signaling|regulation of cell population proliferation|identical protein binding|regulation of apoptotic process|receptor complex|regulation of neuron differentiation|protein autophosphorylation|neuron development|negative regulation of lipid catabolic process|positive regulation of NF-kappaB transcription factor activity|regulation of dopamine receptor signaling pathway|extracellular exosome|response to environmental enrichment|energy homeostasis|positive regulation of dendrite development "hsa05200,hsa05223,hsa05235" Pathways in cancer|Non-small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer ALKBH1 363.2157286 350.6194785 375.8119788 1.0718514 0.100104906 0.743452084 1 7.205204911 7.593676547 8846 "alkB homolog 1, histone H2A dioxygenase" "GO:0000049,GO:0000791,GO:0001701,GO:0001764,GO:0001890,GO:0002101,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0006281,GO:0006307,GO:0006446,GO:0006448,GO:0008198,GO:0016706,GO:0031175,GO:0035511,GO:0035513,GO:0035515,GO:0035516,GO:0035552,GO:0042056,GO:0042245,GO:0043524,GO:0048589,GO:0050918,GO:0070129,GO:0070579,GO:0070989,GO:0080111,GO:0103053,GO:0140078,GO:1990983,GO:1990984" tRNA binding|euchromatin|in utero embryonic development|neuron migration|placenta development|tRNA wobble cytosine modification|nucleus|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|DNA repair|DNA dealkylation involved in DNA repair|regulation of translational initiation|regulation of translational elongation|ferrous iron binding|2-oxoglutarate-dependent dioxygenase activity|neuron projection development|oxidative DNA demethylation|oxidative RNA demethylation|oxidative RNA demethylase activity|oxidative DNA demethylase activity|oxidative single-stranded DNA demethylation|chemoattractant activity|RNA repair|negative regulation of neuron apoptotic process|developmental growth|positive chemotaxis|regulation of mitochondrial translation|methylcytosine dioxygenase activity|oxidative demethylation|DNA demethylation|1-ethyladenine demethylase activity|class I DNA-(apurinic or apyrimidinic site) endonuclease activity|tRNA demethylation|tRNA demethylase activity ALKBH2 243.3096223 255.9418151 230.6774294 0.901288558 -0.14993902 0.665353712 1 11.57554599 10.25832658 121642 "alkB homolog 2, alpha-ketoglutarate dependent dioxygenase" "GO:0005515,GO:0005654,GO:0006307,GO:0008198,GO:0035511,GO:0043734,GO:0051747,GO:0070989,GO:0080111,GO:0103053" protein binding|nucleoplasm|DNA dealkylation involved in DNA repair|ferrous iron binding|oxidative DNA demethylation|DNA-N1-methyladenine dioxygenase activity|cytosine C-5 DNA demethylase activity|oxidative demethylation|DNA demethylation|1-ethyladenine demethylase activity ALKBH3 529.2667673 521.2473552 537.2861794 1.030770083 0.04372257 0.878174506 1 18.01684802 18.26046357 221120 "alkB homolog 3, alpha-ketoglutarate dependent dioxygenase" "GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006281,GO:0006307,GO:0008198,GO:0008283,GO:0031418,GO:0035552,GO:0035553,GO:0043734,GO:1990930" protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|DNA repair|DNA dealkylation involved in DNA repair|ferrous iron binding|cell population proliferation|L-ascorbic acid binding|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|DNA-N1-methyladenine dioxygenase activity|RNA N1-methyladenosine dioxygenase activity ALKBH4 208.401037 222.6485709 194.1535031 0.872017738 -0.197570614 0.58786386 1 5.631443136 4.828544084 54784 "alkB homolog 4, lysine demethylase" "GO:0003779,GO:0005515,GO:0005730,GO:0005737,GO:0006325,GO:0006482,GO:0016491,GO:0016706,GO:0030496,GO:0031032,GO:0032451,GO:0035511,GO:0035516,GO:0036090,GO:0046872,GO:0070938,GO:0070989,GO:0080111,GO:1902275" actin binding|protein binding|nucleolus|cytoplasm|chromatin organization|protein demethylation|oxidoreductase activity|2-oxoglutarate-dependent dioxygenase activity|midbody|actomyosin structure organization|demethylase activity|oxidative DNA demethylation|oxidative DNA demethylase activity|cleavage furrow ingression|metal ion binding|contractile ring|oxidative demethylation|DNA demethylation|regulation of chromatin organization ALKBH5 1608.876536 1536.691305 1681.061767 1.093948903 0.129545353 0.587343041 1 25.96087072 27.92463275 54890 "alkB homolog 5, RNA demethylase" "GO:0001666,GO:0003723,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006307,GO:0006397,GO:0006406,GO:0007283,GO:0016607,GO:0016706,GO:0030154,GO:0035515,GO:0035553,GO:0043488,GO:0046872,GO:1990931" response to hypoxia|RNA binding|nucleus|nucleoplasm|Golgi apparatus|cytosol|DNA dealkylation involved in DNA repair|mRNA processing|mRNA export from nucleus|spermatogenesis|nuclear speck|2-oxoglutarate-dependent dioxygenase activity|cell differentiation|oxidative RNA demethylase activity|oxidative single-stranded RNA demethylation|regulation of mRNA stability|metal ion binding|RNA N6-methyladenosine dioxygenase activity ALKBH6 204.6853609 200.7998793 208.5708425 1.038700039 0.054779085 0.892832533 1 6.697700316 6.840487252 84964 alkB homolog 6 "GO:0005515,GO:0005654,GO:0005737,GO:0005925,GO:0046872,GO:0051213,GO:0055114" protein binding|nucleoplasm|cytoplasm|focal adhesion|metal ion binding|dioxygenase activity|oxidation-reduction process ALKBH7 259.3372722 235.1335375 283.541007 1.205872246 0.270077072 0.417739427 1 13.65467327 16.19025881 84266 alkB homolog 7 "GO:0005515,GO:0005739,GO:0005759,GO:0006631,GO:0006974,GO:0010883,GO:0046872,GO:0051213,GO:0055114,GO:1902445" protein binding|mitochondrion|mitochondrial matrix|fatty acid metabolic process|cellular response to DNA damage stimulus|regulation of lipid storage|metal ion binding|dioxygenase activity|oxidation-reduction process|regulation of mitochondrial membrane permeability involved in programmed necrotic cell death ALKBH8 336.8185384 364.1448589 309.4922178 0.84991511 -0.234609344 0.442817291 1 4.119063555 3.442272298 91801 "alkB homolog 8, tRNA methyltransferase" "GO:0000049,GO:0002098,GO:0005506,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006974,GO:0008270,GO:0016300,GO:0016604,GO:0016706,GO:0030488,GO:0055114,GO:0106335" tRNA binding|tRNA wobble uridine modification|iron ion binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cellular response to DNA damage stimulus|zinc ion binding|tRNA (uracil) methyltransferase activity|nuclear body|2-oxoglutarate-dependent dioxygenase activity|tRNA methylation|oxidation-reduction process|tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity ALMS1 905.1153032 1026.888502 783.3421041 0.762830728 -0.390565135 0.115442832 1 4.24107352 3.181084157 7840 ALMS1 centrosome and basal body associated protein "GO:0000086,GO:0000922,GO:0003674,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0005929,GO:0008017,GO:0010389,GO:0016197,GO:0046599,GO:0051492,GO:0097711,GO:0120162" G2/M transition of mitotic cell cycle|spindle pole|molecular_function|protein binding|centrosome|centriole|cytosol|cilium|microtubule binding|regulation of G2/M transition of mitotic cell cycle|endosomal transport|regulation of centriole replication|regulation of stress fiber assembly|ciliary basal body-plasma membrane docking|positive regulation of cold-induced thermogenesis ALOX5AP 93.01324686 145.6579436 40.36855015 0.277146232 -1.851280704 0.00018329 0.056965773 5.788158407 1.57732274 241 arachidonate 5-lipoxygenase activating protein "GO:0004364,GO:0004464,GO:0004602,GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0006691,GO:0008047,GO:0016020,GO:0016021,GO:0019370,GO:0019372,GO:0031965,GO:0047485,GO:0050544,GO:0050790,GO:0070207,GO:0071277,GO:0098869,GO:2001301" glutathione transferase activity|leukotriene-C4 synthase activity|glutathione peroxidase activity|protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|leukotriene metabolic process|enzyme activator activity|membrane|integral component of membrane|leukotriene biosynthetic process|lipoxygenase pathway|nuclear membrane|protein N-terminus binding|arachidonic acid binding|regulation of catalytic activity|protein homotrimerization|cellular response to calcium ion|cellular oxidant detoxification|lipoxin biosynthetic process hsa04664 Fc epsilon RI signaling pathway ALOXE3 49.62786508 79.07145508 20.18427508 0.255266266 -1.969925201 0.001535668 0.247303919 1.17709853 0.295445528 59344 arachidonate lipoxygenase 3 "GO:0005506,GO:0005515,GO:0005829,GO:0006665,GO:0016702,GO:0019233,GO:0019369,GO:0019372,GO:0035357,GO:0043651,GO:0045444,GO:0046513,GO:0050486,GO:0051120,GO:0051122,GO:0055114,GO:0061436,GO:0106255,GO:0106256" "iron ion binding|protein binding|cytosol|sphingolipid metabolic process|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sensory perception of pain|arachidonic acid metabolic process|lipoxygenase pathway|peroxisome proliferator activated receptor signaling pathway|linoleic acid metabolic process|fat cell differentiation|ceramide biosynthetic process|intramolecular transferase activity, transferring hydroxy groups|hepoxilin A3 synthase activity|hepoxilin biosynthetic process|oxidation-reduction process|establishment of skin barrier|hydroperoxy icosatetraenoate isomerase activity|hydroperoxy icosatetraenoate dehydratase activity" ALPK1 579.6375218 645.0566072 514.2184365 0.797167924 -0.327044434 0.216816913 1 6.37627071 4.997902058 80216 alpha kinase 1 "GO:0002753,GO:0004674,GO:0005515,GO:0005524,GO:0005829,GO:0006468,GO:0043123,GO:0045087,GO:0048029,GO:0106310,GO:0106311" cytoplasmic pattern recognition receptor signaling pathway|protein serine/threonine kinase activity|protein binding|ATP binding|cytosol|protein phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|monosaccharide binding|protein serine kinase activity|protein threonine kinase activity ALPK2 70.892183 82.19269673 59.59166927 0.725023897 -0.463899548 0.385703522 1 0.589817556 0.420475983 115701 alpha kinase 2 "GO:0003007,GO:0003308,GO:0005524,GO:0006468,GO:0010468,GO:0016323,GO:0030010,GO:0042981,GO:0055013,GO:0106310,GO:0106311,GO:1905223" heart morphogenesis|negative regulation of Wnt signaling pathway involved in heart development|ATP binding|protein phosphorylation|regulation of gene expression|basolateral plasma membrane|establishment of cell polarity|regulation of apoptotic process|cardiac muscle cell development|protein serine kinase activity|protein threonine kinase activity|epicardium morphogenesis ALPK3 5.643018428 9.363724944 1.922311912 0.205293505 -2.284240111 0.166157707 1 0.048810782 0.009852856 57538 alpha kinase 3 "GO:0005524,GO:0005634,GO:0006468,GO:0007507,GO:0055013,GO:0106310,GO:0106311" ATP binding|nucleus|protein phosphorylation|heart development|cardiac muscle cell development|protein serine kinase activity|protein threonine kinase activity ALPP 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.080646299 0.036628012 250 "alkaline phosphatase, placental" "GO:0000287,GO:0004035,GO:0005515,GO:0005886,GO:0008270,GO:0009986,GO:0016021,GO:0016311,GO:0031225" magnesium ion binding|alkaline phosphatase activity|protein binding|plasma membrane|zinc ion binding|cell surface|integral component of membrane|dephosphorylation|anchored component of membrane "hsa00730,hsa00790" Thiamine metabolism|Folate biosynthesis ALS2 1500.934575 1566.863307 1435.005842 0.915846223 -0.126822714 0.596432043 1 7.616414513 6.858739515 57679 alsin Rho guanine nucleotide exchange factor ALS2 "GO:0001726,GO:0005085,GO:0005096,GO:0005515,GO:0005634,GO:0005769,GO:0005813,GO:0005829,GO:0007032,GO:0007041,GO:0030027,GO:0030425,GO:0030426,GO:0031267,GO:0031982,GO:0032991,GO:0035022,GO:0042802,GO:0042803,GO:0043539,GO:0043547,GO:0045860,GO:0048812,GO:0051036,GO:0051260,GO:0071902" ruffle|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|nucleus|early endosome|centrosome|cytosol|endosome organization|lysosomal transport|lamellipodium|dendrite|growth cone|small GTPase binding|vesicle|protein-containing complex|positive regulation of Rac protein signal transduction|identical protein binding|protein homodimerization activity|protein serine/threonine kinase activator activity|positive regulation of GTPase activity|positive regulation of protein kinase activity|neuron projection morphogenesis|regulation of endosome size|protein homooligomerization|positive regulation of protein serine/threonine kinase activity "hsa05014,hsa05022" Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases ALS2CL 761.370225 659.6224016 863.1180485 1.308503238 0.387917495 0.125565628 1 4.72711632 6.081941934 259173 ALS2 C-terminal like "GO:0005096,GO:0005515,GO:0005829,GO:0007032,GO:0042802,GO:0043547" GTPase activator activity|protein binding|cytosol|endosome organization|identical protein binding|positive regulation of GTPase activity ALYREF 1053.198716 864.5839365 1241.813495 1.436313402 0.522370578 0.032916488 0.920517339 42.06130871 59.40228796 10189 Aly/REF export factor "GO:0000018,GO:0000346,GO:0000398,GO:0000781,GO:0001649,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006405,GO:0006406,GO:0016020,GO:0016032,GO:0016607,GO:0031124,GO:0031297,GO:0032786,GO:0035145,GO:0046784,GO:0062153,GO:0070062,GO:0071013" "regulation of DNA recombination|transcription export complex|mRNA splicing, via spliceosome|chromosome, telomeric region|osteoblast differentiation|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|membrane|viral process|nuclear speck|mRNA 3'-end processing|replication fork processing|positive regulation of DNA-templated transcription, elongation|exon-exon junction complex|viral mRNA export from host cell nucleus|C5-methylcytidine-containing RNA binding|extracellular exosome|catalytic step 2 spliceosome" "hsa03013,hsa03015,hsa03040,hsa05014,hsa05168" RNA transport|mRNA surveillance pathway|Spliceosome|Amyotrophic lateral sclerosis|Herpes simplex virus 1 infection AMACR 258.1679106 254.9014012 261.43442 1.025629591 0.036509792 0.924592403 1 3.311494473 3.339533126 23600 alpha-methylacyl-CoA racemase "GO:0005737,GO:0005739,GO:0005777,GO:0005782,GO:0005829,GO:0005886,GO:0006625,GO:0006699,GO:0008111,GO:0008206,GO:0008410,GO:0033540,GO:0043231" cytoplasm|mitochondrion|peroxisome|peroxisomal matrix|cytosol|plasma membrane|protein targeting to peroxisome|bile acid biosynthetic process|alpha-methylacyl-CoA racemase activity|bile acid metabolic process|CoA-transferase activity|fatty acid beta-oxidation using acyl-CoA oxidase|intracellular membrane-bounded organelle "hsa00120,hsa04146" Primary bile acid biosynthesis|Peroxisome AMBRA1 1048.782966 1089.313335 1008.252598 0.925585472 -0.111561874 0.650880818 1 9.205803741 8.378174855 55626 autophagy and beclin 1 regulator 1 "GO:0000045,GO:0000422,GO:0000423,GO:0005515,GO:0005737,GO:0005739,GO:0005741,GO:0005776,GO:0005829,GO:0005930,GO:0006914,GO:0008285,GO:0009267,GO:0010508,GO:0010667,GO:0016236,GO:0021915,GO:0030154,GO:0031625,GO:0043231,GO:0043524,GO:0043552,GO:0045335,GO:0048471,GO:0051020,GO:0098780" autophagosome assembly|autophagy of mitochondrion|mitophagy|protein binding|cytoplasm|mitochondrion|mitochondrial outer membrane|autophagosome|cytosol|axoneme|autophagy|negative regulation of cell population proliferation|cellular response to starvation|positive regulation of autophagy|negative regulation of cardiac muscle cell apoptotic process|macroautophagy|neural tube development|cell differentiation|ubiquitin protein ligase binding|intracellular membrane-bounded organelle|negative regulation of neuron apoptotic process|positive regulation of phosphatidylinositol 3-kinase activity|phagocytic vesicle|perinuclear region of cytoplasm|GTPase binding|response to mitochondrial depolarisation "hsa04137,hsa04140,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022" Mitophagy - animal|Autophagy - animal|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases AMD1 1476.713176 1448.256125 1505.170227 1.039298368 0.055609892 0.818336882 1 20.92332636 21.38169613 262 adenosylmethionine decarboxylase 1 "GO:0004014,GO:0005515,GO:0005829,GO:0006557,GO:0006595,GO:0006597,GO:0008295,GO:0019810,GO:0042802" adenosylmethionine decarboxylase activity|protein binding|cytosol|S-adenosylmethioninamine biosynthetic process|polyamine metabolic process|spermine biosynthetic process|spermidine biosynthetic process|putrescine binding|identical protein binding "hsa00270,hsa00330" Cysteine and methionine metabolism|Arginine and proline metabolism AMDHD1 40.15028366 44.73779695 35.56277037 0.794915548 -0.331126499 0.632535688 1 1.072584905 0.83834707 144193 amidohydrolase domain containing 1 "GO:0003674,GO:0005829,GO:0006548,GO:0016812,GO:0019556,GO:0019557,GO:0046872,GO:0050480" "molecular_function|cytosol|histidine catabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides|histidine catabolic process to glutamate and formamide|histidine catabolic process to glutamate and formate|metal ion binding|imidazolonepropionase activity" hsa00340 Histidine metabolism AMDHD2 515.9835766 588.8742576 443.0928957 0.752440593 -0.410350412 0.13027106 1 9.593143108 7.097482313 51005 amidohydrolase domain containing 2 "GO:0005515,GO:0005634,GO:0005829,GO:0005975,GO:0006046,GO:0006048,GO:0008448,GO:0019262,GO:0046872,GO:0047419" protein binding|nucleus|cytosol|carbohydrate metabolic process|N-acetylglucosamine catabolic process|UDP-N-acetylglucosamine biosynthetic process|N-acetylglucosamine-6-phosphate deacetylase activity|N-acetylneuraminate catabolic process|metal ion binding|N-acetylgalactosamine-6-phosphate deacetylase activity hsa00520 Amino sugar and nucleotide sugar metabolism AMER1 216.323028 241.3760208 191.2700352 0.792415231 -0.335671484 0.343635468 1 1.532270084 1.193876258 139285 APC membrane recruitment protein 1 "GO:0005515,GO:0005546,GO:0005829,GO:0005886,GO:0008013,GO:0016055,GO:0016604,GO:0031398,GO:0043231,GO:0060348,GO:0060612,GO:0060828,GO:0072161,GO:0090090,GO:0090263,GO:1903364,GO:1904713,GO:1904885,GO:1904886" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytosol|plasma membrane|beta-catenin binding|Wnt signaling pathway|nuclear body|positive regulation of protein ubiquitination|intracellular membrane-bounded organelle|bone development|adipose tissue development|regulation of canonical Wnt signaling pathway|mesenchymal cell differentiation involved in kidney development|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|positive regulation of cellular protein catabolic process|beta-catenin destruction complex binding|beta-catenin destruction complex assembly|beta-catenin destruction complex disassembly" AMFR 2086.325784 1946.614374 2226.037194 1.143542976 0.193510585 0.413632697 1 24.11495623 27.11503361 267 autocrine motility factor receptor "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006457,GO:0006511,GO:0007165,GO:0007568,GO:0007611,GO:0016020,GO:0016021,GO:0016055,GO:0016567,GO:0030176,GO:0030425,GO:0030426,GO:0030433,GO:0030674,GO:0030968,GO:0032092,GO:0032991,GO:0034450,GO:0036513,GO:0038023,GO:0042802,GO:0043025,GO:0043130,GO:0044322,GO:0046872,GO:0048471,GO:0051087,GO:0051865,GO:0061630,GO:0070936,GO:0090090,GO:1904288,GO:1904380,GO:1990381,GO:2000638" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|protein folding|ubiquitin-dependent protein catabolic process|signal transduction|aging|learning or memory|membrane|integral component of membrane|Wnt signaling pathway|protein ubiquitination|integral component of endoplasmic reticulum membrane|dendrite|growth cone|ubiquitin-dependent ERAD pathway|protein-macromolecule adaptor activity|endoplasmic reticulum unfolded protein response|positive regulation of protein binding|protein-containing complex|ubiquitin-ubiquitin ligase activity|Derlin-1 retrotranslocation complex|signaling receptor activity|identical protein binding|neuronal cell body|ubiquitin binding|endoplasmic reticulum quality control compartment|metal ion binding|perinuclear region of cytoplasm|chaperone binding|protein autoubiquitination|ubiquitin protein ligase activity|protein K48-linked ubiquitination|negative regulation of canonical Wnt signaling pathway|BAT3 complex binding|endoplasmic reticulum mannose trimming|ubiquitin-specific protease binding|regulation of SREBP signaling pathway hsa04141 Protein processing in endoplasmic reticulum AMH 94.19266931 100.9201466 87.465192 0.866677219 -0.206433312 0.680415019 1 2.977292837 2.537173181 268 anti-Mullerian hormone "GO:0001546,GO:0001655,GO:0001880,GO:0005102,GO:0005160,GO:0005179,GO:0005576,GO:0005615,GO:0007267,GO:0007506,GO:0007530,GO:0007548,GO:0007568,GO:0008083,GO:0010628,GO:0014070,GO:0030509,GO:0042493,GO:0051092,GO:2000355" preantral ovarian follicle growth|urogenital system development|Mullerian duct regression|signaling receptor binding|transforming growth factor beta receptor binding|hormone activity|extracellular region|extracellular space|cell-cell signaling|gonadal mesoderm development|sex determination|sex differentiation|aging|growth factor activity|positive regulation of gene expression|response to organic cyclic compound|BMP signaling pathway|response to drug|positive regulation of NF-kappaB transcription factor activity|negative regulation of ovarian follicle development "hsa04024,hsa04060,hsa04350,hsa04390" cAMP signaling pathway|Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway AMHR2 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.085819129 0 269 anti-Mullerian hormone receptor type 2 "GO:0001880,GO:0004674,GO:0005026,GO:0005515,GO:0005524,GO:0005886,GO:0006468,GO:0007179,GO:0007548,GO:0008584,GO:0008585,GO:0017002,GO:0030509,GO:0032924,GO:0042562,GO:0043235,GO:0046872,GO:0048179,GO:0048185,GO:0071363,GO:1990262,GO:1990272" "Mullerian duct regression|protein serine/threonine kinase activity|transforming growth factor beta receptor activity, type II|protein binding|ATP binding|plasma membrane|protein phosphorylation|transforming growth factor beta receptor signaling pathway|sex differentiation|male gonad development|female gonad development|activin-activated receptor activity|BMP signaling pathway|activin receptor signaling pathway|hormone binding|receptor complex|metal ion binding|activin receptor complex|activin binding|cellular response to growth factor stimulus|anti-Mullerian hormone signaling pathway|anti-Mullerian hormone receptor activity" "hsa04060,hsa04350" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway AMIGO1 74.13734196 79.07145508 69.20322883 0.875198626 -0.192317622 0.730709874 1 0.822592248 0.707884524 57463 adhesion molecule with Ig like domain 1 "GO:0005515,GO:0007156,GO:0007157,GO:0007409,GO:0007413,GO:0007420,GO:0008076,GO:0010976,GO:0015459,GO:0016021,GO:0030425,GO:0032809,GO:0042552,GO:0043204,GO:0050772,GO:0051965,GO:1901381,GO:1903818,GO:1905232,GO:1990030" protein binding|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|axonogenesis|axonal fasciculation|brain development|voltage-gated potassium channel complex|positive regulation of neuron projection development|potassium channel regulator activity|integral component of membrane|dendrite|neuronal cell body membrane|myelination|perikaryon|positive regulation of axonogenesis|positive regulation of synapse assembly|positive regulation of potassium ion transmembrane transport|positive regulation of voltage-gated potassium channel activity|cellular response to L-glutamate|pericellular basket AMIGO2 2980.608019 3420.880846 2540.335192 0.742596806 -0.429348984 0.069868871 1 46.14917175 33.69676172 347902 adhesion molecule with Ig like domain 2 "GO:0005515,GO:0005634,GO:0005886,GO:0007156,GO:0007157,GO:0007420,GO:0016021,GO:0043066,GO:0043069,GO:0051965" protein binding|nucleus|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|brain development|integral component of membrane|negative regulation of apoptotic process|negative regulation of programmed cell death|positive regulation of synapse assembly AMIGO3 82.34679655 80.11186896 84.58172413 1.055795168 0.078329968 0.900396784 1 1.496996921 1.554074218 386724 adhesion molecule with Ig like domain 3 "GO:0007157,GO:0007420,GO:0016021,GO:0051965" heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|brain development|integral component of membrane|positive regulation of synapse assembly AMMECR1 463.4722437 509.8028025 417.1416849 0.818241255 -0.289401816 0.299228814 1 4.658773731 3.748212193 9949 AMMECR nuclear protein 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0008150" protein binding|nucleus|nucleoplasm|mitochondrion|biological_process AMMECR1L 899.2200341 947.8170471 850.6230211 0.897454866 -0.156088709 0.531491277 1 7.638667138 6.740643845 83607 AMMECR1 like GO:0005634 nucleus AMN1 513.298868 493.1561804 533.4415556 1.081688878 0.113285602 0.681575647 1 4.297654958 4.570935444 196394 antagonist of mitotic exit network 1 homolog "GO:0019005,GO:0031146" SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process AMOT 641.4534435 690.8348181 592.0720689 0.857038547 -0.222568001 0.392934379 1 4.645153653 3.914457827 154796 angiomotin "GO:0001525,GO:0001570,GO:0001701,GO:0001702,GO:0001726,GO:0003365,GO:0005515,GO:0005654,GO:0005829,GO:0005884,GO:0005886,GO:0005923,GO:0006935,GO:0008180,GO:0009897,GO:0016525,GO:0030027,GO:0030036,GO:0030054,GO:0030139,GO:0030334,GO:0031410,GO:0034260,GO:0034613,GO:0035329,GO:0038023,GO:0040019,GO:0042074,GO:0043532,GO:0043534,GO:0051056" angiogenesis|vasculogenesis|in utero embryonic development|gastrulation with mouth forming second|ruffle|establishment of cell polarity involved in ameboidal cell migration|protein binding|nucleoplasm|cytosol|actin filament|plasma membrane|bicellular tight junction|chemotaxis|COP9 signalosome|external side of plasma membrane|negative regulation of angiogenesis|lamellipodium|actin cytoskeleton organization|cell junction|endocytic vesicle|regulation of cell migration|cytoplasmic vesicle|negative regulation of GTPase activity|cellular protein localization|hippo signaling|signaling receptor activity|positive regulation of embryonic development|cell migration involved in gastrulation|angiostatin binding|blood vessel endothelial cell migration|regulation of small GTPase mediated signal transduction "hsa04390,hsa04530" Hippo signaling pathway|Tight junction AMOTL1 3660.136448 3244.010486 4076.262409 1.256550318 0.329468445 0.165653771 1 17.18722103 21.23521807 154810 angiomotin like 1 "GO:0001525,GO:0003365,GO:0005515,GO:0005829,GO:0005886,GO:0005923,GO:0008180,GO:0016055,GO:0030036,GO:0030334,GO:0031410,GO:0035329,GO:0042802" angiogenesis|establishment of cell polarity involved in ameboidal cell migration|protein binding|cytosol|plasma membrane|bicellular tight junction|COP9 signalosome|Wnt signaling pathway|actin cytoskeleton organization|regulation of cell migration|cytoplasmic vesicle|hippo signaling|identical protein binding hsa04530 Tight junction AMOTL2 3616.031601 4167.898014 3064.165188 0.735182382 -0.443825902 0.061888712 1 39.90546407 28.84686586 51421 angiomotin like 2 "GO:0001525,GO:0003365,GO:0005515,GO:0005829,GO:0005886,GO:0005923,GO:0016055,GO:0030036,GO:0030334,GO:0031410,GO:0035329,GO:0055037" angiogenesis|establishment of cell polarity involved in ameboidal cell migration|protein binding|cytosol|plasma membrane|bicellular tight junction|Wnt signaling pathway|actin cytoskeleton organization|regulation of cell migration|cytoplasmic vesicle|hippo signaling|recycling endosome hsa04530 Tight junction AMPD2 1724.521607 1670.904696 1778.138519 1.064177103 0.089738268 0.707015652 1 21.5289987 22.52728848 271 adenosine monophosphate deaminase 2 "GO:0003876,GO:0005515,GO:0005829,GO:0006188,GO:0032264,GO:0043101,GO:0046033,GO:0046872,GO:0052652,GO:0097009" AMP deaminase activity|protein binding|cytosol|IMP biosynthetic process|IMP salvage|purine-containing compound salvage|AMP metabolic process|metal ion binding|cyclic purine nucleotide metabolic process|energy homeostasis hsa00230 Purine metabolism AMPD3 1042.174376 991.5144302 1092.834322 1.102187007 0.140369025 0.568431699 1 9.963340767 10.7977048 272 adenosine monophosphate deaminase 3 "GO:0003876,GO:0005515,GO:0005576,GO:0005829,GO:0006188,GO:0006196,GO:0032264,GO:0034774,GO:0043101,GO:0043312,GO:0046033,GO:0046872,GO:1904813" AMP deaminase activity|protein binding|extracellular region|cytosol|IMP biosynthetic process|AMP catabolic process|IMP salvage|secretory granule lumen|purine-containing compound salvage|neutrophil degranulation|AMP metabolic process|metal ion binding|ficolin-1-rich granule lumen hsa00230 Purine metabolism AMT 117.4585571 106.122216 128.7948981 1.213646896 0.279348739 0.536544677 1 2.836027854 3.384340259 275 aminomethyltransferase "GO:0004047,GO:0005654,GO:0005739,GO:0005759,GO:0006546,GO:0008483,GO:0019464" aminomethyltransferase activity|nucleoplasm|mitochondrion|mitochondrial matrix|glycine catabolic process|transaminase activity|glycine decarboxylation via glycine cleavage system "hsa00260,hsa00630,hsa00670" "Glycine, serine and threonine metabolism|Glyoxylate and dicarboxylate metabolism|One carbon pool by folate" AMTN 5.682647391 10.40413883 0.961155956 0.092382077 -3.436243205 0.058049477 1 0.550297093 0.04998689 401138 amelotin "GO:0003674,GO:0005515,GO:0005604,GO:0005788,GO:0005911,GO:0007155,GO:0031012,GO:0031214,GO:0042475,GO:0043687,GO:0044267,GO:0070169,GO:0070175" molecular_function|protein binding|basement membrane|endoplasmic reticulum lumen|cell-cell junction|cell adhesion|extracellular matrix|biomineral tissue development|odontogenesis of dentin-containing tooth|post-translational protein modification|cellular protein metabolic process|positive regulation of biomineral tissue development|positive regulation of enamel mineralization AMY2B 75.85647863 86.35435226 65.35860501 0.756865211 -0.4018917 0.443373336 1 1.807992573 1.345508247 280 amylase alpha 2B "GO:0004556,GO:0005975,GO:0046872,GO:0070062,GO:0103025" alpha-amylase activity|carbohydrate metabolic process|metal ion binding|extracellular exosome|alpha-amylase activity (releasing maltohexaose) "hsa00500,hsa04970,hsa04972,hsa04973" Starch and sucrose metabolism|Salivary secretion|Pancreatic secretion|Carbohydrate digestion and absorption AMZ1 186.2749427 171.6682906 200.8815948 1.170172978 0.226721808 0.550787549 1 0.59452441 0.684054862 155185 archaelysin family metallopeptidase 1 "GO:0005575,GO:0006508,GO:0008237,GO:0046872" cellular_component|proteolysis|metallopeptidase activity|metal ion binding AMZ2 2255.14582 2202.55619 2307.73545 1.04775327 0.067299024 0.77731541 1 56.43128935 58.13667328 51321 archaelysin family metallopeptidase 2 "GO:0005575,GO:0006508,GO:0008237,GO:0046872" cellular_component|proteolysis|metallopeptidase activity|metal ion binding ANAPC1 1833.719791 2001.75631 1665.683272 0.832110913 -0.265152255 0.263272471 1 11.43668293 9.357341452 64682 anaphase promoting complex subunit 1 "GO:0005654,GO:0005680,GO:0005829,GO:0006511,GO:0007091,GO:0031145,GO:0051301,GO:0060090,GO:0070979,GO:1901990" nucleoplasm|anaphase-promoting complex|cytosol|ubiquitin-dependent protein catabolic process|metaphase/anaphase transition of mitotic cell cycle|anaphase-promoting complex-dependent catabolic process|cell division|molecular adaptor activity|protein K11-linked ubiquitination|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANAPC10 343.6560705 291.3158871 395.9962539 1.359336278 0.4429024 0.142600063 1 3.75349915 5.016888028 10393 anaphase promoting complex subunit 10 "GO:0005654,GO:0005680,GO:0005829,GO:0006511,GO:0007049,GO:0031145,GO:0051301,GO:0070979,GO:1901990" nucleoplasm|anaphase-promoting complex|cytosol|ubiquitin-dependent protein catabolic process|cell cycle|anaphase-promoting complex-dependent catabolic process|cell division|protein K11-linked ubiquitination|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANAPC11 771.1547773 727.249304 815.0602507 1.120743941 0.164456699 0.51744354 1 29.00744299 31.96590655 51529 anaphase promoting complex subunit 11 "GO:0000278,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005680,GO:0005730,GO:0005829,GO:0006511,GO:0008270,GO:0016567,GO:0031145,GO:0031461,GO:0034450,GO:0045842,GO:0051301,GO:0061630,GO:0070979,GO:0097602,GO:1901990" mitotic cell cycle|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|anaphase-promoting complex|nucleolus|cytosol|ubiquitin-dependent protein catabolic process|zinc ion binding|protein ubiquitination|anaphase-promoting complex-dependent catabolic process|cullin-RING ubiquitin ligase complex|ubiquitin-ubiquitin ligase activity|positive regulation of mitotic metaphase/anaphase transition|cell division|ubiquitin protein ligase activity|protein K11-linked ubiquitination|cullin family protein binding|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANAPC13 1776.924728 1620.964829 1932.884628 1.19242848 0.253902738 0.284558598 1 46.96412254 55.06425039 25847 anaphase promoting complex subunit 13 "GO:0005515,GO:0005680,GO:0007049,GO:0051301,GO:0070979" protein binding|anaphase-promoting complex|cell cycle|cell division|protein K11-linked ubiquitination "hsa04110,hsa04114,hsa04120,hsa04914" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation ANAPC15 394.3790697 336.0536841 452.7044553 1.347119454 0.429877785 0.138816026 1 4.769831776 6.31801058 25906 anaphase promoting complex subunit 15 "GO:0005515,GO:0005654,GO:0005680,GO:0005829,GO:0006511,GO:0007049,GO:0031145,GO:0051301,GO:0090266,GO:1901990" protein binding|nucleoplasm|anaphase-promoting complex|cytosol|ubiquitin-dependent protein catabolic process|cell cycle|anaphase-promoting complex-dependent catabolic process|cell division|regulation of mitotic cell cycle spindle assembly checkpoint|regulation of mitotic cell cycle phase transition ANAPC16 1041.078628 1126.768235 955.3890203 0.847901983 -0.238030596 0.33162395 1 17.22530787 14.36097156 119504 anaphase promoting complex subunit 16 "GO:0000776,GO:0000777,GO:0005515,GO:0005654,GO:0005680,GO:0005829,GO:0006511,GO:0007049,GO:0016567,GO:0031145,GO:0051301,GO:1901990" kinetochore|condensed chromosome kinetochore|protein binding|nucleoplasm|anaphase-promoting complex|cytosol|ubiquitin-dependent protein catabolic process|cell cycle|protein ubiquitination|anaphase-promoting complex-dependent catabolic process|cell division|regulation of mitotic cell cycle phase transition ANAPC2 486.5745852 523.328183 449.8209874 0.859539008 -0.21836498 0.42930251 1 10.5194212 8.890549704 29882 anaphase promoting complex subunit 2 "GO:0005515,GO:0005654,GO:0005680,GO:0005829,GO:0006511,GO:0007049,GO:0010629,GO:0031145,GO:0031625,GO:0031915,GO:0045773,GO:0050775,GO:0051301,GO:0070979,GO:0090129,GO:1901990" protein binding|nucleoplasm|anaphase-promoting complex|cytosol|ubiquitin-dependent protein catabolic process|cell cycle|negative regulation of gene expression|anaphase-promoting complex-dependent catabolic process|ubiquitin protein ligase binding|positive regulation of synaptic plasticity|positive regulation of axon extension|positive regulation of dendrite morphogenesis|cell division|protein K11-linked ubiquitination|positive regulation of synapse maturation|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANAPC4 529.9404597 538.9343912 520.9465281 0.966623279 -0.048974356 0.862613282 1 11.01146169 10.46582336 29945 anaphase promoting complex subunit 4 "GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005680,GO:0005829,GO:0006511,GO:0007049,GO:0019903,GO:0031145,GO:0034399,GO:0045842,GO:0051301,GO:0070979,GO:1901990" ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|anaphase-promoting complex|cytosol|ubiquitin-dependent protein catabolic process|cell cycle|protein phosphatase binding|anaphase-promoting complex-dependent catabolic process|nuclear periphery|positive regulation of mitotic metaphase/anaphase transition|cell division|protein K11-linked ubiquitination|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANAPC5 2383.974088 2417.921863 2350.026312 0.971919874 -0.041090713 0.863606563 1 50.01552166 47.79763892 51433 anaphase promoting complex subunit 5 "GO:0005634,GO:0005654,GO:0005680,GO:0005819,GO:0005829,GO:0006511,GO:0007049,GO:0019903,GO:0031145,GO:0045842,GO:0051301,GO:0070979,GO:1901990" nucleus|nucleoplasm|anaphase-promoting complex|spindle|cytosol|ubiquitin-dependent protein catabolic process|cell cycle|protein phosphatase binding|anaphase-promoting complex-dependent catabolic process|positive regulation of mitotic metaphase/anaphase transition|cell division|protein K11-linked ubiquitination|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04657,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|IL-17 signaling pathway|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANAPC7 1328.943608 1328.608528 1329.278687 1.000504407 0.000727522 1 1 14.13584435 13.90631104 51434 anaphase promoting complex subunit 7 "GO:0005634,GO:0005654,GO:0005680,GO:0005737,GO:0005819,GO:0005829,GO:0006511,GO:0007091,GO:0015630,GO:0016567,GO:0019903,GO:0031145,GO:0045842,GO:0051301,GO:0070979,GO:1901990" nucleus|nucleoplasm|anaphase-promoting complex|cytoplasm|spindle|cytosol|ubiquitin-dependent protein catabolic process|metaphase/anaphase transition of mitotic cell cycle|microtubule cytoskeleton|protein ubiquitination|protein phosphatase binding|anaphase-promoting complex-dependent catabolic process|positive regulation of mitotic metaphase/anaphase transition|cell division|protein K11-linked ubiquitination|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANG 92.59744994 84.27352449 100.9213754 1.197545445 0.260080405 0.600947069 1 3.134162449 3.690495539 283 angiogenin "GO:0001525,GO:0001541,GO:0001556,GO:0001666,GO:0001890,GO:0001938,GO:0003677,GO:0003779,GO:0004519,GO:0004540,GO:0005102,GO:0005507,GO:0005515,GO:0005576,GO:0005604,GO:0005615,GO:0005634,GO:0005694,GO:0005730,GO:0006651,GO:0007154,GO:0007202,GO:0008201,GO:0009303,GO:0009725,GO:0015629,GO:0016477,GO:0017148,GO:0019731,GO:0019843,GO:0030041,GO:0030426,GO:0031410,GO:0032148,GO:0032311,GO:0032431,GO:0034332,GO:0042277,GO:0042327,GO:0042592,GO:0042803,GO:0043025,GO:0045087,GO:0048662,GO:0050714,GO:0050830,GO:0061844,GO:0090501" angiogenesis|ovarian follicle development|oocyte maturation|response to hypoxia|placenta development|positive regulation of endothelial cell proliferation|DNA binding|actin binding|endonuclease activity|ribonuclease activity|signaling receptor binding|copper ion binding|protein binding|extracellular region|basement membrane|extracellular space|nucleus|chromosome|nucleolus|diacylglycerol biosynthetic process|cell communication|activation of phospholipase C activity|heparin binding|rRNA transcription|response to hormone|actin cytoskeleton|cell migration|negative regulation of translation|antibacterial humoral response|rRNA binding|actin filament polymerization|growth cone|cytoplasmic vesicle|activation of protein kinase B activity|angiogenin-PRI complex|activation of phospholipase A2 activity|adherens junction organization|peptide binding|positive regulation of phosphorylation|homeostatic process|protein homodimerization activity|neuronal cell body|innate immune response|negative regulation of smooth muscle cell proliferation|positive regulation of protein secretion|defense response to Gram-positive bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide|RNA phosphodiester bond hydrolysis hsa05014 Amyotrophic lateral sclerosis ANGEL1 577.0710857 653.3799183 500.7622531 0.766418188 -0.383796297 0.147340399 1 6.402806717 4.825111715 23357 angel homolog 1 "GO:0000175,GO:0005634,GO:0005783,GO:0005801,GO:0005829,GO:0008190,GO:0019904,GO:0048471,GO:0090503" "3'-5'-exoribonuclease activity|nucleus|endoplasmic reticulum|cis-Golgi network|cytosol|eukaryotic initiation factor 4E binding|protein domain specific binding|perinuclear region of cytoplasm|RNA phosphodiester bond hydrolysis, exonucleolytic" ANGEL2 504.1031053 554.5405994 453.6656112 0.818092691 -0.289663783 0.288963437 1 5.565026813 4.476524362 90806 angel homolog 2 "GO:0000175,GO:0003730,GO:0005737,GO:0015030,GO:0045930,GO:0070935,GO:0090503" "3'-5'-exoribonuclease activity|mRNA 3'-UTR binding|cytoplasm|Cajal body|negative regulation of mitotic cell cycle|3'-UTR-mediated mRNA stabilization|RNA phosphodiester bond hydrolysis, exonucleolytic" ANGPT1 54.77079824 37.45489978 72.0866967 1.924626608 0.944578579 0.104649259 1 0.457518691 0.865817791 284 angiopoietin 1 "GO:0000165,GO:0001525,GO:0001701,GO:0001933,GO:0001934,GO:0001936,GO:0002040,GO:0002092,GO:0002719,GO:0005102,GO:0005576,GO:0005615,GO:0005886,GO:0005902,GO:0007162,GO:0007171,GO:0010595,GO:0010628,GO:0014068,GO:0014842,GO:0030097,GO:0030154,GO:0030210,GO:0030971,GO:0031398,GO:0031589,GO:0032680,GO:0033138,GO:0034394,GO:0042308,GO:0043066,GO:0043116,GO:0043122,GO:0043393,GO:0043524,GO:0043536,GO:0045121,GO:0045785,GO:0048014,GO:0050731,GO:0050900,GO:0050918,GO:0051897,GO:0062023,GO:0070062,GO:0070374,GO:0072012,GO:1905605,GO:2000352,GO:2000446" MAPK cascade|angiogenesis|in utero embryonic development|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|regulation of endothelial cell proliferation|sprouting angiogenesis|positive regulation of receptor internalization|negative regulation of cytokine production involved in immune response|signaling receptor binding|extracellular region|extracellular space|plasma membrane|microvillus|negative regulation of cell adhesion|activation of transmembrane receptor protein tyrosine kinase activity|positive regulation of endothelial cell migration|positive regulation of gene expression|positive regulation of phosphatidylinositol 3-kinase signaling|regulation of skeletal muscle satellite cell proliferation|hemopoiesis|cell differentiation|heparin biosynthetic process|receptor tyrosine kinase binding|positive regulation of protein ubiquitination|cell-substrate adhesion|regulation of tumor necrosis factor production|positive regulation of peptidyl-serine phosphorylation|protein localization to cell surface|negative regulation of protein import into nucleus|negative regulation of apoptotic process|negative regulation of vascular permeability|regulation of I-kappaB kinase/NF-kappaB signaling|regulation of protein binding|negative regulation of neuron apoptotic process|positive regulation of blood vessel endothelial cell migration|membrane raft|positive regulation of cell adhesion|Tie signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|leukocyte migration|positive chemotaxis|positive regulation of protein kinase B signaling|collagen-containing extracellular matrix|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|glomerulus vasculature development|positive regulation of blood-brain barrier permeability|negative regulation of endothelial cell apoptotic process|regulation of macrophage migration inhibitory factor signaling pathway "hsa04010,hsa04014,hsa04015,hsa04066,hsa04151,hsa05323" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|HIF-1 signaling pathway|PI3K-Akt signaling pathway|Rheumatoid arthritis ANGPTL2 11.60809898 14.56579436 8.650403604 0.593884782 -0.751745031 0.514922909 1 0.092862224 0.05422661 23452 angiopoietin like 2 "GO:0001525,GO:0005102,GO:0005515,GO:0005615,GO:0007275,GO:0062023,GO:0070062" angiogenesis|signaling receptor binding|protein binding|extracellular space|multicellular organism development|collagen-containing extracellular matrix|extracellular exosome ANGPTL4 1078.913996 555.5810133 1602.246979 2.883912409 1.528027347 9.75E-10 1.90E-06 15.16641308 43.00670052 51129 angiopoietin like 4 "GO:0001525,GO:0001666,GO:0004857,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0006629,GO:0019216,GO:0042802,GO:0043066,GO:0043335,GO:0045766,GO:0051005,GO:0062023,GO:0070328,GO:0072562,GO:2000352" angiogenesis|response to hypoxia|enzyme inhibitor activity|signaling receptor binding|protein binding|extracellular region|extracellular space|lipid metabolic process|regulation of lipid metabolic process|identical protein binding|negative regulation of apoptotic process|protein unfolding|positive regulation of angiogenesis|negative regulation of lipoprotein lipase activity|collagen-containing extracellular matrix|triglyceride homeostasis|blood microparticle|negative regulation of endothelial cell apoptotic process "hsa03320,hsa04979" PPAR signaling pathway|Cholesterol metabolism ANK2 319.1164111 366.2256867 272.0071355 0.742730905 -0.429088486 0.164474082 1 1.139438687 0.832134704 287 ankyrin 2 "GO:0002027,GO:0003283,GO:0005515,GO:0005739,GO:0005764,GO:0005769,GO:0005829,GO:0005856,GO:0005886,GO:0006874,GO:0006888,GO:0006897,GO:0008093,GO:0010628,GO:0010881,GO:0010882,GO:0014704,GO:0015031,GO:0016323,GO:0016324,GO:0019899,GO:0019901,GO:0030018,GO:0030315,GO:0030507,GO:0030674,GO:0031430,GO:0031647,GO:0031672,GO:0033292,GO:0033365,GO:0034394,GO:0034613,GO:0036309,GO:0036371,GO:0042383,GO:0043005,GO:0043034,GO:0043268,GO:0044325,GO:0045211,GO:0050821,GO:0051117,GO:0051279,GO:0051924,GO:0051928,GO:0055037,GO:0055117,GO:0060307,GO:0070296,GO:0070972,GO:0072659,GO:0086004,GO:0086005,GO:0086014,GO:0086015,GO:0086046,GO:0086066,GO:0086070,GO:0086091,GO:0098907,GO:0098910,GO:0140031,GO:1901018,GO:1901019,GO:1901021,GO:2001259" regulation of heart rate|atrial septum development|protein binding|mitochondrion|lysosome|early endosome|cytosol|cytoskeleton|plasma membrane|cellular calcium ion homeostasis|endoplasmic reticulum to Golgi vesicle-mediated transport|endocytosis|cytoskeletal anchor activity|positive regulation of gene expression|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of cardiac muscle contraction by calcium ion signaling|intercalated disc|protein transport|basolateral plasma membrane|apical plasma membrane|enzyme binding|protein kinase binding|Z disc|T-tubule|spectrin binding|protein-macromolecule adaptor activity|M band|regulation of protein stability|A band|T-tubule organization|protein localization to organelle|protein localization to cell surface|cellular protein localization|protein localization to M-band|protein localization to T-tubule|sarcolemma|neuron projection|costamere|positive regulation of potassium ion transport|ion channel binding|postsynaptic membrane|protein stabilization|ATPase binding|regulation of release of sequestered calcium ion into cytosol|regulation of calcium ion transport|positive regulation of calcium ion transport|recycling endosome|regulation of cardiac muscle contraction|regulation of ventricular cardiac muscle cell membrane repolarization|sarcoplasmic reticulum calcium ion transport|protein localization to endoplasmic reticulum|protein localization to plasma membrane|regulation of cardiac muscle cell contraction|ventricular cardiac muscle cell action potential|atrial cardiac muscle cell action potential|SA node cell action potential|membrane depolarization during SA node cell action potential|atrial cardiac muscle cell to AV node cell communication|SA node cell to atrial cardiac muscle cell communication|regulation of heart rate by cardiac conduction|regulation of SA node cell action potential|regulation of atrial cardiac muscle cell action potential|phosphorylation-dependent protein binding|positive regulation of potassium ion transmembrane transporter activity|regulation of calcium ion transmembrane transporter activity|positive regulation of calcium ion transmembrane transporter activity|positive regulation of cation channel activity hsa05205 Proteoglycans in cancer ANK3 301.3847157 342.2961674 260.4732641 0.760958751 -0.394109842 0.209928827 1 0.974278258 0.728979483 288 ankyrin 3 "GO:0000281,GO:0005200,GO:0005515,GO:0005764,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0005923,GO:0006888,GO:0007009,GO:0007010,GO:0007165,GO:0007409,GO:0007528,GO:0008092,GO:0008093,GO:0009925,GO:0009986,GO:0010628,GO:0010650,GO:0010765,GO:0010960,GO:0014704,GO:0014731,GO:0016323,GO:0016328,GO:0016529,GO:0019228,GO:0030018,GO:0030315,GO:0030425,GO:0030507,GO:0030674,GO:0031594,GO:0033268,GO:0034112,GO:0042383,GO:0043001,GO:0043005,GO:0043034,GO:0043194,GO:0043266,GO:0044325,GO:0045184,GO:0045211,GO:0045296,GO:0045838,GO:0071286,GO:0071709,GO:0072659,GO:0072660,GO:0090314,GO:0099612,GO:1900827,GO:1902260,GO:2000651,GO:2001259" mitotic cytokinesis|structural constituent of cytoskeleton|protein binding|lysosome|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|bicellular tight junction|endoplasmic reticulum to Golgi vesicle-mediated transport|plasma membrane organization|cytoskeleton organization|signal transduction|axonogenesis|neuromuscular junction development|cytoskeletal protein binding|cytoskeletal anchor activity|basal plasma membrane|cell surface|positive regulation of gene expression|positive regulation of cell communication by electrical coupling|positive regulation of sodium ion transport|magnesium ion homeostasis|intercalated disc|spectrin-associated cytoskeleton|basolateral plasma membrane|lateral plasma membrane|sarcoplasmic reticulum|neuronal action potential|Z disc|T-tubule|dendrite|spectrin binding|protein-macromolecule adaptor activity|neuromuscular junction|node of Ranvier|positive regulation of homotypic cell-cell adhesion|sarcolemma|Golgi to plasma membrane protein transport|neuron projection|costamere|axon initial segment|regulation of potassium ion transport|ion channel binding|establishment of protein localization|postsynaptic membrane|cadherin binding|positive regulation of membrane potential|cellular response to magnesium ion|membrane assembly|protein localization to plasma membrane|maintenance of protein location in plasma membrane|positive regulation of protein targeting to membrane|protein localization to axon|positive regulation of membrane depolarization during cardiac muscle cell action potential|negative regulation of delayed rectifier potassium channel activity|positive regulation of sodium ion transmembrane transporter activity|positive regulation of cation channel activity hsa05205 Proteoglycans in cancer ANKAR 69.01453047 70.74814402 67.28091692 0.950991971 -0.072494934 0.920021515 1 0.623670039 0.583180387 150709 ankyrin and armadillo repeat containing GO:0016021 integral component of membrane ANKDD1A 163.6135502 157.1024963 170.1246042 1.082889249 0.114885701 0.782909581 1 2.703731533 2.878848342 348094 ankyrin repeat and death domain containing 1A GO:0007165 signal transduction ANKDD1B 5.444873611 4.161655531 6.728091692 1.616686351 0.693039812 0.747994079 1 0.081087954 0.128900112 728780 ankyrin repeat and death domain containing 1B GO:0007165 signal transduction ANKEF1 164.7281916 173.7491184 155.7072649 0.896161467 -0.1581694 0.69700469 1 2.355861563 2.07590374 63926 ankyrin repeat and EF-hand domain containing 1 "GO:0005509,GO:0005515" calcium ion binding|protein binding ANKFN1 51.95652746 64.50566072 39.4073942 0.610913736 -0.710959416 0.230846195 1 0.271301801 0.162968529 162282 ankyrin repeat and fibronectin type III domain containing 1 ANKFY1 1728.734911 2147.414254 1310.055568 0.610061876 -0.712972519 0.002744041 0.345392232 14.34696444 8.606074202 51479 ankyrin repeat and FYVE domain containing 1 "GO:0005515,GO:0005765,GO:0005768,GO:0005769,GO:0005829,GO:0006897,GO:0010008,GO:0016020,GO:0016197,GO:0030904,GO:0031267,GO:0034058,GO:0042147,GO:0043231,GO:0044354,GO:0046872,GO:0048549,GO:0070062,GO:0090160,GO:1901981" "protein binding|lysosomal membrane|endosome|early endosome|cytosol|endocytosis|endosome membrane|membrane|endosomal transport|retromer complex|small GTPase binding|endosomal vesicle fusion|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|macropinosome|metal ion binding|positive regulation of pinocytosis|extracellular exosome|Golgi to lysosome transport|phosphatidylinositol phosphate binding" ANKH 636.0532293 675.2286098 596.8778487 0.883964097 -0.17794032 0.496268955 1 4.319274828 3.754193412 56172 ANKH inorganic pyrophosphate transport regulator "GO:0001501,GO:0005315,GO:0005886,GO:0005887,GO:0007626,GO:0015114,GO:0016021,GO:0019867,GO:0030500,GO:0030504,GO:0030505,GO:0035435,GO:0055085" skeletal system development|inorganic phosphate transmembrane transporter activity|plasma membrane|integral component of plasma membrane|locomotory behavior|phosphate ion transmembrane transporter activity|integral component of membrane|outer membrane|regulation of bone mineralization|inorganic diphosphate transmembrane transporter activity|inorganic diphosphate transport|phosphate ion transmembrane transport|transmembrane transport ANKHD1 47.04192163 36.41448589 57.66935736 1.583692752 0.663292469 0.28416177 1 0.230421412 0.358810332 54882 ankyrin repeat and KH domain containing 1 "GO:0003723,GO:0005515,GO:0005737,GO:0045087" RNA binding|protein binding|cytoplasm|innate immune response ANKHD1-EIF4EBP3 4.523346619 5.202069413 3.844623824 0.739056617 -0.436243205 0.933440272 1 0.033336321 0.024225155 404734 ANKHD1-EIF4EBP3 readthrough ANKIB1 2542.003142 2718.601475 2365.404808 0.870081485 -0.200777577 0.395922735 1 22.88434766 19.57805943 54467 ankyrin repeat and IBR domain containing 1 "GO:0000151,GO:0000209,GO:0005515,GO:0005737,GO:0006511,GO:0031624,GO:0032436,GO:0046872,GO:0061630" ubiquitin ligase complex|protein polyubiquitination|protein binding|cytoplasm|ubiquitin-dependent protein catabolic process|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity ANKK1 1.922311912 0 3.844623824 Inf Inf 0.288176591 1 0 0.030269631 255239 ankyrin repeat and kinase domain containing 1 "GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0010564,GO:0042995,GO:0106310,GO:0106311" protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|regulation of cell cycle process|cell projection|protein serine kinase activity|protein threonine kinase activity ANKLE1 9.487642252 9.363724944 9.61155956 1.026467524 0.037687984 1 1 0.17528053 0.176909058 126549 ankyrin repeat and LEM domain containing 1 "GO:0004519,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006281,GO:0006611,GO:0090305,GO:2001022" endonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA repair|protein export from nucleus|nucleic acid phosphodiester bond hydrolysis|positive regulation of response to DNA damage stimulus ANKLE2 2891.545649 2912.118458 2870.972841 0.985870899 -0.020529359 0.932368673 1 30.48536874 29.55171421 23141 ankyrin repeat and LEM domain containing 2 "GO:0005515,GO:0005783,GO:0005789,GO:0007084,GO:0007417,GO:0016020,GO:0019888,GO:0030176,GO:0035307,GO:0042326,GO:0043066,GO:0043666,GO:0050790,GO:0051301,GO:0051721" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|mitotic nuclear envelope reassembly|central nervous system development|membrane|protein phosphatase regulator activity|integral component of endoplasmic reticulum membrane|positive regulation of protein dephosphorylation|negative regulation of phosphorylation|negative regulation of apoptotic process|regulation of phosphoprotein phosphatase activity|regulation of catalytic activity|cell division|protein phosphatase 2A binding ANKMY1 162.637303 194.5573961 130.71721 0.671869652 -0.573746729 0.144646654 1 1.142388673 0.7546926 51281 ankyrin repeat and MYND domain containing 1 GO:0046872 metal ion binding ANKMY2 796.8581535 745.9767539 847.7395532 1.13641551 0.184490427 0.465326855 1 14.86054808 16.60516358 57037 ankyrin repeat and MYND domain containing 2 "GO:0005515,GO:0005929,GO:0019899,GO:0046872" protein binding|cilium|enzyme binding|metal ion binding ANKRA2 466.4104318 473.3883166 459.432547 0.970519404 -0.043171037 0.884169847 1 11.73971394 11.20296338 57763 ankyrin repeat family A member 2 "GO:0005515,GO:0005634,GO:0005829,GO:0005856,GO:0010468,GO:0016020,GO:0019901,GO:0031625,GO:0032991,GO:0042826,GO:0043254,GO:0050750,GO:1990393" protein binding|nucleus|cytosol|cytoskeleton|regulation of gene expression|membrane|protein kinase binding|ubiquitin protein ligase binding|protein-containing complex|histone deacetylase binding|regulation of protein-containing complex assembly|low-density lipoprotein particle receptor binding|3M complex ANKRD1 655.6292074 495.2370081 816.0214066 1.64773915 0.72048787 0.005495437 0.450000583 14.76530107 23.92224566 27063 ankyrin repeat domain 1 "GO:0000122,GO:0001085,GO:0001650,GO:0002039,GO:0003677,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006357,GO:0010976,GO:0019216,GO:0031432,GO:0031674,GO:0035690,GO:0035914,GO:0035994,GO:0042826,GO:0043065,GO:0043517,GO:0045214,GO:0045893,GO:0050714,GO:0055008,GO:0061629,GO:0070412,GO:0070528,GO:0071222,GO:0071260,GO:0071347,GO:0071356,GO:0071407,GO:0071456,GO:0071560,GO:2000279" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription factor binding|fibrillar center|p53 binding|DNA binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|positive regulation of neuron projection development|regulation of lipid metabolic process|titin binding|I band|cellular response to drug|skeletal muscle cell differentiation|response to muscle stretch|histone deacetylase binding|positive regulation of apoptotic process|positive regulation of DNA damage response, signal transduction by p53 class mediator|sarcomere organization|positive regulation of transcription, DNA-templated|positive regulation of protein secretion|cardiac muscle tissue morphogenesis|RNA polymerase II-specific DNA-binding transcription factor binding|R-SMAD binding|protein kinase C signaling|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to organic cyclic compound|cellular response to hypoxia|cellular response to transforming growth factor beta stimulus|negative regulation of DNA biosynthetic process" ANKRD10 3417.978024 3510.35644 3325.599608 0.947368071 -0.078003046 0.743111782 1 14.21945134 13.24563434 55608 ankyrin repeat domain 10 GO:0005515 protein binding ANKRD11 4168.089323 4580.942325 3755.23632 0.819751932 -0.286740699 0.229196086 1 19.74610068 15.91603825 29123 ankyrin repeat domain 11 "GO:0005634,GO:0005654,GO:0005829,GO:0009653,GO:0042475,GO:0048705,GO:0060325" nucleus|nucleoplasm|cytosol|anatomical structure morphogenesis|odontogenesis of dentin-containing tooth|skeletal system morphogenesis|face morphogenesis ANKRD12 758.7484543 805.2803452 712.2165634 0.884433064 -0.177175134 0.486087095 1 4.492612584 3.906925394 23253 ankyrin repeat domain 12 "GO:0005654,GO:0005829" nucleoplasm|cytosol ANKRD13A 1912.585498 1775.986498 2049.184498 1.153828872 0.20642927 0.383693107 1 23.09481853 26.20155913 88455 ankyrin repeat domain 13A "GO:0002091,GO:0005737,GO:0005770,GO:0005886,GO:0048471,GO:0140036,GO:1905667" negative regulation of receptor internalization|cytoplasm|late endosome|plasma membrane|perinuclear region of cytoplasm|ubiquitin-dependent protein binding|negative regulation of protein localization to endosome ANKRD13B 213.4892499 217.4465015 209.5319984 0.963602527 -0.053489917 0.893338362 1 2.606630758 2.469725152 124930 ankyrin repeat domain 13B "GO:0002091,GO:0005737,GO:0005769,GO:0005770,GO:0005886,GO:0043231,GO:0048471,GO:0140036" negative regulation of receptor internalization|cytoplasm|early endosome|late endosome|plasma membrane|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|ubiquitin-dependent protein binding ANKRD13C 614.9033822 586.7934298 643.0133346 1.095808681 0.131995938 0.617672337 1 6.207351213 6.688245929 81573 ankyrin repeat domain 13C "GO:0005102,GO:0005515,GO:0005737,GO:0005783,GO:0005789,GO:0006621,GO:0010469,GO:0048471,GO:2000209" signaling receptor binding|protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|protein retention in ER lumen|regulation of signaling receptor activity|perinuclear region of cytoplasm|regulation of anoikis ANKRD13D 782.891824 719.9664068 845.8172413 1.174800981 0.232416376 0.357926666 1 15.77310504 18.22018049 338692 ankyrin repeat domain 13D "GO:0002091,GO:0005737,GO:0005770,GO:0005886,GO:0048471,GO:0140036" negative regulation of receptor internalization|cytoplasm|late endosome|plasma membrane|perinuclear region of cytoplasm|ubiquitin-dependent protein binding ANKRD16 83.9866753 85.31393838 82.65941222 0.9688852 -0.04560236 0.952908748 1 1.660484351 1.58189731 54522 ankyrin repeat domain 16 "GO:0005634,GO:0005737,GO:0006400" nucleus|cytoplasm|tRNA modification ANKRD17 2327.061482 2627.045054 2027.077911 0.771619013 -0.374039403 0.113599219 1 9.99077647 7.580072181 26057 ankyrin repeat domain 17 "GO:0000785,GO:0001955,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006275,GO:0016020,GO:0016032,GO:0031965,GO:0042742,GO:0043123,GO:0045087,GO:0045787,GO:0051151,GO:1900087,GO:1900245,GO:1900246" chromatin|blood vessel maturation|chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of DNA replication|membrane|viral process|nuclear membrane|defense response to bacterium|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of cell cycle|negative regulation of smooth muscle cell differentiation|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of MDA-5 signaling pathway|positive regulation of RIG-I signaling pathway ANKRD18A 350.9282925 431.7717613 270.0848236 0.625526836 -0.676856316 0.024072812 0.848442542 2.754346801 1.694087142 253650 ankyrin repeat domain 18A ANKRD18B 297.312379 311.0837509 283.541007 0.911461965 -0.13374564 0.678770607 1 3.594277558 3.221227072 441459 ankyrin repeat domain 18B ANKRD20A1 19.41623352 17.687036 21.14543103 1.195532763 0.257653667 0.817588523 1 0.242342645 0.284880357 84210 ankyrin repeat domain 20 family member A1 GO:0005886 plasma membrane ANKRD23 41.5920176 44.73779695 38.44623824 0.85936816 -0.21865177 0.762676756 1 0.923983746 0.78075499 200539 ankyrin repeat domain 23 "GO:0005515,GO:0005654,GO:0005829,GO:0009612,GO:0014704,GO:0015629,GO:0030016,GO:0031432" protein binding|nucleoplasm|cytosol|response to mechanical stimulus|intercalated disc|actin cytoskeleton|myofibril|titin binding ANKRD24 5.603389465 8.323311061 2.883467868 0.346432789 -1.529352609 0.352439314 1 0.08063166 0.027466022 170961 ankyrin repeat domain 24 ANKRD26 312.4826686 330.8516147 294.1137225 0.888959611 -0.169810223 0.590123753 1 0.540695204 0.472613068 22852 ankyrin repeat domain 26 "GO:0005515,GO:0005813,GO:0045599" protein binding|centrosome|negative regulation of fat cell differentiation ANKRD27 1232.888377 1178.788929 1286.987825 1.091788185 0.12669299 0.601759381 1 14.13068253 15.16955036 84079 ankyrin repeat domain 27 "GO:0000149,GO:0005085,GO:0005096,GO:0005515,GO:0005764,GO:0005769,GO:0005770,GO:0005829,GO:0005886,GO:0010976,GO:0015031,GO:0016020,GO:0030133,GO:0030659,GO:0031267,GO:0035544,GO:0035646,GO:0042470,GO:0043005,GO:0043547,GO:0045022,GO:0048812,GO:0050775,GO:0097422,GO:1990126" "SNARE binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|lysosome|early endosome|late endosome|cytosol|plasma membrane|positive regulation of neuron projection development|protein transport|membrane|transport vesicle|cytoplasmic vesicle membrane|small GTPase binding|negative regulation of SNARE complex assembly|endosome to melanosome transport|melanosome|neuron projection|positive regulation of GTPase activity|early endosome to late endosome transport|neuron projection morphogenesis|positive regulation of dendrite morphogenesis|tubular endosome|retrograde transport, endosome to plasma membrane" ANKRD28 2605.632549 2736.288511 2474.976587 0.904501326 -0.144805477 0.540755219 1 15.24169594 13.5554419 23243 ankyrin repeat domain 28 "GO:0000139,GO:0005515,GO:0005654,GO:0005829,GO:0048208" Golgi membrane|protein binding|nucleoplasm|cytosol|COPII vesicle coating ANKRD29 362.9131738 405.7614142 320.0649333 0.788800813 -0.342267057 0.249982162 1 3.576340367 2.773814236 147463 ankyrin repeat domain 29 GO:0005515 protein binding ANKRD30B 17.13223052 20.80827765 13.45618338 0.64667454 -0.628888283 0.513000638 1 0.240315848 0.152805629 374860 ankyrin repeat domain 30B "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process ANKRD31 6.004709516 6.242483296 5.766935736 0.923820772 -0.11431511 1 1 0.051261711 0.046564184 256006 ankyrin repeat domain 31 "GO:0000785,GO:0005634,GO:0007129,GO:0010780,GO:1903343" chromatin|nucleus|homologous chromosome pairing at meiosis|meiotic DNA double-strand break formation involved in reciprocal meiotic recombination|positive regulation of meiotic DNA double-strand break formation ANKRD33B 548.5389618 598.2379825 498.8399412 0.833848662 -0.262142527 0.328461683 1 3.30095757 2.706439708 651746 ankyrin repeat domain 33B ANKRD34A 94.36627641 67.62690237 121.1056505 1.790791034 0.840597001 0.078963417 1 1.000588713 1.761861191 284615 ankyrin repeat domain 34A ANKRD36 445.1612051 432.8121752 457.5102351 1.057064152 0.080062935 0.782555148 1 2.473061061 2.570439362 375248 ankyrin repeat domain 36 ANKRD36B 136.547698 140.4558742 132.6395219 0.944350122 -0.08260625 0.860567169 1 0.858928825 0.797556387 57730 ankyrin repeat domain 36B GO:0005515 protein binding ANKRD36C 292.957609 285.0734038 300.8418142 1.055313509 0.077671654 0.816070288 1 1.857158645 1.927088592 400986 ankyrin repeat domain 36C GO:0008200 ion channel inhibitor activity ANKRD37 40.15531408 32.25283036 48.0577978 1.490033503 0.575344769 0.385748895 1 2.195502906 3.21663089 353322 ankyrin repeat domain 37 "GO:0005515,GO:0005654,GO:0005739,GO:0005829" protein binding|nucleoplasm|mitochondrion|cytosol ANKRD39 216.0607165 196.6382238 235.4832092 1.197545445 0.260080405 0.466029347 1 11.7648213 13.85314936 51239 ankyrin repeat domain 39 "GO:0003674,GO:0004842,GO:0005575,GO:0008150,GO:0031436,GO:0070531,GO:0085020" molecular_function|ubiquitin-protein transferase activity|cellular_component|biological_process|BRCA1-BARD1 complex|BRCA1-A complex|protein K6-linked ubiquitination ANKRD40 1489.895758 1630.328554 1349.462962 0.827724546 -0.272777354 0.253253556 1 20.21083357 16.44906583 91369 ankyrin repeat domain 40 "GO:0003674,GO:0005515,GO:0005575,GO:0008150" molecular_function|protein binding|cellular_component|biological_process ANKRD42 522.4097279 543.0960467 501.723409 0.923820772 -0.11431511 0.677375352 1 4.74137704 4.306886173 338699 ankyrin repeat domain 42 ANKRD44 317.3777671 307.9625093 326.793025 1.061145481 0.085622461 0.790605667 1 1.544244396 1.611247073 91526 ankyrin repeat domain 44 GO:0005515 protein binding ANKRD45 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.035650065 0.01619158 339416 ankyrin repeat domain 45 "GO:0003674,GO:0005515,GO:0005575,GO:0008150" molecular_function|protein binding|cellular_component|biological_process ANKRD46 151.3216981 149.8195991 152.823797 1.020052102 0.028642844 0.961582167 1 1.852977207 1.858504474 157567 ankyrin repeat domain 46 GO:0016021 integral component of membrane ANKRD49 314.370382 317.3262342 311.4145297 0.981370262 -0.027130539 0.941280863 1 8.459099849 8.162594528 54851 ankyrin repeat domain 49 "GO:0005515,GO:0005634,GO:0007283,GO:0030154,GO:0045893" "protein binding|nucleus|spermatogenesis|cell differentiation|positive regulation of transcription, DNA-templated" ANKRD50 1342.404821 1316.123562 1368.686081 1.039937375 0.056496651 0.816693589 1 7.162869218 7.324287563 57182 ankyrin repeat domain 50 "GO:0005515,GO:0005768,GO:0015031,GO:1990126" "protein binding|endosome|protein transport|retrograde transport, endosome to plasma membrane" ANKRD52 2608.270025 2452.255521 2764.284529 1.127241637 0.172796807 0.465255914 1 14.66521404 16.25461198 283373 ankyrin repeat domain 52 GO:0005515 protein binding ANKRD53 3.081612685 5.202069413 0.961155956 0.184764154 -2.436243205 0.338470402 1 0.130955134 0.02379093 79998 ankyrin repeat domain 53 "GO:0000922,GO:0005515,GO:0005737,GO:0005819,GO:0007080,GO:0031116,GO:0051301,GO:0060236,GO:1902412" spindle pole|protein binding|cytoplasm|spindle|mitotic metaphase plate congression|positive regulation of microtubule polymerization|cell division|regulation of mitotic spindle organization|regulation of mitotic cytokinesis ANKRD54 445.280092 435.9334168 454.6267672 1.042881205 0.06057483 0.836795784 1 6.668089781 6.837659308 129138 ankyrin repeat domain 54 "GO:0005515,GO:0005634,GO:0005737,GO:0006913,GO:0019887,GO:0030496,GO:0044877,GO:0045648,GO:0045859,GO:1902531" protein binding|nucleus|cytoplasm|nucleocytoplasmic transport|protein kinase regulator activity|midbody|protein-containing complex binding|positive regulation of erythrocyte differentiation|regulation of protein kinase activity|regulation of intracellular signal transduction ANKRD6 409.1625161 421.3676225 396.9574098 0.942069083 -0.086095236 0.771472584 1 2.816937939 2.609343228 22881 ankyrin repeat domain 6 "GO:0005634,GO:0005737,GO:0043231,GO:0046330,GO:0090090,GO:2000096" "nucleus|cytoplasm|intracellular membrane-bounded organelle|positive regulation of JNK cascade|negative regulation of canonical Wnt signaling pathway|positive regulation of Wnt signaling pathway, planar cell polarity pathway" ANKRD61 12.56925494 14.56579436 10.57271552 0.725859178 -0.462238413 0.707585678 1 0.546275245 0.389883694 100310846 ankyrin repeat domain 61 GO:0005654 nucleoplasm ANKRD9 751.0006848 652.3395044 849.6618651 1.30248415 0.381265817 0.132893202 1 4.712895682 6.035752913 122416 ankyrin repeat domain 9 "GO:0005829,GO:0043687" cytosol|post-translational protein modification ANKS1A 497.8656525 529.5706663 466.1606387 0.880261443 -0.183996019 0.504057897 1 2.381981723 2.061680118 23294 ankyrin repeat and sterile alpha motif domain containing 1A "GO:0005515,GO:0005654,GO:0005829,GO:0006929,GO:0016322,GO:0043005,GO:0046875,GO:0048013,GO:1901187" protein binding|nucleoplasm|cytosol|substrate-dependent cell migration|neuron remodeling|neuron projection|ephrin receptor binding|ephrin receptor signaling pathway|regulation of ephrin receptor signaling pathway ANKS1B 27.94271981 27.05076095 28.83467868 1.065947044 0.092135768 0.954076963 1 0.079013157 0.082814469 56899 ankyrin repeat and sterile alpha motif domain containing 1B "GO:0005829,GO:0005886,GO:0014069,GO:0015030,GO:0043197,GO:0043231,GO:0046875,GO:0048013,GO:1900383" cytosol|plasma membrane|postsynaptic density|Cajal body|dendritic spine|intracellular membrane-bounded organelle|ephrin receptor binding|ephrin receptor signaling pathway|regulation of synaptic plasticity by receptor localization to synapse ANKS3 194.5139654 198.7190516 190.3088793 0.957678078 -0.062387318 0.878856517 1 3.677278278 3.462718768 124401 ankyrin repeat and sterile alpha motif domain containing 3 "GO:0005515,GO:0005737,GO:0005929" protein binding|cytoplasm|cilium ANKS4B 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.038532253 0.023334153 257629 ankyrin repeat and sterile alpha motif domain containing 4B "GO:0005515,GO:0005789,GO:0005886,GO:0005902,GO:0005903,GO:0030154,GO:0034622,GO:0034976,GO:1904106,GO:1904970" protein binding|endoplasmic reticulum membrane|plasma membrane|microvillus|brush border|cell differentiation|cellular protein-containing complex assembly|response to endoplasmic reticulum stress|protein localization to microvillus|brush border assembly ANKS6 762.2458639 871.8668337 652.6248941 0.748537356 -0.417853779 0.098694577 1 9.259687659 6.815237499 203286 ankyrin repeat and sterile alpha motif domain containing 6 "GO:0001701,GO:0001822,GO:0005515,GO:0005737,GO:0007368,GO:0007507,GO:0097543" in utero embryonic development|kidney development|protein binding|cytoplasm|determination of left/right symmetry|heart development|ciliary inversin compartment ANKZF1 842.3589616 830.2502783 854.4676449 1.029168754 0.041479563 0.872889485 1 18.03375312 18.24920254 55139 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 "GO:0005515,GO:0005737,GO:0016020,GO:0030433,GO:0046872,GO:0070301" protein binding|cytoplasm|membrane|ubiquitin-dependent ERAD pathway|metal ion binding|cellular response to hydrogen peroxide ANLN 7101.62758 6841.761692 7361.493467 1.075964612 0.10563063 0.66614203 1 75.47173355 79.84606026 54443 anillin actin binding protein "GO:0000281,GO:0000915,GO:0000921,GO:0003779,GO:0005654,GO:0005826,GO:0007096,GO:0015629,GO:0030496,GO:0031106,GO:0032059,GO:0045296,GO:0090521,GO:0099738,GO:1904172" mitotic cytokinesis|actomyosin contractile ring assembly|septin ring assembly|actin binding|nucleoplasm|actomyosin contractile ring|regulation of exit from mitosis|actin cytoskeleton|midbody|septin ring organization|bleb|cadherin binding|glomerular visceral epithelial cell migration|cell cortex region|positive regulation of bleb assembly ANO10 982.9248906 937.4129083 1028.436873 1.097101249 0.133696676 0.589226987 1 10.11075263 10.90690106 55129 anoctamin 10 "GO:0005227,GO:0005229,GO:0005886,GO:0006812,GO:0006821,GO:0016020,GO:0016021,GO:0034220,GO:0043231,GO:0055085,GO:0098655,GO:1902476" calcium activated cation channel activity|intracellular calcium activated chloride channel activity|plasma membrane|cation transport|chloride transport|membrane|integral component of membrane|ion transmembrane transport|intracellular membrane-bounded organelle|transmembrane transport|cation transmembrane transport|chloride transmembrane transport ANO4 3.081612685 5.202069413 0.961155956 0.184764154 -2.436243205 0.338470402 1 0.032731064 0.00594633 121601 anoctamin 4 "GO:0005229,GO:0005254,GO:0005886,GO:0006821,GO:0016021,GO:0034220,GO:0046983,GO:0055085,GO:0061588,GO:1902476" intracellular calcium activated chloride channel activity|chloride channel activity|plasma membrane|chloride transport|integral component of membrane|ion transmembrane transport|protein dimerization activity|transmembrane transport|calcium activated phospholipid scrambling|chloride transmembrane transport ANO6 3967.711499 4026.401726 3909.021273 0.970847307 -0.042683685 0.858640751 1 29.79501662 28.44236733 196527 anoctamin 6 "GO:0002407,GO:0002543,GO:0005227,GO:0005229,GO:0005244,GO:0005247,GO:0005254,GO:0005515,GO:0005829,GO:0005886,GO:0006812,GO:0006821,GO:0007596,GO:0009986,GO:0016020,GO:0017121,GO:0017128,GO:0030501,GO:0032060,GO:0034220,GO:0034707,GO:0034767,GO:0035579,GO:0035590,GO:0035725,GO:0043065,GO:0043312,GO:0045794,GO:0046872,GO:0046931,GO:0046983,GO:0055085,GO:0060100,GO:0061589,GO:0061590,GO:0070062,GO:0070588,GO:0070821,GO:0090026,GO:0097045,GO:1902476,GO:1903766,GO:2000353" "dendritic cell chemotaxis|activation of blood coagulation via clotting cascade|calcium activated cation channel activity|intracellular calcium activated chloride channel activity|voltage-gated ion channel activity|voltage-gated chloride channel activity|chloride channel activity|protein binding|cytosol|plasma membrane|cation transport|chloride transport|blood coagulation|cell surface|membrane|plasma membrane phospholipid scrambling|phospholipid scramblase activity|positive regulation of bone mineralization|bleb assembly|ion transmembrane transport|chloride channel complex|positive regulation of ion transmembrane transport|specific granule membrane|purinergic nucleotide receptor signaling pathway|sodium ion transmembrane transport|positive regulation of apoptotic process|neutrophil degranulation|negative regulation of cell volume|metal ion binding|pore complex assembly|protein dimerization activity|transmembrane transport|positive regulation of phagocytosis, engulfment|calcium activated phosphatidylserine scrambling|calcium activated phosphatidylcholine scrambling|extracellular exosome|calcium ion transmembrane transport|tertiary granule membrane|positive regulation of monocyte chemotaxis|phosphatidylserine exposure on blood platelet|chloride transmembrane transport|positive regulation of potassium ion export across plasma membrane|positive regulation of endothelial cell apoptotic process" ANO7 61.60268556 78.0310412 45.17432993 0.578927684 -0.788544949 0.156183366 1 0.800379253 0.455607976 50636 anoctamin 7 "GO:0005229,GO:0005254,GO:0005783,GO:0005829,GO:0005886,GO:0006821,GO:0016021,GO:0017128,GO:0030054,GO:0034220,GO:0046983,GO:0055085,GO:0061588,GO:0061589,GO:0061590,GO:0061591,GO:1902476" intracellular calcium activated chloride channel activity|chloride channel activity|endoplasmic reticulum|cytosol|plasma membrane|chloride transport|integral component of membrane|phospholipid scramblase activity|cell junction|ion transmembrane transport|protein dimerization activity|transmembrane transport|calcium activated phospholipid scrambling|calcium activated phosphatidylserine scrambling|calcium activated phosphatidylcholine scrambling|calcium activated galactosylceramide scrambling|chloride transmembrane transport ANO8 346.5294775 316.2858203 376.7731347 1.191242574 0.252467221 0.404550872 1 3.383361981 3.962961468 57719 anoctamin 8 "GO:0005229,GO:0005788,GO:0005886,GO:0006821,GO:0016021,GO:0034220,GO:0043687,GO:0044267,GO:0055085,GO:1902476" intracellular calcium activated chloride channel activity|endoplasmic reticulum lumen|plasma membrane|chloride transport|integral component of membrane|ion transmembrane transport|post-translational protein modification|cellular protein metabolic process|transmembrane transport|chloride transmembrane transport ANO9 182.0340293 161.2641518 202.8039067 1.257588276 0.330659674 0.383815048 1 1.762156304 2.178984228 338440 anoctamin 9 "GO:0005229,GO:0005254,GO:0005515,GO:0005886,GO:0006821,GO:0016021,GO:0017128,GO:0034220,GO:0055085,GO:0061589,GO:0061590,GO:0061591,GO:1902476,GO:1902939" intracellular calcium activated chloride channel activity|chloride channel activity|protein binding|plasma membrane|chloride transport|integral component of membrane|phospholipid scramblase activity|ion transmembrane transport|transmembrane transport|calcium activated phosphatidylserine scrambling|calcium activated phosphatidylcholine scrambling|calcium activated galactosylceramide scrambling|chloride transmembrane transport|negative regulation of intracellular calcium activated chloride channel activity ANOS1 295.6033031 278.8309205 312.3756857 1.12030504 0.163891608 0.610273458 1 2.231992464 2.458669719 3730 anosmin 1 "GO:0004867,GO:0005201,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0006935,GO:0007155,GO:0007411,GO:0008201,GO:0008543,GO:0009986,GO:0010951,GO:0030182,GO:0031012" serine-type endopeptidase inhibitor activity|extracellular matrix structural constituent|protein binding|extracellular region|extracellular space|plasma membrane|chemotaxis|cell adhesion|axon guidance|heparin binding|fibroblast growth factor receptor signaling pathway|cell surface|negative regulation of endopeptidase activity|neuron differentiation|extracellular matrix ANP32A 2225.271342 2099.555215 2350.987468 1.119755009 0.16318312 0.490562465 1 45.92188648 50.56079721 8125 acidic nuclear phosphoprotein 32 family member A "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0006913,GO:0035556,GO:0042393,GO:0042981,GO:0043488,GO:0048471" RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|nucleocytoplasmic transport|intracellular signal transduction|histone binding|regulation of apoptotic process|regulation of mRNA stability|perinuclear region of cytoplasm ANP32B 5021.973938 5133.402097 4910.545779 0.956587013 -0.06403189 0.790281986 1 184.7338066 173.7568914 10541 acidic nuclear phosphoprotein 32 family member B "GO:0001944,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006334,GO:0006919,GO:0021591,GO:0042393,GO:0042981,GO:0045596,GO:0046827,GO:0048839,GO:0060021,GO:0070062,GO:0070063" vasculature development|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|nucleosome assembly|activation of cysteine-type endopeptidase activity involved in apoptotic process|ventricular system development|histone binding|regulation of apoptotic process|negative regulation of cell differentiation|positive regulation of protein export from nucleus|inner ear development|roof of mouth development|extracellular exosome|RNA polymerase binding ANP32C 5.965080553 5.202069413 6.728091692 1.29334908 0.371111717 0.919461532 1 0.282713731 0.359528927 23520 acidic nuclear phosphoprotein 32 family member C "GO:0005634,GO:0006913,GO:0042393,GO:0042981,GO:0048471" nucleus|nucleocytoplasmic transport|histone binding|regulation of apoptotic process|perinuclear region of cytoplasm ANP32E 1612.640673 1736.45077 1488.830576 0.857398667 -0.22196192 0.351117037 1 25.87135291 21.81087671 81611 acidic nuclear phosphoprotein 32 family member E "GO:0000812,GO:0005515,GO:0005634,GO:0019212,GO:0031410,GO:0042393,GO:0042981,GO:0043086,GO:0043486" Swr1 complex|protein binding|nucleus|phosphatase inhibitor activity|cytoplasmic vesicle|histone binding|regulation of apoptotic process|negative regulation of catalytic activity|histone exchange ANTKMT 116.4527417 117.5667687 115.3387147 0.981048607 -0.027603477 0.971908014 1 7.211864792 6.956796188 65990 adenine nucleotide translocase lysine methyltransferase "GO:0005515,GO:0005739,GO:0016021,GO:0016279,GO:0018023,GO:0031966,GO:1905273,GO:1905706" "protein binding|mitochondrion|integral component of membrane|protein-lysine N-methyltransferase activity|peptidyl-lysine trimethylation|mitochondrial membrane|positive regulation of proton-transporting ATP synthase activity, rotational mechanism|regulation of mitochondrial ATP synthesis coupled proton transport" ANTXR1 2479.364458 2726.924786 2231.80413 0.818432595 -0.289064491 0.221393502 1 12.25523907 9.862247194 84168 ANTXR cell adhesion molecule 1 "GO:0001568,GO:0004888,GO:0005515,GO:0005518,GO:0005886,GO:0009897,GO:0009986,GO:0010008,GO:0016021,GO:0022414,GO:0031258,GO:0031527,GO:0031532,GO:0034446,GO:0046872,GO:0051015,GO:1901202,GO:1901998,GO:1905050" blood vessel development|transmembrane signaling receptor activity|protein binding|collagen binding|plasma membrane|external side of plasma membrane|cell surface|endosome membrane|integral component of membrane|reproductive process|lamellipodium membrane|filopodium membrane|actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading|metal ion binding|actin filament binding|negative regulation of extracellular matrix assembly|toxin transport|positive regulation of metallopeptidase activity hsa04621 NOD-like receptor signaling pathway ANTXR2 1767.215632 1366.063428 2168.367837 1.587311242 0.666585042 0.00507179 0.430157521 7.344040942 11.46220998 118429 ANTXR cell adhesion molecule 2 "GO:0004888,GO:0005515,GO:0005576,GO:0005789,GO:0005886,GO:0009986,GO:0010008,GO:0016021,GO:0046872,GO:1901998" transmembrane signaling receptor activity|protein binding|extracellular region|endoplasmic reticulum membrane|plasma membrane|cell surface|endosome membrane|integral component of membrane|metal ion binding|toxin transport hsa04621 NOD-like receptor signaling pathway ANXA1 8663.034992 7712.588112 9613.481872 1.246466391 0.317843984 0.200579765 1 247.6574323 303.5310452 301 annexin A1 "GO:0001533,GO:0001780,GO:0001891,GO:0002250,GO:0002548,GO:0002685,GO:0003697,GO:0003727,GO:0005102,GO:0005509,GO:0005515,GO:0005543,GO:0005544,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005829,GO:0005884,GO:0005886,GO:0005912,GO:0005925,GO:0006909,GO:0006954,GO:0007165,GO:0007166,GO:0007186,GO:0007187,GO:0008360,GO:0009986,GO:0010165,GO:0014839,GO:0016323,GO:0016324,GO:0016328,GO:0018149,GO:0019221,GO:0019834,GO:0019898,GO:0030073,GO:0030216,GO:0030659,GO:0030850,GO:0031018,GO:0031232,GO:0031313,GO:0031340,GO:0031394,GO:0031514,GO:0031532,GO:0031901,GO:0031966,GO:0031982,GO:0032355,GO:0032508,GO:0032652,GO:0032717,GO:0032743,GO:0032991,GO:0033031,GO:0035924,GO:0036121,GO:0042063,GO:0042102,GO:0042383,GO:0042493,GO:0042629,GO:0042802,GO:0043066,GO:0043434,GO:0044849,GO:0045087,GO:0045627,GO:0045629,GO:0045920,GO:0046632,GO:0046883,GO:0048306,GO:0050482,GO:0050709,GO:0050727,GO:0062023,GO:0070062,GO:0070301,GO:0070365,GO:0070459,GO:0070555,GO:0071385,GO:0071621,GO:0090050,GO:0090303,GO:0097060,GO:0097350,GO:0098609,GO:0098641,GO:1900087,GO:1900138,GO:1990814" "cornified envelope|neutrophil homeostasis|phagocytic cup|adaptive immune response|monocyte chemotaxis|regulation of leukocyte migration|single-stranded DNA binding|single-stranded RNA binding|signaling receptor binding|calcium ion binding|protein binding|phospholipid binding|calcium-dependent phospholipid binding|extracellular region|extracellular space|nucleus|nucleoplasm|cytoplasm|endosome|cytosol|actin filament|plasma membrane|adherens junction|focal adhesion|phagocytosis|inflammatory response|signal transduction|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|regulation of cell shape|cell surface|response to X-ray|myoblast migration involved in skeletal muscle regeneration|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|peptide cross-linking|cytokine-mediated signaling pathway|phospholipase A2 inhibitor activity|extrinsic component of membrane|insulin secretion|keratinocyte differentiation|cytoplasmic vesicle membrane|prostate gland development|endocrine pancreas development|extrinsic component of external side of plasma membrane|extrinsic component of endosome membrane|positive regulation of vesicle fusion|positive regulation of prostaglandin biosynthetic process|motile cilium|actin cytoskeleton reorganization|early endosome membrane|mitochondrial membrane|vesicle|response to estradiol|DNA duplex unwinding|regulation of interleukin-1 production|negative regulation of interleukin-8 production|positive regulation of interleukin-2 production|protein-containing complex|positive regulation of neutrophil apoptotic process|cellular response to vascular endothelial growth factor stimulus|double-stranded DNA helicase activity|gliogenesis|positive regulation of T cell proliferation|sarcolemma|response to drug|mast cell granule|identical protein binding|negative regulation of apoptotic process|response to peptide hormone|estrous cycle|innate immune response|positive regulation of T-helper 1 cell differentiation|negative regulation of T-helper 2 cell differentiation|negative regulation of exocytosis|alpha-beta T cell differentiation|regulation of hormone secretion|calcium-dependent protein binding|arachidonic acid secretion|negative regulation of protein secretion|regulation of inflammatory response|collagen-containing extracellular matrix|extracellular exosome|cellular response to hydrogen peroxide|hepatocyte differentiation|prolactin secretion|response to interleukin-1|cellular response to glucocorticoid stimulus|granulocyte chemotaxis|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of wound healing|synaptic membrane|neutrophil clearance|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|positive regulation of G1/S transition of mitotic cell cycle|negative regulation of phospholipase A2 activity|DNA/DNA annealing activity" ANXA10 54.23550004 73.86938567 34.60161442 0.468416166 -1.094137228 0.06049636 1 2.605600361 1.200081827 11199 annexin A10 "GO:0005509,GO:0005515,GO:0005544,GO:0005737" calcium ion binding|protein binding|calcium-dependent phospholipid binding|cytoplasm ANXA11 5188.820014 4921.157665 5456.482362 1.108780237 0.148973448 0.535721008 1 30.28867949 33.02151502 311 annexin A11 "GO:0003723,GO:0005509,GO:0005515,GO:0005544,GO:0005635,GO:0005654,GO:0005737,GO:0005819,GO:0005829,GO:0006909,GO:0016020,GO:0023026,GO:0030496,GO:0032506,GO:0042470,GO:0042581,GO:0042582,GO:0044548,GO:0045335,GO:0048306,GO:0051592,GO:0062023,GO:0070062" RNA binding|calcium ion binding|protein binding|calcium-dependent phospholipid binding|nuclear envelope|nucleoplasm|cytoplasm|spindle|cytosol|phagocytosis|membrane|MHC class II protein complex binding|midbody|cytokinetic process|melanosome|specific granule|azurophil granule|S100 protein binding|phagocytic vesicle|calcium-dependent protein binding|response to calcium ion|collagen-containing extracellular matrix|extracellular exosome hsa05014 Amyotrophic lateral sclerosis ANXA2 29309.94385 21435.64722 37184.24047 1.734691753 0.794679325 0.006909375 0.502583554 218.8599761 373.3015903 302 annexin A2 "GO:0001525,GO:0001765,GO:0001786,GO:0001921,GO:0002020,GO:0003723,GO:0004867,GO:0005262,GO:0005509,GO:0005515,GO:0005544,GO:0005546,GO:0005576,GO:0005604,GO:0005615,GO:0005634,GO:0005737,GO:0005765,GO:0005768,GO:0005811,GO:0005886,GO:0005912,GO:0006900,GO:0008092,GO:0009986,GO:0010951,GO:0016020,GO:0016032,GO:0016323,GO:0019834,GO:0030496,GO:0031340,GO:0031902,GO:0031982,GO:0032804,GO:0035578,GO:0035722,GO:0036035,GO:0042470,GO:0042802,GO:0043312,GO:0044090,GO:0044147,GO:0044548,GO:0045121,GO:0046790,GO:0048306,GO:0052362,GO:0052405,GO:0062023,GO:0070062,GO:0070588,GO:0098609,GO:0098641,GO:1905581,GO:1905597,GO:1905599,GO:1905602,GO:1990665,GO:1990667" "angiogenesis|membrane raft assembly|phosphatidylserine binding|positive regulation of receptor recycling|protease binding|RNA binding|serine-type endopeptidase inhibitor activity|calcium channel activity|calcium ion binding|protein binding|calcium-dependent phospholipid binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular region|basement membrane|extracellular space|nucleus|cytoplasm|lysosomal membrane|endosome|lipid droplet|plasma membrane|adherens junction|vesicle budding from membrane|cytoskeletal protein binding|cell surface|negative regulation of endopeptidase activity|membrane|viral process|basolateral plasma membrane|phospholipase A2 inhibitor activity|midbody|positive regulation of vesicle fusion|late endosome membrane|vesicle|negative regulation of low-density lipoprotein particle receptor catabolic process|azurophil granule lumen|interleukin-12-mediated signaling pathway|osteoclast development|melanosome|identical protein binding|neutrophil degranulation|positive regulation of vacuole organization|negative regulation of development of symbiont involved in interaction with host|S100 protein binding|membrane raft|virion binding|calcium-dependent protein binding|catabolism by host of symbiont protein|negative regulation by host of symbiont molecular function|collagen-containing extracellular matrix|extracellular exosome|calcium ion transmembrane transport|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|positive regulation of low-density lipoprotein particle clearance|positive regulation of low-density lipoprotein particle receptor binding|positive regulation of low-density lipoprotein receptor activity|positive regulation of receptor-mediated endocytosis involved in cholesterol transport|AnxA2-p11 complex|PCSK9-AnxA2 complex" hsa05132 Salmonella infection ANXA2R 67.73634281 62.42483296 73.04785266 1.170172978 0.226721808 0.692008657 1 2.919805962 3.359504557 389289 annexin A2 receptor "GO:0005515,GO:0038023" protein binding|signaling receptor activity ANXA3 2611.094357 2400.234827 2821.953887 1.175699084 0.233518854 0.32346144 1 89.45259866 103.4094718 306 annexin A3 "GO:0005509,GO:0005544,GO:0005737,GO:0005886,GO:0006909,GO:0010595,GO:0016020,GO:0019834,GO:0021766,GO:0030424,GO:0030425,GO:0030670,GO:0031100,GO:0042581,GO:0042742,GO:0043025,GO:0043086,GO:0043312,GO:0045766,GO:0048306,GO:0051054,GO:0051091,GO:0051384,GO:0070062,GO:0070848" calcium ion binding|calcium-dependent phospholipid binding|cytoplasm|plasma membrane|phagocytosis|positive regulation of endothelial cell migration|membrane|phospholipase A2 inhibitor activity|hippocampus development|axon|dendrite|phagocytic vesicle membrane|animal organ regeneration|specific granule|defense response to bacterium|neuronal cell body|negative regulation of catalytic activity|neutrophil degranulation|positive regulation of angiogenesis|calcium-dependent protein binding|positive regulation of DNA metabolic process|positive regulation of DNA-binding transcription factor activity|response to glucocorticoid|extracellular exosome|response to growth factor ANXA4 944.394364 947.8170471 940.9716809 0.992777756 -0.010457304 0.971006934 1 7.087467254 6.91853722 307 annexin A4 "GO:0004859,GO:0005509,GO:0005515,GO:0005544,GO:0005634,GO:0005737,GO:0005886,GO:0006357,GO:0007165,GO:0007219,GO:0009986,GO:0012506,GO:0030855,GO:0031965,GO:0032088,GO:0032717,GO:0042802,GO:0043066,GO:0043086,GO:0048306,GO:0048471,GO:0051059,GO:0062023,GO:0070062" phospholipase inhibitor activity|calcium ion binding|protein binding|calcium-dependent phospholipid binding|nucleus|cytoplasm|plasma membrane|regulation of transcription by RNA polymerase II|signal transduction|Notch signaling pathway|cell surface|vesicle membrane|epithelial cell differentiation|nuclear membrane|negative regulation of NF-kappaB transcription factor activity|negative regulation of interleukin-8 production|identical protein binding|negative regulation of apoptotic process|negative regulation of catalytic activity|calcium-dependent protein binding|perinuclear region of cytoplasm|NF-kappaB binding|collagen-containing extracellular matrix|extracellular exosome ANXA5 12597.49914 11459.1185 13735.87977 1.19868555 0.261453248 0.309523325 1 234.042133 275.8484171 308 annexin A5 "GO:0002576,GO:0004859,GO:0005509,GO:0005515,GO:0005543,GO:0005544,GO:0005576,GO:0005737,GO:0005829,GO:0005925,GO:0007165,GO:0007596,GO:0016020,GO:0043066,GO:0043086,GO:0050819,GO:0062023,GO:0070062" platelet degranulation|phospholipase inhibitor activity|calcium ion binding|protein binding|phospholipid binding|calcium-dependent phospholipid binding|extracellular region|cytoplasm|cytosol|focal adhesion|signal transduction|blood coagulation|membrane|negative regulation of apoptotic process|negative regulation of catalytic activity|negative regulation of coagulation|collagen-containing extracellular matrix|extracellular exosome ANXA6 7732.998831 6712.750371 8753.247291 1.303973306 0.382914336 0.119991482 1 117.8057053 151.0449477 309 annexin A6 "GO:0001755,GO:0001778,GO:0001786,GO:0003418,GO:0005262,GO:0005509,GO:0005515,GO:0005525,GO:0005544,GO:0005737,GO:0005739,GO:0005765,GO:0005925,GO:0006937,GO:0008289,GO:0015276,GO:0015485,GO:0016020,GO:0031902,GO:0034220,GO:0035374,GO:0042470,GO:0042802,GO:0048306,GO:0048471,GO:0051015,GO:0051283,GO:0051560,GO:0062023,GO:0070062,GO:0070588,GO:0097190" neural crest cell migration|plasma membrane repair|phosphatidylserine binding|growth plate cartilage chondrocyte differentiation|calcium channel activity|calcium ion binding|protein binding|GTP binding|calcium-dependent phospholipid binding|cytoplasm|mitochondrion|lysosomal membrane|focal adhesion|regulation of muscle contraction|lipid binding|ligand-gated ion channel activity|cholesterol binding|membrane|late endosome membrane|ion transmembrane transport|chondroitin sulfate binding|melanosome|identical protein binding|calcium-dependent protein binding|perinuclear region of cytoplasm|actin filament binding|negative regulation of sequestering of calcium ion|mitochondrial calcium ion homeostasis|collagen-containing extracellular matrix|extracellular exosome|calcium ion transmembrane transport|apoptotic signaling pathway ANXA7 4438.91765 4524.759976 4353.075325 0.962056628 -0.055806279 0.816053814 1 94.14351803 89.05580586 310 annexin A7 "GO:0003723,GO:0005178,GO:0005509,GO:0005515,GO:0005544,GO:0005634,GO:0005737,GO:0005789,GO:0006914,GO:0010629,GO:0014070,GO:0016020,GO:0030855,GO:0042584,GO:0048306,GO:0051592,GO:0061025,GO:0062023,GO:0070062" RNA binding|integrin binding|calcium ion binding|protein binding|calcium-dependent phospholipid binding|nucleus|cytoplasm|endoplasmic reticulum membrane|autophagy|negative regulation of gene expression|response to organic cyclic compound|membrane|epithelial cell differentiation|chromaffin granule membrane|calcium-dependent protein binding|response to calcium ion|membrane fusion|collagen-containing extracellular matrix|extracellular exosome hsa05014 Amyotrophic lateral sclerosis ANXA8 655.4354786 578.4701187 732.4008385 1.266099691 0.340391005 0.188759448 1 8.230308466 10.24601987 653145 annexin A8 "GO:0005509,GO:0005515,GO:0005544,GO:0005546,GO:0005547,GO:0005737,GO:0005829,GO:0005886,GO:0007032,GO:0007596,GO:0016197,GO:0031902,GO:0043325,GO:0051015,GO:0062023,GO:1900004,GO:1900138" "calcium ion binding|protein binding|calcium-dependent phospholipid binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|cytosol|plasma membrane|endosome organization|blood coagulation|endosomal transport|late endosome membrane|phosphatidylinositol-3,4-bisphosphate binding|actin filament binding|collagen-containing extracellular matrix|negative regulation of serine-type endopeptidase activity|negative regulation of phospholipase A2 activity" ANXA8L1 170.742962 155.0216685 186.4642555 1.202827045 0.266429212 0.496385157 1 4.091603131 4.839136418 728113 annexin A8 like 1 "GO:0005509,GO:0005544,GO:0005737,GO:0007032,GO:0016197,GO:1900004,GO:1900138" calcium ion binding|calcium-dependent phospholipid binding|cytoplasm|endosome organization|endosomal transport|negative regulation of serine-type endopeptidase activity|negative regulation of phospholipase A2 activity ANXA9 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.035661514 0.097180679 8416 annexin A9 "GO:0001786,GO:0002020,GO:0005262,GO:0005509,GO:0005515,GO:0005543,GO:0005544,GO:0005546,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007271,GO:0009986,GO:0015464,GO:0019834,GO:0031982,GO:0043086,GO:0045202,GO:0046790,GO:0070588,GO:0098609" "phosphatidylserine binding|protease binding|calcium channel activity|calcium ion binding|protein binding|phospholipid binding|calcium-dependent phospholipid binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular space|nucleus|cytoplasm|cytosol|plasma membrane|synaptic transmission, cholinergic|cell surface|acetylcholine receptor activity|phospholipase A2 inhibitor activity|vesicle|negative regulation of catalytic activity|synapse|virion binding|calcium ion transmembrane transport|cell-cell adhesion" AOC2 40.38805744 50.98028025 29.79583464 0.584458039 -0.774828644 0.234651778 1 1.04804463 0.602288114 314 amine oxidase copper containing 2 "GO:0005507,GO:0005515,GO:0005737,GO:0005886,GO:0006584,GO:0006805,GO:0007601,GO:0008131,GO:0009055,GO:0009308,GO:0022900,GO:0048038,GO:0052593,GO:0052594,GO:0052595,GO:0052596" copper ion binding|protein binding|cytoplasm|plasma membrane|catecholamine metabolic process|xenobiotic metabolic process|visual perception|primary amine oxidase activity|electron transfer activity|amine metabolic process|electron transport chain|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|aliphatic-amine oxidase activity|phenethylamine:oxygen oxidoreductase (deaminating) activity "hsa00260,hsa00350,hsa00360,hsa00410" "Glycine, serine and threonine metabolism|Tyrosine metabolism|Phenylalanine metabolism|beta-Alanine metabolism" AOC3 17.13223052 20.80827765 13.45618338 0.64667454 -0.628888283 0.513000638 1 0.219119877 0.1393281 8639 amine oxidase copper containing 3 "GO:0005507,GO:0005509,GO:0005515,GO:0005737,GO:0005769,GO:0005783,GO:0005794,GO:0005886,GO:0005902,GO:0006805,GO:0006954,GO:0007155,GO:0008131,GO:0009308,GO:0009986,GO:0016021,GO:0042802,GO:0046677,GO:0046982,GO:0048038,GO:0052593,GO:0052594,GO:0052595,GO:0052596,GO:0055114,GO:1902283" copper ion binding|calcium ion binding|protein binding|cytoplasm|early endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|microvillus|xenobiotic metabolic process|inflammatory response|cell adhesion|primary amine oxidase activity|amine metabolic process|cell surface|integral component of membrane|identical protein binding|response to antibiotic|protein heterodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|aliphatic-amine oxidase activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|oxidation-reduction process|negative regulation of primary amine oxidase activity "hsa00260,hsa00350,hsa00360,hsa00410" "Glycine, serine and threonine metabolism|Tyrosine metabolism|Phenylalanine metabolism|beta-Alanine metabolism" AOPEP 134.0309517 124.8496659 143.2122374 1.147077458 0.197962815 0.650633684 1 0.400950608 0.452225243 84909 aminopeptidase O (putative) "GO:0002003,GO:0005730,GO:0005829,GO:0008270,GO:0070006" angiotensin maturation|nucleolus|cytosol|zinc ion binding|metalloaminopeptidase activity AOX1 2783.253901 2617.681329 2948.826473 1.12650323 0.171851451 0.46787971 1 27.4353577 30.3888487 316 aldehyde oxidase 1 "GO:0004031,GO:0004854,GO:0005506,GO:0005829,GO:0009055,GO:0009115,GO:0017144,GO:0022900,GO:0042802,GO:0042803,GO:0042816,GO:0043546,GO:0050660,GO:0051287,GO:0051537,GO:0055114,GO:0070062,GO:0071949,GO:0102797,GO:0102798" "aldehyde oxidase activity|xanthine dehydrogenase activity|iron ion binding|cytosol|electron transfer activity|xanthine catabolic process|drug metabolic process|electron transport chain|identical protein binding|protein homodimerization activity|vitamin B6 metabolic process|molybdopterin cofactor binding|flavin adenine dinucleotide binding|NAD binding|2 iron, 2 sulfur cluster binding|oxidation-reduction process|extracellular exosome|FAD binding|geranial:oxygen oxidoreductase activity|heptaldehyde:oxygen oxidoreductase activity" "hsa00280,hsa00350,hsa00380,hsa00750,hsa00760,hsa00830,hsa00982,hsa04630" "Valine, leucine and isoleucine degradation|Tyrosine metabolism|Tryptophan metabolism|Vitamin B6 metabolism|Nicotinate and nicotinamide metabolism|Retinol metabolism|Drug metabolism - cytochrome P450|JAK-STAT signaling pathway" AP1AR 739.0397268 817.7653118 660.3141418 0.807461667 -0.308534323 0.225005861 1 13.96117457 11.084473 55435 adaptor related protein complex 1 associated regulatory protein "GO:0001920,GO:0005768,GO:0005769,GO:0005770,GO:0005794,GO:0005829,GO:0015031,GO:0019894,GO:0030133,GO:0034315,GO:0034613,GO:0035650,GO:0048203,GO:1900025,GO:2000146" "negative regulation of receptor recycling|endosome|early endosome|late endosome|Golgi apparatus|cytosol|protein transport|kinesin binding|transport vesicle|regulation of Arp2/3 complex-mediated actin nucleation|cellular protein localization|AP-1 adaptor complex binding|vesicle targeting, trans-Golgi to endosome|negative regulation of substrate adhesion-dependent cell spreading|negative regulation of cell motility" AP1B1 2393.140282 2330.527097 2455.753468 1.053733068 0.075509449 0.750643274 1 29.86217235 30.94020489 162 adaptor related protein complex 1 subunit beta 1 "GO:0000139,GO:0001822,GO:0005515,GO:0005765,GO:0005794,GO:0005829,GO:0006886,GO:0007368,GO:0007507,GO:0016192,GO:0019886,GO:0019901,GO:0030131,GO:0030276,GO:0030659,GO:0030665,GO:0032588,GO:0043231,GO:0050690" Golgi membrane|kidney development|protein binding|lysosomal membrane|Golgi apparatus|cytosol|intracellular protein transport|determination of left/right symmetry|heart development|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|clathrin adaptor complex|clathrin binding|cytoplasmic vesicle membrane|clathrin-coated vesicle membrane|trans-Golgi network membrane|intracellular membrane-bounded organelle|regulation of defense response to virus by virus "hsa04142,hsa05170" Lysosome|Human immunodeficiency virus 1 infection AP1G1 2278.816215 2495.952904 2061.679526 0.826008985 -0.27577062 0.243376399 1 20.14890624 16.36467656 164 adaptor related protein complex 1 subunit gamma 1 "GO:0000139,GO:0005515,GO:0005737,GO:0005765,GO:0005794,GO:0005829,GO:0006886,GO:0006896,GO:0006898,GO:0016020,GO:0019886,GO:0019894,GO:0030121,GO:0030136,GO:0030659,GO:0030665,GO:0030742,GO:0031267,GO:0032438,GO:0032588,GO:0035615,GO:0035646,GO:0043231,GO:0043323,GO:0045954,GO:0050690,GO:0055037,GO:0090160,GO:0140312" Golgi membrane|protein binding|cytoplasm|lysosomal membrane|Golgi apparatus|cytosol|intracellular protein transport|Golgi to vacuole transport|receptor-mediated endocytosis|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|kinesin binding|AP-1 adaptor complex|clathrin-coated vesicle|cytoplasmic vesicle membrane|clathrin-coated vesicle membrane|GTP-dependent protein binding|small GTPase binding|melanosome organization|trans-Golgi network membrane|clathrin adaptor activity|endosome to melanosome transport|intracellular membrane-bounded organelle|positive regulation of natural killer cell degranulation|positive regulation of natural killer cell mediated cytotoxicity|regulation of defense response to virus by virus|recycling endosome|Golgi to lysosome transport|cargo adaptor activity "hsa04142,hsa05170" Lysosome|Human immunodeficiency virus 1 infection AP1G2 1113.165324 1126.768235 1099.562414 0.975854998 -0.035261301 0.888522484 1 16.92949037 16.24427578 8906 adaptor related protein complex 1 subunit gamma 2 "GO:0000139,GO:0005515,GO:0005794,GO:0005798,GO:0006886,GO:0006896,GO:0006898,GO:0010008,GO:0016020,GO:0016032,GO:0016192,GO:0030121,GO:0030133,GO:0035615,GO:0140312" Golgi membrane|protein binding|Golgi apparatus|Golgi-associated vesicle|intracellular protein transport|Golgi to vacuole transport|receptor-mediated endocytosis|endosome membrane|membrane|viral process|vesicle-mediated transport|AP-1 adaptor complex|transport vesicle|clathrin adaptor activity|cargo adaptor activity "hsa04142,hsa05170" Lysosome|Human immunodeficiency virus 1 infection AP1M1 2362.375074 2052.73659 2672.013558 1.301683601 0.380378817 0.107680399 1 8.495601323 10.87353448 8907 adaptor related protein complex 1 subunit mu 1 "GO:0000139,GO:0005515,GO:0005765,GO:0005829,GO:0005886,GO:0006886,GO:0016020,GO:0016192,GO:0019886,GO:0030131,GO:0030136,GO:0030659,GO:0030665,GO:0031410,GO:0032438,GO:0032588,GO:0035579,GO:0035615,GO:0035646,GO:0043231,GO:0043312,GO:0050690,GO:0070062" Golgi membrane|protein binding|lysosomal membrane|cytosol|plasma membrane|intracellular protein transport|membrane|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|clathrin adaptor complex|clathrin-coated vesicle|cytoplasmic vesicle membrane|clathrin-coated vesicle membrane|cytoplasmic vesicle|melanosome organization|trans-Golgi network membrane|specific granule membrane|clathrin adaptor activity|endosome to melanosome transport|intracellular membrane-bounded organelle|neutrophil degranulation|regulation of defense response to virus by virus|extracellular exosome "hsa04142,hsa05170" Lysosome|Human immunodeficiency virus 1 infection AP1M2 221.916971 173.7491184 270.0848236 1.554452915 0.636406918 0.068803819 1 4.664321485 7.129141365 10053 adaptor related protein complex 1 subunit mu 2 "GO:0000139,GO:0005515,GO:0005765,GO:0005829,GO:0006605,GO:0006903,GO:0016192,GO:0019886,GO:0030131,GO:0030136,GO:0030659,GO:0030665,GO:0031410,GO:0032588,GO:0035615,GO:0043231,GO:0050690" Golgi membrane|protein binding|lysosomal membrane|cytosol|protein targeting|vesicle targeting|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|clathrin adaptor complex|clathrin-coated vesicle|cytoplasmic vesicle membrane|clathrin-coated vesicle membrane|cytoplasmic vesicle|trans-Golgi network membrane|clathrin adaptor activity|intracellular membrane-bounded organelle|regulation of defense response to virus by virus "hsa04142,hsa05170" Lysosome|Human immunodeficiency virus 1 infection AP1S1 1577.77356 1401.4375 1754.10962 1.251650266 0.323831503 0.173899187 1 61.00501112 75.07920845 1174 adaptor related protein complex 1 subunit sigma 1 "GO:0000139,GO:0005765,GO:0005794,GO:0005829,GO:0005905,GO:0006886,GO:0006898,GO:0009615,GO:0016020,GO:0016192,GO:0019886,GO:0030121,GO:0030659,GO:0032588,GO:0043231,GO:0050690" Golgi membrane|lysosomal membrane|Golgi apparatus|cytosol|clathrin-coated pit|intracellular protein transport|receptor-mediated endocytosis|response to virus|membrane|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|AP-1 adaptor complex|cytoplasmic vesicle membrane|trans-Golgi network membrane|intracellular membrane-bounded organelle|regulation of defense response to virus by virus "hsa04142,hsa05170" Lysosome|Human immunodeficiency virus 1 infection AP1S2 1605.745233 1555.418755 1656.071712 1.064711164 0.090462107 0.705560054 1 14.83908477 15.53495867 8905 adaptor related protein complex 1 subunit sigma 2 "GO:0000139,GO:0005515,GO:0005765,GO:0005794,GO:0005829,GO:0005905,GO:0006886,GO:0016192,GO:0019886,GO:0030119,GO:0030659,GO:0032588,GO:0043231,GO:0050690" Golgi membrane|protein binding|lysosomal membrane|Golgi apparatus|cytosol|clathrin-coated pit|intracellular protein transport|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|AP-type membrane coat adaptor complex|cytoplasmic vesicle membrane|trans-Golgi network membrane|intracellular membrane-bounded organelle|regulation of defense response to virus by virus "hsa04142,hsa05170" Lysosome|Human immunodeficiency virus 1 infection AP1S3 294.5528284 301.720026 287.3856308 0.952491072 -0.070222526 0.83418574 1 4.039699761 3.783390601 130340 adaptor related protein complex 1 subunit sigma 3 "GO:0000139,GO:0005515,GO:0005765,GO:0005829,GO:0005905,GO:0006605,GO:0016192,GO:0019886,GO:0030117,GO:0030659,GO:0032588,GO:0043231,GO:0050690" Golgi membrane|protein binding|lysosomal membrane|cytosol|clathrin-coated pit|protein targeting|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|membrane coat|cytoplasmic vesicle membrane|trans-Golgi network membrane|intracellular membrane-bounded organelle|regulation of defense response to virus by virus "hsa04142,hsa05170" Lysosome|Human immunodeficiency virus 1 infection AP2A1 2487.288907 2341.97165 2632.606163 1.12409822 0.168768099 0.475690184 1 28.99251278 32.04507527 160 adaptor related protein complex 2 subunit alpha 1 "GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0006895,GO:0006897,GO:0006898,GO:0008022,GO:0010976,GO:0016020,GO:0016323,GO:0016324,GO:0019886,GO:0019901,GO:0030122,GO:0030130,GO:0030666,GO:0030669,GO:0032433,GO:0032802,GO:0034383,GO:0035615,GO:0036020,GO:0044877,GO:0045334,GO:0048013,GO:0048260,GO:0050690,GO:0050750,GO:0060071,GO:0061024,GO:0072583,GO:0140312,GO:1900126" "protein binding|cytosol|plasma membrane|intracellular protein transport|Golgi to endosome transport|endocytosis|receptor-mediated endocytosis|protein C-terminus binding|positive regulation of neuron projection development|membrane|basolateral plasma membrane|apical plasma membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|filopodium tip|low-density lipoprotein particle receptor catabolic process|low-density lipoprotein particle clearance|clathrin adaptor activity|endolysosome membrane|protein-containing complex binding|clathrin-coated endocytic vesicle|ephrin receptor signaling pathway|positive regulation of receptor-mediated endocytosis|regulation of defense response to virus by virus|low-density lipoprotein particle receptor binding|Wnt signaling pathway, planar cell polarity pathway|membrane organization|clathrin-dependent endocytosis|cargo adaptor activity|negative regulation of hyaluronan biosynthetic process" "hsa04144,hsa04721,hsa04961,hsa05016" Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease AP2A2 1659.633519 1695.874629 1623.39241 0.957259683 -0.063017746 0.792930898 1 19.04180771 17.92293468 161 adaptor related protein complex 2 subunit alpha 2 "GO:0003674,GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0006898,GO:0008289,GO:0019886,GO:0019901,GO:0030122,GO:0030666,GO:0030667,GO:0030669,GO:0031410,GO:0032802,GO:0034383,GO:0035615,GO:0036020,GO:0043312,GO:0045334,GO:0048013,GO:0050690,GO:0060071,GO:0061024,GO:0072583,GO:0097718,GO:0101003,GO:0140312" "molecular_function|protein binding|cytosol|plasma membrane|intracellular protein transport|receptor-mediated endocytosis|lipid binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|AP-2 adaptor complex|endocytic vesicle membrane|secretory granule membrane|clathrin-coated endocytic vesicle membrane|cytoplasmic vesicle|low-density lipoprotein particle receptor catabolic process|low-density lipoprotein particle clearance|clathrin adaptor activity|endolysosome membrane|neutrophil degranulation|clathrin-coated endocytic vesicle|ephrin receptor signaling pathway|regulation of defense response to virus by virus|Wnt signaling pathway, planar cell polarity pathway|membrane organization|clathrin-dependent endocytosis|disordered domain specific binding|ficolin-1-rich granule membrane|cargo adaptor activity" "hsa04144,hsa04721,hsa04961,hsa05016" Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease AP2B1 10952.61396 10730.82879 11174.39914 1.041336076 0.058435753 0.817924845 1 87.40607599 89.49601884 163 adaptor related protein complex 2 subunit beta 1 "GO:0001822,GO:0003281,GO:0005048,GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0016020,GO:0016192,GO:0019886,GO:0030122,GO:0030131,GO:0030276,GO:0030666,GO:0030669,GO:0032802,GO:0034383,GO:0035615,GO:0035904,GO:0036020,GO:0044877,GO:0045334,GO:0045807,GO:0048013,GO:0048268,GO:0050690,GO:0060071,GO:0060976,GO:0061024,GO:0072583,GO:0098794,GO:0098884,GO:0098978,GO:1901215,GO:1905477" "kidney development|ventricular septum development|signal sequence binding|protein binding|cytosol|plasma membrane|intracellular protein transport|membrane|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|AP-2 adaptor complex|clathrin adaptor complex|clathrin binding|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|low-density lipoprotein particle receptor catabolic process|low-density lipoprotein particle clearance|clathrin adaptor activity|aorta development|endolysosome membrane|protein-containing complex binding|clathrin-coated endocytic vesicle|positive regulation of endocytosis|ephrin receptor signaling pathway|clathrin coat assembly|regulation of defense response to virus by virus|Wnt signaling pathway, planar cell polarity pathway|coronary vasculature development|membrane organization|clathrin-dependent endocytosis|postsynapse|postsynaptic neurotransmitter receptor internalization|glutamatergic synapse|negative regulation of neuron death|positive regulation of protein localization to membrane" "hsa04144,hsa04721,hsa04961,hsa05016" Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease AP2M1 7528.733184 7557.566444 7499.899925 0.992369697 -0.011050413 0.964688327 1 201.0635249 196.1904959 1173 adaptor related protein complex 2 subunit mu 1 "GO:0005048,GO:0005515,GO:0005765,GO:0005829,GO:0005886,GO:0005905,GO:0006886,GO:0006897,GO:0006900,GO:0008289,GO:0016192,GO:0019886,GO:0030122,GO:0030666,GO:0030669,GO:0031410,GO:0031623,GO:0032802,GO:0034383,GO:0034622,GO:0035615,GO:0036020,GO:0043231,GO:0044325,GO:0045334,GO:0048013,GO:0050690,GO:0050750,GO:0060071,GO:0061024,GO:0070062,GO:0072583,GO:0097494,GO:1903077" "signal sequence binding|protein binding|lysosomal membrane|cytosol|plasma membrane|clathrin-coated pit|intracellular protein transport|endocytosis|vesicle budding from membrane|lipid binding|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|AP-2 adaptor complex|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|cytoplasmic vesicle|receptor internalization|low-density lipoprotein particle receptor catabolic process|low-density lipoprotein particle clearance|cellular protein-containing complex assembly|clathrin adaptor activity|endolysosome membrane|intracellular membrane-bounded organelle|ion channel binding|clathrin-coated endocytic vesicle|ephrin receptor signaling pathway|regulation of defense response to virus by virus|low-density lipoprotein particle receptor binding|Wnt signaling pathway, planar cell polarity pathway|membrane organization|extracellular exosome|clathrin-dependent endocytosis|regulation of vesicle size|negative regulation of protein localization to plasma membrane" "hsa04144,hsa04721,hsa04961,hsa05016" Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease AP2S1 1557.316298 1482.589783 1632.042813 1.100805383 0.13855943 0.562006116 1 74.64442625 80.7939995 1175 adaptor related protein complex 2 subunit sigma 1 "GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0016192,GO:0019886,GO:0030100,GO:0030122,GO:0030666,GO:0030669,GO:0032802,GO:0034383,GO:0035615,GO:0036020,GO:0043231,GO:0045334,GO:0048013,GO:0048268,GO:0050690,GO:0060071,GO:0061024,GO:0072583" "protein binding|cytosol|plasma membrane|intracellular protein transport|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|regulation of endocytosis|AP-2 adaptor complex|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|low-density lipoprotein particle receptor catabolic process|low-density lipoprotein particle clearance|clathrin adaptor activity|endolysosome membrane|intracellular membrane-bounded organelle|clathrin-coated endocytic vesicle|ephrin receptor signaling pathway|clathrin coat assembly|regulation of defense response to virus by virus|Wnt signaling pathway, planar cell polarity pathway|membrane organization|clathrin-dependent endocytosis" "hsa04144,hsa04721,hsa04961,hsa05016" Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease AP3B1 2486.902678 2306.597578 2667.207778 1.156338584 0.209563891 0.375561407 1 15.1469021 17.22185841 8546 adaptor related protein complex 3 subunit beta 1 "GO:0000902,GO:0002224,GO:0002244,GO:0003016,GO:0005515,GO:0005739,GO:0005765,GO:0005794,GO:0006464,GO:0006622,GO:0006882,GO:0006886,GO:0006954,GO:0007040,GO:0007283,GO:0007338,GO:0007596,GO:0008089,GO:0016020,GO:0016182,GO:0016192,GO:0019903,GO:0030123,GO:0030131,GO:0030665,GO:0030742,GO:0030851,GO:0032438,GO:0034394,GO:0042789,GO:0045202,GO:0045944,GO:0048007,GO:0048490,GO:0048872,GO:0050790,GO:0051138,GO:0060155,GO:0060425,GO:0090152,GO:0098773,GO:1904115" "cell morphogenesis|toll-like receptor signaling pathway|hematopoietic progenitor cell differentiation|respiratory system process|protein binding|mitochondrion|lysosomal membrane|Golgi apparatus|cellular protein modification process|protein targeting to lysosome|cellular zinc ion homeostasis|intracellular protein transport|inflammatory response|lysosome organization|spermatogenesis|single fertilization|blood coagulation|anterograde axonal transport|membrane|synaptic vesicle budding from endosome|vesicle-mediated transport|protein phosphatase binding|AP-3 adaptor complex|clathrin adaptor complex|clathrin-coated vesicle membrane|GTP-dependent protein binding|granulocyte differentiation|melanosome organization|protein localization to cell surface|mRNA transcription by RNA polymerase II|synapse|positive regulation of transcription by RNA polymerase II|antigen processing and presentation, exogenous lipid antigen via MHC class Ib|anterograde synaptic vesicle transport|homeostasis of number of cells|regulation of catalytic activity|positive regulation of NK T cell differentiation|platelet dense granule organization|lung morphogenesis|establishment of protein localization to mitochondrial membrane involved in mitochondrial fission|skin epidermis development|axon cytoplasm" hsa04142 Lysosome AP3D1 2832.3553 2910.03763 2754.67297 0.946610773 -0.079156754 0.738928205 1 30.57754674 28.46067919 8943 adaptor related protein complex 3 subunit delta 1 "GO:0000139,GO:0005515,GO:0005765,GO:0005794,GO:0006623,GO:0006886,GO:0006896,GO:0008089,GO:0010008,GO:0016020,GO:0016182,GO:0030123,GO:0032438,GO:0035646,GO:0043195,GO:0045944,GO:0048007,GO:0048490,GO:0048499,GO:0051138,GO:0061088,GO:0072657,GO:0098794,GO:0098830,GO:0098943,GO:0098978,GO:1904115" "Golgi membrane|protein binding|lysosomal membrane|Golgi apparatus|protein targeting to vacuole|intracellular protein transport|Golgi to vacuole transport|anterograde axonal transport|endosome membrane|membrane|synaptic vesicle budding from endosome|AP-3 adaptor complex|melanosome organization|endosome to melanosome transport|terminal bouton|positive regulation of transcription by RNA polymerase II|antigen processing and presentation, exogenous lipid antigen via MHC class Ib|anterograde synaptic vesicle transport|synaptic vesicle membrane organization|positive regulation of NK T cell differentiation|regulation of sequestering of zinc ion|protein localization to membrane|postsynapse|presynaptic endosome|neurotransmitter receptor transport, postsynaptic endosome to lysosome|glutamatergic synapse|axon cytoplasm" hsa04142 Lysosome AP3M1 3210.757024 3142.049926 3279.464122 1.043733932 0.061753987 0.795416885 1 30.85288495 31.66334265 26985 adaptor related protein complex 3 subunit mu 1 "GO:0005515,GO:0005764,GO:0005765,GO:0005794,GO:0006622,GO:0006897,GO:0008089,GO:0016032,GO:0016192,GO:0030131,GO:0030659,GO:0031267,GO:0031410,GO:0043231,GO:0048490,GO:1904115" protein binding|lysosome|lysosomal membrane|Golgi apparatus|protein targeting to lysosome|endocytosis|anterograde axonal transport|viral process|vesicle-mediated transport|clathrin adaptor complex|cytoplasmic vesicle membrane|small GTPase binding|cytoplasmic vesicle|intracellular membrane-bounded organelle|anterograde synaptic vesicle transport|axon cytoplasm hsa04142 Lysosome AP3M2 772.4273202 848.9777282 695.8769121 0.819664508 -0.286894565 0.256555335 1 10.00626789 8.064536923 10947 adaptor related protein complex 3 subunit mu 2 "GO:0005794,GO:0006886,GO:0006897,GO:0008089,GO:0016192,GO:0030119,GO:0030131,GO:0030659,GO:0031410,GO:0043231,GO:0048490,GO:1904115" Golgi apparatus|intracellular protein transport|endocytosis|anterograde axonal transport|vesicle-mediated transport|AP-type membrane coat adaptor complex|clathrin adaptor complex|cytoplasmic vesicle membrane|cytoplasmic vesicle|intracellular membrane-bounded organelle|anterograde synaptic vesicle transport|axon cytoplasm hsa04142 Lysosome AP3S1 1604.319819 1316.123562 1892.516077 1.437947114 0.524010616 0.027822673 0.877967194 8.591938293 12.14801282 1176 adaptor related protein complex 3 subunit sigma 1 "GO:0005515,GO:0005794,GO:0006886,GO:0008089,GO:0008286,GO:0016192,GO:0030119,GO:0030123,GO:0030133,GO:0030659,GO:0043231,GO:0048490,GO:1904115" protein binding|Golgi apparatus|intracellular protein transport|anterograde axonal transport|insulin receptor signaling pathway|vesicle-mediated transport|AP-type membrane coat adaptor complex|AP-3 adaptor complex|transport vesicle|cytoplasmic vesicle membrane|intracellular membrane-bounded organelle|anterograde synaptic vesicle transport|axon cytoplasm hsa04142 Lysosome AP3S2 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.020034269 0.02729755 10239 adaptor related protein complex 3 subunit sigma 2 "GO:0005794,GO:0006886,GO:0008089,GO:0016192,GO:0030123,GO:0030659,GO:0043231,GO:0048490,GO:1904115" Golgi apparatus|intracellular protein transport|anterograde axonal transport|vesicle-mediated transport|AP-3 adaptor complex|cytoplasmic vesicle membrane|intracellular membrane-bounded organelle|anterograde synaptic vesicle transport|axon cytoplasm hsa04142 Lysosome AP4B1 612.6986371 591.9954992 633.401775 1.069943565 0.097534703 0.714179519 1 8.674824753 9.126258371 10717 adaptor related protein complex 4 subunit beta 1 "GO:0005515,GO:0005802,GO:0005829,GO:0006605,GO:0008104,GO:0016192,GO:0019898,GO:0030124,GO:0030131,GO:0030276,GO:0031904,GO:0032588" protein binding|trans-Golgi network|cytosol|protein targeting|protein localization|vesicle-mediated transport|extrinsic component of membrane|AP-4 adaptor complex|clathrin adaptor complex|clathrin binding|endosome lumen|trans-Golgi network membrane hsa04142 Lysosome AP4E1 343.7844038 370.3873422 317.1814655 0.856350715 -0.223726327 0.461832464 1 4.03241365 3.395376352 23431 adaptor related protein complex 4 subunit epsilon 1 "GO:0005515,GO:0006605,GO:0006898,GO:0008104,GO:0030124,GO:0031904,GO:0032588,GO:0140312" protein binding|protein targeting|receptor-mediated endocytosis|protein localization|AP-4 adaptor complex|endosome lumen|trans-Golgi network membrane|cargo adaptor activity hsa04142 Lysosome AP4M1 413.2845427 428.6505196 397.9185658 0.928305339 -0.10732868 0.714213416 1 10.96658217 10.00998263 9179 adaptor related protein complex 4 subunit mu 1 "GO:0005515,GO:0005769,GO:0005802,GO:0005829,GO:0006605,GO:0006622,GO:0006886,GO:0006895,GO:0008104,GO:0016192,GO:0019904,GO:0030124,GO:0030131,GO:0031410,GO:0031904,GO:0032588,GO:0043231,GO:0070062,GO:0090160,GO:1903361" protein binding|early endosome|trans-Golgi network|cytosol|protein targeting|protein targeting to lysosome|intracellular protein transport|Golgi to endosome transport|protein localization|vesicle-mediated transport|protein domain specific binding|AP-4 adaptor complex|clathrin adaptor complex|cytoplasmic vesicle|endosome lumen|trans-Golgi network membrane|intracellular membrane-bounded organelle|extracellular exosome|Golgi to lysosome transport|protein localization to basolateral plasma membrane hsa04142 Lysosome AP4S1 93.83600864 91.55642167 96.1155956 1.049796332 0.070109461 0.906344462 1 0.689946054 0.712182609 11154 adaptor related protein complex 4 subunit sigma 1 "GO:0006605,GO:0008104,GO:0016192,GO:0030124,GO:0031904,GO:0032588,GO:0043231" protein targeting|protein localization|vesicle-mediated transport|AP-4 adaptor complex|endosome lumen|trans-Golgi network membrane|intracellular membrane-bounded organelle hsa04142 Lysosome AP5B1 704.3739457 778.2295842 630.5183071 0.810195757 -0.303657565 0.235685 1 5.950241058 4.740189494 91056 adaptor related protein complex 5 subunit beta 1 "GO:0005515,GO:0005765,GO:0015031,GO:0016197,GO:0030119" protein binding|lysosomal membrane|protein transport|endosomal transport|AP-type membrane coat adaptor complex AP5M1 581.0647789 581.5913604 580.5381974 0.99818917 -0.002614843 0.999599829 1 2.636410599 2.587599635 55745 adaptor related protein complex 5 subunit mu 1 "GO:0005764,GO:0005765,GO:0005770,GO:0005829,GO:0015031,GO:0016020,GO:0016197,GO:0030119,GO:0031902" lysosome|lysosomal membrane|late endosome|cytosol|protein transport|membrane|endosomal transport|AP-type membrane coat adaptor complex|late endosome membrane AP5S1 215.0052114 232.0122958 197.9981269 0.853394973 -0.228714483 0.523377405 1 2.329208015 1.954472368 55317 adaptor related protein complex 5 subunit sigma 1 "GO:0000724,GO:0005515,GO:0005654,GO:0005764,GO:0005765,GO:0005770,GO:0005829,GO:0015031,GO:0016197,GO:0030119,GO:0031902" double-strand break repair via homologous recombination|protein binding|nucleoplasm|lysosome|lysosomal membrane|late endosome|cytosol|protein transport|endosomal transport|AP-type membrane coat adaptor complex|late endosome membrane AP5Z1 607.2135202 687.7135764 526.7134639 0.765890746 -0.384789488 0.14234099 1 6.638091809 4.998978342 9907 adaptor related protein complex 5 subunit zeta 1 "GO:0000724,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0015031,GO:0016197,GO:0016607,GO:0030119,GO:0044599" double-strand break repair via homologous recombination|protein binding|nucleus|nucleoplasm|cytoplasm|protein transport|endosomal transport|nuclear speck|AP-type membrane coat adaptor complex|AP-5 adaptor complex APAF1 974.0612509 969.6657386 978.4567632 1.009066036 0.013020592 0.962454118 1 6.889798735 6.835925212 317 apoptotic peptidase activating factor 1 "GO:0000166,GO:0001666,GO:0001822,GO:0001843,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005829,GO:0006915,GO:0006919,GO:0007399,GO:0007568,GO:0007584,GO:0008635,GO:0008656,GO:0010659,GO:0030154,GO:0030900,GO:0031072,GO:0032991,GO:0034774,GO:0042802,GO:0042981,GO:0043065,GO:0043293,GO:0043312,GO:0043531,GO:0051402,GO:0070059,GO:0070062,GO:0070317,GO:0071560,GO:0072432,GO:0097193,GO:1902510,GO:1904813,GO:2001235" nucleotide binding|response to hypoxia|kidney development|neural tube closure|protein binding|ATP binding|extracellular region|nucleus|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|nervous system development|aging|response to nutrient|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|cysteine-type endopeptidase activator activity involved in apoptotic process|cardiac muscle cell apoptotic process|cell differentiation|forebrain development|heat shock protein binding|protein-containing complex|secretory granule lumen|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|apoptosome|neutrophil degranulation|ADP binding|neuron apoptotic process|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|extracellular exosome|negative regulation of G0 to G1 transition|cellular response to transforming growth factor beta stimulus|response to G1 DNA damage checkpoint signaling|intrinsic apoptotic signaling pathway|regulation of apoptotic DNA fragmentation|ficolin-1-rich granule lumen|positive regulation of apoptotic signaling pathway "hsa01524,hsa04115,hsa04210,hsa04215,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05134,hsa05152,hsa05160,hsa05161,hsa05162,hsa05164,hsa05168,hsa05169,hsa05200,hsa05222" Platinum drug resistance|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Legionellosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Small cell lung cancer APBA1 252.5450139 195.5978099 309.4922178 1.582288769 0.662012917 0.047502982 1 1.447807992 2.252516047 320 amyloid beta precursor protein binding family A member 1 "GO:0001540,GO:0001701,GO:0005515,GO:0005634,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0006886,GO:0007155,GO:0007268,GO:0007269,GO:0007399,GO:0007626,GO:0008021,GO:0008088,GO:0010468,GO:0014047,GO:0014051,GO:0035264,GO:0043197,GO:0048471,GO:0048787,GO:0065003,GO:0098685,GO:0098978,GO:2000300" amyloid-beta binding|in utero embryonic development|protein binding|nucleus|cytoplasm|Golgi apparatus|cytosol|plasma membrane|intracellular protein transport|cell adhesion|chemical synaptic transmission|neurotransmitter secretion|nervous system development|locomotory behavior|synaptic vesicle|axo-dendritic transport|regulation of gene expression|glutamate secretion|gamma-aminobutyric acid secretion|multicellular organism growth|dendritic spine|perinuclear region of cytoplasm|presynaptic active zone membrane|protein-containing complex assembly|Schaffer collateral - CA1 synapse|glutamatergic synapse|regulation of synaptic vesicle exocytosis APBA2 201.6830061 197.6786377 205.6873746 1.040513922 0.057296268 0.888055938 1 1.649428639 1.687534285 321 amyloid beta precursor protein binding family A member 2 "GO:0001540,GO:0005515,GO:0005737,GO:0005886,GO:0007268,GO:0007399,GO:0008021,GO:0015031,GO:0042802,GO:0043197" amyloid-beta binding|protein binding|cytoplasm|plasma membrane|chemical synaptic transmission|nervous system development|synaptic vesicle|protein transport|identical protein binding|dendritic spine APBA3 203.1989676 212.2444321 194.1535031 0.914763705 -0.128528969 0.732277418 1 5.217455205 4.692873338 9546 amyloid beta precursor protein binding family A member 3 "GO:0001540,GO:0001701,GO:0004857,GO:0005515,GO:0005737,GO:0005886,GO:0007268,GO:0010468,GO:0015031,GO:0019899,GO:0043086,GO:0043197,GO:0048471" amyloid-beta binding|in utero embryonic development|enzyme inhibitor activity|protein binding|cytoplasm|plasma membrane|chemical synaptic transmission|regulation of gene expression|protein transport|enzyme binding|negative regulation of catalytic activity|dendritic spine|perinuclear region of cytoplasm APBB1 1371.358387 1319.244803 1423.471971 1.079005176 0.109701785 0.649134229 1 19.6663884 20.86504466 322 amyloid beta precursor protein binding family B member 1 "GO:0000122,GO:0001540,GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005886,GO:0006355,GO:0006915,GO:0006974,GO:0007050,GO:0007165,GO:0007409,GO:0008134,GO:0016607,GO:0030027,GO:0030308,GO:0030426,GO:0031625,GO:0042393,GO:0043065,GO:0043967,GO:0045202,GO:0045893,GO:0045944,GO:0050714,GO:0050750,GO:0070064" "negative regulation of transcription by RNA polymerase II|amyloid-beta binding|chromatin binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|plasma membrane|regulation of transcription, DNA-templated|apoptotic process|cellular response to DNA damage stimulus|cell cycle arrest|signal transduction|axonogenesis|transcription factor binding|nuclear speck|lamellipodium|negative regulation of cell growth|growth cone|ubiquitin protein ligase binding|histone binding|positive regulation of apoptotic process|histone H4 acetylation|synapse|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of protein secretion|low-density lipoprotein particle receptor binding|proline-rich region binding" hsa05010 Alzheimer disease APBB2 3861.733937 3653.933556 4069.534318 1.113740646 0.155413315 0.513885116 1 17.37226888 19.02443601 323 amyloid beta precursor protein binding family B member 2 "GO:0001540,GO:0005515,GO:0005634,GO:0005737,GO:0006355,GO:0007050,GO:0008134,GO:0016020,GO:0030027,GO:0030308,GO:0030426,GO:0035556,GO:0045202,GO:0050808" "amyloid-beta binding|protein binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|cell cycle arrest|transcription factor binding|membrane|lamellipodium|negative regulation of cell growth|growth cone|intracellular signal transduction|synapse|synapse organization" APBB3 163.3260867 174.7895323 151.862641 0.86883144 -0.202851785 0.614326888 1 4.33466361 3.703071577 10307 amyloid beta precursor protein binding family B member 3 "GO:0001540,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006355,GO:0008134,GO:0015629,GO:0016020,GO:0050714,GO:0050750" "amyloid-beta binding|protein binding|nucleus|cytoplasm|cytosol|regulation of transcription, DNA-templated|transcription factor binding|actin cytoskeleton|membrane|positive regulation of protein secretion|low-density lipoprotein particle receptor binding" APC 1118.549833 1280.74949 956.3501762 0.746711347 -0.421377441 0.083460477 1 5.976326514 4.387915406 324 APC regulator of WNT signaling pathway "GO:0000281,GO:0000776,GO:0001708,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0005874,GO:0005881,GO:0005886,GO:0005912,GO:0005923,GO:0006974,GO:0007026,GO:0007050,GO:0007094,GO:0007155,GO:0007389,GO:0007399,GO:0008013,GO:0008017,GO:0008285,GO:0008286,GO:0010942,GO:0016055,GO:0016328,GO:0016342,GO:0016477,GO:0016579,GO:0019887,GO:0019901,GO:0030027,GO:0030335,GO:0030877,GO:0031274,GO:0031625,GO:0032587,GO:0032886,GO:0043065,GO:0045295,GO:0045296,GO:0045595,GO:0045732,GO:0045736,GO:0048471,GO:0051010,GO:0051988,GO:0065003,GO:0070830,GO:0070840,GO:0090090,GO:0120162,GO:1904781,GO:1904885,GO:1904886,GO:1990909,GO:2000134" mitotic cytokinesis|kinetochore|cell fate specification|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|centrosome|cytosol|microtubule|cytoplasmic microtubule|plasma membrane|adherens junction|bicellular tight junction|cellular response to DNA damage stimulus|negative regulation of microtubule depolymerization|cell cycle arrest|mitotic spindle assembly checkpoint|cell adhesion|pattern specification process|nervous system development|beta-catenin binding|microtubule binding|negative regulation of cell population proliferation|insulin receptor signaling pathway|positive regulation of cell death|Wnt signaling pathway|lateral plasma membrane|catenin complex|cell migration|protein deubiquitination|protein kinase regulator activity|protein kinase binding|lamellipodium|positive regulation of cell migration|beta-catenin destruction complex|positive regulation of pseudopodium assembly|ubiquitin protein ligase binding|ruffle membrane|regulation of microtubule-based process|positive regulation of apoptotic process|gamma-catenin binding|cadherin binding|regulation of cell differentiation|positive regulation of protein catabolic process|negative regulation of cyclin-dependent protein serine/threonine kinase activity|perinuclear region of cytoplasm|microtubule plus-end binding|regulation of attachment of spindle microtubules to kinetochore|protein-containing complex assembly|bicellular tight junction assembly|dynein complex binding|negative regulation of canonical Wnt signaling pathway|positive regulation of cold-induced thermogenesis|positive regulation of protein localization to centrosome|beta-catenin destruction complex assembly|beta-catenin destruction complex disassembly|Wnt signalosome|negative regulation of G1/S transition of mitotic cell cycle "hsa04310,hsa04390,hsa04550,hsa04810,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05206,hsa05210,hsa05213,hsa05217,hsa05224,hsa05225,hsa05226" Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|MicroRNAs in cancer|Colorectal cancer|Endometrial cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer other APCDD1L 144.216824 190.3957405 98.03790751 0.514916496 -0.957589606 0.020180047 0.810058917 2.503960261 1.267755244 164284 APC down-regulated 1 like "GO:0005515,GO:0005886,GO:0016021,GO:0017147,GO:0030178" protein binding|plasma membrane|integral component of membrane|Wnt-protein binding|negative regulation of Wnt signaling pathway APEH 3026.652842 2850.734038 3202.571645 1.123420004 0.167897398 0.4785698 1 40.6678525 44.92256763 327 acylaminoacyl-peptide hydrolase "GO:0003723,GO:0004252,GO:0005515,GO:0005576,GO:0005829,GO:0006415,GO:0006508,GO:0008242,GO:0031965,GO:0042802,GO:0043312,GO:0050435,GO:0070062,GO:1904813" RNA binding|serine-type endopeptidase activity|protein binding|extracellular region|cytosol|translational termination|proteolysis|omega peptidase activity|nuclear membrane|identical protein binding|neutrophil degranulation|amyloid-beta metabolic process|extracellular exosome|ficolin-1-rich granule lumen APEX1 3767.143749 3744.449564 3789.837934 1.012121507 0.017382498 0.942891408 1 144.076706 143.3829801 328 apurinic/apyrimidinic endodeoxyribonuclease 1 "GO:0000723,GO:0000781,GO:0003677,GO:0003684,GO:0003691,GO:0003713,GO:0003714,GO:0003723,GO:0003906,GO:0004519,GO:0004520,GO:0004523,GO:0004528,GO:0004844,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005737,GO:0005739,GO:0005783,GO:0005813,GO:0005840,GO:0006281,GO:0006284,GO:0006286,GO:0006310,GO:0007568,GO:0008081,GO:0008309,GO:0008311,GO:0008408,GO:0014912,GO:0016491,GO:0016607,GO:0016890,GO:0031490,GO:0042493,GO:0042981,GO:0043488,GO:0044877,GO:0045454,GO:0045892,GO:0045944,GO:0046872,GO:0048471,GO:0051059,GO:0055114,GO:0070301,GO:0071320,GO:0071375,GO:0080111,GO:0090502,GO:0097698,GO:1900087" "telomere maintenance|chromosome, telomeric region|DNA binding|damaged DNA binding|double-stranded telomeric DNA binding|transcription coactivator activity|transcription corepressor activity|RNA binding|DNA-(apurinic or apyrimidinic site) endonuclease activity|endonuclease activity|endodeoxyribonuclease activity|RNA-DNA hybrid ribonuclease activity|phosphodiesterase I activity|uracil DNA N-glycosylase activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytoplasm|mitochondrion|endoplasmic reticulum|centrosome|ribosome|DNA repair|base-excision repair|base-excision repair, base-free sugar-phosphate removal|DNA recombination|aging|phosphoric diester hydrolase activity|double-stranded DNA exodeoxyribonuclease activity|double-stranded DNA 3'-5' exodeoxyribonuclease activity|3'-5' exonuclease activity|negative regulation of smooth muscle cell migration|oxidoreductase activity|nuclear speck|site-specific endodeoxyribonuclease activity, specific for altered base|chromatin DNA binding|response to drug|regulation of apoptotic process|regulation of mRNA stability|protein-containing complex binding|cell redox homeostasis|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|perinuclear region of cytoplasm|NF-kappaB binding|oxidation-reduction process|cellular response to hydrogen peroxide|cellular response to cAMP|cellular response to peptide hormone stimulus|DNA demethylation|RNA phosphodiester bond hydrolysis, endonucleolytic|telomere maintenance via base-excision repair|positive regulation of G1/S transition of mitotic cell cycle" hsa03410 Base excision repair APEX2 961.6706335 909.3217334 1014.019534 1.115138346 0.157222704 0.525689867 1 14.98265812 16.42815525 27301 apurinic/apyrimidinic endodeoxyribonuclease 2 "GO:0001650,GO:0003677,GO:0003906,GO:0004519,GO:0004528,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006284,GO:0006310,GO:0007049,GO:0008270,GO:0008311,GO:0043231,GO:0090305" fibrillar center|DNA binding|DNA-(apurinic or apyrimidinic site) endonuclease activity|endonuclease activity|phosphodiesterase I activity|protein binding|nucleus|nucleoplasm|mitochondrion|base-excision repair|DNA recombination|cell cycle|zinc ion binding|double-stranded DNA 3'-5' exodeoxyribonuclease activity|intracellular membrane-bounded organelle|nucleic acid phosphodiester bond hydrolysis hsa03410 Base excision repair APH1A 2788.415113 2828.885347 2747.944878 0.971387858 -0.041880641 0.860829164 1 62.41108379 59.61088556 51107 "aph-1 homolog A, gamma-secretase subunit" "GO:0001656,GO:0004175,GO:0005515,GO:0005739,GO:0005769,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005887,GO:0006509,GO:0007219,GO:0007220,GO:0008021,GO:0010008,GO:0010950,GO:0016020,GO:0016021,GO:0016485,GO:0019899,GO:0030674,GO:0031293,GO:0032580,GO:0034205,GO:0035333,GO:0042982,GO:0042987,GO:0043065,GO:0043085,GO:0044267,GO:0048013,GO:0061133,GO:0070765,GO:0099056" "metanephros development|endopeptidase activity|protein binding|mitochondrion|early endosome|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|membrane protein ectodomain proteolysis|Notch signaling pathway|Notch receptor processing|synaptic vesicle|endosome membrane|positive regulation of endopeptidase activity|membrane|integral component of membrane|protein processing|enzyme binding|protein-macromolecule adaptor activity|membrane protein intracellular domain proteolysis|Golgi cisterna membrane|amyloid-beta formation|Notch receptor processing, ligand-dependent|amyloid precursor protein metabolic process|amyloid precursor protein catabolic process|positive regulation of apoptotic process|positive regulation of catalytic activity|cellular protein metabolic process|ephrin receptor signaling pathway|endopeptidase activator activity|gamma-secretase complex|integral component of presynaptic membrane" "hsa04330,hsa05010" Notch signaling pathway|Alzheimer disease APH1B 561.9259481 571.1872216 552.6646747 0.967571847 -0.047559303 0.864711243 1 6.315146513 6.008109407 83464 "aph-1 homolog B, gamma-secretase subunit" "GO:0004175,GO:0005515,GO:0005783,GO:0005886,GO:0005887,GO:0007219,GO:0007220,GO:0007626,GO:0008233,GO:0010008,GO:0010950,GO:0016021,GO:0016485,GO:0030133,GO:0030674,GO:0031293,GO:0034205,GO:0035333,GO:0042987,GO:0043065,GO:0044267,GO:0048013,GO:0061133,GO:0070765" "endopeptidase activity|protein binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|Notch signaling pathway|Notch receptor processing|locomotory behavior|peptidase activity|endosome membrane|positive regulation of endopeptidase activity|integral component of membrane|protein processing|transport vesicle|protein-macromolecule adaptor activity|membrane protein intracellular domain proteolysis|amyloid-beta formation|Notch receptor processing, ligand-dependent|amyloid precursor protein catabolic process|positive regulation of apoptotic process|cellular protein metabolic process|ephrin receptor signaling pathway|endopeptidase activator activity|gamma-secretase complex" "hsa04330,hsa05010" Notch signaling pathway|Alzheimer disease API5 3666.783438 3544.690098 3788.876779 1.068888019 0.096110719 0.686474526 1 27.01708022 28.39499524 8539 apoptosis inhibitor 5 "GO:0003723,GO:0005515,GO:0005634,GO:0005681,GO:0005737,GO:0006915,GO:0016020,GO:0016607,GO:0017134,GO:0043066,GO:2000270" RNA binding|protein binding|nucleus|spliceosomal complex|cytoplasm|apoptotic process|membrane|nuclear speck|fibroblast growth factor binding|negative regulation of apoptotic process|negative regulation of fibroblast apoptotic process APIP 849.3896081 775.1083426 923.6708737 1.191666794 0.252980896 0.311972442 1 28.50868894 33.40436819 51074 APAF1 interacting protein "GO:0005515,GO:0005737,GO:0005829,GO:0006915,GO:0008270,GO:0019284,GO:0019509,GO:0042802,GO:0043066,GO:0046570,GO:0051289,GO:0070269,GO:0070372" protein binding|cytoplasm|cytosol|apoptotic process|zinc ion binding|L-methionine salvage from S-adenosylmethionine|L-methionine salvage from methylthioadenosine|identical protein binding|negative regulation of apoptotic process|methylthioribulose 1-phosphate dehydratase activity|protein homotetramerization|pyroptosis|regulation of ERK1 and ERK2 cascade hsa00270 Cysteine and methionine metabolism APLF 129.3094602 114.4455271 144.1733934 1.259755598 0.333143867 0.442027 1 1.597632079 1.978947385 200558 aprataxin and PNKP like factor "GO:0000012,GO:0000166,GO:0003906,GO:0004520,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006302,GO:0006974,GO:0008408,GO:0035861,GO:0046872,GO:0051106,GO:0090305" single strand break repair|nucleotide binding|DNA-(apurinic or apyrimidinic site) endonuclease activity|endodeoxyribonuclease activity|protein binding|nucleus|nucleoplasm|cytosol|double-strand break repair|cellular response to DNA damage stimulus|3'-5' exonuclease activity|site of double-strand break|metal ion binding|positive regulation of DNA ligation|nucleic acid phosphodiester bond hydrolysis APLN 85.79010032 82.19269673 89.38750391 1.087535845 0.121062953 0.827752931 1 1.360568598 1.454906895 8862 apelin "GO:0001525,GO:0002026,GO:0005102,GO:0005179,GO:0005576,GO:0005615,GO:0006955,GO:0007165,GO:0007186,GO:0007369,GO:0007595,GO:0010629,GO:0016032,GO:0031652,GO:0031704,GO:0040037,GO:0042327,GO:0042756,GO:0042802,GO:0043576,GO:0045776,GO:0045823,GO:0045906,GO:0048471,GO:0051461,GO:0051466,GO:0060183,GO:0060976,GO:1902895,GO:1904022,GO:1904706,GO:1905564" angiogenesis|regulation of the force of heart contraction|signaling receptor binding|hormone activity|extracellular region|extracellular space|immune response|signal transduction|G protein-coupled receptor signaling pathway|gastrulation|lactation|negative regulation of gene expression|viral process|positive regulation of heat generation|apelin receptor binding|negative regulation of fibroblast growth factor receptor signaling pathway|positive regulation of phosphorylation|drinking behavior|identical protein binding|regulation of respiratory gaseous exchange|negative regulation of blood pressure|positive regulation of heart contraction|negative regulation of vasoconstriction|perinuclear region of cytoplasm|positive regulation of corticotropin secretion|positive regulation of corticotropin-releasing hormone secretion|apelin receptor signaling pathway|coronary vasculature development|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of G protein-coupled receptor internalization|negative regulation of vascular associated smooth muscle cell proliferation|positive regulation of vascular endothelial cell proliferation "hsa04080,hsa04371" Neuroactive ligand-receptor interaction|Apelin signaling pathway APLP2 17350.42928 16493.68128 18207.17727 1.103888026 0.142593839 0.594227918 1 224.9520715 244.1665676 334 amyloid beta precursor like protein 2 "GO:0002576,GO:0003677,GO:0004867,GO:0005515,GO:0005634,GO:0005788,GO:0005886,GO:0007186,GO:0008201,GO:0010951,GO:0016020,GO:0016021,GO:0031092,GO:0042802,GO:0043687,GO:0044267,GO:0046914,GO:0070062" platelet degranulation|DNA binding|serine-type endopeptidase inhibitor activity|protein binding|nucleus|endoplasmic reticulum lumen|plasma membrane|G protein-coupled receptor signaling pathway|heparin binding|negative regulation of endopeptidase activity|membrane|integral component of membrane|platelet alpha granule membrane|identical protein binding|post-translational protein modification|cellular protein metabolic process|transition metal ion binding|extracellular exosome APMAP 3094.106752 2918.360941 3269.852562 1.120441449 0.16406726 0.488805426 1 70.73004527 77.92275185 57136 adipocyte plasma membrane associated protein "GO:0004064,GO:0005515,GO:0008150,GO:0009058,GO:0009986,GO:0016020,GO:0016021,GO:0016844" arylesterase activity|protein binding|biological_process|biosynthetic process|cell surface|membrane|integral component of membrane|strictosidine synthase activity APOBEC3B 968.9283786 986.3123607 951.5443964 0.96474954 -0.051773644 0.837455087 1 33.10545782 31.40402807 9582 apolipoprotein B mRNA editing enzyme catalytic subunit 3B "GO:0000932,GO:0003723,GO:0004126,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008270,GO:0009972,GO:0010529,GO:0016554,GO:0045087,GO:0045869,GO:0047844,GO:0051607,GO:0070383,GO:0080111" P-body|RNA binding|cytidine deaminase activity|protein binding|nucleus|nucleoplasm|cytoplasm|zinc ion binding|cytidine deamination|negative regulation of transposition|cytidine to uridine editing|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|deoxycytidine deaminase activity|defense response to virus|DNA cytosine deamination|DNA demethylation hsa05170 Human immunodeficiency virus 1 infection APOBEC3C 1061.54595 1020.646019 1102.445882 1.080145184 0.11122524 0.651566161 1 20.4390252 21.70768401 27350 apolipoprotein B mRNA editing enzyme catalytic subunit 3C "GO:0000932,GO:0003723,GO:0004126,GO:0005515,GO:0005634,GO:0005737,GO:0008270,GO:0009972,GO:0010529,GO:0016032,GO:0016554,GO:0045071,GO:0045087,GO:0045869,GO:0047844,GO:0051607,GO:0070383,GO:0080111" P-body|RNA binding|cytidine deaminase activity|protein binding|nucleus|cytoplasm|zinc ion binding|cytidine deamination|negative regulation of transposition|viral process|cytidine to uridine editing|negative regulation of viral genome replication|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|deoxycytidine deaminase activity|defense response to virus|DNA cytosine deamination|DNA demethylation hsa05170 Human immunodeficiency virus 1 infection APOBEC3D 158.5203069 174.7895323 142.2510815 0.813842108 -0.297179167 0.459573626 1 3.476778266 2.782199892 140564 apolipoprotein B mRNA editing enzyme catalytic subunit 3D "GO:0000932,GO:0003723,GO:0004126,GO:0005634,GO:0005737,GO:0008270,GO:0009972,GO:0010529,GO:0016554,GO:0045087,GO:0045869,GO:0047844,GO:0051607,GO:0070383,GO:0080111" P-body|RNA binding|cytidine deaminase activity|nucleus|cytoplasm|zinc ion binding|cytidine deamination|negative regulation of transposition|cytidine to uridine editing|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|deoxycytidine deaminase activity|defense response to virus|DNA cytosine deamination|DNA demethylation hsa05170 Human immunodeficiency virus 1 infection APOBEC3F 118.3354247 116.5263549 120.1444945 1.031049968 0.044114253 0.940962223 1 0.798612738 0.809630993 200316 apolipoprotein B mRNA editing enzyme catalytic subunit 3F "GO:0000932,GO:0002230,GO:0003723,GO:0004126,GO:0005515,GO:0005634,GO:0005737,GO:0008270,GO:0009972,GO:0010529,GO:0016553,GO:0016554,GO:0030895,GO:0042802,GO:0045071,GO:0045087,GO:0045869,GO:0047844,GO:0048525,GO:0051607,GO:0070383,GO:0080111,GO:1990904" P-body|positive regulation of defense response to virus by host|RNA binding|cytidine deaminase activity|protein binding|nucleus|cytoplasm|zinc ion binding|cytidine deamination|negative regulation of transposition|base conversion or substitution editing|cytidine to uridine editing|apolipoprotein B mRNA editing enzyme complex|identical protein binding|negative regulation of viral genome replication|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|deoxycytidine deaminase activity|negative regulation of viral process|defense response to virus|DNA cytosine deamination|DNA demethylation|ribonucleoprotein complex hsa05170 Human immunodeficiency virus 1 infection APOBEC3G 180.5872649 173.7491184 187.4254114 1.078712877 0.109310911 0.78483045 1 2.708139927 2.872421323 60489 apolipoprotein B mRNA editing enzyme catalytic subunit 3G "GO:0000932,GO:0002230,GO:0003723,GO:0004126,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0008270,GO:0009972,GO:0010529,GO:0016032,GO:0016553,GO:0016554,GO:0030895,GO:0042802,GO:0045071,GO:0045087,GO:0045869,GO:0047844,GO:0048525,GO:0051607,GO:0070383,GO:0080111,GO:1990904" P-body|positive regulation of defense response to virus by host|RNA binding|cytidine deaminase activity|protein binding|nucleus|cytoplasm|cytosol|zinc ion binding|cytidine deamination|negative regulation of transposition|viral process|base conversion or substitution editing|cytidine to uridine editing|apolipoprotein B mRNA editing enzyme complex|identical protein binding|negative regulation of viral genome replication|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|deoxycytidine deaminase activity|negative regulation of viral process|defense response to virus|DNA cytosine deamination|DNA demethylation|ribonucleoprotein complex hsa05170 Human immunodeficiency virus 1 infection APOC1 7.486072413 7.282897178 7.689247648 1.055795168 0.078329968 1 1 0.471692763 0.489677402 341 apolipoprotein C1 "GO:0004859,GO:0005504,GO:0005515,GO:0005576,GO:0005783,GO:0006629,GO:0006641,GO:0010873,GO:0010900,GO:0010916,GO:0031210,GO:0032374,GO:0032375,GO:0033344,GO:0033700,GO:0034361,GO:0034364,GO:0034369,GO:0034375,GO:0034379,GO:0034382,GO:0034447,GO:0042157,GO:0042627,GO:0045717,GO:0045833,GO:0048261,GO:0050995,GO:0051005,GO:0055102,GO:0060228" phospholipase inhibitor activity|fatty acid binding|protein binding|extracellular region|endoplasmic reticulum|lipid metabolic process|triglyceride metabolic process|positive regulation of cholesterol esterification|negative regulation of phosphatidylcholine catabolic process|negative regulation of very-low-density lipoprotein particle clearance|phosphatidylcholine binding|regulation of cholesterol transport|negative regulation of cholesterol transport|cholesterol efflux|phospholipid efflux|very-low-density lipoprotein particle|high-density lipoprotein particle|plasma lipoprotein particle remodeling|high-density lipoprotein particle remodeling|very-low-density lipoprotein particle assembly|chylomicron remnant clearance|very-low-density lipoprotein particle clearance|lipoprotein metabolic process|chylomicron|negative regulation of fatty acid biosynthetic process|negative regulation of lipid metabolic process|negative regulation of receptor-mediated endocytosis|negative regulation of lipid catabolic process|negative regulation of lipoprotein lipase activity|lipase inhibitor activity|phosphatidylcholine-sterol O-acyltransferase activator activity hsa04979 Cholesterol metabolism APOE 6.287142677 1.040413883 11.53387147 11.08584926 3.470647391 0.047314597 1 0.041779516 0.455411037 348 apolipoprotein E "GO:0000302,GO:0001523,GO:0001540,GO:0001937,GO:0002021,GO:0005102,GO:0005198,GO:0005319,GO:0005515,GO:0005543,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005769,GO:0005783,GO:0005788,GO:0005794,GO:0005886,GO:0006357,GO:0006641,GO:0006707,GO:0006874,GO:0006898,GO:0007010,GO:0007186,GO:0007263,GO:0007271,GO:0007616,GO:0008201,GO:0008203,GO:0008289,GO:0010467,GO:0010544,GO:0010596,GO:0010629,GO:0010873,GO:0010875,GO:0010877,GO:0010976,GO:0010977,GO:0015909,GO:0016020,GO:0016209,GO:0017038,GO:0019068,GO:0019934,GO:0030195,GO:0030425,GO:0030516,GO:0030669,GO:0031012,GO:0031175,GO:0032269,GO:0032489,GO:0032805,GO:0033344,GO:0033700,GO:0034361,GO:0034362,GO:0034363,GO:0034364,GO:0034365,GO:0034371,GO:0034372,GO:0034374,GO:0034375,GO:0034378,GO:0034380,GO:0034382,GO:0034384,GO:0034447,GO:0035641,GO:0042158,GO:0042159,GO:0042311,GO:0042627,GO:0042632,GO:0042802,GO:0042803,GO:0042982,GO:0043025,GO:0043083,GO:0043254,GO:0043395,GO:0043407,GO:0043524,GO:0043537,GO:0043687,GO:0043691,GO:0044267,GO:0044794,GO:0044877,GO:0045088,GO:0045541,GO:0045807,GO:0045893,GO:0046889,GO:0046907,GO:0046911,GO:0046983,GO:0048156,GO:0048168,GO:0048844,GO:0050709,GO:0050728,GO:0050750,GO:0051000,GO:0051044,GO:0051246,GO:0051651,GO:0055089,GO:0060228,GO:0060999,GO:0061136,GO:0061771,GO:0062023,GO:0070062,GO:0070326,GO:0070328,GO:0070374,GO:0071682,GO:0071813,GO:0071830,GO:0071831,GO:0072562,GO:0090090,GO:0090181,GO:0090209,GO:0097113,GO:0097114,GO:0098869,GO:0098978,GO:0120009,GO:0120020,GO:1900221,GO:1900223,GO:1900272,GO:1902430,GO:1902952,GO:1902991,GO:1902995,GO:1903002,GO:1903561,GO:1905855,GO:1905860,GO:1905890,GO:1905906,GO:1905907,GO:1905908,GO:1990777,GO:2000822" "response to reactive oxygen species|retinoid metabolic process|amyloid-beta binding|negative regulation of endothelial cell proliferation|response to dietary excess|signaling receptor binding|structural molecule activity|lipid transporter activity|protein binding|phospholipid binding|extracellular region|extracellular space|nucleus|cytoplasm|early endosome|endoplasmic reticulum|endoplasmic reticulum lumen|Golgi apparatus|plasma membrane|regulation of transcription by RNA polymerase II|triglyceride metabolic process|cholesterol catabolic process|cellular calcium ion homeostasis|receptor-mediated endocytosis|cytoskeleton organization|G protein-coupled receptor signaling pathway|nitric oxide mediated signal transduction|synaptic transmission, cholinergic|long-term memory|heparin binding|cholesterol metabolic process|lipid binding|gene expression|negative regulation of platelet activation|negative regulation of endothelial cell migration|negative regulation of gene expression|positive regulation of cholesterol esterification|positive regulation of cholesterol efflux|lipid transport involved in lipid storage|positive regulation of neuron projection development|negative regulation of neuron projection development|long-chain fatty acid transport|membrane|antioxidant activity|protein import|virion assembly|cGMP-mediated signaling|negative regulation of blood coagulation|dendrite|regulation of axon extension|clathrin-coated endocytic vesicle membrane|extracellular matrix|neuron projection development|negative regulation of cellular protein metabolic process|regulation of Cdc42 protein signal transduction|positive regulation of low-density lipoprotein particle receptor catabolic process|cholesterol efflux|phospholipid efflux|very-low-density lipoprotein particle|low-density lipoprotein particle|intermediate-density lipoprotein particle|high-density lipoprotein particle|discoidal high-density lipoprotein particle|chylomicron remodeling|very-low-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|high-density lipoprotein particle remodeling|chylomicron assembly|high-density lipoprotein particle assembly|chylomicron remnant clearance|high-density lipoprotein particle clearance|very-low-density lipoprotein particle clearance|locomotory exploration behavior|lipoprotein biosynthetic process|lipoprotein catabolic process|vasodilation|chylomicron|cholesterol homeostasis|identical protein binding|protein homodimerization activity|amyloid precursor protein metabolic process|neuronal cell body|synaptic cleft|regulation of protein-containing complex assembly|heparan sulfate proteoglycan binding|negative regulation of MAP kinase activity|negative regulation of neuron apoptotic process|negative regulation of blood vessel endothelial cell migration|post-translational protein modification|reverse cholesterol transport|cellular protein metabolic process|positive regulation by host of viral process|protein-containing complex binding|regulation of innate immune response|negative regulation of cholesterol biosynthetic process|positive regulation of endocytosis|positive regulation of transcription, DNA-templated|positive regulation of lipid biosynthetic process|intracellular transport|metal chelating activity|protein dimerization activity|tau protein binding|regulation of neuronal synaptic plasticity|artery morphogenesis|negative regulation of protein secretion|negative regulation of inflammatory response|low-density lipoprotein particle receptor binding|positive regulation of nitric-oxide synthase activity|positive regulation of membrane protein ectodomain proteolysis|regulation of protein metabolic process|maintenance of location in cell|fatty acid homeostasis|phosphatidylcholine-sterol O-acyltransferase activator activity|positive regulation of dendritic spine development|regulation of proteasomal protein catabolic process|response to caloric restriction|collagen-containing extracellular matrix|extracellular exosome|very-low-density lipoprotein particle receptor binding|triglyceride homeostasis|positive regulation of ERK1 and ERK2 cascade|endocytic vesicle lumen|lipoprotein particle binding|triglyceride-rich lipoprotein particle clearance|intermediate-density lipoprotein particle clearance|blood microparticle|negative regulation of canonical Wnt signaling pathway|regulation of cholesterol metabolic process|negative regulation of triglyceride metabolic process|AMPA glutamate receptor clustering|NMDA glutamate receptor clustering|cellular oxidant detoxification|glutamatergic synapse|intermembrane lipid transfer|cholesterol transfer activity|regulation of amyloid-beta clearance|positive regulation of amyloid-beta clearance|negative regulation of long-term synaptic potentiation|negative regulation of amyloid-beta formation|positive regulation of dendritic spine maintenance|regulation of amyloid precursor protein catabolic process|positive regulation of phospholipid efflux|positive regulation of lipid transport across blood-brain barrier|extracellular vesicle|positive regulation of heparan sulfate binding|positive regulation of heparan sulfate proteoglycan binding|regulation of cellular response to very-low-density lipoprotein particle stimulus|regulation of amyloid fibril formation|negative regulation of amyloid fibril formation|positive regulation of amyloid fibril formation|lipoprotein particle|regulation of behavioral fear response" "hsa04979,hsa05010" Cholesterol metabolism|Alzheimer disease APOL1 306.7654227 306.9220954 306.60875 0.998979072 -0.00147364 1 1 5.058637471 4.968909939 8542 apolipoprotein L1 "GO:0005254,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0006869,GO:0006898,GO:0008203,GO:0008289,GO:0031224,GO:0034361,GO:0034364,GO:0042157,GO:0043687,GO:0044267,GO:0045087,GO:0051838,GO:0072562,GO:1902476" chloride channel activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|lipid transport|receptor-mediated endocytosis|cholesterol metabolic process|lipid binding|intrinsic component of membrane|very-low-density lipoprotein particle|high-density lipoprotein particle|lipoprotein metabolic process|post-translational protein modification|cellular protein metabolic process|innate immune response|cytolysis by host of symbiont cells|blood microparticle|chloride transmembrane transport hsa05143 African trypanosomiasis APOL2 351.6818572 350.6194785 352.7442358 1.00606001 0.008716362 0.987623278 1 5.142049232 5.086643434 23780 apolipoprotein L2 "GO:0005102,GO:0005515,GO:0005576,GO:0005789,GO:0006629,GO:0006869,GO:0006953,GO:0007275,GO:0008035,GO:0008203,GO:0008289,GO:0016020,GO:0042157,GO:0060135" signaling receptor binding|protein binding|extracellular region|endoplasmic reticulum membrane|lipid metabolic process|lipid transport|acute-phase response|multicellular organism development|high-density lipoprotein particle binding|cholesterol metabolic process|lipid binding|membrane|lipoprotein metabolic process|maternal process involved in female pregnancy APOL3 30.74189934 37.45489978 24.0288989 0.641542203 -0.640383922 0.38284597 1 0.404635458 0.255246824 80833 apolipoprotein L3 "GO:0005319,GO:0005576,GO:0005737,GO:0006869,GO:0006954,GO:0008289,GO:0016020,GO:0042157,GO:0043123" lipid transporter activity|extracellular region|cytoplasm|lipid transport|inflammatory response|lipid binding|membrane|lipoprotein metabolic process|positive regulation of I-kappaB kinase/NF-kappaB signaling APOL6 960.9856515 1118.444924 803.5263792 0.718431782 -0.477076922 0.05313158 1 5.788338826 4.088939264 80830 apolipoprotein L6 "GO:0005515,GO:0005576,GO:0005737,GO:0006869,GO:0008289,GO:0042157" protein binding|extracellular region|cytoplasm|lipid transport|lipid binding|lipoprotein metabolic process APOLD1 160.4375884 187.2744989 133.6006779 0.713394929 -0.487227134 0.21852873 1 2.093526562 1.468519346 81575 apolipoprotein L domain containing 1 "GO:0001525,GO:0001666,GO:0005576,GO:0005886,GO:0006869,GO:0008289,GO:0016021,GO:0030154,GO:0042118,GO:0042157,GO:0045601" angiogenesis|response to hypoxia|extracellular region|plasma membrane|lipid transport|lipid binding|integral component of membrane|cell differentiation|endothelial cell activation|lipoprotein metabolic process|regulation of endothelial cell differentiation APOM 12.80702872 20.80827765 4.80577978 0.230955193 -2.11431511 0.047879459 1 1.212335736 0.275309893 55937 apolipoprotein M "GO:0001523,GO:0005319,GO:0005543,GO:0005576,GO:0009749,GO:0016209,GO:0033344,GO:0034361,GO:0034362,GO:0034364,GO:0034365,GO:0034366,GO:0034375,GO:0034380,GO:0034384,GO:0034445,GO:0042157,GO:0042632,GO:0043691,GO:0098869" retinoid metabolic process|lipid transporter activity|phospholipid binding|extracellular region|response to glucose|antioxidant activity|cholesterol efflux|very-low-density lipoprotein particle|low-density lipoprotein particle|high-density lipoprotein particle|discoidal high-density lipoprotein particle|spherical high-density lipoprotein particle|high-density lipoprotein particle remodeling|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|negative regulation of plasma lipoprotein oxidation|lipoprotein metabolic process|cholesterol homeostasis|reverse cholesterol transport|cellular oxidant detoxification APOO 279.7593211 241.3760208 318.1426214 1.318037394 0.398391302 0.217940859 1 7.902941471 10.2420685 79135 apolipoprotein O "GO:0000139,GO:0001401,GO:0005515,GO:0005576,GO:0005615,GO:0005739,GO:0005789,GO:0005829,GO:0006869,GO:0007007,GO:0031305,GO:0034361,GO:0034362,GO:0034364,GO:0042407,GO:0061617,GO:0140275" Golgi membrane|SAM complex|protein binding|extracellular region|extracellular space|mitochondrion|endoplasmic reticulum membrane|cytosol|lipid transport|inner mitochondrial membrane organization|integral component of mitochondrial inner membrane|very-low-density lipoprotein particle|low-density lipoprotein particle|high-density lipoprotein particle|cristae formation|MICOS complex|MIB complex APOOL 221.624477 203.921121 239.327833 1.17362945 0.230976978 0.514527906 1 9.455165453 10.91116969 139322 apolipoprotein O like "GO:0001401,GO:0002576,GO:0005515,GO:0005576,GO:0005739,GO:0007007,GO:0031093,GO:0042407,GO:0061617,GO:0140275" SAM complex|platelet degranulation|protein binding|extracellular region|mitochondrion|inner mitochondrial membrane organization|platelet alpha granule lumen|cristae formation|MICOS complex|MIB complex APP 21495.6187 20359.85927 22631.37814 1.111568496 0.152596851 0.58067821 1 273.0071029 298.3880005 351 amyloid beta precursor protein "GO:0000978,GO:0001774,GO:0001934,GO:0001967,GO:0002265,GO:0002576,GO:0003677,GO:0004867,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005641,GO:0005737,GO:0005768,GO:0005769,GO:0005788,GO:0005790,GO:0005791,GO:0005794,GO:0005796,GO:0005798,GO:0005829,GO:0005886,GO:0005887,GO:0005905,GO:0005911,GO:0006378,GO:0006417,GO:0006468,GO:0006878,GO:0006897,GO:0006979,GO:0007155,GO:0007176,GO:0007186,GO:0007219,GO:0007409,GO:0007611,GO:0007612,GO:0007617,GO:0007626,GO:0008021,GO:0008088,GO:0008201,GO:0008203,GO:0008285,GO:0008344,GO:0008542,GO:0009986,GO:0009987,GO:0010288,GO:0010468,GO:0010628,GO:0010629,GO:0010800,GO:0010951,GO:0010952,GO:0010971,GO:0014005,GO:0016021,GO:0016199,GO:0016322,GO:0016358,GO:0016504,GO:0019899,GO:0030111,GO:0030134,GO:0030198,GO:0030424,GO:0030546,GO:0030900,GO:0031093,GO:0031175,GO:0031594,GO:0031904,GO:0032092,GO:0032588,GO:0032722,GO:0032731,GO:0032755,GO:0032760,GO:0033138,GO:0035235,GO:0035253,GO:0040014,GO:0042327,GO:0042802,GO:0043197,GO:0043198,GO:0043204,GO:0043235,GO:0043687,GO:0044267,GO:0044304,GO:0045087,GO:0045121,GO:0045177,GO:0045202,GO:0045665,GO:0045821,GO:0045931,GO:0045944,GO:0046330,GO:0046914,GO:0048143,GO:0048169,GO:0048471,GO:0048669,GO:0048786,GO:0050729,GO:0050730,GO:0050803,GO:0050808,GO:0050885,GO:0050890,GO:0051091,GO:0051092,GO:0051124,GO:0051233,GO:0051247,GO:0051402,GO:0051425,GO:0051563,GO:0055037,GO:0070062,GO:0070374,GO:0070555,GO:0070851,GO:0071280,GO:0071287,GO:0071320,GO:0071874,GO:0090647,GO:0097449,GO:0098815,GO:0150003,GO:1900272,GO:1900273,GO:1901224,GO:1904646,GO:1905598,GO:1905606,GO:1905908,GO:1990000,GO:1990090,GO:1990535,GO:1990761,GO:1990812,GO:2000310,GO:2000406" RNA polymerase II cis-regulatory region sequence-specific DNA binding|microglial cell activation|positive regulation of protein phosphorylation|suckling behavior|astrocyte activation involved in immune response|platelet degranulation|DNA binding|serine-type endopeptidase inhibitor activity|signaling receptor binding|protein binding|extracellular region|extracellular space|nuclear envelope lumen|cytoplasm|endosome|early endosome|endoplasmic reticulum lumen|smooth endoplasmic reticulum|rough endoplasmic reticulum|Golgi apparatus|Golgi lumen|Golgi-associated vesicle|cytosol|plasma membrane|integral component of plasma membrane|clathrin-coated pit|cell-cell junction|mRNA polyadenylation|regulation of translation|protein phosphorylation|cellular copper ion homeostasis|endocytosis|response to oxidative stress|cell adhesion|regulation of epidermal growth factor-activated receptor activity|G protein-coupled receptor signaling pathway|Notch signaling pathway|axonogenesis|learning or memory|learning|mating behavior|locomotory behavior|synaptic vesicle|axo-dendritic transport|heparin binding|cholesterol metabolic process|negative regulation of cell population proliferation|adult locomotory behavior|visual learning|cell surface|cellular process|response to lead ion|regulation of gene expression|positive regulation of gene expression|negative regulation of gene expression|positive regulation of peptidyl-threonine phosphorylation|negative regulation of endopeptidase activity|positive regulation of peptidase activity|positive regulation of G2/M transition of mitotic cell cycle|microglia development|integral component of membrane|axon midline choice point recognition|neuron remodeling|dendrite development|peptidase activator activity|enzyme binding|regulation of Wnt signaling pathway|COPII-coated ER to Golgi transport vesicle|extracellular matrix organization|axon|signaling receptor activator activity|forebrain development|platelet alpha granule lumen|neuron projection development|neuromuscular junction|endosome lumen|positive regulation of protein binding|trans-Golgi network membrane|positive regulation of chemokine production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of peptidyl-serine phosphorylation|ionotropic glutamate receptor signaling pathway|ciliary rootlet|regulation of multicellular organism growth|positive regulation of phosphorylation|identical protein binding|dendritic spine|dendritic shaft|perikaryon|receptor complex|post-translational protein modification|cellular protein metabolic process|main axon|innate immune response|membrane raft|apical part of cell|synapse|negative regulation of neuron differentiation|positive regulation of glycolytic process|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|transition metal ion binding|astrocyte activation|regulation of long-term neuronal synaptic plasticity|perinuclear region of cytoplasm|collateral sprouting in absence of injury|presynaptic active zone|positive regulation of inflammatory response|regulation of peptidyl-tyrosine phosphorylation|regulation of synapse structure or activity|synapse organization|neuromuscular process controlling balance|cognition|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|synaptic growth at neuromuscular junction|spindle midzone|positive regulation of protein metabolic process|neuron apoptotic process|PTB domain binding|smooth endoplasmic reticulum calcium ion homeostasis|recycling endosome|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|response to interleukin-1|growth factor receptor binding|cellular response to copper ion|cellular response to manganese ion|cellular response to cAMP|cellular response to norepinephrine stimulus|modulation of age-related behavioral decline|astrocyte projection|modulation of excitatory postsynaptic potential|regulation of spontaneous synaptic transmission|negative regulation of long-term synaptic potentiation|positive regulation of long-term synaptic potentiation|positive regulation of NIK/NF-kappaB signaling|cellular response to amyloid-beta|negative regulation of low-density lipoprotein receptor activity|regulation of presynapse assembly|positive regulation of amyloid fibril formation|amyloid fibril formation|cellular response to nerve growth factor stimulus|neuron projection maintenance|growth cone lamellipodium|growth cone filopodium|regulation of NMDA receptor activity|positive regulation of T cell migration "hsa04726,hsa05010,hsa05022" Serotonergic synapse|Alzheimer disease|Pathways of neurodegeneration - multiple diseases APPBP2 1560.297302 1737.491184 1383.103421 0.796034785 -0.329096621 0.167098209 1 14.2001089 11.11462717 10513 amyloid beta precursor protein binding protein 2 "GO:0003777,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005874,GO:0005875,GO:0006886,GO:0030659,GO:0046907" microtubule motor activity|protein binding|nucleus|nucleoplasm|cytoplasm|microtubule|microtubule associated complex|intracellular protein transport|cytoplasmic vesicle membrane|intracellular transport APPL1 1757.344334 1712.521251 1802.167417 1.052347477 0.07361115 0.758153661 1 14.92636153 15.4448715 26060 "adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1" "GO:0001726,GO:0001786,GO:0005515,GO:0005634,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0006606,GO:0007049,GO:0007165,GO:0007179,GO:0008286,GO:0010008,GO:0010762,GO:0012506,GO:0016020,GO:0023052,GO:0031410,GO:0031901,GO:0032009,GO:0033211,GO:0034143,GO:0035091,GO:0035729,GO:0042802,GO:0042803,GO:0043422,GO:0044354,GO:0044877,GO:0045088,GO:0046324,GO:0046326,GO:0048023,GO:0048487,GO:0070062,GO:0097192,GO:0097708,GO:1900017,GO:1903076,GO:1905303,GO:1905450,GO:2000045" ruffle|phosphatidylserine binding|protein binding|nucleus|cytoplasm|endosome|early endosome|cytosol|plasma membrane|protein import into nucleus|cell cycle|signal transduction|transforming growth factor beta receptor signaling pathway|insulin receptor signaling pathway|endosome membrane|regulation of fibroblast migration|vesicle membrane|membrane|signaling|cytoplasmic vesicle|early endosome membrane|early phagosome|adiponectin-activated signaling pathway|regulation of toll-like receptor 4 signaling pathway|phosphatidylinositol binding|cellular response to hepatocyte growth factor stimulus|identical protein binding|protein homodimerization activity|protein kinase B binding|macropinosome|protein-containing complex binding|regulation of innate immune response|regulation of glucose import|positive regulation of glucose import|positive regulation of melanin biosynthetic process|beta-tubulin binding|extracellular exosome|extrinsic apoptotic signaling pathway in absence of ligand|intracellular vesicle|positive regulation of cytokine production involved in inflammatory response|regulation of protein localization to plasma membrane|positive regulation of macropinocytosis|negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of G1/S transition of mitotic cell cycle "hsa04211,hsa05200,hsa05210" Longevity regulating pathway|Pathways in cancer|Colorectal cancer APPL2 1539.416026 1479.468541 1599.363511 1.081039215 0.112418859 0.638710459 1 10.17218718 10.81252116 55198 "adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2" "GO:0001726,GO:0001786,GO:0002024,GO:0005515,GO:0005634,GO:0005768,GO:0005886,GO:0006606,GO:0007049,GO:0007165,GO:0007179,GO:0009631,GO:0010008,GO:0010762,GO:0016020,GO:0023052,GO:0031410,GO:0031901,GO:0031982,GO:0032009,GO:0032587,GO:0033211,GO:0034143,GO:0035091,GO:0035729,GO:0036186,GO:0042593,GO:0042802,GO:0042803,GO:0044354,GO:0044877,GO:0045088,GO:0046322,GO:0046325,GO:0050768,GO:0051289,GO:0060100,GO:0070062,GO:0120162,GO:1900016,GO:1900077,GO:1905303,GO:1905451,GO:2000045,GO:2000178" "ruffle|phosphatidylserine binding|diet induced thermogenesis|protein binding|nucleus|endosome|plasma membrane|protein import into nucleus|cell cycle|signal transduction|transforming growth factor beta receptor signaling pathway|cold acclimation|endosome membrane|regulation of fibroblast migration|membrane|signaling|cytoplasmic vesicle|early endosome membrane|vesicle|early phagosome|ruffle membrane|adiponectin-activated signaling pathway|regulation of toll-like receptor 4 signaling pathway|phosphatidylinositol binding|cellular response to hepatocyte growth factor stimulus|early phagosome membrane|glucose homeostasis|identical protein binding|protein homodimerization activity|macropinosome|protein-containing complex binding|regulation of innate immune response|negative regulation of fatty acid oxidation|negative regulation of glucose import|negative regulation of neurogenesis|protein homotetramerization|positive regulation of phagocytosis, engulfment|extracellular exosome|positive regulation of cold-induced thermogenesis|negative regulation of cytokine production involved in inflammatory response|negative regulation of cellular response to insulin stimulus|positive regulation of macropinocytosis|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of G1/S transition of mitotic cell cycle|negative regulation of neural precursor cell proliferation" APRT 806.0438553 709.562268 902.5254427 1.271946781 0.347038309 0.167565339 1 40.67458015 50.87017105 353 adenine phosphoribosyltransferase "GO:0002055,GO:0003999,GO:0005515,GO:0005576,GO:0005654,GO:0005737,GO:0005829,GO:0006166,GO:0006168,GO:0007595,GO:0007625,GO:0016208,GO:0032869,GO:0034774,GO:0043101,GO:0043312,GO:0044209,GO:0070062" adenine binding|adenine phosphoribosyltransferase activity|protein binding|extracellular region|nucleoplasm|cytoplasm|cytosol|purine ribonucleoside salvage|adenine salvage|lactation|grooming behavior|AMP binding|cellular response to insulin stimulus|secretory granule lumen|purine-containing compound salvage|neutrophil degranulation|AMP salvage|extracellular exosome hsa00230 Purine metabolism APTX 814.84713 827.1290367 802.5652233 0.97030232 -0.043493773 0.867144764 1 5.042535583 4.810909861 54840 aprataxin "GO:0000012,GO:0000785,GO:0003682,GO:0003684,GO:0003690,GO:0003697,GO:0003725,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006266,GO:0006302,GO:0006974,GO:0008967,GO:0016311,GO:0030983,GO:0031647,GO:0033699,GO:0042542,GO:0046872,GO:0047485,GO:0051219,GO:0090305,GO:1990165" single strand break repair|chromatin|chromatin binding|damaged DNA binding|double-stranded DNA binding|single-stranded DNA binding|double-stranded RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|DNA ligation|double-strand break repair|cellular response to DNA damage stimulus|phosphoglycolate phosphatase activity|dephosphorylation|mismatched DNA binding|regulation of protein stability|DNA 5'-adenosine monophosphate hydrolase activity|response to hydrogen peroxide|metal ion binding|protein N-terminus binding|phosphoprotein binding|nucleic acid phosphodiester bond hydrolysis|single-strand break-containing DNA binding AQP1 2.962725795 2.080827765 3.844623824 1.847641543 0.88568489 0.829811711 1 0.043789414 0.079553269 358 aquaporin 1 (Colton blood group) "GO:0003091,GO:0003097,GO:0005223,GO:0005267,GO:0005372,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0005887,GO:0005903,GO:0006813,GO:0006833,GO:0006884,GO:0006972,GO:0008519,GO:0009925,GO:0009992,GO:0015079,GO:0015168,GO:0015250,GO:0015670,GO:0015696,GO:0015701,GO:0015793,GO:0016021,GO:0016323,GO:0016324,GO:0019725,GO:0019934,GO:0020005,GO:0021670,GO:0022857,GO:0030157,GO:0030184,GO:0030185,GO:0030950,GO:0031526,GO:0031965,GO:0033326,GO:0034644,GO:0035377,GO:0035378,GO:0035379,GO:0042383,GO:0042476,GO:0042802,GO:0043066,GO:0043154,GO:0045177,GO:0045766,GO:0046878,GO:0048146,GO:0050829,GO:0050891,GO:0070062,GO:0070301,GO:0071241,GO:0071260,GO:0071280,GO:0071288,GO:0071300,GO:0071320,GO:0071456,GO:0071472,GO:0071474,GO:0071549,GO:0071732,GO:0071805,GO:0072488,GO:0085018" renal water homeostasis|renal water transport|intracellular cGMP-activated cation channel activity|potassium channel activity|water transmembrane transporter activity|protein binding|nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|brush border|potassium ion transport|water transport|cell volume homeostasis|hyperosmotic response|ammonium transmembrane transporter activity|basal plasma membrane|cellular water homeostasis|potassium ion transmembrane transporter activity|glycerol transmembrane transporter activity|water channel activity|carbon dioxide transport|ammonium transport|bicarbonate transport|glycerol transport|integral component of membrane|basolateral plasma membrane|apical plasma membrane|cellular homeostasis|cGMP-mediated signaling|symbiont-containing vacuole membrane|lateral ventricle development|transmembrane transporter activity|pancreatic juice secretion|nitric oxide transmembrane transporter activity|nitric oxide transport|establishment or maintenance of actin cytoskeleton polarity|brush border membrane|nuclear membrane|cerebrospinal fluid secretion|cellular response to UV|transepithelial water transport|carbon dioxide transmembrane transport|carbon dioxide transmembrane transporter activity|sarcolemma|odontogenesis|identical protein binding|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|apical part of cell|positive regulation of angiogenesis|positive regulation of saliva secretion|positive regulation of fibroblast proliferation|defense response to Gram-negative bacterium|multicellular organismal water homeostasis|extracellular exosome|cellular response to hydrogen peroxide|cellular response to inorganic substance|cellular response to mechanical stimulus|cellular response to copper ion|cellular response to mercury ion|cellular response to retinoic acid|cellular response to cAMP|cellular response to hypoxia|cellular response to salt stress|cellular hyperosmotic response|cellular response to dexamethasone stimulus|cellular response to nitric oxide|potassium ion transmembrane transport|ammonium transmembrane transport|maintenance of symbiont-containing vacuole by host "hsa04924,hsa04964,hsa04976" Renin secretion|Proximal tubule bicarbonate reclamation|Bile secretion AQP11 33.42219197 44.73779695 22.10658699 0.494136692 -1.017017909 0.145354473 1 1.301130245 0.632177528 282679 aquaporin 11 "GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0005886,GO:0006612,GO:0006811,GO:0006833,GO:0008284,GO:0009986,GO:0009992,GO:0015250,GO:0015254,GO:0015267,GO:0015793,GO:0015840,GO:0016021,GO:0030104,GO:0030425,GO:0030659,GO:0032364,GO:0033577,GO:0042802,GO:0048388,GO:0048471,GO:0050680,GO:0051260,GO:0072014,GO:0080170,GO:1903573,GO:1904293" cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|plasma membrane|protein targeting to membrane|ion transport|water transport|positive regulation of cell population proliferation|cell surface|cellular water homeostasis|water channel activity|glycerol channel activity|channel activity|glycerol transport|urea transport|integral component of membrane|water homeostasis|dendrite|cytoplasmic vesicle membrane|oxygen homeostasis|protein glycosylation in endoplasmic reticulum|identical protein binding|endosomal lumen acidification|perinuclear region of cytoplasm|negative regulation of epithelial cell proliferation|protein homooligomerization|proximal tubule development|hydrogen peroxide transmembrane transport|negative regulation of response to endoplasmic reticulum stress|negative regulation of ERAD pathway AQP3 6.485287494 6.242483296 6.728091692 1.0777909 0.108077311 1 1 0.182547869 0.193456113 360 aquaporin 3 (Gill blood group) "GO:0002684,GO:0003091,GO:0005515,GO:0005654,GO:0005737,GO:0005886,GO:0005911,GO:0006833,GO:0015204,GO:0015250,GO:0015254,GO:0015793,GO:0016021,GO:0016323,GO:0032526,GO:0033280,GO:0042476,GO:0042802,GO:0045616,GO:0051592,GO:0070295,GO:0071456,GO:0071918,GO:0090650" positive regulation of immune system process|renal water homeostasis|protein binding|nucleoplasm|cytoplasm|plasma membrane|cell-cell junction|water transport|urea transmembrane transporter activity|water channel activity|glycerol channel activity|glycerol transport|integral component of membrane|basolateral plasma membrane|response to retinoic acid|response to vitamin D|odontogenesis|identical protein binding|regulation of keratinocyte differentiation|response to calcium ion|renal water absorption|cellular response to hypoxia|urea transmembrane transport|cellular response to oxygen-glucose deprivation hsa04962 Vasopressin-regulated water reabsorption AQR 1446.392104 1459.700677 1433.08353 0.981765339 -0.026549861 0.914523508 1 8.117280643 7.835909929 9716 aquarius intron-binding spliceosomal factor "GO:0000398,GO:0003723,GO:0003727,GO:0003729,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006283,GO:0016020,GO:0034458,GO:0071007,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|single-stranded RNA binding|mRNA binding|protein binding|ATP binding|nucleus|nucleoplasm|transcription-coupled nucleotide-excision repair|membrane|3'-5' RNA helicase activity|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome AR 222.8083155 247.6185041 197.9981269 0.799609576 -0.322632346 0.357655489 1 1.05474854 0.829274093 367 androgen receptor "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001085,GO:0001091,GO:0001225,GO:0001228,GO:0001701,GO:0003073,GO:0003382,GO:0003682,GO:0003700,GO:0004879,GO:0005102,GO:0005496,GO:0005497,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006357,GO:0006367,GO:0007165,GO:0007267,GO:0007283,GO:0007338,GO:0008013,GO:0008134,GO:0008270,GO:0008284,GO:0008285,GO:0008584,GO:0010628,GO:0016579,GO:0016607,GO:0019102,GO:0019899,GO:0030518,GO:0030520,GO:0030521,GO:0030522,GO:0032991,GO:0033148,GO:0033327,GO:0035264,GO:0042327,GO:0043410,GO:0043568,GO:0045597,GO:0045720,GO:0045726,GO:0045893,GO:0045944,GO:0045945,GO:0048638,GO:0048645,GO:0048808,GO:0050680,GO:0051092,GO:0051117,GO:0060520,GO:0060571,GO:0060599,GO:0060736,GO:0060740,GO:0060742,GO:0060748,GO:0060749,GO:0060769,GO:0070974,GO:0071383,GO:0071391,GO:0071394,GO:0072520,GO:1903076,GO:2001237" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|RNA polymerase II general transcription initiation factor binding|RNA polymerase II transcription coactivator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|in utero embryonic development|regulation of systemic arterial blood pressure|epithelial cell morphogenesis|chromatin binding|DNA-binding transcription factor activity|nuclear receptor activity|signaling receptor binding|steroid binding|androgen binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|signal transduction|cell-cell signaling|spermatogenesis|single fertilization|beta-catenin binding|transcription factor binding|zinc ion binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|male gonad development|positive regulation of gene expression|protein deubiquitination|nuclear speck|male somatic sex determination|enzyme binding|intracellular steroid hormone receptor signaling pathway|intracellular estrogen receptor signaling pathway|androgen receptor signaling pathway|intracellular receptor signaling pathway|protein-containing complex|positive regulation of intracellular estrogen receptor signaling pathway|Leydig cell differentiation|multicellular organism growth|positive regulation of phosphorylation|positive regulation of MAPK cascade|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of cell differentiation|negative regulation of integrin biosynthetic process|positive regulation of integrin biosynthetic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase III|regulation of developmental growth|animal organ formation|male genitalia morphogenesis|negative regulation of epithelial cell proliferation|positive regulation of NF-kappaB transcription factor activity|ATPase binding|activation of prostate induction by androgen receptor signaling pathway|morphogenesis of an epithelial fold|lateral sprouting involved in mammary gland duct morphogenesis|prostate gland growth|prostate gland epithelium morphogenesis|epithelial cell differentiation involved in prostate gland development|tertiary branching involved in mammary gland duct morphogenesis|mammary gland alveolus development|positive regulation of epithelial cell proliferation involved in prostate gland development|POU domain binding|cellular response to steroid hormone stimulus|cellular response to estrogen stimulus|cellular response to testosterone stimulus|seminiferous tubule development|regulation of protein localization to plasma membrane|negative regulation of extrinsic apoptotic signaling pathway" "hsa04114,hsa05200,hsa05215" Oocyte meiosis|Pathways in cancer|Prostate cancer Androgen_rcpt ARAF 1285.121693 1351.497634 1218.745752 0.901774241 -0.149161795 0.536981456 1 23.9465288 21.23301041 369 "A-Raf proto-oncogene, serine/threonine kinase" "GO:0000165,GO:0000186,GO:0004672,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005575,GO:0005739,GO:0005829,GO:0006464,GO:0006468,GO:0032006,GO:0032434,GO:0033138,GO:0043066,GO:0046872,GO:0106310,GO:0106311" MAPK cascade|activation of MAPKK activity|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|cellular_component|mitochondrion|cytosol|cellular protein modification process|protein phosphorylation|regulation of TOR signaling|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of peptidyl-serine phosphorylation|negative regulation of apoptotic process|metal ion binding|protein serine kinase activity|protein threonine kinase activity "hsa01521,hsa01522,hsa04010,hsa04012,hsa04068,hsa04270,hsa04650,hsa04720,hsa04726,hsa04730,hsa04810,hsa04910,hsa04914,hsa04928,hsa05010,hsa05022,hsa05034,hsa05160,hsa05161,hsa05200,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|FoxO signaling pathway|Vascular smooth muscle contraction|Natural killer cell mediated cytotoxicity|Long-term potentiation|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Parathyroid hormone synthesis, secretion and action|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|Hepatitis C|Hepatitis B|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer" ARAP1 2547.935467 2407.517724 2688.353209 1.116649394 0.159176279 0.50122466 1 22.75275299 24.98169865 116985 "ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1" "GO:0001921,GO:0005096,GO:0005515,GO:0005547,GO:0005654,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0007165,GO:0008360,GO:0030037,GO:0031410,GO:0031702,GO:0032580,GO:0043231,GO:0043547,GO:0045742,GO:0046872,GO:0051056,GO:0051270,GO:0051491,GO:0051497" "positive regulation of receptor recycling|GTPase activator activity|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleoplasm|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|signal transduction|regulation of cell shape|actin filament reorganization involved in cell cycle|cytoplasmic vesicle|type 1 angiotensin receptor binding|Golgi cisterna membrane|intracellular membrane-bounded organelle|positive regulation of GTPase activity|positive regulation of epidermal growth factor receptor signaling pathway|metal ion binding|regulation of small GTPase mediated signal transduction|regulation of cellular component movement|positive regulation of filopodium assembly|negative regulation of stress fiber assembly" hsa04144 Endocytosis ARAP2 547.8357013 554.5405994 541.1308032 0.975818189 -0.035315721 0.902003561 1 3.905874698 3.747644561 116984 "ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2" "GO:0005096,GO:0005547,GO:0005829,GO:0007165,GO:0043547,GO:0046872,GO:0051056" "GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|cytosol|signal transduction|positive regulation of GTPase activity|metal ion binding|regulation of small GTPase mediated signal transduction" hsa04144 Endocytosis ARAP3 1029.312013 1108.040785 950.5832405 0.857895534 -0.221126114 0.367768354 1 10.56343341 8.910676646 64411 "ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3" "GO:0001726,GO:0005096,GO:0005515,GO:0005547,GO:0005829,GO:0005856,GO:0005886,GO:0007010,GO:0007165,GO:0016192,GO:0030027,GO:0043325,GO:0043547,GO:0046872,GO:0051056" "ruffle|GTPase activator activity|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytosol|cytoskeleton|plasma membrane|cytoskeleton organization|signal transduction|vesicle-mediated transport|lamellipodium|phosphatidylinositol-3,4-bisphosphate binding|positive regulation of GTPase activity|metal ion binding|regulation of small GTPase mediated signal transduction" "hsa04015,hsa04024,hsa04144" Rap1 signaling pathway|cAMP signaling pathway|Endocytosis ARC 100.0092948 76.99062732 123.0279624 1.597960254 0.676231524 0.149199121 1 1.392829924 2.188443004 23237 activity regulated cytoskeleton associated protein "GO:0001669,GO:0003729,GO:0005515,GO:0005737,GO:0005886,GO:0005938,GO:0006897,GO:0007010,GO:0007492,GO:0007612,GO:0007616,GO:0009952,GO:0015629,GO:0016477,GO:0022604,GO:0031901,GO:0043025,GO:0043197,GO:0045121,GO:0048168,GO:0050804,GO:0051028,GO:0051260,GO:0060291,GO:0060997,GO:0061001,GO:0071598,GO:0098839,GO:0098845,GO:0098978,GO:0099149,GO:0110077,GO:1900271,GO:1900452,GO:1903561,GO:2000969" acrosomal vesicle|mRNA binding|protein binding|cytoplasm|plasma membrane|cell cortex|endocytosis|cytoskeleton organization|endoderm development|learning|long-term memory|anterior/posterior pattern specification|actin cytoskeleton|cell migration|regulation of cell morphogenesis|early endosome membrane|neuronal cell body|dendritic spine|membrane raft|regulation of neuronal synaptic plasticity|modulation of chemical synaptic transmission|mRNA transport|protein homooligomerization|long-term synaptic potentiation|dendritic spine morphogenesis|regulation of dendritic spine morphogenesis|neuronal ribonucleoprotein granule|postsynaptic density membrane|postsynaptic endosome|glutamatergic synapse|regulation of postsynaptic neurotransmitter receptor internalization|vesicle-mediated intercellular transport|regulation of long-term synaptic potentiation|regulation of long-term synaptic depression|extracellular vesicle|positive regulation of AMPA receptor activity hsa05031 Amphetamine addiction ARCN1 7247.854076 6517.152561 7978.555591 1.2242395 0.291885822 0.233597047 1 86.80021317 104.4860612 372 archain 1 "GO:0000139,GO:0003723,GO:0005515,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0016020,GO:0030126,GO:0030133,GO:0051645" "Golgi membrane|RNA binding|protein binding|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|membrane|COPI vesicle coat|transport vesicle|Golgi localization" AREG 299.6114732 270.5076095 328.7153369 1.215179631 0.281169592 0.374180197 1 11.69894161 13.97842475 374 amphiregulin "GO:0000139,GO:0000165,GO:0005125,GO:0005154,GO:0005515,GO:0005576,GO:0005615,GO:0005789,GO:0006888,GO:0007165,GO:0007173,GO:0007186,GO:0007267,GO:0008083,GO:0008284,GO:0009986,GO:0010838,GO:0012507,GO:0016021,GO:0030665,GO:0033116,GO:0042059,GO:0045741,GO:0048208,GO:0051897,GO:0061024" Golgi membrane|MAPK cascade|cytokine activity|epidermal growth factor receptor binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|signal transduction|epidermal growth factor receptor signaling pathway|G protein-coupled receptor signaling pathway|cell-cell signaling|growth factor activity|positive regulation of cell population proliferation|cell surface|positive regulation of keratinocyte proliferation|ER to Golgi transport vesicle membrane|integral component of membrane|clathrin-coated vesicle membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of epidermal growth factor-activated receptor activity|COPII vesicle coating|positive regulation of protein kinase B signaling|membrane organization "hsa04010,hsa04012,hsa04151,hsa04390,hsa05210" MAPK signaling pathway|ErbB signaling pathway|PI3K-Akt signaling pathway|Hippo signaling pathway|Colorectal cancer AREL1 1653.747697 1692.753387 1614.742006 0.953914503 -0.068068128 0.776569751 1 16.38359396 15.36702531 9870 apoptosis resistant E3 ubiquitin protein ligase 1 "GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0006511,GO:0006915,GO:0016567,GO:0043066,GO:0043161,GO:0045732,GO:0050727,GO:0061630" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|apoptotic process|protein ubiquitination|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of protein catabolic process|regulation of inflammatory response|ubiquitin protein ligase activity ARF1 9517.891554 8934.03401 10101.7491 1.130704124 0.177221463 0.47879732 1 229.1172393 254.7287254 375 ADP ribosylation factor 1 "GO:0000139,GO:0000287,GO:0002090,GO:0003723,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005770,GO:0005778,GO:0005802,GO:0005829,GO:0005886,GO:0005925,GO:0006661,GO:0006878,GO:0006886,GO:0007015,GO:0014069,GO:0016192,GO:0019003,GO:0019886,GO:0019904,GO:0030017,GO:0030137,GO:0031252,GO:0032991,GO:0034315,GO:0034379,GO:0035722,GO:0043005,GO:0045807,GO:0045956,GO:0048471,GO:0050690,GO:0050714,GO:0050790,GO:0055108,GO:0060292,GO:0060999,GO:0070062,GO:0070142,GO:0097061,GO:0097212,GO:0098586,GO:0098974,GO:0098978,GO:1902307,GO:1902824,GO:1902953,GO:1903725,GO:1990386,GO:1990583" Golgi membrane|magnesium ion binding|regulation of receptor internalization|RNA binding|GTPase activity|protein binding|GTP binding|cytoplasm|late endosome|peroxisomal membrane|trans-Golgi network|cytosol|plasma membrane|focal adhesion|phosphatidylinositol biosynthetic process|cellular copper ion homeostasis|intracellular protein transport|actin filament organization|postsynaptic density|vesicle-mediated transport|GDP binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein domain specific binding|sarcomere|COPI-coated vesicle|cell leading edge|protein-containing complex|regulation of Arp2/3 complex-mediated actin nucleation|very-low-density lipoprotein particle assembly|interleukin-12-mediated signaling pathway|neuron projection|positive regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|perinuclear region of cytoplasm|regulation of defense response to virus by virus|positive regulation of protein secretion|regulation of catalytic activity|Golgi to transport vesicle transport|long-term synaptic depression|positive regulation of dendritic spine development|extracellular exosome|synaptic vesicle budding|dendritic spine organization|lysosomal membrane organization|cellular response to virus|postsynaptic actin cytoskeleton organization|glutamatergic synapse|positive regulation of sodium ion transmembrane transport|positive regulation of late endosome to lysosome transport|positive regulation of ER to Golgi vesicle-mediated transport|regulation of phospholipid metabolic process|mitotic cleavage furrow ingression|phospholipase D activator activity "hsa04072,hsa04144,hsa05110,hsa05130,hsa05131,hsa05132,hsa05134" Phospholipase D signaling pathway|Endocytosis|Vibrio cholerae infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Legionellosis ARF3 5613.414516 5507.951095 5718.877938 1.038294974 0.054216364 0.82282107 1 51.73340844 52.81569791 377 ADP ribosylation factor 3 "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005886,GO:0006661,GO:0006886,GO:0006890,GO:0016192,GO:0048471,GO:0070062" "Golgi membrane|GTPase activity|protein binding|GTP binding|cytoplasm|plasma membrane|phosphatidylinositol biosynthetic process|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|vesicle-mediated transport|perinuclear region of cytoplasm|extracellular exosome" hsa04144 Endocytosis ARF4 5897.007056 5181.261136 6612.752977 1.276282512 0.351947713 0.145975767 1 173.2546266 217.4216753 378 ADP ribosylation factor 4 "GO:0003924,GO:0005154,GO:0005515,GO:0005525,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0006471,GO:0006886,GO:0006888,GO:0006890,GO:0007173,GO:0007420,GO:0007612,GO:0016020,GO:0016192,GO:0016477,GO:0031584,GO:0032587,GO:0043066,GO:0043197,GO:0045176,GO:0045197,GO:0045944,GO:0048678,GO:0060996,GO:0061512,GO:0070062,GO:0098978,GO:0099175,GO:2000377" "GTPase activity|epidermal growth factor receptor binding|protein binding|GTP binding|cytoplasm|Golgi apparatus|cytosol|plasma membrane|protein ADP-ribosylation|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|epidermal growth factor receptor signaling pathway|brain development|learning|membrane|vesicle-mediated transport|cell migration|activation of phospholipase D activity|ruffle membrane|negative regulation of apoptotic process|dendritic spine|apical protein localization|establishment or maintenance of epithelial cell apical/basal polarity|positive regulation of transcription by RNA polymerase II|response to axon injury|dendritic spine development|protein localization to cilium|extracellular exosome|glutamatergic synapse|regulation of postsynapse organization|regulation of reactive oxygen species metabolic process" hsa04144 Endocytosis ARF5 1557.217533 1429.528675 1684.906391 1.178644696 0.237128882 0.319881489 1 73.92569575 85.67409104 381 ADP ribosylation factor 5 "GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005794,GO:0005886,GO:0006886,GO:0006890,GO:0016192,GO:0048471,GO:0070062" "GTPase activity|protein binding|GTP binding|cytoplasm|Golgi apparatus|plasma membrane|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|vesicle-mediated transport|perinuclear region of cytoplasm|extracellular exosome" hsa04144 Endocytosis ARF6 3405.989955 3246.091314 3565.888597 1.098517648 0.135558048 0.568139421 1 44.7065619 48.28914205 382 ADP ribosylation factor 6 "GO:0001726,GO:0001889,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005768,GO:0005794,GO:0005829,GO:0005886,GO:0005925,GO:0005938,GO:0006886,GO:0007049,GO:0007155,GO:0007399,GO:0016020,GO:0016192,GO:0019003,GO:0030139,GO:0030154,GO:0030838,GO:0030866,GO:0031527,GO:0031901,GO:0031996,GO:0032154,GO:0032456,GO:0033028,GO:0034394,GO:0035020,GO:0036010,GO:0047485,GO:0048261,GO:0048488,GO:0050714,GO:0051301,GO:0051489,GO:0051549,GO:0055038,GO:0060998,GO:0070062,GO:0090162,GO:0090543,GO:0097178,GO:0097284,GO:0098793,GO:0098978,GO:0099562,GO:0120183,GO:1903078,GO:1905606,GO:1990090,GO:2000009,GO:2000171" ruffle|liver development|GTPase activity|protein binding|GTP binding|cytoplasm|endosome|Golgi apparatus|cytosol|plasma membrane|focal adhesion|cell cortex|intracellular protein transport|cell cycle|cell adhesion|nervous system development|membrane|vesicle-mediated transport|GDP binding|endocytic vesicle|cell differentiation|positive regulation of actin filament polymerization|cortical actin cytoskeleton organization|filopodium membrane|early endosome membrane|thioesterase binding|cleavage furrow|endocytic recycling|myeloid cell apoptotic process|protein localization to cell surface|regulation of Rac protein signal transduction|protein localization to endosome|protein N-terminus binding|negative regulation of receptor-mediated endocytosis|synaptic vesicle endocytosis|positive regulation of protein secretion|cell division|regulation of filopodium assembly|positive regulation of keratinocyte migration|recycling endosome membrane|regulation of dendritic spine development|extracellular exosome|establishment of epithelial cell polarity|Flemming body|ruffle assembly|hepatocyte apoptotic process|presynapse|glutamatergic synapse|maintenance of postsynaptic density structure|positive regulation of focal adhesion disassembly|positive regulation of protein localization to plasma membrane|regulation of presynapse assembly|cellular response to nerve growth factor stimulus|negative regulation of protein localization to cell surface|negative regulation of dendrite development "hsa04014,hsa04072,hsa04144,hsa04666,hsa05130,hsa05131,hsa05132,hsa05135" Ras signaling pathway|Phospholipase D signaling pathway|Endocytosis|Fc gamma R-mediated phagocytosis|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ARFGAP1 2388.657179 2225.445295 2551.869063 1.146677957 0.197460269 0.403796923 1 31.91828143 35.98753846 55738 ADP ribosylation factor GTPase activating protein 1 "GO:0000139,GO:0005096,GO:0005515,GO:0005829,GO:0006888,GO:0006890,GO:0015031,GO:0030100,GO:0032012,GO:0036498,GO:0043547,GO:0045202,GO:0046872" "Golgi membrane|GTPase activator activity|protein binding|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|protein transport|regulation of endocytosis|regulation of ARF protein signal transduction|IRE1-mediated unfolded protein response|positive regulation of GTPase activity|synapse|metal ion binding" hsa04144 Endocytosis ARFGAP2 1091.73746 1131.970304 1051.504616 0.928915372 -0.106380928 0.665101884 1 21.13017652 19.29969534 84364 ADP ribosylation factor GTPase activating protein 2 "GO:0000139,GO:0005096,GO:0005794,GO:0005829,GO:0005886,GO:0006888,GO:0006890,GO:0015031,GO:0043547,GO:0046872,GO:0048205" "Golgi membrane|GTPase activator activity|Golgi apparatus|cytosol|plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|protein transport|positive regulation of GTPase activity|metal ion binding|COPI coating of Golgi vesicle" hsa04144 Endocytosis ARFGAP3 1571.942457 1361.901772 1781.983142 1.308452033 0.387861037 0.103465014 1 26.43950328 34.01592432 26286 ADP ribosylation factor GTPase activating protein 3 "GO:0000139,GO:0005096,GO:0005515,GO:0005794,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0009306,GO:0016020,GO:0016192,GO:0043547,GO:0046872,GO:0048205" "Golgi membrane|GTPase activator activity|protein binding|Golgi apparatus|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|protein secretion|membrane|vesicle-mediated transport|positive regulation of GTPase activity|metal ion binding|COPI coating of Golgi vesicle" hsa04144 Endocytosis ARFGEF1 3027.157343 2990.149499 3064.165188 1.024753173 0.035276458 0.882874256 1 18.78060293 18.92343536 10565 ADP ribosylation factor guanine nucleotide exchange factor 1 "GO:0000139,GO:0005085,GO:0005096,GO:0005515,GO:0005654,GO:0005730,GO:0005794,GO:0005802,GO:0005829,GO:0006887,GO:0007030,GO:0010256,GO:0015031,GO:0016363,GO:0017022,GO:0030532,GO:0030837,GO:0031175,GO:0032012,GO:0034237,GO:0034260,GO:0043547,GO:0048471,GO:0051897,GO:0090284,GO:0090303,GO:2000114" Golgi membrane|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|nucleoplasm|nucleolus|Golgi apparatus|trans-Golgi network|cytosol|exocytosis|Golgi organization|endomembrane system organization|protein transport|nuclear matrix|myosin binding|small nuclear ribonucleoprotein complex|negative regulation of actin filament polymerization|neuron projection development|regulation of ARF protein signal transduction|protein kinase A regulatory subunit binding|negative regulation of GTPase activity|positive regulation of GTPase activity|perinuclear region of cytoplasm|positive regulation of protein kinase B signaling|positive regulation of protein glycosylation in Golgi|positive regulation of wound healing|regulation of establishment of cell polarity hsa04144 Endocytosis ARFGEF2 2709.282064 3022.402329 2396.161798 0.792800408 -0.334970391 0.156690298 1 19.33357993 15.07118225 10564 ADP ribosylation factor guanine nucleotide exchange factor 2 "GO:0000139,GO:0001881,GO:0005085,GO:0005515,GO:0005794,GO:0005802,GO:0005815,GO:0005829,GO:0005879,GO:0006887,GO:0006893,GO:0007032,GO:0010256,GO:0015031,GO:0016020,GO:0017022,GO:0031410,GO:0032012,GO:0032279,GO:0032280,GO:0032760,GO:0034237,GO:0035556,GO:0043197,GO:0043231,GO:0048471,GO:0050790,GO:0050811,GO:0055037" Golgi membrane|receptor recycling|guanyl-nucleotide exchange factor activity|protein binding|Golgi apparatus|trans-Golgi network|microtubule organizing center|cytosol|axonemal microtubule|exocytosis|Golgi to plasma membrane transport|endosome organization|endomembrane system organization|protein transport|membrane|myosin binding|cytoplasmic vesicle|regulation of ARF protein signal transduction|asymmetric synapse|symmetric synapse|positive regulation of tumor necrosis factor production|protein kinase A regulatory subunit binding|intracellular signal transduction|dendritic spine|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|regulation of catalytic activity|GABA receptor binding|recycling endosome hsa04144 Endocytosis ARFGEF3 413.1505646 462.9841778 363.3169514 0.784728656 -0.349734212 0.222734877 1 1.662871972 1.283067498 57221 ARFGEF family member 3 "GO:0005085,GO:0010923,GO:0016021,GO:0030036,GO:0030658,GO:0032012" guanyl-nucleotide exchange factor activity|negative regulation of phosphatase activity|integral component of membrane|actin cytoskeleton organization|transport vesicle membrane|regulation of ARF protein signal transduction ARFIP1 769.7482563 639.8545378 899.6419748 1.40601015 0.491607009 0.051931384 1 5.218193869 7.214061572 27236 ADP ribosylation factor interacting protein 1 "GO:0000139,GO:0005515,GO:0005543,GO:0005829,GO:0006886,GO:0019904,GO:0032588,GO:0034315,GO:0050708,GO:0070273,GO:1905280" "Golgi membrane|protein binding|phospholipid binding|cytosol|intracellular protein transport|protein domain specific binding|trans-Golgi network membrane|regulation of Arp2/3 complex-mediated actin nucleation|regulation of protein secretion|phosphatidylinositol-4-phosphate binding|negative regulation of retrograde transport, endosome to Golgi" ARFIP2 1192.762631 1172.546446 1212.978816 1.034482532 0.048909285 0.843157705 1 33.60722275 34.18432155 23647 ADP ribosylation factor interacting protein 2 "GO:0001726,GO:0005515,GO:0005525,GO:0005543,GO:0005737,GO:0005829,GO:0005886,GO:0005938,GO:0006886,GO:0006914,GO:0007264,GO:0019904,GO:0030032,GO:0030036,GO:0030742,GO:0031267,GO:0031529,GO:0032588,GO:0034315,GO:0042802,GO:0045296,GO:0070273,GO:0140090" ruffle|protein binding|GTP binding|phospholipid binding|cytoplasm|cytosol|plasma membrane|cell cortex|intracellular protein transport|autophagy|small GTPase mediated signal transduction|protein domain specific binding|lamellipodium assembly|actin cytoskeleton organization|GTP-dependent protein binding|small GTPase binding|ruffle organization|trans-Golgi network membrane|regulation of Arp2/3 complex-mediated actin nucleation|identical protein binding|cadherin binding|phosphatidylinositol-4-phosphate binding|membrane curvature sensor activity ARFRP1 833.1883511 829.2098645 837.1668377 1.00959585 0.013777885 0.961406671 1 17.03364374 16.90932591 10139 ADP ribosylation factor related protein 1 "GO:0003924,GO:0005515,GO:0005525,GO:0005794,GO:0005802,GO:0005829,GO:0006886,GO:0007165,GO:0007369,GO:0016020,GO:0032588,GO:0033365,GO:0034067,GO:0042147,GO:0043001" "GTPase activity|protein binding|GTP binding|Golgi apparatus|trans-Golgi network|cytosol|intracellular protein transport|signal transduction|gastrulation|membrane|trans-Golgi network membrane|protein localization to organelle|protein localization to Golgi apparatus|retrograde transport, endosome to Golgi|Golgi to plasma membrane protein transport" ARG2 168.4243604 144.6175297 192.2311912 1.32923852 0.410600007 0.292386199 1 4.038708406 5.278573769 384 arginase 2 "GO:0000050,GO:0001657,GO:0002250,GO:0002829,GO:0004053,GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0006809,GO:0006941,GO:0019547,GO:0030145,GO:0032651,GO:0032696,GO:0032700,GO:0032720,GO:0045087,GO:0071641,GO:0071644,GO:0071650,GO:1900425,GO:1903426,GO:1905403,GO:2000562,GO:2000774" "urea cycle|ureteric bud development|adaptive immune response|negative regulation of type 2 immune response|arginase activity|protein binding|cytoplasm|mitochondrion|mitochondrial matrix|nitric oxide biosynthetic process|striated muscle contraction|arginine catabolic process to ornithine|manganese ion binding|regulation of interleukin-1 beta production|negative regulation of interleukin-13 production|negative regulation of interleukin-17 production|negative regulation of tumor necrosis factor production|innate immune response|negative regulation of macrophage inflammatory protein 1 alpha production|negative regulation of chemokine (C-C motif) ligand 4 production|negative regulation of chemokine (C-C motif) ligand 5 production|negative regulation of defense response to bacterium|regulation of reactive oxygen species biosynthetic process|negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process|negative regulation of CD4-positive, alpha-beta T cell proliferation|positive regulation of cellular senescence" "hsa00220,hsa00330,hsa05146" Arginine biosynthesis|Arginine and proline metabolism|Amoebiasis ARGLU1 2099.841104 1998.635069 2201.047139 1.101275152 0.139174969 0.556993627 1 31.71676487 34.34439747 55082 arginine and glutamate rich 1 "GO:0005515,GO:0005654,GO:0005739,GO:0005829,GO:0045296" protein binding|nucleoplasm|mitochondrion|cytosol|cadherin binding ARHGAP1 1362.96465 1477.387713 1248.541587 0.845100833 -0.242804609 0.311744559 1 18.68818842 15.52912237 392 Rho GTPase activating protein 1 "GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0007264,GO:0007266,GO:0010008,GO:0016197,GO:0017124,GO:0031267,GO:0033572,GO:0043547,GO:0045296,GO:0048471,GO:0051056,GO:0070062,GO:0097443,GO:2001136" GTPase activator activity|protein binding|cytoplasm|cytosol|small GTPase mediated signal transduction|Rho protein signal transduction|endosome membrane|endosomal transport|SH3 domain binding|small GTPase binding|transferrin transport|positive regulation of GTPase activity|cadherin binding|perinuclear region of cytoplasm|regulation of small GTPase mediated signal transduction|extracellular exosome|sorting endosome|negative regulation of endocytic recycling ARHGAP10 682.3623222 641.9353656 722.7892789 1.125953356 0.171147063 0.508099595 1 9.889985749 10.94932241 79658 Rho GTPase activating protein 10 "GO:0005096,GO:0005515,GO:0005829,GO:0005886,GO:0007010,GO:0007165,GO:0043066,GO:0043547,GO:0048471,GO:0051056" GTPase activator activity|protein binding|cytosol|plasma membrane|cytoskeleton organization|signal transduction|negative regulation of apoptotic process|positive regulation of GTPase activity|perinuclear region of cytoplasm|regulation of small GTPase mediated signal transduction hsa05100 Bacterial invasion of epithelial cells ARHGAP11A 1269.118581 1410.801225 1127.435936 0.799145845 -0.323469275 0.179640418 1 12.04284524 9.462945294 9824 Rho GTPase activating protein 11A "GO:0005096,GO:0005829,GO:0007165,GO:0043547,GO:0051056" GTPase activator activity|cytosol|signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction ARHGAP11B 138.1032884 156.0620824 120.1444945 0.769850643 -0.377349516 0.370148633 1 5.321882752 4.028496195 89839 Rho GTPase activating protein 11B "GO:0005096,GO:0005829,GO:0007165,GO:0021987,GO:0043547,GO:0051056" GTPase activator activity|cytosol|signal transduction|cerebral cortex development|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction ARHGAP12 1351.599355 1456.579436 1246.619275 0.855853958 -0.224563457 0.34988019 1 15.25112172 12.83431308 94134 Rho GTPase activating protein 12 "GO:0001891,GO:0002011,GO:0005096,GO:0005737,GO:0005829,GO:0006911,GO:0007015,GO:0007165,GO:0043087,GO:0043547,GO:0051056,GO:0051058" "phagocytic cup|morphogenesis of an epithelial sheet|GTPase activator activity|cytoplasm|cytosol|phagocytosis, engulfment|actin filament organization|signal transduction|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|negative regulation of small GTPase mediated signal transduction" ARHGAP17 1170.373611 1177.748515 1162.998707 0.987476267 -0.018182021 0.944020506 1 15.50808627 15.0576103 55114 Rho GTPase activating protein 17 "GO:0005096,GO:0005515,GO:0005622,GO:0005654,GO:0005829,GO:0005886,GO:0005923,GO:0007015,GO:0007165,GO:0017124,GO:0017156,GO:0032956,GO:0035020,GO:0043547,GO:0051056" GTPase activator activity|protein binding|intracellular anatomical structure|nucleoplasm|cytosol|plasma membrane|bicellular tight junction|actin filament organization|signal transduction|SH3 domain binding|calcium-ion regulated exocytosis|regulation of actin cytoskeleton organization|regulation of Rac protein signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction hsa04530 Tight junction ARHGAP18 2517.624456 2393.992344 2641.256567 1.103285302 0.141805911 0.549201546 1 26.95421338 29.24055917 93663 Rho GTPase activating protein 18 "GO:0001726,GO:0005096,GO:0005737,GO:0005829,GO:0005881,GO:0005886,GO:0007264,GO:0008360,GO:0016607,GO:0030833,GO:0032956,GO:0043547,GO:0045296,GO:0051056,GO:2000145" ruffle|GTPase activator activity|cytoplasm|cytosol|cytoplasmic microtubule|plasma membrane|small GTPase mediated signal transduction|regulation of cell shape|nuclear speck|regulation of actin filament polymerization|regulation of actin cytoskeleton organization|positive regulation of GTPase activity|cadherin binding|regulation of small GTPase mediated signal transduction|regulation of cell motility ARHGAP19 1169.838313 1214.163001 1125.513624 0.926987253 -0.109378595 0.654178096 1 11.80285024 10.75800737 84986 Rho GTPase activating protein 19 "GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0043231,GO:0043547,GO:0051056" GTPase activator activity|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|signal transduction|intracellular membrane-bounded organelle|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction ARHGAP21 2223.114443 2383.588205 2062.640682 0.865351103 -0.208642492 0.377683275 1 11.9905478 10.20240489 57584 Rho GTPase activating protein 21 "GO:0000139,GO:0005096,GO:0005515,GO:0005794,GO:0005829,GO:0005886,GO:0007030,GO:0007165,GO:0015629,GO:0030054,GO:0030659,GO:0043547,GO:0051056,GO:0051645,GO:0051683,GO:0051684,GO:0072384" Golgi membrane|GTPase activator activity|protein binding|Golgi apparatus|cytosol|plasma membrane|Golgi organization|signal transduction|actin cytoskeleton|cell junction|cytoplasmic vesicle membrane|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|Golgi localization|establishment of Golgi localization|maintenance of Golgi location|organelle transport along microtubule ARHGAP22 1097.227607 1023.767261 1170.687954 1.143509858 0.193468803 0.428564266 1 6.527667514 7.339544652 58504 Rho GTPase activating protein 22 "GO:0001525,GO:0005096,GO:0005515,GO:0005634,GO:0005829,GO:0005925,GO:0007165,GO:0030154,GO:0051056,GO:0090630,GO:0098978,GO:0099175" angiogenesis|GTPase activator activity|protein binding|nucleus|cytosol|focal adhesion|signal transduction|cell differentiation|regulation of small GTPase mediated signal transduction|activation of GTPase activity|glutamatergic synapse|regulation of postsynapse organization ARHGAP23 2047.046109 2126.605976 1967.486242 0.925176673 -0.112199204 0.636336656 1 17.34572099 15.77931729 57636 Rho GTPase activating protein 23 "GO:0005096,GO:0005829,GO:0007165,GO:0043547,GO:0051056,GO:0070062" GTPase activator activity|cytosol|signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|extracellular exosome ARHGAP24 290.4509235 244.4972624 336.4045846 1.375903277 0.460379055 0.147686926 1 0.809100857 1.094615882 83478 Rho GTPase activating protein 24 "GO:0001525,GO:0005096,GO:0005515,GO:0005829,GO:0005856,GO:0005912,GO:0005925,GO:0007165,GO:0030154,GO:0035021,GO:0035313,GO:0042995,GO:0051056,GO:0090630,GO:1900028" "angiogenesis|GTPase activator activity|protein binding|cytosol|cytoskeleton|adherens junction|focal adhesion|signal transduction|cell differentiation|negative regulation of Rac protein signal transduction|wound healing, spreading of epidermal cells|cell projection|regulation of small GTPase mediated signal transduction|activation of GTPase activity|negative regulation of ruffle assembly" ARHGAP26 308.2222479 269.4671956 346.9773001 1.28764208 0.364731629 0.243332641 1 1.283671246 1.625249917 23092 Rho GTPase activating protein 26 "GO:0005096,GO:0005515,GO:0005543,GO:0005575,GO:0005829,GO:0005856,GO:0005925,GO:0007165,GO:0007399,GO:0030036,GO:0043547,GO:0051056" GTPase activator activity|protein binding|phospholipid binding|cellular_component|cytosol|cytoskeleton|focal adhesion|signal transduction|nervous system development|actin cytoskeleton organization|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction ARHGAP27 262.3937328 302.7604398 222.0270258 0.733342262 -0.447441411 0.17456391 1 2.707854571 1.952554787 201176 Rho GTPase activating protein 27 "GO:0005096,GO:0005737,GO:0006898,GO:0007165,GO:0016020,GO:0017124,GO:0043087,GO:0043547" GTPase activator activity|cytoplasm|receptor-mediated endocytosis|signal transduction|membrane|SH3 domain binding|regulation of GTPase activity|positive regulation of GTPase activity ARHGAP29 14848.19472 14667.75492 15028.63453 1.024603602 0.035065869 0.893838451 1 85.1693093 85.80452319 9411 Rho GTPase activating protein 29 "GO:0005096,GO:0005737,GO:0005829,GO:0007266,GO:0030165,GO:0032991,GO:0046872,GO:0051056,GO:0090630" GTPase activator activity|cytoplasm|cytosol|Rho protein signal transduction|PDZ domain binding|protein-containing complex|metal ion binding|regulation of small GTPase mediated signal transduction|activation of GTPase activity ARHGAP31 463.2740989 504.6007331 421.9474647 0.836200657 -0.258078917 0.355168787 1 2.864547783 2.355254023 57514 Rho GTPase activating protein 31 "GO:0005096,GO:0005829,GO:0005925,GO:0007264,GO:0017124,GO:0030027,GO:0043547,GO:0051056" GTPase activator activity|cytosol|focal adhesion|small GTPase mediated signal transduction|SH3 domain binding|lamellipodium|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction ARHGAP32 450.5066991 484.8328693 416.1805289 0.858399987 -0.22027804 0.434175657 1 1.926486423 1.62602356 9743 Rho GTPase activating protein 32 "GO:0000139,GO:0001650,GO:0005096,GO:0005515,GO:0005654,GO:0005789,GO:0005794,GO:0005829,GO:0005938,GO:0007264,GO:0010008,GO:0014069,GO:0015629,GO:0043197,GO:0043547,GO:0051056,GO:1901981" Golgi membrane|fibrillar center|GTPase activator activity|protein binding|nucleoplasm|endoplasmic reticulum membrane|Golgi apparatus|cytosol|cell cortex|small GTPase mediated signal transduction|endosome membrane|postsynaptic density|actin cytoskeleton|dendritic spine|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|phosphatidylinositol phosphate binding ARHGAP33 153.4025258 153.9812546 152.823797 0.992483126 -0.01088552 0.996987441 1 1.177657861 1.149247178 115703 Rho GTPase activating protein 33 "GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007264,GO:0009636,GO:0015031,GO:0019901,GO:0032991,GO:0035091,GO:0043197,GO:0043547,GO:0051056,GO:0061001" GTPase activator activity|protein binding|cytoplasm|cytosol|plasma membrane|small GTPase mediated signal transduction|response to toxic substance|protein transport|protein kinase binding|protein-containing complex|phosphatidylinositol binding|dendritic spine|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|regulation of dendritic spine morphogenesis ARHGAP35 2332.229568 2523.003665 2141.45547 0.848772239 -0.236550625 0.31703917 1 13.97779181 11.66543432 2909 Rho GTPase activating protein 35 "GO:0001843,GO:0003677,GO:0003924,GO:0005096,GO:0005525,GO:0005543,GO:0005634,GO:0005829,GO:0005886,GO:0007165,GO:0007411,GO:0007413,GO:0008064,GO:0008360,GO:0010976,GO:0015629,GO:0016477,GO:0021955,GO:0030879,GO:0030900,GO:0030950,GO:0031668,GO:0032956,GO:0035024,GO:0036064,GO:0043010,GO:0043116,GO:0043547,GO:0044319,GO:0045724,GO:0050770,GO:0051056,GO:0097485" "neural tube closure|DNA binding|GTPase activity|GTPase activator activity|GTP binding|phospholipid binding|nucleus|cytosol|plasma membrane|signal transduction|axon guidance|axonal fasciculation|regulation of actin polymerization or depolymerization|regulation of cell shape|positive regulation of neuron projection development|actin cytoskeleton|cell migration|central nervous system neuron axonogenesis|mammary gland development|forebrain development|establishment or maintenance of actin cytoskeleton polarity|cellular response to extracellular stimulus|regulation of actin cytoskeleton organization|negative regulation of Rho protein signal transduction|ciliary basal body|camera-type eye development|negative regulation of vascular permeability|positive regulation of GTPase activity|wound healing, spreading of cells|positive regulation of cilium assembly|regulation of axonogenesis|regulation of small GTPase mediated signal transduction|neuron projection guidance" "hsa04510,hsa04611,hsa04670,hsa04810" Focal adhesion|Platelet activation|Leukocyte transendothelial migration|Regulation of actin cytoskeleton ARHGAP39 294.8799209 285.0734038 304.686438 1.068799944 0.095991837 0.77039611 1 2.184955281 2.296202332 80728 Rho GTPase activating protein 39 "GO:0005096,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0007165,GO:0043547,GO:0051056,GO:0098978,GO:0099173" GTPase activator activity|nucleus|cytoplasm|cytosol|cytoskeleton|signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|glutamatergic synapse|postsynapse organization ARHGAP4 5.04355356 6.242483296 3.844623824 0.615880514 -0.699277611 0.760739355 1 0.098740326 0.059794632 393 Rho GTPase activating protein 4 "GO:0005096,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0005874,GO:0007010,GO:0007266,GO:0010764,GO:0030336,GO:0030426,GO:0030517,GO:0043547,GO:0051056" GTPase activator activity|protein binding|cytoplasm|Golgi apparatus|cytosol|microtubule|cytoskeleton organization|Rho protein signal transduction|negative regulation of fibroblast migration|negative regulation of cell migration|growth cone|negative regulation of axon extension|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction ARHGAP40 4.562975582 6.242483296 2.883467868 0.461910386 -1.11431511 0.584550016 1 0.112398738 0.051049365 343578 Rho GTPase activating protein 40 "GO:0005096,GO:0005737,GO:0005829,GO:0007165,GO:0030833,GO:0043547,GO:0051056" GTPase activator activity|cytoplasm|cytosol|signal transduction|regulation of actin filament polymerization|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction ARHGAP42 270.5044222 250.7397457 290.2690987 1.157650926 0.211200293 0.522489792 1 1.104267981 1.256965279 143872 Rho GTPase activating protein 42 "GO:0003085,GO:0005096,GO:0005575,GO:0007165,GO:0035024,GO:0090630,GO:1904694" negative regulation of systemic arterial blood pressure|GTPase activator activity|cellular_component|signal transduction|negative regulation of Rho protein signal transduction|activation of GTPase activity|negative regulation of vascular associated smooth muscle contraction ARHGAP44 4.92466667 3.121241648 6.728091692 2.155581801 1.108077311 0.568402303 1 0.038532253 0.081669537 9912 Rho GTPase activating protein 44 "GO:0005096,GO:0005515,GO:0005543,GO:0005622,GO:0005829,GO:0006887,GO:0007165,GO:0014069,GO:0030425,GO:0031256,GO:0032956,GO:0035020,GO:0035021,GO:0043087,GO:0043197,GO:0043547,GO:0048786,GO:0051056,GO:0051490,GO:0055037,GO:0061001,GO:0098886,GO:0098887,GO:0098978,GO:0099152" "GTPase activator activity|protein binding|phospholipid binding|intracellular anatomical structure|cytosol|exocytosis|signal transduction|postsynaptic density|dendrite|leading edge membrane|regulation of actin cytoskeleton organization|regulation of Rac protein signal transduction|negative regulation of Rac protein signal transduction|regulation of GTPase activity|dendritic spine|positive regulation of GTPase activity|presynaptic active zone|regulation of small GTPase mediated signal transduction|negative regulation of filopodium assembly|recycling endosome|regulation of dendritic spine morphogenesis|modification of dendritic spine|neurotransmitter receptor transport, endosome to postsynaptic membrane|glutamatergic synapse|regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane" ARHGAP45 896.5498023 915.5642167 877.5353878 0.958464051 -0.061203773 0.809271489 1 8.86787287 8.357309105 23526 Rho GTPase activating protein 45 "GO:0005096,GO:0005515,GO:0005576,GO:0005829,GO:0016020,GO:0032587,GO:0034774,GO:0035556,GO:0035578,GO:0043312,GO:0046872,GO:0051056,GO:0090630" GTPase activator activity|protein binding|extracellular region|cytosol|membrane|ruffle membrane|secretory granule lumen|intracellular signal transduction|azurophil granule lumen|neutrophil degranulation|metal ion binding|regulation of small GTPase mediated signal transduction|activation of GTPase activity ARHGAP5 2368.242734 2597.913465 2138.572002 0.823188313 -0.280705595 0.235015169 1 10.06503571 8.146774483 394 Rho GTPase activating protein 5 "GO:0003924,GO:0005096,GO:0005515,GO:0005525,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0007155,GO:0007266,GO:0030879,GO:0042169,GO:0043547,GO:0051056" GTPase activity|GTPase activator activity|protein binding|GTP binding|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|cell adhesion|Rho protein signal transduction|mammary gland development|SH2 domain binding|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction "hsa04510,hsa04670" Focal adhesion|Leukocyte transendothelial migration ARHGAP6 44.18802189 62.42483296 25.95121081 0.415719347 -1.266318203 0.044501288 1 0.512774912 0.209603333 395 Rho GTPase activating protein 6 "GO:0005096,GO:0005737,GO:0005829,GO:0005884,GO:0007202,GO:0007266,GO:0015629,GO:0016004,GO:0017124,GO:0030041,GO:0043274,GO:0043547,GO:0048041,GO:0051056,GO:0051497,GO:0051895" GTPase activator activity|cytoplasm|cytosol|actin filament|activation of phospholipase C activity|Rho protein signal transduction|actin cytoskeleton|phospholipase activator activity|SH3 domain binding|actin filament polymerization|phospholipase binding|positive regulation of GTPase activity|focal adhesion assembly|regulation of small GTPase mediated signal transduction|negative regulation of stress fiber assembly|negative regulation of focal adhesion assembly ARHGDIA 8738.166245 8107.945387 9368.387103 1.155457598 0.208464318 0.401398551 1 196.5952492 223.3563018 396 Rho GDP dissociation inhibitor alpha "GO:0005094,GO:0005096,GO:0005515,GO:0005829,GO:0005856,GO:0007162,GO:0007266,GO:0016020,GO:0035023,GO:0043066,GO:0043547,GO:0050771,GO:0050772,GO:0051056,GO:0070062,GO:0071526,GO:2000249" Rho GDP-dissociation inhibitor activity|GTPase activator activity|protein binding|cytosol|cytoskeleton|negative regulation of cell adhesion|Rho protein signal transduction|membrane|regulation of Rho protein signal transduction|negative regulation of apoptotic process|positive regulation of GTPase activity|negative regulation of axonogenesis|positive regulation of axonogenesis|regulation of small GTPase mediated signal transduction|extracellular exosome|semaphorin-plexin signaling pathway|regulation of actin cytoskeleton reorganization "hsa04722,hsa04962" Neurotrophin signaling pathway|Vasopressin-regulated water reabsorption ARHGDIB 129.1264067 71.7885579 186.4642555 2.597409126 1.377073275 0.001537172 0.247303919 2.240481517 5.722066572 397 Rho GDP dissociation inhibitor beta "GO:0003924,GO:0005094,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0007162,GO:0007266,GO:0007275,GO:0016020,GO:0031267,GO:0031410,GO:0035023,GO:0043547,GO:0051056,GO:0070062,GO:0071461,GO:1901164,GO:2000249" GTPase activity|Rho GDP-dissociation inhibitor activity|GTPase activator activity|protein binding|cytoplasm|cytosol|cytoskeleton|negative regulation of cell adhesion|Rho protein signal transduction|multicellular organism development|membrane|small GTPase binding|cytoplasmic vesicle|regulation of Rho protein signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|extracellular exosome|cellular response to redox state|negative regulation of trophoblast cell migration|regulation of actin cytoskeleton reorganization "hsa04722,hsa04962" Neurotrophin signaling pathway|Vasopressin-regulated water reabsorption ARHGEF1 1625.666583 1611.601104 1639.732061 1.017455285 0.024965393 0.919061725 1 26.22200882 26.23327245 9138 Rho guanine nucleotide exchange factor 1 "GO:0001664,GO:0003723,GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007186,GO:0007266,GO:0043065,GO:0043547,GO:0051056" G protein-coupled receptor binding|RNA binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytoplasm|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|Rho protein signal transduction|positive regulation of apoptotic process|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction "hsa04270,hsa04611,hsa04810,hsa04928,hsa05130,hsa05135,hsa05163,hsa05200,hsa05205" "Vascular smooth muscle contraction|Platelet activation|Regulation of actin cytoskeleton|Parathyroid hormone synthesis, secretion and action|Pathogenic Escherichia coli infection|Yersinia infection|Human cytomegalovirus infection|Pathways in cancer|Proteoglycans in cancer" ARHGEF10 1301.634337 1419.124536 1184.144138 0.834418762 -0.261156498 0.277966836 1 12.71379356 10.43110686 9639 Rho guanine nucleotide exchange factor 10 "GO:0005085,GO:0005515,GO:0005813,GO:0005829,GO:0019894,GO:0022011,GO:0030036,GO:0035023,GO:0051298,GO:0051496,GO:0090307,GO:0090630" guanyl-nucleotide exchange factor activity|protein binding|centrosome|cytosol|kinesin binding|myelination in peripheral nervous system|actin cytoskeleton organization|regulation of Rho protein signal transduction|centrosome duplication|positive regulation of stress fiber assembly|mitotic spindle assembly|activation of GTPase activity ARHGEF10L 107.2079037 101.9605605 112.4552469 1.102928881 0.141339766 0.773800185 1 0.612292981 0.664015119 55160 Rho guanine nucleotide exchange factor 10 like "GO:0005096,GO:0005829,GO:0030036,GO:0032933,GO:0043547,GO:0051496" GTPase activator activity|cytosol|actin cytoskeleton organization|SREBP signaling pathway|positive regulation of GTPase activity|positive regulation of stress fiber assembly ARHGEF11 955.0803216 1064.343402 845.8172413 0.794684535 -0.331545826 0.179233849 1 6.838677002 5.343650334 9826 Rho guanine nucleotide exchange factor 11 "GO:0001558,GO:0001664,GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0006941,GO:0007186,GO:0007266,GO:0016020,GO:0030010,GO:0030036,GO:0043065,GO:0043547,GO:0045893,GO:0051056" "regulation of cell growth|G protein-coupled receptor binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytoplasm|cytosol|striated muscle contraction|G protein-coupled receptor signaling pathway|Rho protein signal transduction|membrane|establishment of cell polarity|actin cytoskeleton organization|positive regulation of apoptotic process|positive regulation of GTPase activity|positive regulation of transcription, DNA-templated|regulation of small GTPase mediated signal transduction" "hsa04270,hsa04928,hsa05130,hsa05163,hsa05200" "Vascular smooth muscle contraction|Parathyroid hormone synthesis, secretion and action|Pathogenic Escherichia coli infection|Human cytomegalovirus infection|Pathways in cancer" ARHGEF12 5881.672107 6166.533082 5596.811132 0.907610655 -0.139854549 0.563356356 1 29.27905133 26.12929942 23365 Rho guanine nucleotide exchange factor 12 "GO:0001664,GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0007186,GO:0007266,GO:0016020,GO:0043065,GO:0043547,GO:0051056,GO:0070062" G protein-coupled receptor binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytoplasm|cytosol|G protein-coupled receptor signaling pathway|Rho protein signal transduction|membrane|positive regulation of apoptotic process|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|extracellular exosome "hsa04270,hsa04360,hsa04611,hsa04625,hsa04810,hsa05130,hsa05135,hsa05152,hsa05163,hsa05200,hsa05205" Vascular smooth muscle contraction|Axon guidance|Platelet activation|C-type lectin receptor signaling pathway|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Yersinia infection|Tuberculosis|Human cytomegalovirus infection|Pathways in cancer|Proteoglycans in cancer ARHGEF16 13.97135991 13.52538047 14.41733934 1.065947044 0.092135768 1 1 0.185606762 0.194536278 27237 Rho guanine nucleotide exchange factor 16 "GO:0005085,GO:0005515,GO:0005829,GO:0007186,GO:0030165,GO:0030971,GO:0031267,GO:0043065,GO:0045296,GO:0051056,GO:0060326,GO:0090630,GO:1903078" guanyl-nucleotide exchange factor activity|protein binding|cytosol|G protein-coupled receptor signaling pathway|PDZ domain binding|receptor tyrosine kinase binding|small GTPase binding|positive regulation of apoptotic process|cadherin binding|regulation of small GTPase mediated signal transduction|cell chemotaxis|activation of GTPase activity|positive regulation of protein localization to plasma membrane ARHGEF17 1046.344864 1176.708101 915.9816261 0.778427229 -0.36136592 0.139880383 1 6.012902017 4.602283039 9828 Rho guanine nucleotide exchange factor 17 "GO:0005085,GO:0005515,GO:0005829,GO:0007186,GO:0030036,GO:0043065,GO:0050790,GO:0051056" guanyl-nucleotide exchange factor activity|protein binding|cytosol|G protein-coupled receptor signaling pathway|actin cytoskeleton organization|positive regulation of apoptotic process|regulation of catalytic activity|regulation of small GTPase mediated signal transduction ARHGEF18 1447.353874 1358.780531 1535.927218 1.130371817 0.176797401 0.460432597 1 8.627676335 9.589287595 23370 Rho/Rac guanine nucleotide exchange factor 18 "GO:0005085,GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0007179,GO:0007186,GO:0007264,GO:0008360,GO:0016324,GO:0030036,GO:0030054,GO:0035023,GO:0043065,GO:0045177,GO:0046872,GO:0050790,GO:0051056,GO:0051497,GO:0070062,GO:0150105" guanyl-nucleotide exchange factor activity|protein binding|cytosol|cytoskeleton|plasma membrane|transforming growth factor beta receptor signaling pathway|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|regulation of cell shape|apical plasma membrane|actin cytoskeleton organization|cell junction|regulation of Rho protein signal transduction|positive regulation of apoptotic process|apical part of cell|metal ion binding|regulation of catalytic activity|regulation of small GTPase mediated signal transduction|negative regulation of stress fiber assembly|extracellular exosome|protein localization to cell-cell junction hsa04530 Tight junction ARHGEF19 509.6819571 524.3685969 494.9953173 0.943983527 -0.083166411 0.765680975 1 8.125606349 7.542084136 128272 Rho guanine nucleotide exchange factor 19 "GO:0005096,GO:0005515,GO:0005829,GO:0007186,GO:0032956,GO:0042060,GO:0043065,GO:0051056,GO:0060071,GO:0090630" "GTPase activator activity|protein binding|cytosol|G protein-coupled receptor signaling pathway|regulation of actin cytoskeleton organization|wound healing|positive regulation of apoptotic process|regulation of small GTPase mediated signal transduction|Wnt signaling pathway, planar cell polarity pathway|activation of GTPase activity" ARHGEF2 2994.24787 3362.617669 2625.878072 0.780902954 -0.356784824 0.131848524 1 25.25425341 19.39111485 9181 Rho/Rac guanine nucleotide exchange factor 2 "GO:0000902,GO:0005085,GO:0005515,GO:0005737,GO:0005794,GO:0005819,GO:0005829,GO:0005856,GO:0005874,GO:0005923,GO:0005925,GO:0006886,GO:0007015,GO:0007026,GO:0007049,GO:0007186,GO:0008017,GO:0008134,GO:0008270,GO:0031267,GO:0031410,GO:0031982,GO:0032587,GO:0032755,GO:0032760,GO:0032991,GO:0035023,GO:0035556,GO:0042127,GO:0043065,GO:0045087,GO:0045666,GO:0045944,GO:0050731,GO:0050790,GO:0051056,GO:0051092,GO:0055059,GO:0060546,GO:0071225,GO:0071356,GO:0071474,GO:1902042,GO:1902219,GO:2001224" cell morphogenesis|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|Golgi apparatus|spindle|cytosol|cytoskeleton|microtubule|bicellular tight junction|focal adhesion|intracellular protein transport|actin filament organization|negative regulation of microtubule depolymerization|cell cycle|G protein-coupled receptor signaling pathway|microtubule binding|transcription factor binding|zinc ion binding|small GTPase binding|cytoplasmic vesicle|vesicle|ruffle membrane|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|protein-containing complex|regulation of Rho protein signal transduction|intracellular signal transduction|regulation of cell population proliferation|positive regulation of apoptotic process|innate immune response|positive regulation of neuron differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of peptidyl-tyrosine phosphorylation|regulation of catalytic activity|regulation of small GTPase mediated signal transduction|positive regulation of NF-kappaB transcription factor activity|asymmetric neuroblast division|negative regulation of necroptotic process|cellular response to muramyl dipeptide|cellular response to tumor necrosis factor|cellular hyperosmotic response|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|positive regulation of neuron migration "hsa04530,hsa05130,hsa05131,hsa05418" Tight junction|Pathogenic Escherichia coli infection|Shigellosis|Fluid shear stress and atherosclerosis ARHGEF25 650.5900699 577.4297049 723.7504349 1.253400074 0.325846984 0.208992325 1 10.74115095 13.237675 115557 Rho guanine nucleotide exchange factor 25 "GO:0005085,GO:0005829,GO:0005886,GO:0007186,GO:0030016,GO:0030017,GO:0035023,GO:0050790" guanyl-nucleotide exchange factor activity|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|myofibril|sarcomere|regulation of Rho protein signal transduction|regulation of catalytic activity ARHGEF26 140.1841162 160.2237379 120.1444945 0.749854523 -0.415317366 0.320235239 1 2.289383243 1.687977656 26084 Rho guanine nucleotide exchange factor 26 "GO:0001726,GO:0001886,GO:0005829,GO:0007186,GO:0043065,GO:0051056,GO:0090630,GO:0097178" ruffle|endothelial cell morphogenesis|cytosol|G protein-coupled receptor signaling pathway|positive regulation of apoptotic process|regulation of small GTPase mediated signal transduction|activation of GTPase activity|ruffle assembly "hsa05100,hsa05132" Bacterial invasion of epithelial cells|Salmonella infection ARHGEF28 2346.394042 2554.216082 2138.572002 0.837271372 -0.256232798 0.278397567 1 15.89109557 13.08251556 64283 Rho guanine nucleotide exchange factor 28 "GO:0000902,GO:0003723,GO:0005085,GO:0005829,GO:0005886,GO:0030154,GO:0035023,GO:0035556,GO:0046872,GO:0048013,GO:0050790" cell morphogenesis|RNA binding|guanyl-nucleotide exchange factor activity|cytosol|plasma membrane|cell differentiation|regulation of Rho protein signal transduction|intracellular signal transduction|metal ion binding|ephrin receptor signaling pathway|regulation of catalytic activity hsa05135 Yersinia infection ARHGEF3 274.5421604 268.4267817 280.6575392 1.045564594 0.064282194 0.853777482 1 2.354222513 2.420301977 50650 Rho guanine nucleotide exchange factor 3 "GO:0005515,GO:0005829,GO:0007186,GO:0007266,GO:0035025,GO:0043065,GO:0050790,GO:0051056" protein binding|cytosol|G protein-coupled receptor signaling pathway|Rho protein signal transduction|positive regulation of Rho protein signal transduction|positive regulation of apoptotic process|regulation of catalytic activity|regulation of small GTPase mediated signal transduction ARHGEF33 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.021060109 0.0286953 100271715 Rho guanine nucleotide exchange factor 33 "GO:0005085,GO:0050790" guanyl-nucleotide exchange factor activity|regulation of catalytic activity ARHGEF35 90.5958801 82.19269673 98.99906347 1.204475183 0.268404669 0.591846029 1 1.652155616 1.956680811 445328 Rho guanine nucleotide exchange factor 35 ARHGEF37 91.15068558 96.75849109 85.54288008 0.884086545 -0.17774049 0.729902815 1 0.974122399 0.846797348 389337 Rho guanine nucleotide exchange factor 37 "GO:0005737,GO:0050790" cytoplasm|regulation of catalytic activity ARHGEF39 314.3156618 353.7407201 274.8906034 0.777096296 -0.363834709 0.241258804 1 4.964105202 3.79303626 84904 Rho guanine nucleotide exchange factor 39 "GO:0005085,GO:0005515,GO:0005886,GO:0030335,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|plasma membrane|positive regulation of cell migration|regulation of catalytic activity ARHGEF4 128.9968446 194.5573961 63.4362931 0.32605439 -1.61681545 0.000218608 0.062280513 0.79079746 0.25352833 50649 Rho guanine nucleotide exchange factor 4 "GO:0005085,GO:0005515,GO:0005829,GO:0007186,GO:0019904,GO:0030032,GO:0032587,GO:0035556,GO:0043065,GO:0046847,GO:0050790,GO:0051056" guanyl-nucleotide exchange factor activity|protein binding|cytosol|G protein-coupled receptor signaling pathway|protein domain specific binding|lamellipodium assembly|ruffle membrane|intracellular signal transduction|positive regulation of apoptotic process|filopodium assembly|regulation of catalytic activity|regulation of small GTPase mediated signal transduction hsa04810 Regulation of actin cytoskeleton ARHGEF40 1484.863494 1397.275844 1572.451144 1.125369161 0.170398334 0.476297722 1 10.57731117 11.70419285 55701 Rho guanine nucleotide exchange factor 40 "GO:0005085,GO:0005829,GO:0005886,GO:0050790" guanyl-nucleotide exchange factor activity|cytosol|plasma membrane|regulation of catalytic activity ARHGEF5 398.045056 381.8318949 414.258217 1.084923032 0.117592696 0.690774269 1 3.713131643 3.961051182 7984 Rho guanine nucleotide exchange factor 5 "GO:0002102,GO:0005085,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0007186,GO:0008289,GO:0030054,GO:0032956,GO:0035556,GO:0042995,GO:0043065,GO:0043087,GO:0043507,GO:0051056,GO:0051091,GO:0051493,GO:0051496,GO:0070372,GO:0071944,GO:0090630,GO:1904591" podosome|guanyl-nucleotide exchange factor activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|lipid binding|cell junction|regulation of actin cytoskeleton organization|intracellular signal transduction|cell projection|positive regulation of apoptotic process|regulation of GTPase activity|positive regulation of JUN kinase activity|regulation of small GTPase mediated signal transduction|positive regulation of DNA-binding transcription factor activity|regulation of cytoskeleton organization|positive regulation of stress fiber assembly|regulation of ERK1 and ERK2 cascade|cell periphery|activation of GTPase activity|positive regulation of protein import ARHGEF6 117.9290742 131.0921492 104.7659992 0.799178287 -0.323410709 0.470517067 1 1.171687668 0.920718169 9459 Rac/Cdc42 guanine nucleotide exchange factor 6 "GO:0005085,GO:0005096,GO:0005515,GO:0005829,GO:0006915,GO:0007186,GO:0007254,GO:0030027,GO:0030032,GO:0043065,GO:0043547,GO:0051056" guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytosol|apoptotic process|G protein-coupled receptor signaling pathway|JNK cascade|lamellipodium|lamellipodium assembly|positive regulation of apoptotic process|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction "hsa04810,hsa05212" Regulation of actin cytoskeleton|Pancreatic cancer ARHGEF7 1084.118024 1058.100919 1110.135129 1.049176983 0.069258063 0.779708615 1 5.46173724 5.634439702 8874 Rho guanine nucleotide exchange factor 7 "GO:0001726,GO:0005085,GO:0005515,GO:0005829,GO:0005925,GO:0005938,GO:0007030,GO:0007165,GO:0007186,GO:0007399,GO:0010763,GO:0019901,GO:0030027,GO:0030032,GO:0032991,GO:0035556,GO:0042059,GO:0043005,GO:0043025,GO:0043065,GO:0043547,GO:0048013,GO:0048041,GO:0051056,GO:1900026,GO:1904424,GO:2000394" ruffle|guanyl-nucleotide exchange factor activity|protein binding|cytosol|focal adhesion|cell cortex|Golgi organization|signal transduction|G protein-coupled receptor signaling pathway|nervous system development|positive regulation of fibroblast migration|protein kinase binding|lamellipodium|lamellipodium assembly|protein-containing complex|intracellular signal transduction|negative regulation of epidermal growth factor receptor signaling pathway|neuron projection|neuronal cell body|positive regulation of apoptotic process|positive regulation of GTPase activity|ephrin receptor signaling pathway|focal adhesion assembly|regulation of small GTPase mediated signal transduction|positive regulation of substrate adhesion-dependent cell spreading|regulation of GTP binding|positive regulation of lamellipodium morphogenesis "hsa04810,hsa05135" Regulation of actin cytoskeleton|Yersinia infection ARHGEF9 408.8851134 414.0847253 403.6855015 0.974886242 -0.036694213 0.907135767 1 1.613650291 1.546801343 23229 Cdc42 guanine nucleotide exchange factor 9 "GO:0005085,GO:0005515,GO:0005829,GO:0007186,GO:0014069,GO:0043065,GO:0050790,GO:0051056" guanyl-nucleotide exchange factor activity|protein binding|cytosol|G protein-coupled receptor signaling pathway|postsynaptic density|positive regulation of apoptotic process|regulation of catalytic activity|regulation of small GTPase mediated signal transduction ARID1A 1501.067939 1633.449796 1368.686081 0.837911324 -0.255130523 0.285155932 1 10.14243321 8.356249429 8289 AT-rich interaction domain 1A "GO:0000785,GO:0003677,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006337,GO:0006338,GO:0006357,GO:0007399,GO:0016514,GO:0016922,GO:0030520,GO:0030521,GO:0031491,GO:0035060,GO:0042766,GO:0042921,GO:0043044,GO:0045893,GO:0048096,GO:0071564,GO:0071565" "chromatin|DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|nervous system development|SWI/SNF complex|nuclear receptor binding|intracellular estrogen receptor signaling pathway|androgen receptor signaling pathway|nucleosome binding|brahma complex|nucleosome mobilization|glucocorticoid receptor signaling pathway|ATP-dependent chromatin remodeling|positive regulation of transcription, DNA-templated|chromatin-mediated maintenance of transcription|npBAF complex|nBAF complex" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma chromosome_remodelling_factor ARID1B 618.5045874 693.9560597 543.0531151 0.782546831 -0.353751004 0.176051865 1 4.348891436 3.346263079 57492 AT-rich interaction domain 1B "GO:0002931,GO:0003677,GO:0003713,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006357,GO:0007399,GO:0016514,GO:0031491,GO:0035060,GO:0043044,GO:0045893,GO:0048096,GO:0071565,GO:1904385" "response to ischemia|DNA binding|transcription coactivator activity|protein binding|nucleoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|nervous system development|SWI/SNF complex|nucleosome binding|brahma complex|ATP-dependent chromatin remodeling|positive regulation of transcription, DNA-templated|chromatin-mediated maintenance of transcription|nBAF complex|cellular response to angiotensin" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma ARID ARID2 948.2088053 1022.726847 873.690764 0.85427577 -0.227226232 0.358336007 1 6.24640102 5.246855811 196528 AT-rich interaction domain 2 "GO:0003007,GO:0003677,GO:0005515,GO:0005654,GO:0005886,GO:0006337,GO:0006355,GO:0008285,GO:0030336,GO:0042592,GO:0046872,GO:0048568,GO:0060038,GO:0060982,GO:1905168" "heart morphogenesis|DNA binding|protein binding|nucleoplasm|plasma membrane|nucleosome disassembly|regulation of transcription, DNA-templated|negative regulation of cell population proliferation|negative regulation of cell migration|homeostatic process|metal ion binding|embryonic organ development|cardiac muscle cell proliferation|coronary artery morphogenesis|positive regulation of double-strand break repair via homologous recombination" hsa05225 Hepatocellular carcinoma RFX ARID3A 348.927337 328.7707869 369.0838871 1.122617647 0.166866643 0.583931331 1 2.390448589 2.638654031 1820 AT-rich interaction domain 3A "GO:0003677,GO:0003682,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006977,GO:0042802,GO:0045121,GO:0045944" "DNA binding|chromatin binding|transcription coregulator activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|identical protein binding|membrane raft|positive regulation of transcription by RNA polymerase II" ARID ARID3B 343.1258027 315.2454064 371.006199 1.176880587 0.234967944 0.43978304 1 3.976380984 4.601416717 10620 AT-rich interaction domain 3B "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008150,GO:0045944" DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|biological_process|positive regulation of transcription by RNA polymerase II ARID3C 6.604174384 9.363724944 3.844623824 0.41058701 -1.284240111 0.3924594 1 0.105560792 0.042616622 138715 AT-rich interaction domain 3C "GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0045121,GO:0045944" DNA binding|chromatin binding|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|membrane raft|positive regulation of transcription by RNA polymerase II ARID4A 478.2959335 495.2370081 461.3548589 0.931583972 -0.102242278 0.716745981 1 3.46303576 3.172124048 5926 AT-rich interaction domain 4A "GO:0000976,GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006349,GO:0006357,GO:0007283,GO:0017053,GO:0034773,GO:0036124,GO:0045892,GO:0045944,GO:0048821,GO:0080182,GO:0097368" "transcription regulatory region sequence-specific DNA binding|DNA binding|nucleus|nucleoplasm|cytosol|plasma membrane|regulation of gene expression by genetic imprinting|regulation of transcription by RNA polymerase II|spermatogenesis|transcription repressor complex|histone H4-K20 trimethylation|histone H3-K9 trimethylation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|erythrocyte development|histone H3-K4 trimethylation|establishment of Sertoli cell barrier" ARID4B 741.2891312 801.1186896 681.4595728 0.85063497 -0.233387928 0.359270165 1 6.195367638 5.181810115 51742 AT-rich interaction domain 4B "GO:0000976,GO:0003674,GO:0005515,GO:0005575,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006325,GO:0006357,GO:0008150" transcription regulatory region sequence-specific DNA binding|molecular_function|protein binding|cellular_component|nucleus|nucleoplasm|mitochondrion|cytosol|chromatin organization|regulation of transcription by RNA polymerase II|biological_process ARID5A 176.8961265 190.3957405 163.3965125 0.85819416 -0.220624012 0.569821554 1 2.131991343 1.799045594 10865 AT-rich interaction domain 5A "GO:0000122,GO:0000976,GO:0003677,GO:0003714,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0008134,GO:0030331,GO:0042802,GO:0043565,GO:0045087,GO:0045892,GO:0046965,GO:0046966,GO:0050681,GO:0071391" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|DNA binding|transcription corepressor activity|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|transcription factor binding|estrogen receptor binding|identical protein binding|sequence-specific DNA binding|innate immune response|negative regulation of transcription, DNA-templated|retinoid X receptor binding|thyroid hormone receptor binding|androgen receptor binding|cellular response to estrogen stimulus" ARID5B 582.7040433 687.7135764 477.6945101 0.694612592 -0.52571953 0.046707822 1 3.64035009 2.486319764 84159 AT-rich interaction domain 5B "GO:0000122,GO:0000976,GO:0001822,GO:0001889,GO:0003677,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006807,GO:0008584,GO:0008585,GO:0009791,GO:0010761,GO:0030325,GO:0035264,GO:0045444,GO:0045892,GO:0045893,GO:0048008,GO:0048468,GO:0048644,GO:0048705,GO:0051091,GO:0060021,GO:0060325,GO:0060612,GO:0060613,GO:1990830" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|kidney development|liver development|DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|nitrogen compound metabolic process|male gonad development|female gonad development|post-embryonic development|fibroblast migration|adrenal gland development|multicellular organism growth|fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|platelet-derived growth factor receptor signaling pathway|cell development|muscle organ morphogenesis|skeletal system morphogenesis|positive regulation of DNA-binding transcription factor activity|roof of mouth development|face morphogenesis|adipose tissue development|fat pad development|cellular response to leukemia inhibitory factor" ARIH1 2219.255957 2219.202812 2219.309102 1.000047896 6.91E-05 1 1 5.46311063 5.371950154 25820 ariadne RBR E3 ubiquitin protein ligase 1 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006511,GO:0008270,GO:0015030,GO:0016567,GO:0016604,GO:0018215,GO:0019005,GO:0019787,GO:0031462,GO:0031463,GO:0031464,GO:0031624,GO:0031625,GO:0032436,GO:0061630,GO:0097413" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|zinc ion binding|Cajal body|protein ubiquitination|nuclear body|protein phosphopantetheinylation|SCF ubiquitin ligase complex|ubiquitin-like protein transferase activity|Cul2-RING ubiquitin ligase complex|Cul3-RING ubiquitin ligase complex|Cul4A-RING E3 ubiquitin ligase complex|ubiquitin conjugating enzyme binding|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity|Lewy body ARIH2 2089.981095 2118.282665 2061.679526 0.97327876 -0.039075024 0.870653888 1 14.3390224 13.72233342 10425 ariadne RBR E3 ubiquitin protein ligase 2 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006511,GO:0007275,GO:0008270,GO:0016567,GO:0031466,GO:0031624,GO:0032436,GO:0048588,GO:0061630,GO:0070534,GO:0070936,GO:0071425,GO:1903955" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|ubiquitin-dependent protein catabolic process|multicellular organism development|zinc ion binding|protein ubiquitination|Cul5-RING ubiquitin ligase complex|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|developmental cell growth|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|hematopoietic stem cell proliferation|positive regulation of protein targeting to mitochondrion ARL1 2089.15073 1793.673534 2384.627927 1.329465971 0.410846851 0.082493073 1 29.49924803 38.5619822 400 ADP ribosylation factor like GTPase 1 "GO:0003924,GO:0005525,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0006886,GO:0007030,GO:0008047,GO:0009404,GO:0016192,GO:0019904,GO:0031584,GO:0032588,GO:0034067,GO:0042147,GO:0046872" "GTPase activity|GTP binding|cytoplasm|Golgi apparatus|trans-Golgi network|cytosol|intracellular protein transport|Golgi organization|enzyme activator activity|toxin metabolic process|vesicle-mediated transport|protein domain specific binding|activation of phospholipase D activity|trans-Golgi network membrane|protein localization to Golgi apparatus|retrograde transport, endosome to Golgi|metal ion binding" ARL10 92.50813117 107.1626299 77.85363244 0.72649983 -0.460965634 0.341337857 1 0.485531251 0.346835772 285598 ADP ribosylation factor like GTPase 10 GO:0005525 GTP binding ARL13B 880.3787277 894.7559391 866.0015164 0.96786339 -0.047124664 0.854098953 1 11.18825679 10.64750044 200894 ADP ribosylation factor like GTPase 13B "GO:0005515,GO:0005525,GO:0005929,GO:0007224,GO:0021532,GO:0021830,GO:0021943,GO:0031514,GO:0060170,GO:0060271,GO:0097500,GO:0097730,GO:1905515" protein binding|GTP binding|cilium|smoothened signaling pathway|neural tube patterning|interneuron migration from the subpallium to the cortex|formation of radial glial scaffolds|motile cilium|ciliary membrane|cilium assembly|receptor localization to non-motile cilium|non-motile cilium|non-motile cilium assembly ARL14 9.844302922 18.72744989 0.961155956 0.051323376 -4.284240111 0.00411441 0.390726074 0.775368178 0.039128605 80117 ADP ribosylation factor like GTPase 14 "GO:0005515,GO:0005525,GO:0005737,GO:0005886,GO:0006886,GO:0016192,GO:0031410" protein binding|GTP binding|cytoplasm|plasma membrane|intracellular protein transport|vesicle-mediated transport|cytoplasmic vesicle ARL14EP 529.6284584 518.1261136 541.1308032 1.044399788 0.06267407 0.82260821 1 9.11385577 9.359229677 120534 ADP ribosylation factor like GTPase 14 effector protein "GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0005925,GO:0043231" protein binding|nucleoplasm|nucleolus|cytosol|plasma membrane|focal adhesion|intracellular membrane-bounded organelle ARL14EPL 23.69677594 29.13158871 18.26196316 0.626878381 -0.673742519 0.410330815 1 0.934876337 0.576246948 644100 ADP ribosylation factor like GTPase 14 effector protein like ARL15 391.594367 389.1147921 394.073942 1.012744696 0.01827053 0.959597971 1 5.779666377 5.755378978 54622 ADP ribosylation factor like GTPase 15 "GO:0003674,GO:0005515,GO:0005525,GO:0008150,GO:0070062" molecular_function|protein binding|GTP binding|biological_process|extracellular exosome ARL16 623.8513102 544.1364606 703.5661598 1.292995803 0.370717592 0.155743256 1 24.50596019 31.15587964 339231 ADP ribosylation factor like GTPase 16 "GO:0005515,GO:0005525" protein binding|GTP binding ARL17A 89.10948678 93.63724944 84.58172413 0.903291421 -0.146736588 0.782282621 1 0.532188275 0.472676887 51326 ADP ribosylation factor like GTPase 17A ARL17B 101.5598548 105.0818021 98.03790751 0.932967512 -0.100101251 0.849384607 1 0.606797517 0.556649078 100506084 ADP ribosylation factor like GTPase 17B "GO:0005525,GO:0005737,GO:0005794,GO:0005886,GO:0006886,GO:0016192" GTP binding|cytoplasm|Golgi apparatus|plasma membrane|intracellular protein transport|vesicle-mediated transport ARL2 1553.635835 1373.346325 1733.925345 1.262555055 0.336346299 0.158117886 1 78.64052496 97.62654221 402 ADP ribosylation factor like GTPase 2 "GO:0003924,GO:0005095,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005758,GO:0005759,GO:0005794,GO:0005813,GO:0005829,GO:0005925,GO:0005929,GO:0007021,GO:0007098,GO:0010811,GO:0015630,GO:0016328,GO:0019003,GO:0031113,GO:0031116,GO:0034260,GO:0050796,GO:0051457,GO:0070830" GTPase activity|GTPase inhibitor activity|protein binding|GTP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrial intermembrane space|mitochondrial matrix|Golgi apparatus|centrosome|cytosol|focal adhesion|cilium|tubulin complex assembly|centrosome cycle|positive regulation of cell-substrate adhesion|microtubule cytoskeleton|lateral plasma membrane|GDP binding|regulation of microtubule polymerization|positive regulation of microtubule polymerization|negative regulation of GTPase activity|regulation of insulin secretion|maintenance of protein location in nucleus|bicellular tight junction assembly ARL2BP 1112.324898 827.1290367 1397.52076 1.689604279 0.756685394 0.001967655 0.275095265 22.41866759 37.24482835 23568 ADP ribosylation factor like GTPase 2 binding protein "GO:0003713,GO:0005515,GO:0005634,GO:0005758,GO:0005759,GO:0005813,GO:0005819,GO:0005829,GO:0005929,GO:0007165,GO:0030496,GO:0030695,GO:0042531,GO:0045893,GO:0050790,GO:0050796,GO:0051457" "transcription coactivator activity|protein binding|nucleus|mitochondrial intermembrane space|mitochondrial matrix|centrosome|spindle|cytosol|cilium|signal transduction|midbody|GTPase regulator activity|positive regulation of tyrosine phosphorylation of STAT protein|positive regulation of transcription, DNA-templated|regulation of catalytic activity|regulation of insulin secretion|maintenance of protein location in nucleus" ARL3 1519.207828 1340.053081 1698.362574 1.267384553 0.341854337 0.151825043 1 17.10503947 21.31589973 403 ADP ribosylation factor like GTPase 3 "GO:0000139,GO:0000281,GO:0000287,GO:0001822,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005813,GO:0005876,GO:0005881,GO:0005929,GO:0006892,GO:0006893,GO:0007224,GO:0007264,GO:0008017,GO:0015630,GO:0019003,GO:0030496,GO:0032391,GO:0032794,GO:0042073,GO:0042461,GO:0060271,GO:0061512,GO:0070062,GO:1903441" Golgi membrane|mitotic cytokinesis|magnesium ion binding|kidney development|GTPase activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|centrosome|spindle microtubule|cytoplasmic microtubule|cilium|post-Golgi vesicle-mediated transport|Golgi to plasma membrane transport|smoothened signaling pathway|small GTPase mediated signal transduction|microtubule binding|microtubule cytoskeleton|GDP binding|midbody|photoreceptor connecting cilium|GTPase activating protein binding|intraciliary transport|photoreceptor cell development|cilium assembly|protein localization to cilium|extracellular exosome|protein localization to ciliary membrane ARL4A 332.8009218 296.5179566 369.0838871 1.244726935 0.315829282 0.301622125 1 5.222646325 6.391986992 10124 ADP ribosylation factor like GTPase 4A "GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006886,GO:0016192,GO:0050873" protein binding|GTP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|intracellular protein transport|vesicle-mediated transport|brown fat cell differentiation ARL4C 2500.867779 2534.448218 2467.287339 0.973500789 -0.038745947 0.871365092 1 33.47162665 32.03939487 10123 ADP ribosylation factor like GTPase 4C "GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006886,GO:0016192,GO:0030175,GO:0032456,GO:0043014" GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|cytosol|plasma membrane|intracellular protein transport|vesicle-mediated transport|filopodium|endocytic recycling|alpha-tubulin binding ARL4D 291.6297316 300.6796121 282.5798511 0.93980383 -0.089568448 0.786893557 1 9.942204629 9.187367456 379 ADP ribosylation factor like GTPase 4D "GO:0003924,GO:0005515,GO:0005525,GO:0005730,GO:0005737,GO:0005886,GO:0006886,GO:0009306,GO:0016192" GTPase activity|protein binding|GTP binding|nucleolus|cytoplasm|plasma membrane|intracellular protein transport|protein secretion|vesicle-mediated transport ARL5A 1191.732278 1145.495685 1237.968871 1.08072766 0.112003015 0.645882094 1 11.61341173 12.34091239 26225 ADP ribosylation factor like GTPase 5A "GO:0005525,GO:0005737,GO:0005802,GO:0006886,GO:0016192,GO:1903292" GTP binding|cytoplasm|trans-Golgi network|intracellular protein transport|vesicle-mediated transport|protein localization to Golgi membrane ARL5B 731.1177358 799.0378619 663.1976096 0.829995225 -0.268825059 0.291489857 1 5.738552297 4.683269133 221079 ADP ribosylation factor like GTPase 5B "GO:0005515,GO:0005525,GO:0005737,GO:0005802,GO:0006886,GO:0016192,GO:1903292" protein binding|GTP binding|cytoplasm|trans-Golgi network|intracellular protein transport|vesicle-mediated transport|protein localization to Golgi membrane ARL6 257.9401977 223.6889848 292.1914106 1.306239603 0.385419554 0.245985016 1 1.884133522 2.419946149 84100 ADP ribosylation factor like GTPase 6 "GO:0003924,GO:0005515,GO:0005525,GO:0005543,GO:0005737,GO:0005879,GO:0005886,GO:0005929,GO:0005930,GO:0006612,GO:0006886,GO:0007368,GO:0007601,GO:0016020,GO:0016055,GO:0016192,GO:0030117,GO:0032402,GO:0046872,GO:0051258,GO:0060271,GO:0061512,GO:0070062" GTPase activity|protein binding|GTP binding|phospholipid binding|cytoplasm|axonemal microtubule|plasma membrane|cilium|axoneme|protein targeting to membrane|intracellular protein transport|determination of left/right symmetry|visual perception|membrane|Wnt signaling pathway|vesicle-mediated transport|membrane coat|melanosome transport|metal ion binding|protein polymerization|cilium assembly|protein localization to cilium|extracellular exosome ARL6IP1 6068.932129 6477.616833 5660.247425 0.873816339 -0.194598013 0.422006656 1 140.9863397 121.1346462 23204 ADP ribosylation factor like GTPase 6 interacting protein 1 "GO:0002038,GO:0005515,GO:0005784,GO:0005789,GO:0006613,GO:0006915,GO:0016020,GO:0016021,GO:0030176,GO:0042802,GO:0043066,GO:0043154,GO:0071787,GO:1903371,GO:1990809" positive regulation of L-glutamate import across plasma membrane|protein binding|Sec61 translocon complex|endoplasmic reticulum membrane|cotranslational protein targeting to membrane|apoptotic process|membrane|integral component of membrane|integral component of endoplasmic reticulum membrane|identical protein binding|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|endoplasmic reticulum tubular network formation|regulation of endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network membrane organization ARL6IP4 2073.01364 1887.310783 2258.716497 1.196790967 0.259171191 0.273315896 1 84.42775169 99.35156333 51329 ADP ribosylation factor like GTPase 6 interacting protein 4 "GO:0003723,GO:0005515,GO:0005634,GO:0005730,GO:0006397,GO:0008380,GO:0016607" RNA binding|protein binding|nucleus|nucleolus|mRNA processing|RNA splicing|nuclear speck ARL6IP5 1832.790046 1725.006217 1940.573875 1.124966308 0.169881794 0.474141903 1 43.13983664 47.71876448 10550 ADP ribosylation factor like GTPase 6 interacting protein 5 "GO:0002037,GO:0003674,GO:0005515,GO:0005789,GO:0005856,GO:0005886,GO:0006749,GO:0007611,GO:0008631,GO:0010917,GO:0015813,GO:0016020,GO:0016021,GO:0032874,GO:0036475,GO:0043065,GO:0043280,GO:0051051,GO:0072659,GO:0098712" negative regulation of L-glutamate import across plasma membrane|molecular_function|protein binding|endoplasmic reticulum membrane|cytoskeleton|plasma membrane|glutathione metabolic process|learning or memory|intrinsic apoptotic signaling pathway in response to oxidative stress|negative regulation of mitochondrial membrane potential|L-glutamate transmembrane transport|membrane|integral component of membrane|positive regulation of stress-activated MAPK cascade|neuron death in response to oxidative stress|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of transport|protein localization to plasma membrane|L-glutamate import across plasma membrane ARL6IP6 1166.807004 1084.111266 1249.502743 1.152559504 0.204841236 0.399362942 1 15.62436558 17.70667137 151188 ADP ribosylation factor like GTPase 6 interacting protein 6 "GO:0005515,GO:0005637,GO:0016021" protein binding|nuclear inner membrane|integral component of membrane ARL8A 767.1120087 722.0472346 812.1767828 1.124825003 0.169700569 0.504340118 1 21.5395941 23.82284664 127829 ADP ribosylation factor like GTPase 8A "GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005765,GO:0005774,GO:0005886,GO:0007049,GO:0007059,GO:0008089,GO:0015031,GO:0016020,GO:0030496,GO:0031902,GO:0035577,GO:0043014,GO:0043312,GO:0045202,GO:0048487,GO:0051233,GO:0051301,GO:0070062,GO:0101003,GO:1904115" GTPase activity|protein binding|GTP binding|cytoplasm|lysosomal membrane|vacuolar membrane|plasma membrane|cell cycle|chromosome segregation|anterograde axonal transport|protein transport|membrane|midbody|late endosome membrane|azurophil granule membrane|alpha-tubulin binding|neutrophil degranulation|synapse|beta-tubulin binding|spindle midzone|cell division|extracellular exosome|ficolin-1-rich granule membrane|axon cytoplasm hsa05132 Salmonella infection ARL8B 2280.447876 2223.364467 2337.531285 1.051348674 0.072241211 0.76126591 1 40.45580472 41.82142188 55207 ADP ribosylation factor like GTPase 8B "GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005765,GO:0005774,GO:0007049,GO:0007059,GO:0008089,GO:0015031,GO:0016020,GO:0016197,GO:0019003,GO:0030496,GO:0031902,GO:0032418,GO:0043014,GO:0045202,GO:0048487,GO:0051233,GO:0051301,GO:0070062,GO:1904115" GTPase activity|protein binding|GTP binding|cytoplasm|lysosomal membrane|vacuolar membrane|cell cycle|chromosome segregation|anterograde axonal transport|protein transport|membrane|endosomal transport|GDP binding|midbody|late endosome membrane|lysosome localization|alpha-tubulin binding|synapse|beta-tubulin binding|spindle midzone|cell division|extracellular exosome|axon cytoplasm hsa05132 Salmonella infection ARMC1 2093.93516 2045.453693 2142.416626 1.04740412 0.066818185 0.779104476 1 35.21358201 36.26566632 55156 armadillo repeat containing 1 "GO:0005515,GO:0005739,GO:0005741,GO:0005829,GO:0030001,GO:0046872,GO:0048312" protein binding|mitochondrion|mitochondrial outer membrane|cytosol|metal ion transport|metal ion binding|intracellular distribution of mitochondria ARMC10 857.0832718 863.5435226 850.6230211 0.985037811 -0.021748991 0.935523506 1 10.52185632 10.19099168 83787 armadillo repeat containing 10 "GO:0005739,GO:0005783,GO:0005789,GO:0016021,GO:0040008,GO:1902254" mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|regulation of growth|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator ARMC12 7.604959303 10.40413883 4.80577978 0.461910386 -1.11431511 0.425432296 1 0.183979379 0.083559928 221481 armadillo repeat containing 12 GO:0005634 nucleus ARMC2 50.15813286 55.14193578 45.17432993 0.819237288 -0.287646713 0.651164013 1 0.62493603 0.503403759 84071 armadillo repeat containing 2 "GO:0005515,GO:0007288,GO:0044782" protein binding|sperm axoneme assembly|cilium organization ARMC5 119.2619821 103.0009744 135.5229898 1.315744736 0.395879622 0.372715968 1 1.261931289 1.632595249 79798 armadillo repeat containing 5 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005925" protein binding|nucleoplasm|cytoplasm|cytosol|focal adhesion hsa04934 Cushing syndrome ARMC6 257.0828374 264.2651262 249.9005486 0.94564331 -0.080631984 0.818443569 1 5.34217579 4.967257884 93436 armadillo repeat containing 6 "GO:0002244,GO:0005829" hematopoietic progenitor cell differentiation|cytosol ARMC7 255.5171861 273.6288511 237.4055211 0.867618748 -0.204866868 0.543138622 1 5.209799813 4.444481903 79637 armadillo repeat containing 7 GO:0005515 protein binding ARMC8 557.5214884 569.1063938 545.936583 0.959287383 -0.059965013 0.828256732 1 5.593400049 5.275890737 25852 armadillo repeat containing 8 "GO:0000151,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0034657,GO:0035580,GO:0043161,GO:0043231,GO:0043312,GO:1904724" ubiquitin ligase complex|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|GID complex|specific granule lumen|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|neutrophil degranulation|tertiary granule lumen ARMC9 854.4224865 907.2409057 801.6040673 0.883562527 -0.178595861 0.475988118 1 3.294623006 2.862293696 80210 armadillo repeat containing 9 "GO:0005737,GO:0005814,GO:0036064,GO:0045880,GO:0060271,GO:0070062,GO:0097542" cytoplasm|centriole|ciliary basal body|positive regulation of smoothened signaling pathway|cilium assembly|extracellular exosome|ciliary tip ARMCX1 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.078388202 0.071204855 51309 armadillo repeat containing X-linked 1 "GO:0005515,GO:0005739,GO:0005741,GO:0016021,GO:0061484" protein binding|mitochondrion|mitochondrial outer membrane|integral component of membrane|hematopoietic stem cell homeostasis ARMCX2 700.916165 712.6835096 689.1488204 0.966977363 -0.048445979 0.855236341 1 13.26634428 12.61359113 9823 armadillo repeat containing X-linked 2 "GO:0005739,GO:0005741,GO:0016021" mitochondrion|mitochondrial outer membrane|integral component of membrane ARMCX3 1815.241404 1743.733667 1886.749142 1.082016811 0.113722914 0.632646159 1 26.26583714 27.94450583 51566 armadillo repeat containing X-linked 3 "GO:0005515,GO:0005634,GO:0005739,GO:0005829,GO:0007005,GO:0019896,GO:0031307,GO:0034613,GO:0045944,GO:1904115" protein binding|nucleus|mitochondrion|cytosol|mitochondrion organization|axonal transport of mitochondrion|integral component of mitochondrial outer membrane|cellular protein localization|positive regulation of transcription by RNA polymerase II|axon cytoplasm ARMCX4 110.1209397 127.9709076 92.27097178 0.721030846 -0.471867115 0.299178053 1 0.919931592 0.652199643 100131755 armadillo repeat containing X-linked 4 GO:0016021 integral component of membrane ARMCX5 375.8642415 367.2661006 384.4623824 1.046822404 0.066016707 0.830774606 1 6.533438927 6.724902982 64860 armadillo repeat containing X-linked 5 GO:0005515 protein binding ARMCX5-GPRASP2 27.46214184 27.05076095 27.87352272 1.030415476 0.043226167 1 1 0.148753158 0.150712663 100528062 ARMCX5-GPRASP2 readthrough "GO:0001540,GO:0001664,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007611,GO:0042803,GO:0043524,GO:0050769,GO:0051965,GO:0061003,GO:0061484,GO:0070062" amyloid-beta binding|G protein-coupled receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|learning or memory|protein homodimerization activity|negative regulation of neuron apoptotic process|positive regulation of neurogenesis|positive regulation of synapse assembly|positive regulation of dendritic spine morphogenesis|hematopoietic stem cell homeostasis|extracellular exosome ARMCX6 484.7617137 450.4992112 519.0242162 1.152109046 0.204277272 0.460666675 1 12.43782458 14.08994158 54470 armadillo repeat containing X-linked 6 "GO:0005739,GO:0005741,GO:0016021" mitochondrion|mitochondrial outer membrane|integral component of membrane ARMH1 9.046693237 10.40413883 7.689247648 0.739056617 -0.436243205 0.791668951 1 0.147437538 0.107141311 339541 armadillo like helical domain containing 1 ARMH3 2206.478496 2224.404881 2188.552112 0.983882085 -0.023442671 0.922966883 1 21.1986429 20.5079519 79591 armadillo like helical domain containing 3 "GO:0000139,GO:0005515,GO:0005829,GO:0016021,GO:1903358" Golgi membrane|protein binding|cytosol|integral component of membrane|regulation of Golgi organization ARMH4 298.7295752 272.5884373 324.8707131 1.191799316 0.253141325 0.424883822 1 1.019378032 1.194564435 145407 armadillo like helical domain containing 4 GO:0016021 integral component of membrane ARMT1 602.7801067 558.702255 646.8579584 1.157786554 0.211369307 0.422914137 1 12.43926262 14.16101285 79624 acidic residue methyltransferase 1 "GO:0005515,GO:0006479,GO:0006974,GO:0008757,GO:0016311,GO:0016791,GO:0019899,GO:0032259,GO:0046872,GO:0051998,GO:2001020" protein binding|protein methylation|cellular response to DNA damage stimulus|S-adenosylmethionine-dependent methyltransferase activity|dephosphorylation|phosphatase activity|enzyme binding|methylation|metal ion binding|protein carboxyl O-methyltransferase activity|regulation of response to DNA damage stimulus ARNT 1471.559567 1615.76276 1327.356375 0.821504498 -0.28365962 0.235066923 1 17.96838692 14.51410349 405 aryl hydrocarbon receptor nuclear translocator "GO:0000785,GO:0000978,GO:0000981,GO:0000987,GO:0001666,GO:0001892,GO:0001938,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006805,GO:0008134,GO:0010575,GO:0016604,GO:0017162,GO:0030154,GO:0030522,GO:0030949,GO:0033235,GO:0034751,GO:0042803,GO:0043565,GO:0043619,GO:0045648,GO:0045821,GO:0045944,GO:0046886,GO:0046982,GO:0061418,GO:0090575,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|response to hypoxia|embryonic placenta development|positive regulation of endothelial cell proliferation|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|xenobiotic metabolic process|transcription factor binding|positive regulation of vascular endothelial growth factor production|nuclear body|aryl hydrocarbon receptor binding|cell differentiation|intracellular receptor signaling pathway|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of protein sumoylation|aryl hydrocarbon receptor complex|protein homodimerization activity|sequence-specific DNA binding|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|positive regulation of erythrocyte differentiation|positive regulation of glycolytic process|positive regulation of transcription by RNA polymerase II|positive regulation of hormone biosynthetic process|protein heterodimerization activity|regulation of transcription from RNA polymerase II promoter in response to hypoxia|RNA polymerase II transcription regulator complex|sequence-specific double-stranded DNA binding" "hsa04066,hsa04934,hsa05200,hsa05204,hsa05211" HIF-1 signaling pathway|Cushing syndrome|Pathways in cancer|Chemical carcinogenesis|Renal cell carcinoma bHLH ARNT2 7.124381325 10.40413883 3.844623824 0.369528309 -1.436243205 0.311438224 1 0.085121841 0.030928574 9915 aryl hydrocarbon receptor nuclear translocator 2 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001666,GO:0001701,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006355,GO:0006357,GO:0006805,GO:0007417,GO:0007420,GO:0008284,GO:0017162,GO:0032355,GO:0034751,GO:0043066,GO:0044877,GO:0045893,GO:0045944,GO:0046982,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|response to hypoxia|in utero embryonic development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|xenobiotic metabolic process|central nervous system development|brain development|positive regulation of cell population proliferation|aryl hydrocarbon receptor binding|response to estradiol|aryl hydrocarbon receptor complex|negative regulation of apoptotic process|protein-containing complex binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|sequence-specific double-stranded DNA binding" "hsa05200,hsa05202,hsa05211" Pathways in cancer|Transcriptional misregulation in cancer|Renal cell carcinoma ARNTL 231.0919976 263.2247123 198.9592829 0.755853359 -0.403821727 0.241676805 1 3.325714751 2.471688418 406 aryl hydrocarbon receptor nuclear translocator like "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006355,GO:0006357,GO:0007283,GO:0007623,GO:0016605,GO:0017162,GO:0032007,GO:0032922,GO:0033391,GO:0034751,GO:0042634,GO:0042753,GO:0043161,GO:0043231,GO:0043565,GO:0045599,GO:0045892,GO:0045893,GO:0045944,GO:0046983,GO:0050767,GO:0050796,GO:0051726,GO:0051775,GO:0051879,GO:0070888,GO:0090263,GO:0090403,GO:0120163,GO:0140297,GO:1901985,GO:1990837,GO:2000074,GO:2000323,GO:2000772,GO:2001016" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|spermatogenesis|circadian rhythm|PML body|aryl hydrocarbon receptor binding|negative regulation of TOR signaling|circadian regulation of gene expression|chromatoid body|aryl hydrocarbon receptor complex|regulation of hair cycle|positive regulation of circadian rhythm|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|sequence-specific DNA binding|negative regulation of fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|regulation of neurogenesis|regulation of insulin secretion|regulation of cell cycle|response to redox state|Hsp90 protein binding|E-box binding|positive regulation of canonical Wnt signaling pathway|oxidative stress-induced premature senescence|negative regulation of cold-induced thermogenesis|DNA-binding transcription factor binding|positive regulation of protein acetylation|sequence-specific double-stranded DNA binding|regulation of type B pancreatic cell development|negative regulation of glucocorticoid receptor signaling pathway|regulation of cellular senescence|positive regulation of skeletal muscle cell differentiation" "hsa04710,hsa04728" Circadian rhythm|Dopaminergic synapse bHLH ARNTL2 3719.016024 3023.442743 4414.589306 1.460120029 0.546086971 0.021829668 0.822216713 18.63228433 26.7501265 56938 aryl hydrocarbon receptor nuclear translocator like 2 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005737,GO:0006355,GO:0006357,GO:0007623,GO:0009649,GO:0034751,GO:0042753,GO:0045893,GO:0045944,GO:0046983,GO:0070888" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|circadian rhythm|entrainment of circadian clock|aryl hydrocarbon receptor complex|positive regulation of circadian rhythm|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|E-box binding" ARPC1A 4309.343306 3974.381032 4644.305579 1.168560725 0.224732706 0.346540578 1 134.0742169 154.0521391 10552 actin related protein 2/3 complex subunit 1A "GO:0003779,GO:0005634,GO:0005829,GO:0005885,GO:0015629,GO:0030036,GO:0034314,GO:0035861,GO:0038096,GO:0048013,GO:0051015,GO:0061024,GO:0070062" actin binding|nucleus|cytosol|Arp2/3 protein complex|actin cytoskeleton|actin cytoskeleton organization|Arp2/3 complex-mediated actin nucleation|site of double-strand break|Fc-gamma receptor signaling pathway involved in phagocytosis|ephrin receptor signaling pathway|actin filament binding|membrane organization|extracellular exosome "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ARPC1B 4058.997392 3886.986266 4231.008518 1.088506166 0.12234958 0.60798541 1 99.25421675 106.2309435 10095 actin related protein 2/3 complex subunit 1B "GO:0005200,GO:0005515,GO:0005634,GO:0005829,GO:0005885,GO:0005925,GO:0015629,GO:0032355,GO:0034314,GO:0036284,GO:0038096,GO:0043627,GO:0048013,GO:0051015,GO:0070062" structural constituent of cytoskeleton|protein binding|nucleus|cytosol|Arp2/3 protein complex|focal adhesion|actin cytoskeleton|response to estradiol|Arp2/3 complex-mediated actin nucleation|tubulobulbar complex|Fc-gamma receptor signaling pathway involved in phagocytosis|response to estrogen|ephrin receptor signaling pathway|actin filament binding|extracellular exosome "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ARPC2 7821.656079 7034.238261 8609.073898 1.223881475 0.291463849 0.236783754 1 245.8443796 295.8494892 10109 actin related protein 2/3 complex subunit 2 "GO:0005200,GO:0005515,GO:0005634,GO:0005654,GO:0005768,GO:0005829,GO:0005885,GO:0005925,GO:0010592,GO:0015629,GO:0030027,GO:0030041,GO:0034314,GO:0035861,GO:0036195,GO:0038096,GO:0043005,GO:0048013,GO:0051015,GO:0061024,GO:0070062,GO:0070358,GO:0098978,GO:1900026" structural constituent of cytoskeleton|protein binding|nucleus|nucleoplasm|endosome|cytosol|Arp2/3 protein complex|focal adhesion|positive regulation of lamellipodium assembly|actin cytoskeleton|lamellipodium|actin filament polymerization|Arp2/3 complex-mediated actin nucleation|site of double-strand break|muscle cell projection membrane|Fc-gamma receptor signaling pathway involved in phagocytosis|neuron projection|ephrin receptor signaling pathway|actin filament binding|membrane organization|extracellular exosome|actin polymerization-dependent cell motility|glutamatergic synapse|positive regulation of substrate adhesion-dependent cell spreading "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ARPC3 5514.171919 4820.237518 6208.10632 1.287925397 0.365049028 0.130251556 1 271.9315192 344.3669267 10094 actin related protein 2/3 complex subunit 3 "GO:0005200,GO:0005515,GO:0005634,GO:0005829,GO:0005885,GO:0005925,GO:0015629,GO:0016020,GO:0030027,GO:0031941,GO:0034314,GO:0035861,GO:0038096,GO:0048013,GO:0051015,GO:0061024,GO:0061850,GO:0070062,GO:0070358,GO:1990090" structural constituent of cytoskeleton|protein binding|nucleus|cytosol|Arp2/3 protein complex|focal adhesion|actin cytoskeleton|membrane|lamellipodium|filamentous actin|Arp2/3 complex-mediated actin nucleation|site of double-strand break|Fc-gamma receptor signaling pathway involved in phagocytosis|ephrin receptor signaling pathway|actin filament binding|membrane organization|growth cone leading edge|extracellular exosome|actin polymerization-dependent cell motility|cellular response to nerve growth factor stimulus "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ARPC4 1289.403464 1161.101893 1417.705035 1.220999676 0.288062817 0.231758798 1 41.98229947 50.40260111 10093 actin related protein 2/3 complex subunit 4 "GO:0005200,GO:0005515,GO:0005634,GO:0005829,GO:0005885,GO:0019899,GO:0030041,GO:0030674,GO:0034314,GO:0035861,GO:0038096,GO:0042995,GO:0045010,GO:0048013,GO:0051015,GO:0061024,GO:0070062" structural constituent of cytoskeleton|protein binding|nucleus|cytosol|Arp2/3 protein complex|enzyme binding|actin filament polymerization|protein-macromolecule adaptor activity|Arp2/3 complex-mediated actin nucleation|site of double-strand break|Fc-gamma receptor signaling pathway involved in phagocytosis|cell projection|actin nucleation|ephrin receptor signaling pathway|actin filament binding|membrane organization|extracellular exosome "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ARPC4-TTLL3 5.603389465 8.323311061 2.883467868 0.346432789 -1.529352609 0.352439314 1 0.111412043 0.03795092 100526693 ARPC4-TTLL3 readthrough ARPC5 5443.897479 4993.986637 5893.808322 1.180181036 0.239008181 0.321341473 1 36.63503618 42.51247947 10092 actin related protein 2/3 complex subunit 5 "GO:0005200,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005768,GO:0005829,GO:0005885,GO:0005925,GO:0014909,GO:0015629,GO:0016477,GO:0021769,GO:0030011,GO:0030027,GO:0030036,GO:0030426,GO:0034314,GO:0034774,GO:0035861,GO:0038096,GO:0043312,GO:0048013,GO:0051015,GO:0051639,GO:0061024,GO:0061842,GO:0070062,GO:0097581,GO:1904813" structural constituent of cytoskeleton|protein binding|extracellular region|nucleus|cytoplasm|endosome|cytosol|Arp2/3 protein complex|focal adhesion|smooth muscle cell migration|actin cytoskeleton|cell migration|orbitofrontal cortex development|maintenance of cell polarity|lamellipodium|actin cytoskeleton organization|growth cone|Arp2/3 complex-mediated actin nucleation|secretory granule lumen|site of double-strand break|Fc-gamma receptor signaling pathway involved in phagocytosis|neutrophil degranulation|ephrin receptor signaling pathway|actin filament binding|actin filament network formation|membrane organization|microtubule organizing center localization|extracellular exosome|lamellipodium organization|ficolin-1-rich granule lumen "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ARPC5L 1087.809162 1041.454297 1134.164028 1.089019491 0.123029776 0.616226248 1 18.19924744 19.48768546 81873 actin related protein 2/3 complex subunit 5 like "GO:0003674,GO:0005515,GO:0005737,GO:0005885,GO:0005925,GO:0008150,GO:0016477,GO:0034314,GO:0051015,GO:0070062,GO:0098978" molecular_function|protein binding|cytoplasm|Arp2/3 protein complex|focal adhesion|biological_process|cell migration|Arp2/3 complex-mediated actin nucleation|actin filament binding|extracellular exosome|glutamatergic synapse "hsa04144,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection ARPIN 1683.469304 1678.187593 1688.751015 1.006294542 0.009052643 0.972385883 1 10.89161954 10.77677357 348110 actin related protein 2/3 complex inhibitor "GO:0005515,GO:0030027,GO:0030336,GO:0033058,GO:0051126,GO:2000393" protein binding|lamellipodium|negative regulation of cell migration|directional locomotion|negative regulation of actin nucleation|negative regulation of lamellipodium morphogenesis ARPP19 3784.08851 3634.165692 3934.011328 1.08250742 0.114376914 0.631007679 1 31.35285219 33.37176031 10776 cAMP regulated phosphoprotein 19 "GO:0000086,GO:0000278,GO:0004864,GO:0005102,GO:0005515,GO:0005654,GO:0005737,GO:0015459,GO:0019212,GO:0019888,GO:0032515,GO:0035308,GO:0045722,GO:0046326,GO:0051301,GO:0051721" G2/M transition of mitotic cell cycle|mitotic cell cycle|protein phosphatase inhibitor activity|signaling receptor binding|protein binding|nucleoplasm|cytoplasm|potassium channel regulator activity|phosphatase inhibitor activity|protein phosphatase regulator activity|negative regulation of phosphoprotein phosphatase activity|negative regulation of protein dephosphorylation|positive regulation of gluconeogenesis|positive regulation of glucose import|cell division|protein phosphatase 2A binding ARPP21 11.48921209 11.44455271 11.53387147 1.007804478 0.011215772 1 1 0.031337852 0.031053939 10777 cAMP regulated phosphoprotein 21 "GO:0003674,GO:0003676,GO:0005516,GO:0005575,GO:0005737,GO:0008150,GO:0034605" molecular_function|nucleic acid binding|calmodulin binding|cellular_component|cytoplasm|biological_process|cellular response to heat ARRB1 156.2363039 177.9107739 134.5618338 0.756344491 -0.402884608 0.315301601 1 1.233087145 0.917032225 408 arrestin beta 1 "GO:0000139,GO:0000187,GO:0000785,GO:0001664,GO:0001933,GO:0001934,GO:0002031,GO:0002092,GO:0003713,GO:0004402,GO:0004857,GO:0005096,GO:0005159,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005765,GO:0005768,GO:0005829,GO:0005886,GO:0005905,GO:0006357,GO:0006511,GO:0007186,GO:0008134,GO:0008284,GO:0014069,GO:0015031,GO:0016323,GO:0016567,GO:0016573,GO:0016604,GO:0030168,GO:0030331,GO:0030659,GO:0031143,GO:0031397,GO:0031398,GO:0031410,GO:0031625,GO:0031691,GO:0031692,GO:0031701,GO:0031762,GO:0031896,GO:0032088,GO:0032715,GO:0032717,GO:0034260,GO:0034393,GO:0035025,GO:0035066,GO:0035612,GO:0035615,GO:0042493,GO:0042699,GO:0043149,GO:0043161,GO:0043197,GO:0043280,GO:0043524,GO:0043547,GO:0044325,GO:0045211,GO:0045309,GO:0045746,GO:0045944,GO:0061024,GO:0070373,GO:0070374,GO:0090240,GO:1990763" Golgi membrane|activation of MAPK activity|chromatin|G protein-coupled receptor binding|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|G protein-coupled receptor internalization|positive regulation of receptor internalization|transcription coactivator activity|histone acetyltransferase activity|enzyme inhibitor activity|GTPase activator activity|insulin-like growth factor receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|lysosomal membrane|endosome|cytosol|plasma membrane|clathrin-coated pit|regulation of transcription by RNA polymerase II|ubiquitin-dependent protein catabolic process|G protein-coupled receptor signaling pathway|transcription factor binding|positive regulation of cell population proliferation|postsynaptic density|protein transport|basolateral plasma membrane|protein ubiquitination|histone acetylation|nuclear body|platelet activation|estrogen receptor binding|cytoplasmic vesicle membrane|pseudopodium|negative regulation of protein ubiquitination|positive regulation of protein ubiquitination|cytoplasmic vesicle|ubiquitin protein ligase binding|alpha-1A adrenergic receptor binding|alpha-1B adrenergic receptor binding|angiotensin receptor binding|follicle-stimulating hormone receptor binding|V2 vasopressin receptor binding|negative regulation of NF-kappaB transcription factor activity|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of GTPase activity|positive regulation of smooth muscle cell apoptotic process|positive regulation of Rho protein signal transduction|positive regulation of histone acetylation|AP-2 adaptor complex binding|clathrin adaptor activity|response to drug|follicle-stimulating hormone signaling pathway|stress fiber assembly|proteasome-mediated ubiquitin-dependent protein catabolic process|dendritic spine|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of neuron apoptotic process|positive regulation of GTPase activity|ion channel binding|postsynaptic membrane|protein phosphorylated amino acid binding|negative regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|membrane organization|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of histone H4 acetylation|arrestin family protein binding "hsa04010,hsa04062,hsa04144,hsa04340,hsa04728,hsa04740,hsa04926,hsa04928,hsa04929,hsa05032" "MAPK signaling pathway|Chemokine signaling pathway|Endocytosis|Hedgehog signaling pathway|Dopaminergic synapse|Olfactory transduction|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Morphine addiction" other ARRB2 894.7117787 905.1600779 884.2634795 0.97691392 -0.03369665 0.896629117 1 22.78619328 21.88765593 409 arrestin beta 2 "GO:0001664,GO:0001933,GO:0002031,GO:0002032,GO:0002092,GO:0005102,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005829,GO:0005886,GO:0005905,GO:0006366,GO:0007179,GO:0007186,GO:0007212,GO:0007420,GO:0007628,GO:0010628,GO:0014069,GO:0015031,GO:0016323,GO:0016567,GO:0016579,GO:0019899,GO:0019904,GO:0030139,GO:0030168,GO:0031397,GO:0031410,GO:0031623,GO:0031625,GO:0031691,GO:0031692,GO:0031701,GO:0031702,GO:0031748,GO:0031762,GO:0031826,GO:0031859,GO:0032088,GO:0032226,GO:0032691,GO:0032695,GO:0032715,GO:0032720,GO:0032967,GO:0033138,GO:0034122,GO:0034260,GO:0034392,GO:0042699,GO:0042802,GO:0043154,GO:0043161,GO:0043197,GO:0043422,GO:0043524,GO:0044877,GO:0045211,GO:0045953,GO:0050731,GO:0050965,GO:0051019,GO:0051897,GO:0051898,GO:0051928,GO:0060071,GO:0060079,GO:0060326,GO:0061024,GO:0070374,GO:0071889,GO:0090201,GO:1904037,GO:1990763,GO:2000573,GO:2000727" "G protein-coupled receptor binding|negative regulation of protein phosphorylation|G protein-coupled receptor internalization|desensitization of G protein-coupled receptor signaling pathway by arrestin|positive regulation of receptor internalization|signaling receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|endosome|cytosol|plasma membrane|clathrin-coated pit|transcription by RNA polymerase II|transforming growth factor beta receptor signaling pathway|G protein-coupled receptor signaling pathway|dopamine receptor signaling pathway|brain development|adult walking behavior|positive regulation of gene expression|postsynaptic density|protein transport|basolateral plasma membrane|protein ubiquitination|protein deubiquitination|enzyme binding|protein domain specific binding|endocytic vesicle|platelet activation|negative regulation of protein ubiquitination|cytoplasmic vesicle|receptor internalization|ubiquitin protein ligase binding|alpha-1A adrenergic receptor binding|alpha-1B adrenergic receptor binding|angiotensin receptor binding|type 1 angiotensin receptor binding|D1 dopamine receptor binding|follicle-stimulating hormone receptor binding|type 2A serotonin receptor binding|platelet activating factor receptor binding|negative regulation of NF-kappaB transcription factor activity|positive regulation of synaptic transmission, dopaminergic|negative regulation of interleukin-1 beta production|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|positive regulation of collagen biosynthetic process|positive regulation of peptidyl-serine phosphorylation|negative regulation of toll-like receptor signaling pathway|negative regulation of GTPase activity|negative regulation of smooth muscle cell apoptotic process|follicle-stimulating hormone signaling pathway|identical protein binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|dendritic spine|protein kinase B binding|negative regulation of neuron apoptotic process|protein-containing complex binding|postsynaptic membrane|negative regulation of natural killer cell mediated cytotoxicity|positive regulation of peptidyl-tyrosine phosphorylation|detection of temperature stimulus involved in sensory perception of pain|mitogen-activated protein kinase binding|positive regulation of protein kinase B signaling|negative regulation of protein kinase B signaling|positive regulation of calcium ion transport|Wnt signaling pathway, planar cell polarity pathway|excitatory postsynaptic potential|cell chemotaxis|membrane organization|positive regulation of ERK1 and ERK2 cascade|14-3-3 protein binding|negative regulation of release of cytochrome c from mitochondria|positive regulation of epithelial cell apoptotic process|arrestin family protein binding|positive regulation of DNA biosynthetic process|positive regulation of cardiac muscle cell differentiation" "hsa04010,hsa04062,hsa04144,hsa04340,hsa04728,hsa04740,hsa04926,hsa04928,hsa04929,hsa05032" "MAPK signaling pathway|Chemokine signaling pathway|Endocytosis|Hedgehog signaling pathway|Dopaminergic synapse|Olfactory transduction|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Morphine addiction" ARRDC1 599.9262069 584.712602 615.1398118 1.05203789 0.073186665 0.786127786 1 7.363151702 7.616690493 92714 arrestin domain containing 1 "GO:0005515,GO:0005737,GO:0005886,GO:0006511,GO:0006858,GO:0015031,GO:0016567,GO:0031410,GO:0031625,GO:0042802,GO:0045746,GO:0070062,GO:0140112,GO:1903561,GO:1990756,GO:1990763" protein binding|cytoplasm|plasma membrane|ubiquitin-dependent protein catabolic process|extracellular transport|protein transport|protein ubiquitination|cytoplasmic vesicle|ubiquitin protein ligase binding|identical protein binding|negative regulation of Notch signaling pathway|extracellular exosome|extracellular vesicle biogenesis|extracellular vesicle|ubiquitin ligase-substrate adaptor activity|arrestin family protein binding ARRDC2 280.4921497 311.0837509 249.9005486 0.80332241 -0.315948971 0.328961726 1 5.625878698 4.44376849 27106 arrestin domain containing 2 "GO:0005515,GO:0005737,GO:0005886,GO:0015031,GO:0031410" protein binding|cytoplasm|plasma membrane|protein transport|cytoplasmic vesicle ARRDC3 1266.905003 1239.132934 1294.677073 1.044825004 0.063261328 0.795768227 1 13.52633407 13.89616125 57561 arrestin domain containing 3 "GO:0001659,GO:0005515,GO:0005737,GO:0005764,GO:0005768,GO:0005769,GO:0005886,GO:0015031,GO:0031651,GO:0031699,GO:0043588,GO:0051443,GO:0060613,GO:0071878,GO:0090327,GO:0120163" temperature homeostasis|protein binding|cytoplasm|lysosome|endosome|early endosome|plasma membrane|protein transport|negative regulation of heat generation|beta-3 adrenergic receptor binding|skin development|positive regulation of ubiquitin-protein transferase activity|fat pad development|negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway|negative regulation of locomotion involved in locomotory behavior|negative regulation of cold-induced thermogenesis ARRDC4 119.7966659 167.5066351 72.0866967 0.430351291 -1.216413298 0.005958021 0.464919713 2.200768403 0.931255029 91947 arrestin domain containing 4 "GO:0005515,GO:0005737,GO:0005768,GO:0005769,GO:0005886,GO:0015031,GO:0016567,GO:0043231,GO:0051443,GO:0140112,GO:1903561,GO:1990756" protein binding|cytoplasm|endosome|early endosome|plasma membrane|protein transport|protein ubiquitination|intracellular membrane-bounded organelle|positive regulation of ubiquitin-protein transferase activity|extracellular vesicle biogenesis|extracellular vesicle|ubiquitin ligase-substrate adaptor activity ARSA 455.1841456 405.7614142 504.6068769 1.243604885 0.314528189 0.261353799 1 5.043023037 6.166582555 410 arylsulfatase A "GO:0004065,GO:0004098,GO:0005509,GO:0005515,GO:0005576,GO:0005764,GO:0005788,GO:0006687,GO:0008484,GO:0035578,GO:0043202,GO:0043312,GO:0070062" arylsulfatase activity|cerebroside-sulfatase activity|calcium ion binding|protein binding|extracellular region|lysosome|endoplasmic reticulum lumen|glycosphingolipid metabolic process|sulfuric ester hydrolase activity|azurophil granule lumen|lysosomal lumen|neutrophil degranulation|extracellular exosome "hsa00600,hsa04142" Sphingolipid metabolism|Lysosome ARSB 289.5639951 259.0630568 320.0649333 1.235471153 0.305061325 0.341613933 1 1.033775924 1.255828114 411 arylsulfatase B "GO:0003943,GO:0004065,GO:0005576,GO:0005739,GO:0005764,GO:0005788,GO:0005791,GO:0005794,GO:0006914,GO:0007040,GO:0007041,GO:0007417,GO:0007584,GO:0009268,GO:0009986,GO:0010632,GO:0010976,GO:0030207,GO:0035578,GO:0043202,GO:0043312,GO:0043627,GO:0046872,GO:0051597,GO:0061580,GO:0070062,GO:1904813" N-acetylgalactosamine-4-sulfatase activity|arylsulfatase activity|extracellular region|mitochondrion|lysosome|endoplasmic reticulum lumen|rough endoplasmic reticulum|Golgi apparatus|autophagy|lysosome organization|lysosomal transport|central nervous system development|response to nutrient|response to pH|cell surface|regulation of epithelial cell migration|positive regulation of neuron projection development|chondroitin sulfate catabolic process|azurophil granule lumen|lysosomal lumen|neutrophil degranulation|response to estrogen|metal ion binding|response to methylmercury|colon epithelial cell migration|extracellular exosome|ficolin-1-rich granule lumen "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome ARSD 160.8489693 160.2237379 161.4742006 1.007804478 0.011215772 0.99545689 1 1.365295611 1.352926354 414 arylsulfatase D "GO:0004065,GO:0005764,GO:0005788,GO:0046872" arylsulfatase activity|lysosome|endoplasmic reticulum lumen|metal ion binding ARSG 121.079884 163.3449796 78.81478839 0.482505116 -1.051383854 0.016608404 0.767297059 1.309315312 0.621179834 22901 arylsulfatase G "GO:0004065,GO:0005615,GO:0005764,GO:0005783,GO:0005788,GO:0006790,GO:0046872" arylsulfatase activity|extracellular space|lysosome|endoplasmic reticulum|endoplasmic reticulum lumen|sulfur compound metabolic process|metal ion binding hsa04142 Lysosome ARSI 103.0858771 94.67766332 111.4940909 1.177617687 0.235871245 0.622759955 1 1.623120103 1.879430001 340075 arylsulfatase family member I "GO:0004065,GO:0005515,GO:0005576,GO:0005788,GO:0046872" arylsulfatase activity|protein binding|extracellular region|endoplasmic reticulum lumen|metal ion binding ARSJ 664.3683154 573.2680493 755.4685814 1.317827816 0.398161884 0.123248674 1 5.038580726 6.528870731 79642 arylsulfatase family member J "GO:0004065,GO:0005576,GO:0005788,GO:0015629,GO:0046872" arylsulfatase activity|extracellular region|endoplasmic reticulum lumen|actin cytoskeleton|metal ion binding ARSK 316.466301 284.03299 348.899612 1.22837707 0.296753487 0.339604238 1 4.523520932 5.463607391 153642 arylsulfatase family member K "GO:0004065,GO:0005576,GO:0005788,GO:0046872" arylsulfatase activity|extracellular region|endoplasmic reticulum lumen|metal ion binding ARSL 5.083182523 7.282897178 2.883467868 0.395923188 -1.336707531 0.4551609 1 0.138614421 0.05396231 415 arylsulfatase L "GO:0001501,GO:0004065,GO:0005788,GO:0005794,GO:0005795,GO:0046872,GO:0070062" skeletal system development|arylsulfatase activity|endoplasmic reticulum lumen|Golgi apparatus|Golgi stack|metal ion binding|extracellular exosome ARTN 45.59515727 48.89945248 42.29086206 0.864853488 -0.209472343 0.763360131 1 1.783782574 1.516895409 9048 artemin "GO:0000165,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0007165,GO:0007405,GO:0007411,GO:0007422,GO:0008083,GO:0030116,GO:0030971,GO:0050930,GO:0061146,GO:0097021" MAPK cascade|signaling receptor binding|protein binding|extracellular region|extracellular space|signal transduction|neuroblast proliferation|axon guidance|peripheral nervous system development|growth factor activity|glial cell-derived neurotrophic factor receptor binding|receptor tyrosine kinase binding|induction of positive chemotaxis|Peyer's patch morphogenesis|lymphocyte migration into lymphoid organs ARV1 242.4478459 208.0827765 276.8129153 1.330301911 0.411753702 0.224861475 1 7.104923444 9.293531951 64801 "ARV1 homolog, fatty acid homeostasis modulator" "GO:0005515,GO:0005789,GO:0005794,GO:0006665,GO:0006695,GO:0015248,GO:0016021,GO:0016125,GO:0032366,GO:0032383,GO:0032541,GO:0090181,GO:0097036" protein binding|endoplasmic reticulum membrane|Golgi apparatus|sphingolipid metabolic process|cholesterol biosynthetic process|sterol transporter activity|integral component of membrane|sterol metabolic process|intracellular sterol transport|regulation of intracellular cholesterol transport|cortical endoplasmic reticulum|regulation of cholesterol metabolic process|regulation of plasma membrane sterol distribution ARVCF 318.606265 340.2153396 296.9971904 0.872968252 -0.195998908 0.530098328 1 2.018977803 1.733010415 421 ARVCF delta catenin family member "GO:0005515,GO:0005622,GO:0005634,GO:0005737,GO:0005886,GO:0005912,GO:0007043,GO:0007155,GO:0007275,GO:0016339,GO:0045296,GO:0098609" protein binding|intracellular anatomical structure|nucleus|cytoplasm|plasma membrane|adherens junction|cell-cell junction assembly|cell adhesion|multicellular organism development|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|cadherin binding|cell-cell adhesion ASAH1 1379.34393 1478.428127 1280.259733 0.865960076 -0.207627582 0.386942021 1 24.46542385 20.83155993 427 N-acylsphingosine amidohydrolase 1 "GO:0005576,GO:0005615,GO:0005634,GO:0005764,GO:0005769,GO:0005783,GO:0006631,GO:0006687,GO:0016810,GO:0016811,GO:0017040,GO:0017064,GO:0030216,GO:0043202,GO:0043312,GO:0046512,GO:0046513,GO:0046514,GO:0050810,GO:0062098,GO:0070062,GO:0071356,GO:0102121,GO:1904724,GO:1904813" "extracellular region|extracellular space|nucleus|lysosome|early endosome|endoplasmic reticulum|fatty acid metabolic process|glycosphingolipid metabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|N-acylsphingosine amidohydrolase activity|fatty acid amide hydrolase activity|keratinocyte differentiation|lysosomal lumen|neutrophil degranulation|sphingosine biosynthetic process|ceramide biosynthetic process|ceramide catabolic process|regulation of steroid biosynthetic process|regulation of programmed necrotic cell death|extracellular exosome|cellular response to tumor necrosis factor|ceramidase activity|tertiary granule lumen|ficolin-1-rich granule lumen" "hsa00600,hsa04071,hsa04142" Sphingolipid metabolism|Sphingolipid signaling pathway|Lysosome ASAH2 108.2432871 116.5263549 99.96021942 0.857833574 -0.221230314 0.639004588 1 1.234133239 1.040965335 56624 N-acylsphingosine amidohydrolase 2 "GO:0000139,GO:0005509,GO:0005576,GO:0005739,GO:0005794,GO:0005886,GO:0005887,GO:0005901,GO:0006670,GO:0006672,GO:0006915,GO:0007346,GO:0008270,GO:0017040,GO:0042759,GO:0044241,GO:0045121,GO:0046512,GO:0046513,GO:0046514,GO:0070062,GO:0070774,GO:0071345,GO:0071633,GO:0102121,GO:2001234" Golgi membrane|calcium ion binding|extracellular region|mitochondrion|Golgi apparatus|plasma membrane|integral component of plasma membrane|caveola|sphingosine metabolic process|ceramide metabolic process|apoptotic process|regulation of mitotic cell cycle|zinc ion binding|N-acylsphingosine amidohydrolase activity|long-chain fatty acid biosynthetic process|lipid digestion|membrane raft|sphingosine biosynthetic process|ceramide biosynthetic process|ceramide catabolic process|extracellular exosome|phytoceramidase activity|cellular response to cytokine stimulus|dihydroceramidase activity|ceramidase activity|negative regulation of apoptotic signaling pathway "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway ASAH2B 272.2134981 282.9925761 261.43442 0.923820772 -0.11431511 0.734104693 1 2.8965849 2.631147312 653308 N-acylsphingosine amidohydrolase 2B "GO:0005576,GO:0017040,GO:0042759,GO:0046512,GO:0046514" extracellular region|N-acylsphingosine amidohydrolase activity|long-chain fatty acid biosynthetic process|sphingosine biosynthetic process|ceramide catabolic process ASAP1 4707.707352 4856.652004 4558.762699 0.93866365 -0.091319803 0.70340755 1 37.94884207 35.02512611 50807 "ArfGAP with SH3 domain, ankyrin repeat and PH domain 1" "GO:0001786,GO:0002102,GO:0005096,GO:0005515,GO:0005546,GO:0005547,GO:0005829,GO:0031253,GO:0043197,GO:0043547,GO:0045296,GO:0046872,GO:0060271,GO:0061000,GO:0071803,GO:1903527" "phosphatidylserine binding|podosome|GTPase activator activity|protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytosol|cell projection membrane|dendritic spine|positive regulation of GTPase activity|cadherin binding|metal ion binding|cilium assembly|negative regulation of dendritic spine development|positive regulation of podosome assembly|positive regulation of membrane tubulation" "hsa04144,hsa04666" Endocytosis|Fc gamma R-mediated phagocytosis ASAP2 2628.726058 2572.943532 2684.508585 1.043360864 0.061238224 0.796911754 1 18.91888501 19.40891502 8853 "ArfGAP with SH3 domain, ankyrin repeat and PH domain 2" "GO:0005096,GO:0005515,GO:0005886,GO:0032580,GO:0043547,GO:0046872" GTPase activator activity|protein binding|plasma membrane|Golgi cisterna membrane|positive regulation of GTPase activity|metal ion binding "hsa04144,hsa04666" Endocytosis|Fc gamma R-mediated phagocytosis ASAP3 331.7108181 318.3666481 345.0549882 1.083828945 0.116137081 0.710749695 1 3.969776373 4.230561046 55616 "ArfGAP with SH3 domain, ankyrin repeat and PH domain 3" "GO:0001726,GO:0005096,GO:0005515,GO:0005654,GO:0005829,GO:0005925,GO:0016477,GO:0043231,GO:0043547,GO:0046872,GO:0051492" ruffle|GTPase activator activity|protein binding|nucleoplasm|cytosol|focal adhesion|cell migration|intracellular membrane-bounded organelle|positive regulation of GTPase activity|metal ion binding|regulation of stress fiber assembly "hsa04144,hsa04666" Endocytosis|Fc gamma R-mediated phagocytosis ASB1 5164.837003 4707.872819 5621.801187 1.194127667 0.255957087 0.287054131 1 36.46067619 42.81014099 51665 ankyrin repeat and SOCS box containing 1 "GO:0000151,GO:0001818,GO:0005515,GO:0005829,GO:0016567,GO:0030539,GO:0035556,GO:0043687,GO:0061630" ubiquitin ligase complex|negative regulation of cytokine production|protein binding|cytosol|protein ubiquitination|male genitalia development|intracellular signal transduction|post-translational protein modification|ubiquitin protein ligase activity ASB12 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.175295901 0.079616057 142689 ankyrin repeat and SOCS box containing 12 "GO:0000151,GO:0005515,GO:0005829,GO:0016567,GO:0043687,GO:0061630" ubiquitin ligase complex|protein binding|cytosol|protein ubiquitination|post-translational protein modification|ubiquitin protein ligase activity ASB13 393.0656691 415.1251392 371.006199 0.893721348 -0.162103009 0.581428396 1 8.15401756 7.165474469 79754 ankyrin repeat and SOCS box containing 13 "GO:0005515,GO:0005829,GO:0016567,GO:0035556,GO:0043687" protein binding|cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification ASB2 31.09856001 46.81862472 15.3784953 0.328469608 -1.606168206 0.027005662 0.873268385 0.813354151 0.262691523 51676 ankyrin repeat and SOCS box containing 2 "GO:0000151,GO:0005515,GO:0005829,GO:0006511,GO:0007165,GO:0016567,GO:0035556,GO:0035914,GO:0043687,GO:0061630" ubiquitin ligase complex|protein binding|cytosol|ubiquitin-dependent protein catabolic process|signal transduction|protein ubiquitination|intracellular signal transduction|skeletal muscle cell differentiation|post-translational protein modification|ubiquitin protein ligase activity ASB3 12.45036805 11.44455271 13.45618338 1.175771891 0.233608194 0.899941244 1 0.221134954 0.255653444 51130 ankyrin repeat and SOCS box containing 3 "GO:0005515,GO:0005829,GO:0016567,GO:0030315,GO:0035556,GO:0036371,GO:0043687,GO:0055117" protein binding|cytosol|protein ubiquitination|T-tubule|intracellular signal transduction|protein localization to T-tubule|post-translational protein modification|regulation of cardiac muscle contraction ASB6 646.4724593 658.5819877 634.362931 0.963225449 -0.054054585 0.840456029 1 7.635739792 7.231863949 140459 ankyrin repeat and SOCS box containing 6 "GO:0005515,GO:0005829,GO:0016567,GO:0035556,GO:0043687" protein binding|cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification ASB7 732.2229307 739.7342706 724.7115908 0.979691789 -0.029600146 0.912942136 1 7.751474268 7.466979454 140460 ankyrin repeat and SOCS box containing 7 "GO:0005515,GO:0005829,GO:0016567,GO:0035556,GO:0043687" protein binding|cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification ASB8 359.4849613 366.2256867 352.7442358 0.963188134 -0.054110476 0.864888533 1 6.918510373 6.552316976 140461 ankyrin repeat and SOCS box containing 8 "GO:0005515,GO:0005829,GO:0016567,GO:0035556,GO:0043687" protein binding|cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification ASB9 20.81330807 29.13158871 12.49502743 0.428916787 -1.221230314 0.14774721 1 0.766995238 0.323472146 140462 ankyrin repeat and SOCS box containing 9 "GO:0005515,GO:0005739,GO:0005829,GO:0016567,GO:0035556,GO:0043687,GO:0045732" protein binding|mitochondrion|cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification|positive regulation of protein catabolic process ASCC1 1237.832551 1232.890451 1242.774651 1.008017095 0.011520106 0.965658257 1 12.78109895 12.66797721 51008 activating signal cointegrator 1 complex subunit 1 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006307,GO:0006355,GO:0016607,GO:0031594" "RNA binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|DNA dealkylation involved in DNA repair|regulation of transcription, DNA-templated|nuclear speck|neuromuscular junction" ASCC2 1094.402661 1176.708101 1012.097222 0.860108994 -0.217408603 0.373365506 1 19.40029307 16.40714282 84164 activating signal cointegrator 1 complex subunit 2 "GO:0005515,GO:0005634,GO:0005654,GO:0006307,GO:0006355,GO:0016607,GO:0043130,GO:0099053" "protein binding|nucleus|nucleoplasm|DNA dealkylation involved in DNA repair|regulation of transcription, DNA-templated|nuclear speck|ubiquitin binding|activating signal cointegrator 1 complex" ASCC3 1405.944296 1457.61985 1354.268742 0.92909598 -0.106100454 0.659447229 1 6.524953228 5.9608633 10973 activating signal cointegrator 1 complex subunit 3 "GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006307,GO:0008283,GO:0016020,GO:0016607,GO:0032508,GO:0043138,GO:0099053" RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|DNA dealkylation involved in DNA repair|cell population proliferation|membrane|nuclear speck|DNA duplex unwinding|3'-5' DNA helicase activity|activating signal cointegrator 1 complex ASF1A 467.3319588 472.3479027 462.3160148 0.978761655 -0.030970513 0.919228155 1 10.35675408 9.967168244 25842 anti-silencing function 1A histone chaperone "GO:0000785,GO:0001649,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006334,GO:0006335,GO:0006336,GO:0031936,GO:0032991,GO:0042393,GO:0042692" chromatin|osteoblast differentiation|chromatin binding|protein binding|nucleus|nucleoplasm|DNA repair|nucleosome assembly|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|negative regulation of chromatin silencing|protein-containing complex|histone binding|muscle cell differentiation ASF1B 1480.716316 1452.41778 1509.014851 1.038967487 0.055150508 0.819806927 1 45.89275755 46.88320462 55723 anti-silencing function 1B histone chaperone "GO:0000785,GO:0001835,GO:0005515,GO:0005654,GO:0006335,GO:0006336,GO:0007283,GO:0030154,GO:0032991,GO:0042393" chromatin|blastocyst hatching|protein binding|nucleoplasm|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|spermatogenesis|cell differentiation|protein-containing complex|histone binding ASGR1 52.36287793 49.93986637 54.78588949 1.097037166 0.133612404 0.85113829 1 2.034502964 2.194577118 432 asialoglycoprotein receptor 1 "GO:0004873,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0006898,GO:0016032,GO:0018279,GO:0030246,GO:0031668,GO:0046872" asialoglycoprotein receptor activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|receptor-mediated endocytosis|viral process|protein N-linked glycosylation via asparagine|carbohydrate binding|cellular response to extracellular stimulus|metal ion binding hsa04918 Thyroid hormone synthesis ASH1L 1586.975697 1920.604027 1253.347367 0.652579787 -0.615773793 0.009808273 0.604180798 8.450746724 5.422504012 55870 ASH1 like histone lysine methyltransferase "GO:0001501,GO:0002674,GO:0003677,GO:0003682,GO:0005634,GO:0005654,GO:0005694,GO:0005794,GO:0005923,GO:0007338,GO:0009791,GO:0030317,GO:0042800,GO:0043124,GO:0043409,GO:0045944,GO:0046697,GO:0046872,GO:0046974,GO:0046975,GO:0051567,GO:0051568,GO:0061038,GO:0097676,GO:1903699,GO:1903709" skeletal system development|negative regulation of acute inflammatory response|DNA binding|chromatin binding|nucleus|nucleoplasm|chromosome|Golgi apparatus|bicellular tight junction|single fertilization|post-embryonic development|flagellated sperm motility|histone methyltransferase activity (H3-K4 specific)|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of MAPK cascade|positive regulation of transcription by RNA polymerase II|decidualization|metal ion binding|histone methyltransferase activity (H3-K9 specific)|histone methyltransferase activity (H3-K36 specific)|histone H3-K9 methylation|histone H3-K4 methylation|uterus morphogenesis|histone H3-K36 dimethylation|tarsal gland development|uterine gland development hsa00310 Lysine degradation ASH2L 964.8711331 917.6450445 1012.097222 1.102928881 0.141339766 0.568610226 1 14.11326498 15.30545282 9070 "ASH2 like, histone lysine methyltransferase complex subunit" "GO:0000976,GO:0005515,GO:0005634,GO:0005654,GO:0006974,GO:0008013,GO:0008284,GO:0030097,GO:0035097,GO:0042800,GO:0043627,GO:0044666,GO:0045652,GO:0046872,GO:0048188,GO:0051568,GO:1904837" transcription regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|cellular response to DNA damage stimulus|beta-catenin binding|positive regulation of cell population proliferation|hemopoiesis|histone methyltransferase complex|histone methyltransferase activity (H3-K4 specific)|response to estrogen|MLL3/4 complex|regulation of megakaryocyte differentiation|metal ion binding|Set1C/COMPASS complex|histone H3-K4 methylation|beta-catenin-TCF complex assembly hsa04934 Cushing syndrome ASIC1 367.7441057 343.3365813 392.15163 1.142178409 0.191788018 0.521166639 1 3.937941611 4.422566758 41 acid sensing ion channel subunit 1 "GO:0001662,GO:0001975,GO:0005515,GO:0005794,GO:0005886,GO:0005887,GO:0006814,GO:0007165,GO:0007613,GO:0008306,GO:0009268,GO:0009986,GO:0010447,GO:0015280,GO:0022839,GO:0034220,GO:0035725,GO:0042391,GO:0044736,GO:0045202,GO:0046929,GO:0050915,GO:0070207,GO:0070588,GO:0071467" behavioral fear response|response to amphetamine|protein binding|Golgi apparatus|plasma membrane|integral component of plasma membrane|sodium ion transport|signal transduction|memory|associative learning|response to pH|cell surface|response to acidic pH|ligand-gated sodium channel activity|ion gated channel activity|ion transmembrane transport|sodium ion transmembrane transport|regulation of membrane potential|acid-sensing ion channel activity|synapse|negative regulation of neurotransmitter secretion|sensory perception of sour taste|protein homotrimerization|calcium ion transmembrane transport|cellular response to pH hsa04750 Inflammatory mediator regulation of TRP channels ASIC3 17.73169539 23.9295193 11.53387147 0.481993446 -1.052914565 0.24504821 1 0.551890434 0.261556296 9311 acid sensing ion channel subunit 3 "GO:0005261,GO:0005272,GO:0005886,GO:0005887,GO:0007165,GO:0007600,GO:0009408,GO:0010447,GO:0015280,GO:0034220,GO:0035725,GO:0042930,GO:0042931,GO:0044736,GO:0048471,GO:0050915,GO:0050965,GO:0050966,GO:0050968" cation channel activity|sodium channel activity|plasma membrane|integral component of plasma membrane|signal transduction|sensory perception|response to heat|response to acidic pH|ligand-gated sodium channel activity|ion transmembrane transport|sodium ion transmembrane transport|enterobactin transport|enterobactin transmembrane transporter activity|acid-sensing ion channel activity|perinuclear region of cytoplasm|sensory perception of sour taste|detection of temperature stimulus involved in sensory perception of pain|detection of mechanical stimulus involved in sensory perception of pain|detection of chemical stimulus involved in sensory perception of pain hsa04750 Inflammatory mediator regulation of TRP channels ASL 396.390086 414.0847253 378.6954467 0.914536141 -0.128887911 0.662212788 1 10.32660782 9.286022575 435 argininosuccinate lyase "GO:0000050,GO:0004056,GO:0005515,GO:0005829,GO:0042450,GO:0042802,GO:0070062" urea cycle|argininosuccinate lyase activity|protein binding|cytosol|arginine biosynthetic process via ornithine|identical protein binding|extracellular exosome "hsa00220,hsa00250" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism" ASMTL-2 132.5395279 148.7791852 116.2998707 0.781694499 -0.355323209 0.406586734 1 3.148323422 2.419845145 8623 acetylserotonin O-methyltransferase like ASNS 2705.450074 3388.628016 2022.272131 0.596781978 -0.744724125 0.001707252 0.264245783 56.6556545 33.24529106 440 asparagine synthetase (glutamine-hydrolyzing) "GO:0001889,GO:0004066,GO:0005515,GO:0005524,GO:0005829,GO:0006529,GO:0006541,GO:0008652,GO:0009416,GO:0009612,GO:0009636,GO:0031427,GO:0032354,GO:0032870,GO:0036499,GO:0042149,GO:0042802,GO:0043066,GO:0043200,GO:0045931,GO:0070981" liver development|asparagine synthase (glutamine-hydrolyzing) activity|protein binding|ATP binding|cytosol|asparagine biosynthetic process|glutamine metabolic process|cellular amino acid biosynthetic process|response to light stimulus|response to mechanical stimulus|response to toxic substance|response to methotrexate|response to follicle-stimulating hormone|cellular response to hormone stimulus|PERK-mediated unfolded protein response|cellular response to glucose starvation|identical protein binding|negative regulation of apoptotic process|response to amino acid|positive regulation of mitotic cell cycle|L-asparagine biosynthetic process hsa00250 "Alanine, aspartate and glutamate metabolism" ASNSD1 765.3633039 688.7539903 841.9726175 1.222457698 0.289784543 0.252530414 1 15.245763 18.32543036 54529 asparagine synthetase domain containing 1 "GO:0003674,GO:0004066,GO:0005575,GO:0006529,GO:0006541,GO:0008150" molecular_function|asparagine synthase (glutamine-hydrolyzing) activity|cellular_component|asparagine biosynthetic process|glutamine metabolic process|biological_process ASPA 18.57899487 8.323311061 28.83467868 3.464327894 1.792575486 0.047443826 1 0.077670889 0.264574781 443 aspartoacylase "GO:0004046,GO:0005515,GO:0005634,GO:0005829,GO:0006533,GO:0008652,GO:0016788,GO:0016811,GO:0019807,GO:0022010,GO:0042802,GO:0046872,GO:0048714" "aminoacylase activity|protein binding|nucleus|cytosol|aspartate catabolic process|cellular amino acid biosynthetic process|hydrolase activity, acting on ester bonds|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|aspartoacylase activity|central nervous system myelination|identical protein binding|metal ion binding|positive regulation of oligodendrocyte differentiation" "hsa00250,hsa00340" "Alanine, aspartate and glutamate metabolism|Histidine metabolism" ASPH 10701.80614 9205.582034 12198.03024 1.325068876 0.406067352 0.108737196 1 25.06172494 32.65281222 444 aspartate beta-hydroxylase "GO:0004597,GO:0005198,GO:0005509,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0006936,GO:0008307,GO:0009055,GO:0016021,GO:0018215,GO:0022900,GO:0032541,GO:0033017,GO:0034220,GO:0042264,GO:0045862,GO:0062101,GO:0097202,GO:1903779" peptide-aspartate beta-dioxygenase activity|structural molecule activity|calcium ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|muscle contraction|structural constituent of muscle|electron transfer activity|integral component of membrane|protein phosphopantetheinylation|electron transport chain|cortical endoplasmic reticulum|sarcoplasmic reticulum membrane|ion transmembrane transport|peptidyl-aspartic acid hydroxylation|positive regulation of proteolysis|peptidyl-aspartic acid 3-dioxygenase activity|activation of cysteine-type endopeptidase activity|regulation of cardiac conduction "hsa04020,hsa04260" Calcium signaling pathway|Cardiac muscle contraction ASPHD1 416.2623598 393.2764476 439.2482719 1.116894425 0.159492821 0.581664783 1 6.729221289 7.39006251 253982 aspartate beta-hydroxylase domain containing 1 "GO:0016021,GO:0018193,GO:0051213,GO:0055114" integral component of membrane|peptidyl-amino acid modification|dioxygenase activity|oxidation-reduction process ASPHD2 63.37151204 61.38441908 65.35860501 1.064742584 0.090504682 0.898351992 1 0.972098999 1.017715288 57168 aspartate beta-hydroxylase domain containing 2 "GO:0016020,GO:0016021,GO:0018193,GO:0046872,GO:0051213,GO:0055114" membrane|integral component of membrane|peptidyl-amino acid modification|metal ion binding|dioxygenase activity|oxidation-reduction process ASPM 4208.123292 5013.7545 3402.492084 0.678631569 -0.559299551 0.019258839 0.804292972 24.63176496 16.43617547 259266 assembly factor for spindle microtubules "GO:0005516,GO:0005634,GO:0005737,GO:0007051,GO:0036449,GO:0051301,GO:0051653,GO:0097431" calmodulin binding|nucleus|cytoplasm|spindle organization|microtubule minus-end|cell division|spindle localization|mitotic spindle pole ASPSCR1 319.5774818 315.2454064 323.9095572 1.027483829 0.039115688 0.909612185 1 6.446003044 6.512334209 79058 "ASPSCR1 tether for SLC2A4, UBX domain containing" "GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006886,GO:0009898,GO:0012505,GO:0012506,GO:0019898,GO:0031401,GO:0033116,GO:0042593,GO:0043231,GO:0046324,GO:0048471" protein binding|nucleoplasm|cytosol|plasma membrane|intracellular protein transport|cytoplasmic side of plasma membrane|endomembrane system|vesicle membrane|extrinsic component of membrane|positive regulation of protein modification process|endoplasmic reticulum-Golgi intermediate compartment membrane|glucose homeostasis|intracellular membrane-bounded organelle|regulation of glucose import|perinuclear region of cytoplasm hsa05202 Transcriptional misregulation in cancer ASRGL1 33.67002659 26.01034707 41.32970611 1.588971727 0.668093455 0.344998456 1 0.506984813 0.792104168 80150 asparaginase and isoaspartyl peptidase 1 "GO:0001917,GO:0003948,GO:0004067,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0006559,GO:0008798,GO:0033345" photoreceptor inner segment|N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity|asparaginase activity|nucleus|cytoplasm|cytosol|proteolysis|L-phenylalanine catabolic process|beta-aspartyl-peptidase activity|asparagine catabolic process via L-aspartate hsa00250 "Alanine, aspartate and glutamate metabolism" ASS1 268.2399265 304.8412676 231.6385854 0.759866232 -0.396182628 0.226376081 1 7.559859748 5.648356013 445 argininosuccinate synthase 1 "GO:0000050,GO:0000052,GO:0000053,GO:0001822,GO:0001889,GO:0003723,GO:0004055,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005741,GO:0005764,GO:0005783,GO:0005829,GO:0006526,GO:0006531,GO:0006953,GO:0007494,GO:0007568,GO:0007584,GO:0007623,GO:0010043,GO:0010046,GO:0015643,GO:0016597,GO:0032355,GO:0042493,GO:0042802,GO:0043204,GO:0045429,GO:0060416,GO:0060539,GO:0070062,GO:0070852,GO:0071222,GO:0071230,GO:0071242,GO:0071320,GO:0071346,GO:0071356,GO:0071377,GO:0071400,GO:0071418,GO:0071499,GO:0071549,GO:1903038" urea cycle|citrulline metabolic process|argininosuccinate metabolic process|kidney development|liver development|RNA binding|argininosuccinate synthase activity|protein binding|ATP binding|nucleus|cytoplasm|mitochondrial outer membrane|lysosome|endoplasmic reticulum|cytosol|arginine biosynthetic process|aspartate metabolic process|acute-phase response|midgut development|aging|response to nutrient|circadian rhythm|response to zinc ion|response to mycotoxin|toxic substance binding|amino acid binding|response to estradiol|response to drug|identical protein binding|perikaryon|positive regulation of nitric oxide biosynthetic process|response to growth hormone|diaphragm development|extracellular exosome|cell body fiber|cellular response to lipopolysaccharide|cellular response to amino acid stimulus|cellular response to ammonium ion|cellular response to cAMP|cellular response to interferon-gamma|cellular response to tumor necrosis factor|cellular response to glucagon stimulus|cellular response to oleic acid|cellular response to amine stimulus|cellular response to laminar fluid shear stress|cellular response to dexamethasone stimulus|negative regulation of leukocyte cell-cell adhesion "hsa00220,hsa00250,hsa05418" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|Fluid shear stress and atherosclerosis" ASTE1 124.2162169 132.1325631 116.2998707 0.880175696 -0.184136559 0.683675659 1 1.751968209 1.51623589 28990 asteroid homolog 1 "GO:0004518,GO:0005515,GO:0090305" nuclease activity|protein binding|nucleic acid phosphodiester bond hydrolysis ASTN2 89.30260118 111.3242854 67.28091692 0.604368729 -0.726499079 0.135572432 1 0.582068434 0.345897332 23245 astrotactin 2 "GO:0001764,GO:0005509,GO:0005768,GO:0005769,GO:0005770,GO:0005938,GO:0007158,GO:0015031,GO:0016021,GO:0030136,GO:0043204,GO:0043533,GO:0048105,GO:0060187,GO:2000009" "neuron migration|calcium ion binding|endosome|early endosome|late endosome|cell cortex|neuron cell-cell adhesion|protein transport|integral component of membrane|clathrin-coated vesicle|perikaryon|inositol 1,3,4,5 tetrakisphosphate binding|establishment of body hair planar orientation|cell pole|negative regulation of protein localization to cell surface" ASXL1 4475.62966 4554.931978 4396.327343 0.965179582 -0.051130699 0.831352159 1 23.88839898 22.67077405 171023 ASXL transcriptional regulator 1 "GO:0000902,GO:0003007,GO:0003677,GO:0003682,GO:0003713,GO:0005515,GO:0005654,GO:0006351,GO:0009887,GO:0010888,GO:0016579,GO:0030097,GO:0032526,GO:0035359,GO:0035517,GO:0035522,GO:0035564,GO:0042974,GO:0042975,GO:0045599,GO:0045944,GO:0046872,GO:0048386,GO:0048538,GO:0048539,GO:0048872,GO:0060430,GO:0072015" "cell morphogenesis|heart morphogenesis|DNA binding|chromatin binding|transcription coactivator activity|protein binding|nucleoplasm|transcription, DNA-templated|animal organ morphogenesis|negative regulation of lipid storage|protein deubiquitination|hemopoiesis|response to retinoic acid|negative regulation of peroxisome proliferator activated receptor signaling pathway|PR-DUB complex|monoubiquitinated histone H2A deubiquitination|regulation of kidney size|retinoic acid receptor binding|peroxisome proliferator activated receptor binding|negative regulation of fat cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of retinoic acid receptor signaling pathway|thymus development|bone marrow development|homeostasis of number of cells|lung saccule development|glomerular visceral epithelial cell development" other ASXL2 1335.725191 1494.034335 1177.416046 0.788078305 -0.34358911 0.152571126 1 6.028569981 4.671483906 55252 ASXL transcriptional regulator 2 "GO:0003677,GO:0003682,GO:0005654,GO:0006351,GO:0009887,GO:0010884,GO:0016579,GO:0035360,GO:0035517,GO:0042975,GO:0045600,GO:0045944,GO:0046872" "DNA binding|chromatin binding|nucleoplasm|transcription, DNA-templated|animal organ morphogenesis|positive regulation of lipid storage|protein deubiquitination|positive regulation of peroxisome proliferator activated receptor signaling pathway|PR-DUB complex|peroxisome proliferator activated receptor binding|positive regulation of fat cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding" ASXL3 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.007444357 0.00676217 80816 ASXL transcriptional regulator 3 "GO:0003677,GO:0003682,GO:0006351,GO:0009887,GO:0035517,GO:0042975,GO:0045944,GO:0046872,GO:0051055" "DNA binding|chromatin binding|transcription, DNA-templated|animal organ morphogenesis|PR-DUB complex|peroxisome proliferator activated receptor binding|positive regulation of transcription by RNA polymerase II|metal ion binding|negative regulation of lipid biosynthetic process" ATAD1 2658.160816 2475.144627 2841.177006 1.147883229 0.198975888 0.400331039 1 16.95032973 19.13141269 84896 ATPase family AAA domain containing 1 "GO:0002092,GO:0005524,GO:0005778,GO:0007612,GO:0007613,GO:0016020,GO:0016887,GO:0045211,GO:0051967,GO:0098978,GO:0099149" "positive regulation of receptor internalization|ATP binding|peroxisomal membrane|learning|memory|membrane|ATPase activity|postsynaptic membrane|negative regulation of synaptic transmission, glutamatergic|glutamatergic synapse|regulation of postsynaptic neurotransmitter receptor internalization" ATAD2 4730.344821 4731.802338 4728.887303 0.999383948 -0.000889049 0.998047784 1 45.52507556 44.73569858 29028 ATPase family AAA domain containing 2 "GO:0003682,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006325,GO:0006357,GO:0016887,GO:0031936,GO:0042393,GO:0045893,GO:0045944,GO:0070062" "chromatin binding|protein binding|ATP binding|nucleus|nucleoplasm|chromatin organization|regulation of transcription by RNA polymerase II|ATPase activity|negative regulation of chromatin silencing|histone binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|extracellular exosome" ATAD2B 239.9059475 254.9014012 224.9104937 0.882343104 -0.180588329 0.601845089 1 0.889823345 0.771991414 54454 ATPase family AAA domain containing 2B "GO:0003682,GO:0005524,GO:0005634,GO:0005654,GO:0016887,GO:0031936,GO:0042393,GO:0045944,GO:0070577" chromatin binding|ATP binding|nucleus|nucleoplasm|ATPase activity|negative regulation of chromatin silencing|histone binding|positive regulation of transcription by RNA polymerase II|lysine-acetylated histone binding ATAD3A 1092.649541 1054.979677 1130.319404 1.071413439 0.099515298 0.685801389 1 19.5290761 20.57358456 55210 ATPase family AAA domain containing 3A "GO:0001558,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0007005,GO:0008270,GO:0016021,GO:0016887,GO:0042645,GO:0043066,GO:0140374" regulation of cell growth|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|mitochondrion organization|zinc ion binding|integral component of membrane|ATPase activity|mitochondrial nucleoid|negative regulation of apoptotic process|antiviral innate immune response ATAD3B 465.4593367 448.4183834 482.5002899 1.076004704 0.105684385 0.709482757 1 4.495822838 4.756577067 83858 ATPase family AAA domain containing 3B "GO:0005524,GO:0005739,GO:0005743,GO:0005886,GO:0007005,GO:0008270,GO:0016887,GO:0030667,GO:0043312,GO:0101003" ATP binding|mitochondrion|mitochondrial inner membrane|plasma membrane|mitochondrion organization|zinc ion binding|ATPase activity|secretory granule membrane|neutrophil degranulation|ficolin-1-rich granule membrane ATAD5 679.5971269 745.9767539 613.2174999 0.822032988 -0.282731805 0.272354133 1 4.968972579 4.016308134 79915 ATPase family AAA domain containing 5 "GO:0003677,GO:0005515,GO:0005524,GO:0005634,GO:0006974,GO:0031391,GO:0045740,GO:0061860,GO:0090618,GO:1902751" DNA binding|protein binding|ATP binding|nucleus|cellular response to DNA damage stimulus|Elg1 RFC-like complex|positive regulation of DNA replication|DNA clamp unloader activity|DNA clamp unloading|positive regulation of cell cycle G2/M phase transition ATAT1 93.31580169 90.51600779 96.1155956 1.061862956 0.086597584 0.878664433 1 1.881103183 1.964048768 79969 alpha tubulin acetyltransferase 1 "GO:0004468,GO:0005794,GO:0005829,GO:0005874,GO:0005905,GO:0005925,GO:0007283,GO:0018215,GO:0019799,GO:0021542,GO:0030424,GO:0045598,GO:0048666,GO:0060271,GO:0070507,GO:0071929,GO:0072686,GO:0097427,GO:1900227" "lysine N-acetyltransferase activity, acting on acetyl phosphate as donor|Golgi apparatus|cytosol|microtubule|clathrin-coated pit|focal adhesion|spermatogenesis|protein phosphopantetheinylation|tubulin N-acetyltransferase activity|dentate gyrus development|axon|regulation of fat cell differentiation|neuron development|cilium assembly|regulation of microtubule cytoskeleton organization|alpha-tubulin acetylation|mitotic spindle|microtubule bundle|positive regulation of NLRP3 inflammasome complex assembly" ATE1 520.3685291 539.9748051 500.7622531 0.927380775 -0.108766276 0.692855311 1 4.627824461 4.219938719 11101 arginyltransferase 1 "GO:0004057,GO:0005515,GO:0005634,GO:0005737,GO:0010498,GO:0016598" arginyltransferase activity|protein binding|nucleus|cytoplasm|proteasomal protein catabolic process|protein arginylation ATF1 487.654628 526.4494246 448.8598314 0.852617194 -0.230029945 0.404514807 1 5.341376087 4.477941577 466 activating transcription factor 1 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0010976,GO:0014070,GO:0032025,GO:0034622,GO:0042802,GO:0044877,GO:0045740,GO:0045944,GO:0046982,GO:1990589,GO:1990590" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|positive regulation of neuron projection development|response to organic cyclic compound|response to cobalt ion|cellular protein-containing complex assembly|identical protein binding|protein-containing complex binding|positive regulation of DNA replication|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|ATF4-CREB1 transcription factor complex|ATF1-ATF4 transcription factor complex" "hsa04925,hsa05202" Aldosterone synthesis and secretion|Transcriptional misregulation in cancer TF_bZIP ATF2 1526.241661 1575.186618 1477.296704 0.937855037 -0.09256315 0.699663204 1 18.09401953 16.68560463 1386 activating transcription factor 2 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0000987,GO:0001102,GO:0001228,GO:0003151,GO:0003682,GO:0003700,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005741,GO:0006355,GO:0006357,GO:0006970,GO:0006974,GO:0008140,GO:0009414,GO:0010485,GO:0010628,GO:0016525,GO:0019901,GO:0031573,GO:0032915,GO:0035497,GO:0035861,GO:0043525,GO:0043967,GO:0043969,GO:0044013,GO:0044877,GO:0045444,GO:0045944,GO:0046872,GO:0050680,GO:0051090,GO:0051091,GO:0060612,GO:0097186,GO:0110024,GO:1902110,GO:1902562,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|outflow tract morphogenesis|chromatin binding|DNA-binding transcription factor activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrial outer membrane|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|response to osmotic stress|cellular response to DNA damage stimulus|cAMP response element binding protein binding|response to water deprivation|H4 histone acetyltransferase activity|positive regulation of gene expression|negative regulation of angiogenesis|protein kinase binding|intra-S DNA damage checkpoint|positive regulation of transforming growth factor beta2 production|cAMP response element binding|site of double-strand break|positive regulation of neuron apoptotic process|histone H4 acetylation|histone H2B acetylation|H2B histone acetyltransferase activity|protein-containing complex binding|fat cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|negative regulation of epithelial cell proliferation|regulation of DNA-binding transcription factor activity|positive regulation of DNA-binding transcription factor activity|adipose tissue development|amelogenesis|positive regulation of cardiac muscle myoblast proliferation|positive regulation of mitochondrial membrane permeability involved in apoptotic process|H4 histone acetyltransferase complex|sequence-specific double-stranded DNA binding" "hsa04010,hsa04022,hsa04151,hsa04211,hsa04261,hsa04668,hsa04714,hsa04728,hsa04911,hsa04915,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa05020,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05166,hsa05203" "MAPK signaling pathway|cGMP-PKG signaling pathway|PI3K-Akt signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Thermogenesis|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Prion disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis" TF_bZIP ATF3 122.2341543 181.0320156 63.4362931 0.350414775 -1.512864486 0.00064974 0.145659001 3.371020917 1.161488826 467 activating transcription factor 3 "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006094,GO:0006357,GO:0008284,GO:0034198,GO:0035914,GO:0036499,GO:0042802,GO:0042803,GO:0045944,GO:0046982,GO:0061394,GO:0070373,GO:1903984,GO:1990440,GO:1990622,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|gluconeogenesis|regulation of transcription by RNA polymerase II|positive regulation of cell population proliferation|cellular response to amino acid starvation|skeletal muscle cell differentiation|PERK-mediated unfolded protein response|identical protein binding|protein homodimerization activity|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|negative regulation of ERK1 and ERK2 cascade|positive regulation of TRAIL-activated apoptotic signaling pathway|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|CHOP-ATF3 complex|sequence-specific double-stranded DNA binding" TF_bZIP ATF4 9487.224113 10500.89732 8473.550908 0.806935889 -0.30947404 0.216157995 1 72.65831583 57.64949892 468 activating transcription factor 4 "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001085,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0006094,GO:0006355,GO:0006357,GO:0006366,GO:0006874,GO:0007214,GO:0008022,GO:0008140,GO:0009636,GO:0010575,GO:0010628,GO:0016607,GO:0019901,GO:0030182,GO:0030282,GO:0030968,GO:0031667,GO:0032057,GO:0032590,GO:0032922,GO:0032991,GO:0034198,GO:0034399,GO:0034599,GO:0034644,GO:0034976,GO:0035162,GO:0036003,GO:0036091,GO:0036499,GO:0042149,GO:0042789,GO:0043005,GO:0043065,GO:0043267,GO:0043522,GO:0043525,GO:0043565,GO:0045667,GO:0045893,GO:0045943,GO:0045944,GO:0046982,GO:0048167,GO:0061395,GO:0070059,GO:0070169,GO:0070309,GO:0070982,GO:0090650,GO:0120163,GO:0140467,GO:0140468,GO:1903204,GO:1903351,GO:1905461,GO:1990037,GO:1990440,GO:1990589,GO:1990590,GO:1990617,GO:1990737,GO:1990837,GO:2000120" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|gluconeogenesis|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|cellular calcium ion homeostasis|gamma-aminobutyric acid signaling pathway|protein C-terminus binding|cAMP response element binding protein binding|response to toxic substance|positive regulation of vascular endothelial growth factor production|positive regulation of gene expression|nuclear speck|protein kinase binding|neuron differentiation|bone mineralization|endoplasmic reticulum unfolded protein response|response to nutrient levels|negative regulation of translational initiation in response to stress|dendrite membrane|circadian regulation of gene expression|protein-containing complex|cellular response to amino acid starvation|nuclear periphery|cellular response to oxidative stress|cellular response to UV|response to endoplasmic reticulum stress|embryonic hemopoiesis|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress|PERK-mediated unfolded protein response|cellular response to glucose starvation|mRNA transcription by RNA polymerase II|neuron projection|positive regulation of apoptotic process|negative regulation of potassium ion transport|leucine zipper domain binding|positive regulation of neuron apoptotic process|sequence-specific DNA binding|regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase I|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|regulation of synaptic plasticity|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|positive regulation of biomineral tissue development|lens fiber cell morphogenesis|L-asparagine metabolic process|cellular response to oxygen-glucose deprivation|negative regulation of cold-induced thermogenesis|integrated stress response signaling|HRI-mediated signaling|negative regulation of oxidative stress-induced neuron death|cellular response to dopamine|positive regulation of vascular associated smooth muscle cell apoptotic process|Lewy body core|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|ATF4-CREB1 transcription factor complex|ATF1-ATF4 transcription factor complex|CHOP-ATF4 complex|response to manganese-induced endoplasmic reticulum stress|sequence-specific double-stranded DNA binding|positive regulation of sodium-dependent phosphate transport" "hsa04010,hsa04022,hsa04137,hsa04141,hsa04151,hsa04210,hsa04211,hsa04261,hsa04668,hsa04720,hsa04722,hsa04725,hsa04728,hsa04911,hsa04912,hsa04915,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04932,hsa04934,hsa04935,hsa05010,hsa05012,hsa05014,hsa05020,hsa05022,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05166,hsa05203,hsa05215" "MAPK signaling pathway|cGMP-PKG signaling pathway|Mitophagy - animal|Protein processing in endoplasmic reticulum|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Non-alcoholic fatty liver disease|Cushing syndrome|Growth hormone synthesis, secretion and action|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis|Prostate cancer" ATF5 134.3479834 133.172977 135.5229898 1.017646319 0.025236242 0.972064964 1 2.571344797 2.572932309 22809 activating transcription factor 5 "GO:0000785,GO:0000976,GO:0000977,GO:0000981,GO:0001228,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005813,GO:0005829,GO:0006355,GO:0006357,GO:0007623,GO:0008285,GO:0009791,GO:0015631,GO:0019900,GO:0021891,GO:0021930,GO:0035264,GO:0043066,GO:0043565,GO:0045444,GO:0045892,GO:0045893,GO:0045944,GO:0046605,GO:1902750" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|centrosome|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|circadian rhythm|negative regulation of cell population proliferation|post-embryonic development|tubulin binding|kinase binding|olfactory bulb interneuron development|cerebellar granule cell precursor proliferation|multicellular organism growth|negative regulation of apoptotic process|sequence-specific DNA binding|fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of centrosome cycle|negative regulation of cell cycle G2/M phase transition" TF_bZIP ATF6 2595.144122 2725.884373 2464.403871 0.904074984 -0.14548566 0.538843159 1 18.43795171 16.39035289 22926 activating transcription factor 6 "GO:0000139,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001654,GO:0003700,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006357,GO:0006457,GO:0007165,GO:0007601,GO:0010508,GO:0016020,GO:0030176,GO:0030968,GO:0035497,GO:0036500,GO:0042802,GO:0043065,GO:0043565,GO:0045944,GO:0046982,GO:1903893,GO:1990440,GO:1990837" "Golgi membrane|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|eye development|DNA-binding transcription factor activity|protein binding|nucleus|nuclear envelope|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|regulation of transcription by RNA polymerase II|protein folding|signal transduction|visual perception|positive regulation of autophagy|membrane|integral component of endoplasmic reticulum membrane|endoplasmic reticulum unfolded protein response|cAMP response element binding|ATF6-mediated unfolded protein response|identical protein binding|positive regulation of apoptotic process|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|positive regulation of ATF6-mediated unfolded protein response|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|sequence-specific double-stranded DNA binding" "hsa04141,hsa05010,hsa05012,hsa05014,hsa05022" Protein processing in endoplasmic reticulum|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases ATF6B 1309.541237 1475.306886 1143.775588 0.775279773 -0.367211069 0.126797435 1 29.98264165 22.8559631 1388 activating transcription factor 6 beta "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005789,GO:0005794,GO:0006357,GO:0007165,GO:0030176,GO:0030968,GO:0032993,GO:0035497,GO:0036500,GO:0045944,GO:0090575,GO:1903892,GO:1990440,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|endoplasmic reticulum membrane|Golgi apparatus|regulation of transcription by RNA polymerase II|signal transduction|integral component of endoplasmic reticulum membrane|endoplasmic reticulum unfolded protein response|protein-DNA complex|cAMP response element binding|ATF6-mediated unfolded protein response|positive regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulator complex|negative regulation of ATF6-mediated unfolded protein response|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|sequence-specific double-stranded DNA binding" "hsa04022,hsa04141,hsa04151,hsa04211,hsa04261,hsa04668,hsa04728,hsa04911,hsa04915,hsa04918,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa05020,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05166,hsa05203" "cGMP-PKG signaling pathway|Protein processing in endoplasmic reticulum|PI3K-Akt signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Thyroid hormone synthesis|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Prion disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis" ATF7 926.8752903 992.554844 861.1957366 0.867655568 -0.204805644 0.40909068 1 6.268737016 5.348088525 11016 activating transcription factor 7 "GO:0000781,GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006357,GO:0008134,GO:0016032,GO:0019899,GO:0034399,GO:0035497,GO:0046872,GO:0051019,GO:1990837" "chromosome, telomeric region|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription factor binding|viral process|enzyme binding|nuclear periphery|cAMP response element binding|metal ion binding|mitogen-activated protein kinase binding|sequence-specific double-stranded DNA binding" ATF7IP 2238.245718 2301.395508 2175.095928 0.945120437 -0.081429911 0.731767371 1 11.50334818 10.69012043 55729 activating transcription factor 7 interacting protein "GO:0000122,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006306,GO:0016032,GO:0016604,GO:0016887,GO:0031647,GO:0045892,GO:0045893,GO:0045898,GO:0050821,GO:0090309" "negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|DNA methylation|viral process|nuclear body|ATPase activity|regulation of protein stability|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|regulation of RNA polymerase II transcription preinitiation complex assembly|protein stabilization|positive regulation of DNA methylation-dependent heterochromatin assembly" other ATG10 314.8610208 292.356301 337.3657406 1.15395406 0.20658579 0.509466114 1 1.972256157 2.237809013 83734 autophagy related 10 "GO:0005515,GO:0005829,GO:0006497,GO:0006914,GO:0006983,GO:0015031,GO:0016236,GO:0018215,GO:0019777,GO:0031401,GO:0032446" protein binding|cytosol|protein lipidation|autophagy|ER overload response|protein transport|macroautophagy|protein phosphopantetheinylation|Atg12 transferase activity|positive regulation of protein modification process|protein modification by small protein conjugation "hsa04136,hsa04140" Autophagy - other|Autophagy - animal ATG101 855.5924625 786.5528953 924.6320297 1.175549712 0.23333555 0.35085331 1 32.743278 37.8472504 60673 autophagy related 101 "GO:0000045,GO:0000407,GO:0005515,GO:0005789,GO:0005829,GO:0016236,GO:0016241,GO:0042802,GO:0044877" autophagosome assembly|phagophore assembly site|protein binding|endoplasmic reticulum membrane|cytosol|macroautophagy|regulation of macroautophagy|identical protein binding|protein-containing complex binding "hsa04136,hsa04140,hsa04211,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022" Autophagy - other|Autophagy - animal|Longevity regulating pathway|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ATG12 1615.421574 1494.034335 1736.808812 1.162495915 0.217225647 0.361572697 1 19.73610559 22.55921972 9140 autophagy related 12 "GO:0000045,GO:0000422,GO:0005515,GO:0005776,GO:0005829,GO:0006501,GO:0016032,GO:0016236,GO:0030670,GO:0034045,GO:0034274,GO:0044804" autophagosome assembly|autophagy of mitochondrion|protein binding|autophagosome|cytosol|C-terminal protein lipidation|viral process|macroautophagy|phagocytic vesicle membrane|phagophore assembly site membrane|Atg12-Atg5-Atg16 complex|autophagy of nucleus "hsa04068,hsa04136,hsa04140,hsa04621,hsa04622,hsa05131" FoxO signaling pathway|Autophagy - other|Autophagy - animal|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Shigellosis ATG13 2013.302469 1985.109688 2041.495251 1.028404255 0.040407485 0.866353987 1 18.74078464 18.9505934 9776 autophagy related 13 "GO:0000045,GO:0000407,GO:0000423,GO:0005515,GO:0005739,GO:0005789,GO:0005829,GO:0016236,GO:0016241,GO:0019898,GO:0019901,GO:0034497,GO:0034727,GO:0098780,GO:1903955,GO:1990316" autophagosome assembly|phagophore assembly site|mitophagy|protein binding|mitochondrion|endoplasmic reticulum membrane|cytosol|macroautophagy|regulation of macroautophagy|extrinsic component of membrane|protein kinase binding|protein localization to phagophore assembly site|piecemeal microautophagy of the nucleus|response to mitochondrial depolarisation|positive regulation of protein targeting to mitochondrion|Atg1/ULK1 kinase complex "hsa04136,hsa04140,hsa04211,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022" Autophagy - other|Autophagy - animal|Longevity regulating pathway|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ATG14 565.4485098 575.3488771 555.5481426 0.965584821 -0.050525098 0.85566332 1 6.421018847 6.096289089 22863 autophagy related 14 "GO:0000045,GO:0000421,GO:0000423,GO:0001932,GO:0001933,GO:0001934,GO:0005515,GO:0005776,GO:0005789,GO:0005829,GO:0005930,GO:0008333,GO:0009267,GO:0010608,GO:0016236,GO:0016240,GO:0034045,GO:0035032,GO:0042149,GO:0043552,GO:0044233,GO:0045335,GO:0051020,GO:0061635,GO:0090207,GO:0097629,GO:0097632,GO:0098780" "autophagosome assembly|autophagosome membrane|mitophagy|regulation of protein phosphorylation|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|protein binding|autophagosome|endoplasmic reticulum membrane|cytosol|axoneme|endosome to lysosome transport|cellular response to starvation|posttranscriptional regulation of gene expression|macroautophagy|autophagosome membrane docking|phagophore assembly site membrane|phosphatidylinositol 3-kinase complex, class III|cellular response to glucose starvation|positive regulation of phosphatidylinositol 3-kinase activity|mitochondria-associated endoplasmic reticulum membrane|phagocytic vesicle|GTPase binding|regulation of protein complex stability|regulation of triglyceride metabolic process|extrinsic component of omegasome membrane|extrinsic component of phagophore assembly site membrane|response to mitochondrial depolarisation" "hsa04140,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022,hsa05131,hsa05167" Autophagy - animal|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis|Kaposi sarcoma-associated herpesvirus infection ATG16L1 626.0359336 588.8742576 663.1976096 1.126212602 0.171479199 0.513594834 1 9.311744244 10.3115179 55054 autophagy related 16 like 1 "GO:0000045,GO:0000421,GO:0005515,GO:0005776,GO:0005829,GO:0005930,GO:0015031,GO:0016236,GO:0018215,GO:0019787,GO:0034045,GO:0039689,GO:0042802,GO:0051020" autophagosome assembly|autophagosome membrane|protein binding|autophagosome|cytosol|axoneme|protein transport|macroautophagy|protein phosphopantetheinylation|ubiquitin-like protein transferase activity|phagophore assembly site membrane|negative stranded viral RNA replication|identical protein binding|GTPase binding "hsa04136,hsa04140,hsa04621,hsa05131" Autophagy - other|Autophagy - animal|NOD-like receptor signaling pathway|Shigellosis ATG16L2 928.8774745 893.7155252 964.0394239 1.078687118 0.10927646 0.66163039 1 6.695108787 7.101078422 89849 autophagy related 16 like 2 "GO:0000045,GO:0000421,GO:0005654,GO:0005776,GO:0005829,GO:0006914,GO:0015031,GO:0039689" autophagosome assembly|autophagosome membrane|nucleoplasm|autophagosome|cytosol|autophagy|protein transport|negative stranded viral RNA replication hsa04140 Autophagy - animal ATG2A 1030.63989 1092.434577 968.8452036 0.886867941 -0.173208799 0.481135618 1 9.119540991 7.952489682 23130 autophagy related 2A "GO:0000045,GO:0000407,GO:0000422,GO:0005515,GO:0005789,GO:0005811,GO:0019898,GO:0032266,GO:0034045,GO:0034727,GO:0044805,GO:0061709" autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|protein binding|endoplasmic reticulum membrane|lipid droplet|extrinsic component of membrane|phosphatidylinositol-3-phosphate binding|phagophore assembly site membrane|piecemeal microautophagy of the nucleus|late nucleophagy|reticulophagy "hsa04136,hsa04140,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022" Autophagy - other|Autophagy - animal|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ATG2B 1123.405302 1256.81997 989.9906347 0.787694863 -0.344291227 0.157136465 1 5.096047096 3.946959089 55102 autophagy related 2B "GO:0000045,GO:0000407,GO:0000422,GO:0005654,GO:0005789,GO:0005811,GO:0019898,GO:0032266,GO:0034045,GO:0034727,GO:0044805,GO:0061709,GO:0120009,GO:0120013" autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|nucleoplasm|endoplasmic reticulum membrane|lipid droplet|extrinsic component of membrane|phosphatidylinositol-3-phosphate binding|phagophore assembly site membrane|piecemeal microautophagy of the nucleus|late nucleophagy|reticulophagy|intermembrane lipid transfer|lipid transfer activity "hsa04136,hsa04140,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022" Autophagy - other|Autophagy - animal|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ATG3 1112.551383 1060.181746 1164.921019 1.098793695 0.135920537 0.578640743 1 18.51438196 20.00306548 64422 autophagy related 3 "GO:0000045,GO:0000153,GO:0000422,GO:0005515,GO:0005829,GO:0006464,GO:0006612,GO:0016236,GO:0016567,GO:0018215,GO:0019776,GO:0019777,GO:0019787,GO:0019899,GO:0043653,GO:0044804,GO:0050765,GO:1902017" autophagosome assembly|cytoplasmic ubiquitin ligase complex|autophagy of mitochondrion|protein binding|cytosol|cellular protein modification process|protein targeting to membrane|macroautophagy|protein ubiquitination|protein phosphopantetheinylation|Atg8 ligase activity|Atg12 transferase activity|ubiquitin-like protein transferase activity|enzyme binding|mitochondrial fragmentation involved in apoptotic process|autophagy of nucleus|negative regulation of phagocytosis|regulation of cilium assembly "hsa04136,hsa04140,hsa05167" Autophagy - other|Autophagy - animal|Kaposi sarcoma-associated herpesvirus infection ATG4A 396.0485166 367.2661006 424.8309325 1.156738757 0.210063076 0.472009069 1 7.686398738 8.742373876 115201 autophagy related 4A cysteine peptidase "GO:0004197,GO:0005515,GO:0005737,GO:0006508,GO:0006914,GO:0008234,GO:0015031" cysteine-type endopeptidase activity|protein binding|cytoplasm|proteolysis|autophagy|cysteine-type peptidase activity|protein transport "hsa04136,hsa04140" Autophagy - other|Autophagy - animal ATG4B 933.266843 933.2512527 933.2824333 1.000033411 4.82E-05 1 1 25.26935774 24.8473394 23192 autophagy related 4B cysteine peptidase "GO:0004175,GO:0004197,GO:0005515,GO:0005829,GO:0006508,GO:0006914,GO:0008234,GO:0015031,GO:0016236,GO:0045732,GO:0051697" endopeptidase activity|cysteine-type endopeptidase activity|protein binding|cytosol|proteolysis|autophagy|cysteine-type peptidase activity|protein transport|macroautophagy|positive regulation of protein catabolic process|protein delipidation "hsa04136,hsa04140" Autophagy - other|Autophagy - animal ATG4C 427.2363953 391.1956199 463.2771708 1.184259606 0.243985375 0.392618906 1 4.239925111 4.937149528 84938 autophagy related 4C cysteine peptidase "GO:0004197,GO:0005515,GO:0005575,GO:0005737,GO:0006508,GO:0006914,GO:0008234,GO:0015031" cysteine-type endopeptidase activity|protein binding|cellular_component|cytoplasm|proteolysis|autophagy|cysteine-type peptidase activity|protein transport "hsa04136,hsa04140" Autophagy - other|Autophagy - animal ATG4D 331.4780748 299.6391982 363.3169514 1.212514763 0.278002313 0.364547866 1 7.823480085 9.327348313 84971 autophagy related 4D cysteine peptidase "GO:0005654,GO:0005739,GO:0005759,GO:0006508,GO:0006914,GO:0006915,GO:0008234,GO:0015031" nucleoplasm|mitochondrion|mitochondrial matrix|proteolysis|autophagy|apoptotic process|cysteine-type peptidase activity|protein transport "hsa04136,hsa04140" Autophagy - other|Autophagy - animal ATG5 774.7761042 784.4720675 765.080141 0.975280284 -0.036111203 0.891422074 1 12.553473 12.0382821 9474 autophagy related 5 "GO:0000045,GO:0000422,GO:0001974,GO:0002718,GO:0005515,GO:0005737,GO:0005776,GO:0005829,GO:0005930,GO:0006501,GO:0006914,GO:0006915,GO:0006995,GO:0009620,GO:0016020,GO:0016236,GO:0019883,GO:0030670,GO:0031397,GO:0034045,GO:0034274,GO:0035973,GO:0039689,GO:0042311,GO:0042493,GO:0043066,GO:0043687,GO:0044233,GO:0044804,GO:0045060,GO:0048840,GO:0050765,GO:0051279,GO:0055015,GO:0060047,GO:0060548,GO:0061739,GO:0070257,GO:0071500,GO:0075044,GO:1902017,GO:2000378,GO:2000619" autophagosome assembly|autophagy of mitochondrion|blood vessel remodeling|regulation of cytokine production involved in immune response|protein binding|cytoplasm|autophagosome|cytosol|axoneme|C-terminal protein lipidation|autophagy|apoptotic process|cellular response to nitrogen starvation|response to fungus|membrane|macroautophagy|antigen processing and presentation of endogenous antigen|phagocytic vesicle membrane|negative regulation of protein ubiquitination|phagophore assembly site membrane|Atg12-Atg5-Atg16 complex|aggrephagy|negative stranded viral RNA replication|vasodilation|response to drug|negative regulation of apoptotic process|post-translational protein modification|mitochondria-associated endoplasmic reticulum membrane|autophagy of nucleus|negative thymic T cell selection|otolith development|negative regulation of phagocytosis|regulation of release of sequestered calcium ion into cytosol|ventricular cardiac muscle cell development|heart contraction|negative regulation of cell death|protein lipidation involved in autophagosome assembly|positive regulation of mucus secretion|cellular response to nitrosative stress|positive regulation by symbiont of host autophagy|regulation of cilium assembly|negative regulation of reactive oxygen species metabolic process|negative regulation of histone H4-K16 acetylation "hsa04136,hsa04137,hsa04140,hsa04211,hsa04213,hsa04216,hsa04621,hsa04622,hsa05131" Autophagy - other|Mitophagy - animal|Autophagy - animal|Longevity regulating pathway|Longevity regulating pathway - multiple species|Ferroptosis|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Shigellosis ATG7 1126.963691 1072.666713 1181.26067 1.10123737 0.139125473 0.569205386 1 8.630521784 9.345212307 10533 autophagy related 7 "GO:0000045,GO:0000407,GO:0000422,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0005930,GO:0006497,GO:0006501,GO:0006914,GO:0006995,GO:0007568,GO:0008134,GO:0009267,GO:0009749,GO:0015031,GO:0016236,GO:0018215,GO:0019778,GO:0019779,GO:0030424,GO:0031401,GO:0032446,GO:0034727,GO:0034774,GO:0039521,GO:0042752,GO:0042803,GO:0043065,GO:0043312,GO:0044805,GO:0045732,GO:0048511,GO:0051607,GO:0061684,GO:0071315,GO:0071455,GO:0075044,GO:0090298,GO:1902617,GO:1903204,GO:1904813" autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|protein binding|extracellular region|cytoplasm|cytosol|axoneme|protein lipidation|C-terminal protein lipidation|autophagy|cellular response to nitrogen starvation|aging|transcription factor binding|cellular response to starvation|response to glucose|protein transport|macroautophagy|protein phosphopantetheinylation|Atg12 activating enzyme activity|Atg8 activating enzyme activity|axon|positive regulation of protein modification process|protein modification by small protein conjugation|piecemeal microautophagy of the nucleus|secretory granule lumen|suppression by virus of host autophagy|regulation of circadian rhythm|protein homodimerization activity|positive regulation of apoptotic process|neutrophil degranulation|late nucleophagy|positive regulation of protein catabolic process|rhythmic process|defense response to virus|chaperone-mediated autophagy|cellular response to morphine|cellular response to hyperoxia|positive regulation by symbiont of host autophagy|negative regulation of mitochondrial DNA replication|response to fluoride|negative regulation of oxidative stress-induced neuron death|ficolin-1-rich granule lumen "hsa04136,hsa04140,hsa04216" Autophagy - other|Autophagy - animal|Ferroptosis ATG9A 1220.318508 1265.143281 1175.493734 0.929138819 -0.106033935 0.663058494 1 17.90938241 16.3618495 79065 autophagy related 9A "GO:0000045,GO:0000407,GO:0000421,GO:0000422,GO:0005515,GO:0005768,GO:0005770,GO:0005776,GO:0005789,GO:0005802,GO:0015031,GO:0016020,GO:0016021,GO:0031902,GO:0034497,GO:0043231,GO:0044805,GO:0055037" autophagosome assembly|phagophore assembly site|autophagosome membrane|autophagy of mitochondrion|protein binding|endosome|late endosome|autophagosome|endoplasmic reticulum membrane|trans-Golgi network|protein transport|membrane|integral component of membrane|late endosome membrane|protein localization to phagophore assembly site|intracellular membrane-bounded organelle|late nucleophagy|recycling endosome "hsa04136,hsa04137,hsa04140" Autophagy - other|Mitophagy - animal|Autophagy - animal ATG9B 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.012602128 0.034341879 285973 autophagy related 9B "GO:0000045,GO:0000407,GO:0000421,GO:0000422,GO:0005776,GO:0016021,GO:0031410,GO:0034497,GO:0044805" autophagosome assembly|phagophore assembly site|autophagosome membrane|autophagy of mitochondrion|autophagosome|integral component of membrane|cytoplasmic vesicle|protein localization to phagophore assembly site|late nucleophagy "hsa04136,hsa04137,hsa04140" Autophagy - other|Mitophagy - animal|Autophagy - animal ATIC 3305.905819 3255.455039 3356.356598 1.03099461 0.04403679 0.85377525 1 63.3154709 64.18557182 471 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase "GO:0003360,GO:0003937,GO:0004643,GO:0005829,GO:0005886,GO:0006139,GO:0006189,GO:0009116,GO:0009168,GO:0010035,GO:0016020,GO:0021549,GO:0021987,GO:0031100,GO:0042803,GO:0045296,GO:0046452,GO:0046654,GO:0070062,GO:0098761" brainstem development|IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|cytosol|plasma membrane|nucleobase-containing compound metabolic process|'de novo' IMP biosynthetic process|nucleoside metabolic process|purine ribonucleoside monophosphate biosynthetic process|response to inorganic substance|membrane|cerebellum development|cerebral cortex development|animal organ regeneration|protein homodimerization activity|cadherin binding|dihydrofolate metabolic process|tetrahydrofolate biosynthetic process|extracellular exosome|cellular response to interleukin-7 "hsa00230,hsa00670,hsa01523" Purine metabolism|One carbon pool by folate|Antifolate resistance ATL1 303.8574171 268.4267817 339.2880525 1.263987335 0.337982008 0.282142309 1 5.101653844 6.340520172 51062 atlastin GTPase 1 "GO:0000137,GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005783,GO:0005789,GO:0005794,GO:0007029,GO:0007409,GO:0016021,GO:0030424,GO:0042802,GO:0051260,GO:0071782,GO:0098826,GO:1990809" Golgi cis cisterna|Golgi membrane|GTPase activity|protein binding|GTP binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|endoplasmic reticulum organization|axonogenesis|integral component of membrane|axon|identical protein binding|protein homooligomerization|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network membrane|endoplasmic reticulum tubular network membrane organization ATL2 984.4352072 1065.383816 903.4865986 0.848038599 -0.237798163 0.334557435 1 8.652804163 7.215121902 64225 atlastin GTPase 2 "GO:0003924,GO:0005515,GO:0005525,GO:0005783,GO:0005789,GO:0006888,GO:0007029,GO:0007030,GO:0016020,GO:0016021,GO:0042802,GO:0051260,GO:0098826,GO:1990809" GTPase activity|protein binding|GTP binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|endoplasmic reticulum organization|Golgi organization|membrane|integral component of membrane|identical protein binding|protein homooligomerization|endoplasmic reticulum tubular network membrane|endoplasmic reticulum tubular network membrane organization ATL3 2006.030247 1844.653814 2167.406681 1.174966633 0.232619787 0.325767974 1 13.33953709 15.411236 25923 atlastin GTPase 3 "GO:0003924,GO:0005515,GO:0005525,GO:0005783,GO:0005789,GO:0006888,GO:0007029,GO:0007030,GO:0016020,GO:0016021,GO:0042802,GO:0051260,GO:0071782,GO:0098826,GO:1903373" GTPase activity|protein binding|GTP binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|endoplasmic reticulum organization|Golgi organization|membrane|integral component of membrane|identical protein binding|protein homooligomerization|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network membrane|positive regulation of endoplasmic reticulum tubular network organization ATM 2254.109208 2389.830688 2118.387727 0.886417493 -0.173941743 0.462246408 1 10.9684272 9.559911101 472 ATM serine/threonine kinase "GO:0000077,GO:0000723,GO:0000724,GO:0000729,GO:0000781,GO:0001541,GO:0001666,GO:0001756,GO:0002331,GO:0003677,GO:0004674,GO:0004677,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005819,GO:0006260,GO:0006303,GO:0006468,GO:0006974,GO:0006975,GO:0006977,GO:0007050,GO:0007094,GO:0007131,GO:0007140,GO:0007143,GO:0007165,GO:0007420,GO:0007507,GO:0008340,GO:0008630,GO:0009791,GO:0010212,GO:0010506,GO:0010628,GO:0016303,GO:0016572,GO:0018105,GO:0030335,GO:0030889,GO:0031410,GO:0032210,GO:0032212,GO:0033129,GO:0033151,GO:0035264,GO:0036092,GO:0036289,GO:0042159,GO:0042802,GO:0042981,GO:0043065,GO:0043231,GO:0043517,GO:0043525,GO:0044877,GO:0045141,GO:0045785,GO:0045944,GO:0046777,GO:0047485,GO:0048538,GO:0048599,GO:0051402,GO:0051972,GO:0071044,GO:0071300,GO:0071480,GO:0071481,GO:0071500,GO:0072434,GO:0090399,GO:0097694,GO:0097695,GO:0106310,GO:0106311,GO:1900034,GO:1901796,GO:1903626,GO:1903978,GO:1904262,GO:1904354,GO:1904358,GO:1904884,GO:1905843,GO:1990391" "DNA damage checkpoint|telomere maintenance|double-strand break repair via homologous recombination|DNA double-strand break processing|chromosome, telomeric region|ovarian follicle development|response to hypoxia|somitogenesis|pre-B cell allelic exclusion|DNA binding|protein serine/threonine kinase activity|DNA-dependent protein kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|spindle|DNA replication|double-strand break repair via nonhomologous end joining|protein phosphorylation|cellular response to DNA damage stimulus|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|cell cycle arrest|mitotic spindle assembly checkpoint|reciprocal meiotic recombination|male meiotic nuclear division|female meiotic nuclear division|signal transduction|brain development|heart development|determination of adult lifespan|intrinsic apoptotic signaling pathway in response to DNA damage|post-embryonic development|response to ionizing radiation|regulation of autophagy|positive regulation of gene expression|1-phosphatidylinositol-3-kinase activity|histone phosphorylation|peptidyl-serine phosphorylation|positive regulation of cell migration|negative regulation of B cell proliferation|cytoplasmic vesicle|regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance via telomerase|positive regulation of histone phosphorylation|V(D)J recombination|multicellular organism growth|phosphatidylinositol-3-phosphate biosynthetic process|peptidyl-serine autophosphorylation|lipoprotein catabolic process|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of neuron apoptotic process|protein-containing complex binding|meiotic telomere clustering|positive regulation of cell adhesion|positive regulation of transcription by RNA polymerase II|protein autophosphorylation|protein N-terminus binding|thymus development|oocyte development|neuron apoptotic process|regulation of telomerase activity|histone mRNA catabolic process|cellular response to retinoic acid|cellular response to gamma radiation|cellular response to X-ray|cellular response to nitrosative stress|signal transduction involved in mitotic G2 DNA damage checkpoint|replicative senescence|establishment of RNA localization to telomere|establishment of protein-containing complex localization to telomere|protein serine kinase activity|protein threonine kinase activity|regulation of cellular response to heat|regulation of signal transduction by p53 class mediator|positive regulation of DNA catabolic process|regulation of microglial cell activation|negative regulation of TORC1 signaling|negative regulation of telomere capping|positive regulation of telomere maintenance via telomere lengthening|positive regulation of telomerase catalytic core complex assembly|regulation of cellular response to gamma radiation|DNA repair complex" "hsa01524,hsa03440,hsa04064,hsa04068,hsa04110,hsa04115,hsa04210,hsa04218,hsa05131,hsa05165,hsa05166,hsa05170,hsa05202,hsa05206" Platinum drug resistance|Homologous recombination|NF-kappa B signaling pathway|FoxO signaling pathway|Cell cycle|p53 signaling pathway|Apoptosis|Cellular senescence|Shigellosis|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection|Transcriptional misregulation in cancer|MicroRNAs in cancer ATMIN 1565.718253 1602.237379 1529.199126 0.954414836 -0.067311625 0.779592618 1 16.57461992 15.55435255 23300 ATM interactor "GO:0000976,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0006974,GO:0016604,GO:0044458,GO:0045893,GO:0045944,GO:0046872,GO:0070840,GO:1902857" "transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|nuclear body|motile cilium assembly|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|dynein complex binding|positive regulation of non-motile cilium assembly" ATN1 2443.416688 2489.710421 2397.122954 0.962811953 -0.054674042 0.818510819 1 27.79152254 26.31025105 1822 atrophin 1 "GO:0000122,GO:0001085,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007417,GO:0016363,GO:0019904,GO:0030054,GO:0048471,GO:0051402" negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription factor binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|central nervous system development|nuclear matrix|protein domain specific binding|cell junction|perinuclear region of cytoplasm|neuron apoptotic process ATOH1 2.601034707 5.202069413 0 0 #NAME? 0.147074026 1 0.125508537 0 474 atonal bHLH transcription factor 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001764,GO:0003700,GO:0005634,GO:0006357,GO:0006366,GO:0007219,GO:0007411,GO:0007417,GO:0021987,GO:0030182,GO:0031490,GO:0042472,GO:0042667,GO:0042668,GO:0043066,GO:0045609,GO:0045666,GO:0045944,GO:0046983,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|neuron migration|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|Notch signaling pathway|axon guidance|central nervous system development|cerebral cortex development|neuron differentiation|chromatin DNA binding|inner ear morphogenesis|auditory receptor cell fate specification|auditory receptor cell fate determination|negative regulation of apoptotic process|positive regulation of inner ear auditory receptor cell differentiation|positive regulation of neuron differentiation|positive regulation of transcription by RNA polymerase II|protein dimerization activity|sequence-specific double-stranded DNA binding" bHLH ATOH7 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.073107277 0.099611795 220202 atonal bHLH transcription factor 7 "GO:0000785,GO:0000978,GO:0000981,GO:0003407,GO:0005515,GO:0005634,GO:0006357,GO:0007623,GO:0021554,GO:0030182,GO:0043153,GO:0046983,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|neural retina development|protein binding|nucleus|regulation of transcription by RNA polymerase II|circadian rhythm|optic nerve development|neuron differentiation|entrainment of circadian clock by photoperiod|protein dimerization activity|sequence-specific double-stranded DNA binding" ATOH8 8.045908318 9.363724944 6.728091692 0.718527267 -0.476885189 0.786592357 1 0.076798031 0.054258092 84913 atonal bHLH transcription factor 8 "GO:0000785,GO:0000978,GO:0000981,GO:0001704,GO:0001937,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0010595,GO:0010629,GO:0016607,GO:0030182,GO:0033613,GO:0035148,GO:0045603,GO:0045892,GO:0045893,GO:0046983,GO:0051450,GO:0060395,GO:0070888,GO:1902895" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|formation of primary germ layer|negative regulation of endothelial cell proliferation|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|positive regulation of endothelial cell migration|negative regulation of gene expression|nuclear speck|neuron differentiation|activating transcription factor binding|tube formation|positive regulation of endothelial cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein dimerization activity|myoblast proliferation|SMAD protein signal transduction|E-box binding|positive regulation of pri-miRNA transcription by RNA polymerase II" ATOX1 851.3616099 751.1788233 951.5443964 1.266734853 0.341114578 0.172213936 1 85.11472015 106.013598 475 antioxidant 1 copper chaperone "GO:0005507,GO:0005515,GO:0005829,GO:0006825,GO:0006878,GO:0006979,GO:0016530,GO:0016531,GO:0032767" copper ion binding|protein binding|cytosol|copper ion transport|cellular copper ion homeostasis|response to oxidative stress|metallochaperone activity|copper chaperone activity|copper-dependent protein binding hsa04978 Mineral absorption ATP10D 552.7006174 606.5612936 498.8399412 0.822406485 -0.282076455 0.291955878 1 5.233801362 4.232285344 57205 ATPase phospholipid transporting 10D (putative) "GO:0000287,GO:0005515,GO:0005524,GO:0005654,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0006812,GO:0016021,GO:0034220,GO:0045332,GO:0140326,GO:0140351,GO:1990531" magnesium ion binding|protein binding|ATP binding|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|cation transport|integral component of membrane|ion transmembrane transport|phospholipid translocation|ATPase-coupled intramembrane lipid transporter activity|glycosylceramide flippase activity|phospholipid-translocating ATPase complex ATP11A 1200.911721 1323.406459 1078.416983 0.814879643 -0.295341105 0.222547918 1 7.434502146 5.956848273 23250 ATPase phospholipid transporting 11A "GO:0000287,GO:0005515,GO:0005524,GO:0005765,GO:0005769,GO:0005783,GO:0005802,GO:0005886,GO:0005887,GO:0016020,GO:0035579,GO:0043231,GO:0043312,GO:0045332,GO:0055037,GO:0070821,GO:0090555,GO:0140326,GO:0140331,GO:0140346,GO:1990531" magnesium ion binding|protein binding|ATP binding|lysosomal membrane|early endosome|endoplasmic reticulum|trans-Golgi network|plasma membrane|integral component of plasma membrane|membrane|specific granule membrane|intracellular membrane-bounded organelle|neutrophil degranulation|phospholipid translocation|recycling endosome|tertiary granule membrane|phosphatidylethanolamine flippase activity|ATPase-coupled intramembrane lipid transporter activity|aminophospholipid translocation|phosphatidylserine flippase activity|phospholipid-translocating ATPase complex ATP11B 1946.017136 1896.674508 1995.359765 1.052030676 0.073176772 0.758843515 1 13.16795012 13.6212748 23200 ATPase phospholipid transporting 11B (putative) "GO:0000287,GO:0005515,GO:0005524,GO:0005637,GO:0005769,GO:0005783,GO:0005802,GO:0005886,GO:0006811,GO:0015075,GO:0015917,GO:0016020,GO:0016021,GO:0034220,GO:0035577,GO:0043312,GO:0045332,GO:0055037,GO:0055038,GO:0140326" magnesium ion binding|protein binding|ATP binding|nuclear inner membrane|early endosome|endoplasmic reticulum|trans-Golgi network|plasma membrane|ion transport|ion transmembrane transporter activity|aminophospholipid transport|membrane|integral component of membrane|ion transmembrane transport|azurophil granule membrane|neutrophil degranulation|phospholipid translocation|recycling endosome|recycling endosome membrane|ATPase-coupled intramembrane lipid transporter activity ATP11C 1632.00906 1475.306886 1788.711234 1.212433326 0.277905413 0.242679711 1 10.2853582 12.26163728 286410 ATPase phospholipid transporting 11C "GO:0000287,GO:0002329,GO:0005515,GO:0005524,GO:0005765,GO:0005783,GO:0005789,GO:0005802,GO:0005886,GO:0005887,GO:0034220,GO:0045332,GO:0045579,GO:0055037,GO:0090555,GO:0140326,GO:0140331,GO:0140346" magnesium ion binding|pre-B cell differentiation|protein binding|ATP binding|lysosomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|trans-Golgi network|plasma membrane|integral component of plasma membrane|ion transmembrane transport|phospholipid translocation|positive regulation of B cell differentiation|recycling endosome|phosphatidylethanolamine flippase activity|ATPase-coupled intramembrane lipid transporter activity|aminophospholipid translocation|phosphatidylserine flippase activity ATP13A1 629.6471997 671.0669543 588.2274451 0.876555523 -0.190082618 0.467819692 1 9.304653152 8.01956474 57130 ATPase 13A1 "GO:0003674,GO:0005524,GO:0005789,GO:0006874,GO:0008150,GO:0015410,GO:0016020,GO:0016021,GO:0016887,GO:0034220,GO:0046872,GO:0071421" "molecular_function|ATP binding|endoplasmic reticulum membrane|cellular calcium ion homeostasis|biological_process|manganese transmembrane transporter activity, phosphorylative mechanism|membrane|integral component of membrane|ATPase activity|ion transmembrane transport|metal ion binding|manganese ion transmembrane transport" ATP13A2 955.0067085 948.857461 961.155956 1.012961373 0.018579161 0.944578026 1 12.67236706 12.62181491 23400 ATPase cation transporting 13A2 "GO:0000421,GO:0005515,GO:0005524,GO:0005764,GO:0005765,GO:0005770,GO:0005771,GO:0005776,GO:0006874,GO:0006879,GO:0006882,GO:0006914,GO:0007041,GO:0008270,GO:0010628,GO:0010821,GO:0012506,GO:0016021,GO:0016241,GO:0016243,GO:0016887,GO:0019829,GO:0030003,GO:0030133,GO:0030145,GO:0031982,GO:0032585,GO:0033157,GO:0034220,GO:0034599,GO:0043005,GO:0043025,GO:0043202,GO:0046777,GO:0050714,GO:0052548,GO:0055069,GO:0055088,GO:0061462,GO:0061909,GO:0070300,GO:0071287,GO:0071294,GO:0080025,GO:0097734,GO:1900180,GO:1901215,GO:1902047,GO:1903135,GO:1903146,GO:1903543,GO:1903710,GO:1904714,GO:1905037,GO:1905103,GO:1905123,GO:1905165,GO:1905166,GO:1990938,GO:2000152" "autophagosome membrane|protein binding|ATP binding|lysosome|lysosomal membrane|late endosome|multivesicular body|autophagosome|cellular calcium ion homeostasis|cellular iron ion homeostasis|cellular zinc ion homeostasis|autophagy|lysosomal transport|zinc ion binding|positive regulation of gene expression|regulation of mitochondrion organization|vesicle membrane|integral component of membrane|regulation of macroautophagy|regulation of autophagosome size|ATPase activity|ATPase-coupled cation transmembrane transporter activity|cellular cation homeostasis|transport vesicle|manganese ion binding|vesicle|multivesicular body membrane|regulation of intracellular protein transport|ion transmembrane transport|cellular response to oxidative stress|neuron projection|neuronal cell body|lysosomal lumen|protein autophosphorylation|positive regulation of protein secretion|regulation of endopeptidase activity|zinc ion homeostasis|lipid homeostasis|protein localization to lysosome|autophagosome-lysosome fusion|phosphatidic acid binding|cellular response to manganese ion|cellular response to zinc ion|phosphatidylinositol-3,5-bisphosphate binding|extracellular exosome biogenesis|regulation of protein localization to nucleus|negative regulation of neuron death|polyamine transmembrane transport|cupric ion binding|regulation of autophagy of mitochondrion|positive regulation of exosomal secretion|spermine transmembrane transport|regulation of chaperone-mediated autophagy|autophagosome organization|integral component of lysosomal membrane|regulation of glucosylceramidase activity|regulation of lysosomal protein catabolic process|negative regulation of lysosomal protein catabolic process|peptidyl-aspartic acid autophosphorylation|regulation of ubiquitin-specific protease activity" ATP13A3 6228.588428 6417.272828 6039.904027 0.941194833 -0.087434695 0.71897157 1 31.51541883 29.16579346 79572 ATPase 13A3 "GO:0005524,GO:0006812,GO:0006874,GO:0016020,GO:0016021,GO:0016887,GO:0046872" ATP binding|cation transport|cellular calcium ion homeostasis|membrane|integral component of membrane|ATPase activity|metal ion binding ATP1A1 14395.56891 14770.75589 14020.38193 0.949198676 -0.075218007 0.773514707 1 110.3890344 103.027755 476 ATPase Na+/K+ transporting subunit alpha 1 "GO:0002026,GO:0002028,GO:0005391,GO:0005515,GO:0005524,GO:0005768,GO:0005783,GO:0005794,GO:0005886,GO:0005890,GO:0005901,GO:0006883,GO:0008217,GO:0010248,GO:0014069,GO:0014704,GO:0016020,GO:0016021,GO:0016311,GO:0016323,GO:0016324,GO:0016328,GO:0016791,GO:0019901,GO:0019904,GO:0030007,GO:0030315,GO:0030506,GO:0030955,GO:0031090,GO:0031402,GO:0031947,GO:0032991,GO:0034220,GO:0036126,GO:0036376,GO:0042383,GO:0042470,GO:0042493,GO:0043531,GO:0043548,GO:0045121,GO:0045822,GO:0045823,GO:0045989,GO:0046982,GO:0051087,GO:0055119,GO:0060081,GO:0060342,GO:0070062,GO:0071260,GO:0071383,GO:0086002,GO:0086004,GO:0086009,GO:0086013,GO:0086064,GO:1902600,GO:1903416,GO:1903561,GO:1903779,GO:1990239,GO:1990573" regulation of the force of heart contraction|regulation of sodium ion transport|sodium:potassium-exchanging ATPase activity|protein binding|ATP binding|endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|sodium:potassium-exchanging ATPase complex|caveola|cellular sodium ion homeostasis|regulation of blood pressure|establishment or maintenance of transmembrane electrochemical gradient|postsynaptic density|intercalated disc|membrane|integral component of membrane|dephosphorylation|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|phosphatase activity|protein kinase binding|protein domain specific binding|cellular potassium ion homeostasis|T-tubule|ankyrin binding|potassium ion binding|organelle membrane|sodium ion binding|negative regulation of glucocorticoid biosynthetic process|protein-containing complex|ion transmembrane transport|sperm flagellum|sodium ion export across plasma membrane|sarcolemma|melanosome|response to drug|ADP binding|phosphatidylinositol 3-kinase binding|membrane raft|negative regulation of heart contraction|positive regulation of heart contraction|positive regulation of striated muscle contraction|protein heterodimerization activity|chaperone binding|relaxation of cardiac muscle|membrane hyperpolarization|photoreceptor inner segment membrane|extracellular exosome|cellular response to mechanical stimulus|cellular response to steroid hormone stimulus|cardiac muscle cell action potential involved in contraction|regulation of cardiac muscle cell contraction|membrane repolarization|membrane repolarization during cardiac muscle cell action potential|cell communication by electrical coupling involved in cardiac conduction|proton transmembrane transport|response to glycoside|extracellular vesicle|regulation of cardiac conduction|steroid hormone binding|potassium ion import across plasma membrane "hsa04022,hsa04024,hsa04260,hsa04261,hsa04911,hsa04918,hsa04919,hsa04925,hsa04960,hsa04961,hsa04964,hsa04970,hsa04971,hsa04972,hsa04973,hsa04974,hsa04976,hsa04978" cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Insulin secretion|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Aldosterone synthesis and secretion|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Proximal tubule bicarbonate reclamation|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Protein digestion and absorption|Bile secretion|Mineral absorption ATP1A3 73.19127725 41.61655531 104.7659992 2.517411603 1.33194112 0.011772444 0.643952702 0.612520427 1.516163317 478 ATPase Na+/K+ transporting subunit alpha 3 "GO:0001540,GO:0001917,GO:0005391,GO:0005515,GO:0005524,GO:0005783,GO:0005794,GO:0005886,GO:0005890,GO:0006883,GO:0010248,GO:0016020,GO:0016021,GO:0030007,GO:0030424,GO:0031090,GO:0032809,GO:0034220,GO:0036376,GO:0043025,GO:0045202,GO:0046872,GO:0051087,GO:0060075,GO:0060342,GO:0071383,GO:0086064,GO:0098984,GO:0099520,GO:1902600,GO:1903416,GO:1903561,GO:1903779,GO:1904646,GO:1990239,GO:1990535,GO:1990573" amyloid-beta binding|photoreceptor inner segment|sodium:potassium-exchanging ATPase activity|protein binding|ATP binding|endoplasmic reticulum|Golgi apparatus|plasma membrane|sodium:potassium-exchanging ATPase complex|cellular sodium ion homeostasis|establishment or maintenance of transmembrane electrochemical gradient|membrane|integral component of membrane|cellular potassium ion homeostasis|axon|organelle membrane|neuronal cell body membrane|ion transmembrane transport|sodium ion export across plasma membrane|neuronal cell body|synapse|metal ion binding|chaperone binding|regulation of resting membrane potential|photoreceptor inner segment membrane|cellular response to steroid hormone stimulus|cell communication by electrical coupling involved in cardiac conduction|neuron to neuron synapse|ion antiporter activity involved in regulation of presynaptic membrane potential|proton transmembrane transport|response to glycoside|extracellular vesicle|regulation of cardiac conduction|cellular response to amyloid-beta|steroid hormone binding|neuron projection maintenance|potassium ion import across plasma membrane "hsa04022,hsa04024,hsa04260,hsa04261,hsa04911,hsa04918,hsa04919,hsa04925,hsa04960,hsa04961,hsa04964,hsa04970,hsa04971,hsa04972,hsa04973,hsa04974,hsa04976,hsa04978" cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Insulin secretion|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Aldosterone synthesis and secretion|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Proximal tubule bicarbonate reclamation|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Protein digestion and absorption|Bile secretion|Mineral absorption ATP1B1 1853.711566 1883.149128 1824.274004 0.968735815 -0.045824815 0.848685398 1 45.35207936 43.19900449 481 ATPase Na+/K+ transporting subunit beta 1 "GO:0001666,GO:0001671,GO:0005515,GO:0005886,GO:0005890,GO:0005901,GO:0006874,GO:0006883,GO:0007155,GO:0008022,GO:0010248,GO:0010468,GO:0010882,GO:0014704,GO:0016020,GO:0016323,GO:0016324,GO:0016328,GO:0019901,GO:0023026,GO:0030007,GO:0030315,GO:0030674,GO:0031090,GO:0032781,GO:0034220,GO:0035725,GO:0036126,GO:0036376,GO:0042383,GO:0044861,GO:0046034,GO:0046982,GO:0050821,GO:0050900,GO:0051117,GO:0055119,GO:0060048,GO:0070062,GO:0072659,GO:0086009,GO:0086013,GO:0086064,GO:0098655,GO:1901018,GO:1903278,GO:1903281,GO:1903288,GO:1903408,GO:1903561,GO:1903779,GO:1990573" response to hypoxia|ATPase activator activity|protein binding|plasma membrane|sodium:potassium-exchanging ATPase complex|caveola|cellular calcium ion homeostasis|cellular sodium ion homeostasis|cell adhesion|protein C-terminus binding|establishment or maintenance of transmembrane electrochemical gradient|regulation of gene expression|regulation of cardiac muscle contraction by calcium ion signaling|intercalated disc|membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|protein kinase binding|MHC class II protein complex binding|cellular potassium ion homeostasis|T-tubule|protein-macromolecule adaptor activity|organelle membrane|positive regulation of ATPase activity|ion transmembrane transport|sodium ion transmembrane transport|sperm flagellum|sodium ion export across plasma membrane|sarcolemma|protein transport into plasma membrane raft|ATP metabolic process|protein heterodimerization activity|protein stabilization|leukocyte migration|ATPase binding|relaxation of cardiac muscle|cardiac muscle contraction|extracellular exosome|protein localization to plasma membrane|membrane repolarization|membrane repolarization during cardiac muscle cell action potential|cell communication by electrical coupling involved in cardiac conduction|cation transmembrane transport|positive regulation of potassium ion transmembrane transporter activity|positive regulation of sodium ion export across plasma membrane|positive regulation of calcium:sodium antiporter activity|positive regulation of potassium ion import across plasma membrane|positive regulation of sodium:potassium-exchanging ATPase activity|extracellular vesicle|regulation of cardiac conduction|potassium ion import across plasma membrane "hsa04022,hsa04024,hsa04260,hsa04261,hsa04911,hsa04918,hsa04919,hsa04925,hsa04960,hsa04961,hsa04964,hsa04970,hsa04971,hsa04972,hsa04973,hsa04974,hsa04976,hsa04978" cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Insulin secretion|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Aldosterone synthesis and secretion|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Proximal tubule bicarbonate reclamation|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Protein digestion and absorption|Bile secretion|Mineral absorption ATP1B3 2654.077804 2569.82229 2738.333319 1.065573028 0.09162947 0.69935423 1 74.25375879 77.79878964 483 ATPase Na+/K+ transporting subunit beta 3 "GO:0001671,GO:0005515,GO:0005886,GO:0005890,GO:0005901,GO:0006883,GO:0010248,GO:0030007,GO:0030674,GO:0032781,GO:0034220,GO:0035725,GO:0036126,GO:0036376,GO:0042470,GO:0050821,GO:0050900,GO:0051117,GO:0070062,GO:0071805,GO:0072659,GO:0086009,GO:1901018,GO:1903278,GO:1903288,GO:1903779,GO:1990573" ATPase activator activity|protein binding|plasma membrane|sodium:potassium-exchanging ATPase complex|caveola|cellular sodium ion homeostasis|establishment or maintenance of transmembrane electrochemical gradient|cellular potassium ion homeostasis|protein-macromolecule adaptor activity|positive regulation of ATPase activity|ion transmembrane transport|sodium ion transmembrane transport|sperm flagellum|sodium ion export across plasma membrane|melanosome|protein stabilization|leukocyte migration|ATPase binding|extracellular exosome|potassium ion transmembrane transport|protein localization to plasma membrane|membrane repolarization|positive regulation of potassium ion transmembrane transporter activity|positive regulation of sodium ion export across plasma membrane|positive regulation of potassium ion import across plasma membrane|regulation of cardiac conduction|potassium ion import across plasma membrane "hsa04022,hsa04024,hsa04260,hsa04261,hsa04911,hsa04918,hsa04919,hsa04925,hsa04960,hsa04961,hsa04964,hsa04970,hsa04971,hsa04972,hsa04973,hsa04974,hsa04976,hsa04978" cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Insulin secretion|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Aldosterone synthesis and secretion|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Proximal tubule bicarbonate reclamation|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Protein digestion and absorption|Bile secretion|Mineral absorption ATP23 179.6757988 149.8195991 209.5319984 1.398562002 0.483944213 0.202177194 1 5.694869407 7.831350694 91419 ATP23 metallopeptidase and ATP synthase assembly factor homolog "GO:0004222,GO:0004677,GO:0005515,GO:0005829,GO:0005886,GO:0005958,GO:0006303,GO:0006468,GO:0030054,GO:0031314,GO:0033615,GO:0034982,GO:0043231,GO:0046872" metalloendopeptidase activity|DNA-dependent protein kinase activity|protein binding|cytosol|plasma membrane|DNA-dependent protein kinase-DNA ligase 4 complex|double-strand break repair via nonhomologous end joining|protein phosphorylation|cell junction|extrinsic component of mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial protein processing|intracellular membrane-bounded organelle|metal ion binding ATP2A1 59.60614614 63.46524684 55.74704545 0.878386963 -0.187071452 0.762940589 1 0.955436835 0.825199661 487 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 "GO:0005388,GO:0005509,GO:0005515,GO:0005524,GO:0005739,GO:0005789,GO:0006816,GO:0006874,GO:0008553,GO:0008637,GO:0016021,GO:0016529,GO:0016887,GO:0030899,GO:0031095,GO:0031448,GO:0032470,GO:0032471,GO:0033017,GO:0034220,GO:0034704,GO:0034976,GO:0042803,GO:0051561,GO:0051659,GO:0070059,GO:0070509,GO:0070588,GO:0090076,GO:0106134,GO:1901896,GO:1902082,GO:1902600,GO:1903779,GO:1990036" "calcium transmembrane transporter activity, phosphorylative mechanism|calcium ion binding|protein binding|ATP binding|mitochondrion|endoplasmic reticulum membrane|calcium ion transport|cellular calcium ion homeostasis|proton-exporting ATPase activity, phosphorylative mechanism|apoptotic mitochondrial changes|integral component of membrane|sarcoplasmic reticulum|ATPase activity|calcium-dependent ATPase activity|platelet dense tubular network membrane|positive regulation of fast-twitch skeletal muscle fiber contraction|positive regulation of endoplasmic reticulum calcium ion concentration|negative regulation of endoplasmic reticulum calcium ion concentration|sarcoplasmic reticulum membrane|ion transmembrane transport|calcium channel complex|response to endoplasmic reticulum stress|protein homodimerization activity|positive regulation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|calcium ion import|calcium ion transmembrane transport|relaxation of skeletal muscle|positive regulation of cardiac muscle cell contraction|positive regulation of ATPase-coupled calcium transmembrane transporter activity|positive regulation of calcium ion import into sarcoplasmic reticulum|proton transmembrane transport|regulation of cardiac conduction|calcium ion import into sarcoplasmic reticulum" "hsa04020,hsa04022,hsa04024,hsa04260,hsa04261,hsa04919,hsa04972,hsa05010,hsa05017,hsa05022,hsa05410,hsa05412,hsa05414" Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Thyroid hormone signaling pathway|Pancreatic secretion|Alzheimer disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ATP2A2 7362.279597 7590.859688 7133.699505 0.939774913 -0.089612838 0.715067177 1 63.50685533 58.68344952 488 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 "GO:0002026,GO:0003009,GO:0005388,GO:0005509,GO:0005515,GO:0005524,GO:0005783,GO:0005789,GO:0005887,GO:0006874,GO:0006984,GO:0006996,GO:0007155,GO:0008544,GO:0008553,GO:0010460,GO:0010882,GO:0012506,GO:0014883,GO:0014898,GO:0016020,GO:0016529,GO:0016887,GO:0019899,GO:0031095,GO:0031234,GO:0031775,GO:0032469,GO:0032470,GO:0032496,GO:0032991,GO:0033017,GO:0033292,GO:0034220,GO:0034599,GO:0034605,GO:0034976,GO:0044325,GO:0044548,GO:0045822,GO:0048471,GO:0055119,GO:0061831,GO:0070296,GO:0070588,GO:0086036,GO:0086039,GO:0097470,GO:0098909,GO:0120025,GO:1900121,GO:1902600,GO:1903233,GO:1903515,GO:1903779,GO:1990036" "regulation of the force of heart contraction|skeletal muscle contraction|calcium transmembrane transporter activity, phosphorylative mechanism|calcium ion binding|protein binding|ATP binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of plasma membrane|cellular calcium ion homeostasis|ER-nucleus signaling pathway|organelle organization|cell adhesion|epidermis development|proton-exporting ATPase activity, phosphorylative mechanism|positive regulation of heart rate|regulation of cardiac muscle contraction by calcium ion signaling|vesicle membrane|transition between fast and slow fiber|cardiac muscle hypertrophy in response to stress|membrane|sarcoplasmic reticulum|ATPase activity|enzyme binding|platelet dense tubular network membrane|extrinsic component of cytoplasmic side of plasma membrane|lutropin-choriogonadotropic hormone receptor binding|endoplasmic reticulum calcium ion homeostasis|positive regulation of endoplasmic reticulum calcium ion concentration|response to lipopolysaccharide|protein-containing complex|sarcoplasmic reticulum membrane|T-tubule organization|ion transmembrane transport|cellular response to oxidative stress|cellular response to heat|response to endoplasmic reticulum stress|ion channel binding|S100 protein binding|negative regulation of heart contraction|perinuclear region of cytoplasm|relaxation of cardiac muscle|apical ectoplasmic specialization|sarcoplasmic reticulum calcium ion transport|calcium ion transmembrane transport|regulation of cardiac muscle cell membrane potential|calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential|ribbon synapse|regulation of cardiac muscle cell action potential involved in regulation of contraction|plasma membrane bounded cell projection|negative regulation of receptor binding|proton transmembrane transport|regulation of calcium ion-dependent exocytosis of neurotransmitter|calcium ion transport from cytosol to endoplasmic reticulum|regulation of cardiac conduction|calcium ion import into sarcoplasmic reticulum" "hsa04020,hsa04022,hsa04024,hsa04260,hsa04261,hsa04919,hsa04972,hsa05010,hsa05017,hsa05022,hsa05410,hsa05412,hsa05414" Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Thyroid hormone signaling pathway|Pancreatic secretion|Alzheimer disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ATP2A3 13.1687198 17.687036 8.650403604 0.489081585 -1.03185295 0.321609015 1 0.14571235 0.0700727 489 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 "GO:0005388,GO:0005524,GO:0005783,GO:0005789,GO:0006816,GO:0006874,GO:0006919,GO:0008553,GO:0008656,GO:0015085,GO:0016021,GO:0016529,GO:0016887,GO:0030899,GO:0031090,GO:0031095,GO:0031965,GO:0033017,GO:0034220,GO:0044325,GO:0046872,GO:0070059,GO:0070588,GO:0150104,GO:1900121,GO:1902600,GO:1903515,GO:1903779" "calcium transmembrane transporter activity, phosphorylative mechanism|ATP binding|endoplasmic reticulum|endoplasmic reticulum membrane|calcium ion transport|cellular calcium ion homeostasis|activation of cysteine-type endopeptidase activity involved in apoptotic process|proton-exporting ATPase activity, phosphorylative mechanism|cysteine-type endopeptidase activator activity involved in apoptotic process|calcium ion transmembrane transporter activity|integral component of membrane|sarcoplasmic reticulum|ATPase activity|calcium-dependent ATPase activity|organelle membrane|platelet dense tubular network membrane|nuclear membrane|sarcoplasmic reticulum membrane|ion transmembrane transport|ion channel binding|metal ion binding|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|calcium ion transmembrane transport|transport across blood-brain barrier|negative regulation of receptor binding|proton transmembrane transport|calcium ion transport from cytosol to endoplasmic reticulum|regulation of cardiac conduction" "hsa04020,hsa04022,hsa04024,hsa04260,hsa04261,hsa04919,hsa04972,hsa05010,hsa05017,hsa05022,hsa05410,hsa05412,hsa05414" Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Thyroid hormone signaling pathway|Pancreatic secretion|Alzheimer disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ATP2B1 3748.087363 4026.401726 3469.773001 0.861755294 -0.214649839 0.366648936 1 27.68736759 23.46047523 490 ATPase plasma membrane Ca2+ transporting 1 "GO:0001772,GO:0001818,GO:0003056,GO:0003407,GO:0005388,GO:0005515,GO:0005516,GO:0005524,GO:0005654,GO:0005886,GO:0005887,GO:0006874,GO:0007420,GO:0007568,GO:0008217,GO:0009409,GO:0009898,GO:0015085,GO:0016020,GO:0016323,GO:0016324,GO:0016887,GO:0019829,GO:0030165,GO:0030501,GO:0032591,GO:0032809,GO:0034220,GO:0043231,GO:0045121,GO:0046872,GO:0051480,GO:0051481,GO:0051928,GO:0070062,GO:0071305,GO:0071386,GO:0098978,GO:0098982,GO:0099059,GO:0099509,GO:1900076,GO:1903779,GO:1905056,GO:1990034" "immunological synapse|negative regulation of cytokine production|regulation of vascular associated smooth muscle contraction|neural retina development|calcium transmembrane transporter activity, phosphorylative mechanism|protein binding|calmodulin binding|ATP binding|nucleoplasm|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|brain development|aging|regulation of blood pressure|response to cold|cytoplasmic side of plasma membrane|calcium ion transmembrane transporter activity|membrane|basolateral plasma membrane|apical plasma membrane|ATPase activity|ATPase-coupled cation transmembrane transporter activity|PDZ domain binding|positive regulation of bone mineralization|dendritic spine membrane|neuronal cell body membrane|ion transmembrane transport|intracellular membrane-bounded organelle|membrane raft|metal ion binding|regulation of cytosolic calcium ion concentration|negative regulation of cytosolic calcium ion concentration|positive regulation of calcium ion transport|extracellular exosome|cellular response to vitamin D|cellular response to corticosterone stimulus|glutamatergic synapse|GABA-ergic synapse|integral component of presynaptic active zone membrane|regulation of presynaptic cytosolic calcium ion concentration|regulation of cellular response to insulin stimulus|regulation of cardiac conduction|calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration|calcium ion export across plasma membrane" "hsa04020,hsa04022,hsa04024,hsa04261,hsa04925,hsa04961,hsa04970,hsa04972,hsa04978" Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Adrenergic signaling in cardiomyocytes|Aldosterone synthesis and secretion|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Pancreatic secretion|Mineral absorption ATP2B4 4909.931915 4803.590896 5016.272934 1.044275635 0.06250256 0.79503942 1 27.71746324 28.46032165 493 ATPase plasma membrane Ca2+ transporting 4 "GO:0003407,GO:0005388,GO:0005515,GO:0005516,GO:0005524,GO:0005886,GO:0005887,GO:0005901,GO:0006357,GO:0006874,GO:0007283,GO:0010629,GO:0010751,GO:0014832,GO:0015085,GO:0016020,GO:0016323,GO:0016525,GO:0017080,GO:0019829,GO:0019901,GO:0021766,GO:0030018,GO:0030165,GO:0030315,GO:0030317,GO:0030346,GO:0032991,GO:0033138,GO:0034220,GO:0036126,GO:0036487,GO:0043005,GO:0043231,GO:0043537,GO:0045019,GO:0045121,GO:0046872,GO:0048306,GO:0050998,GO:0051001,GO:0051480,GO:0051599,GO:0070588,GO:0070885,GO:0071872,GO:0097110,GO:0097228,GO:0097553,GO:0098703,GO:0098736,GO:0098978,GO:0099059,GO:0140199,GO:0150104,GO:1900082,GO:1901660,GO:1902083,GO:1902305,GO:1902548,GO:1902806,GO:1903078,GO:1903243,GO:1903249,GO:1903779,GO:1905145,GO:2000481" "neural retina development|calcium transmembrane transporter activity, phosphorylative mechanism|protein binding|calmodulin binding|ATP binding|plasma membrane|integral component of plasma membrane|caveola|regulation of transcription by RNA polymerase II|cellular calcium ion homeostasis|spermatogenesis|negative regulation of gene expression|negative regulation of nitric oxide mediated signal transduction|urinary bladder smooth muscle contraction|calcium ion transmembrane transporter activity|membrane|basolateral plasma membrane|negative regulation of angiogenesis|sodium channel regulator activity|ATPase-coupled cation transmembrane transporter activity|protein kinase binding|hippocampus development|Z disc|PDZ domain binding|T-tubule|flagellated sperm motility|protein phosphatase 2B binding|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|ion transmembrane transport|sperm flagellum|nitric-oxide synthase inhibitor activity|neuron projection|intracellular membrane-bounded organelle|negative regulation of blood vessel endothelial cell migration|negative regulation of nitric oxide biosynthetic process|membrane raft|metal ion binding|calcium-dependent protein binding|nitric-oxide synthase binding|negative regulation of nitric-oxide synthase activity|regulation of cytosolic calcium ion concentration|response to hydrostatic pressure|calcium ion transmembrane transport|negative regulation of calcineurin-NFAT signaling cascade|cellular response to epinephrine stimulus|scaffold protein binding|sperm principal piece|calcium ion transmembrane import into cytosol|calcium ion import across plasma membrane|negative regulation of the force of heart contraction|glutamatergic synapse|integral component of presynaptic active zone membrane|negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process|transport across blood-brain barrier|negative regulation of arginine catabolic process|calcium ion export|negative regulation of peptidyl-cysteine S-nitrosylation|regulation of sodium ion transmembrane transport|negative regulation of cellular response to vascular endothelial growth factor stimulus|regulation of cell cycle G1/S phase transition|positive regulation of protein localization to plasma membrane|negative regulation of cardiac muscle hypertrophy in response to stress|negative regulation of citrulline biosynthetic process|regulation of cardiac conduction|cellular response to acetylcholine|positive regulation of cAMP-dependent protein kinase activity" "hsa04020,hsa04022,hsa04024,hsa04261,hsa04925,hsa04961,hsa04970,hsa04972,hsa04978" Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Adrenergic signaling in cardiomyocytes|Aldosterone synthesis and secretion|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Pancreatic secretion|Mineral absorption ATP2C1 2999.768815 3078.584679 2920.95295 0.948797339 -0.075828132 0.749688948 1 39.07215365 36.45121313 27032 ATPase secretory pathway Ca2+ transporting 1 "GO:0000139,GO:0005388,GO:0005524,GO:0005783,GO:0005794,GO:0005802,GO:0005886,GO:0006816,GO:0006828,GO:0006874,GO:0008544,GO:0008553,GO:0015410,GO:0016020,GO:0016021,GO:0016339,GO:0016887,GO:0031532,GO:0032468,GO:0032472,GO:0034220,GO:0043123,GO:0046872,GO:0070588,GO:0071421,GO:1902600" "Golgi membrane|calcium transmembrane transporter activity, phosphorylative mechanism|ATP binding|endoplasmic reticulum|Golgi apparatus|trans-Golgi network|plasma membrane|calcium ion transport|manganese ion transport|cellular calcium ion homeostasis|epidermis development|proton-exporting ATPase activity, phosphorylative mechanism|manganese transmembrane transporter activity, phosphorylative mechanism|membrane|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|ATPase activity|actin cytoskeleton reorganization|Golgi calcium ion homeostasis|Golgi calcium ion transport|ion transmembrane transport|positive regulation of I-kappaB kinase/NF-kappaB signaling|metal ion binding|calcium ion transmembrane transport|manganese ion transmembrane transport|proton transmembrane transport" ATP5F1A 7880.738332 7702.183973 8059.292691 1.046364605 0.065385645 0.791090066 1 64.2167478 66.06972914 498 ATP synthase F1 subunit alpha "GO:0001937,GO:0003723,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0005753,GO:0005759,GO:0005886,GO:0006629,GO:0006754,GO:0008180,GO:0015986,GO:0016020,GO:0016887,GO:0042288,GO:0042407,GO:0042776,GO:0043531,GO:0043532,GO:0043536,GO:0045259,GO:0045261,GO:0046933,GO:0070062" "negative regulation of endothelial cell proliferation|RNA binding|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|mitochondrial matrix|plasma membrane|lipid metabolic process|ATP biosynthetic process|COP9 signalosome|ATP synthesis coupled proton transport|membrane|ATPase activity|MHC class I protein binding|cristae formation|mitochondrial ATP synthesis coupled proton transport|ADP binding|angiostatin binding|positive regulation of blood vessel endothelial cell migration|proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, catalytic core F(1)|proton-transporting ATP synthase activity, rotational mechanism|extracellular exosome" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5F1B 12182.16848 11834.70792 12529.62904 1.058718908 0.082319602 0.74820175 1 359.0657249 373.7883823 506 ATP synthase F1 subunit beta "GO:0001525,GO:0001649,GO:0005515,GO:0005524,GO:0005634,GO:0005739,GO:0005753,GO:0005754,GO:0005759,GO:0005886,GO:0006091,GO:0006629,GO:0006754,GO:0006933,GO:0007005,GO:0009986,GO:0016020,GO:0016887,GO:0031966,GO:0042288,GO:0042407,GO:0042645,GO:0042776,GO:0043532,GO:0043536,GO:0045259,GO:0045261,GO:0046933,GO:0046961,GO:0051453,GO:0070062,GO:0098761,GO:1902600" "angiogenesis|osteoblast differentiation|protein binding|ATP binding|nucleus|mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase, catalytic core|mitochondrial matrix|plasma membrane|generation of precursor metabolites and energy|lipid metabolic process|ATP biosynthetic process|negative regulation of cell adhesion involved in substrate-bound cell migration|mitochondrion organization|cell surface|membrane|ATPase activity|mitochondrial membrane|MHC class I protein binding|cristae formation|mitochondrial nucleoid|mitochondrial ATP synthesis coupled proton transport|angiostatin binding|positive regulation of blood vessel endothelial cell migration|proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, catalytic core F(1)|proton-transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism|regulation of intracellular pH|extracellular exosome|cellular response to interleukin-7|proton transmembrane transport" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5F1C 2717.792729 2375.264894 3060.320564 1.288412325 0.365594366 0.122261542 1 113.2828613 143.5126749 509 ATP synthase F1 subunit gamma "GO:0000275,GO:0003723,GO:0005515,GO:0005739,GO:0005743,GO:0005753,GO:0005759,GO:0006119,GO:0006754,GO:0015986,GO:0016020,GO:0016887,GO:0042407,GO:0042776,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)|RNA binding|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|mitochondrial matrix|oxidative phosphorylation|ATP biosynthetic process|ATP synthesis coupled proton transport|membrane|ATPase activity|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5F1D 629.9201864 589.9146715 669.9257013 1.135631531 0.183494811 0.483677773 1 45.03957339 50.29246114 513 ATP synthase F1 subunit delta "GO:0000275,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0005753,GO:0005759,GO:0006119,GO:0006754,GO:0009060,GO:0015986,GO:0016887,GO:0033615,GO:0042407,GO:0042776,GO:0043531,GO:0046688,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|mitochondrial matrix|oxidative phosphorylation|ATP biosynthetic process|aerobic respiration|ATP synthesis coupled proton transport|ATPase activity|mitochondrial proton-transporting ATP synthase complex assembly|cristae formation|mitochondrial ATP synthesis coupled proton transport|ADP binding|response to copper ion|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5F1E 2709.147356 2362.779927 3055.514784 1.293186364 0.370930201 0.116902384 1 34.92997843 44.41509677 514 ATP synthase F1 subunit epsilon "GO:0000275,GO:0005515,GO:0005743,GO:0005753,GO:0005759,GO:0006754,GO:0016887,GO:0042407,GO:0042776,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)|protein binding|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|mitochondrial matrix|ATP biosynthetic process|ATPase activity|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5IF1 876.7183862 735.572615 1017.864157 1.383771142 0.468605359 0.059926014 1 67.79992839 92.24964064 93974 ATP synthase inhibitory factor subunit 1 "GO:0001525,GO:0001937,GO:0004857,GO:0005515,GO:0005516,GO:0005739,GO:0006091,GO:0006783,GO:0009986,GO:0019899,GO:0030218,GO:0032780,GO:0032991,GO:0042030,GO:0042802,GO:0042803,GO:0043532,GO:0051117,GO:0051346,GO:0051882,GO:0072593,GO:0140260,GO:1901030,GO:1903052,GO:1903214,GO:1903578,GO:1904925" angiogenesis|negative regulation of endothelial cell proliferation|enzyme inhibitor activity|protein binding|calmodulin binding|mitochondrion|generation of precursor metabolites and energy|heme biosynthetic process|cell surface|enzyme binding|erythrocyte differentiation|negative regulation of ATPase activity|protein-containing complex|ATPase inhibitor activity|identical protein binding|protein homodimerization activity|angiostatin binding|ATPase binding|negative regulation of hydrolase activity|mitochondrial depolarization|reactive oxygen species metabolic process|mitochondrial proton-transporting ATP synthase complex binding|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of proteolysis involved in cellular protein catabolic process|regulation of protein targeting to mitochondrion|regulation of ATP metabolic process|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization ATP5MC1 737.9558823 625.2887435 850.6230211 1.360368358 0.443997354 0.080820535 1 57.93491494 77.4939992 516 ATP synthase membrane subunit c locus 1 "GO:0000276,GO:0005515,GO:0005739,GO:0005743,GO:0005753,GO:0006754,GO:0008289,GO:0015986,GO:0016021,GO:0042407,GO:0042776,GO:0045263,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|lipid binding|ATP synthesis coupled proton transport|integral component of membrane|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase complex, coupling factor F(o)|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5MC2 3284.593654 2973.502877 3595.684431 1.209241955 0.27410294 0.247655516 1 61.5556181 73.1900564 517 ATP synthase membrane subunit c locus 2 "GO:0000276,GO:0005515,GO:0005741,GO:0006754,GO:0008289,GO:0015986,GO:0016021,GO:0042407,GO:0042776,GO:0045263,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|protein binding|mitochondrial outer membrane|ATP biosynthetic process|lipid binding|ATP synthesis coupled proton transport|integral component of membrane|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase complex, coupling factor F(o)|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5MC3 2598.412474 2168.222531 3028.602417 1.396813461 0.482139367 0.04163641 1 41.68373612 57.25009716 518 ATP synthase membrane subunit c locus 3 "GO:0000276,GO:0005741,GO:0006754,GO:0008289,GO:0015986,GO:0016021,GO:0042407,GO:0042776,GO:0045263,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|mitochondrial outer membrane|ATP biosynthetic process|lipid binding|ATP synthesis coupled proton transport|integral component of membrane|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase complex, coupling factor F(o)|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5ME 631.1342074 558.702255 703.5661598 1.259286415 0.33260645 0.202027113 1 98.40565181 121.847252 521 ATP synthase membrane subunit e "GO:0000276,GO:0005515,GO:0005739,GO:0005743,GO:0005753,GO:0006754,GO:0042407,GO:0042776,GO:0044877,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|cristae formation|mitochondrial ATP synthesis coupled proton transport|protein-containing complex binding|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714" Oxidative phosphorylation|Thermogenesis ATP5MF 224.3047697 211.2040182 237.4055211 1.124057786 0.168716204 0.635887371 1 25.44372522 28.12163154 9551 ATP synthase membrane subunit f "GO:0005634,GO:0005739,GO:0005743,GO:0005753,GO:0006754,GO:0016021,GO:0031965,GO:0042407,GO:0042776,GO:0045263,GO:0046933,GO:1902600" "nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|integral component of membrane|nuclear membrane|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase complex, coupling factor F(o)|proton-transporting ATP synthase activity, rotational mechanism|proton transmembrane transport" "hsa00190,hsa04714" Oxidative phosphorylation|Thermogenesis ATP5MG 3125.667611 2712.358992 3538.97623 1.304759525 0.383783934 0.105345927 1 129.1290047 165.6629758 10632 ATP synthase membrane subunit g "GO:0000276,GO:0005515,GO:0005739,GO:0005743,GO:0005753,GO:0006754,GO:0015986,GO:0042407,GO:0042776,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|ATP synthesis coupled proton transport|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714" Oxidative phosphorylation|Thermogenesis ATP5MGL 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.069493087 0.189374615 267020 ATP synthase membrane subunit g like "GO:0000276,GO:0005739,GO:0015078,GO:0015986" "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|mitochondrion|proton transmembrane transporter activity|ATP synthesis coupled proton transport" ATP5MJ 855.6868117 751.1788233 960.1948 1.278250625 0.354170731 0.156113287 1 45.34958506 56.99811718 9556 ATP synthase membrane subunit j "GO:0003674,GO:0005575,GO:0005753,GO:0008150,GO:0016021" molecular_function|cellular_component|mitochondrial proton-transporting ATP synthase complex|biological_process|integral component of membrane ATP5MK 2455.587694 2001.75631 2909.419079 1.4534332 0.539464766 0.022682113 0.831576143 124.8014664 178.3552686 84833 ATP synthase membrane subunit k "GO:0005739,GO:0005753,GO:0016021" mitochondrion|mitochondrial proton-transporting ATP synthase complex|integral component of membrane ATP5PB 2595.740399 2438.730141 2752.750658 1.128763946 0.174743813 0.460220775 1 49.52456066 54.96610199 515 ATP synthase peripheral stalk-membrane subunit b "GO:0000276,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005743,GO:0005753,GO:0005759,GO:0006754,GO:0015986,GO:0016020,GO:0021762,GO:0042407,GO:0042776,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|mitochondrial matrix|ATP biosynthetic process|ATP synthesis coupled proton transport|membrane|substantia nigra development|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5PD 2904.59168 2737.328925 3071.854435 1.122208737 0.16634105 0.482467767 1 239.8788403 264.6895311 10476 ATP synthase peripheral stalk subunit d "GO:0000274,GO:0005515,GO:0005739,GO:0005743,GO:0005753,GO:0006754,GO:0015986,GO:0042407,GO:0042776,GO:0044877,GO:0046933,GO:1901653" "mitochondrial proton-transporting ATP synthase, stator stalk|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|ATP synthesis coupled proton transport|cristae formation|mitochondrial ATP synthesis coupled proton transport|protein-containing complex binding|proton-transporting ATP synthase activity, rotational mechanism|cellular response to peptide" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5PF 1153.188503 890.5942835 1415.782723 1.589705604 0.668759619 0.006017608 0.464919713 31.66514328 49.49591318 522 ATP synthase peripheral stalk subunit F6 "GO:0000276,GO:0005515,GO:0005739,GO:0005743,GO:0005753,GO:0006754,GO:0021762,GO:0042407,GO:0042776,GO:0046933" "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|substantia nigra development|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase activity, rotational mechanism" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP5PO 1980.356439 1851.936711 2108.776167 1.138686951 0.187371175 0.428972193 1 130.7334108 146.3733843 539 ATP synthase peripheral stalk subunit OSCP "GO:0000274,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005753,GO:0005886,GO:0006754,GO:0015986,GO:0042407,GO:0042776,GO:0045261,GO:0046933,GO:1902600" "mitochondrial proton-transporting ATP synthase, stator stalk|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|plasma membrane|ATP biosynthetic process|ATP synthesis coupled proton transport|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase complex, catalytic core F(1)|proton-transporting ATP synthase activity, rotational mechanism|proton transmembrane transport" "hsa00190,hsa04714,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases ATP6AP1 2951.359386 3056.735987 2845.982786 0.931052861 -0.103065015 0.663979242 1 74.15108254 67.88331044 537 ATPase H+ transporting accessory protein 1 "GO:0005515,GO:0005524,GO:0005789,GO:0006879,GO:0008286,GO:0010008,GO:0016021,GO:0016469,GO:0030641,GO:0031267,GO:0033116,GO:0033180,GO:0033181,GO:0033572,GO:0034220,GO:0036295,GO:0045669,GO:0045780,GO:0045851,GO:0045921,GO:0051656,GO:0070062,GO:0070374,GO:1902600,GO:2001206" "protein binding|ATP binding|endoplasmic reticulum membrane|cellular iron ion homeostasis|insulin receptor signaling pathway|endosome membrane|integral component of membrane|proton-transporting two-sector ATPase complex|regulation of cellular pH|small GTPase binding|endoplasmic reticulum-Golgi intermediate compartment membrane|proton-transporting V-type ATPase, V1 domain|plasma membrane proton-transporting V-type ATPase complex|transferrin transport|ion transmembrane transport|cellular response to increased oxygen levels|positive regulation of osteoblast differentiation|positive regulation of bone resorption|pH reduction|positive regulation of exocytosis|establishment of organelle localization|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|proton transmembrane transport|positive regulation of osteoclast development" "hsa00190,hsa04142,hsa04145,hsa05110,hsa05120,hsa05152,hsa05161,hsa05165,hsa05323" Oxidative phosphorylation|Lysosome|Phagosome|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Hepatitis B|Human papillomavirus infection|Rheumatoid arthritis ATP6AP1L 93.11262646 97.79890497 88.42634795 0.904165011 -0.145342006 0.780327796 1 0.777151252 0.69091469 92270 ATPase H+ transporting accessory protein 1 like "GO:0016021,GO:0030641,GO:0033180,GO:0033181,GO:1902600" "integral component of membrane|regulation of cellular pH|proton-transporting V-type ATPase, V1 domain|plasma membrane proton-transporting V-type ATPase complex|proton transmembrane transport" ATP6AP2 4418.031958 4178.302153 4657.761763 1.114749866 0.156720026 0.51204698 1 99.45954795 109.0172163 10159 ATPase H+ transporting accessory protein 2 "GO:0000421,GO:0002003,GO:0005515,GO:0005764,GO:0005765,GO:0005789,GO:0005886,GO:0007042,GO:0009897,GO:0010008,GO:0016021,GO:0016324,GO:0016471,GO:0021626,GO:0021903,GO:0030177,GO:0030424,GO:0032591,GO:0032914,GO:0038023,GO:0043312,GO:0043408,GO:0044297,GO:0045211,GO:0048069,GO:0060323,GO:0070062,GO:0070821,GO:0090263,GO:0101003" autophagosome membrane|angiotensin maturation|protein binding|lysosome|lysosomal membrane|endoplasmic reticulum membrane|plasma membrane|lysosomal lumen acidification|external side of plasma membrane|endosome membrane|integral component of membrane|apical plasma membrane|vacuolar proton-transporting V-type ATPase complex|central nervous system maturation|rostrocaudal neural tube patterning|positive regulation of Wnt signaling pathway|axon|dendritic spine membrane|positive regulation of transforming growth factor beta1 production|signaling receptor activity|neutrophil degranulation|regulation of MAPK cascade|cell body|postsynaptic membrane|eye pigmentation|head morphogenesis|extracellular exosome|tertiary granule membrane|positive regulation of canonical Wnt signaling pathway|ficolin-1-rich granule membrane hsa04614 Renin-angiotensin system ATP6V0A1 734.7346466 767.8254454 701.6438479 0.913806454 -0.130039462 0.612197549 1 8.998118757 8.084945943 535 ATPase H+ transporting V0 subunit a1 "GO:0000220,GO:0005515,GO:0005765,GO:0005794,GO:0005829,GO:0005886,GO:0007035,GO:0008286,GO:0010008,GO:0016021,GO:0016241,GO:0016471,GO:0016607,GO:0030667,GO:0030670,GO:0033572,GO:0034220,GO:0042470,GO:0043231,GO:0043312,GO:0046961,GO:0048471,GO:0051117,GO:0070062,GO:0090383,GO:0101003,GO:1901998,GO:1902600" "vacuolar proton-transporting V-type ATPase, V0 domain|protein binding|lysosomal membrane|Golgi apparatus|cytosol|plasma membrane|vacuolar acidification|insulin receptor signaling pathway|endosome membrane|integral component of membrane|regulation of macroautophagy|vacuolar proton-transporting V-type ATPase complex|nuclear speck|secretory granule membrane|phagocytic vesicle membrane|transferrin transport|ion transmembrane transport|melanosome|intracellular membrane-bounded organelle|neutrophil degranulation|proton-transporting ATPase activity, rotational mechanism|perinuclear region of cytoplasm|ATPase binding|extracellular exosome|phagosome acidification|ficolin-1-rich granule membrane|toxin transport|proton transmembrane transport" "hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323" Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis ATP6V0A2 298.5163391 304.8412676 292.1914106 0.958503463 -0.061144451 0.856222542 1 5.163065115 4.866004062 23545 ATPase H+ transporting V0 subunit a2 "GO:0000220,GO:0001669,GO:0005515,GO:0005765,GO:0005886,GO:0006879,GO:0006955,GO:0007035,GO:0008286,GO:0010008,GO:0016021,GO:0016241,GO:0016471,GO:0030670,GO:0033572,GO:0034220,GO:0036295,GO:0046961,GO:0048471,GO:0051117,GO:0090383,GO:1902600" "vacuolar proton-transporting V-type ATPase, V0 domain|acrosomal vesicle|protein binding|lysosomal membrane|plasma membrane|cellular iron ion homeostasis|immune response|vacuolar acidification|insulin receptor signaling pathway|endosome membrane|integral component of membrane|regulation of macroautophagy|vacuolar proton-transporting V-type ATPase complex|phagocytic vesicle membrane|transferrin transport|ion transmembrane transport|cellular response to increased oxygen levels|proton-transporting ATPase activity, rotational mechanism|perinuclear region of cytoplasm|ATPase binding|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323" Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis ATP6V0A4 69.01956089 58.26317743 79.77594435 1.369234358 0.453369399 0.402748039 1 0.888145872 1.195730393 50617 ATPase H+ transporting V0 subunit a4 "GO:0000220,GO:0001503,GO:0005515,GO:0005765,GO:0005768,GO:0005886,GO:0006885,GO:0007035,GO:0007588,GO:0007605,GO:0008286,GO:0010008,GO:0016021,GO:0016324,GO:0016471,GO:0030670,GO:0031526,GO:0033572,GO:0034220,GO:0045177,GO:0046961,GO:0051117,GO:0070062,GO:0090383,GO:1902600" "vacuolar proton-transporting V-type ATPase, V0 domain|ossification|protein binding|lysosomal membrane|endosome|plasma membrane|regulation of pH|vacuolar acidification|excretion|sensory perception of sound|insulin receptor signaling pathway|endosome membrane|integral component of membrane|apical plasma membrane|vacuolar proton-transporting V-type ATPase complex|phagocytic vesicle membrane|brush border membrane|transferrin transport|ion transmembrane transport|apical part of cell|proton-transporting ATPase activity, rotational mechanism|ATPase binding|extracellular exosome|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323" Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis ATP6V0B 1429.834801 1403.518328 1456.151273 1.037500718 0.053112335 0.826883212 1 75.88976048 77.41814603 533 ATPase H+ transporting V0 subunit b "GO:0005215,GO:0005515,GO:0005774,GO:0008286,GO:0010008,GO:0016021,GO:0016241,GO:0030670,GO:0033179,GO:0033572,GO:0034220,GO:0046961,GO:0090383,GO:1902600" "transporter activity|protein binding|vacuolar membrane|insulin receptor signaling pathway|endosome membrane|integral component of membrane|regulation of macroautophagy|phagocytic vesicle membrane|proton-transporting V-type ATPase, V0 domain|transferrin transport|ion transmembrane transport|proton-transporting ATPase activity, rotational mechanism|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04142,hsa04145,hsa04721,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323" Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis ATP6V0C 1837.868813 1643.853935 2031.883691 1.236048805 0.305735708 0.19708115 1 76.68659372 93.20221746 527 ATPase H+ transporting V0 subunit c "GO:0005515,GO:0005765,GO:0005886,GO:0005925,GO:0008286,GO:0010008,GO:0015986,GO:0016021,GO:0016032,GO:0016241,GO:0030177,GO:0030670,GO:0031625,GO:0033179,GO:0033572,GO:0034220,GO:0035577,GO:0043312,GO:0046933,GO:0046961,GO:0070062,GO:0070821,GO:0090383,GO:0101003,GO:1902600" "protein binding|lysosomal membrane|plasma membrane|focal adhesion|insulin receptor signaling pathway|endosome membrane|ATP synthesis coupled proton transport|integral component of membrane|viral process|regulation of macroautophagy|positive regulation of Wnt signaling pathway|phagocytic vesicle membrane|ubiquitin protein ligase binding|proton-transporting V-type ATPase, V0 domain|transferrin transport|ion transmembrane transport|azurophil granule membrane|neutrophil degranulation|proton-transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism|extracellular exosome|tertiary granule membrane|phagosome acidification|ficolin-1-rich granule membrane|proton transmembrane transport" "hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323" Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis ATP6V0D1 1668.343673 1646.975176 1689.712171 1.025948779 0.036958705 0.878823329 1 44.25782384 44.64644804 9114 ATPase H+ transporting V0 subunit d1 "GO:0005515,GO:0005765,GO:0005769,GO:0005813,GO:0006879,GO:0007034,GO:0007035,GO:0008286,GO:0010008,GO:0016020,GO:0016241,GO:0016471,GO:0030670,GO:0033179,GO:0033181,GO:0033572,GO:0034220,GO:0036295,GO:0036498,GO:0046961,GO:0060271,GO:0070062,GO:0090383,GO:1902600" "protein binding|lysosomal membrane|early endosome|centrosome|cellular iron ion homeostasis|vacuolar transport|vacuolar acidification|insulin receptor signaling pathway|endosome membrane|membrane|regulation of macroautophagy|vacuolar proton-transporting V-type ATPase complex|phagocytic vesicle membrane|proton-transporting V-type ATPase, V0 domain|plasma membrane proton-transporting V-type ATPase complex|transferrin transport|ion transmembrane transport|cellular response to increased oxygen levels|IRE1-mediated unfolded protein response|proton-transporting ATPase activity, rotational mechanism|cilium assembly|extracellular exosome|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05203,hsa05323" Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Viral carcinogenesis|Rheumatoid arthritis ATP6V0D2 3.641448589 7.282897178 0 0 #NAME? 0.060320757 1 0.163997822 0 245972 ATPase H+ transporting V0 subunit d2 "GO:0005515,GO:0005765,GO:0005769,GO:0007034,GO:0007035,GO:0008286,GO:0010008,GO:0016020,GO:0016241,GO:0016324,GO:0016471,GO:0030670,GO:0033179,GO:0033181,GO:0033572,GO:0034220,GO:0046961,GO:0070062,GO:0090383,GO:1902600" "protein binding|lysosomal membrane|early endosome|vacuolar transport|vacuolar acidification|insulin receptor signaling pathway|endosome membrane|membrane|regulation of macroautophagy|apical plasma membrane|vacuolar proton-transporting V-type ATPase complex|phagocytic vesicle membrane|proton-transporting V-type ATPase, V0 domain|plasma membrane proton-transporting V-type ATPase complex|transferrin transport|ion transmembrane transport|proton-transporting ATPase activity, rotational mechanism|extracellular exosome|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05203,hsa05323" Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Viral carcinogenesis|Rheumatoid arthritis ATP6V0E1 2471.65313 2284.748886 2658.557374 1.163610316 0.218607992 0.355265719 1 85.92871661 98.31438503 8992 ATPase H+ transporting V0 subunit e1 "GO:0005515,GO:0007035,GO:0008286,GO:0010008,GO:0016021,GO:0016241,GO:0016787,GO:0030670,GO:0033179,GO:0033572,GO:0034220,GO:0042625,GO:0046961,GO:0055085,GO:0090383,GO:1902600" "protein binding|vacuolar acidification|insulin receptor signaling pathway|endosome membrane|integral component of membrane|regulation of macroautophagy|hydrolase activity|phagocytic vesicle membrane|proton-transporting V-type ATPase, V0 domain|transferrin transport|ion transmembrane transport|ATPase-coupled ion transmembrane transporter activity|proton-transporting ATPase activity, rotational mechanism|transmembrane transport|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V0E2 796.9575331 698.1177153 895.797351 1.283160893 0.359702079 0.153135136 1 12.20349144 15.3970101 155066 ATPase H+ transporting V0 subunit e2 "GO:0007035,GO:0008286,GO:0010008,GO:0016021,GO:0016241,GO:0016787,GO:0030670,GO:0033179,GO:0033572,GO:0034220,GO:0042625,GO:0046961,GO:0055085,GO:0090383,GO:1902600" "vacuolar acidification|insulin receptor signaling pathway|endosome membrane|integral component of membrane|regulation of macroautophagy|hydrolase activity|phagocytic vesicle membrane|proton-transporting V-type ATPase, V0 domain|transferrin transport|ion transmembrane transport|ATPase-coupled ion transmembrane transporter activity|proton-transporting ATPase activity, rotational mechanism|transmembrane transport|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1A 1470.123478 1502.357647 1437.88931 0.957088556 -0.063275677 0.793419499 1 17.52526041 16.49254895 523 ATPase H+ transporting V1 subunit A "GO:0005524,GO:0005654,GO:0005765,GO:0005774,GO:0005829,GO:0005886,GO:0005902,GO:0006879,GO:0008286,GO:0015986,GO:0016241,GO:0016324,GO:0016469,GO:0033180,GO:0033572,GO:0034220,GO:0036295,GO:0043231,GO:0046933,GO:0046961,GO:0070062,GO:0090383" "ATP binding|nucleoplasm|lysosomal membrane|vacuolar membrane|cytosol|plasma membrane|microvillus|cellular iron ion homeostasis|insulin receptor signaling pathway|ATP synthesis coupled proton transport|regulation of macroautophagy|apical plasma membrane|proton-transporting two-sector ATPase complex|proton-transporting V-type ATPase, V1 domain|transferrin transport|ion transmembrane transport|cellular response to increased oxygen levels|intracellular membrane-bounded organelle|proton-transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism|extracellular exosome|phagosome acidification" "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1B1 12.00941903 12.48496659 11.53387147 0.923820772 -0.11431511 1 1 0.279957866 0.254303054 525 ATPase H+ transporting V1 subunit B1 "GO:0001503,GO:0003091,GO:0003096,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005902,GO:0006693,GO:0006885,GO:0007588,GO:0007605,GO:0008286,GO:0010468,GO:0015078,GO:0016241,GO:0016323,GO:0016324,GO:0016328,GO:0016471,GO:0016787,GO:0030534,GO:0033180,GO:0033572,GO:0034220,GO:0035812,GO:0042048,GO:0042472,GO:0044877,GO:0045851,GO:0046034,GO:0055064,GO:0055074,GO:0055075,GO:0070062,GO:0090383,GO:0098850,GO:1902600" "ossification|renal water homeostasis|renal sodium ion transport|protein binding|ATP binding|cytoplasm|cytosol|microvillus|prostaglandin metabolic process|regulation of pH|excretion|sensory perception of sound|insulin receptor signaling pathway|regulation of gene expression|proton transmembrane transporter activity|regulation of macroautophagy|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|vacuolar proton-transporting V-type ATPase complex|hydrolase activity|adult behavior|proton-transporting V-type ATPase, V1 domain|transferrin transport|ion transmembrane transport|renal sodium excretion|olfactory behavior|inner ear morphogenesis|protein-containing complex binding|pH reduction|ATP metabolic process|chloride ion homeostasis|calcium ion homeostasis|potassium ion homeostasis|extracellular exosome|phagosome acidification|extrinsic component of synaptic vesicle membrane|proton transmembrane transport" "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1B2 1781.729279 1822.805122 1740.653436 0.954931174 -0.066531339 0.780911594 1 34.06154034 31.98214102 526 ATPase H+ transporting V1 subunit B2 "GO:0001726,GO:0005515,GO:0005524,GO:0005765,GO:0005829,GO:0005886,GO:0005902,GO:0008286,GO:0012505,GO:0015078,GO:0016021,GO:0016241,GO:0016324,GO:0016787,GO:0033180,GO:0033572,GO:0034220,GO:0042470,GO:0043231,GO:0046034,GO:0046961,GO:0070062,GO:0090383,GO:1902600" "ruffle|protein binding|ATP binding|lysosomal membrane|cytosol|plasma membrane|microvillus|insulin receptor signaling pathway|endomembrane system|proton transmembrane transporter activity|integral component of membrane|regulation of macroautophagy|apical plasma membrane|hydrolase activity|proton-transporting V-type ATPase, V1 domain|transferrin transport|ion transmembrane transport|melanosome|intracellular membrane-bounded organelle|ATP metabolic process|proton-transporting ATPase activity, rotational mechanism|extracellular exosome|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1C1 2746.852663 2810.157897 2683.547429 0.954945426 -0.066509808 0.779698164 1 26.61454518 24.99014524 528 ATPase H+ transporting V1 subunit C1 "GO:0000221,GO:0005215,GO:0005515,GO:0005765,GO:0005829,GO:0005886,GO:0008286,GO:0016241,GO:0016469,GO:0031410,GO:0033572,GO:0034220,GO:0045177,GO:0046961,GO:0070062,GO:0090383,GO:1902600" "vacuolar proton-transporting V-type ATPase, V1 domain|transporter activity|protein binding|lysosomal membrane|cytosol|plasma membrane|insulin receptor signaling pathway|regulation of macroautophagy|proton-transporting two-sector ATPase complex|cytoplasmic vesicle|transferrin transport|ion transmembrane transport|apical part of cell|proton-transporting ATPase activity, rotational mechanism|extracellular exosome|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1D 2318.127302 2039.21121 2597.043393 1.273552921 0.34885891 0.140064372 1 68.06063437 85.22836705 51382 ATPase H+ transporting V1 subunit D "GO:0005515,GO:0005765,GO:0005813,GO:0005829,GO:0005886,GO:0005929,GO:0008286,GO:0016020,GO:0016241,GO:0033176,GO:0033572,GO:0034220,GO:0035579,GO:0043312,GO:0046961,GO:0060271,GO:0061512,GO:0070062,GO:0090383,GO:1902600" "protein binding|lysosomal membrane|centrosome|cytosol|plasma membrane|cilium|insulin receptor signaling pathway|membrane|regulation of macroautophagy|proton-transporting V-type ATPase complex|transferrin transport|ion transmembrane transport|specific granule membrane|neutrophil degranulation|proton-transporting ATPase activity, rotational mechanism|cilium assembly|protein localization to cilium|extracellular exosome|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1E1 2825.481825 2376.305308 3274.658342 1.378046134 0.462624187 0.050740212 1 95.13806963 128.9107903 529 ATPase H+ transporting V1 subunit E1 "GO:0005515,GO:0005765,GO:0005768,GO:0005829,GO:0005902,GO:0008286,GO:0008553,GO:0016241,GO:0016324,GO:0016469,GO:0016787,GO:0033178,GO:0033572,GO:0034220,GO:0046961,GO:0051117,GO:0070062,GO:0090383,GO:1902600" "protein binding|lysosomal membrane|endosome|cytosol|microvillus|insulin receptor signaling pathway|proton-exporting ATPase activity, phosphorylative mechanism|regulation of macroautophagy|apical plasma membrane|proton-transporting two-sector ATPase complex|hydrolase activity|proton-transporting two-sector ATPase complex, catalytic domain|transferrin transport|ion transmembrane transport|proton-transporting ATPase activity, rotational mechanism|ATPase binding|extracellular exosome|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1E2 70.29271813 79.07145508 61.51398118 0.777954334 -0.362242623 0.504544917 1 1.332880048 1.019568361 90423 ATPase H+ transporting V1 subunit E2 "GO:0001669,GO:0005515,GO:0005829,GO:0008286,GO:0008553,GO:0016241,GO:0033178,GO:0033572,GO:0034220,GO:0046961,GO:0090383,GO:1902600" "acrosomal vesicle|protein binding|cytosol|insulin receptor signaling pathway|proton-exporting ATPase activity, phosphorylative mechanism|regulation of macroautophagy|proton-transporting two-sector ATPase complex, catalytic domain|transferrin transport|ion transmembrane transport|proton-transporting ATPase activity, rotational mechanism|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1F 1415.284097 1336.931839 1493.636356 1.117212046 0.159903034 0.505168815 1 93.63463921 102.8592444 9296 ATPase H+ transporting V1 subunit F "GO:0005515,GO:0005829,GO:0008286,GO:0015078,GO:0016020,GO:0016469,GO:0016471,GO:0016887,GO:0033180,GO:0033572,GO:0034220,GO:0042625,GO:0046961,GO:0070062,GO:0090383,GO:1902600" "protein binding|cytosol|insulin receptor signaling pathway|proton transmembrane transporter activity|membrane|proton-transporting two-sector ATPase complex|vacuolar proton-transporting V-type ATPase complex|ATPase activity|proton-transporting V-type ATPase, V1 domain|transferrin transport|ion transmembrane transport|ATPase-coupled ion transmembrane transporter activity|proton-transporting ATPase activity, rotational mechanism|extracellular exosome|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1G1 1347.309981 1268.264523 1426.355439 1.124651374 0.169477856 0.481241098 1 43.30450839 47.88750492 9550 ATPase H+ transporting V1 subunit G1 "GO:0005515,GO:0005765,GO:0005829,GO:0005886,GO:0006879,GO:0008286,GO:0016241,GO:0016471,GO:0016887,GO:0033572,GO:0034220,GO:0036295,GO:0046961,GO:0051117,GO:0070062,GO:0090383,GO:1902600" "protein binding|lysosomal membrane|cytosol|plasma membrane|cellular iron ion homeostasis|insulin receptor signaling pathway|regulation of macroautophagy|vacuolar proton-transporting V-type ATPase complex|ATPase activity|transferrin transport|ion transmembrane transport|cellular response to increased oxygen levels|proton-transporting ATPase activity, rotational mechanism|ATPase binding|extracellular exosome|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1G2 17.57317953 19.76786377 15.3784953 0.777954334 -0.362242623 0.732472871 1 0.712339337 0.544894232 534 ATPase H+ transporting V1 subunit G2 "GO:0005515,GO:0005829,GO:0008286,GO:0016241,GO:0016471,GO:0033572,GO:0034220,GO:0042470,GO:0042626,GO:0090383,GO:1902600" protein binding|cytosol|insulin receptor signaling pathway|regulation of macroautophagy|vacuolar proton-transporting V-type ATPase complex|transferrin transport|ion transmembrane transport|melanosome|ATPase-coupled transmembrane transporter activity|phagosome acidification|proton transmembrane transport "hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323" Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1H 1982.744852 1788.471464 2177.01824 1.217250755 0.283626396 0.230818912 1 40.71989547 48.73689821 51606 ATPase H+ transporting V1 subunit H "GO:0000221,GO:0005515,GO:0005765,GO:0005829,GO:0005886,GO:0006897,GO:0007035,GO:0008286,GO:0016241,GO:0016887,GO:0030234,GO:0033572,GO:0034220,GO:0046961,GO:0050690,GO:0050790,GO:0070062,GO:0090383,GO:1902600" "vacuolar proton-transporting V-type ATPase, V1 domain|protein binding|lysosomal membrane|cytosol|plasma membrane|endocytosis|vacuolar acidification|insulin receptor signaling pathway|regulation of macroautophagy|ATPase activity|enzyme regulator activity|transferrin transport|ion transmembrane transport|proton-transporting ATPase activity, rotational mechanism|regulation of defense response to virus by virus|regulation of catalytic activity|extracellular exosome|phagosome acidification|proton transmembrane transport" "hsa00190,hsa04142,hsa04145,hsa04150,hsa04721,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323" Oxidative phosphorylation|Lysosome|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis ATP7A 585.6818603 652.3395044 519.0242162 0.795635114 -0.329821146 0.211977687 1 4.099642063 3.207237055 538 ATPase copper transporting alpha "GO:0001568,GO:0001701,GO:0001889,GO:0001974,GO:0002082,GO:0005375,GO:0005507,GO:0005515,GO:0005524,GO:0005634,GO:0005770,GO:0005783,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0005902,GO:0006568,GO:0006584,GO:0006825,GO:0006878,GO:0007005,GO:0007565,GO:0007595,GO:0007626,GO:0010041,GO:0010042,GO:0010043,GO:0010273,GO:0010468,GO:0010592,GO:0015677,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0016532,GO:0018205,GO:0019430,GO:0019730,GO:0021702,GO:0021860,GO:0021954,GO:0030140,GO:0030141,GO:0030198,GO:0030199,GO:0030670,GO:0031069,GO:0031252,GO:0031526,GO:0032767,GO:0034220,GO:0034760,GO:0036120,GO:0042093,GO:0042414,GO:0042415,GO:0042417,GO:0042428,GO:0043005,GO:0043025,GO:0043085,GO:0043204,GO:0043473,GO:0043588,GO:0043682,GO:0045121,GO:0045793,GO:0048251,GO:0048286,GO:0048471,GO:0048812,GO:0050679,GO:0051087,GO:0051216,GO:0051353,GO:0051542,GO:0060003,GO:0071230,GO:0071236,GO:0071276,GO:0071279,GO:0071280,GO:0071281,GO:0071284,GO:0071456,GO:0072511,GO:1903036,GO:1903136,GO:1904754,GO:1904959" "blood vessel development|in utero embryonic development|liver development|blood vessel remodeling|regulation of oxidative phosphorylation|copper ion transmembrane transporter activity|copper ion binding|protein binding|ATP binding|nucleus|late endosome|endoplasmic reticulum|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|microvillus|tryptophan metabolic process|catecholamine metabolic process|copper ion transport|cellular copper ion homeostasis|mitochondrion organization|female pregnancy|lactation|locomotory behavior|response to iron(III) ion|response to manganese ion|response to zinc ion|detoxification of copper ion|regulation of gene expression|positive regulation of lamellipodium assembly|copper ion import|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|superoxide dismutase copper chaperone activity|peptidyl-lysine modification|removal of superoxide radicals|antimicrobial humoral response|cerebellar Purkinje cell differentiation|pyramidal neuron development|central nervous system neuron development|trans-Golgi network transport vesicle|secretory granule|extracellular matrix organization|collagen fibril organization|phagocytic vesicle membrane|hair follicle morphogenesis|cell leading edge|brush border membrane|copper-dependent protein binding|ion transmembrane transport|negative regulation of iron ion transmembrane transport|cellular response to platelet-derived growth factor stimulus|T-helper cell differentiation|epinephrine metabolic process|norepinephrine metabolic process|dopamine metabolic process|serotonin metabolic process|neuron projection|neuronal cell body|positive regulation of catalytic activity|perikaryon|pigmentation|skin development|copper transmembrane transporter activity, phosphorylative mechanism|membrane raft|positive regulation of cell size|elastic fiber assembly|lung alveolus development|perinuclear region of cytoplasm|neuron projection morphogenesis|positive regulation of epithelial cell proliferation|chaperone binding|cartilage development|positive regulation of oxidoreductase activity|elastin biosynthetic process|copper ion export|cellular response to amino acid stimulus|cellular response to antibiotic|cellular response to cadmium ion|cellular response to cobalt ion|cellular response to copper ion|cellular response to iron ion|cellular response to lead ion|cellular response to hypoxia|divalent inorganic cation transport|positive regulation of response to wounding|cuprous ion binding|positive regulation of vascular associated smooth muscle cell migration|regulation of cytochrome-c oxidase activity" "hsa01524,hsa04978" Platinum drug resistance|Mineral absorption ATP7B 397.0643927 330.8516147 463.2771708 1.400256641 0.485691271 0.093755428 1 1.42085319 1.956266539 540 ATPase copper transporting beta "GO:0000139,GO:0005375,GO:0005507,GO:0005515,GO:0005524,GO:0005739,GO:0005770,GO:0005794,GO:0005802,GO:0005887,GO:0006825,GO:0006878,GO:0015677,GO:0016020,GO:0016323,GO:0031410,GO:0032588,GO:0034220,GO:0043682,GO:0046688,GO:0048471,GO:0051208,GO:0060003,GO:0072511" "Golgi membrane|copper ion transmembrane transporter activity|copper ion binding|protein binding|ATP binding|mitochondrion|late endosome|Golgi apparatus|trans-Golgi network|integral component of plasma membrane|copper ion transport|cellular copper ion homeostasis|copper ion import|membrane|basolateral plasma membrane|cytoplasmic vesicle|trans-Golgi network membrane|ion transmembrane transport|copper transmembrane transporter activity, phosphorylative mechanism|response to copper ion|perinuclear region of cytoplasm|sequestering of calcium ion|copper ion export|divalent inorganic cation transport" "hsa01524,hsa04978" Platinum drug resistance|Mineral absorption ATP8A1 190.7435691 213.2848459 168.2022923 0.788627488 -0.342584098 0.357201792 1 1.364986237 1.058452472 10396 ATPase phospholipid transporting 8A1 "GO:0000287,GO:0005515,GO:0005524,GO:0005783,GO:0005794,GO:0005802,GO:0005886,GO:0006869,GO:0007612,GO:0016020,GO:0016021,GO:0016887,GO:0019829,GO:0022857,GO:0030335,GO:0031090,GO:0031410,GO:0034220,GO:0035577,GO:0035579,GO:0042584,GO:0043231,GO:0043312,GO:0045332,GO:0055085,GO:0061092,GO:0070062,GO:0098655,GO:0140326,GO:0140327,GO:0140331,GO:0140346,GO:0150104,GO:1990531" magnesium ion binding|protein binding|ATP binding|endoplasmic reticulum|Golgi apparatus|trans-Golgi network|plasma membrane|lipid transport|learning|membrane|integral component of membrane|ATPase activity|ATPase-coupled cation transmembrane transporter activity|transmembrane transporter activity|positive regulation of cell migration|organelle membrane|cytoplasmic vesicle|ion transmembrane transport|azurophil granule membrane|specific granule membrane|chromaffin granule membrane|intracellular membrane-bounded organelle|neutrophil degranulation|phospholipid translocation|transmembrane transport|positive regulation of phospholipid translocation|extracellular exosome|cation transmembrane transport|ATPase-coupled intramembrane lipid transporter activity|flippase activity|aminophospholipid translocation|phosphatidylserine flippase activity|transport across blood-brain barrier|phospholipid-translocating ATPase complex ATP8A2 77.54101677 80.11186896 74.97016457 0.935818444 -0.095699432 0.876107419 1 0.22257396 0.204803386 51761 ATPase phospholipid transporting 8A2 "GO:0000287,GO:0001750,GO:0003011,GO:0005515,GO:0005524,GO:0005654,GO:0005768,GO:0005794,GO:0005886,GO:0007409,GO:0007568,GO:0008285,GO:0010842,GO:0010976,GO:0010996,GO:0016021,GO:0016887,GO:0040018,GO:0042472,GO:0042755,GO:0043588,GO:0045332,GO:0048666,GO:0050884,GO:0050908,GO:0060052,GO:0061092,GO:0090555,GO:0140326,GO:0140331,GO:0140346" magnesium ion binding|photoreceptor outer segment|involuntary skeletal muscle contraction|protein binding|ATP binding|nucleoplasm|endosome|Golgi apparatus|plasma membrane|axonogenesis|aging|negative regulation of cell population proliferation|retina layer formation|positive regulation of neuron projection development|response to auditory stimulus|integral component of membrane|ATPase activity|positive regulation of multicellular organism growth|inner ear morphogenesis|eating behavior|skin development|phospholipid translocation|neuron development|neuromuscular process controlling posture|detection of light stimulus involved in visual perception|neurofilament cytoskeleton organization|positive regulation of phospholipid translocation|phosphatidylethanolamine flippase activity|ATPase-coupled intramembrane lipid transporter activity|aminophospholipid translocation|phosphatidylserine flippase activity ATP8B1 1988.579142 2118.282665 1858.875619 0.877538985 -0.188464877 0.426183524 1 18.34910771 15.83261122 5205 ATPase phospholipid transporting 8B1 "GO:0000287,GO:0005515,GO:0005524,GO:0005654,GO:0005783,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0005887,GO:0006855,GO:0007030,GO:0007605,GO:0008206,GO:0015721,GO:0016324,GO:0016604,GO:0021650,GO:0031526,GO:0032420,GO:0032534,GO:0034220,GO:0045176,GO:0045332,GO:0045892,GO:0060119,GO:0140326,GO:0140331,GO:0140345,GO:0140346,GO:1901612,GO:1903729,GO:1990531,GO:2001225" "magnesium ion binding|protein binding|ATP binding|nucleoplasm|endoplasmic reticulum|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|integral component of plasma membrane|drug transmembrane transport|Golgi organization|sensory perception of sound|bile acid metabolic process|bile acid and bile salt transport|apical plasma membrane|nuclear body|vestibulocochlear nerve formation|brush border membrane|stereocilium|regulation of microvillus assembly|ion transmembrane transport|apical protein localization|phospholipid translocation|negative regulation of transcription, DNA-templated|inner ear receptor cell development|ATPase-coupled intramembrane lipid transporter activity|aminophospholipid translocation|phosphatidylcholine flippase activity|phosphatidylserine flippase activity|cardiolipin binding|regulation of plasma membrane organization|phospholipid-translocating ATPase complex|regulation of chloride transport" ATP8B2 1480.120652 1638.651865 1321.589439 0.806510198 -0.31023532 0.193877562 1 13.69001852 10.85638103 57198 ATPase phospholipid transporting 8B2 "GO:0000287,GO:0005524,GO:0005789,GO:0005794,GO:0005802,GO:0005886,GO:0005887,GO:0007030,GO:0034220,GO:0045332,GO:0140326,GO:0140345" magnesium ion binding|ATP binding|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|plasma membrane|integral component of plasma membrane|Golgi organization|ion transmembrane transport|phospholipid translocation|ATPase-coupled intramembrane lipid transporter activity|phosphatidylcholine flippase activity ATP8B3 130.9046796 131.0921492 130.71721 0.997139881 -0.004132192 1 1 1.301608757 1.276167636 148229 ATPase phospholipid transporting 8B3 "GO:0000287,GO:0002080,GO:0005524,GO:0005789,GO:0005802,GO:0005886,GO:0007030,GO:0007339,GO:0016021,GO:0045332,GO:0140326" magnesium ion binding|acrosomal membrane|ATP binding|endoplasmic reticulum membrane|trans-Golgi network|plasma membrane|Golgi organization|binding of sperm to zona pellucida|integral component of membrane|phospholipid translocation|ATPase-coupled intramembrane lipid transporter activity ATP9A 3986.884314 4151.251392 3822.517237 0.920810829 -0.119023294 0.617604078 1 27.68962093 25.07024668 10079 ATPase phospholipid transporting 9A (putative) "GO:0000287,GO:0002020,GO:0005524,GO:0005768,GO:0005769,GO:0005802,GO:0005886,GO:0006890,GO:0006897,GO:0016021,GO:0031901,GO:0045332,GO:0048471,GO:0055037,GO:0140326" "magnesium ion binding|protease binding|ATP binding|endosome|early endosome|trans-Golgi network|plasma membrane|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|endocytosis|integral component of membrane|early endosome membrane|phospholipid translocation|perinuclear region of cytoplasm|recycling endosome|ATPase-coupled intramembrane lipid transporter activity" ATP9B 279.5756532 299.6391982 259.5121081 0.866081974 -0.207424514 0.525335956 1 1.309894601 1.11549218 374868 ATPase phospholipid transporting 9B (putative) "GO:0000287,GO:0005524,GO:0005768,GO:0005802,GO:0005886,GO:0006890,GO:0006897,GO:0016021,GO:0045332,GO:0048471,GO:0140326" "magnesium ion binding|ATP binding|endosome|trans-Golgi network|plasma membrane|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|endocytosis|integral component of membrane|phospholipid translocation|perinuclear region of cytoplasm|ATPase-coupled intramembrane lipid transporter activity" ATPAF1 670.6101843 686.6731625 654.547206 0.953215069 -0.069126336 0.793567491 1 8.227769338 7.711594517 64756 ATP synthase mitochondrial F1 complex assembly factor 1 "GO:0005515,GO:0005739,GO:0033615" protein binding|mitochondrion|mitochondrial proton-transporting ATP synthase complex assembly ATPAF2 216.0506557 221.608157 210.4931544 0.949843892 -0.074237671 0.845653352 1 3.910985463 3.652663078 91647 ATP synthase mitochondrial F1 complex assembly factor 2 "GO:0005515,GO:0005739,GO:0005829,GO:0016607,GO:0043461" protein binding|mitochondrion|cytosol|nuclear speck|proton-transporting ATP synthase complex assembly ATPSCKMT 314.6427543 337.094098 292.1914106 0.866794798 -0.206237599 0.51004457 1 6.745441491 5.749073415 134145 ATP synthase c subunit lysine N-methyltransferase "GO:0005515,GO:0005739,GO:0016021,GO:0016279,GO:0018022,GO:0018023,GO:0030061,GO:1904058,GO:1905273,GO:1905706" "protein binding|mitochondrion|integral component of membrane|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation|peptidyl-lysine trimethylation|mitochondrial crista|positive regulation of sensory perception of pain|positive regulation of proton-transporting ATP synthase activity, rotational mechanism|regulation of mitochondrial ATP synthesis coupled proton transport" ATR 1134.864946 1242.254176 1027.475717 0.827105867 -0.273856093 0.260276944 1 8.126602378 6.609084292 545 ATR serine/threonine kinase "GO:0000077,GO:0000723,GO:0000781,GO:0003677,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005794,GO:0006260,GO:0006281,GO:0006974,GO:0007275,GO:0008156,GO:0016605,GO:0018105,GO:0031297,GO:0032212,GO:0032405,GO:0032407,GO:0034644,GO:0036297,GO:0042493,GO:0043517,GO:0046777,GO:0070198,GO:0071480,GO:0090399,GO:0097694,GO:0097695,GO:0106310,GO:0106311,GO:1900034,GO:1901796,GO:1904884" "DNA damage checkpoint|telomere maintenance|chromosome, telomeric region|DNA binding|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|chromosome|Golgi apparatus|DNA replication|DNA repair|cellular response to DNA damage stimulus|multicellular organism development|negative regulation of DNA replication|PML body|peptidyl-serine phosphorylation|replication fork processing|positive regulation of telomere maintenance via telomerase|MutLalpha complex binding|MutSalpha complex binding|cellular response to UV|interstrand cross-link repair|response to drug|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|protein localization to chromosome, telomeric region|cellular response to gamma radiation|replicative senescence|establishment of RNA localization to telomere|establishment of protein-containing complex localization to telomere|protein serine kinase activity|protein threonine kinase activity|regulation of cellular response to heat|regulation of signal transduction by p53 class mediator|positive regulation of telomerase catalytic core complex assembly" "hsa03460,hsa04110,hsa04115,hsa04218,hsa05165,hsa05166,hsa05170" Fanconi anemia pathway|Cell cycle|p53 signaling pathway|Cellular senescence|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection ATRAID 1299.836557 1308.840664 1290.832449 0.986241094 -0.019987727 0.937187386 1 50.14387704 48.62640724 51374 all-trans retinoic acid induced differentiation factor "GO:0003674,GO:0005515,GO:0005635,GO:0005765,GO:0005886,GO:0010468,GO:0016021,GO:0030154,GO:0030501,GO:0033689,GO:0045669,GO:0048471,GO:1903363" molecular_function|protein binding|nuclear envelope|lysosomal membrane|plasma membrane|regulation of gene expression|integral component of membrane|cell differentiation|positive regulation of bone mineralization|negative regulation of osteoblast proliferation|positive regulation of osteoblast differentiation|perinuclear region of cytoplasm|negative regulation of cellular protein catabolic process ATRIP 255.7996193 268.4267817 243.1724569 0.905917268 -0.142548791 0.675835123 1 3.007651479 2.679089525 84126 ATR interacting protein "GO:0000077,GO:0005515,GO:0005654,GO:0006260,GO:0006281,GO:0036297,GO:0070530,GO:1901796" DNA damage checkpoint|protein binding|nucleoplasm|DNA replication|DNA repair|interstrand cross-link repair|K63-linked polyubiquitin modification-dependent protein binding|regulation of signal transduction by p53 class mediator hsa03460 Fanconi anemia pathway ATRN 2170.801255 2309.718819 2031.883691 0.879710411 -0.18489941 0.434553511 1 13.85316344 11.98284297 8455 attractin "GO:0005604,GO:0005615,GO:0005737,GO:0005886,GO:0005887,GO:0006954,GO:0006979,GO:0009887,GO:0009888,GO:0016477,GO:0021549,GO:0030246,GO:0034446,GO:0038023,GO:0040014,GO:0042552,GO:0043473,GO:0070062" basement membrane|extracellular space|cytoplasm|plasma membrane|integral component of plasma membrane|inflammatory response|response to oxidative stress|animal organ morphogenesis|tissue development|cell migration|cerebellum development|carbohydrate binding|substrate adhesion-dependent cell spreading|signaling receptor activity|regulation of multicellular organism growth|myelination|pigmentation|extracellular exosome ATRNL1 209.9025216 173.7491184 246.0559247 1.416156393 0.501980598 0.159978881 1 0.373702136 0.520364878 26033 attractin like 1 "GO:0005604,GO:0007186,GO:0009887,GO:0009888,GO:0016021,GO:0016477,GO:0030246,GO:0034446" basement membrane|G protein-coupled receptor signaling pathway|animal organ morphogenesis|tissue development|integral component of membrane|cell migration|carbohydrate binding|substrate adhesion-dependent cell spreading ATRX 2992.090242 2952.694599 3031.485885 1.026684536 0.037992961 0.873801988 1 13.61381287 13.74320346 546 ATRX chromatin remodeler "GO:0000212,GO:0000228,GO:0000779,GO:0000781,GO:0000792,GO:0003677,GO:0003678,GO:0003682,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005721,GO:0006281,GO:0006306,GO:0006334,GO:0006336,GO:0006338,GO:0006355,GO:0007283,GO:0010571,GO:0015616,GO:0016604,GO:0016605,GO:0030330,GO:0030900,GO:0031297,GO:0032206,GO:0032508,GO:0035064,GO:0035128,GO:0035264,GO:0042393,GO:0045944,GO:0046872,GO:0060009,GO:0070087,GO:0070192,GO:0070198,GO:0072520,GO:0072711,GO:0099115,GO:1900112,GO:1901581,GO:1901582,GO:1904908" "meiotic spindle organization|nuclear chromosome|condensed chromosome, centromeric region|chromosome, telomeric region|heterochromatin|DNA binding|DNA helicase activity|chromatin binding|protein binding|ATP binding|nucleus|nucleoplasm|pericentric heterochromatin|DNA repair|DNA methylation|nucleosome assembly|DNA replication-independent nucleosome assembly|chromatin remodeling|regulation of transcription, DNA-templated|spermatogenesis|positive regulation of nuclear cell cycle DNA replication|DNA translocase activity|nuclear body|PML body|DNA damage response, signal transduction by p53 class mediator|forebrain development|replication fork processing|positive regulation of telomere maintenance|DNA duplex unwinding|methylated histone binding|post-embryonic forelimb morphogenesis|multicellular organism growth|histone binding|positive regulation of transcription by RNA polymerase II|metal ion binding|Sertoli cell development|chromo shadow domain binding|chromosome organization involved in meiotic cell cycle|protein localization to chromosome, telomeric region|seminiferous tubule development|cellular response to hydroxyurea|chromosome, subtelomeric region|regulation of histone H3-K9 trimethylation|negative regulation of telomeric RNA transcription from RNA pol II promoter|positive regulation of telomeric RNA transcription from RNA pol II promoter|negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric" other ATXN1 347.9315825 315.2454064 380.6177586 1.207369721 0.271867527 0.368336502 1 1.586278328 1.883175736 6310 ataxin 1 "GO:0000122,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006355,GO:0006396,GO:0007399,GO:0007420,GO:0007612,GO:0007613,GO:0008022,GO:0008266,GO:0016363,GO:0034046,GO:0035176,GO:0042405,GO:0042802,GO:0043621,GO:0045892,GO:0048856,GO:0051168" "negative regulation of transcription by RNA polymerase II|DNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|regulation of transcription, DNA-templated|RNA processing|nervous system development|brain development|learning|memory|protein C-terminus binding|poly(U) RNA binding|nuclear matrix|poly(G) binding|social behavior|nuclear inclusion body|identical protein binding|protein self-association|negative regulation of transcription, DNA-templated|anatomical structure development|nuclear export" "hsa04330,hsa05017,hsa05022" Notch signaling pathway|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ATXN10 2626.522542 2376.305308 2876.739776 1.210593507 0.275714518 0.243660182 1 38.50001421 45.82794769 25814 ataxin 10 "GO:0005515,GO:0005615,GO:0005737,GO:0005829,GO:0005886,GO:0007399,GO:0016020,GO:0019899,GO:0030425,GO:0031175,GO:0042802,GO:0043025,GO:0048471,GO:0060271" protein binding|extracellular space|cytoplasm|cytosol|plasma membrane|nervous system development|membrane|enzyme binding|dendrite|neuron projection development|identical protein binding|neuronal cell body|perinuclear region of cytoplasm|cilium assembly hsa05017 Spinocerebellar ataxia ATXN1L 1174.133332 1289.072801 1059.193864 0.821671098 -0.283367073 0.242753354 1 8.712695815 7.039174663 342371 ataxin 1 like "GO:0000122,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006355,GO:0007420,GO:0007612,GO:0007613,GO:0030198,GO:0030425,GO:0035176,GO:0048286,GO:0048856,GO:1902035" "negative regulation of transcription by RNA polymerase II|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription, DNA-templated|brain development|learning|memory|extracellular matrix organization|dendrite|social behavior|lung alveolus development|anatomical structure development|positive regulation of hematopoietic stem cell proliferation" "hsa04330,hsa05017,hsa05022" Notch signaling pathway|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ATXN2 1581.299923 1594.954482 1567.645364 0.982877807 -0.024916025 0.919373715 1 18.82764639 18.19561507 6311 ataxin 2 "GO:0002091,GO:0003723,GO:0005154,GO:0005515,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0005844,GO:0006417,GO:0008022,GO:0010494,GO:0010603,GO:0016020,GO:0016070,GO:0033962,GO:0034063,GO:0048471,GO:0050658,GO:1990904" negative regulation of receptor internalization|RNA binding|epidermal growth factor receptor binding|protein binding|cytoplasm|Golgi apparatus|trans-Golgi network|cytosol|polysome|regulation of translation|protein C-terminus binding|cytoplasmic stress granule|regulation of cytoplasmic mRNA processing body assembly|membrane|RNA metabolic process|P-body assembly|stress granule assembly|perinuclear region of cytoplasm|RNA transport|ribonucleoprotein complex "hsa05014,hsa05017,hsa05022" Amyotrophic lateral sclerosis|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ATXN2L 4251.075827 4564.295703 3937.855952 0.862752155 -0.212981923 0.372105292 1 50.26580125 42.64124151 11273 ataxin 2 like "GO:0003723,GO:0005515,GO:0005829,GO:0010494,GO:0010603,GO:0016020,GO:0016607,GO:0034063,GO:0045296" RNA binding|protein binding|cytosol|cytoplasmic stress granule|regulation of cytoplasmic mRNA processing body assembly|membrane|nuclear speck|stress granule assembly|cadherin binding "hsa05014,hsa05017,hsa05022" Amyotrophic lateral sclerosis|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ATXN3 272.8179933 273.6288511 272.0071355 0.994073302 -0.008575856 0.991816461 1 2.121305764 2.073446627 4287 ataxin 3 "GO:0000226,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005759,GO:0005789,GO:0005829,GO:0005886,GO:0006289,GO:0006511,GO:0006515,GO:0007268,GO:0007399,GO:0008234,GO:0010810,GO:0016363,GO:0016579,GO:0018215,GO:0030036,GO:0031625,GO:0031966,GO:0034605,GO:0035520,GO:0042405,GO:0043161,GO:0045104,GO:0045202,GO:0051117,GO:0061578,GO:0070536,GO:0071108,GO:0071218,GO:1904294,GO:1904379,GO:1990380" microtubule cytoskeleton organization|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrial matrix|endoplasmic reticulum membrane|cytosol|plasma membrane|nucleotide-excision repair|ubiquitin-dependent protein catabolic process|protein quality control for misfolded or incompletely synthesized proteins|chemical synaptic transmission|nervous system development|cysteine-type peptidase activity|regulation of cell-substrate adhesion|nuclear matrix|protein deubiquitination|protein phosphopantetheinylation|actin cytoskeleton organization|ubiquitin protein ligase binding|mitochondrial membrane|cellular response to heat|monoubiquitinated protein deubiquitination|nuclear inclusion body|proteasome-mediated ubiquitin-dependent protein catabolic process|intermediate filament cytoskeleton organization|synapse|ATPase binding|Lys63-specific deubiquitinase activity|protein K63-linked deubiquitination|protein K48-linked deubiquitination|cellular response to misfolded protein|positive regulation of ERAD pathway|protein localization to cytosolic proteasome complex involved in ERAD pathway|Lys48-specific deubiquitinase activity "hsa04141,hsa05017,hsa05022" Protein processing in endoplasmic reticulum|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ATXN7 781.3551265 856.2606254 706.4496277 0.825040422 -0.277463291 0.271888471 1 5.813135204 4.71581576 6314 ataxin 7 "GO:0000226,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006997,GO:0007026,GO:0007601,GO:0015630,GO:0016363,GO:0016578,GO:0016579" microtubule cytoskeleton organization|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|nucleus organization|negative regulation of microtubule depolymerization|visual perception|microtubule cytoskeleton|nuclear matrix|histone deubiquitination|protein deubiquitination ATXN7L1 189.019402 218.4869154 159.5518887 0.730258324 -0.453521196 0.222565804 1 0.723699423 0.519644005 222255 ataxin 7 like 1 GO:0005515 protein binding ATXN7L2 51.15891778 56.18234966 46.13548589 0.821174019 -0.284240111 0.65259284 1 0.734529334 0.593083065 127002 ataxin 7 like 2 ATXN7L3 1534.307077 1635.530624 1433.08353 0.87621932 -0.19063607 0.424468006 1 18.22619825 15.70290825 56970 ataxin 7 like 3 "GO:0000124,GO:0003713,GO:0005515,GO:0005634,GO:0006357,GO:0008270,GO:0010390,GO:0016578,GO:0030374,GO:0045893,GO:0071819" "SAGA complex|transcription coactivator activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding|histone monoubiquitination|histone deubiquitination|nuclear receptor coactivator activity|positive regulation of transcription, DNA-templated|DUBm complex" ATXN7L3B 1833.48386 1692.753387 1974.214334 1.166274041 0.221906821 0.349399214 1 11.89298804 13.63837947 552889 ataxin 7 like 3B "GO:0005515,GO:0005737,GO:0010468" protein binding|cytoplasm|regulation of gene expression AUH 413.8594699 393.2764476 434.4424921 1.104674574 0.143621428 0.621212894 1 2.150675397 2.336040691 549 AU RNA binding methylglutaconyl-CoA hydratase "GO:0003730,GO:0004300,GO:0004490,GO:0005739,GO:0005759,GO:0006552,GO:0006635,GO:0009083,GO:0050011" mRNA 3'-UTR binding|enoyl-CoA hydratase activity|methylglutaconyl-CoA hydratase activity|mitochondrion|mitochondrial matrix|leucine catabolic process|fatty acid beta-oxidation|branched-chain amino acid catabolic process|itaconyl-CoA hydratase activity hsa00280 "Valine, leucine and isoleucine degradation" AUNIP 153.4025258 153.9812546 152.823797 0.992483126 -0.01088552 0.996987441 1 3.4041825 3.3220575 79000 aurora kinase A and ninein interacting protein "GO:0000724,GO:0000922,GO:0003684,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0007051,GO:0090734,GO:2001033" double-strand break repair via homologous recombination|spindle pole|damaged DNA binding|protein binding|nucleus|cytoplasm|centrosome|spindle organization|site of DNA damage|negative regulation of double-strand break repair via nonhomologous end joining AUP1 1733.602899 1694.834215 1772.371583 1.045749235 0.064536942 0.787634094 1 62.03716534 63.78971758 550 AUP1 lipid droplet regulating VLDL assembly factor "GO:0000839,GO:0005515,GO:0005776,GO:0005783,GO:0005811,GO:0009615,GO:0016020,GO:0016032,GO:0030176,GO:0030433,GO:0030970,GO:0031410,GO:0031624,GO:0031625,GO:0034389,GO:0043130,GO:0050790,GO:0061724,GO:0070062,GO:0071712,GO:0097027,GO:0140042,GO:1990044" "Hrd1p ubiquitin ligase ERAD-L complex|protein binding|autophagosome|endoplasmic reticulum|lipid droplet|response to virus|membrane|viral process|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|cytoplasmic vesicle|ubiquitin conjugating enzyme binding|ubiquitin protein ligase binding|lipid droplet organization|ubiquitin binding|regulation of catalytic activity|lipophagy|extracellular exosome|ER-associated misfolded protein catabolic process|ubiquitin-protein transferase activator activity|lipid droplet formation|protein localization to lipid droplet" AURKA 3490.346539 3606.074517 3374.618561 0.935814983 -0.095704768 0.687424426 1 65.77223831 60.52067934 6790 aurora kinase A "GO:0000086,GO:0000278,GO:0004672,GO:0004674,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005813,GO:0005814,GO:0005819,GO:0005829,GO:0005876,GO:0005929,GO:0006468,GO:0006511,GO:0006977,GO:0007051,GO:0007052,GO:0007057,GO:0007100,GO:0009611,GO:0009948,GO:0010389,GO:0010629,GO:0010972,GO:0015630,GO:0018105,GO:0019901,GO:0030496,GO:0031145,GO:0031616,GO:0031625,GO:0031647,GO:0032091,GO:0032133,GO:0032436,GO:0032465,GO:0035174,GO:0035404,GO:0042585,GO:0043066,GO:0043203,GO:0045120,GO:0045840,GO:0046605,GO:0046777,GO:0046982,GO:0048471,GO:0051233,GO:0051301,GO:0051642,GO:0071539,GO:0072687,GO:0097421,GO:0097431,GO:0106310,GO:0106311,GO:1900195,GO:1901796,GO:1990138" "G2/M transition of mitotic cell cycle|mitotic cell cycle|protein kinase activity|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|centrosome|centriole|spindle|cytosol|spindle microtubule|cilium|protein phosphorylation|ubiquitin-dependent protein catabolic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|spindle organization|mitotic spindle organization|spindle assembly involved in female meiosis I|mitotic centrosome separation|response to wounding|anterior/posterior axis specification|regulation of G2/M transition of mitotic cell cycle|negative regulation of gene expression|negative regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|peptidyl-serine phosphorylation|protein kinase binding|midbody|anaphase-promoting complex-dependent catabolic process|spindle pole centrosome|ubiquitin protein ligase binding|regulation of protein stability|negative regulation of protein binding|chromosome passenger complex|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of cytokinesis|histone serine kinase activity|histone-serine phosphorylation|germinal vesicle|negative regulation of apoptotic process|axon hillock|pronucleus|positive regulation of mitotic nuclear division|regulation of centrosome cycle|protein autophosphorylation|protein heterodimerization activity|perinuclear region of cytoplasm|spindle midzone|cell division|centrosome localization|protein localization to centrosome|meiotic spindle|liver regeneration|mitotic spindle pole|protein serine kinase activity|protein threonine kinase activity|positive regulation of oocyte maturation|regulation of signal transduction by p53 class mediator|neuron projection extension" "hsa04114,hsa04914" Oocyte meiosis|Progesterone-mediated oocyte maturation AURKAIP1 1095.246159 971.7465664 1218.745752 1.254180662 0.326745181 0.180456334 1 56.61607888 69.81858881 54998 aurora kinase A interacting protein 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005743,GO:0005840,GO:0006397,GO:0043231,GO:0045839,GO:0045862,GO:0070125,GO:0070126" protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial inner membrane|ribosome|mRNA processing|intracellular membrane-bounded organelle|negative regulation of mitotic nuclear division|positive regulation of proteolysis|mitochondrial translational elongation|mitochondrial translational termination AURKB 2142.759156 2330.527097 1954.991214 0.838862254 -0.253494163 0.283754797 1 85.01431842 70.12193779 9212 aurora kinase B "GO:0000122,GO:0000776,GO:0000779,GO:0002903,GO:0004674,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005819,GO:0005829,GO:0005876,GO:0006468,GO:0006511,GO:0007051,GO:0007052,GO:0007094,GO:0007568,GO:0008283,GO:0008608,GO:0009838,GO:0010369,GO:0016570,GO:0019900,GO:0030496,GO:0031145,GO:0031616,GO:0032091,GO:0032133,GO:0032212,GO:0032465,GO:0032466,GO:0032467,GO:0034501,GO:0034644,GO:0035174,GO:0036089,GO:0043988,GO:0044878,GO:0046777,GO:0046872,GO:0051233,GO:0051256,GO:0051973,GO:0051983,GO:0097431,GO:0106310,GO:0106311,GO:1901796,GO:1904355,GO:1905116,GO:1990023" "negative regulation of transcription by RNA polymerase II|kinetochore|condensed chromosome, centromeric region|negative regulation of B cell apoptotic process|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|spindle|cytosol|spindle microtubule|protein phosphorylation|ubiquitin-dependent protein catabolic process|spindle organization|mitotic spindle organization|mitotic spindle assembly checkpoint|aging|cell population proliferation|attachment of spindle microtubules to kinetochore|abscission|chromocenter|histone modification|kinase binding|midbody|anaphase-promoting complex-dependent catabolic process|spindle pole centrosome|negative regulation of protein binding|chromosome passenger complex|positive regulation of telomere maintenance via telomerase|regulation of cytokinesis|negative regulation of cytokinesis|positive regulation of cytokinesis|protein localization to kinetochore|cellular response to UV|histone serine kinase activity|cleavage furrow formation|histone H3-S28 phosphorylation|mitotic cytokinesis checkpoint|protein autophosphorylation|metal ion binding|spindle midzone|mitotic spindle midzone assembly|positive regulation of telomerase activity|regulation of chromosome segregation|mitotic spindle pole|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator|positive regulation of telomere capping|positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore|mitotic spindle midzone" AURKC 11.93016111 10.40413883 13.45618338 1.29334908 0.371111717 0.792410181 1 0.507077413 0.644853711 6795 aurora kinase C "GO:0000793,GO:0004672,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005819,GO:0005876,GO:0006468,GO:0007052,GO:0007283,GO:0008608,GO:0016570,GO:0030496,GO:0031616,GO:0032133,GO:0032465,GO:0032467,GO:0035174,GO:0035404,GO:0048599,GO:0051233,GO:0051256,GO:0051301,GO:0051321,GO:0106310,GO:0106311" condensed chromosome|protein kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|spindle|spindle microtubule|protein phosphorylation|mitotic spindle organization|spermatogenesis|attachment of spindle microtubules to kinetochore|histone modification|midbody|spindle pole centrosome|chromosome passenger complex|regulation of cytokinesis|positive regulation of cytokinesis|histone serine kinase activity|histone-serine phosphorylation|oocyte development|spindle midzone|mitotic spindle midzone assembly|cell division|meiotic cell cycle|protein serine kinase activity|protein threonine kinase activity AUTS2 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.007185067 26053 activator of transcription and developmental regulator AUTS2 "GO:0001764,GO:0003682,GO:0005515,GO:0005575,GO:0005634,GO:0005737,GO:0010592,GO:0015629,GO:0030426,GO:0031532,GO:0035022,GO:0045944,GO:0048675,GO:0051571,GO:0097484,GO:2000620" neuron migration|chromatin binding|protein binding|cellular_component|nucleus|cytoplasm|positive regulation of lamellipodium assembly|actin cytoskeleton|growth cone|actin cytoskeleton reorganization|positive regulation of Rac protein signal transduction|positive regulation of transcription by RNA polymerase II|axon extension|positive regulation of histone H3-K4 methylation|dendrite extension|positive regulation of histone H4-K16 acetylation AVEN 90.99720015 80.11186896 101.8825313 1.27175327 0.346818804 0.481909471 1 1.554699348 1.944108316 57099 apoptosis and caspase activation inhibitor "GO:0005515,GO:0005829,GO:0006915,GO:0010972,GO:0012505,GO:0016020,GO:0043066" protein binding|cytosol|apoptotic process|negative regulation of G2/M transition of mitotic cell cycle|endomembrane system|membrane|negative regulation of apoptotic process AVIL 9.086322201 11.44455271 6.728091692 0.587885946 -0.766391806 0.566347083 1 0.14490504 0.083762137 10677 advillin "GO:0003779,GO:0005515,GO:0005546,GO:0005737,GO:0005884,GO:0005925,GO:0007015,GO:0007399,GO:0008154,GO:0010592,GO:0010976,GO:0015629,GO:0030027,GO:0030424,GO:0042995,GO:0043005,GO:0051014,GO:0051015,GO:0051016,GO:0060271,GO:0071933,GO:1900480" "actin binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|actin filament|focal adhesion|actin filament organization|nervous system development|actin polymerization or depolymerization|positive regulation of lamellipodium assembly|positive regulation of neuron projection development|actin cytoskeleton|lamellipodium|axon|cell projection|neuron projection|actin filament severing|actin filament binding|barbed-end actin filament capping|cilium assembly|Arp2/3 complex binding|regulation of diacylglycerol biosynthetic process" AVL9 1596.117968 1693.793801 1498.442135 0.884666206 -0.176794881 0.458238627 1 10.12485015 8.807227611 23080 AVL9 cell migration associated "GO:0005737,GO:0016021,GO:0016477,GO:0055037" cytoplasm|integral component of membrane|cell migration|recycling endosome AVPI1 421.7959378 475.4691444 368.1227311 0.774230537 -0.369164883 0.195443493 1 18.42767927 14.02852855 60370 arginine vasopressin induced 1 "GO:0000187,GO:0005515,GO:0007049" activation of MAPK activity|protein binding|cell cycle AVPR2 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.086263558 0.052239018 554 arginine vasopressin receptor 2 "GO:0001992,GO:0003091,GO:0004930,GO:0005000,GO:0005515,GO:0005768,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0007186,GO:0007188,GO:0007190,GO:0007588,GO:0007599,GO:0008285,GO:0010628,GO:0016021,GO:0030139,GO:0030665,GO:0042277,GO:0045907,GO:0048471,GO:0061024" regulation of systemic arterial blood pressure by vasopressin|renal water homeostasis|G protein-coupled receptor activity|vasopressin receptor activity|protein binding|endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|excretion|hemostasis|negative regulation of cell population proliferation|positive regulation of gene expression|integral component of membrane|endocytic vesicle|clathrin-coated vesicle membrane|peptide binding|positive regulation of vasoconstriction|perinuclear region of cytoplasm|membrane organization "hsa04072,hsa04080,hsa04962" Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|Vasopressin-regulated water reabsorption AXDND1 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.039120463 0.023690358 126859 axonemal dynein light chain domain containing 1 AXIN1 906.0223533 962.3828414 849.6618651 0.88287304 -0.179722106 0.470310177 1 9.539488013 8.281223397 8312 axin 1 "GO:0001934,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0007275,GO:0008013,GO:0010800,GO:0016055,GO:0016328,GO:0019899,GO:0019901,GO:0030111,GO:0030159,GO:0030877,GO:0031398,GO:0031410,GO:0031625,GO:0032147,GO:0033138,GO:0033146,GO:0034622,GO:0035591,GO:0042802,GO:0042803,GO:0045732,GO:0045893,GO:0046330,GO:0046332,GO:0048471,GO:0051443,GO:0060090,GO:0070016,GO:0070411,GO:0071944,GO:0090090,GO:0090263,GO:1904885,GO:1904886,GO:2000060" "positive regulation of protein phosphorylation|protein binding|nucleus|cytoplasm|cytosol|apoptotic process|multicellular organism development|beta-catenin binding|positive regulation of peptidyl-threonine phosphorylation|Wnt signaling pathway|lateral plasma membrane|enzyme binding|protein kinase binding|regulation of Wnt signaling pathway|signaling receptor complex adaptor activity|beta-catenin destruction complex|positive regulation of protein ubiquitination|cytoplasmic vesicle|ubiquitin protein ligase binding|activation of protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of intracellular estrogen receptor signaling pathway|cellular protein-containing complex assembly|signaling adaptor activity|identical protein binding|protein homodimerization activity|positive regulation of protein catabolic process|positive regulation of transcription, DNA-templated|positive regulation of JNK cascade|SMAD binding|perinuclear region of cytoplasm|positive regulation of ubiquitin-protein transferase activity|molecular adaptor activity|armadillo repeat domain binding|I-SMAD binding|cell periphery|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|beta-catenin destruction complex assembly|beta-catenin destruction complex disassembly|positive regulation of ubiquitin-dependent protein catabolic process" "hsa04310,hsa04390,hsa04550,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05210,hsa05213,hsa05217,hsa05224,hsa05225,hsa05226" Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer AXIN2 24.13772495 28.09117483 20.18427508 0.718527267 -0.476885189 0.570892056 1 0.278760575 0.196945374 8313 axin 2 "GO:0001756,GO:0001934,GO:0001957,GO:0003139,GO:0003413,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0008013,GO:0008283,GO:0008285,GO:0010718,GO:0010942,GO:0016055,GO:0019899,GO:0030282,GO:0030877,GO:0031625,GO:0032423,GO:0034613,GO:0042476,GO:0043570,GO:0045668,GO:0048255,GO:0061181,GO:0070411,GO:0070602,GO:0090090,GO:0090263,GO:1904837" somitogenesis|positive regulation of protein phosphorylation|intramembranous ossification|secondary heart field specification|chondrocyte differentiation involved in endochondral bone morphogenesis|protein binding|nucleus|cytoplasm|centrosome|cytosol|beta-catenin binding|cell population proliferation|negative regulation of cell population proliferation|positive regulation of epithelial to mesenchymal transition|positive regulation of cell death|Wnt signaling pathway|enzyme binding|bone mineralization|beta-catenin destruction complex|ubiquitin protein ligase binding|regulation of mismatch repair|cellular protein localization|odontogenesis|maintenance of DNA repeat elements|negative regulation of osteoblast differentiation|mRNA stabilization|regulation of chondrocyte development|I-SMAD binding|regulation of centromeric sister chromatid cohesion|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|beta-catenin-TCF complex assembly "hsa04310,hsa04390,hsa04550,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05210,hsa05213,hsa05217,hsa05224,hsa05225,hsa05226" Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer AXL 8991.634514 7204.866137 10778.40289 1.495989333 0.581099889 0.019923152 0.808454303 78.87394129 116.0200954 558 AXL receptor tyrosine kinase "GO:0001618,GO:0001764,GO:0001779,GO:0001786,GO:0001961,GO:0001974,GO:0004713,GO:0004714,GO:0005515,GO:0005524,GO:0005615,GO:0005886,GO:0005887,GO:0006909,GO:0006954,GO:0007165,GO:0007169,GO:0007275,GO:0007283,GO:0007399,GO:0009986,GO:0015629,GO:0016477,GO:0018108,GO:0021885,GO:0030168,GO:0031100,GO:0031668,GO:0032036,GO:0032689,GO:0032720,GO:0032825,GO:0032940,GO:0033674,GO:0034101,GO:0034446,GO:0035457,GO:0042698,GO:0043066,GO:0043231,GO:0043235,GO:0043491,GO:0043524,GO:0043548,GO:0044228,GO:0045087,GO:0046718,GO:0048010,GO:0048469,GO:0048549,GO:0051250,GO:0051897,GO:0060068,GO:0070062,GO:0070301,GO:0071222,GO:0097028,GO:0097350,GO:1903902,GO:2000669" virus receptor activity|neuron migration|natural killer cell differentiation|phosphatidylserine binding|positive regulation of cytokine-mediated signaling pathway|blood vessel remodeling|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|protein binding|ATP binding|extracellular space|plasma membrane|integral component of plasma membrane|phagocytosis|inflammatory response|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|spermatogenesis|nervous system development|cell surface|actin cytoskeleton|cell migration|peptidyl-tyrosine phosphorylation|forebrain cell migration|platelet activation|animal organ regeneration|cellular response to extracellular stimulus|myosin heavy chain binding|negative regulation of interferon-gamma production|negative regulation of tumor necrosis factor production|positive regulation of natural killer cell differentiation|secretion by cell|positive regulation of kinase activity|erythrocyte homeostasis|substrate adhesion-dependent cell spreading|cellular response to interferon-alpha|ovulation cycle|negative regulation of apoptotic process|intracellular membrane-bounded organelle|receptor complex|protein kinase B signaling|negative regulation of neuron apoptotic process|phosphatidylinositol 3-kinase binding|host cell surface|innate immune response|viral entry into host cell|vascular endothelial growth factor receptor signaling pathway|cell maturation|positive regulation of pinocytosis|negative regulation of lymphocyte activation|positive regulation of protein kinase B signaling|vagina development|extracellular exosome|cellular response to hydrogen peroxide|cellular response to lipopolysaccharide|dendritic cell differentiation|neutrophil clearance|positive regulation of viral life cycle|negative regulation of dendritic cell apoptotic process hsa01521 EGFR tyrosine kinase inhibitor resistance AZI2 1256.743669 1212.082173 1301.405164 1.073693841 0.102582674 0.672772437 1 13.53559278 14.28989114 64343 5-azacytidine induced 2 "GO:0000278,GO:0005515,GO:0005737,GO:0007249,GO:0016032,GO:0042110,GO:0044565,GO:0097028" mitotic cell cycle|protein binding|cytoplasm|I-kappaB kinase/NF-kappaB signaling|viral process|T cell activation|dendritic cell proliferation|dendritic cell differentiation hsa04622 RIG-I-like receptor signaling pathway AZIN1 6276.170678 6404.787862 6147.553495 0.959837176 -0.059138403 0.808018373 1 78.02140075 73.63469437 51582 antizyme inhibitor 1 "GO:0004586,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006521,GO:0033387,GO:0042177,GO:0042978,GO:0050790,GO:1902269" ornithine decarboxylase activity|protein binding|nucleus|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|putrescine biosynthetic process from ornithine|negative regulation of protein catabolic process|ornithine decarboxylase activator activity|regulation of catalytic activity|positive regulation of polyamine transmembrane transport AZIN2 127.6695815 109.2434577 146.0957053 1.337340546 0.419366886 0.332497711 1 1.427202584 1.876717111 113451 antizyme inhibitor 2 "GO:0004586,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005801,GO:0005802,GO:0005829,GO:0007283,GO:0008792,GO:0030133,GO:0030424,GO:0030425,GO:0031410,GO:0033116,GO:0033387,GO:0042177,GO:0042978,GO:0043085,GO:0043204,GO:0048471,GO:0097055,GO:0098629,GO:1902269,GO:1990005" ornithine decarboxylase activity|protein binding|nucleus|cytoplasm|mitochondrion|cis-Golgi network|trans-Golgi network|cytosol|spermatogenesis|arginine decarboxylase activity|transport vesicle|axon|dendrite|cytoplasmic vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|putrescine biosynthetic process from ornithine|negative regulation of protein catabolic process|ornithine decarboxylase activator activity|positive regulation of catalytic activity|perikaryon|perinuclear region of cytoplasm|agmatine biosynthetic process|trans-Golgi network membrane organization|positive regulation of polyamine transmembrane transport|granular vesicle hsa00330 Arginine and proline metabolism B2M 14277.82646 13281.92363 15273.7293 1.149963644 0.201588252 0.439890255 1 732.2643107 827.9863116 567 beta-2-microglobulin "GO:0000139,GO:0001895,GO:0001916,GO:0002237,GO:0002474,GO:0002479,GO:0002480,GO:0002481,GO:0002726,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005794,GO:0005829,GO:0005886,GO:0005925,GO:0006826,GO:0007611,GO:0009897,GO:0010977,GO:0012507,GO:0016020,GO:0019885,GO:0030670,GO:0031901,GO:0031905,GO:0032092,GO:0033077,GO:0034756,GO:0035580,GO:0042026,GO:0042493,GO:0042612,GO:0042802,GO:0042803,GO:0042824,GO:0043312,GO:0044267,GO:0045087,GO:0045646,GO:0046686,GO:0048260,GO:0050680,GO:0050690,GO:0050768,GO:0050776,GO:0051289,GO:0055038,GO:0055072,GO:0060333,GO:0070062,GO:0071281,GO:0071283,GO:0071316,GO:0090647,GO:1900121,GO:1900122,GO:1904434,GO:1904437,GO:1904724,GO:1990000,GO:1990712,GO:2000774,GO:2000978" "Golgi membrane|retina homeostasis|positive regulation of T cell mediated cytotoxicity|response to molecule of bacterial origin|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|positive regulation of T cell cytokine production|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|cytosol|plasma membrane|focal adhesion|iron ion transport|learning or memory|external side of plasma membrane|negative regulation of neuron projection development|ER to Golgi transport vesicle membrane|membrane|antigen processing and presentation of endogenous peptide antigen via MHC class I|phagocytic vesicle membrane|early endosome membrane|early endosome lumen|positive regulation of protein binding|T cell differentiation in thymus|regulation of iron ion transport|specific granule lumen|protein refolding|response to drug|MHC class I protein complex|identical protein binding|protein homodimerization activity|MHC class I peptide loading complex|neutrophil degranulation|cellular protein metabolic process|innate immune response|regulation of erythrocyte differentiation|response to cadmium ion|positive regulation of receptor-mediated endocytosis|negative regulation of epithelial cell proliferation|regulation of defense response to virus by virus|negative regulation of neurogenesis|regulation of immune response|protein homotetramerization|recycling endosome membrane|iron ion homeostasis|interferon-gamma-mediated signaling pathway|extracellular exosome|cellular response to iron ion|cellular response to iron(III) ion|cellular response to nicotine|modulation of age-related behavioral decline|negative regulation of receptor binding|positive regulation of receptor binding|positive regulation of ferrous iron binding|positive regulation of transferrin receptor binding|tertiary granule lumen|amyloid fibril formation|HFE-transferrin receptor complex|positive regulation of cellular senescence|negative regulation of forebrain neuron differentiation" "hsa04612,hsa05163,hsa05166,hsa05168,hsa05169,hsa05170" Antigen processing and presentation|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection B3GALNT1 431.0458062 478.590386 383.5012264 0.801314104 -0.319560225 0.260160364 1 5.281532111 4.161346603 8706 "beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)" "GO:0000139,GO:0005794,GO:0006486,GO:0006687,GO:0008375,GO:0008376,GO:0008499,GO:0008532,GO:0009312,GO:0016021,GO:0030311,GO:0047273" "Golgi membrane|Golgi apparatus|protein glycosylation|glycosphingolipid metabolic process|acetylglucosaminyltransferase activity|acetylgalactosaminyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|oligosaccharide biosynthetic process|integral component of membrane|poly-N-acetyllactosamine biosynthetic process|galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity" "hsa00601,hsa00603" Glycosphingolipid biosynthesis - lacto and neolacto series|Glycosphingolipid biosynthesis - globo and isoglobo series B3GALNT2 827.2321026 1000.878155 653.5860501 0.653012604 -0.614817258 0.014228816 0.708244576 6.781999442 4.354622296 148789 "beta-1,3-N-acetylgalactosaminyltransferase 2" "GO:0000139,GO:0005515,GO:0005783,GO:0005789,GO:0006486,GO:0006493,GO:0008376,GO:0016021" Golgi membrane|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein glycosylation|protein O-linked glycosylation|acetylgalactosaminyltransferase activity|integral component of membrane hsa00515 Mannose type O-glycan biosynthesis B3GALT4 30.46449659 30.1720026 30.75699059 1.019388438 0.027703895 1 1 0.945522211 0.947725611 8705 "beta-1,3-galactosyltransferase 4" "GO:0000139,GO:0001574,GO:0005794,GO:0006486,GO:0008375,GO:0008376,GO:0008499,GO:0016021,GO:0047915" "Golgi membrane|ganglioside biosynthetic process|Golgi apparatus|protein glycosylation|acetylglucosaminyltransferase activity|acetylgalactosaminyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity|integral component of membrane|ganglioside galactosyltransferase activity" hsa00604 Glycosphingolipid biosynthesis - ganglio series B3GALT6 273.2488815 297.5583704 248.9393926 0.836606923 -0.257378159 0.431947295 1 5.661370175 4.65708522 126792 "beta-1,3-galactosyltransferase 6" "GO:0000139,GO:0005794,GO:0005797,GO:0006024,GO:0006486,GO:0008499,GO:0015012,GO:0016020,GO:0016021,GO:0018215,GO:0030166,GO:0030203,GO:0030206,GO:0032580,GO:0035250,GO:0047220" "Golgi membrane|Golgi apparatus|Golgi medial cisterna|glycosaminoglycan biosynthetic process|protein glycosylation|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity|heparan sulfate proteoglycan biosynthetic process|membrane|integral component of membrane|protein phosphopantetheinylation|proteoglycan biosynthetic process|glycosaminoglycan metabolic process|chondroitin sulfate biosynthetic process|Golgi cisterna membrane|UDP-galactosyltransferase activity|galactosylxylosylprotein 3-beta-galactosyltransferase activity" "hsa00532,hsa00534" Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate|Glycosaminoglycan biosynthesis - heparan sulfate / heparin B3GALT9 112.3206543 135.2538047 89.38750391 0.660887167 -0.597524112 0.183821283 1 1.871952016 1.216447051 100288842 "beta-1,3-galactosyltransferase 9" "GO:0000139,GO:0005794,GO:0006486,GO:0008375,GO:0008376,GO:0016021" Golgi membrane|Golgi apparatus|protein glycosylation|acetylglucosaminyltransferase activity|acetylgalactosaminyltransferase activity|integral component of membrane B3GAT2 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.025288436 0.007657017 135152 "beta-1,3-glucuronyltransferase 2" "GO:0000139,GO:0005975,GO:0006486,GO:0015018,GO:0016021,GO:0030203,GO:0046872,GO:0050650" Golgi membrane|carbohydrate metabolic process|protein glycosylation|galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|integral component of membrane|glycosaminoglycan metabolic process|metal ion binding|chondroitin sulfate proteoglycan biosynthetic process hsa00515 Mannose type O-glycan biosynthesis B3GAT3 743.6379153 736.6130289 750.6628016 1.019073478 0.027258078 0.920068127 1 23.24759522 23.29457079 26229 "beta-1,3-glucuronyltransferase 3" "GO:0000139,GO:0005515,GO:0005794,GO:0005801,GO:0005975,GO:0006024,GO:0006486,GO:0015012,GO:0015018,GO:0015020,GO:0016020,GO:0016021,GO:0030203,GO:0043085,GO:0043666,GO:0046872,GO:0050650,GO:0050651,GO:0070062,GO:0072542,GO:0090316" Golgi membrane|protein binding|Golgi apparatus|cis-Golgi network|carbohydrate metabolic process|glycosaminoglycan biosynthetic process|protein glycosylation|heparan sulfate proteoglycan biosynthetic process|galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|glucuronosyltransferase activity|membrane|integral component of membrane|glycosaminoglycan metabolic process|positive regulation of catalytic activity|regulation of phosphoprotein phosphatase activity|metal ion binding|chondroitin sulfate proteoglycan biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular exosome|protein phosphatase activator activity|positive regulation of intracellular protein transport "hsa00532,hsa00534" Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate|Glycosaminoglycan biosynthesis - heparan sulfate / heparin B3GLCT 355.447223 348.5386507 362.3557954 1.039643077 0.056088318 0.860245676 1 3.968608321 4.056894214 145173 beta 3-glucosyltransferase "GO:0005789,GO:0006004,GO:0008375,GO:0016021,GO:0016757,GO:0036066" "endoplasmic reticulum membrane|fucose metabolic process|acetylglucosaminyltransferase activity|integral component of membrane|transferase activity, transferring glycosyl groups|protein O-linked fucosylation" hsa00514 Other types of O-glycan biosynthesis B3GNT2 613.7044524 580.5509465 646.8579584 1.114213942 0.156026273 0.554259782 1 10.83698391 11.8726645 10678 "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2" "GO:0000139,GO:0005515,GO:0005794,GO:0006486,GO:0007411,GO:0007608,GO:0008375,GO:0008376,GO:0008457,GO:0008532,GO:0016021,GO:0016266,GO:0018146,GO:0030311,GO:1990830" "Golgi membrane|protein binding|Golgi apparatus|protein glycosylation|axon guidance|sensory perception of smell|acetylglucosaminyltransferase activity|acetylgalactosaminyltransferase activity|beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|integral component of membrane|O-glycan processing|keratan sulfate biosynthetic process|poly-N-acetyllactosamine biosynthetic process|cellular response to leukemia inhibitory factor" "hsa00533,hsa00601" Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - lacto and neolacto series B3GNT3 11.89053214 9.363724944 14.41733934 1.539701286 0.622650484 0.600615154 1 0.18185036 0.275309893 10331 "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3" "GO:0000139,GO:0005794,GO:0005887,GO:0006486,GO:0008375,GO:0008376,GO:0008457,GO:0008532,GO:0016266,GO:0018146,GO:0018215,GO:0030311,GO:0047223" "Golgi membrane|Golgi apparatus|integral component of plasma membrane|protein glycosylation|acetylglucosaminyltransferase activity|acetylgalactosaminyltransferase activity|beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|O-glycan processing|keratan sulfate biosynthetic process|protein phosphopantetheinylation|poly-N-acetyllactosamine biosynthetic process|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity" hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series B3GNT4 16.33462083 12.48496659 20.18427508 1.616686351 0.693039812 0.478670235 1 0.230473788 0.366368806 79369 "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4" "GO:0000139,GO:0005794,GO:0006486,GO:0008375,GO:0008376,GO:0008457,GO:0008532,GO:0016021,GO:0016266,GO:0018146,GO:0030311" "Golgi membrane|Golgi apparatus|protein glycosylation|acetylglucosaminyltransferase activity|acetylgalactosaminyltransferase activity|beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|integral component of membrane|O-glycan processing|keratan sulfate biosynthetic process|poly-N-acetyllactosamine biosynthetic process" hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series B3GNT5 969.959346 912.4429751 1027.475717 1.126071157 0.171297995 0.488622099 1 6.781145325 7.508273173 84002 "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5" "GO:0000139,GO:0005515,GO:0005794,GO:0006486,GO:0007417,GO:0007420,GO:0008375,GO:0008376,GO:0008457,GO:0009247,GO:0016021,GO:0016266,GO:0047256" "Golgi membrane|protein binding|Golgi apparatus|protein glycosylation|central nervous system development|brain development|acetylglucosaminyltransferase activity|acetylgalactosaminyltransferase activity|beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|glycolipid biosynthetic process|integral component of membrane|O-glycan processing|lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity" hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series B3GNT7 14.88785648 24.96993318 4.80577978 0.192462661 -2.377349516 0.019545902 0.80560651 0.366199352 0.069300319 93010 "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7" "GO:0000139,GO:0005515,GO:0005794,GO:0006486,GO:0008375,GO:0008376,GO:0008532,GO:0016021,GO:0016266,GO:0018146,GO:0030311" "Golgi membrane|protein binding|Golgi apparatus|protein glycosylation|acetylglucosaminyltransferase activity|acetylgalactosaminyltransferase activity|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|integral component of membrane|O-glycan processing|keratan sulfate biosynthetic process|poly-N-acetyllactosamine biosynthetic process" hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate B3GNT9 397.0392406 393.2764476 400.8020336 1.019135613 0.027346039 0.934096717 1 7.767742857 7.783913425 84752 "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9" "GO:0000139,GO:0005794,GO:0006486,GO:0008375,GO:0008376,GO:0008532,GO:0016021,GO:0030311" "Golgi membrane|Golgi apparatus|protein glycosylation|acetylglucosaminyltransferase activity|acetylgalactosaminyltransferase activity|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|integral component of membrane|poly-N-acetyllactosamine biosynthetic process" B3GNTL1 281.3991999 246.5780902 316.2203095 1.282434742 0.358885415 0.266640004 1 2.426594041 3.059874259 146712 "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1" GO:0016757 "transferase activity, transferring glycosyl groups" B4GALNT1 1079.253108 1006.080225 1152.425991 1.145461329 0.195928754 0.423342143 1 8.037822228 9.052947614 2583 "beta-1,4-N-acetyl-galactosaminyltransferase 1" "GO:0000139,GO:0001574,GO:0003947,GO:0005794,GO:0005886,GO:0005975,GO:0006687,GO:0007283,GO:0008376,GO:0016020,GO:0019915,GO:0030173,GO:0030259" Golgi membrane|ganglioside biosynthetic process|(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity|Golgi apparatus|plasma membrane|carbohydrate metabolic process|glycosphingolipid metabolic process|spermatogenesis|acetylgalactosaminyltransferase activity|membrane|lipid storage|integral component of Golgi membrane|lipid glycosylation hsa00604 Glycosphingolipid biosynthesis - ganglio series B4GALNT4 715.6115215 619.0462602 812.1767828 1.31198076 0.391746563 0.125081396 1 6.326572414 8.161446313 338707 "beta-1,4-N-acetyl-galactosaminyltransferase 4" "GO:0008376,GO:0016021,GO:0018215,GO:0032580,GO:0033842" acetylgalactosaminyltransferase activity|integral component of membrane|protein phosphopantetheinylation|Golgi cisterna membrane|N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity hsa00513 Various types of N-glycan biosynthesis B4GALT1 3645.689656 4012.876345 3278.502966 0.816995762 -0.291599501 0.219702659 1 45.52717585 36.57309322 2683 "beta-1,4-galactosyltransferase 1" "GO:0000138,GO:0000139,GO:0002064,GO:0002526,GO:0003831,GO:0003945,GO:0004461,GO:0005615,GO:0005794,GO:0005886,GO:0005989,GO:0006012,GO:0006487,GO:0007155,GO:0007339,GO:0007341,GO:0008285,GO:0008378,GO:0009312,GO:0009897,GO:0016020,GO:0016021,GO:0016323,GO:0018146,GO:0030057,GO:0030145,GO:0030175,GO:0030198,GO:0030667,GO:0031526,GO:0032580,GO:0035250,GO:0035577,GO:0043065,GO:0043312,GO:0045136,GO:0050900,GO:0060046,GO:0060054,GO:0060055,GO:0070062" "Golgi trans cisterna|Golgi membrane|epithelial cell development|acute inflammatory response|beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|N-acetyllactosamine synthase activity|lactose synthase activity|extracellular space|Golgi apparatus|plasma membrane|lactose biosynthetic process|galactose metabolic process|protein N-linked glycosylation|cell adhesion|binding of sperm to zona pellucida|penetration of zona pellucida|negative regulation of cell population proliferation|galactosyltransferase activity|oligosaccharide biosynthetic process|external side of plasma membrane|membrane|integral component of membrane|basolateral plasma membrane|keratan sulfate biosynthetic process|desmosome|manganese ion binding|filopodium|extracellular matrix organization|secretory granule membrane|brush border membrane|Golgi cisterna membrane|UDP-galactosyltransferase activity|azurophil granule membrane|positive regulation of apoptotic process|neutrophil degranulation|development of secondary sexual characteristics|leukocyte migration|regulation of acrosome reaction|positive regulation of epithelial cell proliferation involved in wound healing|angiogenesis involved in wound healing|extracellular exosome" "hsa00052,hsa00510,hsa00513,hsa00514,hsa00515,hsa00533,hsa00601" Galactose metabolism|N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Other types of O-glycan biosynthesis|Mannose type O-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - lacto and neolacto series B4GALT2 1248.469433 1272.426178 1224.512688 0.962344778 -0.055374236 0.821439929 1 27.3377804 25.86813526 8704 "beta-1,4-galactosyltransferase 2" "GO:0000139,GO:0003831,GO:0003945,GO:0004461,GO:0005654,GO:0005794,GO:0005975,GO:0006486,GO:0007613,GO:0007626,GO:0008378,GO:0008542,GO:0016021,GO:0018146,GO:0021680,GO:0032580,GO:0043231,GO:0046872" "Golgi membrane|beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|N-acetyllactosamine synthase activity|lactose synthase activity|nucleoplasm|Golgi apparatus|carbohydrate metabolic process|protein glycosylation|memory|locomotory behavior|galactosyltransferase activity|visual learning|integral component of membrane|keratan sulfate biosynthetic process|cerebellar Purkinje cell layer development|Golgi cisterna membrane|intracellular membrane-bounded organelle|metal ion binding" "hsa00052,hsa00510,hsa00513,hsa00514,hsa00515,hsa00533,hsa00601" Galactose metabolism|N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Other types of O-glycan biosynthesis|Mannose type O-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - lacto and neolacto series B4GALT3 1410.988464 1362.942186 1459.034741 1.070503765 0.098289869 0.683300035 1 32.09961143 33.78774071 8703 "beta-1,4-galactosyltransferase 3" "GO:0000139,GO:0003831,GO:0003945,GO:0005794,GO:0005829,GO:0005975,GO:0006486,GO:0006682,GO:0008378,GO:0016021,GO:0018146,GO:0032580,GO:0046872,GO:0070062" "Golgi membrane|beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|N-acetyllactosamine synthase activity|Golgi apparatus|cytosol|carbohydrate metabolic process|protein glycosylation|galactosylceramide biosynthetic process|galactosyltransferase activity|integral component of membrane|keratan sulfate biosynthetic process|Golgi cisterna membrane|metal ion binding|extracellular exosome" "hsa00510,hsa00513,hsa00514,hsa00515,hsa00533,hsa00601" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Other types of O-glycan biosynthesis|Mannose type O-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - lacto and neolacto series B4GALT4 688.6343737 680.4306792 696.8380681 1.024113241 0.034375249 0.899266883 1 12.34727466 12.43341039 8702 "beta-1,4-galactosyltransferase 4" "GO:0000139,GO:0003945,GO:0005794,GO:0005975,GO:0006486,GO:0006643,GO:0008378,GO:0016021,GO:0018146,GO:0032580,GO:0046872" Golgi membrane|N-acetyllactosamine synthase activity|Golgi apparatus|carbohydrate metabolic process|protein glycosylation|membrane lipid metabolic process|galactosyltransferase activity|integral component of membrane|keratan sulfate biosynthetic process|Golgi cisterna membrane|metal ion binding "hsa00533,hsa00601" Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - lacto and neolacto series B4GALT5 3556.388283 3699.711767 3413.0648 0.922521811 -0.116345074 0.624628837 1 41.8142349 37.92905096 9334 "beta-1,4-galactosyltransferase 5" "GO:0000139,GO:0003945,GO:0006486,GO:0008378,GO:0008489,GO:0010706,GO:0016021,GO:0016266,GO:0018146,GO:0021955,GO:0022010,GO:0030311,GO:0031647,GO:0032580,GO:0040019,GO:0042551,GO:0046872" "Golgi membrane|N-acetyllactosamine synthase activity|protein glycosylation|galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity|ganglioside biosynthetic process via lactosylceramide|integral component of membrane|O-glycan processing|keratan sulfate biosynthetic process|central nervous system neuron axonogenesis|central nervous system myelination|poly-N-acetyllactosamine biosynthetic process|regulation of protein stability|Golgi cisterna membrane|positive regulation of embryonic development|neuron maturation|metal ion binding" hsa00512 Mucin type O-glycan biosynthesis B4GALT6 976.4496639 906.2004918 1046.698836 1.155041126 0.20794422 0.39960085 1 6.63951877 7.54058829 9331 "beta-1,4-galactosyltransferase 6" "GO:0000139,GO:0001572,GO:0005975,GO:0006486,GO:0008378,GO:0008489,GO:0010706,GO:0016021,GO:0018146,GO:0021955,GO:0022010,GO:0032580,GO:0042551,GO:0046872" "Golgi membrane|lactosylceramide biosynthetic process|carbohydrate metabolic process|protein glycosylation|galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity|ganglioside biosynthetic process via lactosylceramide|integral component of membrane|keratan sulfate biosynthetic process|central nervous system neuron axonogenesis|central nervous system myelination|Golgi cisterna membrane|neuron maturation|metal ion binding" hsa00600 Sphingolipid metabolism B4GALT7 422.1330911 433.8525891 410.4135932 0.945974747 -0.080126424 0.78560192 1 11.58274902 10.77363772 11285 "beta-1,4-galactosyltransferase 7" "GO:0000139,GO:0003831,GO:0005515,GO:0005794,GO:0005975,GO:0006024,GO:0006029,GO:0006464,GO:0006487,GO:0008378,GO:0016021,GO:0018215,GO:0030145,GO:0030203,GO:0032580,GO:0046525,GO:0048147,GO:0097435" "Golgi membrane|beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|protein binding|Golgi apparatus|carbohydrate metabolic process|glycosaminoglycan biosynthetic process|proteoglycan metabolic process|cellular protein modification process|protein N-linked glycosylation|galactosyltransferase activity|integral component of membrane|protein phosphopantetheinylation|manganese ion binding|glycosaminoglycan metabolic process|Golgi cisterna membrane|xylosylprotein 4-beta-galactosyltransferase activity|negative regulation of fibroblast proliferation|supramolecular fiber organization" "hsa00532,hsa00534" Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate|Glycosaminoglycan biosynthesis - heparan sulfate / heparin B4GAT1 585.6478762 537.8939773 633.401775 1.177558779 0.235799075 0.373543164 1 14.30314547 16.56095316 11041 "beta-1,4-glucuronyltransferase 1" "GO:0000139,GO:0005515,GO:0005794,GO:0006493,GO:0008532,GO:0015020,GO:0018146,GO:0030173,GO:0030311,GO:0035269,GO:0046872,GO:0070062" "Golgi membrane|protein binding|Golgi apparatus|protein O-linked glycosylation|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|glucuronosyltransferase activity|keratan sulfate biosynthetic process|integral component of Golgi membrane|poly-N-acetyllactosamine biosynthetic process|protein O-linked mannosylation|metal ion binding|extracellular exosome" hsa00515 Mannose type O-glycan biosynthesis B9D1 294.106849 315.2454064 272.9682915 0.865891416 -0.207741974 0.516089164 1 2.457862373 2.092628685 27077 B9 domain containing 1 "GO:0005515,GO:0005813,GO:0005829,GO:0007224,GO:0008158,GO:0035869,GO:0036038,GO:0036064,GO:0060271,GO:0097711" protein binding|centrosome|cytosol|smoothened signaling pathway|hedgehog receptor activity|ciliary transition zone|MKS complex|ciliary basal body|cilium assembly|ciliary basal body-plasma membrane docking B9D2 20.49627636 20.80827765 20.18427508 0.97001181 -0.043925782 1 1 0.945911017 0.902190988 80776 B9 domain containing 2 "GO:0005515,GO:0005634,GO:0005813,GO:0005829,GO:0016020,GO:0036038,GO:0036064,GO:0043015,GO:0060271,GO:0097711" protein binding|nucleus|centrosome|cytosol|membrane|MKS complex|ciliary basal body|gamma-tubulin binding|cilium assembly|ciliary basal body-plasma membrane docking BABAM1 1370.848241 1293.234456 1448.462026 1.120030493 0.163538011 0.496337977 1 49.15779634 54.13690595 29086 BRISC and BRCA1 A complex member 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006302,GO:0006303,GO:0006325,GO:0007049,GO:0010212,GO:0016579,GO:0016604,GO:0045739,GO:0051301,GO:0070531,GO:0070536,GO:0070552,GO:0072425" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|double-strand break repair|double-strand break repair via nonhomologous end joining|chromatin organization|cell cycle|response to ionizing radiation|protein deubiquitination|nuclear body|positive regulation of DNA repair|cell division|BRCA1-A complex|protein K63-linked deubiquitination|BRISC complex|signal transduction involved in G2 DNA damage checkpoint hsa03440 Homologous recombination BABAM2 847.4320833 862.5031087 832.3610579 0.965052821 -0.051320187 0.841637398 1 20.84701345 19.7818138 9577 BRISC and BRCA1 A complex member 2 "GO:0000152,GO:0000268,GO:0005164,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006302,GO:0006303,GO:0006325,GO:0006915,GO:0006974,GO:0007049,GO:0007165,GO:0010212,GO:0016579,GO:0031593,GO:0043066,GO:0045739,GO:0051301,GO:0070531,GO:0070536,GO:0070552,GO:0072425" nuclear ubiquitin ligase complex|peroxisome targeting sequence binding|tumor necrosis factor receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|double-strand break repair|double-strand break repair via nonhomologous end joining|chromatin organization|apoptotic process|cellular response to DNA damage stimulus|cell cycle|signal transduction|response to ionizing radiation|protein deubiquitination|polyubiquitin modification-dependent protein binding|negative regulation of apoptotic process|positive regulation of DNA repair|cell division|BRCA1-A complex|protein K63-linked deubiquitination|BRISC complex|signal transduction involved in G2 DNA damage checkpoint hsa03440 Homologous recombination BACE1 446.1318075 508.7623886 383.5012264 0.753792409 -0.407760829 0.146573462 1 4.593421352 3.40454613 23621 beta-secretase 1 "GO:0001540,GO:0004175,GO:0004190,GO:0005515,GO:0005764,GO:0005768,GO:0005769,GO:0005770,GO:0005771,GO:0005788,GO:0005794,GO:0005802,GO:0005886,GO:0005887,GO:0006508,GO:0006509,GO:0008021,GO:0008233,GO:0008798,GO:0009314,GO:0009986,GO:0010008,GO:0010288,GO:0016020,GO:0016021,GO:0016485,GO:0019899,GO:0030424,GO:0030425,GO:0030659,GO:0034205,GO:0042987,GO:0043025,GO:0043525,GO:0044267,GO:0045121,GO:0050435,GO:0050966,GO:0055037,GO:0060134,GO:0070931,GO:0071280,GO:0071287,GO:0098686,GO:1904646,GO:2000300" amyloid-beta binding|endopeptidase activity|aspartic-type endopeptidase activity|protein binding|lysosome|endosome|early endosome|late endosome|multivesicular body|endoplasmic reticulum lumen|Golgi apparatus|trans-Golgi network|plasma membrane|integral component of plasma membrane|proteolysis|membrane protein ectodomain proteolysis|synaptic vesicle|peptidase activity|beta-aspartyl-peptidase activity|response to radiation|cell surface|endosome membrane|response to lead ion|membrane|integral component of membrane|protein processing|enzyme binding|axon|dendrite|cytoplasmic vesicle membrane|amyloid-beta formation|amyloid precursor protein catabolic process|neuronal cell body|positive regulation of neuron apoptotic process|cellular protein metabolic process|membrane raft|amyloid-beta metabolic process|detection of mechanical stimulus involved in sensory perception of pain|recycling endosome|prepulse inhibition|Golgi-associated vesicle lumen|cellular response to copper ion|cellular response to manganese ion|hippocampal mossy fiber to CA3 synapse|cellular response to amyloid-beta|regulation of synaptic vesicle exocytosis hsa05010 Alzheimer disease BACE2 12.25222323 6.242483296 18.26196316 2.925432444 1.548649903 0.150303853 1 0.137042312 0.394199373 25825 beta-secretase 2 "GO:0004190,GO:0005515,GO:0005768,GO:0005783,GO:0005794,GO:0005802,GO:0005886,GO:0006508,GO:0006509,GO:0016020,GO:0016021,GO:0016486,GO:0031045,GO:0042593,GO:0042985,GO:0048143,GO:0050435" aspartic-type endopeptidase activity|protein binding|endosome|endoplasmic reticulum|Golgi apparatus|trans-Golgi network|plasma membrane|proteolysis|membrane protein ectodomain proteolysis|membrane|integral component of membrane|peptide hormone processing|dense core granule|glucose homeostasis|negative regulation of amyloid precursor protein biosynthetic process|astrocyte activation|amyloid-beta metabolic process hsa05010 Alzheimer disease BACH1 2684.040987 2750.854306 2617.227668 0.951423586 -0.071840304 0.762407385 1 25.12975667 23.50895774 571 BTB domain and CNC homolog 1 "GO:0000083,GO:0000117,GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006281,GO:0006355,GO:0006357,GO:0020037,GO:0045944,GO:0061418" "regulation of transcription involved in G1/S transition of mitotic cell cycle|regulation of transcription involved in G2/M transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|cytoplasm|cytosol|DNA repair|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|heme binding|positive regulation of transcription by RNA polymerase II|regulation of transcription from RNA polymerase II promoter in response to hypoxia" TF_bZIP BACH2 190.0598159 220.5677431 159.5518887 0.723369095 -0.467196133 0.207813878 1 0.676588979 0.481233717 60468 BTB domain and CNC homolog 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0051170,GO:0090721,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|import into nucleus|primary adaptive immune response involving T cells and B cells|sequence-specific double-stranded DNA binding" TF_bZIP BAD 980.1961369 752.2192372 1208.173037 1.606144827 0.683601988 0.005621848 0.45516052 43.11982617 68.09776891 572 BCL2 associated agonist of cell death "GO:0001836,GO:0001844,GO:0005515,GO:0005543,GO:0005739,GO:0005741,GO:0005829,GO:0006007,GO:0006915,GO:0006919,GO:0007283,GO:0008289,GO:0008625,GO:0008630,GO:0008656,GO:0009749,GO:0010508,GO:0010918,GO:0019050,GO:0019221,GO:0019901,GO:0019903,GO:0021987,GO:0030346,GO:0032024,GO:0032355,GO:0032570,GO:0033133,GO:0033574,GO:0034201,GO:0035774,GO:0042493,GO:0042542,GO:0042593,GO:0043065,GO:0043200,GO:0043280,GO:0043422,GO:0044342,GO:0045471,GO:0045579,GO:0045582,GO:0045862,GO:0046031,GO:0046034,GO:0046902,GO:0046931,GO:0050679,GO:0051384,GO:0051592,GO:0060139,GO:0071247,GO:0071260,GO:0071316,GO:0071396,GO:0071456,GO:0071889,GO:0090200,GO:0097191,GO:0097192,GO:0097193,GO:0097202,GO:1900740,GO:1901216,GO:1901423,GO:1902220,GO:1904710,GO:2000078,GO:2001244" release of cytochrome c from mitochondria|protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|protein binding|phospholipid binding|mitochondrion|mitochondrial outer membrane|cytosol|glucose catabolic process|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|spermatogenesis|lipid binding|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|cysteine-type endopeptidase activator activity involved in apoptotic process|response to glucose|positive regulation of autophagy|positive regulation of mitochondrial membrane potential|suppression by virus of host apoptotic process|cytokine-mediated signaling pathway|protein kinase binding|protein phosphatase binding|cerebral cortex development|protein phosphatase 2B binding|positive regulation of insulin secretion|response to estradiol|response to progesterone|positive regulation of glucokinase activity|response to testosterone|response to oleic acid|positive regulation of insulin secretion involved in cellular response to glucose stimulus|response to drug|response to hydrogen peroxide|glucose homeostasis|positive regulation of apoptotic process|response to amino acid|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein kinase B binding|type B pancreatic cell proliferation|response to ethanol|positive regulation of B cell differentiation|positive regulation of T cell differentiation|positive regulation of proteolysis|ADP metabolic process|ATP metabolic process|regulation of mitochondrial membrane permeability|pore complex assembly|positive regulation of epithelial cell proliferation|response to glucocorticoid|response to calcium ion|positive regulation of apoptotic process by virus|cellular response to chromate|cellular response to mechanical stimulus|cellular response to nicotine|cellular response to lipid|cellular response to hypoxia|14-3-3 protein binding|positive regulation of release of cytochrome c from mitochondria|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|intrinsic apoptotic signaling pathway|activation of cysteine-type endopeptidase activity|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of neuron death|response to benzene|positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|positive regulation of granulosa cell apoptotic process|positive regulation of type B pancreatic cell development|positive regulation of intrinsic apoptotic signaling pathway "hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04022,hsa04024,hsa04062,hsa04140,hsa04151,hsa04210,hsa04370,hsa04510,hsa04722,hsa04910,hsa04919,hsa05010,hsa05014,hsa05020,hsa05022,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05165,hsa05168,hsa05170,hsa05200,hsa05203,hsa05210,hsa05211,hsa05212,hsa05213,hsa05215,hsa05218,hsa05220,hsa05221,hsa05223,hsa05225" EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Autophagy - animal|PI3K-Akt signaling pathway|Apoptosis|VEGF signaling pathway|Focal adhesion|Neurotrophin signaling pathway|Insulin signaling pathway|Thyroid hormone signaling pathway|Alzheimer disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human papillomavirus infection|Herpes simplex virus 1 infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Hepatocellular carcinoma BAG1 428.5441511 425.529278 431.5590242 1.014169991 0.020299492 0.951977173 1 5.944951696 5.928301254 573 BAG cochaperone 1 "GO:0000774,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0007166,GO:0016020,GO:0031072,GO:0031625,GO:0043066,GO:0050790,GO:0050821,GO:0051085,GO:0051087,GO:1900034" adenyl-nucleotide exchange factor activity|protein binding|nucleus|cytoplasm|cytosol|apoptotic process|cell surface receptor signaling pathway|membrane|heat shock protein binding|ubiquitin protein ligase binding|negative regulation of apoptotic process|regulation of catalytic activity|protein stabilization|chaperone cofactor-dependent protein refolding|chaperone binding|regulation of cellular response to heat hsa04141 Protein processing in endoplasmic reticulum BAG2 353.0839621 349.5790646 356.5888597 1.020052102 0.028642844 0.933919769 1 6.766917728 6.787102846 9532 BAG cochaperone 2 "GO:0000774,GO:0005515,GO:0005829,GO:0005874,GO:0006457,GO:0010954,GO:0019538,GO:0030424,GO:0030425,GO:0031072,GO:0031397,GO:0031625,GO:0032091,GO:0032436,GO:0042802,GO:0044325,GO:0048156,GO:0050821,GO:0051087,GO:0101031,GO:1900034,GO:1901588,GO:1901800,GO:1904667" adenyl-nucleotide exchange factor activity|protein binding|cytosol|microtubule|protein folding|positive regulation of protein processing|protein metabolic process|axon|dendrite|heat shock protein binding|negative regulation of protein ubiquitination|ubiquitin protein ligase binding|negative regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|identical protein binding|ion channel binding|tau protein binding|protein stabilization|chaperone binding|chaperone complex|regulation of cellular response to heat|dendritic microtubule|positive regulation of proteasomal protein catabolic process|negative regulation of ubiquitin protein ligase activity hsa04141 Protein processing in endoplasmic reticulum BAG3 978.5600598 936.3724944 1020.747625 1.090108511 0.12447175 0.615612384 1 19.51287741 20.91520978 9531 BAG cochaperone 3 "GO:0000045,GO:0000774,GO:0001725,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0007420,GO:0008625,GO:0010664,GO:0016020,GO:0016235,GO:0021510,GO:0030018,GO:0031072,GO:0034605,GO:0034620,GO:0042307,GO:0043005,GO:0043066,GO:0044877,GO:0045296,GO:0045505,GO:0046716,GO:0046827,GO:0050790,GO:0050821,GO:0051087,GO:0061684,GO:0070842,GO:0071260,GO:0072321,GO:0097192,GO:0097201,GO:0098840,GO:0101031,GO:1900034,GO:1903215,GO:1905337" autophagosome assembly|adenyl-nucleotide exchange factor activity|stress fiber|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|protein folding|brain development|extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of striated muscle cell apoptotic process|membrane|aggresome|spinal cord development|Z disc|heat shock protein binding|cellular response to heat|cellular response to unfolded protein|positive regulation of protein import into nucleus|neuron projection|negative regulation of apoptotic process|protein-containing complex binding|cadherin binding|dynein intermediate chain binding|muscle cell cellular homeostasis|positive regulation of protein export from nucleus|regulation of catalytic activity|protein stabilization|chaperone binding|chaperone-mediated autophagy|aggresome assembly|cellular response to mechanical stimulus|chaperone-mediated protein transport|extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of transcription from RNA polymerase II promoter in response to stress|protein transport along microtubule|chaperone complex|regulation of cellular response to heat|negative regulation of protein targeting to mitochondrion|positive regulation of aggrephagy BAG4 488.1156987 475.4691444 500.7622531 1.05319611 0.074774097 0.79196633 1 6.045964822 6.261033691 9530 BAG cochaperone 4 "GO:0000774,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0010763,GO:0016020,GO:0030838,GO:0031072,GO:0031625,GO:0033138,GO:0033209,GO:0043066,GO:0044877,GO:0045785,GO:0050821,GO:0051087,GO:0051496,GO:0051897,GO:0071356,GO:0071364,GO:0072659,GO:0090367,GO:0097178,GO:1900034,GO:1903215,GO:2001145" "adenyl-nucleotide exchange factor activity|RNA binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|protein folding|positive regulation of fibroblast migration|membrane|positive regulation of actin filament polymerization|heat shock protein binding|ubiquitin protein ligase binding|positive regulation of peptidyl-serine phosphorylation|tumor necrosis factor-mediated signaling pathway|negative regulation of apoptotic process|protein-containing complex binding|positive regulation of cell adhesion|protein stabilization|chaperone binding|positive regulation of stress fiber assembly|positive regulation of protein kinase B signaling|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|protein localization to plasma membrane|negative regulation of mRNA modification|ruffle assembly|regulation of cellular response to heat|negative regulation of protein targeting to mitochondrion|negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity" hsa04668 TNF signaling pathway BAG5 1391.36341 1465.943161 1316.78366 0.898250147 -0.154810828 0.519274663 1 15.36423649 13.56998785 9529 BAG cochaperone 5 "GO:0000774,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006457,GO:0007030,GO:0010977,GO:0016020,GO:0016234,GO:0019901,GO:0031072,GO:0031397,GO:0031625,GO:0032435,GO:0048471,GO:0050821,GO:0051087,GO:0051438,GO:0051444,GO:0061084,GO:0070997,GO:0090083,GO:1900034,GO:1902176" adenyl-nucleotide exchange factor activity|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|protein folding|Golgi organization|negative regulation of neuron projection development|membrane|inclusion body|protein kinase binding|heat shock protein binding|negative regulation of protein ubiquitination|ubiquitin protein ligase binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|perinuclear region of cytoplasm|protein stabilization|chaperone binding|regulation of ubiquitin-protein transferase activity|negative regulation of ubiquitin-protein transferase activity|negative regulation of protein refolding|neuron death|regulation of inclusion body assembly|regulation of cellular response to heat|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway BAG6 3654.862724 3610.236173 3699.489275 1.024722234 0.035232898 0.883184681 1 38.57290675 38.86509246 7917 BAG cochaperone 6 "GO:0001822,GO:0002429,GO:0005102,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006325,GO:0006511,GO:0006915,GO:0007130,GO:0007283,GO:0007420,GO:0010498,GO:0016020,GO:0018393,GO:0030101,GO:0030154,GO:0030324,GO:0030433,GO:0031593,GO:0031625,GO:0032435,GO:0042771,GO:0043022,GO:0043231,GO:0045861,GO:0045995,GO:0050821,GO:0051787,GO:0061857,GO:0070059,GO:0070062,GO:0070628,GO:0071712,GO:0071816,GO:0071818,GO:1904294,GO:1904378,GO:1904379,GO:1990381" kidney development|immune response-activating cell surface receptor signaling pathway|signaling receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|chromatin organization|ubiquitin-dependent protein catabolic process|apoptotic process|synaptonemal complex assembly|spermatogenesis|brain development|proteasomal protein catabolic process|membrane|internal peptidyl-lysine acetylation|natural killer cell activation|cell differentiation|lung development|ubiquitin-dependent ERAD pathway|polyubiquitin modification-dependent protein binding|ubiquitin protein ligase binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|ribosome binding|intracellular membrane-bounded organelle|negative regulation of proteolysis|regulation of embryonic development|protein stabilization|misfolded protein binding|endoplasmic reticulum stress-induced pre-emptive quality control|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|extracellular exosome|proteasome binding|ER-associated misfolded protein catabolic process|tail-anchored membrane protein insertion into ER membrane|BAT3 complex|positive regulation of ERAD pathway|maintenance of unfolded protein involved in ERAD pathway|protein localization to cytosolic proteasome complex involved in ERAD pathway|ubiquitin-specific protease binding BAHCC1 264.1279608 272.5884373 255.6674843 0.937924906 -0.092455676 0.788306716 1 1.318428847 1.215894639 57597 BAH domain and coiled-coil containing 1 GO:0003682 chromatin binding BAHD1 608.6659293 561.8234966 655.508362 1.166751419 0.222497222 0.397796326 1 5.725317439 6.568241121 22893 bromo adjacent homology domain containing 1 "GO:0003682,GO:0005515,GO:0005654,GO:0005677,GO:0005694,GO:0031507,GO:0045892" "chromatin binding|protein binding|nucleoplasm|chromatin silencing complex|chromosome|heterochromatin assembly|negative regulation of transcription, DNA-templated" BAIAP2 776.9858797 766.7850315 787.186728 1.026606801 0.037883723 0.885816824 1 5.356971834 5.407476969 10458 BAR/IMD domain containing adaptor protein 2 "GO:0001726,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0007009,GO:0007409,GO:0008022,GO:0008093,GO:0008286,GO:0008360,GO:0009617,GO:0015629,GO:0030175,GO:0030838,GO:0032956,GO:0038096,GO:0042802,GO:0048010,GO:0051017,GO:0051764,GO:0070062,GO:0070064,GO:0098609,GO:0098641,GO:2000251" ruffle|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|adherens junction|plasma membrane organization|axonogenesis|protein C-terminus binding|cytoskeletal anchor activity|insulin receptor signaling pathway|regulation of cell shape|response to bacterium|actin cytoskeleton|filopodium|positive regulation of actin filament polymerization|regulation of actin cytoskeleton organization|Fc-gamma receptor signaling pathway involved in phagocytosis|identical protein binding|vascular endothelial growth factor receptor signaling pathway|actin filament bundle assembly|actin crosslink formation|extracellular exosome|proline-rich region binding|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|positive regulation of actin cytoskeleton reorganization "hsa04520,hsa04810,hsa05130,hsa05135" Adherens junction|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Yersinia infection BAIAP2L1 2064.872154 2115.161423 2014.582884 0.952448764 -0.070286608 0.76787602 1 30.96907481 29.00287376 55971 BAR/IMD domain containing adaptor protein 2 like 1 "GO:0003779,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0005912,GO:0007009,GO:0009617,GO:0015629,GO:0030838,GO:0046626,GO:0051017,GO:0051764,GO:0070062,GO:0070064,GO:0098609,GO:0098641,GO:2000251" actin binding|protein binding|nucleoplasm|cytosol|plasma membrane|adherens junction|plasma membrane organization|response to bacterium|actin cytoskeleton|positive regulation of actin filament polymerization|regulation of insulin receptor signaling pathway|actin filament bundle assembly|actin crosslink formation|extracellular exosome|proline-rich region binding|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|positive regulation of actin cytoskeleton reorganization hsa05130 Pathogenic Escherichia coli infection BAIAP2L2 5.965080553 5.202069413 6.728091692 1.29334908 0.371111717 0.919461532 1 0.082552746 0.104982874 80115 BAR/IMD domain containing adaptor protein 2 like 2 "GO:0005543,GO:0005654,GO:0005829,GO:0005886,GO:0007009,GO:0012506,GO:0030659,GO:0030838,GO:0044291,GO:0051017,GO:0051764,GO:0061024,GO:0071439,GO:2000251" phospholipid binding|nucleoplasm|cytosol|plasma membrane|plasma membrane organization|vesicle membrane|cytoplasmic vesicle membrane|positive regulation of actin filament polymerization|cell-cell contact zone|actin filament bundle assembly|actin crosslink formation|membrane organization|clathrin complex|positive regulation of actin cytoskeleton reorganization BAIAP3 34.98784321 35.37407201 34.60161442 0.97816317 -0.03185295 1 1 0.341198122 0.328162625 8938 BAI1 associated protein 3 "GO:0000149,GO:0001956,GO:0005509,GO:0005515,GO:0005543,GO:0005829,GO:0005886,GO:0006887,GO:0007186,GO:0019905,GO:0031045,GO:0031901,GO:0031902,GO:0032228,GO:0032588,GO:0035774,GO:0042147,GO:0055038,GO:0098793,GO:1905413,GO:1990502" "SNARE binding|positive regulation of neurotransmitter secretion|calcium ion binding|protein binding|phospholipid binding|cytosol|plasma membrane|exocytosis|G protein-coupled receptor signaling pathway|syntaxin binding|dense core granule|early endosome membrane|late endosome membrane|regulation of synaptic transmission, GABAergic|trans-Golgi network membrane|positive regulation of insulin secretion involved in cellular response to glucose stimulus|retrograde transport, endosome to Golgi|recycling endosome membrane|presynapse|regulation of dense core granule exocytosis|dense core granule maturation" hsa05202 Transcriptional misregulation in cancer BAK1 710.8598475 683.5519209 738.1677742 1.07990008 0.11089783 0.668007911 1 15.99294595 16.98178044 578 BCL2 antagonist/killer 1 "GO:0001782,GO:0001783,GO:0001836,GO:0001974,GO:0002262,GO:0002352,GO:0003674,GO:0005515,GO:0005739,GO:0005741,GO:0005783,GO:0005829,GO:0006915,GO:0007420,GO:0007568,GO:0008053,GO:0008283,GO:0008285,GO:0008630,GO:0008635,GO:0009620,GO:0010046,GO:0010225,GO:0010248,GO:0010332,GO:0010524,GO:0010629,GO:0014070,GO:0016032,GO:0031018,GO:0031072,GO:0031100,GO:0031307,GO:0031334,GO:0032469,GO:0032471,GO:0033137,GO:0034620,GO:0034644,GO:0035108,GO:0042493,GO:0042542,GO:0042802,GO:0042803,GO:0043065,GO:0044325,GO:0044346,GO:0044877,GO:0045471,GO:0045862,GO:0046872,GO:0046902,GO:0046930,GO:0046982,GO:0048597,GO:0051087,GO:0051400,GO:0051726,GO:0051881,GO:0060068,GO:0070059,GO:0070242,GO:0071260,GO:0090200,GO:0097136,GO:0097145,GO:0097190,GO:0097192,GO:0097202,GO:1900103,GO:1901030,GO:1902262,GO:1903896" B cell homeostasis|B cell apoptotic process|release of cytochrome c from mitochondria|blood vessel remodeling|myeloid cell homeostasis|B cell negative selection|molecular_function|protein binding|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|cytosol|apoptotic process|brain development|aging|mitochondrial fusion|cell population proliferation|negative regulation of cell population proliferation|intrinsic apoptotic signaling pathway in response to DNA damage|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|response to fungus|response to mycotoxin|response to UV-C|establishment or maintenance of transmembrane electrochemical gradient|response to gamma radiation|positive regulation of calcium ion transport into cytosol|negative regulation of gene expression|response to organic cyclic compound|viral process|endocrine pancreas development|heat shock protein binding|animal organ regeneration|integral component of mitochondrial outer membrane|positive regulation of protein-containing complex assembly|endoplasmic reticulum calcium ion homeostasis|negative regulation of endoplasmic reticulum calcium ion concentration|negative regulation of peptidyl-serine phosphorylation|cellular response to unfolded protein|cellular response to UV|limb morphogenesis|response to drug|response to hydrogen peroxide|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|ion channel binding|fibroblast apoptotic process|protein-containing complex binding|response to ethanol|positive regulation of proteolysis|metal ion binding|regulation of mitochondrial membrane permeability|pore complex|protein heterodimerization activity|post-embryonic camera-type eye morphogenesis|chaperone binding|BH domain binding|regulation of cell cycle|regulation of mitochondrial membrane potential|vagina development|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|thymocyte apoptotic process|cellular response to mechanical stimulus|positive regulation of release of cytochrome c from mitochondria|Bcl-2 family protein complex|BAK complex|apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|activation of cysteine-type endopeptidase activity|positive regulation of endoplasmic reticulum unfolded protein response|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|apoptotic process involved in blood vessel morphogenesis|positive regulation of IRE1-mediated unfolded protein response "hsa01524,hsa04141,hsa04210,hsa04215,hsa05022,hsa05130,hsa05132,hsa05160,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05202,hsa05203,hsa05206,hsa05210,hsa05212,hsa05213,hsa05214,hsa05216,hsa05217,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" Platinum drug resistance|Protein processing in endoplasmic reticulum|Apoptosis|Apoptosis - multiple species|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection|Hepatitis C|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|MicroRNAs in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Thyroid cancer|Basal cell carcinoma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer BAMBI 18.61359342 21.84869154 15.3784953 0.703863445 -0.506632533 0.594402889 1 0.689547316 0.477225522 25805 BMP and activin membrane bound inhibitor "GO:0005109,GO:0005114,GO:0005515,GO:0005737,GO:0005886,GO:0007179,GO:0008284,GO:0008360,GO:0010718,GO:0016021,GO:0016477,GO:0030512,GO:0030514,GO:0032092,GO:0045668,GO:0045893,GO:0090263" "frizzled binding|type II transforming growth factor beta receptor binding|protein binding|cytoplasm|plasma membrane|transforming growth factor beta receptor signaling pathway|positive regulation of cell population proliferation|regulation of cell shape|positive regulation of epithelial to mesenchymal transition|integral component of membrane|cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|positive regulation of protein binding|negative regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|positive regulation of canonical Wnt signaling pathway" "hsa04310,hsa04350" Wnt signaling pathway|TGF-beta signaling pathway BANF1 2245.668853 2067.302385 2424.035321 1.172559631 0.229661293 0.331477155 1 67.27324923 77.56191457 8815 BAF nuclear assembly factor 1 "GO:0000793,GO:0003677,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005829,GO:0007059,GO:0007084,GO:0008022,GO:0009615,GO:0015074,GO:0019899,GO:0030261,GO:0042802,GO:0042803,GO:0045071,GO:0047485,GO:0051169,GO:0075713,GO:0097726" condensed chromosome|DNA binding|protein binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|cytosol|chromosome segregation|mitotic nuclear envelope reassembly|protein C-terminus binding|response to virus|DNA integration|enzyme binding|chromosome condensation|identical protein binding|protein homodimerization activity|negative regulation of viral genome replication|protein N-terminus binding|nuclear transport|establishment of integrated proviral latency|LEM domain binding BANK1 37.95056901 37.45489978 38.44623824 1.026467524 0.037687984 1 1 0.569486941 0.574778033 55024 B cell scaffold protein with ankyrin repeats 1 "GO:0005102,GO:0009617,GO:0032715,GO:0042113,GO:0043410,GO:0045947,GO:0050731,GO:0050869,GO:0051898,GO:1990782" signaling receptor binding|response to bacterium|negative regulation of interleukin-6 production|B cell activation|positive regulation of MAPK cascade|negative regulation of translational initiation|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of B cell activation|negative regulation of protein kinase B signaling|protein tyrosine kinase binding BANP 236.8740246 225.7698125 247.9782366 1.098367553 0.135360913 0.700615452 1 1.861699621 2.01061299 54971 BTG3 associated nuclear protein "GO:0003677,GO:0005515,GO:0005654,GO:0006325,GO:0007049,GO:0007275,GO:0016604,GO:0034504,GO:0042177,GO:0045893,GO:1901796" "DNA binding|protein binding|nucleoplasm|chromatin organization|cell cycle|multicellular organism development|nuclear body|protein localization to nucleus|negative regulation of protein catabolic process|positive regulation of transcription, DNA-templated|regulation of signal transduction by p53 class mediator" BAP1 1713.819944 1692.753387 1734.886501 1.024890285 0.035469476 0.8836201 1 25.06635325 25.26037018 8314 BRCA1 associated protein 1 "GO:0001558,GO:0003682,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006464,GO:0006511,GO:0008233,GO:0008234,GO:0008285,GO:0010035,GO:0016579,GO:0018215,GO:0035517,GO:0035520,GO:0035522,GO:0045892,GO:0050727,GO:0051726,GO:0061519,GO:0071108,GO:1900015,GO:1903955" "regulation of cell growth|chromatin binding|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cellular protein modification process|ubiquitin-dependent protein catabolic process|peptidase activity|cysteine-type peptidase activity|negative regulation of cell population proliferation|response to inorganic substance|protein deubiquitination|protein phosphopantetheinylation|PR-DUB complex|monoubiquitinated protein deubiquitination|monoubiquitinated histone H2A deubiquitination|negative regulation of transcription, DNA-templated|regulation of inflammatory response|regulation of cell cycle|macrophage homeostasis|protein K48-linked deubiquitination|regulation of cytokine production involved in inflammatory response|positive regulation of protein targeting to mitochondrion" BARD1 812.855621 800.0782758 825.6329662 1.031940238 0.045359423 0.861349458 1 7.630219281 7.74217074 580 BRCA1 associated RING domain 1 "GO:0000151,GO:0000729,GO:0001894,GO:0003723,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006260,GO:0006303,GO:0006974,GO:0007050,GO:0016567,GO:0016579,GO:0016607,GO:0019900,GO:0031436,GO:0031441,GO:0036464,GO:0042325,GO:0042803,GO:0043065,GO:0043066,GO:0045732,GO:0046826,GO:0046872,GO:0046982,GO:0070531,GO:0085020,GO:1901796" ubiquitin ligase complex|DNA double-strand break processing|tissue homeostasis|RNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|DNA replication|double-strand break repair via nonhomologous end joining|cellular response to DNA damage stimulus|cell cycle arrest|protein ubiquitination|protein deubiquitination|nuclear speck|kinase binding|BRCA1-BARD1 complex|negative regulation of mRNA 3'-end processing|cytoplasmic ribonucleoprotein granule|regulation of phosphorylation|protein homodimerization activity|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of protein catabolic process|negative regulation of protein export from nucleus|metal ion binding|protein heterodimerization activity|BRCA1-A complex|protein K6-linked ubiquitination|regulation of signal transduction by p53 class mediator hsa03440 Homologous recombination BASP1 3727.22425 3226.32345 4228.12505 1.310508731 0.390126965 0.100933925 1 91.48934793 117.8912655 10409 brain abundant membrane attached signal protein 1 "GO:0000785,GO:0000976,GO:0003714,GO:0005515,GO:0005634,GO:0005737,GO:0005856,GO:0005886,GO:0007356,GO:0008180,GO:0008406,GO:0016363,GO:0016605,GO:0016607,GO:0019904,GO:0021762,GO:0030054,GO:0030426,GO:0031982,GO:0045892,GO:0060231,GO:0060421,GO:0060539,GO:0070062,GO:0072075,GO:0072112,GO:2001076" "chromatin|transcription regulatory region sequence-specific DNA binding|transcription corepressor activity|protein binding|nucleus|cytoplasm|cytoskeleton|plasma membrane|thorax and anterior abdomen determination|COP9 signalosome|gonad development|nuclear matrix|PML body|nuclear speck|protein domain specific binding|substantia nigra development|cell junction|growth cone|vesicle|negative regulation of transcription, DNA-templated|mesenchymal to epithelial transition|positive regulation of heart growth|diaphragm development|extracellular exosome|metanephric mesenchyme development|glomerular visceral epithelial cell differentiation|positive regulation of metanephric ureteric bud development" BATF2 28.25975152 35.37407201 21.14543103 0.597766382 -0.742346333 0.324718831 1 0.831651634 0.488814534 116071 basic leucine zipper ATF-like transcription factor 2 "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0042832,GO:0043011" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|defense response to protozoan|myeloid dendritic cell differentiation" hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer BATF3 67.13184752 71.7885579 62.47513714 0.870265944 -0.200471754 0.730245617 1 3.033431032 2.595716709 55509 basic leucine zipper ATF-like transcription factor 3 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0009615,GO:0043011,GO:0097028,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|response to virus|myeloid dendritic cell differentiation|dendritic cell differentiation|sequence-specific double-stranded DNA binding" hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer TF_bZIP BAX 894.0236095 824.0077951 964.0394239 1.169939689 0.226434161 0.363053865 1 49.18991226 56.58622224 581 "BCL2 associated X, apoptosis regulator" "GO:0001541,GO:0001764,GO:0001777,GO:0001782,GO:0001783,GO:0001822,GO:0001836,GO:0001844,GO:0001974,GO:0002262,GO:0002352,GO:0002358,GO:0002904,GO:0005515,GO:0005634,GO:0005635,GO:0005737,GO:0005739,GO:0005741,GO:0005757,GO:0005783,GO:0005789,GO:0005829,GO:0006367,GO:0006687,GO:0006808,GO:0006915,GO:0006919,GO:0006977,GO:0007281,GO:0008053,GO:0008289,GO:0008625,GO:0008630,GO:0008635,GO:0008637,GO:0009566,GO:0009636,GO:0009651,GO:0010248,GO:0010332,GO:0010917,GO:0015267,GO:0016020,GO:0016032,GO:0021854,GO:0021987,GO:0030544,GO:0031334,GO:0032091,GO:0032469,GO:0032471,GO:0032976,GO:0033137,GO:0033599,GO:0034620,GO:0034644,GO:0035234,GO:0042475,GO:0042802,GO:0042803,GO:0042981,GO:0043065,GO:0043524,GO:0043525,GO:0043653,GO:0045136,GO:0046666,GO:0046930,GO:0046982,GO:0048087,GO:0048147,GO:0048515,GO:0048597,GO:0048678,GO:0048873,GO:0051087,GO:0051281,GO:0051402,GO:0051434,GO:0051881,GO:0060011,GO:0060041,GO:0060058,GO:0060068,GO:0070059,GO:0070062,GO:0070242,GO:0070584,GO:0071944,GO:0072332,GO:0090200,GO:0097136,GO:0097144,GO:0097145,GO:0097190,GO:0097191,GO:0097192,GO:0097193,GO:0097296,GO:0098586,GO:1900103,GO:1901030,GO:1902262,GO:1902263,GO:1902445,GO:1902512,GO:1903896,GO:1990117,GO:2001234,GO:2001244" "ovarian follicle development|neuron migration|T cell homeostatic proliferation|B cell homeostasis|B cell apoptotic process|kidney development|release of cytochrome c from mitochondria|protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|blood vessel remodeling|myeloid cell homeostasis|B cell negative selection|B cell homeostatic proliferation|positive regulation of B cell apoptotic process|protein binding|nucleus|nuclear envelope|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial permeability transition pore complex|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|transcription initiation from RNA polymerase II promoter|glycosphingolipid metabolic process|regulation of nitrogen utilization|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|germ cell development|mitochondrial fusion|lipid binding|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|apoptotic mitochondrial changes|fertilization|response to toxic substance|response to salt stress|establishment or maintenance of transmembrane electrochemical gradient|response to gamma radiation|negative regulation of mitochondrial membrane potential|channel activity|membrane|viral process|hypothalamus development|cerebral cortex development|Hsp70 protein binding|positive regulation of protein-containing complex assembly|negative regulation of protein binding|endoplasmic reticulum calcium ion homeostasis|negative regulation of endoplasmic reticulum calcium ion concentration|release of matrix enzymes from mitochondria|negative regulation of peptidyl-serine phosphorylation|regulation of mammary gland epithelial cell proliferation|cellular response to unfolded protein|cellular response to UV|ectopic germ cell programmed cell death|odontogenesis of dentin-containing tooth|identical protein binding|protein homodimerization activity|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of neuron apoptotic process|positive regulation of neuron apoptotic process|mitochondrial fragmentation involved in apoptotic process|development of secondary sexual characteristics|retinal cell programmed cell death|pore complex|protein heterodimerization activity|positive regulation of developmental pigmentation|negative regulation of fibroblast proliferation|spermatid differentiation|post-embryonic camera-type eye morphogenesis|response to axon injury|homeostasis of number of cells within a tissue|chaperone binding|positive regulation of release of sequestered calcium ion into cytosol|neuron apoptotic process|BH3 domain binding|regulation of mitochondrial membrane potential|Sertoli cell proliferation|retina development in camera-type eye|positive regulation of apoptotic process involved in mammary gland involution|vagina development|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|extracellular exosome|thymocyte apoptotic process|mitochondrion morphogenesis|cell periphery|intrinsic apoptotic signaling pathway by p53 class mediator|positive regulation of release of cytochrome c from mitochondria|Bcl-2 family protein complex|BAX complex|BAK complex|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|intrinsic apoptotic signaling pathway|activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|cellular response to virus|positive regulation of endoplasmic reticulum unfolded protein response|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|apoptotic process involved in blood vessel morphogenesis|apoptotic process involved in embryonic digit morphogenesis|regulation of mitochondrial membrane permeability involved in programmed necrotic cell death|positive regulation of apoptotic DNA fragmentation|positive regulation of IRE1-mediated unfolded protein response|B cell receptor apoptotic signaling pathway|negative regulation of apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway" "hsa01521,hsa01522,hsa01524,hsa04071,hsa04115,hsa04141,hsa04210,hsa04211,hsa04215,hsa04217,hsa04722,hsa04932,hsa04933,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05131,hsa05132,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05202,hsa05203,hsa05210,hsa05212,hsa05213,hsa05214,hsa05216,hsa05217,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|Sphingolipid signaling pathway|p53 signaling pathway|Protein processing in endoplasmic reticulum|Apoptosis|Longevity regulating pathway|Apoptosis - multiple species|Necroptosis|Neurotrophin signaling pathway|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Thyroid cancer|Basal cell carcinoma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer BAZ1A 1935.215479 2067.302385 1803.128573 0.87221327 -0.197247155 0.405094811 1 18.7377936 16.06986837 11177 bromodomain adjacent to zinc finger domain 1A "GO:0000228,GO:0004402,GO:0005515,GO:0006261,GO:0006338,GO:0006357,GO:0008623,GO:0016573,GO:0016590,GO:0046872" nuclear chromosome|histone acetyltransferase activity|protein binding|DNA-dependent DNA replication|chromatin remodeling|regulation of transcription by RNA polymerase II|CHRAC|histone acetylation|ACF complex|metal ion binding BAZ1B 4307.729309 4600.710189 4014.748428 0.872636672 -0.196546992 0.410362552 1 37.19046456 31.91069345 9031 bromodomain adjacent to zinc finger domain 1B "GO:0000793,GO:0004713,GO:0004715,GO:0005515,GO:0005524,GO:0005654,GO:0005721,GO:0006333,GO:0006338,GO:0006357,GO:0006974,GO:0008270,GO:0016572,GO:0016604,GO:0018108,GO:0035173,GO:0042393,GO:0043596,GO:0045815" "condensed chromosome|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|nucleoplasm|pericentric heterochromatin|chromatin assembly or disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|zinc ion binding|histone phosphorylation|nuclear body|peptidyl-tyrosine phosphorylation|histone kinase activity|histone binding|nuclear replication fork|positive regulation of gene expression, epigenetic" BAZ2A 4001.524336 4194.948775 3808.099898 0.907782217 -0.139581869 0.558107954 1 23.66561376 21.12373067 11176 bromodomain adjacent to zinc finger domain 2A "GO:0000183,GO:0001164,GO:0001188,GO:0003723,GO:0005515,GO:0005677,GO:0005730,GO:0005829,GO:0006306,GO:0006338,GO:0006351,GO:0006355,GO:0016575,GO:0016607,GO:0016922,GO:0033553,GO:0042393,GO:0046872,GO:0070577" "rDNA heterochromatin assembly|RNA polymerase I core promoter sequence-specific DNA binding|RNA polymerase I preinitiation complex assembly|RNA binding|protein binding|chromatin silencing complex|nucleolus|cytosol|DNA methylation|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|histone deacetylation|nuclear speck|nuclear receptor binding|rDNA heterochromatin|histone binding|metal ion binding|lysine-acetylated histone binding" BAZ2B 607.476446 631.5312268 583.4216653 0.923820772 -0.11431511 0.667058442 1 3.040748905 2.762100399 29994 bromodomain adjacent to zinc finger domain 2B "GO:0003677,GO:0005515,GO:0005634,GO:0006338,GO:0006357,GO:0046872" DNA binding|protein binding|nucleus|chromatin remodeling|regulation of transcription by RNA polymerase II|metal ion binding BBC3 147.4273844 173.7491184 121.1056505 0.697014474 -0.520739479 0.202512052 1 3.902639357 2.674677322 27113 BCL2 binding component 3 "GO:0001836,GO:0005515,GO:0005739,GO:0005764,GO:0006915,GO:0006919,GO:0051117,GO:0070059,GO:0090200,GO:0097194,GO:1900740,GO:2001244" release of cytochrome c from mitochondria|protein binding|mitochondrion|lysosome|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|ATPase binding|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|positive regulation of release of cytochrome c from mitochondria|execution phase of apoptosis|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway "hsa01524,hsa04115,hsa04210,hsa04215,hsa04390,hsa05016,hsa05162,hsa05200,hsa05210" Platinum drug resistance|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Hippo signaling pathway|Huntington disease|Measles|Pathways in cancer|Colorectal cancer BBIP1 297.9715945 265.3055401 330.6376489 1.246252335 0.317596208 0.315517521 1 5.355094199 6.562121669 92482 BBSome interacting protein 1 "GO:0005515,GO:0005737,GO:0005829,GO:0015031,GO:0034464,GO:0060271,GO:0097500" protein binding|cytoplasm|cytosol|protein transport|BBSome|cilium assembly|receptor localization to non-motile cilium BBLN 452.4636096 498.3582498 406.5689694 0.815816673 -0.293683103 0.295011225 1 30.25763805 24.27162083 79095 bublin coiled coil protein BBOF1 54.15624212 71.7885579 36.52392633 0.50877086 -0.974912053 0.094209884 1 0.826050753 0.413237893 80127 basal body orientation factor 1 "GO:0005737,GO:0036064,GO:0044458" cytoplasm|ciliary basal body|motile cilium assembly BBS1 334.4156485 364.1448589 304.686438 0.83671767 -0.257187192 0.400510994 1 5.770113376 4.74716652 582 Bardet-Biedl syndrome 1 "GO:0001103,GO:0005113,GO:0005119,GO:0005515,GO:0005813,GO:0005829,GO:0005930,GO:0007601,GO:0007608,GO:0034464,GO:0036064,GO:0043001,GO:0045494,GO:0050896,GO:0060170,GO:0060271,GO:0061512,GO:1905515" RNA polymerase II repressing transcription factor binding|patched binding|smoothened binding|protein binding|centrosome|cytosol|axoneme|visual perception|sensory perception of smell|BBSome|ciliary basal body|Golgi to plasma membrane protein transport|photoreceptor cell maintenance|response to stimulus|ciliary membrane|cilium assembly|protein localization to cilium|non-motile cilium assembly BBS10 648.1670583 627.3695712 668.9645454 1.066300592 0.092614194 0.725470042 1 9.383845561 9.838563218 79738 Bardet-Biedl syndrome 10 "GO:0001103,GO:0005515,GO:0005524,GO:0005929,GO:0007601,GO:0043254,GO:0045494,GO:0050896,GO:0051131,GO:1905515" RNA polymerase II repressing transcription factor binding|protein binding|ATP binding|cilium|visual perception|regulation of protein-containing complex assembly|photoreceptor cell maintenance|response to stimulus|chaperone-mediated protein complex assembly|non-motile cilium assembly BBS12 137.028276 140.4558742 133.6006779 0.951193239 -0.072189634 0.880346471 1 2.099683993 1.963784694 166379 Bardet-Biedl syndrome 12 "GO:0005515,GO:0005524,GO:0005929,GO:0042073,GO:0042755,GO:0045494,GO:0045599,GO:0051131" protein binding|ATP binding|cilium|intraciliary transport|eating behavior|photoreceptor cell maintenance|negative regulation of fat cell differentiation|chaperone-mediated protein complex assembly BBS2 1770.31994 1712.521251 1828.118628 1.067501281 0.094237801 0.692665803 1 31.34228795 32.89805934 583 Bardet-Biedl syndrome 2 "GO:0001103,GO:0005515,GO:0005829,GO:0005902,GO:0007288,GO:0007601,GO:0008104,GO:0010629,GO:0014824,GO:0016020,GO:0021756,GO:0021766,GO:0021987,GO:0030534,GO:0031514,GO:0032402,GO:0032420,GO:0033365,GO:0034464,GO:0036064,GO:0038108,GO:0040015,GO:0040018,GO:0042311,GO:0043001,GO:0043005,GO:0045444,GO:0045494,GO:0048854,GO:0051216,GO:0060170,GO:0060271,GO:0060296,GO:1905515" RNA polymerase II repressing transcription factor binding|protein binding|cytosol|microvillus|sperm axoneme assembly|visual perception|protein localization|negative regulation of gene expression|artery smooth muscle contraction|membrane|striatum development|hippocampus development|cerebral cortex development|adult behavior|motile cilium|melanosome transport|stereocilium|protein localization to organelle|BBSome|ciliary basal body|negative regulation of appetite by leptin-mediated signaling pathway|negative regulation of multicellular organism growth|positive regulation of multicellular organism growth|vasodilation|Golgi to plasma membrane protein transport|neuron projection|fat cell differentiation|photoreceptor cell maintenance|brain morphogenesis|cartilage development|ciliary membrane|cilium assembly|regulation of cilium beat frequency involved in ciliary motility|non-motile cilium assembly BBS4 380.4221866 385.9935505 374.8508228 0.971132348 -0.042260173 0.89441675 1 7.380783362 7.047775428 585 Bardet-Biedl syndrome 4 "GO:0000226,GO:0000242,GO:0000281,GO:0001103,GO:0001843,GO:0001895,GO:0001947,GO:0005515,GO:0005634,GO:0005813,GO:0005814,GO:0005829,GO:0005929,GO:0007098,GO:0007286,GO:0007601,GO:0007608,GO:0015031,GO:0016358,GO:0019216,GO:0021756,GO:0021766,GO:0021987,GO:0030534,GO:0030674,GO:0031514,GO:0032402,GO:0032465,GO:0033365,GO:0034451,GO:0034452,GO:0034454,GO:0034464,GO:0035869,GO:0036064,GO:0038108,GO:0043014,GO:0045444,GO:0045494,GO:0045724,GO:0046548,GO:0046907,GO:0048487,GO:0048854,GO:0050893,GO:0051457,GO:0060170,GO:0060271,GO:0060296,GO:0061512,GO:0071539,GO:0097730,GO:1905515" microtubule cytoskeleton organization|pericentriolar material|mitotic cytokinesis|RNA polymerase II repressing transcription factor binding|neural tube closure|retina homeostasis|heart looping|protein binding|nucleus|centrosome|centriole|cytosol|cilium|centrosome cycle|spermatid development|visual perception|sensory perception of smell|protein transport|dendrite development|regulation of lipid metabolic process|striatum development|hippocampus development|cerebral cortex development|adult behavior|protein-macromolecule adaptor activity|motile cilium|melanosome transport|regulation of cytokinesis|protein localization to organelle|centriolar satellite|dynactin binding|microtubule anchoring at centrosome|BBSome|ciliary transition zone|ciliary basal body|negative regulation of appetite by leptin-mediated signaling pathway|alpha-tubulin binding|fat cell differentiation|photoreceptor cell maintenance|positive regulation of cilium assembly|retinal rod cell development|intracellular transport|beta-tubulin binding|brain morphogenesis|sensory processing|maintenance of protein location in nucleus|ciliary membrane|cilium assembly|regulation of cilium beat frequency involved in ciliary motility|protein localization to cilium|protein localization to centrosome|non-motile cilium|non-motile cilium assembly BBS5 169.9403219 159.183324 180.6973197 1.135152321 0.182885899 0.646018742 1 2.689243887 3.001618615 129880 Bardet-Biedl syndrome 5 "GO:0001103,GO:0001947,GO:0005515,GO:0005829,GO:0005930,GO:0007601,GO:0015031,GO:0032266,GO:0032402,GO:0034451,GO:0034464,GO:0036064,GO:0044458,GO:0046907,GO:0050896,GO:0060170,GO:0060271" RNA polymerase II repressing transcription factor binding|heart looping|protein binding|cytosol|axoneme|visual perception|protein transport|phosphatidylinositol-3-phosphate binding|melanosome transport|centriolar satellite|BBSome|ciliary basal body|motile cilium assembly|intracellular transport|response to stimulus|ciliary membrane|cilium assembly BBS7 607.76894 601.3592242 614.1786559 1.021317428 0.030431329 0.914154494 1 7.456653472 7.48817322 55212 Bardet-Biedl syndrome 7 "GO:0001103,GO:0001654,GO:0001750,GO:0001947,GO:0005515,GO:0005634,GO:0005813,GO:0005829,GO:0005930,GO:0006357,GO:0007224,GO:0007368,GO:0007420,GO:0007601,GO:0008104,GO:0015031,GO:0016020,GO:0032402,GO:0032436,GO:0034464,GO:0036064,GO:0043005,GO:0045444,GO:0046907,GO:0048546,GO:0051877,GO:0060170,GO:0060173,GO:0060271,GO:1903929,GO:1905515" RNA polymerase II repressing transcription factor binding|eye development|photoreceptor outer segment|heart looping|protein binding|nucleus|centrosome|cytosol|axoneme|regulation of transcription by RNA polymerase II|smoothened signaling pathway|determination of left/right symmetry|brain development|visual perception|protein localization|protein transport|membrane|melanosome transport|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|BBSome|ciliary basal body|neuron projection|fat cell differentiation|intracellular transport|digestive tract morphogenesis|pigment granule aggregation in cell center|ciliary membrane|limb development|cilium assembly|primary palate development|non-motile cilium assembly BBS9 375.9239921 318.3666481 433.4813362 1.361578981 0.445280671 0.130289168 1 1.966964908 2.633362391 27241 Bardet-Biedl syndrome 9 "GO:0000242,GO:0003674,GO:0005515,GO:0005829,GO:0005929,GO:0007601,GO:0015031,GO:0016020,GO:0034451,GO:0034464,GO:0035869,GO:0045444,GO:0050896,GO:0060170,GO:0060271,GO:0061512" pericentriolar material|molecular_function|protein binding|cytosol|cilium|visual perception|protein transport|membrane|centriolar satellite|BBSome|ciliary transition zone|fat cell differentiation|response to stimulus|ciliary membrane|cilium assembly|protein localization to cilium BBX 2737.284534 3000.553638 2474.015431 0.824519649 -0.278374221 0.239214784 1 15.31210871 12.41386996 56987 BBX high mobility group box domain containing "GO:0000785,GO:0000977,GO:0000981,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0060348,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|bone development|sequence-specific double-stranded DNA binding" BCAM 376.1416442 374.5489978 377.7342907 1.008504342 0.012217296 0.977049797 1 8.148793974 8.080575433 4059 basal cell adhesion molecule (Lutheran blood group) "GO:0004888,GO:0005055,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0007155,GO:0007160,GO:0007165,GO:0008022,GO:0009897,GO:0043236,GO:0062023,GO:0070062" transmembrane signaling receptor activity|laminin receptor activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|cell adhesion|cell-matrix adhesion|signal transduction|protein C-terminus binding|external side of plasma membrane|laminin binding|collagen-containing extracellular matrix|extracellular exosome BCAP29 7.32755656 3.121241648 11.53387147 3.695283087 1.88568489 0.182046907 1 0.034197276 0.124254007 55973 B cell receptor associated protein 29 "GO:0001649,GO:0005789,GO:0006886,GO:0006888,GO:0006915,GO:0016020,GO:0016021,GO:0070973" osteoblast differentiation|endoplasmic reticulum membrane|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|apoptotic process|membrane|integral component of membrane|protein localization to endoplasmic reticulum exit site BCAP31 5203.120924 4514.355837 5891.88601 1.305144349 0.384209378 0.110327094 1 118.2733795 151.7807632 10134 B cell receptor associated protein 31 "GO:0002474,GO:0005515,GO:0005739,GO:0005783,GO:0005789,GO:0005811,GO:0005829,GO:0005887,GO:0006626,GO:0006888,GO:0006915,GO:0007204,GO:0007283,GO:0016020,GO:0016032,GO:0030136,GO:0032471,GO:0032580,GO:0033116,GO:0034976,GO:0035584,GO:0042288,GO:0043280,GO:0044233,GO:0044877,GO:0051561,GO:0070973,GO:0071556,GO:0097038,GO:1903071,GO:1904154,GO:2001244" "antigen processing and presentation of peptide antigen via MHC class I|protein binding|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|cytosol|integral component of plasma membrane|protein targeting to mitochondrion|endoplasmic reticulum to Golgi vesicle-mediated transport|apoptotic process|positive regulation of cytosolic calcium ion concentration|spermatogenesis|membrane|viral process|clathrin-coated vesicle|negative regulation of endoplasmic reticulum calcium ion concentration|Golgi cisterna membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|response to endoplasmic reticulum stress|calcium-mediated signaling using intracellular calcium source|MHC class I protein binding|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|mitochondria-associated endoplasmic reticulum membrane|protein-containing complex binding|positive regulation of mitochondrial calcium ion concentration|protein localization to endoplasmic reticulum exit site|integral component of lumenal side of endoplasmic reticulum membrane|perinuclear endoplasmic reticulum|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|positive regulation of retrograde protein transport, ER to cytosol|positive regulation of intrinsic apoptotic signaling pathway" "hsa04141,hsa05165" Protein processing in endoplasmic reticulum|Human papillomavirus infection BCAR1 2203.823356 2154.697151 2252.949561 1.045599174 0.064329906 0.7870473 1 20.20953019 20.77746826 9564 "BCAR1 scaffold protein, Cas family member" "GO:0001558,GO:0001726,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0007015,GO:0007155,GO:0007169,GO:0007173,GO:0007186,GO:0007229,GO:0008286,GO:0010595,GO:0015629,GO:0016477,GO:0017124,GO:0019901,GO:0030027,GO:0030335,GO:0030424,GO:0035729,GO:0042981,GO:0048008,GO:0048010,GO:0048011,GO:0048012,GO:0050851,GO:0050852,GO:0050853,GO:0051301,GO:0060326,GO:0086100,GO:0090527" regulation of cell growth|ruffle|protein binding|cytoplasm|cytosol|plasma membrane|focal adhesion|actin filament organization|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|epidermal growth factor receptor signaling pathway|G protein-coupled receptor signaling pathway|integrin-mediated signaling pathway|insulin receptor signaling pathway|positive regulation of endothelial cell migration|actin cytoskeleton|cell migration|SH3 domain binding|protein kinase binding|lamellipodium|positive regulation of cell migration|axon|cellular response to hepatocyte growth factor stimulus|regulation of apoptotic process|platelet-derived growth factor receptor signaling pathway|vascular endothelial growth factor receptor signaling pathway|neurotrophin TRK receptor signaling pathway|hepatocyte growth factor receptor signaling pathway|antigen receptor-mediated signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|cell division|cell chemotaxis|endothelin receptor signaling pathway|actin filament reorganization "hsa04015,hsa04062,hsa04510,hsa04670,hsa04810,hsa04935,hsa05100,hsa05131,hsa05135,hsa05163" "Rap1 signaling pathway|Chemokine signaling pathway|Focal adhesion|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Growth hormone synthesis, secretion and action|Bacterial invasion of epithelial cells|Shigellosis|Yersinia infection|Human cytomegalovirus infection" BCAR3 2410.549301 2459.538419 2361.560184 0.960163975 -0.058647288 0.80545376 1 27.69804705 26.14964121 8412 "BCAR3 adaptor protein, NSP family member" "GO:0001784,GO:0002089,GO:0005085,GO:0005515,GO:0005737,GO:0005925,GO:0007165,GO:0007264,GO:0008286,GO:0016020,GO:0019900,GO:0033138,GO:0042493,GO:0043410,GO:0043547,GO:0045740,GO:0045742,GO:0086100" phosphotyrosine residue binding|lens morphogenesis in camera-type eye|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|focal adhesion|signal transduction|small GTPase mediated signal transduction|insulin receptor signaling pathway|membrane|kinase binding|positive regulation of peptidyl-serine phosphorylation|response to drug|positive regulation of MAPK cascade|positive regulation of GTPase activity|positive regulation of DNA replication|positive regulation of epidermal growth factor receptor signaling pathway|endothelin receptor signaling pathway BCAS1 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.048535819 0.029392058 8537 brain enriched myelin associated protein 1 "GO:0005737,GO:0014069,GO:0042552,GO:0070062" cytoplasm|postsynaptic density|myelination|extracellular exosome BCAS2 729.2803266 687.7135764 770.8470767 1.120883902 0.164636855 0.520274901 1 28.78588989 31.72571877 10286 BCAS2 pre-mRNA processing factor "GO:0000375,GO:0000398,GO:0000974,GO:0005515,GO:0005634,GO:0005654,GO:0005662,GO:0005681,GO:0005730,GO:0005813,GO:0008380,GO:0016607,GO:0071007,GO:0071013" "RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|Prp19 complex|protein binding|nucleus|nucleoplasm|DNA replication factor A complex|spliceosomal complex|nucleolus|centrosome|RNA splicing|nuclear speck|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome BCAS3 868.493226 872.9072475 864.0792044 0.98988662 -0.014664805 0.958132269 1 7.505309403 7.305084317 54828 BCAS3 microtubule associated cell migration factor "GO:0001525,GO:0003682,GO:0005515,GO:0005634,GO:0005737,GO:0005881,GO:0007030,GO:0008134,GO:0010595,GO:0010698,GO:0031023,GO:0031252,GO:0034260,GO:0035035,GO:0035148,GO:0035257,GO:0035327,GO:0042393,GO:0042594,GO:0043085,GO:0043547,GO:0045111,GO:0045944,GO:0048487,GO:0051491,GO:0051895,GO:0071391,GO:0090316,GO:0090630,GO:2000114,GO:2000251" angiogenesis|chromatin binding|protein binding|nucleus|cytoplasm|cytoplasmic microtubule|Golgi organization|transcription factor binding|positive regulation of endothelial cell migration|acetyltransferase activator activity|microtubule organizing center organization|cell leading edge|negative regulation of GTPase activity|histone acetyltransferase binding|tube formation|nuclear hormone receptor binding|transcriptionally active chromatin|histone binding|response to starvation|positive regulation of catalytic activity|positive regulation of GTPase activity|intermediate filament cytoskeleton|positive regulation of transcription by RNA polymerase II|beta-tubulin binding|positive regulation of filopodium assembly|negative regulation of focal adhesion assembly|cellular response to estrogen stimulus|positive regulation of intracellular protein transport|activation of GTPase activity|regulation of establishment of cell polarity|positive regulation of actin cytoskeleton reorganization BCAS4 547.563329 534.7727357 560.3539223 1.047835622 0.067412414 0.807276675 1 8.28923556 8.540411933 55653 breast carcinoma amplified sequence 4 GO:0031083 BLOC-1 complex BCAT1 3996.801616 4386.384929 3607.218303 0.82236702 -0.282145687 0.236146514 1 18.52297055 14.97778182 586 branched chain amino acid transaminase 1 "GO:0000082,GO:0004084,GO:0005739,GO:0005829,GO:0009082,GO:0009083,GO:0009098,GO:0009099,GO:0042802,GO:0052654,GO:0052655,GO:0052656" G1/S transition of mitotic cell cycle|branched-chain-amino-acid transaminase activity|mitochondrion|cytosol|branched-chain amino acid biosynthetic process|branched-chain amino acid catabolic process|leucine biosynthetic process|valine biosynthetic process|identical protein binding|L-leucine transaminase activity|L-valine transaminase activity|L-isoleucine transaminase activity "hsa00270,hsa00280,hsa00290,hsa00770" "Cysteine and methionine metabolism|Valine, leucine and isoleucine degradation|Valine, leucine and isoleucine biosynthesis|Pantothenate and CoA biosynthesis" BCAT2 307.7114874 344.3769952 271.0459796 0.787061806 -0.345451164 0.269264839 1 8.376831036 6.482757432 587 branched chain amino acid transaminase 2 "GO:0004084,GO:0005515,GO:0005739,GO:0005759,GO:0009082,GO:0009083,GO:0009098,GO:0009099,GO:0052654,GO:0052655,GO:0052656" branched-chain-amino-acid transaminase activity|protein binding|mitochondrion|mitochondrial matrix|branched-chain amino acid biosynthetic process|branched-chain amino acid catabolic process|leucine biosynthetic process|valine biosynthetic process|L-leucine transaminase activity|L-valine transaminase activity|L-isoleucine transaminase activity "hsa00270,hsa00280,hsa00290,hsa00770" "Cysteine and methionine metabolism|Valine, leucine and isoleucine degradation|Valine, leucine and isoleucine biosynthesis|Pantothenate and CoA biosynthesis" BCCIP 901.2719081 825.0482089 977.4956072 1.184773928 0.244611798 0.325199636 1 13.13191367 15.29800104 56647 BRCA2 and CDKN1A interacting protein "GO:0000079,GO:0000226,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0006281,GO:0007052,GO:0019207,GO:0019908,GO:0034453,GO:0061101,GO:0090307,GO:0097431" regulation of cyclin-dependent protein serine/threonine kinase activity|microtubule cytoskeleton organization|RNA binding|protein binding|nucleus|nucleoplasm|centrosome|centriole|cytosol|DNA repair|mitotic spindle organization|kinase regulator activity|nuclear cyclin-dependent protein kinase holoenzyme complex|microtubule anchoring|neuroendocrine cell differentiation|mitotic spindle assembly|mitotic spindle pole BCDIN3D 73.77565087 82.19269673 65.35860501 0.7951875 -0.330633017 0.536843374 1 1.359725096 1.063143373 144233 BCDIN3 domain containing RNA methyltransferase "GO:0001510,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0008171,GO:0008173,GO:0008175,GO:0010586,GO:0030488,GO:0061715,GO:2000632" RNA methylation|protein binding|nucleoplasm|cytoplasm|cytosol|O-methyltransferase activity|RNA methyltransferase activity|tRNA methyltransferase activity|miRNA metabolic process|tRNA methylation|miRNA 2'-O-methylation|negative regulation of pre-miRNA processing BCHE 43.15263842 47.8590386 38.44623824 0.80332241 -0.315948971 0.639091649 1 1.062016187 0.838865237 590 butyrylcholinesterase "GO:0001540,GO:0003824,GO:0003990,GO:0004104,GO:0005515,GO:0005576,GO:0005641,GO:0005788,GO:0007612,GO:0008285,GO:0014016,GO:0016020,GO:0019695,GO:0019899,GO:0033265,GO:0042493,GO:0042802,GO:0043279,GO:0050783,GO:0050805,GO:0051384,GO:0051593,GO:0072562" amyloid-beta binding|catalytic activity|acetylcholinesterase activity|cholinesterase activity|protein binding|extracellular region|nuclear envelope lumen|endoplasmic reticulum lumen|learning|negative regulation of cell population proliferation|neuroblast differentiation|membrane|choline metabolic process|enzyme binding|choline binding|response to drug|identical protein binding|response to alkaloid|cocaine metabolic process|negative regulation of synaptic transmission|response to glucocorticoid|response to folic acid|blood microparticle BCKDHA 286.5566099 268.4267817 304.686438 1.135082111 0.182796665 0.574035596 1 8.22356142 9.178218621 593 branched chain keto acid dehydrogenase E1 subunit alpha "GO:0003826,GO:0003863,GO:0005515,GO:0005739,GO:0005759,GO:0005947,GO:0009083,GO:0016831,GO:0046872,GO:0055114" alpha-ketoacid dehydrogenase activity|3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|protein binding|mitochondrion|mitochondrial matrix|mitochondrial alpha-ketoglutarate dehydrogenase complex|branched-chain amino acid catabolic process|carboxy-lyase activity|metal ion binding|oxidation-reduction process "hsa00280,hsa00640" "Valine, leucine and isoleucine degradation|Propanoate metabolism" BCKDHB 242.8787341 232.0122958 253.7451724 1.093671228 0.12917911 0.711587568 1 1.931077637 2.076623191 594 branched chain keto acid dehydrogenase E1 subunit beta "GO:0003826,GO:0003863,GO:0005515,GO:0005730,GO:0005739,GO:0005759,GO:0005947,GO:0007584,GO:0009083,GO:0055114" alpha-ketoacid dehydrogenase activity|3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|protein binding|nucleolus|mitochondrion|mitochondrial matrix|mitochondrial alpha-ketoglutarate dehydrogenase complex|response to nutrient|branched-chain amino acid catabolic process|oxidation-reduction process "hsa00280,hsa00640" "Valine, leucine and isoleucine degradation|Propanoate metabolism" BCKDK 1366.151287 1321.325631 1410.976943 1.067849522 0.094708361 0.694991114 1 31.62184773 33.20232369 10295 branched chain keto acid dehydrogenase kinase "GO:0004674,GO:0004740,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0005947,GO:0006468,GO:0009063,GO:0009083,GO:0010906,GO:0016301,GO:0016310,GO:0047323" protein serine/threonine kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|mitochondrial alpha-ketoglutarate dehydrogenase complex|protein phosphorylation|cellular amino acid catabolic process|branched-chain amino acid catabolic process|regulation of glucose metabolic process|kinase activity|phosphorylation|[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity BCL10 1276.645511 1217.284243 1336.006779 1.09753066 0.134261243 0.578968772 1 16.47583636 17.78014547 8915 BCL10 immune signaling adaptor "GO:0001772,GO:0001783,GO:0001843,GO:0002020,GO:0002096,GO:0002223,GO:0002224,GO:0002250,GO:0002906,GO:0003713,GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005829,GO:0005881,GO:0006968,GO:0007249,GO:0008022,GO:0008134,GO:0008219,GO:0009620,GO:0016064,GO:0016567,GO:0019209,GO:0019899,GO:0019900,GO:0019901,GO:0031398,GO:0031625,GO:0031663,GO:0032094,GO:0032449,GO:0032755,GO:0032757,GO:0032761,GO:0032765,GO:0032991,GO:0033674,GO:0038095,GO:0042327,GO:0042802,GO:0043065,GO:0043123,GO:0043280,GO:0043422,GO:0043621,GO:0044877,GO:0045087,GO:0045121,GO:0045893,GO:0048471,GO:0050700,GO:0050852,GO:0050856,GO:0050870,GO:0051059,GO:0051092,GO:0070231,GO:0071222,GO:0071260,GO:2001238" "immunological synapse|B cell apoptotic process|neural tube closure|protease binding|polkadots|stimulatory C-type lectin receptor signaling pathway|toll-like receptor signaling pathway|adaptive immune response|negative regulation of mature B cell apoptotic process|transcription coactivator activity|protein binding|nucleus|cytoplasm|lysosome|cytosol|cytoplasmic microtubule|cellular defense response|I-kappaB kinase/NF-kappaB signaling|protein C-terminus binding|transcription factor binding|cell death|response to fungus|immunoglobulin mediated immune response|protein ubiquitination|kinase activator activity|enzyme binding|kinase binding|protein kinase binding|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|lipopolysaccharide-mediated signaling pathway|response to food|CBM complex|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lymphotoxin A production|positive regulation of mast cell cytokine production|protein-containing complex|positive regulation of kinase activity|Fc-epsilon receptor signaling pathway|positive regulation of phosphorylation|identical protein binding|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein kinase B binding|protein self-association|protein-containing complex binding|innate immune response|membrane raft|positive regulation of transcription, DNA-templated|perinuclear region of cytoplasm|CARD domain binding|T cell receptor signaling pathway|regulation of T cell receptor signaling pathway|positive regulation of T cell activation|NF-kappaB binding|positive regulation of NF-kappaB transcription factor activity|T cell apoptotic process|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|positive regulation of extrinsic apoptotic signaling pathway" "hsa04064,hsa04625,hsa04660,hsa04662,hsa05131,hsa05152" NF-kappa B signaling pathway|C-type lectin receptor signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Shigellosis|Tuberculosis BCL2 236.8243348 249.6993318 223.9493377 0.896875999 -0.157019561 0.653345165 1 1.313423459 1.158266111 596 BCL2 apoptosis regulator "GO:0000209,GO:0001503,GO:0001541,GO:0001656,GO:0001658,GO:0001662,GO:0001782,GO:0001836,GO:0001952,GO:0002020,GO:0002320,GO:0002326,GO:0002931,GO:0003014,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005783,GO:0005789,GO:0005829,GO:0006470,GO:0006582,GO:0006808,GO:0006915,GO:0006959,GO:0006974,GO:0007015,GO:0007409,GO:0007565,GO:0007569,GO:0008284,GO:0008584,GO:0008625,GO:0008630,GO:0008631,GO:0009314,GO:0009636,GO:0009791,GO:0010039,GO:0010224,GO:0010332,GO:0010468,GO:0010507,GO:0010523,GO:0010559,GO:0014031,GO:0014042,GO:0014911,GO:0015267,GO:0016020,GO:0016248,GO:0018105,GO:0018107,GO:0019221,GO:0021747,GO:0022612,GO:0022898,GO:0030279,GO:0030307,GO:0030308,GO:0030318,GO:0030336,GO:0030890,GO:0031069,GO:0031103,GO:0031625,GO:0031647,GO:0031965,GO:0032469,GO:0032835,GO:0032848,GO:0032991,GO:0033033,GO:0033077,GO:0033138,GO:0033689,GO:0034097,GO:0035094,GO:0035265,GO:0040018,GO:0042100,GO:0042149,GO:0042493,GO:0042542,GO:0042802,GO:0042803,GO:0043029,GO:0043066,GO:0043085,GO:0043209,GO:0043375,GO:0043524,GO:0043565,GO:0043583,GO:0045069,GO:0045636,GO:0046671,GO:0046902,GO:0046930,GO:0046982,GO:0048041,GO:0048536,GO:0048538,GO:0048546,GO:0048599,GO:0048743,GO:0048753,GO:0048873,GO:0050853,GO:0051384,GO:0051402,GO:0051434,GO:0051607,GO:0051721,GO:0051881,GO:0051902,GO:0051924,GO:0055085,GO:0070059,GO:0070491,GO:0071456,GO:0072593,GO:0097192,GO:0098609,GO:1900740,GO:1902166,GO:2000134,GO:2000378,GO:2000811,GO:2001234,GO:2001240,GO:2001243,GO:2001244" "protein polyubiquitination|ossification|ovarian follicle development|metanephros development|branching involved in ureteric bud morphogenesis|behavioral fear response|B cell homeostasis|release of cytochrome c from mitochondria|regulation of cell-matrix adhesion|protease binding|lymphoid progenitor cell differentiation|B cell lineage commitment|response to ischemia|renal system process|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|protein dephosphorylation|melanin metabolic process|regulation of nitrogen utilization|apoptotic process|humoral immune response|cellular response to DNA damage stimulus|actin filament organization|axonogenesis|female pregnancy|cell aging|positive regulation of cell population proliferation|male gonad development|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|intrinsic apoptotic signaling pathway in response to oxidative stress|response to radiation|response to toxic substance|post-embryonic development|response to iron ion|response to UV-B|response to gamma radiation|regulation of gene expression|negative regulation of autophagy|negative regulation of calcium ion transport into cytosol|regulation of glycoprotein biosynthetic process|mesenchymal cell development|positive regulation of neuron maturation|positive regulation of smooth muscle cell migration|channel activity|membrane|channel inhibitor activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|cytokine-mediated signaling pathway|cochlear nucleus development|gland morphogenesis|regulation of transmembrane transporter activity|negative regulation of ossification|positive regulation of cell growth|negative regulation of cell growth|melanocyte differentiation|negative regulation of cell migration|positive regulation of B cell proliferation|hair follicle morphogenesis|axon regeneration|ubiquitin protein ligase binding|regulation of protein stability|nuclear membrane|endoplasmic reticulum calcium ion homeostasis|glomerulus development|negative regulation of cellular pH reduction|protein-containing complex|negative regulation of myeloid cell apoptotic process|T cell differentiation in thymus|positive regulation of peptidyl-serine phosphorylation|negative regulation of osteoblast proliferation|response to cytokine|response to nicotine|organ growth|positive regulation of multicellular organism growth|B cell proliferation|cellular response to glucose starvation|response to drug|response to hydrogen peroxide|identical protein binding|protein homodimerization activity|T cell homeostasis|negative regulation of apoptotic process|positive regulation of catalytic activity|myelin sheath|CD8-positive, alpha-beta T cell lineage commitment|negative regulation of neuron apoptotic process|sequence-specific DNA binding|ear development|regulation of viral genome replication|positive regulation of melanocyte differentiation|negative regulation of retinal cell programmed cell death|regulation of mitochondrial membrane permeability|pore complex|protein heterodimerization activity|focal adhesion assembly|spleen development|thymus development|digestive tract morphogenesis|oocyte development|positive regulation of skeletal muscle fiber development|pigment granule organization|homeostasis of number of cells within a tissue|B cell receptor signaling pathway|response to glucocorticoid|neuron apoptotic process|BH3 domain binding|defense response to virus|protein phosphatase 2A binding|regulation of mitochondrial membrane potential|negative regulation of mitochondrial depolarization|regulation of calcium ion transport|transmembrane transport|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|repressing transcription factor binding|cellular response to hypoxia|reactive oxygen species metabolic process|extrinsic apoptotic signaling pathway in absence of ligand|cell-cell adhesion|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of reactive oxygen species metabolic process|negative regulation of anoikis|negative regulation of apoptotic signaling pathway|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of intrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway" "hsa01521,hsa01522,hsa01524,hsa04064,hsa04066,hsa04071,hsa04115,hsa04140,hsa04141,hsa04151,hsa04210,hsa04215,hsa04217,hsa04261,hsa04340,hsa04510,hsa04621,hsa04630,hsa04722,hsa04725,hsa04915,hsa04928,hsa04933,hsa05014,hsa05022,hsa05131,hsa05132,hsa05145,hsa05152,hsa05161,hsa05162,hsa05168,hsa05169,hsa05170,hsa05200,hsa05206,hsa05210,hsa05215,hsa05222,hsa05226,hsa05418" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|NF-kappa B signaling pathway|HIF-1 signaling pathway|Sphingolipid signaling pathway|p53 signaling pathway|Autophagy - animal|Protein processing in endoplasmic reticulum|PI3K-Akt signaling pathway|Apoptosis|Apoptosis - multiple species|Necroptosis|Adrenergic signaling in cardiomyocytes|Hedgehog signaling pathway|Focal adhesion|NOD-like receptor signaling pathway|JAK-STAT signaling pathway|Neurotrophin signaling pathway|Cholinergic synapse|Estrogen signaling pathway|Parathyroid hormone synthesis, secretion and action|AGE-RAGE signaling pathway in diabetic complications|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Shigellosis|Salmonella infection|Toxoplasmosis|Tuberculosis|Hepatitis B|Measles|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|MicroRNAs in cancer|Colorectal cancer|Prostate cancer|Small cell lung cancer|Gastric cancer|Fluid shear stress and atherosclerosis" BCL2A1 343.2352432 242.4164347 444.0540517 1.831781959 0.873247787 0.003984221 0.389173037 15.47526265 27.87295315 597 BCL2 related protein A1 "GO:0005515,GO:0005741,GO:0007568,GO:0008630,GO:0021987,GO:0042803,GO:0043066,GO:0044877,GO:0046982,GO:0051400,GO:0097192" protein binding|mitochondrial outer membrane|aging|intrinsic apoptotic signaling pathway in response to DNA damage|cerebral cortex development|protein homodimerization activity|negative regulation of apoptotic process|protein-containing complex binding|protein heterodimerization activity|BH domain binding|extrinsic apoptotic signaling pathway in absence of ligand "hsa04064,hsa04210,hsa05202,hsa05221" NF-kappa B signaling pathway|Apoptosis|Transcriptional misregulation in cancer|Acute myeloid leukemia BCL2L1 5247.145399 4585.103981 5909.186817 1.288779239 0.366005159 0.128348276 1 83.34420041 105.6148762 598 BCL2 like 1 "GO:0001836,GO:0005515,GO:0005737,GO:0005739,GO:0005741,GO:0005743,GO:0005759,GO:0005813,GO:0005829,GO:0006897,GO:0007093,GO:0008630,GO:0008637,GO:0016021,GO:0019050,GO:0019221,GO:0019901,GO:0030672,GO:0031965,GO:0032465,GO:0034097,GO:0042802,GO:0042803,GO:0043066,GO:0046902,GO:0046982,GO:0051434,GO:0051607,GO:0051881,GO:0090201,GO:0097136,GO:0097192,GO:1900118,GO:1902042,GO:1902230,GO:1902236,GO:1903077,GO:2001240,GO:2001243,GO:2001244" release of cytochrome c from mitochondria|protein binding|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial matrix|centrosome|cytosol|endocytosis|mitotic cell cycle checkpoint|intrinsic apoptotic signaling pathway in response to DNA damage|apoptotic mitochondrial changes|integral component of membrane|suppression by virus of host apoptotic process|cytokine-mediated signaling pathway|protein kinase binding|synaptic vesicle membrane|nuclear membrane|regulation of cytokinesis|response to cytokine|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|regulation of mitochondrial membrane permeability|protein heterodimerization activity|BH3 domain binding|defense response to virus|regulation of mitochondrial membrane potential|negative regulation of release of cytochrome c from mitochondria|Bcl-2 family protein complex|extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of execution phase of apoptosis|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|negative regulation of protein localization to plasma membrane|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of intrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway "hsa01521,hsa01524,hsa04014,hsa04064,hsa04115,hsa04137,hsa04140,hsa04151,hsa04210,hsa04215,hsa04621,hsa04630,hsa05012,hsa05014,hsa05022,hsa05131,hsa05145,hsa05162,hsa05166,hsa05168,hsa05170,hsa05200,hsa05202,hsa05212,hsa05220,hsa05222,hsa05225" EGFR tyrosine kinase inhibitor resistance|Platinum drug resistance|Ras signaling pathway|NF-kappa B signaling pathway|p53 signaling pathway|Mitophagy - animal|Autophagy - animal|PI3K-Akt signaling pathway|Apoptosis|Apoptosis - multiple species|NOD-like receptor signaling pathway|JAK-STAT signaling pathway|Parkinson disease|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Shigellosis|Toxoplasmosis|Measles|Human T-cell leukemia virus 1 infection|Herpes simplex virus 1 infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Pancreatic cancer|Chronic myeloid leukemia|Small cell lung cancer|Hepatocellular carcinoma BCL2L11 193.0225417 222.6485709 163.3965125 0.733876314 -0.44639116 0.226216453 1 1.543161691 1.11353913 10018 BCL2 like 11 "GO:0001701,GO:0001782,GO:0001783,GO:0001822,GO:0001844,GO:0002262,GO:0005515,GO:0005739,GO:0005741,GO:0005829,GO:0006915,GO:0007127,GO:0007160,GO:0007283,GO:0007420,GO:0008017,GO:0008584,GO:0008630,GO:0012505,GO:0019898,GO:0019901,GO:0030879,GO:0031334,GO:0034263,GO:0034976,GO:0035148,GO:0042475,GO:0042981,GO:0043029,GO:0043065,GO:0043280,GO:0043525,GO:0043583,GO:0045787,GO:0046620,GO:0048066,GO:0048070,GO:0048536,GO:0048538,GO:0048563,GO:0060139,GO:0070242,GO:0071385,GO:0071392,GO:0090200,GO:0097136,GO:0097192,GO:1902237,GO:1902263,GO:1903896,GO:1904646,GO:2000271,GO:2001244" in utero embryonic development|B cell homeostasis|B cell apoptotic process|kidney development|protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|myeloid cell homeostasis|protein binding|mitochondrion|mitochondrial outer membrane|cytosol|apoptotic process|meiosis I|cell-matrix adhesion|spermatogenesis|brain development|microtubule binding|male gonad development|intrinsic apoptotic signaling pathway in response to DNA damage|endomembrane system|extrinsic component of membrane|protein kinase binding|mammary gland development|positive regulation of protein-containing complex assembly|positive regulation of autophagy in response to ER overload|response to endoplasmic reticulum stress|tube formation|odontogenesis of dentin-containing tooth|regulation of apoptotic process|T cell homeostasis|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of neuron apoptotic process|ear development|positive regulation of cell cycle|regulation of organ growth|developmental pigmentation|regulation of developmental pigmentation|spleen development|thymus development|post-embryonic animal organ morphogenesis|positive regulation of apoptotic process by virus|thymocyte apoptotic process|cellular response to glucocorticoid stimulus|cellular response to estradiol stimulus|positive regulation of release of cytochrome c from mitochondria|Bcl-2 family protein complex|extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|apoptotic process involved in embryonic digit morphogenesis|positive regulation of IRE1-mediated unfolded protein response|cellular response to amyloid-beta|positive regulation of fibroblast apoptotic process|positive regulation of intrinsic apoptotic signaling pathway "hsa01521,hsa04068,hsa04151,hsa04210,hsa04215,hsa04932,hsa05169,hsa05200,hsa05206,hsa05210" EGFR tyrosine kinase inhibitor resistance|FoxO signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Apoptosis - multiple species|Non-alcoholic fatty liver disease|Epstein-Barr virus infection|Pathways in cancer|MicroRNAs in cancer|Colorectal cancer BCL2L12 481.2687201 472.3479027 490.1895376 1.037772233 0.05348984 0.853364598 1 11.65434093 11.89216547 83596 BCL2 like 12 "GO:0002039,GO:0005634,GO:0006915,GO:0016020,GO:0045944,GO:1902166,GO:1990001,GO:2000773,GO:2001236" p53 binding|nucleus|apoptotic process|membrane|positive regulation of transcription by RNA polymerase II|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|inhibition of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of cellular senescence|regulation of extrinsic apoptotic signaling pathway BCL2L13 1664.573277 1661.540971 1667.605584 1.003649993 0.00525624 0.98521923 1 15.14748682 14.94837719 23786 BCL2 like 13 "GO:0005515,GO:0005634,GO:0005739,GO:0006915,GO:0006919,GO:0008656,GO:0016021,GO:0031966,GO:0042981" protein binding|nucleus|mitochondrion|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cysteine-type endopeptidase activator activity involved in apoptotic process|integral component of membrane|mitochondrial membrane|regulation of apoptotic process "hsa04137,hsa05134" Mitophagy - animal|Legionellosis BCL2L14 2.080827765 4.161655531 0 0 #NAME? 0.234194363 1 0.075518499 0 79370 BCL2 like 14 "GO:0005515,GO:0005829,GO:0006915,GO:0012505,GO:0016020,GO:0019901,GO:0042981,GO:0043229,GO:2001236" protein binding|cytosol|apoptotic process|endomembrane system|membrane|protein kinase binding|regulation of apoptotic process|intracellular organelle|regulation of extrinsic apoptotic signaling pathway BCL2L15 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.022187803 0.030231832 440603 BCL2 like 15 "GO:0005515,GO:0005634,GO:0005829,GO:0006915,GO:0042981" protein binding|nucleus|cytosol|apoptotic process|regulation of apoptotic process BCL2L2 1053.827134 994.6356718 1113.018597 1.119021395 0.16223762 0.50879508 1 15.05441796 16.56431719 599 BCL2 like 2 "GO:0005515,GO:0005741,GO:0007283,GO:0008630,GO:0042802,GO:0042803,GO:0043066,GO:0046982,GO:0097136,GO:0097192,GO:0097718,GO:2001243" protein binding|mitochondrial outer membrane|spermatogenesis|intrinsic apoptotic signaling pathway in response to DNA damage|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|protein heterodimerization activity|Bcl-2 family protein complex|extrinsic apoptotic signaling pathway in absence of ligand|disordered domain specific binding|negative regulation of intrinsic apoptotic signaling pathway hsa05206 MicroRNAs in cancer BCL2L2-PABPN1 6.886607545 4.161655531 9.61155956 2.309551929 1.207612985 0.417805055 1 0.09871107 0.224163433 100529063 BCL2L2-PABPN1 readthrough "hsa03015,hsa05164" mRNA surveillance pathway|Influenza A BCL3 313.9539707 356.8619617 271.0459796 0.759526116 -0.396828524 0.201042125 1 3.81358971 2.848051623 602 BCL3 transcription coactivator "GO:0000978,GO:0002268,GO:0002315,GO:0002455,GO:0002467,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006351,GO:0006974,GO:0007249,GO:0008134,GO:0009615,GO:0010225,GO:0019730,GO:0030198,GO:0030330,GO:0030496,GO:0030674,GO:0032717,GO:0032720,GO:0032729,GO:0032733,GO:0032991,GO:0032996,GO:0033257,GO:0042088,GO:0042742,GO:0042771,GO:0042832,GO:0042981,GO:0043066,GO:0043231,GO:0045064,GO:0045727,GO:0045892,GO:0045893,GO:0045944,GO:0046426,GO:0048471,GO:0048536,GO:0051101,GO:0051457,GO:1901222" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|follicular dendritic cell differentiation|marginal zone B cell differentiation|humoral immune response mediated by circulating immunoglobulin|germinal center formation|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|transcription, DNA-templated|cellular response to DNA damage stimulus|I-kappaB kinase/NF-kappaB signaling|transcription factor binding|response to virus|response to UV-C|antimicrobial humoral response|extracellular matrix organization|DNA damage response, signal transduction by p53 class mediator|midbody|protein-macromolecule adaptor activity|negative regulation of interleukin-8 production|negative regulation of tumor necrosis factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|protein-containing complex|Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|T-helper 1 type immune response|defense response to bacterium|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|defense response to protozoan|regulation of apoptotic process|negative regulation of apoptotic process|intracellular membrane-bounded organelle|T-helper 2 cell differentiation|positive regulation of translation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of receptor signaling pathway via JAK-STAT|perinuclear region of cytoplasm|spleen development|regulation of DNA binding|maintenance of protein location in nucleus|regulation of NIK/NF-kappaB signaling" "hsa04625,hsa04668" C-type lectin receptor signaling pathway|TNF signaling pathway other BCL6 583.6161238 610.7229491 556.5092985 0.911230369 -0.134112265 0.615578938 1 3.308278657 2.964158668 604 BCL6 transcription repressor "GO:0000122,GO:0000902,GO:0000978,GO:0001161,GO:0001227,GO:0001817,GO:0001953,GO:0002467,GO:0002634,GO:0002682,GO:0002903,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0005730,GO:0005794,GO:0006357,GO:0006954,GO:0006974,GO:0007266,GO:0007283,GO:0008104,GO:0008285,GO:0019221,GO:0030036,GO:0030183,GO:0030308,GO:0030890,GO:0031065,GO:0031490,GO:0032764,GO:0035024,GO:0042092,GO:0042127,GO:0042802,GO:0042981,GO:0043065,GO:0043087,GO:0043380,GO:0043565,GO:0045591,GO:0045595,GO:0045629,GO:0045666,GO:0045746,GO:0045892,GO:0046872,GO:0048294,GO:0048821,GO:0050727,GO:0050776,GO:0051272,GO:1903464,GO:1990837,GO:2000773" "negative regulation of transcription by RNA polymerase II|cell morphogenesis|RNA polymerase II cis-regulatory region sequence-specific DNA binding|intronic transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|regulation of cytokine production|negative regulation of cell-matrix adhesion|germinal center formation|regulation of germinal center formation|regulation of immune system process|negative regulation of B cell apoptotic process|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|replication fork|nucleolus|Golgi apparatus|regulation of transcription by RNA polymerase II|inflammatory response|cellular response to DNA damage stimulus|Rho protein signal transduction|spermatogenesis|protein localization|negative regulation of cell population proliferation|cytokine-mediated signaling pathway|actin cytoskeleton organization|B cell differentiation|negative regulation of cell growth|positive regulation of B cell proliferation|positive regulation of histone deacetylation|chromatin DNA binding|negative regulation of mast cell cytokine production|negative regulation of Rho protein signal transduction|type 2 immune response|regulation of cell population proliferation|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|regulation of GTPase activity|regulation of memory T cell differentiation|sequence-specific DNA binding|positive regulation of regulatory T cell differentiation|regulation of cell differentiation|negative regulation of T-helper 2 cell differentiation|positive regulation of neuron differentiation|negative regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|metal ion binding|negative regulation of isotype switching to IgE isotypes|erythrocyte development|regulation of inflammatory response|regulation of immune response|positive regulation of cellular component movement|negative regulation of mitotic cell cycle DNA replication|sequence-specific double-stranded DNA binding|negative regulation of cellular senescence" "hsa04068,hsa05202" FoxO signaling pathway|Transcriptional misregulation in cancer ZBTB BCL6B 7.525701377 8.323311061 6.728091692 0.808343175 -0.306960188 0.918003413 1 0.125942675 0.100101334 255877 BCL6B transcription repressor "GO:0000122,GO:0000978,GO:0001227,GO:0001817,GO:0002682,GO:0005654,GO:0006357,GO:0042092,GO:0042127,GO:0045595,GO:0046872,GO:0050727,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|regulation of cytokine production|regulation of immune system process|nucleoplasm|regulation of transcription by RNA polymerase II|type 2 immune response|regulation of cell population proliferation|regulation of cell differentiation|metal ion binding|regulation of inflammatory response|sequence-specific double-stranded DNA binding" BCL7A 376.0378486 333.9728563 418.1028409 1.251906653 0.324126994 0.271607057 1 4.788693586 5.894679199 605 BAF chromatin remodeling complex subunit BCL7A "GO:0003674,GO:0005515,GO:0005575,GO:0045892" "molecular_function|protein binding|cellular_component|negative regulation of transcription, DNA-templated" BCL7B 975.4142805 891.6346974 1059.193864 1.187923559 0.248442005 0.313833572 1 26.65821011 31.13799616 9275 BAF chromatin remodeling complex subunit BCL7B "GO:0003779,GO:0005515,GO:0005575,GO:0006915,GO:0008150,GO:0016055,GO:0030154" actin binding|protein binding|cellular_component|apoptotic process|biological_process|Wnt signaling pathway|cell differentiation BCL7C 561.9114713 507.7219747 616.1009678 1.213461301 0.279128099 0.295614582 1 8.291367392 9.892892008 9274 BAF chromatin remodeling complex subunit BCL7C GO:0006915 apoptotic process BCL9 366.7678584 380.791481 352.7442358 0.926344872 -0.110378695 0.716209345 1 3.306025944 3.011273053 607 BCL9 transcription coactivator "GO:0003713,GO:0005515,GO:0005654,GO:0005801,GO:0008013,GO:0014908,GO:0017015,GO:0035019,GO:0035914,GO:0045944,GO:0060070,GO:1904837,GO:1990907" transcription coactivator activity|protein binding|nucleoplasm|cis-Golgi network|beta-catenin binding|myotube differentiation involved in skeletal muscle regeneration|regulation of transforming growth factor beta receptor signaling pathway|somatic stem cell population maintenance|skeletal muscle cell differentiation|positive regulation of transcription by RNA polymerase II|canonical Wnt signaling pathway|beta-catenin-TCF complex assembly|beta-catenin-TCF complex BCL9L 3552.883386 4049.290831 3056.47594 0.754817588 -0.405800055 0.08759046 1 19.10220184 14.17740088 283149 BCL9 like "GO:0003713,GO:0005634,GO:0005654,GO:0005730,GO:0008013,GO:0010718,GO:0022604,GO:0030512,GO:0035019,GO:0035914,GO:0045944,GO:0060070,GO:1904837,GO:1990907" transcription coactivator activity|nucleus|nucleoplasm|nucleolus|beta-catenin binding|positive regulation of epithelial to mesenchymal transition|regulation of cell morphogenesis|negative regulation of transforming growth factor beta receptor signaling pathway|somatic stem cell population maintenance|skeletal muscle cell differentiation|positive regulation of transcription by RNA polymerase II|canonical Wnt signaling pathway|beta-catenin-TCF complex assembly|beta-catenin-TCF complex BCLAF1 2259.613832 2345.092891 2174.134772 0.927099639 -0.109203696 0.645065961 1 16.34068384 14.89593669 9774 BCL2 associated transcription factor 1 "GO:0003677,GO:0003712,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006915,GO:0016592,GO:0016607,GO:0043065,GO:0043620,GO:0045892,GO:0045944,GO:1990830,GO:2000144,GO:2001022,GO:2001244" "DNA binding|transcription coregulator activity|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|apoptotic process|mediator complex|nuclear speck|positive regulation of apoptotic process|regulation of DNA-templated transcription in response to stress|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cellular response to leukemia inhibitory factor|positive regulation of DNA-templated transcription, initiation|positive regulation of response to DNA damage stimulus|positive regulation of intrinsic apoptotic signaling pathway" BCLAF3 378.7376485 392.2360338 365.2392633 0.931172131 -0.102880215 0.732834406 1 2.811674442 2.574341638 256643 BCLAF1 and THRAP3 family member 3 "GO:0003677,GO:0003712,GO:0005739,GO:0016592,GO:0045944" DNA binding|transcription coregulator activity|mitochondrion|mediator complex|positive regulation of transcription by RNA polymerase II BCO2 33.0655313 35.37407201 30.75699059 0.869478373 -0.201777951 0.810082932 1 0.630333626 0.538890389 83875 beta-carotene oxygenase 2 "GO:0001523,GO:0003834,GO:0005739,GO:0005759,GO:0010436,GO:0016116,GO:0016119,GO:0016121,GO:0016122,GO:0016702,GO:0042573,GO:0042574,GO:0046872,GO:0051881,GO:0055114,GO:0102076,GO:2000377" "retinoid metabolic process|beta-carotene 15,15'-monooxygenase activity|mitochondrion|mitochondrial matrix|carotenoid dioxygenase activity|carotenoid metabolic process|carotene metabolic process|carotene catabolic process|xanthophyll metabolic process|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|retinoic acid metabolic process|retinal metabolic process|metal ion binding|regulation of mitochondrial membrane potential|oxidation-reduction process|beta,beta-carotene-9',10'-cleaving oxygenase activity|regulation of reactive oxygen species metabolic process" BCOR 1074.400826 1320.285217 828.5164341 0.627528373 -0.672247405 0.006014387 0.464919713 8.549040943 5.274993664 54880 BCL6 corepressor "GO:0000122,GO:0000415,GO:0000976,GO:0000977,GO:0001835,GO:0003714,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0007507,GO:0008134,GO:0030502,GO:0031072,GO:0035518,GO:0042476,GO:0042826,GO:0045892,GO:0051572,GO:0060021,GO:0065001,GO:0070171,GO:0140261" "negative regulation of transcription by RNA polymerase II|negative regulation of histone H3-K36 methylation|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|blastocyst hatching|transcription corepressor activity|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|heart development|transcription factor binding|negative regulation of bone mineralization|heat shock protein binding|histone H2A monoubiquitination|odontogenesis|histone deacetylase binding|negative regulation of transcription, DNA-templated|negative regulation of histone H3-K4 methylation|roof of mouth development|specification of axis polarity|negative regulation of tooth mineralization|BCOR complex" other BCORL1 1168.847589 1188.152654 1149.542523 0.967504066 -0.047660371 0.847496116 1 7.250946073 6.89792793 63035 BCL6 corepressor like 1 "GO:0005654,GO:0005886,GO:0006325" nucleoplasm|plasma membrane|chromatin organization BCR 1551.801613 1552.297513 1551.305713 0.999361076 -0.000922067 1 1 12.21336654 12.00131956 613 BCR activator of RhoGEF and GTPase "GO:0004674,GO:0005085,GO:0005096,GO:0005515,GO:0005524,GO:0005829,GO:0006468,GO:0007165,GO:0007264,GO:0016020,GO:0016301,GO:0019899,GO:0030216,GO:0030424,GO:0032991,GO:0035023,GO:0043197,GO:0046777,GO:0048008,GO:0048041,GO:0050804,GO:0051056,GO:0070062,GO:0090630,GO:0098685,GO:0098978,GO:0099092,GO:0106310,GO:0106311" "protein serine/threonine kinase activity|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|ATP binding|cytosol|protein phosphorylation|signal transduction|small GTPase mediated signal transduction|membrane|kinase activity|enzyme binding|keratinocyte differentiation|axon|protein-containing complex|regulation of Rho protein signal transduction|dendritic spine|protein autophosphorylation|platelet-derived growth factor receptor signaling pathway|focal adhesion assembly|modulation of chemical synaptic transmission|regulation of small GTPase mediated signal transduction|extracellular exosome|activation of GTPase activity|Schaffer collateral - CA1 synapse|glutamatergic synapse|postsynaptic density, intracellular component|protein serine kinase activity|protein threonine kinase activity" "hsa05200,hsa05220" Pathways in cancer|Chronic myeloid leukemia BCS1L 387.2194754 413.0443114 361.3946395 0.874953678 -0.192721455 0.512520741 1 13.1838611 11.34224067 617 "BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone" "GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0005750,GO:0007005,GO:0016021,GO:0016887,GO:0032979,GO:0032981,GO:0033617,GO:0034551" protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex III|mitochondrion organization|integral component of membrane|ATPase activity|protein insertion into mitochondrial inner membrane from matrix|mitochondrial respiratory chain complex I assembly|mitochondrial cytochrome c oxidase assembly|mitochondrial respiratory chain complex III assembly BDH1 362.6062029 372.46817 352.7442358 0.947045316 -0.078494634 0.799730409 1 1.823329817 1.697880706 622 3-hydroxybutyrate dehydrogenase 1 "GO:0003858,GO:0005739,GO:0005759,GO:0046951,GO:0046952,GO:0055114,GO:0099617" 3-hydroxybutyrate dehydrogenase activity|mitochondrion|mitochondrial matrix|ketone body biosynthetic process|ketone body catabolic process|oxidation-reduction process|matrix side of mitochondrial inner membrane "hsa00072,hsa00650" Synthesis and degradation of ketone bodies|Butanoate metabolism BDH2 474.278317 427.6101058 520.9465281 1.218274594 0.284839348 0.304470391 1 7.074012843 8.473878059 56898 3-hydroxybutyrate dehydrogenase 2 "GO:0003858,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0006635,GO:0016616,GO:0016628,GO:0019290,GO:0030855,GO:0042168,GO:0046951,GO:0051287,GO:0055072,GO:0070062" "3-hydroxybutyrate dehydrogenase activity|protein binding|cytoplasm|mitochondrion|cytosol|fatty acid beta-oxidation|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor|siderophore biosynthetic process|epithelial cell differentiation|heme metabolic process|ketone body biosynthetic process|NAD binding|iron ion homeostasis|extracellular exosome" "hsa00072,hsa00650" Synthesis and degradation of ketone bodies|Butanoate metabolism BDKRB1 4.042768641 5.202069413 2.883467868 0.554292463 -0.851280704 0.745112452 1 0.213393454 0.116303088 623 bradykinin receptor B1 "GO:0001933,GO:0002687,GO:0004930,GO:0004947,GO:0005515,GO:0005783,GO:0005886,GO:0005887,GO:0006954,GO:0007186,GO:0007204,GO:0007205,GO:0009612,GO:0016477,GO:0019233,GO:0030308,GO:0032496,GO:0042277,GO:0043005,GO:0045776,GO:0051281" negative regulation of protein phosphorylation|positive regulation of leukocyte migration|G protein-coupled receptor activity|bradykinin receptor activity|protein binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|inflammatory response|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|protein kinase C-activating G protein-coupled receptor signaling pathway|response to mechanical stimulus|cell migration|sensory perception of pain|negative regulation of cell growth|response to lipopolysaccharide|peptide binding|neuron projection|negative regulation of blood pressure|positive regulation of release of sequestered calcium ion into cytosol "hsa04020,hsa04080,hsa04610,hsa04750,hsa04810,hsa05200" Calcium signaling pathway|Neuroactive ligand-receptor interaction|Complement and coagulation cascades|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Pathways in cancer BDKRB2 28.10123567 31.21241648 24.99005486 0.800644669 -0.320765987 0.698936571 1 0.41685418 0.328167188 624 bradykinin receptor B2 "GO:0002020,GO:0004435,GO:0004930,GO:0004947,GO:0005515,GO:0005768,GO:0005794,GO:0005886,GO:0005887,GO:0006939,GO:0006954,GO:0007166,GO:0007169,GO:0007186,GO:0007204,GO:0008015,GO:0009651,GO:0019229,GO:0031702,GO:0033137,GO:0042310,GO:0042311,GO:0043114,GO:0043231,GO:0046982,GO:0050482,GO:1902239" protease binding|phosphatidylinositol phospholipase C activity|G protein-coupled receptor activity|bradykinin receptor activity|protein binding|endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|smooth muscle contraction|inflammatory response|cell surface receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|blood circulation|response to salt stress|regulation of vasoconstriction|type 1 angiotensin receptor binding|negative regulation of peptidyl-serine phosphorylation|vasoconstriction|vasodilation|regulation of vascular permeability|intracellular membrane-bounded organelle|protein heterodimerization activity|arachidonic acid secretion|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator "hsa04020,hsa04022,hsa04071,hsa04080,hsa04610,hsa04750,hsa04810,hsa04961,hsa05142,hsa05200" Calcium signaling pathway|cGMP-PKG signaling pathway|Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction|Complement and coagulation cascades|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Endocrine and other factor-regulated calcium reabsorption|Chagas disease|Pathways in cancer BDNF 401.7707929 378.7106533 424.8309325 1.121782366 0.165792809 0.570407249 1 2.39638268 2.643236114 627 brain derived neurotrophic factor "GO:0005163,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005739,GO:0007169,GO:0007202,GO:0007399,GO:0007411,GO:0007416,GO:0007422,GO:0007613,GO:0008021,GO:0008083,GO:0010832,GO:0010976,GO:0016607,GO:0021675,GO:0030424,GO:0030425,GO:0031547,GO:0031550,GO:0033138,GO:0038180,GO:0043524,GO:0045664,GO:0048011,GO:0048471,GO:0048668,GO:0048672,GO:0048812,GO:0050804,GO:0051965,GO:1900122,GO:1903997,GO:2000008,GO:2001234" nerve growth factor receptor binding|protein binding|extracellular region|extracellular space|cytoplasm|mitochondrion|transmembrane receptor protein tyrosine kinase signaling pathway|activation of phospholipase C activity|nervous system development|axon guidance|synapse assembly|peripheral nervous system development|memory|synaptic vesicle|growth factor activity|negative regulation of myotube differentiation|positive regulation of neuron projection development|nuclear speck|nerve development|axon|dendrite|brain-derived neurotrophic factor receptor signaling pathway|positive regulation of brain-derived neurotrophic factor receptor signaling pathway|positive regulation of peptidyl-serine phosphorylation|nerve growth factor signaling pathway|negative regulation of neuron apoptotic process|regulation of neuron differentiation|neurotrophin TRK receptor signaling pathway|perinuclear region of cytoplasm|collateral sprouting|positive regulation of collateral sprouting|neuron projection morphogenesis|modulation of chemical synaptic transmission|positive regulation of synapse assembly|positive regulation of receptor binding|positive regulation of non-membrane spanning protein tyrosine kinase activity|regulation of protein localization to cell surface|negative regulation of apoptotic signaling pathway "hsa04010,hsa04014,hsa04024,hsa04151,hsa04722,hsa05016,hsa05022,hsa05030,hsa05034" MAPK signaling pathway|Ras signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|Neurotrophin signaling pathway|Huntington disease|Pathways of neurodegeneration - multiple diseases|Cocaine addiction|Alcoholism BDP1 1730.549626 1917.482786 1543.616465 0.805022333 -0.312899288 0.187374225 1 7.501835063 5.938087854 55814 "B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB" "GO:0000126,GO:0001156,GO:0005654,GO:0070898" transcription factor TFIIIB complex|TFIIIC-class transcription factor complex binding|nucleoplasm|RNA polymerase III preinitiation complex assembly other BEAN1 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.020146944 0.012200477 146227 brain expressed associated with NEDD4 1 GO:0016021 integral component of membrane hsa05017 Spinocerebellar ataxia BECN1 1570.162956 1504.438474 1635.887437 1.087374103 0.120848375 0.613230437 1 35.54188417 38.00061379 8678 beclin 1 "GO:0000045,GO:0000407,GO:0000422,GO:0000423,GO:0001666,GO:0005515,GO:0005634,GO:0005739,GO:0005768,GO:0005776,GO:0005783,GO:0005789,GO:0005802,GO:0005829,GO:0006914,GO:0006915,GO:0006968,GO:0006995,GO:0007040,GO:0007080,GO:0007568,GO:0008285,GO:0010008,GO:0010040,GO:0010288,GO:0010613,GO:0014068,GO:0016032,GO:0016236,GO:0016579,GO:0019898,GO:0019901,GO:0030425,GO:0031625,GO:0031966,GO:0032465,GO:0032801,GO:0033197,GO:0034198,GO:0034271,GO:0034272,GO:0035032,GO:0042149,GO:0042493,GO:0042802,GO:0043066,GO:0043548,GO:0043652,GO:0045022,GO:0045324,GO:0045335,GO:0048666,GO:0050435,GO:0050790,GO:0051020,GO:0051301,GO:0051607,GO:0060548,GO:0070301,GO:0071275,GO:0071280,GO:0071364,GO:0098780,GO:1902425,GO:1902902,GO:1905672,GO:2000378,GO:2000786,GO:2001244" "autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|mitophagy|response to hypoxia|protein binding|nucleus|mitochondrion|endosome|autophagosome|endoplasmic reticulum|endoplasmic reticulum membrane|trans-Golgi network|cytosol|autophagy|apoptotic process|cellular defense response|cellular response to nitrogen starvation|lysosome organization|mitotic metaphase plate congression|aging|negative regulation of cell population proliferation|endosome membrane|response to iron(II) ion|response to lead ion|positive regulation of cardiac muscle hypertrophy|positive regulation of phosphatidylinositol 3-kinase signaling|viral process|macroautophagy|protein deubiquitination|extrinsic component of membrane|protein kinase binding|dendrite|ubiquitin protein ligase binding|mitochondrial membrane|regulation of cytokinesis|receptor catabolic process|response to vitamin E|cellular response to amino acid starvation|phosphatidylinositol 3-kinase complex, class III, type I|phosphatidylinositol 3-kinase complex, class III, type II|phosphatidylinositol 3-kinase complex, class III|cellular response to glucose starvation|response to drug|identical protein binding|negative regulation of apoptotic process|phosphatidylinositol 3-kinase binding|engulfment of apoptotic cell|early endosome to late endosome transport|late endosome to vacuole transport|phagocytic vesicle|neuron development|amyloid-beta metabolic process|regulation of catalytic activity|GTPase binding|cell division|defense response to virus|negative regulation of cell death|cellular response to hydrogen peroxide|cellular response to aluminum ion|cellular response to copper ion|cellular response to epidermal growth factor stimulus|response to mitochondrial depolarisation|positive regulation of attachment of mitotic spindle microtubules to kinetochore|negative regulation of autophagosome assembly|negative regulation of lysosome organization|negative regulation of reactive oxygen species metabolic process|positive regulation of autophagosome assembly|positive regulation of intrinsic apoptotic signaling pathway" "hsa04136,hsa04137,hsa04140,hsa04215,hsa04371,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022,hsa05131,hsa05167" Autophagy - other|Mitophagy - animal|Autophagy - animal|Apoptosis - multiple species|Apelin signaling pathway|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis|Kaposi sarcoma-associated herpesvirus infection BEGAIN 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.011761274 0.042733974 57596 brain enriched guanylate kinase associated "GO:0005515,GO:0005737,GO:0016020,GO:0045202,GO:0098962" protein binding|cytoplasm|membrane|synapse|regulation of postsynaptic neurotransmitter receptor activity BEND3 90.5461903 106.122216 74.97016457 0.706451178 -0.501338233 0.303443966 1 0.862556751 0.599157515 57673 BEN domain containing 3 "GO:0000122,GO:0000182,GO:0000183,GO:0000792,GO:0005515,GO:0005654,GO:0005730,GO:0006306,GO:0034773,GO:0036124,GO:0043967,GO:0051260,GO:0080182,GO:0098532,GO:1903580" negative regulation of transcription by RNA polymerase II|rDNA binding|rDNA heterochromatin assembly|heterochromatin|protein binding|nucleoplasm|nucleolus|DNA methylation|histone H4-K20 trimethylation|histone H3-K9 trimethylation|histone H4 acetylation|protein homooligomerization|histone H3-K4 trimethylation|histone H3-K27 trimethylation|positive regulation of ATP metabolic process BEND4 62.48961401 63.46524684 61.51398118 0.96925458 -0.045052447 0.966973776 1 0.392425394 0.3739953 389206 BEN domain containing 4 BEND7 252.4406039 255.9418151 248.9393926 0.972640569 -0.040021328 0.91688993 1 2.69304895 2.575537074 222389 BEN domain containing 7 "GO:0005515,GO:0070062" protein binding|extracellular exosome BEST1 22.45318682 34.33365813 10.57271552 0.307940257 -1.699277611 0.039961777 1 0.346768401 0.104997066 7439 bestrophin 1 "GO:0005254,GO:0005829,GO:0005886,GO:0006821,GO:0007601,GO:0009925,GO:0016020,GO:0016021,GO:0016323,GO:0030321,GO:0034220,GO:0034707,GO:0042802,GO:0050908,GO:0051924,GO:1902476" chloride channel activity|cytosol|plasma membrane|chloride transport|visual perception|basal plasma membrane|membrane|integral component of membrane|basolateral plasma membrane|transepithelial chloride transport|ion transmembrane transport|chloride channel complex|identical protein binding|detection of light stimulus involved in visual perception|regulation of calcium ion transport|chloride transmembrane transport BEST2 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.08283189 0.050160887 54831 bestrophin 2 "GO:0003674,GO:0005254,GO:0005515,GO:0005886,GO:0005929,GO:0007608,GO:0008150,GO:0034707,GO:0051899,GO:1902476" molecular_function|chloride channel activity|protein binding|plasma membrane|cilium|sensory perception of smell|biological_process|chloride channel complex|membrane depolarization|chloride transmembrane transport hsa04970 Salivary secretion BEST3 16.49313669 16.64662212 16.33965125 0.98155957 -0.026852269 1 1 0.140015702 0.135133984 144453 bestrophin 3 "GO:0003674,GO:0005254,GO:0005886,GO:0008150,GO:0034707,GO:0043271,GO:1902476" molecular_function|chloride channel activity|plasma membrane|biological_process|chloride channel complex|negative regulation of ion transport|chloride transmembrane transport BEST4 18.85639761 15.60620824 22.10658699 1.416525183 0.502356251 0.597410597 1 0.291113125 0.405468635 266675 bestrophin 4 "GO:0003674,GO:0005254,GO:0005886,GO:0008150,GO:0034707,GO:1902476" molecular_function|chloride channel activity|plasma membrane|biological_process|chloride channel complex|chloride transmembrane transport BET1 1075.626751 961.3424276 1189.911074 1.237759865 0.307731448 0.207894141 1 34.64218669 42.16119121 10282 Bet1 golgi vesicular membrane trafficking protein "GO:0000138,GO:0000139,GO:0005484,GO:0005515,GO:0005789,GO:0006888,GO:0015031,GO:0016020,GO:0030133,GO:0030173,GO:0031201,GO:0033116,GO:0048208,GO:0048280" Golgi trans cisterna|Golgi membrane|SNAP receptor activity|protein binding|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|protein transport|membrane|transport vesicle|integral component of Golgi membrane|SNARE complex|endoplasmic reticulum-Golgi intermediate compartment membrane|COPII vesicle coating|vesicle fusion with Golgi apparatus hsa04130 SNARE interactions in vesicular transport BET1L 1244.576348 1094.515405 1394.637292 1.274205266 0.349597705 0.147684577 1 19.91553887 24.9518434 51272 Bet1 golgi vesicular membrane trafficking protein like "GO:0000138,GO:0000139,GO:0005484,GO:0005768,GO:0005794,GO:0005829,GO:0006888,GO:0015031,GO:0016020,GO:0030173,GO:0031201,GO:0042147,GO:0061025,GO:2000156" "Golgi trans cisterna|Golgi membrane|SNAP receptor activity|endosome|Golgi apparatus|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|protein transport|membrane|integral component of Golgi membrane|SNARE complex|retrograde transport, endosome to Golgi|membrane fusion|regulation of retrograde vesicle-mediated transport, Golgi to ER" hsa04130 SNARE interactions in vesicular transport BEX2 5.083182523 7.282897178 2.883467868 0.395923188 -1.336707531 0.4551609 1 0.347031104 0.135098497 84707 brain expressed X-linked 2 "GO:0005102,GO:0005515,GO:0005634,GO:0005737,GO:0006915,GO:0007049,GO:0007165,GO:0042981,GO:0051726" signaling receptor binding|protein binding|nucleus|cytoplasm|apoptotic process|cell cycle|signal transduction|regulation of apoptotic process|regulation of cell cycle BEX3 3117.473248 2673.863678 3561.082817 1.331811657 0.413390073 0.081128358 1 99.92940488 130.8601132 27018 brain expressed X-linked 3 "GO:0005102,GO:0005163,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0006919,GO:0007165,GO:0007275,GO:0008656,GO:0042802,GO:0043154,GO:0043281,GO:0046872" signaling receptor binding|nerve growth factor receptor binding|protein binding|nucleus|cytoplasm|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|multicellular organism development|cysteine-type endopeptidase activator activity involved in apoptotic process|identical protein binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of cysteine-type endopeptidase activity involved in apoptotic process|metal ion binding hsa04722 Neurotrophin signaling pathway BEX4 3.121241648 6.242483296 0 0 #NAME? 0.093640883 1 0.250865859 0 56271 brain expressed X-linked 4 "GO:0000922,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005874,GO:0007059,GO:0030334,GO:0042127,GO:0042826,GO:0043014,GO:1904428" spindle pole|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|microtubule|chromosome segregation|regulation of cell migration|regulation of cell population proliferation|histone deacetylase binding|alpha-tubulin binding|negative regulation of tubulin deacetylation BEX5 12.45036805 11.44455271 13.45618338 1.175771891 0.233608194 0.899941244 1 0.626435635 0.724220321 340542 brain expressed X-linked 5 "GO:0005102,GO:0005515,GO:0005737,GO:0007165" signaling receptor binding|protein binding|cytoplasm|signal transduction BFAR 1297.61672 1351.497634 1243.735807 0.92026488 -0.119878923 0.620124285 1 23.85939291 21.58954133 51283 bifunctional apoptosis regulator "GO:0000209,GO:0005515,GO:0005783,GO:0005887,GO:0006511,GO:0006915,GO:0016020,GO:0030176,GO:0030674,GO:0043066,GO:0043161,GO:0046872,GO:0051865,GO:0061630,GO:0070534,GO:0070936,GO:0089720,GO:1903895" protein polyubiquitination|protein binding|endoplasmic reticulum|integral component of plasma membrane|ubiquitin-dependent protein catabolic process|apoptotic process|membrane|integral component of endoplasmic reticulum membrane|protein-macromolecule adaptor activity|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|caspase binding|negative regulation of IRE1-mediated unfolded protein response BFSP1 20.77367911 28.09117483 13.45618338 0.479018178 -1.06184769 0.20928515 1 0.518386712 0.244161415 631 beaded filament structural protein 1 "GO:0005200,GO:0005212,GO:0005515,GO:0005737,GO:0005882,GO:0005886,GO:0005938,GO:0008150,GO:0045109,GO:0048469,GO:0070307" structural constituent of cytoskeleton|structural constituent of eye lens|protein binding|cytoplasm|intermediate filament|plasma membrane|cell cortex|biological_process|intermediate filament organization|cell maturation|lens fiber cell development BGN 20.2138432 26.01034707 14.41733934 0.554292463 -0.851280704 0.32434086 1 0.590942707 0.322073898 633 biglycan "GO:0001974,GO:0005201,GO:0005515,GO:0005539,GO:0005576,GO:0005615,GO:0005796,GO:0008150,GO:0009986,GO:0019800,GO:0030021,GO:0030133,GO:0030198,GO:0030206,GO:0030207,GO:0030208,GO:0031012,GO:0042383,GO:0043202,GO:0050840,GO:0060348,GO:0061975,GO:0062023,GO:0070062" blood vessel remodeling|extracellular matrix structural constituent|protein binding|glycosaminoglycan binding|extracellular region|extracellular space|Golgi lumen|biological_process|cell surface|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|extracellular matrix structural constituent conferring compression resistance|transport vesicle|extracellular matrix organization|chondroitin sulfate biosynthetic process|chondroitin sulfate catabolic process|dermatan sulfate biosynthetic process|extracellular matrix|sarcolemma|lysosomal lumen|extracellular matrix binding|bone development|articular cartilage development|collagen-containing extracellular matrix|extracellular exosome BHLHA15 6.004709516 6.242483296 5.766935736 0.923820772 -0.11431511 1 1 0.102130552 0.0927715 168620 basic helix-loop-helix family member a15 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0006851,GO:0007030,GO:0007186,GO:0007267,GO:0010832,GO:0019722,GO:0030182,GO:0030968,GO:0042149,GO:0042593,GO:0042802,GO:0045944,GO:0046983,GO:0048312,GO:0048469,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|mitochondrial calcium ion transmembrane transport|Golgi organization|G protein-coupled receptor signaling pathway|cell-cell signaling|negative regulation of myotube differentiation|calcium-mediated signaling|neuron differentiation|endoplasmic reticulum unfolded protein response|cellular response to glucose starvation|glucose homeostasis|identical protein binding|positive regulation of transcription by RNA polymerase II|protein dimerization activity|intracellular distribution of mitochondria|cell maturation|sequence-specific double-stranded DNA binding" hsa04950 Maturity onset diabetes of the young BHLHE40 3573.858896 3477.063196 3670.654596 1.055676699 0.078168077 0.742795852 1 58.55616036 60.78196076 8553 basic helix-loop-helix family member e40 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001102,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005737,GO:0006355,GO:0006357,GO:0007623,GO:0009952,GO:0016604,GO:0019904,GO:0032922,GO:0042752,GO:0042803,GO:0043153,GO:0043425,GO:0043426,GO:0043433,GO:0045892,GO:0046982,GO:0050767,GO:0070888,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II activating transcription factor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|circadian rhythm|anterior/posterior pattern specification|nuclear body|protein domain specific binding|circadian regulation of gene expression|regulation of circadian rhythm|protein homodimerization activity|entrainment of circadian clock by photoperiod|bHLH transcription factor binding|MRF binding|negative regulation of DNA-binding transcription factor activity|negative regulation of transcription, DNA-templated|protein heterodimerization activity|regulation of neurogenesis|E-box binding|sequence-specific double-stranded DNA binding" hsa04710 Circadian rhythm bHLH BHLHE41 664.8036196 685.6327487 643.9744905 0.939241149 -0.09043248 0.730562127 1 9.775837472 9.028222678 79365 basic helix-loop-helix family member e41 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001102,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0009952,GO:0010832,GO:0010944,GO:0032922,GO:0042803,GO:0042826,GO:0043425,GO:0043426,GO:0045892,GO:0046982,GO:0050767,GO:0070888,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II activating transcription factor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|negative regulation of myotube differentiation|negative regulation of transcription by competitive promoter binding|circadian regulation of gene expression|protein homodimerization activity|histone deacetylase binding|bHLH transcription factor binding|MRF binding|negative regulation of transcription, DNA-templated|protein heterodimerization activity|regulation of neurogenesis|E-box binding|sequence-specific double-stranded DNA binding" hsa04710 Circadian rhythm BICC1 873.7053562 858.3414532 889.0692593 1.035799047 0.050744136 0.842830002 1 2.761520725 2.812515941 80114 BicC family RNA binding protein 1 "GO:0001822,GO:0003723,GO:0005737,GO:0007368,GO:0007507,GO:0090090" kidney development|RNA binding|cytoplasm|determination of left/right symmetry|heart development|negative regulation of canonical Wnt signaling pathway BICD1 497.1573615 498.3582498 495.9564733 0.995180623 -0.0069697 0.988026605 1 2.055050521 2.010923701 636 BICD cargo adaptor 1 "GO:0005200,GO:0005515,GO:0005794,GO:0005802,GO:0005813,GO:0005829,GO:0005856,GO:0005881,GO:0006396,GO:0008093,GO:0008298,GO:0009653,GO:0016020,GO:0016032,GO:0019901,GO:0031267,GO:0031410,GO:0031871,GO:0033365,GO:0034063,GO:0034452,GO:0045298,GO:0045505,GO:0048260,GO:0048471,GO:0070507,GO:0070840,GO:0072385,GO:0072393,GO:0099503,GO:1900275,GO:1900276,GO:1900737,GO:1904781" structural constituent of cytoskeleton|protein binding|Golgi apparatus|trans-Golgi network|centrosome|cytosol|cytoskeleton|cytoplasmic microtubule|RNA processing|cytoskeletal anchor activity|intracellular mRNA localization|anatomical structure morphogenesis|membrane|viral process|protein kinase binding|small GTPase binding|cytoplasmic vesicle|proteinase activated receptor binding|protein localization to organelle|stress granule assembly|dynactin binding|tubulin complex|dynein intermediate chain binding|positive regulation of receptor-mediated endocytosis|perinuclear region of cytoplasm|regulation of microtubule cytoskeleton organization|dynein complex binding|minus-end-directed organelle transport along microtubule|microtubule anchoring at microtubule organizing center|secretory vesicle|negative regulation of phospholipase C activity|regulation of proteinase activated receptor activity|negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of protein localization to centrosome BICD2 1834.623039 1747.895323 1921.350756 1.09923674 0.136502129 0.565596971 1 14.26984257 15.42345234 23299 BICD cargo adaptor 2 "GO:0005515,GO:0005635,GO:0005642,GO:0005643,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0005886,GO:0006890,GO:0007018,GO:0008093,GO:0015031,GO:0031267,GO:0031410,GO:0033365,GO:0034067,GO:0034452,GO:0051028,GO:0051642,GO:0051959,GO:0070507,GO:0070840,GO:0072385,GO:0072393" "protein binding|nuclear envelope|annulate lamellae|nuclear pore|cytoplasm|Golgi apparatus|centrosome|cytosol|plasma membrane|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|cytoskeletal anchor activity|protein transport|small GTPase binding|cytoplasmic vesicle|protein localization to organelle|protein localization to Golgi apparatus|dynactin binding|mRNA transport|centrosome localization|dynein light intermediate chain binding|regulation of microtubule cytoskeleton organization|dynein complex binding|minus-end-directed organelle transport along microtubule|microtubule anchoring at microtubule organizing center" BICDL1 3.081612685 5.202069413 0.961155956 0.184764154 -2.436243205 0.338470402 1 0.05234255 0.009509195 92558 BICD family like cargo adaptor 1 "GO:0005737,GO:0005813,GO:0031175,GO:0031267,GO:0034452,GO:0047496,GO:0055107" cytoplasm|centrosome|neuron projection development|small GTPase binding|dynactin binding|vesicle transport along microtubule|Golgi to secretory granule transport BICRA 179.2197585 188.3149128 170.1246042 0.903404843 -0.146555447 0.70957605 1 1.391391497 1.235955795 29998 BRD4 interacting chromatin remodeling complex associated protein "GO:0003713,GO:0005515,GO:0005634,GO:0016514,GO:0045893,GO:0140537" "transcription coactivator activity|protein binding|nucleus|SWI/SNF complex|positive regulation of transcription, DNA-templated|transcription regulator activator activity" BICRAL 337.7300045 388.0743782 287.3856308 0.740542656 -0.433345256 0.153210581 1 2.990731598 2.17770324 23506 BRD4 interacting chromatin remodeling complex associated protein like "GO:0003713,GO:0005515,GO:0016514,GO:0045893" "transcription coactivator activity|protein binding|SWI/SNF complex|positive regulation of transcription, DNA-templated" BID 608.0211907 671.0669543 544.975427 0.812102911 -0.300265535 0.252644981 1 13.45364763 10.74291883 637 BH3 interacting domain death agonist "GO:0001836,GO:0005123,GO:0005515,GO:0005739,GO:0005741,GO:0005829,GO:0006626,GO:0006919,GO:0008625,GO:0008637,GO:0010918,GO:0016020,GO:0031334,GO:0031625,GO:0032592,GO:0042127,GO:0042770,GO:0042775,GO:0042981,GO:0043065,GO:0043066,GO:0051402,GO:0065003,GO:0090150,GO:0090200,GO:0097284,GO:0097345,GO:1900740,GO:1901030,GO:1902230,GO:2000045,GO:2000271,GO:2001238,GO:2001244" release of cytochrome c from mitochondria|death receptor binding|protein binding|mitochondrion|mitochondrial outer membrane|cytosol|protein targeting to mitochondrion|activation of cysteine-type endopeptidase activity involved in apoptotic process|extrinsic apoptotic signaling pathway via death domain receptors|apoptotic mitochondrial changes|positive regulation of mitochondrial membrane potential|membrane|positive regulation of protein-containing complex assembly|ubiquitin protein ligase binding|integral component of mitochondrial membrane|regulation of cell population proliferation|signal transduction in response to DNA damage|mitochondrial ATP synthesis coupled electron transport|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|neuron apoptotic process|protein-containing complex assembly|establishment of protein localization to membrane|positive regulation of release of cytochrome c from mitochondria|hepatocyte apoptotic process|mitochondrial outer membrane permeabilization|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|regulation of G1/S transition of mitotic cell cycle|positive regulation of fibroblast apoptotic process|positive regulation of extrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway "hsa01524,hsa04071,hsa04115,hsa04210,hsa04215,hsa04217,hsa04650,hsa04932,hsa05010,hsa05014,hsa05022,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05416" Platinum drug resistance|Sphingolipid signaling pathway|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Necroptosis|Natural killer cell mediated cytotoxicity|Non-alcoholic fatty liver disease|Alzheimer disease|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral myocarditis BIK 52.00118684 53.06110801 50.94126567 0.960049037 -0.058819997 0.956064849 1 2.977680139 2.810882161 638 BCL2 interacting killer "GO:0005515,GO:0006915,GO:0008584,GO:0008637,GO:0012505,GO:0016021,GO:0031334,GO:0031966,GO:0042981,GO:0090200" protein binding|apoptotic process|male gonad development|apoptotic mitochondrial changes|endomembrane system|integral component of membrane|positive regulation of protein-containing complex assembly|mitochondrial membrane|regulation of apoptotic process|positive regulation of release of cytochrome c from mitochondria hsa01522 Endocrine resistance BIN1 1002.321002 1005.039811 999.6021942 0.994589651 -0.007826676 0.979149649 1 14.35299104 14.03645792 274 bridging integrator 1 "GO:0002020,GO:0005515,GO:0005543,GO:0005634,GO:0005635,GO:0005737,GO:0005768,GO:0005829,GO:0005856,GO:0005886,GO:0006897,GO:0006997,GO:0007010,GO:0008021,GO:0008333,GO:0015629,GO:0016020,GO:0016032,GO:0019828,GO:0030018,GO:0030100,GO:0030276,GO:0030315,GO:0030424,GO:0030425,GO:0030838,GO:0031674,GO:0031982,GO:0033268,GO:0033292,GO:0042802,GO:0043065,GO:0043194,GO:0045664,GO:0048156,GO:0048711,GO:0051015,GO:0051087,GO:0051647,GO:0060987,GO:0060988,GO:0061024,GO:0070063,GO:0071156,GO:0086091,GO:1901380,GO:1902430,GO:1902960,GO:1903946,GO:1904878" protease binding|protein binding|phospholipid binding|nucleus|nuclear envelope|cytoplasm|endosome|cytosol|cytoskeleton|plasma membrane|endocytosis|nucleus organization|cytoskeleton organization|synaptic vesicle|endosome to lysosome transport|actin cytoskeleton|membrane|viral process|aspartic-type endopeptidase inhibitor activity|Z disc|regulation of endocytosis|clathrin binding|T-tubule|axon|dendrite|positive regulation of actin filament polymerization|I band|vesicle|node of Ranvier|T-tubule organization|identical protein binding|positive regulation of apoptotic process|axon initial segment|regulation of neuron differentiation|tau protein binding|positive regulation of astrocyte differentiation|actin filament binding|chaperone binding|nucleus localization|lipid tube|lipid tube assembly|membrane organization|RNA polymerase binding|regulation of cell cycle arrest|regulation of heart rate by cardiac conduction|negative regulation of potassium ion transmembrane transport|negative regulation of amyloid-beta formation|negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of ventricular cardiac muscle cell action potential|negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel "hsa04144,hsa04666" Endocytosis|Fc gamma R-mediated phagocytosis BIN3 331.9636832 287.1542316 376.7731347 1.31209327 0.391870277 0.199463977 1 5.076148915 6.548928375 55909 bridging integrator 3 "GO:0000917,GO:0005515,GO:0005737,GO:0006897,GO:0007015,GO:0008093,GO:0008104,GO:0008289,GO:0009826,GO:0010591,GO:0014839,GO:0015629,GO:0048741,GO:0051666,GO:0061640,GO:0097320" division septum assembly|protein binding|cytoplasm|endocytosis|actin filament organization|cytoskeletal anchor activity|protein localization|lipid binding|unidimensional cell growth|regulation of lamellipodium assembly|myoblast migration involved in skeletal muscle regeneration|actin cytoskeleton|skeletal muscle fiber development|actin cortical patch localization|cytoskeleton-dependent cytokinesis|plasma membrane tubulation BIRC2 2205.355637 1929.967752 2480.743522 1.285380815 0.362195845 0.125603224 1 24.33234864 30.75296704 329 baculoviral IAP repeat containing 2 "GO:0000209,GO:0001666,GO:0001741,GO:0001890,GO:0002756,GO:0003713,GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0007166,GO:0007249,GO:0008270,GO:0009898,GO:0010803,GO:0016579,GO:0016740,GO:0031398,GO:0033209,GO:0034121,GO:0035631,GO:0035666,GO:0038061,GO:0039535,GO:0042127,GO:0042802,GO:0042981,GO:0043027,GO:0043066,GO:0043123,GO:0043130,GO:0043161,GO:0044877,GO:0045088,GO:0045121,GO:0045471,GO:0045595,GO:0045893,GO:0047485,GO:0050727,GO:0051087,GO:0051591,GO:0051726,GO:0060544,GO:0060546,GO:0061630,GO:0070266,GO:0070424,GO:0098770,GO:1901222,GO:1902443,GO:1902523,GO:1902524,GO:1902527,GO:2000116,GO:2000377" "protein polyubiquitination|response to hypoxia|XY body|placenta development|MyD88-independent toll-like receptor signaling pathway|transcription coactivator activity|ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|cytosol|apoptotic process|cell surface receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|zinc ion binding|cytoplasmic side of plasma membrane|regulation of tumor necrosis factor-mediated signaling pathway|protein deubiquitination|transferase activity|positive regulation of protein ubiquitination|tumor necrosis factor-mediated signaling pathway|regulation of toll-like receptor signaling pathway|CD40 receptor complex|TRIF-dependent toll-like receptor signaling pathway|NIK/NF-kappaB signaling|regulation of RIG-I signaling pathway|regulation of cell population proliferation|identical protein binding|regulation of apoptotic process|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein-containing complex binding|regulation of innate immune response|membrane raft|response to ethanol|regulation of cell differentiation|positive regulation of transcription, DNA-templated|protein N-terminus binding|regulation of inflammatory response|chaperone binding|response to cAMP|regulation of cell cycle|regulation of necroptotic process|negative regulation of necroptotic process|ubiquitin protein ligase activity|necroptotic process|regulation of nucleotide-binding oligomerization domain containing signaling pathway|FBXO family protein binding|regulation of NIK/NF-kappaB signaling|negative regulation of ripoptosome assembly involved in necroptotic process|positive regulation of protein K63-linked ubiquitination|positive regulation of protein K48-linked ubiquitination|positive regulation of protein monoubiquitination|regulation of cysteine-type endopeptidase activity|regulation of reactive oxygen species metabolic process" "hsa01524,hsa04064,hsa04120,hsa04210,hsa04215,hsa04217,hsa04390,hsa04510,hsa04621,hsa04668,hsa05132,hsa05145,hsa05168,hsa05200,hsa05202,hsa05222" Platinum drug resistance|NF-kappa B signaling pathway|Ubiquitin mediated proteolysis|Apoptosis|Apoptosis - multiple species|Necroptosis|Hippo signaling pathway|Focal adhesion|NOD-like receptor signaling pathway|TNF signaling pathway|Salmonella infection|Toxoplasmosis|Herpes simplex virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Small cell lung cancer BIRC3 809.9413562 975.9082219 643.9744905 0.65987198 -0.599741937 0.017041458 0.770503287 11.76206598 7.631580281 330 baculoviral IAP repeat containing 3 "GO:0002756,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0007166,GO:0007249,GO:0010803,GO:0016567,GO:0016579,GO:0016740,GO:0031398,GO:0033209,GO:0034121,GO:0035666,GO:0038061,GO:0039535,GO:0042981,GO:0043027,GO:0043066,GO:0043123,GO:0045088,GO:0046872,GO:0050727,GO:0051726,GO:0060544,GO:0060546,GO:0061630,GO:0070424,GO:2000116" MyD88-independent toll-like receptor signaling pathway|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|apoptotic process|cell surface receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|regulation of tumor necrosis factor-mediated signaling pathway|protein ubiquitination|protein deubiquitination|transferase activity|positive regulation of protein ubiquitination|tumor necrosis factor-mediated signaling pathway|regulation of toll-like receptor signaling pathway|TRIF-dependent toll-like receptor signaling pathway|NIK/NF-kappaB signaling|regulation of RIG-I signaling pathway|regulation of apoptotic process|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|regulation of innate immune response|metal ion binding|regulation of inflammatory response|regulation of cell cycle|regulation of necroptotic process|negative regulation of necroptotic process|ubiquitin protein ligase activity|regulation of nucleotide-binding oligomerization domain containing signaling pathway|regulation of cysteine-type endopeptidase activity "hsa01524,hsa04064,hsa04120,hsa04210,hsa04215,hsa04217,hsa04390,hsa04510,hsa04621,hsa04668,hsa05132,hsa05145,hsa05168,hsa05200,hsa05202,hsa05222" Platinum drug resistance|NF-kappa B signaling pathway|Ubiquitin mediated proteolysis|Apoptosis|Apoptosis - multiple species|Necroptosis|Hippo signaling pathway|Focal adhesion|NOD-like receptor signaling pathway|TNF signaling pathway|Salmonella infection|Toxoplasmosis|Herpes simplex virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Small cell lung cancer BIRC5 1970.591394 1835.290089 2105.8927 1.147444054 0.198423814 0.402209102 1 37.05866777 41.81118738 332 baculoviral IAP repeat containing 5 "GO:0000228,GO:0000775,GO:0000777,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005876,GO:0006468,GO:0006915,GO:0007059,GO:0007605,GO:0008017,GO:0008284,GO:0019221,GO:0019899,GO:0030496,GO:0031267,GO:0031503,GO:0032133,GO:0042802,GO:0042981,GO:0043027,GO:0043066,GO:0045892,GO:0046872,GO:0051087,GO:0051301,GO:0051726" "nuclear chromosome|chromosome, centromeric region|condensed chromosome kinetochore|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|spindle microtubule|protein phosphorylation|apoptotic process|chromosome segregation|sensory perception of sound|microtubule binding|positive regulation of cell population proliferation|cytokine-mediated signaling pathway|enzyme binding|midbody|small GTPase binding|protein-containing complex localization|chromosome passenger complex|identical protein binding|regulation of apoptotic process|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of transcription, DNA-templated|metal ion binding|chaperone binding|cell division|regulation of cell cycle" "hsa01524,hsa04210,hsa04215,hsa04390,hsa05161,hsa05200,hsa05210" Platinum drug resistance|Apoptosis|Apoptosis - multiple species|Hippo signaling pathway|Hepatitis B|Pathways in cancer|Colorectal cancer BIRC6 2328.300656 2533.407804 2123.193507 0.838078064 -0.254843464 0.281018719 1 6.88092617 5.670254473 57448 baculoviral IAP repeat containing 6 "GO:0000922,GO:0004842,GO:0004869,GO:0005515,GO:0005634,GO:0005768,GO:0005802,GO:0005815,GO:0006468,GO:0006511,GO:0006915,GO:0007049,GO:0008284,GO:0010951,GO:0016020,GO:0016567,GO:0030496,GO:0032465,GO:0042127,GO:0043066,GO:0051301,GO:0060711,GO:0061631,GO:0090543,GO:2001237" spindle pole|ubiquitin-protein transferase activity|cysteine-type endopeptidase inhibitor activity|protein binding|nucleus|endosome|trans-Golgi network|microtubule organizing center|protein phosphorylation|ubiquitin-dependent protein catabolic process|apoptotic process|cell cycle|positive regulation of cell population proliferation|negative regulation of endopeptidase activity|membrane|protein ubiquitination|midbody|regulation of cytokinesis|regulation of cell population proliferation|negative regulation of apoptotic process|cell division|labyrinthine layer development|ubiquitin conjugating enzyme activity|Flemming body|negative regulation of extrinsic apoptotic signaling pathway "hsa04120,hsa04215" Ubiquitin mediated proteolysis|Apoptosis - multiple species BIVM 580.6439516 532.6919079 628.5959952 1.180036689 0.238831716 0.368203194 1 7.461624168 8.657650689 54841 "basic, immunoglobulin-like variable motif containing" "GO:0005515,GO:0005615,GO:0005634,GO:0005737" protein binding|extracellular space|nucleus|cytoplasm BLCAP 1456.42572 1306.759837 1606.091602 1.2290641 0.297560159 0.213232046 1 19.7786077 23.90239552 10904 BLCAP apoptosis inducing factor "GO:0005515,GO:0007049,GO:0016021,GO:0030262" protein binding|cell cycle|integral component of membrane|apoptotic nuclear changes BLID 10.52805613 11.44455271 9.61155956 0.839837065 -0.251818634 0.906931683 1 0.697231443 0.575762242 414899 "BH3-like motif containing, cell death inducer" "GO:0003674,GO:0005739,GO:0005829,GO:0006915,GO:0043280" molecular_function|mitochondrion|cytosol|apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process BLM 688.2129319 732.4513734 643.9744905 0.879204428 -0.185729443 0.47149107 1 7.728268804 6.681027577 641 BLM RecQ like helicase "GO:0000079,GO:0000228,GO:0000400,GO:0000403,GO:0000405,GO:0000723,GO:0000724,GO:0000729,GO:0000733,GO:0000781,GO:0000800,GO:0002039,GO:0003677,GO:0003678,GO:0003697,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005657,GO:0005694,GO:0005730,GO:0005737,GO:0005829,GO:0006260,GO:0006268,GO:0006281,GO:0006310,GO:0006974,GO:0007095,GO:0008094,GO:0008270,GO:0009378,GO:0010165,GO:0016363,GO:0016605,GO:0016887,GO:0031297,GO:0032508,GO:0032991,GO:0036310,GO:0042802,GO:0042803,GO:0043138,GO:0044806,GO:0045893,GO:0045910,GO:0048478,GO:0051259,GO:0051260,GO:0051782,GO:0051880,GO:0061749,GO:0061820,GO:0061821,GO:0061849,GO:0071479,GO:0072711,GO:0072757,GO:0090329,GO:0090656,GO:1901796,GO:1905773" "regulation of cyclin-dependent protein serine/threonine kinase activity|nuclear chromosome|four-way junction DNA binding|Y-form DNA binding|bubble DNA binding|telomere maintenance|double-strand break repair via homologous recombination|DNA double-strand break processing|DNA strand renaturation|chromosome, telomeric region|lateral element|p53 binding|DNA binding|DNA helicase activity|single-stranded DNA binding|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|replication fork|chromosome|nucleolus|cytoplasm|cytosol|DNA replication|DNA unwinding involved in DNA replication|DNA repair|DNA recombination|cellular response to DNA damage stimulus|mitotic G2 DNA damage checkpoint|DNA-dependent ATPase activity|zinc ion binding|four-way junction helicase activity|response to X-ray|nuclear matrix|PML body|ATPase activity|replication fork processing|DNA duplex unwinding|protein-containing complex|annealing helicase activity|identical protein binding|protein homodimerization activity|3'-5' DNA helicase activity|G-quadruplex DNA unwinding|positive regulation of transcription, DNA-templated|negative regulation of DNA recombination|replication fork protection|protein complex oligomerization|protein homooligomerization|negative regulation of cell division|G-quadruplex DNA binding|forked DNA-dependent helicase activity|telomeric D-loop disassembly|telomeric D-loop binding|telomeric G-quadruplex DNA binding|cellular response to ionizing radiation|cellular response to hydroxyurea|cellular response to camptothecin|regulation of DNA-dependent DNA replication|t-circle formation|regulation of signal transduction by p53 class mediator|8-hydroxy-2'-deoxyguanosine DNA binding" "hsa03440,hsa03460" Homologous recombination|Fanconi anemia pathway BLMH 750.1131419 767.8254454 732.4008385 0.953863724 -0.068144928 0.792659494 1 17.76221622 16.65922 642 bleomycin hydrolase "GO:0000209,GO:0004177,GO:0004180,GO:0004197,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0008234,GO:0009636,GO:0042493,GO:0042802,GO:0043418,GO:0070062" protein polyubiquitination|aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding|nucleus|cytoplasm|cytosol|proteolysis|cysteine-type peptidase activity|response to toxic substance|response to drug|identical protein binding|homocysteine catabolic process|extracellular exosome BLOC1S1 598.8612553 544.1364606 653.5860501 1.201143642 0.26440869 0.315790124 1 51.67181997 61.02669965 2647 biogenesis of lysosomal organelles complex 1 subunit 1 "GO:0005515,GO:0005615,GO:0005739,GO:0005758,GO:0005759,GO:0005765,GO:0005829,GO:0008089,GO:0009060,GO:0016197,GO:0018394,GO:0031083,GO:0031175,GO:0032418,GO:0032438,GO:0048490,GO:0060155,GO:0099078,GO:1904115" protein binding|extracellular space|mitochondrion|mitochondrial intermembrane space|mitochondrial matrix|lysosomal membrane|cytosol|anterograde axonal transport|aerobic respiration|endosomal transport|peptidyl-lysine acetylation|BLOC-1 complex|neuron projection development|lysosome localization|melanosome organization|anterograde synaptic vesicle transport|platelet dense granule organization|BORC complex|axon cytoplasm BLOC1S2 874.8055208 811.5228285 938.088213 1.15596035 0.209091914 0.40231056 1 14.42687603 16.39783139 282991 biogenesis of lysosomal organelles complex 1 subunit 2 "GO:0000930,GO:0005515,GO:0005739,GO:0005765,GO:0008089,GO:0008625,GO:0016197,GO:0031083,GO:0031175,GO:0032418,GO:0032438,GO:0043015,GO:0048490,GO:0060155,GO:0097345,GO:0099078,GO:1904115" gamma-tubulin complex|protein binding|mitochondrion|lysosomal membrane|anterograde axonal transport|extrinsic apoptotic signaling pathway via death domain receptors|endosomal transport|BLOC-1 complex|neuron projection development|lysosome localization|melanosome organization|gamma-tubulin binding|anterograde synaptic vesicle transport|platelet dense granule organization|mitochondrial outer membrane permeabilization|BORC complex|axon cytoplasm BLOC1S3 224.056935 229.9314681 218.182402 0.948901879 -0.075669182 0.839841286 1 4.791495453 4.470576855 388552 biogenesis of lysosomal organelles complex 1 subunit 3 "GO:0001654,GO:0003674,GO:0005515,GO:0005829,GO:0008089,GO:0008320,GO:0030133,GO:0030168,GO:0031083,GO:0031175,GO:0032402,GO:0032438,GO:0032816,GO:0033299,GO:0035646,GO:0042493,GO:0043473,GO:0048490,GO:0060155,GO:0071806,GO:1904115" eye development|molecular_function|protein binding|cytosol|anterograde axonal transport|protein transmembrane transporter activity|transport vesicle|platelet activation|BLOC-1 complex|neuron projection development|melanosome transport|melanosome organization|positive regulation of natural killer cell activation|secretion of lysosomal enzymes|endosome to melanosome transport|response to drug|pigmentation|anterograde synaptic vesicle transport|platelet dense granule organization|protein transmembrane transport|axon cytoplasm BLOC1S4 363.0622432 333.9728563 392.15163 1.174202102 0.231680745 0.438557235 1 11.95406943 13.80161175 55330 biogenesis of lysosomal organelles complex 1 subunit 4 "GO:0005515,GO:0005737,GO:0005829,GO:0008089,GO:0031083,GO:0031175,GO:0032438,GO:0048490,GO:0050885,GO:0070527,GO:1904115" protein binding|cytoplasm|cytosol|anterograde axonal transport|BLOC-1 complex|neuron projection development|melanosome organization|anterograde synaptic vesicle transport|neuromuscular process controlling balance|platelet aggregation|axon cytoplasm BLOC1S5 509.8706555 453.6204528 566.1208581 1.248005584 0.319624389 0.240663716 1 8.764985463 10.75570562 63915 biogenesis of lysosomal organelles complex 1 subunit 5 "GO:0005515,GO:0008089,GO:0030133,GO:0031083,GO:0031175,GO:0032402,GO:0032438,GO:0035646,GO:0048490,GO:0050942,GO:1904115" protein binding|anterograde axonal transport|transport vesicle|BLOC-1 complex|neuron projection development|melanosome transport|melanosome organization|endosome to melanosome transport|anterograde synaptic vesicle transport|positive regulation of pigment cell differentiation|axon cytoplasm BLOC1S6 910.1204565 830.2502783 989.9906347 1.192400244 0.253868576 0.30664802 1 11.01390291 12.91321788 26258 biogenesis of lysosomal organelles complex 1 subunit 6 "GO:0005515,GO:0005737,GO:0005829,GO:0008089,GO:0016081,GO:0019898,GO:0019905,GO:0030133,GO:0031083,GO:0031175,GO:0031201,GO:0032402,GO:0032438,GO:0035646,GO:0042802,GO:0042803,GO:0046907,GO:0048490,GO:0050942,GO:0051015,GO:0098793,GO:1904115" protein binding|cytoplasm|cytosol|anterograde axonal transport|synaptic vesicle docking|extrinsic component of membrane|syntaxin binding|transport vesicle|BLOC-1 complex|neuron projection development|SNARE complex|melanosome transport|melanosome organization|endosome to melanosome transport|identical protein binding|protein homodimerization activity|intracellular transport|anterograde synaptic vesicle transport|positive regulation of pigment cell differentiation|actin filament binding|presynapse|axon cytoplasm BLVRA 1565.788678 1427.447847 1704.12951 1.193829612 0.255596945 0.283445795 1 54.49232336 63.9659495 644 biliverdin reductase A "GO:0004074,GO:0005515,GO:0005829,GO:0008270,GO:0042167,GO:0055114,GO:0070062,GO:0106276,GO:0106277" biliverdin reductase (NAD(P)+) activity|protein binding|cytosol|zinc ion binding|heme catabolic process|oxidation-reduction process|extracellular exosome|biliberdin reductase NAD+ activity|biliverdin reductase (NADP+) activity hsa00860 Porphyrin and chlorophyll metabolism BLVRB 745.7237735 728.2897178 763.1578291 1.047876704 0.067468975 0.794963396 1 48.64516108 50.121148 645 biliverdin reductase B "GO:0004074,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0042167,GO:0042602,GO:0043231,GO:0055114,GO:0070062,GO:0106276,GO:0106277" biliverdin reductase (NAD(P)+) activity|protein binding|nucleoplasm|cytosol|plasma membrane|heme catabolic process|riboflavin reductase (NADPH) activity|intracellular membrane-bounded organelle|oxidation-reduction process|extracellular exosome|biliberdin reductase NAD+ activity|biliverdin reductase (NADP+) activity "hsa00740,hsa00860" Riboflavin metabolism|Porphyrin and chlorophyll metabolism BLZF1 682.4214585 693.9560597 670.8868573 0.96675697 -0.048774835 0.854956976 1 10.25904694 9.75204075 8548 basic leucine zipper nuclear factor 1 "GO:0000139,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0007030,GO:0019899,GO:0031625,GO:0043001" Golgi membrane|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|Golgi organization|enzyme binding|ubiquitin protein ligase binding|Golgi to plasma membrane protein transport BMERB1 266.9522924 220.5677431 313.3368417 1.420592319 0.50649259 0.122361592 1 5.365221087 7.494251499 89927 bMERB domain containing 1 "GO:0005515,GO:0007026,GO:0015630,GO:0021822" protein binding|negative regulation of microtubule depolymerization|microtubule cytoskeleton|negative regulation of cell motility involved in cerebral cortex radial glia guided migration BMF 75.48975713 101.9605605 49.01895376 0.480763871 -1.056599612 0.041175187 1 1.097508616 0.518813108 90427 Bcl2 modifying factor "GO:0001669,GO:0001844,GO:0005515,GO:0005741,GO:0005829,GO:0005886,GO:0010507,GO:0016459,GO:0031334,GO:0034644,GO:0043065,GO:0043276,GO:0090200,GO:2001244" acrosomal vesicle|protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|protein binding|mitochondrial outer membrane|cytosol|plasma membrane|negative regulation of autophagy|myosin complex|positive regulation of protein-containing complex assembly|cellular response to UV|positive regulation of apoptotic process|anoikis|positive regulation of release of cytochrome c from mitochondria|positive regulation of intrinsic apoptotic signaling pathway hsa05206 MicroRNAs in cancer BMI1 16.01255871 16.64662212 15.3784953 0.923820772 -0.11431511 0.976849093 1 0.250960347 0.227962813 648 "BMI1 proto-oncogene, polycomb ring finger" "GO:0000122,GO:0000151,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006342,GO:0007379,GO:0008270,GO:0010468,GO:0016604,GO:0030097,GO:0031519,GO:0035102,GO:0036353,GO:0045814,GO:0048146,GO:0051443,GO:0070317,GO:0071535,GO:1990841" "negative regulation of transcription by RNA polymerase II|ubiquitin ligase complex|protein binding|nucleus|nucleoplasm|cytosol|chromatin silencing|segment specification|zinc ion binding|regulation of gene expression|nuclear body|hemopoiesis|PcG protein complex|PRC1 complex|histone H2A-K119 monoubiquitination|negative regulation of gene expression, epigenetic|positive regulation of fibroblast proliferation|positive regulation of ubiquitin-protein transferase activity|negative regulation of G0 to G1 transition|RING-like zinc finger domain binding|promoter-specific chromatin binding" "hsa04550,hsa05202,hsa05206" Signaling pathways regulating pluripotency of stem cells|Transcriptional misregulation in cancer|MicroRNAs in cancer chromosome_remodelling_factor BMP1 295.4542337 350.6194785 240.288989 0.685326982 -0.545135606 0.08432907 1 4.727619291 3.185748633 649 bone morphogenetic protein 1 "GO:0001501,GO:0001502,GO:0001503,GO:0004222,GO:0005125,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005794,GO:0006508,GO:0007165,GO:0007275,GO:0008083,GO:0008233,GO:0008237,GO:0008270,GO:0022617,GO:0030154,GO:0031982,GO:0034380,GO:0042802,GO:0061036" skeletal system development|cartilage condensation|ossification|metalloendopeptidase activity|cytokine activity|calcium ion binding|protein binding|extracellular region|extracellular space|Golgi apparatus|proteolysis|signal transduction|multicellular organism development|growth factor activity|peptidase activity|metallopeptidase activity|zinc ion binding|extracellular matrix disassembly|cell differentiation|vesicle|high-density lipoprotein particle assembly|identical protein binding|positive regulation of cartilage development BMP2 137.3006483 160.2237379 114.3775588 0.713861505 -0.486283887 0.246786721 1 2.412086436 1.693082062 650 bone morphogenetic protein 2 "GO:0000122,GO:0000187,GO:0001501,GO:0001649,GO:0001658,GO:0001666,GO:0001701,GO:0001837,GO:0001934,GO:0001938,GO:0002062,GO:0003130,GO:0003176,GO:0003181,GO:0003203,GO:0003210,GO:0003272,GO:0003308,GO:0003331,GO:0004745,GO:0005102,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0006029,GO:0006355,GO:0006468,GO:0006954,GO:0007219,GO:0007267,GO:0007507,GO:0008083,GO:0008285,GO:0009617,GO:0009887,GO:0009986,GO:0010628,GO:0010629,GO:0010718,GO:0010862,GO:0010894,GO:0010922,GO:0019211,GO:0021537,GO:0021978,GO:0030177,GO:0030282,GO:0030335,GO:0030501,GO:0030509,GO:0031648,GO:0032092,GO:0032348,GO:0033690,GO:0035051,GO:0035054,GO:0035630,GO:0039706,GO:0042475,GO:0042482,GO:0042487,GO:0043065,GO:0043231,GO:0043410,GO:0043569,GO:0045165,GO:0045600,GO:0045666,GO:0045669,GO:0045778,GO:0045786,GO:0045892,GO:0045893,GO:0045944,GO:0046332,GO:0048711,GO:0048762,GO:0048839,GO:0051042,GO:0055007,GO:0055008,GO:0055114,GO:0060039,GO:0060128,GO:0060129,GO:0060317,GO:0060389,GO:0060395,GO:0060485,GO:0060804,GO:0061036,GO:0061312,GO:0070374,GO:0070700,GO:0070724,GO:0071407,GO:0071773,GO:0072138,GO:0090090,GO:1900745,GO:1901522,GO:1902895,GO:1905072,GO:1905222,GO:2000065,GO:2000726" "negative regulation of transcription by RNA polymerase II|activation of MAPK activity|skeletal system development|osteoblast differentiation|branching involved in ureteric bud morphogenesis|response to hypoxia|in utero embryonic development|epithelial to mesenchymal transition|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|chondrocyte differentiation|BMP signaling pathway involved in heart induction|aortic valve development|atrioventricular valve morphogenesis|endocardial cushion morphogenesis|cardiac atrium formation|endocardial cushion formation|negative regulation of Wnt signaling pathway involved in heart development|positive regulation of extracellular matrix constituent secretion|retinol dehydrogenase activity|signaling receptor binding|cytokine activity|protein binding|extracellular region|extracellular space|proteoglycan metabolic process|regulation of transcription, DNA-templated|protein phosphorylation|inflammatory response|Notch signaling pathway|cell-cell signaling|heart development|growth factor activity|negative regulation of cell population proliferation|response to bacterium|animal organ morphogenesis|cell surface|positive regulation of gene expression|negative regulation of gene expression|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of steroid biosynthetic process|positive regulation of phosphatase activity|phosphatase activator activity|telencephalon development|telencephalon regionalization|positive regulation of Wnt signaling pathway|bone mineralization|positive regulation of cell migration|positive regulation of bone mineralization|BMP signaling pathway|protein destabilization|positive regulation of protein binding|negative regulation of aldosterone biosynthetic process|positive regulation of osteoblast proliferation|cardiocyte differentiation|embryonic heart tube anterior/posterior pattern specification|bone mineralization involved in bone maturation|co-receptor binding|odontogenesis of dentin-containing tooth|positive regulation of odontogenesis|regulation of odontogenesis of dentin-containing tooth|positive regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of MAPK cascade|negative regulation of insulin-like growth factor receptor signaling pathway|cell fate commitment|positive regulation of fat cell differentiation|positive regulation of neuron differentiation|positive regulation of osteoblast differentiation|positive regulation of ossification|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|SMAD binding|positive regulation of astrocyte differentiation|mesenchymal cell differentiation|inner ear development|negative regulation of calcium-independent cell-cell adhesion|cardiac muscle cell differentiation|cardiac muscle tissue morphogenesis|oxidation-reduction process|pericardium development|corticotropin hormone secreting cell differentiation|thyroid-stimulating hormone-secreting cell differentiation|cardiac epithelial to mesenchymal transition|pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction|mesenchyme development|positive regulation of Wnt signaling pathway by BMP signaling pathway|positive regulation of cartilage development|BMP signaling pathway involved in heart development|positive regulation of ERK1 and ERK2 cascade|BMP receptor binding|BMP receptor complex|cellular response to organic cyclic compound|cellular response to BMP stimulus|mesenchymal cell proliferation involved in ureteric bud development|negative regulation of canonical Wnt signaling pathway|positive regulation of p38MAPK cascade|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|positive regulation of pri-miRNA transcription by RNA polymerase II|cardiac jelly development|atrioventricular canal morphogenesis|negative regulation of cortisol biosynthetic process|negative regulation of cardiac muscle cell differentiation" "hsa04060,hsa04350,hsa04390,hsa05200,hsa05217" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway|Pathways in cancer|Basal cell carcinoma BMP2K 718.5094662 682.511507 754.5074255 1.105486747 0.144681729 0.573548539 1 4.363769585 4.743364838 55589 BMP2 inducible kinase "GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0016607,GO:0019208,GO:0030500,GO:0035612,GO:0045747,GO:0050790,GO:0106310,GO:0106311,GO:2000369" protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|nuclear speck|phosphatase regulator activity|regulation of bone mineralization|AP-2 adaptor complex binding|positive regulation of Notch signaling pathway|regulation of catalytic activity|protein serine kinase activity|protein threonine kinase activity|regulation of clathrin-dependent endocytosis hsa05202 Transcriptional misregulation in cancer BMP3 5.122811487 8.323311061 1.922311912 0.230955193 -2.11431511 0.224307997 1 0.075390328 0.017120425 651 bone morphogenetic protein 3 "GO:0001501,GO:0001649,GO:0005102,GO:0005125,GO:0005615,GO:0007267,GO:0008083,GO:0010862,GO:0051216,GO:0060395,GO:0070062,GO:0070700" skeletal system development|osteoblast differentiation|signaling receptor binding|cytokine activity|extracellular space|cell-cell signaling|growth factor activity|positive regulation of pathway-restricted SMAD protein phosphorylation|cartilage development|SMAD protein signal transduction|extracellular exosome|BMP receptor binding hsa04060 Cytokine-cytokine receptor interaction BMP4 15.89367182 13.52538047 18.26196316 1.350199589 0.433172685 0.689082402 1 0.290472715 0.38563327 652 bone morphogenetic protein 4 "GO:0000122,GO:0000186,GO:0001649,GO:0001657,GO:0001658,GO:0001822,GO:0001823,GO:0001843,GO:0001934,GO:0001938,GO:0001958,GO:0002043,GO:0002062,GO:0002244,GO:0002320,GO:0003014,GO:0003130,GO:0003139,GO:0003148,GO:0003149,GO:0003150,GO:0003180,GO:0003184,GO:0003197,GO:0003198,GO:0003215,GO:0003277,GO:0003279,GO:0003323,GO:0003337,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0007182,GO:0007281,GO:0007492,GO:0007500,GO:0008083,GO:0008201,GO:0008284,GO:0008285,GO:0009791,GO:0009948,GO:0010159,GO:0010453,GO:0010595,GO:0010628,GO:0010629,GO:0010718,GO:0010862,GO:0010942,GO:0021537,GO:0021904,GO:0021978,GO:0021983,GO:0030218,GO:0030224,GO:0030225,GO:0030501,GO:0030509,GO:0030513,GO:0032092,GO:0032331,GO:0032967,GO:0033085,GO:0033088,GO:0034504,GO:0035116,GO:0035990,GO:0035993,GO:0039706,GO:0042056,GO:0042306,GO:0042326,GO:0042475,GO:0042476,GO:0042487,GO:0042733,GO:0043065,GO:0043066,GO:0043401,GO:0043407,GO:0043687,GO:0044267,GO:0045603,GO:0045606,GO:0045662,GO:0045666,GO:0045669,GO:0045778,GO:0045786,GO:0045839,GO:0045843,GO:0045892,GO:0045893,GO:0045944,GO:0048286,GO:0048392,GO:0048661,GO:0048663,GO:0048701,GO:0048745,GO:0048754,GO:0050679,GO:0050680,GO:0050918,GO:0051150,GO:0055007,GO:0055020,GO:0060113,GO:0060197,GO:0060235,GO:0060272,GO:0060363,GO:0060391,GO:0060393,GO:0060395,GO:0060425,GO:0060433,GO:0060438,GO:0060440,GO:0060441,GO:0060442,GO:0060449,GO:0060502,GO:0060503,GO:0060548,GO:0060592,GO:0060684,GO:0060686,GO:0060687,GO:0060976,GO:0061036,GO:0061047,GO:0061149,GO:0061151,GO:0061155,GO:0061312,GO:0061626,GO:0070244,GO:0070374,GO:0070700,GO:0071773,GO:0071893,GO:0072015,GO:0072097,GO:0072101,GO:0072104,GO:0072125,GO:0072138,GO:0072161,GO:0072192,GO:0072193,GO:0072198,GO:0072200,GO:0072205,GO:0090184,GO:0090191,GO:0090194,GO:1901964,GO:1902893,GO:1902894,GO:1903800,GO:1905072,GO:1905312,GO:2000005,GO:2000007,GO:2000137,GO:2001237" "negative regulation of transcription by RNA polymerase II|activation of MAPKK activity|osteoblast differentiation|ureteric bud development|branching involved in ureteric bud morphogenesis|kidney development|mesonephros development|neural tube closure|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|endochondral ossification|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|chondrocyte differentiation|hematopoietic progenitor cell differentiation|lymphoid progenitor cell differentiation|renal system process|BMP signaling pathway involved in heart induction|secondary heart field specification|outflow tract septum morphogenesis|membranous septum morphogenesis|muscular septum morphogenesis|aortic valve morphogenesis|pulmonary valve morphogenesis|endocardial cushion development|epithelial to mesenchymal transition involved in endocardial cushion formation|cardiac right ventricle morphogenesis|apoptotic process involved in endocardial cushion morphogenesis|cardiac septum development|type B pancreatic cell development|mesenchymal to epithelial transition involved in metanephros morphogenesis|cytokine activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|common-partner SMAD protein phosphorylation|germ cell development|endoderm development|mesodermal cell fate determination|growth factor activity|heparin binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|post-embryonic development|anterior/posterior axis specification|specification of animal organ position|regulation of cell fate commitment|positive regulation of endothelial cell migration|positive regulation of gene expression|negative regulation of gene expression|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of cell death|telencephalon development|dorsal/ventral neural tube patterning|telencephalon regionalization|pituitary gland development|erythrocyte differentiation|monocyte differentiation|macrophage differentiation|positive regulation of bone mineralization|BMP signaling pathway|positive regulation of BMP signaling pathway|positive regulation of protein binding|negative regulation of chondrocyte differentiation|positive regulation of collagen biosynthetic process|negative regulation of T cell differentiation in thymus|negative regulation of immature T cell proliferation in thymus|protein localization to nucleus|embryonic hindlimb morphogenesis|tendon cell differentiation|deltoid tuberosity development|co-receptor binding|chemoattractant activity|regulation of protein import into nucleus|negative regulation of phosphorylation|odontogenesis of dentin-containing tooth|odontogenesis|regulation of odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|positive regulation of apoptotic process|negative regulation of apoptotic process|steroid hormone mediated signaling pathway|negative regulation of MAP kinase activity|post-translational protein modification|cellular protein metabolic process|positive regulation of endothelial cell differentiation|positive regulation of epidermal cell differentiation|negative regulation of myoblast differentiation|positive regulation of neuron differentiation|positive regulation of osteoblast differentiation|positive regulation of ossification|negative regulation of cell cycle|negative regulation of mitotic nuclear division|negative regulation of striated muscle tissue development|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|lung alveolus development|intermediate mesodermal cell differentiation|positive regulation of smooth muscle cell proliferation|neuron fate commitment|embryonic cranial skeleton morphogenesis|smooth muscle tissue development|branching morphogenesis of an epithelial tube|positive regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|positive chemotaxis|regulation of smooth muscle cell differentiation|cardiac muscle cell differentiation|positive regulation of cardiac muscle fiber development|inner ear receptor cell differentiation|cloacal septation|lens induction in camera-type eye|embryonic skeletal joint morphogenesis|cranial suture morphogenesis|positive regulation of SMAD protein signal transduction|regulation of pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction|lung morphogenesis|bronchus development|trachea development|trachea formation|epithelial tube branching involved in lung morphogenesis|branching involved in prostate gland morphogenesis|bud elongation involved in lung branching|epithelial cell proliferation involved in lung morphogenesis|bud dilation involved in lung branching|negative regulation of cell death|mammary gland formation|epithelial-mesenchymal cell signaling|negative regulation of prostatic bud formation|regulation of branching involved in prostate gland morphogenesis|coronary vasculature development|positive regulation of cartilage development|positive regulation of branching involved in lung morphogenesis|BMP signaling pathway involved in ureter morphogenesis|BMP signaling pathway involved in renal system segmentation|pulmonary artery endothelial tube morphogenesis|BMP signaling pathway involved in heart development|pharyngeal arch artery morphogenesis|negative regulation of thymocyte apoptotic process|positive regulation of ERK1 and ERK2 cascade|BMP receptor binding|cellular response to BMP stimulus|BMP signaling pathway involved in nephric duct formation|glomerular visceral epithelial cell development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|glomerular capillary formation|negative regulation of glomerular mesangial cell proliferation|mesenchymal cell proliferation involved in ureteric bud development|mesenchymal cell differentiation involved in kidney development|ureter epithelial cell differentiation|ureter smooth muscle cell differentiation|mesenchymal cell proliferation involved in ureter development|negative regulation of mesenchymal cell proliferation involved in ureter development|metanephric collecting duct development|positive regulation of kidney development|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of glomerulus development|positive regulation of cell proliferation involved in outflow tract morphogenesis|regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of production of miRNAs involved in gene silencing by miRNA|cardiac jelly development|positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of extrinsic apoptotic signaling pathway" "hsa04060,hsa04350,hsa04390,hsa04550,hsa04919,hsa05200,hsa05217,hsa05418" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Thyroid hormone signaling pathway|Pathways in cancer|Basal cell carcinoma|Fluid shear stress and atherosclerosis BMP6 64.6496997 69.70773014 59.59166927 0.854878923 -0.22620799 0.698152515 1 0.983132516 0.826395319 654 bone morphogenetic protein 6 "GO:0000122,GO:0001501,GO:0001649,GO:0001654,GO:0001822,GO:0001938,GO:0001958,GO:0003323,GO:0005125,GO:0005615,GO:0005737,GO:0006879,GO:0006954,GO:0006955,GO:0008083,GO:0008284,GO:0010628,GO:0010862,GO:0014823,GO:0030501,GO:0030509,GO:0030539,GO:0031666,GO:0031982,GO:0032026,GO:0032332,GO:0032349,GO:0032526,GO:0043117,GO:0045603,GO:0045666,GO:0045669,GO:0045944,GO:0046982,GO:0050679,GO:0050714,GO:0050731,GO:0051216,GO:0051384,GO:0060391,GO:0060395,GO:0060586,GO:0070700,GO:0071260,GO:0071281,GO:0071773,GO:1903392,GO:2000048,GO:2000860" negative regulation of transcription by RNA polymerase II|skeletal system development|osteoblast differentiation|eye development|kidney development|positive regulation of endothelial cell proliferation|endochondral ossification|type B pancreatic cell development|cytokine activity|extracellular space|cytoplasm|cellular iron ion homeostasis|inflammatory response|immune response|growth factor activity|positive regulation of cell population proliferation|positive regulation of gene expression|positive regulation of pathway-restricted SMAD protein phosphorylation|response to activity|positive regulation of bone mineralization|BMP signaling pathway|male genitalia development|positive regulation of lipopolysaccharide-mediated signaling pathway|vesicle|response to magnesium ion|positive regulation of chondrocyte differentiation|positive regulation of aldosterone biosynthetic process|response to retinoic acid|positive regulation of vascular permeability|positive regulation of endothelial cell differentiation|positive regulation of neuron differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|positive regulation of epithelial cell proliferation|positive regulation of protein secretion|positive regulation of peptidyl-tyrosine phosphorylation|cartilage development|response to glucocorticoid|positive regulation of SMAD protein signal transduction|SMAD protein signal transduction|multicellular organismal iron ion homeostasis|BMP receptor binding|cellular response to mechanical stimulus|cellular response to iron ion|cellular response to BMP stimulus|negative regulation of adherens junction organization|negative regulation of cell-cell adhesion mediated by cadherin|positive regulation of aldosterone secretion "hsa04060,hsa04350,hsa04390,hsa04913" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway|Ovarian steroidogenesis BMP8B 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.027948814 0.008462546 656 bone morphogenetic protein 8b "GO:0001501,GO:0001503,GO:0005125,GO:0005615,GO:0008083,GO:0010862,GO:0030154,GO:0030509,GO:0051216,GO:0060395,GO:0070700" skeletal system development|ossification|cytokine activity|extracellular space|growth factor activity|positive regulation of pathway-restricted SMAD protein phosphorylation|cell differentiation|BMP signaling pathway|cartilage development|SMAD protein signal transduction|BMP receptor binding "hsa04060,hsa04350,hsa04390,hsa04714" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway|Thermogenesis BMPER 192.8942084 143.5771158 242.2113009 1.686977061 0.754440357 0.040899515 1 1.372706339 2.2769736 168667 BMP binding endothelial regulator "GO:0001568,GO:0001657,GO:0002043,GO:0005615,GO:0010594,GO:0030514,GO:0031012,GO:0042118,GO:0045765,GO:0048839,GO:0060393,GO:0070374,GO:1903672" blood vessel development|ureteric bud development|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|extracellular space|regulation of endothelial cell migration|negative regulation of BMP signaling pathway|extracellular matrix|endothelial cell activation|regulation of angiogenesis|inner ear development|regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of ERK1 and ERK2 cascade|positive regulation of sprouting angiogenesis BMPR1A 1827.338913 1935.169822 1719.508005 0.888556646 -0.170464344 0.472594601 1 15.41439652 13.46737101 657 bone morphogenetic protein receptor type 1A "GO:0001701,GO:0001707,GO:0001756,GO:0001880,GO:0002053,GO:0002062,GO:0003148,GO:0003151,GO:0003161,GO:0003183,GO:0003186,GO:0003203,GO:0003215,GO:0003222,GO:0003223,GO:0003272,GO:0004674,GO:0004675,GO:0005025,GO:0005515,GO:0005524,GO:0005886,GO:0005901,GO:0006468,GO:0006955,GO:0007179,GO:0007398,GO:0009897,GO:0009950,GO:0009953,GO:0010665,GO:0010862,GO:0014032,GO:0014912,GO:0016021,GO:0019827,GO:0021983,GO:0021998,GO:0030324,GO:0030425,GO:0030501,GO:0030509,GO:0035137,GO:0035912,GO:0042475,GO:0042733,GO:0042803,GO:0043025,GO:0043235,GO:0045669,GO:0045944,GO:0046332,GO:0046872,GO:0048352,GO:0048368,GO:0048378,GO:0048382,GO:0048568,GO:0048589,GO:0050679,GO:0050768,GO:0060021,GO:0060043,GO:0060045,GO:0060391,GO:0060914,GO:0061312,GO:0061626,GO:0071363,GO:0071773,GO:0098821,GO:1902895,GO:1904414,GO:1904707,GO:1905285,GO:1905292,GO:1990712,GO:2000772" "in utero embryonic development|mesoderm formation|somitogenesis|Mullerian duct regression|positive regulation of mesenchymal cell proliferation|chondrocyte differentiation|outflow tract septum morphogenesis|outflow tract morphogenesis|cardiac conduction system development|mitral valve morphogenesis|tricuspid valve morphogenesis|endocardial cushion morphogenesis|cardiac right ventricle morphogenesis|ventricular trabecula myocardium morphogenesis|ventricular compact myocardium morphogenesis|endocardial cushion formation|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|transforming growth factor beta receptor activity, type I|protein binding|ATP binding|plasma membrane|caveola|protein phosphorylation|immune response|transforming growth factor beta receptor signaling pathway|ectoderm development|external side of plasma membrane|dorsal/ventral axis specification|dorsal/ventral pattern formation|regulation of cardiac muscle cell apoptotic process|positive regulation of pathway-restricted SMAD protein phosphorylation|neural crest cell development|negative regulation of smooth muscle cell migration|integral component of membrane|stem cell population maintenance|pituitary gland development|neural plate mediolateral regionalization|lung development|dendrite|positive regulation of bone mineralization|BMP signaling pathway|hindlimb morphogenesis|dorsal aorta morphogenesis|odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|protein homodimerization activity|neuronal cell body|receptor complex|positive regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|SMAD binding|metal ion binding|paraxial mesoderm structural organization|lateral mesoderm development|regulation of lateral mesodermal cell fate specification|mesendoderm development|embryonic organ development|developmental growth|positive regulation of epithelial cell proliferation|negative regulation of neurogenesis|roof of mouth development|regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle cell proliferation|positive regulation of SMAD protein signal transduction|heart formation|BMP signaling pathway involved in heart development|pharyngeal arch artery morphogenesis|cellular response to growth factor stimulus|cellular response to BMP stimulus|BMP receptor activity|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of cardiac ventricle development|positive regulation of vascular associated smooth muscle cell proliferation|fibrous ring of heart morphogenesis|regulation of neural crest cell differentiation|HFE-transferrin receptor complex|regulation of cellular senescence" "hsa04060,hsa04350,hsa04390,hsa04550,hsa05418" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Fluid shear stress and atherosclerosis BMPR1B 63.81749147 47.8590386 79.77594435 1.666894001 0.737162365 0.180841135 1 0.387756024 0.635532428 658 bone morphogenetic protein receptor type 1B "GO:0001501,GO:0001502,GO:0001550,GO:0001654,GO:0002063,GO:0004674,GO:0004675,GO:0005025,GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0006468,GO:0006954,GO:0009953,GO:0030166,GO:0030425,GO:0030501,GO:0030509,GO:0031290,GO:0032332,GO:0035108,GO:0042698,GO:0043025,GO:0043235,GO:0045597,GO:0045669,GO:0045944,GO:0046332,GO:0046872,GO:0060041,GO:0060350,GO:0061036,GO:0071363,GO:0071773,GO:1902043,GO:1902731,GO:1990712" "skeletal system development|cartilage condensation|ovarian cumulus expansion|eye development|chondrocyte development|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|transforming growth factor beta receptor activity, type I|protein binding|ATP binding|plasma membrane|integral component of plasma membrane|protein phosphorylation|inflammatory response|dorsal/ventral pattern formation|proteoglycan biosynthetic process|dendrite|positive regulation of bone mineralization|BMP signaling pathway|retinal ganglion cell axon guidance|positive regulation of chondrocyte differentiation|limb morphogenesis|ovulation cycle|neuronal cell body|receptor complex|positive regulation of cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|SMAD binding|metal ion binding|retina development in camera-type eye|endochondral bone morphogenesis|positive regulation of cartilage development|cellular response to growth factor stimulus|cellular response to BMP stimulus|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of chondrocyte proliferation|HFE-transferrin receptor complex" "hsa04060,hsa04350,hsa04360,hsa04390,hsa04550,hsa05418" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Axon guidance|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Fluid shear stress and atherosclerosis BMPR2 2403.761459 2508.437871 2299.085047 0.916540558 -0.125729371 0.595524525 1 11.07559517 9.981365061 659 bone morphogenetic protein receptor type 2 "GO:0001568,GO:0001707,GO:0001893,GO:0001935,GO:0001938,GO:0001946,GO:0001974,GO:0002063,GO:0003085,GO:0003148,GO:0003151,GO:0003176,GO:0003177,GO:0003181,GO:0003183,GO:0003186,GO:0003197,GO:0003252,GO:0004674,GO:0005024,GO:0005515,GO:0005524,GO:0005615,GO:0005654,GO:0005737,GO:0005886,GO:0005887,GO:0005901,GO:0005912,GO:0006468,GO:0007178,GO:0007420,GO:0009267,GO:0009925,GO:0009952,GO:0009986,GO:0010595,GO:0010634,GO:0010862,GO:0014069,GO:0014916,GO:0016324,GO:0016362,GO:0019838,GO:0030166,GO:0030308,GO:0030425,GO:0030501,GO:0030509,GO:0030513,GO:0032924,GO:0036122,GO:0042127,GO:0043025,GO:0043235,GO:0044214,GO:0045296,GO:0045669,GO:0045778,GO:0045906,GO:0045944,GO:0046872,GO:0048286,GO:0048738,GO:0048842,GO:0060173,GO:0060350,GO:0060412,GO:0060413,GO:0060836,GO:0060840,GO:0060841,GO:0061036,GO:0061298,GO:0061626,GO:0071363,GO:0071773,GO:0072577,GO:0098821,GO:1902731,GO:1905314,GO:1990782,GO:2000279" "blood vessel development|mesoderm formation|maternal placenta development|endothelial cell proliferation|positive regulation of endothelial cell proliferation|lymphangiogenesis|blood vessel remodeling|chondrocyte development|negative regulation of systemic arterial blood pressure|outflow tract septum morphogenesis|outflow tract morphogenesis|aortic valve development|pulmonary valve development|atrioventricular valve morphogenesis|mitral valve morphogenesis|tricuspid valve morphogenesis|endocardial cushion development|negative regulation of cell proliferation involved in heart valve morphogenesis|protein serine/threonine kinase activity|transforming growth factor beta-activated receptor activity|protein binding|ATP binding|extracellular space|nucleoplasm|cytoplasm|plasma membrane|integral component of plasma membrane|caveola|adherens junction|protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|brain development|cellular response to starvation|basal plasma membrane|anterior/posterior pattern specification|cell surface|positive regulation of endothelial cell migration|positive regulation of epithelial cell migration|positive regulation of pathway-restricted SMAD protein phosphorylation|postsynaptic density|regulation of lung blood pressure|apical plasma membrane|activin receptor activity, type II|growth factor binding|proteoglycan biosynthetic process|negative regulation of cell growth|dendrite|positive regulation of bone mineralization|BMP signaling pathway|positive regulation of BMP signaling pathway|activin receptor signaling pathway|BMP binding|regulation of cell population proliferation|neuronal cell body|receptor complex|spanning component of plasma membrane|cadherin binding|positive regulation of osteoblast differentiation|positive regulation of ossification|negative regulation of vasoconstriction|positive regulation of transcription by RNA polymerase II|metal ion binding|lung alveolus development|cardiac muscle tissue development|positive regulation of axon extension involved in axon guidance|limb development|endochondral bone morphogenesis|ventricular septum morphogenesis|atrial septum morphogenesis|lymphatic endothelial cell differentiation|artery development|venous blood vessel development|positive regulation of cartilage development|retina vasculature development in camera-type eye|pharyngeal arch artery morphogenesis|cellular response to growth factor stimulus|cellular response to BMP stimulus|endothelial cell apoptotic process|BMP receptor activity|negative regulation of chondrocyte proliferation|semi-lunar valve development|protein tyrosine kinase binding|negative regulation of DNA biosynthetic process" "hsa04060,hsa04350,hsa04360,hsa04390,hsa04550,hsa05206,hsa05418" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Axon guidance|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|MicroRNAs in cancer|Fluid shear stress and atherosclerosis BMS1 1927.636286 1893.553266 1961.719306 1.035999008 0.051022622 0.831288241 1 22.29328428 22.70934313 9790 BMS1 ribosome biogenesis factor "GO:0000462,GO:0000479,GO:0003723,GO:0003924,GO:0005524,GO:0005525,GO:0005654,GO:0005694,GO:0005730,GO:0006364,GO:0030686,GO:0034511" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|GTPase activity|ATP binding|GTP binding|nucleoplasm|chromosome|nucleolus|rRNA processing|90S preribosome|U3 snoRNA binding" hsa03008 Ribosome biogenesis in eukaryotes BMT2 160.7351128 144.6175297 176.8526959 1.222899439 0.290305773 0.46831417 1 1.958876082 2.355422872 154743 base methyltransferase of 25S rRNA 2 homolog "GO:0005730,GO:0016433,GO:0031167,GO:0034198,GO:0140007,GO:1904047,GO:1904262,GO:1990130" nucleolus|rRNA (adenine) methyltransferase activity|rRNA methylation|cellular response to amino acid starvation|KICSTOR complex|S-adenosyl-L-methionine binding|negative regulation of TORC1 signaling|GATOR1 complex BNC1 1368.578715 1359.820945 1377.336485 1.01288077 0.018464359 0.941891749 1 14.39618024 14.33761055 646 basonuclin 1 "GO:0000182,GO:0000976,GO:0001216,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006355,GO:0006356,GO:0007283,GO:0008284,GO:0008544,GO:0030154,GO:0043231,GO:0045943,GO:0046872,GO:1900195" "rDNA binding|transcription regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity|nucleus|nucleoplasm|nucleolus|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase I|spermatogenesis|positive regulation of cell population proliferation|epidermis development|cell differentiation|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase I|metal ion binding|positive regulation of oocyte maturation" BNC2 386.397328 366.2256867 406.5689694 1.110159621 0.150767125 0.610697111 1 1.50611018 1.64404367 54796 basonuclin 2 "GO:0000976,GO:0003416,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0043586,GO:0046872,GO:0060021,GO:0060485" "transcription regulatory region sequence-specific DNA binding|endochondral bone growth|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|tongue development|metal ion binding|roof of mouth development|mesenchyme development" BNIP1 294.3251155 270.5076095 318.1426214 1.176094906 0.234004484 0.463521011 1 9.741223985 11.26489315 662 BCL2 interacting protein 1 "GO:0005484,GO:0005515,GO:0005635,GO:0005737,GO:0005783,GO:0005789,GO:0006890,GO:0006915,GO:0007029,GO:0014823,GO:0016032,GO:0016320,GO:0030137,GO:0030176,GO:0031201,GO:0031966,GO:0042594,GO:0043066,GO:0043231,GO:0090649,GO:0097194" "SNAP receptor activity|protein binding|nuclear envelope|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|apoptotic process|endoplasmic reticulum organization|response to activity|viral process|endoplasmic reticulum membrane fusion|COPI-coated vesicle|integral component of endoplasmic reticulum membrane|SNARE complex|mitochondrial membrane|response to starvation|negative regulation of apoptotic process|intracellular membrane-bounded organelle|response to oxygen-glucose deprivation|execution phase of apoptosis" hsa04130 SNARE interactions in vesicular transport BNIP2 1993.203097 1873.785403 2112.620791 1.127461442 0.173078095 0.465084579 1 15.76797273 17.48029417 663 BCL2 interacting protein 2 "GO:0004309,GO:0005096,GO:0005509,GO:0005515,GO:0005635,GO:0005737,GO:0005829,GO:0006798,GO:0006915,GO:0043066,GO:0043231,GO:0043547,GO:0048471,GO:0051149" exopolyphosphatase activity|GTPase activator activity|calcium ion binding|protein binding|nuclear envelope|cytoplasm|cytosol|polyphosphate catabolic process|apoptotic process|negative regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of GTPase activity|perinuclear region of cytoplasm|positive regulation of muscle cell differentiation BNIP3 2061.183473 1728.127459 2394.239486 1.385453066 0.470357838 0.04693256 1 59.80997816 81.47730217 664 BCL2 interacting protein 3 "GO:0000422,GO:0001666,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005783,GO:0006915,GO:0008219,GO:0009617,GO:0010508,GO:0010637,GO:0010659,GO:0010666,GO:0010917,GO:0010940,GO:0014069,GO:0016032,GO:0016239,GO:0021987,GO:0030425,GO:0031307,GO:0031966,GO:0035694,GO:0042802,GO:0042803,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043243,GO:0043653,GO:0045837,GO:0046902,GO:0048102,GO:0048678,GO:0048709,GO:0050873,GO:0051020,GO:0051402,GO:0051561,GO:0051607,GO:0055093,GO:0060548,GO:0070301,GO:0071260,GO:0071279,GO:0071456,GO:0072593,GO:0090141,GO:0090200,GO:0090649,GO:0097345,GO:0140507,GO:1901998,GO:1902109,GO:1903599,GO:1903715,GO:1990144,GO:2000378" autophagy of mitochondrion|response to hypoxia|protein binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|apoptotic process|cell death|response to bacterium|positive regulation of autophagy|negative regulation of mitochondrial fusion|cardiac muscle cell apoptotic process|positive regulation of cardiac muscle cell apoptotic process|negative regulation of mitochondrial membrane potential|positive regulation of necrotic cell death|postsynaptic density|viral process|positive regulation of macroautophagy|cerebral cortex development|dendrite|integral component of mitochondrial outer membrane|mitochondrial membrane|mitochondrial protein catabolic process|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of programmed cell death|positive regulation of programmed cell death|positive regulation of protein-containing complex disassembly|mitochondrial fragmentation involved in apoptotic process|negative regulation of membrane potential|regulation of mitochondrial membrane permeability|autophagic cell death|response to axon injury|oligodendrocyte differentiation|brown fat cell differentiation|GTPase binding|neuron apoptotic process|positive regulation of mitochondrial calcium ion concentration|defense response to virus|response to hyperoxia|negative regulation of cell death|cellular response to hydrogen peroxide|cellular response to mechanical stimulus|cellular response to cobalt ion|cellular response to hypoxia|reactive oxygen species metabolic process|positive regulation of mitochondrial fission|positive regulation of release of cytochrome c from mitochondria|response to oxygen-glucose deprivation|mitochondrial outer membrane permeabilization|granzyme-mediated programmed cell death signaling pathway|toxin transport|negative regulation of mitochondrial membrane permeability involved in apoptotic process|positive regulation of autophagy of mitochondrion|regulation of aerobic respiration|intrinsic apoptotic signaling pathway in response to hypoxia|negative regulation of reactive oxygen species metabolic process "hsa04068,hsa04137,hsa04140,hsa05131,hsa05134" FoxO signaling pathway|Mitophagy - animal|Autophagy - animal|Shigellosis|Legionellosis BNIP3L 3342.462999 2675.944506 4008.981492 1.498155692 0.58318756 0.014129524 0.708244576 40.14906947 59.14303557 665 BCL2 interacting protein 3 like "GO:0005515,GO:0005521,GO:0005634,GO:0005635,GO:0005739,GO:0005741,GO:0005783,GO:0005829,GO:0010917,GO:0016021,GO:0016032,GO:0016239,GO:0016607,GO:0031224,GO:0035694,GO:0042802,GO:0042803,GO:0042981,GO:0043065,GO:0043066,GO:0043067,GO:0051607,GO:0060548,GO:0071456,GO:0097345,GO:1903146,GO:1903214" protein binding|lamin binding|nucleus|nuclear envelope|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|cytosol|negative regulation of mitochondrial membrane potential|integral component of membrane|viral process|positive regulation of macroautophagy|nuclear speck|intrinsic component of membrane|mitochondrial protein catabolic process|identical protein binding|protein homodimerization activity|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of programmed cell death|defense response to virus|negative regulation of cell death|cellular response to hypoxia|mitochondrial outer membrane permeabilization|regulation of autophagy of mitochondrion|regulation of protein targeting to mitochondrion hsa04137 Mitophagy - animal BNIPL 7.966650391 7.282897178 8.650403604 1.187769564 0.248254969 0.952730603 1 0.15559441 0.181717755 149428 BCL2 interacting protein like "GO:0004309,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006798,GO:0006915,GO:0008285,GO:0040009,GO:0042802" exopolyphosphatase activity|protein binding|nucleus|cytoplasm|cytosol|polyphosphate catabolic process|apoptotic process|negative regulation of cell population proliferation|regulation of growth rate|identical protein binding BOC 5.484502575 5.202069413 5.766935736 1.108584926 0.148719296 1 1 0.050413089 0.054951995 91653 "BOC cell adhesion associated, oncogene regulated" "GO:0005515,GO:0005886,GO:0005887,GO:0007155,GO:0007224,GO:0007411,GO:0044295,GO:0045663,GO:0051149" protein binding|plasma membrane|integral component of plasma membrane|cell adhesion|smoothened signaling pathway|axon guidance|axonal growth cone|positive regulation of myoblast differentiation|positive regulation of muscle cell differentiation "hsa04340,hsa04360" Hedgehog signaling pathway|Axon guidance BOD1 1137.917605 1120.525752 1155.309459 1.03104231 0.044103536 0.859470348 1 25.52300466 25.87494681 91272 biorientation of chromosomes in cell division 1 "GO:0000922,GO:0000940,GO:0004864,GO:0005737,GO:0005813,GO:0005876,GO:0007080,GO:0032515,GO:0051301,GO:0051721,GO:0071459,GO:0071962,GO:1990758" "spindle pole|condensed chromosome outer kinetochore|protein phosphatase inhibitor activity|cytoplasm|centrosome|spindle microtubule|mitotic metaphase plate congression|negative regulation of phosphoprotein phosphatase activity|cell division|protein phosphatase 2A binding|protein localization to chromosome, centromeric region|mitotic sister chromatid cohesion, centromeric|mitotic sister chromatid biorientation" BOD1L1 2433.784392 2640.570434 2226.99835 0.843377749 -0.245749135 0.29856395 1 13.085931 10.85170411 259282 biorientation of chromosomes in cell division 1 like 1 "GO:0000922,GO:0000940,GO:0004864,GO:0005515,GO:0005654,GO:0005813,GO:0005876,GO:0006281,GO:0006974,GO:0031297,GO:0032515,GO:0051721" spindle pole|condensed chromosome outer kinetochore|protein phosphatase inhibitor activity|protein binding|nucleoplasm|centrosome|spindle microtubule|DNA repair|cellular response to DNA damage stimulus|replication fork processing|negative regulation of phosphoprotein phosphatase activity|protein phosphatase 2A binding BOK 1043.96271 1025.848088 1062.077331 1.035316382 0.050071708 0.841577448 1 18.78134718 19.11925676 666 BCL2 family apoptosis regulator BOK "GO:0001836,GO:0005102,GO:0005515,GO:0005634,GO:0005640,GO:0005737,GO:0005739,GO:0005741,GO:0005743,GO:0005783,GO:0005789,GO:0005794,GO:0006915,GO:0006919,GO:0006921,GO:0007420,GO:0008584,GO:0008630,GO:0008635,GO:0010506,GO:0016021,GO:0031625,GO:0031901,GO:0031966,GO:0032588,GO:0033106,GO:0042803,GO:0043065,GO:0043524,GO:0044877,GO:0046982,GO:0048709,GO:0051259,GO:0051400,GO:0051402,GO:0051480,GO:0051902,GO:0055038,GO:0060546,GO:0072332,GO:0097192,GO:1900119,GO:1901029,GO:1901030,GO:1901382,GO:1902237,GO:1903899,GO:1904708,GO:2001244" release of cytochrome c from mitochondria|signaling receptor binding|protein binding|nucleus|nuclear outer membrane|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular component disassembly involved in execution phase of apoptosis|brain development|male gonad development|intrinsic apoptotic signaling pathway in response to DNA damage|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|regulation of autophagy|integral component of membrane|ubiquitin protein ligase binding|early endosome membrane|mitochondrial membrane|trans-Golgi network membrane|cis-Golgi network membrane|protein homodimerization activity|positive regulation of apoptotic process|negative regulation of neuron apoptotic process|protein-containing complex binding|protein heterodimerization activity|oligodendrocyte differentiation|protein complex oligomerization|BH domain binding|neuron apoptotic process|regulation of cytosolic calcium ion concentration|negative regulation of mitochondrial depolarization|recycling endosome membrane|negative regulation of necroptotic process|intrinsic apoptotic signaling pathway by p53 class mediator|extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of execution phase of apoptosis|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|regulation of chorionic trophoblast cell proliferation|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of PERK-mediated unfolded protein response|regulation of granulosa cell apoptotic process|positive regulation of intrinsic apoptotic signaling pathway hsa04215 Apoptosis - multiple species BOLA1 48.7610583 43.69738307 53.82473354 1.231761029 0.300722389 0.639838995 1 2.089649661 2.530877466 51027 bolA family member 1 "GO:0005515,GO:0005739" protein binding|mitochondrion BOLA2-SMG1P6 81.90584753 81.15228285 82.65941222 1.01857162 0.026547426 0.985481449 1 2.102402031 2.105612827 107282092 BOLA2-SMG1P6 readthrough BOLA2B 20.65479222 24.96993318 16.33965125 0.654373047 -0.611814769 0.486795858 1 3.55359851 2.286467014 654483 bolA family member 2B "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006879,GO:0035722,GO:0044571,GO:0051536,GO:0097428" protein binding|nucleus|cytoplasm|cytosol|cellular iron ion homeostasis|interleukin-12-mediated signaling pathway|[2Fe-2S] cluster assembly|iron-sulfur cluster binding|protein maturation by iron-sulfur cluster transfer BOLA3 160.6111955 153.9812546 167.2411363 1.08611361 0.11917502 0.776181661 1 14.80666046 15.81260971 388962 bolA family member 3 "GO:0003674,GO:0005515,GO:0005739,GO:0005829,GO:0008150,GO:0016604" molecular_function|protein binding|mitochondrion|cytosol|biological_process|nuclear body BOP1 1069.135818 1068.505057 1069.766579 1.001180642 0.001702301 0.998860313 1 23.48605893 23.12031616 23246 BOP1 ribosomal biogenesis factor "GO:0000027,GO:0000448,GO:0000463,GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0006364,GO:0008283,GO:0030687,GO:0042254,GO:0043021,GO:0051726,GO:0070545,GO:1901796,GO:1990904" "ribosomal large subunit assembly|cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|rRNA processing|cell population proliferation|preribosome, large subunit precursor|ribosome biogenesis|ribonucleoprotein complex binding|regulation of cell cycle|PeBoW complex|regulation of signal transduction by p53 class mediator|ribonucleoprotein complex" BORA 699.9694859 776.1487565 623.7902154 0.803699304 -0.315272262 0.218605513 1 15.00783791 11.85995118 79866 BORA aurora kinase A activator "GO:0000086,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007088,GO:0019901,GO:0032147,GO:0032880,GO:0051301,GO:0060236" G2/M transition of mitotic cell cycle|protein binding|nucleus|cytoplasm|cytosol|regulation of mitotic nuclear division|protein kinase binding|activation of protein kinase activity|regulation of protein localization|cell division|regulation of mitotic spindle organization BORCS5 240.753247 239.295193 242.2113009 1.012186237 0.017474763 0.972650734 1 2.080942585 2.071055342 118426 BLOC-1 related complex subunit 5 "GO:0005515,GO:0005873,GO:0005886,GO:0030672,GO:0031224,GO:0032418,GO:0043231,GO:0072384,GO:0098574,GO:0099078,GO:1903744" protein binding|plus-end kinesin complex|plasma membrane|synaptic vesicle membrane|intrinsic component of membrane|lysosome localization|intracellular membrane-bounded organelle|organelle transport along microtubule|cytoplasmic side of lysosomal membrane|BORC complex|positive regulation of anterograde synaptic vesicle transport BORCS6 146.4762893 148.7791852 144.1733934 0.969042768 -0.045367756 0.929280562 1 4.324657773 4.120651337 54785 BLOC-1 related complex subunit 6 "GO:0005515,GO:0005765,GO:0032418,GO:0042802,GO:0099078" protein binding|lysosomal membrane|lysosome localization|identical protein binding|BORC complex BORCS7 156.8407992 168.547049 145.1345494 0.861092201 -0.215760373 0.597117274 1 5.81450952 4.9230463 119032 BLOC-1 related complex subunit 7 "GO:0005515,GO:0005765,GO:0099078" protein binding|lysosomal membrane|BORC complex BORCS8 45.95684836 45.77821084 46.13548589 1.007804478 0.011215772 1 1 1.446476599 1.433371861 729991 BLOC-1 related complex subunit 8 "GO:0005515,GO:0005765,GO:0007507,GO:0099078" protein binding|lysosomal membrane|heart development|BORC complex BPGM 353.4009938 357.9023756 348.899612 0.974845756 -0.036754127 0.912060614 1 7.674002407 7.3557848 669 bisphosphoglycerate mutase "GO:0004082,GO:0004619,GO:0005515,GO:0005829,GO:0005975,GO:0007585,GO:0016787,GO:0048821,GO:0061621,GO:0070062" bisphosphoglycerate mutase activity|phosphoglycerate mutase activity|protein binding|cytosol|carbohydrate metabolic process|respiratory gaseous exchange by respiratory system|hydrolase activity|erythrocyte development|canonical glycolysis|extracellular exosome "hsa00010,hsa00260" "Glycolysis / Gluconeogenesis|Glycine, serine and threonine metabolism" BPHL 317.9376031 310.043337 325.8318691 1.05092363 0.071657833 0.825925332 1 6.693544928 6.916693297 670 biphenyl hydrolase like "GO:0005739,GO:0005741,GO:0006520,GO:0006805,GO:0009636,GO:0047658" mitochondrion|mitochondrial outer membrane|cellular amino acid metabolic process|xenobiotic metabolic process|response to toxic substance|alpha-amino-acid esterase activity BPNT1 843.0477452 810.4824146 875.6130759 1.080360363 0.111512616 0.65866232 1 11.53131348 12.2495067 10380 "3'(2'), 5'-bisphosphate nucleotidase 1" "GO:0005829,GO:0006139,GO:0007399,GO:0008441,GO:0046854,GO:0046855,GO:0046872,GO:0050427" "cytosol|nucleobase-containing compound metabolic process|nervous system development|3'(2'),5'-bisphosphate nucleotidase activity|phosphatidylinositol phosphorylation|inositol phosphate dephosphorylation|metal ion binding|3'-phosphoadenosine 5'-phosphosulfate metabolic process" hsa00920 Sulfur metabolism BPNT2 6399.384766 5942.844098 6855.925434 1.153643831 0.206197884 0.396314845 1 43.90346996 49.80142542 54928 "3'(2'), 5'-bisphosphate nucleotidase 2" "GO:0001501,GO:0001958,GO:0002063,GO:0005654,GO:0005794,GO:0005796,GO:0005829,GO:0008254,GO:0008441,GO:0009791,GO:0012505,GO:0016020,GO:0016021,GO:0016604,GO:0030204,GO:0032588,GO:0042733,GO:0046854,GO:0046855,GO:0046872,GO:0050427,GO:0097657" "skeletal system development|endochondral ossification|chondrocyte development|nucleoplasm|Golgi apparatus|Golgi lumen|cytosol|3'-nucleotidase activity|3'(2'),5'-bisphosphate nucleotidase activity|post-embryonic development|endomembrane system|membrane|integral component of membrane|nuclear body|chondroitin sulfate metabolic process|trans-Golgi network membrane|embryonic digit morphogenesis|phosphatidylinositol phosphorylation|inositol phosphate dephosphorylation|metal ion binding|3'-phosphoadenosine 5'-phosphosulfate metabolic process|3',5'-nucleotide bisphosphate phosphatase activity" "hsa00920,hsa04070" Sulfur metabolism|Phosphatidylinositol signaling system BPTF 2423.489079 2647.853331 2199.124827 0.830531209 -0.267893714 0.257093797 1 10.81600197 8.832708394 2186 bromodomain PHD finger transcription factor "GO:0000122,GO:0000785,GO:0000978,GO:0001892,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006338,GO:0006357,GO:0007420,GO:0007492,GO:0008094,GO:0008134,GO:0009611,GO:0009952,GO:0016589,GO:0030425,GO:0035064,GO:0042766,GO:0043565,GO:0044297,GO:0045944,GO:0046872,GO:0048471,GO:0070062,GO:1990090" negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|embryonic placenta development|protein binding|nucleus|nucleoplasm|cytoplasm|chromatin remodeling|regulation of transcription by RNA polymerase II|brain development|endoderm development|DNA-dependent ATPase activity|transcription factor binding|response to wounding|anterior/posterior pattern specification|NURF complex|dendrite|methylated histone binding|nucleosome mobilization|sequence-specific DNA binding|cell body|positive regulation of transcription by RNA polymerase II|metal ion binding|perinuclear region of cytoplasm|extracellular exosome|cellular response to nerve growth factor stimulus chromosome_remodelling_factor BRAF 1070.111451 1131.970304 1008.252598 0.890705873 -0.166978989 0.495714288 1 3.646696527 3.193780889 673 "B-Raf proto-oncogene, serine/threonine kinase" "GO:0000165,GO:0000186,GO:0004672,GO:0004674,GO:0005509,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0005886,GO:0006468,GO:0007173,GO:0009887,GO:0010628,GO:0010828,GO:0031267,GO:0033138,GO:0042802,GO:0043066,GO:0043231,GO:0070374,GO:0070413,GO:0071277,GO:0090150,GO:0097110,GO:0106310,GO:0106311" MAPK cascade|activation of MAPKK activity|protein kinase activity|protein serine/threonine kinase activity|calcium ion binding|protein binding|ATP binding|nucleus|cytosol|plasma membrane|protein phosphorylation|epidermal growth factor receptor signaling pathway|animal organ morphogenesis|positive regulation of gene expression|positive regulation of glucose transmembrane transport|small GTPase binding|positive regulation of peptidyl-serine phosphorylation|identical protein binding|negative regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of ERK1 and ERK2 cascade|trehalose metabolism in response to stress|cellular response to calcium ion|establishment of protein localization to membrane|scaffold protein binding|protein serine kinase activity|protein threonine kinase activity "hsa01521,hsa01522,hsa04010,hsa04012,hsa04015,hsa04024,hsa04062,hsa04068,hsa04150,hsa04270,hsa04510,hsa04650,hsa04720,hsa04722,hsa04726,hsa04730,hsa04810,hsa04910,hsa04914,hsa04928,hsa04934,hsa05010,hsa05022,hsa05034,hsa05160,hsa05161,hsa05200,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|mTOR signaling pathway|Vascular smooth muscle contraction|Focal adhesion|Natural killer cell mediated cytotoxicity|Long-term potentiation|Neurotrophin signaling pathway|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|Hepatitis C|Hepatitis B|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer" BRAP 611.7620189 630.4908129 593.0332248 0.940589796 -0.088362414 0.740682454 1 7.984844777 7.384786081 8315 BRCA1 associated protein "GO:0000151,GO:0000165,GO:0003676,GO:0004842,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0007265,GO:0008139,GO:0008270,GO:0009968,GO:0016567,GO:0031965,GO:0042802,GO:0061630" ubiquitin ligase complex|MAPK cascade|nucleic acid binding|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytoplasm|cytosol|Ras protein signal transduction|nuclear localization sequence binding|zinc ion binding|negative regulation of signal transduction|protein ubiquitination|nuclear membrane|identical protein binding|ubiquitin protein ligase activity hsa04014 Ras signaling pathway BRAT1 789.2827623 761.5829621 816.9825626 1.072742699 0.101304083 0.691185672 1 10.88491777 11.48132204 221927 BRCA1 associated ATM activator 1 "GO:0001934,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006006,GO:0006915,GO:0006974,GO:0008283,GO:0010212,GO:0016020,GO:0016477,GO:0030307,GO:0051646" positive regulation of protein phosphorylation|protein binding|nucleus|nucleoplasm|cytoplasm|glucose metabolic process|apoptotic process|cellular response to DNA damage stimulus|cell population proliferation|response to ionizing radiation|membrane|cell migration|positive regulation of cell growth|mitochondrion localization BRCA1 1608.513002 1842.572986 1374.453017 0.745942238 -0.422864175 0.075550712 1 13.75118637 10.08594385 672 BRCA1 DNA repair associated "GO:0000151,GO:0000724,GO:0000729,GO:0000800,GO:0000976,GO:0003677,GO:0003684,GO:0003713,GO:0003723,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005886,GO:0006260,GO:0006301,GO:0006302,GO:0006303,GO:0006349,GO:0006357,GO:0006359,GO:0006633,GO:0006915,GO:0006974,GO:0006978,GO:0007059,GO:0007098,GO:0008270,GO:0008274,GO:0008630,GO:0009048,GO:0010212,GO:0010575,GO:0010628,GO:0015631,GO:0016567,GO:0016579,GO:0016604,GO:0019899,GO:0031398,GO:0031436,GO:0031625,GO:0032991,GO:0033147,GO:0035066,GO:0035067,GO:0042127,GO:0042802,GO:0042981,GO:0043009,GO:0043627,GO:0044030,GO:0044818,GO:0045717,GO:0045739,GO:0045766,GO:0045892,GO:0045893,GO:0045944,GO:0046600,GO:0051571,GO:0051572,GO:0051573,GO:0051574,GO:0051865,GO:0070063,GO:0070317,GO:0070512,GO:0070531,GO:0071158,GO:0071356,GO:0071681,GO:0072425,GO:0085020,GO:1901796,GO:1902042,GO:1990904,GO:2000378,GO:2000617,GO:2000620" "ubiquitin ligase complex|double-strand break repair via homologous recombination|DNA double-strand break processing|lateral element|transcription regulatory region sequence-specific DNA binding|DNA binding|damaged DNA binding|transcription coactivator activity|RNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|plasma membrane|DNA replication|postreplication repair|double-strand break repair|double-strand break repair via nonhomologous end joining|regulation of gene expression by genetic imprinting|regulation of transcription by RNA polymerase II|regulation of transcription by RNA polymerase III|fatty acid biosynthetic process|apoptotic process|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|chromosome segregation|centrosome cycle|zinc ion binding|gamma-tubulin ring complex|intrinsic apoptotic signaling pathway in response to DNA damage|dosage compensation by inactivation of X chromosome|response to ionizing radiation|positive regulation of vascular endothelial growth factor production|positive regulation of gene expression|tubulin binding|protein ubiquitination|protein deubiquitination|nuclear body|enzyme binding|positive regulation of protein ubiquitination|BRCA1-BARD1 complex|ubiquitin protein ligase binding|protein-containing complex|negative regulation of intracellular estrogen receptor signaling pathway|positive regulation of histone acetylation|negative regulation of histone acetylation|regulation of cell population proliferation|identical protein binding|regulation of apoptotic process|chordate embryonic development|response to estrogen|regulation of DNA methylation|mitotic G2/M transition checkpoint|negative regulation of fatty acid biosynthetic process|positive regulation of DNA repair|positive regulation of angiogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of centriole replication|positive regulation of histone H3-K4 methylation|negative regulation of histone H3-K4 methylation|negative regulation of histone H3-K9 methylation|positive regulation of histone H3-K9 methylation|protein autoubiquitination|RNA polymerase binding|negative regulation of G0 to G1 transition|positive regulation of histone H4-K20 methylation|BRCA1-A complex|positive regulation of cell cycle arrest|cellular response to tumor necrosis factor|cellular response to indole-3-methanol|signal transduction involved in G2 DNA damage checkpoint|protein K6-linked ubiquitination|regulation of signal transduction by p53 class mediator|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|ribonucleoprotein complex|negative regulation of reactive oxygen species metabolic process|positive regulation of histone H3-K9 acetylation|positive regulation of histone H4-K16 acetylation" "hsa01524,hsa03440,hsa03460,hsa04120,hsa04151,hsa05206,hsa05224" Platinum drug resistance|Homologous recombination|Fanconi anemia pathway|Ubiquitin mediated proteolysis|PI3K-Akt signaling pathway|MicroRNAs in cancer|Breast cancer other BRCA2 738.072926 931.170425 544.975427 0.585258522 -0.772854057 0.002429771 0.313463325 4.157173679 2.392308008 675 BRCA2 DNA repair associated "GO:0000722,GO:0000724,GO:0000781,GO:0000800,GO:0001556,GO:0001833,GO:0002020,GO:0003697,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0006289,GO:0006302,GO:0006355,GO:0006978,GO:0007141,GO:0007283,GO:0007420,GO:0007569,GO:0008022,GO:0008585,GO:0010165,GO:0010225,GO:0010332,GO:0010484,GO:0010485,GO:0030097,GO:0030141,GO:0032465,GO:0032991,GO:0033593,GO:0033600,GO:0042771,GO:0042802,GO:0043015,GO:0043966,GO:0043967,GO:0045893,GO:0045931,GO:0048478,GO:0051298,GO:0070200,GO:1990426" "telomere maintenance via recombination|double-strand break repair via homologous recombination|chromosome, telomeric region|lateral element|oocyte maturation|inner cell mass cell proliferation|protease binding|single-stranded DNA binding|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|centrosome|cytosol|nucleotide-excision repair|double-strand break repair|regulation of transcription, DNA-templated|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|male meiosis I|spermatogenesis|brain development|cell aging|protein C-terminus binding|female gonad development|response to X-ray|response to UV-C|response to gamma radiation|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|hemopoiesis|secretory granule|regulation of cytokinesis|protein-containing complex|BRCA2-MAGE-D1 complex|negative regulation of mammary gland epithelial cell proliferation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|identical protein binding|gamma-tubulin binding|histone H3 acetylation|histone H4 acetylation|positive regulation of transcription, DNA-templated|positive regulation of mitotic cell cycle|replication fork protection|centrosome duplication|establishment of protein localization to telomere|mitotic recombination-dependent replication fork processing" "hsa03440,hsa03460,hsa05200,hsa05212,hsa05224" Homologous recombination|Fanconi anemia pathway|Pathways in cancer|Pancreatic cancer|Breast cancer BRCC3 672.3242905 706.4410263 638.2075548 0.90341236 -0.146543443 0.572547797 1 12.77149702 11.34485666 79184 BRCA1/BRCA2-containing complex subunit 3 "GO:0000151,GO:0000152,GO:0000922,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006302,GO:0006303,GO:0007049,GO:0008237,GO:0010165,GO:0010212,GO:0016579,GO:0018215,GO:0030234,GO:0031593,GO:0045739,GO:0046872,GO:0050790,GO:0051301,GO:0061578,GO:0070122,GO:0070531,GO:0070536,GO:0070537,GO:0070552,GO:0072425" ubiquitin ligase complex|nuclear ubiquitin ligase complex|spindle pole|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|double-strand break repair|double-strand break repair via nonhomologous end joining|cell cycle|metallopeptidase activity|response to X-ray|response to ionizing radiation|protein deubiquitination|protein phosphopantetheinylation|enzyme regulator activity|polyubiquitin modification-dependent protein binding|positive regulation of DNA repair|metal ion binding|regulation of catalytic activity|cell division|Lys63-specific deubiquitinase activity|isopeptidase activity|BRCA1-A complex|protein K63-linked deubiquitination|histone H2A K63-linked deubiquitination|BRISC complex|signal transduction involved in G2 DNA damage checkpoint "hsa03440,hsa04621" Homologous recombination|NOD-like receptor signaling pathway BRD1 731.4750108 707.4814402 755.4685814 1.067828127 0.094679456 0.713865079 1 3.092046857 3.246523878 23774 bromodomain containing 1 "GO:0005515,GO:0005634,GO:0005694,GO:0016607,GO:0030425,GO:0035902,GO:0036409,GO:0042393,GO:0043204,GO:0043249,GO:0043966,GO:0043972,GO:0043994,GO:0044154,GO:0045648,GO:0046872,GO:0051602,GO:0070776" protein binding|nucleus|chromosome|nuclear speck|dendrite|response to immobilization stress|histone H3-K14 acetyltransferase complex|histone binding|perikaryon|erythrocyte maturation|histone H3 acetylation|histone H3-K23 acetylation|histone acetyltransferase activity (H3-K23 specific)|histone H3-K14 acetylation|positive regulation of erythrocyte differentiation|metal ion binding|response to electrical stimulus|MOZ/MORF histone acetyltransferase complex BRD2 3257.606445 3059.857229 3455.355662 1.129253885 0.175369877 0.459643333 1 29.869939 33.16630632 6046 bromodomain containing 2 "GO:0001843,GO:0003682,GO:0004674,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006334,GO:0006357,GO:0006468,GO:0007283,GO:0016032,GO:0016607,GO:0070577" neural tube closure|chromatin binding|protein serine/threonine kinase activity|protein binding|nucleus|nucleoplasm|cytoplasm|nucleosome assembly|regulation of transcription by RNA polymerase II|protein phosphorylation|spermatogenesis|viral process|nuclear speck|lysine-acetylated histone binding other BRD3 1165.10173 1241.213762 1088.989698 0.877358704 -0.188761292 0.437552365 1 10.47458843 9.036189609 8019 bromodomain containing 3 "GO:0003682,GO:0005515,GO:0005634,GO:0006325,GO:0006357,GO:0070577" chromatin binding|protein binding|nucleus|chromatin organization|regulation of transcription by RNA polymerase II|lysine-acetylated histone binding chromosome_remodelling_factor BRD3OS 802.4118532 778.2295842 826.5941222 1.062146877 0.08698328 0.733216385 1 7.30951823 7.633865581 266655 BRD3 opposite strand BRD4 1219.357352 1265.143281 1173.571422 0.927619377 -0.108395138 0.655977358 1 6.457998248 5.89032033 23476 bromodomain containing 4 "GO:0000083,GO:0000794,GO:0002039,GO:0003682,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0006468,GO:0006974,GO:0008353,GO:0010971,GO:0016032,GO:0019899,GO:0032968,GO:0043123,GO:0045893,GO:0045944,GO:0050727,GO:0070577,GO:0099122,GO:0106140,GO:1901407,GO:2001255" "regulation of transcription involved in G1/S transition of mitotic cell cycle|condensed nuclear chromosome|p53 binding|chromatin binding|transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|nucleoplasm|chromatin organization|protein phosphorylation|cellular response to DNA damage stimulus|RNA polymerase II CTD heptapeptide repeat kinase activity|positive regulation of G2/M transition of mitotic cell cycle|viral process|enzyme binding|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of inflammatory response|lysine-acetylated histone binding|RNA polymerase II C-terminal domain binding|P-TEFb complex binding|regulation of phosphorylation of RNA polymerase II C-terminal domain|positive regulation of histone H3-K36 trimethylation" chromosome_remodelling_factor BRD7 1843.526308 1716.682906 1970.36971 1.147777322 0.198842775 0.401831715 1 14.81264537 16.71711938 29117 bromodomain containing 7 "GO:0000976,GO:0002039,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0007049,GO:0008134,GO:0008285,GO:0016055,GO:0035066,GO:0042393,GO:0045892,GO:0045893,GO:0070577,GO:1901796,GO:2000134" "transcription regulatory region sequence-specific DNA binding|p53 binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|cell cycle|transcription factor binding|negative regulation of cell population proliferation|Wnt signaling pathway|positive regulation of histone acetylation|histone binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|lysine-acetylated histone binding|regulation of signal transduction by p53 class mediator|negative regulation of G1/S transition of mitotic cell cycle" hsa05225 Hepatocellular carcinoma chromosome_remodelling_factor BRD8 1197.012991 1258.900798 1135.125184 0.901679613 -0.149313193 0.53889284 1 14.62137581 12.96318349 10902 bromodomain containing 8 "GO:0000812,GO:0005515,GO:0005654,GO:0005739,GO:0007166,GO:0016573,GO:0030374,GO:0035267,GO:0040008,GO:0043967,GO:0043968,GO:0045944,GO:0046966,GO:0097067" Swr1 complex|protein binding|nucleoplasm|mitochondrion|cell surface receptor signaling pathway|histone acetylation|nuclear receptor coactivator activity|NuA4 histone acetyltransferase complex|regulation of growth|histone H4 acetylation|histone H2A acetylation|positive regulation of transcription by RNA polymerase II|thyroid hormone receptor binding|cellular response to thyroid hormone stimulus BRD9 993.1258542 965.5040831 1020.747625 1.057217306 0.080271946 0.747306371 1 6.887739392 7.159985597 65980 bromodomain containing 9 "GO:0003676,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0006357,GO:0008150,GO:0016514,GO:0070577" nucleic acid binding|protein binding|nucleus|nucleoplasm|chromatin organization|regulation of transcription by RNA polymerase II|biological_process|SWI/SNF complex|lysine-acetylated histone binding BRF1 447.9949832 456.7416945 439.2482719 0.961699528 -0.056341884 0.848351594 1 4.134237581 3.909363122 2972 BRF1 RNA polymerase III transcription initiation factor subunit "GO:0000126,GO:0000995,GO:0001006,GO:0005515,GO:0005634,GO:0005654,GO:0006352,GO:0006383,GO:0006384,GO:0009303,GO:0009304,GO:0017025,GO:0045945,GO:0046872,GO:0070897,GO:0097550" "transcription factor TFIIIB complex|RNA polymerase III general transcription initiation factor activity|RNA polymerase III type 3 promoter sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|DNA-templated transcription, initiation|transcription by RNA polymerase III|transcription initiation from RNA polymerase III promoter|rRNA transcription|tRNA transcription|TBP-class protein binding|positive regulation of transcription by RNA polymerase III|metal ion binding|transcription preinitiation complex assembly|transcription preinitiation complex" other BRF2 172.9823056 163.3449796 182.6196316 1.11799966 0.16091975 0.68581059 1 3.405242713 3.743354199 55290 BRF2 RNA polymerase III transcription initiation factor subunit "GO:0000126,GO:0001006,GO:0005634,GO:0005654,GO:0006352,GO:0006359,GO:0017025,GO:0034599,GO:0046872,GO:0070897,GO:0097550" "transcription factor TFIIIB complex|RNA polymerase III type 3 promoter sequence-specific DNA binding|nucleus|nucleoplasm|DNA-templated transcription, initiation|regulation of transcription by RNA polymerase III|TBP-class protein binding|cellular response to oxidative stress|metal ion binding|transcription preinitiation complex assembly|transcription preinitiation complex" other BRI3 1883.686653 1736.45077 2030.922535 1.169582559 0.225993703 0.340288808 1 53.50530378 61.53169746 25798 brain protein I3 "GO:0005515,GO:0005634,GO:0005886,GO:0016021,GO:0035577,GO:0042802,GO:0043312,GO:0048471" protein binding|nucleus|plasma membrane|integral component of membrane|azurophil granule membrane|identical protein binding|neutrophil degranulation|perinuclear region of cytoplasm BRI3BP 657.0848038 659.6224016 654.547206 0.992305908 -0.011143152 0.97220118 1 4.639888657 4.527144059 140707 BRI3 binding protein "GO:0005515,GO:0005739,GO:0005741,GO:0016021" protein binding|mitochondrion|mitochondrial outer membrane|integral component of membrane BRICD5 23.49863112 23.9295193 23.06774294 0.963986892 -0.052914565 1 1 1.546094993 1.465475226 283870 BRICHOS domain containing 5 "GO:0005515,GO:0005615,GO:0016021,GO:0042127" protein binding|extracellular space|integral component of membrane|regulation of cell population proliferation BRIP1 1364.856779 1552.297513 1177.416046 0.758498958 -0.398780896 0.096405924 1 6.966888005 5.195950395 83990 BRCA1 interacting protein C-terminal helicase 1 "GO:0000077,GO:0003677,GO:0003678,GO:0003682,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006260,GO:0006289,GO:0006302,GO:0006357,GO:0007284,GO:0007286,GO:0008285,GO:0009636,GO:0010629,GO:0010705,GO:0031965,GO:0032508,GO:0046872,GO:0051026,GO:0051539,GO:0071295,GO:0071456,GO:0072520,GO:1901796,GO:1904385,GO:1990918" "DNA damage checkpoint|DNA binding|DNA helicase activity|chromatin binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|DNA replication|nucleotide-excision repair|double-strand break repair|regulation of transcription by RNA polymerase II|spermatogonial cell division|spermatid development|negative regulation of cell population proliferation|response to toxic substance|negative regulation of gene expression|meiotic DNA double-strand break processing involved in reciprocal meiotic recombination|nuclear membrane|DNA duplex unwinding|metal ion binding|chiasma assembly|4 iron, 4 sulfur cluster binding|cellular response to vitamin|cellular response to hypoxia|seminiferous tubule development|regulation of signal transduction by p53 class mediator|cellular response to angiotensin|double-strand break repair involved in meiotic recombination" "hsa03440,hsa03460" Homologous recombination|Fanconi anemia pathway BRIX1 1040.86159 969.6657386 1112.057441 1.146846173 0.197671895 0.420688371 1 32.52625915 36.67840705 55299 biogenesis of ribosomes BRX1 "GO:0000027,GO:0003723,GO:0005515,GO:0005694,GO:0005730" ribosomal large subunit assembly|RNA binding|protein binding|chromosome|nucleolus BRK1 2250.504815 1992.392585 2508.617045 1.259097762 0.332390305 0.159768738 1 92.46115688 114.4695442 55845 BRICK1 subunit of SCAR/WAVE actin nucleating complex "GO:0001701,GO:0005515,GO:0005829,GO:0005856,GO:0007015,GO:0008064,GO:0008284,GO:0010592,GO:0016601,GO:0030027,GO:0031209,GO:0031267,GO:0031334,GO:0038096,GO:0042802,GO:0044877,GO:0048010,GO:0048870,GO:0070062,GO:2000601" in utero embryonic development|protein binding|cytosol|cytoskeleton|actin filament organization|regulation of actin polymerization or depolymerization|positive regulation of cell population proliferation|positive regulation of lamellipodium assembly|Rac protein signal transduction|lamellipodium|SCAR complex|small GTPase binding|positive regulation of protein-containing complex assembly|Fc-gamma receptor signaling pathway involved in phagocytosis|identical protein binding|protein-containing complex binding|vascular endothelial growth factor receptor signaling pathway|cell motility|extracellular exosome|positive regulation of Arp2/3 complex-mediated actin nucleation "hsa04810,hsa05130,hsa05132" Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Salmonella infection BRME1 20.77870953 15.60620824 25.95121081 1.662877389 0.733681797 0.397164732 1 0.15234583 0.24909326 79173 break repair meiotic recombinase recruitment factor 1 "GO:0003674,GO:0005515,GO:0005575,GO:0005694,GO:0007275,GO:0007283,GO:1990918" molecular_function|protein binding|cellular_component|chromosome|multicellular organism development|spermatogenesis|double-strand break repair involved in meiotic recombination BRMS1 664.996734 703.3197847 626.6736833 0.891022401 -0.166466392 0.521563708 1 26.24817081 22.99634656 25855 BRMS1 transcriptional repressor and anoikis regulator "GO:0000122,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006915,GO:0016575,GO:0032088,GO:0042826,GO:0042981,GO:0045892,GO:0051059,GO:0070822,GO:0090312,GO:2000210" "negative regulation of transcription by RNA polymerase II|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|apoptotic process|histone deacetylation|negative regulation of NF-kappaB transcription factor activity|histone deacetylase binding|regulation of apoptotic process|negative regulation of transcription, DNA-templated|NF-kappaB binding|Sin3-type complex|positive regulation of protein deacetylation|positive regulation of anoikis" BRMS1L 306.0866999 301.720026 310.4533738 1.028945204 0.041166155 0.906002577 1 4.262107795 4.312090385 84312 BRMS1 like transcriptional repressor "GO:0000122,GO:0004407,GO:0005515,GO:0016575,GO:0040008,GO:0042826,GO:0070822" negative regulation of transcription by RNA polymerase II|histone deacetylase activity|protein binding|histone deacetylation|regulation of growth|histone deacetylase binding|Sin3-type complex BROX 1298.652718 1265.143281 1332.162155 1.052973347 0.074468919 0.759483794 1 14.18155255 14.68291672 148362 BRO1 domain and CAAX motif containing "GO:0005515,GO:0016020,GO:0070062" protein binding|membrane|extracellular exosome BRPF1 552.5024726 601.3592242 503.6457209 0.837512257 -0.255817791 0.339621489 1 6.361434399 5.238626108 7862 bromodomain and PHD finger containing 1 "GO:0000123,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0005886,GO:0010698,GO:0042393,GO:0043966,GO:0043972,GO:0043994,GO:0044154,GO:0045893,GO:0046872,GO:0050790,GO:0070776,GO:1901796" "histone acetyltransferase complex|DNA binding|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|cytosol|plasma membrane|acetyltransferase activator activity|histone binding|histone H3 acetylation|histone H3-K23 acetylation|histone acetyltransferase activity (H3-K23 specific)|histone H3-K14 acetylation|positive regulation of transcription, DNA-templated|metal ion binding|regulation of catalytic activity|MOZ/MORF histone acetyltransferase complex|regulation of signal transduction by p53 class mediator" BRPF3 743.478785 833.37152 653.5860501 0.784267322 -0.350582606 0.167459955 1 6.467283169 4.98720448 27154 bromodomain and PHD finger containing 3 "GO:0000123,GO:0002576,GO:0005515,GO:0005576,GO:0005829,GO:0042393,GO:0043966,GO:0043972,GO:0043994,GO:0044154,GO:0045740,GO:0046872,GO:0070776" histone acetyltransferase complex|platelet degranulation|protein binding|extracellular region|cytosol|histone binding|histone H3 acetylation|histone H3-K23 acetylation|histone acetyltransferase activity (H3-K23 specific)|histone H3-K14 acetylation|positive regulation of DNA replication|metal ion binding|MOZ/MORF histone acetyltransferase complex BRSK1 222.9127255 187.2744989 258.5509522 1.38059882 0.465294156 0.18301213 1 2.94649051 3.999850167 84446 BR serine/threonine kinase 1 "GO:0000086,GO:0000287,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0006468,GO:0006974,GO:0007095,GO:0007269,GO:0007409,GO:0008021,GO:0008306,GO:0009411,GO:0010212,GO:0010975,GO:0018105,GO:0019901,GO:0030010,GO:0030054,GO:0030182,GO:0035556,GO:0042149,GO:0043015,GO:0048156,GO:0048167,GO:0048786,GO:0050321,GO:0050770,GO:0051298,GO:0090176,GO:0099504,GO:0106310,GO:0106311,GO:0150034,GO:2000807" G2/M transition of mitotic cell cycle|magnesium ion binding|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|protein phosphorylation|cellular response to DNA damage stimulus|mitotic G2 DNA damage checkpoint|neurotransmitter secretion|axonogenesis|synaptic vesicle|associative learning|response to UV|response to ionizing radiation|regulation of neuron projection development|peptidyl-serine phosphorylation|protein kinase binding|establishment of cell polarity|cell junction|neuron differentiation|intracellular signal transduction|cellular response to glucose starvation|gamma-tubulin binding|tau protein binding|regulation of synaptic plasticity|presynaptic active zone|tau-protein kinase activity|regulation of axonogenesis|centrosome duplication|microtubule cytoskeleton organization involved in establishment of planar polarity|synaptic vesicle cycle|protein serine kinase activity|protein threonine kinase activity|distal axon|regulation of synaptic vesicle clustering BRSK2 22.41858828 20.80827765 24.0288989 1.154775965 0.207612985 0.849653793 1 0.182798277 0.207558734 9024 BR serine/threonine kinase 2 "GO:0000086,GO:0000287,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0005783,GO:0005813,GO:0006468,GO:0006887,GO:0007409,GO:0010975,GO:0018105,GO:0019901,GO:0030010,GO:0030182,GO:0031532,GO:0035556,GO:0036503,GO:0042149,GO:0043462,GO:0048156,GO:0048471,GO:0050321,GO:0050770,GO:0051117,GO:0051301,GO:0060590,GO:0061178,GO:0070059,GO:0090176,GO:0106310,GO:0106311,GO:0150034,GO:1904152,GO:2000807" "G2/M transition of mitotic cell cycle|magnesium ion binding|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|endoplasmic reticulum|centrosome|protein phosphorylation|exocytosis|axonogenesis|regulation of neuron projection development|peptidyl-serine phosphorylation|protein kinase binding|establishment of cell polarity|neuron differentiation|actin cytoskeleton reorganization|intracellular signal transduction|ERAD pathway|cellular response to glucose starvation|regulation of ATPase activity|tau protein binding|perinuclear region of cytoplasm|tau-protein kinase activity|regulation of axonogenesis|ATPase binding|cell division|ATPase regulator activity|regulation of insulin secretion involved in cellular response to glucose stimulus|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|microtubule cytoskeleton organization involved in establishment of planar polarity|protein serine kinase activity|protein threonine kinase activity|distal axon|regulation of retrograde protein transport, ER to cytosol|regulation of synaptic vesicle clustering" BRWD1 1368.569268 1283.870731 1453.267805 1.131942469 0.178800635 0.456856094 1 2.906869512 3.235348513 54014 bromodomain and WD repeat domain containing 1 "GO:0003674,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006325,GO:0006357,GO:0007010,GO:0008360,GO:0038111" molecular_function|nucleus|nucleoplasm|nucleolus|cytosol|chromatin organization|regulation of transcription by RNA polymerase II|cytoskeleton organization|regulation of cell shape|interleukin-7-mediated signaling pathway BRWD3 1297.032347 1310.921492 1283.143201 0.978810103 -0.030899102 0.901056307 1 5.421688675 5.21800148 254065 bromodomain and WD repeat domain containing 3 "GO:0005634,GO:0006357,GO:0007010,GO:0008360" nucleus|regulation of transcription by RNA polymerase II|cytoskeleton organization|regulation of cell shape BSCL2 452.9592788 460.90335 445.0152076 0.965528256 -0.050609615 0.864084505 1 11.04515702 10.48595671 26580 "BSCL2 lipid droplet biogenesis associated, seipin" "GO:0005515,GO:0005543,GO:0005789,GO:0005811,GO:0016042,GO:0019915,GO:0030176,GO:0034389,GO:0045444,GO:0050995,GO:0120162,GO:0140042" protein binding|phospholipid binding|endoplasmic reticulum membrane|lipid droplet|lipid catabolic process|lipid storage|integral component of endoplasmic reticulum membrane|lipid droplet organization|fat cell differentiation|negative regulation of lipid catabolic process|positive regulation of cold-induced thermogenesis|lipid droplet formation BSDC1 1212.302782 1180.869757 1243.735807 1.053237074 0.07483021 0.759740883 1 12.35460666 12.79458605 55108 BSD domain containing 1 GO:0005515 protein binding BSG 6967.125496 6792.86224 7141.388753 1.051307755 0.072185059 0.768031747 1 160.1248114 165.5235065 682 basigin (Ok blood group) "GO:0000139,GO:0001525,GO:0001618,GO:0001750,GO:0001917,GO:0002080,GO:0005515,GO:0005537,GO:0005739,GO:0005768,GO:0005789,GO:0005886,GO:0005887,GO:0005925,GO:0006090,GO:0007156,GO:0007166,GO:0007411,GO:0007566,GO:0016020,GO:0016323,GO:0022617,GO:0030198,GO:0030424,GO:0030593,GO:0042383,GO:0042470,GO:0042475,GO:0043231,GO:0043434,GO:0045121,GO:0045296,GO:0046689,GO:0046697,GO:0046718,GO:0050900,GO:0051591,GO:0070062,GO:0070593,GO:0072659,GO:0098632" Golgi membrane|angiogenesis|virus receptor activity|photoreceptor outer segment|photoreceptor inner segment|acrosomal membrane|protein binding|mannose binding|mitochondrion|endosome|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|focal adhesion|pyruvate metabolic process|homophilic cell adhesion via plasma membrane adhesion molecules|cell surface receptor signaling pathway|axon guidance|embryo implantation|membrane|basolateral plasma membrane|extracellular matrix disassembly|extracellular matrix organization|axon|neutrophil chemotaxis|sarcolemma|melanosome|odontogenesis of dentin-containing tooth|intracellular membrane-bounded organelle|response to peptide hormone|membrane raft|cadherin binding|response to mercury ion|decidualization|viral entry into host cell|leukocyte migration|response to cAMP|extracellular exosome|dendrite self-avoidance|protein localization to plasma membrane|cell-cell adhesion mediator activity BSN 6.123596406 9.363724944 2.883467868 0.307940257 -1.699277611 0.271781165 1 0.031289512 0.009474067 8927 bassoon presynaptic cytomatrix protein "GO:0005634,GO:0007268,GO:0008021,GO:0009986,GO:0014069,GO:0030424,GO:0030425,GO:0030672,GO:0035418,GO:0044306,GO:0046872,GO:0048786,GO:0048788,GO:0048790,GO:0060076,GO:0098685,GO:0098693,GO:0098882,GO:0098978,GO:0098982,GO:0099526,GO:1904071" nucleus|chemical synaptic transmission|synaptic vesicle|cell surface|postsynaptic density|axon|dendrite|synaptic vesicle membrane|protein localization to synapse|neuron projection terminus|metal ion binding|presynaptic active zone|cytoskeleton of presynaptic active zone|maintenance of presynaptic active zone structure|excitatory synapse|Schaffer collateral - CA1 synapse|regulation of synaptic vesicle cycle|structural constituent of presynaptic active zone|glutamatergic synapse|GABA-ergic synapse|presynapse to nucleus signaling pathway|presynaptic active zone assembly BSPRY 1.922311912 0 3.844623824 Inf Inf 0.288176591 1 0 0.086661121 54836 B-box and SPRY domain containing "GO:0005737,GO:0006816,GO:0008270,GO:0016020,GO:0016567,GO:0031252,GO:0048471,GO:0061630,GO:1990830" cytoplasm|calcium ion transport|zinc ion binding|membrane|protein ubiquitination|cell leading edge|perinuclear region of cytoplasm|ubiquitin protein ligase activity|cellular response to leukemia inhibitory factor BST1 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.010492248 0.028592275 683 bone marrow stromal cell antigen 1 "GO:0001931,GO:0001952,GO:0002691,GO:0003953,GO:0005576,GO:0005886,GO:0006959,GO:0007165,GO:0008284,GO:0016740,GO:0016849,GO:0019674,GO:0019898,GO:0030890,GO:0031225,GO:0032956,GO:0035579,GO:0043312,GO:0050135,GO:0050727,GO:0050730,GO:0050848,GO:0061809,GO:0061811,GO:0061812,GO:0070062,GO:0090022,GO:0090322,GO:2001044" "uropod|regulation of cell-matrix adhesion|regulation of cellular extravasation|NAD+ nucleosidase activity|extracellular region|plasma membrane|humoral immune response|signal transduction|positive regulation of cell population proliferation|transferase activity|phosphorus-oxygen lyase activity|NAD metabolic process|extrinsic component of membrane|positive regulation of B cell proliferation|anchored component of membrane|regulation of actin cytoskeleton organization|specific granule membrane|neutrophil degranulation|NAD(P)+ nucleosidase activity|regulation of inflammatory response|regulation of peptidyl-tyrosine phosphorylation|regulation of calcium-mediated signaling|NAD+ nucleotidase, cyclic ADP-ribose generating|ADP-ribosyl cyclase activity|cyclic ADP-ribose hydrolase|extracellular exosome|regulation of neutrophil chemotaxis|regulation of superoxide metabolic process|regulation of integrin-mediated signaling pathway" "hsa00760,hsa04970,hsa04972" Nicotinate and nicotinamide metabolism|Salivary secretion|Pancreatic secretion BST2 2134.601849 1901.876577 2367.32712 1.244732254 0.315835448 0.181724856 1 101.3982592 124.1016687 684 bone marrow stromal cell antigen 2 "GO:0002737,GO:0003723,GO:0005515,GO:0005737,GO:0005771,GO:0005794,GO:0005829,GO:0005886,GO:0008191,GO:0009615,GO:0009986,GO:0010951,GO:0016020,GO:0016021,GO:0016324,GO:0030308,GO:0030336,GO:0031225,GO:0032956,GO:0034341,GO:0035455,GO:0035456,GO:0035577,GO:0042113,GO:0042802,GO:0042803,GO:0043123,GO:0043312,GO:0045071,GO:0045087,GO:0045121,GO:0051607,GO:0060337,GO:0070062,GO:0070665,GO:1901253" negative regulation of plasmacytoid dendritic cell cytokine production|RNA binding|protein binding|cytoplasm|multivesicular body|Golgi apparatus|cytosol|plasma membrane|metalloendopeptidase inhibitor activity|response to virus|cell surface|negative regulation of endopeptidase activity|membrane|integral component of membrane|apical plasma membrane|negative regulation of cell growth|negative regulation of cell migration|anchored component of membrane|regulation of actin cytoskeleton organization|response to interferon-gamma|response to interferon-alpha|response to interferon-beta|azurophil granule membrane|B cell activation|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|neutrophil degranulation|negative regulation of viral genome replication|innate immune response|membrane raft|defense response to virus|type I interferon signaling pathway|extracellular exosome|positive regulation of leukocyte proliferation|negative regulation of intracellular transport of viral material "hsa05168,hsa05170" Herpes simplex virus 1 infection|Human immunodeficiency virus 1 infection BTAF1 5504.363559 5408.071362 5600.655756 1.03561055 0.050481567 0.834756553 1 34.87419393 35.5117294 9044 B-TFIID TATA-box binding protein associated factor 1 "GO:0003677,GO:0003712,GO:0004386,GO:0005524,GO:0005654,GO:0008094,GO:0035562,GO:0043231,GO:0045892" "DNA binding|transcription coregulator activity|helicase activity|ATP binding|nucleoplasm|DNA-dependent ATPase activity|negative regulation of chromatin binding|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated" other BTBD1 1639.12338 1510.680958 1767.565803 1.170045729 0.226564917 0.340975973 1 25.24178654 29.0398323 53339 BTB domain containing 1 "GO:0000932,GO:0005515,GO:0005654,GO:0005829,GO:0007517,GO:0016567,GO:0022008,GO:0032991,GO:0036464,GO:0042802,GO:0043393,GO:0043687,GO:0097602" P-body|protein binding|nucleoplasm|cytosol|muscle organ development|protein ubiquitination|neurogenesis|protein-containing complex|cytoplasmic ribonucleoprotein granule|identical protein binding|regulation of protein binding|post-translational protein modification|cullin family protein binding BTBD10 1328.844842 1275.54742 1382.142265 1.08356792 0.115789587 0.631660571 1 23.34486332 24.87245496 84280 BTB domain containing 10 "GO:0001650,GO:0005515,GO:0005654,GO:0005737,GO:0042327,GO:0044342,GO:1901215" fibrillar center|protein binding|nucleoplasm|cytoplasm|positive regulation of phosphorylation|type B pancreatic cell proliferation|negative regulation of neuron death BTBD11 821.57142 637.7737101 1005.36913 1.576372801 0.656608763 0.00897879 0.582287276 3.912277095 6.064007344 121551 BTB domain containing 11 "GO:0016021,GO:0046982,GO:0060395" integral component of membrane|protein heterodimerization activity|SMAD protein signal transduction BTBD19 112.8062627 122.7688382 102.8436873 0.837701886 -0.255491173 0.578905227 1 1.586812122 1.307031882 149478 BTB domain containing 19 BTBD2 1165.423792 1237.052106 1093.795478 0.884195154 -0.177563267 0.465375881 1 24.55157952 21.34512717 55643 BTB domain containing 2 "GO:0000932,GO:0005515,GO:0005829,GO:0022008" P-body|protein binding|cytosol|neurogenesis BTBD3 1104.980407 1164.223135 1045.73768 0.898227882 -0.15484659 0.526633334 1 12.08567379 10.67403391 22903 BTB domain containing 3 "GO:0005515,GO:0005634,GO:0005829,GO:0021987,GO:0022008,GO:0042802,GO:0048813" protein binding|nucleus|cytosol|cerebral cortex development|neurogenesis|identical protein binding|dendrite morphogenesis BTBD6 691.3247271 662.7436432 719.905811 1.086250798 0.119357236 0.645426421 1 17.72014538 18.9264241 90135 BTB domain containing 6 "GO:0005829,GO:0022008,GO:0043687" cytosol|neurogenesis|post-translational protein modification BTBD7 1015.440032 1046.656366 984.2236989 0.940350368 -0.0887297 0.720615729 1 5.841067299 5.400737729 55727 BTB domain containing 7 "GO:0005634,GO:0007275,GO:0060693,GO:0061138" nucleus|multicellular organism development|regulation of branching involved in salivary gland morphogenesis|morphogenesis of a branching epithelium BTBD8 267.1303155 275.7096789 258.5509522 0.937765236 -0.092701297 0.786832199 1 2.378616041 2.193257641 284697 BTB domain containing 8 "GO:0005654,GO:0008021,GO:0030122,GO:0030424,GO:0031175,GO:0036466,GO:0044297,GO:0044306,GO:0098793,GO:0150007" nucleoplasm|synaptic vesicle|AP-2 adaptor complex|axon|neuron projection development|synaptic vesicle recycling via endosome|cell body|neuron projection terminus|presynapse|clathrin-dependent synaptic vesicle endocytosis BTBD9 202.5548433 220.5677431 184.5419436 0.836667869 -0.257273064 0.481787594 1 0.949987496 0.78152371 114781 BTB domain containing 9 "GO:0007616,GO:0008344,GO:0042428,GO:0042748,GO:0048512,GO:0050804,GO:0050951,GO:0060586,GO:1900242" "long-term memory|adult locomotory behavior|serotonin metabolic process|circadian sleep/wake cycle, non-REM sleep|circadian behavior|modulation of chemical synaptic transmission|sensory perception of temperature stimulus|multicellular organismal iron ion homeostasis|regulation of synaptic vesicle endocytosis" BTC 23.37471381 33.29324424 13.45618338 0.404171588 -1.306960188 0.104535127 1 0.41504304 0.164941559 685 betacellulin "GO:0000165,GO:0005154,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0007165,GO:0007173,GO:0008083,GO:0008284,GO:0016021,GO:0030665,GO:0035810,GO:0038128,GO:0042059,GO:0043066,GO:0045597,GO:0045741,GO:0045840,GO:0048146,GO:0051781,GO:0051897,GO:0061024,GO:2000145" MAPK cascade|epidermal growth factor receptor binding|protein binding|extracellular region|extracellular space|plasma membrane|signal transduction|epidermal growth factor receptor signaling pathway|growth factor activity|positive regulation of cell population proliferation|integral component of membrane|clathrin-coated vesicle membrane|positive regulation of urine volume|ERBB2 signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of apoptotic process|positive regulation of cell differentiation|positive regulation of epidermal growth factor-activated receptor activity|positive regulation of mitotic nuclear division|positive regulation of fibroblast proliferation|positive regulation of cell division|positive regulation of protein kinase B signaling|membrane organization|regulation of cell motility hsa04012 ErbB signaling pathway BTD 493.3869652 512.9240441 473.8498863 0.923820772 -0.11431511 0.681652438 1 1.91626276 1.740660047 686 biotinidase "GO:0005576,GO:0005615,GO:0005759,GO:0006768,GO:0007417,GO:0047708,GO:0070062" extracellular region|extracellular space|mitochondrial matrix|biotin metabolic process|central nervous system development|biotinidase activity|extracellular exosome "hsa00780,hsa04977" Biotin metabolism|Vitamin digestion and absorption BTF3 12396.05329 11368.6025 13423.50408 1.180752347 0.239706403 0.350608312 1 586.2042711 680.5796742 689 basic transcription factor 3 "GO:0001701,GO:0003723,GO:0005515,GO:0005634,GO:0005829,GO:0005854,GO:0006366,GO:0015031,GO:0042788" in utero embryonic development|RNA binding|protein binding|nucleus|cytosol|nascent polypeptide-associated complex|transcription by RNA polymerase II|protein transport|polysomal ribosome BTF3L4 1117.229443 880.1901447 1354.268742 1.5386093 0.621626933 0.01082479 0.620526829 10.36270247 15.67734663 91408 basic transcription factor 3 like 4 GO:0005515 protein binding BTG1 1595.667573 1618.884001 1572.451144 0.971317984 -0.041984422 0.862423001 1 18.66426091 17.82556915 694 BTG anti-proliferation factor 1 "GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0008285,GO:0016477,GO:0019899,GO:0019900,GO:0030308,GO:0045603,GO:0045663,GO:0045766,GO:0045930,GO:2000271" "transcription coregulator activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|negative regulation of cell population proliferation|cell migration|enzyme binding|kinase binding|negative regulation of cell growth|positive regulation of endothelial cell differentiation|positive regulation of myoblast differentiation|positive regulation of angiogenesis|negative regulation of mitotic cell cycle|positive regulation of fibroblast apoptotic process" hsa03018 RNA degradation BTG2 23.37974423 20.80827765 25.95121081 1.247158042 0.318644297 0.730254613 1 0.406925443 0.499008008 7832 BTG anti-proliferation factor 2 "GO:0000122,GO:0003714,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006281,GO:0006479,GO:0006974,GO:0006977,GO:0008285,GO:0008306,GO:0009612,GO:0009952,GO:0014070,GO:0017148,GO:0021542,GO:0021954,GO:0031175,GO:0035914,GO:0043434,GO:0043524,GO:0045930,GO:0051602,GO:0060213,GO:0070062,GO:2000178" "negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleus|cytoplasm|cytosol|DNA repair|protein methylation|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell population proliferation|associative learning|response to mechanical stimulus|anterior/posterior pattern specification|response to organic cyclic compound|negative regulation of translation|dentate gyrus development|central nervous system neuron development|neuron projection development|skeletal muscle cell differentiation|response to peptide hormone|negative regulation of neuron apoptotic process|negative regulation of mitotic cell cycle|response to electrical stimulus|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|extracellular exosome|negative regulation of neural precursor cell proliferation" hsa03018 RNA degradation BTG3 1447.309829 1269.304937 1625.314722 1.280476168 0.356680402 0.135784527 1 29.74987773 37.45655778 10950 BTG anti-proliferation factor 3 "GO:0005515,GO:0005634,GO:0005737,GO:0008285,GO:0045930" protein binding|nucleus|cytoplasm|negative regulation of cell population proliferation|negative regulation of mitotic cell cycle hsa03018 RNA degradation BTG4 2.561405743 4.161655531 0.961155956 0.230955193 -2.11431511 0.482263142 1 0.042507159 0.009652971 54766 BTG anti-proliferation factor 4 "GO:0005575,GO:0005634,GO:0005737,GO:0007050,GO:0008285,GO:0030182,GO:0045930" cellular_component|nucleus|cytoplasm|cell cycle arrest|negative regulation of cell population proliferation|neuron differentiation|negative regulation of mitotic cell cycle hsa03018 RNA degradation BTN2A1 656.2425347 662.7436432 649.7414263 0.980381227 -0.028585236 0.91816107 1 9.770555295 9.41857959 11120 butyrophilin subfamily 2 member A1 "GO:0001817,GO:0003674,GO:0005102,GO:0005886,GO:0005887,GO:0006629,GO:0009897,GO:0050852" regulation of cytokine production|molecular_function|signaling receptor binding|plasma membrane|integral component of plasma membrane|lipid metabolic process|external side of plasma membrane|T cell receptor signaling pathway BTN2A2 484.5981674 458.8225222 510.3738126 1.112355623 0.153618095 0.580817279 1 5.904633405 6.458144713 10385 butyrophilin subfamily 2 member A2 "GO:0001817,GO:0001818,GO:0005102,GO:0005515,GO:0005886,GO:0009897,GO:0016021,GO:0031324,GO:0046007,GO:0050852" regulation of cytokine production|negative regulation of cytokine production|signaling receptor binding|protein binding|plasma membrane|external side of plasma membrane|integral component of membrane|negative regulation of cellular metabolic process|negative regulation of activated T cell proliferation|T cell receptor signaling pathway BTN3A1 356.1901125 393.2764476 319.1037774 0.811398138 -0.301518103 0.314117103 1 5.05623734 4.033969748 11119 butyrophilin subfamily 3 member A1 "GO:0001816,GO:0001817,GO:0002250,GO:0005102,GO:0005515,GO:0005886,GO:0009897,GO:0016021,GO:0032609,GO:0050798,GO:0050852" cytokine production|regulation of cytokine production|adaptive immune response|signaling receptor binding|protein binding|plasma membrane|external side of plasma membrane|integral component of membrane|interferon-gamma production|activated T cell proliferation|T cell receptor signaling pathway BTN3A2 562.8971649 546.2172884 579.5770415 1.061074144 0.085525469 0.753392342 1 7.995231151 8.341572609 11118 butyrophilin subfamily 3 member A2 "GO:0001817,GO:0002456,GO:0005102,GO:0005515,GO:0005886,GO:0009897,GO:0016020,GO:0016021,GO:0032609,GO:0050852" regulation of cytokine production|T cell mediated immunity|signaling receptor binding|protein binding|plasma membrane|external side of plasma membrane|membrane|integral component of membrane|interferon-gamma production|T cell receptor signaling pathway BTN3A3 217.7351938 215.3656737 220.1047139 1.022004622 0.031401721 0.943011036 1 3.86992262 3.888895916 10384 butyrophilin subfamily 3 member A3 "GO:0001817,GO:0002456,GO:0005102,GO:0005886,GO:0009897,GO:0016020,GO:0016021,GO:0050852" regulation of cytokine production|T cell mediated immunity|signaling receptor binding|plasma membrane|external side of plasma membrane|membrane|integral component of membrane|T cell receptor signaling pathway BTNL9 12.41073908 10.40413883 14.41733934 1.385731158 0.470647391 0.70561241 1 0.108025247 0.147189024 153579 butyrophilin like 9 "GO:0001817,GO:0005102,GO:0005886,GO:0009897,GO:0016021,GO:0050852" regulation of cytokine production|signaling receptor binding|plasma membrane|external side of plasma membrane|integral component of membrane|T cell receptor signaling pathway BTRC 1561.863568 1627.207312 1496.519823 0.919686024 -0.120786678 0.613453497 1 12.81597751 11.58944135 8945 beta-transducin repeat containing E3 ubiquitin protein ligase "GO:0000086,GO:0000209,GO:0002223,GO:0004842,GO:0005515,GO:0005654,GO:0005829,GO:0006470,GO:0006511,GO:0007165,GO:0008013,GO:0016032,GO:0016055,GO:0016567,GO:0016874,GO:0019005,GO:0031146,GO:0031648,GO:0033598,GO:0038061,GO:0038095,GO:0042752,GO:0042753,GO:0043122,GO:0043161,GO:0043433,GO:0043687,GO:0045309,GO:0045862,GO:0045879,GO:0045892,GO:0045893,GO:0046983,GO:0048511,GO:0050852,GO:0051403,GO:0060444,GO:0060828,GO:0061136,GO:0061630,GO:0070498,GO:0070936,GO:0071407,GO:1901990,GO:1904668,GO:1990756,GO:1990757" "G2/M transition of mitotic cell cycle|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytosol|protein dephosphorylation|ubiquitin-dependent protein catabolic process|signal transduction|beta-catenin binding|viral process|Wnt signaling pathway|protein ubiquitination|ligase activity|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein destabilization|mammary gland epithelial cell proliferation|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|regulation of circadian rhythm|positive regulation of circadian rhythm|regulation of I-kappaB kinase/NF-kappaB signaling|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of DNA-binding transcription factor activity|post-translational protein modification|protein phosphorylated amino acid binding|positive regulation of proteolysis|negative regulation of smoothened signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein dimerization activity|rhythmic process|T cell receptor signaling pathway|stress-activated MAPK cascade|branching involved in mammary gland duct morphogenesis|regulation of canonical Wnt signaling pathway|regulation of proteasomal protein catabolic process|ubiquitin protein ligase activity|interleukin-1-mediated signaling pathway|protein K48-linked ubiquitination|cellular response to organic cyclic compound|regulation of mitotic cell cycle phase transition|positive regulation of ubiquitin protein ligase activity|ubiquitin ligase-substrate adaptor activity|ubiquitin ligase activator activity" "hsa04114,hsa04120,hsa04218,hsa04310,hsa04340,hsa04390,hsa04710,hsa05131,hsa05170" Oocyte meiosis|Ubiquitin mediated proteolysis|Cellular senescence|Wnt signaling pathway|Hedgehog signaling pathway|Hippo signaling pathway|Circadian rhythm|Shigellosis|Human immunodeficiency virus 1 infection BUB1 3203.65718 3170.1411 3237.17326 1.02114485 0.030187528 0.899910116 1 44.97198407 45.15445224 699 BUB1 mitotic checkpoint serine/threonine kinase "GO:0000776,GO:0000777,GO:0000778,GO:0000942,GO:0004672,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006468,GO:0006915,GO:0007063,GO:0007093,GO:0007094,GO:0008283,GO:0016020,GO:0016032,GO:0043231,GO:0051301,GO:0051754,GO:0051983,GO:0106310,GO:0106311" "kinetochore|condensed chromosome kinetochore|condensed nuclear chromosome kinetochore|condensed nuclear chromosome outer kinetochore|protein kinase activity|protein binding|ATP binding|nucleoplasm|cytosol|protein phosphorylation|apoptotic process|regulation of sister chromatid cohesion|mitotic cell cycle checkpoint|mitotic spindle assembly checkpoint|cell population proliferation|membrane|viral process|intracellular membrane-bounded organelle|cell division|meiotic sister chromatid cohesion, centromeric|regulation of chromosome segregation|protein serine kinase activity|protein threonine kinase activity" "hsa04110,hsa04114,hsa04914" Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation BUB1B 1625.13067 1748.935737 1501.325603 0.858422395 -0.220240381 0.35473378 1 25.4394892 21.47240077 701 BUB1 mitotic checkpoint serine/threonine kinase B "GO:0000278,GO:0000776,GO:0000777,GO:0000778,GO:0000940,GO:0004672,GO:0005515,GO:0005524,GO:0005680,GO:0005737,GO:0005815,GO:0005819,GO:0005829,GO:0006468,GO:0006511,GO:0006915,GO:0007091,GO:0007093,GO:0007094,GO:0031145,GO:0048471,GO:0051301,GO:0051754,GO:0071459,GO:0106310,GO:0106311,GO:1901990" "mitotic cell cycle|kinetochore|condensed chromosome kinetochore|condensed nuclear chromosome kinetochore|condensed chromosome outer kinetochore|protein kinase activity|protein binding|ATP binding|anaphase-promoting complex|cytoplasm|microtubule organizing center|spindle|cytosol|protein phosphorylation|ubiquitin-dependent protein catabolic process|apoptotic process|metaphase/anaphase transition of mitotic cell cycle|mitotic cell cycle checkpoint|mitotic spindle assembly checkpoint|anaphase-promoting complex-dependent catabolic process|perinuclear region of cytoplasm|cell division|meiotic sister chromatid cohesion, centromeric|protein localization to chromosome, centromeric region|protein serine kinase activity|protein threonine kinase activity|regulation of mitotic cell cycle phase transition" "hsa04110,hsa05166" Cell cycle|Human T-cell leukemia virus 1 infection BUB1B-PAK6 2.601034707 5.202069413 0 0 #NAME? 0.147074026 1 0.071571251 0 106821730 BUB1B-PAK6 readthrough "hsa04012,hsa04014,hsa04360,hsa04510,hsa04660,hsa04810,hsa05170,hsa05211" ErbB signaling pathway|Ras signaling pathway|Axon guidance|Focal adhesion|T cell receptor signaling pathway|Regulation of actin cytoskeleton|Human immunodeficiency virus 1 infection|Renal cell carcinoma BUB3 3993.243726 3674.741833 4311.745619 1.173346541 0.230629168 0.332893704 1 25.45945966 29.37288859 9184 BUB3 mitotic checkpoint protein "GO:0000070,GO:0000776,GO:0000777,GO:0005515,GO:0005654,GO:0005829,GO:0006511,GO:0007094,GO:0008608,GO:0031145,GO:0033597,GO:0034501,GO:0043130,GO:0051301,GO:0051321,GO:1901990,GO:1990298" mitotic sister chromatid segregation|kinetochore|condensed chromosome kinetochore|protein binding|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|mitotic spindle assembly checkpoint|attachment of spindle microtubules to kinetochore|anaphase-promoting complex-dependent catabolic process|mitotic checkpoint complex|protein localization to kinetochore|ubiquitin binding|cell division|meiotic cell cycle|regulation of mitotic cell cycle phase transition|bub1-bub3 complex "hsa04110,hsa05166" Cell cycle|Human T-cell leukemia virus 1 infection BUD13 616.4344349 563.9043244 668.9645454 1.186308592 0.246479345 0.347338321 1 10.21538947 11.91581587 84811 BUD13 homolog "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005684,GO:0070274,GO:0071005" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U2-type spliceosomal complex|RES complex|U2-type precatalytic spliceosome" BUD23 1010.139198 983.1911191 1037.087277 1.05481758 0.07699352 0.757059319 1 41.05720109 42.58315914 114049 BUD23 rRNA methyltransferase and ribosome maturation factor "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006325,GO:0008168,GO:0016435,GO:0031167,GO:0046982,GO:0048471,GO:0070476,GO:2000234" RNA binding|protein binding|nucleoplasm|nucleolus|chromatin organization|methyltransferase activity|rRNA (guanine) methyltransferase activity|rRNA methylation|protein heterodimerization activity|perinuclear region of cytoplasm|rRNA (guanine-N7)-methylation|positive regulation of rRNA processing BUD31 1220.591494 1183.990998 1257.19199 1.061825632 0.086546873 0.722825387 1 20.110574 20.99659397 8896 BUD31 homolog "GO:0000398,GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0030374,GO:0035257,GO:0045893,GO:0071007,GO:2000825" "mRNA splicing, via spliceosome|chromatin|protein binding|nucleus|nucleoplasm|spliceosomal complex|nuclear receptor coactivator activity|nuclear hormone receptor binding|positive regulation of transcription, DNA-templated|U2-type catalytic step 2 spliceosome|positive regulation of androgen receptor activity" hsa03040 Spliceosome BYSL 466.0537711 464.0245917 468.0829506 1.008746 0.012562952 0.972592269 1 14.41451666 14.297269 705 bystin like "GO:0000462,GO:0001829,GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0008283,GO:0016020,GO:0030515,GO:0030688,GO:0042254,GO:0043231,GO:0045177,GO:1904749" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|trophectodermal cell differentiation|RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|cytoplasm|cytosol|rRNA processing|cell population proliferation|membrane|snoRNA binding|preribosome, small subunit precursor|ribosome biogenesis|intracellular membrane-bounded organelle|apical part of cell|regulation of protein localization to nucleolus" BZW1 5125.297474 4439.446037 5811.14891 1.308980639 0.388443759 0.106229964 1 70.70279787 90.99991814 9689 basic leucine zipper and W2 domains 1 "GO:0003723,GO:0005737,GO:0016020,GO:0045296" RNA binding|cytoplasm|membrane|cadherin binding BZW2 1292.622857 1321.325631 1263.920082 0.956554579 -0.064080807 0.792749603 1 35.06549997 32.98078352 28969 basic leucine zipper and W2 domains 2 "GO:0005515,GO:0005737,GO:0007399,GO:0016020,GO:0030154,GO:0045296" protein binding|cytoplasm|nervous system development|membrane|cell differentiation|cadherin binding C10orf88 321.8268863 298.5987843 345.0549882 1.155580687 0.208617997 0.502259572 1 5.470534953 6.215860377 80007 chromosome 10 open reading frame 88 "GO:0005515,GO:0005737,GO:0005739,GO:0016887,GO:0042802" protein binding|cytoplasm|mitochondrion|ATPase activity|identical protein binding C10orf90 39.19415812 32.25283036 46.13548589 1.430432163 0.51645108 0.443713718 1 0.343156754 0.482648539 118611 chromosome 10 open reading frame 90 "GO:0000209,GO:0005654,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0008017,GO:0015629,GO:0016567,GO:0046599,GO:0050821,GO:0061630" protein polyubiquitination|nucleoplasm|cytoplasm|centrosome|centriole|cytosol|plasma membrane|microtubule binding|actin cytoskeleton|protein ubiquitination|regulation of centriole replication|protein stabilization|ubiquitin protein ligase activity C10orf95 4.003139677 4.161655531 3.844623824 0.923820772 -0.11431511 1 1 0.151191223 0.137336344 79946 chromosome 10 open reading frame 95 C11orf1 304.0058721 297.5583704 310.4533738 1.043336046 0.061203908 0.855158723 1 5.749508813 5.898290178 64776 chromosome 11 open reading frame 1 "GO:0003674,GO:0005515,GO:0005654,GO:0008150" molecular_function|protein binding|nucleoplasm|biological_process C11orf24 698.3547593 708.5218541 688.1876645 0.971300547 -0.042010321 0.875230531 1 15.74865021 15.04070346 53838 chromosome 11 open reading frame 24 "GO:0005515,GO:0005654,GO:0005794,GO:0005886,GO:0016021,GO:0043231" protein binding|nucleoplasm|Golgi apparatus|plasma membrane|integral component of membrane|intracellular membrane-bounded organelle C11orf49 675.5354653 588.8742576 762.1966731 1.294328396 0.372203703 0.148598679 1 6.387629435 8.129341561 79096 chromosome 11 open reading frame 49 GO:0005515 protein binding C11orf52 4.483717655 4.161655531 4.80577978 1.154775965 0.207612985 1 1 0.201177452 0.228427411 91894 chromosome 11 open reading frame 52 "GO:0005515,GO:0070062" protein binding|extracellular exosome C11orf54 363.5176691 396.3976893 330.6376489 0.834105894 -0.261697543 0.380273308 1 3.804859016 3.120548506 28970 chromosome 11 open reading frame 54 "GO:0005515,GO:0005634,GO:0005654,GO:0008270,GO:0016604,GO:0016788,GO:0070062" "protein binding|nucleus|nucleoplasm|zinc ion binding|nuclear body|hydrolase activity, acting on ester bonds|extracellular exosome" C11orf58 2884.903689 2598.953879 3170.853499 1.22004993 0.286940191 0.225349616 1 22.42182215 26.89798125 10944 chromosome 11 open reading frame 58 "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process C11orf65 8.447228369 7.282897178 9.61155956 1.31974396 0.400258063 0.833324456 1 0.091452903 0.118674758 160140 chromosome 11 open reading frame 65 "GO:0005515,GO:0005741,GO:0005829,GO:0090258,GO:1903215" protein binding|mitochondrial outer membrane|cytosol|negative regulation of mitochondrial fission|negative regulation of protein targeting to mitochondrion C11orf68 1062.74488 1026.888502 1098.601258 1.069834997 0.097388304 0.693013354 1 35.08524457 36.90731806 83638 chromosome 11 open reading frame 68 "GO:0003723,GO:0005515" RNA binding|protein binding C11orf71 82.10399235 86.35435226 77.85363244 0.90156003 -0.149504538 0.785767085 1 2.091953276 1.854461444 54494 chromosome 11 open reading frame 71 "GO:0005654,GO:0016604" nucleoplasm|nuclear body C11orf80 433.7216828 397.4381032 470.0052625 1.182587323 0.241946717 0.394730532 1 9.118891275 10.60343151 79703 chromosome 11 open reading frame 80 "GO:0005694,GO:0007131,GO:0042138" chromosome|reciprocal meiotic recombination|meiotic DNA double-strand break formation C11orf86 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.129546504 254439 chromosome 11 open reading frame 86 C11orf91 17.41466368 15.60620824 19.22311912 1.231761029 0.300722389 0.792076496 1 0.696966235 0.844130081 100131378 chromosome 11 open reading frame 91 C11orf94 4.562975582 6.242483296 2.883467868 0.461910386 -1.11431511 0.584550016 1 0.930586202 0.422654517 143678 chromosome 11 open reading frame 94 GO:0005576 extracellular region C11orf96 41.19572796 34.33365813 48.0577978 1.399728442 0.485146961 0.464436721 1 1.475301314 2.030465876 387763 chromosome 11 open reading frame 96 C12orf29 827.3918472 803.1995174 851.584177 1.060239901 0.084390741 0.740002314 1 15.15209686 15.79603404 91298 chromosome 12 open reading frame 29 GO:0002244 hematopoietic progenitor cell differentiation C12orf4 345.7413143 383.9127227 307.5699059 0.801145385 -0.319864021 0.289531696 1 4.505985575 3.54954193 57102 chromosome 12 open reading frame 4 "GO:0005515,GO:0005737,GO:0043304" protein binding|cytoplasm|regulation of mast cell degranulation C12orf43 381.8192612 397.4381032 366.2004192 0.921402393 -0.11809675 0.693028268 1 4.398702013 3.985153519 64897 chromosome 12 open reading frame 43 "GO:0005515,GO:0005635,GO:0007275,GO:0016055,GO:0030178,GO:0060061" protein binding|nuclear envelope|multicellular organism development|Wnt signaling pathway|negative regulation of Wnt signaling pathway|Spemann organizer formation C12orf57 764.9418622 740.7746844 789.1090399 1.06524839 0.091189871 0.722388183 1 44.57021806 46.68386709 113246 chromosome 12 open reading frame 57 "GO:0003674,GO:0005515,GO:0005737,GO:0009791,GO:0014819,GO:0016607,GO:0021540,GO:0021678,GO:0036343,GO:0048593,GO:0050890" molecular_function|protein binding|cytoplasm|post-embryonic development|regulation of skeletal muscle contraction|nuclear speck|corpus callosum morphogenesis|third ventricle development|psychomotor behavior|camera-type eye morphogenesis|cognition C12orf60 51.75838264 59.30359131 44.21317398 0.74553957 -0.423643168 0.485647153 1 0.815491799 0.59780766 144608 chromosome 12 open reading frame 60 GO:0005515 protein binding C12orf73 203.4468022 193.5169822 213.3766222 1.102624792 0.140941945 0.706192833 1 2.875980415 3.118062786 728568 chromosome 12 open reading frame 73 "GO:0005515,GO:0005739,GO:0005743,GO:0016021,GO:0034551" protein binding|mitochondrion|mitochondrial inner membrane|integral component of membrane|mitochondrial respiratory chain complex III assembly C12orf75 3555.917036 2980.785774 4131.048299 1.385892383 0.470815234 0.047624066 1 121.3417683 165.3525916 387882 chromosome 12 open reading frame 75 C12orf76 194.8165203 143.5771158 246.0559247 1.713754475 0.777160433 0.03455063 0.946853433 4.316871429 7.274261253 400073 chromosome 12 open reading frame 76 C13orf46 19.69363626 24.96993318 14.41733934 0.577387982 -0.792387015 0.366853864 1 0.236864458 0.134474153 100507747 chromosome 13 open reading frame 46 C14orf119 1644.22104 1581.429102 1707.012978 1.079411639 0.110245148 0.644281061 1 61.20229486 64.95700342 55017 chromosome 14 open reading frame 119 "GO:0005515,GO:0005739,GO:0005829" protein binding|mitochondrion|cytosol C14orf132 16.01255871 16.64662212 15.3784953 0.923820772 -0.11431511 0.976849093 1 0.095980945 0.087185432 56967 chromosome 14 open reading frame 132 GO:0016021 integral component of membrane C14orf28 144.360863 131.0921492 157.6295768 1.202433385 0.265956971 0.52547098 1 2.296077147 2.714680232 122525 chromosome 14 open reading frame 28 C14orf93 694.6485296 762.623376 626.6736833 0.821734165 -0.283256344 0.269826592 1 6.22797367 5.032100318 60686 chromosome 14 open reading frame 93 "GO:0003723,GO:0005515,GO:0005576,GO:0010628,GO:0030154,GO:0048856" RNA binding|protein binding|extracellular region|positive regulation of gene expression|cell differentiation|anatomical structure development C15orf39 132.0539196 161.2641518 102.8436873 0.637734339 -0.648972529 0.126333882 1 1.944942687 1.219601049 56905 chromosome 15 open reading frame 39 GO:0005829 cytosol C15orf40 351.9988889 358.9427895 345.0549882 0.961309151 -0.056927628 0.858430628 1 1.454416291 1.374747648 123207 chromosome 15 open reading frame 40 GO:0005737 cytoplasm C15orf48 8.085537281 10.40413883 5.766935736 0.554292463 -0.851280704 0.546153423 1 0.855546637 0.466287572 84419 chromosome 15 open reading frame 48 "GO:0004129,GO:0005515,GO:0005634,GO:0005751,GO:0022900,GO:1902600" cytochrome-c oxidase activity|protein binding|nucleus|mitochondrial respiratory chain complex IV|electron transport chain|proton transmembrane transport C15orf61 94.11341138 98.83931885 89.38750391 0.904371913 -0.145011907 0.779843296 1 1.25801879 1.11867871 145853 chromosome 15 open reading frame 61 GO:0005576 extracellular region C15orf62 11.81127422 7.282897178 16.33965125 2.243564731 1.165792809 0.289034745 1 0.157358234 0.34713568 643338 chromosome 15 open reading frame 62 "GO:0005737,GO:0005739,GO:0005856,GO:0005886,GO:0007266,GO:0008360,GO:0030838,GO:0031274" cytoplasm|mitochondrion|cytoskeleton|plasma membrane|Rho protein signal transduction|regulation of cell shape|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly C15orf65 41.51275967 42.65696919 40.36855015 0.946352986 -0.079549692 0.941300631 1 2.622723555 2.440488985 145788 chromosome 15 open reading frame 65 GO:0005515 protein binding C16orf46 49.03343063 63.46524684 34.60161442 0.545205701 -0.875127446 0.147640475 1 1.190517954 0.638215749 123775 chromosome 16 open reading frame 46 "GO:0005654,GO:0005829" nucleoplasm|cytosol C16orf72 1405.846145 1303.638595 1508.053695 1.156803504 0.210143828 0.380731135 1 6.307597083 7.174550846 29035 chromosome 16 open reading frame 72 GO:0005515 protein binding C16orf74 367.2635277 343.3365813 391.1904741 1.139378952 0.18824766 0.52920171 1 20.11332856 22.53322322 404550 chromosome 16 open reading frame 74 GO:0005515 protein binding C16orf86 6.083967443 8.323311061 3.844623824 0.461910386 -1.11431511 0.492415049 1 0.145115914 0.065908883 388284 chromosome 16 open reading frame 86 C16orf87 347.9215217 340.2153396 355.6277037 1.045301791 0.063919525 0.8406636 1 2.447979963 2.516058484 388272 chromosome 16 open reading frame 87 GO:0005515 protein binding C16orf91 135.8243159 146.6983575 124.9502743 0.851749648 -0.231498649 0.591145664 1 8.537646365 7.150251262 283951 chromosome 16 open reading frame 91 GO:0016021 integral component of membrane C16orf95 47.32435479 31.21241648 63.4362931 2.032405698 1.023188414 0.096004504 1 1.491270637 2.980149486 100506581 chromosome 16 open reading frame 95 C17orf100 25.22279822 18.72744989 31.71814655 1.693671415 0.760154008 0.338030256 1 0.582769435 0.970503492 388327 chromosome 17 open reading frame 100 C17orf107 8.085537281 10.40413883 5.766935736 0.554292463 -0.851280704 0.546153423 1 0.173461346 0.094539405 100130311 chromosome 17 open reading frame 107 C17orf113 20.05532735 21.84869154 18.26196316 0.835837841 -0.258705019 0.811013347 1 0.312355883 0.256710066 110806298 chromosome 17 open reading frame 113 GO:0016021 integral component of membrane C17orf49 542.2272815 558.702255 525.7523079 0.941024138 -0.087696365 0.749214449 1 34.91441744 32.30552047 124944 chromosome 17 open reading frame 49 "GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0006325,GO:0016589,GO:0042802,GO:0071339" DNA binding|protein binding|nucleoplasm|cytosol|chromatin organization|NURF complex|identical protein binding|MLL1 complex other C17orf58 210.4176981 187.2744989 233.5608973 1.247158042 0.318644297 0.374632628 1 5.344650165 6.554083253 284018 chromosome 17 open reading frame 58 GO:0062023 collagen-containing extracellular matrix C17orf67 115.6054422 133.172977 98.03790751 0.736169677 -0.441889768 0.323189252 1 3.489051065 2.525552666 339210 chromosome 17 open reading frame 67 "GO:0005515,GO:0005576" protein binding|extracellular region C17orf75 426.234996 491.0753526 361.3946395 0.735925022 -0.442369308 0.119501875 1 5.526737455 3.999204219 64149 chromosome 17 open reading frame 75 "GO:0003674,GO:0005515,GO:0005802,GO:0006886,GO:0031410,GO:0099041" molecular_function|protein binding|trans-Golgi network|intracellular protein transport|cytoplasmic vesicle|vesicle tethering to Golgi C17orf80 847.8283729 872.9072475 822.7494983 0.942539429 -0.085375124 0.736164195 1 11.59419001 10.74511626 55028 chromosome 17 open reading frame 80 "GO:0003674,GO:0005515,GO:0008150,GO:0016021,GO:0070062" molecular_function|protein binding|biological_process|integral component of membrane|extracellular exosome C17orf97 16.89445674 14.56579436 19.22311912 1.31974396 0.400258063 0.706666422 1 0.422243169 0.547928 400566 chromosome 17 open reading frame 97 GO:0016598 protein arginylation C18orf21 320.6625551 305.8816815 335.4434286 1.096644386 0.133095771 0.672745957 1 9.048970707 9.757446538 83608 chromosome 18 open reading frame 21 C18orf25 830.3243905 880.1901447 780.4586363 0.886693223 -0.173493046 0.490262601 1 8.364339441 7.292496289 147339 chromosome 18 open reading frame 25 "GO:0005515,GO:0006511,GO:0016567,GO:0061630" protein binding|ubiquitin-dependent protein catabolic process|protein ubiquitination|ubiquitin protein ligase activity C18orf32 16.97371467 16.64662212 17.30080721 1.039298368 0.055609892 1 1 0.160129709 0.16363769 497661 chromosome 18 open reading frame 32 "GO:0005515,GO:0005783,GO:0005811,GO:0043123" protein binding|endoplasmic reticulum|lipid droplet|positive regulation of I-kappaB kinase/NF-kappaB signaling C18orf54 1548.8741 1462.821919 1634.926281 1.117652299 0.160471437 0.501608243 1 12.06057736 13.25397031 162681 chromosome 18 open reading frame 54 "GO:0005515,GO:0005576,GO:0008285" protein binding|extracellular region|negative regulation of cell population proliferation C19orf12 348.8034197 338.1345119 359.4723275 1.063104519 0.088283442 0.776997806 1 2.597986961 2.715714492 83636 chromosome 19 open reading frame 12 "GO:0005739,GO:0005783,GO:0005829,GO:0006914,GO:0006915,GO:0006979,GO:0016021,GO:0031966,GO:0051560" mitochondrion|endoplasmic reticulum|cytosol|autophagy|apoptotic process|response to oxidative stress|integral component of membrane|mitochondrial membrane|mitochondrial calcium ion homeostasis C19orf25 317.6602003 302.7604398 332.5599608 1.098426072 0.135437775 0.668111917 1 7.049637096 7.613928114 148223 chromosome 19 open reading frame 25 GO:0005515 protein binding C19orf33 1265.950107 1024.807674 1507.092539 1.470610122 0.55641482 0.02117717 0.821508434 126.3097045 182.6440163 64073 chromosome 19 open reading frame 33 "GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0008150" nucleus|nucleoplasm|cytosol|plasma membrane|biological_process C19orf44 323.4762115 379.7510672 267.2013558 0.703622396 -0.507126691 0.098766271 1 5.097237551 3.526514768 84167 chromosome 19 open reading frame 44 GO:0005515 protein binding C19orf47 222.4566852 225.7698125 219.143558 0.970650396 -0.042976328 0.915375231 1 1.013110229 0.966920382 126526 chromosome 19 open reading frame 47 "GO:0005515,GO:0005634,GO:0005654" protein binding|nucleus|nucleoplasm C19orf53 847.2691514 769.9062732 924.6320297 1.200967003 0.264196513 0.291042001 1 45.80655827 54.09161094 28974 chromosome 19 open reading frame 53 C19orf54 377.0235423 372.46817 381.5789145 1.024460465 0.03486431 0.914989465 1 4.73735502 4.772020645 284325 chromosome 19 open reading frame 54 C19orf73 5.003924597 5.202069413 4.80577978 0.923820772 -0.11431511 1 1 0.374157525 0.339870434 55150 chromosome 19 open reading frame 73 GO:0005515 protein binding C1D 208.4953862 187.2744989 229.7162735 1.226628691 0.294698602 0.41397435 1 4.28764299 5.171337878 10438 C1D nuclear receptor corepressor "GO:0000176,GO:0000178,GO:0000460,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0006915,GO:0010468" nuclear exosome (RNase complex)|exosome (RNase complex)|maturation of 5.8S rRNA|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|rRNA processing|apoptotic process|regulation of gene expression hsa03018 RNA degradation C1GALT1 853.7739462 827.1290367 880.4188557 1.064427455 0.090077628 0.721759229 1 5.465192087 5.71995586 56913 "core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1" "GO:0000139,GO:0001525,GO:0001822,GO:0005515,GO:0016021,GO:0016263,GO:0016266,GO:0016267,GO:0018215,GO:0030154,GO:0046872" "Golgi membrane|angiogenesis|kidney development|protein binding|integral component of membrane|glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|O-glycan processing|O-glycan processing, core 1|protein phosphopantetheinylation|cell differentiation|metal ion binding" "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis C1GALT1C1 967.382849 945.7362193 989.0294787 1.045777309 0.064575673 0.79696199 1 27.91604194 28.70544179 29071 C1GALT1 specific chaperone 1 "GO:0000139,GO:0005515,GO:0006493,GO:0016021,GO:0016263,GO:0016266,GO:0016267,GO:0018215,GO:0030168,GO:0036344,GO:0070062" "Golgi membrane|protein binding|protein O-linked glycosylation|integral component of membrane|glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|O-glycan processing|O-glycan processing, core 1|protein phosphopantetheinylation|platelet activation|platelet morphogenesis|extracellular exosome" "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis C1GALT1C1L 72.06154461 62.42483296 81.69825626 1.308746093 0.388185231 0.469428999 1 2.604768259 3.351935614 728819 C1GALT1 specific chaperone 1 like "GO:0016021,GO:0016263,GO:0016267,GO:0018215" "integral component of membrane|glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|O-glycan processing, core 1|protein phosphopantetheinylation" "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis C1QBP 1952.111165 1880.027886 2024.194443 1.076683202 0.10659382 0.653697999 1 85.8285996 90.86385166 708 complement C1q binding protein "GO:0000122,GO:0001849,GO:0003714,GO:0003729,GO:0005080,GO:0005515,GO:0005540,GO:0005615,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0006397,GO:0006915,GO:0006955,GO:0006958,GO:0007597,GO:0008134,GO:0008380,GO:0008494,GO:0009986,GO:0014065,GO:0016020,GO:0016032,GO:0030449,GO:0030984,GO:0031690,GO:0032689,GO:0032695,GO:0039534,GO:0039536,GO:0042256,GO:0043065,GO:0045087,GO:0045785,GO:0048025,GO:0048786,GO:0050687,GO:0051897,GO:0070131,GO:0090023,GO:0097177,GO:0098978,GO:0098982,GO:1900026,GO:1901165,GO:2000510" "negative regulation of transcription by RNA polymerase II|complement component C1q complex binding|transcription corepressor activity|mRNA binding|protein kinase C binding|protein binding|hyaluronic acid binding|extracellular space|nucleus|nucleolus|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|plasma membrane|mRNA processing|apoptotic process|immune response|complement activation, classical pathway|blood coagulation, intrinsic pathway|transcription factor binding|RNA splicing|translation activator activity|cell surface|phosphatidylinositol 3-kinase signaling|membrane|viral process|regulation of complement activation|kininogen binding|adrenergic receptor binding|negative regulation of interferon-gamma production|negative regulation of interleukin-12 production|negative regulation of MDA-5 signaling pathway|negative regulation of RIG-I signaling pathway|mature ribosome assembly|positive regulation of apoptotic process|innate immune response|positive regulation of cell adhesion|negative regulation of mRNA splicing, via spliceosome|presynaptic active zone|negative regulation of defense response to virus|positive regulation of protein kinase B signaling|positive regulation of mitochondrial translation|positive regulation of neutrophil chemotaxis|mitochondrial ribosome binding|glutamatergic synapse|GABA-ergic synapse|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of trophoblast cell migration|positive regulation of dendritic cell chemotaxis" C1QL1 50.64374125 42.65696919 58.63051332 1.374465051 0.458870223 0.452978266 1 1.490847443 2.014828496 10882 complement C1q like 1 "GO:0003674,GO:0005102,GO:0005515,GO:0005575,GO:0005581,GO:0005737,GO:0007626,GO:0016322,GO:0043083,GO:0044301,GO:0061743,GO:0098793,GO:0099558" molecular_function|signaling receptor binding|protein binding|cellular_component|collagen trimer|cytoplasm|locomotory behavior|neuron remodeling|synaptic cleft|climbing fiber|motor learning|presynapse|maintenance of synapse structure C1QL4 94.4851633 70.74814402 118.2221826 1.671028749 0.740736554 0.121371948 1 1.821369231 2.992630487 338761 complement C1q like 4 "GO:0005515,GO:0005581,GO:0005615,GO:0042802,GO:0045599,GO:0048147,GO:0070373" protein binding|collagen trimer|extracellular space|identical protein binding|negative regulation of fat cell differentiation|negative regulation of fibroblast proliferation|negative regulation of ERK1 and ERK2 cascade C1QTNF1 1214.054674 1504.438474 923.6708737 0.613963874 -0.703774326 0.003701923 0.381043789 16.76181969 10.11894326 114897 C1q and TNF related 1 "GO:0005515,GO:0005518,GO:0005581,GO:0005615,GO:0005887,GO:0007204,GO:0010544,GO:0010628,GO:0010906,GO:0042802,GO:0043410,GO:0051897,GO:0090331,GO:2000860" protein binding|collagen binding|collagen trimer|extracellular space|integral component of plasma membrane|positive regulation of cytosolic calcium ion concentration|negative regulation of platelet activation|positive regulation of gene expression|regulation of glucose metabolic process|identical protein binding|positive regulation of MAPK cascade|positive regulation of protein kinase B signaling|negative regulation of platelet aggregation|positive regulation of aldosterone secretion C1QTNF12 10.04747816 11.44455271 8.650403604 0.755853359 -0.403821727 0.795727704 1 0.559317531 0.415687684 388581 C1q and TNF related 12 "GO:0005179,GO:0005576,GO:0005615,GO:0007165,GO:0035774,GO:0045721,GO:0046324,GO:0046326,GO:0046628,GO:0050728,GO:0051897" hormone activity|extracellular region|extracellular space|signal transduction|positive regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of gluconeogenesis|regulation of glucose import|positive regulation of glucose import|positive regulation of insulin receptor signaling pathway|negative regulation of inflammatory response|positive regulation of protein kinase B signaling C1QTNF2 100.732677 70.74814402 130.71721 1.847641543 0.88568489 0.058342445 1 1.393760951 2.532078642 114898 C1q and TNF related 2 "GO:0005515,GO:0005576,GO:0005581,GO:0019216" protein binding|extracellular region|collagen trimer|regulation of lipid metabolic process C1QTNF3 17.77132435 24.96993318 10.57271552 0.423417854 -1.239845992 0.169159272 1 0.353193597 0.147045984 114899 C1q and TNF related 3 "GO:0001819,GO:0003674,GO:0005515,GO:0005581,GO:0016020,GO:0032715,GO:0035356,GO:0042802,GO:0045444,GO:0045721,GO:0050728,GO:0070062,GO:0070165,GO:0071638,GO:1901223" positive regulation of cytokine production|molecular_function|protein binding|collagen trimer|membrane|negative regulation of interleukin-6 production|cellular triglyceride homeostasis|identical protein binding|fat cell differentiation|negative regulation of gluconeogenesis|negative regulation of inflammatory response|extracellular exosome|positive regulation of adiponectin secretion|negative regulation of monocyte chemotactic protein-1 production|negative regulation of NIK/NF-kappaB signaling C1QTNF6 95.38656862 119.6475965 71.12554074 0.594458584 -0.750351795 0.114542934 1 0.724047207 0.423213647 114904 C1q and TNF related 6 "GO:0005515,GO:0005581,GO:0005615,GO:0042802" protein binding|collagen trimer|extracellular space|identical protein binding C1R 343.5466301 364.1448589 322.9484012 0.886867941 -0.173208799 0.571034881 1 7.448732024 6.495498472 715 complement C1r "GO:0004252,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0006955,GO:0006956,GO:0006958,GO:0008236,GO:0030449,GO:0031638,GO:0042802,GO:0045087,GO:0070062,GO:0072562" "serine-type endopeptidase activity|calcium ion binding|protein binding|extracellular region|extracellular space|immune response|complement activation|complement activation, classical pathway|serine-type peptidase activity|regulation of complement activation|zymogen activation|identical protein binding|innate immune response|extracellular exosome|blood microparticle" "hsa04145,hsa04610,hsa05133,hsa05150,hsa05171,hsa05322" Phagosome|Complement and coagulation cascades|Pertussis|Staphylococcus aureus infection|Coronavirus disease - COVID-19|Systemic lupus erythematosus C1RL 401.2354947 415.1251392 387.3458503 0.933082133 -0.099924018 0.736041305 1 6.028426044 5.530889595 51279 complement C1r subcomponent like "GO:0004252,GO:0005615,GO:0006958,GO:0031638,GO:0045087,GO:0070062,GO:0072562" "serine-type endopeptidase activity|extracellular space|complement activation, classical pathway|zymogen activation|innate immune response|extracellular exosome|blood microparticle" C1S 130.4140408 156.0620824 104.7659992 0.671309761 -0.574949476 0.177889981 1 2.846461554 1.878881814 716 complement C1s "GO:0004252,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0006508,GO:0006956,GO:0006958,GO:0030449,GO:0042802,GO:0045087,GO:0072562" "serine-type endopeptidase activity|calcium ion binding|protein binding|extracellular region|extracellular space|proteolysis|complement activation|complement activation, classical pathway|regulation of complement activation|identical protein binding|innate immune response|blood microparticle" "hsa04610,hsa05133,hsa05150,hsa05171,hsa05322" Complement and coagulation cascades|Pertussis|Staphylococcus aureus infection|Coronavirus disease - COVID-19|Systemic lupus erythematosus C1orf109 367.2880654 381.8318949 352.7442358 0.923820772 -0.11431511 0.706072155 1 6.15267707 5.588857324 54955 chromosome 1 open reading frame 109 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829" protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol C1orf112 555.2922056 535.8131496 574.7712617 1.072708391 0.101257942 0.70945974 1 5.996092055 6.324426478 55732 chromosome 1 open reading frame 112 GO:0005515 protein binding C1orf115 716.0027807 641.9353656 790.0701958 1.230762843 0.299552795 0.241170101 1 11.85019392 14.34072185 79762 chromosome 1 open reading frame 115 "GO:0016021,GO:0097731" integral component of membrane|9+0 non-motile cilium C1orf116 26.02543832 14.56579436 37.48508228 2.573500721 1.363732187 0.079272961 1 0.141284928 0.357512563 79098 chromosome 1 open reading frame 116 "GO:0003674,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0070062" molecular_function|protein binding|cytoplasm|cytosol|plasma membrane|biological_process|extracellular exosome C1orf122 281.1117363 264.2651262 297.9583464 1.127497792 0.173124609 0.59737227 1 11.79209372 13.07307645 127687 chromosome 1 open reading frame 122 C1orf131 127.0946543 144.6175297 109.571779 0.757665957 -0.400366168 0.3555169 1 5.397183052 4.020833601 128061 chromosome 1 open reading frame 131 "GO:0003723,GO:0005694" RNA binding|chromosome C1orf159 307.330289 296.5179566 318.1426214 1.072928686 0.101554188 0.753376573 1 6.506833209 6.864544265 54991 chromosome 1 open reading frame 159 GO:0016021 integral component of membrane C1orf162 37.3907331 35.37407201 39.4073942 1.114019166 0.155774053 0.853230817 1 0.263041551 0.288129813 128346 chromosome 1 open reading frame 162 GO:0016021 integral component of membrane C1orf174 539.8099147 495.2370081 584.3828212 1.180006364 0.23879464 0.375656994 1 6.211489757 7.206946556 339448 chromosome 1 open reading frame 174 "GO:0005515,GO:0005654" protein binding|nucleoplasm C1orf198 419.2647145 396.3976893 442.1317398 1.11537416 0.157527754 0.585671103 1 4.875551078 5.347065058 84886 chromosome 1 open reading frame 198 GO:0005829 cytosol C1orf21 988.3747946 929.0895972 1047.659992 1.127619979 0.173280945 0.482766374 1 4.817235423 5.34111356 81563 chromosome 1 open reading frame 21 GO:0005515 protein binding C1orf216 356.0221502 313.1645787 398.8797217 1.27370638 0.34903274 0.24364817 1 5.499512337 6.88754871 127703 chromosome 1 open reading frame 216 GO:0005515 protein binding C1orf226 158.654285 140.4558742 176.8526959 1.259133496 0.332431249 0.407006494 1 1.73797168 2.151719479 400793 chromosome 1 open reading frame 226 C1orf35 307.29066 295.4775427 319.1037774 1.079959494 0.110977202 0.730294663 1 12.2241034 12.98062669 79169 chromosome 1 open reading frame 35 "GO:0003723,GO:0005515,GO:0005576,GO:0034774,GO:0043312,GO:1904813" RNA binding|protein binding|extracellular region|secretory granule lumen|neutrophil degranulation|ficolin-1-rich granule lumen C1orf43 3171.398091 3319.9607 3022.835482 0.910503393 -0.135263701 0.568508371 1 69.83847091 62.52410291 25912 chromosome 1 open reading frame 43 "GO:0005739,GO:0005794,GO:0006909,GO:0016021" mitochondrion|Golgi apparatus|phagocytosis|integral component of membrane C1orf50 213.1722182 209.1231904 217.2212461 1.038723853 0.054812161 0.890527253 1 2.344647126 2.394687091 79078 chromosome 1 open reading frame 50 "GO:0005515,GO:0042802" protein binding|identical protein binding C1orf52 1111.788371 1065.383816 1158.192927 1.08711331 0.120502321 0.62288889 1 6.254958873 6.686062783 148423 chromosome 1 open reading frame 52 "GO:0003723,GO:0005654" RNA binding|nucleoplasm C1orf53 17.97449958 17.687036 18.26196316 1.032505568 0.046149562 1 1 1.573207674 1.597164458 388722 chromosome 1 open reading frame 53 C1orf54 3.923881751 2.080827765 5.766935736 2.771462315 1.470647391 0.503574097 1 0.133313269 0.363290077 79630 chromosome 1 open reading frame 54 GO:0005576 extracellular region C1orf56 119.8067267 142.5367019 97.07675156 0.681064949 -0.55413571 0.207731326 1 3.648403746 2.443220148 54964 chromosome 1 open reading frame 56 "GO:0003674,GO:0005515,GO:0005575,GO:0005576,GO:0042127" molecular_function|protein binding|cellular_component|extracellular region|regulation of cell population proliferation C1orf74 237.4338605 227.8506403 247.0170807 1.08411844 0.11652238 0.742315159 1 2.596065308 2.767346391 148304 chromosome 1 open reading frame 74 GO:0005515 protein binding C2 5.04355356 6.242483296 3.844623824 0.615880514 -0.699277611 0.760739355 1 0.090776529 0.054971959 717 complement C2 "GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0006508,GO:0006956,GO:0006958,GO:0007584,GO:0030449,GO:0045087,GO:0046872,GO:0070062,GO:2000427" "serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|proteolysis|complement activation|complement activation, classical pathway|response to nutrient|regulation of complement activation|innate immune response|metal ion binding|extracellular exosome|positive regulation of apoptotic cell clearance" "hsa04610,hsa05133,hsa05150,hsa05171,hsa05322" Complement and coagulation cascades|Pertussis|Staphylococcus aureus infection|Coronavirus disease - COVID-19|Systemic lupus erythematosus C20orf203 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.029529326 0.026823314 284805 chromosome 20 open reading frame 203 GO:0005737 cytoplasm C20orf204 6.564545421 8.323311061 4.80577978 0.577387982 -0.792387015 0.636893371 1 0.165314408 0.093853317 284739 chromosome 20 open reading frame 204 C20orf27 916.4321369 869.7860059 963.0782679 1.107258868 0.146992551 0.555203789 1 26.06338042 28.37599433 54976 chromosome 20 open reading frame 27 "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process C20orf96 233.8270105 234.0931236 233.5608973 0.997726433 -0.003283798 1 1 7.907037824 7.757047901 140680 chromosome 20 open reading frame 96 C21orf58 355.8730808 384.9531366 326.793025 0.848916385 -0.236305634 0.43181394 1 4.125349676 3.443474418 54058 chromosome 21 open reading frame 58 C21orf91 234.7730752 271.5480234 197.9981269 0.729145896 -0.455720579 0.183377373 1 2.685696613 1.925495757 54149 chromosome 21 open reading frame 91 "GO:0021895,GO:0060999" cerebral cortex neuron differentiation|positive regulation of dendritic spine development C22orf23 14.05061783 15.60620824 12.49502743 0.800644669 -0.320765987 0.805610112 1 0.384521999 0.302713777 84645 chromosome 22 open reading frame 23 "GO:0003674,GO:0005515,GO:0005575,GO:0008150" molecular_function|protein binding|cellular_component|biological_process C22orf39 572.0476538 597.1975686 546.897739 0.915773552 -0.126937194 0.636394277 1 8.567563612 7.714656848 128977 chromosome 22 open reading frame 39 GO:0005515 protein binding C2CD2 2051.125319 1842.572986 2259.677653 1.22637077 0.294395217 0.21338138 1 12.50759778 15.08227573 25966 C2 calcium dependent domain containing 2 "GO:0005634,GO:0005829,GO:0016021" nucleus|cytosol|integral component of membrane C2CD2L 445.1266066 419.2867947 470.9664184 1.123256025 0.167686801 0.554784916 1 3.356317027 3.706917423 9854 C2CD2 like "GO:0005515,GO:0005789,GO:0008526,GO:0015914,GO:0016021,GO:0032541,GO:0035091,GO:0035774,GO:0043559,GO:0098592,GO:0120009,GO:0140268" protein binding|endoplasmic reticulum membrane|phosphatidylinositol transfer activity|phospholipid transport|integral component of membrane|cortical endoplasmic reticulum|phosphatidylinositol binding|positive regulation of insulin secretion involved in cellular response to glucose stimulus|insulin binding|cytoplasmic side of apical plasma membrane|intermembrane lipid transfer|endoplasmic reticulum-plasma membrane contact site C2CD3 695.1435845 826.0886228 564.1985462 0.68297581 -0.550093614 0.031945933 0.912026363 4.895273319 3.287406771 26005 C2 domain containing 3 centriole elongation regulator "GO:0001701,GO:0001947,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0007420,GO:0008589,GO:0016485,GO:0021915,GO:0021997,GO:0030162,GO:0034451,GO:0036064,GO:0042733,GO:0061511,GO:0071539,GO:0097711,GO:1905515" in utero embryonic development|heart looping|protein binding|centrosome|centriole|cytosol|brain development|regulation of smoothened signaling pathway|protein processing|neural tube development|neural plate axis specification|regulation of proteolysis|centriolar satellite|ciliary basal body|embryonic digit morphogenesis|centriole elongation|protein localization to centrosome|ciliary basal body-plasma membrane docking|non-motile cilium assembly C2CD4C 4.845408743 1.040413883 8.650403604 8.314386946 3.055609892 0.118982446 1 0.017859433 0.146005452 126567 C2 calcium dependent domain containing 4C GO:0005829 cytosol C2CD5 1342.374639 1391.033361 1293.715917 0.930039461 -0.104636165 0.664890097 1 15.04293695 13.75641248 9847 C2 calcium dependent domain containing 5 "GO:0005509,GO:0005544,GO:0005829,GO:0005886,GO:0005938,GO:0010828,GO:0030659,GO:0031340,GO:0032587,GO:0032869,GO:0034451,GO:0038028,GO:0065002,GO:0072659,GO:0090314" calcium ion binding|calcium-dependent phospholipid binding|cytosol|plasma membrane|cell cortex|positive regulation of glucose transmembrane transport|cytoplasmic vesicle membrane|positive regulation of vesicle fusion|ruffle membrane|cellular response to insulin stimulus|centriolar satellite|insulin receptor signaling pathway via phosphatidylinositol 3-kinase|intracellular protein transmembrane transport|protein localization to plasma membrane|positive regulation of protein targeting to membrane C2orf15 12.12830592 15.60620824 8.650403604 0.554292463 -0.851280704 0.441608596 1 0.483386332 0.263453831 150590 chromosome 2 open reading frame 15 "GO:0003723,GO:0005515" RNA binding|protein binding C2orf42 118.0529915 121.7284243 114.3775588 0.93961258 -0.089862066 0.856839559 1 1.9608881 1.8116438 54980 chromosome 2 open reading frame 42 "GO:0005515,GO:0005634,GO:0005654" protein binding|nucleus|nucleoplasm C2orf49 789.0550494 730.3705456 847.7395532 1.160697893 0.214992515 0.39487943 1 3.377103938 3.854204923 79074 chromosome 2 open reading frame 49 "GO:0003674,GO:0005515,GO:0005634,GO:0005654,GO:0006388,GO:0008150,GO:0048598,GO:0072669" "molecular_function|protein binding|nucleus|nucleoplasm|tRNA splicing, via endonucleolytic cleavage and ligation|biological_process|embryonic morphogenesis|tRNA-splicing ligase complex" C2orf50 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.023010765 0.013934735 130813 chromosome 2 open reading frame 50 GO:0005515 protein binding C2orf66 5.083182523 7.282897178 2.883467868 0.395923188 -1.336707531 0.4551609 1 0.291579023 0.113511116 401027 chromosome 2 open reading frame 66 GO:0005576 extracellular region C2orf68 629.181713 633.6120545 624.7513714 0.986015602 -0.02031762 0.944430249 1 7.365434725 7.140906564 388969 chromosome 2 open reading frame 68 GO:0005515 protein binding C2orf69 667.053024 668.9861265 665.1199215 0.994220799 -0.00836181 0.980693375 1 9.672869149 9.456040768 205327 chromosome 2 open reading frame 69 GO:0005576 extracellular region C2orf74 32.46606643 32.25283036 32.6793025 1.013222782 0.018951421 1 1 1.186267594 1.18184029 339804 chromosome 2 open reading frame 74 "GO:0005515,GO:0016021" protein binding|integral component of membrane C2orf76 56.64845077 48.89945248 64.39744905 1.316935994 0.397185229 0.500453305 1 0.580960353 0.752284895 130355 chromosome 2 open reading frame 76 GO:0005515 protein binding C2orf78 12.32645074 20.80827765 3.844623824 0.184764154 -2.436243205 0.028294287 0.877967194 0.346057817 0.062869146 388960 chromosome 2 open reading frame 78 C2orf81 31.98045804 44.73779695 19.22311912 0.42968408 -1.21865177 0.08655503 1 1.035823861 0.437629261 388963 chromosome 2 open reading frame 81 C2orf88 32.38177809 42.65696919 22.10658699 0.518240921 -0.948305158 0.180212481 1 0.406667389 0.207225038 84281 chromosome 2 open reading frame 88 "GO:0005515,GO:0005886,GO:0034237" protein binding|plasma membrane|protein kinase A regulatory subunit binding C2orf92 7.604959303 10.40413883 4.80577978 0.461910386 -1.11431511 0.425432296 1 0.188411865 0.085573078 728537 chromosome 2 open reading frame 92 GO:0016021 integral component of membrane C3 6914.768609 9014.145879 4815.39134 0.53420384 -0.904537749 0.000235424 0.065702549 91.96490122 48.30591274 718 complement C3 "GO:0001798,GO:0001934,GO:0001970,GO:0004866,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005886,GO:0006631,GO:0006954,GO:0006955,GO:0006956,GO:0006957,GO:0006958,GO:0007165,GO:0007186,GO:0009617,GO:0009986,GO:0010575,GO:0010828,GO:0010866,GO:0010884,GO:0010951,GO:0016322,GO:0030449,GO:0031715,GO:0032991,GO:0034774,GO:0035578,GO:0035846,GO:0043312,GO:0043687,GO:0044267,GO:0045745,GO:0045766,GO:0048260,GO:0050776,GO:0060100,GO:0070062,GO:0072562,GO:0097242,GO:0097278,GO:0150062,GO:0150064,GO:1905114,GO:2000427" "positive regulation of type IIa hypersensitivity|positive regulation of protein phosphorylation|positive regulation of activation of membrane attack complex|endopeptidase inhibitor activity|signaling receptor binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|plasma membrane|fatty acid metabolic process|inflammatory response|immune response|complement activation|complement activation, alternative pathway|complement activation, classical pathway|signal transduction|G protein-coupled receptor signaling pathway|response to bacterium|cell surface|positive regulation of vascular endothelial growth factor production|positive regulation of glucose transmembrane transport|regulation of triglyceride biosynthetic process|positive regulation of lipid storage|negative regulation of endopeptidase activity|neuron remodeling|regulation of complement activation|C5L2 anaphylatoxin chemotactic receptor binding|protein-containing complex|secretory granule lumen|azurophil granule lumen|oviduct epithelium development|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|positive regulation of G protein-coupled receptor signaling pathway|positive regulation of angiogenesis|positive regulation of receptor-mediated endocytosis|regulation of immune response|positive regulation of phagocytosis, engulfment|extracellular exosome|blood microparticle|amyloid-beta clearance|complement-dependent cytotoxicity|complement-mediated synapse pruning|vertebrate eye-specific patterning|cell surface receptor signaling pathway involved in cell-cell signaling|positive regulation of apoptotic cell clearance" "hsa04080,hsa04145,hsa04610,hsa05131,hsa05133,hsa05134,hsa05140,hsa05142,hsa05150,hsa05152,hsa05167,hsa05168,hsa05171,hsa05203,hsa05322" Neuroactive ligand-receptor interaction|Phagosome|Complement and coagulation cascades|Shigellosis|Pertussis|Legionellosis|Leishmaniasis|Chagas disease|Staphylococcus aureus infection|Tuberculosis|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Coronavirus disease - COVID-19|Viral carcinogenesis|Systemic lupus erythematosus C3AR1 23.85529179 33.29324424 14.41733934 0.433040987 -1.207424514 0.130217901 1 0.508965699 0.216714863 719 complement C3a receptor 1 "GO:0002430,GO:0004875,GO:0004876,GO:0004930,GO:0005886,GO:0005887,GO:0006935,GO:0006954,GO:0007186,GO:0007200,GO:0007204,GO:0008015,GO:0010575,GO:0010759,GO:0030449,GO:0035577,GO:0035579,GO:0043312,GO:0045766,GO:0051482,GO:0090023" complement receptor mediated signaling pathway|complement receptor activity|complement component C3a receptor activity|G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|chemotaxis|inflammatory response|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|blood circulation|positive regulation of vascular endothelial growth factor production|positive regulation of macrophage chemotaxis|regulation of complement activation|azurophil granule membrane|specific granule membrane|neutrophil degranulation|positive regulation of angiogenesis|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|positive regulation of neutrophil chemotaxis "hsa04080,hsa04610,hsa05150,hsa05171" Neuroactive ligand-receptor interaction|Complement and coagulation cascades|Staphylococcus aureus infection|Coronavirus disease - COVID-19 C3orf14 250.0477748 230.9718819 269.1236677 1.165179352 0.220552041 0.515439941 1 7.752543919 8.881947334 57415 chromosome 3 open reading frame 14 C3orf18 252.5594908 259.0630568 246.0559247 0.949791637 -0.074317042 0.834683731 1 3.489580818 3.258913106 51161 chromosome 3 open reading frame 18 GO:0016021 integral component of membrane C3orf20 6.083967443 8.323311061 3.844623824 0.461910386 -1.11431511 0.492415049 1 0.079095408 0.035923627 84077 chromosome 3 open reading frame 20 "GO:0005737,GO:0016021" cytoplasm|integral component of membrane C3orf33 82.10902277 73.86938567 90.34865986 1.223086656 0.290526622 0.57488234 1 1.192460178 1.434076407 285315 chromosome 3 open reading frame 33 "GO:0005515,GO:0005615,GO:0016021,GO:0051090,GO:0070373" protein binding|extracellular space|integral component of membrane|regulation of DNA-binding transcription factor activity|negative regulation of ERK1 and ERK2 cascade C3orf38 726.1590849 681.4710931 770.8470767 1.13115154 0.17779222 0.48740734 1 15.05956925 16.74960308 285237 chromosome 3 open reading frame 38 "GO:0003674,GO:0005634,GO:0006915,GO:0043065" molecular_function|nucleus|apoptotic process|positive regulation of apoptotic process C3orf52 318.5420983 300.6796121 336.4045846 1.118814083 0.161970319 0.605820818 1 7.17332064 7.891314406 79669 chromosome 3 open reading frame 52 "GO:0005515,GO:0005789,GO:0016021" protein binding|endoplasmic reticulum membrane|integral component of membrane C3orf62 134.7788716 157.1024963 112.4552469 0.715808148 -0.48235513 0.253865559 1 2.236998795 1.574467013 375341 chromosome 3 open reading frame 62 GO:0005515 protein binding C3orf80 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.059661508 0.018064747 401097 chromosome 3 open reading frame 80 GO:0016021 integral component of membrane C4A 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.030961883 0.046874324 720 complement C4A (Rodgers blood group) "GO:0001849,GO:0004866,GO:0005576,GO:0005615,GO:0005788,GO:0005886,GO:0006954,GO:0006956,GO:0006958,GO:0010951,GO:0030424,GO:0030425,GO:0030449,GO:0043025,GO:0043687,GO:0044267,GO:0045087,GO:0045202,GO:0070062,GO:0072562,GO:2000427" "complement component C1q complex binding|endopeptidase inhibitor activity|extracellular region|extracellular space|endoplasmic reticulum lumen|plasma membrane|inflammatory response|complement activation|complement activation, classical pathway|negative regulation of endopeptidase activity|axon|dendrite|regulation of complement activation|neuronal cell body|post-translational protein modification|cellular protein metabolic process|innate immune response|synapse|extracellular exosome|blood microparticle|positive regulation of apoptotic cell clearance" "hsa04610,hsa05133,hsa05150,hsa05171,hsa05322" Complement and coagulation cascades|Pertussis|Staphylococcus aureus infection|Coronavirus disease - COVID-19|Systemic lupus erythematosus C4orf19 50.921144 49.93986637 51.90242162 1.039298368 0.055609892 0.962009428 1 0.629326773 0.643113508 55286 chromosome 4 open reading frame 19 "GO:0005515,GO:0005654,GO:0030054" protein binding|nucleoplasm|cell junction C4orf3 882.5155045 660.6628155 1104.368193 1.671606404 0.741235191 0.002983774 0.354809602 12.27658782 20.17822125 401152 chromosome 4 open reading frame 3 GO:0016021 integral component of membrane C4orf33 417.4317214 373.5085839 461.3548589 1.235192118 0.304735452 0.287536545 1 5.004636365 6.078245226 132321 chromosome 4 open reading frame 33 GO:0005515 protein binding C4orf36 16.01255871 16.64662212 15.3784953 0.923820772 -0.11431511 0.976849093 1 0.409212173 0.37171274 132989 chromosome 4 open reading frame 36 C4orf46 841.2889796 802.1591035 880.4188557 1.097561384 0.134301628 0.593844479 1 12.71828789 13.725515 201725 chromosome 4 open reading frame 46 "GO:0005515,GO:0005737" protein binding|cytoplasm C4orf47 19.45586248 18.72744989 20.18427508 1.0777909 0.108077311 0.966287111 1 0.302955314 0.321058569 441054 chromosome 4 open reading frame 47 "GO:0005813,GO:0005881,GO:0097731" centrosome|cytoplasmic microtubule|9+0 non-motile cilium C4orf48 179.5122525 158.1429102 200.8815948 1.270253561 0.345116509 0.365607815 1 4.586845903 5.728959469 401115 chromosome 4 open reading frame 48 GO:0005576 extracellular region C5 71.25890451 66.58648849 75.93132052 1.140341265 0.189465638 0.739912147 1 0.596741983 0.669102438 727 complement C5 "GO:0000187,GO:0001701,GO:0004866,GO:0005102,GO:0005515,GO:0005576,GO:0005579,GO:0005615,GO:0006935,GO:0006954,GO:0006957,GO:0006958,GO:0007166,GO:0007186,GO:0008009,GO:0010575,GO:0010760,GO:0010951,GO:0019835,GO:0030449,GO:0032722,GO:0045766,GO:0060326,GO:0070062" "activation of MAPK activity|in utero embryonic development|endopeptidase inhibitor activity|signaling receptor binding|protein binding|extracellular region|membrane attack complex|extracellular space|chemotaxis|inflammatory response|complement activation, alternative pathway|complement activation, classical pathway|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|chemokine activity|positive regulation of vascular endothelial growth factor production|negative regulation of macrophage chemotaxis|negative regulation of endopeptidase activity|cytolysis|regulation of complement activation|positive regulation of chemokine production|positive regulation of angiogenesis|cell chemotaxis|extracellular exosome" "hsa04080,hsa04610,hsa05020,hsa05133,hsa05150,hsa05168,hsa05171,hsa05322" Neuroactive ligand-receptor interaction|Complement and coagulation cascades|Prion disease|Pertussis|Staphylococcus aureus infection|Herpes simplex virus 1 infection|Coronavirus disease - COVID-19|Systemic lupus erythematosus C5AR1 3.562190663 5.202069413 1.922311912 0.369528309 -1.436243205 0.543489417 1 0.120654013 0.043839002 728 complement C5a receptor 1 "GO:0000187,GO:0001774,GO:0001856,GO:0002430,GO:0004875,GO:0004878,GO:0004930,GO:0005886,GO:0005887,GO:0006915,GO:0006935,GO:0006954,GO:0006955,GO:0006968,GO:0007165,GO:0007186,GO:0007200,GO:0007202,GO:0007204,GO:0007606,GO:0009986,GO:0010575,GO:0010759,GO:0016323,GO:0021534,GO:0030449,GO:0030593,GO:0030667,GO:0031100,GO:0032494,GO:0032496,GO:0038178,GO:0042789,GO:0043312,GO:0043524,GO:0045177,GO:0045766,GO:0048143,GO:0050679,GO:0050830,GO:0050890,GO:0070374,GO:0090023,GO:0097242,GO:0099172,GO:1902947" activation of MAPK activity|microglial cell activation|complement component C5a binding|complement receptor mediated signaling pathway|complement receptor activity|complement component C5a receptor activity|G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|apoptotic process|chemotaxis|inflammatory response|immune response|cellular defense response|signal transduction|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|activation of phospholipase C activity|positive regulation of cytosolic calcium ion concentration|sensory perception of chemical stimulus|cell surface|positive regulation of vascular endothelial growth factor production|positive regulation of macrophage chemotaxis|basolateral plasma membrane|cell proliferation in hindbrain|regulation of complement activation|neutrophil chemotaxis|secretory granule membrane|animal organ regeneration|response to peptidoglycan|response to lipopolysaccharide|complement component C5a signaling pathway|mRNA transcription by RNA polymerase II|neutrophil degranulation|negative regulation of neuron apoptotic process|apical part of cell|positive regulation of angiogenesis|astrocyte activation|positive regulation of epithelial cell proliferation|defense response to Gram-positive bacterium|cognition|positive regulation of ERK1 and ERK2 cascade|positive regulation of neutrophil chemotaxis|amyloid-beta clearance|presynapse organization|regulation of tau-protein kinase activity "hsa04080,hsa04610,hsa05150,hsa05171" Neuroactive ligand-receptor interaction|Complement and coagulation cascades|Staphylococcus aureus infection|Coronavirus disease - COVID-19 C5orf15 1349.020285 1098.67706 1599.363511 1.45571758 0.541730489 0.024189771 0.850373039 26.79816061 38.35776472 56951 chromosome 5 open reading frame 15 GO:0016021 integral component of membrane C5orf22 677.6848758 721.0068207 634.362931 0.879829306 -0.184704438 0.475064838 1 9.894268158 8.559596235 55322 chromosome 5 open reading frame 22 GO:0005515 protein binding C5orf24 1899.455178 1961.180169 1837.730188 0.937053218 -0.09379711 0.693430658 1 18.00526081 16.58955939 134553 chromosome 5 open reading frame 24 GO:0005515 protein binding C5orf34 408.1271327 406.8018281 409.4524373 1.006515726 0.009369713 0.983679236 1 4.994310075 4.942734075 375444 chromosome 5 open reading frame 34 C5orf46 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.045059831 0.020465316 389336 chromosome 5 open reading frame 46 "GO:0003674,GO:0005515,GO:0008150,GO:0070062" molecular_function|protein binding|biological_process|extracellular exosome C5orf51 203.1197097 210.1636043 196.075815 0.932967512 -0.100101251 0.793330546 1 2.077045425 1.905389178 285636 chromosome 5 open reading frame 51 "GO:0005654,GO:0005829" nucleoplasm|cytosol C5orf63 69.25230425 76.99062732 61.51398118 0.798980127 -0.323768476 0.555888821 1 0.634375216 0.498371689 401207 chromosome 5 open reading frame 63 GO:0055114 oxidation-reduction process C6orf120 675.2473874 707.4814402 643.0133346 0.908876612 -0.137843645 0.595621722 1 8.886087119 7.941209863 387263 chromosome 6 open reading frame 120 "GO:0005576,GO:0006915,GO:0035578,GO:0043312" extracellular region|apoptotic process|azurophil granule lumen|neutrophil degranulation C6orf132 178.7492413 163.3449796 194.1535031 1.188610165 0.249275624 0.517635182 1 1.365297 1.595650433 647024 chromosome 6 open reading frame 132 C6orf136 180.9439256 183.1128433 178.7750078 0.976310588 -0.034587917 0.942723441 1 6.616381789 6.351550209 221545 chromosome 6 open reading frame 136 C6orf141 293.2350118 292.356301 294.1137225 1.006011232 0.008646413 0.990542395 1 5.582296407 5.521879192 135398 chromosome 6 open reading frame 141 "GO:0001835,GO:0005515" blastocyst hatching|protein binding C6orf163 4.082397604 6.242483296 1.922311912 0.307940257 -1.699277611 0.406294648 1 0.24787936 0.075054721 206412 chromosome 6 open reading frame 163 "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process C6orf226 21.81912341 17.687036 25.95121081 1.467244755 0.553109551 0.525459936 1 1.694658176 2.444870474 441150 chromosome 6 open reading frame 226 GO:0005515 protein binding C6orf47 198.9781758 151.9004269 246.0559247 1.61985012 0.695860331 0.056232234 1 3.267491576 5.204278003 57827 chromosome 6 open reading frame 47 GO:0005515 protein binding C6orf52 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.104632494 0.03168139 347744 chromosome 6 open reading frame 52 C6orf58 8.645373186 12.48496659 4.80577978 0.384925322 -1.377349516 0.279195182 1 0.553865104 0.209629145 352999 chromosome 6 open reading frame 58 "GO:0005515,GO:0005615,GO:0007275,GO:0070062" protein binding|extracellular space|multicellular organism development|extracellular exosome C6orf62 1939.348795 1847.775056 2030.922535 1.099117844 0.136346076 0.5655577 1 19.1591915 20.70582864 81688 chromosome 6 open reading frame 62 "GO:0003674,GO:0008150" molecular_function|biological_process C6orf89 2025.61763 2232.728192 1818.507069 0.814477586 -0.296053097 0.210801997 1 14.04486092 11.24780449 221477 chromosome 6 open reading frame 89 "GO:0000139,GO:0005515,GO:0005730,GO:0005737,GO:0005886,GO:0016021,GO:0030496,GO:0042060,GO:0045787,GO:0050673,GO:1901727" Golgi membrane|protein binding|nucleolus|cytoplasm|plasma membrane|integral component of membrane|midbody|wound healing|positive regulation of cell cycle|epithelial cell proliferation|positive regulation of histone deacetylase activity C7orf25 290.7874625 303.8008537 277.7740713 0.914329462 -0.129213986 0.691685708 1 3.435019746 3.088183731 79020 chromosome 7 open reading frame 25 GO:0005515 protein binding C7orf26 335.476184 316.2858203 354.6665478 1.121348239 0.165234383 0.59228313 1 6.550094265 7.222029104 79034 chromosome 7 open reading frame 26 C7orf31 236.7847058 248.658918 224.9104937 0.904493977 -0.144817198 0.679751348 1 3.572131746 3.176905715 136895 chromosome 7 open reading frame 31 "GO:0005515,GO:0005737,GO:0005813" protein binding|cytoplasm|centrosome C7orf50 885.8984432 812.5632423 959.2336441 1.180503368 0.239402157 0.336546757 1 9.425126454 10.94020839 84310 chromosome 7 open reading frame 50 "GO:0003723,GO:0005515" RNA binding|protein binding C7orf57 58.60536123 62.42483296 54.78588949 0.877629733 -0.188315691 0.763069657 1 2.050152986 1.769166784 136288 chromosome 7 open reading frame 57 C7orf61 17.7367258 11.44455271 24.0288989 2.099592663 1.070109461 0.240135862 1 0.618193061 1.276234118 402573 chromosome 7 open reading frame 61 GO:0005634 nucleus C8G 3.081612685 5.202069413 0.961155956 0.184764154 -2.436243205 0.338470402 1 0.315124726 0.057249458 733 complement C8 gamma chain "GO:0001848,GO:0005515,GO:0005576,GO:0005579,GO:0006957,GO:0006958,GO:0019835,GO:0019841,GO:0030449,GO:0044877,GO:0070062,GO:0072562" "complement binding|protein binding|extracellular region|membrane attack complex|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|retinol binding|regulation of complement activation|protein-containing complex binding|extracellular exosome|blood microparticle" "hsa04610,hsa05020,hsa05146,hsa05171,hsa05322" Complement and coagulation cascades|Prion disease|Amoebiasis|Coronavirus disease - COVID-19|Systemic lupus erythematosus C8orf33 1070.65681 1070.585885 1070.727735 1.000132497 0.000191141 1 1 20.81428089 20.46869377 65265 chromosome 8 open reading frame 33 GO:0005515 protein binding C8orf37 145.391216 158.1429102 132.6395219 0.838732016 -0.253718167 0.543890053 1 2.526885168 2.083914547 157657 chromosome 8 open reading frame 37 "GO:0001917,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0008594,GO:0030054,GO:0097546" photoreceptor inner segment|protein binding|cytoplasm|cytosol|plasma membrane|photoreceptor cell morphogenesis|cell junction|ciliary base C8orf44-SGK3 100.881132 99.87973273 101.8825313 1.020052102 0.028642844 0.974897507 1 1.179552504 1.183071005 100533105 C8orf44-SGK3 readthrough "GO:0001558,GO:0004672,GO:0004674,GO:0005246,GO:0005515,GO:0005524,GO:0005654,GO:0005769,GO:0005829,GO:0006468,GO:0015459,GO:0017080,GO:0017081,GO:0018105,GO:0030334,GO:0034220,GO:0035091,GO:0035556,GO:0042127,GO:0043231,GO:0051090,GO:0055037,GO:0106310,GO:0106311" regulation of cell growth|protein kinase activity|protein serine/threonine kinase activity|calcium channel regulator activity|protein binding|ATP binding|nucleoplasm|early endosome|cytosol|protein phosphorylation|potassium channel regulator activity|sodium channel regulator activity|chloride channel regulator activity|peptidyl-serine phosphorylation|regulation of cell migration|ion transmembrane transport|phosphatidylinositol binding|intracellular signal transduction|regulation of cell population proliferation|intracellular membrane-bounded organelle|regulation of DNA-binding transcription factor activity|recycling endosome|protein serine kinase activity|protein threonine kinase activity "hsa04068,hsa04151" FoxO signaling pathway|PI3K-Akt signaling pathway C8orf48 42.43428666 41.61655531 43.25201802 1.039298368 0.055609892 0.971779244 1 1.564083851 1.59834842 157773 chromosome 8 open reading frame 48 GO:0005515 protein binding C8orf58 195.8072444 169.5874629 222.0270258 1.309218394 0.388705777 0.290685882 1 4.402028796 5.666777439 541565 chromosome 8 open reading frame 58 C8orf76 22.26007242 16.64662212 27.87352272 1.674425149 0.743665885 0.375505823 1 0.678167655 1.116539235 84933 chromosome 8 open reading frame 76 C8orf82 214.7774984 200.7998793 228.7551175 1.139219397 0.188045616 0.602522908 1 4.365100003 4.88959341 414919 chromosome 8 open reading frame 82 C8orf88 3.884252787 1.040413883 6.728091692 6.466745402 2.693039812 0.222326747 1 0.041905643 0.26645842 100127983 chromosome 8 open reading frame 88 "GO:0005737,GO:0008190,GO:0045947" cytoplasm|eukaryotic initiation factor 4E binding|negative regulation of translational initiation C9orf116 77.30324299 73.86938567 80.7371003 1.092971054 0.128255193 0.825133868 1 5.840404958 6.276576116 138162 chromosome 9 open reading frame 116 "GO:0005515,GO:0005634,GO:0006974,GO:0007368,GO:0010468,GO:0071494" protein binding|nucleus|cellular response to DNA damage stimulus|determination of left/right symmetry|regulation of gene expression|cellular response to UV-C C9orf153 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.084512902 0 389766 chromosome 9 open reading frame 153 C9orf163 15.37346488 12.48496659 18.26196316 1.462716222 0.548649903 0.600554067 1 0.217887417 0.313374321 158055 chromosome 9 putative open reading frame 163 C9orf24 8.486857333 8.323311061 8.650403604 1.039298368 0.055609892 1 1 0.067930848 0.069419017 84688 chromosome 9 open reading frame 24 "GO:0002177,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0007283,GO:0030154,GO:0034622,GO:0043014,GO:0048471" manchette|protein binding|nucleus|nucleoplasm|cytosol|spermatogenesis|cell differentiation|cellular protein-containing complex assembly|alpha-tubulin binding|perinuclear region of cytoplasm C9orf40 593.0005848 478.590386 707.4107836 1.478113235 0.563756795 0.032523304 0.920517339 10.86409583 15.78964885 55071 chromosome 9 open reading frame 40 C9orf43 7.525701377 8.323311061 6.728091692 0.808343175 -0.306960188 0.918003413 1 0.171903953 0.136632123 257169 chromosome 9 open reading frame 43 GO:0005515 protein binding C9orf47 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.03442342 0.031268923 286223 chromosome 9 open reading frame 47 GO:0005576 extracellular region C9orf64 707.7285451 702.2793708 713.1777193 1.015518537 0.022216575 0.936689347 1 13.62390377 13.60381137 84267 chromosome 9 open reading frame 64 "GO:0003674,GO:0005515,GO:0005575,GO:0006400,GO:0008150,GO:0101030" molecular_function|protein binding|cellular_component|tRNA modification|biological_process|tRNA-guanine transglycosylation C9orf72 960.5855602 918.6854584 1002.485662 1.091217514 0.125938705 0.61207692 1 10.77550647 11.56166013 203228 C9orf72-SMCR8 complex subunit "GO:0000932,GO:0001933,GO:0005085,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005764,GO:0005768,GO:0005776,GO:0005829,GO:0006897,GO:0006914,GO:0010494,GO:0010506,GO:0016239,GO:0030425,GO:0031267,GO:0031965,GO:0032045,GO:0034063,GO:0043204,GO:0043231,GO:0044295,GO:0044304,GO:0048675,GO:0050790,GO:0090543,GO:0110053,GO:1902774,GO:1903432,GO:1990316,GO:2000785" P-body|negative regulation of protein phosphorylation|guanyl-nucleotide exchange factor activity|protein binding|extracellular space|nucleus|cytoplasm|lysosome|endosome|autophagosome|cytosol|endocytosis|autophagy|cytoplasmic stress granule|regulation of autophagy|positive regulation of macroautophagy|dendrite|small GTPase binding|nuclear membrane|guanyl-nucleotide exchange factor complex|stress granule assembly|perikaryon|intracellular membrane-bounded organelle|axonal growth cone|main axon|axon extension|regulation of catalytic activity|Flemming body|regulation of actin filament organization|late endosome to lysosome transport|regulation of TORC1 signaling|Atg1/ULK1 kinase complex|regulation of autophagosome assembly "hsa04140,hsa05014,hsa05022" Autophagy - animal|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases C9orf78 1020.934596 1026.888502 1014.98069 0.988403987 -0.016827265 0.94963012 1 29.99625179 29.15228879 51759 chromosome 9 open reading frame 78 "GO:0005515,GO:0005654,GO:0005681,GO:0005829,GO:0048024" "protein binding|nucleoplasm|spliceosomal complex|cytosol|regulation of mRNA splicing, via spliceosome" C9orf85 430.6595774 443.216314 418.1028409 0.943338112 -0.084153139 0.773341722 1 5.013488784 4.650274688 138241 chromosome 9 open reading frame 85 CA11 66.41852618 53.06110801 79.77594435 1.503473021 0.588298979 0.280445588 1 1.651180066 2.440963327 770 carbonic anhydrase 11 "GO:0004089,GO:0005576,GO:0006730,GO:0008270,GO:0016323,GO:0016836" carbonate dehydratase activity|extracellular region|one-carbon metabolic process|zinc ion binding|basolateral plasma membrane|hydro-lyase activity CA12 408.3051558 461.9437639 354.6665478 0.767769966 -0.38125397 0.184954227 1 4.042815622 3.052011971 771 carbonic anhydrase 12 "GO:0004089,GO:0005886,GO:0006730,GO:0008270,GO:0015701,GO:0016021,GO:0016836,GO:0055064" carbonate dehydratase activity|plasma membrane|one-carbon metabolic process|zinc ion binding|bicarbonate transport|integral component of membrane|hydro-lyase activity|chloride ion homeostasis hsa00910 Nitrogen metabolism CA13 270.9554321 224.7293987 317.1814655 1.411392846 0.497119602 0.127601156 1 3.087897778 4.285307641 377677 carbonic anhydrase 13 "GO:0004089,GO:0005515,GO:0005737,GO:0005829,GO:0006730,GO:0008270,GO:0015701,GO:0016836,GO:0043209,GO:0043231" carbonate dehydratase activity|protein binding|cytoplasm|cytosol|one-carbon metabolic process|zinc ion binding|bicarbonate transport|hydro-lyase activity|myelin sheath|intracellular membrane-bounded organelle hsa00910 Nitrogen metabolism CA2 77.38250091 75.95021343 78.81478839 1.037716483 0.053412336 0.944180819 1 2.594957299 2.6477691 760 carbonic anhydrase 2 "GO:0001822,GO:0004064,GO:0004089,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005902,GO:0006730,GO:0008270,GO:0009268,GO:0010043,GO:0015670,GO:0015701,GO:0016323,GO:0016836,GO:0030424,GO:0032849,GO:0038166,GO:0042475,GO:0043627,GO:0044070,GO:0045177,GO:0045672,GO:0045780,GO:0048545,GO:0051453,GO:0070062,GO:0071498,GO:2001150" kidney development|arylesterase activity|carbonate dehydratase activity|protein binding|cytoplasm|cytosol|plasma membrane|microvillus|one-carbon metabolic process|zinc ion binding|response to pH|response to zinc ion|carbon dioxide transport|bicarbonate transport|basolateral plasma membrane|hydro-lyase activity|axon|positive regulation of cellular pH reduction|angiotensin-activated signaling pathway|odontogenesis of dentin-containing tooth|response to estrogen|regulation of anion transport|apical part of cell|positive regulation of osteoclast differentiation|positive regulation of bone resorption|response to steroid hormone|regulation of intracellular pH|extracellular exosome|cellular response to fluid shear stress|positive regulation of dipeptide transmembrane transport "hsa00910,hsa04964,hsa04966,hsa04971,hsa04972,hsa04976" Nitrogen metabolism|Proximal tubule bicarbonate reclamation|Collecting duct acid secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion CA3 12.20756385 17.687036 6.728091692 0.380396788 -1.394423029 0.191425962 1 0.548474494 0.205146663 761 carbonic anhydrase 3 "GO:0004089,GO:0005515,GO:0005829,GO:0006730,GO:0006979,GO:0008270,GO:0009617,GO:0015701,GO:0016151,GO:0016311,GO:0016791,GO:0016836,GO:0045471" carbonate dehydratase activity|protein binding|cytosol|one-carbon metabolic process|response to oxidative stress|zinc ion binding|response to bacterium|bicarbonate transport|nickel cation binding|dephosphorylation|phosphatase activity|hydro-lyase activity|response to ethanol hsa00910 Nitrogen metabolism CA5B 215.6990254 199.7594655 231.6385854 1.159587531 0.213611726 0.551773051 1 1.559279732 1.777864873 11238 carbonic anhydrase 5B "GO:0004089,GO:0005737,GO:0005739,GO:0005759,GO:0006730,GO:0008270,GO:0009617,GO:0015701,GO:0016836" carbonate dehydratase activity|cytoplasm|mitochondrion|mitochondrial matrix|one-carbon metabolic process|zinc ion binding|response to bacterium|bicarbonate transport|hydro-lyase activity hsa00910 Nitrogen metabolism CA8 21.53165983 35.37407201 7.689247648 0.217369593 -2.201777951 0.010845039 0.620526829 0.196119801 0.041917118 767 carbonic anhydrase 8 "GO:0004089,GO:0005515,GO:0005737,GO:0006730,GO:0008270,GO:0016836,GO:0048015" carbonate dehydratase activity|protein binding|cytoplasm|one-carbon metabolic process|zinc ion binding|hydro-lyase activity|phosphatidylinositol-mediated signaling hsa00910 Nitrogen metabolism CA9 48.16662385 28.09117483 68.24207288 2.429306474 1.280544507 0.036909733 0.976206556 0.969711754 2.316307139 768 carbonic anhydrase 9 "GO:0002009,GO:0004089,GO:0005515,GO:0005730,GO:0005886,GO:0006730,GO:0008270,GO:0015701,GO:0016021,GO:0016323,GO:0016836,GO:0031528,GO:0033574,GO:0042493,GO:0046903,GO:0061418" morphogenesis of an epithelium|carbonate dehydratase activity|protein binding|nucleolus|plasma membrane|one-carbon metabolic process|zinc ion binding|bicarbonate transport|integral component of membrane|basolateral plasma membrane|hydro-lyase activity|microvillus membrane|response to testosterone|response to drug|secretion|regulation of transcription from RNA polymerase II promoter in response to hypoxia hsa00910 Nitrogen metabolism CAAP1 661.3653462 671.0669543 651.6637382 0.971086021 -0.042328997 0.875617298 1 12.16908256 11.61948069 79886 caspase activity and apoptosis inhibitor 1 "GO:0006915,GO:2001268" apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway CAB39 3643.799369 3635.206106 3652.392633 1.0047278 0.0068047 0.978441102 1 26.09337843 25.77804102 51719 calcium binding protein 39 "GO:0005515,GO:0005576,GO:0005829,GO:0007050,GO:0007165,GO:0010800,GO:0014823,GO:0016020,GO:0018105,GO:0019900,GO:0030018,GO:0030295,GO:0032147,GO:0034774,GO:0035556,GO:0043312,GO:0043539,GO:0070062,GO:0071476,GO:0071902,GO:0097066,GO:1901017,GO:1901380,GO:1902554,GO:1904813" protein binding|extracellular region|cytosol|cell cycle arrest|signal transduction|positive regulation of peptidyl-threonine phosphorylation|response to activity|membrane|peptidyl-serine phosphorylation|kinase binding|Z disc|protein kinase activator activity|activation of protein kinase activity|secretory granule lumen|intracellular signal transduction|neutrophil degranulation|protein serine/threonine kinase activator activity|extracellular exosome|cellular hypotonic response|positive regulation of protein serine/threonine kinase activity|response to thyroid hormone|negative regulation of potassium ion transmembrane transporter activity|negative regulation of potassium ion transmembrane transport|serine/threonine protein kinase complex|ficolin-1-rich granule lumen "hsa04150,hsa04152" mTOR signaling pathway|AMPK signaling pathway CAB39L 201.3710049 176.87036 225.8716497 1.277046361 0.352810901 0.332979877 1 2.257652725 2.834881967 81617 calcium binding protein 39 like "GO:0005515,GO:0005829,GO:0007050,GO:0035556,GO:0043539,GO:0071902" protein binding|cytosol|cell cycle arrest|intracellular signal transduction|protein serine/threonine kinase activator activity|positive regulation of protein serine/threonine kinase activity "hsa04150,hsa04152" mTOR signaling pathway|AMPK signaling pathway CABIN1 1269.233666 1224.56714 1313.900192 1.072950718 0.101583813 0.675558261 1 4.319424825 4.556977384 23523 calcineurin binding protein 1 "GO:0004864,GO:0005634,GO:0005654,GO:0005829,GO:0006336,GO:0007166,GO:0016235,GO:0031491,GO:0032515" protein phosphatase inhibitor activity|nucleus|nucleoplasm|cytosol|DNA replication-independent nucleosome assembly|cell surface receptor signaling pathway|aggresome|nucleosome binding|negative regulation of phosphoprotein phosphatase activity CABLES1 90.33798465 125.8900798 54.78588949 0.435188297 -1.200288333 0.013794964 0.6986894 1.21756473 0.521003267 91768 Cdk5 and Abl enzyme substrate 1 "GO:0005515,GO:0005634,GO:0005829,GO:0007049,GO:0051301,GO:0051726" protein binding|nucleus|cytosol|cell cycle|cell division|regulation of cell cycle CABLES2 426.2651785 416.1655531 436.364804 1.048536576 0.068377188 0.817344796 1 5.867897143 6.049747596 81928 Cdk5 and Abl enzyme substrate 2 "GO:0007049,GO:0051301,GO:0051726" cell cycle|cell division|regulation of cell cycle CABP1 6.406029567 4.161655531 8.650403604 2.078596736 1.055609892 0.509812894 1 0.036362133 0.074317445 9478 calcium binding protein 1 "GO:0000139,GO:0004857,GO:0005509,GO:0005515,GO:0005615,GO:0005856,GO:0005886,GO:0005938,GO:0007601,GO:0008139,GO:0014069,GO:0042308,GO:0043086,GO:0048306,GO:0048471,GO:0050896" Golgi membrane|enzyme inhibitor activity|calcium ion binding|protein binding|extracellular space|cytoskeleton|plasma membrane|cell cortex|visual perception|nuclear localization sequence binding|postsynaptic density|negative regulation of protein import into nucleus|negative regulation of catalytic activity|calcium-dependent protein binding|perinuclear region of cytoplasm|response to stimulus CABYR 354.7980684 369.3469283 340.2492084 0.92121846 -0.118384774 0.698902927 1 12.12261177 10.98069952 26256 calcium binding tyrosine phosphorylation regulated "GO:0003351,GO:0005509,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0017124,GO:0031514,GO:0035686,GO:0048240,GO:0097228,GO:0097229" epithelial cilium movement involved in extracellular fluid movement|calcium ion binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|SH3 domain binding|motile cilium|sperm fibrous sheath|sperm capacitation|sperm principal piece|sperm end piece CACFD1 158.4165112 134.2133909 182.6196316 1.360666253 0.444313243 0.265363679 1 1.51945736 2.03287797 11094 calcium channel flower domain containing 1 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021,GO:0016192" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane|vesicle-mediated transport CACHD1 188.0683069 193.5169822 182.6196316 0.943687885 -0.083618313 0.835265501 1 1.582780945 1.468656973 57685 cache domain containing 1 "GO:0005245,GO:0005891,GO:0070588" voltage-gated calcium channel activity|voltage-gated calcium channel complex|calcium ion transmembrane transport CACNA1G 8.006279355 8.323311061 7.689247648 0.923820772 -0.11431511 1 1 0.041228867 0.037450731 8913 calcium voltage-gated channel subunit alpha1 G "GO:0001518,GO:0005248,GO:0005737,GO:0005886,GO:0005891,GO:0007268,GO:0008332,GO:0010045,GO:0019228,GO:0034765,GO:0035725,GO:0042391,GO:0043005,GO:0045202,GO:0045956,GO:0060371,GO:0070509,GO:0070588,GO:0086002,GO:0086010,GO:0086015,GO:0086016,GO:0086018,GO:0086027,GO:0086045,GO:0086046,GO:0086056,GO:0086059,GO:0086091,GO:0097110" voltage-gated sodium channel complex|voltage-gated sodium channel activity|cytoplasm|plasma membrane|voltage-gated calcium channel complex|chemical synaptic transmission|low voltage-gated calcium channel activity|response to nickel cation|neuronal action potential|regulation of ion transmembrane transport|sodium ion transmembrane transport|regulation of membrane potential|neuron projection|synapse|positive regulation of calcium ion-dependent exocytosis|regulation of atrial cardiac muscle cell membrane depolarization|calcium ion import|calcium ion transmembrane transport|cardiac muscle cell action potential involved in contraction|membrane depolarization during action potential|SA node cell action potential|AV node cell action potential|SA node cell to atrial cardiac muscle cell signaling|AV node cell to bundle of His cell signaling|membrane depolarization during AV node cell action potential|membrane depolarization during SA node cell action potential|voltage-gated calcium channel activity involved in AV node cell action potential|voltage-gated calcium channel activity involved SA node cell action potential|regulation of heart rate by cardiac conduction|scaffold protein binding "hsa04010,hsa04020,hsa04713,hsa04925,hsa04927,hsa04929,hsa04930,hsa04934" MAPK signaling pathway|Calcium signaling pathway|Circadian entrainment|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|GnRH secretion|Type II diabetes mellitus|Cushing syndrome CACNA1S 20.01066797 33.29324424 6.728091692 0.202085794 -2.306960188 0.010053388 0.610531935 0.294611052 0.058540442 779 calcium voltage-gated channel subunit alpha1 S "GO:0005245,GO:0005515,GO:0005516,GO:0005737,GO:0005886,GO:0005891,GO:0006816,GO:0006936,GO:0008331,GO:0030315,GO:0031674,GO:0034765,GO:0046872,GO:0061337,GO:0070509,GO:0070588,GO:0071313,GO:1990454" voltage-gated calcium channel activity|protein binding|calmodulin binding|cytoplasm|plasma membrane|voltage-gated calcium channel complex|calcium ion transport|muscle contraction|high voltage-gated calcium channel activity|T-tubule|I band|regulation of ion transmembrane transport|metal ion binding|cardiac conduction|calcium ion import|calcium ion transmembrane transport|cellular response to caffeine|L-type voltage-gated calcium channel complex "hsa04010,hsa04020,hsa04022,hsa04024,hsa04260,hsa04261,hsa04270,hsa04723,hsa04725,hsa04726,hsa04727,hsa04911,hsa04912,hsa04921,hsa04924,hsa04925,hsa04927,hsa04929,hsa04934,hsa04935,hsa05010,hsa05020,hsa05022,hsa05410,hsa05412,hsa05414" "MAPK signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Retrograde endocannabinoid signaling|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Insulin secretion|GnRH signaling pathway|Oxytocin signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|GnRH secretion|Cushing syndrome|Growth hormone synthesis, secretion and action|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy" CACNA2D1 383.6572848 407.842242 359.4723275 0.88140043 -0.182130494 0.537509288 1 1.499951132 1.29993473 781 calcium voltage-gated channel auxiliary subunit alpha2delta 1 "GO:0005245,GO:0005886,GO:0005891,GO:0006816,GO:0016529,GO:0046872,GO:0051924,GO:0060307,GO:0060402,GO:0061337,GO:0061577,GO:0070062,GO:0086002,GO:0086007,GO:0086048,GO:0086057,GO:0086091,GO:0098703,GO:0098903,GO:1901843,GO:1902514,GO:1904646,GO:1990454" voltage-gated calcium channel activity|plasma membrane|voltage-gated calcium channel complex|calcium ion transport|sarcoplasmic reticulum|metal ion binding|regulation of calcium ion transport|regulation of ventricular cardiac muscle cell membrane repolarization|calcium ion transport into cytosol|cardiac conduction|calcium ion transmembrane transport via high voltage-gated calcium channel|extracellular exosome|cardiac muscle cell action potential involved in contraction|voltage-gated calcium channel activity involved in cardiac muscle cell action potential|membrane depolarization during bundle of His cell action potential|voltage-gated calcium channel activity involved in bundle of His cell action potential|regulation of heart rate by cardiac conduction|calcium ion import across plasma membrane|regulation of membrane repolarization during action potential|positive regulation of high voltage-gated calcium channel activity|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|cellular response to amyloid-beta|L-type voltage-gated calcium channel complex "hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy CACNA2D2 10.32991132 6.242483296 14.41733934 2.309551929 1.207612985 0.304444422 1 0.058110912 0.131964344 9254 calcium voltage-gated channel auxiliary subunit alpha2delta 2 "GO:0005245,GO:0005886,GO:0005891,GO:0034765,GO:0046872,GO:0050796,GO:0061337,GO:0070588" voltage-gated calcium channel activity|plasma membrane|voltage-gated calcium channel complex|regulation of ion transmembrane transport|metal ion binding|regulation of insulin secretion|cardiac conduction|calcium ion transmembrane transport "hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy CACNA2D3 55.80115128 64.50566072 47.09664184 0.730116416 -0.453801576 0.439642737 1 0.908563884 0.652257019 55799 calcium voltage-gated channel auxiliary subunit alpha2delta 3 "GO:0005245,GO:0005886,GO:0005891,GO:0034765,GO:0046872,GO:0061337,GO:0070588" voltage-gated calcium channel activity|plasma membrane|voltage-gated calcium channel complex|regulation of ion transmembrane transport|metal ion binding|cardiac conduction|calcium ion transmembrane transport "hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy CACNA2D4 537.2478946 591.9954992 482.5002899 0.81504047 -0.295056398 0.273095317 1 3.347500715 2.682693338 93589 calcium voltage-gated channel auxiliary subunit alpha2delta 4 "GO:0005245,GO:0005886,GO:0005891,GO:0034765,GO:0046872,GO:0050908,GO:0061337,GO:0070588" voltage-gated calcium channel activity|plasma membrane|voltage-gated calcium channel complex|regulation of ion transmembrane transport|metal ion binding|detection of light stimulus involved in visual perception|cardiac conduction|calcium ion transmembrane transport "hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy CACNB1 229.253974 252.8205735 205.6873746 0.813570556 -0.297660627 0.391714773 1 2.884260227 2.307282874 782 calcium voltage-gated channel auxiliary subunit beta 1 "GO:0005245,GO:0005515,GO:0005886,GO:0005891,GO:0007268,GO:0007528,GO:0008331,GO:0042383,GO:0045202,GO:0061337,GO:0070588,GO:1901385,GO:1902514,GO:1904646" voltage-gated calcium channel activity|protein binding|plasma membrane|voltage-gated calcium channel complex|chemical synaptic transmission|neuromuscular junction development|high voltage-gated calcium channel activity|sarcolemma|synapse|cardiac conduction|calcium ion transmembrane transport|regulation of voltage-gated calcium channel activity|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|cellular response to amyloid-beta "hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy CACNB3 1032.05267 965.5040831 1098.601258 1.137852524 0.186313583 0.448395877 1 8.900877249 9.958409191 784 calcium voltage-gated channel auxiliary subunit beta 3 "GO:0005245,GO:0005246,GO:0005515,GO:0005829,GO:0005886,GO:0005891,GO:0006816,GO:0007268,GO:0007528,GO:0008331,GO:0016020,GO:0016324,GO:0019901,GO:0045202,GO:0050852,GO:0050966,GO:0051899,GO:0060402,GO:0061337,GO:0061577,GO:0072659,GO:0090314,GO:0090650,GO:0098903,GO:1901385,GO:1901386,GO:1901843,GO:1902630,GO:1905788,GO:1990454,GO:2000463" voltage-gated calcium channel activity|calcium channel regulator activity|protein binding|cytosol|plasma membrane|voltage-gated calcium channel complex|calcium ion transport|chemical synaptic transmission|neuromuscular junction development|high voltage-gated calcium channel activity|membrane|apical plasma membrane|protein kinase binding|synapse|T cell receptor signaling pathway|detection of mechanical stimulus involved in sensory perception of pain|membrane depolarization|calcium ion transport into cytosol|cardiac conduction|calcium ion transmembrane transport via high voltage-gated calcium channel|protein localization to plasma membrane|positive regulation of protein targeting to membrane|cellular response to oxygen-glucose deprivation|regulation of membrane repolarization during action potential|regulation of voltage-gated calcium channel activity|negative regulation of voltage-gated calcium channel activity|positive regulation of high voltage-gated calcium channel activity|regulation of membrane hyperpolarization|negative regulation of detection of mechanical stimulus involved in sensory perception of touch|L-type voltage-gated calcium channel complex|positive regulation of excitatory postsynaptic potential "hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy CACNB4 76.02505532 65.54607461 86.50403604 1.31974396 0.400258063 0.44573693 1 0.173679238 0.225376571 785 calcium voltage-gated channel auxiliary subunit beta 4 "GO:0005245,GO:0005515,GO:0005829,GO:0005886,GO:0005891,GO:0007268,GO:0007528,GO:0008331,GO:0009898,GO:0045202,GO:0051899,GO:0061337,GO:0070588,GO:1901385" voltage-gated calcium channel activity|protein binding|cytosol|plasma membrane|voltage-gated calcium channel complex|chemical synaptic transmission|neuromuscular junction development|high voltage-gated calcium channel activity|cytoplasmic side of plasma membrane|synapse|membrane depolarization|cardiac conduction|calcium ion transmembrane transport|regulation of voltage-gated calcium channel activity "hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy CACNG7 17.41466368 15.60620824 19.22311912 1.231761029 0.300722389 0.792076496 1 0.30242362 0.366280119 59284 calcium voltage-gated channel auxiliary subunit gamma 7 "GO:0005245,GO:0005246,GO:0005515,GO:0005769,GO:0005886,GO:0005891,GO:0006816,GO:0016247,GO:0019226,GO:0032281,GO:0043025,GO:0043488,GO:0044300,GO:0051968,GO:0061337,GO:0070588,GO:0098839,GO:0098943,GO:0098970,GO:0098978,GO:0099061,GO:0099590,GO:1903861,GO:1990454,GO:2000311" "voltage-gated calcium channel activity|calcium channel regulator activity|protein binding|early endosome|plasma membrane|voltage-gated calcium channel complex|calcium ion transport|channel regulator activity|transmission of nerve impulse|AMPA glutamate receptor complex|neuronal cell body|regulation of mRNA stability|cerebellar mossy fiber|positive regulation of synaptic transmission, glutamatergic|cardiac conduction|calcium ion transmembrane transport|postsynaptic density membrane|neurotransmitter receptor transport, postsynaptic endosome to lysosome|postsynaptic neurotransmitter receptor diffusion trapping|glutamatergic synapse|integral component of postsynaptic density membrane|neurotransmitter receptor internalization|positive regulation of dendrite extension|L-type voltage-gated calcium channel complex|regulation of AMPA receptor activity" "hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy CACNG8 17.73169539 23.9295193 11.53387147 0.481993446 -1.052914565 0.24504821 1 0.144302199 0.068388844 59283 calcium voltage-gated channel auxiliary subunit gamma 8 "GO:0005245,GO:0005246,GO:0005886,GO:0005891,GO:0006816,GO:0014069,GO:0016247,GO:0019226,GO:0030666,GO:0032281,GO:0051968,GO:0061337,GO:0070588,GO:0098839,GO:0098943,GO:0098970,GO:0099590,GO:1990454,GO:2000311" "voltage-gated calcium channel activity|calcium channel regulator activity|plasma membrane|voltage-gated calcium channel complex|calcium ion transport|postsynaptic density|channel regulator activity|transmission of nerve impulse|endocytic vesicle membrane|AMPA glutamate receptor complex|positive regulation of synaptic transmission, glutamatergic|cardiac conduction|calcium ion transmembrane transport|postsynaptic density membrane|neurotransmitter receptor transport, postsynaptic endosome to lysosome|postsynaptic neurotransmitter receptor diffusion trapping|neurotransmitter receptor internalization|L-type voltage-gated calcium channel complex|regulation of AMPA receptor activity" "hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy CACTIN 463.0312947 510.8432164 415.219373 0.812811758 -0.299006822 0.283457603 1 6.337230025 5.064780488 58509 "cactin, spliceosome C complex subunit" "GO:0000398,GO:0001933,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0005829,GO:0007275,GO:0010468,GO:0016607,GO:0031665,GO:0032088,GO:0032688,GO:0032717,GO:0032720,GO:0034122,GO:0043124,GO:0045087,GO:0045292,GO:0045824,GO:0060339,GO:0071013,GO:0071222,GO:0071347,GO:0071356" "mRNA splicing, via spliceosome|negative regulation of protein phosphorylation|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|cytosol|multicellular organism development|regulation of gene expression|nuclear speck|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|negative regulation of interferon-beta production|negative regulation of interleukin-8 production|negative regulation of tumor necrosis factor production|negative regulation of toll-like receptor signaling pathway|negative regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|mRNA cis splicing, via spliceosome|negative regulation of innate immune response|negative regulation of type I interferon-mediated signaling pathway|catalytic step 2 spliceosome|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to tumor necrosis factor" CACUL1 1161.674132 1100.757888 1222.590376 1.11068055 0.151443933 0.53416643 1 5.323554632 5.813826411 143384 CDK2 associated cullin domain 1 "GO:0000082,GO:0005515,GO:0006511,GO:0008284,GO:0019901,GO:0031625,GO:0045860" G1/S transition of mitotic cell cycle|protein binding|ubiquitin-dependent protein catabolic process|positive regulation of cell population proliferation|protein kinase binding|ubiquitin protein ligase binding|positive regulation of protein kinase activity CACYBP 2770.12984 2588.54974 2951.709941 1.140294851 0.189406917 0.423543754 1 60.45783023 67.78613913 27101 calcyclin binding protein "GO:0005515,GO:0005634,GO:0005641,GO:0005654,GO:0005829,GO:0007507,GO:0007568,GO:0015631,GO:0019005,GO:0019904,GO:0030877,GO:0031625,GO:0042803,GO:0043005,GO:0044297,GO:0044548,GO:0045740,GO:0055007,GO:0060416,GO:0060548,GO:0070062,GO:0071277,GO:1990830" protein binding|nucleus|nuclear envelope lumen|nucleoplasm|cytosol|heart development|aging|tubulin binding|SCF ubiquitin ligase complex|protein domain specific binding|beta-catenin destruction complex|ubiquitin protein ligase binding|protein homodimerization activity|neuron projection|cell body|S100 protein binding|positive regulation of DNA replication|cardiac muscle cell differentiation|response to growth hormone|negative regulation of cell death|extracellular exosome|cellular response to calcium ion|cellular response to leukemia inhibitory factor hsa04310 Wnt signaling pathway CAD 1742.747129 1960.139755 1525.354502 0.778186605 -0.361811947 0.127313224 1 14.15357274 10.82981433 790 "carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase" "GO:0001889,GO:0004070,GO:0004088,GO:0004151,GO:0004672,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006207,GO:0006228,GO:0006541,GO:0006807,GO:0007507,GO:0007565,GO:0007595,GO:0008270,GO:0014075,GO:0016020,GO:0016363,GO:0017144,GO:0018107,GO:0019240,GO:0019899,GO:0031000,GO:0031100,GO:0032868,GO:0032991,GO:0033574,GO:0035690,GO:0042594,GO:0042802,GO:0042995,GO:0043025,GO:0043195,GO:0044205,GO:0046134,GO:0046777,GO:0051414,GO:0070062,GO:0070335,GO:0071364" liver development|aspartate carbamoyltransferase activity|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|protein kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|'de novo' pyrimidine nucleobase biosynthetic process|UTP biosynthetic process|glutamine metabolic process|nitrogen compound metabolic process|heart development|female pregnancy|lactation|zinc ion binding|response to amine|membrane|nuclear matrix|drug metabolic process|peptidyl-threonine phosphorylation|citrulline biosynthetic process|enzyme binding|response to caffeine|animal organ regeneration|response to insulin|protein-containing complex|response to testosterone|cellular response to drug|response to starvation|identical protein binding|cell projection|neuronal cell body|terminal bouton|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process|protein autophosphorylation|response to cortisol|extracellular exosome|aspartate binding|cellular response to epidermal growth factor stimulus "hsa00240,hsa00250" "Pyrimidine metabolism|Alanine, aspartate and glutamate metabolism" CADM1 2.962725795 2.080827765 3.844623824 1.847641543 0.88568489 0.829811711 1 0.012480327 0.022673307 23705 cell adhesion molecule 1 "GO:0001819,GO:0001913,GO:0005102,GO:0005515,GO:0005886,GO:0005911,GO:0006915,GO:0007156,GO:0007157,GO:0007275,GO:0007283,GO:0008037,GO:0016021,GO:0016032,GO:0016323,GO:0030154,GO:0030165,GO:0034332,GO:0042271,GO:0042803,GO:0045202,GO:0045954,GO:0050798,GO:0051606" positive regulation of cytokine production|T cell mediated cytotoxicity|signaling receptor binding|protein binding|plasma membrane|cell-cell junction|apoptotic process|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|multicellular organism development|spermatogenesis|cell recognition|integral component of membrane|viral process|basolateral plasma membrane|cell differentiation|PDZ domain binding|adherens junction organization|susceptibility to natural killer cell mediated cytotoxicity|protein homodimerization activity|synapse|positive regulation of natural killer cell mediated cytotoxicity|activated T cell proliferation|detection of stimulus hsa04514 Cell adhesion molecules CADM4 152.6942349 122.7688382 182.6196316 1.487508022 0.572897449 0.15567427 1 3.002725597 4.391836273 199731 cell adhesion molecule 4 "GO:0001932,GO:0001933,GO:0007155,GO:0010801,GO:0016021,GO:0019903,GO:0030948,GO:0030971,GO:0031252,GO:0035020,GO:0042127,GO:0043183,GO:0043184,GO:0044291,GO:0050732,GO:0061041,GO:1900747,GO:2000145" regulation of protein phosphorylation|negative regulation of protein phosphorylation|cell adhesion|negative regulation of peptidyl-threonine phosphorylation|integral component of membrane|protein phosphatase binding|negative regulation of vascular endothelial growth factor receptor signaling pathway|receptor tyrosine kinase binding|cell leading edge|regulation of Rac protein signal transduction|regulation of cell population proliferation|vascular endothelial growth factor receptor 1 binding|vascular endothelial growth factor receptor 2 binding|cell-cell contact zone|negative regulation of peptidyl-tyrosine phosphorylation|regulation of wound healing|negative regulation of vascular endothelial growth factor signaling pathway|regulation of cell motility CADPS2 288.3745118 328.7707869 247.9782366 0.754258731 -0.406868603 0.203483803 1 3.182639696 2.360364097 93664 calcium dependent secretion activator 2 "GO:0005654,GO:0006887,GO:0008289,GO:0015031,GO:0016079,GO:0030659,GO:0043231,GO:0045921,GO:0046872,GO:0098793,GO:0098978,GO:1990504" nucleoplasm|exocytosis|lipid binding|protein transport|synaptic vesicle exocytosis|cytoplasmic vesicle membrane|intracellular membrane-bounded organelle|positive regulation of exocytosis|metal ion binding|presynapse|glutamatergic synapse|dense core granule exocytosis CALB1 3.923881751 2.080827765 5.766935736 2.771462315 1.470647391 0.503574097 1 0.043841277 0.119471233 793 calbindin 1 "GO:0005499,GO:0005509,GO:0005515,GO:0005634,GO:0005829,GO:0007614,GO:0007616,GO:0007626,GO:0008270,GO:0010842,GO:0030424,GO:0030425,GO:0032420,GO:0032437,GO:0035502,GO:0043005,GO:0043025,GO:0043195,GO:0043197,GO:0044267,GO:0044305,GO:0045202,GO:0051480,GO:0070062,GO:0071310,GO:0072205,GO:0072221,GO:0072286,GO:0090102,GO:0098686,GO:0098978,GO:0098982,GO:0099509,GO:0099523,GO:0099524,GO:0099534,GO:0099566,GO:0099567,GO:1900271" vitamin D binding|calcium ion binding|protein binding|nucleus|cytosol|short-term memory|long-term memory|locomotory behavior|zinc ion binding|retina layer formation|axon|dendrite|stereocilium|cuticular plate|metanephric part of ureteric bud development|neuron projection|neuronal cell body|terminal bouton|dendritic spine|cellular protein metabolic process|calyx of Held|synapse|regulation of cytosolic calcium ion concentration|extracellular exosome|cellular response to organic substance|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric connecting tubule development|cochlea development|hippocampal mossy fiber to CA3 synapse|glutamatergic synapse|GABA-ergic synapse|regulation of presynaptic cytosolic calcium ion concentration|presynaptic cytosol|postsynaptic cytosol|calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration|regulation of postsynaptic cytosolic calcium ion concentration|calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration|regulation of long-term synaptic potentiation hsa04961 Endocrine and other factor-regulated calcium reabsorption CALB2 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.114563226 0.034688289 794 calbindin 2 "GO:0005509,GO:0005634,GO:0005829,GO:0005921,GO:0030425,GO:0032420,GO:0032437,GO:0043005,GO:0043195,GO:0045202,GO:0051480,GO:0097060,GO:0098688,GO:0099509,GO:0099534,GO:1900271" calcium ion binding|nucleus|cytosol|gap junction|dendrite|stereocilium|cuticular plate|neuron projection|terminal bouton|synapse|regulation of cytosolic calcium ion concentration|synaptic membrane|parallel fiber to Purkinje cell synapse|regulation of presynaptic cytosolic calcium ion concentration|calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration|regulation of long-term synaptic potentiation CALCOCO1 1417.66245 1298.436526 1536.888374 1.183645364 0.243236895 0.309833345 1 11.90638676 13.85711323 57658 calcium binding and coiled-coil domain 1 "GO:0000976,GO:0000978,GO:0003682,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005829,GO:0007165,GO:0008013,GO:0008022,GO:0010628,GO:0016055,GO:0030374,GO:0030518,GO:0043231,GO:0043565,GO:0045893,GO:0045944,GO:0046872,GO:0070016" "transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|chromatin binding|transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|cytosol|signal transduction|beta-catenin binding|protein C-terminus binding|positive regulation of gene expression|Wnt signaling pathway|nuclear receptor coactivator activity|intracellular steroid hormone receptor signaling pathway|intracellular membrane-bounded organelle|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|armadillo repeat domain binding" CALCOCO2 2362.214715 2351.335375 2373.094055 1.009253755 0.013288954 0.957108768 1 33.28552981 33.03140344 10241 calcium binding and coiled-coil domain 2 "GO:0000421,GO:0005515,GO:0005634,GO:0005737,GO:0005776,GO:0005829,GO:0005856,GO:0016020,GO:0016032,GO:0016605,GO:0031410,GO:0034341,GO:0042803,GO:0043231,GO:0046872,GO:0048471,GO:0098792,GO:1901098" autophagosome membrane|protein binding|nucleus|cytoplasm|autophagosome|cytosol|cytoskeleton|membrane|viral process|PML body|cytoplasmic vesicle|response to interferon-gamma|protein homodimerization activity|intracellular membrane-bounded organelle|metal ion binding|perinuclear region of cytoplasm|xenophagy|positive regulation of autophagosome maturation "hsa04137,hsa05131,hsa05164" Mitophagy - animal|Shigellosis|Influenza A CALCRL 123.8941548 136.2942186 111.4940909 0.818039767 -0.289757116 0.511978536 1 1.165855418 0.937756947 10203 calcitonin receptor like receptor "GO:0001525,GO:0001605,GO:0001635,GO:0004930,GO:0004948,GO:0005515,GO:0005737,GO:0005764,GO:0005768,GO:0005783,GO:0005886,GO:0005887,GO:0006816,GO:0007166,GO:0007186,GO:0007187,GO:0007188,GO:0007189,GO:0007507,GO:0008528,GO:0015031,GO:0031623,GO:0045986,GO:0048661,GO:0050728,GO:0071329,GO:1903143,GO:1990406,GO:1990408,GO:1990409,GO:1990410" "angiogenesis|adrenomedullin receptor activity|calcitonin gene-related peptide receptor activity|G protein-coupled receptor activity|calcitonin receptor activity|protein binding|cytoplasm|lysosome|endosome|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|calcium ion transport|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|heart development|G protein-coupled peptide receptor activity|protein transport|receptor internalization|negative regulation of smooth muscle contraction|positive regulation of smooth muscle cell proliferation|negative regulation of inflammatory response|cellular response to sucrose stimulus|adrenomedullin receptor complex|CGRP receptor complex|calcitonin gene-related peptide receptor signaling pathway|adrenomedullin binding|adrenomedullin receptor signaling pathway" "hsa04080,hsa04270" Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction CALD1 2082.164743 1837.370917 2326.958569 1.266460979 0.340802626 0.149674868 1 20.63057203 25.69060086 800 caldesmon 1 "GO:0003779,GO:0005515,GO:0005516,GO:0005523,GO:0005829,GO:0005856,GO:0005886,GO:0006936,GO:0015629,GO:0017022,GO:0030016,GO:0030478,GO:0045296" actin binding|protein binding|calmodulin binding|tropomyosin binding|cytosol|cytoskeleton|plasma membrane|muscle contraction|actin cytoskeleton|myosin binding|myofibril|actin cap|cadherin binding hsa04270 Vascular smooth muscle contraction CALHM2 847.7642063 833.37152 862.1568925 1.034540864 0.048990633 0.849006965 1 16.98835231 17.28104844 51063 calcium homeostasis modulator family member 2 "GO:0005261,GO:0005887,GO:0043065,GO:0098655" cation channel activity|integral component of plasma membrane|positive regulation of apoptotic process|cation transmembrane transport CALHM3 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.100832282 0.122122935 119395 calcium homeostasis modulator 3 "GO:0005244,GO:0005261,GO:0005515,GO:0005887,GO:0015867,GO:0016323,GO:0050896,GO:0050909,GO:0051291,GO:0098655" voltage-gated ion channel activity|cation channel activity|protein binding|integral component of plasma membrane|ATP transport|basolateral plasma membrane|response to stimulus|sensory perception of taste|protein heterooligomerization|cation transmembrane transport CALHM4 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.021233261 0.028931227 221301 calcium homeostasis modulator family member 4 "GO:0005261,GO:0005887,GO:0098655" cation channel activity|integral component of plasma membrane|cation transmembrane transport CALHM5 159.2040601 167.5066351 150.9014851 0.900868703 -0.150611239 0.715631031 1 0.913407709 0.809090964 254228 calcium homeostasis modulator family member 5 "GO:0005261,GO:0005887,GO:0098655" cation channel activity|integral component of plasma membrane|cation transmembrane transport CALHM6 3.443303773 2.080827765 4.80577978 2.309551929 1.207612985 0.648665767 1 0.096565177 0.219290315 441168 calcium homeostasis modulator family member 6 "GO:0005261,GO:0005515,GO:0005887,GO:0098655" cation channel activity|protein binding|integral component of plasma membrane|cation transmembrane transport CALM1 8295.942614 7739.638873 8852.246355 1.143754444 0.193777349 0.433499657 1 78.21441049 87.96111976 801 calmodulin 1 "GO:0000086,GO:0000165,GO:0000922,GO:0001975,GO:0002027,GO:0002576,GO:0005509,GO:0005513,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005876,GO:0005886,GO:0005980,GO:0006936,GO:0007186,GO:0007190,GO:0007223,GO:0008076,GO:0008179,GO:0010800,GO:0010801,GO:0010856,GO:0010880,GO:0010881,GO:0016032,GO:0019855,GO:0019901,GO:0019904,GO:0021762,GO:0022400,GO:0030017,GO:0030234,GO:0030235,GO:0030426,GO:0030672,GO:0031432,GO:0031800,GO:0031954,GO:0031966,GO:0031982,GO:0031997,GO:0032465,GO:0032516,GO:0032991,GO:0034704,GO:0035307,GO:0038095,GO:0043209,GO:0043388,GO:0043539,GO:0043548,GO:0043647,GO:0044325,GO:0048306,GO:0050998,GO:0050999,GO:0051000,GO:0051343,GO:0051412,GO:0051592,GO:0055117,GO:0060314,GO:0060315,GO:0060316,GO:0071902,GO:0072542,GO:0090151,GO:0097718,GO:0098901,GO:1900242,GO:1901842,GO:1901844,GO:1902494,GO:2000300" "G2/M transition of mitotic cell cycle|MAPK cascade|spindle pole|response to amphetamine|regulation of heart rate|platelet degranulation|calcium ion binding|detection of calcium ion|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|spindle microtubule|plasma membrane|glycogen catabolic process|muscle contraction|G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|Wnt signaling pathway, calcium modulating pathway|voltage-gated potassium channel complex|adenylate cyclase binding|positive regulation of peptidyl-threonine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|adenylate cyclase activator activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|viral process|calcium channel inhibitor activity|protein kinase binding|protein domain specific binding|substantia nigra development|regulation of rhodopsin mediated signaling pathway|sarcomere|enzyme regulator activity|nitric-oxide synthase regulator activity|growth cone|synaptic vesicle membrane|titin binding|type 3 metabotropic glutamate receptor binding|positive regulation of protein autophosphorylation|mitochondrial membrane|vesicle|N-terminal myristoylation domain binding|regulation of cytokinesis|positive regulation of phosphoprotein phosphatase activity|protein-containing complex|calcium channel complex|positive regulation of protein dephosphorylation|Fc-epsilon receptor signaling pathway|myelin sheath|positive regulation of DNA binding|protein serine/threonine kinase activator activity|phosphatidylinositol 3-kinase binding|inositol phosphate metabolic process|ion channel binding|calcium-dependent protein binding|nitric-oxide synthase binding|regulation of nitric-oxide synthase activity|positive regulation of nitric-oxide synthase activity|positive regulation of cyclic-nucleotide phosphodiesterase activity|response to corticosterone|response to calcium ion|regulation of cardiac muscle contraction|regulation of ryanodine-sensitive calcium-release channel activity|negative regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of protein serine/threonine kinase activity|protein phosphatase activator activity|establishment of protein localization to mitochondrial membrane|disordered domain specific binding|regulation of cardiac muscle cell action potential|regulation of synaptic vesicle endocytosis|negative regulation of high voltage-gated calcium channel activity|regulation of cell communication by electrical coupling involved in cardiac conduction|catalytic complex|regulation of synaptic vesicle exocytosis" "hsa04014,hsa04015,hsa04020,hsa04022,hsa04024,hsa04070,hsa04114,hsa04218,hsa04261,hsa04270,hsa04371,hsa04625,hsa04713,hsa04720,hsa04722,hsa04728,hsa04740,hsa04744,hsa04750,hsa04910,hsa04912,hsa04915,hsa04916,hsa04921,hsa04922,hsa04924,hsa04925,hsa04970,hsa04971,hsa05010,hsa05012,hsa05022,hsa05031,hsa05034,hsa05133,hsa05152,hsa05163,hsa05167,hsa05170,hsa05200,hsa05214,hsa05418" Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Dopaminergic synapse|Olfactory transduction|Phototransduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Salivary secretion|Gastric acid secretion|Alzheimer disease|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Alcoholism|Pertussis|Tuberculosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Glioma|Fluid shear stress and atherosclerosis CALM2 11325.71032 10016.06445 12635.3562 1.261509075 0.335150585 0.187847468 1 397.1314642 492.6016415 805 calmodulin 2 "GO:0000922,GO:0002027,GO:0005509,GO:0005513,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005876,GO:0005886,GO:0007186,GO:0008179,GO:0010800,GO:0010801,GO:0010856,GO:0010880,GO:0010881,GO:0019855,GO:0019901,GO:0019904,GO:0021762,GO:0030017,GO:0030234,GO:0031432,GO:0031954,GO:0031982,GO:0031997,GO:0032465,GO:0032516,GO:0032991,GO:0034704,GO:0035307,GO:0043539,GO:0044325,GO:0051343,GO:0051592,GO:0055117,GO:0060314,GO:0060315,GO:0060316,GO:0071902,GO:0072542,GO:0097718,GO:1901844,GO:1902494" spindle pole|regulation of heart rate|calcium ion binding|detection of calcium ion|protein binding|nucleus|cytoplasm|centrosome|spindle microtubule|plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase binding|positive regulation of peptidyl-threonine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|adenylate cyclase activator activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|calcium channel inhibitor activity|protein kinase binding|protein domain specific binding|substantia nigra development|sarcomere|enzyme regulator activity|titin binding|positive regulation of protein autophosphorylation|vesicle|N-terminal myristoylation domain binding|regulation of cytokinesis|positive regulation of phosphoprotein phosphatase activity|protein-containing complex|calcium channel complex|positive regulation of protein dephosphorylation|protein serine/threonine kinase activator activity|ion channel binding|positive regulation of cyclic-nucleotide phosphodiesterase activity|response to calcium ion|regulation of cardiac muscle contraction|regulation of ryanodine-sensitive calcium-release channel activity|negative regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of protein serine/threonine kinase activity|protein phosphatase activator activity|disordered domain specific binding|regulation of cell communication by electrical coupling involved in cardiac conduction|catalytic complex "hsa04014,hsa04015,hsa04020,hsa04022,hsa04024,hsa04070,hsa04114,hsa04218,hsa04261,hsa04270,hsa04371,hsa04625,hsa04713,hsa04720,hsa04722,hsa04728,hsa04740,hsa04744,hsa04750,hsa04910,hsa04912,hsa04915,hsa04916,hsa04921,hsa04922,hsa04924,hsa04925,hsa04970,hsa04971,hsa05010,hsa05012,hsa05022,hsa05031,hsa05034,hsa05133,hsa05152,hsa05163,hsa05167,hsa05170,hsa05200,hsa05214,hsa05418" Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Dopaminergic synapse|Olfactory transduction|Phototransduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Salivary secretion|Gastric acid secretion|Alzheimer disease|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Alcoholism|Pertussis|Tuberculosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Glioma|Fluid shear stress and atherosclerosis CALM3 5235.035372 4822.318346 5647.752397 1.171169548 0.227949947 0.343359279 1 104.1093313 119.8893505 808 calmodulin 3 "GO:0000086,GO:0000922,GO:0001975,GO:0002027,GO:0005509,GO:0005513,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005876,GO:0005886,GO:0007186,GO:0007190,GO:0008076,GO:0008179,GO:0010800,GO:0010801,GO:0010856,GO:0010880,GO:0010881,GO:0019901,GO:0019904,GO:0021762,GO:0030017,GO:0030234,GO:0030235,GO:0030426,GO:0030672,GO:0031432,GO:0031800,GO:0031954,GO:0031966,GO:0031982,GO:0031997,GO:0032465,GO:0032516,GO:0032991,GO:0034704,GO:0035307,GO:0043209,GO:0043388,GO:0043539,GO:0043548,GO:0044325,GO:0048306,GO:0050998,GO:0051000,GO:0051343,GO:0051412,GO:0051592,GO:0055117,GO:0060315,GO:0060316,GO:0071902,GO:0072542,GO:0090151,GO:0097718,GO:0098901,GO:1900242,GO:1901842,GO:1901844,GO:1902494,GO:2000300" G2/M transition of mitotic cell cycle|spindle pole|response to amphetamine|regulation of heart rate|calcium ion binding|detection of calcium ion|protein binding|nucleus|cytoplasm|centrosome|spindle microtubule|plasma membrane|G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|voltage-gated potassium channel complex|adenylate cyclase binding|positive regulation of peptidyl-threonine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|adenylate cyclase activator activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|protein kinase binding|protein domain specific binding|substantia nigra development|sarcomere|enzyme regulator activity|nitric-oxide synthase regulator activity|growth cone|synaptic vesicle membrane|titin binding|type 3 metabotropic glutamate receptor binding|positive regulation of protein autophosphorylation|mitochondrial membrane|vesicle|N-terminal myristoylation domain binding|regulation of cytokinesis|positive regulation of phosphoprotein phosphatase activity|protein-containing complex|calcium channel complex|positive regulation of protein dephosphorylation|myelin sheath|positive regulation of DNA binding|protein serine/threonine kinase activator activity|phosphatidylinositol 3-kinase binding|ion channel binding|calcium-dependent protein binding|nitric-oxide synthase binding|positive regulation of nitric-oxide synthase activity|positive regulation of cyclic-nucleotide phosphodiesterase activity|response to corticosterone|response to calcium ion|regulation of cardiac muscle contraction|negative regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of protein serine/threonine kinase activity|protein phosphatase activator activity|establishment of protein localization to mitochondrial membrane|disordered domain specific binding|regulation of cardiac muscle cell action potential|regulation of synaptic vesicle endocytosis|negative regulation of high voltage-gated calcium channel activity|regulation of cell communication by electrical coupling involved in cardiac conduction|catalytic complex|regulation of synaptic vesicle exocytosis "hsa04014,hsa04015,hsa04020,hsa04022,hsa04024,hsa04070,hsa04114,hsa04218,hsa04261,hsa04270,hsa04371,hsa04625,hsa04713,hsa04720,hsa04722,hsa04728,hsa04740,hsa04744,hsa04750,hsa04910,hsa04912,hsa04915,hsa04916,hsa04921,hsa04922,hsa04924,hsa04925,hsa04970,hsa04971,hsa05010,hsa05012,hsa05022,hsa05031,hsa05034,hsa05133,hsa05152,hsa05163,hsa05167,hsa05170,hsa05200,hsa05214,hsa05418" Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Dopaminergic synapse|Olfactory transduction|Phototransduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Salivary secretion|Gastric acid secretion|Alzheimer disease|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Alcoholism|Pertussis|Tuberculosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Glioma|Fluid shear stress and atherosclerosis CALML4 152.6395147 159.183324 146.0957053 0.917782727 -0.123775439 0.771964111 1 2.20257232 1.987656054 91860 calmodulin like 4 "GO:0005509,GO:0030234,GO:0050790" calcium ion binding|enzyme regulator activity|regulation of catalytic activity "hsa04014,hsa04015,hsa04020,hsa04022,hsa04024,hsa04070,hsa04114,hsa04218,hsa04261,hsa04270,hsa04371,hsa04625,hsa04713,hsa04720,hsa04722,hsa04728,hsa04740,hsa04744,hsa04750,hsa04910,hsa04912,hsa04915,hsa04916,hsa04921,hsa04922,hsa04924,hsa04925,hsa04970,hsa04971,hsa05010,hsa05012,hsa05022,hsa05031,hsa05034,hsa05133,hsa05152,hsa05163,hsa05167,hsa05170,hsa05200,hsa05214,hsa05418" Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Dopaminergic synapse|Olfactory transduction|Phototransduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Salivary secretion|Gastric acid secretion|Alzheimer disease|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Alcoholism|Pertussis|Tuberculosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Glioma|Fluid shear stress and atherosclerosis CALML6 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.074198187 0.089865073 163688 calmodulin like 6 "GO:0005509,GO:0005515,GO:0005634,GO:0005737,GO:0030234,GO:0050790" calcium ion binding|protein binding|nucleus|cytoplasm|enzyme regulator activity|regulation of catalytic activity "hsa04014,hsa04015,hsa04020,hsa04022,hsa04024,hsa04070,hsa04114,hsa04218,hsa04261,hsa04270,hsa04371,hsa04625,hsa04713,hsa04720,hsa04722,hsa04728,hsa04740,hsa04744,hsa04750,hsa04910,hsa04912,hsa04915,hsa04916,hsa04921,hsa04922,hsa04924,hsa04925,hsa04970,hsa04971,hsa05010,hsa05012,hsa05022,hsa05031,hsa05034,hsa05133,hsa05152,hsa05163,hsa05167,hsa05170,hsa05200,hsa05214,hsa05418" Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Dopaminergic synapse|Olfactory transduction|Phototransduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Salivary secretion|Gastric acid secretion|Alzheimer disease|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Alcoholism|Pertussis|Tuberculosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Glioma|Fluid shear stress and atherosclerosis CALR 17117.46907 16294.96223 17939.97592 1.100952286 0.138751946 0.603532766 1 457.4603816 495.2142852 811 calreticulin "GO:0000122,GO:0001669,GO:0001849,GO:0002474,GO:0002479,GO:0002502,GO:0003677,GO:0003723,GO:0003729,GO:0005178,GO:0005506,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005635,GO:0005737,GO:0005783,GO:0005788,GO:0005789,GO:0005790,GO:0005794,GO:0005829,GO:0005844,GO:0005925,GO:0006355,GO:0006457,GO:0006611,GO:0006874,GO:0006898,GO:0007283,GO:0008270,GO:0008284,GO:0009897,GO:0009986,GO:0010595,GO:0010628,GO:0016020,GO:0017148,GO:0022417,GO:0030246,GO:0030670,GO:0030866,GO:0030968,GO:0031625,GO:0032355,GO:0033018,GO:0033116,GO:0033144,GO:0033574,GO:0034504,GO:0034975,GO:0036500,GO:0040020,GO:0042277,GO:0042493,GO:0042562,GO:0042824,GO:0042921,GO:0042981,GO:0044183,GO:0044322,GO:0045665,GO:0045787,GO:0045892,GO:0048387,GO:0048471,GO:0050681,GO:0050766,GO:0050821,GO:0051082,GO:0051087,GO:0051208,GO:0055007,GO:0062023,GO:0070062,GO:0071157,GO:0071285,GO:0071556,GO:0071682,GO:0090398,GO:1900026,GO:1901164,GO:1901224,GO:1990668,GO:2000510" "negative regulation of transcription by RNA polymerase II|acrosomal vesicle|complement component C1q complex binding|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|peptide antigen assembly with MHC class I protein complex|DNA binding|RNA binding|mRNA binding|integrin binding|iron ion binding|calcium ion binding|protein binding|extracellular region|extracellular space|nucleus|nuclear envelope|cytoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|smooth endoplasmic reticulum|Golgi apparatus|cytosol|polysome|focal adhesion|regulation of transcription, DNA-templated|protein folding|protein export from nucleus|cellular calcium ion homeostasis|receptor-mediated endocytosis|spermatogenesis|zinc ion binding|positive regulation of cell population proliferation|external side of plasma membrane|cell surface|positive regulation of endothelial cell migration|positive regulation of gene expression|membrane|negative regulation of translation|protein maturation by protein folding|carbohydrate binding|phagocytic vesicle membrane|cortical actin cytoskeleton organization|endoplasmic reticulum unfolded protein response|ubiquitin protein ligase binding|response to estradiol|sarcoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment membrane|negative regulation of intracellular steroid hormone receptor signaling pathway|response to testosterone|protein localization to nucleus|protein folding in endoplasmic reticulum|ATF6-mediated unfolded protein response|regulation of meiotic nuclear division|peptide binding|response to drug|hormone binding|MHC class I peptide loading complex|glucocorticoid receptor signaling pathway|regulation of apoptotic process|protein folding chaperone|endoplasmic reticulum quality control compartment|negative regulation of neuron differentiation|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|negative regulation of retinoic acid receptor signaling pathway|perinuclear region of cytoplasm|androgen receptor binding|positive regulation of phagocytosis|protein stabilization|unfolded protein binding|chaperone binding|sequestering of calcium ion|cardiac muscle cell differentiation|collagen-containing extracellular matrix|extracellular exosome|negative regulation of cell cycle arrest|cellular response to lithium ion|integral component of lumenal side of endoplasmic reticulum membrane|endocytic vesicle lumen|cellular senescence|positive regulation of substrate adhesion-dependent cell spreading|negative regulation of trophoblast cell migration|positive regulation of NIK/NF-kappaB signaling|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane|positive regulation of dendritic cell chemotaxis" "hsa04141,hsa04145,hsa04612,hsa05142,hsa05163,hsa05166,hsa05168,hsa05169,hsa05170" Protein processing in endoplasmic reticulum|Phagosome|Antigen processing and presentation|Chagas disease|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection CALU 15168.18028 13870.79788 16465.56268 1.18706673 0.247401037 0.346848188 1 143.1558673 167.0919256 813 calumenin "GO:0005509,GO:0005515,GO:0005576,GO:0005783,GO:0005788,GO:0005789,GO:0005794,GO:0008150,GO:0016020,GO:0033018,GO:0042470,GO:0043687,GO:0044267" calcium ion binding|protein binding|extracellular region|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi apparatus|biological_process|membrane|sarcoplasmic reticulum lumen|melanosome|post-translational protein modification|cellular protein metabolic process CAMK1 503.345739 446.3375557 560.3539223 1.255448741 0.328203126 0.229588863 1 14.42774986 17.81019884 8536 calcium/calmodulin dependent protein kinase I "GO:0004683,GO:0005515,GO:0005516,GO:0005524,GO:0005622,GO:0005634,GO:0005829,GO:0006468,GO:0006913,GO:0007049,GO:0007165,GO:0007399,GO:0010976,GO:0014069,GO:0018105,GO:0030154,GO:0032091,GO:0032880,GO:0033138,GO:0043393,GO:0045944,GO:0046827,GO:0051147,GO:0051149,GO:0051835,GO:0060143,GO:0060999,GO:0071902,GO:0098978,GO:1901985,GO:2000615" calmodulin-dependent protein kinase activity|protein binding|calmodulin binding|ATP binding|intracellular anatomical structure|nucleus|cytosol|protein phosphorylation|nucleocytoplasmic transport|cell cycle|signal transduction|nervous system development|positive regulation of neuron projection development|postsynaptic density|peptidyl-serine phosphorylation|cell differentiation|negative regulation of protein binding|regulation of protein localization|positive regulation of peptidyl-serine phosphorylation|regulation of protein binding|positive regulation of transcription by RNA polymerase II|positive regulation of protein export from nucleus|regulation of muscle cell differentiation|positive regulation of muscle cell differentiation|positive regulation of synapse structural plasticity|positive regulation of syncytium formation by plasma membrane fusion|positive regulation of dendritic spine development|positive regulation of protein serine/threonine kinase activity|glutamatergic synapse|positive regulation of protein acetylation|regulation of histone H3-K9 acetylation "hsa04020,hsa04921,hsa04925,hsa05214" Calcium signaling pathway|Oxytocin signaling pathway|Aldosterone synthesis and secretion|Glioma CAMK1D 14.69474208 7.282897178 22.10658699 3.035411107 1.601891924 0.106407389 1 0.081193824 0.242332518 57118 calcium/calmodulin dependent protein kinase ID "GO:0004683,GO:0005516,GO:0005524,GO:0005622,GO:0005634,GO:0005737,GO:0006954,GO:0007399,GO:0010976,GO:0018105,GO:0032793,GO:0043065,GO:0043066,GO:0050766,GO:0050773,GO:0060267,GO:0071622,GO:0090023" calmodulin-dependent protein kinase activity|calmodulin binding|ATP binding|intracellular anatomical structure|nucleus|cytoplasm|inflammatory response|nervous system development|positive regulation of neuron projection development|peptidyl-serine phosphorylation|positive regulation of CREB transcription factor activity|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of phagocytosis|regulation of dendrite development|positive regulation of respiratory burst|regulation of granulocyte chemotaxis|positive regulation of neutrophil chemotaxis "hsa04020,hsa04921,hsa04925,hsa05214" Calcium signaling pathway|Oxytocin signaling pathway|Aldosterone synthesis and secretion|Glioma CAMK1G 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.067521253 0.061333732 57172 calcium/calmodulin dependent protein kinase IG "GO:0000139,GO:0004683,GO:0005515,GO:0005516,GO:0005524,GO:0005622,GO:0005886,GO:0005954,GO:0018105,GO:0043005" Golgi membrane|calmodulin-dependent protein kinase activity|protein binding|calmodulin binding|ATP binding|intracellular anatomical structure|plasma membrane|calcium- and calmodulin-dependent protein kinase complex|peptidyl-serine phosphorylation|neuron projection "hsa04020,hsa04921,hsa04925,hsa05214" Calcium signaling pathway|Oxytocin signaling pathway|Aldosterone synthesis and secretion|Glioma CAMK2B 17.85561269 14.56579436 21.14543103 1.451718356 0.537761587 0.578658858 1 0.15707207 0.224208727 816 calcium/calmodulin dependent protein kinase II beta "GO:0003779,GO:0004683,GO:0005515,GO:0005516,GO:0005524,GO:0005654,GO:0005737,GO:0005815,GO:0005829,GO:0005954,GO:0006468,GO:0007165,GO:0010976,GO:0014733,GO:0030666,GO:0033017,GO:0042802,GO:0042803,GO:0043005,GO:0045202,GO:0046777,GO:0048169,GO:0051823,GO:0051924,GO:0060333,GO:0060998,GO:0061003,GO:0090129,GO:1900034,GO:2001222" actin binding|calmodulin-dependent protein kinase activity|protein binding|calmodulin binding|ATP binding|nucleoplasm|cytoplasm|microtubule organizing center|cytosol|calcium- and calmodulin-dependent protein kinase complex|protein phosphorylation|signal transduction|positive regulation of neuron projection development|regulation of skeletal muscle adaptation|endocytic vesicle membrane|sarcoplasmic reticulum membrane|identical protein binding|protein homodimerization activity|neuron projection|synapse|protein autophosphorylation|regulation of long-term neuronal synaptic plasticity|regulation of synapse structural plasticity|regulation of calcium ion transport|interferon-gamma-mediated signaling pathway|regulation of dendritic spine development|positive regulation of dendritic spine morphogenesis|positive regulation of synapse maturation|regulation of cellular response to heat|regulation of neuron migration "hsa04012,hsa04020,hsa04024,hsa04066,hsa04114,hsa04217,hsa04261,hsa04310,hsa04360,hsa04713,hsa04720,hsa04722,hsa04725,hsa04728,hsa04740,hsa04750,hsa04911,hsa04912,hsa04916,hsa04921,hsa04922,hsa04925,hsa04934,hsa04971,hsa05012,hsa05022,hsa05031,hsa05152,hsa05200,hsa05205,hsa05214" ErbB signaling pathway|Calcium signaling pathway|cAMP signaling pathway|HIF-1 signaling pathway|Oocyte meiosis|Necroptosis|Adrenergic signaling in cardiomyocytes|Wnt signaling pathway|Axon guidance|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Olfactory transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Aldosterone synthesis and secretion|Cushing syndrome|Gastric acid secretion|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Tuberculosis|Pathways in cancer|Proteoglycans in cancer|Glioma CAMK2D 962.2103477 961.3424276 963.0782679 1.001805642 0.002602642 0.996431273 1 7.488699239 7.376681639 817 calcium/calmodulin dependent protein kinase II delta "GO:0001558,GO:0002026,GO:0003254,GO:0004674,GO:0004683,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005954,GO:0006357,GO:0006468,GO:0008016,GO:0010613,GO:0010649,GO:0010666,GO:0010880,GO:0010881,GO:0016020,GO:0018105,GO:0018107,GO:0019871,GO:0030666,GO:0031432,GO:0032469,GO:0033017,GO:0042383,GO:0042802,GO:0042803,GO:0043005,GO:0044325,GO:0046777,GO:0055119,GO:0060314,GO:0060333,GO:0060341,GO:0071277,GO:0086003,GO:0086091,GO:0098901,GO:0098909,GO:1900034,GO:1901725,GO:1901844,GO:1901897,GO:1902306,GO:1902514,GO:2000650" regulation of cell growth|regulation of the force of heart contraction|regulation of membrane depolarization|protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|protein binding|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|calcium- and calmodulin-dependent protein kinase complex|regulation of transcription by RNA polymerase II|protein phosphorylation|regulation of heart contraction|positive regulation of cardiac muscle hypertrophy|regulation of cell communication by electrical coupling|positive regulation of cardiac muscle cell apoptotic process|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|membrane|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|sodium channel inhibitor activity|endocytic vesicle membrane|titin binding|endoplasmic reticulum calcium ion homeostasis|sarcoplasmic reticulum membrane|sarcolemma|identical protein binding|protein homodimerization activity|neuron projection|ion channel binding|protein autophosphorylation|relaxation of cardiac muscle|regulation of ryanodine-sensitive calcium-release channel activity|interferon-gamma-mediated signaling pathway|regulation of cellular localization|cellular response to calcium ion|cardiac muscle cell contraction|regulation of heart rate by cardiac conduction|regulation of cardiac muscle cell action potential|regulation of cardiac muscle cell action potential involved in regulation of contraction|regulation of cellular response to heat|regulation of histone deacetylase activity|regulation of cell communication by electrical coupling involved in cardiac conduction|regulation of relaxation of cardiac muscle|negative regulation of sodium ion transmembrane transport|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|negative regulation of sodium ion transmembrane transporter activity "hsa04012,hsa04020,hsa04024,hsa04066,hsa04114,hsa04217,hsa04261,hsa04310,hsa04360,hsa04713,hsa04720,hsa04722,hsa04725,hsa04728,hsa04740,hsa04750,hsa04911,hsa04912,hsa04916,hsa04921,hsa04922,hsa04925,hsa04934,hsa04971,hsa05012,hsa05022,hsa05031,hsa05152,hsa05200,hsa05205,hsa05214" ErbB signaling pathway|Calcium signaling pathway|cAMP signaling pathway|HIF-1 signaling pathway|Oocyte meiosis|Necroptosis|Adrenergic signaling in cardiomyocytes|Wnt signaling pathway|Axon guidance|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Olfactory transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Aldosterone synthesis and secretion|Cushing syndrome|Gastric acid secretion|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Tuberculosis|Pathways in cancer|Proteoglycans in cancer|Glioma CAMK2G 1960.914439 1997.594655 1924.234224 0.963275617 -0.053979447 0.821424643 1 20.37613824 19.29939187 818 calcium/calmodulin dependent protein kinase II gamma "GO:0004683,GO:0004723,GO:0005515,GO:0005516,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0005954,GO:0006468,GO:0006470,GO:0007399,GO:0010975,GO:0014733,GO:0016020,GO:0030073,GO:0030154,GO:0030666,GO:0033017,GO:0042802,GO:0042803,GO:0043005,GO:0051924,GO:0060333,GO:1900034" calmodulin-dependent protein kinase activity|calcium-dependent protein serine/threonine phosphatase activity|protein binding|calmodulin binding|ATP binding|nucleoplasm|cytoplasm|cytosol|calcium- and calmodulin-dependent protein kinase complex|protein phosphorylation|protein dephosphorylation|nervous system development|regulation of neuron projection development|regulation of skeletal muscle adaptation|membrane|insulin secretion|cell differentiation|endocytic vesicle membrane|sarcoplasmic reticulum membrane|identical protein binding|protein homodimerization activity|neuron projection|regulation of calcium ion transport|interferon-gamma-mediated signaling pathway|regulation of cellular response to heat "hsa04012,hsa04020,hsa04024,hsa04066,hsa04114,hsa04217,hsa04261,hsa04310,hsa04360,hsa04713,hsa04720,hsa04722,hsa04725,hsa04728,hsa04740,hsa04750,hsa04911,hsa04912,hsa04916,hsa04921,hsa04922,hsa04925,hsa04934,hsa04971,hsa05012,hsa05022,hsa05031,hsa05152,hsa05200,hsa05205,hsa05214" ErbB signaling pathway|Calcium signaling pathway|cAMP signaling pathway|HIF-1 signaling pathway|Oocyte meiosis|Necroptosis|Adrenergic signaling in cardiomyocytes|Wnt signaling pathway|Axon guidance|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Olfactory transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Aldosterone synthesis and secretion|Cushing syndrome|Gastric acid secretion|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Tuberculosis|Pathways in cancer|Proteoglycans in cancer|Glioma CAMK2N1 464.0874142 374.5489978 553.6258307 1.478113235 0.563756795 0.042807702 1 8.593719526 12.48993159 55450 calcium/calmodulin dependent protein kinase II inhibitor 1 "GO:0003084,GO:0005575,GO:0006469,GO:0008285,GO:0008427,GO:0010628,GO:0014069,GO:0019901,GO:0030425,GO:0035774,GO:0043025,GO:0045786,GO:0045861,GO:0055074,GO:0070373,GO:1904030" positive regulation of systemic arterial blood pressure|cellular_component|negative regulation of protein kinase activity|negative regulation of cell population proliferation|calcium-dependent protein kinase inhibitor activity|positive regulation of gene expression|postsynaptic density|protein kinase binding|dendrite|positive regulation of insulin secretion involved in cellular response to glucose stimulus|neuronal cell body|negative regulation of cell cycle|negative regulation of proteolysis|calcium ion homeostasis|negative regulation of ERK1 and ERK2 cascade|negative regulation of cyclin-dependent protein kinase activity CAMK2N2 104.4087242 91.55642167 117.2610266 1.280751524 0.356990609 0.445397608 1 3.365150104 4.237800433 94032 calcium/calmodulin dependent protein kinase II inhibitor 2 "GO:0005654,GO:0005813,GO:0005829,GO:0006469,GO:0008427,GO:0019901" nucleoplasm|centrosome|cytosol|negative regulation of protein kinase activity|calcium-dependent protein kinase inhibitor activity|protein kinase binding CAMK4 673.8603737 671.0669543 676.653793 1.008325307 0.011961158 0.969399421 1 2.95467453 2.929419004 814 calcium/calmodulin dependent protein kinase IV "GO:0001650,GO:0002250,GO:0002372,GO:0004683,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006468,GO:0006954,GO:0007165,GO:0007616,GO:0009931,GO:0018105,GO:0033081,GO:0035556,GO:0043011,GO:0045670,GO:0045893,GO:0046777,GO:0070062,GO:0098794,GO:0098978" "fibrillar center|adaptive immune response|myeloid dendritic cell cytokine production|calmodulin-dependent protein kinase activity|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|protein phosphorylation|inflammatory response|signal transduction|long-term memory|calcium-dependent protein serine/threonine kinase activity|peptidyl-serine phosphorylation|regulation of T cell differentiation in thymus|intracellular signal transduction|myeloid dendritic cell differentiation|regulation of osteoclast differentiation|positive regulation of transcription, DNA-templated|protein autophosphorylation|extracellular exosome|postsynapse|glutamatergic synapse" "hsa04020,hsa04024,hsa04211,hsa04371,hsa04380,hsa04720,hsa04722,hsa04725,hsa04921,hsa04925,hsa05031,hsa05034,hsa05214" Calcium signaling pathway|cAMP signaling pathway|Longevity regulating pathway|Apelin signaling pathway|Osteoclast differentiation|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Oxytocin signaling pathway|Aldosterone synthesis and secretion|Amphetamine addiction|Alcoholism|Glioma CAMKK1 155.7953549 178.9511878 132.6395219 0.741205038 -0.432055408 0.281473943 1 1.267457995 0.923725891 84254 calcium/calmodulin dependent protein kinase kinase 1 "GO:0004674,GO:0004683,GO:0005515,GO:0005516,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0035556,GO:0045860" protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|protein binding|calmodulin binding|ATP binding|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|intracellular signal transduction|positive regulation of protein kinase activity hsa05034 Alcoholism CAMKK2 1422.442463 1461.781505 1383.103421 0.946176577 -0.079818648 0.740852965 1 14.30111683 13.30495242 10645 calcium/calmodulin dependent protein kinase kinase 2 "GO:0000165,GO:0001934,GO:0004683,GO:0004713,GO:0005509,GO:0005516,GO:0005524,GO:0005654,GO:0005829,GO:0006468,GO:0018108,GO:0019722,GO:0034614,GO:0043005,GO:0045859,GO:0045893,GO:0046777,GO:0061762,GO:1903599" "MAPK cascade|positive regulation of protein phosphorylation|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity|calcium ion binding|calmodulin binding|ATP binding|nucleoplasm|cytosol|protein phosphorylation|peptidyl-tyrosine phosphorylation|calcium-mediated signaling|cellular response to reactive oxygen species|neuron projection|regulation of protein kinase activity|positive regulation of transcription, DNA-templated|protein autophosphorylation|CAMKK-AMPK signaling cascade|positive regulation of autophagy of mitochondrion" "hsa04140,hsa04152,hsa04211,hsa04920,hsa04921,hsa05034" Autophagy - animal|AMPK signaling pathway|Longevity regulating pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Alcoholism CAMKMT 62.20718085 68.66731625 55.74704545 0.811842496 -0.300728234 0.602518446 1 0.204786167 0.163472076 79823 calmodulin-lysine N-methyltransferase "GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006479,GO:0007005,GO:0018022,GO:0018025,GO:0022400,GO:0031072,GO:0032991" nucleoplasm|cytoplasm|Golgi apparatus|cytosol|protein methylation|mitochondrion organization|peptidyl-lysine methylation|calmodulin-lysine N-methyltransferase activity|regulation of rhodopsin mediated signaling pathway|heat shock protein binding|protein-containing complex hsa00310 Lysine degradation CAMLG 1438.773896 1183.990998 1693.556794 1.430379789 0.516398257 0.03098549 0.895820653 29.1052158 40.93486545 819 calcium modulating ligand "GO:0005515,GO:0005737,GO:0005783,GO:0006952,GO:0007165,GO:0016020,GO:0016021,GO:0016032,GO:0031397,GO:0031625,GO:0032435,GO:0050821,GO:0050839" protein binding|cytoplasm|endoplasmic reticulum|defense response|signal transduction|membrane|integral component of membrane|viral process|negative regulation of protein ubiquitination|ubiquitin protein ligase binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|cell adhesion molecule binding CAMSAP1 1707.076146 1831.128433 1583.02386 0.864507279 -0.210049984 0.376686886 1 12.21244177 10.38107524 157922 calmodulin regulated spectrin associated protein 1 "GO:0000226,GO:0005516,GO:0005737,GO:0005874,GO:0007010,GO:0007026,GO:0008017,GO:0022604,GO:0030507,GO:0031113,GO:0031122,GO:0031175,GO:0036449,GO:0051011" microtubule cytoskeleton organization|calmodulin binding|cytoplasm|microtubule|cytoskeleton organization|negative regulation of microtubule depolymerization|microtubule binding|regulation of cell morphogenesis|spectrin binding|regulation of microtubule polymerization|cytoplasmic microtubule organization|neuron projection development|microtubule minus-end|microtubule minus-end binding CAMSAP2 2062.359209 2288.910542 1835.807876 0.802044397 -0.318245995 0.178472694 1 15.1688748 11.96252766 23271 calmodulin regulated spectrin associated protein family member 2 "GO:0000226,GO:0005515,GO:0005516,GO:0005794,GO:0005813,GO:0005829,GO:0007026,GO:0030507,GO:0031113,GO:0031122,GO:0033043,GO:0036064,GO:0036449,GO:0050773,GO:0051011,GO:0061564,GO:1903358,GO:1990752" microtubule cytoskeleton organization|protein binding|calmodulin binding|Golgi apparatus|centrosome|cytosol|negative regulation of microtubule depolymerization|spectrin binding|regulation of microtubule polymerization|cytoplasmic microtubule organization|regulation of organelle organization|ciliary basal body|microtubule minus-end|regulation of dendrite development|microtubule minus-end binding|axon development|regulation of Golgi organization|microtubule end CAMSAP3 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.01312337 0.035762306 57662 calmodulin regulated spectrin associated protein family member 3 "GO:0000226,GO:0001701,GO:0003341,GO:0005515,GO:0005516,GO:0005654,GO:0005737,GO:0005813,GO:0005915,GO:0005930,GO:0007026,GO:0009792,GO:0010923,GO:0030334,GO:0030507,GO:0030951,GO:0031113,GO:0031122,GO:0031175,GO:0031514,GO:0033043,GO:0034453,GO:0036064,GO:0036449,GO:0045198,GO:0045218,GO:0051011,GO:0051015,GO:0051893,GO:0070507,GO:0090136,GO:0098840,GO:1903358" microtubule cytoskeleton organization|in utero embryonic development|cilium movement|protein binding|calmodulin binding|nucleoplasm|cytoplasm|centrosome|zonula adherens|axoneme|negative regulation of microtubule depolymerization|embryo development ending in birth or egg hatching|negative regulation of phosphatase activity|regulation of cell migration|spectrin binding|establishment or maintenance of microtubule cytoskeleton polarity|regulation of microtubule polymerization|cytoplasmic microtubule organization|neuron projection development|motile cilium|regulation of organelle organization|microtubule anchoring|ciliary basal body|microtubule minus-end|establishment of epithelial cell apical/basal polarity|zonula adherens maintenance|microtubule minus-end binding|actin filament binding|regulation of focal adhesion assembly|regulation of microtubule cytoskeleton organization|epithelial cell-cell adhesion|protein transport along microtubule|regulation of Golgi organization CAMTA1 441.1284973 402.6401726 479.616822 1.191179755 0.252391139 0.372269572 1 1.144570469 1.340574699 23261 calmodulin binding transcription activator 1 "GO:0003690,GO:0003712,GO:0005634,GO:0005730,GO:0005829,GO:0006357,GO:0035307,GO:0070886" double-stranded DNA binding|transcription coregulator activity|nucleus|nucleolus|cytosol|regulation of transcription by RNA polymerase II|positive regulation of protein dephosphorylation|positive regulation of calcineurin-NFAT signaling cascade CAMTA2 1232.085123 1283.870731 1180.299514 0.919328937 -0.121346944 0.617281105 1 14.64995109 13.24275315 23125 calmodulin binding transcription activator 2 "GO:0000785,GO:0003682,GO:0003690,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0006357,GO:0008134,GO:0014898,GO:0042826,GO:0043565,GO:0045944" chromatin|chromatin binding|double-stranded DNA binding|transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|transcription factor binding|cardiac muscle hypertrophy in response to stress|histone deacetylase binding|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II CG_1 CAND1 4160.824589 4024.320898 4297.328279 1.067839367 0.094694641 0.691796838 1 18.81806799 19.75841665 55832 cullin associated and neddylation dissociated 1 "GO:0000151,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006879,GO:0010265,GO:0016020,GO:0016567,GO:0017025,GO:0030154,GO:0031461,GO:0034774,GO:0043086,GO:0043312,GO:0043687,GO:0045899,GO:0070062,GO:1904813" ubiquitin ligase complex|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|cellular iron ion homeostasis|SCF complex assembly|membrane|protein ubiquitination|TBP-class protein binding|cell differentiation|cullin-RING ubiquitin ligase complex|secretory granule lumen|negative regulation of catalytic activity|neutrophil degranulation|post-translational protein modification|positive regulation of RNA polymerase II transcription preinitiation complex assembly|extracellular exosome|ficolin-1-rich granule lumen CAND2 239.8763793 228.8910542 250.8617045 1.09598737 0.132231173 0.706139468 1 2.372401413 2.556612466 23066 cullin associated and neddylation dissociated 2 (putative) "GO:0005515,GO:0005634,GO:0005829,GO:0010265,GO:0016567,GO:0017025,GO:0045893" "protein binding|nucleus|cytosol|SCF complex assembly|protein ubiquitination|TBP-class protein binding|positive regulation of transcription, DNA-templated" CANT1 2972.589106 3046.331848 2898.846363 0.951585877 -0.071594235 0.763304482 1 42.30474417 39.58295744 124583 calcium activated nucleotidase 1 "GO:0004382,GO:0005509,GO:0005515,GO:0005576,GO:0005789,GO:0005794,GO:0005886,GO:0016020,GO:0016021,GO:0030166,GO:0032580,GO:0035580,GO:0042803,GO:0043123,GO:0043262,GO:0043312,GO:0045134,GO:0070062,GO:1904724,GO:1904813" guanosine-diphosphatase activity|calcium ion binding|protein binding|extracellular region|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|membrane|integral component of membrane|proteoglycan biosynthetic process|Golgi cisterna membrane|specific granule lumen|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|adenosine-diphosphatase activity|neutrophil degranulation|uridine-diphosphatase activity|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen "hsa00230,hsa00240" Purine metabolism|Pyrimidine metabolism CANX 15494.91194 15812.21019 15177.6137 0.95986668 -0.059094057 0.822787068 1 162.8461204 153.6949194 821 calnexin "GO:0002474,GO:0003723,GO:0005509,GO:0005515,GO:0005783,GO:0005788,GO:0005789,GO:0006457,GO:0009306,GO:0016020,GO:0016032,GO:0019886,GO:0030246,GO:0030968,GO:0034975,GO:0042470,GO:0044233,GO:0048488,GO:0051082,GO:0070062,GO:0070106,GO:0070757,GO:0071556,GO:0072583,GO:0098793" antigen processing and presentation of peptide antigen via MHC class I|RNA binding|calcium ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|protein folding|protein secretion|membrane|viral process|antigen processing and presentation of exogenous peptide antigen via MHC class II|carbohydrate binding|endoplasmic reticulum unfolded protein response|protein folding in endoplasmic reticulum|melanosome|mitochondria-associated endoplasmic reticulum membrane|synaptic vesicle endocytosis|unfolded protein binding|extracellular exosome|interleukin-27-mediated signaling pathway|interleukin-35-mediated signaling pathway|integral component of lumenal side of endoplasmic reticulum membrane|clathrin-dependent endocytosis|presynapse "hsa04141,hsa04145,hsa04612,hsa04918,hsa05166" Protein processing in endoplasmic reticulum|Phagosome|Antigen processing and presentation|Thyroid hormone synthesis|Human T-cell leukemia virus 1 infection CAP1 12403.12356 11314.50097 13491.74615 1.192429625 0.253904124 0.322863236 1 187.642673 220.0065176 10487 cyclase associated actin cytoskeleton regulatory protein 1 "GO:0000902,GO:0001667,GO:0003779,GO:0005576,GO:0005737,GO:0005886,GO:0005925,GO:0006898,GO:0007163,GO:0007165,GO:0007190,GO:0008179,GO:0019933,GO:0030036,GO:0030864,GO:0035578,GO:0043312,GO:0045761,GO:0070062" cell morphogenesis|ameboidal-type cell migration|actin binding|extracellular region|cytoplasm|plasma membrane|focal adhesion|receptor-mediated endocytosis|establishment or maintenance of cell polarity|signal transduction|activation of adenylate cyclase activity|adenylate cyclase binding|cAMP-mediated signaling|actin cytoskeleton organization|cortical actin cytoskeleton|azurophil granule lumen|neutrophil degranulation|regulation of adenylate cyclase activity|extracellular exosome CAP2 481.6253808 481.7116277 481.539134 0.999641915 -0.0005167 1 1 8.789081785 8.63891383 10486 cyclase associated actin cytoskeleton regulatory protein 2 "GO:0000902,GO:0003779,GO:0005515,GO:0005737,GO:0005886,GO:0007010,GO:0007163,GO:0007165,GO:0007190,GO:0008179,GO:0014069,GO:0019933,GO:0042802,GO:0045761" cell morphogenesis|actin binding|protein binding|cytoplasm|plasma membrane|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction|activation of adenylate cyclase activity|adenylate cyclase binding|postsynaptic density|cAMP-mediated signaling|identical protein binding|regulation of adenylate cyclase activity CAPG 4400.924879 4095.069042 4706.780717 1.149377622 0.200852865 0.400547048 1 131.9724084 149.1478709 822 "capping actin protein, gelsolin like" "GO:0001726,GO:0005515,GO:0005546,GO:0005615,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005814,GO:0007417,GO:0008154,GO:0008290,GO:0015629,GO:0019904,GO:0022617,GO:0030027,GO:0030031,GO:0042470,GO:0044877,GO:0045296,GO:0051014,GO:0051015,GO:0051016,GO:0065003,GO:0070062,GO:0071803,GO:0072686,GO:0090543" "ruffle|protein binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular space|nucleus|nucleoplasm|nucleolus|cytoplasm|centriole|central nervous system development|actin polymerization or depolymerization|F-actin capping protein complex|actin cytoskeleton|protein domain specific binding|extracellular matrix disassembly|lamellipodium|cell projection assembly|melanosome|protein-containing complex binding|cadherin binding|actin filament severing|actin filament binding|barbed-end actin filament capping|protein-containing complex assembly|extracellular exosome|positive regulation of podosome assembly|mitotic spindle|Flemming body" CAPN1 4439.994506 4237.605744 4642.383267 1.095520336 0.131616265 0.582072493 1 70.16854799 75.58473798 823 calpain 1 "GO:0004198,GO:0005509,GO:0005515,GO:0005576,GO:0005737,GO:0005739,GO:0005764,GO:0005829,GO:0005886,GO:0005925,GO:0006508,GO:0008233,GO:0008284,GO:0016020,GO:0016241,GO:0022617,GO:0032801,GO:0043312,GO:0050790,GO:0060056,GO:0070062,GO:0070268,GO:0097264,GO:1904813,GO:2000310" calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|protein binding|extracellular region|cytoplasm|mitochondrion|lysosome|cytosol|plasma membrane|focal adhesion|proteolysis|peptidase activity|positive regulation of cell population proliferation|membrane|regulation of macroautophagy|extracellular matrix disassembly|receptor catabolic process|neutrophil degranulation|regulation of catalytic activity|mammary gland involution|extracellular exosome|cornification|self proteolysis|ficolin-1-rich granule lumen|regulation of NMDA receptor activity "hsa04141,hsa04210,hsa04217,hsa04218,hsa05010,hsa05022,hsa05131" Protein processing in endoplasmic reticulum|Apoptosis|Necroptosis|Cellular senescence|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Shigellosis CAPN10 358.2464026 358.9427895 357.5500156 0.996119789 -0.00560885 0.995716429 1 7.308705443 7.158519389 11132 calpain 10 "GO:0000149,GO:0004198,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006508,GO:0006921,GO:0008092,GO:0031532,GO:0032024,GO:0032388,GO:0032869,GO:0046326,GO:0097050,GO:2000676" SNARE binding|calcium-dependent cysteine-type endopeptidase activity|protein binding|cytoplasm|mitochondrion|cytosol|plasma membrane|proteolysis|cellular component disassembly involved in execution phase of apoptosis|cytoskeletal protein binding|actin cytoskeleton reorganization|positive regulation of insulin secretion|positive regulation of intracellular transport|cellular response to insulin stimulus|positive regulation of glucose import|type B pancreatic cell apoptotic process|positive regulation of type B pancreatic cell apoptotic process CAPN11 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.058141337 0.017604458 11131 calpain 11 "GO:0001669,GO:0004198,GO:0005509,GO:0005737,GO:0006508,GO:0008233" acrosomal vesicle|calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|cytoplasm|proteolysis|peptidase activity CAPN12 36.0282571 37.45489978 34.60161442 0.923820772 -0.11431511 0.907392187 1 0.653021614 0.593179943 147968 calpain 12 "GO:0004198,GO:0005509,GO:0005737,GO:0006508" calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|cytoplasm|proteolysis CAPN14 15.76975451 22.88910542 8.650403604 0.377926679 -1.403821727 0.139520198 1 0.29714169 0.110418621 440854 calpain 14 "GO:0004198,GO:0005509,GO:0005737,GO:0006508" calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|cytoplasm|proteolysis CAPN15 816.3480002 879.1497308 753.5462695 0.857130752 -0.222412797 0.376484262 1 5.037969003 4.24593896 6650 calpain 15 "GO:0004198,GO:0005515,GO:0005737,GO:0006508,GO:0046872" calcium-dependent cysteine-type endopeptidase activity|protein binding|cytoplasm|proteolysis|metal ion binding CAPN2 15926.0132 16948.34215 14903.68425 0.879359416 -0.185475144 0.483325396 1 251.1807472 217.1820584 824 calpain 2 "GO:0000785,GO:0001666,GO:0001824,GO:0004198,GO:0005509,GO:0005515,GO:0005634,GO:0005737,GO:0005758,GO:0005764,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0005925,GO:0006508,GO:0007520,GO:0007565,GO:0008092,GO:0008234,GO:0009897,GO:0010666,GO:0019899,GO:0022617,GO:0030425,GO:0030864,GO:0031143,GO:0032675,GO:0035458,GO:0042542,GO:0043025,GO:0044877,GO:0045121,GO:0048266,GO:0051493,GO:0051603,GO:0070062,GO:0071222,GO:0071230,GO:0097038,GO:1901216,GO:1901741,GO:2001247" chromatin|response to hypoxia|blastocyst development|calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|protein binding|nucleus|cytoplasm|mitochondrial intermembrane space|lysosome|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|focal adhesion|proteolysis|myoblast fusion|female pregnancy|cytoskeletal protein binding|cysteine-type peptidase activity|external side of plasma membrane|positive regulation of cardiac muscle cell apoptotic process|enzyme binding|extracellular matrix disassembly|dendrite|cortical actin cytoskeleton|pseudopodium|regulation of interleukin-6 production|cellular response to interferon-beta|response to hydrogen peroxide|neuronal cell body|protein-containing complex binding|membrane raft|behavioral response to pain|regulation of cytoskeleton organization|proteolysis involved in cellular protein catabolic process|extracellular exosome|cellular response to lipopolysaccharide|cellular response to amino acid stimulus|perinuclear endoplasmic reticulum|positive regulation of neuron death|positive regulation of myoblast fusion|positive regulation of phosphatidylcholine biosynthetic process "hsa04141,hsa04210,hsa04217,hsa04218,hsa04510,hsa05010,hsa05022,hsa05131" Protein processing in endoplasmic reticulum|Apoptosis|Necroptosis|Cellular senescence|Focal adhesion|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Shigellosis CAPN3 7.644588267 11.44455271 3.844623824 0.335934826 -1.573746729 0.246344754 1 0.165118882 0.054540981 825 calpain 3 "GO:0003824,GO:0004198,GO:0005509,GO:0005515,GO:0005622,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006915,GO:0007517,GO:0008233,GO:0008234,GO:0008307,GO:0014718,GO:0014850,GO:0030016,GO:0030018,GO:0030163,GO:0030239,GO:0030315,GO:0031402,GO:0031432,GO:0031648,GO:0032991,GO:0033234,GO:0043066,GO:0043122,GO:0045214,GO:0045661,GO:0045862,GO:0045892,GO:0045893,GO:0046716,GO:0050790,GO:0051092,GO:0051281,GO:0051592,GO:0055103,GO:0060090,GO:0061061,GO:0065003,GO:0070315,GO:0071277,GO:0071472,GO:0072657,GO:0097264,GO:1990092" "catalytic activity|calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|protein binding|intracellular anatomical structure|nucleus|cytoplasm|cytosol|plasma membrane|proteolysis|apoptotic process|muscle organ development|peptidase activity|cysteine-type peptidase activity|structural constituent of muscle|positive regulation of satellite cell activation involved in skeletal muscle regeneration|response to muscle activity|myofibril|Z disc|protein catabolic process|myofibril assembly|T-tubule|sodium ion binding|titin binding|protein destabilization|protein-containing complex|negative regulation of protein sumoylation|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|sarcomere organization|regulation of myoblast differentiation|positive regulation of proteolysis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|muscle cell cellular homeostasis|regulation of catalytic activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion|ligase regulator activity|molecular adaptor activity|muscle structure development|protein-containing complex assembly|G1 to G0 transition involved in cell differentiation|cellular response to calcium ion|cellular response to salt stress|protein localization to membrane|self proteolysis|calcium-dependent self proteolysis" CAPN5 1175.738612 1280.74949 1070.727735 0.836016523 -0.258396639 0.286864478 1 14.91733879 12.26245404 726 calpain 5 "GO:0004198,GO:0005737,GO:0005925,GO:0006508,GO:0007165,GO:0009986,GO:0070062" calcium-dependent cysteine-type endopeptidase activity|cytoplasm|focal adhesion|proteolysis|signal transduction|cell surface|extracellular exosome CAPN6 10.04747816 11.44455271 8.650403604 0.755853359 -0.403821727 0.795727704 1 0.172926032 0.128519522 827 calpain 6 "GO:0001578,GO:0004198,GO:0005515,GO:0005737,GO:0005876,GO:0006508,GO:0008017,GO:0048471,GO:0051493" microtubule bundle formation|calcium-dependent cysteine-type endopeptidase activity|protein binding|cytoplasm|spindle microtubule|proteolysis|microtubule binding|perinuclear region of cytoplasm|regulation of cytoskeleton organization CAPN7 756.0090254 745.9767539 766.0412969 1.026897008 0.038291495 0.885086506 1 10.1845506 10.28347597 23473 calpain 7 "GO:0004175,GO:0004198,GO:0005515,GO:0005634,GO:0005813,GO:0005829,GO:0010634,GO:0070062,GO:0090541,GO:0097264" endopeptidase activity|calcium-dependent cysteine-type endopeptidase activity|protein binding|nucleus|centrosome|cytosol|positive regulation of epithelial cell migration|extracellular exosome|MIT domain binding|self proteolysis CAPNS1 5726.106193 4921.157665 6531.054721 1.327137874 0.408318258 0.09126061 1 117.1946184 152.9307756 826 calpain small subunit 1 "GO:0004198,GO:0005509,GO:0005515,GO:0005829,GO:0005886,GO:0006508,GO:0008284,GO:0016020,GO:0016241,GO:0022617,GO:0070062,GO:0070268" calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|protein binding|cytosol|plasma membrane|proteolysis|positive regulation of cell population proliferation|membrane|regulation of macroautophagy|extracellular matrix disassembly|extracellular exosome|cornification hsa05131 Shigellosis CAPRIN1 7747.125635 7235.03814 8259.21313 1.141557649 0.191003718 0.437774174 1 56.67410657 63.6141472 4076 cell cycle associated protein 1 "GO:0000932,GO:0003723,GO:0005515,GO:0005737,GO:0005829,GO:0010494,GO:0016020,GO:0017148,GO:0030027,GO:0030425,GO:0031252,GO:0045202,GO:0050775,GO:0061003" P-body|RNA binding|protein binding|cytoplasm|cytosol|cytoplasmic stress granule|membrane|negative regulation of translation|lamellipodium|dendrite|cell leading edge|synapse|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis CAPRIN2 2613.402283 2536.529046 2690.275521 1.060612937 0.084898251 0.720593676 1 27.07939453 28.2401532 65981 caprin family member 2 "GO:0003723,GO:0005102,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005813,GO:0005829,GO:0005886,GO:0017148,GO:0030308,GO:0032092,GO:0033138,GO:0043235,GO:0045944,GO:0046872,GO:0050775,GO:0061003,GO:0090263" RNA binding|signaling receptor binding|protein binding|nucleoplasm|cytoplasm|mitochondrion|centrosome|cytosol|plasma membrane|negative regulation of translation|negative regulation of cell growth|positive regulation of protein binding|positive regulation of peptidyl-serine phosphorylation|receptor complex|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of canonical Wnt signaling pathway CAPS 35.86974124 33.29324424 38.44623824 1.154775965 0.207612985 0.794448243 1 1.220329159 1.385625614 828 calcyphosine "GO:0005509,GO:0005737,GO:0031982,GO:0035556" calcium ion binding|cytoplasm|vesicle|intracellular signal transduction CAPS2 250.2855486 237.2143652 263.3567319 1.110205664 0.150826959 0.660232697 1 2.376514866 2.594269876 84698 calcyphosine 2 GO:0005509 calcium ion binding CAPSL 7.406814487 5.202069413 9.61155956 1.847641543 0.88568489 0.555147706 1 0.234877228 0.426707042 133690 calcyphosine like "GO:0005509,GO:0005737" calcium ion binding|cytoplasm CAPZA1 7580.813513 6817.832173 8343.794854 1.223819338 0.291390601 0.235846369 1 142.2420533 171.1656063 829 capping actin protein of muscle Z-line subunit alpha 1 "GO:0003779,GO:0005515,GO:0005576,GO:0005829,GO:0005856,GO:0006888,GO:0007596,GO:0008290,GO:0015629,GO:0019886,GO:0030036,GO:0034329,GO:0035722,GO:0045087,GO:0045296,GO:0051015,GO:0051016,GO:0065003,GO:0070062,GO:0071203" actin binding|protein binding|extracellular region|cytosol|cytoskeleton|endoplasmic reticulum to Golgi vesicle-mediated transport|blood coagulation|F-actin capping protein complex|actin cytoskeleton|antigen processing and presentation of exogenous peptide antigen via MHC class II|actin cytoskeleton organization|cell junction assembly|interleukin-12-mediated signaling pathway|innate immune response|cadherin binding|actin filament binding|barbed-end actin filament capping|protein-containing complex assembly|extracellular exosome|WASH complex hsa04144 Endocytosis CAPZA2 2071.140403 1964.30141 2177.979396 1.108780651 0.148973987 0.52951633 1 20.68491635 22.55124826 830 capping actin protein of muscle Z-line subunit alpha 2 "GO:0005515,GO:0005576,GO:0005829,GO:0005903,GO:0006888,GO:0007596,GO:0008290,GO:0015629,GO:0016020,GO:0019886,GO:0030036,GO:0030863,GO:0045087,GO:0051015,GO:0051016,GO:0065003,GO:0070062" protein binding|extracellular region|cytosol|brush border|endoplasmic reticulum to Golgi vesicle-mediated transport|blood coagulation|F-actin capping protein complex|actin cytoskeleton|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|actin cytoskeleton organization|cortical cytoskeleton|innate immune response|actin filament binding|barbed-end actin filament capping|protein-containing complex assembly|extracellular exosome hsa04144 Endocytosis CAPZB 2638.046353 2401.275241 2874.817464 1.197204475 0.259669577 0.272212763 1 33.32942686 39.23443072 832 capping actin protein of muscle Z-line subunit beta "GO:0000902,GO:0003779,GO:0005515,GO:0005829,GO:0005856,GO:0006888,GO:0007010,GO:0007596,GO:0008290,GO:0010591,GO:0015629,GO:0019886,GO:0022604,GO:0030017,GO:0030036,GO:0045296,GO:0051015,GO:0051016,GO:0051490,GO:0070062,GO:0071203" cell morphogenesis|actin binding|protein binding|cytosol|cytoskeleton|endoplasmic reticulum to Golgi vesicle-mediated transport|cytoskeleton organization|blood coagulation|F-actin capping protein complex|regulation of lamellipodium assembly|actin cytoskeleton|antigen processing and presentation of exogenous peptide antigen via MHC class II|regulation of cell morphogenesis|sarcomere|actin cytoskeleton organization|cadherin binding|actin filament binding|barbed-end actin filament capping|negative regulation of filopodium assembly|extracellular exosome|WASH complex hsa04144 Endocytosis CARD10 673.3351363 682.511507 664.1587656 0.97310999 -0.039325214 0.884417614 1 8.86022494 8.477696352 29775 caspase recruitment domain family member 10 "GO:0005515,GO:0005737,GO:0007250,GO:0030159,GO:0032449,GO:0042981,GO:0050700,GO:0065003,GO:0090051,GO:1900182" protein binding|cytoplasm|activation of NF-kappaB-inducing kinase activity|signaling receptor complex adaptor activity|CBM complex|regulation of apoptotic process|CARD domain binding|protein-containing complex assembly|negative regulation of cell migration involved in sprouting angiogenesis|positive regulation of protein localization to nucleus hsa04064 NF-kappa B signaling pathway CARD11 1869.398261 1714.602079 2024.194443 1.180562224 0.239474084 0.312286377 1 21.04534536 24.42958661 84433 caspase recruitment domain family member 11 "GO:0001772,GO:0002223,GO:0004385,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007249,GO:0030183,GO:0030890,GO:0031295,GO:0032449,GO:0032743,GO:0038095,GO:0038202,GO:0042100,GO:0042102,GO:0042981,GO:0043123,GO:0045061,GO:0045121,GO:0045577,GO:0045580,GO:0046037,GO:0046710,GO:0048872,GO:0050700,GO:0050852,GO:0050862,GO:0051092,GO:0070062" immunological synapse|stimulatory C-type lectin receptor signaling pathway|guanylate kinase activity|protein binding|cytoplasm|cytosol|plasma membrane|I-kappaB kinase/NF-kappaB signaling|B cell differentiation|positive regulation of B cell proliferation|T cell costimulation|CBM complex|positive regulation of interleukin-2 production|Fc-epsilon receptor signaling pathway|TORC1 signaling|B cell proliferation|positive regulation of T cell proliferation|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|thymic T cell selection|membrane raft|regulation of B cell differentiation|regulation of T cell differentiation|GMP metabolic process|GDP metabolic process|homeostasis of number of cells|CARD domain binding|T cell receptor signaling pathway|positive regulation of T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|extracellular exosome "hsa04064,hsa04660,hsa04662" NF-kappa B signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway CARD14 8.888177384 6.242483296 11.53387147 1.847641543 0.88568489 0.505027526 1 0.061117201 0.111033071 79092 caspase recruitment domain family member 14 "GO:0001934,GO:0005737,GO:0005829,GO:0005886,GO:0006915,GO:0007250,GO:0016235,GO:0033209,GO:0043066,GO:0050700,GO:0051092" positive regulation of protein phosphorylation|cytoplasm|cytosol|plasma membrane|apoptotic process|activation of NF-kappaB-inducing kinase activity|aggresome|tumor necrosis factor-mediated signaling pathway|negative regulation of apoptotic process|CARD domain binding|positive regulation of NF-kappaB transcription factor activity hsa04064 NF-kappa B signaling pathway CARD16 25.09888091 28.09117483 22.10658699 0.786958435 -0.345640656 0.690755514 1 0.728461794 0.56367627 114769 caspase recruitment domain family member 16 "GO:0004869,GO:0005515,GO:0010804,GO:0019900,GO:0031665,GO:0032091,GO:0032691,GO:0032991,GO:0042802,GO:0043123,GO:0043154,GO:0050700,GO:0051092,GO:0071222,GO:0071456,GO:0071494,GO:0089720,GO:0097179,GO:0097340" cysteine-type endopeptidase inhibitor activity|protein binding|negative regulation of tumor necrosis factor-mediated signaling pathway|kinase binding|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of protein binding|negative regulation of interleukin-1 beta production|protein-containing complex|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|CARD domain binding|positive regulation of NF-kappaB transcription factor activity|cellular response to lipopolysaccharide|cellular response to hypoxia|cellular response to UV-C|caspase binding|protease inhibitor complex|inhibition of cysteine-type endopeptidase activity hsa04621 NOD-like receptor signaling pathway CARD19 660.786003 618.0058463 703.5661598 1.1384458 0.187065608 0.471385909 1 38.48522307 43.08018363 84270 caspase recruitment domain family member 19 "GO:0005634,GO:0005739,GO:0005789,GO:0005829,GO:0016021,GO:0031966,GO:0043124,GO:0050700" nucleus|mitochondrion|endoplasmic reticulum membrane|cytosol|integral component of membrane|mitochondrial membrane|negative regulation of I-kappaB kinase/NF-kappaB signaling|CARD domain binding CARD6 173.1703896 193.5169822 152.823797 0.789717756 -0.340590966 0.378383803 1 2.388447195 1.854636171 84674 caspase recruitment domain family member 6 "GO:0005515,GO:0006915,GO:0042981" protein binding|apoptotic process|regulation of apoptotic process hsa04621 NOD-like receptor signaling pathway CARD8 510.1625351 524.3685969 495.9564733 0.945816504 -0.080367778 0.773562731 1 3.329516748 3.096415769 22900 caspase recruitment domain family member 8 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0006919,GO:0008656,GO:0010804,GO:0031665,GO:0032088,GO:0032089,GO:0032691,GO:0032731,GO:0032991,GO:0042803,GO:0042981,GO:0043122,GO:0043124,GO:0043280,GO:0050700,GO:0061702,GO:0072559,GO:0097340" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cysteine-type endopeptidase activator activity involved in apoptotic process|negative regulation of tumor necrosis factor-mediated signaling pathway|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|NACHT domain binding|negative regulation of interleukin-1 beta production|positive regulation of interleukin-1 beta production|protein-containing complex|protein homodimerization activity|regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|CARD domain binding|inflammasome complex|NLRP3 inflammasome complex|inhibition of cysteine-type endopeptidase activity hsa04621 NOD-like receptor signaling pathway CARD9 9.086322201 11.44455271 6.728091692 0.587885946 -0.766391806 0.566347083 1 0.28932958 0.167246521 64170 caspase recruitment domain family member 9 "GO:0002223,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007249,GO:0009620,GO:0032494,GO:0032495,GO:0032663,GO:0032755,GO:0032760,GO:0032874,GO:0032991,GO:0042493,GO:0042803,GO:0042981,GO:0043123,GO:0043280,GO:0043330,GO:0045087,GO:0046330,GO:0050700,GO:0050830,GO:0051607" stimulatory C-type lectin receptor signaling pathway|protein binding|cytoplasm|cytosol|plasma membrane|I-kappaB kinase/NF-kappaB signaling|response to fungus|response to peptidoglycan|response to muramyl dipeptide|regulation of interleukin-2 production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of stress-activated MAPK cascade|protein-containing complex|response to drug|protein homodimerization activity|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|response to exogenous dsRNA|innate immune response|positive regulation of JNK cascade|CARD domain binding|defense response to Gram-positive bacterium|defense response to virus "hsa04621,hsa04625,hsa05152,hsa05168" NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Tuberculosis|Herpes simplex virus 1 infection CARF 128.0954393 145.6579436 110.5329349 0.758852777 -0.398108076 0.356947733 1 1.138640214 0.849601409 79800 calcium responsive transcription factor "GO:0000978,GO:0000981,GO:0001228,GO:0001652,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0035865,GO:0051090,GO:0061400,GO:0071277" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|granular component|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|cellular response to potassium ion|regulation of DNA-binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter in response to calcium ion|cellular response to calcium ion" CARHSP1 1597.744599 1433.69033 1761.798867 1.228855932 0.297315788 0.211664137 1 20.87109054 25.21838618 23589 calcium regulated heat stable protein 1 "GO:0000177,GO:0000932,GO:0003730,GO:0005515,GO:0005737,GO:0005829,GO:0019902,GO:0035556,GO:0043186,GO:0043488" cytoplasmic exosome (RNase complex)|P-body|mRNA 3'-UTR binding|protein binding|cytoplasm|cytosol|phosphatase binding|intracellular signal transduction|P granule|regulation of mRNA stability CARM1 1357.787733 1404.558742 1311.016724 0.933401135 -0.099430873 0.680530412 1 20.22085745 18.5583376 10498 coactivator associated arginine methyltransferase 1 "GO:0000976,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006977,GO:0007568,GO:0008013,GO:0008276,GO:0008284,GO:0008469,GO:0016032,GO:0016274,GO:0016571,GO:0019216,GO:0019919,GO:0030374,GO:0033146,GO:0034970,GO:0034971,GO:0035242,GO:0035642,GO:0042054,GO:0045600,GO:0045893,GO:0051591,GO:0070577,GO:1902415,GO:2000171" "transcription regulatory region sequence-specific DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|aging|beta-catenin binding|protein methyltransferase activity|positive regulation of cell population proliferation|histone-arginine N-methyltransferase activity|viral process|protein-arginine N-methyltransferase activity|histone methylation|regulation of lipid metabolic process|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|nuclear receptor coactivator activity|regulation of intracellular estrogen receptor signaling pathway|histone H3-R2 methylation|histone H3-R17 methylation|protein-arginine omega-N asymmetric methyltransferase activity|histone methyltransferase activity (H3-R17 specific)|histone methyltransferase activity|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-templated|response to cAMP|lysine-acetylated histone binding|regulation of mRNA binding|negative regulation of dendrite development" hsa01522 Endocrine resistance other CARMIL1 437.7789283 466.1054194 409.4524373 0.878454573 -0.186960412 0.511099626 1 3.262747845 2.818214195 55604 capping protein regulator and myosin 1 linker 1 "GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0007015,GO:0007596,GO:0016477,GO:0016607,GO:0030027,GO:0030032,GO:0030335,GO:0030838,GO:0031252,GO:0031529,GO:0031941,GO:0044351,GO:0044354,GO:0044877,GO:0046415,GO:0051496,GO:0051638,GO:0051639,GO:0070062,GO:1900026,GO:1902745,GO:2000813" protein binding|nucleoplasm|cytosol|plasma membrane|actin filament organization|blood coagulation|cell migration|nuclear speck|lamellipodium|lamellipodium assembly|positive regulation of cell migration|positive regulation of actin filament polymerization|cell leading edge|ruffle organization|filamentous actin|macropinocytosis|macropinosome|protein-containing complex binding|urate metabolic process|positive regulation of stress fiber assembly|barbed-end actin filament uncapping|actin filament network formation|extracellular exosome|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of lamellipodium organization|negative regulation of barbed-end actin filament capping CARMIL2 173.5025125 164.3853935 182.6196316 1.110923713 0.15175975 0.703375677 1 1.94435867 2.123888907 146206 capping protein regulator and myosin 1 linker 2 "GO:0001726,GO:0005543,GO:0005737,GO:0005886,GO:0007163,GO:0010592,GO:0015629,GO:0016020,GO:0030011,GO:0030027,GO:0030335,GO:0031234,GO:0031252,GO:0044319,GO:0044354,GO:0044877,GO:0045111,GO:0051639,GO:0061339,GO:0090091,GO:1900029,GO:1902745,GO:2000813" "ruffle|phospholipid binding|cytoplasm|plasma membrane|establishment or maintenance of cell polarity|positive regulation of lamellipodium assembly|actin cytoskeleton|membrane|maintenance of cell polarity|lamellipodium|positive regulation of cell migration|extrinsic component of cytoplasmic side of plasma membrane|cell leading edge|wound healing, spreading of cells|macropinosome|protein-containing complex binding|intermediate filament cytoskeleton|actin filament network formation|establishment or maintenance of monopolar cell polarity|positive regulation of extracellular matrix disassembly|positive regulation of ruffle assembly|positive regulation of lamellipodium organization|negative regulation of barbed-end actin filament capping" CARMIL3 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.036298743 0.021981596 90668 capping protein regulator and myosin 1 linker 3 "GO:0005737,GO:0005886" cytoplasm|plasma membrane CARNMT1 379.3666815 421.3676225 337.3657406 0.800644669 -0.320765987 0.275120604 1 3.82637665 3.012303403 138199 carnosine N-methyltransferase 1 "GO:0005515,GO:0005634,GO:0005829,GO:0006548,GO:0008757,GO:0030735,GO:0032259,GO:0035498,GO:0042803" protein binding|nucleus|cytosol|histidine catabolic process|S-adenosylmethionine-dependent methyltransferase activity|carnosine N-methyltransferase activity|methylation|carnosine metabolic process|protein homodimerization activity hsa00340 Histidine metabolism CARNS1 11.33069624 7.282897178 15.3784953 2.111590335 1.078329968 0.33937474 1 0.057985206 0.120392117 57571 carnosine synthase 1 "GO:0005524,GO:0005575,GO:0005829,GO:0006548,GO:0016887,GO:0035499,GO:0046872,GO:0047730,GO:0102102" ATP binding|cellular_component|cytosol|histidine catabolic process|ATPase activity|carnosine biosynthetic process|metal ion binding|carnosine synthase activity|homocarnosine synthase activity "hsa00330,hsa00340,hsa00410" Arginine and proline metabolism|Histidine metabolism|beta-Alanine metabolism CARS1 2729.83306 3006.796121 2452.87 0.815775297 -0.293756274 0.214228498 1 46.62033199 37.39530595 833 cysteinyl-tRNA synthetase 1 "GO:0000049,GO:0004817,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006418,GO:0006423,GO:0042802,GO:0046872" tRNA binding|cysteine-tRNA ligase activity|protein binding|ATP binding|cytoplasm|cytosol|tRNA aminoacylation for protein translation|cysteinyl-tRNA aminoacylation|identical protein binding|metal ion binding hsa00970 Aminoacyl-tRNA biosynthesis CARS2 893.1857564 915.5642167 870.8072961 0.951115476 -0.072307583 0.774722622 1 11.94085521 11.16708596 79587 "cysteinyl-tRNA synthetase 2, mitochondrial" "GO:0004817,GO:0005524,GO:0005737,GO:0005759,GO:0006423,GO:0046872" cysteine-tRNA ligase activity|ATP binding|cytoplasm|mitochondrial matrix|cysteinyl-tRNA aminoacylation|metal ion binding hsa00970 Aminoacyl-tRNA biosynthesis CASC3 2106.096221 2377.345722 1834.84672 0.77180475 -0.373692172 0.114092988 1 32.35770768 24.55592921 22794 CASC3 exon junction complex subunit "GO:0000184,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006405,GO:0006406,GO:0006417,GO:0008298,GO:0010494,GO:0016607,GO:0019899,GO:0030425,GO:0031124,GO:0031625,GO:0031965,GO:0035145,GO:0042802,GO:0048471,GO:0071006" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|regulation of translation|intracellular mRNA localization|cytoplasmic stress granule|nuclear speck|enzyme binding|dendrite|mRNA 3'-end processing|ubiquitin protein ligase binding|nuclear membrane|exon-exon junction complex|identical protein binding|perinuclear region of cytoplasm|U2-type catalytic step 1 spliceosome" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway CASD1 308.212187 294.4371288 321.9872453 1.093568758 0.129043933 0.686420297 1 2.462555777 2.647910788 64921 CAS1 domain containing 1 "GO:0005975,GO:0030173,GO:0047186" carbohydrate metabolic process|integral component of Golgi membrane|N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity CASK 1615.069329 1573.105791 1657.032868 1.053351197 0.074986525 0.754557703 1 9.736027461 10.08384501 8573 calcium/calmodulin dependent serine protein kinase "GO:0001953,GO:0004385,GO:0004674,GO:0005515,GO:0005516,GO:0005524,GO:0005604,GO:0005652,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0005925,GO:0006468,GO:0007155,GO:0007269,GO:0010839,GO:0015629,GO:0016363,GO:0042734,GO:0046037,GO:0046710,GO:0060170,GO:0061045,GO:0090288,GO:0106310,GO:0106311" negative regulation of cell-matrix adhesion|guanylate kinase activity|protein serine/threonine kinase activity|protein binding|calmodulin binding|ATP binding|basement membrane|nuclear lamina|nucleolus|cytoplasm|cytosol|plasma membrane|cell-cell junction|focal adhesion|protein phosphorylation|cell adhesion|neurotransmitter secretion|negative regulation of keratinocyte proliferation|actin cytoskeleton|nuclear matrix|presynaptic membrane|GMP metabolic process|GDP metabolic process|ciliary membrane|negative regulation of wound healing|negative regulation of cellular response to growth factor stimulus|protein serine kinase activity|protein threonine kinase activity CASKIN1 14.85325794 11.44455271 18.26196316 1.595690424 0.674180785 0.513436683 1 0.10640675 0.166950989 57524 CASK interacting protein 1 "GO:0005515,GO:0005737,GO:0007165,GO:0016020,GO:0042802" protein binding|cytoplasm|signal transduction|membrane|identical protein binding CASKIN2 536.0294575 534.7727357 537.2861794 1.004700022 0.006764814 0.987845925 1 5.557904193 5.490585346 57513 CASK interacting protein 2 "GO:0003674,GO:0005737,GO:0008150,GO:0016020" molecular_function|cytoplasm|biological_process|membrane CASP1 519.417434 515.0048719 523.829996 1.017136001 0.024512595 0.93550558 1 11.3573816 11.3586946 834 caspase 1 "GO:0001666,GO:0004175,GO:0004197,GO:0005515,GO:0005576,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006508,GO:0006915,GO:0006919,GO:0007165,GO:0008656,GO:0010506,GO:0016540,GO:0019221,GO:0019900,GO:0032611,GO:0032730,GO:0032731,GO:0032991,GO:0033198,GO:0042802,GO:0042981,GO:0043123,GO:0043280,GO:0050700,GO:0050727,GO:0051882,GO:0060081,GO:0070269,GO:0071222,GO:0071260,GO:0071310,GO:0071345,GO:0071346,GO:0072557,GO:0072558,GO:0072559,GO:0097153,GO:0097169,GO:0097179,GO:0097190,GO:0097194,GO:0097199,GO:0097200,GO:0097300,GO:0140448,GO:1901998,GO:1903265" response to hypoxia|endopeptidase activity|cysteine-type endopeptidase activity|protein binding|extracellular region|cytoplasm|mitochondrion|cytosol|plasma membrane|proteolysis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|cysteine-type endopeptidase activator activity involved in apoptotic process|regulation of autophagy|protein autoprocessing|cytokine-mediated signaling pathway|kinase binding|interleukin-1 beta production|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-1 beta production|protein-containing complex|response to ATP|identical protein binding|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|CARD domain binding|regulation of inflammatory response|mitochondrial depolarization|membrane hyperpolarization|pyroptosis|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|cellular response to organic substance|cellular response to cytokine stimulus|cellular response to interferon-gamma|IPAF inflammasome complex|NLRP1 inflammasome complex|NLRP3 inflammasome complex|cysteine-type endopeptidase activity involved in apoptotic process|AIM2 inflammasome complex|protease inhibitor complex|apoptotic signaling pathway|execution phase of apoptosis|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|cysteine-type endopeptidase activity involved in execution phase of apoptosis|programmed necrotic cell death|signaling receptor ligand precursor processing|toxin transport|positive regulation of tumor necrosis factor-mediated signaling pathway "hsa04217,hsa04621,hsa04623,hsa04625,hsa05014,hsa05130,hsa05131,hsa05132,hsa05133,hsa05134,hsa05135,hsa05164,hsa05171" Necroptosis|NOD-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|Amyotrophic lateral sclerosis|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Influenza A|Coronavirus disease - COVID-19 CASP10 354.3219064 457.7821084 250.8617045 0.547993685 -0.867768827 0.003817929 0.381096168 3.654598318 1.969184381 843 caspase 10 "GO:0004197,GO:0005515,GO:0005737,GO:0005829,GO:0006508,GO:0006915,GO:0006919,GO:0007166,GO:0031265,GO:0031625,GO:0035877,GO:0042981,GO:0043123,GO:0097153,GO:0097190,GO:0097194,GO:0097199,GO:0097200,GO:0097342" cysteine-type endopeptidase activity|protein binding|cytoplasm|cytosol|proteolysis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell surface receptor signaling pathway|CD95 death-inducing signaling complex|ubiquitin protein ligase binding|death effector domain binding|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|cysteine-type endopeptidase activity involved in apoptotic process|apoptotic signaling pathway|execution phase of apoptosis|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|cysteine-type endopeptidase activity involved in execution phase of apoptosis|ripoptosome "hsa04210,hsa04622,hsa04668,hsa05152,hsa05161" Apoptosis|RIG-I-like receptor signaling pathway|TNF signaling pathway|Tuberculosis|Hepatitis B CASP2 938.7312239 988.3931885 889.0692593 0.899509699 -0.152789258 0.538442747 1 12.50266127 11.05807405 835 caspase 2 "GO:0001554,GO:0003407,GO:0004197,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006915,GO:0006919,GO:0006977,GO:0007420,GO:0007568,GO:0008630,GO:0016020,GO:0016485,GO:0019899,GO:0019904,GO:0035234,GO:0042802,GO:0042981,GO:0043065,GO:0043066,GO:0043525,GO:0071260,GO:0097153,GO:0097190,GO:0097192,GO:0097194,GO:0097199,GO:0097200,GO:2001235" "luteolysis|neural retina development|cysteine-type endopeptidase activity|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|brain development|aging|intrinsic apoptotic signaling pathway in response to DNA damage|membrane|protein processing|enzyme binding|protein domain specific binding|ectopic germ cell programmed cell death|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of neuron apoptotic process|cellular response to mechanical stimulus|cysteine-type endopeptidase activity involved in apoptotic process|apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|execution phase of apoptosis|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|cysteine-type endopeptidase activity involved in execution phase of apoptosis|positive regulation of apoptotic signaling pathway" hsa04210 Apoptosis CASP3 1214.730824 1118.444924 1311.016724 1.17217817 0.229191875 0.343907288 1 21.03960168 24.24947392 836 caspase 3 "GO:0001554,GO:0001666,GO:0001782,GO:0002020,GO:0004190,GO:0004197,GO:0004861,GO:0005123,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006309,GO:0006508,GO:0006915,GO:0006974,GO:0007413,GO:0007507,GO:0007605,GO:0007611,GO:0008233,GO:0008627,GO:0009411,GO:0009749,GO:0010165,GO:0016005,GO:0016241,GO:0016485,GO:0019221,GO:0021766,GO:0030182,GO:0030216,GO:0030218,GO:0030220,GO:0030889,GO:0031264,GO:0031647,GO:0032025,GO:0032355,GO:0032496,GO:0034349,GO:0034612,GO:0035094,GO:0035329,GO:0042060,GO:0042493,GO:0042542,GO:0043025,GO:0043029,GO:0043065,GO:0043066,GO:0043200,GO:0043525,GO:0044877,GO:0045121,GO:0045165,GO:0045736,GO:0046007,GO:0046677,GO:0048011,GO:0051146,GO:0051384,GO:0051402,GO:0061713,GO:0071887,GO:0072734,GO:0097153,GO:0097190,GO:0097192,GO:0097194,GO:0097199,GO:0097200,GO:1902004" luteolysis|response to hypoxia|B cell homeostasis|protease binding|aspartic-type endopeptidase activity|cysteine-type endopeptidase activity|cyclin-dependent protein serine/threonine kinase inhibitor activity|death receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|apoptotic DNA fragmentation|proteolysis|apoptotic process|cellular response to DNA damage stimulus|axonal fasciculation|heart development|sensory perception of sound|learning or memory|peptidase activity|intrinsic apoptotic signaling pathway in response to osmotic stress|response to UV|response to glucose|response to X-ray|phospholipase A2 activator activity|regulation of macroautophagy|protein processing|cytokine-mediated signaling pathway|hippocampus development|neuron differentiation|keratinocyte differentiation|erythrocyte differentiation|platelet formation|negative regulation of B cell proliferation|death-inducing signaling complex|regulation of protein stability|response to cobalt ion|response to estradiol|response to lipopolysaccharide|glial cell apoptotic process|response to tumor necrosis factor|response to nicotine|hippo signaling|wound healing|response to drug|response to hydrogen peroxide|neuronal cell body|T cell homeostasis|positive regulation of apoptotic process|negative regulation of apoptotic process|response to amino acid|positive regulation of neuron apoptotic process|protein-containing complex binding|membrane raft|cell fate commitment|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of activated T cell proliferation|response to antibiotic|neurotrophin TRK receptor signaling pathway|striated muscle cell differentiation|response to glucocorticoid|neuron apoptotic process|anterior neural tube closure|leukocyte apoptotic process|cellular response to staurosporine|cysteine-type endopeptidase activity involved in apoptotic process|apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|execution phase of apoptosis|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|cysteine-type endopeptidase activity involved in execution phase of apoptosis|positive regulation of amyloid-beta formation "hsa01524,hsa04010,hsa04115,hsa04210,hsa04215,hsa04650,hsa04657,hsa04668,hsa04726,hsa04932,hsa04933,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05120,hsa05130,hsa05132,hsa05133,hsa05134,hsa05145,hsa05146,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05222,hsa05416" Platinum drug resistance|MAPK signaling pathway|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Natural killer cell mediated cytotoxicity|IL-17 signaling pathway|TNF signaling pathway|Serotonergic synapse|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Salmonella infection|Pertussis|Legionellosis|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Small cell lung cancer|Viral myocarditis CASP4 3364.110474 3219.040553 3509.180395 1.090132397 0.124503362 0.600118869 1 124.8504927 133.8260581 837 caspase 4 "GO:0004197,GO:0005515,GO:0005576,GO:0005737,GO:0005739,GO:0005783,GO:0005789,GO:0005829,GO:0005886,GO:0006508,GO:0006915,GO:0006919,GO:0006954,GO:0016540,GO:0032991,GO:0042981,GO:0045087,GO:0050700,GO:0050727,GO:0070059,GO:0070269,GO:0072557,GO:0072559,GO:0097153,GO:0097169,GO:0097193,GO:0097194,GO:0097199,GO:0097200,GO:1903265,GO:1904646" cysteine-type endopeptidase activity|protein binding|extracellular region|cytoplasm|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|plasma membrane|proteolysis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|protein autoprocessing|protein-containing complex|regulation of apoptotic process|innate immune response|CARD domain binding|regulation of inflammatory response|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|pyroptosis|IPAF inflammasome complex|NLRP3 inflammasome complex|cysteine-type endopeptidase activity involved in apoptotic process|AIM2 inflammasome complex|intrinsic apoptotic signaling pathway|execution phase of apoptosis|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|cysteine-type endopeptidase activity involved in execution phase of apoptosis|positive regulation of tumor necrosis factor-mediated signaling pathway|cellular response to amyloid-beta "hsa04621,hsa05130,hsa05131,hsa05132" NOD-like receptor signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection CASP6 345.241229 332.9324424 357.5500156 1.073941647 0.102915606 0.740371833 1 10.87392445 11.48254548 839 caspase 6 "GO:0004197,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006508,GO:0006915,GO:0008234,GO:0030855,GO:0042802,GO:0042981,GO:0072734,GO:0097153,GO:0097194,GO:0097200" cysteine-type endopeptidase activity|protein binding|nucleoplasm|cytoplasm|cytosol|proteolysis|apoptotic process|cysteine-type peptidase activity|epithelial cell differentiation|identical protein binding|regulation of apoptotic process|cellular response to staurosporine|cysteine-type endopeptidase activity involved in apoptotic process|execution phase of apoptosis|cysteine-type endopeptidase activity involved in execution phase of apoptosis hsa04210 Apoptosis CASP7 203.3178545 215.3656737 191.2700352 0.888117554 -0.171177447 0.643881733 1 2.991585159 2.612420016 840 caspase 7 "GO:0004197,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006508,GO:0006915,GO:0008233,GO:0008234,GO:0072734,GO:0097153,GO:0097194,GO:0097200" cysteine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteolysis|apoptotic process|peptidase activity|cysteine-type peptidase activity|cellular response to staurosporine|cysteine-type endopeptidase activity involved in apoptotic process|execution phase of apoptosis|cysteine-type endopeptidase activity involved in execution phase of apoptosis "hsa04210,hsa04215,hsa04668,hsa04932,hsa05010,hsa05022,hsa05130,hsa05132,hsa05133,hsa05134,hsa05200" Apoptosis|Apoptosis - multiple species|TNF signaling pathway|Non-alcoholic fatty liver disease|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection|Pertussis|Legionellosis|Pathways in cancer CASP8 1000.467888 1032.090572 968.8452036 0.938721107 -0.091231497 0.713372958 1 18.29926143 16.890454 841 caspase 8 "GO:0001525,GO:0004197,GO:0005123,GO:0005164,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005829,GO:0005856,GO:0006508,GO:0006915,GO:0006919,GO:0007166,GO:0007507,GO:0008233,GO:0008234,GO:0008625,GO:0009409,GO:0010803,GO:0030101,GO:0030225,GO:0031264,GO:0031265,GO:0031625,GO:0032025,GO:0032355,GO:0032496,GO:0032731,GO:0032991,GO:0034138,GO:0034612,GO:0035666,GO:0035877,GO:0036462,GO:0039650,GO:0042110,GO:0042113,GO:0042802,GO:0043005,GO:0043065,GO:0043123,GO:0043124,GO:0044297,GO:0044877,GO:0045121,GO:0045471,GO:0045651,GO:0045862,GO:0046677,GO:0051603,GO:0060544,GO:0060546,GO:0060715,GO:0070269,GO:0070423,GO:0071260,GO:0071407,GO:0071550,GO:0097110,GO:0097153,GO:0097190,GO:0097191,GO:0097194,GO:0097199,GO:0097200,GO:0097202,GO:0097264,GO:0097296,GO:0097342,GO:1900740,GO:1901216,GO:1902041,GO:1902042" angiogenesis|cysteine-type endopeptidase activity|death receptor binding|tumor necrosis factor receptor binding|protein binding|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|cytosol|cytoskeleton|proteolysis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell surface receptor signaling pathway|heart development|peptidase activity|cysteine-type peptidase activity|extrinsic apoptotic signaling pathway via death domain receptors|response to cold|regulation of tumor necrosis factor-mediated signaling pathway|natural killer cell activation|macrophage differentiation|death-inducing signaling complex|CD95 death-inducing signaling complex|ubiquitin protein ligase binding|response to cobalt ion|response to estradiol|response to lipopolysaccharide|positive regulation of interleukin-1 beta production|protein-containing complex|toll-like receptor 3 signaling pathway|response to tumor necrosis factor|TRIF-dependent toll-like receptor signaling pathway|death effector domain binding|TRAIL-activated apoptotic signaling pathway|suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process|T cell activation|B cell activation|identical protein binding|neuron projection|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|cell body|protein-containing complex binding|membrane raft|response to ethanol|positive regulation of macrophage differentiation|positive regulation of proteolysis|response to antibiotic|proteolysis involved in cellular protein catabolic process|regulation of necroptotic process|negative regulation of necroptotic process|syncytiotrophoblast cell differentiation involved in labyrinthine layer development|pyroptosis|nucleotide-binding oligomerization domain containing signaling pathway|cellular response to mechanical stimulus|cellular response to organic cyclic compound|death-inducing signaling complex assembly|scaffold protein binding|cysteine-type endopeptidase activity involved in apoptotic process|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|execution phase of apoptosis|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|cysteine-type endopeptidase activity involved in execution phase of apoptosis|activation of cysteine-type endopeptidase activity|self proteolysis|activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|ripoptosome|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of neuron death|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors "hsa01524,hsa04115,hsa04210,hsa04215,hsa04217,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04668,hsa04932,hsa05010,hsa05016,hsa05022,hsa05130,hsa05132,hsa05134,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05203,hsa05416" Platinum drug resistance|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Necroptosis|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Non-alcoholic fatty liver disease|Alzheimer disease|Huntington disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection|Legionellosis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Viral myocarditis CASP8AP2 621.9875202 697.0773014 546.897739 0.784558237 -0.350047553 0.180194703 1 5.627247678 4.341026089 9994 caspase 8 associated protein 2 "GO:0003714,GO:0005123,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0006919,GO:0007049,GO:0007165,GO:0008625,GO:0008656,GO:0016505,GO:0016605,GO:0032184,GO:0036337,GO:0045892,GO:0071260,GO:0097190" "transcription corepressor activity|death receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell cycle|signal transduction|extrinsic apoptotic signaling pathway via death domain receptors|cysteine-type endopeptidase activator activity involved in apoptotic process|peptidase activator activity involved in apoptotic process|PML body|SUMO polymer binding|Fas signaling pathway|negative regulation of transcription, DNA-templated|cellular response to mechanical stimulus|apoptotic signaling pathway" other CASP9 180.3343999 204.9615349 155.7072649 0.759690178 -0.396516926 0.295994868 1 2.776953646 2.074322702 842 caspase 9 "GO:0004197,GO:0005515,GO:0005737,GO:0005829,GO:0006508,GO:0006915,GO:0006919,GO:0006974,GO:0008047,GO:0008233,GO:0008630,GO:0008635,GO:0017124,GO:0019901,GO:0030220,GO:0032991,GO:0034644,GO:0042770,GO:0043065,GO:0043293,GO:0097153,GO:0097192,GO:0097194,GO:0097199,GO:0097200,GO:2001020" cysteine-type endopeptidase activity|protein binding|cytoplasm|cytosol|proteolysis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to DNA damage stimulus|enzyme activator activity|peptidase activity|intrinsic apoptotic signaling pathway in response to DNA damage|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|SH3 domain binding|protein kinase binding|platelet formation|protein-containing complex|cellular response to UV|signal transduction in response to DNA damage|positive regulation of apoptotic process|apoptosome|cysteine-type endopeptidase activity involved in apoptotic process|extrinsic apoptotic signaling pathway in absence of ligand|execution phase of apoptosis|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|cysteine-type endopeptidase activity involved in execution phase of apoptosis|regulation of response to DNA damage stimulus "hsa01524,hsa04115,hsa04151,hsa04210,hsa04215,hsa04370,hsa04919,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05134,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05210,hsa05212,hsa05213,hsa05215,hsa05222,hsa05223,hsa05416" Platinum drug resistance|p53 signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Apoptosis - multiple species|VEGF signaling pathway|Thyroid hormone signaling pathway|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Legionellosis|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Prostate cancer|Small cell lung cancer|Non-small cell lung cancer|Viral myocarditis CAST 5542.461968 5575.577997 5509.34594 0.988121042 -0.017240316 0.943781039 1 61.08773357 59.35199737 831 calpastatin "GO:0003723,GO:0004866,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0010859,GO:0016020,GO:0045296,GO:0097340,GO:1990709,GO:2000675" RNA binding|endopeptidase inhibitor activity|protein binding|cytoplasm|endoplasmic reticulum|cytosol|calcium-dependent cysteine-type endopeptidase inhibitor activity|membrane|cadherin binding|inhibition of cysteine-type endopeptidase activity|presynaptic active zone organization|negative regulation of type B pancreatic cell apoptotic process hsa05131 Shigellosis CASTOR1 137.5535134 129.0113214 146.0957053 1.132425462 0.179416093 0.680091238 1 4.587006737 5.107521252 652968 cytosolic arginine sensor for mTORC1 subunit 1 "GO:0005515,GO:0005829,GO:0034618,GO:0042802,GO:0061700,GO:1902531,GO:1903577,GO:1904262" protein binding|cytosol|arginine binding|identical protein binding|GATOR2 complex|regulation of intracellular signal transduction|cellular response to L-arginine|negative regulation of TORC1 signaling hsa04150 mTOR signaling pathway CASTOR2 233.084121 189.3553266 276.8129153 1.461870232 0.547815251 0.110772424 1 1.245292146 1.789992661 729438 cytosolic arginine sensor for mTORC1 subunit 2 "GO:0005515,GO:0005829,GO:0034618,GO:0042802,GO:0061700,GO:1902531,GO:1903577,GO:1904262" protein binding|cytosol|arginine binding|identical protein binding|GATOR2 complex|regulation of intracellular signal transduction|cellular response to L-arginine|negative regulation of TORC1 signaling hsa04150 mTOR signaling pathway CASZ1 24.25661184 31.21241648 17.30080721 0.554292463 -0.851280704 0.286291334 1 0.181870215 0.099122383 54897 castor zinc finger 1 "GO:0000785,GO:0000977,GO:0001228,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0007275,GO:0043231,GO:0045664,GO:0045893,GO:0045944,GO:0046872" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|multicellular organism development|intracellular membrane-bounded organelle|regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding" other CAT 1354.285907 1249.537073 1459.034741 1.167660226 0.22362053 0.351951106 1 29.10759364 33.41903991 847 catalase "GO:0000268,GO:0000302,GO:0001649,GO:0001657,GO:0001666,GO:0004046,GO:0004096,GO:0005576,GO:0005737,GO:0005739,GO:0005758,GO:0005764,GO:0005777,GO:0005778,GO:0005782,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0005925,GO:0006625,GO:0006641,GO:0007568,GO:0008203,GO:0009060,GO:0009642,GO:0009650,GO:0010193,GO:0010288,GO:0014068,GO:0014823,GO:0014854,GO:0016020,GO:0016209,GO:0016684,GO:0019899,GO:0020027,GO:0020037,GO:0032088,GO:0032355,GO:0032868,GO:0032991,GO:0033189,GO:0033197,GO:0033591,GO:0034599,GO:0034774,GO:0042493,GO:0042542,GO:0042744,GO:0042802,GO:0042803,GO:0043066,GO:0043231,GO:0043312,GO:0045471,GO:0046686,GO:0046872,GO:0050661,GO:0051092,GO:0051781,GO:0055093,GO:0070062,GO:0070542,GO:0071363,GO:0080184,GO:0098869,GO:1904813" "peroxisome targeting sequence binding|response to reactive oxygen species|osteoblast differentiation|ureteric bud development|response to hypoxia|aminoacylase activity|catalase activity|extracellular region|cytoplasm|mitochondrion|mitochondrial intermembrane space|lysosome|peroxisome|peroxisomal membrane|peroxisomal matrix|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|focal adhesion|protein targeting to peroxisome|triglyceride metabolic process|aging|cholesterol metabolic process|aerobic respiration|response to light intensity|UV protection|response to ozone|response to lead ion|positive regulation of phosphatidylinositol 3-kinase signaling|response to activity|response to inactivity|membrane|antioxidant activity|oxidoreductase activity, acting on peroxide as acceptor|enzyme binding|hemoglobin metabolic process|heme binding|negative regulation of NF-kappaB transcription factor activity|response to estradiol|response to insulin|protein-containing complex|response to vitamin A|response to vitamin E|response to L-ascorbic acid|cellular response to oxidative stress|secretory granule lumen|response to drug|response to hydrogen peroxide|hydrogen peroxide catabolic process|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|intracellular membrane-bounded organelle|neutrophil degranulation|response to ethanol|response to cadmium ion|metal ion binding|NADP binding|positive regulation of NF-kappaB transcription factor activity|positive regulation of cell division|response to hyperoxia|extracellular exosome|response to fatty acid|cellular response to growth factor stimulus|response to phenylpropanoid|cellular oxidant detoxification|ficolin-1-rich granule lumen" "hsa00380,hsa00630,hsa04068,hsa04146,hsa04211,hsa04213,hsa05014,hsa05022" Tryptophan metabolism|Glyoxylate and dicarboxylate metabolism|FoxO signaling pathway|Peroxisome|Longevity regulating pathway|Longevity regulating pathway - multiple species|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases CATSPER1 472.3258225 502.5199053 442.1317398 0.879829306 -0.184704438 0.507941508 1 10.39076472 8.98911867 117144 cation channel sperm associated 1 "GO:0005227,GO:0005245,GO:0005515,GO:0005886,GO:0006816,GO:0007275,GO:0007283,GO:0030154,GO:0030317,GO:0031514,GO:0032570,GO:0034765,GO:0035036,GO:0036128,GO:0060296,GO:0070588" calcium activated cation channel activity|voltage-gated calcium channel activity|protein binding|plasma membrane|calcium ion transport|multicellular organism development|spermatogenesis|cell differentiation|flagellated sperm motility|motile cilium|response to progesterone|regulation of ion transmembrane transport|sperm-egg recognition|CatSper complex|regulation of cilium beat frequency involved in ciliary motility|calcium ion transmembrane transport CATSPER2 71.81370999 81.15228285 62.47513714 0.769850643 -0.377349516 0.482331486 1 1.070427134 0.810279338 117155 cation channel sperm associated 2 "GO:0005227,GO:0005244,GO:0005262,GO:0005515,GO:0005886,GO:0007275,GO:0009566,GO:0030317,GO:0031514,GO:0032570,GO:0034765,GO:0035036,GO:0036128,GO:0048240,GO:0070588" calcium activated cation channel activity|voltage-gated ion channel activity|calcium channel activity|protein binding|plasma membrane|multicellular organism development|fertilization|flagellated sperm motility|motile cilium|response to progesterone|regulation of ion transmembrane transport|sperm-egg recognition|CatSper complex|sperm capacitation|calcium ion transmembrane transport CATSPER3 5.643018428 9.363724944 1.922311912 0.205293505 -2.284240111 0.166157707 1 0.368800583 0.07444542 347732 cation channel sperm associated 3 "GO:0001669,GO:0005245,GO:0005783,GO:0005886,GO:0006814,GO:0007275,GO:0030317,GO:0031514,GO:0032570,GO:0034765,GO:0035036,GO:0036128,GO:0048240,GO:0070588" acrosomal vesicle|voltage-gated calcium channel activity|endoplasmic reticulum|plasma membrane|sodium ion transport|multicellular organism development|flagellated sperm motility|motile cilium|response to progesterone|regulation of ion transmembrane transport|sperm-egg recognition|CatSper complex|sperm capacitation|calcium ion transmembrane transport CATSPERE 9.606529142 12.48496659 6.728091692 0.53889545 -0.891922689 0.47680615 1 0.126360652 0.0669557 257044 catsper channel auxiliary subunit epsilon "GO:0036128,GO:0097228" CatSper complex|sperm principal piece CATSPERG 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.045130027 0.054659195 57828 cation channel sperm associated auxiliary subunit gamma "GO:0005886,GO:0007275,GO:0007283,GO:0030154,GO:0031514,GO:0032570,GO:0035036,GO:0036128,GO:0097228" plasma membrane|multicellular organism development|spermatogenesis|cell differentiation|motile cilium|response to progesterone|sperm-egg recognition|CatSper complex|sperm principal piece CATSPERZ 7.005494435 7.282897178 6.728091692 0.923820772 -0.11431511 1 1 0.498301073 0.452637701 25858 catsper channel auxiliary subunit zeta "GO:0005737,GO:0007140,GO:0007283,GO:0030317,GO:0036128,GO:0048240,GO:0097228" cytoplasm|male meiotic nuclear division|spermatogenesis|flagellated sperm motility|CatSper complex|sperm capacitation|sperm principal piece CAV1 6050.652502 6123.876113 5977.42889 0.976085861 -0.034920035 0.886007355 1 101.4024241 97.32121853 857 caveolin 1 "GO:0000122,GO:0000139,GO:0000188,GO:0001525,GO:0001570,GO:0001666,GO:0001937,GO:0001960,GO:0002080,GO:0002095,GO:0002931,GO:0003057,GO:0005102,GO:0005113,GO:0005515,GO:0005768,GO:0005783,GO:0005789,GO:0005794,GO:0005811,GO:0005886,GO:0005887,GO:0005901,GO:0005925,GO:0005929,GO:0005938,GO:0006641,GO:0006816,GO:0006874,GO:0006940,GO:0007519,GO:0007595,GO:0008104,GO:0009617,GO:0010524,GO:0010608,GO:0010628,GO:0010875,GO:0010952,GO:0015031,GO:0015485,GO:0016020,GO:0016050,GO:0016504,GO:0019065,GO:0019217,GO:0019899,GO:0019901,GO:0019915,GO:0030154,GO:0030193,GO:0030301,GO:0030335,GO:0030512,GO:0030666,GO:0030674,GO:0030857,GO:0030879,GO:0031267,GO:0031295,GO:0031397,GO:0031398,GO:0031410,GO:0031623,GO:0031901,GO:0032091,GO:0032092,GO:0032507,GO:0032570,GO:0032991,GO:0033137,GO:0033138,GO:0033484,GO:0034141,GO:0038016,GO:0042310,GO:0042383,GO:0042532,GO:0042632,GO:0042802,GO:0043085,GO:0043409,GO:0043627,GO:0044325,GO:0044860,GO:0044877,GO:0045019,GO:0045121,GO:0045907,GO:0046426,GO:0046982,GO:0048471,GO:0048550,GO:0050900,GO:0050998,GO:0050999,GO:0051001,GO:0051092,GO:0051117,GO:0051480,GO:0051592,GO:0051899,GO:0052547,GO:0055074,GO:0060056,GO:0060090,GO:0060355,GO:0060546,GO:0061099,GO:0070320,GO:0070836,GO:0071360,GO:0071375,GO:0071455,GO:0071560,GO:0071711,GO:0072584,GO:0086091,GO:0086098,GO:0090090,GO:0090263,GO:0097190,GO:0098903,GO:0098909,GO:0098911,GO:0120162,GO:1900027,GO:1900085,GO:1901380,GO:1901844,GO:1903071,GO:1903361,GO:1903598,GO:1903609,GO:1904886,GO:2000286,GO:2000535,GO:2000811,GO:2001238,GO:2001244" negative regulation of transcription by RNA polymerase II|Golgi membrane|inactivation of MAPK activity|angiogenesis|vasculogenesis|response to hypoxia|negative regulation of endothelial cell proliferation|negative regulation of cytokine-mediated signaling pathway|acrosomal membrane|caveolar macromolecular signaling complex|response to ischemia|regulation of the force of heart contraction by chemical signal|signaling receptor binding|patched binding|protein binding|endosome|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|lipid droplet|plasma membrane|integral component of plasma membrane|caveola|focal adhesion|cilium|cell cortex|triglyceride metabolic process|calcium ion transport|cellular calcium ion homeostasis|regulation of smooth muscle contraction|skeletal muscle tissue development|lactation|protein localization|response to bacterium|positive regulation of calcium ion transport into cytosol|posttranscriptional regulation of gene expression|positive regulation of gene expression|positive regulation of cholesterol efflux|positive regulation of peptidase activity|protein transport|cholesterol binding|membrane|vesicle organization|peptidase activator activity|receptor-mediated endocytosis of virus by host cell|regulation of fatty acid metabolic process|enzyme binding|protein kinase binding|lipid storage|cell differentiation|regulation of blood coagulation|cholesterol transport|positive regulation of cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|endocytic vesicle membrane|protein-macromolecule adaptor activity|negative regulation of epithelial cell differentiation|mammary gland development|small GTPase binding|T cell costimulation|negative regulation of protein ubiquitination|positive regulation of protein ubiquitination|cytoplasmic vesicle|receptor internalization|early endosome membrane|negative regulation of protein binding|positive regulation of protein binding|maintenance of protein location in cell|response to progesterone|protein-containing complex|negative regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-serine phosphorylation|nitric oxide homeostasis|positive regulation of toll-like receptor 3 signaling pathway|insulin receptor internalization|vasoconstriction|sarcolemma|negative regulation of tyrosine phosphorylation of STAT protein|cholesterol homeostasis|identical protein binding|positive regulation of catalytic activity|negative regulation of MAPK cascade|response to estrogen|ion channel binding|protein localization to plasma membrane raft|protein-containing complex binding|negative regulation of nitric oxide biosynthetic process|membrane raft|positive regulation of vasoconstriction|negative regulation of receptor signaling pathway via JAK-STAT|protein heterodimerization activity|perinuclear region of cytoplasm|negative regulation of pinocytosis|leukocyte migration|nitric-oxide synthase binding|regulation of nitric-oxide synthase activity|negative regulation of nitric-oxide synthase activity|positive regulation of NF-kappaB transcription factor activity|ATPase binding|regulation of cytosolic calcium ion concentration|response to calcium ion|membrane depolarization|regulation of peptidase activity|calcium ion homeostasis|mammary gland involution|molecular adaptor activity|positive regulation of cell adhesion molecule production|negative regulation of necroptotic process|negative regulation of protein tyrosine kinase activity|inward rectifier potassium channel inhibitor activity|caveola assembly|cellular response to exogenous dsRNA|cellular response to peptide hormone stimulus|cellular response to hyperoxia|cellular response to transforming growth factor beta stimulus|basement membrane organization|caveolin-mediated endocytosis|regulation of heart rate by cardiac conduction|angiotensin-activated signaling pathway involved in heart process|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|apoptotic signaling pathway|regulation of membrane repolarization during action potential|regulation of cardiac muscle cell action potential involved in regulation of contraction|regulation of ventricular cardiac muscle cell action potential|positive regulation of cold-induced thermogenesis|regulation of ruffle assembly|negative regulation of peptidyl-tyrosine autophosphorylation|negative regulation of potassium ion transmembrane transport|regulation of cell communication by electrical coupling involved in cardiac conduction|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|protein localization to basolateral plasma membrane|positive regulation of gap junction assembly|negative regulation of inward rectifier potassium channel activity|beta-catenin destruction complex disassembly|receptor internalization involved in canonical Wnt signaling pathway|regulation of entry of bacterium into host cell|negative regulation of anoikis|positive regulation of extrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway "hsa04144,hsa04510,hsa05020,hsa05100,hsa05205,hsa05416,hsa05418" Endocytosis|Focal adhesion|Prion disease|Bacterial invasion of epithelial cells|Proteoglycans in cancer|Viral myocarditis|Fluid shear stress and atherosclerosis CAV2 2676.457992 2387.749861 2965.166124 1.241824436 0.312461226 0.18646608 1 40.23676084 49.13086288 858 caveolin 2 "GO:0000139,GO:0001937,GO:0001938,GO:0002080,GO:0002095,GO:0005515,GO:0005634,GO:0005794,GO:0005886,GO:0005887,GO:0005901,GO:0005925,GO:0006906,GO:0007005,GO:0007029,GO:0007088,GO:0008286,GO:0016050,GO:0019065,GO:0019901,GO:0030133,GO:0030154,GO:0030512,GO:0030674,GO:0031234,GO:0031410,GO:0032991,GO:0042383,GO:0042803,GO:0043410,GO:0043547,GO:0044791,GO:0044794,GO:0045121,GO:0046982,GO:0048278,GO:0048471,GO:0048741,GO:0051480,GO:0060090,GO:0060161,GO:0070836,GO:0071711,GO:0097110" Golgi membrane|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|acrosomal membrane|caveolar macromolecular signaling complex|protein binding|nucleus|Golgi apparatus|plasma membrane|integral component of plasma membrane|caveola|focal adhesion|vesicle fusion|mitochondrion organization|endoplasmic reticulum organization|regulation of mitotic nuclear division|insulin receptor signaling pathway|vesicle organization|receptor-mediated endocytosis of virus by host cell|protein kinase binding|transport vesicle|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway|protein-macromolecule adaptor activity|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic vesicle|protein-containing complex|sarcolemma|protein homodimerization activity|positive regulation of MAPK cascade|positive regulation of GTPase activity|positive regulation by host of viral release from host cell|positive regulation by host of viral process|membrane raft|protein heterodimerization activity|vesicle docking|perinuclear region of cytoplasm|skeletal muscle fiber development|regulation of cytosolic calcium ion concentration|molecular adaptor activity|positive regulation of dopamine receptor signaling pathway|caveola assembly|basement membrane organization|scaffold protein binding "hsa04144,hsa04510,hsa05020,hsa05100,hsa05205,hsa05418" Endocytosis|Focal adhesion|Prion disease|Bacterial invasion of epithelial cells|Proteoglycans in cancer|Fluid shear stress and atherosclerosis CAVIN1 8141.279565 7931.075027 8351.484102 1.05300783 0.074516164 0.763208951 1 94.7541745 98.10725656 284119 caveolae associated protein 1 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0005886,GO:0005901,GO:0006361,GO:0006363,GO:0009303,GO:0009306,GO:0032991,GO:0042134,GO:0042802,GO:0043231,GO:0045121,GO:2000147" RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|plasma membrane|caveola|transcription initiation from RNA polymerase I promoter|termination of RNA polymerase I transcription|rRNA transcription|protein secretion|protein-containing complex|rRNA primary transcript binding|identical protein binding|intracellular membrane-bounded organelle|membrane raft|positive regulation of cell motility CAVIN3 865.2788639 700.198543 1030.359185 1.47152432 0.557311386 0.025549301 0.86539048 36.35049546 52.59554472 112464 caveolae associated protein 3 "GO:0005080,GO:0005515,GO:0005737,GO:0005829,GO:0005901,GO:0032922,GO:0032991" protein kinase C binding|protein binding|cytoplasm|cytosol|caveola|circadian regulation of gene expression|protein-containing complex CAVIN4 57.48568942 58.26317743 56.7082014 0.97331117 -0.039026983 0.979599862 1 1.003679373 0.960545374 347273 caveolae associated protein 4 "GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005901,GO:0007517,GO:0010468,GO:0030018,GO:0030154,GO:0035023,GO:0042383,GO:0045944" protein binding|cytoplasm|cytosol|plasma membrane|caveola|muscle organ development|regulation of gene expression|Z disc|cell differentiation|regulation of Rho protein signal transduction|sarcolemma|positive regulation of transcription by RNA polymerase II CBARP 203.164369 198.7190516 207.6096865 1.044739721 0.063143564 0.874646844 1 2.28364999 2.345896389 255057 CACN subunit beta associated regulatory protein "GO:0005886,GO:0016021,GO:0030141,GO:0030426,GO:0030672,GO:0044325,GO:0045955,GO:1901386,GO:1903170" plasma membrane|integral component of membrane|secretory granule|growth cone|synaptic vesicle membrane|ion channel binding|negative regulation of calcium ion-dependent exocytosis|negative regulation of voltage-gated calcium channel activity|negative regulation of calcium ion transmembrane transport CBFA2T2 999.2639275 1038.333055 960.1948 0.924746444 -0.112870247 0.648548643 1 6.166009432 5.606580126 9139 CBFA2/RUNX1 partner transcriptional co-repressor 2 "GO:0000122,GO:0003714,GO:0005515,GO:0005634,GO:0006351,GO:0010976,GO:0010977,GO:0045746,GO:0045892,GO:0046872,GO:0060575" "negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleus|transcription, DNA-templated|positive regulation of neuron projection development|negative regulation of neuron projection development|negative regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|metal ion binding|intestinal epithelial cell differentiation" CBFB 1771.067859 1744.774081 1797.361638 1.030140038 0.042840471 0.858874301 1 30.0081811 30.39534783 865 core-binding factor subunit beta "GO:0000122,GO:0000209,GO:0001649,GO:0001959,GO:0003713,GO:0005515,GO:0005654,GO:0006357,GO:0006366,GO:0006367,GO:0016020,GO:0016513,GO:0030098,GO:0030099,GO:0030111,GO:0033146,GO:0043371,GO:0043378,GO:0043565,GO:0045589,GO:0045616,GO:0045637,GO:0045652,GO:0045944,GO:0048469,GO:0050855,GO:0060216,GO:1902036,GO:2000810" "negative regulation of transcription by RNA polymerase II|protein polyubiquitination|osteoblast differentiation|regulation of cytokine-mediated signaling pathway|transcription coactivator activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|membrane|core-binding factor complex|lymphocyte differentiation|myeloid cell differentiation|regulation of Wnt signaling pathway|regulation of intracellular estrogen receptor signaling pathway|negative regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|sequence-specific DNA binding|regulation of regulatory T cell differentiation|regulation of keratinocyte differentiation|regulation of myeloid cell differentiation|regulation of megakaryocyte differentiation|positive regulation of transcription by RNA polymerase II|cell maturation|regulation of B cell receptor signaling pathway|definitive hemopoiesis|regulation of hematopoietic stem cell differentiation|regulation of bicellular tight junction assembly" CBF CBL 4406.579303 4672.498747 4140.659858 0.886176772 -0.174333582 0.465657737 1 22.32831934 19.45573203 867 Cbl proto-oncogene "GO:0000209,GO:0001784,GO:0004842,GO:0005154,GO:0005509,GO:0005515,GO:0005794,GO:0005829,GO:0005886,GO:0005925,GO:0005929,GO:0006511,GO:0006513,GO:0006974,GO:0007165,GO:0007166,GO:0007173,GO:0007175,GO:0007179,GO:0008543,GO:0008584,GO:0010332,GO:0014068,GO:0014823,GO:0016567,GO:0016600,GO:0017124,GO:0019221,GO:0030426,GO:0030971,GO:0032487,GO:0033574,GO:0035635,GO:0036120,GO:0036312,GO:0042059,GO:0042594,GO:0043066,GO:0043303,GO:0045121,GO:0045296,GO:0045471,GO:0045742,GO:0046677,GO:0046875,GO:0048260,GO:0048471,GO:0061024,GO:0061630,GO:0070102,GO:0070997,GO:0071364,GO:0090650,GO:1901215,GO:1990090,GO:2000583" protein polyubiquitination|phosphotyrosine residue binding|ubiquitin-protein transferase activity|epidermal growth factor receptor binding|calcium ion binding|protein binding|Golgi apparatus|cytosol|plasma membrane|focal adhesion|cilium|ubiquitin-dependent protein catabolic process|protein monoubiquitination|cellular response to DNA damage stimulus|signal transduction|cell surface receptor signaling pathway|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor-activated receptor activity|transforming growth factor beta receptor signaling pathway|fibroblast growth factor receptor signaling pathway|male gonad development|response to gamma radiation|positive regulation of phosphatidylinositol 3-kinase signaling|response to activity|protein ubiquitination|flotillin complex|SH3 domain binding|cytokine-mediated signaling pathway|growth cone|receptor tyrosine kinase binding|regulation of Rap protein signal transduction|response to testosterone|entry of bacterium into host cell|cellular response to platelet-derived growth factor stimulus|phosphatidylinositol 3-kinase regulatory subunit binding|negative regulation of epidermal growth factor receptor signaling pathway|response to starvation|negative regulation of apoptotic process|mast cell degranulation|membrane raft|cadherin binding|response to ethanol|positive regulation of epidermal growth factor receptor signaling pathway|response to antibiotic|ephrin receptor binding|positive regulation of receptor-mediated endocytosis|perinuclear region of cytoplasm|membrane organization|ubiquitin protein ligase activity|interleukin-6-mediated signaling pathway|neuron death|cellular response to epidermal growth factor stimulus|cellular response to oxygen-glucose deprivation|negative regulation of neuron death|cellular response to nerve growth factor stimulus|regulation of platelet-derived growth factor receptor-alpha signaling pathway "hsa04012,hsa04120,hsa04144,hsa04910,hsa05100,hsa05200,hsa05205,hsa05220" ErbB signaling pathway|Ubiquitin mediated proteolysis|Endocytosis|Insulin signaling pathway|Bacterial invasion of epithelial cells|Pathways in cancer|Proteoglycans in cancer|Chronic myeloid leukemia CBLB 432.8196631 449.4587973 416.1805289 0.925959246 -0.110979397 0.700870523 1 2.687595512 2.446960497 868 Cbl proto-oncogene B "GO:0001784,GO:0002669,GO:0005509,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006607,GO:0006955,GO:0007165,GO:0007175,GO:0008270,GO:0016567,GO:0017124,GO:0018193,GO:0030971,GO:0031398,GO:0035556,GO:0042110,GO:0043087,GO:0043393,GO:0045121,GO:0045732,GO:0046642,GO:0050852,GO:0050860,GO:0061630,GO:2000583" phosphotyrosine residue binding|positive regulation of T cell anergy|calcium ion binding|protein binding|nucleoplasm|cytosol|plasma membrane|NLS-bearing protein import into nucleus|immune response|signal transduction|negative regulation of epidermal growth factor-activated receptor activity|zinc ion binding|protein ubiquitination|SH3 domain binding|peptidyl-amino acid modification|receptor tyrosine kinase binding|positive regulation of protein ubiquitination|intracellular signal transduction|T cell activation|regulation of GTPase activity|regulation of protein binding|membrane raft|positive regulation of protein catabolic process|negative regulation of alpha-beta T cell proliferation|T cell receptor signaling pathway|negative regulation of T cell receptor signaling pathway|ubiquitin protein ligase activity|regulation of platelet-derived growth factor receptor-alpha signaling pathway "hsa04012,hsa04120,hsa04144,hsa04625,hsa04660,hsa04910,hsa05162" ErbB signaling pathway|Ubiquitin mediated proteolysis|Endocytosis|C-type lectin receptor signaling pathway|T cell receptor signaling pathway|Insulin signaling pathway|Measles CBLL1 814.6338939 859.3818671 769.8859208 0.895860095 -0.158654649 0.52945007 1 5.072849327 4.468516167 79872 Cbl proto-oncogene like 1 "GO:0000151,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0007162,GO:0007275,GO:0016567,GO:0016607,GO:0030155,GO:0030335,GO:0035635,GO:0036396,GO:0042802,GO:0045807,GO:0046872,GO:0061630,GO:0080009,GO:0098609" ubiquitin ligase complex|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|negative regulation of cell adhesion|multicellular organism development|protein ubiquitination|nuclear speck|regulation of cell adhesion|positive regulation of cell migration|entry of bacterium into host cell|RNA N6-methyladenosine methyltransferase complex|identical protein binding|positive regulation of endocytosis|metal ion binding|ubiquitin protein ligase activity|mRNA methylation|cell-cell adhesion CBLN2 14.29342203 9.363724944 19.22311912 2.052935048 1.037687984 0.303036018 1 0.077609068 0.156660265 147381 cerebellin 2 precursor "GO:0005615,GO:0050808,GO:0051965,GO:0098814,GO:0098978,GO:0099558,GO:1905606" extracellular space|synapse organization|positive regulation of synapse assembly|spontaneous synaptic transmission|glutamatergic synapse|maintenance of synapse structure|regulation of presynapse assembly CBLN3 18.4154486 16.64662212 20.18427508 1.212514763 0.278002313 0.805315523 1 0.358804373 0.427775533 643866 cerebellin 3 precursor "GO:0005615,GO:0005783,GO:0005794,GO:0045202" extracellular space|endoplasmic reticulum|Golgi apparatus|synapse CBR1 1795.201783 1583.509929 2006.893636 1.267370415 0.341838243 0.149460508 1 45.95378715 57.26589488 873 carbonyl reductase 1 "GO:0004090,GO:0005829,GO:0016655,GO:0017144,GO:0019371,GO:0030855,GO:0042373,GO:0047020,GO:0047021,GO:0050221,GO:0055114,GO:0070062,GO:1903561" "carbonyl reductase (NADPH) activity|cytosol|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|drug metabolic process|cyclooxygenase pathway|epithelial cell differentiation|vitamin K metabolic process|15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity|15-hydroxyprostaglandin dehydrogenase (NADP+) activity|prostaglandin-E2 9-reductase activity|oxidation-reduction process|extracellular exosome|extracellular vesicle" "hsa00590,hsa00790,hsa00980,hsa05204" Arachidonic acid metabolism|Folate biosynthesis|Metabolism of xenobiotics by cytochrome P450|Chemical carcinogenesis CBR3 274.3540765 238.2547791 310.4533738 1.303031045 0.381871457 0.240729667 1 8.897984372 11.40033413 874 carbonyl reductase 3 "GO:0000253,GO:0004090,GO:0005515,GO:0005615,GO:0005654,GO:0005829,GO:0006805,GO:0042376,GO:0050890,GO:0055114,GO:0070402" 3-keto sterol reductase activity|carbonyl reductase (NADPH) activity|protein binding|extracellular space|nucleoplasm|cytosol|xenobiotic metabolic process|phylloquinone catabolic process|cognition|oxidation-reduction process|NADPH binding "hsa00590,hsa00980" Arachidonic acid metabolism|Metabolism of xenobiotics by cytochrome P450 CBR4 663.3128102 608.6421213 717.9834991 1.179648062 0.238356508 0.357397773 1 7.223062348 8.378089605 84869 carbonyl reductase 4 "GO:0003955,GO:0005515,GO:0005759,GO:0006633,GO:0008753,GO:0016616,GO:0044597,GO:0044598,GO:0046949,GO:0047025,GO:0048038,GO:0051289,GO:0051290,GO:0055114,GO:0070402,GO:1990204" "NAD(P)H dehydrogenase (quinone) activity|protein binding|mitochondrial matrix|fatty acid biosynthetic process|NADPH dehydrogenase (quinone) activity|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|daunorubicin metabolic process|doxorubicin metabolic process|fatty-acyl-CoA biosynthetic process|3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity|quinone binding|protein homotetramerization|protein heterotetramerization|oxidation-reduction process|NADPH binding|oxidoreductase complex" hsa00061 Fatty acid biosynthesis CBS 104.235117 124.8496659 83.62056817 0.66977006 -0.57826221 0.210528112 1 1.925721736 1.26820786 875 cystathionine beta-synthase "GO:0004122,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006535,GO:0006563,GO:0006565,GO:0019343,GO:0019344,GO:0019346,GO:0019448,GO:0019825,GO:0019899,GO:0020037,GO:0030170,GO:0031625,GO:0042262,GO:0042802,GO:0042803,GO:0043418,GO:0046872,GO:0050421,GO:0050667,GO:0055114,GO:0070025,GO:0070026,GO:0070814,GO:0072341,GO:1904047" cystathionine beta-synthase activity|protein binding|nucleus|cytoplasm|cytosol|cysteine biosynthetic process from serine|L-serine metabolic process|L-serine catabolic process|cysteine biosynthetic process via cystathionine|cysteine biosynthetic process|transsulfuration|L-cysteine catabolic process|oxygen binding|enzyme binding|heme binding|pyridoxal phosphate binding|ubiquitin protein ligase binding|DNA protection|identical protein binding|protein homodimerization activity|homocysteine catabolic process|metal ion binding|nitrite reductase (NO-forming) activity|homocysteine metabolic process|oxidation-reduction process|carbon monoxide binding|nitric oxide binding|hydrogen sulfide biosynthetic process|modified amino acid binding|S-adenosyl-L-methionine binding "hsa00260,hsa00270" "Glycine, serine and threonine metabolism|Cysteine and methionine metabolism" CBSL 203.3518386 329.8112008 76.89247648 0.233140889 -2.100726045 2.80E-08 2.95E-05 4.502792944 1.032218416 102724560 cystathionine beta-synthase like "GO:0004122,GO:0005515,GO:0005634,GO:0005737,GO:0006535,GO:0019343,GO:0019346,GO:0020037,GO:0030170,GO:0046872,GO:0070814" cystathionine beta-synthase activity|protein binding|nucleus|cytoplasm|cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|transsulfuration|heme binding|pyridoxal phosphate binding|metal ion binding|hydrogen sulfide biosynthetic process "hsa00260,hsa00270" "Glycine, serine and threonine metabolism|Cysteine and methionine metabolism" CBWD1 165.2584594 149.8195991 180.6973197 1.206099341 0.27034874 0.49557515 1 2.58589801 3.066660157 55871 COBW domain containing 1 "GO:0005515,GO:0005524,GO:0005737" protein binding|ATP binding|cytoplasm CBWD2 189.3911539 190.3957405 188.3865674 0.989447384 -0.015305104 0.98315384 1 3.242205086 3.15430995 150472 COBW domain containing 2 "GO:0005524,GO:0005737" ATP binding|cytoplasm CBWD3 60.69121941 54.1015219 67.28091692 1.243604885 0.314528189 0.589209234 1 1.500675046 1.835017705 445571 COBW domain containing 3 "GO:0005515,GO:0005524,GO:0005737" protein binding|ATP binding|cytoplasm CBWD5 375.349065 353.7407201 396.9574098 1.122170526 0.166291925 0.57686058 1 5.332907368 5.884290109 220869 COBW domain containing 5 "GO:0005524,GO:0005737" ATP binding|cytoplasm CBWD6 84.9824298 98.83931885 71.12554074 0.719607759 -0.474717353 0.341795952 1 1.677225052 1.186747585 644019 COBW domain containing 6 "GO:0005524,GO:0005737" ATP binding|cytoplasm CBX1 2941.179773 2776.864653 3105.494894 1.11834579 0.161366335 0.49574655 1 56.69325281 62.34170295 10951 chromobox 1 "GO:0000775,GO:0000781,GO:0000785,GO:0000792,GO:0001939,GO:0001940,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005721,GO:0005819,GO:0006974,GO:0010369,GO:0019899,GO:0042802,GO:0045892,GO:0090734,GO:1990226" "chromosome, centromeric region|chromosome, telomeric region|chromatin|heterochromatin|female pronucleus|male pronucleus|chromatin binding|protein binding|nucleus|nucleoplasm|pericentric heterochromatin|spindle|cellular response to DNA damage stimulus|chromocenter|enzyme binding|identical protein binding|negative regulation of transcription, DNA-templated|site of DNA damage|histone methyltransferase binding" CBX2 167.0071642 183.1128433 150.9014851 0.82409012 -0.27912598 0.478987986 1 1.50321426 1.218054647 84733 chromobox 2 "GO:0000122,GO:0000791,GO:0000792,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0030154,GO:0031519,GO:0035064,GO:0035102,GO:0045137" negative regulation of transcription by RNA polymerase II|euchromatin|heterochromatin|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|chromatin organization|cell differentiation|PcG protein complex|methylated histone binding|PRC1 complex|development of primary sexual characteristics other CBX3 2889.881847 2767.500928 3012.262766 1.088441466 0.122263824 0.606015191 1 54.46033852 58.28497219 11335 chromobox 3 "GO:0000775,GO:0000779,GO:0000781,GO:0000785,GO:0000791,GO:0000792,GO:0005515,GO:0005634,GO:0005635,GO:0005637,GO:0005654,GO:0005721,GO:0005819,GO:0006338,GO:0006974,GO:0008134,GO:0019899,GO:0019904,GO:0035985,GO:0042802,GO:0045892,GO:0048511,GO:0070317,GO:0071549,GO:0090575,GO:0090734,GO:1990226" "chromosome, centromeric region|condensed chromosome, centromeric region|chromosome, telomeric region|chromatin|euchromatin|heterochromatin|protein binding|nucleus|nuclear envelope|nuclear inner membrane|nucleoplasm|pericentric heterochromatin|spindle|chromatin remodeling|cellular response to DNA damage stimulus|transcription factor binding|enzyme binding|protein domain specific binding|senescence-associated heterochromatin focus|identical protein binding|negative regulation of transcription, DNA-templated|rhythmic process|negative regulation of G0 to G1 transition|cellular response to dexamethasone stimulus|RNA polymerase II transcription regulator complex|site of DNA damage|histone methyltransferase binding" hsa05131 Shigellosis chromosome_remodelling_factor CBX4 573.613305 587.8338437 559.3927664 0.951617149 -0.071546824 0.792956449 1 6.931421088 6.485683057 8535 chromobox 4 "GO:0000122,GO:0000976,GO:0003682,GO:0003714,GO:0003727,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0016604,GO:0016607,GO:0016925,GO:0019789,GO:0019899,GO:0031519,GO:0032183,GO:0035064,GO:0035102,GO:0043066,GO:0045892,GO:0051219,GO:0061665" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|chromatin binding|transcription corepressor activity|single-stranded RNA binding|protein binding|nucleus|nucleoplasm|chromatin organization|nuclear body|nuclear speck|protein sumoylation|SUMO transferase activity|enzyme binding|PcG protein complex|SUMO binding|methylated histone binding|PRC1 complex|negative regulation of apoptotic process|negative regulation of transcription, DNA-templated|phosphoprotein binding|SUMO ligase activity" chromosome_remodelling_factor CBX5 4541.027894 4555.972392 4526.083397 0.993439601 -0.009495837 0.969325685 1 20.49598525 20.0208009 23468 chromobox 5 "GO:0000118,GO:0000122,GO:0000776,GO:0000781,GO:0000792,GO:0003682,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005721,GO:0005730,GO:0006974,GO:0007596,GO:0010369,GO:0016032,GO:0016605,GO:0017053,GO:0030674,GO:0032991,GO:0035064,GO:0035097,GO:0042802,GO:0042826,GO:0043021,GO:0044877,GO:0045892,GO:0070317,GO:0070491,GO:0090734,GO:1990904" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|kinetochore|chromosome, telomeric region|heterochromatin|chromatin binding|protein binding|nucleus|nuclear envelope|nucleoplasm|pericentric heterochromatin|nucleolus|cellular response to DNA damage stimulus|blood coagulation|chromocenter|viral process|PML body|transcription repressor complex|protein-macromolecule adaptor activity|protein-containing complex|methylated histone binding|histone methyltransferase complex|identical protein binding|histone deacetylase binding|ribonucleoprotein complex binding|protein-containing complex binding|negative regulation of transcription, DNA-templated|negative regulation of G0 to G1 transition|repressing transcription factor binding|site of DNA damage|ribonucleoprotein complex" CBX6 1381.088219 1423.286191 1338.890247 0.940703461 -0.088188082 0.715017544 1 12.55092005 11.6091249 23466 chromobox 6 "GO:0000122,GO:0000792,GO:0003727,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0031519" negative regulation of transcription by RNA polymerase II|heterochromatin|single-stranded RNA binding|protein binding|nucleus|nucleoplasm|chromatin organization|PcG protein complex CBX7 578.5184644 539.9748051 617.0621237 1.142760955 0.192523649 0.469557337 1 7.009842597 7.876528304 23492 chromobox 7 "GO:0000122,GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006325,GO:0031519,GO:0035102" negative regulation of transcription by RNA polymerase II|chromatin|protein binding|nucleus|nucleoplasm|cytosol|chromatin organization|PcG protein complex|PRC1 complex CBX8 108.0451423 111.3242854 104.7659992 0.94108845 -0.087597772 0.866942968 1 1.583468153 1.465247385 57332 chromobox 8 "GO:0000122,GO:0000785,GO:0000792,GO:0003727,GO:0005515,GO:0005634,GO:0005654,GO:0008284,GO:0016574,GO:0031519,GO:0032967,GO:0035064,GO:0035102,GO:0045739,GO:0050790,GO:0070301,GO:0097027" negative regulation of transcription by RNA polymerase II|chromatin|heterochromatin|single-stranded RNA binding|protein binding|nucleus|nucleoplasm|positive regulation of cell population proliferation|histone ubiquitination|PcG protein complex|positive regulation of collagen biosynthetic process|methylated histone binding|PRC1 complex|positive regulation of DNA repair|regulation of catalytic activity|cellular response to hydrogen peroxide|ubiquitin-protein transferase activator activity chromosome_remodelling_factor CBY1 574.6889318 502.5199053 646.8579584 1.287228529 0.364268206 0.169723357 1 20.85424864 26.39498274 25776 "chibby family member 1, beta catenin antagonist" "GO:0005515,GO:0005634,GO:0005654,GO:0005802,GO:0005814,GO:0005829,GO:0008013,GO:0008104,GO:0016607,GO:0030030,GO:0030178,GO:0042802,GO:0042803,GO:0042995,GO:0045444,GO:0045892,GO:0051289,GO:0055007" "protein binding|nucleus|nucleoplasm|trans-Golgi network|centriole|cytosol|beta-catenin binding|protein localization|nuclear speck|cell projection organization|negative regulation of Wnt signaling pathway|identical protein binding|protein homodimerization activity|cell projection|fat cell differentiation|negative regulation of transcription, DNA-templated|protein homotetramerization|cardiac muscle cell differentiation" hsa04310 Wnt signaling pathway CC2D1A 696.7545095 704.3601985 689.1488204 0.978403978 -0.031497825 0.907939778 1 10.34693345 9.954078113 54862 coiled-coil and C2 domain containing 1A "GO:0000978,GO:0000981,GO:0001227,GO:0001650,GO:0005515,GO:0005634,GO:0005815,GO:0005829,GO:0005886,GO:0006357,GO:0016020,GO:0043123,GO:0045296,GO:0070062,GO:1905381" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|fibrillar center|protein binding|nucleus|microtubule organizing center|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|cadherin binding|extracellular exosome|negative regulation of snRNA transcription by RNA polymerase II" CC2D1B 1052.12186 1151.738168 952.5055524 0.827015704 -0.27401337 0.263027585 1 7.57252054 6.157797389 200014 coiled-coil and C2 domain containing 1B "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0043231" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|intracellular membrane-bounded organelle" CC2D2A 389.1417873 413.0443114 365.2392633 0.884261696 -0.177454699 0.546558543 1 2.880739121 2.504701189 57545 coiled-coil and C2 domain containing 2A "GO:0005829,GO:0005856,GO:0007224,GO:0035869,GO:0036038,GO:0060271,GO:0097711" cytosol|cytoskeleton|smoothened signaling pathway|ciliary transition zone|MKS complex|cilium assembly|ciliary basal body-plasma membrane docking CC2D2B 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.016067783 387707 coiled-coil and C2 domain containing 2B CCAR1 1812.411428 1909.159475 1715.663381 0.898648544 -0.154171099 0.516214973 1 21.8738369 19.32796021 55749 cell division cycle and apoptosis regulator 1 "GO:0000398,GO:0000978,GO:0003713,GO:0003714,GO:0003723,GO:0005515,GO:0005634,GO:0005641,GO:0005654,GO:0006355,GO:0006915,GO:0007049,GO:0008284,GO:0030335,GO:0030374,GO:0043065,GO:0045892,GO:0045893,GO:0048471" "mRNA splicing, via spliceosome|RNA polymerase II cis-regulatory region sequence-specific DNA binding|transcription coactivator activity|transcription corepressor activity|RNA binding|protein binding|nucleus|nuclear envelope lumen|nucleoplasm|regulation of transcription, DNA-templated|apoptotic process|cell cycle|positive regulation of cell population proliferation|positive regulation of cell migration|nuclear receptor coactivator activity|positive regulation of apoptotic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|perinuclear region of cytoplasm" CCAR2 1766.499853 1751.016564 1781.983142 1.017684914 0.025290957 0.917536661 1 18.24454038 18.25649667 57805 cell cycle and apoptosis regulator 2 "GO:0000785,GO:0000993,GO:0003723,GO:0004857,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005759,GO:0005819,GO:0006355,GO:0006397,GO:0006974,GO:0007049,GO:0008380,GO:0009411,GO:0016055,GO:0019899,GO:0030308,GO:0030374,GO:0031647,GO:0032435,GO:0032784,GO:0042752,GO:0043065,GO:0043086,GO:0043653,GO:0044609,GO:0045892,GO:0045893,GO:0048511,GO:0090263,GO:0090311,GO:1900034,GO:1902230,GO:2000003" "chromatin|RNA polymerase II complex binding|RNA binding|enzyme inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrial matrix|spindle|regulation of transcription, DNA-templated|mRNA processing|cellular response to DNA damage stimulus|cell cycle|RNA splicing|response to UV|Wnt signaling pathway|enzyme binding|negative regulation of cell growth|nuclear receptor coactivator activity|regulation of protein stability|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA-templated transcription, elongation|regulation of circadian rhythm|positive regulation of apoptotic process|negative regulation of catalytic activity|mitochondrial fragmentation involved in apoptotic process|DBIRD complex|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|rhythmic process|positive regulation of canonical Wnt signaling pathway|regulation of protein deacetylation|regulation of cellular response to heat|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of DNA damage checkpoint" CCBE1 1284.438554 1257.860384 1311.016724 1.042259332 0.05971429 0.806960045 1 9.309346395 9.540390723 147372 collagen and calcium binding EGF domains 1 "GO:0001946,GO:0002020,GO:0002040,GO:0003016,GO:0005509,GO:0005515,GO:0005518,GO:0005581,GO:0005615,GO:0010575,GO:0010595,GO:0010954,GO:0030324,GO:0031012,GO:0045766,GO:0048845,GO:1900748,GO:1901492" lymphangiogenesis|protease binding|sprouting angiogenesis|respiratory system process|calcium ion binding|protein binding|collagen binding|collagen trimer|extracellular space|positive regulation of vascular endothelial growth factor production|positive regulation of endothelial cell migration|positive regulation of protein processing|lung development|extracellular matrix|positive regulation of angiogenesis|venous blood vessel morphogenesis|positive regulation of vascular endothelial growth factor signaling pathway|positive regulation of lymphangiogenesis CCDC102A 276.0732131 245.5376763 306.60875 1.24872384 0.320454454 0.324863415 1 3.4657219 4.255310866 92922 coiled-coil domain containing 102A "GO:0003774,GO:0016459" motor activity|myosin complex CCDC103 61.8058608 70.74814402 52.86357758 0.747207977 -0.420418238 0.45788043 1 1.091557796 0.801972385 388389 coiled-coil domain containing 103 "GO:0001947,GO:0003341,GO:0003351,GO:0005515,GO:0005576,GO:0005737,GO:0005930,GO:0007368,GO:0031514,GO:0036157,GO:0036158,GO:0036159,GO:0042803,GO:0060287,GO:0070286,GO:0071907" heart looping|cilium movement|epithelial cilium movement involved in extracellular fluid movement|protein binding|extracellular region|cytoplasm|axoneme|determination of left/right symmetry|motile cilium|outer dynein arm|outer dynein arm assembly|inner dynein arm assembly|protein homodimerization activity|epithelial cilium movement involved in determination of left/right asymmetry|axonemal dynein complex assembly|determination of digestive tract left/right asymmetry CCDC106 215.1240983 235.1335375 195.1146591 0.829803614 -0.269158155 0.450636962 1 4.336090096 3.537893846 29903 coiled-coil domain containing 106 "GO:0005515,GO:0005654,GO:0005829" protein binding|nucleoplasm|cytosol CCDC107 336.7197732 311.0837509 362.3557954 1.164817495 0.220103929 0.472326603 1 13.13446838 15.04324619 203260 coiled-coil domain containing 107 "GO:0005515,GO:0016021" protein binding|integral component of membrane CCDC110 12.81205913 8.323311061 17.30080721 2.078596736 1.055609892 0.32011204 1 0.122639374 0.250652099 256309 coiled-coil domain containing 110 "GO:0005515,GO:0005634,GO:0005856" protein binding|nucleus|cytoskeleton CCDC112 330.546487 325.6495453 335.4434286 1.030074918 0.042749269 0.898782728 1 6.278655243 6.359260677 153733 coiled-coil domain containing 112 GO:0005515 protein binding CCDC113 77.61524427 94.67766332 60.55282523 0.639568227 -0.644829827 0.208374847 1 0.663703255 0.417380357 29070 coiled-coil domain containing 113 "GO:0005515,GO:0005930,GO:0032991,GO:0034451,GO:0036064,GO:0060271" protein binding|axoneme|protein-containing complex|centriolar satellite|ciliary basal body|cilium assembly CCDC115 406.5218525 415.1251392 397.9185658 0.958550876 -0.061073089 0.839905272 1 9.691367327 9.134218617 84317 coiled-coil domain containing 115 "GO:0005515,GO:0005764,GO:0005768,GO:0005783,GO:0005793,GO:0006879,GO:0007042,GO:0016020,GO:0016471,GO:0030137,GO:0036295,GO:0042406,GO:0051082,GO:0070072,GO:1905146" protein binding|lysosome|endosome|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cellular iron ion homeostasis|lysosomal lumen acidification|membrane|vacuolar proton-transporting V-type ATPase complex|COPI-coated vesicle|cellular response to increased oxygen levels|extrinsic component of endoplasmic reticulum membrane|unfolded protein binding|vacuolar proton-transporting V-type ATPase complex assembly|lysosomal protein catabolic process CCDC116 5.484502575 5.202069413 5.766935736 1.108584926 0.148719296 1 1 0.078270337 0.085317348 164592 coiled-coil domain containing 116 "GO:0005515,GO:0005737,GO:0005813" protein binding|cytoplasm|centrosome CCDC117 877.5946394 846.8969005 908.2923784 1.072494631 0.100970425 0.688186941 1 11.1405795 11.74827456 150275 coiled-coil domain containing 117 GO:0005515 protein binding CCDC12 409.132948 395.3572754 422.9086206 1.069687209 0.097188995 0.741909476 1 2.839005806 2.986030656 151903 coiled-coil domain containing 12 "GO:0005515,GO:0005684,GO:0071014" protein binding|U2-type spliceosomal complex|post-mRNA release spliceosomal complex hsa03040 Spliceosome CCDC120 14.97214483 14.56579436 15.3784953 1.055795168 0.078329968 1 1 0.204243214 0.212030572 90060 coiled-coil domain containing 120 "GO:0005515,GO:0005768,GO:0005814,GO:0007275,GO:0008104,GO:0030426,GO:0034454,GO:0120103" protein binding|endosome|centriole|multicellular organism development|protein localization|growth cone|microtubule anchoring at centrosome|centriolar subdistal appendage CCDC121 18.65322238 22.88910542 14.41733934 0.629877799 -0.666856133 0.466154686 1 0.420788663 0.26061026 79635 coiled-coil domain containing 121 GO:0005515 protein binding CCDC122 121.9718428 136.2942186 107.6494671 0.7898315 -0.340383189 0.44110186 1 1.429874572 1.110461668 160857 coiled-coil domain containing 122 CCDC124 885.8883824 837.5331755 934.2435892 1.115470547 0.157652421 0.528121755 1 41.27202794 45.26735248 115098 coiled-coil domain containing 124 "GO:0003723,GO:0005815,GO:0005829,GO:0005886,GO:0007049,GO:0030496,GO:0051301" RNA binding|microtubule organizing center|cytosol|plasma membrane|cell cycle|midbody|cell division CCDC125 408.0774429 430.7313474 385.4235384 0.894811907 -0.160343641 0.581569132 1 4.424897086 3.893194556 202243 coiled-coil domain containing 125 "GO:0003674,GO:0005515,GO:0005737,GO:0035024,GO:0042802,GO:0090630,GO:2000146" molecular_function|protein binding|cytoplasm|negative regulation of Rho protein signal transduction|identical protein binding|activation of GTPase activity|negative regulation of cell motility CCDC126 162.528477 166.4662212 158.5907327 0.952690171 -0.069920991 0.874181713 1 3.213018544 3.009789309 90693 coiled-coil domain containing 126 "GO:0005576,GO:0016020" extracellular region|membrane CCDC127 553.7366152 520.2069413 587.2662891 1.128908983 0.174929175 0.515555426 1 2.990680638 3.319709998 133957 coiled-coil domain containing 127 CCDC13 5.524131538 6.242483296 4.80577978 0.769850643 -0.377349516 0.927604977 1 0.034476856 0.026097885 152206 coiled-coil domain containing 13 "GO:0005515,GO:0005654,GO:0005813,GO:0005829,GO:0006974,GO:0031122,GO:0034451,GO:0042995,GO:1905515" protein binding|nucleoplasm|centrosome|cytosol|cellular response to DNA damage stimulus|cytoplasmic microtubule organization|centriolar satellite|cell projection|non-motile cilium assembly CCDC130 315.0887337 323.5687175 306.60875 0.94758465 -0.077673266 0.811106328 1 8.452407126 7.875345268 81576 coiled-coil domain containing 130 "GO:0005515,GO:0005575,GO:0005684,GO:0008380,GO:0009615,GO:0071014" protein binding|cellular_component|U2-type spliceosomal complex|RNA splicing|response to virus|post-mRNA release spliceosomal complex CCDC134 478.9350273 499.3986637 458.471391 0.918046892 -0.12336025 0.659824399 1 3.694993598 3.335413894 79879 coiled-coil domain containing 134 "GO:0001525,GO:0001890,GO:0005515,GO:0005576,GO:0005634,GO:0005783,GO:0016020,GO:0021591,GO:0035162,GO:1990402" angiogenesis|placenta development|protein binding|extracellular region|nucleus|endoplasmic reticulum|membrane|ventricular system development|embryonic hemopoiesis|embryonic liver development CCDC136 458.4337206 491.0753526 425.7920885 0.867060597 -0.205795271 0.463405254 1 5.011049524 4.27217785 64753 coiled-coil domain containing 136 "GO:0001675,GO:0002080,GO:0007283,GO:0007338,GO:0016021" acrosome assembly|acrosomal membrane|spermatogenesis|single fertilization|integral component of membrane CCDC137 1082.497652 1103.879129 1061.116175 0.961261199 -0.056999594 0.818690414 1 22.18907732 20.97257879 339230 coiled-coil domain containing 137 "GO:0001650,GO:0003723,GO:0005515,GO:0005694,GO:0005730" fibrillar center|RNA binding|protein binding|chromosome|nucleolus CCDC138 152.7533711 174.7895323 130.71721 0.74785491 -0.419169691 0.299985426 1 1.766703805 1.299128985 165055 coiled-coil domain containing 138 CCDC14 2490.76055 2571.903118 2409.617982 0.936900758 -0.094031857 0.691786184 1 16.16508567 14.89164861 64770 coiled-coil domain containing 14 "GO:0005515,GO:0005737,GO:0005813,GO:0021762,GO:0034451,GO:0071539" protein binding|cytoplasm|centrosome|substantia nigra development|centriolar satellite|protein localization to centrosome CCDC142 143.5531925 147.7387713 139.3676136 0.943338112 -0.084153139 0.854151063 1 1.910016156 1.771640502 84865 coiled-coil domain containing 142 CCDC146 25.460572 24.96993318 25.95121081 1.039298368 0.055609892 1 1 0.399580042 0.408333689 57639 coiled-coil domain containing 146 "GO:0005515,GO:0005737,GO:0005814,GO:0005856" protein binding|cytoplasm|centriole|cytoskeleton CCDC148 22.26007242 16.64662212 27.87352272 1.674425149 0.743665885 0.375505823 1 0.235524822 0.387769459 130940 coiled-coil domain containing 148 GO:0005515 protein binding CCDC149 20.29813155 15.60620824 24.99005486 1.601289338 0.679234013 0.441168313 1 0.119340113 0.187900284 91050 coiled-coil domain containing 149 CCDC15 322.3024338 311.0837509 333.5211167 1.072126447 0.100475068 0.752141667 1 2.965696327 3.126395143 80071 coiled-coil domain containing 15 GO:0005813 centrosome CCDC150 183.4160126 210.1636043 156.6684208 0.745459336 -0.423798438 0.260364521 1 2.101957514 1.540703504 284992 coiled-coil domain containing 150 GO:0005515 protein binding CCDC153 12.33148116 8.323311061 16.33965125 1.96311914 0.973147731 0.371650685 1 0.329036899 0.635129726 283152 coiled-coil domain containing 153 GO:0005515 protein binding CCDC157 32.22829265 26.01034707 38.44623824 1.478113235 0.563756795 0.438750601 1 0.415606113 0.604033202 550631 coiled-coil domain containing 157 GO:0005515 protein binding CCDC159 34.98784321 35.37407201 34.60161442 0.97816317 -0.03185295 1 1 1.097586749 1.055653375 126075 coiled-coil domain containing 159 CCDC163 113.8863056 125.8900798 101.8825313 0.809297536 -0.305257893 0.502297332 1 2.97543055 2.367713849 126661 coiled-coil domain containing 163 GO:0016021 integral component of membrane CCDC167 163.2518592 160.2237379 166.2799804 1.037798659 0.053526577 0.907683039 1 14.94903219 15.25447835 154467 coiled-coil domain containing 167 "GO:0005515,GO:0016021" protein binding|integral component of membrane CCDC169 20.09495631 22.88910542 17.30080721 0.755853359 -0.403821727 0.671462766 1 0.186895576 0.13890176 728591 coiled-coil domain containing 169 CCDC17 15.61123866 18.72744989 12.49502743 0.667203891 -0.583800393 0.567501483 1 0.302955314 0.198750543 149483 coiled-coil domain containing 17 GO:0005515 protein binding CCDC170 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.010108315 0.036728034 80129 coiled-coil domain containing 170 "GO:0000226,GO:0005515,GO:0005794,GO:0008017,GO:0036064" microtubule cytoskeleton organization|protein binding|Golgi apparatus|microtubule binding|ciliary basal body CCDC171 43.71750474 37.45489978 49.98010971 1.334407781 0.416199607 0.524587078 1 0.146482424 0.192196406 203238 coiled-coil domain containing 171 CCDC173 9.086322201 11.44455271 6.728091692 0.587885946 -0.766391806 0.566347083 1 0.278765287 0.161139848 129881 coiled-coil domain containing 173 CCDC174 448.0195209 495.2370081 400.8020336 0.809313575 -0.3052293 0.277491049 1 7.4576436 5.934575077 51244 coiled-coil domain containing 174 "GO:0005515,GO:0005634,GO:0005654" protein binding|nucleus|nucleoplasm CCDC178 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.036465615 0 374864 coiled-coil domain containing 178 GO:0036064 ciliary basal body CCDC18 345.9790881 390.155206 301.8029702 0.773545926 -0.370441146 0.219250811 1 1.920659189 1.460856611 343099 coiled-coil domain containing 18 CCDC180 170.0195798 161.2641518 178.7750078 1.108584926 0.148719296 0.711788269 1 1.148894859 1.252334756 100499483 coiled-coil domain containing 180 GO:0070062 extracellular exosome CCDC183 40.83403688 37.45489978 44.21317398 1.180437653 0.239321845 0.740072919 1 1.164859651 1.35203469 84960 coiled-coil domain containing 183 CCDC184 12.29185219 7.282897178 17.30080721 2.375539127 1.248254969 0.245646158 1 0.17024741 0.397661806 387856 coiled-coil domain containing 184 "GO:0005515,GO:0005737" protein binding|cytoplasm CCDC186 288.1021395 309.0029231 267.2013558 0.864721126 -0.209693158 0.516602694 1 1.899875355 1.615371281 55088 coiled-coil domain containing 186 "GO:0005794,GO:0009617,GO:0035773,GO:0099518" Golgi apparatus|response to bacterium|insulin secretion involved in cellular response to glucose stimulus|vesicle cytoskeletal trafficking CCDC188 82.54997178 72.82897178 92.27097178 1.266954201 0.341364374 0.505209937 1 2.184793912 2.721714529 388849 coiled-coil domain containing 188 GO:0016021 integral component of membrane CCDC189 96.87799236 95.7180772 98.03790751 1.024236073 0.034548276 0.966018296 1 2.699946014 2.719107178 90835 coiled-coil domain containing 189 CCDC190 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.022632463 0.034264112 339512 coiled-coil domain containing 190 CCDC191 228.6444483 274.669265 182.6196316 0.66487101 -0.588853621 0.088249627 1 2.035915813 1.330970382 57577 coiled-coil domain containing 191 CCDC192 6.485287494 6.242483296 6.728091692 1.0777909 0.108077311 1 1 0.048949436 0.051874435 728586 coiled-coil domain containing 192 CCDC194 3.403674809 1.040413883 5.766935736 5.54292463 2.470647391 0.304382079 1 0.04187404 0.228220689 110806280 CCDC22 484.5830762 496.277422 472.8887303 0.952871739 -0.069646061 0.806824584 1 11.45067613 10.72844445 28952 coiled-coil domain containing 22 "GO:0005515,GO:0005575,GO:0005654,GO:0005768,GO:0005829,GO:0006878,GO:0006893,GO:0007253,GO:0015031,GO:0016567,GO:0032456,GO:0043123,GO:0043124,GO:0043687,GO:0097602,GO:1990126,GO:2000060" "protein binding|cellular_component|nucleoplasm|endosome|cytosol|cellular copper ion homeostasis|Golgi to plasma membrane transport|cytoplasmic sequestering of NF-kappaB|protein transport|protein ubiquitination|endocytic recycling|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|post-translational protein modification|cullin family protein binding|retrograde transport, endosome to plasma membrane|positive regulation of ubiquitin-dependent protein catabolic process" CCDC24 103.8042289 100.9201466 106.6883111 1.057155728 0.080187914 0.882835522 1 3.564475673 3.705150054 149473 coiled-coil domain containing 24 "GO:0001835,GO:0005515" blastocyst hatching|protein binding CCDC25 667.7914975 625.2887435 710.2942515 1.135946007 0.183894264 0.478236277 1 9.033706282 10.09008521 55246 coiled-coil domain containing 25 GO:0005515 protein binding CCDC28A 278.7931347 253.8609874 303.7252821 1.196423622 0.258728301 0.426776966 1 6.567180959 7.725651995 25901 coiled-coil domain containing 28A GO:0005515 protein binding CCDC28B 107.9709148 96.75849109 119.1833385 1.231761029 0.300722389 0.517905017 1 2.629237696 3.18439907 79140 coiled-coil domain containing 28B "GO:0005515,GO:0005737,GO:0005813,GO:0060271" protein binding|cytoplasm|centrosome|cilium assembly CCDC3 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.013757427 0.037490168 83643 coiled-coil domain containing 3 "GO:0005576,GO:0005783,GO:0010629,GO:0010804,GO:0045600,GO:0045833,GO:0046889,GO:0051055" extracellular region|endoplasmic reticulum|negative regulation of gene expression|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of fat cell differentiation|negative regulation of lipid metabolic process|positive regulation of lipid biosynthetic process|negative regulation of lipid biosynthetic process CCDC30 7.124381325 10.40413883 3.844623824 0.369528309 -1.436243205 0.311438224 1 0.067870647 0.024660444 728621 coiled-coil domain containing 30 CCDC32 228.8230859 228.8910542 228.7551175 0.999406108 -0.00085706 1 1 2.704936864 2.658093849 90416 coiled-coil domain containing 32 GO:0005515 protein binding CCDC34 401.0474107 384.9531366 417.1416849 1.083616797 0.115854662 0.69460209 1 7.047767199 7.509282746 91057 coiled-coil domain containing 34 CCDC39 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.043288703 0.052429077 339829 coiled-coil domain containing 39 "GO:0001947,GO:0003341,GO:0003356,GO:0005576,GO:0005829,GO:0005929,GO:0005930,GO:0007420,GO:0030317,GO:0030324,GO:0035469,GO:0036159,GO:0044458,GO:0051649,GO:0060285,GO:0060287,GO:0061512,GO:0061966,GO:0070286,GO:0071907,GO:0071910,GO:0090660" heart looping|cilium movement|regulation of cilium beat frequency|extracellular region|cytosol|cilium|axoneme|brain development|flagellated sperm motility|lung development|determination of pancreatic left/right asymmetry|inner dynein arm assembly|motile cilium assembly|establishment of localization in cell|cilium-dependent cell motility|epithelial cilium movement involved in determination of left/right asymmetry|protein localization to cilium|establishment of left/right asymmetry|axonemal dynein complex assembly|determination of digestive tract left/right asymmetry|determination of liver left/right asymmetry|cerebrospinal fluid circulation CCDC40 26.21855272 32.25283036 20.18427508 0.625814071 -0.676193998 0.387573448 1 0.209860312 0.129135847 55036 coiled-coil domain containing 40 "GO:0001947,GO:0003341,GO:0003351,GO:0003356,GO:0003674,GO:0005576,GO:0005737,GO:0005929,GO:0005930,GO:0030317,GO:0030324,GO:0035082,GO:0035469,GO:0036159,GO:0044458,GO:0060287,GO:0070286,GO:0071907,GO:0071910" heart looping|cilium movement|epithelial cilium movement involved in extracellular fluid movement|regulation of cilium beat frequency|molecular_function|extracellular region|cytoplasm|cilium|axoneme|flagellated sperm motility|lung development|axoneme assembly|determination of pancreatic left/right asymmetry|inner dynein arm assembly|motile cilium assembly|epithelial cilium movement involved in determination of left/right asymmetry|axonemal dynein complex assembly|determination of digestive tract left/right asymmetry|determination of liver left/right asymmetry CCDC43 465.5090265 424.4888641 506.5291888 1.193268497 0.2549187 0.360815983 1 10.71626798 12.57340541 124808 coiled-coil domain containing 43 "GO:0005515,GO:0005829" protein binding|cytosol CCDC47 2039.526052 2004.877552 2074.174553 1.034564206 0.049023183 0.837659053 1 30.85254617 31.38481971 57003 coiled-coil domain containing 47 "GO:0001649,GO:0003723,GO:0005509,GO:0005515,GO:0005783,GO:0006983,GO:0007029,GO:0009791,GO:0016020,GO:0016021,GO:0030433,GO:0030867,GO:0032469,GO:0036503" osteoblast differentiation|RNA binding|calcium ion binding|protein binding|endoplasmic reticulum|ER overload response|endoplasmic reticulum organization|post-embryonic development|membrane|integral component of membrane|ubiquitin-dependent ERAD pathway|rough endoplasmic reticulum membrane|endoplasmic reticulum calcium ion homeostasis|ERAD pathway CCDC50 3478.181676 3084.827162 3871.536191 1.255025318 0.327716469 0.167425368 1 18.35357369 22.64875352 152137 coiled-coil domain containing 50 "GO:0005515,GO:0005829,GO:0007605,GO:0031625" protein binding|cytosol|sensory perception of sound|ubiquitin protein ligase binding CCDC51 321.9703109 340.2153396 303.7252821 0.892744232 -0.163681187 0.600466469 1 8.27560045 7.264366484 79714 coiled-coil domain containing 51 "GO:0005515,GO:0031305,GO:0062156,GO:0062157,GO:0071805" protein binding|integral component of mitochondrial inner membrane|mitochondrial ATP-gated potassium channel activity|mitochondrial ATP-gated potassium channel complex|potassium ion transmembrane transport CCDC57 535.6325535 625.2887435 445.9763636 0.713232676 -0.487555295 0.069839221 1 2.402484594 1.684856902 284001 coiled-coil domain containing 57 "GO:0000086,GO:0005515,GO:0005813,GO:0005814,GO:0005876,GO:0007020,GO:0007099,GO:0034451,GO:0045931,GO:0060271" G2/M transition of mitotic cell cycle|protein binding|centrosome|centriole|spindle microtubule|microtubule nucleation|centriole replication|centriolar satellite|positive regulation of mitotic cell cycle|cilium assembly CCDC59 576.2445223 518.1261136 634.362931 1.224340782 0.292005172 0.271264834 1 17.44570246 21.00206294 29080 coiled-coil domain containing 59 "GO:0003723,GO:0005515,GO:0005654,GO:0044267" RNA binding|protein binding|nucleoplasm|cellular protein metabolic process CCDC6 2105.60178 2212.960328 1998.243233 0.902972912 -0.147245385 0.534197956 1 20.62190073 18.30942024 8030 coiled-coil domain containing 6 "GO:0005200,GO:0005515,GO:0005829,GO:0005856,GO:0007010,GO:0008150,GO:0017124,GO:0042802" structural constituent of cytoskeleton|protein binding|cytosol|cytoskeleton|cytoskeleton organization|biological_process|SH3 domain binding|identical protein binding "hsa05200,hsa05216" Pathways in cancer|Thyroid cancer CCDC61 185.9528806 175.8299462 196.075815 1.1151446 0.157230796 0.683907313 1 1.95861429 2.147589556 729440 coiled-coil domain containing 61 "GO:0005515,GO:0005737,GO:0005813,GO:0005815,GO:0008017,GO:0030030,GO:0034451,GO:0036064,GO:0042802,GO:0090307,GO:0098534,GO:0120103" protein binding|cytoplasm|centrosome|microtubule organizing center|microtubule binding|cell projection organization|centriolar satellite|ciliary basal body|identical protein binding|mitotic spindle assembly|centriole assembly|centriolar subdistal appendage CCDC62 9.527271215 10.40413883 8.650403604 0.831438695 -0.266318203 0.910300494 1 0.132391456 0.108233417 84660 coiled-coil domain containing 62 "GO:0001835,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0030331,GO:0030374,GO:0045944,GO:0071392" blastocyst hatching|protein binding|nucleus|nucleoplasm|cytoplasm|plasma membrane|estrogen receptor binding|nuclear receptor coactivator activity|positive regulation of transcription by RNA polymerase II|cellular response to estradiol stimulus CCDC66 240.5500717 246.5780902 234.5220533 0.951106617 -0.072321021 0.842672888 1 3.510114559 3.282628022 285331 coiled-coil domain containing 66 "GO:0001578,GO:0001750,GO:0001895,GO:0001917,GO:0005515,GO:0005813,GO:0005829,GO:0005874,GO:0005929,GO:0008017,GO:0030054,GO:0034451,GO:0035869,GO:0036064,GO:0042803,GO:0050908,GO:0060271,GO:0090543,GO:1903564" microtubule bundle formation|photoreceptor outer segment|retina homeostasis|photoreceptor inner segment|protein binding|centrosome|cytosol|microtubule|cilium|microtubule binding|cell junction|centriolar satellite|ciliary transition zone|ciliary basal body|protein homodimerization activity|detection of light stimulus involved in visual perception|cilium assembly|Flemming body|regulation of protein localization to cilium CCDC68 1102.900194 1059.141333 1146.659056 1.082630826 0.114541372 0.64061334 1 12.4311472 13.23313601 80323 coiled-coil domain containing 68 "GO:0005515,GO:0005622,GO:0005737,GO:0005814,GO:0008104,GO:0034454,GO:0035556,GO:0120103" protein binding|intracellular anatomical structure|cytoplasm|centriole|protein localization|microtubule anchoring at centrosome|intracellular signal transduction|centriolar subdistal appendage CCDC69 411.0703512 357.9023756 464.2383267 1.297108816 0.375299514 0.191457188 1 5.621127719 7.169205724 26112 coiled-coil domain containing 69 "GO:0005634,GO:0005737,GO:0008017,GO:0030496,GO:0051233,GO:0051255" nucleus|cytoplasm|microtubule binding|midbody|spindle midzone|spindle midzone assembly CCDC7 14.97214483 14.56579436 15.3784953 1.055795168 0.078329968 1 1 0.103398467 0.10734083 79741 coiled-coil domain containing 7 CCDC71 322.9761262 328.7707869 317.1814655 0.96474954 -0.051773644 0.87617785 1 9.796701643 9.293207638 64925 coiled-coil domain containing 71 CCDC71L 2419.494656 2025.68583 2813.303483 1.388815305 0.473854752 0.045194691 1 15.9004456 21.71325676 168455 coiled-coil domain containing 71 like "GO:0044255,GO:0045600" cellular lipid metabolic process|positive regulation of fat cell differentiation CCDC73 2.962725795 2.080827765 3.844623824 1.847641543 0.88568489 0.829811711 1 0.032709854 0.059424769 493860 coiled-coil domain containing 73 CCDC74A 172.4174393 173.7491184 171.0857602 0.984671242 -0.022285971 0.970555455 1 3.268477657 3.16452079 90557 coiled-coil domain containing 74A GO:0005515 protein binding CCDC74B 67.33502276 64.50566072 70.16438479 1.087724457 0.121313139 0.847503479 1 1.978476182 2.116025507 91409 coiled-coil domain containing 74B CCDC77 504.8415788 510.8432164 498.8399412 0.976503015 -0.034303596 0.907322476 1 11.17326376 10.72814953 84318 coiled-coil domain containing 77 "GO:0005813,GO:0016020" centrosome|membrane CCDC78 25.57945889 28.09117483 23.06774294 0.821174019 -0.284240111 0.751299502 1 0.577049412 0.465928613 124093 coiled-coil domain containing 78 "GO:0003009,GO:0005814,GO:0016529,GO:0030030,GO:0042383,GO:0048471,GO:0098535,GO:0098536" skeletal muscle contraction|centriole|sarcoplasmic reticulum|cell projection organization|sarcolemma|perinuclear region of cytoplasm|de novo centriole assembly involved in multi-ciliated epithelial cell differentiation|deuterosome CCDC80 482.2399369 447.3779695 517.1019043 1.155850175 0.208954403 0.45090984 1 1.940959271 2.205916879 151887 coiled-coil domain containing 80 "GO:0001968,GO:0005604,GO:0005614,GO:0008201,GO:0009617,GO:0010811,GO:0030198" fibronectin binding|basement membrane|interstitial matrix|heparin binding|response to bacterium|positive regulation of cell-substrate adhesion|extracellular matrix organization CCDC81 6.406029567 4.161655531 8.650403604 2.078596736 1.055609892 0.509812894 1 0.048567659 0.099263274 60494 coiled-coil domain containing 81 "GO:0005515,GO:0005737,GO:0005813" protein binding|cytoplasm|centrosome CCDC82 1193.560241 1180.869757 1206.250725 1.021493452 0.030679957 0.902704005 1 9.420156737 9.461606773 79780 coiled-coil domain containing 82 GO:0005634 nucleus CCDC85A 30.46449659 30.1720026 30.75699059 1.019388438 0.027703895 1 1 0.382203732 0.383094402 114800 coiled-coil domain containing 85A "GO:0005515,GO:0005912,GO:0008150" protein binding|adherens junction|biological_process CCDC85B 1425.653638 1344.214736 1507.092539 1.121169481 0.16500438 0.49141665 1 74.49456897 82.12342582 11007 coiled-coil domain containing 85B "GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005912,GO:0016032,GO:0030154,GO:0030308,GO:0045599,GO:0045892,GO:0070097" "protein binding|nucleus|cytoplasm|centrosome|adherens junction|viral process|cell differentiation|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of transcription, DNA-templated|delta-catenin binding" CCDC85C 1099.779567 951.9787026 1247.580431 1.310512964 0.390131625 0.109629048 1 2.595685572 3.34475709 317762 coiled-coil domain containing 85C "GO:0005912,GO:0005923,GO:0021987,GO:0043296" adherens junction|bicellular tight junction|cerebral cortex development|apical junction complex CCDC86 836.180645 857.3010393 815.0602507 0.950728173 -0.072895183 0.774751963 1 24.71776381 23.10663585 79080 coiled-coil domain containing 86 "GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0016032" RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|viral process CCDC88A 2357.719708 2573.983946 2141.45547 0.831961471 -0.265411378 0.261525327 1 11.56205643 9.458221431 55704 coiled-coil domain containing 88A "GO:0001932,GO:0001965,GO:0003779,GO:0005080,GO:0005085,GO:0005092,GO:0005154,GO:0005158,GO:0005515,GO:0005737,GO:0005783,GO:0005794,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0006260,GO:0006275,GO:0007264,GO:0007399,GO:0008017,GO:0010975,GO:0016020,GO:0016477,GO:0030027,GO:0030032,GO:0030142,GO:0030705,GO:0031122,GO:0031410,GO:0031682,GO:0031929,GO:0032147,GO:0032148,GO:0032956,GO:0035091,GO:0036064,GO:0042127,GO:0042169,GO:0042803,GO:0043184,GO:0043422,GO:0045724,GO:0045742,GO:0051496,GO:0051959,GO:0061024,GO:0072660,GO:1903566" regulation of protein phosphorylation|G-protein alpha-subunit binding|actin binding|protein kinase C binding|guanyl-nucleotide exchange factor activity|GDP-dissociation inhibitor activity|epidermal growth factor receptor binding|insulin receptor binding|protein binding|cytoplasm|endoplasmic reticulum|Golgi apparatus|centrosome|centriole|cytosol|plasma membrane|DNA replication|regulation of DNA replication|small GTPase mediated signal transduction|nervous system development|microtubule binding|regulation of neuron projection development|membrane|cell migration|lamellipodium|lamellipodium assembly|COPI-coated Golgi to ER transport vesicle|cytoskeleton-dependent intracellular transport|cytoplasmic microtubule organization|cytoplasmic vesicle|G-protein gamma-subunit binding|TOR signaling|activation of protein kinase activity|activation of protein kinase B activity|regulation of actin cytoskeleton organization|phosphatidylinositol binding|ciliary basal body|regulation of cell population proliferation|SH2 domain binding|protein homodimerization activity|vascular endothelial growth factor receptor 2 binding|protein kinase B binding|positive regulation of cilium assembly|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of stress fiber assembly|dynein light intermediate chain binding|membrane organization|maintenance of protein location in plasma membrane|positive regulation of protein localization to cilium CCDC88B 79.49792722 93.63724944 65.35860501 0.697997916 -0.518705365 0.309609701 1 0.865174499 0.593784716 283234 coiled-coil domain containing 88B "GO:0001819,GO:0005515,GO:0005737,GO:0005783,GO:0005794,GO:0005813,GO:0008017,GO:0016020,GO:0030705,GO:0031122,GO:0042102,GO:0042832,GO:0050870,GO:0051959" positive regulation of cytokine production|protein binding|cytoplasm|endoplasmic reticulum|Golgi apparatus|centrosome|microtubule binding|membrane|cytoskeleton-dependent intracellular transport|cytoplasmic microtubule organization|positive regulation of T cell proliferation|defense response to protozoan|positive regulation of T cell activation|dynein light intermediate chain binding CCDC88C 260.3424732 324.6091314 196.075815 0.604036658 -0.727291987 0.027689406 0.877967194 2.044829171 1.214483187 440193 coiled-coil domain containing 88C "GO:0001932,GO:0001965,GO:0003383,GO:0005085,GO:0005109,GO:0005515,GO:0005737,GO:0005813,GO:0007264,GO:0008017,GO:0030054,GO:0030165,GO:0030705,GO:0031098,GO:0031122,GO:0031648,GO:0035567,GO:0042802,GO:0043621,GO:0050790,GO:0051959,GO:0090090" regulation of protein phosphorylation|G-protein alpha-subunit binding|apical constriction|guanyl-nucleotide exchange factor activity|frizzled binding|protein binding|cytoplasm|centrosome|small GTPase mediated signal transduction|microtubule binding|cell junction|PDZ domain binding|cytoskeleton-dependent intracellular transport|stress-activated protein kinase signaling cascade|cytoplasmic microtubule organization|protein destabilization|non-canonical Wnt signaling pathway|identical protein binding|protein self-association|regulation of catalytic activity|dynein light intermediate chain binding|negative regulation of canonical Wnt signaling pathway CCDC9 353.2475084 341.2557535 365.2392633 1.070280162 0.097988494 0.751085665 1 8.229639568 8.660629687 26093 coiled-coil domain containing 9 "GO:0003723,GO:0005515" RNA binding|protein binding CCDC90B 1085.262848 999.8377412 1170.687954 1.17087794 0.227590687 0.351755748 1 12.27501786 14.1320425 60492 coiled-coil domain containing 90B "GO:0005515,GO:0005739,GO:0016021,GO:0031966" protein binding|mitochondrion|integral component of membrane|mitochondrial membrane CCDC91 368.3486009 333.9728563 402.7243456 1.205859512 0.270061837 0.363470001 1 5.502784046 6.524546965 55297 coiled-coil domain containing 91 "GO:0005654,GO:0005794,GO:0005802,GO:0005829,GO:0015031,GO:0016020,GO:0042802,GO:0090160" nucleoplasm|Golgi apparatus|trans-Golgi network|cytosol|protein transport|membrane|identical protein binding|Golgi to lysosome transport CCDC92 337.6708683 336.0536841 339.2880525 1.009624559 0.013818909 0.974642941 1 3.759079329 3.731750292 80212 coiled-coil domain containing 92 "GO:0005515,GO:0005654,GO:0005737,GO:0005813,GO:0005814,GO:0042802,GO:0043231" protein binding|nucleoplasm|cytoplasm|centrosome|centriole|identical protein binding|intracellular membrane-bounded organelle CCDC93 2312.318279 2441.851383 2182.785176 0.893905826 -0.161805246 0.494119483 1 14.15721025 12.44344487 54520 coiled-coil domain containing 93 "GO:0005515,GO:0005769,GO:0006893,GO:0015031,GO:0032456,GO:0043231,GO:1990126" "protein binding|early endosome|Golgi to plasma membrane transport|protein transport|endocytic recycling|intracellular membrane-bounded organelle|retrograde transport, endosome to plasma membrane" CCDC96 33.62536721 37.45489978 29.79583464 0.795512331 -0.330043801 0.661346911 1 0.928425064 0.726214558 257236 coiled-coil domain containing 96 "GO:0005515,GO:0005930,GO:0036064,GO:0060271" protein binding|axoneme|ciliary basal body|cilium assembly CCDC97 206.3598382 219.5273292 193.1923472 0.880037797 -0.184362607 0.615373547 1 2.799467165 2.422411289 90324 coiled-coil domain containing 97 CCDC9B 1192.063787 1217.284243 1166.843331 0.958562749 -0.061055218 0.803931198 1 12.25971367 11.55505598 388115 coiled-coil domain containing 9B GO:0003723 RNA binding CCHCR1 595.4972095 544.1364606 646.8579584 1.188778928 0.249480448 0.344630198 1 8.810546973 10.29852785 54535 coiled-coil alpha-helical rod protein 1 "GO:0005515,GO:0005634,GO:0005814,GO:0005829,GO:0006611,GO:0007275,GO:0030154" protein binding|nucleus|centriole|cytosol|protein export from nucleus|multicellular organism development|cell differentiation CCIN 10.44879821 9.363724944 11.53387147 1.231761029 0.300722389 0.870906207 1 0.256663991 0.310858381 881 calicin "GO:0005515,GO:0005634,GO:0007283,GO:0007420,GO:0015629,GO:0030036,GO:0030154,GO:0032839,GO:0033150,GO:0051015" protein binding|nucleus|spermatogenesis|brain development|actin cytoskeleton|actin cytoskeleton organization|cell differentiation|dendrite cytoplasm|cytoskeletal calyx|actin filament binding CCL20 354.3225208 356.8619617 351.7830799 0.985767937 -0.020680038 0.955195919 1 22.83581177 22.13412312 6364 C-C motif chemokine ligand 20 "GO:0002548,GO:0005515,GO:0005576,GO:0005615,GO:0006935,GO:0006954,GO:0006955,GO:0007165,GO:0007186,GO:0007267,GO:0008009,GO:0019221,GO:0030593,GO:0031731,GO:0035584,GO:0042742,GO:0043547,GO:0048020,GO:0048247,GO:0060326,GO:0070098,GO:0070374,GO:0071346,GO:0071347,GO:0071356,GO:0072678,GO:0072679,GO:2000406" monocyte chemotaxis|protein binding|extracellular region|extracellular space|chemotaxis|inflammatory response|immune response|signal transduction|G protein-coupled receptor signaling pathway|cell-cell signaling|chemokine activity|cytokine-mediated signaling pathway|neutrophil chemotaxis|CCR6 chemokine receptor binding|calcium-mediated signaling using intracellular calcium source|defense response to bacterium|positive regulation of GTPase activity|CCR chemokine receptor binding|lymphocyte chemotaxis|cell chemotaxis|chemokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to tumor necrosis factor|T cell migration|thymocyte migration|positive regulation of T cell migration "hsa04060,hsa04061,hsa04062,hsa04657,hsa04668,hsa05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Rheumatoid arthritis CCL26 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.085554664 0.233143786 10344 C-C motif chemokine ligand 26 "GO:0001938,GO:0002548,GO:0005515,GO:0005615,GO:0006935,GO:0006954,GO:0007165,GO:0007186,GO:0007267,GO:0008009,GO:0010818,GO:0030335,GO:0030593,GO:0030838,GO:0031728,GO:0043547,GO:0048018,GO:0048020,GO:0048245,GO:0048247,GO:0050921,GO:0070098,GO:0070374,GO:0071346,GO:0071347,GO:0071356" positive regulation of endothelial cell proliferation|monocyte chemotaxis|protein binding|extracellular space|chemotaxis|inflammatory response|signal transduction|G protein-coupled receptor signaling pathway|cell-cell signaling|chemokine activity|T cell chemotaxis|positive regulation of cell migration|neutrophil chemotaxis|positive regulation of actin filament polymerization|CCR3 chemokine receptor binding|positive regulation of GTPase activity|receptor ligand activity|CCR chemokine receptor binding|eosinophil chemotaxis|lymphocyte chemotaxis|positive regulation of chemotaxis|chemokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to tumor necrosis factor "hsa04060,hsa04061,hsa04062" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway CCL27 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.133153421 0.362854477 10850 C-C motif chemokine ligand 27 "GO:0005515,GO:0005576,GO:0005615,GO:0006935,GO:0006955,GO:0007186,GO:0007267,GO:0008009,GO:0010820,GO:0031728,GO:0060326,GO:2000251" protein binding|extracellular region|extracellular space|chemotaxis|immune response|G protein-coupled receptor signaling pathway|cell-cell signaling|chemokine activity|positive regulation of T cell chemotaxis|CCR3 chemokine receptor binding|cell chemotaxis|positive regulation of actin cytoskeleton reorganization "hsa04060,hsa04061,hsa04062" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway CCL3 16.57742503 6.242483296 26.91236677 4.311163601 2.108077311 0.028973717 0.88444427 0.427115206 1.810550803 6348 C-C motif chemokine ligand 3 "GO:0000165,GO:0001649,GO:0001775,GO:0002548,GO:0004672,GO:0004698,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005829,GO:0006468,GO:0006816,GO:0006874,GO:0006887,GO:0006935,GO:0006954,GO:0007010,GO:0007186,GO:0007267,GO:0008009,GO:0008360,GO:0009636,GO:0010628,GO:0010629,GO:0010818,GO:0014808,GO:0016004,GO:0016301,GO:0019221,GO:0019722,GO:0023052,GO:0030335,GO:0030502,GO:0030593,GO:0031663,GO:0031726,GO:0031730,GO:0032731,GO:0032760,GO:0042056,GO:0042802,GO:0043308,GO:0043491,GO:0043525,GO:0043547,GO:0043615,GO:0043922,GO:0045671,GO:0048020,GO:0048245,GO:0048246,GO:0048247,GO:0050729,GO:0050795,GO:0050850,GO:0050918,GO:0051897,GO:0051928,GO:0051930,GO:0070098,GO:0070374,GO:0070723,GO:0071346,GO:0071347,GO:0071356,GO:0071407,GO:0071621,GO:0090280,GO:1903980,GO:1904141,GO:2000503" MAPK cascade|osteoblast differentiation|cell activation|monocyte chemotaxis|protein kinase activity|calcium-dependent protein kinase C activity|protein binding|extracellular region|extracellular space|cytoplasm|cytosol|protein phosphorylation|calcium ion transport|cellular calcium ion homeostasis|exocytosis|chemotaxis|inflammatory response|cytoskeleton organization|G protein-coupled receptor signaling pathway|cell-cell signaling|chemokine activity|regulation of cell shape|response to toxic substance|positive regulation of gene expression|negative regulation of gene expression|T cell chemotaxis|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|phospholipase activator activity|kinase activity|cytokine-mediated signaling pathway|calcium-mediated signaling|signaling|positive regulation of cell migration|negative regulation of bone mineralization|neutrophil chemotaxis|lipopolysaccharide-mediated signaling pathway|CCR1 chemokine receptor binding|CCR5 chemokine receptor binding|positive regulation of interleukin-1 beta production|positive regulation of tumor necrosis factor production|chemoattractant activity|identical protein binding|eosinophil degranulation|protein kinase B signaling|positive regulation of neuron apoptotic process|positive regulation of GTPase activity|astrocyte cell migration|negative regulation by host of viral transcription|negative regulation of osteoclast differentiation|CCR chemokine receptor binding|eosinophil chemotaxis|macrophage chemotaxis|lymphocyte chemotaxis|positive regulation of inflammatory response|regulation of behavior|positive regulation of calcium-mediated signaling|positive chemotaxis|positive regulation of protein kinase B signaling|positive regulation of calcium ion transport|regulation of sensory perception of pain|chemokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|response to cholesterol|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to organic cyclic compound|granulocyte chemotaxis|positive regulation of calcium ion import|positive regulation of microglial cell activation|positive regulation of microglial cell migration|positive regulation of natural killer cell chemotaxis "hsa04060,hsa04061,hsa04062,hsa04620,hsa05142,hsa05163,hsa05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|Toll-like receptor signaling pathway|Chagas disease|Human cytomegalovirus infection|Rheumatoid arthritis CCM2 986.0366858 867.7051781 1104.368193 1.272745883 0.347944399 0.157551392 1 14.46215821 18.09864192 83605 CCM2 scaffold protein "GO:0001570,GO:0001701,GO:0001885,GO:0005515,GO:0005737,GO:0005739,GO:0007229,GO:0032991,GO:0035264,GO:0045216,GO:0048839,GO:0048845,GO:0051403,GO:0060039,GO:0060837,GO:0061154" vasculogenesis|in utero embryonic development|endothelial cell development|protein binding|cytoplasm|mitochondrion|integrin-mediated signaling pathway|protein-containing complex|multicellular organism growth|cell-cell junction organization|inner ear development|venous blood vessel morphogenesis|stress-activated MAPK cascade|pericardium development|blood vessel endothelial cell differentiation|endothelial tube morphogenesis CCN1 16455.92106 13890.56575 19021.27637 1.36936657 0.453508698 0.088372119 1 325.4231625 438.1666923 3491 cellular communication network factor 1 "GO:0001649,GO:0001934,GO:0002041,GO:0003181,GO:0003278,GO:0003281,GO:0005178,GO:0005201,GO:0005515,GO:0005520,GO:0005788,GO:0006935,GO:0007155,GO:0007165,GO:0008201,GO:0010518,GO:0010811,GO:0030198,GO:0030335,GO:0030501,GO:0030513,GO:0031012,GO:0033690,GO:0043065,GO:0043066,GO:0043280,GO:0043687,GO:0044267,GO:0044319,GO:0045669,GO:0045860,GO:0045944,GO:0050840,GO:0060413,GO:0060548,GO:0060591,GO:0060710,GO:0060716,GO:0061036,GO:0062023,GO:0070372,GO:0072593,GO:2000304" "osteoblast differentiation|positive regulation of protein phosphorylation|intussusceptive angiogenesis|atrioventricular valve morphogenesis|apoptotic process involved in heart morphogenesis|ventricular septum development|integrin binding|extracellular matrix structural constituent|protein binding|insulin-like growth factor binding|endoplasmic reticulum lumen|chemotaxis|cell adhesion|signal transduction|heparin binding|positive regulation of phospholipase activity|positive regulation of cell-substrate adhesion|extracellular matrix organization|positive regulation of cell migration|positive regulation of bone mineralization|positive regulation of BMP signaling pathway|extracellular matrix|positive regulation of osteoblast proliferation|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|post-translational protein modification|cellular protein metabolic process|wound healing, spreading of cells|positive regulation of osteoblast differentiation|positive regulation of protein kinase activity|positive regulation of transcription by RNA polymerase II|extracellular matrix binding|atrial septum morphogenesis|negative regulation of cell death|chondroblast differentiation|chorio-allantoic fusion|labyrinthine layer blood vessel development|positive regulation of cartilage development|collagen-containing extracellular matrix|regulation of ERK1 and ERK2 cascade|reactive oxygen species metabolic process|positive regulation of ceramide biosynthetic process" CCN2 3558.589726 2609.358018 4507.821434 1.727559577 0.788735465 0.000948726 0.194410378 59.56229324 101.1755613 1490 cellular communication network factor 2 "GO:0001502,GO:0001503,GO:0001525,GO:0001894,GO:0001934,GO:0001968,GO:0005178,GO:0005515,GO:0005520,GO:0005576,GO:0005615,GO:0005801,GO:0005829,GO:0005886,GO:0005938,GO:0006367,GO:0007155,GO:0007160,GO:0007165,GO:0007229,GO:0007568,GO:0008022,GO:0008083,GO:0008201,GO:0008284,GO:0008543,GO:0008544,GO:0009611,GO:0009749,GO:0010628,GO:0010629,GO:0010942,GO:0016477,GO:0030154,GO:0030324,GO:0031012,GO:0032330,GO:0032355,GO:0032967,GO:0034059,GO:0035556,GO:0035988,GO:0043200,GO:0043280,GO:0043434,GO:0045597,GO:0046330,GO:0048471,GO:0050867,GO:0051385,GO:0051496,GO:0060401,GO:0060452,GO:0060548,GO:0062023,GO:0070278,GO:0070318,GO:0070374,GO:0070542,GO:0071897,GO:0072593" cartilage condensation|ossification|angiogenesis|tissue homeostasis|positive regulation of protein phosphorylation|fibronectin binding|integrin binding|protein binding|insulin-like growth factor binding|extracellular region|extracellular space|cis-Golgi network|cytosol|plasma membrane|cell cortex|transcription initiation from RNA polymerase II promoter|cell adhesion|cell-matrix adhesion|signal transduction|integrin-mediated signaling pathway|aging|protein C-terminus binding|growth factor activity|heparin binding|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|epidermis development|response to wounding|response to glucose|positive regulation of gene expression|negative regulation of gene expression|positive regulation of cell death|cell migration|cell differentiation|lung development|extracellular matrix|regulation of chondrocyte differentiation|response to estradiol|positive regulation of collagen biosynthetic process|response to anoxia|intracellular signal transduction|chondrocyte proliferation|response to amino acid|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|response to peptide hormone|positive regulation of cell differentiation|positive regulation of JNK cascade|perinuclear region of cytoplasm|positive regulation of cell activation|response to mineralocorticoid|positive regulation of stress fiber assembly|cytosolic calcium ion transport|positive regulation of cardiac muscle contraction|negative regulation of cell death|collagen-containing extracellular matrix|extracellular matrix constituent secretion|positive regulation of G0 to G1 transition|positive regulation of ERK1 and ERK2 cascade|response to fatty acid|DNA biosynthetic process|reactive oxygen species metabolic process "hsa04371,hsa04390" Apelin signaling pathway|Hippo signaling pathway CCN3 35.66153559 53.06110801 18.26196316 0.344168523 -1.538812938 0.025306551 0.865167718 1.149725462 0.389077822 4856 cellular communication network factor 3 "GO:0001525,GO:0002062,GO:0005112,GO:0005178,GO:0005515,GO:0005520,GO:0005576,GO:0005737,GO:0005921,GO:0007155,GO:0007165,GO:0008083,GO:0008201,GO:0010468,GO:0010761,GO:0010832,GO:0014909,GO:0030308,GO:0030424,GO:0030425,GO:0031012,GO:0033627,GO:0035767,GO:0043025,GO:0043231,GO:0044342,GO:0045747,GO:0046676,GO:0048659,GO:0050728,GO:0060326,GO:0060392,GO:0060548,GO:0061484,GO:0062023,GO:0071603,GO:0090027,GO:1901223,GO:1902731,GO:1904057,GO:1990523" angiogenesis|chondrocyte differentiation|Notch binding|integrin binding|protein binding|insulin-like growth factor binding|extracellular region|cytoplasm|gap junction|cell adhesion|signal transduction|growth factor activity|heparin binding|regulation of gene expression|fibroblast migration|negative regulation of myotube differentiation|smooth muscle cell migration|negative regulation of cell growth|axon|dendrite|extracellular matrix|cell adhesion mediated by integrin|endothelial cell chemotaxis|neuronal cell body|intracellular membrane-bounded organelle|type B pancreatic cell proliferation|positive regulation of Notch signaling pathway|negative regulation of insulin secretion|smooth muscle cell proliferation|negative regulation of inflammatory response|cell chemotaxis|negative regulation of SMAD protein signal transduction|negative regulation of cell death|hematopoietic stem cell homeostasis|collagen-containing extracellular matrix|endothelial cell-cell adhesion|negative regulation of monocyte chemotaxis|negative regulation of NIK/NF-kappaB signaling|negative regulation of chondrocyte proliferation|negative regulation of sensory perception of pain|bone regeneration CCNA1 108.0206046 72.82897178 143.2122374 1.9664185 0.975570394 0.032853907 0.920517339 1.182460715 2.286303341 8900 cyclin A1 "GO:0000079,GO:0000083,GO:0000307,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007141,GO:0007283,GO:0015630,GO:0016538,GO:0016579,GO:0044772,GO:0051301,GO:0097123,GO:0097124" regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of transcription involved in G1/S transition of mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|male meiosis I|spermatogenesis|microtubule cytoskeleton|cyclin-dependent protein serine/threonine kinase regulator activity|protein deubiquitination|mitotic cell cycle phase transition|cell division|cyclin A1-CDK2 complex|cyclin A2-CDK2 complex "hsa04110,hsa04152,hsa04218,hsa04914,hsa05161,hsa05165,hsa05166,hsa05169,hsa05200,hsa05202,hsa05203,hsa05221" Cell cycle|AMPK signaling pathway|Cellular senescence|Progesterone-mediated oocyte maturation|Hepatitis B|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Acute myeloid leukemia CCNA2 2252.712748 2277.465989 2227.959506 0.978262471 -0.031706498 0.895123791 1 44.23004877 42.54455543 890 cyclin A2 "GO:0000079,GO:0000086,GO:0000307,GO:0001939,GO:0001940,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006275,GO:0007265,GO:0016032,GO:0016538,GO:0016572,GO:0016579,GO:0019901,GO:0019904,GO:0031100,GO:0033762,GO:0036120,GO:0044320,GO:0044772,GO:0044843,GO:0045893,GO:0048146,GO:0051301,GO:0071314,GO:0071373,GO:0071392,GO:0071456,GO:0071732,GO:0090102,GO:0097124,GO:1990314" "regulation of cyclin-dependent protein serine/threonine kinase activity|G2/M transition of mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|female pronucleus|male pronucleus|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of DNA replication|Ras protein signal transduction|viral process|cyclin-dependent protein serine/threonine kinase regulator activity|histone phosphorylation|protein deubiquitination|protein kinase binding|protein domain specific binding|animal organ regeneration|response to glucagon|cellular response to platelet-derived growth factor stimulus|cellular response to leptin stimulus|mitotic cell cycle phase transition|cell cycle G1/S phase transition|positive regulation of transcription, DNA-templated|positive regulation of fibroblast proliferation|cell division|cellular response to cocaine|cellular response to luteinizing hormone stimulus|cellular response to estradiol stimulus|cellular response to hypoxia|cellular response to nitric oxide|cochlea development|cyclin A2-CDK2 complex|cellular response to insulin-like growth factor stimulus" "hsa04110,hsa04152,hsa04218,hsa04914,hsa05161,hsa05165,hsa05166,hsa05169,hsa05200,hsa05202,hsa05203,hsa05221" Cell cycle|AMPK signaling pathway|Cellular senescence|Progesterone-mediated oocyte maturation|Hepatitis B|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Acute myeloid leukemia CCNB1 4486.957169 4271.939402 4701.974937 1.100665177 0.138375667 0.56294398 1 112.3635064 121.6050717 891 cyclin B1 "GO:0000079,GO:0000086,GO:0000307,GO:0000922,GO:0000942,GO:0001556,GO:0001701,GO:0001933,GO:0005113,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005759,GO:0005813,GO:0005829,GO:0006367,GO:0006977,GO:0007052,GO:0007077,GO:0007080,GO:0007283,GO:0009612,GO:0010629,GO:0010971,GO:0016020,GO:0016538,GO:0019901,GO:0031145,GO:0031442,GO:0033129,GO:0042246,GO:0042493,GO:0044389,GO:0044772,GO:0045737,GO:0045931,GO:0046680,GO:0048146,GO:0048565,GO:0051301,GO:0051726,GO:0051987,GO:0055015,GO:0060045,GO:0060623,GO:0061575,GO:0065003,GO:0071283,GO:0071398,GO:0071407,GO:0071456,GO:0090266,GO:0097125,GO:1901990,GO:1905448,GO:2000775" "regulation of cyclin-dependent protein serine/threonine kinase activity|G2/M transition of mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|spindle pole|condensed nuclear chromosome outer kinetochore|oocyte maturation|in utero embryonic development|negative regulation of protein phosphorylation|patched binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrial matrix|centrosome|cytosol|transcription initiation from RNA polymerase II promoter|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|mitotic spindle organization|mitotic nuclear envelope disassembly|mitotic metaphase plate congression|spermatogenesis|response to mechanical stimulus|negative regulation of gene expression|positive regulation of G2/M transition of mitotic cell cycle|membrane|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|anaphase-promoting complex-dependent catabolic process|positive regulation of mRNA 3'-end processing|positive regulation of histone phosphorylation|tissue regeneration|response to drug|ubiquitin-like protein ligase binding|mitotic cell cycle phase transition|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of mitotic cell cycle|response to DDT|positive regulation of fibroblast proliferation|digestive tract development|cell division|regulation of cell cycle|positive regulation of attachment of spindle microtubules to kinetochore|ventricular cardiac muscle cell development|positive regulation of cardiac muscle cell proliferation|regulation of chromosome condensation|cyclin-dependent protein serine/threonine kinase activator activity|protein-containing complex assembly|cellular response to iron(III) ion|cellular response to fatty acid|cellular response to organic cyclic compound|cellular response to hypoxia|regulation of mitotic cell cycle spindle assembly checkpoint|cyclin B1-CDK1 complex|regulation of mitotic cell cycle phase transition|positive regulation of mitochondrial ATP synthesis coupled electron transport|histone H3-S10 phosphorylation involved in chromosome condensation" "hsa04068,hsa04110,hsa04114,hsa04115,hsa04218,hsa04914,hsa05170" FoxO signaling pathway|Cell cycle|Oocyte meiosis|p53 signaling pathway|Cellular senescence|Progesterone-mediated oocyte maturation|Human immunodeficiency virus 1 infection CCNB1IP1 1428.342762 1528.367994 1328.317531 0.869108446 -0.20239189 0.398096034 1 49.40411314 42.21903053 57820 cyclin B1 interacting protein 1 "GO:0000795,GO:0005515,GO:0007131,GO:0016567,GO:0042802,GO:0046872,GO:0051026,GO:0061630" synaptonemal complex|protein binding|reciprocal meiotic recombination|protein ubiquitination|identical protein binding|metal ion binding|chiasma assembly|ubiquitin protein ligase activity CCNB2 1785.553781 1872.744989 1698.362574 0.906884058 -0.141009977 0.553004493 1 67.16731054 59.89366718 9133 cyclin B2 "GO:0000079,GO:0000086,GO:0000307,GO:0001701,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0007057,GO:0007077,GO:0008315,GO:0015630,GO:0016020,GO:0016538,GO:0040008,GO:0043029,GO:0044772,GO:0045296,GO:0048538,GO:0051301,GO:0051726" regulation of cyclin-dependent protein serine/threonine kinase activity|G2/M transition of mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|in utero embryonic development|protein binding|nucleus|cytoplasm|centrosome|cytosol|spindle assembly involved in female meiosis I|mitotic nuclear envelope disassembly|G2/MI transition of meiotic cell cycle|microtubule cytoskeleton|membrane|cyclin-dependent protein serine/threonine kinase regulator activity|regulation of growth|T cell homeostasis|mitotic cell cycle phase transition|cadherin binding|thymus development|cell division|regulation of cell cycle "hsa04068,hsa04110,hsa04114,hsa04115,hsa04218,hsa04914,hsa05166,hsa05170" FoxO signaling pathway|Cell cycle|Oocyte meiosis|p53 signaling pathway|Cellular senescence|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection CCNB3 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.04492312 0.020403225 85417 cyclin B3 "GO:0000079,GO:0000307,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0010389,GO:0016538,GO:0016607,GO:0019901,GO:0044772,GO:0051301,GO:0051321" regulation of cyclin-dependent protein serine/threonine kinase activity|cyclin-dependent protein kinase holoenzyme complex|protein binding|nucleus|cytoplasm|centrosome|regulation of G2/M transition of mitotic cell cycle|cyclin-dependent protein serine/threonine kinase regulator activity|nuclear speck|protein kinase binding|mitotic cell cycle phase transition|cell division|meiotic cell cycle "hsa04068,hsa04110,hsa04218,hsa04914,hsa05170" FoxO signaling pathway|Cell cycle|Cellular senescence|Progesterone-mediated oocyte maturation|Human immunodeficiency virus 1 infection CCNC 858.684136 766.7850315 950.5832405 1.239699787 0.309990792 0.214434663 1 15.24093402 18.5780141 892 cyclin C "GO:0000079,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006367,GO:0016538,GO:0016592,GO:0042802,GO:0045944" regulation of cyclin-dependent protein serine/threonine kinase activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|cyclin-dependent protein serine/threonine kinase regulator activity|mediator complex|identical protein binding|positive regulation of transcription by RNA polymerase II CCND1 10185.03021 10185.65191 10184.40851 0.999877926 -0.000176126 0.999886062 1 128.2655786 126.103832 595 cyclin D1 "GO:0000079,GO:0000082,GO:0000122,GO:0000307,GO:0000320,GO:0001934,GO:0003714,GO:0004672,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005923,GO:0006367,GO:0006468,GO:0006974,GO:0007595,GO:0008134,GO:0010039,GO:0010165,GO:0010243,GO:0010971,GO:0016055,GO:0016538,GO:0017053,GO:0019221,GO:0019899,GO:0019901,GO:0030857,GO:0030968,GO:0031571,GO:0031965,GO:0032026,GO:0032355,GO:0033197,GO:0033327,GO:0033598,GO:0033601,GO:0042493,GO:0042826,GO:0043627,GO:0044321,GO:0044772,GO:0044877,GO:0045444,GO:0045471,GO:0045737,GO:0045787,GO:0051301,GO:0051412,GO:0051592,GO:0060749,GO:0070064,GO:0070141,GO:0071157,GO:0097421,GO:1900087" regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|cyclin-dependent protein kinase holoenzyme complex|re-entry into mitotic cell cycle|positive regulation of protein phosphorylation|transcription corepressor activity|protein kinase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|bicellular tight junction|transcription initiation from RNA polymerase II promoter|protein phosphorylation|cellular response to DNA damage stimulus|lactation|transcription factor binding|response to iron ion|response to X-ray|response to organonitrogen compound|positive regulation of G2/M transition of mitotic cell cycle|Wnt signaling pathway|cyclin-dependent protein serine/threonine kinase regulator activity|transcription repressor complex|cytokine-mediated signaling pathway|enzyme binding|protein kinase binding|negative regulation of epithelial cell differentiation|endoplasmic reticulum unfolded protein response|mitotic G1 DNA damage checkpoint|nuclear membrane|response to magnesium ion|response to estradiol|response to vitamin E|Leydig cell differentiation|mammary gland epithelial cell proliferation|positive regulation of mammary gland epithelial cell proliferation|response to drug|histone deacetylase binding|response to estrogen|response to leptin|mitotic cell cycle phase transition|protein-containing complex binding|fat cell differentiation|response to ethanol|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of cell cycle|cell division|response to corticosterone|response to calcium ion|mammary gland alveolus development|proline-rich region binding|response to UV-A|negative regulation of cell cycle arrest|liver regeneration|positive regulation of G1/S transition of mitotic cell cycle "hsa01522,hsa04068,hsa04110,hsa04115,hsa04151,hsa04152,hsa04218,hsa04310,hsa04340,hsa04371,hsa04390,hsa04510,hsa04530,hsa04630,hsa04917,hsa04919,hsa04921,hsa04933,hsa04934,hsa05160,hsa05162,hsa05163,hsa05165,hsa05166,hsa05167,hsa05169,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05416" Endocrine resistance|FoxO signaling pathway|Cell cycle|p53 signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Cellular senescence|Wnt signaling pathway|Hedgehog signaling pathway|Apelin signaling pathway|Hippo signaling pathway|Focal adhesion|Tight junction|JAK-STAT signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Hepatitis C|Measles|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Viral myocarditis CCND3 1213.636304 1051.858435 1375.414173 1.307603882 0.386925565 0.109774619 1 19.25754767 24.75987007 896 cyclin D3 "GO:0000079,GO:0000122,GO:0000307,GO:0001934,GO:0004693,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007165,GO:0016020,GO:0016538,GO:0019901,GO:0042098,GO:0042127,GO:0044772,GO:0045737,GO:0046626,GO:0051301,GO:1900087" regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription by RNA polymerase II|cyclin-dependent protein kinase holoenzyme complex|positive regulation of protein phosphorylation|cyclin-dependent protein serine/threonine kinase activity|protein binding|nucleus|nucleoplasm|cytoplasm|signal transduction|membrane|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|T cell proliferation|regulation of cell population proliferation|mitotic cell cycle phase transition|positive regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of insulin receptor signaling pathway|cell division|positive regulation of G1/S transition of mitotic cell cycle "hsa04110,hsa04115,hsa04151,hsa04218,hsa04310,hsa04390,hsa04510,hsa04630,hsa05162,hsa05164,hsa05165,hsa05166,hsa05169,hsa05200,hsa05203" Cell cycle|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Wnt signaling pathway|Hippo signaling pathway|Focal adhesion|JAK-STAT signaling pathway|Measles|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis CCNDBP1 915.9817414 794.8762063 1037.087277 1.304715462 0.383735212 0.121658793 1 11.42809327 14.66090447 23582 cyclin D1 binding protein 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007049,GO:0016604,GO:0051726" protein binding|nucleus|nucleoplasm|cytoplasm|cell cycle|nuclear body|regulation of cell cycle CCNE1 249.3740824 213.2848459 285.4633189 1.338413508 0.420523911 0.210512484 1 5.825291825 7.666182902 898 cyclin E1 "GO:0000079,GO:0000082,GO:0000083,GO:0000122,GO:0000307,GO:0000723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006270,GO:0006468,GO:0007129,GO:0016055,GO:0016301,GO:0016538,GO:0019901,GO:0044772,GO:0051301,GO:0097134,GO:1902462,GO:1903827" regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|cyclin-dependent protein kinase holoenzyme complex|telomere maintenance|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|DNA replication initiation|protein phosphorylation|homologous chromosome pairing at meiosis|Wnt signaling pathway|kinase activity|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|mitotic cell cycle phase transition|cell division|cyclin E1-CDK2 complex|positive regulation of mesenchymal stem cell proliferation|regulation of cellular protein localization "hsa04110,hsa04114,hsa04115,hsa04151,hsa04218,hsa04934,hsa05161,hsa05162,hsa05165,hsa05166,hsa05169,hsa05200,hsa05203,hsa05206,hsa05215,hsa05222,hsa05226" Cell cycle|Oocyte meiosis|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Cushing syndrome|Hepatitis B|Measles|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|MicroRNAs in cancer|Prostate cancer|Small cell lung cancer|Gastric cancer CCNE2 628.032473 603.4400519 652.6248941 1.081507421 0.113043564 0.668673889 1 8.426082286 8.960378973 9134 cyclin E2 "GO:0000079,GO:0000082,GO:0000307,GO:0000723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006270,GO:0007129,GO:0016538,GO:0019901,GO:0044772,GO:0051301,GO:0097134,GO:0097135,GO:1903827" regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|telomere maintenance|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|DNA replication initiation|homologous chromosome pairing at meiosis|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|mitotic cell cycle phase transition|cell division|cyclin E1-CDK2 complex|cyclin E2-CDK2 complex|regulation of cellular protein localization "hsa04110,hsa04114,hsa04115,hsa04151,hsa04218,hsa04934,hsa05161,hsa05162,hsa05165,hsa05166,hsa05169,hsa05200,hsa05203,hsa05206,hsa05215,hsa05222,hsa05226" Cell cycle|Oocyte meiosis|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Cushing syndrome|Hepatitis B|Measles|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|MicroRNAs in cancer|Prostate cancer|Small cell lung cancer|Gastric cancer CCNF 745.1878609 865.6243504 624.7513714 0.721734978 -0.47045892 0.06382012 1 10.92122473 7.75033145 899 cyclin F "GO:0000079,GO:0000209,GO:0000307,GO:0000320,GO:0001890,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0010826,GO:0016538,GO:0016567,GO:0019005,GO:0030054,GO:0031146,GO:0043687,GO:0044772,GO:0051301" regulation of cyclin-dependent protein serine/threonine kinase activity|protein polyubiquitination|cyclin-dependent protein kinase holoenzyme complex|re-entry into mitotic cell cycle|placenta development|protein binding|nucleus|cytoplasm|centrosome|centriole|cytosol|negative regulation of centrosome duplication|cyclin-dependent protein serine/threonine kinase regulator activity|protein ubiquitination|SCF ubiquitin ligase complex|cell junction|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|mitotic cell cycle phase transition|cell division CCNG1 6084.538222 5713.953043 6455.1234 1.129712364 0.175955495 0.467936615 1 128.7766774 143.0461838 900 cyclin G1 "GO:0000079,GO:0000307,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0016538,GO:0044772,GO:0051301" regulation of cyclin-dependent protein serine/threonine kinase activity|cyclin-dependent protein kinase holoenzyme complex|protein binding|nucleus|nucleoplasm|cytoplasm|cyclin-dependent protein serine/threonine kinase regulator activity|mitotic cell cycle phase transition|cell division "hsa04115,hsa05206" p53 signaling pathway|MicroRNAs in cancer CCNG2 893.4380071 985.2719469 801.6040673 0.813586614 -0.297632152 0.231165157 1 17.01137268 13.60862768 901 cyclin G2 "GO:0000079,GO:0000307,GO:0005634,GO:0005737,GO:0016538,GO:0044772,GO:0051301" regulation of cyclin-dependent protein serine/threonine kinase activity|cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm|cyclin-dependent protein serine/threonine kinase regulator activity|mitotic cell cycle phase transition|cell division "hsa04068,hsa04115" FoxO signaling pathway|p53 signaling pathway CCNH 1470.501489 1259.941212 1681.061767 1.334238257 0.416016314 0.081684582 1 9.992680458 13.10951328 902 cyclin H "GO:0000079,GO:0000082,GO:0000086,GO:0000439,GO:0005515,GO:0005634,GO:0005654,GO:0005675,GO:0006283,GO:0006294,GO:0006357,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0016251,GO:0016538,GO:0019907,GO:0050821,GO:0070516,GO:0070816,GO:0070985" "regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|transcription factor TFIIH core complex|protein binding|nucleus|nucleoplasm|transcription factor TFIIH holo complex|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|RNA polymerase II general transcription initiation factor activity|cyclin-dependent protein serine/threonine kinase regulator activity|cyclin-dependent protein kinase activating kinase holoenzyme complex|protein stabilization|CAK-ERCC2 complex|phosphorylation of RNA polymerase II C-terminal domain|transcription factor TFIIK complex" "hsa03022,hsa03420,hsa04110" Basal transcription factors|Nucleotide excision repair|Cell cycle CCNI 6145.312501 5959.49072 6331.134282 1.062361631 0.087274948 0.719281418 1 110.4330092 115.356604 10983 cyclin I "GO:0000079,GO:0000307,GO:0005515,GO:0005634,GO:0005737,GO:0007283,GO:0016538,GO:0031965,GO:0044772" regulation of cyclin-dependent protein serine/threonine kinase activity|cyclin-dependent protein kinase holoenzyme complex|protein binding|nucleus|cytoplasm|spermatogenesis|cyclin-dependent protein serine/threonine kinase regulator activity|nuclear membrane|mitotic cell cycle phase transition CCNJ 547.7268753 526.4494246 569.0043259 1.080833788 0.112144681 0.680052857 1 6.671963481 7.0906125 54619 cyclin J "GO:0000079,GO:0000307,GO:0005634,GO:0005737,GO:0005813,GO:0016538,GO:0044772" regulation of cyclin-dependent protein serine/threonine kinase activity|cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm|centrosome|cyclin-dependent protein serine/threonine kinase regulator activity|mitotic cell cycle phase transition CCNJL 297.3469775 324.6091314 270.0848236 0.832030887 -0.265291009 0.403007114 1 2.209103894 1.807285518 79616 cyclin J like "GO:0000079,GO:0000307,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0016538,GO:0044772" regulation of cyclin-dependent protein serine/threonine kinase activity|cyclin-dependent protein kinase holoenzyme complex|protein binding|nucleus|cytoplasm|centrosome|cyclin-dependent protein serine/threonine kinase regulator activity|mitotic cell cycle phase transition CCNK 1417.919731 1355.659289 1480.180172 1.091852639 0.126778157 0.597797505 1 24.93934666 26.77443276 8812 cyclin K "GO:0000079,GO:0002944,GO:0002945,GO:0004693,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006366,GO:0006368,GO:0006468,GO:0006974,GO:0007049,GO:0008024,GO:0008353,GO:0016538,GO:0019901,GO:0032786,GO:0042795,GO:0044828,GO:0045737,GO:0045944,GO:0051301,GO:0061575,GO:2001165" "regulation of cyclin-dependent protein serine/threonine kinase activity|cyclin K-CDK12 complex|cyclin K-CDK13 complex|cyclin-dependent protein serine/threonine kinase activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|protein phosphorylation|cellular response to DNA damage stimulus|cell cycle|cyclin/CDK positive transcription elongation factor complex|RNA polymerase II CTD heptapeptide repeat kinase activity|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|positive regulation of DNA-templated transcription, elongation|snRNA transcription by RNA polymerase II|negative regulation by host of viral genome replication|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription by RNA polymerase II|cell division|cyclin-dependent protein serine/threonine kinase activator activity|positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues" CCNL1 1893.678182 1986.150102 1801.206262 0.906883251 -0.14101126 0.552415577 1 16.4336714 14.65403278 57018 cyclin L1 "GO:0000079,GO:0005515,GO:0005634,GO:0006357,GO:0006396,GO:0016538,GO:0016607" regulation of cyclin-dependent protein serine/threonine kinase activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|RNA processing|cyclin-dependent protein serine/threonine kinase regulator activity|nuclear speck CCNL2 2703.976199 2971.422049 2436.530348 0.819987975 -0.286325342 0.226014125 1 31.40184822 25.31826098 81669 cyclin L2 "GO:0000079,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0016538,GO:0016607,GO:0043231" regulation of cyclin-dependent protein serine/threonine kinase activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cyclin-dependent protein serine/threonine kinase regulator activity|nuclear speck|intracellular membrane-bounded organelle CCNO 131.6330922 112.3646993 150.9014851 1.342961677 0.425418137 0.320126302 1 4.406096609 5.818202249 10309 cyclin O "GO:0000079,GO:0000278,GO:0000307,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0016538,GO:0042493,GO:0044772,GO:0051301,GO:0060271,GO:0097124,GO:1903251" regulation of cyclin-dependent protein serine/threonine kinase activity|mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|protein binding|nucleus|nucleolus|cytoplasm|cyclin-dependent protein serine/threonine kinase regulator activity|response to drug|mitotic cell cycle phase transition|cell division|cilium assembly|cyclin A2-CDK2 complex|multi-ciliated epithelial cell differentiation CCNP 10.16636505 14.56579436 5.766935736 0.395923188 -1.336707531 0.252942837 1 0.428055988 0.166641318 79935 cyclin P "GO:0000079,GO:0000307,GO:0005634,GO:0005737,GO:0016538,GO:0044772,GO:0097124" regulation of cyclin-dependent protein serine/threonine kinase activity|cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm|cyclin-dependent protein serine/threonine kinase regulator activity|mitotic cell cycle phase transition|cyclin A2-CDK2 complex CCNQ 460.3019266 426.5696919 494.0341614 1.158155797 0.21182934 0.449946953 1 8.759230648 9.974798382 92002 cyclin Q "GO:0000079,GO:0005515,GO:0005634,GO:0006357,GO:0016538" regulation of cyclin-dependent protein serine/threonine kinase activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|cyclin-dependent protein serine/threonine kinase regulator activity CCNT1 1509.981882 1476.347299 1543.616465 1.045564594 0.064282194 0.789851519 1 11.47872115 11.80091148 904 cyclin T1 "GO:0000079,GO:0000976,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0006366,GO:0006368,GO:0006468,GO:0007049,GO:0008024,GO:0008134,GO:0016032,GO:0016538,GO:0019901,GO:0032786,GO:0042795,GO:0043923,GO:0045737,GO:0045944,GO:0050434,GO:0051301,GO:0061575,GO:0070063,GO:0070691,GO:0097322,GO:1900364" "regulation of cyclin-dependent protein serine/threonine kinase activity|transcription regulatory region sequence-specific DNA binding|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|protein phosphorylation|cell cycle|cyclin/CDK positive transcription elongation factor complex|transcription factor binding|viral process|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|positive regulation of DNA-templated transcription, elongation|snRNA transcription by RNA polymerase II|positive regulation by host of viral transcription|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription by RNA polymerase II|positive regulation of viral transcription|cell division|cyclin-dependent protein serine/threonine kinase activator activity|RNA polymerase binding|P-TEFb complex|7SK snRNA binding|negative regulation of mRNA polyadenylation" hsa05202 Transcriptional misregulation in cancer CCNT2 983.3752861 1012.322708 954.4278643 0.942809893 -0.084961197 0.733051777 1 6.385273886 5.919361181 905 cyclin T2 "GO:0000079,GO:0001223,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006357,GO:0006366,GO:0006368,GO:0007049,GO:0007519,GO:0008024,GO:0016538,GO:0019085,GO:0019086,GO:0032786,GO:0042795,GO:0045737,GO:0045944,GO:0048471,GO:0051301,GO:0061575,GO:0070063,GO:0097322" "regulation of cyclin-dependent protein serine/threonine kinase activity|transcription coactivator binding|chromatin binding|protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|cell cycle|skeletal muscle tissue development|cyclin/CDK positive transcription elongation factor complex|cyclin-dependent protein serine/threonine kinase regulator activity|early viral transcription|late viral transcription|positive regulation of DNA-templated transcription, elongation|snRNA transcription by RNA polymerase II|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|cell division|cyclin-dependent protein serine/threonine kinase activator activity|RNA polymerase binding|7SK snRNA binding" hsa05202 Transcriptional misregulation in cancer other CCNY 885.8286317 886.432628 885.2246355 0.998637243 -0.001967384 0.998908206 1 8.688205723 8.531178576 219771 cyclin Y "GO:0000086,GO:0000308,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0016055,GO:0016538,GO:0019901,GO:0045737,GO:0051301,GO:0060828" G2/M transition of mitotic cell cycle|cytoplasmic cyclin-dependent protein kinase holoenzyme complex|protein binding|nucleus|cytoplasm|plasma membrane|Wnt signaling pathway|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|positive regulation of cyclin-dependent protein serine/threonine kinase activity|cell division|regulation of canonical Wnt signaling pathway CCNYL1 735.1359667 765.7446176 704.5273157 0.920055198 -0.120207678 0.63973126 1 11.47609741 10.38195848 151195 cyclin Y like 1 "GO:0005515,GO:0005737,GO:0005886,GO:0007283,GO:0016538,GO:0019901,GO:0030317,GO:0045737" protein binding|cytoplasm|plasma membrane|spermatogenesis|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|flagellated sperm motility|positive regulation of cyclin-dependent protein serine/threonine kinase activity CCP110 714.5258338 729.3301317 699.721536 0.959403027 -0.059791104 0.819776773 1 7.712107921 7.275207109 9738 centriolar coiled-coil protein 110 "GO:0000086,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0005929,GO:0007099,GO:0010389,GO:0016579,GO:0032053,GO:0032465,GO:0032991,GO:0045724,GO:0051298,GO:0097711,GO:1902018,GO:1903723" G2/M transition of mitotic cell cycle|protein binding|centrosome|centriole|cytosol|cilium|centriole replication|regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|ciliary basal body organization|regulation of cytokinesis|protein-containing complex|positive regulation of cilium assembly|centrosome duplication|ciliary basal body-plasma membrane docking|negative regulation of cilium assembly|negative regulation of centriole elongation CCPG1 1237.808013 1194.395137 1281.220889 1.072694328 0.101239029 0.677252157 1 9.033825577 9.528375504 9236 cell cycle progression 1 "GO:0003674,GO:0005515,GO:0007049,GO:0008284,GO:0016020,GO:0016021,GO:0045787,GO:0045944,GO:2001106" molecular_function|protein binding|cell cycle|positive regulation of cell population proliferation|membrane|integral component of membrane|positive regulation of cell cycle|positive regulation of transcription by RNA polymerase II|regulation of Rho guanyl-nucleotide exchange factor activity CCR10 52.48176482 53.06110801 51.90242162 0.97816317 -0.03185295 0.993753559 1 1.597165151 1.536145351 2826 C-C motif chemokine receptor 10 "GO:0004930,GO:0005515,GO:0005783,GO:0005886,GO:0005887,GO:0006955,GO:0007186,GO:0007204,GO:0009897,GO:0009986,GO:0016493,GO:0019722,GO:0019957,GO:0060326,GO:0070098" G protein-coupled receptor activity|protein binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|immune response|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|external side of plasma membrane|cell surface|C-C chemokine receptor activity|calcium-mediated signaling|C-C chemokine binding|cell chemotaxis|chemokine-mediated signaling pathway "hsa04060,hsa04061,hsa04062,hsa04672" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|Intestinal immune network for IgA production CCRL2 22.85953729 19.76786377 25.95121081 1.312797939 0.392644879 0.661199075 1 0.565064037 0.729401636 9034 C-C motif chemokine receptor like 2 "GO:0004950,GO:0005737,GO:0005886,GO:0005887,GO:0006935,GO:0006954,GO:0006955,GO:0007186,GO:0007204,GO:0009897,GO:0016493,GO:0019722,GO:0019957,GO:0042379,GO:0048020,GO:0060326,GO:0070098" chemokine receptor activity|cytoplasm|plasma membrane|integral component of plasma membrane|chemotaxis|inflammatory response|immune response|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|external side of plasma membrane|C-C chemokine receptor activity|calcium-mediated signaling|C-C chemokine binding|chemokine receptor binding|CCR chemokine receptor binding|cell chemotaxis|chemokine-mediated signaling pathway CCS 321.9854021 302.7604398 341.2103644 1.126997849 0.172484762 0.580684071 1 15.15738107 16.79648611 9973 copper chaperone for superoxide dismutase "GO:0004784,GO:0005507,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006801,GO:0015035,GO:0015680,GO:0019430,GO:0030001,GO:0034599,GO:0045296,GO:0051353,GO:0055114" superoxide dismutase activity|copper ion binding|protein binding|nucleus|cytoplasm|cytosol|superoxide metabolic process|protein disulfide oxidoreductase activity|protein maturation by copper ion transfer|removal of superoxide radicals|metal ion transport|cellular response to oxidative stress|cadherin binding|positive regulation of oxidoreductase activity|oxidation-reduction process "hsa05014,hsa05022" Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases CCSAP 687.6134671 729.3301317 645.8968024 0.885602794 -0.175268321 0.497156721 1 5.663176004 4.931399829 126731 "centriole, cilia and spindle associated protein" "GO:0005813,GO:0005814,GO:0005819,GO:0005929,GO:0005930,GO:0007049,GO:0007275,GO:0008017,GO:0030424,GO:0035869,GO:0036064,GO:0045995,GO:0051301,GO:0060296,GO:0061673,GO:0072686,GO:1901673,GO:1990755" centrosome|centriole|spindle|cilium|axoneme|cell cycle|multicellular organism development|microtubule binding|axon|ciliary transition zone|ciliary basal body|regulation of embryonic development|cell division|regulation of cilium beat frequency involved in ciliary motility|mitotic spindle astral microtubule|mitotic spindle|regulation of mitotic spindle assembly|mitotic spindle microtubule depolymerization CCSER1 30.74189934 37.45489978 24.0288989 0.641542203 -0.640383922 0.38284597 1 0.054955576 0.034666354 401145 coiled-coil serine rich protein 1 CCSER2 1449.052889 1416.003294 1482.102484 1.04668011 0.065820588 0.785405131 1 7.59339764 7.814861634 54462 coiled-coil serine rich protein 2 "GO:0001578,GO:0005737,GO:0008017,GO:0015630" microtubule bundle formation|cytoplasm|microtubule binding|microtubule cytoskeleton CCT2 4745.101157 4387.425343 5102.77697 1.16304588 0.21790801 0.363055737 1 114.9478777 131.4525402 10576 chaperonin containing TCP1 subunit 2 "GO:0002199,GO:0005515,GO:0005524,GO:0005576,GO:0005829,GO:0005832,GO:0005874,GO:0006457,GO:0007339,GO:0031625,GO:0032212,GO:0035578,GO:0043312,GO:0044183,GO:0044297,GO:0050821,GO:0051082,GO:0051086,GO:0051131,GO:0051973,GO:0070062,GO:0090666,GO:1901998,GO:1904851,GO:1904871,GO:1904874" zona pellucida receptor complex|protein binding|ATP binding|extracellular region|cytosol|chaperonin-containing T-complex|microtubule|protein folding|binding of sperm to zona pellucida|ubiquitin protein ligase binding|positive regulation of telomere maintenance via telomerase|azurophil granule lumen|neutrophil degranulation|protein folding chaperone|cell body|protein stabilization|unfolded protein binding|chaperone mediated protein folding independent of cofactor|chaperone-mediated protein complex assembly|positive regulation of telomerase activity|extracellular exosome|scaRNA localization to Cajal body|toxin transport|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCT3 6690.685562 6562.930772 6818.440352 1.038932238 0.05510156 0.82159073 1 177.1631528 180.9805074 7203 chaperonin containing TCP1 subunit 3 "GO:0002199,GO:0003723,GO:0005515,GO:0005524,GO:0005829,GO:0005832,GO:0005856,GO:0005874,GO:0006457,GO:0007339,GO:0032212,GO:0044183,GO:0044297,GO:0046931,GO:0050821,GO:0051082,GO:0070062,GO:1901998,GO:1904851,GO:1904871,GO:1904874" zona pellucida receptor complex|RNA binding|protein binding|ATP binding|cytosol|chaperonin-containing T-complex|cytoskeleton|microtubule|protein folding|binding of sperm to zona pellucida|positive regulation of telomere maintenance via telomerase|protein folding chaperone|cell body|pore complex assembly|protein stabilization|unfolded protein binding|extracellular exosome|toxin transport|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCT4 6650.810722 6033.360105 7268.261339 1.204678854 0.268648601 0.270244309 1 134.6672271 159.5160488 10575 chaperonin containing TCP1 subunit 4 "GO:0002199,GO:0003723,GO:0005515,GO:0005524,GO:0005654,GO:0005813,GO:0005829,GO:0005832,GO:0005874,GO:0006457,GO:0007339,GO:0032212,GO:0042470,GO:0042995,GO:0044183,GO:0044297,GO:0050821,GO:0051082,GO:0051973,GO:0070062,GO:0090666,GO:1901998,GO:1904851,GO:1904871,GO:1904874" zona pellucida receptor complex|RNA binding|protein binding|ATP binding|nucleoplasm|centrosome|cytosol|chaperonin-containing T-complex|microtubule|protein folding|binding of sperm to zona pellucida|positive regulation of telomere maintenance via telomerase|melanosome|cell projection|protein folding chaperone|cell body|protein stabilization|unfolded protein binding|positive regulation of telomerase activity|extracellular exosome|scaRNA localization to Cajal body|toxin transport|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCT5 8459.812216 8155.804426 8763.820007 1.074550044 0.103732674 0.675636268 1 115.3007397 121.8231763 22948 chaperonin containing TCP1 subunit 5 "GO:0003730,GO:0005515,GO:0005524,GO:0005813,GO:0005829,GO:0005832,GO:0005874,GO:0006457,GO:0007339,GO:0009615,GO:0031681,GO:0032212,GO:0044183,GO:0044297,GO:0048027,GO:0048487,GO:0050821,GO:0051082,GO:0070062,GO:1901998,GO:1904851,GO:1904871,GO:1904874" mRNA 3'-UTR binding|protein binding|ATP binding|centrosome|cytosol|chaperonin-containing T-complex|microtubule|protein folding|binding of sperm to zona pellucida|response to virus|G-protein beta-subunit binding|positive regulation of telomere maintenance via telomerase|protein folding chaperone|cell body|mRNA 5'-UTR binding|beta-tubulin binding|protein stabilization|unfolded protein binding|extracellular exosome|toxin transport|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCT6A 7339.355163 6837.600037 7841.110289 1.14676352 0.197567917 0.420426695 1 141.2190971 159.2349802 908 chaperonin containing TCP1 subunit 6A "GO:0003723,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005832,GO:0005874,GO:0006457,GO:0032212,GO:0044183,GO:0050821,GO:0051082,GO:0070062,GO:0071987,GO:1904851,GO:1904871,GO:1904874" RNA binding|protein binding|ATP binding|cytoplasm|cytosol|chaperonin-containing T-complex|microtubule|protein folding|positive regulation of telomere maintenance via telomerase|protein folding chaperone|protein stabilization|unfolded protein binding|extracellular exosome|WD40-repeat domain binding|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCT6B 3.923881751 2.080827765 5.766935736 2.771462315 1.470647391 0.503574097 1 0.051151522 0.139392277 10693 chaperonin containing TCP1 subunit 6B "GO:0005524,GO:0005829,GO:0005832,GO:0006457,GO:0044183,GO:0051082,GO:1901998" ATP binding|cytosol|chaperonin-containing T-complex|protein folding|protein folding chaperone|unfolded protein binding|toxin transport CCT7 6585.699952 6014.632656 7156.767248 1.18989266 0.250831434 0.302991375 1 157.9674657 184.8189995 10574 chaperonin containing TCP1 subunit 7 "GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005832,GO:0005874,GO:0006457,GO:0007339,GO:0032212,GO:0042802,GO:0044183,GO:0044297,GO:0050821,GO:0051082,GO:0070062,GO:1901998,GO:1904851,GO:1904871,GO:1904874" protein binding|ATP binding|cytoplasm|cytosol|chaperonin-containing T-complex|microtubule|protein folding|binding of sperm to zona pellucida|positive regulation of telomere maintenance via telomerase|identical protein binding|protein folding chaperone|cell body|protein stabilization|unfolded protein binding|extracellular exosome|toxin transport|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCT8 7620.430342 6596.224016 8644.636668 1.310543221 0.390164934 0.112774573 1 162.8253249 209.8188393 10694 chaperonin containing TCP1 subunit 8 "GO:0002199,GO:0005515,GO:0005524,GO:0005576,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005832,GO:0005874,GO:0005929,GO:0006457,GO:0007339,GO:0016887,GO:0032212,GO:0034774,GO:0035578,GO:0043312,GO:0044183,GO:0044297,GO:0045111,GO:0045296,GO:0046931,GO:0050821,GO:0051082,GO:0070062,GO:1901998,GO:1904813,GO:1904851,GO:1904871,GO:1904874" zona pellucida receptor complex|protein binding|ATP binding|extracellular region|nucleoplasm|cytoplasm|centrosome|cytosol|chaperonin-containing T-complex|microtubule|cilium|protein folding|binding of sperm to zona pellucida|ATPase activity|positive regulation of telomere maintenance via telomerase|secretory granule lumen|azurophil granule lumen|neutrophil degranulation|protein folding chaperone|cell body|intermediate filament cytoskeleton|cadherin binding|pore complex assembly|protein stabilization|unfolded protein binding|extracellular exosome|toxin transport|ficolin-1-rich granule lumen|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCZ1 183.7927949 169.5874629 197.9981269 1.167528092 0.223457263 0.558893144 1 3.804359481 4.367370789 51622 "CCZ1 homolog, vacuolar protein trafficking and biogenesis associated" "GO:0005085,GO:0005515,GO:0005765,GO:0005829,GO:0016192,GO:0035658,GO:0043231,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|lysosomal membrane|cytosol|vesicle-mediated transport|Mon1-Ccz1 complex|intracellular membrane-bounded organelle|regulation of catalytic activity CCZ1B 759.4378523 684.5923348 834.2833698 1.218657188 0.285292349 0.260483749 1 20.14081294 24.13402338 221960 "CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated" "GO:0005765,GO:0016192,GO:0035658,GO:0043231" lysosomal membrane|vesicle-mediated transport|Mon1-Ccz1 complex|intracellular membrane-bounded organelle CD109 2586.834673 2873.623144 2300.046203 0.800399387 -0.321208033 0.174288528 1 16.98150655 13.36454393 135228 CD109 molecule "GO:0001933,GO:0001942,GO:0002576,GO:0004867,GO:0005576,GO:0005615,GO:0005829,GO:0005886,GO:0009986,GO:0010839,GO:0010951,GO:0030512,GO:0031092,GO:0031225,GO:0045616,GO:0050431,GO:0061045,GO:0072675" negative regulation of protein phosphorylation|hair follicle development|platelet degranulation|serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|cytosol|plasma membrane|cell surface|negative regulation of keratinocyte proliferation|negative regulation of endopeptidase activity|negative regulation of transforming growth factor beta receptor signaling pathway|platelet alpha granule membrane|anchored component of membrane|regulation of keratinocyte differentiation|transforming growth factor beta binding|negative regulation of wound healing|osteoclast fusion CD14 21.45743232 20.80827765 22.10658699 1.062393888 0.087318751 0.979502542 1 0.727242655 0.759689433 929 CD14 molecule "GO:0001530,GO:0001847,GO:0002224,GO:0002755,GO:0002756,GO:0005515,GO:0005576,GO:0005615,GO:0005794,GO:0005886,GO:0006898,GO:0006909,GO:0006915,GO:0006954,GO:0007166,GO:0007249,GO:0009408,GO:0009897,GO:0010008,GO:0016019,GO:0030667,GO:0031362,GO:0031663,GO:0032026,GO:0032481,GO:0032729,GO:0032757,GO:0032760,GO:0034128,GO:0034142,GO:0034612,GO:0035666,GO:0038123,GO:0038124,GO:0043312,GO:0045087,GO:0045121,GO:0045471,GO:0045807,GO:0046696,GO:0051602,GO:0070062,GO:0070266,GO:0070891,GO:0071219,GO:0071222,GO:0071223,GO:0071723,GO:0071726,GO:0071727,GO:0097190,GO:1901224" lipopolysaccharide binding|opsonin receptor activity|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|protein binding|extracellular region|extracellular space|Golgi apparatus|plasma membrane|receptor-mediated endocytosis|phagocytosis|apoptotic process|inflammatory response|cell surface receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|response to heat|external side of plasma membrane|endosome membrane|peptidoglycan immune receptor activity|secretory granule membrane|anchored component of external side of plasma membrane|lipopolysaccharide-mediated signaling pathway|response to magnesium ion|positive regulation of type I interferon production|positive regulation of interferon-gamma production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|negative regulation of MyD88-independent toll-like receptor signaling pathway|toll-like receptor 4 signaling pathway|response to tumor necrosis factor|TRIF-dependent toll-like receptor signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|neutrophil degranulation|innate immune response|membrane raft|response to ethanol|positive regulation of endocytosis|lipopolysaccharide receptor complex|response to electrical stimulus|extracellular exosome|necroptotic process|lipoteichoic acid binding|cellular response to molecule of bacterial origin|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|lipopeptide binding|cellular response to diacyl bacterial lipopeptide|cellular response to triacyl bacterial lipopeptide|apoptotic signaling pathway|positive regulation of NIK/NF-kappaB signaling "hsa04010,hsa04064,hsa04145,hsa04620,hsa04640,hsa05131,hsa05132,hsa05133,hsa05134,hsa05146,hsa05152,hsa05202,hsa05221" MAPK signaling pathway|NF-kappa B signaling pathway|Phagosome|Toll-like receptor signaling pathway|Hematopoietic cell lineage|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Amoebiasis|Tuberculosis|Transcriptional misregulation in cancer|Acute myeloid leukemia CD151 6414.037306 5557.890961 7270.183651 1.308083174 0.387454277 0.111234588 1 183.0953245 235.4961396 977 CD151 molecule (Raph blood group) "GO:0005178,GO:0005515,GO:0005604,GO:0005829,GO:0005886,GO:0005887,GO:0005925,GO:0007155,GO:0009986,GO:0016020,GO:0016032,GO:0016477,GO:0030335,GO:0031581,GO:0042098,GO:0044319,GO:0045807" "integrin binding|protein binding|basement membrane|cytosol|plasma membrane|integral component of plasma membrane|focal adhesion|cell adhesion|cell surface|membrane|viral process|cell migration|positive regulation of cell migration|hemidesmosome assembly|T cell proliferation|wound healing, spreading of cells|positive regulation of endocytosis" CD163L1 1063.572058 1061.22216 1065.921955 1.004428663 0.006375103 0.983554078 1 8.902149678 8.791949159 283316 CD163 molecule like 1 "GO:0005044,GO:0005576,GO:0006897,GO:0009897,GO:0016021" scavenger receptor activity|extracellular region|endocytosis|external side of plasma membrane|integral component of membrane CD164 3439.746843 3652.893142 3226.600544 0.883300009 -0.179024569 0.450730516 1 59.87352373 52.00130369 8763 CD164 molecule "GO:0005515,GO:0005576,GO:0005764,GO:0005765,GO:0005768,GO:0005886,GO:0005887,GO:0006955,GO:0007155,GO:0007157,GO:0007162,GO:0007165,GO:0007275,GO:0007517,GO:0008285,GO:0010008,GO:0030097,GO:0031410" protein binding|extracellular region|lysosome|lysosomal membrane|endosome|plasma membrane|integral component of plasma membrane|immune response|cell adhesion|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|negative regulation of cell adhesion|signal transduction|multicellular organism development|muscle organ development|negative regulation of cell population proliferation|endosome membrane|hemopoiesis|cytoplasmic vesicle hsa04142 Lysosome CD177 54.43867528 66.58648849 42.29086206 0.635126781 -0.654883491 0.262298229 1 1.259248232 0.786399002 57126 CD177 molecule "GO:0002020,GO:0005178,GO:0005515,GO:0005886,GO:0007155,GO:0007159,GO:0007596,GO:0030027,GO:0030100,GO:0030667,GO:0032930,GO:0034394,GO:0035579,GO:0043312,GO:0043315,GO:0044853,GO:0045087,GO:0045217,GO:0046658,GO:0048306,GO:0050900,GO:0070062,GO:0070821,GO:0072672,GO:0098742,GO:1990266,GO:2001044" protease binding|integrin binding|protein binding|plasma membrane|cell adhesion|leukocyte cell-cell adhesion|blood coagulation|lamellipodium|regulation of endocytosis|secretory granule membrane|positive regulation of superoxide anion generation|protein localization to cell surface|specific granule membrane|neutrophil degranulation|positive regulation of neutrophil degranulation|plasma membrane raft|innate immune response|cell-cell junction maintenance|anchored component of plasma membrane|calcium-dependent protein binding|leukocyte migration|extracellular exosome|tertiary granule membrane|neutrophil extravasation|cell-cell adhesion via plasma-membrane adhesion molecules|neutrophil migration|regulation of integrin-mediated signaling pathway CD207 6.366400604 3.121241648 9.61155956 3.079402572 1.622650484 0.289347527 1 0.054704411 0.165638004 50489 CD207 molecule "GO:0002479,GO:0005515,GO:0005537,GO:0005886,GO:0006898,GO:0016021,GO:0030139,GO:0030246,GO:0030669,GO:0031901,GO:0051607" "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|mannose binding|plasma membrane|receptor-mediated endocytosis|integral component of membrane|endocytic vesicle|carbohydrate binding|clathrin-coated endocytic vesicle membrane|early endosome membrane|defense response to virus" CD22 80.4144238 105.0818021 55.74704545 0.530510938 -0.914545598 0.070253404 1 1.71289635 0.893504214 933 CD22 molecule "GO:0001791,GO:0002638,GO:0005102,GO:0005515,GO:0005737,GO:0005769,GO:0005886,GO:0005887,GO:0007155,GO:0009897,GO:0009986,GO:0016021,GO:0019903,GO:0030100,GO:0030246,GO:0030888,GO:0032809,GO:0033691,GO:0042113,GO:0042609,GO:0050776,GO:0050849,GO:0050859,GO:0055037,GO:0070062" IgM binding|negative regulation of immunoglobulin production|signaling receptor binding|protein binding|cytoplasm|early endosome|plasma membrane|integral component of plasma membrane|cell adhesion|external side of plasma membrane|cell surface|integral component of membrane|protein phosphatase binding|regulation of endocytosis|carbohydrate binding|regulation of B cell proliferation|neuronal cell body membrane|sialic acid binding|B cell activation|CD4 receptor binding|regulation of immune response|negative regulation of calcium-mediated signaling|negative regulation of B cell receptor signaling pathway|recycling endosome|extracellular exosome "hsa04514,hsa04640,hsa04662" Cell adhesion molecules|Hematopoietic cell lineage|B cell receptor signaling pathway CD226 4.562975582 6.242483296 2.883467868 0.461910386 -1.11431511 0.584550016 1 0.023540832 0.010691797 10666 CD226 molecule "GO:0001816,GO:0002729,GO:0002860,GO:0002891,GO:0005178,GO:0005515,GO:0005886,GO:0005887,GO:0007155,GO:0007165,GO:0008037,GO:0009897,GO:0009986,GO:0019901,GO:0032729,GO:0033005,GO:0045121,GO:0045954,GO:0050776,GO:0050839,GO:0050862,GO:0060369" cytokine production|positive regulation of natural killer cell cytokine production|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of immunoglobulin mediated immune response|integrin binding|protein binding|plasma membrane|integral component of plasma membrane|cell adhesion|signal transduction|cell recognition|external side of plasma membrane|cell surface|protein kinase binding|positive regulation of interferon-gamma production|positive regulation of mast cell activation|membrane raft|positive regulation of natural killer cell mediated cytotoxicity|regulation of immune response|cell adhesion molecule binding|positive regulation of T cell receptor signaling pathway|positive regulation of Fc receptor mediated stimulatory signaling pathway hsa04514 Cell adhesion molecules CD24 57.05983166 21.84869154 92.27097178 4.223180671 2.078329968 0.000521067 0.127242579 0.372056321 1.544968139 100133941 CD24 molecule "GO:0001666,GO:0001775,GO:0001959,GO:0002237,GO:0002768,GO:0005515,GO:0007204,GO:0009986,GO:0016020,GO:0016055,GO:0016477,GO:0019901,GO:0030296,GO:0030856,GO:0031295,GO:0031362,GO:0032597,GO:0032600,GO:0032913,GO:0042104,GO:0042325,GO:0042632,GO:0043406,GO:0043408,GO:0043627,GO:0045121,GO:0045730,GO:0061098,GO:0072112,GO:0072139,GO:0097193,GO:0098609,GO:2000768" response to hypoxia|cell activation|regulation of cytokine-mediated signaling pathway|response to molecule of bacterial origin|immune response-regulating cell surface receptor signaling pathway|protein binding|positive regulation of cytosolic calcium ion concentration|cell surface|membrane|Wnt signaling pathway|cell migration|protein kinase binding|protein tyrosine kinase activator activity|regulation of epithelial cell differentiation|T cell costimulation|anchored component of external side of plasma membrane|B cell receptor transport into membrane raft|chemokine receptor transport out of membrane raft|negative regulation of transforming growth factor beta3 production|positive regulation of activated T cell proliferation|regulation of phosphorylation|cholesterol homeostasis|positive regulation of MAP kinase activity|regulation of MAPK cascade|response to estrogen|membrane raft|respiratory burst|positive regulation of protein tyrosine kinase activity|glomerular visceral epithelial cell differentiation|glomerular parietal epithelial cell differentiation|intrinsic apoptotic signaling pathway|cell-cell adhesion|positive regulation of nephron tubule epithelial cell differentiation hsa04640 Hematopoietic cell lineage CD27 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.071847254 939 CD27 molecule "GO:0004888,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0007166,GO:0009897,GO:0016064,GO:0033209,GO:0043027,GO:0043066,GO:0043154,GO:0045471,GO:0045579,GO:0045582,GO:0046330,GO:0070233,GO:0097191,GO:1901224" transmembrane signaling receptor activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|external side of plasma membrane|immunoglobulin mediated immune response|tumor necrosis factor-mediated signaling pathway|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|response to ethanol|positive regulation of B cell differentiation|positive regulation of T cell differentiation|positive regulation of JNK cascade|negative regulation of T cell apoptotic process|extrinsic apoptotic signaling pathway|positive regulation of NIK/NF-kappaB signaling hsa04060 Cytokine-cytokine receptor interaction CD274 1385.11774 1163.182721 1607.052758 1.38159958 0.466339549 0.05181214 1 16.54943321 22.48208035 29126 CD274 molecule "GO:0002250,GO:0002845,GO:0005515,GO:0005654,GO:0005886,GO:0006955,GO:0007165,GO:0007166,GO:0009897,GO:0015629,GO:0016021,GO:0030335,GO:0031295,GO:0031901,GO:0032689,GO:0032693,GO:0032733,GO:0034097,GO:0042102,GO:0042130,GO:0046006,GO:0046007,GO:0055038,GO:0070062,GO:0070232,GO:0071222,GO:1901998,GO:1903556,GO:1905399,GO:1905404,GO:2000562,GO:2001186" "adaptive immune response|positive regulation of tolerance induction to tumor cell|protein binding|nucleoplasm|plasma membrane|immune response|signal transduction|cell surface receptor signaling pathway|external side of plasma membrane|actin cytoskeleton|integral component of membrane|positive regulation of cell migration|T cell costimulation|early endosome membrane|negative regulation of interferon-gamma production|negative regulation of interleukin-10 production|positive regulation of interleukin-10 production|response to cytokine|positive regulation of T cell proliferation|negative regulation of T cell proliferation|regulation of activated T cell proliferation|negative regulation of activated T cell proliferation|recycling endosome membrane|extracellular exosome|regulation of T cell apoptotic process|cellular response to lipopolysaccharide|toxin transport|negative regulation of tumor necrosis factor superfamily cytokine production|regulation of activated CD4-positive, alpha-beta T cell apoptotic process|positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process|negative regulation of CD4-positive, alpha-beta T cell proliferation|negative regulation of CD8-positive, alpha-beta T cell activation" "hsa04514,hsa05235" Cell adhesion molecules|PD-L1 expression and PD-1 checkpoint pathway in cancer CD276 1993.300633 2128.686804 1857.914463 0.872798412 -0.196279617 0.407180328 1 29.96679039 25.71729912 80381 CD276 molecule "GO:0001817,GO:0005102,GO:0005515,GO:0009897,GO:0016021,GO:0032729,GO:0042102,GO:0042110,GO:0050776,GO:0050852" regulation of cytokine production|signaling receptor binding|protein binding|external side of plasma membrane|integral component of membrane|positive regulation of interferon-gamma production|positive regulation of T cell proliferation|T cell activation|regulation of immune response|T cell receptor signaling pathway hsa04514 Cell adhesion molecules CD28 2.40288989 0 4.80577978 Inf Inf 0.18976424 1 0 0.054906131 940 CD28 molecule "GO:0001772,GO:0001816,GO:0002020,GO:0002863,GO:0005515,GO:0005829,GO:0005886,GO:0005887,GO:0006959,GO:0007166,GO:0009897,GO:0009986,GO:0010628,GO:0010629,GO:0014068,GO:0015026,GO:0019901,GO:0031295,GO:0032733,GO:0032743,GO:0032753,GO:0042102,GO:0042110,GO:0042802,GO:0043066,GO:0045060,GO:0045066,GO:0045070,GO:0045589,GO:0045727,GO:0045840,GO:0045944,GO:0046641,GO:0048304,GO:0050690,GO:0050852,GO:0051897,GO:0097190,GO:0098636" immunological synapse|cytokine production|protease binding|positive regulation of inflammatory response to antigenic stimulus|protein binding|cytosol|plasma membrane|integral component of plasma membrane|humoral immune response|cell surface receptor signaling pathway|external side of plasma membrane|cell surface|positive regulation of gene expression|negative regulation of gene expression|positive regulation of phosphatidylinositol 3-kinase signaling|coreceptor activity|protein kinase binding|T cell costimulation|positive regulation of interleukin-10 production|positive regulation of interleukin-2 production|positive regulation of interleukin-4 production|positive regulation of T cell proliferation|T cell activation|identical protein binding|negative regulation of apoptotic process|negative thymic T cell selection|regulatory T cell differentiation|positive regulation of viral genome replication|regulation of regulatory T cell differentiation|positive regulation of translation|positive regulation of mitotic nuclear division|positive regulation of transcription by RNA polymerase II|positive regulation of alpha-beta T cell proliferation|positive regulation of isotype switching to IgG isotypes|regulation of defense response to virus by virus|T cell receptor signaling pathway|positive regulation of protein kinase B signaling|apoptotic signaling pathway|protein complex involved in cell adhesion "hsa04514,hsa04660,hsa04672,hsa04940,hsa05162,hsa05235,hsa05320,hsa05322,hsa05323,hsa05330,hsa05332,hsa05416" Cell adhesion molecules|T cell receptor signaling pathway|Intestinal immune network for IgA production|Type I diabetes mellitus|Measles|PD-L1 expression and PD-1 checkpoint pathway in cancer|Autoimmune thyroid disease|Systemic lupus erythematosus|Rheumatoid arthritis|Allograft rejection|Graft-versus-host disease|Viral myocarditis CD2AP 1338.961518 1314.042734 1363.880302 1.0379269 0.05370484 0.825811461 1 12.23661588 12.48818356 23607 CD2 associated protein "GO:0001650,GO:0001726,GO:0005172,GO:0005200,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0006930,GO:0007015,GO:0007049,GO:0007165,GO:0008013,GO:0008022,GO:0015629,GO:0016050,GO:0017124,GO:0030139,GO:0030424,GO:0030425,GO:0031941,GO:0032911,GO:0034451,GO:0042802,GO:0043161,GO:0044877,GO:0045296,GO:0048259,GO:0048471,GO:0050714,GO:0051058,GO:0051301,GO:0065003,GO:0070062,GO:0098609,GO:1900182,GO:2000249" "fibrillar center|ruffle|vascular endothelial growth factor receptor binding|structural constituent of cytoskeleton|protein binding|cytoplasm|cytosol|plasma membrane|cell-cell junction|substrate-dependent cell migration, cell extension|actin filament organization|cell cycle|signal transduction|beta-catenin binding|protein C-terminus binding|actin cytoskeleton|vesicle organization|SH3 domain binding|endocytic vesicle|axon|dendrite|filamentous actin|negative regulation of transforming growth factor beta1 production|centriolar satellite|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein-containing complex binding|cadherin binding|regulation of receptor-mediated endocytosis|perinuclear region of cytoplasm|positive regulation of protein secretion|negative regulation of small GTPase mediated signal transduction|cell division|protein-containing complex assembly|extracellular exosome|cell-cell adhesion|positive regulation of protein localization to nucleus|regulation of actin cytoskeleton reorganization" hsa05100 Bacterial invasion of epithelial cells CD2BP2 2137.534392 1978.867205 2296.201579 1.160361632 0.214574498 0.364435588 1 29.43380873 33.58234369 10421 CD2 cytoplasmic tail binding protein 2 "GO:0000244,GO:0000398,GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005682,GO:0005737,GO:0005829,GO:0010923,GO:0016607,GO:0043021,GO:0046540" "spliceosomal tri-snRNP complex assembly|mRNA splicing, via spliceosome|fibrillar center|protein binding|nucleus|nucleoplasm|U5 snRNP|cytoplasm|cytosol|negative regulation of phosphatase activity|nuclear speck|ribonucleoprotein complex binding|U4/U6 x U5 tri-snRNP complex" CD302 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.042363919 0.064136282 9936 CD302 molecule "GO:0005515,GO:0005902,GO:0005938,GO:0006909,GO:0009897,GO:0016020,GO:0016021,GO:0030175,GO:0030246,GO:0038023" protein binding|microvillus|cell cortex|phagocytosis|external side of plasma membrane|membrane|integral component of membrane|filopodium|carbohydrate binding|signaling receptor activity CD320 404.6492304 391.1956199 418.1028409 1.06878201 0.095967629 0.745971628 1 16.66192438 17.50997285 51293 CD320 molecule "GO:0005509,GO:0005515,GO:0005783,GO:0005886,GO:0005887,GO:0007165,GO:0008083,GO:0009235,GO:0010008,GO:0015420,GO:0015889,GO:0016020,GO:0030890,GO:0031296,GO:0031419" calcium ion binding|protein binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|signal transduction|growth factor activity|cobalamin metabolic process|endosome membrane|ATPase-coupled vitamin B12 transmembrane transporter activity|cobalamin transport|membrane|positive regulation of B cell proliferation|B cell costimulation|cobalamin binding CD33 3.522561699 4.161655531 2.883467868 0.692865579 -0.529352609 0.940314863 1 0.078508274 0.053485443 945 CD33 molecule "GO:0002765,GO:0005515,GO:0005654,GO:0005777,GO:0005794,GO:0005886,GO:0005887,GO:0007155,GO:0007165,GO:0007267,GO:0008285,GO:0009897,GO:0019903,GO:0030246,GO:0032691,GO:0032717,GO:0032720,GO:0033691,GO:0035579,GO:0038023,GO:0043312,GO:0050714,GO:0050776,GO:0051926,GO:0070821,GO:0098609,GO:0150102,GO:1903615" immune response-inhibiting signal transduction|protein binding|nucleoplasm|peroxisome|Golgi apparatus|plasma membrane|integral component of plasma membrane|cell adhesion|signal transduction|cell-cell signaling|negative regulation of cell population proliferation|external side of plasma membrane|protein phosphatase binding|carbohydrate binding|negative regulation of interleukin-1 beta production|negative regulation of interleukin-8 production|negative regulation of tumor necrosis factor production|sialic acid binding|specific granule membrane|signaling receptor activity|neutrophil degranulation|positive regulation of protein secretion|regulation of immune response|negative regulation of calcium ion transport|tertiary granule membrane|cell-cell adhesion|negative regulation of monocyte activation|positive regulation of protein tyrosine phosphatase activity hsa04640 Hematopoietic cell lineage CD34 9.329126399 5.202069413 13.45618338 2.586698161 1.371111717 0.266650381 1 0.034005988 0.08649128 947 CD34 molecule "GO:0001894,GO:0001935,GO:0003094,GO:0003158,GO:0005515,GO:0005737,GO:0005764,GO:0005886,GO:0005887,GO:0007160,GO:0007165,GO:0008134,GO:0008217,GO:0009897,GO:0009925,GO:0010628,GO:0010629,GO:0016324,GO:0030097,GO:0030195,GO:0030246,GO:0032703,GO:0032720,GO:0032733,GO:0035759,GO:0036053,GO:0038001,GO:0042482,GO:0043199,GO:0045019,GO:0045171,GO:0045766,GO:0048471,GO:0048870,GO:0050776,GO:0050900,GO:0060290,GO:0061042,GO:0071425,GO:0071636,GO:0071657,GO:0071971,GO:0072011,GO:0072089,GO:0072254,GO:0098609,GO:1900035,GO:1900038,GO:1900168,GO:1901215,GO:2001214" tissue homeostasis|endothelial cell proliferation|glomerular filtration|endothelium development|protein binding|cytoplasm|lysosome|plasma membrane|integral component of plasma membrane|cell-matrix adhesion|signal transduction|transcription factor binding|regulation of blood pressure|external side of plasma membrane|basal plasma membrane|positive regulation of gene expression|negative regulation of gene expression|apical plasma membrane|hemopoiesis|negative regulation of blood coagulation|carbohydrate binding|negative regulation of interleukin-2 production|negative regulation of tumor necrosis factor production|positive regulation of interleukin-10 production|mesangial cell-matrix adhesion|glomerular endothelium fenestra|paracrine signaling|positive regulation of odontogenesis|sulfate binding|negative regulation of nitric oxide biosynthetic process|intercellular bridge|positive regulation of angiogenesis|perinuclear region of cytoplasm|cell motility|regulation of immune response|leukocyte migration|transdifferentiation|vascular wound healing|hematopoietic stem cell proliferation|positive regulation of transforming growth factor beta production|positive regulation of granulocyte colony-stimulating factor production|extracellular exosome assembly|glomerular endothelium development|stem cell proliferation|metanephric glomerular mesangial cell differentiation|cell-cell adhesion|negative regulation of cellular response to heat|negative regulation of cellular response to hypoxia|positive regulation of glial cell-derived neurotrophic factor production|negative regulation of neuron death|positive regulation of vasculogenesis "hsa04514,hsa04640" Cell adhesion molecules|Hematopoietic cell lineage CD36 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.028319437 0.042873829 948 CD36 molecule "GO:0000122,GO:0001540,GO:0001954,GO:0002224,GO:0002479,GO:0002532,GO:0002576,GO:0002755,GO:0005041,GO:0005044,GO:0005324,GO:0005515,GO:0005615,GO:0005737,GO:0005794,GO:0005886,GO:0005887,GO:0005901,GO:0006629,GO:0006631,GO:0006898,GO:0006910,GO:0006911,GO:0007155,GO:0007204,GO:0007263,GO:0007596,GO:0008035,GO:0008289,GO:0009897,GO:0009986,GO:0010628,GO:0010744,GO:0010886,GO:0010942,GO:0015636,GO:0015909,GO:0015911,GO:0015912,GO:0016020,GO:0016324,GO:0019216,GO:0019221,GO:0019915,GO:0019934,GO:0030169,GO:0030194,GO:0030299,GO:0030301,GO:0030666,GO:0031092,GO:0031526,GO:0031623,GO:0031664,GO:0032611,GO:0032735,GO:0032755,GO:0032760,GO:0033993,GO:0034121,GO:0034197,GO:0034381,GO:0034383,GO:0035325,GO:0035579,GO:0035634,GO:0038124,GO:0042308,GO:0042953,GO:0043123,GO:0043235,GO:0043254,GO:0043277,GO:0043312,GO:0044539,GO:0044877,GO:0045121,GO:0045335,GO:0045429,GO:0050431,GO:0050731,GO:0050830,GO:0050892,GO:0050909,GO:0051092,GO:0055096,GO:0060100,GO:0060907,GO:0070053,GO:0070374,GO:0070508,GO:0070542,GO:0070543,GO:0070892,GO:0071222,GO:0071223,GO:0071404,GO:0071447,GO:0071726,GO:0071813,GO:0071944,GO:0097009,GO:0098900,GO:0120162,GO:0140052,GO:0150024,GO:0150025,GO:0150094,GO:1900227,GO:1901480,GO:1903428,GO:1904646,GO:1990000,GO:1990379,GO:2000121,GO:2000334" "negative regulation of transcription by RNA polymerase II|amyloid-beta binding|positive regulation of cell-matrix adhesion|toll-like receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|production of molecular mediator involved in inflammatory response|platelet degranulation|MyD88-dependent toll-like receptor signaling pathway|low-density lipoprotein particle receptor activity|scavenger receptor activity|long-chain fatty acid transporter activity|protein binding|extracellular space|cytoplasm|Golgi apparatus|plasma membrane|integral component of plasma membrane|caveola|lipid metabolic process|fatty acid metabolic process|receptor-mediated endocytosis|phagocytosis, recognition|phagocytosis, engulfment|cell adhesion|positive regulation of cytosolic calcium ion concentration|nitric oxide mediated signal transduction|blood coagulation|high-density lipoprotein particle binding|lipid binding|external side of plasma membrane|cell surface|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of cholesterol storage|positive regulation of cell death|short-chain fatty acid transmembrane transporter activity|long-chain fatty acid transport|long-chain fatty acid import across plasma membrane|short-chain fatty acid transport|membrane|apical plasma membrane|regulation of lipid metabolic process|cytokine-mediated signaling pathway|lipid storage|cGMP-mediated signaling|low-density lipoprotein particle binding|positive regulation of blood coagulation|intestinal cholesterol absorption|cholesterol transport|endocytic vesicle membrane|platelet alpha granule membrane|brush border membrane|receptor internalization|regulation of lipopolysaccharide-mediated signaling pathway|interleukin-1 beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|response to lipid|regulation of toll-like receptor signaling pathway|triglyceride transport|plasma lipoprotein particle clearance|low-density lipoprotein particle clearance|Toll-like receptor binding|specific granule membrane|response to stilbenoid|toll-like receptor TLR6:TLR2 signaling pathway|negative regulation of protein import into nucleus|lipoprotein transport|positive regulation of I-kappaB kinase/NF-kappaB signaling|receptor complex|regulation of protein-containing complex assembly|apoptotic cell clearance|neutrophil degranulation|long-chain fatty acid import into cell|protein-containing complex binding|membrane raft|phagocytic vesicle|positive regulation of nitric oxide biosynthetic process|transforming growth factor beta binding|positive regulation of peptidyl-tyrosine phosphorylation|defense response to Gram-positive bacterium|intestinal absorption|sensory perception of taste|positive regulation of NF-kappaB transcription factor activity|low-density lipoprotein particle mediated signaling|positive regulation of phagocytosis, engulfment|positive regulation of macrophage cytokine production|thrombospondin receptor activity|positive regulation of ERK1 and ERK2 cascade|cholesterol import|response to fatty acid|response to linoleic acid|lipoteichoic acid immune receptor activity|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|cellular response to low-density lipoprotein particle stimulus|cellular response to hydroperoxide|cellular response to diacyl bacterial lipopeptide|lipoprotein particle binding|cell periphery|energy homeostasis|regulation of action potential|positive regulation of cold-induced thermogenesis|cellular response to oxidised low-density lipoprotein particle stimulus|oxidised low-density lipoprotein particle clearance|oxidised low-density lipoprotein particle receptor activity|amyloid-beta clearance by cellular catabolic process|positive regulation of NLRP3 inflammasome complex assembly|oleate transmembrane transporter activity|positive regulation of reactive oxygen species biosynthetic process|cellular response to amyloid-beta|amyloid fibril formation|lipid transport across blood-brain barrier|regulation of removal of superoxide radicals|positive regulation of blood microparticle formation" "hsa03320,hsa04145,hsa04152,hsa04512,hsa04640,hsa04920,hsa04931,hsa04975,hsa04979,hsa05144" PPAR signaling pathway|Phagosome|AMPK signaling pathway|ECM-receptor interaction|Hematopoietic cell lineage|Adipocytokine signaling pathway|Insulin resistance|Fat digestion and absorption|Cholesterol metabolism|Malaria CD38 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.029639667 0 952 CD38 molecule "GO:0001666,GO:0003953,GO:0005634,GO:0005886,GO:0007165,GO:0007204,GO:0007565,GO:0009986,GO:0010977,GO:0014824,GO:0016020,GO:0016021,GO:0016323,GO:0016740,GO:0016849,GO:0019674,GO:0030307,GO:0030667,GO:0030890,GO:0032024,GO:0032355,GO:0032526,GO:0032570,GO:0033194,GO:0042493,GO:0042802,GO:0043066,GO:0045779,GO:0045892,GO:0045893,GO:0045907,GO:0050135,GO:0050853,GO:0060292,GO:0061809,GO:0070062,GO:0070555,GO:0097190" "response to hypoxia|NAD+ nucleosidase activity|nucleus|plasma membrane|signal transduction|positive regulation of cytosolic calcium ion concentration|female pregnancy|cell surface|negative regulation of neuron projection development|artery smooth muscle contraction|membrane|integral component of membrane|basolateral plasma membrane|transferase activity|phosphorus-oxygen lyase activity|NAD metabolic process|positive regulation of cell growth|secretory granule membrane|positive regulation of B cell proliferation|positive regulation of insulin secretion|response to estradiol|response to retinoic acid|response to progesterone|response to hydroperoxide|response to drug|identical protein binding|negative regulation of apoptotic process|negative regulation of bone resorption|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of vasoconstriction|NAD(P)+ nucleosidase activity|B cell receptor signaling pathway|long-term synaptic depression|NAD+ nucleotidase, cyclic ADP-ribose generating|extracellular exosome|response to interleukin-1|apoptotic signaling pathway" "hsa00760,hsa04020,hsa04640,hsa04921,hsa04970,hsa04972" Nicotinate and nicotinamide metabolism|Calcium signaling pathway|Hematopoietic cell lineage|Oxytocin signaling pathway|Salivary secretion|Pancreatic secretion CD40 1205.831971 1238.09252 1173.571422 0.947886691 -0.077213483 0.752295327 1 37.6708793 35.11020471 958 CD40 molecule "GO:0001934,GO:0002768,GO:0003823,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0006874,GO:0006954,GO:0009897,GO:0009986,GO:0019899,GO:0019904,GO:0023035,GO:0030168,GO:0030890,GO:0031625,GO:0032735,GO:0033209,GO:0033590,GO:0034341,GO:0035631,GO:0035666,GO:0036018,GO:0038023,GO:0042100,GO:0042113,GO:0042531,GO:0042832,GO:0043025,GO:0043123,GO:0043196,GO:0043231,GO:0043406,GO:0043491,GO:0043536,GO:0043547,GO:0045766,GO:0045944,GO:0048304,GO:0050776,GO:0051092,GO:0051607,GO:0065003,GO:0070062,GO:0071222,GO:0071260,GO:0071347,GO:0071356,GO:0090037,GO:1901652,GO:2000353" positive regulation of protein phosphorylation|immune response-regulating cell surface receptor signaling pathway|antigen binding|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|inflammatory response|external side of plasma membrane|cell surface|enzyme binding|protein domain specific binding|CD40 signaling pathway|platelet activation|positive regulation of B cell proliferation|ubiquitin protein ligase binding|positive regulation of interleukin-12 production|tumor necrosis factor-mediated signaling pathway|response to cobalamin|response to interferon-gamma|CD40 receptor complex|TRIF-dependent toll-like receptor signaling pathway|cellular response to erythropoietin|signaling receptor activity|B cell proliferation|B cell activation|positive regulation of tyrosine phosphorylation of STAT protein|defense response to protozoan|neuronal cell body|positive regulation of I-kappaB kinase/NF-kappaB signaling|varicosity|intracellular membrane-bounded organelle|positive regulation of MAP kinase activity|protein kinase B signaling|positive regulation of blood vessel endothelial cell migration|positive regulation of GTPase activity|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|positive regulation of isotype switching to IgG isotypes|regulation of immune response|positive regulation of NF-kappaB transcription factor activity|defense response to virus|protein-containing complex assembly|extracellular exosome|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|cellular response to interleukin-1|cellular response to tumor necrosis factor|positive regulation of protein kinase C signaling|response to peptide|positive regulation of endothelial cell apoptotic process "hsa04060,hsa04064,hsa04514,hsa04620,hsa04672,hsa05144,hsa05145,hsa05166,hsa05169,hsa05202,hsa05310,hsa05320,hsa05322,hsa05330,hsa05340,hsa05416" Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Cell adhesion molecules|Toll-like receptor signaling pathway|Intestinal immune network for IgA production|Malaria|Toxoplasmosis|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Transcriptional misregulation in cancer|Asthma|Autoimmune thyroid disease|Systemic lupus erythematosus|Allograft rejection|Primary immunodeficiency|Viral myocarditis CD44 27358.94468 27331.6727 27386.21665 1.001995632 0.002876219 0.992168254 1 206.6942239 203.6410592 960 CD44 molecule (Indian blood group) "GO:0004888,GO:0004896,GO:0005515,GO:0005518,GO:0005540,GO:0005794,GO:0005829,GO:0005886,GO:0005887,GO:0005902,GO:0005925,GO:0006954,GO:0007155,GO:0007160,GO:0009986,GO:0016323,GO:0016324,GO:0016477,GO:0022617,GO:0030198,GO:0030214,GO:0030667,GO:0031258,GO:0033138,GO:0034116,GO:0035692,GO:0042110,GO:0042995,GO:0043066,GO:0043154,GO:0043312,GO:0043518,GO:0044319,GO:0044344,GO:0050731,GO:0050900,GO:0051216,GO:0060333,GO:0070062,GO:0070374,GO:0070487,GO:0098609,GO:1900625,GO:1902166,GO:2000392" "transmembrane signaling receptor activity|cytokine receptor activity|protein binding|collagen binding|hyaluronic acid binding|Golgi apparatus|cytosol|plasma membrane|integral component of plasma membrane|microvillus|focal adhesion|inflammatory response|cell adhesion|cell-matrix adhesion|cell surface|basolateral plasma membrane|apical plasma membrane|cell migration|extracellular matrix disassembly|extracellular matrix organization|hyaluronan catabolic process|secretory granule membrane|lamellipodium membrane|positive regulation of peptidyl-serine phosphorylation|positive regulation of heterotypic cell-cell adhesion|macrophage migration inhibitory factor receptor complex|T cell activation|cell projection|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|neutrophil degranulation|negative regulation of DNA damage response, signal transduction by p53 class mediator|wound healing, spreading of cells|cellular response to fibroblast growth factor stimulus|positive regulation of peptidyl-tyrosine phosphorylation|leukocyte migration|cartilage development|interferon-gamma-mediated signaling pathway|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|monocyte aggregation|cell-cell adhesion|positive regulation of monocyte aggregation|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of lamellipodium morphogenesis" "hsa04512,hsa04640,hsa05131,hsa05169,hsa05205,hsa05206" ECM-receptor interaction|Hematopoietic cell lineage|Shigellosis|Epstein-Barr virus infection|Proteoglycans in cancer|MicroRNAs in cancer CD46 4060.233992 3402.153396 4718.314588 1.386861214 0.471823421 0.047928428 1 53.59110799 73.07972713 4179 CD46 molecule "GO:0001618,GO:0002079,GO:0002250,GO:0002456,GO:0005515,GO:0005886,GO:0005887,GO:0005925,GO:0006958,GO:0007338,GO:0008593,GO:0009986,GO:0010628,GO:0010629,GO:0030449,GO:0032613,GO:0032733,GO:0035581,GO:0038023,GO:0042102,GO:0043382,GO:0045087,GO:0045296,GO:0045591,GO:0046718,GO:0070062,GO:0071636" "virus receptor activity|inner acrosomal membrane|adaptive immune response|T cell mediated immunity|protein binding|plasma membrane|integral component of plasma membrane|focal adhesion|complement activation, classical pathway|single fertilization|regulation of Notch signaling pathway|cell surface|positive regulation of gene expression|negative regulation of gene expression|regulation of complement activation|interleukin-10 production|positive regulation of interleukin-10 production|sequestering of extracellular ligand from receptor|signaling receptor activity|positive regulation of T cell proliferation|positive regulation of memory T cell differentiation|innate immune response|cadherin binding|positive regulation of regulatory T cell differentiation|viral entry into host cell|extracellular exosome|positive regulation of transforming growth factor beta production" "hsa04610,hsa05162" Complement and coagulation cascades|Measles CD47 2873.442816 2815.359966 2931.525666 1.041261402 0.058332293 0.80645503 1 14.81907358 15.17232032 961 CD47 molecule "GO:0005515,GO:0005886,GO:0005887,GO:0007229,GO:0008284,GO:0009986,GO:0016477,GO:0022409,GO:0030198,GO:0032649,GO:0032653,GO:0032655,GO:0032675,GO:0032680,GO:0034113,GO:0035579,GO:0035696,GO:0043312,GO:0045428,GO:0050729,GO:0050766,GO:0050870,GO:0050900,GO:0051496,GO:0070053,GO:0070062,GO:0070821,GO:0071346,GO:0071347,GO:0071349,GO:0086080,GO:0098632,GO:1904669,GO:1905450" protein binding|plasma membrane|integral component of plasma membrane|integrin-mediated signaling pathway|positive regulation of cell population proliferation|cell surface|cell migration|positive regulation of cell-cell adhesion|extracellular matrix organization|regulation of interferon-gamma production|regulation of interleukin-10 production|regulation of interleukin-12 production|regulation of interleukin-6 production|regulation of tumor necrosis factor production|heterotypic cell-cell adhesion|specific granule membrane|monocyte extravasation|neutrophil degranulation|regulation of nitric oxide biosynthetic process|positive regulation of inflammatory response|positive regulation of phagocytosis|positive regulation of T cell activation|leukocyte migration|positive regulation of stress fiber assembly|thrombospondin receptor activity|extracellular exosome|tertiary granule membrane|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to interleukin-12|protein binding involved in heterotypic cell-cell adhesion|cell-cell adhesion mediator activity|ATP export|negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis hsa04512 ECM-receptor interaction CD55 1378.125493 1421.205364 1335.045623 0.939375587 -0.090225994 0.70869612 1 22.99791334 21.24217005 1604 CD55 molecule (Cromer blood group) "GO:0000139,GO:0001618,GO:0005515,GO:0005576,GO:0005886,GO:0006888,GO:0006958,GO:0007204,GO:0008289,GO:0009986,GO:0030133,GO:0030449,GO:0030667,GO:0031225,GO:0031664,GO:0033116,GO:0035743,GO:0043312,GO:0045087,GO:0045121,GO:0045730,GO:0045916,GO:0046718,GO:0070062,GO:0101003,GO:1903659,GO:2000516,GO:2000563" "Golgi membrane|virus receptor activity|protein binding|extracellular region|plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|complement activation, classical pathway|positive regulation of cytosolic calcium ion concentration|lipid binding|cell surface|transport vesicle|regulation of complement activation|secretory granule membrane|anchored component of membrane|regulation of lipopolysaccharide-mediated signaling pathway|endoplasmic reticulum-Golgi intermediate compartment membrane|CD4-positive, alpha-beta T cell cytokine production|neutrophil degranulation|innate immune response|membrane raft|respiratory burst|negative regulation of complement activation|viral entry into host cell|extracellular exosome|ficolin-1-rich granule membrane|regulation of complement-dependent cytotoxicity|positive regulation of CD4-positive, alpha-beta T cell activation|positive regulation of CD4-positive, alpha-beta T cell proliferation" "hsa04610,hsa04640,hsa05416" Complement and coagulation cascades|Hematopoietic cell lineage|Viral myocarditis CD58 243.1706137 302.7604398 183.5807876 0.606356589 -0.721761625 0.032776978 0.920517339 2.537736489 1.513023955 965 CD58 molecule "GO:0005102,GO:0005515,GO:0005886,GO:0005887,GO:0009986,GO:0016020,GO:0030667,GO:0032757,GO:0034113,GO:0043312,GO:0050900,GO:0070062,GO:0071346,GO:0071356,GO:0098609,GO:0101003" signaling receptor binding|protein binding|plasma membrane|integral component of plasma membrane|cell surface|membrane|secretory granule membrane|positive regulation of interleukin-8 production|heterotypic cell-cell adhesion|neutrophil degranulation|leukocyte migration|extracellular exosome|cellular response to interferon-gamma|cellular response to tumor necrosis factor|cell-cell adhesion|ficolin-1-rich granule membrane "hsa04514,hsa05169" Cell adhesion molecules|Epstein-Barr virus infection CD59 18300.31529 14645.90623 21954.72435 1.499034884 0.584033957 0.030799793 0.895820653 97.44733789 143.6325588 966 CD59 molecule (CD59 blood group) "GO:0000139,GO:0001848,GO:0001971,GO:0005515,GO:0005615,GO:0005789,GO:0005886,GO:0005925,GO:0006888,GO:0007166,GO:0007596,GO:0009986,GO:0012507,GO:0016020,GO:0030133,GO:0030449,GO:0031362,GO:0031982,GO:0033116,GO:0035579,GO:0043312,GO:0048208,GO:0070062,GO:0070821,GO:1903659" Golgi membrane|complement binding|negative regulation of activation of membrane attack complex|protein binding|extracellular space|endoplasmic reticulum membrane|plasma membrane|focal adhesion|endoplasmic reticulum to Golgi vesicle-mediated transport|cell surface receptor signaling pathway|blood coagulation|cell surface|ER to Golgi transport vesicle membrane|membrane|transport vesicle|regulation of complement activation|anchored component of external side of plasma membrane|vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|specific granule membrane|neutrophil degranulation|COPII vesicle coating|extracellular exosome|tertiary granule membrane|regulation of complement-dependent cytotoxicity "hsa04610,hsa04640" Complement and coagulation cascades|Hematopoietic cell lineage CD63 8053.611696 7042.561572 9064.661821 1.287125676 0.364152926 0.140381094 1 204.8221076 259.2202726 967 CD63 molecule "GO:0002092,GO:0002576,GO:0005515,GO:0005615,GO:0005654,GO:0005765,GO:0005886,GO:0005887,GO:0007160,GO:0009986,GO:0010008,GO:0015031,GO:0016477,GO:0031088,GO:0031226,GO:0031902,GO:0031904,GO:0032585,GO:0034613,GO:0035577,GO:0035646,GO:0042470,GO:0043231,GO:0043312,GO:0048757,GO:0070062,GO:0097487,GO:1900746,GO:1901379,GO:2001046" "positive regulation of receptor internalization|platelet degranulation|protein binding|extracellular space|nucleoplasm|lysosomal membrane|plasma membrane|integral component of plasma membrane|cell-matrix adhesion|cell surface|endosome membrane|protein transport|cell migration|platelet dense granule membrane|intrinsic component of plasma membrane|late endosome membrane|endosome lumen|multivesicular body membrane|cellular protein localization|azurophil granule membrane|endosome to melanosome transport|melanosome|intracellular membrane-bounded organelle|neutrophil degranulation|pigment granule maturation|extracellular exosome|multivesicular body, internal vesicle|regulation of vascular endothelial growth factor signaling pathway|regulation of potassium ion transmembrane transport|positive regulation of integrin-mediated signaling pathway" "hsa04142,hsa05205" Lysosome|Proteoglycans in cancer CD68 1484.630136 1479.468541 1489.791732 1.006977634 0.010031641 0.96961949 1 46.30880756 45.85161124 968 CD68 molecule "GO:0002437,GO:0002605,GO:0005515,GO:0005764,GO:0005765,GO:0005886,GO:0007568,GO:0016020,GO:0016021,GO:0031669,GO:0031902,GO:0035425,GO:0035577,GO:0043312,GO:0071222,GO:0072594,GO:0140052" inflammatory response to antigenic stimulus|negative regulation of dendritic cell antigen processing and presentation|protein binding|lysosome|lysosomal membrane|plasma membrane|aging|membrane|integral component of membrane|cellular response to nutrient levels|late endosome membrane|autocrine signaling|azurophil granule membrane|neutrophil degranulation|cellular response to lipopolysaccharide|establishment of protein localization to organelle|cellular response to oxidised low-density lipoprotein particle stimulus hsa04142 Lysosome CD69 120.6439654 151.9004269 89.38750391 0.588461177 -0.764980858 0.080689579 1 4.836901313 2.798699182 969 CD69 molecule "GO:0004888,GO:0005509,GO:0005515,GO:0005887,GO:0009897,GO:0030246,GO:0032991,GO:0042802" transmembrane signaling receptor activity|calcium ion binding|protein binding|integral component of plasma membrane|external side of plasma membrane|carbohydrate binding|protein-containing complex|identical protein binding CD7 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.042975988 0.156150998 924 CD7 molecule "GO:0002250,GO:0005515,GO:0005886,GO:0006955,GO:0007169,GO:0016020,GO:0016021,GO:0038023,GO:0042110" adaptive immune response|protein binding|plasma membrane|immune response|transmembrane receptor protein tyrosine kinase signaling pathway|membrane|integral component of membrane|signaling receptor activity|T cell activation hsa04640 Hematopoietic cell lineage CD70 605.3912022 538.9343912 671.8480132 1.246623011 0.318025248 0.226128096 1 10.48940114 12.85751418 970 CD70 molecule "GO:0002020,GO:0002456,GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005886,GO:0005887,GO:0007165,GO:0007267,GO:0019724,GO:0033209,GO:0042100,GO:0042102,GO:0070062,GO:0097191" protease binding|T cell mediated immunity|signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|plasma membrane|integral component of plasma membrane|signal transduction|cell-cell signaling|B cell mediated immunity|tumor necrosis factor-mediated signaling pathway|B cell proliferation|positive regulation of T cell proliferation|extracellular exosome|extrinsic apoptotic signaling pathway hsa04060 Cytokine-cytokine receptor interaction CD72 11.44958313 10.40413883 12.49502743 1.200967003 0.264196513 0.886277421 1 0.362434574 0.427988277 971 CD72 molecule "GO:0004888,GO:0005102,GO:0005515,GO:0005886,GO:0005887,GO:0007155,GO:0030246" transmembrane signaling receptor activity|signaling receptor binding|protein binding|plasma membrane|integral component of plasma membrane|cell adhesion|carbohydrate binding hsa04662 B cell receptor signaling pathway CD74 189.3861235 202.8807071 175.8915399 0.866970263 -0.205945585 0.586317109 1 3.176113365 2.707518141 972 CD74 molecule "GO:0000139,GO:0000187,GO:0001516,GO:0001540,GO:0001934,GO:0001961,GO:0002286,GO:0002606,GO:0002792,GO:0002830,GO:0002906,GO:0004896,GO:0005515,GO:0005634,GO:0005737,GO:0005765,GO:0005771,GO:0005773,GO:0005886,GO:0006886,GO:0008283,GO:0009897,GO:0009986,GO:0010628,GO:0012507,GO:0016020,GO:0016021,GO:0016064,GO:0019882,GO:0019883,GO:0019886,GO:0019955,GO:0023026,GO:0030336,GO:0030658,GO:0030666,GO:0030669,GO:0030890,GO:0031394,GO:0032588,GO:0032722,GO:0032755,GO:0032757,GO:0032991,GO:0033674,GO:0034341,GO:0035691,GO:0035692,GO:0035693,GO:0035718,GO:0042289,GO:0042609,GO:0042613,GO:0042658,GO:0042802,GO:0043030,GO:0043066,GO:0043123,GO:0043202,GO:0043410,GO:0043518,GO:0044183,GO:0045058,GO:0045059,GO:0045060,GO:0045581,GO:0045582,GO:0045657,GO:0045893,GO:0046598,GO:0048146,GO:0050731,GO:0050900,GO:0050998,GO:0051085,GO:0060907,GO:0065003,GO:0070062,GO:0070206,GO:0070374,GO:0071556,GO:0090023,GO:1902166,GO:2000343,GO:2000448" "Golgi membrane|activation of MAPK activity|prostaglandin biosynthetic process|amyloid-beta binding|positive regulation of protein phosphorylation|positive regulation of cytokine-mediated signaling pathway|T cell activation involved in immune response|positive regulation of dendritic cell antigen processing and presentation|negative regulation of peptide secretion|positive regulation of type 2 immune response|negative regulation of mature B cell apoptotic process|cytokine receptor activity|protein binding|nucleus|cytoplasm|lysosomal membrane|multivesicular body|vacuole|plasma membrane|intracellular protein transport|cell population proliferation|external side of plasma membrane|cell surface|positive regulation of gene expression|ER to Golgi transport vesicle membrane|membrane|integral component of membrane|immunoglobulin mediated immune response|antigen processing and presentation|antigen processing and presentation of endogenous antigen|antigen processing and presentation of exogenous peptide antigen via MHC class II|cytokine binding|MHC class II protein complex binding|negative regulation of cell migration|transport vesicle membrane|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|positive regulation of B cell proliferation|positive regulation of prostaglandin biosynthetic process|trans-Golgi network membrane|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|protein-containing complex|positive regulation of kinase activity|response to interferon-gamma|macrophage migration inhibitory factor signaling pathway|macrophage migration inhibitory factor receptor complex|NOS2-CD74 complex|macrophage migration inhibitory factor binding|MHC class II protein binding|CD4 receptor binding|MHC class II protein complex|MHC class II protein binding, via antigen binding groove|identical protein binding|regulation of macrophage activation|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|lysosomal lumen|positive regulation of MAPK cascade|negative regulation of DNA damage response, signal transduction by p53 class mediator|protein folding chaperone|T cell selection|positive thymic T cell selection|negative thymic T cell selection|negative regulation of T cell differentiation|positive regulation of T cell differentiation|positive regulation of monocyte differentiation|positive regulation of transcription, DNA-templated|positive regulation of viral entry into host cell|positive regulation of fibroblast proliferation|positive regulation of peptidyl-tyrosine phosphorylation|leukocyte migration|nitric-oxide synthase binding|chaperone cofactor-dependent protein refolding|positive regulation of macrophage cytokine production|protein-containing complex assembly|extracellular exosome|protein trimerization|positive regulation of ERK1 and ERK2 cascade|integral component of lumenal side of endoplasmic reticulum membrane|positive regulation of neutrophil chemotaxis|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of chemokine (C-X-C motif) ligand 2 production|positive regulation of macrophage migration inhibitory factor signaling pathway" "hsa04612,hsa05152,hsa05168" Antigen processing and presentation|Tuberculosis|Herpes simplex virus 1 infection CD81 2525.730114 2354.456616 2697.003613 1.14548877 0.195963314 0.407412289 1 57.16698012 64.38834543 975 CD81 molecule "GO:0000187,GO:0001618,GO:0001771,GO:0001772,GO:0002455,GO:0002863,GO:0005178,GO:0005515,GO:0005886,GO:0005887,GO:0005925,GO:0008104,GO:0008284,GO:0009925,GO:0014905,GO:0015485,GO:0016020,GO:0016021,GO:0016323,GO:0023026,GO:0030449,GO:0030890,GO:0031623,GO:0031647,GO:0031982,GO:0034238,GO:0035783,GO:0042289,GO:0043128,GO:0045944,GO:0046718,GO:0046813,GO:0050731,GO:0050776,GO:0050861,GO:0050862,GO:0061462,GO:0070062,GO:0070863,GO:0071404,GO:0072659,GO:0072675,GO:0097197,GO:1903911,GO:1904352,GO:1905521,GO:1905676,GO:1990459,GO:2000553,GO:2000563,GO:2001190" "activation of MAPK activity|virus receptor activity|immunological synapse formation|immunological synapse|humoral immune response mediated by circulating immunoglobulin|positive regulation of inflammatory response to antigenic stimulus|integrin binding|protein binding|plasma membrane|integral component of plasma membrane|focal adhesion|protein localization|positive regulation of cell population proliferation|basal plasma membrane|myoblast fusion involved in skeletal muscle regeneration|cholesterol binding|membrane|integral component of membrane|basolateral plasma membrane|MHC class II protein complex binding|regulation of complement activation|positive regulation of B cell proliferation|receptor internalization|regulation of protein stability|vesicle|macrophage fusion|CD4-positive, alpha-beta T cell costimulation|MHC class II protein binding|positive regulation of 1-phosphatidylinositol 4-kinase activity|positive regulation of transcription by RNA polymerase II|viral entry into host cell|receptor-mediated virion attachment to host cell|positive regulation of peptidyl-tyrosine phosphorylation|regulation of immune response|positive regulation of B cell receptor signaling pathway|positive regulation of T cell receptor signaling pathway|protein localization to lysosome|extracellular exosome|positive regulation of protein exit from endoplasmic reticulum|cellular response to low-density lipoprotein particle stimulus|protein localization to plasma membrane|osteoclast fusion|tetraspanin-enriched microdomain|positive regulation of receptor clustering|positive regulation of protein catabolic process in the vacuole|regulation of macrophage migration|positive regulation of adaptive immune memory response|transferrin receptor binding|positive regulation of T-helper 2 cell cytokine production|positive regulation of CD4-positive, alpha-beta T cell proliferation|positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" "hsa04662,hsa05144,hsa05160" B cell receptor signaling pathway|Malaria|Hepatitis C CD82 983.3217946 846.8969005 1119.746689 1.32217592 0.402914145 0.101774211 1 18.72300375 24.34086156 3732 CD82 molecule "GO:0005515,GO:0005886,GO:0005887,GO:0070062" protein binding|plasma membrane|integral component of plasma membrane|extracellular exosome hsa04115 p53 signaling pathway CD83 221.3766424 222.6485709 220.1047139 0.988574564 -0.016578308 0.97666245 1 5.009420328 4.869317399 9308 CD83 molecule "GO:0005515,GO:0005886,GO:0005887,GO:0006952,GO:0006959,GO:0007165,GO:0009897,GO:0014070,GO:0032713,GO:0032733,GO:0032743,GO:0043372" "protein binding|plasma membrane|integral component of plasma membrane|defense response|humoral immune response|signal transduction|external side of plasma membrane|response to organic cyclic compound|negative regulation of interleukin-4 production|positive regulation of interleukin-10 production|positive regulation of interleukin-2 production|positive regulation of CD4-positive, alpha-beta T cell differentiation" CD8A 74.45940408 74.90979955 74.00900861 0.987974992 -0.017453571 1 1 1.276436246 1.239984506 925 CD8a molecule "GO:0002456,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0006955,GO:0007166,GO:0007169,GO:0009897,GO:0015026,GO:0019882,GO:0023024,GO:0042101,GO:0042110,GO:0042288,GO:0044853,GO:0045065,GO:0050776" T cell mediated immunity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|immune response|cell surface receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|external side of plasma membrane|coreceptor activity|antigen processing and presentation|MHC class I protein complex binding|T cell receptor complex|T cell activation|MHC class I protein binding|plasma membrane raft|cytotoxic T cell differentiation|regulation of immune response "hsa04514,hsa04612,hsa04640,hsa04660,hsa05135,hsa05340" Cell adhesion molecules|Antigen processing and presentation|Hematopoietic cell lineage|T cell receptor signaling pathway|Yersinia infection|Primary immunodeficiency CD9 3566.736358 3163.898617 3969.574098 1.254646428 0.327280855 0.168222792 1 123.5197178 152.3802998 928 CD9 molecule "GO:0002576,GO:0005178,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0005925,GO:0007155,GO:0007342,GO:0008347,GO:0014905,GO:0016020,GO:0030168,GO:0030666,GO:0030669,GO:0030913,GO:0031092,GO:0031623,GO:0032991,GO:0035036,GO:0051271,GO:0070062,GO:0071404,GO:0090331,GO:1903561" platelet degranulation|integrin binding|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|focal adhesion|cell adhesion|fusion of sperm to egg plasma membrane involved in single fertilization|glial cell migration|myoblast fusion involved in skeletal muscle regeneration|membrane|platelet activation|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|paranodal junction assembly|platelet alpha granule membrane|receptor internalization|protein-containing complex|sperm-egg recognition|negative regulation of cellular component movement|extracellular exosome|cellular response to low-density lipoprotein particle stimulus|negative regulation of platelet aggregation|extracellular vesicle hsa04640 Hematopoietic cell lineage CD93 5.003924597 5.202069413 4.80577978 0.923820772 -0.11431511 1 1 0.041554391 0.037746424 22918 CD93 molecule "GO:0001849,GO:0005509,GO:0005515,GO:0005886,GO:0006909,GO:0009986,GO:0016021,GO:0016032,GO:0030246,GO:0030667,GO:0035579,GO:0038023,GO:0042116,GO:0043312,GO:0070821,GO:0098609,GO:0101003" complement component C1q complex binding|calcium ion binding|protein binding|plasma membrane|phagocytosis|cell surface|integral component of membrane|viral process|carbohydrate binding|secretory granule membrane|specific granule membrane|signaling receptor activity|macrophage activation|neutrophil degranulation|tertiary granule membrane|cell-cell adhesion|ficolin-1-rich granule membrane CD99-2 214.2283378 72.82897178 355.6277037 4.883052651 2.287783334 1.25E-09 2.14E-06 0.92321814 4.432685457 4267 CD99 molecule (Xg blood group) CD99L2 1974.281918 1919.563613 2029.000223 1.057011192 0.079990652 0.736883177 1 18.93946793 19.68423488 83692 CD99 molecule like 2 "GO:0005515,GO:0005886,GO:0005912,GO:0005925,GO:0007155,GO:0009986,GO:0016021,GO:0050904,GO:2000391,GO:2000409" protein binding|plasma membrane|adherens junction|focal adhesion|cell adhesion|cell surface|integral component of membrane|diapedesis|positive regulation of neutrophil extravasation|positive regulation of T cell extravasation "hsa04514,hsa04670" Cell adhesion molecules|Leukocyte transendothelial migration CDA 335.5755636 268.4267817 402.7243456 1.500313579 0.585264068 0.054338659 1 17.70759455 26.12238272 978 cytidine deaminase "GO:0001882,GO:0004126,GO:0005515,GO:0005576,GO:0005829,GO:0007166,GO:0008270,GO:0008655,GO:0009972,GO:0019858,GO:0030308,GO:0034774,GO:0042802,GO:0042803,GO:0043097,GO:0043312,GO:0045980,GO:1904724,GO:1904813" nucleoside binding|cytidine deaminase activity|protein binding|extracellular region|cytosol|cell surface receptor signaling pathway|zinc ion binding|pyrimidine-containing compound salvage|cytidine deamination|cytosine metabolic process|negative regulation of cell growth|secretory granule lumen|identical protein binding|protein homodimerization activity|pyrimidine nucleoside salvage|neutrophil degranulation|negative regulation of nucleotide metabolic process|tertiary granule lumen|ficolin-1-rich granule lumen "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes CDADC1 129.1805125 136.2942186 122.0668064 0.895612504 -0.159053425 0.723444951 1 1.77886328 1.566512617 81602 cytidine and dCMP deaminase domain containing 1 "GO:0004126,GO:0005634,GO:0005737,GO:0008270,GO:0009972,GO:0042803,GO:0061676,GO:0070383" cytidine deaminase activity|nucleus|cytoplasm|zinc ion binding|cytidine deamination|protein homodimerization activity|importin-alpha family protein binding|DNA cytosine deamination CDAN1 291.4315868 295.4775427 287.3856308 0.972614122 -0.040060555 0.910699696 1 3.457376318 3.30642292 146059 codanin 1 "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006325,GO:0008104,GO:0008156,GO:0012505,GO:0016021,GO:0031497" protein binding|nucleus|cytoplasm|cytosol|plasma membrane|chromatin organization|protein localization|negative regulation of DNA replication|endomembrane system|integral component of membrane|chromatin assembly CDC123 2033.379147 1755.17822 2311.580074 1.317005902 0.39726181 0.093225479 1 70.90888397 91.82470668 8872 cell division cycle 123 "GO:0005737,GO:0007050,GO:0008284,GO:0045948,GO:0051301,GO:1905143" cytoplasm|cell cycle arrest|positive regulation of cell population proliferation|positive regulation of translational initiation|cell division|eukaryotic translation initiation factor 2 complex assembly CDC14A 284.743124 296.5179566 272.9682915 0.920579295 -0.119386099 0.718017676 1 2.96008574 2.679394566 8556 cell division cycle 14A "GO:0000226,GO:0000278,GO:0000922,GO:0004722,GO:0004725,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0007096,GO:0007605,GO:0008138,GO:0016604,GO:0032426,GO:0032467,GO:0035335,GO:0051301,GO:0060091,GO:0060271,GO:0071850,GO:0072686,GO:0106306,GO:0106307,GO:1902636" microtubule cytoskeleton organization|mitotic cell cycle|spindle pole|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleoplasm|nucleolus|cytoplasm|centrosome|cytosol|regulation of exit from mitosis|sensory perception of sound|protein tyrosine/serine/threonine phosphatase activity|nuclear body|stereocilium tip|positive regulation of cytokinesis|peptidyl-tyrosine dephosphorylation|cell division|kinocilium|cilium assembly|mitotic cell cycle arrest|mitotic spindle|protein serine phosphatase activity|protein threonine phosphatase activity|kinociliary basal body hsa04110 Cell cycle CDC14B 1205.440098 1316.123562 1094.756634 0.831803841 -0.265684748 0.272498275 1 8.778789595 7.18003796 8555 cell division cycle 14B "GO:0000226,GO:0000278,GO:0000922,GO:0004722,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0006281,GO:0006470,GO:0007096,GO:0008138,GO:0031572,GO:0032467,GO:0035335,GO:0060271,GO:0071850,GO:0072425,GO:0072686,GO:0106306,GO:0106307,GO:1904668" microtubule cytoskeleton organization|mitotic cell cycle|spindle pole|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|DNA repair|protein dephosphorylation|regulation of exit from mitosis|protein tyrosine/serine/threonine phosphatase activity|G2 DNA damage checkpoint|positive regulation of cytokinesis|peptidyl-tyrosine dephosphorylation|cilium assembly|mitotic cell cycle arrest|signal transduction involved in G2 DNA damage checkpoint|mitotic spindle|protein serine phosphatase activity|protein threonine phosphatase activity|positive regulation of ubiquitin protein ligase activity hsa04110 Cell cycle CDC14C 14.61045374 17.687036 11.53387147 0.65210878 -0.61681545 0.556527256 1 0.324595806 0.208129735 168448 cell division cycle 14C "GO:0000226,GO:0000278,GO:0000922,GO:0004722,GO:0004725,GO:0005730,GO:0005737,GO:0005789,GO:0005813,GO:0007096,GO:0008138,GO:0016021,GO:0031572,GO:0032467,GO:0035335,GO:0060271,GO:0071850,GO:0072686,GO:0106306,GO:0106307" microtubule cytoskeleton organization|mitotic cell cycle|spindle pole|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|nucleolus|cytoplasm|endoplasmic reticulum membrane|centrosome|regulation of exit from mitosis|protein tyrosine/serine/threonine phosphatase activity|integral component of membrane|G2 DNA damage checkpoint|positive regulation of cytokinesis|peptidyl-tyrosine dephosphorylation|cilium assembly|mitotic cell cycle arrest|mitotic spindle|protein serine phosphatase activity|protein threonine phosphatase activity CDC16 1529.388055 1519.004269 1539.771842 1.013671833 0.019590669 0.937421813 1 34.35019746 34.23716497 8881 cell division cycle 16 "GO:0005515,GO:0005654,GO:0005680,GO:0005737,GO:0005813,GO:0005829,GO:0006511,GO:0007091,GO:0016567,GO:0031145,GO:0045842,GO:0051301,GO:0070979,GO:0072686,GO:1901990" protein binding|nucleoplasm|anaphase-promoting complex|cytoplasm|centrosome|cytosol|ubiquitin-dependent protein catabolic process|metaphase/anaphase transition of mitotic cell cycle|protein ubiquitination|anaphase-promoting complex-dependent catabolic process|positive regulation of mitotic metaphase/anaphase transition|cell division|protein K11-linked ubiquitination|mitotic spindle|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection CDC20 3317.485694 3837.046399 2797.924988 0.729187166 -0.455638926 0.054841292 1 124.1819977 89.03665515 991 cell division cycle 20 "GO:0000922,GO:0005515,GO:0005654,GO:0005680,GO:0005813,GO:0005819,GO:0005829,GO:0006511,GO:0007064,GO:0007094,GO:0007399,GO:0008022,GO:0008284,GO:0010997,GO:0016567,GO:0016579,GO:0019899,GO:0030154,GO:0031145,GO:0031915,GO:0040020,GO:0042826,GO:0048471,GO:0050773,GO:0051301,GO:0090129,GO:0090307,GO:1901990,GO:1904668,GO:1905786,GO:1990757" spindle pole|protein binding|nucleoplasm|anaphase-promoting complex|centrosome|spindle|cytosol|ubiquitin-dependent protein catabolic process|mitotic sister chromatid cohesion|mitotic spindle assembly checkpoint|nervous system development|protein C-terminus binding|positive regulation of cell population proliferation|anaphase-promoting complex binding|protein ubiquitination|protein deubiquitination|enzyme binding|cell differentiation|anaphase-promoting complex-dependent catabolic process|positive regulation of synaptic plasticity|regulation of meiotic nuclear division|histone deacetylase binding|perinuclear region of cytoplasm|regulation of dendrite development|cell division|positive regulation of synapse maturation|mitotic spindle assembly|regulation of mitotic cell cycle phase transition|positive regulation of ubiquitin protein ligase activity|positive regulation of anaphase-promoting complex-dependent catabolic process|ubiquitin ligase activator activity "hsa04110,hsa04114,hsa04120,hsa05166,hsa05203" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Human T-cell leukemia virus 1 infection|Viral carcinogenesis CDC20B 15.01177379 15.60620824 14.41733934 0.923820772 -0.11431511 0.982892021 1 0.201226057 0.18278608 166979 cell division cycle 20B "GO:0005515,GO:0005680,GO:0010997,GO:0031145,GO:1904668,GO:1905786,GO:1990757" protein binding|anaphase-promoting complex|anaphase-promoting complex binding|anaphase-promoting complex-dependent catabolic process|positive regulation of ubiquitin protein ligase activity|positive regulation of anaphase-promoting complex-dependent catabolic process|ubiquitin ligase activator activity CDC23 1118.63032 1080.990024 1156.270615 1.069640412 0.097125878 0.692422325 1 18.41380492 19.36656149 8697 cell division cycle 23 "GO:0000278,GO:0004842,GO:0005515,GO:0005654,GO:0005680,GO:0005737,GO:0005829,GO:0006511,GO:0007080,GO:0007091,GO:0007096,GO:0016567,GO:0030071,GO:0031145,GO:0045842,GO:0051301,GO:0070979,GO:1901990" mitotic cell cycle|ubiquitin-protein transferase activity|protein binding|nucleoplasm|anaphase-promoting complex|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|mitotic metaphase plate congression|metaphase/anaphase transition of mitotic cell cycle|regulation of exit from mitosis|protein ubiquitination|regulation of mitotic metaphase/anaphase transition|anaphase-promoting complex-dependent catabolic process|positive regulation of mitotic metaphase/anaphase transition|cell division|protein K11-linked ubiquitination|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection CDC25A 371.9648974 403.6805865 340.2492084 0.842867405 -0.246622402 0.405554033 1 5.630865386 4.666653794 993 cell division cycle 25A "GO:0000079,GO:0000082,GO:0000086,GO:0004721,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008283,GO:0009314,GO:0010971,GO:0016579,GO:0019901,GO:0034644,GO:0035335,GO:0051087,GO:0051301,GO:0051726,GO:0110032" regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cell population proliferation|response to radiation|positive regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|protein kinase binding|cellular response to UV|peptidyl-tyrosine dephosphorylation|chaperone binding|cell division|regulation of cell cycle|positive regulation of G2/MI transition of meiotic cell cycle "hsa04110,hsa04218,hsa04914,hsa05206" Cell cycle|Cellular senescence|Progesterone-mediated oocyte maturation|MicroRNAs in cancer CDC25B 3769.097588 4262.575677 3275.619498 0.768460139 -0.379957667 0.110175187 1 62.51328101 47.23509761 994 cell division cycle 25B "GO:0000086,GO:0000278,GO:0000922,GO:0001556,GO:0004721,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006468,GO:0007144,GO:0008284,GO:0010971,GO:0019901,GO:0032467,GO:0035335,GO:0045860,GO:0045931,GO:0051301,GO:0110032" G2/M transition of mitotic cell cycle|mitotic cell cycle|spindle pole|oocyte maturation|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|protein phosphorylation|female meiosis I|positive regulation of cell population proliferation|positive regulation of G2/M transition of mitotic cell cycle|protein kinase binding|positive regulation of cytokinesis|peptidyl-tyrosine dephosphorylation|positive regulation of protein kinase activity|positive regulation of mitotic cell cycle|cell division|positive regulation of G2/MI transition of meiotic cell cycle "hsa04010,hsa04110,hsa04914,hsa05206" MAPK signaling pathway|Cell cycle|Progesterone-mediated oocyte maturation|MicroRNAs in cancer CDC25C 566.1171718 605.5208797 526.7134639 0.869851861 -0.20115837 0.451504566 1 16.37058584 14.0016977 995 cell division cycle 25C "GO:0000079,GO:0000086,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005758,GO:0005829,GO:0006977,GO:0007088,GO:0007283,GO:0008283,GO:0010971,GO:0016032,GO:0016607,GO:0019901,GO:0035335,GO:0048471,GO:0050699,GO:0051301,GO:0110032" "regulation of cyclin-dependent protein serine/threonine kinase activity|G2/M transition of mitotic cell cycle|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrial intermembrane space|cytosol|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|regulation of mitotic nuclear division|spermatogenesis|cell population proliferation|positive regulation of G2/M transition of mitotic cell cycle|viral process|nuclear speck|protein kinase binding|peptidyl-tyrosine dephosphorylation|perinuclear region of cytoplasm|WW domain binding|cell division|positive regulation of G2/MI transition of meiotic cell cycle" "hsa04110,hsa04114,hsa04914,hsa05170,hsa05206" Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Human immunodeficiency virus 1 infection|MicroRNAs in cancer CDC26 297.7338207 259.0630568 336.4045846 1.298543253 0.37689407 0.232892487 1 9.083915376 11.59846933 246184 cell division cycle 26 "GO:0005515,GO:0005654,GO:0005680,GO:0005829,GO:0006511,GO:0007049,GO:0007346,GO:0030071,GO:0031145,GO:0051301,GO:0070979,GO:1901990" protein binding|nucleoplasm|anaphase-promoting complex|cytosol|ubiquitin-dependent protein catabolic process|cell cycle|regulation of mitotic cell cycle|regulation of mitotic metaphase/anaphase transition|anaphase-promoting complex-dependent catabolic process|cell division|protein K11-linked ubiquitination|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection CDC27 2771.496118 2775.824239 2767.167997 0.99688156 -0.004505988 0.986520001 1 25.13840792 24.64066988 996 cell division cycle 27 "GO:0005515,GO:0005634,GO:0005654,GO:0005680,GO:0005737,GO:0005813,GO:0005819,GO:0005829,GO:0006511,GO:0007091,GO:0016567,GO:0019903,GO:0031145,GO:0045842,GO:0051301,GO:0070979,GO:0072686,GO:1901990" protein binding|nucleus|nucleoplasm|anaphase-promoting complex|cytoplasm|centrosome|spindle|cytosol|ubiquitin-dependent protein catabolic process|metaphase/anaphase transition of mitotic cell cycle|protein ubiquitination|protein phosphatase binding|anaphase-promoting complex-dependent catabolic process|positive regulation of mitotic metaphase/anaphase transition|cell division|protein K11-linked ubiquitination|mitotic spindle|regulation of mitotic cell cycle phase transition "hsa04110,hsa04114,hsa04120,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection CDC34 1115.162478 1040.413883 1189.911074 1.143690115 0.193696205 0.427381713 1 30.60913821 34.42156791 997 "cell division cycle 34, ubiqiutin conjugating enzyme" "GO:0000082,GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006270,GO:0006464,GO:0006511,GO:0016567,GO:0016607,GO:0035458,GO:0043161,GO:0043525,GO:0043951,GO:0061631,GO:0070848,GO:0070936,GO:0090261" G1/S transition of mitotic cell cycle|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|DNA replication initiation|cellular protein modification process|ubiquitin-dependent protein catabolic process|protein ubiquitination|nuclear speck|cellular response to interferon-beta|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of neuron apoptotic process|negative regulation of cAMP-mediated signaling|ubiquitin conjugating enzyme activity|response to growth factor|protein K48-linked ubiquitination|positive regulation of inclusion body assembly hsa04120 Ubiquitin mediated proteolysis CDC37 4065.037314 3805.833983 4324.240646 1.136213683 0.184234182 0.43954054 1 125.1450184 139.8121003 11140 "cell division cycle 37, HSP90 cochaperone" "GO:0000079,GO:0005515,GO:0005737,GO:0005829,GO:0006457,GO:0006605,GO:0010608,GO:0019887,GO:0019900,GO:0019901,GO:0031072,GO:0038128,GO:0050821,GO:0051082,GO:0051087,GO:0051879,GO:0060334,GO:0060338,GO:0070062,GO:0097110,GO:0098779,GO:0101031,GO:1990565" regulation of cyclin-dependent protein serine/threonine kinase activity|protein binding|cytoplasm|cytosol|protein folding|protein targeting|posttranscriptional regulation of gene expression|protein kinase regulator activity|kinase binding|protein kinase binding|heat shock protein binding|ERBB2 signaling pathway|protein stabilization|unfolded protein binding|chaperone binding|Hsp90 protein binding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|extracellular exosome|scaffold protein binding|positive regulation of mitophagy in response to mitochondrial depolarization|chaperone complex|HSP90-CDC37 chaperone complex hsa04151 PI3K-Akt signaling pathway CDC37L1 168.8898472 182.0724295 155.7072649 0.855194086 -0.225676219 0.568084131 1 2.776248836 2.334502035 55664 cell division cycle 37 like 1 "GO:0002576,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0006457,GO:0031072,GO:0031089,GO:0050821,GO:0051082,GO:0051087" platelet degranulation|protein binding|extracellular region|cytoplasm|cytosol|protein folding|heat shock protein binding|platelet dense granule lumen|protein stabilization|unfolded protein binding|chaperone binding CDC40 521.7706341 538.9343912 504.6068769 0.936304836 -0.094949785 0.731045879 1 7.453210142 6.861701345 51362 cell division cycle 40 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0006405,GO:0006406,GO:0016607,GO:0031124,GO:0071007,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|RNA export from nucleus|mRNA export from nucleus|nuclear speck|mRNA 3'-end processing|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome CDC42 4411.077382 3945.249443 4876.905321 1.236146254 0.305849445 0.200549677 1 18.31831492 22.26519775 998 cell division cycle 42 "GO:0000139,GO:0000322,GO:0002040,GO:0003161,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005789,GO:0005813,GO:0005829,GO:0005886,GO:0005911,GO:0005925,GO:0006897,GO:0006911,GO:0007015,GO:0007030,GO:0007088,GO:0007097,GO:0007163,GO:0007229,GO:0007596,GO:0010591,GO:0010592,GO:0016020,GO:0016477,GO:0016567,GO:0017119,GO:0019901,GO:0021762,GO:0030031,GO:0030036,GO:0030141,GO:0030175,GO:0030225,GO:0030307,GO:0030496,GO:0030742,GO:0031256,GO:0031274,GO:0031295,GO:0031333,GO:0031435,GO:0031996,GO:0032427,GO:0032467,GO:0032488,GO:0032991,GO:0034191,GO:0034329,GO:0034332,GO:0034613,GO:0035722,GO:0036336,GO:0036464,GO:0038096,GO:0038189,GO:0039694,GO:0042059,GO:0042802,GO:0043005,GO:0043025,GO:0043197,GO:0043393,GO:0043525,GO:0043552,GO:0045177,GO:0045198,GO:0045335,GO:0045740,GO:0046330,GO:0046847,GO:0048010,GO:0048013,GO:0048549,GO:0048664,GO:0051056,GO:0051149,GO:0051233,GO:0051489,GO:0051491,GO:0051492,GO:0051496,GO:0051683,GO:0051835,GO:0051988,GO:0060047,GO:0060071,GO:0060501,GO:0060661,GO:0060997,GO:0061630,GO:0070062,GO:0071346,GO:0072384,GO:0072686,GO:0090135,GO:0090316,GO:0098685,GO:0099159,GO:0099563,GO:1900026,GO:2000251" "Golgi membrane|storage vacuole|sprouting angiogenesis|cardiac conduction system development|GTPase activity|protein binding|GTP binding|cytoplasm|endoplasmic reticulum membrane|centrosome|cytosol|plasma membrane|cell-cell junction|focal adhesion|endocytosis|phagocytosis, engulfment|actin filament organization|Golgi organization|regulation of mitotic nuclear division|nuclear migration|establishment or maintenance of cell polarity|integrin-mediated signaling pathway|blood coagulation|regulation of lamellipodium assembly|positive regulation of lamellipodium assembly|membrane|cell migration|protein ubiquitination|Golgi transport complex|protein kinase binding|substantia nigra development|cell projection assembly|actin cytoskeleton organization|secretory granule|filopodium|macrophage differentiation|positive regulation of cell growth|midbody|GTP-dependent protein binding|leading edge membrane|positive regulation of pseudopodium assembly|T cell costimulation|negative regulation of protein-containing complex assembly|mitogen-activated protein kinase kinase kinase binding|thioesterase binding|GBD domain binding|positive regulation of cytokinesis|Cdc42 protein signal transduction|protein-containing complex|apolipoprotein A-I receptor binding|cell junction assembly|adherens junction organization|cellular protein localization|interleukin-12-mediated signaling pathway|dendritic cell migration|cytoplasmic ribonucleoprotein granule|Fc-gamma receptor signaling pathway involved in phagocytosis|neuropilin signaling pathway|viral RNA genome replication|negative regulation of epidermal growth factor receptor signaling pathway|identical protein binding|neuron projection|neuronal cell body|dendritic spine|regulation of protein binding|positive regulation of neuron apoptotic process|positive regulation of phosphatidylinositol 3-kinase activity|apical part of cell|establishment of epithelial cell apical/basal polarity|phagocytic vesicle|positive regulation of DNA replication|positive regulation of JNK cascade|filopodium assembly|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|positive regulation of pinocytosis|neuron fate determination|regulation of small GTPase mediated signal transduction|positive regulation of muscle cell differentiation|spindle midzone|regulation of filopodium assembly|positive regulation of filopodium assembly|regulation of stress fiber assembly|positive regulation of stress fiber assembly|establishment of Golgi localization|positive regulation of synapse structural plasticity|regulation of attachment of spindle microtubules to kinetochore|heart contraction|Wnt signaling pathway, planar cell polarity pathway|positive regulation of epithelial cell proliferation involved in lung morphogenesis|submandibular salivary gland formation|dendritic spine morphogenesis|ubiquitin protein ligase activity|extracellular exosome|cellular response to interferon-gamma|organelle transport along microtubule|mitotic spindle|actin filament branching|positive regulation of intracellular protein transport|Schaffer collateral - CA1 synapse|regulation of modification of postsynaptic structure|modification of synaptic structure|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of actin cytoskeleton reorganization" "hsa04010,hsa04014,hsa04015,hsa04062,hsa04144,hsa04360,hsa04370,hsa04510,hsa04520,hsa04530,hsa04660,hsa04666,hsa04670,hsa04722,hsa04810,hsa04912,hsa04932,hsa04933,hsa05100,hsa05120,hsa05130,hsa05131,hsa05132,hsa05135,hsa05165,hsa05200,hsa05203,hsa05205,hsa05211,hsa05212" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|Endocytosis|Axon guidance|VEGF signaling pathway|Focal adhesion|Adherens junction|Tight junction|T cell receptor signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|GnRH signaling pathway|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Bacterial invasion of epithelial cells|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Human papillomavirus infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|Renal cell carcinoma|Pancreatic cancer CDC42BPA 2275.631421 2349.254547 2202.008295 0.937322138 -0.093383137 0.693922879 1 10.92500849 10.06889556 8476 CDC42 binding protein kinase alpha "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005856,GO:0005911,GO:0006468,GO:0016477,GO:0018107,GO:0030027,GO:0031032,GO:0031252,GO:0031532,GO:0035556,GO:0042641,GO:0042802,GO:0070062,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytoskeleton|cell-cell junction|protein phosphorylation|cell migration|peptidyl-threonine phosphorylation|lamellipodium|actomyosin structure organization|cell leading edge|actin cytoskeleton reorganization|intracellular signal transduction|actomyosin|identical protein binding|extracellular exosome|protein serine kinase activity|protein threonine kinase activity CDC42BPB 4015.298166 4102.351939 3928.244392 0.957559091 -0.062566577 0.793553353 1 31.16068648 29.33889676 9578 CDC42 binding protein kinase beta "GO:0000287,GO:0004672,GO:0004674,GO:0005524,GO:0005737,GO:0005856,GO:0005886,GO:0005911,GO:0006468,GO:0007010,GO:0007163,GO:0007165,GO:0016477,GO:0018107,GO:0030027,GO:0031032,GO:0031252,GO:0031532,GO:0035556,GO:0042641,GO:0044877,GO:0070062,GO:0106310,GO:0106311" magnesium ion binding|protein kinase activity|protein serine/threonine kinase activity|ATP binding|cytoplasm|cytoskeleton|plasma membrane|cell-cell junction|protein phosphorylation|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction|cell migration|peptidyl-threonine phosphorylation|lamellipodium|actomyosin structure organization|cell leading edge|actin cytoskeleton reorganization|intracellular signal transduction|actomyosin|protein-containing complex binding|extracellular exosome|protein serine kinase activity|protein threonine kinase activity CDC42BPG 80.82077427 90.51600779 71.12554074 0.785778587 -0.34780524 0.499628701 1 0.74238097 0.573585547 55561 CDC42 binding protein kinase gamma "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005856,GO:0006468,GO:0018107,GO:0031032,GO:0031252,GO:0031532,GO:0034451,GO:0035556,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytosol|cytoskeleton|protein phosphorylation|peptidyl-threonine phosphorylation|actomyosin structure organization|cell leading edge|actin cytoskeleton reorganization|centriolar satellite|intracellular signal transduction|protein serine kinase activity|protein threonine kinase activity CDC42EP1 1089.12072 1265.143281 913.0981582 0.721734978 -0.47045892 0.053849627 1 31.43313393 22.30676617 11135 CDC42 effector protein 1 "GO:0005515,GO:0005737,GO:0005856,GO:0005886,GO:0005912,GO:0005925,GO:0007266,GO:0008360,GO:0012505,GO:0030838,GO:0031274,GO:0098609,GO:0098641" protein binding|cytoplasm|cytoskeleton|plasma membrane|adherens junction|focal adhesion|Rho protein signal transduction|regulation of cell shape|endomembrane system|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly|cell-cell adhesion|cadherin binding involved in cell-cell adhesion CDC42EP2 631.3763972 653.3799183 609.3728761 0.932647085 -0.100596829 0.703664971 1 17.76346683 16.28981848 10435 CDC42 effector protein 2 "GO:0001515,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0007015,GO:0007266,GO:0008360,GO:0012505,GO:0015630,GO:0016020,GO:0030036,GO:0030838,GO:0031267,GO:0031274,GO:0031334,GO:0043547,GO:0045335,GO:0071346" opioid peptide activity|GTPase activator activity|protein binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|actin filament organization|Rho protein signal transduction|regulation of cell shape|endomembrane system|microtubule cytoskeleton|membrane|actin cytoskeleton organization|positive regulation of actin filament polymerization|small GTPase binding|positive regulation of pseudopodium assembly|positive regulation of protein-containing complex assembly|positive regulation of GTPase activity|phagocytic vesicle|cellular response to interferon-gamma CDC42EP3 1805.817929 1773.90567 1837.730188 1.035979657 0.050995674 0.831739325 1 15.62728381 15.91863796 10602 CDC42 effector protein 3 "GO:0005515,GO:0005519,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0007165,GO:0007266,GO:0008360,GO:0012505,GO:0015629,GO:0030838,GO:0031274" protein binding|cytoskeletal regulatory protein binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|signal transduction|Rho protein signal transduction|regulation of cell shape|endomembrane system|actin cytoskeleton|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly CDC42EP4 1174.21259 1291.153628 1057.271552 0.818858057 -0.288314702 0.234602763 1 19.54794216 15.73913464 23580 CDC42 effector protein 4 "GO:0003723,GO:0005515,GO:0005737,GO:0005856,GO:0005886,GO:0005912,GO:0007266,GO:0008360,GO:0012505,GO:0015629,GO:0015630,GO:0030838,GO:0031267,GO:0031274,GO:0045335,GO:0071346" RNA binding|protein binding|cytoplasm|cytoskeleton|plasma membrane|adherens junction|Rho protein signal transduction|regulation of cell shape|endomembrane system|actin cytoskeleton|microtubule cytoskeleton|positive regulation of actin filament polymerization|small GTPase binding|positive regulation of pseudopodium assembly|phagocytic vesicle|cellular response to interferon-gamma CDC42EP5 38.75823953 20.80827765 56.7082014 2.725271277 1.446399845 0.030496881 0.895820653 1.239396802 3.321171394 148170 CDC42 effector protein 5 "GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0007254,GO:0007266,GO:0008360,GO:0012505,GO:0016020,GO:0030838,GO:0031267,GO:0031274" cytoplasm|cytosol|cytoskeleton|plasma membrane|JNK cascade|Rho protein signal transduction|regulation of cell shape|endomembrane system|membrane|positive regulation of actin filament polymerization|small GTPase binding|positive regulation of pseudopodium assembly CDC42SE1 2849.283741 3039.048951 2659.51853 0.875115397 -0.192454824 0.416174636 1 51.53748236 44.34653611 56882 CDC42 small effector 1 "GO:0005095,GO:0005737,GO:0005856,GO:0005886,GO:0006909,GO:0007165,GO:0008360,GO:0030054,GO:0034260,GO:0035023" GTPase inhibitor activity|cytoplasm|cytoskeleton|plasma membrane|phagocytosis|signal transduction|regulation of cell shape|cell junction|negative regulation of GTPase activity|regulation of Rho protein signal transduction CDC42SE2 753.4325284 779.2699981 727.5950587 0.933688016 -0.098987528 0.699853948 1 11.28887285 10.36390789 56990 CDC42 small effector 2 "GO:0001891,GO:0005515,GO:0005737,GO:0005856,GO:0005886,GO:0006909,GO:0008360,GO:0009966,GO:0035023,GO:0035591,GO:0042995" phagocytic cup|protein binding|cytoplasm|cytoskeleton|plasma membrane|phagocytosis|regulation of cell shape|regulation of signal transduction|regulation of Rho protein signal transduction|signaling adaptor activity|cell projection CDC45 883.3414535 896.8367668 869.8461402 0.969904639 -0.044085187 0.863686152 1 19.82706294 18.90856627 8318 cell division cycle 45 "GO:0000076,GO:0000082,GO:0000083,GO:0000727,GO:0003682,GO:0003688,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0006260,GO:0006270,GO:0031261,GO:0031938,GO:0036064,GO:1902977" DNA replication checkpoint|G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|double-strand break repair via break-induced replication|chromatin binding|DNA replication origin binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|DNA replication|DNA replication initiation|DNA replication preinitiation complex|regulation of chromatin silencing at telomere|ciliary basal body|mitotic DNA replication preinitiation complex assembly hsa04110 Cell cycle CDC5L 1374.182104 1368.144256 1380.219953 1.008826333 0.01267784 0.961167071 1 11.6993021 11.60506411 988 cell division cycle 5 like "GO:0000278,GO:0000398,GO:0000974,GO:0000977,GO:0000981,GO:0001222,GO:0001228,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005662,GO:0005681,GO:0005737,GO:0006281,GO:0006357,GO:0008157,GO:0016020,GO:0016607,GO:0019901,GO:0043522,GO:0044344,GO:0045944,GO:0048471,GO:0071007,GO:0071013,GO:0071352,GO:0071987,GO:0072422,GO:1904568,GO:1990090,GO:1990646" "mitotic cell cycle|mRNA splicing, via spliceosome|Prp19 complex|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|transcription corepressor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|DNA replication factor A complex|spliceosomal complex|cytoplasm|DNA repair|regulation of transcription by RNA polymerase II|protein phosphatase 1 binding|membrane|nuclear speck|protein kinase binding|leucine zipper domain binding|cellular response to fibroblast growth factor stimulus|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|cellular response to interleukin-2|WD40-repeat domain binding|signal transduction involved in DNA damage checkpoint|cellular response to wortmannin|cellular response to nerve growth factor stimulus|cellular response to prolactin" hsa03040 Spliceosome CDC6 1892.479866 1878.987472 1905.972261 1.014361346 0.020571675 0.933122672 1 33.54904916 33.46139832 990 cell division cycle 6 "GO:0000076,GO:0000079,GO:0000082,GO:0000083,GO:0000166,GO:0000278,GO:0000922,GO:0003688,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006260,GO:0006270,GO:0007089,GO:0008156,GO:0008285,GO:0019900,GO:0030071,GO:0032467,GO:0033314,GO:0045171,GO:0045737,GO:0048146,GO:0051233,GO:0051301,GO:0051984,GO:0072686,GO:1904117,GO:1904385" DNA replication checkpoint|regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|nucleotide binding|mitotic cell cycle|spindle pole|DNA replication origin binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|DNA replication|DNA replication initiation|traversing start control point of mitotic cell cycle|negative regulation of DNA replication|negative regulation of cell population proliferation|kinase binding|regulation of mitotic metaphase/anaphase transition|positive regulation of cytokinesis|mitotic DNA replication checkpoint|intercellular bridge|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of fibroblast proliferation|spindle midzone|cell division|positive regulation of chromosome segregation|mitotic spindle|cellular response to vasopressin|cellular response to angiotensin hsa04110 Cell cycle CDC7 803.4472366 792.7953786 814.0990947 1.026871645 0.038255862 0.883993745 1 12.15805525 12.27584661 8317 cell division cycle 7 "GO:0000082,GO:0000727,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006260,GO:0008284,GO:0010571,GO:0010971,GO:0016301,GO:0018105,GO:0044770,GO:0045171,GO:0046872,GO:0051301,GO:0070317,GO:0072686,GO:0106310,GO:0106311" G1/S transition of mitotic cell cycle|double-strand break repair via break-induced replication|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|DNA replication|positive regulation of cell population proliferation|positive regulation of nuclear cell cycle DNA replication|positive regulation of G2/M transition of mitotic cell cycle|kinase activity|peptidyl-serine phosphorylation|cell cycle phase transition|intercellular bridge|metal ion binding|cell division|negative regulation of G0 to G1 transition|mitotic spindle|protein serine kinase activity|protein threonine kinase activity hsa04110 Cell cycle CDC73 1518.195753 1565.822893 1470.568613 0.939166632 -0.090546944 0.706039321 1 13.69246108 12.64431619 79577 cell division cycle 73 "GO:0000122,GO:0000781,GO:0000993,GO:0001558,GO:0001711,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006366,GO:0006368,GO:0006378,GO:0007049,GO:0008285,GO:0010390,GO:0016055,GO:0016567,GO:0016593,GO:0019827,GO:0030177,GO:0031442,GO:0031648,GO:0032968,GO:0033523,GO:0034402,GO:0043066,GO:0045638,GO:0048147,GO:0050680,GO:0071222,GO:1902808,GO:1904837,GO:2000134" "negative regulation of transcription by RNA polymerase II|chromosome, telomeric region|RNA polymerase II complex binding|regulation of cell growth|endodermal cell fate commitment|protein binding|nucleus|nucleoplasm|cytosol|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|mRNA polyadenylation|cell cycle|negative regulation of cell population proliferation|histone monoubiquitination|Wnt signaling pathway|protein ubiquitination|Cdc73/Paf1 complex|stem cell population maintenance|positive regulation of Wnt signaling pathway|positive regulation of mRNA 3'-end processing|protein destabilization|positive regulation of transcription elongation from RNA polymerase II promoter|histone H2B ubiquitination|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|negative regulation of apoptotic process|negative regulation of myeloid cell differentiation|negative regulation of fibroblast proliferation|negative regulation of epithelial cell proliferation|cellular response to lipopolysaccharide|positive regulation of cell cycle G1/S phase transition|beta-catenin-TCF complex assembly|negative regulation of G1/S transition of mitotic cell cycle" CDCA2 735.4674753 837.5331755 633.401775 0.756270669 -0.403025428 0.11297798 1 10.62963288 7.904359806 157313 cell division cycle associated 2 "GO:0005654,GO:0005694,GO:0005829,GO:0007049,GO:0007059,GO:0035307,GO:0051301" nucleoplasm|chromosome|cytosol|cell cycle|chromosome segregation|positive regulation of protein dephosphorylation|cell division CDCA3 894.6073687 965.5040831 823.7106543 0.853140519 -0.229144711 0.357129899 1 15.85451643 13.2997889 83461 cell division cycle associated 3 "GO:0005515,GO:0005829,GO:0005912,GO:0007049,GO:0008150,GO:0016567,GO:0051301" protein binding|cytosol|adherens junction|cell cycle|biological_process|protein ubiquitination|cell division CDCA4 2179.983155 2083.949007 2276.017304 1.092165545 0.12719155 0.591457565 1 45.43158838 48.78851183 55038 cell division cycle associated 4 "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0048096,GO:0140110" protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|chromatin-mediated maintenance of transcription|transcription regulator activity CDCA5 2575.703965 2568.781876 2582.626054 1.005389394 0.007754375 0.975667142 1 37.47708243 37.04855313 113130 cell division cycle associated 5 "GO:0000278,GO:0000775,GO:0000785,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0006302,GO:0007064,GO:0007076,GO:0007080,GO:0031536,GO:0044877,GO:0051301,GO:0071922" "mitotic cell cycle|chromosome, centromeric region|chromatin|chromatin binding|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|cytosol|double-strand break repair|mitotic sister chromatid cohesion|mitotic chromosome condensation|mitotic metaphase plate congression|positive regulation of exit from mitosis|protein-containing complex binding|cell division|regulation of cohesin loading" hsa05206 MicroRNAs in cancer CDCA7 989.4391318 1070.585885 908.2923784 0.848406831 -0.237171858 0.335609144 1 20.56702701 17.15721738 83879 cell division cycle associated 7 "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006915,GO:0042127" "protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|apoptotic process|regulation of cell population proliferation" CDCA7L 3190.56576 2662.419126 3718.712394 1.396741917 0.482065471 0.042138073 1 48.37875908 66.44190407 55536 cell division cycle associated 7 like "GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006355,GO:0008284" "fibrillar center|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription, DNA-templated|positive regulation of cell population proliferation" CDCA8 1066.826663 1134.051132 999.6021942 0.881443672 -0.182059717 0.457461897 1 26.6148745 23.06694954 55143 cell division cycle associated 8 "GO:0000070,GO:0000775,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0007080,GO:0010369,GO:0030496,GO:0032133,GO:0032991,GO:0045171,GO:0051233,GO:0051276,GO:0051301" "mitotic sister chromatid segregation|chromosome, centromeric region|protein binding|nucleoplasm|nucleolus|cytosol|mitotic metaphase plate congression|chromocenter|midbody|chromosome passenger complex|protein-containing complex|intercellular bridge|spindle midzone|chromosome organization|cell division" CDCP1 19990.91335 20498.23432 19483.59238 0.950501008 -0.073239938 0.78868817 1 175.397321 163.9255752 64866 CUB domain containing protein 1 "GO:0005515,GO:0005576,GO:0005886,GO:0016021" protein binding|extracellular region|plasma membrane|integral component of membrane CDH10 17.81598373 13.52538047 22.10658699 1.634452135 0.708807128 0.448206118 1 0.207599855 0.3336341 1008 cadherin 10 "GO:0000902,GO:0005509,GO:0005886,GO:0005912,GO:0007043,GO:0007156,GO:0007275,GO:0016339,GO:0016342,GO:0034332,GO:0045296,GO:0098609,GO:0098742,GO:0098978,GO:0098982,GO:0099059,GO:0099060" cell morphogenesis|calcium ion binding|plasma membrane|adherens junction|cell-cell junction assembly|homophilic cell adhesion via plasma membrane adhesion molecules|multicellular organism development|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|adherens junction organization|cadherin binding|cell-cell adhesion|cell-cell adhesion via plasma-membrane adhesion molecules|glutamatergic synapse|GABA-ergic synapse|integral component of presynaptic active zone membrane|integral component of postsynaptic specialization membrane CDH11 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.022115631 0.020088996 1009 cadherin 11 "GO:0000902,GO:0001501,GO:0001503,GO:0005509,GO:0005737,GO:0005886,GO:0005912,GO:0007043,GO:0007155,GO:0007156,GO:0007275,GO:0016021,GO:0016339,GO:0016342,GO:0021957,GO:0034332,GO:0045296,GO:0050804,GO:0070062,GO:0098685,GO:0098742,GO:0098978" cell morphogenesis|skeletal system development|ossification|calcium ion binding|cytoplasm|plasma membrane|adherens junction|cell-cell junction assembly|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|multicellular organism development|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|corticospinal tract morphogenesis|adherens junction organization|cadherin binding|modulation of chemical synaptic transmission|extracellular exosome|Schaffer collateral - CA1 synapse|cell-cell adhesion via plasma-membrane adhesion molecules|glutamatergic synapse CDH12 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.022873317 0.031165874 1010 cadherin 12 "GO:0000902,GO:0005509,GO:0005886,GO:0005912,GO:0007043,GO:0007156,GO:0007275,GO:0016021,GO:0016339,GO:0016342,GO:0034332,GO:0045296,GO:0098742" cell morphogenesis|calcium ion binding|plasma membrane|adherens junction|cell-cell junction assembly|homophilic cell adhesion via plasma membrane adhesion molecules|multicellular organism development|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|adherens junction organization|cadherin binding|cell-cell adhesion via plasma-membrane adhesion molecules CDH13 2686.553317 2678.025334 2695.081301 1.006368859 0.009159186 0.970847129 1 32.63788309 32.29612005 1012 cadherin 13 "GO:0000278,GO:0001938,GO:0001954,GO:0002040,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005886,GO:0005901,GO:0005925,GO:0007156,GO:0007162,GO:0007266,GO:0008285,GO:0009897,GO:0016339,GO:0016342,GO:0016601,GO:0030032,GO:0030100,GO:0030169,GO:0030335,GO:0031225,GO:0034332,GO:0042058,GO:0042803,GO:0043005,GO:0043542,GO:0043616,GO:0045296,GO:0045944,GO:0048471,GO:0048661,GO:0050850,GO:0050927,GO:0051668,GO:0055096,GO:0055100,GO:0062023,GO:0070062,GO:0071813,GO:0098742,GO:0098982" mitotic cell cycle|positive regulation of endothelial cell proliferation|positive regulation of cell-matrix adhesion|sprouting angiogenesis|calcium ion binding|protein binding|extracellular region|extracellular space|cytoplasm|plasma membrane|caveola|focal adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|negative regulation of cell adhesion|Rho protein signal transduction|negative regulation of cell population proliferation|external side of plasma membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|Rac protein signal transduction|lamellipodium assembly|regulation of endocytosis|low-density lipoprotein particle binding|positive regulation of cell migration|anchored component of membrane|adherens junction organization|regulation of epidermal growth factor receptor signaling pathway|protein homodimerization activity|neuron projection|endothelial cell migration|keratinocyte proliferation|cadherin binding|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|positive regulation of smooth muscle cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of positive chemotaxis|localization within membrane|low-density lipoprotein particle mediated signaling|adiponectin binding|collagen-containing extracellular matrix|extracellular exosome|lipoprotein particle binding|cell-cell adhesion via plasma-membrane adhesion molecules|GABA-ergic synapse CDH15 13.93173094 12.48496659 15.3784953 1.231761029 0.300722389 0.825910327 1 0.232484201 0.281573049 1013 cadherin 15 "GO:0005509,GO:0005515,GO:0005794,GO:0005886,GO:0005901,GO:0007155,GO:0007156,GO:0016021,GO:0016342,GO:0031594,GO:0034332,GO:0045296,GO:0051149,GO:0070062,GO:0098742" calcium ion binding|protein binding|Golgi apparatus|plasma membrane|caveola|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|integral component of membrane|catenin complex|neuromuscular junction|adherens junction organization|cadherin binding|positive regulation of muscle cell differentiation|extracellular exosome|cell-cell adhesion via plasma-membrane adhesion molecules hsa04514 Cell adhesion molecules CDH18 38.15374424 30.1720026 46.13548589 1.529082657 0.612666396 0.364126373 1 0.202365757 0.30425601 1016 cadherin 18 "GO:0000902,GO:0005509,GO:0005886,GO:0005912,GO:0007043,GO:0007156,GO:0007275,GO:0016021,GO:0016339,GO:0016342,GO:0034332,GO:0045296,GO:0098742" cell morphogenesis|calcium ion binding|plasma membrane|adherens junction|cell-cell junction assembly|homophilic cell adhesion via plasma membrane adhesion molecules|multicellular organism development|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|adherens junction organization|cadherin binding|cell-cell adhesion via plasma-membrane adhesion molecules CDH2 2709.038645 3129.564959 2288.512331 0.731255737 -0.451552056 0.056371776 1 36.43523778 26.19763416 1000 cadherin 2 "GO:0003323,GO:0005509,GO:0005515,GO:0005737,GO:0005788,GO:0005886,GO:0005887,GO:0005911,GO:0005912,GO:0005916,GO:0005925,GO:0007043,GO:0007155,GO:0007156,GO:0007157,GO:0007416,GO:0007420,GO:0008013,GO:0009986,GO:0010001,GO:0014032,GO:0014069,GO:0014704,GO:0016323,GO:0016324,GO:0016327,GO:0016339,GO:0016342,GO:0019901,GO:0019903,GO:0021987,GO:0030027,GO:0030054,GO:0030864,GO:0034332,GO:0035995,GO:0042383,GO:0042802,GO:0043005,GO:0043410,GO:0043687,GO:0044267,GO:0044331,GO:0044853,GO:0045177,GO:0045294,GO:0045295,GO:0045296,GO:0048514,GO:0048854,GO:0048872,GO:0050770,GO:0051146,GO:0051149,GO:0051966,GO:0060019,GO:0060563,GO:0062023,GO:0070445,GO:0072659,GO:0090090,GO:0090497,GO:0097118,GO:0097150,GO:0098609,GO:0098742,GO:0099059,GO:0099060,GO:1902897,GO:2000809" "type B pancreatic cell development|calcium ion binding|protein binding|cytoplasm|endoplasmic reticulum lumen|plasma membrane|integral component of plasma membrane|cell-cell junction|adherens junction|fascia adherens|focal adhesion|cell-cell junction assembly|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|synapse assembly|brain development|beta-catenin binding|cell surface|glial cell differentiation|neural crest cell development|postsynaptic density|intercalated disc|basolateral plasma membrane|apical plasma membrane|apicolateral plasma membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|protein kinase binding|protein phosphatase binding|cerebral cortex development|lamellipodium|cell junction|cortical actin cytoskeleton|adherens junction organization|detection of muscle stretch|sarcolemma|identical protein binding|neuron projection|positive regulation of MAPK cascade|post-translational protein modification|cellular protein metabolic process|cell-cell adhesion mediated by cadherin|plasma membrane raft|apical part of cell|alpha-catenin binding|gamma-catenin binding|cadherin binding|blood vessel morphogenesis|brain morphogenesis|homeostasis of number of cells|regulation of axonogenesis|striated muscle cell differentiation|positive regulation of muscle cell differentiation|regulation of synaptic transmission, glutamatergic|radial glial cell differentiation|neuroepithelial cell differentiation|collagen-containing extracellular matrix|regulation of oligodendrocyte progenitor proliferation|protein localization to plasma membrane|negative regulation of canonical Wnt signaling pathway|mesenchymal cell migration|neuroligin clustering involved in postsynaptic membrane assembly|neuronal stem cell population maintenance|cell-cell adhesion|cell-cell adhesion via plasma-membrane adhesion molecules|integral component of presynaptic active zone membrane|integral component of postsynaptic specialization membrane|regulation of postsynaptic density protein 95 clustering|positive regulation of synaptic vesicle clustering" "hsa04514,hsa05412" Cell adhesion molecules|Arrhythmogenic right ventricular cardiomyopathy CDH24 792.5027692 820.8865534 764.118985 0.930846025 -0.10338555 0.684834552 1 8.549806134 7.825377445 64403 cadherin 24 "GO:0000902,GO:0005509,GO:0005886,GO:0005911,GO:0005912,GO:0007043,GO:0007156,GO:0007275,GO:0016021,GO:0016339,GO:0016342,GO:0034332,GO:0045296,GO:0098609,GO:0098742" cell morphogenesis|calcium ion binding|plasma membrane|cell-cell junction|adherens junction|cell-cell junction assembly|homophilic cell adhesion via plasma membrane adhesion molecules|multicellular organism development|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|adherens junction organization|cadherin binding|cell-cell adhesion|cell-cell adhesion via plasma-membrane adhesion molecules CDH4 538.0555651 575.3488771 500.7622531 0.870362789 -0.200311218 0.458402674 1 4.399672177 3.765232612 1002 cadherin 4 "GO:0005509,GO:0005886,GO:0005887,GO:0007155,GO:0007156,GO:0007157,GO:0007411,GO:0016342,GO:0034332,GO:0045296,GO:0045773,GO:0098742" calcium ion binding|plasma membrane|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|axon guidance|catenin complex|adherens junction organization|cadherin binding|positive regulation of axon extension|cell-cell adhesion via plasma-membrane adhesion molecules hsa04514 Cell adhesion molecules CDH6 5.04355356 6.242483296 3.844623824 0.615880514 -0.699277611 0.760739355 1 0.070582598 0.042743027 1004 cadherin 6 "GO:0000902,GO:0005509,GO:0005654,GO:0005886,GO:0005912,GO:0007043,GO:0007155,GO:0007156,GO:0007219,GO:0007275,GO:0016021,GO:0016339,GO:0016342,GO:0030054,GO:0034332,GO:0045296,GO:0098742" cell morphogenesis|calcium ion binding|nucleoplasm|plasma membrane|adherens junction|cell-cell junction assembly|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|Notch signaling pathway|multicellular organism development|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|cell junction|adherens junction organization|cadherin binding|cell-cell adhesion via plasma-membrane adhesion molecules CDH7 4.444088692 3.121241648 5.766935736 1.847641543 0.88568489 0.705170935 1 0.012363611 0.022461266 1005 cadherin 7 "GO:0000902,GO:0005509,GO:0005886,GO:0005912,GO:0007043,GO:0007156,GO:0007275,GO:0016021,GO:0016339,GO:0016342,GO:0034332,GO:0045296,GO:0098609,GO:0098742" cell morphogenesis|calcium ion binding|plasma membrane|adherens junction|cell-cell junction assembly|homophilic cell adhesion via plasma membrane adhesion molecules|multicellular organism development|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|adherens junction organization|cadherin binding|cell-cell adhesion|cell-cell adhesion via plasma-membrane adhesion molecules CDH8 8.045908318 9.363724944 6.728091692 0.718527267 -0.476885189 0.786592357 1 0.030908263 0.021836801 1006 cadherin 8 "GO:0000902,GO:0005509,GO:0005886,GO:0005912,GO:0007043,GO:0007155,GO:0007156,GO:0007275,GO:0009409,GO:0016021,GO:0016339,GO:0016342,GO:0034332,GO:0035249,GO:0042802,GO:0043083,GO:0043679,GO:0045296,GO:0050807,GO:0097060,GO:0098742,GO:0098978" "cell morphogenesis|calcium ion binding|plasma membrane|adherens junction|cell-cell junction assembly|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|multicellular organism development|response to cold|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|adherens junction organization|synaptic transmission, glutamatergic|identical protein binding|synaptic cleft|axon terminus|cadherin binding|regulation of synapse organization|synaptic membrane|cell-cell adhesion via plasma-membrane adhesion molecules|glutamatergic synapse" CDH9 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.072063565 0.032729898 1007 cadherin 9 "GO:0000902,GO:0003674,GO:0005509,GO:0005886,GO:0005912,GO:0007043,GO:0007156,GO:0007275,GO:0007416,GO:0016339,GO:0016342,GO:0034332,GO:0045296,GO:0098609,GO:0098742,GO:0099055,GO:0099056,GO:0099560" cell morphogenesis|molecular_function|calcium ion binding|plasma membrane|adherens junction|cell-cell junction assembly|homophilic cell adhesion via plasma membrane adhesion molecules|multicellular organism development|synapse assembly|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|adherens junction organization|cadherin binding|cell-cell adhesion|cell-cell adhesion via plasma-membrane adhesion molecules|integral component of postsynaptic membrane|integral component of presynaptic membrane|synaptic membrane adhesion CDHR3 34.66578109 39.53572754 29.79583464 0.753643261 -0.408046313 0.572672296 1 0.156026704 0.11562079 222256 cadherin related family member 3 "GO:0000902,GO:0001618,GO:0005509,GO:0005515,GO:0005886,GO:0005912,GO:0007043,GO:0007156,GO:0007275,GO:0016021,GO:0016339,GO:0016342,GO:0034332,GO:0045296,GO:0046718,GO:0098742" cell morphogenesis|virus receptor activity|calcium ion binding|protein binding|plasma membrane|adherens junction|cell-cell junction assembly|homophilic cell adhesion via plasma membrane adhesion molecules|multicellular organism development|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|adherens junction organization|cadherin binding|viral entry into host cell|cell-cell adhesion via plasma-membrane adhesion molecules CDIN1 285.4268772 289.2350594 281.6186951 0.973667216 -0.038499328 0.915789418 1 4.062090402 3.888940606 84529 CDAN1 interacting nuclease 1 "GO:0005515,GO:0005634,GO:0005737,GO:0030218" protein binding|nucleus|cytoplasm|erythrocyte differentiation CDIP1 299.1208344 295.4775427 302.7641261 1.024660363 0.035145789 0.92229959 1 5.609780643 5.651932869 29965 cell death inducing p53 target 1 "GO:0003674,GO:0005515,GO:0005634,GO:0006915,GO:0033209,GO:0042771,GO:0046872,GO:0098560,GO:0098574" molecular_function|protein binding|nucleus|apoptotic process|tumor necrosis factor-mediated signaling pathway|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|metal ion binding|cytoplasmic side of late endosome membrane|cytoplasmic side of lysosomal membrane CDIPT 1190.771122 1145.495685 1236.046559 1.079049512 0.109761064 0.652592339 1 26.1363828 27.73052127 10423 CDP-diacylglycerol--inositol 3-phosphatidyltransferase "GO:0003881,GO:0005515,GO:0005789,GO:0005794,GO:0005886,GO:0006661,GO:0016020,GO:0016021" CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity|protein binding|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|phosphatidylinositol biosynthetic process|membrane|integral component of membrane "hsa00562,hsa00564,hsa04070" Inositol phosphate metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system CDK1 5790.723867 5368.535634 6212.9121 1.157282455 0.210741023 0.383363586 1 84.11887254 95.72028671 983 cyclin dependent kinase 1 "GO:0000086,GO:0000187,GO:0000226,GO:0000307,GO:0000781,GO:0001618,GO:0004672,GO:0004674,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005789,GO:0005813,GO:0005829,GO:0005876,GO:0006260,GO:0006281,GO:0006367,GO:0006468,GO:0006915,GO:0006977,GO:0007077,GO:0007095,GO:0007098,GO:0007344,GO:0008353,GO:0010389,GO:0010971,GO:0014038,GO:0016020,GO:0016477,GO:0016572,GO:0016579,GO:0018105,GO:0018107,GO:0030332,GO:0030496,GO:0030855,GO:0031145,GO:0034501,GO:0035173,GO:0042752,GO:0043066,GO:0045995,GO:0046718,GO:0048511,GO:0051301,GO:0070062,GO:0072686,GO:0090166,GO:0097125,GO:0097472,GO:0097711,GO:1900182,GO:1901990,GO:1905448" "G2/M transition of mitotic cell cycle|activation of MAPK activity|microtubule cytoskeleton organization|cyclin-dependent protein kinase holoenzyme complex|chromosome, telomeric region|virus receptor activity|protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial matrix|endoplasmic reticulum membrane|centrosome|cytosol|spindle microtubule|DNA replication|DNA repair|transcription initiation from RNA polymerase II promoter|protein phosphorylation|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|mitotic nuclear envelope disassembly|mitotic G2 DNA damage checkpoint|centrosome cycle|pronuclear fusion|RNA polymerase II CTD heptapeptide repeat kinase activity|regulation of G2/M transition of mitotic cell cycle|positive regulation of G2/M transition of mitotic cell cycle|regulation of Schwann cell differentiation|membrane|cell migration|histone phosphorylation|protein deubiquitination|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|cyclin binding|midbody|epithelial cell differentiation|anaphase-promoting complex-dependent catabolic process|protein localization to kinetochore|histone kinase activity|regulation of circadian rhythm|negative regulation of apoptotic process|regulation of embryonic development|viral entry into host cell|rhythmic process|cell division|extracellular exosome|mitotic spindle|Golgi disassembly|cyclin B1-CDK1 complex|cyclin-dependent protein kinase activity|ciliary basal body-plasma membrane docking|positive regulation of protein localization to nucleus|regulation of mitotic cell cycle phase transition|positive regulation of mitochondrial ATP synthesis coupled electron transport" "hsa04110,hsa04114,hsa04115,hsa04218,hsa04540,hsa04914,hsa05170,hsa05203" Cell cycle|Oocyte meiosis|p53 signaling pathway|Cellular senescence|Gap junction|Progesterone-mediated oocyte maturation|Human immunodeficiency virus 1 infection|Viral carcinogenesis CDK10 744.5349046 697.0773014 791.9925077 1.136161666 0.184168132 0.470173565 1 13.13620565 14.67510608 8558 cyclin dependent kinase 10 "GO:0004674,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0007089,GO:0007346,GO:0008285,GO:0018107,GO:0030030,GO:0032956,GO:0036064,GO:0043410,GO:1902018" protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|traversing start control point of mitotic cell cycle|regulation of mitotic cell cycle|negative regulation of cell population proliferation|peptidyl-threonine phosphorylation|cell projection organization|regulation of actin cytoskeleton organization|ciliary basal body|positive regulation of MAPK cascade|negative regulation of cilium assembly CDK11A 404.9020954 359.9832034 449.8209874 1.249561044 0.321421382 0.265710497 1 6.355157772 7.808273062 728642 cyclin dependent kinase 11A "GO:0000278,GO:0001558,GO:0004672,GO:0004674,GO:0004693,GO:0005524,GO:0005634,GO:0005737,GO:0006355,GO:0006468,GO:0006915,GO:0007346,GO:0050684" "mitotic cell cycle|regulation of cell growth|protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|protein phosphorylation|apoptotic process|regulation of mitotic cell cycle|regulation of mRNA processing" CDK11B 1056.120584 1067.464644 1044.776524 0.978745788 -0.0309939 0.903085677 1 14.02477255 13.49698955 984 cyclin dependent kinase 11B "GO:0000278,GO:0001558,GO:0003723,GO:0004672,GO:0004674,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006355,GO:0006468,GO:0006915,GO:0007346,GO:0050684" "mitotic cell cycle|regulation of cell growth|RNA binding|protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|protein phosphorylation|apoptotic process|regulation of mitotic cell cycle|regulation of mRNA processing" CDK12 2084.614865 2217.121984 1952.107747 0.880469257 -0.183655463 0.437833801 1 9.790957831 8.476382678 51755 cyclin dependent kinase 12 "GO:0000307,GO:0002944,GO:0004672,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006368,GO:0006397,GO:0006468,GO:0008024,GO:0008353,GO:0008380,GO:0016607,GO:0019901,GO:0019908,GO:0030332,GO:0032968,GO:0043405,GO:0043484,GO:0046777,GO:0051726,GO:0070816,GO:2000737" cyclin-dependent protein kinase holoenzyme complex|cyclin K-CDK12 complex|protein kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|transcription elongation from RNA polymerase II promoter|mRNA processing|protein phosphorylation|cyclin/CDK positive transcription elongation factor complex|RNA polymerase II CTD heptapeptide repeat kinase activity|RNA splicing|nuclear speck|protein kinase binding|nuclear cyclin-dependent protein kinase holoenzyme complex|cyclin binding|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of MAP kinase activity|regulation of RNA splicing|protein autophosphorylation|regulation of cell cycle|phosphorylation of RNA polymerase II C-terminal domain|negative regulation of stem cell differentiation other CDK13 1042.515945 1038.333055 1046.698836 1.008056934 0.011577123 0.966639966 1 6.314257835 6.258619542 8621 cyclin dependent kinase 13 "GO:0000307,GO:0000380,GO:0002945,GO:0003723,GO:0004672,GO:0004693,GO:0005515,GO:0005524,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006368,GO:0006468,GO:0007088,GO:0007275,GO:0008024,GO:0008284,GO:0008353,GO:0016032,GO:0016607,GO:0019901,GO:0019908,GO:0030097,GO:0030332,GO:0032968,GO:0043312,GO:0070816,GO:1904813,GO:2000737" "cyclin-dependent protein kinase holoenzyme complex|alternative mRNA splicing, via spliceosome|cyclin K-CDK13 complex|RNA binding|protein kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|extracellular region|extracellular space|nucleus|nucleoplasm|Golgi apparatus|cytosol|transcription elongation from RNA polymerase II promoter|protein phosphorylation|regulation of mitotic nuclear division|multicellular organism development|cyclin/CDK positive transcription elongation factor complex|positive regulation of cell population proliferation|RNA polymerase II CTD heptapeptide repeat kinase activity|viral process|nuclear speck|protein kinase binding|nuclear cyclin-dependent protein kinase holoenzyme complex|hemopoiesis|cyclin binding|positive regulation of transcription elongation from RNA polymerase II promoter|neutrophil degranulation|phosphorylation of RNA polymerase II C-terminal domain|ficolin-1-rich granule lumen|negative regulation of stem cell differentiation" CDK14 804.4140374 679.3902654 929.4378094 1.368046993 0.452117788 0.072227563 1 6.561311943 8.825978804 5218 cyclin dependent kinase 14 "GO:0000083,GO:0000086,GO:0000308,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0016055,GO:0030332,GO:0051301,GO:0051726,GO:0060828" regulation of transcription involved in G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|cytoplasmic cyclin-dependent protein kinase holoenzyme complex|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|protein phosphorylation|Wnt signaling pathway|cyclin binding|cell division|regulation of cell cycle|regulation of canonical Wnt signaling pathway hsa05202 Transcriptional misregulation in cancer CDK15 41.6417074 20.80827765 62.47513714 3.002417508 1.586124608 0.015375183 0.722527912 0.109950449 0.324593089 65061 cyclin dependent kinase 15 "GO:0000083,GO:0004674,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0030332,GO:0046872,GO:0051726" regulation of transcription involved in G1/S transition of mitotic cell cycle|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|protein phosphorylation|cyclin binding|metal ion binding|regulation of cell cycle CDK16 4321.471611 3989.98724 4652.955983 1.166158111 0.221763407 0.352997274 1 37.22046595 42.67862524 5127 cyclin dependent kinase 16 "GO:0000083,GO:0004674,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0006887,GO:0007283,GO:0008021,GO:0015630,GO:0030252,GO:0031175,GO:0031234,GO:0043005,GO:0051726,GO:0061178" regulation of transcription involved in G1/S transition of mitotic cell cycle|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|protein phosphorylation|exocytosis|spermatogenesis|synaptic vesicle|microtubule cytoskeleton|growth hormone secretion|neuron projection development|extrinsic component of cytoplasmic side of plasma membrane|neuron projection|regulation of cell cycle|regulation of insulin secretion involved in cellular response to glucose stimulus CDK17 1795.592428 1707.319181 1883.865674 1.103405675 0.141963306 0.550296777 1 19.59073034 21.25479979 5128 cyclin dependent kinase 17 "GO:0000083,GO:0004672,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0051726" regulation of transcription involved in G1/S transition of mitotic cell cycle|protein kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|regulation of cell cycle CDK18 19.09417139 21.84869154 16.33965125 0.74785491 -0.419169691 0.666417165 1 0.34610404 0.254504343 5129 cyclin dependent kinase 18 "GO:0000083,GO:0004693,GO:0005515,GO:0005524,GO:0005575,GO:0005634,GO:0005737,GO:0006468,GO:0051726" regulation of transcription involved in G1/S transition of mitotic cell cycle|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|cellular_component|nucleus|cytoplasm|protein phosphorylation|regulation of cell cycle CDK19 550.144242 589.9146715 510.3738126 0.865165485 -0.208951984 0.436773317 1 3.577981793 3.043746576 23097 cyclin dependent kinase 19 "GO:0004693,GO:0005524,GO:0005634,GO:0005829,GO:0006468,GO:0008353,GO:0016592,GO:0043065,GO:0050729,GO:0051726,GO:0071222" cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|cytosol|protein phosphorylation|RNA polymerase II CTD heptapeptide repeat kinase activity|mediator complex|positive regulation of apoptotic process|positive regulation of inflammatory response|regulation of cell cycle|cellular response to lipopolysaccharide CDK2 2547.812778 2215.041156 2880.5844 1.300465408 0.379028024 0.109001549 1 49.58585379 63.40562364 1017 cyclin dependent kinase 2 "GO:0000082,GO:0000086,GO:0000307,GO:0004674,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005813,GO:0005829,GO:0006260,GO:0006281,GO:0006468,GO:0006977,GO:0007099,GO:0007165,GO:0007265,GO:0008284,GO:0010389,GO:0010468,GO:0015030,GO:0016572,GO:0018105,GO:0019904,GO:0030332,GO:0031145,GO:0031571,GO:0035173,GO:0046872,GO:0051298,GO:0051301,GO:0051321,GO:0060968,GO:0071732,GO:0097123,GO:0097124,GO:0097134,GO:0097135,GO:0097472,GO:1901796" "G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|endosome|centrosome|cytosol|DNA replication|DNA repair|protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|centriole replication|signal transduction|Ras protein signal transduction|positive regulation of cell population proliferation|regulation of G2/M transition of mitotic cell cycle|regulation of gene expression|Cajal body|histone phosphorylation|peptidyl-serine phosphorylation|protein domain specific binding|cyclin binding|anaphase-promoting complex-dependent catabolic process|mitotic G1 DNA damage checkpoint|histone kinase activity|metal ion binding|centrosome duplication|cell division|meiotic cell cycle|regulation of gene silencing|cellular response to nitric oxide|cyclin A1-CDK2 complex|cyclin A2-CDK2 complex|cyclin E1-CDK2 complex|cyclin E2-CDK2 complex|cyclin-dependent protein kinase activity|regulation of signal transduction by p53 class mediator" "hsa04068,hsa04110,hsa04114,hsa04115,hsa04151,hsa04218,hsa04914,hsa04934,hsa05160,hsa05161,hsa05162,hsa05165,hsa05166,hsa05169,hsa05200,hsa05203,hsa05215,hsa05222,hsa05226" FoxO signaling pathway|Cell cycle|Oocyte meiosis|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Progesterone-mediated oocyte maturation|Cushing syndrome|Hepatitis C|Hepatitis B|Measles|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Prostate cancer|Small cell lung cancer|Gastric cancer other CDK20 28.77995846 36.41448589 21.14543103 0.580687342 -0.784166508 0.293285448 1 0.810752685 0.462915725 23552 cyclin dependent kinase 20 "GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005929,GO:0006468,GO:0007049,GO:0007275,GO:0051301,GO:0051726" cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cilium|protein phosphorylation|cell cycle|multicellular organism development|cell division|regulation of cell cycle CDK2AP1 1678.426365 1571.024963 1785.827766 1.136727811 0.184886842 0.437033761 1 52.33627643 58.49658118 8099 cyclin dependent kinase 2 associated protein 1 "GO:0001934,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006261,GO:0007049,GO:0048471,GO:0070182" positive regulation of protein phosphorylation|protein binding|nucleus|nucleoplasm|cytosol|DNA-dependent DNA replication|cell cycle|perinuclear region of cytoplasm|DNA polymerase binding CDK2AP2 832.6486368 777.1891703 888.1081033 1.142718063 0.192469499 0.443619814 1 39.50205486 44.38435968 10263 cyclin dependent kinase 2 associated protein 2 "GO:0005515,GO:0005634,GO:0005737,GO:0005874,GO:0070507,GO:2000035,GO:2000134" protein binding|nucleus|cytoplasm|microtubule|regulation of microtubule cytoskeleton organization|regulation of stem cell division|negative regulation of G1/S transition of mitotic cell cycle CDK3 55.64263543 60.34400519 50.94126567 0.84418105 -0.24437565 0.692715396 1 2.052548534 1.703727811 1018 cyclin dependent kinase 3 "GO:0000082,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0006468,GO:0006974,GO:0008283,GO:0045023,GO:0051301,GO:0051726" G1/S transition of mitotic cell cycle|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|protein phosphorylation|cellular response to DNA damage stimulus|cell population proliferation|G0 to G1 transition|cell division|regulation of cell cycle CDK4 4351.73612 4317.717613 4385.754627 1.015757634 0.022556207 0.925712776 1 123.5542377 123.4010682 1019 cyclin dependent kinase 4 "GO:0000079,GO:0000082,GO:0000307,GO:0000785,GO:0002088,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005829,GO:0005923,GO:0006367,GO:0006468,GO:0007165,GO:0007623,GO:0008284,GO:0008353,GO:0009636,GO:0010288,GO:0010468,GO:0010971,GO:0016538,GO:0016592,GO:0030332,GO:0031100,GO:0031965,GO:0032869,GO:0033574,GO:0040014,GO:0042493,GO:0043065,GO:0044877,GO:0045727,GO:0045787,GO:0045793,GO:0046626,GO:0046890,GO:0048146,GO:0048471,GO:0050994,GO:0051301,GO:0051726,GO:0055093,GO:0060612,GO:0071157,GO:0071222,GO:0071353,GO:0097129,GO:1904628,GO:1904637,GO:2000134" regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|chromatin|lens development in camera-type eye|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytosol|bicellular tight junction|transcription initiation from RNA polymerase II promoter|protein phosphorylation|signal transduction|circadian rhythm|positive regulation of cell population proliferation|RNA polymerase II CTD heptapeptide repeat kinase activity|response to toxic substance|response to lead ion|regulation of gene expression|positive regulation of G2/M transition of mitotic cell cycle|cyclin-dependent protein serine/threonine kinase regulator activity|mediator complex|cyclin binding|animal organ regeneration|nuclear membrane|cellular response to insulin stimulus|response to testosterone|regulation of multicellular organism growth|response to drug|positive regulation of apoptotic process|protein-containing complex binding|positive regulation of translation|positive regulation of cell cycle|positive regulation of cell size|regulation of insulin receptor signaling pathway|regulation of lipid biosynthetic process|positive regulation of fibroblast proliferation|perinuclear region of cytoplasm|regulation of lipid catabolic process|cell division|regulation of cell cycle|response to hyperoxia|adipose tissue development|negative regulation of cell cycle arrest|cellular response to lipopolysaccharide|cellular response to interleukin-4|cyclin D2-CDK4 complex|cellular response to phorbol 13-acetate 12-myristate|cellular response to ionomycin|negative regulation of G1/S transition of mitotic cell cycle "hsa01522,hsa04110,hsa04115,hsa04151,hsa04218,hsa04530,hsa04660,hsa04933,hsa04934,hsa05160,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05169,hsa05200,hsa05203,hsa05212,hsa05214,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225" Endocrine resistance|Cell cycle|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Tight junction|T cell receptor signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Hepatitis C|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Pancreatic cancer|Glioma|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma CDK5 551.1462557 389.1147921 713.1777193 1.832820889 0.874065807 0.001145964 0.211771027 18.50832557 33.35479955 1020 cyclin dependent kinase 5 "GO:0000083,GO:0000226,GO:0001764,GO:0001963,GO:0002039,GO:0004672,GO:0004674,GO:0004693,GO:0005176,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005874,GO:0005886,GO:0006468,GO:0006886,GO:0006913,GO:0007005,GO:0007160,GO:0007268,GO:0007409,GO:0007416,GO:0007519,GO:0008017,GO:0008045,GO:0008542,GO:0009611,GO:0014044,GO:0014069,GO:0016020,GO:0016079,GO:0016241,GO:0016301,GO:0016310,GO:0016533,GO:0016572,GO:0018105,GO:0018107,GO:0019233,GO:0019901,GO:0021697,GO:0021766,GO:0021819,GO:0021954,GO:0022038,GO:0030027,GO:0030054,GO:0030175,GO:0030182,GO:0030334,GO:0030424,GO:0030425,GO:0030426,GO:0030517,GO:0030549,GO:0030866,GO:0031175,GO:0031397,GO:0031594,GO:0031914,GO:0032092,GO:0032801,GO:0034352,GO:0035249,GO:0035418,GO:0042501,GO:0042981,GO:0043005,GO:0043025,GO:0043113,GO:0043125,GO:0043204,GO:0043525,GO:0045786,GO:0045860,GO:0045861,GO:0045892,GO:0045956,GO:0046777,GO:0046826,GO:0046875,GO:0048148,GO:0048156,GO:0048167,GO:0048488,GO:0048489,GO:0048511,GO:0048675,GO:0048709,GO:0048813,GO:0050321,GO:0051301,GO:0051402,GO:0051879,GO:0051966,GO:0060079,GO:0061001,GO:0070509,GO:0071156,GO:0090314,GO:0098685,GO:0098793,GO:0098883,GO:0098978,GO:0099601,GO:0099635,GO:0099703,GO:0106310,GO:0106311,GO:1901215,GO:1901387,GO:1901796,GO:1903076,GO:1903421,GO:1904646,GO:2000251" "regulation of transcription involved in G1/S transition of mitotic cell cycle|microtubule cytoskeleton organization|neuron migration|synaptic transmission, dopaminergic|p53 binding|protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|ErbB-2 class receptor binding|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|microtubule|plasma membrane|protein phosphorylation|intracellular protein transport|nucleocytoplasmic transport|mitochondrion organization|cell-matrix adhesion|chemical synaptic transmission|axonogenesis|synapse assembly|skeletal muscle tissue development|microtubule binding|motor neuron axon guidance|visual learning|response to wounding|Schwann cell development|postsynaptic density|membrane|synaptic vesicle exocytosis|regulation of macroautophagy|kinase activity|phosphorylation|protein kinase 5 complex|histone phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|sensory perception of pain|protein kinase binding|cerebellar cortex formation|hippocampus development|layer formation in cerebral cortex|central nervous system neuron development|corpus callosum development|lamellipodium|cell junction|filopodium|neuron differentiation|regulation of cell migration|axon|dendrite|growth cone|negative regulation of axon extension|acetylcholine receptor activator activity|cortical actin cytoskeleton organization|neuron projection development|negative regulation of protein ubiquitination|neuromuscular junction|negative regulation of synaptic plasticity|positive regulation of protein binding|receptor catabolic process|positive regulation of glial cell apoptotic process|synaptic transmission, glutamatergic|protein localization to synapse|serine phosphorylation of STAT protein|regulation of apoptotic process|neuron projection|neuronal cell body|receptor clustering|ErbB-3 class receptor binding|perikaryon|positive regulation of neuron apoptotic process|negative regulation of cell cycle|positive regulation of protein kinase activity|negative regulation of proteolysis|negative regulation of transcription, DNA-templated|positive regulation of calcium ion-dependent exocytosis|protein autophosphorylation|negative regulation of protein export from nucleus|ephrin receptor binding|behavioral response to cocaine|tau protein binding|regulation of synaptic plasticity|synaptic vesicle endocytosis|synaptic vesicle transport|rhythmic process|axon extension|oligodendrocyte differentiation|dendrite morphogenesis|tau-protein kinase activity|cell division|neuron apoptotic process|Hsp90 protein binding|regulation of synaptic transmission, glutamatergic|excitatory postsynaptic potential|regulation of dendritic spine morphogenesis|calcium ion import|regulation of cell cycle arrest|positive regulation of protein targeting to membrane|Schaffer collateral - CA1 synapse|presynapse|synapse pruning|glutamatergic synapse|regulation of neurotransmitter receptor activity|voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels|induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration|protein serine kinase activity|protein threonine kinase activity|negative regulation of neuron death|positive regulation of voltage-gated calcium channel activity|regulation of signal transduction by p53 class mediator|regulation of protein localization to plasma membrane|regulation of synaptic vesicle recycling|cellular response to amyloid-beta|positive regulation of actin cytoskeleton reorganization" "hsa04360,hsa05010,hsa05022,hsa05030" Axon guidance|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Cocaine addiction CDK5R1 170.9014778 159.183324 182.6196316 1.147228409 0.198152656 0.616629846 1 1.645742239 1.856448421 8851 cyclin dependent kinase 5 regulatory subunit 1 "GO:0000079,GO:0000226,GO:0001764,GO:0002020,GO:0004672,GO:0005509,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0007158,GO:0007213,GO:0007411,GO:0007413,GO:0007420,GO:0009792,GO:0014069,GO:0016020,GO:0016241,GO:0016301,GO:0016533,GO:0018105,GO:0018107,GO:0019901,GO:0021549,GO:0021722,GO:0021766,GO:0021819,GO:0030182,GO:0030295,GO:0030424,GO:0030425,GO:0030426,GO:0030517,GO:0031116,GO:0031175,GO:0031594,GO:0032147,GO:0032956,GO:0035235,GO:0035255,GO:0042501,GO:0043005,GO:0043014,GO:0043025,GO:0043197,GO:0043204,GO:0043231,GO:0043292,GO:0043525,GO:0043539,GO:0045296,GO:0045664,GO:0045737,GO:0045892,GO:0046875,GO:0048013,GO:0048471,GO:0048487,GO:0048511,GO:0051015,GO:0061001,GO:0061575,GO:0071158,GO:0090314,GO:0098693,GO:0098793,GO:1901796" "regulation of cyclin-dependent protein serine/threonine kinase activity|microtubule cytoskeleton organization|neuron migration|protease binding|protein kinase activity|calcium ion binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|neuron cell-cell adhesion|G protein-coupled acetylcholine receptor signaling pathway|axon guidance|axonal fasciculation|brain development|embryo development ending in birth or egg hatching|postsynaptic density|membrane|regulation of macroautophagy|kinase activity|protein kinase 5 complex|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein kinase binding|cerebellum development|superior olivary nucleus maturation|hippocampus development|layer formation in cerebral cortex|neuron differentiation|protein kinase activator activity|axon|dendrite|growth cone|negative regulation of axon extension|positive regulation of microtubule polymerization|neuron projection development|neuromuscular junction|activation of protein kinase activity|regulation of actin cytoskeleton organization|ionotropic glutamate receptor signaling pathway|ionotropic glutamate receptor binding|serine phosphorylation of STAT protein|neuron projection|alpha-tubulin binding|neuronal cell body|dendritic spine|perikaryon|intracellular membrane-bounded organelle|contractile fiber|positive regulation of neuron apoptotic process|protein serine/threonine kinase activator activity|cadherin binding|regulation of neuron differentiation|positive regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|ephrin receptor binding|ephrin receptor signaling pathway|perinuclear region of cytoplasm|beta-tubulin binding|rhythmic process|actin filament binding|regulation of dendritic spine morphogenesis|cyclin-dependent protein serine/threonine kinase activator activity|positive regulation of cell cycle arrest|positive regulation of protein targeting to membrane|regulation of synaptic vesicle cycle|presynapse|regulation of signal transduction by p53 class mediator" "hsa05010,hsa05022,hsa05030" Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Cocaine addiction CDK5R2 20.4566474 19.76786377 21.14543103 1.069687209 0.097188995 0.973111657 1 0.423684561 0.445626101 8941 cyclin dependent kinase 5 regulatory subunit 2 "GO:0000079,GO:0001764,GO:0003779,GO:0005737,GO:0005886,GO:0008289,GO:0016020,GO:0016533,GO:0021549,GO:0021722,GO:0021766,GO:0021819,GO:0030426,GO:0043005,GO:0045737,GO:0045956,GO:0061575" regulation of cyclin-dependent protein serine/threonine kinase activity|neuron migration|actin binding|cytoplasm|plasma membrane|lipid binding|membrane|protein kinase 5 complex|cerebellum development|superior olivary nucleus maturation|hippocampus development|layer formation in cerebral cortex|growth cone|neuron projection|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of calcium ion-dependent exocytosis|cyclin-dependent protein serine/threonine kinase activator activity CDK5RAP1 772.4279346 748.0575816 796.7982875 1.065156356 0.091065221 0.722383009 1 18.9026791 19.79738839 51654 CDK5 regulatory subunit associated protein 1 "GO:0005575,GO:0005739,GO:0005829,GO:0007420,GO:0019901,GO:0035597,GO:0035600,GO:0044877,GO:0045664,GO:0045736,GO:0045903,GO:0046872,GO:0051539,GO:0070131,GO:0070900" "cellular_component|mitochondrion|cytosol|brain development|protein kinase binding|N6-isopentenyladenosine methylthiotransferase activity|tRNA methylthiolation|protein-containing complex binding|regulation of neuron differentiation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of translational fidelity|metal ion binding|4 iron, 4 sulfur cluster binding|positive regulation of mitochondrial translation|mitochondrial tRNA modification" CDK5RAP2 2230.739524 2344.052478 2117.426571 0.903318757 -0.146692928 0.535533946 1 20.09602772 17.84935093 55755 CDK5 regulatory subunit associated protein 2 "GO:0000086,GO:0000132,GO:0000226,GO:0000242,GO:0000922,GO:0000976,GO:0001578,GO:0005515,GO:0005516,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0005856,GO:0005874,GO:0007059,GO:0007098,GO:0007099,GO:0007420,GO:0008017,GO:0008274,GO:0010389,GO:0015631,GO:0019901,GO:0022008,GO:0030054,GO:0031023,GO:0031116,GO:0035371,GO:0043015,GO:0045664,GO:0045665,GO:0045893,GO:0046600,GO:0048471,GO:0070062,GO:0090266,GO:0097431,GO:0097711" "G2/M transition of mitotic cell cycle|establishment of mitotic spindle orientation|microtubule cytoskeleton organization|pericentriolar material|spindle pole|transcription regulatory region sequence-specific DNA binding|microtubule bundle formation|protein binding|calmodulin binding|cytoplasm|Golgi apparatus|centrosome|cytosol|cytoskeleton|microtubule|chromosome segregation|centrosome cycle|centriole replication|brain development|microtubule binding|gamma-tubulin ring complex|regulation of G2/M transition of mitotic cell cycle|tubulin binding|protein kinase binding|neurogenesis|cell junction|microtubule organizing center organization|positive regulation of microtubule polymerization|microtubule plus-end|gamma-tubulin binding|regulation of neuron differentiation|negative regulation of neuron differentiation|positive regulation of transcription, DNA-templated|negative regulation of centriole replication|perinuclear region of cytoplasm|extracellular exosome|regulation of mitotic cell cycle spindle assembly checkpoint|mitotic spindle pole|ciliary basal body-plasma membrane docking" CDK5RAP3 1353.15053 1383.750464 1322.550595 0.955772468 -0.065260886 0.788192145 1 24.17290312 22.71718454 80279 CDK5 regulatory subunit associated protein 3 "GO:0000079,GO:0001889,GO:0001933,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0005874,GO:0007095,GO:0007346,GO:0007420,GO:0008283,GO:0010921,GO:0016020,GO:0016032,GO:0019901,GO:0030262,GO:0030332,GO:0030968,GO:0031398,GO:0032088,GO:0032991,GO:0034976,GO:0043231,GO:0043407,GO:0044387,GO:0044389,GO:0044818,GO:0045664,GO:0045944,GO:0051019,GO:0051059,GO:0060318,GO:0071569,GO:0071901,GO:0097371,GO:1900182,GO:1901798,GO:1903363,GO:2000060" regulation of cyclin-dependent protein serine/threonine kinase activity|liver development|negative regulation of protein phosphorylation|protein binding|nucleus|nucleolus|cytoplasm|centrosome|cytosol|microtubule|mitotic G2 DNA damage checkpoint|regulation of mitotic cell cycle|brain development|cell population proliferation|regulation of phosphatase activity|membrane|viral process|protein kinase binding|apoptotic nuclear changes|cyclin binding|endoplasmic reticulum unfolded protein response|positive regulation of protein ubiquitination|negative regulation of NF-kappaB transcription factor activity|protein-containing complex|response to endoplasmic reticulum stress|intracellular membrane-bounded organelle|negative regulation of MAP kinase activity|negative regulation of protein kinase activity by regulation of protein phosphorylation|ubiquitin-like protein ligase binding|mitotic G2/M transition checkpoint|regulation of neuron differentiation|positive regulation of transcription by RNA polymerase II|mitogen-activated protein kinase binding|NF-kappaB binding|definitive erythrocyte differentiation|protein ufmylation|negative regulation of protein serine/threonine kinase activity|MDM2/MDM4 family protein binding|positive regulation of protein localization to nucleus|positive regulation of signal transduction by p53 class mediator|negative regulation of cellular protein catabolic process|positive regulation of ubiquitin-dependent protein catabolic process CDK6 1645.765341 1823.845536 1467.685145 0.80472009 -0.313441044 0.187321229 1 8.097777386 6.407400283 1021 cyclin dependent kinase 6 "GO:0000082,GO:0000307,GO:0001726,GO:0001954,GO:0003323,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006468,GO:0007050,GO:0008285,GO:0008353,GO:0009615,GO:0010468,GO:0014002,GO:0016592,GO:0021542,GO:0021670,GO:0030332,GO:0042063,GO:0043697,GO:0045596,GO:0045638,GO:0045646,GO:0045656,GO:0045668,GO:0045786,GO:0048146,GO:0048699,GO:0050680,GO:0051301,GO:0051726,GO:0098770,GO:2000134,GO:2000145,GO:2000773" G1/S transition of mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|ruffle|positive regulation of cell-matrix adhesion|type B pancreatic cell development|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|protein phosphorylation|cell cycle arrest|negative regulation of cell population proliferation|RNA polymerase II CTD heptapeptide repeat kinase activity|response to virus|regulation of gene expression|astrocyte development|mediator complex|dentate gyrus development|lateral ventricle development|cyclin binding|gliogenesis|cell dedifferentiation|negative regulation of cell differentiation|negative regulation of myeloid cell differentiation|regulation of erythrocyte differentiation|negative regulation of monocyte differentiation|negative regulation of osteoblast differentiation|negative regulation of cell cycle|positive regulation of fibroblast proliferation|generation of neurons|negative regulation of epithelial cell proliferation|cell division|regulation of cell cycle|FBXO family protein binding|negative regulation of G1/S transition of mitotic cell cycle|regulation of cell motility|negative regulation of cellular senescence "hsa04110,hsa04115,hsa04151,hsa04218,hsa04934,hsa05160,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05169,hsa05200,hsa05203,hsa05206,hsa05212,hsa05214,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225" Cell cycle|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Cushing syndrome|Hepatitis C|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|MicroRNAs in cancer|Pancreatic cancer|Glioma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma CDK7 1421.402663 1358.780531 1484.024796 1.092174021 0.127202746 0.596507105 1 45.26568015 48.61072193 1022 cyclin dependent kinase 7 "GO:0000079,GO:0000082,GO:0000086,GO:0000439,GO:0001650,GO:0004672,GO:0004674,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005675,GO:0005737,GO:0005829,GO:0005886,GO:0006283,GO:0006294,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006468,GO:0007050,GO:0008022,GO:0008094,GO:0008353,GO:0016301,GO:0019907,GO:0042795,GO:0045944,GO:0048471,GO:0050821,GO:0051301,GO:0070516,GO:0070816,GO:0070985" "regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|transcription factor TFIIH core complex|fibrillar center|protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|transcription factor TFIIH holo complex|cytoplasm|cytosol|plasma membrane|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|protein phosphorylation|cell cycle arrest|protein C-terminus binding|DNA-dependent ATPase activity|RNA polymerase II CTD heptapeptide repeat kinase activity|kinase activity|cyclin-dependent protein kinase activating kinase holoenzyme complex|snRNA transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|protein stabilization|cell division|CAK-ERCC2 complex|phosphorylation of RNA polymerase II C-terminal domain|transcription factor TFIIK complex" "hsa03022,hsa03420,hsa04110" Basal transcription factors|Nucleotide excision repair|Cell cycle other CDK8 616.9200433 551.4193578 682.4207288 1.237571223 0.307511555 0.240273652 1 7.062212061 8.593738511 1024 cyclin dependent kinase 8 "GO:0004672,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006367,GO:0006468,GO:0008353,GO:0016592,GO:0032991,GO:0045944,GO:0051726" protein kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|transcription initiation from RNA polymerase II promoter|protein phosphorylation|RNA polymerase II CTD heptapeptide repeat kinase activity|mediator complex|protein-containing complex|positive regulation of transcription by RNA polymerase II|regulation of cell cycle other CDK9 1620.623029 1605.358621 1635.887437 1.01901682 0.027177865 0.911671226 1 34.50464723 34.57244726 1025 cyclin dependent kinase 9 "GO:0000978,GO:0001223,GO:0003677,GO:0003682,GO:0004672,GO:0004674,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006281,GO:0006282,GO:0006366,GO:0006367,GO:0006368,GO:0006468,GO:0007346,GO:0008023,GO:0008024,GO:0008283,GO:0008353,GO:0010613,GO:0016020,GO:0016301,GO:0016592,GO:0016605,GO:0019901,GO:0031056,GO:0031297,GO:0033129,GO:0036464,GO:0042493,GO:0042795,GO:0045944,GO:0050434,GO:0051147,GO:0070691,GO:0070816,GO:0071157,GO:0071345,GO:0097322,GO:1900364,GO:1903839,GO:2001168" RNA polymerase II cis-regulatory region sequence-specific DNA binding|transcription coactivator binding|DNA binding|chromatin binding|protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|DNA repair|regulation of DNA repair|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|protein phosphorylation|regulation of mitotic cell cycle|transcription elongation factor complex|cyclin/CDK positive transcription elongation factor complex|cell population proliferation|RNA polymerase II CTD heptapeptide repeat kinase activity|positive regulation of cardiac muscle hypertrophy|membrane|kinase activity|mediator complex|PML body|protein kinase binding|regulation of histone modification|replication fork processing|positive regulation of histone phosphorylation|cytoplasmic ribonucleoprotein granule|response to drug|snRNA transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|positive regulation of viral transcription|regulation of muscle cell differentiation|P-TEFb complex|phosphorylation of RNA polymerase II C-terminal domain|negative regulation of cell cycle arrest|cellular response to cytokine stimulus|7SK snRNA binding|negative regulation of mRNA polyadenylation|positive regulation of mRNA 3'-UTR binding|positive regulation of histone H2B ubiquitination hsa05202 Transcriptional misregulation in cancer other CDKAL1 182.1132872 163.3449796 200.8815948 1.229799626 0.298423273 0.432861752 1 1.488376531 1.799775555 54901 CDK5 regulatory subunit associated protein 1 like 1 "GO:0005515,GO:0005783,GO:0005789,GO:0005791,GO:0006400,GO:0008150,GO:0016020,GO:0016021,GO:0035598,GO:0035600,GO:0046872,GO:0051539,GO:0061712,GO:1990145" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|rough endoplasmic reticulum|tRNA modification|biological_process|membrane|integral component of membrane|N6-threonylcarbomyladenosine methylthiotransferase activity|tRNA methylthiolation|metal ion binding|4 iron, 4 sulfur cluster binding|tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase|maintenance of translational fidelity" CDKL1 145.2672987 167.5066351 123.0279624 0.734466204 -0.445231988 0.279592196 1 0.871468244 0.629353369 8814 cyclin dependent kinase like 1 "GO:0004693,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006468,GO:0007507,GO:0035869,GO:0043231,GO:0051726,GO:0070062,GO:1902017" cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|protein phosphorylation|heart development|ciliary transition zone|intracellular membrane-bounded organelle|regulation of cell cycle|extracellular exosome|regulation of cilium assembly CDKL3 45.92224982 32.25283036 59.59166927 1.847641543 0.88568489 0.154190447 1 0.371524774 0.674957886 51265 cyclin dependent kinase like 3 "GO:0004672,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006464,GO:0006468,GO:0030517,GO:0050775,GO:0051726,GO:0097484" protein kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cellular protein modification process|protein phosphorylation|negative regulation of axon extension|positive regulation of dendrite morphogenesis|regulation of cell cycle|dendrite extension CDKL5 176.569034 207.0423626 146.0957053 0.705631946 -0.503012217 0.187228285 1 3.143519308 2.181049616 6792 cyclin dependent kinase like 5 "GO:0001764,GO:0004672,GO:0004674,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005813,GO:0006468,GO:0016301,GO:0031267,GO:0032587,GO:0032839,GO:0036064,GO:0043547,GO:0044294,GO:0045773,GO:0046777,GO:0048471,GO:0050773,GO:0050775,GO:0051726,GO:0060999,GO:0097542,GO:0098978,GO:0099092,GO:0099175,GO:1902017" "neuron migration|protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|centrosome|protein phosphorylation|kinase activity|small GTPase binding|ruffle membrane|dendrite cytoplasm|ciliary basal body|positive regulation of GTPase activity|dendritic growth cone|positive regulation of axon extension|protein autophosphorylation|perinuclear region of cytoplasm|regulation of dendrite development|positive regulation of dendrite morphogenesis|regulation of cell cycle|positive regulation of dendritic spine development|ciliary tip|glutamatergic synapse|postsynaptic density, intracellular component|regulation of postsynapse organization|regulation of cilium assembly" CDKN1A 1426.422294 1225.607554 1627.237033 1.327698274 0.408927324 0.087518754 1 24.08262981 31.43941664 1026 cyclin dependent kinase inhibitor 1A "GO:0000079,GO:0000082,GO:0000086,GO:0000307,GO:0004860,GO:0004861,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0006367,GO:0006606,GO:0006974,GO:0006977,GO:0006978,GO:0007050,GO:0007095,GO:0007265,GO:0007507,GO:0008285,GO:0009636,GO:0010165,GO:0010243,GO:0010629,GO:0016604,GO:0019221,GO:0019901,GO:0019912,GO:0030308,GO:0030332,GO:0030890,GO:0031100,GO:0031625,GO:0031668,GO:0032091,GO:0032991,GO:0034198,GO:0034605,GO:0042060,GO:0042246,GO:0042326,GO:0042493,GO:0042771,GO:0043066,GO:0043068,GO:0044877,GO:0045736,GO:0045860,GO:0046685,GO:0046872,GO:0048146,GO:0048471,GO:0050821,GO:0051412,GO:0055093,GO:0060574,GO:0070557,GO:0071479,GO:0071480,GO:0071493,GO:0071850,GO:0090398,GO:0090399,GO:0090400,GO:0097193,GO:0140311,GO:1902806,GO:1904030,GO:1904031,GO:1904706,GO:1905179,GO:2000134,GO:2000279,GO:2000379" "regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|protein kinase inhibitor activity|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|protein import into nucleus|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|cell cycle arrest|mitotic G2 DNA damage checkpoint|Ras protein signal transduction|heart development|negative regulation of cell population proliferation|response to toxic substance|response to X-ray|response to organonitrogen compound|negative regulation of gene expression|nuclear body|cytokine-mediated signaling pathway|protein kinase binding|cyclin-dependent protein kinase activating kinase activity|negative regulation of cell growth|cyclin binding|positive regulation of B cell proliferation|animal organ regeneration|ubiquitin protein ligase binding|cellular response to extracellular stimulus|negative regulation of protein binding|protein-containing complex|cellular response to amino acid starvation|cellular response to heat|wound healing|tissue regeneration|negative regulation of phosphorylation|response to drug|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of apoptotic process|positive regulation of programmed cell death|protein-containing complex binding|negative regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of protein kinase activity|response to arsenic-containing substance|metal ion binding|positive regulation of fibroblast proliferation|perinuclear region of cytoplasm|protein stabilization|response to corticosterone|response to hyperoxia|intestinal epithelial cell maturation|PCNA-p21 complex|cellular response to ionizing radiation|cellular response to gamma radiation|cellular response to UV-B|mitotic cell cycle arrest|cellular senescence|replicative senescence|stress-induced premature senescence|intrinsic apoptotic signaling pathway|protein sequestering activity|regulation of cell cycle G1/S phase transition|negative regulation of cyclin-dependent protein kinase activity|positive regulation of cyclin-dependent protein kinase activity|negative regulation of vascular associated smooth muscle cell proliferation|negative regulation of cardiac muscle tissue regeneration|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of DNA biosynthetic process|positive regulation of reactive oxygen species metabolic process" "hsa01522,hsa01524,hsa04012,hsa04066,hsa04068,hsa04110,hsa04115,hsa04151,hsa04218,hsa04630,hsa04921,hsa04928,hsa04934,hsa05160,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05169,hsa05200,hsa05202,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05217,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" "Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Cell cycle|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|JAK-STAT signaling pathway|Oxytocin signaling pathway|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer" CDKN1B 958.9205294 975.9082219 941.9328369 0.965185881 -0.051121283 0.839731916 1 21.60200256 20.50105222 1027 cyclin dependent kinase inhibitor 1B "GO:0000079,GO:0000082,GO:0004860,GO:0004861,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005829,GO:0006977,GO:0007050,GO:0007507,GO:0008285,GO:0010942,GO:0019901,GO:0019903,GO:0030308,GO:0030332,GO:0031464,GO:0033673,GO:0042326,GO:0043231,GO:0044877,GO:0045732,GO:0045736,GO:0045786,GO:0045787,GO:0045892,GO:0045930,GO:0048102,GO:0051087,GO:0071285,GO:0071850,GO:1902806,GO:1904030,GO:1904706,GO:1905179" "regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|protein kinase inhibitor activity|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|endosome|cytosol|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|cell cycle arrest|heart development|negative regulation of cell population proliferation|positive regulation of cell death|protein kinase binding|protein phosphatase binding|negative regulation of cell growth|cyclin binding|Cul4A-RING E3 ubiquitin ligase complex|negative regulation of kinase activity|negative regulation of phosphorylation|intracellular membrane-bounded organelle|protein-containing complex binding|positive regulation of protein catabolic process|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of cell cycle|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle|autophagic cell death|chaperone binding|cellular response to lithium ion|mitotic cell cycle arrest|regulation of cell cycle G1/S phase transition|negative regulation of cyclin-dependent protein kinase activity|negative regulation of vascular associated smooth muscle cell proliferation|negative regulation of cardiac muscle tissue regeneration" "hsa01522,hsa04012,hsa04066,hsa04068,hsa04110,hsa04151,hsa04933,hsa04934,hsa05162,hsa05165,hsa05169,hsa05200,hsa05202,hsa05203,hsa05206,hsa05215,hsa05220,hsa05222,hsa05226" Endocrine resistance|ErbB signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Cell cycle|PI3K-Akt signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Measles|Human papillomavirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|MicroRNAs in cancer|Prostate cancer|Chronic myeloid leukemia|Small cell lung cancer|Gastric cancer CDKN1C 171.3373964 170.6278768 172.0469161 1.008316574 0.011948663 0.992639059 1 4.693864011 4.653702192 1028 cyclin dependent kinase inhibitor 1C "GO:0004860,GO:0004861,GO:0005515,GO:0005634,GO:0005737,GO:0007050,GO:0030511,GO:0033673,GO:0042326,GO:0044877,GO:0045736,GO:0045892,GO:0045893,GO:0045930,GO:0050680,GO:1904030" "protein kinase inhibitor activity|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|cytoplasm|cell cycle arrest|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of kinase activity|negative regulation of phosphorylation|protein-containing complex binding|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle|negative regulation of epithelial cell proliferation|negative regulation of cyclin-dependent protein kinase activity" hsa04110 Cell cycle CDKN2A 1696.822306 1536.691305 1856.953307 1.208410109 0.273110158 0.25028142 1 17.72814324 21.06438483 1029 cyclin dependent kinase inhibitor 2A "GO:0000082,GO:0001953,GO:0003723,GO:0004861,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007050,GO:0007265,GO:0008285,GO:0019901,GO:0030308,GO:0032088,GO:0034393,GO:0035985,GO:0035986,GO:0042326,GO:0045736,GO:0045892,GO:0051059,GO:0090398,GO:0090399,GO:2000111,GO:2000134,GO:2000774" "G1/S transition of mitotic cell cycle|negative regulation of cell-matrix adhesion|RNA binding|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|cytoplasm|cytosol|cell cycle arrest|Ras protein signal transduction|negative regulation of cell population proliferation|protein kinase binding|negative regulation of cell growth|negative regulation of NF-kappaB transcription factor activity|positive regulation of smooth muscle cell apoptotic process|senescence-associated heterochromatin focus|senescence-associated heterochromatin focus assembly|negative regulation of phosphorylation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|NF-kappaB binding|cellular senescence|replicative senescence|positive regulation of macrophage apoptotic process|negative regulation of G1/S transition of mitotic cell cycle|positive regulation of cellular senescence" "hsa01522,hsa01524,hsa04110,hsa04115,hsa04218,hsa04934,hsa05163,hsa05166,hsa05200,hsa05203,hsa05206,hsa05212,hsa05214,hsa05218,hsa05219,hsa05220,hsa05223,hsa05225" Endocrine resistance|Platinum drug resistance|Cell cycle|p53 signaling pathway|Cellular senescence|Cushing syndrome|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Viral carcinogenesis|MicroRNAs in cancer|Pancreatic cancer|Glioma|Melanoma|Bladder cancer|Chronic myeloid leukemia|Non-small cell lung cancer|Hepatocellular carcinoma CDKN2AIP 407.3540607 436.9738307 377.7342907 0.864432294 -0.210175125 0.468023233 1 6.642121966 5.645585741 55602 CDKN2A interacting protein "GO:0001652,GO:0002039,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006974,GO:0009967,GO:0030307,GO:0030308,GO:0031647" granular component|p53 binding|RNA binding|protein binding|nucleoplasm|nucleolus|cellular response to DNA damage stimulus|positive regulation of signal transduction|positive regulation of cell growth|negative regulation of cell growth|regulation of protein stability CDKN2AIPNL 681.6144024 609.6825352 753.5462695 1.235964992 0.30563788 0.235192225 1 13.16780103 16.002602 91368 CDKN2A interacting protein N-terminal like "GO:0005515,GO:0005654,GO:0005730" protein binding|nucleoplasm|nucleolus CDKN2B 260.5953382 293.3967149 227.7939616 0.776402563 -0.365123213 0.269920965 1 3.930231786 3.000380284 1030 cyclin dependent kinase inhibitor 2B "GO:0000079,GO:0000086,GO:0004861,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007050,GO:0008285,GO:0019901,GO:0030219,GO:0030511,GO:0031668,GO:0031670,GO:0042326,GO:0045736,GO:0045944,GO:0048536,GO:0050680,GO:0070316,GO:0090398,GO:2000134" regulation of cyclin-dependent protein serine/threonine kinase activity|G2/M transition of mitotic cell cycle|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|cytoplasm|cytosol|cell cycle arrest|negative regulation of cell population proliferation|protein kinase binding|megakaryocyte differentiation|positive regulation of transforming growth factor beta receptor signaling pathway|cellular response to extracellular stimulus|cellular response to nutrient|negative regulation of phosphorylation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription by RNA polymerase II|spleen development|negative regulation of epithelial cell proliferation|regulation of G0 to G1 transition|cellular senescence|negative regulation of G1/S transition of mitotic cell cycle "hsa04068,hsa04110,hsa04218,hsa04350,hsa04934,hsa05166,hsa05200,hsa05203,hsa05222,hsa05226" FoxO signaling pathway|Cell cycle|Cellular senescence|TGF-beta signaling pathway|Cushing syndrome|Human T-cell leukemia virus 1 infection|Pathways in cancer|Viral carcinogenesis|Small cell lung cancer|Gastric cancer CDKN2C 651.4071868 636.7332962 666.0810775 1.046091168 0.06500859 0.807108008 1 15.52365726 15.9674204 1031 cyclin dependent kinase inhibitor 2C "GO:0000079,GO:0000082,GO:0004861,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007050,GO:0008285,GO:0019901,GO:0030308,GO:0042326,GO:0045736,GO:0048709,GO:2000134" regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|cytoplasm|cytosol|cell cycle arrest|negative regulation of cell population proliferation|protein kinase binding|negative regulation of cell growth|negative regulation of phosphorylation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|oligodendrocyte differentiation|negative regulation of G1/S transition of mitotic cell cycle "hsa01522,hsa04110,hsa04934,hsa05166,hsa05202" Endocrine resistance|Cell cycle|Cushing syndrome|Human T-cell leukemia virus 1 infection|Transcriptional misregulation in cancer CDKN2D 291.6102243 249.6993318 333.5211167 1.335690866 0.417586147 0.188802839 1 9.351575026 12.2817965 1032 cyclin dependent kinase inhibitor 2D "GO:0000079,GO:0000082,GO:0000731,GO:0004861,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007050,GO:0007605,GO:0008285,GO:0009411,GO:0019901,GO:0030308,GO:0032526,GO:0033280,GO:0042326,GO:0043154,GO:0045736,GO:0048102,GO:0097129,GO:1902230,GO:2000134" regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|DNA synthesis involved in DNA repair|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cell cycle arrest|sensory perception of sound|negative regulation of cell population proliferation|response to UV|protein kinase binding|negative regulation of cell growth|response to retinoic acid|response to vitamin D|negative regulation of phosphorylation|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of cyclin-dependent protein serine/threonine kinase activity|autophagic cell death|cyclin D2-CDK4 complex|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of G1/S transition of mitotic cell cycle "hsa04068,hsa04110" FoxO signaling pathway|Cell cycle CDKN3 1383.664716 1389.992947 1377.336485 0.990894585 -0.013196508 0.959379635 1 73.88582559 71.98794302 1033 cyclin dependent kinase inhibitor 3 "GO:0000079,GO:0000082,GO:0004722,GO:0004725,GO:0005515,GO:0005737,GO:0005829,GO:0007050,GO:0008138,GO:0008285,GO:0035335,GO:0048471,GO:0106306,GO:0106307" regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein binding|cytoplasm|cytosol|cell cycle arrest|protein tyrosine/serine/threonine phosphatase activity|negative regulation of cell population proliferation|peptidyl-tyrosine dephosphorylation|perinuclear region of cytoplasm|protein serine phosphatase activity|protein threonine phosphatase activity CDNF 13.97135991 13.52538047 14.41733934 1.065947044 0.092135768 1 1 0.509403456 0.533910787 441549 cerebral dopamine neurotrophic factor "GO:0005615,GO:0005783,GO:0007165,GO:0008083,GO:0031175,GO:0071542" extracellular space|endoplasmic reticulum|signal transduction|growth factor activity|neuron projection development|dopaminergic neuron differentiation CDON 11.85090318 8.323311061 15.3784953 1.847641543 0.88568489 0.430428857 1 0.050987123 0.092629518 50937 "cell adhesion associated, oncogene regulated" "GO:0001708,GO:0001934,GO:0002088,GO:0005515,GO:0005886,GO:0005887,GO:0007155,GO:0007224,GO:0007520,GO:0009952,GO:0010172,GO:0014816,GO:0021987,GO:0043393,GO:0043410,GO:0045663,GO:0045666,GO:0045944,GO:0048643,GO:0051057,GO:0051149,GO:0060059,GO:0062023,GO:2000179" cell fate specification|positive regulation of protein phosphorylation|lens development in camera-type eye|protein binding|plasma membrane|integral component of plasma membrane|cell adhesion|smoothened signaling pathway|myoblast fusion|anterior/posterior pattern specification|embryonic body morphogenesis|skeletal muscle satellite cell differentiation|cerebral cortex development|regulation of protein binding|positive regulation of MAPK cascade|positive regulation of myoblast differentiation|positive regulation of neuron differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of skeletal muscle tissue development|positive regulation of small GTPase mediated signal transduction|positive regulation of muscle cell differentiation|embryonic retina morphogenesis in camera-type eye|collagen-containing extracellular matrix|positive regulation of neural precursor cell proliferation hsa04340 Hedgehog signaling pathway CDPF1 245.9704076 212.2444321 279.6963832 1.31780316 0.398134891 0.238319381 1 4.604510264 5.966301121 150383 cysteine rich DPF motif domain containing 1 GO:0005515 protein binding CDR2 1341.979578 1178.788929 1505.170227 1.276878489 0.352621242 0.142064131 1 23.37785159 29.35116519 1039 cerebellar degeneration related protein 2 "GO:0003674,GO:0005515" molecular_function|protein binding CDR2L 876.1032157 870.8264198 881.3800116 1.012119053 0.017379001 0.949335515 1 13.14321423 13.07989826 30850 cerebellar degeneration related protein 2 like "GO:0005515,GO:0042802" protein binding|identical protein binding CDRT1 4.122026567 7.282897178 0.961155956 0.131974396 -2.921670032 0.166282975 1 0.045448414 0.005897658 374286 CMT1A duplicated region transcript 1 "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process CDS1 153.9573313 168.547049 139.3676136 0.826876617 -0.274256023 0.500971808 1 1.996680628 1.62338113 1040 CDP-diacylglycerol synthase 1 "GO:0004142,GO:0004605,GO:0005515,GO:0005783,GO:0005789,GO:0006657,GO:0006661,GO:0007165,GO:0007602,GO:0016021,GO:0016024,GO:0045600,GO:0140042" diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|CDP-choline pathway|phosphatidylinositol biosynthetic process|signal transduction|phototransduction|integral component of membrane|CDP-diacylglycerol biosynthetic process|positive regulation of fat cell differentiation|lipid droplet formation "hsa00564,hsa04070" Glycerophospholipid metabolism|Phosphatidylinositol signaling system CDS2 2288.039587 1968.463066 2607.616109 1.324696487 0.405661849 0.08627539 1 10.47285973 13.64120859 8760 CDP-diacylglycerol synthase 2 "GO:0004605,GO:0005515,GO:0005743,GO:0005783,GO:0005789,GO:0006655,GO:0016020,GO:0016021,GO:0016024,GO:0140042" phosphatidate cytidylyltransferase activity|protein binding|mitochondrial inner membrane|endoplasmic reticulum|endoplasmic reticulum membrane|phosphatidylglycerol biosynthetic process|membrane|integral component of membrane|CDP-diacylglycerol biosynthetic process|lipid droplet formation "hsa00564,hsa04070" Glycerophospholipid metabolism|Phosphatidylinositol signaling system CDT1 1800.739162 1855.057953 1746.420372 0.941437096 -0.087063393 0.715011947 1 37.16255011 34.40075652 81620 chromatin licensing and DNA replication factor 1 "GO:0000076,GO:0000082,GO:0000083,GO:0000278,GO:0000776,GO:0000777,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0007059,GO:0016604,GO:0030174,GO:0031334,GO:0033044,GO:0033262,GO:0035563,GO:0045740,GO:0051301,GO:0051315,GO:0051383,GO:0070182,GO:0071163,GO:0072708,GO:1902426,GO:1902595,GO:1905341,GO:1905342,GO:2000105" DNA replication checkpoint|G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|mitotic cell cycle|kinetochore|condensed chromosome kinetochore|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|cytosol|chromosome segregation|nuclear body|regulation of DNA-dependent DNA replication initiation|positive regulation of protein-containing complex assembly|regulation of chromosome organization|regulation of nuclear cell cycle DNA replication|positive regulation of chromatin binding|positive regulation of DNA replication|cell division|attachment of mitotic spindle microtubules to kinetochore|kinetochore organization|DNA polymerase binding|DNA replication preinitiation complex assembly|response to sorbitol|deactivation of mitotic spindle assembly checkpoint|regulation of DNA replication origin binding|negative regulation of protein localization to kinetochore|positive regulation of protein localization to kinetochore|positive regulation of DNA-dependent DNA replication CDV3 3574.532588 3494.750232 3654.314945 1.045658403 0.064411627 0.787078234 1 41.75249536 42.92827592 55573 CDV3 homolog "GO:0003674,GO:0005737,GO:0005829,GO:0005886,GO:0008150" molecular_function|cytoplasm|cytosol|plasma membrane|biological_process CDYL 899.6414758 895.796353 903.4865986 1.008584815 0.012332409 0.965350893 1 11.55037568 11.45459435 9425 chromodomain Y like "GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005694,GO:0005737,GO:0007283,GO:0007286,GO:0016607,GO:0030674,GO:0035064,GO:0045892,GO:0060816,GO:0120092,GO:0120094" "chromatin binding|transcription corepressor activity|protein binding|nucleus|chromosome|cytoplasm|spermatogenesis|spermatid development|nuclear speck|protein-macromolecule adaptor activity|methylated histone binding|negative regulation of transcription, DNA-templated|random inactivation of X chromosome|crotonyl-CoA hydratase activity|negative regulation of peptidyl-lysine crotonylation" CDYL2 1611.656208 1496.115163 1727.197253 1.154454747 0.207211623 0.384244019 1 8.426904118 9.565686536 124359 chromodomain Y like 2 "GO:0003714,GO:0003824,GO:0005515,GO:0005634,GO:0045892" "transcription corepressor activity|catalytic activity|protein binding|nucleus|negative regulation of transcription, DNA-templated" CEACAM19 23.30048631 18.72744989 27.87352272 1.48837791 0.573740884 0.49496389 1 0.27158956 0.397463695 56971 CEA cell adhesion molecule 19 "GO:0005515,GO:0016021" protein binding|integral component of membrane CEBPA 10.60731406 13.52538047 7.689247648 0.56850509 -0.814754828 0.49718369 1 0.277518146 0.155130403 1050 CCAAT enhancer binding protein alpha "GO:0000050,GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001889,GO:0001892,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0006091,GO:0006355,GO:0006357,GO:0007005,GO:0007219,GO:0008134,GO:0008203,GO:0008285,GO:0016032,GO:0019221,GO:0019900,GO:0030099,GO:0030225,GO:0030324,GO:0030851,GO:0032436,GO:0042593,GO:0042803,GO:0043032,GO:0043231,GO:0045444,GO:0045600,GO:0045669,GO:0045736,GO:0045892,GO:0045944,GO:0045945,GO:0048469,GO:0048839,GO:0050729,GO:0050872,GO:0050873,GO:0055088,GO:0070102,GO:0071285,GO:0071356,GO:0071407,GO:0090575" "urea cycle|negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|liver development|embryonic placenta development|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|generation of precursor metabolites and energy|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|mitochondrion organization|Notch signaling pathway|transcription factor binding|cholesterol metabolic process|negative regulation of cell population proliferation|viral process|cytokine-mediated signaling pathway|kinase binding|myeloid cell differentiation|macrophage differentiation|lung development|granulocyte differentiation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|glucose homeostasis|protein homodimerization activity|positive regulation of macrophage activation|intracellular membrane-bounded organelle|fat cell differentiation|positive regulation of fat cell differentiation|positive regulation of osteoblast differentiation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase III|cell maturation|inner ear development|positive regulation of inflammatory response|white fat cell differentiation|brown fat cell differentiation|lipid homeostasis|interleukin-6-mediated signaling pathway|cellular response to lithium ion|cellular response to tumor necrosis factor|cellular response to organic cyclic compound|RNA polymerase II transcription regulator complex" "hsa04932,hsa05200,hsa05202,hsa05221" Non-alcoholic fatty liver disease|Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia TF_bZIP CEBPB 3398.761778 3195.111034 3602.412523 1.127476474 0.173097331 0.46582223 1 80.89051399 89.67600703 1051 CCAAT enhancer binding protein beta "GO:0000122,GO:0000779,GO:0000785,GO:0000977,GO:0000978,GO:0000979,GO:0000981,GO:0001227,GO:0001228,GO:0001541,GO:0001892,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006357,GO:0006953,GO:0006954,GO:0006955,GO:0007613,GO:0016363,GO:0019900,GO:0030182,GO:0032675,GO:0032753,GO:0033598,GO:0034976,GO:0035035,GO:0035259,GO:0036488,GO:0042130,GO:0042742,GO:0042803,GO:0042826,GO:0043524,GO:0044389,GO:0045595,GO:0045600,GO:0045669,GO:0045670,GO:0045893,GO:0045944,GO:0046982,GO:0050729,GO:0050873,GO:0060644,GO:0070059,GO:0070169,GO:0071222,GO:0071230,GO:0071347,GO:0071407,GO:0072574,GO:0097421,GO:0120162,GO:1901329,GO:1990440,GO:1990837,GO:2000120,GO:2001198" "negative regulation of transcription by RNA polymerase II|condensed chromosome, centromeric region|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|ovarian follicle development|embryonic placenta development|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|acute-phase response|inflammatory response|immune response|memory|nuclear matrix|kinase binding|neuron differentiation|regulation of interleukin-6 production|positive regulation of interleukin-4 production|mammary gland epithelial cell proliferation|response to endoplasmic reticulum stress|histone acetyltransferase binding|glucocorticoid receptor binding|CHOP-C/EBP complex|negative regulation of T cell proliferation|defense response to bacterium|protein homodimerization activity|histone deacetylase binding|negative regulation of neuron apoptotic process|ubiquitin-like protein ligase binding|regulation of cell differentiation|positive regulation of fat cell differentiation|positive regulation of osteoblast differentiation|regulation of osteoclast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|positive regulation of inflammatory response|brown fat cell differentiation|mammary gland epithelial cell differentiation|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|positive regulation of biomineral tissue development|cellular response to lipopolysaccharide|cellular response to amino acid stimulus|cellular response to interleukin-1|cellular response to organic cyclic compound|hepatocyte proliferation|liver regeneration|positive regulation of cold-induced thermogenesis|regulation of odontoblast differentiation|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|sequence-specific double-stranded DNA binding|positive regulation of sodium-dependent phosphate transport|regulation of dendritic cell differentiation" "hsa04657,hsa04668,hsa05152,hsa05202" IL-17 signaling pathway|TNF signaling pathway|Tuberculosis|Transcriptional misregulation in cancer TF_bZIP CEBPD 157.2370888 178.9511878 135.5229898 0.757318191 -0.401028512 0.316381426 1 7.628031945 5.680179635 1052 CCAAT enhancer binding protein delta "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005654,GO:0006357,GO:0006366,GO:0019221,GO:0045595,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|cytokine-mediated signaling pathway|regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" TF_bZIP CEBPG 950.6066648 1035.211813 866.0015164 0.836545242 -0.25748453 0.29752117 1 12.85420005 10.57318099 1054 CCAAT enhancer binding protein gamma "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001889,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006955,GO:0008134,GO:0016071,GO:0030183,GO:0032729,GO:0042267,GO:0042802,GO:0043353,GO:0043388,GO:0043433,GO:0043565,GO:0044377,GO:0044877,GO:0045739,GO:0045944,GO:0051091,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|liver development|DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|immune response|transcription factor binding|mRNA metabolic process|B cell differentiation|positive regulation of interferon-gamma production|natural killer cell mediated cytotoxicity|identical protein binding|enucleate erythrocyte differentiation|positive regulation of DNA binding|negative regulation of DNA-binding transcription factor activity|sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending|protein-containing complex binding|positive regulation of DNA repair|positive regulation of transcription by RNA polymerase II|positive regulation of DNA-binding transcription factor activity|sequence-specific double-stranded DNA binding" hsa05152 Tuberculosis CEBPZ 1101.155905 1114.283268 1088.028542 0.976438015 -0.034399632 0.89147016 1 17.77263899 17.06348664 10153 CCAAT enhancer binding protein zeta "GO:0003677,GO:0003713,GO:0003723,GO:0005634,GO:0045944" DNA binding|transcription coactivator activity|RNA binding|nucleus|positive regulation of transcription by RNA polymerase II other CEBPZOS 860.1699149 856.2606254 864.0792044 1.009131074 0.013113575 0.963234566 1 12.35389452 12.25808552 100505876 CEBPZ opposite strand "GO:0016021,GO:0031966" integral component of membrane|mitochondrial membrane CELF1 1574.244739 1611.601104 1536.888374 0.95364068 -0.068482315 0.77574771 1 13.85218053 12.98895136 10658 CUGBP Elav-like family member 1 "GO:0000381,GO:0000900,GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006376,GO:0006397,GO:0007281,GO:0008285,GO:0009792,GO:0010494,GO:0010628,GO:0010629,GO:0010942,GO:0016020,GO:0016246,GO:0016441,GO:0036002,GO:0042835,GO:0043484,GO:0050727,GO:0061157,GO:0097356,GO:1990904" "regulation of alternative mRNA splicing, via spliceosome|translation repressor activity, mRNA regulatory element binding|RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|cytoplasm|mRNA splice site selection|mRNA processing|germ cell development|negative regulation of cell population proliferation|embryo development ending in birth or egg hatching|cytoplasmic stress granule|positive regulation of gene expression|negative regulation of gene expression|positive regulation of cell death|membrane|RNA interference|posttranscriptional gene silencing|pre-mRNA binding|BRE binding|regulation of RNA splicing|regulation of inflammatory response|mRNA destabilization|perinucleolar compartment|ribonucleoprotein complex" CELF2 4.444088692 3.121241648 5.766935736 1.847641543 0.88568489 0.705170935 1 0.014295823 0.025971561 10659 CUGBP Elav-like family member 2 "GO:0000381,GO:0003723,GO:0003729,GO:0003730,GO:0005634,GO:0005654,GO:0005737,GO:0006376,GO:0006396,GO:0008016,GO:0036002,GO:0043231,GO:0090543,GO:1990904" "regulation of alternative mRNA splicing, via spliceosome|RNA binding|mRNA binding|mRNA 3'-UTR binding|nucleus|nucleoplasm|cytoplasm|mRNA splice site selection|RNA processing|regulation of heart contraction|pre-mRNA binding|intracellular membrane-bounded organelle|Flemming body|ribonucleoprotein complex" CELF6 4.042768641 5.202069413 2.883467868 0.554292463 -0.851280704 0.745112452 1 0.077679038 0.042336407 60677 CUGBP Elav-like family member 6 "GO:0000381,GO:0003723,GO:0003729,GO:0005634,GO:0005737,GO:0006376,GO:1990904" "regulation of alternative mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|cytoplasm|mRNA splice site selection|ribonucleoprotein complex" CELSR1 2013.078558 2143.252598 1882.904518 0.878526647 -0.18684205 0.430106171 1 9.341836984 8.069718806 9620 cadherin EGF LAG seven-pass G-type receptor 1 "GO:0001736,GO:0001764,GO:0001843,GO:0004930,GO:0005509,GO:0005654,GO:0005886,GO:0007156,GO:0007186,GO:0007266,GO:0007417,GO:0016021,GO:0032956,GO:0042249,GO:0045176,GO:0048105,GO:0060071,GO:0060488,GO:0060489,GO:0060490,GO:0090251,GO:0098609" "establishment of planar polarity|neuron migration|neural tube closure|G protein-coupled receptor activity|calcium ion binding|nucleoplasm|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|G protein-coupled receptor signaling pathway|Rho protein signal transduction|central nervous system development|integral component of membrane|regulation of actin cytoskeleton organization|establishment of planar polarity of embryonic epithelium|apical protein localization|establishment of body hair planar orientation|Wnt signaling pathway, planar cell polarity pathway|orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis|planar dichotomous subdivision of terminal units involved in lung branching morphogenesis|lateral sprouting involved in lung morphogenesis|protein localization involved in establishment of planar polarity|cell-cell adhesion" CELSR2 1162.529035 1463.862333 861.1957366 0.588303775 -0.765366801 0.001671041 0.264245783 7.092477734 4.102709763 1952 cadherin EGF LAG seven-pass G-type receptor 2 "GO:0001764,GO:0003341,GO:0004930,GO:0005509,GO:0005737,GO:0005886,GO:0006355,GO:0007156,GO:0007186,GO:0016021,GO:0016055,GO:0021591,GO:0021999,GO:0022407,GO:0032880,GO:0033326,GO:0048813,GO:0060071,GO:0060271,GO:0098609" "neuron migration|cilium movement|G protein-coupled receptor activity|calcium ion binding|cytoplasm|plasma membrane|regulation of transcription, DNA-templated|homophilic cell adhesion via plasma membrane adhesion molecules|G protein-coupled receptor signaling pathway|integral component of membrane|Wnt signaling pathway|ventricular system development|neural plate anterior/posterior regionalization|regulation of cell-cell adhesion|regulation of protein localization|cerebrospinal fluid secretion|dendrite morphogenesis|Wnt signaling pathway, planar cell polarity pathway|cilium assembly|cell-cell adhesion" CELSR3 286.9032097 302.7604398 271.0459796 0.895248995 -0.1596391 0.624542989 1 1.354040746 1.191919032 1951 cadherin EGF LAG seven-pass G-type receptor 3 "GO:0004930,GO:0005509,GO:0005515,GO:0005886,GO:0007156,GO:0007186,GO:0007275,GO:0016021,GO:0060071,GO:0098609" "G protein-coupled receptor activity|calcium ion binding|protein binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|G protein-coupled receptor signaling pathway|multicellular organism development|integral component of membrane|Wnt signaling pathway, planar cell polarity pathway|cell-cell adhesion" CEMIP2 678.5416218 781.3508259 575.7324176 0.7368424 -0.440572015 0.086841314 1 6.605299781 4.785621201 23670 cell migration inducing hyaluronidase 2 "GO:0001525,GO:0004415,GO:0005509,GO:0005886,GO:0005887,GO:0016021,GO:0030214,GO:0043231,GO:0045296,GO:0070062,GO:1903670" angiogenesis|hyalurononglucosaminidase activity|calcium ion binding|plasma membrane|integral component of plasma membrane|integral component of membrane|hyaluronan catabolic process|intracellular membrane-bounded organelle|cadherin binding|extracellular exosome|regulation of sprouting angiogenesis CENATAC 288.3499741 290.2754733 286.4244749 0.986733297 -0.019267901 0.963916231 1 10.49557487 10.18303399 338657 centrosomal AT-AC splicing factor "GO:0005515,GO:0005737,GO:0005813,GO:0010826,GO:0042176" protein binding|cytoplasm|centrosome|negative regulation of centrosome duplication|regulation of protein catabolic process CEND1 8.328341479 4.161655531 12.49502743 3.002417508 1.586124608 0.225847079 1 0.138380004 0.408522144 51286 cell cycle exit and neuronal differentiation 1 "GO:0003674,GO:0005515,GO:0005739,GO:0007628,GO:0008150,GO:0016021,GO:0021686,GO:0021702,GO:0021933,GO:0021941,GO:0031982" molecular_function|protein binding|mitochondrion|adult walking behavior|biological_process|integral component of membrane|cerebellar granular layer maturation|cerebellar Purkinje cell differentiation|radial glia guided migration of cerebellar granule cell|negative regulation of cerebellar granule cell precursor proliferation|vesicle CENPA 516.9447326 588.8742576 445.0152076 0.755704978 -0.404104969 0.136074877 1 22.62572845 16.81225745 1058 centromere protein A "GO:0000132,GO:0000281,GO:0000775,GO:0000778,GO:0000779,GO:0000786,GO:0000939,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005721,GO:0005829,GO:0016032,GO:0034080,GO:0046982,GO:0051382,GO:0071459" "establishment of mitotic spindle orientation|mitotic cytokinesis|chromosome, centromeric region|condensed nuclear chromosome kinetochore|condensed chromosome, centromeric region|nucleosome|condensed chromosome inner kinetochore|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|pericentric heterochromatin|cytosol|viral process|CENP-A containing nucleosome assembly|protein heterodimerization activity|kinetochore assembly|protein localization to chromosome, centromeric region" chromosome_remodelling_factor CENPB 1959.705449 2016.322105 1903.088793 0.943841655 -0.08338325 0.726080592 1 37.23439615 34.55529733 1059 centromere protein B "GO:0000775,GO:0000779,GO:0003677,GO:0003682,GO:0003696,GO:0005634,GO:0005654,GO:0005694,GO:0005721,GO:0016604,GO:0019237,GO:0043565" "chromosome, centromeric region|condensed chromosome, centromeric region|DNA binding|chromatin binding|satellite DNA binding|nucleus|nucleoplasm|chromosome|pericentric heterochromatin|nuclear body|centromeric DNA binding|sequence-specific DNA binding" CENPBD1 99.64257334 92.59683556 106.6883111 1.152180963 0.204367325 0.677113172 1 1.826209508 2.068914166 92806 CENPB DNA-binding domain containing 1 "GO:0003677,GO:0005634" DNA binding|nucleus CENPC 520.6509622 534.7727357 506.5291888 0.947185889 -0.078280507 0.778377219 1 3.932190415 3.662190553 1060 centromere protein C "GO:0000278,GO:0000776,GO:0000778,GO:0000779,GO:0003677,GO:0005515,GO:0005654,GO:0005721,GO:0005829,GO:0007059,GO:0016604,GO:0019237,GO:0030496,GO:0034080,GO:0042802,GO:0051301,GO:0051315,GO:0051382,GO:0051455" "mitotic cell cycle|kinetochore|condensed nuclear chromosome kinetochore|condensed chromosome, centromeric region|DNA binding|protein binding|nucleoplasm|pericentric heterochromatin|cytosol|chromosome segregation|nuclear body|centromeric DNA binding|midbody|CENP-A containing nucleosome assembly|identical protein binding|cell division|attachment of mitotic spindle microtubules to kinetochore|kinetochore assembly|monopolar spindle attachment to meiosis I kinetochore" CENPE 1252.570724 1430.569089 1074.572359 0.751150271 -0.41282654 0.087097945 1 8.938864651 6.602073703 1062 centromere protein E "GO:0000278,GO:0000775,GO:0000776,GO:0000777,GO:0000779,GO:0003777,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005828,GO:0005829,GO:0005874,GO:0006890,GO:0007018,GO:0007052,GO:0007059,GO:0007079,GO:0007080,GO:0007275,GO:0008017,GO:0008574,GO:0015630,GO:0016020,GO:0019886,GO:0030071,GO:0030496,GO:0043515,GO:0045860,GO:0051233,GO:0051301,GO:0051310,GO:0051315,GO:0051382,GO:0099606,GO:0099607,GO:1990023" "mitotic cell cycle|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|condensed chromosome, centromeric region|microtubule motor activity|protein binding|ATP binding|nucleus|nucleoplasm|chromosome|kinetochore microtubule|cytosol|microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|mitotic spindle organization|chromosome segregation|mitotic chromosome movement towards spindle pole|mitotic metaphase plate congression|multicellular organism development|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|microtubule cytoskeleton|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|regulation of mitotic metaphase/anaphase transition|midbody|kinetochore binding|positive regulation of protein kinase activity|spindle midzone|cell division|metaphase plate congression|attachment of mitotic spindle microtubules to kinetochore|kinetochore assembly|microtubule plus-end directed mitotic chromosome migration|lateral attachment of mitotic spindle microtubules to kinetochore|mitotic spindle midzone" CENPF 4961.048862 6057.289625 3864.808099 0.638042481 -0.648275613 0.007073776 0.504530246 32.55124504 20.42153476 1063 centromere protein F "GO:0000278,GO:0000775,GO:0000776,GO:0000785,GO:0000922,GO:0000940,GO:0001822,GO:0003682,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005813,GO:0005819,GO:0005829,GO:0005930,GO:0007059,GO:0007094,GO:0007517,GO:0008017,GO:0008022,GO:0008134,GO:0010389,GO:0015031,GO:0016202,GO:0016363,GO:0021591,GO:0030154,GO:0030496,GO:0036064,GO:0042493,GO:0042803,GO:0045120,GO:0045892,GO:0048471,GO:0051301,GO:0051310,GO:0051382,GO:0051726,GO:0070840,GO:0071897,GO:0097539" "mitotic cell cycle|chromosome, centromeric region|kinetochore|chromatin|spindle pole|condensed chromosome outer kinetochore|kidney development|chromatin binding|protein binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|centrosome|spindle|cytosol|axoneme|chromosome segregation|mitotic spindle assembly checkpoint|muscle organ development|microtubule binding|protein C-terminus binding|transcription factor binding|regulation of G2/M transition of mitotic cell cycle|protein transport|regulation of striated muscle tissue development|nuclear matrix|ventricular system development|cell differentiation|midbody|ciliary basal body|response to drug|protein homodimerization activity|pronucleus|negative regulation of transcription, DNA-templated|perinuclear region of cytoplasm|cell division|metaphase plate congression|kinetochore assembly|regulation of cell cycle|dynein complex binding|DNA biosynthetic process|ciliary transition fiber" CENPH 825.0688296 704.3601985 945.7774607 1.342746882 0.425187372 0.08992775 1 27.76248836 36.65419793 64946 centromere protein H "GO:0000776,GO:0000777,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005829,GO:0007052,GO:0007059,GO:0034080,GO:0043515,GO:0051382,GO:0051383" kinetochore|condensed chromosome kinetochore|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|cytosol|mitotic spindle organization|chromosome segregation|CENP-A containing nucleosome assembly|kinetochore binding|kinetochore assembly|kinetochore organization CENPI 1609.049529 1604.318207 1613.78085 1.005898233 0.008484355 0.974472277 1 12.88868194 12.74775565 2491 centromere protein I "GO:0000776,GO:0005515,GO:0005654,GO:0005829,GO:0007548,GO:0016604,GO:0034080" kinetochore|protein binding|nucleoplasm|cytosol|sex differentiation|nuclear body|CENP-A containing nucleosome assembly CENPJ 1113.026316 1173.58686 1052.465772 0.8967941 -0.157151308 0.520188627 1 8.344281073 7.357882459 55835 centromere protein J "GO:0000086,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0005874,GO:0005886,GO:0007020,GO:0007099,GO:0008275,GO:0010389,GO:0015631,GO:0019901,GO:0019904,GO:0030954,GO:0042802,GO:0043015,GO:0045893,GO:0046427,GO:0046599,GO:0046785,GO:0051301,GO:0060271,GO:0061511,GO:0097711,GO:1903724,GO:1904951" "G2/M transition of mitotic cell cycle|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|centriole|cytosol|microtubule|plasma membrane|microtubule nucleation|centriole replication|gamma-tubulin small complex|regulation of G2/M transition of mitotic cell cycle|tubulin binding|protein kinase binding|protein domain specific binding|astral microtubule nucleation|identical protein binding|gamma-tubulin binding|positive regulation of transcription, DNA-templated|positive regulation of receptor signaling pathway via JAK-STAT|regulation of centriole replication|microtubule polymerization|cell division|cilium assembly|centriole elongation|ciliary basal body-plasma membrane docking|positive regulation of centriole elongation|positive regulation of establishment of protein localization" CENPK 829.6613733 736.6130289 922.7097178 1.252638335 0.324969936 0.19478601 1 7.486513715 9.220967714 64105 centromere protein K "GO:0000070,GO:0000941,GO:0005515,GO:0005654,GO:0005829,GO:0034080,GO:0051382" mitotic sister chromatid segregation|condensed nuclear chromosome inner kinetochore|protein binding|nucleoplasm|cytosol|CENP-A containing nucleosome assembly|kinetochore assembly CENPL 333.3852954 337.094098 329.6764929 0.977995447 -0.032100347 0.926437276 1 5.705706456 5.486778598 91687 centromere protein L "GO:0000775,GO:0005515,GO:0005654,GO:0005829,GO:0034080" "chromosome, centromeric region|protein binding|nucleoplasm|cytosol|CENP-A containing nucleosome assembly" CENPM 364.369999 368.3065145 360.4334835 0.978623699 -0.031173875 0.926074514 1 11.07371367 10.65565613 79019 centromere protein M "GO:0000777,GO:0005654,GO:0005829,GO:0034080" condensed chromosome kinetochore|nucleoplasm|cytosol|CENP-A containing nucleosome assembly CENPN 958.2172689 932.2108388 984.2236989 1.055795168 0.078329968 0.754246783 1 19.09803422 19.8262015 55839 centromere protein N "GO:0000777,GO:0005654,GO:0005829,GO:0007059,GO:0034080,GO:0051382" condensed chromosome kinetochore|nucleoplasm|cytosol|chromosome segregation|CENP-A containing nucleosome assembly|kinetochore assembly CENPO 1099.282669 1191.273896 1007.291442 0.845558226 -0.242023991 0.321277628 1 15.48370637 12.87329212 79172 centromere protein O "GO:0000778,GO:0005515,GO:0005654,GO:0005829,GO:0016604,GO:0031511,GO:0034080" condensed nuclear chromosome kinetochore|protein binding|nucleoplasm|cytosol|nuclear body|Mis6-Sim4 complex|CENP-A containing nucleosome assembly CENPP 149.8007062 147.7387713 151.862641 1.027913253 0.039718519 0.939712726 1 1.52919835 1.545579913 401541 centromere protein P "GO:0000775,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0034080" "chromosome, centromeric region|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|CENP-A containing nucleosome assembly" CENPQ 286.7050649 297.5583704 275.8517594 0.927050914 -0.10927952 0.741410915 1 8.807622485 8.028482345 55166 centromere protein Q "GO:0000776,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0015629,GO:0034080,GO:0051310,GO:1905342" kinetochore|protein binding|nucleus|nucleoplasm|cytosol|actin cytoskeleton|CENP-A containing nucleosome assembly|metaphase plate congression|positive regulation of protein localization to kinetochore CENPS 7.406814487 5.202069413 9.61155956 1.847641543 0.88568489 0.555147706 1 0.306767827 0.557312402 378708 centromere protein S "GO:0000712,GO:0000777,GO:0003677,GO:0003682,GO:0003690,GO:0005515,GO:0005654,GO:0005829,GO:0006281,GO:0006974,GO:0031297,GO:0031398,GO:0034080,GO:0036297,GO:0043240,GO:0046982,GO:0051301,GO:0051382,GO:0071821" resolution of meiotic recombination intermediates|condensed chromosome kinetochore|DNA binding|chromatin binding|double-stranded DNA binding|protein binding|nucleoplasm|cytosol|DNA repair|cellular response to DNA damage stimulus|replication fork processing|positive regulation of protein ubiquitination|CENP-A containing nucleosome assembly|interstrand cross-link repair|Fanconi anaemia nuclear complex|protein heterodimerization activity|cell division|kinetochore assembly|FANCM-MHF complex hsa03460 Fanconi anemia pathway CENPS-CORT 82.78774556 79.07145508 86.50403604 1.093998282 0.129610473 0.817008256 1 2.145347346 2.30773234 100526739 CENPS-CORT readthrough hsa03460 Fanconi anemia pathway CENPT 681.0791042 646.0970211 716.0611872 1.108287399 0.148332047 0.567081291 1 13.55918621 14.77601078 80152 centromere protein T "GO:0000278,GO:0000775,GO:0000776,GO:0000778,GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0007059,GO:0016604,GO:0034080,GO:0046982,GO:0051276,GO:0051301,GO:0051382,GO:1903394" "mitotic cell cycle|chromosome, centromeric region|kinetochore|condensed nuclear chromosome kinetochore|DNA binding|protein binding|nucleoplasm|cytosol|chromosome segregation|nuclear body|CENP-A containing nucleosome assembly|protein heterodimerization activity|chromosome organization|cell division|kinetochore assembly|protein localization to kinetochore involved in kinetochore assembly" CENPU 909.4014904 924.9279417 893.8750391 0.966426679 -0.049267813 0.846656081 1 18.65521705 17.72721024 79682 centromere protein U "GO:0000777,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0016032,GO:0034080,GO:0034451,GO:0043009" condensed chromosome kinetochore|protein binding|nucleus|nucleoplasm|cytosol|viral process|CENP-A containing nucleosome assembly|centriolar satellite|chordate embryonic development CENPV 148.3092825 171.6682906 124.9502743 0.72785879 -0.458269511 0.261800268 1 8.09330491 5.79220884 201161 centromere protein V "GO:0000776,GO:0000777,GO:0001667,GO:0003674,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0007049,GO:0015630,GO:0016846,GO:0030496,GO:0031508,GO:0031965,GO:0032467,GO:0033044,GO:0034508,GO:0046872,GO:0051233,GO:0051301" kinetochore|condensed chromosome kinetochore|ameboidal-type cell migration|molecular_function|protein binding|nucleus|nucleoplasm|cytosol|cell cycle|microtubule cytoskeleton|carbon-sulfur lyase activity|midbody|pericentric heterochromatin assembly|nuclear membrane|positive regulation of cytokinesis|regulation of chromosome organization|centromere complex assembly|metal ion binding|spindle midzone|cell division CENPW 381.7601249 345.417409 418.1028409 1.210427818 0.275517049 0.348759713 1 15.01163866 17.86644624 387103 centromere protein W "GO:0000278,GO:0000775,GO:0000776,GO:0000777,GO:0003677,GO:0005515,GO:0005654,GO:0005730,GO:0007059,GO:0016363,GO:0034080,GO:0046982,GO:0051276,GO:0051301,GO:0051382" "mitotic cell cycle|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|DNA binding|protein binding|nucleoplasm|nucleolus|chromosome segregation|nuclear matrix|CENP-A containing nucleosome assembly|protein heterodimerization activity|chromosome organization|cell division|kinetochore assembly" CENPX 732.302803 640.8949517 823.7106543 1.285250652 0.362049744 0.155023684 1 38.17342149 48.24142178 201254 centromere protein X "GO:0000712,GO:0000777,GO:0003677,GO:0003690,GO:0005515,GO:0005654,GO:0031297,GO:0031398,GO:0034080,GO:0036297,GO:0043240,GO:0051301,GO:0051382,GO:0071821" resolution of meiotic recombination intermediates|condensed chromosome kinetochore|DNA binding|double-stranded DNA binding|protein binding|nucleoplasm|replication fork processing|positive regulation of protein ubiquitination|CENP-A containing nucleosome assembly|interstrand cross-link repair|Fanconi anaemia nuclear complex|cell division|kinetochore assembly|FANCM-MHF complex hsa03460 Fanconi anemia pathway CEP104 1191.984529 1215.203415 1168.765642 0.961786009 -0.056212155 0.819513161 1 9.739175973 9.210259077 9731 centrosomal protein 104 "GO:0000922,GO:0005515,GO:0005737,GO:0005814,GO:0005929" spindle pole|protein binding|cytoplasm|centriole|cilium CEP112 412.9083748 368.3065145 457.5102351 1.242199682 0.312897103 0.276131229 1 2.061008887 2.517343362 201134 centrosomal protein 112 "GO:0005737,GO:0005813,GO:0005886,GO:0060077,GO:0097120" cytoplasm|centrosome|plasma membrane|inhibitory synapse|receptor localization to synapse CEP120 1178.761089 1233.930865 1123.591313 0.910578821 -0.13514419 0.578886764 1 10.56685212 9.460941414 153241 centrosomal protein 120 "GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0007098,GO:0008022,GO:0010825,GO:0021987,GO:0022008,GO:0022027,GO:0030953,GO:0045724,GO:1903724,GO:1904951" protein binding|cytoplasm|centrosome|centriole|centrosome cycle|protein C-terminus binding|positive regulation of centrosome duplication|cerebral cortex development|neurogenesis|interkinetic nuclear migration|astral microtubule organization|positive regulation of cilium assembly|positive regulation of centriole elongation|positive regulation of establishment of protein localization CEP126 313.0670422 371.4277561 254.7063283 0.685749312 -0.544246824 0.079372406 1 2.56434886 1.729074344 57562 centrosomal protein 126 "GO:0005515,GO:0005737,GO:0005813,GO:0007052,GO:0030496,GO:0031122,GO:0060271,GO:0097546,GO:1905515" protein binding|cytoplasm|centrosome|mitotic spindle organization|midbody|cytoplasmic microtubule organization|cilium assembly|ciliary base|non-motile cilium assembly CEP128 463.4281987 420.3272086 506.5291888 1.205083036 0.269132559 0.334947354 1 1.782446611 2.112052367 145508 centrosomal protein 128 "GO:0000922,GO:0005737,GO:0005814,GO:0008104,GO:0120103" spindle pole|cytoplasm|centriole|protein localization|centriolar subdistal appendage CEP131 753.5765674 719.9664068 787.186728 1.093365913 0.128776304 0.614491479 1 10.50390484 11.29243208 22994 centrosomal protein 131 "GO:0000086,GO:0001669,GO:0002177,GO:0005515,GO:0005813,GO:0005829,GO:0007275,GO:0007288,GO:0008284,GO:0010389,GO:0010824,GO:0015630,GO:0034451,GO:0035735,GO:0035869,GO:0036064,GO:0042803,GO:0043231,GO:0044877,GO:0045171,GO:0060271,GO:0071539,GO:0090316,GO:0097711,GO:0120212,GO:1905198,GO:1905515,GO:1990953" G2/M transition of mitotic cell cycle|acrosomal vesicle|manchette|protein binding|centrosome|cytosol|multicellular organism development|sperm axoneme assembly|positive regulation of cell population proliferation|regulation of G2/M transition of mitotic cell cycle|regulation of centrosome duplication|microtubule cytoskeleton|centriolar satellite|intraciliary transport involved in cilium assembly|ciliary transition zone|ciliary basal body|protein homodimerization activity|intracellular membrane-bounded organelle|protein-containing complex binding|intercellular bridge|cilium assembly|protein localization to centrosome|positive regulation of intracellular protein transport|ciliary basal body-plasma membrane docking|sperm head-tail coupling apparatus|manchette assembly|non-motile cilium assembly|intramanchette transport CEP135 278.9214681 332.9324424 224.9104937 0.675543939 -0.565878485 0.079627347 1 3.099248657 2.05864377 9662 centrosomal protein 135 "GO:0000086,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0007099,GO:0008022,GO:0010389,GO:0010457,GO:0097711,GO:1902857,GO:1904951" G2/M transition of mitotic cell cycle|protein binding|centrosome|centriole|cytosol|centriole replication|protein C-terminus binding|regulation of G2/M transition of mitotic cell cycle|centriole-centriole cohesion|ciliary basal body-plasma membrane docking|positive regulation of non-motile cilium assembly|positive regulation of establishment of protein localization CEP152 537.0497497 586.7934298 487.3060697 0.830455907 -0.268024525 0.31986372 1 2.696872793 2.202156699 22995 centrosomal protein 152 "GO:0000086,GO:0000242,GO:0005515,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0007099,GO:0010389,GO:0019901,GO:0051298,GO:0097711,GO:0098535,GO:0098536" G2/M transition of mitotic cell cycle|pericentriolar material|protein binding|nucleoplasm|centrosome|centriole|cytosol|centriole replication|regulation of G2/M transition of mitotic cell cycle|protein kinase binding|centrosome duplication|ciliary basal body-plasma membrane docking|de novo centriole assembly involved in multi-ciliated epithelial cell differentiation|deuterosome CEP162 203.8380614 216.4060876 191.2700352 0.883847758 -0.178130208 0.629554319 1 1.785037891 1.551301036 22832 centrosomal protein 162 "GO:0005515,GO:0005634,GO:0005813,GO:0005814,GO:0005819,GO:0005829,GO:0005879,GO:0060271,GO:0097711" protein binding|nucleus|centrosome|centriole|spindle|cytosol|axonemal microtubule|cilium assembly|ciliary basal body-plasma membrane docking CEP164 817.3141865 866.6647642 767.9636088 0.886113801 -0.174436102 0.488721653 1 5.313913787 4.629938088 22897 centrosomal protein 164 "GO:0000086,GO:0005515,GO:0005615,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0006281,GO:0010389,GO:0051301,GO:0060271,GO:0097539,GO:0097711" G2/M transition of mitotic cell cycle|protein binding|extracellular space|nucleoplasm|centrosome|centriole|cytosol|DNA repair|regulation of G2/M transition of mitotic cell cycle|cell division|cilium assembly|ciliary transition fiber|ciliary basal body-plasma membrane docking CEP170 5197.820819 5144.84665 5250.794988 1.020593099 0.029407792 0.903425921 1 28.65786555 28.75859382 9859 centrosomal protein 170 "GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0005874,GO:0072686,GO:0120103" protein binding|centrosome|centriole|cytosol|microtubule|mitotic spindle|centriolar subdistal appendage CEP170B 1594.998911 1588.711999 1601.285823 1.007914477 0.011373229 0.964791191 1 9.5717588 9.486076175 283638 centrosomal protein 170B "GO:0005737,GO:0005874" cytoplasm|microtubule CEP19 67.41428068 66.58648849 68.24207288 1.024863669 0.03543201 0.978581574 1 1.646709226 1.65941188 84984 centrosomal protein 19 "GO:0000922,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0005929,GO:0034454,GO:0036064,GO:0060271,GO:0097712" "spindle pole|protein binding|cytoplasm|centrosome|centriole|cilium|microtubule anchoring at centrosome|ciliary basal body|cilium assembly|vesicle targeting, trans-Golgi to periciliary membrane compartment" CEP192 1616.143727 1689.632145 1542.655309 0.913012524 -0.131293445 0.582155804 1 11.01546081 9.888959155 55125 centrosomal protein 192 "GO:0000086,GO:0000242,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0009617,GO:0010389,GO:0010923,GO:0019902,GO:0051298,GO:0071539,GO:0090222,GO:0090307,GO:0097711" G2/M transition of mitotic cell cycle|pericentriolar material|protein binding|centrosome|centriole|cytosol|response to bacterium|regulation of G2/M transition of mitotic cell cycle|negative regulation of phosphatase activity|phosphatase binding|centrosome duplication|protein localization to centrosome|centrosome-templated microtubule nucleation|mitotic spindle assembly|ciliary basal body-plasma membrane docking CEP20 853.9771214 819.8461395 888.1081033 1.08326192 0.115382112 0.646921616 1 18.73017194 19.95016167 123811 centrosomal protein 20 "GO:0005515,GO:0005654,GO:0005737,GO:0005813,GO:0005814,GO:0031514,GO:0034451,GO:0034453,GO:0036064,GO:0042802,GO:0060271" protein binding|nucleoplasm|cytoplasm|centrosome|centriole|motile cilium|centriolar satellite|microtubule anchoring|ciliary basal body|identical protein binding|cilium assembly CEP250 2010.714683 2245.213159 1776.216207 0.791112505 -0.338045218 0.153077588 1 10.8791447 8.462607166 11190 centrosomal protein 250 "GO:0000086,GO:0000278,GO:0001750,GO:0001917,GO:0005515,GO:0005813,GO:0005814,GO:0005815,GO:0005829,GO:0008022,GO:0008104,GO:0010389,GO:0010457,GO:0019901,GO:0019904,GO:0030997,GO:0032991,GO:0033365,GO:0036064,GO:0048471,GO:0050908,GO:0060271,GO:0070062,GO:0097711,GO:1904781,GO:1905515" G2/M transition of mitotic cell cycle|mitotic cell cycle|photoreceptor outer segment|photoreceptor inner segment|protein binding|centrosome|centriole|microtubule organizing center|cytosol|protein C-terminus binding|protein localization|regulation of G2/M transition of mitotic cell cycle|centriole-centriole cohesion|protein kinase binding|protein domain specific binding|regulation of centriole-centriole cohesion|protein-containing complex|protein localization to organelle|ciliary basal body|perinuclear region of cytoplasm|detection of light stimulus involved in visual perception|cilium assembly|extracellular exosome|ciliary basal body-plasma membrane docking|positive regulation of protein localization to centrosome|non-motile cilium assembly CEP290 768.682076 801.1186896 736.2454623 0.919021703 -0.121829164 0.632961787 1 4.493823005 4.060812238 80184 centrosomal protein 290 "GO:0000086,GO:0000930,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0010389,GO:0015031,GO:0016020,GO:0030902,GO:0030916,GO:0032391,GO:0032991,GO:0034451,GO:0035580,GO:0035869,GO:0036038,GO:0042462,GO:0042802,GO:0043312,GO:0045893,GO:0048793,GO:0051011,GO:0060271,GO:0070201,GO:0090316,GO:0097711" "G2/M transition of mitotic cell cycle|gamma-tubulin complex|protein binding|extracellular region|nucleus|cytoplasm|centrosome|centriole|cytosol|regulation of G2/M transition of mitotic cell cycle|protein transport|membrane|hindbrain development|otic vesicle formation|photoreceptor connecting cilium|protein-containing complex|centriolar satellite|specific granule lumen|ciliary transition zone|MKS complex|eye photoreceptor cell development|identical protein binding|neutrophil degranulation|positive regulation of transcription, DNA-templated|pronephros development|microtubule minus-end binding|cilium assembly|regulation of establishment of protein localization|positive regulation of intracellular protein transport|ciliary basal body-plasma membrane docking" CEP295 966.7280496 1079.94961 853.5064889 0.79032066 -0.339489972 0.168530052 1 6.231476466 4.842453655 85459 centrosomal protein 295 "GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0005856,GO:0005886,GO:0007099,GO:0008017,GO:0010825,GO:0046599,GO:1901985,GO:1903724,GO:1904951,GO:1990498" cytoplasm|centrosome|centriole|cytosol|cytoskeleton|plasma membrane|centriole replication|microtubule binding|positive regulation of centrosome duplication|regulation of centriole replication|positive regulation of protein acetylation|positive regulation of centriole elongation|positive regulation of establishment of protein localization|mitotic spindle microtubule CEP295NL 10.5676851 12.48496659 8.650403604 0.692865579 -0.529352609 0.69159681 1 0.309618829 0.210934457 100653515 CEP295 N-terminal like "GO:0005813,GO:0005814,GO:0005829,GO:0005929,GO:0008017,GO:0046599" centrosome|centriole|cytosol|cilium|microtubule binding|regulation of centriole replication CEP350 1557.547813 1703.157526 1411.938099 0.829012043 -0.270535036 0.256208861 1 6.637533729 5.410516912 9857 centrosomal protein 350 "GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005814,GO:0005819,GO:0008017,GO:0016020,GO:0034453,GO:0042995,GO:0071539,GO:1905515" protein binding|nucleus|cytoplasm|centrosome|centriole|spindle|microtubule binding|membrane|microtubule anchoring|cell projection|protein localization to centrosome|non-motile cilium assembly CEP41 819.3654462 844.8160727 793.9148197 0.939748716 -0.089653056 0.724388796 1 4.628981632 4.277286855 95681 centrosomal protein 41 "GO:0000086,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0005929,GO:0010389,GO:0015031,GO:0016020,GO:0018095,GO:0036064,GO:0060271,GO:0097711" G2/M transition of mitotic cell cycle|protein binding|centrosome|centriole|cytosol|cilium|regulation of G2/M transition of mitotic cell cycle|protein transport|membrane|protein polyglutamylation|ciliary basal body|cilium assembly|ciliary basal body-plasma membrane docking CEP43 416.7674755 431.7717613 401.7631896 0.930498994 -0.103923504 0.722536077 1 1.65110815 1.510645661 11116 centrosomal protein 43 "GO:0000086,GO:0005515,GO:0005634,GO:0005813,GO:0005814,GO:0005829,GO:0006469,GO:0008284,GO:0010389,GO:0019901,GO:0030292,GO:0030307,GO:0030335,GO:0034453,GO:0042803,GO:0042995,GO:0048471,GO:0061099,GO:0097711" G2/M transition of mitotic cell cycle|protein binding|nucleus|centrosome|centriole|cytosol|negative regulation of protein kinase activity|positive regulation of cell population proliferation|regulation of G2/M transition of mitotic cell cycle|protein kinase binding|protein tyrosine kinase inhibitor activity|positive regulation of cell growth|positive regulation of cell migration|microtubule anchoring|protein homodimerization activity|cell projection|perinuclear region of cytoplasm|negative regulation of protein tyrosine kinase activity|ciliary basal body-plasma membrane docking CEP44 448.0597642 395.3572754 500.7622531 1.2666069 0.340968844 0.224982935 1 2.626928679 3.271608367 80817 centrosomal protein 44 "GO:0000922,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0007098,GO:0007099,GO:0008017,GO:0010457,GO:0030496" spindle pole|protein binding|cytoplasm|centrosome|centriole|centrosome cycle|centriole replication|microtubule binding|centriole-centriole cohesion|midbody CEP55 7759.561027 8078.813799 7440.308255 0.920965434 -0.118781085 0.62956366 1 170.2137561 154.1378029 55165 centrosomal protein 55 "GO:0000281,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0005886,GO:0006997,GO:0007080,GO:0007275,GO:0014066,GO:0016020,GO:0030496,GO:0032154,GO:0034451,GO:0042802,GO:0045171,GO:0045184,GO:0061952,GO:0090543,GO:1904888" mitotic cytokinesis|protein binding|cytoplasm|centrosome|centriole|plasma membrane|nucleus organization|mitotic metaphase plate congression|multicellular organism development|regulation of phosphatidylinositol 3-kinase signaling|membrane|midbody|cleavage furrow|centriolar satellite|identical protein binding|intercellular bridge|establishment of protein localization|midbody abscission|Flemming body|cranial skeletal system development CEP57 1690.816368 1732.289115 1649.34362 0.952117985 -0.070787734 0.767568715 1 19.92007891 18.64889062 9702 centrosomal protein 57 "GO:0000086,GO:0005515,GO:0005634,GO:0005794,GO:0005813,GO:0005829,GO:0005874,GO:0007286,GO:0008017,GO:0008543,GO:0010389,GO:0017134,GO:0034453,GO:0042803,GO:0043015,GO:0051260,GO:0097711" G2/M transition of mitotic cell cycle|protein binding|nucleus|Golgi apparatus|centrosome|cytosol|microtubule|spermatid development|microtubule binding|fibroblast growth factor receptor signaling pathway|regulation of G2/M transition of mitotic cell cycle|fibroblast growth factor binding|microtubule anchoring|protein homodimerization activity|gamma-tubulin binding|protein homooligomerization|ciliary basal body-plasma membrane docking CEP57L1 428.034005 399.5189309 456.5490791 1.142747048 0.192506093 0.501236837 1 3.359847315 3.775207512 285753 centrosomal protein 57 like 1 "GO:0003674,GO:0005515,GO:0005575,GO:0005737,GO:0005813,GO:0005874,GO:0008017,GO:0008150,GO:0042802,GO:0043015" molecular_function|protein binding|cellular_component|cytoplasm|centrosome|microtubule|microtubule binding|biological_process|identical protein binding|gamma-tubulin binding CEP63 488.6308752 488.9945248 488.2672256 0.998512664 -0.00214737 1 1 7.177320973 7.046721771 80254 centrosomal protein 63 "GO:0000077,GO:0000086,GO:0000922,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0007099,GO:0010389,GO:0042770,GO:0051225,GO:0051301,GO:0097711,GO:0098535" DNA damage checkpoint|G2/M transition of mitotic cell cycle|spindle pole|protein binding|centrosome|centriole|cytosol|centriole replication|regulation of G2/M transition of mitotic cell cycle|signal transduction in response to DNA damage|spindle assembly|cell division|ciliary basal body-plasma membrane docking|de novo centriole assembly involved in multi-ciliated epithelial cell differentiation CEP68 502.5374541 563.9043244 441.1705838 0.782350063 -0.354113808 0.194603189 1 4.90378644 3.772279373 23177 centrosomal protein 68 "GO:0005515,GO:0005654,GO:0005813,GO:0005829,GO:0007098,GO:0010457,GO:0019901,GO:0019904,GO:0030054,GO:0033365,GO:0034451" protein binding|nucleoplasm|centrosome|cytosol|centrosome cycle|centriole-centriole cohesion|protein kinase binding|protein domain specific binding|cell junction|protein localization to organelle|centriolar satellite CEP70 572.5728912 585.7530159 559.3927664 0.954997672 -0.066430879 0.808067571 1 4.79162506 4.499417767 80321 centrosomal protein 70 "GO:0000086,GO:0005515,GO:0005813,GO:0005829,GO:0010389,GO:0042802,GO:0043015,GO:0070507,GO:0097711" G2/M transition of mitotic cell cycle|protein binding|centrosome|cytosol|regulation of G2/M transition of mitotic cell cycle|identical protein binding|gamma-tubulin binding|regulation of microtubule cytoskeleton organization|ciliary basal body-plasma membrane docking CEP72 299.2051227 285.0734038 313.3368417 1.099144422 0.136380961 0.672085887 1 5.576922148 6.027268251 55722 centrosomal protein 72 "GO:0000086,GO:0005515,GO:0005813,GO:0005829,GO:0007051,GO:0007099,GO:0010389,GO:0033566,GO:0034451,GO:0042802,GO:0097711,GO:1904779" G2/M transition of mitotic cell cycle|protein binding|centrosome|cytosol|spindle organization|centriole replication|regulation of G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|centriolar satellite|identical protein binding|ciliary basal body-plasma membrane docking|regulation of protein localization to centrosome CEP76 334.9408858 352.7003062 317.1814655 0.899294557 -0.153134359 0.620395278 1 4.815289616 4.257900967 79959 centrosomal protein 76 "GO:0000086,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0010389,GO:0032991,GO:0046599,GO:0097711" G2/M transition of mitotic cell cycle|protein binding|centrosome|centriole|cytosol|regulation of G2/M transition of mitotic cell cycle|protein-containing complex|regulation of centriole replication|ciliary basal body-plasma membrane docking CEP78 1212.599692 1239.132934 1186.06645 0.957174502 -0.063146129 0.796910667 1 5.671061424 5.337361898 84131 centrosomal protein 78 "GO:0000086,GO:0005813,GO:0005814,GO:0005829,GO:0010389,GO:0036064,GO:0044782,GO:0097711" G2/M transition of mitotic cell cycle|centrosome|centriole|cytosol|regulation of G2/M transition of mitotic cell cycle|ciliary basal body|cilium organization|ciliary basal body-plasma membrane docking CEP83 209.6496565 204.9615349 214.3377782 1.045746356 0.064532971 0.869595622 1 0.642718163 0.660873156 51134 centrosomal protein 83 "GO:0003674,GO:0005515,GO:0005794,GO:0005814,GO:0005829,GO:0048278,GO:0051660,GO:0060271,GO:0071539,GO:0097539,GO:0097711" molecular_function|protein binding|Golgi apparatus|centriole|cytosol|vesicle docking|establishment of centrosome localization|cilium assembly|protein localization to centrosome|ciliary transition fiber|ciliary basal body-plasma membrane docking CEP85 652.2293342 683.5519209 620.9067476 0.908353453 -0.138674316 0.595577513 1 7.89779383 7.053941317 64793 centrosomal protein 85 "GO:0000242,GO:0000922,GO:0005515,GO:0005730,GO:0005794,GO:0005813,GO:0005829,GO:0006469,GO:0007059,GO:0046602" pericentriolar material|spindle pole|protein binding|nucleolus|Golgi apparatus|centrosome|cytosol|negative regulation of protein kinase activity|chromosome segregation|regulation of mitotic centrosome separation CEP85L 195.4751214 198.7190516 192.2311912 0.967351593 -0.047887748 0.910406197 1 1.092200881 1.038862459 387119 centrosomal protein 85 like "GO:0005737,GO:0005813" cytoplasm|centrosome CEP89 380.6599604 392.2360338 369.0838871 0.940973943 -0.087773322 0.771983615 1 3.525840698 3.2622066 84902 centrosomal protein 89 "GO:0000922,GO:0005515,GO:0005758,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0007005,GO:0007268,GO:0031514,GO:0045202,GO:0060271,GO:0097539,GO:0097711,GO:0097730,GO:1905515" spindle pole|protein binding|mitochondrial intermembrane space|centrosome|centriole|cytosol|plasma membrane|mitochondrion organization|chemical synaptic transmission|motile cilium|synapse|cilium assembly|ciliary transition fiber|ciliary basal body-plasma membrane docking|non-motile cilium|non-motile cilium assembly CEP95 869.3399111 958.2211859 780.4586363 0.814486934 -0.296036539 0.235050659 1 8.405408211 6.731535036 90799 centrosomal protein 95 "GO:0000922,GO:0005515,GO:0005737,GO:0005813" spindle pole|protein binding|cytoplasm|centrosome CEP97 751.9656424 841.6948311 662.2364537 0.78678926 -0.34595083 0.172498441 1 5.362266463 4.148374855 79598 centrosomal protein 97 "GO:0005515,GO:0005516,GO:0005813,GO:0005829,GO:0032991,GO:0034451,GO:0097711,GO:1901673,GO:1902018" protein binding|calmodulin binding|centrosome|cytosol|protein-containing complex|centriolar satellite|ciliary basal body-plasma membrane docking|regulation of mitotic spindle assembly|negative regulation of cilium assembly CEPT1 467.0891546 478.590386 455.5879231 0.951937056 -0.071061912 0.804780337 1 9.548220295 8.937207514 10390 choline/ethanolamine phosphotransferase 1 "GO:0004142,GO:0004307,GO:0005515,GO:0005789,GO:0005794,GO:0006629,GO:0006646,GO:0006656,GO:0006657,GO:0016021,GO:0031965,GO:0046872" diacylglycerol cholinephosphotransferase activity|ethanolaminephosphotransferase activity|protein binding|endoplasmic reticulum membrane|Golgi apparatus|lipid metabolic process|phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process|CDP-choline pathway|integral component of membrane|nuclear membrane|metal ion binding "hsa00440,hsa00564,hsa00565" Phosphonate and phosphinate metabolism|Glycerophospholipid metabolism|Ether lipid metabolism CERCAM 1516.377851 1505.478888 1527.276814 1.014479064 0.020739093 0.933627035 1 14.10297372 14.06776045 51148 cerebral endothelial cell adhesion molecule "GO:0005515,GO:0005788,GO:0005886,GO:0007155,GO:0007159,GO:0018215,GO:0042802,GO:0050211" protein binding|endoplasmic reticulum lumen|plasma membrane|cell adhesion|leukocyte cell-cell adhesion|protein phosphopantetheinylation|identical protein binding|procollagen galactosyltransferase activity CERK 1263.189327 1217.284243 1309.094412 1.075422129 0.104903064 0.665604091 1 14.4750942 15.30634669 64781 ceramide kinase "GO:0000287,GO:0001727,GO:0001729,GO:0003951,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0006665,GO:0006672,GO:0006687,GO:0016021,GO:0016310,GO:0046834,GO:0102773" magnesium ion binding|lipid kinase activity|ceramide kinase activity|NAD+ kinase activity|protein binding|ATP binding|cytoplasm|plasma membrane|sphingolipid metabolic process|ceramide metabolic process|glycosphingolipid metabolic process|integral component of membrane|phosphorylation|lipid phosphorylation|dihydroceramide kinase activity hsa00600 Sphingolipid metabolism CERS1 22.26007242 16.64662212 27.87352272 1.674425149 0.743665885 0.375505823 1 0.183326378 0.301829632 10715 ceramide synthase 1 "GO:0005783,GO:0005789,GO:0016020,GO:0016021,GO:0016410,GO:0030148,GO:0035690,GO:0036146,GO:0043231,GO:0046513,GO:0050291,GO:0051974,GO:0071492,GO:0072721" endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane|N-acyltransferase activity|sphingolipid biosynthetic process|cellular response to drug|cellular response to mycotoxin|intracellular membrane-bounded organelle|ceramide biosynthetic process|sphingosine N-acyltransferase activity|negative regulation of telomerase activity|cellular response to UV-A|cellular response to dithiothreitol "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway CERS2 3933.248894 3979.583101 3886.914686 0.976714039 -0.03399186 0.887435695 1 81.43521317 78.20793997 29956 ceramide synthase 2 "GO:0003677,GO:0005515,GO:0005783,GO:0005789,GO:0016020,GO:0016021,GO:0016410,GO:0030148,GO:0046513,GO:0048681,GO:0050291,GO:1900148,GO:1905045" DNA binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane|N-acyltransferase activity|sphingolipid biosynthetic process|ceramide biosynthetic process|negative regulation of axon regeneration|sphingosine N-acyltransferase activity|negative regulation of Schwann cell migration|negative regulation of Schwann cell proliferation involved in axon regeneration "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway CERS4 239.3064826 251.7801596 226.8328056 0.900916125 -0.150535298 0.666052669 1 5.091718214 4.510450276 79603 ceramide synthase 4 "GO:0003677,GO:0005515,GO:0005783,GO:0005789,GO:0016021,GO:0016410,GO:0030148,GO:0046513,GO:0050291" DNA binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|N-acyltransferase activity|sphingolipid biosynthetic process|ceramide biosynthetic process|sphingosine N-acyltransferase activity "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway CERS5 1109.52449 1018.565191 1200.483789 1.178602803 0.237077602 0.33105591 1 15.32533189 17.76022799 91012 ceramide synthase 5 "GO:0003677,GO:0005783,GO:0005789,GO:0016021,GO:0016410,GO:0030148,GO:0046513,GO:0050291" DNA binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|N-acyltransferase activity|sphingolipid biosynthetic process|ceramide biosynthetic process|sphingosine N-acyltransferase activity "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway CERS6 1623.749915 1498.195991 1749.30384 1.167606809 0.223554529 0.347618278 1 7.703629104 8.844293833 253782 ceramide synthase 6 "GO:0003677,GO:0005515,GO:0005783,GO:0005789,GO:0006954,GO:0016020,GO:0016021,GO:0016410,GO:0030148,GO:0046513,GO:0050291" DNA binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|inflammatory response|membrane|integral component of membrane|N-acyltransferase activity|sphingolipid biosynthetic process|ceramide biosynthetic process|sphingosine N-acyltransferase activity "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway CERT1 1164.314181 1207.920518 1120.707845 0.927799328 -0.108115294 0.658089942 1 6.58002429 6.002784176 10087 ceramide transporter 1 "GO:0000902,GO:0001701,GO:0003007,GO:0005515,GO:0005654,GO:0005739,GO:0005789,GO:0005794,GO:0005829,GO:0006672,GO:0006936,GO:0006955,GO:0007029,GO:0007165,GO:0008283,GO:0016020,GO:0016301,GO:0016310,GO:0030148,GO:0034976,GO:0035621,GO:0035627,GO:0048471,GO:0055088,GO:0070273,GO:0070584,GO:0097001,GO:0120009,GO:0120012,GO:0120017,GO:1902387,GO:1902388,GO:1902389" cell morphogenesis|in utero embryonic development|heart morphogenesis|protein binding|nucleoplasm|mitochondrion|endoplasmic reticulum membrane|Golgi apparatus|cytosol|ceramide metabolic process|muscle contraction|immune response|endoplasmic reticulum organization|signal transduction|cell population proliferation|membrane|kinase activity|phosphorylation|sphingolipid biosynthetic process|response to endoplasmic reticulum stress|ER to Golgi ceramide transport|ceramide transport|perinuclear region of cytoplasm|lipid homeostasis|phosphatidylinositol-4-phosphate binding|mitochondrion morphogenesis|ceramide binding|intermembrane lipid transfer|intermembrane sphingolipid transfer|ceramide transfer activity|ceramide 1-phosphate binding|ceramide 1-phosphate transfer activity|ceramide 1-phosphate transport CES1 17.45932306 4.161655531 30.75699059 7.390566174 2.88568489 0.004084667 0.390726074 0.114131504 0.829381663 1066 carboxylesterase 1 "GO:0002003,GO:0004771,GO:0004806,GO:0005615,GO:0005737,GO:0005783,GO:0005788,GO:0005811,GO:0005829,GO:0006695,GO:0006805,GO:0008203,GO:0009636,GO:0010875,GO:0010887,GO:0016042,GO:0030855,GO:0042632,GO:0043691,GO:0047374,GO:0051791,GO:0052689,GO:0070857,GO:0071397,GO:0071404,GO:0080030,GO:0090122,GO:0090205,GO:0120188" angiotensin maturation|sterol esterase activity|triglyceride lipase activity|extracellular space|cytoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|lipid droplet|cytosol|cholesterol biosynthetic process|xenobiotic metabolic process|cholesterol metabolic process|response to toxic substance|positive regulation of cholesterol efflux|negative regulation of cholesterol storage|lipid catabolic process|epithelial cell differentiation|cholesterol homeostasis|reverse cholesterol transport|methylumbelliferyl-acetate deacetylase activity|medium-chain fatty acid metabolic process|carboxylic ester hydrolase activity|regulation of bile acid biosynthetic process|cellular response to cholesterol|cellular response to low-density lipoprotein particle stimulus|methyl indole-3-acetate esterase activity|cholesterol ester hydrolysis involved in cholesterol transport|positive regulation of cholesterol metabolic process|regulation of bile acid secretion hsa00983 Drug metabolism - other enzymes CES2 855.2056193 852.0989699 858.3122687 1.007291757 0.010481614 0.971745413 1 11.75671043 11.64427035 8824 carboxylesterase 2 "GO:0004771,GO:0004806,GO:0005615,GO:0005783,GO:0005788,GO:0006693,GO:0006805,GO:0009056,GO:0016042,GO:0047374,GO:0052689,GO:0080030" sterol esterase activity|triglyceride lipase activity|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|prostaglandin metabolic process|xenobiotic metabolic process|catabolic process|lipid catabolic process|methylumbelliferyl-acetate deacetylase activity|carboxylic ester hydrolase activity|methyl indole-3-acetate esterase activity hsa00983 Drug metabolism - other enzymes CES3 20.93722538 19.76786377 22.10658699 1.118309355 0.161319333 0.905077037 1 0.246316731 0.270848883 23491 carboxylesterase 3 "GO:0004771,GO:0004806,GO:0005615,GO:0005788,GO:0005829,GO:0006805,GO:0016042,GO:0034383,GO:0052689,GO:0070062,GO:0080030" sterol esterase activity|triglyceride lipase activity|extracellular space|endoplasmic reticulum lumen|cytosol|xenobiotic metabolic process|lipid catabolic process|low-density lipoprotein particle clearance|carboxylic ester hydrolase activity|extracellular exosome|methyl indole-3-acetate esterase activity CES4A 16.81519881 12.48496659 21.14543103 1.693671415 0.760154008 0.42578865 1 0.164803295 0.27445189 283848 carboxylesterase 4A "GO:0004771,GO:0004806,GO:0005615,GO:0016042,GO:0052689" sterol esterase activity|triglyceride lipase activity|extracellular space|lipid catabolic process|carboxylic ester hydrolase activity CETN2 1490.463696 1115.323682 1865.603711 1.672701603 0.742180102 0.00195113 0.275095265 42.12510619 69.28363422 1069 centrin 2 "GO:0000086,GO:0000278,GO:0000715,GO:0000717,GO:0005509,GO:0005515,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0006289,GO:0006294,GO:0007099,GO:0007283,GO:0008017,GO:0010389,GO:0015031,GO:0031683,GO:0032391,GO:0032465,GO:0032795,GO:0036064,GO:0044615,GO:0045177,GO:0051028,GO:0051301,GO:0070390,GO:0070911,GO:0071942,GO:0097711,GO:0097729" "G2/M transition of mitotic cell cycle|mitotic cell cycle|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|calcium ion binding|protein binding|nucleoplasm|centrosome|centriole|cytosol|nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|centriole replication|spermatogenesis|microtubule binding|regulation of G2/M transition of mitotic cell cycle|protein transport|G-protein beta/gamma-subunit complex binding|photoreceptor connecting cilium|regulation of cytokinesis|heterotrimeric G-protein binding|ciliary basal body|nuclear pore nuclear basket|apical part of cell|mRNA transport|cell division|transcription export complex 2|global genome nucleotide-excision repair|XPC complex|ciliary basal body-plasma membrane docking|9+2 motile cilium" hsa03420 Nucleotide excision repair CETN3 644.5708835 507.7219747 781.4197922 1.539070261 0.622059095 0.016693052 0.768611058 10.93470082 16.54765776 1070 centrin 3 "GO:0005509,GO:0005515,GO:0005730,GO:0005737,GO:0005813,GO:0005814,GO:0005815,GO:0007098,GO:0008017,GO:0015031,GO:0044615,GO:0051028,GO:0051301,GO:0070390" calcium ion binding|protein binding|nucleolus|cytoplasm|centrosome|centriole|microtubule organizing center|centrosome cycle|microtubule binding|protein transport|nuclear pore nuclear basket|mRNA transport|cell division|transcription export complex 2 CFAP20 930.4682779 821.9269673 1039.009588 1.264114246 0.338126855 0.171988026 1 34.24256956 42.56217871 29105 cilia and flagella associated protein 20 "GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0005814,GO:0005874,GO:0005929,GO:0007275,GO:0018095,GO:0031514,GO:0036064,GO:0060271,GO:0060296,GO:0070062,GO:2000147,GO:2000253" RNA binding|protein binding|nucleoplasm|cytoplasm|centriole|microtubule|cilium|multicellular organism development|protein polyglutamylation|motile cilium|ciliary basal body|cilium assembly|regulation of cilium beat frequency involved in ciliary motility|extracellular exosome|positive regulation of cell motility|positive regulation of feeding behavior CFAP206 12.33148116 8.323311061 16.33965125 1.96311914 0.973147731 0.371650685 1 0.201268606 0.388502551 154313 cilia and flagella associated protein 206 "GO:0001534,GO:0003341,GO:0003356,GO:0005515,GO:0005930,GO:0007288,GO:0031514,GO:0035082,GO:0036064,GO:0097649,GO:1901317" radial spoke|cilium movement|regulation of cilium beat frequency|protein binding|axoneme|sperm axoneme assembly|motile cilium|axoneme assembly|ciliary basal body|A axonemal microtubule|regulation of flagellated sperm motility CFAP20DC 841.5179213 631.5312268 1051.504616 1.665008112 0.735529207 0.003371347 0.373212871 5.317712349 8.705873929 200844 CFAP20 domain containing CFAP251 763.5699397 666.9052988 860.2345806 1.289890157 0.367248216 0.14687552 1 8.366598513 10.61140368 144406 cilia and flagella associated protein 251 "GO:0001536,GO:0003341,GO:0005930,GO:0030317,GO:0031514,GO:0036126" radial spoke stalk|cilium movement|axoneme|flagellated sperm motility|motile cilium|sperm flagellum CFAP298 146.6895254 116.5263549 176.8526959 1.517705554 0.601891924 0.141634921 1 1.349858344 2.014405495 56683 cilia and flagella associated protein 298 "GO:0003352,GO:0005515,GO:0005634,GO:0005829,GO:0005856,GO:0005929,GO:0060271" regulation of cilium movement|protein binding|nucleus|cytosol|cytoskeleton|cilium|cilium assembly CFAP299 10.52805613 11.44455271 9.61155956 0.839837065 -0.251818634 0.906931683 1 0.104405939 0.086216705 255119 cilia and flagella associated protein 299 "GO:0005515,GO:0005634,GO:0005737" protein binding|nucleus|cytoplasm CFAP300 87.59352534 79.07145508 96.1155956 1.215553647 0.281613566 0.57772433 1 3.365150104 4.022071161 85016 cilia and flagella associated protein 300 "GO:0005515,GO:0005737,GO:0005856,GO:0031514" protein binding|cytoplasm|cytoskeleton|motile cilium CFAP36 582.2096028 523.328183 641.0910226 1.225026749 0.292813251 0.268939037 1 11.19401334 13.48349786 112942 cilia and flagella associated protein 36 "GO:0005515,GO:0005634,GO:0005930,GO:0008150,GO:0031514,GO:0035869,GO:0047485,GO:0097546" protein binding|nucleus|axoneme|biological_process|motile cilium|ciliary transition zone|protein N-terminus binding|ciliary base CFAP410 90.08070357 68.66731625 111.4940909 1.623684993 0.699271766 0.150612933 1 1.375618793 2.196195794 755 cilia and flagella associated protein 410 "GO:0001750,GO:0003674,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0007010,GO:0008360,GO:0032391,GO:0036064,GO:0042769,GO:0043231,GO:0060271" "photoreceptor outer segment|molecular_function|protein binding|cytoplasm|mitochondrion|cytosol|plasma membrane|cytoskeleton organization|regulation of cell shape|photoreceptor connecting cilium|ciliary basal body|DNA damage response, detection of DNA damage|intracellular membrane-bounded organelle|cilium assembly" CFAP43 41.23032651 47.8590386 34.60161442 0.722990169 -0.467952065 0.480135635 1 0.458307721 0.32580725 80217 cilia and flagella associated protein 43 "GO:0003356,GO:0005576,GO:0005930,GO:0007288,GO:0007420,GO:0044458,GO:0060271,GO:0090660,GO:0097729,GO:0120197" regulation of cilium beat frequency|extracellular region|axoneme|sperm axoneme assembly|brain development|motile cilium assembly|cilium assembly|cerebrospinal fluid circulation|9+2 motile cilium|mucociliary clearance CFAP44 100.3458338 136.2942186 64.39744905 0.472488486 -1.081648921 0.020998323 0.821508434 0.690176672 0.32064368 55779 cilia and flagella associated protein 44 "GO:0000226,GO:0005515,GO:0005737,GO:0005856,GO:0006508,GO:0007288,GO:0008233,GO:0031514,GO:0060271,GO:0060285" microtubule cytoskeleton organization|protein binding|cytoplasm|cytoskeleton|proteolysis|sperm axoneme assembly|peptidase activity|motile cilium|cilium assembly|cilium-dependent cell motility CFAP45 17.57317953 19.76786377 15.3784953 0.777954334 -0.362242623 0.732472871 1 0.572112016 0.437629261 25790 cilia and flagella associated protein 45 "GO:0005515,GO:0005634,GO:0005654,GO:0005929" protein binding|nucleus|nucleoplasm|cilium CFAP52 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.079095408 0 146845 cilia and flagella associated protein 52 "GO:0005515,GO:0005737,GO:0031514,GO:0060271" protein binding|cytoplasm|motile cilium|cilium assembly CFAP53 31.06396146 33.29324424 28.83467868 0.866081974 -0.207424514 0.810722965 1 0.930748693 0.792615595 220136 cilia and flagella associated protein 53 "GO:0003341,GO:0005515,GO:0005575,GO:0005576,GO:0005929,GO:0007368,GO:0060271,GO:0060287" cilium movement|protein binding|cellular_component|extracellular region|cilium|determination of left/right symmetry|cilium assembly|epithelial cilium movement involved in determination of left/right asymmetry CFAP54 33.0655313 35.37407201 30.75699059 0.869478373 -0.201777951 0.810082932 1 0.189333989 0.161867086 144535 cilia and flagella associated protein 54 "GO:0005930,GO:0007283,GO:0030154,GO:0060271,GO:0060294" axoneme|spermatogenesis|cell differentiation|cilium assembly|cilium movement involved in cell motility CFAP57 13.33226608 9.363724944 17.30080721 1.847641543 0.88568489 0.401500149 1 0.10372038 0.188431279 149465 cilia and flagella associated protein 57 CFAP58 46.83874639 43.69738307 49.98010971 1.143778098 0.193807185 0.781181778 1 0.716231272 0.805501278 159686 cilia and flagella associated protein 58 "GO:0005515,GO:0005615,GO:0005856,GO:0005929" protein binding|extracellular space|cytoskeleton|cilium CFAP69 122.7795134 119.6475965 125.9114302 1.052352357 0.073617841 0.884386021 1 1.013712069 1.048931129 79846 cilia and flagella associated protein 69 "GO:0005737,GO:0007288,GO:0007608,GO:0030317,GO:0042048,GO:0097225,GO:0097730,GO:1902093,GO:1905516,GO:1990834" cytoplasm|sperm axoneme assembly|sensory perception of smell|flagellated sperm motility|olfactory behavior|sperm midpiece|non-motile cilium|positive regulation of flagellated sperm motility|positive regulation of fertilization|response to odorant CFAP70 36.10751502 39.53572754 32.6793025 0.82657648 -0.274779782 0.713419355 1 0.3306612 0.268743184 118491 cilia and flagella associated protein 70 "GO:0003341,GO:0003674,GO:0005930,GO:0008150,GO:0036064,GO:0036126,GO:0036157,GO:0060271,GO:0070062" cilium movement|molecular_function|axoneme|biological_process|ciliary basal body|sperm flagellum|outer dynein arm|cilium assembly|extracellular exosome CFAP73 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.061763044 0.07480426 387885 cilia and flagella associated protein 73 "GO:0003341,GO:0031514,GO:0036159,GO:0070840,GO:0097545,GO:2000574" cilium movement|motile cilium|inner dynein arm assembly|dynein complex binding|axonemal outer doublet|regulation of microtubule motor activity CFAP91 34.14557415 38.49531366 29.79583464 0.774011998 -0.369572165 0.615910403 1 0.463438786 0.352704702 89876 cilia and flagella associated protein 91 "GO:0001536,GO:0003341,GO:0005515,GO:0005739,GO:0005930,GO:0031514" radial spoke stalk|cilium movement|protein binding|mitochondrion|axoneme|motile cilium CFAP97 1253.532494 1329.648942 1177.416046 0.885508956 -0.175421197 0.468186598 1 9.340650289 8.132821659 57587 cilia and flagella associated protein 97 CFB 485.895248 619.0462602 352.7442358 0.569818863 -0.811424715 0.003254661 0.367925679 13.34303762 7.475886695 629 complement factor B "GO:0001848,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0006508,GO:0006956,GO:0006957,GO:0030449,GO:0070062,GO:0072562" "complement binding|serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|plasma membrane|proteolysis|complement activation|complement activation, alternative pathway|regulation of complement activation|extracellular exosome|blood microparticle" "hsa04610,hsa05150,hsa05171" Complement and coagulation cascades|Staphylococcus aureus infection|Coronavirus disease - COVID-19 CFD 58.48647434 59.30359131 57.66935736 0.972442918 -0.040314528 0.976962679 1 2.657366644 2.540895333 1675 complement factor D "GO:0002576,GO:0004252,GO:0005576,GO:0006508,GO:0006956,GO:0006957,GO:0007219,GO:0008236,GO:0031093,GO:0034774,GO:0043312,GO:0070062,GO:1904813" "platelet degranulation|serine-type endopeptidase activity|extracellular region|proteolysis|complement activation|complement activation, alternative pathway|Notch signaling pathway|serine-type peptidase activity|platelet alpha granule lumen|secretory granule lumen|neutrophil degranulation|extracellular exosome|ficolin-1-rich granule lumen" "hsa04610,hsa05150,hsa05171" Complement and coagulation cascades|Staphylococcus aureus infection|Coronavirus disease - COVID-19 CFDP1 809.5412649 776.1487565 842.9337734 1.086046671 0.119086102 0.638492078 1 23.4949703 25.08964796 10428 craniofacial development protein 1 "GO:0000777,GO:0003674,GO:0005575,GO:0007155,GO:0007275,GO:0008150,GO:0008360,GO:0042127,GO:2000270" condensed chromosome kinetochore|molecular_function|cellular_component|cell adhesion|multicellular organism development|biological_process|regulation of cell shape|regulation of cell population proliferation|negative regulation of fibroblast apoptotic process CFH 177.8428056 126.9304937 228.7551175 1.802207735 0.849765316 0.025776972 0.86539048 1.597275916 2.830453153 3075 complement factor H "GO:0005515,GO:0005576,GO:0005615,GO:0006956,GO:0006957,GO:0008201,GO:0016032,GO:0030449,GO:0042802,GO:0043395,GO:0070062,GO:0072562,GO:1903659" "protein binding|extracellular region|extracellular space|complement activation|complement activation, alternative pathway|heparin binding|viral process|regulation of complement activation|identical protein binding|heparan sulfate proteoglycan binding|extracellular exosome|blood microparticle|regulation of complement-dependent cytotoxicity" "hsa04610,hsa05150" Complement and coagulation cascades|Staphylococcus aureus infection CFHR1 5.885822626 3.121241648 8.650403604 2.771462315 1.470647391 0.36367629 1 0.128430941 0.349985313 3078 complement factor H related 1 "GO:0005515,GO:0005576,GO:0005615,GO:0006956,GO:0030449,GO:0032091,GO:0032991,GO:0042802,GO:0051838,GO:0072562" protein binding|extracellular region|extracellular space|complement activation|regulation of complement activation|negative regulation of protein binding|protein-containing complex|identical protein binding|cytolysis by host of symbiont cells|blood microparticle hsa04610 Complement and coagulation cascades CFHR3 18.9752845 18.72744989 19.22311912 1.026467524 0.037687984 1 1 0.340644029 0.343808946 10878 complement factor H related 3 "GO:0005515,GO:0005615,GO:0070062,GO:0072562" protein binding|extracellular space|extracellular exosome|blood microparticle hsa04610 Complement and coagulation cascades CFI 4.885037707 2.080827765 7.689247648 3.695283087 1.88568489 0.299624042 1 0.040588433 0.147475943 3426 complement factor I "GO:0004252,GO:0005044,GO:0005515,GO:0005576,GO:0005615,GO:0006508,GO:0006897,GO:0006958,GO:0016020,GO:0016032,GO:0030449,GO:0045087,GO:0046872,GO:0070062" "serine-type endopeptidase activity|scavenger receptor activity|protein binding|extracellular region|extracellular space|proteolysis|endocytosis|complement activation, classical pathway|membrane|viral process|regulation of complement activation|innate immune response|metal ion binding|extracellular exosome" "hsa04610,hsa05150" Complement and coagulation cascades|Staphylococcus aureus infection CFL1 17025.80863 14481.52083 19570.09642 1.35138406 0.434437743 0.10413041 1 620.7647799 824.8539133 1072 cofilin 1 "GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005925,GO:0007010,GO:0007266,GO:0009615,GO:0015629,GO:0016020,GO:0016032,GO:0016363,GO:0022604,GO:0030027,GO:0030036,GO:0030042,GO:0030043,GO:0031258,GO:0031982,GO:0032587,GO:0035722,GO:0040019,GO:0043066,GO:0044794,GO:0048870,GO:0051014,GO:0051015,GO:0051293,GO:0061001,GO:0070062" protein binding|extracellular space|nucleus|cytoplasm|cytosol|focal adhesion|cytoskeleton organization|Rho protein signal transduction|response to virus|actin cytoskeleton|membrane|viral process|nuclear matrix|regulation of cell morphogenesis|lamellipodium|actin cytoskeleton organization|actin filament depolymerization|actin filament fragmentation|lamellipodium membrane|vesicle|ruffle membrane|interleukin-12-mediated signaling pathway|positive regulation of embryonic development|negative regulation of apoptotic process|positive regulation by host of viral process|cell motility|actin filament severing|actin filament binding|establishment of spindle localization|regulation of dendritic spine morphogenesis|extracellular exosome "hsa04360,hsa04666,hsa04810,hsa05133,hsa05170" Axon guidance|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Pertussis|Human immunodeficiency virus 1 infection CFL2 2490.167344 2354.456616 2625.878072 1.115279871 0.157405789 0.505991095 1 27.48316324 30.13850877 1073 cofilin 2 "GO:0005515,GO:0005615,GO:0005737,GO:0007519,GO:0015629,GO:0016363,GO:0030018,GO:0030042,GO:0030043,GO:0030836,GO:0031674,GO:0045214,GO:0046716,GO:0048870,GO:0051014,GO:0051015,GO:0070062" protein binding|extracellular space|cytoplasm|skeletal muscle tissue development|actin cytoskeleton|nuclear matrix|Z disc|actin filament depolymerization|actin filament fragmentation|positive regulation of actin filament depolymerization|I band|sarcomere organization|muscle cell cellular homeostasis|cell motility|actin filament severing|actin filament binding|extracellular exosome "hsa04360,hsa04666,hsa04810,hsa05133,hsa05170" Axon guidance|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Pertussis|Human immunodeficiency virus 1 infection CFLAR 2101.327497 1987.190516 2215.464479 1.114872711 0.156879002 0.507741097 1 5.589369955 6.127161394 8837 CASP8 and FADD like apoptosis regulator "GO:0002020,GO:0005123,GO:0005515,GO:0005737,GO:0005829,GO:0006508,GO:0006915,GO:0006919,GO:0007519,GO:0008047,GO:0010667,GO:0010976,GO:0014732,GO:0014842,GO:0014866,GO:0016032,GO:0031264,GO:0031265,GO:0032869,GO:0033574,GO:0042060,GO:0043066,GO:0043123,GO:0043403,GO:0044877,GO:0045121,GO:0051092,GO:0060544,GO:0070374,GO:0071364,GO:0071392,GO:0071456,GO:0071549,GO:0071732,GO:0072126,GO:0097153,GO:0097190,GO:0097194,GO:0097199,GO:0097200,GO:0097342,GO:1901740,GO:1902041,GO:1902042,GO:1903055,GO:1903427,GO:1903845,GO:1903944,GO:2000347,GO:2001237" protease binding|death receptor binding|protein binding|cytoplasm|cytosol|proteolysis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|skeletal muscle tissue development|enzyme activator activity|negative regulation of cardiac muscle cell apoptotic process|positive regulation of neuron projection development|skeletal muscle atrophy|regulation of skeletal muscle satellite cell proliferation|skeletal myofibril assembly|viral process|death-inducing signaling complex|CD95 death-inducing signaling complex|cellular response to insulin stimulus|response to testosterone|wound healing|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|skeletal muscle tissue regeneration|protein-containing complex binding|membrane raft|positive regulation of NF-kappaB transcription factor activity|regulation of necroptotic process|positive regulation of ERK1 and ERK2 cascade|cellular response to epidermal growth factor stimulus|cellular response to estradiol stimulus|cellular response to hypoxia|cellular response to dexamethasone stimulus|cellular response to nitric oxide|positive regulation of glomerular mesangial cell proliferation|cysteine-type endopeptidase activity involved in apoptotic process|apoptotic signaling pathway|execution phase of apoptosis|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|cysteine-type endopeptidase activity involved in execution phase of apoptosis|ripoptosome|negative regulation of myoblast fusion|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of extracellular matrix organization|negative regulation of reactive oxygen species biosynthetic process|negative regulation of cellular response to transforming growth factor beta stimulus|negative regulation of hepatocyte apoptotic process|positive regulation of hepatocyte proliferation|negative regulation of extrinsic apoptotic signaling pathway "hsa04064,hsa04140,hsa04210,hsa04217,hsa04668,hsa05142,hsa05160" NF-kappa B signaling pathway|Autophagy - animal|Apoptosis|Necroptosis|TNF signaling pathway|Chagas disease|Hepatitis C CFP 5.965080553 5.202069413 6.728091692 1.29334908 0.371111717 0.919461532 1 0.076691957 0.09752967 5199 complement factor properdin "GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0006955,GO:0006956,GO:0006957,GO:0030449,GO:0035580,GO:0042742,GO:0043312,GO:0062023,GO:1904724" "protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|immune response|complement activation|complement activation, alternative pathway|regulation of complement activation|specific granule lumen|defense response to bacterium|neutrophil degranulation|collagen-containing extracellular matrix|tertiary granule lumen" hsa05168 Herpes simplex virus 1 infection CGAS 416.7228161 443.216314 390.2293181 0.880448905 -0.183688813 0.524255446 1 7.389453321 6.397166379 115004 cyclic GMP-AMP synthase "GO:0002218,GO:0002230,GO:0002637,GO:0003677,GO:0003682,GO:0003690,GO:0005515,GO:0005524,GO:0005525,GO:0005546,GO:0005634,GO:0005829,GO:0005886,GO:0006281,GO:0006974,GO:0008340,GO:0010753,GO:0016032,GO:0032481,GO:0035861,GO:0038001,GO:0043950,GO:0045087,GO:0046872,GO:0050863,GO:0051607,GO:0061501,GO:0071360,GO:2000042,GO:2000774" "activation of innate immune response|positive regulation of defense response to virus by host|regulation of immunoglobulin production|DNA binding|chromatin binding|double-stranded DNA binding|protein binding|ATP binding|GTP binding|phosphatidylinositol-4,5-bisphosphate binding|nucleus|cytosol|plasma membrane|DNA repair|cellular response to DNA damage stimulus|determination of adult lifespan|positive regulation of cGMP-mediated signaling|viral process|positive regulation of type I interferon production|site of double-strand break|paracrine signaling|positive regulation of cAMP-mediated signaling|innate immune response|metal ion binding|regulation of T cell activation|defense response to virus|cyclic-GMP-AMP synthase activity|cellular response to exogenous dsRNA|negative regulation of double-strand break repair via homologous recombination|positive regulation of cellular senescence" "hsa04623,hsa05131,hsa05163,hsa05168,hsa05170,hsa05171" Cytosolic DNA-sensing pathway|Shigellosis|Human cytomegalovirus infection|Herpes simplex virus 1 infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19 CGB7 9.928591267 8.323311061 11.53387147 1.385731158 0.470647391 0.750315201 1 0.206508514 0.281376694 94027 chorionic gonadotropin subunit beta 7 "GO:0005179,GO:0005615,GO:0005737,GO:0006915,GO:0007165,GO:0007186,GO:0007267,GO:0007292,GO:0009755" hormone activity|extracellular space|cytoplasm|apoptotic process|signal transduction|G protein-coupled receptor signaling pathway|cell-cell signaling|female gamete generation|hormone-mediated signaling pathway CGB8 9.368755362 6.242483296 12.49502743 2.001611672 1.001162108 0.427900976 1 0.375591725 0.739208614 94115 chorionic gonadotropin subunit beta 8 CGGBP1 3332.441403 3296.03118 3368.851626 1.022093373 0.031526999 0.895446538 1 36.93891773 37.12324383 8545 CGG triplet repeat binding protein 1 "GO:0000122,GO:0003690,GO:0005515,GO:0005634,GO:0005654,GO:0010468,GO:0042802,GO:0090579" negative regulation of transcription by RNA polymerase II|double-stranded DNA binding|protein binding|nucleus|nucleoplasm|regulation of gene expression|identical protein binding|dsDNA loop formation CGN 125.3704872 149.8195991 100.9213754 0.673619313 -0.569994594 0.187770774 1 1.524713319 1.009889607 57530 cingulin "GO:0003774,GO:0003779,GO:0005515,GO:0005886,GO:0005923,GO:0007179,GO:0008150,GO:0016459,GO:0030054,GO:0045296" motor activity|actin binding|protein binding|plasma membrane|bicellular tight junction|transforming growth factor beta receptor signaling pathway|biological_process|myosin complex|cell junction|cadherin binding hsa04530 Tight junction CGNL1 88.83208404 86.35435226 91.30981582 1.057385221 0.080501067 0.892096096 1 0.522454718 0.543191631 84952 cingulin like 1 "GO:0003774,GO:0005515,GO:0005923,GO:0007015,GO:0016459,GO:0032991,GO:0051058,GO:0051497,GO:0150105" motor activity|protein binding|bicellular tight junction|actin filament organization|myosin complex|protein-containing complex|negative regulation of small GTPase mediated signal transduction|negative regulation of stress fiber assembly|protein localization to cell-cell junction hsa04530 Tight junction CGREF1 10.00784919 10.40413883 9.61155956 0.923820772 -0.11431511 1 1 0.205724256 0.186872072 10669 cell growth regulator with EF-hand domain 1 "GO:0005509,GO:0005576,GO:0007050,GO:0007155,GO:0008285" calcium ion binding|extracellular region|cell cycle arrest|cell adhesion|negative regulation of cell population proliferation CGRRF1 232.791627 219.5273292 246.0559247 1.120844159 0.164585701 0.639645438 1 5.263149186 5.800455402 10668 cell growth regulator with ring finger domain 1 "GO:0005515,GO:0005654,GO:0005783,GO:0007050,GO:0008285,GO:0030308,GO:0043231,GO:0046872" protein binding|nucleoplasm|endoplasmic reticulum|cell cycle arrest|negative regulation of cell population proliferation|negative regulation of cell growth|intracellular membrane-bounded organelle|metal ion binding CH25H 3.081612685 5.202069413 0.961155956 0.184764154 -2.436243205 0.338470402 1 0.164372341 0.029861914 9023 cholesterol 25-hydroxylase "GO:0000254,GO:0001567,GO:0005506,GO:0005515,GO:0005789,GO:0005829,GO:0006629,GO:0006699,GO:0008203,GO:0008395,GO:0016020,GO:0016021,GO:0016126,GO:0016491,GO:0035754,GO:0055114" C-4 methylsterol oxidase activity|cholesterol 25-hydroxylase activity|iron ion binding|protein binding|endoplasmic reticulum membrane|cytosol|lipid metabolic process|bile acid biosynthetic process|cholesterol metabolic process|steroid hydroxylase activity|membrane|integral component of membrane|sterol biosynthetic process|oxidoreductase activity|B cell chemotaxis|oxidation-reduction process hsa00120 Primary bile acid biosynthesis CHAC1 120.7232233 153.9812546 87.465192 0.568024934 -0.815973835 0.062442425 1 2.207871186 1.233139786 79094 ChaC glutathione specific gamma-glutamylcyclotransferase 1 "GO:0003839,GO:0005112,GO:0005515,GO:0005737,GO:0005802,GO:0005829,GO:0006750,GO:0006751,GO:0006986,GO:0007219,GO:0010955,GO:0022008,GO:0045746,GO:0061928,GO:0070059" gamma-glutamylcyclotransferase activity|Notch binding|protein binding|cytoplasm|trans-Golgi network|cytosol|glutathione biosynthetic process|glutathione catabolic process|response to unfolded protein|Notch signaling pathway|negative regulation of protein processing|neurogenesis|negative regulation of Notch signaling pathway|glutathione specific gamma-glutamylcyclotransferase activity|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress hsa00480 Glutathione metabolism CHAC2 86.70659689 93.63724944 79.77594435 0.851968045 -0.231128775 0.652931937 1 3.757329252 3.147557974 494143 ChaC glutathione specific gamma-glutamylcyclotransferase 2 "GO:0003674,GO:0003839,GO:0005575,GO:0005737,GO:0005829,GO:0006750,GO:0006751,GO:0008150,GO:0061928" molecular_function|gamma-glutamylcyclotransferase activity|cellular_component|cytoplasm|cytosol|glutathione biosynthetic process|glutathione catabolic process|biological_process|glutathione specific gamma-glutamylcyclotransferase activity hsa00480 Glutathione metabolism CHADL 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.021920638 0.079647489 150356 chondroadherin like "GO:0005518,GO:0005615,GO:0030021,GO:0031012,GO:0032331,GO:0062023,GO:0098633,GO:1904027" collagen binding|extracellular space|extracellular matrix structural constituent conferring compression resistance|extracellular matrix|negative regulation of chondrocyte differentiation|collagen-containing extracellular matrix|collagen fibril binding|negative regulation of collagen fibril organization CHAF1A 897.4317003 913.483389 881.3800116 0.964856091 -0.051614316 0.839482743 1 11.27710607 10.69870929 10036 chromatin assembly factor 1 subunit A "GO:0000785,GO:0003682,GO:0005515,GO:0005634,GO:0006260,GO:0006281,GO:0006334,GO:0006335,GO:0007049,GO:0031497,GO:0032991,GO:0033186,GO:0042802,GO:0051082,GO:0070087" chromatin|chromatin binding|protein binding|nucleus|DNA replication|DNA repair|nucleosome assembly|DNA replication-dependent nucleosome assembly|cell cycle|chromatin assembly|protein-containing complex|CAF-1 complex|identical protein binding|unfolded protein binding|chromo shadow domain binding CHAF1B 771.1994367 715.8047513 826.5941222 1.154775965 0.207612985 0.412825772 1 6.359444645 7.220846384 8208 chromatin assembly factor 1 subunit B "GO:0000785,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006260,GO:0006281,GO:0006334,GO:0006335,GO:0007049,GO:0031497,GO:0032991,GO:0033186,GO:0042393,GO:0051082" chromatin|chromatin binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA replication|DNA repair|nucleosome assembly|DNA replication-dependent nucleosome assembly|cell cycle|chromatin assembly|protein-containing complex|CAF-1 complex|histone binding|unfolded protein binding CHAMP1 709.1054979 763.6637899 654.547206 0.857114367 -0.222440375 0.385485315 1 10.72791074 9.041179778 283489 chromosome alignment maintaining phosphoprotein 1 "GO:0000777,GO:0000793,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005819,GO:0016604,GO:0031134,GO:0034501,GO:0035372,GO:0046872,GO:0051315,GO:0090543" condensed chromosome kinetochore|condensed chromosome|protein binding|nucleus|nucleoplasm|cytoplasm|spindle|nuclear body|sister chromatid biorientation|protein localization to kinetochore|protein localization to microtubule|metal ion binding|attachment of mitotic spindle microtubules to kinetochore|Flemming body CHCHD1 488.5270796 448.4183834 528.6357758 1.178889616 0.237428639 0.389415907 1 28.15442937 32.63555859 118487 coiled-coil-helix-coiled-coil-helix domain containing 1 "GO:0001650,GO:0003723,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005761,GO:0005829,GO:0070125,GO:0070126" fibrillar center|RNA binding|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|cytosol|mitochondrial translational elongation|mitochondrial translational termination CHCHD10 483.3596087 451.5396251 515.1795924 1.140939939 0.190222848 0.492835253 1 33.42280152 37.49529818 400916 coiled-coil-helix-coiled-coil-helix domain containing 10 "GO:0003674,GO:0005515,GO:0005634,GO:0005739,GO:0005758,GO:0006119,GO:0007005,GO:0030322,GO:0051457,GO:0061617,GO:0065003,GO:0090144,GO:0099558,GO:1901030,GO:1903109,GO:1903852" molecular_function|protein binding|nucleus|mitochondrion|mitochondrial intermembrane space|oxidative phosphorylation|mitochondrion organization|stabilization of membrane potential|maintenance of protein location in nucleus|MICOS complex|protein-containing complex assembly|mitochondrial nucleoid organization|maintenance of synapse structure|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of mitochondrial transcription|positive regulation of cristae formation hsa05014 Amyotrophic lateral sclerosis CHCHD2 6655.399464 5876.257609 7434.54132 1.265183015 0.339346093 0.163864677 1 391.5169394 487.0517281 51142 coiled-coil-helix-coiled-coil-helix domain containing 2 "GO:0005515,GO:0005634,GO:0005739,GO:0005758,GO:0007005,GO:0008134,GO:0034599,GO:0043565,GO:0045944,GO:1900037,GO:1905448" protein binding|nucleus|mitochondrion|mitochondrial intermembrane space|mitochondrion organization|transcription factor binding|cellular response to oxidative stress|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|regulation of cellular response to hypoxia|positive regulation of mitochondrial ATP synthesis coupled electron transport CHCHD3 1290.349529 1198.556793 1382.142265 1.153172109 0.205607849 0.393834008 1 28.86496985 32.72927737 54927 coiled-coil-helix-coiled-coil-helix domain containing 3 "GO:0001401,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0007007,GO:0008053,GO:0019902,GO:0042407,GO:0060090,GO:0061617,GO:0070062,GO:0140275" SAM complex|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|inner mitochondrial membrane organization|mitochondrial fusion|phosphatase binding|cristae formation|molecular adaptor activity|MICOS complex|extracellular exosome|MIB complex CHCHD4 283.2372234 256.982229 309.4922178 1.204333152 0.268234537 0.407292639 1 8.555626481 10.13140406 131474 coiled-coil-helix-coiled-coil-helix domain containing 4 "GO:0005515,GO:0005739,GO:0005758,GO:0015035,GO:0018171,GO:0022417,GO:0033108,GO:0045041,GO:0051084" protein binding|mitochondrion|mitochondrial intermembrane space|protein disulfide oxidoreductase activity|peptidyl-cysteine oxidation|protein maturation by protein folding|mitochondrial respiratory chain complex assembly|protein import into mitochondrial intermembrane space|'de novo' posttranslational protein folding CHCHD5 280.2644368 279.8713344 280.6575392 1.002809165 0.004047086 1 1 23.26513822 22.94008961 84269 coiled-coil-helix-coiled-coil-helix domain containing 5 "GO:0005515,GO:0005739,GO:0005758,GO:0008150" protein binding|mitochondrion|mitochondrial intermembrane space|biological_process CHCHD6 222.2635709 208.0827765 236.4443652 1.136299549 0.184343206 0.605057963 1 0.839506754 0.9379684 84303 coiled-coil-helix-coiled-coil-helix domain containing 6 "GO:0001401,GO:0005515,GO:0005739,GO:0005743,GO:0005829,GO:0006974,GO:0007007,GO:0042407,GO:0061617,GO:0140275" SAM complex|protein binding|mitochondrion|mitochondrial inner membrane|cytosol|cellular response to DNA damage stimulus|inner mitochondrial membrane organization|cristae formation|MICOS complex|MIB complex CHCHD7 964.0087423 970.7061525 957.3113322 0.986200952 -0.020046449 0.939701619 1 27.71792578 26.87802315 79145 coiled-coil-helix-coiled-coil-helix domain containing 7 "GO:0003674,GO:0005575,GO:0005758,GO:0008150" molecular_function|cellular_component|mitochondrial intermembrane space|biological_process CHD1 1517.51703 1560.620824 1474.413236 0.944760709 -0.081979128 0.733021594 1 8.805102556 8.179512507 1105 chromodomain helicase DNA binding protein 1 "GO:0003677,GO:0003678,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0016569,GO:0032508,GO:0035064,GO:0043923" DNA binding|DNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|covalent chromatin modification|DNA duplex unwinding|methylated histone binding|positive regulation by host of viral transcription chromosome_remodelling_factor CHD1L 1358.30794 1405.599155 1311.016724 0.932710239 -0.10049914 0.677248157 1 17.27642643 15.84425553 9557 chromodomain helicase DNA binding protein 1 like "GO:0000166,GO:0000717,GO:0003678,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006281,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006338,GO:0006974,GO:0016887,GO:0033683,GO:0070911" "nucleotide binding|nucleotide-excision repair, DNA duplex unwinding|DNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|DNA repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|chromatin remodeling|cellular response to DNA damage stimulus|ATPase activity|nucleotide-excision repair, DNA incision|global genome nucleotide-excision repair" CHD2 2546.921549 2936.047977 2157.795121 0.734931833 -0.444317653 0.060321472 1 16.47996259 11.90897707 1106 chromodomain helicase DNA binding protein 2 "GO:0000978,GO:0003677,GO:0003678,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0006325,GO:0006357,GO:0007517,GO:0032508,GO:0042393" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA binding|DNA helicase activity|RNA binding|protein binding|ATP binding|nucleus|chromatin organization|regulation of transcription by RNA polymerase II|muscle organ development|DNA duplex unwinding|histone binding CHD3 3733.893321 3969.178962 3498.60768 0.881443672 -0.182059717 0.443897349 1 26.029465 22.55957869 1107 chromodomain helicase DNA binding protein 3 "GO:0000122,GO:0000976,GO:0003677,GO:0003678,GO:0003723,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0006333,GO:0006355,GO:0006357,GO:0007051,GO:0007098,GO:0008270,GO:0016581,GO:0016605,GO:0016887,GO:0032508,GO:0034451,GO:0036121,GO:0043044,GO:0070615,GO:1901796" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|DNA binding|DNA helicase activity|RNA binding|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|chromatin assembly or disassembly|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|spindle organization|centrosome cycle|zinc ion binding|NuRD complex|PML body|ATPase activity|DNA duplex unwinding|centriolar satellite|double-stranded DNA helicase activity|ATP-dependent chromatin remodeling|nucleosome-dependent ATPase activity|regulation of signal transduction by p53 class mediator" chromosome_remodelling_factor CHD4 6634.164216 6794.943068 6473.385364 0.95267691 -0.069941072 0.774398125 1 55.97061629 52.42964375 1108 chromodomain helicase DNA binding protein 4 "GO:0000785,GO:0001103,GO:0003677,GO:0003678,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005813,GO:0006357,GO:0008134,GO:0008270,GO:0016020,GO:0016581,GO:0031492,GO:0032508,GO:0032991,GO:0042826,GO:0043044,GO:0090575,GO:1901796" chromatin|RNA polymerase II repressing transcription factor binding|DNA binding|DNA helicase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|centrosome|regulation of transcription by RNA polymerase II|transcription factor binding|zinc ion binding|membrane|NuRD complex|nucleosomal DNA binding|DNA duplex unwinding|protein-containing complex|histone deacetylase binding|ATP-dependent chromatin remodeling|RNA polymerase II transcription regulator complex|regulation of signal transduction by p53 class mediator "hsa05165,hsa05203" Human papillomavirus infection|Viral carcinogenesis chromosome_remodelling_factor CHD5 6.485287494 6.242483296 6.728091692 1.0777909 0.108077311 1 1 0.033822321 0.035843392 26038 chromodomain helicase DNA binding protein 5 "GO:0000792,GO:0003677,GO:0003678,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0008285,GO:0016020,GO:0016581,GO:0016607,GO:0021895,GO:0032508,GO:0035093,GO:0043967,GO:0046872,GO:0061628,GO:0098532,GO:1901798" "heterochromatin|DNA binding|DNA helicase activity|ATP binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|negative regulation of cell population proliferation|membrane|NuRD complex|nuclear speck|cerebral cortex neuron differentiation|DNA duplex unwinding|spermatogenesis, exchange of chromosomal proteins|histone H4 acetylation|metal ion binding|H3K27me3 modified histone binding|histone H3-K27 trimethylation|positive regulation of signal transduction by p53 class mediator" CHD6 2179.663666 2479.306282 1880.02105 0.758285115 -0.399187691 0.091392011 1 9.861083583 7.352386849 84181 chromodomain helicase DNA binding protein 6 "GO:0001221,GO:0003677,GO:0003678,GO:0005524,GO:0005654,GO:0006325,GO:0008094,GO:0016032,GO:0032508,GO:0036091" transcription coregulator binding|DNA binding|DNA helicase activity|ATP binding|nucleoplasm|chromatin organization|DNA-dependent ATPase activity|viral process|DNA duplex unwinding|positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress CHD7 748.0719431 764.7042037 731.4396825 0.956500146 -0.064162906 0.804950127 1 3.419140239 3.215682286 55636 chromodomain helicase DNA binding protein 7 "GO:0000978,GO:0001501,GO:0001701,GO:0001974,GO:0003007,GO:0003222,GO:0003226,GO:0003678,GO:0003682,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006338,GO:0006355,GO:0006364,GO:0007417,GO:0007512,GO:0007605,GO:0007628,GO:0008015,GO:0009617,GO:0010880,GO:0021545,GO:0021553,GO:0021772,GO:0030217,GO:0030540,GO:0032508,GO:0035116,GO:0035909,GO:0036302,GO:0040018,GO:0042048,GO:0042472,GO:0043584,GO:0045944,GO:0048752,GO:0048806,GO:0050767,GO:0050890,GO:0060041,GO:0060123,GO:0060173,GO:0060324,GO:0060384,GO:0060411,GO:0060429,GO:0062009,GO:1990841" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|skeletal system development|in utero embryonic development|blood vessel remodeling|heart morphogenesis|ventricular trabecula myocardium morphogenesis|right ventricular compact myocardium morphogenesis|DNA helicase activity|chromatin binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|chromatin remodeling|regulation of transcription, DNA-templated|rRNA processing|central nervous system development|adult heart development|sensory perception of sound|adult walking behavior|blood circulation|response to bacterium|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|cranial nerve development|olfactory nerve development|olfactory bulb development|T cell differentiation|female genitalia development|DNA duplex unwinding|embryonic hindlimb morphogenesis|aorta morphogenesis|atrioventricular canal development|positive regulation of multicellular organism growth|olfactory behavior|inner ear morphogenesis|nose development|positive regulation of transcription by RNA polymerase II|semicircular canal morphogenesis|genitalia development|regulation of neurogenesis|cognition|retina development in camera-type eye|regulation of growth hormone secretion|limb development|face development|innervation|cardiac septum morphogenesis|epithelium development|secondary palate development|promoter-specific chromatin binding" other CHD8 2834.916091 3015.119432 2654.71275 0.880466864 -0.183659385 0.437819021 1 18.82224617 16.29504799 57680 chromodomain helicase DNA binding protein 8 "GO:0000122,GO:0001701,GO:0002039,GO:0003677,GO:0003678,GO:0003682,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0007420,GO:0008013,GO:0008094,GO:0016055,GO:0032508,GO:0032991,GO:0035064,GO:0035176,GO:0042393,GO:0043044,GO:0045892,GO:0045893,GO:0045944,GO:0045945,GO:0048565,GO:0060134,GO:0070016,GO:0071339,GO:0090090,GO:2000270" "negative regulation of transcription by RNA polymerase II|in utero embryonic development|p53 binding|DNA binding|DNA helicase activity|chromatin binding|protein binding|ATP binding|nucleus|nucleoplasm|brain development|beta-catenin binding|DNA-dependent ATPase activity|Wnt signaling pathway|DNA duplex unwinding|protein-containing complex|methylated histone binding|social behavior|histone binding|ATP-dependent chromatin remodeling|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase III|digestive tract development|prepulse inhibition|armadillo repeat domain binding|MLL1 complex|negative regulation of canonical Wnt signaling pathway|negative regulation of fibroblast apoptotic process" hsa04310 Wnt signaling pathway CHD9 1539.627419 1749.976151 1329.278687 0.759598173 -0.396691659 0.096049841 1 7.209032099 5.384334711 80205 chromodomain helicase DNA binding protein 9 "GO:0003677,GO:0003678,GO:0005524,GO:0005654,GO:0005829,GO:0006325,GO:0019216,GO:0032508" DNA binding|DNA helicase activity|ATP binding|nucleoplasm|cytosol|chromatin organization|regulation of lipid metabolic process|DNA duplex unwinding CHEK1 997.6837993 984.231533 1011.136066 1.027335573 0.038907506 0.878245681 1 10.37870539 10.4839922 1111 checkpoint kinase 1 "GO:0000077,GO:0000781,GO:0000785,GO:0000794,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006260,GO:0006281,GO:0006468,GO:0006915,GO:0006974,GO:0006975,GO:0010569,GO:0010767,GO:0016301,GO:0018107,GO:0019904,GO:0032991,GO:0035402,GO:0035407,GO:0035556,GO:0043231,GO:0044818,GO:0045787,GO:0045839,GO:0046602,GO:0048096,GO:0070317,GO:0071260,GO:0072425,GO:0090399,GO:0106310,GO:0106311,GO:1901796,GO:2000615" "DNA damage checkpoint|chromosome, telomeric region|chromatin|condensed nuclear chromosome|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|extracellular space|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|DNA replication|DNA repair|protein phosphorylation|apoptotic process|cellular response to DNA damage stimulus|DNA damage induced protein phosphorylation|regulation of double-strand break repair via homologous recombination|regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|kinase activity|peptidyl-threonine phosphorylation|protein domain specific binding|protein-containing complex|histone kinase activity (H3-T11 specific)|histone H3-T11 phosphorylation|intracellular signal transduction|intracellular membrane-bounded organelle|mitotic G2/M transition checkpoint|positive regulation of cell cycle|negative regulation of mitotic nuclear division|regulation of mitotic centrosome separation|chromatin-mediated maintenance of transcription|negative regulation of G0 to G1 transition|cellular response to mechanical stimulus|signal transduction involved in G2 DNA damage checkpoint|replicative senescence|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator|regulation of histone H3-K9 acetylation" "hsa04110,hsa04115,hsa04218,hsa05166,hsa05170,hsa05203" Cell cycle|p53 signaling pathway|Cellular senescence|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis CHEK2 893.8204342 831.2906922 956.3501762 1.150440135 0.202185913 0.417048481 1 15.38295992 17.40103623 11200 checkpoint kinase 2 "GO:0000077,GO:0000086,GO:0000781,GO:0001934,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0006302,GO:0006355,GO:0006468,GO:0006974,GO:0006975,GO:0006977,GO:0006978,GO:0008630,GO:0016301,GO:0016605,GO:0018105,GO:0019901,GO:0031625,GO:0035690,GO:0042176,GO:0042770,GO:0042771,GO:0042802,GO:0042803,GO:0044257,GO:0044773,GO:0045893,GO:0046777,GO:0046872,GO:0050821,GO:0051301,GO:0071157,GO:0071480,GO:0072428,GO:0090307,GO:0090399,GO:0106310,GO:0106311,GO:1901796,GO:1903416,GO:1903926,GO:2000002,GO:2000210" "DNA damage checkpoint|G2/M transition of mitotic cell cycle|chromosome, telomeric region|positive regulation of protein phosphorylation|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|double-strand break repair|regulation of transcription, DNA-templated|protein phosphorylation|cellular response to DNA damage stimulus|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|intrinsic apoptotic signaling pathway in response to DNA damage|kinase activity|PML body|peptidyl-serine phosphorylation|protein kinase binding|ubiquitin protein ligase binding|cellular response to drug|regulation of protein catabolic process|signal transduction in response to DNA damage|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|identical protein binding|protein homodimerization activity|cellular protein catabolic process|mitotic DNA damage checkpoint|positive regulation of transcription, DNA-templated|protein autophosphorylation|metal ion binding|protein stabilization|cell division|negative regulation of cell cycle arrest|cellular response to gamma radiation|signal transduction involved in intra-S DNA damage checkpoint|mitotic spindle assembly|replicative senescence|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator|response to glycoside|cellular response to bisphenol A|negative regulation of DNA damage checkpoint|positive regulation of anoikis" "hsa04110,hsa04115,hsa04218,hsa05166" Cell cycle|p53 signaling pathway|Cellular senescence|Human T-cell leukemia virus 1 infection CHERP 803.6699192 836.4927616 770.8470767 0.92152271 -0.117908375 0.642105015 1 10.95511197 9.926451886 10523 calcium homeostasis endoplasmic reticulum protein "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0006874,GO:0007399,GO:0008285,GO:0016020,GO:0033017,GO:0044325,GO:0048471,GO:0051209,GO:0070886" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|cytoplasm|cellular calcium ion homeostasis|nervous system development|negative regulation of cell population proliferation|membrane|sarcoplasmic reticulum membrane|ion channel binding|perinuclear region of cytoplasm|release of sequestered calcium ion into cytosol|positive regulation of calcineurin-NFAT signaling cascade" hsa03040 Spliceosome CHFR 565.1660767 580.5509465 549.7812068 0.946999071 -0.078565085 0.773215598 1 2.724972472 2.537364449 55743 checkpoint with forkhead and ring finger domains "GO:0000166,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0006511,GO:0007093,GO:0016567,GO:0016605,GO:0019941,GO:0031398,GO:0031648,GO:0032436,GO:0044779,GO:0046872,GO:0051301,GO:0061630" nucleotide binding|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|ubiquitin-dependent protein catabolic process|mitotic cell cycle checkpoint|protein ubiquitination|PML body|modification-dependent protein catabolic process|positive regulation of protein ubiquitination|protein destabilization|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|meiotic spindle checkpoint|metal ion binding|cell division|ubiquitin protein ligase activity CHGB 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.067658379 0.020486098 1114 chromogranin B "GO:0005179,GO:0005515,GO:0005615,GO:0005788,GO:0007165,GO:0030141,GO:0043687,GO:0044267" hormone activity|protein binding|extracellular space|endoplasmic reticulum lumen|signal transduction|secretory granule|post-translational protein modification|cellular protein metabolic process CHIC1 363.9686789 370.3873422 357.5500156 0.965340806 -0.05088973 0.872930756 1 2.09062842 1.984397601 53344 cysteine rich hydrophobic domain 1 "GO:0005886,GO:0031410" plasma membrane|cytoplasmic vesicle CHIC2 308.2864145 309.0029231 307.5699059 0.995362448 -0.006706136 0.99474488 1 1.113348507 1.089641315 26511 cysteine rich hydrophobic domain 2 "GO:0003674,GO:0005515,GO:0005794,GO:0005798,GO:0005886,GO:0008150,GO:0043231" molecular_function|protein binding|Golgi apparatus|Golgi-associated vesicle|plasma membrane|biological_process|intracellular membrane-bounded organelle CHID1 940.6390589 924.9279417 956.3501762 1.03397263 0.048197997 0.849444271 1 11.386783 11.57660634 66005 chitinase domain containing 1 "GO:0002576,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005764,GO:0005770,GO:0005802,GO:0005975,GO:0008061,GO:0016020,GO:0043202,GO:0045087,GO:0070062,GO:0070492,GO:1900016" platelet degranulation|protein binding|extracellular region|extracellular space|nucleus|lysosome|late endosome|trans-Golgi network|carbohydrate metabolic process|chitin binding|membrane|lysosomal lumen|innate immune response|extracellular exosome|oligosaccharide binding|negative regulation of cytokine production involved in inflammatory response CHKA 421.7166798 473.3883166 370.0450431 0.781694499 -0.355323209 0.212858025 1 5.053783638 3.884408353 1119 choline kinase alpha "GO:0004103,GO:0004104,GO:0004305,GO:0005524,GO:0005829,GO:0006580,GO:0006629,GO:0006646,GO:0006656,GO:0006657,GO:0006869,GO:0008144,GO:0009636,GO:0016310,GO:0019695,GO:0033265,GO:0042802,GO:1904681" choline kinase activity|cholinesterase activity|ethanolamine kinase activity|ATP binding|cytosol|ethanolamine metabolic process|lipid metabolic process|phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process|CDP-choline pathway|lipid transport|drug binding|response to toxic substance|phosphorylation|choline metabolic process|choline binding|identical protein binding|response to 3-methylcholanthrene "hsa00564,hsa05231" Glycerophospholipid metabolism|Choline metabolism in cancer CHKB 441.0637163 464.0245917 418.1028409 0.901035955 -0.150343419 0.598009556 1 16.80063746 14.88466484 1120 choline kinase beta "GO:0004103,GO:0004305,GO:0005524,GO:0005829,GO:0006646,GO:0006656,GO:0006657,GO:0016310" choline kinase activity|ethanolamine kinase activity|ATP binding|cytosol|phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process|CDP-choline pathway|phosphorylation "hsa00564,hsa05231" Glycerophospholipid metabolism|Choline metabolism in cancer CHM 1546.054799 1502.357647 1589.751951 1.058171438 0.081573382 0.734084847 1 8.545946107 8.89175245 1121 CHM Rab escort protein "GO:0004663,GO:0005092,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005968,GO:0006612,GO:0007264,GO:0007601,GO:0016192,GO:0018215,GO:0018344,GO:0031267,GO:0042981,GO:0043547,GO:0043687" Rab geranylgeranyltransferase activity|GDP-dissociation inhibitor activity|GTPase activator activity|protein binding|nucleus|cytoplasm|cytosol|Rab-protein geranylgeranyltransferase complex|protein targeting to membrane|small GTPase mediated signal transduction|visual perception|vesicle-mediated transport|protein phosphopantetheinylation|protein geranylgeranylation|small GTPase binding|regulation of apoptotic process|positive regulation of GTPase activity|post-translational protein modification CHML 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.014179003 0.019319499 1122 CHM like Rab escort protein "GO:0005092,GO:0005096,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005968,GO:0006886,GO:0007264,GO:0016192,GO:0018344,GO:0031267,GO:0043547,GO:0043687" GDP-dissociation inhibitor activity|GTPase activator activity|nucleus|nucleoplasm|cytoplasm|cytosol|Rab-protein geranylgeranyltransferase complex|intracellular protein transport|small GTPase mediated signal transduction|vesicle-mediated transport|protein geranylgeranylation|small GTPase binding|positive regulation of GTPase activity|post-translational protein modification CHMP1A 2453.207499 2343.012064 2563.402935 1.094063054 0.129695888 0.583948013 1 36.26515301 39.01243384 5119 charged multivesicular body protein 1A "GO:0000794,GO:0000815,GO:0005515,GO:0005769,GO:0005771,GO:0005815,GO:0006508,GO:0006997,GO:0007076,GO:0007080,GO:0008237,GO:0008270,GO:0010824,GO:0012505,GO:0015031,GO:0016192,GO:0016363,GO:0016458,GO:0019904,GO:0032509,GO:0036258,GO:0039702,GO:0042802,GO:0042803,GO:0045324,GO:0045786,GO:0045892,GO:0051301,GO:0061952,GO:0070062,GO:1901673,GO:1904903" "condensed nuclear chromosome|ESCRT III complex|protein binding|early endosome|multivesicular body|microtubule organizing center|proteolysis|nucleus organization|mitotic chromosome condensation|mitotic metaphase plate congression|metallopeptidase activity|zinc ion binding|regulation of centrosome duplication|endomembrane system|protein transport|vesicle-mediated transport|nuclear matrix|gene silencing|protein domain specific binding|endosome transport via multivesicular body sorting pathway|multivesicular body assembly|viral budding via host ESCRT complex|identical protein binding|protein homodimerization activity|late endosome to vacuole transport|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|cell division|midbody abscission|extracellular exosome|regulation of mitotic spindle assembly|ESCRT III complex disassembly" "hsa04144,hsa04217" Endocytosis|Necroptosis CHMP1B 1894.001473 1780.148153 2007.854792 1.127914431 0.173657623 0.46400222 1 31.33352083 34.75013769 57132 charged multivesicular body protein 1B "GO:0000815,GO:0005515,GO:0005654,GO:0005771,GO:0005829,GO:0006997,GO:0007080,GO:0010008,GO:0010824,GO:0015031,GO:0019904,GO:0030117,GO:0030496,GO:0031902,GO:0032509,GO:0036258,GO:0039702,GO:0042802,GO:0045184,GO:0045324,GO:0051301,GO:0061952,GO:0070062,GO:1901673,GO:1904903" ESCRT III complex|protein binding|nucleoplasm|multivesicular body|cytosol|nucleus organization|mitotic metaphase plate congression|endosome membrane|regulation of centrosome duplication|protein transport|protein domain specific binding|membrane coat|midbody|late endosome membrane|endosome transport via multivesicular body sorting pathway|multivesicular body assembly|viral budding via host ESCRT complex|identical protein binding|establishment of protein localization|late endosome to vacuole transport|cell division|midbody abscission|extracellular exosome|regulation of mitotic spindle assembly|ESCRT III complex disassembly "hsa04144,hsa04217" Endocytosis|Necroptosis CHMP2A 1034.624137 944.6958054 1124.552469 1.190385796 0.251429217 0.305414106 1 49.57392218 58.02460537 27243 charged multivesicular body protein 2A "GO:0000785,GO:0000815,GO:0005515,GO:0005635,GO:0005771,GO:0005829,GO:0006997,GO:0007080,GO:0010324,GO:0010458,GO:0010824,GO:0015031,GO:0016020,GO:0016197,GO:0016236,GO:0019058,GO:0019904,GO:0030117,GO:0031210,GO:0031468,GO:0031902,GO:0032509,GO:0036258,GO:0039702,GO:0045184,GO:0045324,GO:0050792,GO:0051258,GO:0051260,GO:0060548,GO:0061952,GO:0070062,GO:1901673,GO:1902188,GO:1903543,GO:1903723,GO:1904903" chromatin|ESCRT III complex|protein binding|nuclear envelope|multivesicular body|cytosol|nucleus organization|mitotic metaphase plate congression|membrane invagination|exit from mitosis|regulation of centrosome duplication|protein transport|membrane|endosomal transport|macroautophagy|viral life cycle|protein domain specific binding|membrane coat|phosphatidylcholine binding|nuclear envelope reassembly|late endosome membrane|endosome transport via multivesicular body sorting pathway|multivesicular body assembly|viral budding via host ESCRT complex|establishment of protein localization|late endosome to vacuole transport|regulation of viral process|protein polymerization|protein homooligomerization|negative regulation of cell death|midbody abscission|extracellular exosome|regulation of mitotic spindle assembly|positive regulation of viral release from host cell|positive regulation of exosomal secretion|negative regulation of centriole elongation|ESCRT III complex disassembly "hsa04144,hsa04217" Endocytosis|Necroptosis CHMP2B 1943.645658 1619.924415 2267.3669 1.399674503 0.485091364 0.04062262 1 32.52535318 44.76310986 25978 charged multivesicular body protein 2B "GO:0000815,GO:0005515,GO:0005737,GO:0005764,GO:0005768,GO:0005770,GO:0005771,GO:0005829,GO:0005886,GO:0006914,GO:0006997,GO:0007032,GO:0007080,GO:0010824,GO:0015031,GO:0016197,GO:0016236,GO:0019058,GO:0019904,GO:0031902,GO:0032509,GO:0036258,GO:0039702,GO:0045296,GO:0045324,GO:0050890,GO:0061763,GO:0061952,GO:0070050,GO:0070062,GO:1901673,GO:1902188,GO:1904903" ESCRT III complex|protein binding|cytoplasm|lysosome|endosome|late endosome|multivesicular body|cytosol|plasma membrane|autophagy|nucleus organization|endosome organization|mitotic metaphase plate congression|regulation of centrosome duplication|protein transport|endosomal transport|macroautophagy|viral life cycle|protein domain specific binding|late endosome membrane|endosome transport via multivesicular body sorting pathway|multivesicular body assembly|viral budding via host ESCRT complex|cadherin binding|late endosome to vacuole transport|cognition|multivesicular body-lysosome fusion|midbody abscission|neuron cellular homeostasis|extracellular exosome|regulation of mitotic spindle assembly|positive regulation of viral release from host cell|ESCRT III complex disassembly "hsa04144,hsa04217,hsa05014,hsa05022" Endocytosis|Necroptosis|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases CHMP3 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.053083152 0.016072904 51652 charged multivesicular body protein 3 "GO:0000815,GO:0005515,GO:0005770,GO:0005771,GO:0005829,GO:0005886,GO:0006915,GO:0006997,GO:0007080,GO:0010824,GO:0015031,GO:0016197,GO:0016236,GO:0019058,GO:0031210,GO:0031410,GO:0031902,GO:0032509,GO:0036258,GO:0039702,GO:0045324,GO:0050792,GO:0051258,GO:0061763,GO:0061952,GO:0070062,GO:0071985,GO:0097352,GO:1901673,GO:1902187,GO:1902188,GO:1903541,GO:1990381,GO:2000641" ESCRT III complex|protein binding|late endosome|multivesicular body|cytosol|plasma membrane|apoptotic process|nucleus organization|mitotic metaphase plate congression|regulation of centrosome duplication|protein transport|endosomal transport|macroautophagy|viral life cycle|phosphatidylcholine binding|cytoplasmic vesicle|late endosome membrane|endosome transport via multivesicular body sorting pathway|multivesicular body assembly|viral budding via host ESCRT complex|late endosome to vacuole transport|regulation of viral process|protein polymerization|multivesicular body-lysosome fusion|midbody abscission|extracellular exosome|multivesicular body sorting pathway|autophagosome maturation|regulation of mitotic spindle assembly|negative regulation of viral release from host cell|positive regulation of viral release from host cell|regulation of exosomal secretion|ubiquitin-specific protease binding|regulation of early endosome to late endosome transport "hsa04144,hsa04217" Endocytosis|Necroptosis CHMP4A 539.680967 517.0856997 562.2762343 1.087394671 0.120875663 0.657225872 1 28.15909534 30.10766513 29082 charged multivesicular body protein 4A "GO:0000815,GO:0005515,GO:0005634,GO:0005737,GO:0005768,GO:0005771,GO:0005829,GO:0005886,GO:0006620,GO:0006900,GO:0006997,GO:0007080,GO:0008289,GO:0009898,GO:0010324,GO:0016197,GO:0016236,GO:0019058,GO:0030117,GO:0030496,GO:0030659,GO:0031902,GO:0032511,GO:0036258,GO:0039702,GO:0042802,GO:0042803,GO:0051117,GO:0051258,GO:0061952,GO:0097320,GO:1901215,GO:1902902" ESCRT III complex|protein binding|nucleus|cytoplasm|endosome|multivesicular body|cytosol|plasma membrane|posttranslational protein targeting to endoplasmic reticulum membrane|vesicle budding from membrane|nucleus organization|mitotic metaphase plate congression|lipid binding|cytoplasmic side of plasma membrane|membrane invagination|endosomal transport|macroautophagy|viral life cycle|membrane coat|midbody|cytoplasmic vesicle membrane|late endosome membrane|late endosome to vacuole transport via multivesicular body sorting pathway|multivesicular body assembly|viral budding via host ESCRT complex|identical protein binding|protein homodimerization activity|ATPase binding|protein polymerization|midbody abscission|plasma membrane tubulation|negative regulation of neuron death|negative regulation of autophagosome assembly "hsa04144,hsa04217" Endocytosis|Necroptosis CHMP4B 3820.623726 3407.355466 4233.891986 1.242574198 0.313332003 0.187821142 1 113.5107982 138.6853822 128866 charged multivesicular body protein 4B "GO:0000281,GO:0000815,GO:0005515,GO:0005634,GO:0005635,GO:0005737,GO:0005768,GO:0005771,GO:0005829,GO:0006620,GO:0006900,GO:0006914,GO:0006997,GO:0007080,GO:0009898,GO:0010458,GO:0010824,GO:0016197,GO:0016236,GO:0019058,GO:0030117,GO:0030496,GO:0031468,GO:0031902,GO:0031982,GO:0032511,GO:0036258,GO:0036438,GO:0039702,GO:0042802,GO:0042803,GO:0045296,GO:0046755,GO:0050792,GO:0051258,GO:0060548,GO:0061952,GO:0070062,GO:0090148,GO:0090611,GO:1901215,GO:1901673,GO:1902188,GO:1902902" mitotic cytokinesis|ESCRT III complex|protein binding|nucleus|nuclear envelope|cytoplasm|endosome|multivesicular body|cytosol|posttranslational protein targeting to endoplasmic reticulum membrane|vesicle budding from membrane|autophagy|nucleus organization|mitotic metaphase plate congression|cytoplasmic side of plasma membrane|exit from mitosis|regulation of centrosome duplication|endosomal transport|macroautophagy|viral life cycle|membrane coat|midbody|nuclear envelope reassembly|late endosome membrane|vesicle|late endosome to vacuole transport via multivesicular body sorting pathway|multivesicular body assembly|maintenance of lens transparency|viral budding via host ESCRT complex|identical protein binding|protein homodimerization activity|cadherin binding|viral budding|regulation of viral process|protein polymerization|negative regulation of cell death|midbody abscission|extracellular exosome|membrane fission|ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway|negative regulation of neuron death|regulation of mitotic spindle assembly|positive regulation of viral release from host cell|negative regulation of autophagosome assembly "hsa04144,hsa04217" Endocytosis|Necroptosis CHMP4C 758.0653154 711.6430957 804.4875352 1.130464892 0.176916188 0.486910447 1 20.50706484 22.7945888 92421 charged multivesicular body protein 4C "GO:0000815,GO:0005515,GO:0005771,GO:0005829,GO:0006900,GO:0006997,GO:0007080,GO:0009838,GO:0009898,GO:0010824,GO:0015031,GO:0016197,GO:0016236,GO:0019058,GO:0030496,GO:0031902,GO:0032466,GO:0032511,GO:0036258,GO:0039702,GO:0042803,GO:0044878,GO:0050792,GO:0061952,GO:0090543,GO:0090611,GO:1901673,GO:1902188" ESCRT III complex|protein binding|multivesicular body|cytosol|vesicle budding from membrane|nucleus organization|mitotic metaphase plate congression|abscission|cytoplasmic side of plasma membrane|regulation of centrosome duplication|protein transport|endosomal transport|macroautophagy|viral life cycle|midbody|late endosome membrane|negative regulation of cytokinesis|late endosome to vacuole transport via multivesicular body sorting pathway|multivesicular body assembly|viral budding via host ESCRT complex|protein homodimerization activity|mitotic cytokinesis checkpoint|regulation of viral process|midbody abscission|Flemming body|ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway|regulation of mitotic spindle assembly|positive regulation of viral release from host cell "hsa04144,hsa04217" Endocytosis|Necroptosis CHMP5 2534.981212 2155.737565 2914.224859 1.35184584 0.434930641 0.065981247 1 60.51959587 80.4441314 51510 charged multivesicular body protein 5 "GO:0001919,GO:0005515,GO:0005634,GO:0005771,GO:0005829,GO:0006900,GO:0006997,GO:0007040,GO:0007080,GO:0008333,GO:0010008,GO:0010824,GO:0015031,GO:0016197,GO:0019058,GO:0032511,GO:0036258,GO:0045296,GO:0046755,GO:0061952,GO:0070062,GO:0071222,GO:0071225,GO:0071985,GO:1901673,GO:1904903" regulation of receptor recycling|protein binding|nucleus|multivesicular body|cytosol|vesicle budding from membrane|nucleus organization|lysosome organization|mitotic metaphase plate congression|endosome to lysosome transport|endosome membrane|regulation of centrosome duplication|protein transport|endosomal transport|viral life cycle|late endosome to vacuole transport via multivesicular body sorting pathway|multivesicular body assembly|cadherin binding|viral budding|midbody abscission|extracellular exosome|cellular response to lipopolysaccharide|cellular response to muramyl dipeptide|multivesicular body sorting pathway|regulation of mitotic spindle assembly|ESCRT III complex disassembly "hsa04144,hsa04217" Endocytosis|Necroptosis CHMP6 265.8124989 266.345954 265.2790439 0.99599427 -0.005790653 0.999099929 1 7.449892054 7.29588531 79643 charged multivesicular body protein 6 "GO:0000815,GO:0005515,GO:0005771,GO:0005829,GO:0006900,GO:0006997,GO:0007080,GO:0007175,GO:0010008,GO:0015031,GO:0016020,GO:0016197,GO:0016236,GO:0019058,GO:0031902,GO:0032511,GO:0036258,GO:0039702,GO:0042176,GO:0044877,GO:0047485,GO:0061952,GO:0070062,GO:1903541,GO:1904902" ESCRT III complex|protein binding|multivesicular body|cytosol|vesicle budding from membrane|nucleus organization|mitotic metaphase plate congression|negative regulation of epidermal growth factor-activated receptor activity|endosome membrane|protein transport|membrane|endosomal transport|macroautophagy|viral life cycle|late endosome membrane|late endosome to vacuole transport via multivesicular body sorting pathway|multivesicular body assembly|viral budding via host ESCRT complex|regulation of protein catabolic process|protein-containing complex binding|protein N-terminus binding|midbody abscission|extracellular exosome|regulation of exosomal secretion|ESCRT III complex assembly "hsa04144,hsa04217" Endocytosis|Necroptosis CHMP7 973.1353079 882.2709725 1063.999643 1.205978295 0.270203942 0.273270833 1 13.00336378 15.41936123 91782 charged multivesicular body protein 7 "GO:0000785,GO:0000815,GO:0005515,GO:0005635,GO:0005654,GO:0005771,GO:0005829,GO:0006900,GO:0006997,GO:0007080,GO:0010458,GO:0015031,GO:0016197,GO:0019058,GO:0031468,GO:0032511,GO:0036258,GO:0039702,GO:0045324,GO:0061952,GO:0071168,GO:1904903" chromatin|ESCRT III complex|protein binding|nuclear envelope|nucleoplasm|multivesicular body|cytosol|vesicle budding from membrane|nucleus organization|mitotic metaphase plate congression|exit from mitosis|protein transport|endosomal transport|viral life cycle|nuclear envelope reassembly|late endosome to vacuole transport via multivesicular body sorting pathway|multivesicular body assembly|viral budding via host ESCRT complex|late endosome to vacuole transport|midbody abscission|protein localization to chromatin|ESCRT III complex disassembly "hsa04144,hsa04217" Endocytosis|Necroptosis CHN1 459.5338851 444.2567279 474.8110423 1.068776256 0.095959862 0.736825342 1 6.346136258 6.669102127 1123 chimerin 1 "GO:0005096,GO:0005515,GO:0005829,GO:0008045,GO:0035556,GO:0043087,GO:0043547,GO:0046872,GO:0046875,GO:0048013,GO:0050770,GO:0051056" GTPase activator activity|protein binding|cytosol|motor neuron axon guidance|intracellular signal transduction|regulation of GTPase activity|positive regulation of GTPase activity|metal ion binding|ephrin receptor binding|ephrin receptor signaling pathway|regulation of axonogenesis|regulation of small GTPase mediated signal transduction CHN2 4.042768641 5.202069413 2.883467868 0.554292463 -0.851280704 0.745112452 1 0.055961476 0.030499963 1124 chimerin 2 "GO:0005096,GO:0005515,GO:0005829,GO:0016020,GO:0035556,GO:0043087,GO:0043547,GO:0045202,GO:0046872,GO:0051056" GTPase activator activity|protein binding|cytosol|membrane|intracellular signal transduction|regulation of GTPase activity|positive regulation of GTPase activity|synapse|metal ion binding|regulation of small GTPase mediated signal transduction CHODL 5.365615685 2.080827765 8.650403604 4.157193473 2.055609892 0.230262796 1 0.032263206 0.131879997 140578 chondrolectin "GO:0005515,GO:0005540,GO:0005737,GO:0005789,GO:0005813,GO:0005829,GO:0007517,GO:0016021,GO:0030246,GO:0048471,GO:0050772" protein binding|hyaluronic acid binding|cytoplasm|endoplasmic reticulum membrane|centrosome|cytosol|muscle organ development|integral component of membrane|carbohydrate binding|perinuclear region of cytoplasm|positive regulation of axonogenesis CHORDC1 1235.895762 1169.425204 1302.36632 1.113680735 0.155335706 0.521510367 1 18.62431329 20.39445734 26973 cysteine and histidine rich domain containing 1 "GO:0005515,GO:0005524,GO:0005575,GO:0008270,GO:0010824,GO:0043531,GO:0051298,GO:0051879,GO:0061077,GO:1900034,GO:2000299" protein binding|ATP binding|cellular_component|zinc ion binding|regulation of centrosome duplication|ADP binding|centrosome duplication|Hsp90 protein binding|chaperone-mediated protein folding|regulation of cellular response to heat|negative regulation of Rho-dependent protein serine/threonine kinase activity CHP1 1953.181147 1908.119061 1998.243233 1.047231944 0.066581009 0.780188964 1 30.03031769 30.92245643 11261 calcineurin like EF-hand protein 1 "GO:0000139,GO:0001578,GO:0001933,GO:0004860,GO:0005509,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005793,GO:0005829,GO:0005886,GO:0005925,GO:0006469,GO:0006611,GO:0006813,GO:0006903,GO:0006906,GO:0007264,GO:0008017,GO:0010923,GO:0015459,GO:0015630,GO:0019900,GO:0022406,GO:0030133,GO:0030214,GO:0031122,GO:0031397,GO:0031953,GO:0032088,GO:0032417,GO:0042308,GO:0048306,GO:0050821,GO:0051222,GO:0051259,GO:0051453,GO:0060050,GO:0061024,GO:0061025,GO:0070062,GO:0070885,GO:0071073,GO:0071468,GO:0090314,GO:1901214" Golgi membrane|microtubule bundle formation|negative regulation of protein phosphorylation|protein kinase inhibitor activity|calcium ion binding|protein binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cytosol|plasma membrane|focal adhesion|negative regulation of protein kinase activity|protein export from nucleus|potassium ion transport|vesicle targeting|vesicle fusion|small GTPase mediated signal transduction|microtubule binding|negative regulation of phosphatase activity|potassium channel regulator activity|microtubule cytoskeleton|kinase binding|membrane docking|transport vesicle|hyaluronan catabolic process|cytoplasmic microtubule organization|negative regulation of protein ubiquitination|negative regulation of protein autophosphorylation|negative regulation of NF-kappaB transcription factor activity|positive regulation of sodium:proton antiporter activity|negative regulation of protein import into nucleus|calcium-dependent protein binding|protein stabilization|positive regulation of protein transport|protein complex oligomerization|regulation of intracellular pH|positive regulation of protein glycosylation|membrane organization|membrane fusion|extracellular exosome|negative regulation of calcineurin-NFAT signaling cascade|positive regulation of phospholipid biosynthetic process|cellular response to acidic pH|positive regulation of protein targeting to membrane|regulation of neuron death CHPF 1719.408856 1637.611451 1801.206262 1.099898428 0.137370302 0.563856807 1 26.49175912 28.65065517 79586 chondroitin polymerizing factor "GO:0000139,GO:0005759,GO:0005829,GO:0008376,GO:0016021,GO:0030206,GO:0032580,GO:0046872,GO:0047238,GO:0050510" Golgi membrane|mitochondrial matrix|cytosol|acetylgalactosaminyltransferase activity|integral component of membrane|chondroitin sulfate biosynthetic process|Golgi cisterna membrane|metal ion binding|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHPF2 1199.019591 1248.496659 1149.542523 0.920741369 -0.119132126 0.624572199 1 24.51433851 22.19366437 54480 chondroitin polymerizing factor 2 "GO:0000139,GO:0008376,GO:0016020,GO:0016021,GO:0030206,GO:0032580,GO:0047238,GO:0050510" Golgi membrane|acetylgalactosaminyltransferase activity|membrane|integral component of membrane|chondroitin sulfate biosynthetic process|Golgi cisterna membrane|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHPT1 1097.267851 923.8875278 1270.648174 1.375327771 0.459775485 0.059472077 1 27.93551237 37.77757114 56994 choline phosphotransferase 1 "GO:0000139,GO:0001558,GO:0004142,GO:0005515,GO:0005789,GO:0005794,GO:0006629,GO:0006656,GO:0006657,GO:0006663,GO:0016020,GO:0016021,GO:0019992,GO:0043231,GO:0046872" Golgi membrane|regulation of cell growth|diacylglycerol cholinephosphotransferase activity|protein binding|endoplasmic reticulum membrane|Golgi apparatus|lipid metabolic process|phosphatidylcholine biosynthetic process|CDP-choline pathway|platelet activating factor biosynthetic process|membrane|integral component of membrane|diacylglycerol binding|intracellular membrane-bounded organelle|metal ion binding "hsa00440,hsa00564,hsa00565,hsa05231" Phosphonate and phosphinate metabolism|Glycerophospholipid metabolism|Ether lipid metabolism|Choline metabolism in cancer CHRAC1 1146.18178 1085.15168 1207.211881 1.112482157 0.153782196 0.528290681 1 23.3424227 25.53348895 54108 chromatin accessibility complex subunit 1 "GO:0003677,GO:0003887,GO:0005515,GO:0005634,GO:0006338,GO:0008622,GO:0008623,GO:0046982,GO:0071897" DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleus|chromatin remodeling|epsilon DNA polymerase complex|CHRAC|protein heterodimerization activity|DNA biosynthetic process CHRDL1 870.7879042 743.8959261 997.6798823 1.34115519 0.423476187 0.089288408 1 10.13281224 13.36226894 91851 chordin like 1 "GO:0001503,GO:0001654,GO:0005576,GO:0005788,GO:0007399,GO:0030154,GO:0030509,GO:0030514,GO:0043687,GO:0044267" ossification|eye development|extracellular region|endoplasmic reticulum lumen|nervous system development|cell differentiation|BMP signaling pathway|negative regulation of BMP signaling pathway|post-translational protein modification|cellular protein metabolic process CHRFAM7A 23.93958014 22.88910542 24.99005486 1.091788185 0.12669299 0.928499056 1 0.324707466 0.348579501 89832 CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion "GO:0005230,GO:0005515,GO:0005887,GO:0005892,GO:0007165,GO:0007268,GO:0007271,GO:0015464,GO:0030594,GO:0034220,GO:0042166,GO:0042391,GO:0043005,GO:0045202,GO:0050877" "extracellular ligand-gated ion channel activity|protein binding|integral component of plasma membrane|acetylcholine-gated channel complex|signal transduction|chemical synaptic transmission|synaptic transmission, cholinergic|acetylcholine receptor activity|neurotransmitter receptor activity|ion transmembrane transport|acetylcholine binding|regulation of membrane potential|neuron projection|synapse|nervous system process" CHRM4 21.65557714 26.01034707 17.30080721 0.665150956 -0.588246298 0.495969909 1 0.456019848 0.298246354 1132 cholinergic receptor muscarinic 4 "GO:0004993,GO:0005515,GO:0005886,GO:0005887,GO:0007165,GO:0007166,GO:0007186,GO:0007187,GO:0007197,GO:0007213,GO:0007268,GO:0016907,GO:0030425,GO:0030594,GO:0040012,GO:0045202,GO:0045211,GO:0098664" "G protein-coupled serotonin receptor activity|protein binding|plasma membrane|integral component of plasma membrane|signal transduction|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway|G protein-coupled acetylcholine receptor signaling pathway|chemical synaptic transmission|G protein-coupled acetylcholine receptor activity|dendrite|neurotransmitter receptor activity|regulation of locomotion|synapse|postsynaptic membrane|G protein-coupled serotonin receptor signaling pathway" "hsa04080,hsa04725,hsa04810" Neuroactive ligand-receptor interaction|Cholinergic synapse|Regulation of actin cytoskeleton CHRNA10 4.042768641 5.202069413 2.883467868 0.554292463 -0.851280704 0.745112452 1 0.138328293 0.075391289 57053 cholinergic receptor nicotinic alpha 10 subunit "GO:0004888,GO:0005102,GO:0005262,GO:0005887,GO:0007165,GO:0007204,GO:0007268,GO:0007271,GO:0016020,GO:0022848,GO:0030424,GO:0030594,GO:0034220,GO:0042127,GO:0042391,GO:0042472,GO:0043005,GO:0043204,GO:0045202,GO:0050877,GO:0050910,GO:0060079,GO:0070373,GO:0070588,GO:0098981,GO:0099060" "transmembrane signaling receptor activity|signaling receptor binding|calcium channel activity|integral component of plasma membrane|signal transduction|positive regulation of cytosolic calcium ion concentration|chemical synaptic transmission|synaptic transmission, cholinergic|membrane|acetylcholine-gated cation-selective channel activity|axon|neurotransmitter receptor activity|ion transmembrane transport|regulation of cell population proliferation|regulation of membrane potential|inner ear morphogenesis|neuron projection|perikaryon|synapse|nervous system process|detection of mechanical stimulus involved in sensory perception of sound|excitatory postsynaptic potential|negative regulation of ERK1 and ERK2 cascade|calcium ion transmembrane transport|cholinergic synapse|integral component of postsynaptic specialization membrane" hsa04080 Neuroactive ligand-receptor interaction CHRNA5 243.398941 233.0527097 253.7451724 1.088788767 0.122724087 0.725843323 1 4.385611701 4.695101517 1138 cholinergic receptor nicotinic alpha 5 subunit "GO:0005515,GO:0005886,GO:0005887,GO:0005892,GO:0007165,GO:0007268,GO:0007271,GO:0015276,GO:0015464,GO:0022848,GO:0030594,GO:0034220,GO:0035094,GO:0035095,GO:0042391,GO:0043005,GO:0045202,GO:0045211,GO:0050877,GO:0060079,GO:0098691,GO:2000300" "protein binding|plasma membrane|integral component of plasma membrane|acetylcholine-gated channel complex|signal transduction|chemical synaptic transmission|synaptic transmission, cholinergic|ligand-gated ion channel activity|acetylcholine receptor activity|acetylcholine-gated cation-selective channel activity|neurotransmitter receptor activity|ion transmembrane transport|response to nicotine|behavioral response to nicotine|regulation of membrane potential|neuron projection|synapse|postsynaptic membrane|nervous system process|excitatory postsynaptic potential|dopaminergic synapse|regulation of synaptic vesicle exocytosis" hsa04080 Neuroactive ligand-receptor interaction CHRNA7 27.62065769 31.21241648 24.0288989 0.769850643 -0.377349516 0.642993258 1 0.243210586 0.184102688 1139 cholinergic receptor nicotinic alpha 7 subunit "GO:0000187,GO:0001540,GO:0001666,GO:0001934,GO:0005216,GO:0005262,GO:0005515,GO:0005886,GO:0005887,GO:0005892,GO:0006811,GO:0006816,GO:0006874,GO:0007165,GO:0007268,GO:0007271,GO:0007611,GO:0007613,GO:0007614,GO:0008284,GO:0015464,GO:0015643,GO:0016021,GO:0017081,GO:0022848,GO:0030594,GO:0032720,GO:0034220,GO:0035094,GO:0042166,GO:0042391,GO:0042803,GO:0043005,GO:0044853,GO:0045202,GO:0045211,GO:0045766,GO:0050808,GO:0050877,GO:0050890,GO:0050893,GO:0051247,GO:0060079,GO:0070374,GO:0070588,GO:0095500,GO:0097061,GO:0098794,GO:0098815,GO:0140059,GO:1900273,GO:1901214,GO:1902004,GO:1902430,GO:1902991,GO:1904645,GO:1905144,GO:1905906,GO:1905920,GO:2000463" "activation of MAPK activity|amyloid-beta binding|response to hypoxia|positive regulation of protein phosphorylation|ion channel activity|calcium channel activity|protein binding|plasma membrane|integral component of plasma membrane|acetylcholine-gated channel complex|ion transport|calcium ion transport|cellular calcium ion homeostasis|signal transduction|chemical synaptic transmission|synaptic transmission, cholinergic|learning or memory|memory|short-term memory|positive regulation of cell population proliferation|acetylcholine receptor activity|toxic substance binding|integral component of membrane|chloride channel regulator activity|acetylcholine-gated cation-selective channel activity|neurotransmitter receptor activity|negative regulation of tumor necrosis factor production|ion transmembrane transport|response to nicotine|acetylcholine binding|regulation of membrane potential|protein homodimerization activity|neuron projection|plasma membrane raft|synapse|postsynaptic membrane|positive regulation of angiogenesis|synapse organization|nervous system process|cognition|sensory processing|positive regulation of protein metabolic process|excitatory postsynaptic potential|positive regulation of ERK1 and ERK2 cascade|calcium ion transmembrane transport|acetylcholine receptor signaling pathway|dendritic spine organization|postsynapse|modulation of excitatory postsynaptic potential|dendrite arborization|positive regulation of long-term synaptic potentiation|regulation of neuron death|positive regulation of amyloid-beta formation|negative regulation of amyloid-beta formation|regulation of amyloid precursor protein catabolic process|response to amyloid-beta|response to acetylcholine|regulation of amyloid fibril formation|positive regulation of CoA-transferase activity|positive regulation of excitatory postsynaptic potential" "hsa04020,hsa04080,hsa04725,hsa05010,hsa05022,hsa05033,hsa05204" Calcium signaling pathway|Neuroactive ligand-receptor interaction|Cholinergic synapse|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Nicotine addiction|Chemical carcinogenesis CHRNB1 668.1028844 747.0171677 589.188601 0.788721634 -0.34241188 0.184540608 1 15.57302081 12.07724276 1140 cholinergic receptor nicotinic beta 1 subunit "GO:0001941,GO:0003009,GO:0005515,GO:0005887,GO:0005892,GO:0006812,GO:0006936,GO:0007165,GO:0007268,GO:0007271,GO:0007274,GO:0015267,GO:0015276,GO:0015464,GO:0022848,GO:0030594,GO:0031594,GO:0034220,GO:0035095,GO:0042166,GO:0042391,GO:0043005,GO:0045202,GO:0048747,GO:0050877,GO:0060079,GO:0099060,GO:1904315" "postsynaptic membrane organization|skeletal muscle contraction|protein binding|integral component of plasma membrane|acetylcholine-gated channel complex|cation transport|muscle contraction|signal transduction|chemical synaptic transmission|synaptic transmission, cholinergic|neuromuscular synaptic transmission|channel activity|ligand-gated ion channel activity|acetylcholine receptor activity|acetylcholine-gated cation-selective channel activity|neurotransmitter receptor activity|neuromuscular junction|ion transmembrane transport|behavioral response to nicotine|acetylcholine binding|regulation of membrane potential|neuron projection|synapse|muscle fiber development|nervous system process|excitatory postsynaptic potential|integral component of postsynaptic specialization membrane|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential" hsa04080 Neuroactive ligand-receptor interaction CHRNB4 2.080827765 4.161655531 0 0 #NAME? 0.234194363 1 0.028004023 0 1143 cholinergic receptor nicotinic beta 4 subunit "GO:0005515,GO:0005886,GO:0005887,GO:0005892,GO:0006811,GO:0007165,GO:0007268,GO:0007271,GO:0015276,GO:0015464,GO:0016021,GO:0022848,GO:0030594,GO:0034220,GO:0035579,GO:0042166,GO:0042391,GO:0043005,GO:0043312,GO:0044877,GO:0045202,GO:0045211,GO:0046928,GO:0050877,GO:0060079,GO:0060084,GO:0070821" "protein binding|plasma membrane|integral component of plasma membrane|acetylcholine-gated channel complex|ion transport|signal transduction|chemical synaptic transmission|synaptic transmission, cholinergic|ligand-gated ion channel activity|acetylcholine receptor activity|integral component of membrane|acetylcholine-gated cation-selective channel activity|neurotransmitter receptor activity|ion transmembrane transport|specific granule membrane|acetylcholine binding|regulation of membrane potential|neuron projection|neutrophil degranulation|protein-containing complex binding|synapse|postsynaptic membrane|regulation of neurotransmitter secretion|nervous system process|excitatory postsynaptic potential|synaptic transmission involved in micturition|tertiary granule membrane" "hsa04080,hsa04725" Neuroactive ligand-receptor interaction|Cholinergic synapse CHRNE 2.923096831 1.040413883 4.80577978 4.619103859 2.207612985 0.416510993 1 0.021706402 0.098586342 1145 cholinergic receptor nicotinic epsilon subunit "GO:0005886,GO:0005887,GO:0005892,GO:0006936,GO:0007165,GO:0007268,GO:0007271,GO:0008324,GO:0015464,GO:0022848,GO:0030594,GO:0031594,GO:0034220,GO:0042391,GO:0043005,GO:0045202,GO:0045211,GO:0050877,GO:0060079,GO:0098655,GO:1904315" "plasma membrane|integral component of plasma membrane|acetylcholine-gated channel complex|muscle contraction|signal transduction|chemical synaptic transmission|synaptic transmission, cholinergic|cation transmembrane transporter activity|acetylcholine receptor activity|acetylcholine-gated cation-selective channel activity|neurotransmitter receptor activity|neuromuscular junction|ion transmembrane transport|regulation of membrane potential|neuron projection|synapse|postsynaptic membrane|nervous system process|excitatory postsynaptic potential|cation transmembrane transport|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential" hsa04080 Neuroactive ligand-receptor interaction CHST10 378.7225573 429.6909335 327.754181 0.762767272 -0.390685152 0.183325874 1 6.267235688 4.700448039 9486 carbohydrate sulfotransferase 10 "GO:0000139,GO:0005794,GO:0007155,GO:0008146,GO:0016020,GO:0016021,GO:0016051,GO:0016232,GO:0030166" Golgi membrane|Golgi apparatus|cell adhesion|sulfotransferase activity|membrane|integral component of membrane|carbohydrate biosynthetic process|HNK-1 sulfotransferase activity|proteoglycan biosynthetic process hsa00515 Mannose type O-glycan biosynthesis CHST11 1295.347809 1317.163975 1273.531642 0.96687403 -0.048600155 0.842900783 1 11.90223849 11.31539509 50515 carbohydrate sulfotransferase 11 "GO:0000139,GO:0001537,GO:0001701,GO:0002063,GO:0007585,GO:0008146,GO:0009791,GO:0016020,GO:0016021,GO:0016051,GO:0030166,GO:0030206,GO:0030512,GO:0033037,GO:0036342,GO:0042127,GO:0042733,GO:0043066,GO:0047756,GO:0048589,GO:0048703,GO:0050659" Golgi membrane|N-acetylgalactosamine 4-O-sulfotransferase activity|in utero embryonic development|chondrocyte development|respiratory gaseous exchange by respiratory system|sulfotransferase activity|post-embryonic development|membrane|integral component of membrane|carbohydrate biosynthetic process|proteoglycan biosynthetic process|chondroitin sulfate biosynthetic process|negative regulation of transforming growth factor beta receptor signaling pathway|polysaccharide localization|post-anal tail morphogenesis|regulation of cell population proliferation|embryonic digit morphogenesis|negative regulation of apoptotic process|chondroitin 4-sulfotransferase activity|developmental growth|embryonic viscerocranium morphogenesis|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHST12 319.7561193 269.4671956 370.0450431 1.373247093 0.457591238 0.138209055 1 7.945286724 10.72826373 55501 carbohydrate sulfotransferase 12 "GO:0000139,GO:0008146,GO:0016020,GO:0016051,GO:0030166,GO:0030173,GO:0030206,GO:0030208,GO:0047756,GO:0050656" Golgi membrane|sulfotransferase activity|membrane|carbohydrate biosynthetic process|proteoglycan biosynthetic process|integral component of Golgi membrane|chondroitin sulfate biosynthetic process|dermatan sulfate biosynthetic process|chondroitin 4-sulfotransferase activity|3'-phosphoadenosine 5'-phosphosulfate binding hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHST14 517.2674091 483.7924554 550.7423628 1.138385596 0.186989313 0.493298899 1 11.87085709 13.28748072 113189 carbohydrate sulfotransferase 14 "GO:0000139,GO:0001537,GO:0008146,GO:0016021,GO:0016051,GO:0030208,GO:0042301,GO:0050655,GO:0070062" Golgi membrane|N-acetylgalactosamine 4-O-sulfotransferase activity|sulfotransferase activity|integral component of membrane|carbohydrate biosynthetic process|dermatan sulfate biosynthetic process|phosphate ion binding|dermatan sulfate proteoglycan metabolic process|extracellular exosome hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHST15 10.96900515 10.40413883 11.53387147 1.108584926 0.148719296 0.986798089 1 0.053704398 0.058539633 51363 carbohydrate sulfotransferase 15 "GO:0000139,GO:0005515,GO:0016021,GO:0019319,GO:0030206,GO:0050656,GO:0050659" Golgi membrane|protein binding|integral component of membrane|hexose biosynthetic process|chondroitin sulfate biosynthetic process|3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHST2 46.9129739 58.26317743 35.56277037 0.610381581 -0.712216666 0.248215732 1 0.75069983 0.45054577 9435 carbohydrate sulfotransferase 2 "GO:0000139,GO:0001517,GO:0005654,GO:0005794,GO:0005802,GO:0005829,GO:0005975,GO:0006044,GO:0006790,GO:0006954,GO:0007275,GO:0008146,GO:0016021,GO:0018146,GO:0031228" Golgi membrane|N-acetylglucosamine 6-O-sulfotransferase activity|nucleoplasm|Golgi apparatus|trans-Golgi network|cytosol|carbohydrate metabolic process|N-acetylglucosamine metabolic process|sulfur compound metabolic process|inflammatory response|multicellular organism development|sulfotransferase activity|integral component of membrane|keratan sulfate biosynthetic process|intrinsic component of Golgi membrane hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate CHST3 766.7692105 877.0689031 656.4695179 0.748481123 -0.417962163 0.098348262 1 4.793891374 3.528094584 9469 carbohydrate sulfotransferase 3 "GO:0000139,GO:0001517,GO:0005802,GO:0005975,GO:0006044,GO:0006790,GO:0008146,GO:0008459,GO:0016021,GO:0030206" Golgi membrane|N-acetylglucosamine 6-O-sulfotransferase activity|trans-Golgi network|carbohydrate metabolic process|N-acetylglucosamine metabolic process|sulfur compound metabolic process|sulfotransferase activity|chondroitin 6-sulfotransferase activity|integral component of membrane|chondroitin sulfate biosynthetic process hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHST5 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.046869705 0.042574653 23563 carbohydrate sulfotransferase 5 "GO:0000139,GO:0001517,GO:0005794,GO:0005802,GO:0005975,GO:0006044,GO:0006477,GO:0006790,GO:0008146,GO:0016021,GO:0018146,GO:0031228" Golgi membrane|N-acetylglucosamine 6-O-sulfotransferase activity|Golgi apparatus|trans-Golgi network|carbohydrate metabolic process|N-acetylglucosamine metabolic process|protein sulfation|sulfur compound metabolic process|sulfotransferase activity|integral component of membrane|keratan sulfate biosynthetic process|intrinsic component of Golgi membrane CHST6 5.925451589 4.161655531 7.689247648 1.847641543 0.88568489 0.619277139 1 0.02409154 0.043767673 4166 carbohydrate sulfotransferase 6 "GO:0000139,GO:0001517,GO:0005794,GO:0005802,GO:0005975,GO:0006044,GO:0006790,GO:0016021,GO:0018146" Golgi membrane|N-acetylglucosamine 6-O-sulfotransferase activity|Golgi apparatus|trans-Golgi network|carbohydrate metabolic process|N-acetylglucosamine metabolic process|sulfur compound metabolic process|integral component of membrane|keratan sulfate biosynthetic process hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate CHST7 256.9243215 260.1034707 253.7451724 0.975554735 -0.035705275 0.926650841 1 5.793507587 5.557307138 56548 carbohydrate sulfotransferase 7 "GO:0000139,GO:0001517,GO:0005802,GO:0005976,GO:0006044,GO:0006790,GO:0008459,GO:0016021,GO:0030206" Golgi membrane|N-acetylglucosamine 6-O-sulfotransferase activity|trans-Golgi network|polysaccharide metabolic process|N-acetylglucosamine metabolic process|sulfur compound metabolic process|chondroitin 6-sulfotransferase activity|integral component of membrane|chondroitin sulfate biosynthetic process hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHST9 13.12909084 16.64662212 9.61155956 0.577387982 -0.792387015 0.459078304 1 0.075531341 0.042881119 83539 carbohydrate sulfotransferase 9 "GO:0000139,GO:0001537,GO:0005576,GO:0006790,GO:0008146,GO:0016021,GO:0016051,GO:0030166,GO:0030203,GO:0030206,GO:0042446" Golgi membrane|N-acetylgalactosamine 4-O-sulfotransferase activity|extracellular region|sulfur compound metabolic process|sulfotransferase activity|integral component of membrane|carbohydrate biosynthetic process|proteoglycan biosynthetic process|glycosaminoglycan metabolic process|chondroitin sulfate biosynthetic process|hormone biosynthetic process hsa00513 Various types of N-glycan biosynthesis CHSY1 977.9102908 1058.100919 897.7196629 0.84842537 -0.237140334 0.336205444 1 11.40094919 9.510992406 22856 chondroitin sulfate synthase 1 "GO:0000139,GO:0002063,GO:0005576,GO:0008376,GO:0009954,GO:0016020,GO:0016021,GO:0030206,GO:0030279,GO:0031667,GO:0032580,GO:0045880,GO:0046872,GO:0047238,GO:0050510,GO:0051923,GO:0060349" Golgi membrane|chondrocyte development|extracellular region|acetylgalactosaminyltransferase activity|proximal/distal pattern formation|membrane|integral component of membrane|chondroitin sulfate biosynthetic process|negative regulation of ossification|response to nutrient levels|Golgi cisterna membrane|positive regulation of smoothened signaling pathway|metal ion binding|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|sulfation|bone morphogenesis hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHSY3 236.6607885 258.0226429 215.2989341 0.834418762 -0.261156498 0.448234789 1 0.713185945 0.585137612 337876 chondroitin sulfate synthase 3 "GO:0000139,GO:0008376,GO:0016021,GO:0030206,GO:0032580,GO:0046872,GO:0047238,GO:0050510" Golgi membrane|acetylgalactosaminyltransferase activity|integral component of membrane|chondroitin sulfate biosynthetic process|Golgi cisterna membrane|metal ion binding|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHTF18 546.1360719 598.2379825 494.0341614 0.825815438 -0.276108707 0.30360157 1 10.26917389 8.33853361 63922 chromosome transmission fidelity factor 18 "GO:0003677,GO:0003689,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006260,GO:0007049,GO:0016020,GO:0017116,GO:0031390,GO:0032508,GO:1900264" DNA binding|DNA clamp loader activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|DNA replication|cell cycle|membrane|single-stranded DNA helicase activity|Ctf18 RFC-like complex|DNA duplex unwinding|positive regulation of DNA-directed DNA polymerase activity CHTOP 1375.504951 1365.023014 1385.986889 1.015357891 0.021988335 0.930116658 1 34.98980281 34.93267327 26097 chromatin target of PRMT1 "GO:0000346,GO:0001701,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006405,GO:0006406,GO:0008284,GO:0008327,GO:0016607,GO:0031062,GO:0031124,GO:0032781,GO:0036464,GO:0051096" transcription export complex|in utero embryonic development|RNA binding|protein binding|nucleoplasm|nucleolus|RNA export from nucleus|mRNA export from nucleus|positive regulation of cell population proliferation|methyl-CpG binding|nuclear speck|positive regulation of histone methylation|mRNA 3'-end processing|positive regulation of ATPase activity|cytoplasmic ribonucleoprotein granule|positive regulation of helicase activity CHUK 2122.596231 2078.746938 2166.445525 1.042188198 0.059615822 0.802587004 1 15.39962569 15.78074471 1147 component of inhibitor of nuclear factor kappa B kinase complex "GO:0002223,GO:0002479,GO:0002756,GO:0003009,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006954,GO:0006955,GO:0007249,GO:0007252,GO:0007266,GO:0008384,GO:0008385,GO:0009615,GO:0009636,GO:0009653,GO:0009898,GO:0010034,GO:0010803,GO:0018105,GO:0032088,GO:0032496,GO:0032727,GO:0033194,GO:0033209,GO:0034614,GO:0035631,GO:0035666,GO:0038061,GO:0038095,GO:0042493,GO:0042803,GO:0043123,GO:0043200,GO:0044877,GO:0045087,GO:0045893,GO:0045944,GO:0046982,GO:0050852,GO:0051092,GO:0051146,GO:0051403,GO:0061847,GO:0070498,GO:0071276,GO:0071356,GO:0097110,GO:0098586,GO:1990459" "stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|MyD88-independent toll-like receptor signaling pathway|skeletal muscle contraction|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|inflammatory response|immune response|I-kappaB kinase/NF-kappaB signaling|I-kappaB phosphorylation|Rho protein signal transduction|IkappaB kinase activity|IkappaB kinase complex|response to virus|response to toxic substance|anatomical structure morphogenesis|cytoplasmic side of plasma membrane|response to acetate|regulation of tumor necrosis factor-mediated signaling pathway|peptidyl-serine phosphorylation|negative regulation of NF-kappaB transcription factor activity|response to lipopolysaccharide|positive regulation of interferon-alpha production|response to hydroperoxide|tumor necrosis factor-mediated signaling pathway|cellular response to reactive oxygen species|CD40 receptor complex|TRIF-dependent toll-like receptor signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|response to drug|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to amino acid|protein-containing complex binding|innate immune response|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|striated muscle cell differentiation|stress-activated MAPK cascade|response to cholecystokinin|interleukin-1-mediated signaling pathway|cellular response to cadmium ion|cellular response to tumor necrosis factor|scaffold protein binding|cellular response to virus|transferrin receptor binding" "hsa01523,hsa04010,hsa04014,hsa04062,hsa04064,hsa04068,hsa04150,hsa04151,hsa04210,hsa04380,hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04920,hsa05010,hsa05120,hsa05130,hsa05131,hsa05132,hsa05135,hsa05142,hsa05145,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05212,hsa05215,hsa05220,hsa05221,hsa05222,hsa05235,hsa05418" Antifolate resistance|MAPK signaling pathway|Ras signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|FoxO signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Adipocytokine signaling pathway|Alzheimer disease|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Chagas disease|Toxoplasmosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Pancreatic cancer|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis CHURC1 437.2241229 451.5396251 422.9086206 0.936592487 -0.094506629 0.744180649 1 6.844032915 6.302805975 91612 churchill domain containing 1 "GO:0005515,GO:0007275,GO:0008270,GO:0045893" "protein binding|multicellular organism development|zinc ion binding|positive regulation of transcription, DNA-templated" CIAO1 1696.29584 1749.976151 1642.615529 0.938650237 -0.091340418 0.702127008 1 23.15146525 21.36748735 9391 cytosolic iron-sulfur assembly component 1 "GO:0005515,GO:0005737,GO:0006357,GO:0007059,GO:0008284,GO:0016226,GO:0071817,GO:0097361,GO:0097428" protein binding|cytoplasm|regulation of transcription by RNA polymerase II|chromosome segregation|positive regulation of cell population proliferation|iron-sulfur cluster assembly|MMXD complex|CIA complex|protein maturation by iron-sulfur cluster transfer CIAO2A 644.7835052 576.389291 713.1777193 1.237319517 0.307218101 0.237042856 1 33.47207519 40.72261708 84191 cytosolic iron-sulfur assembly component 2A "GO:0005515,GO:0005654,GO:0005829,GO:0007059,GO:0016226,GO:0046872,GO:0097361,GO:0097428,GO:0106035" protein binding|nucleoplasm|cytosol|chromosome segregation|iron-sulfur cluster assembly|metal ion binding|CIA complex|protein maturation by iron-sulfur cluster transfer|protein maturation by [4Fe-4S] cluster transfer CIAO2B 926.9060872 816.7248979 1037.087277 1.269812245 0.344615196 0.164054219 1 65.25015976 81.46897811 51647 cytosolic iron-sulfur assembly component 2B "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005819,GO:0005829,GO:0007059,GO:0016226,GO:0030496,GO:0071817,GO:0097361,GO:0097428,GO:0106035" protein binding|nucleus|nucleoplasm|cytoplasm|spindle|cytosol|chromosome segregation|iron-sulfur cluster assembly|midbody|MMXD complex|CIA complex|protein maturation by iron-sulfur cluster transfer|protein maturation by [4Fe-4S] cluster transfer CIAO3 306.7157329 330.8516147 282.5798511 0.854098449 -0.22752572 0.470085259 1 8.110676434 6.811396911 64428 cytosolic iron-sulfur assembly component 3 "GO:0001666,GO:0002244,GO:0005515,GO:0010468,GO:0016226,GO:0032364,GO:0046872,GO:0051539,GO:0097361" "response to hypoxia|hematopoietic progenitor cell differentiation|protein binding|regulation of gene expression|iron-sulfur cluster assembly|oxygen homeostasis|metal ion binding|4 iron, 4 sulfur cluster binding|CIA complex" CIAPIN1 904.9724929 884.3518002 925.5931856 1.046634592 0.065757847 0.794820396 1 23.35290955 24.03295981 57019 cytokine induced apoptosis inhibitor 1 "GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005758,GO:0006915,GO:0008168,GO:0009055,GO:0016226,GO:0022900,GO:0030097,GO:0043066,GO:0046872,GO:0051537,GO:0051539" "protein binding|nucleoplasm|nucleolus|cytoplasm|mitochondrion|mitochondrial intermembrane space|apoptotic process|methyltransferase activity|electron transfer activity|iron-sulfur cluster assembly|electron transport chain|hemopoiesis|negative regulation of apoptotic process|metal ion binding|2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding" CIB1 2297.93358 1963.260997 2632.606163 1.340935397 0.423239733 0.073526495 1 73.68187839 97.14931048 10519 calcium and integrin binding 1 "GO:0001525,GO:0001933,GO:0001934,GO:0001954,GO:0002931,GO:0005509,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005794,GO:0005813,GO:0005886,GO:0006302,GO:0006915,GO:0006974,GO:0007026,GO:0007113,GO:0007155,GO:0007286,GO:0008022,GO:0008284,GO:0008285,GO:0008427,GO:0010977,GO:0016020,GO:0016324,GO:0019901,GO:0030027,GO:0030220,GO:0030291,GO:0030307,GO:0030335,GO:0030425,GO:0030426,GO:0031122,GO:0031267,GO:0031982,GO:0032433,GO:0032587,GO:0033630,GO:0038163,GO:0042127,GO:0042383,GO:0043005,GO:0043025,GO:0043066,GO:0043085,GO:0043204,GO:0043495,GO:0044325,GO:0045653,GO:0048471,GO:0051092,GO:0051301,GO:0051302,GO:0051898,GO:0070062,GO:0070374,GO:0070886,GO:0071356,GO:0071363,GO:0071901,GO:0071902,GO:0071944,GO:0090050,GO:0090314,GO:0097191,GO:1900026,GO:1903078,GO:1990090,GO:2000256" angiogenesis|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of cell-matrix adhesion|response to ischemia|calcium ion binding|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|Golgi apparatus|centrosome|plasma membrane|double-strand break repair|apoptotic process|cellular response to DNA damage stimulus|negative regulation of microtubule depolymerization|endomitotic cell cycle|cell adhesion|spermatid development|protein C-terminus binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|calcium-dependent protein kinase inhibitor activity|negative regulation of neuron projection development|membrane|apical plasma membrane|protein kinase binding|lamellipodium|platelet formation|protein serine/threonine kinase inhibitor activity|positive regulation of cell growth|positive regulation of cell migration|dendrite|growth cone|cytoplasmic microtubule organization|small GTPase binding|vesicle|filopodium tip|ruffle membrane|positive regulation of cell adhesion mediated by integrin|thrombopoietin-mediated signaling pathway|regulation of cell population proliferation|sarcolemma|neuron projection|neuronal cell body|negative regulation of apoptotic process|positive regulation of catalytic activity|perikaryon|protein-membrane adaptor activity|ion channel binding|negative regulation of megakaryocyte differentiation|perinuclear region of cytoplasm|positive regulation of NF-kappaB transcription factor activity|cell division|regulation of cell division|negative regulation of protein kinase B signaling|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|positive regulation of calcineurin-NFAT signaling cascade|cellular response to tumor necrosis factor|cellular response to growth factor stimulus|negative regulation of protein serine/threonine kinase activity|positive regulation of protein serine/threonine kinase activity|cell periphery|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of protein targeting to membrane|extrinsic apoptotic signaling pathway|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of protein localization to plasma membrane|cellular response to nerve growth factor stimulus|positive regulation of male germ cell proliferation CIB2 86.91480255 73.86938567 99.96021942 1.353202257 0.436377489 0.380321169 1 1.570626831 2.089810488 10518 calcium and integrin binding family member 2 "GO:0000287,GO:0001750,GO:0001917,GO:0005509,GO:0005515,GO:0005737,GO:0007204,GO:0032420,GO:0032437,GO:0042383,GO:0042803,GO:0045494,GO:0055074,GO:0071318,GO:0072562" magnesium ion binding|photoreceptor outer segment|photoreceptor inner segment|calcium ion binding|protein binding|cytoplasm|positive regulation of cytosolic calcium ion concentration|stereocilium|cuticular plate|sarcolemma|protein homodimerization activity|photoreceptor cell maintenance|calcium ion homeostasis|cellular response to ATP|blood microparticle CIBAR1 736.9840511 751.1788233 722.7892789 0.962206676 -0.055581285 0.83182258 1 9.54955531 9.034886331 137392 CBY1 interacting BAR domain containing 1 "GO:0005515,GO:0005543,GO:0005634,GO:0005737,GO:0005743,GO:0005814,GO:0007007,GO:0035108,GO:0035869,GO:0036064,GO:0045880,GO:0060271,GO:0061024,GO:0097546" protein binding|phospholipid binding|nucleus|cytoplasm|mitochondrial inner membrane|centriole|inner mitochondrial membrane organization|limb morphogenesis|ciliary transition zone|ciliary basal body|positive regulation of smoothened signaling pathway|cilium assembly|membrane organization|ciliary base CIC 1047.618635 1096.596232 998.6410383 0.910673417 -0.134994323 0.583220216 1 6.75243169 6.046360503 23152 capicua transcriptional repressor "GO:0000785,GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007420,GO:0007612,GO:0007613,GO:0035176,GO:0043231,GO:0045892" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|brain development|learning|memory|social behavior|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated" hsa05017 Spinocerebellar ataxia CILK1 333.7023271 345.417409 321.9872453 0.93216855 -0.101337256 0.747024839 1 2.650509313 2.429377245 22858 ciliogenesis associated kinase 1 "GO:0000165,GO:0000287,GO:0001650,GO:0004672,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005929,GO:0006468,GO:0007165,GO:0007275,GO:0010468,GO:0035556,GO:0035720,GO:0035721,GO:0036064,GO:0042073,GO:0060271,GO:0097542,GO:0097546,GO:0106310,GO:0106311" MAPK cascade|magnesium ion binding|fibrillar center|protein kinase activity|protein serine/threonine kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|cilium|protein phosphorylation|signal transduction|multicellular organism development|regulation of gene expression|intracellular signal transduction|intraciliary anterograde transport|intraciliary retrograde transport|ciliary basal body|intraciliary transport|cilium assembly|ciliary tip|ciliary base|protein serine kinase activity|protein threonine kinase activity CILP2 41.51779009 30.1720026 52.86357758 1.752073877 0.809063608 0.210911362 1 0.383478048 0.660638838 148113 cartilage intermediate layer protein 2 "GO:0004035,GO:0004551,GO:0016311,GO:0070062" alkaline phosphatase activity|nucleotide diphosphatase activity|dephosphorylation|extracellular exosome CINP 455.5754048 428.6505196 482.5002899 1.12562628 0.170727917 0.545031789 1 24.004502 26.56795354 51550 cyclin dependent kinase 2 interacting protein "GO:0005515,GO:0005634,GO:0006260,GO:0006281,GO:0007049,GO:0051301" protein binding|nucleus|DNA replication|DNA repair|cell cycle|cell division CIP2A 1782.238811 1949.735616 1614.742006 0.82818511 -0.27197483 0.251496537 1 12.60952574 10.26827164 57650 cellular inhibitor of PP2A "GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0016021,GO:0042803,GO:0045296" protein binding|cytoplasm|cytosol|plasma membrane|integral component of membrane|protein homodimerization activity|cadherin binding CIPC 489.6662587 503.5603192 475.7721982 0.944816698 -0.081893632 0.771625145 1 6.213662134 5.772532328 85457 CLOCK interacting pacemaker "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0042754,GO:0045892,GO:0048511" "protein binding|nucleus|nucleoplasm|nucleolus|cytosol|negative regulation of circadian rhythm|negative regulation of transcription, DNA-templated|rhythmic process" CIR1 491.2124027 443.216314 539.2084913 1.216580875 0.28283223 0.303794705 1 12.33245051 14.75236147 9541 "corepressor interacting with RBPJ, CIR1" "GO:0000122,GO:0001701,GO:0003714,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0006397,GO:0008380,GO:0016607,GO:0019901,GO:0032991,GO:0042826,GO:0044877,GO:0045892" "negative regulation of transcription by RNA polymerase II|in utero embryonic development|transcription corepressor activity|protein binding|nucleus|cytoplasm|centrosome|mRNA processing|RNA splicing|nuclear speck|protein kinase binding|protein-containing complex|histone deacetylase binding|protein-containing complex binding|negative regulation of transcription, DNA-templated" "hsa04330,hsa05169" Notch signaling pathway|Epstein-Barr virus infection CIRBP 1718.055212 1816.562639 1619.547786 0.891545246 -0.165620077 0.486088318 1 40.31044048 35.3371981 1153 cold inducible RNA binding protein "GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0009409,GO:0009411,GO:0010494,GO:0017148,GO:0030371,GO:0034063,GO:0045727,GO:0048026,GO:0048255,GO:0070181" "RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|response to cold|response to UV|cytoplasmic stress granule|negative regulation of translation|translation repressor activity|stress granule assembly|positive regulation of translation|positive regulation of mRNA splicing, via spliceosome|mRNA stabilization|small ribosomal subunit rRNA binding" CISD1 517.4856756 439.0546585 595.9166927 1.357272224 0.440710107 0.104139824 1 9.865911652 13.16665215 55847 CDGSH iron sulfur domain 1 "GO:0005739,GO:0005741,GO:0016021,GO:0032473,GO:0042802,GO:0043457,GO:0046872,GO:0051537" "mitochondrion|mitochondrial outer membrane|integral component of membrane|cytoplasmic side of mitochondrial outer membrane|identical protein binding|regulation of cellular respiration|metal ion binding|2 iron, 2 sulfur cluster binding" CISD2 679.7065673 673.1477821 686.2653526 1.01948691 0.027843252 0.919819003 1 6.111714858 6.126549076 493856 CDGSH iron sulfur domain 2 "GO:0000422,GO:0003723,GO:0005515,GO:0005741,GO:0005783,GO:0005789,GO:0010259,GO:0010506,GO:0016020,GO:0016021,GO:0032991,GO:0042803,GO:0046872,GO:0051537,GO:0097038" "autophagy of mitochondrion|RNA binding|protein binding|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|multicellular organism aging|regulation of autophagy|membrane|integral component of membrane|protein-containing complex|protein homodimerization activity|metal ion binding|2 iron, 2 sulfur cluster binding|perinuclear endoplasmic reticulum" CISD3 329.3374964 344.3769952 314.2979976 0.912656775 -0.131855691 0.672884174 1 7.201711322 6.462705549 284106 CDGSH iron sulfur domain 3 "GO:0005739,GO:0046872,GO:0051537,GO:0106034" "mitochondrion|metal ion binding|2 iron, 2 sulfur cluster binding|protein maturation by [2Fe-2S] cluster transfer" CISH 16.41387876 14.56579436 18.26196316 1.253756762 0.326257481 0.777737653 1 0.351582847 0.433423191 1154 cytokine inducible SH2 containing protein "GO:0001558,GO:0003674,GO:0005515,GO:0005575,GO:0005829,GO:0005886,GO:0005942,GO:0007205,GO:0009968,GO:0016567,GO:0035556,GO:0038111,GO:0043551,GO:0043687,GO:0046854,GO:0046935" regulation of cell growth|molecular_function|protein binding|cellular_component|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|protein kinase C-activating G protein-coupled receptor signaling pathway|negative regulation of signal transduction|protein ubiquitination|intracellular signal transduction|interleukin-7-mediated signaling pathway|regulation of phosphatidylinositol 3-kinase activity|post-translational protein modification|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity "hsa04630,hsa04917" JAK-STAT signaling pathway|Prolactin signaling pathway CIT 2692.003221 2669.702023 2714.30442 1.016706882 0.023903808 0.921086435 1 14.27197138 14.26759943 11113 citron rho-interacting serine/threonine kinase "GO:0000278,GO:0000281,GO:0001223,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005856,GO:0016020,GO:0017124,GO:0018107,GO:0019901,GO:0030165,GO:0030291,GO:0031032,GO:0032467,GO:0035331,GO:0035556,GO:0046872,GO:0048699,GO:0051402,GO:0071901,GO:0097110,GO:0106310,GO:0106311" mitotic cell cycle|mitotic cytokinesis|transcription coactivator binding|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytosol|cytoskeleton|membrane|SH3 domain binding|peptidyl-threonine phosphorylation|protein kinase binding|PDZ domain binding|protein serine/threonine kinase inhibitor activity|actomyosin structure organization|positive regulation of cytokinesis|negative regulation of hippo signaling|intracellular signal transduction|metal ion binding|generation of neurons|neuron apoptotic process|negative regulation of protein serine/threonine kinase activity|scaffold protein binding|protein serine kinase activity|protein threonine kinase activity CITED1 6.524916457 7.282897178 5.766935736 0.791846376 -0.336707531 0.922510643 1 0.267498167 0.208272976 4435 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 "GO:0000578,GO:0001570,GO:0001656,GO:0001658,GO:0001890,GO:0003340,GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006913,GO:0006915,GO:0007179,GO:0007420,GO:0008022,GO:0010628,GO:0030178,GO:0030318,GO:0030511,GO:0032496,GO:0032868,GO:0034097,GO:0034341,GO:0042438,GO:0042803,GO:0042981,GO:0043473,GO:0043524,GO:0043627,GO:0045668,GO:0045892,GO:0045893,GO:0045944,GO:0050693,GO:0051591,GO:0060231,GO:0060395,GO:0060711,GO:0070410,GO:0070555,GO:0070669,GO:0070670,GO:0070741,GO:0071104,GO:0071105,GO:0071107,GO:0071559,GO:1902462" "embryonic axis specification|vasculogenesis|metanephros development|branching involved in ureteric bud morphogenesis|placenta development|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|chromatin binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|nucleocytoplasmic transport|apoptotic process|transforming growth factor beta receptor signaling pathway|brain development|protein C-terminus binding|positive regulation of gene expression|negative regulation of Wnt signaling pathway|melanocyte differentiation|positive regulation of transforming growth factor beta receptor signaling pathway|response to lipopolysaccharide|response to insulin|response to cytokine|response to interferon-gamma|melanin biosynthetic process|protein homodimerization activity|regulation of apoptotic process|pigmentation|negative regulation of neuron apoptotic process|response to estrogen|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|LBD domain binding|response to cAMP|mesenchymal to epithelial transition|SMAD protein signal transduction|labyrinthine layer development|co-SMAD binding|response to interleukin-1|response to interleukin-2|response to interleukin-4|response to interleukin-6|response to interleukin-9|response to interleukin-11|response to parathyroid hormone|response to transforming growth factor beta|positive regulation of mesenchymal stem cell proliferation" CITED2 1280.732324 1311.961906 1249.502743 0.952392548 -0.070371762 0.772761457 1 27.3183752 25.58244404 10370 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 "GO:0000122,GO:0000785,GO:0001666,GO:0001889,GO:0003151,GO:0003156,GO:0003682,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0007368,GO:0007507,GO:0007530,GO:0008283,GO:0010628,GO:0010629,GO:0019904,GO:0022409,GO:0030154,GO:0030336,GO:0030511,GO:0032991,GO:0034405,GO:0035035,GO:0035360,GO:0035802,GO:0043066,GO:0043627,GO:0045787,GO:0045892,GO:0045893,GO:0045944,GO:0048536,GO:0050693,GO:0060412,GO:0060971,GO:0060972,GO:0061428,GO:0070986,GO:1900164,GO:2000020" "negative regulation of transcription by RNA polymerase II|chromatin|response to hypoxia|liver development|outflow tract morphogenesis|regulation of animal organ formation|chromatin binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|determination of left/right symmetry|heart development|sex determination|cell population proliferation|positive regulation of gene expression|negative regulation of gene expression|protein domain specific binding|positive regulation of cell-cell adhesion|cell differentiation|negative regulation of cell migration|positive regulation of transforming growth factor beta receptor signaling pathway|protein-containing complex|response to fluid shear stress|histone acetyltransferase binding|positive regulation of peroxisome proliferator activated receptor signaling pathway|adrenal cortex formation|negative regulation of apoptotic process|response to estrogen|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|spleen development|LBD domain binding|ventricular septum morphogenesis|embryonic heart tube left/right pattern formation|left/right pattern formation|negative regulation of transcription from RNA polymerase II promoter in response to hypoxia|left/right axis specification|nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|positive regulation of male gonad development" hsa04137 Mitophagy - animal CITED4 422.1978722 372.46817 471.9275744 1.26702793 0.341448327 0.231559948 1 15.17400127 18.9041643 163732 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 "GO:0003713,GO:0005634,GO:0005654,GO:0005737,GO:0043627,GO:0045944" transcription coactivator activity|nucleus|nucleoplasm|cytoplasm|response to estrogen|positive regulation of transcription by RNA polymerase II CIZ1 2283.949087 2479.306282 2088.591892 0.842409793 -0.247405887 0.295333213 1 36.91853223 30.5801078 25792 CDKN1A interacting zinc finger protein 1 "GO:0003676,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0008270" nucleic acid binding|protein binding|nucleus|nucleoplasm|plasma membrane|zinc ion binding CKAP2 3523.412071 3641.448589 3405.375552 0.93517057 -0.096698567 0.684392407 1 50.37258126 46.31868442 26586 cytoskeleton associated protein 2 "GO:0000281,GO:0000922,GO:0005813,GO:0005829,GO:0005874,GO:0006915,GO:0015630,GO:0045944" mitotic cytokinesis|spindle pole|centrosome|cytosol|microtubule|apoptotic process|microtubule cytoskeleton|positive regulation of transcription by RNA polymerase II CKAP2L 3254.283987 3553.013409 2955.554565 0.831844472 -0.265614278 0.262477351 1 40.07985531 32.7823029 150468 cytoskeleton associated protein 2 like "GO:0000922,GO:0005813,GO:0005829,GO:0072686" spindle pole|centrosome|cytosol|mitotic spindle CKAP4 6075.109102 5857.530159 6292.688044 1.074290336 0.103383947 0.669967408 1 100.1620054 105.8024827 10970 cytoskeleton associated protein 4 "GO:0003723,GO:0005783,GO:0005788,GO:0005789,GO:0005791,GO:0005811,GO:0005829,GO:0005856,GO:0005886,GO:0016020,GO:0016021,GO:0016607,GO:0035577,GO:0035579,GO:0036464,GO:0042599,GO:0043312,GO:0043687,GO:0044267,GO:0048471,GO:0070062" RNA binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|rough endoplasmic reticulum|lipid droplet|cytosol|cytoskeleton|plasma membrane|membrane|integral component of membrane|nuclear speck|azurophil granule membrane|specific granule membrane|cytoplasmic ribonucleoprotein granule|lamellar body|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|perinuclear region of cytoplasm|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum CKAP5 10083.65978 10703.77802 9463.541543 0.88413096 -0.177668013 0.479950663 1 79.64876749 69.24155893 9793 cytoskeleton associated protein 5 "GO:0000086,GO:0000776,GO:0000777,GO:0000922,GO:0000930,GO:0005515,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0007019,GO:0007051,GO:0007052,GO:0007098,GO:0008017,GO:0010389,GO:0015630,GO:0016020,GO:0030951,GO:0032991,GO:0035371,GO:0043021,GO:0045296,GO:0046785,GO:0050658,GO:0051298,GO:0051301,GO:0061863,GO:0090063,GO:0097711" G2/M transition of mitotic cell cycle|kinetochore|condensed chromosome kinetochore|spindle pole|gamma-tubulin complex|protein binding|nucleolus|cytoplasm|centrosome|cytosol|plasma membrane|microtubule depolymerization|spindle organization|mitotic spindle organization|centrosome cycle|microtubule binding|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|membrane|establishment or maintenance of microtubule cytoskeleton polarity|protein-containing complex|microtubule plus-end|ribonucleoprotein complex binding|cadherin binding|microtubule polymerization|RNA transport|centrosome duplication|cell division|microtubule plus end polymerase|positive regulation of microtubule nucleation|ciliary basal body-plasma membrane docking CKB 259.3026737 221.608157 296.9971904 1.340190697 0.422438298 0.2023443 1 8.31118766 10.95218739 1152 creatine kinase B "GO:0004111,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005829,GO:0006600,GO:0016301,GO:0016310,GO:0021549,GO:0021762,GO:0030425,GO:0030644,GO:0031625,GO:0043025,GO:0046314,GO:0070062" creatine kinase activity|protein binding|ATP binding|extracellular space|nucleus|cytosol|creatine metabolic process|kinase activity|phosphorylation|cerebellum development|substantia nigra development|dendrite|cellular chloride ion homeostasis|ubiquitin protein ligase binding|neuronal cell body|phosphocreatine biosynthetic process|extracellular exosome hsa00330 Arginine and proline metabolism CKLF 27.10045075 30.1720026 24.0288989 0.796397217 -0.328439915 0.696427645 1 1.842361928 1.442699438 51192 chemokine like factor "GO:0005515,GO:0005576,GO:0005615,GO:0007165,GO:0008009,GO:0016020,GO:0016021,GO:0030593,GO:0032940,GO:0048246,GO:0048247" protein binding|extracellular region|extracellular space|signal transduction|chemokine activity|membrane|integral component of membrane|neutrophil chemotaxis|secretion by cell|macrophage chemotaxis|lymphocyte chemotaxis CKS1B 2984.292168 2924.603424 3043.980913 1.040818351 0.057718304 0.808503084 1 200.360346 205.0491118 1163 CDC28 protein kinase regulatory subunit 1B "GO:0000307,GO:0005515,GO:0005654,GO:0006355,GO:0007346,GO:0008283,GO:0019005,GO:0019901,GO:0042393,GO:0043130,GO:0044772,GO:0045737,GO:0051301,GO:0061575" "cyclin-dependent protein kinase holoenzyme complex|protein binding|nucleoplasm|regulation of transcription, DNA-templated|regulation of mitotic cell cycle|cell population proliferation|SCF ubiquitin ligase complex|protein kinase binding|histone binding|ubiquitin binding|mitotic cell cycle phase transition|positive regulation of cyclin-dependent protein serine/threonine kinase activity|cell division|cyclin-dependent protein serine/threonine kinase activator activity" "hsa05200,hsa05222" Pathways in cancer|Small cell lung cancer CKS2 1656.845015 1559.58041 1754.10962 1.12473176 0.169580971 0.476288703 1 135.1167859 149.4271259 1164 CDC28 protein kinase regulatory subunit 2 "GO:0000307,GO:0003682,GO:0005515,GO:0006357,GO:0007127,GO:0007346,GO:0008283,GO:0019005,GO:0019901,GO:0042393,GO:0043130,GO:0044772,GO:0045737,GO:0051301,GO:0061575" cyclin-dependent protein kinase holoenzyme complex|chromatin binding|protein binding|regulation of transcription by RNA polymerase II|meiosis I|regulation of mitotic cell cycle|cell population proliferation|SCF ubiquitin ligase complex|protein kinase binding|histone binding|ubiquitin binding|mitotic cell cycle phase transition|positive regulation of cyclin-dependent protein serine/threonine kinase activity|cell division|cyclin-dependent protein serine/threonine kinase activator activity "hsa05200,hsa05222" Pathways in cancer|Small cell lung cancer CLASP1 1279.785645 1375.427153 1184.144138 0.860928283 -0.216035031 0.370382034 1 5.927327133 5.017611721 23332 cytoplasmic linker associated protein 1 "GO:0000086,GO:0000226,GO:0000776,GO:0000777,GO:0001578,GO:0002162,GO:0005515,GO:0005794,GO:0005813,GO:0005815,GO:0005828,GO:0005829,GO:0005876,GO:0005881,GO:0005925,GO:0005938,GO:0006903,GO:0007020,GO:0007026,GO:0007030,GO:0007052,GO:0007163,GO:0008017,GO:0010389,GO:0010458,GO:0010470,GO:0010634,GO:0010717,GO:0016020,GO:0030953,GO:0030981,GO:0031023,GO:0031110,GO:0031111,GO:0031116,GO:0031592,GO:0034453,GO:0035371,GO:0040001,GO:0043515,GO:0045180,GO:0045921,GO:0051010,GO:0051294,GO:0051301,GO:0051497,GO:0051893,GO:0070507,GO:0072686,GO:0090091,GO:0090162,GO:0090307,GO:0097711,GO:1903690,GO:1904261" "G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|kinetochore|condensed chromosome kinetochore|microtubule bundle formation|dystroglycan binding|protein binding|Golgi apparatus|centrosome|microtubule organizing center|kinetochore microtubule|cytosol|spindle microtubule|cytoplasmic microtubule|focal adhesion|cell cortex|vesicle targeting|microtubule nucleation|negative regulation of microtubule depolymerization|Golgi organization|mitotic spindle organization|establishment or maintenance of cell polarity|microtubule binding|regulation of G2/M transition of mitotic cell cycle|exit from mitosis|regulation of gastrulation|positive regulation of epithelial cell migration|regulation of epithelial to mesenchymal transition|membrane|astral microtubule organization|cortical microtubule cytoskeleton|microtubule organizing center organization|regulation of microtubule polymerization or depolymerization|negative regulation of microtubule polymerization or depolymerization|positive regulation of microtubule polymerization|centrosomal corona|microtubule anchoring|microtubule plus-end|establishment of mitotic spindle localization|kinetochore binding|basal cortex|positive regulation of exocytosis|microtubule plus-end binding|establishment of spindle orientation|cell division|negative regulation of stress fiber assembly|regulation of focal adhesion assembly|regulation of microtubule cytoskeleton organization|mitotic spindle|positive regulation of extracellular matrix disassembly|establishment of epithelial cell polarity|mitotic spindle assembly|ciliary basal body-plasma membrane docking|negative regulation of wound healing, spreading of epidermal cells|positive regulation of basement membrane assembly involved in embryonic body morphogenesis" CLASP2 1346.392255 1458.660263 1234.124247 0.846066955 -0.241156257 0.315433181 1 10.24020223 8.518918142 23122 cytoplasmic linker associated protein 2 "GO:0000226,GO:0000776,GO:0000777,GO:0002162,GO:0005515,GO:0005737,GO:0005794,GO:0005802,GO:0005815,GO:0005828,GO:0005829,GO:0005874,GO:0005876,GO:0005881,GO:0005886,GO:0005925,GO:0005938,GO:0006903,GO:0007020,GO:0007026,GO:0007030,GO:0007052,GO:0007163,GO:0008017,GO:0010458,GO:0010470,GO:0010634,GO:0010717,GO:0016020,GO:0031023,GO:0031110,GO:0031252,GO:0032587,GO:0032886,GO:0034453,GO:0040001,GO:0045180,GO:0045921,GO:0051010,GO:0051301,GO:0051497,GO:0051895,GO:0072659,GO:0072686,GO:0090091,GO:0090307,GO:1903690,GO:1904261" "microtubule cytoskeleton organization|kinetochore|condensed chromosome kinetochore|dystroglycan binding|protein binding|cytoplasm|Golgi apparatus|trans-Golgi network|microtubule organizing center|kinetochore microtubule|cytosol|microtubule|spindle microtubule|cytoplasmic microtubule|plasma membrane|focal adhesion|cell cortex|vesicle targeting|microtubule nucleation|negative regulation of microtubule depolymerization|Golgi organization|mitotic spindle organization|establishment or maintenance of cell polarity|microtubule binding|exit from mitosis|regulation of gastrulation|positive regulation of epithelial cell migration|regulation of epithelial to mesenchymal transition|membrane|microtubule organizing center organization|regulation of microtubule polymerization or depolymerization|cell leading edge|ruffle membrane|regulation of microtubule-based process|microtubule anchoring|establishment of mitotic spindle localization|basal cortex|positive regulation of exocytosis|microtubule plus-end binding|cell division|negative regulation of stress fiber assembly|negative regulation of focal adhesion assembly|protein localization to plasma membrane|mitotic spindle|positive regulation of extracellular matrix disassembly|mitotic spindle assembly|negative regulation of wound healing, spreading of epidermal cells|positive regulation of basement membrane assembly involved in embryonic body morphogenesis" CLASRP 475.8584451 481.7116277 470.0052625 0.975698396 -0.035492838 0.905624302 1 11.22132877 10.76542195 11129 CLK4 associating serine/arginine rich protein "GO:0005515,GO:0005654,GO:0006397,GO:0008380" protein binding|nucleoplasm|mRNA processing|RNA splicing CLBA1 180.3048317 178.9511878 181.6584757 1.015128639 0.02166256 0.9707121 1 1.970758563 1.96709657 122616 clathrin binding box of aftiphilin containing 1 "GO:0030121,GO:0030276,GO:0032588,GO:0046907" AP-1 adaptor complex|clathrin binding|trans-Golgi network membrane|intracellular transport CLCC1 668.603584 697.0773014 640.1298667 0.918305424 -0.122954028 0.637141148 1 7.195693308 6.497270869 23155 chloride channel CLIC like 1 "GO:0000139,GO:0005254,GO:0005515,GO:0005783,GO:0005789,GO:0016020,GO:0031965,GO:0034707,GO:0043231,GO:0044233,GO:1902476" Golgi membrane|chloride channel activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|membrane|nuclear membrane|chloride channel complex|intracellular membrane-bounded organelle|mitochondria-associated endoplasmic reticulum membrane|chloride transmembrane transport CLCF1 272.9073121 250.7397457 295.0748785 1.176817332 0.234890399 0.47455087 1 7.288409253 8.433599736 23529 cardiotrophin like cytokine factor 1 "GO:0002639,GO:0005102,GO:0005125,GO:0005127,GO:0005515,GO:0005576,GO:0007166,GO:0007259,GO:0008083,GO:0008284,GO:0019221,GO:0030183,GO:0030890,GO:0042531,GO:0043524,GO:0048295,GO:0048711,GO:0097058,GO:0097059" positive regulation of immunoglobulin production|signaling receptor binding|cytokine activity|ciliary neurotrophic factor receptor binding|protein binding|extracellular region|cell surface receptor signaling pathway|receptor signaling pathway via JAK-STAT|growth factor activity|positive regulation of cell population proliferation|cytokine-mediated signaling pathway|B cell differentiation|positive regulation of B cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of neuron apoptotic process|positive regulation of isotype switching to IgE isotypes|positive regulation of astrocyte differentiation|CRLF-CLCF1 complex|CNTFR-CLCF1 complex hsa04060 Cytokine-cytokine receptor interaction CLCN2 117.4088673 130.0517353 104.7659992 0.805571713 -0.31191507 0.487733902 1 1.614849253 1.279108466 1181 chloride voltage-gated channel 2 "GO:0005247,GO:0005886,GO:0005887,GO:0006821,GO:0032347,GO:0034220,GO:0034707,GO:0034765,GO:0060041,GO:0060689,GO:1902476" voltage-gated chloride channel activity|plasma membrane|integral component of plasma membrane|chloride transport|regulation of aldosterone biosynthetic process|ion transmembrane transport|chloride channel complex|regulation of ion transmembrane transport|retina development in camera-type eye|cell differentiation involved in salivary gland development|chloride transmembrane transport hsa04978 Mineral absorption CLCN3 1060.415603 1142.374443 978.4567632 0.856511426 -0.223455603 0.361454968 1 12.05108212 10.14916669 1182 chloride voltage-gated channel 3 "GO:0000139,GO:0005247,GO:0005254,GO:0005515,GO:0005524,GO:0005765,GO:0005769,GO:0005770,GO:0005794,GO:0005886,GO:0005887,GO:0006885,GO:0006911,GO:0008021,GO:0008344,GO:0009897,GO:0009986,GO:0010008,GO:0012506,GO:0015297,GO:0015299,GO:0016020,GO:0016021,GO:0030141,GO:0030165,GO:0031410,GO:0031901,GO:0031902,GO:0032587,GO:0035249,GO:0042581,GO:0043231,GO:0043679,GO:0045335,GO:0045494,GO:0045794,GO:0048388,GO:0051932,GO:0055037,GO:0072320,GO:0097401,GO:0098978,GO:1902476,GO:1903428" "Golgi membrane|voltage-gated chloride channel activity|chloride channel activity|protein binding|ATP binding|lysosomal membrane|early endosome|late endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|regulation of pH|phagocytosis, engulfment|synaptic vesicle|adult locomotory behavior|external side of plasma membrane|cell surface|endosome membrane|vesicle membrane|antiporter activity|solute:proton antiporter activity|membrane|integral component of membrane|secretory granule|PDZ domain binding|cytoplasmic vesicle|early endosome membrane|late endosome membrane|ruffle membrane|synaptic transmission, glutamatergic|specific granule|intracellular membrane-bounded organelle|axon terminus|phagocytic vesicle|photoreceptor cell maintenance|negative regulation of cell volume|endosomal lumen acidification|synaptic transmission, GABAergic|recycling endosome|volume-sensitive chloride channel activity|synaptic vesicle lumen acidification|glutamatergic synapse|chloride transmembrane transport|positive regulation of reactive oxygen species biosynthetic process" CLCN4 312.2644021 375.5894116 248.9393926 0.66279662 -0.593361849 0.055995781 1 2.965603876 1.932700702 1183 chloride voltage-gated channel 4 "GO:0005247,GO:0005254,GO:0005515,GO:0005524,GO:0005765,GO:0005769,GO:0005789,GO:0005794,GO:0005887,GO:0006821,GO:0008021,GO:0010008,GO:0015297,GO:0015299,GO:0031901,GO:0031902,GO:0034220,GO:0055037,GO:0055038,GO:1902476,GO:1902600" voltage-gated chloride channel activity|chloride channel activity|protein binding|ATP binding|lysosomal membrane|early endosome|endoplasmic reticulum membrane|Golgi apparatus|integral component of plasma membrane|chloride transport|synaptic vesicle|endosome membrane|antiporter activity|solute:proton antiporter activity|early endosome membrane|late endosome membrane|ion transmembrane transport|recycling endosome|recycling endosome membrane|chloride transmembrane transport|proton transmembrane transport CLCN5 303.1730495 376.6298255 229.7162735 0.609925869 -0.713294189 0.022913833 0.835591117 1.952977222 1.17123869 1184 chloride voltage-gated channel 5 "GO:0000139,GO:0005247,GO:0005254,GO:0005515,GO:0005524,GO:0005765,GO:0005769,GO:0005794,GO:0005829,GO:0005886,GO:0005887,GO:0006897,GO:0007588,GO:0008021,GO:0010008,GO:0015299,GO:0016020,GO:0034220,GO:0042802,GO:0045177,GO:1902476,GO:1902600" Golgi membrane|voltage-gated chloride channel activity|chloride channel activity|protein binding|ATP binding|lysosomal membrane|early endosome|Golgi apparatus|cytosol|plasma membrane|integral component of plasma membrane|endocytosis|excretion|synaptic vesicle|endosome membrane|solute:proton antiporter activity|membrane|ion transmembrane transport|identical protein binding|apical part of cell|chloride transmembrane transport|proton transmembrane transport CLCN6 526.1996315 579.5105326 472.8887303 0.816014039 -0.293334122 0.278134528 1 5.533621763 4.439952049 1185 chloride voltage-gated channel 6 "GO:0005247,GO:0005524,GO:0005765,GO:0006821,GO:0006884,GO:0007165,GO:0009612,GO:0010008,GO:0015108,GO:0015297,GO:0016021,GO:0034220,GO:0043231,GO:1902476" voltage-gated chloride channel activity|ATP binding|lysosomal membrane|chloride transport|cell volume homeostasis|signal transduction|response to mechanical stimulus|endosome membrane|chloride transmembrane transporter activity|antiporter activity|integral component of membrane|ion transmembrane transport|intracellular membrane-bounded organelle|chloride transmembrane transport CLCN7 558.6210385 623.2079157 494.0341614 0.792727674 -0.335102754 0.209079525 1 7.389349268 5.759720283 1186 chloride voltage-gated channel 7 "GO:0005247,GO:0005254,GO:0005515,GO:0005524,GO:0005654,GO:0005765,GO:0015108,GO:0015297,GO:0016020,GO:0016021,GO:0034220,GO:0043231,GO:1902476" voltage-gated chloride channel activity|chloride channel activity|protein binding|ATP binding|nucleoplasm|lysosomal membrane|chloride transmembrane transporter activity|antiporter activity|membrane|integral component of membrane|ion transmembrane transport|intracellular membrane-bounded organelle|chloride transmembrane transport CLCNKB 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.037797806 0.051501129 1188 chloride voltage-gated channel Kb "GO:0005247,GO:0005886,GO:0005887,GO:0006821,GO:0007588,GO:0034220,GO:0034707,GO:0034765,GO:0046872,GO:1902476" voltage-gated chloride channel activity|plasma membrane|integral component of plasma membrane|chloride transport|excretion|ion transmembrane transport|chloride channel complex|regulation of ion transmembrane transport|metal ion binding|chloride transmembrane transport hsa04966 Collecting duct acid secretion CLDN1 8556.968572 10542.51387 6571.423271 0.623326026 -0.681941145 0.006150546 0.469832129 163.2717902 100.0685469 9076 claudin 1 "GO:0001618,GO:0005198,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0005923,GO:0007155,GO:0007568,GO:0008065,GO:0009636,GO:0016021,GO:0016323,GO:0016324,GO:0016328,GO:0016338,GO:0030335,GO:0032496,GO:0032991,GO:0034331,GO:0035633,GO:0042538,GO:0042802,GO:0045216,GO:0045471,GO:0046718,GO:0051259,GO:0060054,GO:0061436,GO:0061772,GO:0070160,GO:0070673,GO:0070830,GO:0071284,GO:0071346,GO:0071356,GO:0071548,GO:0071560,GO:0090303,GO:0090557,GO:0097421,GO:1903348,GO:1903545" virus receptor activity|structural molecule activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|bicellular tight junction|cell adhesion|aging|establishment of blood-nerve barrier|response to toxic substance|integral component of membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|positive regulation of cell migration|response to lipopolysaccharide|protein-containing complex|cell junction maintenance|maintenance of blood-brain barrier|hyperosmotic salinity response|identical protein binding|cell-cell junction organization|response to ethanol|viral entry into host cell|protein complex oligomerization|positive regulation of epithelial cell proliferation involved in wound healing|establishment of skin barrier|xenobiotic transport across blood-nerve barrier|tight junction|response to interleukin-18|bicellular tight junction assembly|cellular response to lead ion|cellular response to interferon-gamma|cellular response to tumor necrosis factor|response to dexamethasone|cellular response to transforming growth factor beta stimulus|positive regulation of wound healing|establishment of endothelial intestinal barrier|liver regeneration|positive regulation of bicellular tight junction assembly|cellular response to butyrate "hsa04514,hsa04530,hsa04670,hsa05130,hsa05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C CLDN11 5578.182756 6475.536006 4680.829506 0.722848194 -0.468235398 0.052567954 1 120.4137474 85.58434892 5010 claudin 11 "GO:0005198,GO:0005515,GO:0005811,GO:0005883,GO:0005886,GO:0005923,GO:0007155,GO:0007283,GO:0008366,GO:0016021,GO:0016338,GO:0030054,GO:0030424,GO:0042802,GO:0045178,GO:0070160,GO:0070830,GO:0120192" structural molecule activity|protein binding|lipid droplet|neurofilament|plasma membrane|bicellular tight junction|cell adhesion|spermatogenesis|axon ensheathment|integral component of membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|cell junction|axon|identical protein binding|basal part of cell|tight junction|bicellular tight junction assembly|tight junction assembly "hsa04514,hsa04530,hsa04670,hsa05130,hsa05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C CLDN12 2640.642357 2418.962277 2862.322437 1.183285272 0.242797928 0.304617321 1 36.53992948 42.51364509 9069 claudin 12 "GO:0005515,GO:0005886,GO:0005923,GO:0016021,GO:0016328,GO:0016338,GO:0035633,GO:0042802,GO:0120192" protein binding|plasma membrane|bicellular tight junction|integral component of membrane|lateral plasma membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|maintenance of blood-brain barrier|identical protein binding|tight junction assembly CLDN14 4.122026567 7.282897178 0.961155956 0.131974396 -2.921670032 0.166282975 1 0.149951712 0.019458631 23562 claudin 14 "GO:0005198,GO:0005515,GO:0005783,GO:0005886,GO:0005923,GO:0007155,GO:0016021,GO:0016338,GO:0042802,GO:0065003,GO:0070830" structural molecule activity|protein binding|endoplasmic reticulum|plasma membrane|bicellular tight junction|cell adhesion|integral component of membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|identical protein binding|protein-containing complex assembly|bicellular tight junction assembly "hsa04514,hsa04530,hsa04670,hsa05130,hsa05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C CLDN15 142.0271702 158.1429102 125.9114302 0.796187639 -0.328819622 0.431672676 1 4.0055987 3.135841091 24146 claudin 15 "GO:0005198,GO:0005886,GO:0005923,GO:0006811,GO:0007155,GO:0016021,GO:0016328,GO:0016338,GO:0042802,GO:0070830" structural molecule activity|plasma membrane|bicellular tight junction|ion transport|cell adhesion|integral component of membrane|lateral plasma membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|identical protein binding|bicellular tight junction assembly "hsa04514,hsa04530,hsa04670,hsa05130,hsa05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C CLDN16 29.5429696 31.21241648 27.87352272 0.893026746 -0.16322471 0.867037103 1 0.467907107 0.410861348 10686 claudin 16 "GO:0005198,GO:0005515,GO:0005886,GO:0005923,GO:0006875,GO:0007155,GO:0007588,GO:0015095,GO:0016021,GO:0016338,GO:0042802,GO:0070830,GO:1903830" structural molecule activity|protein binding|plasma membrane|bicellular tight junction|cellular metal ion homeostasis|cell adhesion|excretion|magnesium ion transmembrane transporter activity|integral component of membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|identical protein binding|bicellular tight junction assembly|magnesium ion transmembrane transport "hsa04514,hsa04530,hsa04670,hsa05130,hsa05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C CLDN23 35.70619497 41.61655531 29.79583464 0.715961098 -0.482046894 0.492813047 1 1.02824031 0.723861085 137075 claudin 23 "GO:0005198,GO:0005515,GO:0005886,GO:0005923,GO:0007155,GO:0016021,GO:0016338,GO:0042802,GO:0070830" structural molecule activity|protein binding|plasma membrane|bicellular tight junction|cell adhesion|integral component of membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|identical protein binding|bicellular tight junction assembly "hsa04514,hsa04530,hsa04670,hsa05130,hsa05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C CLDN4 17.25111741 23.9295193 10.57271552 0.441827326 -1.178445447 0.197274979 1 0.753436262 0.327318287 1364 claudin 4 "GO:0004888,GO:0005198,GO:0005254,GO:0005515,GO:0005886,GO:0005887,GO:0005911,GO:0005923,GO:0007155,GO:0007565,GO:0007623,GO:0009925,GO:0016324,GO:0016327,GO:0016328,GO:0016338,GO:0022604,GO:0030335,GO:0032570,GO:0034707,GO:0042802,GO:0061436,GO:0070160,GO:0070293,GO:0070830,GO:0090303,GO:1902476,GO:1905050" transmembrane signaling receptor activity|structural molecule activity|chloride channel activity|protein binding|plasma membrane|integral component of plasma membrane|cell-cell junction|bicellular tight junction|cell adhesion|female pregnancy|circadian rhythm|basal plasma membrane|apical plasma membrane|apicolateral plasma membrane|lateral plasma membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|regulation of cell morphogenesis|positive regulation of cell migration|response to progesterone|chloride channel complex|identical protein binding|establishment of skin barrier|tight junction|renal absorption|bicellular tight junction assembly|positive regulation of wound healing|chloride transmembrane transport|positive regulation of metallopeptidase activity "hsa04514,hsa04530,hsa04670,hsa05130,hsa05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C CLDN7 11.04826308 12.48496659 9.61155956 0.769850643 -0.377349516 0.799003187 1 0.417219612 0.315821993 1366 claudin 7 "GO:0005198,GO:0005515,GO:0005886,GO:0005923,GO:0007155,GO:0007162,GO:0008284,GO:0016021,GO:0016323,GO:0016327,GO:0016328,GO:0016338,GO:0019904,GO:0031333,GO:0042802,GO:0043066,GO:0045471,GO:0050839,GO:0070830,GO:2000147" structural molecule activity|protein binding|plasma membrane|bicellular tight junction|cell adhesion|negative regulation of cell adhesion|positive regulation of cell population proliferation|integral component of membrane|basolateral plasma membrane|apicolateral plasma membrane|lateral plasma membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|protein domain specific binding|negative regulation of protein-containing complex assembly|identical protein binding|negative regulation of apoptotic process|response to ethanol|cell adhesion molecule binding|bicellular tight junction assembly|positive regulation of cell motility "hsa04514,hsa04530,hsa04670,hsa05130,hsa05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C CLDN9 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.105227372 0 9080 claudin 9 "GO:0001618,GO:0005198,GO:0005515,GO:0005886,GO:0005923,GO:0007155,GO:0016021,GO:0016338,GO:0030054,GO:0042802,GO:0043231,GO:0046718,GO:0070830" virus receptor activity|structural molecule activity|protein binding|plasma membrane|bicellular tight junction|cell adhesion|integral component of membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|cell junction|identical protein binding|intracellular membrane-bounded organelle|viral entry into host cell|bicellular tight junction assembly "hsa04514,hsa04530,hsa04670,hsa05130,hsa05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C CLDND1 2724.09815 2629.125881 2819.070419 1.07224627 0.100636297 0.671323581 1 59.25321629 62.47088401 56650 claudin domain containing 1 "GO:0005515,GO:0009986,GO:0016021" protein binding|cell surface|integral component of membrane CLDND2 10.40916924 8.323311061 12.49502743 1.501208754 0.586124608 0.656643747 1 0.238560587 0.352136434 125875 claudin domain containing 2 "GO:0005515,GO:0005886,GO:0016021" protein binding|plasma membrane|integral component of membrane CLEC11A 812.0189967 689.7944042 934.2435892 1.354379774 0.437632334 0.081489316 1 26.77313423 35.6542129 6320 C-type lectin domain containing 11A "GO:0001503,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0007165,GO:0008083,GO:0008284,GO:0030246" ossification|protein binding|extracellular region|extracellular space|cytoplasm|signal transduction|growth factor activity|positive regulation of cell population proliferation|carbohydrate binding CLEC12B 5.405244648 3.121241648 7.689247648 2.463522058 1.300722389 0.455625732 1 0.044125809 0.106885875 387837 C-type lectin domain family 12 member B "GO:0002769,GO:0009897,GO:0016021,GO:0019903,GO:0030246,GO:0030547,GO:0032991,GO:0045953,GO:2000272" natural killer cell inhibitory signaling pathway|external side of plasma membrane|integral component of membrane|protein phosphatase binding|carbohydrate binding|receptor inhibitor activity|protein-containing complex|negative regulation of natural killer cell mediated cytotoxicity|negative regulation of signaling receptor activity CLEC16A 600.3816328 647.137435 553.6258307 0.855499621 -0.225160879 0.393177952 1 2.619182126 2.203214082 23274 C-type lectin domain containing 16A "GO:0003674,GO:0005770,GO:0005794,GO:0005829,GO:0006914,GO:0008333,GO:0009267,GO:0016021,GO:0016197,GO:0031982,GO:0036020,GO:1901096,GO:1901097,GO:1904263,GO:1904766" molecular_function|late endosome|Golgi apparatus|cytosol|autophagy|endosome to lysosome transport|cellular response to starvation|integral component of membrane|endosomal transport|vesicle|endolysosome membrane|regulation of autophagosome maturation|negative regulation of autophagosome maturation|positive regulation of TORC1 signaling|negative regulation of macroautophagy by TORC1 signaling CLEC18A 11.52884105 12.48496659 10.57271552 0.846835707 -0.239845992 0.903809209 1 0.128307283 0.106836991 348174 C-type lectin domain family 18 member A "GO:0005515,GO:0005615,GO:0005768,GO:0005783,GO:0005794,GO:0030247" protein binding|extracellular space|endosome|endoplasmic reticulum|Golgi apparatus|polysaccharide binding CLEC2B 728.1807764 633.6120545 822.7494983 1.298506701 0.376853459 0.139118751 1 22.05786746 28.16299879 9976 C-type lectin domain family 2 member B "GO:0005515,GO:0005886,GO:0005887,GO:0009897,GO:0030246,GO:0042802,GO:0050776" protein binding|plasma membrane|integral component of plasma membrane|external side of plasma membrane|carbohydrate binding|identical protein binding|regulation of immune response hsa05167 Kaposi sarcoma-associated herpesvirus infection CLEC2D 96.31815645 93.63724944 98.99906347 1.05726155 0.080332321 0.887296432 1 0.932496343 0.969394953 29121 C-type lectin domain family 2 member D "GO:0004888,GO:0005783,GO:0005886,GO:0005887,GO:0007166,GO:0009897,GO:0009986,GO:0016020,GO:0030246,GO:0046703,GO:0050776" transmembrane signaling receptor activity|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|external side of plasma membrane|cell surface|membrane|carbohydrate binding|natural killer cell lectin-like receptor binding|regulation of immune response CLEC4A 6.926236509 5.202069413 8.650403604 1.662877389 0.733681797 0.660649523 1 0.082356833 0.134657654 50856 C-type lectin domain family 4 member A "GO:0001818,GO:0002223,GO:0002250,GO:0002470,GO:0004888,GO:0005509,GO:0005537,GO:0005886,GO:0005887,GO:0007155,GO:0007166,GO:0016032,GO:0030246,GO:0032720,GO:0036037,GO:0042590,GO:0045087" "negative regulation of cytokine production|stimulatory C-type lectin receptor signaling pathway|adaptive immune response|plasmacytoid dendritic cell antigen processing and presentation|transmembrane signaling receptor activity|calcium ion binding|mannose binding|plasma membrane|integral component of plasma membrane|cell adhesion|cell surface receptor signaling pathway|viral process|carbohydrate binding|negative regulation of tumor necrosis factor production|CD8-positive, alpha-beta T cell activation|antigen processing and presentation of exogenous peptide antigen via MHC class I|innate immune response" CLEC4F 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.0441653 165530 C-type lectin domain family 4 member F "GO:0006897,GO:0016021,GO:0030246" endocytosis|integral component of membrane|carbohydrate binding CLEC5A 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.047579243 0.028812781 23601 C-type lectin domain containing 5A "GO:0001618,GO:0002076,GO:0005829,GO:0005886,GO:0005887,GO:0006968,GO:0007165,GO:0009986,GO:0030246,GO:0035579,GO:0043066,GO:0043312,GO:0045087,GO:0046718,GO:0070821" virus receptor activity|osteoblast development|cytosol|plasma membrane|integral component of plasma membrane|cellular defense response|signal transduction|cell surface|carbohydrate binding|specific granule membrane|negative regulation of apoptotic process|neutrophil degranulation|innate immune response|viral entry into host cell|tertiary granule membrane CLGN 1927.431882 2102.676457 1752.187308 0.833312849 -0.26306987 0.266566983 1 39.94872835 32.73272909 1047 calmegin "GO:0005509,GO:0005635,GO:0005783,GO:0005789,GO:0006457,GO:0007338,GO:0007339,GO:0016021,GO:0030968,GO:0044183,GO:0051082,GO:0065003" calcium ion binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|protein folding|single fertilization|binding of sperm to zona pellucida|integral component of membrane|endoplasmic reticulum unfolded protein response|protein folding chaperone|unfolded protein binding|protein-containing complex assembly CLHC1 95.83757847 93.63724944 98.03790751 1.046996875 0.066257136 0.911753454 1 0.901216935 0.927781926 130162 clathrin heavy chain linker domain containing 1 GO:0005515 protein binding CLIC1 8414.315709 7365.089875 9463.541543 1.284918678 0.361677054 0.14444347 1 225.8973047 285.4025636 1192 chloride intracellular channel 1 "GO:0005244,GO:0005254,GO:0005515,GO:0005615,GO:0005634,GO:0005635,GO:0005737,GO:0005739,GO:0005886,GO:0005903,GO:0006749,GO:0006821,GO:0007165,GO:0016020,GO:0031965,GO:0031982,GO:0034707,GO:0034765,GO:0045296,GO:0045669,GO:0048471,GO:0051726,GO:0051881,GO:0070062,GO:0070527,GO:0072562,GO:1902476" voltage-gated ion channel activity|chloride channel activity|protein binding|extracellular space|nucleus|nuclear envelope|cytoplasm|mitochondrion|plasma membrane|brush border|glutathione metabolic process|chloride transport|signal transduction|membrane|nuclear membrane|vesicle|chloride channel complex|regulation of ion transmembrane transport|cadherin binding|positive regulation of osteoblast differentiation|perinuclear region of cytoplasm|regulation of cell cycle|regulation of mitochondrial membrane potential|extracellular exosome|platelet aggregation|blood microparticle|chloride transmembrane transport CLIC2 20.61516325 23.9295193 17.30080721 0.722990169 -0.467952065 0.608529082 1 0.486875511 0.346115861 1193 chloride intracellular channel 2 "GO:0004364,GO:0004602,GO:0005244,GO:0005254,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006749,GO:0007165,GO:0010880,GO:0010881,GO:0034707,GO:0051099,GO:0060315,GO:0098869,GO:1902476" glutathione transferase activity|glutathione peroxidase activity|voltage-gated ion channel activity|chloride channel activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|glutathione metabolic process|signal transduction|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|chloride channel complex|positive regulation of binding|negative regulation of ryanodine-sensitive calcium-release channel activity|cellular oxidant detoxification|chloride transmembrane transport CLIC3 14.333051 10.40413883 18.26196316 1.755259466 0.811684309 0.429148346 1 0.425152961 0.733766214 9022 chloride intracellular channel 3 "GO:0005244,GO:0005254,GO:0005515,GO:0005634,GO:0005737,GO:0006749,GO:0006821,GO:0007165,GO:0016604,GO:0034707,GO:0034765,GO:0070062,GO:1902476" voltage-gated ion channel activity|chloride channel activity|protein binding|nucleus|cytoplasm|glutathione metabolic process|chloride transport|signal transduction|nuclear body|chloride channel complex|regulation of ion transmembrane transport|extracellular exosome|chloride transmembrane transport CLIC4 14304.5489 13554.51206 15054.58574 1.110669692 0.15142983 0.561865607 1 170.0868556 185.7491572 25932 chloride intracellular channel 4 "GO:0001525,GO:0001886,GO:0005244,GO:0005254,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005813,GO:0005829,GO:0005886,GO:0005902,GO:0005911,GO:0006821,GO:0007035,GO:0009566,GO:0009986,GO:0015629,GO:0015630,GO:0016363,GO:0030154,GO:0030216,GO:0030336,GO:0030496,GO:0030659,GO:0034707,GO:0034765,GO:0035088,GO:0035264,GO:0045177,GO:0048471,GO:0048754,GO:0051493,GO:0061299,GO:0070062,GO:0071277,GO:1902476" angiogenesis|endothelial cell morphogenesis|voltage-gated ion channel activity|chloride channel activity|protein binding|nucleus|cytoplasm|mitochondrion|centrosome|cytosol|plasma membrane|microvillus|cell-cell junction|chloride transport|vacuolar acidification|fertilization|cell surface|actin cytoskeleton|microtubule cytoskeleton|nuclear matrix|cell differentiation|keratinocyte differentiation|negative regulation of cell migration|midbody|cytoplasmic vesicle membrane|chloride channel complex|regulation of ion transmembrane transport|establishment or maintenance of apical/basal cell polarity|multicellular organism growth|apical part of cell|perinuclear region of cytoplasm|branching morphogenesis of an epithelial tube|regulation of cytoskeleton organization|retina vasculature morphogenesis in camera-type eye|extracellular exosome|cellular response to calcium ion|chloride transmembrane transport CLINT1 2919.864537 2999.513224 2840.21585 0.946892258 -0.078727816 0.740346189 1 39.28306942 36.57439566 9685 clathrin interactor 1 "GO:0005515,GO:0005543,GO:0005654,GO:0005768,GO:0005794,GO:0005829,GO:0005886,GO:0006897,GO:0016020,GO:0030125,GO:0030276,GO:0043231,GO:0045296,GO:0048268,GO:0048471" protein binding|phospholipid binding|nucleoplasm|endosome|Golgi apparatus|cytosol|plasma membrane|endocytosis|membrane|clathrin vesicle coat|clathrin binding|intracellular membrane-bounded organelle|cadherin binding|clathrin coat assembly|perinuclear region of cytoplasm CLIP1 2402.423521 2549.014012 2255.833029 0.884982592 -0.176279017 0.456162877 1 15.39219201 13.39387924 6249 CAP-Gly domain containing linker protein 1 "GO:0000278,GO:0000776,GO:0001578,GO:0001726,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0005874,GO:0005882,GO:0008017,GO:0008270,GO:0015630,GO:0015631,GO:0030659,GO:0031116,GO:0031122,GO:0035371,GO:0044354,GO:0051010" mitotic cell cycle|kinetochore|microtubule bundle formation|ruffle|protein binding|nucleus|cytoplasm|centrosome|cytosol|microtubule|intermediate filament|microtubule binding|zinc ion binding|microtubule cytoskeleton|tubulin binding|cytoplasmic vesicle membrane|positive regulation of microtubule polymerization|cytoplasmic microtubule organization|microtubule plus-end|macropinosome|microtubule plus-end binding hsa04150 mTOR signaling pathway CLIP2 3763.208578 3969.178962 3557.238193 0.896215118 -0.158083031 0.506361631 1 37.67166747 33.19695794 7461 CAP-Gly domain containing linker protein 2 "GO:0005634,GO:0005737,GO:0005875,GO:0008017,GO:0031122,GO:0035371,GO:0051010" nucleus|cytoplasm|microtubule associated complex|microtubule binding|cytoplasmic microtubule organization|microtubule plus-end|microtubule plus-end binding CLIP3 8.967435311 8.323311061 9.61155956 1.154775965 0.207612985 0.965671908 1 0.124425718 0.141279474 25999 CAP-Gly domain containing linker protein 3 "GO:0001934,GO:0005515,GO:0005634,GO:0005737,GO:0005795,GO:0005802,GO:0005829,GO:0005886,GO:0008017,GO:0010803,GO:0010828,GO:0018230,GO:0031115,GO:0031122,GO:0031901,GO:0032588,GO:0035371,GO:0035594,GO:0043065,GO:0044091,GO:0045121,GO:0045444,GO:0045807,GO:0051010,GO:0055038,GO:0072321,GO:1903078" positive regulation of protein phosphorylation|protein binding|nucleus|cytoplasm|Golgi stack|trans-Golgi network|cytosol|plasma membrane|microtubule binding|regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of glucose transmembrane transport|peptidyl-L-cysteine S-palmitoylation|negative regulation of microtubule polymerization|cytoplasmic microtubule organization|early endosome membrane|trans-Golgi network membrane|microtubule plus-end|ganglioside binding|positive regulation of apoptotic process|membrane biogenesis|membrane raft|fat cell differentiation|positive regulation of endocytosis|microtubule plus-end binding|recycling endosome membrane|chaperone-mediated protein transport|positive regulation of protein localization to plasma membrane CLIP4 1314.114887 1355.659289 1272.570486 0.938709671 -0.091249072 0.706483426 1 10.74224865 9.915113082 79745 CAP-Gly domain containing linker protein family member 4 "GO:0005515,GO:0005634,GO:0005737,GO:0031122,GO:0035371,GO:0043231,GO:0051010" protein binding|nucleus|cytoplasm|cytoplasmic microtubule organization|microtubule plus-end|intracellular membrane-bounded organelle|microtubule plus-end binding CLK1 1843.065852 1666.74304 2019.388664 1.211577679 0.276886904 0.242731363 1 38.54030013 45.91319702 1195 CDC like kinase 1 "GO:0004674,GO:0004712,GO:0004715,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0018105,GO:0018107,GO:0018108,GO:0043484,GO:0046777" protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|regulation of RNA splicing|protein autophosphorylation hsa05134 Legionellosis CLK2 795.356669 794.8762063 795.8371316 1.001208899 0.00174302 1 1 19.69409573 19.38795149 1196 CDC like kinase 2 "GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006468,GO:0010212,GO:0016604,GO:0016607,GO:0018108,GO:0042802,GO:0043484,GO:0045721,GO:0046777" protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|protein phosphorylation|response to ionizing radiation|nuclear body|nuclear speck|peptidyl-tyrosine phosphorylation|identical protein binding|regulation of RNA splicing|negative regulation of gluconeogenesis|protein autophosphorylation CLK3 1424.341466 1221.445898 1627.237033 1.332221948 0.413834455 0.083815118 1 34.14684267 44.72994008 1198 CDC like kinase 3 "GO:0001669,GO:0003723,GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006468,GO:0016020,GO:0016607,GO:0018108,GO:0042802,GO:0043484,GO:0045111,GO:0046777" acrosomal vesicle|RNA binding|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|protein phosphorylation|membrane|nuclear speck|peptidyl-tyrosine phosphorylation|identical protein binding|regulation of RNA splicing|intermediate filament cytoskeleton|protein autophosphorylation CLK4 381.6462685 329.8112008 433.4813362 1.31433176 0.394329483 0.178643631 1 7.029320135 9.08425892 57396 CDC like kinase 4 "GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0018108,GO:0043484,GO:0046777" protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|peptidyl-tyrosine phosphorylation|regulation of RNA splicing|protein autophosphorylation hsa05134 Legionellosis CLMN 1333.68645 1087.232507 1580.140392 1.453360142 0.539392247 0.024911556 0.86041596 4.229433681 6.044030451 79789 calmin "GO:0005640,GO:0005737,GO:0007097,GO:0008285,GO:0016021,GO:0031175,GO:0034993,GO:0051015" nuclear outer membrane|cytoplasm|nuclear migration|negative regulation of cell population proliferation|integral component of membrane|neuron projection development|meiotic nuclear membrane microtubule tethering complex|actin filament binding CLMP 1947.716766 1852.977125 2042.456406 1.102256676 0.140460215 0.553796579 1 19.65222248 21.29931265 79827 CXADR like membrane protein "GO:0005515,GO:0005881,GO:0005886,GO:0005923,GO:0009986,GO:0016021,GO:0048565" protein binding|cytoplasmic microtubule|plasma membrane|bicellular tight junction|cell surface|integral component of membrane|digestive tract development CLN3 471.0476349 494.1965943 447.8986755 0.906316799 -0.141912668 0.612985636 1 6.827430479 6.084270236 1201 "CLN3 lysosomal/endosomal transmembrane protein, battenin" "GO:0000139,GO:0001508,GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005765,GO:0005769,GO:0005770,GO:0005773,GO:0005776,GO:0005783,GO:0005794,GO:0005795,GO:0005802,GO:0005829,GO:0005886,GO:0005901,GO:0006898,GO:0007040,GO:0007042,GO:0007611,GO:0008021,GO:0008306,GO:0009992,GO:0010762,GO:0015809,GO:0016021,GO:0016485,GO:0030176,GO:0031901,GO:0031902,GO:0032228,GO:0035235,GO:0035752,GO:0036359,GO:0042133,GO:0042987,GO:0042998,GO:0043005,GO:0043066,GO:0043086,GO:0043524,GO:0044754,GO:0044857,GO:0045121,GO:0045861,GO:0046474,GO:0046836,GO:0047496,GO:0048172,GO:0048549,GO:0050885,GO:0051453,GO:0051480,GO:0051493,GO:0051861,GO:0051966,GO:0055037,GO:0061024,GO:0061909,GO:0070613,GO:0090160,GO:0090384,GO:0090385,GO:0097352,GO:0106049,GO:0120146,GO:1900079,GO:1901096,GO:1903076,GO:1905146,GO:1905162,GO:1905244,GO:2001288" "Golgi membrane|action potential|protein binding|nucleus|cytoplasm|lysosome|lysosomal membrane|early endosome|late endosome|vacuole|autophagosome|endoplasmic reticulum|Golgi apparatus|Golgi stack|trans-Golgi network|cytosol|plasma membrane|caveola|receptor-mediated endocytosis|lysosome organization|lysosomal lumen acidification|learning or memory|synaptic vesicle|associative learning|cellular water homeostasis|regulation of fibroblast migration|arginine transport|integral component of membrane|protein processing|integral component of endoplasmic reticulum membrane|early endosome membrane|late endosome membrane|regulation of synaptic transmission, GABAergic|ionotropic glutamate receptor signaling pathway|lysosomal lumen pH elevation|renal potassium excretion|neurotransmitter metabolic process|amyloid precursor protein catabolic process|positive regulation of Golgi to plasma membrane protein transport|neuron projection|negative regulation of apoptotic process|negative regulation of catalytic activity|negative regulation of neuron apoptotic process|autolysosome|plasma membrane raft organization|membrane raft|negative regulation of proteolysis|glycerophospholipid biosynthetic process|glycolipid transport|vesicle transport along microtubule|regulation of short-term neuronal synaptic plasticity|positive regulation of pinocytosis|neuromuscular process controlling balance|regulation of intracellular pH|regulation of cytosolic calcium ion concentration|regulation of cytoskeleton organization|glycolipid binding|regulation of synaptic transmission, glutamatergic|recycling endosome|membrane organization|autophagosome-lysosome fusion|regulation of protein processing|Golgi to lysosome transport|phagosome-lysosome docking|phagosome-lysosome fusion|autophagosome maturation|regulation of cellular response to osmotic stress|sulfatide binding|regulation of arginine biosynthetic process|regulation of autophagosome maturation|regulation of protein localization to plasma membrane|lysosomal protein catabolic process|regulation of phagosome maturation|regulation of modification of synaptic structure|positive regulation of caveolin-mediated endocytosis" hsa04142 Lysosome CLN5 441.6581507 479.6307999 403.6855015 0.841658838 -0.248692533 0.379000452 1 4.842416622 4.007462049 1203 CLN5 intracellular trafficking protein "GO:0005515,GO:0005537,GO:0005764,GO:0005765,GO:0005783,GO:0005794,GO:0005829,GO:0006465,GO:0007040,GO:0007042,GO:0007420,GO:0016021,GO:0016798,GO:0022008,GO:0030163,GO:0042147,GO:0042551,GO:0048471,GO:0070062,GO:0070085,GO:1904426" "protein binding|mannose binding|lysosome|lysosomal membrane|endoplasmic reticulum|Golgi apparatus|cytosol|signal peptide processing|lysosome organization|lysosomal lumen acidification|brain development|integral component of membrane|hydrolase activity, acting on glycosyl bonds|neurogenesis|protein catabolic process|retrograde transport, endosome to Golgi|neuron maturation|perinuclear region of cytoplasm|extracellular exosome|glycosylation|positive regulation of GTP binding" hsa04142 Lysosome CLN6 385.9362574 417.2059669 354.6665478 0.850099413 -0.23429653 0.424842593 1 9.993498951 8.353307451 54982 CLN6 transmembrane ER protein "GO:0001573,GO:0005515,GO:0005730,GO:0005769,GO:0005783,GO:0005788,GO:0005789,GO:0007040,GO:0007042,GO:0007601,GO:0008203,GO:0016020,GO:0016021,GO:0030163,GO:0030203,GO:0031987,GO:0035727,GO:0042803,GO:0043231,GO:0044265,GO:0045121,GO:0045862,GO:0120146" ganglioside metabolic process|protein binding|nucleolus|early endosome|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|lysosome organization|lysosomal lumen acidification|visual perception|cholesterol metabolic process|membrane|integral component of membrane|protein catabolic process|glycosaminoglycan metabolic process|locomotion involved in locomotory behavior|lysophosphatidic acid binding|protein homodimerization activity|intracellular membrane-bounded organelle|cellular macromolecule catabolic process|membrane raft|positive regulation of proteolysis|sulfatide binding CLN8 158.0793579 175.8299462 140.3287696 0.798093684 -0.325369987 0.417467409 1 2.638099822 2.070218939 2055 CLN8 transmembrane ER and ERGIC protein "GO:0001306,GO:0005515,GO:0005739,GO:0005783,GO:0005789,GO:0005793,GO:0006644,GO:0006672,GO:0006869,GO:0007006,GO:0007040,GO:0007399,GO:0007601,GO:0007628,GO:0008203,GO:0008306,GO:0008361,GO:0008610,GO:0016021,GO:0021523,GO:0030163,GO:0033116,GO:0035176,GO:0043066,GO:0044257,GO:0045494,GO:0045861,GO:0046513,GO:0050881,GO:0050884,GO:0050885,GO:0051935,GO:0055088,GO:0060041,GO:0060052,GO:0097001,GO:0098793" age-dependent response to oxidative stress|protein binding|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|phospholipid metabolic process|ceramide metabolic process|lipid transport|mitochondrial membrane organization|lysosome organization|nervous system development|visual perception|adult walking behavior|cholesterol metabolic process|associative learning|regulation of cell size|lipid biosynthetic process|integral component of membrane|somatic motor neuron differentiation|protein catabolic process|endoplasmic reticulum-Golgi intermediate compartment membrane|social behavior|negative regulation of apoptotic process|cellular protein catabolic process|photoreceptor cell maintenance|negative regulation of proteolysis|ceramide biosynthetic process|musculoskeletal movement|neuromuscular process controlling posture|neuromuscular process controlling balance|glutamate reuptake|lipid homeostasis|retina development in camera-type eye|neurofilament cytoskeleton organization|ceramide binding|presynapse CLNS1A 2917.939038 2709.23775 3126.640325 1.154066425 0.206726264 0.382565157 1 46.19394229 52.41879249 1207 chloride nucleotide-sensitive channel 1A "GO:0000387,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005856,GO:0005886,GO:0006821,GO:0006884,GO:0034709,GO:0034715" spliceosomal snRNP assembly|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|cytoskeleton|plasma membrane|chloride transport|cell volume homeostasis|methylosome|pICln-Sm protein complex hsa03013 RNA transport CLOCK 740.3625738 814.6440701 666.0810775 0.817634476 -0.290472065 0.253341313 1 3.678799862 2.957580237 9575 clock circadian regulator "GO:0000077,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005694,GO:0005829,GO:0006355,GO:0006357,GO:0006473,GO:0007165,GO:0007283,GO:0007623,GO:0009648,GO:0016573,GO:0031490,GO:0032922,GO:0033391,GO:0042634,GO:0042752,GO:0043161,GO:0043231,GO:0043565,GO:0045892,GO:0045893,GO:0045944,GO:0046983,GO:0050729,GO:0050796,GO:0051092,GO:0051775,GO:0070888,GO:0071479,GO:1990513,GO:1990837,GO:2000074,GO:2000323" "DNA damage checkpoint|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|chromosome|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|protein acetylation|signal transduction|spermatogenesis|circadian rhythm|photoperiodism|histone acetylation|chromatin DNA binding|circadian regulation of gene expression|chromatoid body|regulation of hair cycle|regulation of circadian rhythm|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|positive regulation of inflammatory response|regulation of insulin secretion|positive regulation of NF-kappaB transcription factor activity|response to redox state|E-box binding|cellular response to ionizing radiation|CLOCK-BMAL transcription complex|sequence-specific double-stranded DNA binding|regulation of type B pancreatic cell development|negative regulation of glucocorticoid receptor signaling pathway" "hsa04710,hsa04728" Circadian rhythm|Dopaminergic synapse bHLH CLP1 260.1694805 256.982229 263.3567319 1.024805229 0.035349741 0.927128411 1 8.383049663 8.447234491 10978 cleavage factor polyribonucleotide kinase subunit 1 "GO:0000214,GO:0000398,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005849,GO:0006369,GO:0006378,GO:0006388,GO:0006396,GO:0016310,GO:0021695,GO:0030423,GO:0031124,GO:0035087,GO:0046404,GO:0051731,GO:0051733,GO:0051736" "tRNA-intron endonuclease complex|mRNA splicing, via spliceosome|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|mRNA cleavage factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|tRNA splicing, via endonucleolytic cleavage and ligation|RNA processing|phosphorylation|cerebellar cortex development|targeting of mRNA for destruction involved in RNA interference|mRNA 3'-end processing|siRNA loading onto RISC involved in RNA interference|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|polynucleotide 5'-hydroxyl-kinase activity|polydeoxyribonucleotide kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity" hsa03015 mRNA surveillance pathway CLPB 708.7444212 665.8648849 751.6239576 1.128793505 0.174781593 0.496459193 1 3.454791474 3.834489207 81570 caseinolytic mitochondrial matrix peptidase chaperone subunit B "GO:0003674,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005758,GO:0016887,GO:0034605,GO:0039529,GO:0140374" molecular_function|protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial intermembrane space|ATPase activity|cellular response to heat|RIG-I signaling pathway|antiviral innate immune response hsa04213 Longevity regulating pathway - multiple species CLPP 766.3294903 676.2690237 856.3899568 1.266345089 0.340670604 0.178268406 1 14.97561613 18.64695609 8192 caseinolytic mitochondrial matrix peptidase proteolytic subunit "GO:0004175,GO:0004176,GO:0004252,GO:0005515,GO:0005739,GO:0005759,GO:0006515,GO:0008233,GO:0009368,GO:0033619,GO:0042802,GO:0051117,GO:0051603" endopeptidase activity|ATP-dependent peptidase activity|serine-type endopeptidase activity|protein binding|mitochondrion|mitochondrial matrix|protein quality control for misfolded or incompletely synthesized proteins|peptidase activity|endopeptidase Clp complex|membrane protein proteolysis|identical protein binding|ATPase binding|proteolysis involved in cellular protein catabolic process CLPTM1 1245.160108 1236.011693 1254.308523 1.01480312 0.021199861 0.933544568 1 24.61331057 24.55969699 1209 CLPTM1 regulator of GABA type A receptor forward trafficking "GO:0005515,GO:0005887,GO:0007275,GO:0009897,GO:0012505,GO:0016020,GO:0030154,GO:0033081" protein binding|integral component of plasma membrane|multicellular organism development|external side of plasma membrane|endomembrane system|membrane|cell differentiation|regulation of T cell differentiation in thymus CLPTM1L 2476.345054 2269.142678 2683.547429 1.182626132 0.241994062 0.306094118 1 52.40154661 60.9344303 81037 CLPTM1 like "GO:0005515,GO:0006915,GO:0012505,GO:0016020,GO:0016021" protein binding|apoptotic process|endomembrane system|membrane|integral component of membrane CLPX 556.9666829 554.5405994 559.3927664 1.008749886 0.01256851 0.969946068 1 6.260802325 6.209900892 10845 caseinolytic mitochondrial matrix peptidase chaperone subunit X "GO:0004176,GO:0005515,GO:0005524,GO:0005654,GO:0005739,GO:0005743,GO:0005759,GO:0005829,GO:0006457,GO:0006508,GO:0008270,GO:0009368,GO:0009841,GO:0010952,GO:0016504,GO:0016887,GO:0030163,GO:0042645,GO:0046034,GO:0046983,GO:0051082,GO:0051603" ATP-dependent peptidase activity|protein binding|ATP binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|cytosol|protein folding|proteolysis|zinc ion binding|endopeptidase Clp complex|mitochondrial endopeptidase Clp complex|positive regulation of peptidase activity|peptidase activator activity|ATPase activity|protein catabolic process|mitochondrial nucleoid|ATP metabolic process|protein dimerization activity|unfolded protein binding|proteolysis involved in cellular protein catabolic process CLSPN 642.7366616 686.6731625 598.8001606 0.872030819 -0.197548971 0.448657567 1 3.94599813 3.383450972 63967 claspin "GO:0000076,GO:0000077,GO:0000217,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0006260,GO:0006281,GO:0007095,GO:0010997,GO:0016579,GO:0018105,GO:0032147,GO:0033314" DNA replication checkpoint|DNA damage checkpoint|DNA secondary structure binding|protein binding|nucleus|nucleoplasm|Golgi apparatus|DNA replication|DNA repair|mitotic G2 DNA damage checkpoint|anaphase-promoting complex binding|protein deubiquitination|peptidyl-serine phosphorylation|activation of protein kinase activity|mitotic DNA replication checkpoint CLSTN1 7315.90315 7294.341731 7337.464568 1.00591182 0.008503842 0.972939882 1 73.16023525 72.36127048 22883 calsyntenin 1 "GO:0000139,GO:0001540,GO:0001558,GO:0005509,GO:0005515,GO:0005576,GO:0005634,GO:0005789,GO:0007155,GO:0007156,GO:0009986,GO:0019894,GO:0042988,GO:0045211,GO:0050806,GO:0051965,GO:0090128,GO:0098845,GO:0098969,GO:0098978,GO:0098982,GO:0099003,GO:0099061,GO:0099065" Golgi membrane|amyloid-beta binding|regulation of cell growth|calcium ion binding|protein binding|extracellular region|nucleus|endoplasmic reticulum membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell surface|kinesin binding|X11-like protein binding|postsynaptic membrane|positive regulation of synaptic transmission|positive regulation of synapse assembly|regulation of synapse maturation|postsynaptic endosome|neurotransmitter receptor transport to postsynaptic membrane|glutamatergic synapse|GABA-ergic synapse|vesicle-mediated transport in synapse|integral component of postsynaptic density membrane|integral component of spine apparatus membrane CLSTN3 1496.77795 1546.05503 1447.50087 0.93625443 -0.095027456 0.692301099 1 14.52131563 13.36814135 9746 calsyntenin 3 "GO:0000139,GO:0001558,GO:0005509,GO:0005515,GO:0005789,GO:0007156,GO:0007416,GO:0009986,GO:0030425,GO:0032991,GO:0035249,GO:0045211,GO:0050806,GO:0051932,GO:0051965,GO:0098978,GO:0098982,GO:0099061,GO:1902474,GO:1905606" "Golgi membrane|regulation of cell growth|calcium ion binding|protein binding|endoplasmic reticulum membrane|homophilic cell adhesion via plasma membrane adhesion molecules|synapse assembly|cell surface|dendrite|protein-containing complex|synaptic transmission, glutamatergic|postsynaptic membrane|positive regulation of synaptic transmission|synaptic transmission, GABAergic|positive regulation of synapse assembly|glutamatergic synapse|GABA-ergic synapse|integral component of postsynaptic density membrane|positive regulation of protein localization to synapse|regulation of presynapse assembly" CLTA 4154.299672 4017.038001 4291.561344 1.068339743 0.095370511 0.68969046 1 225.1911083 236.55482 1211 clathrin light chain A "GO:0003674,GO:0005198,GO:0005515,GO:0005819,GO:0005829,GO:0005886,GO:0006886,GO:0007049,GO:0016020,GO:0019886,GO:0030118,GO:0030125,GO:0030130,GO:0030132,GO:0030672,GO:0031410,GO:0032050,GO:0032588,GO:0032802,GO:0034383,GO:0036020,GO:0042277,GO:0044877,GO:0045334,GO:0048268,GO:0051020,GO:0051301,GO:0061024,GO:0071439,GO:0072583,GO:0098835,GO:0099631" molecular_function|structural molecule activity|protein binding|spindle|cytosol|plasma membrane|intracellular protein transport|cell cycle|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|clathrin coat|clathrin vesicle coat|clathrin coat of trans-Golgi network vesicle|clathrin coat of coated pit|synaptic vesicle membrane|cytoplasmic vesicle|clathrin heavy chain binding|trans-Golgi network membrane|low-density lipoprotein particle receptor catabolic process|low-density lipoprotein particle clearance|endolysosome membrane|peptide binding|protein-containing complex binding|clathrin-coated endocytic vesicle|clathrin coat assembly|GTPase binding|cell division|membrane organization|clathrin complex|clathrin-dependent endocytosis|presynaptic endocytic zone membrane|postsynaptic endocytic zone cytoplasmic component "hsa04142,hsa04144,hsa04721,hsa04961,hsa05016,hsa05100" Lysosome|Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease|Bacterial invasion of epithelial cells CLTB 1122.178033 1022.726847 1221.62922 1.194482402 0.256385599 0.292594505 1 21.81496887 25.62155782 1212 clathrin light chain B "GO:0005198,GO:0005515,GO:0005802,GO:0005829,GO:0005886,GO:0006886,GO:0030118,GO:0030125,GO:0030130,GO:0030132,GO:0030672,GO:0032050,GO:0042277,GO:0043231,GO:0045334,GO:0048268,GO:0060170,GO:0061024,GO:0072583,GO:0098835,GO:0099631" structural molecule activity|protein binding|trans-Golgi network|cytosol|plasma membrane|intracellular protein transport|clathrin coat|clathrin vesicle coat|clathrin coat of trans-Golgi network vesicle|clathrin coat of coated pit|synaptic vesicle membrane|clathrin heavy chain binding|peptide binding|intracellular membrane-bounded organelle|clathrin-coated endocytic vesicle|clathrin coat assembly|ciliary membrane|membrane organization|clathrin-dependent endocytosis|presynaptic endocytic zone membrane|postsynaptic endocytic zone cytoplasmic component "hsa04142,hsa04144,hsa04721,hsa04961,hsa05016,hsa05100" Lysosome|Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease|Bacterial invasion of epithelial cells CLTC 18432.0011 18305.04185 18558.96035 1.013871506 0.019874823 0.941503492 1 116.729172 116.3679815 1213 clathrin heavy chain "GO:0000278,GO:0001649,GO:0003723,GO:0003725,GO:0005198,GO:0005515,GO:0005764,GO:0005768,GO:0005819,GO:0005829,GO:0005886,GO:0005925,GO:0006886,GO:0006898,GO:0006914,GO:0016020,GO:0019886,GO:0019901,GO:0030118,GO:0030130,GO:0030132,GO:0030136,GO:0030669,GO:0031623,GO:0032051,GO:0032588,GO:0032802,GO:0032991,GO:0033572,GO:0034383,GO:0036020,GO:0042147,GO:0042470,GO:0045334,GO:0048268,GO:0050750,GO:0051301,GO:0060071,GO:0060236,GO:0061024,GO:0070062,GO:0071439,GO:0072583,GO:0072686,GO:0097718,GO:0150093,GO:1900126,GO:1903077,GO:1903561,GO:1990381,GO:1990498" "mitotic cell cycle|osteoblast differentiation|RNA binding|double-stranded RNA binding|structural molecule activity|protein binding|lysosome|endosome|spindle|cytosol|plasma membrane|focal adhesion|intracellular protein transport|receptor-mediated endocytosis|autophagy|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|clathrin coat|clathrin coat of trans-Golgi network vesicle|clathrin coat of coated pit|clathrin-coated vesicle|clathrin-coated endocytic vesicle membrane|receptor internalization|clathrin light chain binding|trans-Golgi network membrane|low-density lipoprotein particle receptor catabolic process|protein-containing complex|transferrin transport|low-density lipoprotein particle clearance|endolysosome membrane|retrograde transport, endosome to Golgi|melanosome|clathrin-coated endocytic vesicle|clathrin coat assembly|low-density lipoprotein particle receptor binding|cell division|Wnt signaling pathway, planar cell polarity pathway|regulation of mitotic spindle organization|membrane organization|extracellular exosome|clathrin complex|clathrin-dependent endocytosis|mitotic spindle|disordered domain specific binding|amyloid-beta clearance by transcytosis|negative regulation of hyaluronan biosynthetic process|negative regulation of protein localization to plasma membrane|extracellular vesicle|ubiquitin-specific protease binding|mitotic spindle microtubule" "hsa04142,hsa04144,hsa04721,hsa04961,hsa05016,hsa05100" Lysosome|Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease|Bacterial invasion of epithelial cells CLTCL1 406.1450701 455.7012806 356.5888597 0.782505722 -0.353826793 0.219469718 1 4.336651177 3.336669498 8218 clathrin heavy chain like 1 "GO:0000278,GO:0005198,GO:0005515,GO:0005769,GO:0005770,GO:0005802,GO:0005819,GO:0005829,GO:0005886,GO:0005905,GO:0006886,GO:0006898,GO:0009653,GO:0016020,GO:0030130,GO:0030135,GO:0030136,GO:0032051,GO:0042147,GO:0045334,GO:0046326,GO:0055037,GO:0061024,GO:0070062,GO:0071439,GO:0097443" "mitotic cell cycle|structural molecule activity|protein binding|early endosome|late endosome|trans-Golgi network|spindle|cytosol|plasma membrane|clathrin-coated pit|intracellular protein transport|receptor-mediated endocytosis|anatomical structure morphogenesis|membrane|clathrin coat of trans-Golgi network vesicle|coated vesicle|clathrin-coated vesicle|clathrin light chain binding|retrograde transport, endosome to Golgi|clathrin-coated endocytic vesicle|positive regulation of glucose import|recycling endosome|membrane organization|extracellular exosome|clathrin complex|sorting endosome" "hsa04142,hsa04144,hsa04721,hsa04961,hsa05016,hsa05100" Lysosome|Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease|Bacterial invasion of epithelial cells CLTRN 11.40995416 9.363724944 13.45618338 1.437054534 0.523114811 0.682534404 1 0.306579626 0.433199272 57393 "collectrin, amino acid transport regulator" "GO:0005515,GO:0005737,GO:0005886,GO:0016021,GO:0022898,GO:0035543,GO:0035774,GO:0042803,GO:0045956,GO:0051957,GO:0070062,GO:1905737" protein binding|cytoplasm|plasma membrane|integral component of membrane|regulation of transmembrane transporter activity|positive regulation of SNARE complex assembly|positive regulation of insulin secretion involved in cellular response to glucose stimulus|protein homodimerization activity|positive regulation of calcium ion-dependent exocytosis|positive regulation of amino acid transport|extracellular exosome|positive regulation of L-proline import across plasma membrane CLU 215.5757225 108.2030438 322.9484012 2.984651724 1.577562595 1.33E-05 0.006288701 2.100617526 6.164698259 1191 clusterin "GO:0000902,GO:0001540,GO:0001774,GO:0001836,GO:0002434,GO:0002576,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005739,GO:0005743,GO:0005794,GO:0005829,GO:0005856,GO:0006629,GO:0006956,GO:0006958,GO:0009615,GO:0009986,GO:0010628,GO:0016020,GO:0016887,GO:0017038,GO:0019730,GO:0030449,GO:0031093,GO:0031333,GO:0031334,GO:0031625,GO:0032286,GO:0032436,GO:0032760,GO:0032991,GO:0034366,GO:0042127,GO:0042583,GO:0042981,GO:0043065,GO:0043231,GO:0043691,GO:0044877,GO:0045087,GO:0045202,GO:0045429,GO:0048156,GO:0048260,GO:0048471,GO:0050750,GO:0050821,GO:0051082,GO:0051087,GO:0051092,GO:0051131,GO:0051787,GO:0051788,GO:0060548,GO:0061077,GO:0061518,GO:0061740,GO:0061741,GO:0062023,GO:0070062,GO:0071944,GO:0072562,GO:0090201,GO:0097418,GO:0097440,GO:0099020,GO:1900221,GO:1901214,GO:1901216,GO:1902004,GO:1902230,GO:1902430,GO:1902847,GO:1902949,GO:1902998,GO:1903573,GO:1905892,GO:1905895,GO:1905907,GO:1905908,GO:2000060" "cell morphogenesis|amyloid-beta binding|microglial cell activation|release of cytochrome c from mitochondria|immune complex clearance|platelet degranulation|signaling receptor binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|mitochondrion|mitochondrial inner membrane|Golgi apparatus|cytosol|cytoskeleton|lipid metabolic process|complement activation|complement activation, classical pathway|response to virus|cell surface|positive regulation of gene expression|membrane|ATPase activity|protein import|antimicrobial humoral response|regulation of complement activation|platelet alpha granule lumen|negative regulation of protein-containing complex assembly|positive regulation of protein-containing complex assembly|ubiquitin protein ligase binding|central nervous system myelin maintenance|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of tumor necrosis factor production|protein-containing complex|spherical high-density lipoprotein particle|regulation of cell population proliferation|chromaffin granule|regulation of apoptotic process|positive regulation of apoptotic process|intracellular membrane-bounded organelle|reverse cholesterol transport|protein-containing complex binding|innate immune response|synapse|positive regulation of nitric oxide biosynthetic process|tau protein binding|positive regulation of receptor-mediated endocytosis|perinuclear region of cytoplasm|low-density lipoprotein particle receptor binding|protein stabilization|unfolded protein binding|chaperone binding|positive regulation of NF-kappaB transcription factor activity|chaperone-mediated protein complex assembly|misfolded protein binding|response to misfolded protein|negative regulation of cell death|chaperone-mediated protein folding|microglial cell proliferation|protein targeting to lysosome involved in chaperone-mediated autophagy|chaperone-mediated protein transport involved in chaperone-mediated autophagy|collagen-containing extracellular matrix|extracellular exosome|cell periphery|blood microparticle|negative regulation of release of cytochrome c from mitochondria|neurofibrillary tangle|apical dendrite|perinuclear endoplasmic reticulum lumen|regulation of amyloid-beta clearance|regulation of neuron death|positive regulation of neuron death|positive regulation of amyloid-beta formation|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of amyloid-beta formation|regulation of neuronal signal transduction|positive regulation of tau-protein kinase activity|positive regulation of neurofibrillary tangle assembly|negative regulation of response to endoplasmic reticulum stress|negative regulation of cellular response to thapsigargin|negative regulation of cellular response to tunicamycin|negative regulation of amyloid fibril formation|positive regulation of amyloid fibril formation|positive regulation of ubiquitin-dependent protein catabolic process" hsa04610 Complement and coagulation cascades CLUAP1 400.3139677 416.1655531 384.4623824 0.923820772 -0.11431511 0.698620502 1 5.240677368 4.760431558 23059 clusterin associated protein 1 "GO:0005515,GO:0005654,GO:0005813,GO:0005929,GO:0030992,GO:0035735,GO:0043231,GO:0060271,GO:0097542" protein binding|nucleoplasm|centrosome|cilium|intraciliary transport particle B|intraciliary transport involved in cilium assembly|intracellular membrane-bounded organelle|cilium assembly|ciliary tip CLUH 1516.549615 1774.946084 1258.153146 0.708840205 -0.496467659 0.037482369 0.976326461 14.24016992 9.925095463 23277 clustered mitochondria homolog "GO:0003729,GO:0005737,GO:0007005,GO:0048312" mRNA binding|cytoplasm|mitochondrion organization|intracellular distribution of mitochondria CLYBL 120.9364594 121.7284243 120.1444945 0.986988004 -0.018895545 0.986965614 1 0.831063359 0.8065238 171425 citramalyl-CoA lyase "GO:0000287,GO:0004474,GO:0005739,GO:0016787,GO:0047777,GO:0070207,GO:0106064,GO:0106121" magnesium ion binding|malate synthase activity|mitochondrion|hydrolase activity|(S)-citramalyl-CoA lyase activity|protein homotrimerization|regulation of cobalamin metabolic process|positive regulation of cobalamin metabolic process CMAS 1992.491004 1653.21766 2331.764349 1.41044002 0.496145316 0.036208037 0.964754921 50.47436385 69.99977674 55907 cytidine monophosphate N-acetylneuraminic acid synthetase "GO:0005634,GO:0005654,GO:0006054,GO:0008781,GO:0016020" nucleus|nucleoplasm|N-acetylneuraminate metabolic process|N-acylneuraminate cytidylyltransferase activity|membrane hsa00520 Amino sugar and nucleotide sugar metabolism CMBL 858.8615448 922.8471139 794.8759756 0.861330077 -0.215361885 0.389091312 1 12.65107998 10.71441324 134147 carboxymethylenebutenolidase homolog "GO:0005829,GO:0006805,GO:0016787,GO:0070062" cytosol|xenobiotic metabolic process|hydrolase activity|extracellular exosome CMC1 449.2983229 402.6401726 495.9564733 1.231761029 0.300722389 0.284634954 1 2.047466983 2.47978795 152100 C-X9-C motif containing 1 "GO:0005739,GO:0046872" mitochondrion|metal ion binding CMC2 857.0341964 786.5528953 927.5154975 1.179215668 0.237827598 0.341512885 1 4.051040571 4.697113041 56942 C-X9-C motif containing 2 "GO:0005515,GO:0005739" protein binding|mitochondrion CMC4 137.2710802 134.2133909 140.3287696 1.045564594 0.064282194 0.895645833 1 8.13021793 8.358420845 100272147 C-X9-C motif containing 4 "GO:0005739,GO:0005758" mitochondrion|mitochondrial intermembrane space CMIP 1828.505088 1625.126485 2031.883691 1.250292645 0.322265813 0.17398409 1 7.371866862 9.062757057 80790 c-Maf inducing protein "GO:0001701,GO:0005515,GO:0005654,GO:0005829" in utero embryonic development|protein binding|nucleoplasm|cytosol CMPK1 2950.088072 2733.16727 3167.008875 1.158732182 0.212547155 0.36934958 1 49.66432204 56.5846663 51727 cytidine/uridine monophosphate kinase 1 "GO:0004127,GO:0004550,GO:0004849,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006163,GO:0006165,GO:0006207,GO:0006222,GO:0006225,GO:0009142,GO:0009220,GO:0015949,GO:0033862,GO:0046705,GO:0046940,GO:0070062" cytidylate kinase activity|nucleoside diphosphate kinase activity|uridine kinase activity|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|purine nucleotide metabolic process|nucleoside diphosphate phosphorylation|'de novo' pyrimidine nucleobase biosynthetic process|UMP biosynthetic process|UDP biosynthetic process|nucleoside triphosphate biosynthetic process|pyrimidine ribonucleotide biosynthetic process|nucleobase-containing small molecule interconversion|UMP kinase activity|CDP biosynthetic process|nucleoside monophosphate phosphorylation|extracellular exosome "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes CMSS1 627.2248025 620.0866741 634.362931 1.023023002 0.032838584 0.906078945 1 7.576210193 7.620940879 84319 cms1 ribosomal small subunit homolog "GO:0003723,GO:0005515" RNA binding|protein binding CMTM1 16.05218767 17.687036 14.41733934 0.815135975 -0.294887356 0.808237641 1 1.312829769 1.052227518 113540 CKLF like MARVEL transmembrane domain containing 1 "GO:0005125,GO:0005615,GO:0006935,GO:0007165,GO:0016021" cytokine activity|extracellular space|chemotaxis|signal transduction|integral component of membrane CMTM3 1355.226941 1299.476939 1410.976943 1.085803757 0.118763381 0.622365491 1 29.52349762 31.52029878 123920 CKLF like MARVEL transmembrane domain containing 3 "GO:0005125,GO:0005515,GO:0005615,GO:0005829,GO:0006935,GO:0007165,GO:0016021,GO:0031410" cytokine activity|protein binding|extracellular space|cytosol|chemotaxis|signal transduction|integral component of membrane|cytoplasmic vesicle CMTM4 1290.571597 1343.174322 1237.968871 0.921674015 -0.117671517 0.626782683 1 8.130982865 7.368711752 146223 CKLF like MARVEL transmembrane domain containing 4 "GO:0005515,GO:0016021" protein binding|integral component of membrane CMTM6 2991.442931 2670.742437 3312.143424 1.240158309 0.310524296 0.18969328 1 43.10027676 52.55673346 54918 CKLF like MARVEL transmembrane domain containing 6 "GO:0005515,GO:0005886,GO:0015031,GO:0016020,GO:0016021,GO:0031647,GO:0031901,GO:0032456,GO:0035577,GO:0035579,GO:0043231,GO:0043312,GO:0055038" protein binding|plasma membrane|protein transport|membrane|integral component of membrane|regulation of protein stability|early endosome membrane|endocytic recycling|azurophil granule membrane|specific granule membrane|intracellular membrane-bounded organelle|neutrophil degranulation|recycling endosome membrane CMTM7 556.3376499 525.4090107 587.2662891 1.117731666 0.160573882 0.550707192 1 12.72237443 13.98224497 112616 CKLF like MARVEL transmembrane domain containing 7 "GO:0002337,GO:0005125,GO:0005515,GO:0005615,GO:0006935,GO:0007165,GO:0016020,GO:0016021" B-1a B cell differentiation|cytokine activity|protein binding|extracellular space|chemotaxis|signal transduction|membrane|integral component of membrane CMTM8 30.90544561 29.13158871 32.6793025 1.121782366 0.165792809 0.860178741 1 0.735430155 0.811187446 152189 CKLF like MARVEL transmembrane domain containing 8 "GO:0005125,GO:0005515,GO:0005615,GO:0005654,GO:0005737,GO:0006935,GO:0007165,GO:0016021,GO:0019911,GO:0042552" cytokine activity|protein binding|extracellular space|nucleoplasm|cytoplasm|chemotaxis|signal transduction|integral component of membrane|structural constituent of myelin sheath|myelination CMTR1 1000.918897 1006.080225 995.7575704 0.989739731 -0.014878902 0.956156191 1 12.23903635 11.91075819 23070 cap methyltransferase 1 "GO:0003676,GO:0004483,GO:0005634,GO:0005654,GO:0005737,GO:0006370,GO:0043231,GO:0080009,GO:0097309" nucleic acid binding|mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleus|nucleoplasm|cytoplasm|7-methylguanosine mRNA capping|intracellular membrane-bounded organelle|mRNA methylation|cap1 mRNA methylation CMTR2 656.8916894 641.9353656 671.8480132 1.0465976 0.065706856 0.804693379 1 5.941538438 6.114343372 55783 cap methyltransferase 2 "GO:0004483,GO:0005634,GO:0005737,GO:0006370,GO:0097309,GO:0097310" mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleus|cytoplasm|7-methylguanosine mRNA capping|cap1 mRNA methylation|cap2 mRNA methylation CMYA5 9.487642252 9.363724944 9.61155956 1.026467524 0.037687984 1 1 0.038508499 0.038866281 202333 cardiomyopathy associated 5 "GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0016529,GO:0016607,GO:0031430,GO:0043231,GO:0048471" protein binding|nucleus|cytosol|plasma membrane|sarcoplasmic reticulum|nuclear speck|M band|intracellular membrane-bounded organelle|perinuclear region of cytoplasm CNBD2 8.447228369 7.282897178 9.61155956 1.31974396 0.400258063 0.833324456 1 0.134303676 0.174280485 140894 cyclic nucleotide binding domain containing 2 "GO:0005829,GO:0007283,GO:0030552" cytosol|spermatogenesis|cAMP binding CNBP 5175.198441 5232.241416 5118.155466 0.978195587 -0.031805138 0.895492585 1 84.59106571 81.36195481 7555 CCHC-type zinc finger nucleic acid binding protein "GO:0000122,GO:0003697,GO:0003723,GO:0003727,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0006355,GO:0008270,GO:0008284,GO:0042632,GO:0045182,GO:0045893,GO:0045944,GO:0051880,GO:0071919,GO:2000767" "negative regulation of transcription by RNA polymerase II|single-stranded DNA binding|RNA binding|single-stranded RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|endoplasmic reticulum|cytosol|regulation of transcription, DNA-templated|zinc ion binding|positive regulation of cell population proliferation|cholesterol homeostasis|translation regulator activity|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|G-quadruplex DNA binding|G-quadruplex DNA formation|positive regulation of cytoplasmic translation" CNDP2 3185.965114 3147.251995 3224.678232 1.02460122 0.035062514 0.88360643 1 30.90965303 31.14011249 55748 carnosine dipeptidase 2 "GO:0004180,GO:0005654,GO:0005829,GO:0006508,GO:0006750,GO:0008233,GO:0016805,GO:0046872,GO:0070062,GO:0070573,GO:0102008,GO:0103046" carboxypeptidase activity|nucleoplasm|cytosol|proteolysis|glutathione biosynthetic process|peptidase activity|dipeptidase activity|metal ion binding|extracellular exosome|metallodipeptidase activity|cytosolic dipeptidase activity|alanylglutamate dipeptidase activity "hsa00330,hsa00340,hsa00410" Arginine and proline metabolism|Histidine metabolism|beta-Alanine metabolism CNEP1R1 310.0753627 242.4164347 377.7342907 1.558204134 0.639884248 0.0400306 1 6.037013334 9.249487419 255919 CTD nuclear envelope phosphatase 1 regulatory subunit 1 "GO:0005515,GO:0005635,GO:0005737,GO:0005829,GO:0006629,GO:0007077,GO:0010867,GO:0016021,GO:0031965,GO:0034504,GO:0035307,GO:0071595" protein binding|nuclear envelope|cytoplasm|cytosol|lipid metabolic process|mitotic nuclear envelope disassembly|positive regulation of triglyceride biosynthetic process|integral component of membrane|nuclear membrane|protein localization to nucleus|positive regulation of protein dephosphorylation|Nem1-Spo7 phosphatase complex CNFN 10.60731406 13.52538047 7.689247648 0.56850509 -0.814754828 0.49718369 1 1.142127686 0.638440156 84518 cornifelin "GO:0001533,GO:0005515,GO:0005737,GO:0031424" cornified envelope|protein binding|cytoplasm|keratinization CNGA1 46.07070483 61.38441908 30.75699059 0.501055334 -0.996958159 0.106898005 1 0.782789397 0.385657519 1259 cyclic nucleotide gated channel subunit alpha 1 "GO:0005222,GO:0005223,GO:0005515,GO:0005886,GO:0005887,GO:0007601,GO:0016056,GO:0022400,GO:0030553,GO:0042622,GO:0098655" intracellular cAMP-activated cation channel activity|intracellular cGMP-activated cation channel activity|protein binding|plasma membrane|integral component of plasma membrane|visual perception|rhodopsin mediated signaling pathway|regulation of rhodopsin mediated signaling pathway|cGMP binding|photoreceptor outer segment membrane|cation transmembrane transport "hsa04022,hsa04024,hsa04744" cGMP-PKG signaling pathway|cAMP signaling pathway|Phototransduction CNGB1 12.00941903 12.48496659 11.53387147 0.923820772 -0.11431511 1 1 0.097898872 0.088927603 1258 cyclic nucleotide gated channel subunit beta 1 "GO:0000139,GO:0001750,GO:0001895,GO:0005222,GO:0005223,GO:0005515,GO:0005886,GO:0006812,GO:0007601,GO:0007608,GO:0015276,GO:0016056,GO:0017071,GO:0022400,GO:0030552,GO:0030553,GO:0030660,GO:0033365,GO:0035845,GO:0043195,GO:0044877,GO:0045494,GO:0050908,GO:0051480,GO:0060170,GO:0098655,GO:1902495" Golgi membrane|photoreceptor outer segment|retina homeostasis|intracellular cAMP-activated cation channel activity|intracellular cGMP-activated cation channel activity|protein binding|plasma membrane|cation transport|visual perception|sensory perception of smell|ligand-gated ion channel activity|rhodopsin mediated signaling pathway|intracellular cyclic nucleotide activated cation channel complex|regulation of rhodopsin mediated signaling pathway|cAMP binding|cGMP binding|Golgi-associated vesicle membrane|protein localization to organelle|photoreceptor cell outer segment organization|terminal bouton|protein-containing complex binding|photoreceptor cell maintenance|detection of light stimulus involved in visual perception|regulation of cytosolic calcium ion concentration|ciliary membrane|cation transmembrane transport|transmembrane transporter complex "hsa04022,hsa04024,hsa04740,hsa04744" cGMP-PKG signaling pathway|cAMP signaling pathway|Olfactory transduction|Phototransduction CNIH1 2230.635114 2404.396483 2056.873746 0.855463631 -0.225221573 0.3408769 1 27.09994112 22.79507769 10175 cornichon family AMPA receptor auxiliary protein 1 "GO:0000139,GO:0005515,GO:0005789,GO:0006888,GO:0006955,GO:0007165,GO:0012507,GO:0016021,GO:0033116,GO:0048208" Golgi membrane|protein binding|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|immune response|signal transduction|ER to Golgi transport vesicle membrane|integral component of membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|COPII vesicle coating CNIH2 26.98156386 27.05076095 26.91236677 0.994883908 -0.007399906 1 1 1.050690971 1.0278236 254263 cornichon family AMPA receptor auxiliary protein 2 "GO:0000139,GO:0005515,GO:0005789,GO:0006888,GO:0012507,GO:0014069,GO:0030425,GO:0032281,GO:0033116,GO:0035249,GO:0042391,GO:0043197,GO:0043198,GO:0045202,GO:0045211,GO:0048208,GO:0051668,GO:0098962,GO:0098978,GO:0099061,GO:1902684,GO:1903743,GO:2000310,GO:2000311" "Golgi membrane|protein binding|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|ER to Golgi transport vesicle membrane|postsynaptic density|dendrite|AMPA glutamate receptor complex|endoplasmic reticulum-Golgi intermediate compartment membrane|synaptic transmission, glutamatergic|regulation of membrane potential|dendritic spine|dendritic shaft|synapse|postsynaptic membrane|COPII vesicle coating|localization within membrane|regulation of postsynaptic neurotransmitter receptor activity|glutamatergic synapse|integral component of postsynaptic density membrane|negative regulation of receptor localization to synapse|negative regulation of anterograde synaptic vesicle transport|regulation of NMDA receptor activity|regulation of AMPA receptor activity" CNIH3 775.7668283 810.4824146 741.0512421 0.914333524 -0.129207578 0.611755308 1 14.00711038 12.59285994 149111 cornichon family AMPA receptor auxiliary protein 3 "GO:0000139,GO:0005515,GO:0005789,GO:0006888,GO:0012507,GO:0016247,GO:0030425,GO:0032281,GO:0033116,GO:0035249,GO:0042391,GO:0043198,GO:0045202,GO:0045211,GO:0048208,GO:2000311" "Golgi membrane|protein binding|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|ER to Golgi transport vesicle membrane|channel regulator activity|dendrite|AMPA glutamate receptor complex|endoplasmic reticulum-Golgi intermediate compartment membrane|synaptic transmission, glutamatergic|regulation of membrane potential|dendritic shaft|synapse|postsynaptic membrane|COPII vesicle coating|regulation of AMPA receptor activity" CNIH4 1454.423535 1405.599155 1503.247915 1.069471271 0.096897728 0.687033733 1 16.883692 17.7544704 29097 cornichon family AMPA receptor auxiliary protein 4 "GO:0005515,GO:0005783,GO:0005789,GO:0005793,GO:0006888,GO:0015031,GO:0016021,GO:0030134,GO:0031730" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|endoplasmic reticulum to Golgi vesicle-mediated transport|protein transport|integral component of membrane|COPII-coated ER to Golgi transport vesicle|CCR5 chemokine receptor binding CNKSR1 34.10594518 37.45489978 30.75699059 0.821174019 -0.284240111 0.710547364 1 0.788520379 0.636677205 10256 connector enhancer of kinase suppressor of Ras 1 "GO:0005515,GO:0005886,GO:0005911,GO:0005938,GO:0007169,GO:0007265,GO:0007266,GO:0030674" protein binding|plasma membrane|cell-cell junction|cell cortex|transmembrane receptor protein tyrosine kinase signaling pathway|Ras protein signal transduction|Rho protein signal transduction|protein-macromolecule adaptor activity CNKSR3 90.03101378 92.59683556 87.465192 0.944580789 -0.082253901 0.888085586 1 0.200834062 0.186529557 154043 CNKSR family member 3 "GO:0005515,GO:0005737,GO:0010765,GO:0016324,GO:0033137,GO:0070373" protein binding|cytoplasm|positive regulation of sodium ion transport|apical plasma membrane|negative regulation of peptidyl-serine phosphorylation|negative regulation of ERK1 and ERK2 cascade CNN1 36.27106129 31.21241648 41.32970611 1.324143106 0.405059049 0.569104845 1 0.691182283 0.899909216 1264 calponin 1 "GO:0003779,GO:0005515,GO:0005516,GO:0005856,GO:0005925,GO:0006940,GO:0031032,GO:1904706" actin binding|protein binding|calmodulin binding|cytoskeleton|focal adhesion|regulation of smooth muscle contraction|actomyosin structure organization|negative regulation of vascular associated smooth muscle cell proliferation CNN2 3348.879819 3349.092288 3348.667351 0.999873119 -0.000183063 1 1 82.02611292 80.64328357 1265 calponin 2 "GO:0001725,GO:0003779,GO:0005516,GO:0005576,GO:0005856,GO:0005911,GO:0005925,GO:0007010,GO:0016020,GO:0031032,GO:0032970,GO:0035580,GO:0035722,GO:0043312,GO:0045296,GO:0071260,GO:1904724" stress fiber|actin binding|calmodulin binding|extracellular region|cytoskeleton|cell-cell junction|focal adhesion|cytoskeleton organization|membrane|actomyosin structure organization|regulation of actin filament-based process|specific granule lumen|interleukin-12-mediated signaling pathway|neutrophil degranulation|cadherin binding|cellular response to mechanical stimulus|tertiary granule lumen CNN3 4920.413353 4334.364235 5506.462472 1.270419875 0.345305388 0.150193143 1 48.30174421 60.33666086 1266 calponin 3 "GO:0003779,GO:0005516,GO:0005829,GO:0005912,GO:0005925,GO:0008017,GO:0014069,GO:0015629,GO:0030855,GO:0031032,GO:0032780,GO:0043025,GO:0043197,GO:0098609,GO:0098641" actin binding|calmodulin binding|cytosol|adherens junction|focal adhesion|microtubule binding|postsynaptic density|actin cytoskeleton|epithelial cell differentiation|actomyosin structure organization|negative regulation of ATPase activity|neuronal cell body|dendritic spine|cell-cell adhesion|cadherin binding involved in cell-cell adhesion CNNM2 1270.912559 1331.72977 1210.095349 0.908664337 -0.138180637 0.567923143 1 4.122982376 3.683716 54805 cyclin and CBS domain divalent metal cation transport mediator 2 "GO:0005524,GO:0005886,GO:0006810,GO:0010960,GO:0015095,GO:0016021,GO:0016323,GO:0022857,GO:0043231,GO:1903830" ATP binding|plasma membrane|transport|magnesium ion homeostasis|magnesium ion transmembrane transporter activity|integral component of membrane|basolateral plasma membrane|transmembrane transporter activity|intracellular membrane-bounded organelle|magnesium ion transmembrane transport CNNM3 372.5492711 444.2567279 300.8418142 0.677180097 -0.562388523 0.056373218 1 3.406978741 2.268531362 26505 cyclin and CBS domain divalent metal cation transport mediator 3 "GO:0005515,GO:0005886,GO:0006810,GO:0006811,GO:0016020,GO:0016021,GO:0022857,GO:0043231,GO:0055085" protein binding|plasma membrane|transport|ion transport|membrane|integral component of membrane|transmembrane transporter activity|intracellular membrane-bounded organelle|transmembrane transport CNNM4 497.4844541 481.7116277 513.2572805 1.065486592 0.091512439 0.743786493 1 4.747564953 4.973820211 26504 cyclin and CBS domain divalent metal cation transport mediator 4 "GO:0005515,GO:0005886,GO:0006810,GO:0007601,GO:0010960,GO:0015081,GO:0015095,GO:0015693,GO:0016021,GO:0016323,GO:0022857,GO:0030425,GO:0032991,GO:0035725,GO:0043025,GO:0043231,GO:0050896,GO:0055065,GO:0070166,GO:1903830" protein binding|plasma membrane|transport|visual perception|magnesium ion homeostasis|sodium ion transmembrane transporter activity|magnesium ion transmembrane transporter activity|magnesium ion transport|integral component of membrane|basolateral plasma membrane|transmembrane transporter activity|dendrite|protein-containing complex|sodium ion transmembrane transport|neuronal cell body|intracellular membrane-bounded organelle|response to stimulus|metal ion homeostasis|enamel mineralization|magnesium ion transmembrane transport CNOT1 7197.543917 7833.276122 6561.811712 0.837684209 -0.255521617 0.296763343 1 47.157084 38.84171967 23019 CCR4-NOT transcription complex subunit 1 "GO:0000122,GO:0000288,GO:0000289,GO:0000932,GO:0001829,GO:0003723,GO:0004535,GO:0005515,GO:0005615,GO:0005634,GO:0005829,GO:0006977,GO:0010606,GO:0016020,GO:0017148,GO:0019904,GO:0030014,GO:0030015,GO:0030331,GO:0033147,GO:0035195,GO:0042974,GO:0048387,GO:0060090,GO:0060213,GO:0061014,GO:0070016,GO:0090503,GO:1900153,GO:2000036" "negative regulation of transcription by RNA polymerase II|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA poly(A) tail shortening|P-body|trophectodermal cell differentiation|RNA binding|poly(A)-specific ribonuclease activity|protein binding|extracellular space|nucleus|cytosol|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|positive regulation of cytoplasmic mRNA processing body assembly|membrane|negative regulation of translation|protein domain specific binding|CCR4-NOT complex|CCR4-NOT core complex|estrogen receptor binding|negative regulation of intracellular estrogen receptor signaling pathway|gene silencing by miRNA|retinoic acid receptor binding|negative regulation of retinoic acid receptor signaling pathway|molecular adaptor activity|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of mRNA catabolic process|armadillo repeat domain binding|RNA phosphodiester bond hydrolysis, exonucleolytic|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|regulation of stem cell population maintenance" hsa03018 RNA degradation CNOT10 903.5949257 923.8875278 883.3023236 0.956071272 -0.064809925 0.797782451 1 15.54419273 14.61267144 25904 CCR4-NOT transcription complex subunit 10 "GO:0000289,GO:0005515,GO:0005634,GO:0005829,GO:0006402,GO:0006977,GO:0016020,GO:0017148,GO:0030014,GO:0031047" "nuclear-transcribed mRNA poly(A) tail shortening|protein binding|nucleus|cytosol|mRNA catabolic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|membrane|negative regulation of translation|CCR4-NOT complex|gene silencing by RNA" hsa03018 RNA degradation CNOT11 1304.667489 1246.415831 1362.919146 1.093470663 0.128914515 0.593684015 1 26.44887559 28.4371146 55571 CCR4-NOT transcription complex subunit 11 "GO:0000289,GO:0003674,GO:0005515,GO:0005634,GO:0005829,GO:0006417,GO:0006977,GO:0030014,GO:0031047" "nuclear-transcribed mRNA poly(A) tail shortening|molecular_function|protein binding|nucleus|cytosol|regulation of translation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|CCR4-NOT complex|gene silencing by RNA" CNOT2 1418.999774 1358.780531 1479.219016 1.088637188 0.122523225 0.61022576 1 14.33115012 15.34035428 4848 CCR4-NOT transcription complex subunit 2 "GO:0000122,GO:0000289,GO:0000932,GO:0001226,GO:0001829,GO:0003712,GO:0004535,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006357,GO:0006417,GO:0006977,GO:0010606,GO:0016020,GO:0030014,GO:0030015,GO:0031047,GO:0033147,GO:0090503,GO:2000036" "negative regulation of transcription by RNA polymerase II|nuclear-transcribed mRNA poly(A) tail shortening|P-body|RNA polymerase II transcription corepressor binding|trophectodermal cell differentiation|transcription coregulator activity|poly(A)-specific ribonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|regulation of translation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|positive regulation of cytoplasmic mRNA processing body assembly|membrane|CCR4-NOT complex|CCR4-NOT core complex|gene silencing by RNA|negative regulation of intracellular estrogen receptor signaling pathway|RNA phosphodiester bond hydrolysis, exonucleolytic|regulation of stem cell population maintenance" hsa03018 RNA degradation CNOT3 916.8775019 957.180772 876.5742319 0.915787548 -0.126915147 0.61096601 1 13.72829309 12.36182112 4849 CCR4-NOT transcription complex subunit 3 "GO:0000289,GO:0000932,GO:0001829,GO:0005515,GO:0005634,GO:0005829,GO:0006355,GO:0006417,GO:0006977,GO:0030014,GO:0030015,GO:0031047,GO:0120162,GO:2000036" "nuclear-transcribed mRNA poly(A) tail shortening|P-body|trophectodermal cell differentiation|protein binding|nucleus|cytosol|regulation of transcription, DNA-templated|regulation of translation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|CCR4-NOT complex|CCR4-NOT core complex|gene silencing by RNA|positive regulation of cold-induced thermogenesis|regulation of stem cell population maintenance" hsa03018 RNA degradation CNOT4 431.3829596 436.9738307 425.7920885 0.974410957 -0.037397739 0.903346831 1 4.268806557 4.08996708 4850 CCR4-NOT transcription complex subunit 4 "GO:0000289,GO:0003723,GO:0004842,GO:0005515,GO:0005634,GO:0005829,GO:0006511,GO:0006977,GO:0016567,GO:0030014,GO:0045652,GO:0046872,GO:0051865" "nuclear-transcribed mRNA poly(A) tail shortening|RNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|cytosol|ubiquitin-dependent protein catabolic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|protein ubiquitination|CCR4-NOT complex|regulation of megakaryocyte differentiation|metal ion binding|protein autoubiquitination" hsa03018 RNA degradation CNOT6 1467.428709 1431.609503 1503.247915 1.05004047 0.070444933 0.770335179 1 11.26878584 11.63467728 57472 CCR4-NOT transcription complex subunit 6 "GO:0000175,GO:0000289,GO:0003723,GO:0004532,GO:0004535,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006417,GO:0006977,GO:0008284,GO:0010606,GO:0016020,GO:0030014,GO:0030374,GO:0035195,GO:0043928,GO:0045893,GO:0046872,GO:0070966,GO:0090503" "3'-5'-exoribonuclease activity|nuclear-transcribed mRNA poly(A) tail shortening|RNA binding|exoribonuclease activity|poly(A)-specific ribonuclease activity|protein binding|nucleus|cytoplasm|cytosol|regulation of translation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|positive regulation of cell population proliferation|positive regulation of cytoplasmic mRNA processing body assembly|membrane|CCR4-NOT complex|nuclear receptor coactivator activity|gene silencing by miRNA|exonucleolytic catabolism of deadenylated mRNA|positive regulation of transcription, DNA-templated|metal ion binding|nuclear-transcribed mRNA catabolic process, no-go decay|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation CNOT6L 884.2780718 858.3414532 910.2146903 1.060434268 0.084655196 0.737084387 1 4.410562853 4.598846854 246175 CCR4-NOT transcription complex subunit 6 like "GO:0000175,GO:0000289,GO:0004535,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006397,GO:0006977,GO:0008284,GO:0010606,GO:0030014,GO:0031047,GO:0046872,GO:0061157,GO:0090503" "3'-5'-exoribonuclease activity|nuclear-transcribed mRNA poly(A) tail shortening|poly(A)-specific ribonuclease activity|protein binding|nucleus|cytoplasm|cytosol|mRNA processing|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|positive regulation of cell population proliferation|positive regulation of cytoplasmic mRNA processing body assembly|CCR4-NOT complex|gene silencing by RNA|metal ion binding|mRNA destabilization|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation CNOT7 1756.432868 1688.591732 1824.274004 1.080352326 0.111501883 0.63968204 1 7.887015334 8.378172059 29883 CCR4-NOT transcription complex subunit 7 "GO:0000175,GO:0000289,GO:0000290,GO:0000932,GO:0003714,GO:0003723,GO:0004532,GO:0004535,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006977,GO:0008134,GO:0008284,GO:0008285,GO:0010629,GO:0016020,GO:0016604,GO:0016607,GO:0017148,GO:0030014,GO:0030015,GO:0031047,GO:0033962,GO:0035195,GO:0042509,GO:0043928,GO:0045070,GO:0045892,GO:0045944,GO:0046872,GO:0051607,GO:0060213,GO:0060339,GO:0061014,GO:0090503,GO:1900153" "3'-5'-exoribonuclease activity|nuclear-transcribed mRNA poly(A) tail shortening|deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|transcription corepressor activity|RNA binding|exoribonuclease activity|poly(A)-specific ribonuclease activity|protein binding|nucleus|cytoplasm|cytosol|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|transcription factor binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|negative regulation of gene expression|membrane|nuclear body|nuclear speck|negative regulation of translation|CCR4-NOT complex|CCR4-NOT core complex|gene silencing by RNA|P-body assembly|gene silencing by miRNA|regulation of tyrosine phosphorylation of STAT protein|exonucleolytic catabolism of deadenylated mRNA|positive regulation of viral genome replication|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|defense response to virus|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|negative regulation of type I interferon-mediated signaling pathway|positive regulation of mRNA catabolic process|RNA phosphodiester bond hydrolysis, exonucleolytic|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" hsa03018 RNA degradation CNOT8 2066.349715 1926.846511 2205.852919 1.144799498 0.195094945 0.409860701 1 28.4067008 31.97579905 9337 CCR4-NOT transcription complex subunit 8 "GO:0000175,GO:0000289,GO:0000932,GO:0003723,GO:0004535,GO:0005515,GO:0005634,GO:0005829,GO:0006351,GO:0006977,GO:0008284,GO:0017148,GO:0030014,GO:0030015,GO:0035195,GO:0043928,GO:0046872,GO:0061014,GO:0090503" "3'-5'-exoribonuclease activity|nuclear-transcribed mRNA poly(A) tail shortening|P-body|RNA binding|poly(A)-specific ribonuclease activity|protein binding|nucleus|cytosol|transcription, DNA-templated|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|positive regulation of cell population proliferation|negative regulation of translation|CCR4-NOT complex|CCR4-NOT core complex|gene silencing by miRNA|exonucleolytic catabolism of deadenylated mRNA|metal ion binding|positive regulation of mRNA catabolic process|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation CNOT9 1784.068003 1783.269395 1784.86661 1.000895667 0.001291596 0.998381871 1 19.19907406 18.89471178 9125 CCR4-NOT transcription complex subunit 9 "GO:0000289,GO:0000932,GO:0005154,GO:0005515,GO:0005634,GO:0005829,GO:0006977,GO:0007548,GO:0016020,GO:0017148,GO:0019221,GO:0019900,GO:0019904,GO:0030014,GO:0030015,GO:0030374,GO:0031047,GO:0032991,GO:0033138,GO:0033147,GO:0042803,GO:0045742,GO:0045893" "nuclear-transcribed mRNA poly(A) tail shortening|P-body|epidermal growth factor receptor binding|protein binding|nucleus|cytosol|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|sex differentiation|membrane|negative regulation of translation|cytokine-mediated signaling pathway|kinase binding|protein domain specific binding|CCR4-NOT complex|CCR4-NOT core complex|nuclear receptor coactivator activity|gene silencing by RNA|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|negative regulation of intracellular estrogen receptor signaling pathway|protein homodimerization activity|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of transcription, DNA-templated" hsa03018 RNA degradation CNP 1549.849119 1627.207312 1472.490925 0.904919068 -0.144139325 0.546300538 1 15.91953503 14.16482773 1267 "2',3'-cyclic nucleotide 3' phosphodiesterase" "GO:0000226,GO:0003723,GO:0004113,GO:0005515,GO:0005615,GO:0005737,GO:0005741,GO:0005743,GO:0005886,GO:0005902,GO:0007268,GO:0007409,GO:0007568,GO:0008344,GO:0009214,GO:0009636,GO:0016020,GO:0021762,GO:0030551,GO:0030900,GO:0031143,GO:0032496,GO:0035748,GO:0035749,GO:0042470,GO:0045202,GO:0046902,GO:0048471,GO:0048709,GO:0070062" "microtubule cytoskeleton organization|RNA binding|2',3'-cyclic-nucleotide 3'-phosphodiesterase activity|protein binding|extracellular space|cytoplasm|mitochondrial outer membrane|mitochondrial inner membrane|plasma membrane|microvillus|chemical synaptic transmission|axonogenesis|aging|adult locomotory behavior|cyclic nucleotide catabolic process|response to toxic substance|membrane|substantia nigra development|cyclic nucleotide binding|forebrain development|pseudopodium|response to lipopolysaccharide|myelin sheath abaxonal region|myelin sheath adaxonal region|melanosome|synapse|regulation of mitochondrial membrane permeability|perinuclear region of cytoplasm|oligodendrocyte differentiation|extracellular exosome" CNPPD1 812.2957851 797.997448 826.5941222 1.035835546 0.050794972 0.844281581 1 16.67488533 16.98340808 27013 cyclin Pas1/PHO80 domain containing 1 "GO:0000079,GO:0000307,GO:0005634,GO:0016021,GO:0016538,GO:0019901" regulation of cyclin-dependent protein serine/threonine kinase activity|cyclin-dependent protein kinase holoenzyme complex|nucleus|integral component of membrane|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding CNPY2 1286.717527 1267.224109 1306.210944 1.030765541 0.043716213 0.858989932 1 31.25204327 31.6744795 10330 canopy FGF signaling regulator 2 "GO:0005515,GO:0005783,GO:0010629,GO:0010988,GO:1905599" protein binding|endoplasmic reticulum|negative regulation of gene expression|regulation of low-density lipoprotein particle clearance|positive regulation of low-density lipoprotein receptor activity CNPY3 514.6714048 466.1054194 563.2373902 1.208390563 0.273086822 0.315601909 1 9.660267794 11.47803829 10695 canopy FGF signaling regulator 3 "GO:0002224,GO:0005102,GO:0005515,GO:0005788,GO:0045087" toll-like receptor signaling pathway|signaling receptor binding|protein binding|endoplasmic reticulum lumen|innate immune response CNPY4 385.1933679 372.46817 397.9185658 1.068329049 0.09535607 0.751261069 1 13.44921628 14.12775626 245812 canopy FGF signaling regulator 4 "GO:0003674,GO:0005102,GO:0005515,GO:0005576,GO:1903078" molecular_function|signaling receptor binding|protein binding|extracellular region|positive regulation of protein localization to plasma membrane CNRIP1 140.461519 167.5066351 113.4164028 0.677086031 -0.562588939 0.175903649 1 4.04503224 2.693004135 25927 cannabinoid receptor interacting protein 1 "GO:0005515,GO:0005737,GO:0005886,GO:0008022,GO:0031718,GO:2000272" protein binding|cytoplasm|plasma membrane|protein C-terminus binding|type 1 cannabinoid receptor binding|negative regulation of signaling receptor activity CNST 975.0022852 1019.605605 930.3989654 0.912508681 -0.132089812 0.593980439 1 9.383424243 8.419174969 163882 "consortin, connexin sorting protein" "GO:0005515,GO:0005802,GO:0005886,GO:0010923,GO:0016020,GO:0016021,GO:0019902,GO:0030133,GO:0032991,GO:0042998,GO:0043231,GO:0071253" protein binding|trans-Golgi network|plasma membrane|negative regulation of phosphatase activity|membrane|integral component of membrane|phosphatase binding|transport vesicle|protein-containing complex|positive regulation of Golgi to plasma membrane protein transport|intracellular membrane-bounded organelle|connexin binding CNTD1 2.40288989 0 4.80577978 Inf Inf 0.18976424 1 0 0.075077065 124817 cyclin N-terminal domain containing 1 "GO:0007131,GO:0007283,GO:0035861" reciprocal meiotic recombination|spermatogenesis|site of double-strand break CNTF 25.61908785 29.13158871 22.10658699 0.758852777 -0.398108076 0.63496867 1 0.817402391 0.609908393 1270 ciliary neurotrophic factor "GO:0005125,GO:0005127,GO:0005138,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0007165,GO:0008083,GO:0008284,GO:0010628,GO:0019221,GO:0030424,GO:0042531,GO:0043524,GO:0044877,GO:0046533,GO:0046668,GO:0048143,GO:0048644,GO:0048666,GO:0048680,GO:0070120" cytokine activity|ciliary neurotrophic factor receptor binding|interleukin-6 receptor binding|protein binding|extracellular region|extracellular space|cytoplasm|signal transduction|growth factor activity|positive regulation of cell population proliferation|positive regulation of gene expression|cytokine-mediated signaling pathway|axon|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of neuron apoptotic process|protein-containing complex binding|negative regulation of photoreceptor cell differentiation|regulation of retinal cell programmed cell death|astrocyte activation|muscle organ morphogenesis|neuron development|positive regulation of axon regeneration|ciliary neurotrophic factor-mediated signaling pathway "hsa04060,hsa04630" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway CNTFR 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.052217846 0.0158109 1271 ciliary neurotrophic factor receptor "GO:0001967,GO:0003360,GO:0004896,GO:0004897,GO:0005102,GO:0005515,GO:0005886,GO:0007165,GO:0007399,GO:0007548,GO:0008284,GO:0009897,GO:0016324,GO:0019221,GO:0019898,GO:0019955,GO:0031225,GO:0043235,GO:0043524,GO:0060538,GO:0070110,GO:0070120,GO:0097059" suckling behavior|brainstem development|cytokine receptor activity|ciliary neurotrophic factor receptor activity|signaling receptor binding|protein binding|plasma membrane|signal transduction|nervous system development|sex differentiation|positive regulation of cell population proliferation|external side of plasma membrane|apical plasma membrane|cytokine-mediated signaling pathway|extrinsic component of membrane|cytokine binding|anchored component of membrane|receptor complex|negative regulation of neuron apoptotic process|skeletal muscle organ development|ciliary neurotrophic factor receptor complex|ciliary neurotrophic factor-mediated signaling pathway|CNTFR-CLCF1 complex "hsa04060,hsa04630" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway CNTLN 349.2839977 338.1345119 360.4334835 1.065947044 0.092135768 0.766975055 1 1.230522839 1.289723126 54875 centlein "GO:0005654,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0010457,GO:0019901,GO:0019904,GO:0030674,GO:0033365,GO:0070062" nucleoplasm|cytoplasm|centrosome|centriole|cytosol|centriole-centriole cohesion|protein kinase binding|protein domain specific binding|protein-macromolecule adaptor activity|protein localization to organelle|extracellular exosome CNTN5 12.89131706 10.40413883 15.3784953 1.478113235 0.563756795 0.626027011 1 0.077225281 0.112237602 53942 contactin 5 "GO:0005576,GO:0005886,GO:0007155,GO:0007605,GO:0098982,GO:0099026,GO:0099054" extracellular region|plasma membrane|cell adhesion|sensory perception of sound|GABA-ergic synapse|anchored component of presynaptic membrane|presynapse assembly CNTN6 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.008862726 0.032202249 27255 contactin 6 "GO:0005886,GO:0007155,GO:0007156,GO:0007219,GO:0007411,GO:0007417,GO:0030424,GO:0045747,GO:0070593,GO:0098632,GO:0098688,GO:0099026" plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|Notch signaling pathway|axon guidance|central nervous system development|axon|positive regulation of Notch signaling pathway|dendrite self-avoidance|cell-cell adhesion mediator activity|parallel fiber to Purkinje cell synapse|anchored component of presynaptic membrane CNTNAP1 1624.828115 1804.077673 1445.578558 0.801283991 -0.319614441 0.178977338 1 11.27536124 8.883581875 8506 contactin associated protein 1 "GO:0002175,GO:0005515,GO:0005887,GO:0007010,GO:0007155,GO:0007165,GO:0016021,GO:0017124,GO:0019227,GO:0022010,GO:0022011,GO:0030913,GO:0033010,GO:0033270,GO:0038023,GO:0048787,GO:0048812,GO:0050884,GO:0050885,GO:0071205" protein localization to paranode region of axon|protein binding|integral component of plasma membrane|cytoskeleton organization|cell adhesion|signal transduction|integral component of membrane|SH3 domain binding|neuronal action potential propagation|central nervous system myelination|myelination in peripheral nervous system|paranodal junction assembly|paranodal junction|paranode region of axon|signaling receptor activity|presynaptic active zone membrane|neuron projection morphogenesis|neuromuscular process controlling posture|neuromuscular process controlling balance|protein localization to juxtaparanode region of axon hsa04514 Cell adhesion molecules CNTNAP2 7.887392465 5.202069413 10.57271552 2.032405698 1.023188414 0.464422034 1 0.027210123 0.054376605 26047 contactin associated protein 2 "GO:0005515,GO:0005769,GO:0005794,GO:0007155,GO:0007420,GO:0007612,GO:0008038,GO:0008076,GO:0009986,GO:0016020,GO:0016021,GO:0019226,GO:0019899,GO:0021756,GO:0021761,GO:0021794,GO:0021987,GO:0030424,GO:0030425,GO:0030534,GO:0030673,GO:0031175,GO:0033010,GO:0035176,GO:0042297,GO:0043025,GO:0043204,GO:0044224,GO:0045163,GO:0048812,GO:0071109,GO:0071205,GO:0071625" protein binding|early endosome|Golgi apparatus|cell adhesion|brain development|learning|neuron recognition|voltage-gated potassium channel complex|cell surface|membrane|integral component of membrane|transmission of nerve impulse|enzyme binding|striatum development|limbic system development|thalamus development|cerebral cortex development|axon|dendrite|adult behavior|axolemma|neuron projection development|paranodal junction|social behavior|vocal learning|neuronal cell body|perikaryon|juxtaparanode region of axon|clustering of voltage-gated potassium channels|neuron projection morphogenesis|superior temporal gyrus development|protein localization to juxtaparanode region of axon|vocalization behavior hsa04514 Cell adhesion molecules CNTNAP3 89.58503434 106.122216 73.04785266 0.688337046 -0.538812938 0.269784936 1 0.430688032 0.291497696 79937 contactin associated protein family member 3 "GO:0005576,GO:0005886,GO:0007155,GO:0008037,GO:0016021" extracellular region|plasma membrane|cell adhesion|cell recognition|integral component of membrane CNTNAP3B 20.57553429 22.88910542 18.26196316 0.797845212 -0.325819215 0.74151566 1 0.159637936 0.125235059 728577 contactin associated protein family member 3B "GO:0007155,GO:0016021" cell adhesion|integral component of membrane CNTNAP3C 12.97057499 12.48496659 13.45618338 1.0777909 0.108077311 1 1 0.138696861 0.146984765 100289279 CNTRL 1052.002973 1148.616926 955.3890203 0.831773412 -0.265737525 0.277773877 1 7.359775999 6.019228206 11064 centriolin "GO:0000086,GO:0001822,GO:0003281,GO:0005515,GO:0005813,GO:0005815,GO:0005829,GO:0008092,GO:0010389,GO:0016020,GO:0035904,GO:0048471,GO:0051301,GO:0051493,GO:0060976,GO:0090543,GO:0090619,GO:0097431,GO:0097711,GO:0120103" G2/M transition of mitotic cell cycle|kidney development|ventricular septum development|protein binding|centrosome|microtubule organizing center|cytosol|cytoskeletal protein binding|regulation of G2/M transition of mitotic cell cycle|membrane|aorta development|perinuclear region of cytoplasm|cell division|regulation of cytoskeleton organization|coronary vasculature development|Flemming body|meiotic spindle pole|mitotic spindle pole|ciliary basal body-plasma membrane docking|centriolar subdistal appendage CNTROB 975.8049253 1015.443949 936.1659011 0.921927696 -0.117274485 0.636450814 1 12.8387532 11.63833601 116840 "centrobin, centriole duplication and spindle assembly protein" "GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0007099,GO:0019904,GO:0051299,GO:1902017,GO:1902410" protein binding|centrosome|centriole|cytosol|centriole replication|protein domain specific binding|centrosome separation|regulation of cilium assembly|mitotic cytokinetic process COA1 1954.067461 1994.473413 1913.661508 0.959482085 -0.059672226 0.802724926 1 7.593734777 7.164130254 55744 cytochrome c oxidase assembly factor 1 homolog "GO:0005739,GO:0005829,GO:0031305,GO:0032981,GO:0033617" mitochondrion|cytosol|integral component of mitochondrial inner membrane|mitochondrial respiratory chain complex I assembly|mitochondrial cytochrome c oxidase assembly hsa04714 Thermogenesis COA3 501.690769 478.590386 524.791152 1.09653509 0.13295198 0.630776371 1 32.74549909 35.30574065 28958 cytochrome c oxidase assembly factor 3 "GO:0005515,GO:0005739,GO:0031305,GO:0033617,GO:0070131" protein binding|mitochondrion|integral component of mitochondrial inner membrane|mitochondrial cytochrome c oxidase assembly|positive regulation of mitochondrial translation hsa04714 Thermogenesis COA4 792.0423129 770.946687 813.1379388 1.054726549 0.076869011 0.764305348 1 11.03352313 11.44261449 51287 cytochrome c oxidase assembly factor 4 homolog "GO:0005739,GO:0005758,GO:0033617" mitochondrion|mitochondrial intermembrane space|mitochondrial cytochrome c oxidase assembly hsa04714 Thermogenesis COA5 358.6628139 319.407062 397.9185658 1.245803907 0.317077002 0.288885852 1 9.630603306 11.79707557 493753 cytochrome c oxidase assembly factor 5 "GO:0005515,GO:0005739,GO:0033617" protein binding|mitochondrion|mitochondrial cytochrome c oxidase assembly hsa04714 Thermogenesis COA6 337.799816 314.2049926 361.3946395 1.150187451 0.201869002 0.510082663 1 13.34012965 15.08689452 388753 cytochrome c oxidase assembly factor 6 "GO:0003723,GO:0005507,GO:0005515,GO:0005654,GO:0005739,GO:0005758,GO:0005886,GO:0008535,GO:0042774,GO:0045277" RNA binding|copper ion binding|protein binding|nucleoplasm|mitochondrion|mitochondrial intermembrane space|plasma membrane|respiratory chain complex IV assembly|plasma membrane ATP synthesis coupled electron transport|respiratory chain complex IV hsa04714 Thermogenesis COA7 586.7864409 693.9560597 479.616822 0.691134281 -0.532962056 0.043484305 1 9.286649817 6.310920112 65260 cytochrome c oxidase assembly factor 7 "GO:0005515,GO:0005654,GO:0005739,GO:0005758" protein binding|nucleoplasm|mitochondrion|mitochondrial intermembrane space hsa04714 Thermogenesis COA8 577.9039083 574.3084632 581.4993534 1.012520955 0.017951765 0.953105772 1 18.37517215 18.29391324 84334 cytochrome c oxidase assembly factor 8 "GO:0000302,GO:0005739,GO:0033617,GO:0050821,GO:0097193,GO:0099617,GO:1903427,GO:1904960" response to reactive oxygen species|mitochondrion|mitochondrial cytochrome c oxidase assembly|protein stabilization|intrinsic apoptotic signaling pathway|matrix side of mitochondrial inner membrane|negative regulation of reactive oxygen species biosynthetic process|positive regulation of cytochrome-c oxidase activity COASY 1801.091407 1775.986498 1826.196316 1.028271509 0.04022125 0.867490883 1 40.24676656 40.6920881 80347 Coenzyme A synthase "GO:0004140,GO:0004595,GO:0005515,GO:0005524,GO:0005741,GO:0005759,GO:0015937,GO:0016310,GO:0070062" dephospho-CoA kinase activity|pantetheine-phosphate adenylyltransferase activity|protein binding|ATP binding|mitochondrial outer membrane|mitochondrial matrix|coenzyme A biosynthetic process|phosphorylation|extracellular exosome hsa00770 Pantothenate and CoA biosynthesis COBLL1 436.6397492 410.9634836 462.3160148 1.124956433 0.169869131 0.551611437 1 2.103824058 2.327106715 22837 cordon-bleu WH2 repeat protein like 1 "GO:0003785,GO:0045296,GO:0070062" actin monomer binding|cadherin binding|extracellular exosome COCH 1008.840888 1024.807674 992.8741025 0.968839449 -0.045670485 0.856267658 1 20.5919059 19.61641033 1690 cochlin "GO:0005515,GO:0005518,GO:0007605,GO:0008360,GO:0042742,GO:0045089,GO:0062023" protein binding|collagen binding|sensory perception of sound|regulation of cell shape|defense response to bacterium|positive regulation of innate immune response|collagen-containing extracellular matrix COG1 1698.852829 1665.702626 1732.003033 1.039803267 0.056310593 0.814676483 1 29.49418969 30.15496476 9382 component of oligomeric golgi complex 1 "GO:0000139,GO:0005515,GO:0005794,GO:0006888,GO:0006891,GO:0007030,GO:0015031,GO:0017119,GO:0032588" Golgi membrane|protein binding|Golgi apparatus|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|Golgi organization|protein transport|Golgi transport complex|trans-Golgi network membrane COG2 479.7376674 495.2370081 464.2383267 0.937406371 -0.093253494 0.741236885 1 9.014286807 8.308649744 22796 component of oligomeric golgi complex 2 "GO:0000139,GO:0005515,GO:0005795,GO:0005829,GO:0006888,GO:0006891,GO:0007030,GO:0015031,GO:0017119,GO:0032588,GO:0044877" Golgi membrane|protein binding|Golgi stack|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|Golgi organization|protein transport|Golgi transport complex|trans-Golgi network membrane|protein-containing complex binding COG3 1052.904993 1096.596232 1009.213754 0.920314811 -0.119800649 0.626581567 1 12.99940592 11.76335206 83548 component of oligomeric golgi complex 3 "GO:0000139,GO:0005515,GO:0005794,GO:0005801,GO:0005829,GO:0005886,GO:0006486,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0007030,GO:0017119,GO:0032580,GO:0032588,GO:0033365,GO:0050821" "Golgi membrane|protein binding|Golgi apparatus|cis-Golgi network|cytosol|plasma membrane|protein glycosylation|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|Golgi organization|Golgi transport complex|Golgi cisterna membrane|trans-Golgi network membrane|protein localization to organelle|protein stabilization" COG4 1188.521718 1162.142307 1214.901128 1.045397901 0.064052168 0.794416249 1 20.69449416 21.27196539 25839 component of oligomeric golgi complex 4 "GO:0000139,GO:0005515,GO:0005829,GO:0006888,GO:0006890,GO:0007030,GO:0015031,GO:0017119,GO:0032588,GO:0048213" "Golgi membrane|protein binding|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|protein transport|Golgi transport complex|trans-Golgi network membrane|Golgi vesicle prefusion complex stabilization" COG5 2283.767877 2133.888873 2433.646881 1.140474985 0.189634803 0.422770295 1 12.55863776 14.08313935 10466 component of oligomeric golgi complex 5 "GO:0000139,GO:0003674,GO:0005515,GO:0005654,GO:0005794,GO:0005829,GO:0006888,GO:0006891,GO:0015031,GO:0016020,GO:0017119,GO:0032588,GO:0048219" Golgi membrane|molecular_function|protein binding|nucleoplasm|Golgi apparatus|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|protein transport|membrane|Golgi transport complex|trans-Golgi network membrane|inter-Golgi cisterna vesicle-mediated transport COG6 1264.07687 1101.798302 1426.355439 1.294570373 0.372473393 0.12251015 1 8.351221466 10.63033237 57511 component of oligomeric golgi complex 6 "GO:0000139,GO:0005515,GO:0006888,GO:0006891,GO:0015031,GO:0017119,GO:0032588,GO:0070085" Golgi membrane|protein binding|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|protein transport|Golgi transport complex|trans-Golgi network membrane|glycosylation COG7 421.3801408 414.0847253 428.6755564 1.035236342 0.049960169 0.869038261 1 7.322379302 7.453545551 91949 component of oligomeric golgi complex 7 "GO:0000139,GO:0005515,GO:0005730,GO:0005794,GO:0006486,GO:0006886,GO:0006888,GO:0006890,GO:0007030,GO:0017119,GO:0032588,GO:0033365,GO:0034067,GO:0043231,GO:0050821" "Golgi membrane|protein binding|nucleolus|Golgi apparatus|protein glycosylation|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|Golgi transport complex|trans-Golgi network membrane|protein localization to organelle|protein localization to Golgi apparatus|intracellular membrane-bounded organelle|protein stabilization" COG8 529.1774485 544.1364606 514.2184365 0.945017424 -0.081587165 0.768031665 1 5.921607427 5.502380345 84342 component of oligomeric golgi complex 8 "GO:0000139,GO:0005515,GO:0005794,GO:0006888,GO:0006891,GO:0015031,GO:0016020,GO:0017119,GO:0032588" Golgi membrane|protein binding|Golgi apparatus|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|protein transport|membrane|Golgi transport complex|trans-Golgi network membrane COIL 405.714182 431.7717613 379.6566026 0.879299289 -0.185573793 0.523051056 1 8.748240447 7.563601018 8161 coilin "GO:0000387,GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0008022,GO:0015030,GO:0016020,GO:0016604,GO:0030619,GO:0030620,GO:0042802" spliceosomal snRNP assembly|fibrillar center|protein binding|nucleus|nucleoplasm|nucleolus|protein C-terminus binding|Cajal body|membrane|nuclear body|U1 snRNA binding|U2 snRNA binding|identical protein binding COL11A1 2.561405743 4.161655531 0.961155956 0.230955193 -2.11431511 0.482263142 1 0.027291706 0.006197686 1301 collagen type XI alpha 1 chain "GO:0001502,GO:0001503,GO:0002063,GO:0005201,GO:0005576,GO:0005592,GO:0005615,GO:0005788,GO:0006029,GO:0007601,GO:0007605,GO:0008201,GO:0030020,GO:0030198,GO:0030199,GO:0030674,GO:0031012,GO:0035987,GO:0035989,GO:0042472,GO:0046872,GO:0048704,GO:0050840,GO:0050910,GO:0055010,GO:0062023,GO:1904399" cartilage condensation|ossification|chondrocyte development|extracellular matrix structural constituent|extracellular region|collagen type XI trimer|extracellular space|endoplasmic reticulum lumen|proteoglycan metabolic process|visual perception|sensory perception of sound|heparin binding|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|collagen fibril organization|protein-macromolecule adaptor activity|extracellular matrix|endodermal cell differentiation|tendon development|inner ear morphogenesis|metal ion binding|embryonic skeletal system morphogenesis|extracellular matrix binding|detection of mechanical stimulus involved in sensory perception of sound|ventricular cardiac muscle tissue morphogenesis|collagen-containing extracellular matrix|heparan sulfate binding hsa04974 Protein digestion and absorption COL11A2 15.13066068 18.72744989 11.53387147 0.615880514 -0.699277611 0.488765132 1 0.116377455 0.070475229 1302 collagen type XI alpha 2 chain "GO:0001501,GO:0005201,GO:0005515,GO:0005576,GO:0005581,GO:0005592,GO:0005615,GO:0005788,GO:0007605,GO:0030020,GO:0030198,GO:0030199,GO:0030674,GO:0031012,GO:0046872,GO:0051216,GO:0060021,GO:0060023,GO:0062023" skeletal system development|extracellular matrix structural constituent|protein binding|extracellular region|collagen trimer|collagen type XI trimer|extracellular space|endoplasmic reticulum lumen|sensory perception of sound|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|collagen fibril organization|protein-macromolecule adaptor activity|extracellular matrix|metal ion binding|cartilage development|roof of mouth development|soft palate development|collagen-containing extracellular matrix hsa04974 Protein digestion and absorption COL12A1 4907.752438 5541.244339 4274.260536 0.771353919 -0.374535134 0.118592129 1 25.11686988 19.04979843 1303 collagen type XII alpha 1 chain "GO:0005576,GO:0005595,GO:0005615,GO:0005788,GO:0007155,GO:0030020,GO:0030199,GO:0035987,GO:0062023,GO:0070062,GO:1903561" extracellular region|collagen type XII trimer|extracellular space|endoplasmic reticulum lumen|cell adhesion|extracellular matrix structural constituent conferring tensile strength|collagen fibril organization|endodermal cell differentiation|collagen-containing extracellular matrix|extracellular exosome|extracellular vesicle hsa04974 Protein digestion and absorption COL13A1 1037.092422 782.3912397 1291.793605 1.651083932 0.723413461 0.003247205 0.367925679 12.12744191 19.68835959 1305 collagen type XIII alpha 1 chain "GO:0001501,GO:0001763,GO:0001958,GO:0005201,GO:0005515,GO:0005576,GO:0005581,GO:0005600,GO:0005615,GO:0005788,GO:0005886,GO:0005911,GO:0007160,GO:0008201,GO:0030020,GO:0030154,GO:0030198,GO:0030199,GO:0030574,GO:0030903,GO:0031012,GO:0045211,GO:0062023,GO:0098609" skeletal system development|morphogenesis of a branching structure|endochondral ossification|extracellular matrix structural constituent|protein binding|extracellular region|collagen trimer|collagen type XIII trimer|extracellular space|endoplasmic reticulum lumen|plasma membrane|cell-cell junction|cell-matrix adhesion|heparin binding|extracellular matrix structural constituent conferring tensile strength|cell differentiation|extracellular matrix organization|collagen fibril organization|collagen catabolic process|notochord development|extracellular matrix|postsynaptic membrane|collagen-containing extracellular matrix|cell-cell adhesion hsa04974 Protein digestion and absorption COL16A1 165.5157405 207.0423626 123.9891183 0.598858691 -0.739712475 0.058233938 1 1.800761142 1.060355873 1307 collagen type XVI alpha 1 chain "GO:0005178,GO:0005201,GO:0005515,GO:0005576,GO:0005588,GO:0005597,GO:0005615,GO:0005788,GO:0007155,GO:0007229,GO:0007565,GO:0030020,GO:0030198,GO:0031012,GO:0033622,GO:0033627,GO:0051894,GO:0062023,GO:0071230" integrin binding|extracellular matrix structural constituent|protein binding|extracellular region|collagen type V trimer|collagen type XVI trimer|extracellular space|endoplasmic reticulum lumen|cell adhesion|integrin-mediated signaling pathway|female pregnancy|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|integrin activation|cell adhesion mediated by integrin|positive regulation of focal adhesion assembly|collagen-containing extracellular matrix|cellular response to amino acid stimulus hsa04974 Protein digestion and absorption COL17A1 510.0140801 495.2370081 524.791152 1.059676768 0.083624268 0.764423274 1 4.709531168 4.907070155 1308 collagen type XVII alpha 1 chain "GO:0005201,GO:0005515,GO:0005576,GO:0005581,GO:0005604,GO:0005615,GO:0005788,GO:0005886,GO:0005887,GO:0005911,GO:0007160,GO:0008544,GO:0030020,GO:0030056,GO:0030198,GO:0031012,GO:0031581,GO:0050776,GO:0062023" extracellular matrix structural constituent|protein binding|extracellular region|collagen trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|plasma membrane|integral component of plasma membrane|cell-cell junction|cell-matrix adhesion|epidermis development|extracellular matrix structural constituent conferring tensile strength|hemidesmosome|extracellular matrix organization|extracellular matrix|hemidesmosome assembly|regulation of immune response|collagen-containing extracellular matrix hsa04974 Protein digestion and absorption COL18A1 2354.390875 2486.58918 2222.19257 0.893670972 -0.16218433 0.493084721 1 21.88762895 19.23302288 80781 collagen type XVIII alpha 1 chain "GO:0001525,GO:0001886,GO:0005201,GO:0005576,GO:0005581,GO:0005604,GO:0005615,GO:0005788,GO:0007155,GO:0007601,GO:0008285,GO:0009887,GO:0030020,GO:0030198,GO:0031012,GO:0042493,GO:0046872,GO:0051599,GO:0062023,GO:0070062" angiogenesis|endothelial cell morphogenesis|extracellular matrix structural constituent|extracellular region|collagen trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|cell adhesion|visual perception|negative regulation of cell population proliferation|animal organ morphogenesis|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|response to drug|metal ion binding|response to hydrostatic pressure|collagen-containing extracellular matrix|extracellular exosome hsa04974 Protein digestion and absorption COL1A1 163.851324 163.3449796 164.3576685 1.006199694 0.008916656 0.999854545 1 1.472786171 1.45711912 1277 collagen type I alpha 1 chain "GO:0001501,GO:0001503,GO:0001568,GO:0001649,GO:0001957,GO:0001958,GO:0002020,GO:0005201,GO:0005515,GO:0005576,GO:0005584,GO:0005615,GO:0005737,GO:0005788,GO:0005794,GO:0007596,GO:0007601,GO:0007605,GO:0009612,GO:0010718,GO:0010812,GO:0015031,GO:0030020,GO:0030141,GO:0030168,GO:0030198,GO:0030199,GO:0030335,GO:0031012,GO:0031960,GO:0032355,GO:0032964,GO:0034504,GO:0034505,GO:0038063,GO:0042493,GO:0042542,GO:0042802,GO:0043434,GO:0043588,GO:0043589,GO:0044344,GO:0044691,GO:0045893,GO:0046872,GO:0048407,GO:0048706,GO:0050776,GO:0050900,GO:0051591,GO:0055093,GO:0060325,GO:0060346,GO:0060351,GO:0062023,GO:0071230,GO:0071260,GO:0071300,GO:0071306,GO:0071356,GO:0071364,GO:0071560,GO:0090263,GO:1902618" "skeletal system development|ossification|blood vessel development|osteoblast differentiation|intramembranous ossification|endochondral ossification|protease binding|extracellular matrix structural constituent|protein binding|extracellular region|collagen type I trimer|extracellular space|cytoplasm|endoplasmic reticulum lumen|Golgi apparatus|blood coagulation|visual perception|sensory perception of sound|response to mechanical stimulus|positive regulation of epithelial to mesenchymal transition|negative regulation of cell-substrate adhesion|protein transport|extracellular matrix structural constituent conferring tensile strength|secretory granule|platelet activation|extracellular matrix organization|collagen fibril organization|positive regulation of cell migration|extracellular matrix|response to corticosteroid|response to estradiol|collagen biosynthetic process|protein localization to nucleus|tooth mineralization|collagen-activated tyrosine kinase receptor signaling pathway|response to drug|response to hydrogen peroxide|identical protein binding|response to peptide hormone|skin development|skin morphogenesis|cellular response to fibroblast growth factor stimulus|tooth eruption|positive regulation of transcription, DNA-templated|metal ion binding|platelet-derived growth factor binding|embryonic skeletal system development|regulation of immune response|leukocyte migration|response to cAMP|response to hyperoxia|face morphogenesis|bone trabecula formation|cartilage development involved in endochondral bone morphogenesis|collagen-containing extracellular matrix|cellular response to amino acid stimulus|cellular response to mechanical stimulus|cellular response to retinoic acid|cellular response to vitamin E|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|cellular response to transforming growth factor beta stimulus|positive regulation of canonical Wnt signaling pathway|cellular response to fluoride" "hsa04151,hsa04510,hsa04512,hsa04611,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05205" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Platelet activation|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Proteoglycans in cancer COL24A1 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.018058861 0.005467994 255631 collagen type XXIV alpha 1 chain "GO:0005201,GO:0005515,GO:0005576,GO:0005581,GO:0005615,GO:0005788,GO:0030020,GO:0030198,GO:0031012,GO:0062023" extracellular matrix structural constituent|protein binding|extracellular region|collagen trimer|extracellular space|endoplasmic reticulum lumen|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|collagen-containing extracellular matrix hsa04974 Protein digestion and absorption COL27A1 686.4340446 774.0679287 598.8001606 0.773575727 -0.370385568 0.149363983 1 4.602337642 3.500680613 85301 collagen type XXVII alpha 1 chain "GO:0003431,GO:0005201,GO:0005576,GO:0005583,GO:0005615,GO:0005788,GO:0030020,GO:0030198,GO:0031012,GO:0046872,GO:0062023" growth plate cartilage chondrocyte development|extracellular matrix structural constituent|extracellular region|fibrillar collagen trimer|extracellular space|endoplasmic reticulum lumen|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|metal ion binding|collagen-containing extracellular matrix hsa04974 Protein digestion and absorption COL4A1 1327.341515 1627.207312 1027.475717 0.631435042 -0.663293769 0.005874819 0.464382349 5.568519627 3.457320273 1282 collagen type IV alpha 1 chain "GO:0001569,GO:0005201,GO:0005515,GO:0005576,GO:0005587,GO:0005604,GO:0005615,GO:0005788,GO:0007420,GO:0007528,GO:0030020,GO:0030198,GO:0030855,GO:0031012,GO:0038063,GO:0048407,GO:0048514,GO:0061304,GO:0061333,GO:0062023,GO:0071230,GO:0071711" branching involved in blood vessel morphogenesis|extracellular matrix structural constituent|protein binding|extracellular region|collagen type IV trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|brain development|neuromuscular junction development|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|epithelial cell differentiation|extracellular matrix|collagen-activated tyrosine kinase receptor signaling pathway|platelet-derived growth factor binding|blood vessel morphogenesis|retinal blood vessel morphogenesis|renal tubule morphogenesis|collagen-containing extracellular matrix|cellular response to amino acid stimulus|basement membrane organization "hsa04151,hsa04510,hsa04512,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer COL4A2 3979.394556 4749.489374 3209.299737 0.675714689 -0.565513877 0.017767734 0.773499658 39.3222958 26.126029 1284 collagen type IV alpha 2 chain "GO:0001525,GO:0005201,GO:0005515,GO:0005576,GO:0005587,GO:0005615,GO:0005788,GO:0006351,GO:0007568,GO:0014823,GO:0016525,GO:0030020,GO:0030198,GO:0031012,GO:0035987,GO:0038063,GO:0062023,GO:0070062,GO:0071560" "angiogenesis|extracellular matrix structural constituent|protein binding|extracellular region|collagen type IV trimer|extracellular space|endoplasmic reticulum lumen|transcription, DNA-templated|aging|response to activity|negative regulation of angiogenesis|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|endodermal cell differentiation|collagen-activated tyrosine kinase receptor signaling pathway|collagen-containing extracellular matrix|extracellular exosome|cellular response to transforming growth factor beta stimulus" "hsa04151,hsa04510,hsa04512,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer COL4A3 4.082397604 6.242483296 1.922311912 0.307940257 -1.699277611 0.406294648 1 0.038693364 0.011715859 1285 collagen type IV alpha 3 chain "GO:0005178,GO:0005198,GO:0005201,GO:0005515,GO:0005576,GO:0005587,GO:0005604,GO:0005615,GO:0005783,GO:0005788,GO:0006919,GO:0007155,GO:0007166,GO:0007605,GO:0008015,GO:0008191,GO:0008285,GO:0009749,GO:0010951,GO:0016525,GO:0030020,GO:0030198,GO:0031012,GO:0032836,GO:0038063,GO:0043231,GO:0062023,GO:0072577,GO:1905563" integrin binding|structural molecule activity|extracellular matrix structural constituent|protein binding|extracellular region|collagen type IV trimer|basement membrane|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell adhesion|cell surface receptor signaling pathway|sensory perception of sound|blood circulation|metalloendopeptidase inhibitor activity|negative regulation of cell population proliferation|response to glucose|negative regulation of endopeptidase activity|negative regulation of angiogenesis|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|glomerular basement membrane development|collagen-activated tyrosine kinase receptor signaling pathway|intracellular membrane-bounded organelle|collagen-containing extracellular matrix|endothelial cell apoptotic process|negative regulation of vascular endothelial cell proliferation "hsa04151,hsa04510,hsa04512,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer COL4A4 26.21855272 32.25283036 20.18427508 0.625814071 -0.676193998 0.387573448 1 0.139194103 0.085651967 1286 collagen type IV alpha 4 chain "GO:0005201,GO:0005576,GO:0005587,GO:0005604,GO:0005615,GO:0005788,GO:0030020,GO:0030198,GO:0031012,GO:0032836,GO:0062023" extracellular matrix structural constituent|extracellular region|collagen type IV trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|glomerular basement membrane development|collagen-containing extracellular matrix "hsa04151,hsa04510,hsa04512,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer COL4A5 1719.253528 1923.725269 1514.781787 0.787421058 -0.3447928 0.146357444 1 14.18034281 10.97905432 1287 collagen type IV alpha 5 chain "GO:0005201,GO:0005576,GO:0005587,GO:0005604,GO:0005615,GO:0005788,GO:0007528,GO:0030020,GO:0030198,GO:0031012,GO:0031594,GO:0038063,GO:0062023" extracellular matrix structural constituent|extracellular region|collagen type IV trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|neuromuscular junction development|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|neuromuscular junction|collagen-activated tyrosine kinase receptor signaling pathway|collagen-containing extracellular matrix "hsa04151,hsa04510,hsa04512,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer COL4A6 1055.57461 1229.769209 881.3800116 0.716703594 -0.480551506 0.049508227 1 7.789048478 5.489024478 1288 collagen type IV alpha 6 chain "GO:0005201,GO:0005515,GO:0005576,GO:0005587,GO:0005615,GO:0005788,GO:0007155,GO:0030020,GO:0030198,GO:0031012,GO:0038063,GO:0062023" extracellular matrix structural constituent|protein binding|extracellular region|collagen type IV trimer|extracellular space|endoplasmic reticulum lumen|cell adhesion|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|collagen-activated tyrosine kinase receptor signaling pathway|collagen-containing extracellular matrix "hsa04151,hsa04510,hsa04512,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer COL5A2 3905.494872 3881.784196 3929.205548 1.01221638 0.017517726 0.942450103 1 29.66686068 29.52678296 1290 collagen type V alpha 2 chain "GO:0001501,GO:0001503,GO:0005201,GO:0005576,GO:0005588,GO:0005615,GO:0005788,GO:0030020,GO:0030198,GO:0030199,GO:0031012,GO:0043588,GO:0046332,GO:0046872,GO:0048592,GO:0062023,GO:0071230,GO:1903225" skeletal system development|ossification|extracellular matrix structural constituent|extracellular region|collagen type V trimer|extracellular space|endoplasmic reticulum lumen|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|collagen fibril organization|extracellular matrix|skin development|SMAD binding|metal ion binding|eye morphogenesis|collagen-containing extracellular matrix|cellular response to amino acid stimulus|negative regulation of endodermal cell differentiation hsa04974 Protein digestion and absorption COL6A1 5530.753261 5810.711535 5250.794988 0.903640622 -0.146178968 0.544577254 1 73.78229716 65.5570039 1291 collagen type VI alpha 1 chain "GO:0001649,GO:0005518,GO:0005576,GO:0005589,GO:0005615,GO:0005765,GO:0005788,GO:0007155,GO:0016020,GO:0030020,GO:0030198,GO:0032991,GO:0035987,GO:0042383,GO:0048407,GO:0062023,GO:0070062,GO:0071230" osteoblast differentiation|collagen binding|extracellular region|collagen type VI trimer|extracellular space|lysosomal membrane|endoplasmic reticulum lumen|cell adhesion|membrane|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|protein-containing complex|endodermal cell differentiation|sarcolemma|platelet-derived growth factor binding|collagen-containing extracellular matrix|extracellular exosome|cellular response to amino acid stimulus "hsa04151,hsa04510,hsa04512,hsa04974,hsa05165" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Protein digestion and absorption|Human papillomavirus infection COL6A2 9982.108031 10081.61052 9882.60554 0.980260596 -0.028762763 0.909221962 1 114.6955925 110.5501798 1292 collagen type VI alpha 2 chain "GO:0005515,GO:0005518,GO:0005576,GO:0005581,GO:0005615,GO:0005788,GO:0007155,GO:0009749,GO:0030020,GO:0030198,GO:0032991,GO:0042383,GO:0062023,GO:0070062,GO:1903561" protein binding|collagen binding|extracellular region|collagen trimer|extracellular space|endoplasmic reticulum lumen|cell adhesion|response to glucose|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|protein-containing complex|sarcolemma|collagen-containing extracellular matrix|extracellular exosome|extracellular vesicle "hsa04151,hsa04510,hsa04512,hsa04974,hsa05165" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Protein digestion and absorption|Human papillomavirus infection COL6A3 6.926236509 5.202069413 8.650403604 1.662877389 0.733681797 0.660649523 1 0.024568574 0.040170881 1293 collagen type VI alpha 3 chain "GO:0004867,GO:0005576,GO:0005589,GO:0005615,GO:0005788,GO:0007155,GO:0007517,GO:0010951,GO:0030020,GO:0030198,GO:0031012,GO:0042383,GO:0062023,GO:0070062,GO:1903561" serine-type endopeptidase inhibitor activity|extracellular region|collagen type VI trimer|extracellular space|endoplasmic reticulum lumen|cell adhesion|muscle organ development|negative regulation of endopeptidase activity|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|sarcolemma|collagen-containing extracellular matrix|extracellular exosome|extracellular vesicle "hsa04151,hsa04510,hsa04512,hsa04974,hsa05165" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Protein digestion and absorption|Human papillomavirus infection COL7A1 2661.337508 3138.928684 2183.746332 0.695697976 -0.523466972 0.027030596 0.873268385 17.93563755 12.26898788 1294 collagen type VII alpha 1 chain "GO:0000139,GO:0004867,GO:0005515,GO:0005576,GO:0005590,GO:0005604,GO:0005615,GO:0005788,GO:0006888,GO:0007155,GO:0008544,GO:0010951,GO:0030020,GO:0030134,GO:0030198,GO:0033116,GO:0035987,GO:0048208,GO:0062023" Golgi membrane|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|collagen type VII trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|endoplasmic reticulum to Golgi vesicle-mediated transport|cell adhesion|epidermis development|negative regulation of endopeptidase activity|extracellular matrix structural constituent conferring tensile strength|COPII-coated ER to Golgi transport vesicle|extracellular matrix organization|endoplasmic reticulum-Golgi intermediate compartment membrane|endodermal cell differentiation|COPII vesicle coating|collagen-containing extracellular matrix hsa04974 Protein digestion and absorption COL8A1 1171.319676 1215.203415 1127.435936 0.927775484 -0.108152371 0.657812032 1 11.62868438 10.60827219 1295 collagen type VIII alpha 1 chain "GO:0001525,GO:0005201,GO:0005515,GO:0005576,GO:0005591,GO:0005615,GO:0005788,GO:0007155,GO:0010811,GO:0030020,GO:0030198,GO:0031012,GO:0035987,GO:0048593,GO:0050673,GO:0062023" angiogenesis|extracellular matrix structural constituent|protein binding|extracellular region|collagen type VIII trimer|extracellular space|endoplasmic reticulum lumen|cell adhesion|positive regulation of cell-substrate adhesion|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|endodermal cell differentiation|camera-type eye morphogenesis|epithelial cell proliferation|collagen-containing extracellular matrix hsa04974 Protein digestion and absorption COL8A2 12.29185219 7.282897178 17.30080721 2.375539127 1.248254969 0.245646158 1 0.072016831 0.168216028 1296 collagen type VIII alpha 2 chain "GO:0001525,GO:0005201,GO:0005576,GO:0005581,GO:0005604,GO:0005615,GO:0005788,GO:0030020,GO:0030198,GO:0030674,GO:0031012,GO:0048593,GO:0050673,GO:0062023,GO:0098609" angiogenesis|extracellular matrix structural constituent|extracellular region|collagen trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|protein-macromolecule adaptor activity|extracellular matrix|camera-type eye morphogenesis|epithelial cell proliferation|collagen-containing extracellular matrix|cell-cell adhesion hsa04974 Protein digestion and absorption COL9A2 44.19808272 37.45489978 50.94126567 1.36006947 0.443680343 0.493526875 1 0.506435055 0.677260941 1298 collagen type IX alpha 2 chain "GO:0001501,GO:0005201,GO:0005515,GO:0005576,GO:0005594,GO:0005615,GO:0005788,GO:0030020,GO:0030198,GO:0031012,GO:0062023" skeletal system development|extracellular matrix structural constituent|protein binding|extracellular region|collagen type IX trimer|extracellular space|endoplasmic reticulum lumen|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|collagen-containing extracellular matrix "hsa04151,hsa04510,hsa04512,hsa04974,hsa05165" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Protein digestion and absorption|Human papillomavirus infection COL9A3 174.3051527 160.2237379 188.3865674 1.175771891 0.233608194 0.549270973 1 3.183487124 3.680419726 1299 collagen type IX alpha 3 chain "GO:0005201,GO:0005576,GO:0005594,GO:0005604,GO:0005615,GO:0005788,GO:0008584,GO:0008585,GO:0030020,GO:0030198,GO:0031012,GO:0062023" extracellular matrix structural constituent|extracellular region|collagen type IX trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|male gonad development|female gonad development|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|extracellular matrix|collagen-containing extracellular matrix "hsa04151,hsa04510,hsa04512,hsa04974,hsa05165" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Protein digestion and absorption|Human papillomavirus infection COLEC10 4.523346619 5.202069413 3.844623824 0.739056617 -0.436243205 0.933440272 1 0.078358703 0.056942447 10584 collectin subfamily member 10 "GO:0001867,GO:0005537,GO:0005576,GO:0005581,GO:0005615,GO:0005737,GO:0005794,GO:0006956,GO:0042056,GO:0050918,GO:1904888" "complement activation, lectin pathway|mannose binding|extracellular region|collagen trimer|extracellular space|cytoplasm|Golgi apparatus|complement activation|chemoattractant activity|positive chemotaxis|cranial skeletal system development" COLEC11 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.028874143 0.078684512 78989 collectin subfamily member 11 "GO:0001867,GO:0003677,GO:0005509,GO:0005515,GO:0005537,GO:0005576,GO:0005581,GO:0005615,GO:0006898,GO:0006956,GO:0007275,GO:0019730,GO:0032502,GO:0042806,GO:0070492,GO:0097194,GO:0120153" "complement activation, lectin pathway|DNA binding|calcium ion binding|protein binding|mannose binding|extracellular region|collagen trimer|extracellular space|receptor-mediated endocytosis|complement activation|multicellular organism development|antimicrobial humoral response|developmental process|fucose binding|oligosaccharide binding|execution phase of apoptosis|calcium-dependent carbohydrate binding" hsa04145 Phagosome COLGALT1 2575.975109 2790.390033 2361.560184 0.846319029 -0.240726489 0.308645253 1 37.85408936 31.50054644 79709 collagen beta(1-O)galactosyltransferase 1 "GO:0005788,GO:0016020,GO:0018215,GO:0050211,GO:1904028" endoplasmic reticulum lumen|membrane|protein phosphopantetheinylation|procollagen galactosyltransferase activity|positive regulation of collagen fibril organization "hsa00310,hsa00514" Lysine degradation|Other types of O-glycan biosynthesis COLGALT2 100.3609251 98.83931885 101.8825313 1.030789493 0.043749736 0.948571826 1 0.908364524 0.920664348 23127 collagen beta(1-O)galactosyltransferase 2 "GO:0005515,GO:0005788,GO:0018215,GO:0050211" protein binding|endoplasmic reticulum lumen|protein phosphopantetheinylation|procollagen galactosyltransferase activity "hsa00310,hsa00514" Lysine degradation|Other types of O-glycan biosynthesis COLQ 4.642233509 8.323311061 0.961155956 0.115477596 -3.11431511 0.11677594 1 0.133754837 0.015187224 8292 collagen like tail subunit of asymmetric acetylcholinesterase "GO:0001507,GO:0005201,GO:0005515,GO:0005581,GO:0005604,GO:0005615,GO:0005886,GO:0008201,GO:0030054,GO:0030198,GO:0031012,GO:0043083,GO:0062023" acetylcholine catabolic process in synaptic cleft|extracellular matrix structural constituent|protein binding|collagen trimer|basement membrane|extracellular space|plasma membrane|heparin binding|cell junction|extracellular matrix organization|extracellular matrix|synaptic cleft|collagen-containing extracellular matrix COMMD1 202.0597885 157.1024963 247.0170807 1.572330717 0.6529047 0.071501173 1 2.779930863 4.297828414 150684 copper metabolism domain containing 1 "GO:0005507,GO:0005515,GO:0005546,GO:0005547,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0006289,GO:0006893,GO:0010008,GO:0015031,GO:0016567,GO:0019871,GO:0031398,GO:0031462,GO:0032088,GO:0032434,GO:0042802,GO:0042803,GO:0043325,GO:0043687,GO:0048227,GO:0055037,GO:0055070,GO:0070300,GO:0080025,GO:1902306,GO:2000009" "copper ion binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|nucleoplasm|cytoplasm|endosome|early endosome|cytosol|nucleotide-excision repair|Golgi to plasma membrane transport|endosome membrane|protein transport|protein ubiquitination|sodium channel inhibitor activity|positive regulation of protein ubiquitination|Cul2-RING ubiquitin ligase complex|negative regulation of NF-kappaB transcription factor activity|regulation of proteasomal ubiquitin-dependent protein catabolic process|identical protein binding|protein homodimerization activity|phosphatidylinositol-3,4-bisphosphate binding|post-translational protein modification|plasma membrane to endosome transport|recycling endosome|copper ion homeostasis|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|negative regulation of sodium ion transmembrane transport|negative regulation of protein localization to cell surface" COMMD10 330.3734942 258.0226429 402.7243456 1.560810094 0.642295013 0.035638484 0.95186772 8.715312801 13.37532128 51397 COMM domain containing 10 "GO:0005515,GO:0005654,GO:0005737" protein binding|nucleoplasm|cytoplasm COMMD2 581.72338 636.7332962 526.7134639 0.827212064 -0.27367087 0.301564583 1 9.19904866 7.482228277 51122 COMM domain containing 2 "GO:0005515,GO:0005737" protein binding|cytoplasm COMMD3 44.27231023 52.02069413 36.52392633 0.702103787 -0.510243786 0.42528933 1 2.998108894 2.069759557 23412 COMM domain containing 3 "GO:0005515,GO:0005576,GO:0005634,GO:0006814,GO:0043312,GO:1904813" protein binding|extracellular region|nucleus|sodium ion transport|neutrophil degranulation|ficolin-1-rich granule lumen COMMD4 840.5957799 733.4917873 947.6997726 1.292038696 0.369649279 0.139573911 1 36.89454155 46.87149628 54939 COMM domain containing 4 "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0043231" protein binding|nucleus|cytoplasm|cytosol|plasma membrane|intracellular membrane-bounded organelle COMMD5 371.5094716 341.2557535 401.7631896 1.177308179 0.235492018 0.427816187 1 10.53946317 12.20056183 28991 COMM domain containing 5 "GO:0005515,GO:0005634,GO:0005654,GO:0005829" protein binding|nucleus|nucleoplasm|cytosol COMMD6 811.4189175 787.5933092 835.2445258 1.060502313 0.084747767 0.739576405 1 20.9637942 21.86012727 170622 COMM domain containing 6 "GO:0005515,GO:0005634,GO:0005737,GO:0032088,GO:0051059" protein binding|nucleus|cytoplasm|negative regulation of NF-kappaB transcription factor activity|NF-kappaB binding COMMD7 1186.024479 1197.516379 1174.532578 0.98080711 -0.027958658 0.911696933 1 35.07642602 33.82751692 149951 COMM domain containing 7 "GO:0005515,GO:0031410,GO:0032088,GO:0033209,GO:0045892,GO:0051059" "protein binding|cytoplasmic vesicle|negative regulation of NF-kappaB transcription factor activity|tumor necrosis factor-mediated signaling pathway|negative regulation of transcription, DNA-templated|NF-kappaB binding" COMMD8 279.5114865 260.1034707 298.9195023 1.14923304 0.200671376 0.53952248 1 4.863785627 5.496088369 54951 COMM domain containing 8 "GO:0005515,GO:0005654,GO:0005829" protein binding|nucleoplasm|cytosol COMMD9 682.2534962 613.8441908 750.6628016 1.222888174 0.290292484 0.259580926 1 11.00058303 13.22737381 29099 COMM domain containing 9 "GO:0005515,GO:0005576,GO:0005654,GO:0005794,GO:0005829,GO:0006814,GO:0034774,GO:0042632,GO:0043312,GO:1904813" protein binding|extracellular region|nucleoplasm|Golgi apparatus|cytosol|sodium ion transport|secretory granule lumen|cholesterol homeostasis|neutrophil degranulation|ficolin-1-rich granule lumen COMT 1042.436073 1137.172374 947.6997726 0.833382691 -0.262948959 0.283249465 1 21.26447076 17.42489753 1312 catechol-O-methyltransferase "GO:0000287,GO:0005515,GO:0005829,GO:0005886,GO:0008168,GO:0008171,GO:0016020,GO:0016021,GO:0016206,GO:0030424,GO:0030425,GO:0032259,GO:0032502,GO:0042135,GO:0042417,GO:0042424,GO:0043231,GO:0070062,GO:0102084,GO:0102938" magnesium ion binding|protein binding|cytosol|plasma membrane|methyltransferase activity|O-methyltransferase activity|membrane|integral component of membrane|catechol O-methyltransferase activity|axon|dendrite|methylation|developmental process|neurotransmitter catabolic process|dopamine metabolic process|catecholamine catabolic process|intracellular membrane-bounded organelle|extracellular exosome|L-dopa O-methyltransferase activity|orcinol O-methyltransferase activity "hsa00140,hsa00350,hsa04728" Steroid hormone biosynthesis|Tyrosine metabolism|Dopaminergic synapse COMTD1 229.0658901 222.6485709 235.4832092 1.057645276 0.080855843 0.826497437 1 9.001776528 9.361370628 118881 catechol-O-methyltransferase domain containing 1 "GO:0005515,GO:0008171,GO:0008757,GO:0016021,GO:0032259" protein binding|O-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|integral component of membrane|methylation COP1 717.6571363 710.6026818 724.7115908 1.019854849 0.028363835 0.917206152 1 4.081752136 4.093135977 64326 COP1 E3 ubiquitin ligase "GO:0000139,GO:0004842,GO:0005515,GO:0005654,GO:0005829,GO:0010212,GO:0016567,GO:0016607,GO:0031464,GO:0032436,GO:0043161,GO:0043687,GO:0046872,GO:0061630" Golgi membrane|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytosol|response to ionizing radiation|protein ubiquitination|nuclear speck|Cul4A-RING E3 ubiquitin ligase complex|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|metal ion binding|ubiquitin protein ligase activity "hsa04115,hsa04120" p53 signaling pathway|Ubiquitin mediated proteolysis COPA 8811.072133 9454.240952 8167.903314 0.863940675 -0.210995845 0.396006601 1 94.39765452 80.18927812 1314 COPI coat complex subunit alpha "GO:0000139,GO:0005179,GO:0005198,GO:0005515,GO:0005615,GO:0005737,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0007165,GO:0016020,GO:0030126,GO:0030133,GO:0030157,GO:0030426,GO:0070062" "Golgi membrane|hormone activity|structural molecule activity|protein binding|extracellular space|cytoplasm|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|signal transduction|membrane|COPI vesicle coat|transport vesicle|pancreatic juice secretion|growth cone|extracellular exosome" COPB1 7525.523123 6678.416713 8372.629533 1.253684802 0.326174675 0.184367371 1 103.78999 127.9425521 1315 COPI coat complex subunit beta 1 "GO:0000139,GO:0005198,GO:0005515,GO:0005789,GO:0005793,GO:0005794,GO:0005798,GO:0005829,GO:0005886,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0016020,GO:0016032,GO:0030126,GO:0030133,GO:0030667,GO:0043231,GO:0043312,GO:0070821,GO:0101003" "Golgi membrane|structural molecule activity|protein binding|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|Golgi-associated vesicle|cytosol|plasma membrane|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|membrane|viral process|COPI vesicle coat|transport vesicle|secretory granule membrane|intracellular membrane-bounded organelle|neutrophil degranulation|tertiary granule membrane|ficolin-1-rich granule membrane" COPB2 4963.72205 4790.065516 5137.378585 1.072506956 0.100987005 0.674288551 1 50.0463964 52.77692801 9276 COPI coat complex subunit beta 2 "GO:0000139,GO:0005198,GO:0005515,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0030126,GO:0030133,GO:1901998" "Golgi membrane|structural molecule activity|protein binding|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|COPI vesicle coat|transport vesicle|toxin transport" COPE 1313.125392 1127.808649 1498.442135 1.328631534 0.409941061 0.088349755 1 50.1575623 65.52577343 11316 COPI coat complex subunit epsilon "GO:0000139,GO:0005198,GO:0005515,GO:0005654,GO:0005789,GO:0005794,GO:0005829,GO:0006888,GO:0006890,GO:0006891,GO:0015031,GO:0030126,GO:0030133" "Golgi membrane|structural molecule activity|protein binding|nucleoplasm|endoplasmic reticulum membrane|Golgi apparatus|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|protein transport|COPI vesicle coat|transport vesicle" COPG1 4167.610588 4278.181885 4057.03929 0.948309211 -0.076570545 0.748753561 1 70.14399516 65.4051048 22820 COPI coat complex subunit gamma 1 "GO:0000139,GO:0005198,GO:0005515,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0009306,GO:0030126,GO:0030133,GO:0051683,GO:0072384" "Golgi membrane|structural molecule activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|protein secretion|COPI vesicle coat|transport vesicle|establishment of Golgi localization|organelle transport along microtubule" COPG2 1159.157386 1085.15168 1233.163092 1.13639698 0.184466903 0.448396101 1 14.40252443 16.09310593 26958 COPI coat complex subunit gamma 2 "GO:0000139,GO:0005198,GO:0005783,GO:0005789,GO:0005793,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0009306,GO:0030126,GO:0030133,GO:0030426,GO:0072384" "Golgi membrane|structural molecule activity|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|protein secretion|COPI vesicle coat|transport vesicle|growth cone|organelle transport along microtubule" COPRS 683.670078 676.2690237 691.0711324 1.0218879 0.031236943 0.909162284 1 33.63582001 33.79686797 55352 coordinator of PRMT5 and differentiation stimulator "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0007517,GO:0042393,GO:0043985" protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|muscle organ development|histone binding|histone H4-R3 methylation COPS2 1567.398375 1507.559716 1627.237033 1.079384794 0.110209268 0.645084206 1 12.1957998 12.9436798 9318 COP9 signalosome subunit 2 "GO:0000122,GO:0000338,GO:0000715,GO:0001833,GO:0003714,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006283,GO:0006366,GO:0006468,GO:0007165,GO:0008180,GO:0030182,GO:0035914,GO:0043687,GO:0045892,GO:1903507" "negative regulation of transcription by RNA polymerase II|protein deneddylation|nucleotide-excision repair, DNA damage recognition|inner cell mass cell proliferation|transcription corepressor activity|protein binding|nucleoplasm|cytoplasm|cytosol|transcription-coupled nucleotide-excision repair|transcription by RNA polymerase II|protein phosphorylation|signal transduction|COP9 signalosome|neuron differentiation|skeletal muscle cell differentiation|post-translational protein modification|negative regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription" COPS3 1640.712955 1640.732693 1640.693217 0.99997594 -3.47E-05 1 1 45.01947984 44.26507477 8533 COP9 signalosome subunit 3 "GO:0000338,GO:0000715,GO:0001701,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006283,GO:0006511,GO:0007165,GO:0008180,GO:0009416,GO:0043687" "protein deneddylation|nucleotide-excision repair, DNA damage recognition|in utero embryonic development|protein binding|nucleoplasm|cytoplasm|cytosol|transcription-coupled nucleotide-excision repair|ubiquitin-dependent protein catabolic process|signal transduction|COP9 signalosome|response to light stimulus|post-translational protein modification" COPS4 702.2937323 673.1477821 731.4396825 1.086595993 0.119815632 0.643287355 1 19.96923843 21.33539954 51138 COP9 signalosome subunit 4 "GO:0000338,GO:0000715,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006283,GO:0008021,GO:0008180,GO:0016607,GO:0019784,GO:0030054,GO:0043687" "protein deneddylation|nucleotide-excision repair, DNA damage recognition|protein binding|nucleus|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|synaptic vesicle|COP9 signalosome|nuclear speck|NEDD8-specific protease activity|cell junction|post-translational protein modification" COPS5 1433.917198 1409.760811 1458.073585 1.034270192 0.048613124 0.841592554 1 58.05273414 59.0374874 10987 COP9 signalosome subunit 5 "GO:0000338,GO:0000715,GO:0000785,GO:0003713,GO:0003743,GO:0004222,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005852,GO:0006283,GO:0006412,GO:0006413,GO:0008021,GO:0008180,GO:0008237,GO:0016579,GO:0018215,GO:0019784,GO:0019899,GO:0035718,GO:0043066,GO:0043687,GO:0045944,GO:0046328,GO:0046872,GO:0048471,GO:0051091,GO:0051726,GO:0070122,GO:1903894,GO:1990182" "protein deneddylation|nucleotide-excision repair, DNA damage recognition|chromatin|transcription coactivator activity|translation initiation factor activity|metalloendopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|eukaryotic translation initiation factor 3 complex|transcription-coupled nucleotide-excision repair|translation|translational initiation|synaptic vesicle|COP9 signalosome|metallopeptidase activity|protein deubiquitination|protein phosphopantetheinylation|NEDD8-specific protease activity|enzyme binding|macrophage migration inhibitory factor binding|negative regulation of apoptotic process|post-translational protein modification|positive regulation of transcription by RNA polymerase II|regulation of JNK cascade|metal ion binding|perinuclear region of cytoplasm|positive regulation of DNA-binding transcription factor activity|regulation of cell cycle|isopeptidase activity|regulation of IRE1-mediated unfolded protein response|exosomal secretion" COPS6 3068.785802 2745.652236 3391.919369 1.235378364 0.30495297 0.197910256 1 104.3663914 126.7744798 10980 COP9 signalosome subunit 6 "GO:0000338,GO:0000715,GO:0005515,GO:0005654,GO:0005829,GO:0006283,GO:0008180,GO:0008237,GO:0016032,GO:0043687,GO:0048471,GO:0070122" "protein deneddylation|nucleotide-excision repair, DNA damage recognition|protein binding|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|COP9 signalosome|metallopeptidase activity|viral process|post-translational protein modification|perinuclear region of cytoplasm|isopeptidase activity" COPS7A 1169.893033 1177.748515 1162.037551 0.986660171 -0.019374823 0.940091592 1 29.46754507 28.58793145 50813 COP9 signalosome subunit 7A "GO:0000338,GO:0000715,GO:0005515,GO:0005654,GO:0005829,GO:0006283,GO:0008180,GO:0010387,GO:0016032,GO:0043687" "protein deneddylation|nucleotide-excision repair, DNA damage recognition|protein binding|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|COP9 signalosome|COP9 signalosome assembly|viral process|post-translational protein modification" COPS7B 812.3951647 750.1384094 874.65192 1.165987382 0.221552176 0.378776684 1 13.02326227 14.93085974 64708 COP9 signalosome subunit 7B "GO:0000338,GO:0000715,GO:0005515,GO:0005654,GO:0005829,GO:0006283,GO:0008180,GO:0010387,GO:0016032,GO:0043687" "protein deneddylation|nucleotide-excision repair, DNA damage recognition|protein binding|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|COP9 signalosome|COP9 signalosome assembly|viral process|post-translational protein modification" COPS8 1520.779124 1217.284243 1824.274004 1.498642585 0.583656353 0.014553325 0.708244576 18.54531052 27.32771737 10920 COP9 signalosome subunit 8 "GO:0000338,GO:0000715,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006283,GO:0006468,GO:0007250,GO:0008180,GO:0008285,GO:0010387,GO:0043687,GO:0048471,GO:0070062" "protein deneddylation|nucleotide-excision repair, DNA damage recognition|protein binding|nucleus|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|protein phosphorylation|activation of NF-kappaB-inducing kinase activity|COP9 signalosome|negative regulation of cell population proliferation|COP9 signalosome assembly|post-translational protein modification|perinuclear region of cytoplasm|extracellular exosome" COPS9 213.0583618 193.5169822 232.5997414 1.201960359 0.265389316 0.4592037 1 10.31732834 12.19350541 150678 COP9 signalosome subunit 9 "GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008180,GO:0008284,GO:0034644,GO:2000435" chromatin|protein binding|nucleus|nucleoplasm|cytoplasm|COP9 signalosome|positive regulation of cell population proliferation|cellular response to UV|negative regulation of protein neddylation COPZ1 3932.938121 3756.93453 4108.941712 1.09369532 0.12921089 0.587639271 1 101.5707654 109.2285724 22818 COPI coat complex subunit zeta 1 "GO:0000139,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0030126,GO:0030133" "Golgi membrane|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|COPI vesicle coat|transport vesicle" COPZ2 256.4884029 248.658918 264.3178879 1.062973691 0.088105891 0.801023536 1 14.51911317 15.17517768 51226 COPI coat complex subunit zeta 2 "GO:0000139,GO:0005789,GO:0005801,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0030126,GO:0030133,GO:0033116" "Golgi membrane|endoplasmic reticulum membrane|cis-Golgi network|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|COPI vesicle coat|transport vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane" COQ10A 337.7054668 349.5790646 325.8318691 0.932069171 -0.10149107 0.745664354 1 11.11823133 10.18955055 93058 coenzyme Q10A "GO:0005739,GO:0005743,GO:0006744,GO:0045333,GO:0048039" mitochondrion|mitochondrial inner membrane|ubiquinone biosynthetic process|cellular respiration|ubiquinone binding COQ10B 868.3347101 868.745592 867.9238283 0.99905408 -0.00136532 1 1 21.49436975 21.11469886 80219 coenzyme Q10B "GO:0005739,GO:0005743,GO:0006744,GO:0045333,GO:0048039" mitochondrion|mitochondrial inner membrane|ubiquinone biosynthetic process|cellular respiration|ubiquinone binding COQ2 426.9439013 421.3676225 432.5201802 1.026467524 0.037687984 0.902933728 1 14.74597742 14.88298201 27235 "coenzyme Q2, polyprenyltransferase" "GO:0002083,GO:0004659,GO:0005743,GO:0006071,GO:0006744,GO:0008299,GO:0016765,GO:0031305,GO:0047293" "4-hydroxybenzoate decaprenyltransferase activity|prenyltransferase activity|mitochondrial inner membrane|glycerol metabolic process|ubiquinone biosynthetic process|isoprenoid biosynthetic process|transferase activity, transferring alkyl or aryl (other than methyl) groups|integral component of mitochondrial inner membrane|4-hydroxybenzoate nonaprenyltransferase activity" hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis COQ3 189.832103 189.3553266 190.3088793 1.005035785 0.00724687 1 1 6.540806319 6.463741701 51805 "coenzyme Q3, methyltransferase" "GO:0004395,GO:0005515,GO:0005739,GO:0005759,GO:0006071,GO:0006744,GO:0008171,GO:0008425,GO:0008689,GO:0010795,GO:0031314,GO:0032259,GO:0044595,GO:0044596" "hexaprenyldihydroxybenzoate methyltransferase activity|protein binding|mitochondrion|mitochondrial matrix|glycerol metabolic process|ubiquinone biosynthetic process|O-methyltransferase activity|2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|regulation of ubiquinone biosynthetic process|extrinsic component of mitochondrial inner membrane|methylation|decaprenyldihydroxybenzoate methyltransferase activity|3-demethylubiquinol-10 3-O-methyltransferase activity" hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis COQ4 494.1304691 456.7416945 531.5192437 1.16371956 0.218743431 0.426971717 1 13.65572257 15.62550987 51117 coenzyme Q4 "GO:0005515,GO:0005739,GO:0006744,GO:0031314,GO:0032991" protein binding|mitochondrion|ubiquinone biosynthetic process|extrinsic component of mitochondrial inner membrane|protein-containing complex COQ5 404.8920346 384.9531366 424.8309325 1.1035913 0.142205989 0.626912463 1 10.80138874 11.72084826 84274 "coenzyme Q5, methyltransferase" "GO:0005515,GO:0005743,GO:0005759,GO:0006744,GO:0008168,GO:0031314,GO:0032259,GO:0032991,GO:0043333,GO:0043430" "protein binding|mitochondrial inner membrane|mitochondrial matrix|ubiquinone biosynthetic process|methyltransferase activity|extrinsic component of mitochondrial inner membrane|methylation|protein-containing complex|2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity|2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity" hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis COQ6 286.7201562 260.1034707 313.3368417 1.204662286 0.26862876 0.40474954 1 5.154565236 6.105602596 51004 "coenzyme Q6, monooxygenase" "GO:0005515,GO:0005739,GO:0005794,GO:0006744,GO:0016491,GO:0016709,GO:0016712,GO:0031314,GO:0042995,GO:0055114,GO:0071949" "protein binding|mitochondrion|Golgi apparatus|ubiquinone biosynthetic process|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|extrinsic component of mitochondrial inner membrane|cell projection|oxidation-reduction process|FAD binding" hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis COQ7 241.4715987 245.5376763 237.4055211 0.966880214 -0.048590928 0.898383164 1 4.033208527 3.834374507 10229 "coenzyme Q7, hydroxylase" "GO:0005515,GO:0005634,GO:0005743,GO:0006744,GO:0008340,GO:0008682,GO:0010468,GO:0016709,GO:0031314,GO:0046872,GO:0055114,GO:2000377" "protein binding|nucleus|mitochondrial inner membrane|ubiquinone biosynthetic process|determination of adult lifespan|2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity|regulation of gene expression|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|extrinsic component of mitochondrial inner membrane|metal ion binding|oxidation-reduction process|regulation of reactive oxygen species metabolic process" hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis COQ8A 262.7604543 287.1542316 238.3666771 0.830099824 -0.268643256 0.417823756 1 4.332737793 3.536420567 56997 coenzyme Q8A "GO:0004672,GO:0005515,GO:0005524,GO:0005739,GO:0006468,GO:0006744,GO:0016021,GO:0016301,GO:0016310,GO:0031314,GO:0043531" protein kinase activity|protein binding|ATP binding|mitochondrion|protein phosphorylation|ubiquinone biosynthetic process|integral component of membrane|kinase activity|phosphorylation|extrinsic component of mitochondrial inner membrane|ADP binding COQ8B 183.3021561 194.5573961 172.0469161 0.884299027 -0.177393793 0.645803221 1 4.136721373 3.59688536 79934 coenzyme Q8B "GO:0004672,GO:0005524,GO:0005739,GO:0005829,GO:0005886,GO:0006468,GO:0006744,GO:0008289,GO:0016021,GO:0016301,GO:0016887,GO:0021692,GO:0031314" protein kinase activity|ATP binding|mitochondrion|cytosol|plasma membrane|protein phosphorylation|ubiquinone biosynthetic process|lipid binding|integral component of membrane|kinase activity|ATPase activity|cerebellar Purkinje cell layer morphogenesis|extrinsic component of mitochondrial inner membrane COQ9 703.8738604 727.249304 680.4984168 0.93571546 -0.095858205 0.712019154 1 23.81101762 21.90750603 57017 coenzyme Q9 "GO:0005515,GO:0005739,GO:0005743,GO:0006120,GO:0006744,GO:0008289,GO:0042803" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial electron transport, NADH to ubiquinone|ubiquinone biosynthetic process|lipid binding|protein homodimerization activity" CORIN 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.010520079 0.028668116 10699 "corin, serine peptidase" "GO:0003050,GO:0004175,GO:0004252,GO:0005515,GO:0005576,GO:0005886,GO:0007565,GO:0008217,GO:0009986,GO:0015629,GO:0016021,GO:0016486,GO:0016604,GO:0035813,GO:1903779" regulation of systemic arterial blood pressure by atrial natriuretic peptide|endopeptidase activity|serine-type endopeptidase activity|protein binding|extracellular region|plasma membrane|female pregnancy|regulation of blood pressure|cell surface|actin cytoskeleton|integral component of membrane|peptide hormone processing|nuclear body|regulation of renal sodium excretion|regulation of cardiac conduction CORO1A 313.9797371 193.5169822 434.4424921 2.244983811 1.166705041 0.000199915 0.059431366 5.075010157 11.20266393 11151 coronin 1A "GO:0001771,GO:0001772,GO:0001845,GO:0001891,GO:0003723,GO:0003779,GO:0003785,GO:0005515,GO:0005634,GO:0005737,GO:0005769,GO:0005829,GO:0005884,GO:0005886,GO:0005911,GO:0006816,GO:0006909,GO:0007015,GO:0008022,GO:0008092,GO:0008360,GO:0016020,GO:0016477,GO:0030027,GO:0030036,GO:0030335,GO:0030424,GO:0030595,GO:0030670,GO:0030864,GO:0031339,GO:0031589,GO:0032036,GO:0032796,GO:0032956,GO:0032991,GO:0038180,GO:0042102,GO:0042803,GO:0043029,GO:0043320,GO:0043524,GO:0043548,GO:0045087,GO:0045335,GO:0048873,GO:0050918,GO:0051015,GO:0051126,GO:0051279,GO:0061502,GO:0070062,GO:0071353,GO:0098978" immunological synapse formation|immunological synapse|phagolysosome assembly|phagocytic cup|RNA binding|actin binding|actin monomer binding|protein binding|nucleus|cytoplasm|early endosome|cytosol|actin filament|plasma membrane|cell-cell junction|calcium ion transport|phagocytosis|actin filament organization|protein C-terminus binding|cytoskeletal protein binding|regulation of cell shape|membrane|cell migration|lamellipodium|actin cytoskeleton organization|positive regulation of cell migration|axon|leukocyte chemotaxis|phagocytic vesicle membrane|cortical actin cytoskeleton|negative regulation of vesicle fusion|cell-substrate adhesion|myosin heavy chain binding|uropod organization|regulation of actin cytoskeleton organization|protein-containing complex|nerve growth factor signaling pathway|positive regulation of T cell proliferation|protein homodimerization activity|T cell homeostasis|natural killer cell degranulation|negative regulation of neuron apoptotic process|phosphatidylinositol 3-kinase binding|innate immune response|phagocytic vesicle|homeostasis of number of cells within a tissue|positive chemotaxis|actin filament binding|negative regulation of actin nucleation|regulation of release of sequestered calcium ion into cytosol|early endosome to recycling endosome transport|extracellular exosome|cellular response to interleukin-4|glutamatergic synapse "hsa04145,hsa05152" Phagosome|Tuberculosis CORO1B 2055.399603 2068.342799 2042.456406 0.987484477 -0.018170026 0.940937859 1 24.70538355 23.98794567 57175 coronin 1B "GO:0001725,GO:0005515,GO:0005737,GO:0005829,GO:0005884,GO:0005886,GO:0005925,GO:0007015,GO:0016477,GO:0030027,GO:0030036,GO:0031252,GO:0031529,GO:0034315,GO:0034316,GO:0035767,GO:0036120,GO:0042060,GO:0042802,GO:0045296,GO:0048471,GO:0051015,GO:0051017,GO:0070062,GO:0071672,GO:0071933,GO:0071944,GO:0090135,GO:1902463,GO:2000394" stress fiber|protein binding|cytoplasm|cytosol|actin filament|plasma membrane|focal adhesion|actin filament organization|cell migration|lamellipodium|actin cytoskeleton organization|cell leading edge|ruffle organization|regulation of Arp2/3 complex-mediated actin nucleation|negative regulation of Arp2/3 complex-mediated actin nucleation|endothelial cell chemotaxis|cellular response to platelet-derived growth factor stimulus|wound healing|identical protein binding|cadherin binding|perinuclear region of cytoplasm|actin filament binding|actin filament bundle assembly|extracellular exosome|negative regulation of smooth muscle cell chemotaxis|Arp2/3 complex binding|cell periphery|actin filament branching|protein localization to cell leading edge|positive regulation of lamellipodium morphogenesis CORO1C 10387.49059 9646.71752 11128.26366 1.153580338 0.20611848 0.41381252 1 100.3171442 113.7874026 23603 coronin 1C "GO:0001755,GO:0001932,GO:0001933,GO:0005515,GO:0005925,GO:0005938,GO:0006909,GO:0007015,GO:0007165,GO:0010008,GO:0010632,GO:0010633,GO:0010762,GO:0015629,GO:0016197,GO:0016328,GO:0016477,GO:0016600,GO:0030017,GO:0030027,GO:0031267,GO:0031982,GO:0032587,GO:0042383,GO:0044387,GO:0045184,GO:0045202,GO:0051015,GO:0051893,GO:0051895,GO:0090148,GO:0090630,GO:0097750,GO:0140285,GO:1900024,GO:1900025,GO:1900027,GO:2000394" neural crest cell migration|regulation of protein phosphorylation|negative regulation of protein phosphorylation|protein binding|focal adhesion|cell cortex|phagocytosis|actin filament organization|signal transduction|endosome membrane|regulation of epithelial cell migration|negative regulation of epithelial cell migration|regulation of fibroblast migration|actin cytoskeleton|endosomal transport|lateral plasma membrane|cell migration|flotillin complex|sarcomere|lamellipodium|small GTPase binding|vesicle|ruffle membrane|sarcolemma|negative regulation of protein kinase activity by regulation of protein phosphorylation|establishment of protein localization|synapse|actin filament binding|regulation of focal adhesion assembly|negative regulation of focal adhesion assembly|membrane fission|activation of GTPase activity|endosome membrane tubulation|endosome fission|regulation of substrate adhesion-dependent cell spreading|negative regulation of substrate adhesion-dependent cell spreading|regulation of ruffle assembly|positive regulation of lamellipodium morphogenesis CORO2A 1044.814425 1098.67706 990.9517906 0.901950015 -0.148880612 0.544822958 1 9.510847593 8.434762742 7464 coronin 2A "GO:0005515,GO:0017053,GO:0035556,GO:0051015" protein binding|transcription repressor complex|intracellular signal transduction|actin filament binding CORO2B 552.6716636 479.6307999 625.7125274 1.304571198 0.383575683 0.151434231 1 6.003052126 7.700360883 10391 coronin 2B "GO:0003093,GO:0003779,GO:0005515,GO:0005737,GO:0005925,GO:0010812,GO:0015629,GO:0016020,GO:0017166,GO:0030036,GO:0032956,GO:0048041,GO:0051015,GO:0051497,GO:0080135,GO:1904950,GO:1904951,GO:1990147" regulation of glomerular filtration|actin binding|protein binding|cytoplasm|focal adhesion|negative regulation of cell-substrate adhesion|actin cytoskeleton|membrane|vinculin binding|actin cytoskeleton organization|regulation of actin cytoskeleton organization|focal adhesion assembly|actin filament binding|negative regulation of stress fiber assembly|regulation of cellular response to stress|negative regulation of establishment of protein localization|positive regulation of establishment of protein localization|talin binding CORO6 79.2255549 73.86938567 84.58172413 1.145017295 0.195369389 0.718828452 1 0.923249027 1.039446362 84940 coronin 6 "GO:0005515,GO:0007015,GO:0016477,GO:0051015" protein binding|actin filament organization|cell migration|actin filament binding CORO7 78.66068857 84.27352449 73.04785266 0.866794798 -0.206237599 0.702827837 1 1.23051248 1.04875368 79585 coronin 7 "GO:0000139,GO:0003779,GO:0005515,GO:0005794,GO:0005802,GO:0005829,GO:0006895,GO:0007015,GO:0015031,GO:0016020,GO:0016021,GO:0030041,GO:0031410,GO:0051015" Golgi membrane|actin binding|protein binding|Golgi apparatus|trans-Golgi network|cytosol|Golgi to endosome transport|actin filament organization|protein transport|membrane|integral component of membrane|actin filament polymerization|cytoplasmic vesicle|actin filament binding COTL1 7435.602893 7106.026818 7765.178968 1.092759592 0.127976042 0.602185352 1 205.8825141 221.215355 23406 coactosin like F-actin binding protein 1 "GO:0003779,GO:0005515,GO:0005576,GO:0005634,GO:0005829,GO:0005884,GO:0005886,GO:0008150,GO:0019899,GO:0030833,GO:0030864,GO:0034774,GO:0043312,GO:0050832,GO:0051015,GO:0070062,GO:1904813" actin binding|protein binding|extracellular region|nucleus|cytosol|actin filament|plasma membrane|biological_process|enzyme binding|regulation of actin filament polymerization|cortical actin cytoskeleton|secretory granule lumen|neutrophil degranulation|defense response to fungus|actin filament binding|extracellular exosome|ficolin-1-rich granule lumen COX10 267.4920066 272.5884373 262.395576 0.96260714 -0.054980971 0.87786036 1 5.019856418 4.75129015 1352 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 "GO:0000266,GO:0004129,GO:0004311,GO:0005730,GO:0005739,GO:0005743,GO:0005829,GO:0006123,GO:0006783,GO:0006784,GO:0008495,GO:0008535,GO:0016021,GO:0045333,GO:0048034,GO:0070069,GO:1902600" "mitochondrial fission|cytochrome-c oxidase activity|farnesyltranstransferase activity|nucleolus|mitochondrion|mitochondrial inner membrane|cytosol|mitochondrial electron transport, cytochrome c to oxygen|heme biosynthetic process|heme A biosynthetic process|protoheme IX farnesyltransferase activity|respiratory chain complex IV assembly|integral component of membrane|cellular respiration|heme O biosynthetic process|cytochrome complex|proton transmembrane transport" "hsa00190,hsa00860,hsa04714" Oxidative phosphorylation|Porphyrin and chlorophyll metabolism|Thermogenesis COX11 837.0826647 805.2803452 868.8849842 1.078984467 0.109674096 0.664301353 1 3.823857281 4.056841553 1353 cytochrome c oxidase copper chaperone COX11 "GO:0005507,GO:0005515,GO:0005739,GO:0009055,GO:0022900,GO:0031304,GO:0031305,GO:0032991,GO:0033132,GO:0055065" copper ion binding|protein binding|mitochondrion|electron transfer activity|electron transport chain|intrinsic component of mitochondrial inner membrane|integral component of mitochondrial inner membrane|protein-containing complex|negative regulation of glucokinase activity|metal ion homeostasis "hsa00190,hsa04714" Oxidative phosphorylation|Thermogenesis COX14 410.8872976 315.2454064 506.5291888 1.606777382 0.684170058 0.017317422 0.770503287 30.92659549 48.86062323 84987 cytochrome c oxidase assembly factor COX14 "GO:0005515,GO:0005739,GO:0016021,GO:0031966,GO:0033617" protein binding|mitochondrion|integral component of membrane|mitochondrial membrane|mitochondrial cytochrome c oxidase assembly hsa04714 Thermogenesis COX15 2654.388577 2792.470861 2516.306293 0.901103868 -0.150234684 0.525668957 1 20.46258925 18.13036799 1355 cytochrome c oxidase assembly homolog COX15 "GO:0004129,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005746,GO:0006123,GO:0006783,GO:0006784,GO:0007585,GO:0008535,GO:0016021,GO:0016627,GO:0016653,GO:0020037,GO:0045333,GO:0055114,GO:0060090,GO:0070069,GO:1902600" "cytochrome-c oxidase activity|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respirasome|mitochondrial electron transport, cytochrome c to oxygen|heme biosynthetic process|heme A biosynthetic process|respiratory gaseous exchange by respiratory system|respiratory chain complex IV assembly|integral component of membrane|oxidoreductase activity, acting on the CH-CH group of donors|oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor|heme binding|cellular respiration|oxidation-reduction process|molecular adaptor activity|cytochrome complex|proton transmembrane transport" "hsa00190,hsa00860,hsa04714" Oxidative phosphorylation|Porphyrin and chlorophyll metabolism|Thermogenesis COX16 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.099805231 0.151098779 51241 cytochrome c oxidase assembly factor COX16 "GO:0003674,GO:0005515,GO:0031305,GO:0033617" molecular_function|protein binding|integral component of mitochondrial inner membrane|mitochondrial cytochrome c oxidase assembly hsa04714 Thermogenesis COX17 218.6667816 189.3553266 247.9782366 1.309592083 0.389117505 0.269754886 1 11.08064228 14.26829744 10063 cytochrome c oxidase copper chaperone COX17 "GO:0005507,GO:0005515,GO:0005737,GO:0005758,GO:0006091,GO:0006825,GO:0008284,GO:0016531,GO:0033617,GO:1903136,GO:1904960" copper ion binding|protein binding|cytoplasm|mitochondrial intermembrane space|generation of precursor metabolites and energy|copper ion transport|positive regulation of cell population proliferation|copper chaperone activity|mitochondrial cytochrome c oxidase assembly|cuprous ion binding|positive regulation of cytochrome-c oxidase activity "hsa00190,hsa04714" Oxidative phosphorylation|Thermogenesis COX18 236.6758798 220.5677431 252.7840164 1.146060674 0.196683425 0.571038398 1 1.713185135 1.930559035 285521 cytochrome c oxidase assembly factor COX18 "GO:0005515,GO:0008535,GO:0031305,GO:0032977,GO:0032979,GO:0033617,GO:0051204,GO:0051205" protein binding|respiratory chain complex IV assembly|integral component of mitochondrial inner membrane|membrane insertase activity|protein insertion into mitochondrial inner membrane from matrix|mitochondrial cytochrome c oxidase assembly|protein insertion into mitochondrial membrane|protein insertion into membrane hsa04714 Thermogenesis COX19 337.7501262 338.1345119 337.3657406 0.997726433 -0.003283798 1 1 3.729203851 3.658463959 90639 cytochrome c oxidase assembly factor COX19 "GO:0005515,GO:0005739,GO:0005758,GO:0005829,GO:0006878,GO:0033617" protein binding|mitochondrion|mitochondrial intermembrane space|cytosol|cellular copper ion homeostasis|mitochondrial cytochrome c oxidase assembly hsa04714 Thermogenesis COX20 530.7229781 584.712602 476.7333542 0.815329364 -0.29454512 0.275225517 1 12.28061272 9.845194448 116228 cytochrome c oxidase assembly factor COX20 "GO:0005515,GO:0005739,GO:0005743,GO:0016021,GO:0033617" protein binding|mitochondrion|mitochondrial inner membrane|integral component of membrane|mitochondrial cytochrome c oxidase assembly hsa04714 Thermogenesis COX4I1 5541.305125 5166.695341 5915.914909 1.145009434 0.195359485 0.418019899 1 245.0995861 275.9451857 1327 cytochrome c oxidase subunit 4I1 "GO:0004129,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005751,GO:0005829,GO:0006091,GO:0006123,GO:0007584,GO:0016020,GO:0016021,GO:1902600" "cytochrome-c oxidase activity|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex IV|cytosol|generation of precursor metabolites and energy|mitochondrial electron transport, cytochrome c to oxygen|response to nutrient|membrane|integral component of membrane|proton transmembrane transport" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX5A 1538.886373 1402.477914 1675.294831 1.19452493 0.256436963 0.282229042 1 63.80875415 74.94568988 9377 cytochrome c oxidase subunit 5A "GO:0004129,GO:0005515,GO:0005743,GO:0005751,GO:0006123,GO:0009055,GO:0046872,GO:1902600" "cytochrome-c oxidase activity|protein binding|mitochondrial inner membrane|mitochondrial respiratory chain complex IV|mitochondrial electron transport, cytochrome c to oxygen|electron transfer activity|metal ion binding|proton transmembrane transport" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX5B 1152.528673 1037.292641 1267.764706 1.222186156 0.289464045 0.233565738 1 80.22956781 96.41464166 1329 cytochrome c oxidase subunit 5B "GO:0004129,GO:0005515,GO:0005739,GO:0005743,GO:0006123,GO:0007585,GO:0046872" "cytochrome-c oxidase activity|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial electron transport, cytochrome c to oxygen|respiratory gaseous exchange by respiratory system|metal ion binding" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX6A1 3112.42908 2768.541342 3456.316818 1.248425214 0.320109401 0.176630965 1 275.1433204 337.7479207 1337 cytochrome c oxidase subunit 6A1 "GO:0004129,GO:0005515,GO:0005739,GO:0005743,GO:0005751,GO:0006091,GO:0006123,GO:0016021,GO:0030234,GO:0050790,GO:1902600" "cytochrome-c oxidase activity|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex IV|generation of precursor metabolites and energy|mitochondrial electron transport, cytochrome c to oxygen|integral component of membrane|enzyme regulator activity|regulation of catalytic activity|proton transmembrane transport" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX6B1 1609.338221 1384.790878 1833.885564 1.324305058 0.40523549 0.088625089 1 151.4420984 197.1995116 1340 cytochrome c oxidase subunit 6B1 "GO:0004129,GO:0005739,GO:0005743,GO:0006123,GO:0021762,GO:0045277,GO:1902600" "cytochrome-c oxidase activity|mitochondrion|mitochondrial inner membrane|mitochondrial electron transport, cytochrome c to oxygen|substantia nigra development|respiratory chain complex IV|proton transmembrane transport" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX6B2 19.45586248 18.72744989 20.18427508 1.0777909 0.108077311 0.966287111 1 0.476382069 0.504848532 125965 cytochrome c oxidase subunit 6B2 "GO:0005515,GO:0005739,GO:0006119,GO:0030061,GO:0045277" protein binding|mitochondrion|oxidative phosphorylation|mitochondrial crista|respiratory chain complex IV "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX6C 1923.203487 1663.621798 2182.785176 1.31206815 0.391842657 0.098037132 1 95.87952243 123.6953672 1345 cytochrome c oxidase subunit 6C "GO:0004129,GO:0005515,GO:0005739,GO:0005743,GO:0006091,GO:0006123,GO:0016021,GO:1902600" "cytochrome-c oxidase activity|protein binding|mitochondrion|mitochondrial inner membrane|generation of precursor metabolites and energy|mitochondrial electron transport, cytochrome c to oxygen|integral component of membrane|proton transmembrane transport" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX7A2 1174.402517 1018.565191 1330.239843 1.305993818 0.385148068 0.112334795 1 43.24498982 55.53261173 1347 cytochrome c oxidase subunit 7A2 "GO:0002082,GO:0004129,GO:0005515,GO:0005746,GO:0006119,GO:0016021,GO:0022900,GO:0097250,GO:1902600" regulation of oxidative phosphorylation|cytochrome-c oxidase activity|protein binding|mitochondrial respirasome|oxidative phosphorylation|integral component of membrane|electron transport chain|mitochondrial respirasome assembly|proton transmembrane transport "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX7A2L 1782.834474 1763.501531 1802.167417 1.021925632 0.031290212 0.897373969 1 36.77797403 36.9554311 9167 cytochrome c oxidase subunit 7A2 like "GO:0002082,GO:0004129,GO:0005730,GO:0005739,GO:0005743,GO:0005746,GO:0006123,GO:0097250,GO:1902600" "regulation of oxidative phosphorylation|cytochrome-c oxidase activity|nucleolus|mitochondrion|mitochondrial inner membrane|mitochondrial respirasome|mitochondrial electron transport, cytochrome c to oxygen|mitochondrial respirasome assembly|proton transmembrane transport" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX7B 2284.135213 2017.362518 2550.907907 1.264476704 0.338540457 0.152170666 1 44.05193529 54.77053758 1349 cytochrome c oxidase subunit 7B "GO:0004129,GO:0005515,GO:0005743,GO:0005746,GO:0006123,GO:0007417,GO:0016021,GO:0045277,GO:1902600" "cytochrome-c oxidase activity|protein binding|mitochondrial inner membrane|mitochondrial respirasome|mitochondrial electron transport, cytochrome c to oxygen|central nervous system development|integral component of membrane|respiratory chain complex IV|proton transmembrane transport" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX7C 3168.166679 2692.591128 3643.742229 1.353247506 0.436425729 0.065677172 1 228.4557071 303.9837902 1350 cytochrome c oxidase subunit 7C "GO:0004129,GO:0005515,GO:0005739,GO:0005743,GO:0005751,GO:0006091,GO:0006123,GO:0016021,GO:1902600" "cytochrome-c oxidase activity|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex IV|generation of precursor metabolites and energy|mitochondrial electron transport, cytochrome c to oxygen|integral component of membrane|proton transmembrane transport" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases COX8A 2673.083886 2412.719794 2933.447978 1.215826216 0.281937032 0.233232 1 260.6526741 311.6053224 1351 cytochrome c oxidase subunit 8A "GO:0004129,GO:0005515,GO:0005739,GO:0005743,GO:0006091,GO:0006123,GO:0016021,GO:0045277,GO:1902600" "cytochrome-c oxidase activity|protein binding|mitochondrion|mitochondrial inner membrane|generation of precursor metabolites and energy|mitochondrial electron transport, cytochrome c to oxygen|integral component of membrane|respiratory chain complex IV|proton transmembrane transport" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases CP 32.13897389 48.89945248 15.3784953 0.314492178 -1.668903962 0.020302324 0.810058917 0.480868602 0.148698795 1356 ceruloplasmin "GO:0004322,GO:0005507,GO:0005576,GO:0005615,GO:0005765,GO:0005788,GO:0005886,GO:0006825,GO:0006826,GO:0006879,GO:0016491,GO:0043687,GO:0044267,GO:0051087,GO:0055072,GO:0055114,GO:0070062,GO:0072562" ferroxidase activity|copper ion binding|extracellular region|extracellular space|lysosomal membrane|endoplasmic reticulum lumen|plasma membrane|copper ion transport|iron ion transport|cellular iron ion homeostasis|oxidoreductase activity|post-translational protein modification|cellular protein metabolic process|chaperone binding|iron ion homeostasis|oxidation-reduction process|extracellular exosome|blood microparticle "hsa00860,hsa04216" Porphyrin and chlorophyll metabolism|Ferroptosis CPA4 2022.120835 2065.221557 1979.020113 0.958260438 -0.061510287 0.796544968 1 39.50432931 37.22197645 51200 carboxypeptidase A4 "GO:0004181,GO:0005575,GO:0005615,GO:0006508,GO:0008270,GO:0016573" metallocarboxypeptidase activity|cellular_component|extracellular space|proteolysis|zinc ion binding|histone acetylation CPAMD8 7.045123399 8.323311061 5.766935736 0.692865579 -0.529352609 0.780164403 1 0.071807277 0.048920245 27151 C3 and PZP like alpha-2-macroglobulin domain containing 8 "GO:0001654,GO:0004867,GO:0005615,GO:0005886,GO:0010951" eye development|serine-type endopeptidase inhibitor activity|extracellular space|plasma membrane|negative regulation of endopeptidase activity CPD 3183.026311 3284.586628 3081.465995 0.938159453 -0.092094945 0.698264195 1 19.04316692 17.56657167 1362 carboxypeptidase D "GO:0004181,GO:0004185,GO:0005615,GO:0005886,GO:0006518,GO:0008270,GO:0016020,GO:0016021,GO:0016485,GO:0070062" metallocarboxypeptidase activity|serine-type carboxypeptidase activity|extracellular space|plasma membrane|peptide metabolic process|zinc ion binding|membrane|integral component of membrane|protein processing|extracellular exosome CPE 165.5012636 143.5771158 187.4254114 1.305398917 0.384490747 0.328020223 1 2.967640119 3.809128819 1363 carboxypeptidase E "GO:0003214,GO:0004180,GO:0004181,GO:0005515,GO:0005615,GO:0005634,GO:0005794,GO:0005886,GO:0006464,GO:0006518,GO:0007218,GO:0008270,GO:0016055,GO:0016485,GO:0030658,GO:0042043,GO:0050839,GO:0070062,GO:0072657" cardiac left ventricle morphogenesis|carboxypeptidase activity|metallocarboxypeptidase activity|protein binding|extracellular space|nucleus|Golgi apparatus|plasma membrane|cellular protein modification process|peptide metabolic process|neuropeptide signaling pathway|zinc ion binding|Wnt signaling pathway|protein processing|transport vesicle membrane|neurexin family protein binding|cell adhesion molecule binding|extracellular exosome|protein localization to membrane hsa04940 Type I diabetes mellitus CPEB1 1.922311912 0 3.844623824 Inf Inf 0.288176591 1 0 0.036808445 64506 cytoplasmic polyadenylation element binding protein 1 "GO:0000900,GO:0000932,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006397,GO:0006412,GO:0008135,GO:0014069,GO:0016020,GO:0030425,GO:0032869,GO:0035925,GO:0043005,GO:0043022,GO:0045202,GO:0046872,GO:0071230,GO:0071456,GO:1900365,GO:1990124,GO:2000766" "translation repressor activity, mRNA regulatory element binding|P-body|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|mRNA processing|translation|translation factor activity, RNA binding|postsynaptic density|membrane|dendrite|cellular response to insulin stimulus|mRNA 3'-UTR AU-rich region binding|neuron projection|ribosome binding|synapse|metal ion binding|cellular response to amino acid stimulus|cellular response to hypoxia|positive regulation of mRNA polyadenylation|messenger ribonucleoprotein complex|negative regulation of cytoplasmic translation" "hsa04114,hsa04914" Oocyte meiosis|Progesterone-mediated oocyte maturation CPEB2 216.3381193 203.921121 228.7551175 1.121782366 0.165792809 0.646764879 1 1.657209599 1.82792018 132864 cytoplasmic polyadenylation element binding protein 2 "GO:0000900,GO:0003723,GO:0003730,GO:0005095,GO:0005634,GO:0005737,GO:0006412,GO:0008135,GO:0032869,GO:0034260,GO:0034599,GO:0035925,GO:0043005,GO:0043022,GO:0043023,GO:0043024,GO:0045202,GO:0071243,GO:0071456,GO:1900248,GO:1990124,GO:2000766" "translation repressor activity, mRNA regulatory element binding|RNA binding|mRNA 3'-UTR binding|GTPase inhibitor activity|nucleus|cytoplasm|translation|translation factor activity, RNA binding|cellular response to insulin stimulus|negative regulation of GTPase activity|cellular response to oxidative stress|mRNA 3'-UTR AU-rich region binding|neuron projection|ribosome binding|ribosomal large subunit binding|ribosomal small subunit binding|synapse|cellular response to arsenic-containing substance|cellular response to hypoxia|negative regulation of cytoplasmic translational elongation|messenger ribonucleoprotein complex|negative regulation of cytoplasmic translation" "hsa04114,hsa04914" Oocyte meiosis|Progesterone-mediated oocyte maturation CPEB3 104.8446427 103.0009744 106.6883111 1.035799047 0.050744136 0.934298386 1 0.498998974 0.508213665 22849 cytoplasmic polyadenylation element binding protein 3 "GO:0000122,GO:0000900,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0007616,GO:0008135,GO:0014069,GO:0017148,GO:0030014,GO:0030425,GO:0030496,GO:0035613,GO:0035925,GO:0043005,GO:0043022,GO:0045202,GO:0045727,GO:0048167,GO:0060213,GO:0060998,GO:0060999,GO:0061158,GO:0071230,GO:0097440,GO:1900153,GO:1900248,GO:1900365,GO:1990124,GO:2000766" "negative regulation of transcription by RNA polymerase II|translation repressor activity, mRNA regulatory element binding|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|translation|long-term memory|translation factor activity, RNA binding|postsynaptic density|negative regulation of translation|CCR4-NOT complex|dendrite|midbody|RNA stem-loop binding|mRNA 3'-UTR AU-rich region binding|neuron projection|ribosome binding|synapse|positive regulation of translation|regulation of synaptic plasticity|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of dendritic spine development|positive regulation of dendritic spine development|3'-UTR-mediated mRNA destabilization|cellular response to amino acid stimulus|apical dendrite|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of cytoplasmic translational elongation|positive regulation of mRNA polyadenylation|messenger ribonucleoprotein complex|negative regulation of cytoplasmic translation" "hsa04114,hsa04914" Oocyte meiosis|Progesterone-mediated oocyte maturation CPEB4 365.4500418 371.4277561 359.4723275 0.967812237 -0.047200914 0.88266911 1 2.04207445 1.943273191 80315 cytoplasmic polyadenylation element binding protein 4 "GO:0000900,GO:0002931,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0006412,GO:0008135,GO:0014069,GO:0030425,GO:0030426,GO:0035235,GO:0036294,GO:0042149,GO:0043005,GO:0043022,GO:0043197,GO:0043524,GO:0045202,GO:0046872,GO:0048471,GO:0071230,GO:1990124,GO:2000766" "translation repressor activity, mRNA regulatory element binding|response to ischemia|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|endoplasmic reticulum|translation|translation factor activity, RNA binding|postsynaptic density|dendrite|growth cone|ionotropic glutamate receptor signaling pathway|cellular response to decreased oxygen levels|cellular response to glucose starvation|neuron projection|ribosome binding|dendritic spine|negative regulation of neuron apoptotic process|synapse|metal ion binding|perinuclear region of cytoplasm|cellular response to amino acid stimulus|messenger ribonucleoprotein complex|negative regulation of cytoplasmic translation" "hsa04114,hsa04914" Oocyte meiosis|Progesterone-mediated oocyte maturation CPED1 1567.899074 1457.61985 1678.178299 1.15131411 0.203281493 0.393897165 1 11.22194062 12.70378023 79974 cadherin like and PC-esterase domain containing 1 GO:0005783 endoplasmic reticulum CPLANE1 1195.992084 1307.80025 1084.183918 0.829013389 -0.270532692 0.264115867 1 4.556099989 3.713863779 65250 ciliogenesis and planar polarity effector 1 "GO:0016021,GO:0035869,GO:0060271" integral component of membrane|ciliary transition zone|cilium assembly CPLANE2 43.03375153 44.73779695 41.32970611 0.923820772 -0.11431511 0.893166705 1 1.292676773 1.174218306 79363 ciliogenesis and planar polarity effector 2 "GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0006887,GO:0015031,GO:0017157,GO:0031338,GO:0034613,GO:0036064,GO:0060271" GTPase activity|protein binding|GTP binding|cytoplasm|exocytosis|protein transport|regulation of exocytosis|regulation of vesicle fusion|cellular protein localization|ciliary basal body|cilium assembly CPLX1 6.445658531 5.202069413 7.689247648 1.478113235 0.563756795 0.78195947 1 0.122571693 0.178143125 10815 complexin 1 "GO:0000149,GO:0005326,GO:0005515,GO:0005829,GO:0006887,GO:0007268,GO:0007269,GO:0014047,GO:0016079,GO:0017075,GO:0017157,GO:0030073,GO:0030425,GO:0031201,GO:0031630,GO:0043195,GO:0043204,GO:0044305,GO:0046928,GO:0070032,GO:0070554,GO:0098685,GO:0098794,GO:0098967,GO:0098978" SNARE binding|neurotransmitter transmembrane transporter activity|protein binding|cytosol|exocytosis|chemical synaptic transmission|neurotransmitter secretion|glutamate secretion|synaptic vesicle exocytosis|syntaxin-1 binding|regulation of exocytosis|insulin secretion|dendrite|SNARE complex|regulation of synaptic vesicle fusion to presynaptic active zone membrane|terminal bouton|perikaryon|calyx of Held|regulation of neurotransmitter secretion|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex|synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex|Schaffer collateral - CA1 synapse|postsynapse|exocytic insertion of neurotransmitter receptor to postsynaptic membrane|glutamatergic synapse hsa04721 Synaptic vesicle cycle CPM 253.7137611 276.7500928 230.6774294 0.833522501 -0.26270695 0.433989972 1 2.123295544 1.740199161 1368 carboxypeptidase M "GO:0004180,GO:0004181,GO:0005576,GO:0005615,GO:0005886,GO:0006518,GO:0008270,GO:0009653,GO:0009986,GO:0016485,GO:0031225,GO:0070062" carboxypeptidase activity|metallocarboxypeptidase activity|extracellular region|extracellular space|plasma membrane|peptide metabolic process|zinc ion binding|anatomical structure morphogenesis|cell surface|protein processing|anchored component of membrane|extracellular exosome CPN2 28.37863841 38.49531366 18.26196316 0.47439445 -1.075840962 0.148432361 1 0.6631453 0.309328171 1370 carboxypeptidase N subunit 2 "GO:0005576,GO:0005615,GO:0030234,GO:0030449,GO:0031012,GO:0050790,GO:0050821,GO:0070062,GO:0072562" extracellular region|extracellular space|enzyme regulator activity|regulation of complement activation|extracellular matrix|regulation of catalytic activity|protein stabilization|extracellular exosome|blood microparticle CPNE1 5128.179098 4742.206477 5514.15172 1.162781871 0.217580483 0.365322791 1 104.6229202 119.617926 8904 copine 1 "GO:0001786,GO:0004175,GO:0005215,GO:0005509,GO:0005515,GO:0005544,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006629,GO:0010629,GO:0016020,GO:0016192,GO:0031965,GO:0035577,GO:0042802,GO:0043122,GO:0043312,GO:0043392,GO:0045666,GO:0046474,GO:0051059,GO:0051897,GO:0070062,GO:0071277,GO:1901223,GO:1903265,GO:1990138" phosphatidylserine binding|endopeptidase activity|transporter activity|calcium ion binding|protein binding|calcium-dependent phospholipid binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|proteolysis|lipid metabolic process|negative regulation of gene expression|membrane|vesicle-mediated transport|nuclear membrane|azurophil granule membrane|identical protein binding|regulation of I-kappaB kinase/NF-kappaB signaling|neutrophil degranulation|negative regulation of DNA binding|positive regulation of neuron differentiation|glycerophospholipid biosynthetic process|NF-kappaB binding|positive regulation of protein kinase B signaling|extracellular exosome|cellular response to calcium ion|negative regulation of NIK/NF-kappaB signaling|positive regulation of tumor necrosis factor-mediated signaling pathway|neuron projection extension CPNE2 1073.123867 1110.121613 1036.126121 0.933344697 -0.099518108 0.68624046 1 22.77783551 20.90382184 221184 copine 2 "GO:0005515,GO:0005544,GO:0005634,GO:0005737,GO:0005886,GO:0046872,GO:0070062,GO:0071277" protein binding|calcium-dependent phospholipid binding|nucleus|cytoplasm|plasma membrane|metal ion binding|extracellular exosome|cellular response to calcium ion CPNE3 4722.39449 4485.224248 4959.564733 1.105756247 0.145033393 0.545025835 1 45.08724329 49.02123665 8895 copine 3 "GO:0003723,GO:0004674,GO:0005515,GO:0005544,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0005925,GO:0006468,GO:0030054,GO:0030335,GO:0030971,GO:0035577,GO:0038128,GO:0043312,GO:0046474,GO:0046872,GO:0048306,GO:0070062,GO:0071277,GO:0071363" RNA binding|protein serine/threonine kinase activity|protein binding|calcium-dependent phospholipid binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|cytosol|plasma membrane|focal adhesion|protein phosphorylation|cell junction|positive regulation of cell migration|receptor tyrosine kinase binding|azurophil granule membrane|ERBB2 signaling pathway|neutrophil degranulation|glycerophospholipid biosynthetic process|metal ion binding|calcium-dependent protein binding|extracellular exosome|cellular response to calcium ion|cellular response to growth factor stimulus CPNE5 9.007064274 9.363724944 8.650403604 0.923820772 -0.11431511 1 1 0.09092518 0.082592968 57699 copine 5 "GO:0003674,GO:0005544,GO:0005886,GO:0030154,GO:0043005,GO:0043204,GO:0046872,GO:0070062,GO:0071277,GO:1903861" molecular_function|calcium-dependent phospholipid binding|plasma membrane|cell differentiation|neuron projection|perikaryon|metal ion binding|extracellular exosome|cellular response to calcium ion|positive regulation of dendrite extension CPNE7 801.1380816 858.3414532 743.9347099 0.866711851 -0.206375663 0.413201095 1 10.55000133 8.99080189 27132 copine 7 "GO:0005215,GO:0005515,GO:0005544,GO:0005634,GO:0005737,GO:0005886,GO:0006629,GO:0046474,GO:0046872,GO:0070062,GO:0071277" transporter activity|protein binding|calcium-dependent phospholipid binding|nucleus|cytoplasm|plasma membrane|lipid metabolic process|glycerophospholipid biosynthetic process|metal ion binding|extracellular exosome|cellular response to calcium ion CPNE8 622.0177027 622.1675018 621.8679035 0.99951846 -0.000694882 1 1 4.872184311 4.788348014 144402 copine 8 "GO:0003674,GO:0005515,GO:0005544,GO:0005886,GO:0008150,GO:0046872,GO:0070062,GO:0071277" molecular_function|protein binding|calcium-dependent phospholipid binding|plasma membrane|biological_process|metal ion binding|extracellular exosome|cellular response to calcium ion CPO 6.445658531 5.202069413 7.689247648 1.478113235 0.563756795 0.78195947 1 0.012665947 0.018408421 130749 carboxypeptidase O "GO:0004181,GO:0005615,GO:0006508,GO:0008270,GO:0016324,GO:0046658" metallocarboxypeptidase activity|extracellular space|proteolysis|zinc ion binding|apical plasma membrane|anchored component of plasma membrane CPOX 910.5909737 855.2202115 965.9617358 1.1294889 0.175670092 0.480334069 1 9.337465397 10.37008106 1371 coproporphyrinogen oxidase "GO:0004109,GO:0005737,GO:0005739,GO:0005758,GO:0005829,GO:0006782,GO:0006783,GO:0042803,GO:0055114" coproporphyrinogen oxidase activity|cytoplasm|mitochondrion|mitochondrial intermembrane space|cytosol|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|protein homodimerization activity|oxidation-reduction process hsa00860 Porphyrin and chlorophyll metabolism CPQ 98.43358276 111.3242854 85.54288008 0.76841167 -0.380048665 0.425024828 1 3.07514105 2.323433095 10404 carboxypeptidase Q "GO:0004180,GO:0005615,GO:0005737,GO:0005764,GO:0005783,GO:0005794,GO:0006508,GO:0006590,GO:0042246,GO:0042803,GO:0043171,GO:0043231,GO:0046872,GO:0070062,GO:0070573" carboxypeptidase activity|extracellular space|cytoplasm|lysosome|endoplasmic reticulum|Golgi apparatus|proteolysis|thyroid hormone generation|tissue regeneration|protein homodimerization activity|peptide catabolic process|intracellular membrane-bounded organelle|metal ion binding|extracellular exosome|metallodipeptidase activity CPS1 547.4293509 569.1063938 525.7523079 0.923820772 -0.11431511 0.674015804 1 5.037678266 4.576034912 1373 carbamoyl-phosphate synthase 1 "GO:0000050,GO:0004087,GO:0004088,GO:0004175,GO:0005509,GO:0005515,GO:0005524,GO:0005543,GO:0005730,GO:0005737,GO:0005743,GO:0005759,GO:0006207,GO:0006508,GO:0006541,GO:0006807,GO:0007494,GO:0009636,GO:0010043,GO:0014075,GO:0016595,GO:0019240,GO:0019433,GO:0032094,GO:0032496,GO:0032991,GO:0042311,GO:0042493,GO:0042594,GO:0042645,GO:0043200,GO:0044344,GO:0044877,GO:0046209,GO:0050667,GO:0055081,GO:0060416,GO:0070365,GO:0070409,GO:0071242,GO:0071320,GO:0071377,GO:0071400,GO:0071548,GO:0072341" urea cycle|carbamoyl-phosphate synthase (ammonia) activity|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|endopeptidase activity|calcium ion binding|protein binding|ATP binding|phospholipid binding|nucleolus|cytoplasm|mitochondrial inner membrane|mitochondrial matrix|'de novo' pyrimidine nucleobase biosynthetic process|proteolysis|glutamine metabolic process|nitrogen compound metabolic process|midgut development|response to toxic substance|response to zinc ion|response to amine|glutamate binding|citrulline biosynthetic process|triglyceride catabolic process|response to food|response to lipopolysaccharide|protein-containing complex|vasodilation|response to drug|response to starvation|mitochondrial nucleoid|response to amino acid|cellular response to fibroblast growth factor stimulus|protein-containing complex binding|nitric oxide metabolic process|homocysteine metabolic process|anion homeostasis|response to growth hormone|hepatocyte differentiation|carbamoyl phosphate biosynthetic process|cellular response to ammonium ion|cellular response to cAMP|cellular response to glucagon stimulus|cellular response to oleic acid|response to dexamethasone|modified amino acid binding "hsa00220,hsa00250,hsa00910" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|Nitrogen metabolism" CPSF1 2465.371018 2271.223506 2659.51853 1.17096293 0.227695404 0.335589987 1 25.72390156 29.61768869 29894 cleavage and polyadenylation specific factor 1 "GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005847,GO:0006369,GO:0006378,GO:0006388,GO:0006406,GO:0019899,GO:0031124,GO:0035925,GO:0098789" "mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|tRNA splicing, via endonucleolytic cleavage and ligation|mRNA export from nucleus|enzyme binding|mRNA 3'-end processing|mRNA 3'-UTR AU-rich region binding|pre-mRNA cleavage required for polyadenylation" hsa03015 mRNA surveillance pathway CPSF2 1722.876084 1779.107739 1666.644428 0.936786677 -0.094207536 0.692996516 1 7.301984941 6.725937343 53981 cleavage and polyadenylation specific factor 2 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005847,GO:0006369,GO:0006378,GO:0006398,GO:0006406,GO:0016020,GO:0031124,GO:0098789" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA 3'-end processing by stem-loop binding and cleavage|mRNA export from nucleus|membrane|mRNA 3'-end processing|pre-mRNA cleavage required for polyadenylation" hsa03015 mRNA surveillance pathway CPSF3 1560.169583 1557.499582 1562.839584 1.003428574 0.004937926 0.986518719 1 35.38564927 34.9128105 51692 cleavage and polyadenylation specific factor 3 "GO:0000398,GO:0003723,GO:0004521,GO:0005515,GO:0005654,GO:0005847,GO:0006369,GO:0006378,GO:0006379,GO:0006398,GO:0006406,GO:0008409,GO:0031124,GO:0046872,GO:0090502" "mRNA splicing, via spliceosome|RNA binding|endoribonuclease activity|protein binding|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA cleavage|mRNA 3'-end processing by stem-loop binding and cleavage|mRNA export from nucleus|5'-3' exonuclease activity|mRNA 3'-end processing|metal ion binding|RNA phosphodiester bond hydrolysis, endonucleolytic" hsa03015 mRNA surveillance pathway CPSF4 782.7924444 767.8254454 797.7594435 1.038985421 0.05517541 0.831500534 1 19.42058427 19.84005737 10898 cleavage and polyadenylation specific factor 4 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005847,GO:0006369,GO:0006388,GO:0006406,GO:0008270,GO:0031124,GO:0043231,GO:0046778,GO:0098789,GO:1990837" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation|mRNA export from nucleus|zinc ion binding|mRNA 3'-end processing|intracellular membrane-bounded organelle|modification by virus of host mRNA processing|pre-mRNA cleavage required for polyadenylation|sequence-specific double-stranded DNA binding" "hsa03015,hsa05164" mRNA surveillance pathway|Influenza A CPSF6 2209.60857 2407.517724 2011.699416 0.835590698 -0.259131663 0.273075528 1 19.17969788 15.75819743 11052 cleavage and polyadenylation specific factor 6 "GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005726,GO:0005737,GO:0005847,GO:0005849,GO:0006397,GO:0016020,GO:0016607,GO:0035061,GO:0042382,GO:0043023,GO:0046833,GO:0051262,GO:0051290,GO:0098789,GO:0110104,GO:1990120,GO:1990448,GO:1990904" RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|perichromatin fibrils|cytoplasm|mRNA cleavage and polyadenylation specificity factor complex|mRNA cleavage factor complex|mRNA processing|membrane|nuclear speck|interchromatin granule|paraspeckles|ribosomal large subunit binding|positive regulation of RNA export from nucleus|protein tetramerization|protein heterotetramerization|pre-mRNA cleavage required for polyadenylation|mRNA alternative polyadenylation|messenger ribonucleoprotein complex assembly|exon-exon junction complex binding|ribonucleoprotein complex hsa03015 mRNA surveillance pathway CPSF7 1866.785937 1936.210236 1797.361638 0.92828847 -0.107354895 0.651667553 1 26.54984113 24.23349546 79869 cleavage and polyadenylation specific factor 7 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005847,GO:0005849,GO:0006369,GO:0016020,GO:0031124,GO:0051262,GO:0051290,GO:0098789,GO:0110104,GO:1990120" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|mRNA cleavage and polyadenylation specificity factor complex|mRNA cleavage factor complex|termination of RNA polymerase II transcription|membrane|mRNA 3'-end processing|protein tetramerization|protein heterotetramerization|pre-mRNA cleavage required for polyadenylation|mRNA alternative polyadenylation|messenger ribonucleoprotein complex assembly" hsa03015 mRNA surveillance pathway CPT1A 2781.897684 2405.436897 3158.358471 1.313008242 0.392875973 0.09688927 1 21.87318899 28.23909252 1374 carnitine palmitoyltransferase 1A "GO:0001676,GO:0004095,GO:0005739,GO:0005741,GO:0006006,GO:0006631,GO:0006635,GO:0006641,GO:0006853,GO:0007623,GO:0009437,GO:0010883,GO:0014070,GO:0016020,GO:0019216,GO:0030855,GO:0031307,GO:0031667,GO:0032000,GO:0042493,GO:0042755,GO:0042802,GO:0043279,GO:0045471,GO:0046677,GO:0050796,GO:0071398,GO:0097421,GO:1904772,GO:1990698" long-chain fatty acid metabolic process|carnitine O-palmitoyltransferase activity|mitochondrion|mitochondrial outer membrane|glucose metabolic process|fatty acid metabolic process|fatty acid beta-oxidation|triglyceride metabolic process|carnitine shuttle|circadian rhythm|carnitine metabolic process|regulation of lipid storage|response to organic cyclic compound|membrane|regulation of lipid metabolic process|epithelial cell differentiation|integral component of mitochondrial outer membrane|response to nutrient levels|positive regulation of fatty acid beta-oxidation|response to drug|eating behavior|identical protein binding|response to alkaloid|response to ethanol|response to antibiotic|regulation of insulin secretion|cellular response to fatty acid|liver regeneration|response to tetrachloromethane|palmitoleoyltransferase activity "hsa00071,hsa03320,hsa04152,hsa04714,hsa04920,hsa04922,hsa04931" Fatty acid degradation|PPAR signaling pathway|AMPK signaling pathway|Thermogenesis|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance CPT1B 52.15970269 57.22276355 47.09664184 0.823040324 -0.280964979 0.653959473 1 1.110499534 0.89869158 1375 carnitine palmitoyltransferase 1B "GO:0004095,GO:0005515,GO:0005739,GO:0005741,GO:0006631,GO:0006635,GO:0006853,GO:0009437,GO:0009637,GO:0015909,GO:0016021" carnitine O-palmitoyltransferase activity|protein binding|mitochondrion|mitochondrial outer membrane|fatty acid metabolic process|fatty acid beta-oxidation|carnitine shuttle|carnitine metabolic process|response to blue light|long-chain fatty acid transport|integral component of membrane "hsa00071,hsa03320,hsa04152,hsa04714,hsa04920,hsa04922,hsa04931" Fatty acid degradation|PPAR signaling pathway|AMPK signaling pathway|Thermogenesis|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance CPT1C 67.49353861 68.66731625 66.31976096 0.965812625 -0.050184772 0.955592869 1 1.023930836 0.972377003 126129 carnitine palmitoyltransferase 1C "GO:0004095,GO:0005515,GO:0005739,GO:0005741,GO:0005783,GO:0006631,GO:0006635,GO:0009437,GO:0030176,GO:0030424,GO:0030425,GO:0032281,GO:0098794,GO:0098978,GO:0099072" carnitine O-palmitoyltransferase activity|protein binding|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|fatty acid metabolic process|fatty acid beta-oxidation|carnitine metabolic process|integral component of endoplasmic reticulum membrane|axon|dendrite|AMPA glutamate receptor complex|postsynapse|glutamatergic synapse|regulation of postsynaptic membrane neurotransmitter receptor levels "hsa00071,hsa03320,hsa04152,hsa04714,hsa04920,hsa04922" Fatty acid degradation|PPAR signaling pathway|AMPK signaling pathway|Thermogenesis|Adipocytokine signaling pathway|Glucagon signaling pathway CPT2 362.4426566 380.791481 344.0938322 0.903627968 -0.146199171 0.628352262 1 7.727049992 6.865537835 1376 carnitine palmitoyltransferase 2 "GO:0001676,GO:0004095,GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0005743,GO:0006635,GO:0006853,GO:0009437,GO:0016746,GO:0019216,GO:0120162" "long-chain fatty acid metabolic process|carnitine O-palmitoyltransferase activity|protein binding|nucleoplasm|nucleolus|mitochondrion|mitochondrial inner membrane|fatty acid beta-oxidation|carnitine shuttle|carnitine metabolic process|transferase activity, transferring acyl groups|regulation of lipid metabolic process|positive regulation of cold-induced thermogenesis" "hsa00071,hsa03320,hsa04714" Fatty acid degradation|PPAR signaling pathway|Thermogenesis CPTP 634.6567691 562.8639105 706.4496277 1.255098461 0.327800546 0.208202337 1 9.878004737 12.190407 80772 ceramide-1-phosphate transfer protein "GO:0005543,GO:0005640,GO:0005794,GO:0005829,GO:0005886,GO:0006687,GO:0010008,GO:0010507,GO:0016020,GO:0032691,GO:0035627,GO:0046836,GO:0120009,GO:1900226,GO:1902387,GO:1902388,GO:1902389" phospholipid binding|nuclear outer membrane|Golgi apparatus|cytosol|plasma membrane|glycosphingolipid metabolic process|endosome membrane|negative regulation of autophagy|membrane|negative regulation of interleukin-1 beta production|ceramide transport|glycolipid transport|intermembrane lipid transfer|negative regulation of NLRP3 inflammasome complex assembly|ceramide 1-phosphate binding|ceramide 1-phosphate transfer activity|ceramide 1-phosphate transport CPVL 74.13231154 91.55642167 56.7082014 0.619379836 -0.691103679 0.18436737 1 1.026727874 0.625293038 54504 carboxypeptidase vitellogenic like "GO:0004185,GO:0006508,GO:0070062" serine-type carboxypeptidase activity|proteolysis|extracellular exosome CPZ 92.96920186 56.18234966 129.7560541 2.309551929 1.207612985 0.012652096 0.667587345 1.287397485 2.923557007 8532 carboxypeptidase Z "GO:0004181,GO:0005615,GO:0006508,GO:0006518,GO:0008270,GO:0016055,GO:0016485" metallocarboxypeptidase activity|extracellular space|proteolysis|peptide metabolic process|zinc ion binding|Wnt signaling pathway|protein processing CR1 5.122811487 8.323311061 1.922311912 0.230955193 -2.11431511 0.224307997 1 0.044701601 0.010151308 1378 complement C3b/C4b receptor 1 (Knops blood group) "GO:0001618,GO:0001851,GO:0001855,GO:0001861,GO:0001970,GO:0001971,GO:0002430,GO:0002435,GO:0002638,GO:0004877,GO:0005515,GO:0005856,GO:0005886,GO:0005887,GO:0006957,GO:0006958,GO:0007009,GO:0008284,GO:0009986,GO:0030449,GO:0030667,GO:0032689,GO:0032703,GO:0042130,GO:0043312,GO:0044853,GO:0045589,GO:0045591,GO:0045916,GO:0045918,GO:0045957,GO:0045959,GO:0046718,GO:0070062,GO:0101003,GO:1900004,GO:1900005,GO:1900099,GO:1904669" "virus receptor activity|complement component C3b binding|complement component C4b binding|complement component C4b receptor activity|positive regulation of activation of membrane attack complex|negative regulation of activation of membrane attack complex|complement receptor mediated signaling pathway|immune complex clearance by erythrocytes|negative regulation of immunoglobulin production|complement component C3b receptor activity|protein binding|cytoskeleton|plasma membrane|integral component of plasma membrane|complement activation, alternative pathway|complement activation, classical pathway|plasma membrane organization|positive regulation of cell population proliferation|cell surface|regulation of complement activation|secretory granule membrane|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|negative regulation of T cell proliferation|neutrophil degranulation|plasma membrane raft|regulation of regulatory T cell differentiation|positive regulation of regulatory T cell differentiation|negative regulation of complement activation|negative regulation of cytolysis|negative regulation of complement activation, alternative pathway|negative regulation of complement activation, classical pathway|viral entry into host cell|extracellular exosome|ficolin-1-rich granule membrane|negative regulation of serine-type endopeptidase activity|positive regulation of serine-type endopeptidase activity|negative regulation of plasma cell differentiation|ATP export" "hsa04610,hsa04640,hsa05134,hsa05140,hsa05144,hsa05152" Complement and coagulation cascades|Hematopoietic cell lineage|Legionellosis|Leishmaniasis|Malaria|Tuberculosis CR1L 5.04355356 6.242483296 3.844623824 0.615880514 -0.699277611 0.760739355 1 0.182148639 0.110304587 1379 complement C3b/C4b receptor 1 like "GO:0005515,GO:0005576,GO:0005737,GO:0016020,GO:0030449,GO:0043235,GO:1903659" protein binding|extracellular region|cytoplasm|membrane|regulation of complement activation|receptor complex|regulation of complement-dependent cytotoxicity "hsa04610,hsa04640,hsa05134,hsa05140,hsa05144,hsa05152" Complement and coagulation cascades|Hematopoietic cell lineage|Legionellosis|Leishmaniasis|Malaria|Tuberculosis CRABP2 227.0001535 181.0320156 272.9682915 1.507845398 0.592488514 0.087559638 1 9.201281856 13.64194605 1382 cellular retinoic acid binding protein 2 "GO:0001972,GO:0005501,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0006355,GO:0007165,GO:0008544,GO:0016918,GO:0019841,GO:0030332,GO:0035115,GO:0042573,GO:0048672,GO:0070062" "retinoic acid binding|retinoid binding|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|regulation of transcription, DNA-templated|signal transduction|epidermis development|retinal binding|retinol binding|cyclin binding|embryonic forelimb morphogenesis|retinoic acid metabolic process|positive regulation of collateral sprouting|extracellular exosome" CRACD 585.7711791 629.450399 542.0919592 0.861214736 -0.21555509 0.416152818 1 4.104668978 3.475847949 57482 capping protein inhibiting regulator of actin dynamics "GO:0005515,GO:0005829,GO:0010669,GO:0030277,GO:0030838,GO:2000813" protein binding|cytosol|epithelial structure maintenance|maintenance of gastrointestinal epithelium|positive regulation of actin filament polymerization|negative regulation of barbed-end actin filament capping CRACR2A 422.8464125 452.5800389 393.112786 0.868603898 -0.203229668 0.478566599 1 4.473673805 3.82082606 84766 calcium release activated channel regulator 2A "GO:0002115,GO:0002250,GO:0005509,GO:0005515,GO:0005576,GO:0005737,GO:0016020,GO:0032237,GO:0035580,GO:0043312,GO:0051928" store-operated calcium entry|adaptive immune response|calcium ion binding|protein binding|extracellular region|cytoplasm|membrane|activation of store-operated calcium channel activity|specific granule lumen|neutrophil degranulation|positive regulation of calcium ion transport CRACR2B 72.70063844 66.58648849 78.81478839 1.183645364 0.243236895 0.659207144 1 0.924934542 1.076474579 283229 calcium release activated channel regulator 2B "GO:0002115,GO:0005509,GO:0005515,GO:0005737,GO:0034613,GO:2001256" store-operated calcium entry|calcium ion binding|protein binding|cytoplasm|cellular protein localization|regulation of store-operated calcium entry CRADD 486.9765196 420.3272086 553.6258307 1.317130605 0.397398409 0.148562752 1 4.873363153 6.311444901 8738 CASP2 and RIPK1 domain containing adaptor with death domain "GO:0002020,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006919,GO:0006977,GO:0008625,GO:0030674,GO:0042981,GO:0043065,GO:0070513,GO:0071260,GO:0097190,GO:2001235" "protease binding|protein binding|nucleus|cytoplasm|cytosol|activation of cysteine-type endopeptidase activity involved in apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|extrinsic apoptotic signaling pathway via death domain receptors|protein-macromolecule adaptor activity|regulation of apoptotic process|positive regulation of apoptotic process|death domain binding|cellular response to mechanical stimulus|apoptotic signaling pathway|positive regulation of apoptotic signaling pathway" CRAMP1 731.5882529 824.0077951 639.1687107 0.775682845 -0.3664612 0.149901904 1 5.516279674 4.20728219 57585 cramped chromatin regulator homolog 1 "GO:0003677,GO:0003682,GO:0005634,GO:0007389" DNA binding|chromatin binding|nucleus|pattern specification process CRAT 1921.1164 1873.785403 1968.447398 1.050519123 0.071102424 0.765616854 1 29.95820344 30.9450299 1384 carnitine O-acetyltransferase "GO:0003997,GO:0004092,GO:0005739,GO:0005743,GO:0005777,GO:0005782,GO:0005783,GO:0005829,GO:0006625,GO:0008458,GO:0019254,GO:0033540,GO:0046459,GO:0051791" "acyl-CoA oxidase activity|carnitine O-acetyltransferase activity|mitochondrion|mitochondrial inner membrane|peroxisome|peroxisomal matrix|endoplasmic reticulum|cytosol|protein targeting to peroxisome|carnitine O-octanoyltransferase activity|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA oxidase|short-chain fatty acid metabolic process|medium-chain fatty acid metabolic process" hsa04146 Peroxisome CRB1 4.082397604 6.242483296 1.922311912 0.307940257 -1.699277611 0.406294648 1 0.058100778 0.017592177 23418 crumbs cell polarity complex component 1 "GO:0001750,GO:0001917,GO:0001974,GO:0005509,GO:0005515,GO:0005576,GO:0005886,GO:0005902,GO:0005912,GO:0007009,GO:0007157,GO:0007163,GO:0007267,GO:0010001,GO:0010467,GO:0010842,GO:0016021,GO:0016324,GO:0032991,GO:0034613,GO:0035845,GO:0042462,GO:0045197,GO:0045494,GO:0050908,GO:0060060,GO:0061159,GO:0071482" photoreceptor outer segment|photoreceptor inner segment|blood vessel remodeling|calcium ion binding|protein binding|extracellular region|plasma membrane|microvillus|adherens junction|plasma membrane organization|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|establishment or maintenance of cell polarity|cell-cell signaling|glial cell differentiation|gene expression|retina layer formation|integral component of membrane|apical plasma membrane|protein-containing complex|cellular protein localization|photoreceptor cell outer segment organization|eye photoreceptor cell development|establishment or maintenance of epithelial cell apical/basal polarity|photoreceptor cell maintenance|detection of light stimulus involved in visual perception|post-embryonic retina morphogenesis in camera-type eye|establishment of bipolar cell polarity involved in cell morphogenesis|cellular response to light stimulus hsa04390 Hippo signaling pathway CRBN 657.1841834 611.763363 702.6050038 1.14849147 0.199740141 0.441991772 1 8.460400702 9.554102253 51185 cereblon "GO:0005515,GO:0005634,GO:0005737,GO:0016020,GO:0016567,GO:0031464,GO:0043161,GO:0046872" protein binding|nucleus|cytoplasm|membrane|protein ubiquitination|Cul4A-RING E3 ubiquitin ligase complex|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding CRCP 736.032956 726.2088901 745.8570219 1.027055758 0.038514506 0.884949094 1 13.82676909 13.96323059 27297 CGRP receptor component "GO:0000166,GO:0001635,GO:0001669,GO:0003899,GO:0005515,GO:0005654,GO:0005666,GO:0005829,GO:0005886,GO:0006383,GO:0006384,GO:0007218,GO:0009360,GO:0032481,GO:0045087,GO:0051607" nucleotide binding|calcitonin gene-related peptide receptor activity|acrosomal vesicle|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|RNA polymerase III complex|cytosol|plasma membrane|transcription by RNA polymerase III|transcription initiation from RNA polymerase III promoter|neuropeptide signaling pathway|DNA polymerase III complex|positive regulation of type I interferon production|innate immune response|defense response to virus CREB1 1263.054735 1352.538047 1173.571422 0.867680894 -0.204763533 0.396453497 1 7.321479839 6.246404205 1385 cAMP responsive element binding protein 1 "GO:0000785,GO:0000791,GO:0000978,GO:0000981,GO:0001102,GO:0001225,GO:0001228,GO:0001666,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005759,GO:0006357,GO:0006366,GO:0006468,GO:0007165,GO:0007179,GO:0007409,GO:0007568,GO:0007595,GO:0007613,GO:0007623,GO:0008361,GO:0008542,GO:0010033,GO:0010944,GO:0014823,GO:0016032,GO:0019899,GO:0021983,GO:0030424,GO:0030544,GO:0032916,GO:0033363,GO:0033762,GO:0034670,GO:0035035,GO:0035094,GO:0035497,GO:0035729,GO:0036120,GO:0040018,GO:0042493,GO:0042752,GO:0042802,GO:0043065,GO:0045600,GO:0045672,GO:0045893,GO:0045899,GO:0045944,GO:0046887,GO:0046889,GO:0048145,GO:0050821,GO:0055025,GO:0060251,GO:0060430,GO:0060509,GO:0071294,GO:0071300,GO:0071398,GO:1900273,GO:1901215,GO:1902065,GO:1990090,GO:1990314,GO:1990589,GO:1990763,GO:1990830,GO:1990837" "chromatin|euchromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription coactivator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|response to hypoxia|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|mitochondrial matrix|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|protein phosphorylation|signal transduction|transforming growth factor beta receptor signaling pathway|axonogenesis|aging|lactation|memory|circadian rhythm|regulation of cell size|visual learning|response to organic substance|negative regulation of transcription by competitive promoter binding|response to activity|viral process|enzyme binding|pituitary gland development|axon|Hsp70 protein binding|positive regulation of transforming growth factor beta3 production|secretory granule organization|response to glucagon|chemotaxis to arachidonic acid|histone acetyltransferase binding|response to nicotine|cAMP response element binding|cellular response to hepatocyte growth factor stimulus|cellular response to platelet-derived growth factor stimulus|positive regulation of multicellular organism growth|response to drug|regulation of circadian rhythm|identical protein binding|positive regulation of apoptotic process|positive regulation of fat cell differentiation|positive regulation of osteoclast differentiation|positive regulation of transcription, DNA-templated|positive regulation of RNA polymerase II transcription preinitiation complex assembly|positive regulation of transcription by RNA polymerase II|positive regulation of hormone secretion|positive regulation of lipid biosynthetic process|regulation of fibroblast proliferation|protein stabilization|positive regulation of cardiac muscle tissue development|regulation of glial cell proliferation|lung saccule development|type I pneumocyte differentiation|cellular response to zinc ion|cellular response to retinoic acid|cellular response to fatty acid|positive regulation of long-term synaptic potentiation|negative regulation of neuron death|response to L-glutamate|cellular response to nerve growth factor stimulus|cellular response to insulin-like growth factor stimulus|ATF4-CREB1 transcription factor complex|arrestin family protein binding|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding" "hsa04022,hsa04024,hsa04151,hsa04152,hsa04211,hsa04261,hsa04380,hsa04612,hsa04668,hsa04710,hsa04713,hsa04714,hsa04725,hsa04728,hsa04911,hsa04915,hsa04916,hsa04918,hsa04922,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04931,hsa04934,hsa04935,hsa04962,hsa05016,hsa05020,hsa05030,hsa05031,hsa05034,hsa05152,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05203,hsa05215" "cGMP-PKG signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|Osteoclast differentiation|Antigen processing and presentation|TNF signaling pathway|Circadian rhythm|Circadian entrainment|Thermogenesis|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|Cushing syndrome|Growth hormone synthesis, secretion and action|Vasopressin-regulated water reabsorption|Huntington disease|Prion disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Viral carcinogenesis|Prostate cancer" TF_bZIP CREB3 1232.957574 1205.83969 1260.075458 1.044977594 0.063472009 0.795588438 1 43.01701071 44.19960466 10488 cAMP responsive element binding protein 3 "GO:0000139,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005783,GO:0005789,GO:0005829,GO:0006357,GO:0006935,GO:0006990,GO:0016021,GO:0016032,GO:0030968,GO:0035497,GO:0045944,GO:0090026,GO:1902236,GO:1990837" "Golgi membrane|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|regulation of transcription by RNA polymerase II|chemotaxis|positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|integral component of membrane|viral process|endoplasmic reticulum unfolded protein response|cAMP response element binding|positive regulation of transcription by RNA polymerase II|positive regulation of monocyte chemotaxis|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|sequence-specific double-stranded DNA binding" "hsa04022,hsa04024,hsa04151,hsa04152,hsa04211,hsa04261,hsa04668,hsa04714,hsa04725,hsa04728,hsa04911,hsa04915,hsa04916,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04931,hsa04934,hsa04935,hsa04962,hsa05016,hsa05020,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05165,hsa05166,hsa05203,hsa05215" "cGMP-PKG signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Thermogenesis|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|Cushing syndrome|Growth hormone synthesis, secretion and action|Vasopressin-regulated water reabsorption|Huntington disease|Prion disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis|Prostate cancer" TF_bZIP CREB3L1 5.563760501 7.282897178 3.844623824 0.527897584 -0.921670032 0.614283311 1 0.125136779 0.064953989 90993 cAMP responsive element binding protein 3 like 1 "GO:0000122,GO:0000785,GO:0000976,GO:0000981,GO:0001227,GO:0001228,GO:0001649,GO:0003682,GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0006357,GO:0007275,GO:0010629,GO:0016020,GO:0016021,GO:0016032,GO:0030968,GO:0032967,GO:0035497,GO:0040037,GO:0045892,GO:0046332,GO:0070278,GO:1902236,GO:1903671,GO:1990440,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|osteoblast differentiation|chromatin binding|protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|regulation of transcription by RNA polymerase II|multicellular organism development|negative regulation of gene expression|membrane|integral component of membrane|viral process|endoplasmic reticulum unfolded protein response|positive regulation of collagen biosynthetic process|cAMP response element binding|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of transcription, DNA-templated|SMAD binding|extracellular matrix constituent secretion|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|negative regulation of sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|sequence-specific double-stranded DNA binding" "hsa04022,hsa04024,hsa04151,hsa04152,hsa04211,hsa04261,hsa04668,hsa04714,hsa04725,hsa04728,hsa04911,hsa04915,hsa04916,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04931,hsa04934,hsa04935,hsa04962,hsa05016,hsa05020,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05165,hsa05166,hsa05203,hsa05215" "cGMP-PKG signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Thermogenesis|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|Cushing syndrome|Growth hormone synthesis, secretion and action|Vasopressin-regulated water reabsorption|Huntington disease|Prion disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis|Prostate cancer" CREB3L2 4388.270722 4191.827533 4584.71391 1.093726751 0.129252351 0.588737386 1 26.10386595 28.07274261 64764 cAMP responsive element binding protein 3 like 2 "GO:0000785,GO:0000976,GO:0000981,GO:0001228,GO:0002062,GO:0005634,GO:0005654,GO:0005783,GO:0005789,GO:0006357,GO:0006888,GO:0009611,GO:0010976,GO:0016021,GO:0030968,GO:0034976,GO:0035497,GO:0045893,GO:0045944,GO:0051216,GO:0097038" "chromatin|transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|chondrocyte differentiation|nucleus|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|regulation of transcription by RNA polymerase II|endoplasmic reticulum to Golgi vesicle-mediated transport|response to wounding|positive regulation of neuron projection development|integral component of membrane|endoplasmic reticulum unfolded protein response|response to endoplasmic reticulum stress|cAMP response element binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cartilage development|perinuclear endoplasmic reticulum" "hsa04022,hsa04024,hsa04151,hsa04152,hsa04211,hsa04261,hsa04668,hsa04714,hsa04725,hsa04728,hsa04911,hsa04915,hsa04916,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04931,hsa04934,hsa04935,hsa04962,hsa05016,hsa05020,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05165,hsa05166,hsa05203,hsa05215" "cGMP-PKG signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Thermogenesis|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|Cushing syndrome|Growth hormone synthesis, secretion and action|Vasopressin-regulated water reabsorption|Huntington disease|Prion disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis|Prostate cancer" CREB3L4 198.4328168 213.2848459 183.5807876 0.860730573 -0.216366381 0.559421322 1 4.964073365 4.201231365 148327 cAMP responsive element binding protein 3 like 4 "GO:0000139,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005783,GO:0005789,GO:0005794,GO:0006357,GO:0007283,GO:0016021,GO:0030968,GO:0031965,GO:0035497,GO:0045944,GO:1990837" "Golgi membrane|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|regulation of transcription by RNA polymerase II|spermatogenesis|integral component of membrane|endoplasmic reticulum unfolded protein response|nuclear membrane|cAMP response element binding|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" "hsa04022,hsa04024,hsa04151,hsa04152,hsa04211,hsa04261,hsa04668,hsa04714,hsa04725,hsa04728,hsa04911,hsa04915,hsa04916,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04931,hsa04934,hsa04935,hsa04962,hsa05016,hsa05020,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05165,hsa05166,hsa05203,hsa05215" "cGMP-PKG signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Thermogenesis|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|Cushing syndrome|Growth hormone synthesis, secretion and action|Vasopressin-regulated water reabsorption|Huntington disease|Prion disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis|Prostate cancer" CREB5 1340.491956 1392.073775 1288.910137 0.925892119 -0.111083989 0.645452663 1 5.590940612 5.089984327 9586 cAMP responsive element binding protein 5 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0035497,GO:0045893,GO:0046872,GO:0070062,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|cAMP response element binding|positive regulation of transcription, DNA-templated|metal ion binding|extracellular exosome|sequence-specific double-stranded DNA binding" "hsa04022,hsa04024,hsa04151,hsa04152,hsa04211,hsa04261,hsa04668,hsa04714,hsa04725,hsa04728,hsa04911,hsa04915,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04931,hsa04934,hsa04935,hsa04962,hsa05016,hsa05020,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05165,hsa05166,hsa05203,hsa05215" "cGMP-PKG signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Thermogenesis|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|Cushing syndrome|Growth hormone synthesis, secretion and action|Vasopressin-regulated water reabsorption|Huntington disease|Prion disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis|Prostate cancer" CREBBP 1043.990435 1354.618875 733.3619944 0.541378839 -0.885289596 0.000322034 0.084688763 6.338200919 3.373948563 1387 CREB binding protein "GO:0000122,GO:0000123,GO:0000785,GO:0001085,GO:0001102,GO:0001666,GO:0002039,GO:0002223,GO:0003682,GO:0003684,GO:0003713,GO:0003714,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006355,GO:0006367,GO:0006473,GO:0007165,GO:0007219,GO:0007221,GO:0008134,GO:0008270,GO:0008589,GO:0016032,GO:0016407,GO:0016573,GO:0016604,GO:0018076,GO:0018215,GO:0019216,GO:0030511,GO:0031490,GO:0031648,GO:0032481,GO:0034644,GO:0042592,GO:0042733,GO:0042981,GO:0043426,GO:0045637,GO:0045747,GO:0045893,GO:0045944,GO:0048511,GO:0061418,GO:0061733,GO:0065003,GO:1900034,GO:1904837,GO:1990258" "negative regulation of transcription by RNA polymerase II|histone acetyltransferase complex|chromatin|RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|response to hypoxia|p53 binding|stimulatory C-type lectin receptor signaling pathway|chromatin binding|damaged DNA binding|transcription coactivator activity|transcription corepressor activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|protein acetylation|signal transduction|Notch signaling pathway|positive regulation of transcription of Notch receptor target|transcription factor binding|zinc ion binding|regulation of smoothened signaling pathway|viral process|acetyltransferase activity|histone acetylation|nuclear body|N-terminal peptidyl-lysine acetylation|protein phosphopantetheinylation|regulation of lipid metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|chromatin DNA binding|protein destabilization|positive regulation of type I interferon production|cellular response to UV|homeostatic process|embryonic digit morphogenesis|regulation of apoptotic process|MRF binding|regulation of myeloid cell differentiation|positive regulation of Notch signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|rhythmic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|peptide-lysine-N-acetyltransferase activity|protein-containing complex assembly|regulation of cellular response to heat|beta-catenin-TCF complex assembly|histone glutamine methylation" "hsa04024,hsa04066,hsa04068,hsa04110,hsa04310,hsa04330,hsa04350,hsa04520,hsa04630,hsa04720,hsa04916,hsa04919,hsa04922,hsa04935,hsa05016,hsa05152,hsa05161,hsa05164,hsa05165,hsa05166,hsa05167,hsa05200,hsa05203,hsa05206,hsa05211,hsa05215" "cAMP signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Cell cycle|Wnt signaling pathway|Notch signaling pathway|TGF-beta signaling pathway|Adherens junction|JAK-STAT signaling pathway|Long-term potentiation|Melanogenesis|Thyroid hormone signaling pathway|Glucagon signaling pathway|Growth hormone synthesis, secretion and action|Huntington disease|Tuberculosis|Hepatitis B|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Viral carcinogenesis|MicroRNAs in cancer|Renal cell carcinoma|Prostate cancer" other CREBL2 1430.137355 1348.376392 1511.898319 1.121273205 0.165137843 0.490985071 1 19.08763125 21.04430847 1389 cAMP responsive element binding protein like 2 "GO:0000785,GO:0000981,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006351,GO:0006355,GO:0006357,GO:0007049,GO:0007165,GO:0030154,GO:0033138,GO:0045600,GO:0045893,GO:0046326,GO:0046889,GO:0050821" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|cell cycle|signal transduction|cell differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of glucose import|positive regulation of lipid biosynthetic process|protein stabilization" CREBRF 576.2439079 619.0462602 533.4415556 0.861715174 -0.214717007 0.419538935 1 4.072653001 3.450740713 153222 CREB3 regulatory factor "GO:0000977,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0030968,GO:0045944" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|endoplasmic reticulum unfolded protein response|positive regulation of transcription by RNA polymerase II" CREBZF 1765.113454 1613.681932 1916.544976 1.187684474 0.248151613 0.295716017 1 12.02111096 14.03837578 58487 CREB/ATF bZIP transcription factor "GO:0000785,GO:0000976,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006357,GO:0009615,GO:0042802,GO:0045814,GO:0045892,GO:0051090" "chromatin|transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|response to virus|identical protein binding|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|regulation of DNA-binding transcription factor activity" CREG1 524.6981469 628.4099851 420.9863087 0.66992301 -0.57793279 0.032464585 0.920517339 17.03254745 11.21955627 8804 cellular repressor of E1A stimulated genes 1 "GO:0003714,GO:0005576,GO:0005615,GO:0006357,GO:0007275,GO:0035578,GO:0040008,GO:0043312,GO:0045892,GO:0070062" "transcription corepressor activity|extracellular region|extracellular space|regulation of transcription by RNA polymerase II|multicellular organism development|azurophil granule lumen|regulation of growth|neutrophil degranulation|negative regulation of transcription, DNA-templated|extracellular exosome" CREG2 9.448013289 8.323311061 10.57271552 1.270253561 0.345116509 0.853432744 1 0.056320504 0.070344173 200407 cellular repressor of E1A stimulated genes 2 "GO:0005615,GO:0005783,GO:0005794" extracellular space|endoplasmic reticulum|Golgi apparatus CRELD1 646.0767841 547.2577023 744.8958659 1.361142772 0.444818401 0.08652405 1 10.6242771 14.21917009 78987 cysteine rich with EGF like domains 1 "GO:0003197,GO:0003279,GO:0003756,GO:0005201,GO:0005509,GO:0005515,GO:0016021,GO:0018215,GO:0062023" endocardial cushion development|cardiac septum development|protein disulfide isomerase activity|extracellular matrix structural constituent|calcium ion binding|protein binding|integral component of membrane|protein phosphopantetheinylation|collagen-containing extracellular matrix CRELD2 652.3287138 635.6928823 668.9645454 1.05233921 0.073599816 0.781290556 1 17.81815167 18.43697141 79174 cysteine rich with EGF like domains 2 "GO:0003756,GO:0005509,GO:0005515,GO:0005615,GO:0005783,GO:0005794,GO:0018215" protein disulfide isomerase activity|calcium ion binding|protein binding|extracellular space|endoplasmic reticulum|Golgi apparatus|protein phosphopantetheinylation CREM 408.880083 426.5696919 391.1904741 0.917061108 -0.124910225 0.669480659 1 3.840938157 3.463432825 1390 cAMP responsive element modulator "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0005515,GO:0005634,GO:0005667,GO:0005737,GO:0006006,GO:0006355,GO:0006357,GO:0006631,GO:0007165,GO:0007275,GO:0007283,GO:0008140,GO:0030154,GO:0042752,GO:0048384,GO:0048511,GO:1990589,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|transcription regulator complex|cytoplasm|glucose metabolic process|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|fatty acid metabolic process|signal transduction|multicellular organism development|spermatogenesis|cAMP response element binding protein binding|cell differentiation|regulation of circadian rhythm|retinoic acid receptor signaling pathway|rhythmic process|ATF4-CREB1 transcription factor complex|sequence-specific double-stranded DNA binding" hsa04261 Adrenergic signaling in cardiomyocytes TF_bZIP CRIM1 4256.306851 4701.630336 3810.983366 0.810566355 -0.302997801 0.204189323 1 22.36140895 17.82210163 51232 cysteine rich transmembrane BMP regulator 1 "GO:0004867,GO:0005010,GO:0005520,GO:0005576,GO:0005886,GO:0007399,GO:0010951,GO:0016021,GO:0030165,GO:0030514,GO:0045668,GO:0048009" serine-type endopeptidase inhibitor activity|insulin-like growth factor-activated receptor activity|insulin-like growth factor binding|extracellular region|plasma membrane|nervous system development|negative regulation of endopeptidase activity|integral component of membrane|PDZ domain binding|negative regulation of BMP signaling pathway|negative regulation of osteoblast differentiation|insulin-like growth factor receptor signaling pathway CRIP1 914.0103541 717.885579 1110.135129 1.54639564 0.628909475 0.01133016 0.63010276 57.01225288 86.6882025 1396 cysteine rich protein 1 "GO:0005737,GO:0006955,GO:0007507,GO:0008270,GO:0008630,GO:0010033,GO:0010043,GO:0010468,GO:0042277,GO:0060741,GO:0071236,GO:0071493" cytoplasm|immune response|heart development|zinc ion binding|intrinsic apoptotic signaling pathway in response to DNA damage|response to organic substance|response to zinc ion|regulation of gene expression|peptide binding|prostate gland stromal morphogenesis|cellular response to antibiotic|cellular response to UV-B CRIP2 1929.876859 1700.036284 2159.717433 1.270394905 0.345277031 0.1448081 1 50.77101956 63.41993704 1397 cysteine rich protein 2 "GO:0005515,GO:0005938,GO:0008270,GO:0008284,GO:0030097" protein binding|cell cortex|zinc ion binding|positive regulation of cell population proliferation|hemopoiesis CRIPT 277.153256 248.658918 305.647594 1.229184123 0.297701037 0.360290594 1 2.098761574 2.536595542 9419 CXXC repeat containing interactor of PDZ3 domain "GO:0005515,GO:0005737,GO:0008017,GO:0014069,GO:0030165,GO:0030425,GO:0031122,GO:0035372,GO:0043025,GO:0043197,GO:0043198,GO:0044877,GO:0045184,GO:0097110,GO:1902897" protein binding|cytoplasm|microtubule binding|postsynaptic density|PDZ domain binding|dendrite|cytoplasmic microtubule organization|protein localization to microtubule|neuronal cell body|dendritic spine|dendritic shaft|protein-containing complex binding|establishment of protein localization|scaffold protein binding|regulation of postsynaptic density protein 95 clustering CRISPLD2 14.45193789 13.52538047 15.3784953 1.137010181 0.185245172 0.923276611 1 0.148952682 0.166526694 83716 cysteine rich secretory protein LCCL domain containing 2 "GO:0005539,GO:0005576,GO:0005615,GO:0008201,GO:0030133,GO:0030198,GO:0030324,GO:0031012,GO:0034774,GO:0043312,GO:0060325,GO:0070062,GO:1904813" glycosaminoglycan binding|extracellular region|extracellular space|heparin binding|transport vesicle|extracellular matrix organization|lung development|extracellular matrix|secretory granule lumen|neutrophil degranulation|face morphogenesis|extracellular exosome|ficolin-1-rich granule lumen CRK 2585.523116 2649.934159 2521.112073 0.951386684 -0.071896262 0.76222309 1 36.73301706 34.36250751 1398 "CRK proto-oncogene, adaptor protein" "GO:0000186,GO:0001764,GO:0001784,GO:0001878,GO:0005159,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006357,GO:0006629,GO:0008092,GO:0008360,GO:0009966,GO:0014911,GO:0015629,GO:0016020,GO:0016358,GO:0017124,GO:0019221,GO:0019900,GO:0021766,GO:0021987,GO:0030010,GO:0030036,GO:0030159,GO:0031625,GO:0032956,GO:0032991,GO:0033628,GO:0035020,GO:0035591,GO:0035685,GO:0035728,GO:0038026,GO:0038096,GO:0042169,GO:0042542,GO:0043087,GO:0043393,GO:0043621,GO:0045121,GO:0045309,GO:0045953,GO:0046875,GO:0048010,GO:0048013,GO:0050773,GO:0060326,GO:0061045,GO:0061847,GO:0070062,GO:0071560,GO:0071732,GO:0090630,GO:0097110,GO:0098749,GO:1900026,GO:1902531,GO:1990090,GO:1990314,GO:1990782,GO:1990859,GO:2000146,GO:2000404" activation of MAPKK activity|neuron migration|phosphotyrosine residue binding|response to yeast|insulin-like growth factor receptor binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|lipid metabolic process|cytoskeletal protein binding|regulation of cell shape|regulation of signal transduction|positive regulation of smooth muscle cell migration|actin cytoskeleton|membrane|dendrite development|SH3 domain binding|cytokine-mediated signaling pathway|kinase binding|hippocampus development|cerebral cortex development|establishment of cell polarity|actin cytoskeleton organization|signaling receptor complex adaptor activity|ubiquitin protein ligase binding|regulation of actin cytoskeleton organization|protein-containing complex|regulation of cell adhesion mediated by integrin|regulation of Rac protein signal transduction|signaling adaptor activity|helper T cell diapedesis|response to hepatocyte growth factor|reelin-mediated signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|SH2 domain binding|response to hydrogen peroxide|regulation of GTPase activity|regulation of protein binding|protein self-association|membrane raft|protein phosphorylated amino acid binding|negative regulation of natural killer cell mediated cytotoxicity|ephrin receptor binding|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|regulation of dendrite development|cell chemotaxis|negative regulation of wound healing|response to cholecystokinin|extracellular exosome|cellular response to transforming growth factor beta stimulus|cellular response to nitric oxide|activation of GTPase activity|scaffold protein binding|cerebellar neuron development|positive regulation of substrate adhesion-dependent cell spreading|regulation of intracellular signal transduction|cellular response to nerve growth factor stimulus|cellular response to insulin-like growth factor stimulus|protein tyrosine kinase binding|cellular response to endothelin|negative regulation of cell motility|regulation of T cell migration "hsa04010,hsa04012,hsa04015,hsa04062,hsa04510,hsa04666,hsa04722,hsa04810,hsa04910,hsa04935,hsa05100,hsa05131,hsa05135,hsa05163,hsa05170,hsa05200,hsa05206,hsa05211,hsa05220" "MAPK signaling pathway|ErbB signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|Focal adhesion|Fc gamma R-mediated phagocytosis|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|Insulin signaling pathway|Growth hormone synthesis, secretion and action|Bacterial invasion of epithelial cells|Shigellosis|Yersinia infection|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|MicroRNAs in cancer|Renal cell carcinoma|Chronic myeloid leukemia" CRKL 2671.259725 2566.701048 2775.818401 1.081473202 0.112997917 0.633534186 1 25.64210362 27.26720303 1399 "CRK like proto-oncogene, adaptor protein" "GO:0000186,GO:0000187,GO:0001558,GO:0001568,GO:0001655,GO:0001764,GO:0001783,GO:0001784,GO:0001933,GO:0001934,GO:0003151,GO:0003723,GO:0005515,GO:0005654,GO:0005829,GO:0006629,GO:0007254,GO:0007265,GO:0007283,GO:0007338,GO:0007416,GO:0008284,GO:0008543,GO:0008584,GO:0009952,GO:0010629,GO:0016358,GO:0019221,GO:0021766,GO:0021987,GO:0030010,GO:0031594,GO:0032991,GO:0033628,GO:0035556,GO:0035685,GO:0035690,GO:0038026,GO:0042802,GO:0045296,GO:0046579,GO:0048384,GO:0048538,GO:0050773,GO:0050852,GO:0060017,GO:0060326,GO:0060465,GO:0070374,GO:0071560,GO:0086100,GO:0090630,GO:0095500,GO:0098749,GO:0098761,GO:0098890,GO:1900026,GO:1903977,GO:1904393,GO:1904888,GO:2000404" activation of MAPKK activity|activation of MAPK activity|regulation of cell growth|blood vessel development|urogenital system development|neuron migration|B cell apoptotic process|phosphotyrosine residue binding|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|outflow tract morphogenesis|RNA binding|protein binding|nucleoplasm|cytosol|lipid metabolic process|JNK cascade|Ras protein signal transduction|spermatogenesis|single fertilization|synapse assembly|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|male gonad development|anterior/posterior pattern specification|negative regulation of gene expression|dendrite development|cytokine-mediated signaling pathway|hippocampus development|cerebral cortex development|establishment of cell polarity|neuromuscular junction|protein-containing complex|regulation of cell adhesion mediated by integrin|intracellular signal transduction|helper T cell diapedesis|cellular response to drug|reelin-mediated signaling pathway|identical protein binding|cadherin binding|positive regulation of Ras protein signal transduction|retinoic acid receptor signaling pathway|thymus development|regulation of dendrite development|T cell receptor signaling pathway|parathyroid gland development|cell chemotaxis|pharynx development|positive regulation of ERK1 and ERK2 cascade|cellular response to transforming growth factor beta stimulus|endothelin receptor signaling pathway|activation of GTPase activity|acetylcholine receptor signaling pathway|cerebellar neuron development|cellular response to interleukin-7|extrinsic component of postsynaptic membrane|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of glial cell migration|regulation of skeletal muscle acetylcholine-gated channel clustering|cranial skeletal system development|regulation of T cell migration "hsa04010,hsa04012,hsa04015,hsa04062,hsa04510,hsa04666,hsa04722,hsa04810,hsa04910,hsa04935,hsa05100,hsa05131,hsa05135,hsa05163,hsa05170,hsa05200,hsa05206,hsa05211,hsa05220" "MAPK signaling pathway|ErbB signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|Focal adhesion|Fc gamma R-mediated phagocytosis|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|Insulin signaling pathway|Growth hormone synthesis, secretion and action|Bacterial invasion of epithelial cells|Shigellosis|Yersinia infection|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|MicroRNAs in cancer|Renal cell carcinoma|Chronic myeloid leukemia" CRLF1 24.06349745 13.52538047 34.60161442 2.558272906 1.355170173 0.090905767 1 0.414603502 1.042920049 9244 cytokine receptor like factor 1 "GO:0001657,GO:0004896,GO:0005125,GO:0005127,GO:0005515,GO:0005576,GO:0005615,GO:0005829,GO:0008284,GO:0009897,GO:0019221,GO:0019955,GO:0042531,GO:0043235,GO:0043524,GO:0070106,GO:0097058,GO:2000672" ureteric bud development|cytokine receptor activity|cytokine activity|ciliary neurotrophic factor receptor binding|protein binding|extracellular region|extracellular space|cytosol|positive regulation of cell population proliferation|external side of plasma membrane|cytokine-mediated signaling pathway|cytokine binding|positive regulation of tyrosine phosphorylation of STAT protein|receptor complex|negative regulation of neuron apoptotic process|interleukin-27-mediated signaling pathway|CRLF-CLCF1 complex|negative regulation of motor neuron apoptotic process CRLF3 968.6214077 953.0191165 984.2236989 1.032742871 0.046481102 0.854395858 1 17.70305558 17.97676815 51379 cytokine receptor like factor 3 "GO:0000082,GO:0003677,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0030308,GO:0042802,GO:0045893,GO:0045944,GO:0046427,GO:0071158" "G1/S transition of mitotic cell cycle|DNA binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|negative regulation of cell growth|identical protein binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of receptor signaling pathway via JAK-STAT|positive regulation of cell cycle arrest" CRLS1 664.8684006 624.2483296 705.4884717 1.130140744 0.176502452 0.496616751 1 13.46604124 14.96386051 54675 cardiolipin synthase 1 "GO:0003841,GO:0005739,GO:0005743,GO:0008808,GO:0016021,GO:0032049,GO:0036148,GO:0043337,GO:0046474,GO:0047144,GO:0097068,GO:1905711" 1-acylglycerol-3-phosphate O-acyltransferase activity|mitochondrion|mitochondrial inner membrane|cardiolipin synthase activity|integral component of membrane|cardiolipin biosynthetic process|phosphatidylglycerol acyl-chain remodeling|CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity|glycerophospholipid biosynthetic process|2-acylglycerol-3-phosphate O-acyltransferase activity|response to thyroxine|response to phosphatidylethanolamine hsa00564 Glycerophospholipid metabolism CRNKL1 1085.039551 1057.060505 1113.018597 1.052937454 0.074419741 0.763432934 1 12.93291526 13.3896796 51340 crooked neck pre-mRNA splicing factor 1 "GO:0000245,GO:0000398,GO:0000974,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0016607,GO:0071007,GO:0071013,GO:0071014" "spliceosomal complex assembly|mRNA splicing, via spliceosome|Prp19 complex|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|nuclear speck|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|post-mRNA release spliceosomal complex" hsa03040 Spliceosome CROCC 235.8185195 261.1438845 210.4931544 0.806042825 -0.311071604 0.365341836 1 1.729342245 1.37059848 9696 "ciliary rootlet coiled-coil, rootletin" "GO:0001917,GO:0003779,GO:0005198,GO:0005200,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0007098,GO:0008104,GO:0010457,GO:0010669,GO:0015629,GO:0019894,GO:0032053,GO:0033365,GO:0035253,GO:0045494,GO:0045724,GO:0051656,GO:0070062,GO:0097729,GO:0120219,GO:1903566" photoreceptor inner segment|actin binding|structural molecule activity|structural constituent of cytoskeleton|protein binding|centrosome|centriole|cytosol|plasma membrane|centrosome cycle|protein localization|centriole-centriole cohesion|epithelial structure maintenance|actin cytoskeleton|kinesin binding|ciliary basal body organization|protein localization to organelle|ciliary rootlet|photoreceptor cell maintenance|positive regulation of cilium assembly|establishment of organelle localization|extracellular exosome|9+2 motile cilium|subapical part of cell|positive regulation of protein localization to cilium CROT 298.7295752 272.5884373 324.8707131 1.191799316 0.253141325 0.424883822 1 2.425399116 2.842218916 54677 carnitine O-octanoyltransferase "GO:0005777,GO:0005782,GO:0005829,GO:0006091,GO:0006625,GO:0006631,GO:0006635,GO:0008458,GO:0009437,GO:0015908,GO:0015936,GO:0033540,GO:0043231,GO:0051791" peroxisome|peroxisomal matrix|cytosol|generation of precursor metabolites and energy|protein targeting to peroxisome|fatty acid metabolic process|fatty acid beta-oxidation|carnitine O-octanoyltransferase activity|carnitine metabolic process|fatty acid transport|coenzyme A metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase|intracellular membrane-bounded organelle|medium-chain fatty acid metabolic process hsa04146 Peroxisome CRPPA 4.003139677 4.161655531 3.844623824 0.923820772 -0.11431511 1 1 0.038679886 0.035135334 729920 CDP-L-ribitol pyrophosphorylase A "GO:0005829,GO:0007411,GO:0008299,GO:0035269,GO:0042803,GO:0047349,GO:0070567" cytosol|axon guidance|isoprenoid biosynthetic process|protein O-linked mannosylation|protein homodimerization activity|D-ribitol-5-phosphate cytidylyltransferase activity|cytidylyltransferase activity "hsa00040,hsa00515" Pentose and glucuronate interconversions|Mannose type O-glycan biosynthesis CRTAP 8448.527524 8730.112889 8166.942158 0.935491014 -0.0962043 0.697961972 1 120.9527725 111.2568159 10491 cartilage associated protein "GO:0005515,GO:0005518,GO:0005615,GO:0005783,GO:0005788,GO:0007283,GO:0018400,GO:0030199,GO:0032991,GO:0050821,GO:0061077,GO:1901874" protein binding|collagen binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|spermatogenesis|peptidyl-proline hydroxylation to 3-hydroxy-L-proline|collagen fibril organization|protein-containing complex|protein stabilization|chaperone-mediated protein folding|negative regulation of post-translational protein modification CRTC1 190.1390738 222.6485709 157.6295768 0.707974797 -0.498230092 0.178853495 1 1.05630234 0.735321421 23373 CREB regulated transcription coactivator 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0007613,GO:0008140,GO:0014069,GO:0016032,GO:0016604,GO:0030425,GO:0032793,GO:0043025,GO:0043153,GO:0045944,GO:0048511,GO:0051289,GO:0097009,GO:0098978,GO:0099527,GO:1900006,GO:1900273,GO:1902631" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|memory|cAMP response element binding protein binding|postsynaptic density|viral process|nuclear body|dendrite|positive regulation of CREB transcription factor activity|neuronal cell body|entrainment of circadian clock by photoperiod|positive regulation of transcription by RNA polymerase II|rhythmic process|protein homotetramerization|energy homeostasis|glutamatergic synapse|postsynapse to nucleus signaling pathway|positive regulation of dendrite development|positive regulation of long-term synaptic potentiation|negative regulation of membrane hyperpolarization hsa05166 Human T-cell leukemia virus 1 infection CRTC2 854.5268965 846.8969005 862.1568925 1.018018713 0.025764081 0.922725409 1 15.62839939 15.64377068 200186 CREB regulated transcription coactivator 2 "GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006094,GO:0008140,GO:0016032,GO:0032793,GO:0042593,GO:0043970,GO:0045944,GO:0051289,GO:0070062,GO:1901998" chromatin binding|protein binding|nucleus|nucleoplasm|cytoplasm|gluconeogenesis|cAMP response element binding protein binding|viral process|positive regulation of CREB transcription factor activity|glucose homeostasis|histone H3-K9 acetylation|positive regulation of transcription by RNA polymerase II|protein homotetramerization|extracellular exosome|toxin transport "hsa04151,hsa04152,hsa04922,hsa04931,hsa05166" PI3K-Akt signaling pathway|AMPK signaling pathway|Glucagon signaling pathway|Insulin resistance|Human T-cell leukemia virus 1 infection CRTC3 781.6224684 888.5134558 674.7314811 0.759393655 -0.397080149 0.115457317 1 7.187862682 5.367078096 64784 CREB regulated transcription coactivator 3 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008140,GO:0016032,GO:0032793,GO:0042116,GO:0043951,GO:0045944,GO:0050995,GO:0051289,GO:0097009" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cAMP response element binding protein binding|viral process|positive regulation of CREB transcription factor activity|macrophage activation|negative regulation of cAMP-mediated signaling|positive regulation of transcription by RNA polymerase II|negative regulation of lipid catabolic process|protein homotetramerization|energy homeostasis hsa05166 Human T-cell leukemia virus 1 infection CRY1 1392.107528 1308.840664 1475.374392 1.127237587 0.172791623 0.471724305 1 24.66469658 27.33772796 1407 cryptochrome circadian regulator 1 "GO:0000122,GO:0003677,GO:0003690,GO:0003904,GO:0003914,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0006094,GO:0006975,GO:0007623,GO:0009416,GO:0009785,GO:0009882,GO:0014823,GO:0018298,GO:0019901,GO:0019902,GO:0019915,GO:0031397,GO:0031398,GO:0032868,GO:0032922,GO:0033762,GO:0035257,GO:0042593,GO:0042752,GO:0042754,GO:0042826,GO:0043153,GO:0045721,GO:0045744,GO:0045892,GO:0070888,GO:0071949,GO:2000001,GO:2000323,GO:2000850" "negative regulation of transcription by RNA polymerase II|DNA binding|double-stranded DNA binding|deoxyribodipyrimidine photo-lyase activity|DNA (6-4) photolyase activity|protein binding|nucleus|cytoplasm|mitochondrion|gluconeogenesis|DNA damage induced protein phosphorylation|circadian rhythm|response to light stimulus|blue light signaling pathway|blue light photoreceptor activity|response to activity|protein-chromophore linkage|protein kinase binding|phosphatase binding|lipid storage|negative regulation of protein ubiquitination|positive regulation of protein ubiquitination|response to insulin|circadian regulation of gene expression|response to glucagon|nuclear hormone receptor binding|glucose homeostasis|regulation of circadian rhythm|negative regulation of circadian rhythm|histone deacetylase binding|entrainment of circadian clock by photoperiod|negative regulation of gluconeogenesis|negative regulation of G protein-coupled receptor signaling pathway|negative regulation of transcription, DNA-templated|E-box binding|FAD binding|regulation of DNA damage checkpoint|negative regulation of glucocorticoid receptor signaling pathway|negative regulation of glucocorticoid secretion" hsa04710 Circadian rhythm other CRY2 362.4181189 342.2961674 382.5400705 1.117570417 0.160365737 0.594746279 1 4.253252 4.673768428 1408 cryptochrome circadian regulator 2 "GO:0000122,GO:0000719,GO:0000976,GO:0003677,GO:0003684,GO:0003697,GO:0003904,GO:0003914,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0007623,GO:0009416,GO:0009785,GO:0009882,GO:0014823,GO:0016607,GO:0018298,GO:0019902,GO:0032515,GO:0032922,GO:0042593,GO:0042752,GO:0042754,GO:0043153,GO:0045892,GO:0071949,GO:2000118,GO:2000323" "negative regulation of transcription by RNA polymerase II|photoreactive repair|transcription regulatory region sequence-specific DNA binding|DNA binding|damaged DNA binding|single-stranded DNA binding|deoxyribodipyrimidine photo-lyase activity|DNA (6-4) photolyase activity|protein binding|extracellular region|nucleus|cytoplasm|cytosol|circadian rhythm|response to light stimulus|blue light signaling pathway|blue light photoreceptor activity|response to activity|nuclear speck|protein-chromophore linkage|phosphatase binding|negative regulation of phosphoprotein phosphatase activity|circadian regulation of gene expression|glucose homeostasis|regulation of circadian rhythm|negative regulation of circadian rhythm|entrainment of circadian clock by photoperiod|negative regulation of transcription, DNA-templated|FAD binding|regulation of sodium-dependent phosphate transport|negative regulation of glucocorticoid receptor signaling pathway" hsa04710 Circadian rhythm CRYAB 5.965080553 5.202069413 6.728091692 1.29334908 0.371111717 0.919461532 1 0.240159934 0.305412981 1410 crystallin alpha B "GO:0001540,GO:0001666,GO:0002088,GO:0005198,GO:0005212,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005794,GO:0005829,GO:0006457,GO:0006936,GO:0007021,GO:0007517,GO:0008017,GO:0009986,GO:0010259,GO:0010941,GO:0014069,GO:0015630,GO:0030018,GO:0030308,GO:0030424,GO:0031109,GO:0031333,GO:0031430,GO:0032355,GO:0032387,GO:0032432,GO:0032991,GO:0042542,GO:0042802,GO:0042803,GO:0043066,GO:0043154,GO:0043197,GO:0043204,GO:0044877,GO:0045892,GO:0046872,GO:0050821,GO:0051082,GO:0051403,GO:0060561,GO:0070062,GO:0071480,GO:0097060,GO:0097512,GO:1900034,GO:1905907,GO:2000378" "amyloid-beta binding|response to hypoxia|lens development in camera-type eye|structural molecule activity|structural constituent of eye lens|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|Golgi apparatus|cytosol|protein folding|muscle contraction|tubulin complex assembly|muscle organ development|microtubule binding|cell surface|multicellular organism aging|regulation of cell death|postsynaptic density|microtubule cytoskeleton|Z disc|negative regulation of cell growth|axon|microtubule polymerization or depolymerization|negative regulation of protein-containing complex assembly|M band|response to estradiol|negative regulation of intracellular transport|actin filament bundle|protein-containing complex|response to hydrogen peroxide|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|dendritic spine|perikaryon|protein-containing complex binding|negative regulation of transcription, DNA-templated|metal ion binding|protein stabilization|unfolded protein binding|stress-activated MAPK cascade|apoptotic process involved in morphogenesis|extracellular exosome|cellular response to gamma radiation|synaptic membrane|cardiac myofibril|regulation of cellular response to heat|negative regulation of amyloid fibril formation|negative regulation of reactive oxygen species metabolic process" "hsa04141,hsa04213" Protein processing in endoplasmic reticulum|Longevity regulating pathway - multiple species CRYBG1 128.774162 150.860013 106.6883111 0.707200729 -0.499808334 0.244444873 1 0.801984423 0.557673248 202 crystallin beta-gamma domain containing 1 "GO:0003674,GO:0005575,GO:0008150,GO:0030246" molecular_function|cellular_component|biological_process|carbohydrate binding CRYBG2 31.10359043 34.33365813 27.87352272 0.811842496 -0.300728234 0.705387958 1 0.329317799 0.262880374 55057 crystallin beta-gamma domain containing 2 GO:0030246 carbohydrate binding CRYBG3 1003.44006 1110.121613 896.7585069 0.807802043 -0.3079263 0.210220936 1 5.496349398 4.365665517 131544 crystallin beta-gamma domain containing 3 "GO:0002088,GO:0005212,GO:0007601,GO:0008150,GO:0030246,GO:0032991,GO:0051018" lens development in camera-type eye|structural constituent of eye lens|visual perception|biological_process|carbohydrate binding|protein-containing complex|protein kinase A binding CRYGS 31.5841684 34.33365813 28.83467868 0.839837065 -0.251818634 0.757914683 1 2.171000274 1.792776269 1427 crystallin gamma S "GO:0002009,GO:0002088,GO:0005212,GO:0005515,GO:0007601" morphogenesis of an epithelium|lens development in camera-type eye|structural constituent of eye lens|protein binding|visual perception CRYL1 705.4350956 629.450399 781.4197922 1.24143188 0.3120051 0.223102749 1 14.89034172 18.1760177 51084 crystallin lambda 1 "GO:0003857,GO:0005829,GO:0006631,GO:0016616,GO:0019640,GO:0042803,GO:0050104,GO:0055114,GO:0070062,GO:0070403" "3-hydroxyacyl-CoA dehydrogenase activity|cytosol|fatty acid metabolic process|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|glucuronate catabolic process to xylulose 5-phosphate|protein homodimerization activity|L-gulonate 3-dehydrogenase activity|oxidation-reduction process|extracellular exosome|NAD+ binding" hsa00040 Pentose and glucuronate interconversions CRYM 6.044338479 7.282897178 4.80577978 0.65987198 -0.599741937 0.771875613 1 0.270664928 0.175615503 1428 crystallin mu "GO:0000122,GO:0003714,GO:0005515,GO:0005737,GO:0005782,GO:0005829,GO:0006554,GO:0007605,GO:0042403,GO:0042562,GO:0042803,GO:0047127,GO:0050661,GO:0055114,GO:0070062,GO:0070324,GO:0070327" negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|cytoplasm|peroxisomal matrix|cytosol|lysine catabolic process|sensory perception of sound|thyroid hormone metabolic process|hormone binding|protein homodimerization activity|thiomorpholine-carboxylate dehydrogenase activity|NADP binding|oxidation-reduction process|extracellular exosome|thyroid hormone binding|thyroid hormone transport CRYZ 417.1492882 378.7106533 455.5879231 1.202997379 0.266633499 0.352799131 1 9.740285072 11.52146029 1429 crystallin zeta "GO:0003730,GO:0003960,GO:0005829,GO:0007601,GO:0008270,GO:0042178,GO:0042802,GO:0051289,GO:0055114,GO:0070062,GO:0070402,GO:0070404" mRNA 3'-UTR binding|NADPH:quinone reductase activity|cytosol|visual perception|zinc ion binding|xenobiotic catabolic process|identical protein binding|protein homotetramerization|oxidation-reduction process|extracellular exosome|NADPH binding|NADH binding CRYZL1 557.1107219 495.2370081 618.9844357 1.249875162 0.321784005 0.228361084 1 16.53935477 20.32620864 9946 crystallin zeta like 1 "GO:0003960,GO:0005829,GO:0050661,GO:0055114,GO:1901661" NADPH:quinone reductase activity|cytosol|NADP binding|oxidation-reduction process|quinone metabolic process CRYZL2P-SEC16B 58.40218599 69.70773014 47.09664184 0.675630117 -0.565694456 0.322195583 1 0.705781339 0.468867738 111240474 CRYZL2P-SEC16B readthrough "GO:0000139,GO:0005515,GO:0005789,GO:0005829,GO:0006888,GO:0006914,GO:0007029,GO:0007030,GO:0007031,GO:0010628,GO:0012507,GO:0015031,GO:0016559,GO:0043231,GO:0048208,GO:0070863,GO:0070971,GO:0070973" Golgi membrane|protein binding|endoplasmic reticulum membrane|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|autophagy|endoplasmic reticulum organization|Golgi organization|peroxisome organization|positive regulation of gene expression|ER to Golgi transport vesicle membrane|protein transport|peroxisome fission|intracellular membrane-bounded organelle|COPII vesicle coating|positive regulation of protein exit from endoplasmic reticulum|endoplasmic reticulum exit site|protein localization to endoplasmic reticulum exit site CS 6212.60728 6123.876113 6301.338447 1.02897876 0.041213202 0.865698118 1 112.1166425 113.435156 1431 citrate synthase "GO:0003723,GO:0004108,GO:0005634,GO:0005739,GO:0005759,GO:0005975,GO:0006099,GO:0006101,GO:0070062" RNA binding|citrate (Si)-synthase activity|nucleus|mitochondrion|mitochondrial matrix|carbohydrate metabolic process|tricarboxylic acid cycle|citrate metabolic process|extracellular exosome "hsa00020,hsa00630" Citrate cycle (TCA cycle)|Glyoxylate and dicarboxylate metabolism CSAD 217.5320186 222.6485709 212.4154663 0.954039208 -0.067879537 0.859574498 1 2.74609314 2.576040373 51380 cysteine sulfinic acid decarboxylase "GO:0004068,GO:0004782,GO:0005737,GO:0019449,GO:0019452,GO:0030170,GO:0042412" aspartate 1-decarboxylase activity|sulfinoalanine decarboxylase activity|cytoplasm|L-cysteine catabolic process to hypotaurine|L-cysteine catabolic process to taurine|pyridoxal phosphate binding|taurine biosynthetic process hsa00430 Taurine and hypotaurine metabolism CSAG1 514.809799 520.2069413 509.4126567 0.979250018 -0.030250845 0.918711144 1 32.24446964 31.04702596 158511 chondrosarcoma associated gene 1 CSAG2 11.20677893 16.64662212 5.766935736 0.346432789 -1.529352609 0.169178138 1 0.913052032 0.311018124 102723547 "GO:0005515,GO:0042493" protein binding|response to drug CSAG3 125.5837233 117.5667687 133.6006779 1.136381303 0.184447 0.682149825 1 3.283266546 3.668608769 389903 CSAG family member 3 "GO:0005515,GO:0042493" protein binding|response to drug CSDE1 12121.51505 12084.40725 12158.62284 1.006141435 0.008833121 0.972842393 1 151.9610284 150.3358083 7812 cold shock domain containing E1 "GO:0000932,GO:0003723,GO:0005515,GO:0005794,GO:0005829,GO:0005886,GO:0006446,GO:0008584,GO:0010494,GO:0034063,GO:0035613,GO:0070937,GO:0070966,GO:0075522" "P-body|RNA binding|protein binding|Golgi apparatus|cytosol|plasma membrane|regulation of translational initiation|male gonad development|cytoplasmic stress granule|stress granule assembly|RNA stem-loop binding|CRD-mediated mRNA stability complex|nuclear-transcribed mRNA catabolic process, no-go decay|IRES-dependent viral translational initiation" CSE1L 7752.054718 7326.594562 8177.514874 1.116141313 0.158519696 0.519636027 1 105.0246806 115.2608271 1434 chromosome segregation 1 like "GO:0005049,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005829,GO:0006606,GO:0006611,GO:0016020,GO:0070062" nuclear export signal receptor activity|protein binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|cytosol|protein import into nucleus|protein export from nucleus|membrane|extracellular exosome hsa05132 Salmonella infection CSF1 749.3143035 961.3424276 537.2861794 0.558891571 -0.839359678 0.000980937 0.194410378 11.51629147 6.328654489 1435 colony stimulating factor 1 "GO:0001954,GO:0002158,GO:0002931,GO:0003006,GO:0005125,GO:0005157,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005886,GO:0006954,GO:0007169,GO:0008083,GO:0008284,GO:0010628,GO:0010743,GO:0010744,GO:0010759,GO:0016020,GO:0016021,GO:0016604,GO:0019221,GO:0030225,GO:0030278,GO:0030316,GO:0030335,GO:0032270,GO:0032946,GO:0038145,GO:0040018,GO:0042117,GO:0042488,GO:0042802,GO:0042803,GO:0043687,GO:0044267,GO:0045087,GO:0045651,GO:0045657,GO:0045672,GO:0045860,GO:0046579,GO:0048471,GO:0048873,GO:0060444,GO:0060611,GO:0060763,GO:0061518,GO:1901215,GO:1902228,GO:1904141,GO:1990682" positive regulation of cell-matrix adhesion|osteoclast proliferation|response to ischemia|developmental process involved in reproduction|cytokine activity|macrophage colony-stimulating factor receptor binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|plasma membrane|inflammatory response|transmembrane receptor protein tyrosine kinase signaling pathway|growth factor activity|positive regulation of cell population proliferation|positive regulation of gene expression|regulation of macrophage derived foam cell differentiation|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage chemotaxis|membrane|integral component of membrane|nuclear body|cytokine-mediated signaling pathway|macrophage differentiation|regulation of ossification|osteoclast differentiation|positive regulation of cell migration|positive regulation of cellular protein metabolic process|positive regulation of mononuclear cell proliferation|macrophage colony-stimulating factor signaling pathway|positive regulation of multicellular organism growth|monocyte activation|positive regulation of odontogenesis of dentin-containing tooth|identical protein binding|protein homodimerization activity|post-translational protein modification|cellular protein metabolic process|innate immune response|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of osteoclast differentiation|positive regulation of protein kinase activity|positive regulation of Ras protein signal transduction|perinuclear region of cytoplasm|homeostasis of number of cells within a tissue|branching involved in mammary gland duct morphogenesis|mammary gland fat development|mammary duct terminal end bud growth|microglial cell proliferation|negative regulation of neuron death|positive regulation of macrophage colony-stimulating factor signaling pathway|positive regulation of microglial cell migration|CSF1-CSF1R complex "hsa04010,hsa04014,hsa04015,hsa04060,hsa04061,hsa04151,hsa04380,hsa04640,hsa04668,hsa05010,hsa05022,hsa05323" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|PI3K-Akt signaling pathway|Osteoclast differentiation|Hematopoietic cell lineage|TNF signaling pathway|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Rheumatoid arthritis CSF1R 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.036761496 1436 colony stimulating factor 1 receptor "GO:0001934,GO:0002244,GO:0002931,GO:0004713,GO:0004714,GO:0005011,GO:0005515,GO:0005524,GO:0005654,GO:0005886,GO:0005887,GO:0006954,GO:0007165,GO:0007169,GO:0007275,GO:0007411,GO:0008283,GO:0008284,GO:0008285,GO:0008360,GO:0009986,GO:0010759,GO:0018108,GO:0019221,GO:0019903,GO:0019955,GO:0021772,GO:0021879,GO:0030097,GO:0030224,GO:0030225,GO:0030316,GO:0030335,GO:0031529,GO:0032722,GO:0033674,GO:0036006,GO:0038145,GO:0042531,GO:0042803,GO:0043066,GO:0043231,GO:0043235,GO:0044794,GO:0045087,GO:0045124,GO:0045217,GO:0046488,GO:0046777,GO:0048015,GO:0060603,GO:0061098,GO:0061518,GO:0070374,GO:0071345,GO:0071902,GO:0120041,GO:1990682,GO:2000147,GO:2000249" positive regulation of protein phosphorylation|hematopoietic progenitor cell differentiation|response to ischemia|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|macrophage colony-stimulating factor receptor activity|protein binding|ATP binding|nucleoplasm|plasma membrane|integral component of plasma membrane|inflammatory response|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|cell population proliferation|positive regulation of cell population proliferation|negative regulation of cell population proliferation|regulation of cell shape|cell surface|positive regulation of macrophage chemotaxis|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|protein phosphatase binding|cytokine binding|olfactory bulb development|forebrain neuron differentiation|hemopoiesis|monocyte differentiation|macrophage differentiation|osteoclast differentiation|positive regulation of cell migration|ruffle organization|positive regulation of chemokine production|positive regulation of kinase activity|cellular response to macrophage colony-stimulating factor stimulus|macrophage colony-stimulating factor signaling pathway|positive regulation of tyrosine phosphorylation of STAT protein|protein homodimerization activity|negative regulation of apoptotic process|intracellular membrane-bounded organelle|receptor complex|positive regulation by host of viral process|innate immune response|regulation of bone resorption|cell-cell junction maintenance|phosphatidylinositol metabolic process|protein autophosphorylation|phosphatidylinositol-mediated signaling|mammary gland duct morphogenesis|positive regulation of protein tyrosine kinase activity|microglial cell proliferation|positive regulation of ERK1 and ERK2 cascade|cellular response to cytokine stimulus|positive regulation of protein serine/threonine kinase activity|positive regulation of macrophage proliferation|CSF1-CSF1R complex|positive regulation of cell motility|regulation of actin cytoskeleton reorganization "hsa04010,hsa04014,hsa04015,hsa04060,hsa04061,hsa04151,hsa04380,hsa04640,hsa05200,hsa05202,hsa05221" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|PI3K-Akt signaling pathway|Osteoclast differentiation|Hematopoietic cell lineage|Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia CSF2 4078.161989 3734.045425 4422.278554 1.184313004 0.244050423 0.305817154 1 252.8923115 294.491865 1437 colony stimulating factor 2 "GO:0000165,GO:0001821,GO:0001892,GO:0005125,GO:0005129,GO:0005515,GO:0005576,GO:0005615,GO:0006955,GO:0008083,GO:0008284,GO:0010628,GO:0010744,GO:0019221,GO:0030099,GO:0030223,GO:0030224,GO:0030225,GO:0032747,GO:0034021,GO:0034405,GO:0042045,GO:0042116,GO:0042531,GO:0043011,GO:0043231,GO:0045187,GO:0045637,GO:0045892,GO:0071222,GO:0071803,GO:0097011,GO:0097028,GO:2001240" "MAPK cascade|histamine secretion|embryonic placenta development|cytokine activity|granulocyte macrophage colony-stimulating factor receptor binding|protein binding|extracellular region|extracellular space|immune response|growth factor activity|positive regulation of cell population proliferation|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|cytokine-mediated signaling pathway|myeloid cell differentiation|neutrophil differentiation|monocyte differentiation|macrophage differentiation|positive regulation of interleukin-23 production|response to silicon dioxide|response to fluid shear stress|epithelial fluid transport|macrophage activation|positive regulation of tyrosine phosphorylation of STAT protein|myeloid dendritic cell differentiation|intracellular membrane-bounded organelle|regulation of circadian sleep/wake cycle, sleep|regulation of myeloid cell differentiation|negative regulation of transcription, DNA-templated|cellular response to lipopolysaccharide|positive regulation of podosome assembly|cellular response to granulocyte macrophage colony-stimulating factor stimulus|dendritic cell differentiation|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa04060,hsa04630,hsa04640,hsa04650,hsa04657,hsa04660,hsa04664,hsa04668,hsa05131,hsa05146,hsa05166,hsa05167,hsa05171,hsa05202,hsa05221,hsa05323" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway|Hematopoietic cell lineage|Natural killer cell mediated cytotoxicity|IL-17 signaling pathway|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Shigellosis|Amoebiasis|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Coronavirus disease - COVID-19|Transcriptional misregulation in cancer|Acute myeloid leukemia|Rheumatoid arthritis CSF3 18720.04449 16871.35152 20568.73746 1.219151734 0.285877693 0.29085094 1 598.6655734 717.6508833 1440 colony stimulating factor 3 "GO:0005125,GO:0005130,GO:0005576,GO:0005615,GO:0006955,GO:0007275,GO:0008083,GO:0008284,GO:0014068,GO:0019221,GO:0019899,GO:0030838,GO:0030851,GO:0032092,GO:0033138,GO:0045471,GO:0045639,GO:0045944,GO:0050731,GO:0051091,GO:0051897,GO:0071222,GO:0071345,GO:1901215,GO:2000251" cytokine activity|granulocyte colony-stimulating factor receptor binding|extracellular region|extracellular space|immune response|multicellular organism development|growth factor activity|positive regulation of cell population proliferation|positive regulation of phosphatidylinositol 3-kinase signaling|cytokine-mediated signaling pathway|enzyme binding|positive regulation of actin filament polymerization|granulocyte differentiation|positive regulation of protein binding|positive regulation of peptidyl-serine phosphorylation|response to ethanol|positive regulation of myeloid cell differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of DNA-binding transcription factor activity|positive regulation of protein kinase B signaling|cellular response to lipopolysaccharide|cellular response to cytokine stimulus|negative regulation of neuron death|positive regulation of actin cytoskeleton reorganization "hsa04060,hsa04151,hsa04630,hsa04640,hsa04657,hsa05144,hsa05171" Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|JAK-STAT signaling pathway|Hematopoietic cell lineage|IL-17 signaling pathway|Malaria|Coronavirus disease - COVID-19 CSGALNACT2 1176.185206 1166.303962 1186.06645 1.016944543 0.024241006 0.924033152 1 15.61944765 15.61831295 55454 chondroitin sulfate N-acetylgalactosaminyltransferase 2 "GO:0000139,GO:0005515,GO:0008376,GO:0016020,GO:0030166,GO:0030173,GO:0030206,GO:0032580,GO:0046872,GO:0047237,GO:0047238,GO:0050650,GO:0050651,GO:0050652,GO:0050653" "Golgi membrane|protein binding|acetylgalactosaminyltransferase activity|membrane|proteoglycan biosynthetic process|integral component of Golgi membrane|chondroitin sulfate biosynthetic process|Golgi cisterna membrane|metal ion binding|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|chondroitin sulfate proteoglycan biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process" hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CSK 992.5163285 987.3527746 997.6798823 1.01045939 0.015011341 0.955817032 1 19.5087756 19.38295806 1445 C-terminal Src kinase "GO:0002250,GO:0004713,GO:0004715,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0006468,GO:0007420,GO:0008022,GO:0008285,GO:0010989,GO:0018108,GO:0019903,GO:0031295,GO:0032715,GO:0033673,GO:0034236,GO:0034332,GO:0042802,GO:0042997,GO:0043406,GO:0045121,GO:0045779,GO:0046777,GO:0046872,GO:0048709,GO:0050765,GO:0050852,GO:0060368,GO:0070062,GO:0070064,GO:0070373,GO:0071375" adaptive immune response|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|cell-cell junction|protein phosphorylation|brain development|protein C-terminus binding|negative regulation of cell population proliferation|negative regulation of low-density lipoprotein particle clearance|peptidyl-tyrosine phosphorylation|protein phosphatase binding|T cell costimulation|negative regulation of interleukin-6 production|negative regulation of kinase activity|protein kinase A catalytic subunit binding|adherens junction organization|identical protein binding|negative regulation of Golgi to plasma membrane protein transport|positive regulation of MAP kinase activity|membrane raft|negative regulation of bone resorption|protein autophosphorylation|metal ion binding|oligodendrocyte differentiation|negative regulation of phagocytosis|T cell receptor signaling pathway|regulation of Fc receptor mediated stimulatory signaling pathway|extracellular exosome|proline-rich region binding|negative regulation of ERK1 and ERK2 cascade|cellular response to peptide hormone stimulus hsa05120 Epithelial cell signaling in Helicobacter pylori infection CSKMT 81.66807375 74.90979955 88.42634795 1.180437653 0.239321845 0.649197625 1 1.660904995 1.927786895 751071 citrate synthase lysine methyltransferase "GO:0005515,GO:0005739,GO:0006479,GO:0016278,GO:0016279,GO:0018023,GO:0018026,GO:0018027" protein binding|mitochondrion|protein methylation|lysine N-methyltransferase activity|protein-lysine N-methyltransferase activity|peptidyl-lysine trimethylation|peptidyl-lysine monomethylation|peptidyl-lysine dimethylation CSMD3 111.7708793 108.2030438 115.3387147 1.065947044 0.092135768 0.856735002 1 0.406776386 0.426346343 114788 CUB and Sushi multiple domains 3 "GO:0005886,GO:0016021,GO:0050773" plasma membrane|integral component of membrane|regulation of dendrite development CSNK1A1 5766.312541 5522.516889 6010.108193 1.088291501 0.122065037 0.613740013 1 52.36790626 56.03787093 1452 casein kinase 1 alpha 1 "GO:0000777,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0005847,GO:0005929,GO:0006468,GO:0007030,GO:0007049,GO:0007165,GO:0007166,GO:0016020,GO:0016055,GO:0016301,GO:0016607,GO:0018105,GO:0030877,GO:0032436,GO:0036064,GO:0045095,GO:0045104,GO:0051301,GO:0090090,GO:0106310,GO:0106311,GO:1904424,GO:1904885,GO:1904886" condensed chromosome kinetochore|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|centrosome|cytosol|mRNA cleavage and polyadenylation specificity factor complex|cilium|protein phosphorylation|Golgi organization|cell cycle|signal transduction|cell surface receptor signaling pathway|membrane|Wnt signaling pathway|kinase activity|nuclear speck|peptidyl-serine phosphorylation|beta-catenin destruction complex|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|ciliary basal body|keratin filament|intermediate filament cytoskeleton organization|cell division|negative regulation of canonical Wnt signaling pathway|protein serine kinase activity|protein threonine kinase activity|regulation of GTP binding|beta-catenin destruction complex assembly|beta-catenin destruction complex disassembly "hsa04310,hsa04340,hsa05010,hsa05022,hsa05165,hsa05224,hsa05225,hsa05226" Wnt signaling pathway|Hedgehog signaling pathway|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Breast cancer|Hepatocellular carcinoma|Gastric cancer CSNK1D 4286.963117 4156.453461 4417.472774 1.062798565 0.087868185 0.713309284 1 32.91620151 34.39789372 1453 casein kinase 1 delta "GO:0000086,GO:0000139,GO:0001934,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005813,GO:0005819,GO:0005829,GO:0005876,GO:0005886,GO:0006468,GO:0007020,GO:0007030,GO:0010389,GO:0016055,GO:0018105,GO:0032436,GO:0032922,GO:0033116,GO:0034067,GO:0036064,GO:0042752,GO:0045296,GO:0048208,GO:0048471,GO:0050321,GO:0051225,GO:0061512,GO:0071539,GO:0090263,GO:0097711,GO:0106310,GO:0106311,GO:1905426,GO:1905515,GO:2000052" G2/M transition of mitotic cell cycle|Golgi membrane|positive regulation of protein phosphorylation|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|centrosome|spindle|cytosol|spindle microtubule|plasma membrane|protein phosphorylation|microtubule nucleation|Golgi organization|regulation of G2/M transition of mitotic cell cycle|Wnt signaling pathway|peptidyl-serine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|circadian regulation of gene expression|endoplasmic reticulum-Golgi intermediate compartment membrane|protein localization to Golgi apparatus|ciliary basal body|regulation of circadian rhythm|cadherin binding|COPII vesicle coating|perinuclear region of cytoplasm|tau-protein kinase activity|spindle assembly|protein localization to cilium|protein localization to centrosome|positive regulation of canonical Wnt signaling pathway|ciliary basal body-plasma membrane docking|protein serine kinase activity|protein threonine kinase activity|positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation|non-motile cilium assembly|positive regulation of non-canonical Wnt signaling pathway "hsa04340,hsa04390,hsa04540,hsa04710" Hedgehog signaling pathway|Hippo signaling pathway|Gap junction|Circadian rhythm CSNK1G1 214.4850044 230.9718819 197.9981269 0.857239094 -0.222230449 0.535952443 1 5.38042114 4.535126629 53944 casein kinase 1 gamma 1 "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006897,GO:0016055,GO:0018105,GO:0090263,GO:0106310,GO:0106311" protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|endocytosis|Wnt signaling pathway|peptidyl-serine phosphorylation|positive regulation of canonical Wnt signaling pathway|protein serine kinase activity|protein threonine kinase activity hsa04340 Hedgehog signaling pathway CSNK1G2 1594.171119 1655.298487 1533.04375 0.926143388 -0.110692522 0.643323074 1 21.31248202 19.40811868 1455 casein kinase 1 gamma 2 "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005938,GO:0006468,GO:0006897,GO:0007165,GO:0016020,GO:0016055,GO:0018105,GO:0030148,GO:0046777,GO:0090263,GO:0106310,GO:0106311" protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|cell cortex|protein phosphorylation|endocytosis|signal transduction|membrane|Wnt signaling pathway|peptidyl-serine phosphorylation|sphingolipid biosynthetic process|protein autophosphorylation|positive regulation of canonical Wnt signaling pathway|protein serine kinase activity|protein threonine kinase activity hsa04340 Hedgehog signaling pathway CSNK1G3 1428.546552 1420.16495 1436.928154 1.011803702 0.016929423 0.946734397 1 14.99635798 14.91946472 1456 casein kinase 1 gamma 3 "GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0005886,GO:0006464,GO:0006897,GO:0007165,GO:0016055,GO:0018105,GO:0090263,GO:0106310,GO:0106311" protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|plasma membrane|cellular protein modification process|endocytosis|signal transduction|Wnt signaling pathway|peptidyl-serine phosphorylation|positive regulation of canonical Wnt signaling pathway|protein serine kinase activity|protein threonine kinase activity hsa04340 Hedgehog signaling pathway CSNK2A1 5816.812243 5624.47745 6009.147037 1.068392058 0.095441157 0.693378397 1 23.1183013 24.28609834 1457 casein kinase 2 alpha 1 "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0005956,GO:0006457,GO:0006468,GO:0006656,GO:0006915,GO:0007049,GO:0007165,GO:0008284,GO:0016055,GO:0016236,GO:0016301,GO:0016580,GO:0016581,GO:0018105,GO:0018107,GO:0030177,GO:0030307,GO:0031519,GO:0042802,GO:0043154,GO:0045732,GO:0047485,GO:0048511,GO:0051726,GO:0051879,GO:0061077,GO:0106310,GO:0106311,GO:1901796,GO:1905818,GO:2000059,GO:2001234" protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|protein kinase CK2 complex|protein folding|protein phosphorylation|phosphatidylcholine biosynthetic process|apoptotic process|cell cycle|signal transduction|positive regulation of cell population proliferation|Wnt signaling pathway|macroautophagy|kinase activity|Sin3 complex|NuRD complex|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of Wnt signaling pathway|positive regulation of cell growth|PcG protein complex|identical protein binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of protein catabolic process|protein N-terminus binding|rhythmic process|regulation of cell cycle|Hsp90 protein binding|chaperone-mediated protein folding|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator|regulation of chromosome separation|negative regulation of ubiquitin-dependent protein catabolic process|negative regulation of apoptotic signaling pathway "hsa03008,hsa04064,hsa04137,hsa04310,hsa04520,hsa05010,hsa05020,hsa05022,hsa05162,hsa05235" Ribosome biogenesis in eukaryotes|NF-kappa B signaling pathway|Mitophagy - animal|Wnt signaling pathway|Adherens junction|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Measles|PD-L1 expression and PD-1 checkpoint pathway in cancer CSNK2A2 1294.699268 1237.052106 1352.34643 1.093200863 0.128558504 0.594926131 1 26.71760312 28.71895537 1459 casein kinase 2 alpha 2 "GO:0000785,GO:0001669,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0005956,GO:0006457,GO:0006656,GO:0006915,GO:0007049,GO:0007283,GO:0016055,GO:0016236,GO:0018105,GO:0018107,GO:0021987,GO:0031519,GO:0047485,GO:0051726,GO:0097421,GO:0106310,GO:0106311,GO:1901796,GO:1903146,GO:1903955,GO:1905818,GO:2000059,GO:2001234" chromatin|acrosomal vesicle|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|protein kinase CK2 complex|protein folding|phosphatidylcholine biosynthetic process|apoptotic process|cell cycle|spermatogenesis|Wnt signaling pathway|macroautophagy|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|cerebral cortex development|PcG protein complex|protein N-terminus binding|regulation of cell cycle|liver regeneration|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion|regulation of chromosome separation|negative regulation of ubiquitin-dependent protein catabolic process|negative regulation of apoptotic signaling pathway "hsa03008,hsa04064,hsa04137,hsa04310,hsa04520,hsa05010,hsa05020,hsa05022,hsa05162,hsa05235" Ribosome biogenesis in eukaryotes|NF-kappa B signaling pathway|Mitophagy - animal|Wnt signaling pathway|Adherens junction|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Measles|PD-L1 expression and PD-1 checkpoint pathway in cancer CSNK2A3 296.0341913 302.7604398 289.3079428 0.95556719 -0.065570776 0.845546143 1 12.34359681 11.59776049 283106 casein kinase 2 alpha 3 "hsa03008,hsa04064,hsa04137,hsa04310,hsa04520,hsa05010,hsa05020,hsa05022,hsa05162,hsa05235" Ribosome biogenesis in eukaryotes|NF-kappa B signaling pathway|Mitophagy - animal|Wnt signaling pathway|Adherens junction|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Measles|PD-L1 expression and PD-1 checkpoint pathway in cancer CSNK2B 2329.313959 2105.797698 2552.830219 1.212286546 0.277730747 0.24008915 1 120.9715316 144.198135 1460 casein kinase 2 beta "GO:0003682,GO:0004674,GO:0005102,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005956,GO:0006457,GO:0006656,GO:0007165,GO:0008134,GO:0008285,GO:0010862,GO:0016055,GO:0016236,GO:0018107,GO:0019887,GO:0019904,GO:0031519,GO:0032927,GO:0033211,GO:0034622,GO:0034774,GO:0042802,GO:0043312,GO:0043537,GO:0045859,GO:0046872,GO:0051101,GO:0061154,GO:0070062,GO:1901796,GO:1904813" chromatin binding|protein serine/threonine kinase activity|signaling receptor binding|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|protein kinase CK2 complex|protein folding|phosphatidylcholine biosynthetic process|signal transduction|transcription factor binding|negative regulation of cell population proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|Wnt signaling pathway|macroautophagy|peptidyl-threonine phosphorylation|protein kinase regulator activity|protein domain specific binding|PcG protein complex|positive regulation of activin receptor signaling pathway|adiponectin-activated signaling pathway|cellular protein-containing complex assembly|secretory granule lumen|identical protein binding|neutrophil degranulation|negative regulation of blood vessel endothelial cell migration|regulation of protein kinase activity|metal ion binding|regulation of DNA binding|endothelial tube morphogenesis|extracellular exosome|regulation of signal transduction by p53 class mediator|ficolin-1-rich granule lumen "hsa03008,hsa04064,hsa04137,hsa04310,hsa04520,hsa05010,hsa05020,hsa05022,hsa05162,hsa05235" Ribosome biogenesis in eukaryotes|NF-kappa B signaling pathway|Mitophagy - animal|Wnt signaling pathway|Adherens junction|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Measles|PD-L1 expression and PD-1 checkpoint pathway in cancer CSPG4 344.0718674 352.7003062 335.4434286 0.951072122 -0.072373347 0.819092129 1 2.27056298 2.12333336 1464 chondroitin sulfate proteoglycan 4 "GO:0000187,GO:0001525,GO:0001726,GO:0005576,GO:0005654,GO:0005796,GO:0005886,GO:0005887,GO:0005925,GO:0006929,GO:0008283,GO:0008347,GO:0009986,GO:0015026,GO:0016324,GO:0019901,GO:0030206,GO:0030207,GO:0030208,GO:0031258,GO:0035556,GO:0043202,GO:0048008,GO:0048771,GO:0050731,GO:0062023,GO:0070062,GO:0097178" activation of MAPK activity|angiogenesis|ruffle|extracellular region|nucleoplasm|Golgi lumen|plasma membrane|integral component of plasma membrane|focal adhesion|substrate-dependent cell migration|cell population proliferation|glial cell migration|cell surface|coreceptor activity|apical plasma membrane|protein kinase binding|chondroitin sulfate biosynthetic process|chondroitin sulfate catabolic process|dermatan sulfate biosynthetic process|lamellipodium membrane|intracellular signal transduction|lysosomal lumen|platelet-derived growth factor receptor signaling pathway|tissue remodeling|positive regulation of peptidyl-tyrosine phosphorylation|collagen-containing extracellular matrix|extracellular exosome|ruffle assembly CSPG5 45.47627038 45.77821084 45.17432993 0.986808552 -0.019157877 1 1 0.944740516 0.916677611 10675 chondroitin sulfate proteoglycan 5 "GO:0000139,GO:0005515,GO:0005576,GO:0005789,GO:0005794,GO:0005796,GO:0005887,GO:0007010,GO:0007165,GO:0007399,GO:0008083,GO:0009986,GO:0016020,GO:0016021,GO:0030206,GO:0030207,GO:0030208,GO:0030660,GO:0040008,GO:0043202,GO:0045202,GO:0046907,GO:0048858,GO:0098978,GO:0098982,GO:0099055,GO:0099550,GO:0106091,GO:1900026,GO:2000300" "Golgi membrane|protein binding|extracellular region|endoplasmic reticulum membrane|Golgi apparatus|Golgi lumen|integral component of plasma membrane|cytoskeleton organization|signal transduction|nervous system development|growth factor activity|cell surface|membrane|integral component of membrane|chondroitin sulfate biosynthetic process|chondroitin sulfate catabolic process|dermatan sulfate biosynthetic process|Golgi-associated vesicle membrane|regulation of growth|lysosomal lumen|synapse|intracellular transport|cell projection morphogenesis|glutamatergic synapse|GABA-ergic synapse|integral component of postsynaptic membrane|trans-synaptic signaling, modulating synaptic transmission|glial cell projection elongation|positive regulation of substrate adhesion-dependent cell spreading|regulation of synaptic vesicle exocytosis" CSPP1 587.4506868 635.6928823 539.2084913 0.848221691 -0.237486719 0.369608548 1 4.545251979 3.790866733 79848 centrosome and spindle pole associated protein 1 "GO:0000922,GO:0005737,GO:0005813,GO:0005819,GO:0005874,GO:0032467,GO:0051781" spindle pole|cytoplasm|centrosome|spindle|microtubule|positive regulation of cytokinesis|positive regulation of cell division CSRNP1 409.5984347 432.8121752 386.3846943 0.89273065 -0.163703137 0.573102805 1 6.281857578 5.514164397 64651 cysteine and serine rich nuclear protein 1 "GO:0000785,GO:0000981,GO:0001228,GO:0003674,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0006915,GO:0009791,GO:0043565,GO:0045944,GO:0048008,GO:0048705,GO:0060021,GO:0060325" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|molecular_function|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|apoptotic process|post-embryonic development|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|platelet-derived growth factor receptor signaling pathway|skeletal system morphogenesis|roof of mouth development|face morphogenesis" CSRNP2 854.6753515 876.0284892 833.3222138 0.95125013 -0.07210335 0.77656556 1 8.152054123 7.6248791 81566 cysteine and serine rich nuclear protein 2 "GO:0000785,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0006915,GO:0010923,GO:0019902,GO:0043565,GO:0045944" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|apoptotic process|negative regulation of phosphatase activity|phosphatase binding|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II" CSRNP3 172.7395014 169.5874629 175.8915399 1.037173014 0.052656574 0.906545963 1 0.715234013 0.72940804 80034 cysteine and serine rich nuclear protein 3 "GO:0000785,GO:0000981,GO:0003700,GO:0005634,GO:0006357,GO:0006915,GO:0010923,GO:0043065,GO:0043565,GO:0045944" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|apoptotic process|negative regulation of phosphatase activity|positive regulation of apoptotic process|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II" CSRP1 4370.389957 4239.686572 4501.093342 1.061657098 0.086317869 0.718329066 1 103.4114626 107.9503679 1465 cysteine and glycine rich protein 1 "GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0005925,GO:0008270,GO:0008307,GO:0030018,GO:0030036,GO:0042805,GO:0045214,GO:0060537,GO:0070062,GO:0070527" RNA binding|protein binding|nucleus|cytoplasm|focal adhesion|zinc ion binding|structural constituent of muscle|Z disc|actin cytoskeleton organization|actinin binding|sarcomere organization|muscle tissue development|extracellular exosome|platelet aggregation CSRP2 748.3902036 571.1872216 925.5931856 1.620472501 0.696414539 0.006185046 0.469832129 33.57181962 53.4918632 1466 cysteine and glycine rich protein 2 "GO:0003674,GO:0005515,GO:0005634,GO:0005737,GO:0005925,GO:0007275,GO:0008307,GO:0030018,GO:0030036,GO:0030154,GO:0042805,GO:0045214,GO:0046872,GO:0060537" molecular_function|protein binding|nucleus|cytoplasm|focal adhesion|multicellular organism development|structural constituent of muscle|Z disc|actin cytoskeleton organization|cell differentiation|actinin binding|sarcomere organization|metal ion binding|muscle tissue development CST3 1742.357712 1634.49021 1850.225215 1.13198917 0.178860155 0.451633891 1 24.55100997 27.32642465 1471 cystatin C "GO:0001540,GO:0002020,GO:0004866,GO:0004869,GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0005788,GO:0005794,GO:0005886,GO:0006952,GO:0010466,GO:0010711,GO:0010716,GO:0010951,GO:0030414,GO:0034103,GO:0042802,GO:0043312,GO:0043687,GO:0044267,GO:0045861,GO:0060311,GO:0060313,GO:0070062,GO:0097435,GO:1904724,GO:1904813" amyloid-beta binding|protease binding|endopeptidase inhibitor activity|cysteine-type endopeptidase inhibitor activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|Golgi apparatus|plasma membrane|defense response|negative regulation of peptidase activity|negative regulation of collagen catabolic process|negative regulation of extracellular matrix disassembly|negative regulation of endopeptidase activity|peptidase inhibitor activity|regulation of tissue remodeling|identical protein binding|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|negative regulation of proteolysis|negative regulation of elastin catabolic process|negative regulation of blood vessel remodeling|extracellular exosome|supramolecular fiber organization|tertiary granule lumen|ficolin-1-rich granule lumen hsa04970 Salivary secretion CSTA 8.724631112 14.56579436 2.883467868 0.197961594 -2.336707531 0.072265798 1 1.044824831 0.203374082 1475 cystatin A "GO:0001533,GO:0002020,GO:0004869,GO:0005515,GO:0005615,GO:0005654,GO:0005737,GO:0005829,GO:0010466,GO:0010951,GO:0018149,GO:0030216,GO:0045861,GO:0070268,GO:0098609" cornified envelope|protease binding|cysteine-type endopeptidase inhibitor activity|protein binding|extracellular space|nucleoplasm|cytoplasm|cytosol|negative regulation of peptidase activity|negative regulation of endopeptidase activity|peptide cross-linking|keratinocyte differentiation|negative regulation of proteolysis|cornification|cell-cell adhesion CSTB 1642.358478 1532.529649 1752.187308 1.14333012 0.193242021 0.416886755 1 139.0957325 156.3711497 1476 cystatin B "GO:0002020,GO:0003723,GO:0004866,GO:0004869,GO:0005576,GO:0005615,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0008344,GO:0010466,GO:0010951,GO:0034774,GO:0043312,GO:0045861,GO:0062023,GO:0070062,GO:1904724,GO:1904813" protease binding|RNA binding|endopeptidase inhibitor activity|cysteine-type endopeptidase inhibitor activity|extracellular region|extracellular space|nucleus|nucleolus|cytoplasm|cytosol|adult locomotory behavior|negative regulation of peptidase activity|negative regulation of endopeptidase activity|secretory granule lumen|neutrophil degranulation|negative regulation of proteolysis|collagen-containing extracellular matrix|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen CSTF1 1165.533233 1164.223135 1166.843331 1.002250596 0.003243275 0.993390572 1 14.42592267 14.21644803 1477 cleavage stimulation factor subunit 1 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005848,GO:0006369,GO:0031124" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|mRNA cleavage stimulating factor complex|termination of RNA polymerase II transcription|mRNA 3'-end processing" hsa03015 mRNA surveillance pathway CSTF2 1062.481954 1083.070852 1041.893056 0.961980515 -0.055920422 0.822487258 1 21.97775694 20.7883883 1478 cleavage stimulation factor subunit 2 "GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0005847,GO:0006369,GO:0006378,GO:0006388,GO:0016604,GO:0031124,GO:0071920,GO:0098789" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|tRNA splicing, via endonucleolytic cleavage and ligation|nuclear body|mRNA 3'-end processing|cleavage body|pre-mRNA cleavage required for polyadenylation" hsa03015 mRNA surveillance pathway CSTF2T 1245.551367 1258.900798 1232.201936 0.978791925 -0.030925895 0.901400299 1 16.3467693 15.73234603 23283 cleavage stimulation factor subunit 2 tau variant "GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0005847,GO:0006369,GO:0031124,GO:0043231,GO:0098789" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA 3'-end processing|intracellular membrane-bounded organelle|pre-mRNA cleavage required for polyadenylation" hsa03015 mRNA surveillance pathway CSTF3 766.8044234 789.6741369 743.9347099 0.942078099 -0.086081429 0.737514445 1 13.29446603 12.314846 1479 cleavage stimulation factor subunit 3 "GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0006369,GO:0006378,GO:0006379,GO:0031123,GO:0031124" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA cleavage|RNA 3'-end processing|mRNA 3'-end processing" hsa03015 mRNA surveillance pathway CT45A1 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.117017865 0.159441852 541466 cancer/testis antigen family 45 member A1 "GO:0005515,GO:0032039,GO:0034472" protein binding|integrator complex|snRNA 3'-end processing CTAGE15 3.081612685 5.202069413 0.961155956 0.184764154 -2.436243205 0.338470402 1 0.107315378 0.01949624 441294 CTAGE family member 15 "GO:0005789,GO:0006888,GO:0009306,GO:0016021,GO:0035459,GO:0070971" endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|protein secretion|integral component of membrane|vesicle cargo loading|endoplasmic reticulum exit site CTAGE4 9.566900179 11.44455271 7.689247648 0.671869652 -0.573746729 0.681462136 1 0.232587488 0.153653533 100128553 CTAGE family member 4 "GO:0005575,GO:0005789,GO:0006888,GO:0008150,GO:0009306,GO:0016021,GO:0035459,GO:0070971" cellular_component|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|biological_process|protein secretion|integral component of membrane|vesicle cargo loading|endoplasmic reticulum exit site CTAGE8 11.60809898 14.56579436 8.650403604 0.593884782 -0.751745031 0.514922909 1 0.249871319 0.145911588 100142659 CTAGE family member 8 "GO:0005789,GO:0006888,GO:0009306,GO:0016021,GO:0035459,GO:0070971" endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|protein secretion|integral component of membrane|vesicle cargo loading|endoplasmic reticulum exit site CTAGE9 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.058715684 643854 CTAGE family member 9 "GO:0005789,GO:0006888,GO:0009306,GO:0016021,GO:0035459,GO:0070971" endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|protein secretion|integral component of membrane|vesicle cargo loading|endoplasmic reticulum exit site CTBP1 3209.826665 2966.219979 3453.43335 1.164253958 0.219405786 0.354639866 1 15.33188461 17.55150829 1487 C-terminal binding protein 1 "GO:0000122,GO:0001226,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006342,GO:0006468,GO:0008022,GO:0008134,GO:0008285,GO:0016616,GO:0017053,GO:0019079,GO:0019904,GO:0031065,GO:0035067,GO:0042802,GO:0045892,GO:0050872,GO:0051287,GO:0051726,GO:0055114,GO:0070491,GO:0090241" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription corepressor binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|chromatin silencing|protein phosphorylation|protein C-terminus binding|transcription factor binding|negative regulation of cell population proliferation|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|transcription repressor complex|viral genome replication|protein domain specific binding|positive regulation of histone deacetylation|negative regulation of histone acetylation|identical protein binding|negative regulation of transcription, DNA-templated|white fat cell differentiation|NAD binding|regulation of cell cycle|oxidation-reduction process|repressing transcription factor binding|negative regulation of histone H4 acetylation" "hsa04310,hsa04330,hsa05200,hsa05220" Wnt signaling pathway|Notch signaling pathway|Pathways in cancer|Chronic myeloid leukemia CTBP2 1283.997605 1258.900798 1309.094412 1.039870984 0.056404546 0.817672348 1 5.336819591 5.456738737 1488 C-terminal binding protein 2 "GO:0000122,GO:0001226,GO:0003682,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0008285,GO:0016081,GO:0016616,GO:0017053,GO:0019079,GO:0019901,GO:0035563,GO:0042974,GO:0044877,GO:0045892,GO:0045944,GO:0048386,GO:0048790,GO:0050872,GO:0051287,GO:0055114,GO:0098684,GO:0098831,GO:0098882,GO:0098978,GO:0098982,GO:0099523,GO:1990830" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription corepressor binding|chromatin binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|negative regulation of cell population proliferation|synaptic vesicle docking|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|transcription repressor complex|viral genome replication|protein kinase binding|positive regulation of chromatin binding|retinoic acid receptor binding|protein-containing complex binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of retinoic acid receptor signaling pathway|maintenance of presynaptic active zone structure|white fat cell differentiation|NAD binding|oxidation-reduction process|photoreceptor ribbon synapse|presynaptic active zone cytoplasmic component|structural constituent of presynaptic active zone|glutamatergic synapse|GABA-ergic synapse|presynaptic cytosol|cellular response to leukemia inhibitory factor" "hsa04310,hsa04330,hsa05200,hsa05220" Wnt signaling pathway|Notch signaling pathway|Pathways in cancer|Chronic myeloid leukemia other CTBS 1010.421631 977.9890497 1042.854212 1.06632504 0.092647271 0.708830381 1 7.943003822 8.328092834 1486 chitobiase "GO:0004568,GO:0005615,GO:0005764,GO:0006032,GO:0008061,GO:0009313" chitinase activity|extracellular space|lysosome|chitin catabolic process|chitin binding|oligosaccharide catabolic process CTC1 632.0545056 759.5021343 504.6068769 0.664391651 -0.589894151 0.02353598 0.846928903 5.758379458 3.761799331 80169 CST telomere replication complex component 1 "GO:0000723,GO:0000781,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006974,GO:0010389,GO:0010833,GO:0016233,GO:0032211,GO:0035264,GO:0042162,GO:0045740,GO:0048146,GO:0048536,GO:0048538,GO:0048539,GO:0071425,GO:0090399,GO:0098505,GO:1990879" "telomere maintenance|chromosome, telomeric region|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|cytosol|cellular response to DNA damage stimulus|regulation of G2/M transition of mitotic cell cycle|telomere maintenance via telomere lengthening|telomere capping|negative regulation of telomere maintenance via telomerase|multicellular organism growth|telomeric DNA binding|positive regulation of DNA replication|positive regulation of fibroblast proliferation|spleen development|thymus development|bone marrow development|hematopoietic stem cell proliferation|replicative senescence|G-rich strand telomeric DNA binding|CST complex" CTCF 1335.903828 1448.256125 1223.551532 0.844844714 -0.243241902 0.31150324 1 19.86909193 16.50540134 10664 CCCTC-binding factor "GO:0000122,GO:0000775,GO:0000793,GO:0000976,GO:0000978,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006306,GO:0006349,GO:0006357,GO:0007059,GO:0008270,GO:0008285,GO:0010216,GO:0010628,GO:0016584,GO:0031060,GO:0035065,GO:0040029,GO:0040030,GO:0043035,GO:0043565,GO:0045892,GO:0045893,GO:0070602,GO:0071459,GO:0071514" "negative regulation of transcription by RNA polymerase II|chromosome, centromeric region|condensed chromosome|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription by RNA polymerase II|chromosome segregation|zinc ion binding|negative regulation of cell population proliferation|maintenance of DNA methylation|positive regulation of gene expression|nucleosome positioning|regulation of histone methylation|regulation of histone acetylation|regulation of gene expression, epigenetic|regulation of molecular function, epigenetic|chromatin insulator sequence binding|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|regulation of centromeric sister chromatid cohesion|protein localization to chromosome, centromeric region|genetic imprinting" zf-C2H2 CTDNEP1 2227.971142 2157.818393 2298.123891 1.065021922 0.090883126 0.701848176 1 59.14679081 61.93853247 23399 CTD nuclear envelope phosphatase 1 "GO:0004721,GO:0004722,GO:0005515,GO:0005635,GO:0005737,GO:0005789,GO:0005811,GO:0006470,GO:0006998,GO:0007077,GO:0007276,GO:0007498,GO:0010867,GO:0016021,GO:0031965,GO:0034504,GO:0071595,GO:0090263,GO:0106306,GO:0106307" phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein binding|nuclear envelope|cytoplasm|endoplasmic reticulum membrane|lipid droplet|protein dephosphorylation|nuclear envelope organization|mitotic nuclear envelope disassembly|gamete generation|mesoderm development|positive regulation of triglyceride biosynthetic process|integral component of membrane|nuclear membrane|protein localization to nucleus|Nem1-Spo7 phosphatase complex|positive regulation of canonical Wnt signaling pathway|protein serine phosphatase activity|protein threonine phosphatase activity CTDP1 634.2252665 639.8545378 628.5959952 0.982404528 -0.025610885 0.927997099 1 8.64283996 8.348683656 9150 CTD phosphatase subunit 1 "GO:0000922,GO:0001096,GO:0004721,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005819,GO:0006366,GO:0006368,GO:0006470,GO:0008420,GO:0010458,GO:0030496,GO:0030957,GO:0032991,GO:0043231,GO:0043923,GO:0050434,GO:0051233,GO:0051301,GO:0061052,GO:0070940,GO:0106306,GO:0106307" spindle pole|TFIIF-class transcription factor complex binding|phosphoprotein phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|spindle|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|protein dephosphorylation|RNA polymerase II CTD heptapeptide repeat phosphatase activity|exit from mitosis|midbody|Tat protein binding|protein-containing complex|intracellular membrane-bounded organelle|positive regulation by host of viral transcription|positive regulation of viral transcription|spindle midzone|cell division|negative regulation of cell growth involved in cardiac muscle cell development|dephosphorylation of RNA polymerase II C-terminal domain|protein serine phosphatase activity|protein threonine phosphatase activity CTDSP1 1287.311961 1282.830317 1291.793605 1.006987119 0.010045228 0.970317496 1 16.98394847 16.81642819 58190 CTD small phosphatase 1 "GO:0004721,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006470,GO:0008420,GO:0046872,GO:0070062,GO:0106306,GO:0106307" phosphoprotein phosphatase activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|protein dephosphorylation|RNA polymerase II CTD heptapeptide repeat phosphatase activity|metal ion binding|extracellular exosome|protein serine phosphatase activity|protein threonine phosphatase activity CTDSP2 5085.771308 5231.201002 4940.341614 0.944399118 -0.0825314 0.731645616 1 34.7757328 32.29260213 10106 CTD small phosphatase 2 "GO:0001933,GO:0004721,GO:0005515,GO:0005654,GO:0006470,GO:0008420,GO:0036498,GO:0046872,GO:0106306,GO:0106307,GO:2000134" negative regulation of protein phosphorylation|phosphoprotein phosphatase activity|protein binding|nucleoplasm|protein dephosphorylation|RNA polymerase II CTD heptapeptide repeat phosphatase activity|IRE1-mediated unfolded protein response|metal ion binding|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of G1/S transition of mitotic cell cycle CTDSPL 851.984998 893.7155252 810.2544709 0.9066134 -0.14144061 0.573466389 1 9.107495704 8.118808306 10217 CTD small phosphatase like "GO:0001933,GO:0003674,GO:0004721,GO:0005515,GO:0005634,GO:0006470,GO:0008150,GO:0008420,GO:0046872,GO:0070062,GO:0106306,GO:0106307,GO:2000134" negative regulation of protein phosphorylation|molecular_function|phosphoprotein phosphatase activity|protein binding|nucleus|protein dephosphorylation|biological_process|RNA polymerase II CTD heptapeptide repeat phosphatase activity|metal ion binding|extracellular exosome|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of G1/S transition of mitotic cell cycle CTDSPL2 790.4370327 779.2699981 801.6040673 1.028660245 0.040766555 0.876395825 1 7.099386747 7.180653491 51496 CTD small phosphatase like 2 "GO:0004721,GO:0005515,GO:0005654,GO:0006470,GO:0008420,GO:0030514,GO:0046827" phosphoprotein phosphatase activity|protein binding|nucleoplasm|protein dephosphorylation|RNA polymerase II CTD heptapeptide repeat phosphatase activity|negative regulation of BMP signaling pathway|positive regulation of protein export from nucleus CTF1 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.062633927 0.085341408 1489 cardiotrophin 1 "GO:0005125,GO:0005146,GO:0005515,GO:0005576,GO:0005615,GO:0007166,GO:0007267,GO:0007517,GO:0008284,GO:0019221,GO:0030182,GO:0042531,GO:0048666,GO:0048861" cytokine activity|leukemia inhibitory factor receptor binding|protein binding|extracellular region|extracellular space|cell surface receptor signaling pathway|cell-cell signaling|muscle organ development|positive regulation of cell population proliferation|cytokine-mediated signaling pathway|neuron differentiation|positive regulation of tyrosine phosphorylation of STAT protein|neuron development|leukemia inhibitory factor signaling pathway "hsa04060,hsa04630" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway CTH 234.639097 305.8816815 163.3965125 0.534182079 -0.904596519 0.008396781 0.565645221 6.816009668 3.580063174 1491 cystathionine gamma-lyase "GO:0000098,GO:0004123,GO:0005515,GO:0005516,GO:0005737,GO:0005829,GO:0006534,GO:0016846,GO:0018272,GO:0019343,GO:0019344,GO:0019346,GO:0030170,GO:0030968,GO:0042802,GO:0043123,GO:0044524,GO:0044540,GO:0051092,GO:0051289,GO:0070062,GO:0070814,GO:0080146,GO:1904831,GO:1990830,GO:2001234" sulfur amino acid catabolic process|cystathionine gamma-lyase activity|protein binding|calmodulin binding|cytoplasm|cytosol|cysteine metabolic process|carbon-sulfur lyase activity|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine|cysteine biosynthetic process via cystathionine|cysteine biosynthetic process|transsulfuration|pyridoxal phosphate binding|endoplasmic reticulum unfolded protein response|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|protein sulfhydration|L-cystine L-cysteine-lyase (deaminating)|positive regulation of NF-kappaB transcription factor activity|protein homotetramerization|extracellular exosome|hydrogen sulfide biosynthetic process|L-cysteine desulfhydrase activity|positive regulation of aortic smooth muscle cell differentiation|cellular response to leukemia inhibitory factor|negative regulation of apoptotic signaling pathway "hsa00260,hsa00270,hsa00450" "Glycine, serine and threonine metabolism|Cysteine and methionine metabolism|Selenocompound metabolism" CTHRC1 184.9420348 199.7594655 170.1246042 0.851647274 -0.231672061 0.542677656 1 7.653119547 6.40869254 115908 collagen triple helix repeat containing 1 "GO:0005109,GO:0005201,GO:0005576,GO:0005581,GO:0005615,GO:0005737,GO:0016477,GO:0017147,GO:0032092,GO:0033690,GO:0043932,GO:0045669,GO:0060071,GO:0060122,GO:0062023,GO:0090090,GO:0090103,GO:0090177" "frizzled binding|extracellular matrix structural constituent|extracellular region|collagen trimer|extracellular space|cytoplasm|cell migration|Wnt-protein binding|positive regulation of protein binding|positive regulation of osteoblast proliferation|ossification involved in bone remodeling|positive regulation of osteoblast differentiation|Wnt signaling pathway, planar cell polarity pathway|inner ear receptor cell stereocilium organization|collagen-containing extracellular matrix|negative regulation of canonical Wnt signaling pathway|cochlea morphogenesis|establishment of planar polarity involved in neural tube closure" CTIF 1308.625969 1262.02204 1355.229898 1.073855967 0.102800502 0.671107473 1 9.500888243 10.03185908 9811 cap binding complex dependent translation initiation factor "GO:0000184,GO:0003723,GO:0005515,GO:0005829,GO:0006446,GO:0008494,GO:0045727,GO:0048471" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|protein binding|cytosol|regulation of translational initiation|translation activator activity|positive regulation of translation|perinuclear region of cytoplasm" CTNNA1 10680.00222 9945.316304 11414.68813 1.147745108 0.198802283 0.431800742 1 106.9224924 120.6662185 1495 catenin alpha 1 "GO:0001541,GO:0001669,GO:0003723,GO:0005198,GO:0005515,GO:0005829,GO:0005886,GO:0005911,GO:0005915,GO:0005925,GO:0007015,GO:0007155,GO:0007163,GO:0007406,GO:0007568,GO:0008013,GO:0008584,GO:0014704,GO:0015629,GO:0016264,GO:0016342,GO:0016600,GO:0017166,GO:0030027,GO:0030054,GO:0031103,GO:0034332,GO:0034613,GO:0042475,GO:0042802,GO:0043231,GO:0043297,GO:0043627,GO:0045295,GO:0045296,GO:0045880,GO:0051015,GO:0051149,GO:0071681,GO:0090136,GO:1900181,GO:2000146,GO:2001045,GO:2001240,GO:2001241" ovarian follicle development|acrosomal vesicle|RNA binding|structural molecule activity|protein binding|cytosol|plasma membrane|cell-cell junction|zonula adherens|focal adhesion|actin filament organization|cell adhesion|establishment or maintenance of cell polarity|negative regulation of neuroblast proliferation|aging|beta-catenin binding|male gonad development|intercalated disc|actin cytoskeleton|gap junction assembly|catenin complex|flotillin complex|vinculin binding|lamellipodium|cell junction|axon regeneration|adherens junction organization|cellular protein localization|odontogenesis of dentin-containing tooth|identical protein binding|intracellular membrane-bounded organelle|apical junction assembly|response to estrogen|gamma-catenin binding|cadherin binding|positive regulation of smoothened signaling pathway|actin filament binding|positive regulation of muscle cell differentiation|cellular response to indole-3-methanol|epithelial cell-cell adhesion|negative regulation of protein localization to nucleus|negative regulation of cell motility|negative regulation of integrin-mediated signaling pathway|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa04390,hsa04520,hsa04670,hsa05100,hsa05200,hsa05213,hsa05226,hsa05412" Hippo signaling pathway|Adherens junction|Leukocyte transendothelial migration|Bacterial invasion of epithelial cells|Pathways in cancer|Endometrial cancer|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy CTNNA2 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.024857946 1496 catenin alpha 2 "GO:0005200,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0007010,GO:0007409,GO:0010975,GO:0015629,GO:0021942,GO:0030424,GO:0034316,GO:0045296,GO:0048813,GO:0048854,GO:0051015,GO:0051149,GO:0051823,GO:0060134,GO:0098609,GO:2001222" structural constituent of cytoskeleton|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|adherens junction|cytoskeleton organization|axonogenesis|regulation of neuron projection development|actin cytoskeleton|radial glia guided migration of Purkinje cell|axon|negative regulation of Arp2/3 complex-mediated actin nucleation|cadherin binding|dendrite morphogenesis|brain morphogenesis|actin filament binding|positive regulation of muscle cell differentiation|regulation of synapse structural plasticity|prepulse inhibition|cell-cell adhesion|regulation of neuron migration "hsa04390,hsa04520,hsa04670,hsa05100,hsa05200,hsa05213,hsa05226,hsa05412" Hippo signaling pathway|Adherens junction|Leukocyte transendothelial migration|Bacterial invasion of epithelial cells|Pathways in cancer|Endometrial cancer|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy CTNNA3 10.8104893 6.242483296 15.3784953 2.463522058 1.300722389 0.255870018 1 0.024516142 0.059385412 29119 catenin alpha 3 "GO:0005515,GO:0005829,GO:0005856,GO:0005912,GO:0005916,GO:0007015,GO:0008013,GO:0030027,GO:0045296,GO:0051015,GO:0086073,GO:0086091,GO:0090136,GO:0098609,GO:0098911" protein binding|cytosol|cytoskeleton|adherens junction|fascia adherens|actin filament organization|beta-catenin binding|lamellipodium|cadherin binding|actin filament binding|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|regulation of heart rate by cardiac conduction|epithelial cell-cell adhesion|cell-cell adhesion|regulation of ventricular cardiac muscle cell action potential "hsa04390,hsa04520,hsa04670,hsa05100,hsa05200,hsa05213,hsa05226,hsa05412" Hippo signaling pathway|Adherens junction|Leukocyte transendothelial migration|Bacterial invasion of epithelial cells|Pathways in cancer|Endometrial cancer|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy CTNNAL1 4283.952545 3875.541713 4692.363377 1.210763224 0.27591676 0.247704552 1 82.79845407 98.5717865 8727 catenin alpha like 1 "GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0007155,GO:0007266,GO:0045296,GO:0051015" protein binding|cytosol|cytoskeleton|plasma membrane|cell adhesion|Rho protein signal transduction|cadherin binding|actin filament binding CTNNB1 6650.843478 6349.645926 6952.04103 1.094870661 0.130760451 0.59163272 1 85.10018405 91.61455914 1499 catenin beta 1 "GO:0000209,GO:0000791,GO:0000922,GO:0001085,GO:0001102,GO:0001569,GO:0001837,GO:0002052,GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0005911,GO:0005912,GO:0005925,GO:0005938,GO:0007155,GO:0007223,GO:0008013,GO:0008022,GO:0008134,GO:0008285,GO:0010718,GO:0010909,GO:0016020,GO:0016032,GO:0016055,GO:0016323,GO:0016328,GO:0016342,GO:0016525,GO:0019827,GO:0019899,GO:0019900,GO:0019903,GO:0030054,GO:0030331,GO:0030877,GO:0030997,GO:0032355,GO:0032481,GO:0032991,GO:0032993,GO:0033234,GO:0034333,GO:0034394,GO:0035257,GO:0035315,GO:0035635,GO:0035995,GO:0036023,GO:0042493,GO:0042995,GO:0043065,GO:0043066,GO:0043161,GO:0043525,GO:0044325,GO:0044334,GO:0044336,GO:0045202,GO:0045294,GO:0045296,GO:0045765,GO:0045892,GO:0045893,GO:0045944,GO:0045976,GO:0046332,GO:0048145,GO:0048471,GO:0048660,GO:0050767,GO:0051091,GO:0051149,GO:0051571,GO:0060070,GO:0060828,GO:0061154,GO:0061324,GO:0061549,GO:0070062,GO:0070369,GO:0070411,GO:0070602,GO:0071363,GO:0071681,GO:0071944,GO:0072182,GO:0090279,GO:0098609,GO:1904798,GO:1904837,GO:1904886,GO:1904948,GO:1904954,GO:1990138,GO:1990907,GO:1990909,GO:2000008,GO:2000144" "protein polyubiquitination|euchromatin|spindle pole|RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|branching involved in blood vessel morphogenesis|epithelial to mesenchymal transition|positive regulation of neuroblast proliferation|chromatin binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|centrosome|cytosol|plasma membrane|cell-cell junction|adherens junction|focal adhesion|cell cortex|cell adhesion|Wnt signaling pathway, calcium modulating pathway|beta-catenin binding|protein C-terminus binding|transcription factor binding|negative regulation of cell population proliferation|positive regulation of epithelial to mesenchymal transition|positive regulation of heparan sulfate proteoglycan biosynthetic process|membrane|viral process|Wnt signaling pathway|basolateral plasma membrane|lateral plasma membrane|catenin complex|negative regulation of angiogenesis|stem cell population maintenance|enzyme binding|kinase binding|protein phosphatase binding|cell junction|estrogen receptor binding|beta-catenin destruction complex|regulation of centriole-centriole cohesion|response to estradiol|positive regulation of type I interferon production|protein-containing complex|protein-DNA complex|negative regulation of protein sumoylation|adherens junction assembly|protein localization to cell surface|nuclear hormone receptor binding|hair cell differentiation|entry of bacterium into host cell|detection of muscle stretch|embryonic skeletal limb joint morphogenesis|response to drug|cell projection|positive regulation of apoptotic process|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of neuron apoptotic process|ion channel binding|canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition|canonical Wnt signaling pathway involved in negative regulation of apoptotic process|synapse|alpha-catenin binding|cadherin binding|regulation of angiogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of mitotic cell cycle, embryonic|SMAD binding|regulation of fibroblast proliferation|perinuclear region of cytoplasm|regulation of smooth muscle cell proliferation|regulation of neurogenesis|positive regulation of DNA-binding transcription factor activity|positive regulation of muscle cell differentiation|positive regulation of histone H3-K4 methylation|canonical Wnt signaling pathway|regulation of canonical Wnt signaling pathway|endothelial tube morphogenesis|canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation|sympathetic ganglion development|extracellular exosome|beta-catenin-TCF7L2 complex|I-SMAD binding|regulation of centromeric sister chromatid cohesion|cellular response to growth factor stimulus|cellular response to indole-3-methanol|cell periphery|regulation of nephron tubule epithelial cell differentiation|regulation of calcium ion import|cell-cell adhesion|positive regulation of core promoter binding|beta-catenin-TCF complex assembly|beta-catenin destruction complex disassembly|midbrain dopaminergic neuron differentiation|canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|neuron projection extension|beta-catenin-TCF complex|Wnt signalosome|regulation of protein localization to cell surface|positive regulation of DNA-templated transcription, initiation" "hsa04015,hsa04310,hsa04390,hsa04510,hsa04520,hsa04550,hsa04670,hsa04916,hsa04919,hsa04934,hsa05010,hsa05022,hsa05100,hsa05132,hsa05160,hsa05163,hsa05165,hsa05167,hsa05200,hsa05205,hsa05210,hsa05213,hsa05215,hsa05216,hsa05217,hsa05224,hsa05225,hsa05226,hsa05412,hsa05418" Rap1 signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Focal adhesion|Adherens junction|Signaling pathways regulating pluripotency of stem cells|Leukocyte transendothelial migration|Melanogenesis|Thyroid hormone signaling pathway|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Bacterial invasion of epithelial cells|Salmonella infection|Hepatitis C|Human cytomegalovirus infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Endometrial cancer|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy|Fluid shear stress and atherosclerosis other CTNNBIP1 507.1752716 483.7924554 530.5580877 1.096664658 0.133122441 0.629415673 1 7.602801582 8.198203281 56998 catenin beta interacting protein 1 "GO:0001658,GO:0002528,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008013,GO:0009952,GO:0016055,GO:0030178,GO:0030877,GO:0031333,GO:0032091,GO:0043392,GO:0043433,GO:0045657,GO:0045669,GO:0048662,GO:0060633,GO:0070016,GO:0072201" branching involved in ureteric bud morphogenesis|regulation of vascular permeability involved in acute inflammatory response|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|beta-catenin binding|anterior/posterior pattern specification|Wnt signaling pathway|negative regulation of Wnt signaling pathway|beta-catenin destruction complex|negative regulation of protein-containing complex assembly|negative regulation of protein binding|negative regulation of DNA binding|negative regulation of DNA-binding transcription factor activity|positive regulation of monocyte differentiation|positive regulation of osteoblast differentiation|negative regulation of smooth muscle cell proliferation|negative regulation of transcription initiation from RNA polymerase II promoter|armadillo repeat domain binding|negative regulation of mesenchymal cell proliferation hsa04310 Wnt signaling pathway CTNNBL1 1418.677711 1362.942186 1474.413236 1.081787072 0.113416561 0.637246677 1 32.98762789 35.08843937 56259 catenin beta like 1 "GO:0000398,GO:0000974,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005813,GO:0005829,GO:0006915,GO:0016020,GO:0016445,GO:0019899,GO:0043065" "mRNA splicing, via spliceosome|Prp19 complex|protein binding|nucleus|nucleoplasm|spliceosomal complex|centrosome|cytosol|apoptotic process|membrane|somatic diversification of immunoglobulins|enzyme binding|positive regulation of apoptotic process" hsa03040 Spliceosome CTNND1 5401.067633 5635.922002 5166.213263 0.916658048 -0.125544446 0.602479815 1 45.5932695 41.09408086 1500 catenin delta 1 "GO:0005102,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0005912,GO:0005915,GO:0007043,GO:0007420,GO:0016055,GO:0016342,GO:0019901,GO:0030027,GO:0030426,GO:0030496,GO:0034332,GO:0035635,GO:0043197,GO:0044331,GO:0045296,GO:0050821,GO:0070062,GO:0090090,GO:0098609,GO:0098685,GO:0098686,GO:0098831,GO:0098978,GO:0099072,GO:0099092" "signaling receptor binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|cell-cell junction|adherens junction|zonula adherens|cell-cell junction assembly|brain development|Wnt signaling pathway|catenin complex|protein kinase binding|lamellipodium|growth cone|midbody|adherens junction organization|entry of bacterium into host cell|dendritic spine|cell-cell adhesion mediated by cadherin|cadherin binding|protein stabilization|extracellular exosome|negative regulation of canonical Wnt signaling pathway|cell-cell adhesion|Schaffer collateral - CA1 synapse|hippocampal mossy fiber to CA3 synapse|presynaptic active zone cytoplasmic component|glutamatergic synapse|regulation of postsynaptic membrane neurotransmitter receptor levels|postsynaptic density, intracellular component" "hsa04015,hsa04520,hsa04670" Rap1 signaling pathway|Adherens junction|Leukocyte transendothelial migration CTNS 405.6990907 469.2266611 342.1715203 0.729224379 -0.455565302 0.113550161 1 5.569787478 3.993659021 1497 "cystinosin, lysosomal cystine transporter" "GO:0002088,GO:0005764,GO:0005765,GO:0005769,GO:0005770,GO:0005774,GO:0005886,GO:0006520,GO:0006749,GO:0006811,GO:0007420,GO:0007616,GO:0007625,GO:0007628,GO:0008542,GO:0010730,GO:0010918,GO:0015184,GO:0015811,GO:0016021,GO:0042438,GO:0042470,GO:0043231,GO:0045111,GO:0046034,GO:0050890,GO:0055085,GO:0070062" lens development in camera-type eye|lysosome|lysosomal membrane|early endosome|late endosome|vacuolar membrane|plasma membrane|cellular amino acid metabolic process|glutathione metabolic process|ion transport|brain development|long-term memory|grooming behavior|adult walking behavior|visual learning|negative regulation of hydrogen peroxide biosynthetic process|positive regulation of mitochondrial membrane potential|L-cystine transmembrane transporter activity|L-cystine transport|integral component of membrane|melanin biosynthetic process|melanosome|intracellular membrane-bounded organelle|intermediate filament cytoskeleton|ATP metabolic process|cognition|transmembrane transport|extracellular exosome hsa04142 Lysosome CTPS1 1827.468476 1812.400984 1842.535968 1.016627106 0.023790603 0.92242664 1 23.70698761 23.69786584 1503 CTP synthase 1 "GO:0003883,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006139,GO:0006241,GO:0006541,GO:0015949,GO:0016020,GO:0019856,GO:0042098,GO:0042100,GO:0042493,GO:0042802,GO:0044210,GO:0097268" CTP synthase activity|protein binding|ATP binding|cytoplasm|cytosol|nucleobase-containing compound metabolic process|CTP biosynthetic process|glutamine metabolic process|nucleobase-containing small molecule interconversion|membrane|pyrimidine nucleobase biosynthetic process|T cell proliferation|B cell proliferation|response to drug|identical protein binding|'de novo' CTP biosynthetic process|cytoophidium hsa00240 Pyrimidine metabolism CTPS2 898.7545473 910.3621473 887.1469474 0.97449894 -0.037267479 0.885126195 1 9.548811837 9.149595301 56474 CTP synthase 2 "GO:0003883,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006220,GO:0006241,GO:0006541,GO:0015949,GO:0019856,GO:0042802,GO:0044210,GO:0097268" CTP synthase activity|protein binding|ATP binding|cytoplasm|cytosol|pyrimidine nucleotide metabolic process|CTP biosynthetic process|glutamine metabolic process|nucleobase-containing small molecule interconversion|pyrimidine nucleobase biosynthetic process|identical protein binding|'de novo' CTP biosynthetic process|cytoophidium hsa00240 Pyrimidine metabolism CTR9 1368.300698 1453.458194 1283.143201 0.882820852 -0.179807389 0.454238318 1 17.9141784 15.55036746 9646 "CTR9 homolog, Paf1/RNA polymerase II complex component" "GO:0000122,GO:0000993,GO:0001711,GO:0001826,GO:0001829,GO:0001832,GO:0001835,GO:0005515,GO:0005654,GO:0006355,GO:0006366,GO:0006368,GO:0007259,GO:0010390,GO:0016055,GO:0016567,GO:0016593,GO:0016607,GO:0019827,GO:0033523,GO:0035327,GO:0042169,GO:0045638,GO:0051569,GO:0051571,GO:0070102,GO:0071222,GO:0080182,GO:1900364,GO:2000653,GO:2001162,GO:2001168" "negative regulation of transcription by RNA polymerase II|RNA polymerase II complex binding|endodermal cell fate commitment|inner cell mass cell differentiation|trophectodermal cell differentiation|blastocyst growth|blastocyst hatching|protein binding|nucleoplasm|regulation of transcription, DNA-templated|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|receptor signaling pathway via JAK-STAT|histone monoubiquitination|Wnt signaling pathway|protein ubiquitination|Cdc73/Paf1 complex|nuclear speck|stem cell population maintenance|histone H2B ubiquitination|transcriptionally active chromatin|SH2 domain binding|negative regulation of myeloid cell differentiation|regulation of histone H3-K4 methylation|positive regulation of histone H3-K4 methylation|interleukin-6-mediated signaling pathway|cellular response to lipopolysaccharide|histone H3-K4 trimethylation|negative regulation of mRNA polyadenylation|regulation of genetic imprinting|positive regulation of histone H3-K79 methylation|positive regulation of histone H2B ubiquitination" CTRL 7.045123399 8.323311061 5.766935736 0.692865579 -0.529352609 0.780164403 1 0.381287394 0.259760201 1506 chymotrypsin like "GO:0004252,GO:0005515,GO:0005615,GO:0006508,GO:0008236,GO:0030163" serine-type endopeptidase activity|protein binding|extracellular space|proteolysis|serine-type peptidase activity|protein catabolic process "hsa04972,hsa04974" Pancreatic secretion|Protein digestion and absorption CTSA 4613.946185 4678.74123 4549.15114 0.97230236 -0.040523072 0.866305055 1 81.89433267 78.29361876 5476 cathepsin A "GO:0004180,GO:0004185,GO:0005576,GO:0005764,GO:0005783,GO:0006508,GO:0006687,GO:0006886,GO:0008047,GO:0016020,GO:0031647,GO:0035578,GO:0043202,GO:0043231,GO:0043312,GO:0050790,GO:0070062,GO:0098575,GO:1904714,GO:1904715" carboxypeptidase activity|serine-type carboxypeptidase activity|extracellular region|lysosome|endoplasmic reticulum|proteolysis|glycosphingolipid metabolic process|intracellular protein transport|enzyme activator activity|membrane|regulation of protein stability|azurophil granule lumen|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|regulation of catalytic activity|extracellular exosome|lumenal side of lysosomal membrane|regulation of chaperone-mediated autophagy|negative regulation of chaperone-mediated autophagy "hsa04142,hsa04614" Lysosome|Renin-angiotensin system CTSB 16873.99591 16047.34373 17700.64809 1.103026668 0.141467672 0.595745992 1 173.8918256 188.5976852 1508 cathepsin B "GO:0002224,GO:0004197,GO:0005515,GO:0005518,GO:0005576,GO:0005615,GO:0005622,GO:0005764,GO:0006508,GO:0008233,GO:0008234,GO:0016324,GO:0030574,GO:0030855,GO:0036021,GO:0042470,GO:0042981,GO:0043312,GO:0043394,GO:0048471,GO:0050790,GO:0051603,GO:0062023,GO:0070062,GO:0097067,GO:1904813" toll-like receptor signaling pathway|cysteine-type endopeptidase activity|protein binding|collagen binding|extracellular region|extracellular space|intracellular anatomical structure|lysosome|proteolysis|peptidase activity|cysteine-type peptidase activity|apical plasma membrane|collagen catabolic process|epithelial cell differentiation|endolysosome lumen|melanosome|regulation of apoptotic process|neutrophil degranulation|proteoglycan binding|perinuclear region of cytoplasm|regulation of catalytic activity|proteolysis involved in cellular protein catabolic process|collagen-containing extracellular matrix|extracellular exosome|cellular response to thyroid hormone stimulus|ficolin-1-rich granule lumen "hsa04140,hsa04142,hsa04210,hsa04612,hsa04621,hsa04924" Autophagy - animal|Lysosome|Apoptosis|Antigen processing and presentation|NOD-like receptor signaling pathway|Renin secretion CTSC 2852.005505 2744.611822 2959.399189 1.07825783 0.108702193 0.646674313 1 19.30349085 20.46584371 1075 cathepsin C "GO:0000139,GO:0001913,GO:0004197,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005654,GO:0005764,GO:0005788,GO:0005813,GO:0006508,GO:0006888,GO:0006915,GO:0006955,GO:0007568,GO:0008234,GO:0008239,GO:0010033,GO:0016020,GO:0016505,GO:0019902,GO:0030134,GO:0031404,GO:0031642,GO:0033116,GO:0035578,GO:0042802,GO:0043231,GO:0043312,GO:0043621,GO:0048208,GO:0051087,GO:0051603,GO:0062023,GO:0070062,GO:1903052,GO:1903980,GO:2001235" Golgi membrane|T cell mediated cytotoxicity|cysteine-type endopeptidase activity|serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|nucleoplasm|lysosome|endoplasmic reticulum lumen|centrosome|proteolysis|endoplasmic reticulum to Golgi vesicle-mediated transport|apoptotic process|immune response|aging|cysteine-type peptidase activity|dipeptidyl-peptidase activity|response to organic substance|membrane|peptidase activator activity involved in apoptotic process|phosphatase binding|COPII-coated ER to Golgi transport vesicle|chloride ion binding|negative regulation of myelination|endoplasmic reticulum-Golgi intermediate compartment membrane|azurophil granule lumen|identical protein binding|intracellular membrane-bounded organelle|neutrophil degranulation|protein self-association|COPII vesicle coating|chaperone binding|proteolysis involved in cellular protein catabolic process|collagen-containing extracellular matrix|extracellular exosome|positive regulation of proteolysis involved in cellular protein catabolic process|positive regulation of microglial cell activation|positive regulation of apoptotic signaling pathway "hsa04142,hsa04210" Lysosome|Apoptosis CTSD 3743.707441 4062.816212 3424.598671 0.842912525 -0.246545175 0.299723709 1 105.5109655 87.4482822 1509 cathepsin D "GO:0004190,GO:0005515,GO:0005576,GO:0005615,GO:0005764,GO:0005765,GO:0006508,GO:0008233,GO:0010008,GO:0019886,GO:0030574,GO:0035580,GO:0042159,GO:0042470,GO:0043065,GO:0043202,GO:0043280,GO:0043312,GO:0045121,GO:0062023,GO:0070001,GO:0070062,GO:0070201,GO:1904724,GO:1904813" aspartic-type endopeptidase activity|protein binding|extracellular region|extracellular space|lysosome|lysosomal membrane|proteolysis|peptidase activity|endosome membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|collagen catabolic process|specific granule lumen|lipoprotein catabolic process|melanosome|positive regulation of apoptotic process|lysosomal lumen|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|neutrophil degranulation|membrane raft|collagen-containing extracellular matrix|aspartic-type peptidase activity|extracellular exosome|regulation of establishment of protein localization|tertiary granule lumen|ficolin-1-rich granule lumen "hsa04071,hsa04140,hsa04142,hsa04210,hsa04915,hsa05152" Sphingolipid signaling pathway|Autophagy - animal|Lysosome|Apoptosis|Estrogen signaling pathway|Tuberculosis CTSF 238.3503571 239.295193 237.4055211 0.992103177 -0.011437929 0.987177743 1 6.087104216 5.937980349 8722 cathepsin F "GO:0004197,GO:0005615,GO:0005764,GO:0006508,GO:0019886,GO:0043202,GO:0051603,GO:0062023,GO:0070062,GO:1903561" cysteine-type endopeptidase activity|extracellular space|lysosome|proteolysis|antigen processing and presentation of exogenous peptide antigen via MHC class II|lysosomal lumen|proteolysis involved in cellular protein catabolic process|collagen-containing extracellular matrix|extracellular exosome|extracellular vesicle "hsa04142,hsa04210" Lysosome|Apoptosis CTSH 328.6883417 365.1852728 292.1914106 0.800118275 -0.321714817 0.294087597 1 6.833543768 5.376149649 1512 cathepsin H "GO:0001656,GO:0001913,GO:0002250,GO:0002764,GO:0004175,GO:0004177,GO:0004197,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005764,GO:0005829,GO:0006508,GO:0006919,GO:0008233,GO:0008234,GO:0008284,GO:0008656,GO:0010628,GO:0010634,GO:0010813,GO:0010815,GO:0010952,GO:0019882,GO:0030108,GO:0030335,GO:0031638,GO:0031648,GO:0032526,GO:0033619,GO:0034774,GO:0036464,GO:0043066,GO:0043129,GO:0043231,GO:0043312,GO:0044267,GO:0045766,GO:0051603,GO:0060448,GO:0062023,GO:0070062,GO:0070324,GO:0070371,GO:0097067,GO:0097208,GO:0097486,GO:1904724,GO:1904813" metanephros development|T cell mediated cytotoxicity|adaptive immune response|immune response-regulating signaling pathway|endopeptidase activity|aminopeptidase activity|cysteine-type endopeptidase activity|serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|lysosome|cytosol|proteolysis|activation of cysteine-type endopeptidase activity involved in apoptotic process|peptidase activity|cysteine-type peptidase activity|positive regulation of cell population proliferation|cysteine-type endopeptidase activator activity involved in apoptotic process|positive regulation of gene expression|positive regulation of epithelial cell migration|neuropeptide catabolic process|bradykinin catabolic process|positive regulation of peptidase activity|antigen processing and presentation|HLA-A specific activating MHC class I receptor activity|positive regulation of cell migration|zymogen activation|protein destabilization|response to retinoic acid|membrane protein proteolysis|secretory granule lumen|cytoplasmic ribonucleoprotein granule|negative regulation of apoptotic process|surfactant homeostasis|intracellular membrane-bounded organelle|neutrophil degranulation|cellular protein metabolic process|positive regulation of angiogenesis|proteolysis involved in cellular protein catabolic process|dichotomous subdivision of terminal units involved in lung branching|collagen-containing extracellular matrix|extracellular exosome|thyroid hormone binding|ERK1 and ERK2 cascade|cellular response to thyroid hormone stimulus|alveolar lamellar body|multivesicular body lumen|tertiary granule lumen|ficolin-1-rich granule lumen "hsa04142,hsa04210" Lysosome|Apoptosis CTSK 159.6946989 142.5367019 176.8526959 1.240751985 0.311214763 0.437185715 1 4.669688036 5.696971218 1513 cathepsin K "GO:0000422,GO:0001968,GO:0002224,GO:0004197,GO:0005515,GO:0005518,GO:0005576,GO:0005615,GO:0005654,GO:0005764,GO:0006508,GO:0006590,GO:0006955,GO:0008234,GO:0016324,GO:0022617,GO:0030574,GO:0036021,GO:0043202,GO:0043231,GO:0043394,GO:0045616,GO:0051603" autophagy of mitochondrion|fibronectin binding|toll-like receptor signaling pathway|cysteine-type endopeptidase activity|protein binding|collagen binding|extracellular region|extracellular space|nucleoplasm|lysosome|proteolysis|thyroid hormone generation|immune response|cysteine-type peptidase activity|apical plasma membrane|extracellular matrix disassembly|collagen catabolic process|endolysosome lumen|lysosomal lumen|intracellular membrane-bounded organelle|proteoglycan binding|regulation of keratinocyte differentiation|proteolysis involved in cellular protein catabolic process "hsa04142,hsa04210,hsa04380,hsa04620,hsa05323" Lysosome|Apoptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|Rheumatoid arthritis CTSL 2900.753316 2523.003665 3278.502966 1.299444393 0.377894898 0.110431785 1 83.47679389 106.6582954 1514 cathepsin L "GO:0001968,GO:0002224,GO:0002250,GO:0004197,GO:0005515,GO:0005518,GO:0005576,GO:0005615,GO:0005634,GO:0005764,GO:0005771,GO:0005794,GO:0005886,GO:0006508,GO:0006955,GO:0008234,GO:0016324,GO:0016540,GO:0019064,GO:0019065,GO:0019882,GO:0019886,GO:0022617,GO:0030574,GO:0031638,GO:0034230,GO:0036021,GO:0039654,GO:0042393,GO:0042583,GO:0043202,GO:0043231,GO:0043373,GO:0043394,GO:0045616,GO:0046718,GO:0048002,GO:0051603,GO:0060309,GO:0062023,GO:0070062,GO:0071888,GO:0097067,GO:0097655" "fibronectin binding|toll-like receptor signaling pathway|adaptive immune response|cysteine-type endopeptidase activity|protein binding|collagen binding|extracellular region|extracellular space|nucleus|lysosome|multivesicular body|Golgi apparatus|plasma membrane|proteolysis|immune response|cysteine-type peptidase activity|apical plasma membrane|protein autoprocessing|fusion of virus membrane with host plasma membrane|receptor-mediated endocytosis of virus by host cell|antigen processing and presentation|antigen processing and presentation of exogenous peptide antigen via MHC class II|extracellular matrix disassembly|collagen catabolic process|zymogen activation|enkephalin processing|endolysosome lumen|fusion of virus membrane with host endosome membrane|histone binding|chromaffin granule|lysosomal lumen|intracellular membrane-bounded organelle|CD4-positive, alpha-beta T cell lineage commitment|proteoglycan binding|regulation of keratinocyte differentiation|viral entry into host cell|antigen processing and presentation of peptide antigen|proteolysis involved in cellular protein catabolic process|elastin catabolic process|collagen-containing extracellular matrix|extracellular exosome|macrophage apoptotic process|cellular response to thyroid hormone stimulus|serpin family protein binding" "hsa04140,hsa04142,hsa04145,hsa04210,hsa04612,hsa05205,hsa05323,hsa05418" Autophagy - animal|Lysosome|Phagosome|Apoptosis|Antigen processing and presentation|Proteoglycans in cancer|Rheumatoid arthritis|Fluid shear stress and atherosclerosis CTSO 101.3170506 111.3242854 91.30981582 0.820214704 -0.285926488 0.548876278 1 2.046563041 1.650531648 1519 cathepsin O "GO:0004197,GO:0005515,GO:0005615,GO:0005764,GO:0006508,GO:0051603" cysteine-type endopeptidase activity|protein binding|extracellular space|lysosome|proteolysis|proteolysis involved in cellular protein catabolic process "hsa04142,hsa04210" Lysosome|Apoptosis CTSS 455.9962321 477.5499721 434.4424921 0.909732002 -0.136486491 0.629861294 1 6.475092559 5.79202772 1520 cathepsin S "GO:0001968,GO:0002224,GO:0002250,GO:0004197,GO:0005518,GO:0005576,GO:0005615,GO:0005764,GO:0005770,GO:0006508,GO:0006955,GO:0010447,GO:0016485,GO:0019882,GO:0019886,GO:0022617,GO:0030574,GO:0034769,GO:0036021,GO:0043202,GO:0043231,GO:0043236,GO:0043312,GO:0043394,GO:0045335,GO:0048002,GO:0051603,GO:0062023,GO:0097067,GO:1904724,GO:1904813,GO:2001259" fibronectin binding|toll-like receptor signaling pathway|adaptive immune response|cysteine-type endopeptidase activity|collagen binding|extracellular region|extracellular space|lysosome|late endosome|proteolysis|immune response|response to acidic pH|protein processing|antigen processing and presentation|antigen processing and presentation of exogenous peptide antigen via MHC class II|extracellular matrix disassembly|collagen catabolic process|basement membrane disassembly|endolysosome lumen|lysosomal lumen|intracellular membrane-bounded organelle|laminin binding|neutrophil degranulation|proteoglycan binding|phagocytic vesicle|antigen processing and presentation of peptide antigen|proteolysis involved in cellular protein catabolic process|collagen-containing extracellular matrix|cellular response to thyroid hormone stimulus|tertiary granule lumen|ficolin-1-rich granule lumen|positive regulation of cation channel activity "hsa04142,hsa04145,hsa04210,hsa04612,hsa05152" Lysosome|Phagosome|Apoptosis|Antigen processing and presentation|Tuberculosis CTSV 535.409871 581.5913604 489.2283816 0.841189218 -0.249497737 0.355087999 1 7.060614646 5.839926554 1515 cathepsin V "GO:0004197,GO:0005515,GO:0005576,GO:0005615,GO:0005764,GO:0006955,GO:0008234,GO:0019886,GO:0022617,GO:0043202,GO:0045616,GO:0051603" cysteine-type endopeptidase activity|protein binding|extracellular region|extracellular space|lysosome|immune response|cysteine-type peptidase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|extracellular matrix disassembly|lysosomal lumen|regulation of keratinocyte differentiation|proteolysis involved in cellular protein catabolic process "hsa04142,hsa04210" Lysosome|Apoptosis CTSW 5.925451589 4.161655531 7.689247648 1.847641543 0.88568489 0.619277139 1 0.174606845 0.317212405 1521 cathepsin W "GO:0002576,GO:0004197,GO:0005576,GO:0005615,GO:0005764,GO:0005783,GO:0006955,GO:0008234,GO:0016020,GO:0031089,GO:0051603" platelet degranulation|cysteine-type endopeptidase activity|extracellular region|extracellular space|lysosome|endoplasmic reticulum|immune response|cysteine-type peptidase activity|membrane|platelet dense granule lumen|proteolysis involved in cellular protein catabolic process "hsa04142,hsa04210" Lysosome|Apoptosis CTSZ 4267.537437 4062.816212 4472.258663 1.10077799 0.138523529 0.561875853 1 144.357546 156.2465391 1522 cathepsin Z "GO:0000139,GO:0002003,GO:0004180,GO:0004197,GO:0005515,GO:0005576,GO:0005615,GO:0005764,GO:0005783,GO:0005788,GO:0005886,GO:0006508,GO:0006888,GO:0008234,GO:0010757,GO:0030134,GO:0031410,GO:0032091,GO:0033116,GO:0035580,GO:0043312,GO:0048208,GO:0051603,GO:0062023,GO:0070062,GO:0099738,GO:1901214,GO:1904813" Golgi membrane|angiotensin maturation|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding|extracellular region|extracellular space|lysosome|endoplasmic reticulum|endoplasmic reticulum lumen|plasma membrane|proteolysis|endoplasmic reticulum to Golgi vesicle-mediated transport|cysteine-type peptidase activity|negative regulation of plasminogen activation|COPII-coated ER to Golgi transport vesicle|cytoplasmic vesicle|negative regulation of protein binding|endoplasmic reticulum-Golgi intermediate compartment membrane|specific granule lumen|neutrophil degranulation|COPII vesicle coating|proteolysis involved in cellular protein catabolic process|collagen-containing extracellular matrix|extracellular exosome|cell cortex region|regulation of neuron death|ficolin-1-rich granule lumen "hsa04142,hsa04210" Lysosome|Apoptosis CTTN 5732.145616 5735.801735 5728.489498 0.998725159 -0.001840381 0.994741609 1 73.99303762 72.66211343 2017 cortactin "GO:0001726,GO:0002102,GO:0005515,GO:0005522,GO:0005737,GO:0005794,GO:0005829,GO:0005856,GO:0005884,GO:0005886,GO:0005905,GO:0005925,GO:0005938,GO:0006886,GO:0006898,GO:0006930,GO:0008076,GO:0030027,GO:0030041,GO:0030426,GO:0030427,GO:0030516,GO:0030833,GO:0030838,GO:0030863,GO:0030864,GO:0031532,GO:0043197,GO:0043231,GO:0045296,GO:0045987,GO:0048041,GO:0048812,GO:0048870,GO:0051015,GO:0061024,GO:0097062,GO:0097581,GO:1903146,GO:1990023,GO:2001237" "ruffle|podosome|protein binding|profilin binding|cytoplasm|Golgi apparatus|cytosol|cytoskeleton|actin filament|plasma membrane|clathrin-coated pit|focal adhesion|cell cortex|intracellular protein transport|receptor-mediated endocytosis|substrate-dependent cell migration, cell extension|voltage-gated potassium channel complex|lamellipodium|actin filament polymerization|growth cone|site of polarized growth|regulation of axon extension|regulation of actin filament polymerization|positive regulation of actin filament polymerization|cortical cytoskeleton|cortical actin cytoskeleton|actin cytoskeleton reorganization|dendritic spine|intracellular membrane-bounded organelle|cadherin binding|positive regulation of smooth muscle contraction|focal adhesion assembly|neuron projection morphogenesis|cell motility|actin filament binding|membrane organization|dendritic spine maintenance|lamellipodium organization|regulation of autophagy of mitochondrion|mitotic spindle midzone|negative regulation of extrinsic apoptotic signaling pathway" "hsa04530,hsa05100,hsa05130,hsa05131,hsa05205" Tight junction|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Proteoglycans in cancer CTTNBP2NL 1589.865424 1706.278768 1473.452081 0.863547099 -0.211653228 0.374282817 1 15.35857005 13.04091281 55917 CTTNBP2 N-terminal like "GO:0005515,GO:0005737,GO:0006470,GO:0015629,GO:0030027,GO:0032410,GO:0034763,GO:0051721" protein binding|cytoplasm|protein dephosphorylation|actin cytoskeleton|lamellipodium|negative regulation of transporter activity|negative regulation of transmembrane transport|protein phosphatase 2A binding CTU1 91.20037538 72.82897178 109.571779 1.504508114 0.589291887 0.224588468 1 1.828197728 2.704511782 90353 cytosolic thiouridylase subunit 1 "GO:0000049,GO:0002098,GO:0002143,GO:0002144,GO:0005515,GO:0005829,GO:0006400,GO:0016779,GO:0032447,GO:0034227" tRNA binding|tRNA wobble uridine modification|tRNA wobble position uridine thiolation|cytosolic tRNA wobble base thiouridylase complex|protein binding|cytosol|tRNA modification|nucleotidyltransferase activity|protein urmylation|tRNA thio-modification hsa04122 Sulfur relay system CTU2 320.0284917 289.2350594 350.8219239 1.21293015 0.278496471 0.368887862 1 7.89158667 9.411769894 348180 cytosolic thiouridylase subunit 2 "GO:0000049,GO:0002098,GO:0002143,GO:0005515,GO:0005829,GO:0006400,GO:0016779,GO:0016783,GO:0032447,GO:0032991,GO:0034227" tRNA binding|tRNA wobble uridine modification|tRNA wobble position uridine thiolation|protein binding|cytosol|tRNA modification|nucleotidyltransferase activity|sulfurtransferase activity|protein urmylation|protein-containing complex|tRNA thio-modification hsa04122 Sulfur relay system CTXN1 83.31298292 67.62690237 98.99906347 1.463900608 0.549817604 0.273484483 1 2.917642269 4.199666575 404217 cortexin 1 GO:0016021 integral component of membrane CUBN 41.38381194 64.50566072 18.26196316 0.283106366 -1.820583907 0.005744736 0.458837827 0.242706469 0.067561948 8029 cubilin "GO:0001894,GO:0005509,GO:0005515,GO:0005765,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0005905,GO:0006898,GO:0008203,GO:0009235,GO:0009617,GO:0010008,GO:0015889,GO:0016020,GO:0016324,GO:0030139,GO:0031232,GO:0031419,GO:0031526,GO:0034384,GO:0038023,GO:0038024,GO:0042359,GO:0042803,GO:0042953,GO:0043202,GO:0043235,GO:0070062" tissue homeostasis|calcium ion binding|protein binding|lysosomal membrane|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|clathrin-coated pit|receptor-mediated endocytosis|cholesterol metabolic process|cobalamin metabolic process|response to bacterium|endosome membrane|cobalamin transport|membrane|apical plasma membrane|endocytic vesicle|extrinsic component of external side of plasma membrane|cobalamin binding|brush border membrane|high-density lipoprotein particle clearance|signaling receptor activity|cargo receptor activity|vitamin D metabolic process|protein homodimerization activity|lipoprotein transport|lysosomal lumen|receptor complex|extracellular exosome hsa04977 Vitamin digestion and absorption CUEDC1 678.0365061 742.8555122 613.2174999 0.825486908 -0.27668276 0.282981066 1 9.69074392 7.86572006 404093 CUE domain containing 1 "GO:0005515,GO:0043130" protein binding|ubiquitin binding CUEDC2 2277.426014 2169.262945 2385.589083 1.099723336 0.137140622 0.562532354 1 105.2450695 113.8036991 79004 CUE domain containing 2 "GO:0005515,GO:0005654,GO:0005829,GO:0010936,GO:0031965,GO:0043130,GO:1900016" protein binding|nucleoplasm|cytosol|negative regulation of macrophage cytokine production|nuclear membrane|ubiquitin binding|negative regulation of cytokine production involved in inflammatory response CUL1 1599.705311 1636.571037 1562.839584 0.9549476 -0.066506523 0.781963346 1 20.2271395 18.99263359 8454 cullin 1 "GO:0000082,GO:0000086,GO:0000209,GO:0002223,GO:0004842,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006513,GO:0006879,GO:0008283,GO:0009887,GO:0010265,GO:0010972,GO:0016032,GO:0016055,GO:0016567,GO:0019005,GO:0031146,GO:0031461,GO:0031625,GO:0038061,GO:0038095,GO:0043687,GO:0050852,GO:0051403,GO:0070498,GO:0070936,GO:0097193,GO:1901990,GO:1990452" G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytosol|plasma membrane|protein monoubiquitination|cellular iron ion homeostasis|cell population proliferation|animal organ morphogenesis|SCF complex assembly|negative regulation of G2/M transition of mitotic cell cycle|viral process|Wnt signaling pathway|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cullin-RING ubiquitin ligase complex|ubiquitin protein ligase binding|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|post-translational protein modification|T cell receptor signaling pathway|stress-activated MAPK cascade|interleukin-1-mediated signaling pathway|protein K48-linked ubiquitination|intrinsic apoptotic signaling pathway|regulation of mitotic cell cycle phase transition|Parkin-FBXW7-Cul1 ubiquitin ligase complex "hsa04110,hsa04114,hsa04120,hsa04141,hsa04310,hsa04340,hsa04350,hsa04710,hsa05131,hsa05170,hsa05200" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Wnt signaling pathway|Hedgehog signaling pathway|TGF-beta signaling pathway|Circadian rhythm|Shigellosis|Human immunodeficiency virus 1 infection|Pathways in cancer CUL2 1346.774683 1304.679009 1388.870356 1.064530315 0.090217035 0.709217398 1 13.31834751 13.94053865 8453 cullin 2 "GO:0000082,GO:0004842,GO:0005515,GO:0005654,GO:0005829,GO:0016032,GO:0016567,GO:0019005,GO:0030891,GO:0031146,GO:0031461,GO:0031462,GO:0031625,GO:0043687,GO:0044877,GO:0061418,GO:0097193" G1/S transition of mitotic cell cycle|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytosol|viral process|protein ubiquitination|SCF ubiquitin ligase complex|VCB complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cullin-RING ubiquitin ligase complex|Cul2-RING ubiquitin ligase complex|ubiquitin protein ligase binding|post-translational protein modification|protein-containing complex binding|regulation of transcription from RNA polymerase II promoter in response to hypoxia|intrinsic apoptotic signaling pathway "hsa04066,hsa04120,hsa05200,hsa05211" HIF-1 signaling pathway|Ubiquitin mediated proteolysis|Pathways in cancer|Renal cell carcinoma CUL3 1927.497892 1839.451745 2015.54404 1.095730859 0.131893477 0.578431125 1 13.46244636 14.50437625 8452 cullin 3 "GO:0000082,GO:0000122,GO:0000139,GO:0000165,GO:0000209,GO:0000922,GO:0001831,GO:0004842,GO:0005112,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005827,GO:0005829,GO:0005886,GO:0006511,GO:0006513,GO:0006888,GO:0007080,GO:0007229,GO:0007369,GO:0008284,GO:0016020,GO:0016055,GO:0016477,GO:0016567,GO:0017145,GO:0030030,GO:0030332,GO:0031145,GO:0031208,GO:0031398,GO:0031461,GO:0031463,GO:0031625,GO:0031648,GO:0032467,GO:0035024,GO:0036126,GO:0040016,GO:0043149,GO:0043161,GO:0043687,GO:0044346,GO:0045842,GO:0048208,GO:0051865,GO:0061630,GO:0070062,GO:0071630,GO:0072576,GO:0072686,GO:0090090,GO:0097193,GO:1901992" G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|Golgi membrane|MAPK cascade|protein polyubiquitination|spindle pole|trophectodermal cellular morphogenesis|ubiquitin-protein transferase activity|Notch binding|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|polar microtubule|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|protein monoubiquitination|endoplasmic reticulum to Golgi vesicle-mediated transport|mitotic metaphase plate congression|integrin-mediated signaling pathway|gastrulation|positive regulation of cell population proliferation|membrane|Wnt signaling pathway|cell migration|protein ubiquitination|stem cell division|cell projection organization|cyclin binding|anaphase-promoting complex-dependent catabolic process|POZ domain binding|positive regulation of protein ubiquitination|cullin-RING ubiquitin ligase complex|Cul3-RING ubiquitin ligase complex|ubiquitin protein ligase binding|protein destabilization|positive regulation of cytokinesis|negative regulation of Rho protein signal transduction|sperm flagellum|embryonic cleavage|stress fiber assembly|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|fibroblast apoptotic process|positive regulation of mitotic metaphase/anaphase transition|COPII vesicle coating|protein autoubiquitination|ubiquitin protein ligase activity|extracellular exosome|nuclear protein quality control by the ubiquitin-proteasome system|liver morphogenesis|mitotic spindle|negative regulation of canonical Wnt signaling pathway|intrinsic apoptotic signaling pathway|positive regulation of mitotic cell cycle phase transition "hsa04120,hsa04340" Ubiquitin mediated proteolysis|Hedgehog signaling pathway CUL4A 2386.382008 2405.436897 2367.32712 0.984156817 -0.02303988 0.924158298 1 22.47833062 21.75201722 8451 cullin 4A "GO:0000082,GO:0000715,GO:0000717,GO:0001701,GO:0004842,GO:0005515,GO:0005654,GO:0006283,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006974,GO:0008284,GO:0016032,GO:0016567,GO:0019005,GO:0030097,GO:0030853,GO:0031146,GO:0031461,GO:0031464,GO:0031625,GO:0033683,GO:0035019,GO:0042254,GO:0042769,GO:0043161,GO:0043687,GO:0048511,GO:0051246,GO:0070911,GO:0080008,GO:0097193,GO:1900087,GO:2000001,GO:2000819" "G1/S transition of mitotic cell cycle|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|in utero embryonic development|ubiquitin-protein transferase activity|protein binding|nucleoplasm|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|cellular response to DNA damage stimulus|positive regulation of cell population proliferation|viral process|protein ubiquitination|SCF ubiquitin ligase complex|hemopoiesis|negative regulation of granulocyte differentiation|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cullin-RING ubiquitin ligase complex|Cul4A-RING E3 ubiquitin ligase complex|ubiquitin protein ligase binding|nucleotide-excision repair, DNA incision|somatic stem cell population maintenance|ribosome biogenesis|DNA damage response, detection of DNA damage|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|rhythmic process|regulation of protein metabolic process|global genome nucleotide-excision repair|Cul4-RING E3 ubiquitin ligase complex|intrinsic apoptotic signaling pathway|positive regulation of G1/S transition of mitotic cell cycle|regulation of DNA damage checkpoint|regulation of nucleotide-excision repair" "hsa03420,hsa04120,hsa05170" Nucleotide excision repair|Ubiquitin mediated proteolysis|Human immunodeficiency virus 1 infection CUL4B 4620.819544 4417.597346 4824.041743 1.092005759 0.126980465 0.595980163 1 37.28005236 40.02880463 8450 cullin 4B "GO:0000082,GO:0000715,GO:0000717,GO:0003684,GO:0004842,GO:0005515,GO:0005654,GO:0005829,GO:0006283,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006974,GO:0010498,GO:0016567,GO:0019005,GO:0031146,GO:0031461,GO:0031465,GO:0031625,GO:0033683,GO:0035518,GO:0042254,GO:0042769,GO:0043687,GO:0070062,GO:0070911,GO:0070914,GO:0080008" "G1/S transition of mitotic cell cycle|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|damaged DNA binding|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|cellular response to DNA damage stimulus|proteasomal protein catabolic process|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cullin-RING ubiquitin ligase complex|Cul4B-RING E3 ubiquitin ligase complex|ubiquitin protein ligase binding|nucleotide-excision repair, DNA incision|histone H2A monoubiquitination|ribosome biogenesis|DNA damage response, detection of DNA damage|post-translational protein modification|extracellular exosome|global genome nucleotide-excision repair|UV-damage excision repair|Cul4-RING E3 ubiquitin ligase complex" "hsa03420,hsa04120,hsa05170" Nucleotide excision repair|Ubiquitin mediated proteolysis|Human immunodeficiency virus 1 infection CUL5 1285.672697 1176.708101 1394.637292 1.185202422 0.24513348 0.309151422 1 9.244626625 10.77340743 8065 cullin 5 "GO:0000082,GO:0004842,GO:0005262,GO:0005515,GO:0005829,GO:0016032,GO:0016567,GO:0019005,GO:0031146,GO:0031461,GO:0031466,GO:0031625,GO:0038023,GO:0038128,GO:0043687,GO:0070588,GO:0090734,GO:0097193" G1/S transition of mitotic cell cycle|ubiquitin-protein transferase activity|calcium channel activity|protein binding|cytosol|viral process|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cullin-RING ubiquitin ligase complex|Cul5-RING ubiquitin ligase complex|ubiquitin protein ligase binding|signaling receptor activity|ERBB2 signaling pathway|post-translational protein modification|calcium ion transmembrane transport|site of DNA damage|intrinsic apoptotic signaling pathway "hsa04120,hsa05170" Ubiquitin mediated proteolysis|Human immunodeficiency virus 1 infection CUL7 953.1737153 925.9683556 980.3790751 1.058760884 0.082376801 0.741897126 1 8.769694637 9.129637588 9820 cullin 7 "GO:0000226,GO:0000281,GO:0001570,GO:0001837,GO:0001890,GO:0005515,GO:0005680,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0006508,GO:0006511,GO:0007030,GO:0007088,GO:0016032,GO:0016567,GO:0031461,GO:0031467,GO:0031625,GO:0036498,GO:0043687,GO:0048471,GO:0050775,GO:1990393" microtubule cytoskeleton organization|mitotic cytokinesis|vasculogenesis|epithelial to mesenchymal transition|placenta development|protein binding|anaphase-promoting complex|cytoplasm|Golgi apparatus|centrosome|cytosol|proteolysis|ubiquitin-dependent protein catabolic process|Golgi organization|regulation of mitotic nuclear division|viral process|protein ubiquitination|cullin-RING ubiquitin ligase complex|Cul7-RING ubiquitin ligase complex|ubiquitin protein ligase binding|IRE1-mediated unfolded protein response|post-translational protein modification|perinuclear region of cytoplasm|positive regulation of dendrite morphogenesis|3M complex hsa04120 Ubiquitin mediated proteolysis CUL9 510.1921032 550.3789439 470.0052625 0.853966649 -0.227748367 0.40419465 1 3.247397754 2.726764144 23113 cullin 9 "GO:0000226,GO:0005515,GO:0005524,GO:0005829,GO:0006511,GO:0007088,GO:0016567,GO:0016740,GO:0031461,GO:0031625,GO:0043687,GO:0046872" microtubule cytoskeleton organization|protein binding|ATP binding|cytosol|ubiquitin-dependent protein catabolic process|regulation of mitotic nuclear division|protein ubiquitination|transferase activity|cullin-RING ubiquitin ligase complex|ubiquitin protein ligase binding|post-translational protein modification|metal ion binding CUTA 1573.235122 1433.69033 1712.779914 1.194665178 0.256606339 0.281448287 1 68.437762 80.39206471 51596 cutA divalent cation tolerance homolog "GO:0005507,GO:0005515,GO:0008104,GO:0010038,GO:0016020,GO:0019899,GO:0070062" copper ion binding|protein binding|protein localization|response to metal ion|membrane|enzyme binding|extracellular exosome CUTC 838.5986261 819.8461395 857.3511127 1.045746356 0.064532971 0.800585999 1 32.84810935 33.77597669 51076 cutC copper transporter "GO:0005507,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006825,GO:0051262,GO:0055070" copper ion binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|copper ion transport|protein tetramerization|copper ion homeostasis CUX1 2196.995885 2202.55619 2191.43558 0.994951044 -0.007302555 0.977502486 1 7.336102834 7.176923234 1523 cut like homeobox 1 "GO:0000122,GO:0000139,GO:0000301,GO:0000785,GO:0000977,GO:0000981,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006357,GO:0007275,GO:0030674,GO:0043565,GO:0050775,GO:1990837" "negative regulation of transcription by RNA polymerase II|Golgi membrane|retrograde transport, vesicle recycling within Golgi|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|Golgi apparatus|cytosol|regulation of transcription by RNA polymerase II|multicellular organism development|protein-macromolecule adaptor activity|sequence-specific DNA binding|positive regulation of dendrite morphogenesis|sequence-specific double-stranded DNA binding" CUT CUZD1 9.96822023 9.363724944 10.57271552 1.129114277 0.175191507 0.976907777 1 0.255222058 0.283352654 50624 CUB and zona pellucida like domains 1 "GO:0007049,GO:0007155,GO:0016020,GO:0016021,GO:0030658,GO:0032023,GO:0042589,GO:0051301" cell cycle|cell adhesion|membrane|integral component of membrane|transport vesicle membrane|trypsinogen activation|zymogen granule membrane|cell division CWC15 755.3655155 653.3799183 857.3511127 1.312178548 0.391964041 0.122056818 1 19.95975122 25.75249052 51503 CWC15 spliceosome associated protein homolog "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005739,GO:0016607,GO:0045292,GO:0071007,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|mitochondrion|nuclear speck|mRNA cis splicing, via spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome CWC22 745.8722285 757.4213066 734.3231504 0.969504216 -0.044680922 0.865358891 1 10.92491434 10.41451191 57703 CWC22 spliceosome associated protein homolog "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005829,GO:0016607,GO:0048024,GO:0071005,GO:0071006,GO:0071007,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytosol|nuclear speck|regulation of mRNA splicing, via spliceosome|U2-type precatalytic spliceosome|U2-type catalytic step 1 spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" CWC25 420.047233 442.1759001 397.9185658 0.899910116 -0.152147183 0.598474755 1 7.694201208 6.808224244 54883 CWC25 spliceosome associated protein homolog "GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005684,GO:0016607,GO:0071006" "mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|U2-type spliceosomal complex|nuclear speck|U2-type catalytic step 1 spliceosome" CWC27 563.15003 515.0048719 611.295188 1.186969719 0.24728313 0.354390357 1 2.902002267 3.386948287 10283 CWC27 spliceosome associated cyclophilin "GO:0000398,GO:0000413,GO:0003755,GO:0005654,GO:0006457,GO:0016018,GO:0071005,GO:0071013" "mRNA splicing, via spliceosome|protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|nucleoplasm|protein folding|cyclosporin A binding|U2-type precatalytic spliceosome|catalytic step 2 spliceosome" CWF19L1 1461.983835 1427.447847 1496.519823 1.048388441 0.068173353 0.777695047 1 28.89994995 29.79137123 55280 CWF19 like cell cycle control factor 1 "GO:0000398,GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0050790,GO:0061632,GO:0071014" "mRNA splicing, via spliceosome|molecular_function|protein binding|cellular_component|biological_process|regulation of catalytic activity|RNA lariat debranching enzyme activator activity|post-mRNA release spliceosomal complex" CWF19L2 388.5228152 358.9427895 418.1028409 1.164817495 0.220103929 0.453236364 1 5.3019975 6.072514801 143884 CWF19 like cell cycle control factor 2 "GO:0000398,GO:0005515,GO:0071014" "mRNA splicing, via spliceosome|protein binding|post-mRNA release spliceosomal complex" CXCL1 12397.25345 11173.00469 13621.50221 1.219144052 0.285868603 0.265722365 1 507.9069208 608.8500323 2919 C-X-C motif chemokine ligand 1 "GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0006935,GO:0006954,GO:0007165,GO:0007186,GO:0007399,GO:0008009,GO:0008047,GO:0008083,GO:0008285,GO:0019221,GO:0030036,GO:0030593,GO:0035556,GO:0035580,GO:0043312,GO:0045236,GO:0050790,GO:0061844,GO:0070098,GO:0071222,GO:1904724" signaling receptor binding|protein binding|extracellular region|extracellular space|chemotaxis|inflammatory response|signal transduction|G protein-coupled receptor signaling pathway|nervous system development|chemokine activity|enzyme activator activity|growth factor activity|negative regulation of cell population proliferation|cytokine-mediated signaling pathway|actin cytoskeleton organization|neutrophil chemotaxis|intracellular signal transduction|specific granule lumen|neutrophil degranulation|CXCR chemokine receptor binding|regulation of catalytic activity|antimicrobial humoral immune response mediated by antimicrobial peptide|chemokine-mediated signaling pathway|cellular response to lipopolysaccharide|tertiary granule lumen "hsa04060,hsa04061,hsa04062,hsa04064,hsa04621,hsa04657,hsa04668,hsa05120,hsa05134,hsa05146,hsa05167,hsa05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|NF-kappa B signaling pathway|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Epithelial cell signaling in Helicobacter pylori infection|Legionellosis|Amoebiasis|Kaposi sarcoma-associated herpesvirus infection|Rheumatoid arthritis CXCL16 68.73712773 63.46524684 74.00900861 1.166134417 0.221734093 0.697256974 1 1.412436856 1.619529388 58191 C-X-C motif chemokine ligand 16 "GO:0005041,GO:0005044,GO:0005576,GO:0005615,GO:0005886,GO:0006898,GO:0006935,GO:0007186,GO:0008009,GO:0010818,GO:0016020,GO:0016021,GO:0030307,GO:0030335,GO:0034097,GO:0034341,GO:0034612" low-density lipoprotein particle receptor activity|scavenger receptor activity|extracellular region|extracellular space|plasma membrane|receptor-mediated endocytosis|chemotaxis|G protein-coupled receptor signaling pathway|chemokine activity|T cell chemotaxis|membrane|integral component of membrane|positive regulation of cell growth|positive regulation of cell migration|response to cytokine|response to interferon-gamma|response to tumor necrosis factor "hsa04060,hsa04062" Cytokine-cytokine receptor interaction|Chemokine signaling pathway CXCL2 2335.070834 2130.767632 2539.374036 1.191764882 0.253099641 0.284391245 1 101.9866837 119.5102714 2920 C-X-C motif chemokine ligand 2 "GO:0002237,GO:0005515,GO:0005576,GO:0005615,GO:0006935,GO:0006954,GO:0007186,GO:0008009,GO:0019221,GO:0030593,GO:0045236,GO:0061844,GO:0070098,GO:0071222" response to molecule of bacterial origin|protein binding|extracellular region|extracellular space|chemotaxis|inflammatory response|G protein-coupled receptor signaling pathway|chemokine activity|cytokine-mediated signaling pathway|neutrophil chemotaxis|CXCR chemokine receptor binding|antimicrobial humoral immune response mediated by antimicrobial peptide|chemokine-mediated signaling pathway|cellular response to lipopolysaccharide "hsa04060,hsa04061,hsa04062,hsa04064,hsa04621,hsa04657,hsa04668,hsa05120,hsa05134,hsa05146,hsa05167,hsa05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|NF-kappa B signaling pathway|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Epithelial cell signaling in Helicobacter pylori infection|Legionellosis|Amoebiasis|Kaposi sarcoma-associated herpesvirus infection|Rheumatoid arthritis CXCL3 722.1314075 638.8141239 805.4486911 1.260849848 0.334396478 0.190013002 1 31.71380066 39.31722348 2921 C-X-C motif chemokine ligand 3 "GO:0005576,GO:0005615,GO:0006954,GO:0007186,GO:0008009,GO:0030593,GO:0045236,GO:0061844,GO:0070098,GO:0071222" extracellular region|extracellular space|inflammatory response|G protein-coupled receptor signaling pathway|chemokine activity|neutrophil chemotaxis|CXCR chemokine receptor binding|antimicrobial humoral immune response mediated by antimicrobial peptide|chemokine-mediated signaling pathway|cellular response to lipopolysaccharide "hsa04060,hsa04061,hsa04062,hsa04064,hsa04621,hsa04657,hsa04668,hsa05120,hsa05134,hsa05146,hsa05167,hsa05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|NF-kappa B signaling pathway|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Epithelial cell signaling in Helicobacter pylori infection|Legionellosis|Amoebiasis|Kaposi sarcoma-associated herpesvirus infection|Rheumatoid arthritis CXCL5 4107.408548 2811.198311 5403.618785 1.922176306 0.942740669 8.67E-05 0.032934316 61.58804889 116.4021076 6374 C-X-C motif chemokine ligand 5 "GO:0005515,GO:0005576,GO:0005615,GO:0006935,GO:0006954,GO:0007165,GO:0007186,GO:0007267,GO:0008009,GO:0008284,GO:0030593,GO:0042802,GO:0045236,GO:0061844,GO:0070098,GO:0071222" protein binding|extracellular region|extracellular space|chemotaxis|inflammatory response|signal transduction|G protein-coupled receptor signaling pathway|cell-cell signaling|chemokine activity|positive regulation of cell population proliferation|neutrophil chemotaxis|identical protein binding|CXCR chemokine receptor binding|antimicrobial humoral immune response mediated by antimicrobial peptide|chemokine-mediated signaling pathway|cellular response to lipopolysaccharide "hsa04060,hsa04061,hsa04062,hsa04657,hsa04668,hsa05133,hsa05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Pertussis|Rheumatoid arthritis CXCL6 243.4530469 297.5583704 189.3477233 0.636338084 -0.652134627 0.053543825 1 10.33190848 6.464570042 6372 C-X-C motif chemokine ligand 6 "GO:0001776,GO:0005515,GO:0005576,GO:0005615,GO:0006935,GO:0006954,GO:0007165,GO:0007186,GO:0007267,GO:0008009,GO:0008201,GO:0030593,GO:0032642,GO:0042119,GO:0042742,GO:0045236,GO:0061844,GO:0070098,GO:0070951,GO:0071222" leukocyte homeostasis|protein binding|extracellular region|extracellular space|chemotaxis|inflammatory response|signal transduction|G protein-coupled receptor signaling pathway|cell-cell signaling|chemokine activity|heparin binding|neutrophil chemotaxis|regulation of chemokine production|neutrophil activation|defense response to bacterium|CXCR chemokine receptor binding|antimicrobial humoral immune response mediated by antimicrobial peptide|chemokine-mediated signaling pathway|regulation of neutrophil mediated killing of gram-negative bacterium|cellular response to lipopolysaccharide "hsa04060,hsa04061,hsa04062,hsa04657,hsa04668,hsa05133,hsa05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Pertussis|Rheumatoid arthritis CXCL8 37239.32178 28787.21172 45691.43184 1.587212832 0.666495594 0.030130174 0.895820653 935.6398178 1460.209065 3576 C-X-C motif chemokine ligand 8 "GO:0001525,GO:0002237,GO:0005153,GO:0005515,GO:0005576,GO:0005615,GO:0006935,GO:0006954,GO:0007050,GO:0007165,GO:0007186,GO:0008009,GO:0008285,GO:0010628,GO:0010629,GO:0019221,GO:0019722,GO:0030155,GO:0030593,GO:0031328,GO:0031623,GO:0034976,GO:0035556,GO:0036499,GO:0042119,GO:0044344,GO:0045091,GO:0045236,GO:0045744,GO:0045766,GO:0048566,GO:0050930,GO:0060354,GO:0061844,GO:0070098,GO:0071222,GO:0071347,GO:0071356,GO:0090023,GO:2000535" angiogenesis|response to molecule of bacterial origin|interleukin-8 receptor binding|protein binding|extracellular region|extracellular space|chemotaxis|inflammatory response|cell cycle arrest|signal transduction|G protein-coupled receptor signaling pathway|chemokine activity|negative regulation of cell population proliferation|positive regulation of gene expression|negative regulation of gene expression|cytokine-mediated signaling pathway|calcium-mediated signaling|regulation of cell adhesion|neutrophil chemotaxis|positive regulation of cellular biosynthetic process|receptor internalization|response to endoplasmic reticulum stress|intracellular signal transduction|PERK-mediated unfolded protein response|neutrophil activation|cellular response to fibroblast growth factor stimulus|regulation of single stranded viral RNA replication via double stranded DNA intermediate|CXCR chemokine receptor binding|negative regulation of G protein-coupled receptor signaling pathway|positive regulation of angiogenesis|embryonic digestive tract development|induction of positive chemotaxis|negative regulation of cell adhesion molecule production|antimicrobial humoral immune response mediated by antimicrobial peptide|chemokine-mediated signaling pathway|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to tumor necrosis factor|positive regulation of neutrophil chemotaxis|regulation of entry of bacterium into host cell "hsa04060,hsa04061,hsa04062,hsa04064,hsa04072,hsa04218,hsa04620,hsa04621,hsa04622,hsa04657,hsa04932,hsa04933,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05134,hsa05135,hsa05142,hsa05144,hsa05146,hsa05161,hsa05163,hsa05164,hsa05167,hsa05171,hsa05200,hsa05202,hsa05219,hsa05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|NF-kappa B signaling pathway|Phospholipase D signaling pathway|Cellular senescence|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Chagas disease|Malaria|Amoebiasis|Hepatitis B|Human cytomegalovirus infection|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Coronavirus disease - COVID-19|Pathways in cancer|Transcriptional misregulation in cancer|Bladder cancer|Rheumatoid arthritis CXXC1 1197.801154 1191.273896 1204.328413 1.010958452 0.015723706 0.951971055 1 26.24942128 26.09301229 30827 CXXC finger protein 1 "GO:0000987,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0008270,GO:0016363,GO:0016607,GO:0035064,GO:0035097,GO:0036498,GO:0042800,GO:0045322,GO:0045893,GO:0048188,GO:0051568" "cis-regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|zinc ion binding|nuclear matrix|nuclear speck|methylated histone binding|histone methyltransferase complex|IRE1-mediated unfolded protein response|histone methyltransferase activity (H3-K4 specific)|unmethylated CpG binding|positive regulation of transcription, DNA-templated|Set1C/COMPASS complex|histone H3-K4 methylation" CXXC4 47.67598504 53.06110801 42.29086206 0.797021842 -0.327308833 0.610188123 1 0.492225589 0.385749693 80319 CXXC finger protein 4 "GO:0005634,GO:0005737,GO:0007352,GO:0008270,GO:0008327,GO:0016055,GO:0030165,GO:0030178,GO:0031410" nucleus|cytoplasm|zygotic specification of dorsal/ventral axis|zinc ion binding|methyl-CpG binding|Wnt signaling pathway|PDZ domain binding|negative regulation of Wnt signaling pathway|cytoplasmic vesicle hsa04310 Wnt signaling pathway CXXC5 81.42526955 81.15228285 81.69825626 1.006727764 0.009673607 1 1 1.214852226 1.20255979 51523 CXXC finger protein 5 "GO:0000122,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0008134,GO:0008270,GO:0008327,GO:0043123,GO:0043565" negative regulation of transcription by RNA polymerase II|protein binding|nucleus|nucleoplasm|cytosol|transcription factor binding|zinc ion binding|methyl-CpG binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|sequence-specific DNA binding CXorf38 1554.676863 1274.507006 1834.84672 1.439652125 0.525720244 0.027513967 0.877967194 12.56801487 17.79079794 159013 chromosome X open reading frame 38 GO:0005515 protein binding CXorf58 3.562190663 5.202069413 1.922311912 0.369528309 -1.436243205 0.543489417 1 0.16990507 0.061734115 254158 chromosome X open reading frame 58 CYB561 588.0897806 639.8545378 536.3250234 0.838198359 -0.254636398 0.335655865 1 9.019508896 7.43362889 1534 cytochrome b561 "GO:0000293,GO:0005515,GO:0005765,GO:0016021,GO:0016491,GO:0022900,GO:0030658,GO:0046872" ferric-chelate reductase activity|protein binding|lysosomal membrane|integral component of membrane|oxidoreductase activity|electron transport chain|transport vesicle membrane|metal ion binding CYB561A3 487.253308 528.5302524 445.9763636 0.843804799 -0.245018802 0.374350134 1 7.800522172 6.471975215 220002 cytochrome b561 family member A3 "GO:0005515,GO:0005730,GO:0005765,GO:0016021,GO:0016491,GO:0031902,GO:0043231,GO:0046872,GO:0055114" protein binding|nucleolus|lysosomal membrane|integral component of membrane|oxidoreductase activity|late endosome membrane|intracellular membrane-bounded organelle|metal ion binding|oxidation-reduction process CYB561D1 330.253993 355.8215479 304.686438 0.856290014 -0.223828595 0.467146573 1 3.387360335 2.852025836 284613 cytochrome b561 family member D1 "GO:0005515,GO:0016021,GO:0016491,GO:0020037,GO:0046872,GO:0055114" protein binding|integral component of membrane|oxidoreductase activity|heme binding|metal ion binding|oxidation-reduction process CYB561D2 275.7958104 238.2547791 313.3368417 1.3151335 0.395209256 0.223771168 1 10.5258441 13.61124817 11068 cytochrome b561 family member D2 "GO:0004322,GO:0005515,GO:0005783,GO:0005789,GO:0016021,GO:0016491,GO:0020037,GO:0030659,GO:0031982,GO:0046872,GO:0055114" ferroxidase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|oxidoreductase activity|heme binding|cytoplasmic vesicle membrane|vesicle|metal ion binding|oxidation-reduction process CYB5A 494.0562416 442.1759001 545.936583 1.23465929 0.304112979 0.267933793 1 5.668535937 6.881596613 1528 cytochrome b5 type A "GO:0004129,GO:0005515,GO:0005741,GO:0005789,GO:0005829,GO:0009055,GO:0016020,GO:0016021,GO:0019852,GO:0019899,GO:0020037,GO:0022900,GO:0043231,GO:0046686,GO:0046872,GO:1902600" cytochrome-c oxidase activity|protein binding|mitochondrial outer membrane|endoplasmic reticulum membrane|cytosol|electron transfer activity|membrane|integral component of membrane|L-ascorbic acid metabolic process|enzyme binding|heme binding|electron transport chain|intracellular membrane-bounded organelle|response to cadmium ion|metal ion binding|proton transmembrane transport CYB5B 2541.46024 2376.305308 2706.615172 1.139001442 0.187769573 0.42735375 1 29.75575946 33.32471867 80777 cytochrome b5 type B "GO:0005515,GO:0005741,GO:0006805,GO:0006809,GO:0008047,GO:0009055,GO:0016020,GO:0016021,GO:0020037,GO:0022900,GO:0043231,GO:0046872,GO:0050421,GO:0050790,GO:1903958" protein binding|mitochondrial outer membrane|xenobiotic metabolic process|nitric oxide biosynthetic process|enzyme activator activity|electron transfer activity|membrane|integral component of membrane|heme binding|electron transport chain|intracellular membrane-bounded organelle|metal ion binding|nitrite reductase (NO-forming) activity|regulation of catalytic activity|nitric-oxide synthase complex CYB5D1 405.1889446 443.216314 367.1615752 0.828402664 -0.271595902 0.347384172 1 6.779489849 5.522168828 124637 cytochrome b5 domain containing 1 GO:0046872 metal ion binding CYB5D2 161.4088052 162.3045657 160.5130447 0.98896198 -0.016013036 0.98538479 1 2.357620133 2.292580562 124936 cytochrome b5 domain containing 2 "GO:0005515,GO:0005576,GO:0007399,GO:0012505,GO:0016020,GO:0020037,GO:0045666" protein binding|extracellular region|nervous system development|endomembrane system|membrane|heme binding|positive regulation of neuron differentiation CYB5R1 566.761296 597.1975686 536.3250234 0.89806967 -0.155100725 0.562884637 1 19.62520729 17.32987622 51706 cytochrome b5 reductase 1 "GO:0002576,GO:0004128,GO:0005515,GO:0005739,GO:0005789,GO:0005886,GO:0015701,GO:0016020,GO:0016021,GO:0016126,GO:0031092,GO:0055114,GO:0070062,GO:0071949" "platelet degranulation|cytochrome-b5 reductase activity, acting on NAD(P)H|protein binding|mitochondrion|endoplasmic reticulum membrane|plasma membrane|bicarbonate transport|membrane|integral component of membrane|sterol biosynthetic process|platelet alpha granule membrane|oxidation-reduction process|extracellular exosome|FAD binding" hsa00520 Amino sugar and nucleotide sugar metabolism CYB5R2 44.39119712 55.14193578 33.64045846 0.610070321 -0.712952548 0.257785182 1 1.124073249 0.674288401 51700 cytochrome b5 reductase 2 "GO:0004128,GO:0005515,GO:0005634,GO:0005789,GO:0015701,GO:0016020,GO:0016126,GO:0055114,GO:0071949" "cytochrome-b5 reductase activity, acting on NAD(P)H|protein binding|nucleus|endoplasmic reticulum membrane|bicarbonate transport|membrane|sterol biosynthetic process|oxidation-reduction process|FAD binding" hsa00520 Amino sugar and nucleotide sugar metabolism CYB5R3 5489.880094 4876.419868 6103.340321 1.25160271 0.323776687 0.179400397 1 74.31341116 91.45445588 1727 cytochrome b5 reductase 3 "GO:0004128,GO:0005515,GO:0005576,GO:0005737,GO:0005739,GO:0005741,GO:0005783,GO:0005789,GO:0005811,GO:0005833,GO:0006695,GO:0006805,GO:0006809,GO:0008015,GO:0016020,GO:0016208,GO:0019852,GO:0035578,GO:0043312,GO:0043531,GO:0050421,GO:0051287,GO:0055114,GO:0071949,GO:1903958" "cytochrome-b5 reductase activity, acting on NAD(P)H|protein binding|extracellular region|cytoplasm|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|hemoglobin complex|cholesterol biosynthetic process|xenobiotic metabolic process|nitric oxide biosynthetic process|blood circulation|membrane|AMP binding|L-ascorbic acid metabolic process|azurophil granule lumen|neutrophil degranulation|ADP binding|nitrite reductase (NO-forming) activity|NAD binding|oxidation-reduction process|FAD binding|nitric-oxide synthase complex" hsa00520 Amino sugar and nucleotide sugar metabolism CYB5R4 654.8309833 587.8338437 721.828123 1.22794584 0.29624693 0.25304839 1 3.408105578 4.114939277 51167 cytochrome b5 reductase 4 "GO:0003032,GO:0004128,GO:0005783,GO:0005789,GO:0006091,GO:0006801,GO:0015701,GO:0016174,GO:0016653,GO:0020037,GO:0030073,GO:0042593,GO:0046677,GO:0046872,GO:0048468,GO:0048471,GO:0055114" "detection of oxygen|cytochrome-b5 reductase activity, acting on NAD(P)H|endoplasmic reticulum|endoplasmic reticulum membrane|generation of precursor metabolites and energy|superoxide metabolic process|bicarbonate transport|NAD(P)H oxidase H2O2-forming activity|oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor|heme binding|insulin secretion|glucose homeostasis|response to antibiotic|metal ion binding|cell development|perinuclear region of cytoplasm|oxidation-reduction process" hsa00520 Amino sugar and nucleotide sugar metabolism CYB5RL 376.3989253 431.7717613 321.0260893 0.743508766 -0.427578344 0.145846345 1 3.606082212 2.636288258 606495 cytochrome b5 reductase like "GO:0004128,GO:0005654,GO:0005789,GO:0015701,GO:0055114" "cytochrome-b5 reductase activity, acting on NAD(P)H|nucleoplasm|endoplasmic reticulum membrane|bicarbonate transport|oxidation-reduction process" hsa00520 Amino sugar and nucleotide sugar metabolism CYBA 4760.631909 4605.912258 4915.351559 1.067183065 0.093807677 0.6958387 1 95.86937283 100.5981489 1535 cytochrome b-245 alpha chain "GO:0002479,GO:0005515,GO:0005789,GO:0005886,GO:0006801,GO:0006954,GO:0009055,GO:0014895,GO:0016020,GO:0016175,GO:0017004,GO:0017124,GO:0020037,GO:0022900,GO:0030141,GO:0030670,GO:0032755,GO:0032760,GO:0034137,GO:0034599,GO:0035579,GO:0042554,GO:0043020,GO:0043312,GO:0045087,GO:0045454,GO:0045730,GO:0046872,GO:0046982,GO:0048010,GO:0050665,GO:0050766,GO:0055114,GO:0070821,GO:1900426,GO:1903428" "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|endoplasmic reticulum membrane|plasma membrane|superoxide metabolic process|inflammatory response|electron transfer activity|smooth muscle hypertrophy|membrane|superoxide-generating NAD(P)H oxidase activity|cytochrome complex assembly|SH3 domain binding|heme binding|electron transport chain|secretory granule|phagocytic vesicle membrane|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of toll-like receptor 2 signaling pathway|cellular response to oxidative stress|specific granule membrane|superoxide anion generation|NADPH oxidase complex|neutrophil degranulation|innate immune response|cell redox homeostasis|respiratory burst|metal ion binding|protein heterodimerization activity|vascular endothelial growth factor receptor signaling pathway|hydrogen peroxide biosynthetic process|positive regulation of phagocytosis|oxidation-reduction process|tertiary granule membrane|positive regulation of defense response to bacterium|positive regulation of reactive oxygen species biosynthetic process" "hsa04145,hsa04380,hsa04621,hsa04670,hsa05020,hsa05140,hsa05418" Phagosome|Osteoclast differentiation|NOD-like receptor signaling pathway|Leukocyte transendothelial migration|Prion disease|Leishmaniasis|Fluid shear stress and atherosclerosis CYBC1 827.2333314 799.0378619 855.4288008 1.070573551 0.098383915 0.698004205 1 17.11203135 18.01313299 79415 cytochrome b-245 chaperone 1 "GO:0005515,GO:0005783,GO:0005789,GO:0016021,GO:0045087,GO:0045728" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|innate immune response|respiratory burst after phagocytosis CYBRD1 3329.128276 3070.261368 3587.995184 1.16862858 0.224816478 0.343187699 1 38.15887431 43.84733843 79901 cytochrome b reductase 1 "GO:0000293,GO:0005515,GO:0005765,GO:0005886,GO:0006879,GO:0010039,GO:0016021,GO:0016491,GO:0031526,GO:0046872,GO:0055114,GO:0070062" ferric-chelate reductase activity|protein binding|lysosomal membrane|plasma membrane|cellular iron ion homeostasis|response to iron ion|integral component of membrane|oxidoreductase activity|brush border membrane|metal ion binding|oxidation-reduction process|extracellular exosome hsa04978 Mineral absorption CYC1 2430.902767 2337.809994 2523.99554 1.079641009 0.110551682 0.640898845 1 69.50675358 73.78660959 1537 cytochrome c1 "GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005750,GO:0006122,GO:0016020,GO:0016021,GO:0020037,GO:0033762,GO:0045153,GO:0045155,GO:0046872" "protein binding|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex III|mitochondrial electron transport, ubiquinol to cytochrome c|membrane|integral component of membrane|heme binding|response to glucagon|electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity|electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|metal ion binding" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases CYCS 2817.493824 2620.80257 3014.185078 1.150100016 0.201759327 0.393959863 1 25.74878799 29.11813662 54205 "cytochrome c, somatic" "GO:0000159,GO:0004722,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005758,GO:0005829,GO:0006122,GO:0006123,GO:0006470,GO:0006915,GO:0007005,GO:0008635,GO:0020037,GO:0034599,GO:0043280,GO:0045155,GO:0045333,GO:0046872,GO:0070469" "protein phosphatase type 2A complex|protein serine/threonine phosphatase activity|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|cytosol|mitochondrial electron transport, ubiquinol to cytochrome c|mitochondrial electron transport, cytochrome c to oxygen|protein dephosphorylation|apoptotic process|mitochondrion organization|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|heme binding|cellular response to oxidative stress|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|cellular respiration|metal ion binding|respirasome" "hsa01524,hsa04115,hsa04210,hsa04215,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05130,hsa05131,hsa05132,hsa05134,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05210,hsa05222,hsa05416" Platinum drug resistance|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Legionellosis|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Colorectal cancer|Small cell lung cancer|Viral myocarditis CYFIP1 2620.481391 2659.297884 2581.664898 0.970806961 -0.042743641 0.857985206 1 17.8316171 17.0213809 23191 cytoplasmic FMR1 interacting protein 1 "GO:0000340,GO:0000902,GO:0001726,GO:0005515,GO:0005576,GO:0005829,GO:0005845,GO:0005925,GO:0006417,GO:0007411,GO:0008360,GO:0010592,GO:0016601,GO:0030027,GO:0030031,GO:0030032,GO:0031209,GO:0031267,GO:0031529,GO:0031641,GO:0032433,GO:0032869,GO:0034774,GO:0035580,GO:0038096,GO:0043005,GO:0043025,GO:0043195,GO:0043197,GO:0043312,GO:0044294,GO:0044295,GO:0045182,GO:0045202,GO:0045773,GO:0048010,GO:0048471,GO:0048675,GO:0050890,GO:0051015,GO:0051388,GO:0051602,GO:0060076,GO:0070062,GO:0090724,GO:0090725,GO:0097484,GO:0099563,GO:0099578,GO:1900006,GO:1900029,GO:1903422,GO:1904724,GO:1905274,GO:2000601" "RNA 7-methylguanosine cap binding|cell morphogenesis|ruffle|protein binding|extracellular region|cytosol|mRNA cap binding complex|focal adhesion|regulation of translation|axon guidance|regulation of cell shape|positive regulation of lamellipodium assembly|Rac protein signal transduction|lamellipodium|cell projection assembly|lamellipodium assembly|SCAR complex|small GTPase binding|ruffle organization|regulation of myelination|filopodium tip|cellular response to insulin stimulus|secretory granule lumen|specific granule lumen|Fc-gamma receptor signaling pathway involved in phagocytosis|neuron projection|neuronal cell body|terminal bouton|dendritic spine|neutrophil degranulation|dendritic growth cone|axonal growth cone|translation regulator activity|synapse|positive regulation of axon extension|vascular endothelial growth factor receptor signaling pathway|perinuclear region of cytoplasm|axon extension|cognition|actin filament binding|positive regulation of neurotrophin TRK receptor signaling pathway|response to electrical stimulus|excitatory synapse|extracellular exosome|central region of growth cone|peripheral region of growth cone|dendrite extension|modification of synaptic structure|regulation of translation at postsynapse, modulating synaptic transmission|positive regulation of dendrite development|positive regulation of ruffle assembly|negative regulation of synaptic vesicle recycling|tertiary granule lumen|regulation of modification of postsynaptic actin cytoskeleton|positive regulation of Arp2/3 complex-mediated actin nucleation" "hsa03013,hsa04810,hsa05130,hsa05132" RNA transport|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Salmonella infection CYFIP2 416.3265264 432.8121752 399.8408777 0.923820772 -0.11431511 0.695302748 1 3.221532819 2.926317615 26999 cytoplasmic FMR1 interacting protein 2 "GO:0000340,GO:0000902,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0016020,GO:0030833,GO:0031209,GO:0038096,GO:0043005,GO:0045202,GO:0045862,GO:0048010,GO:0048471,GO:0070062,GO:0097202,GO:0098609" RNA 7-methylguanosine cap binding|cell morphogenesis|protein binding|nucleus|cytoplasm|cytosol|apoptotic process|membrane|regulation of actin filament polymerization|SCAR complex|Fc-gamma receptor signaling pathway involved in phagocytosis|neuron projection|synapse|positive regulation of proteolysis|vascular endothelial growth factor receptor signaling pathway|perinuclear region of cytoplasm|extracellular exosome|activation of cysteine-type endopeptidase activity|cell-cell adhesion "hsa03013,hsa04810,hsa05130,hsa05132" RNA transport|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Salmonella infection CYGB 23.14197045 14.56579436 31.71814655 2.177577533 1.122724087 0.167087927 1 0.206302992 0.441723325 114757 cytoglobin "GO:0004601,GO:0005344,GO:0005506,GO:0005515,GO:0005829,GO:0006979,GO:0015671,GO:0019825,GO:0020037,GO:0050999,GO:0098869" peroxidase activity|oxygen carrier activity|iron ion binding|protein binding|cytosol|response to oxidative stress|oxygen transport|oxygen binding|heme binding|regulation of nitric-oxide synthase activity|cellular oxidant detoxification CYHR1 683.4970853 608.6421213 758.3520493 1.245973656 0.317273566 0.217572944 1 9.08336448 11.12824759 50626 cysteine and histidine rich 1 "GO:0005515,GO:0005654,GO:0008270,GO:0048471" protein binding|nucleoplasm|zinc ion binding|perinuclear region of cytoplasm CYLD 1617.908752 1483.630197 1752.187308 1.181013511 0.24002547 0.313231985 1 8.739361678 10.14859117 1540 CYLD lysine 63 deubiquitinase "GO:0004843,GO:0005515,GO:0005813,GO:0005819,GO:0005829,GO:0005881,GO:0006511,GO:0007049,GO:0007346,GO:0008234,GO:0008270,GO:0010803,GO:0016055,GO:0016579,GO:0018215,GO:0019901,GO:0030496,GO:0031234,GO:0032088,GO:0032480,GO:0036064,GO:0045087,GO:0046329,GO:0048471,GO:0050727,GO:0060544,GO:0061578,GO:0070064,GO:0070266,GO:0070423,GO:0070507,GO:0070536,GO:0090090,GO:0097542,GO:1901223,GO:1902017,GO:1903753,GO:1990108,GO:2001238,GO:2001242" thiol-dependent ubiquitin-specific protease activity|protein binding|centrosome|spindle|cytosol|cytoplasmic microtubule|ubiquitin-dependent protein catabolic process|cell cycle|regulation of mitotic cell cycle|cysteine-type peptidase activity|zinc ion binding|regulation of tumor necrosis factor-mediated signaling pathway|Wnt signaling pathway|protein deubiquitination|protein phosphopantetheinylation|protein kinase binding|midbody|extrinsic component of cytoplasmic side of plasma membrane|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|ciliary basal body|innate immune response|negative regulation of JNK cascade|perinuclear region of cytoplasm|regulation of inflammatory response|regulation of necroptotic process|Lys63-specific deubiquitinase activity|proline-rich region binding|necroptotic process|nucleotide-binding oligomerization domain containing signaling pathway|regulation of microtubule cytoskeleton organization|protein K63-linked deubiquitination|negative regulation of canonical Wnt signaling pathway|ciliary tip|negative regulation of NIK/NF-kappaB signaling|regulation of cilium assembly|negative regulation of p38MAPK cascade|protein linear deubiquitination|positive regulation of extrinsic apoptotic signaling pathway|regulation of intrinsic apoptotic signaling pathway "hsa04064,hsa04217,hsa04380,hsa04622,hsa04625" NF-kappa B signaling pathway|Necroptosis|Osteoclast differentiation|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway CYP1A1 14.44690747 26.01034707 2.883467868 0.110858493 -3.173208799 0.004086328 0.390726074 0.533278685 0.058129204 1543 cytochrome P450 family 1 subfamily A member 1 "GO:0001666,GO:0002933,GO:0004497,GO:0005506,GO:0005515,GO:0005743,GO:0005789,GO:0006306,GO:0006631,GO:0006694,GO:0006778,GO:0007568,GO:0008202,GO:0008210,GO:0008283,GO:0008391,GO:0009308,GO:0009611,GO:0009615,GO:0009624,GO:0009635,GO:0009692,GO:0009804,GO:0009812,GO:0010041,GO:0016491,GO:0016679,GO:0016711,GO:0017143,GO:0017144,GO:0019216,GO:0019341,GO:0019373,GO:0019825,GO:0019899,GO:0020037,GO:0030544,GO:0032094,GO:0032451,GO:0032496,GO:0033189,GO:0035902,GO:0042359,GO:0042493,GO:0042572,GO:0042759,GO:0042904,GO:0043010,GO:0043231,GO:0046677,GO:0046685,GO:0048565,GO:0050665,GO:0051879,GO:0055093,GO:0055114,GO:0060137,GO:0070330,GO:0070365,GO:0070576,GO:0070988,GO:0071280,GO:0071407,GO:0097267,GO:0101020,GO:0101021,GO:0106256,GO:1900087" "response to hypoxia|lipid hydroxylation|monooxygenase activity|iron ion binding|protein binding|mitochondrial inner membrane|endoplasmic reticulum membrane|DNA methylation|fatty acid metabolic process|steroid biosynthetic process|porphyrin-containing compound metabolic process|aging|steroid metabolic process|estrogen metabolic process|cell population proliferation|arachidonic acid monooxygenase activity|amine metabolic process|response to wounding|response to virus|response to nematode|response to herbicide|ethylene metabolic process|coumarin metabolic process|flavonoid metabolic process|response to iron(III) ion|oxidoreductase activity|oxidoreductase activity, acting on diphenols and related substances as donors|flavonoid 3'-monooxygenase activity|insecticide metabolic process|drug metabolic process|regulation of lipid metabolic process|dibenzo-p-dioxin catabolic process|epoxygenase P450 pathway|oxygen binding|enzyme binding|heme binding|Hsp70 protein binding|response to food|demethylase activity|response to lipopolysaccharide|response to vitamin A|response to immobilization stress|vitamin D metabolic process|response to drug|retinol metabolic process|long-chain fatty acid biosynthetic process|9-cis-retinoic acid biosynthetic process|camera-type eye development|intracellular membrane-bounded organelle|response to antibiotic|response to arsenic-containing substance|digestive tract development|hydrogen peroxide biosynthetic process|Hsp90 protein binding|response to hyperoxia|oxidation-reduction process|maternal process involved in parturition|aromatase activity|hepatocyte differentiation|vitamin D 24-hydroxylase activity|demethylation|cellular response to copper ion|cellular response to organic cyclic compound|omega-hydroxylase P450 pathway|estrogen 16-alpha-hydroxylase activity|estrogen 2-hydroxylase activity|hydroperoxy icosatetraenoate dehydratase activity|positive regulation of G1/S transition of mitotic cell cycle" "hsa00140,hsa00380,hsa00830,hsa00980,hsa04913,hsa05204" Steroid hormone biosynthesis|Tryptophan metabolism|Retinol metabolism|Metabolism of xenobiotics by cytochrome P450|Ovarian steroidogenesis|Chemical carcinogenesis CYP1B1 5.603389465 8.323311061 2.883467868 0.346432789 -1.529352609 0.352439314 1 0.085128366 0.028997761 1545 cytochrome P450 family 1 subfamily B member 1 "GO:0001525,GO:0002930,GO:0004497,GO:0005506,GO:0005739,GO:0005789,GO:0006725,GO:0006805,GO:0006809,GO:0007155,GO:0007601,GO:0008202,GO:0008210,GO:0008285,GO:0008631,GO:0009404,GO:0009636,GO:0010575,GO:0016125,GO:0016712,GO:0019369,GO:0019373,GO:0019825,GO:0020037,GO:0030199,GO:0030336,GO:0032088,GO:0033629,GO:0042572,GO:0042574,GO:0043065,GO:0043231,GO:0043542,GO:0045766,GO:0046427,GO:0046466,GO:0048514,GO:0055114,GO:0061304,GO:0070301,GO:0070330,GO:0071407,GO:0071603,GO:0097267,GO:0101020,GO:0106256,GO:2000377" "angiogenesis|trabecular meshwork development|monooxygenase activity|iron ion binding|mitochondrion|endoplasmic reticulum membrane|cellular aromatic compound metabolic process|xenobiotic metabolic process|nitric oxide biosynthetic process|cell adhesion|visual perception|steroid metabolic process|estrogen metabolic process|negative regulation of cell population proliferation|intrinsic apoptotic signaling pathway in response to oxidative stress|toxin metabolic process|response to toxic substance|positive regulation of vascular endothelial growth factor production|sterol metabolic process|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|arachidonic acid metabolic process|epoxygenase P450 pathway|oxygen binding|heme binding|collagen fibril organization|negative regulation of cell migration|negative regulation of NF-kappaB transcription factor activity|negative regulation of cell adhesion mediated by integrin|retinol metabolic process|retinal metabolic process|positive regulation of apoptotic process|intracellular membrane-bounded organelle|endothelial cell migration|positive regulation of angiogenesis|positive regulation of receptor signaling pathway via JAK-STAT|membrane lipid catabolic process|blood vessel morphogenesis|oxidation-reduction process|retinal blood vessel morphogenesis|cellular response to hydrogen peroxide|aromatase activity|cellular response to organic cyclic compound|endothelial cell-cell adhesion|omega-hydroxylase P450 pathway|estrogen 16-alpha-hydroxylase activity|hydroperoxy icosatetraenoate dehydratase activity|regulation of reactive oxygen species metabolic process" "hsa00140,hsa00380,hsa00980,hsa04913,hsa05204,hsa05206" Steroid hormone biosynthesis|Tryptophan metabolism|Metabolism of xenobiotics by cytochrome P450|Ovarian steroidogenesis|Chemical carcinogenesis|MicroRNAs in cancer CYP20A1 169.4100541 183.1128433 155.7072649 0.850335029 -0.233896726 0.553047346 1 3.896489594 3.257877641 57404 cytochrome P450 family 20 subfamily A member 1 "GO:0004497,GO:0005506,GO:0016020,GO:0016021,GO:0016705,GO:0020037,GO:0055114" "monooxygenase activity|iron ion binding|membrane|integral component of membrane|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|heme binding|oxidation-reduction process" CYP24A1 7.124381325 10.40413883 3.844623824 0.369528309 -1.436243205 0.311438224 1 0.136157373 0.049472067 1591 cytochrome P450 family 24 subfamily A member 1 "GO:0001649,GO:0005506,GO:0005654,GO:0005739,GO:0005741,GO:0006766,GO:0008403,GO:0010430,GO:0016491,GO:0020037,GO:0030342,GO:0033280,GO:0042359,GO:0042369,GO:0055114,GO:0062180,GO:0062181,GO:0070561,GO:0070643" "osteoblast differentiation|iron ion binding|nucleoplasm|mitochondrion|mitochondrial outer membrane|vitamin metabolic process|25-hydroxycholecalciferol-24-hydroxylase activity|fatty acid omega-oxidation|oxidoreductase activity|heme binding|1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|response to vitamin D|vitamin D metabolic process|vitamin D catabolic process|oxidation-reduction process|25-hydroxycholecalciferol-23-hydroxylase activity|1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity|vitamin D receptor signaling pathway|vitamin D 25-hydroxylase activity" "hsa00100,hsa04928,hsa05206" "Steroid biosynthesis|Parathyroid hormone synthesis, secretion and action|MicroRNAs in cancer" CYP26B1 621.3937001 580.5509465 662.2364537 1.140703426 0.189923751 0.46943076 1 6.495374635 7.285311563 56603 cytochrome P450 family 26 subfamily B member 1 "GO:0001709,GO:0001768,GO:0001822,GO:0001972,GO:0004497,GO:0005506,GO:0005515,GO:0005737,GO:0005789,GO:0006766,GO:0006805,GO:0006954,GO:0007140,GO:0007283,GO:0008401,GO:0009954,GO:0010628,GO:0016125,GO:0016491,GO:0016709,GO:0020037,GO:0030326,GO:0033189,GO:0034653,GO:0042573,GO:0043587,GO:0045580,GO:0048384,GO:0048387,GO:0055114,GO:0060349,GO:0061436,GO:0070268,GO:0071300,GO:2001037" "cell fate determination|establishment of T cell polarity|kidney development|retinoic acid binding|monooxygenase activity|iron ion binding|protein binding|cytoplasm|endoplasmic reticulum membrane|vitamin metabolic process|xenobiotic metabolic process|inflammatory response|male meiotic nuclear division|spermatogenesis|retinoic acid 4-hydroxylase activity|proximal/distal pattern formation|positive regulation of gene expression|sterol metabolic process|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|heme binding|embryonic limb morphogenesis|response to vitamin A|retinoic acid catabolic process|retinoic acid metabolic process|tongue morphogenesis|regulation of T cell differentiation|retinoic acid receptor signaling pathway|negative regulation of retinoic acid receptor signaling pathway|oxidation-reduction process|bone morphogenesis|establishment of skin barrier|cornification|cellular response to retinoic acid|positive regulation of tongue muscle cell differentiation" hsa00830 Retinol metabolism CYP27A1 3.081612685 5.202069413 0.961155956 0.184764154 -2.436243205 0.338470402 1 0.120235982 0.021843557 1593 cytochrome P450 family 27 subfamily A member 1 "GO:0005506,GO:0005739,GO:0005743,GO:0005759,GO:0006699,GO:0006707,GO:0008203,GO:0008395,GO:0016125,GO:0020037,GO:0030343,GO:0031073,GO:0036378,GO:0047749,GO:0055114" iron ion binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|bile acid biosynthetic process|cholesterol catabolic process|cholesterol metabolic process|steroid hydroxylase activity|sterol metabolic process|heme binding|vitamin D3 25-hydroxylase activity|cholesterol 26-hydroxylase activity|calcitriol biosynthetic process from calciol|cholestanetriol 26-monooxygenase activity|oxidation-reduction process "hsa00120,hsa03320,hsa04979" Primary bile acid biosynthesis|PPAR signaling pathway|Cholesterol metabolism CYP27B1 252.0493447 233.0527097 271.0459796 1.163024364 0.21788132 0.519469802 1 5.24350539 5.996277321 1594 cytochrome P450 family 27 subfamily B member 1 "GO:0004498,GO:0005506,GO:0005737,GO:0005739,GO:0005741,GO:0006766,GO:0006816,GO:0008285,GO:0010956,GO:0010980,GO:0020037,GO:0030282,GO:0030308,GO:0030500,GO:0032496,GO:0033280,GO:0034341,GO:0036378,GO:0042359,GO:0042369,GO:0043627,GO:0045618,GO:0046697,GO:0055074,GO:0055114,GO:0062185,GO:0070314,GO:0070564" calcidiol 1-monooxygenase activity|iron ion binding|cytoplasm|mitochondrion|mitochondrial outer membrane|vitamin metabolic process|calcium ion transport|negative regulation of cell population proliferation|negative regulation of calcidiol 1-monooxygenase activity|positive regulation of vitamin D 24-hydroxylase activity|heme binding|bone mineralization|negative regulation of cell growth|regulation of bone mineralization|response to lipopolysaccharide|response to vitamin D|response to interferon-gamma|calcitriol biosynthetic process from calciol|vitamin D metabolic process|vitamin D catabolic process|response to estrogen|positive regulation of keratinocyte differentiation|decidualization|calcium ion homeostasis|oxidation-reduction process|secalciferol 1-monooxygenase activity|G1 to G0 transition|positive regulation of vitamin D receptor signaling pathway "hsa00100,hsa04928,hsa05152" "Steroid biosynthesis|Parathyroid hormone synthesis, secretion and action|Tuberculosis" CYP27C1 44.35659857 41.61655531 47.09664184 1.131680445 0.178466639 0.807095994 1 0.454377878 0.505605942 339761 cytochrome P450 family 27 subfamily C member 1 "GO:0001972,GO:0004497,GO:0005502,GO:0005503,GO:0005506,GO:0005739,GO:0016020,GO:0020037,GO:0042572,GO:0042573,GO:0042574,GO:0043231,GO:0055114,GO:0061896,GO:0061897,GO:0061898,GO:0061899,GO:1904768" "retinoic acid binding|monooxygenase activity|11-cis retinal binding|all-trans retinal binding|iron ion binding|mitochondrion|membrane|heme binding|retinol metabolic process|retinoic acid metabolic process|retinal metabolic process|intracellular membrane-bounded organelle|oxidation-reduction process|all-trans retinol 3,4-desaturase activity|all-trans retinal 3,4-desaturase activity|all-trans retinoic acid 3,4-desaturase activity|11-cis-retinal 3,4-desaturase activity|all-trans-retinol binding" hsa00830 Retinol metabolism CYP2C8 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.082299867 0 1558 cytochrome P450 family 2 subfamily C member 8 "GO:0002933,GO:0004497,GO:0005506,GO:0005515,GO:0005737,GO:0005789,GO:0006082,GO:0006805,GO:0008202,GO:0008210,GO:0008392,GO:0008395,GO:0008401,GO:0016712,GO:0017144,GO:0019373,GO:0020037,GO:0034875,GO:0042572,GO:0042573,GO:0042738,GO:0042759,GO:0043231,GO:0046456,GO:0055114,GO:0070330,GO:0070989,GO:0097267,GO:0101020" "lipid hydroxylation|monooxygenase activity|iron ion binding|protein binding|cytoplasm|endoplasmic reticulum membrane|organic acid metabolic process|xenobiotic metabolic process|steroid metabolic process|estrogen metabolic process|arachidonic acid epoxygenase activity|steroid hydroxylase activity|retinoic acid 4-hydroxylase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|drug metabolic process|epoxygenase P450 pathway|heme binding|caffeine oxidase activity|retinol metabolic process|retinoic acid metabolic process|exogenous drug catabolic process|long-chain fatty acid biosynthetic process|intracellular membrane-bounded organelle|icosanoid biosynthetic process|oxidation-reduction process|aromatase activity|oxidative demethylation|omega-hydroxylase P450 pathway|estrogen 16-alpha-hydroxylase activity" "hsa00590,hsa00591,hsa00830,hsa00982,hsa04726,hsa05204" Arachidonic acid metabolism|Linoleic acid metabolism|Retinol metabolism|Drug metabolism - cytochrome P450|Serotonergic synapse|Chemical carcinogenesis CYP2E1 35.98862813 36.41448589 35.56277037 0.97661053 -0.034144761 1 1 1.160916479 1.114791265 1571 cytochrome P450 family 2 subfamily E member 1 "GO:0000139,GO:0002933,GO:0004497,GO:0005506,GO:0005737,GO:0005743,GO:0005789,GO:0006082,GO:0006641,GO:0006805,GO:0008202,GO:0008392,GO:0008395,GO:0009617,GO:0010193,GO:0010243,GO:0016098,GO:0016491,GO:0016709,GO:0016712,GO:0017144,GO:0018601,GO:0018885,GO:0018910,GO:0018960,GO:0019373,GO:0019825,GO:0019899,GO:0020037,GO:0030544,GO:0031227,GO:0042197,GO:0042738,GO:0042759,GO:0043231,GO:0045471,GO:0046483,GO:0051879,GO:0055114,GO:0070330" "Golgi membrane|lipid hydroxylation|monooxygenase activity|iron ion binding|cytoplasm|mitochondrial inner membrane|endoplasmic reticulum membrane|organic acid metabolic process|triglyceride metabolic process|xenobiotic metabolic process|steroid metabolic process|arachidonic acid epoxygenase activity|steroid hydroxylase activity|response to bacterium|response to ozone|response to organonitrogen compound|monoterpenoid metabolic process|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|drug metabolic process|4-nitrophenol 2-monooxygenase activity|carbon tetrachloride metabolic process|benzene metabolic process|4-nitrophenol metabolic process|epoxygenase P450 pathway|oxygen binding|enzyme binding|heme binding|Hsp70 protein binding|intrinsic component of endoplasmic reticulum membrane|halogenated hydrocarbon metabolic process|exogenous drug catabolic process|long-chain fatty acid biosynthetic process|intracellular membrane-bounded organelle|response to ethanol|heterocycle metabolic process|Hsp90 protein binding|oxidation-reduction process|aromatase activity" "hsa00140,hsa00590,hsa00591,hsa00980,hsa00982,hsa00983,hsa04932,hsa05204" Steroid hormone biosynthesis|Arachidonic acid metabolism|Linoleic acid metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Non-alcoholic fatty liver disease|Chemical carcinogenesis CYP2J2 30.54375452 32.25283036 28.83467868 0.894020102 -0.161620825 0.865545159 1 0.91605869 0.805270447 1573 cytochrome P450 family 2 subfamily J member 2 "GO:0005506,GO:0005737,GO:0005789,GO:0006082,GO:0006690,GO:0006805,GO:0008016,GO:0008392,GO:0008395,GO:0008404,GO:0008405,GO:0016712,GO:0016853,GO:0019373,GO:0020037,GO:0042738,GO:0043231,GO:0043651,GO:0055114,GO:0070062,GO:0071614,GO:0106255" "iron ion binding|cytoplasm|endoplasmic reticulum membrane|organic acid metabolic process|icosanoid metabolic process|xenobiotic metabolic process|regulation of heart contraction|arachidonic acid epoxygenase activity|steroid hydroxylase activity|arachidonic acid 14,15-epoxygenase activity|arachidonic acid 11,12-epoxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|isomerase activity|epoxygenase P450 pathway|heme binding|exogenous drug catabolic process|intracellular membrane-bounded organelle|linoleic acid metabolic process|oxidation-reduction process|extracellular exosome|linoleic acid epoxygenase activity|hydroperoxy icosatetraenoate isomerase activity" "hsa00590,hsa00591,hsa04726,hsa04750,hsa04913" Arachidonic acid metabolism|Linoleic acid metabolism|Serotonergic synapse|Inflammatory mediator regulation of TRP channels|Ovarian steroidogenesis CYP2R1 100.0835223 91.55642167 108.610623 1.186269855 0.246432234 0.610495808 1 0.407692779 0.475540699 120227 cytochrome P450 family 2 subfamily R member 1 "GO:0005506,GO:0005737,GO:0005789,GO:0006082,GO:0006766,GO:0006805,GO:0008395,GO:0010164,GO:0010212,GO:0016712,GO:0020037,GO:0030343,GO:0036378,GO:0042359,GO:0042738,GO:0042803,GO:0043231,GO:0055114,GO:1902271" "iron ion binding|cytoplasm|endoplasmic reticulum membrane|organic acid metabolic process|vitamin metabolic process|xenobiotic metabolic process|steroid hydroxylase activity|response to cesium ion|response to ionizing radiation|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|heme binding|vitamin D3 25-hydroxylase activity|calcitriol biosynthetic process from calciol|vitamin D metabolic process|exogenous drug catabolic process|protein homodimerization activity|intracellular membrane-bounded organelle|oxidation-reduction process|D3 vitamins binding" hsa00100 Steroid biosynthesis CYP2S1 44.4358565 43.69738307 45.17432993 1.033799435 0.047956319 0.979515695 1 0.892821218 0.907552948 29785 cytochrome P450 family 2 subfamily S member 1 "GO:0004497,GO:0004796,GO:0005506,GO:0005515,GO:0005737,GO:0005783,GO:0005789,GO:0006082,GO:0006690,GO:0006693,GO:0006805,GO:0008392,GO:0008395,GO:0008401,GO:0016712,GO:0016836,GO:0019373,GO:0020037,GO:0042573,GO:0042738,GO:0043231,GO:0055114,GO:0106256" "monooxygenase activity|thromboxane-A synthase activity|iron ion binding|protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|organic acid metabolic process|icosanoid metabolic process|prostaglandin metabolic process|xenobiotic metabolic process|arachidonic acid epoxygenase activity|steroid hydroxylase activity|retinoic acid 4-hydroxylase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|hydro-lyase activity|epoxygenase P450 pathway|heme binding|retinoic acid metabolic process|exogenous drug catabolic process|intracellular membrane-bounded organelle|oxidation-reduction process|hydroperoxy icosatetraenoate dehydratase activity" "hsa00830,hsa00980" Retinol metabolism|Metabolism of xenobiotics by cytochrome P450 CYP2U1 239.9210387 217.4465015 262.395576 1.206713257 0.271082899 0.42884075 1 2.433875867 2.88784372 113612 cytochrome P450 family 2 subfamily U member 1 "GO:0004497,GO:0005506,GO:0005737,GO:0005743,GO:0005789,GO:0006082,GO:0006805,GO:0008395,GO:0016021,GO:0016712,GO:0020037,GO:0042738,GO:0043231,GO:0052869,GO:0055114,GO:0097267,GO:0102033" "monooxygenase activity|iron ion binding|cytoplasm|mitochondrial inner membrane|endoplasmic reticulum membrane|organic acid metabolic process|xenobiotic metabolic process|steroid hydroxylase activity|integral component of membrane|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|heme binding|exogenous drug catabolic process|intracellular membrane-bounded organelle|arachidonic acid omega-hydroxylase activity|oxidation-reduction process|omega-hydroxylase P450 pathway|long-chain fatty acid omega-hydroxylase activity" "hsa00071,hsa00590" Fatty acid degradation|Arachidonic acid metabolism CYP39A1 36.18677295 41.61655531 30.75699059 0.739056617 -0.436243205 0.53600437 1 0.393515072 0.285963273 51302 cytochrome P450 family 39 subfamily A member 1 "GO:0005506,GO:0005789,GO:0006699,GO:0006707,GO:0007586,GO:0008387,GO:0008395,GO:0008396,GO:0016021,GO:0016125,GO:0020037,GO:0042632,GO:0043231,GO:0055114" iron ion binding|endoplasmic reticulum membrane|bile acid biosynthetic process|cholesterol catabolic process|digestion|steroid 7-alpha-hydroxylase activity|steroid hydroxylase activity|oxysterol 7-alpha-hydroxylase activity|integral component of membrane|sterol metabolic process|heme binding|cholesterol homeostasis|intracellular membrane-bounded organelle|oxidation-reduction process hsa00120 Primary bile acid biosynthesis CYP3A5 10.8104893 6.242483296 15.3784953 2.463522058 1.300722389 0.255870018 1 0.054021382 0.130855904 1577 cytochrome P450 family 3 subfamily A member 5 "GO:0002933,GO:0004497,GO:0005506,GO:0005515,GO:0005789,GO:0006805,GO:0008202,GO:0008210,GO:0008395,GO:0008401,GO:0009822,GO:0016491,GO:0019825,GO:0020037,GO:0042572,GO:0042573,GO:0042737,GO:0043231,GO:0050649,GO:0070330,GO:0070989,GO:0101020" lipid hydroxylation|monooxygenase activity|iron ion binding|protein binding|endoplasmic reticulum membrane|xenobiotic metabolic process|steroid metabolic process|estrogen metabolic process|steroid hydroxylase activity|retinoic acid 4-hydroxylase activity|alkaloid catabolic process|oxidoreductase activity|oxygen binding|heme binding|retinol metabolic process|retinoic acid metabolic process|drug catabolic process|intracellular membrane-bounded organelle|testosterone 6-beta-hydroxylase activity|aromatase activity|oxidative demethylation|estrogen 16-alpha-hydroxylase activity "hsa00140,hsa00830,hsa00980,hsa00982,hsa05204" Steroid hormone biosynthesis|Retinol metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Chemical carcinogenesis CYP4F11 64.92710245 76.99062732 52.86357758 0.686623547 -0.542408762 0.323826707 1 1.331016611 0.898614344 57834 cytochrome P450 family 4 subfamily F member 11 "GO:0005504,GO:0005506,GO:0005515,GO:0005789,GO:0006631,GO:0006954,GO:0007596,GO:0008391,GO:0016021,GO:0016709,GO:0019369,GO:0020037,GO:0031408,GO:0036101,GO:0042361,GO:0042376,GO:0042377,GO:0043231,GO:0050051,GO:0055114,GO:0070330,GO:0102033" "fatty acid binding|iron ion binding|protein binding|endoplasmic reticulum membrane|fatty acid metabolic process|inflammatory response|blood coagulation|arachidonic acid monooxygenase activity|integral component of membrane|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|arachidonic acid metabolic process|heme binding|oxylipin biosynthetic process|leukotriene B4 catabolic process|menaquinone catabolic process|phylloquinone catabolic process|vitamin K catabolic process|intracellular membrane-bounded organelle|leukotriene-B4 20-monooxygenase activity|oxidation-reduction process|aromatase activity|long-chain fatty acid omega-hydroxylase activity" CYP4V2 109.764279 118.6071826 100.9213754 0.850887553 -0.232959606 0.618328354 1 1.359211369 1.137182971 285440 cytochrome P450 family 4 subfamily V member 2 "GO:0001523,GO:0004497,GO:0005506,GO:0005789,GO:0007601,GO:0010430,GO:0016021,GO:0016125,GO:0020037,GO:0050896,GO:0102033" retinoid metabolic process|monooxygenase activity|iron ion binding|endoplasmic reticulum membrane|visual perception|fatty acid omega-oxidation|integral component of membrane|sterol metabolic process|heme binding|response to stimulus|long-chain fatty acid omega-hydroxylase activity CYP4X1 5.003924597 5.202069413 4.80577978 0.923820772 -0.11431511 1 1 0.093919108 0.085312538 260293 cytochrome P450 family 4 subfamily X member 1 "GO:0005506,GO:0005789,GO:0016021,GO:0020037,GO:0055114,GO:0062189" "iron ion binding|endoplasmic reticulum membrane|integral component of membrane|heme binding|oxidation-reduction process|anandamide 14,15 epoxidase activity" hsa04726 Serotonergic synapse CYP51A1 1412.093659 1303.638595 1520.548722 1.166388237 0.222048075 0.354117912 1 21.12748127 24.23048098 1595 cytochrome P450 family 51 subfamily A member 1 "GO:0004497,GO:0005506,GO:0005783,GO:0005789,GO:0006694,GO:0006695,GO:0008398,GO:0016020,GO:0016021,GO:0016125,GO:0016491,GO:0020037,GO:0042177,GO:0045540,GO:0050709,GO:0055114,GO:0070988,GO:1900222" monooxygenase activity|iron ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|steroid biosynthetic process|cholesterol biosynthetic process|sterol 14-demethylase activity|membrane|integral component of membrane|sterol metabolic process|oxidoreductase activity|heme binding|negative regulation of protein catabolic process|regulation of cholesterol biosynthetic process|negative regulation of protein secretion|oxidation-reduction process|demethylation|negative regulation of amyloid-beta clearance hsa00100 Steroid biosynthesis CYREN 1099.312851 1116.364096 1082.261606 0.96945218 -0.044758359 0.857839544 1 5.782616715 5.512162058 78996 cell cycle regulator of NHEJ "GO:0005515,GO:0005634,GO:0005737,GO:0006303,GO:2001033" protein binding|nucleus|cytoplasm|double-strand break repair via nonhomologous end joining|negative regulation of double-strand break repair via nonhomologous end joining CYRIA 5.444873611 4.161655531 6.728091692 1.616686351 0.693039812 0.747994079 1 0.04287643 0.0681578 81553 CYFIP related Rac1 interactor A "GO:0003674,GO:0005575,GO:0008150,GO:0016020,GO:0030833" molecular_function|cellular_component|biological_process|membrane|regulation of actin filament polymerization CYRIB 2372.832704 2238.970675 2506.694733 1.119574616 0.162950682 0.491077003 1 26.55917979 29.23740883 51571 CYFIP related Rac1 interactor B "GO:0001916,GO:0002576,GO:0005515,GO:0005576,GO:0005739,GO:0005929,GO:0016020,GO:0023030,GO:0030334,GO:0030837,GO:0031093,GO:0031267,GO:0032729,GO:0050870,GO:0050920,GO:0051058,GO:0070062,GO:0071219,GO:0090140,GO:2000114,GO:2000568" "positive regulation of T cell mediated cytotoxicity|platelet degranulation|protein binding|extracellular region|mitochondrion|cilium|membrane|MHC class Ib protein binding, via antigen binding groove|regulation of cell migration|negative regulation of actin filament polymerization|platelet alpha granule lumen|small GTPase binding|positive regulation of interferon-gamma production|positive regulation of T cell activation|regulation of chemotaxis|negative regulation of small GTPase mediated signal transduction|extracellular exosome|cellular response to molecule of bacterial origin|regulation of mitochondrial fission|regulation of establishment of cell polarity|positive regulation of memory T cell activation" CYS1 246.4704929 263.2247123 229.7162735 0.872700255 -0.196441877 0.565415592 1 5.166538841 4.433390436 192668 cystin 1 "GO:0005515,GO:0005829,GO:0005856,GO:0005929,GO:0060170" protein binding|cytosol|cytoskeleton|cilium|ciliary membrane CYSLTR1 2.40288989 0 4.80577978 Inf Inf 0.18976424 1 0 0.088703434 10800 cysteinyl leukotriene receptor 1 "GO:0001631,GO:0002437,GO:0004974,GO:0005515,GO:0005886,GO:0005887,GO:0006816,GO:0006935,GO:0006952,GO:0007166,GO:0007186,GO:0007204,GO:0007218,GO:0007585,GO:0008528,GO:0016020,GO:0061737" cysteinyl leukotriene receptor activity|inflammatory response to antigenic stimulus|leukotriene receptor activity|protein binding|plasma membrane|integral component of plasma membrane|calcium ion transport|chemotaxis|defense response|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|respiratory gaseous exchange by respiratory system|G protein-coupled peptide receptor activity|membrane|leukotriene signaling pathway "hsa04020,hsa04080" Calcium signaling pathway|Neuroactive ligand-receptor interaction CYSRT1 12.52962597 13.52538047 11.53387147 0.852757635 -0.229792327 0.900893758 1 0.947276506 0.79427988 375791 cysteine rich tail 1 "GO:0005515,GO:0042802,GO:0070062" protein binding|identical protein binding|extracellular exosome CYSTM1 652.6010862 655.4607461 649.7414263 0.991274352 -0.012643692 0.967623584 1 44.27941181 43.15855458 84418 cysteine rich transmembrane module containing 1 "GO:0003674,GO:0005515,GO:0005886,GO:0008150,GO:0016021,GO:0043312,GO:0070062,GO:0070821" molecular_function|protein binding|plasma membrane|biological_process|integral component of membrane|neutrophil degranulation|extracellular exosome|tertiary granule membrane CYTH1 1070.666871 1045.615952 1095.71779 1.047916099 0.067523213 0.785456506 1 12.90531952 13.29739142 9267 cytohesin 1 "GO:0000139,GO:0005085,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0005923,GO:0008289,GO:0016192,GO:0030155,GO:0031234,GO:0032012,GO:0050790,GO:0090162" Golgi membrane|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|cytosol|plasma membrane|adherens junction|bicellular tight junction|lipid binding|vesicle-mediated transport|regulation of cell adhesion|extrinsic component of cytoplasmic side of plasma membrane|regulation of ARF protein signal transduction|regulation of catalytic activity|establishment of epithelial cell polarity "hsa04072,hsa04144,hsa05130,hsa05131,hsa05132" Phospholipase D signaling pathway|Endocytosis|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection CYTH2 901.3115371 826.0886228 976.5344513 1.182118267 0.24137438 0.331674291 1 22.81927097 26.52368567 9266 cytohesin 2 "GO:0000139,GO:0005085,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0005923,GO:0006897,GO:0008289,GO:0016020,GO:0030036,GO:0030426,GO:0032012,GO:0050790,GO:0070679" "Golgi membrane|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|cytosol|plasma membrane|adherens junction|bicellular tight junction|endocytosis|lipid binding|membrane|actin cytoskeleton organization|growth cone|regulation of ARF protein signal transduction|regulation of catalytic activity|inositol 1,4,5 trisphosphate binding" "hsa04072,hsa04144,hsa05130,hsa05131,hsa05132" Phospholipase D signaling pathway|Endocytosis|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection CYTH3 1744.649933 1909.159475 1580.140392 0.82766286 -0.272884874 0.250185407 1 17.62164169 14.34072185 9265 cytohesin 3 "GO:0000139,GO:0001726,GO:0005085,GO:0005515,GO:0005547,GO:0005654,GO:0005829,GO:0005886,GO:0005912,GO:0005923,GO:0031234,GO:0032012,GO:0045785,GO:0048193,GO:0050790,GO:0090162" "Golgi membrane|ruffle|guanyl-nucleotide exchange factor activity|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleoplasm|cytosol|plasma membrane|adherens junction|bicellular tight junction|extrinsic component of cytoplasmic side of plasma membrane|regulation of ARF protein signal transduction|positive regulation of cell adhesion|Golgi vesicle transport|regulation of catalytic activity|establishment of epithelial cell polarity" "hsa04072,hsa04144,hsa05130,hsa05131,hsa05132" Phospholipase D signaling pathway|Endocytosis|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection CYTH4 113.6931912 108.2030438 119.1833385 1.101478612 0.139441482 0.771461392 1 1.865180096 2.020077446 27128 cytohesin 4 "GO:0000139,GO:0005085,GO:0005515,GO:0005829,GO:0005886,GO:0008289,GO:0032012,GO:0034451,GO:0045171,GO:0050790" Golgi membrane|guanyl-nucleotide exchange factor activity|protein binding|cytosol|plasma membrane|lipid binding|regulation of ARF protein signal transduction|centriolar satellite|intercellular bridge|regulation of catalytic activity "hsa04072,hsa04144,hsa05130,hsa05131,hsa05132" Phospholipase D signaling pathway|Endocytosis|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection CYYR1 53.56683808 43.69738307 63.4362931 1.451718356 0.537761587 0.36477418 1 0.387576703 0.553236991 116159 cysteine and tyrosine rich 1 "GO:0003674,GO:0008150,GO:0016021" molecular_function|biological_process|integral component of membrane CZIB 445.6713512 458.8225222 432.5201802 0.942674257 -0.085168764 0.768345175 1 22.22006782 20.59577819 54987 CXXC motif containing zinc binding protein "GO:0005515,GO:0008150,GO:0008270" protein binding|biological_process|zinc ion binding D2HGDH 658.6800232 676.2690237 641.0910226 0.947982238 -0.077068067 0.770488182 1 8.410914674 7.839973704 728294 D-2-hydroxyglutarate dehydrogenase "GO:0005739,GO:0005759,GO:0006103,GO:0010042,GO:0010043,GO:0032025,GO:0032026,GO:0044267,GO:0051592,GO:0051990,GO:0055114,GO:0071949" mitochondrion|mitochondrial matrix|2-oxoglutarate metabolic process|response to manganese ion|response to zinc ion|response to cobalt ion|response to magnesium ion|cellular protein metabolic process|response to calcium ion|(R)-2-hydroxyglutarate dehydrogenase activity|oxidation-reduction process|FAD binding DAAM1 448.9806768 495.2370081 402.7243456 0.813195175 -0.29832644 0.288330365 1 4.348451615 3.476967361 23002 dishevelled associated activator of morphogenesis 1 "GO:0001725,GO:0003779,GO:0005515,GO:0005829,GO:0005886,GO:0016020,GO:0030036,GO:0031514,GO:0036064,GO:0042802,GO:0060071" "stress fiber|actin binding|protein binding|cytosol|plasma membrane|membrane|actin cytoskeleton organization|motile cilium|ciliary basal body|identical protein binding|Wnt signaling pathway, planar cell polarity pathway" hsa04310 Wnt signaling pathway DAB2 1189.83892 1272.426178 1107.251661 0.870189312 -0.200598797 0.40840387 1 15.62877941 13.37241928 1601 DAB adaptor protein 2 "GO:0000122,GO:0001650,GO:0001934,GO:0005515,GO:0005737,GO:0005765,GO:0005829,GO:0005886,GO:0005905,GO:0005925,GO:0006898,GO:0006915,GO:0007229,GO:0007275,GO:0008022,GO:0010718,GO:0010862,GO:0015031,GO:0016055,GO:0030136,GO:0030335,GO:0030511,GO:0030665,GO:0032091,GO:0032436,GO:0035026,GO:0035615,GO:0038024,GO:0043066,GO:0043231,GO:0045807,GO:0045944,GO:0046332,GO:0060391,GO:0060766,GO:0061024,GO:0090090,GO:1903077,GO:2000096,GO:2000370,GO:2000643" "negative regulation of transcription by RNA polymerase II|fibrillar center|positive regulation of protein phosphorylation|protein binding|cytoplasm|lysosomal membrane|cytosol|plasma membrane|clathrin-coated pit|focal adhesion|receptor-mediated endocytosis|apoptotic process|integrin-mediated signaling pathway|multicellular organism development|protein C-terminus binding|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|protein transport|Wnt signaling pathway|clathrin-coated vesicle|positive regulation of cell migration|positive regulation of transforming growth factor beta receptor signaling pathway|clathrin-coated vesicle membrane|negative regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|leading edge cell differentiation|clathrin adaptor activity|cargo receptor activity|negative regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of endocytosis|positive regulation of transcription by RNA polymerase II|SMAD binding|positive regulation of SMAD protein signal transduction|negative regulation of androgen receptor signaling pathway|membrane organization|negative regulation of canonical Wnt signaling pathway|negative regulation of protein localization to plasma membrane|positive regulation of Wnt signaling pathway, planar cell polarity pathway|positive regulation of clathrin-dependent endocytosis|positive regulation of early endosome to late endosome transport" hsa04144 Endocytosis DAB2IP 1002.578898 961.3424276 1043.815368 1.085789349 0.118744236 0.631324437 1 4.28685482 4.576732519 153090 DAB2 interacting protein "GO:0000122,GO:0000165,GO:0000185,GO:0001525,GO:0001933,GO:0005096,GO:0005123,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0006954,GO:0007049,GO:0007252,GO:0007257,GO:0008285,GO:0008625,GO:0010596,GO:0010633,GO:0010719,GO:0010976,GO:0014067,GO:0016525,GO:0017124,GO:0019900,GO:0019901,GO:0021814,GO:0021819,GO:0030139,GO:0030424,GO:0030425,GO:0030948,GO:0031334,GO:0031434,GO:0031435,GO:0032088,GO:0032266,GO:0032809,GO:0034144,GO:0034260,GO:0034620,GO:0035148,GO:0035591,GO:0035662,GO:0035924,GO:0036312,GO:0036324,GO:0038026,GO:0040008,GO:0042059,GO:0042802,GO:0042803,GO:0043025,GO:0043065,GO:0043087,GO:0043122,GO:0043124,GO:0043184,GO:0043254,GO:0043407,GO:0043410,GO:0043507,GO:0043547,GO:0043548,GO:0043553,GO:0044257,GO:0044300,GO:0044301,GO:0044877,GO:0045087,GO:0045296,GO:0045732,GO:0045892,GO:0045944,GO:0046330,GO:0046580,GO:0048147,GO:0048812,GO:0050680,GO:0051721,GO:0070059,GO:0070273,GO:0070317,GO:0070373,GO:0071158,GO:0071222,GO:0071347,GO:0071356,GO:0071364,GO:0071889,GO:0071901,GO:0071902,GO:0072577,GO:0090090,GO:0090129,GO:1900006,GO:1900744,GO:1900747,GO:1901800,GO:1903363,GO:1903896,GO:1990032,GO:1990597,GO:2001224,GO:2001235" "negative regulation of transcription by RNA polymerase II|MAPK cascade|activation of MAPKKK activity|angiogenesis|negative regulation of protein phosphorylation|GTPase activator activity|death receptor binding|protein binding|cytoplasm|cytosol|plasma membrane|inflammatory response|cell cycle|I-kappaB phosphorylation|activation of JUN kinase activity|negative regulation of cell population proliferation|extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of endothelial cell migration|negative regulation of epithelial cell migration|negative regulation of epithelial to mesenchymal transition|positive regulation of neuron projection development|negative regulation of phosphatidylinositol 3-kinase signaling|negative regulation of angiogenesis|SH3 domain binding|kinase binding|protein kinase binding|cell motility involved in cerebral cortex radial glia guided migration|layer formation in cerebral cortex|endocytic vesicle|axon|dendrite|negative regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of protein-containing complex assembly|mitogen-activated protein kinase kinase binding|mitogen-activated protein kinase kinase kinase binding|negative regulation of NF-kappaB transcription factor activity|phosphatidylinositol-3-phosphate binding|neuronal cell body membrane|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of GTPase activity|cellular response to unfolded protein|tube formation|signaling adaptor activity|Toll-like receptor 4 binding|cellular response to vascular endothelial growth factor stimulus|phosphatidylinositol 3-kinase regulatory subunit binding|vascular endothelial growth factor receptor-2 signaling pathway|reelin-mediated signaling pathway|regulation of growth|negative regulation of epidermal growth factor receptor signaling pathway|identical protein binding|protein homodimerization activity|neuronal cell body|positive regulation of apoptotic process|regulation of GTPase activity|regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|vascular endothelial growth factor receptor 2 binding|regulation of protein-containing complex assembly|negative regulation of MAP kinase activity|positive regulation of MAPK cascade|positive regulation of JUN kinase activity|positive regulation of GTPase activity|phosphatidylinositol 3-kinase binding|negative regulation of phosphatidylinositol 3-kinase activity|cellular protein catabolic process|cerebellar mossy fiber|climbing fiber|protein-containing complex binding|innate immune response|cadherin binding|positive regulation of protein catabolic process|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|negative regulation of Ras protein signal transduction|negative regulation of fibroblast proliferation|neuron projection morphogenesis|negative regulation of epithelial cell proliferation|protein phosphatase 2A binding|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|phosphatidylinositol-4-phosphate binding|negative regulation of G0 to G1 transition|negative regulation of ERK1 and ERK2 cascade|positive regulation of cell cycle arrest|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|14-3-3 protein binding|negative regulation of protein serine/threonine kinase activity|positive regulation of protein serine/threonine kinase activity|endothelial cell apoptotic process|negative regulation of canonical Wnt signaling pathway|positive regulation of synapse maturation|positive regulation of dendrite development|regulation of p38MAPK cascade|negative regulation of vascular endothelial growth factor signaling pathway|positive regulation of proteasomal protein catabolic process|negative regulation of cellular protein catabolic process|positive regulation of IRE1-mediated unfolded protein response|parallel fiber|AIP1-IRE1 complex|positive regulation of neuron migration|positive regulation of apoptotic signaling pathway" "hsa04210,hsa04668" Apoptosis|TNF signaling pathway DACH1 73.58253647 64.50566072 82.65941222 1.281428812 0.357753334 0.503264033 1 0.304273339 0.383380097 1602 dachshund family transcription factor 1 "GO:0000122,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001967,GO:0005515,GO:0005634,GO:0005667,GO:0005737,GO:0006357,GO:0007585,GO:0008283,GO:0010944,GO:0030336,GO:0033262,GO:0045892,GO:0046545,GO:0048147,GO:0060244,GO:2000279" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|suckling behavior|protein binding|nucleus|transcription regulator complex|cytoplasm|regulation of transcription by RNA polymerase II|respiratory gaseous exchange by respiratory system|cell population proliferation|negative regulation of transcription by competitive promoter binding|negative regulation of cell migration|regulation of nuclear cell cycle DNA replication|negative regulation of transcription, DNA-templated|development of primary female sexual characteristics|negative regulation of fibroblast proliferation|negative regulation of cell proliferation involved in contact inhibition|negative regulation of DNA biosynthetic process" DACT1 15.53198073 16.64662212 14.41733934 0.866081974 -0.207424514 0.893114177 1 0.225539382 0.192066917 51339 dishevelled binding antagonist of beta catenin 1 "GO:0000122,GO:0001085,GO:0005080,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008013,GO:0016055,GO:0021915,GO:0030177,GO:0030178,GO:0030877,GO:0031647,GO:0032091,GO:0032092,GO:0042826,GO:0045202,GO:0045732,GO:0046329,GO:0048619,GO:0051018,GO:0060828,GO:0070097,GO:0090090,GO:0090263,GO:1900107,GO:1903364,GO:1904864,GO:2000095,GO:2000134" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription factor binding|protein kinase C binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|beta-catenin binding|Wnt signaling pathway|neural tube development|positive regulation of Wnt signaling pathway|negative regulation of Wnt signaling pathway|beta-catenin destruction complex|regulation of protein stability|negative regulation of protein binding|positive regulation of protein binding|histone deacetylase binding|synapse|positive regulation of protein catabolic process|negative regulation of JNK cascade|embryonic hindgut morphogenesis|protein kinase A binding|regulation of canonical Wnt signaling pathway|delta-catenin binding|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of nodal signaling pathway|positive regulation of cellular protein catabolic process|negative regulation of beta-catenin-TCF complex assembly|regulation of Wnt signaling pathway, planar cell polarity pathway|negative regulation of G1/S transition of mitotic cell cycle" DACT3 97.53720786 49.93986637 145.1345494 2.906186178 1.539127129 0.001407011 0.23754159 0.617945486 1.765813268 147906 dishevelled binding antagonist of beta catenin 3 "GO:0005080,GO:0005737,GO:0010719,GO:0016055,GO:0030178,GO:0030308,GO:0042802,GO:0051018,GO:0070097,GO:0090090" protein kinase C binding|cytoplasm|negative regulation of epithelial to mesenchymal transition|Wnt signaling pathway|negative regulation of Wnt signaling pathway|negative regulation of cell growth|identical protein binding|protein kinase A binding|delta-catenin binding|negative regulation of canonical Wnt signaling pathway DAD1 2163.857355 1950.77603 2376.938679 1.21845801 0.285056534 0.228043271 1 152.2066248 182.354003 1603 defender against cell death 1 "GO:0001824,GO:0005789,GO:0006486,GO:0006487,GO:0006915,GO:0007584,GO:0008047,GO:0008250,GO:0016020,GO:0016021,GO:0018279,GO:0031647,GO:0042493,GO:0043066,GO:0050790" blastocyst development|endoplasmic reticulum membrane|protein glycosylation|protein N-linked glycosylation|apoptotic process|response to nutrient|enzyme activator activity|oligosaccharyltransferase complex|membrane|integral component of membrane|protein N-linked glycosylation via asparagine|regulation of protein stability|response to drug|negative regulation of apoptotic process|regulation of catalytic activity "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum DAG1 1713.977231 1898.755336 1529.199126 0.805369232 -0.312277738 0.188378153 1 15.7227436 12.45072224 1605 dystroglycan 1 "GO:0001618,GO:0001954,GO:0002009,GO:0002011,GO:0002162,GO:0003779,GO:0005509,GO:0005515,GO:0005576,GO:0005604,GO:0005615,GO:0005654,GO:0005737,GO:0005788,GO:0005796,GO:0005829,GO:0005856,GO:0005886,GO:0005912,GO:0005925,GO:0006509,GO:0007411,GO:0007568,GO:0008307,GO:0009897,GO:0009925,GO:0010470,GO:0010717,GO:0014894,GO:0015631,GO:0016010,GO:0016011,GO:0016021,GO:0016203,GO:0016340,GO:0016476,GO:0017166,GO:0019048,GO:0021675,GO:0021682,GO:0022011,GO:0030027,GO:0030175,GO:0030198,GO:0030336,GO:0031103,GO:0031643,GO:0033268,GO:0034399,GO:0034453,GO:0042169,GO:0042383,GO:0043034,GO:0043231,GO:0043236,GO:0043237,GO:0043403,GO:0043409,GO:0043434,GO:0044853,GO:0045211,GO:0045860,GO:0046718,GO:0048714,GO:0050807,GO:0051393,GO:0051898,GO:0060055,GO:0060441,GO:0060445,GO:0062023,GO:0070062,GO:0070938,GO:0071260,GO:0071397,GO:0071679,GO:0071711,GO:0098696,GO:0098942,GO:0098978,GO:0098982,GO:0099524,GO:1904261" virus receptor activity|positive regulation of cell-matrix adhesion|morphogenesis of an epithelium|morphogenesis of an epithelial sheet|dystroglycan binding|actin binding|calcium ion binding|protein binding|extracellular region|basement membrane|extracellular space|nucleoplasm|cytoplasm|endoplasmic reticulum lumen|Golgi lumen|cytosol|cytoskeleton|plasma membrane|adherens junction|focal adhesion|membrane protein ectodomain proteolysis|axon guidance|aging|structural constituent of muscle|external side of plasma membrane|basal plasma membrane|regulation of gastrulation|regulation of epithelial to mesenchymal transition|response to denervation involved in regulation of muscle adaptation|tubulin binding|dystrophin-associated glycoprotein complex|dystroglycan complex|integral component of membrane|muscle attachment|calcium-dependent cell-matrix adhesion|regulation of embryonic cell shape|vinculin binding|modulation by virus of host process|nerve development|nerve maturation|myelination in peripheral nervous system|lamellipodium|filopodium|extracellular matrix organization|negative regulation of cell migration|axon regeneration|positive regulation of myelination|node of Ranvier|nuclear periphery|microtubule anchoring|SH2 domain binding|sarcolemma|costamere|intracellular membrane-bounded organelle|laminin binding|laminin-1 binding|skeletal muscle tissue regeneration|negative regulation of MAPK cascade|response to peptide hormone|plasma membrane raft|postsynaptic membrane|positive regulation of protein kinase activity|viral entry into host cell|positive regulation of oligodendrocyte differentiation|regulation of synapse organization|alpha-actinin binding|negative regulation of protein kinase B signaling|angiogenesis involved in wound healing|epithelial tube branching involved in lung morphogenesis|branching involved in salivary gland morphogenesis|collagen-containing extracellular matrix|extracellular exosome|contractile ring|cellular response to mechanical stimulus|cellular response to cholesterol|commissural neuron axon guidance|basement membrane organization|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane|retrograde trans-synaptic signaling by trans-synaptic protein complex|glutamatergic synapse|GABA-ergic synapse|postsynaptic cytosol|positive regulation of basement membrane assembly involved in embryonic body morphogenesis "hsa04512,hsa05410,hsa05412,hsa05414,hsa05416" ECM-receptor interaction|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Viral myocarditis DAGLA 43.31115427 52.02069413 34.60161442 0.665150956 -0.588246298 0.358634114 1 0.431563631 0.282251485 747 diacylglycerol lipase alpha "GO:0005515,GO:0005886,GO:0007216,GO:0007405,GO:0016787,GO:0019369,GO:0022008,GO:0031901,GO:0032590,GO:0032591,GO:0042136,GO:0043196,GO:0045211,GO:0046340,GO:0046872,GO:0071926,GO:0098839,GO:0098921,GO:0099055,GO:0150077" protein binding|plasma membrane|G protein-coupled glutamate receptor signaling pathway|neuroblast proliferation|hydrolase activity|arachidonic acid metabolic process|neurogenesis|early endosome membrane|dendrite membrane|dendritic spine membrane|neurotransmitter biosynthetic process|varicosity|postsynaptic membrane|diacylglycerol catabolic process|metal ion binding|endocannabinoid signaling pathway|postsynaptic density membrane|retrograde trans-synaptic signaling by endocannabinoid|integral component of postsynaptic membrane|regulation of neuroinflammatory response "hsa04723,hsa04925" Retrograde endocannabinoid signaling|Aldosterone synthesis and secretion DAGLB 666.8844474 689.7944042 643.9744905 0.933574536 -0.099162885 0.704950875 1 12.96691073 11.90300721 221955 diacylglycerol lipase beta "GO:0001516,GO:0004806,GO:0005515,GO:0005654,GO:0005765,GO:0005886,GO:0007216,GO:0007405,GO:0010898,GO:0016021,GO:0016042,GO:0016298,GO:0019369,GO:0022008,GO:0042136,GO:0045211,GO:0046872,GO:0050727,GO:0071926,GO:0098921" prostaglandin biosynthetic process|triglyceride lipase activity|protein binding|nucleoplasm|lysosomal membrane|plasma membrane|G protein-coupled glutamate receptor signaling pathway|neuroblast proliferation|positive regulation of triglyceride catabolic process|integral component of membrane|lipid catabolic process|lipase activity|arachidonic acid metabolic process|neurogenesis|neurotransmitter biosynthetic process|postsynaptic membrane|metal ion binding|regulation of inflammatory response|endocannabinoid signaling pathway|retrograde trans-synaptic signaling by endocannabinoid "hsa04723,hsa04925" Retrograde endocannabinoid signaling|Aldosterone synthesis and secretion DALRD3 729.1067195 721.0068207 737.2066182 1.0224683 0.032056115 0.905351398 1 18.97377163 19.07544596 55152 DALR anticodon binding domain containing 3 "GO:0004814,GO:0005515,GO:0005524,GO:0006420" arginine-tRNA ligase activity|protein binding|ATP binding|arginyl-tRNA aminoacylation DAND5 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.093528877 0.113277422 199699 DAN domain BMP antagonist family member 5 "GO:0003140,GO:0003281,GO:0003283,GO:0005576,GO:0005615,GO:0016015,GO:0023019,GO:0030512,GO:0030514,GO:0035582,GO:0038101,GO:0061371,GO:1900108,GO:1900176" determination of left/right asymmetry in lateral mesoderm|ventricular septum development|atrial septum development|extracellular region|extracellular space|morphogen activity|signal transduction involved in regulation of gene expression|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|sequestering of BMP in extracellular matrix|sequestering of nodal from receptor via nodal binding|determination of heart left/right asymmetry|negative regulation of nodal signaling pathway|negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry DAP 4435.267984 4239.686572 4630.849396 1.092262203 0.127319224 0.594467975 1 98.33302048 105.608157 1611 death associated protein "GO:0006914,GO:0006915,GO:0006919,GO:0010507,GO:0032088,GO:0034198,GO:0045892,GO:0070513,GO:0097190" "autophagy|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of autophagy|negative regulation of NF-kappaB transcription factor activity|cellular response to amino acid starvation|negative regulation of transcription, DNA-templated|death domain binding|apoptotic signaling pathway" DAP3 2497.87487 2607.27719 2388.472551 0.916079257 -0.126455673 0.59338609 1 68.61222468 61.80245528 7818 death associated protein 3 "GO:0003723,GO:0003735,GO:0005515,GO:0005525,GO:0005654,GO:0005739,GO:0005743,GO:0005763,GO:0070125,GO:0070126,GO:0097190" RNA binding|structural constituent of ribosome|protein binding|GTP binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination|apoptotic signaling pathway DAPK2 8.927806347 7.282897178 10.57271552 1.451718356 0.537761587 0.724794316 1 0.028242613 0.040314235 23604 death associated protein kinase 2 "GO:0004674,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005794,GO:0006468,GO:0006915,GO:0010506,GO:0031410,GO:0034423,GO:0035556,GO:0042802,GO:0042981,GO:0043065,GO:0043231,GO:0043276,GO:0046777,GO:0090023,GO:0106310,GO:0106311,GO:2000424,GO:2001242" protein serine/threonine kinase activity|protein binding|calmodulin binding|ATP binding|nucleus|cytoplasm|Golgi apparatus|protein phosphorylation|apoptotic process|regulation of autophagy|cytoplasmic vesicle|autophagosome lumen|intracellular signal transduction|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|intracellular membrane-bounded organelle|anoikis|protein autophosphorylation|positive regulation of neutrophil chemotaxis|protein serine kinase activity|protein threonine kinase activity|positive regulation of eosinophil chemotaxis|regulation of intrinsic apoptotic signaling pathway "hsa04140,hsa05200,hsa05219" Autophagy - animal|Pathways in cancer|Bladder cancer DAPK3 1017.803908 944.6958054 1090.91201 1.154775965 0.207612985 0.398527319 1 22.05454018 25.04187954 1613 death associated protein kinase 3 "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005884,GO:0006325,GO:0006355,GO:0006468,GO:0006915,GO:0006940,GO:0007088,GO:0007346,GO:0008022,GO:0008140,GO:0008360,GO:0010506,GO:0016605,GO:0017148,GO:0030182,GO:0030335,GO:0031267,GO:0035556,GO:0042802,GO:0042803,GO:0042981,GO:0043065,GO:0043519,GO:0043522,GO:0045121,GO:0046777,GO:0051893,GO:0071346,GO:0090263,GO:0097190,GO:0106310,GO:0106311,GO:2000145,GO:2000249,GO:2001241" "protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|actin filament|chromatin organization|regulation of transcription, DNA-templated|protein phosphorylation|apoptotic process|regulation of smooth muscle contraction|regulation of mitotic nuclear division|regulation of mitotic cell cycle|protein C-terminus binding|cAMP response element binding protein binding|regulation of cell shape|regulation of autophagy|PML body|negative regulation of translation|neuron differentiation|positive regulation of cell migration|small GTPase binding|intracellular signal transduction|identical protein binding|protein homodimerization activity|regulation of apoptotic process|positive regulation of apoptotic process|regulation of myosin II filament organization|leucine zipper domain binding|membrane raft|protein autophosphorylation|regulation of focal adhesion assembly|cellular response to interferon-gamma|positive regulation of canonical Wnt signaling pathway|apoptotic signaling pathway|protein serine kinase activity|protein threonine kinase activity|regulation of cell motility|regulation of actin cytoskeleton reorganization|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa04140,hsa05200,hsa05219" Autophagy - animal|Pathways in cancer|Bladder cancer DAPP1 4.523346619 5.202069413 3.844623824 0.739056617 -0.436243205 0.933440272 1 0.081798728 0.059442277 27071 dual adaptor of phosphotyrosine and 3-phosphoinositides 1 "GO:0005515,GO:0005543,GO:0005547,GO:0005829,GO:0005886,GO:0006470,GO:0007165,GO:0043325" "protein binding|phospholipid binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytosol|plasma membrane|protein dephosphorylation|signal transduction|phosphatidylinositol-3,4-bisphosphate binding" hsa04662 B cell receptor signaling pathway DARS1 2542.005599 2314.920889 2769.090309 1.196192199 0.258449215 0.274385601 1 39.86546408 46.88878386 1615 aspartyl-tRNA synthetase 1 "GO:0003723,GO:0004046,GO:0004815,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006412,GO:0006418,GO:0006422,GO:0016020,GO:0017101,GO:0045202,GO:0065003,GO:0070062" RNA binding|aminoacylase activity|aspartate-tRNA ligase activity|protein binding|ATP binding|cytoplasm|cytosol|translation|tRNA aminoacylation for protein translation|aspartyl-tRNA aminoacylation|membrane|aminoacyl-tRNA synthetase multienzyme complex|synapse|protein-containing complex assembly|extracellular exosome hsa00970 Aminoacyl-tRNA biosynthesis DARS2 1640.950114 1747.895323 1534.004906 0.877629733 -0.188315691 0.428851118 1 26.50808778 22.87498968 55157 "aspartyl-tRNA synthetase 2, mitochondrial" "GO:0000049,GO:0004815,GO:0005515,GO:0005524,GO:0005654,GO:0005739,GO:0005759,GO:0006418,GO:0042803,GO:0043039,GO:0050560,GO:0070145" tRNA binding|aspartate-tRNA ligase activity|protein binding|ATP binding|nucleoplasm|mitochondrion|mitochondrial matrix|tRNA aminoacylation for protein translation|protein homodimerization activity|tRNA aminoacylation|aspartate-tRNA(Asn) ligase activity|mitochondrial asparaginyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis DAW1 154.2101963 137.3346325 171.0857602 1.245758313 0.317024202 0.434798179 1 3.768276055 4.615807445 164781 dynein assembly factor with WD repeats 1 "GO:0005515,GO:0005575,GO:0005576,GO:0005929,GO:0007368,GO:0007507,GO:0008150,GO:0036158,GO:0051649,GO:0090660" protein binding|cellular_component|extracellular region|cilium|determination of left/right symmetry|heart development|biological_process|outer dynein arm assembly|establishment of localization in cell|cerebrospinal fluid circulation DAXX 1302.428145 1238.09252 1366.763769 1.103927006 0.142644782 0.55471073 1 25.88120732 28.09286733 1616 death domain associated protein "GO:0000775,GO:0001934,GO:0002039,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006334,GO:0006338,GO:0006355,GO:0007257,GO:0008134,GO:0008625,GO:0016032,GO:0016604,GO:0016605,GO:0019899,GO:0019901,GO:0030295,GO:0030521,GO:0031072,GO:0031396,GO:0031625,GO:0034605,GO:0034620,GO:0042393,GO:0042981,GO:0045860,GO:0045892,GO:0045893,GO:0047485,GO:0050681,GO:0071276,GO:0071280,GO:0072738,GO:0140037,GO:0140416,GO:1901216,GO:1903936" "chromosome, centromeric region|positive regulation of protein phosphorylation|p53 binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|nucleosome assembly|chromatin remodeling|regulation of transcription, DNA-templated|activation of JUN kinase activity|transcription factor binding|extrinsic apoptotic signaling pathway via death domain receptors|viral process|nuclear body|PML body|enzyme binding|protein kinase binding|protein kinase activator activity|androgen receptor signaling pathway|heat shock protein binding|regulation of protein ubiquitination|ubiquitin protein ligase binding|cellular response to heat|cellular response to unfolded protein|histone binding|regulation of apoptotic process|positive regulation of protein kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein N-terminus binding|androgen receptor binding|cellular response to cadmium ion|cellular response to copper ion|cellular response to diamide|sumo-dependent protein binding|transcription regulator inhibitor activity|positive regulation of neuron death|cellular response to sodium arsenite" "hsa04010,hsa04210,hsa05012,hsa05014,hsa05022,hsa05168" MAPK signaling pathway|Apoptosis|Parkinson disease|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Herpes simplex virus 1 infection DAZAP1 2211.363534 2226.485709 2196.241359 0.986416104 -0.019731741 0.935475434 1 25.42765893 24.66253474 26528 DAZ associated protein 1 "GO:0001893,GO:0003723,GO:0003730,GO:0005515,GO:0005654,GO:0005829,GO:0007283,GO:0008266,GO:0008283,GO:0030154,GO:0032991,GO:0034046,GO:0035613,GO:0048026,GO:1990904" "maternal placenta development|RNA binding|mRNA 3'-UTR binding|protein binding|nucleoplasm|cytosol|spermatogenesis|poly(U) RNA binding|cell population proliferation|cell differentiation|protein-containing complex|poly(G) binding|RNA stem-loop binding|positive regulation of mRNA splicing, via spliceosome|ribonucleoprotein complex" hsa03015 mRNA surveillance pathway DAZAP2 4357.711261 4297.949749 4417.472774 1.027809312 0.039572628 0.869235801 1 85.45964188 86.36639559 9802 DAZ associated protein 2 "GO:0005515,GO:0005737,GO:0016607,GO:0030971,GO:0031435,GO:0032991,GO:0042802,GO:0043539,GO:0050699,GO:0071902" protein binding|cytoplasm|nuclear speck|receptor tyrosine kinase binding|mitogen-activated protein kinase kinase kinase binding|protein-containing complex|identical protein binding|protein serine/threonine kinase activator activity|WW domain binding|positive regulation of protein serine/threonine kinase activity DBF4 747.7203129 742.8555122 752.5851135 1.013097569 0.018773123 0.94674281 1 11.12681262 11.08391601 10926 DBF4 zinc finger "GO:0000082,GO:0003676,GO:0005515,GO:0005634,GO:0005654,GO:0006260,GO:0008047,GO:0008270,GO:0010571,GO:0016604,GO:0031431,GO:0043539,GO:0071902,GO:1901987" G1/S transition of mitotic cell cycle|nucleic acid binding|protein binding|nucleus|nucleoplasm|DNA replication|enzyme activator activity|zinc ion binding|positive regulation of nuclear cell cycle DNA replication|nuclear body|Dbf4-dependent protein kinase complex|protein serine/threonine kinase activator activity|positive regulation of protein serine/threonine kinase activity|regulation of cell cycle phase transition hsa04110 Cell cycle DBF4B 698.9240416 786.5528953 611.295188 0.777182554 -0.363674579 0.15575829 1 10.08817169 7.709153382 80174 DBF4 zinc finger B "GO:0000785,GO:0003676,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007049,GO:0008270,GO:0008284,GO:0010571,GO:0010971,GO:0019901,GO:0030295,GO:0031431,GO:0032147,GO:0043231,GO:0043539,GO:0071902,GO:1901987" chromatin|nucleic acid binding|protein binding|nucleus|nucleoplasm|cytoplasm|cell cycle|zinc ion binding|positive regulation of cell population proliferation|positive regulation of nuclear cell cycle DNA replication|positive regulation of G2/M transition of mitotic cell cycle|protein kinase binding|protein kinase activator activity|Dbf4-dependent protein kinase complex|activation of protein kinase activity|intracellular membrane-bounded organelle|protein serine/threonine kinase activator activity|positive regulation of protein serine/threonine kinase activity|regulation of cell cycle phase transition DBI 1337.956931 1123.646993 1552.266869 1.38145421 0.466187743 0.052393878 1 44.88546022 60.96960132 1622 "diazepam binding inhibitor, acyl-CoA binding protein" "GO:0005788,GO:0005794,GO:0006637,GO:0008289,GO:0030156,GO:0032994,GO:0036042,GO:0036151,GO:0042802,GO:0070062,GO:1903060,GO:1905920,GO:2001140" endoplasmic reticulum lumen|Golgi apparatus|acyl-CoA metabolic process|lipid binding|benzodiazepine receptor binding|protein-lipid complex|long-chain fatty acyl-CoA binding|phosphatidylcholine acyl-chain remodeling|identical protein binding|extracellular exosome|negative regulation of protein lipidation|positive regulation of CoA-transferase activity|positive regulation of phospholipid transport hsa03320 PPAR signaling pathway DBN1 3091.490011 3051.533918 3131.446105 1.026187547 0.037294423 0.876142534 1 35.99000148 36.3144761 1627 drebrin 1 "GO:0001701,GO:0003779,GO:0005515,GO:0005522,GO:0005737,GO:0005856,GO:0005884,GO:0005886,GO:0005921,GO:0007015,GO:0010643,GO:0010644,GO:0014069,GO:0015629,GO:0030027,GO:0030425,GO:0030426,GO:0030427,GO:0030833,GO:0030863,GO:0030864,GO:0031915,GO:0032507,GO:0042641,GO:0045211,GO:0045296,GO:0045773,GO:0048168,GO:0048812,GO:0050773,GO:0051015,GO:0051220,GO:0061003,GO:0061351,GO:0098974,GO:0098978,GO:0099524,GO:1902685" in utero embryonic development|actin binding|protein binding|profilin binding|cytoplasm|cytoskeleton|actin filament|plasma membrane|gap junction|actin filament organization|cell communication by chemical coupling|cell communication by electrical coupling|postsynaptic density|actin cytoskeleton|lamellipodium|dendrite|growth cone|site of polarized growth|regulation of actin filament polymerization|cortical cytoskeleton|cortical actin cytoskeleton|positive regulation of synaptic plasticity|maintenance of protein location in cell|actomyosin|postsynaptic membrane|cadherin binding|positive regulation of axon extension|regulation of neuronal synaptic plasticity|neuron projection morphogenesis|regulation of dendrite development|actin filament binding|cytoplasmic sequestering of protein|positive regulation of dendritic spine morphogenesis|neural precursor cell proliferation|postsynaptic actin cytoskeleton organization|glutamatergic synapse|postsynaptic cytosol|positive regulation of receptor localization to synapse DBNDD1 250.3994051 252.8205735 247.9782366 0.980846745 -0.027900358 0.946452502 1 5.23576614 5.049548805 79007 dysbindin domain containing 1 "GO:0005737,GO:0006469" cytoplasm|negative regulation of protein kinase activity DBNDD2 954.7343362 929.0895972 980.3790751 1.055204017 0.077521962 0.756844103 1 27.06539531 28.08160907 55861 dysbindin domain containing 2 "GO:0005515,GO:0005737,GO:0006469" protein binding|cytoplasm|negative regulation of protein kinase activity DBNL 2204.744883 2153.656737 2255.833029 1.047443165 0.066871964 0.778762168 1 11.61446057 11.96191438 28988 drebrin like "GO:0000139,GO:0001726,GO:0002102,GO:0002250,GO:0003779,GO:0005515,GO:0005576,GO:0005737,GO:0005769,GO:0005829,GO:0005884,GO:0005886,GO:0005938,GO:0006898,GO:0007257,GO:0007416,GO:0008022,GO:0008047,GO:0014069,GO:0016601,GO:0019904,GO:0030027,GO:0030425,GO:0030427,GO:0030665,GO:0030833,GO:0030864,GO:0034774,GO:0043204,GO:0043312,GO:0045211,GO:0045296,GO:0045773,GO:0048812,GO:0051015,GO:0061003,GO:0070062,GO:0071800,GO:0097178,GO:0098974,GO:1904724,GO:1904813" Golgi membrane|ruffle|podosome|adaptive immune response|actin binding|protein binding|extracellular region|cytoplasm|early endosome|cytosol|actin filament|plasma membrane|cell cortex|receptor-mediated endocytosis|activation of JUN kinase activity|synapse assembly|protein C-terminus binding|enzyme activator activity|postsynaptic density|Rac protein signal transduction|protein domain specific binding|lamellipodium|dendrite|site of polarized growth|clathrin-coated vesicle membrane|regulation of actin filament polymerization|cortical actin cytoskeleton|secretory granule lumen|perikaryon|neutrophil degranulation|postsynaptic membrane|cadherin binding|positive regulation of axon extension|neuron projection morphogenesis|actin filament binding|positive regulation of dendritic spine morphogenesis|extracellular exosome|podosome assembly|ruffle assembly|postsynaptic actin cytoskeleton organization|tertiary granule lumen|ficolin-1-rich granule lumen DBP 80.54840194 70.74814402 90.34865986 1.277046361 0.352810901 0.494440932 1 1.739953187 2.184818711 1628 D-box binding PAR bZIP transcription factor "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001889,GO:0005634,GO:0006357,GO:0007623,GO:0045944,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|liver development|nucleus|regulation of transcription by RNA polymerase II|circadian rhythm|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" TF_bZIP DBR1 437.6499806 487.954111 387.3458503 0.793816143 -0.333123194 0.238454535 1 9.782574786 7.635619557 51163 debranching RNA lariats 1 "GO:0000375,GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0008419,GO:0046872,GO:0090502" "RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|RNA lariat debranching enzyme activity|metal ion binding|RNA phosphodiester bond hydrolysis, endonucleolytic" DBT 541.9398179 576.389291 507.4903448 0.880464562 -0.183663157 0.496401897 1 2.805110077 2.428471257 1629 dihydrolipoamide branched chain transacylase E2 "GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005947,GO:0009083,GO:0015630,GO:0016407,GO:0031405,GO:0031625,GO:0042645,GO:0043754" cytoplasm|mitochondrion|mitochondrial matrix|cytosol|mitochondrial alpha-ketoglutarate dehydrogenase complex|branched-chain amino acid catabolic process|microtubule cytoskeleton|acetyltransferase activity|lipoic acid binding|ubiquitin protein ligase binding|mitochondrial nucleoid|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity "hsa00280,hsa00640" "Valine, leucine and isoleucine degradation|Propanoate metabolism" DCAF1 1009.444769 1116.364096 902.5254427 0.808450797 -0.306768123 0.211699814 1 6.303247992 5.010593446 9730 DDB1 and CUL4 associated factor 1 "GO:0000122,GO:0001650,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0008180,GO:0016032,GO:0016567,GO:0030183,GO:0030331,GO:0033151,GO:0035212,GO:0080008,GO:0106310,GO:0106311,GO:1990244,GO:1990245" negative regulation of transcription by RNA polymerase II|fibrillar center|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|COP9 signalosome|viral process|protein ubiquitination|B cell differentiation|estrogen receptor binding|V(D)J recombination|cell competition in a multicellular organism|Cul4-RING E3 ubiquitin ligase complex|protein serine kinase activity|protein threonine kinase activity|histone kinase activity (H2A-T120 specific)|histone H2A-T120 phosphorylation hsa05170 Human immunodeficiency virus 1 infection DCAF10 1384.813956 1420.16495 1349.462962 0.950215651 -0.073673125 0.760842702 1 9.287047325 8.677028354 79269 DDB1 and CUL4 associated factor 10 "GO:0005515,GO:0005654,GO:0016567,GO:0043687,GO:0080008" protein binding|nucleoplasm|protein ubiquitination|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF11 1030.125328 977.9890497 1082.261606 1.10661935 0.146159056 0.552865333 1 12.94481104 14.08526927 80344 DDB1 and CUL4 associated factor 11 "GO:0005515,GO:0005654,GO:0016567,GO:0043161,GO:0043687,GO:0080008" protein binding|nucleoplasm|protein ubiquitination|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF12 1153.796186 1171.506032 1136.08634 0.969765677 -0.044291902 0.858628776 1 16.28578374 15.52911303 25853 DDB1 and CUL4 associated factor 12 "GO:0005515,GO:0005737,GO:0005813,GO:0016567,GO:0080008" protein binding|cytoplasm|centrosome|protein ubiquitination|Cul4-RING E3 ubiquitin ligase complex DCAF13 1502.253006 1475.306886 1529.199126 1.036529512 0.051761193 0.830748201 1 39.96670913 40.73345423 25879 DDB1 and CUL4 associated factor 13 "GO:0000462,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005813,GO:0005829,GO:0006364,GO:0016567,GO:0030054,GO:0030331,GO:0032040,GO:0043687,GO:0080008" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|protein binding|nucleoplasm|nucleolus|centrosome|cytosol|rRNA processing|protein ubiquitination|cell junction|estrogen receptor binding|small-subunit processome|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex" DCAF15 638.0799512 614.8846046 661.2752977 1.075446178 0.104935325 0.690742084 1 14.51360515 15.34741238 90379 DDB1 and CUL4 associated factor 15 "GO:0000209,GO:0002376,GO:0005515,GO:0016567,GO:0032814,GO:0036094,GO:0046872,GO:0080008" protein polyubiquitination|immune system process|protein binding|protein ubiquitination|regulation of natural killer cell activation|small molecule binding|metal ion binding|Cul4-RING E3 ubiquitin ligase complex DCAF16 2108.658855 2179.667084 2037.650627 0.934844886 -0.097201089 0.682234297 1 20.84674305 19.16235796 54876 DDB1 and CUL4 associated factor 16 "GO:0005515,GO:0005654,GO:0016567,GO:0043687,GO:0080008" protein binding|nucleoplasm|protein ubiquitination|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF17 524.8969061 532.6919079 517.1019043 0.970733545 -0.042852747 0.880968671 1 4.260909484 4.066993934 80067 DDB1 and CUL4 associated factor 17 "GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0016021,GO:0016567,GO:0043687,GO:0080008" protein binding|nucleoplasm|nucleolus|cytosol|integral component of membrane|protein ubiquitination|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF4 639.7493981 646.0970211 633.401775 0.980350867 -0.028629913 0.918534547 1 11.78837967 11.3633617 26094 DDB1 and CUL4 associated factor 4 "GO:0005515,GO:0005654,GO:0016567,GO:0043687,GO:0080008" protein binding|nucleoplasm|protein ubiquitination|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF4L1 2.561405743 4.161655531 0.961155956 0.230955193 -2.11431511 0.482263142 1 0.04715497 0.010708444 285429 DDB1 and CUL4 associated factor 4 like 1 DCAF5 1418.141799 1500.276819 1336.006779 0.890506847 -0.167301392 0.485435541 1 9.686307334 8.481383206 8816 DDB1 and CUL4 associated factor 5 "GO:0005515,GO:0005654,GO:0005737,GO:0016567,GO:0043687,GO:0080008" protein binding|nucleoplasm|cytoplasm|protein ubiquitination|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF6 1329.031698 1507.559716 1150.503679 0.76315629 -0.389949553 0.104592894 1 22.15799814 16.62704944 55827 DDB1 and CUL4 associated factor 6 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005925,GO:0016567,GO:0030374,GO:0043687,GO:0045944,GO:0080008" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|focal adhesion|protein ubiquitination|nuclear receptor coactivator activity|post-translational protein modification|positive regulation of transcription by RNA polymerase II|Cul4-RING E3 ubiquitin ligase complex DCAF7 4107.925798 4111.715664 4104.135932 0.998156552 -0.002661987 0.992246343 1 34.69872043 34.05518943 10238 DDB1 and CUL4 associated factor 7 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007275,GO:0016363,GO:0016567,GO:0016604,GO:0030674,GO:0032991,GO:0043687,GO:0080008" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|multicellular organism development|nuclear matrix|protein ubiquitination|nuclear body|protein-macromolecule adaptor activity|protein-containing complex|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF8 2483.363796 2541.731115 2424.996477 0.954072782 -0.067828767 0.775424599 1 35.0782307 32.90715714 50717 DDB1 and CUL4 associated factor 8 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0016567,GO:0043687,GO:0080008" protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|protein ubiquitination|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF8L2 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.012613579 0.034373084 347442 DDB1 and CUL4 associated factor 8 like 2 "GO:0005737,GO:0080008" cytoplasm|Cul4-RING E3 ubiquitin ligase complex DCAKD 321.2274214 295.4775427 346.9773001 1.174293305 0.231792797 0.455335256 1 4.717048575 5.446507575 79877 dephospho-CoA kinase domain containing "GO:0004140,GO:0005524,GO:0015937,GO:0016020,GO:0016310" dephospho-CoA kinase activity|ATP binding|coenzyme A biosynthetic process|membrane|phosphorylation DCBLD1 698.9737314 762.623376 635.3240869 0.833077122 -0.263478037 0.30444415 1 9.565172252 7.835183674 285761 "discoidin, CUB and LCCL domain containing 1" GO:0016021 integral component of membrane DCBLD2 15953.86683 18588.03443 13319.69924 0.716573842 -0.480812716 0.069726628 1 158.6199607 111.7609196 131566 "discoidin, CUB and LCCL domain containing 2" "GO:0005515,GO:0005887,GO:0009986,GO:0030308,GO:0030522,GO:0042060" protein binding|integral component of plasma membrane|cell surface|negative regulation of cell growth|intracellular receptor signaling pathway|wound healing DCDC1 6.445658531 5.202069413 7.689247648 1.478113235 0.563756795 0.78195947 1 0.01668118 0.024244077 341019 doublecortin domain containing 1 "GO:0005515,GO:0005737,GO:0005874,GO:0007049,GO:0008017,GO:0030246,GO:0030496,GO:0035556,GO:0051301,GO:0072686,GO:0090543,GO:1902412" protein binding|cytoplasm|microtubule|cell cycle|microtubule binding|carbohydrate binding|midbody|intracellular signal transduction|cell division|mitotic spindle|Flemming body|regulation of mitotic cytokinesis DCDC2 9.566900179 11.44455271 7.689247648 0.671869652 -0.573746729 0.681462136 1 0.12653299 0.083591087 51473 doublecortin domain containing 2 "GO:0001764,GO:0005515,GO:0005654,GO:0005737,GO:0005815,GO:0005829,GO:0005874,GO:0005929,GO:0005930,GO:0006968,GO:0007605,GO:0015630,GO:0019894,GO:0030111,GO:0030864,GO:0034451,GO:0035556,GO:0045880,GO:0048813,GO:0060091,GO:0060271,GO:0072686,GO:1902017" neuron migration|protein binding|nucleoplasm|cytoplasm|microtubule organizing center|cytosol|microtubule|cilium|axoneme|cellular defense response|sensory perception of sound|microtubule cytoskeleton|kinesin binding|regulation of Wnt signaling pathway|cortical actin cytoskeleton|centriolar satellite|intracellular signal transduction|positive regulation of smoothened signaling pathway|dendrite morphogenesis|kinocilium|cilium assembly|mitotic spindle|regulation of cilium assembly DCDC2C 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.038390166 0 728597 doublecortin domain containing 2C "GO:0005737,GO:0005815,GO:0005874,GO:0030864,GO:0035556,GO:0036126" cytoplasm|microtubule organizing center|microtubule|cortical actin cytoskeleton|intracellular signal transduction|sperm flagellum DCHS1 17.09260156 19.76786377 14.41733934 0.729332188 -0.455352028 0.654677017 1 0.098476109 0.070619956 8642 dachsous cadherin-related 1 "GO:0000902,GO:0001658,GO:0003192,GO:0003273,GO:0005509,GO:0005912,GO:0007043,GO:0007156,GO:0007157,GO:0007275,GO:0007389,GO:0016020,GO:0016021,GO:0016339,GO:0016342,GO:0021915,GO:0022008,GO:0034332,GO:0035329,GO:0036342,GO:0043931,GO:0045177,GO:0045296,GO:0048565,GO:0072137,GO:0072659,GO:0090102,GO:0098742" cell morphogenesis|branching involved in ureteric bud morphogenesis|mitral valve formation|cell migration involved in endocardial cushion formation|calcium ion binding|adherens junction|cell-cell junction assembly|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|multicellular organism development|pattern specification process|membrane|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|neural tube development|neurogenesis|adherens junction organization|hippo signaling|post-anal tail morphogenesis|ossification involved in bone maturation|apical part of cell|cadherin binding|digestive tract development|condensed mesenchymal cell proliferation|protein localization to plasma membrane|cochlea development|cell-cell adhesion via plasma-membrane adhesion molecules hsa04392 Hippo signaling pathway - multiple species DCHS2 14.05061783 15.60620824 12.49502743 0.800644669 -0.320765987 0.805610112 1 0.053585193 0.04218478 54798 dachsous cadherin-related 2 "GO:0003674,GO:0005509,GO:0005575,GO:0005886,GO:0007156,GO:0008150,GO:0016021,GO:0072006,GO:0072137" molecular_function|calcium ion binding|cellular_component|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|biological_process|integral component of membrane|nephron development|condensed mesenchymal cell proliferation hsa04392 Hippo signaling pathway - multiple species DCK 1291.11254 1193.354723 1388.870356 1.163836979 0.218888991 0.363856844 1 25.41386604 29.08265605 1633 deoxycytidine kinase "GO:0004136,GO:0004137,GO:0004138,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006170,GO:0006220,GO:0008144,GO:0016310,GO:0019136,GO:0042803,GO:0043097,GO:0043101" deoxyadenosine kinase activity|deoxycytidine kinase activity|deoxyguanosine kinase activity|ATP binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|dAMP biosynthetic process|pyrimidine nucleotide metabolic process|drug binding|phosphorylation|deoxynucleoside kinase activity|protein homodimerization activity|pyrimidine nucleoside salvage|purine-containing compound salvage "hsa00230,hsa00240" Purine metabolism|Pyrimidine metabolism DCLK1 30.10783592 20.80827765 39.4073942 1.893832582 0.9213088 0.20820036 1 0.081462701 0.151695105 9201 doublecortin like kinase 1 "GO:0001764,GO:0004672,GO:0005524,GO:0005887,GO:0006468,GO:0007399,GO:0007417,GO:0009615,GO:0014069,GO:0016197,GO:0018105,GO:0021952,GO:0030900,GO:0035556,GO:0048675,GO:0048812,GO:0048813,GO:0106310,GO:0106311,GO:1900181" neuron migration|protein kinase activity|ATP binding|integral component of plasma membrane|protein phosphorylation|nervous system development|central nervous system development|response to virus|postsynaptic density|endosomal transport|peptidyl-serine phosphorylation|central nervous system projection neuron axonogenesis|forebrain development|intracellular signal transduction|axon extension|neuron projection morphogenesis|dendrite morphogenesis|protein serine kinase activity|protein threonine kinase activity|negative regulation of protein localization to nucleus DCLK2 83.58032483 99.87973273 67.28091692 0.673619313 -0.569994594 0.254394608 1 1.153017038 0.763697613 166614 doublecortin like kinase 2 "GO:0000226,GO:0005524,GO:0005737,GO:0005856,GO:0006468,GO:0035556,GO:0106310,GO:0106311" microtubule cytoskeleton organization|ATP binding|cytoplasm|cytoskeleton|protein phosphorylation|intracellular signal transduction|protein serine kinase activity|protein threonine kinase activity DCLRE1A 343.0163623 388.0743782 297.9583464 0.7677867 -0.381222525 0.207192436 1 4.435814161 3.348768351 9937 DNA cross-link repair 1A "GO:0001650,GO:0003684,GO:0005654,GO:0006303,GO:0007049,GO:0031848,GO:0035312,GO:0036297,GO:0046872,GO:0051301,GO:0090305" fibrillar center|damaged DNA binding|nucleoplasm|double-strand break repair via nonhomologous end joining|cell cycle|protection from non-homologous end joining at telomere|5'-3' exodeoxyribonuclease activity|interstrand cross-link repair|metal ion binding|cell division|nucleic acid phosphodiester bond hydrolysis DCLRE1B 974.9381185 980.0698774 969.8063596 0.989527769 -0.0151879 0.955376591 1 14.75028992 14.35158018 64858 DNA cross-link repair 1B "GO:0000723,GO:0000781,GO:0003684,GO:0005515,GO:0005654,GO:0005737,GO:0005813,GO:0006303,GO:0007093,GO:0008409,GO:0010833,GO:0016233,GO:0016604,GO:0031627,GO:0031848,GO:0031860,GO:0035312,GO:0036297,GO:0042803,GO:0044877,GO:0090305" "telomere maintenance|chromosome, telomeric region|damaged DNA binding|protein binding|nucleoplasm|cytoplasm|centrosome|double-strand break repair via nonhomologous end joining|mitotic cell cycle checkpoint|5'-3' exonuclease activity|telomere maintenance via telomere lengthening|telomere capping|nuclear body|telomeric loop formation|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|5'-3' exodeoxyribonuclease activity|interstrand cross-link repair|protein homodimerization activity|protein-containing complex binding|nucleic acid phosphodiester bond hydrolysis" DCLRE1C 428.9303799 460.90335 396.9574098 0.861259546 -0.215480027 0.450296378 1 2.850239245 2.413718075 64421 DNA cross-link repair 1C "GO:0000014,GO:0002250,GO:0003684,GO:0004519,GO:0005515,GO:0005654,GO:0005794,GO:0006303,GO:0008409,GO:0010212,GO:0030183,GO:0031848,GO:0033151,GO:0035312,GO:0036297,GO:0070419,GO:0090305" single-stranded DNA endodeoxyribonuclease activity|adaptive immune response|damaged DNA binding|endonuclease activity|protein binding|nucleoplasm|Golgi apparatus|double-strand break repair via nonhomologous end joining|5'-3' exonuclease activity|response to ionizing radiation|B cell differentiation|protection from non-homologous end joining at telomere|V(D)J recombination|5'-3' exodeoxyribonuclease activity|interstrand cross-link repair|nonhomologous end joining complex|nucleic acid phosphodiester bond hydrolysis "hsa03450,hsa05340" Non-homologous end-joining|Primary immunodeficiency DCP1A 1166.478683 1302.598181 1030.359185 0.791003089 -0.338244766 0.163291756 1 11.62301803 9.039996651 55802 decapping mRNA 1A "GO:0000184,GO:0000290,GO:0000932,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0008047,GO:0016020,GO:0016787,GO:0019894,GO:0030234,GO:0031087,GO:0036464,GO:0042802,GO:0043085,GO:0043488,GO:0043928,GO:1903608" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|mRNA binding|protein binding|nucleus|cytoplasm|cytosol|enzyme activator activity|membrane|hydrolase activity|kinesin binding|enzyme regulator activity|deadenylation-independent decapping of nuclear-transcribed mRNA|cytoplasmic ribonucleoprotein granule|identical protein binding|positive regulation of catalytic activity|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|protein localization to cytoplasmic stress granule" hsa03018 RNA degradation DCP1B 223.8833279 263.2247123 184.5419436 0.701081376 -0.512346184 0.14124793 1 3.541169425 2.441104183 196513 decapping mRNA 1B "GO:0000184,GO:0000290,GO:0000932,GO:0003729,GO:0005515,GO:0005634,GO:0005829,GO:0008047,GO:0016020,GO:0016787,GO:0030234,GO:0031087,GO:0043085,GO:0043231,GO:0043928" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|mRNA binding|protein binding|nucleus|cytosol|enzyme activator activity|membrane|hydrolase activity|enzyme regulator activity|deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of catalytic activity|intracellular membrane-bounded organelle|exonucleolytic catabolism of deadenylated mRNA" hsa03018 RNA degradation DCP2 1081.333936 1010.24188 1152.425991 1.140742642 0.189973348 0.437580037 1 5.239528901 5.87693781 167227 decapping mRNA 2 "GO:0000184,GO:0000290,GO:0000932,GO:0004534,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006402,GO:0016442,GO:0016896,GO:0030054,GO:0030145,GO:0032211,GO:0036464,GO:0043488,GO:0043928,GO:0050072,GO:0070034,GO:0071044,GO:0090503,GO:1904872" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|5'-3' exoribonuclease activity|protein binding|nucleoplasm|cytoplasm|cytosol|mRNA catabolic process|RISC complex|exoribonuclease activity, producing 5'-phosphomonoesters|cell junction|manganese ion binding|negative regulation of telomere maintenance via telomerase|cytoplasmic ribonucleoprotein granule|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|m7G(5')pppN diphosphatase activity|telomerase RNA binding|histone mRNA catabolic process|RNA phosphodiester bond hydrolysis, exonucleolytic|regulation of telomerase RNA localization to Cajal body" hsa03018 RNA degradation DCPS 504.1924241 531.651494 476.7333542 0.896702745 -0.15729828 0.567703149 1 5.228167146 4.60966263 28960 "decapping enzyme, scavenger" "GO:0000288,GO:0000290,GO:0000340,GO:0000932,GO:0004532,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0036245,GO:0042802,GO:0043069,GO:0043928,GO:0045292,GO:0050072,GO:0090503" "nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|deadenylation-dependent decapping of nuclear-transcribed mRNA|RNA 7-methylguanosine cap binding|P-body|exoribonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|cellular response to menadione|identical protein binding|negative regulation of programmed cell death|exonucleolytic catabolism of deadenylated mRNA|mRNA cis splicing, via spliceosome|m7G(5')pppN diphosphatase activity|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation DCST1 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.072518472 0 149095 DC-STAMP domain containing 1 "GO:0005515,GO:0005886,GO:0006511,GO:0016021,GO:0016567,GO:0045087,GO:0046872,GO:0060339,GO:0061630" protein binding|plasma membrane|ubiquitin-dependent protein catabolic process|integral component of membrane|protein ubiquitination|innate immune response|metal ion binding|negative regulation of type I interferon-mediated signaling pathway|ubiquitin protein ligase activity DCST2 7.124381325 10.40413883 3.844623824 0.369528309 -1.436243205 0.311438224 1 0.172759728 0.062771341 127579 DC-STAMP domain containing 2 GO:0016021 integral component of membrane DCT 6.604174384 9.363724944 3.844623824 0.41058701 -1.284240111 0.3924594 1 0.092627394 0.037395197 1638 dopachrome tautomerase "GO:0002052,GO:0004167,GO:0005507,GO:0005515,GO:0005829,GO:0005886,GO:0006583,GO:0008544,GO:0009637,GO:0016021,GO:0016491,GO:0021847,GO:0033162,GO:0042438,GO:0042470,GO:0043231,GO:0048066,GO:0048468,GO:0055114" positive regulation of neuroblast proliferation|dopachrome isomerase activity|copper ion binding|protein binding|cytosol|plasma membrane|melanin biosynthetic process from tyrosine|epidermis development|response to blue light|integral component of membrane|oxidoreductase activity|ventricular zone neuroblast division|melanosome membrane|melanin biosynthetic process|melanosome|intracellular membrane-bounded organelle|developmental pigmentation|cell development|oxidation-reduction process "hsa00350,hsa04916" Tyrosine metabolism|Melanogenesis DCTD 1589.267188 1501.317233 1677.217143 1.117163719 0.159840627 0.502811123 1 29.60921707 32.52482179 1635 dCMP deaminase "GO:0004132,GO:0005515,GO:0005829,GO:0006220,GO:0006226,GO:0006231,GO:0008270,GO:0015949,GO:0042802" dCMP deaminase activity|protein binding|cytosol|pyrimidine nucleotide metabolic process|dUMP biosynthetic process|dTMP biosynthetic process|zinc ion binding|nucleobase-containing small molecule interconversion|identical protein binding hsa00240 Pyrimidine metabolism DCTN1 3499.190672 3522.841407 3475.539937 0.986572921 -0.019502405 0.935752543 1 38.72452547 37.5652665 1639 dynactin subunit 1 "GO:0000086,GO:0000132,GO:0000278,GO:0000776,GO:0000922,GO:0003774,GO:0005515,GO:0005634,GO:0005635,GO:0005737,GO:0005813,GO:0005814,GO:0005819,GO:0005829,GO:0005874,GO:0005875,GO:0005938,GO:0006888,GO:0007097,GO:0007399,GO:0007528,GO:0008017,GO:0010389,GO:0010457,GO:0015630,GO:0015631,GO:0016020,GO:0019886,GO:0019901,GO:0021517,GO:0030286,GO:0030424,GO:0030904,GO:0031116,GO:0031122,GO:0034454,GO:0035371,GO:0036498,GO:0042147,GO:0043005,GO:0043025,GO:0045171,GO:0048156,GO:0050905,GO:0051010,GO:0051081,GO:0051301,GO:0060236,GO:0061744,GO:0070050,GO:0072686,GO:0090063,GO:0097711,GO:0098930,GO:0099558,GO:0099738,GO:0120103,GO:1904398,GO:1905515,GO:1990535" "G2/M transition of mitotic cell cycle|establishment of mitotic spindle orientation|mitotic cell cycle|kinetochore|spindle pole|motor activity|protein binding|nucleus|nuclear envelope|cytoplasm|centrosome|centriole|spindle|cytosol|microtubule|microtubule associated complex|cell cortex|endoplasmic reticulum to Golgi vesicle-mediated transport|nuclear migration|nervous system development|neuromuscular junction development|microtubule binding|regulation of G2/M transition of mitotic cell cycle|centriole-centriole cohesion|microtubule cytoskeleton|tubulin binding|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|ventral spinal cord development|dynein complex|axon|retromer complex|positive regulation of microtubule polymerization|cytoplasmic microtubule organization|microtubule anchoring at centrosome|microtubule plus-end|IRE1-mediated unfolded protein response|retrograde transport, endosome to Golgi|neuron projection|neuronal cell body|intercellular bridge|tau protein binding|neuromuscular process|microtubule plus-end binding|nuclear envelope disassembly|cell division|regulation of mitotic spindle organization|motor behavior|neuron cellular homeostasis|mitotic spindle|positive regulation of microtubule nucleation|ciliary basal body-plasma membrane docking|axonal transport|maintenance of synapse structure|cell cortex region|centriolar subdistal appendage|positive regulation of neuromuscular junction development|non-motile cilium assembly|neuron projection maintenance" "hsa04962,hsa05014,hsa05016,hsa05022,hsa05132" Vasopressin-regulated water reabsorption|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection DCTN2 3380.029912 3069.220954 3690.838871 1.202532801 0.266076247 0.262025385 1 65.72980791 77.71958502 10540 dynactin subunit 2 "GO:0000086,GO:0000776,GO:0003774,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005869,GO:0005874,GO:0006888,GO:0007052,GO:0007080,GO:0010389,GO:0016020,GO:0019886,GO:0019901,GO:0030286,GO:0030426,GO:0030507,GO:0031982,GO:0032402,GO:0042802,GO:0070062,GO:0071539,GO:0097711" G2/M transition of mitotic cell cycle|kinetochore|motor activity|protein binding|cytoplasm|centrosome|cytosol|dynactin complex|microtubule|endoplasmic reticulum to Golgi vesicle-mediated transport|mitotic spindle organization|mitotic metaphase plate congression|regulation of G2/M transition of mitotic cell cycle|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|dynein complex|growth cone|spectrin binding|vesicle|melanosome transport|identical protein binding|extracellular exosome|protein localization to centrosome|ciliary basal body-plasma membrane docking "hsa04962,hsa05014,hsa05016,hsa05022,hsa05132" Vasopressin-regulated water reabsorption|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection DCTN3 1011.967775 917.6450445 1106.290505 1.205575633 0.269722163 0.27239439 1 52.94381564 62.75970269 11258 dynactin subunit 3 "GO:0000086,GO:0000278,GO:0000777,GO:0005198,GO:0005515,GO:0005730,GO:0005813,GO:0005819,GO:0005829,GO:0005869,GO:0005874,GO:0006888,GO:0007017,GO:0010389,GO:0019886,GO:0030496,GO:0032154,GO:0048471,GO:0061640,GO:0097711" G2/M transition of mitotic cell cycle|mitotic cell cycle|condensed chromosome kinetochore|structural molecule activity|protein binding|nucleolus|centrosome|spindle|cytosol|dynactin complex|microtubule|endoplasmic reticulum to Golgi vesicle-mediated transport|microtubule-based process|regulation of G2/M transition of mitotic cell cycle|antigen processing and presentation of exogenous peptide antigen via MHC class II|midbody|cleavage furrow|perinuclear region of cytoplasm|cytoskeleton-dependent cytokinesis|ciliary basal body-plasma membrane docking "hsa05014,hsa05016,hsa05022,hsa05132" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection DCTN4 2067.522878 2096.433974 2038.611783 0.972418788 -0.040350328 0.866432245 1 23.56420137 22.53083281 51164 dynactin subunit 4 "GO:0000776,GO:0000922,GO:0001725,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0005868,GO:0005869,GO:0005925,GO:0005938,GO:0006888,GO:0019886,GO:0030017,GO:0047485" kinetochore|spindle pole|stress fiber|protein binding|nucleus|cytoplasm|centrosome|cytosol|cytoplasmic dynein complex|dynactin complex|focal adhesion|cell cortex|endoplasmic reticulum to Golgi vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|sarcomere|protein N-terminus binding "hsa04962,hsa05014,hsa05016,hsa05022,hsa05132" Vasopressin-regulated water reabsorption|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection DCTN5 1897.770026 2068.342799 1727.197253 0.835063343 -0.260042458 0.272253345 1 9.70320444 7.967201119 84516 dynactin subunit 5 "GO:0000777,GO:0003281,GO:0005515,GO:0005654,GO:0005813,GO:0005829,GO:0006888,GO:0019886,GO:0031965,GO:0035904,GO:0060976" condensed chromosome kinetochore|ventricular septum development|protein binding|nucleoplasm|centrosome|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|nuclear membrane|aorta development|coronary vasculature development "hsa04962,hsa05014,hsa05016,hsa05022,hsa05132" Vasopressin-regulated water reabsorption|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection DCTN6 511.6092994 511.8836303 511.3349686 0.998928152 -0.00154718 1 1 25.91867983 25.45764981 10671 dynactin subunit 6 "GO:0000777,GO:0005813,GO:0005829,GO:0005869,GO:0006888,GO:0007052,GO:0019886,GO:0070840" condensed chromosome kinetochore|centrosome|cytosol|dynactin complex|endoplasmic reticulum to Golgi vesicle-mediated transport|mitotic spindle organization|antigen processing and presentation of exogenous peptide antigen via MHC class II|dynein complex binding "hsa04962,hsa05014,hsa05016,hsa05022,hsa05132" Vasopressin-regulated water reabsorption|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection DCTPP1 832.2422864 791.7549647 872.729608 1.102272353 0.140480734 0.577268222 1 35.77858364 38.77780635 79077 dCTP pyrophosphatase 1 "GO:0000287,GO:0005515,GO:0005634,GO:0005739,GO:0005829,GO:0006253,GO:0009143,GO:0032556,GO:0042262,GO:0042802,GO:0046076,GO:0047429,GO:0047840" magnesium ion binding|protein binding|nucleus|mitochondrion|cytosol|dCTP catabolic process|nucleoside triphosphate catabolic process|pyrimidine deoxyribonucleotide binding|DNA protection|identical protein binding|dTTP catabolic process|nucleoside-triphosphate diphosphatase activity|dCTP diphosphatase activity hsa00240 Pyrimidine metabolism DCUN1D1 767.7850867 840.6544172 694.9157562 0.826636656 -0.274674756 0.277850498 1 5.186011003 4.215210544 54165 defective in cullin neddylation 1 domain containing 1 "GO:0000151,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0031396,GO:0031624,GO:0032182,GO:0043687,GO:0045116,GO:0051443,GO:0097602,GO:2000434,GO:2000436" ubiquitin ligase complex|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of protein ubiquitination|ubiquitin conjugating enzyme binding|ubiquitin-like protein binding|post-translational protein modification|protein neddylation|positive regulation of ubiquitin-protein transferase activity|cullin family protein binding|regulation of protein neddylation|positive regulation of protein neddylation DCUN1D2 344.7505902 357.9023756 331.5988048 0.926506297 -0.110127313 0.722171167 1 2.216103027 2.018875329 55208 defective in cullin neddylation 1 domain containing 2 "GO:0000151,GO:0005515,GO:0005634,GO:0005737,GO:0031624,GO:0032182,GO:0045116,GO:0051443,GO:0097602,GO:2000434,GO:2000436" ubiquitin ligase complex|protein binding|nucleus|cytoplasm|ubiquitin conjugating enzyme binding|ubiquitin-like protein binding|protein neddylation|positive regulation of ubiquitin-protein transferase activity|cullin family protein binding|regulation of protein neddylation|positive regulation of protein neddylation DCUN1D3 327.5592235 285.0734038 370.0450431 1.298069333 0.376367443 0.219823854 1 2.479439964 3.164627992 123879 defective in cullin neddylation 1 domain containing 3 "GO:0000151,GO:0003674,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0010225,GO:0010332,GO:0010564,GO:0030308,GO:0031624,GO:0032182,GO:0043065,GO:0043687,GO:0045116,GO:0048471,GO:0051443,GO:0097602,GO:2000134,GO:2000434,GO:2000435,GO:2000436" ubiquitin ligase complex|molecular_function|protein binding|nucleus|cytoplasm|plasma membrane|response to UV-C|response to gamma radiation|regulation of cell cycle process|negative regulation of cell growth|ubiquitin conjugating enzyme binding|ubiquitin-like protein binding|positive regulation of apoptotic process|post-translational protein modification|protein neddylation|perinuclear region of cytoplasm|positive regulation of ubiquitin-protein transferase activity|cullin family protein binding|negative regulation of G1/S transition of mitotic cell cycle|regulation of protein neddylation|negative regulation of protein neddylation|positive regulation of protein neddylation DCUN1D4 761.3645802 773.0275148 749.7016457 0.969825305 -0.044203197 0.866378634 1 8.775804659 8.368577418 23142 defective in cullin neddylation 1 domain containing 4 "GO:0000151,GO:0005515,GO:0005634,GO:0031624,GO:0032182,GO:0045116,GO:0051443,GO:0097602,GO:2000436" ubiquitin ligase complex|protein binding|nucleus|ubiquitin conjugating enzyme binding|ubiquitin-like protein binding|protein neddylation|positive regulation of ubiquitin-protein transferase activity|cullin family protein binding|positive regulation of protein neddylation DCUN1D5 862.8011321 786.5528953 939.049369 1.193879489 0.255657218 0.306003694 1 3.100899933 3.640151185 84259 defective in cullin neddylation 1 domain containing 5 "GO:0000151,GO:0001558,GO:0005515,GO:0005634,GO:0005819,GO:0006974,GO:0031624,GO:0032182,GO:0045116,GO:0051443,GO:0097602,GO:2000434,GO:2000436" ubiquitin ligase complex|regulation of cell growth|protein binding|nucleus|spindle|cellular response to DNA damage stimulus|ubiquitin conjugating enzyme binding|ubiquitin-like protein binding|protein neddylation|positive regulation of ubiquitin-protein transferase activity|cullin family protein binding|regulation of protein neddylation|positive regulation of protein neddylation DCXR 530.4210377 538.9343912 521.9076841 0.968406716 -0.04631501 0.870408438 1 33.99756258 32.37253829 51181 dicarbonyl and L-xylulose reductase "GO:0004090,GO:0005515,GO:0005634,GO:0005881,GO:0005886,GO:0005902,GO:0005903,GO:0005997,GO:0006006,GO:0006739,GO:0016655,GO:0019640,GO:0042732,GO:0042802,GO:0044105,GO:0050038,GO:0055114,GO:0070062" "carbonyl reductase (NADPH) activity|protein binding|nucleus|cytoplasmic microtubule|plasma membrane|microvillus|brush border|xylulose metabolic process|glucose metabolic process|NADP metabolic process|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|glucuronate catabolic process to xylulose 5-phosphate|D-xylose metabolic process|identical protein binding|L-xylulose reductase (NAD+) activity|L-xylulose reductase (NADP+) activity|oxidation-reduction process|extracellular exosome" hsa00040 Pentose and glucuronate interconversions DDA1 726.4861775 664.824471 788.1478839 1.185497704 0.245492869 0.336281924 1 10.30809417 12.0157331 79016 DET1 and DDB1 associated 1 "GO:0000209,GO:0005515,GO:0005654,GO:0032436,GO:0043687,GO:0080008" protein polyubiquitination|protein binding|nucleoplasm|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DDAH1 2105.56338 2010.079621 2201.047139 1.095004952 0.130937394 0.580667359 1 20.20991994 21.75964746 23576 dimethylarginine dimethylaminohydrolase 1 "GO:0000052,GO:0003073,GO:0003824,GO:0005829,GO:0006525,GO:0006527,GO:0007263,GO:0008285,GO:0016403,GO:0016597,GO:0043116,GO:0045429,GO:0045766,GO:0046872,GO:0050999,GO:0070062,GO:1900038" citrulline metabolic process|regulation of systemic arterial blood pressure|catalytic activity|cytosol|arginine metabolic process|arginine catabolic process|nitric oxide mediated signal transduction|negative regulation of cell population proliferation|dimethylargininase activity|amino acid binding|negative regulation of vascular permeability|positive regulation of nitric oxide biosynthetic process|positive regulation of angiogenesis|metal ion binding|regulation of nitric-oxide synthase activity|extracellular exosome|negative regulation of cellular response to hypoxia DDAH2 425.898457 431.7717613 420.0251528 0.972794403 -0.039793167 0.897039438 1 12.44887376 11.90754701 23564 dimethylarginine dimethylaminohydrolase 2 "GO:0000052,GO:0003824,GO:0005515,GO:0005739,GO:0005829,GO:0006525,GO:0006527,GO:0006809,GO:0007263,GO:0016403,GO:0016597,GO:0043066,GO:0045429,GO:0050999,GO:0070062" citrulline metabolic process|catalytic activity|protein binding|mitochondrion|cytosol|arginine metabolic process|arginine catabolic process|nitric oxide biosynthetic process|nitric oxide mediated signal transduction|dimethylargininase activity|amino acid binding|negative regulation of apoptotic process|positive regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity|extracellular exosome DDB1 6148.299764 6000.066861 6296.532668 1.049410417 0.069579016 0.774613133 1 75.43287178 77.83540536 1642 damage specific DNA binding protein 1 "GO:0000715,GO:0000717,GO:0000781,GO:0003677,GO:0003684,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0006281,GO:0006283,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006511,GO:0006974,GO:0010498,GO:0016032,GO:0016567,GO:0030674,GO:0031461,GO:0031464,GO:0031465,GO:0032991,GO:0033683,GO:0035518,GO:0042769,GO:0043161,GO:0043687,GO:0044877,GO:0045070,GO:0045722,GO:0045732,GO:0046726,GO:0048511,GO:0051702,GO:0070062,GO:0070911,GO:0070914,GO:0071987,GO:0080008,GO:0097602,GO:1901990,GO:1902188" "nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|chromosome, telomeric region|DNA binding|damaged DNA binding|protein binding|extracellular space|nucleus|nucleoplasm|cytoplasm|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|proteasomal protein catabolic process|viral process|protein ubiquitination|protein-macromolecule adaptor activity|cullin-RING ubiquitin ligase complex|Cul4A-RING E3 ubiquitin ligase complex|Cul4B-RING E3 ubiquitin ligase complex|protein-containing complex|nucleotide-excision repair, DNA incision|histone H2A monoubiquitination|DNA damage response, detection of DNA damage|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|protein-containing complex binding|positive regulation of viral genome replication|positive regulation of gluconeogenesis|positive regulation of protein catabolic process|positive regulation by virus of viral protein levels in host cell|rhythmic process|biological process involved in interaction with symbiont|extracellular exosome|global genome nucleotide-excision repair|UV-damage excision repair|WD40-repeat domain binding|Cul4-RING E3 ubiquitin ligase complex|cullin family protein binding|regulation of mitotic cell cycle phase transition|positive regulation of viral release from host cell" "hsa03420,hsa04120,hsa05161,hsa05170,hsa05203" Nucleotide excision repair|Ubiquitin mediated proteolysis|Hepatitis B|Human immunodeficiency virus 1 infection|Viral carcinogenesis DDB2 580.5200343 542.0556329 618.9844357 1.141920493 0.191462206 0.471724759 1 15.93857458 17.89602281 1643 damage specific DNA binding protein 2 "GO:0000209,GO:0000715,GO:0000717,GO:0003677,GO:0003684,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006289,GO:0006290,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0009411,GO:0016579,GO:0030054,GO:0031465,GO:0032991,GO:0033683,GO:0035518,GO:0043687,GO:0044877,GO:0051865,GO:0070911,GO:0070914,GO:0080008" "protein polyubiquitination|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|DNA binding|damaged DNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|DNA repair|nucleotide-excision repair|pyrimidine dimer repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|response to UV|protein deubiquitination|cell junction|Cul4B-RING E3 ubiquitin ligase complex|protein-containing complex|nucleotide-excision repair, DNA incision|histone H2A monoubiquitination|post-translational protein modification|protein-containing complex binding|protein autoubiquitination|global genome nucleotide-excision repair|UV-damage excision repair|Cul4-RING E3 ubiquitin ligase complex" "hsa03420,hsa04115,hsa04120,hsa05161,hsa05169,hsa05200,hsa05202,hsa05210,hsa05212,hsa05213,hsa05214,hsa05216,hsa05217,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" Nucleotide excision repair|p53 signaling pathway|Ubiquitin mediated proteolysis|Hepatitis B|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Thyroid cancer|Basal cell carcinoma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer DDHD1 930.987256 1024.807674 837.1668377 0.816901413 -0.291766116 0.238548676 1 4.186474439 3.362708874 80821 DDHD domain containing 1 "GO:0004620,GO:0005515,GO:0005737,GO:0005829,GO:0006654,GO:0016042,GO:0046872,GO:0090141" phospholipase activity|protein binding|cytoplasm|cytosol|phosphatidic acid biosynthetic process|lipid catabolic process|metal ion binding|positive regulation of mitochondrial fission DDHD2 920.3906172 885.3922141 955.3890203 1.0790574 0.10977161 0.660492312 1 8.162334632 8.660243864 23259 DDHD domain containing 2 "GO:0004620,GO:0004806,GO:0005737,GO:0005793,GO:0005794,GO:0005829,GO:0006654,GO:0007626,GO:0008542,GO:0016020,GO:0019433,GO:0030134,GO:0034389,GO:0034451,GO:0046872,GO:0090141" phospholipase activity|triglyceride lipase activity|cytoplasm|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|phosphatidic acid biosynthetic process|locomotory behavior|visual learning|membrane|triglyceride catabolic process|COPII-coated ER to Golgi transport vesicle|lipid droplet organization|centriolar satellite|metal ion binding|positive regulation of mitochondrial fission DDI2 685.3294641 732.4513734 638.2075548 0.871330955 -0.198707297 0.441071824 1 3.664533947 3.139590967 84301 DNA damage inducible 1 homolog 2 "GO:0004190,GO:0005515,GO:0005654,GO:0005694,GO:0005829,GO:0010498,GO:0016485,GO:0031647,GO:0042802,GO:0043130,GO:0072711,GO:0097752" aspartic-type endopeptidase activity|protein binding|nucleoplasm|chromosome|cytosol|proteasomal protein catabolic process|protein processing|regulation of protein stability|identical protein binding|ubiquitin binding|cellular response to hydroxyurea|regulation of DNA stability DDIAS 627.7544559 697.0773014 558.4316104 0.801104281 -0.319938042 0.220032243 1 10.21184035 8.043855268 220042 DNA damage induced apoptosis suppressor "GO:0003674,GO:0005575,GO:0005634,GO:0005737,GO:0006915,GO:0071850,GO:0097752,GO:1902230" molecular_function|cellular_component|nucleus|cytoplasm|apoptotic process|mitotic cell cycle arrest|regulation of DNA stability|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage DDIT3 598.0429096 686.6731625 509.4126567 0.741856074 -0.430788775 0.101389046 1 40.35956457 29.43996625 1649 DNA damage inducible transcript 3 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001955,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005770,GO:0005829,GO:0006355,GO:0006357,GO:0006974,GO:0006983,GO:0006986,GO:0007050,GO:0007605,GO:0008134,GO:0008140,GO:0009948,GO:0010506,GO:0016055,GO:0030968,GO:0032088,GO:0032689,GO:0032700,GO:0032713,GO:0032757,GO:0032792,GO:0032993,GO:0034976,GO:0036488,GO:0036499,GO:0036500,GO:0042594,GO:0042803,GO:0043161,GO:0043433,GO:0043522,GO:0043525,GO:0043618,GO:0045454,GO:0045599,GO:0045662,GO:0045892,GO:0045893,GO:0045944,GO:0046982,GO:0051091,GO:0051209,GO:0051898,GO:0070059,GO:0072655,GO:0090090,GO:0120163,GO:0140416,GO:1902237,GO:1903026,GO:1990440,GO:1990442,GO:1990617,GO:1990622,GO:2000016,GO:2001244" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|blood vessel maturation|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|late endosome|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|ER overload response|response to unfolded protein|cell cycle arrest|sensory perception of sound|transcription factor binding|cAMP response element binding protein binding|anterior/posterior axis specification|regulation of autophagy|Wnt signaling pathway|endoplasmic reticulum unfolded protein response|negative regulation of NF-kappaB transcription factor activity|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-4 production|positive regulation of interleukin-8 production|negative regulation of CREB transcription factor activity|protein-DNA complex|response to endoplasmic reticulum stress|CHOP-C/EBP complex|PERK-mediated unfolded protein response|ATF6-mediated unfolded protein response|response to starvation|protein homodimerization activity|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of DNA-binding transcription factor activity|leucine zipper domain binding|positive regulation of neuron apoptotic process|regulation of transcription from RNA polymerase II promoter in response to stress|cell redox homeostasis|negative regulation of fat cell differentiation|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|positive regulation of DNA-binding transcription factor activity|release of sequestered calcium ion into cytosol|negative regulation of protein kinase B signaling|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|establishment of protein localization to mitochondrion|negative regulation of canonical Wnt signaling pathway|negative regulation of cold-induced thermogenesis|transcription regulator inhibitor activity|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|intrinsic apoptotic signaling pathway in response to nitrosative stress|CHOP-ATF4 complex|CHOP-ATF3 complex|negative regulation of determination of dorsal identity|positive regulation of intrinsic apoptotic signaling pathway" "hsa04010,hsa04141,hsa04210,hsa04932,hsa05010,hsa05012,hsa05014,hsa05020,hsa05022,hsa05202" MAPK signaling pathway|Protein processing in endoplasmic reticulum|Apoptosis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Transcriptional misregulation in cancer DDIT4 3611.506296 3670.580178 3552.432413 0.967812237 -0.047200914 0.843461639 1 112.3234621 106.8889396 54541 DNA damage inducible transcript 4 "GO:0001666,GO:0001764,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0006915,GO:0007420,GO:0010801,GO:0030182,GO:0032006,GO:0032007,GO:0032984,GO:0033137,GO:0042771,GO:0045820,GO:0048011,GO:0051607,GO:0071549,GO:0071889,GO:0072593,GO:1901216,GO:1902532" response to hypoxia|neuron migration|protein binding|cytoplasm|mitochondrion|cytosol|apoptotic process|brain development|negative regulation of peptidyl-threonine phosphorylation|neuron differentiation|regulation of TOR signaling|negative regulation of TOR signaling|protein-containing complex disassembly|negative regulation of peptidyl-serine phosphorylation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of glycolytic process|neurotrophin TRK receptor signaling pathway|defense response to virus|cellular response to dexamethasone stimulus|14-3-3 protein binding|reactive oxygen species metabolic process|positive regulation of neuron death|negative regulation of intracellular signal transduction "hsa04140,hsa04150,hsa04151,hsa05206" Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|MicroRNAs in cancer DDIT4L 215.838034 152.9408407 278.7352272 1.822503563 0.865921635 0.014505374 0.708244576 3.134474492 5.616998458 115265 DNA damage inducible transcript 4 like "GO:0005515,GO:0005737,GO:0009968" protein binding|cytoplasm|negative regulation of signal transduction DDN 22.89916625 20.80827765 24.99005486 1.200967003 0.264196513 0.788558325 1 0.242679094 0.28657257 23109 dendrin "GO:0005515,GO:0005634,GO:0005737,GO:0005789,GO:0032591,GO:0042995,GO:0043204,GO:0045211" protein binding|nucleus|cytoplasm|endoplasmic reticulum membrane|dendritic spine membrane|cell projection|perikaryon|postsynaptic membrane DDO 17.37503472 14.56579436 20.18427508 1.385731158 0.470647391 0.640298426 1 0.246386584 0.335712272 8528 D-aspartate oxidase "GO:0003884,GO:0005515,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0006533,GO:0006625,GO:0007320,GO:0007625,GO:0008445,GO:0019478,GO:0034641,GO:0042445,GO:0055114,GO:0071949" D-amino-acid oxidase activity|protein binding|cytoplasm|peroxisome|peroxisomal matrix|cytosol|aspartate catabolic process|protein targeting to peroxisome|insemination|grooming behavior|D-aspartate oxidase activity|D-amino acid catabolic process|cellular nitrogen compound metabolic process|hormone metabolic process|oxidation-reduction process|FAD binding "hsa00250,hsa04146" "Alanine, aspartate and glutamate metabolism|Peroxisome" DDOST 3883.269398 3878.662954 3887.875842 1.002375274 0.003422733 0.989756609 1 106.6445715 105.1090903 1650 dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit "GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0006486,GO:0006487,GO:0008047,GO:0008250,GO:0016020,GO:0016021,GO:0018279,GO:0031647,GO:0034097,GO:0035577,GO:0042110,GO:0043231,GO:0043312,GO:0050790" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|protein glycosylation|protein N-linked glycosylation|enzyme activator activity|oligosaccharyltransferase complex|membrane|integral component of membrane|protein N-linked glycosylation via asparagine|regulation of protein stability|response to cytokine|azurophil granule membrane|T cell activation|intracellular membrane-bounded organelle|neutrophil degranulation|regulation of catalytic activity "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum DDR1 891.084807 961.3424276 820.8271864 0.85383435 -0.227971892 0.359812712 1 10.6397923 8.932601327 780 discoidin domain receptor tyrosine kinase 1 "GO:0001558,GO:0001952,GO:0004714,GO:0005515,GO:0005518,GO:0005524,GO:0005615,GO:0005886,GO:0005887,GO:0007155,GO:0007169,GO:0007275,GO:0007566,GO:0007595,GO:0008285,GO:0010715,GO:0014909,GO:0030198,GO:0033674,GO:0038062,GO:0038063,GO:0038083,GO:0043235,GO:0043583,GO:0044319,GO:0046777,GO:0046872,GO:0060444,GO:0060749,GO:0061302,GO:0061564,GO:0070062,GO:1990138" "regulation of cell growth|regulation of cell-matrix adhesion|transmembrane receptor protein tyrosine kinase activity|protein binding|collagen binding|ATP binding|extracellular space|plasma membrane|integral component of plasma membrane|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|embryo implantation|lactation|negative regulation of cell population proliferation|regulation of extracellular matrix disassembly|smooth muscle cell migration|extracellular matrix organization|positive regulation of kinase activity|protein tyrosine kinase collagen receptor activity|collagen-activated tyrosine kinase receptor signaling pathway|peptidyl-tyrosine autophosphorylation|receptor complex|ear development|wound healing, spreading of cells|protein autophosphorylation|metal ion binding|branching involved in mammary gland duct morphogenesis|mammary gland alveolus development|smooth muscle cell-matrix adhesion|axon development|extracellular exosome|neuron projection extension" DDR2 53.23974554 60.34400519 46.13548589 0.764541328 -0.387333604 0.521509481 1 0.261654911 0.196698495 4921 discoidin domain receptor tyrosine kinase 2 "GO:0001503,GO:0003416,GO:0004714,GO:0005515,GO:0005518,GO:0005524,GO:0005886,GO:0005887,GO:0005925,GO:0007155,GO:0007165,GO:0007169,GO:0007275,GO:0010715,GO:0010763,GO:0015629,GO:0016324,GO:0018108,GO:0030198,GO:0030199,GO:0030500,GO:0031214,GO:0033674,GO:0034103,GO:0035988,GO:0038062,GO:0038063,GO:0043235,GO:0045669,GO:0045860,GO:0046777,GO:0048146,GO:0051091,GO:0090091" ossification|endochondral bone growth|transmembrane receptor protein tyrosine kinase activity|protein binding|collagen binding|ATP binding|plasma membrane|integral component of plasma membrane|focal adhesion|cell adhesion|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|regulation of extracellular matrix disassembly|positive regulation of fibroblast migration|actin cytoskeleton|apical plasma membrane|peptidyl-tyrosine phosphorylation|extracellular matrix organization|collagen fibril organization|regulation of bone mineralization|biomineral tissue development|positive regulation of kinase activity|regulation of tissue remodeling|chondrocyte proliferation|protein tyrosine kinase collagen receptor activity|collagen-activated tyrosine kinase receptor signaling pathway|receptor complex|positive regulation of osteoblast differentiation|positive regulation of protein kinase activity|protein autophosphorylation|positive regulation of fibroblast proliferation|positive regulation of DNA-binding transcription factor activity|positive regulation of extracellular matrix disassembly DDRGK1 723.7316573 642.9757795 804.4875352 1.251194152 0.323305675 0.205033408 1 26.33494675 32.39875554 65992 DDRGK domain containing 1 "GO:0001103,GO:0005515,GO:0005730,GO:0005737,GO:0005783,GO:0005789,GO:0008284,GO:0010628,GO:0010629,GO:0030335,GO:0031647,GO:0032435,GO:0032436,GO:0033146,GO:0034976,GO:0043066,GO:0044389,GO:0045944,GO:0051092,GO:0051216,GO:0061709,GO:0070972,GO:0071569,GO:1901800,GO:1902808,GO:1903721,GO:1903895,GO:1905050,GO:1905552,GO:1905636,GO:1990592" RNA polymerase II repressing transcription factor binding|protein binding|nucleolus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|positive regulation of cell population proliferation|positive regulation of gene expression|negative regulation of gene expression|positive regulation of cell migration|regulation of protein stability|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of intracellular estrogen receptor signaling pathway|response to endoplasmic reticulum stress|negative regulation of apoptotic process|ubiquitin-like protein ligase binding|positive regulation of transcription by RNA polymerase II|positive regulation of NF-kappaB transcription factor activity|cartilage development|reticulophagy|protein localization to endoplasmic reticulum|protein ufmylation|positive regulation of proteasomal protein catabolic process|positive regulation of cell cycle G1/S phase transition|positive regulation of I-kappaB phosphorylation|negative regulation of IRE1-mediated unfolded protein response|positive regulation of metallopeptidase activity|positive regulation of protein localization to endoplasmic reticulum|positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding|protein K69-linked ufmylation DDT 529.9800886 539.9748051 519.9853722 0.962980804 -0.054421054 0.846622235 1 31.49449499 29.82108617 1652 D-dopachrome tautomerase "GO:0004167,GO:0005126,GO:0005615,GO:0005737,GO:0010760,GO:0032760,GO:0033981,GO:0042438,GO:0050178,GO:0050729,GO:0070062,GO:0070374" dopachrome isomerase activity|cytokine receptor binding|extracellular space|cytoplasm|negative regulation of macrophage chemotaxis|positive regulation of tumor necrosis factor production|D-dopachrome decarboxylase activity|melanin biosynthetic process|phenylpyruvate tautomerase activity|positive regulation of inflammatory response|extracellular exosome|positive regulation of ERK1 and ERK2 cascade DDTL 44.31696961 40.57614142 48.0577978 1.184385605 0.244138861 0.723513712 1 0.521549637 0.607379243 100037417 D-dopachrome tautomerase like "GO:0005737,GO:0016829,GO:0070062" cytoplasm|lyase activity|extracellular exosome DDX1 2562.357222 2495.952904 2628.76154 1.053209592 0.074792565 0.752901715 1 53.62496745 55.53324171 1653 DEAD-box helicase 1 "GO:0000245,GO:0003677,GO:0003682,GO:0003712,GO:0003723,GO:0003724,GO:0004386,GO:0004518,GO:0004527,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006302,GO:0006355,GO:0006388,GO:0006446,GO:0007275,GO:0008143,GO:0010494,GO:0016020,GO:0016032,GO:0032508,GO:0033677,GO:0043123,GO:0045087,GO:0051607,GO:0071920,GO:0072669,GO:0090305,GO:1903608,GO:1990904" "spliceosomal complex assembly|DNA binding|chromatin binding|transcription coregulator activity|RNA binding|RNA helicase activity|helicase activity|nuclease activity|exonuclease activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|double-strand break repair|regulation of transcription, DNA-templated|tRNA splicing, via endonucleolytic cleavage and ligation|regulation of translational initiation|multicellular organism development|poly(A) binding|cytoplasmic stress granule|membrane|viral process|DNA duplex unwinding|DNA/RNA helicase activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|defense response to virus|cleavage body|tRNA-splicing ligase complex|nucleic acid phosphodiester bond hydrolysis|protein localization to cytoplasmic stress granule|ribonucleoprotein complex" DDX10 1002.603436 999.8377412 1005.36913 1.005532286 0.007959406 0.978733782 1 16.58672758 16.39939816 1662 DEAD-box helicase 10 "GO:0003723,GO:0003724,GO:0005524,GO:0005634,GO:0006364,GO:0097065" RNA binding|RNA helicase activity|ATP binding|nucleus|rRNA processing|anterior head development DDX11 853.8230216 904.119664 803.5263792 0.88873897 -0.170168345 0.497275886 1 6.705281374 5.859524971 1663 DEAD/H-box helicase 11 "GO:0000785,GO:0000922,GO:0001650,GO:0003677,GO:0003678,GO:0003682,GO:0003688,GO:0003690,GO:0003697,GO:0003727,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0006281,GO:0006974,GO:0007062,GO:0007275,GO:0008094,GO:0008186,GO:0016032,GO:0030496,GO:0030892,GO:0031297,GO:0031390,GO:0032079,GO:0032091,GO:0032508,GO:0034085,GO:0035563,GO:0036498,GO:0044806,GO:0045142,GO:0045876,GO:0046872,GO:0051539,GO:0051880,GO:0070062,GO:0072711,GO:0072719,GO:1901838,GO:1904976,GO:1990700,GO:2000781" "chromatin|spindle pole|fibrillar center|DNA binding|DNA helicase activity|chromatin binding|DNA replication origin binding|double-stranded DNA binding|single-stranded DNA binding|single-stranded RNA binding|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|DNA repair|cellular response to DNA damage stimulus|sister chromatid cohesion|multicellular organism development|DNA-dependent ATPase activity|RNA-dependent ATPase activity|viral process|midbody|mitotic cohesin complex|replication fork processing|Ctf18 RFC-like complex|positive regulation of endodeoxyribonuclease activity|negative regulation of protein binding|DNA duplex unwinding|establishment of sister chromatid cohesion|positive regulation of chromatin binding|IRE1-mediated unfolded protein response|G-quadruplex DNA unwinding|triplex DNA binding|positive regulation of sister chromatid cohesion|metal ion binding|4 iron, 4 sulfur cluster binding|G-quadruplex DNA binding|extracellular exosome|cellular response to hydroxyurea|cellular response to cisplatin|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|cellular response to bleomycin|nucleolar chromatin organization|positive regulation of double-strand break repair" DDX17 10147.2476 10228.30888 10066.18633 0.984149623 -0.023050426 0.927386718 1 114.5093447 110.8085414 10521 DEAD-box helicase 17 "GO:0000380,GO:0000381,GO:0001837,GO:0003713,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006357,GO:0006364,GO:0006396,GO:0008186,GO:0010586,GO:0016020,GO:0016607,GO:0030520,GO:0030521,GO:0031047,GO:0045445,GO:0045944,GO:0051607,GO:1990904,GO:2001014" "alternative mRNA splicing, via spliceosome|regulation of alternative mRNA splicing, via spliceosome|epithelial to mesenchymal transition|transcription coactivator activity|RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|rRNA processing|RNA processing|RNA-dependent ATPase activity|miRNA metabolic process|membrane|nuclear speck|intracellular estrogen receptor signaling pathway|androgen receptor signaling pathway|gene silencing by RNA|myoblast differentiation|positive regulation of transcription by RNA polymerase II|defense response to virus|ribonucleoprotein complex|regulation of skeletal muscle cell differentiation" DDX18 1904.320709 1912.280716 1896.360701 0.991674855 -0.01206092 0.961796834 1 27.19288761 26.51525496 8886 DEAD-box helicase 18 "GO:0000463,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005694,GO:0005730,GO:0016020,GO:0071392" "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|RNA helicase activity|protein binding|ATP binding|chromosome|nucleolus|membrane|cellular response to estradiol stimulus" DDX19A 1036.209296 986.3123607 1086.10623 1.101178768 0.139048698 0.572314325 1 16.78497383 18.17396453 55308 DEAD-box helicase 19A "GO:0003674,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0008150,GO:0010494,GO:0016020,GO:0016973" molecular_function|RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|biological_process|cytoplasmic stress granule|membrane|poly(A)+ mRNA export from nucleus "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway DDX19B 673.879881 722.0472346 625.7125274 0.866581156 -0.206593229 0.424241988 1 10.16468843 8.661128675 11269 DEAD-box helicase 19B "GO:0003723,GO:0003724,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005643,GO:0005654,GO:0005737,GO:0006406,GO:0010494,GO:0016020,GO:0016973,GO:0070062" RNA binding|RNA helicase activity|helicase activity|protein binding|ATP binding|nucleus|nuclear pore|nucleoplasm|cytoplasm|mRNA export from nucleus|cytoplasmic stress granule|membrane|poly(A)+ mRNA export from nucleus|extracellular exosome "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway DDX20 563.7142819 605.5208797 521.9076841 0.861915256 -0.214382065 0.422398198 1 8.976537903 7.607546498 11218 DEAD-box helicase 20 "GO:0000122,GO:0000244,GO:0000387,GO:0003677,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006396,GO:0016020,GO:0032797,GO:0034719,GO:0043065,GO:0051170,GO:0070491,GO:0097504" negative regulation of transcription by RNA polymerase II|spliceosomal tri-snRNP complex assembly|spliceosomal snRNP assembly|DNA binding|RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|RNA processing|membrane|SMN complex|SMN-Sm protein complex|positive regulation of apoptotic process|import into nucleus|repressing transcription factor binding|Gemini of coiled bodies hsa03013 RNA transport DDX21 7149.366004 8031.995174 6266.736833 0.780221688 -0.358043993 0.143715503 1 89.20974407 68.43865885 9188 DExD-box helicase 21 "GO:0001649,GO:0002735,GO:0003723,GO:0003724,GO:0003725,GO:0005515,GO:0005524,GO:0005654,GO:0005694,GO:0005730,GO:0005739,GO:0005829,GO:0006364,GO:0006366,GO:0016020,GO:0019843,GO:0030515,GO:0035198,GO:0042802,GO:0043123,GO:0043330,GO:0045087,GO:0045815,GO:0051607,GO:0062176,GO:0097322" "osteoblast differentiation|positive regulation of myeloid dendritic cell cytokine production|RNA binding|RNA helicase activity|double-stranded RNA binding|protein binding|ATP binding|nucleoplasm|chromosome|nucleolus|mitochondrion|cytosol|rRNA processing|transcription by RNA polymerase II|membrane|rRNA binding|snoRNA binding|miRNA binding|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to exogenous dsRNA|innate immune response|positive regulation of gene expression, epigenetic|defense response to virus|R-loop disassembly|7SK snRNA binding" DDX23 2093.241346 2077.706524 2108.776167 1.014953817 0.021414083 0.929956665 1 34.05509168 33.98595779 9416 DEAD-box helicase 23 "GO:0000354,GO:0000375,GO:0000398,GO:0000785,GO:0003723,GO:0003724,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005682,GO:0005730,GO:0008380,GO:0046540,GO:0062176,GO:0070062,GO:0071013" "cis assembly of pre-catalytic spliceosome|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|chromatin|RNA binding|RNA helicase activity|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|U5 snRNP|nucleolus|RNA splicing|U4/U6 x U5 tri-snRNP complex|R-loop disassembly|extracellular exosome|catalytic step 2 spliceosome" hsa03040 Spliceosome DDX24 4376.94567 4071.139523 4682.751818 1.150231229 0.201923913 0.397949942 1 38.98604592 44.09258119 57062 DEAD-box helicase 24 "GO:0003723,GO:0003724,GO:0005524,GO:0005730,GO:0016020,GO:0016070" RNA binding|RNA helicase activity|ATP binding|nucleolus|membrane|RNA metabolic process DDX27 1734.097339 1859.219608 1608.97507 0.865403454 -0.208555216 0.379870931 1 37.2599074 31.70527861 55661 DEAD-box helicase 27 "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005694,GO:0005730,GO:0006364" RNA binding|RNA helicase activity|protein binding|ATP binding|chromosome|nucleolus|rRNA processing DDX28 194.4642756 222.6485709 166.2799804 0.746827072 -0.421153869 0.252522818 1 5.128331902 3.765887621 55794 DEAD-box helicase 28 "GO:0003723,GO:0003724,GO:0005524,GO:0005654,GO:0005730,GO:0005739,GO:0005829,GO:0019843,GO:0035770,GO:0042645,GO:1902775" RNA binding|RNA helicase activity|ATP binding|nucleoplasm|nucleolus|mitochondrion|cytosol|rRNA binding|ribonucleoprotein granule|mitochondrial nucleoid|mitochondrial large ribosomal subunit assembly DDX31 448.1384078 498.3582498 397.9185658 0.798458872 -0.324709998 0.247713576 1 3.793533568 2.978294645 64794 DEAD-box helicase 31 "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005730,GO:0005794,GO:0042254,GO:0043231" RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleolus|Golgi apparatus|ribosome biogenesis|intracellular membrane-bounded organelle DDX39A 957.0730594 889.5538697 1024.592249 1.151804611 0.203896003 0.40980819 1 27.05062968 30.63566914 10212 DExD-box helicase 39A "GO:0000398,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006405,GO:0006406,GO:0016020,GO:0016607,GO:0016887,GO:0031124,GO:0042802" "mRNA splicing, via spliceosome|RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|RNA export from nucleus|mRNA export from nucleus|membrane|nuclear speck|ATPase activity|mRNA 3'-end processing|identical protein binding" DDX39B 3637.726077 3500.992715 3774.459439 1.078111195 0.108505983 0.648403292 1 111.1490462 117.825821 7919 DExD-box helicase 39B "GO:0000245,GO:0000346,GO:0000398,GO:0001889,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005681,GO:0005687,GO:0005688,GO:0005737,GO:0006405,GO:0006406,GO:0008186,GO:0008380,GO:0010501,GO:0016363,GO:0016607,GO:0016887,GO:0017070,GO:0030621,GO:0031124,GO:0032786,GO:0042802,GO:0043008,GO:0044877,GO:0045727,GO:0046784,GO:0061051,GO:1904707,GO:2000002,GO:2000573" "spliceosomal complex assembly|transcription export complex|mRNA splicing, via spliceosome|liver development|RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|spliceosomal complex|U4 snRNP|U6 snRNP|cytoplasm|RNA export from nucleus|mRNA export from nucleus|RNA-dependent ATPase activity|RNA splicing|RNA secondary structure unwinding|nuclear matrix|nuclear speck|ATPase activity|U6 snRNA binding|U4 snRNA binding|mRNA 3'-end processing|positive regulation of DNA-templated transcription, elongation|identical protein binding|ATP-dependent protein binding|protein-containing complex binding|positive regulation of translation|viral mRNA export from host cell nucleus|positive regulation of cell growth involved in cardiac muscle cell development|positive regulation of vascular associated smooth muscle cell proliferation|negative regulation of DNA damage checkpoint|positive regulation of DNA biosynthetic process" "hsa03013,hsa03015,hsa03040" RNA transport|mRNA surveillance pathway|Spliceosome DDX3X 7037.836584 7324.513734 6751.159435 0.921721179 -0.117597694 0.630719389 1 57.09008852 51.74060013 1654 DEAD-box helicase 3 X-linked "GO:0003677,GO:0003678,GO:0003723,GO:0003724,GO:0003729,GO:0003924,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005852,GO:0005886,GO:0006413,GO:0007059,GO:0007276,GO:0008134,GO:0008143,GO:0008190,GO:0008625,GO:0009615,GO:0010494,GO:0010501,GO:0010628,GO:0016032,GO:0016055,GO:0016887,GO:0017111,GO:0017148,GO:0022627,GO:0030027,GO:0030154,GO:0030307,GO:0030308,GO:0031252,GO:0031333,GO:0031369,GO:0031954,GO:0032508,GO:0032727,GO:0032728,GO:0033592,GO:0034063,GO:0034157,GO:0034161,GO:0034774,GO:0035556,GO:0035613,GO:0036493,GO:0042256,GO:0043015,GO:0043024,GO:0043065,GO:0043066,GO:0043154,GO:0043186,GO:0043273,GO:0043280,GO:0043312,GO:0043539,GO:0045070,GO:0045087,GO:0045296,GO:0045727,GO:0045944,GO:0045948,GO:0048027,GO:0055088,GO:0070062,GO:0071243,GO:0071470,GO:0071651,GO:0071902,GO:0072559,GO:0090263,GO:0097193,GO:0098586,GO:1900087,GO:1900227,GO:1901223,GO:1901224,GO:1901985,GO:1902042,GO:1902523,GO:1903608,GO:1904813,GO:2001243" DNA binding|DNA helicase activity|RNA binding|RNA helicase activity|mRNA binding|GTPase activity|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|eukaryotic translation initiation factor 3 complex|plasma membrane|translational initiation|chromosome segregation|gamete generation|transcription factor binding|poly(A) binding|eukaryotic initiation factor 4E binding|extrinsic apoptotic signaling pathway via death domain receptors|response to virus|cytoplasmic stress granule|RNA secondary structure unwinding|positive regulation of gene expression|viral process|Wnt signaling pathway|ATPase activity|nucleoside-triphosphatase activity|negative regulation of translation|cytosolic small ribosomal subunit|lamellipodium|cell differentiation|positive regulation of cell growth|negative regulation of cell growth|cell leading edge|negative regulation of protein-containing complex assembly|translation initiation factor binding|positive regulation of protein autophosphorylation|DNA duplex unwinding|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|RNA strand annealing activity|stress granule assembly|positive regulation of toll-like receptor 7 signaling pathway|positive regulation of toll-like receptor 8 signaling pathway|secretory granule lumen|intracellular signal transduction|RNA stem-loop binding|positive regulation of translation in response to endoplasmic reticulum stress|mature ribosome assembly|gamma-tubulin binding|ribosomal small subunit binding|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|P granule|CTPase activity|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|neutrophil degranulation|protein serine/threonine kinase activator activity|positive regulation of viral genome replication|innate immune response|cadherin binding|positive regulation of translation|positive regulation of transcription by RNA polymerase II|positive regulation of translational initiation|mRNA 5'-UTR binding|lipid homeostasis|extracellular exosome|cellular response to arsenic-containing substance|cellular response to osmotic stress|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of protein serine/threonine kinase activity|NLRP3 inflammasome complex|positive regulation of canonical Wnt signaling pathway|intrinsic apoptotic signaling pathway|cellular response to virus|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of NLRP3 inflammasome complex assembly|negative regulation of NIK/NF-kappaB signaling|positive regulation of NIK/NF-kappaB signaling|positive regulation of protein acetylation|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of protein K63-linked ubiquitination|protein localization to cytoplasmic stress granule|ficolin-1-rich granule lumen|negative regulation of intrinsic apoptotic signaling pathway "hsa04622,hsa05161,hsa05203" RIG-I-like receptor signaling pathway|Hepatitis B|Viral carcinogenesis DDX41 1234.106814 1236.011693 1232.201936 0.996917701 -0.004453684 0.989100871 1 28.85549971 28.28518905 51428 DEAD-box helicase 41 "GO:0000398,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005681,GO:0005829,GO:0006915,GO:0008283,GO:0016020,GO:0030154,GO:0032481,GO:0046872,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|spliceosomal complex|cytosol|apoptotic process|cell population proliferation|membrane|cell differentiation|positive regulation of type I interferon production|metal ion binding|catalytic step 2 spliceosome" DDX42 4074.175899 4184.544636 3963.807163 0.947249344 -0.078183859 0.743466913 1 45.142805 42.04593677 11325 DEAD-box helicase 42 "GO:0000398,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008104,GO:0015030,GO:0016020,GO:0016607,GO:0042981" "mRNA splicing, via spliceosome|RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein localization|Cajal body|membrane|nuclear speck|regulation of apoptotic process" hsa03040 Spliceosome DDX46 1377.932379 1403.518328 1352.34643 0.963540271 -0.05358313 0.82578972 1 12.3378675 11.68910208 9879 DEAD-box helicase 46 "GO:0000398,GO:0001650,GO:0003723,GO:0003724,GO:0005524,GO:0005634,GO:0005654,GO:0015030,GO:0016020,GO:0016607" "mRNA splicing, via spliceosome|fibrillar center|RNA binding|RNA helicase activity|ATP binding|nucleus|nucleoplasm|Cajal body|membrane|nuclear speck" hsa03040 Spliceosome DDX47 1587.206482 1447.215711 1727.197253 1.193462205 0.255152879 0.284011757 1 42.507013 49.88160701 51202 DEAD-box helicase 47 "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0006397,GO:0008380,GO:0008625,GO:0016020" RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|rRNA processing|mRNA processing|RNA splicing|extrinsic apoptotic signaling pathway via death domain receptors|membrane DDX49 250.3050559 288.1946455 212.4154663 0.737055562 -0.440154717 0.188801369 1 8.176724376 5.925851511 54555 DEAD-box helicase 49 "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006364,GO:0030307,GO:0044357" RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|rRNA processing|positive regulation of cell growth|regulation of rRNA stability DDX5 12263.44971 11975.16379 12551.73563 1.048147303 0.067841483 0.791557298 1 155.3835356 160.1395114 1655 DEAD-box helicase 5 "GO:0000122,GO:0000380,GO:0000381,GO:0000398,GO:0000956,GO:0001837,GO:0003723,GO:0003724,GO:0003730,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006357,GO:0009299,GO:0016020,GO:0030509,GO:0030520,GO:0030521,GO:0035500,GO:0036002,GO:0043021,GO:0043517,GO:0045445,GO:0045667,GO:0046332,GO:0048511,GO:0050681,GO:0060765,GO:0061614,GO:0070062,GO:0070412,GO:0070878,GO:0071013,GO:0072332,GO:1902893,GO:1903800,GO:1990841,GO:1990904,GO:2001014" "negative regulation of transcription by RNA polymerase II|alternative mRNA splicing, via spliceosome|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process|epithelial to mesenchymal transition|RNA binding|RNA helicase activity|mRNA 3'-UTR binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|regulation of transcription by RNA polymerase II|mRNA transcription|membrane|BMP signaling pathway|intracellular estrogen receptor signaling pathway|androgen receptor signaling pathway|MH2 domain binding|pre-mRNA binding|ribonucleoprotein complex binding|positive regulation of DNA damage response, signal transduction by p53 class mediator|myoblast differentiation|regulation of osteoblast differentiation|SMAD binding|rhythmic process|androgen receptor binding|regulation of androgen receptor signaling pathway|pri-miRNA transcription by RNA polymerase II|extracellular exosome|R-SMAD binding|primary miRNA binding|catalytic step 2 spliceosome|intrinsic apoptotic signaling pathway by p53 class mediator|regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of production of miRNAs involved in gene silencing by miRNA|promoter-specific chromatin binding|ribonucleoprotein complex|regulation of skeletal muscle cell differentiation" "hsa03040,hsa05202,hsa05205" Spliceosome|Transcriptional misregulation in cancer|Proteoglycans in cancer other DDX50 2038.20885 1894.59368 2181.82402 1.151605245 0.203646265 0.389671814 1 16.11073655 18.2427459 79009 DExD-box helicase 50 "GO:0003723,GO:0003724,GO:0005524,GO:0005730,GO:0005886,GO:0016020" RNA binding|RNA helicase activity|ATP binding|nucleolus|plasma membrane|membrane DDX51 570.2888882 588.8742576 551.7035187 0.936878309 -0.094066426 0.728115082 1 6.638600934 6.115485284 317781 DEAD-box helicase 51 "GO:0003723,GO:0003724,GO:0005524,GO:0005634,GO:0005730,GO:0006364,GO:0016020" RNA binding|RNA helicase activity|ATP binding|nucleus|nucleolus|rRNA processing|membrane DDX52 1221.670923 1288.032387 1155.309459 0.89695684 -0.156889528 0.517642731 1 10.29194807 9.076957685 11056 DExD-box helicase 52 "GO:0003723,GO:0003724,GO:0005524,GO:0005654,GO:0005730,GO:0006364,GO:0016020,GO:0030490" RNA binding|RNA helicase activity|ATP binding|nucleoplasm|nucleolus|rRNA processing|membrane|maturation of SSU-rRNA DDX54 1584.262649 1597.03531 1571.489988 0.984004535 -0.02326313 0.924897633 1 19.45909572 18.8274253 79039 DEAD-box helicase 54 "GO:0003714,GO:0003723,GO:0003724,GO:0005102,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005794,GO:0006364,GO:0006396,GO:0016020,GO:0016070,GO:0030331,GO:0030520,GO:0045892" "transcription corepressor activity|RNA binding|RNA helicase activity|signaling receptor binding|ATP binding|nucleus|nucleoplasm|nucleolus|Golgi apparatus|rRNA processing|RNA processing|membrane|RNA metabolic process|estrogen receptor binding|intracellular estrogen receptor signaling pathway|negative regulation of transcription, DNA-templated" DDX55 545.214545 599.2783964 491.1506935 0.819570164 -0.28706063 0.284858134 1 8.788784443 7.082492629 57696 DEAD-box helicase 55 "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005829,GO:0016020" RNA binding|RNA helicase activity|protein binding|ATP binding|nucleoplasm|nucleolus|cytosol|membrane DDX56 1453.318955 1363.9826 1542.655309 1.130993393 0.177590502 0.458310867 1 39.24164123 43.63936369 54606 DEAD-box helicase 56 "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005730,GO:0006364,GO:0010976,GO:0016020" RNA binding|RNA helicase activity|protein binding|ATP binding|nucleolus|rRNA processing|positive regulation of neuron projection development|membrane DDX58 1136.64825 1289.072801 984.2236989 0.76351289 -0.389275582 0.109329085 1 14.82341007 11.12847552 23586 DExD/H-box helicase 58 "GO:0002230,GO:0002735,GO:0003724,GO:0003725,GO:0003727,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005923,GO:0008270,GO:0009597,GO:0009615,GO:0010628,GO:0015629,GO:0016032,GO:0016579,GO:0030334,GO:0031625,GO:0032480,GO:0032587,GO:0032725,GO:0032727,GO:0032728,GO:0032755,GO:0032757,GO:0032760,GO:0034344,GO:0039528,GO:0039529,GO:0042802,GO:0043330,GO:0045087,GO:0045944,GO:0051091,GO:0051607,GO:0060760,GO:0071360,GO:0140374,GO:1990904" positive regulation of defense response to virus by host|positive regulation of myeloid dendritic cell cytokine production|RNA helicase activity|double-stranded RNA binding|single-stranded RNA binding|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|bicellular tight junction|zinc ion binding|detection of virus|response to virus|positive regulation of gene expression|actin cytoskeleton|viral process|protein deubiquitination|regulation of cell migration|ubiquitin protein ligase binding|negative regulation of type I interferon production|ruffle membrane|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|regulation of type III interferon production|cytoplasmic pattern recognition receptor signaling pathway in response to virus|RIG-I signaling pathway|identical protein binding|response to exogenous dsRNA|innate immune response|positive regulation of transcription by RNA polymerase II|positive regulation of DNA-binding transcription factor activity|defense response to virus|positive regulation of response to cytokine stimulus|cellular response to exogenous dsRNA|antiviral innate immune response|ribonucleoprotein complex "hsa04064,hsa04622,hsa04623,hsa05160,hsa05161,hsa05162,hsa05164,hsa05168,hsa05169,hsa05171" NF-kappa B signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 DDX59 405.9915847 439.0546585 372.9285109 0.849389714 -0.235501456 0.41577535 1 6.990316281 5.838146681 83479 DEAD-box helicase 59 "GO:0003723,GO:0003724,GO:0005524,GO:0005634,GO:0005737,GO:0046872" RNA binding|RNA helicase activity|ATP binding|nucleus|cytoplasm|metal ion binding DDX6 2825.695791 3038.008537 2613.383044 0.860228999 -0.217207328 0.358671504 1 25.57301767 21.63053376 1656 DEAD-box helicase 6 "GO:0000792,GO:0000932,GO:0001520,GO:0003723,GO:0003724,GO:0003729,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0005912,GO:0010494,GO:0016020,GO:0016442,GO:0017148,GO:0019074,GO:0019827,GO:0019904,GO:0033391,GO:0033962,GO:0034063,GO:0036464,GO:0043928,GO:0045296,GO:0045665,GO:0048471,GO:0048515,GO:0061830,GO:0097227,GO:1905618" heterochromatin|P-body|outer dense fiber|RNA binding|RNA helicase activity|mRNA binding|helicase activity|protein binding|ATP binding|nucleus|nucleolus|cytoplasm|mitochondrion|cytosol|adherens junction|cytoplasmic stress granule|membrane|RISC complex|negative regulation of translation|viral RNA genome packaging|stem cell population maintenance|protein domain specific binding|chromatoid body|P-body assembly|stress granule assembly|cytoplasmic ribonucleoprotein granule|exonucleolytic catabolism of deadenylated mRNA|cadherin binding|negative regulation of neuron differentiation|perinuclear region of cytoplasm|spermatid differentiation|concave side of sperm head|sperm annulus|positive regulation of miRNA mediated inhibition of translation hsa03018 RNA degradation DDX60 727.6543103 846.8969005 608.4117201 0.718401165 -0.477138405 0.060987919 1 4.470999213 3.158223059 55601 DExD/H-box helicase 60 "GO:0003690,GO:0003724,GO:0003725,GO:0003727,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0009615,GO:0045087,GO:0045111,GO:0051607,GO:1900245,GO:1900246" double-stranded DNA binding|RNA helicase activity|double-stranded RNA binding|single-stranded RNA binding|protein binding|ATP binding|cytoplasm|cytosol|response to virus|innate immune response|intermediate filament cytoskeleton|defense response to virus|positive regulation of MDA-5 signaling pathway|positive regulation of RIG-I signaling pathway DDX60L 1085.346522 1090.353749 1080.339295 0.990815408 -0.013311791 0.960638032 1 6.820226864 6.644506814 91351 DExD/H-box 60 like "GO:0003723,GO:0003724,GO:0005524" RNA binding|RNA helicase activity|ATP binding DEAF1 746.8975511 796.9570341 696.8380681 0.874373446 -0.193678507 0.447003229 1 11.56392935 9.941995639 10522 DEAF1 transcription factor "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0001650,GO:0001843,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006366,GO:0007281,GO:0009653,GO:0033599,GO:0045892,GO:0045893,GO:0046872,GO:0048706" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|fibrillar center|neural tube closure|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|germ cell development|anatomical structure morphogenesis|regulation of mammary gland epithelial cell proliferation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|embryonic skeletal system development" DECR1 1060.560871 881.2305586 1239.891183 1.406999759 0.492622081 0.04408934 1 25.79794585 35.69031067 1666 "2,4-dienoyl-CoA reductase 1" "GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0006635,GO:0008670,GO:0042802,GO:0070402,GO:0120162,GO:1902494" "nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|fatty acid beta-oxidation|2,4-dienoyl-CoA reductase (NADPH) activity|identical protein binding|NADPH binding|positive regulation of cold-induced thermogenesis|catalytic complex" DECR2 294.2357967 293.3967149 295.0748785 1.005719776 0.008228383 0.991557976 1 10.09545031 9.983294078 26063 "2,4-dienoyl-CoA reductase 2" "GO:0005515,GO:0005778,GO:0005829,GO:0006625,GO:0006636,GO:0008670,GO:0019166,GO:0033540" "protein binding|peroxisomal membrane|cytosol|protein targeting to peroxisome|unsaturated fatty acid biosynthetic process|2,4-dienoyl-CoA reductase (NADPH) activity|trans-2-enoyl-CoA reductase (NADPH) activity|fatty acid beta-oxidation using acyl-CoA oxidase" hsa04146 Peroxisome DEDD 1094.794535 1098.67706 1090.91201 0.992932364 -0.010232647 0.970690122 1 15.30524025 14.94276602 9191 death effector domain containing "GO:0003677,GO:0005515,GO:0005730,GO:0005737,GO:0007283,GO:0008625,GO:0042981" DNA binding|protein binding|nucleolus|cytoplasm|spermatogenesis|extrinsic apoptotic signaling pathway via death domain receptors|regulation of apoptotic process DEDD2 495.4136872 452.5800389 538.2473354 1.189286511 0.250096316 0.362743068 1 10.58893681 12.38254823 162989 death effector domain containing 2 "GO:0003677,GO:0005515,GO:0005654,GO:0005730,GO:0006396,GO:0008625,GO:0016075,GO:0019725,GO:0030159,GO:0030262,GO:0035556,GO:0045892,GO:2001238" "DNA binding|protein binding|nucleoplasm|nucleolus|RNA processing|extrinsic apoptotic signaling pathway via death domain receptors|rRNA catabolic process|cellular homeostasis|signaling receptor complex adaptor activity|apoptotic nuclear changes|intracellular signal transduction|negative regulation of transcription, DNA-templated|positive regulation of extrinsic apoptotic signaling pathway" DEF6 325.6715101 298.5987843 352.7442358 1.181331788 0.240414216 0.436481814 1 6.94062209 8.061975373 50619 DEF6 guanine nucleotide exchange factor "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0016020,GO:0030175,GO:0048471" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|plasma membrane|membrane|filopodium|perinuclear region of cytoplasm DEF8 987.0072882 943.6553916 1030.359185 1.09188078 0.12681534 0.608595522 1 11.27656827 12.10663233 54849 differentially expressed in FDCP 8 homolog "GO:0032418,GO:0035556,GO:0045780,GO:0046872,GO:1900029" lysosome localization|intracellular signal transduction|positive regulation of bone resorption|metal ion binding|positive regulation of ruffle assembly DEGS1 2657.431175 2695.71237 2619.14998 0.971598457 -0.041567896 0.861892161 1 60.01886303 57.33842498 8560 "delta 4-desaturase, sphingolipid 1" "GO:0005515,GO:0005739,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0006636,GO:0009055,GO:0016020,GO:0022900,GO:0030148,GO:0031966,GO:0035579,GO:0042284,GO:0043217,GO:0043312,GO:0046513,GO:0050251" protein binding|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|unsaturated fatty acid biosynthetic process|electron transfer activity|membrane|electron transport chain|sphingolipid biosynthetic process|mitochondrial membrane|specific granule membrane|sphingolipid delta-4 desaturase activity|myelin maintenance|neutrophil degranulation|ceramide biosynthetic process|retinol isomerase activity "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway DEGS2 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.04144686 0.025099165 123099 "delta 4-desaturase, sphingolipid 2" "GO:0000170,GO:0005789,GO:0006667,GO:0016021,GO:0030148,GO:0042284,GO:0046513,GO:0055114" sphingosine hydroxylase activity|endoplasmic reticulum membrane|sphinganine metabolic process|integral component of membrane|sphingolipid biosynthetic process|sphingolipid delta-4 desaturase activity|ceramide biosynthetic process|oxidation-reduction process "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway DEK 4482.027472 4281.303127 4682.751818 1.093767874 0.129306593 0.588847267 1 61.20687897 65.82586524 7913 DEK proto-oncogene "GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0006357,GO:0006366,GO:0007165,GO:0019079,GO:0042393,GO:0045815,GO:2000779" "DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|chromatin organization|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|signal transduction|viral genome replication|histone binding|positive regulation of gene expression, epigenetic|regulation of double-strand break repair" DELE1 1373.097031 1377.507981 1368.686081 0.993595755 -0.009269086 0.972538467 1 11.89756743 11.62355783 9812 DAP3 binding cell death enhancer 1 "GO:0005515,GO:0005739,GO:0005743,GO:0005829,GO:0008625,GO:0043281" protein binding|mitochondrion|mitochondrial inner membrane|cytosol|extrinsic apoptotic signaling pathway via death domain receptors|regulation of cysteine-type endopeptidase activity involved in apoptotic process DENND10 604.8508736 587.8338437 621.8679035 1.057897415 0.081199735 0.762207244 1 10.71069029 11.14120578 404636 DENN domain containing 10 "GO:0005085,GO:0005770,GO:0015031,GO:0031267,GO:0032509,GO:0050790,GO:2000641" guanyl-nucleotide exchange factor activity|late endosome|protein transport|small GTPase binding|endosome transport via multivesicular body sorting pathway|regulation of catalytic activity|regulation of early endosome to late endosome transport DENND11 1360.388767 1409.760811 1311.016724 0.929956851 -0.104764317 0.66420368 1 10.04088395 9.181336915 57189 DENN domain containing 11 "GO:0005085,GO:0005737,GO:0050790" guanyl-nucleotide exchange factor activity|cytoplasm|regulation of catalytic activity DENND1A 689.6603107 619.0462602 760.2743612 1.228138202 0.296472916 0.248727795 1 3.072957041 3.710862891 57706 DENN domain containing 1A "GO:0005085,GO:0005654,GO:0005829,GO:0006897,GO:0015031,GO:0017124,GO:0030136,GO:0030425,GO:0030665,GO:0031267,GO:0032266,GO:0032456,GO:0032483,GO:0042734,GO:0043025,GO:0043231,GO:0043547,GO:0048488,GO:1901981" guanyl-nucleotide exchange factor activity|nucleoplasm|cytosol|endocytosis|protein transport|SH3 domain binding|clathrin-coated vesicle|dendrite|clathrin-coated vesicle membrane|small GTPase binding|phosphatidylinositol-3-phosphate binding|endocytic recycling|regulation of Rab protein signal transduction|presynaptic membrane|neuronal cell body|intracellular membrane-bounded organelle|positive regulation of GTPase activity|synaptic vesicle endocytosis|phosphatidylinositol phosphate binding DENND1B 357.9740302 339.1749257 376.7731347 1.110851971 0.15166658 0.61672514 1 0.74377049 0.81239326 163486 DENN domain containing 1B "GO:0005085,GO:0005829,GO:0006897,GO:0015031,GO:0016607,GO:0030136,GO:0031267,GO:0032456,GO:0035745,GO:0043231,GO:0043547,GO:0050776,GO:0050852,GO:1901981" guanyl-nucleotide exchange factor activity|cytosol|endocytosis|protein transport|nuclear speck|clathrin-coated vesicle|small GTPase binding|endocytic recycling|T-helper 2 cell cytokine production|intracellular membrane-bounded organelle|positive regulation of GTPase activity|regulation of immune response|T cell receptor signaling pathway|phosphatidylinositol phosphate binding DENND1C 10.29028235 5.202069413 15.3784953 2.95622647 1.563756795 0.18216591 1 0.084926547 0.246860923 79958 DENN domain containing 1C "GO:0005085,GO:0005515,GO:0005654,GO:0005813,GO:0005829,GO:0006897,GO:0030136,GO:0032456,GO:0043231,GO:0050790,GO:1901981" guanyl-nucleotide exchange factor activity|protein binding|nucleoplasm|centrosome|cytosol|endocytosis|clathrin-coated vesicle|endocytic recycling|intracellular membrane-bounded organelle|regulation of catalytic activity|phosphatidylinositol phosphate binding DENND2A 719.5102512 683.5519209 755.4685814 1.105210238 0.144320832 0.574436869 1 7.041094326 7.651670156 27147 DENN domain containing 2A "GO:0005085,GO:0005829,GO:0015031,GO:0015629,GO:0042147,GO:0050790" "guanyl-nucleotide exchange factor activity|cytosol|protein transport|actin cytoskeleton|retrograde transport, endosome to Golgi|regulation of catalytic activity" DENND2B 610.1466778 663.7840571 556.5092985 0.83838907 -0.254308186 0.332844062 1 5.652614512 4.659787968 6764 DENN domain containing 2B "GO:0005085,GO:0005515,GO:0005886,GO:0005938,GO:0050790,GO:0055037,GO:0070374" guanyl-nucleotide exchange factor activity|protein binding|plasma membrane|cell cortex|regulation of catalytic activity|recycling endosome|positive regulation of ERK1 and ERK2 cascade DENND2C 129.1905734 111.3242854 147.0568613 1.320977365 0.401605746 0.351797715 1 0.961821679 1.249283822 163259 DENN domain containing 2C "GO:0005085,GO:0005654,GO:0050790" guanyl-nucleotide exchange factor activity|nucleoplasm|regulation of catalytic activity DENND3 2344.18611 2269.142678 2419.229541 1.066142541 0.092400337 0.696977321 1 13.93234862 14.60531017 22898 DENN domain containing 3 "GO:0005085,GO:0005829,GO:0008333,GO:0031410,GO:0032483,GO:0044257,GO:0050790" guanyl-nucleotide exchange factor activity|cytosol|endosome to lysosome transport|cytoplasmic vesicle|regulation of Rab protein signal transduction|cellular protein catabolic process|regulation of catalytic activity DENND4A 933.4744343 1014.403536 852.545333 0.840440025 -0.250783224 0.31119801 1 3.970141706 3.280831408 10260 DENN domain containing 4A "GO:0003677,GO:0005085,GO:0005515,GO:0005634,GO:0005829,GO:0006355,GO:0031410,GO:0032483,GO:0050790" "DNA binding|guanyl-nucleotide exchange factor activity|protein binding|nucleus|cytosol|regulation of transcription, DNA-templated|cytoplasmic vesicle|regulation of Rab protein signal transduction|regulation of catalytic activity" DENND4B 1004.376064 1172.546446 836.2056817 0.713153568 -0.487715319 0.047162164 1 10.68955394 7.495728041 9909 DENN domain containing 4B "GO:0005085,GO:0005654,GO:0005794,GO:0005829,GO:0031410,GO:0032483,GO:0050790" guanyl-nucleotide exchange factor activity|nucleoplasm|Golgi apparatus|cytosol|cytoplasmic vesicle|regulation of Rab protein signal transduction|regulation of catalytic activity DENND4C 1073.767991 1101.798302 1045.73768 0.94911898 -0.075339143 0.760745437 1 7.815118334 7.293355706 55667 DENN domain containing 4C "GO:0005085,GO:0005794,GO:0005829,GO:0005886,GO:0015031,GO:0030659,GO:0030904,GO:0031410,GO:0032483,GO:0032593,GO:0032869,GO:0043231,GO:0050790,GO:0072659" guanyl-nucleotide exchange factor activity|Golgi apparatus|cytosol|plasma membrane|protein transport|cytoplasmic vesicle membrane|retromer complex|cytoplasmic vesicle|regulation of Rab protein signal transduction|insulin-responsive compartment|cellular response to insulin stimulus|intracellular membrane-bounded organelle|regulation of catalytic activity|protein localization to plasma membrane DENND5A 4955.191878 5386.22267 4524.161085 0.839950622 -0.251623575 0.294392013 1 57.18177928 47.22615626 23258 DENN domain containing 5A "GO:0000139,GO:0005085,GO:0005515,GO:0005802,GO:0005829,GO:0010977,GO:0030904,GO:0042147,GO:0050790" "Golgi membrane|guanyl-nucleotide exchange factor activity|protein binding|trans-Golgi network|cytosol|negative regulation of neuron projection development|retromer complex|retrograde transport, endosome to Golgi|regulation of catalytic activity" DENND5B 853.5556797 871.8668337 835.2445258 0.957995526 -0.061909177 0.808259586 1 3.820191337 3.598485647 160518 DENN domain containing 5B "GO:0005085,GO:0005829,GO:0016021,GO:0050790" guanyl-nucleotide exchange factor activity|cytosol|integral component of membrane|regulation of catalytic activity DENND6A 434.2513362 474.4287305 394.073942 0.830628325 -0.267725025 0.345351226 1 5.183088922 4.233178438 201627 DENN domain containing 6A "GO:0005085,GO:0005737,GO:0005829,GO:0043231,GO:0050790,GO:0055037,GO:2000049" guanyl-nucleotide exchange factor activity|cytoplasm|cytosol|intracellular membrane-bounded organelle|regulation of catalytic activity|recycling endosome|positive regulation of cell-cell adhesion mediated by cadherin DENND6B 146.3177735 144.6175297 148.0180172 1.023513661 0.033530358 0.952970073 1 1.591990875 1.602158198 414918 DENN domain containing 6B "GO:0005085,GO:0005829,GO:0050790,GO:0055037" guanyl-nucleotide exchange factor activity|cytosol|regulation of catalytic activity|recycling endosome DENR 2077.26903 1961.180169 2193.357892 1.118386738 0.161419158 0.495548654 1 38.49377753 42.33053127 8562 density regulated re-initiation and release factor "GO:0001731,GO:0002188,GO:0003674,GO:0003729,GO:0003743,GO:0005515,GO:0005575,GO:0032790,GO:0075522" formation of translation preinitiation complex|translation reinitiation|molecular_function|mRNA binding|translation initiation factor activity|protein binding|cellular_component|ribosome disassembly|IRES-dependent viral translational initiation DEPDC1 2033.374846 2461.619246 1605.130447 0.652062844 -0.616917081 0.009247778 0.589887864 24.79186543 15.8953406 55635 DEP domain containing 1 "GO:0005096,GO:0005515,GO:0005634,GO:0017053,GO:0035556,GO:0043547,GO:0045892" "GTPase activator activity|protein binding|nucleus|transcription repressor complex|intracellular signal transduction|positive regulation of GTPase activity|negative regulation of transcription, DNA-templated" DEPDC1B 860.2045135 869.7860059 850.6230211 0.977968161 -0.032140597 0.902214269 1 8.101026271 7.789972695 55789 DEP domain containing 1B "GO:0005096,GO:0005829,GO:0016477,GO:0030177,GO:0035556,GO:0043547,GO:0051056" GTPase activator activity|cytosol|cell migration|positive regulation of Wnt signaling pathway|intracellular signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction DEPDC4 64.77361701 60.34400519 69.20322883 1.146811993 0.197628896 0.738981841 1 0.40080257 0.451953654 120863 DEP domain containing 4 GO:0035556 intracellular signal transduction DEPDC5 370.4684433 440.0950724 300.8418142 0.683583692 -0.548810116 0.063003538 1 3.676172351 2.470920293 9681 "DEP domain containing 5, GATOR1 subcomplex subunit" "GO:0005096,GO:0005764,GO:0005765,GO:0005829,GO:0010506,GO:0031463,GO:0032007,GO:0034198,GO:0035556,GO:0043547,GO:0044877,GO:0048471,GO:1904262,GO:1990130" GTPase activator activity|lysosome|lysosomal membrane|cytosol|regulation of autophagy|Cul3-RING ubiquitin ligase complex|negative regulation of TOR signaling|cellular response to amino acid starvation|intracellular signal transduction|positive regulation of GTPase activity|protein-containing complex binding|perinuclear region of cytoplasm|negative regulation of TORC1 signaling|GATOR1 complex hsa04150 mTOR signaling pathway DEPDC7 86.75125627 82.19269673 91.30981582 1.110923713 0.15175975 0.777113553 1 1.984829484 2.168096549 91614 DEP domain containing 7 "GO:0003674,GO:0005575,GO:0005829,GO:0008150,GO:0035556,GO:0051056" molecular_function|cellular_component|cytosol|biological_process|intracellular signal transduction|regulation of small GTPase mediated signal transduction DEPP1 321.1531939 280.9117483 361.3946395 1.286505964 0.363458145 0.239012978 1 7.071577223 8.945389815 11067 DEPP1 autophagy regulator "GO:0005737,GO:0005739,GO:0005777,GO:0006914,GO:0010506,GO:0043231" cytoplasm|mitochondrion|peroxisome|autophagy|regulation of autophagy|intracellular membrane-bounded organelle DEPTOR 76.81260417 98.83931885 54.78588949 0.554292463 -0.851280704 0.09725935 1 2.053278625 1.119072022 64798 DEP domain containing MTOR interacting protein "GO:0005515,GO:0006469,GO:0032007,GO:0035556,GO:0045792,GO:2001236" protein binding|negative regulation of protein kinase activity|negative regulation of TOR signaling|intracellular signal transduction|negative regulation of cell size|regulation of extrinsic apoptotic signaling pathway "hsa04140,hsa04150" Autophagy - animal|mTOR signaling pathway DERA 746.6113163 612.8037769 880.4188557 1.436705988 0.522764854 0.039567031 1 17.81275125 25.16344416 51071 deoxyribose-phosphate aldolase "GO:0004139,GO:0005515,GO:0005576,GO:0005654,GO:0005829,GO:0006098,GO:0009264,GO:0016052,GO:0034774,GO:0043312,GO:0046121,GO:0046386,GO:1904813" deoxyribose-phosphate aldolase activity|protein binding|extracellular region|nucleoplasm|cytosol|pentose-phosphate shunt|deoxyribonucleotide catabolic process|carbohydrate catabolic process|secretory granule lumen|neutrophil degranulation|deoxyribonucleoside catabolic process|deoxyribose phosphate catabolic process|ficolin-1-rich granule lumen hsa00030 Pentose phosphate pathway DERL1 2484.172695 2323.2442 2645.101191 1.138537736 0.187182109 0.428777756 1 37.9979384 42.53815432 79139 derlin 1 "GO:0000839,GO:0002020,GO:0005047,GO:0005515,GO:0005769,GO:0005770,GO:0005783,GO:0005789,GO:0006457,GO:0006986,GO:0016020,GO:0016021,GO:0016032,GO:0016567,GO:0030176,GO:0030433,GO:0030968,GO:0030970,GO:0031398,GO:0031625,GO:0031648,GO:0032092,GO:0036502,GO:0036503,GO:0036513,GO:0038023,GO:0042288,GO:0042802,GO:0044322,GO:0044877,GO:0045184,GO:0051117,GO:0051787,GO:0055085,GO:0071712,GO:1990381" "Hrd1p ubiquitin ligase ERAD-L complex|protease binding|signal recognition particle binding|protein binding|early endosome|late endosome|endoplasmic reticulum|endoplasmic reticulum membrane|protein folding|response to unfolded protein|membrane|integral component of membrane|viral process|protein ubiquitination|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|retrograde protein transport, ER to cytosol|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|protein destabilization|positive regulation of protein binding|Derlin-1-VIMP complex|ERAD pathway|Derlin-1 retrotranslocation complex|signaling receptor activity|MHC class I protein binding|identical protein binding|endoplasmic reticulum quality control compartment|protein-containing complex binding|establishment of protein localization|ATPase binding|misfolded protein binding|transmembrane transport|ER-associated misfolded protein catabolic process|ubiquitin-specific protease binding" "hsa04141,hsa05014,hsa05022" Protein processing in endoplasmic reticulum|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases DERL2 618.7178235 661.7032294 575.7324176 0.870076482 -0.200785872 0.444327531 1 8.474654474 7.250210378 51009 derlin 2 "GO:0000839,GO:0001967,GO:0005047,GO:0005515,GO:0005769,GO:0005770,GO:0005783,GO:0005789,GO:0008284,GO:0016020,GO:0016032,GO:0030176,GO:0030307,GO:0030433,GO:0030968,GO:0030970,GO:0044322,GO:0044877,GO:0051787,GO:1904153,GO:1904380,GO:1990381" "Hrd1p ubiquitin ligase ERAD-L complex|suckling behavior|signal recognition particle binding|protein binding|early endosome|late endosome|endoplasmic reticulum|endoplasmic reticulum membrane|positive regulation of cell population proliferation|membrane|viral process|integral component of endoplasmic reticulum membrane|positive regulation of cell growth|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|retrograde protein transport, ER to cytosol|endoplasmic reticulum quality control compartment|protein-containing complex binding|misfolded protein binding|negative regulation of retrograde protein transport, ER to cytosol|endoplasmic reticulum mannose trimming|ubiquitin-specific protease binding" hsa04141 Protein processing in endoplasmic reticulum DERL3 7.927021428 6.242483296 9.61155956 1.539701286 0.622650484 0.695278173 1 0.094483795 0.143042463 91319 derlin 3 "GO:0000839,GO:0005047,GO:0005515,GO:0018279,GO:0030176,GO:0030433,GO:0030968,GO:0044877,GO:0051787,GO:1904153,GO:1990381" "Hrd1p ubiquitin ligase ERAD-L complex|signal recognition particle binding|protein binding|protein N-linked glycosylation via asparagine|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|protein-containing complex binding|misfolded protein binding|negative regulation of retrograde protein transport, ER to cytosol|ubiquitin-specific protease binding" hsa04141 Protein processing in endoplasmic reticulum DESI1 1171.745533 1251.617901 1091.873166 0.872369407 -0.196988918 0.417513482 1 14.18185711 12.16479265 27351 desumoylating isopeptidase 1 "GO:0005515,GO:0005634,GO:0005829,GO:0006611,GO:0016926,GO:0032434,GO:0032991,GO:0042802,GO:0061676,GO:0070140,GO:0070646" protein binding|nucleus|cytosol|protein export from nucleus|protein desumoylation|regulation of proteasomal ubiquitin-dependent protein catabolic process|protein-containing complex|identical protein binding|importin-alpha family protein binding|SUMO-specific isopeptidase activity|protein modification by small protein removal DESI2 2151.191907 2274.344747 2028.039067 0.891702575 -0.165365512 0.48482195 1 20.2498497 17.7546863 51029 desumoylating isopeptidase 2 "GO:0004843,GO:0005515,GO:0005737,GO:0016579,GO:0018215,GO:0061578,GO:0070536,GO:0070646,GO:0071108,GO:0101005,GO:1990380" thiol-dependent ubiquitin-specific protease activity|protein binding|cytoplasm|protein deubiquitination|protein phosphopantetheinylation|Lys63-specific deubiquitinase activity|protein K63-linked deubiquitination|protein modification by small protein removal|protein K48-linked deubiquitination|ubiquitinyl hydrolase activity|Lys48-specific deubiquitinase activity DET1 61.0032207 74.90979955 47.09664184 0.628711359 -0.669530267 0.23145535 1 1.572698003 0.972227319 55070 DET1 partner of COP1 E3 ubiquitin ligase "GO:0005515,GO:0005634,GO:0016567,GO:0031461,GO:0031464,GO:0031625,GO:0032436,GO:0044877,GO:0065003,GO:0080008,GO:1990756" protein binding|nucleus|protein ubiquitination|cullin-RING ubiquitin ligase complex|Cul4A-RING E3 ubiquitin ligase complex|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein-containing complex binding|protein-containing complex assembly|Cul4-RING E3 ubiquitin ligase complex|ubiquitin ligase-substrate adaptor activity hsa04120 Ubiquitin mediated proteolysis DEXI 309.9659222 315.2454064 304.686438 0.96650556 -0.049150063 0.884876736 1 10.72279665 10.19022106 28955 Dexi homolog GO:0005515 protein binding DFFA 2864.91633 2805.996241 2923.836418 1.041995843 0.059349522 0.803117934 1 20.26398677 20.7616592 1676 DNA fragmentation factor subunit alpha "GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006309,GO:0019904,GO:0032076,GO:0032991,GO:0042981,GO:0043065,GO:0044183,GO:0060703,GO:0061077,GO:0070242,GO:1900118,GO:1902511" chromatin|protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|apoptotic DNA fragmentation|protein domain specific binding|negative regulation of deoxyribonuclease activity|protein-containing complex|regulation of apoptotic process|positive regulation of apoptotic process|protein folding chaperone|deoxyribonuclease inhibitor activity|chaperone-mediated protein folding|thymocyte apoptotic process|negative regulation of execution phase of apoptosis|negative regulation of apoptotic DNA fragmentation hsa04210 Apoptosis DFFB 141.0314157 144.6175297 137.4453017 0.950405542 -0.073384846 0.876262657 1 2.387247684 2.23088724 1677 DNA fragmentation factor subunit beta "GO:0000785,GO:0004536,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006308,GO:0006309,GO:0019899,GO:0019904,GO:0030263,GO:0032991,GO:0042802,GO:0097718" chromatin|deoxyribonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|DNA catabolic process|apoptotic DNA fragmentation|enzyme binding|protein domain specific binding|apoptotic chromosome condensation|protein-containing complex|identical protein binding|disordered domain specific binding hsa04210 Apoptosis DGAT1 531.6696572 521.2473552 542.0919592 1.039989851 0.056569449 0.840256645 1 7.210475204 7.373338417 8694 diacylglycerol O-acyltransferase 1 "GO:0003846,GO:0004144,GO:0005515,GO:0005789,GO:0005886,GO:0006640,GO:0006641,GO:0008374,GO:0016021,GO:0016746,GO:0019432,GO:0019915,GO:0034379,GO:0035336,GO:0035579,GO:0036155,GO:0042572,GO:0042802,GO:0043312,GO:0046339,GO:0050252,GO:0055089" "2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity|protein binding|endoplasmic reticulum membrane|plasma membrane|monoacylglycerol biosynthetic process|triglyceride metabolic process|O-acyltransferase activity|integral component of membrane|transferase activity, transferring acyl groups|triglyceride biosynthetic process|lipid storage|very-low-density lipoprotein particle assembly|long-chain fatty-acyl-CoA metabolic process|specific granule membrane|acylglycerol acyl-chain remodeling|retinol metabolic process|identical protein binding|neutrophil degranulation|diacylglycerol metabolic process|retinol O-fatty-acyltransferase activity|fatty acid homeostasis" "hsa00561,hsa00830,hsa04975" Glycerolipid metabolism|Retinol metabolism|Fat digestion and absorption DGAT2 38.70854973 44.73779695 32.6793025 0.730462936 -0.453117023 0.506662924 1 0.958480128 0.68841841 84649 diacylglycerol O-acyltransferase 2 "GO:0003846,GO:0004144,GO:0005515,GO:0005739,GO:0005783,GO:0005789,GO:0005811,GO:0005829,GO:0006071,GO:0006629,GO:0006640,GO:0006651,GO:0008374,GO:0010867,GO:0016021,GO:0019432,GO:0019915,GO:0030176,GO:0034383,GO:0035336,GO:0035356,GO:0036155,GO:0038183,GO:0042572,GO:0042632,GO:0042803,GO:0043231,GO:0045722,GO:0046322,GO:0046339,GO:0048471,GO:0050252,GO:0050746,GO:0055089,GO:0060613,GO:0071400,GO:0090181,GO:0097006,GO:1990578" 2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity|protein binding|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|cytosol|glycerol metabolic process|lipid metabolic process|monoacylglycerol biosynthetic process|diacylglycerol biosynthetic process|O-acyltransferase activity|positive regulation of triglyceride biosynthetic process|integral component of membrane|triglyceride biosynthetic process|lipid storage|integral component of endoplasmic reticulum membrane|low-density lipoprotein particle clearance|long-chain fatty-acyl-CoA metabolic process|cellular triglyceride homeostasis|acylglycerol acyl-chain remodeling|bile acid signaling pathway|retinol metabolic process|cholesterol homeostasis|protein homodimerization activity|intracellular membrane-bounded organelle|positive regulation of gluconeogenesis|negative regulation of fatty acid oxidation|diacylglycerol metabolic process|perinuclear region of cytoplasm|retinol O-fatty-acyltransferase activity|regulation of lipoprotein metabolic process|fatty acid homeostasis|fat pad development|cellular response to oleic acid|regulation of cholesterol metabolic process|regulation of plasma lipoprotein particle levels|perinuclear endoplasmic reticulum membrane "hsa00561,hsa04975" Glycerolipid metabolism|Fat digestion and absorption DGCR2 1379.111801 1358.780531 1399.443072 1.029925761 0.042540349 0.862002574 1 16.33970698 16.54707989 9993 DiGeorge syndrome critical region gene 2 "GO:0007155,GO:0009887,GO:0016020,GO:0016021,GO:0030246,GO:0050890" cell adhesion|animal organ morphogenesis|membrane|integral component of membrane|carbohydrate binding|cognition DGCR6L 545.4529331 504.6007331 586.3051332 1.161918909 0.216509385 0.421239836 1 22.9774861 26.25122111 85359 DiGeorge syndrome critical region gene 6 like "GO:0005515,GO:0005634" protein binding|nucleus DGCR8 633.3081556 729.3301317 537.2861794 0.736684467 -0.440881271 0.09024212 1 9.289500878 6.728915453 54487 DGCR8 microprocessor complex subunit "GO:0003725,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0010586,GO:0016604,GO:0020037,GO:0031053,GO:0042802,GO:0042803,GO:0046872,GO:0070877,GO:0070878,GO:0140517" double-stranded RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|miRNA metabolic process|nuclear body|heme binding|primary miRNA processing|identical protein binding|protein homodimerization activity|metal ion binding|microprocessor complex|primary miRNA binding|protein-RNA adaptor activity DGKA 2221.036073 1975.745963 2466.326183 1.248301264 0.319966155 0.175974939 1 27.52334398 33.7825001 1606 diacylglycerol kinase alpha "GO:0003951,GO:0004143,GO:0005509,GO:0005524,GO:0005543,GO:0005829,GO:0005886,GO:0006654,GO:0007205,GO:0008289,GO:0016020,GO:0016301,GO:0030168,GO:0035556,GO:0046339,GO:0046486,GO:0046834" NAD+ kinase activity|diacylglycerol kinase activity|calcium ion binding|ATP binding|phospholipid binding|cytosol|plasma membrane|phosphatidic acid biosynthetic process|protein kinase C-activating G protein-coupled receptor signaling pathway|lipid binding|membrane|kinase activity|platelet activation|intracellular signal transduction|diacylglycerol metabolic process|glycerolipid metabolic process|lipid phosphorylation "hsa00561,hsa00564,hsa04070,hsa04072,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKD 1118.614614 1219.36507 1017.864157 0.834749315 -0.26058509 0.28473213 1 6.501675763 5.336451387 8527 diacylglycerol kinase delta "GO:0003951,GO:0004143,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005905,GO:0006654,GO:0006897,GO:0007165,GO:0007173,GO:0007205,GO:0007275,GO:0010033,GO:0015031,GO:0019900,GO:0019932,GO:0019992,GO:0030168,GO:0035556,GO:0042802,GO:0042803,GO:0045742,GO:0046339,GO:0046834,GO:0046872,GO:0046982,GO:0090038,GO:2000370" NAD+ kinase activity|diacylglycerol kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|clathrin-coated pit|phosphatidic acid biosynthetic process|endocytosis|signal transduction|epidermal growth factor receptor signaling pathway|protein kinase C-activating G protein-coupled receptor signaling pathway|multicellular organism development|response to organic substance|protein transport|kinase binding|second-messenger-mediated signaling|diacylglycerol binding|platelet activation|intracellular signal transduction|identical protein binding|protein homodimerization activity|positive regulation of epidermal growth factor receptor signaling pathway|diacylglycerol metabolic process|lipid phosphorylation|metal ion binding|protein heterodimerization activity|negative regulation of protein kinase C signaling|positive regulation of clathrin-dependent endocytosis "hsa00561,hsa00564,hsa04070,hsa04072,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKE 639.4619345 663.7840571 615.1398118 0.926716762 -0.109799629 0.676696317 1 3.917820742 3.569955133 8526 diacylglycerol kinase epsilon "GO:0003951,GO:0004143,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006654,GO:0006661,GO:0007205,GO:0016020,GO:0016021,GO:0016301,GO:0030168,GO:0035556,GO:0046339,GO:0046834,GO:0046872,GO:0050804,GO:0098978" NAD+ kinase activity|diacylglycerol kinase activity|ATP binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|phosphatidic acid biosynthetic process|phosphatidylinositol biosynthetic process|protein kinase C-activating G protein-coupled receptor signaling pathway|membrane|integral component of membrane|kinase activity|platelet activation|intracellular signal transduction|diacylglycerol metabolic process|lipid phosphorylation|metal ion binding|modulation of chemical synaptic transmission|glutamatergic synapse "hsa00561,hsa00564,hsa04070,hsa04072,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKG 36.14714399 40.57614142 31.71814655 0.781694499 -0.355323209 0.622061862 1 0.373228902 0.286868922 1608 diacylglycerol kinase gamma "GO:0003951,GO:0004143,GO:0005509,GO:0005524,GO:0005829,GO:0005856,GO:0005886,GO:0006654,GO:0007205,GO:0008289,GO:0016020,GO:0030168,GO:0035556,GO:0046339,GO:0046486,GO:0046834,GO:0048666,GO:0050773,GO:0090038" NAD+ kinase activity|diacylglycerol kinase activity|calcium ion binding|ATP binding|cytosol|cytoskeleton|plasma membrane|phosphatidic acid biosynthetic process|protein kinase C-activating G protein-coupled receptor signaling pathway|lipid binding|membrane|platelet activation|intracellular signal transduction|diacylglycerol metabolic process|glycerolipid metabolic process|lipid phosphorylation|neuron development|regulation of dendrite development|negative regulation of protein kinase C signaling "hsa00561,hsa00564,hsa04070,hsa04072,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKH 1321.5563 1374.386739 1268.725862 0.923121437 -0.115407647 0.632881818 1 4.145387942 3.762661892 160851 diacylglycerol kinase eta "GO:0003951,GO:0004143,GO:0005524,GO:0005737,GO:0005768,GO:0005886,GO:0006654,GO:0007205,GO:0015629,GO:0030168,GO:0035556,GO:0043231,GO:0046339,GO:0046473,GO:0046834,GO:0046872" NAD+ kinase activity|diacylglycerol kinase activity|ATP binding|cytoplasm|endosome|plasma membrane|phosphatidic acid biosynthetic process|protein kinase C-activating G protein-coupled receptor signaling pathway|actin cytoskeleton|platelet activation|intracellular signal transduction|intracellular membrane-bounded organelle|diacylglycerol metabolic process|phosphatidic acid metabolic process|lipid phosphorylation|metal ion binding "hsa00561,hsa00564,hsa04070,hsa04072,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKI 9.125951164 12.48496659 5.766935736 0.461910386 -1.11431511 0.374388992 1 0.048895554 0.022207429 9162 diacylglycerol kinase iota "GO:0003951,GO:0004143,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007205,GO:0014069,GO:0030168,GO:0030424,GO:0030672,GO:0032991,GO:0035556,GO:0043197,GO:0045202,GO:0046339,GO:0046834,GO:0046872,GO:0051966,GO:0097060" "NAD+ kinase activity|diacylglycerol kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|protein kinase C-activating G protein-coupled receptor signaling pathway|postsynaptic density|platelet activation|axon|synaptic vesicle membrane|protein-containing complex|intracellular signal transduction|dendritic spine|synapse|diacylglycerol metabolic process|lipid phosphorylation|metal ion binding|regulation of synaptic transmission, glutamatergic|synaptic membrane" "hsa00561,hsa00564,hsa04070,hsa04072,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKQ 540.0426581 513.964458 566.1208581 1.101478612 0.139441482 0.607609586 1 5.718019283 6.192882827 1609 diacylglycerol kinase theta "GO:0003951,GO:0004143,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005768,GO:0005829,GO:0005856,GO:0005886,GO:0006111,GO:0006357,GO:0006654,GO:0007171,GO:0007186,GO:0007205,GO:0008277,GO:0010628,GO:0010629,GO:0010801,GO:0012506,GO:0016363,GO:0016607,GO:0018105,GO:0019900,GO:0019933,GO:0030168,GO:0030297,GO:0033198,GO:0033613,GO:0035556,GO:0043274,GO:0046339,GO:0046486,GO:0046834,GO:0046872,GO:0050731,GO:0051591,GO:0070493,GO:0070528,GO:0090181,GO:0098793,GO:0098794,GO:0098978,GO:1900242,GO:1903432,GO:2000064,GO:2000182" NAD+ kinase activity|diacylglycerol kinase activity|protein binding|ATP binding|nucleus|cytoplasm|endosome|cytosol|cytoskeleton|plasma membrane|regulation of gluconeogenesis|regulation of transcription by RNA polymerase II|phosphatidic acid biosynthetic process|activation of transmembrane receptor protein tyrosine kinase activity|G protein-coupled receptor signaling pathway|protein kinase C-activating G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|positive regulation of gene expression|negative regulation of gene expression|negative regulation of peptidyl-threonine phosphorylation|vesicle membrane|nuclear matrix|nuclear speck|peptidyl-serine phosphorylation|kinase binding|cAMP-mediated signaling|platelet activation|transmembrane receptor protein tyrosine kinase activator activity|response to ATP|activating transcription factor binding|intracellular signal transduction|phospholipase binding|diacylglycerol metabolic process|glycerolipid metabolic process|lipid phosphorylation|metal ion binding|positive regulation of peptidyl-tyrosine phosphorylation|response to cAMP|thrombin-activated receptor signaling pathway|protein kinase C signaling|regulation of cholesterol metabolic process|presynapse|postsynapse|glutamatergic synapse|regulation of synaptic vesicle endocytosis|regulation of TORC1 signaling|regulation of cortisol biosynthetic process|regulation of progesterone biosynthetic process "hsa00561,hsa00564,hsa04070,hsa04072,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKZ 836.7404809 859.3818671 814.0990947 0.947307741 -0.078094922 0.758769527 1 8.008316879 7.459393433 8525 diacylglycerol kinase zeta "GO:0003951,GO:0004143,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006654,GO:0007205,GO:0014069,GO:0016301,GO:0016477,GO:0016607,GO:0030027,GO:0030168,GO:0035556,GO:0046339,GO:0046486,GO:0046834,GO:0046872,GO:0050860,GO:0051966,GO:0090216,GO:0098978" "NAD+ kinase activity|diacylglycerol kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|phosphatidic acid biosynthetic process|protein kinase C-activating G protein-coupled receptor signaling pathway|postsynaptic density|kinase activity|cell migration|nuclear speck|lamellipodium|platelet activation|intracellular signal transduction|diacylglycerol metabolic process|glycerolipid metabolic process|lipid phosphorylation|metal ion binding|negative regulation of T cell receptor signaling pathway|regulation of synaptic transmission, glutamatergic|positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity|glutamatergic synapse" "hsa00561,hsa00564,hsa04070,hsa04072,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGLUCY 376.2951297 391.1956199 361.3946395 0.923820772 -0.11431511 0.703954349 1 4.777435068 4.33963991 80017 D-glutamate cyclase "GO:0003674,GO:0005515,GO:0005575,GO:0005759,GO:0006536,GO:0008150,GO:0047820" molecular_function|protein binding|cellular_component|mitochondrial matrix|glutamate metabolic process|biological_process|D-glutamate cyclase activity hsa00471 D-Glutamine and D-glutamate metabolism DGUOK 990.9512916 895.796353 1086.10623 1.212447703 0.27792252 0.258948647 1 40.07292955 47.77330492 1716 deoxyguanosine kinase "GO:0004136,GO:0004138,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006170,GO:0006468,GO:0006754,GO:0008617,GO:0010977,GO:0019136,GO:0042775,GO:0043101,GO:0046070,GO:0046122" deoxyadenosine kinase activity|deoxyguanosine kinase activity|ATP binding|nucleus|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|dAMP biosynthetic process|protein phosphorylation|ATP biosynthetic process|guanosine metabolic process|negative regulation of neuron projection development|deoxynucleoside kinase activity|mitochondrial ATP synthesis coupled electron transport|purine-containing compound salvage|dGTP metabolic process|purine deoxyribonucleoside metabolic process hsa00230 Purine metabolism DHCR24 5717.5213 5553.729306 5881.313295 1.058984508 0.082681484 0.732557008 1 70.01944855 72.9087196 1718 24-dehydrocholesterol reductase "GO:0000139,GO:0000246,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0006695,GO:0006915,GO:0006979,GO:0007050,GO:0008202,GO:0009888,GO:0016020,GO:0016021,GO:0016628,GO:0019899,GO:0033489,GO:0033490,GO:0042605,GO:0043066,GO:0043154,GO:0043588,GO:0050614,GO:0055114,GO:0071949,GO:1901214" "Golgi membrane|delta24(24-1) sterol reductase activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol biosynthetic process|apoptotic process|response to oxidative stress|cell cycle arrest|steroid metabolic process|tissue development|membrane|integral component of membrane|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor|enzyme binding|cholesterol biosynthetic process via desmosterol|cholesterol biosynthetic process via lathosterol|peptide antigen binding|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|skin development|delta24-sterol reductase activity|oxidation-reduction process|FAD binding|regulation of neuron death" hsa00100 Steroid biosynthesis DHCR7 553.6668037 594.076327 513.2572805 0.86395848 -0.210966114 0.431679305 1 11.48307197 9.754884622 1717 7-dehydrocholesterol reductase "GO:0005515,GO:0005640,GO:0005783,GO:0005789,GO:0006695,GO:0009918,GO:0016020,GO:0016126,GO:0016132,GO:0016627,GO:0030176,GO:0033489,GO:0033490,GO:0045540,GO:0047598,GO:0050661,GO:0055114" "protein binding|nuclear outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol biosynthetic process|sterol delta7 reductase activity|membrane|sterol biosynthetic process|brassinosteroid biosynthetic process|oxidoreductase activity, acting on the CH-CH group of donors|integral component of endoplasmic reticulum membrane|cholesterol biosynthetic process via desmosterol|cholesterol biosynthetic process via lathosterol|regulation of cholesterol biosynthetic process|7-dehydrocholesterol reductase activity|NADP binding|oxidation-reduction process" hsa00100 Steroid biosynthesis DHDDS 463.8836246 482.7520415 445.0152076 0.921829779 -0.117427722 0.678170534 1 7.774166927 7.046537599 79947 dehydrodolichyl diphosphate synthase subunit "GO:0002094,GO:0005515,GO:0005783,GO:0005789,GO:0006489,GO:0016094,GO:0045547,GO:0046872,GO:1904423" polyprenyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|dolichyl diphosphate biosynthetic process|polyprenol biosynthetic process|dehydrodolichyl diphosphate synthase activity|metal ion binding|dehydrodolichyl diphosphate synthase complex hsa00900 Terpenoid backbone biosynthesis DHDH 25.460572 24.96993318 25.95121081 1.039298368 0.055609892 1 1 0.759315921 0.775950344 27294 dihydrodiol dehydrogenase "GO:0005975,GO:0008746,GO:0009055,GO:0022900,GO:0042843,GO:0047115,GO:0047837" "carbohydrate metabolic process|NAD(P)+ transhydrogenase activity|electron transfer activity|electron transport chain|D-xylose catabolic process|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity|D-xylose 1-dehydrogenase (NADP+) activity" "hsa00040,hsa00980" Pentose and glucuronate interconversions|Metabolism of xenobiotics by cytochrome P450 DHFR 1078.148527 964.4636692 1191.833385 1.235747311 0.305383767 0.211300473 1 13.13387431 15.95856028 1719 dihydrofolate reductase "GO:0000083,GO:0000900,GO:0003729,GO:0004146,GO:0005542,GO:0005739,GO:0005829,GO:0006545,GO:0006729,GO:0006730,GO:0008144,GO:0017148,GO:0031103,GO:0031427,GO:0046452,GO:0046653,GO:0046654,GO:0046655,GO:0050661,GO:0051000,GO:0051870,GO:0055114,GO:0070402,GO:1990825,GO:2000121" "regulation of transcription involved in G1/S transition of mitotic cell cycle|translation repressor activity, mRNA regulatory element binding|mRNA binding|dihydrofolate reductase activity|folic acid binding|mitochondrion|cytosol|glycine biosynthetic process|tetrahydrobiopterin biosynthetic process|one-carbon metabolic process|drug binding|negative regulation of translation|axon regeneration|response to methotrexate|dihydrofolate metabolic process|tetrahydrofolate metabolic process|tetrahydrofolate biosynthetic process|folic acid metabolic process|NADP binding|positive regulation of nitric-oxide synthase activity|methotrexate binding|oxidation-reduction process|NADPH binding|sequence-specific mRNA binding|regulation of removal of superoxide radicals" "hsa00670,hsa00790,hsa01523" One carbon pool by folate|Folate biosynthesis|Antifolate resistance DHFR2 193.735863 241.3760208 146.0957053 0.605261885 -0.724368592 0.048814214 1 3.213218907 1.912294687 200895 dihydrofolate reductase 2 "GO:0003729,GO:0004146,GO:0005739,GO:0005743,GO:0005759,GO:0006545,GO:0006730,GO:0046105,GO:0046452,GO:0046653,GO:0046654,GO:0046655,GO:0050661,GO:0055114" mRNA binding|dihydrofolate reductase activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|glycine biosynthetic process|one-carbon metabolic process|thymidine biosynthetic process|dihydrofolate metabolic process|tetrahydrofolate metabolic process|tetrahydrofolate biosynthetic process|folic acid metabolic process|NADP binding|oxidation-reduction process "hsa00670,hsa00790,hsa01523" One carbon pool by folate|Folate biosynthesis|Antifolate resistance DHH 13.411524 11.44455271 15.3784953 1.343739304 0.426253271 0.726340813 1 0.111414583 0.147206924 50846 desert hedgehog signaling molecule "GO:0001649,GO:0001708,GO:0005113,GO:0005509,GO:0005515,GO:0005615,GO:0005886,GO:0007224,GO:0007267,GO:0007286,GO:0008233,GO:0008270,GO:0010468,GO:0016540,GO:0030238,GO:0032355,GO:0033327,GO:0042552,GO:0043627,GO:0050810" osteoblast differentiation|cell fate specification|patched binding|calcium ion binding|protein binding|extracellular space|plasma membrane|smoothened signaling pathway|cell-cell signaling|spermatid development|peptidase activity|zinc ion binding|regulation of gene expression|protein autoprocessing|male sex determination|response to estradiol|Leydig cell differentiation|myelination|response to estrogen|regulation of steroid biosynthetic process hsa04340 Hedgehog signaling pathway DHODH 145.9164534 146.6983575 145.1345494 0.989339975 -0.015461723 0.988890652 1 2.635146993 2.563430706 1723 dihydroorotate dehydrogenase (quinone) "GO:0004152,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005829,GO:0006207,GO:0007565,GO:0007595,GO:0008144,GO:0009220,GO:0010181,GO:0016021,GO:0031000,GO:0042493,GO:0042594,GO:0043025,GO:0043065,GO:0044205,GO:0046134,GO:0048039,GO:0055114,GO:0090140,GO:1903576" dihydroorotate dehydrogenase activity|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|cytosol|'de novo' pyrimidine nucleobase biosynthetic process|female pregnancy|lactation|drug binding|pyrimidine ribonucleotide biosynthetic process|FMN binding|integral component of membrane|response to caffeine|response to drug|response to starvation|neuronal cell body|positive regulation of apoptotic process|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process|ubiquinone binding|oxidation-reduction process|regulation of mitochondrial fission|response to L-arginine hsa00240 Pyrimidine metabolism DHPS 1340.58692 1255.779556 1425.394283 1.135067278 0.182777812 0.447475655 1 39.8209429 44.44309769 1725 deoxyhypusine synthase "GO:0005515,GO:0005737,GO:0005829,GO:0006412,GO:0008216,GO:0008284,GO:0008612,GO:0034038,GO:0042802" protein binding|cytoplasm|cytosol|translation|spermidine metabolic process|positive regulation of cell population proliferation|peptidyl-lysine modification to peptidyl-hypusine|deoxyhypusine synthase activity|identical protein binding DHRS1 720.5852636 699.1581291 742.012398 1.061294101 0.085824505 0.740750317 1 22.31625858 23.28779202 115817 dehydrogenase/reductase 1 "GO:0005515,GO:0005783,GO:0016491,GO:0055114" protein binding|endoplasmic reticulum|oxidoreductase activity|oxidation-reduction process DHRS11 172.1846959 155.0216685 189.3477233 1.221427463 0.288568189 0.458752422 1 5.344458353 6.418633175 79154 dehydrogenase/reductase 11 "GO:0000166,GO:0000253,GO:0004303,GO:0005575,GO:0005576,GO:0006694,GO:0006703,GO:0055114,GO:0072555,GO:0072582" nucleotide binding|3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity|cellular_component|extracellular region|steroid biosynthetic process|estrogen biosynthetic process|oxidation-reduction process|17-beta-ketosteroid reductase activity|17-beta-hydroxysteroid dehydrogenase (NADP+) activity hsa00140 Steroid hormone biosynthesis DHRS12 82.54494136 85.31393838 79.77594435 0.935086879 -0.096827683 0.869871651 1 1.736479058 1.596587378 79758 dehydrogenase/reductase 12 "GO:0016491,GO:0055114" oxidoreductase activity|oxidation-reduction process DHRS13 208.0443763 213.2848459 202.8039067 0.950859428 -0.072696021 0.851735119 1 5.900788091 5.516930517 147015 dehydrogenase/reductase 13 "GO:0005576,GO:0005743,GO:0016020,GO:0042572,GO:0042574,GO:0052650,GO:0055114" extracellular region|mitochondrial inner membrane|membrane|retinol metabolic process|retinal metabolic process|NADP-retinol dehydrogenase activity|oxidation-reduction process DHRS2 35.02244176 48.89945248 21.14543103 0.432426744 -1.209472343 0.078189388 1 1.015437317 0.431754472 10202 dehydrogenase/reductase 2 "GO:0004090,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0008207,GO:0008285,GO:0009636,GO:0034599,GO:0043011,GO:0043066,GO:0055114" carbonyl reductase (NADPH) activity|protein binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|mitochondrion|mitochondrial matrix|C21-steroid hormone metabolic process|negative regulation of cell population proliferation|response to toxic substance|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptotic process|oxidation-reduction process DHRS3 1325.460061 1426.407433 1224.512688 0.858459273 -0.220178403 0.360032729 1 31.43052976 26.53032535 9249 dehydrogenase/reductase 3 "GO:0000166,GO:0001523,GO:0003151,GO:0004745,GO:0005789,GO:0005811,GO:0007601,GO:0009055,GO:0016021,GO:0016616,GO:0022900,GO:0030278,GO:0042572,GO:0042622,GO:0048385,GO:0048387,GO:0052650,GO:0060021,GO:0060349,GO:0060411" "nucleotide binding|retinoid metabolic process|outflow tract morphogenesis|retinol dehydrogenase activity|endoplasmic reticulum membrane|lipid droplet|visual perception|electron transfer activity|integral component of membrane|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|electron transport chain|regulation of ossification|retinol metabolic process|photoreceptor outer segment membrane|regulation of retinoic acid receptor signaling pathway|negative regulation of retinoic acid receptor signaling pathway|NADP-retinol dehydrogenase activity|roof of mouth development|bone morphogenesis|cardiac septum morphogenesis" hsa00830 Retinol metabolism DHRS4 270.0685036 239.295193 300.8418142 1.257199572 0.330213686 0.31363006 1 9.523299511 11.77234135 10901 dehydrogenase/reductase 4 "GO:0000253,GO:0004090,GO:0005634,GO:0005739,GO:0005777,GO:0005778,GO:0005782,GO:0005789,GO:0005829,GO:0006066,GO:0006625,GO:0008202,GO:0016655,GO:0018455,GO:0042180,GO:0042802,GO:0055114" "3-keto sterol reductase activity|carbonyl reductase (NADPH) activity|nucleus|mitochondrion|peroxisome|peroxisomal membrane|peroxisomal matrix|endoplasmic reticulum membrane|cytosol|alcohol metabolic process|protein targeting to peroxisome|steroid metabolic process|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|alcohol dehydrogenase [NAD(P)+] activity|cellular ketone metabolic process|identical protein binding|oxidation-reduction process" "hsa00830,hsa04146" Retinol metabolism|Peroxisome DHRS4L2 180.5922953 161.2641518 199.9204388 1.239707874 0.310000203 0.416368954 1 4.690120649 5.717083734 317749 dehydrogenase/reductase 4 like 2 "GO:0005576,GO:0016491,GO:0055114" extracellular region|oxidoreductase activity|oxidation-reduction process hsa00830 Retinol metabolism DHRS7 1776.340355 1580.388688 1972.292022 1.247979081 0.319593751 0.17788748 1 32.64026302 40.05273099 51635 dehydrogenase/reductase 7 "GO:0005515,GO:0016020,GO:0016491,GO:0055114" protein binding|membrane|oxidoreductase activity|oxidation-reduction process DHRS7B 160.685423 168.547049 152.823797 0.90671298 -0.141282158 0.732593261 1 3.628497873 3.234952322 25979 dehydrogenase/reductase 7B "GO:0003674,GO:0005789,GO:0008150,GO:0016020,GO:0016021,GO:0016491,GO:0055114" molecular_function|endoplasmic reticulum membrane|biological_process|membrane|integral component of membrane|oxidoreductase activity|oxidation-reduction process DHTKD1 981.3737162 1010.24188 952.5055524 0.942849006 -0.084901348 0.733290878 1 10.4223376 9.662254284 55526 dehydrogenase E1 and transketolase domain containing 1 "GO:0002244,GO:0004591,GO:0005515,GO:0005739,GO:0005759,GO:0006091,GO:0006096,GO:0006099,GO:0030976" hematopoietic progenitor cell differentiation|oxoglutarate dehydrogenase (succinyl-transferring) activity|protein binding|mitochondrion|mitochondrial matrix|generation of precursor metabolites and energy|glycolytic process|tricarboxylic acid cycle|thiamine pyrophosphate binding "hsa00310,hsa00380" Lysine degradation|Tryptophan metabolism DHX15 3626.702966 3426.082916 3827.323017 1.117113366 0.159775599 0.501473865 1 60.98857516 66.99106989 1665 DEAH-box helicase 15 "GO:0000398,GO:0003723,GO:0003724,GO:0003725,GO:0005515,GO:0005524,GO:0005622,GO:0005634,GO:0005654,GO:0005681,GO:0005689,GO:0005730,GO:0006397,GO:0008380,GO:0009636,GO:0016607,GO:0043279,GO:0071008" "mRNA splicing, via spliceosome|RNA binding|RNA helicase activity|double-stranded RNA binding|protein binding|ATP binding|intracellular anatomical structure|nucleus|nucleoplasm|spliceosomal complex|U12-type spliceosomal complex|nucleolus|mRNA processing|RNA splicing|response to toxic substance|nuclear speck|response to alkaloid|U2-type post-mRNA release spliceosomal complex" hsa03040 Spliceosome DHX16 971.3067308 947.8170471 994.7964145 1.04956586 0.069792699 0.780488913 1 10.22503614 10.5522659 8449 DEAH-box helicase 16 "GO:0000398,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005622,GO:0005634,GO:0005654,GO:0005681,GO:0008380,GO:0016887,GO:0071005" "mRNA splicing, via spliceosome|RNA binding|RNA helicase activity|protein binding|ATP binding|intracellular anatomical structure|nucleus|nucleoplasm|spliceosomal complex|RNA splicing|ATPase activity|U2-type precatalytic spliceosome" hsa03040 Spliceosome DHX29 1276.670048 1255.779556 1297.560541 1.033270954 0.047218621 0.847642085 1 14.10621909 14.33164443 54505 DExH-box helicase 29 "GO:0001731,GO:0003723,GO:0003724,GO:0003743,GO:0005524,GO:0005622,GO:0008494,GO:0016282,GO:0017111,GO:0022627,GO:0042255,GO:0043024,GO:0045296,GO:0045948" formation of translation preinitiation complex|RNA binding|RNA helicase activity|translation initiation factor activity|ATP binding|intracellular anatomical structure|translation activator activity|eukaryotic 43S preinitiation complex|nucleoside-triphosphatase activity|cytosolic small ribosomal subunit|ribosome assembly|ribosomal small subunit binding|cadherin binding|positive regulation of translational initiation DHX30 1672.088918 1694.834215 1649.34362 0.973159266 -0.039252161 0.871154352 1 18.04312529 17.26501125 22907 DExH-box helicase 30 "GO:0003682,GO:0003723,GO:0003724,GO:0003725,GO:0005515,GO:0005524,GO:0005622,GO:0005737,GO:0005739,GO:0005829,GO:0007417,GO:0035770,GO:0042645,GO:1902775" chromatin binding|RNA binding|RNA helicase activity|double-stranded RNA binding|protein binding|ATP binding|intracellular anatomical structure|cytoplasm|mitochondrion|cytosol|central nervous system development|ribonucleoprotein granule|mitochondrial nucleoid|mitochondrial large ribosomal subunit assembly DHX32 880.8247071 881.2305586 880.4188557 0.999078898 -0.001329481 1 1 15.41955911 15.14756836 55760 DEAH-box helicase 32 (putative) "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005622,GO:0005681,GO:0005739" RNA binding|RNA helicase activity|protein binding|ATP binding|intracellular anatomical structure|spliceosomal complex|mitochondrion DHX33 958.0128649 1141.334029 774.6917005 0.678759838 -0.559026892 0.023562552 0.846928903 11.27562004 7.525368109 56919 DEAH-box helicase 33 "GO:0000182,GO:0003723,GO:0003724,GO:0003725,GO:0003729,GO:0005515,GO:0005524,GO:0005622,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006413,GO:0032481,GO:0033613,GO:0043023,GO:0043410,GO:0045943,GO:0051092,GO:0072559,GO:1900227" rDNA binding|RNA binding|RNA helicase activity|double-stranded RNA binding|mRNA binding|protein binding|ATP binding|intracellular anatomical structure|nucleus|nucleoplasm|nucleolus|cytoplasm|translational initiation|positive regulation of type I interferon production|activating transcription factor binding|ribosomal large subunit binding|positive regulation of MAPK cascade|positive regulation of transcription by RNA polymerase I|positive regulation of NF-kappaB transcription factor activity|NLRP3 inflammasome complex|positive regulation of NLRP3 inflammasome complex assembly hsa04621 NOD-like receptor signaling pathway DHX34 293.3784364 333.9728563 252.7840164 0.756899885 -0.401825608 0.204887681 1 3.074610579 2.288230314 9704 DExH-box helicase 34 "GO:0000184,GO:0000956,GO:0003723,GO:0003724,GO:0005524,GO:0005622,GO:0016020,GO:2000623" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process|RNA binding|RNA helicase activity|ATP binding|intracellular anatomical structure|membrane|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" DHX35 439.2206623 466.1054194 412.3359051 0.884640873 -0.176836194 0.534283576 1 7.143937269 6.214065291 60625 DEAH-box helicase 35 "GO:0000398,GO:0001701,GO:0003723,GO:0003724,GO:0005524,GO:0005622,GO:0071013" "mRNA splicing, via spliceosome|in utero embryonic development|RNA binding|RNA helicase activity|ATP binding|intracellular anatomical structure|catalytic step 2 spliceosome" DHX36 1410.521748 1527.32758 1293.715917 0.847045476 -0.239488668 0.317410402 1 12.1241508 10.09785744 170506 DEAH-box helicase 36 "GO:0000287,GO:0000781,GO:0000976,GO:0000978,GO:0001503,GO:0002151,GO:0002735,GO:0003678,GO:0003697,GO:0003723,GO:0003724,GO:0003725,GO:0003730,GO:0005515,GO:0005524,GO:0005622,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006359,GO:0007283,GO:0008094,GO:0010494,GO:0010501,GO:0010628,GO:0016607,GO:0017148,GO:0030424,GO:0030425,GO:0031442,GO:0032206,GO:0032481,GO:0032508,GO:0032727,GO:0034605,GO:0034644,GO:0035925,GO:0042826,GO:0043123,GO:0043204,GO:0043330,GO:0043488,GO:0044806,GO:0045087,GO:0045944,GO:0045995,GO:0048027,GO:0051607,GO:0051880,GO:0051891,GO:0060261,GO:0061003,GO:0061158,GO:0070034,GO:0070062,GO:0070883,GO:0090669,GO:1900153,GO:1901534,GO:1902064,GO:1903843,GO:1904358,GO:1904582,GO:2000767" "magnesium ion binding|chromosome, telomeric region|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|ossification|G-quadruplex RNA binding|positive regulation of myeloid dendritic cell cytokine production|DNA helicase activity|single-stranded DNA binding|RNA binding|RNA helicase activity|double-stranded RNA binding|mRNA 3'-UTR binding|protein binding|ATP binding|intracellular anatomical structure|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|regulation of transcription by RNA polymerase III|spermatogenesis|DNA-dependent ATPase activity|cytoplasmic stress granule|RNA secondary structure unwinding|positive regulation of gene expression|nuclear speck|negative regulation of translation|axon|dendrite|positive regulation of mRNA 3'-end processing|positive regulation of telomere maintenance|positive regulation of type I interferon production|DNA duplex unwinding|positive regulation of interferon-alpha production|cellular response to heat|cellular response to UV|mRNA 3'-UTR AU-rich region binding|histone deacetylase binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|perikaryon|response to exogenous dsRNA|regulation of mRNA stability|G-quadruplex DNA unwinding|innate immune response|positive regulation of transcription by RNA polymerase II|regulation of embryonic development|mRNA 5'-UTR binding|defense response to virus|G-quadruplex DNA binding|positive regulation of cardioblast differentiation|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of dendritic spine morphogenesis|3'-UTR-mediated mRNA destabilization|telomerase RNA binding|extracellular exosome|pre-miRNA binding|telomerase RNA stabilization|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|positive regulation of hematopoietic progenitor cell differentiation|regulation of transcription from RNA polymerase II promoter involved in spermatogenesis|cellular response to arsenite ion|positive regulation of telomere maintenance via telomere lengthening|positive regulation of intracellular mRNA localization|positive regulation of cytoplasmic translation" hsa03018 RNA degradation DHX37 427.637101 490.0349387 365.2392633 0.745333107 -0.424042751 0.135315066 1 5.354681416 3.924236998 57647 DEAH-box helicase 37 "GO:0000462,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005622,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0007420,GO:0031965,GO:0034511,GO:0042254,GO:0042255,GO:2000020" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|RNA helicase activity|protein binding|ATP binding|intracellular anatomical structure|nucleoplasm|nucleolus|cytoplasm|rRNA processing|brain development|nuclear membrane|U3 snoRNA binding|ribosome biogenesis|ribosome assembly|positive regulation of male gonad development" DHX38 1481.529016 1423.286191 1539.771842 1.081842746 0.113490808 0.63616719 1 17.22407441 18.32192955 9785 DEAH-box helicase 38 "GO:0000398,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005622,GO:0005634,GO:0005654,GO:0005681,GO:0006405,GO:0006406,GO:0016020,GO:0031124,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|RNA helicase activity|protein binding|ATP binding|intracellular anatomical structure|nucleus|nucleoplasm|spliceosomal complex|RNA export from nucleus|mRNA export from nucleus|membrane|mRNA 3'-end processing|catalytic step 2 spliceosome" hsa03040 Spliceosome DHX40 1293.772096 1351.497634 1236.046559 0.914575452 -0.128825898 0.594115458 1 25.21039663 22.67098541 79665 DEAH-box helicase 40 "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005622" RNA binding|RNA helicase activity|protein binding|ATP binding|intracellular anatomical structure DHX57 666.1510043 721.0068207 611.295188 0.847835513 -0.238143697 0.35730749 1 7.582031303 6.320746251 90957 DExH-box helicase 57 "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005622,GO:0046872" RNA binding|RNA helicase activity|protein binding|ATP binding|intracellular anatomical structure|metal ion binding DHX58 164.1236964 183.1128433 145.1345494 0.79259623 -0.335341989 0.396011112 1 3.761507276 2.931467524 79132 DExH-box helicase 58 "GO:0003677,GO:0003724,GO:0003725,GO:0003727,GO:0005515,GO:0005524,GO:0005737,GO:0008270,GO:0009615,GO:0009617,GO:0016032,GO:0032480,GO:0032481,GO:0032728,GO:0039534,GO:0039536,GO:0045087,GO:0045088,GO:0045824,GO:0051607,GO:1900245,GO:1900246" DNA binding|RNA helicase activity|double-stranded RNA binding|single-stranded RNA binding|protein binding|ATP binding|cytoplasm|zinc ion binding|response to virus|response to bacterium|viral process|negative regulation of type I interferon production|positive regulation of type I interferon production|positive regulation of interferon-beta production|negative regulation of MDA-5 signaling pathway|negative regulation of RIG-I signaling pathway|innate immune response|regulation of innate immune response|negative regulation of innate immune response|defense response to virus|positive regulation of MDA-5 signaling pathway|positive regulation of RIG-I signaling pathway hsa04622 RIG-I-like receptor signaling pathway DHX8 1709.746378 1863.381264 1556.111493 0.835100966 -0.259977462 0.273618713 1 14.52391314 11.92597261 1659 DEAH-box helicase 8 "GO:0000390,GO:0000398,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005622,GO:0005634,GO:0005654,GO:0005681,GO:0005829,GO:0006396,GO:0008380,GO:0016604,GO:0042802,GO:0071007,GO:0071013" "spliceosomal complex disassembly|mRNA splicing, via spliceosome|RNA binding|RNA helicase activity|protein binding|ATP binding|intracellular anatomical structure|nucleus|nucleoplasm|spliceosomal complex|cytosol|RNA processing|RNA splicing|nuclear body|identical protein binding|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome DHX9 4580.587545 4774.459307 4386.715783 0.918787972 -0.122196125 0.609797877 1 56.71135503 51.23379236 1660 DExH-box helicase 9 "GO:0000380,GO:0000398,GO:0000978,GO:0000993,GO:0001069,GO:0001085,GO:0001649,GO:0003677,GO:0003678,GO:0003688,GO:0003690,GO:0003697,GO:0003712,GO:0003713,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0003729,GO:0005515,GO:0005524,GO:0005622,GO:0005634,GO:0005654,GO:0005726,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0005844,GO:0006260,GO:0006353,GO:0006357,GO:0006954,GO:0010501,GO:0015629,GO:0016020,GO:0016442,GO:0016604,GO:0016887,GO:0017111,GO:0030423,GO:0031490,GO:0032481,GO:0032508,GO:0032727,GO:0032728,GO:0032741,GO:0032755,GO:0032760,GO:0032991,GO:0033679,GO:0034458,GO:0034622,GO:0035197,GO:0035613,GO:0036464,GO:0039695,GO:0042788,GO:0043138,GO:0044806,GO:0045087,GO:0045089,GO:0045142,GO:0045739,GO:0045740,GO:0045944,GO:0046833,GO:0046872,GO:0047429,GO:0048146,GO:0048511,GO:0050434,GO:0050684,GO:0050691,GO:0050729,GO:0051028,GO:0051092,GO:0060760,GO:0061676,GO:0070063,GO:0070269,GO:0070578,GO:0070922,GO:0070934,GO:0070937,GO:0071356,GO:0071360,GO:0097165,GO:1903608,GO:1904973,GO:1905172,GO:1905538,GO:1905698,GO:1990518,GO:1990825,GO:1990841,GO:1990904,GO:2000373,GO:2000637,GO:2000765,GO:2000767" "alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II complex binding|regulatory region RNA binding|RNA polymerase II transcription factor binding|osteoblast differentiation|DNA binding|DNA helicase activity|DNA replication origin binding|double-stranded DNA binding|single-stranded DNA binding|transcription coregulator activity|transcription coactivator activity|RNA binding|RNA helicase activity|double-stranded RNA binding|single-stranded RNA binding|mRNA binding|protein binding|ATP binding|intracellular anatomical structure|nucleus|nucleoplasm|perichromatin fibrils|nucleolus|cytoplasm|centrosome|cytosol|polysome|DNA replication|DNA-templated transcription, termination|regulation of transcription by RNA polymerase II|inflammatory response|RNA secondary structure unwinding|actin cytoskeleton|membrane|RISC complex|nuclear body|ATPase activity|nucleoside-triphosphatase activity|targeting of mRNA for destruction involved in RNA interference|chromatin DNA binding|positive regulation of type I interferon production|DNA duplex unwinding|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|protein-containing complex|3'-5' DNA/RNA helicase activity|3'-5' RNA helicase activity|cellular protein-containing complex assembly|siRNA binding|RNA stem-loop binding|cytoplasmic ribonucleoprotein granule|DNA-templated viral transcription|polysomal ribosome|3'-5' DNA helicase activity|G-quadruplex DNA unwinding|innate immune response|positive regulation of innate immune response|triplex DNA binding|positive regulation of DNA repair|positive regulation of DNA replication|positive regulation of transcription by RNA polymerase II|positive regulation of RNA export from nucleus|metal ion binding|nucleoside-triphosphate diphosphatase activity|positive regulation of fibroblast proliferation|rhythmic process|positive regulation of viral transcription|regulation of mRNA processing|regulation of defense response to virus by host|positive regulation of inflammatory response|mRNA transport|positive regulation of NF-kappaB transcription factor activity|positive regulation of response to cytokine stimulus|importin-alpha family protein binding|RNA polymerase binding|pyroptosis|RISC-loading complex|small RNA loading onto RISC|CRD-mediated mRNA stabilization|CRD-mediated mRNA stability complex|cellular response to tumor necrosis factor|cellular response to exogenous dsRNA|nuclear stress granule|protein localization to cytoplasmic stress granule|positive regulation of viral translation|RISC complex binding|polysome binding|positive regulation of polysome binding|single-stranded 3'-5' DNA helicase activity|sequence-specific mRNA binding|promoter-specific chromatin binding|ribonucleoprotein complex|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity|positive regulation of gene silencing by miRNA|regulation of cytoplasmic translation|positive regulation of cytoplasmic translation" DIABLO 1180.178899 1094.515405 1265.842394 1.156532278 0.209805531 0.387541587 1 21.59418688 24.55646181 56616 diablo IAP-binding mitochondrial protein "GO:0005515,GO:0005739,GO:0005758,GO:0005829,GO:0006915,GO:0006919,GO:0008625,GO:0008631,GO:0008635,GO:0009898,GO:0035631,GO:0043065,GO:0051402,GO:0097193" protein binding|mitochondrion|mitochondrial intermembrane space|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to oxidative stress|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|cytoplasmic side of plasma membrane|CD40 receptor complex|positive regulation of apoptotic process|neuron apoptotic process|intrinsic apoptotic signaling pathway "hsa04210,hsa04215" Apoptosis|Apoptosis - multiple species DIAPH1 5887.086068 5551.648478 6222.523659 1.120842518 0.164583589 0.496441275 1 44.05669528 48.55429952 1729 diaphanous related formin 1 "GO:0003723,GO:0003779,GO:0005102,GO:0005515,GO:0005634,GO:0005737,GO:0005815,GO:0005829,GO:0005886,GO:0007010,GO:0007605,GO:0008360,GO:0030036,GO:0030041,GO:0030667,GO:0032587,GO:0032886,GO:0035372,GO:0043312,GO:0044325,GO:0051279,GO:0051493,GO:0071420,GO:0072686,GO:0101003,GO:2000145" RNA binding|actin binding|signaling receptor binding|protein binding|nucleus|cytoplasm|microtubule organizing center|cytosol|plasma membrane|cytoskeleton organization|sensory perception of sound|regulation of cell shape|actin cytoskeleton organization|actin filament polymerization|secretory granule membrane|ruffle membrane|regulation of microtubule-based process|protein localization to microtubule|neutrophil degranulation|ion channel binding|regulation of release of sequestered calcium ion into cytosol|regulation of cytoskeleton organization|cellular response to histamine|mitotic spindle|ficolin-1-rich granule membrane|regulation of cell motility "hsa04510,hsa04810,hsa04933,hsa05131" Focal adhesion|Regulation of actin cytoskeleton|AGE-RAGE signaling pathway in diabetic complications|Shigellosis DIAPH2 830.0476021 771.9871009 888.1081033 1.15041832 0.202158555 0.421010429 1 4.40825302 4.986473107 1730 diaphanous related formin 2 "GO:0003779,GO:0005102,GO:0005730,GO:0005769,GO:0005783,GO:0005829,GO:0007015,GO:0007275,GO:0007292,GO:0043231,GO:0048477" actin binding|signaling receptor binding|nucleolus|early endosome|endoplasmic reticulum|cytosol|actin filament organization|multicellular organism development|female gamete generation|intracellular membrane-bounded organelle|oogenesis hsa04810 Regulation of actin cytoskeleton DIAPH3 2153.230533 1886.270369 2420.190697 1.283056097 0.359584248 0.128403081 1 7.567224144 9.54670321 81624 diaphanous related formin 3 "GO:0003779,GO:0005634,GO:0005737,GO:0005829,GO:0007010,GO:0030036,GO:0030041,GO:0045296" actin binding|nucleus|cytoplasm|cytosol|cytoskeleton organization|actin cytoskeleton organization|actin filament polymerization|cadherin binding hsa04810 Regulation of actin cytoskeleton DICER1 1109.097404 1183.990998 1034.203809 0.873489587 -0.19513759 0.42404168 1 3.435406051 2.950577234 23405 "dicer 1, ribonuclease III" "GO:0000122,GO:0003677,GO:0003723,GO:0003725,GO:0004386,GO:0004521,GO:0004525,GO:0004530,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005793,GO:0005829,GO:0006309,GO:0010586,GO:0010626,GO:0010629,GO:0014040,GO:0016442,GO:0019904,GO:0021675,GO:0030422,GO:0030423,GO:0030425,GO:0030426,GO:0031054,GO:0031643,GO:0032290,GO:0032720,GO:0033167,GO:0033168,GO:0035087,GO:0035148,GO:0035196,GO:0035197,GO:0035280,GO:0036404,GO:0038061,GO:0046872,GO:0048471,GO:0048812,GO:0070062,GO:0070578,GO:0070883,GO:0090501,GO:0090502" "negative regulation of transcription by RNA polymerase II|DNA binding|RNA binding|double-stranded RNA binding|helicase activity|endoribonuclease activity|ribonuclease III activity|deoxyribonuclease I activity|protein binding|ATP binding|nucleus|cytoplasm|endoplasmic reticulum-Golgi intermediate compartment|cytosol|apoptotic DNA fragmentation|miRNA metabolic process|negative regulation of Schwann cell proliferation|negative regulation of gene expression|positive regulation of Schwann cell differentiation|RISC complex|protein domain specific binding|nerve development|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|dendrite|growth cone|pre-miRNA processing|positive regulation of myelination|peripheral nervous system myelin formation|negative regulation of tumor necrosis factor production|ARC complex|conversion of ds siRNA to ss siRNA involved in RNA interference|siRNA loading onto RISC involved in RNA interference|tube formation|production of miRNAs involved in gene silencing by miRNA|siRNA binding|miRNA loading onto RISC involved in gene silencing by miRNA|conversion of ds siRNA to ss siRNA|NIK/NF-kappaB signaling|metal ion binding|perinuclear region of cytoplasm|neuron projection morphogenesis|extracellular exosome|RISC-loading complex|pre-miRNA binding|RNA phosphodiester bond hydrolysis|RNA phosphodiester bond hydrolysis, endonucleolytic" hsa05206 MicroRNAs in cancer DIDO1 2343.605538 2417.921863 2269.289212 0.938528762 -0.091527137 0.699692739 1 9.546500399 8.809737334 11083 death inducer-obliterator 1 "GO:0003723,GO:0005634,GO:0005737,GO:0005819,GO:0006351,GO:0046872,GO:0097190" "RNA binding|nucleus|cytoplasm|spindle|transcription, DNA-templated|metal ion binding|apoptotic signaling pathway" DIMT1 597.7214619 589.9146715 605.5282523 1.026467524 0.037687984 0.892513734 1 9.835258294 9.926637484 27292 DIMT1 rRNA methyltransferase and ribosome maturation factor "GO:0000179,GO:0003723,GO:0005654,GO:0005730,GO:0005759,GO:0005829,GO:0031167,GO:0052909,GO:2000234" "rRNA (adenine-N6,N6-)-dimethyltransferase activity|RNA binding|nucleoplasm|nucleolus|mitochondrial matrix|cytosol|rRNA methylation|18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity|positive regulation of rRNA processing" DIO2 19.73326522 26.01034707 13.45618338 0.517339632 -0.950816378 0.27325094 1 0.207244613 0.10542174 1734 iodothyronine deiodinase 2 "GO:0001514,GO:0004800,GO:0005886,GO:0006590,GO:0008430,GO:0016020,GO:0016021,GO:0031625,GO:0033798,GO:0042403,GO:0042404,GO:0042446,GO:0050873,GO:0055114,GO:0120162" selenocysteine incorporation|thyroxine 5'-deiodinase activity|plasma membrane|thyroid hormone generation|selenium binding|membrane|integral component of membrane|ubiquitin protein ligase binding|thyroxine 5-deiodinase activity|thyroid hormone metabolic process|thyroid hormone catabolic process|hormone biosynthetic process|brown fat cell differentiation|oxidation-reduction process|positive regulation of cold-induced thermogenesis hsa04919 Thyroid hormone signaling pathway DIP2A 1074.763745 1115.323682 1034.203809 0.927267864 -0.108941938 0.65791566 1 7.855717968 7.162461008 23181 disco interacting protein 2 homolog A "GO:0003987,GO:0005515,GO:0005634,GO:0005739,GO:0006085,GO:0009986,GO:0010629,GO:0016020,GO:0043197,GO:0060997,GO:2000758" acetate-CoA ligase activity|protein binding|nucleus|mitochondrion|acetyl-CoA biosynthetic process|cell surface|negative regulation of gene expression|membrane|dendritic spine|dendritic spine morphogenesis|positive regulation of peptidyl-lysine acetylation DIP2B 1910.13672 1989.271344 1831.002096 0.920438583 -0.119606636 0.614546994 1 12.19572148 11.03757052 57609 disco interacting protein 2 homolog B "GO:0003674,GO:0005634,GO:0005737,GO:0008150,GO:0016020,GO:0030424,GO:0030425,GO:0030517,GO:0043014,GO:0043204,GO:0070062,GO:2000758" molecular_function|nucleus|cytoplasm|biological_process|membrane|axon|dendrite|negative regulation of axon extension|alpha-tubulin binding|perikaryon|extracellular exosome|positive regulation of peptidyl-lysine acetylation DIP2C 498.8123315 466.1054194 531.5192437 1.140341265 0.189465638 0.49125461 1 2.460453963 2.758806639 22982 disco interacting protein 2 homolog C "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process DIPK1A 510.0681859 559.7426689 460.3937029 0.822509572 -0.281895627 0.300875693 1 9.85238703 7.968078483 388650 divergent protein kinase domain 1A "GO:0005789,GO:0016021" endoplasmic reticulum membrane|integral component of membrane DIPK2A 274.576759 281.9521622 267.2013558 0.947683301 -0.077523079 0.821358163 1 3.110868036 2.898784932 205428 divergent protein kinase domain 2A "GO:0000139,GO:0005615,GO:0014066,GO:0030126,GO:0034392,GO:0060038,GO:1900020" Golgi membrane|extracellular space|regulation of phosphatidylinositol 3-kinase signaling|COPI vesicle coat|negative regulation of smooth muscle cell apoptotic process|cardiac muscle cell proliferation|positive regulation of protein kinase C activity DIRAS3 2.962725795 2.080827765 3.844623824 1.847641543 0.88568489 0.829811711 1 0.074983088 0.136223558 9077 DIRAS family GTPase 3 "GO:0000079,GO:0003924,GO:0005515,GO:0005525,GO:0005886,GO:0006349,GO:0007264,GO:0019003" regulation of cyclin-dependent protein serine/threonine kinase activity|GTPase activity|protein binding|GTP binding|plasma membrane|regulation of gene expression by genetic imprinting|small GTPase mediated signal transduction|GDP binding DIS3 2596.217176 2249.374814 2943.059537 1.308390011 0.38779265 0.101102974 1 11.28348526 14.51615725 22894 "DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease" "GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0003723,GO:0004519,GO:0005085,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006364,GO:0016020,GO:0016075,GO:0043488,GO:0043928,GO:0050790,GO:0071034,GO:0090503" "3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|RNA binding|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|nucleoplasm|nucleolus|cytosol|rRNA processing|membrane|rRNA catabolic process|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|regulation of catalytic activity|CUT catabolic process|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation DIS3L 385.891598 428.6505196 343.1326763 0.800495183 -0.321035373 0.272392749 1 4.02964425 3.171732911 115752 DIS3 like exosome 3'-5' exoribonuclease "GO:0000175,GO:0000177,GO:0000178,GO:0003723,GO:0005515,GO:0005813,GO:0005829,GO:0005886,GO:0016075,GO:0019899,GO:0090503" "3'-5'-exoribonuclease activity|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|RNA binding|protein binding|centrosome|cytosol|plasma membrane|rRNA catabolic process|enzyme binding|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation DIS3L2 534.5040496 444.2567279 624.7513714 1.406284547 0.491888538 0.067728882 1 5.223433588 7.222714703 129563 DIS3 like 3'-5' exoribonuclease 2 "GO:0000175,GO:0000178,GO:0000278,GO:0000287,GO:0000291,GO:0000932,GO:0004540,GO:0005515,GO:0005737,GO:0005844,GO:0006402,GO:0008266,GO:0008285,GO:0010587,GO:0019827,GO:0034427,GO:0051301,GO:0051306,GO:0090503,GO:1990074" "3'-5'-exoribonuclease activity|exosome (RNase complex)|mitotic cell cycle|magnesium ion binding|nuclear-transcribed mRNA catabolic process, exonucleolytic|P-body|ribonuclease activity|protein binding|cytoplasm|polysome|mRNA catabolic process|poly(U) RNA binding|negative regulation of cell population proliferation|miRNA catabolic process|stem cell population maintenance|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|cell division|mitotic sister chromatid separation|RNA phosphodiester bond hydrolysis, exonucleolytic|polyuridylation-dependent mRNA catabolic process" DISC1 275.5574222 332.9324424 218.182402 0.65533536 -0.609694718 0.059929143 1 1.323106155 0.852568868 27185 DISC1 scaffold protein "GO:0000226,GO:0001764,GO:0001954,GO:0002052,GO:0005515,GO:0005634,GO:0005739,GO:0005783,GO:0005813,GO:0005829,GO:0005871,GO:0005874,GO:0008021,GO:0010975,GO:0010976,GO:0014069,GO:0019894,GO:0021846,GO:0021852,GO:0030177,GO:0030286,GO:0031929,GO:0032091,GO:0036064,GO:0044297,GO:0044877,GO:0045111,GO:0045773,GO:0048471,GO:0051560,GO:0051602,GO:0051966,GO:0060070,GO:0060090,GO:0060271,GO:0060998,GO:0071539,GO:0090128,GO:0090724,GO:0097546,GO:1905515,GO:2000060" "microtubule cytoskeleton organization|neuron migration|positive regulation of cell-matrix adhesion|positive regulation of neuroblast proliferation|protein binding|nucleus|mitochondrion|endoplasmic reticulum|centrosome|cytosol|kinesin complex|microtubule|synaptic vesicle|regulation of neuron projection development|positive regulation of neuron projection development|postsynaptic density|kinesin binding|cell proliferation in forebrain|pyramidal neuron migration|positive regulation of Wnt signaling pathway|dynein complex|TOR signaling|negative regulation of protein binding|ciliary basal body|cell body|protein-containing complex binding|intermediate filament cytoskeleton|positive regulation of axon extension|perinuclear region of cytoplasm|mitochondrial calcium ion homeostasis|response to electrical stimulus|regulation of synaptic transmission, glutamatergic|canonical Wnt signaling pathway|molecular adaptor activity|cilium assembly|regulation of dendritic spine development|protein localization to centrosome|regulation of synapse maturation|central region of growth cone|ciliary base|non-motile cilium assembly|positive regulation of ubiquitin-dependent protein catabolic process" DISP1 83.86275799 94.67766332 73.04785266 0.771542623 -0.374182237 0.459823482 1 0.708365748 0.537388855 84976 dispatched RND transporter family member 1 "GO:0005515,GO:0015833,GO:0016021,GO:0016323,GO:0050708,GO:0060539,GO:0070207,GO:0098656,GO:1904680" protein binding|peptide transport|integral component of membrane|basolateral plasma membrane|regulation of protein secretion|diaphragm development|protein homotrimerization|anion transmembrane transport|peptide transmembrane transporter activity DISP2 19.49549145 19.76786377 19.22311912 0.972442918 -0.040314528 1 1 0.07144136 0.068310114 85455 dispatched RND transporter family member 2 "GO:0003674,GO:0005575,GO:0005886,GO:0007224,GO:0016021" molecular_function|cellular_component|plasma membrane|smoothened signaling pathway|integral component of membrane DISP3 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.02241622 0.006787347 57540 dispatched RND transporter family member 3 "GO:0003674,GO:0005737,GO:0005783,GO:0005789,GO:0007224,GO:0008203,GO:0016021,GO:0030154,GO:0030659,GO:0031965,GO:0032368,GO:0042632,GO:0045665,GO:0045834,GO:2000179" molecular_function|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|smoothened signaling pathway|cholesterol metabolic process|integral component of membrane|cell differentiation|cytoplasmic vesicle membrane|nuclear membrane|regulation of lipid transport|cholesterol homeostasis|negative regulation of neuron differentiation|positive regulation of lipid metabolic process|positive regulation of neural precursor cell proliferation DIXDC1 443.4420684 425.529278 461.3548589 1.084190637 0.116618453 0.68411585 1 3.192705677 3.403578059 85458 DIX domain containing 1 "GO:0003779,GO:0005515,GO:0005829,GO:0005856,GO:0005925,GO:0019904,GO:0021799,GO:0021869,GO:0030177,GO:0032956,GO:0043015,GO:0045665,GO:0060070,GO:0070507" actin binding|protein binding|cytosol|cytoskeleton|focal adhesion|protein domain specific binding|cerebral cortex radially oriented cell migration|forebrain ventricular zone progenitor cell division|positive regulation of Wnt signaling pathway|regulation of actin cytoskeleton organization|gamma-tubulin binding|negative regulation of neuron differentiation|canonical Wnt signaling pathway|regulation of microtubule cytoskeleton organization DKC1 2616.86448 2690.510301 2543.21866 0.945255128 -0.081224323 0.732262282 1 58.51165028 54.3829257 1736 dyskerin pseudouridine synthase 1 "GO:0000455,GO:0000495,GO:0001650,GO:0003720,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005697,GO:0005730,GO:0005737,GO:0006364,GO:0006396,GO:0007004,GO:0009982,GO:0031118,GO:0031120,GO:0031429,GO:0032212,GO:0034513,GO:0051973,GO:0070034,GO:0072589,GO:0090661,GO:0090666,GO:0090669,GO:1904851,GO:1904871,GO:1904872,GO:1904874,GO:1990481" enzyme-directed rRNA pseudouridine synthesis|box H/ACA RNA 3'-end processing|fibrillar center|telomerase activity|RNA binding|protein binding|nucleus|nucleoplasm|telomerase holoenzyme complex|nucleolus|cytoplasm|rRNA processing|RNA processing|telomere maintenance via telomerase|pseudouridine synthase activity|rRNA pseudouridine synthesis|snRNA pseudouridine synthesis|box H/ACA snoRNP complex|positive regulation of telomere maintenance via telomerase|box H/ACA snoRNA binding|positive regulation of telomerase activity|telomerase RNA binding|box H/ACA scaRNP complex|box H/ACA telomerase RNP complex|scaRNA localization to Cajal body|telomerase RNA stabilization|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|regulation of telomerase RNA localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body|mRNA pseudouridine synthesis hsa03008 Ribosome biogenesis in eukaryotes DKK1 3319.662598 2708.197337 3931.12786 1.451566253 0.537610422 0.02360144 0.846928903 80.07286116 114.2860936 22943 dickkopf WNT signaling pathway inhibitor 1 "GO:0000122,GO:0002090,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0007611,GO:0008083,GO:0010628,GO:0010942,GO:0016055,GO:0030178,GO:0030279,GO:0031901,GO:0032091,GO:0033137,GO:0039706,GO:0042662,GO:0042663,GO:0043066,GO:0043507,GO:0045813,GO:0048019,GO:0050750,GO:0060173,GO:0060394,GO:0090082,GO:0090090,GO:0090647,GO:0098883,GO:1901216,GO:1901296,GO:1902949,GO:1904338,GO:1904723,GO:2000096,GO:2000272,GO:2000726" "negative regulation of transcription by RNA polymerase II|regulation of receptor internalization|protein binding|extracellular region|extracellular space|plasma membrane|learning or memory|growth factor activity|positive regulation of gene expression|positive regulation of cell death|Wnt signaling pathway|negative regulation of Wnt signaling pathway|negative regulation of ossification|early endosome membrane|negative regulation of protein binding|negative regulation of peptidyl-serine phosphorylation|co-receptor binding|negative regulation of mesodermal cell fate specification|regulation of endodermal cell fate specification|negative regulation of apoptotic process|positive regulation of JUN kinase activity|positive regulation of Wnt signaling pathway, calcium modulating pathway|receptor antagonist activity|low-density lipoprotein particle receptor binding|limb development|negative regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|modulation of age-related behavioral decline|synapse pruning|positive regulation of neuron death|negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment|positive regulation of tau-protein kinase activity|regulation of dopaminergic neuron differentiation|negative regulation of Wnt-Frizzled-LRP5/6 complex assembly|positive regulation of Wnt signaling pathway, planar cell polarity pathway|negative regulation of signaling receptor activity|negative regulation of cardiac muscle cell differentiation" "hsa04310,hsa05010,hsa05022" Wnt signaling pathway|Alzheimer disease|Pathways of neurodegeneration - multiple diseases DKK3 9443.753598 8955.882702 9931.624493 1.108949818 0.149194083 0.550777207 1 143.833584 156.8351396 27122 dickkopf WNT signaling pathway inhibitor 3 "GO:0005515,GO:0005615,GO:0009653,GO:0016055,GO:0017015,GO:0030325,GO:0032348,GO:0039706,GO:0045892,GO:0048019,GO:0090090,GO:1902613,GO:2000065,GO:2000272" "protein binding|extracellular space|anatomical structure morphogenesis|Wnt signaling pathway|regulation of transforming growth factor beta receptor signaling pathway|adrenal gland development|negative regulation of aldosterone biosynthetic process|co-receptor binding|negative regulation of transcription, DNA-templated|receptor antagonist activity|negative regulation of canonical Wnt signaling pathway|negative regulation of anti-Mullerian hormone signaling pathway|negative regulation of cortisol biosynthetic process|negative regulation of signaling receptor activity" DKKL1 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.037952821 0.103424687 27120 dickkopf like acrosomal protein 1 "GO:0001669,GO:0005615,GO:0007341,GO:0009653,GO:0039706,GO:0043065,GO:0045600,GO:0048019,GO:0090090,GO:2000225,GO:2000272" acrosomal vesicle|extracellular space|penetration of zona pellucida|anatomical structure morphogenesis|co-receptor binding|positive regulation of apoptotic process|positive regulation of fat cell differentiation|receptor antagonist activity|negative regulation of canonical Wnt signaling pathway|negative regulation of testosterone biosynthetic process|negative regulation of signaling receptor activity DLAT 1332.466169 1332.770184 1332.162155 0.999543786 -0.000658328 1 1 18.87171536 18.54745728 1737 dihydrolipoamide S-acetyltransferase "GO:0004742,GO:0005515,GO:0005739,GO:0005759,GO:0005967,GO:0006006,GO:0006086,GO:0006090,GO:0006099,GO:0018215,GO:0030431,GO:0034604,GO:0042802,GO:0043231,GO:0045254" dihydrolipoyllysine-residue acetyltransferase activity|protein binding|mitochondrion|mitochondrial matrix|mitochondrial pyruvate dehydrogenase complex|glucose metabolic process|acetyl-CoA biosynthetic process from pyruvate|pyruvate metabolic process|tricarboxylic acid cycle|protein phosphopantetheinylation|sleep|pyruvate dehydrogenase (NAD+) activity|identical protein binding|intracellular membrane-bounded organelle|pyruvate dehydrogenase complex "hsa00010,hsa00020,hsa00620" Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Pyruvate metabolism DLC1 3748.084176 3736.126253 3760.0421 1.006401242 0.009205607 0.970349006 1 21.77224191 21.54495015 10395 DLC1 Rho GTPase activating protein "GO:0001843,GO:0003007,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005901,GO:0005925,GO:0006915,GO:0006919,GO:0007165,GO:0008285,GO:0008289,GO:0008360,GO:0021575,GO:0030036,GO:0030336,GO:0030864,GO:0030900,GO:0032587,GO:0032956,GO:0035023,GO:0035024,GO:0035307,GO:0042169,GO:0043547,GO:0045121,GO:0048041,GO:0051056,GO:0051497,GO:0051895,GO:1900119" neural tube closure|heart morphogenesis|GTPase activator activity|protein binding|nucleus|cytoplasm|cytosol|caveola|focal adhesion|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|negative regulation of cell population proliferation|lipid binding|regulation of cell shape|hindbrain morphogenesis|actin cytoskeleton organization|negative regulation of cell migration|cortical actin cytoskeleton|forebrain development|ruffle membrane|regulation of actin cytoskeleton organization|regulation of Rho protein signal transduction|negative regulation of Rho protein signal transduction|positive regulation of protein dephosphorylation|SH2 domain binding|positive regulation of GTPase activity|membrane raft|focal adhesion assembly|regulation of small GTPase mediated signal transduction|negative regulation of stress fiber assembly|negative regulation of focal adhesion assembly|positive regulation of execution phase of apoptosis DLD 1708.171895 1695.874629 1720.469161 1.014502565 0.020772513 0.932875166 1 25.05001717 24.98804941 1738 dihydrolipoamide dehydrogenase "GO:0004148,GO:0005515,GO:0005634,GO:0005739,GO:0005759,GO:0006090,GO:0006099,GO:0006103,GO:0006120,GO:0006508,GO:0006554,GO:0007369,GO:0007568,GO:0009083,GO:0009106,GO:0031514,GO:0034604,GO:0042391,GO:0043159,GO:0043544,GO:0045252,GO:0045254,GO:0045454,GO:0048240,GO:0050660,GO:0051068,GO:0051287,GO:0055114,GO:0061732,GO:0106077" "dihydrolipoyl dehydrogenase activity|protein binding|nucleus|mitochondrion|mitochondrial matrix|pyruvate metabolic process|tricarboxylic acid cycle|2-oxoglutarate metabolic process|mitochondrial electron transport, NADH to ubiquinone|proteolysis|lysine catabolic process|gastrulation|aging|branched-chain amino acid catabolic process|lipoate metabolic process|motile cilium|pyruvate dehydrogenase (NAD+) activity|regulation of membrane potential|acrosomal matrix|lipoamide binding|oxoglutarate dehydrogenase complex|pyruvate dehydrogenase complex|cell redox homeostasis|sperm capacitation|flavin adenine dinucleotide binding|dihydrolipoamide metabolic process|NAD binding|oxidation-reduction process|mitochondrial acetyl-CoA biosynthetic process from pyruvate|histone succinylation" "hsa00010,hsa00020,hsa00260,hsa00280,hsa00310,hsa00380,hsa00620,hsa00630,hsa00640" "Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Glycine, serine and threonine metabolism|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism" DLG1 3335.042438 3301.23325 3368.851626 1.020482762 0.029251813 0.903058422 1 19.51492591 19.58140088 1739 discs large MAGUK scaffold protein 1 "GO:0000122,GO:0000165,GO:0001658,GO:0001771,GO:0001772,GO:0001935,GO:0002088,GO:0004385,GO:0004721,GO:0005515,GO:0005604,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005874,GO:0005886,GO:0005911,GO:0005923,GO:0006470,GO:0007015,GO:0007163,GO:0007268,GO:0008022,GO:0008092,GO:0008284,GO:0008328,GO:0008360,GO:0009790,GO:0009898,GO:0014704,GO:0015459,GO:0016032,GO:0016323,GO:0016324,GO:0016328,GO:0019901,GO:0019902,GO:0030054,GO:0030432,GO:0030838,GO:0030866,GO:0030953,GO:0031253,GO:0031434,GO:0031579,GO:0031594,GO:0031641,GO:0032147,GO:0033268,GO:0034629,GO:0035748,GO:0042110,GO:0042130,GO:0042383,GO:0042391,GO:0042982,GO:0043005,GO:0043113,GO:0043219,GO:0043268,GO:0043622,GO:0044325,GO:0045121,GO:0045197,GO:0045296,GO:0046037,GO:0046710,GO:0048471,GO:0048608,GO:0048704,GO:0048745,GO:0050680,GO:0051660,GO:0051898,GO:0060022,GO:0060090,GO:0070062,GO:0070373,GO:0070830,GO:0072659,GO:0097016,GO:0097025,GO:0097060,GO:0097120,GO:0098609,GO:0098839,GO:0098911,GO:0098919,GO:0098978,GO:0099562,GO:0099645,GO:1901222,GO:1902305,GO:1902473,GO:1903078,GO:1903286,GO:1903753,GO:1903760,GO:1903764,GO:2000134,GO:2000310" negative regulation of transcription by RNA polymerase II|MAPK cascade|branching involved in ureteric bud morphogenesis|immunological synapse formation|immunological synapse|endothelial cell proliferation|lens development in camera-type eye|guanylate kinase activity|phosphoprotein phosphatase activity|protein binding|basement membrane|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|microtubule|plasma membrane|cell-cell junction|bicellular tight junction|protein dephosphorylation|actin filament organization|establishment or maintenance of cell polarity|chemical synaptic transmission|protein C-terminus binding|cytoskeletal protein binding|positive regulation of cell population proliferation|ionotropic glutamate receptor complex|regulation of cell shape|embryo development|cytoplasmic side of plasma membrane|intercalated disc|potassium channel regulator activity|viral process|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|protein kinase binding|phosphatase binding|cell junction|peristalsis|positive regulation of actin filament polymerization|cortical actin cytoskeleton organization|astral microtubule organization|cell projection membrane|mitogen-activated protein kinase kinase binding|membrane raft organization|neuromuscular junction|regulation of myelination|activation of protein kinase activity|node of Ranvier|cellular protein-containing complex localization|myelin sheath abaxonal region|T cell activation|negative regulation of T cell proliferation|sarcolemma|regulation of membrane potential|amyloid precursor protein metabolic process|neuron projection|receptor clustering|lateral loop|positive regulation of potassium ion transport|cortical microtubule organization|ion channel binding|membrane raft|establishment or maintenance of epithelial cell apical/basal polarity|cadherin binding|GMP metabolic process|GDP metabolic process|perinuclear region of cytoplasm|reproductive structure development|embryonic skeletal system morphogenesis|smooth muscle tissue development|negative regulation of epithelial cell proliferation|establishment of centrosome localization|negative regulation of protein kinase B signaling|hard palate development|molecular adaptor activity|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|bicellular tight junction assembly|protein localization to plasma membrane|L27 domain binding|MPP7-DLG1-LIN7 complex|synaptic membrane|receptor localization to synapse|cell-cell adhesion|postsynaptic density membrane|regulation of ventricular cardiac muscle cell action potential|structural constituent of postsynaptic density|glutamatergic synapse|maintenance of postsynaptic density structure|neurotransmitter receptor localization to postsynaptic specialization membrane|regulation of NIK/NF-kappaB signaling|regulation of sodium ion transmembrane transport|regulation of protein localization to synapse|positive regulation of protein localization to plasma membrane|regulation of potassium ion import|negative regulation of p38MAPK cascade|regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|regulation of potassium ion export across plasma membrane|negative regulation of G1/S transition of mitotic cell cycle|regulation of NMDA receptor activity "hsa04390,hsa04530,hsa04660,hsa05165,hsa05166,hsa05203" Hippo signaling pathway|Tight junction|T cell receptor signaling pathway|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis DLG2 53.56180767 56.18234966 50.94126567 0.90671298 -0.141282158 0.838016874 1 0.157179112 0.140131523 1740 discs large MAGUK scaffold protein 2 "GO:0000165,GO:0004385,GO:0005515,GO:0005829,GO:0005886,GO:0007268,GO:0008076,GO:0008328,GO:0009790,GO:0010923,GO:0014069,GO:0016020,GO:0016323,GO:0019900,GO:0030054,GO:0031594,GO:0035865,GO:0043005,GO:0043113,GO:0043204,GO:0044224,GO:0045197,GO:0046037,GO:0046710,GO:0097120,GO:0098609,GO:0098839,GO:0099641,GO:0099642,GO:1904115,GO:2000310" MAPK cascade|guanylate kinase activity|protein binding|cytosol|plasma membrane|chemical synaptic transmission|voltage-gated potassium channel complex|ionotropic glutamate receptor complex|embryo development|negative regulation of phosphatase activity|postsynaptic density|membrane|basolateral plasma membrane|kinase binding|cell junction|neuromuscular junction|cellular response to potassium ion|neuron projection|receptor clustering|perikaryon|juxtaparanode region of axon|establishment or maintenance of epithelial cell apical/basal polarity|GMP metabolic process|GDP metabolic process|receptor localization to synapse|cell-cell adhesion|postsynaptic density membrane|anterograde axonal protein transport|retrograde axonal protein transport|axon cytoplasm|regulation of NMDA receptor activity "hsa04390,hsa04530,hsa05165" Hippo signaling pathway|Tight junction|Human papillomavirus infection DLG3 1390.928106 1353.578461 1428.277751 1.055186523 0.077498044 0.748622471 1 8.091173242 8.394830167 1741 discs large MAGUK scaffold protein 3 "GO:0000165,GO:0005515,GO:0005615,GO:0005829,GO:0005886,GO:0008285,GO:0008328,GO:0009790,GO:0010923,GO:0016323,GO:0019900,GO:0019902,GO:0030054,GO:0043113,GO:0045197,GO:0061098,GO:0097120,GO:0098609,GO:2000310" MAPK cascade|protein binding|extracellular space|cytosol|plasma membrane|negative regulation of cell population proliferation|ionotropic glutamate receptor complex|embryo development|negative regulation of phosphatase activity|basolateral plasma membrane|kinase binding|phosphatase binding|cell junction|receptor clustering|establishment or maintenance of epithelial cell apical/basal polarity|positive regulation of protein tyrosine kinase activity|receptor localization to synapse|cell-cell adhesion|regulation of NMDA receptor activity "hsa04390,hsa04530,hsa05165" Hippo signaling pathway|Tight junction|Human papillomavirus infection DLG4 1029.080498 887.4730419 1170.687954 1.319125088 0.399581377 0.103227123 1 6.514828767 8.450067226 1742 discs large MAGUK scaffold protein 4 "GO:0000165,GO:0002091,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0007165,GO:0007204,GO:0007268,GO:0007399,GO:0007612,GO:0008021,GO:0008022,GO:0008076,GO:0008328,GO:0014069,GO:0016188,GO:0019900,GO:0019903,GO:0030054,GO:0030165,GO:0030666,GO:0030863,GO:0031234,GO:0031594,GO:0031697,GO:0031748,GO:0031812,GO:0032281,GO:0032839,GO:0033130,GO:0035176,GO:0035255,GO:0035418,GO:0035641,GO:0035865,GO:0043005,GO:0043113,GO:0043197,GO:0044224,GO:0044300,GO:0044306,GO:0044309,GO:0044877,GO:0045184,GO:0045202,GO:0045211,GO:0048169,GO:0050806,GO:0050885,GO:0060076,GO:0060997,GO:0061098,GO:0065003,GO:0071625,GO:0097060,GO:0097109,GO:0097110,GO:0097113,GO:0097120,GO:0098609,GO:0098839,GO:0098970,GO:0098978,GO:0150012,GO:2000310,GO:2000463,GO:2000821" MAPK cascade|negative regulation of receptor internalization|protein binding|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|signal transduction|positive regulation of cytosolic calcium ion concentration|chemical synaptic transmission|nervous system development|learning|synaptic vesicle|protein C-terminus binding|voltage-gated potassium channel complex|ionotropic glutamate receptor complex|postsynaptic density|synaptic vesicle maturation|kinase binding|protein phosphatase binding|cell junction|PDZ domain binding|endocytic vesicle membrane|cortical cytoskeleton|extrinsic component of cytoplasmic side of plasma membrane|neuromuscular junction|beta-1 adrenergic receptor binding|D1 dopamine receptor binding|P2Y1 nucleotide receptor binding|AMPA glutamate receptor complex|dendrite cytoplasm|acetylcholine receptor binding|social behavior|ionotropic glutamate receptor binding|protein localization to synapse|locomotory exploration behavior|cellular response to potassium ion|neuron projection|receptor clustering|dendritic spine|juxtaparanode region of axon|cerebellar mossy fiber|neuron projection terminus|neuron spine|protein-containing complex binding|establishment of protein localization|synapse|postsynaptic membrane|regulation of long-term neuronal synaptic plasticity|positive regulation of synaptic transmission|neuromuscular process controlling balance|excitatory synapse|dendritic spine morphogenesis|positive regulation of protein tyrosine kinase activity|protein-containing complex assembly|vocalization behavior|synaptic membrane|neuroligin family protein binding|scaffold protein binding|AMPA glutamate receptor clustering|receptor localization to synapse|cell-cell adhesion|postsynaptic density membrane|postsynaptic neurotransmitter receptor diffusion trapping|glutamatergic synapse|positive regulation of neuron projection arborization|regulation of NMDA receptor activity|positive regulation of excitatory postsynaptic potential|regulation of grooming behavior "hsa04390,hsa04724,hsa05016,hsa05022,hsa05030" Hippo signaling pathway|Glutamatergic synapse|Huntington disease|Pathways of neurodegeneration - multiple diseases|Cocaine addiction DLG5 3405.062169 3461.456988 3348.667351 0.96741556 -0.047792352 0.841378636 1 18.23249087 17.34324071 9231 discs large MAGUK scaffold protein 5 "GO:0001837,GO:0005515,GO:0005737,GO:0005886,GO:0005912,GO:0007165,GO:0008013,GO:0008092,GO:0008285,GO:0014069,GO:0030011,GO:0030054,GO:0030159,GO:0030336,GO:0030859,GO:0030901,GO:0035331,GO:0035332,GO:0035556,GO:0036064,GO:0042130,GO:0042981,GO:0045176,GO:0045186,GO:0045197,GO:0045880,GO:0051965,GO:0060441,GO:0060999,GO:0065003,GO:0071896,GO:0072205,GO:0098609" epithelial to mesenchymal transition|protein binding|cytoplasm|plasma membrane|adherens junction|signal transduction|beta-catenin binding|cytoskeletal protein binding|negative regulation of cell population proliferation|postsynaptic density|maintenance of cell polarity|cell junction|signaling receptor complex adaptor activity|negative regulation of cell migration|polarized epithelial cell differentiation|midbrain development|negative regulation of hippo signaling|positive regulation of hippo signaling|intracellular signal transduction|ciliary basal body|negative regulation of T cell proliferation|regulation of apoptotic process|apical protein localization|zonula adherens assembly|establishment or maintenance of epithelial cell apical/basal polarity|positive regulation of smoothened signaling pathway|positive regulation of synapse assembly|epithelial tube branching involved in lung morphogenesis|positive regulation of dendritic spine development|protein-containing complex assembly|protein localization to adherens junction|metanephric collecting duct development|cell-cell adhesion hsa04390 Hippo signaling pathway DLGAP4 1827.81569 1745.814495 1909.816885 1.09394033 0.129534047 0.585748136 1 15.02029839 16.15635445 22839 DLG associated protein 4 "GO:0005515,GO:0005886,GO:0023052,GO:0031594,GO:0060090,GO:0098962,GO:0098978,GO:0098981,GO:0099572" protein binding|plasma membrane|signaling|neuromuscular junction|molecular adaptor activity|regulation of postsynaptic neurotransmitter receptor activity|glutamatergic synapse|cholinergic synapse|postsynaptic specialization DLGAP5 2395.759596 2588.54974 2202.969451 0.851043894 -0.232694551 0.324996862 1 42.14342345 35.26573589 9787 DLG associated protein 5 "GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0007052,GO:0007059,GO:0007079,GO:0007221,GO:0007346,GO:0008017,GO:0031616,GO:0034451,GO:0045842,GO:0051382,GO:0051642" protein binding|nucleus|cytoplasm|mitochondrion|cytosol|mitotic spindle organization|chromosome segregation|mitotic chromosome movement towards spindle pole|positive regulation of transcription of Notch receptor target|regulation of mitotic cell cycle|microtubule binding|spindle pole centrosome|centriolar satellite|positive regulation of mitotic metaphase/anaphase transition|kinetochore assembly|centrosome localization DLK2 38.79283807 34.33365813 43.25201802 1.259755598 0.333143867 0.636557627 1 0.700697603 0.867936809 65989 delta like non-canonical Notch ligand 2 "GO:0005112,GO:0005509,GO:0016021,GO:0045598,GO:0045746" Notch binding|calcium ion binding|integral component of membrane|regulation of fat cell differentiation|negative regulation of Notch signaling pathway DLL1 40.43271682 39.53572754 41.32970611 1.045376136 0.064022131 0.963532058 1 0.557450229 0.572993715 28514 delta like canonical Notch ligand 1 "GO:0001709,GO:0001756,GO:0001757,GO:0001947,GO:0002315,GO:0003323,GO:0005112,GO:0005509,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0005912,GO:0007219,GO:0007368,GO:0007386,GO:0008217,GO:0008284,GO:0008285,GO:0009954,GO:0014002,GO:0014807,GO:0016324,GO:0021510,GO:0021688,GO:0021693,GO:0030097,GO:0030154,GO:0030155,GO:0030857,GO:0030957,GO:0031410,GO:0032693,GO:0034351,GO:0035265,GO:0040008,GO:0045121,GO:0045596,GO:0045605,GO:0045608,GO:0045638,GO:0045662,GO:0045665,GO:0045746,GO:0045747,GO:0045807,GO:0045944,GO:0046331,GO:0048630,GO:0048631,GO:0048633,GO:0048665,GO:0048839,GO:0050767,GO:0051302,GO:0060041,GO:0060042,GO:0060853,GO:0070986,GO:0072006,GO:0072014,GO:0072070,GO:0072583,GO:0097009,GO:0097102,GO:0097110,GO:0097150,GO:0098773,GO:1900746,GO:1903672,GO:2000726" cell fate determination|somitogenesis|somite specification|heart looping|marginal zone B cell differentiation|type B pancreatic cell development|Notch binding|calcium ion binding|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|adherens junction|Notch signaling pathway|determination of left/right symmetry|compartment pattern specification|regulation of blood pressure|positive regulation of cell population proliferation|negative regulation of cell population proliferation|proximal/distal pattern formation|astrocyte development|regulation of somitogenesis|apical plasma membrane|spinal cord development|cerebellar molecular layer formation|cerebellar Purkinje cell layer structural organization|hemopoiesis|cell differentiation|regulation of cell adhesion|negative regulation of epithelial cell differentiation|Tat protein binding|cytoplasmic vesicle|negative regulation of interleukin-10 production|negative regulation of glial cell apoptotic process|organ growth|regulation of growth|membrane raft|negative regulation of cell differentiation|negative regulation of epidermal cell differentiation|negative regulation of inner ear auditory receptor cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of myoblast differentiation|negative regulation of neuron differentiation|negative regulation of Notch signaling pathway|positive regulation of Notch signaling pathway|positive regulation of endocytosis|positive regulation of transcription by RNA polymerase II|lateral inhibition|skeletal muscle tissue growth|regulation of skeletal muscle tissue growth|positive regulation of skeletal muscle tissue growth|neuron fate specification|inner ear development|regulation of neurogenesis|regulation of cell division|retina development in camera-type eye|retina morphogenesis in camera-type eye|Notch signaling pathway involved in arterial endothelial cell fate commitment|left/right axis specification|nephron development|proximal tubule development|loop of Henle development|clathrin-dependent endocytosis|energy homeostasis|endothelial tip cell fate specification|scaffold protein binding|neuronal stem cell population maintenance|skin epidermis development|regulation of vascular endothelial growth factor signaling pathway|positive regulation of sprouting angiogenesis|negative regulation of cardiac muscle cell differentiation "hsa01522,hsa04330,hsa04658,hsa05200,hsa05224" Endocrine resistance|Notch signaling pathway|Th1 and Th2 cell differentiation|Pathways in cancer|Breast cancer DLL4 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.04862082 0.058887066 54567 delta like canonical Notch ligand 4 "GO:0000122,GO:0001525,GO:0001569,GO:0001974,GO:0003180,GO:0003208,GO:0003209,GO:0003222,GO:0003344,GO:0005112,GO:0005509,GO:0005515,GO:0005886,GO:0007165,GO:0007219,GO:0007601,GO:0008015,GO:0008285,GO:0010596,GO:0010628,GO:0010629,GO:0016021,GO:0030217,GO:0035912,GO:0035924,GO:0044344,GO:0045746,GO:0045747,GO:0050767,GO:0060579,GO:0061074,GO:0061314,GO:0072554,GO:0090051,GO:1903588,GO:2000179" negative regulation of transcription by RNA polymerase II|angiogenesis|branching involved in blood vessel morphogenesis|blood vessel remodeling|aortic valve morphogenesis|cardiac ventricle morphogenesis|cardiac atrium morphogenesis|ventricular trabecula myocardium morphogenesis|pericardium morphogenesis|Notch binding|calcium ion binding|protein binding|plasma membrane|signal transduction|Notch signaling pathway|visual perception|blood circulation|negative regulation of cell population proliferation|negative regulation of endothelial cell migration|positive regulation of gene expression|negative regulation of gene expression|integral component of membrane|T cell differentiation|dorsal aorta morphogenesis|cellular response to vascular endothelial growth factor stimulus|cellular response to fibroblast growth factor stimulus|negative regulation of Notch signaling pathway|positive regulation of Notch signaling pathway|regulation of neurogenesis|ventral spinal cord interneuron fate commitment|regulation of neural retina development|Notch signaling involved in heart development|blood vessel lumenization|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|positive regulation of neural precursor cell proliferation "hsa01522,hsa04330,hsa04658,hsa05200,hsa05224" Endocrine resistance|Notch signaling pathway|Th1 and Th2 cell differentiation|Pathways in cancer|Breast cancer DLST 3962.961054 3889.067093 4036.855015 1.038000867 0.053807649 0.822053693 1 56.03465523 57.1907246 1743 dihydrolipoamide S-succinyltransferase "GO:0004149,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0006091,GO:0006099,GO:0006103,GO:0006104,GO:0006554,GO:0016020,GO:0016746,GO:0018215,GO:0033512,GO:0034451,GO:0045252,GO:0106077" "dihydrolipoyllysine-residue succinyltransferase activity|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|generation of precursor metabolites and energy|tricarboxylic acid cycle|2-oxoglutarate metabolic process|succinyl-CoA metabolic process|lysine catabolic process|membrane|transferase activity, transferring acyl groups|protein phosphopantetheinylation|L-lysine catabolic process to acetyl-CoA via saccharopine|centriolar satellite|oxoglutarate dehydrogenase complex|histone succinylation" "hsa00020,hsa00310,hsa00380" Citrate cycle (TCA cycle)|Lysine degradation|Tryptophan metabolism DLX1 383.3849124 388.0743782 378.6954467 0.975832129 -0.035295111 0.913187518 1 8.790669064 8.434672458 1745 distal-less homeobox 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0003682,GO:0005515,GO:0005634,GO:0006357,GO:0009790,GO:0009954,GO:0021544,GO:0021766,GO:0021879,GO:0021893,GO:0030154,GO:0030514,GO:0042475,GO:0043524,GO:0045597,GO:0045746,GO:0045944,GO:0046533,GO:0048706,GO:0048715,GO:0071560,GO:0071773,GO:1902871,GO:1903845,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|chromatin binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|embryo development|proximal/distal pattern formation|subpallium development|hippocampus development|forebrain neuron differentiation|cerebral cortex GABAergic interneuron fate commitment|cell differentiation|negative regulation of BMP signaling pathway|odontogenesis of dentin-containing tooth|negative regulation of neuron apoptotic process|positive regulation of cell differentiation|negative regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|negative regulation of photoreceptor cell differentiation|embryonic skeletal system development|negative regulation of oligodendrocyte differentiation|cellular response to transforming growth factor beta stimulus|cellular response to BMP stimulus|positive regulation of amacrine cell differentiation|negative regulation of cellular response to transforming growth factor beta stimulus|sequence-specific double-stranded DNA binding" DLX2 60.73084837 55.14193578 66.31976096 1.202710061 0.266288892 0.652158097 1 1.199194689 1.418148856 1746 distal-less homeobox 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003682,GO:0003700,GO:0003727,GO:0005515,GO:0005634,GO:0006357,GO:0007420,GO:0009790,GO:0009954,GO:0021544,GO:0021766,GO:0021772,GO:0021879,GO:0021893,GO:0030154,GO:0042475,GO:0045597,GO:0045746,GO:0045944,GO:0046533,GO:0048701,GO:0048715,GO:0048755,GO:0051216,GO:1902871,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|chromatin binding|DNA-binding transcription factor activity|single-stranded RNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|brain development|embryo development|proximal/distal pattern formation|subpallium development|hippocampus development|olfactory bulb development|forebrain neuron differentiation|cerebral cortex GABAergic interneuron fate commitment|cell differentiation|odontogenesis of dentin-containing tooth|positive regulation of cell differentiation|negative regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|negative regulation of photoreceptor cell differentiation|embryonic cranial skeleton morphogenesis|negative regulation of oligodendrocyte differentiation|branching morphogenesis of a nerve|cartilage development|positive regulation of amacrine cell differentiation|sequence-specific double-stranded DNA binding" Homeobox DLX4 6.083967443 8.323311061 3.844623824 0.461910386 -1.11431511 0.492415049 1 0.179040634 0.081316844 1748 distal-less homeobox 4 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0007275,GO:0009790,GO:0030154,GO:0043565,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|embryo development|cell differentiation|sequence-specific DNA binding|sequence-specific double-stranded DNA binding" Homeobox DLX5 12.8516881 9.363724944 16.33965125 1.744994791 0.80322273 0.460499144 1 0.158341188 0.271680966 1749 distal-less homeobox 5 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001501,GO:0001649,GO:0001958,GO:0005634,GO:0005737,GO:0006357,GO:0007399,GO:0008283,GO:0009790,GO:0021889,GO:0030154,GO:0030326,GO:0030509,GO:0030855,GO:0042472,GO:0045893,GO:0048646,GO:0050679,GO:0060021,GO:0060166,GO:0060325,GO:0071773,GO:0071837,GO:0090263,GO:0097376,GO:1901522,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|skeletal system development|osteoblast differentiation|endochondral ossification|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|nervous system development|cell population proliferation|embryo development|olfactory bulb interneuron differentiation|cell differentiation|embryonic limb morphogenesis|BMP signaling pathway|epithelial cell differentiation|inner ear morphogenesis|positive regulation of transcription, DNA-templated|anatomical structure formation involved in morphogenesis|positive regulation of epithelial cell proliferation|roof of mouth development|olfactory pit development|face morphogenesis|cellular response to BMP stimulus|HMG box domain binding|positive regulation of canonical Wnt signaling pathway|interneuron axon guidance|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|sequence-specific double-stranded DNA binding" hsa04550 Signaling pathways regulating pluripotency of stem cells DLX6 4.444088692 3.121241648 5.766935736 1.847641543 0.88568489 0.705170935 1 0.072423883 0.131574189 1750 distal-less homeobox 6 "GO:0000785,GO:0000978,GO:0000981,GO:0001501,GO:0003700,GO:0005634,GO:0006357,GO:0007399,GO:0009790,GO:0030154,GO:0030326,GO:0030855,GO:0042472,GO:0048646,GO:0050679,GO:0060021,GO:0060322,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|skeletal system development|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|nervous system development|embryo development|cell differentiation|embryonic limb morphogenesis|epithelial cell differentiation|inner ear morphogenesis|anatomical structure formation involved in morphogenesis|positive regulation of epithelial cell proliferation|roof of mouth development|head development|sequence-specific double-stranded DNA binding" DMAC1 438.1657715 400.5593448 475.7721982 1.187769564 0.248254969 0.381090335 1 8.661716384 10.11596528 90871 distal membrane arm assembly component 1 "GO:0005743,GO:0005747,GO:0016021,GO:0032981" mitochondrial inner membrane|mitochondrial respiratory chain complex I|integral component of membrane|mitochondrial respiratory chain complex I assembly DMAC2 510.8909477 505.641147 516.1407484 1.020764927 0.029650664 0.920722179 1 14.41513819 14.46824079 55101 distal membrane arm assembly component 2 "GO:0005747,GO:0019005,GO:0031146,GO:0032981" mitochondrial respiratory chain complex I|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|mitochondrial respiratory chain complex I assembly DMAC2L 149.597531 155.0216685 144.1733934 0.930020911 -0.10466494 0.810981637 1 1.157417674 1.058410164 27109 distal membrane arm assembly component 2 like "GO:0005743,GO:0006754,GO:0015078,GO:0042407,GO:0042776,GO:0045263,GO:0046872,GO:1902600" "mitochondrial inner membrane|ATP biosynthetic process|proton transmembrane transporter activity|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase complex, coupling factor F(o)|metal ion binding|proton transmembrane transport" DMAP1 557.328374 551.4193578 563.2373902 1.021432023 0.030593195 0.915720572 1 18.85217019 18.93398373 55929 DNA methyltransferase 1 associated protein 1 "GO:0000122,GO:0000812,GO:0001103,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0005737,GO:0005829,GO:0006281,GO:0006306,GO:0035267,GO:0040008,GO:0042307,GO:0043486,GO:0043967,GO:0043968,GO:0045471,GO:0045892" "negative regulation of transcription by RNA polymerase II|Swr1 complex|RNA polymerase II repressing transcription factor binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|replication fork|cytoplasm|cytosol|DNA repair|DNA methylation|NuA4 histone acetyltransferase complex|regulation of growth|positive regulation of protein import into nucleus|histone exchange|histone H4 acetylation|histone H2A acetylation|response to ethanol|negative regulation of transcription, DNA-templated" DMBX1 5.885822626 3.121241648 8.650403604 2.771462315 1.470647391 0.36367629 1 0.052316247 0.142566254 127343 diencephalon/mesencephalon homeobox 1 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0003677,GO:0003700,GO:0005634,GO:0005667,GO:0006357,GO:0007417,GO:0007420,GO:0008343,GO:0008344,GO:0042802,GO:0043565,GO:0045892,GO:0048589,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|central nervous system development|brain development|adult feeding behavior|adult locomotory behavior|identical protein binding|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|developmental growth|sequence-specific double-stranded DNA binding" DMC1 3.923881751 2.080827765 5.766935736 2.771462315 1.470647391 0.503574097 1 0.041953137 0.114325891 11144 DNA meiotic recombinase 1 "GO:0000150,GO:0000730,GO:0000781,GO:0000794,GO:0001541,GO:0001556,GO:0003677,GO:0003690,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005694,GO:0006312,GO:0007129,GO:0007131,GO:0007141,GO:0007283,GO:0007286,GO:0007292,GO:0008094,GO:0010212,GO:0042148,GO:0042802,GO:0051321,GO:0070192" "recombinase activity|DNA recombinase assembly|chromosome, telomeric region|condensed nuclear chromosome|ovarian follicle development|oocyte maturation|DNA binding|double-stranded DNA binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|chromosome|mitotic recombination|homologous chromosome pairing at meiosis|reciprocal meiotic recombination|male meiosis I|spermatogenesis|spermatid development|female gamete generation|DNA-dependent ATPase activity|response to ionizing radiation|strand invasion|identical protein binding|meiotic cell cycle|chromosome organization involved in meiotic cell cycle" DMD 527.675964 593.0359131 462.3160148 0.779575072 -0.359240135 0.183319972 1 1.338064378 1.025666406 1756 dystrophin "GO:0002027,GO:0002162,GO:0003779,GO:0005200,GO:0005515,GO:0005829,GO:0005856,GO:0007010,GO:0007517,GO:0008270,GO:0008307,GO:0009986,GO:0010880,GO:0010881,GO:0014809,GO:0014819,GO:0016010,GO:0016013,GO:0016328,GO:0017022,GO:0017166,GO:0030018,GO:0030049,GO:0030055,GO:0030175,GO:0031527,GO:0032991,GO:0033137,GO:0034613,GO:0034622,GO:0035633,GO:0035994,GO:0042383,GO:0043034,GO:0043043,GO:0044306,GO:0045121,GO:0045202,GO:0045211,GO:0046716,GO:0048747,GO:0050998,GO:0060048,GO:0060314,GO:0086001,GO:1901385,GO:1902083,GO:2000651" regulation of heart rate|dystroglycan binding|actin binding|structural constituent of cytoskeleton|protein binding|cytosol|cytoskeleton|cytoskeleton organization|muscle organ development|zinc ion binding|structural constituent of muscle|cell surface|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion|regulation of skeletal muscle contraction|dystrophin-associated glycoprotein complex|syntrophin complex|lateral plasma membrane|myosin binding|vinculin binding|Z disc|muscle filament sliding|cell-substrate junction|filopodium|filopodium membrane|protein-containing complex|negative regulation of peptidyl-serine phosphorylation|cellular protein localization|cellular protein-containing complex assembly|maintenance of blood-brain barrier|response to muscle stretch|sarcolemma|costamere|peptide biosynthetic process|neuron projection terminus|membrane raft|synapse|postsynaptic membrane|muscle cell cellular homeostasis|muscle fiber development|nitric-oxide synthase binding|cardiac muscle contraction|regulation of ryanodine-sensitive calcium-release channel activity|cardiac muscle cell action potential|regulation of voltage-gated calcium channel activity|negative regulation of peptidyl-cysteine S-nitrosylation|positive regulation of sodium ion transmembrane transporter activity "hsa05410,hsa05412,hsa05414,hsa05416" Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Viral myocarditis DMGDH 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.012864916 0.017528999 29958 dimethylglycine dehydrogenase "GO:0003723,GO:0005737,GO:0005739,GO:0005759,GO:0006579,GO:0009055,GO:0016491,GO:0019695,GO:0022900,GO:0042426,GO:0047865" RNA binding|cytoplasm|mitochondrion|mitochondrial matrix|amino-acid betaine catabolic process|electron transfer activity|oxidoreductase activity|choline metabolic process|electron transport chain|choline catabolic process|dimethylglycine dehydrogenase activity hsa00260 "Glycine, serine and threonine metabolism" DMKN 7.927021428 6.242483296 9.61155956 1.539701286 0.622650484 0.695278173 1 0.130493482 0.197558842 93099 dermokine "GO:0005515,GO:0005615,GO:1903575" protein binding|extracellular space|cornified envelope assembly DMPK 382.4388477 350.6194785 414.258217 1.181503717 0.240624168 0.413741587 1 6.323730028 7.346484923 1760 DM1 protein kinase "GO:0002028,GO:0004674,GO:0005515,GO:0005524,GO:0005640,GO:0005789,GO:0005829,GO:0005886,GO:0006468,GO:0006874,GO:0006998,GO:0008016,GO:0010657,GO:0010830,GO:0014722,GO:0014853,GO:0017020,GO:0018105,GO:0031307,GO:0031965,GO:0033017,GO:0035556,GO:0043666,GO:0046872,GO:0051823,GO:0106310,GO:0106311,GO:1903779" regulation of sodium ion transport|protein serine/threonine kinase activity|protein binding|ATP binding|nuclear outer membrane|endoplasmic reticulum membrane|cytosol|plasma membrane|protein phosphorylation|cellular calcium ion homeostasis|nuclear envelope organization|regulation of heart contraction|muscle cell apoptotic process|regulation of myotube differentiation|regulation of skeletal muscle contraction by calcium ion signaling|regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction|myosin phosphatase regulator activity|peptidyl-serine phosphorylation|integral component of mitochondrial outer membrane|nuclear membrane|sarcoplasmic reticulum membrane|intracellular signal transduction|regulation of phosphoprotein phosphatase activity|metal ion binding|regulation of synapse structural plasticity|protein serine kinase activity|protein threonine kinase activity|regulation of cardiac conduction DMRTA1 122.214647 130.0517353 114.3775588 0.879477375 -0.185281631 0.683629624 1 1.242503059 1.074467582 63951 DMRT like family A1 "GO:0000785,GO:0000978,GO:0000981,GO:0001541,GO:0005515,GO:0005634,GO:0006357,GO:0007281,GO:0007548,GO:0042802,GO:0046872,GO:0060179,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|ovarian follicle development|protein binding|nucleus|regulation of transcription by RNA polymerase II|germ cell development|sex differentiation|identical protein binding|metal ion binding|male mating behavior|sequence-specific double-stranded DNA binding" DMTF1 1838.892907 1885.229955 1792.555858 0.950842019 -0.072722435 0.760640976 1 13.13120045 12.27676592 9988 cyclin D binding myb like transcription factor 1 "GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006357,GO:0007049,GO:0045944" "transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|cell cycle|positive regulation of transcription by RNA polymerase II" DMTN 311.670582 259.0630568 364.2781073 1.406136837 0.491736996 0.113876886 1 3.364740619 4.652114073 2039 dematin actin binding protein "GO:0003779,GO:0005102,GO:0005515,GO:0005829,GO:0005884,GO:0005886,GO:0007010,GO:0008360,GO:0010591,GO:0010763,GO:0010801,GO:0010812,GO:0012505,GO:0014069,GO:0014731,GO:0015629,GO:0030032,GO:0030036,GO:0030194,GO:0030507,GO:0030863,GO:0031095,GO:0031253,GO:0031410,GO:0032956,GO:0033137,GO:0035584,GO:0035585,GO:0043621,GO:0048471,GO:0048821,GO:0050732,GO:0051015,GO:0051017,GO:0051489,GO:0051693,GO:0051895,GO:0055085,GO:0065003,GO:0070560,GO:0071277,GO:0071320,GO:0090303,GO:0090315,GO:0090527,GO:1900025,GO:1900026,GO:1901731,GO:2001046" actin binding|signaling receptor binding|protein binding|cytosol|actin filament|plasma membrane|cytoskeleton organization|regulation of cell shape|regulation of lamellipodium assembly|positive regulation of fibroblast migration|negative regulation of peptidyl-threonine phosphorylation|negative regulation of cell-substrate adhesion|endomembrane system|postsynaptic density|spectrin-associated cytoskeleton|actin cytoskeleton|lamellipodium assembly|actin cytoskeleton organization|positive regulation of blood coagulation|spectrin binding|cortical cytoskeleton|platelet dense tubular network membrane|cell projection membrane|cytoplasmic vesicle|regulation of actin cytoskeleton organization|negative regulation of peptidyl-serine phosphorylation|calcium-mediated signaling using intracellular calcium source|calcium-mediated signaling using extracellular calcium source|protein self-association|perinuclear region of cytoplasm|erythrocyte development|negative regulation of peptidyl-tyrosine phosphorylation|actin filament binding|actin filament bundle assembly|regulation of filopodium assembly|actin filament capping|negative regulation of focal adhesion assembly|transmembrane transport|protein-containing complex assembly|protein secretion by platelet|cellular response to calcium ion|cellular response to cAMP|positive regulation of wound healing|negative regulation of protein targeting to membrane|actin filament reorganization|negative regulation of substrate adhesion-dependent cell spreading|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of platelet aggregation|positive regulation of integrin-mediated signaling pathway DMWD 371.3604022 413.0443114 329.6764929 0.798162531 -0.325245541 0.271338928 1 6.464344797 5.073258921 1762 "DM1 locus, WD repeat containing" "GO:0003674,GO:0005575,GO:0005634,GO:0030425,GO:0043204" molecular_function|cellular_component|nucleus|dendrite|perikaryon DMXL1 944.1264077 1016.484363 871.7684521 0.857630952 -0.221571121 0.370696285 1 4.718439789 3.978964298 1657 Dmx like 1 "GO:0007035,GO:0043291" vacuolar acidification|RAVE complex DMXL2 1753.321073 1758.299462 1748.342684 0.994337269 -0.008192813 0.975126962 1 8.421935977 8.234113169 23312 Dmx like 2 "GO:0005615,GO:0007035,GO:0008021,GO:0030672,GO:0031267,GO:0043291,GO:0098992" extracellular space|vacuolar acidification|synaptic vesicle|synaptic vesicle membrane|small GTPase binding|RAVE complex|neuronal dense core vesicle DNA2 891.2389068 877.0689031 905.4089105 1.032312179 0.045879319 0.857845946 1 10.38782853 10.54403896 1763 DNA replication helicase/nuclease 2 "GO:0000076,GO:0000723,GO:0000729,GO:0000781,GO:0003677,GO:0003678,GO:0003723,GO:0004386,GO:0004518,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005760,GO:0006260,GO:0006264,GO:0006284,GO:0016887,GO:0016890,GO:0017108,GO:0017116,GO:0032201,GO:0032508,GO:0033567,GO:0042645,GO:0043137,GO:0043139,GO:0043504,GO:0044806,GO:0045740,GO:0046872,GO:0051539,GO:0071932,GO:0090305,GO:0090656,GO:1901796,GO:1902990" "DNA replication checkpoint|telomere maintenance|DNA double-strand break processing|chromosome, telomeric region|DNA binding|DNA helicase activity|RNA binding|helicase activity|nuclease activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|gamma DNA polymerase complex|DNA replication|mitochondrial DNA replication|base-excision repair|ATPase activity|site-specific endodeoxyribonuclease activity, specific for altered base|5'-flap endonuclease activity|single-stranded DNA helicase activity|telomere maintenance via semi-conservative replication|DNA duplex unwinding|DNA replication, Okazaki fragment processing|mitochondrial nucleoid|DNA replication, removal of RNA primer|5'-3' DNA helicase activity|mitochondrial DNA repair|G-quadruplex DNA unwinding|positive regulation of DNA replication|metal ion binding|4 iron, 4 sulfur cluster binding|replication fork reversal|nucleic acid phosphodiester bond hydrolysis|t-circle formation|regulation of signal transduction by p53 class mediator|mitotic telomere maintenance via semi-conservative replication" hsa03030 DNA replication DNAAF10 256.409145 246.5780902 266.2401998 1.079739889 0.110683807 0.748238906 1 4.10078513 4.353688359 116143 dynein axonemal assembly factor 10 DNAAF11 149.518273 152.9408407 146.0957053 0.955243247 -0.066059941 0.887100789 1 1.506213615 1.414724008 23639 dynein axonemal assembly factor 11 DNAAF2 287.4234167 303.8008537 271.0459796 0.892183074 -0.164588316 0.613290422 1 5.446185153 4.777685524 55172 dynein axonemal assembly factor 2 "GO:0001539,GO:0001701,GO:0003351,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0032526,GO:0036158,GO:0036159,GO:0060285,GO:0061966,GO:0070286" cilium or flagellum-dependent cell motility|in utero embryonic development|epithelial cilium movement involved in extracellular fluid movement|protein binding|extracellular region|cytoplasm|cytosol|response to retinoic acid|outer dynein arm assembly|inner dynein arm assembly|cilium-dependent cell motility|establishment of left/right asymmetry|axonemal dynein complex assembly DNAAF3 120.1338193 125.8900798 114.3775588 0.908551007 -0.138360584 0.767833911 1 3.0414315 2.717055641 352909 dynein axonemal assembly factor 3 "GO:0005737,GO:0044458,GO:0070286" cytoplasm|motile cilium assembly|axonemal dynein complex assembly DNAAF4 47.1557781 52.02069413 42.29086206 0.812962279 -0.298739681 0.646468193 1 1.17042531 0.935589369 161582 dynein axonemal assembly factor 4 "GO:0001764,GO:0003341,GO:0003351,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0007368,GO:0007507,GO:0030331,GO:0033146,GO:0036158,GO:0036159,GO:0061136,GO:0097730" neuron migration|cilium movement|epithelial cilium movement involved in extracellular fluid movement|protein binding|extracellular region|nucleus|cytoplasm|centrosome|cytosol|plasma membrane|determination of left/right symmetry|heart development|estrogen receptor binding|regulation of intracellular estrogen receptor signaling pathway|outer dynein arm assembly|inner dynein arm assembly|regulation of proteasomal protein catabolic process|non-motile cilium DNAAF5 1313.381444 1386.871706 1239.891183 0.894020102 -0.161620825 0.502608941 1 18.97328735 16.67865582 54919 dynein axonemal assembly factor 5 "GO:0003341,GO:0005737,GO:0031514,GO:0036158,GO:0036159,GO:0045505" cilium movement|cytoplasm|motile cilium|outer dynein arm assembly|inner dynein arm assembly|dynein intermediate chain binding DNAAF8 1.922311912 0 3.844623824 Inf Inf 0.288176591 1 0 0.069305081 146562 dynein axonemal assembly factor 8 DNAAF9 891.1948618 787.5933092 994.7964145 1.263083882 0.336950452 0.175379686 1 5.54078663 6.88136823 25943 dynein axonemal assembly factor 9 DNAH1 65.04598934 80.11186896 49.98010971 0.623878963 -0.680661932 0.21271976 1 0.258755868 0.158730991 25981 dynein axonemal heavy chain 1 "GO:0003341,GO:0003777,GO:0005524,GO:0005858,GO:0005874,GO:0005930,GO:0007018,GO:0007288,GO:0008569,GO:0030286,GO:0030317,GO:0036126,GO:0036156,GO:0036159,GO:0045505,GO:0051959,GO:0060285" "cilium movement|microtubule motor activity|ATP binding|axonemal dynein complex|microtubule|axoneme|microtubule-based movement|sperm axoneme assembly|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|flagellated sperm motility|sperm flagellum|inner dynein arm|inner dynein arm assembly|dynein intermediate chain binding|dynein light intermediate chain binding|cilium-dependent cell motility" "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAH11 41.39387278 39.53572754 43.25201802 1.093998282 0.129610473 0.876958195 1 0.147106541 0.158241285 8701 dynein axonemal heavy chain 11 "GO:0003341,GO:0003356,GO:0005524,GO:0005874,GO:0005930,GO:0007018,GO:0007368,GO:0008569,GO:0030286,GO:0030317,GO:0031514,GO:0045505,GO:0051959,GO:0097729,GO:0120134" "cilium movement|regulation of cilium beat frequency|ATP binding|microtubule|axoneme|microtubule-based movement|determination of left/right symmetry|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|flagellated sperm motility|motile cilium|dynein intermediate chain binding|dynein light intermediate chain binding|9+2 motile cilium|proximal portion of axoneme" "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAH12 6.485287494 6.242483296 6.728091692 1.0777909 0.108077311 1 1 0.025386715 0.026903712 201625 dynein axonemal heavy chain 12 "GO:0005524,GO:0005737,GO:0005874,GO:0005929,GO:0007018,GO:0008569,GO:0030286" "ATP binding|cytoplasm|microtubule|cilium|microtubule-based movement|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex" "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAH14 389.8010028 367.2661006 412.3359051 1.122717029 0.166994354 0.57093751 1 0.920073078 1.015696162 127602 dynein axonemal heavy chain 14 "GO:0005524,GO:0005858,GO:0005874,GO:0007018,GO:0008569,GO:0030286,GO:0045505,GO:0051959,GO:0060285" "ATP binding|axonemal dynein complex|microtubule|microtubule-based movement|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|dynein intermediate chain binding|dynein light intermediate chain binding|cilium-dependent cell motility" "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAH17 7.243268215 13.52538047 0.961155956 0.071063136 -3.814754828 0.020868228 0.821508434 0.052279619 0.003652986 8632 dynein axonemal heavy chain 17 "GO:0003341,GO:0003777,GO:0005524,GO:0005858,GO:0005874,GO:0005930,GO:0007018,GO:0008569,GO:0030286,GO:0031514,GO:0036126,GO:0036157,GO:0036158,GO:0045505,GO:0051959,GO:0060285" "cilium movement|microtubule motor activity|ATP binding|axonemal dynein complex|microtubule|axoneme|microtubule-based movement|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|motile cilium|sperm flagellum|outer dynein arm|outer dynein arm assembly|dynein intermediate chain binding|dynein light intermediate chain binding|cilium-dependent cell motility" "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAH3 3.562190663 5.202069413 1.922311912 0.369528309 -1.436243205 0.543489417 1 0.019040181 0.00691815 55567 dynein axonemal heavy chain 3 "GO:0003777,GO:0005524,GO:0005858,GO:0005874,GO:0007018,GO:0008569,GO:0030286,GO:0045505,GO:0051959,GO:0060285" "microtubule motor activity|ATP binding|axonemal dynein complex|microtubule|microtubule-based movement|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|dynein intermediate chain binding|dynein light intermediate chain binding|cilium-dependent cell motility" "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAH5 157.5295828 148.7791852 166.2799804 1.117629325 0.160441781 0.698384391 1 0.396053056 0.43523352 1767 dynein axonemal heavy chain 5 "GO:0003341,GO:0003351,GO:0005524,GO:0005576,GO:0005737,GO:0005874,GO:0005930,GO:0007018,GO:0007368,GO:0007507,GO:0008569,GO:0021670,GO:0030286,GO:0030317,GO:0031514,GO:0036157,GO:0036158,GO:0045505,GO:0051649,GO:0051959,GO:0060271,GO:0097729" "cilium movement|epithelial cilium movement involved in extracellular fluid movement|ATP binding|extracellular region|cytoplasm|microtubule|axoneme|microtubule-based movement|determination of left/right symmetry|heart development|ATP-dependent microtubule motor activity, minus-end-directed|lateral ventricle development|dynein complex|flagellated sperm motility|motile cilium|outer dynein arm|outer dynein arm assembly|dynein intermediate chain binding|establishment of localization in cell|dynein light intermediate chain binding|cilium assembly|9+2 motile cilium" "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAH6 9.725416032 15.60620824 3.844623824 0.246352206 -2.021205706 0.094673133 1 0.058611868 0.014197543 1768 dynein axonemal heavy chain 6 "GO:0005524,GO:0005858,GO:0005874,GO:0007018,GO:0008569,GO:0030286,GO:0045505,GO:0051959,GO:0060285" "ATP binding|axonemal dynein complex|microtubule|microtubule-based movement|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|dynein intermediate chain binding|dynein light intermediate chain binding|cilium-dependent cell motility" "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAH7 60.77047734 56.18234966 65.35860501 1.163329861 0.218260229 0.717530619 1 0.236556114 0.270587812 56171 dynein axonemal heavy chain 7 "GO:0003341,GO:0003777,GO:0005509,GO:0005524,GO:0005829,GO:0005858,GO:0005874,GO:0005929,GO:0007018,GO:0008569,GO:0030286,GO:0036156,GO:0036159,GO:0045505,GO:0051959,GO:0060285" "cilium movement|microtubule motor activity|calcium ion binding|ATP binding|cytosol|axonemal dynein complex|microtubule|cilium|microtubule-based movement|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|inner dynein arm|inner dynein arm assembly|dynein intermediate chain binding|dynein light intermediate chain binding|cilium-dependent cell motility" "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAI3 11.127521 14.56579436 7.689247648 0.527897584 -0.921670032 0.421966432 1 0.259983169 0.134947886 126820 dynein axonemal intermediate chain 3 "GO:0005515,GO:0005737,GO:0005858,GO:0007018,GO:0030336,GO:0034316,GO:0036156,GO:0036159,GO:0045503,GO:0045504,GO:0045669,GO:0060294,GO:0071933" protein binding|cytoplasm|axonemal dynein complex|microtubule-based movement|negative regulation of cell migration|negative regulation of Arp2/3 complex-mediated actin nucleation|inner dynein arm|inner dynein arm assembly|dynein light chain binding|dynein heavy chain binding|positive regulation of osteoblast differentiation|cilium movement involved in cell motility|Arp2/3 complex binding DNAI4 18.05375751 19.76786377 16.33965125 0.82657648 -0.274779782 0.809952665 1 0.24776293 0.201368044 79819 dynein axonemal intermediate chain 4 "GO:0002244,GO:0003341,GO:0005858,GO:0005930,GO:0007018,GO:0031514,GO:0045503,GO:0045504,GO:0070286" hematopoietic progenitor cell differentiation|cilium movement|axonemal dynein complex|axoneme|microtubule-based movement|motile cilium|dynein light chain binding|dynein heavy chain binding|axonemal dynein complex assembly DNAI7 5.083182523 7.282897178 2.883467868 0.395923188 -1.336707531 0.4551609 1 0.115745931 0.045059654 55259 dynein axonemal intermediate chain 7 DNAJA1 5125.661123 4928.440562 5322.881684 1.080033657 0.111076272 0.644260328 1 113.4203599 120.4479713 3301 DnaJ heat shock protein family (Hsp40) member A1 "GO:0001664,GO:0001671,GO:0005515,GO:0005524,GO:0005634,GO:0005739,GO:0005829,GO:0006457,GO:0006986,GO:0007283,GO:0009408,GO:0015630,GO:0016020,GO:0030317,GO:0030521,GO:0030544,GO:0030957,GO:0031397,GO:0031625,GO:0032781,GO:0042769,GO:0043065,GO:0043066,GO:0043508,GO:0046872,GO:0048471,GO:0050750,GO:0051082,GO:0051087,GO:0051223,GO:0055131,GO:0070062,GO:0070585,GO:0098554,GO:1901998,GO:1903748,GO:1905259" "G protein-coupled receptor binding|ATPase activator activity|protein binding|ATP binding|nucleus|mitochondrion|cytosol|protein folding|response to unfolded protein|spermatogenesis|response to heat|microtubule cytoskeleton|membrane|flagellated sperm motility|androgen receptor signaling pathway|Hsp70 protein binding|Tat protein binding|negative regulation of protein ubiquitination|ubiquitin protein ligase binding|positive regulation of ATPase activity|DNA damage response, detection of DNA damage|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of JUN kinase activity|metal ion binding|perinuclear region of cytoplasm|low-density lipoprotein particle receptor binding|unfolded protein binding|chaperone binding|regulation of protein transport|C3HC4-type RING finger domain binding|extracellular exosome|protein localization to mitochondrion|cytoplasmic side of endoplasmic reticulum membrane|toxin transport|negative regulation of establishment of protein localization to mitochondrion|negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" hsa04141 Protein processing in endoplasmic reticulum DNAJA2 2183.49124 2024.645416 2342.337065 1.156912241 0.210279431 0.37405749 1 35.92141113 40.86250474 10294 DnaJ heat shock protein family (Hsp40) member A2 "GO:0001671,GO:0005515,GO:0005524,GO:0005829,GO:0008284,GO:0009408,GO:0016020,GO:0031072,GO:0032781,GO:0042026,GO:0046872,GO:0051082,GO:0051087,GO:0070062" ATPase activator activity|protein binding|ATP binding|cytosol|positive regulation of cell population proliferation|response to heat|membrane|heat shock protein binding|positive regulation of ATPase activity|protein refolding|metal ion binding|unfolded protein binding|chaperone binding|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum DNAJA3 1198.335838 1255.779556 1140.89212 0.908513054 -0.138420851 0.569106408 1 24.82172107 22.17349955 9093 DnaJ heat shock protein family (Hsp40) member A3 "GO:0000122,GO:0005515,GO:0005524,GO:0005634,GO:0005739,GO:0005759,GO:0005829,GO:0005884,GO:0006264,GO:0006457,GO:0006924,GO:0007005,GO:0007264,GO:0007569,GO:0008285,GO:0009408,GO:0019897,GO:0030544,GO:0030695,GO:0031594,GO:0033077,GO:0042102,GO:0042981,GO:0043069,GO:0043231,GO:0045211,GO:0046872,GO:0050790,GO:0051082,GO:0071340" negative regulation of transcription by RNA polymerase II|protein binding|ATP binding|nucleus|mitochondrion|mitochondrial matrix|cytosol|actin filament|mitochondrial DNA replication|protein folding|activation-induced cell death of T cells|mitochondrion organization|small GTPase mediated signal transduction|cell aging|negative regulation of cell population proliferation|response to heat|extrinsic component of plasma membrane|Hsp70 protein binding|GTPase regulator activity|neuromuscular junction|T cell differentiation in thymus|positive regulation of T cell proliferation|regulation of apoptotic process|negative regulation of programmed cell death|intracellular membrane-bounded organelle|postsynaptic membrane|metal ion binding|regulation of catalytic activity|unfolded protein binding|skeletal muscle acetylcholine-gated channel clustering hsa05203 Viral carcinogenesis DNAJA4 265.4854064 282.9925761 247.9782366 0.876271173 -0.190550696 0.567255977 1 4.528573813 3.901855253 55466 DnaJ heat shock protein family (Hsp40) member A4 "GO:0005515,GO:0005524,GO:0005829,GO:0009408,GO:0010596,GO:0010628,GO:0016020,GO:0031072,GO:0042026,GO:0046872,GO:0051082,GO:0051087,GO:0090084" protein binding|ATP binding|cytosol|response to heat|negative regulation of endothelial cell migration|positive regulation of gene expression|membrane|heat shock protein binding|protein refolding|metal ion binding|unfolded protein binding|chaperone binding|negative regulation of inclusion body assembly DNAJB1 2085.155808 2067.302385 2103.009232 1.017272194 0.024705756 0.918877354 1 27.02133939 27.02808178 3337 DnaJ heat shock protein family (Hsp40) member B1 "GO:0000122,GO:0001671,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006986,GO:0014069,GO:0030544,GO:0030900,GO:0032781,GO:0043025,GO:0043197,GO:0044183,GO:0045296,GO:0051082,GO:0051085,GO:0051087,GO:0051117,GO:0061827,GO:0070062,GO:0090084,GO:0097201,GO:0098978,GO:1900034" negative regulation of transcription by RNA polymerase II|ATPase activator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|response to unfolded protein|postsynaptic density|Hsp70 protein binding|forebrain development|positive regulation of ATPase activity|neuronal cell body|dendritic spine|protein folding chaperone|cadherin binding|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding|ATPase binding|sperm head|extracellular exosome|negative regulation of inclusion body assembly|negative regulation of transcription from RNA polymerase II promoter in response to stress|glutamatergic synapse|regulation of cellular response to heat "hsa04141,hsa05164" Protein processing in endoplasmic reticulum|Influenza A DNAJB11 1322.869087 1396.235431 1249.502743 0.894908348 -0.160188158 0.50620927 1 45.43568217 39.98036834 51726 DnaJ heat shock protein family (Hsp40) member B11 "GO:0005515,GO:0005783,GO:0005788,GO:0006457,GO:0016020,GO:0032781,GO:0036498,GO:0051082,GO:0051604,GO:0051787,GO:0101031" protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|protein folding|membrane|positive regulation of ATPase activity|IRE1-mediated unfolded protein response|unfolded protein binding|protein maturation|misfolded protein binding|chaperone complex hsa04141 Protein processing in endoplasmic reticulum DNAJB12 1371.769154 1393.114189 1350.424118 0.969356374 -0.04490094 0.854277189 1 18.14692307 17.29647673 54788 DnaJ heat shock protein family (Hsp40) member B12 "GO:0005783,GO:0005789,GO:0016020,GO:0016032,GO:0030176,GO:0030433,GO:0030544,GO:0031965,GO:0034622,GO:0036503,GO:0051085,GO:0071218" endoplasmic reticulum|endoplasmic reticulum membrane|membrane|viral process|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|Hsp70 protein binding|nuclear membrane|cellular protein-containing complex assembly|ERAD pathway|chaperone cofactor-dependent protein refolding|cellular response to misfolded protein hsa04141 Protein processing in endoplasmic reticulum DNAJB14 934.0053164 889.5538697 978.4567632 1.099940989 0.137426126 0.580741461 1 7.400445065 8.003840103 79982 DnaJ heat shock protein family (Hsp40) member B14 "GO:0005783,GO:0005789,GO:0016020,GO:0016021,GO:0016032,GO:0030433,GO:0030544,GO:0031965,GO:0034622,GO:0051085,GO:0071218" endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane|viral process|ubiquitin-dependent ERAD pathway|Hsp70 protein binding|nuclear membrane|cellular protein-containing complex assembly|chaperone cofactor-dependent protein refolding|cellular response to misfolded protein DNAJB2 647.0021127 735.572615 558.4316104 0.759179446 -0.397487161 0.125323693 1 20.43527253 15.25443245 3300 DnaJ heat shock protein family (Hsp40) member B2 "GO:0000502,GO:0001671,GO:0005515,GO:0005634,GO:0005829,GO:0006986,GO:0008285,GO:0030308,GO:0030433,GO:0030544,GO:0031227,GO:0031396,GO:0031965,GO:0032091,GO:0032436,GO:0032781,GO:0042026,GO:0043130,GO:0051082,GO:0051087,GO:0061077,GO:0070050,GO:0090084,GO:0140036,GO:1903644" proteasome complex|ATPase activator activity|protein binding|nucleus|cytosol|response to unfolded protein|negative regulation of cell population proliferation|negative regulation of cell growth|ubiquitin-dependent ERAD pathway|Hsp70 protein binding|intrinsic component of endoplasmic reticulum membrane|regulation of protein ubiquitination|nuclear membrane|negative regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ATPase activity|protein refolding|ubiquitin binding|unfolded protein binding|chaperone binding|chaperone-mediated protein folding|neuron cellular homeostasis|negative regulation of inclusion body assembly|ubiquitin-dependent protein binding|regulation of chaperone-mediated protein folding hsa04141 Protein processing in endoplasmic reticulum DNAJB4 377.6972346 390.155206 365.2392633 0.936138382 -0.095206287 0.7530281 1 6.359763674 5.853993127 11080 DnaJ heat shock protein family (Hsp40) member B4 "GO:0001671,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006986,GO:0009408,GO:0032781,GO:0051082,GO:0051085,GO:0051087" ATPase activator activity|protein binding|nucleoplasm|cytosol|plasma membrane|response to unfolded protein|response to heat|positive regulation of ATPase activity|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding DNAJB5 1017.343451 894.7559391 1139.930964 1.274013297 0.349380335 0.154675328 1 16.06711978 20.12719112 25822 DnaJ heat shock protein family (Hsp40) member B5 "GO:0005515,GO:0005829,GO:0006986,GO:0051082,GO:0051085,GO:0051087" protein binding|cytosol|response to unfolded protein|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding DNAJB6 3902.424549 3649.7719 4155.077198 1.13844846 0.187068979 0.431997972 1 67.32859258 75.36749634 10049 DnaJ heat shock protein family (Hsp40) member B6 "GO:0001671,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006457,GO:0016020,GO:0030018,GO:0031072,GO:0032781,GO:0032880,GO:0043154,GO:0045109,GO:0048471,GO:0051082,GO:0051087,GO:0090084,GO:1900034" ATPase activator activity|protein binding|nucleus|nucleoplasm|cytosol|protein folding|membrane|Z disc|heat shock protein binding|positive regulation of ATPase activity|regulation of protein localization|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|intermediate filament organization|perinuclear region of cytoplasm|unfolded protein binding|chaperone binding|negative regulation of inclusion body assembly|regulation of cellular response to heat DNAJB9 340.1580465 325.6495453 354.6665478 1.089104999 0.123143049 0.691132382 1 7.214328648 7.725682441 4189 DnaJ heat shock protein family (Hsp40) member B9 "GO:0002377,GO:0005515,GO:0005730,GO:0005737,GO:0005783,GO:0005788,GO:0005789,GO:0030183,GO:0030433,GO:0030544,GO:0034976,GO:0036498,GO:0051087,GO:0051787,GO:0070062,GO:1903895" immunoglobulin production|protein binding|nucleolus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|B cell differentiation|ubiquitin-dependent ERAD pathway|Hsp70 protein binding|response to endoplasmic reticulum stress|IRE1-mediated unfolded protein response|chaperone binding|misfolded protein binding|extracellular exosome|negative regulation of IRE1-mediated unfolded protein response DNAJC1 563.7444644 530.6110801 596.8778487 1.124887646 0.169780911 0.526567363 1 10.27121441 11.36062228 64215 DnaJ heat shock protein family (Hsp40) member C1 "GO:0001671,GO:0003677,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0006417,GO:0006457,GO:0016020,GO:0016021,GO:0031965,GO:0032781,GO:0045861,GO:0050708,GO:0051087" ATPase activator activity|DNA binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|regulation of translation|protein folding|membrane|integral component of membrane|nuclear membrane|positive regulation of ATPase activity|negative regulation of proteolysis|regulation of protein secretion|chaperone binding hsa04141 Protein processing in endoplasmic reticulum DNAJC10 5214.495166 5506.910681 4922.079651 0.893800524 -0.161975205 0.500750905 1 14.58963968 12.82201704 54431 DnaJ heat shock protein family (Hsp40) member C10 "GO:0001671,GO:0001933,GO:0005515,GO:0005783,GO:0005788,GO:0015035,GO:0015036,GO:0016020,GO:0016671,GO:0030433,GO:0030544,GO:0032781,GO:0034663,GO:0034975,GO:0034976,GO:0051087,GO:0051117,GO:0051787,GO:0055114,GO:0070059" "ATPase activator activity|negative regulation of protein phosphorylation|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|protein disulfide oxidoreductase activity|disulfide oxidoreductase activity|membrane|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|ubiquitin-dependent ERAD pathway|Hsp70 protein binding|positive regulation of ATPase activity|endoplasmic reticulum chaperone complex|protein folding in endoplasmic reticulum|response to endoplasmic reticulum stress|chaperone binding|ATPase binding|misfolded protein binding|oxidation-reduction process|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" hsa04141 Protein processing in endoplasmic reticulum DNAJC11 980.0703765 1064.343402 895.797351 0.841643166 -0.248719395 0.312933304 1 17.73401535 14.67595125 55735 DnaJ heat shock protein family (Hsp40) member C11 "GO:0001401,GO:0005515,GO:0005654,GO:0005739,GO:0007007,GO:0016607,GO:0042407,GO:0061617,GO:0140275" SAM complex|protein binding|nucleoplasm|mitochondrion|inner mitochondrial membrane organization|nuclear speck|cristae formation|MICOS complex|MIB complex DNAJC12 225.1570996 183.1128433 267.2013558 1.459216901 0.545194344 0.117069893 1 5.966053664 8.560087128 56521 DnaJ heat shock protein family (Hsp40) member C12 "GO:0005515,GO:0005737" protein binding|cytoplasm DNAJC13 2139.851765 2191.111637 2088.591892 0.953211081 -0.069132372 0.771485844 1 14.96679905 14.02778783 23317 DnaJ heat shock protein family (Hsp40) member C13 "GO:0001649,GO:0005515,GO:0005765,GO:0005829,GO:0005886,GO:0006898,GO:0007032,GO:0010008,GO:0015031,GO:0016020,GO:0030667,GO:0031901,GO:0035577,GO:0043231,GO:0043312,GO:0070062,GO:0071203,GO:1902954,GO:2000641" osteoblast differentiation|protein binding|lysosomal membrane|cytosol|plasma membrane|receptor-mediated endocytosis|endosome organization|endosome membrane|protein transport|membrane|secretory granule membrane|early endosome membrane|azurophil granule membrane|intracellular membrane-bounded organelle|neutrophil degranulation|extracellular exosome|WASH complex|regulation of early endosome to recycling endosome transport|regulation of early endosome to late endosome transport DNAJC14 1499.226113 1433.69033 1564.761896 1.091422508 0.126209702 0.598294178 1 23.49920698 25.21838618 85406 DnaJ heat shock protein family (Hsp40) member C14 "GO:0005789,GO:0015031,GO:0016020,GO:0016021" endoplasmic reticulum membrane|protein transport|membrane|integral component of membrane DNAJC15 269.8703588 234.0931236 305.647594 1.305666691 0.384786654 0.239639893 1 1.674905451 2.150273979 29103 DnaJ heat shock protein family (Hsp40) member C15 "GO:0001405,GO:0001671,GO:0005515,GO:0009267,GO:0016021,GO:0019216,GO:0030150,GO:0031333,GO:0032781,GO:1902957" "PAM complex, Tim23 associated import motor|ATPase activator activity|protein binding|cellular response to starvation|integral component of membrane|regulation of lipid metabolic process|protein import into mitochondrial matrix|negative regulation of protein-containing complex assembly|positive regulation of ATPase activity|negative regulation of mitochondrial electron transport, NADH to ubiquinone" DNAJC16 289.5042444 307.9625093 271.0459796 0.880126546 -0.184217123 0.56946211 1 2.723797333 2.357170999 23341 DnaJ heat shock protein family (Hsp40) member C16 GO:0016021 integral component of membrane DNAJC17 152.5703176 132.1325631 173.0080721 1.309352275 0.3888533 0.337789735 1 1.375667585 1.77109228 55192 DnaJ heat shock protein family (Hsp40) member C17 "GO:0000122,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:1901998" negative regulation of transcription by RNA polymerase II|RNA binding|protein binding|nucleus|cytoplasm|toxin transport DNAJC18 397.9607676 392.2360338 403.6855015 1.02919025 0.041509694 0.894806878 1 4.102884403 4.151988317 202052 DnaJ heat shock protein family (Hsp40) member C18 "GO:0005789,GO:0016021,GO:0030433,GO:0030544,GO:0051085,GO:0071218" endoplasmic reticulum membrane|integral component of membrane|ubiquitin-dependent ERAD pathway|Hsp70 protein binding|chaperone cofactor-dependent protein refolding|cellular response to misfolded protein DNAJC19 328.7480924 316.2858203 341.2103644 1.078803862 0.109432591 0.728159177 1 9.451059867 10.02522631 131118 DnaJ heat shock protein family (Hsp40) member C19 "GO:0001405,GO:0001671,GO:0005515,GO:0005739,GO:0005743,GO:0006457,GO:0006626,GO:0007601,GO:0016021,GO:0030150,GO:0032781,GO:0032991,GO:0048806,GO:0098800,GO:0099617,GO:1900208" "PAM complex, Tim23 associated import motor|ATPase activator activity|protein binding|mitochondrion|mitochondrial inner membrane|protein folding|protein targeting to mitochondrion|visual perception|integral component of membrane|protein import into mitochondrial matrix|positive regulation of ATPase activity|protein-containing complex|genitalia development|inner mitochondrial membrane protein complex|matrix side of mitochondrial inner membrane|regulation of cardiolipin metabolic process" DNAJC2 524.1684935 551.4193578 496.9176292 0.901161017 -0.150143189 0.582289125 1 12.70100892 11.25412659 27000 DnaJ heat shock protein family (Hsp40) member C2 "GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006260,GO:0006325,GO:0030544,GO:0031965,GO:0042393,GO:0045893,GO:0051083,GO:0061649,GO:1900034,GO:2000279" "chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|DNA replication|chromatin organization|Hsp70 protein binding|nuclear membrane|histone binding|positive regulation of transcription, DNA-templated|'de novo' cotranslational protein folding|ubiquitin modification-dependent histone binding|regulation of cellular response to heat|negative regulation of DNA biosynthetic process" DNAJC21 1230.351509 1213.122587 1247.580431 1.028404255 0.040407485 0.870425651 1 7.510687106 7.594771523 134218 DnaJ heat shock protein family (Hsp40) member C21 "GO:0003723,GO:0005515,GO:0005730,GO:0005829,GO:0005840,GO:0006457,GO:0008270" RNA binding|protein binding|nucleolus|cytosol|ribosome|protein folding|zinc ion binding DNAJC22 113.0194988 90.51600779 135.5229898 1.497226768 0.582292747 0.195198376 1 2.136520555 3.145327246 79962 DnaJ heat shock protein family (Hsp40) member C22 "GO:0005515,GO:0016021" protein binding|integral component of membrane DNAJC24 447.2571241 399.5189309 494.9953173 1.238978379 0.309151011 0.271808545 1 7.178986889 8.745770292 120526 DnaJ heat shock protein family (Hsp40) member C24 "GO:0001671,GO:0005737,GO:0005856,GO:0008198,GO:0008270,GO:0017183,GO:0032781,GO:0055114,GO:0061077" ATPase activator activity|cytoplasm|cytoskeleton|ferrous iron binding|zinc ion binding|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|positive regulation of ATPase activity|oxidation-reduction process|chaperone-mediated protein folding DNAJC25 173.4628836 163.3449796 183.5807876 1.123883869 0.168492969 0.670756632 1 3.823430414 4.225185755 548645 DnaJ heat shock protein family (Hsp40) member C25 "GO:0005789,GO:0006457,GO:0016021" endoplasmic reticulum membrane|protein folding|integral component of membrane DNAJC27 122.0957602 126.9304937 117.2610266 0.923820772 -0.11431511 0.809718654 1 1.334524657 1.212231329 51277 DnaJ heat shock protein family (Hsp40) member C27 "GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0006886,GO:0070374,GO:0071701" GTPase activity|protein binding|GTP binding|nucleus|intracellular protein transport|positive regulation of ERK1 and ERK2 cascade|regulation of MAPK export from nucleus DNAJC28 24.18238434 16.64662212 31.71814655 1.905380342 0.930079009 0.245386001 1 0.487863607 0.914010702 54943 DnaJ heat shock protein family (Hsp40) member C28 "GO:0005515,GO:0006890,GO:0007030,GO:0017119,GO:0048213" "protein binding|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|Golgi transport complex|Golgi vesicle prefusion complex stabilization" DNAJC3 1226.29868 1232.890451 1219.706908 0.989306801 -0.0155101 0.952483966 1 9.639188018 9.376540306 5611 DnaJ heat shock protein family (Hsp40) member C3 "GO:0004860,GO:0005576,GO:0005737,GO:0005783,GO:0005788,GO:0005790,GO:0005829,GO:0006469,GO:0016020,GO:0019901,GO:0034975,GO:0035578,GO:0036494,GO:0036498,GO:0043066,GO:0043312,GO:0043687,GO:0044267,GO:0051087,GO:0051603,GO:0051607,GO:0051787,GO:0070062,GO:0070417,GO:1903561,GO:1903912" protein kinase inhibitor activity|extracellular region|cytoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|smooth endoplasmic reticulum|cytosol|negative regulation of protein kinase activity|membrane|protein kinase binding|protein folding in endoplasmic reticulum|azurophil granule lumen|positive regulation of translation initiation in response to endoplasmic reticulum stress|IRE1-mediated unfolded protein response|negative regulation of apoptotic process|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|chaperone binding|proteolysis involved in cellular protein catabolic process|defense response to virus|misfolded protein binding|extracellular exosome|cellular response to cold|extracellular vesicle|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation "hsa04141,hsa05164" Protein processing in endoplasmic reticulum|Influenza A DNAJC30 164.4507889 166.4662212 162.4353566 0.97578569 -0.035363769 0.944761976 1 3.503153105 3.361125603 84277 DnaJ heat shock protein family (Hsp40) member C30 "GO:0005515,GO:0005743,GO:0006754,GO:0007420,GO:0016021,GO:1905706" protein binding|mitochondrial inner membrane|ATP biosynthetic process|brain development|integral component of membrane|regulation of mitochondrial ATP synthesis coupled proton transport DNAJC4 505.5750218 479.6307999 531.5192437 1.108184136 0.14819762 0.590616345 1 20.49400662 22.33109297 3338 DnaJ heat shock protein family (Hsp40) member C4 "GO:0005515,GO:0006457,GO:0006986,GO:0016020,GO:0016021,GO:0051082" protein binding|protein folding|response to unfolded protein|membrane|integral component of membrane|unfolded protein binding DNAJC5 3276.808214 3311.637388 3241.97904 0.978965587 -0.030669949 0.898290744 1 26.09419768 25.11785519 80331 DnaJ heat shock protein family (Hsp40) member C5 "GO:0005515,GO:0005739,GO:0005765,GO:0005794,GO:0005829,GO:0005886,GO:0006887,GO:0007269,GO:0016020,GO:0016079,GO:0031225,GO:0031594,GO:0035577,GO:0035579,GO:0042470,GO:0042584,GO:0043008,GO:0043231,GO:0043312,GO:0043524,GO:0045055,GO:0061077,GO:0061202,GO:0098693,GO:0098993" protein binding|mitochondrion|lysosomal membrane|Golgi apparatus|cytosol|plasma membrane|exocytosis|neurotransmitter secretion|membrane|synaptic vesicle exocytosis|anchored component of membrane|neuromuscular junction|azurophil granule membrane|specific granule membrane|melanosome|chromaffin granule membrane|ATP-dependent protein binding|intracellular membrane-bounded organelle|neutrophil degranulation|negative regulation of neuron apoptotic process|regulated exocytosis|chaperone-mediated protein folding|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|regulation of synaptic vesicle cycle|anchored component of synaptic vesicle membrane hsa04141 Protein processing in endoplasmic reticulum DNAJC6 254.9774719 221.608157 288.3467868 1.301156017 0.37979396 0.254898364 1 1.889570225 2.417483897 9829 DnaJ heat shock protein family (Hsp40) member C6 "GO:0004725,GO:0005737,GO:0005829,GO:0014069,GO:0016191,GO:0017124,GO:0030276,GO:0031982,GO:0035335,GO:0043231,GO:0061024,GO:0072318,GO:0072583,GO:0098793,GO:2000369" protein tyrosine phosphatase activity|cytoplasm|cytosol|postsynaptic density|synaptic vesicle uncoating|SH3 domain binding|clathrin binding|vesicle|peptidyl-tyrosine dephosphorylation|intracellular membrane-bounded organelle|membrane organization|clathrin coat disassembly|clathrin-dependent endocytosis|presynapse|regulation of clathrin-dependent endocytosis hsa04144 Endocytosis DNAJC7 1796.741668 1737.491184 1855.992151 1.068202341 0.095184952 0.689574666 1 42.53518859 44.67587497 7266 DnaJ heat shock protein family (Hsp40) member C7 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006457,GO:0016020,GO:0031072,GO:0051085,GO:0070062,GO:1900034" protein binding|nucleoplasm|cytoplasm|cytosol|cytoskeleton|protein folding|membrane|heat shock protein binding|chaperone cofactor-dependent protein refolding|extracellular exosome|regulation of cellular response to heat DNAJC8 1966.226564 1834.249675 2098.203452 1.143902861 0.193964546 0.412915451 1 55.52497672 62.45233923 22826 DnaJ heat shock protein family (Hsp40) member C8 "GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0030544,GO:0045171" "mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|cytosol|Hsp70 protein binding|intercellular bridge" DNAJC9 2208.871325 2249.374814 2168.367837 0.963986892 -0.052914565 0.82450876 1 52.3071894 49.57967688 23234 DnaJ heat shock protein family (Hsp40) member C9 "GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0031072,GO:0032781" protein binding|extracellular space|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|heat shock protein binding|positive regulation of ATPase activity DNAL1 346.4747573 352.7003062 340.2492084 0.964697797 -0.051851023 0.872652333 1 2.728361662 2.588000785 83544 dynein axonemal light chain 1 "GO:0003774,GO:0005515,GO:0005737,GO:0005874,GO:0036157,GO:0036158,GO:0043014,GO:0045504" motor activity|protein binding|cytoplasm|microtubule|outer dynein arm|outer dynein arm assembly|alpha-tubulin binding|dynein heavy chain binding "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNAL4 245.028759 263.2247123 226.8328056 0.861745858 -0.214665635 0.529764502 1 9.530406451 8.075358397 10126 dynein axonemal light chain 4 "GO:0003777,GO:0005515,GO:0005737,GO:0005874,GO:0005886,GO:0005929,GO:0007018,GO:0030286,GO:0042802,GO:0045505,GO:0051959,GO:2000582" "microtubule motor activity|protein binding|cytoplasm|microtubule|plasma membrane|cilium|microtubule-based movement|dynein complex|identical protein binding|dynein intermediate chain binding|dynein light intermediate chain binding|positive regulation of ATP-dependent microtubule motor activity, plus-end-directed" "hsa05014,hsa05016,hsa05022" Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases DNASE1 328.8374111 293.3967149 364.2781073 1.24158891 0.312187576 0.309060628 1 1.628332304 1.987888595 1773 deoxyribonuclease 1 "GO:0000737,GO:0002283,GO:0002673,GO:0003677,GO:0003779,GO:0004530,GO:0005515,GO:0005576,GO:0005634,GO:0005635,GO:0006308,GO:0006915,GO:0070062,GO:0070948" "DNA catabolic process, endonucleolytic|neutrophil activation involved in immune response|regulation of acute inflammatory response|DNA binding|actin binding|deoxyribonuclease I activity|protein binding|extracellular region|nucleus|nuclear envelope|DNA catabolic process|apoptotic process|extracellular exosome|regulation of neutrophil mediated cytotoxicity" DNASE1L1 1185.950251 1182.950585 1188.949918 1.005071499 0.007298136 0.979896987 1 16.22510885 16.03451231 1774 deoxyribonuclease 1 like 1 "GO:0000737,GO:0003677,GO:0004530,GO:0004536,GO:0005515,GO:0005576,GO:0005634,GO:0005783,GO:0006259,GO:0006308,GO:0035580,GO:0043312" "DNA catabolic process, endonucleolytic|DNA binding|deoxyribonuclease I activity|deoxyribonuclease activity|protein binding|extracellular region|nucleus|endoplasmic reticulum|DNA metabolic process|DNA catabolic process|specific granule lumen|neutrophil degranulation" DNASE1L2 12.68814183 17.687036 7.689247648 0.434739187 -1.201777951 0.253007279 1 0.699721723 0.299106137 1775 deoxyribonuclease 1 like 2 "GO:0000737,GO:0001942,GO:0003335,GO:0003677,GO:0004530,GO:0004536,GO:0005509,GO:0005576,GO:0005634,GO:0005737,GO:0006259,GO:0006308" "DNA catabolic process, endonucleolytic|hair follicle development|corneocyte development|DNA binding|deoxyribonuclease I activity|deoxyribonuclease activity|calcium ion binding|extracellular region|nucleus|cytoplasm|DNA metabolic process|DNA catabolic process" DNASE2 849.8249124 887.4730419 812.1767828 0.915156568 -0.12790951 0.611235307 1 24.43901194 21.99126555 1777 "deoxyribonuclease 2, lysosomal" "GO:0003677,GO:0004531,GO:0005764,GO:0006259,GO:0006309,GO:0030218,GO:0050776,GO:0070062" DNA binding|deoxyribonuclease II activity|lysosome|DNA metabolic process|apoptotic DNA fragmentation|erythrocyte differentiation|regulation of immune response|extracellular exosome hsa04142 Lysosome DND1 30.46449659 30.1720026 30.75699059 1.019388438 0.027703895 1 1 1.009545031 1.011897627 373863 DND microRNA-mediated repression inhibitor 1 "GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0007275,GO:0007281,GO:0035198,GO:0048255,GO:0060965,GO:0061158" RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|multicellular organism development|germ cell development|miRNA binding|mRNA stabilization|negative regulation of gene silencing by miRNA|3'-UTR-mediated mRNA destabilization DNER 2781.729107 2426.245174 3137.21304 1.293032161 0.370758159 0.117153882 1 40.08800177 50.96768575 92737 delta/notch like EGF repeat containing "GO:0001764,GO:0004888,GO:0005112,GO:0005509,GO:0005515,GO:0005769,GO:0005886,GO:0006897,GO:0007219,GO:0007220,GO:0007416,GO:0007417,GO:0010001,GO:0016021,GO:0030276,GO:0030425,GO:0043025,GO:0048741" neuron migration|transmembrane signaling receptor activity|Notch binding|calcium ion binding|protein binding|early endosome|plasma membrane|endocytosis|Notch signaling pathway|Notch receptor processing|synapse assembly|central nervous system development|glial cell differentiation|integral component of membrane|clathrin binding|dendrite|neuronal cell body|skeletal muscle fiber development DNHD1 164.2771818 199.7594655 128.7948981 0.644749914 -0.63318842 0.105939772 1 0.679680939 0.430891138 144132 dynein heavy chain domain 1 "GO:0003341,GO:0005524,GO:0007018,GO:0008569,GO:0030286,GO:0036156,GO:0045505,GO:0051959,GO:0070062" "cilium movement|ATP binding|microtubule-based movement|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|inner dynein arm|dynein intermediate chain binding|dynein light intermediate chain binding|extracellular exosome" DNLZ 157.8912739 145.6579436 170.1246042 1.167973404 0.224007423 0.58189688 1 2.510819361 2.883497645 728489 DNL-type zinc finger "GO:0005654,GO:0005739,GO:0006457,GO:0008270,GO:0030150,GO:0050821,GO:0051087" nucleoplasm|mitochondrion|protein folding|zinc ion binding|protein import into mitochondrial matrix|protein stabilization|chaperone binding DNM1 2045.35151 2157.818393 1932.884628 0.895758714 -0.158817922 0.502582277 1 28.51877209 25.11846192 1759 dynamin 1 "GO:0000266,GO:0003374,GO:0003723,GO:0003924,GO:0005515,GO:0005525,GO:0005654,GO:0005737,GO:0005874,GO:0005886,GO:0006897,GO:0006898,GO:0007032,GO:0008017,GO:0014069,GO:0015630,GO:0016020,GO:0016185,GO:0019901,GO:0030424,GO:0031410,GO:0031623,GO:0031966,GO:0042802,GO:0044327,GO:0048013,GO:0048285,GO:0050803,GO:0061025,GO:0070062,GO:0098793,GO:0098844,GO:0098884" mitochondrial fission|dynamin family protein polymerization involved in mitochondrial fission|RNA binding|GTPase activity|protein binding|GTP binding|nucleoplasm|cytoplasm|microtubule|plasma membrane|endocytosis|receptor-mediated endocytosis|endosome organization|microtubule binding|postsynaptic density|microtubule cytoskeleton|membrane|synaptic vesicle budding from presynaptic endocytic zone membrane|protein kinase binding|axon|cytoplasmic vesicle|receptor internalization|mitochondrial membrane|identical protein binding|dendritic spine head|ephrin receptor signaling pathway|organelle fission|regulation of synapse structure or activity|membrane fusion|extracellular exosome|presynapse|postsynaptic endocytic zone membrane|postsynaptic neurotransmitter receptor internalization "hsa04072,hsa04144,hsa04721,hsa04961,hsa05100" Phospholipase D signaling pathway|Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Bacterial invasion of epithelial cells DNM1L 2955.997204 2976.624118 2935.37029 0.986140733 -0.020134545 0.933681244 1 35.65812758 34.57551129 10059 dynamin 1 like "GO:0000139,GO:0000266,GO:0001836,GO:0003374,GO:0003924,GO:0005096,GO:0005515,GO:0005525,GO:0005737,GO:0005739,GO:0005741,GO:0005777,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005874,GO:0005903,GO:0005905,GO:0006816,GO:0007005,GO:0007029,GO:0008017,GO:0008289,GO:0010468,GO:0010637,GO:0010821,GO:0016020,GO:0016559,GO:0030276,GO:0030672,GO:0030742,GO:0031267,GO:0031625,GO:0031966,GO:0032991,GO:0036466,GO:0042802,GO:0042803,GO:0043065,GO:0043231,GO:0043547,GO:0043653,GO:0044877,GO:0048285,GO:0048312,GO:0048471,GO:0048488,GO:0048511,GO:0050714,GO:0051259,GO:0051433,GO:0060047,GO:0061003,GO:0061025,GO:0065003,GO:0070266,GO:0070584,GO:0070585,GO:0090023,GO:0090141,GO:0090149,GO:0090200,GO:0090650,GO:0097194,GO:0098835,GO:0099073,GO:1900063,GO:1900244,GO:1903146,GO:1903578,GO:1904579,GO:1904666,GO:1905395,GO:1990910,GO:2000302,GO:2001244" Golgi membrane|mitochondrial fission|release of cytochrome c from mitochondria|dynamin family protein polymerization involved in mitochondrial fission|GTPase activity|GTPase activator activity|protein binding|GTP binding|cytoplasm|mitochondrion|mitochondrial outer membrane|peroxisome|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|microtubule|brush border|clathrin-coated pit|calcium ion transport|mitochondrion organization|endoplasmic reticulum organization|microtubule binding|lipid binding|regulation of gene expression|negative regulation of mitochondrial fusion|regulation of mitochondrion organization|membrane|peroxisome fission|clathrin binding|synaptic vesicle membrane|GTP-dependent protein binding|small GTPase binding|ubiquitin protein ligase binding|mitochondrial membrane|protein-containing complex|synaptic vesicle recycling via endosome|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of GTPase activity|mitochondrial fragmentation involved in apoptotic process|protein-containing complex binding|organelle fission|intracellular distribution of mitochondria|perinuclear region of cytoplasm|synaptic vesicle endocytosis|rhythmic process|positive regulation of protein secretion|protein complex oligomerization|BH2 domain binding|heart contraction|positive regulation of dendritic spine morphogenesis|membrane fusion|protein-containing complex assembly|necroptotic process|mitochondrion morphogenesis|protein localization to mitochondrion|positive regulation of neutrophil chemotaxis|positive regulation of mitochondrial fission|mitochondrial membrane fission|positive regulation of release of cytochrome c from mitochondria|cellular response to oxygen-glucose deprivation|execution phase of apoptosis|presynaptic endocytic zone membrane|mitochondrion-derived vesicle|regulation of peroxisome organization|positive regulation of synaptic vesicle endocytosis|regulation of autophagy of mitochondrion|regulation of ATP metabolic process|cellular response to thapsigargin|regulation of ubiquitin protein ligase activity|response to flavonoid|response to hypobaric hypoxia|positive regulation of synaptic vesicle exocytosis|positive regulation of intrinsic apoptotic signaling pathway "hsa04217,hsa04621,hsa04668" Necroptosis|NOD-like receptor signaling pathway|TNF signaling pathway DNM2 2370.666974 2346.133305 2395.200642 1.02091413 0.029861525 0.901229307 1 33.19427956 33.32143073 1785 dynamin 2 "GO:0000086,GO:0000139,GO:0000266,GO:0001891,GO:0002031,GO:0003374,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005768,GO:0005794,GO:0005802,GO:0005813,GO:0005829,GO:0005874,GO:0005886,GO:0005905,GO:0005925,GO:0006355,GO:0006893,GO:0006897,GO:0006898,GO:0006909,GO:0007165,GO:0007283,GO:0008017,GO:0009416,GO:0010592,GO:0014069,GO:0015630,GO:0016020,GO:0016185,GO:0017124,GO:0019886,GO:0019899,GO:0019901,GO:0030027,GO:0030424,GO:0030426,GO:0030496,GO:0030512,GO:0030516,GO:0030666,GO:0030670,GO:0031410,GO:0031623,GO:0031749,GO:0031966,GO:0032587,GO:0032991,GO:0033572,GO:0035020,GO:0036312,GO:0042220,GO:0043065,GO:0044327,GO:0044351,GO:0044877,GO:0045211,GO:0045334,GO:0045429,GO:0045893,GO:0048285,GO:0048471,GO:0048489,GO:0048812,GO:0050699,GO:0050766,GO:0050803,GO:0050998,GO:0050999,GO:0061024,GO:0061025,GO:0070062,GO:0071245,GO:0071481,GO:0071732,GO:0098793,GO:0098844,GO:0098884,GO:0098978,GO:0099092,GO:1900026,GO:1902856,GO:1903351,GO:1903358,GO:1903408,GO:1903526,GO:2000370" "G2/M transition of mitotic cell cycle|Golgi membrane|mitochondrial fission|phagocytic cup|G protein-coupled receptor internalization|dynamin family protein polymerization involved in mitochondrial fission|GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|endosome|Golgi apparatus|trans-Golgi network|centrosome|cytosol|microtubule|plasma membrane|clathrin-coated pit|focal adhesion|regulation of transcription, DNA-templated|Golgi to plasma membrane transport|endocytosis|receptor-mediated endocytosis|phagocytosis|signal transduction|spermatogenesis|microtubule binding|response to light stimulus|positive regulation of lamellipodium assembly|postsynaptic density|microtubule cytoskeleton|membrane|synaptic vesicle budding from presynaptic endocytic zone membrane|SH3 domain binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|enzyme binding|protein kinase binding|lamellipodium|axon|growth cone|midbody|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of axon extension|endocytic vesicle membrane|phagocytic vesicle membrane|cytoplasmic vesicle|receptor internalization|D2 dopamine receptor binding|mitochondrial membrane|ruffle membrane|protein-containing complex|transferrin transport|regulation of Rac protein signal transduction|phosphatidylinositol 3-kinase regulatory subunit binding|response to cocaine|positive regulation of apoptotic process|dendritic spine head|macropinocytosis|protein-containing complex binding|postsynaptic membrane|clathrin-coated endocytic vesicle|positive regulation of nitric oxide biosynthetic process|positive regulation of transcription, DNA-templated|organelle fission|perinuclear region of cytoplasm|synaptic vesicle transport|neuron projection morphogenesis|WW domain binding|positive regulation of phagocytosis|regulation of synapse structure or activity|nitric-oxide synthase binding|regulation of nitric-oxide synthase activity|membrane organization|membrane fusion|extracellular exosome|cellular response to carbon monoxide|cellular response to X-ray|cellular response to nitric oxide|presynapse|postsynaptic endocytic zone membrane|postsynaptic neurotransmitter receptor internalization|glutamatergic synapse|postsynaptic density, intracellular component|positive regulation of substrate adhesion-dependent cell spreading|negative regulation of non-motile cilium assembly|cellular response to dopamine|regulation of Golgi organization|positive regulation of sodium:potassium-exchanging ATPase activity|negative regulation of membrane tubulation|positive regulation of clathrin-dependent endocytosis" "hsa04072,hsa04144,hsa04666,hsa04721,hsa04961,hsa05100,hsa05132" Phospholipase D signaling pathway|Endocytosis|Fc gamma R-mediated phagocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Bacterial invasion of epithelial cells|Salmonella infection DNM3 36.23143233 30.1720026 42.29086206 1.401659102 0.487135514 0.486508203 1 0.130150689 0.179374231 26052 dynamin 3 "GO:0000266,GO:0003374,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005794,GO:0005874,GO:0005886,GO:0006897,GO:0007416,GO:0008017,GO:0014069,GO:0015630,GO:0016020,GO:0016185,GO:0030424,GO:0031410,GO:0031623,GO:0031798,GO:0031802,GO:0031966,GO:0043083,GO:0043197,GO:0044327,GO:0046847,GO:0048285,GO:0048471,GO:0050803,GO:0050998,GO:0051491,GO:0061002,GO:0061025,GO:0061828,GO:0061829,GO:0070062,GO:0098793,GO:0098844,GO:0098884,GO:0098978,GO:0099173,GO:0099186,GO:1903423" mitochondrial fission|dynamin family protein polymerization involved in mitochondrial fission|GTPase activity|protein binding|GTP binding|cytoplasm|Golgi apparatus|microtubule|plasma membrane|endocytosis|synapse assembly|microtubule binding|postsynaptic density|microtubule cytoskeleton|membrane|synaptic vesicle budding from presynaptic endocytic zone membrane|axon|cytoplasmic vesicle|receptor internalization|type 1 metabotropic glutamate receptor binding|type 5 metabotropic glutamate receptor binding|mitochondrial membrane|synaptic cleft|dendritic spine|dendritic spine head|filopodium assembly|organelle fission|perinuclear region of cytoplasm|regulation of synapse structure or activity|nitric-oxide synthase binding|positive regulation of filopodium assembly|negative regulation of dendritic spine morphogenesis|membrane fusion|apical tubulobulbar complex|basal tubulobulbar complex|extracellular exosome|presynapse|postsynaptic endocytic zone membrane|postsynaptic neurotransmitter receptor internalization|glutamatergic synapse|postsynapse organization|structural constituent of postsynapse|positive regulation of synaptic vesicle recycling "hsa04072,hsa04144,hsa04721,hsa04961,hsa05100" Phospholipase D signaling pathway|Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Bacterial invasion of epithelial cells DNMBP 4885.856514 5117.795889 4653.917139 0.909359662 -0.137077086 0.567832964 1 34.32541919 30.69182503 23268 dynamin binding protein "GO:0005085,GO:0005515,GO:0005794,GO:0005795,GO:0005856,GO:0005911,GO:0007568,GO:0008360,GO:0035556,GO:0045202,GO:0050790,GO:0098793" guanyl-nucleotide exchange factor activity|protein binding|Golgi apparatus|Golgi stack|cytoskeleton|cell-cell junction|aging|regulation of cell shape|intracellular signal transduction|synapse|regulation of catalytic activity|presynapse DNMT1 2924.818772 3028.644812 2820.992731 0.931437295 -0.102469446 0.665786454 1 30.59496635 28.02042909 1786 DNA methyltransferase 1 "GO:0000122,GO:0003677,GO:0003886,GO:0005515,GO:0005634,GO:0005654,GO:0006306,GO:0006325,GO:0007265,GO:0008270,GO:0009008,GO:0010216,GO:0010628,GO:0010629,GO:0045814,GO:0051571,GO:0051573,GO:0090116,GO:0090309,GO:1904707,GO:1905460,GO:1905931,GO:1990841" "negative regulation of transcription by RNA polymerase II|DNA binding|DNA (cytosine-5-)-methyltransferase activity|protein binding|nucleus|nucleoplasm|DNA methylation|chromatin organization|Ras protein signal transduction|zinc ion binding|DNA-methyltransferase activity|maintenance of DNA methylation|positive regulation of gene expression|negative regulation of gene expression|negative regulation of gene expression, epigenetic|positive regulation of histone H3-K4 methylation|negative regulation of histone H3-K9 methylation|C-5 methylation of cytosine|positive regulation of DNA methylation-dependent heterochromatin assembly|positive regulation of vascular associated smooth muscle cell proliferation|negative regulation of vascular associated smooth muscle cell apoptotic process|negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching|promoter-specific chromatin binding" "hsa00270,hsa05206" Cysteine and methionine metabolism|MicroRNAs in cancer DNMT3A 304.4317299 333.9728563 274.8906034 0.82309265 -0.28087326 0.371937196 1 1.47387063 1.19283196 1788 DNA methyltransferase 3 alpha "GO:0000122,GO:0000278,GO:0000775,GO:0000791,GO:0000792,GO:0000978,GO:0001741,GO:0003677,GO:0003682,GO:0003714,GO:0003886,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006306,GO:0006346,GO:0006349,GO:0007283,GO:0007568,GO:0008134,GO:0009008,GO:0009636,GO:0010212,GO:0010288,GO:0010942,GO:0016363,GO:0030182,GO:0032355,GO:0033189,GO:0042220,GO:0042493,GO:0042802,GO:0043045,GO:0043046,GO:0045814,GO:0046872,GO:0071230,GO:0071361,GO:0071456,GO:0090116,GO:0097284" "negative regulation of transcription by RNA polymerase II|mitotic cell cycle|chromosome, centromeric region|euchromatin|heterochromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|XY body|DNA binding|chromatin binding|transcription corepressor activity|DNA (cytosine-5-)-methyltransferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|DNA methylation|DNA methylation-dependent heterochromatin assembly|regulation of gene expression by genetic imprinting|spermatogenesis|aging|transcription factor binding|DNA-methyltransferase activity|response to toxic substance|response to ionizing radiation|response to lead ion|positive regulation of cell death|nuclear matrix|neuron differentiation|response to estradiol|response to vitamin A|response to cocaine|response to drug|identical protein binding|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|negative regulation of gene expression, epigenetic|metal ion binding|cellular response to amino acid stimulus|cellular response to ethanol|cellular response to hypoxia|C-5 methylation of cytosine|hepatocyte apoptotic process" "hsa00270,hsa05206" Cysteine and methionine metabolism|MicroRNAs in cancer DNMT3B 807.7265503 1006.080225 609.3728761 0.605690144 -0.723348159 0.004073063 0.390726074 11.5966852 6.906460837 1789 DNA methyltransferase 3 beta "GO:0000122,GO:0001666,GO:0003677,GO:0003682,GO:0003714,GO:0003886,GO:0005515,GO:0005634,GO:0005654,GO:0006306,GO:0009008,GO:0009636,GO:0010212,GO:0010628,GO:0014823,GO:0031000,GO:0032355,GO:0033189,GO:0042220,GO:0042493,GO:0042826,GO:0045666,GO:0045814,GO:0046872,GO:0051571,GO:0051573,GO:0071455,GO:0071549,GO:0090116" "negative regulation of transcription by RNA polymerase II|response to hypoxia|DNA binding|chromatin binding|transcription corepressor activity|DNA (cytosine-5-)-methyltransferase activity|protein binding|nucleus|nucleoplasm|DNA methylation|DNA-methyltransferase activity|response to toxic substance|response to ionizing radiation|positive regulation of gene expression|response to activity|response to caffeine|response to estradiol|response to vitamin A|response to cocaine|response to drug|histone deacetylase binding|positive regulation of neuron differentiation|negative regulation of gene expression, epigenetic|metal ion binding|positive regulation of histone H3-K4 methylation|negative regulation of histone H3-K9 methylation|cellular response to hyperoxia|cellular response to dexamethasone stimulus|C-5 methylation of cytosine" "hsa00270,hsa05206" Cysteine and methionine metabolism|MicroRNAs in cancer DNPEP 908.3560461 935.3320805 881.3800116 0.942317739 -0.085714492 0.732992568 1 11.54149227 10.69376191 23549 aspartyl aminopeptidase "GO:0004177,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0008237,GO:0008270,GO:0042802,GO:0072562" aminopeptidase activity|protein binding|nucleus|cytoplasm|cytosol|proteolysis|peptide metabolic process|metallopeptidase activity|zinc ion binding|identical protein binding|blood microparticle DNPH1 199.5229205 191.4361544 207.6096865 1.084485254 0.117010436 0.758849838 1 12.69142325 13.53334513 10591 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 "GO:0005515,GO:0005634,GO:0005829,GO:0006195,GO:0009116,GO:0009159,GO:0030307,GO:0030855,GO:0042802,GO:0042803,GO:0070062,GO:0070694" protein binding|nucleus|cytosol|purine nucleotide catabolic process|nucleoside metabolic process|deoxyribonucleoside monophosphate catabolic process|positive regulation of cell growth|epithelial cell differentiation|identical protein binding|protein homodimerization activity|extracellular exosome|deoxyribonucleoside 5'-monophosphate N-glycosidase activity DNTTIP1 1812.616446 1599.116138 2026.116755 1.267022893 0.341442592 0.149836947 1 63.12269912 78.63958294 116092 deoxynucleotidyltransferase terminal interacting protein 1 "GO:0000118,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0031491,GO:0042803" histone deacetylase complex|DNA binding|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|nucleosome binding|protein homodimerization activity DNTTIP2 1733.31605 1611.601104 1855.030995 1.151048476 0.202948593 0.392933526 1 14.58754901 16.51000181 30836 deoxynucleotidyltransferase terminal interacting protein 2 "GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730" RNA binding|protein binding|nucleoplasm|chromosome|nucleolus DOC2A 69.4108201 81.15228285 57.66935736 0.710631363 -0.492826733 0.359529788 1 1.131682306 0.790751592 8448 double C2 domain alpha "GO:0005509,GO:0005515,GO:0005544,GO:0005654,GO:0005730,GO:0005764,GO:0007268,GO:0007399,GO:0016079,GO:0017158,GO:0030054,GO:0043005,GO:0061669,GO:0098850" calcium ion binding|protein binding|calcium-dependent phospholipid binding|nucleoplasm|nucleolus|lysosome|chemical synaptic transmission|nervous system development|synaptic vesicle exocytosis|regulation of calcium ion-dependent exocytosis|cell junction|neuron projection|spontaneous neurotransmitter secretion|extrinsic component of synaptic vesicle membrane DOCK1 1578.10887 1662.581384 1493.636356 0.898383904 -0.154596014 0.517068786 1 7.402095002 6.538645553 1793 dedicator of cytokinesis 1 "GO:0005085,GO:0005096,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006911,GO:0006915,GO:0007165,GO:0007229,GO:0007264,GO:0007596,GO:0010634,GO:0016020,GO:0016607,GO:0017124,GO:0032045,GO:0038096,GO:0043547,GO:0048010,GO:1900026" "guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|nucleoplasm|cytoplasm|cytosol|phagocytosis, engulfment|apoptotic process|signal transduction|integrin-mediated signaling pathway|small GTPase mediated signal transduction|blood coagulation|positive regulation of epithelial cell migration|membrane|nuclear speck|SH3 domain binding|guanyl-nucleotide exchange factor complex|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of GTPase activity|vascular endothelial growth factor receptor signaling pathway|positive regulation of substrate adhesion-dependent cell spreading" "hsa04510,hsa04666,hsa04810,hsa05100,hsa05131,hsa05135" Focal adhesion|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Shigellosis|Yersinia infection DOCK10 909.4260281 963.4232553 855.4288008 0.887905493 -0.171521967 0.490800775 1 5.104351081 4.456341448 55619 dedicator of cytokinesis 10 "GO:0001782,GO:0002315,GO:0003674,GO:0005085,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007264,GO:0016020,GO:0030334,GO:0043197,GO:0043547,GO:0060997,GO:0070062" B cell homeostasis|marginal zone B cell differentiation|molecular_function|guanyl-nucleotide exchange factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|small GTPase mediated signal transduction|membrane|regulation of cell migration|dendritic spine|positive regulation of GTPase activity|dendritic spine morphogenesis|extracellular exosome DOCK11 685.8893 734.5322011 637.2463988 0.867554068 -0.204974423 0.426600683 1 5.345055026 4.559528235 139818 dedicator of cytokinesis 11 "GO:0001782,GO:0002315,GO:0005085,GO:0005515,GO:0005829,GO:0007264,GO:0007596,GO:0043547,GO:0051491" B cell homeostasis|marginal zone B cell differentiation|guanyl-nucleotide exchange factor activity|protein binding|cytosol|small GTPase mediated signal transduction|blood coagulation|positive regulation of GTPase activity|positive regulation of filopodium assembly DOCK2 91.68598378 60.34400519 123.0279624 2.038776876 1.027703895 0.033932041 0.93741548 0.238551752 0.478215323 1794 dedicator of cytokinesis 2 "GO:0001766,GO:0001768,GO:0001771,GO:0002277,GO:0005085,GO:0005096,GO:0005515,GO:0005576,GO:0005829,GO:0005856,GO:0006935,GO:0007264,GO:0016020,GO:0030036,GO:0035580,GO:0042608,GO:0043312,GO:0043547,GO:0044351,GO:0045059,GO:0045060,GO:0046633,GO:0050690,GO:0050766,GO:0070062" membrane raft polarization|establishment of T cell polarity|immunological synapse formation|myeloid dendritic cell activation involved in immune response|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|extracellular region|cytosol|cytoskeleton|chemotaxis|small GTPase mediated signal transduction|membrane|actin cytoskeleton organization|specific granule lumen|T cell receptor binding|neutrophil degranulation|positive regulation of GTPase activity|macropinocytosis|positive thymic T cell selection|negative thymic T cell selection|alpha-beta T cell proliferation|regulation of defense response to virus by virus|positive regulation of phagocytosis|extracellular exosome hsa04062 Chemokine signaling pathway DOCK3 16.21070353 21.84869154 10.57271552 0.483906119 -1.047200914 0.266820442 1 0.073100402 0.0347818 1795 dedicator of cytokinesis 3 "GO:0005085,GO:0005515,GO:0005829,GO:0007264,GO:0017124,GO:1903997" guanyl-nucleotide exchange factor activity|protein binding|cytosol|small GTPase mediated signal transduction|SH3 domain binding|positive regulation of non-membrane spanning protein tyrosine kinase activity DOCK4 2006.336604 1978.867205 2033.806003 1.027762751 0.039507271 0.869370828 1 11.24571459 11.36452032 9732 dedicator of cytokinesis 4 "GO:0005085,GO:0005096,GO:0005515,GO:0005730,GO:0005794,GO:0005829,GO:0005886,GO:0007264,GO:0016020,GO:0017124,GO:0030165,GO:0030971,GO:0031267,GO:0032420,GO:0032421,GO:0043547,GO:0060326,GO:1904694,GO:1904754" guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|nucleolus|Golgi apparatus|cytosol|plasma membrane|small GTPase mediated signal transduction|membrane|SH3 domain binding|PDZ domain binding|receptor tyrosine kinase binding|small GTPase binding|stereocilium|stereocilium bundle|positive regulation of GTPase activity|cell chemotaxis|negative regulation of vascular associated smooth muscle contraction|positive regulation of vascular associated smooth muscle cell migration hsa04015 Rap1 signaling pathway DOCK5 1713.903618 1783.269395 1644.537841 0.922203816 -0.11684246 0.623860888 1 8.912699953 8.081786618 80005 dedicator of cytokinesis 5 "GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007264,GO:0010634,GO:0016477,GO:0043547,GO:1900026,GO:1904694,GO:1904754" guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytoplasm|cytosol|plasma membrane|small GTPase mediated signal transduction|positive regulation of epithelial cell migration|cell migration|positive regulation of GTPase activity|positive regulation of substrate adhesion-dependent cell spreading|negative regulation of vascular associated smooth muscle contraction|positive regulation of vascular associated smooth muscle cell migration DOCK6 753.2293532 786.5528953 719.905811 0.915266876 -0.127735626 0.617332269 1 6.176704296 5.558731974 57572 dedicator of cytokinesis 6 "GO:0005085,GO:0005515,GO:0005829,GO:0007264,GO:0007596,GO:0048471,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|cytosol|small GTPase mediated signal transduction|blood coagulation|perinuclear region of cytoplasm|regulation of catalytic activity DOCK7 2315.172179 2415.841035 2214.503323 0.91665937 -0.125542365 0.596114902 1 14.89131392 13.42184379 85440 dedicator of cytokinesis 7 "GO:0000226,GO:0005085,GO:0005515,GO:0005925,GO:0007264,GO:0007409,GO:0008180,GO:0022027,GO:0030424,GO:0030426,GO:0031175,GO:0031267,GO:0033138,GO:0043005,GO:0045178,GO:0045200,GO:0050767,GO:0090630,GO:0120163,GO:1904754" microtubule cytoskeleton organization|guanyl-nucleotide exchange factor activity|protein binding|focal adhesion|small GTPase mediated signal transduction|axonogenesis|COP9 signalosome|interkinetic nuclear migration|axon|growth cone|neuron projection development|small GTPase binding|positive regulation of peptidyl-serine phosphorylation|neuron projection|basal part of cell|establishment of neuroblast polarity|regulation of neurogenesis|activation of GTPase activity|negative regulation of cold-induced thermogenesis|positive regulation of vascular associated smooth muscle cell migration DOCK8 35.54767912 37.45489978 33.64045846 0.898159084 -0.154957094 0.858559181 1 0.243857407 0.215357696 81704 dedicator of cytokinesis 8 "GO:0001771,GO:0005085,GO:0005515,GO:0005737,GO:0005829,GO:0007264,GO:0007596,GO:0016020,GO:0031256,GO:0031258,GO:0036336,GO:0043547,GO:0061485,GO:0070233,GO:1903905,GO:1990869,GO:2000406" immunological synapse formation|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|cytosol|small GTPase mediated signal transduction|blood coagulation|membrane|leading edge membrane|lamellipodium membrane|dendritic cell migration|positive regulation of GTPase activity|memory T cell proliferation|negative regulation of T cell apoptotic process|positive regulation of establishment of T cell polarity|cellular response to chemokine|positive regulation of T cell migration DOCK9 2893.689415 3157.656134 2629.722696 0.832808445 -0.263943396 0.264707418 1 18.72841791 15.33618684 23348 dedicator of cytokinesis 9 "GO:0005085,GO:0005515,GO:0005829,GO:0007264,GO:0007596,GO:0008150,GO:0012505,GO:0016020,GO:0043547,GO:0045296" guanyl-nucleotide exchange factor activity|protein binding|cytosol|small GTPase mediated signal transduction|blood coagulation|biological_process|endomembrane system|membrane|positive regulation of GTPase activity|cadherin binding DOHH 170.7725301 181.0320156 160.5130447 0.886655568 -0.173554313 0.662833595 1 4.510432282 3.932278704 83475 deoxyhypusine hydroxylase "GO:0005506,GO:0005515,GO:0005575,GO:0005829,GO:0008612,GO:0016491,GO:0018215,GO:0019135,GO:0055114" iron ion binding|protein binding|cellular_component|cytosol|peptidyl-lysine modification to peptidyl-hypusine|oxidoreductase activity|protein phosphopantetheinylation|deoxyhypusine monooxygenase activity|oxidation-reduction process DOK1 556.3225587 562.8639105 549.7812068 0.976756897 -0.033928557 0.905730155 1 12.08813376 11.60959106 1796 docking protein 1 "GO:0005515,GO:0005634,GO:0005829,GO:0007165,GO:0007166,GO:0007169,GO:0007265,GO:0007411,GO:0038145,GO:0045742,GO:0048471" protein binding|nucleus|cytosol|signal transduction|cell surface receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|Ras protein signal transduction|axon guidance|macrophage colony-stimulating factor signaling pathway|positive regulation of epidermal growth factor receptor signaling pathway|perinuclear region of cytoplasm DOK3 7.56533034 9.363724944 5.766935736 0.615880514 -0.699277611 0.654804973 1 0.120299661 0.072850417 79930 docking protein 3 "GO:0005515,GO:0005886,GO:0030667,GO:0043312,GO:0101003" protein binding|plasma membrane|secretory granule membrane|neutrophil degranulation|ficolin-1-rich granule membrane DOK4 383.1968285 357.9023756 408.4912813 1.141348337 0.190739166 0.518426255 1 6.181421356 6.937096522 55715 docking protein 4 "GO:0005515,GO:0005829,GO:0007411" protein binding|cytosol|axon guidance DOK7 20.41701844 18.72744989 22.10658699 1.180437653 0.239321845 0.82900801 1 0.183519938 0.213008771 285489 docking protein 7 "GO:0005515,GO:0005654,GO:0005739,GO:0005886,GO:0007528,GO:0008289,GO:0019901,GO:0045202,GO:0061098" protein binding|nucleoplasm|mitochondrion|plasma membrane|neuromuscular junction development|lipid binding|protein kinase binding|synapse|positive regulation of protein tyrosine kinase activity DOLK 283.7769377 309.0029231 258.5509522 0.836726558 -0.257171868 0.426652136 1 7.951262336 6.541702876 22845 dolichol kinase "GO:0004168,GO:0005515,GO:0005789,GO:0006489,GO:0016310,GO:0030176,GO:0043048" dolichol kinase activity|protein binding|endoplasmic reticulum membrane|dolichyl diphosphate biosynthetic process|phosphorylation|integral component of endoplasmic reticulum membrane|dolichyl monophosphate biosynthetic process hsa00510 N-Glycan biosynthesis DOLPP1 430.7784643 446.3375557 415.219373 0.930281057 -0.104261445 0.719077551 1 10.98211849 10.04549823 57171 dolichyldiphosphatase 1 "GO:0005789,GO:0006487,GO:0006489,GO:0008610,GO:0030176,GO:0043231,GO:0047874" endoplasmic reticulum membrane|protein N-linked glycosylation|dolichyl diphosphate biosynthetic process|lipid biosynthetic process|integral component of endoplasmic reticulum membrane|intracellular membrane-bounded organelle|dolichyldiphosphatase activity hsa00510 N-Glycan biosynthesis DONSON 1111.506553 969.6657386 1253.347367 1.292556101 0.3702269 0.128619246 1 20.69971132 26.30782046 29980 DNA replication fork stabilization factor DONSON "GO:0000077,GO:0005515,GO:0005634,GO:0005657,GO:0006260,GO:0007095,GO:0007275,GO:0030894,GO:0033260,GO:0048478" DNA damage checkpoint|protein binding|nucleus|replication fork|DNA replication|mitotic G2 DNA damage checkpoint|multicellular organism development|replisome|nuclear DNA replication|replication fork protection DOP1A 309.4356545 339.1749257 279.6963832 0.82463756 -0.278167921 0.374174048 1 1.833027079 1.486288684 23033 DOP1 leucine zipper like protein A "GO:0000139,GO:0005768,GO:0005802,GO:0005829,GO:0006895,GO:0015031" Golgi membrane|endosome|trans-Golgi network|cytosol|Golgi to endosome transport|protein transport DOP1B 400.7001965 451.5396251 349.860768 0.774817421 -0.368071702 0.20301953 1 3.087487495 2.352208218 9980 DOP1 leucine zipper like protein B "GO:0000139,GO:0003674,GO:0005768,GO:0005802,GO:0005829,GO:0006895,GO:0007029,GO:0007275,GO:0015031,GO:0050890,GO:0070062" Golgi membrane|molecular_function|endosome|trans-Golgi network|cytosol|Golgi to endosome transport|endoplasmic reticulum organization|multicellular organism development|protein transport|cognition|extracellular exosome DOT1L 741.5319354 794.8762063 688.1876645 0.865779676 -0.207928161 0.414469828 1 4.233218462 3.60370512 84444 DOT1 like histone lysine methyltransferase "GO:0000077,GO:0000781,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006348,GO:0008284,GO:0010467,GO:0018024,GO:0031151,GO:0032200,GO:0032991,GO:0034729,GO:0042054,GO:0043231,GO:0045944,GO:0046425,GO:2000677" "DNA damage checkpoint|chromosome, telomeric region|DNA binding|protein binding|nucleus|nucleoplasm|DNA repair|chromatin silencing at telomere|positive regulation of cell population proliferation|gene expression|histone-lysine N-methyltransferase activity|histone methyltransferase activity (H3-K79 specific)|telomere organization|protein-containing complex|histone H3-K79 methylation|histone methyltransferase activity|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|regulation of receptor signaling pathway via JAK-STAT|regulation of transcription regulatory region DNA binding" "hsa00310,hsa05202" Lysine degradation|Transcriptional misregulation in cancer DPAGT1 958.5682848 1054.979677 862.1568925 0.817226067 -0.291192872 0.238139403 1 29.35470615 23.58800042 1798 dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 "GO:0003975,GO:0003976,GO:0005515,GO:0005789,GO:0006047,GO:0006487,GO:0006488,GO:0006489,GO:0008963,GO:0016020,GO:0016021,GO:0016757,GO:0019348,GO:0030176,GO:0042802,GO:0043231,GO:0046872" "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity|protein binding|endoplasmic reticulum membrane|UDP-N-acetylglucosamine metabolic process|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|dolichyl diphosphate biosynthetic process|phospho-N-acetylmuramoyl-pentapeptide-transferase activity|membrane|integral component of membrane|transferase activity, transferring glycosyl groups|dolichol metabolic process|integral component of endoplasmic reticulum membrane|identical protein binding|intracellular membrane-bounded organelle|metal ion binding" hsa00510 N-Glycan biosynthesis DPCD 685.067767 586.7934298 783.3421041 1.334953775 0.416789787 0.104952537 1 13.34302806 17.51426053 25911 deleted in primary ciliary dyskinesia homolog (mouse) "GO:0003351,GO:0005515,GO:0005576,GO:0005634,GO:0007283,GO:0007368,GO:0021670,GO:0021678,GO:0030317,GO:0060972" epithelial cilium movement involved in extracellular fluid movement|protein binding|extracellular region|nucleus|spermatogenesis|determination of left/right symmetry|lateral ventricle development|third ventricle development|flagellated sperm motility|left/right pattern formation DPF1 159.5066149 112.3646993 206.6485305 1.839087647 0.878990238 0.027003567 0.873268385 2.379641859 4.303137324 8193 double PHD fingers 1 "GO:0003712,GO:0005737,GO:0006915,GO:0007399,GO:0008270,GO:0042393,GO:0045892,GO:0045944,GO:0071565,GO:1990837" "transcription coregulator activity|cytoplasm|apoptotic process|nervous system development|zinc ion binding|histone binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|nBAF complex|sequence-specific double-stranded DNA binding" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma other DPF2 1673.560834 1619.924415 1727.197253 1.066220891 0.092506355 0.698660762 1 32.33073626 33.89486908 5977 double PHD fingers 2 "GO:0000122,GO:0000785,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0006325,GO:0006915,GO:0007399,GO:0042393,GO:0043231,GO:0045892,GO:0045944,GO:0046872,GO:0062072,GO:0070577,GO:0071565,GO:0097190,GO:1905454" "negative regulation of transcription by RNA polymerase II|chromatin|transcription coregulator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|centrosome|cytosol|chromatin organization|apoptotic process|nervous system development|histone binding|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|H3K9me3 modified histone binding|lysine-acetylated histone binding|nBAF complex|apoptotic signaling pathway|negative regulation of myeloid progenitor cell differentiation" DPF3 404.9165723 423.4484502 386.3846943 0.912471622 -0.132148403 0.651968089 1 1.483728286 1.331204943 8110 double PHD fingers 3 "GO:0003712,GO:0005654,GO:0006325,GO:0007399,GO:0008150,GO:0008270,GO:0042393,GO:0045892,GO:0045944,GO:0071565" "transcription coregulator activity|nucleoplasm|chromatin organization|nervous system development|biological_process|zinc ion binding|histone binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|nBAF complex" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma DPH1 316.3518301 369.3469283 263.3567319 0.713033497 -0.487958241 0.114656123 1 7.335826846 5.143161752 1801 diphthamide biosynthesis 1 "GO:0005515,GO:0005654,GO:0005829,GO:0016740,GO:0017183,GO:0030054" protein binding|nucleoplasm|cytosol|transferase activity|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|cell junction DPH2 348.4020996 340.2153396 356.5888597 1.048126931 0.067813441 0.830354644 1 7.151109644 7.369847399 1802 diphthamide biosynthesis 2 "GO:0005515,GO:0005829,GO:0017183,GO:0090560" protein binding|cytosol|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|2-(3-amino-3-carboxypropyl)histidine synthase activity DPH3 642.7026774 572.2276355 713.1777193 1.246318205 0.317672458 0.22165009 1 7.598590991 9.311790269 285381 diphthamide biosynthesis 3 "GO:0002098,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0017183,GO:0046872,GO:0050709,GO:0051099" tRNA wobble uridine modification|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|metal ion binding|negative regulation of protein secretion|positive regulation of binding DPH5 839.1679085 897.8771807 780.4586363 0.869226497 -0.202195942 0.420189788 1 2.954986119 2.525570989 51611 diphthamide biosynthesis 5 "GO:0004164,GO:0005575,GO:0005829,GO:0017183,GO:0032259" diphthine synthase activity|cellular_component|cytosol|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|methylation DPH6 177.5452812 169.5874629 185.5030995 1.093849135 0.129413773 0.745367466 1 0.90750739 0.976065082 89978 diphthamine biosynthesis 6 "GO:0005524,GO:0005654,GO:0005730,GO:0005829,GO:0017178,GO:0017183" ATP binding|nucleoplasm|nucleolus|cytosol|diphthine-ammonia ligase activity|peptidyl-diphthamide biosynthetic process from peptidyl-histidine DPH7 423.4804759 469.2266611 377.7342907 0.805014553 -0.312913231 0.272539206 1 8.386391326 6.638195425 92715 diphthamide biosynthesis 7 "GO:0005515,GO:0017183,GO:0061685" protein binding|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|diphthine methylesterase activity DPM1 1425.198212 1281.789903 1568.60652 1.223762581 0.291323691 0.223538598 1 58.26811867 70.11312819 8813 "dolichyl-phosphate mannosyltransferase subunit 1, catalytic" "GO:0004169,GO:0004582,GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0006506,GO:0016020,GO:0018279,GO:0019348,GO:0033185,GO:0035268,GO:0035269" dolichyl-phosphate-mannose-protein mannosyltransferase activity|dolichyl-phosphate beta-D-mannosyltransferase activity|protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|GPI anchor biosynthetic process|membrane|protein N-linked glycosylation via asparagine|dolichol metabolic process|dolichol-phosphate-mannose synthase complex|protein mannosylation|protein O-linked mannosylation hsa00510 N-Glycan biosynthesis DPM2 1304.553632 1230.809623 1378.297641 1.119830082 0.16327984 0.498491183 1 46.71838368 51.44120311 8818 "dolichyl-phosphate mannosyltransferase subunit 2, regulatory" "GO:0000506,GO:0004582,GO:0005515,GO:0005789,GO:0006506,GO:0008047,GO:0016254,GO:0018279,GO:0019348,GO:0030176,GO:0030234,GO:0031647,GO:0033185,GO:0035269,GO:0050790" glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|dolichyl-phosphate beta-D-mannosyltransferase activity|protein binding|endoplasmic reticulum membrane|GPI anchor biosynthetic process|enzyme activator activity|preassembly of GPI anchor in ER membrane|protein N-linked glycosylation via asparagine|dolichol metabolic process|integral component of endoplasmic reticulum membrane|enzyme regulator activity|regulation of protein stability|dolichol-phosphate-mannose synthase complex|protein O-linked mannosylation|regulation of catalytic activity "hsa00510,hsa00563" N-Glycan biosynthesis|Glycosylphosphatidylinositol (GPI)-anchor biosynthesis DPM3 158.7385734 130.0517353 187.4254114 1.441160404 0.527230919 0.185080436 1 12.43839084 17.62575378 54344 "dolichyl-phosphate mannosyltransferase subunit 3, regulatory" "GO:0004582,GO:0005515,GO:0005783,GO:0005789,GO:0005975,GO:0006506,GO:0008047,GO:0016020,GO:0018279,GO:0018406,GO:0030176,GO:0031501,GO:0031647,GO:0033185,GO:0035268,GO:0035269,GO:0050790" dolichyl-phosphate beta-D-mannosyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|carbohydrate metabolic process|GPI anchor biosynthetic process|enzyme activator activity|membrane|protein N-linked glycosylation via asparagine|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan|integral component of endoplasmic reticulum membrane|mannosyltransferase complex|regulation of protein stability|dolichol-phosphate-mannose synthase complex|protein mannosylation|protein O-linked mannosylation|regulation of catalytic activity hsa00510 N-Glycan biosynthesis DPP3 754.6163669 822.9673812 686.2653526 0.833891316 -0.26206873 0.30173933 1 16.51137466 13.53829153 10072 dipeptidyl peptidase 3 "GO:0005515,GO:0005737,GO:0005829,GO:0006508,GO:0008239,GO:0008270,GO:0070006,GO:0070062" protein binding|cytoplasm|cytosol|proteolysis|dipeptidyl-peptidase activity|zinc ion binding|metalloaminopeptidase activity|extracellular exosome DPP4 54.03735523 68.66731625 39.4073942 0.573888661 -0.801157225 0.169735147 1 1.025650284 0.578759493 1803 dipeptidyl peptidase 4 "GO:0001618,GO:0001662,GO:0001666,GO:0002020,GO:0004177,GO:0004252,GO:0005102,GO:0005515,GO:0005576,GO:0005765,GO:0005886,GO:0005925,GO:0006508,GO:0007155,GO:0008236,GO:0008239,GO:0008284,GO:0009986,GO:0010716,GO:0016020,GO:0016021,GO:0016324,GO:0030027,GO:0030139,GO:0031258,GO:0031295,GO:0033632,GO:0035641,GO:0036343,GO:0042110,GO:0042802,GO:0042803,GO:0043542,GO:0045121,GO:0045499,GO:0046581,GO:0046718,GO:0050796,GO:0050919,GO:0070062,GO:0071438,GO:0090024" virus receptor activity|behavioral fear response|response to hypoxia|protease binding|aminopeptidase activity|serine-type endopeptidase activity|signaling receptor binding|protein binding|extracellular region|lysosomal membrane|plasma membrane|focal adhesion|proteolysis|cell adhesion|serine-type peptidase activity|dipeptidyl-peptidase activity|positive regulation of cell population proliferation|cell surface|negative regulation of extracellular matrix disassembly|membrane|integral component of membrane|apical plasma membrane|lamellipodium|endocytic vesicle|lamellipodium membrane|T cell costimulation|regulation of cell-cell adhesion mediated by integrin|locomotory exploration behavior|psychomotor behavior|T cell activation|identical protein binding|protein homodimerization activity|endothelial cell migration|membrane raft|chemorepellent activity|intercellular canaliculus|viral entry into host cell|regulation of insulin secretion|negative chemotaxis|extracellular exosome|invadopodium membrane|negative regulation of neutrophil chemotaxis hsa04974 Protein digestion and absorption DPP7 1065.325179 1182.950585 947.6997726 0.801132173 -0.319887812 0.190677422 1 37.82618246 29.79667918 29952 dipeptidyl peptidase 7 "GO:0004177,GO:0005576,GO:0005794,GO:0005829,GO:0006508,GO:0008236,GO:0008239,GO:0031982,GO:0035578,GO:0043231,GO:0043312,GO:0070062" aminopeptidase activity|extracellular region|Golgi apparatus|cytosol|proteolysis|serine-type peptidase activity|dipeptidyl-peptidase activity|vesicle|azurophil granule lumen|intracellular membrane-bounded organelle|neutrophil degranulation|extracellular exosome DPP8 973.9323032 991.5144302 956.3501762 0.964534804 -0.052094798 0.836333332 1 6.699835757 6.354088187 54878 dipeptidyl peptidase 8 "GO:0004177,GO:0005737,GO:0005829,GO:0006508,GO:0006915,GO:0006955,GO:0008236,GO:0008239" aminopeptidase activity|cytoplasm|cytosol|proteolysis|apoptotic process|immune response|serine-type peptidase activity|dipeptidyl-peptidase activity DPP9 2061.320638 1984.069274 2138.572002 1.07787164 0.108185383 0.648526511 1 18.40537643 19.50666061 91039 dipeptidyl peptidase 9 "GO:0004177,GO:0005634,GO:0005829,GO:0005874,GO:0006508,GO:0008236,GO:0008239,GO:0031252,GO:0042802" aminopeptidase activity|nucleus|cytosol|microtubule|proteolysis|serine-type peptidase activity|dipeptidyl-peptidase activity|cell leading edge|identical protein binding DPY19L1 2170.634522 2027.766657 2313.502386 1.140911543 0.190186941 0.421550253 1 20.65626639 23.17261139 23333 dpy-19 like C-mannosyltransferase 1 "GO:0000030,GO:0005637,GO:0016020,GO:0016021,GO:0018406" mannosyltransferase activity|nuclear inner membrane|membrane|integral component of membrane|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan DPY19L2 57.48568942 58.26317743 56.7082014 0.97331117 -0.039026983 0.979599862 1 0.415417327 0.397564405 283417 dpy-19 like 2 "GO:0000030,GO:0005634,GO:0005637,GO:0007275,GO:0007286,GO:0016021,GO:0018406" mannosyltransferase activity|nucleus|nuclear inner membrane|multicellular organism development|spermatid development|integral component of membrane|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan DPY19L3 612.3067635 670.0265404 554.5869866 0.827708983 -0.272804479 0.298312046 1 5.806769244 4.725887894 147991 dpy-19 like C-mannosyltransferase 3 "GO:0000030,GO:0005637,GO:0016021,GO:0018406" mannosyltransferase activity|nuclear inner membrane|integral component of membrane|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan DPY19L4 1385.373792 1422.245778 1348.501806 0.948149629 -0.076813344 0.750832702 1 16.26369042 15.16237232 286148 dpy-19 like 4 "GO:0000030,GO:0005637,GO:0016021,GO:0018406" mannosyltransferase activity|nuclear inner membrane|integral component of membrane|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan DPY30 764.4964971 653.3799183 875.6130759 1.34012854 0.422371385 0.095152883 1 11.6000284 15.28539575 84661 dpy-30 histone methyltransferase complex regulatory subunit "GO:0000781,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0005802,GO:0006348,GO:0016197,GO:0035097,GO:0042802,GO:0042803,GO:0044666,GO:0045652,GO:0048188,GO:0051568" "chromosome, telomeric region|protein binding|nucleus|nucleoplasm|Golgi apparatus|trans-Golgi network|chromatin silencing at telomere|endosomal transport|histone methyltransferase complex|identical protein binding|protein homodimerization activity|MLL3/4 complex|regulation of megakaryocyte differentiation|Set1C/COMPASS complex|histone H3-K4 methylation" DPYD 883.1583999 854.1797976 912.1370022 1.067851294 0.094710755 0.706683579 1 5.380149402 5.649061368 1806 dihydropyrimidine dehydrogenase "GO:0002058,GO:0005515,GO:0005737,GO:0005829,GO:0006145,GO:0006208,GO:0006210,GO:0006212,GO:0006214,GO:0017113,GO:0019483,GO:0042803,GO:0046050,GO:0046079,GO:0046135,GO:0046872,GO:0050660,GO:0050661,GO:0051536,GO:0051539,GO:0055114" "uracil binding|protein binding|cytoplasm|cytosol|purine nucleobase catabolic process|pyrimidine nucleobase catabolic process|thymine catabolic process|uracil catabolic process|thymidine catabolic process|dihydropyrimidine dehydrogenase (NADP+) activity|beta-alanine biosynthetic process|protein homodimerization activity|UMP catabolic process|dUMP catabolic process|pyrimidine nucleoside catabolic process|metal ion binding|flavin adenine dinucleotide binding|NADP binding|iron-sulfur cluster binding|4 iron, 4 sulfur cluster binding|oxidation-reduction process" "hsa00240,hsa00410,hsa00770,hsa00983" Pyrimidine metabolism|beta-Alanine metabolism|Pantothenate and CoA biosynthesis|Drug metabolism - other enzymes DPYSL2 1001.414567 968.6253247 1034.203809 1.067702632 0.094509895 0.703420973 1 9.79790624 10.28619542 1808 dihydropyrimidinase like 2 "GO:0004157,GO:0005515,GO:0005829,GO:0005874,GO:0005886,GO:0006139,GO:0006208,GO:0006897,GO:0007010,GO:0007165,GO:0007399,GO:0007411,GO:0007420,GO:0008017,GO:0016020,GO:0030516,GO:0042802,GO:0045664,GO:0070062" dihydropyrimidinase activity|protein binding|cytosol|microtubule|plasma membrane|nucleobase-containing compound metabolic process|pyrimidine nucleobase catabolic process|endocytosis|cytoskeleton organization|signal transduction|nervous system development|axon guidance|brain development|microtubule binding|membrane|regulation of axon extension|identical protein binding|regulation of neuron differentiation|extracellular exosome hsa04360 Axon guidance DPYSL3 4030.22688 3926.521993 4133.931767 1.052822771 0.074262598 0.755917912 1 34.78029247 36.0047399 1809 dihydropyrimidinase like 3 "GO:0004157,GO:0005515,GO:0005615,GO:0005829,GO:0006208,GO:0010976,GO:0010977,GO:0017124,GO:0030027,GO:0030336,GO:0030426,GO:0031005,GO:0031941,GO:0035374,GO:0042802,GO:0044297,GO:0045202,GO:0048666,GO:0048678,GO:0051017,GO:0051491,GO:0051764,GO:0070382,GO:0071345" dihydropyrimidinase activity|protein binding|extracellular space|cytosol|pyrimidine nucleobase catabolic process|positive regulation of neuron projection development|negative regulation of neuron projection development|SH3 domain binding|lamellipodium|negative regulation of cell migration|growth cone|filamin binding|filamentous actin|chondroitin sulfate binding|identical protein binding|cell body|synapse|neuron development|response to axon injury|actin filament bundle assembly|positive regulation of filopodium assembly|actin crosslink formation|exocytic vesicle|cellular response to cytokine stimulus DQX1 2.923096831 1.040413883 4.80577978 4.619103859 2.207612985 0.416510993 1 0.021748914 0.098779421 165545 DEAQ-box RNA dependent ATPase 1 "GO:0003678,GO:0003723,GO:0005524,GO:0005622,GO:0005681,GO:0032508" DNA helicase activity|RNA binding|ATP binding|intracellular anatomical structure|spliceosomal complex|DNA duplex unwinding DR1 2002.650496 1983.02886 2022.272131 1.019789561 0.028271475 0.907011918 1 10.45343793 10.48192108 1810 down-regulator of transcription 1 "GO:0000122,GO:0001046,GO:0003713,GO:0003714,GO:0005515,GO:0005654,GO:0005671,GO:0006338,GO:0016251,GO:0017025,GO:0017054,GO:0043966,GO:0045944,GO:0046982,GO:0051123,GO:0090575" negative regulation of transcription by RNA polymerase II|core promoter sequence-specific DNA binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling|RNA polymerase II general transcription initiation factor activity|TBP-class protein binding|negative cofactor 2 complex|histone H3 acetylation|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|RNA polymerase II preinitiation complex assembly|RNA polymerase II transcription regulator complex DRAM1 1770.706783 1646.975176 1894.438389 1.150253153 0.201951411 0.394976997 1 24.05474498 27.20604223 55332 DNA damage regulated autophagy modulator 1 "GO:0005515,GO:0005737,GO:0005764,GO:0005765,GO:0006914,GO:0006915,GO:0010506,GO:0016021" protein binding|cytoplasm|lysosome|lysosomal membrane|autophagy|apoptotic process|regulation of autophagy|integral component of membrane DRAM2 1051.379585 1006.080225 1096.678946 1.09005119 0.124395887 0.613380385 1 23.40568984 25.08646786 128338 DNA damage regulated autophagy modulator 2 "GO:0001917,GO:0005737,GO:0005764,GO:0005765,GO:0005794,GO:0006914,GO:0006915,GO:0007601,GO:0010506,GO:0016021,GO:0016324,GO:0043231,GO:0045494" photoreceptor inner segment|cytoplasm|lysosome|lysosomal membrane|Golgi apparatus|autophagy|apoptotic process|visual perception|regulation of autophagy|integral component of membrane|apical plasma membrane|intracellular membrane-bounded organelle|photoreceptor cell maintenance DRAP1 5135.344952 4450.89059 5819.799314 1.307558385 0.386875368 0.107676238 1 288.973054 371.5263463 10589 DR1 associated protein 1 "GO:0000122,GO:0001046,GO:0001091,GO:0003677,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0006355,GO:0006366,GO:0016251,GO:0017025,GO:0017054,GO:0042802,GO:0045944,GO:0046982,GO:0090575" "negative regulation of transcription by RNA polymerase II|core promoter sequence-specific DNA binding|RNA polymerase II general transcription initiation factor binding|DNA binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|regulation of transcription, DNA-templated|transcription by RNA polymerase II|RNA polymerase II general transcription initiation factor activity|TBP-class protein binding|negative cofactor 2 complex|identical protein binding|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|RNA polymerase II transcription regulator complex" NF-YB/C DRC1 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.06692444 0.10131935 92749 dynein regulatory complex subunit 1 "GO:0003352,GO:0005829,GO:0005858,GO:0005930,GO:0007368,GO:0007507,GO:0031514,GO:0060285,GO:0070286" regulation of cilium movement|cytosol|axonemal dynein complex|axoneme|determination of left/right symmetry|heart development|motile cilium|cilium-dependent cell motility|axonemal dynein complex assembly DRC3 11.76661483 18.72744989 4.80577978 0.256616881 -1.962312016 0.074840402 1 0.238077556 0.060072383 83450 dynein regulatory complex subunit 3 "GO:0005515,GO:0005737,GO:0005930,GO:0031514" protein binding|cytoplasm|axoneme|motile cilium DRD4 7.966650391 7.282897178 8.650403604 1.187769564 0.248254969 0.952730603 1 0.277823329 0.324468157 1815 dopamine receptor D4 "GO:0000187,GO:0001591,GO:0001662,GO:0001963,GO:0001975,GO:0004952,GO:0004993,GO:0005515,GO:0005886,GO:0005887,GO:0006874,GO:0007186,GO:0007187,GO:0007195,GO:0007212,GO:0007268,GO:0008344,GO:0015459,GO:0016020,GO:0017124,GO:0030425,GO:0030594,GO:0032417,GO:0033674,GO:0034776,GO:0035176,GO:0035240,GO:0042053,GO:0042417,GO:0042596,GO:0042752,GO:0042802,GO:0046872,GO:0048148,GO:0048149,GO:0048511,GO:0050482,GO:0050709,GO:0051379,GO:0051380,GO:0051586,GO:0060080,GO:0098664,GO:0098794,GO:0098978,GO:0099149,GO:1901386" "activation of MAPK activity|dopamine neurotransmitter receptor activity, coupled via Gi/Go|behavioral fear response|synaptic transmission, dopaminergic|response to amphetamine|dopamine neurotransmitter receptor activity|G protein-coupled serotonin receptor activity|protein binding|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting dopamine receptor signaling pathway|dopamine receptor signaling pathway|chemical synaptic transmission|adult locomotory behavior|potassium channel regulator activity|membrane|SH3 domain binding|dendrite|neurotransmitter receptor activity|positive regulation of sodium:proton antiporter activity|positive regulation of kinase activity|response to histamine|social behavior|dopamine binding|regulation of dopamine metabolic process|dopamine metabolic process|fear response|regulation of circadian rhythm|identical protein binding|metal ion binding|behavioral response to cocaine|behavioral response to ethanol|rhythmic process|arachidonic acid secretion|negative regulation of protein secretion|epinephrine binding|norepinephrine binding|positive regulation of dopamine uptake involved in synaptic transmission|inhibitory postsynaptic potential|G protein-coupled serotonin receptor signaling pathway|postsynapse|glutamatergic synapse|regulation of postsynaptic neurotransmitter receptor internalization|negative regulation of voltage-gated calcium channel activity" "hsa04080,hsa04728" Neuroactive ligand-receptor interaction|Dopaminergic synapse DRG1 1794.670901 1708.359595 1880.982206 1.101045828 0.138874519 0.559056915 1 54.75796503 59.28214025 4733 developmentally regulated GTP binding protein 1 "GO:0002181,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0006351,GO:0007275,GO:0008017,GO:0008134,GO:0016020,GO:0016604,GO:0030955,GO:0031116,GO:0042802,GO:1901673" "cytoplasmic translation|GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|cytosol|polysome|transcription, DNA-templated|multicellular organism development|microtubule binding|transcription factor binding|membrane|nuclear body|potassium ion binding|positive regulation of microtubule polymerization|identical protein binding|regulation of mitotic spindle assembly" DRG2 630.6133861 658.5819877 602.6447844 0.915064177 -0.128055167 0.626631645 1 17.20377399 15.47912691 1819 developmentally regulated GTP binding protein 2 "GO:0002181,GO:0003723,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0016020,GO:0043231,GO:0046872" cytoplasmic translation|RNA binding|GTPase activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|cytosol|signal transduction|membrane|intracellular membrane-bounded organelle|metal ion binding DROSHA 1765.528637 1775.986498 1755.070776 0.98822304 -0.017091403 0.94510114 1 15.32931186 14.89528487 29102 drosha ribonuclease III "GO:0001530,GO:0003723,GO:0003725,GO:0004525,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006396,GO:0010586,GO:0010628,GO:0014069,GO:0016075,GO:0017151,GO:0030422,GO:0031053,GO:0031054,GO:0042254,GO:0042803,GO:0045589,GO:0046332,GO:0046872,GO:0050727,GO:0050829,GO:0050830,GO:0070412,GO:0070877,GO:0070878,GO:0090502,GO:2000628" "lipopolysaccharide binding|RNA binding|double-stranded RNA binding|ribonuclease III activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|RNA processing|miRNA metabolic process|positive regulation of gene expression|postsynaptic density|rRNA catabolic process|DEAD/H-box RNA helicase binding|production of siRNA involved in RNA interference|primary miRNA processing|pre-miRNA processing|ribosome biogenesis|protein homodimerization activity|regulation of regulatory T cell differentiation|SMAD binding|metal ion binding|regulation of inflammatory response|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|R-SMAD binding|microprocessor complex|primary miRNA binding|RNA phosphodiester bond hydrolysis, endonucleolytic|regulation of miRNA metabolic process" "hsa03008,hsa05205" Ribosome biogenesis in eukaryotes|Proteoglycans in cancer DRP2 69.24727383 89.47559391 49.01895376 0.547847202 -0.868154523 0.103197834 1 0.656197334 0.353480197 1821 dystrophin related protein 2 "GO:0005886,GO:0007417,GO:0008270,GO:0014069,GO:0030425,GO:0043204,GO:0050808,GO:0098978,GO:0099536" plasma membrane|central nervous system development|zinc ion binding|postsynaptic density|dendrite|perikaryon|synapse organization|glutamatergic synapse|synaptic signaling DSC2 534.3203817 502.5199053 566.1208581 1.126564047 0.171929335 0.526184995 1 2.161392952 2.394202041 1824 desmocollin 2 "GO:0001533,GO:0005509,GO:0005515,GO:0005886,GO:0005911,GO:0005912,GO:0007155,GO:0007156,GO:0009267,GO:0014704,GO:0016021,GO:0030057,GO:0031410,GO:0031424,GO:0070062,GO:0070268,GO:0086042,GO:0086073,GO:0086083,GO:0086091,GO:0098609,GO:0098911" cornified envelope|calcium ion binding|protein binding|plasma membrane|cell-cell junction|adherens junction|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cellular response to starvation|intercalated disc|integral component of membrane|desmosome|cytoplasmic vesicle|keratinization|extracellular exosome|cornification|cardiac muscle cell-cardiac muscle cell adhesion|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|regulation of heart rate by cardiac conduction|cell-cell adhesion|regulation of ventricular cardiac muscle cell action potential hsa05412 Arrhythmogenic right ventricular cardiomyopathy DSC3 2382.517877 2354.456616 2410.579138 1.023836719 0.033985654 0.887381682 1 16.47692399 16.58738855 1825 desmocollin 3 "GO:0001533,GO:0001701,GO:0005509,GO:0005576,GO:0005737,GO:0005886,GO:0005911,GO:0007155,GO:0007156,GO:0016020,GO:0016021,GO:0030054,GO:0030057,GO:0031424,GO:0045295,GO:0070268,GO:0098609" cornified envelope|in utero embryonic development|calcium ion binding|extracellular region|cytoplasm|plasma membrane|cell-cell junction|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|membrane|integral component of membrane|cell junction|desmosome|keratinization|gamma-catenin binding|cornification|cell-cell adhesion DSCAM 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.017622911 1826 DS cell adhesion molecule "GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0007155,GO:0007156,GO:0007162,GO:0007399,GO:0007411,GO:0007416,GO:0007626,GO:0010842,GO:0016020,GO:0030424,GO:0030425,GO:0030426,GO:0038007,GO:0042327,GO:0043025,GO:0045202,GO:0048813,GO:0048842,GO:0060060,GO:0060219,GO:0070593,GO:0098632,GO:1990782,GO:1990890" protein binding|extracellular region|plasma membrane|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|negative regulation of cell adhesion|nervous system development|axon guidance|synapse assembly|locomotory behavior|retina layer formation|membrane|axon|dendrite|growth cone|netrin-activated signaling pathway|positive regulation of phosphorylation|neuronal cell body|synapse|dendrite morphogenesis|positive regulation of axon extension involved in axon guidance|post-embryonic retina morphogenesis in camera-type eye|camera-type eye photoreceptor cell differentiation|dendrite self-avoidance|cell-cell adhesion mediator activity|protein tyrosine kinase binding|netrin receptor binding DSCC1 456.1648088 456.7416945 455.5879231 0.997473908 -0.003648991 0.998597345 1 11.00969502 10.79811658 79075 DNA replication and sister chromatid cohesion 1 "GO:0000775,GO:0000785,GO:0003689,GO:0005515,GO:0005634,GO:0005654,GO:0006260,GO:0006275,GO:0017116,GO:0031390,GO:0032508,GO:0034088,GO:0034421,GO:1900264" "chromosome, centromeric region|chromatin|DNA clamp loader activity|protein binding|nucleus|nucleoplasm|DNA replication|regulation of DNA replication|single-stranded DNA helicase activity|Ctf18 RFC-like complex|DNA duplex unwinding|maintenance of mitotic sister chromatid cohesion|post-translational protein acetylation|positive regulation of DNA-directed DNA polymerase activity" DSE 1577.379843 1782.228981 1372.530705 0.770120293 -0.376844282 0.113483989 1 15.49344928 11.73215685 29940 dermatan sulfate epimerase "GO:0000139,GO:0005783,GO:0005794,GO:0015012,GO:0016021,GO:0030204,GO:0030205,GO:0030206,GO:0030208,GO:0047757" Golgi membrane|endoplasmic reticulum|Golgi apparatus|heparan sulfate proteoglycan biosynthetic process|integral component of membrane|chondroitin sulfate metabolic process|dermatan sulfate metabolic process|chondroitin sulfate biosynthetic process|dermatan sulfate biosynthetic process|chondroitin-glucuronate 5-epimerase activity hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate DSEL 679.1316402 708.5218541 649.7414263 0.917037947 -0.124946662 0.630690863 1 4.08078018 3.679609121 92126 dermatan sulfate epimerase like "GO:0000139,GO:0008146,GO:0016021,GO:0030204,GO:0030205,GO:0030208,GO:0047757" Golgi membrane|sulfotransferase activity|integral component of membrane|chondroitin sulfate metabolic process|dermatan sulfate metabolic process|dermatan sulfate biosynthetic process|chondroitin-glucuronate 5-epimerase activity DSG2 6292.668231 6509.869664 6075.466798 0.933270113 -0.099633399 0.681860851 1 82.19062676 75.42248358 1829 desmoglein 2 "GO:0001533,GO:0002934,GO:0003165,GO:0005509,GO:0005886,GO:0005911,GO:0007155,GO:0007156,GO:0009986,GO:0014704,GO:0016021,GO:0016324,GO:0016328,GO:0030054,GO:0030057,GO:0031424,GO:0032570,GO:0043231,GO:0050839,GO:0060135,GO:0070062,GO:0070268,GO:0086073,GO:0086083,GO:0086091,GO:0098609,GO:0098911" cornified envelope|desmosome organization|Purkinje myocyte development|calcium ion binding|plasma membrane|cell-cell junction|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell surface|intercalated disc|integral component of membrane|apical plasma membrane|lateral plasma membrane|cell junction|desmosome|keratinization|response to progesterone|intracellular membrane-bounded organelle|cell adhesion molecule binding|maternal process involved in female pregnancy|extracellular exosome|cornification|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|regulation of heart rate by cardiac conduction|cell-cell adhesion|regulation of ventricular cardiac muscle cell action potential hsa05412 Arrhythmogenic right ventricular cardiomyopathy DSN1 1444.693089 1402.477914 1486.908264 1.060200841 0.08433759 0.726350484 1 30.42588155 31.71775888 79980 DSN1 component of MIS12 kinetochore complex "GO:0000070,GO:0000444,GO:0000776,GO:0000777,GO:0000818,GO:0000941,GO:0001650,GO:0005515,GO:0005576,GO:0005654,GO:0005730,GO:0005829,GO:0016604,GO:0035578,GO:0043312,GO:0051301" mitotic sister chromatid segregation|MIS12/MIND type complex|kinetochore|condensed chromosome kinetochore|nuclear MIS12/MIND complex|condensed nuclear chromosome inner kinetochore|fibrillar center|protein binding|extracellular region|nucleoplasm|nucleolus|cytosol|nuclear body|azurophil granule lumen|neutrophil degranulation|cell division DSP 2930.286954 3273.142075 2587.431834 0.790503979 -0.339155371 0.15189652 1 22.11159199 17.18680901 1832 desmoplakin "GO:0001533,GO:0002934,GO:0003223,GO:0003723,GO:0005080,GO:0005198,GO:0005200,GO:0005515,GO:0005634,GO:0005737,GO:0005882,GO:0005886,GO:0005916,GO:0008544,GO:0014704,GO:0016020,GO:0016323,GO:0018149,GO:0030057,GO:0030216,GO:0031424,GO:0034332,GO:0042060,GO:0043312,GO:0043588,GO:0045104,GO:0045109,GO:0070062,GO:0070268,GO:0086073,GO:0086083,GO:0086091,GO:0090136,GO:0097110,GO:0098609,GO:0098911,GO:0101003,GO:0150105" cornified envelope|desmosome organization|ventricular compact myocardium morphogenesis|RNA binding|protein kinase C binding|structural molecule activity|structural constituent of cytoskeleton|protein binding|nucleus|cytoplasm|intermediate filament|plasma membrane|fascia adherens|epidermis development|intercalated disc|membrane|basolateral plasma membrane|peptide cross-linking|desmosome|keratinocyte differentiation|keratinization|adherens junction organization|wound healing|neutrophil degranulation|skin development|intermediate filament cytoskeleton organization|intermediate filament organization|extracellular exosome|cornification|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|regulation of heart rate by cardiac conduction|epithelial cell-cell adhesion|scaffold protein binding|cell-cell adhesion|regulation of ventricular cardiac muscle cell action potential|ficolin-1-rich granule membrane|protein localization to cell-cell junction hsa05412 Arrhythmogenic right ventricular cardiomyopathy DST 4186.123573 4549.729909 3822.517237 0.840163551 -0.251257896 0.292102 1 7.409769086 6.121243971 667 dystonin "GO:0003779,GO:0005178,GO:0005198,GO:0005509,GO:0005515,GO:0005604,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005789,GO:0005829,GO:0005882,GO:0005925,GO:0005938,GO:0007010,GO:0007155,GO:0007229,GO:0008017,GO:0008022,GO:0008090,GO:0009611,GO:0009925,GO:0015630,GO:0016020,GO:0016021,GO:0030011,GO:0030018,GO:0030056,GO:0031122,GO:0031252,GO:0031410,GO:0031581,GO:0031673,GO:0035371,GO:0042060,GO:0045104,GO:0048870,GO:0051010,GO:1904115" actin binding|integrin binding|structural molecule activity|calcium ion binding|protein binding|basement membrane|nucleus|nuclear envelope|nucleoplasm|cytoplasm|endoplasmic reticulum membrane|cytosol|intermediate filament|focal adhesion|cell cortex|cytoskeleton organization|cell adhesion|integrin-mediated signaling pathway|microtubule binding|protein C-terminus binding|retrograde axonal transport|response to wounding|basal plasma membrane|microtubule cytoskeleton|membrane|integral component of membrane|maintenance of cell polarity|Z disc|hemidesmosome|cytoplasmic microtubule organization|cell leading edge|cytoplasmic vesicle|hemidesmosome assembly|H zone|microtubule plus-end|wound healing|intermediate filament cytoskeleton organization|cell motility|microtubule plus-end binding|axon cytoplasm DSTN 4984.380529 4209.514569 5759.246488 1.368149793 0.452226194 0.059829797 1 57.36824714 77.17495914 11034 "destrin, actin depolymerizing factor" "GO:0005515,GO:0005737,GO:0008154,GO:0015629,GO:0030042,GO:0030043,GO:0030836,GO:0030864,GO:0048870,GO:0051014,GO:0051015,GO:0070062" protein binding|cytoplasm|actin polymerization or depolymerization|actin cytoskeleton|actin filament depolymerization|actin filament fragmentation|positive regulation of actin filament depolymerization|cortical actin cytoskeleton|cell motility|actin filament severing|actin filament binding|extracellular exosome DSTYK 1102.171167 1178.788929 1025.553405 0.87000597 -0.200902795 0.410650686 1 7.792617196 6.666175661 25778 dual serine/threonine and tyrosine protein kinase "GO:0004674,GO:0004712,GO:0004713,GO:0005524,GO:0005737,GO:0016323,GO:0016324,GO:0018108,GO:0030054,GO:0033674,GO:0043066,GO:0044344,GO:0045743,GO:0070374" protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|ATP binding|cytoplasm|basolateral plasma membrane|apical plasma membrane|peptidyl-tyrosine phosphorylation|cell junction|positive regulation of kinase activity|negative regulation of apoptotic process|cellular response to fibroblast growth factor stimulus|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade DTD1 1391.17091 1347.335978 1435.005842 1.065069044 0.090946958 0.7063089 1 16.81198149 17.60628972 92675 D-aminoacyl-tRNA deacylase 1 "GO:0000049,GO:0003677,GO:0005634,GO:0005737,GO:0006260,GO:0006399,GO:0046872,GO:0051500,GO:0106074" tRNA binding|DNA binding|nucleus|cytoplasm|DNA replication|tRNA metabolic process|metal ion binding|D-tyrosyl-tRNA(Tyr) deacylase activity|aminoacyl-tRNA metabolism involved in translational fidelity DTD2 328.0693696 311.0837509 345.0549882 1.109202866 0.14952325 0.631340838 1 6.11941321 6.674088197 112487 D-aminoacyl-tRNA deacylase 2 "GO:0000049,GO:0005515,GO:0005737,GO:0006399,GO:0051500,GO:0106074,GO:0106105" tRNA binding|protein binding|cytoplasm|tRNA metabolic process|D-tyrosyl-tRNA(Tyr) deacylase activity|aminoacyl-tRNA metabolism involved in translational fidelity|Ala-tRNA(Thr) hydrolase activity DTL 2042.863717 2269.142678 1816.584757 0.800559954 -0.320918645 0.174898547 1 27.93540351 21.98973466 51514 denticleless E3 ubiquitin protein ligase homolog "GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005813,GO:0005829,GO:0006260,GO:0006511,GO:0006513,GO:0006974,GO:0009411,GO:0010971,GO:0019985,GO:0031464,GO:0031465,GO:0031965,GO:0042769,GO:0043687,GO:0045732,GO:0048511,GO:0051726,GO:0072425,GO:0080008" "protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|centrosome|cytosol|DNA replication|ubiquitin-dependent protein catabolic process|protein monoubiquitination|cellular response to DNA damage stimulus|response to UV|positive regulation of G2/M transition of mitotic cell cycle|translesion synthesis|Cul4A-RING E3 ubiquitin ligase complex|Cul4B-RING E3 ubiquitin ligase complex|nuclear membrane|DNA damage response, detection of DNA damage|post-translational protein modification|positive regulation of protein catabolic process|rhythmic process|regulation of cell cycle|signal transduction involved in G2 DNA damage checkpoint|Cul4-RING E3 ubiquitin ligase complex" DTNA 389.1971219 275.7096789 502.684565 1.823238731 0.866503477 0.003061001 0.360292185 1.379922989 2.473828373 1837 dystrobrevin alpha "GO:0005515,GO:0005654,GO:0005737,GO:0005886,GO:0006941,GO:0007165,GO:0007268,GO:0007274,GO:0008270,GO:0030054,GO:0032991,GO:0045111,GO:0045202,GO:0099536" protein binding|nucleoplasm|cytoplasm|plasma membrane|striated muscle contraction|signal transduction|chemical synaptic transmission|neuromuscular synaptic transmission|zinc ion binding|cell junction|protein-containing complex|intermediate filament cytoskeleton|synapse|synaptic signaling DTNB 246.3862046 273.6288511 219.143558 0.800878844 -0.320344085 0.343350688 1 1.817884835 1.431542898 1838 dystrobrevin beta "GO:0005515,GO:0005737,GO:0005886,GO:0008270,GO:0045202,GO:0099536" protein binding|cytoplasm|plasma membrane|zinc ion binding|synapse|synaptic signaling DTNBP1 251.5241073 244.4972624 258.5509522 1.057479947 0.080630306 0.820137055 1 3.871919741 4.025961948 84062 dystrobrevin binding protein 1 "GO:0001956,GO:0005515,GO:0005634,GO:0005737,GO:0005789,GO:0005829,GO:0005886,GO:0006469,GO:0007596,GO:0008089,GO:0010008,GO:0010628,GO:0014059,GO:0014069,GO:0015630,GO:0016528,GO:0030424,GO:0030426,GO:0030496,GO:0030672,GO:0031083,GO:0031175,GO:0031532,GO:0032091,GO:0032438,GO:0033162,GO:0042383,GO:0043005,GO:0043197,GO:0043506,GO:0045211,GO:0048490,GO:0048812,GO:0048813,GO:0060155,GO:0060159,GO:0071901,GO:0098685,GO:0098686,GO:0098978,GO:1904115,GO:2000300" positive regulation of neurotransmitter secretion|protein binding|nucleus|cytoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|negative regulation of protein kinase activity|blood coagulation|anterograde axonal transport|endosome membrane|positive regulation of gene expression|regulation of dopamine secretion|postsynaptic density|microtubule cytoskeleton|sarcoplasm|axon|growth cone|midbody|synaptic vesicle membrane|BLOC-1 complex|neuron projection development|actin cytoskeleton reorganization|negative regulation of protein binding|melanosome organization|melanosome membrane|sarcolemma|neuron projection|dendritic spine|regulation of JUN kinase activity|postsynaptic membrane|anterograde synaptic vesicle transport|neuron projection morphogenesis|dendrite morphogenesis|platelet dense granule organization|regulation of dopamine receptor signaling pathway|negative regulation of protein serine/threonine kinase activity|Schaffer collateral - CA1 synapse|hippocampal mossy fiber to CA3 synapse|glutamatergic synapse|axon cytoplasm|regulation of synaptic vesicle exocytosis DTWD1 404.084364 401.5997587 406.5689694 1.01237354 0.017741706 0.960417213 1 2.187004185 2.177015787 56986 DTW domain containing 1 "GO:0005634,GO:0006400,GO:0016432" nucleus|tRNA modification|tRNA-uridine aminocarboxypropyltransferase activity DTWD2 153.9227328 155.0216685 152.823797 0.985822166 -0.020600675 0.977210111 1 1.396324309 1.353493132 285605 DTW domain containing 2 "GO:0005634,GO:0005737,GO:0006400,GO:0016432" nucleus|cytoplasm|tRNA modification|tRNA-uridine aminocarboxypropyltransferase activity DTX2 408.1422239 369.3469283 446.9375195 1.210075095 0.275096582 0.340448033 1 4.258234335 5.066558468 113878 deltex E3 ubiquitin ligase 2 "GO:0005515,GO:0005654,GO:0005737,GO:0007219,GO:0008270,GO:0016567,GO:0031965,GO:0061630" protein binding|nucleoplasm|cytoplasm|Notch signaling pathway|zinc ion binding|protein ubiquitination|nuclear membrane|ubiquitin protein ligase activity hsa04330 Notch signaling pathway DTX3 377.8161215 393.2764476 362.3557954 0.921376801 -0.118136821 0.693864746 1 6.598063879 5.97757409 196403 deltex E3 ubiquitin ligase 3 "GO:0005515,GO:0005654,GO:0005737,GO:0007219,GO:0016567,GO:0046872,GO:0061630" protein binding|nucleoplasm|cytoplasm|Notch signaling pathway|protein ubiquitination|metal ion binding|ubiquitin protein ligase activity hsa04330 Notch signaling pathway DTX3L 1001.576884 1162.142307 841.0114615 0.723673389 -0.466589374 0.057619336 1 10.75266973 7.651209399 151636 deltex E3 ubiquitin ligase 3L "GO:0000209,GO:0002230,GO:0004842,GO:0004857,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005765,GO:0005769,GO:0005829,GO:0006302,GO:0006511,GO:0006974,GO:0007219,GO:0008047,GO:0008333,GO:0010390,GO:0015031,GO:0016032,GO:0016567,GO:0019899,GO:0031901,GO:0032092,GO:0032991,GO:0033522,GO:0033523,GO:0035563,GO:0042393,GO:0044389,GO:0045087,GO:0045893,GO:0046872,GO:0051444,GO:0051607,GO:0051865,GO:0061630,GO:0070936,GO:0097677,GO:1900182,GO:1901666,GO:1902966,GO:2000646,GO:2001034" "protein polyubiquitination|positive regulation of defense response to virus by host|ubiquitin-protein transferase activity|enzyme inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|lysosome|lysosomal membrane|early endosome|cytosol|double-strand break repair|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|Notch signaling pathway|enzyme activator activity|endosome to lysosome transport|histone monoubiquitination|protein transport|viral process|protein ubiquitination|enzyme binding|early endosome membrane|positive regulation of protein binding|protein-containing complex|histone H2A ubiquitination|histone H2B ubiquitination|positive regulation of chromatin binding|histone binding|ubiquitin-like protein ligase binding|innate immune response|positive regulation of transcription, DNA-templated|metal ion binding|negative regulation of ubiquitin-protein transferase activity|defense response to virus|protein autoubiquitination|ubiquitin protein ligase activity|protein K48-linked ubiquitination|STAT family protein binding|positive regulation of protein localization to nucleus|positive regulation of NAD+ ADP-ribosyltransferase activity|positive regulation of protein localization to early endosome|positive regulation of receptor catabolic process|positive regulation of double-strand break repair via nonhomologous end joining" hsa04330 Notch signaling pathway DTX4 366.470334 423.4484502 309.4922178 0.73088523 -0.452283216 0.126751508 1 3.668019075 2.636039718 23220 deltex E3 ubiquitin ligase 4 "GO:0004842,GO:0005654,GO:0005829,GO:0007219,GO:0008270,GO:0016567,GO:0032479,GO:0061630" ubiquitin-protein transferase activity|nucleoplasm|cytosol|Notch signaling pathway|zinc ion binding|protein ubiquitination|regulation of type I interferon production|ubiquitin protein ligase activity hsa04330 Notch signaling pathway DTYMK 1133.439532 1002.958983 1263.920082 1.260191198 0.333642638 0.170217684 1 44.53084655 55.17833249 1841 deoxythymidylate kinase "GO:0004550,GO:0004798,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005758,GO:0005759,GO:0005829,GO:0006165,GO:0006227,GO:0006233,GO:0006235,GO:0009041,GO:0015949,GO:0043627,GO:0045445,GO:0046105,GO:0046686,GO:0046940,GO:0071363" nucleoside diphosphate kinase activity|thymidylate kinase activity|ATP binding|nucleus|cytoplasm|mitochondrion|mitochondrial intermembrane space|mitochondrial matrix|cytosol|nucleoside diphosphate phosphorylation|dUDP biosynthetic process|dTDP biosynthetic process|dTTP biosynthetic process|uridylate kinase activity|nucleobase-containing small molecule interconversion|response to estrogen|myoblast differentiation|thymidine biosynthetic process|response to cadmium ion|nucleoside monophosphate phosphorylation|cellular response to growth factor stimulus hsa00240 Pyrimidine metabolism DUS1L 935.1941853 920.7662861 949.6220845 1.031338895 0.044518477 0.861293606 1 21.38363986 21.68473938 64118 dihydrouridine synthase 1 like "GO:0002943,GO:0005515,GO:0017150,GO:0050660,GO:0055114" tRNA dihydrouridine synthesis|protein binding|tRNA dihydrouridine synthase activity|flavin adenine dinucleotide binding|oxidation-reduction process DUS2 346.4351284 351.6598923 341.2103644 0.97028513 -0.043519332 0.894762461 1 9.468941539 9.033831578 54920 dihydrouridine synthase 2 "GO:0002943,GO:0003725,GO:0004860,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0006469,GO:0010181,GO:0017150,GO:0050660,GO:0055114,GO:0060548,GO:0070402,GO:0102264" tRNA dihydrouridine synthesis|double-stranded RNA binding|protein kinase inhibitor activity|protein binding|cytoplasm|endoplasmic reticulum|cytosol|negative regulation of protein kinase activity|FMN binding|tRNA dihydrouridine synthase activity|flavin adenine dinucleotide binding|oxidation-reduction process|negative regulation of cell death|NADPH binding|tRNA-dihydrouridine20 synthase activity DUS3L 171.0549633 175.8299462 166.2799804 0.945686352 -0.080566319 0.848785438 1 4.595358014 4.273046826 56931 dihydrouridine synthase 3 like "GO:0002943,GO:0003723,GO:0005515,GO:0017150,GO:0046872,GO:0050660,GO:0055114" tRNA dihydrouridine synthesis|RNA binding|protein binding|tRNA dihydrouridine synthase activity|metal ion binding|flavin adenine dinucleotide binding|oxidation-reduction process DUS4L 120.2973656 117.5667687 123.0279624 1.046451848 0.065505928 0.900592127 1 2.965180704 3.050995682 11062 dihydrouridine synthase 4 like "GO:0002943,GO:0017150,GO:0050660,GO:0055114" tRNA dihydrouridine synthesis|tRNA dihydrouridine synthase activity|flavin adenine dinucleotide binding|oxidation-reduction process DUS4L-BCAP29 192.2796522 177.9107739 206.6485305 1.16152904 0.216025225 0.565364688 1 1.390564004 1.588152615 115253422 DUS4L-BCAP29 readthrough DUSP1 3359.995321 2896.512249 3823.478393 1.320028387 0.400568955 0.091405887 1 76.79162205 99.67087951 1843 dual specificity phosphatase 1 "GO:0000188,GO:0001706,GO:0004721,GO:0004722,GO:0004725,GO:0005515,GO:0005634,GO:0005737,GO:0006470,GO:0007162,GO:0008138,GO:0008330,GO:0009416,GO:0017017,GO:0019838,GO:0032355,GO:0032526,GO:0032870,GO:0033574,GO:0035335,GO:0035556,GO:0035970,GO:0042542,GO:0043065,GO:0043066,GO:0043407,GO:0043409,GO:0051019,GO:0051384,GO:0051447,GO:0051591,GO:0051592,GO:0070262,GO:0070373,GO:0071850,GO:0090027,GO:0090266,GO:0106306,GO:0106307,GO:1903753,GO:1990869,GO:2000279" inactivation of MAPK activity|endoderm formation|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|protein dephosphorylation|negative regulation of cell adhesion|protein tyrosine/serine/threonine phosphatase activity|protein tyrosine/threonine phosphatase activity|response to light stimulus|MAP kinase tyrosine/serine/threonine phosphatase activity|growth factor binding|response to estradiol|response to retinoic acid|cellular response to hormone stimulus|response to testosterone|peptidyl-tyrosine dephosphorylation|intracellular signal transduction|peptidyl-threonine dephosphorylation|response to hydrogen peroxide|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of MAP kinase activity|negative regulation of MAPK cascade|mitogen-activated protein kinase binding|response to glucocorticoid|negative regulation of meiotic cell cycle|response to cAMP|response to calcium ion|peptidyl-serine dephosphorylation|negative regulation of ERK1 and ERK2 cascade|mitotic cell cycle arrest|negative regulation of monocyte chemotaxis|regulation of mitotic cell cycle spindle assembly checkpoint|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of p38MAPK cascade|cellular response to chemokine|negative regulation of DNA biosynthetic process "hsa04010,hsa04726,hsa05012,hsa05418" MAPK signaling pathway|Serotonergic synapse|Parkinson disease|Fluid shear stress and atherosclerosis DUSP10 470.7551409 524.3685969 417.1416849 0.795512331 -0.330043801 0.234175895 1 3.359091137 2.6274828 11221 dual specificity phosphatase 10 "GO:0000188,GO:0002819,GO:0004721,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006470,GO:0008330,GO:0008432,GO:0010633,GO:0016311,GO:0016607,GO:0016791,GO:0017017,GO:0030336,GO:0032496,GO:0033549,GO:0035335,GO:0035970,GO:0043508,GO:0044387,GO:0045591,GO:0046329,GO:0048273,GO:0048709,GO:0048715,GO:0050680,GO:0051019,GO:0060266,GO:0070373,GO:0090335,GO:0106306,GO:0106307,GO:1903753,GO:1905042,GO:1990264" inactivation of MAPK activity|regulation of adaptive immune response|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|protein dephosphorylation|protein tyrosine/threonine phosphatase activity|JUN kinase binding|negative regulation of epithelial cell migration|dephosphorylation|nuclear speck|phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|negative regulation of cell migration|response to lipopolysaccharide|MAP kinase phosphatase activity|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|negative regulation of JUN kinase activity|negative regulation of protein kinase activity by regulation of protein phosphorylation|positive regulation of regulatory T cell differentiation|negative regulation of JNK cascade|mitogen-activated protein kinase p38 binding|oligodendrocyte differentiation|negative regulation of oligodendrocyte differentiation|negative regulation of epithelial cell proliferation|mitogen-activated protein kinase binding|negative regulation of respiratory burst involved in inflammatory response|negative regulation of ERK1 and ERK2 cascade|regulation of brown fat cell differentiation|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of p38MAPK cascade|negative regulation of epithelium regeneration|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity hsa04010 MAPK signaling pathway DUSP11 621.9340287 531.651494 712.2165634 1.339630512 0.421835141 0.106374327 1 17.31132587 22.80271404 8446 dual specificity phosphatase 11 "GO:0001650,GO:0003723,GO:0004651,GO:0004725,GO:0005634,GO:0005654,GO:0006396,GO:0006470,GO:0008138,GO:0016070,GO:0016607,GO:0016791,GO:0035335,GO:0045171,GO:0098507,GO:0098519" "fibrillar center|RNA binding|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|nucleus|nucleoplasm|RNA processing|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|RNA metabolic process|nuclear speck|phosphatase activity|peptidyl-tyrosine dephosphorylation|intercellular bridge|polynucleotide 5' dephosphorylation|nucleotide phosphatase activity, acting on free nucleotides" DUSP12 652.8633976 700.198543 605.5282523 0.864795076 -0.209569786 0.419998558 1 29.49353538 25.07905808 11266 dual specificity phosphatase 12 "GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006464,GO:0006470,GO:0008138,GO:0008270,GO:0016311,GO:0016791,GO:0019900,GO:0033133,GO:0035335,GO:0106306,GO:0106307" protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cellular protein modification process|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|zinc ion binding|dephosphorylation|phosphatase activity|kinase binding|positive regulation of glucokinase activity|peptidyl-tyrosine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity DUSP14 508.3295419 501.4794914 515.1795924 1.027319364 0.038884744 0.893724579 1 8.689298304 8.777308437 11072 dual specificity phosphatase 14 "GO:0000188,GO:0003723,GO:0004725,GO:0005515,GO:0017017,GO:0035335,GO:0106306,GO:0106307" inactivation of MAPK activity|RNA binding|protein tyrosine phosphatase activity|protein binding|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity DUSP15 18.25693275 12.48496659 24.0288989 1.924626608 0.944578579 0.295986232 1 0.172975005 0.327341461 128853 dual specificity phosphatase 15 "GO:0004725,GO:0005515,GO:0005829,GO:0005886,GO:0007179,GO:0008138,GO:0016311,GO:0016791,GO:0035335,GO:0042127,GO:0046330,GO:0106306,GO:0106307" protein tyrosine phosphatase activity|protein binding|cytosol|plasma membrane|transforming growth factor beta receptor signaling pathway|protein tyrosine/serine/threonine phosphatase activity|dephosphorylation|phosphatase activity|peptidyl-tyrosine dephosphorylation|regulation of cell population proliferation|positive regulation of JNK cascade|protein serine phosphatase activity|protein threonine phosphatase activity DUSP16 755.1271274 748.0575816 762.1966731 1.018901074 0.027013985 0.920586429 1 6.128716343 6.14006148 80824 dual specificity phosphatase 16 "GO:0000188,GO:0004721,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006470,GO:0008330,GO:0016311,GO:0016791,GO:0017017,GO:0031410,GO:0035335,GO:0035970,GO:0045204,GO:0045209,GO:0051019,GO:0106306,GO:0106307" "inactivation of MAPK activity|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein dephosphorylation|protein tyrosine/threonine phosphatase activity|dephosphorylation|phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|cytoplasmic vesicle|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive|mitogen-activated protein kinase binding|protein serine phosphatase activity|protein threonine phosphatase activity" hsa04010 MAPK signaling pathway DUSP18 352.6826421 351.6598923 353.7053918 1.005816698 0.00836741 0.988522177 1 3.549733711 3.510635943 150290 dual specificity phosphatase 18 "GO:0000188,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005743,GO:0008138,GO:0016311,GO:0016791,GO:0017017,GO:0035335,GO:0035970,GO:0106306,GO:0106307" inactivation of MAPK activity|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrial inner membrane|protein tyrosine/serine/threonine phosphatase activity|dephosphorylation|phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity DUSP19 29.98391862 30.1720026 29.79583464 0.987532549 -0.018099795 1 1 0.310195401 0.30120207 142679 dual specificity phosphatase 19 "GO:0004725,GO:0004860,GO:0005078,GO:0005515,GO:0005737,GO:0006469,GO:0008579,GO:0030295,GO:0031435,GO:0032147,GO:0035335,GO:0043405,GO:0043410,GO:0043507,GO:0043508,GO:0045860,GO:0046329,GO:0046330,GO:0106306,GO:0106307" protein tyrosine phosphatase activity|protein kinase inhibitor activity|MAP-kinase scaffold activity|protein binding|cytoplasm|negative regulation of protein kinase activity|JUN kinase phosphatase activity|protein kinase activator activity|mitogen-activated protein kinase kinase kinase binding|activation of protein kinase activity|peptidyl-tyrosine dephosphorylation|regulation of MAP kinase activity|positive regulation of MAPK cascade|positive regulation of JUN kinase activity|negative regulation of JUN kinase activity|positive regulation of protein kinase activity|negative regulation of JNK cascade|positive regulation of JNK cascade|protein serine phosphatase activity|protein threonine phosphatase activity DUSP22 342.3778828 282.9925761 401.7631896 1.419695157 0.505581181 0.09446235 1 2.183431208 3.047935644 56940 dual specificity phosphatase 22 "GO:0000122,GO:0004725,GO:0004726,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007179,GO:0008138,GO:0030336,GO:0031941,GO:0035335,GO:0042127,GO:0046330,GO:0051895,GO:0061851,GO:0071364,GO:0106306,GO:0106307,GO:1903996,GO:1990782" negative regulation of transcription by RNA polymerase II|protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|nucleus|cytoplasm|cytosol|plasma membrane|transforming growth factor beta receptor signaling pathway|protein tyrosine/serine/threonine phosphatase activity|negative regulation of cell migration|filamentous actin|peptidyl-tyrosine dephosphorylation|regulation of cell population proliferation|positive regulation of JNK cascade|negative regulation of focal adhesion assembly|leading edge of lamellipodium|cellular response to epidermal growth factor stimulus|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of non-membrane spanning protein tyrosine kinase activity|protein tyrosine kinase binding DUSP23 245.1577067 241.3760208 248.9393926 1.031334396 0.044512183 0.907465029 1 18.61531011 18.87734688 54935 dual specificity phosphatase 23 "GO:0004725,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0008138,GO:0016311,GO:0016791,GO:0035335,GO:0106306,GO:0106307" protein tyrosine phosphatase activity|protein binding|nucleoplasm|cytoplasm|cytosol|protein tyrosine/serine/threonine phosphatase activity|dephosphorylation|phosphatase activity|peptidyl-tyrosine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity DUSP28 64.53081281 66.58648849 62.47513714 0.938255471 -0.091947297 0.894646323 1 0.717753688 0.66216728 285193 dual specificity phosphatase 28 "GO:0004725,GO:0008138,GO:0016311,GO:0016791,GO:0035335,GO:0106306,GO:0106307" protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|dephosphorylation|phosphatase activity|peptidyl-tyrosine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity DUSP3 1827.16089 1880.027886 1774.293895 0.94375935 -0.083509063 0.726153877 1 24.50149766 22.73657675 1845 dual specificity phosphatase 3 "GO:0000188,GO:0001772,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0008092,GO:0008138,GO:0016311,GO:0016791,GO:0019901,GO:0030336,GO:0030971,GO:0033549,GO:0035335,GO:0042059,GO:0043409,GO:0045931,GO:0046329,GO:0050860,GO:0050868,GO:0050922,GO:0051893,GO:0070373,GO:0071364,GO:0106306,GO:0106307,GO:0120183,GO:1990264,GO:1990782" inactivation of MAPK activity|immunological synapse|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytosol|cytoskeletal protein binding|protein tyrosine/serine/threonine phosphatase activity|dephosphorylation|phosphatase activity|protein kinase binding|negative regulation of cell migration|receptor tyrosine kinase binding|MAP kinase phosphatase activity|peptidyl-tyrosine dephosphorylation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAPK cascade|positive regulation of mitotic cell cycle|negative regulation of JNK cascade|negative regulation of T cell receptor signaling pathway|negative regulation of T cell activation|negative regulation of chemotaxis|regulation of focal adhesion assembly|negative regulation of ERK1 and ERK2 cascade|cellular response to epidermal growth factor stimulus|protein serine phosphatase activity|protein threonine phosphatase activity|positive regulation of focal adhesion disassembly|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity|protein tyrosine kinase binding hsa04010 MAPK signaling pathway DUSP4 98.2505292 68.66731625 127.8337421 1.861638828 0.896573206 0.057500678 1 0.503870269 0.922327887 1846 dual specificity phosphatase 4 "GO:0000188,GO:0001706,GO:0004721,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006470,GO:0008330,GO:0016311,GO:0016791,GO:0017017,GO:0035335,GO:0035970,GO:0051019,GO:0070373,GO:0106306,GO:0106307,GO:1990439" inactivation of MAPK activity|endoderm formation|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|protein dephosphorylation|protein tyrosine/threonine phosphatase activity|dephosphorylation|phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|mitogen-activated protein kinase binding|negative regulation of ERK1 and ERK2 cascade|protein serine phosphatase activity|protein threonine phosphatase activity|MAP kinase serine/threonine phosphatase activity hsa04010 MAPK signaling pathway DUSP5 1919.942008 1906.038233 1933.845783 1.014589188 0.020895692 0.931979002 1 41.06651488 40.9684239 1847 dual specificity phosphatase 5 "GO:0000165,GO:0000187,GO:0000188,GO:0001706,GO:0004721,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006470,GO:0008138,GO:0008330,GO:0016311,GO:0016791,GO:0017017,GO:0035335,GO:0035970,GO:0051019,GO:0106306,GO:0106307" MAPK cascade|activation of MAPK activity|inactivation of MAPK activity|endoderm formation|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|protein tyrosine/threonine phosphatase activity|dephosphorylation|phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|mitogen-activated protein kinase binding|protein serine phosphatase activity|protein threonine phosphatase activity hsa04010 MAPK signaling pathway DUSP6 2060.861411 1732.289115 2389.433707 1.379350414 0.463989009 0.049984931 1 25.48913323 34.57011748 1848 dual specificity phosphatase 6 "GO:0000165,GO:0000187,GO:0000188,GO:0004721,GO:0004725,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006470,GO:0008330,GO:0014070,GO:0017017,GO:0030154,GO:0035335,GO:0035970,GO:0042493,GO:0043065,GO:0051019,GO:0051409,GO:0060420,GO:0070373,GO:0070848,GO:0106306,GO:0106307" MAPK cascade|activation of MAPK activity|inactivation of MAPK activity|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleoplasm|cytoplasm|cytosol|protein dephosphorylation|protein tyrosine/threonine phosphatase activity|response to organic cyclic compound|MAP kinase tyrosine/serine/threonine phosphatase activity|cell differentiation|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|response to drug|positive regulation of apoptotic process|mitogen-activated protein kinase binding|response to nitrosative stress|regulation of heart growth|negative regulation of ERK1 and ERK2 cascade|response to growth factor|protein serine phosphatase activity|protein threonine phosphatase activity "hsa04010,hsa05202,hsa05221" MAPK signaling pathway|Transcriptional misregulation in cancer|Acute myeloid leukemia DUSP7 740.1059071 656.5011599 823.7106543 1.254697942 0.327340089 0.198007068 1 10.42435594 12.8605516 1849 dual specificity phosphatase 7 "GO:0000165,GO:0000187,GO:0000188,GO:0004721,GO:0004725,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006470,GO:0008330,GO:0017017,GO:0035335,GO:0035970,GO:0043407,GO:0051019,GO:0106306,GO:0106307" MAPK cascade|activation of MAPK activity|inactivation of MAPK activity|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleoplasm|cytoplasm|cytosol|protein dephosphorylation|protein tyrosine/threonine phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|negative regulation of MAP kinase activity|mitogen-activated protein kinase binding|protein serine phosphatase activity|protein threonine phosphatase activity hsa04010 MAPK signaling pathway DUSP8 70.05494435 72.82897178 67.28091692 0.923820772 -0.11431511 0.854611368 1 0.653454669 0.593573313 1850 dual specificity phosphatase 8 "GO:0000188,GO:0004721,GO:0004725,GO:0005634,GO:0005737,GO:0005829,GO:0006470,GO:0008330,GO:0016311,GO:0016791,GO:0017017,GO:0035335,GO:0035970,GO:0051019,GO:0106306,GO:0106307" inactivation of MAPK activity|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|nucleus|cytoplasm|cytosol|protein dephosphorylation|protein tyrosine/threonine phosphatase activity|dephosphorylation|phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|mitogen-activated protein kinase binding|protein serine phosphatase activity|protein threonine phosphatase activity hsa04010 MAPK signaling pathway DUSP9 3.923881751 2.080827765 5.766935736 2.771462315 1.470647391 0.503574097 1 0.038266697 0.104280026 1852 dual specificity phosphatase 9 "GO:0000165,GO:0000187,GO:0000188,GO:0004721,GO:0004725,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006470,GO:0007254,GO:0008330,GO:0017017,GO:0035335,GO:0035970,GO:0043065,GO:0051019,GO:0060420,GO:0070373,GO:0106306,GO:0106307" MAPK cascade|activation of MAPK activity|inactivation of MAPK activity|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|cytosol|protein dephosphorylation|JNK cascade|protein tyrosine/threonine phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|positive regulation of apoptotic process|mitogen-activated protein kinase binding|regulation of heart growth|negative regulation of ERK1 and ERK2 cascade|protein serine phosphatase activity|protein threonine phosphatase activity "hsa04010,hsa04550" MAPK signaling pathway|Signaling pathways regulating pluripotency of stem cells DUT 1184.995354 968.6253247 1401.365384 1.446756912 0.532822537 0.028061439 0.877967194 16.16440066 22.99462605 1854 deoxyuridine triphosphatase "GO:0000287,GO:0001889,GO:0003723,GO:0004170,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006139,GO:0006226,GO:0006260,GO:0014070,GO:0015949,GO:0030547,GO:0032556,GO:0042802,GO:0042975,GO:0043254,GO:0046081,GO:0070062,GO:2000272" magnesium ion binding|liver development|RNA binding|dUTP diphosphatase activity|protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|nucleobase-containing compound metabolic process|dUMP biosynthetic process|DNA replication|response to organic cyclic compound|nucleobase-containing small molecule interconversion|receptor inhibitor activity|pyrimidine deoxyribonucleotide binding|identical protein binding|peroxisome proliferator activated receptor binding|regulation of protein-containing complex assembly|dUTP catabolic process|extracellular exosome|negative regulation of signaling receptor activity "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes DVL1 3149.497136 2908.997216 3389.997057 1.165349021 0.220762105 0.35152868 1 50.63530166 58.0203836 1855 dishevelled segment polarity protein 1 "GO:0001505,GO:0001934,GO:0003674,GO:0005109,GO:0005515,GO:0005829,GO:0005874,GO:0006355,GO:0006469,GO:0007269,GO:0007411,GO:0007507,GO:0007528,GO:0008013,GO:0010976,GO:0014069,GO:0016328,GO:0019899,GO:0019901,GO:0021915,GO:0022007,GO:0030136,GO:0030426,GO:0031122,GO:0031410,GO:0032091,GO:0032436,GO:0034504,GO:0035176,GO:0035372,GO:0035556,GO:0035567,GO:0042802,GO:0043005,GO:0043025,GO:0043113,GO:0043197,GO:0045202,GO:0045944,GO:0048668,GO:0048675,GO:0048813,GO:0050808,GO:0050821,GO:0060070,GO:0060071,GO:0060134,GO:0060997,GO:0071340,GO:0090090,GO:0090103,GO:0090179,GO:0098685,GO:0098793,GO:0098978,GO:0099054,GO:0150012,GO:1903827,GO:1904886,GO:1905386,GO:1990909,GO:2000300,GO:2000463" "regulation of neurotransmitter levels|positive regulation of protein phosphorylation|molecular_function|frizzled binding|protein binding|cytosol|microtubule|regulation of transcription, DNA-templated|negative regulation of protein kinase activity|neurotransmitter secretion|axon guidance|heart development|neuromuscular junction development|beta-catenin binding|positive regulation of neuron projection development|postsynaptic density|lateral plasma membrane|enzyme binding|protein kinase binding|neural tube development|convergent extension involved in neural plate elongation|clathrin-coated vesicle|growth cone|cytoplasmic microtubule organization|cytoplasmic vesicle|negative regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein localization to nucleus|social behavior|protein localization to microtubule|intracellular signal transduction|non-canonical Wnt signaling pathway|identical protein binding|neuron projection|neuronal cell body|receptor clustering|dendritic spine|synapse|positive regulation of transcription by RNA polymerase II|collateral sprouting|axon extension|dendrite morphogenesis|synapse organization|protein stabilization|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|prepulse inhibition|dendritic spine morphogenesis|skeletal muscle acetylcholine-gated channel clustering|negative regulation of canonical Wnt signaling pathway|cochlea morphogenesis|planar cell polarity pathway involved in neural tube closure|Schaffer collateral - CA1 synapse|presynapse|glutamatergic synapse|presynapse assembly|positive regulation of neuron projection arborization|regulation of cellular protein localization|beta-catenin destruction complex disassembly|positive regulation of protein localization to presynapse|Wnt signalosome|regulation of synaptic vesicle exocytosis|positive regulation of excitatory postsynaptic potential" "hsa04150,hsa04310,hsa04330,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Notch signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer DVL2 1500.265298 1637.611451 1362.919146 0.83226039 -0.264893118 0.267097738 1 29.23931527 23.92751529 1856 dishevelled segment polarity protein 2 "GO:0001843,GO:0001934,GO:0003151,GO:0005109,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0007379,GO:0007507,GO:0016235,GO:0016328,GO:0016604,GO:0019901,GO:0019904,GO:0022007,GO:0030674,GO:0031267,GO:0031410,GO:0034613,GO:0035329,GO:0035567,GO:0042802,GO:0043507,GO:0043547,GO:0043621,GO:0044340,GO:0045177,GO:0045334,GO:0045944,GO:0051091,GO:0060070,GO:0060071,GO:0061024,GO:0061098,GO:0090090,GO:0090103,GO:0090179,GO:0150012,GO:1904886" "neural tube closure|positive regulation of protein phosphorylation|outflow tract morphogenesis|frizzled binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|segment specification|heart development|aggresome|lateral plasma membrane|nuclear body|protein kinase binding|protein domain specific binding|convergent extension involved in neural plate elongation|protein-macromolecule adaptor activity|small GTPase binding|cytoplasmic vesicle|cellular protein localization|hippo signaling|non-canonical Wnt signaling pathway|identical protein binding|positive regulation of JUN kinase activity|positive regulation of GTPase activity|protein self-association|canonical Wnt signaling pathway involved in regulation of cell proliferation|apical part of cell|clathrin-coated endocytic vesicle|positive regulation of transcription by RNA polymerase II|positive regulation of DNA-binding transcription factor activity|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|membrane organization|positive regulation of protein tyrosine kinase activity|negative regulation of canonical Wnt signaling pathway|cochlea morphogenesis|planar cell polarity pathway involved in neural tube closure|positive regulation of neuron projection arborization|beta-catenin destruction complex disassembly" "hsa04150,hsa04310,hsa04330,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Notch signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer DVL3 1624.818054 1829.047606 1420.588503 0.776682082 -0.364603911 0.125253315 1 17.65152063 13.48020788 1857 dishevelled segment polarity protein 3 "GO:0000785,GO:0001934,GO:0002020,GO:0005102,GO:0005109,GO:0005515,GO:0005829,GO:0008013,GO:0031267,GO:0035556,GO:0035567,GO:0038031,GO:0042493,GO:0043507,GO:0043547,GO:0045893,GO:0045944,GO:0050821,GO:0060070,GO:0060071,GO:0090090,GO:0090179,GO:0150012,GO:1903827,GO:1904886" "chromatin|positive regulation of protein phosphorylation|protease binding|signaling receptor binding|frizzled binding|protein binding|cytosol|beta-catenin binding|small GTPase binding|intracellular signal transduction|non-canonical Wnt signaling pathway|non-canonical Wnt signaling pathway via JNK cascade|response to drug|positive regulation of JUN kinase activity|positive regulation of GTPase activity|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein stabilization|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|negative regulation of canonical Wnt signaling pathway|planar cell polarity pathway involved in neural tube closure|positive regulation of neuron projection arborization|regulation of cellular protein localization|beta-catenin destruction complex disassembly" "hsa04150,hsa04310,hsa04330,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Notch signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer DXO 243.8398901 232.0122958 255.6674843 1.101956616 0.140067426 0.686958777 1 8.092856084 8.768746045 1797 decapping exoribonuclease "GO:0000166,GO:0000287,GO:0000956,GO:0003729,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006402,GO:0008409,GO:0034353,GO:0050779,GO:0071028,GO:0090305,GO:0110152,GO:0110155" nucleotide binding|magnesium ion binding|nuclear-transcribed mRNA catabolic process|mRNA binding|nucleus|nucleoplasm|cytosol|plasma membrane|mRNA catabolic process|5'-3' exonuclease activity|RNA pyrophosphohydrolase activity|RNA destabilization|nuclear mRNA surveillance|nucleic acid phosphodiester bond hydrolysis|RNA NAD-cap (NAD-forming) hydrolase activity|NAD-cap decapping DYDC2 13.61469924 4.161655531 23.06774294 5.54292463 2.470647391 0.021987001 0.822216713 0.111889122 0.60981488 84332 DPY30 domain containing 2 "GO:0000781,GO:0005515,GO:0006348,GO:0044666,GO:0048188,GO:0051568" "chromosome, telomeric region|protein binding|chromatin silencing at telomere|MLL3/4 complex|Set1C/COMPASS complex|histone H3-K4 methylation" DYM 1865.280036 1896.674508 1833.885564 0.966895245 -0.0485685 0.839557166 1 6.906996421 6.566588991 54808 dymeclin "GO:0005515,GO:0005737,GO:0005794,GO:0007030,GO:0016020,GO:0019899,GO:0060348" protein binding|cytoplasm|Golgi apparatus|Golgi organization|membrane|enzyme binding|bone development DYNAP 9.448013289 8.323311061 10.57271552 1.270253561 0.345116509 0.853432744 1 0.287136273 0.358632512 284254 dynactin associated protein "GO:0000139,GO:0005515,GO:0005794,GO:0005886,GO:0008284,GO:0016021,GO:0032148,GO:0042981,GO:1901625" Golgi membrane|protein binding|Golgi apparatus|plasma membrane|positive regulation of cell population proliferation|integral component of membrane|activation of protein kinase B activity|regulation of apoptotic process|cellular response to ergosterol DYNC1H1 18346.0867 19922.88544 16769.28796 0.841709802 -0.248605176 0.356850394 1 53.32235603 44.1309111 1778 dynein cytoplasmic 1 heavy chain 1 "GO:0000086,GO:0000278,GO:0003723,GO:0005515,GO:0005524,GO:0005576,GO:0005813,GO:0005829,GO:0005868,GO:0005874,GO:0005881,GO:0005938,GO:0006888,GO:0007018,GO:0007052,GO:0007097,GO:0008090,GO:0008569,GO:0010389,GO:0016020,GO:0019886,GO:0030286,GO:0031122,GO:0032388,GO:0033962,GO:0034063,GO:0035578,GO:0043312,GO:0045505,GO:0051293,GO:0051301,GO:0051959,GO:0060236,GO:0070062,GO:0072382,GO:0090235,GO:0097711,GO:0120162,GO:1904115,GO:1905832" "G2/M transition of mitotic cell cycle|mitotic cell cycle|RNA binding|protein binding|ATP binding|extracellular region|centrosome|cytosol|cytoplasmic dynein complex|microtubule|cytoplasmic microtubule|cell cortex|endoplasmic reticulum to Golgi vesicle-mediated transport|microtubule-based movement|mitotic spindle organization|nuclear migration|retrograde axonal transport|ATP-dependent microtubule motor activity, minus-end-directed|regulation of G2/M transition of mitotic cell cycle|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|dynein complex|cytoplasmic microtubule organization|positive regulation of intracellular transport|P-body assembly|stress granule assembly|azurophil granule lumen|neutrophil degranulation|dynein intermediate chain binding|establishment of spindle localization|cell division|dynein light intermediate chain binding|regulation of mitotic spindle organization|extracellular exosome|minus-end-directed vesicle transport along microtubule|regulation of metaphase plate congression|ciliary basal body-plasma membrane docking|positive regulation of cold-induced thermogenesis|axon cytoplasm|positive regulation of spindle assembly" "hsa04145,hsa04962,hsa05132" Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection DYNC1I1 59.97286765 47.8590386 72.0866967 1.506229519 0.590941625 0.296721657 1 0.764257609 1.131884478 1780 dynein cytoplasmic 1 intermediate chain 1 "GO:0000776,GO:0000777,GO:0000922,GO:0003774,GO:0003777,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005868,GO:0005874,GO:0006888,GO:0007018,GO:0008017,GO:0010970,GO:0019886,GO:0030507,GO:0031982,GO:0036464,GO:0045503,GO:0045504,GO:0047496,GO:0048471,GO:0055037" kinetochore|condensed chromosome kinetochore|spindle pole|motor activity|microtubule motor activity|protein binding|nucleus|cytoplasm|cytosol|cytoplasmic dynein complex|microtubule|endoplasmic reticulum to Golgi vesicle-mediated transport|microtubule-based movement|microtubule binding|transport along microtubule|antigen processing and presentation of exogenous peptide antigen via MHC class II|spectrin binding|vesicle|cytoplasmic ribonucleoprotein granule|dynein light chain binding|dynein heavy chain binding|vesicle transport along microtubule|perinuclear region of cytoplasm|recycling endosome "hsa04145,hsa04962,hsa05132" Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection DYNC1I2 3372.250732 3193.030206 3551.471257 1.112257332 0.153490609 0.517877845 1 37.64218103 41.16719105 1781 dynein cytoplasmic 1 intermediate chain 2 "GO:0000086,GO:0003777,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005868,GO:0005874,GO:0006888,GO:0007018,GO:0010389,GO:0010970,GO:0016032,GO:0019886,GO:0031982,GO:0045503,GO:0045504,GO:0097711" G2/M transition of mitotic cell cycle|microtubule motor activity|protein binding|cytoplasm|centrosome|cytosol|cytoplasmic dynein complex|microtubule|endoplasmic reticulum to Golgi vesicle-mediated transport|microtubule-based movement|regulation of G2/M transition of mitotic cell cycle|transport along microtubule|viral process|antigen processing and presentation of exogenous peptide antigen via MHC class II|vesicle|dynein light chain binding|dynein heavy chain binding|ciliary basal body-plasma membrane docking "hsa04145,hsa04962,hsa05132" Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection DYNC1LI1 892.9139985 794.8762063 990.9517906 1.246674366 0.318084679 0.200775571 1 17.07085803 20.925679 51143 dynein cytoplasmic 1 light intermediate chain 1 "GO:0000226,GO:0000776,GO:0000777,GO:0000922,GO:0003723,GO:0003774,GO:0005515,GO:0005524,GO:0005525,GO:0005813,GO:0005829,GO:0005868,GO:0005874,GO:0005886,GO:0006888,GO:0007018,GO:0007049,GO:0016020,GO:0016032,GO:0019003,GO:0019886,GO:0030667,GO:0043312,GO:0045504,GO:0051301,GO:0090267,GO:0101003" microtubule cytoskeleton organization|kinetochore|condensed chromosome kinetochore|spindle pole|RNA binding|motor activity|protein binding|ATP binding|GTP binding|centrosome|cytosol|cytoplasmic dynein complex|microtubule|plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|microtubule-based movement|cell cycle|membrane|viral process|GDP binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|secretory granule membrane|neutrophil degranulation|dynein heavy chain binding|cell division|positive regulation of mitotic cell cycle spindle assembly checkpoint|ficolin-1-rich granule membrane "hsa04145,hsa04962,hsa05132" Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection DYNC1LI2 3202.160726 3206.555586 3197.765866 0.997258828 -0.003960106 0.988153218 1 38.76936526 38.01611727 1783 dynein cytoplasmic 1 light intermediate chain 2 "GO:0000226,GO:0000776,GO:0003774,GO:0005524,GO:0005764,GO:0005770,GO:0005813,GO:0005829,GO:0005868,GO:0005874,GO:0006888,GO:0007018,GO:0016020,GO:0019886,GO:0042802,GO:0045504,GO:0051642,GO:1990090" microtubule cytoskeleton organization|kinetochore|motor activity|ATP binding|lysosome|late endosome|centrosome|cytosol|cytoplasmic dynein complex|microtubule|endoplasmic reticulum to Golgi vesicle-mediated transport|microtubule-based movement|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|identical protein binding|dynein heavy chain binding|centrosome localization|cellular response to nerve growth factor stimulus "hsa04145,hsa04962,hsa05132" Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection DYNC2H1 1369.454968 1471.14523 1267.764706 0.861753605 -0.214652665 0.371233486 1 5.822628083 4.933706819 79659 dynein cytoplasmic 2 heavy chain 1 "GO:0001822,GO:0003774,GO:0005515,GO:0005524,GO:0005794,GO:0005868,GO:0005874,GO:0005886,GO:0005929,GO:0005930,GO:0007018,GO:0007030,GO:0007368,GO:0008569,GO:0009953,GO:0016485,GO:0021522,GO:0030286,GO:0030326,GO:0030900,GO:0031514,GO:0035721,GO:0035735,GO:0045177,GO:0045505,GO:0045880,GO:0051959,GO:0060271,GO:0060976,GO:0061512,GO:0070062,GO:0097542,GO:1905515" "kidney development|motor activity|protein binding|ATP binding|Golgi apparatus|cytoplasmic dynein complex|microtubule|plasma membrane|cilium|axoneme|microtubule-based movement|Golgi organization|determination of left/right symmetry|ATP-dependent microtubule motor activity, minus-end-directed|dorsal/ventral pattern formation|protein processing|spinal cord motor neuron differentiation|dynein complex|embryonic limb morphogenesis|forebrain development|motile cilium|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|apical part of cell|dynein intermediate chain binding|positive regulation of smoothened signaling pathway|dynein light intermediate chain binding|cilium assembly|coronary vasculature development|protein localization to cilium|extracellular exosome|ciliary tip|non-motile cilium assembly" "hsa04145,hsa04962,hsa05132" Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection DYNC2I1 428.2818396 380.791481 475.7721982 1.249429732 0.321269767 0.258705906 1 4.127999488 5.071339086 55112 dynein 2 intermediate chain 1 "GO:0000242,GO:0000922,GO:0005515,GO:0005615,GO:0005813,GO:0005868,GO:0005929,GO:0007018,GO:0031021,GO:0035721,GO:0035735,GO:0042073,GO:0045503,GO:0045504,GO:0048704,GO:0060271,GO:0097014,GO:0097542,GO:0097546" pericentriolar material|spindle pole|protein binding|extracellular space|centrosome|cytoplasmic dynein complex|cilium|microtubule-based movement|interphase microtubule organizing center|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|intraciliary transport|dynein light chain binding|dynein heavy chain binding|embryonic skeletal system morphogenesis|cilium assembly|ciliary plasm|ciliary tip|ciliary base DYNC2I2 1787.9579 1670.904696 1905.011105 1.140107578 0.18916996 0.42554869 1 53.20591444 59.64539548 89891 dynein 2 intermediate chain 2 "GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0005868,GO:0005929,GO:0005930,GO:0007018,GO:0030175,GO:0035721,GO:0035735,GO:0036064,GO:0042073,GO:0045503,GO:0045504,GO:0060271,GO:0097014,GO:0097542" protein binding|cytoplasm|centrosome|centriole|cytosol|cytoplasmic dynein complex|cilium|axoneme|microtubule-based movement|filopodium|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|dynein light chain binding|dynein heavy chain binding|cilium assembly|ciliary plasm|ciliary tip DYNC2LI1 219.5883086 188.3149128 250.8617045 1.332139345 0.413745 0.239529759 1 3.301583701 4.324572137 51626 dynein cytoplasmic 2 light intermediate chain 1 "GO:0003774,GO:0005515,GO:0005737,GO:0005794,GO:0005813,GO:0005868,GO:0005881,GO:0005929,GO:0005930,GO:0007368,GO:0030990,GO:0031514,GO:0035721,GO:0035735,GO:0035869,GO:0036064,GO:0045177,GO:0045504,GO:0097542,GO:1902017" motor activity|protein binding|cytoplasm|Golgi apparatus|centrosome|cytoplasmic dynein complex|cytoplasmic microtubule|cilium|axoneme|determination of left/right symmetry|intraciliary transport particle|motile cilium|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|ciliary transition zone|ciliary basal body|apical part of cell|dynein heavy chain binding|ciliary tip|regulation of cilium assembly "hsa04962,hsa05132" Vasopressin-regulated water reabsorption|Salmonella infection DYNLL1 3151.398712 3059.857229 3242.940196 1.059833827 0.083838079 0.724271008 1 173.7222942 181.0358191 8655 dynein light chain LC8-type 1 "GO:0000086,GO:0000776,GO:0003774,GO:0004857,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005813,GO:0005829,GO:0005868,GO:0005874,GO:0005886,GO:0005929,GO:0006888,GO:0006915,GO:0007286,GO:0008022,GO:0008180,GO:0010389,GO:0016020,GO:0016032,GO:0016236,GO:0019886,GO:0019899,GO:0019904,GO:0021762,GO:0030235,GO:0030286,GO:0035721,GO:0035735,GO:0035774,GO:0042326,GO:0042802,GO:0043086,GO:0043312,GO:0044458,GO:0044877,GO:0045019,GO:0045505,GO:0051959,GO:0060271,GO:0070821,GO:0072686,GO:0097110,GO:0097542,GO:0097711,GO:0101003,GO:1902857,GO:1904115,GO:2000582" "G2/M transition of mitotic cell cycle|kinetochore|motor activity|enzyme inhibitor activity|protein binding|nucleus|cytoplasm|mitochondrion|centrosome|cytosol|cytoplasmic dynein complex|microtubule|plasma membrane|cilium|endoplasmic reticulum to Golgi vesicle-mediated transport|apoptotic process|spermatid development|protein C-terminus binding|COP9 signalosome|regulation of G2/M transition of mitotic cell cycle|membrane|viral process|macroautophagy|antigen processing and presentation of exogenous peptide antigen via MHC class II|enzyme binding|protein domain specific binding|substantia nigra development|nitric-oxide synthase regulator activity|dynein complex|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|positive regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of phosphorylation|identical protein binding|negative regulation of catalytic activity|neutrophil degranulation|motile cilium assembly|protein-containing complex binding|negative regulation of nitric oxide biosynthetic process|dynein intermediate chain binding|dynein light intermediate chain binding|cilium assembly|tertiary granule membrane|mitotic spindle|scaffold protein binding|ciliary tip|ciliary basal body-plasma membrane docking|ficolin-1-rich granule membrane|positive regulation of non-motile cilium assembly|axon cytoplasm|positive regulation of ATP-dependent microtubule motor activity, plus-end-directed" "hsa04962,hsa05132" Vasopressin-regulated water reabsorption|Salmonella infection DYNLL2 982.9840268 989.4336024 976.5344513 0.986963096 -0.018931954 0.94312629 1 7.7573458 7.528097652 140735 dynein light chain LC8-type 2 "GO:0003774,GO:0005515,GO:0005634,GO:0005813,GO:0005829,GO:0005868,GO:0005874,GO:0005886,GO:0005929,GO:0006888,GO:0014069,GO:0016020,GO:0016236,GO:0019886,GO:0030286,GO:0031475,GO:0035735,GO:0042802,GO:0044877,GO:0045505,GO:0051959,GO:0060271,GO:0097110,GO:0097542,GO:0097731,GO:0098794,GO:0098978,GO:2000582" "motor activity|protein binding|nucleus|centrosome|cytosol|cytoplasmic dynein complex|microtubule|plasma membrane|cilium|endoplasmic reticulum to Golgi vesicle-mediated transport|postsynaptic density|membrane|macroautophagy|antigen processing and presentation of exogenous peptide antigen via MHC class II|dynein complex|myosin V complex|intraciliary transport involved in cilium assembly|identical protein binding|protein-containing complex binding|dynein intermediate chain binding|dynein light intermediate chain binding|cilium assembly|scaffold protein binding|ciliary tip|9+0 non-motile cilium|postsynapse|glutamatergic synapse|positive regulation of ATP-dependent microtubule motor activity, plus-end-directed" "hsa04962,hsa05132" Vasopressin-regulated water reabsorption|Salmonella infection DYNLRB1 3501.148811 3334.526494 3667.771128 1.099937618 0.137421705 0.563020987 1 112.5601204 121.7373329 83658 dynein light chain roadblock-type 1 "GO:0003777,GO:0005515,GO:0005737,GO:0005813,GO:0005868,GO:0005874,GO:0005929,GO:0007018,GO:0007632,GO:0016020,GO:0035735,GO:0045505,GO:0097542" microtubule motor activity|protein binding|cytoplasm|centrosome|cytoplasmic dynein complex|microtubule|cilium|microtubule-based movement|visual behavior|membrane|intraciliary transport involved in cilium assembly|dynein intermediate chain binding|ciliary tip hsa05132 Salmonella infection DYNLRB2 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.207182749 0.094098456 83657 dynein light chain roadblock-type 2 "GO:0003777,GO:0005737,GO:0005813,GO:0005868,GO:0005874,GO:0005929,GO:0007018,GO:0035735,GO:0045505,GO:0097542" microtubule motor activity|cytoplasm|centrosome|cytoplasmic dynein complex|microtubule|cilium|microtubule-based movement|intraciliary transport involved in cilium assembly|dynein intermediate chain binding|ciliary tip hsa05132 Salmonella infection DYNLT1 1336.549796 1137.172374 1535.927218 1.350654706 0.433658897 0.0711184 1 83.13534185 110.4081674 6993 dynein light chain Tctex-type 1 "GO:0000132,GO:0003774,GO:0005515,GO:0005576,GO:0005739,GO:0005794,GO:0005819,GO:0005868,GO:0005881,GO:0008022,GO:0008277,GO:0010976,GO:0016358,GO:0019060,GO:0030027,GO:0034774,GO:0035022,GO:0035795,GO:0042802,GO:0043025,GO:0043087,GO:0043312,GO:0043657,GO:0044295,GO:0046718,GO:0048812,GO:0050768,GO:0051301,GO:0051493,GO:0060548,GO:0061564,GO:0075521,GO:0099503,GO:1904813" establishment of mitotic spindle orientation|motor activity|protein binding|extracellular region|mitochondrion|Golgi apparatus|spindle|cytoplasmic dynein complex|cytoplasmic microtubule|protein C-terminus binding|regulation of G protein-coupled receptor signaling pathway|positive regulation of neuron projection development|dendrite development|intracellular transport of viral protein in host cell|lamellipodium|secretory granule lumen|positive regulation of Rac protein signal transduction|negative regulation of mitochondrial membrane permeability|identical protein binding|neuronal cell body|regulation of GTPase activity|neutrophil degranulation|host cell|axonal growth cone|viral entry into host cell|neuron projection morphogenesis|negative regulation of neurogenesis|cell division|regulation of cytoskeleton organization|negative regulation of cell death|axon development|microtubule-dependent intracellular transport of viral material towards nucleus|secretory vesicle|ficolin-1-rich granule lumen hsa05132 Salmonella infection DYNLT2 9.888962303 7.282897178 12.49502743 1.715667148 0.778769686 0.540720238 1 0.447266786 0.754520185 6991 dynein light chain Tctex-type 2 "GO:0003774,GO:0005515,GO:0005737,GO:0005874,GO:0016020,GO:0030286" motor activity|protein binding|cytoplasm|microtubule|membrane|dynein complex DYNLT2B 46.68023054 39.53572754 53.82473354 1.361420085 0.445112299 0.48215701 1 3.375918584 4.519134804 255758 dynein light chain Tctex-type 2B "GO:0000922,GO:0005515,GO:0005813,GO:0005868,GO:0005930,GO:0031021,GO:0035721,GO:0045505,GO:0060271,GO:0097546,GO:1902017,GO:1905799" spindle pole|protein binding|centrosome|cytoplasmic dynein complex|axoneme|interphase microtubule organizing center|intraciliary retrograde transport|dynein intermediate chain binding|cilium assembly|ciliary base|regulation of cilium assembly|regulation of intraciliary retrograde transport DYNLT3 796.6751 703.3197847 890.0304153 1.265470465 0.339673837 0.177403436 1 17.44996944 21.71290154 6990 dynein light chain Tctex-type 3 "GO:0000776,GO:0000777,GO:0003774,GO:0005515,GO:0005634,GO:0005737,GO:0005868,GO:0005874,GO:0007049,GO:0007346,GO:0042802,GO:0051301" kinetochore|condensed chromosome kinetochore|motor activity|protein binding|nucleus|cytoplasm|cytoplasmic dynein complex|microtubule|cell cycle|regulation of mitotic cell cycle|identical protein binding|cell division hsa05132 Salmonella infection DYRK1A 887.0527136 830.2502783 943.8551488 1.136832078 0.185019168 0.458362891 1 3.826002195 4.276738663 1859 dual specificity tyrosine phosphorylation regulated kinase 1A "GO:0000381,GO:0003713,GO:0004672,GO:0004674,GO:0004712,GO:0004713,GO:0004715,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005856,GO:0006468,GO:0007399,GO:0007623,GO:0016032,GO:0016607,GO:0018105,GO:0018107,GO:0018108,GO:0030424,GO:0030425,GO:0031115,GO:0033120,GO:0034205,GO:0036289,GO:0038083,GO:0042802,GO:0043518,GO:0043621,GO:0045893,GO:0046777,GO:0048025,GO:0048156,GO:0050321,GO:0090312,GO:1990904" "regulation of alternative mRNA splicing, via spliceosome|transcription coactivator activity|protein kinase activity|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytoskeleton|protein phosphorylation|nervous system development|circadian rhythm|viral process|nuclear speck|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|axon|dendrite|negative regulation of microtubule polymerization|positive regulation of RNA splicing|amyloid-beta formation|peptidyl-serine autophosphorylation|peptidyl-tyrosine autophosphorylation|identical protein binding|negative regulation of DNA damage response, signal transduction by p53 class mediator|protein self-association|positive regulation of transcription, DNA-templated|protein autophosphorylation|negative regulation of mRNA splicing, via spliceosome|tau protein binding|tau-protein kinase activity|positive regulation of protein deacetylation|ribonucleoprotein complex" DYRK1B 126.5845082 118.6071826 134.5618338 1.134516737 0.182077893 0.685327117 1 2.003750347 2.235247905 9149 dual specificity tyrosine phosphorylation regulated kinase 1B "GO:0003713,GO:0004672,GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0006468,GO:0007520,GO:0018105,GO:0018107,GO:0018108,GO:0045893,GO:0046777,GO:0060612" "transcription coactivator activity|protein kinase activity|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|chromosome|protein phosphorylation|myoblast fusion|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|positive regulation of transcription, DNA-templated|protein autophosphorylation|adipose tissue development" DYRK2 1092.332509 1046.656366 1138.008652 1.087280113 0.120723666 0.622792698 1 5.800428513 6.201156643 8445 dual specificity tyrosine phosphorylation regulated kinase 2 "GO:0000151,GO:0000287,GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006468,GO:0006974,GO:0007224,GO:0018105,GO:0018107,GO:0018108,GO:0030145,GO:0042771,GO:0045725,GO:0070885,GO:1901796,GO:1990904" ubiquitin ligase complex|magnesium ion binding|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|protein phosphorylation|cellular response to DNA damage stimulus|smoothened signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|manganese ion binding|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of glycogen biosynthetic process|negative regulation of calcineurin-NFAT signaling cascade|regulation of signal transduction by p53 class mediator|ribonucleoprotein complex DYRK3 934.3167033 1011.282294 857.3511127 0.84778614 -0.238227714 0.336125166 1 6.493836767 5.413259649 8444 dual specificity tyrosine phosphorylation regulated kinase 3 "GO:0000242,GO:0000287,GO:0004672,GO:0004674,GO:0004712,GO:0004713,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006468,GO:0007049,GO:0010494,GO:0016607,GO:0018105,GO:0018107,GO:0018108,GO:0030218,GO:0035063,GO:0035617,GO:0043066,GO:0043231,GO:0043518,GO:0051301,GO:0080135,GO:1902751,GO:1903008,GO:1903432" "pericentriolar material|magnesium ion binding|protein kinase activity|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|protein phosphorylation|cell cycle|cytoplasmic stress granule|nuclear speck|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|erythrocyte differentiation|nuclear speck organization|stress granule disassembly|negative regulation of apoptotic process|intracellular membrane-bounded organelle|negative regulation of DNA damage response, signal transduction by p53 class mediator|cell division|regulation of cellular response to stress|positive regulation of cell cycle G2/M phase transition|organelle disassembly|regulation of TORC1 signaling" DYRK4 281.7954895 256.982229 306.60875 1.193112657 0.254730272 0.432492032 1 3.869827666 4.539878776 8798 dual specificity tyrosine phosphorylation regulated kinase 4 "GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005856,GO:0018105,GO:0018107,GO:0018108,GO:0043231,GO:0046872" protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytoskeleton|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|intracellular membrane-bounded organelle|metal ion binding DYSF 429.916688 398.4785171 461.3548589 1.157791046 0.211374904 0.459038163 1 2.739766308 3.118996487 8291 dysferlin "GO:0001778,GO:0002280,GO:0002281,GO:0005509,GO:0005515,GO:0005543,GO:0005544,GO:0005768,GO:0005769,GO:0005770,GO:0005886,GO:0006906,GO:0006936,GO:0007009,GO:0016021,GO:0030139,GO:0030315,GO:0030659,GO:0031410,GO:0033292,GO:0034451,GO:0042383,GO:0050765,GO:0061025,GO:0070062" plasma membrane repair|monocyte activation involved in immune response|macrophage activation involved in immune response|calcium ion binding|protein binding|phospholipid binding|calcium-dependent phospholipid binding|endosome|early endosome|late endosome|plasma membrane|vesicle fusion|muscle contraction|plasma membrane organization|integral component of membrane|endocytic vesicle|T-tubule|cytoplasmic vesicle membrane|cytoplasmic vesicle|T-tubule organization|centriolar satellite|sarcolemma|negative regulation of phagocytosis|membrane fusion|extracellular exosome DZANK1 132.7477336 129.0113214 136.4841458 1.057923787 0.081235699 0.865217999 1 1.050838998 1.093104651 55184 double zinc ribbon and ankyrin repeat domains 1 GO:0046872 metal ion binding DZIP1 991.6495217 951.9787026 1031.320341 1.083343921 0.115491318 0.64117638 1 6.451473485 6.87221038 22873 DAZ interacting zinc finger protein 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005814,GO:0005829,GO:0007224,GO:0007275,GO:0007281,GO:0007283,GO:0034451,GO:0036064,GO:0043393,GO:0045184,GO:0045724,GO:0046872,GO:0051220,GO:0060271,GO:0061512,GO:0097539" protein binding|nucleus|nucleoplasm|cytoplasm|centriole|cytosol|smoothened signaling pathway|multicellular organism development|germ cell development|spermatogenesis|centriolar satellite|ciliary basal body|regulation of protein binding|establishment of protein localization|positive regulation of cilium assembly|metal ion binding|cytoplasmic sequestering of protein|cilium assembly|protein localization to cilium|ciliary transition fiber DZIP1L 277.0538764 296.5179566 257.5897962 0.868715673 -0.203044029 0.53555715 1 1.418103626 1.211314185 199221 DAZ interacting zinc finger protein 1 like "GO:0005515,GO:0005737,GO:0005814,GO:0005930,GO:0007224,GO:0021532,GO:0032880,GO:0033504,GO:0036064,GO:0046872,GO:0060271,GO:0061512,GO:1905349" protein binding|cytoplasm|centriole|axoneme|smoothened signaling pathway|neural tube patterning|regulation of protein localization|floor plate development|ciliary basal body|metal ion binding|cilium assembly|protein localization to cilium|ciliary transition zone assembly DZIP3 421.0033585 454.6608667 387.3458503 0.851944556 -0.231168551 0.419891418 1 4.327521817 3.625114903 9666 DAZ interacting zinc finger protein 3 "GO:0000209,GO:0003723,GO:0004842,GO:0005515,GO:0005737,GO:0019902,GO:0031593,GO:0046872,GO:0061630" protein polyubiquitination|RNA binding|ubiquitin-protein transferase activity|protein binding|cytoplasm|phosphatase binding|polyubiquitin modification-dependent protein binding|metal ion binding|ubiquitin protein ligase activity E2F1 1161.496723 944.6958054 1378.297641 1.458985668 0.544965711 0.024914123 0.86041596 18.7422598 26.88711211 1869 E2F transcription factor 1 "GO:0000077,GO:0000082,GO:0000083,GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0000987,GO:0001216,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005813,GO:0006351,GO:0006355,GO:0006357,GO:0006977,GO:0007283,GO:0008134,GO:0008630,GO:0010628,GO:0016032,GO:0019901,GO:0030900,GO:0032991,GO:0035189,GO:0043065,GO:0043276,GO:0043392,GO:0043565,GO:0045599,GO:0045892,GO:0045893,GO:0045944,GO:0046983,GO:0048146,GO:0048255,GO:0060252,GO:0070317,GO:0070345,GO:0071398,GO:0071456,GO:0071466,GO:0071930,GO:0072332,GO:0090575,GO:1900740,GO:1990086,GO:1990090,GO:1990837,GO:2000045" "DNA damage checkpoint|G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|mitochondrion|centrosome|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|spermatogenesis|transcription factor binding|intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of gene expression|viral process|protein kinase binding|forebrain development|protein-containing complex|Rb-E2F complex|positive regulation of apoptotic process|anoikis|negative regulation of DNA binding|sequence-specific DNA binding|negative regulation of fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|positive regulation of fibroblast proliferation|mRNA stabilization|positive regulation of glial cell proliferation|negative regulation of G0 to G1 transition|negative regulation of fat cell proliferation|cellular response to fatty acid|cellular response to hypoxia|cellular response to xenobiotic stimulus|negative regulation of transcription involved in G1/S transition of mitotic cell cycle|intrinsic apoptotic signaling pathway by p53 class mediator|RNA polymerase II transcription regulator complex|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|lens fiber cell apoptotic process|cellular response to nerve growth factor stimulus|sequence-specific double-stranded DNA binding|regulation of G1/S transition of mitotic cell cycle" "hsa01522,hsa04110,hsa04137,hsa04218,hsa04934,hsa05160,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05169,hsa05200,hsa05206,hsa05212,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" Endocrine resistance|Cell cycle|Mitophagy - animal|Cellular senescence|Cushing syndrome|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|MicroRNAs in cancer|Pancreatic cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer E2F E2F2 76.09928283 80.11186896 72.0866967 0.899825427 -0.15228296 0.788814544 1 0.716151291 0.633627793 1870 E2F transcription factor 2 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0000987,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005654,GO:0006357,GO:0006367,GO:0007049,GO:0008134,GO:0043565,GO:0045944,GO:0046983,GO:0051726,GO:0072332,GO:0090575,GO:1903671,GO:1990086,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|cell cycle|transcription factor binding|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|protein dimerization activity|regulation of cell cycle|intrinsic apoptotic signaling pathway by p53 class mediator|RNA polymerase II transcription regulator complex|negative regulation of sprouting angiogenesis|lens fiber cell apoptotic process|sequence-specific double-stranded DNA binding" "hsa01522,hsa04110,hsa04218,hsa04934,hsa05160,hsa05161,hsa05163,hsa05166,hsa05167,hsa05169,hsa05200,hsa05206,hsa05212,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" Endocrine resistance|Cell cycle|Cellular senescence|Cushing syndrome|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|MicroRNAs in cancer|Pancreatic cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer E2F E2F3 576.417515 585.7530159 567.082014 0.968124787 -0.046735078 0.866312848 1 3.456879563 3.290688454 1871 E2F transcription factor 3 "GO:0000082,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0000987,GO:0001216,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006367,GO:0006606,GO:0008284,GO:0043565,GO:0045944,GO:0046983,GO:0070345,GO:0090575,GO:1905461,GO:1990837" "G1/S transition of mitotic cell cycle|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|protein import into nucleus|positive regulation of cell population proliferation|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|protein dimerization activity|negative regulation of fat cell proliferation|RNA polymerase II transcription regulator complex|positive regulation of vascular associated smooth muscle cell apoptotic process|sequence-specific double-stranded DNA binding" "hsa01522,hsa04110,hsa04218,hsa04934,hsa05160,hsa05161,hsa05163,hsa05166,hsa05167,hsa05169,hsa05200,hsa05206,hsa05212,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" Endocrine resistance|Cell cycle|Cellular senescence|Cushing syndrome|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|MicroRNAs in cancer|Pancreatic cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer E2F E2F4 1507.078293 1526.287166 1487.86942 0.974829281 -0.036778509 0.880164875 1 38.60433215 37.00290219 1874 E2F transcription factor 4 "GO:0000083,GO:0000785,GO:0000978,GO:0000981,GO:0001216,GO:0001228,GO:0002064,GO:0003677,GO:0003700,GO:0005515,GO:0005654,GO:0005737,GO:0006357,GO:0006884,GO:0006977,GO:0008015,GO:0008134,GO:0009887,GO:0019904,GO:0042127,GO:0044458,GO:0045944,GO:0046983,GO:0090575,GO:0098534,GO:1903251,GO:1990837,GO:1990841" "regulation of transcription involved in G1/S transition of mitotic cell cycle|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity|DNA-binding transcription activator activity, RNA polymerase II-specific|epithelial cell development|DNA binding|DNA-binding transcription factor activity|protein binding|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|cell volume homeostasis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|blood circulation|transcription factor binding|animal organ morphogenesis|protein domain specific binding|regulation of cell population proliferation|motile cilium assembly|positive regulation of transcription by RNA polymerase II|protein dimerization activity|RNA polymerase II transcription regulator complex|centriole assembly|multi-ciliated epithelial cell differentiation|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding" "hsa04110,hsa04218,hsa04350" Cell cycle|Cellular senescence|TGF-beta signaling pathway E2F E2F5 430.5406905 440.0950724 420.9863087 0.956580374 -0.064041903 0.828744242 1 11.20566085 10.53974537 1875 E2F transcription factor 5 "GO:0000785,GO:0000978,GO:0000981,GO:0001216,GO:0001650,GO:0003700,GO:0005515,GO:0005654,GO:0005730,GO:0006357,GO:0008134,GO:0030030,GO:0043231,GO:0045944,GO:0046983,GO:0051726,GO:0090575" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity|fibrillar center|DNA-binding transcription factor activity|protein binding|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|transcription factor binding|cell projection organization|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|protein dimerization activity|regulation of cell cycle|RNA polymerase II transcription regulator complex" "hsa04110,hsa04218,hsa04350" Cell cycle|Cellular senescence|TGF-beta signaling pathway E2F6 303.500142 359.9832034 247.0170807 0.686190573 -0.543318788 0.082787754 1 3.726797661 2.514500581 1876 E2F transcription factor 6 "GO:0000083,GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0046983,GO:0070317,GO:0071339,GO:0090575" "regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|protein dimerization activity|negative regulation of G0 to G1 transition|MLL1 complex|RNA polymerase II transcription regulator complex" E2F E2F7 4961.48528 5172.937824 4750.032735 0.918246632 -0.123046396 0.60840571 1 49.05298227 44.28900658 144455 E2F transcription factor 7 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0000987,GO:0001217,GO:0001227,GO:0001890,GO:0002040,GO:0003700,GO:0005515,GO:0005654,GO:0006357,GO:0006977,GO:0008285,GO:0016607,GO:0030330,GO:0032466,GO:0032877,GO:0042802,GO:0045944,GO:0060707,GO:0060718,GO:0070365,GO:0071930,GO:0090575,GO:1990837,GO:2000134" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity|DNA-binding transcription repressor activity, RNA polymerase II-specific|placenta development|sprouting angiogenesis|DNA-binding transcription factor activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell population proliferation|nuclear speck|DNA damage response, signal transduction by p53 class mediator|negative regulation of cytokinesis|positive regulation of DNA endoreduplication|identical protein binding|positive regulation of transcription by RNA polymerase II|trophoblast giant cell differentiation|chorionic trophoblast cell differentiation|hepatocyte differentiation|negative regulation of transcription involved in G1/S transition of mitotic cell cycle|RNA polymerase II transcription regulator complex|sequence-specific double-stranded DNA binding|negative regulation of G1/S transition of mitotic cell cycle" E2F E2F8 220.930663 236.1739514 205.6873746 0.870914736 -0.199396611 0.575522036 1 3.186894997 2.729069352 79733 E2F transcription factor 8 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0000987,GO:0001217,GO:0001227,GO:0001890,GO:0002040,GO:0003700,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0006977,GO:0008283,GO:0032466,GO:0032877,GO:0033301,GO:0042802,GO:0045944,GO:0060707,GO:0060718,GO:0070365,GO:0090575,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity|DNA-binding transcription repressor activity, RNA polymerase II-specific|placenta development|sprouting angiogenesis|DNA-binding transcription factor activity|protein binding|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|cell population proliferation|negative regulation of cytokinesis|positive regulation of DNA endoreduplication|cell cycle comprising mitosis without cytokinesis|identical protein binding|positive regulation of transcription by RNA polymerase II|trophoblast giant cell differentiation|chorionic trophoblast cell differentiation|hepatocyte differentiation|RNA polymerase II transcription regulator complex|sequence-specific double-stranded DNA binding" E2F E4F1 355.0754711 376.6298255 333.5211167 0.885540906 -0.175369144 0.562164205 1 7.808873959 6.799362863 1877 E4F transcription factor 1 "GO:0000122,GO:0000977,GO:0000978,GO:0001227,GO:0001228,GO:0003700,GO:0005515,GO:0005654,GO:0005737,GO:0005819,GO:0006260,GO:0006357,GO:0009794,GO:0010564,GO:0016032,GO:0016567,GO:0016740,GO:0035497,GO:0040008,GO:0045944,GO:0046872,GO:0051301,GO:0071850" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|cytoplasm|spindle|DNA replication|regulation of transcription by RNA polymerase II|regulation of mitotic cell cycle, embryonic|regulation of cell cycle process|viral process|protein ubiquitination|transferase activity|cAMP response element binding|regulation of growth|positive regulation of transcription by RNA polymerase II|metal ion binding|cell division|mitotic cell cycle arrest" EAF1 929.7889407 917.6450445 941.9328369 1.026467524 0.037687984 0.883259984 1 9.959940912 10.05247853 85403 ELL associated factor 1 "GO:0003711,GO:0005515,GO:0005654,GO:0006366,GO:0006368,GO:0008023,GO:0015030,GO:0016604,GO:0016607,GO:0032783,GO:0034243,GO:0043231,GO:0045171" transcription elongation regulator activity|protein binding|nucleoplasm|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|transcription elongation factor complex|Cajal body|nuclear body|nuclear speck|super elongation complex|regulation of transcription elongation from RNA polymerase II promoter|intracellular membrane-bounded organelle|intercellular bridge EAF2 37.50961999 38.49531366 36.52392633 0.948788901 -0.075840962 0.952619866 1 0.491724303 0.458735603 55840 ELL associated factor 2 "GO:0003711,GO:0005515,GO:0005654,GO:0006366,GO:0006368,GO:0006915,GO:0008023,GO:0016607,GO:0032783,GO:0034243,GO:0045944" transcription elongation regulator activity|protein binding|nucleoplasm|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|apoptotic process|transcription elongation factor complex|nuclear speck|super elongation complex|regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription by RNA polymerase II EAPP 691.5574705 681.4710931 701.6438479 1.029601776 0.042086447 0.875271753 1 18.71788973 18.94948215 55837 E2F associated phosphoprotein "GO:0005515,GO:0005634,GO:0005737,GO:0008284,GO:0032968,GO:0034244" protein binding|nucleus|cytoplasm|positive regulation of cell population proliferation|positive regulation of transcription elongation from RNA polymerase II promoter|negative regulation of transcription elongation from RNA polymerase II promoter EARS2 745.7332199 804.2399313 687.2265085 0.854504336 -0.226840282 0.372609974 1 7.451528993 6.260814625 124454 "glutamyl-tRNA synthetase 2, mitochondrial" "GO:0000049,GO:0004818,GO:0005524,GO:0005739,GO:0005759,GO:0006424,GO:0008270,GO:0050561,GO:0070127" tRNA binding|glutamate-tRNA ligase activity|ATP binding|mitochondrion|mitochondrial matrix|glutamyl-tRNA aminoacylation|zinc ion binding|glutamate-tRNA(Gln) ligase activity|tRNA aminoacylation for mitochondrial protein translation "hsa00860,hsa00970" Porphyrin and chlorophyll metabolism|Aminoacyl-tRNA biosynthesis EBAG9 289.5193357 270.5076095 308.5310619 1.140563337 0.189746564 0.55784647 1 4.986699118 5.592471132 9166 estrogen receptor binding site associated antigen 9 "GO:0000139,GO:0001558,GO:0005515,GO:0006915,GO:0016021,GO:0016505,GO:0030141" Golgi membrane|regulation of cell growth|protein binding|apoptotic process|integral component of membrane|peptidase activator activity involved in apoptotic process|secretory granule hsa04915 Estrogen signaling pathway EBF4 86.47888395 62.42483296 110.5329349 1.770656479 0.824284345 0.094832032 1 1.090506908 1.898601906 57593 EBF family member 4 "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0007275,GO:0046872,GO:0046983" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|metal ion binding|protein dimerization activity" EBI3 88.38107419 112.3646993 64.39744905 0.573111034 -0.803113422 0.100102195 1 4.323502152 2.43638338 10148 Epstein-Barr virus induced 3 "GO:0004896,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005886,GO:0006959,GO:0009897,GO:0017046,GO:0019221,GO:0019955,GO:0032729,GO:0033210,GO:0042088,GO:0043235,GO:0046641,GO:0070106,GO:0070757" cytokine receptor activity|cytokine activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|plasma membrane|humoral immune response|external side of plasma membrane|peptide hormone binding|cytokine-mediated signaling pathway|cytokine binding|positive regulation of interferon-gamma production|leptin-mediated signaling pathway|T-helper 1 type immune response|receptor complex|positive regulation of alpha-beta T cell proliferation|interleukin-27-mediated signaling pathway|interleukin-35-mediated signaling pathway hsa04060 Cytokine-cytokine receptor interaction EBLN2 36.1024846 52.02069413 20.18427508 0.388004724 -1.365853877 0.04491819 1 1.653513303 0.630835152 55096 endogenous Bornavirus like nucleoprotein 2 EBNA1BP2 1735.550363 1632.409382 1838.691344 1.126366562 0.171676411 0.470136512 1 53.05644852 58.76098997 10969 EBNA1 binding protein 2 "GO:0003723,GO:0005515,GO:0005694,GO:0005730,GO:0006364,GO:0030687,GO:0034399,GO:0042273" "RNA binding|protein binding|chromosome|nucleolus|rRNA processing|preribosome, large subunit precursor|nuclear periphery|ribosomal large subunit biogenesis" EBP 999.1255333 984.231533 1014.019534 1.030265237 0.0430158 0.864990359 1 46.69033598 47.2984843 10682 EBP cholestenol delta-isomerase "GO:0000247,GO:0001501,GO:0004769,GO:0004888,GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0005887,GO:0006695,GO:0008203,GO:0016126,GO:0031410,GO:0033489,GO:0033490,GO:0042802,GO:0042908,GO:0042910,GO:0047750" C-8 sterol isomerase activity|skeletal system development|steroid delta-isomerase activity|transmembrane signaling receptor activity|protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of plasma membrane|cholesterol biosynthetic process|cholesterol metabolic process|sterol biosynthetic process|cytoplasmic vesicle|cholesterol biosynthetic process via desmosterol|cholesterol biosynthetic process via lathosterol|identical protein binding|xenobiotic transport|xenobiotic transmembrane transporter activity|cholestenol delta-isomerase activity hsa00100 Steroid biosynthesis EBPL 625.0747776 588.8742576 661.2752977 1.122948217 0.167291402 0.524183021 1 30.21840079 33.36586479 84650 EBP like "GO:0005783,GO:0005789,GO:0016021,GO:0016125,GO:0047750" endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|sterol metabolic process|cholestenol delta-isomerase activity ECD 2024.653902 1841.532572 2207.775231 1.198879273 0.261686386 0.268815319 1 30.78922581 36.29488287 11319 ecdysoneless cell cycle regulator "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006397,GO:0008380,GO:0035035,GO:0045944" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|mRNA processing|RNA splicing|histone acetyltransferase binding|positive regulation of transcription by RNA polymerase II ECE1 5471.90644 6347.565098 4596.247782 0.724096202 -0.465746711 0.053603689 1 49.21660365 35.04120956 1889 endothelin converting enzyme 1 "GO:0001921,GO:0003100,GO:0004175,GO:0004222,GO:0005515,GO:0005765,GO:0005768,GO:0005886,GO:0007507,GO:0008270,GO:0009897,GO:0010814,GO:0010815,GO:0010816,GO:0016020,GO:0016021,GO:0016485,GO:0016486,GO:0017046,GO:0019229,GO:0031302,GO:0031982,GO:0033093,GO:0034959,GO:0042447,GO:0042733,GO:0042803,GO:0043583,GO:0048471,GO:0070062" positive regulation of receptor recycling|regulation of systemic arterial blood pressure by endothelin|endopeptidase activity|metalloendopeptidase activity|protein binding|lysosomal membrane|endosome|plasma membrane|heart development|zinc ion binding|external side of plasma membrane|substance P catabolic process|bradykinin catabolic process|calcitonin catabolic process|membrane|integral component of membrane|protein processing|peptide hormone processing|peptide hormone binding|regulation of vasoconstriction|intrinsic component of endosome membrane|vesicle|Weibel-Palade body|endothelin maturation|hormone catabolic process|embryonic digit morphogenesis|protein homodimerization activity|ear development|perinuclear region of cytoplasm|extracellular exosome ECH1 748.0222533 788.633723 707.4107836 0.897008032 -0.156807192 0.538937944 1 29.87078236 26.34596484 1891 enoyl-CoA hydratase 1 "GO:0005515,GO:0005739,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0006635,GO:0016020,GO:0051750,GO:0070062" "protein binding|mitochondrion|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid beta-oxidation|membrane|delta3,5-delta2,4-dienoyl-CoA isomerase activity|extracellular exosome" hsa04146 Peroxisome ECHDC1 690.0710772 692.9156458 687.2265085 0.991789567 -0.011894045 0.969314422 1 10.88917388 10.61904954 55862 ethylmalonyl-CoA decarboxylase 1 "GO:0004300,GO:0005515,GO:0005829,GO:0006635,GO:0016831" enoyl-CoA hydratase activity|protein binding|cytosol|fatty acid beta-oxidation|carboxy-lyase activity hsa00640 Propanoate metabolism ECHDC2 964.5132436 1110.121613 818.9048745 0.737671319 -0.438949951 0.075052035 1 8.964313838 6.502062347 55268 enoyl-CoA hydratase domain containing 2 "GO:0004300,GO:0005739,GO:0006635" enoyl-CoA hydratase activity|mitochondrion|fatty acid beta-oxidation ECHS1 846.6992547 792.7953786 900.6031308 1.135984335 0.18394294 0.46335789 1 33.13236669 37.00803109 1892 "enoyl-CoA hydratase, short chain 1" "GO:0004300,GO:0005515,GO:0005739,GO:0005759,GO:0006635" enoyl-CoA hydratase activity|protein binding|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation "hsa00062,hsa00071,hsa00280,hsa00310,hsa00380,hsa00410,hsa00640,hsa00650" "Fatty acid elongation|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|beta-Alanine metabolism|Propanoate metabolism|Butanoate metabolism" ECI1 526.0065171 561.8234966 490.1895376 0.872497396 -0.19677727 0.468747762 1 19.89614295 17.06884798 1632 enoyl-CoA delta isomerase 1 "GO:0004165,GO:0004300,GO:0005739,GO:0005759,GO:0006635,GO:0016863" "dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|intramolecular oxidoreductase activity, transposing C=C bonds" hsa00071 Fatty acid degradation ECI2 3201.113938 2623.923812 3778.304063 1.439944272 0.526012978 0.026663248 0.87229644 95.26121856 134.8754777 10455 enoyl-CoA delta isomerase 2 "GO:0000062,GO:0004165,GO:0005515,GO:0005739,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0006635,GO:0016020,GO:0033540,GO:0043231" fatty-acyl-CoA binding|dodecenoyl-CoA delta-isomerase activity|protein binding|mitochondrion|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid beta-oxidation|membrane|fatty acid beta-oxidation using acyl-CoA oxidase|intracellular membrane-bounded organelle "hsa00071,hsa04146" Fatty acid degradation|Peroxisome ECM1 366.5206382 298.5987843 434.4424921 1.454937243 0.540956926 0.06798253 1 7.492086656 10.71811053 1893 extracellular matrix protein 1 "GO:0001503,GO:0001525,GO:0001938,GO:0001960,GO:0002020,GO:0002063,GO:0002576,GO:0002828,GO:0003416,GO:0005134,GO:0005201,GO:0005515,GO:0005576,GO:0005615,GO:0006357,GO:0006954,GO:0007165,GO:0008022,GO:0010466,GO:0019899,GO:0030500,GO:0030502,GO:0031012,GO:0031089,GO:0031214,GO:0043123,GO:0043236,GO:0045766,GO:0062023,GO:0070062,GO:2000404" ossification|angiogenesis|positive regulation of endothelial cell proliferation|negative regulation of cytokine-mediated signaling pathway|protease binding|chondrocyte development|platelet degranulation|regulation of type 2 immune response|endochondral bone growth|interleukin-2 receptor binding|extracellular matrix structural constituent|protein binding|extracellular region|extracellular space|regulation of transcription by RNA polymerase II|inflammatory response|signal transduction|protein C-terminus binding|negative regulation of peptidase activity|enzyme binding|regulation of bone mineralization|negative regulation of bone mineralization|extracellular matrix|platelet dense granule lumen|biomineral tissue development|positive regulation of I-kappaB kinase/NF-kappaB signaling|laminin binding|positive regulation of angiogenesis|collagen-containing extracellular matrix|extracellular exosome|regulation of T cell migration ECM2 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.034309975 0 1842 extracellular matrix protein 2 "GO:0005178,GO:0007160,GO:0008201,GO:0010811,GO:0030198,GO:0031012,GO:0070052" integrin binding|cell-matrix adhesion|heparin binding|positive regulation of cell-substrate adhesion|extracellular matrix organization|extracellular matrix|collagen V binding ECPAS 3674.42434 4161.655531 3187.19315 0.76584742 -0.384871103 0.105435055 1 26.31827312 19.81850185 23392 Ecm29 proteasome adaptor and scaffold "GO:0000502,GO:0005515,GO:0005634,GO:0005654,GO:0005769,GO:0005770,GO:0005771,GO:0005783,GO:0005793,GO:0005802,GO:0005813,GO:0016020,GO:0030134,GO:0030139,GO:0030433,GO:0031410,GO:0043248,GO:0060090,GO:0070628" proteasome complex|protein binding|nucleus|nucleoplasm|early endosome|late endosome|multivesicular body|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|trans-Golgi network|centrosome|membrane|COPII-coated ER to Golgi transport vesicle|endocytic vesicle|ubiquitin-dependent ERAD pathway|cytoplasmic vesicle|proteasome assembly|molecular adaptor activity|proteasome binding ECSCR 11.60809898 14.56579436 8.650403604 0.593884782 -0.751745031 0.514922909 1 0.753976405 0.440282203 641700 endothelial cell surface expressed chemotaxis and apoptosis regulator "GO:0001525,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006915,GO:0006935,GO:0016021,GO:0016525,GO:0030154,GO:0043231,GO:1901800,GO:2000353" angiogenesis|protein binding|nucleoplasm|cytosol|plasma membrane|apoptotic process|chemotaxis|integral component of membrane|negative regulation of angiogenesis|cell differentiation|intracellular membrane-bounded organelle|positive regulation of proteasomal protein catabolic process|positive regulation of endothelial cell apoptotic process ECSIT 295.0780658 290.2754733 299.8806583 1.033089895 0.046965797 0.892759352 1 9.405870373 9.554506968 51295 ECSIT signaling integrator "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005743,GO:0005829,GO:0032981,GO:0045087,GO:0051341,GO:0061635" protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial inner membrane|cytosol|mitochondrial respiratory chain complex I assembly|innate immune response|regulation of oxidoreductase activity|regulation of protein complex stability hsa04010 MAPK signaling pathway ECT2 3190.165169 3358.456013 3021.874326 0.899780826 -0.152354471 0.520576917 1 32.90520008 29.11202723 1894 epithelial cell transforming 2 "GO:0000281,GO:0000902,GO:0005085,GO:0005096,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005911,GO:0005923,GO:0005938,GO:0007186,GO:0007399,GO:0015031,GO:0016604,GO:0030154,GO:0030496,GO:0031267,GO:0032147,GO:0032154,GO:0032467,GO:0035556,GO:0042307,GO:0042803,GO:0043065,GO:0043123,GO:0043547,GO:0045666,GO:0045859,GO:0051056,GO:0051260,GO:0051988,GO:0070301,GO:0070830,GO:0071277,GO:0071479,GO:0072686,GO:0090630,GO:0097149,GO:2000431" "mitotic cytokinesis|cell morphogenesis|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cell-cell junction|bicellular tight junction|cell cortex|G protein-coupled receptor signaling pathway|nervous system development|protein transport|nuclear body|cell differentiation|midbody|small GTPase binding|activation of protein kinase activity|cleavage furrow|positive regulation of cytokinesis|intracellular signal transduction|positive regulation of protein import into nucleus|protein homodimerization activity|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of GTPase activity|positive regulation of neuron differentiation|regulation of protein kinase activity|regulation of small GTPase mediated signal transduction|protein homooligomerization|regulation of attachment of spindle microtubules to kinetochore|cellular response to hydrogen peroxide|bicellular tight junction assembly|cellular response to calcium ion|cellular response to ionizing radiation|mitotic spindle|activation of GTPase activity|centralspindlin complex|regulation of cytokinesis, actomyosin contractile ring assembly" EDA 44.27231023 52.02069413 36.52392633 0.702103787 -0.510243786 0.42528933 1 0.243104101 0.167828139 1896 ectodysplasin A "GO:0005102,GO:0005123,GO:0005164,GO:0005515,GO:0005576,GO:0005581,GO:0005789,GO:0005811,GO:0005856,GO:0005886,GO:0005887,GO:0006955,GO:0007160,GO:0010467,GO:0010628,GO:0016020,GO:0016021,GO:0030154,GO:0033209,GO:0038177,GO:0042475,GO:0043123,GO:0043231,GO:0043473,GO:0045177,GO:0051092,GO:0060662,GO:0060789,GO:0061153,GO:0090263,GO:1901224" signaling receptor binding|death receptor binding|tumor necrosis factor receptor binding|protein binding|extracellular region|collagen trimer|endoplasmic reticulum membrane|lipid droplet|cytoskeleton|plasma membrane|integral component of plasma membrane|immune response|cell-matrix adhesion|gene expression|positive regulation of gene expression|membrane|integral component of membrane|cell differentiation|tumor necrosis factor-mediated signaling pathway|death receptor agonist activity|odontogenesis of dentin-containing tooth|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|pigmentation|apical part of cell|positive regulation of NF-kappaB transcription factor activity|salivary gland cavitation|hair follicle placode formation|trachea gland development|positive regulation of canonical Wnt signaling pathway|positive regulation of NIK/NF-kappaB signaling "hsa04060,hsa04064" Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway EDARADD 205.9585181 221.608157 190.3088793 0.858762971 -0.21966811 0.547283117 1 3.567668187 3.0125131 128178 EDAR associated death domain "GO:0005515,GO:0005829,GO:0007275,GO:0030154,GO:0033209,GO:1901224" protein binding|cytosol|multicellular organism development|cell differentiation|tumor necrosis factor-mediated signaling pathway|positive regulation of NIK/NF-kappaB signaling hsa04064 NF-kappa B signaling pathway EDC3 993.4573628 1037.292641 949.6220845 0.915481367 -0.127397573 0.606630324 1 11.13627073 10.02444802 80153 enhancer of mRNA decapping 3 "GO:0000932,GO:0003729,GO:0005515,GO:0005829,GO:0016020,GO:0031087,GO:0033962,GO:0036464,GO:0042802,GO:0043928,GO:0090502,GO:1990174" "P-body|mRNA binding|protein binding|cytosol|membrane|deadenylation-independent decapping of nuclear-transcribed mRNA|P-body assembly|cytoplasmic ribonucleoprotein granule|identical protein binding|exonucleolytic catabolism of deadenylated mRNA|RNA phosphodiester bond hydrolysis, endonucleolytic|phosphodiesterase decapping endonuclease activity" hsa03018 RNA degradation EDC4 1181.5307 1218.324657 1144.736744 0.939599094 -0.089882773 0.713210249 1 13.6395527 12.60125779 23644 enhancer of mRNA decapping 4 "GO:0000932,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008150,GO:0016020,GO:0031087,GO:0036464,GO:0043928" P-body|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|biological_process|membrane|deadenylation-independent decapping of nuclear-transcribed mRNA|cytoplasmic ribonucleoprotein granule|exonucleolytic catabolism of deadenylated mRNA hsa03018 RNA degradation EDEM1 3283.611148 3225.283036 3341.939259 1.036169298 0.051259742 0.82988298 1 24.40485295 24.86440628 9695 ER degradation enhancing alpha-mannosidase like protein 1 "GO:0004571,GO:0005509,GO:0005515,GO:0005783,GO:0005975,GO:0016235,GO:0030176,GO:0030433,GO:0036498,GO:0036510,GO:0044322,GO:0045047,GO:0051787,GO:0097466,GO:1904154,GO:1904382" "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|protein binding|endoplasmic reticulum|carbohydrate metabolic process|aggresome|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|IRE1-mediated unfolded protein response|trimming of terminal mannose on C branch|endoplasmic reticulum quality control compartment|protein targeting to ER|misfolded protein binding|ubiquitin-dependent glycoprotein ERAD pathway|positive regulation of retrograde protein transport, ER to cytosol|mannose trimming involved in glycoprotein ERAD pathway" hsa04141 Protein processing in endoplasmic reticulum EDEM2 8.848548421 5.202069413 12.49502743 2.401934007 1.264196513 0.321680077 1 0.14735928 0.348024438 55741 ER degradation enhancing alpha-mannosidase like protein 2 "GO:0004571,GO:0005509,GO:0005783,GO:0005788,GO:0005975,GO:0006986,GO:0016020,GO:0036509,GO:0036510,GO:0036511,GO:0036512,GO:0044322,GO:0097466,GO:1904154,GO:1904382" "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum lumen|carbohydrate metabolic process|response to unfolded protein|membrane|trimming of terminal mannose on B branch|trimming of terminal mannose on C branch|trimming of first mannose on A branch|trimming of second mannose on A branch|endoplasmic reticulum quality control compartment|ubiquitin-dependent glycoprotein ERAD pathway|positive regulation of retrograde protein transport, ER to cytosol|mannose trimming involved in glycoprotein ERAD pathway" hsa04141 Protein processing in endoplasmic reticulum EDEM3 999.5362998 1058.100919 940.9716809 0.889302395 -0.169254024 0.49251666 1 6.507883061 5.690630419 80267 ER degradation enhancing alpha-mannosidase like protein 3 "GO:0004571,GO:0005509,GO:0005788,GO:0005975,GO:0006486,GO:0006986,GO:0016020,GO:0044322,GO:1904382" "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum lumen|carbohydrate metabolic process|protein glycosylation|response to unfolded protein|membrane|endoplasmic reticulum quality control compartment|mannose trimming involved in glycoprotein ERAD pathway" hsa04141 Protein processing in endoplasmic reticulum EDF1 3109.731853 3101.473784 3117.989921 1.005325254 0.007662334 0.975705567 1 157.6380529 155.8256091 8721 endothelial differentiation related factor 1 "GO:0001094,GO:0003677,GO:0003713,GO:0003723,GO:0005515,GO:0005516,GO:0005622,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006355,GO:0007275,GO:0019216,GO:0043388,GO:0045446,GO:0045893" "TFIID-class transcription factor complex binding|DNA binding|transcription coactivator activity|RNA binding|protein binding|calmodulin binding|intracellular anatomical structure|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|regulation of transcription, DNA-templated|multicellular organism development|regulation of lipid metabolic process|positive regulation of DNA binding|endothelial cell differentiation|positive regulation of transcription, DNA-templated" EDIL3 316.6694762 276.7500928 356.5888597 1.288486866 0.365677831 0.238161003 1 3.076368216 3.897530212 10085 EGF like repeats and discoidin domains 3 "GO:0005178,GO:0005201,GO:0005509,GO:0007155,GO:0007275,GO:0010811,GO:0062023,GO:0070062,GO:1903561" integrin binding|extracellular matrix structural constituent|calcium ion binding|cell adhesion|multicellular organism development|positive regulation of cell-substrate adhesion|collagen-containing extracellular matrix|extracellular exosome|extracellular vesicle EDN1 166.3139646 114.4455271 218.182402 1.906430138 0.930873664 0.017440164 0.770503287 2.305680422 4.322063921 1906 endothelin 1 "GO:0000122,GO:0001516,GO:0001569,GO:0001701,GO:0001821,GO:0003100,GO:0005125,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0006874,GO:0006885,GO:0007166,GO:0007186,GO:0007193,GO:0007204,GO:0007205,GO:0007267,GO:0007507,GO:0007585,GO:0007589,GO:0008284,GO:0009953,GO:0010193,GO:0010259,GO:0010460,GO:0010595,GO:0010613,GO:0010827,GO:0014032,GO:0014065,GO:0014823,GO:0014824,GO:0014826,GO:0019229,GO:0019233,GO:0019722,GO:0030072,GO:0030133,GO:0030185,GO:0030195,GO:0030335,GO:0030593,GO:0031583,GO:0031707,GO:0031708,GO:0032269,GO:0032308,GO:0032496,GO:0033093,GO:0033574,GO:0034392,GO:0034696,GO:0035094,GO:0035690,GO:0035810,GO:0035815,GO:0035994,GO:0042045,GO:0042310,GO:0042313,GO:0042474,GO:0042482,GO:0042554,GO:0043179,GO:0043200,GO:0043406,GO:0043507,GO:0044321,GO:0045178,GO:0045321,GO:0045429,GO:0045793,GO:0045840,GO:0045944,GO:0045987,GO:0046887,GO:0046888,GO:0048016,GO:0048237,GO:0048661,GO:0051091,GO:0051216,GO:0051482,GO:0051771,GO:0051899,GO:0051930,GO:0060137,GO:0060298,GO:0060585,GO:0061051,GO:0070101,GO:0071277,GO:0071346,GO:0071347,GO:0071356,GO:0071375,GO:0071385,GO:0071389,GO:0071398,GO:0071456,GO:0071548,GO:0071560,GO:0086100,GO:0090023,GO:1901224,GO:1902074,GO:1904707,GO:2000273" negative regulation of transcription by RNA polymerase II|prostaglandin biosynthetic process|branching involved in blood vessel morphogenesis|in utero embryonic development|histamine secretion|regulation of systemic arterial blood pressure by endothelin|cytokine activity|hormone activity|protein binding|extracellular region|extracellular space|cytoplasm|cellular calcium ion homeostasis|regulation of pH|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|protein kinase C-activating G protein-coupled receptor signaling pathway|cell-cell signaling|heart development|respiratory gaseous exchange by respiratory system|body fluid secretion|positive regulation of cell population proliferation|dorsal/ventral pattern formation|response to ozone|multicellular organism aging|positive regulation of heart rate|positive regulation of endothelial cell migration|positive regulation of cardiac muscle hypertrophy|regulation of glucose transmembrane transport|neural crest cell development|phosphatidylinositol 3-kinase signaling|response to activity|artery smooth muscle contraction|vein smooth muscle contraction|regulation of vasoconstriction|sensory perception of pain|calcium-mediated signaling|peptide hormone secretion|transport vesicle|nitric oxide transport|negative regulation of blood coagulation|positive regulation of cell migration|neutrophil chemotaxis|phospholipase D-activating G protein-coupled receptor signaling pathway|endothelin A receptor binding|endothelin B receptor binding|negative regulation of cellular protein metabolic process|positive regulation of prostaglandin secretion|response to lipopolysaccharide|Weibel-Palade body|response to testosterone|negative regulation of smooth muscle cell apoptotic process|response to prostaglandin F|response to nicotine|cellular response to drug|positive regulation of urine volume|positive regulation of renal sodium excretion|response to muscle stretch|epithelial fluid transport|vasoconstriction|protein kinase C deactivation|middle ear morphogenesis|positive regulation of odontogenesis|superoxide anion generation|rhythmic excitation|response to amino acid|positive regulation of MAP kinase activity|positive regulation of JUN kinase activity|response to leptin|basal part of cell|leukocyte activation|positive regulation of nitric oxide biosynthetic process|positive regulation of cell size|positive regulation of mitotic nuclear division|positive regulation of transcription by RNA polymerase II|positive regulation of smooth muscle contraction|positive regulation of hormone secretion|negative regulation of hormone secretion|inositol phosphate-mediated signaling|rough endoplasmic reticulum lumen|positive regulation of smooth muscle cell proliferation|positive regulation of DNA-binding transcription factor activity|cartilage development|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|negative regulation of nitric-oxide synthase biosynthetic process|membrane depolarization|regulation of sensory perception of pain|maternal process involved in parturition|positive regulation of sarcomere organization|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of cell growth involved in cardiac muscle cell development|positive regulation of chemokine-mediated signaling pathway|cellular response to calcium ion|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to peptide hormone stimulus|cellular response to glucocorticoid stimulus|cellular response to mineralocorticoid stimulus|cellular response to fatty acid|cellular response to hypoxia|response to dexamethasone|cellular response to transforming growth factor beta stimulus|endothelin receptor signaling pathway|positive regulation of neutrophil chemotaxis|positive regulation of NIK/NF-kappaB signaling|response to salt|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of signaling receptor activity "hsa04024,hsa04066,hsa04080,hsa04270,hsa04668,hsa04916,hsa04924,hsa04926,hsa04933,hsa05200,hsa05410,hsa05418" cAMP signaling pathway|HIF-1 signaling pathway|Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction|TNF signaling pathway|Melanogenesis|Renin secretion|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Pathways in cancer|Hypertrophic cardiomyopathy|Fluid shear stress and atherosclerosis EDNRA 196.8816424 286.1138177 107.6494671 0.376247005 -1.410247996 0.000144999 0.048362429 3.039285151 1.124386645 1909 endothelin receptor type A "GO:0001569,GO:0001666,GO:0001701,GO:0004435,GO:0004962,GO:0005515,GO:0005886,GO:0005887,GO:0006939,GO:0007165,GO:0007186,GO:0007190,GO:0007193,GO:0007202,GO:0007204,GO:0007507,GO:0007585,GO:0008217,GO:0008283,GO:0010827,GO:0014032,GO:0014824,GO:0042310,GO:0048484,GO:0060322,GO:0086100" branching involved in blood vessel morphogenesis|response to hypoxia|in utero embryonic development|phosphatidylinositol phospholipase C activity|endothelin receptor activity|protein binding|plasma membrane|integral component of plasma membrane|smooth muscle contraction|signal transduction|G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|activation of phospholipase C activity|positive regulation of cytosolic calcium ion concentration|heart development|respiratory gaseous exchange by respiratory system|regulation of blood pressure|cell population proliferation|regulation of glucose transmembrane transport|neural crest cell development|artery smooth muscle contraction|vasoconstriction|enteric nervous system development|head development|endothelin receptor signaling pathway "hsa04020,hsa04022,hsa04024,hsa04080,hsa04270,hsa04924,hsa05200" Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction|Renin secretion|Pathways in cancer EDRF1 342.5112466 349.5790646 335.4434286 0.959563837 -0.059549306 0.852921204 1 4.102109098 3.870367976 26098 erythroid differentiation regulatory factor 1 "GO:0005515,GO:0005575,GO:0005634,GO:0045893" "protein binding|cellular_component|nucleus|positive regulation of transcription, DNA-templated" EEA1 863.3106639 913.483389 813.1379388 0.890150766 -0.167878386 0.502593578 1 4.805888166 4.206379083 8411 early endosome antigen 1 "GO:0005515,GO:0005516,GO:0005545,GO:0005737,GO:0005769,GO:0005829,GO:0005969,GO:0006897,GO:0006906,GO:0008270,GO:0016020,GO:0016189,GO:0019897,GO:0030742,GO:0031901,GO:0039694,GO:0042803,GO:0044308,GO:0045022,GO:0055037,GO:0070062" protein binding|calmodulin binding|1-phosphatidylinositol binding|cytoplasm|early endosome|cytosol|serine-pyruvate aminotransferase complex|endocytosis|vesicle fusion|zinc ion binding|membrane|synaptic vesicle to endosome fusion|extrinsic component of plasma membrane|GTP-dependent protein binding|early endosome membrane|viral RNA genome replication|protein homodimerization activity|axonal spine|early endosome to late endosome transport|recycling endosome|extracellular exosome "hsa04144,hsa04145,hsa05152" Endocytosis|Phagosome|Tuberculosis EED 658.6504551 650.2586767 667.0422335 1.025810585 0.036764363 0.89287869 1 10.16494155 10.25281781 8726 embryonic ectoderm development "GO:0000122,GO:0001226,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006342,GO:0016032,GO:0031491,GO:0035098,GO:0042054,GO:0042802,GO:0045814,GO:0045892,GO:0046976,GO:0070317,GO:0070734" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription corepressor binding|protein binding|nucleus|nucleoplasm|chromosome|cytosol|chromatin silencing|viral process|nucleosome binding|ESC/E(Z) complex|histone methyltransferase activity|identical protein binding|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|histone methyltransferase activity (H3-K27 specific)|negative regulation of G0 to G1 transition|histone H3-K27 methylation" chromosome_remodelling_factor EEF1A1 241041.2149 251069.5569 231012.8729 0.92011503 -0.120113861 0.815871907 1 3815.23941 3451.716344 1915 eukaryotic translation elongation factor 1 alpha 1 "GO:0000049,GO:0003723,GO:0003746,GO:0003924,GO:0005515,GO:0005516,GO:0005525,GO:0005576,GO:0005615,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005853,GO:0005886,GO:0006412,GO:0006414,GO:0016020,GO:0019900,GO:0019901,GO:0030864,GO:0032587,GO:0034774,GO:0043312,GO:0070062,GO:0071364,GO:0098574,GO:1900022,GO:1904714,GO:1904813" tRNA binding|RNA binding|translation elongation factor activity|GTPase activity|protein binding|calmodulin binding|GTP binding|extracellular region|extracellular space|nucleus|nucleolus|cytoplasm|cytosol|eukaryotic translation elongation factor 1 complex|plasma membrane|translation|translational elongation|membrane|kinase binding|protein kinase binding|cortical actin cytoskeleton|ruffle membrane|secretory granule lumen|neutrophil degranulation|extracellular exosome|cellular response to epidermal growth factor stimulus|cytoplasmic side of lysosomal membrane|regulation of D-erythro-sphingosine kinase activity|regulation of chaperone-mediated autophagy|ficolin-1-rich granule lumen "hsa03013,hsa05134,hsa05140" RNA transport|Legionellosis|Leishmaniasis EEF1A2 1685.94765 1490.913094 1880.982206 1.261631019 0.335290036 0.158151763 1 44.87720904 55.67104541 1917 eukaryotic translation elongation factor 1 alpha 2 "GO:0003746,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005853,GO:0006412,GO:0006414,GO:0008135,GO:0010035,GO:0019901,GO:0043025,GO:0043065,GO:0045202,GO:0051602,GO:0090218,GO:0098574,GO:1904714" "translation elongation factor activity|GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|eukaryotic translation elongation factor 1 complex|translation|translational elongation|translation factor activity, RNA binding|response to inorganic substance|protein kinase binding|neuronal cell body|positive regulation of apoptotic process|synapse|response to electrical stimulus|positive regulation of lipid kinase activity|cytoplasmic side of lysosomal membrane|regulation of chaperone-mediated autophagy" "hsa03013,hsa05134,hsa05140" RNA transport|Legionellosis|Leishmaniasis EEF1AKMT1 90.11530212 82.19269673 98.03790751 1.19278125 0.254329484 0.613370864 1 3.495197738 4.09924365 221143 EEF1A lysine methyltransferase 1 "GO:0003676,GO:0005829,GO:0006479,GO:0008168,GO:0016279,GO:0018022" nucleic acid binding|cytosol|protein methylation|methyltransferase activity|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation EEF1AKMT2 283.4749972 263.2247123 303.7252821 1.153863098 0.206472064 0.525661167 1 3.898922872 4.423541512 399818 EEF1A lysine methyltransferase 2 "GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006479,GO:0008168,GO:0016279,GO:0016604,GO:0018022,GO:0018026,GO:0018027,GO:0043231" nucleus|nucleoplasm|cytoplasm|cytosol|protein methylation|methyltransferase activity|protein-lysine N-methyltransferase activity|nuclear body|peptidyl-lysine methylation|peptidyl-lysine monomethylation|peptidyl-lysine dimethylation|intracellular membrane-bounded organelle EEF1AKMT3 301.4790649 306.9220954 296.0360344 0.964531518 -0.052099713 0.878642618 1 5.796131681 5.497001376 25895 EEF1A lysine methyltransferase 3 "GO:0005515,GO:0005654,GO:0005694,GO:0005737,GO:0005813,GO:0005829,GO:0008168,GO:0016279,GO:0018022,GO:0031072,GO:0032991" protein binding|nucleoplasm|chromosome|cytoplasm|centrosome|cytosol|methyltransferase activity|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation|heat shock protein binding|protein-containing complex EEF1AKMT4 27.06082178 29.13158871 24.99005486 0.857833574 -0.221230314 0.811622748 1 1.594563434 1.344980596 110599564 EEF1A lysine methyltransferase 4 "GO:0008168,GO:0016279,GO:0018022" methyltransferase activity|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation EEF1AKNMT 773.5916514 841.6948311 705.4884717 0.838176077 -0.254674749 0.314068891 1 14.76165171 12.16582021 51603 eEF1A lysine and N-terminal methyltransferase "GO:0005515,GO:0008168,GO:0032259" protein binding|methyltransferase activity|methylation EEF1B2 6555.723022 6464.091453 6647.354592 1.028350951 0.040332705 0.868934415 1 390.2451135 394.593572 1933 eukaryotic translation elongation factor 1 beta 2 "GO:0003746,GO:0005085,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0005853,GO:0006414,GO:0050790" translation elongation factor activity|guanyl-nucleotide exchange factor activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum|cytosol|eukaryotic translation elongation factor 1 complex|translational elongation|regulation of catalytic activity EEF1D 9289.673079 9490.655437 9088.69072 0.957646264 -0.062435245 0.8028067 1 128.0007171 120.5282081 1936 eukaryotic translation elongation factor 1 delta "GO:0001650,GO:0003677,GO:0003746,GO:0005085,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0005853,GO:0006414,GO:0008135,GO:0043123,GO:0045296,GO:0050790,GO:0071479" "fibrillar center|DNA binding|translation elongation factor activity|guanyl-nucleotide exchange factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|eukaryotic translation elongation factor 1 complex|translational elongation|translation factor activity, RNA binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|cadherin binding|regulation of catalytic activity|cellular response to ionizing radiation" EEF1E1 839.5402748 768.8658593 910.2146903 1.183840691 0.243474951 0.331249474 1 34.25121686 39.86946864 9521 eukaryotic translation elongation factor 1 epsilon 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006418,GO:0008285,GO:0017101,GO:0043065,GO:0043517,GO:2000774" "protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|tRNA aminoacylation for protein translation|negative regulation of cell population proliferation|aminoacyl-tRNA synthetase multienzyme complex|positive regulation of apoptotic process|positive regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of cellular senescence" EEF1G 41849.57759 43122.03419 40577.12099 0.940983461 -0.087758728 0.779583557 1 1591.524004 1472.537496 1937 eukaryotic translation elongation factor 1 gamma "GO:0003746,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0006414,GO:0006749,GO:0009615,GO:0016020,GO:0045296,GO:0070062" translation elongation factor activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum|cytosol|translational elongation|glutathione metabolic process|response to virus|membrane|cadherin binding|extracellular exosome hsa05134 Legionellosis EEF2 64788.08381 71751.103 57825.06462 0.805911856 -0.311306037 0.369352142 1 1212.547338 960.8540528 1938 eukaryotic translation elongation factor 2 "GO:0002039,GO:0002244,GO:0002931,GO:0003009,GO:0003723,GO:0003746,GO:0003924,GO:0005515,GO:0005525,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006414,GO:0007568,GO:0008097,GO:0014009,GO:0016020,GO:0016235,GO:0019901,GO:0032355,GO:0034774,GO:0034976,GO:0035914,GO:0042493,GO:0042542,GO:0042788,GO:0043022,GO:0043312,GO:0045121,GO:0045202,GO:0045296,GO:0045471,GO:0045727,GO:0051015,GO:0051593,GO:0070062,GO:1904813,GO:1990416,GO:1990904,GO:2000767" p53 binding|hematopoietic progenitor cell differentiation|response to ischemia|skeletal muscle contraction|RNA binding|translation elongation factor activity|GTPase activity|protein binding|GTP binding|extracellular region|nucleus|cytoplasm|cytosol|plasma membrane|translational elongation|aging|5S rRNA binding|glial cell proliferation|membrane|aggresome|protein kinase binding|response to estradiol|secretory granule lumen|response to endoplasmic reticulum stress|skeletal muscle cell differentiation|response to drug|response to hydrogen peroxide|polysomal ribosome|ribosome binding|neutrophil degranulation|membrane raft|synapse|cadherin binding|response to ethanol|positive regulation of translation|actin filament binding|response to folic acid|extracellular exosome|ficolin-1-rich granule lumen|cellular response to brain-derived neurotrophic factor stimulus|ribonucleoprotein complex|positive regulation of cytoplasmic translation "hsa04152,hsa04921" AMPK signaling pathway|Oxytocin signaling pathway EEF2K 868.5724839 874.9880753 862.1568925 0.985335591 -0.021312925 0.936762803 1 8.633112483 8.364168018 29904 eukaryotic elongation factor 2 kinase "GO:0002931,GO:0004672,GO:0004686,GO:0005509,GO:0005516,GO:0005524,GO:0005737,GO:0005829,GO:0006414,GO:0008135,GO:0014069,GO:0031952,GO:0032869,GO:0043066,GO:0043197,GO:0045807,GO:0046777,GO:0051965,GO:0061003,GO:0071277,GO:0071320,GO:0071454,GO:1990416,GO:1990637" "response to ischemia|protein kinase activity|elongation factor-2 kinase activity|calcium ion binding|calmodulin binding|ATP binding|cytoplasm|cytosol|translational elongation|translation factor activity, RNA binding|postsynaptic density|regulation of protein autophosphorylation|cellular response to insulin stimulus|negative regulation of apoptotic process|dendritic spine|positive regulation of endocytosis|protein autophosphorylation|positive regulation of synapse assembly|positive regulation of dendritic spine morphogenesis|cellular response to calcium ion|cellular response to cAMP|cellular response to anoxia|cellular response to brain-derived neurotrophic factor stimulus|response to prolactin" "hsa04152,hsa04921" AMPK signaling pathway|Oxytocin signaling pathway EEF2KMT 204.754558 227.8506403 181.6584757 0.797269981 -0.326859745 0.366850974 1 4.927054255 3.862459472 196483 eukaryotic elongation factor 2 lysine methyltransferase "GO:0005515,GO:0005737,GO:0005829,GO:0006479,GO:0016279,GO:0018023,GO:0032991" protein binding|cytoplasm|cytosol|protein methylation|protein-lysine N-methyltransferase activity|peptidyl-lysine trimethylation|protein-containing complex EEFSEC 225.2458039 261.1438845 189.3477233 0.725070486 -0.463806844 0.182243263 1 3.429323119 2.444892755 60678 "eukaryotic elongation factor, selenocysteine-tRNA specific" "GO:0000049,GO:0001514,GO:0003746,GO:0003924,GO:0005525,GO:0005634,GO:0005737,GO:0006414,GO:0035368,GO:0043021,GO:1990904" tRNA binding|selenocysteine incorporation|translation elongation factor activity|GTPase activity|GTP binding|nucleus|cytoplasm|translational elongation|selenocysteine insertion sequence binding|ribonucleoprotein complex binding|ribonucleoprotein complex EEPD1 48.35470783 58.26317743 38.44623824 0.65987198 -0.599741937 0.327997736 1 0.384541021 0.249501718 80820 endonuclease/exonuclease/phosphatase family domain containing 1 "GO:0003677,GO:0005515,GO:0006281,GO:0010875,GO:0046658" DNA binding|protein binding|DNA repair|positive regulation of cholesterol efflux|anchored component of plasma membrane EFCAB1 40.9132948 39.53572754 42.29086206 1.069687209 0.097188995 0.919794412 1 0.305258842 0.321067417 79645 EF-hand calcium binding domain 1 GO:0005509 calcium ion binding EFCAB11 341.0248533 361.0236173 321.0260893 0.889210772 -0.16940267 0.580600919 1 4.04432555 3.536079339 90141 EF-hand calcium binding domain 11 "GO:0005509,GO:0005515" calcium ion binding|protein binding EFCAB12 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.029581767 0.008956983 90288 EF-hand calcium binding domain 12 "GO:0005509,GO:0005515" calcium ion binding|protein binding EFCAB13 16.73091047 22.88910542 10.57271552 0.461910386 -1.11431511 0.229652802 1 0.259572777 0.117893008 124989 EF-hand calcium binding domain 13 EFCAB14 2786.453172 2827.844933 2745.06141 0.970725579 -0.042864587 0.857553851 1 25.9441098 24.76318065 9813 EF-hand calcium binding domain 14 GO:0005509 calcium ion binding EFCAB2 18.57396445 20.80827765 16.33965125 0.785247656 -0.348780364 0.735839075 1 0.080076401 0.061827598 84288 EF-hand calcium binding domain 2 "GO:0005509,GO:0005737,GO:0005856,GO:0031514" calcium ion binding|cytoplasm|cytoskeleton|motile cilium EFCAB5 9.606529142 12.48496659 6.728091692 0.53889545 -0.891922689 0.47680615 1 0.10092392 0.053477341 374786 EF-hand calcium binding domain 5 GO:0005509 calcium ion binding EFCAB7 224.7803172 223.6889848 225.8716497 1.009757588 0.014008987 0.982372559 1 2.470074487 2.45243979 84455 EF-hand calcium binding domain 7 "GO:0005509,GO:0005929,GO:0019898,GO:0042307,GO:0045944,GO:0060170,GO:0098797,GO:1903569" calcium ion binding|cilium|extrinsic component of membrane|positive regulation of protein import into nucleus|positive regulation of transcription by RNA polymerase II|ciliary membrane|plasma membrane protein complex|positive regulation of protein localization to ciliary membrane EFCAB8 58.41224683 44.73779695 72.0866967 1.6113153 0.688238826 0.227138869 1 0.245458415 0.38889256 388795 EF-hand calcium binding domain 8 GO:0005509 calcium ion binding EFEMP1 2069.062148 2351.335375 1786.788922 0.7599039 -0.396111112 0.094042719 1 41.71756894 31.1708643 2202 EGF containing fibulin extracellular matrix protein 1 "GO:0005006,GO:0005154,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0006355,GO:0007173,GO:0007601,GO:0008083,GO:0018108,GO:0031012,GO:0032331,GO:0043010,GO:0048048,GO:0048050,GO:0062023,GO:0070062" "epidermal growth factor-activated receptor activity|epidermal growth factor receptor binding|extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|extracellular space|regulation of transcription, DNA-templated|epidermal growth factor receptor signaling pathway|visual perception|growth factor activity|peptidyl-tyrosine phosphorylation|extracellular matrix|negative regulation of chondrocyte differentiation|camera-type eye development|embryonic eye morphogenesis|post-embryonic eye morphogenesis|collagen-containing extracellular matrix|extracellular exosome" EFEMP2 1332.084971 1284.911145 1379.258797 1.073427374 0.102224585 0.672449651 1 35.45674573 37.42335488 30008 EGF containing fibulin extracellular matrix protein 2 "GO:0001527,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005604,GO:0008201,GO:0031012,GO:0035904,GO:0042803,GO:0048251,GO:0060414,GO:0062023,GO:0070062,GO:0071953,GO:0097084,GO:1903561,GO:1904026,GO:1904028,GO:1904706,GO:1904831,GO:1905609" microfibril|extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|basement membrane|heparin binding|extracellular matrix|aorta development|protein homodimerization activity|elastic fiber assembly|aorta smooth muscle tissue morphogenesis|collagen-containing extracellular matrix|extracellular exosome|elastic fiber|vascular associated smooth muscle cell development|extracellular vesicle|regulation of collagen fibril organization|positive regulation of collagen fibril organization|negative regulation of vascular associated smooth muscle cell proliferation|positive regulation of aortic smooth muscle cell differentiation|positive regulation of smooth muscle cell-matrix adhesion EFHB 8.045908318 9.363724944 6.728091692 0.718527267 -0.476885189 0.786592357 1 0.14196727 0.1003004 151651 EF-hand domain family member B "GO:0005515,GO:0005737,GO:0006816,GO:0032091,GO:0061891,GO:0070884,GO:2001256" protein binding|cytoplasm|calcium ion transport|negative regulation of protein binding|calcium ion sensor activity|regulation of calcineurin-NFAT signaling cascade|regulation of store-operated calcium entry EFHC1 729.3891526 715.8047513 742.973554 1.037955605 0.053744739 0.837826822 1 5.427846545 5.539588667 114327 EF-hand domain containing 1 "GO:0000281,GO:0000922,GO:0005509,GO:0005515,GO:0005813,GO:0005930,GO:0007052,GO:0008022,GO:0021795,GO:0043014,GO:0043025,GO:0051302,GO:0060285,GO:0072686" mitotic cytokinesis|spindle pole|calcium ion binding|protein binding|centrosome|axoneme|mitotic spindle organization|protein C-terminus binding|cerebral cortex cell migration|alpha-tubulin binding|neuronal cell body|regulation of cell division|cilium-dependent cell motility|mitotic spindle EFHD2 3361.722675 3181.585653 3541.859698 1.113237261 0.154761103 0.514387627 1 70.10544129 76.73802896 79180 EF-hand domain family member D2 "GO:0005509,GO:0045121,GO:0045296" calcium ion binding|membrane raft|cadherin binding EFL1 1364.47681 1302.598181 1426.355439 1.095008007 0.13094142 0.586655515 1 16.82819435 18.11865654 79631 elongation factor like GTPase 1 "GO:0003746,GO:0003924,GO:0005525,GO:0005829,GO:0006414,GO:0042256,GO:0043022,GO:0046039,GO:1990904" translation elongation factor activity|GTPase activity|GTP binding|cytosol|translational elongation|mature ribosome assembly|ribosome binding|GTP metabolic process|ribonucleoprotein complex hsa03008 Ribosome biogenesis in eukaryotes EFNA1 173.0018129 214.3252598 131.678366 0.614385659 -0.702783554 0.067188005 1 7.36993892 4.452215086 1942 ephrin A1 "GO:0000122,GO:0001525,GO:0001934,GO:0003180,GO:0003183,GO:0003199,GO:0005102,GO:0005515,GO:0005576,GO:0005886,GO:0007267,GO:0007411,GO:0010719,GO:0014028,GO:0016477,GO:0033628,GO:0034446,GO:0043409,GO:0043410,GO:0043535,GO:0045765,GO:0046658,GO:0046875,GO:0048013,GO:0050730,GO:0050731,GO:0050770,GO:0050821,GO:0061002,GO:0061098,GO:0070244,GO:1902004,GO:1902961,GO:1903051" negative regulation of transcription by RNA polymerase II|angiogenesis|positive regulation of protein phosphorylation|aortic valve morphogenesis|mitral valve morphogenesis|endocardial cushion to mesenchymal transition involved in heart valve formation|signaling receptor binding|protein binding|extracellular region|plasma membrane|cell-cell signaling|axon guidance|negative regulation of epithelial to mesenchymal transition|notochord formation|cell migration|regulation of cell adhesion mediated by integrin|substrate adhesion-dependent cell spreading|negative regulation of MAPK cascade|positive regulation of MAPK cascade|regulation of blood vessel endothelial cell migration|regulation of angiogenesis|anchored component of plasma membrane|ephrin receptor binding|ephrin receptor signaling pathway|regulation of peptidyl-tyrosine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|regulation of axonogenesis|protein stabilization|negative regulation of dendritic spine morphogenesis|positive regulation of protein tyrosine kinase activity|negative regulation of thymocyte apoptotic process|positive regulation of amyloid-beta formation|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of proteolysis involved in cellular protein catabolic process "hsa04010,hsa04014,hsa04015,hsa04151,hsa04360,hsa05206" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Axon guidance|MicroRNAs in cancer EFNA3 75.18278626 68.66731625 81.69825626 1.189769176 0.250681707 0.644002805 1 2.016867619 2.359452752 1944 ephrin A3 "GO:0005005,GO:0005515,GO:0005886,GO:0007267,GO:0007411,GO:0016525,GO:0031225,GO:0031226,GO:0045664,GO:0046875,GO:0048013,GO:1902961" transmembrane-ephrin receptor activity|protein binding|plasma membrane|cell-cell signaling|axon guidance|negative regulation of angiogenesis|anchored component of membrane|intrinsic component of plasma membrane|regulation of neuron differentiation|ephrin receptor binding|ephrin receptor signaling pathway|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process "hsa04010,hsa04014,hsa04015,hsa04151,hsa04360,hsa05206" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Axon guidance|MicroRNAs in cancer EFNA4 197.9968982 201.8402932 194.1535031 0.961916474 -0.056016469 0.891814843 1 8.589988424 8.124583746 1945 ephrin A4 "GO:0005005,GO:0005515,GO:0005576,GO:0005886,GO:0007267,GO:0007411,GO:0031225,GO:0031226,GO:0046875,GO:0048013" transmembrane-ephrin receptor activity|protein binding|extracellular region|plasma membrane|cell-cell signaling|axon guidance|anchored component of membrane|intrinsic component of plasma membrane|ephrin receptor binding|ephrin receptor signaling pathway "hsa04010,hsa04014,hsa04015,hsa04151,hsa04360,hsa05206" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Axon guidance|MicroRNAs in cancer EFNA5 424.2290102 400.5593448 447.8986755 1.118183064 0.161156399 0.575629818 1 2.422336095 2.663290189 1946 ephrin A5 "GO:0001934,GO:0005168,GO:0005169,GO:0005170,GO:0005515,GO:0005886,GO:0005901,GO:0006915,GO:0007171,GO:0007399,GO:0007411,GO:0022407,GO:0022604,GO:0030297,GO:0031362,GO:0032956,GO:0043087,GO:0046875,GO:0048013,GO:0050731,GO:0051893,GO:0061178,GO:0070507,GO:1900025" positive regulation of protein phosphorylation|neurotrophin TRKA receptor binding|neurotrophin TRKB receptor binding|neurotrophin TRKC receptor binding|protein binding|plasma membrane|caveola|apoptotic process|activation of transmembrane receptor protein tyrosine kinase activity|nervous system development|axon guidance|regulation of cell-cell adhesion|regulation of cell morphogenesis|transmembrane receptor protein tyrosine kinase activator activity|anchored component of external side of plasma membrane|regulation of actin cytoskeleton organization|regulation of GTPase activity|ephrin receptor binding|ephrin receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|regulation of focal adhesion assembly|regulation of insulin secretion involved in cellular response to glucose stimulus|regulation of microtubule cytoskeleton organization|negative regulation of substrate adhesion-dependent cell spreading "hsa04010,hsa04014,hsa04015,hsa04151,hsa04360,hsa05206" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Axon guidance|MicroRNAs in cancer EFNB1 230.066675 223.6889848 236.4443652 1.057022837 0.080006546 0.828120753 1 3.614250679 3.756417197 1947 ephrin B1 "GO:0001755,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0005887,GO:0007155,GO:0007267,GO:0007411,GO:0009880,GO:0031295,GO:0042102,GO:0045121,GO:0045202,GO:0046875,GO:0048013,GO:0070062" neural crest cell migration|protein binding|nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|cell adhesion|cell-cell signaling|axon guidance|embryonic pattern specification|T cell costimulation|positive regulation of T cell proliferation|membrane raft|synapse|ephrin receptor binding|ephrin receptor signaling pathway|extracellular exosome hsa04360 Axon guidance EFNB2 919.9100392 885.3922141 954.4278643 1.077971829 0.108319476 0.664785451 1 3.265272282 3.46097125 1948 ephrin B2 "GO:0001618,GO:0002042,GO:0005515,GO:0005886,GO:0005887,GO:0005912,GO:0005925,GO:0007155,GO:0007267,GO:0007411,GO:0008284,GO:0009653,GO:0010977,GO:0046718,GO:0046875,GO:0048013,GO:0048514,GO:0050920,GO:0098978,GO:0099054,GO:0099056,GO:1901216,GO:2000727" virus receptor activity|cell migration involved in sprouting angiogenesis|protein binding|plasma membrane|integral component of plasma membrane|adherens junction|focal adhesion|cell adhesion|cell-cell signaling|axon guidance|positive regulation of cell population proliferation|anatomical structure morphogenesis|negative regulation of neuron projection development|viral entry into host cell|ephrin receptor binding|ephrin receptor signaling pathway|blood vessel morphogenesis|regulation of chemotaxis|glutamatergic synapse|presynapse assembly|integral component of presynaptic membrane|positive regulation of neuron death|positive regulation of cardiac muscle cell differentiation hsa04360 Axon guidance EFNB3 200.4941372 166.4662212 234.5220533 1.408826677 0.494494133 0.173821555 1 2.762436653 3.82667054 1949 ephrin B3 "GO:0001618,GO:0005005,GO:0005515,GO:0005886,GO:0005887,GO:0007267,GO:0007399,GO:0007411,GO:0007628,GO:0016198,GO:0031295,GO:0046718,GO:0046875,GO:0048013,GO:0050771,GO:0098686,GO:0098978,GO:0099056,GO:0099061,GO:0099557" "virus receptor activity|transmembrane-ephrin receptor activity|protein binding|plasma membrane|integral component of plasma membrane|cell-cell signaling|nervous system development|axon guidance|adult walking behavior|axon choice point recognition|T cell costimulation|viral entry into host cell|ephrin receptor binding|ephrin receptor signaling pathway|negative regulation of axonogenesis|hippocampal mossy fiber to CA3 synapse|glutamatergic synapse|integral component of presynaptic membrane|integral component of postsynaptic density membrane|trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission" hsa04360 Axon guidance EFR3A 2966.365515 3185.747309 2746.983722 0.862272948 -0.213783476 0.366550941 1 30.63377995 25.97266584 23167 EFR3 homolog A "GO:0005829,GO:0005886,GO:0046854,GO:0072659" cytosol|plasma membrane|phosphatidylinositol phosphorylation|protein localization to plasma membrane EFR3B 37.91094004 36.41448589 39.4073942 1.082190047 0.113953878 0.904244363 1 0.252714458 0.268908669 22979 EFR3 homolog B "GO:0005515,GO:0005829,GO:0005886,GO:0015629,GO:0046854,GO:0072659" protein binding|cytosol|plasma membrane|actin cytoskeleton|phosphatidylinositol phosphorylation|protein localization to plasma membrane EFTUD2 3322.510969 3590.468309 3054.553628 0.850739615 -0.233210459 0.325395175 1 40.59675734 33.95933529 9343 elongation factor Tu GTP binding domain containing 2 "GO:0000398,GO:0003723,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005829,GO:0015030,GO:0016020,GO:0016607,GO:0030623,GO:0035690,GO:0042220,GO:0043231,GO:0046540,GO:0071005,GO:0071007,GO:0071013,GO:1990904" "mRNA splicing, via spliceosome|RNA binding|GTPase activity|protein binding|GTP binding|nucleus|nucleoplasm|cytosol|Cajal body|membrane|nuclear speck|U5 snRNA binding|cellular response to drug|response to cocaine|intracellular membrane-bounded organelle|U4/U6 x U5 tri-snRNP complex|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|ribonucleoprotein complex" hsa03040 Spliceosome EGF 15.69049658 20.80827765 10.57271552 0.508101424 -0.976811586 0.309335093 1 0.182918718 0.091386015 1950 epidermal growth factor "GO:0000165,GO:0000186,GO:0000187,GO:0001525,GO:0001938,GO:0002092,GO:0002576,GO:0005085,GO:0005154,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005765,GO:0005886,GO:0007165,GO:0007171,GO:0007173,GO:0008083,GO:0008284,GO:0010595,GO:0010628,GO:0010800,GO:0014068,GO:0016021,GO:0018108,GO:0021940,GO:0030297,GO:0030335,GO:0030665,GO:0031093,GO:0038029,GO:0038128,GO:0042059,GO:0042327,GO:0043388,GO:0043406,GO:0043410,GO:0045740,GO:0045741,GO:0045746,GO:0045840,GO:0045893,GO:0046425,GO:0048754,GO:0051048,GO:0051897,GO:0060749,GO:0061024,GO:0070062,GO:0070371,GO:0090263,GO:0090279,GO:0090370,GO:1900127,GO:1901185,GO:1902966,GO:1905278,GO:2000008,GO:2000060,GO:2000145" "MAPK cascade|activation of MAPKK activity|activation of MAPK activity|angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of receptor internalization|platelet degranulation|guanyl-nucleotide exchange factor activity|epidermal growth factor receptor binding|calcium ion binding|protein binding|extracellular region|extracellular space|lysosomal membrane|plasma membrane|signal transduction|activation of transmembrane receptor protein tyrosine kinase activity|epidermal growth factor receptor signaling pathway|growth factor activity|positive regulation of cell population proliferation|positive regulation of endothelial cell migration|positive regulation of gene expression|positive regulation of peptidyl-threonine phosphorylation|positive regulation of phosphatidylinositol 3-kinase signaling|integral component of membrane|peptidyl-tyrosine phosphorylation|positive regulation of cerebellar granule cell precursor proliferation|transmembrane receptor protein tyrosine kinase activator activity|positive regulation of cell migration|clathrin-coated vesicle membrane|platelet alpha granule lumen|epidermal growth factor receptor signaling pathway via MAPK cascade|ERBB2 signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphorylation|positive regulation of DNA binding|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|positive regulation of DNA replication|positive regulation of epidermal growth factor-activated receptor activity|negative regulation of Notch signaling pathway|positive regulation of mitotic nuclear division|positive regulation of transcription, DNA-templated|regulation of receptor signaling pathway via JAK-STAT|branching morphogenesis of an epithelial tube|negative regulation of secretion|positive regulation of protein kinase B signaling|mammary gland alveolus development|membrane organization|extracellular exosome|ERK1 and ERK2 cascade|positive regulation of canonical Wnt signaling pathway|regulation of calcium ion import|negative regulation of cholesterol efflux|positive regulation of hyaluronan biosynthetic process|negative regulation of ERBB signaling pathway|positive regulation of protein localization to early endosome|positive regulation of epithelial tube formation|regulation of protein localization to cell surface|positive regulation of ubiquitin-dependent protein catabolic process|regulation of cell motility" "hsa01521,hsa04010,hsa04012,hsa04014,hsa04015,hsa04020,hsa04066,hsa04068,hsa04072,hsa04151,hsa04510,hsa04540,hsa04630,hsa04810,hsa05160,hsa05165,hsa05200,hsa05210,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05219,hsa05223,hsa05224,hsa05226,hsa05231,hsa05235" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|JAK-STAT signaling pathway|Regulation of actin cytoskeleton|Hepatitis C|Human papillomavirus infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Non-small cell lung cancer|Breast cancer|Gastric cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer EGFL7 209.8427709 222.6485709 197.036971 0.884968496 -0.176301997 0.629182781 1 4.376554334 3.808301412 51162 EGF like domain multiple 7 "GO:0001525,GO:0001568,GO:0001570,GO:0001938,GO:0005102,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0007155,GO:0009986,GO:0045746,GO:0048856,GO:0062023" angiogenesis|blood vessel development|vasculogenesis|positive regulation of endothelial cell proliferation|signaling receptor binding|calcium ion binding|protein binding|extracellular region|extracellular space|cell adhesion|cell surface|negative regulation of Notch signaling pathway|anatomical structure development|collagen-containing extracellular matrix EGFL8 106.8411822 117.5667687 96.1155956 0.817540506 -0.290637883 0.533769814 1 4.833838497 3.885729766 80864 EGF like domain multiple 8 "GO:0001701,GO:0005102,GO:0005509,GO:0005515,GO:0005576,GO:0009986,GO:0048856" in utero embryonic development|signaling receptor binding|calcium ion binding|protein binding|extracellular region|cell surface|anatomical structure development EGFLAM 99.20665474 81.15228285 117.2610266 1.444950438 0.531020009 0.260141536 1 0.82841396 1.176986654 133584 "EGF like, fibronectin type III and laminin G domains" "GO:0005509,GO:0005539,GO:0005604,GO:0005614,GO:0009887,GO:0009888,GO:0010811,GO:0019800,GO:0030198,GO:0042995,GO:0043083,GO:0048786" calcium ion binding|glycosaminoglycan binding|basement membrane|interstitial matrix|animal organ morphogenesis|tissue development|positive regulation of cell-substrate adhesion|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|extracellular matrix organization|cell projection|synaptic cleft|presynaptic active zone EGFR 16453.25102 19523.36651 13383.13553 0.685493228 -0.544785681 0.040822133 1 95.86219414 64.61326878 1956 epidermal growth factor receptor "GO:0000139,GO:0000165,GO:0000186,GO:0001503,GO:0001618,GO:0001934,GO:0001942,GO:0003682,GO:0003690,GO:0004709,GO:0004713,GO:0004714,GO:0004888,GO:0005006,GO:0005178,GO:0005515,GO:0005516,GO:0005524,GO:0005615,GO:0005634,GO:0005737,GO:0005768,GO:0005789,GO:0005886,GO:0005887,GO:0005925,GO:0006357,GO:0006412,GO:0006970,GO:0007165,GO:0007166,GO:0007169,GO:0007173,GO:0007202,GO:0007275,GO:0007494,GO:0007611,GO:0007623,GO:0008284,GO:0009925,GO:0009986,GO:0010008,GO:0010750,GO:0010960,GO:0014066,GO:0016020,GO:0016101,GO:0016323,GO:0016324,GO:0018108,GO:0019899,GO:0019900,GO:0019901,GO:0019903,GO:0030054,GO:0030139,GO:0030154,GO:0030235,GO:0030307,GO:0030324,GO:0030335,GO:0030665,GO:0031625,GO:0031901,GO:0031965,GO:0032930,GO:0032991,GO:0033138,GO:0033590,GO:0033594,GO:0033674,GO:0034614,GO:0035690,GO:0038083,GO:0038128,GO:0042059,GO:0042060,GO:0042177,GO:0042327,GO:0042698,GO:0042743,GO:0042802,GO:0043006,GO:0043066,GO:0043235,GO:0043406,GO:0043586,GO:0045121,GO:0045202,GO:0045296,GO:0045737,GO:0045739,GO:0045740,GO:0045746,GO:0045780,GO:0045893,GO:0045907,GO:0045930,GO:0045944,GO:0046328,GO:0046718,GO:0046777,GO:0048143,GO:0048408,GO:0048471,GO:0048661,GO:0048812,GO:0050679,GO:0050729,GO:0050730,GO:0050999,GO:0051015,GO:0051117,GO:0051205,GO:0051592,GO:0051897,GO:0051968,GO:0061024,GO:0070141,GO:0070372,GO:0070374,GO:0070435,GO:0071260,GO:0071276,GO:0071364,GO:0071392,GO:0071549,GO:0090263,GO:0097421,GO:0097489,GO:0098609,GO:1900020,GO:1900087,GO:1901185,GO:1901224,GO:1902722,GO:1903078,GO:1903800,GO:1905208,GO:2000145" "Golgi membrane|MAPK cascade|activation of MAPKK activity|ossification|virus receptor activity|positive regulation of protein phosphorylation|hair follicle development|chromatin binding|double-stranded DNA binding|MAP kinase kinase kinase activity|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|transmembrane signaling receptor activity|epidermal growth factor-activated receptor activity|integrin binding|protein binding|calmodulin binding|ATP binding|extracellular space|nucleus|cytoplasm|endosome|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|focal adhesion|regulation of transcription by RNA polymerase II|translation|response to osmotic stress|signal transduction|cell surface receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|epidermal growth factor receptor signaling pathway|activation of phospholipase C activity|multicellular organism development|midgut development|learning or memory|circadian rhythm|positive regulation of cell population proliferation|basal plasma membrane|cell surface|endosome membrane|positive regulation of nitric oxide mediated signal transduction|magnesium ion homeostasis|regulation of phosphatidylinositol 3-kinase signaling|membrane|diterpenoid metabolic process|basolateral plasma membrane|apical plasma membrane|peptidyl-tyrosine phosphorylation|enzyme binding|kinase binding|protein kinase binding|protein phosphatase binding|cell junction|endocytic vesicle|cell differentiation|nitric-oxide synthase regulator activity|positive regulation of cell growth|lung development|positive regulation of cell migration|clathrin-coated vesicle membrane|ubiquitin protein ligase binding|early endosome membrane|nuclear membrane|positive regulation of superoxide anion generation|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|response to cobalamin|response to hydroxyisoflavone|positive regulation of kinase activity|cellular response to reactive oxygen species|cellular response to drug|peptidyl-tyrosine autophosphorylation|ERBB2 signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|wound healing|negative regulation of protein catabolic process|positive regulation of phosphorylation|ovulation cycle|hydrogen peroxide metabolic process|identical protein binding|activation of phospholipase A2 activity by calcium-mediated signaling|negative regulation of apoptotic process|receptor complex|positive regulation of MAP kinase activity|tongue development|membrane raft|synapse|cadherin binding|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of DNA repair|positive regulation of DNA replication|negative regulation of Notch signaling pathway|positive regulation of bone resorption|positive regulation of transcription, DNA-templated|positive regulation of vasoconstriction|negative regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|regulation of JNK cascade|viral entry into host cell|protein autophosphorylation|astrocyte activation|epidermal growth factor binding|perinuclear region of cytoplasm|positive regulation of smooth muscle cell proliferation|neuron projection morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of inflammatory response|regulation of peptidyl-tyrosine phosphorylation|regulation of nitric-oxide synthase activity|actin filament binding|ATPase binding|protein insertion into membrane|response to calcium ion|positive regulation of protein kinase B signaling|positive regulation of synaptic transmission, glutamatergic|membrane organization|response to UV-A|regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|Shc-EGFR complex|cellular response to mechanical stimulus|cellular response to cadmium ion|cellular response to epidermal growth factor stimulus|cellular response to estradiol stimulus|cellular response to dexamethasone stimulus|positive regulation of canonical Wnt signaling pathway|liver regeneration|multivesicular body, internal vesicle lumen|cell-cell adhesion|positive regulation of protein kinase C activity|positive regulation of G1/S transition of mitotic cell cycle|negative regulation of ERBB signaling pathway|positive regulation of NIK/NF-kappaB signaling|positive regulation of prolactin secretion|positive regulation of protein localization to plasma membrane|positive regulation of production of miRNAs involved in gene silencing by miRNA|negative regulation of cardiocyte differentiation|regulation of cell motility" "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04020,hsa04066,hsa04068,hsa04072,hsa04144,hsa04151,hsa04510,hsa04520,hsa04540,hsa04630,hsa04810,hsa04912,hsa04915,hsa04921,hsa04926,hsa04928,hsa04934,hsa05120,hsa05131,hsa05160,hsa05163,hsa05165,hsa05171,hsa05200,hsa05205,hsa05206,hsa05210,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05219,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|Endocytosis|PI3K-Akt signaling pathway|Focal adhesion|Adherens junction|Gap junction|JAK-STAT signaling pathway|Regulation of actin cytoskeleton|GnRH signaling pathway|Estrogen signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Hepatitis C|Human cytomegalovirus infection|Human papillomavirus infection|Coronavirus disease - COVID-19|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" EGLN1 1390.982212 1418.084122 1363.880302 0.961776724 -0.056226083 0.817049496 1 17.27077665 16.33267457 54583 egl-9 family hypoxia inducible factor 1 "GO:0001666,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0008198,GO:0016706,GO:0018401,GO:0019899,GO:0031418,GO:0031543,GO:0031545,GO:0032364,GO:0043433,GO:0045765,GO:0051344,GO:0055114,GO:0061418,GO:0071456,GO:0071731" response to hypoxia|protein binding|nucleus|cytoplasm|cytosol|ferrous iron binding|2-oxoglutarate-dependent dioxygenase activity|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|enzyme binding|L-ascorbic acid binding|peptidyl-proline dioxygenase activity|peptidyl-proline 4-dioxygenase activity|oxygen homeostasis|negative regulation of DNA-binding transcription factor activity|regulation of angiogenesis|negative regulation of cyclic-nucleotide phosphodiesterase activity|oxidation-reduction process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to hypoxia|response to nitric oxide "hsa04066,hsa05200,hsa05211" HIF-1 signaling pathway|Pathways in cancer|Renal cell carcinoma EGLN2 968.4282933 935.3320805 1001.524506 1.070768903 0.098647147 0.69191287 1 22.51554085 23.70551051 112398 egl-9 family hypoxia inducible factor 2 "GO:0001558,GO:0001666,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008198,GO:0016706,GO:0018401,GO:0019826,GO:0030520,GO:0031418,GO:0031543,GO:0031545,GO:0043523,GO:0045454,GO:0045732,GO:0055114,GO:0061418,GO:0071456" regulation of cell growth|response to hypoxia|protein binding|nucleus|nucleoplasm|cytoplasm|ferrous iron binding|2-oxoglutarate-dependent dioxygenase activity|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|oxygen sensor activity|intracellular estrogen receptor signaling pathway|L-ascorbic acid binding|peptidyl-proline dioxygenase activity|peptidyl-proline 4-dioxygenase activity|regulation of neuron apoptotic process|cell redox homeostasis|positive regulation of protein catabolic process|oxidation-reduction process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to hypoxia "hsa04066,hsa05200,hsa05211" HIF-1 signaling pathway|Pathways in cancer|Renal cell carcinoma other EGLN3 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.020519208 0.074555465 112399 egl-9 family hypoxia inducible factor 3 "GO:0001666,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0006919,GO:0006974,GO:0008198,GO:0016706,GO:0018126,GO:0018401,GO:0031418,GO:0031543,GO:0031545,GO:0042127,GO:0043523,GO:0055114,GO:0061418,GO:0071456" response to hypoxia|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to DNA damage stimulus|ferrous iron binding|2-oxoglutarate-dependent dioxygenase activity|protein hydroxylation|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|L-ascorbic acid binding|peptidyl-proline dioxygenase activity|peptidyl-proline 4-dioxygenase activity|regulation of cell population proliferation|regulation of neuron apoptotic process|oxidation-reduction process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to hypoxia "hsa04066,hsa05200,hsa05211" HIF-1 signaling pathway|Pathways in cancer|Renal cell carcinoma EGR1 939.2589188 573.2680493 1305.249788 2.276857728 1.187044146 2.14E-06 0.001275045 9.752713475 21.83396139 1958 early growth response 1 "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001666,GO:0002931,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0008270,GO:0009749,GO:0010385,GO:0010628,GO:0030217,GO:0030509,GO:0032722,GO:0032731,GO:0032868,GO:0032922,GO:0033233,GO:0035035,GO:0035914,GO:0042981,GO:0043565,GO:0044729,GO:0044849,GO:0045475,GO:0045893,GO:0045944,GO:0046886,GO:0060086,GO:0060337,GO:0061418,GO:0070498,GO:0071480,GO:0071504,GO:0071506,GO:0072110,GO:0072303,GO:0090090,GO:0098759,GO:1901216,GO:1902895,GO:1902949,GO:1990837,GO:1990841,GO:2000182" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|response to hypoxia|response to ischemia|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|zinc ion binding|response to glucose|double-stranded methylated DNA binding|positive regulation of gene expression|T cell differentiation|BMP signaling pathway|positive regulation of chemokine production|positive regulation of interleukin-1 beta production|response to insulin|circadian regulation of gene expression|regulation of protein sumoylation|histone acetyltransferase binding|skeletal muscle cell differentiation|regulation of apoptotic process|sequence-specific DNA binding|hemi-methylated DNA-binding|estrous cycle|locomotor rhythm|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of hormone biosynthetic process|circadian temperature homeostasis|type I interferon signaling pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|cellular response to gamma radiation|cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|positive regulation of glomerular metanephric mesangial cell proliferation|negative regulation of canonical Wnt signaling pathway|cellular response to interleukin-8|positive regulation of neuron death|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of tau-protein kinase activity|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding|regulation of progesterone biosynthetic process" "hsa04371,hsa04912,hsa04928,hsa04933,hsa05020,hsa05166" "Apelin signaling pathway|GnRH signaling pathway|Parathyroid hormone synthesis, secretion and action|AGE-RAGE signaling pathway in diabetic complications|Prion disease|Human T-cell leukemia virus 1 infection" zf-C2H2 EGR2 15.69049658 20.80827765 10.57271552 0.508101424 -0.976811586 0.309335093 1 0.351980835 0.175849286 1959 early growth response 2 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001102,GO:0001228,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006611,GO:0007420,GO:0007422,GO:0007611,GO:0007622,GO:0008045,GO:0010467,GO:0014037,GO:0014040,GO:0016925,GO:0021612,GO:0021659,GO:0021660,GO:0021665,GO:0021666,GO:0030278,GO:0031625,GO:0031643,GO:0032868,GO:0035284,GO:0035914,GO:0042552,GO:0043231,GO:0043565,GO:0045444,GO:0045893,GO:0045944,GO:0046872,GO:0048168,GO:0061665,GO:0071310,GO:0071837,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II activating transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|protein export from nucleus|brain development|peripheral nervous system development|learning or memory|rhythmic behavior|motor neuron axon guidance|gene expression|Schwann cell differentiation|positive regulation of Schwann cell differentiation|protein sumoylation|facial nerve structural organization|rhombomere 3 structural organization|rhombomere 3 formation|rhombomere 5 structural organization|rhombomere 5 formation|regulation of ossification|ubiquitin protein ligase binding|positive regulation of myelination|response to insulin|brain segmentation|skeletal muscle cell differentiation|myelination|intracellular membrane-bounded organelle|sequence-specific DNA binding|fat cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|regulation of neuronal synaptic plasticity|SUMO ligase activity|cellular response to organic substance|HMG box domain binding|sequence-specific double-stranded DNA binding" "hsa04625,hsa05161,hsa05166,hsa05203" C-type lectin receptor signaling pathway|Hepatitis B|Human T-cell leukemia virus 1 infection|Viral carcinogenesis zf-C2H2 EGR3 9.368755362 6.242483296 12.49502743 2.001611672 1.001162108 0.427900976 1 0.072141589 0.141983118 1960 early growth response 3 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001938,GO:0002042,GO:0003700,GO:0005634,GO:0006357,GO:0007274,GO:0007422,GO:0007517,GO:0007623,GO:0033089,GO:0035767,GO:0035924,GO:0043066,GO:0044344,GO:0045202,GO:0045586,GO:0045944,GO:0046872,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|positive regulation of endothelial cell proliferation|cell migration involved in sprouting angiogenesis|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|neuromuscular synaptic transmission|peripheral nervous system development|muscle organ development|circadian rhythm|positive regulation of T cell differentiation in thymus|endothelial cell chemotaxis|cellular response to vascular endothelial growth factor stimulus|negative regulation of apoptotic process|cellular response to fibroblast growth factor stimulus|synapse|regulation of gamma-delta T cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" "hsa04625,hsa05161,hsa05203" C-type lectin receptor signaling pathway|Hepatitis B|Viral carcinogenesis zf-C2H2 EGR4 6.604174384 9.363724944 3.844623824 0.41058701 -1.284240111 0.3924594 1 0.225101257 0.090877067 1961 early growth response 4 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0008284,GO:0043565,GO:0045944,GO:0046872,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of cell population proliferation|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" EHBP1 1534.422777 1348.376392 1720.469161 1.275956159 0.351578759 0.140335702 1 9.529912571 11.95627368 23301 EH domain binding protein 1 "GO:0005654,GO:0005768,GO:0005815,GO:0005829,GO:0005886,GO:0006897,GO:0015031,GO:0030036,GO:0031941" nucleoplasm|endosome|microtubule organizing center|cytosol|plasma membrane|endocytosis|protein transport|actin cytoskeleton organization|filamentous actin EHBP1L1 3379.409097 3317.879872 3440.938322 1.037089483 0.05254038 0.825722276 1 32.76024991 33.40677984 254102 EH domain binding protein 1 like 1 "GO:0003674,GO:0005768,GO:0005815,GO:0008150,GO:0016020,GO:0030036,GO:0031941" molecular_function|endosome|microtubule organizing center|biological_process|membrane|actin cytoskeleton organization|filamentous actin EHD1 3634.014817 3567.579204 3700.450431 1.037244086 0.052755432 0.825201896 1 39.20015342 39.97973514 10938 EH domain containing 1 "GO:0005509,GO:0005515,GO:0005524,GO:0005525,GO:0005737,GO:0005769,GO:0005811,GO:0005886,GO:0006886,GO:0006897,GO:0007596,GO:0010008,GO:0010886,GO:0016020,GO:0016197,GO:0020018,GO:0030139,GO:0031095,GO:0031175,GO:0031267,GO:0031901,GO:0032456,GO:0034383,GO:0042632,GO:0042802,GO:0043231,GO:0045296,GO:0048471,GO:0051260,GO:0055038,GO:0060271,GO:0061512,GO:0070062,GO:0072659,GO:1901741,GO:1990090,GO:2001137" calcium ion binding|protein binding|ATP binding|GTP binding|cytoplasm|early endosome|lipid droplet|plasma membrane|intracellular protein transport|endocytosis|blood coagulation|endosome membrane|positive regulation of cholesterol storage|membrane|endosomal transport|ciliary pocket membrane|endocytic vesicle|platelet dense tubular network membrane|neuron projection development|small GTPase binding|early endosome membrane|endocytic recycling|low-density lipoprotein particle clearance|cholesterol homeostasis|identical protein binding|intracellular membrane-bounded organelle|cadherin binding|perinuclear region of cytoplasm|protein homooligomerization|recycling endosome membrane|cilium assembly|protein localization to cilium|extracellular exosome|protein localization to plasma membrane|positive regulation of myoblast fusion|cellular response to nerve growth factor stimulus|positive regulation of endocytic recycling hsa04144 Endocytosis EHD2 2241.67516 2139.090943 2344.259377 1.095913844 0.132134384 0.576978827 1 32.56113866 35.08707581 30846 EH domain containing 2 "GO:0003676,GO:0005509,GO:0005515,GO:0005524,GO:0005525,GO:0005634,GO:0005737,GO:0005769,GO:0005829,GO:0005886,GO:0005901,GO:0006897,GO:0007596,GO:0010008,GO:0015630,GO:0016197,GO:0016787,GO:0019898,GO:0019904,GO:0030139,GO:0030866,GO:0032456,GO:0042802,GO:0043231,GO:0045171,GO:0048471,GO:0055038,GO:0060271,GO:0070062,GO:0072659,GO:0097320,GO:1901741,GO:2001137" nucleic acid binding|calcium ion binding|protein binding|ATP binding|GTP binding|nucleus|cytoplasm|early endosome|cytosol|plasma membrane|caveola|endocytosis|blood coagulation|endosome membrane|microtubule cytoskeleton|endosomal transport|hydrolase activity|extrinsic component of membrane|protein domain specific binding|endocytic vesicle|cortical actin cytoskeleton organization|endocytic recycling|identical protein binding|intracellular membrane-bounded organelle|intercellular bridge|perinuclear region of cytoplasm|recycling endosome membrane|cilium assembly|extracellular exosome|protein localization to plasma membrane|plasma membrane tubulation|positive regulation of myoblast fusion|positive regulation of endocytic recycling hsa04144 Endocytosis EHD3 361.0009227 380.791481 341.2103644 0.896055667 -0.158339734 0.599788031 1 4.148222388 3.654838577 30845 EH domain containing 3 "GO:0001881,GO:0003676,GO:0005509,GO:0005515,GO:0005524,GO:0005525,GO:0005634,GO:0005737,GO:0005769,GO:0005829,GO:0005886,GO:0005925,GO:0006897,GO:0007596,GO:0010008,GO:0015031,GO:0016197,GO:0020018,GO:0030139,GO:0032456,GO:0034498,GO:0043231,GO:0048471,GO:0051260,GO:0055038,GO:0055117,GO:0060271,GO:0072659,GO:0086036,GO:0090160,GO:1901387,GO:1903358,GO:1903779" receptor recycling|nucleic acid binding|calcium ion binding|protein binding|ATP binding|GTP binding|nucleus|cytoplasm|early endosome|cytosol|plasma membrane|focal adhesion|endocytosis|blood coagulation|endosome membrane|protein transport|endosomal transport|ciliary pocket membrane|endocytic vesicle|endocytic recycling|early endosome to Golgi transport|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|protein homooligomerization|recycling endosome membrane|regulation of cardiac muscle contraction|cilium assembly|protein localization to plasma membrane|regulation of cardiac muscle cell membrane potential|Golgi to lysosome transport|positive regulation of voltage-gated calcium channel activity|regulation of Golgi organization|regulation of cardiac conduction hsa04144 Endocytosis EHD4 2012.450754 1912.280716 2112.620791 1.104764993 0.14373951 0.544307947 1 15.94358807 17.31917289 30844 EH domain containing 4 "GO:0003676,GO:0005509,GO:0005515,GO:0005524,GO:0005525,GO:0005634,GO:0005737,GO:0005769,GO:0005783,GO:0005886,GO:0006897,GO:0006907,GO:0016020,GO:0016197,GO:0030100,GO:0030139,GO:0031901,GO:0032456,GO:0043231,GO:0045296,GO:0048471,GO:0050731,GO:0051260,GO:0055038,GO:0060271,GO:0070062,GO:0071363,GO:0072659" nucleic acid binding|calcium ion binding|protein binding|ATP binding|GTP binding|nucleus|cytoplasm|early endosome|endoplasmic reticulum|plasma membrane|endocytosis|pinocytosis|membrane|endosomal transport|regulation of endocytosis|endocytic vesicle|early endosome membrane|endocytic recycling|intracellular membrane-bounded organelle|cadherin binding|perinuclear region of cytoplasm|positive regulation of peptidyl-tyrosine phosphorylation|protein homooligomerization|recycling endosome membrane|cilium assembly|extracellular exosome|cellular response to growth factor stimulus|protein localization to plasma membrane hsa04144 Endocytosis EHF 441.4682236 752.2192372 130.71721 0.173775415 -2.524704106 6.31E-17 4.62E-13 5.565584107 0.950977546 26298 ETS homologous factor "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005794,GO:0006357,GO:0006366,GO:0007275,GO:0030154,GO:0030855,GO:0045893,GO:0045944,GO:0050673" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleus|nucleoplasm|Golgi apparatus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|multicellular organism development|cell differentiation|epithelial cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|epithelial cell proliferation" ETS EHHADH 392.8329257 396.3976893 389.2681622 0.982014206 -0.0261842 0.937553966 1 5.348929489 5.164827511 1962 enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase "GO:0003857,GO:0004165,GO:0004300,GO:0005515,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0006635,GO:0016508,GO:0016509,GO:0016863,GO:0019899,GO:0033540" "3-hydroxyacyl-CoA dehydrogenase activity|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity|protein binding|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid beta-oxidation|long-chain-enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|intramolecular oxidoreductase activity, transposing C=C bonds|enzyme binding|fatty acid beta-oxidation using acyl-CoA oxidase" "hsa00071,hsa00280,hsa00310,hsa00380,hsa00410,hsa00640,hsa00650,hsa03320,hsa04146" "Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|beta-Alanine metabolism|Propanoate metabolism|Butanoate metabolism|PPAR signaling pathway|Peroxisome" EHMT1 1271.532146 1284.911145 1258.153146 0.979175215 -0.030361054 0.903040244 1 6.664076409 6.416106416 79813 euchromatic histone lysine methyltransferase 1 "GO:0000122,GO:0001226,GO:0002039,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006306,GO:0006325,GO:0008168,GO:0008270,GO:0016279,GO:0016571,GO:0016604,GO:0018024,GO:0018026,GO:0018027,GO:0045892,GO:0045995,GO:0046974,GO:0046976,GO:0051567,GO:0060992,GO:0070317,GO:0070734,GO:0070742,GO:0120162,GO:1901796" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription corepressor binding|p53 binding|protein binding|nucleus|nucleoplasm|chromosome|DNA methylation|chromatin organization|methyltransferase activity|zinc ion binding|protein-lysine N-methyltransferase activity|histone methylation|nuclear body|histone-lysine N-methyltransferase activity|peptidyl-lysine monomethylation|peptidyl-lysine dimethylation|negative regulation of transcription, DNA-templated|regulation of embryonic development|histone methyltransferase activity (H3-K9 specific)|histone methyltransferase activity (H3-K27 specific)|histone H3-K9 methylation|response to fungicide|negative regulation of G0 to G1 transition|histone H3-K27 methylation|C2H2 zinc finger domain binding|positive regulation of cold-induced thermogenesis|regulation of signal transduction by p53 class mediator" "hsa00310,hsa04211" Lysine degradation|Longevity regulating pathway EHMT2 927.6433319 974.867808 880.4188557 0.903116144 -0.147016559 0.554540452 1 12.11900843 10.76172455 10919 euchromatic histone lysine methyltransferase 2 "GO:0000122,GO:0000785,GO:0001226,GO:0002039,GO:0005515,GO:0005634,GO:0005654,GO:0006275,GO:0006306,GO:0008270,GO:0009267,GO:0016279,GO:0016571,GO:0016607,GO:0018024,GO:0018027,GO:0034968,GO:0046974,GO:0046976,GO:0051567,GO:0070317,GO:0070734,GO:0070742,GO:1901796,GO:1990841" negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription corepressor binding|p53 binding|protein binding|nucleus|nucleoplasm|regulation of DNA replication|DNA methylation|zinc ion binding|cellular response to starvation|protein-lysine N-methyltransferase activity|histone methylation|nuclear speck|histone-lysine N-methyltransferase activity|peptidyl-lysine dimethylation|histone lysine methylation|histone methyltransferase activity (H3-K9 specific)|histone methyltransferase activity (H3-K27 specific)|histone H3-K9 methylation|negative regulation of G0 to G1 transition|histone H3-K27 methylation|C2H2 zinc finger domain binding|regulation of signal transduction by p53 class mediator|promoter-specific chromatin binding "hsa00310,hsa04211" Lysine degradation|Longevity regulating pathway other EI24 2071.843049 2108.91894 2034.767159 0.964838961 -0.051639929 0.828920753 1 44.32813226 42.05381926 9538 EI24 autophagy associated transmembrane protein "GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006915,GO:0016020,GO:0016021,GO:0016236,GO:0030308,GO:0031965,GO:0061676" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|apoptotic process|membrane|integral component of membrane|macroautophagy|negative regulation of cell growth|nuclear membrane|importin-alpha family protein binding hsa04115 p53 signaling pathway EID1 3066.507444 2635.368365 3497.646524 1.327194547 0.408379864 0.084796229 1 68.94351276 89.97030129 23741 EP300 interacting inhibitor of differentiation 1 "GO:0000122,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0007049,GO:0030154,GO:0035034,GO:0035035,GO:0035065,GO:0036464,GO:0045595,GO:0045892" "negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cell cycle|cell differentiation|histone acetyltransferase regulator activity|histone acetyltransferase binding|regulation of histone acetylation|cytoplasmic ribonucleoprotein granule|regulation of cell differentiation|negative regulation of transcription, DNA-templated" EID2 266.3081681 228.8910542 303.7252821 1.326942563 0.408105925 0.214108759 1 8.395529126 10.95396568 163126 EP300 interacting inhibitor of differentiation 2 "GO:0000122,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0007181,GO:0007183,GO:0007517,GO:0017015,GO:0030154,GO:0030512,GO:0042127,GO:0045892,GO:0046332" "negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transforming growth factor beta receptor complex assembly|SMAD protein complex assembly|muscle organ development|regulation of transforming growth factor beta receptor signaling pathway|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of cell population proliferation|negative regulation of transcription, DNA-templated|SMAD binding" EID2B 57.04977082 46.81862472 67.28091692 1.437054534 0.523114811 0.366827968 1 1.33902677 1.892054697 126272 EP300 interacting inhibitor of differentiation 2B "GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0007517,GO:0030154,GO:0042802,GO:0045662,GO:0045892" "transcription corepressor activity|protein binding|nucleus|nucleoplasm|muscle organ development|cell differentiation|identical protein binding|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-templated" EID3 18.81676865 14.56579436 23.06774294 1.583692752 0.663292469 0.469275015 1 0.529890712 0.82514147 493861 EP300 interacting inhibitor of differentiation 3 "GO:0000781,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006281,GO:0006310,GO:0030915" "chromosome, telomeric region|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|DNA repair|DNA recombination|Smc5-Smc6 complex" EIF1 10186.84051 9867.285263 10506.39575 1.064770651 0.090542711 0.719266369 1 225.2347644 235.8102475 10209 eukaryotic translation initiation factor 1 "GO:0003723,GO:0003743,GO:0005515,GO:0005634,GO:0005737,GO:0006413,GO:0006446,GO:0008135,GO:0016282,GO:0043024" "RNA binding|translation initiation factor activity|protein binding|nucleus|cytoplasm|translational initiation|regulation of translational initiation|translation factor activity, RNA binding|eukaryotic 43S preinitiation complex|ribosomal small subunit binding" hsa03013 RNA transport EIF1AD 570.9034443 554.5405994 587.2662891 1.059014055 0.082721737 0.760717387 1 9.680998557 10.08075496 84285 eukaryotic translation initiation factor 1A domain containing "GO:0003743,GO:0005515,GO:0005654,GO:0006413,GO:0043231,GO:0045111" translation initiation factor activity|protein binding|nucleoplasm|translational initiation|intracellular membrane-bounded organelle|intermediate filament cytoskeleton EIF1AX 2808.031334 2549.014012 3067.048656 1.203229421 0.266911749 0.259282408 1 30.81925531 36.46210707 1964 eukaryotic translation initiation factor 1A X-linked "GO:0003723,GO:0003743,GO:0005515,GO:0005829,GO:0006413,GO:0008135" "RNA binding|translation initiation factor activity|protein binding|cytosol|translational initiation|translation factor activity, RNA binding" hsa03013 RNA transport EIF1B 1065.817046 956.1403581 1175.493734 1.229415456 0.297972527 0.223069792 1 51.69954772 62.49662877 10289 eukaryotic translation initiation factor 1B "GO:0003723,GO:0003743,GO:0005515,GO:0005575,GO:0006413,GO:0006446,GO:0016282,GO:0043024" RNA binding|translation initiation factor activity|protein binding|cellular_component|translational initiation|regulation of translational initiation|eukaryotic 43S preinitiation complex|ribosomal small subunit binding hsa03013 RNA transport EIF2A 2727.94719 2717.561061 2738.333319 1.007643713 0.010985615 0.964650778 1 48.16713357 47.72313665 83939 eukaryotic translation initiation factor 2A "GO:0000049,GO:0003729,GO:0003743,GO:0005515,GO:0005615,GO:0005737,GO:0005850,GO:0006413,GO:0006417,GO:0006468,GO:0009967,GO:0022627,GO:0032933,GO:0042255,GO:0043022,GO:0045296,GO:0072562,GO:1990928" tRNA binding|mRNA binding|translation initiation factor activity|protein binding|extracellular space|cytoplasm|eukaryotic translation initiation factor 2 complex|translational initiation|regulation of translation|protein phosphorylation|positive regulation of signal transduction|cytosolic small ribosomal subunit|SREBP signaling pathway|ribosome assembly|ribosome binding|cadherin binding|blood microparticle|response to amino acid starvation EIF2AK1 4764.20416 4586.144395 4942.263926 1.077651182 0.107890276 0.652856101 1 53.40477796 56.58867194 27102 eukaryotic translation initiation factor 2 alpha kinase 1 "GO:0002526,GO:0004672,GO:0004694,GO:0005515,GO:0005524,GO:0005737,GO:0006909,GO:0008285,GO:0010998,GO:0010999,GO:0020037,GO:0030225,GO:0042803,GO:0045993,GO:0046501,GO:0046777,GO:0046986,GO:0055072,GO:0106310,GO:0106311,GO:0140467,GO:0140468,GO:1990641" acute inflammatory response|protein kinase activity|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|ATP binding|cytoplasm|phagocytosis|negative regulation of cell population proliferation|regulation of translational initiation by eIF2 alpha phosphorylation|regulation of eIF2 alpha phosphorylation by heme|heme binding|macrophage differentiation|protein homodimerization activity|negative regulation of translational initiation by iron|protoporphyrinogen IX metabolic process|protein autophosphorylation|negative regulation of hemoglobin biosynthetic process|iron ion homeostasis|protein serine kinase activity|protein threonine kinase activity|integrated stress response signaling|HRI-mediated signaling|response to iron ion starvation "hsa04141,hsa05160,hsa05162,hsa05168" Protein processing in endoplasmic reticulum|Hepatitis C|Measles|Herpes simplex virus 1 infection EIF2AK2 2699.612597 2768.541342 2630.683852 0.950205732 -0.073688186 0.756445496 1 14.81668302 13.84330585 5610 eukaryotic translation initiation factor 2 alpha kinase 2 "GO:0000186,GO:0001819,GO:0003723,GO:0003725,GO:0004672,GO:0004674,GO:0004694,GO:0004715,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005840,GO:0006468,GO:0008285,GO:0009615,GO:0010998,GO:0016020,GO:0017148,GO:0018108,GO:0019888,GO:0030683,GO:0032722,GO:0032874,GO:0033689,GO:0034198,GO:0035455,GO:0042802,GO:0043666,GO:0045071,GO:0045087,GO:0046777,GO:0048471,GO:0051092,GO:0051607,GO:0106310,GO:0106311,GO:1900225,GO:1901224,GO:1901532,GO:1902033,GO:1902036" activation of MAPKK activity|positive regulation of cytokine production|RNA binding|double-stranded RNA binding|protein kinase activity|protein serine/threonine kinase activity|eukaryotic translation initiation factor 2alpha kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|ribosome|protein phosphorylation|negative regulation of cell population proliferation|response to virus|regulation of translational initiation by eIF2 alpha phosphorylation|membrane|negative regulation of translation|peptidyl-tyrosine phosphorylation|protein phosphatase regulator activity|mitigation of host immune response by virus|positive regulation of chemokine production|positive regulation of stress-activated MAPK cascade|negative regulation of osteoblast proliferation|cellular response to amino acid starvation|response to interferon-alpha|identical protein binding|regulation of phosphoprotein phosphatase activity|negative regulation of viral genome replication|innate immune response|protein autophosphorylation|perinuclear region of cytoplasm|positive regulation of NF-kappaB transcription factor activity|defense response to virus|protein serine kinase activity|protein threonine kinase activity|regulation of NLRP3 inflammasome complex assembly|positive regulation of NIK/NF-kappaB signaling|regulation of hematopoietic progenitor cell differentiation|regulation of hematopoietic stem cell proliferation|regulation of hematopoietic stem cell differentiation "hsa04141,hsa04217,hsa05010,hsa05160,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05171,hsa05203" Protein processing in endoplasmic reticulum|Necroptosis|Alzheimer disease|Hepatitis C|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Viral carcinogenesis EIF2AK3 481.4020839 538.9343912 423.8697766 0.786496062 -0.346488552 0.209060112 1 6.088471198 4.70842858 9451 eukaryotic translation initiation factor 2 alpha kinase 3 "GO:0001501,GO:0001503,GO:0001525,GO:0002063,GO:0004672,GO:0004674,GO:0004694,GO:0005515,GO:0005524,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0006468,GO:0006919,GO:0006983,GO:0007029,GO:0010575,GO:0010628,GO:0010998,GO:0016020,GO:0017148,GO:0018105,GO:0019722,GO:0019899,GO:0019903,GO:0030176,GO:0030282,GO:0030968,GO:0031018,GO:0031642,GO:0032057,GO:0034198,GO:0034976,GO:0036492,GO:0036499,GO:0042149,GO:0042802,GO:0045943,GO:0046777,GO:0048009,GO:0048471,GO:0051879,GO:0060734,GO:0070417,GO:0106310,GO:0106311,GO:1900182,GO:1902235,GO:1990737" skeletal system development|ossification|angiogenesis|chondrocyte development|protein kinase activity|protein serine/threonine kinase activity|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|ATP binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|protein phosphorylation|activation of cysteine-type endopeptidase activity involved in apoptotic process|ER overload response|endoplasmic reticulum organization|positive regulation of vascular endothelial growth factor production|positive regulation of gene expression|regulation of translational initiation by eIF2 alpha phosphorylation|membrane|negative regulation of translation|peptidyl-serine phosphorylation|calcium-mediated signaling|enzyme binding|protein phosphatase binding|integral component of endoplasmic reticulum membrane|bone mineralization|endoplasmic reticulum unfolded protein response|endocrine pancreas development|negative regulation of myelination|negative regulation of translational initiation in response to stress|cellular response to amino acid starvation|response to endoplasmic reticulum stress|eiF2alpha phosphorylation in response to endoplasmic reticulum stress|PERK-mediated unfolded protein response|cellular response to glucose starvation|identical protein binding|positive regulation of transcription by RNA polymerase I|protein autophosphorylation|insulin-like growth factor receptor signaling pathway|perinuclear region of cytoplasm|Hsp90 protein binding|regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation|cellular response to cold|protein serine kinase activity|protein threonine kinase activity|positive regulation of protein localization to nucleus|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|response to manganese-induced endoplasmic reticulum stress "hsa04137,hsa04140,hsa04141,hsa04210,hsa04932,hsa05010,hsa05012,hsa05014,hsa05020,hsa05022,hsa05160,hsa05162,hsa05168" Mitophagy - animal|Autophagy - animal|Protein processing in endoplasmic reticulum|Apoptosis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Hepatitis C|Measles|Herpes simplex virus 1 infection EIF2AK4 2825.414586 2841.370313 2809.458859 0.988768992 -0.016294595 0.94666696 1 27.38149357 26.62092553 440275 eukaryotic translation initiation factor 2 alpha kinase 4 "GO:0000049,GO:0000077,GO:0002230,GO:0002250,GO:0002286,GO:0002821,GO:0004672,GO:0004674,GO:0004694,GO:0005524,GO:0005829,GO:0005844,GO:0006446,GO:0006468,GO:0007050,GO:0007612,GO:0007616,GO:0010998,GO:0019081,GO:0022626,GO:0032057,GO:0032792,GO:0034198,GO:0034644,GO:0036492,GO:0039520,GO:0044828,GO:0045665,GO:0045947,GO:0046777,GO:0051607,GO:0060259,GO:0070417,GO:0071264,GO:0106310,GO:0106311,GO:0140469,GO:1900273,GO:1990138,GO:1990253" tRNA binding|DNA damage checkpoint|positive regulation of defense response to virus by host|adaptive immune response|T cell activation involved in immune response|positive regulation of adaptive immune response|protein kinase activity|protein serine/threonine kinase activity|eukaryotic translation initiation factor 2alpha kinase activity|ATP binding|cytosol|polysome|regulation of translational initiation|protein phosphorylation|cell cycle arrest|learning|long-term memory|regulation of translational initiation by eIF2 alpha phosphorylation|viral translation|cytosolic ribosome|negative regulation of translational initiation in response to stress|negative regulation of CREB transcription factor activity|cellular response to amino acid starvation|cellular response to UV|eiF2alpha phosphorylation in response to endoplasmic reticulum stress|induction by virus of host autophagy|negative regulation by host of viral genome replication|negative regulation of neuron differentiation|negative regulation of translational initiation|protein autophosphorylation|defense response to virus|regulation of feeding behavior|cellular response to cold|positive regulation of translational initiation in response to starvation|protein serine kinase activity|protein threonine kinase activity|GCN2-mediated signaling|positive regulation of long-term synaptic potentiation|neuron projection extension|cellular response to leucine starvation "hsa04140,hsa04141,hsa05160,hsa05162,hsa05168" Autophagy - animal|Protein processing in endoplasmic reticulum|Hepatitis C|Measles|Herpes simplex virus 1 infection EIF2B1 975.641379 1023.767261 927.5154975 0.905982769 -0.142444483 0.565048949 1 22.79373262 20.30516701 1967 eukaryotic translation initiation factor 2B subunit alpha "GO:0003743,GO:0005085,GO:0005515,GO:0005737,GO:0005829,GO:0005851,GO:0005886,GO:0006413,GO:0006446,GO:0009408,GO:0009749,GO:0014003,GO:0016020,GO:0042802,GO:0043434,GO:0050790,GO:0050852" translation initiation factor activity|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|cytosol|eukaryotic translation initiation factor 2B complex|plasma membrane|translational initiation|regulation of translational initiation|response to heat|response to glucose|oligodendrocyte development|membrane|identical protein binding|response to peptide hormone|regulation of catalytic activity|T cell receptor signaling pathway "hsa03013,hsa05168" RNA transport|Herpes simplex virus 1 infection EIF2B2 1218.744024 1097.636646 1339.851403 1.220669342 0.287672452 0.234403737 1 13.6103277 16.33570183 8892 eukaryotic translation initiation factor 2B subunit beta "GO:0001541,GO:0003743,GO:0005085,GO:0005515,GO:0005524,GO:0005525,GO:0005737,GO:0005829,GO:0005851,GO:0006413,GO:0006446,GO:0007417,GO:0009408,GO:0009749,GO:0014003,GO:0042552,GO:0043434,GO:0050790,GO:0050852" ovarian follicle development|translation initiation factor activity|guanyl-nucleotide exchange factor activity|protein binding|ATP binding|GTP binding|cytoplasm|cytosol|eukaryotic translation initiation factor 2B complex|translational initiation|regulation of translational initiation|central nervous system development|response to heat|response to glucose|oligodendrocyte development|myelination|response to peptide hormone|regulation of catalytic activity|T cell receptor signaling pathway "hsa03013,hsa05168" RNA transport|Herpes simplex virus 1 infection EIF2B3 570.8392776 515.0048719 626.6736833 1.216830592 0.283128329 0.287125425 1 11.3573816 13.58875024 8891 eukaryotic translation initiation factor 2B subunit gamma "GO:0002183,GO:0003743,GO:0005085,GO:0005515,GO:0005737,GO:0005829,GO:0005851,GO:0006413,GO:0008135,GO:0009408,GO:0009749,GO:0014003,GO:0021766,GO:0032045,GO:0043434,GO:0050790,GO:0050852" "cytoplasmic translational initiation|translation initiation factor activity|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|cytosol|eukaryotic translation initiation factor 2B complex|translational initiation|translation factor activity, RNA binding|response to heat|response to glucose|oligodendrocyte development|hippocampus development|guanyl-nucleotide exchange factor complex|response to peptide hormone|regulation of catalytic activity|T cell receptor signaling pathway" "hsa03013,hsa05168" RNA transport|Herpes simplex virus 1 infection EIF2B4 626.6152768 641.9353656 611.295188 0.952269061 -0.070558834 0.791961532 1 17.76914452 16.63785644 8890 eukaryotic translation initiation factor 2B subunit delta "GO:0001541,GO:0003743,GO:0005085,GO:0005515,GO:0005737,GO:0005829,GO:0005851,GO:0006413,GO:0006417,GO:0009408,GO:0009749,GO:0014003,GO:0031369,GO:0042552,GO:0043434,GO:0050790,GO:0050852" ovarian follicle development|translation initiation factor activity|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|cytosol|eukaryotic translation initiation factor 2B complex|translational initiation|regulation of translation|response to heat|response to glucose|oligodendrocyte development|translation initiation factor binding|myelination|response to peptide hormone|regulation of catalytic activity|T cell receptor signaling pathway "hsa03013,hsa05168" RNA transport|Herpes simplex virus 1 infection EIF2B5 884.5598905 954.0595304 815.0602507 0.85430754 -0.227172579 0.361888495 1 19.53814415 16.41227282 8893 eukaryotic translation initiation factor 2B subunit epsilon "GO:0001541,GO:0003743,GO:0005085,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005851,GO:0006413,GO:0009408,GO:0009749,GO:0014002,GO:0014003,GO:0031369,GO:0034976,GO:0042552,GO:0043434,GO:0045948,GO:0048708,GO:0050790,GO:0050852" ovarian follicle development|translation initiation factor activity|guanyl-nucleotide exchange factor activity|protein binding|nucleus|cytoplasm|cytosol|eukaryotic translation initiation factor 2B complex|translational initiation|response to heat|response to glucose|astrocyte development|oligodendrocyte development|translation initiation factor binding|response to endoplasmic reticulum stress|myelination|response to peptide hormone|positive regulation of translational initiation|astrocyte differentiation|regulation of catalytic activity|T cell receptor signaling pathway "hsa03013,hsa05168" RNA transport|Herpes simplex virus 1 infection EIF2D 1119.437376 1165.263549 1073.611203 0.921346252 -0.118184656 0.629394066 1 12.01467811 10.88444257 1939 eukaryotic translation initiation factor 2D "GO:0001731,GO:0003743,GO:0005737,GO:0005829,GO:0006886,GO:0016604,GO:0022627,GO:0032790,GO:0038023,GO:0075522" formation of translation preinitiation complex|translation initiation factor activity|cytoplasm|cytosol|intracellular protein transport|nuclear body|cytosolic small ribosomal subunit|ribosome disassembly|signaling receptor activity|IRES-dependent viral translational initiation EIF2S1 2745.903411 2482.427524 3009.379298 1.212272773 0.277714356 0.240401302 1 31.89277671 38.01577618 1965 eukaryotic translation initiation factor 2 subunit alpha "GO:0003723,GO:0003743,GO:0005515,GO:0005634,GO:0005829,GO:0005844,GO:0005850,GO:0005851,GO:0006413,GO:0007568,GO:0010494,GO:0016020,GO:0032057,GO:0033290,GO:0034063,GO:0034198,GO:0034599,GO:0034605,GO:0034644,GO:0034976,GO:0036499,GO:0043022,GO:0043614,GO:0044207,GO:0045202,GO:0046777,GO:0055085,GO:0070062,GO:0097451,GO:1901216,GO:1905098,GO:1990737,GO:2000676" RNA binding|translation initiation factor activity|protein binding|nucleus|cytosol|polysome|eukaryotic translation initiation factor 2 complex|eukaryotic translation initiation factor 2B complex|translational initiation|aging|cytoplasmic stress granule|membrane|negative regulation of translational initiation in response to stress|eukaryotic 48S preinitiation complex|stress granule assembly|cellular response to amino acid starvation|cellular response to oxidative stress|cellular response to heat|cellular response to UV|response to endoplasmic reticulum stress|PERK-mediated unfolded protein response|ribosome binding|multi-eIF complex|translation initiation ternary complex|synapse|protein autophosphorylation|transmembrane transport|extracellular exosome|glial limiting end-foot|positive regulation of neuron death|negative regulation of guanyl-nucleotide exchange factor activity|response to manganese-induced endoplasmic reticulum stress|positive regulation of type B pancreatic cell apoptotic process "hsa03013,hsa04140,hsa04141,hsa04210,hsa04932,hsa05010,hsa05012,hsa05014,hsa05020,hsa05022,hsa05160,hsa05162,hsa05164,hsa05168" RNA transport|Autophagy - animal|Protein processing in endoplasmic reticulum|Apoptosis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Hepatitis C|Measles|Influenza A|Herpes simplex virus 1 infection EIF2S2 6726.827675 6615.99188 6837.663471 1.033505421 0.047545956 0.845865494 1 118.8032729 120.7292054 8894 eukaryotic translation initiation factor 2 subunit beta "GO:0001701,GO:0001731,GO:0001732,GO:0002176,GO:0003723,GO:0003729,GO:0003743,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005850,GO:0006413,GO:0008135,GO:0008584,GO:0031369,GO:0046872,GO:0055085" "in utero embryonic development|formation of translation preinitiation complex|formation of cytoplasmic translation initiation complex|male germ cell proliferation|RNA binding|mRNA binding|translation initiation factor activity|protein binding|nucleus|cytoplasm|cytosol|eukaryotic translation initiation factor 2 complex|translational initiation|translation factor activity, RNA binding|male gonad development|translation initiation factor binding|metal ion binding|transmembrane transport" hsa03013 RNA transport EIF2S3 10312.35576 10651.75733 9972.954199 0.936273132 -0.094998637 0.706363417 1 164.4387364 151.3832658 1968 eukaryotic translation initiation factor 2 subunit gamma "GO:0000049,GO:0001731,GO:0003743,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005829,GO:0005850,GO:0006413,GO:0008135,GO:0045296,GO:0045903,GO:0055085,GO:0070062" "tRNA binding|formation of translation preinitiation complex|translation initiation factor activity|GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|cytosol|eukaryotic translation initiation factor 2 complex|translational initiation|translation factor activity, RNA binding|cadherin binding|positive regulation of translational fidelity|transmembrane transport|extracellular exosome" hsa03013 RNA transport EIF2S3B 184.3375396 209.1231904 159.5518887 0.762956458 -0.39032737 0.299549023 1 3.521779842 2.64200196 255308 eukaryotic translation initiation factor 2 subunit gamma B "GO:0000049,GO:0001731,GO:0003743,GO:0003924,GO:0005525,GO:0005829,GO:0005850,GO:0045903" tRNA binding|formation of translation preinitiation complex|translation initiation factor activity|GTPase activity|GTP binding|cytosol|eukaryotic translation initiation factor 2 complex|positive regulation of translational fidelity EIF3A 5817.689841 6328.837648 5306.542033 0.838470242 -0.254168513 0.293190473 1 50.72209542 41.81730293 8661 eukaryotic translation initiation factor 3 subunit A "GO:0001732,GO:0002188,GO:0003723,GO:0003729,GO:0003743,GO:0005198,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005852,GO:0005874,GO:0006413,GO:0014069,GO:0016020,GO:0016282,GO:0030971,GO:0033290,GO:0043614,GO:0070373,GO:0071540,GO:0071541,GO:0075522,GO:0075525" "formation of cytoplasmic translation initiation complex|translation reinitiation|RNA binding|mRNA binding|translation initiation factor activity|structural molecule activity|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|eukaryotic translation initiation factor 3 complex|microtubule|translational initiation|postsynaptic density|membrane|eukaryotic 43S preinitiation complex|receptor tyrosine kinase binding|eukaryotic 48S preinitiation complex|multi-eIF complex|negative regulation of ERK1 and ERK2 cascade|eukaryotic translation initiation factor 3 complex, eIF3e|eukaryotic translation initiation factor 3 complex, eIF3m|IRES-dependent viral translational initiation|viral translational termination-reinitiation" hsa03013 RNA transport EIF3B 3029.738256 3045.291434 3014.185078 0.989785425 -0.014812296 0.951597474 1 45.71634511 44.49218513 8662 eukaryotic translation initiation factor 3 subunit B "GO:0001732,GO:0003723,GO:0003743,GO:0005515,GO:0005829,GO:0005852,GO:0006413,GO:0006446,GO:0016282,GO:0031369,GO:0033290,GO:0045202,GO:0060090,GO:0070062,GO:0071541,GO:0075522,GO:0075525" "formation of cytoplasmic translation initiation complex|RNA binding|translation initiation factor activity|protein binding|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|regulation of translational initiation|eukaryotic 43S preinitiation complex|translation initiation factor binding|eukaryotic 48S preinitiation complex|synapse|molecular adaptor activity|extracellular exosome|eukaryotic translation initiation factor 3 complex, eIF3m|IRES-dependent viral translational initiation|viral translational termination-reinitiation" hsa03013 RNA transport EIF3C 513.2542086 504.6007331 521.9076841 1.034298307 0.048652341 0.864802254 1 8.172872142 8.311735172 8663 eukaryotic translation initiation factor 3 subunit C "GO:0001732,GO:0003723,GO:0003743,GO:0005515,GO:0005829,GO:0005852,GO:0006413,GO:0016282,GO:0031369,GO:0033290,GO:0043022,GO:0045727,GO:1902416" formation of cytoplasmic translation initiation complex|RNA binding|translation initiation factor activity|protein binding|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|eukaryotic 43S preinitiation complex|translation initiation factor binding|eukaryotic 48S preinitiation complex|ribosome binding|positive regulation of translation|positive regulation of mRNA binding hsa03013 RNA transport EIF3CL 147.3581873 146.6983575 148.0180172 1.008995737 0.012920078 0.993843274 1 2.394196244 2.375309769 728689 eukaryotic translation initiation factor 3 subunit C like "GO:0001732,GO:0003743,GO:0005515,GO:0005852,GO:0006413,GO:0016282,GO:0031369,GO:0033290" formation of cytoplasmic translation initiation complex|translation initiation factor activity|protein binding|eukaryotic translation initiation factor 3 complex|translational initiation|eukaryotic 43S preinitiation complex|translation initiation factor binding|eukaryotic 48S preinitiation complex hsa03013 RNA transport EIF3D 8605.500342 8372.210514 8838.790171 1.055729566 0.078240323 0.752745405 1 237.6646211 246.7109354 8664 eukaryotic translation initiation factor 3 subunit D "GO:0001732,GO:0002191,GO:0003723,GO:0003743,GO:0005515,GO:0005829,GO:0005852,GO:0006413,GO:0016020,GO:0016282,GO:0033290,GO:0045727,GO:0071541,GO:0075522,GO:0075525,GO:0098808,GO:1902416" "formation of cytoplasmic translation initiation complex|cap-dependent translational initiation|RNA binding|translation initiation factor activity|protein binding|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|membrane|eukaryotic 43S preinitiation complex|eukaryotic 48S preinitiation complex|positive regulation of translation|eukaryotic translation initiation factor 3 complex, eIF3m|IRES-dependent viral translational initiation|viral translational termination-reinitiation|mRNA cap binding|positive regulation of mRNA binding" hsa03013 RNA transport EIF3E 11672.91618 11536.10913 11809.72323 1.023718058 0.033818437 0.894837898 1 255.5670161 257.2505695 3646 eukaryotic translation initiation factor 3 subunit E "GO:0000184,GO:0000785,GO:0001732,GO:0003723,GO:0003743,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005852,GO:0006413,GO:0006446,GO:0016020,GO:0016282,GO:0016605,GO:0033290,GO:0045296,GO:0045727,GO:0045947,GO:0047485,GO:0070062,GO:0071540,GO:1902416" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|chromatin|formation of cytoplasmic translation initiation complex|RNA binding|translation initiation factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|regulation of translational initiation|membrane|eukaryotic 43S preinitiation complex|PML body|eukaryotic 48S preinitiation complex|cadherin binding|positive regulation of translation|negative regulation of translational initiation|protein N-terminus binding|extracellular exosome|eukaryotic translation initiation factor 3 complex, eIF3e|positive regulation of mRNA binding" "hsa03013,hsa05160" RNA transport|Hepatitis C EIF3F 5321.288501 5345.646529 5296.930473 0.990886779 -0.013207873 0.957066729 1 41.22649283 40.16720412 8665 eukaryotic translation initiation factor 3 subunit F "GO:0001732,GO:0003743,GO:0004843,GO:0005515,GO:0005829,GO:0005852,GO:0006413,GO:0008234,GO:0008237,GO:0016020,GO:0016282,GO:0016579,GO:0018215,GO:0031369,GO:0033290,GO:0042802,GO:0070122,GO:0071541,GO:0075522,GO:0101005" "formation of cytoplasmic translation initiation complex|translation initiation factor activity|thiol-dependent ubiquitin-specific protease activity|protein binding|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|cysteine-type peptidase activity|metallopeptidase activity|membrane|eukaryotic 43S preinitiation complex|protein deubiquitination|protein phosphopantetheinylation|translation initiation factor binding|eukaryotic 48S preinitiation complex|identical protein binding|isopeptidase activity|eukaryotic translation initiation factor 3 complex, eIF3m|IRES-dependent viral translational initiation|ubiquitinyl hydrolase activity" hsa03013 RNA transport EIF3G 2120.034825 2074.585282 2165.484369 1.043815546 0.061866794 0.79521627 1 100.3778818 103.0227091 8666 eukaryotic translation initiation factor 3 subunit G "GO:0001732,GO:0003723,GO:0003743,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005852,GO:0006413,GO:0016282,GO:0033290,GO:0048471,GO:0075525" formation of cytoplasmic translation initiation complex|RNA binding|translation initiation factor activity|protein binding|nucleus|cytoplasm|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|eukaryotic 43S preinitiation complex|eukaryotic 48S preinitiation complex|perinuclear region of cytoplasm|viral translational termination-reinitiation hsa03013 RNA transport EIF3H 7993.345836 7920.670889 8066.020783 1.018350705 0.02623449 0.915792614 1 106.7184165 106.858216 8667 eukaryotic translation initiation factor 3 subunit H "GO:0001732,GO:0003723,GO:0003743,GO:0005515,GO:0005829,GO:0005852,GO:0006413,GO:0006446,GO:0006508,GO:0008237,GO:0016020,GO:0016282,GO:0018215,GO:0032435,GO:0033290,GO:0042788,GO:0070062,GO:0070122,GO:0101005" formation of cytoplasmic translation initiation complex|RNA binding|translation initiation factor activity|protein binding|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|regulation of translational initiation|proteolysis|metallopeptidase activity|membrane|eukaryotic 43S preinitiation complex|protein phosphopantetheinylation|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|eukaryotic 48S preinitiation complex|polysomal ribosome|extracellular exosome|isopeptidase activity|ubiquitinyl hydrolase activity "hsa03013,hsa05162" RNA transport|Measles EIF3I 3764.618171 3551.972995 3977.263346 1.119733554 0.163155477 0.492826088 1 98.78179808 108.7583971 8668 eukaryotic translation initiation factor 3 subunit I "GO:0001732,GO:0002183,GO:0003723,GO:0003743,GO:0005515,GO:0005829,GO:0005852,GO:0006413,GO:0016282,GO:0033290,GO:0070062,GO:0071541" "formation of cytoplasmic translation initiation complex|cytoplasmic translational initiation|RNA binding|translation initiation factor activity|protein binding|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|eukaryotic 43S preinitiation complex|eukaryotic 48S preinitiation complex|extracellular exosome|eukaryotic translation initiation factor 3 complex, eIF3m" hsa03013 RNA transport EIF3J 980.8333876 1059.141333 902.5254427 0.852129376 -0.230855608 0.349098806 1 22.80130145 19.10452975 8669 eukaryotic translation initiation factor 3 subunit J "GO:0001732,GO:0003743,GO:0005515,GO:0005829,GO:0005852,GO:0006413,GO:0016282,GO:0033290,GO:0042802" formation of cytoplasmic translation initiation complex|translation initiation factor activity|protein binding|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|eukaryotic 43S preinitiation complex|eukaryotic 48S preinitiation complex|identical protein binding hsa03013 RNA transport EIF3K 1911.688509 1815.522225 2007.854792 1.105937875 0.145270346 0.540386549 1 127.153654 138.2708891 27335 eukaryotic translation initiation factor 3 subunit K "GO:0001732,GO:0003743,GO:0005515,GO:0005634,GO:0005829,GO:0005852,GO:0006413,GO:0006446,GO:0016020,GO:0016282,GO:0033290,GO:0043022" formation of cytoplasmic translation initiation complex|translation initiation factor activity|protein binding|nucleus|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|regulation of translational initiation|membrane|eukaryotic 43S preinitiation complex|eukaryotic 48S preinitiation complex|ribosome binding EIF3L 11656.98361 12215.4994 11098.46782 0.908556209 -0.138352323 0.587616048 1 202.4592396 180.8675188 51386 eukaryotic translation initiation factor 3 subunit L "GO:0001732,GO:0003723,GO:0003743,GO:0005515,GO:0005829,GO:0005852,GO:0006413,GO:0016020,GO:0016282,GO:0033290,GO:0075525" formation of cytoplasmic translation initiation complex|RNA binding|translation initiation factor activity|protein binding|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|membrane|eukaryotic 43S preinitiation complex|eukaryotic 48S preinitiation complex|viral translational termination-reinitiation EIF3M 4783.295759 4216.797466 5349.794051 1.268686508 0.343335623 0.15205535 1 43.78263242 54.61694065 10480 eukaryotic translation initiation factor 3 subunit M "GO:0001732,GO:0002183,GO:0003743,GO:0005515,GO:0005829,GO:0005852,GO:0006413,GO:0016032,GO:0016282,GO:0031369,GO:0033290,GO:0071541" "formation of cytoplasmic translation initiation complex|cytoplasmic translational initiation|translation initiation factor activity|protein binding|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|viral process|eukaryotic 43S preinitiation complex|translation initiation factor binding|eukaryotic 48S preinitiation complex|eukaryotic translation initiation factor 3 complex, eIF3m" EIF4A1 18195.90507 17241.73886 19150.07127 1.110680971 0.151444481 0.574094739 1 523.4129205 571.6167534 1973 eukaryotic translation initiation factor 4A1 "GO:0000339,GO:0002183,GO:0003723,GO:0003724,GO:0003725,GO:0003729,GO:0003743,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006413,GO:0008135,GO:0016020,GO:0016032,GO:0016281,GO:0070062" "RNA cap binding|cytoplasmic translational initiation|RNA binding|RNA helicase activity|double-stranded RNA binding|mRNA binding|translation initiation factor activity|helicase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|translational initiation|translation factor activity, RNA binding|membrane|viral process|eukaryotic translation initiation factor 4F complex|extracellular exosome" hsa03013 RNA transport EIF4A2 9215.863827 7603.344654 10828.383 1.424160484 0.510111728 0.041281552 1 215.1519246 301.2834981 1974 eukaryotic translation initiation factor 4A2 "GO:0002183,GO:0003723,GO:0003724,GO:0003743,GO:0004386,GO:0005515,GO:0005524,GO:0005829,GO:0006413,GO:0006446,GO:0016032,GO:0016281,GO:0016887,GO:0048471,GO:1900260,GO:1990830" cytoplasmic translational initiation|RNA binding|RNA helicase activity|translation initiation factor activity|helicase activity|protein binding|ATP binding|cytosol|translational initiation|regulation of translational initiation|viral process|eukaryotic translation initiation factor 4F complex|ATPase activity|perinuclear region of cytoplasm|negative regulation of RNA-directed 5'-3' RNA polymerase activity|cellular response to leukemia inhibitory factor hsa03013 RNA transport EIF4A3 2422.331622 2339.890822 2504.772421 1.07046551 0.098238313 0.678715172 1 49.47530612 52.07536798 9775 eukaryotic translation initiation factor 4A3 "GO:0000184,GO:0000398,GO:0003723,GO:0003724,GO:0003729,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0006405,GO:0006406,GO:0008143,GO:0008306,GO:0014070,GO:0016020,GO:0016607,GO:0017148,GO:0030425,GO:0031124,GO:0035145,GO:0035368,GO:0035613,GO:0035640,GO:0043021,GO:0043025,GO:0045182,GO:0045727,GO:0048701,GO:0071006,GO:0071013,GO:0072715,GO:0090394,GO:0098978,GO:0099524,GO:0099578,GO:1904570,GO:1904574,GO:1990416" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|RNA binding|RNA helicase activity|mRNA binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|RNA export from nucleus|mRNA export from nucleus|poly(A) binding|associative learning|response to organic cyclic compound|membrane|nuclear speck|negative regulation of translation|dendrite|mRNA 3'-end processing|exon-exon junction complex|selenocysteine insertion sequence binding|RNA stem-loop binding|exploration behavior|ribonucleoprotein complex binding|neuronal cell body|translation regulator activity|positive regulation of translation|embryonic cranial skeleton morphogenesis|U2-type catalytic step 1 spliceosome|catalytic step 2 spliceosome|cellular response to selenite ion|negative regulation of excitatory postsynaptic potential|glutamatergic synapse|postsynaptic cytosol|regulation of translation at postsynapse, modulating synaptic transmission|negative regulation of selenocysteine incorporation|negative regulation of selenocysteine insertion sequence binding|cellular response to brain-derived neurotrophic factor stimulus" "hsa03013,hsa03015,hsa03040" RNA transport|mRNA surveillance pathway|Spliceosome EIF4B 20188.93797 21028.8454 19349.03055 0.920118541 -0.120108356 0.6606629 1 291.0453396 263.3150063 1975 eukaryotic translation initiation factor 4B "GO:0001731,GO:0003723,GO:0003743,GO:0005515,GO:0005829,GO:0006413,GO:0006446,GO:0016281,GO:0033592,GO:0034057,GO:0043024,GO:0097010" formation of translation preinitiation complex|RNA binding|translation initiation factor activity|protein binding|cytosol|translational initiation|regulation of translational initiation|eukaryotic translation initiation factor 4F complex|RNA strand annealing activity|RNA strand-exchange activity|ribosomal small subunit binding|eukaryotic translation initiation factor 4F complex assembly "hsa03013,hsa04150,hsa04151,hsa05205" RNA transport|mTOR signaling pathway|PI3K-Akt signaling pathway|Proteoglycans in cancer EIF4E 939.5791378 871.8668337 1007.291442 1.15532717 0.208301458 0.400565427 1 15.49964373 17.60750747 1977 eukaryotic translation initiation factor 4E "GO:0000082,GO:0000339,GO:0000340,GO:0000932,GO:0001662,GO:0003723,GO:0003743,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005845,GO:0006405,GO:0006406,GO:0006413,GO:0006417,GO:0010494,GO:0010507,GO:0016032,GO:0016281,GO:0016442,GO:0017148,GO:0019827,GO:0019899,GO:0030324,GO:0031370,GO:0033391,GO:0036464,GO:0045665,GO:0045931,GO:0048471,GO:0070062,GO:0070491,GO:0071549,GO:0098978,GO:0099524,GO:0099578" "G1/S transition of mitotic cell cycle|RNA cap binding|RNA 7-methylguanosine cap binding|P-body|behavioral fear response|RNA binding|translation initiation factor activity|protein binding|nucleus|cytoplasm|cytosol|mRNA cap binding complex|RNA export from nucleus|mRNA export from nucleus|translational initiation|regulation of translation|cytoplasmic stress granule|negative regulation of autophagy|viral process|eukaryotic translation initiation factor 4F complex|RISC complex|negative regulation of translation|stem cell population maintenance|enzyme binding|lung development|eukaryotic initiation factor 4G binding|chromatoid body|cytoplasmic ribonucleoprotein granule|negative regulation of neuron differentiation|positive regulation of mitotic cell cycle|perinuclear region of cytoplasm|extracellular exosome|repressing transcription factor binding|cellular response to dexamethasone stimulus|glutamatergic synapse|postsynaptic cytosol|regulation of translation at postsynapse, modulating synaptic transmission" "hsa01521,hsa03013,hsa04066,hsa04150,hsa04151,hsa04211,hsa04910" EGFR tyrosine kinase inhibitor resistance|RNA transport|HIF-1 signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Longevity regulating pathway|Insulin signaling pathway EIF4E2 1101.418831 1058.100919 1144.736744 1.081878603 0.113538624 0.643613425 1 14.335847 15.2501132 9470 eukaryotic translation initiation factor 4E family member 2 "GO:0000339,GO:0000340,GO:0000932,GO:0003723,GO:0003743,GO:0005515,GO:0005737,GO:0005829,GO:0005845,GO:0006413,GO:0008135,GO:0016281,GO:0017148,GO:0031047,GO:0031625,GO:1905618" "RNA cap binding|RNA 7-methylguanosine cap binding|P-body|RNA binding|translation initiation factor activity|protein binding|cytoplasm|cytosol|mRNA cap binding complex|translational initiation|translation factor activity, RNA binding|eukaryotic translation initiation factor 4F complex|negative regulation of translation|gene silencing by RNA|ubiquitin protein ligase binding|positive regulation of miRNA mediated inhibition of translation" "hsa01521,hsa03013,hsa04066,hsa04150,hsa04151,hsa04211,hsa04910" EGFR tyrosine kinase inhibitor resistance|RNA transport|HIF-1 signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Longevity regulating pathway|Insulin signaling pathway EIF4E3 288.9003635 216.4060876 361.3946395 1.669983703 0.739834024 0.020825456 0.821508434 1.096789664 1.800971169 317649 eukaryotic translation initiation factor 4E family member 3 "GO:0000340,GO:0003743,GO:0005829,GO:0005845,GO:0006413,GO:0006417,GO:0016281" RNA 7-methylguanosine cap binding|translation initiation factor activity|cytosol|mRNA cap binding complex|translational initiation|regulation of translation|eukaryotic translation initiation factor 4F complex EIF4EBP1 1568.894214 1572.065377 1565.723052 0.99596561 -0.005832167 0.983477106 1 101.4488994 99.3488539 1978 eukaryotic translation initiation factor 4E binding protein 1 "GO:0000082,GO:0002931,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0008190,GO:0030324,GO:0030371,GO:0031333,GO:0031929,GO:0032991,GO:0045471,GO:0045931,GO:0045947,GO:0051721,GO:0071456,GO:0098978,GO:0099524,GO:1990928" G1/S transition of mitotic cell cycle|response to ischemia|protein binding|nucleus|cytoplasm|cytosol|eukaryotic initiation factor 4E binding|lung development|translation repressor activity|negative regulation of protein-containing complex assembly|TOR signaling|protein-containing complex|response to ethanol|positive regulation of mitotic cell cycle|negative regulation of translational initiation|protein phosphatase 2A binding|cellular response to hypoxia|glutamatergic synapse|postsynaptic cytosol|response to amino acid starvation "hsa01521,hsa03013,hsa04012,hsa04066,hsa04150,hsa04151,hsa04152,hsa04211,hsa04218,hsa04910,hsa05163,hsa05165,hsa05168,hsa05221,hsa05231" EGFR tyrosine kinase inhibitor resistance|RNA transport|ErbB signaling pathway|HIF-1 signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Cellular senescence|Insulin signaling pathway|Human cytomegalovirus infection|Human papillomavirus infection|Herpes simplex virus 1 infection|Acute myeloid leukemia|Choline metabolism in cancer EIF4EBP2 2323.324341 2062.100315 2584.548366 1.253357243 0.325797683 0.168178344 1 14.69102975 18.10499011 1979 eukaryotic translation initiation factor 4E binding protein 2 "GO:0005515,GO:0005737,GO:0006412,GO:0007613,GO:0008190,GO:0008286,GO:0019933,GO:0030371,GO:0031929,GO:0035176,GO:0045947,GO:0048167,GO:0050804,GO:0098794" protein binding|cytoplasm|translation|memory|eukaryotic initiation factor 4E binding|insulin receptor signaling pathway|cAMP-mediated signaling|translation repressor activity|TOR signaling|social behavior|negative regulation of translational initiation|regulation of synaptic plasticity|modulation of chemical synaptic transmission|postsynapse "hsa03013,hsa04213" RNA transport|Longevity regulating pathway - multiple species EIF4EBP3 4.483717655 4.161655531 4.80577978 1.154775965 0.207612985 1 1 0.320490486 0.363901676 8637 eukaryotic translation initiation factor 4E binding protein 3 "GO:0005515,GO:0005737,GO:0008190,GO:0016020,GO:0016281,GO:0030371,GO:0045947" protein binding|cytoplasm|eukaryotic initiation factor 4E binding|membrane|eukaryotic translation initiation factor 4F complex|translation repressor activity|negative regulation of translational initiation hsa03013 RNA transport EIF4ENIF1 585.5384357 610.7229491 560.3539223 0.917525571 -0.12417973 0.642236294 1 5.347524419 4.824386922 56478 eukaryotic translation initiation factor 4E nuclear import factor 1 "GO:0000932,GO:0003723,GO:0003729,GO:0005049,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006606,GO:0016020,GO:0016605,GO:0016607,GO:0017148,GO:0019827,GO:0019900,GO:0031047,GO:0033962,GO:0043231,GO:0045665,GO:0048255,GO:0051168,GO:0060213,GO:0106289,GO:1905618" P-body|RNA binding|mRNA binding|nuclear export signal receptor activity|protein binding|nucleus|cytoplasm|cytosol|protein import into nucleus|membrane|PML body|nuclear speck|negative regulation of translation|stem cell population maintenance|kinase binding|gene silencing by RNA|P-body assembly|intracellular membrane-bounded organelle|negative regulation of neuron differentiation|mRNA stabilization|nuclear export|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA|positive regulation of miRNA mediated inhibition of translation EIF4G1 9184.678752 9560.363168 8808.994337 0.92140792 -0.118088097 0.636024827 1 82.54635351 74.78612177 1981 eukaryotic translation initiation factor 4 gamma 1 "GO:0000184,GO:0001662,GO:0002191,GO:0003723,GO:0003729,GO:0003743,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0006412,GO:0006413,GO:0006446,GO:0008135,GO:0008190,GO:0010494,GO:0010507,GO:0010801,GO:0010942,GO:0016020,GO:0016032,GO:0016281,GO:0030307,GO:0031369,GO:0031669,GO:0032270,GO:0032502,GO:0033138,GO:0034645,GO:0036493,GO:0042802,GO:0043488,GO:0045666,GO:0060090,GO:0060964,GO:0080135,GO:0097009,GO:1900087,GO:1901215,GO:1905537,GO:1905606,GO:1905612,GO:1905618,GO:1905696" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|behavioral fear response|cap-dependent translational initiation|RNA binding|mRNA binding|translation initiation factor activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|polysome|translation|translational initiation|regulation of translational initiation|translation factor activity, RNA binding|eukaryotic initiation factor 4E binding|cytoplasmic stress granule|negative regulation of autophagy|negative regulation of peptidyl-threonine phosphorylation|positive regulation of cell death|membrane|viral process|eukaryotic translation initiation factor 4F complex|positive regulation of cell growth|translation initiation factor binding|cellular response to nutrient levels|positive regulation of cellular protein metabolic process|developmental process|positive regulation of peptidyl-serine phosphorylation|cellular macromolecule biosynthetic process|positive regulation of translation in response to endoplasmic reticulum stress|identical protein binding|regulation of mRNA stability|positive regulation of neuron differentiation|molecular adaptor activity|regulation of gene silencing by miRNA|regulation of cellular response to stress|energy homeostasis|positive regulation of G1/S transition of mitotic cell cycle|negative regulation of neuron death|positive regulation of eukaryotic translation initiation factor 4F complex assembly|regulation of presynapse assembly|positive regulation of mRNA cap binding|positive regulation of miRNA mediated inhibition of translation|regulation of polysome binding" "hsa03013,hsa05416" RNA transport|Viral myocarditis EIF4G2 14495.29762 14550.18815 14440.40708 0.992455007 -0.010926396 0.966936388 1 182.7098351 178.2969572 1982 eukaryotic translation initiation factor 4 gamma 2 "GO:0003723,GO:0003729,GO:0003743,GO:0005515,GO:0005829,GO:0005912,GO:0006413,GO:0006446,GO:0007050,GO:0007507,GO:0008135,GO:0008219,GO:0010507,GO:0016020,GO:0016281,GO:0030307,GO:0030424,GO:0034645,GO:0045296,GO:0045727,GO:0045773,GO:0060999" "RNA binding|mRNA binding|translation initiation factor activity|protein binding|cytosol|adherens junction|translational initiation|regulation of translational initiation|cell cycle arrest|heart development|translation factor activity, RNA binding|cell death|negative regulation of autophagy|membrane|eukaryotic translation initiation factor 4F complex|positive regulation of cell growth|axon|cellular macromolecule biosynthetic process|cadherin binding|positive regulation of translation|positive regulation of axon extension|positive regulation of dendritic spine development" "hsa03013,hsa05416" RNA transport|Viral myocarditis EIF4G3 2402.186976 2340.931236 2463.442715 1.052334506 0.073593367 0.756812464 1 14.53871728 15.04357588 8672 eukaryotic translation initiation factor 4 gamma 3 "GO:0000339,GO:0003723,GO:0003729,GO:0003743,GO:0005829,GO:0006413,GO:0006446,GO:0008135,GO:0010507,GO:0016281" "RNA cap binding|RNA binding|mRNA binding|translation initiation factor activity|cytosol|translational initiation|regulation of translational initiation|translation factor activity, RNA binding|negative regulation of autophagy|eukaryotic translation initiation factor 4F complex" "hsa03013,hsa05416" RNA transport|Viral myocarditis EIF4H 8858.556731 8391.978377 9325.135085 1.111196272 0.152113664 0.540825648 1 174.7422794 190.9237477 7458 eukaryotic translation initiation factor 4H "GO:0001731,GO:0003723,GO:0003743,GO:0005515,GO:0005829,GO:0006413,GO:0006446,GO:0008135,GO:0016020,GO:0016032,GO:0016281,GO:0019953,GO:0033592,GO:0034057,GO:0043024,GO:0045296,GO:0048471,GO:0048589,GO:0097010" "formation of translation preinitiation complex|RNA binding|translation initiation factor activity|protein binding|cytosol|translational initiation|regulation of translational initiation|translation factor activity, RNA binding|membrane|viral process|eukaryotic translation initiation factor 4F complex|sexual reproduction|RNA strand annealing activity|RNA strand-exchange activity|ribosomal small subunit binding|cadherin binding|perinuclear region of cytoplasm|developmental growth|eukaryotic translation initiation factor 4F complex assembly" EIF5 4215.099219 4995.027051 3435.171387 0.687718275 -0.540110412 0.023790164 0.848442542 44.37007544 30.0034994 1983 eukaryotic translation initiation factor 5 "GO:0001731,GO:0001732,GO:0003723,GO:0003743,GO:0005092,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006446,GO:0045296,GO:0071074,GO:0090630" formation of translation preinitiation complex|formation of cytoplasmic translation initiation complex|RNA binding|translation initiation factor activity|GDP-dissociation inhibitor activity|protein binding|GTP binding|nucleus|cytoplasm|cytosol|plasma membrane|regulation of translational initiation|cadherin binding|eukaryotic initiation factor eIF2 binding|activation of GTPase activity hsa03013 RNA transport EIF5A 7765.604021 7493.060783 8038.14726 1.072745503 0.101307854 0.680890126 1 110.7117614 116.7781637 1984 eukaryotic translation initiation factor 5A "GO:0003723,GO:0003746,GO:0005515,GO:0005634,GO:0005642,GO:0005643,GO:0005737,GO:0005789,GO:0005829,GO:0006406,GO:0006414,GO:0006611,GO:0006913,GO:0006915,GO:0008284,GO:0016020,GO:0017070,GO:0043022,GO:0045901,GO:0045905,GO:0047485" RNA binding|translation elongation factor activity|protein binding|nucleus|annulate lamellae|nuclear pore|cytoplasm|endoplasmic reticulum membrane|cytosol|mRNA export from nucleus|translational elongation|protein export from nucleus|nucleocytoplasmic transport|apoptotic process|positive regulation of cell population proliferation|membrane|U6 snRNA binding|ribosome binding|positive regulation of translational elongation|positive regulation of translational termination|protein N-terminus binding EIF5A2 1397.463083 1335.891425 1459.034741 1.092180632 0.127211478 0.596869142 1 12.88291834 13.83502357 56648 eukaryotic translation initiation factor 5A2 "GO:0003746,GO:0005515,GO:0005643,GO:0005789,GO:0005829,GO:0006414,GO:0007283,GO:0008284,GO:0010509,GO:0015031,GO:0043022,GO:0043231,GO:0045901,GO:0045905,GO:0051028" translation elongation factor activity|protein binding|nuclear pore|endoplasmic reticulum membrane|cytosol|translational elongation|spermatogenesis|positive regulation of cell population proliferation|polyamine homeostasis|protein transport|ribosome binding|intracellular membrane-bounded organelle|positive regulation of translational elongation|positive regulation of translational termination|mRNA transport EIF5AL1 249.7999402 249.6993318 249.9005486 1.000805836 0.001162108 1 1 3.409926922 3.355568274 143244 eukaryotic translation initiation factor 5A like 1 "GO:0003746,GO:0005643,GO:0005789,GO:0006414,GO:0015031,GO:0043022,GO:0045901,GO:0045905,GO:0051028" translation elongation factor activity|nuclear pore|endoplasmic reticulum membrane|translational elongation|protein transport|ribosome binding|positive regulation of translational elongation|positive regulation of translational termination|mRNA transport EIF5B 2627.567372 2466.821316 2788.313428 1.130326469 0.176739523 0.455125169 1 22.93149622 25.48633977 9669 eukaryotic translation initiation factor 5B "GO:0003723,GO:0003743,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005829,GO:0006413,GO:0006446,GO:0046872" RNA binding|translation initiation factor activity|GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|cytosol|translational initiation|regulation of translational initiation|metal ion binding hsa03013 RNA transport EIF6 2987.289493 2940.209632 3034.369353 1.032024832 0.045477685 0.848897506 1 128.512354 130.4085916 3692 eukaryotic translation initiation factor 6 "GO:0000054,GO:0000460,GO:0000470,GO:0003743,GO:0005515,GO:0005634,GO:0005638,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006110,GO:0006413,GO:0030687,GO:0032868,GO:0035195,GO:0035278,GO:0042256,GO:0042304,GO:0043022,GO:0043023,GO:0045652,GO:0045727,GO:0070062,GO:1902626,GO:2000377" "ribosomal subunit export from nucleus|maturation of 5.8S rRNA|maturation of LSU-rRNA|translation initiation factor activity|protein binding|nucleus|lamin filament|nucleoplasm|nucleolus|cytoplasm|cytosol|regulation of glycolytic process|translational initiation|preribosome, large subunit precursor|response to insulin|gene silencing by miRNA|miRNA mediated inhibition of translation|mature ribosome assembly|regulation of fatty acid biosynthetic process|ribosome binding|ribosomal large subunit binding|regulation of megakaryocyte differentiation|positive regulation of translation|extracellular exosome|assembly of large subunit precursor of preribosome|regulation of reactive oxygen species metabolic process" hsa03008 Ribosome biogenesis in eukaryotes EIPR1 376.7907989 353.7407201 399.8408777 1.130321885 0.176733672 0.552188059 1 7.023248543 7.805690961 7260 EARP complex and GARP complex interacting protein 1 "GO:0000938,GO:0005515,GO:0005802,GO:0016567,GO:0032456,GO:0050796,GO:1905281,GO:1990745,GO:2001137" "GARP complex|protein binding|trans-Golgi network|protein ubiquitination|endocytic recycling|regulation of insulin secretion|positive regulation of retrograde transport, endosome to Golgi|EARP complex|positive regulation of endocytic recycling" ELAC1 53.43789036 65.54607461 41.32970611 0.630544336 -0.665330279 0.257895002 1 1.58212281 0.980905116 55520 elaC ribonuclease Z 1 "GO:0005634,GO:0005654,GO:0005829,GO:0034414,GO:0042781,GO:0046872" "nucleus|nucleoplasm|cytosol|tRNA 3'-trailer cleavage, endonucleolytic|3'-tRNA processing endoribonuclease activity|metal ion binding" hsa03013 RNA transport ELAC2 1819.744629 1798.875603 1840.613656 1.023202301 0.033091413 0.891242384 1 23.67513804 23.81909225 60528 elaC ribonuclease Z 2 "GO:0003723,GO:0004549,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0042645,GO:0042780,GO:0042781,GO:0046872,GO:0072684,GO:0090646" "RNA binding|tRNA-specific ribonuclease activity|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|mitochondrial nucleoid|tRNA 3'-end processing|3'-tRNA processing endoribonuclease activity|metal ion binding|mitochondrial tRNA 3'-trailer cleavage, endonucleolytic|mitochondrial tRNA processing" hsa03013 RNA transport ELAPOR1 25.17813884 30.1720026 20.18427508 0.668973662 -0.579978682 0.472259925 1 0.19482448 0.128151509 57535 endosome-lysosome associated apoptosis and autophagy regulator 1 "GO:0000045,GO:0003723,GO:0005764,GO:0005765,GO:0005770,GO:0005789,GO:0005802,GO:0005886,GO:0005887,GO:0009267,GO:0016021,GO:0031902,GO:0044090,GO:0070062,GO:2000786" autophagosome assembly|RNA binding|lysosome|lysosomal membrane|late endosome|endoplasmic reticulum membrane|trans-Golgi network|plasma membrane|integral component of plasma membrane|cellular response to starvation|integral component of membrane|late endosome membrane|positive regulation of vacuole organization|extracellular exosome|positive regulation of autophagosome assembly ELAPOR2 1068.601134 1003.999397 1133.202872 1.128688798 0.174647761 0.476137763 1 6.380281321 7.08084718 222223 endosome-lysosome associated apoptosis and autophagy regulator family member 2 "GO:0005886,GO:0016021,GO:0030513,GO:0045684,GO:0051961,GO:0070700" plasma membrane|integral component of membrane|positive regulation of BMP signaling pathway|positive regulation of epidermis development|negative regulation of nervous system development|BMP receptor binding ELAVL1 2124.310952 1997.594655 2251.027249 1.126868879 0.172319655 0.466689146 1 17.60950699 19.51154953 1994 ELAV like RNA binding protein 1 "GO:0000398,GO:0003723,GO:0003725,GO:0003729,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0006606,GO:0010494,GO:0016020,GO:0016441,GO:0019901,GO:0035198,GO:0035925,GO:0042803,GO:0043488,GO:0045727,GO:0048255,GO:0051260,GO:0060965,GO:0070935,GO:0098794,GO:0098978,GO:1990904,GO:2000036" "mRNA splicing, via spliceosome|RNA binding|double-stranded RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|protein import into nucleus|cytoplasmic stress granule|membrane|posttranscriptional gene silencing|protein kinase binding|miRNA binding|mRNA 3'-UTR AU-rich region binding|protein homodimerization activity|regulation of mRNA stability|positive regulation of translation|mRNA stabilization|protein homooligomerization|negative regulation of gene silencing by miRNA|3'-UTR-mediated mRNA stabilization|postsynapse|glutamatergic synapse|ribonucleoprotein complex|regulation of stem cell population maintenance" "hsa04152,hsa04657" AMPK signaling pathway|IL-17 signaling pathway ELAVL2 51.12431923 42.65696919 59.59166927 1.396997265 0.482329196 0.427194428 1 0.358112953 0.491911261 1993 ELAV like RNA binding protein 2 "GO:0000398,GO:0003723,GO:0003730,GO:0005515,GO:0005654,GO:0006355,GO:1990904" "mRNA splicing, via spliceosome|RNA binding|mRNA 3'-UTR binding|protein binding|nucleoplasm|regulation of transcription, DNA-templated|ribonucleoprotein complex" ELF1 1055.699142 1119.485338 991.9129466 0.886043714 -0.174550217 0.476765744 1 12.70897148 11.07227166 1997 E74 like ETS transcription factor 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001959,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0030154,GO:0045893,GO:0045944,GO:0050855,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|regulation of cytokine-mediated signaling pathway|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of B cell receptor signaling pathway|sequence-specific double-stranded DNA binding" ETS ELF2 477.3347776 495.2370081 459.432547 0.927702372 -0.108266065 0.700513113 1 5.778287914 5.270830168 1998 E74 like ETS transcription factor 2 "GO:0000785,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0016604,GO:0030154,GO:0045893,GO:0050855,GO:1990837" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|nuclear body|cell differentiation|positive regulation of transcription, DNA-templated|regulation of B cell receptor signaling pathway|sequence-specific double-stranded DNA binding" ETS ELF3 96.09988996 138.3750464 53.82473354 0.388977167 -1.362242623 0.004485855 0.412329403 2.30487575 0.881541589 1999 E74 like ETS transcription factor 3 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001824,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006357,GO:0006366,GO:0006954,GO:0030154,GO:0030198,GO:0030855,GO:0045747,GO:0045892,GO:0045944,GO:0060056,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|blastocyst development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|Golgi apparatus|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|inflammatory response|cell differentiation|extracellular matrix organization|epithelial cell differentiation|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|mammary gland involution|sequence-specific double-stranded DNA binding" ETS ELF4 2681.846303 2731.086442 2632.606163 0.963940988 -0.052983267 0.824023328 1 24.57064462 23.28832089 2000 E74 like ETS transcription factor 4 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001787,GO:0001866,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0016604,GO:0016605,GO:0030154,GO:0045087,GO:0045893,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|natural killer cell proliferation|NK T cell proliferation|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|nuclear body|PML body|cell differentiation|innate immune response|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" ELFN1 5.965080553 5.202069413 6.728091692 1.29334908 0.371111717 0.919461532 1 0.028952433 0.036819002 392617 extracellular leucine rich repeat and fibronectin type III domain containing 1 "GO:0004864,GO:0005615,GO:0010923,GO:0016021,GO:0030425,GO:0031012,GO:0032515,GO:0050808,GO:0060076" protein phosphatase inhibitor activity|extracellular space|negative regulation of phosphatase activity|integral component of membrane|dendrite|extracellular matrix|negative regulation of phosphoprotein phosphatase activity|synapse organization|excitatory synapse ELFN2 1669.954598 1525.246752 1814.662445 1.18975008 0.250658551 0.291677761 1 9.725163186 11.3768968 114794 extracellular leucine rich repeat and fibronectin type III domain containing 2 "GO:0004864,GO:0005615,GO:0010923,GO:0016021,GO:0031012,GO:0032515" protein phosphatase inhibitor activity|extracellular space|negative regulation of phosphatase activity|integral component of membrane|extracellular matrix|negative regulation of phosphoprotein phosphatase activity ELK1 1618.135851 1615.76276 1620.508942 1.002937425 0.004231597 0.988766825 1 29.97229365 29.55731602 2002 ETS transcription factor ELK1 "GO:0000785,GO:0000978,GO:0000981,GO:0001085,GO:0001228,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006357,GO:0009416,GO:0030154,GO:0030425,GO:0043025,GO:0043679,GO:0045893,GO:0045944,GO:0071394,GO:0071480,GO:0071774,GO:1901216,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|response to light stimulus|cell differentiation|dendrite|neuronal cell body|axon terminus|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cellular response to testosterone stimulus|cellular response to gamma radiation|response to fibroblast growth factor|positive regulation of neuron death|sequence-specific double-stranded DNA binding" "hsa04010,hsa04012,hsa04014,hsa04510,hsa04910,hsa04912,hsa04921,hsa05140,hsa05161,hsa05163,hsa05166,hsa05200,hsa05205,hsa05213,hsa05225" MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Focal adhesion|Insulin signaling pathway|GnRH signaling pathway|Oxytocin signaling pathway|Leishmaniasis|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Endometrial cancer|Hepatocellular carcinoma ETS ELK3 8673.650524 8003.903999 9343.397048 1.167354962 0.223243313 0.368576573 1 97.72446714 112.1701817 2004 ETS transcription factor ELK3 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0001525,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006357,GO:0007165,GO:0030154,GO:0032422,GO:0042060,GO:0045892,GO:0045944,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|signal transduction|cell differentiation|purine-rich negative regulatory element binding|wound healing|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" ETS ELK4 999.154487 1111.162027 887.1469474 0.798395667 -0.324824204 0.186379597 1 5.005543609 3.929529914 2005 ETS transcription factor ELK4 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0030154,GO:0045944,GO:0070932,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|cell differentiation|positive regulation of transcription by RNA polymerase II|histone H3 deacetylation|sequence-specific double-stranded DNA binding" "hsa04010,hsa05166,hsa05202" MAPK signaling pathway|Human T-cell leukemia virus 1 infection|Transcriptional misregulation in cancer ETS ELL 405.1694373 392.2360338 418.1028409 1.065947044 0.092135768 0.756070722 1 4.240866334 4.444893837 8178 elongation factor for RNA polymerase II "GO:0001701,GO:0005515,GO:0005654,GO:0005829,GO:0006366,GO:0006368,GO:0008023,GO:0010923,GO:0015030,GO:0016604,GO:0016607,GO:0019902,GO:0032786,GO:0032968,GO:0035327,GO:0035363,GO:0042795,GO:0042796,GO:0045945" "in utero embryonic development|protein binding|nucleoplasm|cytosol|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|transcription elongation factor complex|negative regulation of phosphatase activity|Cajal body|nuclear body|nuclear speck|phosphatase binding|positive regulation of DNA-templated transcription, elongation|positive regulation of transcription elongation from RNA polymerase II promoter|transcriptionally active chromatin|histone locus body|snRNA transcription by RNA polymerase II|snRNA transcription by RNA polymerase III|positive regulation of transcription by RNA polymerase III" ELL2 3458.731459 2952.694599 3964.768318 1.34276275 0.42520442 0.073370763 1 21.34939492 28.18746592 22936 elongation factor for RNA polymerase II 2 "GO:0005515,GO:0005654,GO:0006368,GO:0008023,GO:0042795" protein binding|nucleoplasm|transcription elongation from RNA polymerase II promoter|transcription elongation factor complex|snRNA transcription by RNA polymerase II other ELL3 24.09809599 27.05076095 21.14543103 0.781694499 -0.355323209 0.687544819 1 0.822592248 0.632255836 80237 elongation factor for RNA polymerase II 3 "GO:0000987,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005829,GO:0006354,GO:0006366,GO:0006368,GO:0007283,GO:0008023,GO:0010717,GO:0016607,GO:0030054,GO:0032786,GO:0042795,GO:0045944,GO:0048863,GO:0050769,GO:1902166,GO:2000179" "cis-regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|cytosol|DNA-templated transcription, elongation|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|spermatogenesis|transcription elongation factor complex|regulation of epithelial to mesenchymal transition|nuclear speck|cell junction|positive regulation of DNA-templated transcription, elongation|snRNA transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|stem cell differentiation|positive regulation of neurogenesis|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of neural precursor cell proliferation" ELMO2 1530.056717 1549.176271 1510.937163 0.97531649 -0.036057646 0.882434955 1 22.46038857 21.53942031 63916 engulfment and cell motility 2 "GO:0005515,GO:0005829,GO:0006915,GO:0007015,GO:0016020,GO:0017124,GO:0030971,GO:0038096,GO:0048010,GO:0048870,GO:0060326,GO:0098609" protein binding|cytosol|apoptotic process|actin filament organization|membrane|SH3 domain binding|receptor tyrosine kinase binding|Fc-gamma receptor signaling pathway involved in phagocytosis|vascular endothelial growth factor receptor signaling pathway|cell motility|cell chemotaxis|cell-cell adhesion "hsa05100,hsa05131,hsa05132,hsa05135" Bacterial invasion of epithelial cells|Shigellosis|Salmonella infection|Yersinia infection ELMO3 42.27577081 37.45489978 47.09664184 1.257422717 0.330469733 0.626141718 1 0.75344861 0.931549885 79767 engulfment and cell motility 3 "GO:0005515,GO:0005737,GO:0006909,GO:0006915,GO:0007015,GO:0016477,GO:0017124,GO:0048870" protein binding|cytoplasm|phagocytosis|apoptotic process|actin filament organization|cell migration|SH3 domain binding|cell motility hsa05100 Bacterial invasion of epithelial cells ELMOD1 70.84752362 93.63724944 48.0577978 0.513233762 -0.962312016 0.068710875 1 1.539035388 0.776667268 55531 ELMO domain containing 1 "GO:0005096,GO:0043547" GTPase activator activity|positive regulation of GTPase activity ELMOD2 527.4633423 524.3685969 530.5580877 1.011803702 0.016929423 0.957726511 1 3.374076232 3.356775783 255520 ELMO domain containing 2 "GO:0005096,GO:0016020,GO:0043547,GO:0050688,GO:0051607" GTPase activator activity|membrane|positive regulation of GTPase activity|regulation of defense response to virus|defense response to virus ELMOD3 283.0189569 301.720026 264.3178879 0.876036939 -0.190936392 0.558023083 1 5.740550178 4.944781604 84173 ELMO domain containing 3 "GO:0005096,GO:0005515,GO:0005737,GO:0005856,GO:0005886,GO:0032420,GO:0043547,GO:0060091" GTPase activator activity|protein binding|cytoplasm|cytoskeleton|plasma membrane|stereocilium|positive regulation of GTPase activity|kinocilium ELOA 783.2132718 816.7248979 749.7016457 0.917936563 -0.12353364 0.627253527 1 8.817945928 7.958867579 6924 elongin A "GO:0005515,GO:0005615,GO:0005654,GO:0006357,GO:0006366,GO:0006368,GO:0070449,GO:0090734" protein binding|extracellular space|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|elongin complex|site of DNA damage ELOB 1319.531422 1131.970304 1507.092539 1.331388759 0.412931893 0.085951804 1 62.02379329 81.19595386 6923 elongin B "GO:0005515,GO:0005654,GO:0005829,GO:0006366,GO:0006368,GO:0016032,GO:0016567,GO:0030891,GO:0031462,GO:0031466,GO:0031625,GO:0032436,GO:0043687,GO:0061418,GO:0065003,GO:0070449" protein binding|nucleoplasm|cytosol|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|viral process|protein ubiquitination|VCB complex|Cul2-RING ubiquitin ligase complex|Cul5-RING ubiquitin ligase complex|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|regulation of transcription from RNA polymerase II promoter in response to hypoxia|protein-containing complex assembly|elongin complex "hsa04066,hsa04120,hsa05170,hsa05200,hsa05211" HIF-1 signaling pathway|Ubiquitin mediated proteolysis|Human immunodeficiency virus 1 infection|Pathways in cancer|Renal cell carcinoma ELOC 1935.509816 1734.369942 2136.64969 1.231945756 0.300938734 0.203745858 1 37.99677183 46.02666049 6921 elongin C "GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0006366,GO:0006368,GO:0006511,GO:0016032,GO:0016567,GO:0030891,GO:0031462,GO:0043687,GO:0044877,GO:0061418,GO:0070449" protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|ubiquitin-dependent protein catabolic process|viral process|protein ubiquitination|VCB complex|Cul2-RING ubiquitin ligase complex|post-translational protein modification|protein-containing complex binding|regulation of transcription from RNA polymerase II promoter in response to hypoxia|elongin complex "hsa04066,hsa04120,hsa05170,hsa05200,hsa05211" HIF-1 signaling pathway|Ubiquitin mediated proteolysis|Human immunodeficiency virus 1 infection|Pathways in cancer|Renal cell carcinoma ELOF1 548.6138037 511.8836303 585.3439772 1.143509858 0.193468803 0.472365261 1 17.15972899 19.29396631 84337 elongation factor 1 homolog "GO:0000993,GO:0005515,GO:0006368,GO:0008023,GO:0046872,GO:0048096" RNA polymerase II complex binding|protein binding|transcription elongation from RNA polymerase II promoter|transcription elongation factor complex|metal ion binding|chromatin-mediated maintenance of transcription ELOVL1 2653.771448 2435.608899 2871.933997 1.179144155 0.237740104 0.314826273 1 76.68670826 88.91154915 64834 ELOVL fatty acid elongase 1 "GO:0005515,GO:0005783,GO:0005789,GO:0006636,GO:0009922,GO:0016020,GO:0019367,GO:0030148,GO:0030176,GO:0034625,GO:0034626,GO:0035338,GO:0036109,GO:0042761,GO:0043651,GO:0046513,GO:0061436,GO:0102336,GO:0102337,GO:0102338,GO:0102756" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|fatty acid elongase activity|membrane|fatty acid elongation, saturated fatty acid|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|alpha-linolenic acid metabolic process|very long-chain fatty acid biosynthetic process|linoleic acid metabolic process|ceramide biosynthetic process|establishment of skin barrier|3-oxo-arachidoyl-CoA synthase activity|3-oxo-cerotoyl-CoA synthase activity|3-oxo-lignoceronyl-CoA synthase activity|very-long-chain 3-ketoacyl-CoA synthase activity" "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids ELOVL3 50.40093705 48.89945248 51.90242162 1.061411099 0.085983541 0.920263641 1 1.02500939 1.069750867 83401 ELOVL fatty acid elongase 3 "GO:0005515,GO:0005783,GO:0005789,GO:0006636,GO:0009922,GO:0019367,GO:0030148,GO:0030176,GO:0034625,GO:0034626,GO:0035338,GO:0036109,GO:0042761,GO:0043651,GO:0102336,GO:0102337,GO:0102338,GO:0102756,GO:0120162" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|fatty acid elongase activity|fatty acid elongation, saturated fatty acid|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|alpha-linolenic acid metabolic process|very long-chain fatty acid biosynthetic process|linoleic acid metabolic process|3-oxo-arachidoyl-CoA synthase activity|3-oxo-cerotoyl-CoA synthase activity|3-oxo-lignoceronyl-CoA synthase activity|very-long-chain 3-ketoacyl-CoA synthase activity|positive regulation of cold-induced thermogenesis" "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids ELOVL4 231.8851912 183.1128433 280.6575392 1.532702644 0.61607783 0.073427067 1 3.243410522 4.887997852 6785 ELOVL fatty acid elongase 4 "GO:0005515,GO:0005783,GO:0006633,GO:0006636,GO:0008020,GO:0009584,GO:0009922,GO:0019367,GO:0030148,GO:0030176,GO:0034625,GO:0034626,GO:0035338,GO:0042761,GO:0102336,GO:0102337,GO:0102338,GO:0102756" "protein binding|endoplasmic reticulum|fatty acid biosynthetic process|unsaturated fatty acid biosynthetic process|G protein-coupled photoreceptor activity|detection of visible light|fatty acid elongase activity|fatty acid elongation, saturated fatty acid|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|very long-chain fatty acid biosynthetic process|3-oxo-arachidoyl-CoA synthase activity|3-oxo-cerotoyl-CoA synthase activity|3-oxo-lignoceronyl-CoA synthase activity|very-long-chain 3-ketoacyl-CoA synthase activity" "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids ELOVL5 3005.650221 2993.27074 3018.029702 1.008271541 0.011884228 0.961494452 1 42.97695938 42.60733527 60481 ELOVL fatty acid elongase 5 "GO:0005515,GO:0005783,GO:0005789,GO:0006636,GO:0009922,GO:0016020,GO:0019367,GO:0030148,GO:0030176,GO:0030425,GO:0034625,GO:0034626,GO:0035338,GO:0036109,GO:0042761,GO:0043025,GO:0043651,GO:0045723,GO:0097447,GO:0102336,GO:0102337,GO:0102338,GO:0102756" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|fatty acid elongase activity|membrane|fatty acid elongation, saturated fatty acid|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|dendrite|fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|alpha-linolenic acid metabolic process|very long-chain fatty acid biosynthetic process|neuronal cell body|linoleic acid metabolic process|positive regulation of fatty acid biosynthetic process|dendritic tree|3-oxo-arachidoyl-CoA synthase activity|3-oxo-cerotoyl-CoA synthase activity|3-oxo-lignoceronyl-CoA synthase activity|very-long-chain 3-ketoacyl-CoA synthase activity" "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids ELOVL6 789.8633343 612.8037769 966.9228917 1.577867057 0.657975656 0.009161369 0.589887864 4.892910127 7.591171902 79071 ELOVL fatty acid elongase 6 "GO:0005515,GO:0005783,GO:0005789,GO:0006636,GO:0009922,GO:0009923,GO:0019367,GO:0030148,GO:0030176,GO:0034625,GO:0034626,GO:0035338,GO:0042759,GO:0042761,GO:0045540,GO:0102336,GO:0102337,GO:0102338,GO:0102756,GO:0120162" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|fatty acid elongase activity|fatty acid elongase complex|fatty acid elongation, saturated fatty acid|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|long-chain fatty acid biosynthetic process|very long-chain fatty acid biosynthetic process|regulation of cholesterol biosynthetic process|3-oxo-arachidoyl-CoA synthase activity|3-oxo-cerotoyl-CoA synthase activity|3-oxo-lignoceronyl-CoA synthase activity|very-long-chain 3-ketoacyl-CoA synthase activity|positive regulation of cold-induced thermogenesis" "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids ELOVL7 1056.165243 1056.020091 1056.310396 1.000274905 0.000396549 1 1 9.429120189 9.273885365 79993 ELOVL fatty acid elongase 7 "GO:0005515,GO:0005783,GO:0005789,GO:0006636,GO:0009922,GO:0019367,GO:0030148,GO:0030176,GO:0034625,GO:0034626,GO:0035338,GO:0042761,GO:0102336,GO:0102337,GO:0102338,GO:0102756" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|fatty acid elongase activity|fatty acid elongation, saturated fatty acid|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|very long-chain fatty acid biosynthetic process|3-oxo-arachidoyl-CoA synthase activity|3-oxo-cerotoyl-CoA synthase activity|3-oxo-lignoceronyl-CoA synthase activity|very-long-chain 3-ketoacyl-CoA synthase activity" "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids ELP1 1697.772172 1763.501531 1632.042813 0.925455853 -0.111763924 0.639237957 1 16.42779465 14.94879376 8518 elongator acetyltransferase complex subunit 1 "GO:0000049,GO:0002926,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0033588" tRNA binding|tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation|protein binding|nucleus|cytoplasm|cytosol|elongator holoenzyme complex ELP2 1714.136976 1701.076698 1727.197253 1.015355307 0.021984663 0.928785268 1 10.52316413 10.50595571 55250 elongator acetyltransferase complex subunit 2 "GO:0000993,GO:0002098,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006368,GO:0008023,GO:0019901,GO:0033588,GO:0046425" RNA polymerase II complex binding|tRNA wobble uridine modification|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|transcription elongation factor complex|protein kinase binding|elongator holoenzyme complex|regulation of receptor signaling pathway via JAK-STAT ELP3 463.8093971 468.1862472 459.432547 0.981302953 -0.027229493 0.930228696 1 7.314472928 7.057604563 55140 elongator acetyltransferase complex subunit 3 "GO:0000049,GO:0001764,GO:0002098,GO:0002926,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0006357,GO:0007417,GO:0008080,GO:0008607,GO:0016407,GO:0030335,GO:0033588,GO:0045859,GO:0046872,GO:0051539,GO:0106261" "tRNA binding|neuron migration|tRNA wobble uridine modification|tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation|protein binding|nucleus|nucleolus|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|central nervous system development|N-acetyltransferase activity|phosphorylase kinase regulator activity|acetyltransferase activity|positive regulation of cell migration|elongator holoenzyme complex|regulation of protein kinase activity|metal ion binding|4 iron, 4 sulfur cluster binding|tRNA uridine(34) acetyltransferase activity" ELP4 488.6509969 439.0546585 538.2473354 1.225923299 0.293868718 0.285773424 1 2.748890213 3.313537368 26610 elongator acetyltransferase complex subunit 4 "GO:0000993,GO:0002098,GO:0005515,GO:0005654,GO:0005737,GO:0006357,GO:0006368,GO:0008023,GO:0008607,GO:0033588,GO:0045859" RNA polymerase II complex binding|tRNA wobble uridine modification|protein binding|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|transcription elongation factor complex|phosphorylase kinase regulator activity|elongator holoenzyme complex|regulation of protein kinase activity ELP5 675.5750943 589.9146715 761.2355171 1.290416316 0.367836585 0.153427488 1 17.7767712 22.55557522 23587 elongator acetyltransferase complex subunit 5 "GO:0000049,GO:0002098,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006400,GO:0030335,GO:0033588" tRNA binding|tRNA wobble uridine modification|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|tRNA modification|positive regulation of cell migration|elongator holoenzyme complex ELP6 556.3772789 526.4494246 586.3051332 1.113696978 0.155356748 0.563927151 1 5.772680957 6.321436437 54859 elongator acetyltransferase complex subunit 6 "GO:0002098,GO:0003674,GO:0005634,GO:0005829,GO:0008150,GO:0030335,GO:0033588" tRNA wobble uridine modification|molecular_function|nucleus|cytosol|biological_process|positive regulation of cell migration|elongator holoenzyme complex EMB 1460.799382 1484.670611 1436.928154 0.967843065 -0.04715496 0.84615872 1 18.23570582 17.35396425 133418 embigin "GO:0005886,GO:0005887,GO:0007156,GO:0007411,GO:0030424,GO:0035879,GO:0045202,GO:0070593,GO:0098632" plasma membrane|integral component of plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|axon guidance|axon|plasma membrane lactate transport|synapse|dendrite self-avoidance|cell-cell adhesion mediator activity EMC1 1214.92271 1337.972253 1091.873166 0.816065627 -0.293242918 0.225437036 1 10.73922696 8.617261754 23065 ER membrane protein complex subunit 1 "GO:0005789,GO:0016021,GO:0030176,GO:0032977,GO:0032991,GO:0045050,GO:0071816,GO:0072546" endoplasmic reticulum membrane|integral component of membrane|integral component of endoplasmic reticulum membrane|membrane insertase activity|protein-containing complex|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|tail-anchored membrane protein insertion into ER membrane|EMC complex EMC10 402.2117419 377.6702394 426.7532445 1.129962597 0.176275018 0.545658119 1 1.888640044 2.098381459 284361 ER membrane protein complex subunit 10 "GO:0001525,GO:0001938,GO:0005576,GO:0010595,GO:0016021,GO:0030176,GO:0032977,GO:0045050,GO:0045766,GO:0071816,GO:0072546,GO:1900745" angiogenesis|positive regulation of endothelial cell proliferation|extracellular region|positive regulation of endothelial cell migration|integral component of membrane|integral component of endoplasmic reticulum membrane|membrane insertase activity|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|positive regulation of angiogenesis|tail-anchored membrane protein insertion into ER membrane|EMC complex|positive regulation of p38MAPK cascade EMC2 1048.764074 937.4129083 1160.115239 1.237571223 0.307511555 0.20920488 1 12.4945065 15.20409197 9694 ER membrane protein complex subunit 2 "GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0032977,GO:0042406,GO:0045050,GO:0071816,GO:0072546" protein binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|membrane insertase activity|extrinsic component of endoplasmic reticulum membrane|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|tail-anchored membrane protein insertion into ER membrane|EMC complex EMC3 921.4115238 836.4927616 1006.330286 1.203035259 0.266678926 0.282173452 1 16.49744319 19.51489308 55831 ER membrane protein complex subunit 3 "GO:0003674,GO:0005515,GO:0016021,GO:0030176,GO:0032977,GO:0045050,GO:0071816,GO:0072546" molecular_function|protein binding|integral component of membrane|integral component of endoplasmic reticulum membrane|membrane insertase activity|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|tail-anchored membrane protein insertion into ER membrane|EMC complex EMC4 966.1744728 863.5435226 1068.805423 1.237697227 0.307658437 0.212373176 1 45.22642853 55.03993215 51234 ER membrane protein complex subunit 4 "GO:0005515,GO:0006915,GO:0016021,GO:0030176,GO:0032977,GO:0045050,GO:0071816,GO:0072546" protein binding|apoptotic process|integral component of membrane|integral component of endoplasmic reticulum membrane|membrane insertase activity|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|tail-anchored membrane protein insertion into ER membrane|EMC complex EMC6 455.37726 423.4484502 487.3060697 1.150803762 0.202641843 0.471351501 1 34.44918525 38.98085913 83460 ER membrane protein complex subunit 6 "GO:0000045,GO:0005515,GO:0016021,GO:0030176,GO:0032977,GO:0045050,GO:0071816,GO:0072546,GO:0097631" autophagosome assembly|protein binding|integral component of membrane|integral component of endoplasmic reticulum membrane|membrane insertase activity|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|tail-anchored membrane protein insertion into ER membrane|EMC complex|integral component of omegasome membrane EMC7 857.8965871 733.4917873 982.301387 1.339212523 0.421384924 0.0914032 1 36.61843647 48.2192529 56851 ER membrane protein complex subunit 7 "GO:0005515,GO:0016021,GO:0030176,GO:0030246,GO:0032977,GO:0045050,GO:0071816,GO:0072546" protein binding|integral component of membrane|integral component of endoplasmic reticulum membrane|carbohydrate binding|membrane insertase activity|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|tail-anchored membrane protein insertion into ER membrane|EMC complex EMC8 768.2021124 700.198543 836.2056817 1.194240819 0.256093786 0.311981589 1 16.15577576 18.97102981 10328 ER membrane protein complex subunit 8 "GO:0005515,GO:0005737,GO:0005829,GO:0016020,GO:0032977,GO:0045050,GO:0071816,GO:0072546" protein binding|cytoplasm|cytosol|membrane|membrane insertase activity|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|tail-anchored membrane protein insertion into ER membrane|EMC complex EMC9 282.8654715 285.0734038 280.6575392 0.984509728 -0.022522634 0.956190074 1 13.39246798 12.96438163 51016 ER membrane protein complex subunit 9 "GO:0005515,GO:0005737,GO:0032977,GO:0045050,GO:0071816,GO:0072546" protein binding|cytoplasm|membrane insertase activity|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|tail-anchored membrane protein insertion into ER membrane|EMC complex EMD 2501.606866 2389.830688 2613.383044 1.093543177 0.129010185 0.585948689 1 95.17975486 102.3414806 2010 emerin "GO:0003779,GO:0005515,GO:0005635,GO:0005637,GO:0005640,GO:0005654,GO:0005737,GO:0005783,GO:0005819,GO:0005874,GO:0006936,GO:0007084,GO:0007517,GO:0016020,GO:0016021,GO:0031616,GO:0031965,GO:0032541,GO:0035914,GO:0045296,GO:0046827,GO:0048147,GO:0048487,GO:0060828,GO:0071363,GO:0071763,GO:0090090" actin binding|protein binding|nuclear envelope|nuclear inner membrane|nuclear outer membrane|nucleoplasm|cytoplasm|endoplasmic reticulum|spindle|microtubule|muscle contraction|mitotic nuclear envelope reassembly|muscle organ development|membrane|integral component of membrane|spindle pole centrosome|nuclear membrane|cortical endoplasmic reticulum|skeletal muscle cell differentiation|cadherin binding|positive regulation of protein export from nucleus|negative regulation of fibroblast proliferation|beta-tubulin binding|regulation of canonical Wnt signaling pathway|cellular response to growth factor stimulus|nuclear membrane organization|negative regulation of canonical Wnt signaling pathway "hsa05410,hsa05412,hsa05414" Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy EME1 663.6688565 718.9259929 608.4117201 0.846278652 -0.240795321 0.352234627 1 20.20419111 16.81225745 146956 essential meiotic structure-specific endonuclease 1 "GO:0000712,GO:0000792,GO:0003677,GO:0004519,GO:0005515,GO:0005654,GO:0005730,GO:0006302,GO:0031297,GO:0031573,GO:0036297,GO:0046872,GO:0048476,GO:0072429,GO:0090305" resolution of meiotic recombination intermediates|heterochromatin|DNA binding|endonuclease activity|protein binding|nucleoplasm|nucleolus|double-strand break repair|replication fork processing|intra-S DNA damage checkpoint|interstrand cross-link repair|metal ion binding|Holliday junction resolvase complex|response to intra-S DNA damage checkpoint signaling|nucleic acid phosphodiester bond hydrolysis "hsa03440,hsa03460" Homologous recombination|Fanconi anemia pathway EME2 15.53198073 16.64662212 14.41733934 0.866081974 -0.207424514 0.893114177 1 0.436774645 0.371952599 197342 essential meiotic structure-specific endonuclease subunit 2 "GO:0000712,GO:0003677,GO:0004519,GO:0005515,GO:0005634,GO:0006302,GO:0031297,GO:0031573,GO:0048476,GO:0090305" resolution of meiotic recombination intermediates|DNA binding|endonuclease activity|protein binding|nucleus|double-strand break repair|replication fork processing|intra-S DNA damage checkpoint|Holliday junction resolvase complex|nucleic acid phosphodiester bond hydrolysis hsa03460 Fanconi anemia pathway EMG1 1125.813837 1143.414857 1108.212817 0.969213239 -0.045113983 0.856325689 1 12.52246038 11.93383922 10436 EMG1 N1-specific pseudouridine methyltransferase "GO:0001824,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0006364,GO:0017126,GO:0019843,GO:0032040,GO:0042274,GO:0042802,GO:0070037,GO:0070475" blastocyst development|RNA binding|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|cytoplasm|rRNA processing|nucleologenesis|rRNA binding|small-subunit processome|ribosomal small subunit biogenesis|identical protein binding|rRNA (pseudouridine) methyltransferase activity|rRNA base methylation hsa03008 Ribosome biogenesis in eukaryotes EMID1 7.486072413 7.282897178 7.689247648 1.055795168 0.078329968 1 1 0.068537266 0.071150446 129080 EMI domain containing 1 "GO:0005576,GO:0005581" extracellular region|collagen trimer EMILIN1 3.522561699 4.161655531 2.883467868 0.692865579 -0.529352609 0.940314863 1 0.057095092 0.038897254 11117 elastin microfibril interfacer 1 "GO:0003180,GO:0005201,GO:0005515,GO:0005576,GO:0005581,GO:0005615,GO:0007155,GO:0007160,GO:0010628,GO:0010629,GO:0010811,GO:0016477,GO:0016525,GO:0030023,GO:0030512,GO:0030948,GO:0032966,GO:0034668,GO:0042802,GO:0048251,GO:0050866,GO:0060394,GO:0062023,GO:0070062,GO:0070373,GO:0098640,GO:1901203,GO:1904027,GO:1905522,GO:1990971" aortic valve morphogenesis|extracellular matrix structural constituent|protein binding|extracellular region|collagen trimer|extracellular space|cell adhesion|cell-matrix adhesion|positive regulation of gene expression|negative regulation of gene expression|positive regulation of cell-substrate adhesion|cell migration|negative regulation of angiogenesis|extracellular matrix constituent conferring elasticity|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of vascular endothelial growth factor receptor signaling pathway|negative regulation of collagen biosynthetic process|integrin alpha4-beta1 complex|identical protein binding|elastic fiber assembly|negative regulation of cell activation|negative regulation of pathway-restricted SMAD protein phosphorylation|collagen-containing extracellular matrix|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|integrin binding involved in cell-matrix adhesion|positive regulation of extracellular matrix assembly|negative regulation of collagen fibril organization|negative regulation of macrophage migration|EMILIN complex EMILIN2 48.60254245 39.53572754 57.66935736 1.458664376 0.544647972 0.376682131 1 0.341139711 0.489281543 84034 elastin microfibril interfacer 2 "GO:0005515,GO:0005576,GO:0005581,GO:0007155,GO:0008150,GO:0030023,GO:0062023" protein binding|extracellular region|collagen trimer|cell adhesion|biological_process|extracellular matrix constituent conferring elasticity|collagen-containing extracellular matrix EML1 10.68657199 15.60620824 5.766935736 0.369528309 -1.436243205 0.20707843 1 0.159676889 0.05801776 2009 EMAP like 1 "GO:0000226,GO:0005509,GO:0005515,GO:0005829,GO:0005874,GO:0005875,GO:0007052,GO:0007405,GO:0007420,GO:0008017,GO:0015630,GO:0015631,GO:0048471,GO:0072686,GO:0097431,GO:1990023" microtubule cytoskeleton organization|calcium ion binding|protein binding|cytosol|microtubule|microtubule associated complex|mitotic spindle organization|neuroblast proliferation|brain development|microtubule binding|microtubule cytoskeleton|tubulin binding|perinuclear region of cytoplasm|mitotic spindle|mitotic spindle pole|mitotic spindle midzone EML2 1355.460299 1217.284243 1493.636356 1.227023487 0.295162864 0.218870428 1 16.74767279 20.20591499 24139 EMAP like 2 "GO:0000226,GO:0005102,GO:0005515,GO:0005737,GO:0005874,GO:0005875,GO:0007601,GO:0007605,GO:0008017,GO:0008022,GO:0010968,GO:0015631,GO:0031115,GO:0072686" microtubule cytoskeleton organization|signaling receptor binding|protein binding|cytoplasm|microtubule|microtubule associated complex|visual perception|sensory perception of sound|microtubule binding|protein C-terminus binding|regulation of microtubule nucleation|tubulin binding|negative regulation of microtubule polymerization|mitotic spindle EML3 952.2817565 953.0191165 951.5443964 0.998452581 -0.002234183 0.997663995 1 15.71235053 15.42551889 256364 EMAP like 3 "GO:0000226,GO:0005515,GO:0005634,GO:0005737,GO:0005819,GO:0005876,GO:0007080,GO:0008017,GO:0015630,GO:0030496,GO:0072686,GO:1901673,GO:1990498" microtubule cytoskeleton organization|protein binding|nucleus|cytoplasm|spindle|spindle microtubule|mitotic metaphase plate congression|microtubule binding|microtubule cytoskeleton|midbody|mitotic spindle|regulation of mitotic spindle assembly|mitotic spindle microtubule EML4 1649.238827 1751.016564 1547.461089 0.883750114 -0.178289598 0.453851169 1 16.02341149 13.92373174 27436 EMAP like 4 "GO:0000226,GO:0000278,GO:0003674,GO:0005515,GO:0005737,GO:0005815,GO:0005874,GO:0007017,GO:0007080,GO:0008017,GO:0008608,GO:0016020,GO:0030496,GO:0043014,GO:0048487,GO:0072686" microtubule cytoskeleton organization|mitotic cell cycle|molecular_function|protein binding|cytoplasm|microtubule organizing center|microtubule|microtubule-based process|mitotic metaphase plate congression|microtubule binding|attachment of spindle microtubules to kinetochore|membrane|midbody|alpha-tubulin binding|beta-tubulin binding|mitotic spindle "hsa05200,hsa05223,hsa05235" Pathways in cancer|Non-small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer EML5 6.965865472 6.242483296 7.689247648 1.231761029 0.300722389 0.937576592 1 0.02770477 0.033554609 161436 EMAP like 5 "GO:0003674,GO:0003824,GO:0005737,GO:0005874,GO:0008017,GO:0008150,GO:0070062" molecular_function|catalytic activity|cytoplasm|microtubule|microtubule binding|biological_process|extracellular exosome EML6 83.02048892 97.79890497 68.24207288 0.697779519 -0.519156842 0.301468004 1 0.521205094 0.357600443 400954 EMAP like 6 "GO:0005737,GO:0005874,GO:0008017" cytoplasm|microtubule|microtubule binding EMP1 8136.258706 8266.088298 8006.429113 0.968587417 -0.046045834 0.852509971 1 154.7337566 147.3652451 2012 epithelial membrane protein 1 "GO:0005515,GO:0005886,GO:0008219,GO:0008544,GO:0016021,GO:0032060" protein binding|plasma membrane|cell death|epidermis development|integral component of membrane|bleb assembly EMP2 230.6711703 214.3252598 247.0170807 1.152533681 0.204808912 0.558610254 1 2.174965812 2.464774766 2013 epithelial membrane protein 2 "GO:0000139,GO:0001765,GO:0001913,GO:0001952,GO:0001954,GO:0003093,GO:0005178,GO:0005515,GO:0005634,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0005901,GO:0007015,GO:0007155,GO:0007160,GO:0007566,GO:0008219,GO:0008283,GO:0008284,GO:0009986,GO:0010594,GO:0016021,GO:0016324,GO:0016477,GO:0019900,GO:0019901,GO:0031410,GO:0032060,GO:0032147,GO:0034394,GO:0043534,GO:0043549,GO:0045022,GO:0045121,GO:0045177,GO:0045765,GO:0070252,GO:0070836,GO:0072659,GO:2001046,GO:2001212" Golgi membrane|membrane raft assembly|T cell mediated cytotoxicity|regulation of cell-matrix adhesion|positive regulation of cell-matrix adhesion|regulation of glomerular filtration|integrin binding|protein binding|nucleus|cytoplasm|Golgi apparatus|cytosol|plasma membrane|caveola|actin filament organization|cell adhesion|cell-matrix adhesion|embryo implantation|cell death|cell population proliferation|positive regulation of cell population proliferation|cell surface|regulation of endothelial cell migration|integral component of membrane|apical plasma membrane|cell migration|kinase binding|protein kinase binding|cytoplasmic vesicle|bleb assembly|activation of protein kinase activity|protein localization to cell surface|blood vessel endothelial cell migration|regulation of kinase activity|early endosome to late endosome transport|membrane raft|apical part of cell|regulation of angiogenesis|actin-mediated cell contraction|caveola assembly|protein localization to plasma membrane|positive regulation of integrin-mediated signaling pathway|regulation of vasculogenesis EMP3 1305.262537 1161.101893 1449.423182 1.248316957 0.319984292 0.18361429 1 81.53404476 100.0771746 2014 epithelial membrane protein 3 "GO:0005515,GO:0005886,GO:0008219,GO:0016021,GO:0032060" protein binding|plasma membrane|cell death|integral component of membrane|bleb assembly EMSY 1038.562496 1010.24188 1066.883111 1.056067 0.078701366 0.751066625 1 7.452965495 7.739123213 56946 "EMSY transcriptional repressor, BRCA2 interacting" "GO:0005515,GO:0005654,GO:0006281,GO:0006325,GO:0006355,GO:0042802" "protein binding|nucleoplasm|DNA repair|chromatin organization|regulation of transcription, DNA-templated|identical protein binding" EN1 139.832486 138.3750464 141.2899255 1.021065064 0.030074799 0.961373997 1 3.042777875 3.054884853 2019 engrailed homeobox 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001501,GO:0005634,GO:0006357,GO:0008344,GO:0009653,GO:0009953,GO:0009954,GO:0016020,GO:0021549,GO:0030182,GO:0030901,GO:0030917,GO:0035115,GO:0035176,GO:0035264,GO:0042220,GO:0042756,GO:0043473,GO:0043524,GO:0045944,GO:0048666,GO:0061743,GO:0071542,GO:1990403,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|skeletal system development|nucleus|regulation of transcription by RNA polymerase II|adult locomotory behavior|anatomical structure morphogenesis|dorsal/ventral pattern formation|proximal/distal pattern formation|membrane|cerebellum development|neuron differentiation|midbrain development|midbrain-hindbrain boundary development|embryonic forelimb morphogenesis|social behavior|multicellular organism growth|response to cocaine|drinking behavior|pigmentation|negative regulation of neuron apoptotic process|positive regulation of transcription by RNA polymerase II|neuron development|motor learning|dopaminergic neuron differentiation|embryonic brain development|sequence-specific double-stranded DNA binding" ENAH 2031.918636 2398.153999 1665.683272 0.694568936 -0.525810206 0.02639125 0.869639386 8.443400932 5.766389135 55740 ENAH actin regulator "GO:0003779,GO:0005515,GO:0005522,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0007411,GO:0008154,GO:0017124,GO:0030027,GO:0030054,GO:0030175,GO:0045202,GO:0050699,GO:0070358" actin binding|protein binding|profilin binding|cytosol|cytoskeleton|plasma membrane|focal adhesion|axon guidance|actin polymerization or depolymerization|SH3 domain binding|lamellipodium|cell junction|filopodium|synapse|WW domain binding|actin polymerization-dependent cell motility "hsa04015,hsa04360,hsa04810" Rap1 signaling pathway|Axon guidance|Regulation of actin cytoskeleton ENAM 4.003139677 4.161655531 3.844623824 0.923820772 -0.11431511 1 1 0.029585708 0.026874529 10117 enamelin "GO:0005515,GO:0005788,GO:0030345,GO:0031012,GO:0031214,GO:0036305,GO:0043687,GO:0044267,GO:0070175,GO:0097186" protein binding|endoplasmic reticulum lumen|structural constituent of tooth enamel|extracellular matrix|biomineral tissue development|ameloblast differentiation|post-translational protein modification|cellular protein metabolic process|positive regulation of enamel mineralization|amelogenesis ENC1 1677.519929 1534.610477 1820.429381 1.186248503 0.246406266 0.299883447 1 16.28541274 18.99527677 8507 ectodermal-neural cortex 1 "GO:0003779,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005856,GO:0007275,GO:0007399,GO:0010499,GO:0010976,GO:0016363,GO:0016567,GO:0017148,GO:0031463,GO:0043025" actin binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytoskeleton|multicellular organism development|nervous system development|proteasomal ubiquitin-independent protein catabolic process|positive regulation of neuron projection development|nuclear matrix|protein ubiquitination|negative regulation of translation|Cul3-RING ubiquitin ligase complex|neuronal cell body ENDOD1 1091.009662 1049.777608 1132.241716 1.078553884 0.109098255 0.657064727 1 12.04573242 12.77456845 23052 endonuclease domain containing 1 "GO:0002576,GO:0003676,GO:0004519,GO:0005515,GO:0005576,GO:0005829,GO:0016020,GO:0046872,GO:0070062,GO:0090305" platelet degranulation|nucleic acid binding|endonuclease activity|protein binding|extracellular region|cytosol|membrane|metal ion binding|extracellular exosome|nucleic acid phosphodiester bond hydrolysis ENDOG 180.1066869 173.7491184 186.4642555 1.073181016 0.10189344 0.800473017 1 6.768373074 7.142141488 2021 endonuclease G "GO:0000014,GO:0001701,GO:0003676,GO:0004519,GO:0004521,GO:0005515,GO:0005634,GO:0005743,GO:0005829,GO:0006309,GO:0006310,GO:0007568,GO:0009612,GO:0032355,GO:0034612,GO:0036475,GO:0043065,GO:0043204,GO:0046677,GO:0046872,GO:0071277,GO:0071333,GO:0071456,GO:0090502,GO:1901300,GO:1902512" "single-stranded DNA endodeoxyribonuclease activity|in utero embryonic development|nucleic acid binding|endonuclease activity|endoribonuclease activity|protein binding|nucleus|mitochondrial inner membrane|cytosol|apoptotic DNA fragmentation|DNA recombination|aging|response to mechanical stimulus|response to estradiol|response to tumor necrosis factor|neuron death in response to oxidative stress|positive regulation of apoptotic process|perikaryon|response to antibiotic|metal ion binding|cellular response to calcium ion|cellular response to glucose stimulus|cellular response to hypoxia|RNA phosphodiester bond hydrolysis, endonucleolytic|positive regulation of hydrogen peroxide-mediated programmed cell death|positive regulation of apoptotic DNA fragmentation" hsa04210 Apoptosis ENDOV 169.7025481 152.9408407 186.4642555 1.219192039 0.285925387 0.465595622 1 1.704002417 2.042741929 284131 endonuclease V "GO:0000287,GO:0003677,GO:0003727,GO:0005515,GO:0005730,GO:0005737,GO:0006281,GO:0010494,GO:0016888,GO:0016891,GO:0090502" "magnesium ion binding|DNA binding|single-stranded RNA binding|protein binding|nucleolus|cytoplasm|DNA repair|cytoplasmic stress granule|endodeoxyribonuclease activity, producing 5'-phosphomonoesters|endoribonuclease activity, producing 5'-phosphomonoesters|RNA phosphodiester bond hydrolysis, endonucleolytic" ENG 1501.449751 1580.388688 1422.510815 0.900101871 -0.151839804 0.525586663 1 25.7220005 22.76499637 2022 endoglin "GO:0001525,GO:0001569,GO:0001570,GO:0001837,GO:0001934,GO:0001947,GO:0002040,GO:0003148,GO:0003198,GO:0003203,GO:0003208,GO:0003209,GO:0003222,GO:0003273,GO:0004888,GO:0005024,GO:0005114,GO:0005515,GO:0005534,GO:0005539,GO:0005615,GO:0005886,GO:0005925,GO:0006355,GO:0007155,GO:0007179,GO:0009897,GO:0009986,GO:0010629,GO:0010665,GO:0010862,GO:0015026,GO:0016021,GO:0016477,GO:0016604,GO:0017015,GO:0022009,GO:0030336,GO:0030509,GO:0030513,GO:0031953,GO:0031960,GO:0032967,GO:0034713,GO:0035912,GO:0036122,GO:0042493,GO:0042802,GO:0042803,GO:0043235,GO:0045766,GO:0045944,GO:0048185,GO:0048745,GO:0048844,GO:0048845,GO:0050431,GO:0051897,GO:0055009,GO:0060348,GO:0070278,GO:0071260,GO:0072563,GO:0090500,GO:0097084,GO:1905007,GO:1905065,GO:1905222,GO:1905310,GO:2000136" "angiogenesis|branching involved in blood vessel morphogenesis|vasculogenesis|epithelial to mesenchymal transition|positive regulation of protein phosphorylation|heart looping|sprouting angiogenesis|outflow tract septum morphogenesis|epithelial to mesenchymal transition involved in endocardial cushion formation|endocardial cushion morphogenesis|cardiac ventricle morphogenesis|cardiac atrium morphogenesis|ventricular trabecula myocardium morphogenesis|cell migration involved in endocardial cushion formation|transmembrane signaling receptor activity|transforming growth factor beta-activated receptor activity|type II transforming growth factor beta receptor binding|protein binding|galactose binding|glycosaminoglycan binding|extracellular space|plasma membrane|focal adhesion|regulation of transcription, DNA-templated|cell adhesion|transforming growth factor beta receptor signaling pathway|external side of plasma membrane|cell surface|negative regulation of gene expression|regulation of cardiac muscle cell apoptotic process|positive regulation of pathway-restricted SMAD protein phosphorylation|coreceptor activity|integral component of membrane|cell migration|nuclear body|regulation of transforming growth factor beta receptor signaling pathway|central nervous system vasculogenesis|negative regulation of cell migration|BMP signaling pathway|positive regulation of BMP signaling pathway|negative regulation of protein autophosphorylation|response to corticosteroid|positive regulation of collagen biosynthetic process|type I transforming growth factor beta receptor binding|dorsal aorta morphogenesis|BMP binding|response to drug|identical protein binding|protein homodimerization activity|receptor complex|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|activin binding|smooth muscle tissue development|artery morphogenesis|venous blood vessel morphogenesis|transforming growth factor beta binding|positive regulation of protein kinase B signaling|atrial cardiac muscle tissue morphogenesis|bone development|extracellular matrix constituent secretion|cellular response to mechanical stimulus|endothelial microparticle|endocardial cushion to mesenchymal transition|vascular associated smooth muscle cell development|positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|positive regulation of vascular associated smooth muscle cell differentiation|atrioventricular canal morphogenesis|regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis|regulation of cell proliferation involved in heart morphogenesis" ENGASE 624.1626971 665.8648849 582.4605093 0.874742793 -0.193069221 0.461495369 1 6.775211649 5.827394481 64772 endo-beta-N-acetylglucosaminidase "GO:0004553,GO:0005829,GO:0006457,GO:0006517,GO:0033925" "hydrolase activity, hydrolyzing O-glycosyl compounds|cytosol|protein folding|protein deglycosylation|mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity" hsa00511 Other glycan degradation ENKD1 387.2295363 388.0743782 386.3846943 0.995645979 -0.006295239 0.992891977 1 9.409730266 9.211986592 84080 enkurin domain containing 1 "GO:0005515,GO:0005881,GO:0015630,GO:0097546" protein binding|cytoplasmic microtubule|microtubule cytoskeleton|ciliary base ENKUR 43.79676267 39.53572754 48.0577978 1.215553647 0.281613566 0.678897468 1 0.557892415 0.666800269 219670 "enkurin, TRPC channel interacting protein" "GO:0001669,GO:0005515,GO:0005516,GO:0017124,GO:0030317,GO:0061966,GO:0097228,GO:0097728,GO:0097729" acrosomal vesicle|protein binding|calmodulin binding|SH3 domain binding|flagellated sperm motility|establishment of left/right asymmetry|sperm principal piece|9+0 motile cilium|9+2 motile cilium ENO1 43540.67179 39095.63247 47985.7111 1.22739314 0.295597426 0.35017634 1 660.0639197 796.6010314 2023 enolase 1 "GO:0000015,GO:0000122,GO:0000287,GO:0000977,GO:0001227,GO:0003723,GO:0004634,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006094,GO:0006096,GO:0009615,GO:0009986,GO:0010756,GO:0016020,GO:0030308,GO:0031430,GO:0032889,GO:0042803,GO:0045296,GO:0045892,GO:0045933,GO:0051020,GO:0061621,GO:0070062,GO:0099738,GO:1903298,GO:2001171" "phosphopyruvate hydratase complex|negative regulation of transcription by RNA polymerase II|magnesium ion binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|RNA binding|phosphopyruvate hydratase activity|protein binding|extracellular space|nucleus|cytoplasm|cytosol|plasma membrane|gluconeogenesis|glycolytic process|response to virus|cell surface|positive regulation of plasminogen activation|membrane|negative regulation of cell growth|M band|regulation of vacuole fusion, non-autophagic|protein homodimerization activity|cadherin binding|negative regulation of transcription, DNA-templated|positive regulation of muscle contraction|GTPase binding|canonical glycolysis|extracellular exosome|cell cortex region|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway|positive regulation of ATP biosynthetic process" "hsa00010,hsa03018,hsa04066" Glycolysis / Gluconeogenesis|RNA degradation|HIF-1 signaling pathway ENO2 3188.937171 2430.40683 3947.467511 1.624200304 0.699729563 0.003255503 0.367925679 56.54156304 90.29809245 2026 enolase 2 "GO:0000015,GO:0000287,GO:0001917,GO:0004634,GO:0005515,GO:0005615,GO:0005829,GO:0005886,GO:0006094,GO:0006096,GO:0016020,GO:0032889,GO:0043204,GO:0061621,GO:0070062" "phosphopyruvate hydratase complex|magnesium ion binding|photoreceptor inner segment|phosphopyruvate hydratase activity|protein binding|extracellular space|cytosol|plasma membrane|gluconeogenesis|glycolytic process|membrane|regulation of vacuole fusion, non-autophagic|perikaryon|canonical glycolysis|extracellular exosome" "hsa00010,hsa03018,hsa04066" Glycolysis / Gluconeogenesis|RNA degradation|HIF-1 signaling pathway ENO3 74.9745806 88.43518002 61.51398118 0.695582699 -0.523706046 0.315316616 1 2.870816923 1.963475323 2027 enolase 3 "GO:0000015,GO:0000287,GO:0004634,GO:0005615,GO:0005829,GO:0005886,GO:0006094,GO:0006096,GO:0007568,GO:0016020,GO:0032889,GO:0042493,GO:0042802,GO:0043403,GO:0044877,GO:0061621,GO:0070062" "phosphopyruvate hydratase complex|magnesium ion binding|phosphopyruvate hydratase activity|extracellular space|cytosol|plasma membrane|gluconeogenesis|glycolytic process|aging|membrane|regulation of vacuole fusion, non-autophagic|response to drug|identical protein binding|skeletal muscle tissue regeneration|protein-containing complex binding|canonical glycolysis|extracellular exosome" "hsa00010,hsa03018,hsa04066" Glycolysis / Gluconeogenesis|RNA degradation|HIF-1 signaling pathway ENOPH1 950.0474433 932.2108388 967.8840477 1.038267318 0.054177936 0.830225017 1 24.22121672 24.72727837 58478 enolase-phosphatase 1 "GO:0000287,GO:0005515,GO:0005634,GO:0005829,GO:0016311,GO:0019284,GO:0019509,GO:0043715,GO:0043716,GO:0043874" "magnesium ion binding|protein binding|nucleus|cytosol|dephosphorylation|L-methionine salvage from S-adenosylmethionine|L-methionine salvage from methylthioadenosine|2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity|2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity|acireductone synthase activity" hsa00270 Cysteine and methionine metabolism ENOSF1 766.3880121 829.2098645 703.5661598 0.848477798 -0.237051186 0.349540086 1 7.653650371 6.385284913 55556 enolase superfamily member 1 "GO:0000287,GO:0005575,GO:0005739,GO:0009063,GO:0016052,GO:0016836,GO:0016853,GO:0044275,GO:0050023" magnesium ion binding|cellular_component|mitochondrion|cellular amino acid catabolic process|carbohydrate catabolic process|hydro-lyase activity|isomerase activity|cellular carbohydrate catabolic process|L-fuconate dehydratase activity hsa00051 Fructose and mannose metabolism ENOX1 42.31036935 50.98028025 33.64045846 0.65987198 -0.599741937 0.353361951 1 0.199979703 0.129752814 55068 ecto-NOX disulfide-thiol exchanger 1 "GO:0003676,GO:0005515,GO:0005615,GO:0005886,GO:0007624,GO:0009897,GO:0016491,GO:0055114" nucleic acid binding|protein binding|extracellular space|plasma membrane|ultradian rhythm|external side of plasma membrane|oxidoreductase activity|oxidation-reduction process ENOX2 293.626271 315.2454064 272.0071355 0.862842503 -0.212830851 0.505855854 1 2.972975428 2.522284251 10495 ecto-NOX disulfide-thiol exchanger 2 "GO:0003676,GO:0005615,GO:0005829,GO:0007624,GO:0009897,GO:0015035,GO:0040008,GO:0055114" nucleic acid binding|extracellular space|cytosol|ultradian rhythm|external side of plasma membrane|protein disulfide oxidoreductase activity|regulation of growth|oxidation-reduction process ENPEP 4.964295633 4.161655531 5.766935736 1.385731158 0.470647391 0.897151737 1 0.046738196 0.063682793 2028 glutamyl aminopeptidase "GO:0001525,GO:0002003,GO:0003081,GO:0004177,GO:0005737,GO:0005765,GO:0005886,GO:0005887,GO:0005903,GO:0006508,GO:0007165,GO:0007267,GO:0008217,GO:0008270,GO:0008283,GO:0009897,GO:0016324,GO:0016477,GO:0031410,GO:0032835,GO:0042277,GO:0043171,GO:0045177,GO:0070006,GO:0070062" angiogenesis|angiotensin maturation|regulation of systemic arterial blood pressure by renin-angiotensin|aminopeptidase activity|cytoplasm|lysosomal membrane|plasma membrane|integral component of plasma membrane|brush border|proteolysis|signal transduction|cell-cell signaling|regulation of blood pressure|zinc ion binding|cell population proliferation|external side of plasma membrane|apical plasma membrane|cell migration|cytoplasmic vesicle|glomerulus development|peptide binding|peptide catabolic process|apical part of cell|metalloaminopeptidase activity|extracellular exosome hsa04614 Renin-angiotensin system ENPP1 376.8549656 393.2764476 360.4334835 0.916488861 -0.125810749 0.674702648 1 2.821785587 2.542859591 5167 ectonucleotide pyrophosphatase/phosphodiesterase 1 "GO:0003676,GO:0004527,GO:0004528,GO:0004551,GO:0005044,GO:0005158,GO:0005509,GO:0005515,GO:0005524,GO:0005615,GO:0005765,GO:0005886,GO:0005887,GO:0006091,GO:0006771,GO:0006796,GO:0006897,GO:0006955,GO:0008270,GO:0009143,GO:0009986,GO:0016021,GO:0016323,GO:0030247,GO:0030308,GO:0030318,GO:0030500,GO:0030502,GO:0030505,GO:0030643,GO:0030730,GO:0031214,GO:0031953,GO:0032869,GO:0035529,GO:0036218,GO:0042803,GO:0045599,GO:0045719,GO:0046034,GO:0046325,GO:0046627,GO:0047429,GO:0050427,GO:0050656,GO:0090305,GO:0106177,GO:1990787" nucleic acid binding|exonuclease activity|phosphodiesterase I activity|nucleotide diphosphatase activity|scavenger receptor activity|insulin receptor binding|calcium ion binding|protein binding|ATP binding|extracellular space|lysosomal membrane|plasma membrane|integral component of plasma membrane|generation of precursor metabolites and energy|riboflavin metabolic process|phosphate-containing compound metabolic process|endocytosis|immune response|zinc ion binding|nucleoside triphosphate catabolic process|cell surface|integral component of membrane|basolateral plasma membrane|polysaccharide binding|negative regulation of cell growth|melanocyte differentiation|regulation of bone mineralization|negative regulation of bone mineralization|inorganic diphosphate transport|cellular phosphate ion homeostasis|sequestering of triglyceride|biomineral tissue development|negative regulation of protein autophosphorylation|cellular response to insulin stimulus|NADH pyrophosphatase activity|dTTP diphosphatase activity|protein homodimerization activity|negative regulation of fat cell differentiation|negative regulation of glycogen biosynthetic process|ATP metabolic process|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|nucleoside-triphosphate diphosphatase activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process|3'-phosphoadenosine 5'-phosphosulfate binding|nucleic acid phosphodiester bond hydrolysis|cyclic-GMP-AMP hydrolase activity|negative regulation of hh target transcription factor activity "hsa00230,hsa00240,hsa00500,hsa00740,hsa00760,hsa00770" Purine metabolism|Pyrimidine metabolism|Starch and sucrose metabolism|Riboflavin metabolism|Nicotinate and nicotinamide metabolism|Pantothenate and CoA biosynthesis ENPP2 78.26439894 73.86938567 82.65941222 1.118994174 0.162202525 0.771027708 1 1.140374124 1.254718664 5168 ectonucleotide pyrophosphatase/phosphodiesterase 2 "GO:0003676,GO:0004528,GO:0004551,GO:0004622,GO:0005044,GO:0005509,GO:0005615,GO:0005886,GO:0006897,GO:0006935,GO:0006955,GO:0008134,GO:0008270,GO:0009395,GO:0010634,GO:0016787,GO:0030149,GO:0030247,GO:0030334,GO:0034638,GO:0045765,GO:0047391,GO:0048870,GO:0050731,GO:0090305,GO:2000394" nucleic acid binding|phosphodiesterase I activity|nucleotide diphosphatase activity|lysophospholipase activity|scavenger receptor activity|calcium ion binding|extracellular space|plasma membrane|endocytosis|chemotaxis|immune response|transcription factor binding|zinc ion binding|phospholipid catabolic process|positive regulation of epithelial cell migration|hydrolase activity|sphingolipid catabolic process|polysaccharide binding|regulation of cell migration|phosphatidylcholine catabolic process|regulation of angiogenesis|alkylglycerophosphoethanolamine phosphodiesterase activity|cell motility|positive regulation of peptidyl-tyrosine phosphorylation|nucleic acid phosphodiester bond hydrolysis|positive regulation of lamellipodium morphogenesis hsa00565 Ether lipid metabolism ENPP3 5.325986721 1.040413883 9.61155956 9.238207717 3.207612985 0.087285241 1 0.015254114 0.138562561 5169 ectonucleotide pyrophosphatase/phosphodiesterase 3 "GO:0002276,GO:0003676,GO:0004528,GO:0005509,GO:0006220,GO:0006796,GO:0008270,GO:0009143,GO:0009897,GO:0016021,GO:0016324,GO:0030505,GO:0033007,GO:0035529,GO:0036218,GO:0046034,GO:0047429,GO:0048471,GO:0050728,GO:0070062,GO:0070667,GO:0090305" basophil activation involved in immune response|nucleic acid binding|phosphodiesterase I activity|calcium ion binding|pyrimidine nucleotide metabolic process|phosphate-containing compound metabolic process|zinc ion binding|nucleoside triphosphate catabolic process|external side of plasma membrane|integral component of membrane|apical plasma membrane|inorganic diphosphate transport|negative regulation of mast cell activation involved in immune response|NADH pyrophosphatase activity|dTTP diphosphatase activity|ATP metabolic process|nucleoside-triphosphate diphosphatase activity|perinuclear region of cytoplasm|negative regulation of inflammatory response|extracellular exosome|negative regulation of mast cell proliferation|nucleic acid phosphodiester bond hydrolysis "hsa00230,hsa00240,hsa00500,hsa00740,hsa00760,hsa00770" Purine metabolism|Pyrimidine metabolism|Starch and sucrose metabolism|Riboflavin metabolism|Nicotinate and nicotinamide metabolism|Pantothenate and CoA biosynthesis ENPP4 80.37982525 91.55642167 69.20322883 0.755853359 -0.403821727 0.430990094 1 1.052152875 0.781965463 22875 ectonucleotide pyrophosphatase/phosphodiesterase 4 "GO:0005515,GO:0005886,GO:0007596,GO:0016020,GO:0016021,GO:0030194,GO:0043312,GO:0046130,GO:0046872,GO:0047710,GO:0070062,GO:0101003" protein binding|plasma membrane|blood coagulation|membrane|integral component of membrane|positive regulation of blood coagulation|neutrophil degranulation|purine ribonucleoside catabolic process|metal ion binding|bis(5'-adenosyl)-triphosphatase activity|extracellular exosome|ficolin-1-rich granule membrane hsa00230 Purine metabolism ENSA 2608.948134 2558.377737 2659.51853 1.039533174 0.055935799 0.814318545 1 27.20923032 27.81158811 2029 endosulfine alpha "GO:0000086,GO:0000278,GO:0004864,GO:0005102,GO:0005515,GO:0005654,GO:0005737,GO:0007584,GO:0008200,GO:0019212,GO:0019870,GO:0019888,GO:0032515,GO:0035308,GO:0050796,GO:0051301,GO:0051721" G2/M transition of mitotic cell cycle|mitotic cell cycle|protein phosphatase inhibitor activity|signaling receptor binding|protein binding|nucleoplasm|cytoplasm|response to nutrient|ion channel inhibitor activity|phosphatase inhibitor activity|potassium channel inhibitor activity|protein phosphatase regulator activity|negative regulation of phosphoprotein phosphatase activity|negative regulation of protein dephosphorylation|regulation of insulin secretion|cell division|protein phosphatase 2A binding ENTPD1 2.561405743 4.161655531 0.961155956 0.230955193 -2.11431511 0.482263142 1 0.013616572 0.003092194 953 ectonucleoside triphosphate diphosphohydrolase 1 "GO:0004382,GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0007155,GO:0007596,GO:0009134,GO:0016020,GO:0017110,GO:0034656,GO:0045134,GO:0070062,GO:0102485,GO:0102486,GO:0102487,GO:0102488,GO:0102489,GO:0102490,GO:0102491" guanosine-diphosphatase activity|protein binding|ATP binding|plasma membrane|integral component of plasma membrane|cell adhesion|blood coagulation|nucleoside diphosphate catabolic process|membrane|nucleoside-diphosphatase activity|nucleobase-containing small molecule catabolic process|uridine-diphosphatase activity|extracellular exosome|dATP phosphohydrolase activity|dCTP phosphohydrolase activity|dUTP phosphohydrolase activity|dTTP phosphohydrolase activity|GTP phosphohydrolase activity|8-oxo-dGTP phosphohydrolase activity|dGTP phosphohydrolase activity "hsa00230,hsa00240,hsa05169" Purine metabolism|Pyrimidine metabolism|Epstein-Barr virus infection ENTPD2 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.079892053 0.096761194 954 ectonucleoside triphosphate diphosphohydrolase 2 "GO:0004382,GO:0005515,GO:0005524,GO:0005604,GO:0005789,GO:0005886,GO:0007186,GO:0009134,GO:0009181,GO:0016020,GO:0016021,GO:0017110,GO:0017111,GO:0030168,GO:0034656,GO:0045134,GO:0070062" guanosine-diphosphatase activity|protein binding|ATP binding|basement membrane|endoplasmic reticulum membrane|plasma membrane|G protein-coupled receptor signaling pathway|nucleoside diphosphate catabolic process|purine ribonucleoside diphosphate catabolic process|membrane|integral component of membrane|nucleoside-diphosphatase activity|nucleoside-triphosphatase activity|platelet activation|nucleobase-containing small molecule catabolic process|uridine-diphosphatase activity|extracellular exosome "hsa00230,hsa04742" Purine metabolism|Taste transduction ENTPD3 19.13380036 22.88910542 15.3784953 0.671869652 -0.573746729 0.533118397 1 0.226758769 0.149802925 956 ectonucleoside triphosphate diphosphohydrolase 3 "GO:0004382,GO:0005515,GO:0005524,GO:0005886,GO:0009134,GO:0009143,GO:0016020,GO:0016021,GO:0017110,GO:0017111,GO:0034656,GO:0045134,GO:0102485,GO:0102486,GO:0102487,GO:0102488,GO:0102489,GO:0102490,GO:0102491" guanosine-diphosphatase activity|protein binding|ATP binding|plasma membrane|nucleoside diphosphate catabolic process|nucleoside triphosphate catabolic process|membrane|integral component of membrane|nucleoside-diphosphatase activity|nucleoside-triphosphatase activity|nucleobase-containing small molecule catabolic process|uridine-diphosphatase activity|dATP phosphohydrolase activity|dCTP phosphohydrolase activity|dUTP phosphohydrolase activity|dTTP phosphohydrolase activity|GTP phosphohydrolase activity|8-oxo-dGTP phosphohydrolase activity|dGTP phosphohydrolase activity "hsa00230,hsa00240,hsa05169" Purine metabolism|Pyrimidine metabolism|Epstein-Barr virus infection ENTPD4 2030.646093 2276.425575 1784.86661 0.784065436 -0.350954033 0.137953128 1 20.9354901 16.14011482 9583 ectonucleoside triphosphate diphosphohydrolase 4 "GO:0000139,GO:0004382,GO:0005794,GO:0006256,GO:0009134,GO:0016020,GO:0017110,GO:0017111,GO:0030173,GO:0031410,GO:0034656,GO:0036384,GO:0043273,GO:0045134,GO:0046036,GO:0046712,GO:0097637" Golgi membrane|guanosine-diphosphatase activity|Golgi apparatus|UDP catabolic process|nucleoside diphosphate catabolic process|membrane|nucleoside-diphosphatase activity|nucleoside-triphosphatase activity|integral component of Golgi membrane|cytoplasmic vesicle|nucleobase-containing small molecule catabolic process|cytidine-diphosphatase activity|CTPase activity|uridine-diphosphatase activity|CTP metabolic process|GDP catabolic process|integral component of autophagosome membrane "hsa00230,hsa00240,hsa04142" Purine metabolism|Pyrimidine metabolism|Lysosome ENTPD5 526.2883359 657.5415738 395.0350979 0.60077585 -0.735101274 0.006573446 0.483289646 3.8456751 2.2717275 957 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) "GO:0004382,GO:0005515,GO:0005576,GO:0005783,GO:0006487,GO:0009134,GO:0014066,GO:0016020,GO:0017110,GO:0034656,GO:0045134,GO:0045821,GO:0046034,GO:0051084" guanosine-diphosphatase activity|protein binding|extracellular region|endoplasmic reticulum|protein N-linked glycosylation|nucleoside diphosphate catabolic process|regulation of phosphatidylinositol 3-kinase signaling|membrane|nucleoside-diphosphatase activity|nucleobase-containing small molecule catabolic process|uridine-diphosphatase activity|positive regulation of glycolytic process|ATP metabolic process|'de novo' posttranslational protein folding "hsa00230,hsa00240" Purine metabolism|Pyrimidine metabolism ENTPD6 1647.554903 1656.338901 1638.770905 0.989393477 -0.015383707 0.951146045 1 20.18168104 19.63349244 955 ectonucleoside triphosphate diphosphohydrolase 6 "GO:0000139,GO:0004382,GO:0005576,GO:0005615,GO:0005794,GO:0005886,GO:0008894,GO:0009134,GO:0009986,GO:0016020,GO:0016021,GO:0016311,GO:0017110,GO:0017111,GO:0032026,GO:0034656,GO:0036384,GO:0045134,GO:0051592,GO:1990003" "Golgi membrane|guanosine-diphosphatase activity|extracellular region|extracellular space|Golgi apparatus|plasma membrane|guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity|nucleoside diphosphate catabolic process|cell surface|membrane|integral component of membrane|dephosphorylation|nucleoside-diphosphatase activity|nucleoside-triphosphatase activity|response to magnesium ion|nucleobase-containing small molecule catabolic process|cytidine-diphosphatase activity|uridine-diphosphatase activity|response to calcium ion|inosine-diphosphatase activity" "hsa00230,hsa00240" Purine metabolism|Pyrimidine metabolism ENTPD7 1433.054193 1563.742066 1302.36632 0.832852392 -0.263867268 0.270095867 1 9.451193659 7.739731206 57089 ectonucleoside triphosphate diphosphohydrolase 7 "GO:0003924,GO:0004382,GO:0005794,GO:0006254,GO:0006256,GO:0009134,GO:0016020,GO:0016021,GO:0017110,GO:0017111,GO:0030659,GO:0030666,GO:0034656,GO:0043273,GO:0045134,GO:0046039,GO:0046052,GO:0046872,GO:0050776,GO:0072539" GTPase activity|guanosine-diphosphatase activity|Golgi apparatus|CTP catabolic process|UDP catabolic process|nucleoside diphosphate catabolic process|membrane|integral component of membrane|nucleoside-diphosphatase activity|nucleoside-triphosphatase activity|cytoplasmic vesicle membrane|endocytic vesicle membrane|nucleobase-containing small molecule catabolic process|CTPase activity|uridine-diphosphatase activity|GTP metabolic process|UTP catabolic process|metal ion binding|regulation of immune response|T-helper 17 cell differentiation ENTPD8 5.524131538 6.242483296 4.80577978 0.769850643 -0.377349516 0.927604977 1 0.152471332 0.115415955 377841 ectonucleoside triphosphate diphosphohydrolase 8 "GO:0004382,GO:0005524,GO:0005886,GO:0009124,GO:0009133,GO:0009134,GO:0016020,GO:0016021,GO:0017110,GO:0017111,GO:0034656,GO:0045134,GO:0046872,GO:0102485,GO:0102486,GO:0102487,GO:0102488,GO:0102489,GO:0102490,GO:0102491" guanosine-diphosphatase activity|ATP binding|plasma membrane|nucleoside monophosphate biosynthetic process|nucleoside diphosphate biosynthetic process|nucleoside diphosphate catabolic process|membrane|integral component of membrane|nucleoside-diphosphatase activity|nucleoside-triphosphatase activity|nucleobase-containing small molecule catabolic process|uridine-diphosphatase activity|metal ion binding|dATP phosphohydrolase activity|dCTP phosphohydrolase activity|dUTP phosphohydrolase activity|dTTP phosphohydrolase activity|GTP phosphohydrolase activity|8-oxo-dGTP phosphohydrolase activity|dGTP phosphohydrolase activity "hsa00230,hsa00240,hsa05169" Purine metabolism|Pyrimidine metabolism|Epstein-Barr virus infection ENTR1 1128.211082 1256.81997 999.6021942 0.795342386 -0.330352036 0.174498962 1 27.07879365 21.1765213 10807 endosome associated trafficking regulator 1 "GO:0005515,GO:0005768,GO:0005769,GO:0005813,GO:0007049,GO:0015031,GO:0030030,GO:0030496,GO:0030904,GO:0032465,GO:0036064,GO:0045724,GO:0051301,GO:0055037,GO:1903566,GO:1990126" "protein binding|endosome|early endosome|centrosome|cell cycle|protein transport|cell projection organization|midbody|retromer complex|regulation of cytokinesis|ciliary basal body|positive regulation of cilium assembly|cell division|recycling endosome|positive regulation of protein localization to cilium|retrograde transport, endosome to plasma membrane" ENY2 929.7448957 828.1694506 1031.320341 1.245301116 0.31649463 0.201180712 1 15.62314651 19.12995997 56943 ENY2 transcription and export complex 2 subunit "GO:0000124,GO:0003682,GO:0003713,GO:0005515,GO:0005654,GO:0005739,GO:0006357,GO:0006368,GO:0016578,GO:0016973,GO:0030374,GO:0044615,GO:0045893,GO:0061179,GO:0070390,GO:0071819" "SAGA complex|chromatin binding|transcription coactivator activity|protein binding|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|histone deubiquitination|poly(A)+ mRNA export from nucleus|nuclear receptor coactivator activity|nuclear pore nuclear basket|positive regulation of transcription, DNA-templated|negative regulation of insulin secretion involved in cellular response to glucose stimulus|transcription export complex 2|DUBm complex" EOGT 721.0457199 749.0979955 692.9934443 0.925103856 -0.112312757 0.663171659 1 7.504783788 6.826527665 285203 EGF domain specific O-linked N-acetylglucosamine transferase "GO:0005788,GO:0006493,GO:0016262,GO:0016757,GO:0018215,GO:0097363,GO:0097370" "endoplasmic reticulum lumen|protein O-linked glycosylation|protein N-acetylglucosaminyltransferase activity|transferase activity, transferring glycosyl groups|protein phosphopantetheinylation|protein O-GlcNAc transferase activity|protein O-GlcNAcylation via threonine" hsa00514 Other types of O-glycan biosynthesis EOLA1 281.7407693 293.3967149 270.0848236 0.920544812 -0.119440142 0.718880329 1 1.910682542 1.729436612 91966 endothelium and lymphocyte associated ASCH domain 1 "GO:0005515,GO:0010468,GO:0032675" protein binding|regulation of gene expression|regulation of interleukin-6 production EOLA2 603.4638599 551.4193578 655.508362 1.188765597 0.24946427 0.343420617 1 3.520966458 4.115563382 541578 endothelium and lymphocyte associated ASCH domain 2 EOMES 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.046948966 0 8320 eomesodermin "GO:0000122,GO:0000978,GO:0000981,GO:0001102,GO:0001706,GO:0001707,GO:0001708,GO:0001714,GO:0001947,GO:0002250,GO:0002302,GO:0003677,GO:0005634,GO:0006357,GO:0007420,GO:0043433,GO:0043565,GO:0045893,GO:0045944,GO:0060706,GO:0060809,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II activating transcription factor binding|endoderm formation|mesoderm formation|cell fate specification|endodermal cell fate specification|heart looping|adaptive immune response|CD8-positive, alpha-beta T cell differentiation involved in immune response|DNA binding|nucleus|regulation of transcription by RNA polymerase II|brain development|negative regulation of DNA-binding transcription factor activity|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cell differentiation involved in embryonic placenta development|mesodermal to mesenchymal transition involved in gastrulation|sequence-specific double-stranded DNA binding" T-box EP300 2020.087854 2339.890822 1700.284886 0.726651376 -0.460664723 0.051636556 1 14.22436184 10.1631906 2033 E1A binding protein p300 "GO:0000122,GO:0000123,GO:0000977,GO:0000978,GO:0001085,GO:0001102,GO:0001666,GO:0001756,GO:0001966,GO:0002039,GO:0002209,GO:0002223,GO:0003677,GO:0003682,GO:0003684,GO:0003713,GO:0004402,GO:0004468,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005694,GO:0005829,GO:0006110,GO:0006283,GO:0006355,GO:0006473,GO:0006475,GO:0006915,GO:0006977,GO:0006990,GO:0007219,GO:0007221,GO:0007399,GO:0007507,GO:0007519,GO:0007611,GO:0007623,GO:0008013,GO:0008022,GO:0008134,GO:0008270,GO:0009887,GO:0010506,GO:0010742,GO:0010821,GO:0010976,GO:0016032,GO:0016407,GO:0016573,GO:0016579,GO:0016746,GO:0018076,GO:0018215,GO:0018393,GO:0018394,GO:0030183,GO:0030220,GO:0030324,GO:0030511,GO:0031333,GO:0031490,GO:0031648,GO:0032092,GO:0032481,GO:0032993,GO:0033613,GO:0034644,GO:0035257,GO:0035264,GO:0035855,GO:0036268,GO:0042771,GO:0043627,GO:0043923,GO:0043967,GO:0043969,GO:0045444,GO:0045652,GO:0045721,GO:0045747,GO:0045815,GO:0045893,GO:0045944,GO:0048156,GO:0050681,GO:0050821,GO:0051059,GO:0051091,GO:0051726,GO:0060325,GO:0060765,GO:0061418,GO:0061733,GO:0061920,GO:0061921,GO:0090043,GO:0097157,GO:0097677,GO:0140065,GO:0140066,GO:0140067,GO:0140068,GO:0140069,GO:1900034,GO:1901224,GO:1901796,GO:1904837,GO:1905636" "negative regulation of transcription by RNA polymerase II|histone acetyltransferase complex|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|response to hypoxia|somitogenesis|thigmotaxis|p53 binding|behavioral defense response|stimulatory C-type lectin receptor signaling pathway|DNA binding|chromatin binding|damaged DNA binding|transcription coactivator activity|histone acetyltransferase activity|lysine N-acetyltransferase activity, acting on acetyl phosphate as donor|protein binding|nucleus|nucleoplasm|transcription regulator complex|chromosome|cytosol|regulation of glycolytic process|transcription-coupled nucleotide-excision repair|regulation of transcription, DNA-templated|protein acetylation|internal protein amino acid acetylation|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|Notch signaling pathway|positive regulation of transcription of Notch receptor target|nervous system development|heart development|skeletal muscle tissue development|learning or memory|circadian rhythm|beta-catenin binding|protein C-terminus binding|transcription factor binding|zinc ion binding|animal organ morphogenesis|regulation of autophagy|macrophage derived foam cell differentiation|regulation of mitochondrion organization|positive regulation of neuron projection development|viral process|acetyltransferase activity|histone acetylation|protein deubiquitination|transferase activity, transferring acyl groups|N-terminal peptidyl-lysine acetylation|protein phosphopantetheinylation|internal peptidyl-lysine acetylation|peptidyl-lysine acetylation|B cell differentiation|platelet formation|lung development|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of protein-containing complex assembly|chromatin DNA binding|protein destabilization|positive regulation of protein binding|positive regulation of type I interferon production|protein-DNA complex|activating transcription factor binding|cellular response to UV|nuclear hormone receptor binding|multicellular organism growth|megakaryocyte development|swimming|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|response to estrogen|positive regulation by host of viral transcription|histone H4 acetylation|histone H2B acetylation|fat cell differentiation|regulation of megakaryocyte differentiation|negative regulation of gluconeogenesis|positive regulation of Notch signaling pathway|positive regulation of gene expression, epigenetic|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|tau protein binding|androgen receptor binding|protein stabilization|NF-kappaB binding|positive regulation of DNA-binding transcription factor activity|regulation of cell cycle|face morphogenesis|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|peptide-lysine-N-acetyltransferase activity|protein propionyltransferase activity|peptidyl-lysine propionylation|regulation of tubulin deacetylation|pre-mRNA intronic binding|STAT family protein binding|peptide butyryltransferase activity|peptidyl-lysine crotonylation|peptidyl-lysine butyrylation|histone crotonyltransferase activity|histone butyryltransferase activity|regulation of cellular response to heat|positive regulation of NIK/NF-kappaB signaling|regulation of signal transduction by p53 class mediator|beta-catenin-TCF complex assembly|positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding" "hsa04024,hsa04066,hsa04068,hsa04110,hsa04310,hsa04330,hsa04350,hsa04520,hsa04630,hsa04720,hsa04916,hsa04919,hsa04922,hsa04935,hsa05016,hsa05152,hsa05161,hsa05164,hsa05165,hsa05166,hsa05167,hsa05200,hsa05203,hsa05206,hsa05211,hsa05215" "cAMP signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Cell cycle|Wnt signaling pathway|Notch signaling pathway|TGF-beta signaling pathway|Adherens junction|JAK-STAT signaling pathway|Long-term potentiation|Melanogenesis|Thyroid hormone signaling pathway|Glucagon signaling pathway|Growth hormone synthesis, secretion and action|Huntington disease|Tuberculosis|Hepatitis B|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Viral carcinogenesis|MicroRNAs in cancer|Renal cell carcinoma|Prostate cancer" other EP400 2238.813772 2581.266843 1896.360701 0.73466279 -0.444845889 0.059980082 1 11.20981913 8.097628112 57634 E1A binding protein p400 "GO:0000812,GO:0003677,GO:0003682,GO:0004386,GO:0005515,GO:0005524,GO:0005654,GO:0016607,GO:0035267,GO:0043967,GO:0043968,GO:1990405" Swr1 complex|DNA binding|chromatin binding|helicase activity|protein binding|ATP binding|nucleoplasm|nuclear speck|NuA4 histone acetyltransferase complex|histone H4 acetylation|histone H2A acetylation|protein antigen binding EPAS1 4698.381413 5141.725408 4255.037417 0.827550497 -0.273080747 0.25413157 1 50.35867773 40.976985 2034 endothelial PAS domain protein 1 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001525,GO:0001666,GO:0001892,GO:0001974,GO:0002027,GO:0003677,GO:0005515,GO:0005654,GO:0005667,GO:0005829,GO:0006357,GO:0007005,GO:0007165,GO:0007601,GO:0008134,GO:0016567,GO:0016607,GO:0030218,GO:0030324,GO:0035035,GO:0042415,GO:0043129,GO:0043565,GO:0043619,GO:0043687,GO:0045944,GO:0046982,GO:0048469,GO:0048625,GO:0055072,GO:0061418,GO:0071456,GO:0120162,GO:2000434" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|response to hypoxia|embryonic placenta development|blood vessel remodeling|regulation of heart rate|DNA binding|protein binding|nucleoplasm|transcription regulator complex|cytosol|regulation of transcription by RNA polymerase II|mitochondrion organization|signal transduction|visual perception|transcription factor binding|protein ubiquitination|nuclear speck|erythrocyte differentiation|lung development|histone acetyltransferase binding|norepinephrine metabolic process|surfactant homeostasis|sequence-specific DNA binding|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|post-translational protein modification|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|cell maturation|myoblast fate commitment|iron ion homeostasis|regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to hypoxia|positive regulation of cold-induced thermogenesis|regulation of protein neddylation" "hsa05200,hsa05211" Pathways in cancer|Renal cell carcinoma other EPB41 838.7319899 886.432628 791.0313518 0.892376168 -0.16427611 0.513315977 1 2.960961392 2.598076213 2035 erythrocyte membrane protein band 4.1 "GO:0003779,GO:0005200,GO:0005515,GO:0005516,GO:0005545,GO:0005829,GO:0005856,GO:0005886,GO:0007049,GO:0008022,GO:0008360,GO:0009898,GO:0014069,GO:0014731,GO:0016323,GO:0016604,GO:0030036,GO:0030054,GO:0030507,GO:0030863,GO:0030866,GO:0031032,GO:0032092,GO:0032991,GO:0045171,GO:0047485,GO:0051219,GO:0051301,GO:0051924,GO:0065003,GO:0072686,GO:0099738,GO:1904478,GO:1904778" actin binding|structural constituent of cytoskeleton|protein binding|calmodulin binding|1-phosphatidylinositol binding|cytosol|cytoskeleton|plasma membrane|cell cycle|protein C-terminus binding|regulation of cell shape|cytoplasmic side of plasma membrane|postsynaptic density|spectrin-associated cytoskeleton|basolateral plasma membrane|nuclear body|actin cytoskeleton organization|cell junction|spectrin binding|cortical cytoskeleton|cortical actin cytoskeleton organization|actomyosin structure organization|positive regulation of protein binding|protein-containing complex|intercellular bridge|protein N-terminus binding|phosphoprotein binding|cell division|regulation of calcium ion transport|protein-containing complex assembly|mitotic spindle|cell cortex region|regulation of intestinal absorption|positive regulation of protein localization to cell cortex EPB41L1 1906.089535 1895.634094 1916.544976 1.011031075 0.015827341 0.949093066 1 9.53771166 9.481561619 2036 erythrocyte membrane protein band 4.1 like 1 "GO:0003779,GO:0005198,GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0030866,GO:0031032" actin binding|structural molecule activity|protein binding|cytosol|cytoskeleton|plasma membrane|cortical actin cytoskeleton organization|actomyosin structure organization EPB41L2 3423.512831 3390.708844 3456.316818 1.019349339 0.027648559 0.908439643 1 33.64743383 33.72455065 2037 erythrocyte membrane protein band 4.1 like 2 "GO:0003779,GO:0005198,GO:0005515,GO:0005654,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0007049,GO:0008091,GO:0008180,GO:0030054,GO:0030507,GO:0030866,GO:0031032,GO:0042731,GO:0051301,GO:0070062,GO:0099738,GO:1904778" actin binding|structural molecule activity|protein binding|nucleoplasm|cytosol|cytoskeleton|plasma membrane|focal adhesion|cell cycle|spectrin|COP9 signalosome|cell junction|spectrin binding|cortical actin cytoskeleton organization|actomyosin structure organization|PH domain binding|cell division|extracellular exosome|cell cortex region|positive regulation of protein localization to cell cortex EPB41L3 218.9045554 195.5978099 242.2113009 1.238312949 0.308375962 0.38329545 1 1.959950361 2.38641882 23136 erythrocyte membrane protein band 4.1 like 3 "GO:0001558,GO:0002175,GO:0003779,GO:0005200,GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0005911,GO:0006915,GO:0008150,GO:0008360,GO:0030054,GO:0030673,GO:0030865,GO:0030866,GO:0030913,GO:0031032,GO:0033270,GO:0043217,GO:0044224,GO:0048812,GO:0071205,GO:0072659,GO:0106006" regulation of cell growth|protein localization to paranode region of axon|actin binding|structural constituent of cytoskeleton|protein binding|cytosol|cytoskeleton|plasma membrane|cell-cell junction|apoptotic process|biological_process|regulation of cell shape|cell junction|axolemma|cortical cytoskeleton organization|cortical actin cytoskeleton organization|paranodal junction assembly|actomyosin structure organization|paranode region of axon|myelin maintenance|juxtaparanode region of axon|neuron projection morphogenesis|protein localization to juxtaparanode region of axon|protein localization to plasma membrane|cytoskeletal protein-membrane anchor activity EPB41L4A 396.8461262 375.5894116 418.1028409 1.113191235 0.154701454 0.598337003 1 2.440881222 2.671699461 64097 erythrocyte membrane protein band 4.1 like 4A "GO:0003674,GO:0005575,GO:0005737,GO:0005856,GO:0008092,GO:0008150,GO:0031032" molecular_function|cellular_component|cytoplasm|cytoskeleton|cytoskeletal protein binding|biological_process|actomyosin structure organization EPB41L4B 216.5312337 221.608157 211.4543103 0.954181079 -0.067665017 0.860360491 1 1.477060078 1.385798666 54566 erythrocyte membrane protein band 4.1 like 4B "GO:0005200,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005923,GO:0008092,GO:0010628,GO:0010837,GO:0031032,GO:0042060,GO:0045177,GO:0045785,GO:0051549" structural constituent of cytoskeleton|cytoplasm|cytosol|cytoskeleton|plasma membrane|bicellular tight junction|cytoskeletal protein binding|positive regulation of gene expression|regulation of keratinocyte proliferation|actomyosin structure organization|wound healing|apical part of cell|positive regulation of cell adhesion|positive regulation of keratinocyte migration hsa04530 Tight junction EPB41L5 937.7411142 861.4626948 1014.019534 1.177090476 0.235225216 0.342246517 1 4.158346664 4.812843238 57669 erythrocyte membrane protein band 4.1 like 5 "GO:0001701,GO:0001837,GO:0001839,GO:0001917,GO:0003383,GO:0005515,GO:0005654,GO:0005829,GO:0005856,GO:0005886,GO:0005912,GO:0005925,GO:0006931,GO:0007398,GO:0007492,GO:0007509,GO:0008092,GO:0009826,GO:0010608,GO:0010634,GO:0019904,GO:0022408,GO:0031032,GO:0032091,GO:0032092,GO:0032525,GO:0032587,GO:0048319,GO:0048339,GO:0048617,GO:0051894,GO:0070201,GO:0070986,GO:0071560" "in utero embryonic development|epithelial to mesenchymal transition|neural plate morphogenesis|photoreceptor inner segment|apical constriction|protein binding|nucleoplasm|cytosol|cytoskeleton|plasma membrane|adherens junction|focal adhesion|substrate-dependent cell migration, cell attachment to substrate|ectoderm development|endoderm development|mesoderm migration involved in gastrulation|cytoskeletal protein binding|unidimensional cell growth|posttranscriptional regulation of gene expression|positive regulation of epithelial cell migration|protein domain specific binding|negative regulation of cell-cell adhesion|actomyosin structure organization|negative regulation of protein binding|positive regulation of protein binding|somite rostral/caudal axis specification|ruffle membrane|axial mesoderm morphogenesis|paraxial mesoderm development|embryonic foregut morphogenesis|positive regulation of focal adhesion assembly|regulation of establishment of protein localization|left/right axis specification|cellular response to transforming growth factor beta stimulus" EPC1 252.5544603 271.5480234 233.5608973 0.860108994 -0.217408603 0.519817773 1 2.944335417 2.490072264 80314 enhancer of polycomb homolog 1 "GO:0000122,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0006351,GO:0006357,GO:0031965,GO:0032777,GO:0035267,GO:0035886,GO:0040008,GO:0043231,GO:0043967,GO:0043968,GO:0045814,GO:0045892,GO:0045893,GO:0045944,GO:0070317" "negative regulation of transcription by RNA polymerase II|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex|NuA4 histone acetyltransferase complex|vascular associated smooth muscle cell differentiation|regulation of growth|intracellular membrane-bounded organelle|histone H4 acetylation|histone H2A acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of G0 to G1 transition" EPC2 474.0399288 522.2877691 425.7920885 0.815244227 -0.294695775 0.287700717 1 5.533757854 4.435872574 26122 enhancer of polycomb homolog 2 "GO:0004402,GO:0006281,GO:0006357,GO:0016573,GO:0032777" histone acetyltransferase activity|DNA repair|regulation of transcription by RNA polymerase II|histone acetylation|Piccolo NuA4 histone acetyltransferase complex EPCAM 44.6786607 37.45489978 51.90242162 1.385731158 0.470647391 0.46385159 1 1.292113227 1.760559604 4072 epithelial cell adhesion molecule "GO:0005515,GO:0005886,GO:0005923,GO:0008284,GO:0016021,GO:0016323,GO:0016324,GO:0016328,GO:0023019,GO:0044877,GO:0045944,GO:0048863,GO:0050900,GO:0070062,GO:0098609,GO:0098641,GO:2000048,GO:2000648" protein binding|plasma membrane|bicellular tight junction|positive regulation of cell population proliferation|integral component of membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|signal transduction involved in regulation of gene expression|protein-containing complex binding|positive regulation of transcription by RNA polymerase II|stem cell differentiation|leukocyte migration|extracellular exosome|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|negative regulation of cell-cell adhesion mediated by cadherin|positive regulation of stem cell proliferation EPG5 2224.908422 2304.51675 2145.300094 0.930911044 -0.103284782 0.663223359 1 8.315606723 7.611553476 57724 ectopic P-granules autophagy protein 5 homolog "GO:0005515,GO:0005737,GO:0005764,GO:0006862,GO:0008333,GO:0032456,GO:0034162,GO:0048471,GO:0097352,GO:1990786" protein binding|cytoplasm|lysosome|nucleotide transport|endosome to lysosome transport|endocytic recycling|toll-like receptor 9 signaling pathway|perinuclear region of cytoplasm|autophagosome maturation|cellular response to dsDNA EPGN 38.19337321 31.21241648 45.17432993 1.447319209 0.533383146 0.432922692 1 0.488060153 0.694558541 255324 epithelial mitogen "GO:0000165,GO:0000187,GO:0001525,GO:0005154,GO:0005515,GO:0005576,GO:0005615,GO:0005887,GO:0007165,GO:0007173,GO:0008083,GO:0008284,GO:0030665,GO:0042059,GO:0043406,GO:0045741,GO:0045840,GO:0050679,GO:0051897,GO:0061024" MAPK cascade|activation of MAPK activity|angiogenesis|epidermal growth factor receptor binding|protein binding|extracellular region|extracellular space|integral component of plasma membrane|signal transduction|epidermal growth factor receptor signaling pathway|growth factor activity|positive regulation of cell population proliferation|clathrin-coated vesicle membrane|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of epidermal growth factor-activated receptor activity|positive regulation of mitotic nuclear division|positive regulation of epithelial cell proliferation|positive regulation of protein kinase B signaling|membrane organization EPHA10 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.023909133 0.014478763 284656 EPH receptor A10 "GO:0004714,GO:0005005,GO:0005515,GO:0005524,GO:0005576,GO:0005886,GO:0005887,GO:0007169,GO:0007275,GO:0007411,GO:0008150,GO:0018108,GO:0033674,GO:0043005,GO:0043235,GO:0048013" transmembrane receptor protein tyrosine kinase activity|transmembrane-ephrin receptor activity|protein binding|ATP binding|extracellular region|plasma membrane|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|biological_process|peptidyl-tyrosine phosphorylation|positive regulation of kinase activity|neuron projection|receptor complex|ephrin receptor signaling pathway EPHA2 3932.36258 3893.228749 3971.49641 1.020103535 0.028715586 0.905018591 1 48.6591248 48.80673147 1969 EPH receptor A2 "GO:0001501,GO:0001570,GO:0001618,GO:0001649,GO:0002043,GO:0004714,GO:0005005,GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0005925,GO:0006954,GO:0007155,GO:0007169,GO:0007275,GO:0007411,GO:0008630,GO:0009986,GO:0010591,GO:0014028,GO:0016477,GO:0016525,GO:0018108,GO:0021915,GO:0030027,GO:0030216,GO:0030316,GO:0031256,GO:0031258,GO:0032587,GO:0032682,GO:0033598,GO:0033628,GO:0033674,GO:0036342,GO:0043005,GO:0043235,GO:0043491,GO:0043535,GO:0045296,GO:0045765,GO:0046058,GO:0046718,GO:0046849,GO:0048013,GO:0048320,GO:0048870,GO:0050830,GO:0051898,GO:0060035,GO:0060326,GO:0060444,GO:0070160,GO:0070309,GO:0070372,GO:0070848,GO:0072659,GO:0090630,GO:1901491,GO:1903078,GO:1903348,GO:1904238" skeletal system development|vasculogenesis|virus receptor activity|osteoblast differentiation|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|transmembrane receptor protein tyrosine kinase activity|transmembrane-ephrin receptor activity|protein binding|ATP binding|plasma membrane|integral component of plasma membrane|focal adhesion|inflammatory response|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|intrinsic apoptotic signaling pathway in response to DNA damage|cell surface|regulation of lamellipodium assembly|notochord formation|cell migration|negative regulation of angiogenesis|peptidyl-tyrosine phosphorylation|neural tube development|lamellipodium|keratinocyte differentiation|osteoclast differentiation|leading edge membrane|lamellipodium membrane|ruffle membrane|negative regulation of chemokine production|mammary gland epithelial cell proliferation|regulation of cell adhesion mediated by integrin|positive regulation of kinase activity|post-anal tail morphogenesis|neuron projection|receptor complex|protein kinase B signaling|regulation of blood vessel endothelial cell migration|cadherin binding|regulation of angiogenesis|cAMP metabolic process|viral entry into host cell|bone remodeling|ephrin receptor signaling pathway|axial mesoderm formation|cell motility|defense response to Gram-positive bacterium|negative regulation of protein kinase B signaling|notochord cell development|cell chemotaxis|branching involved in mammary gland duct morphogenesis|tight junction|lens fiber cell morphogenesis|regulation of ERK1 and ERK2 cascade|response to growth factor|protein localization to plasma membrane|activation of GTPase activity|negative regulation of lymphangiogenesis|positive regulation of protein localization to plasma membrane|positive regulation of bicellular tight junction assembly|pericyte cell differentiation "hsa04010,hsa04014,hsa04015,hsa04151,hsa04360" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Axon guidance EPHA3 66.33926825 50.98028025 81.69825626 1.602546237 0.680365982 0.210778775 1 0.870074787 1.371002766 2042 EPH receptor A3 "GO:0004714,GO:0005003,GO:0005004,GO:0005005,GO:0005515,GO:0005524,GO:0005576,GO:0005654,GO:0005769,GO:0005829,GO:0005886,GO:0005887,GO:0007155,GO:0007169,GO:0007275,GO:0007411,GO:0010717,GO:0010976,GO:0015629,GO:0016477,GO:0018108,GO:0031965,GO:0032956,GO:0033674,GO:0043005,GO:0043087,GO:0043235,GO:0045806,GO:0048013,GO:0051893,GO:0070507,GO:0071300,GO:0097155,GO:0097156,GO:1903078" transmembrane receptor protein tyrosine kinase activity|ephrin receptor activity|GPI-linked ephrin receptor activity|transmembrane-ephrin receptor activity|protein binding|ATP binding|extracellular region|nucleoplasm|early endosome|cytosol|plasma membrane|integral component of plasma membrane|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|regulation of epithelial to mesenchymal transition|positive regulation of neuron projection development|actin cytoskeleton|cell migration|peptidyl-tyrosine phosphorylation|nuclear membrane|regulation of actin cytoskeleton organization|positive regulation of kinase activity|neuron projection|regulation of GTPase activity|receptor complex|negative regulation of endocytosis|ephrin receptor signaling pathway|regulation of focal adhesion assembly|regulation of microtubule cytoskeleton organization|cellular response to retinoic acid|fasciculation of sensory neuron axon|fasciculation of motor neuron axon|positive regulation of protein localization to plasma membrane hsa04360 Axon guidance EPHA4 304.9720585 285.0734038 324.8707131 1.139603726 0.188532243 0.552098394 1 2.293659524 2.570123482 2043 EPH receptor A4 "GO:0001540,GO:0004672,GO:0004714,GO:0005004,GO:0005005,GO:0005515,GO:0005524,GO:0005737,GO:0005741,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0005912,GO:0007155,GO:0007169,GO:0007275,GO:0007411,GO:0007628,GO:0008045,GO:0008347,GO:0009986,GO:0010977,GO:0016301,GO:0018108,GO:0021957,GO:0030175,GO:0030424,GO:0030425,GO:0031594,GO:0031901,GO:0033674,GO:0034332,GO:0042731,GO:0042802,GO:0043005,GO:0043087,GO:0043197,GO:0043198,GO:0043204,GO:0043235,GO:0043507,GO:0043679,GO:0044295,GO:0046777,GO:0046875,GO:0048013,GO:0048681,GO:0048710,GO:0050770,GO:0050775,GO:0050821,GO:0061001,GO:0061098,GO:0072178,GO:0090102,GO:0097155,GO:0097156,GO:0097161,GO:0097485,GO:0098685,GO:0098839,GO:0098883,GO:0098978,GO:0099055,GO:0099056,GO:0106030,GO:1900272,GO:1902004,GO:1902961,GO:1903051,GO:1904646,GO:1905244,GO:1990782,GO:2001108" amyloid-beta binding|protein kinase activity|transmembrane receptor protein tyrosine kinase activity|GPI-linked ephrin receptor activity|transmembrane-ephrin receptor activity|protein binding|ATP binding|cytoplasm|mitochondrial outer membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|adherens junction|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|adult walking behavior|motor neuron axon guidance|glial cell migration|cell surface|negative regulation of neuron projection development|kinase activity|peptidyl-tyrosine phosphorylation|corticospinal tract morphogenesis|filopodium|axon|dendrite|neuromuscular junction|early endosome membrane|positive regulation of kinase activity|adherens junction organization|PH domain binding|identical protein binding|neuron projection|regulation of GTPase activity|dendritic spine|dendritic shaft|perikaryon|receptor complex|positive regulation of JUN kinase activity|axon terminus|axonal growth cone|protein autophosphorylation|ephrin receptor binding|ephrin receptor signaling pathway|negative regulation of axon regeneration|regulation of astrocyte differentiation|regulation of axonogenesis|positive regulation of dendrite morphogenesis|protein stabilization|regulation of dendritic spine morphogenesis|positive regulation of protein tyrosine kinase activity|nephric duct morphogenesis|cochlea development|fasciculation of sensory neuron axon|fasciculation of motor neuron axon|DH domain binding|neuron projection guidance|Schaffer collateral - CA1 synapse|postsynaptic density membrane|synapse pruning|glutamatergic synapse|integral component of postsynaptic membrane|integral component of presynaptic membrane|neuron projection fasciculation|negative regulation of long-term synaptic potentiation|positive regulation of amyloid-beta formation|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of proteolysis involved in cellular protein catabolic process|cellular response to amyloid-beta|regulation of modification of synaptic structure|protein tyrosine kinase binding|positive regulation of Rho guanyl-nucleotide exchange factor activity hsa04360 Axon guidance EPHA6 3.121241648 6.242483296 0 0 #NAME? 0.093640883 1 0.014618889 0 285220 EPH receptor A6 "GO:0003674,GO:0004714,GO:0005005,GO:0005524,GO:0005654,GO:0005886,GO:0005887,GO:0007169,GO:0007275,GO:0007411,GO:0008150,GO:0018108,GO:0033674,GO:0043005,GO:0043235,GO:0048013" molecular_function|transmembrane receptor protein tyrosine kinase activity|transmembrane-ephrin receptor activity|ATP binding|nucleoplasm|plasma membrane|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|biological_process|peptidyl-tyrosine phosphorylation|positive regulation of kinase activity|neuron projection|receptor complex|ephrin receptor signaling pathway hsa04360 Axon guidance EPHB1 12.97057499 12.48496659 13.45618338 1.0777909 0.108077311 1 1 0.093897931 0.099508852 2047 EPH receptor B1 "GO:0001525,GO:0004714,GO:0005005,GO:0005515,GO:0005524,GO:0005576,GO:0005783,GO:0005829,GO:0005886,GO:0005887,GO:0007169,GO:0007275,GO:0007411,GO:0014719,GO:0018108,GO:0021952,GO:0022008,GO:0030010,GO:0030425,GO:0031290,GO:0031589,GO:0031901,GO:0033674,GO:0043005,GO:0043235,GO:0046328,GO:0046777,GO:0048013,GO:0050965,GO:0051965,GO:0060326,GO:0060996,GO:0060997,GO:0061351,GO:0070062,GO:0070372,GO:1901214,GO:1902723,GO:1902725" angiogenesis|transmembrane receptor protein tyrosine kinase activity|transmembrane-ephrin receptor activity|protein binding|ATP binding|extracellular region|endoplasmic reticulum|cytosol|plasma membrane|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|skeletal muscle satellite cell activation|peptidyl-tyrosine phosphorylation|central nervous system projection neuron axonogenesis|neurogenesis|establishment of cell polarity|dendrite|retinal ganglion cell axon guidance|cell-substrate adhesion|early endosome membrane|positive regulation of kinase activity|neuron projection|receptor complex|regulation of JNK cascade|protein autophosphorylation|ephrin receptor signaling pathway|detection of temperature stimulus involved in sensory perception of pain|positive regulation of synapse assembly|cell chemotaxis|dendritic spine development|dendritic spine morphogenesis|neural precursor cell proliferation|extracellular exosome|regulation of ERK1 and ERK2 cascade|regulation of neuron death|negative regulation of skeletal muscle satellite cell proliferation|negative regulation of satellite cell differentiation hsa04360 Axon guidance EPHB2 1153.250827 1232.890451 1073.611203 0.870808272 -0.199572983 0.412006543 1 5.76712222 4.938020399 2048 EPH receptor B2 "GO:0001525,GO:0001540,GO:0001655,GO:0001933,GO:0004713,GO:0004714,GO:0005005,GO:0005102,GO:0005515,GO:0005524,GO:0005576,GO:0005654,GO:0005829,GO:0005886,GO:0005887,GO:0007169,GO:0007275,GO:0007399,GO:0007411,GO:0007413,GO:0007611,GO:0007612,GO:0008046,GO:0010628,GO:0016310,GO:0018108,GO:0021631,GO:0021952,GO:0022038,GO:0030193,GO:0030424,GO:0030425,GO:0031290,GO:0031915,GO:0033674,GO:0042472,GO:0042802,GO:0043005,GO:0043025,GO:0043235,GO:0044877,GO:0046580,GO:0048013,GO:0048168,GO:0048170,GO:0048593,GO:0050771,GO:0050878,GO:0051389,GO:0051965,GO:0060021,GO:0060996,GO:0060997,GO:0070373,GO:0071679,GO:0097104,GO:0098794,GO:0098978,GO:0099055,GO:0099056,GO:0099557,GO:0106028,GO:1900273,GO:1903078,GO:1904782,GO:1904783" "angiogenesis|amyloid-beta binding|urogenital system development|negative regulation of protein phosphorylation|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|transmembrane-ephrin receptor activity|signaling receptor binding|protein binding|ATP binding|extracellular region|nucleoplasm|cytosol|plasma membrane|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|nervous system development|axon guidance|axonal fasciculation|learning or memory|learning|axon guidance receptor activity|positive regulation of gene expression|phosphorylation|peptidyl-tyrosine phosphorylation|optic nerve morphogenesis|central nervous system projection neuron axonogenesis|corpus callosum development|regulation of blood coagulation|axon|dendrite|retinal ganglion cell axon guidance|positive regulation of synaptic plasticity|positive regulation of kinase activity|inner ear morphogenesis|identical protein binding|neuron projection|neuronal cell body|receptor complex|protein-containing complex binding|negative regulation of Ras protein signal transduction|ephrin receptor signaling pathway|regulation of neuronal synaptic plasticity|positive regulation of long-term neuronal synaptic plasticity|camera-type eye morphogenesis|negative regulation of axonogenesis|regulation of body fluid levels|inactivation of MAPKK activity|positive regulation of synapse assembly|roof of mouth development|dendritic spine development|dendritic spine morphogenesis|negative regulation of ERK1 and ERK2 cascade|commissural neuron axon guidance|postsynaptic membrane assembly|postsynapse|glutamatergic synapse|integral component of postsynaptic membrane|integral component of presynaptic membrane|trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission|neuron projection retraction|positive regulation of long-term synaptic potentiation|positive regulation of protein localization to plasma membrane|negative regulation of NMDA glutamate receptor activity|positive regulation of NMDA glutamate receptor activity" hsa04360 Axon guidance EPHB3 6.524916457 7.282897178 5.766935736 0.791846376 -0.336707531 0.922510643 1 0.091798497 0.071473933 2049 EPH receptor B3 "GO:0001525,GO:0001655,GO:0004714,GO:0005003,GO:0005005,GO:0005515,GO:0005524,GO:0005576,GO:0005829,GO:0005886,GO:0005887,GO:0007169,GO:0007275,GO:0007411,GO:0007413,GO:0008046,GO:0016477,GO:0018108,GO:0021952,GO:0022038,GO:0022407,GO:0030425,GO:0031290,GO:0033674,GO:0034446,GO:0043005,GO:0043087,GO:0043235,GO:0046777,GO:0048013,GO:0048538,GO:0048546,GO:0050770,GO:0051965,GO:0060021,GO:0060996,GO:0060997" angiogenesis|urogenital system development|transmembrane receptor protein tyrosine kinase activity|ephrin receptor activity|transmembrane-ephrin receptor activity|protein binding|ATP binding|extracellular region|cytosol|plasma membrane|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|axonal fasciculation|axon guidance receptor activity|cell migration|peptidyl-tyrosine phosphorylation|central nervous system projection neuron axonogenesis|corpus callosum development|regulation of cell-cell adhesion|dendrite|retinal ganglion cell axon guidance|positive regulation of kinase activity|substrate adhesion-dependent cell spreading|neuron projection|regulation of GTPase activity|receptor complex|protein autophosphorylation|ephrin receptor signaling pathway|thymus development|digestive tract morphogenesis|regulation of axonogenesis|positive regulation of synapse assembly|roof of mouth development|dendritic spine development|dendritic spine morphogenesis hsa04360 Axon guidance EPHB4 1133.333894 1265.143281 1001.524506 0.791629313 -0.337103061 0.165691301 1 16.84590112 13.11255409 2050 EPH receptor B4 "GO:0001525,GO:0002042,GO:0003007,GO:0004714,GO:0005003,GO:0005005,GO:0005515,GO:0005524,GO:0005576,GO:0005829,GO:0005886,GO:0005887,GO:0007155,GO:0007169,GO:0007275,GO:0007411,GO:0018108,GO:0033674,GO:0043005,GO:0043235,GO:0046777,GO:0048013,GO:0070062" angiogenesis|cell migration involved in sprouting angiogenesis|heart morphogenesis|transmembrane receptor protein tyrosine kinase activity|ephrin receptor activity|transmembrane-ephrin receptor activity|protein binding|ATP binding|extracellular region|cytosol|plasma membrane|integral component of plasma membrane|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|peptidyl-tyrosine phosphorylation|positive regulation of kinase activity|neuron projection|receptor complex|protein autophosphorylation|ephrin receptor signaling pathway|extracellular exosome hsa04360 Axon guidance EPHX1 794.880507 883.3113864 706.4496277 0.799774166 -0.322335414 0.200563751 1 22.49079448 17.68655901 2052 epoxide hydrolase 1 "GO:0004301,GO:0005515,GO:0005789,GO:0006805,GO:0009636,GO:0016021,GO:0019369,GO:0019439,GO:0033961,GO:0097176" epoxide hydrolase activity|protein binding|endoplasmic reticulum membrane|xenobiotic metabolic process|response to toxic substance|integral component of membrane|arachidonic acid metabolic process|aromatic compound catabolic process|cis-stilbene-oxide hydrolase activity|epoxide metabolic process "hsa00980,hsa04976,hsa05204" Metabolism of xenobiotics by cytochrome P450|Bile secretion|Chemical carcinogenesis EPHX2 5.04355356 6.242483296 3.844623824 0.615880514 -0.699277611 0.760739355 1 0.094350003 0.057135964 2053 epoxide hydrolase 2 "GO:0000287,GO:0004301,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0009636,GO:0010628,GO:0015643,GO:0016311,GO:0016787,GO:0016791,GO:0019373,GO:0033885,GO:0042577,GO:0042632,GO:0042759,GO:0042803,GO:0046272,GO:0046839,GO:0052642,GO:0070062,GO:0090181,GO:0097176" magnesium ion binding|epoxide hydrolase activity|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|response to toxic substance|positive regulation of gene expression|toxic substance binding|dephosphorylation|hydrolase activity|phosphatase activity|epoxygenase P450 pathway|10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity|lipid phosphatase activity|cholesterol homeostasis|long-chain fatty acid biosynthetic process|protein homodimerization activity|stilbene catabolic process|phospholipid dephosphorylation|lysophosphatidic acid phosphatase activity|extracellular exosome|regulation of cholesterol metabolic process|epoxide metabolic process "hsa00590,hsa04146" Arachidonic acid metabolism|Peroxisome EPHX4 126.6191068 132.1325631 121.1056505 0.916546592 -0.125719873 0.785775885 1 4.910635127 4.425510667 253152 epoxide hydrolase 4 "GO:0005515,GO:0016021,GO:0016787" protein binding|integral component of membrane|hydrolase activity EPM2A 21.1353702 24.96993318 17.30080721 0.692865579 -0.529352609 0.5500504 1 0.216577189 0.147547847 7957 "EPM2A glucan phosphatase, laforin" "GO:0005515,GO:0005634,GO:0016239,GO:0032007" protein binding|nucleus|positive regulation of macroautophagy|negative regulation of TOR signaling EPM2AIP1 964.1326596 961.3424276 966.9228917 1.005804866 0.008350438 0.977722303 1 6.342573679 6.272640993 9852 EPM2A interacting protein 1 "GO:0005515,GO:0005634,GO:0032868,GO:0042802,GO:0045725,GO:0098554,GO:2000467" protein binding|nucleus|response to insulin|identical protein binding|positive regulation of glycogen biosynthetic process|cytoplasmic side of endoplasmic reticulum membrane|positive regulation of glycogen (starch) synthase activity EPN1 1876.230763 1654.258073 2098.203452 1.268365248 0.342970255 0.147720089 1 5.195051958 6.478961637 29924 epsin 1 "GO:0005515,GO:0005543,GO:0005634,GO:0005768,GO:0005829,GO:0005886,GO:0005905,GO:0006897,GO:0030125,GO:0030276,GO:0042059,GO:0043231,GO:0061024,GO:1903671" protein binding|phospholipid binding|nucleus|endosome|cytosol|plasma membrane|clathrin-coated pit|endocytosis|clathrin vesicle coat|clathrin binding|negative regulation of epidermal growth factor receptor signaling pathway|intracellular membrane-bounded organelle|membrane organization|negative regulation of sprouting angiogenesis hsa04144 Endocytosis EPN2 1520.519999 1462.821919 1578.21808 1.078885994 0.109542423 0.647595485 1 16.14645652 17.12868257 22905 epsin 2 "GO:0005515,GO:0005543,GO:0005768,GO:0005829,GO:0005886,GO:0006897,GO:0030125,GO:0030128,GO:0030276,GO:0030948,GO:0043231,GO:0045296,GO:0045747,GO:0061024,GO:1903671" protein binding|phospholipid binding|endosome|cytosol|plasma membrane|endocytosis|clathrin vesicle coat|clathrin coat of endocytic vesicle|clathrin binding|negative regulation of vascular endothelial growth factor receptor signaling pathway|intracellular membrane-bounded organelle|cadherin binding|positive regulation of Notch signaling pathway|membrane organization|negative regulation of sprouting angiogenesis hsa04144 Endocytosis EPOP 239.4203391 267.3863678 211.4543103 0.790819338 -0.338579946 0.321150329 1 4.383999698 3.408936995 100170841 elongin BC and polycomb repressive complex 2 associated protein "GO:0003682,GO:0005694,GO:0006357,GO:0035098,GO:0035616,GO:0048663,GO:0048863,GO:0070449" chromatin binding|chromosome|regulation of transcription by RNA polymerase II|ESC/E(Z) complex|histone H2B conserved C-terminal lysine deubiquitination|neuron fate commitment|stem cell differentiation|elongin complex EPOR 424.7687244 452.5800389 396.9574098 0.877098802 -0.189188729 0.509458488 1 10.01798626 8.639729152 2057 erythropoietin receptor "GO:0004900,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0007165,GO:0007420,GO:0007507,GO:0014068,GO:0016607,GO:0038162,GO:0042802,GO:0046579,GO:0046697" erythropoietin receptor activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|signal transduction|brain development|heart development|positive regulation of phosphatidylinositol 3-kinase signaling|nuclear speck|erythropoietin-mediated signaling pathway|identical protein binding|positive regulation of Ras protein signal transduction|decidualization "hsa04060,hsa04151,hsa04630,hsa04640,hsa05200" Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|JAK-STAT signaling pathway|Hematopoietic cell lineage|Pathways in cancer EPRS1 4460.406609 5063.694367 3857.118851 0.761720312 -0.392666728 0.100554305 1 55.36571639 41.46747951 2058 glutamyl-prolyl-tRNA synthetase 1 "GO:0004818,GO:0004827,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006418,GO:0006424,GO:0006433,GO:0008270,GO:0016020,GO:0017101,GO:0017148,GO:0032869,GO:0035613,GO:0042802,GO:0042803,GO:0051020,GO:0065003,GO:0071346,GO:0097452,GO:0140212,GO:1990904" glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|tRNA aminoacylation for protein translation|glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|zinc ion binding|membrane|aminoacyl-tRNA synthetase multienzyme complex|negative regulation of translation|cellular response to insulin stimulus|RNA stem-loop binding|identical protein binding|protein homodimerization activity|GTPase binding|protein-containing complex assembly|cellular response to interferon-gamma|GAIT complex|regulation of long-chain fatty acid import into cell|ribonucleoprotein complex "hsa00860,hsa00970" Porphyrin and chlorophyll metabolism|Aminoacyl-tRNA biosynthesis EPS15 1628.029843 1610.56069 1645.498997 1.021693257 0.03096212 0.898988915 1 15.59656396 15.66825518 2060 epidermal growth factor receptor pathway substrate 15 "GO:0001921,GO:0005509,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005905,GO:0006895,GO:0006897,GO:0009925,GO:0016020,GO:0016050,GO:0016197,GO:0016235,GO:0016324,GO:0017124,GO:0019065,GO:0030132,GO:0031593,GO:0031901,GO:0032456,GO:0042059,GO:0042127,GO:0043231,GO:0045296,GO:0046718,GO:0048268,GO:0061024,GO:0098794,GO:0098884,GO:0098978" positive regulation of receptor recycling|calcium ion binding|protein binding|cytoplasm|cytosol|plasma membrane|clathrin-coated pit|Golgi to endosome transport|endocytosis|basal plasma membrane|membrane|vesicle organization|endosomal transport|aggresome|apical plasma membrane|SH3 domain binding|receptor-mediated endocytosis of virus by host cell|clathrin coat of coated pit|polyubiquitin modification-dependent protein binding|early endosome membrane|endocytic recycling|negative regulation of epidermal growth factor receptor signaling pathway|regulation of cell population proliferation|intracellular membrane-bounded organelle|cadherin binding|viral entry into host cell|clathrin coat assembly|membrane organization|postsynapse|postsynaptic neurotransmitter receptor internalization|glutamatergic synapse hsa04144 Endocytosis EPS15L1 859.7289659 857.3010393 862.1568925 1.005664117 0.008148538 0.979204634 1 5.976823098 5.910095991 58513 epidermal growth factor receptor pathway substrate 15 like 1 "GO:0005509,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006897,GO:0016020,GO:0016197,GO:0030132,GO:0042059,GO:0045296,GO:0061024" calcium ion binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|endocytosis|membrane|endosomal transport|clathrin coat of coated pit|negative regulation of epidermal growth factor receptor signaling pathway|cadherin binding|membrane organization hsa04144 Endocytosis EPS8 1613.755929 1652.177246 1575.334612 0.953490079 -0.068710168 0.774741275 1 13.55058599 12.70414475 2059 epidermal growth factor receptor pathway substrate 8 "GO:0003779,GO:0005515,GO:0005886,GO:0005938,GO:0007266,GO:0008360,GO:0010458,GO:0016601,GO:0030426,GO:0030832,GO:0031267,GO:0031982,GO:0032420,GO:0032587,GO:0035023,GO:0035591,GO:0036336,GO:0045202,GO:0050790,GO:0051016,GO:0051017,GO:0051764,GO:0070062,GO:0070358,GO:1900029" actin binding|protein binding|plasma membrane|cell cortex|Rho protein signal transduction|regulation of cell shape|exit from mitosis|Rac protein signal transduction|growth cone|regulation of actin filament length|small GTPase binding|vesicle|stereocilium|ruffle membrane|regulation of Rho protein signal transduction|signaling adaptor activity|dendritic cell migration|synapse|regulation of catalytic activity|barbed-end actin filament capping|actin filament bundle assembly|actin crosslink formation|extracellular exosome|actin polymerization-dependent cell motility|positive regulation of ruffle assembly EPS8L1 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.048791719 0.073867564 54869 EPS8 like 1 "GO:0003779,GO:0005085,GO:0005515,GO:0005829,GO:0005886,GO:0007266,GO:0032587,GO:0032991,GO:0035023,GO:0042608,GO:0045296,GO:0050790,GO:0070062,GO:1900029" actin binding|guanyl-nucleotide exchange factor activity|protein binding|cytosol|plasma membrane|Rho protein signal transduction|ruffle membrane|protein-containing complex|regulation of Rho protein signal transduction|T cell receptor binding|cadherin binding|regulation of catalytic activity|extracellular exosome|positive regulation of ruffle assembly EPS8L2 2904.139442 2965.179566 2843.099318 0.958828717 -0.060654977 0.79883696 1 47.54993499 44.8293187 64787 EPS8 like 2 "GO:0003779,GO:0005085,GO:0005515,GO:0005829,GO:0005886,GO:0007266,GO:0007605,GO:0031982,GO:0032421,GO:0032426,GO:0032587,GO:0032991,GO:0035023,GO:0045296,GO:0050790,GO:0070062,GO:1900029" actin binding|guanyl-nucleotide exchange factor activity|protein binding|cytosol|plasma membrane|Rho protein signal transduction|sensory perception of sound|vesicle|stereocilium bundle|stereocilium tip|ruffle membrane|protein-containing complex|regulation of Rho protein signal transduction|cadherin binding|regulation of catalytic activity|extracellular exosome|positive regulation of ruffle assembly EPSTI1 65.09567914 56.18234966 74.00900861 1.317299989 0.397583929 0.475888736 1 0.407218354 0.527452325 94240 epithelial stromal interaction 1 EQTN 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.025377046 0.092206165 54586 equatorin "GO:0002079,GO:0002081,GO:0005886,GO:0006897,GO:0007342,GO:0016021,GO:0060478" inner acrosomal membrane|outer acrosomal membrane|plasma membrane|endocytosis|fusion of sperm to egg plasma membrane involved in single fertilization|integral component of membrane|acrosomal vesicle exocytosis ERAL1 1067.877138 1111.162027 1024.592249 0.92209077 -0.117019319 0.634257589 1 32.26369703 29.25223032 26284 Era like 12S mitochondrial rRNA chaperone 1 "GO:0000028,GO:0003723,GO:0005515,GO:0005525,GO:0005739,GO:0005743,GO:0005759,GO:0005829,GO:0019843,GO:0043024,GO:0070125,GO:0070126" ribosomal small subunit assembly|RNA binding|protein binding|GTP binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|cytosol|rRNA binding|ribosomal small subunit binding|mitochondrial translational elongation|mitochondrial translational termination ERAP1 1726.912593 1998.635069 1455.190117 0.728091956 -0.457807424 0.053840681 1 10.81670016 7.743765678 51752 endoplasmic reticulum aminopeptidase 1 "GO:0001525,GO:0002250,GO:0002474,GO:0004177,GO:0005138,GO:0005151,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005783,GO:0005788,GO:0005789,GO:0005829,GO:0005886,GO:0006508,GO:0006509,GO:0007165,GO:0008217,GO:0008235,GO:0008270,GO:0009617,GO:0016020,GO:0016021,GO:0019885,GO:0042277,GO:0043171,GO:0045088,GO:0045444,GO:0070006,GO:0070062" "angiogenesis|adaptive immune response|antigen processing and presentation of peptide antigen via MHC class I|aminopeptidase activity|interleukin-6 receptor binding|interleukin-1, type II receptor binding|protein binding|extracellular region|extracellular space|cytoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|cytosol|plasma membrane|proteolysis|membrane protein ectodomain proteolysis|signal transduction|regulation of blood pressure|metalloexopeptidase activity|zinc ion binding|response to bacterium|membrane|integral component of membrane|antigen processing and presentation of endogenous peptide antigen via MHC class I|peptide binding|peptide catabolic process|regulation of innate immune response|fat cell differentiation|metalloaminopeptidase activity|extracellular exosome" ERAP2 161.6019196 179.9916017 143.2122374 0.795660665 -0.329774817 0.406962371 1 1.687600311 1.320287962 64167 endoplasmic reticulum aminopeptidase 2 "GO:0002250,GO:0002474,GO:0004177,GO:0005737,GO:0005788,GO:0005789,GO:0005886,GO:0006508,GO:0007165,GO:0008217,GO:0008237,GO:0008270,GO:0016021,GO:0019885,GO:0042277,GO:0043171,GO:0070006" adaptive immune response|antigen processing and presentation of peptide antigen via MHC class I|aminopeptidase activity|cytoplasm|endoplasmic reticulum lumen|endoplasmic reticulum membrane|plasma membrane|proteolysis|signal transduction|regulation of blood pressure|metallopeptidase activity|zinc ion binding|integral component of membrane|antigen processing and presentation of endogenous peptide antigen via MHC class I|peptide binding|peptide catabolic process|metalloaminopeptidase activity ERBB2 1825.813506 1844.653814 1806.973197 0.979573069 -0.029774984 0.902319822 1 16.39123938 15.78773427 2064 erb-b2 receptor tyrosine kinase 2 "GO:0000165,GO:0001042,GO:0001934,GO:0004713,GO:0004714,GO:0004888,GO:0005515,GO:0005524,GO:0005634,GO:0005769,GO:0005829,GO:0005886,GO:0005887,GO:0006357,GO:0006468,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007275,GO:0007422,GO:0007507,GO:0007528,GO:0008022,GO:0008045,GO:0008284,GO:0009925,GO:0010008,GO:0014065,GO:0016021,GO:0016323,GO:0016324,GO:0018108,GO:0019838,GO:0019903,GO:0030182,GO:0030307,GO:0032886,GO:0033088,GO:0033674,GO:0035556,GO:0038128,GO:0038143,GO:0042060,GO:0042552,GO:0042802,GO:0043125,GO:0043209,GO:0043235,GO:0043406,GO:0043410,GO:0043547,GO:0045727,GO:0045765,GO:0045785,GO:0045943,GO:0046777,GO:0046982,GO:0048471,GO:0048709,GO:0050679,GO:0051897,GO:0070372,GO:0071363,GO:0071364,GO:0090314,GO:1901185,GO:2000145" MAPK cascade|RNA polymerase I core binding|positive regulation of protein phosphorylation|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|transmembrane signaling receptor activity|protein binding|ATP binding|nucleus|early endosome|cytosol|plasma membrane|integral component of plasma membrane|regulation of transcription by RNA polymerase II|protein phosphorylation|signal transduction|cell surface receptor signaling pathway|enzyme linked receptor protein signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|peripheral nervous system development|heart development|neuromuscular junction development|protein C-terminus binding|motor neuron axon guidance|positive regulation of cell population proliferation|basal plasma membrane|endosome membrane|phosphatidylinositol 3-kinase signaling|integral component of membrane|basolateral plasma membrane|apical plasma membrane|peptidyl-tyrosine phosphorylation|growth factor binding|protein phosphatase binding|neuron differentiation|positive regulation of cell growth|regulation of microtubule-based process|negative regulation of immature T cell proliferation in thymus|positive regulation of kinase activity|intracellular signal transduction|ERBB2 signaling pathway|ERBB3:ERBB2 complex|wound healing|myelination|identical protein binding|ErbB-3 class receptor binding|myelin sheath|receptor complex|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|positive regulation of GTPase activity|positive regulation of translation|regulation of angiogenesis|positive regulation of cell adhesion|positive regulation of transcription by RNA polymerase I|protein autophosphorylation|protein heterodimerization activity|perinuclear region of cytoplasm|oligodendrocyte differentiation|positive regulation of epithelial cell proliferation|positive regulation of protein kinase B signaling|regulation of ERK1 and ERK2 cascade|cellular response to growth factor stimulus|cellular response to epidermal growth factor stimulus|positive regulation of protein targeting to membrane|negative regulation of ERBB signaling pathway|regulation of cell motility "hsa01521,hsa01522,hsa01524,hsa04010,hsa04012,hsa04020,hsa04066,hsa04151,hsa04510,hsa04520,hsa04530,hsa05200,hsa05205,hsa05206,hsa05212,hsa05213,hsa05215,hsa05219,hsa05223,hsa05224,hsa05226,hsa05230" EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|ErbB signaling pathway|Calcium signaling pathway|HIF-1 signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Adherens junction|Tight junction|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Pancreatic cancer|Endometrial cancer|Prostate cancer|Bladder cancer|Non-small cell lung cancer|Breast cancer|Gastric cancer|Central carbon metabolism in cancer ERBB3 719.7480249 689.7944042 749.7016457 1.086847967 0.120150144 0.641054945 1 6.490313745 6.935945423 2065 erb-b2 receptor tyrosine kinase 3 "GO:0000165,GO:0003197,GO:0004713,GO:0004714,GO:0004888,GO:0005515,GO:0005524,GO:0005615,GO:0005886,GO:0005887,GO:0007162,GO:0007165,GO:0007169,GO:0007275,GO:0007399,GO:0007422,GO:0007507,GO:0008284,GO:0009925,GO:0009968,GO:0010628,GO:0014037,GO:0014065,GO:0014068,GO:0016323,GO:0016324,GO:0016328,GO:0018108,GO:0019838,GO:0021545,GO:0030296,GO:0031625,GO:0033674,GO:0038128,GO:0038131,GO:0038132,GO:0038143,GO:0042060,GO:0042127,GO:0042802,GO:0043125,GO:0043235,GO:0043524,GO:0046982,GO:0051048,GO:0051402,GO:0051897,GO:0055025,GO:0061098,GO:0070886,GO:0097192,GO:2000145" MAPK cascade|endocardial cushion development|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|transmembrane signaling receptor activity|protein binding|ATP binding|extracellular space|plasma membrane|integral component of plasma membrane|negative regulation of cell adhesion|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|nervous system development|peripheral nervous system development|heart development|positive regulation of cell population proliferation|basal plasma membrane|negative regulation of signal transduction|positive regulation of gene expression|Schwann cell differentiation|phosphatidylinositol 3-kinase signaling|positive regulation of phosphatidylinositol 3-kinase signaling|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|peptidyl-tyrosine phosphorylation|growth factor binding|cranial nerve development|protein tyrosine kinase activator activity|ubiquitin protein ligase binding|positive regulation of kinase activity|ERBB2 signaling pathway|neuregulin receptor activity|neuregulin binding|ERBB3:ERBB2 complex|wound healing|regulation of cell population proliferation|identical protein binding|ErbB-3 class receptor binding|receptor complex|negative regulation of neuron apoptotic process|protein heterodimerization activity|negative regulation of secretion|neuron apoptotic process|positive regulation of protein kinase B signaling|positive regulation of cardiac muscle tissue development|positive regulation of protein tyrosine kinase activity|positive regulation of calcineurin-NFAT signaling cascade|extrinsic apoptotic signaling pathway in absence of ligand|regulation of cell motility "hsa01521,hsa04010,hsa04012,hsa04020,hsa04151,hsa05205,hsa05206" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|ErbB signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Proteoglycans in cancer|MicroRNAs in cancer ERBB4 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.008990443 0.012249864 2066 erb-b2 receptor tyrosine kinase 4 "GO:0000165,GO:0000976,GO:0001755,GO:0001934,GO:0004713,GO:0004714,GO:0005154,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0005887,GO:0007165,GO:0007169,GO:0007275,GO:0007399,GO:0007416,GO:0007507,GO:0007595,GO:0008284,GO:0008285,GO:0009880,GO:0009925,GO:0014068,GO:0016323,GO:0016477,GO:0018108,GO:0021551,GO:0021889,GO:0030334,GO:0033674,GO:0038128,GO:0042531,GO:0042803,GO:0043235,GO:0043653,GO:0045165,GO:0045211,GO:0045893,GO:0046427,GO:0046777,GO:0051897,GO:0060045,GO:0060644,GO:0060749,GO:0061026,GO:0070374,GO:0071364,GO:0098978,GO:0098982,GO:0099056,GO:0099061,GO:2000010,GO:2000145,GO:2001223" "MAPK cascade|transcription regulatory region sequence-specific DNA binding|neural crest cell migration|positive regulation of protein phosphorylation|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|epidermal growth factor receptor binding|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|plasma membrane|integral component of plasma membrane|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|nervous system development|synapse assembly|heart development|lactation|positive regulation of cell population proliferation|negative regulation of cell population proliferation|embryonic pattern specification|basal plasma membrane|positive regulation of phosphatidylinositol 3-kinase signaling|basolateral plasma membrane|cell migration|peptidyl-tyrosine phosphorylation|central nervous system morphogenesis|olfactory bulb interneuron differentiation|regulation of cell migration|positive regulation of kinase activity|ERBB2 signaling pathway|positive regulation of tyrosine phosphorylation of STAT protein|protein homodimerization activity|receptor complex|mitochondrial fragmentation involved in apoptotic process|cell fate commitment|postsynaptic membrane|positive regulation of transcription, DNA-templated|positive regulation of receptor signaling pathway via JAK-STAT|protein autophosphorylation|positive regulation of protein kinase B signaling|positive regulation of cardiac muscle cell proliferation|mammary gland epithelial cell differentiation|mammary gland alveolus development|cardiac muscle tissue regeneration|positive regulation of ERK1 and ERK2 cascade|cellular response to epidermal growth factor stimulus|glutamatergic synapse|GABA-ergic synapse|integral component of presynaptic membrane|integral component of postsynaptic density membrane|positive regulation of protein localization to cell surface|regulation of cell motility|negative regulation of neuron migration" "hsa04010,hsa04012,hsa04020,hsa04151,hsa05014,hsa05205" MAPK signaling pathway|ErbB signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Amyotrophic lateral sclerosis|Proteoglycans in cancer ERBIN 4401.112963 4125.241045 4676.984882 1.133748266 0.181100344 0.448512401 1 29.73480992 33.14766806 55914 erbb2 interacting protein "GO:0005102,GO:0005176,GO:0005200,GO:0005515,GO:0005604,GO:0005634,GO:0005737,GO:0005886,GO:0006605,GO:0007155,GO:0007165,GO:0007173,GO:0007229,GO:0009925,GO:0016323,GO:0016607,GO:0030054,GO:0030056,GO:0031965,GO:0032088,GO:0032495,GO:0032496,GO:0038128,GO:0045104,GO:0045175,GO:0045197,GO:0046579,GO:0070433,GO:0071356,GO:0071638,GO:0098794,GO:0098978,GO:0099072" signaling receptor binding|ErbB-2 class receptor binding|structural constituent of cytoskeleton|protein binding|basement membrane|nucleus|cytoplasm|plasma membrane|protein targeting|cell adhesion|signal transduction|epidermal growth factor receptor signaling pathway|integrin-mediated signaling pathway|basal plasma membrane|basolateral plasma membrane|nuclear speck|cell junction|hemidesmosome|nuclear membrane|negative regulation of NF-kappaB transcription factor activity|response to muramyl dipeptide|response to lipopolysaccharide|ERBB2 signaling pathway|intermediate filament cytoskeleton organization|basal protein localization|establishment or maintenance of epithelial cell apical/basal polarity|positive regulation of Ras protein signal transduction|negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|cellular response to tumor necrosis factor|negative regulation of monocyte chemotactic protein-1 production|postsynapse|glutamatergic synapse|regulation of postsynaptic membrane neurotransmitter receptor levels hsa04621 NOD-like receptor signaling pathway ERC1 1669.224343 1846.734642 1491.714044 0.807757655 -0.308005577 0.194874265 1 12.82457172 10.1857997 23085 ELKS/RAB6-interacting/CAST family member 1 "GO:0000139,GO:0005515,GO:0005737,GO:0005813,GO:0006355,GO:0007252,GO:0007275,GO:0008385,GO:0015031,GO:0030165,GO:0031267,GO:0036064,GO:0042147,GO:0042734,GO:0043066,GO:0043522,GO:0045202,GO:0045296,GO:0051092" "Golgi membrane|protein binding|cytoplasm|centrosome|regulation of transcription, DNA-templated|I-kappaB phosphorylation|multicellular organism development|IkappaB kinase complex|protein transport|PDZ domain binding|small GTPase binding|ciliary basal body|retrograde transport, endosome to Golgi|presynaptic membrane|negative regulation of apoptotic process|leucine zipper domain binding|synapse|cadherin binding|positive regulation of NF-kappaB transcription factor activity" hsa04064 NF-kappa B signaling pathway ERCC1 2009.543363 1772.865256 2246.221469 1.267000671 0.341417289 0.149105812 1 19.8686603 24.75235972 2067 "ERCC excision repair 1, endonuclease non-catalytic subunit" "GO:0000014,GO:0000109,GO:0000110,GO:0000710,GO:0000720,GO:0000781,GO:0001094,GO:0003677,GO:0003684,GO:0003697,GO:0005515,GO:0005654,GO:0005737,GO:0006281,GO:0006283,GO:0006289,GO:0006293,GO:0006295,GO:0006296,GO:0006303,GO:0006310,GO:0006312,GO:0006949,GO:0006979,GO:0007283,GO:0007584,GO:0008022,GO:0008283,GO:0008584,GO:0009650,GO:0009744,GO:0010165,GO:0010259,GO:0019904,GO:0032205,GO:0033683,GO:0035166,GO:0035264,GO:0035902,GO:0036297,GO:0045190,GO:0046686,GO:0048477,GO:0048568,GO:0060261,GO:0061819,GO:0070522,GO:0070911,GO:0070914,GO:0090399,GO:0090656,GO:1904431,GO:1905765,GO:1990599,GO:1990841" "single-stranded DNA endodeoxyribonuclease activity|nucleotide-excision repair complex|nucleotide-excision repair factor 1 complex|meiotic mismatch repair|pyrimidine dimer repair by nucleotide-excision repair|chromosome, telomeric region|TFIID-class transcription factor complex binding|DNA binding|damaged DNA binding|single-stranded DNA binding|protein binding|nucleoplasm|cytoplasm|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|double-strand break repair via nonhomologous end joining|DNA recombination|mitotic recombination|syncytium formation|response to oxidative stress|spermatogenesis|response to nutrient|protein C-terminus binding|cell population proliferation|male gonad development|UV protection|response to sucrose|response to X-ray|multicellular organism aging|protein domain specific binding|negative regulation of telomere maintenance|nucleotide-excision repair, DNA incision|post-embryonic hemopoiesis|multicellular organism growth|response to immobilization stress|interstrand cross-link repair|isotype switching|response to cadmium ion|oogenesis|embryonic organ development|positive regulation of transcription initiation from RNA polymerase II promoter|telomeric DNA-containing double minutes formation|ERCC4-ERCC1 complex|global genome nucleotide-excision repair|UV-damage excision repair|replicative senescence|t-circle formation|positive regulation of t-circle formation|negative regulation of protection from non-homologous end joining at telomere|3' overhang single-stranded DNA endodeoxyribonuclease activity|promoter-specific chromatin binding" "hsa01524,hsa03420,hsa03460" Platinum drug resistance|Nucleotide excision repair|Fanconi anemia pathway ERCC2 3279.068908 3068.18054 3489.957276 1.137468031 0.185825998 0.433324504 1 36.05089307 40.32054611 2068 "ERCC excision repair 2, TFIIH core complex helicase subunit" "GO:0000439,GO:0000462,GO:0000717,GO:0001666,GO:0001701,GO:0003678,GO:0003684,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005669,GO:0005675,GO:0005737,GO:0005819,GO:0005829,GO:0006283,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006915,GO:0006979,GO:0007059,GO:0007568,GO:0008022,GO:0008283,GO:0009411,GO:0009650,GO:0009791,GO:0016032,GO:0021510,GO:0030198,GO:0030282,GO:0030674,GO:0032289,GO:0033683,GO:0035264,GO:0035315,GO:0040016,GO:0043139,GO:0043249,GO:0043388,GO:0045951,GO:0046872,GO:0047485,GO:0048568,GO:0048820,GO:0051539,GO:0060218,GO:0070516,GO:0070911,GO:0071817,GO:1901990" "transcription factor TFIIH core complex|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nucleotide-excision repair, DNA duplex unwinding|response to hypoxia|in utero embryonic development|DNA helicase activity|damaged DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIH holo complex|cytoplasm|spindle|cytosol|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|apoptotic process|response to oxidative stress|chromosome segregation|aging|protein C-terminus binding|cell population proliferation|response to UV|UV protection|post-embryonic development|viral process|spinal cord development|extracellular matrix organization|bone mineralization|protein-macromolecule adaptor activity|central nervous system myelin formation|nucleotide-excision repair, DNA incision|multicellular organism growth|hair cell differentiation|embryonic cleavage|5'-3' DNA helicase activity|erythrocyte maturation|positive regulation of DNA binding|positive regulation of mitotic recombination|metal ion binding|protein N-terminus binding|embryonic organ development|hair follicle maturation|4 iron, 4 sulfur cluster binding|hematopoietic stem cell differentiation|CAK-ERCC2 complex|global genome nucleotide-excision repair|MMXD complex|regulation of mitotic cell cycle phase transition" "hsa03022,hsa03420" Basal transcription factors|Nucleotide excision repair ERCC3 1689.815583 1731.248701 1648.382465 0.95213499 -0.070761967 0.767657397 1 31.03579485 29.05578253 2071 "ERCC excision repair 3, TFIIH core complex helicase subunit" "GO:0000112,GO:0000439,GO:0000717,GO:0003677,GO:0003684,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005669,GO:0005675,GO:0006265,GO:0006281,GO:0006283,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006915,GO:0006979,GO:0008022,GO:0008104,GO:0008134,GO:0009411,GO:0016032,GO:0016887,GO:0033683,GO:0035315,GO:0043065,GO:0043138,GO:0047485,GO:0048568,GO:0070911,GO:0097550,GO:1901990" "nucleotide-excision repair factor 3 complex|transcription factor TFIIH core complex|nucleotide-excision repair, DNA duplex unwinding|DNA binding|damaged DNA binding|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIH holo complex|DNA topological change|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|apoptotic process|response to oxidative stress|protein C-terminus binding|protein localization|transcription factor binding|response to UV|viral process|ATPase activity|nucleotide-excision repair, DNA incision|hair cell differentiation|positive regulation of apoptotic process|3'-5' DNA helicase activity|protein N-terminus binding|embryonic organ development|global genome nucleotide-excision repair|transcription preinitiation complex|regulation of mitotic cell cycle phase transition" "hsa03022,hsa03420" Basal transcription factors|Nucleotide excision repair ERCC4 319.7655658 345.417409 294.1137225 0.851473362 -0.231966699 0.455364415 1 2.565306467 2.147738984 2072 "ERCC excision repair 4, endonuclease catalytic subunit" "GO:0000014,GO:0000109,GO:0000110,GO:0000712,GO:0000723,GO:0000724,GO:0000781,GO:0001094,GO:0003677,GO:0003684,GO:0003697,GO:0004520,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006283,GO:0006289,GO:0006293,GO:0006295,GO:0006296,GO:0006303,GO:0008022,GO:0009411,GO:0009650,GO:0010506,GO:0010521,GO:0032205,GO:0033683,GO:0034644,GO:0036297,GO:0042802,GO:0047485,GO:0051974,GO:0061819,GO:0070522,GO:0070911,GO:1901255,GO:1904357,GO:1905765,GO:1905768,GO:1990599,GO:1990841" "single-stranded DNA endodeoxyribonuclease activity|nucleotide-excision repair complex|nucleotide-excision repair factor 1 complex|resolution of meiotic recombination intermediates|telomere maintenance|double-strand break repair via homologous recombination|chromosome, telomeric region|TFIID-class transcription factor complex binding|DNA binding|damaged DNA binding|single-stranded DNA binding|endodeoxyribonuclease activity|protein binding|nucleus|nucleoplasm|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|double-strand break repair via nonhomologous end joining|protein C-terminus binding|response to UV|UV protection|regulation of autophagy|telomerase inhibitor activity|negative regulation of telomere maintenance|nucleotide-excision repair, DNA incision|cellular response to UV|interstrand cross-link repair|identical protein binding|protein N-terminus binding|negative regulation of telomerase activity|telomeric DNA-containing double minutes formation|ERCC4-ERCC1 complex|global genome nucleotide-excision repair|nucleotide-excision repair involved in interstrand cross-link repair|negative regulation of telomere maintenance via telomere lengthening|negative regulation of protection from non-homologous end joining at telomere|negative regulation of double-stranded telomeric DNA binding|3' overhang single-stranded DNA endodeoxyribonuclease activity|promoter-specific chromatin binding" "hsa03420,hsa03460" Nucleotide excision repair|Fanconi anemia pathway ERCC5 47.24006644 41.61655531 52.86357758 1.270253561 0.345116509 0.591397975 1 0.571244616 0.713483148 2073 "ERCC excision repair 5, endonuclease" "GO:0000109,GO:0000405,GO:0000993,GO:0003690,GO:0003697,GO:0004520,GO:0005515,GO:0005634,GO:0005654,GO:0005662,GO:0006283,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0009411,GO:0009650,GO:0010225,GO:0033683,GO:0042803,GO:0043066,GO:0044877,GO:0046872,GO:0047485" "nucleotide-excision repair complex|bubble DNA binding|RNA polymerase II complex binding|double-stranded DNA binding|single-stranded DNA binding|endodeoxyribonuclease activity|protein binding|nucleus|nucleoplasm|DNA replication factor A complex|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|response to UV|UV protection|response to UV-C|nucleotide-excision repair, DNA incision|protein homodimerization activity|negative regulation of apoptotic process|protein-containing complex binding|metal ion binding|protein N-terminus binding" hsa03420 Nucleotide excision repair ERCC6 271.8172084 272.5884373 271.0459796 0.994341441 -0.008186759 0.992841083 1 0.475083893 0.464490703 2074 "ERCC excision repair 6, chromatin remodeling factor" "GO:0000012,GO:0000077,GO:0000303,GO:0003677,GO:0003678,GO:0003682,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006283,GO:0006284,GO:0006290,GO:0006362,GO:0006366,GO:0006979,GO:0007256,GO:0007257,GO:0008022,GO:0008023,GO:0008094,GO:0008630,GO:0009411,GO:0009636,GO:0010165,GO:0010224,GO:0010332,GO:0022008,GO:0030182,GO:0030296,GO:0031175,GO:0032508,GO:0032784,GO:0032786,GO:0035264,GO:0043044,GO:0043565,GO:0044877,GO:0045494,GO:0045739,GO:0045815,GO:0047485,GO:0060261,GO:0061098,GO:0090734,GO:0097680,GO:1905168,GO:2001033" "single strand break repair|DNA damage checkpoint|response to superoxide|DNA binding|DNA helicase activity|chromatin binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|transcription-coupled nucleotide-excision repair|base-excision repair|pyrimidine dimer repair|transcription elongation from RNA polymerase I promoter|transcription by RNA polymerase II|response to oxidative stress|activation of JNKK activity|activation of JUN kinase activity|protein C-terminus binding|transcription elongation factor complex|DNA-dependent ATPase activity|intrinsic apoptotic signaling pathway in response to DNA damage|response to UV|response to toxic substance|response to X-ray|response to UV-B|response to gamma radiation|neurogenesis|neuron differentiation|protein tyrosine kinase activator activity|neuron projection development|DNA duplex unwinding|regulation of DNA-templated transcription, elongation|positive regulation of DNA-templated transcription, elongation|multicellular organism growth|ATP-dependent chromatin remodeling|sequence-specific DNA binding|protein-containing complex binding|photoreceptor cell maintenance|positive regulation of DNA repair|positive regulation of gene expression, epigenetic|protein N-terminus binding|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of protein tyrosine kinase activity|site of DNA damage|double-strand break repair via classical nonhomologous end joining|positive regulation of double-strand break repair via homologous recombination|negative regulation of double-strand break repair via nonhomologous end joining" hsa03420 Nucleotide excision repair ERCC6L 973.8781973 927.0087694 1020.747625 1.101119708 0.138971319 0.57481738 1 11.40976805 12.35328696 54821 "ERCC excision repair 6 like, spindle assembly checkpoint helicase" "GO:0000777,GO:0003677,GO:0003678,GO:0005515,GO:0005524,GO:0005829,GO:0007049,GO:0015616,GO:0016020,GO:0032508,GO:0051301" condensed chromosome kinetochore|DNA binding|DNA helicase activity|protein binding|ATP binding|cytosol|cell cycle|DNA translocase activity|membrane|DNA duplex unwinding|cell division ERCC6L2 496.1760839 548.2981162 444.0540517 0.809877033 -0.30422522 0.267006654 1 2.264308808 1.803125345 375748 ERCC excision repair 6 like 2 "GO:0003677,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005813,GO:0019901,GO:0032991,GO:0034614,GO:0036297" DNA binding|helicase activity|protein binding|ATP binding|nucleus|cytoplasm|mitochondrion|centrosome|protein kinase binding|protein-containing complex|cellular response to reactive oxygen species|interstrand cross-link repair ERCC8 366.7382903 354.781134 378.6954467 1.067405818 0.094108781 0.75821044 1 1.908671075 2.003234709 1161 "ERCC excision repair 8, CSA ubiquitin ligase complex subunit" "GO:0000012,GO:0000109,GO:0000209,GO:0003678,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006283,GO:0006289,GO:0006974,GO:0006979,GO:0008094,GO:0009411,GO:0010165,GO:0010996,GO:0014070,GO:0016363,GO:0031464,GO:0032508,GO:0032991,GO:0043161,GO:0043204,GO:0043687,GO:0044877,GO:0045739,GO:0051865,GO:0080008,GO:0097680" single strand break repair|nucleotide-excision repair complex|protein polyubiquitination|DNA helicase activity|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|cellular response to DNA damage stimulus|response to oxidative stress|DNA-dependent ATPase activity|response to UV|response to X-ray|response to auditory stimulus|response to organic cyclic compound|nuclear matrix|Cul4A-RING E3 ubiquitin ligase complex|DNA duplex unwinding|protein-containing complex|proteasome-mediated ubiquitin-dependent protein catabolic process|perikaryon|post-translational protein modification|protein-containing complex binding|positive regulation of DNA repair|protein autoubiquitination|Cul4-RING E3 ubiquitin ligase complex|double-strand break repair via classical nonhomologous end joining "hsa03420,hsa04120" Nucleotide excision repair|Ubiquitin mediated proteolysis other EREG 1979.735624 2100.595629 1858.875619 0.884927871 -0.176368226 0.456604731 1 24.29142535 21.13645022 2069 epiregulin "GO:0000165,GO:0001525,GO:0001550,GO:0001556,GO:0001819,GO:0005154,GO:0005515,GO:0005576,GO:0005615,GO:0005887,GO:0007143,GO:0007165,GO:0007173,GO:0007267,GO:0008083,GO:0008284,GO:0008285,GO:0009299,GO:0009653,GO:0009887,GO:0019221,GO:0030216,GO:0030665,GO:0030728,GO:0032755,GO:0038128,GO:0042059,GO:0042060,GO:0042327,GO:0042700,GO:0043434,GO:0043616,GO:0045089,GO:0045740,GO:0045741,GO:0045840,GO:0045860,GO:0045892,GO:0048146,GO:0048160,GO:0048661,GO:0050680,GO:0051151,GO:0051781,GO:0051897,GO:0061024,GO:2000145" "MAPK cascade|angiogenesis|ovarian cumulus expansion|oocyte maturation|positive regulation of cytokine production|epidermal growth factor receptor binding|protein binding|extracellular region|extracellular space|integral component of plasma membrane|female meiotic nuclear division|signal transduction|epidermal growth factor receptor signaling pathway|cell-cell signaling|growth factor activity|positive regulation of cell population proliferation|negative regulation of cell population proliferation|mRNA transcription|anatomical structure morphogenesis|animal organ morphogenesis|cytokine-mediated signaling pathway|keratinocyte differentiation|clathrin-coated vesicle membrane|ovulation|positive regulation of interleukin-6 production|ERBB2 signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|wound healing|positive regulation of phosphorylation|luteinizing hormone signaling pathway|response to peptide hormone|keratinocyte proliferation|positive regulation of innate immune response|positive regulation of DNA replication|positive regulation of epidermal growth factor-activated receptor activity|positive regulation of mitotic nuclear division|positive regulation of protein kinase activity|negative regulation of transcription, DNA-templated|positive regulation of fibroblast proliferation|primary follicle stage|positive regulation of smooth muscle cell proliferation|negative regulation of epithelial cell proliferation|negative regulation of smooth muscle cell differentiation|positive regulation of cell division|positive regulation of protein kinase B signaling|membrane organization|regulation of cell motility" "hsa04010,hsa04012,hsa04151,hsa05210" MAPK signaling pathway|ErbB signaling pathway|PI3K-Akt signaling pathway|Colorectal cancer ERF 893.809759 957.180772 830.438746 0.867588203 -0.204917659 0.410611506 1 16.3937672 13.98503573 2077 ETS2 repressor factor "GO:0000122,GO:0000785,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0030154,GO:0043565" "negative regulation of transcription by RNA polymerase II|chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|cell differentiation|sequence-specific DNA binding" ETS ERFE 470.1751833 572.2276355 368.1227311 0.643315192 -0.636402336 0.021737806 0.822216713 10.39085988 6.572740325 151176 erythroferrone "GO:0005179,GO:0005576,GO:0005615,GO:0006879,GO:0007165,GO:0019217,GO:0045721,GO:0046326,GO:0046628,GO:2000193" hormone activity|extracellular region|extracellular space|cellular iron ion homeostasis|signal transduction|regulation of fatty acid metabolic process|negative regulation of gluconeogenesis|positive regulation of glucose import|positive regulation of insulin receptor signaling pathway|positive regulation of fatty acid transport ERFL 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.049910091 0.068004637 390937 ETS repressor factor like "GO:0000981,GO:0005634,GO:0006357,GO:0030154,GO:0043565" "DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|cell differentiation|sequence-specific DNA binding" ERG28 612.2029679 629.450399 594.9555368 0.945198442 -0.081310843 0.761231595 1 14.47957367 13.45705263 11161 ergosterol biosynthesis 28 homolog "GO:0003674,GO:0005515,GO:0005783,GO:0005789,GO:0008150,GO:0016021,GO:0016126,GO:0030133,GO:0030674,GO:0042802" molecular_function|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|biological_process|integral component of membrane|sterol biosynthetic process|transport vesicle|protein-macromolecule adaptor activity|identical protein binding ERGIC1 8082.587457 8282.73492 7882.439995 0.951671166 -0.071464935 0.772522528 1 102.583973 95.99256675 57222 endoplasmic reticulum-golgi intermediate compartment 1 "GO:0005515,GO:0005654,GO:0005783,GO:0005793,GO:0006888,GO:0006890,GO:0016020,GO:0030134,GO:0030173,GO:0030176,GO:0033116,GO:0043231" "protein binding|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|membrane|COPII-coated ER to Golgi transport vesicle|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|intracellular membrane-bounded organelle" ERGIC2 1299.708838 1128.849063 1470.568613 1.302715005 0.3815215 0.112963836 1 10.05249453 12.87639942 51290 ERGIC and golgi 2 "GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0006888,GO:0006890,GO:0016020,GO:0016021,GO:0030134,GO:0033116,GO:0043231" "protein binding|nucleus|nucleolus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|membrane|integral component of membrane|COPII-coated ER to Golgi transport vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|intracellular membrane-bounded organelle" ERGIC3 4176.826472 4166.8576 4186.795344 1.004784839 0.006886602 0.978081771 1 168.8515807 166.8204863 51614 ERGIC and golgi 3 "GO:0005515,GO:0005783,GO:0006888,GO:0006890,GO:0016020,GO:0030134,GO:0030173,GO:0030176,GO:0033116" "protein binding|endoplasmic reticulum|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|membrane|COPII-coated ER to Golgi transport vesicle|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment membrane" ERH 2049.340787 1997.594655 2101.08692 1.051808441 0.07287198 0.759570272 1 134.7761761 139.3865795 2079 ERH mRNA splicing and mitosis factor "GO:0003723,GO:0005515,GO:0005634,GO:0006139,GO:0006213,GO:0007049,GO:0008327,GO:0030496,GO:0034709" RNA binding|protein binding|nucleus|nucleobase-containing compound metabolic process|pyrimidine nucleoside metabolic process|cell cycle|methyl-CpG binding|midbody|methylosome ERI1 742.2408407 725.1684762 759.3132052 1.047085236 0.066378887 0.798448266 1 4.595215955 4.731067462 90459 exoribonuclease 1 "GO:0000175,GO:0000467,GO:0000738,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0008408,GO:0019843,GO:0031047,GO:0031125,GO:0043022,GO:0046872,GO:0071044,GO:0071204,GO:0071207" "3'-5'-exoribonuclease activity|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|DNA catabolic process, exonucleolytic|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|rRNA processing|3'-5' exonuclease activity|rRNA binding|gene silencing by RNA|rRNA 3'-end processing|ribosome binding|metal ion binding|histone mRNA catabolic process|histone pre-mRNA 3'end processing complex|histone pre-mRNA stem-loop binding" ERI2 394.3885161 412.0038975 376.7731347 0.914489249 -0.128961886 0.662500318 1 5.227743885 4.700716777 112479 ERI1 exoribonuclease family member 2 "GO:0000175,GO:0000467,GO:0000738,GO:0003676,GO:0008270" "3'-5'-exoribonuclease activity|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|DNA catabolic process, exonucleolytic|nucleic acid binding|zinc ion binding" ERI3 1005.115152 1027.928916 982.301387 0.955612175 -0.065502861 0.793155558 1 31.38368249 29.48877652 79033 ERI1 exoribonuclease family member 3 "GO:0000175,GO:0000467,GO:0000738,GO:0003723,GO:0046872" "3'-5'-exoribonuclease activity|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|DNA catabolic process, exonucleolytic|RNA binding|metal ion binding" ERICH1 410.4803328 430.7313474 390.2293181 0.905969163 -0.14246615 0.624757117 1 0.778703942 0.693676476 157697 glutamate rich 1 GO:0005515 protein binding ERICH2 36.94978409 36.41448589 37.48508228 1.029400289 0.041804092 0.99682426 1 0.628110596 0.635757635 285141 glutamate rich 2 GO:0005515 protein binding ERICH3 2.561405743 4.161655531 0.961155956 0.230955193 -2.11431511 0.482263142 1 0.023271155 0.005284658 127254 glutamate rich 3 ERICH5 110.5719495 101.9605605 119.1833385 1.168916079 0.225171356 0.630224373 1 3.62039103 4.161117613 203111 glutamate rich 5 GO:0005515 protein binding ERICH6 3.443303773 2.080827765 4.80577978 2.309551929 1.207612985 0.648665767 1 0.041685418 0.094663612 131831 glutamate rich 6 ERLEC1 1671.435961 1526.287166 1816.584757 1.19019854 0.251202254 0.290615714 1 12.71743026 14.88298201 27248 endoplasmic reticulum lectin 1 "GO:0005515,GO:0005788,GO:0036503,GO:0044322,GO:0051082,GO:0055085,GO:1904153" "protein binding|endoplasmic reticulum lumen|ERAD pathway|endoplasmic reticulum quality control compartment|unfolded protein binding|transmembrane transport|negative regulation of retrograde protein transport, ER to cytosol" hsa04141 Protein processing in endoplasmic reticulum ERLIN1 4815.134751 4712.034474 4918.235027 1.043760408 0.061790584 0.797190021 1 72.1171837 74.01346836 10613 ER lipid raft associated 1 "GO:0005515,GO:0005783,GO:0005789,GO:0008203,GO:0015485,GO:0016021,GO:0030433,GO:0031625,GO:0032933,GO:0032991,GO:0045541,GO:0045717,GO:0055085" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol metabolic process|cholesterol binding|integral component of membrane|ubiquitin-dependent ERAD pathway|ubiquitin protein ligase binding|SREBP signaling pathway|protein-containing complex|negative regulation of cholesterol biosynthetic process|negative regulation of fatty acid biosynthetic process|transmembrane transport ERLIN2 442.6784429 531.651494 353.7053918 0.665295585 -0.587932635 0.036675212 0.973851514 9.680403651 6.332559614 11160 ER lipid raft associated 2 "GO:0005515,GO:0005783,GO:0005789,GO:0005829,GO:0005886,GO:0008203,GO:0015485,GO:0016021,GO:0030433,GO:0031625,GO:0032933,GO:0032991,GO:0045121,GO:0045541,GO:0045717,GO:0055085" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|plasma membrane|cholesterol metabolic process|cholesterol binding|integral component of membrane|ubiquitin-dependent ERAD pathway|ubiquitin protein ligase binding|SREBP signaling pathway|protein-containing complex|membrane raft|negative regulation of cholesterol biosynthetic process|negative regulation of fatty acid biosynthetic process|transmembrane transport ERMAP 145.3465567 169.5874629 121.1056505 0.714119124 -0.485763341 0.23740682 1 2.391800001 1.679448551 114625 erythroblast membrane associated protein (Scianna blood group) "GO:0001817,GO:0005102,GO:0005515,GO:0005794,GO:0005829,GO:0005886,GO:0009897,GO:0016021,GO:0050852" regulation of cytokine production|signaling receptor binding|protein binding|Golgi apparatus|cytosol|plasma membrane|external side of plasma membrane|integral component of membrane|T cell receptor signaling pathway other ERMARD 214.2076017 223.6889848 204.7262186 0.91522709 -0.127798339 0.728066325 1 3.481443568 3.132992859 55780 ER membrane associated RNA degradation "GO:0003674,GO:0005789,GO:0007275,GO:0008150,GO:0016021" molecular_function|endoplasmic reticulum membrane|multicellular organism development|biological_process|integral component of membrane ERMP1 891.3577937 880.1901447 902.5254427 1.025375537 0.036152385 0.888855795 1 8.51752136 8.587512103 79956 endoplasmic reticulum metallopeptidase 1 "GO:0005515,GO:0005783,GO:0005789,GO:0006508,GO:0008237,GO:0016020,GO:0016021,GO:0030968,GO:0034599,GO:0046872" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|proteolysis|metallopeptidase activity|membrane|integral component of membrane|endoplasmic reticulum unfolded protein response|cellular response to oxidative stress|metal ion binding ERN1 741.5608892 921.8067 561.3150783 0.608929267 -0.71565344 0.00492857 0.428880196 4.51455716 2.703044421 2081 endoplasmic reticulum to nucleus signaling 1 "GO:0000287,GO:0001935,GO:0004521,GO:0004674,GO:0005161,GO:0005515,GO:0005524,GO:0005637,GO:0005737,GO:0005739,GO:0005783,GO:0005789,GO:0006379,GO:0006402,GO:0006468,GO:0007050,GO:0007257,GO:0016241,GO:0019899,GO:0030176,GO:0030544,GO:0033120,GO:0034620,GO:0034976,GO:0035924,GO:0036289,GO:0036498,GO:0042802,GO:0042803,GO:0043531,GO:0046777,GO:0051082,GO:0051879,GO:0070054,GO:0070059,GO:0070301,GO:0071333,GO:0090502,GO:0098787,GO:0106310,GO:0106311,GO:1900103,GO:1901142,GO:1904707,GO:1990332,GO:1990579,GO:1990597,GO:1990604,GO:1990630" "magnesium ion binding|endothelial cell proliferation|endoribonuclease activity|protein serine/threonine kinase activity|platelet-derived growth factor receptor binding|protein binding|ATP binding|nuclear inner membrane|cytoplasm|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|mRNA cleavage|mRNA catabolic process|protein phosphorylation|cell cycle arrest|activation of JUN kinase activity|regulation of macroautophagy|enzyme binding|integral component of endoplasmic reticulum membrane|Hsp70 protein binding|positive regulation of RNA splicing|cellular response to unfolded protein|response to endoplasmic reticulum stress|cellular response to vascular endothelial growth factor stimulus|peptidyl-serine autophosphorylation|IRE1-mediated unfolded protein response|identical protein binding|protein homodimerization activity|ADP binding|protein autophosphorylation|unfolded protein binding|Hsp90 protein binding|mRNA splicing, via endonucleolytic cleavage and ligation|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to hydrogen peroxide|cellular response to glucose stimulus|RNA phosphodiester bond hydrolysis, endonucleolytic|mRNA cleavage involved in mRNA processing|protein serine kinase activity|protein threonine kinase activity|positive regulation of endoplasmic reticulum unfolded protein response|insulin metabolic process|positive regulation of vascular associated smooth muscle cell proliferation|Ire1 complex|peptidyl-serine trans-autophosphorylation|AIP1-IRE1 complex|IRE1-TRAF2-ASK1 complex|IRE1-RACK1-PP2A complex" "hsa04140,hsa04141,hsa04210,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05022" Autophagy - animal|Protein processing in endoplasmic reticulum|Apoptosis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ERO1A 2936.945733 2451.215108 3422.676359 1.396318238 0.481627787 0.042079218 1 23.93282934 32.85864368 30001 endoplasmic reticulum oxidoreductase 1 alpha "GO:0003756,GO:0005515,GO:0005783,GO:0005788,GO:0005789,GO:0006457,GO:0006464,GO:0009266,GO:0010260,GO:0015035,GO:0016020,GO:0016491,GO:0016671,GO:0018215,GO:0018401,GO:0022417,GO:0030198,GO:0030425,GO:0030968,GO:0034599,GO:0034975,GO:0034976,GO:0043231,GO:0045454,GO:0050873,GO:0051085,GO:0051209,GO:0055114,GO:0070059,GO:0071456" "protein disulfide isomerase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|protein folding|cellular protein modification process|response to temperature stimulus|animal organ senescence|protein disulfide oxidoreductase activity|membrane|oxidoreductase activity|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|protein phosphopantetheinylation|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|protein maturation by protein folding|extracellular matrix organization|dendrite|endoplasmic reticulum unfolded protein response|cellular response to oxidative stress|protein folding in endoplasmic reticulum|response to endoplasmic reticulum stress|intracellular membrane-bounded organelle|cell redox homeostasis|brown fat cell differentiation|chaperone cofactor-dependent protein refolding|release of sequestered calcium ion into cytosol|oxidation-reduction process|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to hypoxia" "hsa04141,hsa05110" Protein processing in endoplasmic reticulum|Vibrio cholerae infection ERO1B 528.8113414 458.8225222 598.8001606 1.305080138 0.384138398 0.154743734 1 3.161590024 4.057083174 56605 endoplasmic reticulum oxidoreductase 1 beta "GO:0003756,GO:0005515,GO:0005783,GO:0005789,GO:0006457,GO:0015035,GO:0016491,GO:0016671,GO:0016972,GO:0018215,GO:0034975,GO:0051082,GO:0055114" "protein disulfide isomerase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein folding|protein disulfide oxidoreductase activity|oxidoreductase activity|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|thiol oxidase activity|protein phosphopantetheinylation|protein folding in endoplasmic reticulum|unfolded protein binding|oxidation-reduction process" hsa04141 Protein processing in endoplasmic reticulum ERP29 2651.634671 2669.702023 2633.567319 0.986464893 -0.019660387 0.935389565 1 83.36868944 80.86410548 10961 endoplasmic reticulum protein 29 "GO:0000187,GO:0001934,GO:0003756,GO:0005515,GO:0005783,GO:0005788,GO:0005790,GO:0006457,GO:0006886,GO:0009306,GO:0009986,GO:0010628,GO:0010629,GO:0016020,GO:0018215,GO:0030133,GO:0042470,GO:0042803,GO:0043335,GO:0050709,GO:0051087,GO:1902235" activation of MAPK activity|positive regulation of protein phosphorylation|protein disulfide isomerase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|smooth endoplasmic reticulum|protein folding|intracellular protein transport|protein secretion|cell surface|positive regulation of gene expression|negative regulation of gene expression|membrane|protein phosphopantetheinylation|transport vesicle|melanosome|protein homodimerization activity|protein unfolding|negative regulation of protein secretion|chaperone binding|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway hsa04141 Protein processing in endoplasmic reticulum ERP44 1848.015671 1607.439449 2088.591892 1.299328503 0.377766226 0.11096389 1 17.84236461 22.79515523 23071 endoplasmic reticulum protein 44 "GO:0003756,GO:0005515,GO:0005576,GO:0005788,GO:0005789,GO:0005793,GO:0006457,GO:0006986,GO:0009100,GO:0009986,GO:0018215,GO:0034976,GO:0035580,GO:0043312,GO:0045454,GO:0070062" protein disulfide isomerase activity|protein binding|extracellular region|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|protein folding|response to unfolded protein|glycoprotein metabolic process|cell surface|protein phosphopantetheinylation|response to endoplasmic reticulum stress|specific granule lumen|neutrophil degranulation|cell redox homeostasis|extracellular exosome ERRFI1 5974.091419 5400.788465 6547.394372 1.212303428 0.277750837 0.251410973 1 42.32454539 50.45158492 54206 ERBB receptor feedback inhibitor 1 "GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007175,GO:0017124,GO:0019901,GO:0031234,GO:0031267,GO:0031953,GO:0032691,GO:0032869,GO:0032966,GO:0036120,GO:0042059,GO:0043547,GO:0043589,GO:0045616,GO:0048286,GO:0060426,GO:0060428,GO:0061469,GO:0070373,GO:0071364,GO:0071474,GO:0071549,GO:1903243" GTPase activator activity|protein binding|nucleus|cytoplasm|cytosol|negative regulation of epidermal growth factor-activated receptor activity|SH3 domain binding|protein kinase binding|extrinsic component of cytoplasmic side of plasma membrane|small GTPase binding|negative regulation of protein autophosphorylation|negative regulation of interleukin-1 beta production|cellular response to insulin stimulus|negative regulation of collagen biosynthetic process|cellular response to platelet-derived growth factor stimulus|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of GTPase activity|skin morphogenesis|regulation of keratinocyte differentiation|lung alveolus development|lung vasculature development|lung epithelium development|regulation of type B pancreatic cell proliferation|negative regulation of ERK1 and ERK2 cascade|cellular response to epidermal growth factor stimulus|cellular hyperosmotic response|cellular response to dexamethasone stimulus|negative regulation of cardiac muscle hypertrophy in response to stress ERV3-1 39.42690149 50.98028025 27.87352272 0.546751069 -0.871043959 0.184515426 1 0.848635015 0.456227822 2086 "endogenous retrovirus group 3 member 1, envelope" "GO:0003674,GO:0008150" molecular_function|biological_process ERVFC1 2.561405743 4.161655531 0.961155956 0.230955193 -2.11431511 0.482263142 1 0.067941238 0.015428808 105373297 "GO:0000768,GO:0003674,GO:0005575,GO:0005886,GO:0016021" syncytium formation by plasma membrane fusion|molecular_function|cellular_component|plasma membrane|integral component of membrane ERVMER34-1 10.80545888 18.72744989 2.883467868 0.153970129 -2.699277611 0.025081064 0.861767709 0.267661912 0.040522313 100288413 "endogenous retrovirus group MER34 member 1, envelope" "GO:0005576,GO:0005886,GO:0016021" extracellular region|plasma membrane|integral component of membrane ERVV-2 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.054920847 0.016629335 100271846 "endogenous retrovirus group V member 2, envelope" GO:0016021 integral component of membrane ESAM 36.94978409 36.41448589 37.48508228 1.029400289 0.041804092 0.99682426 1 1.062533726 1.075469722 90952 endothelial cell adhesion molecule "GO:0005515,GO:0005886,GO:0005911,GO:0005912,GO:0005923,GO:0007156,GO:0016021,GO:0030833,GO:0032991,GO:0034613,GO:0035633,GO:0050900,GO:0070830,GO:0098609,GO:0098632,GO:2000249" protein binding|plasma membrane|cell-cell junction|adherens junction|bicellular tight junction|homophilic cell adhesion via plasma membrane adhesion molecules|integral component of membrane|regulation of actin filament polymerization|protein-containing complex|cellular protein localization|maintenance of blood-brain barrier|leukocyte migration|bicellular tight junction assembly|cell-cell adhesion|cell-cell adhesion mediator activity|regulation of actin cytoskeleton reorganization "hsa04514,hsa04670" Cell adhesion molecules|Leukocyte transendothelial migration ESCO1 570.3882678 541.015219 599.7613165 1.108584926 0.148719296 0.57893099 1 6.144496253 6.697711418 114799 establishment of sister chromatid cohesion N-acetyltransferase 1 "GO:0000785,GO:0005654,GO:0005694,GO:0006275,GO:0007062,GO:0008080,GO:0008270,GO:0016407,GO:0018215,GO:0018394,GO:0034421,GO:0061733" chromatin|nucleoplasm|chromosome|regulation of DNA replication|sister chromatid cohesion|N-acetyltransferase activity|zinc ion binding|acetyltransferase activity|protein phosphopantetheinylation|peptidyl-lysine acetylation|post-translational protein acetylation|peptide-lysine-N-acetyltransferase activity ESCO2 356.303969 408.8826559 303.7252821 0.74281772 -0.428919864 0.150968112 1 5.189373567 3.790254475 157570 establishment of sister chromatid cohesion N-acetyltransferase 2 "GO:0000785,GO:0001741,GO:0002244,GO:0004468,GO:0005515,GO:0005654,GO:0005694,GO:0005721,GO:0005794,GO:0006275,GO:0006302,GO:0007062,GO:0010369,GO:0016407,GO:0030054,GO:0034421,GO:0035861,GO:0046872,GO:0071168" "chromatin|XY body|hematopoietic progenitor cell differentiation|lysine N-acetyltransferase activity, acting on acetyl phosphate as donor|protein binding|nucleoplasm|chromosome|pericentric heterochromatin|Golgi apparatus|regulation of DNA replication|double-strand break repair|sister chromatid cohesion|chromocenter|acetyltransferase activity|cell junction|post-translational protein acetylation|site of double-strand break|metal ion binding|protein localization to chromatin" ESD 2394.553063 2203.596603 2585.509522 1.173313445 0.230588474 0.329462147 1 39.95987111 46.10088945 2098 esterase D "GO:0005515,GO:0005788,GO:0005829,GO:0008150,GO:0016788,GO:0018738,GO:0031410,GO:0042802,GO:0046294,GO:0047374,GO:0052689,GO:0070062,GO:1901687" "protein binding|endoplasmic reticulum lumen|cytosol|biological_process|hydrolase activity, acting on ester bonds|S-formylglutathione hydrolase activity|cytoplasmic vesicle|identical protein binding|formaldehyde catabolic process|methylumbelliferyl-acetate deacetylase activity|carboxylic ester hydrolase activity|extracellular exosome|glutathione derivative biosynthetic process" ESF1 498.2273435 526.4494246 470.0052625 0.892783315 -0.16361803 0.553118265 1 5.980340191 5.249804531 51575 ESF1 nucleolar pre-rRNA processing protein homolog "GO:0003723,GO:0005615,GO:0005654,GO:0005730,GO:0006364" RNA binding|extracellular space|nucleoplasm|nucleolus|rRNA processing ESM1 5570.810808 3998.310551 7143.311065 1.786582351 0.837202415 0.000561266 0.133662814 101.804621 178.8387844 11082 endothelial cell specific molecule 1 "GO:0001525,GO:0002040,GO:0005171,GO:0005178,GO:0005515,GO:0005520,GO:0005576,GO:0008284,GO:1902204" angiogenesis|sprouting angiogenesis|hepatocyte growth factor receptor binding|integrin binding|protein binding|insulin-like growth factor binding|extracellular region|positive regulation of cell population proliferation|positive regulation of hepatocyte growth factor receptor signaling pathway ESPL1 1772.800244 2017.362518 1528.23797 0.757542562 -0.400601148 0.091247951 1 15.83744187 11.79677376 9700 "extra spindle pole bodies like 1, separase" "GO:0000070,GO:0000212,GO:0000281,GO:0003824,GO:0004197,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0006508,GO:0006915,GO:0008234,GO:0040001,GO:0045143,GO:0045842,GO:0045875,GO:0051307,GO:0072686" mitotic sister chromatid segregation|meiotic spindle organization|mitotic cytokinesis|catalytic activity|cysteine-type endopeptidase activity|protein binding|nucleus|cytoplasm|centrosome|cytosol|proteolysis|apoptotic process|cysteine-type peptidase activity|establishment of mitotic spindle localization|homologous chromosome segregation|positive regulation of mitotic metaphase/anaphase transition|negative regulation of sister chromatid cohesion|meiotic chromosome separation|mitotic spindle "hsa04110,hsa04114,hsa05166" Cell cycle|Oocyte meiosis|Human T-cell leukemia virus 1 infection ESPNL 24.49941604 24.96993318 24.0288989 0.962313304 -0.055421421 1 1 0.26201326 0.247919644 339768 espin like "GO:0005515,GO:0005737,GO:0007605,GO:0032426,GO:0051015,GO:0051017" protein binding|cytoplasm|sensory perception of sound|stereocilium tip|actin filament binding|actin filament bundle assembly ESR2 10.92937619 9.363724944 12.49502743 1.334407781 0.416199607 0.772652545 1 0.050615293 0.066411227 2100 estrogen receptor 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0003677,GO:0003707,GO:0004879,GO:0005496,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006355,GO:0006357,GO:0006367,GO:0007165,GO:0007267,GO:0008270,GO:0019899,GO:0030284,GO:0030308,GO:0030518,GO:0030520,GO:0034056,GO:0042802,GO:0045893,GO:0048019,GO:0051091,GO:0071392,GO:2000272" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|steroid hormone receptor activity|nuclear receptor activity|steroid binding|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|signal transduction|cell-cell signaling|zinc ion binding|enzyme binding|estrogen receptor activity|negative regulation of cell growth|intracellular steroid hormone receptor signaling pathway|intracellular estrogen receptor signaling pathway|estrogen response element binding|identical protein binding|positive regulation of transcription, DNA-templated|receptor antagonist activity|positive regulation of DNA-binding transcription factor activity|cellular response to estradiol stimulus|negative regulation of signaling receptor activity" "hsa01522,hsa04915,hsa04917,hsa04929,hsa05200,hsa05224" Endocrine resistance|Estrogen signaling pathway|Prolactin signaling pathway|GnRH secretion|Pathways in cancer|Breast cancer ThyrH_rcpt ESRP1 107.8469975 106.122216 109.571779 1.032505568 0.046149562 0.941230034 1 1.440739666 1.462679229 54845 epithelial splicing regulatory protein 1 "GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0006397,GO:0008380,GO:0008543,GO:0016604,GO:0042669,GO:0043484,GO:1990904" RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|mRNA processing|RNA splicing|fibroblast growth factor receptor signaling pathway|nuclear body|regulation of inner ear auditory receptor cell fate specification|regulation of RNA splicing|ribonucleoprotein complex ESRP2 9.125951164 12.48496659 5.766935736 0.461910386 -1.11431511 0.374388992 1 0.098565047 0.044766366 80004 epithelial splicing regulatory protein 2 "GO:0000380,GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0008543,GO:0043484,GO:0050679,GO:0060441,GO:0060445,GO:1990904" "alternative mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|nucleoplasm|fibroblast growth factor receptor signaling pathway|regulation of RNA splicing|positive regulation of epithelial cell proliferation|epithelial tube branching involved in lung morphogenesis|branching involved in salivary gland morphogenesis|ribonucleoprotein complex" ESRRA 822.7640906 858.3414532 787.186728 0.917102075 -0.124845777 0.621304496 1 12.87467841 11.60981354 2101 estrogen related receptor alpha "GO:0000785,GO:0000978,GO:0000981,GO:0001650,GO:0003700,GO:0003707,GO:0004879,GO:0005496,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006357,GO:0006367,GO:0007005,GO:0008270,GO:0015630,GO:0019904,GO:0030522,GO:0043401,GO:0043565,GO:0045171,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|fibrillar center|DNA-binding transcription factor activity|steroid hormone receptor activity|nuclear receptor activity|steroid binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|mitochondrion organization|zinc ion binding|microtubule cytoskeleton|protein domain specific binding|intracellular receptor signaling pathway|steroid hormone mediated signaling pathway|sequence-specific DNA binding|intercellular bridge|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" Retinoic_acid_rcpt ESRRB 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.03363791 0 2103 estrogen related receptor beta "GO:0000785,GO:0000793,GO:0000978,GO:0000981,GO:0000987,GO:0000993,GO:0001228,GO:0001892,GO:0003700,GO:0003707,GO:0004879,GO:0005496,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0006367,GO:0008134,GO:0008270,GO:0017145,GO:0019827,GO:0030522,GO:0032039,GO:0043401,GO:0043565,GO:0043697,GO:0045494,GO:0045725,GO:0045821,GO:0045893,GO:0045944,GO:0048839,GO:0071931,GO:0090282,GO:1902459,GO:1990837,GO:2000035,GO:2000737" "chromatin|condensed chromosome|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|RNA polymerase II complex binding|DNA-binding transcription activator activity, RNA polymerase II-specific|embryonic placenta development|DNA-binding transcription factor activity|steroid hormone receptor activity|nuclear receptor activity|steroid binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription factor binding|zinc ion binding|stem cell division|stem cell population maintenance|intracellular receptor signaling pathway|integrator complex|steroid hormone mediated signaling pathway|sequence-specific DNA binding|cell dedifferentiation|photoreceptor cell maintenance|positive regulation of glycogen biosynthetic process|positive regulation of glycolytic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|inner ear development|positive regulation of transcription involved in G1/S transition of mitotic cell cycle|positive regulation of transcription involved in G2/M transition of mitotic cell cycle|positive regulation of stem cell population maintenance|sequence-specific double-stranded DNA binding|regulation of stem cell division|negative regulation of stem cell differentiation" hsa04550 Signaling pathways regulating pluripotency of stem cells ESRRG 65.92788737 78.0310412 53.82473354 0.689786176 -0.535778878 0.327186525 1 0.366743571 0.248741458 2104 estrogen related receptor gamma "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003707,GO:0004879,GO:0005496,GO:0005515,GO:0005654,GO:0006355,GO:0006357,GO:0006367,GO:0008270,GO:0043401,GO:0045893,GO:0045944,GO:0048384,GO:0050682,GO:0120162,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|steroid hormone receptor activity|nuclear receptor activity|steroid binding|protein binding|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|zinc ion binding|steroid hormone mediated signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|retinoic acid receptor signaling pathway|AF-2 domain binding|positive regulation of cold-induced thermogenesis|sequence-specific double-stranded DNA binding" ESS2 434.4299737 428.6505196 440.2094278 1.026965809 0.038388151 0.900362459 1 3.536294699 3.57088294 8220 ess-2 splicing factor homolog "GO:0000398,GO:0003674,GO:0005515,GO:0005634,GO:0007399,GO:0071013" "mRNA splicing, via spliceosome|molecular_function|protein binding|nucleus|nervous system development|catalytic step 2 spliceosome" ESYT1 3711.27966 3438.567882 3983.991438 1.158619395 0.21240672 0.371605456 1 43.58908505 49.65805735 23344 extended synaptotagmin 1 "GO:0005509,GO:0005515,GO:0005544,GO:0005783,GO:0005789,GO:0006687,GO:0006869,GO:0008429,GO:0016020,GO:0030176,GO:0031210,GO:0031227,GO:0031234,GO:0035091,GO:0042802,GO:0061817" calcium ion binding|protein binding|calcium-dependent phospholipid binding|endoplasmic reticulum|endoplasmic reticulum membrane|glycosphingolipid metabolic process|lipid transport|phosphatidylethanolamine binding|membrane|integral component of endoplasmic reticulum membrane|phosphatidylcholine binding|intrinsic component of endoplasmic reticulum membrane|extrinsic component of cytoplasmic side of plasma membrane|phosphatidylinositol binding|identical protein binding|endoplasmic reticulum-plasma membrane tethering ESYT2 3202.215446 3170.1411 3234.289792 1.02023528 0.028901895 0.904216197 1 24.57292724 24.650652 57488 extended synaptotagmin 2 "GO:0005509,GO:0005515,GO:0005544,GO:0005789,GO:0005887,GO:0006687,GO:0006869,GO:0006897,GO:0008429,GO:0016020,GO:0031210,GO:0031227,GO:0031234,GO:0035091,GO:0042802,GO:0044232,GO:0045296,GO:0061817,GO:0140268" calcium ion binding|protein binding|calcium-dependent phospholipid binding|endoplasmic reticulum membrane|integral component of plasma membrane|glycosphingolipid metabolic process|lipid transport|endocytosis|phosphatidylethanolamine binding|membrane|phosphatidylcholine binding|intrinsic component of endoplasmic reticulum membrane|extrinsic component of cytoplasmic side of plasma membrane|phosphatidylinositol binding|identical protein binding|organelle membrane contact site|cadherin binding|endoplasmic reticulum-plasma membrane tethering|endoplasmic reticulum-plasma membrane contact site ETAA1 736.5135339 726.2088901 746.8181778 1.028379283 0.040372452 0.879129938 1 7.807500755 7.894716383 54465 ETAA1 activator of ATR kinase "GO:0005515,GO:0005654,GO:0005829,GO:0006281,GO:0006974,GO:0031297,GO:0043539,GO:0043596,GO:0071902,GO:2000001" protein binding|nucleoplasm|cytosol|DNA repair|cellular response to DNA damage stimulus|replication fork processing|protein serine/threonine kinase activator activity|nuclear replication fork|positive regulation of protein serine/threonine kinase activity|regulation of DNA damage checkpoint ETF1 3949.921282 3849.531366 4050.311199 1.052156955 0.073349934 0.758719245 1 49.19598033 50.89572767 2107 eukaryotic translation termination factor 1 "GO:0000184,GO:0002184,GO:0003723,GO:0003747,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006415,GO:0006449,GO:0006479,GO:0008079,GO:0016149,GO:0018444,GO:0043022,GO:1990825" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translational termination|RNA binding|translation release factor activity|protein binding|nucleus|cytoplasm|cytosol|translational termination|regulation of translational termination|protein methylation|translation termination factor activity|translation release factor activity, codon specific|translation release factor complex|ribosome binding|sequence-specific mRNA binding" hsa03015 mRNA surveillance pathway ETFA 1486.473805 1376.467567 1596.480043 1.159838475 0.213923902 0.37072399 1 32.09241774 36.59916072 2108 electron transfer flavoprotein subunit alpha "GO:0005515,GO:0005739,GO:0005759,GO:0009055,GO:0016491,GO:0022904,GO:0033539,GO:0050660" protein binding|mitochondrion|mitochondrial matrix|electron transfer activity|oxidoreductase activity|respiratory electron transport chain|fatty acid beta-oxidation using acyl-CoA dehydrogenase|flavin adenine dinucleotide binding ETFB 704.4984774 667.9457127 741.0512421 1.10944831 0.149842453 0.560962875 1 35.12023158 38.31207043 2109 electron transfer flavoprotein subunit beta "GO:0005515,GO:0005739,GO:0005759,GO:0009055,GO:0022904,GO:0033539" protein binding|mitochondrion|mitochondrial matrix|electron transfer activity|respiratory electron transport chain|fatty acid beta-oxidation using acyl-CoA dehydrogenase ETFBKMT 23.45900216 22.88910542 24.0288989 1.049796332 0.070109461 0.99116579 1 0.166355643 0.171717188 254013 electron transfer flavoprotein subunit beta lysine methyltransferase "GO:0005737,GO:0005759,GO:0006479,GO:0016279,GO:0018022,GO:0018023,GO:0031072,GO:0032991,GO:1904733,GO:1904736" cytoplasm|mitochondrial matrix|protein methylation|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation|peptidyl-lysine trimethylation|heat shock protein binding|protein-containing complex|negative regulation of electron transfer activity|negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase ETFDH 306.2848447 306.9220954 305.647594 0.995847476 -0.006003299 0.996652404 1 6.958312715 6.813463726 2110 electron transfer flavoprotein dehydrogenase "GO:0004174,GO:0005515,GO:0005759,GO:0006979,GO:0009055,GO:0016491,GO:0022900,GO:0022904,GO:0031305,GO:0031966,GO:0033539,GO:0043783,GO:0046872,GO:0048038,GO:0048039,GO:0050660,GO:0051539" "electron-transferring-flavoprotein dehydrogenase activity|protein binding|mitochondrial matrix|response to oxidative stress|electron transfer activity|oxidoreductase activity|electron transport chain|respiratory electron transport chain|integral component of mitochondrial inner membrane|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|oxidoreductase activity, oxidizing metal ions with flavin as acceptor|metal ion binding|quinone binding|ubiquinone binding|flavin adenine dinucleotide binding|4 iron, 4 sulfur cluster binding" ETFRF1 154.3586514 166.4662212 142.2510815 0.854534214 -0.226789839 0.580164185 1 3.318638877 2.788435678 144363 electron transfer flavoprotein regulatory factor 1 "GO:0005515,GO:0005739,GO:0022904" protein binding|mitochondrion|respiratory electron transport chain ETHE1 926.6431613 872.9072475 980.3790751 1.123119413 0.167511327 0.500341939 1 43.13468099 47.63472945 23474 ETHE1 persulfide dioxygenase "GO:0005506,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006749,GO:0016788,GO:0042802,GO:0050313,GO:0070221,GO:0070813" "iron ion binding|protein binding|nucleoplasm|cytoplasm|mitochondrion|mitochondrial matrix|glutathione metabolic process|hydrolase activity, acting on ester bonds|identical protein binding|sulfur dioxygenase activity|sulfide oxidation, using sulfide:quinone oxidoreductase|hydrogen sulfide metabolic process" hsa00920 Sulfur metabolism ETNK1 1310.240695 1329.648942 1290.832449 0.970806961 -0.042743641 0.86192223 1 6.149126538 5.869721428 55500 ethanolamine kinase 1 "GO:0004305,GO:0005515,GO:0005524,GO:0005829,GO:0006646,GO:0016020,GO:0016310" ethanolamine kinase activity|protein binding|ATP binding|cytosol|phosphatidylethanolamine biosynthetic process|membrane|phosphorylation hsa00564 Glycerophospholipid metabolism ETNK2 1104.6143 1078.909196 1130.319404 1.047650171 0.067157056 0.785967628 1 17.71673872 18.25035209 55224 ethanolamine kinase 2 "GO:0001701,GO:0001890,GO:0004305,GO:0005515,GO:0005524,GO:0005575,GO:0005829,GO:0006646,GO:0008150,GO:0009791,GO:0016310,GO:0035264" in utero embryonic development|placenta development|ethanolamine kinase activity|protein binding|ATP binding|cellular_component|cytosol|phosphatidylethanolamine biosynthetic process|biological_process|post-embryonic development|phosphorylation|multicellular organism growth hsa00564 Glycerophospholipid metabolism ETS1 5729.437714 6194.624257 5264.251171 0.849809601 -0.234788451 0.331157359 1 58.64745634 49.00518045 2113 "ETS proto-oncogene 1, transcription factor" "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001666,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006955,GO:0007565,GO:0008134,GO:0008284,GO:0008285,GO:0009612,GO:0010595,GO:0010628,GO:0010715,GO:0021854,GO:0021983,GO:0030154,GO:0030578,GO:0032355,GO:0034616,GO:0035035,GO:0042802,GO:0043536,GO:0044849,GO:0045648,GO:0045765,GO:0045766,GO:0045893,GO:0045944,GO:0048870,GO:0050729,GO:0051272,GO:0060055,GO:0070301,GO:0070555,GO:1902895,GO:1904996" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|response to hypoxia|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|immune response|female pregnancy|transcription factor binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|response to mechanical stimulus|positive regulation of endothelial cell migration|positive regulation of gene expression|regulation of extracellular matrix disassembly|hypothalamus development|pituitary gland development|cell differentiation|PML body organization|response to estradiol|response to laminar fluid shear stress|histone acetyltransferase binding|identical protein binding|positive regulation of blood vessel endothelial cell migration|estrous cycle|positive regulation of erythrocyte differentiation|regulation of angiogenesis|positive regulation of angiogenesis|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cell motility|positive regulation of inflammatory response|positive regulation of cellular component movement|angiogenesis involved in wound healing|cellular response to hydrogen peroxide|response to interleukin-1|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of leukocyte adhesion to vascular endothelial cell" "hsa04014,hsa04218,hsa05166,hsa05200,hsa05211" Ras signaling pathway|Cellular senescence|Human T-cell leukemia virus 1 infection|Pathways in cancer|Renal cell carcinoma ETS ETS2 2101.971621 1978.867205 2225.076038 1.124419078 0.169179837 0.474922937 1 14.22336777 15.72540445 2114 "ETS proto-oncogene 2, transcription factor" "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001501,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006357,GO:0019904,GO:0030154,GO:0045893,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|skeletal system development|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|protein domain specific binding|cell differentiation|positive regulation of transcription, DNA-templated|sequence-specific double-stranded DNA binding" "hsa04014,hsa05166" Ras signaling pathway|Human T-cell leukemia virus 1 infection ETS ETV1 1376.515183 1442.013641 1311.016724 0.90915695 -0.137398723 0.567913875 1 10.19171206 9.110814131 2115 ETS variant transcription factor 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0006366,GO:0030154,GO:0045944,GO:0048935,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|cell differentiation|positive regulation of transcription by RNA polymerase II|peripheral nervous system neuron development|sequence-specific double-stranded DNA binding" hsa05202 Transcriptional misregulation in cancer ETS ETV2 4.042768641 5.202069413 2.883467868 0.554292463 -0.851280704 0.745112452 1 0.128708801 0.070148501 2116 ETS variant transcription factor 2 "GO:0000978,GO:0000981,GO:0001228,GO:0001824,GO:0001890,GO:0005634,GO:0006357,GO:0007219,GO:0016055,GO:0030154,GO:0030218,GO:0045603,GO:0045944,GO:0048514,GO:0060803,GO:1990837,GO:2000382" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|blastocyst development|placenta development|nucleus|regulation of transcription by RNA polymerase II|Notch signaling pathway|Wnt signaling pathway|cell differentiation|erythrocyte differentiation|positive regulation of endothelial cell differentiation|positive regulation of transcription by RNA polymerase II|blood vessel morphogenesis|BMP signaling pathway involved in mesodermal cell fate specification|sequence-specific double-stranded DNA binding|positive regulation of mesoderm development" ETV3 731.9549744 808.4015868 655.508362 0.810869712 -0.302457969 0.234939741 1 6.903969741 5.504541327 2117 ETS variant transcription factor 3 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0005654,GO:0006357,GO:0008150,GO:0008285,GO:0017151,GO:0030154,GO:0043231,GO:0090571,GO:0097011,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|biological_process|negative regulation of cell population proliferation|DEAD/H-box RNA helicase binding|cell differentiation|intracellular membrane-bounded organelle|RNA polymerase II transcription repressor complex|cellular response to granulocyte macrophage colony-stimulating factor stimulus|sequence-specific double-stranded DNA binding" ETV4 1287.578689 1416.003294 1159.154083 0.818609736 -0.28875227 0.230569292 1 27.86485742 22.42874169 2118 ETS variant transcription factor 4 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0006357,GO:0030154,GO:0045618,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|regulation of transcription by RNA polymerase II|cell differentiation|positive regulation of keratinocyte differentiation|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" hsa05202 Transcriptional misregulation in cancer ETS ETV5 2295.780483 2436.649313 2154.911653 0.884374966 -0.177269908 0.453665447 1 31.85680928 27.70192152 2119 ETS variant transcription factor 5 "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0030154,GO:0034599,GO:0045666,GO:0045944,GO:0048133,GO:0060252,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cell differentiation|cellular response to oxidative stress|positive regulation of neuron differentiation|positive regulation of transcription by RNA polymerase II|male germ-line stem cell asymmetric division|positive regulation of glial cell proliferation|sequence-specific double-stranded DNA binding" "hsa05202,hsa05215" Transcriptional misregulation in cancer|Prostate cancer ETS ETV6 1073.450345 1194.395137 952.5055524 0.797479429 -0.326480789 0.181400365 1 6.589752225 5.167253325 2120 ETS variant transcription factor 6 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005730,GO:0005829,GO:0006357,GO:0007296,GO:0019904,GO:0022008,GO:0030154,GO:0045944,GO:0071425,GO:0097152" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleolus|cytosol|regulation of transcription by RNA polymerase II|vitellogenesis|protein domain specific binding|neurogenesis|cell differentiation|positive regulation of transcription by RNA polymerase II|hematopoietic stem cell proliferation|mesenchymal cell apoptotic process" hsa05202 Transcriptional misregulation in cancer ETS ETV7 5.965080553 5.202069413 6.728091692 1.29334908 0.371111717 0.919461532 1 0.116063915 0.14759925 51513 ETS variant transcription factor 7 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006366,GO:0009887,GO:0030154,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|animal organ morphogenesis|cell differentiation|sequence-specific double-stranded DNA binding" hsa05202 Transcriptional misregulation in cancer ETS EVA1A 800.2913965 773.0275148 827.5552781 1.070537933 0.098335917 0.699402021 1 18.47517138 19.44740752 84141 "eva-1 homolog A, regulator of programmed cell death" "GO:0005515,GO:0005765,GO:0005788,GO:0005789,GO:0005886,GO:0006914,GO:0006915,GO:0016021,GO:0043231,GO:0043687,GO:0044267" protein binding|lysosomal membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|plasma membrane|autophagy|apoptotic process|integral component of membrane|intracellular membrane-bounded organelle|post-translational protein modification|cellular protein metabolic process EVA1B 325.5180246 281.9521622 369.0838871 1.309030171 0.388498349 0.206077122 1 12.11535321 15.59397793 55194 eva-1 homolog B "GO:0005515,GO:0016021" protein binding|integral component of membrane EVA1C 99.04813889 76.99062732 121.1056505 1.572992125 0.653511448 0.164893023 1 1.136296537 1.757476028 59271 eva-1 homolog C "GO:0005576,GO:0008150,GO:0008201,GO:0016021,GO:0030246" extracellular region|biological_process|heparin binding|integral component of membrane|carbohydrate binding EVC 3576.56507 4115.87732 3037.252821 0.737935702 -0.438432978 0.065045129 1 24.13811076 17.51430777 2121 EvC ciliary complex subunit 1 "GO:0001501,GO:0003416,GO:0005737,GO:0005929,GO:0007224,GO:0007517,GO:0016021,GO:0036064,GO:0045880,GO:0051216,GO:0060170,GO:0098797" skeletal system development|endochondral bone growth|cytoplasm|cilium|smoothened signaling pathway|muscle organ development|integral component of membrane|ciliary basal body|positive regulation of smoothened signaling pathway|cartilage development|ciliary membrane|plasma membrane protein complex hsa04340 Hedgehog signaling pathway EVC2 119.4500661 133.172977 105.7271552 0.793908476 -0.332955396 0.454932029 1 1.091400034 0.851972506 132884 EvC ciliary complex subunit 2 "GO:0005634,GO:0005737,GO:0005856,GO:0005929,GO:0007224,GO:0016021,GO:0060170,GO:0098797" nucleus|cytoplasm|cytoskeleton|cilium|smoothened signaling pathway|integral component of membrane|ciliary membrane|plasma membrane protein complex hsa04340 Hedgehog signaling pathway EVI2A 190.862456 216.4060876 165.3188244 0.763928715 -0.388490073 0.295272266 1 4.005964328 3.009061688 2123 ecotropic viral integration site 2A "GO:0004888,GO:0005515,GO:0016021" transmembrane signaling receptor activity|protein binding|integral component of membrane EVI2B 97.39316888 109.2434577 85.54288008 0.783048083 -0.352827197 0.461971225 1 2.900558485 2.23327002 2124 ecotropic viral integration site 2B "GO:0005887,GO:0030854,GO:0043066,GO:0045660,GO:0061515,GO:0071157,GO:2000035" integral component of plasma membrane|positive regulation of granulocyte differentiation|negative regulation of apoptotic process|positive regulation of neutrophil differentiation|myeloid cell development|negative regulation of cell cycle arrest|regulation of stem cell division EVI5 1039.092763 986.3123607 1091.873166 1.107025735 0.146688761 0.551094428 1 5.995862618 6.526503406 7813 ecotropic viral integration site 5 "GO:0005096,GO:0005515,GO:0005634,GO:0005815,GO:0005819,GO:0005829,GO:0006886,GO:0007049,GO:0031267,GO:0042147,GO:0043547,GO:0051301,GO:0090630,GO:1902017" "GTPase activator activity|protein binding|nucleus|microtubule organizing center|spindle|cytosol|intracellular protein transport|cell cycle|small GTPase binding|retrograde transport, endosome to Golgi|positive regulation of GTPase activity|cell division|activation of GTPase activity|regulation of cilium assembly" EVI5L 507.9829421 467.1458333 548.8200509 1.174836661 0.232460191 0.395126564 1 6.387577388 7.378784786 115704 ecotropic viral integration site 5 like "GO:0005096,GO:0005515,GO:0006886,GO:0031267,GO:0043547,GO:0090630,GO:1902018" GTPase activator activity|protein binding|intracellular protein transport|small GTPase binding|positive regulation of GTPase activity|activation of GTPase activity|negative regulation of cilium assembly EVL 554.563793 554.5405994 554.5869866 1.00008365 0.000120676 1 1 7.790158618 7.660441604 51466 Enah/Vasp-like "GO:0003779,GO:0005515,GO:0005522,GO:0005737,GO:0005829,GO:0005856,GO:0005925,GO:0007015,GO:0007166,GO:0007399,GO:0007411,GO:0008154,GO:0009887,GO:0010633,GO:0016020,GO:0017124,GO:0030027,GO:0030838,GO:0045010,GO:0051289,GO:0051496,GO:1900028" actin binding|protein binding|profilin binding|cytoplasm|cytosol|cytoskeleton|focal adhesion|actin filament organization|cell surface receptor signaling pathway|nervous system development|axon guidance|actin polymerization or depolymerization|animal organ morphogenesis|negative regulation of epithelial cell migration|membrane|SH3 domain binding|lamellipodium|positive regulation of actin filament polymerization|actin nucleation|protein homotetramerization|positive regulation of stress fiber assembly|negative regulation of ruffle assembly hsa04015 Rap1 signaling pathway EVPL 476.2352274 441.1354862 511.3349686 1.15913361 0.213046871 0.443394973 1 3.60309001 4.106575283 2125 envoplakin "GO:0001533,GO:0005198,GO:0005737,GO:0005829,GO:0005882,GO:0008544,GO:0016020,GO:0018149,GO:0019215,GO:0030057,GO:0030216,GO:0042060,GO:0045104,GO:0045111,GO:0045296,GO:0070062,GO:0070268" cornified envelope|structural molecule activity|cytoplasm|cytosol|intermediate filament|epidermis development|membrane|peptide cross-linking|intermediate filament binding|desmosome|keratinocyte differentiation|wound healing|intermediate filament cytoskeleton organization|intermediate filament cytoskeleton|cadherin binding|extracellular exosome|cornification EWSR1 4481.630568 4371.819135 4591.442002 1.050236037 0.070713605 0.767986598 1 35.97778754 37.15288536 2130 EWS RNA binding protein 1 "GO:0003712,GO:0003723,GO:0005515,GO:0005516,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005886,GO:0006355,GO:0042802,GO:0046872" "transcription coregulator activity|RNA binding|protein binding|calmodulin binding|nucleus|nucleoplasm|nucleolus|cytoplasm|plasma membrane|regulation of transcription, DNA-templated|identical protein binding|metal ion binding" hsa05202 Transcriptional misregulation in cancer other EXD2 664.80865 673.1477821 656.4695179 0.975223473 -0.036195244 0.894378954 1 7.28399431 6.984654404 55218 exonuclease 3'-5' domain containing 2 "GO:0000175,GO:0000287,GO:0000724,GO:0000729,GO:0003676,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005741,GO:0005759,GO:0006302,GO:0008296,GO:0008310,GO:0008408,GO:0008852,GO:0016021,GO:0030145,GO:0031297,GO:0042803,GO:0045111,GO:0090305,GO:0090503,GO:0090734" "3'-5'-exoribonuclease activity|magnesium ion binding|double-strand break repair via homologous recombination|DNA double-strand break processing|nucleic acid binding|protein binding|nucleus|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial matrix|double-strand break repair|3'-5'-exodeoxyribonuclease activity|single-stranded DNA 3'-5' exodeoxyribonuclease activity|3'-5' exonuclease activity|exodeoxyribonuclease I activity|integral component of membrane|manganese ion binding|replication fork processing|protein homodimerization activity|intermediate filament cytoskeleton|nucleic acid phosphodiester bond hydrolysis|RNA phosphodiester bond hydrolysis, exonucleolytic|site of DNA damage" EXD3 133.4264564 134.2133909 132.6395219 0.988273384 -0.017017909 0.988007775 1 1.333095477 1.295416822 54932 exonuclease 3'-5' domain containing 3 "GO:0003676,GO:0005515,GO:0008408,GO:0046872,GO:0090305" nucleic acid binding|protein binding|3'-5' exonuclease activity|metal ion binding|nucleic acid phosphodiester bond hydrolysis EXO1 1015.45954 1097.636646 933.2824333 0.850265374 -0.234014908 0.340960993 1 15.27081607 12.76697236 9156 exonuclease 1 "GO:0002455,GO:0003677,GO:0003682,GO:0004523,GO:0004527,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0008409,GO:0016446,GO:0016604,GO:0017108,GO:0035312,GO:0045145,GO:0045190,GO:0046872,GO:0048256,GO:0051321,GO:0051908,GO:0090502,GO:0090656,GO:1901796" "humoral immune response mediated by circulating immunoglobulin|DNA binding|chromatin binding|RNA-DNA hybrid ribonuclease activity|exonuclease activity|protein binding|nucleus|nucleoplasm|plasma membrane|DNA replication|DNA repair|mismatch repair|DNA recombination|5'-3' exonuclease activity|somatic hypermutation of immunoglobulin genes|nuclear body|5'-flap endonuclease activity|5'-3' exodeoxyribonuclease activity|single-stranded DNA 5'-3' exodeoxyribonuclease activity|isotype switching|metal ion binding|flap endonuclease activity|meiotic cell cycle|double-stranded DNA 5'-3' exodeoxyribonuclease activity|RNA phosphodiester bond hydrolysis, endonucleolytic|t-circle formation|regulation of signal transduction by p53 class mediator" hsa03430 Mismatch repair EXO5 177.2477568 212.2444321 142.2510815 0.670222913 -0.577287086 0.129197562 1 4.558187223 3.003880205 64789 exonuclease 5 "GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0008310,GO:0036297,GO:0045145,GO:0046872,GO:0051539,GO:0090305" "DNA binding|nucleus|nucleoplasm|cytosol|single-stranded DNA 3'-5' exodeoxyribonuclease activity|interstrand cross-link repair|single-stranded DNA 5'-3' exodeoxyribonuclease activity|metal ion binding|4 iron, 4 sulfur cluster binding|nucleic acid phosphodiester bond hydrolysis" EXOC1 1412.806366 1423.286191 1402.32654 0.985273762 -0.021403457 0.931853496 1 12.82860465 12.42817951 55763 exocyst complex component 1 "GO:0000145,GO:0005515,GO:0005546,GO:0005737,GO:0005829,GO:0005886,GO:0006887,GO:0006893,GO:0015031,GO:0016020,GO:0016032,GO:0016241,GO:0048015,GO:0048471,GO:0050714,GO:0051601,GO:0051607,GO:0090543,GO:0098592" "exocyst|protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|cytosol|plasma membrane|exocytosis|Golgi to plasma membrane transport|protein transport|membrane|viral process|regulation of macroautophagy|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|positive regulation of protein secretion|exocyst localization|defense response to virus|Flemming body|cytoplasmic side of apical plasma membrane" EXOC2 1569.355285 1521.085096 1617.625474 1.063468098 0.088776755 0.711148382 1 7.022883983 7.343635945 55770 exocyst complex component 2 "GO:0000145,GO:0005515,GO:0005829,GO:0005886,GO:0006887,GO:0006893,GO:0015031,GO:0016020,GO:0019901,GO:0031267,GO:0047485,GO:0090543,GO:2000535" exocyst|protein binding|cytosol|plasma membrane|exocytosis|Golgi to plasma membrane transport|protein transport|membrane|protein kinase binding|small GTPase binding|protein N-terminus binding|Flemming body|regulation of entry of bacterium into host cell "hsa04014,hsa05132" Ras signaling pathway|Salmonella infection EXOC3 921.7279411 945.7362193 897.7196629 0.949228384 -0.075172854 0.765003615 1 18.0193516 16.81825969 11336 exocyst complex component 3 "GO:0000145,GO:0000149,GO:0005515,GO:0005794,GO:0005829,GO:0006887,GO:0015031,GO:0030426,GO:0030496,GO:0030667,GO:0042734,GO:0045296,GO:0048471,GO:0051601" exocyst|SNARE binding|protein binding|Golgi apparatus|cytosol|exocytosis|protein transport|growth cone|midbody|secretory granule membrane|presynaptic membrane|cadherin binding|perinuclear region of cytoplasm|exocyst localization EXOC3L4 4.964295633 4.161655531 5.766935736 1.385731158 0.470647391 0.897151737 1 0.037352827 0.050894826 91828 exocyst complex component 3 like 4 "GO:0000145,GO:0000149,GO:0006887,GO:0051601" exocyst|SNARE binding|exocytosis|exocyst localization EXOC4 2364.321309 2192.152051 2536.490568 1.157077844 0.210485927 0.373443495 1 13.96242105 15.88526581 60412 exocyst complex component 4 "GO:0000145,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005902,GO:0006612,GO:0006887,GO:0006893,GO:0006904,GO:0007268,GO:0016020,GO:0016241,GO:0030165,GO:0031267,GO:0032584,GO:0035748,GO:0045202,GO:0047485,GO:0048341,GO:0090522,GO:0090543" exocyst|protein binding|cytoplasm|cytosol|plasma membrane|microvillus|protein targeting to membrane|exocytosis|Golgi to plasma membrane transport|vesicle docking involved in exocytosis|chemical synaptic transmission|membrane|regulation of macroautophagy|PDZ domain binding|small GTPase binding|growth cone membrane|myelin sheath abaxonal region|synapse|protein N-terminus binding|paraxial mesoderm formation|vesicle tethering involved in exocytosis|Flemming body hsa05132 Salmonella infection EXOC5 2031.658782 1949.735616 2113.581947 1.084035153 0.116411541 0.623725854 1 9.816396827 10.46325117 10640 exocyst complex component 5 "GO:0000145,GO:0005515,GO:0005737,GO:0005829,GO:0006887,GO:0006892,GO:0006893,GO:0015031,GO:0030496,GO:0031267" exocyst|protein binding|cytoplasm|cytosol|exocytosis|post-Golgi vesicle-mediated transport|Golgi to plasma membrane transport|protein transport|midbody|small GTPase binding hsa05132 Salmonella infection EXOC6 734.7094945 830.2502783 639.1687107 0.769850643 -0.377349516 0.137908232 1 7.596250886 5.750120628 54536 exocyst complex component 6 "GO:0000145,GO:0005515,GO:0005829,GO:0005886,GO:0006887,GO:0006893,GO:0006904,GO:0015031,GO:0016020,GO:0030426,GO:0048471,GO:0090543" exocyst|protein binding|cytosol|plasma membrane|exocytosis|Golgi to plasma membrane transport|vesicle docking involved in exocytosis|protein transport|membrane|growth cone|perinuclear region of cytoplasm|Flemming body EXOC6B 1682.861007 1498.195991 1867.526022 1.2465165 0.317901979 0.180884682 1 8.641085753 10.59101358 23233 exocyst complex component 6B "GO:0000145,GO:0005515,GO:0006887,GO:0006893,GO:0006904,GO:0015031,GO:0016020" exocyst|protein binding|exocytosis|Golgi to plasma membrane transport|vesicle docking involved in exocytosis|protein transport|membrane EXOC7 2466.178074 2355.49703 2576.859118 1.093976806 0.129582151 0.584279057 1 21.15593189 22.75681365 23265 exocyst complex component 7 "GO:0000145,GO:0005515,GO:0005815,GO:0005829,GO:0005886,GO:0006887,GO:0015031,GO:0016020,GO:0016241,GO:0032584,GO:0034451,GO:0090543,GO:2000535" exocyst|protein binding|microtubule organizing center|cytosol|plasma membrane|exocytosis|protein transport|membrane|regulation of macroautophagy|growth cone membrane|centriolar satellite|Flemming body|regulation of entry of bacterium into host cell "hsa04910,hsa05132" Insulin signaling pathway|Salmonella infection EXOC8 496.1068868 521.2473552 470.9664184 0.903537282 -0.146343964 0.596925403 1 5.454512419 4.845885972 149371 exocyst complex component 8 "GO:0000145,GO:0005515,GO:0005770,GO:0005829,GO:0005886,GO:0006887,GO:0006893,GO:0007032,GO:0008104,GO:0015031,GO:0016020,GO:0016241,GO:0022617,GO:0030426,GO:0031252,GO:0031267,GO:0034613,GO:0035091,GO:0048471" exocyst|protein binding|late endosome|cytosol|plasma membrane|exocytosis|Golgi to plasma membrane transport|endosome organization|protein localization|protein transport|membrane|regulation of macroautophagy|extracellular matrix disassembly|growth cone|cell leading edge|small GTPase binding|cellular protein localization|phosphatidylinositol binding|perinuclear region of cytoplasm EXOG 301.5683837 284.03299 319.1037774 1.123474345 0.167967181 0.598747175 1 2.402649967 2.654146208 9941 exo/endonuclease G "GO:0000014,GO:0003676,GO:0004519,GO:0004521,GO:0005634,GO:0005739,GO:0005743,GO:0006309,GO:0008150,GO:0008409,GO:0032991,GO:0046872,GO:0090502" "single-stranded DNA endodeoxyribonuclease activity|nucleic acid binding|endonuclease activity|endoribonuclease activity|nucleus|mitochondrion|mitochondrial inner membrane|apoptotic DNA fragmentation|biological_process|5'-3' exonuclease activity|protein-containing complex|metal ion binding|RNA phosphodiester bond hydrolysis, endonucleolytic" EXOSC1 1093.605666 1067.464644 1119.746689 1.048977777 0.068984114 0.780390147 1 44.05926227 45.44380495 51013 exosome component 1 "GO:0000176,GO:0000178,GO:0003723,GO:0004532,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0043488,GO:0043928,GO:0090503" "nuclear exosome (RNase complex)|exosome (RNase complex)|RNA binding|exoribonuclease activity|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation EXOSC10 2139.683802 2110.999768 2168.367837 1.027175782 0.038683093 0.871907501 1 38.12527166 38.50604347 5394 exosome component 10 "GO:0000166,GO:0000175,GO:0000176,GO:0000178,GO:0000184,GO:0000460,GO:0000467,GO:0000956,GO:0003723,GO:0003727,GO:0004532,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0009048,GO:0016020,GO:0032211,GO:0035327,GO:0070034,GO:0071028,GO:0071034,GO:0071035,GO:0071036,GO:0071037,GO:0071038,GO:0071039,GO:0071040,GO:0071044,GO:0071048,GO:0071051,GO:1904872" "nucleotide binding|3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|exosome (RNase complex)|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of 5.8S rRNA|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process|RNA binding|single-stranded RNA binding|exoribonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|dosage compensation by inactivation of X chromosome|membrane|negative regulation of telomere maintenance via telomerase|transcriptionally active chromatin|telomerase RNA binding|nuclear mRNA surveillance|CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|histone mRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|polyadenylation-dependent snoRNA 3'-end processing|regulation of telomerase RNA localization to Cajal body" hsa03018 RNA degradation EXOSC2 1030.105206 1027.928916 1032.281497 1.004234321 0.006095936 0.984655198 1 26.99738041 26.65801846 23404 exosome component 2 "GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0000467,GO:0003723,GO:0004532,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0008312,GO:0030307,GO:0034427,GO:0034475,GO:0043488,GO:0043928,GO:0071034,GO:0071035,GO:0071038,GO:0071049,GO:0071051" "3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|exoribonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|7S RNA binding|positive regulation of cell growth|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U4 snRNA 3'-end processing|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription|polyadenylation-dependent snoRNA 3'-end processing" hsa03018 RNA degradation EXOSC3 643.807258 613.8441908 673.7703252 1.097624341 0.13438438 0.608128743 1 18.0693526 19.50147679 51010 exosome component 3 "GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0000467,GO:0003723,GO:0004532,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0034427,GO:0034475,GO:0035327,GO:0043488,GO:0043928,GO:0045006,GO:0045190,GO:0045830,GO:0071034,GO:0071035,GO:0071038,GO:0071049,GO:0071051" "3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|exoribonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U4 snRNA 3'-end processing|transcriptionally active chromatin|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|DNA deamination|isotype switching|positive regulation of isotype switching|CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription|polyadenylation-dependent snoRNA 3'-end processing" hsa03018 RNA degradation EXOSC4 365.9954009 310.043337 421.9474647 1.3609306 0.444593499 0.133843811 1 16.35024018 21.87919275 54512 exosome component 4 "GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0000460,GO:0000956,GO:0004532,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0016075,GO:0030307,GO:0034427,GO:0034475,GO:0035327,GO:0035925,GO:0043231,GO:0043488,GO:0043928,GO:0045006,GO:0051607,GO:0071028,GO:0071044,GO:0071051,GO:0090503" "3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|maturation of 5.8S rRNA|nuclear-transcribed mRNA catabolic process|exoribonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|rRNA catabolic process|positive regulation of cell growth|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U4 snRNA 3'-end processing|transcriptionally active chromatin|mRNA 3'-UTR AU-rich region binding|intracellular membrane-bounded organelle|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|DNA deamination|defense response to virus|nuclear mRNA surveillance|histone mRNA catabolic process|polyadenylation-dependent snoRNA 3'-end processing|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation EXOSC5 178.9027268 179.9916017 177.8138519 0.987900825 -0.017561877 0.97962517 1 9.625071114 9.349501891 56915 exosome component 5 "GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0003723,GO:0004532,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0016075,GO:0034427,GO:0034475,GO:0035327,GO:0043488,GO:0043928,GO:0045006,GO:0051607,GO:0071028,GO:0071051,GO:0090503" "3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|RNA binding|exoribonuclease activity|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|rRNA catabolic process|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U4 snRNA 3'-end processing|transcriptionally active chromatin|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|DNA deamination|defense response to virus|nuclear mRNA surveillance|polyadenylation-dependent snoRNA 3'-end processing|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation EXOSC6 553.7611529 558.702255 548.8200509 0.982312217 -0.025746453 0.930372555 1 5.77511379 5.578035448 118460 exosome component 6 "GO:0000176,GO:0000177,GO:0000178,GO:0003723,GO:0004532,GO:0005654,GO:0005730,GO:0005829,GO:0006364,GO:0016075,GO:0034427,GO:0034475,GO:0043488,GO:0043928,GO:0045006,GO:0045190,GO:0045830,GO:0071028,GO:0071051,GO:0090503" "nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|RNA binding|exoribonuclease activity|nucleoplasm|nucleolus|cytosol|rRNA processing|rRNA catabolic process|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U4 snRNA 3'-end processing|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|DNA deamination|isotype switching|positive regulation of isotype switching|nuclear mRNA surveillance|polyadenylation-dependent snoRNA 3'-end processing|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation EXOSC7 530.9217373 488.9945248 572.8489498 1.171483362 0.228336464 0.398880045 1 24.78322797 28.54730895 23016 exosome component 7 "GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0000467,GO:0003723,GO:0004532,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006364,GO:0006401,GO:0016075,GO:0034427,GO:0034473,GO:0034475,GO:0034476,GO:0035925,GO:0043488,GO:0043928,GO:0071028,GO:0071035,GO:0071038,GO:0071042" "3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|exoribonuclease activity|protein binding|nucleoplasm|nucleolus|cytosol|rRNA processing|RNA catabolic process|rRNA catabolic process|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U1 snRNA 3'-end processing|U4 snRNA 3'-end processing|U5 snRNA 3'-end processing|mRNA 3'-UTR AU-rich region binding|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process" hsa03018 RNA degradation EXOSC8 1242.182905 1170.465618 1313.900192 1.122544884 0.166773132 0.490933454 1 39.56022724 43.66502078 11340 exosome component 8 "GO:0000176,GO:0000177,GO:0000178,GO:0000467,GO:0001650,GO:0004532,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0006364,GO:0008150,GO:0016075,GO:0034427,GO:0034473,GO:0034475,GO:0034476,GO:0035925,GO:0042802,GO:0043231,GO:0043488,GO:0043928,GO:0071028,GO:0071035,GO:0071038,GO:0071042" "nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|fibrillar center|exoribonuclease activity|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|cytosol|rRNA processing|biological_process|rRNA catabolic process|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U1 snRNA 3'-end processing|U4 snRNA 3'-end processing|U5 snRNA 3'-end processing|mRNA 3'-UTR AU-rich region binding|identical protein binding|intracellular membrane-bounded organelle|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process" hsa03018 RNA degradation EXOSC9 866.4627024 743.8959261 989.0294787 1.329526677 0.410912725 0.099374549 1 20.87295392 27.28677117 5393 exosome component 9 "GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0000228,GO:0000467,GO:0000956,GO:0001102,GO:0003723,GO:0004532,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0006955,GO:0016075,GO:0030307,GO:0034427,GO:0034473,GO:0034475,GO:0034476,GO:0035925,GO:0043488,GO:0043928,GO:0045944,GO:0070062,GO:0071028,GO:0071035,GO:0071038,GO:0071042" "3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|nuclear chromosome|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process|RNA polymerase II activating transcription factor binding|RNA binding|exoribonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|immune response|rRNA catabolic process|positive regulation of cell growth|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U1 snRNA 3'-end processing|U4 snRNA 3'-end processing|U5 snRNA 3'-end processing|mRNA 3'-UTR AU-rich region binding|regulation of mRNA stability|exonucleolytic catabolism of deadenylated mRNA|positive regulation of transcription by RNA polymerase II|extracellular exosome|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process" hsa03018 RNA degradation EXPH5 209.6842551 218.4869154 200.8815948 0.919421625 -0.121201495 0.74457053 1 0.913525941 0.825860657 23086 exophilin 5 "GO:0003334,GO:0005768,GO:0006886,GO:0031267,GO:0045921,GO:0050714,GO:0071985" keratinocyte development|endosome|intracellular protein transport|small GTPase binding|positive regulation of exocytosis|positive regulation of protein secretion|multivesicular body sorting pathway EXT1 3701.915935 3419.840432 3983.991438 1.164964131 0.220285535 0.354084979 1 22.14128333 25.36217657 2131 exostosin glycosyltransferase 1 "GO:0000139,GO:0001501,GO:0001503,GO:0001958,GO:0001974,GO:0002062,GO:0002067,GO:0002524,GO:0003128,GO:0003416,GO:0005783,GO:0005789,GO:0005794,GO:0006024,GO:0006486,GO:0007033,GO:0007165,GO:0007369,GO:0007411,GO:0007492,GO:0007498,GO:0008217,GO:0008375,GO:0008543,GO:0009615,GO:0009642,GO:0010467,GO:0014033,GO:0015012,GO:0015014,GO:0015020,GO:0016021,GO:0016757,GO:0017145,GO:0019882,GO:0021554,GO:0021772,GO:0030163,GO:0030176,GO:0030199,GO:0030210,GO:0030509,GO:0032836,GO:0033627,GO:0033692,GO:0035176,GO:0035249,GO:0035988,GO:0036022,GO:0036336,GO:0036339,GO:0042044,GO:0042060,GO:0042311,GO:0042328,GO:0042596,GO:0042803,GO:0045165,GO:0045202,GO:0046872,GO:0046982,GO:0050508,GO:0050509,GO:0050891,GO:0050901,GO:0051923,GO:0055078,GO:0060047,GO:0060070,GO:0060218,GO:0060351,GO:0060441,GO:0060506,GO:0060560,GO:0061744,GO:0061974,GO:0062094,GO:0065003,GO:0070593,GO:0071503,GO:0071625,GO:0071711,GO:0072112,GO:0072498,GO:0097021,GO:0120193,GO:1901706,GO:1904888,GO:1990823" "Golgi membrane|skeletal system development|ossification|endochondral ossification|blood vessel remodeling|chondrocyte differentiation|glandular epithelial cell differentiation|hypersensitivity|heart field specification|endochondral bone growth|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|glycosaminoglycan biosynthetic process|protein glycosylation|vacuole organization|signal transduction|gastrulation|axon guidance|endoderm development|mesoderm development|regulation of blood pressure|acetylglucosaminyltransferase activity|fibroblast growth factor receptor signaling pathway|response to virus|response to light intensity|gene expression|neural crest cell differentiation|heparan sulfate proteoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|glucuronosyltransferase activity|integral component of membrane|transferase activity, transferring glycosyl groups|stem cell division|antigen processing and presentation|optic nerve development|olfactory bulb development|protein catabolic process|integral component of endoplasmic reticulum membrane|collagen fibril organization|heparin biosynthetic process|BMP signaling pathway|glomerular basement membrane development|cell adhesion mediated by integrin|cellular polysaccharide biosynthetic process|social behavior|synaptic transmission, glutamatergic|chondrocyte proliferation|limb joint morphogenesis|dendritic cell migration|lymphocyte adhesion to endothelial cell of high endothelial venule|fluid transport|wound healing|vasodilation|heparan sulfate N-acetylglucosaminyltransferase activity|fear response|protein homodimerization activity|cell fate commitment|synapse|metal ion binding|protein heterodimerization activity|glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|multicellular organismal water homeostasis|leukocyte tethering or rolling|sulfation|sodium ion homeostasis|heart contraction|canonical Wnt signaling pathway|hematopoietic stem cell differentiation|cartilage development involved in endochondral bone morphogenesis|epithelial tube branching involved in lung morphogenesis|smoothened signaling pathway involved in lung development|developmental growth involved in morphogenesis|motor behavior|perichondral bone morphogenesis|stomach development|protein-containing complex assembly|dendrite self-avoidance|response to heparin|vocalization behavior|basement membrane organization|glomerular visceral epithelial cell differentiation|embryonic skeletal joint development|lymphocyte migration into lymphoid organs|tight junction organization|mesenchymal cell differentiation involved in bone development|cranial skeletal system development|response to leukemia inhibitory factor" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin EXT2 3424.360745 3274.182489 3574.539 1.091734811 0.126622459 0.594025005 1 45.2569546 48.58180689 2132 exostosin glycosyltransferase 2 "GO:0000139,GO:0001503,GO:0001707,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0006024,GO:0006487,GO:0007165,GO:0008217,GO:0008375,GO:0010467,GO:0015012,GO:0015014,GO:0015020,GO:0016020,GO:0016021,GO:0016757,GO:0030154,GO:0030210,GO:0033692,GO:0042044,GO:0042311,GO:0042328,GO:0042803,GO:0043541,GO:0044344,GO:0046872,GO:0046982,GO:0050508,GO:0050509,GO:0050891,GO:0051923,GO:0055078,GO:0060047,GO:0060350,GO:0070062" "Golgi membrane|ossification|mesoderm formation|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|glycosaminoglycan biosynthetic process|protein N-linked glycosylation|signal transduction|regulation of blood pressure|acetylglucosaminyltransferase activity|gene expression|heparan sulfate proteoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|glucuronosyltransferase activity|membrane|integral component of membrane|transferase activity, transferring glycosyl groups|cell differentiation|heparin biosynthetic process|cellular polysaccharide biosynthetic process|fluid transport|vasodilation|heparan sulfate N-acetylglucosaminyltransferase activity|protein homodimerization activity|UDP-N-acetylglucosamine transferase complex|cellular response to fibroblast growth factor stimulus|metal ion binding|protein heterodimerization activity|glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|multicellular organismal water homeostasis|sulfation|sodium ion homeostasis|heart contraction|endochondral bone morphogenesis|extracellular exosome" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin EXTL2 936.7843743 949.8978749 923.6708737 0.972389662 -0.040393539 0.874435037 1 16.01715758 15.31429328 2135 exostosin like glycosyltransferase 2 "GO:0001888,GO:0005515,GO:0005539,GO:0005576,GO:0005654,GO:0005783,GO:0005789,GO:0005829,GO:0006044,GO:0006486,GO:0015012,GO:0016021,GO:0019276,GO:0030145,GO:0035248,GO:0036498,GO:0047237" "glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding|glycosaminoglycan binding|extracellular region|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|N-acetylglucosamine metabolic process|protein glycosylation|heparan sulfate proteoglycan biosynthetic process|integral component of membrane|UDP-N-acetylgalactosamine metabolic process|manganese ion binding|alpha-1,4-N-acetylgalactosaminyltransferase activity|IRE1-mediated unfolded protein response|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin EXTL3 1369.539871 1359.820945 1379.258797 1.01429442 0.020476486 0.935183328 1 11.27581488 11.24561348 2137 exostosin like glycosyltransferase 3 "GO:0001888,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0006486,GO:0015012,GO:0016021,GO:0016757,GO:0030307,GO:0036498,GO:0046872" "glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein glycosylation|heparan sulfate proteoglycan biosynthetic process|integral component of membrane|transferase activity, transferring glycosyl groups|positive regulation of cell growth|IRE1-mediated unfolded protein response|metal ion binding" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin EYA3 502.0719674 526.4494246 477.6945101 0.907389177 -0.140206643 0.611661812 1 4.289410415 3.827034483 2140 EYA transcriptional coactivator and phosphatase 3 "GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005813,GO:0006302,GO:0007275,GO:0007601,GO:0009653,GO:0010212,GO:0016576,GO:0030154,GO:0035335,GO:0045739,GO:0046872,GO:0048856,GO:2001240" protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|centrosome|double-strand break repair|multicellular organism development|visual perception|anatomical structure morphogenesis|response to ionizing radiation|histone dephosphorylation|cell differentiation|peptidyl-tyrosine dephosphorylation|positive regulation of DNA repair|metal ion binding|anatomical structure development|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand EYS 4.042768641 5.202069413 2.883467868 0.554292463 -0.851280704 0.745112452 1 0.019904279 0.010848173 346007 eyes shut homolog "GO:0001750,GO:0003674,GO:0005509,GO:0005737,GO:0005815,GO:0033165,GO:0043403,GO:0050908,GO:0070062" photoreceptor outer segment|molecular_function|calcium ion binding|cytoplasm|microtubule organizing center|interphotoreceptor matrix|skeletal muscle tissue regeneration|detection of light stimulus involved in visual perception|extracellular exosome EZH1 846.2778129 844.8160727 847.7395532 1.003460493 0.004983818 0.989489538 1 9.731552146 9.601820251 2145 enhancer of zeste 1 polycomb repressive complex 2 subunit "GO:0000122,GO:0000781,GO:0003677,GO:0003682,GO:0003714,GO:0005654,GO:0006338,GO:0006348,GO:0009653,GO:0018024,GO:0021766,GO:0031493,GO:0031507,GO:0035098,GO:0045944,GO:0070734" "negative regulation of transcription by RNA polymerase II|chromosome, telomeric region|DNA binding|chromatin binding|transcription corepressor activity|nucleoplasm|chromatin remodeling|chromatin silencing at telomere|anatomical structure morphogenesis|histone-lysine N-methyltransferase activity|hippocampus development|nucleosomal histone binding|heterochromatin assembly|ESC/E(Z) complex|positive regulation of transcription by RNA polymerase II|histone H3-K27 methylation" hsa00310 Lysine degradation chromosome_remodelling_factor EZH2 919.6471133 941.5745638 897.7196629 0.953423868 -0.068810352 0.78484703 1 8.091804175 7.585820513 2146 enhancer of zeste 2 polycomb repressive complex 2 subunit "GO:0000122,GO:0000781,GO:0000785,GO:0000978,GO:0000979,GO:0001226,GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005677,GO:0005737,GO:0006306,GO:0006325,GO:0006348,GO:0006355,GO:0008284,GO:0010718,GO:0014013,GO:0014834,GO:0014898,GO:0016279,GO:0016571,GO:0018024,GO:0021695,GO:0021766,GO:0030183,GO:0031490,GO:0032355,GO:0034244,GO:0035098,GO:0035984,GO:0036333,GO:0042054,GO:0042752,GO:0043021,GO:0043406,GO:0043433,GO:0043547,GO:0045120,GO:0045605,GO:0045814,GO:0045892,GO:0046976,GO:0048387,GO:0048468,GO:0048511,GO:0051154,GO:0070301,GO:0070314,GO:0070317,GO:0070734,GO:0070878,GO:0071168,GO:0071902,GO:0097421,GO:0098532,GO:1900006,GO:1902808,GO:1904772,GO:1990841,GO:2000134" "negative regulation of transcription by RNA polymerase II|chromosome, telomeric region|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II transcription corepressor binding|chromatin binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|chromatin silencing complex|cytoplasm|DNA methylation|chromatin organization|chromatin silencing at telomere|regulation of transcription, DNA-templated|positive regulation of cell population proliferation|positive regulation of epithelial to mesenchymal transition|regulation of gliogenesis|skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration|cardiac muscle hypertrophy in response to stress|protein-lysine N-methyltransferase activity|histone methylation|histone-lysine N-methyltransferase activity|cerebellar cortex development|hippocampus development|B cell differentiation|chromatin DNA binding|response to estradiol|negative regulation of transcription elongation from RNA polymerase II promoter|ESC/E(Z) complex|cellular response to trichostatin A|hepatocyte homeostasis|histone methyltransferase activity|regulation of circadian rhythm|ribonucleoprotein complex binding|positive regulation of MAP kinase activity|negative regulation of DNA-binding transcription factor activity|positive regulation of GTPase activity|pronucleus|negative regulation of epidermal cell differentiation|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|histone methyltransferase activity (H3-K27 specific)|negative regulation of retinoic acid receptor signaling pathway|cell development|rhythmic process|negative regulation of striated muscle cell differentiation|cellular response to hydrogen peroxide|G1 to G0 transition|negative regulation of G0 to G1 transition|histone H3-K27 methylation|primary miRNA binding|protein localization to chromatin|positive regulation of protein serine/threonine kinase activity|liver regeneration|histone H3-K27 trimethylation|positive regulation of dendrite development|positive regulation of cell cycle G1/S phase transition|response to tetrachloromethane|promoter-specific chromatin binding|negative regulation of G1/S transition of mitotic cell cycle" "hsa00310,hsa05206" Lysine degradation|MicroRNAs in cancer chromosome_remodelling_factor EZR 5858.209188 5159.412444 6557.005932 1.270882296 0.34583042 0.152954871 1 88.11147505 110.1054915 7430 ezrin "GO:0000122,GO:0001650,GO:0001726,GO:0001772,GO:0001931,GO:0001951,GO:0003376,GO:0003723,GO:0003779,GO:0005515,GO:0005615,GO:0005737,GO:0005768,GO:0005829,GO:0005884,GO:0005886,GO:0005902,GO:0005903,GO:0005925,GO:0007159,GO:0007411,GO:0008017,GO:0008022,GO:0008360,GO:0008361,GO:0010628,GO:0010737,GO:0015629,GO:0016020,GO:0016323,GO:0016324,GO:0019898,GO:0019904,GO:0022612,GO:0022614,GO:0030033,GO:0030175,GO:0030315,GO:0030863,GO:0030953,GO:0031528,GO:0031532,GO:0031623,GO:0031982,GO:0032532,GO:0032587,GO:0032703,GO:0032956,GO:0032991,GO:0034236,GO:0034237,GO:0034629,GO:0036064,GO:0040018,GO:0042802,GO:0042995,GO:0043622,GO:0044297,GO:0044393,GO:0044548,GO:0044853,GO:0045177,GO:0045198,GO:0045296,GO:0046847,GO:0048015,GO:0048471,GO:0050714,GO:0050839,GO:0050860,GO:0051015,GO:0051017,GO:0051018,GO:0051117,GO:0051286,GO:0051660,GO:0061028,GO:0070062,GO:0070373,GO:0071320,GO:0071944,GO:0072659,GO:0072697,GO:0097449,GO:0097454,GO:0097718,GO:0098592,GO:1901222,GO:1902115,GO:1902896,GO:1902966,GO:1903078,GO:1903364,GO:1903753,GO:2000643" negative regulation of transcription by RNA polymerase II|fibrillar center|ruffle|immunological synapse|uropod|intestinal D-glucose absorption|sphingosine-1-phosphate receptor signaling pathway|RNA binding|actin binding|protein binding|extracellular space|cytoplasm|endosome|cytosol|actin filament|plasma membrane|microvillus|brush border|focal adhesion|leukocyte cell-cell adhesion|axon guidance|microtubule binding|protein C-terminus binding|regulation of cell shape|regulation of cell size|positive regulation of gene expression|protein kinase A signaling|actin cytoskeleton|membrane|basolateral plasma membrane|apical plasma membrane|extrinsic component of membrane|protein domain specific binding|gland morphogenesis|membrane to membrane docking|microvillus assembly|filopodium|T-tubule|cortical cytoskeleton|astral microtubule organization|microvillus membrane|actin cytoskeleton reorganization|receptor internalization|vesicle|regulation of microvillus length|ruffle membrane|negative regulation of interleukin-2 production|regulation of actin cytoskeleton organization|protein-containing complex|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|cellular protein-containing complex localization|ciliary basal body|positive regulation of multicellular organism growth|identical protein binding|cell projection|cortical microtubule organization|cell body|microspike|S100 protein binding|plasma membrane raft|apical part of cell|establishment of epithelial cell apical/basal polarity|cadherin binding|filopodium assembly|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|positive regulation of protein secretion|cell adhesion molecule binding|negative regulation of T cell receptor signaling pathway|actin filament binding|actin filament bundle assembly|protein kinase A binding|ATPase binding|cell tip|establishment of centrosome localization|establishment of endothelial barrier|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|cellular response to cAMP|cell periphery|protein localization to plasma membrane|protein localization to cell cortex|astrocyte projection|Schwann cell microvillus|disordered domain specific binding|cytoplasmic side of apical plasma membrane|regulation of NIK/NF-kappaB signaling|regulation of organelle assembly|terminal web assembly|positive regulation of protein localization to early endosome|positive regulation of protein localization to plasma membrane|positive regulation of cellular protein catabolic process|negative regulation of p38MAPK cascade|positive regulation of early endosome to late endosome transport "hsa04530,hsa04670,hsa04810,hsa04971,hsa05130,hsa05205,hsa05206" Tight junction|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Gastric acid secretion|Pathogenic Escherichia coli infection|Proteoglycans in cancer|MicroRNAs in cancer F10 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.072298147 0.098509321 2159 coagulation factor X "GO:0004252,GO:0005509,GO:0005515,GO:0005543,GO:0005576,GO:0005615,GO:0005788,GO:0005796,GO:0005886,GO:0006508,GO:0006888,GO:0007596,GO:0007598,GO:0030335,GO:0031233,GO:0051897" "serine-type endopeptidase activity|calcium ion binding|protein binding|phospholipid binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|proteolysis|endoplasmic reticulum to Golgi vesicle-mediated transport|blood coagulation|blood coagulation, extrinsic pathway|positive regulation of cell migration|intrinsic component of external side of plasma membrane|positive regulation of protein kinase B signaling" hsa04610 Complement and coagulation cascades F11R 1683.578744 1605.358621 1761.798867 1.097448785 0.134153614 0.573353867 1 18.13996169 19.57455087 50848 F11 receptor "GO:0001618,GO:0001817,GO:0005178,GO:0005515,GO:0005886,GO:0005911,GO:0005923,GO:0006954,GO:0007159,GO:0007179,GO:0008360,GO:0009314,GO:0016021,GO:0030054,GO:0030165,GO:0030198,GO:0031032,GO:0031410,GO:0032956,GO:0032991,GO:0034260,GO:0035025,GO:0035633,GO:0035683,GO:0036057,GO:0042803,GO:0043547,GO:0045296,GO:0045777,GO:0046718,GO:0050892,GO:0050900,GO:0051493,GO:0051497,GO:0070062,GO:0070160,GO:0070830,GO:0071260,GO:0072659,GO:0090557,GO:0090559,GO:0098609,GO:1901731,GO:1902396,GO:1903142,GO:2000249,GO:2000810" virus receptor activity|regulation of cytokine production|integrin binding|protein binding|plasma membrane|cell-cell junction|bicellular tight junction|inflammatory response|leukocyte cell-cell adhesion|transforming growth factor beta receptor signaling pathway|regulation of cell shape|response to radiation|integral component of membrane|cell junction|PDZ domain binding|extracellular matrix organization|actomyosin structure organization|cytoplasmic vesicle|regulation of actin cytoskeleton organization|protein-containing complex|negative regulation of GTPase activity|positive regulation of Rho protein signal transduction|maintenance of blood-brain barrier|memory T cell extravasation|slit diaphragm|protein homodimerization activity|positive regulation of GTPase activity|cadherin binding|positive regulation of blood pressure|viral entry into host cell|intestinal absorption|leukocyte migration|regulation of cytoskeleton organization|negative regulation of stress fiber assembly|extracellular exosome|tight junction|bicellular tight junction assembly|cellular response to mechanical stimulus|protein localization to plasma membrane|establishment of endothelial intestinal barrier|regulation of membrane permeability|cell-cell adhesion|positive regulation of platelet aggregation|protein localization to bicellular tight junction|positive regulation of establishment of endothelial barrier|regulation of actin cytoskeleton reorganization|regulation of bicellular tight junction assembly "hsa04514,hsa04530,hsa04670,hsa05120" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Epithelial cell signaling in Helicobacter pylori infection F12 89.18874471 95.7180772 82.65941222 0.863571591 -0.211612311 0.679127741 1 2.313540697 1.964475735 2161 coagulation factor XII "GO:0002353,GO:0002542,GO:0004252,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005791,GO:0005886,GO:0006508,GO:0007596,GO:0007597,GO:0010756,GO:0016485,GO:0016540,GO:0030194,GO:0031638,GO:0042730,GO:0045087,GO:0051787,GO:0051788,GO:0051919,GO:0062023,GO:0070062" "plasma kallikrein-kinin cascade|Factor XII activation|serine-type endopeptidase activity|calcium ion binding|protein binding|extracellular region|extracellular space|rough endoplasmic reticulum|plasma membrane|proteolysis|blood coagulation|blood coagulation, intrinsic pathway|positive regulation of plasminogen activation|protein processing|protein autoprocessing|positive regulation of blood coagulation|zymogen activation|fibrinolysis|innate immune response|misfolded protein binding|response to misfolded protein|positive regulation of fibrinolysis|collagen-containing extracellular matrix|extracellular exosome" hsa04610 Complement and coagulation cascades F2R 850.5036351 892.6751113 808.332159 0.905516631 -0.143186957 0.56876709 1 12.37735257 11.02034959 2149 coagulation factor II thrombin receptor "GO:0000186,GO:0001965,GO:0002248,GO:0003105,GO:0004930,GO:0005102,GO:0005515,GO:0005576,GO:0005769,GO:0005770,GO:0005794,GO:0005886,GO:0005887,GO:0005901,GO:0006919,GO:0006954,GO:0007186,GO:0007200,GO:0007204,GO:0007205,GO:0007529,GO:0007596,GO:0008284,GO:0008285,GO:0009611,GO:0009653,GO:0009986,GO:0014068,GO:0015057,GO:0030168,GO:0030193,GO:0030194,GO:0030335,GO:0031094,GO:0031594,GO:0031681,GO:0032496,GO:0032651,GO:0032755,GO:0032757,GO:0032967,GO:0035025,GO:0043123,GO:0043280,GO:0043410,GO:0043524,GO:0043547,GO:0045211,GO:0045217,GO:0045893,GO:0045907,GO:0045987,GO:0046427,GO:0048873,GO:0051209,GO:0051281,GO:0051482,GO:0051928,GO:0051930,GO:0060155,GO:0070374,GO:0070493,GO:0099553,GO:1900134" "activation of MAPKK activity|G-protein alpha-subunit binding|connective tissue replacement involved in inflammatory response wound healing|negative regulation of glomerular filtration|G protein-coupled receptor activity|signaling receptor binding|protein binding|extracellular region|early endosome|late endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|caveola|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|protein kinase C-activating G protein-coupled receptor signaling pathway|establishment of synaptic specificity at neuromuscular junction|blood coagulation|positive regulation of cell population proliferation|negative regulation of cell population proliferation|response to wounding|anatomical structure morphogenesis|cell surface|positive regulation of phosphatidylinositol 3-kinase signaling|thrombin-activated receptor activity|platelet activation|regulation of blood coagulation|positive regulation of blood coagulation|positive regulation of cell migration|platelet dense tubular network|neuromuscular junction|G-protein beta-subunit binding|response to lipopolysaccharide|regulation of interleukin-1 beta production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of collagen biosynthetic process|positive regulation of Rho protein signal transduction|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of MAPK cascade|negative regulation of neuron apoptotic process|positive regulation of GTPase activity|postsynaptic membrane|cell-cell junction maintenance|positive regulation of transcription, DNA-templated|positive regulation of vasoconstriction|positive regulation of smooth muscle contraction|positive regulation of receptor signaling pathway via JAK-STAT|homeostasis of number of cells within a tissue|release of sequestered calcium ion into cytosol|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|positive regulation of calcium ion transport|regulation of sensory perception of pain|platelet dense granule organization|positive regulation of ERK1 and ERK2 cascade|thrombin-activated receptor signaling pathway|trans-synaptic signaling by endocannabinoid, modulating synaptic transmission|negative regulation of renin secretion into blood stream" "hsa04015,hsa04020,hsa04024,hsa04072,hsa04080,hsa04151,hsa04610,hsa04611,hsa04810,hsa05130,hsa05200" Rap1 signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Complement and coagulation cascades|Platelet activation|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Pathways in cancer F2RL1 99.4890879 75.95021343 123.0279624 1.61985012 0.695860331 0.138414799 1 1.350207628 2.150535264 2150 F2R like trypsin receptor 1 "GO:0001965,GO:0002286,GO:0002690,GO:0002720,GO:0003104,GO:0004930,GO:0005102,GO:0005515,GO:0005769,GO:0005794,GO:0005886,GO:0005887,GO:0006954,GO:0007186,GO:0007204,GO:0007596,GO:0010804,GO:0014068,GO:0015057,GO:0030193,GO:0030335,GO:0030836,GO:0031143,GO:0031274,GO:0031681,GO:0032602,GO:0032609,GO:0032611,GO:0032613,GO:0032682,GO:0032755,GO:0032757,GO:0032930,GO:0034137,GO:0034140,GO:0034141,GO:0034145,GO:0035025,GO:0038023,GO:0042119,GO:0042311,GO:0043122,GO:0043123,GO:0043311,GO:0043547,GO:0045087,GO:0045217,GO:0045944,GO:0046328,GO:0046329,GO:0046330,GO:0050900,GO:0050921,GO:0050927,GO:0051482,GO:0051607,GO:0060100,GO:0061028,GO:0070374,GO:0070493,GO:0070661,GO:0070963,GO:0097029,GO:1900135,GO:2000341" "G-protein alpha-subunit binding|T cell activation involved in immune response|positive regulation of leukocyte chemotaxis|positive regulation of cytokine production involved in immune response|positive regulation of glomerular filtration|G protein-coupled receptor activity|signaling receptor binding|protein binding|early endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|inflammatory response|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|blood coagulation|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of phosphatidylinositol 3-kinase signaling|thrombin-activated receptor activity|regulation of blood coagulation|positive regulation of cell migration|positive regulation of actin filament depolymerization|pseudopodium|positive regulation of pseudopodium assembly|G-protein beta-subunit binding|chemokine production|interferon-gamma production|interleukin-1 beta production|interleukin-10 production|negative regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of superoxide anion generation|positive regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of Rho protein signal transduction|signaling receptor activity|neutrophil activation|vasodilation|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of eosinophil degranulation|positive regulation of GTPase activity|innate immune response|cell-cell junction maintenance|positive regulation of transcription by RNA polymerase II|regulation of JNK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|leukocyte migration|positive regulation of chemotaxis|positive regulation of positive chemotaxis|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|defense response to virus|positive regulation of phagocytosis, engulfment|establishment of endothelial barrier|positive regulation of ERK1 and ERK2 cascade|thrombin-activated receptor signaling pathway|leukocyte proliferation|positive regulation of neutrophil mediated killing of gram-negative bacterium|mature conventional dendritic cell differentiation|positive regulation of renin secretion into blood stream|regulation of chemokine (C-X-C motif) ligand 2 production" "hsa04080,hsa04750,hsa05143" Neuroactive ligand-receptor interaction|Inflammatory mediator regulation of TRP channels|African trypanosomiasis F2RL2 43.75713371 38.49531366 49.01895376 1.273374577 0.348656866 0.599642642 1 0.60459804 0.756996878 2151 coagulation factor II thrombin receptor like 2 "GO:0004435,GO:0004930,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0007186,GO:0007596,GO:0009611,GO:0015057,GO:0016324,GO:0030168,GO:0032991,GO:0035025,GO:0051482,GO:0070493" phosphatidylinositol phospholipase C activity|G protein-coupled receptor activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|blood coagulation|response to wounding|thrombin-activated receptor activity|apical plasma membrane|platelet activation|protein-containing complex|positive regulation of Rho protein signal transduction|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|thrombin-activated receptor signaling pathway "hsa04080,hsa04610" Neuroactive ligand-receptor interaction|Complement and coagulation cascades F3 15406.45887 13691.8467 17121.07104 1.250457402 0.322455911 0.221230415 1 317.9759328 390.9618042 2152 "coagulation factor III, tissue factor" "GO:0001938,GO:0002020,GO:0002541,GO:0002543,GO:0004252,GO:0004896,GO:0005515,GO:0005543,GO:0005615,GO:0005886,GO:0006919,GO:0007596,GO:0007598,GO:0009986,GO:0010628,GO:0010641,GO:0016021,GO:0016485,GO:0019221,GO:0030335,GO:0031233,GO:0032757,GO:0045766,GO:0050927,GO:0051897,GO:0062023,GO:1905286" "positive regulation of endothelial cell proliferation|protease binding|activation of plasma proteins involved in acute inflammatory response|activation of blood coagulation via clotting cascade|serine-type endopeptidase activity|cytokine receptor activity|protein binding|phospholipid binding|extracellular space|plasma membrane|activation of cysteine-type endopeptidase activity involved in apoptotic process|blood coagulation|blood coagulation, extrinsic pathway|cell surface|positive regulation of gene expression|positive regulation of platelet-derived growth factor receptor signaling pathway|integral component of membrane|protein processing|cytokine-mediated signaling pathway|positive regulation of cell migration|intrinsic component of external side of plasma membrane|positive regulation of interleukin-8 production|positive regulation of angiogenesis|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling|collagen-containing extracellular matrix|serine-type peptidase complex" "hsa04610,hsa04933" Complement and coagulation cascades|AGE-RAGE signaling pathway in diabetic complications F8 247.312762 260.1034707 234.5220533 0.901649073 -0.149362057 0.664669791 1 1.506211391 1.335348574 2157 coagulation factor VIII "GO:0000139,GO:0002576,GO:0005507,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005886,GO:0006888,GO:0006953,GO:0007596,GO:0007597,GO:0016491,GO:0030134,GO:0031093,GO:0033116,GO:0048208,GO:0055114" "Golgi membrane|platelet degranulation|copper ion binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|acute-phase response|blood coagulation|blood coagulation, intrinsic pathway|oxidoreductase activity|COPII-coated ER to Golgi transport vesicle|platelet alpha granule lumen|endoplasmic reticulum-Golgi intermediate compartment membrane|COPII vesicle coating|oxidation-reduction process" hsa04610 Complement and coagulation cascades F8A1 1302.374039 1173.58686 1431.161218 1.219476178 0.286261576 0.234361311 1 36.69137302 43.99552082 8263 coagulation factor VIII associated 1 "GO:0003674,GO:0005515,GO:0005634,GO:0005769,GO:0016604,GO:0099518,GO:1901799" molecular_function|protein binding|nucleus|early endosome|nuclear body|vesicle cytoskeletal trafficking|negative regulation of proteasomal protein catabolic process F8A2 11.52884105 12.48496659 10.57271552 0.846835707 -0.239845992 0.903809209 1 0.390333755 0.325017279 474383 coagulation factor VIII associated 2 "GO:0003674,GO:0005515,GO:0005634,GO:0005769,GO:0016604,GO:0099518,GO:1901799" molecular_function|protein binding|nucleus|early endosome|nuclear body|vesicle cytoskeletal trafficking|negative regulation of proteasomal protein catabolic process F8A3 47.60175753 38.49531366 56.7082014 1.473119609 0.558874574 0.36772984 1 1.203529079 1.743274499 474384 coagulation factor VIII associated 3 "GO:0003674,GO:0005515,GO:0005634,GO:0005769,GO:0016604,GO:0099518,GO:1901799" molecular_function|protein binding|nucleus|early endosome|nuclear body|vesicle cytoskeletal trafficking|negative regulation of proteasomal protein catabolic process FA2H 114.6593775 95.7180772 133.6006779 1.395772688 0.481064007 0.283439341 1 1.148190123 1.575794866 79152 fatty acid 2-hydroxylase "GO:0001949,GO:0005506,GO:0005515,GO:0005783,GO:0005789,GO:0006631,GO:0006633,GO:0006679,GO:0006682,GO:0016020,GO:0016021,GO:0020037,GO:0030148,GO:0030258,GO:0032286,GO:0032287,GO:0042127,GO:0042634,GO:0044857,GO:0046513,GO:0055114,GO:0061436,GO:0080132" sebaceous gland cell differentiation|iron ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|fatty acid metabolic process|fatty acid biosynthetic process|glucosylceramide biosynthetic process|galactosylceramide biosynthetic process|membrane|integral component of membrane|heme binding|sphingolipid biosynthetic process|lipid modification|central nervous system myelin maintenance|peripheral nervous system myelin maintenance|regulation of cell population proliferation|regulation of hair cycle|plasma membrane raft organization|ceramide biosynthetic process|oxidation-reduction process|establishment of skin barrier|fatty acid alpha-hydroxylase activity FAAH 4.404459729 2.080827765 6.728091692 3.233372701 1.693039812 0.389066599 1 0.054382935 0.172897848 2166 fatty acid amide hydrolase "GO:0004040,GO:0005515,GO:0005789,GO:0005856,GO:0009062,GO:0016021,GO:0017064,GO:0019369,GO:0031090,GO:0047372,GO:0052651,GO:0102077,GO:0103073" amidase activity|protein binding|endoplasmic reticulum membrane|cytoskeleton|fatty acid catabolic process|integral component of membrane|fatty acid amide hydrolase activity|arachidonic acid metabolic process|organelle membrane|acylglycerol lipase activity|monoacylglycerol catabolic process|oleamide hydrolase activity|anandamide amidohydrolase activity hsa04723 Retrograde endocannabinoid signaling FAAH2 9.086322201 11.44455271 6.728091692 0.587885946 -0.766391806 0.566347083 1 0.090525381 0.052328058 158584 fatty acid amide hydrolase 2 "GO:0005811,GO:0016021,GO:0016042,GO:0017064,GO:0019369,GO:0102077,GO:0103073" lipid droplet|integral component of membrane|lipid catabolic process|fatty acid amide hydrolase activity|arachidonic acid metabolic process|oleamide hydrolase activity|anandamide amidohydrolase activity FAAP100 472.0729575 533.7323218 410.4135932 0.768950233 -0.379037866 0.171229553 1 7.509705525 5.677959873 80233 FA core complex associated protein 100 "GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0036297,GO:0043240" DNA binding|protein binding|nucleoplasm|cytosol|interstrand cross-link repair|Fanconi anaemia nuclear complex hsa03460 Fanconi anemia pathway FAAP20 975.7759716 888.5134558 1063.038487 1.196423622 0.258728301 0.294119396 1 8.955303138 10.53504631 199990 FA core complex associated protein 20 "GO:0005515,GO:0005654,GO:0005694,GO:0006974,GO:0016604,GO:0019985,GO:0030054,GO:0031593,GO:0036297,GO:0043130,GO:0043240,GO:0046872,GO:0070530,GO:0140036" protein binding|nucleoplasm|chromosome|cellular response to DNA damage stimulus|nuclear body|translesion synthesis|cell junction|polyubiquitin modification-dependent protein binding|interstrand cross-link repair|ubiquitin binding|Fanconi anaemia nuclear complex|metal ion binding|K63-linked polyubiquitin modification-dependent protein binding|ubiquitin-dependent protein binding FAAP24 151.4405849 152.9408407 149.9403291 0.980381227 -0.028585236 0.961558249 1 3.483641305 3.358146175 91442 FA core complex associated protein 24 "GO:0003677,GO:0003682,GO:0005515,GO:0005654,GO:0036297,GO:0043231,GO:0043240" DNA binding|chromatin binding|protein binding|nucleoplasm|interstrand cross-link repair|intracellular membrane-bounded organelle|Fanconi anaemia nuclear complex hsa03460 Fanconi anemia pathway FABP4 19.85718253 16.64662212 23.06774294 1.385731158 0.470647391 0.614924015 1 0.975191688 1.328740435 2167 fatty acid binding protein 4 "GO:0005324,GO:0005504,GO:0005634,GO:0005737,GO:0005811,GO:0005829,GO:0006469,GO:0009617,GO:0015909,GO:0019433,GO:0036041,GO:0042632,GO:0045892,GO:0050729,GO:0050872,GO:0050873,GO:0051427,GO:0070062,GO:0071285,GO:0071356,GO:0120162" "long-chain fatty acid transporter activity|fatty acid binding|nucleus|cytoplasm|lipid droplet|cytosol|negative regulation of protein kinase activity|response to bacterium|long-chain fatty acid transport|triglyceride catabolic process|long-chain fatty acid binding|cholesterol homeostasis|negative regulation of transcription, DNA-templated|positive regulation of inflammatory response|white fat cell differentiation|brown fat cell differentiation|hormone receptor binding|extracellular exosome|cellular response to lithium ion|cellular response to tumor necrosis factor|positive regulation of cold-induced thermogenesis" "hsa03320,hsa04923" PPAR signaling pathway|Regulation of lipolysis in adipocytes FABP5 1137.690507 988.3931885 1286.987825 1.302101067 0.380841432 0.117329529 1 78.03066255 99.90360679 2171 fatty acid binding protein 5 "GO:0001972,GO:0005324,GO:0005504,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006006,GO:0006629,GO:0006656,GO:0008289,GO:0008544,GO:0010829,GO:0014069,GO:0015909,GO:0019433,GO:0030667,GO:0031392,GO:0035360,GO:0035578,GO:0042593,GO:0042802,GO:0043312,GO:0045202,GO:0051930,GO:0070062,GO:0099178,GO:0120162,GO:1990379" retinoic acid binding|long-chain fatty acid transporter activity|fatty acid binding|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|glucose metabolic process|lipid metabolic process|phosphatidylcholine biosynthetic process|lipid binding|epidermis development|negative regulation of glucose transmembrane transport|postsynaptic density|long-chain fatty acid transport|triglyceride catabolic process|secretory granule membrane|regulation of prostaglandin biosynthetic process|positive regulation of peroxisome proliferator activated receptor signaling pathway|azurophil granule lumen|glucose homeostasis|identical protein binding|neutrophil degranulation|synapse|regulation of sensory perception of pain|extracellular exosome|regulation of retrograde trans-synaptic signaling by endocanabinoid|positive regulation of cold-induced thermogenesis|lipid transport across blood-brain barrier hsa03320 PPAR signaling pathway FABP6 27.90309085 26.01034707 29.79583464 1.145537757 0.196025011 0.836744282 1 1.800420776 2.02793767 2172 fatty acid binding protein 6 "GO:0005737,GO:0005829,GO:0006629,GO:0006869,GO:0008285,GO:0008289,GO:0016020,GO:0019433" cytoplasm|cytosol|lipid metabolic process|lipid transport|negative regulation of cell population proliferation|lipid binding|membrane|triglyceride catabolic process hsa03320 PPAR signaling pathway FADD 691.4140459 639.8545378 742.973554 1.161160092 0.215566894 0.402449051 1 19.99289267 22.82647836 8772 Fas associated via death domain "GO:0001822,GO:0001916,GO:0002020,GO:0002821,GO:0005123,GO:0005164,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006915,GO:0006919,GO:0007166,GO:0008625,GO:0016032,GO:0031264,GO:0031265,GO:0032729,GO:0032757,GO:0032760,GO:0032813,GO:0033077,GO:0033612,GO:0034138,GO:0035666,GO:0035877,GO:0036462,GO:0042104,GO:0042802,GO:0043005,GO:0043029,GO:0043065,GO:0043123,GO:0043278,GO:0044297,GO:0044877,GO:0045087,GO:0045121,GO:0045651,GO:0045862,GO:0045944,GO:0048148,GO:0048535,GO:0048536,GO:0048538,GO:0051607,GO:0060340,GO:0060546,GO:0070236,GO:0071260,GO:0071550,GO:0089720,GO:0097049,GO:0097190,GO:0097191,GO:0097192,GO:0097202,GO:0097342,GO:0097527,GO:1902041,GO:1902042,GO:2000454,GO:2001238" "kidney development|positive regulation of T cell mediated cytotoxicity|protease binding|positive regulation of adaptive immune response|death receptor binding|tumor necrosis factor receptor binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell surface receptor signaling pathway|extrinsic apoptotic signaling pathway via death domain receptors|viral process|death-inducing signaling complex|CD95 death-inducing signaling complex|positive regulation of interferon-gamma production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|tumor necrosis factor receptor superfamily binding|T cell differentiation in thymus|receptor serine/threonine kinase binding|toll-like receptor 3 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|death effector domain binding|TRAIL-activated apoptotic signaling pathway|positive regulation of activated T cell proliferation|identical protein binding|neuron projection|T cell homeostasis|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to morphine|cell body|protein-containing complex binding|innate immune response|membrane raft|positive regulation of macrophage differentiation|positive regulation of proteolysis|positive regulation of transcription by RNA polymerase II|behavioral response to cocaine|lymph node development|spleen development|thymus development|defense response to virus|positive regulation of type I interferon-mediated signaling pathway|negative regulation of necroptotic process|negative regulation of activation-induced cell death of T cells|cellular response to mechanical stimulus|death-inducing signaling complex assembly|caspase binding|motor neuron apoptotic process|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|activation of cysteine-type endopeptidase activity|ripoptosome|necroptotic signaling pathway|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation|positive regulation of extrinsic apoptotic signaling pathway" "hsa01524,hsa04210,hsa04215,hsa04217,hsa04620,hsa04621,hsa04622,hsa04657,hsa04668,hsa05010,hsa05022,hsa05130,hsa05132,hsa05142,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200" Platinum drug resistance|Apoptosis|Apoptosis - multiple species|Necroptosis|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection|Chagas disease|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer FADS1 2644.618501 2788.309205 2500.927797 0.896933451 -0.156927149 0.507329071 1 32.76964052 28.90034831 3992 fatty acid desaturase 1 "GO:0000248,GO:0005739,GO:0005789,GO:0006355,GO:0006636,GO:0007267,GO:0008654,GO:0009267,GO:0016020,GO:0016021,GO:0016213,GO:0016491,GO:0019216,GO:0036109,GO:0042759,GO:0043231,GO:0043651,GO:0045485,GO:0045595,GO:0046456,GO:0055114,GO:0062076" "C-5 sterol desaturase activity|mitochondrion|endoplasmic reticulum membrane|regulation of transcription, DNA-templated|unsaturated fatty acid biosynthetic process|cell-cell signaling|phospholipid biosynthetic process|cellular response to starvation|membrane|integral component of membrane|linoleoyl-CoA desaturase activity|oxidoreductase activity|regulation of lipid metabolic process|alpha-linolenic acid metabolic process|long-chain fatty acid biosynthetic process|intracellular membrane-bounded organelle|linoleic acid metabolic process|omega-6 fatty acid desaturase activity|regulation of cell differentiation|icosanoid biosynthetic process|oxidation-reduction process|acyl-CoA delta5-desaturase activity" hsa01040 Biosynthesis of unsaturated fatty acids FADS2 533.6114764 572.2276355 494.9953173 0.865032177 -0.209174296 0.439365381 1 8.518476205 7.245449865 9415 fatty acid desaturase 2 "GO:0004768,GO:0005789,GO:0005887,GO:0006636,GO:0016020,GO:0016213,GO:0036109,GO:0043651,GO:0055114" stearoyl-CoA 9-desaturase activity|endoplasmic reticulum membrane|integral component of plasma membrane|unsaturated fatty acid biosynthetic process|membrane|linoleoyl-CoA desaturase activity|alpha-linolenic acid metabolic process|linoleic acid metabolic process|oxidation-reduction process "hsa00592,hsa01040,hsa03320" alpha-Linolenic acid metabolism|Biosynthesis of unsaturated fatty acids|PPAR signaling pathway FADS3 2062.726545 2172.384187 1953.068903 0.899043969 -0.15353642 0.516906492 1 53.10863554 46.94801715 3995 fatty acid desaturase 3 "GO:0003674,GO:0005515,GO:0005789,GO:0006636,GO:0006665,GO:0016020,GO:0016021,GO:0016491,GO:0055114" molecular_function|protein binding|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|sphingolipid metabolic process|membrane|integral component of membrane|oxidoreductase activity|oxidation-reduction process FAF1 1486.122789 1253.698729 1718.546849 1.370781361 0.45499848 0.056812865 1 9.959451763 13.42377925 11124 Fas associated factor 1 "GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005829,GO:0006915,GO:0007253,GO:0008219,GO:0010942,GO:0019887,GO:0019901,GO:0019904,GO:0030155,GO:0031072,GO:0031265,GO:0031334,GO:0031625,GO:0034098,GO:0042176,GO:0043065,GO:0043130,GO:0043161,GO:0045740,GO:0045859,GO:0048471,GO:0051059,GO:1902043,GO:1903364" protein binding|nucleus|nuclear envelope|nucleoplasm|cytosol|apoptotic process|cytoplasmic sequestering of NF-kappaB|cell death|positive regulation of cell death|protein kinase regulator activity|protein kinase binding|protein domain specific binding|regulation of cell adhesion|heat shock protein binding|CD95 death-inducing signaling complex|positive regulation of protein-containing complex assembly|ubiquitin protein ligase binding|VCP-NPL4-UFD1 AAA ATPase complex|regulation of protein catabolic process|positive regulation of apoptotic process|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of DNA replication|regulation of protein kinase activity|perinuclear region of cytoplasm|NF-kappaB binding|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of cellular protein catabolic process hsa04217 Necroptosis FAF2 2505.960408 2617.681329 2394.239486 0.914641313 -0.128722011 0.586755501 1 30.75756086 27.66138264 23197 Fas associated factor family member 2 "GO:0005515,GO:0005576,GO:0005783,GO:0005811,GO:0006986,GO:0030433,GO:0030970,GO:0031625,GO:0034098,GO:0034389,GO:0035473,GO:0035578,GO:0043086,GO:0043130,GO:0043312,GO:0055102" "protein binding|extracellular region|endoplasmic reticulum|lipid droplet|response to unfolded protein|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|ubiquitin protein ligase binding|VCP-NPL4-UFD1 AAA ATPase complex|lipid droplet organization|lipase binding|azurophil granule lumen|negative regulation of catalytic activity|ubiquitin binding|neutrophil degranulation|lipase inhibitor activity" FAH 976.498125 1084.111266 868.8849842 0.801472147 -0.31927571 0.194971269 1 38.34130268 30.21526986 2184 fumarylacetoacetate hydrolase "GO:0004334,GO:0005515,GO:0005829,GO:0006527,GO:0006559,GO:0006572,GO:0046872,GO:0070062,GO:1902000" fumarylacetoacetase activity|protein binding|cytosol|arginine catabolic process|L-phenylalanine catabolic process|tyrosine catabolic process|metal ion binding|extracellular exosome|homogentisate catabolic process hsa00350 Tyrosine metabolism FAHD1 387.3383623 416.1655531 358.5111716 0.86146287 -0.215139479 0.463813127 1 8.079298176 6.84354896 81889 fumarylacetoacetate hydrolase domain containing 1 "GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0006099,GO:0008948,GO:0018773,GO:0034545,GO:0046872,GO:0047621" nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|tricarboxylic acid cycle|oxaloacetate decarboxylase activity|acetylpyruvate hydrolase activity|fumarylpyruvate hydrolase activity|metal ion binding|acylpyruvate hydrolase activity hsa00350 Tyrosine metabolism FAHD2A 534.4788976 506.6815608 562.2762343 1.109723104 0.150199742 0.580573325 1 5.296897877 5.779728077 51011 fumarylacetoacetate hydrolase domain containing 2A "GO:0005515,GO:0016787,GO:0016836,GO:0046872" protein binding|hydrolase activity|hydro-lyase activity|metal ion binding FAHD2B 191.4323528 193.5169822 189.3477233 0.978455334 -0.031422102 0.947500481 1 2.611948829 2.512909498 151313 fumarylacetoacetate hydrolase domain containing 2B "GO:0016787,GO:0016836,GO:0046872" hydrolase activity|hydro-lyase activity|metal ion binding FAIM 57.08436936 60.34400519 53.82473354 0.891964883 -0.164941183 0.798718307 1 1.406309454 1.23338832 55179 Fas apoptotic inhibitory molecule "GO:0005515,GO:0005737,GO:0006915,GO:0007249,GO:0050769,GO:1902042" protein binding|cytoplasm|apoptotic process|I-kappaB kinase/NF-kappaB signaling|positive regulation of neurogenesis|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors FAM102A 1445.405796 1522.12551 1368.686081 0.899193971 -0.153295733 0.52245238 1 17.04070504 15.06649126 399665 family with sequence similarity 102 member A GO:0005515 protein binding FAM102B 1089.64277 963.4232553 1215.862284 1.262022977 0.335738176 0.168922705 1 9.207759391 11.42595219 284611 family with sequence similarity 102 member B FAM104A 1232.565701 1283.870731 1181.26067 0.920077576 -0.120172589 0.620711739 1 20.43478117 18.48696488 84923 family with sequence similarity 104 member A GO:0005515 protein binding FAM104B 236.9136536 226.8102264 247.0170807 1.08909146 0.123125115 0.727739225 1 3.230436329 3.459367627 90736 family with sequence similarity 104 member B FAM107A 4.444088692 3.121241648 5.766935736 1.847641543 0.88568489 0.705170935 1 0.042138864 0.076554676 11170 family with sequence similarity 107 member A "GO:0001558,GO:0001725,GO:0003674,GO:0003779,GO:0005515,GO:0005634,GO:0005737,GO:0005925,GO:0007049,GO:0015629,GO:0016607,GO:0030041,GO:0030335,GO:0031398,GO:0031647,GO:0031669,GO:0032587,GO:0032956,GO:0043005,GO:0045202,GO:0050890,GO:0051017,GO:0051895,GO:0070507,GO:0071385,GO:1900272,GO:2000134" regulation of cell growth|stress fiber|molecular_function|actin binding|protein binding|nucleus|cytoplasm|focal adhesion|cell cycle|actin cytoskeleton|nuclear speck|actin filament polymerization|positive regulation of cell migration|positive regulation of protein ubiquitination|regulation of protein stability|cellular response to nutrient levels|ruffle membrane|regulation of actin cytoskeleton organization|neuron projection|synapse|cognition|actin filament bundle assembly|negative regulation of focal adhesion assembly|regulation of microtubule cytoskeleton organization|cellular response to glucocorticoid stimulus|negative regulation of long-term synaptic potentiation|negative regulation of G1/S transition of mitotic cell cycle FAM107B 1155.525383 1153.818996 1157.231771 1.002957808 0.004260917 0.990070111 1 11.90127545 11.73673636 83641 family with sequence similarity 107 member B FAM110A 395.9591978 390.155206 401.7631896 1.02975222 0.042297237 0.892826492 1 7.260064947 7.350966125 83541 family with sequence similarity 110 member A "GO:0000922,GO:0005515,GO:0005737,GO:0005815" spindle pole|protein binding|cytoplasm|microtubule organizing center FAM110B 55.0035416 56.18234966 53.82473354 0.958036356 -0.06184769 0.948716076 1 0.457204749 0.43068912 90362 family with sequence similarity 110 member B "GO:0005515,GO:0005739,GO:0005815,GO:0005829" protein binding|mitochondrion|microtubule organizing center|cytosol FAM111A 1683.186256 1784.309809 1582.062704 0.886652472 -0.173559351 0.465643602 1 22.83581177 19.90861566 63901 FAM111 trypsin like peptidase A "GO:0000785,GO:0001650,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006260,GO:0006508,GO:0006974,GO:0008233,GO:0016032,GO:0016540,GO:0031297,GO:0045071,GO:0106300" chromatin|fibrillar center|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|DNA replication|proteolysis|cellular response to DNA damage stimulus|peptidase activity|viral process|protein autoprocessing|replication fork processing|negative regulation of viral genome replication|protein-DNA covalent cross-linking repair FAM111B 381.1059399 378.7106533 383.5012264 1.012649692 0.018135186 0.960545635 1 5.76471521 5.739952131 374393 FAM111 trypsin like peptidase B "GO:0000785,GO:0005515,GO:0005634,GO:0006260,GO:0006508,GO:0008233" chromatin|protein binding|nucleus|DNA replication|proteolysis|peptidase activity FAM114A1 2848.503065 2690.510301 3006.49583 1.11744446 0.160203128 0.498734652 1 21.72278212 23.86780998 92689 family with sequence similarity 114 member A1 "GO:0005515,GO:0005654,GO:0005794,GO:0005829" protein binding|nucleoplasm|Golgi apparatus|cytosol FAM114A2 358.8905268 350.6194785 367.1615752 1.047179629 0.066508937 0.832079019 1 2.679255033 2.758712349 10827 family with sequence similarity 114 member A2 "GO:0005515,GO:0005575,GO:0008150,GO:0017076" protein binding|cellular_component|biological_process|purine nucleotide binding FAM117A 204.1601235 212.2444321 196.075815 0.923820772 -0.11431511 0.762128731 1 3.376183383 3.066796293 81558 family with sequence similarity 117 member A FAM117B 273.135025 281.9521622 264.3178879 0.937456503 -0.093176343 0.783958446 1 2.515424388 2.318641324 150864 family with sequence similarity 117 member B GO:0005515 protein binding FAM118A 464.8001212 494.1965943 435.4036481 0.881033283 -0.182731573 0.5142811 1 4.327923193 3.749238247 55007 family with sequence similarity 118 member A "GO:0005515,GO:0016021,GO:0042802" protein binding|integral component of membrane|identical protein binding FAM118B 425.6506224 450.4992112 400.8020336 0.889684207 -0.168634751 0.557143425 1 9.893956757 8.655199208 79607 family with sequence similarity 118 member B "GO:0005515,GO:0015030,GO:0030576,GO:0042802" protein binding|Cajal body|Cajal body organization|identical protein binding FAM120A 5220.525642 5349.808185 5091.243099 0.951668345 -0.071469211 0.766852116 1 30.06945027 28.13729154 23196 family with sequence similarity 120A "GO:0003723,GO:0005634,GO:0005829,GO:0005886,GO:0016020" RNA binding|nucleus|cytosol|plasma membrane|membrane FAM120AOS 670.6246612 750.1384094 591.1109129 0.788002461 -0.343727959 0.182588059 1 6.213488781 4.814312432 158293 family with sequence similarity 120A opposite strand GO:0005515 protein binding FAM120B 622.6517661 638.8141239 606.4894082 0.949398871 -0.07491376 0.779302055 1 4.40697204 4.113961138 84498 family with sequence similarity 120B "GO:0005515,GO:0005634,GO:0035357,GO:0045444" protein binding|nucleus|peroxisome proliferator activated receptor signaling pathway|fat cell differentiation FAM120C 309.7878991 260.1034707 359.4723275 1.382035875 0.466795065 0.134185204 1 1.639646135 2.228130506 54954 family with sequence similarity 120C "GO:0003723,GO:0005634" RNA binding|nucleus FAM124A 23.74143532 17.687036 29.79583464 1.684614348 0.752418359 0.355893076 1 0.148860527 0.246576241 220108 family with sequence similarity 124 member A GO:0005515 protein binding FAM126A 2248.975721 2507.397457 1990.553985 0.793872539 -0.333020703 0.158907552 1 9.680618816 7.556576399 84668 family with sequence similarity 126 member A "GO:0005515,GO:0005829,GO:0005886,GO:0042552,GO:0046854,GO:0072659" protein binding|cytosol|plasma membrane|myelination|phosphatidylinositol phosphorylation|protein localization to plasma membrane FAM126B 506.9324674 490.0349387 523.829996 1.068964587 0.09621406 0.729464899 1 2.436168052 2.560599994 285172 family with sequence similarity 126 member B "GO:0005515,GO:0005829,GO:0005886,GO:0046854,GO:0072659" protein binding|cytosol|plasma membrane|phosphatidylinositol phosphorylation|protein localization to plasma membrane FAM131A 533.3837635 541.015219 525.7523079 0.971788389 -0.0412859 0.885068276 1 10.1451117 9.693926381 131408 family with sequence similarity 131 member A FAM131B 7.406814487 5.202069413 9.61155956 1.847641543 0.88568489 0.555147706 1 0.055826439 0.101421219 9715 family with sequence similarity 131 member B "GO:0005515,GO:0005654,GO:0005829" protein binding|nucleoplasm|cytosol FAM131C 70.65440922 75.95021343 65.35860501 0.860545376 -0.216676828 0.700601251 1 2.356583314 1.994011931 348487 family with sequence similarity 131 member C GO:0005515 protein binding FAM133A 74.83115601 46.81862472 102.8436873 2.196640502 1.13529878 0.029544587 0.889916791 0.624499863 1.348846449 286499 family with sequence similarity 133 member A GO:0005515 protein binding FAM133B 233.381031 247.6185041 219.143558 0.885004773 -0.176242859 0.614650622 1 4.482681295 3.900808717 257415 family with sequence similarity 133 member B GO:0003723 RNA binding FAM135A 268.0417817 299.6391982 236.4443652 0.789096909 -0.341725606 0.297648863 1 2.466634782 1.913843283 57579 family with sequence similarity 135 member A GO:0044255 cellular lipid metabolic process FAM136A 619.7437605 600.3188103 639.1687107 1.064715448 0.090467912 0.733971595 1 13.91138149 14.56380965 84908 family with sequence similarity 136 member A "GO:0005515,GO:0005737" protein binding|cytoplasm FAM13A 415.3502792 470.267075 360.4334835 0.766444224 -0.383747287 0.180067815 1 2.194586348 1.65388157 10144 family with sequence similarity 13 member A "GO:0005096,GO:0005829,GO:0007165,GO:0043547,GO:0051056" GTPase activator activity|cytosol|signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction FAM13B 486.4707896 482.7520415 490.1895376 1.015406452 0.022057332 0.944165502 1 4.134080423 4.127527905 51306 family with sequence similarity 13 member B "GO:0005096,GO:0005829,GO:0007165,GO:0043547,GO:0051056" GTPase activator activity|cytosol|signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction FAM13C 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.033836061 0 220965 family with sequence similarity 13 member C GO:0005515 protein binding FAM149A 87.46960803 88.43518002 86.50403604 0.97816317 -0.03185295 0.9741862 1 0.704421346 0.677508882 25854 family with sequence similarity 149 member A FAM149B1 699.6675455 730.3705456 668.9645454 0.915924868 -0.126698834 0.624133031 1 6.775340458 6.10185878 317662 family with sequence similarity 149 member B1 "GO:0005515,GO:0005929,GO:0060271,GO:0061512" protein binding|cilium|cilium assembly|protein localization to cilium FAM151B 16.73091047 22.88910542 10.57271552 0.461910386 -1.11431511 0.229652802 1 0.331852618 0.150721134 167555 family with sequence similarity 151 member B GO:0005515 protein binding FAM155A 52.77425882 22.88910542 82.65941222 3.61129938 1.852518026 0.002315743 0.310468473 0.134531882 0.477705113 728215 family with sequence similarity 155 member A "GO:0005886,GO:0015275,GO:0016021,GO:0098703" "plasma membrane|stretch-activated, cation-selective, calcium channel activity|integral component of membrane|calcium ion import across plasma membrane" FAM156A 13.53041089 14.56579436 12.49502743 0.857833574 -0.221230314 0.898154764 1 0.14546214 0.122694244 29057 family with sequence similarity 156 member A "GO:0005515,GO:0005635,GO:0016021,GO:0035064" protein binding|nuclear envelope|integral component of membrane|methylated histone binding FAM156B 6.524916457 7.282897178 5.766935736 0.791846376 -0.336707531 0.922510643 1 0.09280679 0.072258986 727866 family with sequence similarity 156 member B "GO:0005515,GO:0005635,GO:0016021,GO:0035064" protein binding|nuclear envelope|integral component of membrane|methylated histone binding FAM161A 305.155112 327.730373 282.5798511 0.86223272 -0.213850783 0.498436134 1 4.356255957 3.69325307 84140 FAM161 centrosomal protein A "GO:0000235,GO:0001917,GO:0005515,GO:0005813,GO:0005876,GO:0005929,GO:0007601,GO:0008017,GO:0032391,GO:0036064,GO:0042802,GO:0044782,GO:0050896,GO:0060271,GO:0072686,GO:0097431,GO:1901985" astral microtubule|photoreceptor inner segment|protein binding|centrosome|spindle microtubule|cilium|visual perception|microtubule binding|photoreceptor connecting cilium|ciliary basal body|identical protein binding|cilium organization|response to stimulus|cilium assembly|mitotic spindle|mitotic spindle pole|positive regulation of protein acetylation FAM161B 118.2957957 115.485941 121.1056505 1.048661417 0.068548947 0.895918509 1 1.454631205 1.499889855 145483 FAM161 centrosomal protein B "GO:0005515,GO:0005881,GO:0005929,GO:0008150,GO:0015630,GO:0044782" protein binding|cytoplasmic microtubule|cilium|biological_process|microtubule cytoskeleton|cilium organization FAM162A 590.3498603 497.3178359 683.3818847 1.374135081 0.458523832 0.082180448 1 8.696244715 11.74985097 26355 family with sequence similarity 162 member A "GO:0005515,GO:0005739,GO:0005829,GO:0006919,GO:0016021,GO:0043065,GO:0051402,GO:0071456,GO:0090200" protein binding|mitochondrion|cytosol|activation of cysteine-type endopeptidase activity involved in apoptotic process|integral component of membrane|positive regulation of apoptotic process|neuron apoptotic process|cellular response to hypoxia|positive regulation of release of cytochrome c from mitochondria FAM166A 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.037090833 0.101075696 401565 family with sequence similarity 166 member A "GO:0005515,GO:0005634,GO:0036064" protein binding|nucleus|ciliary basal body FAM166B 5.122811487 8.323311061 1.922311912 0.230955193 -2.11431511 0.224307997 1 0.435917383 0.098992684 730112 family with sequence similarity 166 member B FAM166C 2.561405743 4.161655531 0.961155956 0.230955193 -2.11431511 0.482263142 1 0.050765693 0.011528405 339778 family with sequence similarity 166 member C GO:0005634 nucleus FAM167A 2812.20305 2532.36739 3092.03871 1.221007158 0.288071658 0.22340732 1 25.23768316 30.29973794 83648 family with sequence similarity 167 member A GO:0005515 protein binding FAM167B 7.847763501 4.161655531 11.53387147 2.771462315 1.470647391 0.277893468 1 0.234529997 0.639114328 84734 family with sequence similarity 167 member B FAM168A 2503.365018 2499.074146 2507.655889 1.003433969 0.004945683 0.985221643 1 18.47499572 18.22822262 23201 family with sequence similarity 168 member A "GO:0005515,GO:1905053" protein binding|positive regulation of base-excision repair FAM168B 2943.045522 3116.039579 2770.051465 0.88896543 -0.169800777 0.473406016 1 25.87479466 22.61689403 130074 family with sequence similarity 168 member B "GO:0005886,GO:0016021,GO:0030424,GO:0048471,GO:0070062" plasma membrane|integral component of membrane|axon|perinuclear region of cytoplasm|extracellular exosome FAM169A 392.2183696 430.7313474 353.7053918 0.821174019 -0.284240111 0.329541119 1 2.801967377 2.26240032 26049 family with sequence similarity 169 member A "GO:0005515,GO:0005637" protein binding|nuclear inner membrane FAM171A1 1350.058242 1504.438474 1195.678009 0.794766971 -0.331396177 0.167381978 1 16.5852337 12.96082314 221061 family with sequence similarity 171 member A1 "GO:0005515,GO:0005886,GO:0008360,GO:0016021,GO:0043149" protein binding|plasma membrane|regulation of cell shape|integral component of membrane|stress fiber assembly FAM171A2 317.0261369 286.1138177 347.9384561 1.21608407 0.282242969 0.363801279 1 4.631291658 5.537795449 284069 family with sequence similarity 171 member A2 GO:0016021 integral component of membrane FAM171B 770.3515228 832.3311061 708.3719396 0.851069886 -0.232650491 0.358291526 1 7.750825576 6.486110841 165215 family with sequence similarity 171 member B GO:0016021 integral component of membrane FAM172A 407.2603259 371.4277561 443.0928957 1.19294503 0.254527566 0.378482773 1 0.528231538 0.619606461 83989 family with sequence similarity 172 member A "GO:0000381,GO:0005515,GO:0005634,GO:0005783,GO:0006397,GO:0008380,GO:0014032,GO:0031048,GO:0035197" "regulation of alternative mRNA splicing, via spliceosome|protein binding|nucleus|endoplasmic reticulum|mRNA processing|RNA splicing|neural crest cell development|heterochromatin assembly by small RNA|siRNA binding" FAM174A 299.1013271 244.4972624 353.7053918 1.446664017 0.5327299 0.090773155 1 9.510473417 13.52823049 345757 family with sequence similarity 174 member A "GO:0005515,GO:0016021" protein binding|integral component of membrane FAM174B 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.021322956 0.058106881 400451 family with sequence similarity 174 member B "GO:0005794,GO:0005886,GO:0007030,GO:0016021" Golgi apparatus|plasma membrane|Golgi organization|integral component of membrane FAM174C 273.8930058 289.2350594 258.5509522 0.893912905 -0.16179382 0.625158581 1 17.74246382 15.59481812 55009 family with sequence similarity 174 member C "GO:0005576,GO:0005737,GO:0016021" extracellular region|cytoplasm|integral component of membrane FAM177A1 914.8469784 828.1694506 1001.524506 1.209323171 0.274199832 0.269118051 1 13.05312506 15.52129852 283635 family with sequence similarity 177 member A1 FAM180A 2.962725795 2.080827765 3.844623824 1.847641543 0.88568489 0.829811711 1 0.021613459 0.039265685 389558 family with sequence similarity 180 member A GO:0005576 extracellular region FAM183A 50.2424212 44.73779695 55.74704545 1.246083832 0.317401131 0.614852871 1 0.662478912 0.811690565 440585 family with sequence similarity 183 member A GO:0097546 ciliary base FAM184A 120.8572015 119.6475965 122.0668064 1.020219461 0.028879526 0.968475608 1 1.527966576 1.532775805 79632 family with sequence similarity 184 member A "GO:0003674,GO:0005515,GO:0005615,GO:0008150" molecular_function|protein binding|extracellular space|biological_process FAM185A 108.1294307 100.9201466 115.3387147 1.142871058 0.192662644 0.686170006 1 2.733970935 3.072290702 222234 family with sequence similarity 185 member A GO:0005515 protein binding FAM186B 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.042580504 0.012892835 84070 family with sequence similarity 186 member B GO:0032991 protein-containing complex FAM189A2 23.26085734 17.687036 28.83467868 1.63027195 0.705112644 0.393311735 1 0.263518873 0.422418529 9413 family with sequence similarity 189 member A2 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane FAM189B 1336.123324 1201.678034 1470.568613 1.223762581 0.291323691 0.225364672 1 20.10387088 24.19067765 10712 family with sequence similarity 189 member B "GO:0005515,GO:0008150,GO:0016021,GO:0050699" protein binding|biological_process|integral component of membrane|WW domain binding FAM193A 645.8975322 693.9560597 597.8390046 0.861494033 -0.215087291 0.408617461 1 5.984996682 5.069759601 8603 family with sequence similarity 193 member A FAM193B 504.85667 473.3883166 536.3250234 1.13294943 0.180083467 0.512059971 1 5.713221259 6.364477381 54540 family with sequence similarity 193 member B "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0016607" protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|nuclear speck FAM199X 4033.154393 4015.997587 4050.311199 1.008544231 0.012274357 0.960030422 1 28.59591863 28.35764626 139231 "family with sequence similarity 199, X-linked" GO:0005515 protein binding FAM200A 142.958758 132.1325631 153.784953 1.163868689 0.218928298 0.605529449 1 2.071584031 2.370706104 221786 family with sequence similarity 200 member A "GO:0005515,GO:0016021" protein binding|integral component of membrane FAM200B 448.7579943 451.5396251 445.9763636 0.98767935 -0.017885347 0.957865438 1 5.133753706 4.985654533 285550 family with sequence similarity 200 member B FAM204A 368.2297141 330.8516147 405.6078134 1.225950835 0.293901124 0.322235147 1 1.254222375 1.511885064 63877 family with sequence similarity 204 member A GO:0005515 protein binding FAM207A 480.2779961 446.3375557 514.2184365 1.152084179 0.204246134 0.461765546 1 14.52452135 16.45345928 85395 family with sequence similarity 207 member A "GO:0000462,GO:0005515,GO:0005730,GO:0030686,GO:0030688" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|protein binding|nucleolus|90S preribosome|preribosome, small subunit precursor" FAM209A 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.167496159 0.228220689 200232 family with sequence similarity 209 member A "GO:0003674,GO:0005515,GO:0005634,GO:0008150,GO:0016021,GO:0070062" molecular_function|protein binding|nucleus|biological_process|integral component of membrane|extracellular exosome FAM209B 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.137665232 0.208416415 388799 family with sequence similarity 209 member B "GO:0005634,GO:0016021" nucleus|integral component of membrane FAM20A 4.523346619 5.202069413 3.844623824 0.739056617 -0.436243205 0.933440272 1 0.028349319 0.020601153 54757 FAM20A golgi associated secretory pathway pseudokinase "GO:0001934,GO:0004674,GO:0005515,GO:0005615,GO:0005737,GO:0005783,GO:0005794,GO:0006468,GO:0009617,GO:0016773,GO:0031214,GO:0043539,GO:0044691,GO:0055074,GO:0070062,GO:0070166,GO:0071902" "positive regulation of protein phosphorylation|protein serine/threonine kinase activity|protein binding|extracellular space|cytoplasm|endoplasmic reticulum|Golgi apparatus|protein phosphorylation|response to bacterium|phosphotransferase activity, alcohol group as acceptor|biomineral tissue development|protein serine/threonine kinase activator activity|tooth eruption|calcium ion homeostasis|extracellular exosome|enamel mineralization|positive regulation of protein serine/threonine kinase activity" FAM20B 1904.825824 1950.77603 1858.875619 0.952890332 -0.069617911 0.770447684 1 16.84617012 15.78393491 9917 FAM20B glycosaminoglycan xylosylkinase "GO:0000139,GO:0005515,GO:0005524,GO:0005654,GO:0005794,GO:0006468,GO:0016021,GO:0016301,GO:0016773,GO:0030166,GO:0046872" "Golgi membrane|protein binding|ATP binding|nucleoplasm|Golgi apparatus|protein phosphorylation|integral component of membrane|kinase activity|phosphotransferase activity, alcohol group as acceptor|proteoglycan biosynthetic process|metal ion binding" FAM20C 9254.743527 8018.469794 10491.01726 1.308356523 0.387755724 0.120608104 1 54.56911446 70.20114388 56975 FAM20C golgi associated secretory pathway kinase "GO:0004674,GO:0005515,GO:0005524,GO:0005615,GO:0005788,GO:0005794,GO:0006468,GO:0016773,GO:0030145,GO:0031214,GO:0043687,GO:0044267,GO:0046034,GO:0070062,GO:0070166,GO:0071895,GO:0106310,GO:0106311" "protein serine/threonine kinase activity|protein binding|ATP binding|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|protein phosphorylation|phosphotransferase activity, alcohol group as acceptor|manganese ion binding|biomineral tissue development|post-translational protein modification|cellular protein metabolic process|ATP metabolic process|extracellular exosome|enamel mineralization|odontoblast differentiation|protein serine kinase activity|protein threonine kinase activity" FAM210A 713.5005112 689.7944042 737.2066182 1.068733834 0.095902597 0.711347931 1 6.482313711 6.811939497 125228 family with sequence similarity 210 member A "GO:0003674,GO:0005737,GO:0005739,GO:0008150,GO:0016021" molecular_function|cytoplasm|mitochondrion|biological_process|integral component of membrane FAM210B 1472.19989 1418.084122 1526.315658 1.076322366 0.10611024 0.658572633 1 25.33663986 26.81405909 116151 family with sequence similarity 210 member B "GO:0005515,GO:0005739,GO:0005741,GO:0016021,GO:0031224,GO:0043249,GO:0045648,GO:0071392" protein binding|mitochondrion|mitochondrial outer membrane|integral component of membrane|intrinsic component of membrane|erythrocyte maturation|positive regulation of erythrocyte differentiation|cellular response to estradiol stimulus FAM214A 212.0424856 229.9314681 194.1535031 0.844397266 -0.244006187 0.497552837 1 2.19321177 1.820952282 56204 family with sequence similarity 214 member A GO:0005515 protein binding FAM214B 1280.986418 1078.909196 1483.06364 1.37459542 0.459007058 0.056858246 1 16.0120692 21.6418075 80256 family with sequence similarity 214 member B "GO:0005515,GO:0005634" protein binding|nucleus FAM216A 324.3090341 300.6796121 347.9384561 1.157173423 0.210605095 0.497072464 1 10.12411247 11.51931331 29902 family with sequence similarity 216 member A FAM217B 326.2804214 377.6702394 274.8906034 0.72785879 -0.458269511 0.134848876 1 3.791491074 2.713490763 63939 family with sequence similarity 217 member B "GO:0005515,GO:0005654,GO:0005829" protein binding|nucleoplasm|cytosol FAM219A 1356.332136 1240.173348 1472.490925 1.187326697 0.247716952 0.302283846 1 18.15796221 21.19866537 203259 family with sequence similarity 219 member A FAM219B 658.9322738 745.9767539 571.8877938 0.766629511 -0.38339856 0.138108024 1 11.79946897 8.894451557 57184 family with sequence similarity 219 member B GO:0005515 protein binding FAM220A 399.9573071 406.8018281 393.112786 0.966349605 -0.049382874 0.872826329 1 9.779399052 9.292180133 84792 family with sequence similarity 220 member A "GO:0000122,GO:0005515,GO:0005634,GO:0006470,GO:0097677" negative regulation of transcription by RNA polymerase II|protein binding|nucleus|protein dephosphorylation|STAT family protein binding FAM221A 113.0937263 105.0818021 121.1056505 1.15248928 0.204753331 0.66061481 1 2.387408535 2.70542074 340277 family with sequence similarity 221 member A GO:0005515 protein binding FAM222B 453.3109091 482.7520415 423.8697766 0.878027932 -0.187661259 0.505573539 1 3.363831988 2.904114977 55731 family with sequence similarity 222 member B "GO:0005515,GO:0005654" protein binding|nucleoplasm FAM227A 95.47085697 109.2434577 81.69825626 0.74785491 -0.419169691 0.382751755 1 0.543195989 0.399434049 646851 family with sequence similarity 227 member A FAM227B 14.85325794 11.44455271 18.26196316 1.595690424 0.674180785 0.513436683 1 0.076933461 0.120707731 196951 family with sequence similarity 227 member B FAM228A 6.445658531 5.202069413 7.689247648 1.478113235 0.563756795 0.78195947 1 0.152206625 0.221213914 653140 family with sequence similarity 228 member A GO:0005515 protein binding FAM228B 53.7649829 48.89945248 58.63051332 1.199001427 0.261833376 0.675000568 1 1.558014272 1.836801859 375190 family with sequence similarity 228 member B FAM229A 33.82854244 30.1720026 37.48508228 1.242379659 0.313106114 0.680168972 1 2.303611337 2.814068844 100128071 family with sequence similarity 229 member A FAM229B 164.5596149 194.5573961 134.5618338 0.691630524 -0.531926553 0.174542931 1 15.90072074 10.81339683 619208 family with sequence similarity 229 member B GO:0005515 protein binding FAM234A 1053.137736 1115.323682 990.9517906 0.888488074 -0.170575683 0.487027476 1 14.12165481 12.33696615 83986 family with sequence similarity 234 member A "GO:0003674,GO:0008150,GO:0009986,GO:0016021,GO:0070062" molecular_function|biological_process|cell surface|integral component of membrane|extracellular exosome FAM234B 815.0905486 719.9664068 910.2146903 1.264246056 0.338277278 0.177992758 1 8.156078091 10.13874409 57613 family with sequence similarity 234 member B "GO:0005856,GO:0016021,GO:0150051" cytoskeleton|integral component of membrane|postsynaptic Golgi apparatus FAM241A 384.930442 428.6505196 341.2103644 0.796010616 -0.329140423 0.260700715 1 2.586645229 2.024542536 132720 family with sequence similarity 241 member A "GO:0005794,GO:0016021,GO:0043231" Golgi apparatus|integral component of membrane|intracellular membrane-bounded organelle FAM241B 48.60254245 39.53572754 57.66935736 1.458664376 0.544647972 0.376682131 1 1.036830032 1.487079283 219738 family with sequence similarity 241 member B "GO:0005515,GO:0016021,GO:0043231" protein binding|integral component of membrane|intracellular membrane-bounded organelle FAM24B 62.41035609 61.38441908 63.4362931 1.033426626 0.04743596 0.96371881 1 4.321864942 4.391592316 196792 family with sequence similarity 24 member B "GO:0005515,GO:0005576" protein binding|extracellular region FAM25A 12.41073908 10.40413883 14.41733934 1.385731158 0.470647391 0.70561241 1 1.555321477 2.119192116 643161 family with sequence similarity 25 member A FAM32A 1234.929576 1181.910171 1287.948981 1.089718164 0.123955056 0.609656703 1 37.34539583 40.01496445 26017 family with sequence similarity 32 member A "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006915,GO:0007049,GO:0008150" RNA binding|protein binding|nucleoplasm|nucleolus|apoptotic process|cell cycle|biological_process FAM3A 1063.755726 1002.958983 1124.552469 1.121234754 0.165088368 0.500959921 1 28.20130535 31.09116104 60343 FAM3 metabolism regulating signaling molecule A "GO:0003674,GO:0005575,GO:0005615,GO:0019732,GO:0045721,GO:0046890,GO:0061844,GO:1905035" molecular_function|cellular_component|extracellular space|antifungal humoral response|negative regulation of gluconeogenesis|regulation of lipid biosynthetic process|antimicrobial humoral immune response mediated by antimicrobial peptide|negative regulation of antifungal innate immune response FAM3C 1692.597712 1286.991973 2098.203452 1.630315881 0.70515152 0.003082573 0.360292185 24.69773326 39.59132473 10447 FAM3 metabolism regulating signaling molecule C "GO:0002576,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005794,GO:0007165,GO:0007275,GO:0008150,GO:0031089,GO:0045721,GO:0070062" platelet degranulation|cytokine activity|protein binding|extracellular region|extracellular space|Golgi apparatus|signal transduction|multicellular organism development|biological_process|platelet dense granule lumen|negative regulation of gluconeogenesis|extracellular exosome FAM43A 145.8170738 194.5573961 97.07675156 0.498962021 -1.002998087 0.014649963 0.710419281 3.291020807 1.614616168 131583 family with sequence similarity 43 member A GO:0005515 protein binding FAM43B 17.45429264 16.64662212 18.26196316 1.097037166 0.133612404 0.951103304 1 0.362908345 0.391461877 163933 family with sequence similarity 43 member B FAM47E 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.02737918 0.07461061 100129583 family with sequence similarity 47 member E "GO:0003674,GO:0005737,GO:0008150" molecular_function|cytoplasm|biological_process FAM50A 3377.64653 3120.201234 3635.091826 1.165018392 0.220352731 0.352992059 1 124.5470495 142.671558 9130 family with sequence similarity 50 member A "GO:0003723,GO:0005634,GO:0005654,GO:0006325,GO:0007283" RNA binding|nucleus|nucleoplasm|chromatin organization|spermatogenesis FAM50B 14.01098887 14.56579436 13.45618338 0.923820772 -0.11431511 0.989463584 1 0.444962607 0.404187071 26240 family with sequence similarity 50 member B "GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0030496,GO:0045171" protein binding|nucleus|nucleoplasm|chromatin organization|midbody|intercellular bridge FAM53A 48.7610583 43.69738307 53.82473354 1.231761029 0.300722389 0.639838995 1 0.395329551 0.47880306 152877 family with sequence similarity 53 member A "GO:0005634,GO:0006606" nucleus|protein import into nucleus FAM53B 191.1499196 198.7190516 183.5807876 0.923820772 -0.11431511 0.76869157 1 1.841512511 1.672759771 9679 family with sequence similarity 53 member B "GO:0005634,GO:0006606,GO:0016055,GO:0060828,GO:0090263" nucleus|protein import into nucleus|Wnt signaling pathway|regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway FAM53C 1471.78728 1646.975176 1296.599385 0.787261037 -0.345086017 0.148506188 1 19.86351144 15.37609173 51307 family with sequence similarity 53 member C "GO:0005515,GO:0005634,GO:0006606" protein binding|nucleus|protein import into nucleus FAM71D 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.058943712 0 161142 family with sequence similarity 71 member D FAM71F2 6.643803347 10.40413883 2.883467868 0.277146232 -1.851280704 0.208965374 1 0.142554497 0.038847321 346653 family with sequence similarity 71 member F2 FAM72A 261.9578142 291.3158871 232.5997414 0.798445096 -0.32473489 0.326376233 1 3.202924079 2.514565083 729533 family with sequence similarity 72 member A "GO:0005515,GO:0005739,GO:0005829,GO:0016020,GO:0043231" protein binding|mitochondrion|cytosol|membrane|intracellular membrane-bounded organelle FAM72B 454.7973024 471.3074888 438.2871159 0.92993879 -0.104792336 0.713526413 1 10.59511982 9.687939426 653820 family with sequence similarity 72 member B "GO:0005829,GO:0016020,GO:0043231" cytosol|membrane|intracellular membrane-bounded organelle FAM72C 84.86857333 83.23311061 86.50403604 1.039298368 0.055609892 0.936067039 1 1.523318977 1.556690505 554282 family with sequence similarity 72 member C "GO:0005829,GO:0016020,GO:0043231" cytosol|membrane|intracellular membrane-bounded organelle FAM72D 209.1193888 228.8910542 189.3477233 0.827239509 -0.273623004 0.447994553 1 2.792751458 2.271615033 728833 family with sequence similarity 72 member D "GO:0005515,GO:0005829,GO:0016020,GO:0043231" protein binding|cytosol|membrane|intracellular membrane-bounded organelle FAM76A 156.5287979 147.7387713 165.3188244 1.118994174 0.162202525 0.695834161 1 1.526533726 1.679598228 199870 family with sequence similarity 76 member A GO:0005654 nucleoplasm FAM76B 447.4005487 441.1354862 453.6656112 1.028404255 0.040407485 0.893610384 1 5.757542218 5.821999646 143684 family with sequence similarity 76 member B "GO:0005515,GO:0016607" protein binding|nuclear speck FAM78A 50.44056602 49.93986637 50.94126567 1.020052102 0.028642844 1 1 0.528809302 0.530386693 286336 family with sequence similarity 78 member A GO:0005515 protein binding FAM81A 29.41905229 40.57614142 18.26196316 0.45006653 -1.151789815 0.116605908 1 0.499072158 0.220857035 145773 family with sequence similarity 81 member A GO:0005515 protein binding FAM83A 1822.363827 1262.02204 2382.705615 1.888006342 0.916863611 0.000122161 0.04393817 14.22124087 26.40049803 84985 family with sequence similarity 83 member A "GO:0005515,GO:0005737,GO:0007165,GO:0007173,GO:0008283,GO:0019901,GO:0036312,GO:0042802" protein binding|cytoplasm|signal transduction|epidermal growth factor receptor signaling pathway|cell population proliferation|protein kinase binding|phosphatidylinositol 3-kinase regulatory subunit binding|identical protein binding FAM83B 67.3696213 78.0310412 56.7082014 0.726739007 -0.460490751 0.398512387 1 0.812085268 0.580298278 222584 family with sequence similarity 83 member B "GO:0004630,GO:0005154,GO:0005515,GO:0005737,GO:0007165,GO:0007173,GO:0008283,GO:0016020,GO:0019901,GO:0036312,GO:0036313" phospholipase D activity|epidermal growth factor receptor binding|protein binding|cytoplasm|signal transduction|epidermal growth factor receptor signaling pathway|cell population proliferation|membrane|protein kinase binding|phosphatidylinositol 3-kinase regulatory subunit binding|phosphatidylinositol 3-kinase catalytic subunit binding FAM83D 2002.390757 2329.486683 1675.294831 0.719169096 -0.475597069 0.044556777 1 44.06962881 31.16316704 81610 family with sequence similarity 83 member D "GO:0001837,GO:0005515,GO:0005737,GO:0005819,GO:0005829,GO:0007165,GO:0008017,GO:0008283,GO:0015630,GO:0016477,GO:0019894,GO:0019901,GO:0032006,GO:0042176,GO:0045171,GO:0051301,GO:0051310,GO:0070372,GO:0072686,GO:0097431,GO:1902480,GO:1902808" epithelial to mesenchymal transition|protein binding|cytoplasm|spindle|cytosol|signal transduction|microtubule binding|cell population proliferation|microtubule cytoskeleton|cell migration|kinesin binding|protein kinase binding|regulation of TOR signaling|regulation of protein catabolic process|intercellular bridge|cell division|metaphase plate congression|regulation of ERK1 and ERK2 cascade|mitotic spindle|mitotic spindle pole|protein localization to mitotic spindle|positive regulation of cell cycle G1/S phase transition FAM83G 965.2523315 965.5040831 965.0005798 0.999478507 -0.000752551 1 1 9.634850111 9.468683517 644815 family with sequence similarity 83 member G "GO:0005515,GO:0005634,GO:0005829,GO:0007165,GO:0019901,GO:0030509" protein binding|nucleus|cytosol|signal transduction|protein kinase binding|BMP signaling pathway FAM83H 1125.903156 1120.525752 1131.28056 1.009598002 0.013780961 0.958841681 1 10.61796874 10.54049735 286077 family with sequence similarity 83 member H "GO:0005515,GO:0005737,GO:0007165,GO:0019901,GO:0030335,GO:0031214,GO:0044380,GO:0045095,GO:0045104,GO:1990254" protein binding|cytoplasm|signal transduction|protein kinase binding|positive regulation of cell migration|biomineral tissue development|protein localization to cytoskeleton|keratin filament|intermediate filament cytoskeleton organization|keratin filament binding FAM86B1 51.67912472 57.22276355 46.13548589 0.806243583 -0.310712323 0.617964739 1 0.71536044 0.567103554 85002 family with sequence similarity 86 member B1 "GO:0008168,GO:0032259" methyltransferase activity|methylation FAM86B2 27.66028665 32.25283036 23.06774294 0.715216081 -0.48354892 0.539168717 1 0.683587879 0.480731746 653333 family with sequence similarity 86 member B2 "GO:0005515,GO:0008150,GO:0008168,GO:0032259,GO:0032991" protein binding|biological_process|methyltransferase activity|methylation|protein-containing complex FAM89A 187.9248823 151.9004269 223.9493377 1.474316711 0.560046476 0.132753838 1 5.39364378 7.818874225 375061 family with sequence similarity 89 member A FAM89B 474.867721 455.7012806 494.0341614 1.08411844 0.11652238 0.678813266 1 19.28623299 20.55868437 23625 family with sequence similarity 89 member B "GO:0001222,GO:0005737,GO:0030010,GO:0030027,GO:0030335,GO:0030512,GO:0060392" transcription corepressor binding|cytoplasm|establishment of cell polarity|lamellipodium|positive regulation of cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of SMAD protein signal transduction FAM8A1 671.7053184 652.3395044 691.0711324 1.059373421 0.083211218 0.751458198 1 7.366517224 7.673304978 51439 family with sequence similarity 8 member A1 "GO:0000839,GO:0005515,GO:0016021" Hrd1p ubiquitin ligase ERAD-L complex|protein binding|integral component of membrane FAM91A1 3013.988623 2972.462463 3055.514784 1.027940579 0.03975687 0.867922986 1 27.16815525 27.45992453 157769 family with sequence similarity 91 member A1 "GO:0005515,GO:0005802,GO:0006886,GO:0031410,GO:0099041" protein binding|trans-Golgi network|intracellular protein transport|cytoplasmic vesicle|vesicle tethering to Golgi FAM98A 1703.099388 1562.701652 1843.497124 1.179685912 0.238402798 0.315649616 1 30.31570884 35.16456903 25940 family with sequence similarity 98 member A "GO:0003723,GO:0005515,GO:0006479,GO:0008276,GO:0008284,GO:0010628,GO:0032418,GO:0072669,GO:1900029" RNA binding|protein binding|protein methylation|protein methyltransferase activity|positive regulation of cell population proliferation|positive regulation of gene expression|lysosome localization|tRNA-splicing ligase complex|positive regulation of ruffle assembly FAM98B 794.648378 763.6637899 825.6329662 1.081147197 0.112562958 0.658055535 1 9.287906315 9.873561408 283742 family with sequence similarity 98 member B "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006388,GO:0006479,GO:0008276,GO:0008284,GO:0010628,GO:0042802,GO:0043231,GO:0072669" "RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|tRNA splicing, via endonucleolytic cleavage and ligation|protein methylation|protein methyltransferase activity|positive regulation of cell population proliferation|positive regulation of gene expression|identical protein binding|intracellular membrane-bounded organelle|tRNA-splicing ligase complex" FAM98C 177.4955914 193.5169822 161.4742006 0.834418762 -0.261156498 0.498108851 1 8.03082867 6.588940713 147965 family with sequence similarity 98 member C "GO:0005515,GO:0072669" protein binding|tRNA-splicing ligase complex FAN1 483.9043534 491.0753526 476.7333542 0.970794709 -0.042761849 0.884030945 1 4.295654648 4.100416176 22909 FANCD2 and FANCI associated nuclease 1 "GO:0000287,GO:0000724,GO:0004528,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006289,GO:0008409,GO:0017108,GO:0033683,GO:0036297,GO:0045171,GO:0070336,GO:0140036" "magnesium ion binding|double-strand break repair via homologous recombination|phosphodiesterase I activity|protein binding|nucleus|nucleoplasm|cytosol|DNA repair|nucleotide-excision repair|5'-3' exonuclease activity|5'-flap endonuclease activity|nucleotide-excision repair, DNA incision|interstrand cross-link repair|intercellular bridge|flap-structured DNA binding|ubiquitin-dependent protein binding" hsa03460 Fanconi anemia pathway FANCA 1450.722336 1447.215711 1454.228961 1.00484603 0.006974458 0.979971871 1 12.49356885 12.34403698 2175 FA complementation group A "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006281,GO:0007140,GO:0008584,GO:0008585,GO:0036297,GO:0042127,GO:0043240,GO:0045589,GO:0050727,GO:0051090,GO:0065003,GO:2000348" protein binding|nucleus|nucleoplasm|cytoplasm|DNA repair|male meiotic nuclear division|male gonad development|female gonad development|interstrand cross-link repair|regulation of cell population proliferation|Fanconi anaemia nuclear complex|regulation of regulatory T cell differentiation|regulation of inflammatory response|regulation of DNA-binding transcription factor activity|protein-containing complex assembly|regulation of CD40 signaling pathway hsa03460 Fanconi anemia pathway FANCB 448.7479335 476.5095583 420.9863087 0.883479253 -0.178731838 0.527476592 1 3.307809487 2.873478966 2187 FA complementation group B "GO:0005515,GO:0005654,GO:0036297,GO:0043240,GO:1905168,GO:1990414,GO:2000042" protein binding|nucleoplasm|interstrand cross-link repair|Fanconi anaemia nuclear complex|positive regulation of double-strand break repair via homologous recombination|replication-born double-strand break repair via sister chromatid exchange|negative regulation of double-strand break repair via homologous recombination hsa03460 Fanconi anemia pathway FANCC 371.7768135 373.5085839 370.0450431 0.990727011 -0.013440508 0.973852631 1 2.129871422 2.074811129 2176 FA complementation group C "GO:0002262,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006281,GO:0006289,GO:0007281,GO:0019430,GO:0034599,GO:0036297,GO:0043240,GO:0048854,GO:0065003,GO:0097150" myeloid cell homeostasis|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA repair|nucleotide-excision repair|germ cell development|removal of superoxide radicals|cellular response to oxidative stress|interstrand cross-link repair|Fanconi anaemia nuclear complex|brain morphogenesis|protein-containing complex assembly|neuronal stem cell population maintenance hsa03460 Fanconi anemia pathway FANCD2 1535.535575 1667.783454 1403.287696 0.841408813 -0.249121166 0.296168358 1 15.01713138 12.42410792 2177 FA complementation group D2 "GO:0000793,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0007129,GO:0007276,GO:0010332,GO:0016604,GO:0031573,GO:0034599,GO:0036297,GO:0045589,GO:0048854,GO:0050727,GO:0051090,GO:0070182,GO:0097150,GO:1990918,GO:2000348" condensed chromosome|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|homologous chromosome pairing at meiosis|gamete generation|response to gamma radiation|nuclear body|intra-S DNA damage checkpoint|cellular response to oxidative stress|interstrand cross-link repair|regulation of regulatory T cell differentiation|brain morphogenesis|regulation of inflammatory response|regulation of DNA-binding transcription factor activity|DNA polymerase binding|neuronal stem cell population maintenance|double-strand break repair involved in meiotic recombination|regulation of CD40 signaling pathway hsa03460 Fanconi anemia pathway other FANCE 280.6311583 264.2651262 296.9971904 1.123860703 0.168463231 0.607779129 1 5.169847539 5.712962852 2178 FA complementation group E "GO:0003674,GO:0005634,GO:0005654,GO:0036297,GO:0043240" molecular_function|nucleus|nucleoplasm|interstrand cross-link repair|Fanconi anaemia nuclear complex hsa03460 Fanconi anemia pathway FANCF 498.7179824 501.4794914 495.9564733 0.988986552 -0.015977191 0.961471348 1 8.132190452 7.908044527 2188 FA complementation group F "GO:0003674,GO:0005515,GO:0005654,GO:0006974,GO:0008150,GO:0036297,GO:0043240" molecular_function|protein binding|nucleoplasm|cellular response to DNA damage stimulus|biological_process|interstrand cross-link repair|Fanconi anaemia nuclear complex hsa03460 Fanconi anemia pathway FANCG 1730.456505 1751.016564 1709.896446 0.976516431 -0.034283776 0.887504903 1 36.56046002 35.10446715 2189 FA complementation group G "GO:0001541,GO:0003684,GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0005829,GO:0005886,GO:0006281,GO:0006974,GO:0007005,GO:0007286,GO:0009314,GO:0036297,GO:0043240" ovarian follicle development|damaged DNA binding|protein binding|nucleoplasm|nucleolus|mitochondrion|cytosol|plasma membrane|DNA repair|cellular response to DNA damage stimulus|mitochondrion organization|spermatid development|response to radiation|interstrand cross-link repair|Fanconi anaemia nuclear complex hsa03460 Fanconi anemia pathway FANCI 3252.522034 3254.414625 3250.629443 0.998836909 -0.001678963 0.995829537 1 36.38846159 35.73793508 55215 FA complementation group I "GO:0003677,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0007049,GO:0016020,GO:0031398,GO:0036297,GO:0070182" DNA binding|protein binding|nucleoplasm|cytoplasm|cytosol|cell cycle|membrane|positive regulation of protein ubiquitination|interstrand cross-link repair|DNA polymerase binding hsa03460 Fanconi anemia pathway FANCL 559.2412395 475.4691444 643.0133346 1.352376578 0.435496936 0.102461774 1 11.54980171 15.35830711 55120 FA complementation group L "GO:0004842,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0006281,GO:0006513,GO:0006974,GO:0007276,GO:0016604,GO:0031625,GO:0036297,GO:0042127,GO:0043231,GO:0043240,GO:0046872,GO:0061630" ubiquitin-protein transferase activity|protein binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|DNA repair|protein monoubiquitination|cellular response to DNA damage stimulus|gamete generation|nuclear body|ubiquitin protein ligase binding|interstrand cross-link repair|regulation of cell population proliferation|intracellular membrane-bounded organelle|Fanconi anaemia nuclear complex|metal ion binding|ubiquitin protein ligase activity "hsa03460,hsa04120" Fanconi anemia pathway|Ubiquitin mediated proteolysis FANCM 334.0589878 354.781134 313.3368417 0.883183494 -0.179214885 0.560876495 1 2.743662811 2.382609446 57697 FA complementation group M "GO:0000400,GO:0000712,GO:0003682,GO:0003724,GO:0004518,GO:0005515,GO:0005524,GO:0005654,GO:0009378,GO:0031297,GO:0032508,GO:0036297,GO:0043138,GO:0043240,GO:0045003,GO:0071821,GO:0071932,GO:0090305,GO:1902527" four-way junction DNA binding|resolution of meiotic recombination intermediates|chromatin binding|RNA helicase activity|nuclease activity|protein binding|ATP binding|nucleoplasm|four-way junction helicase activity|replication fork processing|DNA duplex unwinding|interstrand cross-link repair|3'-5' DNA helicase activity|Fanconi anaemia nuclear complex|double-strand break repair via synthesis-dependent strand annealing|FANCM-MHF complex|replication fork reversal|nucleic acid phosphodiester bond hydrolysis|positive regulation of protein monoubiquitination hsa03460 Fanconi anemia pathway FANK1 43.51432951 44.73779695 42.29086206 0.945304976 -0.081148246 0.936132233 1 0.647389913 0.601740234 92565 fibronectin type III and ankyrin repeat domains 1 "GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005929,GO:0036064,GO:0042981,GO:0043065,GO:0043066,GO:0045893,GO:0051091,GO:0097546" "chromatin|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cilium|ciliary basal body|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of transcription, DNA-templated|positive regulation of DNA-binding transcription factor activity|ciliary base" FAR1 2480.708656 2472.023385 2489.393926 1.007026851 0.010102152 0.967792351 1 25.04315579 24.79712233 84188 fatty acyl-CoA reductase 1 "GO:0005515,GO:0005777,GO:0005778,GO:0005779,GO:0005782,GO:0008611,GO:0010025,GO:0016491,GO:0035336,GO:0043231,GO:0046474,GO:0055114,GO:0080019,GO:0102965" protein binding|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|peroxisomal matrix|ether lipid biosynthetic process|wax biosynthetic process|oxidoreductase activity|long-chain fatty-acyl-CoA metabolic process|intracellular membrane-bounded organelle|glycerophospholipid biosynthetic process|oxidation-reduction process|fatty-acyl-CoA reductase (alcohol-forming) activity|alcohol-forming fatty acyl-CoA reductase activity hsa04146 Peroxisome FAR2 288.7016043 312.1241648 265.2790439 0.84991511 -0.234609344 0.466659873 1 2.898467551 2.422228845 55711 fatty acyl-CoA reductase 2 "GO:0005777,GO:0005779,GO:0005782,GO:0006629,GO:0010025,GO:0016491,GO:0035336,GO:0043231,GO:0055114,GO:0080019,GO:0102965" peroxisome|integral component of peroxisomal membrane|peroxisomal matrix|lipid metabolic process|wax biosynthetic process|oxidoreductase activity|long-chain fatty-acyl-CoA metabolic process|intracellular membrane-bounded organelle|oxidation-reduction process|fatty-acyl-CoA reductase (alcohol-forming) activity|alcohol-forming fatty acyl-CoA reductase activity hsa04146 Peroxisome FARP1 1535.873957 1424.326605 1647.421309 1.156631704 0.209929553 0.379000361 1 10.22376505 11.62725324 10160 "FERM, ARH/RhoGEF and pleckstrin domain protein 1" "GO:0005085,GO:0005515,GO:0005829,GO:0005856,GO:0007416,GO:0008092,GO:0010923,GO:0030175,GO:0030425,GO:0031234,GO:0043197,GO:0048813" guanyl-nucleotide exchange factor activity|protein binding|cytosol|cytoskeleton|synapse assembly|cytoskeletal protein binding|negative regulation of phosphatase activity|filopodium|dendrite|extrinsic component of cytoplasmic side of plasma membrane|dendritic spine|dendrite morphogenesis FARP2 326.7509385 402.6401726 250.8617045 0.623041916 -0.682598869 0.025906197 0.86539048 3.742278995 2.292580562 9855 "FERM, ARH/RhoGEF and pleckstrin domain protein 2" "GO:0005085,GO:0005737,GO:0005829,GO:0005856,GO:0007155,GO:0008092,GO:0016322,GO:0016601,GO:0022405,GO:0030316,GO:0031532,GO:0033623,GO:0050790,GO:0071526,GO:0071800" guanyl-nucleotide exchange factor activity|cytoplasm|cytosol|cytoskeleton|cell adhesion|cytoskeletal protein binding|neuron remodeling|Rac protein signal transduction|hair cycle process|osteoclast differentiation|actin cytoskeleton reorganization|regulation of integrin activation|regulation of catalytic activity|semaphorin-plexin signaling pathway|podosome assembly "hsa04015,hsa04520" Rap1 signaling pathway|Adherens junction FARS2 212.2506912 210.1636043 214.3377782 1.019861545 0.028373307 0.950826511 1 1.692732463 1.697464569 10667 "phenylalanyl-tRNA synthetase 2, mitochondrial" "GO:0000049,GO:0004826,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005759,GO:0006418,GO:0006432,GO:0008033" tRNA binding|phenylalanine-tRNA ligase activity|protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial matrix|tRNA aminoacylation for protein translation|phenylalanyl-tRNA aminoacylation|tRNA processing hsa00970 Aminoacyl-tRNA biosynthesis FARSA 1130.936649 1151.738168 1110.135129 0.963878041 -0.05307748 0.830512246 1 33.94044684 32.16701937 2193 phenylalanyl-tRNA synthetase subunit alpha "GO:0000049,GO:0003723,GO:0004826,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006418,GO:0006432,GO:0009328,GO:0016020,GO:0051290" tRNA binding|RNA binding|phenylalanine-tRNA ligase activity|protein binding|ATP binding|cytoplasm|cytosol|tRNA aminoacylation for protein translation|phenylalanyl-tRNA aminoacylation|phenylalanine-tRNA ligase complex|membrane|protein heterotetramerization hsa00970 Aminoacyl-tRNA biosynthesis FARSB 2019.624825 1898.755336 2140.494314 1.127314443 0.172889984 0.465483142 1 11.02525106 12.22094354 10056 phenylalanyl-tRNA synthetase subunit beta "GO:0000287,GO:0003723,GO:0004826,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006412,GO:0006418,GO:0006432,GO:0009328,GO:0016020,GO:0051290" magnesium ion binding|RNA binding|phenylalanine-tRNA ligase activity|protein binding|ATP binding|cytoplasm|cytosol|translation|tRNA aminoacylation for protein translation|phenylalanyl-tRNA aminoacylation|phenylalanine-tRNA ligase complex|membrane|protein heterotetramerization hsa00970 Aminoacyl-tRNA biosynthesis FAS 1159.220938 1225.607554 1092.834322 0.891667417 -0.165422395 0.496829142 1 8.165845515 7.159377051 355 Fas cell surface death receptor "GO:0001934,GO:0005031,GO:0005515,GO:0005516,GO:0005829,GO:0005886,GO:0006915,GO:0006919,GO:0006924,GO:0006955,GO:0007165,GO:0009897,GO:0009986,GO:0016021,GO:0016604,GO:0019900,GO:0031264,GO:0031265,GO:0032872,GO:0033209,GO:0034198,GO:0036337,GO:0038023,GO:0042802,GO:0042981,GO:0043065,GO:0043066,GO:0045121,GO:0065003,GO:0070062,GO:0071260,GO:0071455,GO:0097049,GO:0097190,GO:0097191,GO:0097192,GO:0097527,GO:1902041,GO:1902042,GO:2001235,GO:2001269" positive regulation of protein phosphorylation|tumor necrosis factor-activated receptor activity|protein binding|calmodulin binding|cytosol|plasma membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|activation-induced cell death of T cells|immune response|signal transduction|external side of plasma membrane|cell surface|integral component of membrane|nuclear body|kinase binding|death-inducing signaling complex|CD95 death-inducing signaling complex|regulation of stress-activated MAPK cascade|tumor necrosis factor-mediated signaling pathway|cellular response to amino acid starvation|Fas signaling pathway|signaling receptor activity|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|membrane raft|protein-containing complex assembly|extracellular exosome|cellular response to mechanical stimulus|cellular response to hyperoxia|motor neuron apoptotic process|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|necroptotic signaling pathway|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of apoptotic signaling pathway|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway "hsa01524,hsa04010,hsa04060,hsa04115,hsa04210,hsa04217,hsa04650,hsa04668,hsa04932,hsa04940,hsa05010,hsa05022,hsa05130,hsa05142,hsa05143,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05205,hsa05320,hsa05330,hsa05332" Platinum drug resistance|MAPK signaling pathway|Cytokine-cytokine receptor interaction|p53 signaling pathway|Apoptosis|Necroptosis|Natural killer cell mediated cytotoxicity|TNF signaling pathway|Non-alcoholic fatty liver disease|Type I diabetes mellitus|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Chagas disease|African trypanosomiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease FASN 2407.624976 2660.338298 2154.911653 0.810014146 -0.303980992 0.198436075 1 16.77426341 13.36002406 2194 fatty acid synthase "GO:0001649,GO:0002068,GO:0003723,GO:0004313,GO:0004314,GO:0004315,GO:0004316,GO:0004317,GO:0004320,GO:0005515,GO:0005794,GO:0005829,GO:0005886,GO:0006084,GO:0006631,GO:0006633,GO:0008611,GO:0008659,GO:0008693,GO:0016020,GO:0016295,GO:0016296,GO:0030223,GO:0030224,GO:0030879,GO:0031177,GO:0031325,GO:0042470,GO:0042587,GO:0042802,GO:0045296,GO:0045540,GO:0046949,GO:0047117,GO:0047451,GO:0055114,GO:0070062,GO:0071353,GO:0090557,GO:0102131,GO:0102132" "osteoblast differentiation|glandular epithelial cell development|RNA binding|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|protein binding|Golgi apparatus|cytosol|plasma membrane|acetyl-CoA metabolic process|fatty acid metabolic process|fatty acid biosynthetic process|ether lipid biosynthetic process|(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity|3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity|membrane|myristoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|neutrophil differentiation|monocyte differentiation|mammary gland development|phosphopantetheine binding|positive regulation of cellular metabolic process|melanosome|glycogen granule|identical protein binding|cadherin binding|regulation of cholesterol biosynthetic process|fatty-acyl-CoA biosynthetic process|enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity|3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity|oxidation-reduction process|extracellular exosome|cellular response to interleukin-4|establishment of endothelial intestinal barrier|3-oxo-glutaryl-[acp] methyl ester reductase activity|3-oxo-pimeloyl-[acp] methyl ester reductase activity" "hsa00061,hsa04152,hsa04910" Fatty acid biosynthesis|AMPK signaling pathway|Insulin signaling pathway FASTK 861.8689299 913.483389 810.2544709 0.886994203 -0.173003419 0.489602227 1 21.27932325 18.55879489 10922 Fas activated serine/threonine kinase "GO:0003723,GO:0004674,GO:0005515,GO:0005524,GO:0005759,GO:0006468,GO:0033867,GO:0043484,GO:0044528,GO:0097190" RNA binding|protein serine/threonine kinase activity|protein binding|ATP binding|mitochondrial matrix|protein phosphorylation|Fas-activated serine/threonine kinase activity|regulation of RNA splicing|regulation of mitochondrial mRNA stability|apoptotic signaling pathway FASTKD1 590.0322142 589.9146715 590.149757 1.000398508 0.000574811 1 1 4.997247905 4.915583846 79675 FAST kinase domains 1 "GO:0000959,GO:0003723,GO:0005515,GO:0005739,GO:0044528" mitochondrial RNA metabolic process|RNA binding|protein binding|mitochondrion|regulation of mitochondrial mRNA stability FASTKD2 840.4416801 817.7653118 863.1180485 1.055459355 0.077871023 0.759368912 1 6.593538556 6.842758964 22868 FAST kinase domains 2 "GO:0003723,GO:0005515,GO:0005739,GO:0005743,GO:0019843,GO:0035770,GO:0042645,GO:0044528,GO:0070131,GO:0140208,GO:1902775" RNA binding|protein binding|mitochondrion|mitochondrial inner membrane|rRNA binding|ribonucleoprotein granule|mitochondrial nucleoid|regulation of mitochondrial mRNA stability|positive regulation of mitochondrial translation|apoptotic process in response to mitochondrial fragmentation|mitochondrial large ribosomal subunit assembly FASTKD3 166.6108746 172.7087045 160.5130447 0.929385957 -0.105650249 0.799592781 1 3.791503963 3.464805012 79072 FAST kinase domains 3 "GO:0003723,GO:0005515,GO:0005654,GO:0005739,GO:0033617,GO:0044528,GO:0070131" RNA binding|protein binding|nucleoplasm|mitochondrion|mitochondrial cytochrome c oxidase assembly|regulation of mitochondrial mRNA stability|positive regulation of mitochondrial translation FASTKD5 483.458374 504.6007331 462.3160148 0.916201631 -0.126262963 0.651371198 1 9.4755854 8.536272873 60493 FAST kinase domains 5 "GO:0000963,GO:0003723,GO:0005515,GO:0005739,GO:0006397,GO:0019843,GO:0035770,GO:0042645,GO:0044528" mitochondrial RNA processing|RNA binding|protein binding|mitochondrion|mRNA processing|rRNA binding|ribonucleoprotein granule|mitochondrial nucleoid|regulation of mitochondrial mRNA stability FAT1 3716.709558 4275.060644 3158.358471 0.738786823 -0.43676996 0.066317709 1 15.04961275 10.9324033 2195 FAT atypical cadherin 1 "GO:0005509,GO:0005515,GO:0005634,GO:0005886,GO:0005887,GO:0005911,GO:0005925,GO:0007015,GO:0007155,GO:0007156,GO:0007163,GO:0007267,GO:0009653,GO:0016477,GO:0048471,GO:0070062,GO:0098609" calcium ion binding|protein binding|nucleus|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|actin filament organization|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|establishment or maintenance of cell polarity|cell-cell signaling|anatomical structure morphogenesis|cell migration|perinuclear region of cytoplasm|extracellular exosome|cell-cell adhesion FAT3 41.51779009 30.1720026 52.86357758 1.752073877 0.809063608 0.210911362 1 0.056285806 0.096966669 120114 FAT atypical cadherin 3 "GO:0005509,GO:0005886,GO:0007156,GO:0007275,GO:0016021,GO:0098609" calcium ion binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|multicellular organism development|integral component of membrane|cell-cell adhesion FAT4 833.3468669 833.37152 833.3222138 0.999940835 -8.54E-05 1 1 2.587590549 2.544140193 79633 FAT atypical cadherin 4 "GO:0001658,GO:0003007,GO:0005509,GO:0005515,GO:0005886,GO:0007009,GO:0007156,GO:0007157,GO:0007219,GO:0008543,GO:0016021,GO:0021987,GO:0022008,GO:0035329,GO:0043931,GO:0045177,GO:0048565,GO:0060122,GO:0070062,GO:0072137,GO:0072307,GO:0098609" branching involved in ureteric bud morphogenesis|heart morphogenesis|calcium ion binding|protein binding|plasma membrane|plasma membrane organization|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|Notch signaling pathway|fibroblast growth factor receptor signaling pathway|integral component of membrane|cerebral cortex development|neurogenesis|hippo signaling|ossification involved in bone maturation|apical part of cell|digestive tract development|inner ear receptor cell stereocilium organization|extracellular exosome|condensed mesenchymal cell proliferation|regulation of metanephric nephron tubule epithelial cell differentiation|cell-cell adhesion hsa04392 Hippo signaling pathway - multiple species FAU 4090.027984 3704.913836 4475.142131 1.207893713 0.272493513 0.252922548 1 390.759767 464.0980477 2197 FAU ubiquitin like and ribosomal protein S30 fusion "GO:0003723,GO:0005575,GO:0008150" RNA binding|cellular_component|biological_process "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 FAXC 96.67984754 90.51600779 102.8436873 1.136193363 0.184208381 0.713189738 1 0.409795807 0.457815969 84553 "failed axon connections homolog, metaxin like GST domain containing" "GO:0005737,GO:0016021" cytoplasm|integral component of membrane FBF1 348.0995448 395.3572754 300.8418142 0.760936583 -0.394151871 0.190160887 1 4.509401828 3.373949508 85302 Fas binding factor 1 "GO:0000922,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0036064,GO:0043296,GO:0043297,GO:0045095,GO:0060271,GO:0090162,GO:0097539,GO:0097711" spindle pole|protein binding|centrosome|centriole|cytosol|ciliary basal body|apical junction complex|apical junction assembly|keratin filament|cilium assembly|establishment of epithelial cell polarity|ciliary transition fiber|ciliary basal body-plasma membrane docking FBH1 1253.146265 1294.27487 1212.017661 0.936445332 -0.09473332 0.696807084 1 12.98610097 11.95727955 84893 F-box DNA helicase 1 "GO:0000724,GO:0000725,GO:0000737,GO:0000785,GO:0001934,GO:0003678,GO:0003690,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0006974,GO:0008219,GO:0015616,GO:0016567,GO:0019005,GO:0031297,GO:0032508,GO:0035562,GO:0043138,GO:0048478,GO:0072429,GO:1902231,GO:2000042" "double-strand break repair via homologous recombination|recombinational repair|DNA catabolic process, endonucleolytic|chromatin|positive regulation of protein phosphorylation|DNA helicase activity|double-stranded DNA binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|cellular response to DNA damage stimulus|cell death|DNA translocase activity|protein ubiquitination|SCF ubiquitin ligase complex|replication fork processing|DNA duplex unwinding|negative regulation of chromatin binding|3'-5' DNA helicase activity|replication fork protection|response to intra-S DNA damage checkpoint signaling|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of double-strand break repair via homologous recombination" FBL 2385.986333 2294.112611 2477.860055 1.080095215 0.111158498 0.639072209 1 110.1012353 116.9298553 2091 fibrillarin "GO:0000494,GO:0001094,GO:0001649,GO:0001650,GO:0001651,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0006364,GO:0008649,GO:0015030,GO:0016020,GO:0031167,GO:0031428,GO:0032040,GO:0048254,GO:0051117,GO:0070062,GO:1990258,GO:1990259" box C/D RNA 3'-end processing|TFIID-class transcription factor complex binding|osteoblast differentiation|fibrillar center|dense fibrillar component|RNA binding|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|rRNA processing|rRNA methyltransferase activity|Cajal body|membrane|rRNA methylation|box C/D RNP complex|small-subunit processome|snoRNA localization|ATPase binding|extracellular exosome|histone glutamine methylation|histone-glutamine methyltransferase activity hsa03008 Ribosome biogenesis in eukaryotes FBLIM1 2294.463281 2326.365442 2262.56112 0.972573388 -0.040120978 0.866914452 1 24.84070587 23.75513448 54751 filamin binding LIM protein 1 "GO:0001650,GO:0001725,GO:0005515,GO:0005737,GO:0005829,GO:0005925,GO:0008360,GO:0030054,GO:0031005,GO:0033623,GO:0034329,GO:0046872,GO:0071944,GO:0098609" fibrillar center|stress fiber|protein binding|cytoplasm|cytosol|focal adhesion|regulation of cell shape|cell junction|filamin binding|regulation of integrin activation|cell junction assembly|metal ion binding|cell periphery|cell-cell adhesion FBLN1 3005.968482 2799.753758 3212.183205 1.147309186 0.198254233 0.402560009 1 30.99952538 34.97089071 2192 fibulin 1 "GO:0001933,GO:0001968,GO:0005201,GO:0005509,GO:0005576,GO:0005615,GO:0007162,GO:0007229,GO:0008022,GO:0010952,GO:0016032,GO:0016504,GO:0030198,GO:0031012,GO:0042802,GO:0044877,GO:0062023,GO:0070051,GO:0070062,GO:0070373,GO:0071953,GO:0072378,GO:1900025,GO:2000146,GO:2000647" "negative regulation of protein phosphorylation|fibronectin binding|extracellular matrix structural constituent|calcium ion binding|extracellular region|extracellular space|negative regulation of cell adhesion|integrin-mediated signaling pathway|protein C-terminus binding|positive regulation of peptidase activity|viral process|peptidase activator activity|extracellular matrix organization|extracellular matrix|identical protein binding|protein-containing complex binding|collagen-containing extracellular matrix|fibrinogen binding|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|elastic fiber|blood coagulation, fibrin clot formation|negative regulation of substrate adhesion-dependent cell spreading|negative regulation of cell motility|negative regulation of stem cell proliferation" FBLN2 3.562190663 5.202069413 1.922311912 0.369528309 -1.436243205 0.543489417 1 0.059691439 0.021688571 2199 fibulin 2 "GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0010811,GO:0030023,GO:0030198,GO:0031012,GO:0050840,GO:0062023,GO:1903561" extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|positive regulation of cell-substrate adhesion|extracellular matrix constituent conferring elasticity|extracellular matrix organization|extracellular matrix|extracellular matrix binding|collagen-containing extracellular matrix|extracellular vesicle FBLN5 242.8787341 232.0122958 253.7451724 1.093671228 0.12917911 0.711587568 1 3.696140241 3.974718777 10516 fibulin 5 "GO:0005178,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0007160,GO:0008022,GO:0030023,GO:0030198,GO:0031012,GO:0034394,GO:0042803,GO:0046903,GO:0048251,GO:0062023,GO:0070062,GO:0071953,GO:2000121" integrin binding|calcium ion binding|protein binding|extracellular region|extracellular space|cell-matrix adhesion|protein C-terminus binding|extracellular matrix constituent conferring elasticity|extracellular matrix organization|extracellular matrix|protein localization to cell surface|protein homodimerization activity|secretion|elastic fiber assembly|collagen-containing extracellular matrix|extracellular exosome|elastic fiber|regulation of removal of superoxide radicals FBLN7 424.243487 464.0245917 384.4623824 0.828538809 -0.27135882 0.34177114 1 3.308502287 2.695351896 129804 fibulin 7 "GO:0005509,GO:0005615,GO:0005925,GO:0007155,GO:0008201,GO:0031012,GO:0043395,GO:0110151" calcium ion binding|extracellular space|focal adhesion|cell adhesion|heparin binding|extracellular matrix|heparan sulfate proteoglycan binding|positive regulation of biomineralization FBN1 1558.735453 1936.210236 1181.26067 0.610089053 -0.71290825 0.002844085 0.347257699 8.901023488 5.33954632 2200 fibrillin 1 "GO:0001501,GO:0001527,GO:0001656,GO:0005178,GO:0005179,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005604,GO:0005615,GO:0005788,GO:0007165,GO:0007507,GO:0008201,GO:0009653,GO:0030023,GO:0030198,GO:0031012,GO:0033627,GO:0035582,GO:0035583,GO:0042802,GO:0043010,GO:0043687,GO:0044267,GO:0044877,GO:0045671,GO:0048048,GO:0048050,GO:0062023,GO:0071560,GO:1990314,GO:2001205" skeletal system development|microfibril|metanephros development|integrin binding|hormone activity|extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|basement membrane|extracellular space|endoplasmic reticulum lumen|signal transduction|heart development|heparin binding|anatomical structure morphogenesis|extracellular matrix constituent conferring elasticity|extracellular matrix organization|extracellular matrix|cell adhesion mediated by integrin|sequestering of BMP in extracellular matrix|sequestering of TGFbeta in extracellular matrix|identical protein binding|camera-type eye development|post-translational protein modification|cellular protein metabolic process|protein-containing complex binding|negative regulation of osteoclast differentiation|embryonic eye morphogenesis|post-embryonic eye morphogenesis|collagen-containing extracellular matrix|cellular response to transforming growth factor beta stimulus|cellular response to insulin-like growth factor stimulus|negative regulation of osteoclast development hsa04350 TGF-beta signaling pathway FBRS 1726.364047 1769.744014 1682.984079 0.950975997 -0.072519167 0.761796422 1 18.17705647 16.99668753 64319 fibrosin FBRSL1 667.9003235 653.3799183 682.4207288 1.044447051 0.062739356 0.813058909 1 3.95617034 4.062866846 57666 fibrosin like 1 GO:0003723 RNA binding FBXL12 398.0897154 370.3873422 425.7920885 1.14958596 0.201114348 0.490771424 1 8.101185128 9.157168097 54850 F-box and leucine rich repeat protein 12 "GO:0000086,GO:0000209,GO:0005515,GO:0005634,GO:0005829,GO:0019005,GO:0031146,GO:0043153,GO:0043687,GO:0051726" G2/M transition of mitotic cell cycle|protein polyubiquitination|protein binding|nucleus|cytosol|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|entrainment of circadian clock by photoperiod|post-translational protein modification|regulation of cell cycle FBXL13 13.53041089 14.56579436 12.49502743 0.857833574 -0.221230314 0.898154764 1 0.119243699 0.100579543 222235 F-box and leucine rich repeat protein 13 "GO:0000209,GO:0005829,GO:0005856,GO:0019005,GO:0031146,GO:0031514,GO:0043687" protein polyubiquitination|cytosol|cytoskeleton|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|motile cilium|post-translational protein modification FBXL14 142.1114585 147.7387713 136.4841458 0.923820772 -0.11431511 0.796826706 1 0.870739558 0.790946623 144699 F-box and leucine rich repeat protein 14 "GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0006511,GO:0019005,GO:0031146,GO:0043687" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification FBXL15 600.0054649 586.7934298 613.2174999 1.045031299 0.063546151 0.814679905 1 14.71620624 15.12155111 79176 F-box and leucine rich repeat protein 15 "GO:0000086,GO:0000209,GO:0005515,GO:0005737,GO:0005829,GO:0009953,GO:0016567,GO:0019005,GO:0030282,GO:0030513,GO:0031146,GO:0043687" G2/M transition of mitotic cell cycle|protein polyubiquitination|protein binding|cytoplasm|cytosol|dorsal/ventral pattern formation|protein ubiquitination|SCF ubiquitin ligase complex|bone mineralization|positive regulation of BMP signaling pathway|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification FBXL17 540.4590694 474.4287305 606.4894082 1.278357252 0.354291071 0.187401305 1 1.338658633 1.682647952 64839 F-box and leucine rich repeat protein 17 "GO:0000086,GO:0000209,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006515,GO:0007399,GO:0008589,GO:0014033,GO:0016567,GO:0019005,GO:0031146,GO:0043153,GO:0043161,GO:0051726" G2/M transition of mitotic cell cycle|protein polyubiquitination|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein quality control for misfolded or incompletely synthesized proteins|nervous system development|regulation of smoothened signaling pathway|neural crest cell differentiation|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|entrainment of circadian clock by photoperiod|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of cell cycle FBXL18 746.5408904 787.5933092 705.4884717 0.895752241 -0.158828347 0.533772076 1 4.325211708 3.809486614 80028 F-box and leucine rich repeat protein 18 "GO:0000209,GO:0005829,GO:0019005,GO:0031146,GO:0043687" protein polyubiquitination|cytosol|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification FBXL19 794.2023986 777.1891703 811.2156269 1.043781434 0.061819646 0.810480503 1 8.318723949 8.537632546 54620 F-box and leucine rich repeat protein 19 "GO:0000209,GO:0003712,GO:0005515,GO:0005829,GO:0006357,GO:0006482,GO:0008270,GO:0016577,GO:0019005,GO:0032452,GO:0043161,GO:0043687,GO:0045322" protein polyubiquitination|transcription coregulator activity|protein binding|cytosol|regulation of transcription by RNA polymerase II|protein demethylation|zinc ion binding|histone demethylation|SCF ubiquitin ligase complex|histone demethylase activity|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|unmethylated CpG binding FBXL2 483.9395663 403.6805865 564.1985462 1.397636064 0.482988741 0.079499591 1 5.018330064 6.896432652 25827 F-box and leucine rich repeat protein 2 "GO:0005515,GO:0005516,GO:0005737,GO:0006464,GO:0006508,GO:0006513,GO:0010506,GO:0014066,GO:0016020,GO:0016032,GO:0016567,GO:0019005,GO:0019903,GO:0031146,GO:0036312,GO:0044830" protein binding|calmodulin binding|cytoplasm|cellular protein modification process|proteolysis|protein monoubiquitination|regulation of autophagy|regulation of phosphatidylinositol 3-kinase signaling|membrane|viral process|protein ubiquitination|SCF ubiquitin ligase complex|protein phosphatase binding|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|phosphatidylinositol 3-kinase regulatory subunit binding|modulation by host of viral RNA genome replication FBXL20 509.9297917 505.641147 514.2184365 1.016963195 0.024267468 0.936641329 1 2.51821003 2.518073275 84961 F-box and leucine rich repeat protein 20 "GO:0000209,GO:0005515,GO:0005829,GO:0019005,GO:0031146,GO:0043687" protein polyubiquitination|protein binding|cytosol|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification FBXL22 4.523346619 5.202069413 3.844623824 0.739056617 -0.436243205 0.933440272 1 0.08847192 0.064291616 283807 F-box and leucine rich repeat protein 22 "GO:0000086,GO:0000209,GO:0005515,GO:0005634,GO:0005730,GO:0005829,GO:0019005,GO:0030018,GO:0031146,GO:0043153,GO:0043161,GO:0043687,GO:0051726,GO:0061630" G2/M transition of mitotic cell cycle|protein polyubiquitination|protein binding|nucleus|nucleolus|cytosol|SCF ubiquitin ligase complex|Z disc|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|entrainment of circadian clock by photoperiod|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|regulation of cell cycle|ubiquitin protein ligase activity FBXL3 846.7980199 845.8564866 847.7395532 1.002226225 0.003208194 0.995189508 1 11.67661823 11.50678562 26224 F-box and leucine rich repeat protein 3 "GO:0000086,GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005829,GO:0016567,GO:0016604,GO:0019005,GO:0031146,GO:0031648,GO:0042752,GO:0043153,GO:0043687,GO:0048511,GO:0051726" G2/M transition of mitotic cell cycle|ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|cytosol|protein ubiquitination|nuclear body|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein destabilization|regulation of circadian rhythm|entrainment of circadian clock by photoperiod|post-translational protein modification|rhythmic process|regulation of cell cycle hsa04710 Circadian rhythm FBXL4 591.1172875 580.5509465 601.6836285 1.036401081 0.051582425 0.850981118 1 3.756873652 3.828473323 26235 F-box and leucine rich repeat protein 4 "GO:0000151,GO:0000209,GO:0005515,GO:0005758,GO:0005829,GO:0006511,GO:0016607,GO:0019005,GO:0031146,GO:0043687" ubiquitin ligase complex|protein polyubiquitination|protein binding|mitochondrial intermembrane space|cytosol|ubiquitin-dependent protein catabolic process|nuclear speck|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification FBXL5 1906.84813 1801.996845 2011.699416 1.11637233 0.158818272 0.50314067 1 21.09900388 23.16019407 26234 F-box and leucine rich repeat protein 5 "GO:0000151,GO:0000209,GO:0004842,GO:0005506,GO:0005515,GO:0005829,GO:0006879,GO:0016567,GO:0019005,GO:0031146,GO:0043687,GO:0048471,GO:0055072,GO:1903364" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|iron ion binding|protein binding|cytosol|cellular iron ion homeostasis|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|perinuclear region of cytoplasm|iron ion homeostasis|positive regulation of cellular protein catabolic process FBXL6 405.3675821 397.4381032 413.2970611 1.039902963 0.056448912 0.852825069 1 12.15503788 12.42854562 26233 F-box and leucine rich repeat protein 6 "GO:0000086,GO:0004842,GO:0005634,GO:0005829,GO:0006508,GO:0016567,GO:0019005,GO:0031146,GO:0043153,GO:0051726" G2/M transition of mitotic cell cycle|ubiquitin-protein transferase activity|nucleus|cytosol|proteolysis|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|entrainment of circadian clock by photoperiod|regulation of cell cycle FBXL7 2.883467868 0 5.766935736 Inf Inf 0.126446699 1 0 0.031252776 23194 F-box and leucine rich repeat protein 7 "GO:0000086,GO:0000151,GO:0000209,GO:0000278,GO:0005515,GO:0005813,GO:0005829,GO:0006511,GO:0010265,GO:0010972,GO:0016567,GO:0019005,GO:0031146,GO:0043687,GO:0051301" G2/M transition of mitotic cell cycle|ubiquitin ligase complex|protein polyubiquitination|mitotic cell cycle|protein binding|centrosome|cytosol|ubiquitin-dependent protein catabolic process|SCF complex assembly|negative regulation of G2/M transition of mitotic cell cycle|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|cell division FBXL8 99.84071815 97.79890497 101.8825313 1.041755338 0.059016493 0.922118464 1 3.202053872 3.279937344 55336 F-box and leucine rich repeat protein 8 "GO:0000086,GO:0000209,GO:0005515,GO:0005634,GO:0005829,GO:0019005,GO:0031146,GO:0043153,GO:0043687,GO:0051726" G2/M transition of mitotic cell cycle|protein polyubiquitination|protein binding|nucleus|cytosol|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|entrainment of circadian clock by photoperiod|post-translational protein modification|regulation of cell cycle FBXO10 307.7410555 370.3873422 245.0947688 0.661725553 -0.595695104 0.05612957 1 3.513489462 2.286060603 26267 F-box protein 10 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0006511,GO:0006915,GO:0016567,GO:0042981,GO:0043687" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|apoptotic process|protein ubiquitination|regulation of apoptotic process|post-translational protein modification FBXO11 1445.485668 1423.286191 1467.685145 1.031194677 0.044316722 0.855639316 1 18.02519415 18.27644789 80204 F-box protein 11 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0005829,GO:0006464,GO:0006511,GO:0007605,GO:0008270,GO:0016274,GO:0016567,GO:0035246,GO:0042981,GO:0043687" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|cytoplasm|cytosol|cellular protein modification process|ubiquitin-dependent protein catabolic process|sensory perception of sound|zinc ion binding|protein-arginine N-methyltransferase activity|protein ubiquitination|peptidyl-arginine N-methylation|regulation of apoptotic process|post-translational protein modification FBXO15 12.97057499 12.48496659 13.45618338 1.0777909 0.108077311 1 1 0.056880632 0.060279564 201456 F-box protein 15 "GO:0000209,GO:0005515,GO:0005829,GO:0043687" protein polyubiquitination|protein binding|cytosol|post-translational protein modification FBXO16 77.90270785 76.99062732 78.81478839 1.023693288 0.033783529 0.975508478 1 3.276593522 3.298098352 157574 F-box protein 16 GO:0005515 protein binding FBXO17 514.4380471 548.2981162 480.577978 0.876490296 -0.190189977 0.486210422 1 12.54250438 10.809424 115290 F-box protein 17 "GO:0000209,GO:0005515,GO:0005737,GO:0005829,GO:0006516,GO:0019005,GO:0030433,GO:0031146,GO:0043687,GO:0061630" protein polyubiquitination|protein binding|cytoplasm|cytosol|glycoprotein catabolic process|SCF ubiquitin ligase complex|ubiquitin-dependent ERAD pathway|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|ubiquitin protein ligase activity FBXO2 242.4182778 182.0724295 302.7641261 1.662877389 0.733681797 0.030460871 0.895820653 7.550016259 12.34466456 26232 F-box protein 2 "GO:0000209,GO:0001540,GO:0004842,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0006464,GO:0006508,GO:0006516,GO:0008285,GO:0016567,GO:0019005,GO:0030246,GO:0030433,GO:0031090,GO:0031146,GO:0031396,GO:0043197,GO:0043687,GO:0061630" protein polyubiquitination|amyloid-beta binding|ubiquitin-protein transferase activity|protein binding|cytoplasm|endoplasmic reticulum|cytosol|cellular protein modification process|proteolysis|glycoprotein catabolic process|negative regulation of cell population proliferation|protein ubiquitination|SCF ubiquitin ligase complex|carbohydrate binding|ubiquitin-dependent ERAD pathway|organelle membrane|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of protein ubiquitination|dendritic spine|post-translational protein modification|ubiquitin protein ligase activity "hsa04120,hsa04141" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum FBXO21 1290.10108 1318.204389 1261.99777 0.957361226 -0.062864718 0.796696828 1 11.711361 11.02438524 23014 F-box protein 21 "GO:0000151,GO:0000209,GO:0003677,GO:0004842,GO:0005829,GO:0006511,GO:0043687" ubiquitin ligase complex|protein polyubiquitination|DNA binding|ubiquitin-protein transferase activity|cytosol|ubiquitin-dependent protein catabolic process|post-translational protein modification FBXO22 855.478606 770.946687 940.010525 1.219293812 0.286045813 0.252298917 1 17.24392613 20.67358062 26263 F-box protein 22 "GO:0000209,GO:0004842,GO:0005515,GO:0005829,GO:0006464,GO:0006511,GO:0030018,GO:0032436,GO:0043687,GO:0048742" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytosol|cellular protein modification process|ubiquitin-dependent protein catabolic process|Z disc|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|regulation of skeletal muscle fiber development hsa05132 Salmonella infection FBXO24 10.88974722 8.323311061 13.45618338 1.616686351 0.693039812 0.572357607 1 0.085177337 0.135400731 26261 F-box protein 24 "GO:0000151,GO:0004842,GO:0005515,GO:0016567" ubiquitin ligase complex|ubiquitin-protein transferase activity|protein binding|protein ubiquitination FBXO25 168.7017632 151.9004269 185.5030995 1.22121513 0.288317368 0.462831028 1 4.427442163 5.316382887 26260 F-box protein 25 "GO:0000151,GO:0003779,GO:0004842,GO:0005634,GO:0005730,GO:0016567,GO:0019005" ubiquitin ligase complex|actin binding|ubiquitin-protein transferase activity|nucleus|nucleolus|protein ubiquitination|SCF ubiquitin ligase complex hsa04068 FoxO signaling pathway FBXO27 645.1099833 660.6628155 629.5571512 0.952917489 -0.069576795 0.793710953 1 12.58328345 11.79018055 126433 F-box protein 27 "GO:0000209,GO:0005515,GO:0005737,GO:0005829,GO:0006516,GO:0019005,GO:0030433,GO:0031146,GO:0043687,GO:0061630" protein polyubiquitination|protein binding|cytoplasm|cytosol|glycoprotein catabolic process|SCF ubiquitin ligase complex|ubiquitin-dependent ERAD pathway|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|ubiquitin protein ligase activity FBXO28 1724.119058 1874.825817 1573.4123 0.839231189 -0.252859799 0.286870824 1 18.43670684 15.21374541 23219 F-box protein 28 "GO:0000209,GO:0000776,GO:0000777,GO:0005515,GO:0042802" protein polyubiquitination|kinetochore|condensed chromosome kinetochore|protein binding|identical protein binding FBXO3 923.2445169 859.3818671 987.1071668 1.148624616 0.199907385 0.420771917 1 9.338959635 10.54745779 26273 F-box protein 3 "GO:0004842,GO:0005515,GO:0005654,GO:0005829,GO:0006508,GO:0016567" ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytosol|proteolysis|protein ubiquitination FBXO30 590.1460707 605.5208797 574.7712617 0.949217906 -0.075188779 0.780939 1 2.281204041 2.129125362 84085 F-box protein 30 "GO:0000209,GO:0005829,GO:0008270,GO:0043687,GO:0061630" protein polyubiquitination|cytosol|zinc ion binding|post-translational protein modification|ubiquitin protein ligase activity FBXO31 754.1364033 722.0472346 786.225572 1.088883849 0.12285007 0.631081686 1 6.31296426 6.759056322 79791 F-box protein 31 "GO:0000209,GO:0005515,GO:0005813,GO:0005829,GO:0006974,GO:0019005,GO:0030332,GO:0031145,GO:0031146,GO:0031571,GO:0043025,GO:0043687,GO:0050775,GO:2001224" protein polyubiquitination|protein binding|centrosome|cytosol|cellular response to DNA damage stimulus|SCF ubiquitin ligase complex|cyclin binding|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|mitotic G1 DNA damage checkpoint|neuronal cell body|post-translational protein modification|positive regulation of dendrite morphogenesis|positive regulation of neuron migration FBXO32 249.4476956 328.7707869 170.1246042 0.517456572 -0.950490308 0.004702454 0.414877795 2.543989074 1.294375628 114907 F-box protein 32 "GO:0000209,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0014894,GO:0016567,GO:0019005,GO:0030018,GO:0043687,GO:0071549" protein polyubiquitination|protein binding|nucleoplasm|cytoplasm|cytosol|response to denervation involved in regulation of muscle adaptation|protein ubiquitination|SCF ubiquitin ligase complex|Z disc|post-translational protein modification|cellular response to dexamethasone stimulus hsa04068 FoxO signaling pathway FBXO33 686.3358938 620.0866741 752.5851135 1.213677289 0.279384867 0.277558214 1 6.427051102 7.669837397 254170 F-box protein 33 "GO:0005515,GO:0016567,GO:0019005,GO:0031146" protein binding|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process FBXO34 901.1178083 909.3217334 892.9138831 0.981955946 -0.026269793 0.920373563 1 8.165712544 7.884193425 55030 F-box protein 34 GO:0005515 protein binding FBXO36 184.7092915 181.0320156 188.3865674 1.040625697 0.057451238 0.89271136 1 2.58601337 2.64604052 130888 F-box protein 36 FBXO38 1230.049569 1167.344376 1292.754761 1.107432209 0.147218387 0.543816978 1 10.99135919 11.96850015 81545 F-box protein 38 "GO:0002250,GO:0002842,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0010976,GO:0019005,GO:0031146,GO:0070936" adaptive immune response|positive regulation of T cell mediated immune response to tumor cell|protein binding|nucleus|cytoplasm|cytosol|positive regulation of neuron projection development|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination FBXO4 256.5676609 250.7397457 262.395576 1.04648577 0.065552695 0.854697187 1 1.258016301 1.294466377 26272 F-box protein 4 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0007568,GO:0010608,GO:0016567,GO:0019005,GO:0019725,GO:0031146,GO:0031398,GO:0031647,GO:0031648,GO:0032212,GO:0035726,GO:0042803,GO:0043687,GO:0048147,GO:0061630,GO:0071479,GO:1900181,GO:1902916,GO:2000001" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|aging|posttranscriptional regulation of gene expression|protein ubiquitination|SCF ubiquitin ligase complex|cellular homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|regulation of protein stability|protein destabilization|positive regulation of telomere maintenance via telomerase|common myeloid progenitor cell proliferation|protein homodimerization activity|post-translational protein modification|negative regulation of fibroblast proliferation|ubiquitin protein ligase activity|cellular response to ionizing radiation|negative regulation of protein localization to nucleus|positive regulation of protein polyubiquitination|regulation of DNA damage checkpoint hsa04120 Ubiquitin mediated proteolysis FBXO41 548.7867965 579.5105326 518.0630603 0.8939666 -0.161707165 0.548915959 1 3.1287215 2.750168973 150726 F-box protein 41 "GO:0000209,GO:0005829,GO:0043687" protein polyubiquitination|cytosol|post-translational protein modification FBXO42 386.0205457 406.8018281 365.2392633 0.897830929 -0.155484299 0.599245883 1 3.404463838 3.005484318 54455 F-box protein 42 GO:0005515 protein binding FBXO43 291.9813618 322.5283036 261.43442 0.810578226 -0.302976674 0.341370409 1 5.447070501 4.341393064 286151 F-box protein 43 "GO:0005515,GO:0005634,GO:0007088,GO:0016567,GO:0045835,GO:0046872,GO:0051321" protein binding|nucleus|regulation of mitotic nuclear division|protein ubiquitination|negative regulation of meiotic nuclear division|metal ion binding|meiotic cell cycle hsa04114 Oocyte meiosis FBXO44 524.3622223 468.1862472 580.5381974 1.239972769 0.310308438 0.251709738 1 10.07509658 12.28379456 93611 F-box protein 44 "GO:0000209,GO:0005515,GO:0005737,GO:0005829,GO:0006516,GO:0010498,GO:0019005,GO:0030433,GO:0031146,GO:0043687,GO:0061630" protein polyubiquitination|protein binding|cytoplasm|cytosol|glycoprotein catabolic process|proteasomal protein catabolic process|SCF ubiquitin ligase complex|ubiquitin-dependent ERAD pathway|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|ubiquitin protein ligase activity FBXO45 992.442101 972.7869803 1012.097222 1.040409917 0.057152056 0.819901448 1 8.759212625 8.960675096 200933 F-box protein 45 "GO:0001764,GO:0005515,GO:0006511,GO:0006974,GO:0014069,GO:0016567,GO:0019005,GO:0021799,GO:0021800,GO:0021957,GO:0021960,GO:0042734,GO:0042995,GO:0043161,GO:0045202,GO:0045211,GO:0060386,GO:0098978,GO:0099523,GO:0099524" neuron migration|protein binding|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|postsynaptic density|protein ubiquitination|SCF ubiquitin ligase complex|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration|corticospinal tract morphogenesis|anterior commissure morphogenesis|presynaptic membrane|cell projection|proteasome-mediated ubiquitin-dependent protein catabolic process|synapse|postsynaptic membrane|synapse assembly involved in innervation|glutamatergic synapse|presynaptic cytosol|postsynaptic cytosol FBXO46 238.3453267 251.7801596 224.9104937 0.893281242 -0.162813628 0.640144359 1 3.564202749 3.130558284 23403 F-box protein 46 GO:0005515 protein binding FBXO48 145.3515871 157.1024963 133.6006779 0.850404551 -0.233778777 0.577308129 1 1.461438293 1.22201697 554251 F-box protein 48 "GO:0005515,GO:0019005,GO:0031146" protein binding|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process FBXO5 836.661223 857.3010393 816.0214066 0.951849315 -0.071194894 0.779976081 1 19.06357534 17.84200822 26271 F-box protein 5 "GO:0000083,GO:0001556,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005819,GO:0005829,GO:0006275,GO:0007057,GO:0007088,GO:0007346,GO:0008284,GO:0010971,GO:0010997,GO:0016050,GO:0016567,GO:0019901,GO:0031145,GO:0032876,GO:0045669,GO:0045835,GO:0045841,GO:0046785,GO:0046872,GO:0051301,GO:0051444,GO:0070169,GO:0072687,GO:1901990,GO:1904667,GO:1905322,GO:1990948,GO:2000773,GO:2001021" regulation of transcription involved in G1/S transition of mitotic cell cycle|oocyte maturation|protein binding|nucleus|nucleoplasm|cytoplasm|spindle|cytosol|regulation of DNA replication|spindle assembly involved in female meiosis I|regulation of mitotic nuclear division|regulation of mitotic cell cycle|positive regulation of cell population proliferation|positive regulation of G2/M transition of mitotic cell cycle|anaphase-promoting complex binding|vesicle organization|protein ubiquitination|protein kinase binding|anaphase-promoting complex-dependent catabolic process|negative regulation of DNA endoreduplication|positive regulation of osteoblast differentiation|negative regulation of meiotic nuclear division|negative regulation of mitotic metaphase/anaphase transition|microtubule polymerization|metal ion binding|cell division|negative regulation of ubiquitin-protein transferase activity|positive regulation of biomineral tissue development|meiotic spindle|regulation of mitotic cell cycle phase transition|negative regulation of ubiquitin protein ligase activity|positive regulation of mesenchymal stem cell migration|ubiquitin ligase inhibitor activity|negative regulation of cellular senescence|negative regulation of response to DNA damage stimulus hsa04114 Oocyte meiosis FBXO6 82.82737452 80.11186896 85.54288008 1.06779284 0.09463178 0.873459019 1 2.217543157 2.328253496 26270 F-box protein 6 "GO:0000077,GO:0000209,GO:0005515,GO:0005737,GO:0005829,GO:0006281,GO:0006508,GO:0006516,GO:0006986,GO:0019005,GO:0030246,GO:0030433,GO:0031146,GO:0043687,GO:0044322,GO:0061630" DNA damage checkpoint|protein polyubiquitination|protein binding|cytoplasm|cytosol|DNA repair|proteolysis|glycoprotein catabolic process|response to unfolded protein|SCF ubiquitin ligase complex|carbohydrate binding|ubiquitin-dependent ERAD pathway|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|endoplasmic reticulum quality control compartment|ubiquitin protein ligase activity hsa04141 Protein processing in endoplasmic reticulum FBXO7 1966.949331 1928.927338 2004.971324 1.03942294 0.055782804 0.815489885 1 44.37211501 45.34961515 25793 F-box protein 7 "GO:0000151,GO:0000209,GO:0000422,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006511,GO:0006626,GO:0010975,GO:0016567,GO:0019005,GO:0019901,GO:0031625,GO:0031647,GO:0032991,GO:0040012,GO:0043130,GO:0043687,GO:0045620,GO:0045736,GO:0046982,GO:0097409,GO:0097414,GO:0097462,GO:1903204,GO:1903599,GO:1990037,GO:1990038,GO:1990756,GO:2000134" ubiquitin ligase complex|protein polyubiquitination|autophagy of mitochondrion|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|ubiquitin-dependent protein catabolic process|protein targeting to mitochondrion|regulation of neuron projection development|protein ubiquitination|SCF ubiquitin ligase complex|protein kinase binding|ubiquitin protein ligase binding|regulation of protein stability|protein-containing complex|regulation of locomotion|ubiquitin binding|post-translational protein modification|negative regulation of lymphocyte differentiation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|protein heterodimerization activity|glial cytoplasmic inclusion|classical Lewy body|Lewy neurite|negative regulation of oxidative stress-induced neuron death|positive regulation of autophagy of mitochondrion|Lewy body core|Lewy body corona|ubiquitin ligase-substrate adaptor activity|negative regulation of G1/S transition of mitotic cell cycle FBXO8 342.0111613 298.5987843 385.4235384 1.29077397 0.36823639 0.223978224 1 7.639342434 9.6956595 26269 F-box protein 8 "GO:0000151,GO:0005085,GO:0006511,GO:0032012,GO:0050790" ubiquitin ligase complex|guanyl-nucleotide exchange factor activity|ubiquitin-dependent protein catabolic process|regulation of ARF protein signal transduction|regulation of catalytic activity FBXO9 672.0223501 660.6628155 683.3818847 1.034388297 0.048777858 0.855423484 1 6.748011524 6.863262229 26268 F-box protein 9 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0016567,GO:0019005,GO:0031146,GO:0032006,GO:0043687,GO:0045087,GO:0045444" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of TOR signaling|post-translational protein modification|innate immune response|fat cell differentiation FBXW11 2310.09084 2105.797698 2514.383981 1.194029219 0.255838141 0.27921631 1 22.36023734 26.25200885 23291 F-box and WD repeat domain containing 11 "GO:0000086,GO:0000132,GO:0000151,GO:0000209,GO:0000776,GO:0002223,GO:0004842,GO:0005515,GO:0005634,GO:0005635,GO:0005813,GO:0005829,GO:0005875,GO:0005881,GO:0006470,GO:0007097,GO:0007281,GO:0008090,GO:0016032,GO:0016055,GO:0016567,GO:0019005,GO:0031023,GO:0031146,GO:0031648,GO:0038061,GO:0038095,GO:0042753,GO:0043005,GO:0043025,GO:0043161,GO:0043687,GO:0045862,GO:0045892,GO:0045893,GO:0046983,GO:0047496,GO:0048511,GO:0048854,GO:0050852,GO:0051010,GO:0051403,GO:0070498,GO:0070840,GO:1904115,GO:2000574" "G2/M transition of mitotic cell cycle|establishment of mitotic spindle orientation|ubiquitin ligase complex|protein polyubiquitination|kinetochore|stimulatory C-type lectin receptor signaling pathway|ubiquitin-protein transferase activity|protein binding|nucleus|nuclear envelope|centrosome|cytosol|microtubule associated complex|cytoplasmic microtubule|protein dephosphorylation|nuclear migration|germ cell development|retrograde axonal transport|viral process|Wnt signaling pathway|protein ubiquitination|SCF ubiquitin ligase complex|microtubule organizing center organization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein destabilization|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|positive regulation of circadian rhythm|neuron projection|neuronal cell body|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|positive regulation of proteolysis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein dimerization activity|vesicle transport along microtubule|rhythmic process|brain morphogenesis|T cell receptor signaling pathway|microtubule plus-end binding|stress-activated MAPK cascade|interleukin-1-mediated signaling pathway|dynein complex binding|axon cytoplasm|regulation of microtubule motor activity" "hsa04114,hsa04120,hsa04218,hsa04310,hsa04340,hsa04390,hsa04710,hsa05131,hsa05170" Oocyte meiosis|Ubiquitin mediated proteolysis|Cellular senescence|Wnt signaling pathway|Hedgehog signaling pathway|Hippo signaling pathway|Circadian rhythm|Shigellosis|Human immunodeficiency virus 1 infection FBXW2 2220.627879 2293.072197 2148.183562 0.936814621 -0.094164502 0.691535687 1 13.17724224 12.13806248 26190 F-box and WD repeat domain containing 2 "GO:0000209,GO:0004842,GO:0005515,GO:0005829,GO:0006464,GO:0006508,GO:0043687" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytosol|cellular protein modification process|proteolysis|post-translational protein modification FBXW4 916.125166 836.4927616 995.7575704 1.19039592 0.251441487 0.310989518 1 19.70952816 23.06953473 6468 F-box and WD repeat domain containing 4 "GO:0000151,GO:0000209,GO:0005515,GO:0005829,GO:0006511,GO:0016055,GO:0019005,GO:0030326,GO:0031146,GO:0043687" ubiquitin ligase complex|protein polyubiquitination|protein binding|cytosol|ubiquitin-dependent protein catabolic process|Wnt signaling pathway|SCF ubiquitin ligase complex|embryonic limb morphogenesis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification FBXW5 1605.40808 1597.03531 1613.78085 1.010485391 0.015048465 0.952407666 1 37.82993309 37.58692445 54461 F-box and WD repeat domain containing 5 "GO:0000209,GO:0005515,GO:0005737,GO:0005829,GO:0007088,GO:0010824,GO:0016567,GO:0019005,GO:0019901,GO:0031146,GO:0043161,GO:0043687,GO:0080008" protein polyubiquitination|protein binding|cytoplasm|cytosol|regulation of mitotic nuclear division|regulation of centrosome duplication|protein ubiquitination|SCF ubiquitin ligase complex|protein kinase binding|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex FBXW7 220.8564355 221.608157 220.1047139 0.993215759 -0.009820942 0.992373271 1 2.032798219 1.985221875 55294 F-box and WD repeat domain containing 7 "GO:0000209,GO:0001570,GO:0001944,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005783,GO:0005794,GO:0005829,GO:0007062,GO:0007219,GO:0010629,GO:0010868,GO:0010883,GO:0010992,GO:0016032,GO:0016567,GO:0019005,GO:0030324,GO:0030332,GO:0030674,GO:0031146,GO:0031398,GO:0031625,GO:0031648,GO:0032880,GO:0042752,GO:0042802,GO:0043130,GO:0043161,GO:0043687,GO:0045741,GO:0045746,GO:0048471,GO:0048511,GO:0050816,GO:0050821,GO:0051443,GO:0055088,GO:0070374,GO:0090049,GO:0097027,GO:1901800,GO:1902806,GO:1903026,GO:1903146,GO:1903378,GO:1903955,GO:1990452,GO:2000060,GO:2000346,GO:2000639,GO:2001205" protein polyubiquitination|vasculogenesis|vasculature development|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|endoplasmic reticulum|Golgi apparatus|cytosol|sister chromatid cohesion|Notch signaling pathway|negative regulation of gene expression|negative regulation of triglyceride biosynthetic process|regulation of lipid storage|ubiquitin recycling|viral process|protein ubiquitination|SCF ubiquitin ligase complex|lung development|cyclin binding|protein-macromolecule adaptor activity|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|protein destabilization|regulation of protein localization|regulation of circadian rhythm|identical protein binding|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|positive regulation of epidermal growth factor-activated receptor activity|negative regulation of Notch signaling pathway|perinuclear region of cytoplasm|rhythmic process|phosphothreonine residue binding|protein stabilization|positive regulation of ubiquitin-protein transferase activity|lipid homeostasis|positive regulation of ERK1 and ERK2 cascade|regulation of cell migration involved in sprouting angiogenesis|ubiquitin-protein transferase activator activity|positive regulation of proteasomal protein catabolic process|regulation of cell cycle G1/S phase transition|negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding|regulation of autophagy of mitochondrion|positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|positive regulation of protein targeting to mitochondrion|Parkin-FBXW7-Cul1 ubiquitin ligase complex|positive regulation of ubiquitin-dependent protein catabolic process|negative regulation of hepatocyte proliferation|negative regulation of SREBP signaling pathway|negative regulation of osteoclast development hsa04120 Ubiquitin mediated proteolysis FBXW8 694.1377692 837.5331755 550.7423628 0.657576773 -0.604768754 0.018434467 0.780468537 5.476305594 3.540831973 26259 F-box and WD repeat domain containing 8 "GO:0000209,GO:0004842,GO:0005515,GO:0005794,GO:0005829,GO:0007030,GO:0008283,GO:0016567,GO:0019005,GO:0031467,GO:0043687,GO:0048471,GO:0050775,GO:0060716,GO:1901485,GO:1990393" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|Golgi apparatus|cytosol|Golgi organization|cell population proliferation|protein ubiquitination|SCF ubiquitin ligase complex|Cul7-RING ubiquitin ligase complex|post-translational protein modification|perinuclear region of cytoplasm|positive regulation of dendrite morphogenesis|labyrinthine layer blood vessel development|positive regulation of transcription factor catabolic process|3M complex hsa04120 Ubiquitin mediated proteolysis FBXW9 90.90788139 103.0009744 78.81478839 0.765184882 -0.386119725 0.431122894 1 3.182960449 2.39479753 84261 F-box and WD repeat domain containing 9 "GO:0000209,GO:0005515,GO:0005829,GO:0030687,GO:0043687" "protein polyubiquitination|protein binding|cytosol|preribosome, large subunit precursor|post-translational protein modification" FCF1 967.1696129 977.9890497 956.3501762 0.977874115 -0.032279341 0.900058748 1 34.86538284 33.52343921 51077 FCF1 rRNA-processing protein "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0032040" RNA binding|protein binding|nucleoplasm|nucleolus|rRNA processing|small-subunit processome hsa03008 Ribosome biogenesis in eukaryotes FCGR2A 4.003139677 4.161655531 3.844623824 0.923820772 -0.11431511 1 1 0.061218276 0.055608349 2212 Fc fragment of IgG receptor IIa "GO:0004888,GO:0005515,GO:0005794,GO:0005886,GO:0005887,GO:0007166,GO:0019864,GO:0030667,GO:0038096,GO:0043312,GO:0050776" transmembrane signaling receptor activity|protein binding|Golgi apparatus|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|IgG binding|secretory granule membrane|Fc-gamma receptor signaling pathway involved in phagocytosis|neutrophil degranulation|regulation of immune response "hsa04145,hsa04380,hsa04611,hsa04666,hsa05130,hsa05135,hsa05140,hsa05150,hsa05152,hsa05171,hsa05322" Phagosome|Osteoclast differentiation|Platelet activation|Fc gamma R-mediated phagocytosis|Pathogenic Escherichia coli infection|Yersinia infection|Leishmaniasis|Staphylococcus aureus infection|Tuberculosis|Coronavirus disease - COVID-19|Systemic lupus erythematosus FCGRT 594.4266131 616.9654324 571.8877938 0.926936525 -0.109457546 0.682028886 1 20.17543578 18.38840659 2217 Fc fragment of IgG receptor and transporter "GO:0002416,GO:0005515,GO:0005615,GO:0006955,GO:0009897,GO:0010008,GO:0016021,GO:0019864,GO:0030881,GO:0042605" IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor|protein binding|extracellular space|immune response|external side of plasma membrane|endosome membrane|integral component of membrane|IgG binding|beta-2-microglobulin binding|peptide antigen binding FCHO1 108.4860913 110.2838716 106.6883111 0.967397223 -0.047819698 0.937806777 1 1.565748213 1.489354012 23149 FCH and mu domain containing endocytic adaptor 1 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005905,GO:0030136,GO:0035612,GO:0048268,GO:0061024,GO:0072583" protein binding|nucleoplasm|cytoplasm|cytosol|cytoskeleton|plasma membrane|clathrin-coated pit|clathrin-coated vesicle|AP-2 adaptor complex binding|clathrin coat assembly|membrane organization|clathrin-dependent endocytosis FCHO2 852.0988545 909.3217334 794.8759756 0.874141623 -0.19406106 0.438465236 1 8.426606989 7.242787071 115548 FCH and mu domain containing endocytic adaptor 2 "GO:0001786,GO:0005515,GO:0005546,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005905,GO:0010324,GO:0030136,GO:0035091,GO:0042802,GO:0048268,GO:0048488,GO:0061024,GO:0072583,GO:0072659,GO:0098835" "phosphatidylserine binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|clathrin-coated pit|membrane invagination|clathrin-coated vesicle|phosphatidylinositol binding|identical protein binding|clathrin coat assembly|synaptic vesicle endocytosis|membrane organization|clathrin-dependent endocytosis|protein localization to plasma membrane|presynaptic endocytic zone membrane" FCHSD1 1308.606462 1211.041759 1406.171164 1.161125248 0.215523601 0.370844527 1 14.02279733 16.00976306 89848 FCH and double SH3 domains 1 "GO:0007274,GO:0008289,GO:0030833,GO:0030838,GO:0031594,GO:0032437,GO:0042995,GO:0043204,GO:0044803,GO:0055037" neuromuscular synaptic transmission|lipid binding|regulation of actin filament polymerization|positive regulation of actin filament polymerization|neuromuscular junction|cuticular plate|cell projection|perikaryon|multi-organism membrane organization|recycling endosome FCHSD2 1005.685048 1005.039811 1006.330286 1.001284004 0.001851238 0.99865879 1 10.29701046 10.1377041 9873 FCH and double SH3 domains 2 "GO:0005515,GO:0005547,GO:0005886,GO:0005905,GO:0007274,GO:0015031,GO:0030833,GO:0030838,GO:0031594,GO:0043325,GO:0055037,GO:0072583,GO:0120043,GO:2000601" "protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|plasma membrane|clathrin-coated pit|neuromuscular synaptic transmission|protein transport|regulation of actin filament polymerization|positive regulation of actin filament polymerization|neuromuscular junction|phosphatidylinositol-3,4-bisphosphate binding|recycling endosome|clathrin-dependent endocytosis|stereocilium shaft|positive regulation of Arp2/3 complex-mediated actin nucleation" FCMR 91.67089253 97.79890497 85.54288008 0.874681369 -0.193170531 0.704670915 1 1.741524128 1.497788702 9214 Fc fragment of IgM receptor "GO:0002376,GO:0004888,GO:0005576,GO:0005886,GO:0006968,GO:0016021,GO:0043066" immune system process|transmembrane signaling receptor activity|extracellular region|plasma membrane|cellular defense response|integral component of membrane|negative regulation of apoptotic process FCRLA 4.042768641 5.202069413 2.883467868 0.554292463 -0.851280704 0.745112452 1 0.120028052 0.065417344 84824 Fc receptor like A "GO:0004888,GO:0005737,GO:0005887,GO:0007166,GO:0030154" transmembrane signaling receptor activity|cytoplasm|integral component of plasma membrane|cell surface receptor signaling pathway|cell differentiation FCRLB 53.72535394 47.8590386 59.59166927 1.245149736 0.316319244 0.605833768 1 1.261931289 1.544999944 127943 Fc receptor like B "GO:0004888,GO:0005737,GO:0005783,GO:0005887,GO:0007166,GO:0050777" transmembrane signaling receptor activity|cytoplasm|endoplasmic reticulum|integral component of plasma membrane|cell surface receptor signaling pathway|negative regulation of immune response FCSK 233.0092791 275.7096789 190.3088793 0.690250992 -0.534807039 0.119109897 1 2.878348754 1.953536958 197258 fucose kinase "GO:0005515,GO:0005524,GO:0005829,GO:0042352,GO:0046835,GO:0050201,GO:1903350" protein binding|ATP binding|cytosol|GDP-L-fucose salvage|carbohydrate phosphorylation|fucokinase activity|response to dopamine "hsa00051,hsa00520" Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism FDFT1 1845.170603 1810.320156 1880.02105 1.038501971 0.054503954 0.820040608 1 23.06360933 23.5508061 2222 farnesyl-diphosphate farnesyltransferase 1 "GO:0004310,GO:0005515,GO:0005783,GO:0005789,GO:0006694,GO:0006695,GO:0016021,GO:0019216,GO:0045338,GO:0045540,GO:0046872,GO:0051996" farnesyl-diphosphate farnesyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|steroid biosynthetic process|cholesterol biosynthetic process|integral component of membrane|regulation of lipid metabolic process|farnesyl diphosphate metabolic process|regulation of cholesterol biosynthetic process|metal ion binding|squalene synthase activity hsa00100 Steroid biosynthesis FDPS 2426.156738 2288.910542 2563.402935 1.119922726 0.163399191 0.489873725 1 71.94048809 79.21959475 2224 farnesyl diphosphate synthase "GO:0003723,GO:0004161,GO:0004337,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006695,GO:0016032,GO:0033384,GO:0045337,GO:0045540,GO:0046872" RNA binding|dimethylallyltranstransferase activity|geranyltranstransferase activity|protein binding|nucleoplasm|cytoplasm|cytosol|cholesterol biosynthetic process|viral process|geranyl diphosphate biosynthetic process|farnesyl diphosphate biosynthetic process|regulation of cholesterol biosynthetic process|metal ion binding "hsa00900,hsa05164,hsa05166" Terpenoid backbone biosynthesis|Influenza A|Human T-cell leukemia virus 1 infection FDX1 413.5820671 385.9935505 441.1705838 1.142948071 0.192759857 0.504703635 1 6.552088538 7.363383751 2230 ferredoxin 1 "GO:0005506,GO:0005739,GO:0005759,GO:0006700,GO:0008203,GO:0009055,GO:0016125,GO:0022900,GO:0042446,GO:0044281,GO:0051537,GO:0071320,GO:1904322" "iron ion binding|mitochondrion|mitochondrial matrix|C21-steroid hormone biosynthetic process|cholesterol metabolic process|electron transfer activity|sterol metabolic process|electron transport chain|hormone biosynthetic process|small molecule metabolic process|2 iron, 2 sulfur cluster binding|cellular response to cAMP|cellular response to forskolin" FDX2 206.6869307 202.8807071 210.4931544 1.03752179 0.053141636 0.895968204 1 10.69898267 10.91467702 112812 ferredoxin 2 "GO:0005515,GO:0005759,GO:0006700,GO:0009055,GO:0016125,GO:0022900,GO:0044281,GO:0046872,GO:0051537" "protein binding|mitochondrial matrix|C21-steroid hormone biosynthetic process|electron transfer activity|sterol metabolic process|electron transport chain|small molecule metabolic process|metal ion binding|2 iron, 2 sulfur cluster binding" FDXACB1 64.49118385 65.54607461 63.4362931 0.967812237 -0.047200914 0.962285232 1 1.261021461 1.200009725 91893 ferredoxin-fold anticodon binding domain containing 1 "GO:0005515,GO:0005737,GO:0070042,GO:0070475" protein binding|cytoplasm|rRNA (uridine-N3-)-methyltransferase activity|rRNA base methylation FDXR 508.9290068 504.6007331 513.2572805 1.017155241 0.024539885 0.935881824 1 12.53706411 12.53875067 2232 ferredoxin reductase "GO:0004324,GO:0005739,GO:0005743,GO:0005759,GO:0006091,GO:0006694,GO:0006700,GO:0006744,GO:0008203,GO:0015039,GO:0016125,GO:0016491,GO:0055114" ferredoxin-NADP+ reductase activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|generation of precursor metabolites and energy|steroid biosynthetic process|C21-steroid hormone biosynthetic process|ubiquinone biosynthetic process|cholesterol metabolic process|NADPH-adrenodoxin reductase activity|sterol metabolic process|oxidoreductase activity|oxidation-reduction process FECH 1027.399762 1083.070852 971.7286715 0.897197695 -0.156502181 0.524888754 1 7.335215833 6.471012292 2235 ferrochelatase "GO:0004325,GO:0005515,GO:0005739,GO:0005743,GO:0005759,GO:0006091,GO:0006783,GO:0008198,GO:0009416,GO:0010288,GO:0017085,GO:0042493,GO:0045471,GO:0046501,GO:0046685,GO:0051537,GO:0051597,GO:0070541,GO:0071549" "ferrochelatase activity|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|generation of precursor metabolites and energy|heme biosynthetic process|ferrous iron binding|response to light stimulus|response to lead ion|response to insecticide|response to drug|response to ethanol|protoporphyrinogen IX metabolic process|response to arsenic-containing substance|2 iron, 2 sulfur cluster binding|response to methylmercury|response to platinum ion|cellular response to dexamethasone stimulus" hsa00860 Porphyrin and chlorophyll metabolism FEM1A 293.4973233 337.094098 249.9005486 0.741337656 -0.4317973 0.172821795 1 1.885753926 1.374587087 55527 fem-1 homolog A "GO:0000151,GO:0005515,GO:0005829,GO:0006511,GO:0016567,GO:0031867,GO:0043687,GO:0050728,GO:0051438" ubiquitin ligase complex|protein binding|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|EP4 subtype prostaglandin E2 receptor binding|post-translational protein modification|negative regulation of inflammatory response|regulation of ubiquitin-protein transferase activity FEM1B 1286.975422 1223.526726 1350.424118 1.103714442 0.14236696 0.555843606 1 9.098143043 9.873716757 10116 fem-1 homolog B "GO:0005123,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0016567,GO:0043687,GO:0051438,GO:0060442,GO:0060743,GO:1902041,GO:2000001" death receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|apoptotic process|protein ubiquitination|post-translational protein modification|regulation of ubiquitin-protein transferase activity|branching involved in prostate gland morphogenesis|epithelial cell maturation involved in prostate gland development|regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of DNA damage checkpoint FEM1C 647.0870155 624.2483296 669.9257013 1.073171797 0.101881045 0.698732842 1 5.433858429 5.733881966 56929 fem-1 homolog C "GO:0000151,GO:0005515,GO:0005654,GO:0005829,GO:0006511,GO:0016567,GO:0043687" ubiquitin ligase complex|protein binding|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|post-translational protein modification FEN1 2728.622726 2432.487658 3024.757794 1.243483306 0.314387139 0.183830132 1 64.39354939 78.73240209 2237 flap structure-specific endonuclease 1 "GO:0000287,GO:0000724,GO:0000781,GO:0003677,GO:0003684,GO:0003690,GO:0004519,GO:0004523,GO:0004527,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005739,GO:0006260,GO:0006281,GO:0006284,GO:0006302,GO:0007613,GO:0008309,GO:0008409,GO:0009650,GO:0016020,GO:0017108,GO:0030145,GO:0032201,GO:0032991,GO:0043137,GO:0045876,GO:0048256,GO:0090305,GO:0090502" "magnesium ion binding|double-strand break repair via homologous recombination|chromosome, telomeric region|DNA binding|damaged DNA binding|double-stranded DNA binding|endonuclease activity|RNA-DNA hybrid ribonuclease activity|exonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|mitochondrion|DNA replication|DNA repair|base-excision repair|double-strand break repair|memory|double-stranded DNA exodeoxyribonuclease activity|5'-3' exonuclease activity|UV protection|membrane|5'-flap endonuclease activity|manganese ion binding|telomere maintenance via semi-conservative replication|protein-containing complex|DNA replication, removal of RNA primer|positive regulation of sister chromatid cohesion|flap endonuclease activity|nucleic acid phosphodiester bond hydrolysis|RNA phosphodiester bond hydrolysis, endonucleolytic" "hsa03030,hsa03410,hsa03450" DNA replication|Base excision repair|Non-homologous end-joining FER 887.0917281 932.2108388 841.9726175 0.903199772 -0.146882972 0.556814065 1 3.044512523 2.703788788 2241 FER tyrosine kinase "GO:0000226,GO:0000785,GO:0001932,GO:0004713,GO:0004715,GO:0005102,GO:0005154,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005938,GO:0006468,GO:0006935,GO:0007155,GO:0007169,GO:0007260,GO:0008157,GO:0008283,GO:0008284,GO:0008289,GO:0010591,GO:0010762,GO:0015629,GO:0015630,GO:0018108,GO:0019221,GO:0030027,GO:0030054,GO:0030154,GO:0030335,GO:0030838,GO:0031234,GO:0031532,GO:0032496,GO:0032869,GO:0033007,GO:0034446,GO:0034614,GO:0035426,GO:0035556,GO:0036006,GO:0036119,GO:0038028,GO:0038083,GO:0038095,GO:0038109,GO:0042058,GO:0042127,GO:0043304,GO:0044331,GO:0045087,GO:0046777,GO:0048008,GO:0050904,GO:0051092,GO:0070102" microtubule cytoskeleton organization|chromatin|regulation of protein phosphorylation|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|epidermal growth factor receptor binding|protein binding|ATP binding|nucleus|cytoplasm|cytosol|cell cortex|protein phosphorylation|chemotaxis|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|tyrosine phosphorylation of STAT protein|protein phosphatase 1 binding|cell population proliferation|positive regulation of cell population proliferation|lipid binding|regulation of lamellipodium assembly|regulation of fibroblast migration|actin cytoskeleton|microtubule cytoskeleton|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|lamellipodium|cell junction|cell differentiation|positive regulation of cell migration|positive regulation of actin filament polymerization|extrinsic component of cytoplasmic side of plasma membrane|actin cytoskeleton reorganization|response to lipopolysaccharide|cellular response to insulin stimulus|negative regulation of mast cell activation involved in immune response|substrate adhesion-dependent cell spreading|cellular response to reactive oxygen species|extracellular matrix-cell signaling|intracellular signal transduction|cellular response to macrophage colony-stimulating factor stimulus|response to platelet-derived growth factor|insulin receptor signaling pathway via phosphatidylinositol 3-kinase|peptidyl-tyrosine autophosphorylation|Fc-epsilon receptor signaling pathway|Kit signaling pathway|regulation of epidermal growth factor receptor signaling pathway|regulation of cell population proliferation|regulation of mast cell degranulation|cell-cell adhesion mediated by cadherin|innate immune response|protein autophosphorylation|platelet-derived growth factor receptor signaling pathway|diapedesis|positive regulation of NF-kappaB transcription factor activity|interleukin-6-mediated signaling pathway hsa04520 Adherens junction FERMT1 471.9647458 404.7210003 539.2084913 1.332296794 0.413915506 0.135305332 1 4.658015084 6.102011925 55612 FERM domain containing kindlin 1 "GO:0001954,GO:0005178,GO:0005737,GO:0005829,GO:0005856,GO:0005925,GO:0007155,GO:0007160,GO:0007229,GO:0010629,GO:0030054,GO:0030055,GO:0030511,GO:0032587,GO:0033625,GO:0033630,GO:0042308,GO:0043616,GO:0051015,GO:0051546,GO:0051886,GO:0071636,GO:0071711,GO:0071944,GO:0090090,GO:0090162,GO:1903691,GO:2000647" "positive regulation of cell-matrix adhesion|integrin binding|cytoplasm|cytosol|cytoskeleton|focal adhesion|cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|negative regulation of gene expression|cell junction|cell-substrate junction|positive regulation of transforming growth factor beta receptor signaling pathway|ruffle membrane|positive regulation of integrin activation|positive regulation of cell adhesion mediated by integrin|negative regulation of protein import into nucleus|keratinocyte proliferation|actin filament binding|keratinocyte migration|negative regulation of timing of anagen|positive regulation of transforming growth factor beta production|basement membrane organization|cell periphery|negative regulation of canonical Wnt signaling pathway|establishment of epithelial cell polarity|positive regulation of wound healing, spreading of epidermal cells|negative regulation of stem cell proliferation" FERMT2 2271.871086 2338.850408 2204.891763 0.942724578 -0.085091754 0.72007605 1 34.35732113 31.84749678 10979 FERM domain containing kindlin 2 "GO:0001725,GO:0003779,GO:0005178,GO:0005515,GO:0005547,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0005925,GO:0005938,GO:0007155,GO:0007160,GO:0007179,GO:0007229,GO:0008360,GO:0009986,GO:0010718,GO:0016055,GO:0019901,GO:0022604,GO:0030054,GO:0030055,GO:0030335,GO:0031234,GO:0031258,GO:0031674,GO:0033622,GO:0033625,GO:0034329,GO:0034334,GO:0034446,GO:0034713,GO:0035505,GO:0043116,GO:0043547,GO:0045599,GO:0045669,GO:0046332,GO:0048041,GO:0051015,GO:0051496,GO:0051894,GO:0051897,GO:0060173,GO:0060548,GO:0070374,GO:0072657,GO:1900026,GO:1900182,GO:1902414,GO:1902462,GO:1903691" "stress fiber|actin binding|integrin binding|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|adherens junction|focal adhesion|cell cortex|cell adhesion|cell-matrix adhesion|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|regulation of cell shape|cell surface|positive regulation of epithelial to mesenchymal transition|Wnt signaling pathway|protein kinase binding|regulation of cell morphogenesis|cell junction|cell-substrate junction|positive regulation of cell migration|extrinsic component of cytoplasmic side of plasma membrane|lamellipodium membrane|I band|integrin activation|positive regulation of integrin activation|cell junction assembly|adherens junction maintenance|substrate adhesion-dependent cell spreading|type I transforming growth factor beta receptor binding|positive regulation of myosin light chain kinase activity|negative regulation of vascular permeability|positive regulation of GTPase activity|negative regulation of fat cell differentiation|positive regulation of osteoblast differentiation|SMAD binding|focal adhesion assembly|actin filament binding|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|limb development|negative regulation of cell death|positive regulation of ERK1 and ERK2 cascade|protein localization to membrane|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of protein localization to nucleus|protein localization to cell junction|positive regulation of mesenchymal stem cell proliferation|positive regulation of wound healing, spreading of epidermal cells" FERMT3 6.604174384 9.363724944 3.844623824 0.41058701 -1.284240111 0.3924594 1 0.171963108 0.069424325 83706 FERM domain containing kindlin 3 "GO:0002102,GO:0002576,GO:0005178,GO:0005576,GO:0007159,GO:0007160,GO:0007229,GO:0016020,GO:0030055,GO:0030335,GO:0031093,GO:0033622,GO:0033632,GO:0034446,GO:0042995,GO:0070062,GO:0070527" podosome|platelet degranulation|integrin binding|extracellular region|leukocyte cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|membrane|cell-substrate junction|positive regulation of cell migration|platelet alpha granule lumen|integrin activation|regulation of cell-cell adhesion mediated by integrin|substrate adhesion-dependent cell spreading|cell projection|extracellular exosome|platelet aggregation hsa04611 Platelet activation FES 11.96979007 11.44455271 12.49502743 1.091788185 0.12669299 0.995605371 1 0.216586789 0.232509944 2242 "FES proto-oncogene, tyrosine kinase" "GO:0001578,GO:0004713,GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005737,GO:0005794,GO:0005829,GO:0005925,GO:0006935,GO:0007098,GO:0007155,GO:0007169,GO:0008017,GO:0008360,GO:0010976,GO:0015630,GO:0018108,GO:0030154,GO:0030155,GO:0031116,GO:0031234,GO:0031410,GO:0034987,GO:0035091,GO:0038083,GO:0042127,GO:0043304,GO:0045087,GO:0045595,GO:0045639,GO:0045657,GO:0046777,GO:0060627,GO:0071305,GO:2000145,GO:2000251" microtubule bundle formation|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|protein binding|ATP binding|cytoplasm|Golgi apparatus|cytosol|focal adhesion|chemotaxis|centrosome cycle|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|microtubule binding|regulation of cell shape|positive regulation of neuron projection development|microtubule cytoskeleton|peptidyl-tyrosine phosphorylation|cell differentiation|regulation of cell adhesion|positive regulation of microtubule polymerization|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic vesicle|immunoglobulin receptor binding|phosphatidylinositol binding|peptidyl-tyrosine autophosphorylation|regulation of cell population proliferation|regulation of mast cell degranulation|innate immune response|regulation of cell differentiation|positive regulation of myeloid cell differentiation|positive regulation of monocyte differentiation|protein autophosphorylation|regulation of vesicle-mediated transport|cellular response to vitamin D|regulation of cell motility|positive regulation of actin cytoskeleton reorganization hsa04360 Axon guidance FEZ1 2502.512688 2527.165321 2477.860055 0.980489893 -0.028425336 0.905953606 1 21.16938761 20.40904083 9638 fasciculation and elongation protein zeta 1 "GO:0005080,GO:0005515,GO:0005737,GO:0005739,GO:0005794,GO:0005813,GO:0005874,GO:0005886,GO:0007155,GO:0007399,GO:0007411,GO:0010976,GO:0021766,GO:0030010,GO:0030424,GO:0030425,GO:0030426,GO:0043015,GO:0043025,GO:0045666,GO:0047485,GO:0051654,GO:0061881,GO:0070584,GO:0071363,GO:1902902" protein kinase C binding|protein binding|cytoplasm|mitochondrion|Golgi apparatus|centrosome|microtubule|plasma membrane|cell adhesion|nervous system development|axon guidance|positive regulation of neuron projection development|hippocampus development|establishment of cell polarity|axon|dendrite|growth cone|gamma-tubulin binding|neuronal cell body|positive regulation of neuron differentiation|protein N-terminus binding|establishment of mitochondrion localization|positive regulation of anterograde axonal transport of mitochondrion|mitochondrion morphogenesis|cellular response to growth factor stimulus|negative regulation of autophagosome assembly FEZ2 1714.657797 1601.196965 1828.118628 1.141720018 0.191208905 0.421131282 1 38.35410196 43.05688556 9637 fasciculation and elongation protein zeta 2 "GO:0005515,GO:0005737,GO:0007165,GO:0007399,GO:0007411,GO:0030424,GO:1902902" protein binding|cytoplasm|signal transduction|nervous system development|axon guidance|axon|negative regulation of autophagosome assembly FEZF1 61.16676697 66.58648849 55.74704545 0.837212574 -0.256334115 0.66393117 1 0.870766604 0.716817642 389549 FEZ family zinc finger 1 "GO:0000122,GO:0000978,GO:0001227,GO:0001764,GO:0003700,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0007411,GO:0008285,GO:0021772,GO:0021797,GO:0043697,GO:0045666,GO:0045893,GO:0046872,GO:0050767" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|neuron migration|DNA-binding transcription factor activity|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|axon guidance|negative regulation of cell population proliferation|olfactory bulb development|forebrain anterior/posterior pattern specification|cell dedifferentiation|positive regulation of neuron differentiation|positive regulation of transcription, DNA-templated|metal ion binding|regulation of neurogenesis" zf-C2H2 FFAR4 4.483717655 4.161655531 4.80577978 1.154775965 0.207612985 1 1 0.050940346 0.057840335 338557 free fatty acid receptor 4 "GO:0001818,GO:0004930,GO:0005504,GO:0005765,GO:0005886,GO:0005887,GO:0005929,GO:0006954,GO:0007186,GO:0007200,GO:0007204,GO:0008527,GO:0010008,GO:0010827,GO:0030139,GO:0032691,GO:0036321,GO:0043066,GO:0043950,GO:0045669,GO:0046879,GO:0050728,GO:0050872,GO:0050873,GO:0050912,GO:0060170,GO:0070094,GO:0070374,GO:0090275,GO:0090336,GO:0120162" negative regulation of cytokine production|G protein-coupled receptor activity|fatty acid binding|lysosomal membrane|plasma membrane|integral component of plasma membrane|cilium|inflammatory response|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|taste receptor activity|endosome membrane|regulation of glucose transmembrane transport|endocytic vesicle|negative regulation of interleukin-1 beta production|ghrelin secretion|negative regulation of apoptotic process|positive regulation of cAMP-mediated signaling|positive regulation of osteoblast differentiation|hormone secretion|negative regulation of inflammatory response|white fat cell differentiation|brown fat cell differentiation|detection of chemical stimulus involved in sensory perception of taste|ciliary membrane|positive regulation of glucagon secretion|positive regulation of ERK1 and ERK2 cascade|negative regulation of somatostatin secretion|positive regulation of brown fat cell differentiation|positive regulation of cold-induced thermogenesis FGD1 884.7680962 934.2916666 835.2445258 0.893986916 -0.161674378 0.517507105 1 11.48087246 10.09199981 2245 "FYVE, RhoGEF and PH domain containing 1" "GO:0001726,GO:0005085,GO:0005737,GO:0005794,GO:0005829,GO:0005856,GO:0007010,GO:0007165,GO:0007186,GO:0007275,GO:0008360,GO:0009887,GO:0030027,GO:0030036,GO:0031267,GO:0043065,GO:0043087,GO:0046847,GO:0046872,GO:0051056" ruffle|guanyl-nucleotide exchange factor activity|cytoplasm|Golgi apparatus|cytosol|cytoskeleton|cytoskeleton organization|signal transduction|G protein-coupled receptor signaling pathway|multicellular organism development|regulation of cell shape|animal organ morphogenesis|lamellipodium|actin cytoskeleton organization|small GTPase binding|positive regulation of apoptotic process|regulation of GTPase activity|filopodium assembly|metal ion binding|regulation of small GTPase mediated signal transduction hsa04810 Regulation of actin cytoskeleton FGD4 381.8192612 397.4381032 366.2004192 0.921402393 -0.11809675 0.693028268 1 2.133213427 1.932657173 121512 "FYVE, RhoGEF and PH domain containing 4" "GO:0001726,GO:0003779,GO:0005085,GO:0005737,GO:0005794,GO:0005829,GO:0005856,GO:0007010,GO:0007186,GO:0008360,GO:0030027,GO:0030036,GO:0030175,GO:0031267,GO:0043065,GO:0043087,GO:0046847,GO:0046872,GO:0051056" ruffle|actin binding|guanyl-nucleotide exchange factor activity|cytoplasm|Golgi apparatus|cytosol|cytoskeleton|cytoskeleton organization|G protein-coupled receptor signaling pathway|regulation of cell shape|lamellipodium|actin cytoskeleton organization|filopodium|small GTPase binding|positive regulation of apoptotic process|regulation of GTPase activity|filopodium assembly|metal ion binding|regulation of small GTPase mediated signal transduction FGD6 592.3508158 600.3188103 584.3828212 0.973454123 -0.038815105 0.889309392 1 3.448273767 3.30056588 55785 "FYVE, RhoGEF and PH domain containing 6" "GO:0001726,GO:0005085,GO:0005737,GO:0005794,GO:0005856,GO:0007010,GO:0008360,GO:0030027,GO:0030036,GO:0031267,GO:0043087,GO:0046847,GO:0046872" ruffle|guanyl-nucleotide exchange factor activity|cytoplasm|Golgi apparatus|cytoskeleton|cytoskeleton organization|regulation of cell shape|lamellipodium|actin cytoskeleton organization|small GTPase binding|regulation of GTPase activity|filopodium assembly|metal ion binding FGF1 129.1610052 85.31393838 173.0080721 2.027899255 1.019985982 0.017732075 0.773499658 0.943245927 1.880799467 2246 fibroblast growth factor 1 "GO:0000165,GO:0000187,GO:0001525,GO:0001759,GO:0001934,GO:0005104,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005938,GO:0007165,GO:0007275,GO:0008083,GO:0008201,GO:0008284,GO:0008543,GO:0009653,GO:0009887,GO:0010595,GO:0010628,GO:0030154,GO:0030324,GO:0030334,GO:0030335,GO:0030544,GO:0031012,GO:0032148,GO:0034605,GO:0042060,GO:0043406,GO:0044548,GO:0045542,GO:0045766,GO:0045944,GO:0050679,GO:0051781,GO:0051897,GO:0060681,GO:0072163,GO:1901509,GO:1902533,GO:1903672,GO:2000347,GO:2000544" MAPK cascade|activation of MAPK activity|angiogenesis|organ induction|positive regulation of protein phosphorylation|fibroblast growth factor receptor binding|integrin binding|protein binding|extracellular region|extracellular space|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|cell cortex|signal transduction|multicellular organism development|growth factor activity|heparin binding|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|anatomical structure morphogenesis|animal organ morphogenesis|positive regulation of endothelial cell migration|positive regulation of gene expression|cell differentiation|lung development|regulation of cell migration|positive regulation of cell migration|Hsp70 protein binding|extracellular matrix|activation of protein kinase B activity|cellular response to heat|wound healing|positive regulation of MAP kinase activity|S100 protein binding|positive regulation of cholesterol biosynthetic process|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|positive regulation of epithelial cell proliferation|positive regulation of cell division|positive regulation of protein kinase B signaling|branch elongation involved in ureteric bud branching|mesonephric epithelium development|regulation of endothelial tube morphogenesis|positive regulation of intracellular signal transduction|positive regulation of sprouting angiogenesis|positive regulation of hepatocyte proliferation|regulation of endothelial cell chemotaxis to fibroblast growth factor "hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04390,hsa04810,hsa05200,hsa05218,hsa05224,hsa05226" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Hippo signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Melanoma|Breast cancer|Gastric cancer FGF11 44.23771168 38.49531366 49.98010971 1.298342706 0.376671243 0.565990183 1 0.776133033 0.990824391 2256 fibroblast growth factor 11 "GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0007165,GO:0007267,GO:0007399,GO:0008083,GO:0017080,GO:1905150" protein binding|extracellular region|nucleus|cytoplasm|signal transduction|cell-cell signaling|nervous system development|growth factor activity|sodium channel regulator activity|regulation of voltage-gated sodium channel activity FGF13 139.1933921 134.2133909 144.1733934 1.0742102 0.103276325 0.819826329 1 0.346527431 0.366014313 2258 fibroblast growth factor 13 "GO:0000165,GO:0001764,GO:0005515,GO:0005576,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005874,GO:0005886,GO:0006814,GO:0007026,GO:0007165,GO:0007267,GO:0007399,GO:0007612,GO:0007613,GO:0008017,GO:0008083,GO:0014704,GO:0016328,GO:0017080,GO:0021766,GO:0021795,GO:0030175,GO:0030295,GO:0030424,GO:0030425,GO:0030426,GO:0032147,GO:0043005,GO:0044325,GO:0045200,GO:0046785,GO:0048487,GO:0048671,GO:0072659,GO:0098909,GO:1904862,GO:1905150" MAPK cascade|neuron migration|protein binding|extracellular region|nucleus|nucleolus|cytoplasm|cytosol|microtubule|plasma membrane|sodium ion transport|negative regulation of microtubule depolymerization|signal transduction|cell-cell signaling|nervous system development|learning|memory|microtubule binding|growth factor activity|intercalated disc|lateral plasma membrane|sodium channel regulator activity|hippocampus development|cerebral cortex cell migration|filopodium|protein kinase activator activity|axon|dendrite|growth cone|activation of protein kinase activity|neuron projection|ion channel binding|establishment of neuroblast polarity|microtubule polymerization|beta-tubulin binding|negative regulation of collateral sprouting|protein localization to plasma membrane|regulation of cardiac muscle cell action potential involved in regulation of contraction|inhibitory synapse assembly|regulation of voltage-gated sodium channel activity FGF17 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.036739067 0.022248245 8822 fibroblast growth factor 17 "GO:0000165,GO:0001934,GO:0005104,GO:0005105,GO:0005111,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0007165,GO:0007267,GO:0007399,GO:0008083,GO:0008284,GO:0008543,GO:0009887,GO:0010628,GO:0030154,GO:0030334,GO:0051897" MAPK cascade|positive regulation of protein phosphorylation|fibroblast growth factor receptor binding|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding|protein binding|extracellular region|extracellular space|cytoplasm|signal transduction|cell-cell signaling|nervous system development|growth factor activity|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|animal organ morphogenesis|positive regulation of gene expression|cell differentiation|regulation of cell migration|positive regulation of protein kinase B signaling "hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04810,hsa05200,hsa05218,hsa05224,hsa05226" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Melanoma|Breast cancer|Gastric cancer FGF2 2436.657799 2665.540367 2207.775231 0.82826554 -0.271834729 0.250160299 1 20.99704655 17.10011308 2247 fibroblast growth factor 2 "GO:0000165,GO:0000187,GO:0001658,GO:0001934,GO:0001938,GO:0002042,GO:0005104,GO:0005125,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0006661,GO:0006935,GO:0007165,GO:0007265,GO:0007399,GO:0008083,GO:0008201,GO:0008284,GO:0008543,GO:0009887,GO:0010595,GO:0010628,GO:0010629,GO:0010764,GO:0010863,GO:0014068,GO:0014843,GO:0019221,GO:0019956,GO:0030154,GO:0030198,GO:0030214,GO:0030324,GO:0030334,GO:0030374,GO:0032958,GO:0035019,GO:0038001,GO:0040037,GO:0042056,GO:0042060,GO:0042660,GO:0042802,GO:0043406,GO:0043410,GO:0043536,GO:0043537,GO:0043552,GO:0045765,GO:0045766,GO:0045893,GO:0045944,GO:0048598,GO:0050679,GO:0050918,GO:0051209,GO:0051781,GO:0051897,GO:0060045,GO:0060548,GO:0060591,GO:0061045,GO:0070374,GO:0072089,GO:0090049,GO:0090050,GO:0090722,GO:1902748,GO:1902895,GO:1903587,GO:1903672,GO:1904707,GO:1905278,GO:1905564,GO:2000544,GO:2000546,GO:2000573,GO:2001028" "MAPK cascade|activation of MAPK activity|branching involved in ureteric bud morphogenesis|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|cell migration involved in sprouting angiogenesis|fibroblast growth factor receptor binding|cytokine activity|integrin binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|phosphatidylinositol biosynthetic process|chemotaxis|signal transduction|Ras protein signal transduction|nervous system development|growth factor activity|heparin binding|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|animal organ morphogenesis|positive regulation of endothelial cell migration|positive regulation of gene expression|negative regulation of gene expression|negative regulation of fibroblast migration|positive regulation of phospholipase C activity|positive regulation of phosphatidylinositol 3-kinase signaling|growth factor dependent regulation of skeletal muscle satellite cell proliferation|cytokine-mediated signaling pathway|chemokine binding|cell differentiation|extracellular matrix organization|hyaluronan catabolic process|lung development|regulation of cell migration|nuclear receptor coactivator activity|inositol phosphate biosynthetic process|somatic stem cell population maintenance|paracrine signaling|negative regulation of fibroblast growth factor receptor signaling pathway|chemoattractant activity|wound healing|positive regulation of cell fate specification|identical protein binding|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|positive regulation of blood vessel endothelial cell migration|negative regulation of blood vessel endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase activity|regulation of angiogenesis|positive regulation of angiogenesis|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|embryonic morphogenesis|positive regulation of epithelial cell proliferation|positive chemotaxis|release of sequestered calcium ion into cytosol|positive regulation of cell division|positive regulation of protein kinase B signaling|positive regulation of cardiac muscle cell proliferation|negative regulation of cell death|chondroblast differentiation|negative regulation of wound healing|positive regulation of ERK1 and ERK2 cascade|stem cell proliferation|regulation of cell migration involved in sprouting angiogenesis|positive regulation of cell migration involved in sprouting angiogenesis|receptor-receptor interaction|positive regulation of lens fiber cell differentiation|positive regulation of pri-miRNA transcription by RNA polymerase II|regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|positive regulation of sprouting angiogenesis|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of epithelial tube formation|positive regulation of vascular endothelial cell proliferation|regulation of endothelial cell chemotaxis to fibroblast growth factor|positive regulation of endothelial cell chemotaxis to fibroblast growth factor|positive regulation of DNA biosynthetic process|positive regulation of endothelial cell chemotaxis" "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04550,hsa04810,hsa05167,hsa05200,hsa05205,hsa05218,hsa05224,hsa05226" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Proteoglycans in cancer|Melanoma|Breast cancer|Gastric cancer FGF20 20.37738947 17.687036 23.06774294 1.30421756 0.38318455 0.689777351 1 0.513002502 0.657870944 26281 fibroblast growth factor 20 "GO:0000165,GO:0001934,GO:0005102,GO:0005104,GO:0005576,GO:0005615,GO:0005737,GO:0007165,GO:0007267,GO:0008083,GO:0008284,GO:0008543,GO:0009887,GO:0010628,GO:0014059,GO:0030154,GO:0030334,GO:0043395,GO:0043524,GO:0051897,GO:0060043,GO:0060113,GO:0070374,GO:0090722,GO:1904340" MAPK cascade|positive regulation of protein phosphorylation|signaling receptor binding|fibroblast growth factor receptor binding|extracellular region|extracellular space|cytoplasm|signal transduction|cell-cell signaling|growth factor activity|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|animal organ morphogenesis|positive regulation of gene expression|regulation of dopamine secretion|cell differentiation|regulation of cell migration|heparan sulfate proteoglycan binding|negative regulation of neuron apoptotic process|positive regulation of protein kinase B signaling|regulation of cardiac muscle cell proliferation|inner ear receptor cell differentiation|positive regulation of ERK1 and ERK2 cascade|receptor-receptor interaction|positive regulation of dopaminergic neuron differentiation "hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04810,hsa05200,hsa05218,hsa05224,hsa05226" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Melanoma|Breast cancer|Gastric cancer FGF5 1951.680891 1755.17822 2148.183562 1.223911929 0.291499748 0.218233867 1 16.46232614 19.81128053 2250 fibroblast growth factor 5 "GO:0000165,GO:0001934,GO:0005104,GO:0005576,GO:0005615,GO:0005737,GO:0007267,GO:0007399,GO:0008083,GO:0008284,GO:0008543,GO:0009887,GO:0010001,GO:0010628,GO:0023019,GO:0030154,GO:0030334,GO:0051781,GO:0051897" MAPK cascade|positive regulation of protein phosphorylation|fibroblast growth factor receptor binding|extracellular region|extracellular space|cytoplasm|cell-cell signaling|nervous system development|growth factor activity|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|animal organ morphogenesis|glial cell differentiation|positive regulation of gene expression|signal transduction involved in regulation of gene expression|cell differentiation|regulation of cell migration|positive regulation of cell division|positive regulation of protein kinase B signaling "hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04810,hsa05200,hsa05218,hsa05224,hsa05226" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Melanoma|Breast cancer|Gastric cancer FGFBP1 210.5019864 176.87036 244.1336128 1.380296918 0.464978641 0.192818852 1 6.986858654 9.482561199 9982 fibroblast growth factor binding protein 1 "GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0007165,GO:0007267,GO:0008201,GO:0008285,GO:0008543,GO:0009986,GO:0017134,GO:0019838,GO:0045743,GO:0090050,GO:1903589" protein binding|extracellular region|extracellular space|plasma membrane|signal transduction|cell-cell signaling|heparin binding|negative regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|cell surface|fibroblast growth factor binding|growth factor binding|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis FGFBP3 44.79251717 53.06110801 36.52392633 0.688337046 -0.538812938 0.396182853 1 1.1091946 0.7507236 143282 fibroblast growth factor binding protein 3 "GO:0005576,GO:0007267,GO:0008201,GO:0017134,GO:0019838,GO:0043117,GO:0045743,GO:0062023" extracellular region|cell-cell signaling|heparin binding|fibroblast growth factor binding|growth factor binding|positive regulation of vascular permeability|positive regulation of fibroblast growth factor receptor signaling pathway|collagen-containing extracellular matrix FGFR1 2165.124867 2084.989421 2245.260313 1.076868924 0.106842656 0.652422347 1 15.07342906 15.960485 2260 fibroblast growth factor receptor 1 "GO:0000165,GO:0001501,GO:0001764,GO:0001837,GO:0004713,GO:0004714,GO:0005007,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005829,GO:0005886,GO:0005887,GO:0006468,GO:0007169,GO:0007275,GO:0008201,GO:0008284,GO:0008543,GO:0010518,GO:0010863,GO:0014068,GO:0016021,GO:0016477,GO:0017134,GO:0018108,GO:0031410,GO:0033674,GO:0042802,GO:0042803,GO:0043009,GO:0043235,GO:0043406,GO:0043410,GO:0043536,GO:0045595,GO:0045597,GO:0045666,GO:0046777,GO:0048015,GO:0048705,GO:0051897,GO:0090722,GO:1905564,GO:2000546,GO:2001239" MAPK cascade|skeletal system development|neuron migration|epithelial to mesenchymal transition|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|fibroblast growth factor-activated receptor activity|protein binding|ATP binding|extracellular region|nucleus|cytosol|plasma membrane|integral component of plasma membrane|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|heparin binding|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|positive regulation of phospholipase activity|positive regulation of phospholipase C activity|positive regulation of phosphatidylinositol 3-kinase signaling|integral component of membrane|cell migration|fibroblast growth factor binding|peptidyl-tyrosine phosphorylation|cytoplasmic vesicle|positive regulation of kinase activity|identical protein binding|protein homodimerization activity|chordate embryonic development|receptor complex|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|positive regulation of blood vessel endothelial cell migration|regulation of cell differentiation|positive regulation of cell differentiation|positive regulation of neuron differentiation|protein autophosphorylation|phosphatidylinositol-mediated signaling|skeletal system morphogenesis|positive regulation of protein kinase B signaling|receptor-receptor interaction|positive regulation of vascular endothelial cell proliferation|positive regulation of endothelial cell chemotaxis to fibroblast growth factor|regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04520,hsa04550,hsa04714,hsa04810,hsa04928,hsa05200,hsa05205,hsa05215,hsa05218,hsa05224,hsa05230" "MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Adherens junction|Signaling pathways regulating pluripotency of stem cells|Thermogenesis|Regulation of actin cytoskeleton|Parathyroid hormone synthesis, secretion and action|Pathways in cancer|Proteoglycans in cancer|Prostate cancer|Melanoma|Breast cancer|Central carbon metabolism in cancer" FGFR1OP2 864.6391557 796.9570341 932.3212773 1.169851369 0.226325245 0.365034967 1 13.92213819 16.01429433 26127 FGFR1 oncogene partner 2 "GO:0005515,GO:0005829,GO:0009611,GO:0042060,GO:0042802" protein binding|cytosol|response to wounding|wound healing|identical protein binding FGFR3 25.42094303 23.9295193 26.91236677 1.124651374 0.169477856 0.876198655 1 0.28614709 0.316430568 2261 fibroblast growth factor receptor 3 "GO:0000165,GO:0001501,GO:0001958,GO:0002062,GO:0003416,GO:0004713,GO:0004714,GO:0005007,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0005925,GO:0007169,GO:0007267,GO:0007275,GO:0008284,GO:0008543,GO:0009986,GO:0010518,GO:0017134,GO:0018108,GO:0030133,GO:0030282,GO:0033674,GO:0035988,GO:0042531,GO:0042802,GO:0043235,GO:0043410,GO:0043552,GO:0046777,GO:0048640,GO:0051897,GO:0060349,GO:0070374,GO:0070977,GO:1902178" MAPK cascade|skeletal system development|endochondral ossification|chondrocyte differentiation|endochondral bone growth|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|fibroblast growth factor-activated receptor activity|protein binding|ATP binding|extracellular region|nucleus|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|focal adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|cell-cell signaling|multicellular organism development|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|cell surface|positive regulation of phospholipase activity|fibroblast growth factor binding|peptidyl-tyrosine phosphorylation|transport vesicle|bone mineralization|positive regulation of kinase activity|chondrocyte proliferation|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|receptor complex|positive regulation of MAPK cascade|positive regulation of phosphatidylinositol 3-kinase activity|protein autophosphorylation|negative regulation of developmental growth|positive regulation of protein kinase B signaling|bone morphogenesis|positive regulation of ERK1 and ERK2 cascade|bone maturation|fibroblast growth factor receptor apoptotic signaling pathway "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04144,hsa04151,hsa04550,hsa04810,hsa05200,hsa05206,hsa05219,hsa05230" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Endocytosis|PI3K-Akt signaling pathway|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Pathways in cancer|MicroRNAs in cancer|Bladder cancer|Central carbon metabolism in cancer FGFR4 281.7011403 292.356301 271.0459796 0.92710839 -0.109190078 0.743157426 1 5.023347861 4.579256216 2264 fibroblast growth factor receptor 4 "GO:0000165,GO:0004714,GO:0005007,GO:0005515,GO:0005524,GO:0005576,GO:0005768,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0005911,GO:0007169,GO:0007275,GO:0008201,GO:0008284,GO:0008543,GO:0010628,GO:0010715,GO:0016477,GO:0017134,GO:0018108,GO:0019216,GO:0030133,GO:0033674,GO:0042593,GO:0042632,GO:0043085,GO:0043235,GO:0045862,GO:0046777,GO:0051897,GO:0055062,GO:0070374,GO:0070857,GO:1903412,GO:2000573" MAPK cascade|transmembrane receptor protein tyrosine kinase activity|fibroblast growth factor-activated receptor activity|protein binding|ATP binding|extracellular region|endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|cell-cell junction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|heparin binding|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|positive regulation of gene expression|regulation of extracellular matrix disassembly|cell migration|fibroblast growth factor binding|peptidyl-tyrosine phosphorylation|regulation of lipid metabolic process|transport vesicle|positive regulation of kinase activity|glucose homeostasis|cholesterol homeostasis|positive regulation of catalytic activity|receptor complex|positive regulation of proteolysis|protein autophosphorylation|positive regulation of protein kinase B signaling|phosphate ion homeostasis|positive regulation of ERK1 and ERK2 cascade|regulation of bile acid biosynthetic process|response to bile acid|positive regulation of DNA biosynthetic process "hsa04010,hsa04014,hsa04015,hsa04020,hsa04144,hsa04151,hsa04550,hsa04810,hsa05200" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Endocytosis|PI3K-Akt signaling pathway|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Pathways in cancer FGFRL1 945.2422779 831.2906922 1059.193864 1.274155808 0.349541706 0.157303131 1 9.714135405 12.17020432 53834 fibroblast growth factor receptor like 1 "GO:0005007,GO:0005794,GO:0005886,GO:0008201,GO:0008543,GO:0016021,GO:0017134,GO:0030133,GO:0042802,GO:0044291,GO:0098742" fibroblast growth factor-activated receptor activity|Golgi apparatus|plasma membrane|heparin binding|fibroblast growth factor receptor signaling pathway|integral component of membrane|fibroblast growth factor binding|transport vesicle|identical protein binding|cell-cell contact zone|cell-cell adhesion via plasma-membrane adhesion molecules FGGY 136.1564388 117.5667687 154.7461089 1.316240215 0.396422806 0.349029776 1 0.559158931 0.723671718 55277 FGGY carbohydrate kinase domain containing "GO:0005575,GO:0019150,GO:0019321,GO:0046835,GO:0070050" cellular_component|D-ribulokinase activity|pentose metabolic process|carbohydrate phosphorylation|neuron cellular homeostasis FH 1816.242189 1744.774081 1887.710298 1.081922478 0.113597131 0.633019807 1 40.10137207 42.66056026 2271 fumarate hydratase "GO:0004333,GO:0005515,GO:0005634,GO:0005694,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006099,GO:0006106,GO:0006108,GO:0006281,GO:0045239,GO:0048873,GO:0070062,GO:0120162" fumarate hydratase activity|protein binding|nucleus|chromosome|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|tricarboxylic acid cycle|fumarate metabolic process|malate metabolic process|DNA repair|tricarboxylic acid cycle enzyme complex|homeostasis of number of cells within a tissue|extracellular exosome|positive regulation of cold-induced thermogenesis "hsa00020,hsa00620,hsa04934,hsa05200,hsa05211" Citrate cycle (TCA cycle)|Pyruvate metabolism|Cushing syndrome|Pathways in cancer|Renal cell carcinoma FHAD1 20.61516325 23.9295193 17.30080721 0.722990169 -0.467952065 0.608529082 1 0.180530741 0.128337843 114827 forkhead associated phosphopeptide binding domain 1 FHDC1 40.47234579 40.57614142 40.36855015 0.994883908 -0.007399906 1 1 0.293782946 0.287389016 85462 FH2 domain containing 1 "GO:0003779,GO:0005794,GO:0005874,GO:0005881,GO:0005929,GO:0008017,GO:0043149,GO:0060271,GO:0090161" actin binding|Golgi apparatus|microtubule|cytoplasmic microtubule|cilium|microtubule binding|stress fiber assembly|cilium assembly|Golgi ribbon formation FHIP1A 426.8495522 456.7416945 396.9574098 0.869107013 -0.202394268 0.479278333 1 1.836054894 1.569025835 729830 FHF complex subunit HOOK interacting protein 1A FHIP1B 568.6741615 521.2473552 616.1009678 1.181974281 0.241198644 0.36548433 1 7.615114518 8.850252144 84067 FHF complex subunit HOOK interacting protein 1B FHIP2A 453.3756901 421.3676225 485.3837578 1.151924666 0.20404637 0.468747728 1 3.676249072 4.163898977 57700 FHF complex subunit HOOK interacting protein 2A FHIP2B 604.9049794 652.3395044 557.4704545 0.854571049 -0.226727653 0.38917681 1 8.547547361 7.182255824 64760 FHF complex subunit HOOK interacting protein 2B FHIT 6.886607545 4.161655531 9.61155956 2.309551929 1.207612985 0.417805055 1 0.036814173 0.083601479 2272 fragile histidine triad diadenosine triphosphatase "GO:0000166,GO:0001650,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006163,GO:0015964,GO:0031625,GO:0032435,GO:0042802,GO:0047710,GO:0072332" nucleotide binding|fibrillar center|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|plasma membrane|purine nucleotide metabolic process|diadenosine triphosphate catabolic process|ubiquitin protein ligase binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|identical protein binding|bis(5'-adenosyl)-triphosphatase activity|intrinsic apoptotic signaling pathway by p53 class mediator "hsa00230,hsa05222,hsa05223" Purine metabolism|Small cell lung cancer|Non-small cell lung cancer FHL1 7676.793288 7154.926271 8198.660305 1.145876281 0.196451286 0.424513484 1 97.9592778 110.3708744 2273 four and a half LIM domains 1 "GO:0003254,GO:0003674,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0007517,GO:0009887,GO:0010972,GO:0030154,GO:0030308,GO:0043268,GO:0044325,GO:0046872,GO:1901016,GO:2000134" regulation of membrane depolarization|molecular_function|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|focal adhesion|muscle organ development|animal organ morphogenesis|negative regulation of G2/M transition of mitotic cell cycle|cell differentiation|negative regulation of cell growth|positive regulation of potassium ion transport|ion channel binding|metal ion binding|regulation of potassium ion transmembrane transporter activity|negative regulation of G1/S transition of mitotic cell cycle hsa04630 JAK-STAT signaling pathway FHL2 4207.378329 3682.024731 4732.731927 1.285361255 0.36217389 0.129073595 1 35.72779865 45.15466675 2274 four and a half LIM domains 2 "GO:0000122,GO:0001649,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005925,GO:0008134,GO:0009725,GO:0019216,GO:0030018,GO:0031430,GO:0042802,GO:0043066,GO:0043425,GO:0046872,GO:0055014,GO:0055015,GO:0060347,GO:0070885" negative regulation of transcription by RNA polymerase II|osteoblast differentiation|transcription coregulator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|focal adhesion|transcription factor binding|response to hormone|regulation of lipid metabolic process|Z disc|M band|identical protein binding|negative regulation of apoptotic process|bHLH transcription factor binding|metal ion binding|atrial cardiac muscle cell development|ventricular cardiac muscle cell development|heart trabecula formation|negative regulation of calcineurin-NFAT signaling cascade hsa04380 Osteoclast differentiation FHL3 230.7799963 242.4164347 219.143558 0.903996292 -0.14561124 0.681072484 1 7.592323694 6.748582217 2275 four and a half LIM domains 3 "GO:0001725,GO:0003712,GO:0003779,GO:0005515,GO:0005634,GO:0005925,GO:0006355,GO:0007517,GO:0030018,GO:0030036,GO:0046872" "stress fiber|transcription coregulator activity|actin binding|protein binding|nucleus|focal adhesion|regulation of transcription, DNA-templated|muscle organ development|Z disc|actin cytoskeleton organization|metal ion binding" FHOD1 905.8732839 1034.171399 777.5751684 0.751882298 -0.411421259 0.097233567 1 12.79958879 9.462743238 29109 formin homology 2 domain containing 1 "GO:0001725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0007097,GO:0014704,GO:0016020,GO:0019904,GO:0030866,GO:0032059,GO:0042802,GO:0043621,GO:0045944,GO:0051015,GO:0051492,GO:0051496,GO:0051639,GO:0051660" stress fiber|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|nuclear migration|intercalated disc|membrane|protein domain specific binding|cortical actin cytoskeleton organization|bleb|identical protein binding|protein self-association|positive regulation of transcription by RNA polymerase II|actin filament binding|regulation of stress fiber assembly|positive regulation of stress fiber assembly|actin filament network formation|establishment of centrosome localization hsa05132 Salmonella infection FHOD3 917.1108597 874.9880753 959.2336441 1.096281962 0.132618905 0.594909273 1 6.012167557 6.480738872 80206 formin homology 2 domain containing 3 "GO:0005515,GO:0005737,GO:0005856,GO:0005865,GO:0030018,GO:0030837,GO:0030866,GO:0045214,GO:0051015,GO:0051639,GO:0055003" protein binding|cytoplasm|cytoskeleton|striated muscle thin filament|Z disc|negative regulation of actin filament polymerization|cortical actin cytoskeleton organization|sarcomere organization|actin filament binding|actin filament network formation|cardiac myofibril assembly FIBCD1 15.89367182 13.52538047 18.26196316 1.350199589 0.433172685 0.689082402 1 0.197760191 0.262547582 84929 fibrinogen C domain containing 1 "GO:0005102,GO:0005515,GO:0005615,GO:0007155,GO:0008061,GO:0016020,GO:0016021,GO:0046872,GO:0062023" signaling receptor binding|protein binding|extracellular space|cell adhesion|chitin binding|membrane|integral component of membrane|metal ion binding|collagen-containing extracellular matrix FIBP 1135.430427 1130.92989 1139.930964 1.007959002 0.01143696 0.966500978 1 38.22397067 37.88347816 9158 FGF1 intracellular binding protein "GO:0005634,GO:0005739,GO:0008543,GO:0012505,GO:0016020,GO:0016607,GO:0017134,GO:0070527" nucleus|mitochondrion|fibroblast growth factor receptor signaling pathway|endomembrane system|membrane|nuclear speck|fibroblast growth factor binding|platelet aggregation FICD 177.2974466 188.3149128 166.2799804 0.882988914 -0.179532769 0.64627247 1 3.087563989 2.680664092 11153 FIC domain protein adenylyltransferase "GO:0005515,GO:0005524,GO:0006986,GO:0018117,GO:0030176,GO:0030544,GO:0034260,GO:0034976,GO:0042802,GO:0042803,GO:0044602,GO:0044603,GO:0051087,GO:0070733,GO:1903894" protein binding|ATP binding|response to unfolded protein|protein adenylylation|integral component of endoplasmic reticulum membrane|Hsp70 protein binding|negative regulation of GTPase activity|response to endoplasmic reticulum stress|identical protein binding|protein homodimerization activity|protein deadenylylation|protein adenylylhydrolase activity|chaperone binding|protein adenylyltransferase activity|regulation of IRE1-mediated unfolded protein response FIG4 379.7138957 354.781134 404.6466575 1.140552918 0.189733384 0.521790326 1 4.097385211 4.595083567 9896 FIG4 phosphoinositide 5-phosphatase "GO:0000139,GO:0005515,GO:0005811,GO:0006661,GO:0010008,GO:0031901,GO:0031902,GO:0036092,GO:0043231,GO:0043813,GO:0046856" "Golgi membrane|protein binding|lipid droplet|phosphatidylinositol biosynthetic process|endosome membrane|early endosome membrane|late endosome membrane|phosphatidylinositol-3-phosphate biosynthetic process|intracellular membrane-bounded organelle|phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol dephosphorylation" "hsa00562,hsa05014,hsa05022" Inositol phosphate metabolism|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases FIGN 731.2366226 802.1591035 660.3141418 0.823171038 -0.280735871 0.270512902 1 2.160581258 1.748766661 55137 "fidgetin, microtubule severing factor" "GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005815,GO:0005874,GO:0007049,GO:0008022,GO:0008568,GO:0016363,GO:0016887,GO:0031122,GO:0051013,GO:0051301" protein binding|ATP binding|nucleus|cytoplasm|microtubule organizing center|microtubule|cell cycle|protein C-terminus binding|microtubule-severing ATPase activity|nuclear matrix|ATPase activity|cytoplasmic microtubule organization|microtubule severing|cell division FIGNL1 1975.921797 1924.765683 2027.077911 1.05315568 0.074718714 0.753791423 1 9.48400027 9.820990944 63979 fidgetin like 1 "GO:0000228,GO:0000287,GO:0001649,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0007140,GO:0008568,GO:0010569,GO:0016787,GO:0016887,GO:0031122,GO:0033687,GO:0043066,GO:0046034,GO:0048471,GO:0051013,GO:0051726,GO:0070062,GO:0071479,GO:2001243" nuclear chromosome|magnesium ion binding|osteoblast differentiation|protein binding|ATP binding|nucleus|cytoplasm|male meiotic nuclear division|microtubule-severing ATPase activity|regulation of double-strand break repair via homologous recombination|hydrolase activity|ATPase activity|cytoplasmic microtubule organization|osteoblast proliferation|negative regulation of apoptotic process|ATP metabolic process|perinuclear region of cytoplasm|microtubule severing|regulation of cell cycle|extracellular exosome|cellular response to ionizing radiation|negative regulation of intrinsic apoptotic signaling pathway FILIP1L 502.2946499 570.1468077 434.4424921 0.761983556 -0.39216823 0.150736368 1 4.529277648 3.393483344 11259 filamin A interacting protein 1 like "GO:0003674,GO:0005634,GO:0005737,GO:0008150,GO:0016020" molecular_function|nucleus|cytoplasm|biological_process|membrane FIP1L1 1270.413088 1179.829343 1360.996834 1.15355398 0.206085515 0.393283756 1 12.24053725 13.88383936 81608 factor interacting with PAPOLA and CPSF1 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005847,GO:0006369,GO:0006378,GO:0006406,GO:0031124,GO:0098789" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA export from nucleus|mRNA 3'-end processing|pre-mRNA cleavage required for polyadenylation" hsa03015 mRNA surveillance pathway FIS1 1180.372014 1112.202441 1248.541587 1.122584829 0.166824468 0.492599889 1 68.22551737 75.30731873 51024 "fission, mitochondrial 1" "GO:0000266,GO:0000422,GO:0001836,GO:0005515,GO:0005739,GO:0005777,GO:0005779,GO:0005783,GO:0006626,GO:0007204,GO:0008053,GO:0010821,GO:0016020,GO:0016559,GO:0031307,GO:0032471,GO:0032991,GO:0035584,GO:0042802,GO:0043280,GO:0043653,GO:0051561,GO:0070584,GO:0090141,GO:0090314,GO:1903579,GO:2000192,GO:2001244" mitochondrial fission|autophagy of mitochondrion|release of cytochrome c from mitochondria|protein binding|mitochondrion|peroxisome|integral component of peroxisomal membrane|endoplasmic reticulum|protein targeting to mitochondrion|positive regulation of cytosolic calcium ion concentration|mitochondrial fusion|regulation of mitochondrion organization|membrane|peroxisome fission|integral component of mitochondrial outer membrane|negative regulation of endoplasmic reticulum calcium ion concentration|protein-containing complex|calcium-mediated signaling using intracellular calcium source|identical protein binding|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|mitochondrial fragmentation involved in apoptotic process|positive regulation of mitochondrial calcium ion concentration|mitochondrion morphogenesis|positive regulation of mitochondrial fission|positive regulation of protein targeting to membrane|negative regulation of ATP metabolic process|negative regulation of fatty acid transport|positive regulation of intrinsic apoptotic signaling pathway hsa04137 Mitophagy - animal FITM2 461.3423405 428.6505196 494.0341614 1.152533681 0.204808912 0.465057596 1 4.943018671 5.601664 128486 fat storage inducing transmembrane protein 2 "GO:0005515,GO:0005789,GO:0007010,GO:0008654,GO:0010866,GO:0010890,GO:0017129,GO:0019915,GO:0019992,GO:0022604,GO:0030176,GO:0030730,GO:0034389,GO:0035356,GO:0036115,GO:0055088,GO:0140042" protein binding|endoplasmic reticulum membrane|cytoskeleton organization|phospholipid biosynthetic process|regulation of triglyceride biosynthetic process|positive regulation of sequestering of triglyceride|triglyceride binding|lipid storage|diacylglycerol binding|regulation of cell morphogenesis|integral component of endoplasmic reticulum membrane|sequestering of triglyceride|lipid droplet organization|cellular triglyceride homeostasis|fatty-acyl-CoA catabolic process|lipid homeostasis|lipid droplet formation FIZ1 127.6198917 133.172977 122.0668064 0.916603422 -0.125630423 0.785232833 1 1.872779188 1.687870906 84922 FLT3 interacting zinc finger 1 "GO:0000785,GO:0001102,GO:0001934,GO:0003713,GO:0005634,GO:0005737,GO:0030971,GO:0045944,GO:0046872" chromatin|RNA polymerase II activating transcription factor binding|positive regulation of protein phosphorylation|transcription coactivator activity|nucleus|cytoplasm|receptor tyrosine kinase binding|positive regulation of transcription by RNA polymerase II|metal ion binding FJX1 812.6423849 832.3311061 792.9536637 0.952690171 -0.069920991 0.784749709 1 18.46217015 17.29440449 24147 four-jointed box kinase 1 "GO:0005615,GO:0007267,GO:0010842" extracellular space|cell-cell signaling|retina layer formation FKBP10 4916.319782 5349.808185 4482.831379 0.83794245 -0.255076932 0.287658116 1 105.4318428 86.86746909 60681 FKBP prolyl isomerase 10 "GO:0000413,GO:0001701,GO:0003755,GO:0005509,GO:0005515,GO:0005528,GO:0005758,GO:0005783,GO:0005788,GO:0016020,GO:0017185,GO:0018208,GO:0030199,GO:0035909,GO:0042060,GO:0085029" protein peptidyl-prolyl isomerization|in utero embryonic development|peptidyl-prolyl cis-trans isomerase activity|calcium ion binding|protein binding|FK506 binding|mitochondrial intermembrane space|endoplasmic reticulum|endoplasmic reticulum lumen|membrane|peptidyl-lysine hydroxylation|peptidyl-proline modification|collagen fibril organization|aorta morphogenesis|wound healing|extracellular matrix assembly FKBP11 355.8781112 372.46817 339.2880525 0.910918247 -0.134606514 0.658426155 1 14.35230445 12.85500407 51303 FKBP prolyl isomerase 11 "GO:0000413,GO:0003755,GO:0016020,GO:0016021" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|membrane|integral component of membrane FKBP14 1049.427091 1080.990024 1017.864157 0.941603655 -0.086808175 0.725653474 1 11.58908212 10.72971915 55033 FKBP prolyl isomerase 14 "GO:0000413,GO:0003755,GO:0005509,GO:0005515,GO:0005788,GO:0036498" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|calcium ion binding|protein binding|endoplasmic reticulum lumen|IRE1-mediated unfolded protein response FKBP15 1636.515472 1820.724295 1452.30665 0.797653249 -0.326166371 0.17011629 1 11.02436002 8.646467329 23307 FKBP prolyl isomerase family member 15 "GO:0000413,GO:0003755,GO:0003779,GO:0005515,GO:0005769,GO:0006897,GO:0010923,GO:0016020,GO:0030426" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|actin binding|protein binding|early endosome|endocytosis|negative regulation of phosphatase activity|membrane|growth cone FKBP1A 15252.95009 13900.96989 16604.9303 1.194515953 0.256426122 0.329899102 1 395.6635808 464.7176956 2280 FKBP prolyl isomerase 1A "GO:0000413,GO:0003007,GO:0003755,GO:0005160,GO:0005515,GO:0005527,GO:0005528,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0007183,GO:0014802,GO:0016020,GO:0016529,GO:0019855,GO:0022417,GO:0030018,GO:0031312,GO:0031398,GO:0032092,GO:0032515,GO:0032880,GO:0032925,GO:0034713,GO:0042026,GO:0042110,GO:0043123,GO:0044325,GO:0046332,GO:0048185,GO:0050776,GO:0051280,GO:0055010,GO:0060314,GO:0060315,GO:0060347,GO:0061077,GO:0070588,GO:0097435,GO:0098562,GO:1901393,GO:1902991,GO:1990000,GO:1990425" protein peptidyl-prolyl isomerization|heart morphogenesis|peptidyl-prolyl cis-trans isomerase activity|transforming growth factor beta receptor binding|protein binding|macrolide binding|FK506 binding|cytoplasm|cytosol|protein folding|'de novo' protein folding|SMAD protein complex assembly|terminal cisterna|membrane|sarcoplasmic reticulum|calcium channel inhibitor activity|protein maturation by protein folding|Z disc|extrinsic component of organelle membrane|positive regulation of protein ubiquitination|positive regulation of protein binding|negative regulation of phosphoprotein phosphatase activity|regulation of protein localization|regulation of activin receptor signaling pathway|type I transforming growth factor beta receptor binding|protein refolding|T cell activation|positive regulation of I-kappaB kinase/NF-kappaB signaling|ion channel binding|SMAD binding|activin binding|regulation of immune response|negative regulation of release of sequestered calcium ion into cytosol|ventricular cardiac muscle tissue morphogenesis|regulation of ryanodine-sensitive calcium-release channel activity|negative regulation of ryanodine-sensitive calcium-release channel activity|heart trabecula formation|chaperone-mediated protein folding|calcium ion transmembrane transport|supramolecular fiber organization|cytoplasmic side of membrane|negative regulation of transforming growth factor beta1 activation|regulation of amyloid precursor protein catabolic process|amyloid fibril formation|ryanodine receptor complex FKBP1B 408.2013602 421.3676225 395.0350979 0.937507005 -0.093098624 0.752870019 1 6.135775053 5.656074609 2281 FKBP prolyl isomerase 1B "GO:0000413,GO:0003755,GO:0005102,GO:0005219,GO:0005515,GO:0005528,GO:0005737,GO:0005829,GO:0006458,GO:0006939,GO:0009749,GO:0010459,GO:0010880,GO:0010881,GO:0016020,GO:0019227,GO:0019855,GO:0022417,GO:0030018,GO:0030073,GO:0030551,GO:0032515,GO:0033017,GO:0033197,GO:0034220,GO:0034704,GO:0035584,GO:0042026,GO:0042098,GO:0042542,GO:0044325,GO:0048680,GO:0051209,GO:0051280,GO:0051284,GO:0051480,GO:0051775,GO:0060314,GO:0060315,GO:0061077,GO:0061179,GO:0086064,GO:1903779" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|signaling receptor binding|ryanodine-sensitive calcium-release channel activity|protein binding|FK506 binding|cytoplasm|cytosol|'de novo' protein folding|smooth muscle contraction|response to glucose|negative regulation of heart rate|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|membrane|neuronal action potential propagation|calcium channel inhibitor activity|protein maturation by protein folding|Z disc|insulin secretion|cyclic nucleotide binding|negative regulation of phosphoprotein phosphatase activity|sarcoplasmic reticulum membrane|response to vitamin E|ion transmembrane transport|calcium channel complex|calcium-mediated signaling using intracellular calcium source|protein refolding|T cell proliferation|response to hydrogen peroxide|ion channel binding|positive regulation of axon regeneration|release of sequestered calcium ion into cytosol|negative regulation of release of sequestered calcium ion into cytosol|positive regulation of sequestering of calcium ion|regulation of cytosolic calcium ion concentration|response to redox state|regulation of ryanodine-sensitive calcium-release channel activity|negative regulation of ryanodine-sensitive calcium-release channel activity|chaperone-mediated protein folding|negative regulation of insulin secretion involved in cellular response to glucose stimulus|cell communication by electrical coupling involved in cardiac conduction|regulation of cardiac conduction FKBP3 1845.623456 1481.549369 2209.697543 1.491477496 0.57674221 0.015107117 0.714843697 20.25815189 29.70897762 2287 FKBP prolyl isomerase 3 "GO:0000413,GO:0003723,GO:0003755,GO:0005515,GO:0005528,GO:0005634,GO:0038023" protein peptidyl-prolyl isomerization|RNA binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|FK506 binding|nucleus|signaling receptor activity FKBP4 2496.231804 2311.799647 2680.663961 1.159557215 0.213574008 0.366482457 1 34.82260747 39.70312112 2288 FKBP prolyl isomerase 4 "GO:0000413,GO:0003723,GO:0003755,GO:0005515,GO:0005528,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005874,GO:0006457,GO:0006825,GO:0010977,GO:0030674,GO:0031072,GO:0031111,GO:0031115,GO:0032767,GO:0032991,GO:0043025,GO:0044295,GO:0048156,GO:0048471,GO:0061077,GO:0070062,GO:1900034" protein peptidyl-prolyl isomerization|RNA binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|FK506 binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|microtubule|protein folding|copper ion transport|negative regulation of neuron projection development|protein-macromolecule adaptor activity|heat shock protein binding|negative regulation of microtubule polymerization or depolymerization|negative regulation of microtubule polymerization|copper-dependent protein binding|protein-containing complex|neuronal cell body|axonal growth cone|tau protein binding|perinuclear region of cytoplasm|chaperone-mediated protein folding|extracellular exosome|regulation of cellular response to heat hsa04915 Estrogen signaling pathway FKBP5 680.9998462 644.0161934 717.9834991 1.114853177 0.156853724 0.544727395 1 3.24367314 3.555706772 2289 FKBP prolyl isomerase 5 "GO:0000413,GO:0003755,GO:0005515,GO:0005528,GO:0005654,GO:0005737,GO:0005829,GO:0006457,GO:0009617,GO:0016020,GO:0031072,GO:0061077,GO:0070062" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|protein binding|FK506 binding|nucleoplasm|cytoplasm|cytosol|protein folding|response to bacterium|membrane|heat shock protein binding|chaperone-mediated protein folding|extracellular exosome hsa04915 Estrogen signaling pathway FKBP7 139.312279 137.3346325 141.2899255 1.028800405 0.040963116 0.940221128 1 2.598120144 2.628218907 51661 FKBP prolyl isomerase 7 "GO:0000413,GO:0003755,GO:0005509,GO:0005515,GO:0005528,GO:0005783,GO:0005788,GO:0018208" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|calcium ion binding|protein binding|FK506 binding|endoplasmic reticulum|endoplasmic reticulum lumen|peptidyl-proline modification FKBP8 3494.184174 3126.443717 3861.924631 1.235245212 0.304797463 0.199166264 1 94.74875357 115.0794727 23770 FKBP prolyl isomerase 8 "GO:0000413,GO:0001708,GO:0001933,GO:0003755,GO:0005515,GO:0005739,GO:0005783,GO:0005829,GO:0006457,GO:0006915,GO:0007224,GO:0010468,GO:0016020,GO:0016032,GO:0021904,GO:0030176,GO:0030513,GO:0031966,GO:0032991,GO:0035264,GO:0035556,GO:0042802,GO:0043010,GO:0043066,GO:0044183,GO:0046872,GO:0097718" protein peptidyl-prolyl isomerization|cell fate specification|negative regulation of protein phosphorylation|peptidyl-prolyl cis-trans isomerase activity|protein binding|mitochondrion|endoplasmic reticulum|cytosol|protein folding|apoptotic process|smoothened signaling pathway|regulation of gene expression|membrane|viral process|dorsal/ventral neural tube patterning|integral component of endoplasmic reticulum membrane|positive regulation of BMP signaling pathway|mitochondrial membrane|protein-containing complex|multicellular organism growth|intracellular signal transduction|identical protein binding|camera-type eye development|negative regulation of apoptotic process|protein folding chaperone|metal ion binding|disordered domain specific binding FKBP9 2881.85679 3402.153396 2361.560184 0.694136892 -0.526707888 0.026213334 0.866576205 31.35325054 21.39926605 11328 FKBP prolyl isomerase 9 "GO:0000413,GO:0003755,GO:0005509,GO:0005783,GO:0006457" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|calcium ion binding|endoplasmic reticulum|protein folding FKBPL 97.43279784 110.2838716 84.58172413 0.766945546 -0.382803946 0.423316133 1 4.385728414 3.307329335 63943 FKBP prolyl isomerase like "GO:0005515,GO:0005576,GO:0005829,GO:0009314,GO:0050821,GO:1905553" protein binding|extracellular region|cytosol|response to radiation|protein stabilization|regulation of blood vessel branching FKRP 156.706821 202.8807071 110.5329349 0.544817378 -0.876155373 0.028203057 0.877967194 3.161276047 1.693497466 79147 fukutin related protein "GO:0000139,GO:0002162,GO:0005615,GO:0005654,GO:0005791,GO:0005794,GO:0005829,GO:0016021,GO:0016485,GO:0016740,GO:0035269,GO:0042383" Golgi membrane|dystroglycan binding|extracellular space|nucleoplasm|rough endoplasmic reticulum|Golgi apparatus|cytosol|integral component of membrane|protein processing|transferase activity|protein O-linked mannosylation|sarcolemma hsa00515 Mannose type O-glycan biosynthesis FKTN 1189.680404 1268.264523 1111.096285 0.876076138 -0.190871838 0.431633338 1 4.865919958 4.191582232 2218 fukutin "GO:0005515,GO:0005615,GO:0005634,GO:0005783,GO:0005794,GO:0005801,GO:0006493,GO:0007399,GO:0007517,GO:0008285,GO:0016740,GO:0030173,GO:0035269,GO:0046329,GO:0060049" protein binding|extracellular space|nucleus|endoplasmic reticulum|Golgi apparatus|cis-Golgi network|protein O-linked glycosylation|nervous system development|muscle organ development|negative regulation of cell population proliferation|transferase activity|integral component of Golgi membrane|protein O-linked mannosylation|negative regulation of JNK cascade|regulation of protein glycosylation hsa00515 Mannose type O-glycan biosynthesis FLACC1 12.00941903 12.48496659 11.53387147 0.923820772 -0.11431511 1 1 0.213352456 0.193801239 130540 flagellum associated containing coiled-coil domains 1 "GO:0001520,GO:0003674,GO:0005515,GO:0005575,GO:0005737,GO:0035686,GO:0036126" outer dense fiber|molecular_function|protein binding|cellular_component|cytoplasm|sperm fibrous sheath|sperm flagellum FLAD1 525.4265595 609.6825352 441.1705838 0.723607055 -0.466721621 0.083951755 1 12.77488667 9.089312334 80308 flavin adenine dinucleotide synthetase 1 "GO:0003919,GO:0005515,GO:0005524,GO:0005759,GO:0005829,GO:0005886,GO:0006747,GO:0006771,GO:0042802" FMN adenylyltransferase activity|protein binding|ATP binding|mitochondrial matrix|cytosol|plasma membrane|FAD biosynthetic process|riboflavin metabolic process|identical protein binding hsa00740 Riboflavin metabolism FLCN 987.6250316 1199.597207 775.6528565 0.646594417 -0.629067044 0.010671466 0.620526829 10.45229358 6.645302089 201163 folliculin "GO:0000122,GO:0001701,GO:0001932,GO:0001934,GO:0005085,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005765,GO:0005813,GO:0005829,GO:0005886,GO:0005929,GO:0007043,GO:0009267,GO:0010508,GO:0010629,GO:0010823,GO:0030097,GO:0030308,GO:0030336,GO:0030496,GO:0030511,GO:0031929,GO:0032006,GO:0032007,GO:0032008,GO:0032418,GO:0032465,GO:0034198,GO:0035024,GO:0035065,GO:0043065,GO:0043547,GO:0044291,GO:0044877,GO:0045785,GO:0045944,GO:0046578,GO:0051898,GO:0070373,GO:0072686,GO:0097009,GO:0120163,GO:1900181,GO:1901723,GO:1903444,GO:1904263,GO:2000973,GO:2001170" negative regulation of transcription by RNA polymerase II|in utero embryonic development|regulation of protein phosphorylation|positive regulation of protein phosphorylation|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|nucleus|cytoplasm|lysosome|lysosomal membrane|centrosome|cytosol|plasma membrane|cilium|cell-cell junction assembly|cellular response to starvation|positive regulation of autophagy|negative regulation of gene expression|negative regulation of mitochondrion organization|hemopoiesis|negative regulation of cell growth|negative regulation of cell migration|midbody|positive regulation of transforming growth factor beta receptor signaling pathway|TOR signaling|regulation of TOR signaling|negative regulation of TOR signaling|positive regulation of TOR signaling|lysosome localization|regulation of cytokinesis|cellular response to amino acid starvation|negative regulation of Rho protein signal transduction|regulation of histone acetylation|positive regulation of apoptotic process|positive regulation of GTPase activity|cell-cell contact zone|protein-containing complex binding|positive regulation of cell adhesion|positive regulation of transcription by RNA polymerase II|regulation of Ras protein signal transduction|negative regulation of protein kinase B signaling|negative regulation of ERK1 and ERK2 cascade|mitotic spindle|energy homeostasis|negative regulation of cold-induced thermogenesis|negative regulation of protein localization to nucleus|negative regulation of cell proliferation involved in kidney development|negative regulation of brown fat cell differentiation|positive regulation of TORC1 signaling|regulation of pro-B cell differentiation|negative regulation of ATP biosynthetic process "hsa04150,hsa05211" mTOR signaling pathway|Renal cell carcinoma FLI1 703.0064392 792.7953786 613.2174999 0.773487733 -0.370549684 0.147717573 1 8.289583123 6.304596545 2313 "Fli-1 proto-oncogene, ETS transcription factor" "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007599,GO:0008015,GO:0009887,GO:0016604,GO:0030154,GO:0035855,GO:0045893,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|hemostasis|blood circulation|animal organ morphogenesis|nuclear body|cell differentiation|megakaryocyte development|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" hsa05202 Transcriptional misregulation in cancer ETS FLII 5485.733645 5625.517863 5345.949427 0.95030352 -0.073539722 0.760787234 1 63.51249188 59.34616625 2314 FLII actin remodeling protein "GO:0003779,GO:0005515,GO:0005546,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005903,GO:0005925,GO:0007275,GO:0008154,GO:0015629,GO:0030239,GO:0034451,GO:0051014,GO:0051015,GO:0051016" "actin binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|nucleus|nucleoplasm|cytoplasm|cytosol|brush border|focal adhesion|multicellular organism development|actin polymerization or depolymerization|actin cytoskeleton|myofibril assembly|centriolar satellite|actin filament severing|actin filament binding|barbed-end actin filament capping" FLNA 66677.35942 69357.11066 63997.60817 0.922725984 -0.116025811 0.739560292 1 435.1077375 394.7669038 2316 filamin A "GO:0001525,GO:0001664,GO:0001837,GO:0001974,GO:0002576,GO:0003007,GO:0003723,GO:0005080,GO:0005515,GO:0005576,GO:0005634,GO:0005730,GO:0005737,GO:0005802,GO:0005829,GO:0005884,GO:0005886,GO:0005903,GO:0005911,GO:0005925,GO:0007195,GO:0008134,GO:0010977,GO:0015459,GO:0015629,GO:0016020,GO:0016479,GO:0019900,GO:0021943,GO:0021987,GO:0030018,GO:0030168,GO:0030334,GO:0030863,GO:0031267,GO:0031523,GO:0031532,GO:0031852,GO:0032233,GO:0032432,GO:0034329,GO:0034394,GO:0034988,GO:0042177,GO:0042307,GO:0042789,GO:0042803,GO:0043066,GO:0043113,GO:0043123,GO:0043198,GO:0043204,GO:0043433,GO:0044295,GO:0044319,GO:0044325,GO:0045022,GO:0045184,GO:0045216,GO:0045296,GO:0046332,GO:0048471,GO:0048680,GO:0050808,GO:0050821,GO:0051015,GO:0051020,GO:0051220,GO:0051607,GO:0051764,GO:0060271,GO:0070062,GO:0070527,GO:0071526,GO:0072659,GO:0090042,GO:0090307,GO:0097368,GO:0097440,GO:0098794,GO:0098978,GO:1900026,GO:1901381,GO:1902396,GO:1905000,GO:1905031,GO:2000179,GO:2001046,GO:2001224" "angiogenesis|G protein-coupled receptor binding|epithelial to mesenchymal transition|blood vessel remodeling|platelet degranulation|heart morphogenesis|RNA binding|protein kinase C binding|protein binding|extracellular region|nucleus|nucleolus|cytoplasm|trans-Golgi network|cytosol|actin filament|plasma membrane|brush border|cell-cell junction|focal adhesion|adenylate cyclase-inhibiting dopamine receptor signaling pathway|transcription factor binding|negative regulation of neuron projection development|potassium channel regulator activity|actin cytoskeleton|membrane|negative regulation of transcription by RNA polymerase I|kinase binding|formation of radial glial scaffolds|cerebral cortex development|Z disc|platelet activation|regulation of cell migration|cortical cytoskeleton|small GTPase binding|Myb complex|actin cytoskeleton reorganization|mu-type opioid receptor binding|positive regulation of actin filament bundle assembly|actin filament bundle|cell junction assembly|protein localization to cell surface|Fc-gamma receptor I complex binding|negative regulation of protein catabolic process|positive regulation of protein import into nucleus|mRNA transcription by RNA polymerase II|protein homodimerization activity|negative regulation of apoptotic process|receptor clustering|positive regulation of I-kappaB kinase/NF-kappaB signaling|dendritic shaft|perikaryon|negative regulation of DNA-binding transcription factor activity|axonal growth cone|wound healing, spreading of cells|ion channel binding|early endosome to late endosome transport|establishment of protein localization|cell-cell junction organization|cadherin binding|SMAD binding|perinuclear region of cytoplasm|positive regulation of axon regeneration|synapse organization|protein stabilization|actin filament binding|GTPase binding|cytoplasmic sequestering of protein|defense response to virus|actin crosslink formation|cilium assembly|extracellular exosome|platelet aggregation|semaphorin-plexin signaling pathway|protein localization to plasma membrane|tubulin deacetylation|mitotic spindle assembly|establishment of Sertoli cell barrier|apical dendrite|postsynapse|glutamatergic synapse|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of potassium ion transmembrane transport|protein localization to bicellular tight junction|regulation of membrane repolarization during atrial cardiac muscle cell action potential|regulation of membrane repolarization during cardiac muscle cell action potential|positive regulation of neural precursor cell proliferation|positive regulation of integrin-mediated signaling pathway|positive regulation of neuron migration" "hsa04010,hsa04510,hsa05132,hsa05205" MAPK signaling pathway|Focal adhesion|Salmonella infection|Proteoglycans in cancer FLNB 18324.55285 17805.64319 18843.46252 1.058285978 0.081729536 0.761953149 1 100.0162563 104.0746155 2317 filamin B "GO:0003723,GO:0003779,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0005938,GO:0007165,GO:0007517,GO:0015629,GO:0016021,GO:0030018,GO:0030036,GO:0030154,GO:0042802,GO:0043005,GO:0043025,GO:0045296,GO:0070062" RNA binding|actin binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|focal adhesion|cell cortex|signal transduction|muscle organ development|actin cytoskeleton|integral component of membrane|Z disc|actin cytoskeleton organization|cell differentiation|identical protein binding|neuron projection|neuronal cell body|cadherin binding|extracellular exosome "hsa04010,hsa04510,hsa05132,hsa05205" MAPK signaling pathway|Focal adhesion|Salmonella infection|Proteoglycans in cancer FLNC 8982.726561 9633.192139 8332.260983 0.864953264 -0.209305913 0.400550224 1 56.13121077 47.73844083 2318 filamin C "GO:0003779,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0008092,GO:0016528,GO:0030018,GO:0030506,GO:0034329,GO:0042383,GO:0043034,GO:0048747" actin binding|protein binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|focal adhesion|cytoskeletal protein binding|sarcoplasm|Z disc|ankyrin binding|cell junction assembly|sarcolemma|costamere|muscle fiber development "hsa04010,hsa04510,hsa05132,hsa05205" MAPK signaling pathway|Focal adhesion|Salmonella infection|Proteoglycans in cancer FLOT1 3418.474922 3271.061247 3565.888597 1.090132018 0.124502859 0.600223223 1 87.06759441 93.32689549 10211 flotillin 1 "GO:0001765,GO:0001819,GO:0001931,GO:0001934,GO:0002020,GO:0002090,GO:0005515,GO:0005765,GO:0005768,GO:0005769,GO:0005815,GO:0005886,GO:0005901,GO:0005911,GO:0005912,GO:0005925,GO:0007409,GO:0008180,GO:0009897,GO:0016020,GO:0016323,GO:0016324,GO:0016600,GO:0022617,GO:0030027,GO:0030864,GO:0031410,GO:0032092,GO:0032226,GO:0032728,GO:0033227,GO:0034116,GO:0034141,GO:0034143,GO:0034451,GO:0034976,GO:0035023,GO:0035255,GO:0042383,GO:0042470,GO:0044291,GO:0044854,GO:0045121,GO:0045807,GO:0048643,GO:0048786,GO:0050821,GO:0051092,GO:0051580,GO:0060355,GO:0070062,GO:0070528,GO:0071360,GO:0072659,GO:0098691,GO:0098978,GO:0098982,GO:1901741,GO:1901890,GO:1903044,GO:2000049" "membrane raft assembly|positive regulation of cytokine production|uropod|positive regulation of protein phosphorylation|protease binding|regulation of receptor internalization|protein binding|lysosomal membrane|endosome|early endosome|microtubule organizing center|plasma membrane|caveola|cell-cell junction|adherens junction|focal adhesion|axonogenesis|COP9 signalosome|external side of plasma membrane|membrane|basolateral plasma membrane|apical plasma membrane|flotillin complex|extracellular matrix disassembly|lamellipodium|cortical actin cytoskeleton|cytoplasmic vesicle|positive regulation of protein binding|positive regulation of synaptic transmission, dopaminergic|positive regulation of interferon-beta production|dsRNA transport|positive regulation of heterotypic cell-cell adhesion|positive regulation of toll-like receptor 3 signaling pathway|regulation of toll-like receptor 4 signaling pathway|centriolar satellite|response to endoplasmic reticulum stress|regulation of Rho protein signal transduction|ionotropic glutamate receptor binding|sarcolemma|melanosome|cell-cell contact zone|plasma membrane raft assembly|membrane raft|positive regulation of endocytosis|positive regulation of skeletal muscle tissue development|presynaptic active zone|protein stabilization|positive regulation of NF-kappaB transcription factor activity|regulation of neurotransmitter uptake|positive regulation of cell adhesion molecule production|extracellular exosome|protein kinase C signaling|cellular response to exogenous dsRNA|protein localization to plasma membrane|dopaminergic synapse|glutamatergic synapse|GABA-ergic synapse|positive regulation of myoblast fusion|positive regulation of cell junction assembly|protein localization to membrane raft|positive regulation of cell-cell adhesion mediated by cadherin" hsa04910 Insulin signaling pathway FLOT2 1663.596416 1799.916017 1527.276814 0.848526709 -0.236968023 0.318870396 1 34.11158016 28.46023838 2319 flotillin 2 "GO:0001765,GO:0001931,GO:0005515,GO:0005768,GO:0005886,GO:0005901,GO:0005912,GO:0005925,GO:0007155,GO:0008544,GO:0010629,GO:0016020,GO:0016323,GO:0016324,GO:0016600,GO:0030027,GO:0030139,GO:0030864,GO:0031410,GO:0031982,GO:0034114,GO:0034139,GO:0043231,GO:0044291,GO:0044860,GO:0045661,GO:0048471,GO:0050821,GO:0051092,GO:0070062,GO:0072659,GO:1902992,GO:1903905" membrane raft assembly|uropod|protein binding|endosome|plasma membrane|caveola|adherens junction|focal adhesion|cell adhesion|epidermis development|negative regulation of gene expression|membrane|basolateral plasma membrane|apical plasma membrane|flotillin complex|lamellipodium|endocytic vesicle|cortical actin cytoskeleton|cytoplasmic vesicle|vesicle|regulation of heterotypic cell-cell adhesion|regulation of toll-like receptor 3 signaling pathway|intracellular membrane-bounded organelle|cell-cell contact zone|protein localization to plasma membrane raft|regulation of myoblast differentiation|perinuclear region of cytoplasm|protein stabilization|positive regulation of NF-kappaB transcription factor activity|extracellular exosome|protein localization to plasma membrane|negative regulation of amyloid precursor protein catabolic process|positive regulation of establishment of T cell polarity hsa04910 Insulin signaling pathway FLRT1 3.601819626 6.242483296 0.961155956 0.153970129 -2.699277611 0.237188726 1 0.026622172 0.004030428 23769 fibronectin leucine rich transmembrane protein 1 "GO:0005615,GO:0005789,GO:0005886,GO:0005887,GO:0005911,GO:0005925,GO:0007155,GO:0008543,GO:0016358,GO:0030659,GO:0030674,GO:0031012,GO:0031410,GO:0032809,GO:0044306,GO:0048471,GO:1990138" extracellular space|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|cell adhesion|fibroblast growth factor receptor signaling pathway|dendrite development|cytoplasmic vesicle membrane|protein-macromolecule adaptor activity|extracellular matrix|cytoplasmic vesicle|neuronal cell body membrane|neuron projection terminus|perinuclear region of cytoplasm|neuron projection extension FLRT2 806.5980464 825.0482089 788.1478839 0.955274947 -0.066012066 0.797028232 1 2.09583067 1.968592191 23768 fibronectin leucine rich transmembrane protein 2 "GO:0003007,GO:0005104,GO:0005615,GO:0005789,GO:0005886,GO:0005887,GO:0005911,GO:0005925,GO:0007411,GO:0008150,GO:0008543,GO:0030674,GO:0031012,GO:0043005,GO:0045202,GO:0045499,GO:0050919,GO:0051965,GO:0061343,GO:0070062,GO:0071711,GO:2001222" heart morphogenesis|fibroblast growth factor receptor binding|extracellular space|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|axon guidance|biological_process|fibroblast growth factor receptor signaling pathway|protein-macromolecule adaptor activity|extracellular matrix|neuron projection|synapse|chemorepellent activity|negative chemotaxis|positive regulation of synapse assembly|cell adhesion involved in heart morphogenesis|extracellular exosome|basement membrane organization|regulation of neuron migration FLRT3 5.16244045 9.363724944 0.961155956 0.102646752 -3.284240111 0.082212168 1 0.088165983 0.008898513 23767 fibronectin leucine rich transmembrane protein 3 "GO:0003345,GO:0005104,GO:0005515,GO:0005615,GO:0005789,GO:0005829,GO:0005886,GO:0005887,GO:0005911,GO:0005925,GO:0007411,GO:0007416,GO:0007507,GO:0008543,GO:0030054,GO:0030674,GO:0031012,GO:0031175,GO:0032584,GO:0042803,GO:0043679,GO:0044295,GO:0045499,GO:0048598,GO:0048678,GO:0050919,GO:0051965,GO:0060322,GO:0097060,GO:0098742,GO:0098978,GO:0099055,GO:0099560,GO:1990138" proepicardium cell migration involved in pericardium morphogenesis|fibroblast growth factor receptor binding|protein binding|extracellular space|endoplasmic reticulum membrane|cytosol|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|axon guidance|synapse assembly|heart development|fibroblast growth factor receptor signaling pathway|cell junction|protein-macromolecule adaptor activity|extracellular matrix|neuron projection development|growth cone membrane|protein homodimerization activity|axon terminus|axonal growth cone|chemorepellent activity|embryonic morphogenesis|response to axon injury|negative chemotaxis|positive regulation of synapse assembly|head development|synaptic membrane|cell-cell adhesion via plasma-membrane adhesion molecules|glutamatergic synapse|integral component of postsynaptic membrane|synaptic membrane adhesion|neuron projection extension FLT3LG 100.6433583 93.63724944 107.6494671 1.149643627 0.201186716 0.68098799 1 3.521668714 3.980915084 2323 fms related receptor tyrosine kinase 3 ligand "GO:0000165,GO:0005102,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0007165,GO:0008284,GO:0009986,GO:0016020,GO:0016021,GO:0019221,GO:0030971,GO:0032819,GO:0035162" MAPK cascade|signaling receptor binding|cytokine activity|protein binding|extracellular region|extracellular space|plasma membrane|signal transduction|positive regulation of cell population proliferation|cell surface|membrane|integral component of membrane|cytokine-mediated signaling pathway|receptor tyrosine kinase binding|positive regulation of natural killer cell proliferation|embryonic hemopoiesis "hsa04010,hsa04014,hsa04151,hsa04640,hsa05200" MAPK signaling pathway|Ras signaling pathway|PI3K-Akt signaling pathway|Hematopoietic cell lineage|Pathways in cancer FLVCR1 174.4089483 200.7998793 148.0180172 0.737141963 -0.439985606 0.251670471 1 3.596080707 2.606464075 28982 FLVCR heme transporter 1 "GO:0001568,GO:0001701,GO:0005515,GO:0005739,GO:0005886,GO:0006839,GO:0006879,GO:0015232,GO:0015886,GO:0016021,GO:0020037,GO:0030218,GO:0031966,GO:0035264,GO:0042733,GO:0043249,GO:0046620,GO:0048536,GO:0048704,GO:0055085,GO:0060323,GO:0097037" blood vessel development|in utero embryonic development|protein binding|mitochondrion|plasma membrane|mitochondrial transport|cellular iron ion homeostasis|heme transmembrane transporter activity|heme transport|integral component of membrane|heme binding|erythrocyte differentiation|mitochondrial membrane|multicellular organism growth|embryonic digit morphogenesis|erythrocyte maturation|regulation of organ growth|spleen development|embryonic skeletal system morphogenesis|transmembrane transport|head morphogenesis|heme export FLVCR2 15.37346488 12.48496659 18.26196316 1.462716222 0.548649903 0.600554067 1 0.179402186 0.258023337 55640 FLVCR heme transporter 2 "GO:0005886,GO:0015232,GO:0016021,GO:0020037,GO:0055085,GO:0097037" plasma membrane|heme transmembrane transporter activity|integral component of membrane|heme binding|transmembrane transport|heme export FLYWCH1 1029.906447 1123.646993 936.1659011 0.833149474 -0.263352745 0.283021019 1 11.36168527 9.307581713 84256 FLYWCH-type zinc finger 1 "GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0016604,GO:0046872" DNA binding|protein binding|nucleoplasm|cytosol|nuclear body|metal ion binding FLYWCH2 311.6605212 284.03299 339.2880525 1.194537481 0.256452122 0.412461899 1 10.81964214 12.70819461 114984 FLYWCH family member 2 "GO:0003723,GO:0005575,GO:0008150" RNA binding|cellular_component|biological_process FMC1 2.40288989 0 4.80577978 Inf Inf 0.18976424 1 0 0.248702033 154791 formation of mitochondrial complex V assembly factor 1 homolog "GO:0005515,GO:0005739,GO:0033615,GO:0050995,GO:0061469" protein binding|mitochondrion|mitochondrial proton-transporting ATP synthase complex assembly|negative regulation of lipid catabolic process|regulation of type B pancreatic cell proliferation FMN1 19.81252315 28.09117483 11.53387147 0.41058701 -1.284240111 0.135928254 1 0.058749681 0.023718209 342184 formin 1 "GO:0003779,GO:0005634,GO:0005737,GO:0005789,GO:0005884,GO:0005886,GO:0005912,GO:0008017,GO:0010467,GO:0017124,GO:0035136,GO:0035137,GO:0045010,GO:0048705,GO:0051127,GO:0051894,GO:0072092" actin binding|nucleus|cytoplasm|endoplasmic reticulum membrane|actin filament|plasma membrane|adherens junction|microtubule binding|gene expression|SH3 domain binding|forelimb morphogenesis|hindlimb morphogenesis|actin nucleation|skeletal system morphogenesis|positive regulation of actin nucleation|positive regulation of focal adhesion assembly|ureteric bud invasion FMN2 26.66453215 18.72744989 34.60161442 1.847641543 0.88568489 0.250015273 1 0.102824031 0.186802861 56776 formin 2 "GO:0003674,GO:0003779,GO:0005634,GO:0005730,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0005886,GO:0005938,GO:0006974,GO:0007275,GO:0015031,GO:0015629,GO:0016192,GO:0030659,GO:0035556,GO:0040038,GO:0042177,GO:0043066,GO:0046907,GO:0048471,GO:0048477,GO:0051295,GO:0051758,GO:0070649,GO:0071456,GO:2000781" molecular_function|actin binding|nucleus|nucleolus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|plasma membrane|cell cortex|cellular response to DNA damage stimulus|multicellular organism development|protein transport|actin cytoskeleton|vesicle-mediated transport|cytoplasmic vesicle membrane|intracellular signal transduction|polar body extrusion after meiotic divisions|negative regulation of protein catabolic process|negative regulation of apoptotic process|intracellular transport|perinuclear region of cytoplasm|oogenesis|establishment of meiotic spindle localization|homologous chromosome movement towards spindle pole in meiosis I anaphase|formin-nucleated actin cable assembly|cellular response to hypoxia|positive regulation of double-strand break repair FMNL1 1136.713645 1126.768235 1146.659056 1.017652983 0.02524569 0.921071285 1 9.551072075 9.557031358 752 formin like 1 "GO:0003674,GO:0005515,GO:0005829,GO:0005886,GO:0005938,GO:0008360,GO:0016020,GO:0016477,GO:0030866,GO:0031267,GO:0032059,GO:0032794,GO:0045335,GO:0051014,GO:0051015,GO:0070062" molecular_function|protein binding|cytosol|plasma membrane|cell cortex|regulation of cell shape|membrane|cell migration|cortical actin cytoskeleton organization|small GTPase binding|bleb|GTPase activating protein binding|phagocytic vesicle|actin filament severing|actin filament binding|extracellular exosome FMNL2 3086.487315 2844.491555 3328.483076 1.170150451 0.226694035 0.338584886 1 21.82364669 25.10962373 114793 formin like 2 "GO:0005829,GO:0007010,GO:0008360,GO:0016477,GO:0022604,GO:0030866,GO:0045296,GO:0051015" cytosol|cytoskeleton organization|regulation of cell shape|cell migration|regulation of cell morphogenesis|cortical actin cytoskeleton organization|cadherin binding|actin filament binding FMNL3 1261.008506 1361.901772 1160.115239 0.851834738 -0.231354531 0.337827046 1 5.239111549 4.38817734 91010 formin like 3 "GO:0001525,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0007010,GO:0008360,GO:0016477,GO:0030866,GO:0032794,GO:0043231,GO:0051015" angiogenesis|cytoplasm|Golgi apparatus|cytosol|plasma membrane|cytoskeleton organization|regulation of cell shape|cell migration|cortical actin cytoskeleton organization|GTPase activating protein binding|intracellular membrane-bounded organelle|actin filament binding FMO3 7.367185523 4.161655531 10.57271552 2.540507122 1.345116509 0.341208165 1 0.100135215 0.250137284 2328 flavin containing dimethylaniline monoxygenase 3 "GO:0004497,GO:0004499,GO:0005515,GO:0005789,GO:0006805,GO:0016021,GO:0034899,GO:0043231,GO:0050660,GO:0050661,GO:0055114" "monooxygenase activity|N,N-dimethylaniline monooxygenase activity|protein binding|endoplasmic reticulum membrane|xenobiotic metabolic process|integral component of membrane|trimethylamine monooxygenase activity|intracellular membrane-bounded organelle|flavin adenine dinucleotide binding|NADP binding|oxidation-reduction process" hsa00982 Drug metabolism - cytochrome P450 FMO4 43.35581366 40.57614142 46.13548589 1.137010181 0.185245172 0.800810665 1 0.646603193 0.72289193 2329 flavin containing dimethylaniline monoxygenase 4 "GO:0004497,GO:0004499,GO:0005515,GO:0005789,GO:0016021,GO:0042737,GO:0050660,GO:0050661,GO:0055114" "monooxygenase activity|N,N-dimethylaniline monooxygenase activity|protein binding|endoplasmic reticulum membrane|integral component of membrane|drug catabolic process|flavin adenine dinucleotide binding|NADP binding|oxidation-reduction process" hsa00982 Drug metabolism - cytochrome P450 FMO5 63.29225412 59.30359131 67.28091692 1.134516737 0.182077893 0.763907481 1 0.405136159 0.451942405 2330 flavin containing dimethylaniline monoxygenase 5 "GO:0004031,GO:0004497,GO:0004499,GO:0005783,GO:0005789,GO:0005829,GO:0016021,GO:0016174,GO:0017144,GO:0050660,GO:0050661,GO:0055114,GO:0070995,GO:0090181" "aldehyde oxidase activity|monooxygenase activity|N,N-dimethylaniline monooxygenase activity|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|integral component of membrane|NAD(P)H oxidase H2O2-forming activity|drug metabolic process|flavin adenine dinucleotide binding|NADP binding|oxidation-reduction process|NADPH oxidation|regulation of cholesterol metabolic process" hsa00982 Drug metabolism - cytochrome P450 FMOD 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.018866795 0.068551508 2331 fibromodulin "GO:0005576,GO:0005615,GO:0005796,GO:0007181,GO:0018146,GO:0030021,GO:0030199,GO:0031012,GO:0042340,GO:0043202,GO:0062023" extracellular region|extracellular space|Golgi lumen|transforming growth factor beta receptor complex assembly|keratan sulfate biosynthetic process|extracellular matrix structural constituent conferring compression resistance|collagen fibril organization|extracellular matrix|keratan sulfate catabolic process|lysosomal lumen|collagen-containing extracellular matrix hsa04350 TGF-beta signaling pathway FMR1 1247.578089 1198.556793 1296.599385 1.081800539 0.113434522 0.64033412 1 14.40323647 15.32069487 2332 FMRP translational regulator 1 "GO:0000381,GO:0000775,GO:0001934,GO:0002092,GO:0002151,GO:0003682,GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0005829,GO:0005844,GO:0005845,GO:0006397,GO:0006974,GO:0007215,GO:0007399,GO:0008017,GO:0008266,GO:0008380,GO:0010369,GO:0010494,GO:0014069,GO:0015030,GO:0016020,GO:0016032,GO:0017148,GO:0019897,GO:0030371,GO:0030424,GO:0030425,GO:0030426,GO:0031047,GO:0031369,GO:0032433,GO:0032797,GO:0033129,GO:0033592,GO:0034046,GO:0034644,GO:0035064,GO:0035197,GO:0035198,GO:0035613,GO:0036464,GO:0042734,GO:0042788,GO:0042802,GO:0042803,GO:0042995,GO:0043005,GO:0043022,GO:0043025,GO:0043197,GO:0043204,GO:0043488,GO:0043679,GO:0044325,GO:0044326,GO:0044830,GO:0045182,GO:0045202,GO:0045211,GO:0045727,GO:0045947,GO:0046928,GO:0046982,GO:0048027,GO:0048471,GO:0051028,GO:0051489,GO:0051491,GO:0060964,GO:0060998,GO:0060999,GO:0070840,GO:0071598,GO:0072711,GO:0097386,GO:0098586,GO:0098793,GO:0098794,GO:0098908,GO:1900453,GO:1901254,GO:1901386,GO:1901800,GO:1902373,GO:1902416,GO:1902737,GO:1990124,GO:1990812,GO:1990825,GO:1990904,GO:2000301,GO:2000637,GO:2000766,GO:2001022" "regulation of alternative mRNA splicing, via spliceosome|chromosome, centromeric region|positive regulation of protein phosphorylation|positive regulation of receptor internalization|G-quadruplex RNA binding|chromatin binding|RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|cytoplasm|cytosol|polysome|mRNA cap binding complex|mRNA processing|cellular response to DNA damage stimulus|glutamate receptor signaling pathway|nervous system development|microtubule binding|poly(U) RNA binding|RNA splicing|chromocenter|cytoplasmic stress granule|postsynaptic density|Cajal body|membrane|viral process|negative regulation of translation|extrinsic component of plasma membrane|translation repressor activity|axon|dendrite|growth cone|gene silencing by RNA|translation initiation factor binding|filopodium tip|SMN complex|positive regulation of histone phosphorylation|RNA strand annealing activity|poly(G) binding|cellular response to UV|methylated histone binding|siRNA binding|miRNA binding|RNA stem-loop binding|cytoplasmic ribonucleoprotein granule|presynaptic membrane|polysomal ribosome|identical protein binding|protein homodimerization activity|cell projection|neuron projection|ribosome binding|neuronal cell body|dendritic spine|perikaryon|regulation of mRNA stability|axon terminus|ion channel binding|dendritic spine neck|modulation by host of viral RNA genome replication|translation regulator activity|synapse|postsynaptic membrane|positive regulation of translation|negative regulation of translational initiation|regulation of neurotransmitter secretion|protein heterodimerization activity|mRNA 5'-UTR binding|perinuclear region of cytoplasm|mRNA transport|regulation of filopodium assembly|positive regulation of filopodium assembly|regulation of gene silencing by miRNA|regulation of dendritic spine development|positive regulation of dendritic spine development|dynein complex binding|neuronal ribonucleoprotein granule|cellular response to hydroxyurea|glial cell projection|cellular response to virus|presynapse|postsynapse|regulation of neuronal action potential|negative regulation of long-term synaptic depression|positive regulation of intracellular transport of viral material|negative regulation of voltage-gated calcium channel activity|positive regulation of proteasomal protein catabolic process|negative regulation of mRNA catabolic process|positive regulation of mRNA binding|dendritic filopodium|messenger ribonucleoprotein complex|growth cone filopodium|sequence-specific mRNA binding|ribonucleoprotein complex|negative regulation of synaptic vesicle exocytosis|positive regulation of gene silencing by miRNA|negative regulation of cytoplasmic translation|positive regulation of response to DNA damage stimulus" hsa03013 RNA transport FN1 149582.3517 214263.8754 84900.8279 0.396244247 -1.335538107 0.002770564 0.345392232 1315.562498 512.5610879 2335 fibronectin 1 "GO:0001525,GO:0001932,GO:0002020,GO:0002576,GO:0005102,GO:0005178,GO:0005201,GO:0005515,GO:0005518,GO:0005576,GO:0005577,GO:0005604,GO:0005615,GO:0005788,GO:0005793,GO:0006953,GO:0007044,GO:0007155,GO:0007160,GO:0007161,GO:0007229,GO:0007399,GO:0007507,GO:0008022,GO:0008201,GO:0008284,GO:0008360,GO:0009611,GO:0010628,GO:0010952,GO:0014068,GO:0016324,GO:0016504,GO:0018149,GO:0019221,GO:0019899,GO:0030198,GO:0031012,GO:0031093,GO:0033622,GO:0034446,GO:0035987,GO:0042802,GO:0043394,GO:0043687,GO:0044267,GO:0045773,GO:0048146,GO:0050900,GO:0051087,GO:0051702,GO:0062023,GO:0070062,GO:0070372,GO:0070527,GO:0071635,GO:0072378,GO:0072562,GO:0097718,GO:1901166,GO:1904237" "angiogenesis|regulation of protein phosphorylation|protease binding|platelet degranulation|signaling receptor binding|integrin binding|extracellular matrix structural constituent|protein binding|collagen binding|extracellular region|fibrinogen complex|basement membrane|extracellular space|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|acute-phase response|cell-substrate junction assembly|cell adhesion|cell-matrix adhesion|calcium-independent cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development|heart development|protein C-terminus binding|heparin binding|positive regulation of cell population proliferation|regulation of cell shape|response to wounding|positive regulation of gene expression|positive regulation of peptidase activity|positive regulation of phosphatidylinositol 3-kinase signaling|apical plasma membrane|peptidase activator activity|peptide cross-linking|cytokine-mediated signaling pathway|enzyme binding|extracellular matrix organization|extracellular matrix|platelet alpha granule lumen|integrin activation|substrate adhesion-dependent cell spreading|endodermal cell differentiation|identical protein binding|proteoglycan binding|post-translational protein modification|cellular protein metabolic process|positive regulation of axon extension|positive regulation of fibroblast proliferation|leukocyte migration|chaperone binding|biological process involved in interaction with symbiont|collagen-containing extracellular matrix|extracellular exosome|regulation of ERK1 and ERK2 cascade|platelet aggregation|negative regulation of transforming growth factor beta production|blood coagulation, fibrin clot formation|blood microparticle|disordered domain specific binding|neural crest cell migration involved in autonomic nervous system development|positive regulation of substrate-dependent cell migration, cell attachment to substrate" "hsa04151,hsa04510,hsa04512,hsa04810,hsa04933,hsa05100,hsa05135,hsa05146,hsa05165,hsa05200,hsa05205,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|AGE-RAGE signaling pathway in diabetic complications|Bacterial invasion of epithelial cells|Yersinia infection|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Small cell lung cancer FN3K 223.7002744 220.5677431 226.8328056 1.028404255 0.040407485 0.921165052 1 6.561479969 6.634937724 64122 fructosamine 3 kinase "GO:0005524,GO:0005575,GO:0005829,GO:0016301,GO:0016310,GO:0018215,GO:0030387,GO:0030389,GO:0030393,GO:0030855,GO:0036525,GO:0043687,GO:0102193,GO:0102194" ATP binding|cellular_component|cytosol|kinase activity|phosphorylation|protein phosphopantetheinylation|fructosamine-3-kinase activity|fructosamine metabolic process|fructoselysine metabolic process|epithelial cell differentiation|protein deglycation|post-translational protein modification|protein-ribulosamine 3-kinase activity|protein-fructosamine 3-kinase activity FN3KRP 1285.662636 1201.678034 1369.647237 1.139778874 0.188753958 0.434061557 1 30.93649209 34.67071906 79672 fructosamine 3 kinase related protein "GO:0005524,GO:0005829,GO:0016301,GO:0016310,GO:0018215,GO:0043687,GO:0102193" ATP binding|cytosol|kinase activity|phosphorylation|protein phosphopantetheinylation|post-translational protein modification|protein-ribulosamine 3-kinase activity FNBP1 1113.358439 1144.455271 1082.261606 0.945656535 -0.080611806 0.743421302 1 9.304916878 8.652011834 23048 formin binding protein 1 "GO:0005515,GO:0005764,GO:0005829,GO:0005856,GO:0005886,GO:0005905,GO:0005938,GO:0006897,GO:0007165,GO:0008289,GO:0031410,GO:0042802,GO:0043231,GO:0061024" protein binding|lysosome|cytosol|cytoskeleton|plasma membrane|clathrin-coated pit|cell cortex|endocytosis|signal transduction|lipid binding|cytoplasmic vesicle|identical protein binding|intracellular membrane-bounded organelle|membrane organization hsa05131 Shigellosis FNBP1L 1765.538083 1851.936711 1679.139455 0.906693757 -0.141312743 0.55227823 1 19.93434017 17.77189216 54874 formin binding protein 1 like "GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0006900,GO:0006914,GO:0007165,GO:0008289,GO:0010324,GO:0016050,GO:0030050,GO:0031410,GO:0045296,GO:0051020,GO:0051491,GO:0060271,GO:0061024,GO:0072583,GO:0097320" protein binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|cell cortex|vesicle budding from membrane|autophagy|signal transduction|lipid binding|membrane invagination|vesicle organization|vesicle transport along actin filament|cytoplasmic vesicle|cadherin binding|GTPase binding|positive regulation of filopodium assembly|cilium assembly|membrane organization|clathrin-dependent endocytosis|plasma membrane tubulation hsa05131 Shigellosis FNBP4 1781.962023 1841.532572 1722.391473 0.93530329 -0.096493833 0.685541355 1 16.95931127 15.59666886 23360 formin binding protein 4 "GO:0005515,GO:0016607" protein binding|nuclear speck FNDC10 75.73759174 83.23311061 68.24207288 0.819890935 -0.286496085 0.592047059 1 2.091336223 1.685974971 643988 fibronectin type III domain containing 10 GO:0016021 integral component of membrane FNDC11 70.86261487 56.18234966 85.54288008 1.522593494 0.606530819 0.254011981 1 1.479935214 2.215633139 79025 fibronectin type III domain containing 11 GO:0005515 protein binding FNDC3A 1856.768641 1849.855883 1863.681399 1.007473834 0.010742369 0.96634405 1 11.94764717 11.83551998 22862 fibronectin type III domain containing 3A "GO:0000139,GO:0003723,GO:0005794,GO:0016020,GO:0016021" Golgi membrane|RNA binding|Golgi apparatus|membrane|integral component of membrane FNDC3B 2435.592233 2725.884373 2145.300094 0.787010673 -0.345544895 0.143807624 1 12.54855853 9.710590521 64778 fibronectin type III domain containing 3B "GO:0003723,GO:0016021" RNA binding|integral component of membrane FNDC4 349.5318323 319.407062 379.6566026 1.188629332 0.249298888 0.409342434 1 10.57454581 12.35888653 64838 fibronectin type III domain containing 4 "GO:0005576,GO:0005615,GO:0005783,GO:0005886,GO:0016021,GO:0050728,GO:0071559" extracellular region|extracellular space|endoplasmic reticulum|plasma membrane|integral component of membrane|negative regulation of inflammatory response|response to transforming growth factor beta FNDC5 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.019002388 0.051783134 252995 fibronectin type III domain containing 5 "GO:0003674,GO:0005179,GO:0005576,GO:0005778,GO:0005783,GO:0005886,GO:0007165,GO:0008150,GO:0014850,GO:0016021,GO:0090336" molecular_function|hormone activity|extracellular region|peroxisomal membrane|endoplasmic reticulum|plasma membrane|signal transduction|biological_process|response to muscle activity|integral component of membrane|positive regulation of brown fat cell differentiation FNIP1 935.7338996 972.7869803 898.6808189 0.923820772 -0.11431511 0.646533737 1 7.770671042 7.058581374 96459 folliculin interacting protein 1 "GO:0000122,GO:0001932,GO:0001934,GO:0002327,GO:0002904,GO:0005085,GO:0005515,GO:0005737,GO:0005765,GO:0005829,GO:0009267,GO:0010823,GO:0019899,GO:0031334,GO:0031929,GO:0032007,GO:0032008,GO:0033138,GO:0042030,GO:0043154,GO:0051087,GO:1904262,GO:2000973" negative regulation of transcription by RNA polymerase II|regulation of protein phosphorylation|positive regulation of protein phosphorylation|immature B cell differentiation|positive regulation of B cell apoptotic process|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|lysosomal membrane|cytosol|cellular response to starvation|negative regulation of mitochondrion organization|enzyme binding|positive regulation of protein-containing complex assembly|TOR signaling|negative regulation of TOR signaling|positive regulation of TOR signaling|positive regulation of peptidyl-serine phosphorylation|ATPase inhibitor activity|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|chaperone binding|negative regulation of TORC1 signaling|regulation of pro-B cell differentiation hsa04150 mTOR signaling pathway FNIP2 318.6704317 379.7510672 257.5897962 0.678312238 -0.559978573 0.069550648 1 1.628233028 1.085968908 57600 folliculin interacting protein 2 "GO:0000122,GO:0001932,GO:0005515,GO:0005737,GO:0005765,GO:0005829,GO:0006468,GO:0008630,GO:0031334,GO:0033138,GO:0034451,GO:0042030,GO:0043086,GO:0051087" negative regulation of transcription by RNA polymerase II|regulation of protein phosphorylation|protein binding|cytoplasm|lysosomal membrane|cytosol|protein phosphorylation|intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of protein-containing complex assembly|positive regulation of peptidyl-serine phosphorylation|centriolar satellite|ATPase inhibitor activity|negative regulation of catalytic activity|chaperone binding hsa04150 mTOR signaling pathway FNTA 886.7105298 884.3518002 889.0692593 1.005334369 0.007675414 0.980499913 1 28.31207571 27.9868113 2339 "farnesyltransferase, CAAX box, alpha" "GO:0004660,GO:0004661,GO:0004662,GO:0004663,GO:0005515,GO:0005737,GO:0005829,GO:0005875,GO:0005886,GO:0005953,GO:0005965,GO:0007179,GO:0008017,GO:0018215,GO:0018343,GO:0018344,GO:0022400,GO:0030548,GO:0030971,GO:0043014,GO:0045213,GO:0071340,GO:0090044,GO:0090045,GO:0099601" protein farnesyltransferase activity|protein geranylgeranyltransferase activity|CAAX-protein geranylgeranyltransferase activity|Rab geranylgeranyltransferase activity|protein binding|cytoplasm|cytosol|microtubule associated complex|plasma membrane|CAAX-protein geranylgeranyltransferase complex|protein farnesyltransferase complex|transforming growth factor beta receptor signaling pathway|microtubule binding|protein phosphopantetheinylation|protein farnesylation|protein geranylgeranylation|regulation of rhodopsin mediated signaling pathway|acetylcholine receptor regulator activity|receptor tyrosine kinase binding|alpha-tubulin binding|neurotransmitter receptor metabolic process|skeletal muscle acetylcholine-gated channel clustering|positive regulation of tubulin deacetylation|positive regulation of deacetylase activity|regulation of neurotransmitter receptor activity hsa00900 Terpenoid backbone biosynthesis FNTB 7.084752362 9.363724944 4.80577978 0.513233762 -0.962312016 0.521952192 1 0.184332272 0.09302245 2342 "farnesyltransferase, CAAX box, beta" "GO:0004660,GO:0005515,GO:0005829,GO:0005875,GO:0005965,GO:0008270,GO:0018215,GO:0018342,GO:0018343,GO:0022400" protein farnesyltransferase activity|protein binding|cytosol|microtubule associated complex|protein farnesyltransferase complex|zinc ion binding|protein phosphopantetheinylation|protein prenylation|protein farnesylation|regulation of rhodopsin mediated signaling pathway hsa00900 Terpenoid backbone biosynthesis FOCAD 1084.905573 1091.394163 1078.416983 0.988109539 -0.017257112 0.947697212 1 7.622785051 7.406106346 54914 focadhesin "GO:0005515,GO:0005925,GO:0016021" protein binding|focal adhesion|integral component of membrane FOLR1 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.156555385 0 2348 folate receptor alpha "GO:0000139,GO:0001947,GO:0003147,GO:0003253,GO:0005515,GO:0005542,GO:0005634,GO:0005768,GO:0005789,GO:0005886,GO:0006888,GO:0006898,GO:0007155,GO:0007342,GO:0009986,GO:0012507,GO:0015884,GO:0016020,GO:0016323,GO:0016324,GO:0017015,GO:0030133,GO:0030136,GO:0031103,GO:0031362,GO:0031526,GO:0033116,GO:0035036,GO:0038023,GO:0046655,GO:0048208,GO:0051870,GO:0060828,GO:0061626,GO:0061713,GO:0061714,GO:0070062,GO:0071231,GO:1904447" Golgi membrane|heart looping|neural crest cell migration involved in heart formation|cardiac neural crest cell migration involved in outflow tract morphogenesis|protein binding|folic acid binding|nucleus|endosome|endoplasmic reticulum membrane|plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|receptor-mediated endocytosis|cell adhesion|fusion of sperm to egg plasma membrane involved in single fertilization|cell surface|ER to Golgi transport vesicle membrane|folic acid transport|membrane|basolateral plasma membrane|apical plasma membrane|regulation of transforming growth factor beta receptor signaling pathway|transport vesicle|clathrin-coated vesicle|axon regeneration|anchored component of external side of plasma membrane|brush border membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|sperm-egg recognition|signaling receptor activity|folic acid metabolic process|COPII vesicle coating|methotrexate binding|regulation of canonical Wnt signaling pathway|pharyngeal arch artery morphogenesis|anterior neural tube closure|folic acid receptor activity|extracellular exosome|cellular response to folic acid|folate import across plasma membrane "hsa01523,hsa04144" Antifolate resistance|Endocytosis FOLR3 6.807349619 2.080827765 11.53387147 5.54292463 2.470647391 0.104023039 1 0.113664231 0.619489527 2352 folate receptor gamma "GO:0005515,GO:0005542,GO:0005576,GO:0007155,GO:0007342,GO:0015884,GO:0016020,GO:0019898,GO:0031362,GO:0035036,GO:0035580,GO:0038023,GO:0043312,GO:1904724" protein binding|folic acid binding|extracellular region|cell adhesion|fusion of sperm to egg plasma membrane involved in single fertilization|folic acid transport|membrane|extrinsic component of membrane|anchored component of external side of plasma membrane|sperm-egg recognition|specific granule lumen|signaling receptor activity|neutrophil degranulation|tertiary granule lumen "hsa01523,hsa04144" Antifolate resistance|Endocytosis FOS 80.30559774 76.99062732 83.62056817 1.08611361 0.11917502 0.836282358 1 1.952874656 2.085550948 2353 "Fos proto-oncogene, AP-1 transcription factor subunit" "GO:0000785,GO:0000976,GO:0000978,GO:0000979,GO:0000981,GO:0001102,GO:0001228,GO:0001661,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005783,GO:0005829,GO:0006306,GO:0006357,GO:0006366,GO:0006954,GO:0007179,GO:0007399,GO:0007565,GO:0007568,GO:0008134,GO:0009409,GO:0009416,GO:0009629,GO:0009636,GO:0016020,GO:0019221,GO:0030431,GO:0031668,GO:0032496,GO:0032570,GO:0032870,GO:0032993,GO:0034614,GO:0035902,GO:0035914,GO:0035976,GO:0035994,GO:0038095,GO:0042493,GO:0043005,GO:0044877,GO:0045672,GO:0045893,GO:0045944,GO:0051090,GO:0051412,GO:0051591,GO:0060395,GO:0070412,GO:0071276,GO:0071277,GO:1901216,GO:1902895,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II activating transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|conditioned taste aversion|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|endoplasmic reticulum|cytosol|DNA methylation|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|inflammatory response|transforming growth factor beta receptor signaling pathway|nervous system development|female pregnancy|aging|transcription factor binding|response to cold|response to light stimulus|response to gravity|response to toxic substance|membrane|cytokine-mediated signaling pathway|sleep|cellular response to extracellular stimulus|response to lipopolysaccharide|response to progesterone|cellular response to hormone stimulus|protein-DNA complex|cellular response to reactive oxygen species|response to immobilization stress|skeletal muscle cell differentiation|transcription factor AP-1 complex|response to muscle stretch|Fc-epsilon receptor signaling pathway|response to drug|neuron projection|protein-containing complex binding|positive regulation of osteoclast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of DNA-binding transcription factor activity|response to corticosterone|response to cAMP|SMAD protein signal transduction|R-SMAD binding|cellular response to cadmium ion|cellular response to calcium ion|positive regulation of neuron death|positive regulation of pri-miRNA transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" "hsa01522,hsa04010,hsa04024,hsa04210,hsa04380,hsa04620,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04713,hsa04725,hsa04728,hsa04915,hsa04917,hsa04921,hsa04926,hsa04928,hsa04932,hsa04935,hsa05031,hsa05130,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05161,hsa05162,hsa05166,hsa05167,hsa05170,hsa05171,hsa05200,hsa05210,hsa05224,hsa05231,hsa05235,hsa05323,hsa05418" "Endocrine resistance|MAPK signaling pathway|cAMP signaling pathway|Apoptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Circadian entrainment|Cholinergic synapse|Dopaminergic synapse|Estrogen signaling pathway|Prolactin signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Non-alcoholic fatty liver disease|Growth hormone synthesis, secretion and action|Amphetamine addiction|Pathogenic Escherichia coli infection|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Hepatitis B|Measles|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Colorectal cancer|Breast cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Rheumatoid arthritis|Fluid shear stress and atherosclerosis" TF_bZIP FOSB 817.091504 822.9673812 811.2156269 0.985720267 -0.020749806 0.939308583 1 11.63450506 11.27645983 2354 "FosB proto-oncogene, AP-1 transcription factor subunit" "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006366,GO:0007565,GO:0008134,GO:0009612,GO:0032570,GO:0032870,GO:0042493,GO:0043231,GO:0043278,GO:0045944,GO:0051412,GO:0051591,GO:0071277,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|female pregnancy|transcription factor binding|response to mechanical stimulus|response to progesterone|cellular response to hormone stimulus|response to drug|intracellular membrane-bounded organelle|response to morphine|positive regulation of transcription by RNA polymerase II|response to corticosterone|response to cAMP|cellular response to calcium ion|sequence-specific double-stranded DNA binding" "hsa04380,hsa04657,hsa05030,hsa05031,hsa05034" Osteoclast differentiation|IL-17 signaling pathway|Cocaine addiction|Amphetamine addiction|Alcoholism FOSL1 12446.59323 11370.68332 13522.50314 1.189242789 0.250043277 0.330454311 1 356.540817 416.9183022 8061 "FOS like 1, AP-1 transcription factor subunit" "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001701,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006935,GO:0006968,GO:0007296,GO:0007565,GO:0007612,GO:0008284,GO:0008285,GO:0009612,GO:0009615,GO:0009629,GO:0031668,GO:0032570,GO:0034097,GO:0042493,GO:0042542,GO:0042734,GO:0043005,GO:0043065,GO:0045787,GO:0051091,GO:0051412,GO:0051591,GO:0060674,GO:1902895,GO:1990837,GO:2000144" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|in utero embryonic development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|chemotaxis|cellular defense response|vitellogenesis|female pregnancy|learning|positive regulation of cell population proliferation|negative regulation of cell population proliferation|response to mechanical stimulus|response to virus|response to gravity|cellular response to extracellular stimulus|response to progesterone|response to cytokine|response to drug|response to hydrogen peroxide|presynaptic membrane|neuron projection|positive regulation of apoptotic process|positive regulation of cell cycle|positive regulation of DNA-binding transcription factor activity|response to corticosterone|response to cAMP|placenta blood vessel development|positive regulation of pri-miRNA transcription by RNA polymerase II|sequence-specific double-stranded DNA binding|positive regulation of DNA-templated transcription, initiation" "hsa04310,hsa04380,hsa04657,hsa05166" Wnt signaling pathway|Osteoclast differentiation|IL-17 signaling pathway|Human T-cell leukemia virus 1 infection TF_bZIP FOSL2 2283.0175 2505.316629 2060.71837 0.822538096 -0.281845596 0.233139802 1 15.2161311 12.30641174 2355 "FOS like 2, AP-1 transcription factor subunit" "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0003334,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008219,GO:0045944,GO:0048146" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|keratinocyte development|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cell death|positive regulation of transcription by RNA polymerase II|positive regulation of fibroblast proliferation" hsa04380 Osteoclast differentiation TF_bZIP FOXA1 260.6198759 331.8920286 189.3477233 0.570510006 -0.809675904 0.014303654 0.708244576 4.127818125 2.315554452 3169 forkhead box A1 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001650,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005902,GO:0006338,GO:0006357,GO:0007219,GO:0008134,GO:0009653,GO:0010719,GO:0019904,GO:0021904,GO:0030154,GO:0032355,GO:0033148,GO:0042445,GO:0042593,GO:0043065,GO:0045666,GO:0045880,GO:0045931,GO:0045944,GO:0048646,GO:0048665,GO:0051091,GO:0060441,GO:0060487,GO:0060528,GO:0060738,GO:0060740,GO:0060741,GO:0060743,GO:0061144,GO:0071542,GO:1902691,GO:1990837,GO:2000049" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|fibrillar center|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|microvillus|chromatin remodeling|regulation of transcription by RNA polymerase II|Notch signaling pathway|transcription factor binding|anatomical structure morphogenesis|negative regulation of epithelial to mesenchymal transition|protein domain specific binding|dorsal/ventral neural tube patterning|cell differentiation|response to estradiol|positive regulation of intracellular estrogen receptor signaling pathway|hormone metabolic process|glucose homeostasis|positive regulation of apoptotic process|positive regulation of neuron differentiation|positive regulation of smoothened signaling pathway|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|anatomical structure formation involved in morphogenesis|neuron fate specification|positive regulation of DNA-binding transcription factor activity|epithelial tube branching involved in lung morphogenesis|lung epithelial cell differentiation|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development|epithelial-mesenchymal signaling involved in prostate gland development|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|epithelial cell maturation involved in prostate gland development|alveolar secondary septum development|dopaminergic neuron differentiation|respiratory basal cell differentiation|sequence-specific double-stranded DNA binding|positive regulation of cell-cell adhesion mediated by cadherin" chromosome_remodelling_factor FOXA2 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.060484724 0 3170 forkhead box A2 "GO:0000432,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001708,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006325,GO:0006357,GO:0008134,GO:0008344,GO:0009653,GO:0010719,GO:0019904,GO:0030054,GO:0030154,GO:0030193,GO:0031018,GO:0033132,GO:0040019,GO:0043433,GO:0045893,GO:0045944,GO:0061178,GO:0061987,GO:0070741,GO:0071542,GO:0090009,GO:1990837,GO:2000049,GO:2000543,GO:2000971" "positive regulation of transcription from RNA polymerase II promoter by glucose|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cell fate specification|DNA binding|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|chromatin organization|regulation of transcription by RNA polymerase II|transcription factor binding|adult locomotory behavior|anatomical structure morphogenesis|negative regulation of epithelial to mesenchymal transition|protein domain specific binding|cell junction|cell differentiation|regulation of blood coagulation|endocrine pancreas development|negative regulation of glucokinase activity|positive regulation of embryonic development|negative regulation of DNA-binding transcription factor activity|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of transcription from RNA polymerase II promoter by glucose|response to interleukin-6|dopaminergic neuron differentiation|primitive streak formation|sequence-specific double-stranded DNA binding|positive regulation of cell-cell adhesion mediated by cadherin|positive regulation of gastrulation|negative regulation of detection of glucose" "hsa04213,hsa04950" Longevity regulating pathway - multiple species|Maturity onset diabetes of the young Fork_head FOXC1 282.0974299 302.7604398 261.43442 0.863502577 -0.211727612 0.515336698 1 4.056682959 3.444338961 2296 forkhead box C1 "GO:0000122,GO:0000785,GO:0000792,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001525,GO:0001541,GO:0001654,GO:0001657,GO:0001701,GO:0001756,GO:0001822,GO:0001945,GO:0001958,GO:0001974,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006357,GO:0007219,GO:0007507,GO:0008134,GO:0008283,GO:0008301,GO:0008354,GO:0009653,GO:0010718,GO:0014031,GO:0014032,GO:0016477,GO:0016525,GO:0021549,GO:0030154,GO:0030199,GO:0030203,GO:0032808,GO:0035050,GO:0036438,GO:0038084,GO:0042475,GO:0043010,GO:0043388,GO:0043565,GO:0045618,GO:0045893,GO:0045930,GO:0045944,GO:0046620,GO:0048010,GO:0048341,GO:0048844,GO:0055010,GO:0060038,GO:0070098,GO:0071364,GO:0072010,GO:0097746,GO:1901491,GO:1901534,GO:1902038,GO:1902257,GO:1904798,GO:1990841,GO:1990869" "negative regulation of transcription by RNA polymerase II|chromatin|heterochromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|ovarian follicle development|eye development|ureteric bud development|in utero embryonic development|somitogenesis|kidney development|lymph vessel development|endochondral ossification|blood vessel remodeling|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|Notch signaling pathway|heart development|transcription factor binding|cell population proliferation|DNA binding, bending|germ cell migration|anatomical structure morphogenesis|positive regulation of epithelial to mesenchymal transition|mesenchymal cell development|neural crest cell development|cell migration|negative regulation of angiogenesis|cerebellum development|cell differentiation|collagen fibril organization|glycosaminoglycan metabolic process|lacrimal gland development|embryonic heart tube development|maintenance of lens transparency|vascular endothelial growth factor signaling pathway|odontogenesis of dentin-containing tooth|camera-type eye development|positive regulation of DNA binding|sequence-specific DNA binding|positive regulation of keratinocyte differentiation|positive regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|regulation of organ growth|vascular endothelial growth factor receptor signaling pathway|paraxial mesoderm formation|artery morphogenesis|ventricular cardiac muscle tissue morphogenesis|cardiac muscle cell proliferation|chemokine-mediated signaling pathway|cellular response to epidermal growth factor stimulus|glomerular epithelium development|blood vessel diameter maintenance|negative regulation of lymphangiogenesis|positive regulation of hematopoietic progenitor cell differentiation|positive regulation of hematopoietic stem cell differentiation|negative regulation of apoptotic process involved in outflow tract morphogenesis|positive regulation of core promoter binding|promoter-specific chromatin binding|cellular response to chemokine" FOXC2 314.4993297 295.4775427 333.5211167 1.128752844 0.174729623 0.578525672 1 5.43761841 6.035020693 2303 forkhead box C2 "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001216,GO:0001228,GO:0001503,GO:0001569,GO:0001656,GO:0001657,GO:0001756,GO:0001946,GO:0001974,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007219,GO:0007498,GO:0007507,GO:0008286,GO:0009653,GO:0009725,GO:0010595,GO:0014032,GO:0016604,GO:0030154,GO:0030199,GO:0031490,GO:0033630,GO:0035050,GO:0035470,GO:0042802,GO:0043010,GO:0043565,GO:0045893,GO:0045944,GO:0046620,GO:0048010,GO:0048343,GO:0048703,GO:0048844,GO:0055010,GO:0060038,GO:0072011,GO:0072112,GO:0072144,GO:0090050,GO:0097746,GO:0120163,GO:1902257,GO:1990837,GO:1990841" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity|DNA-binding transcription activator activity, RNA polymerase II-specific|ossification|branching involved in blood vessel morphogenesis|metanephros development|ureteric bud development|somitogenesis|lymphangiogenesis|blood vessel remodeling|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|Notch signaling pathway|mesoderm development|heart development|insulin receptor signaling pathway|anatomical structure morphogenesis|response to hormone|positive regulation of endothelial cell migration|neural crest cell development|nuclear body|cell differentiation|collagen fibril organization|chromatin DNA binding|positive regulation of cell adhesion mediated by integrin|embryonic heart tube development|positive regulation of vascular wound healing|identical protein binding|camera-type eye development|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of organ growth|vascular endothelial growth factor receptor signaling pathway|paraxial mesodermal cell fate commitment|embryonic viscerocranium morphogenesis|artery morphogenesis|ventricular cardiac muscle tissue morphogenesis|cardiac muscle cell proliferation|glomerular endothelium development|glomerular visceral epithelial cell differentiation|glomerular mesangial cell development|positive regulation of cell migration involved in sprouting angiogenesis|blood vessel diameter maintenance|negative regulation of cold-induced thermogenesis|negative regulation of apoptotic process involved in outflow tract morphogenesis|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding" FOXD1 1012.151443 859.3818671 1164.921019 1.355533626 0.438860902 0.073970288 1 18.2578148 24.33493953 2297 forkhead box D1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0005634,GO:0006357,GO:0007411,GO:0008301,GO:0009653,GO:0010628,GO:0030154,GO:0030513,GO:0032275,GO:0043565,GO:0045892,GO:0045944,GO:0060678,GO:0072076,GO:0072210,GO:0072213,GO:0072267,GO:0090184" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|axon guidance|DNA binding, bending|anatomical structure morphogenesis|positive regulation of gene expression|cell differentiation|positive regulation of BMP signaling pathway|luteinizing hormone secretion|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|dichotomous subdivision of terminal units involved in ureteric bud branching|nephrogenic mesenchyme development|metanephric nephron development|metanephric capsule development|metanephric capsule specification|positive regulation of kidney development" FOXD2 22.78027936 17.687036 27.87352272 1.575929552 0.656203044 0.433950845 1 0.356466996 0.552366465 2306 forkhead box D2 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0009653,GO:0030154,GO:0043565,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|cell differentiation|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" Fork_head FOXD4 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.076165949 0.046124163 2298 forkhead box D4 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0008301,GO:0009653,GO:0030154,GO:0043565" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|DNA binding, bending|anatomical structure morphogenesis|cell differentiation|sequence-specific DNA binding" FOXF1 280.7003554 291.3158871 270.0848236 0.927120132 -0.109171807 0.743511075 1 4.416759512 4.026344612 2294 forkhead box F1 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001568,GO:0001570,GO:0001701,GO:0001756,GO:0001763,GO:0002053,GO:0003197,GO:0003214,GO:0003677,GO:0005634,GO:0005667,GO:0006357,GO:0007224,GO:0007368,GO:0007494,GO:0007507,GO:0009887,GO:0010811,GO:0014822,GO:0030198,GO:0030323,GO:0030324,GO:0030335,GO:0031016,GO:0043305,GO:0043565,GO:0045198,GO:0045893,GO:0045944,GO:0048286,GO:0048371,GO:0048557,GO:0048565,GO:0048613,GO:0048617,GO:0050728,GO:0051145,GO:0060426,GO:0060438,GO:0060441,GO:0060461,GO:0060463,GO:0060841,GO:0061030,GO:0071345,GO:0071407,GO:0072189,GO:0090131,GO:0097070,GO:0098609" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|blood vessel development|vasculogenesis|in utero embryonic development|somitogenesis|morphogenesis of a branching structure|positive regulation of mesenchymal cell proliferation|endocardial cushion development|cardiac left ventricle morphogenesis|DNA binding|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|smoothened signaling pathway|determination of left/right symmetry|midgut development|heart development|animal organ morphogenesis|positive regulation of cell-substrate adhesion|detection of wounding|extracellular matrix organization|respiratory tube development|lung development|positive regulation of cell migration|pancreas development|negative regulation of mast cell degranulation|sequence-specific DNA binding|establishment of epithelial cell apical/basal polarity|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|lung alveolus development|lateral mesodermal cell differentiation|embryonic digestive tract morphogenesis|digestive tract development|embryonic ectodermal digestive tract morphogenesis|embryonic foregut morphogenesis|negative regulation of inflammatory response|smooth muscle cell differentiation|lung vasculature development|trachea development|epithelial tube branching involved in lung morphogenesis|right lung morphogenesis|lung lobe morphogenesis|venous blood vessel development|epithelial cell differentiation involved in mammary gland alveolus development|cellular response to cytokine stimulus|cellular response to organic cyclic compound|ureter development|mesenchyme migration|ductus arteriosus closure|cell-cell adhesion" FOXF2 241.2684235 252.8205735 229.7162735 0.908613845 -0.138260806 0.691968009 1 5.504924252 4.918151201 2295 forkhead box F2 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001837,GO:0003677,GO:0003700,GO:0005634,GO:0005667,GO:0006357,GO:0008134,GO:0009887,GO:0030198,GO:0032434,GO:0042249,GO:0043565,GO:0045892,GO:0045893,GO:0045944,GO:0048566,GO:0048596,GO:0048806,GO:0060021,GO:1902914" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|epithelial to mesenchymal transition|DNA binding|DNA-binding transcription factor activity|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription factor binding|animal organ morphogenesis|extracellular matrix organization|regulation of proteasomal ubiquitin-dependent protein catabolic process|establishment of planar polarity of embryonic epithelium|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|embryonic digestive tract development|embryonic camera-type eye morphogenesis|genitalia development|roof of mouth development|regulation of protein polyubiquitination" FOXG1 6.683432311 11.44455271 1.922311912 0.167967413 -2.573746729 0.09106035 1 0.174956959 0.028895315 2290 forkhead box G1 "GO:0000122,GO:0000785,GO:0000981,GO:0002052,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007346,GO:0007420,GO:0007568,GO:0009953,GO:0016199,GO:0021852,GO:0042472,GO:0045665,GO:0045666,GO:0045787,GO:0045892,GO:0048664,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|positive regulation of neuroblast proliferation|DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|regulation of mitotic cell cycle|brain development|aging|dorsal/ventral pattern formation|axon midline choice point recognition|pyramidal neuron migration|inner ear morphogenesis|negative regulation of neuron differentiation|positive regulation of neuron differentiation|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|neuron fate determination|sequence-specific double-stranded DNA binding" hsa04068 FoxO signaling pathway Fork_head FOXH1 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.082585488 0.025005837 8928 forkhead box H1 "GO:0000122,GO:0000785,GO:0000976,GO:0000981,GO:0000987,GO:0001228,GO:0001947,GO:0003139,GO:0003151,GO:0003215,GO:0003222,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0007179,GO:0019904,GO:0032444,GO:0033147,GO:0035054,GO:0035909,GO:0043425,GO:0043433,GO:0043565,GO:0045893,GO:0045944,GO:0046332,GO:0048318,GO:0050681,GO:0060766,GO:0070410,GO:0070412,GO:0071345,GO:1900164" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|heart looping|secondary heart field specification|outflow tract morphogenesis|cardiac right ventricle morphogenesis|ventricular trabecula myocardium morphogenesis|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|transforming growth factor beta receptor signaling pathway|protein domain specific binding|activin responsive factor complex|negative regulation of intracellular estrogen receptor signaling pathway|embryonic heart tube anterior/posterior pattern specification|aorta morphogenesis|bHLH transcription factor binding|negative regulation of DNA-binding transcription factor activity|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|SMAD binding|axial mesoderm development|androgen receptor binding|negative regulation of androgen receptor signaling pathway|co-SMAD binding|R-SMAD binding|cellular response to cytokine stimulus|nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" Fork_head FOXJ2 1033.434039 1115.323682 951.5443964 0.853155377 -0.229119585 0.350447008 1 10.03418325 8.417465381 55810 forkhead box J2 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0016525,GO:0042802,GO:0045944,GO:0110059,GO:1904707,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|fibrillar center|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|negative regulation of angiogenesis|identical protein binding|positive regulation of transcription by RNA polymerase II|negative regulation of blood vessel endothelial cell differentiation|positive regulation of vascular associated smooth muscle cell proliferation|sequence-specific double-stranded DNA binding" FOXJ3 1531.636845 1603.277793 1459.995897 0.910631896 -0.135060102 0.572238226 1 13.96735049 12.5062777 22887 forkhead box J3 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0043565,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" FOXK1 1738.408679 1694.834215 1781.983142 1.051420326 0.07233953 0.762341513 1 8.080238259 8.353562262 221937 forkhead box K1 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0001678,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007517,GO:0010507,GO:0010906,GO:0016032,GO:0016579,GO:0030154,GO:0042594,GO:0045892,GO:0045893,GO:0061621,GO:0071889,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|cellular glucose homeostasis|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|muscle organ development|negative regulation of autophagy|regulation of glucose metabolic process|viral process|protein deubiquitination|cell differentiation|response to starvation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|canonical glycolysis|14-3-3 protein binding|sequence-specific double-stranded DNA binding" Fork_head FOXK2 2475.421683 2572.943532 2377.899835 0.924194335 -0.113731849 0.631241348 1 26.18982785 23.79946115 3607 forkhead box K2 "GO:0000122,GO:0000287,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0001678,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006355,GO:0006357,GO:0010507,GO:0010906,GO:0016579,GO:0042594,GO:0043231,GO:0043565,GO:0045892,GO:0045893,GO:0045944,GO:0061621" "negative regulation of transcription by RNA polymerase II|magnesium ion binding|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|cellular glucose homeostasis|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|negative regulation of autophagy|regulation of glucose metabolic process|protein deubiquitination|response to starvation|intracellular membrane-bounded organelle|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|canonical glycolysis" FOXL1 655.0102352 441.1354862 868.8849842 1.969655608 0.977943398 0.000177073 0.056965773 4.775373251 9.248446697 2300 forkhead box L1 "GO:0000785,GO:0000978,GO:0000981,GO:0003677,GO:0003700,GO:0005634,GO:0006357,GO:0007275,GO:0007495,GO:0007507,GO:0008301,GO:0009653,GO:0030111,GO:0030154,GO:0030166,GO:0043565,GO:0061146" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|visceral mesoderm-endoderm interaction involved in midgut development|heart development|DNA binding, bending|anatomical structure morphogenesis|regulation of Wnt signaling pathway|cell differentiation|proteoglycan biosynthetic process|sequence-specific DNA binding|Peyer's patch morphogenesis" FOXL2 139.4361963 127.9709076 150.9014851 1.179185863 0.237791134 0.577155818 1 2.34371041 2.717423906 668 forkhead box L2 "GO:0000785,GO:0000978,GO:0000981,GO:0001541,GO:0002074,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006309,GO:0006357,GO:0009653,GO:0030154,GO:0031624,GO:0043028,GO:0043065,GO:0043280,GO:0045892,GO:0045893,GO:0090543,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|ovarian follicle development|extraocular skeletal muscle development|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|apoptotic DNA fragmentation|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|cell differentiation|ubiquitin conjugating enzyme binding|cysteine-type endopeptidase regulator activity involved in apoptotic process|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|Flemming body|sequence-specific double-stranded DNA binding" FOXL2NB 171.2977675 169.5874629 173.0080721 1.020170177 0.028809832 0.957093546 1 1.887501815 1.893351204 401089 FOXL2 neighbor GO:0001650 fibrillar center FOXM1 3299.682843 3293.950352 3305.415333 1.003480617 0.00501275 0.98457587 1 47.37054063 46.73997848 2305 forkhead box M1 "GO:0000086,GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006357,GO:0006978,GO:0008284,GO:0019901,GO:0032873,GO:0042127,GO:0045892,GO:0045893,GO:0045944,GO:0046578,GO:0051726,GO:0071156,GO:0090344,GO:2000377,GO:2000781" "G2/M transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|DNA repair|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|positive regulation of cell population proliferation|protein kinase binding|negative regulation of stress-activated MAPK cascade|regulation of cell population proliferation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of Ras protein signal transduction|regulation of cell cycle|regulation of cell cycle arrest|negative regulation of cell aging|regulation of reactive oxygen species metabolic process|positive regulation of double-strand break repair" hsa04218 Cellular senescence Fork_head FOXN2 595.5808835 634.6524684 556.5092985 0.876872503 -0.189561004 0.473744802 1 5.69056381 4.906399731 3344 forkhead box N2 "GO:0000785,GO:0000981,GO:0000987,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0035914,GO:0043231,GO:1990837" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|skeletal muscle cell differentiation|intracellular membrane-bounded organelle|sequence-specific double-stranded DNA binding" FOXN3 1393.77133 1453.458194 1334.084467 0.91786917 -0.123639563 0.607300971 1 9.430807596 8.511396965 1112 forkhead box N3 "GO:0000785,GO:0000981,GO:0000987,GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0007095,GO:0008022,GO:0045892,GO:0097094" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|mitotic G2 DNA damage checkpoint|protein C-terminus binding|negative regulation of transcription, DNA-templated|craniofacial suture morphogenesis" FOXO1 251.4196973 304.8412676 197.9981269 0.649512215 -0.622571437 0.06234716 1 1.530894719 0.977695973 2308 forkhead box O1 "GO:0000785,GO:0000978,GO:0000981,GO:0001223,GO:0001228,GO:0001659,GO:0001678,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006357,GO:0006473,GO:0006914,GO:0006915,GO:0006974,GO:0008013,GO:0008286,GO:0009267,GO:0010508,GO:0019221,GO:0031018,GO:0031625,GO:0032869,GO:0032873,GO:0034599,GO:0043065,GO:0043066,GO:0043565,GO:0045444,GO:0045599,GO:0045732,GO:0045892,GO:0045893,GO:0045944,GO:0051721,GO:0070166,GO:0070301,GO:0070417,GO:0070542,GO:0071455,GO:0071549,GO:0071732,GO:0097009,GO:1902617,GO:1903243" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|transcription coactivator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|temperature homeostasis|cellular glucose homeostasis|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|regulation of transcription by RNA polymerase II|protein acetylation|autophagy|apoptotic process|cellular response to DNA damage stimulus|beta-catenin binding|insulin receptor signaling pathway|cellular response to starvation|positive regulation of autophagy|cytokine-mediated signaling pathway|endocrine pancreas development|ubiquitin protein ligase binding|cellular response to insulin stimulus|negative regulation of stress-activated MAPK cascade|cellular response to oxidative stress|positive regulation of apoptotic process|negative regulation of apoptotic process|sequence-specific DNA binding|fat cell differentiation|negative regulation of fat cell differentiation|positive regulation of protein catabolic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein phosphatase 2A binding|enamel mineralization|cellular response to hydrogen peroxide|cellular response to cold|response to fatty acid|cellular response to hyperoxia|cellular response to dexamethasone stimulus|cellular response to nitric oxide|energy homeostasis|response to fluoride|negative regulation of cardiac muscle hypertrophy in response to stress" "hsa04068,hsa04152,hsa04211,hsa04213,hsa04218,hsa04910,hsa04919,hsa04922,hsa04931,hsa04933,hsa05131,hsa05165,hsa05200,hsa05202,hsa05215" FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Insulin signaling pathway|Thyroid hormone signaling pathway|Glucagon signaling pathway|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|Shigellosis|Human papillomavirus infection|Pathways in cancer|Transcriptional misregulation in cancer|Prostate cancer Fork_head FOXO3 762.716381 896.8367668 628.5959952 0.700903463 -0.512712344 0.042786721 1 3.281402025 2.261459559 2309 forkhead box O3 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005759,GO:0005829,GO:0006357,GO:0006390,GO:0006417,GO:0006915,GO:0008013,GO:0010508,GO:0014737,GO:0019221,GO:0019901,GO:0030336,GO:0031490,GO:0032991,GO:0033209,GO:0034246,GO:0034599,GO:0042149,GO:0042594,GO:0043065,GO:0043525,GO:0043565,GO:0045648,GO:0045893,GO:0045944,GO:0070542,GO:1902895,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial matrix|cytosol|regulation of transcription by RNA polymerase II|mitochondrial transcription|regulation of translation|apoptotic process|beta-catenin binding|positive regulation of autophagy|positive regulation of muscle atrophy|cytokine-mediated signaling pathway|protein kinase binding|negative regulation of cell migration|chromatin DNA binding|protein-containing complex|tumor necrosis factor-mediated signaling pathway|mitochondrial transcription factor activity|cellular response to oxidative stress|cellular response to glucose starvation|response to starvation|positive regulation of apoptotic process|positive regulation of neuron apoptotic process|sequence-specific DNA binding|positive regulation of erythrocyte differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|response to fatty acid|positive regulation of pri-miRNA transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" "hsa01521,hsa04062,hsa04068,hsa04137,hsa04151,hsa04152,hsa04211,hsa04213,hsa04218,hsa04722,hsa04917,hsa05131,hsa05213,hsa05223" EGFR tyrosine kinase inhibitor resistance|Chemokine signaling pathway|FoxO signaling pathway|Mitophagy - animal|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Neurotrophin signaling pathway|Prolactin signaling pathway|Shigellosis|Endometrial cancer|Non-small cell lung cancer Fork_head FOXO3B 124.5332486 140.4558742 108.610623 0.773272202 -0.370951745 0.396383873 1 1.260657897 0.958519219 2310 forkhead box O3B "GO:0003700,GO:0005829,GO:0006355,GO:0043565" "DNA-binding transcription factor activity|cytosol|regulation of transcription, DNA-templated|sequence-specific DNA binding" FOXO4 162.1271569 168.547049 155.7072649 0.923820772 -0.11431511 0.784728156 1 2.410248185 2.189377578 4303 forkhead box O4 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0007050,GO:0007095,GO:0007517,GO:0007568,GO:0008013,GO:0008134,GO:0008285,GO:0008286,GO:0014911,GO:0016525,GO:0016579,GO:0016607,GO:0019899,GO:0031667,GO:0042802,GO:0043565,GO:0045944,GO:0048863,GO:0051151,GO:0070317,GO:0071158,GO:1990785,GO:1990837,GO:1990841" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|cell cycle arrest|mitotic G2 DNA damage checkpoint|muscle organ development|aging|beta-catenin binding|transcription factor binding|negative regulation of cell population proliferation|insulin receptor signaling pathway|positive regulation of smooth muscle cell migration|negative regulation of angiogenesis|protein deubiquitination|nuclear speck|enzyme binding|response to nutrient levels|identical protein binding|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|stem cell differentiation|negative regulation of smooth muscle cell differentiation|negative regulation of G0 to G1 transition|positive regulation of cell cycle arrest|response to water-immersion restraint stress|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding" "hsa04014,hsa04068,hsa05131" Ras signaling pathway|FoxO signaling pathway|Shigellosis Fork_head FOXO6 11.85090318 8.323311061 15.3784953 1.847641543 0.88568489 0.430428857 1 0.15396874 0.279718668 100132074 forkhead box O6 "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0007613,GO:0060999" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|memory|positive regulation of dendritic spine development" "hsa04068,hsa05131" FoxO signaling pathway|Shigellosis FOXP1 789.5501043 793.8357925 785.264416 0.989202583 -0.015662089 0.955926585 1 3.150792595 3.064617211 27086 forkhead box P1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001046,GO:0001227,GO:0002903,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006974,GO:0010468,GO:0010595,GO:0010629,GO:0030316,GO:0032496,GO:0032625,GO:0032651,GO:0032655,GO:0032680,GO:0035019,GO:0036035,GO:0042116,GO:0042117,GO:0042118,GO:0042802,GO:0043621,GO:0045655,GO:0045892,GO:0046872,GO:0048661,GO:0050681,GO:0050727,GO:0050861,GO:0060766,GO:0061470,GO:1900424,GO:1901256,GO:1901509,GO:1990837,GO:2000341" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|core promoter sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|negative regulation of B cell apoptotic process|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|regulation of gene expression|positive regulation of endothelial cell migration|negative regulation of gene expression|osteoclast differentiation|response to lipopolysaccharide|interleukin-21 production|regulation of interleukin-1 beta production|regulation of interleukin-12 production|regulation of tumor necrosis factor production|somatic stem cell population maintenance|osteoclast development|macrophage activation|monocyte activation|endothelial cell activation|identical protein binding|protein self-association|regulation of monocyte differentiation|negative regulation of transcription, DNA-templated|metal ion binding|positive regulation of smooth muscle cell proliferation|androgen receptor binding|regulation of inflammatory response|positive regulation of B cell receptor signaling pathway|negative regulation of androgen receptor signaling pathway|T follicular helper cell differentiation|regulation of defense response to bacterium|regulation of macrophage colony-stimulating factor production|regulation of endothelial tube morphogenesis|sequence-specific double-stranded DNA binding|regulation of chemokine (C-X-C motif) ligand 2 production" hsa05206 MicroRNAs in cancer Fork_head FOXP2 75.70802362 57.22276355 94.19328369 1.646080648 0.719035021 0.164886875 1 0.392882249 0.635893952 93986 forkhead box P2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0021757,GO:0021758,GO:0021987,GO:0033574,GO:0042802,GO:0042803,GO:0043565,GO:0045892,GO:0046872,GO:0050681,GO:0098582" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|caudate nucleus development|putamen development|cerebral cortex development|response to testosterone|identical protein binding|protein homodimerization activity|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding|androgen receptor binding|innate vocalization behavior" Fork_head FOXP3 3.081612685 5.202069413 0.961155956 0.184764154 -2.436243205 0.338470402 1 0.109430384 0.019880478 50943 forkhead box P3 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001782,GO:0001818,GO:0002262,GO:0002362,GO:0002456,GO:0002513,GO:0002667,GO:0002669,GO:0002677,GO:0002725,GO:0002851,GO:0003677,GO:0003700,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006338,GO:0006355,GO:0006357,GO:0008285,GO:0009615,GO:0010467,GO:0030111,GO:0031064,GO:0032088,GO:0032496,GO:0032689,GO:0032693,GO:0032700,GO:0032703,GO:0032713,GO:0032714,GO:0032715,GO:0032720,GO:0032753,GO:0032792,GO:0032831,GO:0032914,GO:0032991,GO:0033092,GO:0035035,GO:0035066,GO:0035067,GO:0042110,GO:0042130,GO:0042803,GO:0042826,GO:0043029,GO:0043433,GO:0043565,GO:0045589,GO:0045892,GO:0045893,GO:0045944,GO:0046007,GO:0046872,GO:0048294,GO:0048302,GO:0050777,GO:0050852,GO:0051059,GO:0051525,GO:1990837,GO:2000320" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|B cell homeostasis|negative regulation of cytokine production|myeloid cell homeostasis|CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment|T cell mediated immunity|tolerance induction to self antigen|regulation of T cell anergy|positive regulation of T cell anergy|negative regulation of chronic inflammatory response|negative regulation of T cell cytokine production|positive regulation of peripheral T cell tolerance induction|DNA binding|DNA-binding transcription factor activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|chromatin remodeling|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|negative regulation of cell population proliferation|response to virus|gene expression|regulation of Wnt signaling pathway|negative regulation of histone deacetylation|negative regulation of NF-kappaB transcription factor activity|response to lipopolysaccharide|negative regulation of interferon-gamma production|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of interleukin-2 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|positive regulation of interleukin-4 production|negative regulation of CREB transcription factor activity|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|positive regulation of transforming growth factor beta1 production|protein-containing complex|positive regulation of immature T cell proliferation in thymus|histone acetyltransferase binding|positive regulation of histone acetylation|negative regulation of histone acetylation|T cell activation|negative regulation of T cell proliferation|protein homodimerization activity|histone deacetylase binding|T cell homeostasis|negative regulation of DNA-binding transcription factor activity|sequence-specific DNA binding|regulation of regulatory T cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of activated T cell proliferation|metal ion binding|negative regulation of isotype switching to IgE isotypes|regulation of isotype switching to IgG isotypes|negative regulation of immune response|T cell receptor signaling pathway|NF-kappaB binding|NFAT protein binding|sequence-specific double-stranded DNA binding|negative regulation of T-helper 17 cell differentiation" "hsa04659,hsa05321" Th17 cell differentiation|Inflammatory bowel disease chromosome_remodelling_factor FOXP4 464.0817694 487.954111 440.2094278 0.902153334 -0.148555434 0.59752768 1 4.426519477 3.926575173 116113 forkhead box P4 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" FOXQ1 98.03226271 113.4051132 82.65941222 0.728886113 -0.45623468 0.336219812 1 2.274416558 1.630049764 94234 forkhead box Q1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0009653,GO:0030154,GO:0031069,GO:0043524,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|cell differentiation|hair follicle morphogenesis|negative regulation of neuron apoptotic process|sequence-specific double-stranded DNA binding" FOXRED1 792.5077996 808.4015868 776.6140124 0.960678486 -0.057874416 0.822742474 1 11.38335275 10.75274725 55572 FAD dependent oxidoreductase domain containing 1 "GO:0005737,GO:0005739,GO:0005743,GO:0005747,GO:0016021,GO:0016491,GO:0032981,GO:0055114" cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|integral component of membrane|oxidoreductase activity|mitochondrial respiratory chain complex I assembly|oxidation-reduction process FOXRED2 771.8568091 972.7869803 570.9266379 0.586897902 -0.768818544 0.002412792 0.313463325 10.37694448 5.988295579 80020 FAD dependent oxidoreductase domain containing 2 "GO:0005515,GO:0005788,GO:0016491,GO:0030433,GO:0050660,GO:0055114" protein binding|endoplasmic reticulum lumen|oxidoreductase activity|ubiquitin-dependent ERAD pathway|flavin adenine dinucleotide binding|oxidation-reduction process FPGS 1496.515638 1501.317233 1491.714044 0.993603491 -0.009257852 0.972163478 1 27.65707332 27.02032127 2356 folylpolyglutamate synthase "GO:0001889,GO:0004326,GO:0005524,GO:0005737,GO:0005739,GO:0005743,GO:0005759,GO:0005829,GO:0006139,GO:0006536,GO:0006730,GO:0006760,GO:0007420,GO:0009396,GO:0031100,GO:0046655,GO:0046872,GO:0046901" liver development|tetrahydrofolylpolyglutamate synthase activity|ATP binding|cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|cytosol|nucleobase-containing compound metabolic process|glutamate metabolic process|one-carbon metabolic process|folic acid-containing compound metabolic process|brain development|folic acid-containing compound biosynthetic process|animal organ regeneration|folic acid metabolic process|metal ion binding|tetrahydrofolylpolyglutamate biosynthetic process "hsa00790,hsa01523" Folate biosynthesis|Antifolate resistance FPGT 217.6509055 225.7698125 209.5319984 0.92807801 -0.107682018 0.770344264 1 3.057325539 2.789955944 8790 fucose-1-phosphate guanylyltransferase "GO:0003824,GO:0005525,GO:0005737,GO:0005829,GO:0006004,GO:0047341" catalytic activity|GTP binding|cytoplasm|cytosol|fucose metabolic process|fucose-1-phosphate guanylyltransferase activity "hsa00051,hsa00520" Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism FRA10AC1 666.4881577 679.3902654 653.5860501 0.962018568 -0.055863355 0.833970899 1 9.692010103 9.167870945 118924 FRA10A associated CGG repeat 1 "GO:0005515,GO:0005634,GO:0016311,GO:0016791" protein binding|nucleus|dephosphorylation|phosphatase activity FRAS1 426.6061336 563.9043244 289.3079428 0.513044377 -0.962844475 0.000748142 0.165013495 1.792194937 0.904089357 80144 Fraser extracellular matrix complex subunit 1 "GO:0002009,GO:0003338,GO:0005201,GO:0005604,GO:0005886,GO:0007154,GO:0015031,GO:0016021,GO:0030326,GO:0043588,GO:0046872,GO:0060021,GO:0062023" morphogenesis of an epithelium|metanephros morphogenesis|extracellular matrix structural constituent|basement membrane|plasma membrane|cell communication|protein transport|integral component of membrane|embryonic limb morphogenesis|skin development|metal ion binding|roof of mouth development|collagen-containing extracellular matrix hsa04512 ECM-receptor interaction FRAT1 113.5246145 129.0113214 98.03790751 0.759917086 -0.396086078 0.380346139 1 2.60306129 1.945009747 10023 FRAT regulator of WNT signaling pathway 1 "GO:0005515,GO:0005737,GO:0005829,GO:0043231,GO:0060070,GO:0090263,GO:1904886" protein binding|cytoplasm|cytosol|intracellular membrane-bounded organelle|canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|beta-catenin destruction complex disassembly "hsa04310,hsa05010,hsa05022,hsa05200,hsa05224,hsa05225,hsa05226" Wnt signaling pathway|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Pathways in cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer FRAT2 265.3268905 278.8309205 251.8228605 0.903138217 -0.146981299 0.66179307 1 6.663991832 5.91779416 23401 FRAT regulator of WNT signaling pathway 2 "GO:0003674,GO:0005575,GO:0005737,GO:0005829,GO:1904886" molecular_function|cellular_component|cytoplasm|cytosol|beta-catenin destruction complex disassembly "hsa04310,hsa05010,hsa05022,hsa05200,hsa05224,hsa05225,hsa05226" Wnt signaling pathway|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Pathways in cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer FRG1 548.9956165 458.8225222 639.1687107 1.393063068 0.478260575 0.074026222 1 24.73385326 33.87924608 2483 FSHD region gene 1 "GO:0000398,GO:0003723,GO:0005515,GO:0005730,GO:0006364,GO:0007517,GO:0015030,GO:0030018,GO:0051015,GO:0055120,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleolus|rRNA processing|muscle organ development|Cajal body|Z disc|actin filament binding|striated muscle dense body|catalytic step 2 spliceosome" FRK 56.16787279 48.89945248 63.4362931 1.297280233 0.375490158 0.527087422 1 0.185900691 0.237129718 2444 fyn related Src family tyrosine kinase "GO:0000122,GO:0004713,GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005576,GO:0005622,GO:0005634,GO:0005654,GO:0005829,GO:0006468,GO:0007169,GO:0008285,GO:0030154,GO:0031234,GO:0035578,GO:0035580,GO:0038083,GO:0042127,GO:0043312,GO:0045087,GO:0070062" negative regulation of transcription by RNA polymerase II|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|protein binding|ATP binding|extracellular region|intracellular anatomical structure|nucleus|nucleoplasm|cytosol|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|negative regulation of cell population proliferation|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|azurophil granule lumen|specific granule lumen|peptidyl-tyrosine autophosphorylation|regulation of cell population proliferation|neutrophil degranulation|innate immune response|extracellular exosome FRMD3 674.5938167 639.8545378 709.3330955 1.108584926 0.148719296 0.566672393 1 3.001481997 3.271718204 257019 FERM domain containing 3 "GO:0005515,GO:0005856,GO:0008092,GO:0016021,GO:0031032" protein binding|cytoskeleton|cytoskeletal protein binding|integral component of membrane|actomyosin structure organization FRMD4A 1388.950459 1490.913094 1286.987825 0.863221224 -0.212197759 0.376331214 1 4.418686713 3.750476936 55691 FERM domain containing 4A "GO:0005737,GO:0005856,GO:0005912,GO:0005923,GO:0030674,GO:0050709,GO:0050714,GO:0090162" cytoplasm|cytoskeleton|adherens junction|bicellular tight junction|protein-macromolecule adaptor activity|negative regulation of protein secretion|positive regulation of protein secretion|establishment of epithelial cell polarity FRMD4B 3.562190663 5.202069413 1.922311912 0.369528309 -1.436243205 0.543489417 1 0.029698854 0.010790923 23150 FERM domain containing 4B "GO:0001726,GO:0005615,GO:0005737,GO:0005856,GO:0005912,GO:0005923,GO:0090162" ruffle|extracellular space|cytoplasm|cytoskeleton|adherens junction|bicellular tight junction|establishment of epithelial cell polarity FRMD5 157.9705318 147.7387713 168.2022923 1.138511514 0.187148882 0.648120303 1 1.433553944 1.604806393 84978 FERM domain containing 5 "GO:0005178,GO:0005515,GO:0005856,GO:0005912,GO:0008092,GO:0016021,GO:0019901,GO:0030334,GO:0031032,GO:0045785,GO:2000146" integrin binding|protein binding|cytoskeleton|adherens junction|cytoskeletal protein binding|integral component of membrane|protein kinase binding|regulation of cell migration|actomyosin structure organization|positive regulation of cell adhesion|negative regulation of cell motility FRMD6 3454.8699 3292.909939 3616.829862 1.098368899 0.13536268 0.568800888 1 27.64022512 29.85114413 122786 FERM domain containing 6 "GO:0005515,GO:0005737,GO:0005856,GO:0005886,GO:0031032" protein binding|cytoplasm|cytoskeleton|plasma membrane|actomyosin structure organization "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species FRMD8 860.6001887 981.1102913 740.0900861 0.754339336 -0.406714435 0.102968898 1 14.20896962 10.53902706 83786 FERM domain containing 8 "GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0032760,GO:0034451" protein binding|nucleoplasm|cytosol|plasma membrane|positive regulation of tumor necrosis factor production|centriolar satellite FRMPD1 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.014065859 0.019165335 22844 FERM and PDZ domain containing 1 "GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0008277,GO:0032991,GO:0090150" protein binding|cytosol|cytoskeleton|plasma membrane|cell cortex|regulation of G protein-coupled receptor signaling pathway|protein-containing complex|establishment of protein localization to membrane FRMPD3 12.049048 13.52538047 10.57271552 0.781694499 -0.355323209 0.80166462 1 0.087219031 0.067037759 84443 FERM and PDZ domain containing 3 "GO:0005856,GO:0005886,GO:0030667,GO:0043312,GO:0070821" cytoskeleton|plasma membrane|secretory granule membrane|neutrophil degranulation|tertiary granule membrane FRMPD4 24.17735392 29.13158871 19.22311912 0.65987198 -0.599741937 0.46413506 1 0.158772401 0.103016283 9758 FERM and PDZ domain containing 4 "GO:0005515,GO:0005546,GO:0005856,GO:0032991,GO:0043197,GO:0051835" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytoskeleton|protein-containing complex|dendritic spine|positive regulation of synapse structural plasticity" FRRS1 140.3030031 163.3449796 117.2610266 0.717873466 -0.478198521 0.251095896 1 1.166990809 0.823733096 391059 ferric chelate reductase 1 "GO:0000293,GO:0016021,GO:0046872,GO:0055114" ferric-chelate reductase activity|integral component of membrane|metal ion binding|oxidation-reduction process FRS2 490.7167334 480.6712138 500.7622531 1.041797883 0.059075411 0.836469291 1 3.514527914 3.600158707 10818 fibroblast growth factor receptor substrate 2 "GO:0000165,GO:0000186,GO:0000187,GO:0001702,GO:0001759,GO:0003281,GO:0005068,GO:0005104,GO:0005168,GO:0005515,GO:0005829,GO:0005886,GO:0005887,GO:0005912,GO:0007185,GO:0007186,GO:0007405,GO:0007411,GO:0008543,GO:0008595,GO:0012505,GO:0016020,GO:0019211,GO:0030900,GO:0042981,GO:0046619,GO:0048011,GO:0050678,GO:0051897,GO:0060527,GO:0070307,GO:0070372,GO:2000726" "MAPK cascade|activation of MAPKK activity|activation of MAPK activity|gastrulation with mouth forming second|organ induction|ventricular septum development|transmembrane receptor protein tyrosine kinase adaptor activity|fibroblast growth factor receptor binding|neurotrophin TRKA receptor binding|protein binding|cytosol|plasma membrane|integral component of plasma membrane|adherens junction|transmembrane receptor protein tyrosine phosphatase signaling pathway|G protein-coupled receptor signaling pathway|neuroblast proliferation|axon guidance|fibroblast growth factor receptor signaling pathway|anterior/posterior axis specification, embryo|endomembrane system|membrane|phosphatase activator activity|forebrain development|regulation of apoptotic process|optic placode formation involved in camera-type eye formation|neurotrophin TRK receptor signaling pathway|regulation of epithelial cell proliferation|positive regulation of protein kinase B signaling|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|lens fiber cell development|regulation of ERK1 and ERK2 cascade|negative regulation of cardiac muscle cell differentiation" "hsa04714,hsa04722,hsa05205" Thermogenesis|Neurotrophin signaling pathway|Proteoglycans in cancer FRS3 156.9647165 159.183324 154.7461089 0.972125126 -0.040786074 0.935497053 1 2.194039628 2.097190173 10817 fibroblast growth factor receptor substrate 3 "GO:0000165,GO:0005104,GO:0005515,GO:0005886,GO:0007165,GO:0008543,GO:0042802" MAPK cascade|fibroblast growth factor receptor binding|protein binding|plasma membrane|signal transduction|fibroblast growth factor receptor signaling pathway|identical protein binding FRY 111.3248998 121.7284243 100.9213754 0.829069923 -0.270434312 0.55778906 1 0.388193742 0.316454204 10129 FRY microtubule binding protein "GO:0000902,GO:0000922,GO:0005815,GO:0005938,GO:0030427,GO:0031175" cell morphogenesis|spindle pole|microtubule organizing center|cell cortex|site of polarized growth|neuron projection development FRYL 2461.861704 2532.36739 2391.356019 0.944316385 -0.082657792 0.727704247 1 10.04816307 9.3298654 285527 FRY like transcription coactivator "GO:0000902,GO:0005515,GO:0005938,GO:0030427,GO:0031175" cell morphogenesis|protein binding|cell cortex|site of polarized growth|neuron projection development FRZB 9.928591267 8.323311061 11.53387147 1.385731158 0.470647391 0.750315201 1 0.168448924 0.229518873 2487 frizzled related protein "GO:0001501,GO:0005515,GO:0005615,GO:0005737,GO:0008285,GO:0010721,GO:0014033,GO:0016020,GO:0017147,GO:0030178,GO:0030308,GO:0035567,GO:0043065,GO:0045600,GO:0060029,GO:0060070,GO:0061037,GO:0061053,GO:0070367,GO:0090090,GO:0090103" skeletal system development|protein binding|extracellular space|cytoplasm|negative regulation of cell population proliferation|negative regulation of cell development|neural crest cell differentiation|membrane|Wnt-protein binding|negative regulation of Wnt signaling pathway|negative regulation of cell growth|non-canonical Wnt signaling pathway|positive regulation of apoptotic process|positive regulation of fat cell differentiation|convergent extension involved in organogenesis|canonical Wnt signaling pathway|negative regulation of cartilage development|somite development|negative regulation of hepatocyte differentiation|negative regulation of canonical Wnt signaling pathway|cochlea morphogenesis FSCN1 6501.087431 6190.462602 6811.71226 1.100355934 0.137970271 0.570806852 1 118.6686823 128.3927463 6624 fascin actin-bundling protein 1 "GO:0001725,GO:0001726,GO:0002102,GO:0003723,GO:0003779,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005902,GO:0005911,GO:0005938,GO:0007043,GO:0007163,GO:0008144,GO:0010592,GO:0015629,GO:0016477,GO:0019221,GO:0030027,GO:0030035,GO:0030036,GO:0030046,GO:0030175,GO:0030426,GO:0030674,GO:0031253,GO:0032534,GO:0032956,GO:0035089,GO:0044393,GO:0045296,GO:0048870,GO:0051015,GO:0051017,GO:0051491,GO:0070062,GO:0071437,GO:0071803,GO:0090091" stress fiber|ruffle|podosome|RNA binding|actin binding|protein binding|cytoplasm|cytosol|cytoskeleton|microvillus|cell-cell junction|cell cortex|cell-cell junction assembly|establishment or maintenance of cell polarity|drug binding|positive regulation of lamellipodium assembly|actin cytoskeleton|cell migration|cytokine-mediated signaling pathway|lamellipodium|microspike assembly|actin cytoskeleton organization|parallel actin filament bundle assembly|filopodium|growth cone|protein-macromolecule adaptor activity|cell projection membrane|regulation of microvillus assembly|regulation of actin cytoskeleton organization|establishment of apical/basal cell polarity|microspike|cadherin binding|cell motility|actin filament binding|actin filament bundle assembly|positive regulation of filopodium assembly|extracellular exosome|invadopodium|positive regulation of podosome assembly|positive regulation of extracellular matrix disassembly hsa05206 MicroRNAs in cancer FSCN2 25.61908785 29.13158871 22.10658699 0.758852777 -0.398108076 0.63496867 1 0.266992847 0.199217888 25794 "fascin actin-bundling protein 2, retinal" "GO:0003779,GO:0005515,GO:0005737,GO:0007163,GO:0007601,GO:0009653,GO:0015629,GO:0016477,GO:0030036,GO:0030674,GO:0032420,GO:0042462,GO:0051015,GO:0051017" actin binding|protein binding|cytoplasm|establishment or maintenance of cell polarity|visual perception|anatomical structure morphogenesis|actin cytoskeleton|cell migration|actin cytoskeleton organization|protein-macromolecule adaptor activity|stereocilium|eye photoreceptor cell development|actin filament binding|actin filament bundle assembly FSD1 590.963802 563.9043244 618.0232797 1.095971875 0.132210776 0.619885843 1 17.27585384 18.61701758 79187 fibronectin type III and SPRY domain containing 1 "GO:0005634,GO:0005737,GO:0005813,GO:0005874,GO:0007049,GO:0008017,GO:0031122,GO:0032154,GO:0032465,GO:0042802,GO:0051301,GO:0051302,GO:0060236" nucleus|cytoplasm|centrosome|microtubule|cell cycle|microtubule binding|cytoplasmic microtubule organization|cleavage furrow|regulation of cytokinesis|identical protein binding|cell division|regulation of cell division|regulation of mitotic spindle organization FSD1L 261.1702654 258.0226429 264.3178879 1.024398033 0.034776388 0.9283869 1 1.443416586 1.453890189 83856 fibronectin type III and SPRY domain containing 1 like "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process FSIP1 11.60809898 14.56579436 8.650403604 0.593884782 -0.751745031 0.514922909 1 0.090378988 0.052776532 161835 fibrous sheath interacting protein 1 FSIP2 13.53041089 14.56579436 12.49502743 0.857833574 -0.221230314 0.898154764 1 0.037965796 0.032023348 401024 fibrous sheath interacting protein 2 "GO:0003674,GO:0007288,GO:0030317,GO:0061512,GO:0097224,GO:0097225,GO:0097228,GO:0097229" molecular_function|sperm axoneme assembly|flagellated sperm motility|protein localization to cilium|sperm connecting piece|sperm midpiece|sperm principal piece|sperm end piece FST 852.4756369 868.745592 836.2056817 0.962543798 -0.055075907 0.82969024 1 12.40325189 11.73889565 10468 follistatin "GO:0000122,GO:0001501,GO:0002244,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0007275,GO:0007276,GO:0007389,GO:0008585,GO:0030154,GO:0030509,GO:0030510,GO:0031069,GO:0032926,GO:0038102,GO:0042475,GO:0043395,GO:0043616,GO:0045596,GO:0048185,GO:0051798" negative regulation of transcription by RNA polymerase II|skeletal system development|hematopoietic progenitor cell differentiation|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|multicellular organism development|gamete generation|pattern specification process|female gonad development|cell differentiation|BMP signaling pathway|regulation of BMP signaling pathway|hair follicle morphogenesis|negative regulation of activin receptor signaling pathway|activin receptor antagonist activity|odontogenesis of dentin-containing tooth|heparan sulfate proteoglycan binding|keratinocyte proliferation|negative regulation of cell differentiation|activin binding|positive regulation of hair follicle development hsa04350 TGF-beta signaling pathway FSTL1 13470.58245 12767.95917 14173.20573 1.11006039 0.150638164 0.561128998 1 97.73415294 106.6753651 11167 follistatin like 1 "GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0007275,GO:0008201,GO:0030154,GO:0030509,GO:0030510,GO:0043066,GO:0043542,GO:0043687,GO:0044267,GO:0045446,GO:0061484,GO:0070062" calcium ion binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|multicellular organism development|heparin binding|cell differentiation|BMP signaling pathway|regulation of BMP signaling pathway|negative regulation of apoptotic process|endothelial cell migration|post-translational protein modification|cellular protein metabolic process|endothelial cell differentiation|hematopoietic stem cell homeostasis|extracellular exosome FSTL3 1563.163106 1383.750464 1742.575748 1.259313578 0.332637569 0.162645845 1 29.52747662 36.56212247 10272 follistatin like 3 "GO:0001503,GO:0001822,GO:0001968,GO:0002244,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005788,GO:0005794,GO:0006357,GO:0007275,GO:0007283,GO:0008584,GO:0022409,GO:0030141,GO:0030154,GO:0030324,GO:0030325,GO:0030510,GO:0030514,GO:0032926,GO:0043687,GO:0044267,GO:0044306,GO:0045671,GO:0045944,GO:0048185,GO:0071248,GO:0090101" ossification|kidney development|fibronectin binding|hematopoietic progenitor cell differentiation|protein binding|extracellular region|extracellular space|nucleus|nucleoplasm|endoplasmic reticulum lumen|Golgi apparatus|regulation of transcription by RNA polymerase II|multicellular organism development|spermatogenesis|male gonad development|positive regulation of cell-cell adhesion|secretory granule|cell differentiation|lung development|adrenal gland development|regulation of BMP signaling pathway|negative regulation of BMP signaling pathway|negative regulation of activin receptor signaling pathway|post-translational protein modification|cellular protein metabolic process|neuron projection terminus|negative regulation of osteoclast differentiation|positive regulation of transcription by RNA polymerase II|activin binding|cellular response to metal ion|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway FTCD 7.604959303 10.40413883 4.80577978 0.461910386 -1.11431511 0.425432296 1 0.116575639 0.052946433 10841 formimidoyltransferase cyclodeaminase "GO:0000139,GO:0005515,GO:0005542,GO:0005737,GO:0005783,GO:0005793,GO:0005794,GO:0005814,GO:0005829,GO:0005886,GO:0006548,GO:0006760,GO:0007010,GO:0008017,GO:0019556,GO:0019557,GO:0030407,GO:0030409,GO:0030412,GO:0030868,GO:0035999,GO:0070062" Golgi membrane|protein binding|folic acid binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|centriole|cytosol|plasma membrane|histidine catabolic process|folic acid-containing compound metabolic process|cytoskeleton organization|microtubule binding|histidine catabolic process to glutamate and formamide|histidine catabolic process to glutamate and formate|formimidoyltransferase activity|glutamate formimidoyltransferase activity|formimidoyltetrahydrofolate cyclodeaminase activity|smooth endoplasmic reticulum membrane|tetrahydrofolate interconversion|extracellular exosome "hsa00340,hsa00670" Histidine metabolism|One carbon pool by folate FTCDNL1 45.35235308 55.14193578 35.56277037 0.644931482 -0.632782199 0.313124594 1 0.147843445 0.093753357 348751 formiminotransferase cyclodeaminase N-terminal like "GO:0005542,GO:0016740" folic acid binding|transferase activity FTH1 98070.39929 112185.7481 83955.05044 0.74835754 -0.41820039 0.280233092 1 4976.847207 3662.137317 2495 ferritin heavy chain 1 "GO:0004322,GO:0005506,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0006826,GO:0006879,GO:0006880,GO:0006955,GO:0008043,GO:0008198,GO:0008199,GO:0008285,GO:0043312,GO:0044754,GO:0048147,GO:0055114,GO:0070062,GO:1904724,GO:1904813" ferroxidase activity|iron ion binding|protein binding|extracellular region|nucleus|cytoplasm|cytosol|iron ion transport|cellular iron ion homeostasis|intracellular sequestering of iron ion|immune response|intracellular ferritin complex|ferrous iron binding|ferric iron binding|negative regulation of cell population proliferation|neutrophil degranulation|autolysosome|negative regulation of fibroblast proliferation|oxidation-reduction process|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen "hsa04216,hsa04217,hsa04978" Ferroptosis|Necroptosis|Mineral absorption FTL 19531.05003 21269.181 17792.91906 0.83655873 -0.257461267 0.344398681 1 1303.211365 1071.96961 2512 ferritin light chain "GO:0005506,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0006826,GO:0006879,GO:0006880,GO:0008043,GO:0008198,GO:0008199,GO:0016020,GO:0035578,GO:0042802,GO:0043312,GO:0044754,GO:0055072,GO:0070062" iron ion binding|protein binding|extracellular region|cytoplasm|cytosol|iron ion transport|cellular iron ion homeostasis|intracellular sequestering of iron ion|intracellular ferritin complex|ferrous iron binding|ferric iron binding|membrane|azurophil granule lumen|identical protein binding|neutrophil degranulation|autolysosome|iron ion homeostasis|extracellular exosome "hsa04216,hsa04217,hsa04978" Ferroptosis|Necroptosis|Mineral absorption FTO 1356.668675 1299.476939 1413.860411 1.088022702 0.12170866 0.613658918 1 5.241530944 5.607474276 79068 FTO alpha-ketoglutarate dependent dioxygenase "GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006307,GO:0008198,GO:0010883,GO:0016607,GO:0016740,GO:0035515,GO:0035516,GO:0035552,GO:0035553,GO:0040014,GO:0042245,GO:0043231,GO:0043734,GO:0061157,GO:0070989,GO:0080111,GO:0090335,GO:1990931,GO:1990984" nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|DNA dealkylation involved in DNA repair|ferrous iron binding|regulation of lipid storage|nuclear speck|transferase activity|oxidative RNA demethylase activity|oxidative DNA demethylase activity|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|regulation of multicellular organism growth|RNA repair|intracellular membrane-bounded organelle|DNA-N1-methyladenine dioxygenase activity|mRNA destabilization|oxidative demethylation|DNA demethylation|regulation of brown fat cell differentiation|RNA N6-methyladenosine dioxygenase activity|tRNA demethylase activity FTSJ1 1880.233288 1759.339876 2001.1267 1.137430424 0.185778299 0.433364247 1 43.01087294 48.10323411 24140 FtsJ RNA 2'-O-methyltransferase 1 "GO:0001510,GO:0002128,GO:0002181,GO:0005515,GO:0005737,GO:0005829,GO:0006400,GO:0008173,GO:0008175,GO:0009020,GO:0030488,GO:0052666" RNA methylation|tRNA nucleoside ribose methylation|cytoplasmic translation|protein binding|cytoplasm|cytosol|tRNA modification|RNA methyltransferase activity|tRNA methyltransferase activity|tRNA (guanosine-2'-O-)-methyltransferase activity|tRNA methylation|tRNA (cytosine-2'-O-)-methyltransferase activity FTSJ3 1057.249702 1147.576513 966.9228917 0.842578147 -0.247117596 0.312765396 1 17.17443896 14.2286576 117246 FtsJ RNA 2'-O-methyltransferase 3 "GO:0000453,GO:0000463,GO:0000466,GO:0001510,GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0008173,GO:0008650,GO:0016435,GO:0030687,GO:0030688,GO:0031167,GO:0062105" "enzyme-directed rRNA 2'-O-methylation|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA methylation|RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|RNA methyltransferase activity|rRNA (uridine-2'-O-)-methyltransferase activity|rRNA (guanine) methyltransferase activity|preribosome, large subunit precursor|preribosome, small subunit precursor|rRNA methylation|RNA 2'-O-methyltransferase activity" FUBP1 3057.353269 3189.908964 2924.797574 0.916890609 -0.125178473 0.597602994 1 24.976464 22.51747334 8880 far upstream element binding protein 1 "GO:0003697,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0010468,GO:0010628" single-stranded DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of gene expression|positive regulation of gene expression FUBP3 1808.869359 1854.017539 1763.721179 0.951296923 -0.072032384 0.762986596 1 16.86475345 15.77492369 8939 far upstream element binding protein 3 "GO:0003697,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0006351,GO:0010468,GO:0010628,GO:0016020,GO:0045893,GO:0045944" "single-stranded DNA binding|RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|transcription, DNA-templated|regulation of gene expression|positive regulation of gene expression|membrane|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II" FUCA1 788.1379384 819.8461395 756.4297374 0.92264841 -0.116147104 0.648016873 1 13.11168165 11.89503741 2517 alpha-L-fucosidase 1 "GO:0004560,GO:0005515,GO:0005576,GO:0005737,GO:0005764,GO:0006004,GO:0006027,GO:0016139,GO:0019377,GO:0035578,GO:0043202,GO:0043312,GO:0070062" alpha-L-fucosidase activity|protein binding|extracellular region|cytoplasm|lysosome|fucose metabolic process|glycosaminoglycan catabolic process|glycoside catabolic process|glycolipid catabolic process|azurophil granule lumen|lysosomal lumen|neutrophil degranulation|extracellular exosome "hsa00511,hsa04142" Other glycan degradation|Lysosome FUCA2 1834.236196 1813.441397 1855.030995 1.022934073 0.032713168 0.892470222 1 40.57863078 40.81466275 2519 alpha-L-fucosidase 2 "GO:0004560,GO:0005515,GO:0005576,GO:0005615,GO:0005764,GO:0005788,GO:0006004,GO:0009617,GO:0016139,GO:0035578,GO:0043312,GO:0043687,GO:0044267,GO:0070062,GO:2000535" alpha-L-fucosidase activity|protein binding|extracellular region|extracellular space|lysosome|endoplasmic reticulum lumen|fucose metabolic process|response to bacterium|glycoside catabolic process|azurophil granule lumen|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|extracellular exosome|regulation of entry of bacterium into host cell "hsa00511,hsa04142" Other glycan degradation|Lysosome FUNDC1 389.454403 332.9324424 445.9763636 1.339540119 0.42173779 0.1478865 1 16.85767794 22.20366449 139341 FUN14 domain containing 1 "GO:0000422,GO:0001666,GO:0005515,GO:0005741,GO:0010243,GO:0016236,GO:0031307" autophagy of mitochondrion|response to hypoxia|protein binding|mitochondrial outer membrane|response to organonitrogen compound|macroautophagy|integral component of mitochondrial outer membrane hsa04137 Mitophagy - animal FUNDC2 845.2380134 741.8150983 948.6609286 1.27883745 0.354832898 0.155907464 1 6.287011021 7.905525539 65991 FUN14 domain containing 2 "GO:0000422,GO:0005515,GO:0005634,GO:0005739,GO:0031307" autophagy of mitochondrion|protein binding|nucleus|mitochondrion|integral component of mitochondrial outer membrane FUOM 11.52884105 12.48496659 10.57271552 0.846835707 -0.239845992 0.903809209 1 0.210122901 0.174961998 282969 fucose mutarotase "GO:0005829,GO:0006004,GO:0016857,GO:0036065,GO:0036373,GO:0042806" "cytosol|fucose metabolic process|racemase and epimerase activity, acting on carbohydrates and derivatives|fucosylation|L-fucose mutarotase activity|fucose binding" FURIN 1690.900042 1822.805122 1558.994961 0.855272427 -0.225544065 0.342555099 1 20.73753127 17.43944676 5045 "furin, paired basic amino acid cleaving enzyme" "GO:0000139,GO:0001825,GO:0002020,GO:0004175,GO:0004252,GO:0004867,GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0005796,GO:0005802,GO:0005886,GO:0006465,GO:0007179,GO:0008233,GO:0009966,GO:0009986,GO:0010008,GO:0010951,GO:0016020,GO:0016485,GO:0016486,GO:0019058,GO:0019082,GO:0022617,GO:0030140,GO:0030173,GO:0030198,GO:0030574,GO:0031638,GO:0032374,GO:0032455,GO:0032804,GO:0032902,GO:0032904,GO:0032911,GO:0032940,GO:0042176,GO:0042277,GO:0043043,GO:0044267,GO:0045121,GO:0046872,GO:0048406,GO:0051004,GO:0051044,GO:0052548,GO:0070062,GO:0070268,GO:0090472,GO:1901394" Golgi membrane|blastocyst formation|protease binding|endopeptidase activity|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum|Golgi lumen|trans-Golgi network|plasma membrane|signal peptide processing|transforming growth factor beta receptor signaling pathway|peptidase activity|regulation of signal transduction|cell surface|endosome membrane|negative regulation of endopeptidase activity|membrane|protein processing|peptide hormone processing|viral life cycle|viral protein processing|extracellular matrix disassembly|trans-Golgi network transport vesicle|integral component of Golgi membrane|extracellular matrix organization|collagen catabolic process|zymogen activation|regulation of cholesterol transport|nerve growth factor processing|negative regulation of low-density lipoprotein particle receptor catabolic process|nerve growth factor production|negative regulation of nerve growth factor production|negative regulation of transforming growth factor beta1 production|secretion by cell|regulation of protein catabolic process|peptide binding|peptide biosynthetic process|cellular protein metabolic process|membrane raft|metal ion binding|nerve growth factor binding|regulation of lipoprotein lipase activity|positive regulation of membrane protein ectodomain proteolysis|regulation of endopeptidase activity|extracellular exosome|cornification|dibasic protein processing|positive regulation of transforming growth factor beta1 activation FUS 2753.476959 2769.581756 2737.372163 0.988370232 -0.016876535 0.944733362 1 79.76658825 77.51965876 2521 FUS RNA binding protein "GO:0000398,GO:0003677,GO:0003682,GO:0003712,GO:0003713,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0008380,GO:0042802,GO:0043484,GO:0045893,GO:0046872,GO:0048255,GO:0051260,GO:1905168" "mRNA splicing, via spliceosome|DNA binding|chromatin binding|transcription coregulator activity|transcription coactivator activity|RNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|RNA splicing|identical protein binding|regulation of RNA splicing|positive regulation of transcription, DNA-templated|metal ion binding|mRNA stabilization|protein homooligomerization|positive regulation of double-strand break repair via homologous recombination" "hsa03013,hsa03015,hsa03040,hsa05014,hsa05022,hsa05202" RNA transport|mRNA surveillance pathway|Spliceosome|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Transcriptional misregulation in cancer FUT1 8.407599406 6.242483296 10.57271552 1.693671415 0.760154008 0.593857288 1 0.083769138 0.139503268 2523 fucosyltransferase 1 (H blood group) "GO:0001936,GO:0001954,GO:0005794,GO:0005887,GO:0005975,GO:0006486,GO:0008107,GO:0008417,GO:0010595,GO:0016020,GO:0021772,GO:0030155,GO:0031127,GO:0032580,GO:0036065,GO:0042355,GO:1903672,GO:1904906" "regulation of endothelial cell proliferation|positive regulation of cell-matrix adhesion|Golgi apparatus|integral component of plasma membrane|carbohydrate metabolic process|protein glycosylation|galactoside 2-alpha-L-fucosyltransferase activity|fucosyltransferase activity|positive regulation of endothelial cell migration|membrane|olfactory bulb development|regulation of cell adhesion|alpha-(1,2)-fucosyltransferase activity|Golgi cisterna membrane|fucosylation|L-fucose catabolic process|positive regulation of sprouting angiogenesis|positive regulation of endothelial cell-matrix adhesion via fibronectin" "hsa00601,hsa00603" Glycosphingolipid biosynthesis - lacto and neolacto series|Glycosphingolipid biosynthesis - globo and isoglobo series FUT10 189.8270725 201.8402932 177.8138519 0.880963107 -0.182846492 0.630285033 1 2.12253113 1.83858185 84750 fucosyltransferase 10 "GO:0005654,GO:0005783,GO:0005794,GO:0006457,GO:0006486,GO:0006605,GO:0007399,GO:0009566,GO:0016021,GO:0030097,GO:0032580,GO:0036065,GO:0042060,GO:0042355,GO:0046920" nucleoplasm|endoplasmic reticulum|Golgi apparatus|protein folding|protein glycosylation|protein targeting|nervous system development|fertilization|integral component of membrane|hemopoiesis|Golgi cisterna membrane|fucosylation|wound healing|L-fucose catabolic process|alpha-(1->3)-fucosyltransferase activity FUT11 483.8005578 450.4992112 517.1019043 1.147841975 0.198924038 0.472879447 1 10.24384956 11.56156094 170384 fucosyltransferase 11 "GO:0005515,GO:0006486,GO:0016021,GO:0032580,GO:0036065,GO:0046920" protein binding|protein glycosylation|integral component of membrane|Golgi cisterna membrane|fucosylation|alpha-(1->3)-fucosyltransferase activity FUT4 167.4531437 169.5874629 165.3188244 0.974829281 -0.036778509 0.941112115 1 1.514739951 1.45190374 2526 fucosyltransferase 4 "GO:0005794,GO:0005802,GO:0005975,GO:0006486,GO:0008417,GO:0009311,GO:0009986,GO:0016020,GO:0016021,GO:0017083,GO:0032580,GO:0036065,GO:0042355,GO:0046920,GO:0071944,GO:1903037,GO:1903238" Golgi apparatus|trans-Golgi network|carbohydrate metabolic process|protein glycosylation|fucosyltransferase activity|oligosaccharide metabolic process|cell surface|membrane|integral component of membrane|4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity|Golgi cisterna membrane|fucosylation|L-fucose catabolic process|alpha-(1->3)-fucosyltransferase activity|cell periphery|regulation of leukocyte cell-cell adhesion|positive regulation of leukocyte tethering or rolling "hsa00515,hsa00601" Mannose type O-glycan biosynthesis|Glycosphingolipid biosynthesis - lacto and neolacto series FUT8 1153.677913 1067.464644 1239.891183 1.16152904 0.216025225 0.374444507 1 6.160768478 7.03616701 2530 fucosyltransferase 8 "GO:0000139,GO:0001701,GO:0005515,GO:0005794,GO:0006487,GO:0006491,GO:0007179,GO:0007229,GO:0007585,GO:0008424,GO:0009312,GO:0010468,GO:0016020,GO:0016021,GO:0016477,GO:0017124,GO:0018279,GO:0032580,GO:0033578,GO:0036071,GO:0042355,GO:0043112,GO:0046368,GO:0046921,GO:0070062,GO:1900407" Golgi membrane|in utero embryonic development|protein binding|Golgi apparatus|protein N-linked glycosylation|N-glycan processing|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|respiratory gaseous exchange by respiratory system|glycoprotein 6-alpha-L-fucosyltransferase activity|oligosaccharide biosynthetic process|regulation of gene expression|membrane|integral component of membrane|cell migration|SH3 domain binding|protein N-linked glycosylation via asparagine|Golgi cisterna membrane|protein glycosylation in Golgi|N-glycan fucosylation|L-fucose catabolic process|receptor metabolic process|GDP-L-fucose metabolic process|alpha-(1->6)-fucosyltransferase activity|extracellular exosome|regulation of cellular response to oxidative stress "hsa00510,hsa00513,hsa00533,hsa05202" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Transcriptional misregulation in cancer FUT9 47.67598504 53.06110801 42.29086206 0.797021842 -0.327308833 0.610188123 1 0.175287763 0.137370349 10690 fucosyltransferase 9 "GO:0005515,GO:0005794,GO:0005802,GO:0005975,GO:0006486,GO:0008417,GO:0010976,GO:0016021,GO:0017083,GO:0030182,GO:0032588,GO:0033692,GO:0036065,GO:0042355,GO:0046920,GO:1903037,GO:1903236" protein binding|Golgi apparatus|trans-Golgi network|carbohydrate metabolic process|protein glycosylation|fucosyltransferase activity|positive regulation of neuron projection development|integral component of membrane|4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity|neuron differentiation|trans-Golgi network membrane|cellular polysaccharide biosynthetic process|fucosylation|L-fucose catabolic process|alpha-(1->3)-fucosyltransferase activity|regulation of leukocyte cell-cell adhesion|regulation of leukocyte tethering or rolling "hsa00515,hsa00601,hsa00603" Mannose type O-glycan biosynthesis|Glycosphingolipid biosynthesis - lacto and neolacto series|Glycosphingolipid biosynthesis - globo and isoglobo series FUZ 113.9309649 114.4455271 113.4164028 0.991007737 -0.013031774 0.999304716 1 2.530135642 2.465426321 80199 fuzzy planar cell polarity protein "GO:0001736,GO:0001843,GO:0001942,GO:0005515,GO:0005737,GO:0005856,GO:0008285,GO:0008589,GO:0010172,GO:0015031,GO:0016192,GO:0030336,GO:0042995,GO:0045724,GO:0048704,GO:0060271,GO:0070062,GO:0090090,GO:0090301,GO:1905515,GO:2000314" establishment of planar polarity|neural tube closure|hair follicle development|protein binding|cytoplasm|cytoskeleton|negative regulation of cell population proliferation|regulation of smoothened signaling pathway|embryonic body morphogenesis|protein transport|vesicle-mediated transport|negative regulation of cell migration|cell projection|positive regulation of cilium assembly|embryonic skeletal system morphogenesis|cilium assembly|extracellular exosome|negative regulation of canonical Wnt signaling pathway|negative regulation of neural crest formation|non-motile cilium assembly|negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation FXN 227.6291865 210.1636043 245.0947688 1.16620939 0.221826844 0.527547226 1 1.607343837 1.843132266 2395 frataxin "GO:0004322,GO:0005515,GO:0005739,GO:0005759,GO:0005829,GO:0006119,GO:0006783,GO:0006811,GO:0006879,GO:0007005,GO:0007628,GO:0008198,GO:0008199,GO:0008284,GO:0009060,GO:0009792,GO:0010039,GO:0010722,GO:0016226,GO:0016540,GO:0018283,GO:0019230,GO:0030307,GO:0034986,GO:0040015,GO:0043066,GO:0043085,GO:0044281,GO:0046621,GO:0051349,GO:0051537,GO:0070301,GO:0090201,GO:1904231,GO:1904234,GO:1990221" "ferroxidase activity|protein binding|mitochondrion|mitochondrial matrix|cytosol|oxidative phosphorylation|heme biosynthetic process|ion transport|cellular iron ion homeostasis|mitochondrion organization|adult walking behavior|ferrous iron binding|ferric iron binding|positive regulation of cell population proliferation|aerobic respiration|embryo development ending in birth or egg hatching|response to iron ion|regulation of ferrochelatase activity|iron-sulfur cluster assembly|protein autoprocessing|iron incorporation into metallo-sulfur cluster|proprioception|positive regulation of cell growth|iron chaperone activity|negative regulation of multicellular organism growth|negative regulation of apoptotic process|positive regulation of catalytic activity|small molecule metabolic process|negative regulation of organ growth|positive regulation of lyase activity|2 iron, 2 sulfur cluster binding|cellular response to hydrogen peroxide|negative regulation of release of cytochrome c from mitochondria|positive regulation of succinate dehydrogenase activity|positive regulation of aconitate hydratase activity|L-cysteine desulfurase complex" hsa00860 Porphyrin and chlorophyll metabolism FXR1 4358.243372 3971.25979 4745.226955 1.194892101 0.256880349 0.282110576 1 65.11177761 76.49964521 8087 FMR1 autosomal homolog 1 "GO:0000381,GO:0001934,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005844,GO:0006915,GO:0007517,GO:0014069,GO:0016020,GO:0017148,GO:0030154,GO:0030424,GO:0030426,GO:0033592,GO:0036464,GO:0042803,GO:0043025,GO:0043034,GO:0043197,GO:0043488,GO:0044326,GO:0045182,GO:0045727,GO:0046982,GO:0048471,GO:0051489,GO:0060538,GO:0098793,GO:0098978,GO:1902737,GO:2000637,GO:2001022" "regulation of alternative mRNA splicing, via spliceosome|positive regulation of protein phosphorylation|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleolus|cytoplasm|cytosol|polysome|apoptotic process|muscle organ development|postsynaptic density|membrane|negative regulation of translation|cell differentiation|axon|growth cone|RNA strand annealing activity|cytoplasmic ribonucleoprotein granule|protein homodimerization activity|neuronal cell body|costamere|dendritic spine|regulation of mRNA stability|dendritic spine neck|translation regulator activity|positive regulation of translation|protein heterodimerization activity|perinuclear region of cytoplasm|regulation of filopodium assembly|skeletal muscle organ development|presynapse|glutamatergic synapse|dendritic filopodium|positive regulation of gene silencing by miRNA|positive regulation of response to DNA damage stimulus" hsa03013 RNA transport FXR2 1538.65866 1371.265497 1706.051822 1.244144059 0.315153544 0.186198995 1 24.50014038 29.97163406 9513 FMR1 autosomal homolog 2 "GO:0000381,GO:0001934,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0014069,GO:0016020,GO:0017148,GO:0022625,GO:0030424,GO:0030426,GO:0036464,GO:0042802,GO:0042803,GO:0043025,GO:0043197,GO:0043488,GO:0044326,GO:0045182,GO:0045727,GO:0046982,GO:0051489,GO:0098793,GO:1902737,GO:2001022" "regulation of alternative mRNA splicing, via spliceosome|positive regulation of protein phosphorylation|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|cytosol|polysome|postsynaptic density|membrane|negative regulation of translation|cytosolic large ribosomal subunit|axon|growth cone|cytoplasmic ribonucleoprotein granule|identical protein binding|protein homodimerization activity|neuronal cell body|dendritic spine|regulation of mRNA stability|dendritic spine neck|translation regulator activity|positive regulation of translation|protein heterodimerization activity|regulation of filopodium assembly|presynapse|dendritic filopodium|positive regulation of response to DNA damage stimulus" hsa03013 RNA transport FXYD1 12.25222323 6.242483296 18.26196316 2.925432444 1.548649903 0.150303853 1 0.271515779 0.781009515 5348 FXYD domain containing ion transport regulator 1 "GO:0005254,GO:0005886,GO:0005887,GO:0005890,GO:0005901,GO:0006813,GO:0006814,GO:0006821,GO:0006936,GO:0008016,GO:0010734,GO:0014704,GO:0016324,GO:0017080,GO:0030315,GO:0034220,GO:0042383,GO:0044325,GO:0086036,GO:0099106,GO:1902476,GO:1903278,GO:1903779,GO:2000649" chloride channel activity|plasma membrane|integral component of plasma membrane|sodium:potassium-exchanging ATPase complex|caveola|potassium ion transport|sodium ion transport|chloride transport|muscle contraction|regulation of heart contraction|negative regulation of protein glutathionylation|intercalated disc|apical plasma membrane|sodium channel regulator activity|T-tubule|ion transmembrane transport|sarcolemma|ion channel binding|regulation of cardiac muscle cell membrane potential|ion channel regulator activity|chloride transmembrane transport|positive regulation of sodium ion export across plasma membrane|regulation of cardiac conduction|regulation of sodium ion transmembrane transporter activity hsa04024 cAMP signaling pathway FXYD5 2659.896273 2243.132331 3076.660215 1.371591044 0.455850389 0.054084257 1 136.3460704 183.8816724 53827 FXYD domain containing ion transport regulator 5 "GO:0003779,GO:0005515,GO:0006811,GO:0016021,GO:0017080,GO:0030033,GO:0045296,GO:0046588,GO:0099106,GO:2000649" actin binding|protein binding|ion transport|integral component of membrane|sodium channel regulator activity|microvillus assembly|cadherin binding|negative regulation of calcium-dependent cell-cell adhesion|ion channel regulator activity|regulation of sodium ion transmembrane transporter activity FXYD7 1.922311912 0 3.844623824 Inf Inf 0.288176591 1 0 0.284953516 53822 FXYD domain containing ion transport regulator 7 "GO:0005515,GO:0005886,GO:0016021,GO:0017080,GO:0034220,GO:0099106,GO:1903779,GO:2000649" protein binding|plasma membrane|integral component of membrane|sodium channel regulator activity|ion transmembrane transport|ion channel regulator activity|regulation of cardiac conduction|regulation of sodium ion transmembrane transporter activity FYCO1 1427.882306 1478.428127 1377.336485 0.931622214 -0.102183055 0.671080337 1 6.872908703 6.295809651 79443 FYVE and coiled-coil domain autophagy adaptor 1 "GO:0005515,GO:0005764,GO:0005770,GO:0005776,GO:0005794,GO:0016020,GO:0043231,GO:0046872,GO:0072383,GO:1901098" protein binding|lysosome|late endosome|autophagosome|Golgi apparatus|membrane|intracellular membrane-bounded organelle|metal ion binding|plus-end-directed vesicle transport along microtubule|positive regulation of autophagosome maturation hsa05132 Salmonella infection FYN 798.6320104 716.8451651 880.4188557 1.228185525 0.296528505 0.239059559 1 8.702618052 10.50957313 2534 "FYN proto-oncogene, Src family tyrosine kinase" "GO:0000165,GO:0000304,GO:0001764,GO:0002223,GO:0002250,GO:0003015,GO:0004713,GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005634,GO:0005739,GO:0005768,GO:0005829,GO:0005884,GO:0005886,GO:0006468,GO:0006816,GO:0007169,GO:0007411,GO:0007596,GO:0007612,GO:0007631,GO:0008360,GO:0010629,GO:0010730,GO:0010976,GO:0014068,GO:0014069,GO:0018108,GO:0019221,GO:0019899,GO:0030154,GO:0030168,GO:0030425,GO:0030900,GO:0031234,GO:0031295,GO:0031397,GO:0031802,GO:0035556,GO:0036120,GO:0038083,GO:0038096,GO:0042127,GO:0042177,GO:0042493,GO:0042531,GO:0042542,GO:0042608,GO:0042609,GO:0042610,GO:0042802,GO:0043014,GO:0043123,GO:0043524,GO:0043548,GO:0044297,GO:0044325,GO:0045087,GO:0045121,GO:0045471,GO:0046872,GO:0046875,GO:0048010,GO:0048013,GO:0048156,GO:0048471,GO:0048813,GO:0050321,GO:0050690,GO:0050730,GO:0050798,GO:0050804,GO:0050852,GO:0050900,GO:0050966,GO:0051428,GO:0051897,GO:0070851,GO:0071375,GO:0071560,GO:0090314,GO:0097038,GO:0097062,GO:0097386,GO:0097718,GO:0098685,GO:0098978,GO:0099092,GO:1900182,GO:1900449,GO:1901216,GO:1902951,GO:1903202,GO:1903997,GO:1904645,GO:1904646,GO:1905232,GO:1905430,GO:1905477,GO:1905664,GO:2001056,GO:2001240" "MAPK cascade|response to singlet oxygen|neuron migration|stimulatory C-type lectin receptor signaling pathway|adaptive immune response|heart process|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|protein binding|ATP binding|nucleus|mitochondrion|endosome|cytosol|actin filament|plasma membrane|protein phosphorylation|calcium ion transport|transmembrane receptor protein tyrosine kinase signaling pathway|axon guidance|blood coagulation|learning|feeding behavior|regulation of cell shape|negative regulation of gene expression|negative regulation of hydrogen peroxide biosynthetic process|positive regulation of neuron projection development|positive regulation of phosphatidylinositol 3-kinase signaling|postsynaptic density|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|enzyme binding|cell differentiation|platelet activation|dendrite|forebrain development|extrinsic component of cytoplasmic side of plasma membrane|T cell costimulation|negative regulation of protein ubiquitination|type 5 metabotropic glutamate receptor binding|intracellular signal transduction|cellular response to platelet-derived growth factor stimulus|peptidyl-tyrosine autophosphorylation|Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of cell population proliferation|negative regulation of protein catabolic process|response to drug|positive regulation of tyrosine phosphorylation of STAT protein|response to hydrogen peroxide|T cell receptor binding|CD4 receptor binding|CD8 receptor binding|identical protein binding|alpha-tubulin binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of neuron apoptotic process|phosphatidylinositol 3-kinase binding|cell body|ion channel binding|innate immune response|membrane raft|response to ethanol|metal ion binding|ephrin receptor binding|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|tau protein binding|perinuclear region of cytoplasm|dendrite morphogenesis|tau-protein kinase activity|regulation of defense response to virus by virus|regulation of peptidyl-tyrosine phosphorylation|activated T cell proliferation|modulation of chemical synaptic transmission|T cell receptor signaling pathway|leukocyte migration|detection of mechanical stimulus involved in sensory perception of pain|peptide hormone receptor binding|positive regulation of protein kinase B signaling|growth factor receptor binding|cellular response to peptide hormone stimulus|cellular response to transforming growth factor beta stimulus|positive regulation of protein targeting to membrane|perinuclear endoplasmic reticulum|dendritic spine maintenance|glial cell projection|disordered domain specific binding|Schaffer collateral - CA1 synapse|glutamatergic synapse|postsynaptic density, intracellular component|positive regulation of protein localization to nucleus|regulation of glutamate receptor signaling pathway|positive regulation of neuron death|negative regulation of dendritic spine maintenance|negative regulation of oxidative stress-induced cell death|positive regulation of non-membrane spanning protein tyrosine kinase activity|response to amyloid-beta|cellular response to amyloid-beta|cellular response to L-glutamate|cellular response to glycine|positive regulation of protein localization to membrane|regulation of calcium ion import across plasma membrane|positive regulation of cysteine-type endopeptidase activity|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa04071,hsa04072,hsa04360,hsa04380,hsa04510,hsa04520,hsa04611,hsa04650,hsa04660,hsa04664,hsa04725,hsa05020,hsa05130,hsa05416" Sphingolipid signaling pathway|Phospholipase D signaling pathway|Axon guidance|Osteoclast differentiation|Focal adhesion|Adherens junction|Platelet activation|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|Cholinergic synapse|Prion disease|Pathogenic Escherichia coli infection|Viral myocarditis FYTTD1 1299.048393 1376.467567 1221.62922 0.887510356 -0.172164141 0.475333613 1 10.47028851 9.136992256 84248 forty-two-three domain containing 1 "GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0006406,GO:0016607" RNA binding|mRNA binding|protein binding|nucleoplasm|mRNA export from nucleus|nuclear speck FZD1 390.5734604 438.0142446 343.1326763 0.78338246 -0.352211269 0.226599721 1 3.390776791 2.611825897 8321 frizzled class receptor 1 "GO:0004930,GO:0005102,GO:0005109,GO:0005515,GO:0005886,GO:0005925,GO:0007186,GO:0007267,GO:0009986,GO:0010976,GO:0016021,GO:0017147,GO:0030165,GO:0030182,GO:0035425,GO:0035567,GO:0042493,GO:0042813,GO:0044338,GO:0044339,GO:0045893,GO:0051091,GO:0060070,GO:0060071,GO:0099054,GO:1904886,GO:1904953,GO:1990909" "G protein-coupled receptor activity|signaling receptor binding|frizzled binding|protein binding|plasma membrane|focal adhesion|G protein-coupled receptor signaling pathway|cell-cell signaling|cell surface|positive regulation of neuron projection development|integral component of membrane|Wnt-protein binding|PDZ domain binding|neuron differentiation|autocrine signaling|non-canonical Wnt signaling pathway|response to drug|Wnt-activated receptor activity|canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt signaling pathway involved in osteoblast differentiation|positive regulation of transcription, DNA-templated|positive regulation of DNA-binding transcription factor activity|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|presynapse assembly|beta-catenin destruction complex disassembly|Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|Wnt signalosome" "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD2 531.3721328 563.9043244 498.8399412 0.884618045 -0.176873423 0.514551075 1 7.963624605 6.926881412 2535 frizzled class receptor 2 "GO:0003149,GO:0003150,GO:0003151,GO:0004930,GO:0005515,GO:0005737,GO:0005886,GO:0005925,GO:0007186,GO:0007223,GO:0007608,GO:0016021,GO:0016055,GO:0017147,GO:0030165,GO:0030182,GO:0030669,GO:0030855,GO:0035567,GO:0042813,GO:0045893,GO:0051091,GO:0060022,GO:0060070,GO:0060071,GO:0060119,GO:0090103,GO:0090179,GO:1904886" "membranous septum morphogenesis|muscular septum morphogenesis|outflow tract morphogenesis|G protein-coupled receptor activity|protein binding|cytoplasm|plasma membrane|focal adhesion|G protein-coupled receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|sensory perception of smell|integral component of membrane|Wnt signaling pathway|Wnt-protein binding|PDZ domain binding|neuron differentiation|clathrin-coated endocytic vesicle membrane|epithelial cell differentiation|non-canonical Wnt signaling pathway|Wnt-activated receptor activity|positive regulation of transcription, DNA-templated|positive regulation of DNA-binding transcription factor activity|hard palate development|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|inner ear receptor cell development|cochlea morphogenesis|planar cell polarity pathway involved in neural tube closure|beta-catenin destruction complex disassembly" "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD3 149.1962109 157.1024963 141.2899255 0.899348698 -0.153047504 0.718509067 1 1.9750934 1.746573743 7976 frizzled class receptor 3 "GO:0001736,GO:0001764,GO:0001843,GO:0001942,GO:0002052,GO:0004930,GO:0005515,GO:0005737,GO:0005886,GO:0007186,GO:0007223,GO:0009986,GO:0016021,GO:0016324,GO:0016328,GO:0017147,GO:0030165,GO:0030182,GO:0030424,GO:0030425,GO:0032433,GO:0033278,GO:0035567,GO:0036342,GO:0036514,GO:0036515,GO:0042472,GO:0042493,GO:0042813,GO:0043025,GO:0045976,GO:0048786,GO:0051602,GO:0060070,GO:0060071,GO:0061549,GO:0071679,GO:1900118,GO:1904693,GO:1904938" "establishment of planar polarity|neuron migration|neural tube closure|hair follicle development|positive regulation of neuroblast proliferation|G protein-coupled receptor activity|protein binding|cytoplasm|plasma membrane|G protein-coupled receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|cell surface|integral component of membrane|apical plasma membrane|lateral plasma membrane|Wnt-protein binding|PDZ domain binding|neuron differentiation|axon|dendrite|filopodium tip|cell proliferation in midbrain|non-canonical Wnt signaling pathway|post-anal tail morphogenesis|dopaminergic neuron axon guidance|serotonergic neuron axon guidance|inner ear morphogenesis|response to drug|Wnt-activated receptor activity|neuronal cell body|negative regulation of mitotic cell cycle, embryonic|presynaptic active zone|response to electrical stimulus|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|sympathetic ganglion development|commissural neuron axon guidance|negative regulation of execution phase of apoptosis|midbrain morphogenesis|planar cell polarity pathway involved in axon guidance" "hsa04150,hsa04310,hsa04360,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05206,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Axon guidance|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD4 403.8119917 381.8318949 425.7920885 1.115129705 0.157211526 0.590413232 1 2.758584873 3.024704231 8322 frizzled class receptor 4 "GO:0001540,GO:0001570,GO:0004896,GO:0004930,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0005911,GO:0007186,GO:0007223,GO:0007605,GO:0009986,GO:0010812,GO:0016055,GO:0017147,GO:0019221,GO:0019955,GO:0030165,GO:0030182,GO:0030425,GO:0030665,GO:0030669,GO:0030947,GO:0031625,GO:0031987,GO:0034446,GO:0035426,GO:0035567,GO:0038023,GO:0042701,GO:0042803,GO:0042813,GO:0043507,GO:0044877,GO:0045893,GO:0046982,GO:0051091,GO:0060070,GO:0060071,GO:0061024,GO:0061299,GO:0061301,GO:0061304,GO:0071300,GO:0090090,GO:0098978,GO:0110135,GO:0150012,GO:1990830" "amyloid-beta binding|vasculogenesis|cytokine receptor activity|G protein-coupled receptor activity|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|cell-cell junction|G protein-coupled receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|sensory perception of sound|cell surface|negative regulation of cell-substrate adhesion|Wnt signaling pathway|Wnt-protein binding|cytokine-mediated signaling pathway|cytokine binding|PDZ domain binding|neuron differentiation|dendrite|clathrin-coated vesicle membrane|clathrin-coated endocytic vesicle membrane|regulation of vascular endothelial growth factor receptor signaling pathway|ubiquitin protein ligase binding|locomotion involved in locomotory behavior|substrate adhesion-dependent cell spreading|extracellular matrix-cell signaling|non-canonical Wnt signaling pathway|signaling receptor activity|progesterone secretion|protein homodimerization activity|Wnt-activated receptor activity|positive regulation of JUN kinase activity|protein-containing complex binding|positive regulation of transcription, DNA-templated|protein heterodimerization activity|positive regulation of DNA-binding transcription factor activity|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|membrane organization|retina vasculature morphogenesis in camera-type eye|cerebellum vasculature morphogenesis|retinal blood vessel morphogenesis|cellular response to retinoic acid|negative regulation of canonical Wnt signaling pathway|glutamatergic synapse|Norrin signaling pathway|positive regulation of neuron projection arborization|cellular response to leukemia inhibitory factor" "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD5 159.6349483 191.4361544 127.8337421 0.667761753 -0.58259463 0.141343499 1 1.103661631 0.724650613 7855 frizzled class receptor 5 "GO:0000139,GO:0000578,GO:0001525,GO:0001540,GO:0002726,GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0005923,GO:0007186,GO:0007223,GO:0007416,GO:0008285,GO:0008289,GO:0008595,GO:0009986,GO:0016021,GO:0017147,GO:0019901,GO:0030182,GO:0030424,GO:0030425,GO:0030669,GO:0031077,GO:0031625,GO:0031901,GO:0032729,GO:0032731,GO:0032760,GO:0033077,GO:0035567,GO:0042813,GO:0043204,GO:0043507,GO:0044877,GO:0045202,GO:0045944,GO:0048469,GO:0048471,GO:0048596,GO:0060061,GO:0060070,GO:0060071,GO:0060561,GO:0060670,GO:0060715,GO:0060716,GO:0060718,GO:0071219,GO:1901382,GO:1903146,GO:1903955,GO:1904886,GO:2000810" "Golgi membrane|embryonic axis specification|angiogenesis|amyloid-beta binding|positive regulation of T cell cytokine production|G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|bicellular tight junction|G protein-coupled receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|synapse assembly|negative regulation of cell population proliferation|lipid binding|anterior/posterior axis specification, embryo|cell surface|integral component of membrane|Wnt-protein binding|protein kinase binding|neuron differentiation|axon|dendrite|clathrin-coated endocytic vesicle membrane|post-embryonic camera-type eye development|ubiquitin protein ligase binding|early endosome membrane|positive regulation of interferon-gamma production|positive regulation of interleukin-1 beta production|positive regulation of tumor necrosis factor production|T cell differentiation in thymus|non-canonical Wnt signaling pathway|Wnt-activated receptor activity|perikaryon|positive regulation of JUN kinase activity|protein-containing complex binding|synapse|positive regulation of transcription by RNA polymerase II|cell maturation|perinuclear region of cytoplasm|embryonic camera-type eye morphogenesis|Spemann organizer formation|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|apoptotic process involved in morphogenesis|branching involved in labyrinthine layer morphogenesis|syncytiotrophoblast cell differentiation involved in labyrinthine layer development|labyrinthine layer blood vessel development|chorionic trophoblast cell differentiation|cellular response to molecule of bacterial origin|regulation of chorionic trophoblast cell proliferation|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion|beta-catenin destruction complex disassembly|regulation of bicellular tight junction assembly" "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD6 2032.138131 2151.575909 1912.700352 0.888976468 -0.169782865 0.473475199 1 31.11806283 27.20031897 8323 frizzled class receptor 6 "GO:0001540,GO:0001843,GO:0001942,GO:0004930,GO:0005515,GO:0005789,GO:0005886,GO:0005887,GO:0007186,GO:0007223,GO:0009986,GO:0016021,GO:0016324,GO:0016327,GO:0017147,GO:0030168,GO:0030659,GO:0031625,GO:0033278,GO:0035567,GO:0035880,GO:0042472,GO:0042813,GO:0043433,GO:0048105,GO:0060070,GO:0060071,GO:0090090,GO:1904693" "amyloid-beta binding|neural tube closure|hair follicle development|G protein-coupled receptor activity|protein binding|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|cell surface|integral component of membrane|apical plasma membrane|apicolateral plasma membrane|Wnt-protein binding|platelet activation|cytoplasmic vesicle membrane|ubiquitin protein ligase binding|cell proliferation in midbrain|non-canonical Wnt signaling pathway|embryonic nail plate morphogenesis|inner ear morphogenesis|Wnt-activated receptor activity|negative regulation of DNA-binding transcription factor activity|establishment of body hair planar orientation|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|negative regulation of canonical Wnt signaling pathway|midbrain morphogenesis" "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD7 292.2688254 304.8412676 279.6963832 0.917514828 -0.124196621 0.70303428 1 3.546722951 3.199716755 8324 frizzled class receptor 7 "GO:0004930,GO:0005109,GO:0005515,GO:0005546,GO:0005886,GO:0006355,GO:0007186,GO:0010812,GO:0014834,GO:0016021,GO:0017147,GO:0019827,GO:0030165,GO:0030182,GO:0033077,GO:0034446,GO:0035567,GO:0038031,GO:0042327,GO:0042666,GO:0042813,GO:0043231,GO:0045893,GO:0046330,GO:0048103,GO:0055038,GO:0060054,GO:0060070,GO:0060071,GO:0060231,GO:0060828,GO:0071300,GO:2000726" "G protein-coupled receptor activity|frizzled binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|plasma membrane|regulation of transcription, DNA-templated|G protein-coupled receptor signaling pathway|negative regulation of cell-substrate adhesion|skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration|integral component of membrane|Wnt-protein binding|stem cell population maintenance|PDZ domain binding|neuron differentiation|T cell differentiation in thymus|substrate adhesion-dependent cell spreading|non-canonical Wnt signaling pathway|non-canonical Wnt signaling pathway via JNK cascade|positive regulation of phosphorylation|negative regulation of ectodermal cell fate specification|Wnt-activated receptor activity|intracellular membrane-bounded organelle|positive regulation of transcription, DNA-templated|positive regulation of JNK cascade|somatic stem cell division|recycling endosome membrane|positive regulation of epithelial cell proliferation involved in wound healing|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|mesenchymal to epithelial transition|regulation of canonical Wnt signaling pathway|cellular response to retinoic acid|negative regulation of cardiac muscle cell differentiation" "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD8 198.6806514 194.5573961 202.8039067 1.042386004 0.059889619 0.883188941 1 2.563745839 2.627693572 8325 frizzled class receptor 8 "GO:0004930,GO:0005515,GO:0005794,GO:0005886,GO:0007186,GO:0016021,GO:0017147,GO:0030165,GO:0030182,GO:0031625,GO:0035567,GO:0042813,GO:0060070" G protein-coupled receptor activity|protein binding|Golgi apparatus|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|Wnt-protein binding|PDZ domain binding|neuron differentiation|ubiquitin protein ligase binding|non-canonical Wnt signaling pathway|Wnt-activated receptor activity|canonical Wnt signaling pathway "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZR1 1215.522789 1240.173348 1190.872229 0.960246591 -0.058523158 0.811725636 1 11.8761479 11.21319953 51343 fizzy and cell division cycle 20 related 1 "GO:0005515,GO:0005654,GO:0005680,GO:0005829,GO:0006281,GO:0006511,GO:0007049,GO:0008284,GO:0010997,GO:0031145,GO:0031965,GO:0040020,GO:0045732,GO:0051301,GO:0070306,GO:0070979,GO:0072425,GO:0090344,GO:1901990,GO:1904668,GO:1905786,GO:1990757" protein binding|nucleoplasm|anaphase-promoting complex|cytosol|DNA repair|ubiquitin-dependent protein catabolic process|cell cycle|positive regulation of cell population proliferation|anaphase-promoting complex binding|anaphase-promoting complex-dependent catabolic process|nuclear membrane|regulation of meiotic nuclear division|positive regulation of protein catabolic process|cell division|lens fiber cell differentiation|protein K11-linked ubiquitination|signal transduction involved in G2 DNA damage checkpoint|negative regulation of cell aging|regulation of mitotic cell cycle phase transition|positive regulation of ubiquitin protein ligase activity|positive regulation of anaphase-promoting complex-dependent catabolic process|ubiquitin ligase activator activity "hsa04110,hsa04120,hsa04914" Cell cycle|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation G0S2 11577.27625 12343.4703 10811.08219 0.875854353 -0.191237113 0.453153716 1 751.9958034 647.6173693 50486 G0/G1 switch 2 "GO:0003674,GO:0005515,GO:0005739,GO:0005811,GO:0019216,GO:0097191,GO:0120162,GO:2001238" molecular_function|protein binding|mitochondrion|lipid droplet|regulation of lipid metabolic process|extrinsic apoptotic signaling pathway|positive regulation of cold-induced thermogenesis|positive regulation of extrinsic apoptotic signaling pathway G2E3 842.0664676 860.4222809 823.7106543 0.957333013 -0.062907235 0.805493786 1 8.610379851 8.105065425 55632 G2/M-phase specific E3 ubiquitin protein ligase "GO:0004842,GO:0005515,GO:0005634,GO:0005730,GO:0005794,GO:0005829,GO:0006915,GO:0007275,GO:0016567,GO:0043231,GO:0046872" ubiquitin-protein transferase activity|protein binding|nucleus|nucleolus|Golgi apparatus|cytosol|apoptotic process|multicellular organism development|protein ubiquitination|intracellular membrane-bounded organelle|metal ion binding G3BP1 5863.956117 6004.228517 5723.683718 0.953275463 -0.069034933 0.775783194 1 31.33222261 29.36843448 10146 G3BP stress granule assembly factor 1 "GO:0003677,GO:0003678,GO:0003723,GO:0003724,GO:0003729,GO:0004519,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005925,GO:0007265,GO:0010494,GO:0016032,GO:0032508,GO:0032606,GO:0033677,GO:0034063,GO:0043204,GO:0045087,GO:0051607,GO:0062029,GO:0090305,GO:1990904" DNA binding|DNA helicase activity|RNA binding|RNA helicase activity|mRNA binding|endonuclease activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|focal adhesion|Ras protein signal transduction|cytoplasmic stress granule|viral process|DNA duplex unwinding|type I interferon production|DNA/RNA helicase activity|stress granule assembly|perikaryon|innate immune response|defense response to virus|positive regulation of stress granule assembly|nucleic acid phosphodiester bond hydrolysis|ribonucleoprotein complex G3BP2 3708.647214 3710.115906 3707.178522 0.999208277 -0.001142667 0.997462092 1 38.71765095 38.0396228 9908 G3BP stress granule assembly factor 2 "GO:0003723,GO:0003729,GO:0005515,GO:0005737,GO:0005829,GO:0007253,GO:0007265,GO:0010494,GO:0016032,GO:0030159,GO:0034063,GO:0045087,GO:0051028,GO:0051260,GO:0062029,GO:1990904" RNA binding|mRNA binding|protein binding|cytoplasm|cytosol|cytoplasmic sequestering of NF-kappaB|Ras protein signal transduction|cytoplasmic stress granule|viral process|signaling receptor complex adaptor activity|stress granule assembly|innate immune response|mRNA transport|protein homooligomerization|positive regulation of stress granule assembly|ribonucleoprotein complex G6PC3 743.3108227 753.259651 733.3619944 0.973584598 -0.03862175 0.884370469 1 21.63621267 20.71219446 92579 glucose-6-phosphatase catalytic subunit 3 "GO:0004346,GO:0005783,GO:0005789,GO:0006094,GO:0015760,GO:0016020,GO:0016021,GO:0016311,GO:0051156" glucose-6-phosphatase activity|endoplasmic reticulum|endoplasmic reticulum membrane|gluconeogenesis|glucose-6-phosphate transport|membrane|integral component of membrane|dephosphorylation|glucose 6-phosphate metabolic process "hsa00010,hsa00052,hsa00500,hsa04068,hsa04151,hsa04152,hsa04910,hsa04920,hsa04922,hsa04931,hsa04973" Glycolysis / Gluconeogenesis|Galactose metabolism|Starch and sucrose metabolism|FoxO signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance|Carbohydrate digestion and absorption G6PD 5417.905526 5989.662722 4846.14833 0.809085345 -0.305636204 0.204667194 1 137.4278981 109.3302692 2539 glucose-6-phosphate dehydrogenase "GO:0004345,GO:0005515,GO:0005536,GO:0005634,GO:0005737,GO:0005829,GO:0006006,GO:0006098,GO:0006629,GO:0006695,GO:0006739,GO:0006740,GO:0006749,GO:0009051,GO:0009898,GO:0010041,GO:0010734,GO:0014070,GO:0016020,GO:0019322,GO:0021762,GO:0032094,GO:0034451,GO:0034599,GO:0042802,GO:0042803,GO:0043231,GO:0043249,GO:0043523,GO:0045471,GO:0046390,GO:0050661,GO:0051156,GO:0055114,GO:0061052,GO:0070062,GO:1904879,GO:2000378" "glucose-6-phosphate dehydrogenase activity|protein binding|glucose binding|nucleus|cytoplasm|cytosol|glucose metabolic process|pentose-phosphate shunt|lipid metabolic process|cholesterol biosynthetic process|NADP metabolic process|NADPH regeneration|glutathione metabolic process|pentose-phosphate shunt, oxidative branch|cytoplasmic side of plasma membrane|response to iron(III) ion|negative regulation of protein glutathionylation|response to organic cyclic compound|membrane|pentose biosynthetic process|substantia nigra development|response to food|centriolar satellite|cellular response to oxidative stress|identical protein binding|protein homodimerization activity|intracellular membrane-bounded organelle|erythrocyte maturation|regulation of neuron apoptotic process|response to ethanol|ribose phosphate biosynthetic process|NADP binding|glucose 6-phosphate metabolic process|oxidation-reduction process|negative regulation of cell growth involved in cardiac muscle cell development|extracellular exosome|positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|negative regulation of reactive oxygen species metabolic process" "hsa00030,hsa00480,hsa05230" Pentose phosphate pathway|Glutathione metabolism|Central carbon metabolism in cancer GAA 485.2121092 525.4090107 445.0152076 0.846988153 -0.239586304 0.38563563 1 7.582507637 6.314825745 2548 alpha glucosidase "GO:0000023,GO:0002026,GO:0002086,GO:0003007,GO:0004553,GO:0004558,GO:0005764,GO:0005765,GO:0005886,GO:0005980,GO:0005985,GO:0006006,GO:0007040,GO:0007626,GO:0009888,GO:0016020,GO:0030246,GO:0032450,GO:0035577,GO:0043181,GO:0043202,GO:0043231,GO:0043312,GO:0046716,GO:0050884,GO:0050885,GO:0060048,GO:0070062,GO:0070821,GO:0101003" "maltose metabolic process|regulation of the force of heart contraction|diaphragm contraction|heart morphogenesis|hydrolase activity, hydrolyzing O-glycosyl compounds|alpha-1,4-glucosidase activity|lysosome|lysosomal membrane|plasma membrane|glycogen catabolic process|sucrose metabolic process|glucose metabolic process|lysosome organization|locomotory behavior|tissue development|membrane|carbohydrate binding|maltose alpha-glucosidase activity|azurophil granule membrane|vacuolar sequestering|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|muscle cell cellular homeostasis|neuromuscular process controlling posture|neuromuscular process controlling balance|cardiac muscle contraction|extracellular exosome|tertiary granule membrane|ficolin-1-rich granule membrane" "hsa00052,hsa00500,hsa04142" Galactose metabolism|Starch and sucrose metabolism|Lysosome GAB1 443.437038 438.0142446 448.8598314 1.024760809 0.035287207 0.908478469 1 1.141462728 1.150152483 2549 GRB2 associated binding protein 1 "GO:0001525,GO:0005515,GO:0005829,GO:0005911,GO:0007173,GO:0007411,GO:0008286,GO:0014068,GO:0031532,GO:0035728,GO:0038084,GO:0038089,GO:0038128,GO:0045766,GO:0051897,GO:0090668" angiogenesis|protein binding|cytosol|cell-cell junction|epidermal growth factor receptor signaling pathway|axon guidance|insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase signaling|actin cytoskeleton reorganization|response to hepatocyte growth factor|vascular endothelial growth factor signaling pathway|positive regulation of cell migration by vascular endothelial growth factor signaling pathway|ERBB2 signaling pathway|positive regulation of angiogenesis|positive regulation of protein kinase B signaling|endothelial cell chemotaxis to vascular endothelial growth factor "hsa01521,hsa04012,hsa04014,hsa04072,hsa04722,hsa05100,hsa05205,hsa05211,hsa05225,hsa05226" EGFR tyrosine kinase inhibitor resistance|ErbB signaling pathway|Ras signaling pathway|Phospholipase D signaling pathway|Neurotrophin signaling pathway|Bacterial invasion of epithelial cells|Proteoglycans in cancer|Renal cell carcinoma|Hepatocellular carcinoma|Gastric cancer GAB2 730.483058 883.3113864 577.6547296 0.653964999 -0.612714673 0.016165216 0.754468717 6.519251173 4.192020494 9846 GRB2 associated binding protein 2 "GO:0005068,GO:0005515,GO:0005547,GO:0005737,GO:0005829,GO:0005886,GO:0007169,GO:0007411,GO:0008284,GO:0019221,GO:0030316,GO:0038095,GO:0043306,GO:0043325,GO:0048015" "transmembrane receptor protein tyrosine kinase adaptor activity|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|cytosol|plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|axon guidance|positive regulation of cell population proliferation|cytokine-mediated signaling pathway|osteoclast differentiation|Fc-epsilon receptor signaling pathway|positive regulation of mast cell degranulation|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-mediated signaling" "hsa04014,hsa04071,hsa04072,hsa04380,hsa04664,hsa04666,hsa05220" Ras signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Osteoclast differentiation|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Chronic myeloid leukemia GAB3 88.26721772 96.75849109 79.77594435 0.824485205 -0.27843449 0.58059248 1 1.491572165 1.209200493 139716 GRB2 associated binding protein 3 GO:0030225 macrophage differentiation GABARAP 3164.490017 2772.702997 3556.277037 1.282602948 0.359074628 0.129749944 1 112.1865527 141.4829854 11337 GABA type A receptor-associated protein "GO:0000045,GO:0000139,GO:0000226,GO:0000421,GO:0000422,GO:0005515,GO:0005764,GO:0005776,GO:0005790,GO:0005829,GO:0005874,GO:0005875,GO:0005886,GO:0005930,GO:0006605,GO:0006995,GO:0007268,GO:0008017,GO:0008625,GO:0015629,GO:0016236,GO:0031410,GO:0031625,GO:0044297,GO:0045202,GO:0048471,GO:0048487,GO:0050811,GO:0097225,GO:0097352" autophagosome assembly|Golgi membrane|microtubule cytoskeleton organization|autophagosome membrane|autophagy of mitochondrion|protein binding|lysosome|autophagosome|smooth endoplasmic reticulum|cytosol|microtubule|microtubule associated complex|plasma membrane|axoneme|protein targeting|cellular response to nitrogen starvation|chemical synaptic transmission|microtubule binding|extrinsic apoptotic signaling pathway via death domain receptors|actin cytoskeleton|macroautophagy|cytoplasmic vesicle|ubiquitin protein ligase binding|cell body|synapse|perinuclear region of cytoplasm|beta-tubulin binding|GABA receptor binding|sperm midpiece|autophagosome maturation "hsa04068,hsa04136,hsa04137,hsa04140,hsa04371,hsa04621,hsa04727,hsa05014,hsa05022,hsa05131,hsa05167" FoxO signaling pathway|Autophagy - other|Mitophagy - animal|Autophagy - animal|Apelin signaling pathway|NOD-like receptor signaling pathway|GABAergic synapse|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Shigellosis|Kaposi sarcoma-associated herpesvirus infection GABARAPL1 2100.579577 1954.937685 2246.221469 1.148999012 0.200377557 0.397180888 1 45.22385403 51.09264716 23710 GABA type A receptor associated protein like 1 "GO:0000045,GO:0000421,GO:0000422,GO:0005515,GO:0005739,GO:0005776,GO:0005783,GO:0005794,GO:0005829,GO:0005874,GO:0006995,GO:0016236,GO:0030659,GO:0030957,GO:0031625,GO:0032590,GO:0032839,GO:0044297,GO:0048487,GO:0050811,GO:0097352" autophagosome assembly|autophagosome membrane|autophagy of mitochondrion|protein binding|mitochondrion|autophagosome|endoplasmic reticulum|Golgi apparatus|cytosol|microtubule|cellular response to nitrogen starvation|macroautophagy|cytoplasmic vesicle membrane|Tat protein binding|ubiquitin protein ligase binding|dendrite membrane|dendrite cytoplasm|cell body|beta-tubulin binding|GABA receptor binding|autophagosome maturation "hsa04068,hsa04136,hsa04137,hsa04140,hsa04371,hsa04621,hsa04727,hsa05014,hsa05022,hsa05131,hsa05167" FoxO signaling pathway|Autophagy - other|Mitophagy - animal|Autophagy - animal|Apelin signaling pathway|NOD-like receptor signaling pathway|GABAergic synapse|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Shigellosis|Kaposi sarcoma-associated herpesvirus infection GABARAPL2 1386.604133 1151.738168 1621.470098 1.407846108 0.493489642 0.039623028 1 63.10692939 87.35814679 11345 GABA type A receptor associated protein like 2 "GO:0000045,GO:0000139,GO:0000149,GO:0000421,GO:0000422,GO:0005515,GO:0005737,GO:0005776,GO:0005789,GO:0005794,GO:0005829,GO:0006891,GO:0006914,GO:0006995,GO:0008017,GO:0015031,GO:0016236,GO:0031410,GO:0031625,GO:0032781,GO:0048487,GO:0050811,GO:0051117,GO:0070972,GO:0097352,GO:1901799" autophagosome assembly|Golgi membrane|SNARE binding|autophagosome membrane|autophagy of mitochondrion|protein binding|cytoplasm|autophagosome|endoplasmic reticulum membrane|Golgi apparatus|cytosol|intra-Golgi vesicle-mediated transport|autophagy|cellular response to nitrogen starvation|microtubule binding|protein transport|macroautophagy|cytoplasmic vesicle|ubiquitin protein ligase binding|positive regulation of ATPase activity|beta-tubulin binding|GABA receptor binding|ATPase binding|protein localization to endoplasmic reticulum|autophagosome maturation|negative regulation of proteasomal protein catabolic process "hsa04068,hsa04136,hsa04137,hsa04140,hsa04371,hsa04621,hsa04727,hsa05014,hsa05022,hsa05131,hsa05167" FoxO signaling pathway|Autophagy - other|Mitophagy - animal|Autophagy - animal|Apelin signaling pathway|NOD-like receptor signaling pathway|GABAergic synapse|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Shigellosis|Kaposi sarcoma-associated herpesvirus infection GABBR1 886.472756 878.109317 894.836195 1.019048742 0.027223059 0.917551904 1 7.926772725 7.942597271 2550 gamma-aminobutyric acid type B receptor subunit 1 "GO:0004888,GO:0004965,GO:0005515,GO:0005576,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007193,GO:0007214,GO:0030425,GO:0038039,GO:0042734,GO:0045211,GO:0060078,GO:0098685,GO:0098982,GO:0099579,GO:0150099" transmembrane signaling receptor activity|G protein-coupled GABA receptor activity|protein binding|extracellular region|cytoplasm|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|gamma-aminobutyric acid signaling pathway|dendrite|G protein-coupled receptor heterodimeric complex|presynaptic membrane|postsynaptic membrane|regulation of postsynaptic membrane potential|Schaffer collateral - CA1 synapse|GABA-ergic synapse|G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential|neuron-glial cell signaling "hsa04024,hsa04080,hsa04727,hsa04742,hsa04915,hsa04929,hsa05032" cAMP signaling pathway|Neuroactive ligand-receptor interaction|GABAergic synapse|Taste transduction|Estrogen signaling pathway|GnRH secretion|Morphine addiction GABBR2 10.36954028 7.282897178 13.45618338 1.847641543 0.88568489 0.46436189 1 0.063260878 0.114927541 9568 gamma-aminobutyric acid type B receptor subunit 2 "GO:0004888,GO:0004965,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007194,GO:0007214,GO:0007268,GO:0038039,GO:0043005,GO:0045211,GO:0046982,GO:0150099,GO:1902710" transmembrane signaling receptor activity|G protein-coupled GABA receptor activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|gamma-aminobutyric acid signaling pathway|chemical synaptic transmission|G protein-coupled receptor heterodimeric complex|neuron projection|postsynaptic membrane|protein heterodimerization activity|neuron-glial cell signaling|GABA receptor complex "hsa04024,hsa04080,hsa04727,hsa04742,hsa04915,hsa04929,hsa05032" cAMP signaling pathway|Neuroactive ligand-receptor interaction|GABAergic synapse|Taste transduction|Estrogen signaling pathway|GnRH secretion|Morphine addiction GABPA 854.4470242 945.7362193 763.1578291 0.806945757 -0.309456397 0.215305902 1 9.964897105 7.906573989 2551 GA binding protein transcription factor subunit alpha "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001825,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007005,GO:0010628,GO:0030154,GO:0033613,GO:0045653,GO:0045944,GO:1903351,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|blastocyst formation|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|mitochondrion organization|positive regulation of gene expression|cell differentiation|activating transcription factor binding|negative regulation of megakaryocyte differentiation|positive regulation of transcription by RNA polymerase II|cellular response to dopamine|sequence-specific double-stranded DNA binding" ETS GABPB1 491.9552921 487.954111 495.9564733 1.016399826 0.023468033 0.939793394 1 5.091146448 5.088049763 2553 GA binding protein transcription factor subunit beta 1 "GO:0000976,GO:0005515,GO:0005634,GO:0005654,GO:0007005,GO:0036464,GO:0045944" transcription regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|mitochondrion organization|cytoplasmic ribonucleoprotein granule|positive regulation of transcription by RNA polymerase II GABPB2 82.82234411 92.59683556 73.04785266 0.788880659 -0.342121027 0.502996122 1 1.256476717 0.974623621 126626 GA binding protein transcription factor subunit beta 2 "GO:0000976,GO:0005515,GO:0005634,GO:0045944" transcription regulatory region sequence-specific DNA binding|protein binding|nucleus|positive regulation of transcription by RNA polymerase II GABRA3 136.1514084 130.0517353 142.2510815 1.093803794 0.129353971 0.772637393 1 1.891693129 2.034516846 2556 gamma-aminobutyric acid type A receptor subunit alpha3 "GO:0004890,GO:0005237,GO:0005254,GO:0005515,GO:0005886,GO:0005887,GO:0007165,GO:0007214,GO:0007268,GO:0008503,GO:0022851,GO:0030594,GO:0032590,GO:0034220,GO:0034707,GO:0042391,GO:0043005,GO:0045202,GO:0050877,GO:0051932,GO:0060078,GO:0098794,GO:0098982,GO:0099060,GO:1902476,GO:1902711,GO:1904315" "GABA-A receptor activity|inhibitory extracellular ligand-gated ion channel activity|chloride channel activity|protein binding|plasma membrane|integral component of plasma membrane|signal transduction|gamma-aminobutyric acid signaling pathway|chemical synaptic transmission|benzodiazepine receptor activity|GABA-gated chloride ion channel activity|neurotransmitter receptor activity|dendrite membrane|ion transmembrane transport|chloride channel complex|regulation of membrane potential|neuron projection|synapse|nervous system process|synaptic transmission, GABAergic|regulation of postsynaptic membrane potential|postsynapse|GABA-ergic synapse|integral component of postsynaptic specialization membrane|chloride transmembrane transport|GABA-A receptor complex|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential" "hsa04080,hsa04723,hsa04727,hsa04742,hsa05032,hsa05033" Neuroactive ligand-receptor interaction|Retrograde endocannabinoid signaling|GABAergic synapse|Taste transduction|Morphine addiction|Nicotine addiction GABRB1 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.003277744 0.008932132 2560 gamma-aminobutyric acid type A receptor subunit beta1 "GO:0004890,GO:0005254,GO:0005635,GO:0005737,GO:0005886,GO:0005887,GO:0006811,GO:0007165,GO:0007214,GO:0007268,GO:0009636,GO:0015276,GO:0021954,GO:0022851,GO:0030425,GO:0030594,GO:0032570,GO:0034220,GO:0034707,GO:0042391,GO:0042698,GO:0043005,GO:0045202,GO:0045211,GO:0050811,GO:0050877,GO:0060078,GO:0071420,GO:0098982,GO:1902476,GO:1902711,GO:1904315" GABA-A receptor activity|chloride channel activity|nuclear envelope|cytoplasm|plasma membrane|integral component of plasma membrane|ion transport|signal transduction|gamma-aminobutyric acid signaling pathway|chemical synaptic transmission|response to toxic substance|ligand-gated ion channel activity|central nervous system neuron development|GABA-gated chloride ion channel activity|dendrite|neurotransmitter receptor activity|response to progesterone|ion transmembrane transport|chloride channel complex|regulation of membrane potential|ovulation cycle|neuron projection|synapse|postsynaptic membrane|GABA receptor binding|nervous system process|regulation of postsynaptic membrane potential|cellular response to histamine|GABA-ergic synapse|chloride transmembrane transport|GABA-A receptor complex|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential "hsa04080,hsa04723,hsa04726,hsa04727,hsa05032,hsa05033" Neuroactive ligand-receptor interaction|Retrograde endocannabinoid signaling|Serotonergic synapse|GABAergic synapse|Morphine addiction|Nicotine addiction GABRG1 40.82900646 49.93986637 31.71814655 0.635126781 -0.654883491 0.315832798 1 0.386092841 0.241114514 2565 gamma-aminobutyric acid type A receptor subunit gamma1 "GO:0004890,GO:0005237,GO:0005254,GO:0005515,GO:0005886,GO:0005887,GO:0007165,GO:0007214,GO:0007268,GO:0008503,GO:0022851,GO:0030594,GO:0032590,GO:0034220,GO:0034707,GO:0042391,GO:0043005,GO:0045202,GO:0045211,GO:0050811,GO:0050877,GO:0051932,GO:0060078,GO:0098794,GO:1902476,GO:1902711,GO:1904315" "GABA-A receptor activity|inhibitory extracellular ligand-gated ion channel activity|chloride channel activity|protein binding|plasma membrane|integral component of plasma membrane|signal transduction|gamma-aminobutyric acid signaling pathway|chemical synaptic transmission|benzodiazepine receptor activity|GABA-gated chloride ion channel activity|neurotransmitter receptor activity|dendrite membrane|ion transmembrane transport|chloride channel complex|regulation of membrane potential|neuron projection|synapse|postsynaptic membrane|GABA receptor binding|nervous system process|synaptic transmission, GABAergic|regulation of postsynaptic membrane potential|postsynapse|chloride transmembrane transport|GABA-A receptor complex|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential" "hsa04080,hsa04723,hsa04727,hsa05032,hsa05033" Neuroactive ligand-receptor interaction|Retrograde endocannabinoid signaling|GABAergic synapse|Morphine addiction|Nicotine addiction GABRR2 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.020900242 0.025313311 2570 gamma-aminobutyric acid type A receptor subunit rho2 "GO:0004890,GO:0005254,GO:0005886,GO:0005887,GO:0007165,GO:0007214,GO:0007268,GO:0007601,GO:0019904,GO:0030594,GO:0034220,GO:0034707,GO:0042391,GO:0043005,GO:0045202,GO:0045211,GO:0050877,GO:0060078,GO:0098982,GO:1902476,GO:1902711,GO:1904315" GABA-A receptor activity|chloride channel activity|plasma membrane|integral component of plasma membrane|signal transduction|gamma-aminobutyric acid signaling pathway|chemical synaptic transmission|visual perception|protein domain specific binding|neurotransmitter receptor activity|ion transmembrane transport|chloride channel complex|regulation of membrane potential|neuron projection|synapse|postsynaptic membrane|nervous system process|regulation of postsynaptic membrane potential|GABA-ergic synapse|chloride transmembrane transport|GABA-A receptor complex|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential "hsa04080,hsa04723,hsa04727,hsa05032,hsa05033" Neuroactive ligand-receptor interaction|Retrograde endocannabinoid signaling|GABAergic synapse|Morphine addiction|Nicotine addiction GAD1 62.65316028 55.14193578 70.16438479 1.272432384 0.347588994 0.5425533 1 0.655563325 0.820201466 2571 glutamate decarboxylase 1 "GO:0004351,GO:0005515,GO:0005886,GO:0005938,GO:0006538,GO:0006540,GO:0007268,GO:0007269,GO:0009449,GO:0012506,GO:0016595,GO:0018352,GO:0030170,GO:0035176,GO:0035641,GO:0042136,GO:0042493,GO:0043679,GO:0044877,GO:0047485,GO:0048786,GO:0060077,GO:0061202" glutamate decarboxylase activity|protein binding|plasma membrane|cell cortex|glutamate catabolic process|glutamate decarboxylation to succinate|chemical synaptic transmission|neurotransmitter secretion|gamma-aminobutyric acid biosynthetic process|vesicle membrane|glutamate binding|protein-pyridoxal-5-phosphate linkage|pyridoxal phosphate binding|social behavior|locomotory exploration behavior|neurotransmitter biosynthetic process|response to drug|axon terminus|protein-containing complex binding|protein N-terminus binding|presynaptic active zone|inhibitory synapse|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane "hsa00250,hsa00410,hsa00430,hsa00650,hsa04727,hsa04940" "Alanine, aspartate and glutamate metabolism|beta-Alanine metabolism|Taurine and hypotaurine metabolism|Butanoate metabolism|GABAergic synapse|Type I diabetes mellitus" GADD45A 3980.053656 3908.834957 4051.272355 1.03643986 0.051636405 0.829185591 1 154.295368 157.2418606 1647 growth arrest and DNA damage inducible alpha "GO:0000079,GO:0000122,GO:0000185,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006281,GO:0006915,GO:0006977,GO:0007050,GO:0007098,GO:0016525,GO:0016607,GO:0019900,GO:0033140,GO:0042770,GO:0042803,GO:0043065,GO:0043537,GO:0046330,GO:0046982,GO:0047485,GO:0051726,GO:0071260,GO:0071479,GO:0071850,GO:0071901,GO:1900745,GO:1990841,GO:2000379" "regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription by RNA polymerase II|activation of MAPKKK activity|protein binding|nucleus|nucleoplasm|cytoplasm|DNA repair|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|cell cycle arrest|centrosome cycle|negative regulation of angiogenesis|nuclear speck|kinase binding|negative regulation of peptidyl-serine phosphorylation of STAT protein|signal transduction in response to DNA damage|protein homodimerization activity|positive regulation of apoptotic process|negative regulation of blood vessel endothelial cell migration|positive regulation of JNK cascade|protein heterodimerization activity|protein N-terminus binding|regulation of cell cycle|cellular response to mechanical stimulus|cellular response to ionizing radiation|mitotic cell cycle arrest|negative regulation of protein serine/threonine kinase activity|positive regulation of p38MAPK cascade|promoter-specific chromatin binding|positive regulation of reactive oxygen species metabolic process" "hsa04010,hsa04064,hsa04068,hsa04110,hsa04115,hsa04210,hsa04218,hsa05169,hsa05200,hsa05202,hsa05210,hsa05212,hsa05213,hsa05214,hsa05216,hsa05217,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" MAPK signaling pathway|NF-kappa B signaling pathway|FoxO signaling pathway|Cell cycle|p53 signaling pathway|Apoptosis|Cellular senescence|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Thyroid cancer|Basal cell carcinoma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer GADD45B 473.2328727 438.0142446 508.4515007 1.160810423 0.215132379 0.4396104 1 17.05033931 19.46101574 4616 growth arrest and DNA damage inducible beta "GO:0000185,GO:0005515,GO:0005634,GO:0005737,GO:0006915,GO:0007275,GO:0030154,GO:0043065,GO:0046330,GO:0051726,GO:1900745" activation of MAPKKK activity|protein binding|nucleus|cytoplasm|apoptotic process|multicellular organism development|cell differentiation|positive regulation of apoptotic process|positive regulation of JNK cascade|regulation of cell cycle|positive regulation of p38MAPK cascade "hsa04010,hsa04064,hsa04068,hsa04110,hsa04115,hsa04210,hsa04218,hsa05169,hsa05200,hsa05202,hsa05210,hsa05212,hsa05213,hsa05214,hsa05216,hsa05217,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" MAPK signaling pathway|NF-kappa B signaling pathway|FoxO signaling pathway|Cell cycle|p53 signaling pathway|Apoptosis|Cellular senescence|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Thyroid cancer|Basal cell carcinoma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer GADD45GIP1 647.2461457 527.4898385 767.0024529 1.454061096 0.540087889 0.037436421 0.976326461 15.91360271 22.75214491 90480 GADD45G interacting protein 1 "GO:0005515,GO:0005654,GO:0005739,GO:0005759,GO:0005840,GO:0016032,GO:0070125,GO:0070126,GO:0071850" protein binding|nucleoplasm|mitochondrion|mitochondrial matrix|ribosome|viral process|mitochondrial translational elongation|mitochondrial translational termination|mitotic cell cycle arrest GAK 2002.08563 1993.432999 2010.73826 1.008681135 0.012470181 0.960276388 1 17.91610902 17.76923674 2580 cyclin G associated kinase "GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005794,GO:0005829,GO:0005925,GO:0006468,GO:0006898,GO:0007029,GO:0007030,GO:0007049,GO:0010977,GO:0016020,GO:0016191,GO:0030276,GO:0030332,GO:0031982,GO:0034067,GO:0043231,GO:0048471,GO:0051085,GO:0051087,GO:0061024,GO:0072318,GO:0072583,GO:0072659,GO:0090160,GO:0098793,GO:0106310,GO:0106311,GO:1905224" protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|Golgi apparatus|cytosol|focal adhesion|protein phosphorylation|receptor-mediated endocytosis|endoplasmic reticulum organization|Golgi organization|cell cycle|negative regulation of neuron projection development|membrane|synaptic vesicle uncoating|clathrin binding|cyclin binding|vesicle|protein localization to Golgi apparatus|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|chaperone cofactor-dependent protein refolding|chaperone binding|membrane organization|clathrin coat disassembly|clathrin-dependent endocytosis|protein localization to plasma membrane|Golgi to lysosome transport|presynapse|protein serine kinase activity|protein threonine kinase activity|clathrin-coated pit assembly GAL3ST1 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.043503507 0.013172309 9514 galactose-3-O-sulfotransferase 1 "GO:0000139,GO:0001733,GO:0005887,GO:0006487,GO:0006665,GO:0006681,GO:0006682,GO:0007283,GO:0008146,GO:0016020,GO:0042552,GO:0046486,GO:0050694" Golgi membrane|galactosylceramide sulfotransferase activity|integral component of plasma membrane|protein N-linked glycosylation|sphingolipid metabolic process|galactosylceramide metabolic process|galactosylceramide biosynthetic process|spermatogenesis|sulfotransferase activity|membrane|myelination|glycerolipid metabolic process|galactose 3-O-sulfotransferase activity "hsa00565,hsa00600" Ether lipid metabolism|Sphingolipid metabolism GAL3ST4 8.407599406 6.242483296 10.57271552 1.693671415 0.760154008 0.593857288 1 0.13852385 0.23068794 79690 galactose-3-O-sulfotransferase 4 "GO:0001733,GO:0006790,GO:0007267,GO:0008146,GO:0009100,GO:0009101,GO:0009247,GO:0009311,GO:0016020,GO:0016021,GO:0030166,GO:0032580,GO:0050656,GO:0050694,GO:0050698,GO:0070062" galactosylceramide sulfotransferase activity|sulfur compound metabolic process|cell-cell signaling|sulfotransferase activity|glycoprotein metabolic process|glycoprotein biosynthetic process|glycolipid biosynthetic process|oligosaccharide metabolic process|membrane|integral component of membrane|proteoglycan biosynthetic process|Golgi cisterna membrane|3'-phosphoadenosine 5'-phosphosulfate binding|galactose 3-O-sulfotransferase activity|proteoglycan sulfotransferase activity|extracellular exosome GALC 141.7749195 88.43518002 195.1146591 2.206301373 1.141629871 0.00625714 0.470145009 1.012577348 2.196666979 2581 galactosylceramidase "GO:0004336,GO:0005764,GO:0006683,GO:0006687,GO:0042552,GO:0043202" galactosylceramidase activity|lysosome|galactosylceramide catabolic process|glycosphingolipid metabolic process|myelination|lysosomal lumen "hsa00600,hsa04142" Sphingolipid metabolism|Lysosome GALE 1266.206159 1283.870731 1248.541587 0.97248232 -0.040256074 0.870520625 1 37.66785116 36.01834376 2582 UDP-galactose-4-epimerase "GO:0003974,GO:0003978,GO:0005829,GO:0019388,GO:0033499,GO:0042802,GO:0042803" UDP-N-acetylglucosamine 4-epimerase activity|UDP-glucose 4-epimerase activity|cytosol|galactose catabolic process|galactose catabolic process via UDP-galactose|identical protein binding|protein homodimerization activity "hsa00052,hsa00520" Galactose metabolism|Amino sugar and nucleotide sugar metabolism GALK1 480.0005933 439.0546585 520.9465281 1.186518622 0.246734743 0.3729607 1 14.06454992 16.40860181 2584 galactokinase 1 "GO:0004335,GO:0005515,GO:0005524,GO:0005534,GO:0005737,GO:0005829,GO:0006012,GO:0016020,GO:0019388,GO:0019402,GO:0046835,GO:0061623,GO:0070062" galactokinase activity|protein binding|ATP binding|galactose binding|cytoplasm|cytosol|galactose metabolic process|membrane|galactose catabolic process|galactitol metabolic process|carbohydrate phosphorylation|glycolytic process from galactose|extracellular exosome "hsa00052,hsa00520" Galactose metabolism|Amino sugar and nucleotide sugar metabolism GALK2 421.8261203 400.5593448 443.0928957 1.106185392 0.145593195 0.61441008 1 3.44569891 3.747800138 2585 galactokinase 2 "GO:0004335,GO:0005524,GO:0005829,GO:0005975,GO:0006012,GO:0033858,GO:0046835" galactokinase activity|ATP binding|cytosol|carbohydrate metabolic process|galactose metabolic process|N-acetylgalactosamine kinase activity|carbohydrate phosphorylation GALM 123.7557606 82.19269673 165.3188244 2.011356617 1.008168897 0.020887955 0.821508434 1.671037395 3.304809465 130589 galactose mutarotase "GO:0004034,GO:0005737,GO:0005975,GO:0006006,GO:0006012,GO:0030246,GO:0033499,GO:0042803,GO:0070062" aldose 1-epimerase activity|cytoplasm|carbohydrate metabolic process|glucose metabolic process|galactose metabolic process|carbohydrate binding|galactose catabolic process via UDP-galactose|protein homodimerization activity|extracellular exosome "hsa00010,hsa00052" Glycolysis / Gluconeogenesis|Galactose metabolism GALNS 508.3194811 526.4494246 490.1895376 0.931123703 -0.102955248 0.710504244 1 3.573144883 3.271366387 2588 galactosamine (N-acetyl)-6-sulfatase "GO:0003943,GO:0004065,GO:0005576,GO:0008484,GO:0035578,GO:0042340,GO:0043202,GO:0043312,GO:0043890,GO:0046872,GO:0070062" N-acetylgalactosamine-4-sulfatase activity|arylsulfatase activity|extracellular region|sulfuric ester hydrolase activity|azurophil granule lumen|keratan sulfate catabolic process|lysosomal lumen|neutrophil degranulation|N-acetylgalactosamine-6-sulfatase activity|metal ion binding|extracellular exosome "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome GALNT1 1497.080505 1490.913094 1503.247915 1.008273334 0.011886793 0.963358559 1 16.89326786 16.74800679 2589 polypeptide N-acetylgalactosaminyltransferase 1 "GO:0000139,GO:0004653,GO:0005576,GO:0005789,GO:0005794,GO:0006493,GO:0016020,GO:0016021,GO:0016266,GO:0018215,GO:0018242,GO:0018243,GO:0030145,GO:0030246,GO:0032580,GO:0048471" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|extracellular region|endoplasmic reticulum membrane|Golgi apparatus|protein O-linked glycosylation|membrane|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine|manganese ion binding|carbohydrate binding|Golgi cisterna membrane|perinuclear region of cytoplasm "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT10 1113.367885 1220.405484 1006.330286 0.824586827 -0.278256681 0.253416073 1 10.93165453 8.863259594 55568 polypeptide N-acetylgalactosaminyltransferase 10 "GO:0000139,GO:0004653,GO:0005794,GO:0006493,GO:0016021,GO:0016266,GO:0018215,GO:0030246,GO:0046872" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|Golgi apparatus|protein O-linked glycosylation|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|carbohydrate binding|metal ion binding "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT11 660.2808874 579.5105326 741.0512421 1.278753707 0.354738423 0.170220669 1 6.39392434 8.039435909 63917 polypeptide N-acetylgalactosaminyltransferase 11 "GO:0000139,GO:0004653,GO:0005112,GO:0005794,GO:0007220,GO:0007368,GO:0008593,GO:0016021,GO:0016266,GO:0018215,GO:0018243,GO:0030246,GO:0046872,GO:0060271,GO:0061314" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|Notch binding|Golgi apparatus|Notch receptor processing|determination of left/right symmetry|regulation of Notch signaling pathway|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|protein O-linked glycosylation via threonine|carbohydrate binding|metal ion binding|cilium assembly|Notch signaling involved in heart development "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT12 281.6961099 304.8412676 258.5509522 0.848149446 -0.237609602 0.464417143 1 4.041942404 3.370805408 79695 polypeptide N-acetylgalactosaminyltransferase 12 "GO:0000139,GO:0004653,GO:0005794,GO:0016021,GO:0016266,GO:0018215,GO:0030246,GO:0046872" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|Golgi apparatus|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|carbohydrate binding|metal ion binding "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT14 186.0170473 215.3656737 156.6684208 0.727453071 -0.459073913 0.21976231 1 3.558411821 2.545261268 79623 polypeptide N-acetylgalactosaminyltransferase 14 "GO:0000139,GO:0004653,GO:0005794,GO:0016021,GO:0016266,GO:0018215,GO:0030246,GO:0046872" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|Golgi apparatus|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|carbohydrate binding|metal ion binding "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT16 75.54447734 65.54607461 85.54288008 1.305080138 0.384138398 0.46618823 1 0.444030659 0.56979852 57452 polypeptide N-acetylgalactosaminyltransferase 16 "GO:0000139,GO:0004653,GO:0005794,GO:0016021,GO:0018215,GO:0018242,GO:0018243,GO:0030246,GO:0046872" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|Golgi apparatus|integral component of membrane|protein phosphopantetheinylation|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine|carbohydrate binding|metal ion binding "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT18 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.011029991 0.006679483 374378 polypeptide N-acetylgalactosaminyltransferase 18 "GO:0000139,GO:0004653,GO:0005575,GO:0005794,GO:0006493,GO:0016021,GO:0018215,GO:0030246,GO:0046872" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|cellular_component|Golgi apparatus|protein O-linked glycosylation|integral component of membrane|protein phosphopantetheinylation|carbohydrate binding|metal ion binding "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT2 2891.780236 2628.085468 3155.475004 1.200674423 0.263845001 0.264937176 1 22.29117787 26.31658037 2590 polypeptide N-acetylgalactosaminyltransferase 2 "GO:0000139,GO:0004653,GO:0005515,GO:0005576,GO:0005789,GO:0005794,GO:0005795,GO:0006493,GO:0016020,GO:0016266,GO:0018215,GO:0018242,GO:0018243,GO:0030145,GO:0030173,GO:0030246,GO:0032580,GO:0048471,GO:0051604" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|protein binding|extracellular region|endoplasmic reticulum membrane|Golgi apparatus|Golgi stack|protein O-linked glycosylation|membrane|O-glycan processing|protein phosphopantetheinylation|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine|manganese ion binding|integral component of Golgi membrane|carbohydrate binding|Golgi cisterna membrane|perinuclear region of cytoplasm|protein maturation "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT3 70.17886166 63.46524684 76.89247648 1.211568225 0.276875647 0.617130129 1 0.574948834 0.684933252 2591 polypeptide N-acetylgalactosaminyltransferase 3 "GO:0000139,GO:0004653,GO:0005509,GO:0005794,GO:0005975,GO:0008543,GO:0016020,GO:0016021,GO:0016266,GO:0018215,GO:0018242,GO:0018243,GO:0030145,GO:0030246,GO:0032580,GO:0048471,GO:0070062" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|calcium ion binding|Golgi apparatus|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|membrane|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine|manganese ion binding|carbohydrate binding|Golgi cisterna membrane|perinuclear region of cytoplasm|extracellular exosome "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT4 9.086322201 11.44455271 6.728091692 0.587885946 -0.766391806 0.566347083 1 0.113421494 0.065563121 8693 polypeptide N-acetylgalactosaminyltransferase 4 "GO:0000139,GO:0004653,GO:0005515,GO:0005794,GO:0016021,GO:0016266,GO:0018215,GO:0018242,GO:0018243,GO:0030145,GO:0030246,GO:0048471,GO:0070062" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|protein binding|Golgi apparatus|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine|manganese ion binding|carbohydrate binding|perinuclear region of cytoplasm|extracellular exosome "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT5 10.16636505 14.56579436 5.766935736 0.395923188 -1.336707531 0.252942837 1 0.073633577 0.028665401 11227 polypeptide N-acetylgalactosaminyltransferase 5 "GO:0000139,GO:0004653,GO:0005575,GO:0005794,GO:0006024,GO:0016021,GO:0016266,GO:0018215,GO:0030246,GO:0046872" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|cellular_component|Golgi apparatus|glycosaminoglycan biosynthetic process|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|carbohydrate binding|metal ion binding "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT6 1497.302573 1635.530624 1359.074522 0.830968557 -0.267134207 0.263109315 1 15.09081317 12.33015147 11226 polypeptide N-acetylgalactosaminyltransferase 6 "GO:0000139,GO:0004653,GO:0005515,GO:0005794,GO:0006493,GO:0016021,GO:0016266,GO:0018215,GO:0030246,GO:0046872,GO:0048471" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|protein binding|Golgi apparatus|protein O-linked glycosylation|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|carbohydrate binding|metal ion binding|perinuclear region of cytoplasm "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT7 1459.996128 1589.752413 1330.239843 0.836759128 -0.25711571 0.282089583 1 11.34101917 9.330904017 51809 polypeptide N-acetylgalactosaminyltransferase 7 "GO:0000139,GO:0004653,GO:0005794,GO:0005975,GO:0006493,GO:0016020,GO:0016021,GO:0016266,GO:0018215,GO:0030246,GO:0046872,GO:0070062" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|Golgi apparatus|carbohydrate metabolic process|protein O-linked glycosylation|membrane|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|carbohydrate binding|metal ion binding|extracellular exosome "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALNT9 2.561405743 4.161655531 0.961155956 0.230955193 -2.11431511 0.482263142 1 0.069623795 0.0158109 50614 polypeptide N-acetylgalactosaminyltransferase 9 "GO:0000139,GO:0004653,GO:0005794,GO:0006493,GO:0016021,GO:0016266,GO:0018215,GO:0030246,GO:0046872" Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|Golgi apparatus|protein O-linked glycosylation|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|carbohydrate binding|metal ion binding "hsa00512,hsa00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis GALT 630.4548702 654.4203322 606.4894082 0.926758199 -0.109735122 0.677695055 1 19.88907196 18.12391991 2592 galactose-1-phosphate uridylyltransferase "GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0006011,GO:0006012,GO:0006258,GO:0008108,GO:0008270,GO:0019388,GO:0033499" protein binding|cytoplasm|Golgi apparatus|cytosol|UDP-glucose metabolic process|galactose metabolic process|UDP-glucose catabolic process|UDP-glucose:hexose-1-phosphate uridylyltransferase activity|zinc ion binding|galactose catabolic process|galactose catabolic process via UDP-galactose "hsa00052,hsa00520,hsa04917" Galactose metabolism|Amino sugar and nucleotide sugar metabolism|Prolactin signaling pathway GAMT 59.65583594 39.53572754 79.77594435 2.017819054 1.012796808 0.072815899 1 0.954296298 1.893374991 2593 guanidinoacetate N-methyltransferase "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006600,GO:0006601,GO:0006936,GO:0007283,GO:0008168,GO:0008757,GO:0009887,GO:0030731,GO:0032259,GO:0040014" protein binding|nucleus|cytoplasm|cytosol|creatine metabolic process|creatine biosynthetic process|muscle contraction|spermatogenesis|methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|animal organ morphogenesis|guanidinoacetate N-methyltransferase activity|methylation|regulation of multicellular organism growth "hsa00260,hsa00330" "Glycine, serine and threonine metabolism|Arginine and proline metabolism" GAN 343.5271228 313.1645787 373.8896669 1.193907908 0.255691558 0.399730424 1 1.102514545 1.294274322 8139 gigaxonin "GO:0003674,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0007010,GO:0016567,GO:0031463,GO:0043687" molecular_function|protein binding|cytoplasm|cytosol|cytoskeleton|cytoskeleton organization|protein ubiquitination|Cul3-RING ubiquitin ligase complex|post-translational protein modification GANAB 10074.61839 8195.340154 11953.89662 1.458621168 0.544605236 0.030715051 0.895820653 104.28475 149.5665565 23193 glucosidase II alpha subunit "GO:0003723,GO:0004553,GO:0005515,GO:0005788,GO:0005794,GO:0005975,GO:0006457,GO:0006491,GO:0016020,GO:0017177,GO:0030246,GO:0033919,GO:0042470,GO:0043231,GO:0070062,GO:0090599" "RNA binding|hydrolase activity, hydrolyzing O-glycosyl compounds|protein binding|endoplasmic reticulum lumen|Golgi apparatus|carbohydrate metabolic process|protein folding|N-glycan processing|membrane|glucosidase II complex|carbohydrate binding|glucan 1,3-alpha-glucosidase activity|melanosome|intracellular membrane-bounded organelle|extracellular exosome|alpha-glucosidase activity" "hsa00510,hsa04141" N-Glycan biosynthesis|Protein processing in endoplasmic reticulum GANC 216.1003455 197.6786377 234.5220533 1.18638036 0.246566619 0.490063302 1 1.52629421 1.780464765 2595 "glucosidase alpha, neutral C" "GO:0000023,GO:0004553,GO:0004558,GO:0006491,GO:0030246,GO:0032450,GO:0090599" "maltose metabolic process|hydrolase activity, hydrolyzing O-glycosyl compounds|alpha-1,4-glucosidase activity|N-glycan processing|carbohydrate binding|maltose alpha-glucosidase activity|alpha-glucosidase activity" "hsa00052,hsa00500" Galactose metabolism|Starch and sucrose metabolism GAP43 4.003139677 4.161655531 3.844623824 0.923820772 -0.11431511 1 1 0.062370095 0.056654617 2596 growth associated protein 43 "GO:0001786,GO:0005515,GO:0005516,GO:0005737,GO:0005886,GO:0007205,GO:0009611,GO:0010001,GO:0014069,GO:0016198,GO:0030425,GO:0031103,GO:0031527,GO:0032584,GO:0035727,GO:0040008,GO:0042246,GO:0043204,GO:0045165,GO:0051489,GO:0098982,GO:0099150,GO:1901981" phosphatidylserine binding|protein binding|calmodulin binding|cytoplasm|plasma membrane|protein kinase C-activating G protein-coupled receptor signaling pathway|response to wounding|glial cell differentiation|postsynaptic density|axon choice point recognition|dendrite|axon regeneration|filopodium membrane|growth cone membrane|lysophosphatidic acid binding|regulation of growth|tissue regeneration|perikaryon|cell fate commitment|regulation of filopodium assembly|GABA-ergic synapse|regulation of postsynaptic specialization assembly|phosphatidylinositol phosphate binding GAPDH 94943.50314 87474.87801 102412.1283 1.170760458 0.227445926 0.552965402 1 3131.035189 3604.351799 2597 glyceraldehyde-3-phosphate dehydrogenase "GO:0000226,GO:0001819,GO:0004365,GO:0005515,GO:0005634,GO:0005737,GO:0005811,GO:0005829,GO:0005886,GO:0006094,GO:0006096,GO:0008017,GO:0010951,GO:0015630,GO:0016020,GO:0016241,GO:0017148,GO:0019828,GO:0031640,GO:0031965,GO:0031982,GO:0035605,GO:0035606,GO:0042802,GO:0043231,GO:0048471,GO:0050661,GO:0050821,GO:0050832,GO:0051287,GO:0051402,GO:0051873,GO:0061621,GO:0061844,GO:0070062,GO:0071346,GO:0097452,GO:0097718,GO:1990904" microtubule cytoskeleton organization|positive regulation of cytokine production|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|protein binding|nucleus|cytoplasm|lipid droplet|cytosol|plasma membrane|gluconeogenesis|glycolytic process|microtubule binding|negative regulation of endopeptidase activity|microtubule cytoskeleton|membrane|regulation of macroautophagy|negative regulation of translation|aspartic-type endopeptidase inhibitor activity|killing of cells of other organism|nuclear membrane|vesicle|peptidyl-cysteine S-nitrosylase activity|peptidyl-cysteine S-trans-nitrosylation|identical protein binding|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|NADP binding|protein stabilization|defense response to fungus|NAD binding|neuron apoptotic process|killing by host of symbiont cells|canonical glycolysis|antimicrobial humoral immune response mediated by antimicrobial peptide|extracellular exosome|cellular response to interferon-gamma|GAIT complex|disordered domain specific binding|ribonucleoprotein complex "hsa00010,hsa04066,hsa05010,hsa05130,hsa05132" Glycolysis / Gluconeogenesis|HIF-1 signaling pathway|Alzheimer disease|Pathogenic Escherichia coli infection|Salmonella infection GAPVD1 2175.265466 2262.900195 2087.630736 0.922546536 -0.116306408 0.623705668 1 16.43309625 14.906609 26130 GTPase activating protein and VPS9 domains 1 "GO:0005085,GO:0005096,GO:0005768,GO:0005829,GO:0005886,GO:0006897,GO:0007165,GO:0032794,GO:0043547,GO:0045296,GO:0051223,GO:0061024" guanyl-nucleotide exchange factor activity|GTPase activator activity|endosome|cytosol|plasma membrane|endocytosis|signal transduction|GTPase activating protein binding|positive regulation of GTPase activity|cadherin binding|regulation of protein transport|membrane organization GAR1 377.4644913 371.4277561 383.5012264 1.032505568 0.046149562 0.884205934 1 18.86052967 19.14773756 54433 GAR1 ribonucleoprotein "GO:0000454,GO:0000781,GO:0001650,GO:0003723,GO:0005515,GO:0005654,GO:0005697,GO:0007004,GO:0031118,GO:0031429,GO:0034513,GO:0070034,GO:0072589,GO:0090661" "snoRNA guided rRNA pseudouridine synthesis|chromosome, telomeric region|fibrillar center|RNA binding|protein binding|nucleoplasm|telomerase holoenzyme complex|telomere maintenance via telomerase|rRNA pseudouridine synthesis|box H/ACA snoRNP complex|box H/ACA snoRNA binding|telomerase RNA binding|box H/ACA scaRNP complex|box H/ACA telomerase RNP complex" hsa03008 Ribosome biogenesis in eukaryotes GAREM1 326.1816562 324.6091314 327.754181 1.009688728 0.0139106 0.975053126 1 2.020031802 2.005473341 64762 GRB2 associated regulator of MAPK1 subtype 1 "GO:0005515,GO:0005886,GO:0007173,GO:0008284,GO:0051781,GO:0070064,GO:0070374,GO:0071364" protein binding|plasma membrane|epidermal growth factor receptor signaling pathway|positive regulation of cell population proliferation|positive regulation of cell division|proline-rich region binding|positive regulation of ERK1 and ERK2 cascade|cellular response to epidermal growth factor stimulus GAREM2 57.68383423 63.46524684 51.90242162 0.817808552 -0.290164945 0.627508774 1 0.50349689 0.404873749 150946 GRB2 associated regulator of MAPK1 subtype 2 GARNL3 116.0067623 131.0921492 100.9213754 0.769850643 -0.377349516 0.400244683 1 1.196331578 0.905585003 84253 GTPase activating Rap/RanGAP domain like 3 "GO:0005096,GO:0005737,GO:0051056,GO:0090630" GTPase activator activity|cytoplasm|regulation of small GTPase mediated signal transduction|activation of GTPase activity GARRE1 399.9422158 444.2567279 355.6277037 0.800500435 -0.321025909 0.267619183 1 3.549276206 2.793653559 9710 granule associated Rac and RHOG effector 1 "GO:0000932,GO:0005515,GO:0016601,GO:0031267,GO:1905762" P-body|protein binding|Rac protein signal transduction|small GTPase binding|CCR4-NOT complex binding GARS1 7211.793294 7753.164253 6670.422335 0.860348384 -0.217007121 0.375589458 1 153.8186344 130.1231227 2617 glycyl-tRNA synthetase 1 "GO:0004081,GO:0004820,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006418,GO:0006426,GO:0015966,GO:0016740,GO:0030424,GO:0042802,GO:0046983,GO:0070062,GO:0070150" bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity|glycine-tRNA ligase activity|protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|tRNA aminoacylation for protein translation|glycyl-tRNA aminoacylation|diadenosine tetraphosphate biosynthetic process|transferase activity|axon|identical protein binding|protein dimerization activity|extracellular exosome|mitochondrial glycyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis GART 3181.777692 3302.273664 3061.28172 0.927022419 -0.109323866 0.645133945 1 39.82740703 36.30307796 2618 "phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase" "GO:0003360,GO:0004637,GO:0004641,GO:0004644,GO:0005524,GO:0005829,GO:0006164,GO:0006189,GO:0006544,GO:0009168,GO:0010033,GO:0010035,GO:0021549,GO:0021987,GO:0046084,GO:0046654,GO:0046872,GO:0070062" brainstem development|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|ATP binding|cytosol|purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process|glycine metabolic process|purine ribonucleoside monophosphate biosynthetic process|response to organic substance|response to inorganic substance|cerebellum development|cerebral cortex development|adenine biosynthetic process|tetrahydrofolate biosynthetic process|metal ion binding|extracellular exosome "hsa00230,hsa00670,hsa01523" Purine metabolism|One carbon pool by folate|Antifolate resistance GAS1 3.601819626 6.242483296 0.961155956 0.153970129 -2.699277611 0.237188726 1 0.105930003 0.01603713 2619 growth arrest specific 1 "GO:0005515,GO:0005886,GO:0007050,GO:0008589,GO:0010955,GO:0016021,GO:0035924,GO:0042981,GO:0045165,GO:0045930,GO:0046658,GO:0048589,GO:0060628" protein binding|plasma membrane|cell cycle arrest|regulation of smoothened signaling pathway|negative regulation of protein processing|integral component of membrane|cellular response to vascular endothelial growth factor stimulus|regulation of apoptotic process|cell fate commitment|negative regulation of mitotic cell cycle|anchored component of plasma membrane|developmental growth|regulation of ER to Golgi vesicle-mediated transport hsa04340 Hedgehog signaling pathway GAS2 1.922311912 0 3.844623824 Inf Inf 0.288176591 1 0 0.049351049 2620 growth arrest specific 2 "GO:0000226,GO:0001544,GO:0001547,GO:0005829,GO:0005874,GO:0005884,GO:0006915,GO:0007050,GO:0008017,GO:0008093,GO:0008360,GO:0008593,GO:0016020,GO:0030728,GO:0051015,GO:0051764,GO:0071711" microtubule cytoskeleton organization|initiation of primordial ovarian follicle growth|antral ovarian follicle growth|cytosol|microtubule|actin filament|apoptotic process|cell cycle arrest|microtubule binding|cytoskeletal anchor activity|regulation of cell shape|regulation of Notch signaling pathway|membrane|ovulation|actin filament binding|actin crosslink formation|basement membrane organization GAS2L1 613.9522871 561.8234966 666.0810775 1.18556999 0.245580835 0.349474707 1 8.958317128 10.44298872 10634 growth arrest specific 2 like 1 "GO:0000226,GO:0001578,GO:0005515,GO:0005737,GO:0005884,GO:0007050,GO:0008017,GO:0008093,GO:0009267,GO:0031110,GO:0035371,GO:0046966,GO:0051015,GO:0051764,GO:0097067,GO:1904825" microtubule cytoskeleton organization|microtubule bundle formation|protein binding|cytoplasm|actin filament|cell cycle arrest|microtubule binding|cytoskeletal anchor activity|cellular response to starvation|regulation of microtubule polymerization or depolymerization|microtubule plus-end|thyroid hormone receptor binding|actin filament binding|actin crosslink formation|cellular response to thyroid hormone stimulus|protein localization to microtubule plus-end GAS2L3 581.7082888 674.188196 489.2283816 0.725655514 -0.462643267 0.080127735 1 8.166179054 5.826672068 283431 growth arrest specific 2 like 3 "GO:0000226,GO:0003779,GO:0005515,GO:0005737,GO:0005874,GO:0005884,GO:0008017,GO:0008093,GO:0015629,GO:0015630,GO:0030036,GO:0051015,GO:0051764" microtubule cytoskeleton organization|actin binding|protein binding|cytoplasm|microtubule|actin filament|microtubule binding|cytoskeletal anchor activity|actin cytoskeleton|microtubule cytoskeleton|actin cytoskeleton organization|actin filament binding|actin crosslink formation GAS6 3796.387236 3326.203183 4266.571289 1.282715172 0.359200855 0.131083314 1 70.77884791 89.26986942 2621 growth arrest specific 6 "GO:0001764,GO:0001786,GO:0001934,GO:0001961,GO:0002576,GO:0003104,GO:0005102,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005788,GO:0005796,GO:0006468,GO:0006888,GO:0006909,GO:0006915,GO:0007165,GO:0007167,GO:0007596,GO:0009267,GO:0010628,GO:0010804,GO:0018105,GO:0019064,GO:0019079,GO:0030296,GO:0030674,GO:0030971,GO:0031093,GO:0031100,GO:0031589,GO:0032008,GO:0032148,GO:0032689,GO:0032692,GO:0032715,GO:0032720,GO:0032825,GO:0033138,GO:0035457,GO:0035690,GO:0035754,GO:0040008,GO:0043027,GO:0043066,GO:0043154,GO:0043277,GO:0043433,GO:0043491,GO:0043687,GO:0044267,GO:0045860,GO:0045892,GO:0046718,GO:0046813,GO:0046827,GO:0048018,GO:0048146,GO:0050766,GO:0050900,GO:0051897,GO:0061098,GO:0070062,GO:0070168,GO:0070374,GO:0070588,GO:0071307,GO:0071333,GO:0071363,GO:0072659,GO:0085029,GO:0097028,GO:0097241,GO:1900142,GO:2000270,GO:2000352,GO:2000510,GO:2000533,GO:2000669" "neuron migration|phosphatidylserine binding|positive regulation of protein phosphorylation|positive regulation of cytokine-mediated signaling pathway|platelet degranulation|positive regulation of glomerular filtration|signaling receptor binding|calcium ion binding|protein binding|extracellular region|extracellular space|cytoplasm|endoplasmic reticulum lumen|Golgi lumen|protein phosphorylation|endoplasmic reticulum to Golgi vesicle-mediated transport|phagocytosis|apoptotic process|signal transduction|enzyme linked receptor protein signaling pathway|blood coagulation|cellular response to starvation|positive regulation of gene expression|negative regulation of tumor necrosis factor-mediated signaling pathway|peptidyl-serine phosphorylation|fusion of virus membrane with host plasma membrane|viral genome replication|protein tyrosine kinase activator activity|protein-macromolecule adaptor activity|receptor tyrosine kinase binding|platelet alpha granule lumen|animal organ regeneration|cell-substrate adhesion|positive regulation of TOR signaling|activation of protein kinase B activity|negative regulation of interferon-gamma production|negative regulation of interleukin-1 production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|positive regulation of natural killer cell differentiation|positive regulation of peptidyl-serine phosphorylation|cellular response to interferon-alpha|cellular response to drug|B cell chemotaxis|regulation of growth|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|apoptotic cell clearance|negative regulation of DNA-binding transcription factor activity|protein kinase B signaling|post-translational protein modification|cellular protein metabolic process|positive regulation of protein kinase activity|negative regulation of transcription, DNA-templated|viral entry into host cell|receptor-mediated virion attachment to host cell|positive regulation of protein export from nucleus|receptor ligand activity|positive regulation of fibroblast proliferation|positive regulation of phagocytosis|leukocyte migration|positive regulation of protein kinase B signaling|positive regulation of protein tyrosine kinase activity|extracellular exosome|negative regulation of biomineral tissue development|positive regulation of ERK1 and ERK2 cascade|calcium ion transmembrane transport|cellular response to vitamin K|cellular response to glucose stimulus|cellular response to growth factor stimulus|protein localization to plasma membrane|extracellular matrix assembly|dendritic cell differentiation|hematopoietic stem cell migration to bone marrow|negative regulation of oligodendrocyte apoptotic process|negative regulation of fibroblast apoptotic process|negative regulation of endothelial cell apoptotic process|positive regulation of dendritic cell chemotaxis|negative regulation of renal albumin absorption|negative regulation of dendritic cell apoptotic process" hsa01521 EGFR tyrosine kinase inhibitor resistance GAS8 428.4598628 435.9334168 420.9863087 0.965712406 -0.050334484 0.867215773 1 4.264106533 4.048993089 2622 growth arrest specific 8 "GO:0003674,GO:0005515,GO:0005794,GO:0005829,GO:0005874,GO:0005886,GO:0005929,GO:0005930,GO:0008017,GO:0008285,GO:0030317,GO:0031514,GO:0034613,GO:0035082,GO:0036064,GO:0045880,GO:0060294,GO:1903566,GO:1904526" molecular_function|protein binding|Golgi apparatus|cytosol|microtubule|plasma membrane|cilium|axoneme|microtubule binding|negative regulation of cell population proliferation|flagellated sperm motility|motile cilium|cellular protein localization|axoneme assembly|ciliary basal body|positive regulation of smoothened signaling pathway|cilium movement involved in cell motility|positive regulation of protein localization to cilium|regulation of microtubule binding GASK1A 3.884252787 1.040413883 6.728091692 6.466745402 2.693039812 0.222326747 1 0.016383882 0.104177458 729085 golgi associated kinase 1A "GO:0005576,GO:0005783,GO:0005794,GO:0005901,GO:0043231" extracellular region|endoplasmic reticulum|Golgi apparatus|caveola|intracellular membrane-bounded organelle GASK1B 48.23582094 55.14193578 41.32970611 0.749514966 -0.41597081 0.506476842 1 0.551503704 0.406443256 51313 golgi associated kinase 1B "GO:0000139,GO:0005794,GO:0016021" Golgi membrane|Golgi apparatus|integral component of membrane GATA2 306.8000212 320.4474759 293.1525666 0.914822517 -0.128436218 0.688174964 1 4.526652416 4.071788134 2624 GATA binding protein 2 "GO:0000122,GO:0000978,GO:0000981,GO:0001228,GO:0001655,GO:0001709,GO:0001764,GO:0001892,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006909,GO:0007204,GO:0007596,GO:0008134,GO:0008270,GO:0010628,GO:0010629,GO:0010725,GO:0021514,GO:0021533,GO:0021902,GO:0021954,GO:0021983,GO:0033993,GO:0035019,GO:0035065,GO:0035854,GO:0042472,GO:0043306,GO:0043536,GO:0045165,GO:0045599,GO:0045648,GO:0045650,GO:0045654,GO:0045666,GO:0045746,GO:0045766,GO:0045944,GO:0048469,GO:0048873,GO:0050766,GO:0060100,GO:0060216,GO:0060872,GO:0061042,GO:0070345,GO:0070742,GO:0090050,GO:0090102,GO:0097154,GO:1902036,GO:1902895,GO:1903589,GO:1990837,GO:2000178,GO:2000352,GO:2000977" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|urogenital system development|cell fate determination|neuron migration|embryonic placenta development|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|phagocytosis|positive regulation of cytosolic calcium ion concentration|blood coagulation|transcription factor binding|zinc ion binding|positive regulation of gene expression|negative regulation of gene expression|regulation of primitive erythrocyte differentiation|ventral spinal cord interneuron differentiation|cell differentiation in hindbrain|commitment of neuronal cell to specific neuron type in forebrain|central nervous system neuron development|pituitary gland development|response to lipid|somatic stem cell population maintenance|regulation of histone acetylation|eosinophil fate commitment|inner ear morphogenesis|positive regulation of mast cell degranulation|positive regulation of blood vessel endothelial cell migration|cell fate commitment|negative regulation of fat cell differentiation|positive regulation of erythrocyte differentiation|negative regulation of macrophage differentiation|positive regulation of megakaryocyte differentiation|positive regulation of neuron differentiation|negative regulation of Notch signaling pathway|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|cell maturation|homeostasis of number of cells within a tissue|positive regulation of phagocytosis|positive regulation of phagocytosis, engulfment|definitive hemopoiesis|semicircular canal development|vascular wound healing|negative regulation of fat cell proliferation|C2H2 zinc finger domain binding|positive regulation of cell migration involved in sprouting angiogenesis|cochlea development|GABAergic neuron differentiation|regulation of hematopoietic stem cell differentiation|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|sequence-specific double-stranded DNA binding|negative regulation of neural precursor cell proliferation|negative regulation of endothelial cell apoptotic process|regulation of forebrain neuron differentiation" zf-GATA GATA3 16.05721809 5.202069413 26.91236677 5.173396322 2.371111717 0.017345421 0.770503287 0.082897845 0.421686959 2625 GATA binding protein 3 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0000987,GO:0001227,GO:0001228,GO:0001701,GO:0001709,GO:0001764,GO:0001806,GO:0001817,GO:0001822,GO:0001823,GO:0002088,GO:0002520,GO:0002572,GO:0003180,GO:0003215,GO:0003281,GO:0003677,GO:0003700,GO:0005134,GO:0005515,GO:0005634,GO:0005654,GO:0006338,GO:0006952,GO:0006959,GO:0007165,GO:0007411,GO:0007596,GO:0008134,GO:0008270,GO:0008285,GO:0008584,GO:0009615,GO:0009653,GO:0009791,GO:0009967,GO:0010332,GO:0010595,GO:0010719,GO:0010975,GO:0014065,GO:0016579,GO:0019221,GO:0030217,GO:0030218,GO:0030856,GO:0031929,GO:0032689,GO:0032703,GO:0032736,GO:0032753,GO:0032754,GO:0033600,GO:0035162,GO:0035457,GO:0035799,GO:0035898,GO:0042421,GO:0042472,GO:0042493,GO:0042802,GO:0043370,GO:0043523,GO:0043583,GO:0043627,GO:0045061,GO:0045064,GO:0045087,GO:0045165,GO:0045471,GO:0045582,GO:0045599,GO:0045786,GO:0045892,GO:0045893,GO:0045944,GO:0048469,GO:0048485,GO:0048538,GO:0048568,GO:0048589,GO:0048646,GO:0050728,GO:0050852,GO:0051569,GO:0051897,GO:0060017,GO:0060037,GO:0060065,GO:0060231,GO:0060374,GO:0060676,GO:0061085,GO:0061290,GO:0070888,GO:0071353,GO:0071356,GO:0071442,GO:0071599,GO:0071773,GO:0071837,GO:0072107,GO:0072178,GO:0072179,GO:0072182,GO:0072197,GO:0072676,GO:0090102,GO:1901536,GO:1902036,GO:1902895,GO:1990837,GO:2000114,GO:2000146,GO:2000352,GO:2000553,GO:2000607,GO:2000611,GO:2000617,GO:2000679,GO:2000683,GO:2000703,GO:2000734" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|in utero embryonic development|cell fate determination|neuron migration|type IV hypersensitivity|regulation of cytokine production|kidney development|mesonephros development|lens development in camera-type eye|immune system development|pro-T cell differentiation|aortic valve morphogenesis|cardiac right ventricle morphogenesis|ventricular septum development|DNA binding|DNA-binding transcription factor activity|interleukin-2 receptor binding|protein binding|nucleus|nucleoplasm|chromatin remodeling|defense response|humoral immune response|signal transduction|axon guidance|blood coagulation|transcription factor binding|zinc ion binding|negative regulation of cell population proliferation|male gonad development|response to virus|anatomical structure morphogenesis|post-embryonic development|positive regulation of signal transduction|response to gamma radiation|positive regulation of endothelial cell migration|negative regulation of epithelial to mesenchymal transition|regulation of neuron projection development|phosphatidylinositol 3-kinase signaling|protein deubiquitination|cytokine-mediated signaling pathway|T cell differentiation|erythrocyte differentiation|regulation of epithelial cell differentiation|TOR signaling|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|negative regulation of mammary gland epithelial cell proliferation|embryonic hemopoiesis|cellular response to interferon-alpha|ureter maturation|parathyroid hormone secretion|norepinephrine biosynthetic process|inner ear morphogenesis|response to drug|identical protein binding|regulation of CD4-positive, alpha-beta T cell differentiation|regulation of neuron apoptotic process|ear development|response to estrogen|thymic T cell selection|T-helper 2 cell differentiation|innate immune response|cell fate commitment|response to ethanol|positive regulation of T cell differentiation|negative regulation of fat cell differentiation|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cell maturation|sympathetic nervous system development|thymus development|embryonic organ development|developmental growth|anatomical structure formation involved in morphogenesis|negative regulation of inflammatory response|T cell receptor signaling pathway|regulation of histone H3-K4 methylation|positive regulation of protein kinase B signaling|parathyroid gland development|pharyngeal system development|uterus development|mesenchymal to epithelial transition|mast cell differentiation|ureteric bud formation|regulation of histone H3-K27 methylation|canonical Wnt signaling pathway involved in metanephric kidney development|E-box binding|cellular response to interleukin-4|cellular response to tumor necrosis factor|positive regulation of histone H3-K14 acetylation|otic vesicle development|cellular response to BMP stimulus|HMG box domain binding|positive regulation of ureteric bud formation|nephric duct morphogenesis|nephric duct formation|regulation of nephron tubule epithelial cell differentiation|ureter morphogenesis|lymphocyte migration|cochlea development|negative regulation of DNA demethylation|regulation of hematopoietic stem cell differentiation|positive regulation of pri-miRNA transcription by RNA polymerase II|sequence-specific double-stranded DNA binding|regulation of establishment of cell polarity|negative regulation of cell motility|negative regulation of endothelial cell apoptotic process|positive regulation of T-helper 2 cell cytokine production|negative regulation of cell proliferation involved in mesonephros development|positive regulation of thyroid hormone generation|positive regulation of histone H3-K9 acetylation|positive regulation of transcription regulatory region DNA binding|regulation of cellular response to X-ray|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation" "hsa04658,hsa04659,hsa04928,hsa05321" "Th1 and Th2 cell differentiation|Th17 cell differentiation|Parathyroid hormone synthesis, secretion and action|Inflammatory bowel disease" zf-GATA GATA4 6.926236509 5.202069413 8.650403604 1.662877389 0.733681797 0.660649523 1 0.061983676 0.101346495 2626 GATA binding protein 4 "GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001085,GO:0001216,GO:0001228,GO:0001947,GO:0003180,GO:0003190,GO:0003197,GO:0003208,GO:0003215,GO:0003281,GO:0003289,GO:0003290,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0007267,GO:0007492,GO:0007596,GO:0008134,GO:0008270,GO:0008584,GO:0009612,GO:0010507,GO:0010575,GO:0010667,GO:0016604,GO:0019901,GO:0030513,GO:0033189,GO:0033613,GO:0035054,GO:0042060,GO:0042493,GO:0043565,GO:0045165,GO:0045766,GO:0045893,GO:0045944,GO:0048617,GO:0051525,GO:0051891,GO:0051896,GO:0060290,GO:0060413,GO:0060575,GO:0061026,GO:0061049,GO:0070374,GO:0070410,GO:0071333,GO:0086004,GO:0090575,GO:1903202,GO:1990837,GO:2001234" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|DNA-binding transcription activator activity|DNA-binding transcription activator activity, RNA polymerase II-specific|heart looping|aortic valve morphogenesis|atrioventricular valve formation|endocardial cushion development|cardiac ventricle morphogenesis|cardiac right ventricle morphogenesis|ventricular septum development|atrial septum primum morphogenesis|atrial septum secundum morphogenesis|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|cell-cell signaling|endoderm development|blood coagulation|transcription factor binding|zinc ion binding|male gonad development|response to mechanical stimulus|negative regulation of autophagy|positive regulation of vascular endothelial growth factor production|negative regulation of cardiac muscle cell apoptotic process|nuclear body|protein kinase binding|positive regulation of BMP signaling pathway|response to vitamin A|activating transcription factor binding|embryonic heart tube anterior/posterior pattern specification|wound healing|response to drug|sequence-specific DNA binding|cell fate commitment|positive regulation of angiogenesis|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|embryonic foregut morphogenesis|NFAT protein binding|positive regulation of cardioblast differentiation|regulation of protein kinase B signaling|transdifferentiation|atrial septum morphogenesis|intestinal epithelial cell differentiation|cardiac muscle tissue regeneration|cell growth involved in cardiac muscle cell development|positive regulation of ERK1 and ERK2 cascade|co-SMAD binding|cellular response to glucose stimulus|regulation of cardiac muscle cell contraction|RNA polymerase II transcription regulator complex|negative regulation of oxidative stress-induced cell death|sequence-specific double-stranded DNA binding|negative regulation of apoptotic signaling pathway" "hsa04022,hsa04218,hsa04530,hsa04919" cGMP-PKG signaling pathway|Cellular senescence|Tight junction|Thyroid hormone signaling pathway zf-GATA GATA6 556.342066 613.8441908 498.8399412 0.81264912 -0.299295526 0.262633224 1 9.039662324 7.223147035 2627 GATA binding protein 6 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001103,GO:0001701,GO:0001889,GO:0001949,GO:0002759,GO:0003148,GO:0003309,GO:0003310,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006644,GO:0007493,GO:0007596,GO:0008134,GO:0008270,GO:0008584,GO:0014898,GO:0019901,GO:0030855,GO:0031965,GO:0032526,GO:0032911,GO:0032912,GO:0035239,GO:0042493,GO:0043066,GO:0043627,GO:0044267,GO:0045165,GO:0045766,GO:0045892,GO:0045893,GO:0045944,GO:0048645,GO:0051145,GO:0051891,GO:0055007,GO:0060045,GO:0060430,GO:0060486,GO:0060510,GO:0060575,GO:0060947,GO:0070848,GO:0071158,GO:0071371,GO:0071456,GO:0071773,GO:0098773,GO:0110024,GO:1901390,GO:1904003,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II repressing transcription factor binding|in utero embryonic development|liver development|sebaceous gland cell differentiation|regulation of antimicrobial humoral response|outflow tract septum morphogenesis|type B pancreatic cell differentiation|pancreatic A cell differentiation|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|phospholipid metabolic process|endodermal cell fate determination|blood coagulation|transcription factor binding|zinc ion binding|male gonad development|cardiac muscle hypertrophy in response to stress|protein kinase binding|epithelial cell differentiation|nuclear membrane|response to retinoic acid|negative regulation of transforming growth factor beta1 production|negative regulation of transforming growth factor beta2 production|tube morphogenesis|response to drug|negative regulation of apoptotic process|response to estrogen|cellular protein metabolic process|cell fate commitment|positive regulation of angiogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|animal organ formation|smooth muscle cell differentiation|positive regulation of cardioblast differentiation|cardiac muscle cell differentiation|positive regulation of cardiac muscle cell proliferation|lung saccule development|club cell differentiation|type II pneumocyte differentiation|intestinal epithelial cell differentiation|cardiac vascular smooth muscle cell differentiation|response to growth factor|positive regulation of cell cycle arrest|cellular response to gonadotropin stimulus|cellular response to hypoxia|cellular response to BMP stimulus|skin epidermis development|positive regulation of cardiac muscle myoblast proliferation|positive regulation of transforming growth factor beta activation|negative regulation of sebum secreting cell proliferation|sequence-specific double-stranded DNA binding" zf-GATA GATAD1 830.4137093 857.3010393 803.5263792 0.937274472 -0.093456505 0.712501393 1 16.80226985 15.48481149 57798 GATA zinc finger domain containing 1 "GO:0005634,GO:0005654,GO:0006325,GO:0006338,GO:0006355,GO:0008270,GO:0043565" "nucleus|nucleoplasm|chromatin organization|chromatin remodeling|regulation of transcription, DNA-templated|zinc ion binding|sequence-specific DNA binding" zf-GATA GATAD2A 1535.49153 1578.30786 1492.6752 0.945744007 -0.080478366 0.737620871 1 11.88198472 11.04927458 54815 GATA zinc finger domain containing 2A "GO:0000122,GO:0005515,GO:0005634,GO:0005654,GO:0006306,GO:0008270,GO:0016581,GO:0016607,GO:0030674,GO:0043565,GO:0045892" "negative regulation of transcription by RNA polymerase II|protein binding|nucleus|nucleoplasm|DNA methylation|zinc ion binding|NuRD complex|nuclear speck|protein-macromolecule adaptor activity|sequence-specific DNA binding|negative regulation of transcription, DNA-templated" GATAD2B 949.5467436 982.1507052 916.942782 0.933607009 -0.099112703 0.691068393 1 6.373489545 5.85076372 57459 GATA zinc finger domain containing 2B "GO:0000122,GO:0000785,GO:0005515,GO:0005654,GO:0008270,GO:0016581,GO:0016607,GO:0031492,GO:0032991,GO:0043044,GO:0043565" negative regulation of transcription by RNA polymerase II|chromatin|protein binding|nucleoplasm|zinc ion binding|NuRD complex|nuclear speck|nucleosomal DNA binding|protein-containing complex|ATP-dependent chromatin remodeling|sequence-specific DNA binding GATB 307.9794437 275.7096789 340.2492084 1.234085106 0.303441891 0.332805224 1 6.211109679 7.53677392 5188 glutamyl-tRNA amidotransferase subunit B "GO:0005515,GO:0005524,GO:0005739,GO:0030956,GO:0032543,GO:0050567,GO:0070681" protein binding|ATP binding|mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex|mitochondrial translation|glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity|glutaminyl-tRNAGln biosynthesis via transamidation hsa00970 Aminoacyl-tRNA biosynthesis GATC 1332.926626 1382.71005 1283.143201 0.92799152 -0.107816473 0.655421459 1 17.41215056 15.88794033 283459 glutamyl-tRNA amidotransferase subunit C "GO:0005515,GO:0005524,GO:0005739,GO:0006450,GO:0030956,GO:0032543,GO:0050567,GO:0070681" protein binding|ATP binding|mitochondrion|regulation of translational fidelity|glutamyl-tRNA(Gln) amidotransferase complex|mitochondrial translation|glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity|glutaminyl-tRNAGln biosynthesis via transamidation hsa00970 Aminoacyl-tRNA biosynthesis GATD1 1314.684784 1332.770184 1296.599385 0.972860438 -0.039695237 0.871898905 1 12.73089228 12.17812886 347862 glutamine amidotransferase like class 1 domain containing 1 "GO:0003674,GO:0008150,GO:0070062" molecular_function|biological_process|extracellular exosome GATD3A 190.6196518 222.6485709 158.5907327 0.712291717 -0.489459882 0.186261305 1 5.483315652 3.840363378 8209 glutamine amidotransferase like class 1 domain containing 3A GO:0005739 mitochondrion GATD3B 168.8653095 143.5771158 194.1535031 1.352259391 0.435371916 0.263340583 1 4.837403275 6.431962132 102724023 glutamine amidotransferase like class 1 domain containing 3B "GO:0005515,GO:0005739" protein binding|mitochondrion GATM 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.056199369 0.017016455 2628 glycine amidinotransferase "GO:0005515,GO:0005739,GO:0005743,GO:0005758,GO:0006600,GO:0006601,GO:0007275,GO:0007611,GO:0014889,GO:0015067,GO:0015068,GO:0070062,GO:0120162" protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|creatine metabolic process|creatine biosynthetic process|multicellular organism development|learning or memory|muscle atrophy|amidinotransferase activity|glycine amidinotransferase activity|extracellular exosome|positive regulation of cold-induced thermogenesis "hsa00260,hsa00330" "Glycine, serine and threonine metabolism|Arginine and proline metabolism" GBA 1080.728212 1221.445898 940.010525 0.769588343 -0.377841148 0.121669663 1 27.01463849 20.44225585 2629 glucosylceramidase beta "GO:0004348,GO:0005102,GO:0005124,GO:0005515,GO:0005764,GO:0005765,GO:0005783,GO:0005794,GO:0005802,GO:0006680,GO:0006687,GO:0006914,GO:0007005,GO:0007040,GO:0008203,GO:0008340,GO:0009267,GO:0009268,GO:0014004,GO:0016241,GO:0019882,GO:0019898,GO:0019915,GO:0021694,GO:0021859,GO:0023021,GO:0030259,GO:0031175,GO:0031333,GO:0032006,GO:0032268,GO:0032436,GO:0032715,GO:0033077,GO:0033561,GO:0033574,GO:0035307,GO:0036473,GO:0043202,GO:0043243,GO:0043407,GO:0043524,GO:0043589,GO:0043627,GO:0046512,GO:0046513,GO:0046527,GO:0048469,GO:0048854,GO:0048872,GO:0050295,GO:0050728,GO:0050905,GO:0051247,GO:0051402,GO:0061518,GO:0061744,GO:0070062,GO:0071356,GO:0071425,GO:0071548,GO:0072676,GO:0097066,GO:1901215,GO:1901805,GO:1903052,GO:1903061,GO:1904457,GO:1904925,GO:1905037,GO:1905165" glucosylceramidase activity|signaling receptor binding|scavenger receptor binding|protein binding|lysosome|lysosomal membrane|endoplasmic reticulum|Golgi apparatus|trans-Golgi network|glucosylceramide catabolic process|glycosphingolipid metabolic process|autophagy|mitochondrion organization|lysosome organization|cholesterol metabolic process|determination of adult lifespan|cellular response to starvation|response to pH|microglia differentiation|regulation of macroautophagy|antigen processing and presentation|extrinsic component of membrane|lipid storage|cerebellar Purkinje cell layer formation|pyramidal neuron differentiation|termination of signal transduction|lipid glycosylation|neuron projection development|negative regulation of protein-containing complex assembly|regulation of TOR signaling|regulation of cellular protein metabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of interleukin-6 production|T cell differentiation in thymus|regulation of water loss via skin|response to testosterone|positive regulation of protein dephosphorylation|cell death in response to oxidative stress|lysosomal lumen|positive regulation of protein-containing complex disassembly|negative regulation of MAP kinase activity|negative regulation of neuron apoptotic process|skin morphogenesis|response to estrogen|sphingosine biosynthetic process|ceramide biosynthetic process|glucosyltransferase activity|cell maturation|brain morphogenesis|homeostasis of number of cells|steryl-beta-glucosidase activity|negative regulation of inflammatory response|neuromuscular process|positive regulation of protein metabolic process|neuron apoptotic process|microglial cell proliferation|motor behavior|extracellular exosome|cellular response to tumor necrosis factor|hematopoietic stem cell proliferation|response to dexamethasone|lymphocyte migration|response to thyroid hormone|negative regulation of neuron death|beta-glucoside catabolic process|positive regulation of proteolysis involved in cellular protein catabolic process|positive regulation of protein lipidation|positive regulation of neuronal action potential|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization|autophagosome organization|regulation of lysosomal protein catabolic process "hsa00511,hsa00600,hsa04142" Other glycan degradation|Sphingolipid metabolism|Lysosome GBA2 1148.490321 1120.525752 1176.45489 1.0499133 0.070270198 0.775299594 1 17.15444634 17.70929701 57704 glucosylceramidase beta 2 "GO:0004348,GO:0005790,GO:0005829,GO:0005886,GO:0005975,GO:0006680,GO:0006687,GO:0007417,GO:0008203,GO:0008206,GO:0008422,GO:0016021,GO:0016139,GO:0019898,GO:0021954,GO:0030259,GO:0030833,GO:0031113,GO:0042406,GO:0046527,GO:0050295,GO:0090498,GO:0097035" glucosylceramidase activity|smooth endoplasmic reticulum|cytosol|plasma membrane|carbohydrate metabolic process|glucosylceramide catabolic process|glycosphingolipid metabolic process|central nervous system development|cholesterol metabolic process|bile acid metabolic process|beta-glucosidase activity|integral component of membrane|glycoside catabolic process|extrinsic component of membrane|central nervous system neuron development|lipid glycosylation|regulation of actin filament polymerization|regulation of microtubule polymerization|extrinsic component of endoplasmic reticulum membrane|glucosyltransferase activity|steryl-beta-glucosidase activity|extrinsic component of Golgi membrane|regulation of membrane lipid distribution "hsa00511,hsa00600" Other glycan degradation|Sphingolipid metabolism GBE1 1758.817479 1435.771158 2081.863801 1.44999695 0.536049866 0.024026054 0.848442542 26.05388231 37.14588539 2632 "1,4-alpha-glucan branching enzyme 1" "GO:0003844,GO:0004553,GO:0005515,GO:0005737,GO:0005829,GO:0005975,GO:0005977,GO:0005978,GO:0006091,GO:0030246,GO:0043169,GO:0043524,GO:0070062,GO:0102752" "1,4-alpha-glucan branching enzyme activity|hydrolase activity, hydrolyzing O-glycosyl compounds|protein binding|cytoplasm|cytosol|carbohydrate metabolic process|glycogen metabolic process|glycogen biosynthetic process|generation of precursor metabolites and energy|carbohydrate binding|cation binding|negative regulation of neuron apoptotic process|extracellular exosome|1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)" hsa00500 Starch and sucrose metabolism GBF1 5684.275288 5866.893884 5501.656692 0.937746072 -0.092730781 0.701339139 1 46.18072916 42.58113348 8729 golgi brefeldin A resistant guanine nucleotide exchange factor 1 "GO:0000139,GO:0002263,GO:0005085,GO:0005515,GO:0005547,GO:0005793,GO:0005794,GO:0005801,GO:0005802,GO:0005811,GO:0005829,GO:0006888,GO:0006890,GO:0006892,GO:0006895,GO:0007030,GO:0007346,GO:0015031,GO:0016020,GO:0016032,GO:0030593,GO:0031252,GO:0032012,GO:0034067,GO:0042147,GO:0048205,GO:0050790,GO:0061162,GO:0070973,GO:0080025,GO:0090166,GO:0097111,GO:0098586,GO:1903409,GO:1903420,GO:2000008" "Golgi membrane|cell activation involved in immune response|guanyl-nucleotide exchange factor activity|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|trans-Golgi network|lipid droplet|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|post-Golgi vesicle-mediated transport|Golgi to endosome transport|Golgi organization|regulation of mitotic cell cycle|protein transport|membrane|viral process|neutrophil chemotaxis|cell leading edge|regulation of ARF protein signal transduction|protein localization to Golgi apparatus|retrograde transport, endosome to Golgi|COPI coating of Golgi vesicle|regulation of catalytic activity|establishment of monopolar cell polarity|protein localization to endoplasmic reticulum exit site|phosphatidylinositol-3,5-bisphosphate binding|Golgi disassembly|endoplasmic reticulum-Golgi intermediate compartment organization|cellular response to virus|reactive oxygen species biosynthetic process|protein localization to endoplasmic reticulum tubular network|regulation of protein localization to cell surface" hsa04144 Endocytosis GBGT1 8.407599406 6.242483296 10.57271552 1.693671415 0.760154008 0.593857288 1 0.167327906 0.278656201 26301 "globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)" "GO:0000139,GO:0005794,GO:0005975,GO:0006486,GO:0009247,GO:0016021,GO:0016757,GO:0030259,GO:0031982,GO:0046872,GO:0047277" "Golgi membrane|Golgi apparatus|carbohydrate metabolic process|protein glycosylation|glycolipid biosynthetic process|integral component of membrane|transferase activity, transferring glycosyl groups|lipid glycosylation|vesicle|metal ion binding|globoside alpha-N-acetylgalactosaminyltransferase activity" hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series GBP1 359.2522179 347.4982368 371.006199 1.067649155 0.094437635 0.758919015 1 6.50942163 6.833483374 2633 guanylate binding protein 1 "GO:0000139,GO:0003779,GO:0003924,GO:0005515,GO:0005525,GO:0005576,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0012506,GO:0015629,GO:0019003,GO:0019899,GO:0019955,GO:0030507,GO:0031410,GO:0032703,GO:0042802,GO:0042803,GO:0050848,GO:0050860,GO:0051607,GO:0051879,GO:0060333,GO:0070373,GO:0071346,GO:0071347,GO:0071356,GO:0072665,GO:1900025,GO:1903076,GO:1903077" Golgi membrane|actin binding|GTPase activity|protein binding|GTP binding|extracellular region|cytoplasm|Golgi apparatus|cytosol|plasma membrane|vesicle membrane|actin cytoskeleton|GDP binding|enzyme binding|cytokine binding|spectrin binding|cytoplasmic vesicle|negative regulation of interleukin-2 production|identical protein binding|protein homodimerization activity|regulation of calcium-mediated signaling|negative regulation of T cell receptor signaling pathway|defense response to virus|Hsp90 protein binding|interferon-gamma-mediated signaling pathway|negative regulation of ERK1 and ERK2 cascade|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to tumor necrosis factor|protein localization to vacuole|negative regulation of substrate adhesion-dependent cell spreading|regulation of protein localization to plasma membrane|negative regulation of protein localization to plasma membrane hsa04621 NOD-like receptor signaling pathway GBP2 524.4169425 431.7717613 617.0621237 1.429139604 0.515146851 0.056771162 1 5.636708742 7.920843409 2634 guanylate binding protein 2 "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006955,GO:0031410,GO:0034504,GO:0042803,GO:0042832,GO:0048471,GO:0050830,GO:0060333,GO:0060337,GO:0071346,GO:0071347,GO:0071356" Golgi membrane|GTPase activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|immune response|cytoplasmic vesicle|protein localization to nucleus|protein homodimerization activity|defense response to protozoan|perinuclear region of cytoplasm|defense response to Gram-positive bacterium|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to tumor necrosis factor hsa04621 NOD-like receptor signaling pathway GBP3 914.1883772 773.0275148 1055.34924 1.365215622 0.449128829 0.070127033 1 12.23822536 16.42823377 2635 guanylate binding protein 3 "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005829,GO:0031410,GO:0042803,GO:0048471,GO:0051607,GO:0071346,GO:0071347,GO:0071356" Golgi membrane|GTPase activity|protein binding|GTP binding|cytoplasm|cytosol|cytoplasmic vesicle|protein homodimerization activity|perinuclear region of cytoplasm|defense response to virus|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to tumor necrosis factor hsa04621 NOD-like receptor signaling pathway GBP4 12.88628664 22.88910542 2.883467868 0.12597556 -2.988784228 0.008833988 0.578013326 0.198917031 0.024639361 115361 guanylate binding protein 4 "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005794,GO:0005829,GO:0005886,GO:0031410,GO:0042803,GO:0042832,GO:0048471,GO:0050830,GO:0071346" Golgi membrane|GTPase activity|protein binding|GTP binding|nucleus|Golgi apparatus|cytosol|plasma membrane|cytoplasmic vesicle|protein homodimerization activity|defense response to protozoan|perinuclear region of cytoplasm|defense response to Gram-positive bacterium|cellular response to interferon-gamma hsa04621 NOD-like receptor signaling pathway GBP5 7.644588267 11.44455271 3.844623824 0.335934826 -1.573746729 0.246344754 1 0.089661589 0.029616425 115362 guanylate binding protein 5 "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005794,GO:0006954,GO:0016020,GO:0031410,GO:0032611,GO:0032621,GO:0034067,GO:0042802,GO:0042803,GO:0045089,GO:0048471,GO:0051289,GO:0071346,GO:1900017,GO:1900227" Golgi membrane|GTPase activity|protein binding|GTP binding|cytoplasm|Golgi apparatus|inflammatory response|membrane|cytoplasmic vesicle|interleukin-1 beta production|interleukin-18 production|protein localization to Golgi apparatus|identical protein binding|protein homodimerization activity|positive regulation of innate immune response|perinuclear region of cytoplasm|protein homotetramerization|cellular response to interferon-gamma|positive regulation of cytokine production involved in inflammatory response|positive regulation of NLRP3 inflammasome complex assembly hsa04621 NOD-like receptor signaling pathway GBX2 41.95370868 41.61655531 42.29086206 1.016202849 0.023188414 1 1 1.020210872 1.019392735 2637 gastrulation brain homeobox 2 "GO:0000785,GO:0000977,GO:0000979,GO:0000981,GO:0001085,GO:0001228,GO:0001569,GO:0001755,GO:0003700,GO:0005634,GO:0006357,GO:0007399,GO:0007411,GO:0021549,GO:0021555,GO:0021568,GO:0021794,GO:0021884,GO:0021930,GO:0042472,GO:0045944,GO:0048483,GO:0051960,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|branching involved in blood vessel morphogenesis|neural crest cell migration|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|nervous system development|axon guidance|cerebellum development|midbrain-hindbrain boundary morphogenesis|rhombomere 2 development|thalamus development|forebrain neuron development|cerebellar granule cell precursor proliferation|inner ear morphogenesis|positive regulation of transcription by RNA polymerase II|autonomic nervous system development|regulation of nervous system development|sequence-specific double-stranded DNA binding" GCA 597.9447588 532.6919079 663.1976096 1.244992837 0.316137442 0.230007114 1 5.659722891 6.928403928 25801 grancalcin "GO:0005509,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0005886,GO:0035578,GO:0042803,GO:0043312,GO:0046982,GO:0061025,GO:0070062" calcium ion binding|protein binding|extracellular region|cytoplasm|cytosol|plasma membrane|azurophil granule lumen|protein homodimerization activity|neutrophil degranulation|protein heterodimerization activity|membrane fusion|extracellular exosome GCAT 91.94326485 117.5667687 66.31976096 0.564102949 -0.825969616 0.086371474 1 3.034005014 1.682851689 23464 glycine C-acetyltransferase "GO:0005654,GO:0005739,GO:0005743,GO:0006520,GO:0008890,GO:0009058,GO:0016607,GO:0019518,GO:0030170" nucleoplasm|mitochondrion|mitochondrial inner membrane|cellular amino acid metabolic process|glycine C-acetyltransferase activity|biosynthetic process|nuclear speck|L-threonine catabolic process to glycine|pyridoxal phosphate binding hsa00260 "Glycine, serine and threonine metabolism" GCC1 421.3549887 476.5095583 366.2004192 0.768505926 -0.379871711 0.182848971 1 6.160474645 4.655138147 79571 GRIP and coiled-coil domain containing 1 "GO:0000138,GO:0000139,GO:0005515,GO:0005794,GO:0005829,GO:0031267" Golgi trans cisterna|Golgi membrane|protein binding|Golgi apparatus|cytosol|small GTPase binding GCC2 1011.872811 1053.939263 969.8063596 0.920172911 -0.12002311 0.627234804 1 6.869418834 6.215278861 9648 GRIP and coiled-coil domain containing 2 "GO:0005515,GO:0005654,GO:0005794,GO:0005802,GO:0005829,GO:0006622,GO:0016020,GO:0031023,GO:0031267,GO:0034067,GO:0034453,GO:0034499,GO:0042147,GO:0042802,GO:0043001,GO:0070861,GO:0071955,GO:0090161" "protein binding|nucleoplasm|Golgi apparatus|trans-Golgi network|cytosol|protein targeting to lysosome|membrane|microtubule organizing center organization|small GTPase binding|protein localization to Golgi apparatus|microtubule anchoring|late endosome to Golgi transport|retrograde transport, endosome to Golgi|identical protein binding|Golgi to plasma membrane protein transport|regulation of protein exit from endoplasmic reticulum|recycling endosome to Golgi transport|Golgi ribbon formation" hsa05132 Salmonella infection GCDH 158.5253373 162.3045657 154.7461089 0.953430412 -0.068800451 0.878039418 1 4.677049875 4.384622219 2639 glutaryl-CoA dehydrogenase "GO:0000062,GO:0004361,GO:0005739,GO:0005759,GO:0006554,GO:0006568,GO:0033539,GO:0046949,GO:0050660" fatty-acyl-CoA binding|glutaryl-CoA dehydrogenase activity|mitochondrion|mitochondrial matrix|lysine catabolic process|tryptophan metabolic process|fatty acid beta-oxidation using acyl-CoA dehydrogenase|fatty-acyl-CoA biosynthetic process|flavin adenine dinucleotide binding "hsa00071,hsa00310,hsa00380" Fatty acid degradation|Lysine degradation|Tryptophan metabolism GCFC2 514.2348718 555.5810133 472.8887303 0.851160711 -0.232496536 0.393491548 1 2.817937423 2.358381677 6936 GC-rich sequence DNA-binding factor 2 "GO:0000245,GO:0000398,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006355,GO:0045892,GO:0071008" "spliceosomal complex assembly|mRNA splicing, via spliceosome|DNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|U2-type post-mRNA release spliceosomal complex" GCH1 426.5029523 422.4080364 430.5978683 1.019388438 0.027703895 0.931134489 1 5.850802114 5.864436548 2643 GTP cyclohydrolase 1 "GO:0003924,GO:0003934,GO:0005509,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006729,GO:0006809,GO:0008217,GO:0008270,GO:0010460,GO:0014916,GO:0030742,GO:0031369,GO:0031410,GO:0031965,GO:0032496,GO:0032991,GO:0034341,GO:0034612,GO:0035998,GO:0042311,GO:0042416,GO:0042559,GO:0042802,GO:0042803,GO:0044306,GO:0044877,GO:0045776,GO:0046654,GO:0048265,GO:0050884,GO:0051000,GO:0051019,GO:0065003,GO:2000121" "GTPase activity|GTP cyclohydrolase I activity|calcium ion binding|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|cytosol|tetrahydrobiopterin biosynthetic process|nitric oxide biosynthetic process|regulation of blood pressure|zinc ion binding|positive regulation of heart rate|regulation of lung blood pressure|GTP-dependent protein binding|translation initiation factor binding|cytoplasmic vesicle|nuclear membrane|response to lipopolysaccharide|protein-containing complex|response to interferon-gamma|response to tumor necrosis factor|7,8-dihydroneopterin 3'-triphosphate biosynthetic process|vasodilation|dopamine biosynthetic process|pteridine-containing compound biosynthetic process|identical protein binding|protein homodimerization activity|neuron projection terminus|protein-containing complex binding|negative regulation of blood pressure|tetrahydrofolate biosynthetic process|response to pain|neuromuscular process controlling posture|positive regulation of nitric-oxide synthase activity|mitogen-activated protein kinase binding|protein-containing complex assembly|regulation of removal of superoxide radicals" hsa00790 Folate biosynthesis GCHFR 81.06860888 71.7885579 90.34865986 1.258538443 0.331749285 0.520823918 1 5.269908382 6.521398352 2644 GTP cyclohydrolase I feedback regulator "GO:0004857,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006809,GO:0009890,GO:0016597,GO:0030425,GO:0030742,GO:0031965,GO:0032991,GO:0042133,GO:0042470,GO:0043105,GO:0044549,GO:0044877,GO:0065003" enzyme inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|nitric oxide biosynthetic process|negative regulation of biosynthetic process|amino acid binding|dendrite|GTP-dependent protein binding|nuclear membrane|protein-containing complex|neurotransmitter metabolic process|melanosome|negative regulation of GTP cyclohydrolase I activity|GTP cyclohydrolase binding|protein-containing complex binding|protein-containing complex assembly GCKR 8.288712516 3.121241648 13.45618338 4.311163601 2.108077311 0.114110202 1 0.074496838 0.315793745 2646 glucokinase regulator "GO:0004857,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005975,GO:0006110,GO:0006606,GO:0009750,GO:0019899,GO:0030246,GO:0033132,GO:0042593,GO:0046415,GO:0070095,GO:0070328,GO:1901135" enzyme inhibitor activity|protein binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|carbohydrate metabolic process|regulation of glycolytic process|protein import into nucleus|response to fructose|enzyme binding|carbohydrate binding|negative regulation of glucokinase activity|glucose homeostasis|urate metabolic process|fructose-6-phosphate binding|triglyceride homeostasis|carbohydrate derivative metabolic process GCLC 473.7027754 563.9043244 383.5012264 0.680082081 -0.556219215 0.044381047 1 8.753501274 5.853482307 2729 glutamate-cysteine ligase catalytic subunit "GO:0000287,GO:0004357,GO:0005515,GO:0005524,GO:0005829,GO:0006534,GO:0006536,GO:0006750,GO:0006979,GO:0009408,GO:0009725,GO:0016595,GO:0017109,GO:0043066,GO:0043531,GO:0045454,GO:0045892,GO:0097746" "magnesium ion binding|glutamate-cysteine ligase activity|protein binding|ATP binding|cytosol|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|response to oxidative stress|response to heat|response to hormone|glutamate binding|glutamate-cysteine ligase complex|negative regulation of apoptotic process|ADP binding|cell redox homeostasis|negative regulation of transcription, DNA-templated|blood vessel diameter maintenance" "hsa00270,hsa00480,hsa04216" Cysteine and methionine metabolism|Glutathione metabolism|Ferroptosis GCLM 1319.450935 1331.72977 1307.1721 0.98155957 -0.026852269 0.914284351 1 11.13980724 10.75141229 2730 glutamate-cysteine ligase modifier subunit "GO:0004357,GO:0005515,GO:0005829,GO:0006534,GO:0006536,GO:0006750,GO:0006979,GO:0007568,GO:0007584,GO:0008637,GO:0014823,GO:0017109,GO:0030234,GO:0035226,GO:0035229,GO:0035729,GO:0035733,GO:0042493,GO:0043524,GO:0044344,GO:0044752,GO:0044877,GO:0051409,GO:0051900,GO:0071333,GO:0071372,GO:0097069,GO:0097746,GO:1990830,GO:2001237" glutamate-cysteine ligase activity|protein binding|cytosol|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|response to oxidative stress|aging|response to nutrient|apoptotic mitochondrial changes|response to activity|glutamate-cysteine ligase complex|enzyme regulator activity|glutamate-cysteine ligase catalytic subunit binding|positive regulation of glutamate-cysteine ligase activity|cellular response to hepatocyte growth factor stimulus|hepatic stellate cell activation|response to drug|negative regulation of neuron apoptotic process|cellular response to fibroblast growth factor stimulus|response to human chorionic gonadotropin|protein-containing complex binding|response to nitrosative stress|regulation of mitochondrial depolarization|cellular response to glucose stimulus|cellular response to follicle-stimulating hormone stimulus|cellular response to thyroxine stimulus|blood vessel diameter maintenance|cellular response to leukemia inhibitory factor|negative regulation of extrinsic apoptotic signaling pathway "hsa00270,hsa00480,hsa04216" Cysteine and methionine metabolism|Glutathione metabolism|Ferroptosis GCN1 3218.850779 3430.244571 3007.456986 0.876747102 -0.189767338 0.423437408 1 21.08810601 18.17954852 10985 GCN1 activator of EIF2AK4 "GO:0003723,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006417,GO:0008135,GO:0016020,GO:0019887,GO:0019901,GO:0033674,GO:0034198,GO:0036003,GO:0043022,GO:0045296,GO:0045859,GO:1990253" "RNA binding|cytoplasm|cytosol|ribosome|polysome|translation|regulation of translation|translation factor activity, RNA binding|membrane|protein kinase regulator activity|protein kinase binding|positive regulation of kinase activity|cellular response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to stress|ribosome binding|cadherin binding|regulation of protein kinase activity|cellular response to leucine starvation" GCNA 20.33273009 29.13158871 11.53387147 0.395923188 -1.336707531 0.116858155 1 0.361557988 0.140753783 93953 germ cell nuclear acidic peptidase "GO:0005634,GO:0005654" nucleus|nucleoplasm GCNT1 152.0601715 106.122216 197.9981269 1.865755676 0.899760075 0.026234921 0.866576205 0.846695713 1.553292735 2650 glucosaminyl (N-acetyl) transferase 1 "GO:0000139,GO:0003829,GO:0005515,GO:0005615,GO:0005802,GO:0009101,GO:0016021,GO:0016266,GO:0018215,GO:0031985,GO:0032868,GO:0048729,GO:0050901,GO:0060352,GO:0060993" "Golgi membrane|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|protein binding|extracellular space|trans-Golgi network|glycoprotein biosynthetic process|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|Golgi cisterna|response to insulin|tissue morphogenesis|leukocyte tethering or rolling|cell adhesion molecule production|kidney morphogenesis" hsa00512 Mucin type O-glycan biosynthesis GCNT2 984.3068739 986.3123607 982.301387 0.995933364 -0.005878878 0.985616138 1 5.168664368 5.061506417 2651 glucosaminyl (N-acetyl) transferase 2 (I blood group) "GO:0000139,GO:0005794,GO:0006024,GO:0006486,GO:0007179,GO:0007275,GO:0008109,GO:0008284,GO:0010608,GO:0010718,GO:0010812,GO:0016020,GO:0016021,GO:0030335,GO:0034116,GO:0036438,GO:0051897,GO:0070374" "Golgi membrane|Golgi apparatus|glycosaminoglycan biosynthetic process|protein glycosylation|transforming growth factor beta receptor signaling pathway|multicellular organism development|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity|positive regulation of cell population proliferation|posttranscriptional regulation of gene expression|positive regulation of epithelial to mesenchymal transition|negative regulation of cell-substrate adhesion|membrane|integral component of membrane|positive regulation of cell migration|positive regulation of heterotypic cell-cell adhesion|maintenance of lens transparency|positive regulation of protein kinase B signaling|positive regulation of ERK1 and ERK2 cascade" hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series GCNT3 6.202854333 11.44455271 0.961155956 0.083983707 -3.573746729 0.041121017 1 0.123788963 0.010222289 9245 "glucosaminyl (N-acetyl) transferase 3, mucin type" "GO:0000139,GO:0003829,GO:0005975,GO:0006493,GO:0008109,GO:0016020,GO:0016021,GO:0016266,GO:0018215,GO:0048729,GO:0050892,GO:0060993,GO:0070062,GO:0106325,GO:0106326" "Golgi membrane|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|carbohydrate metabolic process|protein O-linked glycosylation|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity|membrane|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|tissue morphogenesis|intestinal absorption|kidney morphogenesis|extracellular exosome|acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity" hsa00512 Mucin type O-glycan biosynthesis GCNT4 11.00863411 11.44455271 10.57271552 0.923820772 -0.11431511 1 1 0.121595609 0.110452816 51301 glucosaminyl (N-acetyl) transferase 4 "GO:0000139,GO:0002121,GO:0003829,GO:0005975,GO:0006493,GO:0008109,GO:0016021,GO:0016266,GO:0018215,GO:0042403,GO:0048729,GO:0048872,GO:0060993" "Golgi membrane|inter-male aggressive behavior|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|carbohydrate metabolic process|protein O-linked glycosylation|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|thyroid hormone metabolic process|tissue morphogenesis|homeostasis of number of cells|kidney morphogenesis" hsa00512 Mucin type O-glycan biosynthesis GCSH 286.7497243 286.1138177 287.3856308 1.00444513 0.006398756 0.996603003 1 9.14881282 9.035706972 2653 glycine cleavage system protein H "GO:0004047,GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0005960,GO:0006546,GO:0009249,GO:0019464" aminomethyltransferase activity|protein binding|cytoplasm|mitochondrion|mitochondrial matrix|glycine cleavage complex|glycine catabolic process|protein lipoylation|glycine decarboxylation via glycine cleavage system "hsa00260,hsa00630" "Glycine, serine and threonine metabolism|Glyoxylate and dicarboxylate metabolism" GDA 805.943247 959.2615998 652.6248941 0.680340894 -0.555670286 0.027104086 0.873268385 9.531563681 6.376199671 9615 guanine deaminase "GO:0005622,GO:0005829,GO:0006139,GO:0006147,GO:0006195,GO:0007399,GO:0008270,GO:0008892,GO:0019239,GO:0046098" intracellular anatomical structure|cytosol|nucleobase-containing compound metabolic process|guanine catabolic process|purine nucleotide catabolic process|nervous system development|zinc ion binding|guanine deaminase activity|deaminase activity|guanine metabolic process hsa00230 Purine metabolism GDAP1 708.5506925 749.0979955 668.0033894 0.891743662 -0.165299039 0.520268969 1 8.866263747 7.774131025 54332 ganglioside induced differentiation associated protein 1 "GO:0000266,GO:0005515,GO:0005634,GO:0005739,GO:0005829,GO:0006626,GO:0006749,GO:0008053,GO:0016020,GO:0031307" mitochondrial fission|protein binding|nucleus|mitochondrion|cytosol|protein targeting to mitochondrion|glutathione metabolic process|mitochondrial fusion|membrane|integral component of mitochondrial outer membrane GDAP2 501.9732022 473.3883166 530.5580877 1.120767178 0.164486612 0.550403862 1 2.49741641 2.752184494 54834 ganglioside induced differentiation associated protein 2 "GO:0005515,GO:0005765,GO:0032526" protein binding|lysosomal membrane|response to retinoic acid GDE1 1503.416723 1568.944135 1437.88931 0.916469413 -0.125841363 0.599266074 1 28.80346229 25.95576589 51573 glycerophosphodiester phosphodiesterase 1 "GO:0004622,GO:0005515,GO:0005886,GO:0006580,GO:0006629,GO:0006644,GO:0008889,GO:0016021,GO:0030659,GO:0046475,GO:0046872,GO:0047395,GO:0070291" lysophospholipase activity|protein binding|plasma membrane|ethanolamine metabolic process|lipid metabolic process|phospholipid metabolic process|glycerophosphodiester phosphodiesterase activity|integral component of membrane|cytoplasmic vesicle membrane|glycerophospholipid catabolic process|metal ion binding|glycerophosphoinositol glycerophosphodiesterase activity|N-acylethanolamine metabolic process GDF11 173.3289054 197.6786377 148.9791732 0.753643261 -0.408046313 0.289452491 1 6.585359286 4.87996237 10220 growth differentiation factor 11 "GO:0001501,GO:0001656,GO:0001657,GO:0005125,GO:0005515,GO:0005615,GO:0005654,GO:0007399,GO:0007498,GO:0008083,GO:0008285,GO:0010862,GO:0021512,GO:0031016,GO:0032991,GO:0043231,GO:0045665,GO:0048469,GO:0048593,GO:0060021,GO:0060395" skeletal system development|metanephros development|ureteric bud development|cytokine activity|protein binding|extracellular space|nucleoplasm|nervous system development|mesoderm development|growth factor activity|negative regulation of cell population proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|spinal cord anterior/posterior patterning|pancreas development|protein-containing complex|intracellular membrane-bounded organelle|negative regulation of neuron differentiation|cell maturation|camera-type eye morphogenesis|roof of mouth development|SMAD protein signal transduction hsa04060 Cytokine-cytokine receptor interaction GDF15 419.8579202 613.8441908 225.8716497 0.367962511 -1.442369308 7.01E-07 0.000563628 19.0574382 6.895079409 9518 growth differentiation factor 15 "GO:0000187,GO:0002023,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005794,GO:0007165,GO:0007179,GO:0007267,GO:0008083,GO:0010862,GO:0030509,GO:0035860,GO:0040015,GO:0042803,GO:0043410,GO:0051897,GO:0060395,GO:0060400,GO:0062023,GO:0070062,GO:0070700,GO:1901741" activation of MAPK activity|reduction of food intake in response to dietary excess|cytokine activity|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|Golgi apparatus|signal transduction|transforming growth factor beta receptor signaling pathway|cell-cell signaling|growth factor activity|positive regulation of pathway-restricted SMAD protein phosphorylation|BMP signaling pathway|glial cell-derived neurotrophic factor receptor signaling pathway|negative regulation of multicellular organism growth|protein homodimerization activity|positive regulation of MAPK cascade|positive regulation of protein kinase B signaling|SMAD protein signal transduction|negative regulation of growth hormone receptor signaling pathway|collagen-containing extracellular matrix|extracellular exosome|BMP receptor binding|positive regulation of myoblast fusion hsa04060 Cytokine-cytokine receptor interaction GDF5 5.04355356 6.242483296 3.844623824 0.615880514 -0.699277611 0.760739355 1 0.126480585 0.076593428 8200 growth differentiation factor 5 "GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0007179,GO:0007267,GO:0008083,GO:0009612,GO:0010862,GO:0030326,GO:0030509,GO:0030513,GO:0032331,GO:0032332,GO:0035136,GO:0035137,GO:0036122,GO:0040014,GO:0042802,GO:0043524,GO:0043932,GO:0045666,GO:0050680,GO:0060390,GO:0060395,GO:0060591,GO:2001054" cytokine activity|protein binding|extracellular region|extracellular space|plasma membrane|transforming growth factor beta receptor signaling pathway|cell-cell signaling|growth factor activity|response to mechanical stimulus|positive regulation of pathway-restricted SMAD protein phosphorylation|embryonic limb morphogenesis|BMP signaling pathway|positive regulation of BMP signaling pathway|negative regulation of chondrocyte differentiation|positive regulation of chondrocyte differentiation|forelimb morphogenesis|hindlimb morphogenesis|BMP binding|regulation of multicellular organism growth|identical protein binding|negative regulation of neuron apoptotic process|ossification involved in bone remodeling|positive regulation of neuron differentiation|negative regulation of epithelial cell proliferation|regulation of SMAD protein signal transduction|SMAD protein signal transduction|chondroblast differentiation|negative regulation of mesenchymal cell apoptotic process "hsa04060,hsa04350,hsa04390" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway GDF7 11.52884105 12.48496659 10.57271552 0.846835707 -0.239845992 0.903809209 1 0.071900261 0.059868835 151449 growth differentiation factor 7 "GO:0005125,GO:0005515,GO:0005615,GO:0007411,GO:0008083,GO:0010862,GO:0021509,GO:0021527,GO:0022612,GO:0030509,GO:0030855,GO:0030901,GO:0032924,GO:0042802,GO:0045165,GO:0045666,GO:0045893,GO:0048608,GO:0048754,GO:0048853,GO:0060389,GO:0060395,GO:0060571,GO:2001051" "cytokine activity|protein binding|extracellular space|axon guidance|growth factor activity|positive regulation of pathway-restricted SMAD protein phosphorylation|roof plate formation|spinal cord association neuron differentiation|gland morphogenesis|BMP signaling pathway|epithelial cell differentiation|midbrain development|activin receptor signaling pathway|identical protein binding|cell fate commitment|positive regulation of neuron differentiation|positive regulation of transcription, DNA-templated|reproductive structure development|branching morphogenesis of an epithelial tube|forebrain morphogenesis|pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction|morphogenesis of an epithelial fold|positive regulation of tendon cell differentiation" "hsa04060,hsa04350,hsa04360,hsa04390" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Axon guidance|Hippo signaling pathway GDF9 20.29813155 15.60620824 24.99005486 1.601289338 0.679234013 0.441168313 1 0.422993728 0.666001057 2661 growth differentiation factor 9 "GO:0001555,GO:0005125,GO:0005615,GO:0005737,GO:0007179,GO:0007292,GO:0008083,GO:0008284,GO:0010862,GO:0030308,GO:0030509,GO:0060395,GO:0070698,GO:2000870" oocyte growth|cytokine activity|extracellular space|cytoplasm|transforming growth factor beta receptor signaling pathway|female gamete generation|growth factor activity|positive regulation of cell population proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of cell growth|BMP signaling pathway|SMAD protein signal transduction|type I activin receptor binding|regulation of progesterone secretion hsa04060 Cytokine-cytokine receptor interaction GDI1 8894.688669 7675.133212 10114.24412 1.317793952 0.39812481 0.10983049 1 182.8606041 236.940248 2664 GDP dissociation inhibitor 1 "GO:0005092,GO:0005093,GO:0005096,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0007165,GO:0015031,GO:0016192,GO:0030424,GO:0030496,GO:0032482,GO:0032991,GO:0043025,GO:0043209,GO:0043547,GO:0045773,GO:0050771,GO:0051056,GO:0051592,GO:0090315" GDP-dissociation inhibitor activity|Rab GDP-dissociation inhibitor activity|GTPase activator activity|protein binding|cytoplasm|Golgi apparatus|cytosol|signal transduction|protein transport|vesicle-mediated transport|axon|midbody|Rab protein signal transduction|protein-containing complex|neuronal cell body|myelin sheath|positive regulation of GTPase activity|positive regulation of axon extension|negative regulation of axonogenesis|regulation of small GTPase mediated signal transduction|response to calcium ion|negative regulation of protein targeting to membrane GDI2 5804.332307 5587.02255 6021.642064 1.0777909 0.108077311 0.655128409 1 71.41775448 75.6853602 2665 GDP dissociation inhibitor 2 "GO:0003723,GO:0005093,GO:0005096,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0005925,GO:0007165,GO:0007264,GO:0015031,GO:0016020,GO:0016192,GO:0031982,GO:0034774,GO:0035578,GO:0043312,GO:0043547,GO:0045202,GO:0051056,GO:0070062" RNA binding|Rab GDP-dissociation inhibitor activity|GTPase activator activity|protein binding|extracellular region|cytoplasm|cytosol|focal adhesion|signal transduction|small GTPase mediated signal transduction|protein transport|membrane|vesicle-mediated transport|vesicle|secretory granule lumen|azurophil granule lumen|neutrophil degranulation|positive regulation of GTPase activity|synapse|regulation of small GTPase mediated signal transduction|extracellular exosome GDPD1 287.6115006 333.9728563 241.250145 0.722364529 -0.469201043 0.1424742 1 6.504933404 4.62030287 284161 glycerophosphodiester phosphodiesterase domain containing 1 "GO:0004622,GO:0005783,GO:0005789,GO:0008081,GO:0016020,GO:0016021,GO:0046475,GO:0046872,GO:0048471,GO:0070291" lysophospholipase activity|endoplasmic reticulum|endoplasmic reticulum membrane|phosphoric diester hydrolase activity|membrane|integral component of membrane|glycerophospholipid catabolic process|metal ion binding|perinuclear region of cytoplasm|N-acylethanolamine metabolic process hsa00565 Ether lipid metabolism GDPD3 21.21965854 14.56579436 27.87352272 1.913628741 0.936310963 0.268523326 1 0.721103594 1.356833394 79153 glycerophosphodiester phosphodiesterase domain containing 3 "GO:0004622,GO:0005783,GO:0005789,GO:0008081,GO:0016021,GO:0034638,GO:0046475,GO:0046872,GO:0048471,GO:0070062,GO:0070291" lysophospholipase activity|endoplasmic reticulum|endoplasmic reticulum membrane|phosphoric diester hydrolase activity|integral component of membrane|phosphatidylcholine catabolic process|glycerophospholipid catabolic process|metal ion binding|perinuclear region of cytoplasm|extracellular exosome|N-acylethanolamine metabolic process hsa00565 Ether lipid metabolism GDPD5 1102.067986 1037.292641 1166.843331 1.124893096 0.169787902 0.487413041 1 9.894263054 10.94374292 81544 glycerophosphodiester phosphodiesterase domain containing 5 "GO:0004435,GO:0005515,GO:0006629,GO:0007399,GO:0012505,GO:0016021,GO:0030426,GO:0047389,GO:0048471" phosphatidylinositol phospholipase C activity|protein binding|lipid metabolic process|nervous system development|endomembrane system|integral component of membrane|growth cone|glycerophosphocholine phosphodiesterase activity|perinuclear region of cytoplasm GDPGP1 48.87491478 59.30359131 38.44623824 0.648295278 -0.625277029 0.305061372 1 0.603187283 0.384499885 390637 GDP-D-glucose phosphorylase 1 "GO:0000166,GO:0005085,GO:0005737,GO:0006006,GO:0016779,GO:0016787,GO:0050790,GO:0080048" nucleotide binding|guanyl-nucleotide exchange factor activity|cytoplasm|glucose metabolic process|nucleotidyltransferase activity|hydrolase activity|regulation of catalytic activity|GDP-D-glucose phosphorylase activity GEM 588.7685034 645.0566072 532.4803996 0.825478561 -0.276697349 0.295054204 1 14.53165283 11.79483828 2669 GTP binding protein overexpressed in skeletal muscle "GO:0000278,GO:0000287,GO:0003924,GO:0005246,GO:0005515,GO:0005516,GO:0005525,GO:0005634,GO:0005886,GO:0006955,GO:0007165,GO:0007166,GO:0009898,GO:0019003,GO:0030496,GO:0051233,GO:0051276,GO:0051310,GO:0072686,GO:1901842" mitotic cell cycle|magnesium ion binding|GTPase activity|calcium channel regulator activity|protein binding|calmodulin binding|GTP binding|nucleus|plasma membrane|immune response|signal transduction|cell surface receptor signaling pathway|cytoplasmic side of plasma membrane|GDP binding|midbody|spindle midzone|chromosome organization|metaphase plate congression|mitotic spindle|negative regulation of high voltage-gated calcium channel activity GEMIN2 225.419411 227.8506403 222.9881818 0.978659448 -0.031121174 0.942339561 1 8.798820478 8.46695455 8487 gem nuclear organelle associated protein 2 "GO:0000245,GO:0000375,GO:0000387,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005730,GO:0005829,GO:0006397,GO:0008380,GO:0016604,GO:0032797,GO:0034719,GO:0051170,GO:0097504" "spliceosomal complex assembly|RNA splicing, via transesterification reactions|spliceosomal snRNP assembly|protein binding|nucleus|nucleoplasm|spliceosomal complex|nucleolus|cytosol|mRNA processing|RNA splicing|nuclear body|SMN complex|SMN-Sm protein complex|import into nucleus|Gemini of coiled bodies" hsa03013 RNA transport GEMIN4 790.203675 861.4626948 718.9446551 0.834562726 -0.260907608 0.30098952 1 7.37128118 6.048854534 50628 gem nuclear organelle associated protein 4 "GO:0000387,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0015030,GO:0016020,GO:0016604,GO:0030532,GO:0032797,GO:0034719,GO:0043021,GO:0051170,GO:0070062,GO:0097504" spliceosomal snRNP assembly|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|Cajal body|membrane|nuclear body|small nuclear ribonucleoprotein complex|SMN complex|SMN-Sm protein complex|ribonucleoprotein complex binding|import into nucleus|extracellular exosome|Gemini of coiled bodies hsa03013 RNA transport GEMIN5 976.2402295 1127.808649 824.6718102 0.731216072 -0.451630314 0.06671975 1 11.13787468 8.007910934 25929 gem nuclear organelle associated protein 5 "GO:0000340,GO:0000387,GO:0000398,GO:0003723,GO:0003730,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006412,GO:0006417,GO:0016020,GO:0016604,GO:0017069,GO:0030619,GO:0030621,GO:0030622,GO:0032797,GO:0034718,GO:0034719,GO:0043022,GO:0051170,GO:0065003,GO:0097504" "RNA 7-methylguanosine cap binding|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|mRNA 3'-UTR binding|protein binding|nucleoplasm|cytoplasm|cytosol|translation|regulation of translation|membrane|nuclear body|snRNA binding|U1 snRNA binding|U4 snRNA binding|U4atac snRNA binding|SMN complex|SMN-Gemin2 complex|SMN-Sm protein complex|ribosome binding|import into nucleus|protein-containing complex assembly|Gemini of coiled bodies" hsa03013 RNA transport GEMIN6 236.2695293 235.1335375 237.4055211 1.009662525 0.013873159 0.981639716 1 3.386948647 3.362451491 79833 gem nuclear organelle associated protein 6 "GO:0000245,GO:0000387,GO:0000398,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0016604,GO:0032797,GO:0034719,GO:0051170,GO:0097504" "spliceosomal complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|protein binding|nucleoplasm|cytoplasm|cytosol|nuclear body|SMN complex|SMN-Sm protein complex|import into nucleus|Gemini of coiled bodies" hsa03013 RNA transport GEMIN7 180.2702332 165.4258073 195.1146591 1.179469287 0.238137852 0.535710789 1 5.703146833 6.614124541 79760 gem nuclear organelle associated protein 7 "GO:0000387,GO:0000398,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0016604,GO:0032797,GO:0034719,GO:0051170,GO:0097504,GO:0120114" "spliceosomal snRNP assembly|mRNA splicing, via spliceosome|protein binding|nucleoplasm|cytoplasm|cytosol|nuclear body|SMN complex|SMN-Sm protein complex|import into nucleus|Gemini of coiled bodies|Sm-like protein family complex" hsa03013 RNA transport GEMIN8 266.362274 293.3967149 239.327833 0.815714086 -0.29386453 0.372512829 1 2.297585243 1.842810905 54960 gem nuclear organelle associated protein 8 "GO:0000387,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0032797,GO:0034719,GO:0051170,GO:0097504" spliceosomal snRNP assembly|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|SMN complex|SMN-Sm protein complex|import into nucleus|Gemini of coiled bodies hsa03013 RNA transport GEN1 625.6736281 692.9156458 558.4316104 0.805915718 -0.311299124 0.233081857 1 6.236026053 4.941612941 348654 GEN1 Holliday junction 5' flap endonuclease "GO:0000287,GO:0000400,GO:0000724,GO:0005654,GO:0005813,GO:0008821,GO:0010824,GO:0017108,GO:0031297,GO:0042803,GO:0071139,GO:0071140,GO:0090267,GO:0090305" magnesium ion binding|four-way junction DNA binding|double-strand break repair via homologous recombination|nucleoplasm|centrosome|crossover junction endodeoxyribonuclease activity|regulation of centrosome duplication|5'-flap endonuclease activity|replication fork processing|protein homodimerization activity|resolution of recombination intermediates|resolution of mitotic recombination intermediates|positive regulation of mitotic cell cycle spindle assembly checkpoint|nucleic acid phosphodiester bond hydrolysis GET1 361.9576626 292.356301 431.5590242 1.476140664 0.561830205 0.058942037 1 9.314936393 13.52006614 7485 guided entry of tail-anchored proteins factor 1 "GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0016021,GO:0071816" protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|tail-anchored membrane protein insertion into ER membrane GET3 1010.387032 964.4636692 1056.310396 1.095230883 0.131235032 0.595185509 1 37.73581629 40.63783931 439 "guided entry of tail-anchored proteins factor 3, ATPase" "GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005737,GO:0005789,GO:0006620,GO:0015105,GO:0015700,GO:0016887,GO:0036498,GO:0043529,GO:0046872,GO:0070062,GO:0071816" protein binding|ATP binding|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum membrane|posttranslational protein targeting to endoplasmic reticulum membrane|arsenite transmembrane transporter activity|arsenite transport|ATPase activity|IRE1-mediated unfolded protein response|GET complex|metal ion binding|extracellular exosome|tail-anchored membrane protein insertion into ER membrane GET4 893.3744548 844.8160727 941.9328369 1.114956104 0.156986912 0.529499115 1 21.5723833 23.64977843 51608 guided entry of tail-anchored proteins factor 4 "GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0005829,GO:0045048,GO:0051087,GO:0051220,GO:0071816,GO:0071818,GO:1904378" protein binding|nucleoplasm|chromosome|nucleolus|cytoplasm|cytosol|protein insertion into ER membrane|chaperone binding|cytoplasmic sequestering of protein|tail-anchored membrane protein insertion into ER membrane|BAT3 complex|maintenance of unfolded protein involved in ERAD pathway GFER 462.5016413 433.8525891 491.1506935 1.13206814 0.178960798 0.523848414 1 9.790239024 10.89775504 2671 "growth factor, augmenter of liver regeneration" "GO:0001889,GO:0005515,GO:0005576,GO:0005739,GO:0005758,GO:0005829,GO:0007165,GO:0008083,GO:0015035,GO:0016971,GO:0050660,GO:0055114" liver development|protein binding|extracellular region|mitochondrion|mitochondrial intermembrane space|cytosol|signal transduction|growth factor activity|protein disulfide oxidoreductase activity|flavin-linked sulfhydryl oxidase activity|flavin adenine dinucleotide binding|oxidation-reduction process GFI1 125.0981149 130.0517353 120.1444945 0.923820772 -0.11431511 0.807697925 1 1.119455176 1.016870411 2672 growth factor independent 1 transcriptional repressor "GO:0000083,GO:0000122,GO:0000976,GO:0000978,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0010956,GO:0010957,GO:0010977,GO:0016032,GO:0016363,GO:0016604,GO:0017053,GO:0030097,GO:0032088,GO:0034121,GO:0045892,GO:0046872,GO:0051569,GO:0070105,GO:0071222,GO:1990837" "regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of vitamin D biosynthetic process|negative regulation of neuron projection development|viral process|nuclear matrix|nuclear body|transcription repressor complex|hemopoiesis|negative regulation of NF-kappaB transcription factor activity|regulation of toll-like receptor signaling pathway|negative regulation of transcription, DNA-templated|metal ion binding|regulation of histone H3-K4 methylation|positive regulation of interleukin-6-mediated signaling pathway|cellular response to lipopolysaccharide|sequence-specific double-stranded DNA binding" GFM1 970.1323387 980.0698774 960.1948 0.979720755 -0.029557492 0.908814374 1 13.75710891 13.25258695 85476 G elongation factor mitochondrial 1 "GO:0003723,GO:0003746,GO:0003924,GO:0005515,GO:0005525,GO:0005739,GO:0005759,GO:0070125" RNA binding|translation elongation factor activity|GTPase activity|protein binding|GTP binding|mitochondrion|mitochondrial matrix|mitochondrial translational elongation GFM2 1417.622206 1398.316258 1436.928154 1.027613135 0.039297236 0.872406737 1 17.69216897 17.87647574 84340 GTP dependent ribosome recycling factor mitochondrial 2 "GO:0003746,GO:0003924,GO:0005515,GO:0005525,GO:0005739,GO:0005759,GO:0032543,GO:0032790,GO:0070125,GO:0070126" translation elongation factor activity|GTPase activity|protein binding|GTP binding|mitochondrion|mitochondrial matrix|mitochondrial translation|ribosome disassembly|mitochondrial translational elongation|mitochondrial translational termination GFOD1 321.1330722 330.8516147 311.4145297 0.941251352 -0.087348062 0.7852909 1 1.648640765 1.525818324 54438 glucose-fructose oxidoreductase domain containing 1 "GO:0005515,GO:0005576,GO:0016491,GO:0055114" protein binding|extracellular region|oxidoreductase activity|oxidation-reduction process GFOD2 493.729149 458.8225222 528.6357758 1.152157425 0.204337853 0.458521736 1 3.370013038 3.817812386 81577 glucose-fructose oxidoreductase domain containing 2 "GO:0016491,GO:0030198,GO:0031012,GO:0055114" oxidoreductase activity|extracellular matrix organization|extracellular matrix|oxidation-reduction process GFPT1 2263.666661 2325.325028 2202.008295 0.946967959 -0.078612483 0.740751743 1 14.08447656 13.11436222 2673 glutamine--fructose-6-phosphate transaminase 1 "GO:0004360,GO:0005829,GO:0006002,GO:0006047,GO:0006048,GO:0006112,GO:0006487,GO:0006541,GO:0032922,GO:0036498,GO:0070062,GO:0097367" glutamine-fructose-6-phosphate transaminase (isomerizing) activity|cytosol|fructose 6-phosphate metabolic process|UDP-N-acetylglucosamine metabolic process|UDP-N-acetylglucosamine biosynthetic process|energy reserve metabolic process|protein N-linked glycosylation|glutamine metabolic process|circadian regulation of gene expression|IRE1-mediated unfolded protein response|extracellular exosome|carbohydrate derivative binding "hsa00250,hsa00520,hsa04931" "Alanine, aspartate and glutamate metabolism|Amino sugar and nucleotide sugar metabolism|Insulin resistance" GFPT2 1882.214736 1811.36057 1953.068903 1.078233089 0.108669089 0.647632557 1 31.86189336 33.77967088 9945 glutamine-fructose-6-phosphate transaminase 2 "GO:0004360,GO:0005515,GO:0005829,GO:0006002,GO:0006047,GO:0006048,GO:0006112,GO:0006487,GO:0006541,GO:0097367,GO:1990830" glutamine-fructose-6-phosphate transaminase (isomerizing) activity|protein binding|cytosol|fructose 6-phosphate metabolic process|UDP-N-acetylglucosamine metabolic process|UDP-N-acetylglucosamine biosynthetic process|energy reserve metabolic process|protein N-linked glycosylation|glutamine metabolic process|carbohydrate derivative binding|cellular response to leukemia inhibitory factor "hsa00250,hsa00520,hsa04931" "Alanine, aspartate and glutamate metabolism|Amino sugar and nucleotide sugar metabolism|Insulin resistance" GFRA1 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.02273052 0.010323769 2674 GDNF family receptor alpha 1 "GO:0000165,GO:0005102,GO:0005771,GO:0005794,GO:0005886,GO:0007166,GO:0007399,GO:0007411,GO:0009897,GO:0016167,GO:0019898,GO:0031225,GO:0035860,GO:0038023,GO:0043235,GO:0070062" MAPK cascade|signaling receptor binding|multivesicular body|Golgi apparatus|plasma membrane|cell surface receptor signaling pathway|nervous system development|axon guidance|external side of plasma membrane|glial cell-derived neurotrophic factor receptor activity|extrinsic component of membrane|anchored component of membrane|glial cell-derived neurotrophic factor receptor signaling pathway|signaling receptor activity|receptor complex|extracellular exosome GFRA3 4.042768641 5.202069413 2.883467868 0.554292463 -0.851280704 0.745112452 1 0.139650344 0.07611183 2676 GDNF family receptor alpha 3 "GO:0000165,GO:0001764,GO:0005102,GO:0005515,GO:0005829,GO:0005886,GO:0007165,GO:0007399,GO:0007411,GO:0007422,GO:0008046,GO:0009897,GO:0016167,GO:0019898,GO:0031225,GO:0035860,GO:0038023,GO:0043235,GO:0048485" MAPK cascade|neuron migration|signaling receptor binding|protein binding|cytosol|plasma membrane|signal transduction|nervous system development|axon guidance|peripheral nervous system development|axon guidance receptor activity|external side of plasma membrane|glial cell-derived neurotrophic factor receptor activity|extrinsic component of membrane|anchored component of membrane|glial cell-derived neurotrophic factor receptor signaling pathway|signaling receptor activity|receptor complex|sympathetic nervous system development GFUS 1201.318686 1207.920518 1194.716853 0.989069095 -0.015856786 0.951490971 1 42.10613845 40.94899284 7264 GDP-L-fucose synthase "GO:0005515,GO:0005829,GO:0007159,GO:0009055,GO:0010595,GO:0019673,GO:0022900,GO:0042351,GO:0042356,GO:0042802,GO:0047918,GO:0050577,GO:0070062,GO:1904906" "protein binding|cytosol|leukocyte cell-cell adhesion|electron transfer activity|positive regulation of endothelial cell migration|GDP-mannose metabolic process|electron transport chain|'de novo' GDP-L-fucose biosynthetic process|GDP-4-dehydro-D-rhamnose reductase activity|identical protein binding|GDP-mannose 3,5-epimerase activity|GDP-L-fucose synthase activity|extracellular exosome|positive regulation of endothelial cell-matrix adhesion via fibronectin" "hsa00051,hsa00520" Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism GGA1 1278.057062 1292.194042 1263.920082 0.978119416 -0.031917484 0.897848798 1 16.46657619 15.83676114 26088 "golgi associated, gamma adaptin ear containing, ARF binding protein 1" "GO:0003674,GO:0005515,GO:0005654,GO:0005769,GO:0005794,GO:0005829,GO:0006886,GO:0008104,GO:0010008,GO:0016020,GO:0031267,GO:0031901,GO:0032991,GO:0034394,GO:0042147,GO:0043001,GO:0043231,GO:0044267,GO:0045732,GO:1901998,GO:1903441" "molecular_function|protein binding|nucleoplasm|early endosome|Golgi apparatus|cytosol|intracellular protein transport|protein localization|endosome membrane|membrane|small GTPase binding|early endosome membrane|protein-containing complex|protein localization to cell surface|retrograde transport, endosome to Golgi|Golgi to plasma membrane protein transport|intracellular membrane-bounded organelle|cellular protein metabolic process|positive regulation of protein catabolic process|toxin transport|protein localization to ciliary membrane" hsa04142 Lysosome GGA2 1797.196479 1900.836164 1693.556794 0.890953585 -0.16657782 0.482978686 1 15.90781441 13.93595623 23062 "golgi associated, gamma adaptin ear containing, ARF binding protein 2" "GO:0005515,GO:0005794,GO:0005802,GO:0006886,GO:0010008,GO:0030136,GO:0031267,GO:0031901,GO:0034394,GO:0043001,GO:0044267" protein binding|Golgi apparatus|trans-Golgi network|intracellular protein transport|endosome membrane|clathrin-coated vesicle|small GTPase binding|early endosome membrane|protein localization to cell surface|Golgi to plasma membrane protein transport|cellular protein metabolic process hsa04142 Lysosome GGA3 1060.326284 1165.263549 955.3890203 0.819890935 -0.286496085 0.241519065 1 14.10477975 11.3708668 23163 "golgi associated, gamma adaptin ear containing, ARF binding protein 3" "GO:0005515,GO:0005764,GO:0005794,GO:0005802,GO:0006622,GO:0006886,GO:0010008,GO:0031267,GO:0031647,GO:0031648,GO:0031901,GO:0032456,GO:0032991,GO:0034394,GO:0043001,GO:0043130,GO:0044267,GO:0044877,GO:0045732,GO:0055038,GO:1902430" protein binding|lysosome|Golgi apparatus|trans-Golgi network|protein targeting to lysosome|intracellular protein transport|endosome membrane|small GTPase binding|regulation of protein stability|protein destabilization|early endosome membrane|endocytic recycling|protein-containing complex|protein localization to cell surface|Golgi to plasma membrane protein transport|ubiquitin binding|cellular protein metabolic process|protein-containing complex binding|positive regulation of protein catabolic process|recycling endosome membrane|negative regulation of amyloid-beta formation hsa04142 Lysosome GGACT 105.0377571 120.6880104 89.38750391 0.740649412 -0.433137294 0.349838593 1 1.04815253 0.763322999 87769 gamma-glutamylamine cyclotransferase "GO:0005515,GO:0005829,GO:0042219,GO:0061929,GO:0070062" protein binding|cytosol|cellular modified amino acid catabolic process|gamma-glutamylaminecyclotransferase activity|extracellular exosome GGCT 574.0297163 548.2981162 599.7613165 1.093859889 0.129427957 0.629512295 1 22.26914972 23.95170925 79017 gamma-glutamylcyclotransferase "GO:0001836,GO:0003839,GO:0005829,GO:0006750,GO:0042803,GO:0070062" release of cytochrome c from mitochondria|gamma-glutamylcyclotransferase activity|cytosol|glutathione biosynthetic process|protein homodimerization activity|extracellular exosome hsa00480 Glutathione metabolism GGCX 896.6737196 906.2004918 887.1469474 0.978974251 -0.030657181 0.906342954 1 6.152175896 5.922038022 2677 gamma-glutamyl carboxylase "GO:0005789,GO:0006464,GO:0007596,GO:0008488,GO:0016020,GO:0016021,GO:0017187,GO:0019842" endoplasmic reticulum membrane|cellular protein modification process|blood coagulation|gamma-glutamyl carboxylase activity|membrane|integral component of membrane|peptidyl-glutamic acid carboxylation|vitamin binding hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis GGH 2956.024199 2611.438845 3300.609553 1.263904594 0.337887565 0.153530769 1 60.62100546 75.33704928 8836 gamma-glutamyl hydrolase "GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005773,GO:0005829,GO:0006508,GO:0008238,GO:0008242,GO:0010043,GO:0032868,GO:0034722,GO:0035578,GO:0035580,GO:0042470,GO:0042493,GO:0043312,GO:0045471,GO:0046900,GO:0070062,GO:1904724" protein binding|extracellular region|extracellular space|nucleus|vacuole|cytosol|proteolysis|exopeptidase activity|omega peptidase activity|response to zinc ion|response to insulin|gamma-glutamyl-peptidase activity|azurophil granule lumen|specific granule lumen|melanosome|response to drug|neutrophil degranulation|response to ethanol|tetrahydrofolylpolyglutamate metabolic process|extracellular exosome|tertiary granule lumen "hsa00790,hsa01523" Folate biosynthesis|Antifolate resistance GGN 13.21337919 6.242483296 20.18427508 3.233372701 1.693039812 0.10474962 1 0.11644525 0.370210493 199720 gametogenetin "GO:0005515,GO:0006302,GO:0007275,GO:0007276,GO:0007283,GO:0030154,GO:0031625" protein binding|double-strand break repair|multicellular organism development|gamete generation|spermatogenesis|cell differentiation|ubiquitin protein ligase binding GGNBP2 1692.377603 1634.49021 1750.264996 1.070832352 0.098732632 0.679165121 1 30.91060894 32.54619506 79893 gametogenetin binding protein 2 "GO:0005634,GO:0005737,GO:0007283,GO:0008285,GO:0010629,GO:0030154,GO:0031410,GO:0033140,GO:0042532,GO:0060716,GO:0061099" nucleus|cytoplasm|spermatogenesis|negative regulation of cell population proliferation|negative regulation of gene expression|cell differentiation|cytoplasmic vesicle|negative regulation of peptidyl-serine phosphorylation of STAT protein|negative regulation of tyrosine phosphorylation of STAT protein|labyrinthine layer blood vessel development|negative regulation of protein tyrosine kinase activity GGPS1 665.0470382 578.4701187 751.6239576 1.299330654 0.377768615 0.143614213 1 6.524067425 8.335071003 9453 geranylgeranyl diphosphate synthase 1 "GO:0004161,GO:0004311,GO:0004337,GO:0004659,GO:0005515,GO:0005829,GO:0006695,GO:0006720,GO:0008299,GO:0033384,GO:0033386,GO:0042802,GO:0045337,GO:0045540,GO:0046872" dimethylallyltranstransferase activity|farnesyltranstransferase activity|geranyltranstransferase activity|prenyltransferase activity|protein binding|cytosol|cholesterol biosynthetic process|isoprenoid metabolic process|isoprenoid biosynthetic process|geranyl diphosphate biosynthetic process|geranylgeranyl diphosphate biosynthetic process|identical protein binding|farnesyl diphosphate biosynthetic process|regulation of cholesterol biosynthetic process|metal ion binding hsa00900 Terpenoid backbone biosynthesis GGT1 64.98182267 40.57614142 89.38750391 2.202957225 1.139441482 0.037816482 0.980643794 0.794669392 1.721328378 2678 gamma-glutamyltransferase 1 "GO:0000048,GO:0002682,GO:0002951,GO:0005515,GO:0005615,GO:0005886,GO:0006412,GO:0006508,GO:0006520,GO:0006536,GO:0006631,GO:0006691,GO:0006750,GO:0006751,GO:0006805,GO:0007283,GO:0016021,GO:0018215,GO:0019344,GO:0031179,GO:0031638,GO:0032355,GO:0032496,GO:0034612,GO:0036374,GO:0050727,GO:0070062,GO:0102953,GO:0103068,GO:1901750" peptidyltransferase activity|regulation of immune system process|leukotriene-C(4) hydrolase|protein binding|extracellular space|plasma membrane|translation|proteolysis|cellular amino acid metabolic process|glutamate metabolic process|fatty acid metabolic process|leukotriene metabolic process|glutathione biosynthetic process|glutathione catabolic process|xenobiotic metabolic process|spermatogenesis|integral component of membrane|protein phosphopantetheinylation|cysteine biosynthetic process|peptide modification|zymogen activation|response to estradiol|response to lipopolysaccharide|response to tumor necrosis factor|glutathione hydrolase activity|regulation of inflammatory response|extracellular exosome|hypoglycin A gamma-glutamyl transpeptidase activity|leukotriene C4 gamma-glutamyl transferase activity|leukotriene D4 biosynthetic process "hsa00430,hsa00480,hsa00590" Taurine and hypotaurine metabolism|Glutathione metabolism|Arachidonic acid metabolism GGT7 633.1401933 649.2182628 617.0621237 0.950469448 -0.073287842 0.783405412 1 10.64769068 9.950955088 2686 gamma-glutamyltransferase 7 "GO:0000048,GO:0005515,GO:0005886,GO:0006412,GO:0006508,GO:0006750,GO:0006751,GO:0007283,GO:0016021,GO:0018215,GO:0032355,GO:0032496,GO:0034612,GO:0036374,GO:0102953,GO:0103068,GO:1901750,GO:1902883" peptidyltransferase activity|protein binding|plasma membrane|translation|proteolysis|glutathione biosynthetic process|glutathione catabolic process|spermatogenesis|integral component of membrane|protein phosphopantetheinylation|response to estradiol|response to lipopolysaccharide|response to tumor necrosis factor|glutathione hydrolase activity|hypoglycin A gamma-glutamyl transpeptidase activity|leukotriene C4 gamma-glutamyl transferase activity|leukotriene D4 biosynthetic process|negative regulation of response to oxidative stress "hsa00430,hsa00480" Taurine and hypotaurine metabolism|Glutathione metabolism GHDC 404.5498508 439.0546585 370.0450431 0.842822268 -0.246699663 0.394125259 1 9.383876722 7.776594857 84514 GH3 domain containing "GO:0003674,GO:0005576,GO:0005635,GO:0005737,GO:0005783,GO:0008150,GO:0016020,GO:0016881,GO:0034774,GO:0035580,GO:0043312" molecular_function|extracellular region|nuclear envelope|cytoplasm|endoplasmic reticulum|biological_process|membrane|acid-amino acid ligase activity|secretory granule lumen|specific granule lumen|neutrophil degranulation GHITM 5755.37249 5639.043244 5871.701735 1.041258505 0.058328279 0.809791457 1 126.3414668 129.3527466 27069 growth hormone inducible transmembrane protein "GO:0003674,GO:0005515,GO:0005739,GO:0006915,GO:0007007,GO:0031305,GO:0070062,GO:0090201,GO:1905448" molecular_function|protein binding|mitochondrion|apoptotic process|inner mitochondrial membrane organization|integral component of mitochondrial inner membrane|extracellular exosome|negative regulation of release of cytochrome c from mitochondria|positive regulation of mitochondrial ATP synthesis coupled electron transport GHR 6.965865472 6.242483296 7.689247648 1.231761029 0.300722389 0.937576592 1 0.053278404 0.064528095 2690 growth hormone receptor "GO:0000187,GO:0004896,GO:0004903,GO:0005515,GO:0005576,GO:0005615,GO:0005829,GO:0005886,GO:0005887,GO:0006897,GO:0007259,GO:0009897,GO:0009986,GO:0016021,GO:0017046,GO:0019221,GO:0019530,GO:0019838,GO:0019901,GO:0019955,GO:0032870,GO:0036464,GO:0040014,GO:0040018,GO:0042445,GO:0042531,GO:0042802,GO:0042803,GO:0042976,GO:0043235,GO:0046427,GO:0048009,GO:0050731,GO:0060396,GO:0060397,GO:0070064,GO:0070195" activation of MAPK activity|cytokine receptor activity|growth hormone receptor activity|protein binding|extracellular region|extracellular space|cytosol|plasma membrane|integral component of plasma membrane|endocytosis|receptor signaling pathway via JAK-STAT|external side of plasma membrane|cell surface|integral component of membrane|peptide hormone binding|cytokine-mediated signaling pathway|taurine metabolic process|growth factor binding|protein kinase binding|cytokine binding|cellular response to hormone stimulus|cytoplasmic ribonucleoprotein granule|regulation of multicellular organism growth|positive regulation of multicellular organism growth|hormone metabolic process|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|protein homodimerization activity|activation of Janus kinase activity|receptor complex|positive regulation of receptor signaling pathway via JAK-STAT|insulin-like growth factor receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|growth hormone receptor signaling pathway|growth hormone receptor signaling pathway via JAK-STAT|proline-rich region binding|growth hormone receptor complex "hsa04060,hsa04080,hsa04151,hsa04630,hsa04935" "Cytokine-cytokine receptor interaction|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|JAK-STAT signaling pathway|Growth hormone synthesis, secretion and action" GID4 482.2298761 472.3479027 492.1118495 1.041841928 0.059136403 0.837090769 1 4.951549682 5.07240767 79018 GID complex subunit 4 homolog "GO:0000151,GO:0016567,GO:0043161,GO:0061630" ubiquitin ligase complex|protein ubiquitination|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity GID8 1121.379809 1115.323682 1127.435936 1.010859856 0.015582998 0.952943616 1 13.62388992 13.54139024 54994 GID complex subunit 8 homolog "GO:0000151,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008284,GO:0016055,GO:0030054,GO:0042803,GO:0043161,GO:0090263" ubiquitin ligase complex|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|positive regulation of cell population proliferation|Wnt signaling pathway|cell junction|protein homodimerization activity|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of canonical Wnt signaling pathway GIGYF1 1199.138478 1251.617901 1146.659056 0.916141464 -0.126357709 0.603509705 1 9.788474061 8.81756586 64599 GRB10 interacting GYF protein 1 "GO:0005515,GO:0008150,GO:0032991" protein binding|biological_process|protein-containing complex GIGYF2 1698.535183 1758.299462 1638.770905 0.932020364 -0.101566617 0.670338481 1 11.73845517 10.75740516 26058 GRB10 interacting GYF protein 2 "GO:0003723,GO:0005515,GO:0005768,GO:0005783,GO:0005794,GO:0005829,GO:0010494,GO:0016020,GO:0016441,GO:0017148,GO:0032991,GO:0043204,GO:0045296,GO:0048009,GO:0061157,GO:0070064,GO:1990635" RNA binding|protein binding|endosome|endoplasmic reticulum|Golgi apparatus|cytosol|cytoplasmic stress granule|membrane|posttranscriptional gene silencing|negative regulation of translation|protein-containing complex|perikaryon|cadherin binding|insulin-like growth factor receptor signaling pathway|mRNA destabilization|proline-rich region binding|proximal dendrite GIMAP2 42.1518535 46.81862472 37.48508228 0.800644669 -0.320765987 0.637014227 1 1.73154813 1.36315601 26157 "GTPase, IMAP family member 2" "GO:0005515,GO:0005525,GO:0005783,GO:0005811,GO:0042802" protein binding|GTP binding|endoplasmic reticulum|lipid droplet|identical protein binding GIN1 104.9289311 92.59683556 117.2610266 1.266361058 0.340688797 0.466392463 1 0.976818132 1.216304848 54826 gypsy retrotransposon integrase 1 "GO:0003676,GO:0015074" nucleic acid binding|DNA integration GINM1 1015.846383 1032.090572 999.6021942 0.968521777 -0.046143607 0.854631555 1 28.34831544 26.99652252 116254 glycoprotein integral membrane 1 "GO:0005515,GO:0016021" protein binding|integral component of membrane GINS1 1288.298884 1119.485338 1457.112429 1.301591348 0.380276566 0.114369239 1 17.13851834 21.93406394 9837 GINS complex subunit 1 "GO:0000811,GO:0001833,GO:0005634,GO:0005654,GO:0005737,GO:0006271,GO:0071162,GO:1902983" GINS complex|inner cell mass cell proliferation|nucleus|nucleoplasm|cytoplasm|DNA strand elongation involved in DNA replication|CMG complex|DNA strand elongation involved in mitotic DNA replication GINS2 413.8148105 404.7210003 422.9086206 1.044938662 0.063418259 0.832609331 1 8.218879735 8.444512876 51659 GINS complex subunit 2 "GO:0000727,GO:0000811,GO:0005515,GO:0005654,GO:0006271,GO:0071162" double-strand break repair via break-induced replication|GINS complex|protein binding|nucleoplasm|DNA strand elongation involved in DNA replication|CMG complex GINS3 360.094487 344.3769952 375.8119788 1.09128073 0.126022281 0.678602091 1 7.932139531 8.511341387 64785 GINS complex subunit 3 "GO:0000811,GO:0005515,GO:0005654,GO:0006271,GO:0071162,GO:1902975" GINS complex|protein binding|nucleoplasm|DNA strand elongation involved in DNA replication|CMG complex|mitotic DNA replication initiation GINS4 623.2260789 704.3601985 542.0919592 0.769623213 -0.377775781 0.147846439 1 9.824989346 7.43500774 84296 GINS complex subunit 4 "GO:0000727,GO:0000811,GO:0001833,GO:0005515,GO:0005654,GO:0005737,GO:0006271,GO:0071162" double-strand break repair via break-induced replication|GINS complex|inner cell mass cell proliferation|protein binding|nucleoplasm|cytoplasm|DNA strand elongation involved in DNA replication|CMG complex GIPC1 1927.33496 1746.854909 2107.815011 1.206634278 0.270988472 0.252502739 1 48.50490942 57.54830478 10755 GIPC PDZ domain containing family member 1 "GO:0003779,GO:0005102,GO:0005515,GO:0005737,GO:0005829,GO:0005903,GO:0005938,GO:0006605,GO:0007186,GO:0007268,GO:0008021,GO:0012506,GO:0014047,GO:0016020,GO:0017022,GO:0030139,GO:0030165,GO:0030511,GO:0031410,GO:0031647,GO:0032435,GO:0032467,GO:0042802,GO:0043197,GO:0043198,GO:0043542,GO:0045296,GO:0048023,GO:0048167,GO:0070062,GO:0098685,GO:0098761,GO:0098978,GO:2000300" actin binding|signaling receptor binding|protein binding|cytoplasm|cytosol|brush border|cell cortex|protein targeting|G protein-coupled receptor signaling pathway|chemical synaptic transmission|synaptic vesicle|vesicle membrane|glutamate secretion|membrane|myosin binding|endocytic vesicle|PDZ domain binding|positive regulation of transforming growth factor beta receptor signaling pathway|cytoplasmic vesicle|regulation of protein stability|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of cytokinesis|identical protein binding|dendritic spine|dendritic shaft|endothelial cell migration|cadherin binding|positive regulation of melanin biosynthetic process|regulation of synaptic plasticity|extracellular exosome|Schaffer collateral - CA1 synapse|cellular response to interleukin-7|glutamatergic synapse|regulation of synaptic vesicle exocytosis GIPC3 70.29271813 79.07145508 61.51398118 0.777954334 -0.362242623 0.504544917 1 0.95408054 0.729810859 126326 GIPC PDZ domain containing family member 3 GO:0005515 protein binding GIPR 82.0693938 72.82897178 91.30981582 1.253756762 0.326257481 0.526137027 1 1.011383911 1.246810662 2696 gastric inhibitory polypeptide receptor "GO:0002029,GO:0004888,GO:0005515,GO:0005886,GO:0006091,GO:0007166,GO:0007186,GO:0007188,GO:0007190,GO:0007204,GO:0007584,GO:0008528,GO:0009749,GO:0016021,GO:0016519,GO:0017046,GO:0031018,GO:0032024,GO:0038192,GO:0043950,GO:0048678,GO:0050796,GO:0051592,GO:0070542" desensitization of G protein-coupled receptor signaling pathway|transmembrane signaling receptor activity|protein binding|plasma membrane|generation of precursor metabolites and energy|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|positive regulation of cytosolic calcium ion concentration|response to nutrient|G protein-coupled peptide receptor activity|response to glucose|integral component of membrane|gastric inhibitory peptide receptor activity|peptide hormone binding|endocrine pancreas development|positive regulation of insulin secretion|gastric inhibitory peptide signaling pathway|positive regulation of cAMP-mediated signaling|response to axon injury|regulation of insulin secretion|response to calcium ion|response to fatty acid "hsa04024,hsa04080" cAMP signaling pathway|Neuroactive ligand-receptor interaction GIT1 1553.372909 1429.528675 1677.217143 1.173265827 0.230529922 0.333622739 1 21.33426119 24.61190374 28964 GIT ArfGAP 1 "GO:0001957,GO:0005096,GO:0005515,GO:0005739,GO:0005829,GO:0005925,GO:0007420,GO:0007626,GO:0008277,GO:0016020,GO:0032465,GO:0032691,GO:0043547,GO:0044305,GO:0044877,GO:0045454,GO:0045820,GO:0046872,GO:0048013,GO:0048666,GO:0061743,GO:0071222,GO:0099171,GO:0106015,GO:2000300" intramembranous ossification|GTPase activator activity|protein binding|mitochondrion|cytosol|focal adhesion|brain development|locomotory behavior|regulation of G protein-coupled receptor signaling pathway|membrane|regulation of cytokinesis|negative regulation of interleukin-1 beta production|positive regulation of GTPase activity|calyx of Held|protein-containing complex binding|cell redox homeostasis|negative regulation of glycolytic process|metal ion binding|ephrin receptor signaling pathway|neuron development|motor learning|cellular response to lipopolysaccharide|presynaptic modulation of chemical synaptic transmission|negative regulation of inflammatory response to wounding|regulation of synaptic vesicle exocytosis "hsa04144,hsa04810,hsa05120" Endocytosis|Regulation of actin cytoskeleton|Epithelial cell signaling in Helicobacter pylori infection GIT2 1912.257791 1893.553266 1930.962316 1.019756006 0.028224004 0.90734226 1 14.67123369 14.71072527 9815 GIT ArfGAP 2 "GO:0005096,GO:0005515,GO:0005654,GO:0005925,GO:0008277,GO:0043547,GO:0046872" GTPase activator activity|protein binding|nucleoplasm|focal adhesion|regulation of G protein-coupled receptor signaling pathway|positive regulation of GTPase activity|metal ion binding "hsa04144,hsa05135" Endocytosis|Yersinia infection GJA1 879.3427299 981.1102913 777.5751684 0.792546134 -0.335433178 0.177777456 1 16.98347488 13.23494935 2697 gap junction protein alpha 1 "GO:0000132,GO:0000139,GO:0001937,GO:0002544,GO:0002931,GO:0003104,GO:0003158,GO:0005243,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005764,GO:0005769,GO:0005771,GO:0005789,GO:0005794,GO:0005886,GO:0005887,GO:0005916,GO:0005921,GO:0005922,GO:0005925,GO:0006915,GO:0007165,GO:0007204,GO:0007267,GO:0007283,GO:0007507,GO:0008013,GO:0009268,GO:0009749,GO:0010232,GO:0010628,GO:0010644,GO:0010649,GO:0010652,GO:0014047,GO:0014704,GO:0015075,GO:0015562,GO:0015631,GO:0015867,GO:0016264,GO:0016324,GO:0017124,GO:0022898,GO:0030054,GO:0030165,GO:0030308,GO:0030660,GO:0032024,GO:0032277,GO:0032355,GO:0032496,GO:0032526,GO:0034220,GO:0034405,GO:0034613,GO:0034634,GO:0034775,GO:0035437,GO:0035633,GO:0042908,GO:0042981,GO:0043123,GO:0043231,GO:0043434,GO:0044291,GO:0045121,GO:0045732,GO:0045907,GO:0046697,GO:0046849,GO:0048812,GO:0051924,GO:0055077,GO:0060044,GO:0060348,GO:0061045,GO:0070160,GO:0071253,GO:0071260,GO:0071374,GO:0086014,GO:0086064,GO:0086075,GO:0097718,GO:0120162,GO:0140115,GO:1901164,GO:1903763,GO:1904646,GO:1904707,GO:1905332,GO:1905772,GO:1905867,GO:2000279,GO:2000648,GO:2000810,GO:2000987" establishment of mitotic spindle orientation|Golgi membrane|negative regulation of endothelial cell proliferation|chronic inflammatory response|response to ischemia|positive regulation of glomerular filtration|endothelium development|gap junction channel activity|protein binding|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|lysosome|early endosome|multivesicular body|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|fascia adherens|gap junction|connexin complex|focal adhesion|apoptotic process|signal transduction|positive regulation of cytosolic calcium ion concentration|cell-cell signaling|spermatogenesis|heart development|beta-catenin binding|response to pH|response to glucose|vascular transport|positive regulation of gene expression|cell communication by electrical coupling|regulation of cell communication by electrical coupling|positive regulation of cell communication by chemical coupling|glutamate secretion|intercalated disc|ion transmembrane transporter activity|efflux transmembrane transporter activity|tubulin binding|ATP transport|gap junction assembly|apical plasma membrane|SH3 domain binding|regulation of transmembrane transporter activity|cell junction|PDZ domain binding|negative regulation of cell growth|Golgi-associated vesicle membrane|positive regulation of insulin secretion|negative regulation of gonadotropin secretion|response to estradiol|response to lipopolysaccharide|response to retinoic acid|ion transmembrane transport|response to fluid shear stress|cellular protein localization|glutathione transmembrane transporter activity|glutathione transmembrane transport|maintenance of protein localization in endoplasmic reticulum|maintenance of blood-brain barrier|xenobiotic transport|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|response to peptide hormone|cell-cell contact zone|membrane raft|positive regulation of protein catabolic process|positive regulation of vasoconstriction|decidualization|bone remodeling|neuron projection morphogenesis|regulation of calcium ion transport|gap junction hemi-channel activity|negative regulation of cardiac muscle cell proliferation|bone development|negative regulation of wound healing|tight junction|connexin binding|cellular response to mechanical stimulus|cellular response to parathyroid hormone stimulus|atrial cardiac muscle cell action potential|cell communication by electrical coupling involved in cardiac conduction|gap junction channel activity involved in cardiac conduction electrical coupling|disordered domain specific binding|positive regulation of cold-induced thermogenesis|export across plasma membrane|negative regulation of trophoblast cell migration|gap junction channel activity involved in cell communication by electrical coupling|cellular response to amyloid-beta|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of morphogenesis of an epithelium|positive regulation of mesodermal cell differentiation|epididymis development|negative regulation of DNA biosynthetic process|positive regulation of stem cell proliferation|regulation of bicellular tight junction assembly|positive regulation of behavioral fear response "hsa04540,hsa05412" Gap junction|Arrhythmogenic right ventricular cardiomyopathy GJA3 88.95097093 89.47559391 88.42634795 0.988273384 -0.017017909 0.998621887 1 0.904555408 0.878989024 2700 gap junction protein alpha 3 "GO:0005243,GO:0005887,GO:0005922,GO:0007267,GO:0007601,GO:0055077,GO:0055085,GO:1990349" gap junction channel activity|integral component of plasma membrane|connexin complex|cell-cell signaling|visual perception|gap junction hemi-channel activity|transmembrane transport|gap junction-mediated intercellular transport GJA9 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.024342383 0.06633508 81025 gap junction protein alpha 9 "GO:0005243,GO:0005922,GO:0007267,GO:0016021,GO:0055085" gap junction channel activity|connexin complex|cell-cell signaling|integral component of membrane|transmembrane transport GJB2 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.067330206 0.061160193 2706 gap junction protein beta 2 "GO:0002931,GO:0005243,GO:0005509,GO:0005515,GO:0005793,GO:0005829,GO:0005886,GO:0005887,GO:0005921,GO:0005922,GO:0007267,GO:0007568,GO:0007605,GO:0010644,GO:0016264,GO:0016328,GO:0032355,GO:0032496,GO:0032526,GO:0032570,GO:0034599,GO:0042802,GO:0044297,GO:0044752,GO:0046677,GO:0046697,GO:0048471,GO:0048839,GO:0055085,GO:0071377,GO:0071549,GO:0097449,GO:1903763,GO:1905867,GO:1990349" response to ischemia|gap junction channel activity|calcium ion binding|protein binding|endoplasmic reticulum-Golgi intermediate compartment|cytosol|plasma membrane|integral component of plasma membrane|gap junction|connexin complex|cell-cell signaling|aging|sensory perception of sound|cell communication by electrical coupling|gap junction assembly|lateral plasma membrane|response to estradiol|response to lipopolysaccharide|response to retinoic acid|response to progesterone|cellular response to oxidative stress|identical protein binding|cell body|response to human chorionic gonadotropin|response to antibiotic|decidualization|perinuclear region of cytoplasm|inner ear development|transmembrane transport|cellular response to glucagon stimulus|cellular response to dexamethasone stimulus|astrocyte projection|gap junction channel activity involved in cell communication by electrical coupling|epididymis development|gap junction-mediated intercellular transport GJB3 24.4648175 11.44455271 37.48508228 3.275364554 1.71165549 0.033740029 0.933997777 0.258037492 0.831024133 2707 gap junction protein beta 3 "GO:0001701,GO:0001890,GO:0005243,GO:0005515,GO:0005737,GO:0005921,GO:0005922,GO:0007267,GO:0007283,GO:0016021,GO:0030054,GO:0043231,GO:0043588,GO:0055085,GO:0071300" in utero embryonic development|placenta development|gap junction channel activity|protein binding|cytoplasm|gap junction|connexin complex|cell-cell signaling|spermatogenesis|integral component of membrane|cell junction|intracellular membrane-bounded organelle|skin development|transmembrane transport|cellular response to retinoic acid GJC1 3906.307573 3852.652607 3959.962539 1.027853519 0.039634678 0.868701267 1 25.46872151 25.74005972 10052 gap junction protein gamma 1 "GO:0001570,GO:0005216,GO:0005243,GO:0005515,GO:0005789,GO:0005886,GO:0005921,GO:0005922,GO:0006936,GO:0007043,GO:0007267,GO:0007268,GO:0007601,GO:0014704,GO:0016021,GO:0016264,GO:0034220,GO:0045202,GO:0048468,GO:0048738,GO:0086014,GO:0086020,GO:0086021,GO:0086053,GO:0086077" vasculogenesis|ion channel activity|gap junction channel activity|protein binding|endoplasmic reticulum membrane|plasma membrane|gap junction|connexin complex|muscle contraction|cell-cell junction assembly|cell-cell signaling|chemical synaptic transmission|visual perception|intercalated disc|integral component of membrane|gap junction assembly|ion transmembrane transport|synapse|cell development|cardiac muscle tissue development|atrial cardiac muscle cell action potential|gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling|SA node cell to atrial cardiac muscle cell communication by electrical coupling|AV node cell to bundle of His cell communication by electrical coupling|gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling GJC2 6.846978582 3.121241648 10.57271552 3.38734283 1.760154008 0.229675583 1 0.076939922 0.256260737 57165 gap junction protein gamma 2 "GO:0001932,GO:0005243,GO:0005921,GO:0005922,GO:0007267,GO:0007420,GO:0009636,GO:0010628,GO:0010644,GO:0016021,GO:0033270,GO:0043204,GO:0043209,GO:0055085,GO:0070447,GO:1903763,GO:1904427,GO:1990769,GO:2000134" regulation of protein phosphorylation|gap junction channel activity|gap junction|connexin complex|cell-cell signaling|brain development|response to toxic substance|positive regulation of gene expression|cell communication by electrical coupling|integral component of membrane|paranode region of axon|perikaryon|myelin sheath|transmembrane transport|positive regulation of oligodendrocyte progenitor proliferation|gap junction channel activity involved in cell communication by electrical coupling|positive regulation of calcium ion transmembrane transport|proximal neuron projection|negative regulation of G1/S transition of mitotic cell cycle GK 590.8348543 585.7530159 595.9166927 1.017351472 0.024818183 0.931848711 1 7.701542718 7.704064761 2710 glycerol kinase "GO:0004370,GO:0005515,GO:0005524,GO:0005739,GO:0005741,GO:0005829,GO:0006071,GO:0006641,GO:0016310,GO:0016773,GO:0019432,GO:0019563,GO:0046167,GO:0070062" "glycerol kinase activity|protein binding|ATP binding|mitochondrion|mitochondrial outer membrane|cytosol|glycerol metabolic process|triglyceride metabolic process|phosphorylation|phosphotransferase activity, alcohol group as acceptor|triglyceride biosynthetic process|glycerol catabolic process|glycerol-3-phosphate biosynthetic process|extracellular exosome" "hsa00561,hsa03320" Glycerolipid metabolism|PPAR signaling pathway GK5 538.9274023 598.2379825 479.616822 0.801715765 -0.31883725 0.235741663 1 3.041232769 2.397404211 256356 glycerol kinase 5 "GO:0004370,GO:0005524,GO:0005739,GO:0006071,GO:0006641,GO:0016310,GO:0016773,GO:0019563,GO:0046167" "glycerol kinase activity|ATP binding|mitochondrion|glycerol metabolic process|triglyceride metabolic process|phosphorylation|phosphotransferase activity, alcohol group as acceptor|glycerol catabolic process|glycerol-3-phosphate biosynthetic process" GKAP1 110.8839508 122.7688382 98.99906347 0.806385928 -0.310457632 0.499047541 1 2.895248455 2.295619776 80318 G kinase anchoring protein 1 "GO:0005515,GO:0005794,GO:0007165,GO:0042802,GO:0046628" protein binding|Golgi apparatus|signal transduction|identical protein binding|positive regulation of insulin receptor signaling pathway GLA 1196.240533 1188.152654 1204.328413 1.013614209 0.019508654 0.939479064 1 48.1104123 47.94937463 2717 galactosidase alpha "GO:0003824,GO:0004557,GO:0005102,GO:0005515,GO:0005576,GO:0005737,GO:0005764,GO:0005794,GO:0006687,GO:0009311,GO:0016139,GO:0016787,GO:0017041,GO:0035578,GO:0042803,GO:0043202,GO:0043312,GO:0045019,GO:0046477,GO:0046479,GO:0051001,GO:0052692,GO:0070062" catalytic activity|alpha-galactosidase activity|signaling receptor binding|protein binding|extracellular region|cytoplasm|lysosome|Golgi apparatus|glycosphingolipid metabolic process|oligosaccharide metabolic process|glycoside catabolic process|hydrolase activity|galactosylgalactosylglucosylceramidase activity|azurophil granule lumen|protein homodimerization activity|lysosomal lumen|neutrophil degranulation|negative regulation of nitric oxide biosynthetic process|glycosylceramide catabolic process|glycosphingolipid catabolic process|negative regulation of nitric-oxide synthase activity|raffinose alpha-galactosidase activity|extracellular exosome "hsa00052,hsa00561,hsa00600,hsa00603,hsa04142" Galactose metabolism|Glycerolipid metabolism|Sphingolipid metabolism|Glycosphingolipid biosynthesis - globo and isoglobo series|Lysosome GLB1 1205.669039 1145.495685 1265.842394 1.105060814 0.144125767 0.553031049 1 18.60974105 20.22076992 2720 galactosidase beta 1 "GO:0004565,GO:0005515,GO:0005576,GO:0005737,GO:0005773,GO:0005794,GO:0006027,GO:0006687,GO:0016936,GO:0019388,GO:0035578,GO:0042340,GO:0042803,GO:0043202,GO:0043231,GO:0043312,GO:0044262,GO:0048471,GO:0051413,GO:0070062,GO:1904016,GO:1904813" beta-galactosidase activity|protein binding|extracellular region|cytoplasm|vacuole|Golgi apparatus|glycosaminoglycan catabolic process|glycosphingolipid metabolic process|galactoside binding|galactose catabolic process|azurophil granule lumen|keratan sulfate catabolic process|protein homodimerization activity|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|cellular carbohydrate metabolic process|perinuclear region of cytoplasm|response to cortisone|extracellular exosome|response to Thyroglobulin triiodothyronine|ficolin-1-rich granule lumen "hsa00052,hsa00511,hsa00531,hsa00600,hsa00604,hsa04142" Galactose metabolism|Other glycan degradation|Glycosaminoglycan degradation|Sphingolipid metabolism|Glycosphingolipid biosynthesis - ganglio series|Lysosome GLB1L 163.6481488 170.6278768 156.6684208 0.918187718 -0.12313896 0.766275499 1 3.418204272 3.086033744 79411 galactosidase beta 1 like "GO:0004565,GO:0005576,GO:0005773,GO:0005975" beta-galactosidase activity|extracellular region|vacuole|carbohydrate metabolic process GLCCI1 177.9912606 156.0620824 199.9204388 1.28103147 0.357305918 0.350221021 1 1.756748894 2.212792375 113263 glucocorticoid induced 1 GO:0005737 cytoplasm GLCE 1072.351409 1039.373469 1105.329349 1.063457345 0.088762168 0.719127389 1 6.8052327 7.115972054 26035 glucuronic acid epimerase "GO:0000139,GO:0005509,GO:0005794,GO:0015012,GO:0016021,GO:0016857,GO:0030210,GO:0042803,GO:0047464" "Golgi membrane|calcium ion binding|Golgi apparatus|heparan sulfate proteoglycan biosynthetic process|integral component of membrane|racemase and epimerase activity, acting on carbohydrates and derivatives|heparin biosynthetic process|protein homodimerization activity|heparosan-N-sulfate-glucuronate 5-epimerase activity" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin GLDC 11.96979007 11.44455271 12.49502743 1.091788185 0.12669299 0.995605371 1 0.158931757 0.170616196 2731 glycine decarboxylase "GO:0004375,GO:0005654,GO:0005739,GO:0005759,GO:0005886,GO:0005960,GO:0006546,GO:0009055,GO:0016594,GO:0016829,GO:0019464,GO:0019899,GO:0022900,GO:0030170,GO:0036255,GO:0042803,GO:0065003,GO:0070280,GO:1903442" glycine dehydrogenase (decarboxylating) activity|nucleoplasm|mitochondrion|mitochondrial matrix|plasma membrane|glycine cleavage complex|glycine catabolic process|electron transfer activity|glycine binding|lyase activity|glycine decarboxylation via glycine cleavage system|enzyme binding|electron transport chain|pyridoxal phosphate binding|response to methylamine|protein homodimerization activity|protein-containing complex assembly|pyridoxal binding|response to lipoic acid "hsa00260,hsa00630" "Glycine, serine and threonine metabolism|Glyoxylate and dicarboxylate metabolism" GLDN 24.49941604 24.96993318 24.0288989 0.962313304 -0.055421421 1 1 0.16451845 0.15566905 342035 gliomedin "GO:0005581,GO:0005615,GO:0005886,GO:0009986,GO:0016021,GO:0030424,GO:0032528,GO:0034113,GO:0045162,GO:0086080" collagen trimer|extracellular space|plasma membrane|cell surface|integral component of membrane|axon|microvillus organization|heterotypic cell-cell adhesion|clustering of voltage-gated sodium channels|protein binding involved in heterotypic cell-cell adhesion GLE1 1557.572965 1640.732693 1474.413236 0.898630985 -0.154199287 0.518395434 1 23.40002359 20.67611138 2733 GLE1 RNA export mediator "GO:0000822,GO:0005515,GO:0005543,GO:0005615,GO:0005635,GO:0005643,GO:0005730,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0006406,GO:0006446,GO:0006449,GO:0016020,GO:0016973,GO:0031369,GO:0031965,GO:0036064,GO:0042802,GO:0044614" inositol hexakisphosphate binding|protein binding|phospholipid binding|extracellular space|nuclear envelope|nuclear pore|nucleolus|cytoplasm|centrosome|centriole|cytosol|mRNA export from nucleus|regulation of translational initiation|regulation of translational termination|membrane|poly(A)+ mRNA export from nucleus|translation initiation factor binding|nuclear membrane|ciliary basal body|identical protein binding|nuclear pore cytoplasmic filaments "hsa03013,hsa03015,hsa05014" RNA transport|mRNA surveillance pathway|Amyotrophic lateral sclerosis GLG1 4196.291167 4362.45541 4030.126923 0.923820772 -0.11431511 0.632119514 1 25.0690457 22.77176553 2734 golgi glycoprotein 1 "GO:0000139,GO:0005102,GO:0005794,GO:0005856,GO:0005886,GO:0010955,GO:0016020,GO:0016021,GO:0017134,GO:0030512,GO:0031012,GO:0032330,GO:0050900,GO:0060349,GO:0070062,GO:0150051" Golgi membrane|signaling receptor binding|Golgi apparatus|cytoskeleton|plasma membrane|negative regulation of protein processing|membrane|integral component of membrane|fibroblast growth factor binding|negative regulation of transforming growth factor beta receptor signaling pathway|extracellular matrix|regulation of chondrocyte differentiation|leukocyte migration|bone morphogenesis|extracellular exosome|postsynaptic Golgi apparatus hsa04514 Cell adhesion molecules GLI1 48.64217141 40.57614142 56.7082014 1.397575014 0.482925721 0.435788742 1 0.533105389 0.732587289 2735 GLI family zinc finger 1 "GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001649,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005930,GO:0006357,GO:0007224,GO:0007283,GO:0007418,GO:0008017,GO:0008284,GO:0008589,GO:0009611,GO:0009913,GO:0009953,GO:0009954,GO:0021696,GO:0021938,GO:0021983,GO:0030324,GO:0030850,GO:0045667,GO:0045740,GO:0045880,GO:0045893,GO:0045944,GO:0046872,GO:0048546,GO:0060032,GO:0060045,GO:0060070,GO:0090090,GO:0097421,GO:0097542,GO:0097546,GO:1902808,GO:2000345" "transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|osteoblast differentiation|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|axoneme|regulation of transcription by RNA polymerase II|smoothened signaling pathway|spermatogenesis|ventral midline development|microtubule binding|positive regulation of cell population proliferation|regulation of smoothened signaling pathway|response to wounding|epidermal cell differentiation|dorsal/ventral pattern formation|proximal/distal pattern formation|cerebellar cortex morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|pituitary gland development|lung development|prostate gland development|regulation of osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|digestive tract morphogenesis|notochord regression|positive regulation of cardiac muscle cell proliferation|canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|liver regeneration|ciliary tip|ciliary base|positive regulation of cell cycle G1/S phase transition|regulation of hepatocyte proliferation" "hsa04024,hsa04340,hsa05200,hsa05217" cAMP signaling pathway|Hedgehog signaling pathway|Pathways in cancer|Basal cell carcinoma zf-C2H2 GLI2 89.66429227 108.2030438 71.12554074 0.657334011 -0.605301462 0.213934994 1 0.585243496 0.378263014 2736 GLI family zinc finger 2 "GO:0000122,GO:0000978,GO:0000981,GO:0001228,GO:0001501,GO:0001701,GO:0001822,GO:0002062,GO:0002076,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005929,GO:0005930,GO:0006357,GO:0007224,GO:0007389,GO:0007411,GO:0007418,GO:0007442,GO:0007507,GO:0008134,GO:0008270,GO:0009952,GO:0009954,GO:0016020,GO:0016607,GO:0021508,GO:0021513,GO:0021517,GO:0021696,GO:0021775,GO:0021776,GO:0021938,GO:0021965,GO:0021983,GO:0030324,GO:0030879,GO:0030902,GO:0031069,GO:0031514,GO:0032331,GO:0033089,GO:0035295,GO:0042475,GO:0042733,GO:0043066,GO:0043565,GO:0045666,GO:0045740,GO:0045879,GO:0045893,GO:0045944,GO:0048566,GO:0048589,GO:0048666,GO:0048754,GO:0060032,GO:0060513,GO:0060603,GO:0060831,GO:0071407,GO:0090103,GO:0097542,GO:0097546,GO:1901620,GO:1990837,GO:1990841" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|skeletal system development|in utero embryonic development|kidney development|chondrocyte differentiation|osteoblast development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|cilium|axoneme|regulation of transcription by RNA polymerase II|smoothened signaling pathway|pattern specification process|axon guidance|ventral midline development|hindgut morphogenesis|heart development|transcription factor binding|zinc ion binding|anterior/posterior pattern specification|proximal/distal pattern formation|membrane|nuclear speck|floor plate formation|spinal cord dorsal/ventral patterning|ventral spinal cord development|cerebellar cortex morphogenesis|smoothened signaling pathway involved in ventral spinal cord interneuron specification|smoothened signaling pathway involved in spinal cord motor neuron cell fate specification|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|spinal cord ventral commissure morphogenesis|pituitary gland development|lung development|mammary gland development|hindbrain development|hair follicle morphogenesis|motile cilium|negative regulation of chondrocyte differentiation|positive regulation of T cell differentiation in thymus|tube development|odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|negative regulation of apoptotic process|sequence-specific DNA binding|positive regulation of neuron differentiation|positive regulation of DNA replication|negative regulation of smoothened signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|embryonic digestive tract development|developmental growth|neuron development|branching morphogenesis of an epithelial tube|notochord regression|prostatic bud formation|mammary gland duct morphogenesis|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|cellular response to organic cyclic compound|cochlea morphogenesis|ciliary tip|ciliary base|regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding" "hsa04340,hsa04390,hsa05200,hsa05217" Hedgehog signaling pathway|Hippo signaling pathway|Pathways in cancer|Basal cell carcinoma zf-C2H2 GLI3 628.9433248 728.2897178 529.5969318 0.727178922 -0.459617713 0.077732943 1 2.753434663 1.96873488 2737 GLI family zinc finger 3 "GO:0000122,GO:0000977,GO:0000978,GO:0000981,GO:0001656,GO:0001658,GO:0001701,GO:0002052,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005929,GO:0005930,GO:0006357,GO:0007224,GO:0007411,GO:0007442,GO:0007507,GO:0008013,GO:0008285,GO:0009952,GO:0009954,GO:0016485,GO:0016607,GO:0017053,GO:0021631,GO:0021766,GO:0021775,GO:0021776,GO:0021798,GO:0021819,GO:0021861,GO:0022018,GO:0030318,GO:0030324,GO:0030850,GO:0032332,GO:0033077,GO:0035035,GO:0035108,GO:0036033,GO:0042060,GO:0042307,GO:0042475,GO:0042733,GO:0042826,GO:0043066,GO:0043231,GO:0043585,GO:0043586,GO:0043627,GO:0045060,GO:0045665,GO:0045669,GO:0045879,GO:0045892,GO:0045893,GO:0045944,GO:0046638,GO:0046639,GO:0046872,GO:0048557,GO:0048566,GO:0048589,GO:0048593,GO:0048702,GO:0048709,GO:0060021,GO:0060364,GO:0060366,GO:0060367,GO:0060594,GO:0060831,GO:0060840,GO:0060873,GO:0060875,GO:0061005,GO:0070242,GO:0071625,GO:0090090,GO:0097421,GO:0097542,GO:0097546,GO:0120223,GO:1901620,GO:1903010,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|metanephros development|branching involved in ureteric bud morphogenesis|in utero embryonic development|positive regulation of neuroblast proliferation|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|cilium|axoneme|regulation of transcription by RNA polymerase II|smoothened signaling pathway|axon guidance|hindgut morphogenesis|heart development|beta-catenin binding|negative regulation of cell population proliferation|anterior/posterior pattern specification|proximal/distal pattern formation|protein processing|nuclear speck|transcription repressor complex|optic nerve morphogenesis|hippocampus development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|smoothened signaling pathway involved in spinal cord motor neuron cell fate specification|forebrain dorsal/ventral pattern formation|layer formation in cerebral cortex|forebrain radial glial cell differentiation|lateral ganglionic eminence cell proliferation|melanocyte differentiation|lung development|prostate gland development|positive regulation of chondrocyte differentiation|T cell differentiation in thymus|histone acetyltransferase binding|limb morphogenesis|mediator complex binding|wound healing|positive regulation of protein import into nucleus|odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|histone deacetylase binding|negative regulation of apoptotic process|intracellular membrane-bounded organelle|nose morphogenesis|tongue development|response to estrogen|negative thymic T cell selection|negative regulation of neuron differentiation|positive regulation of osteoblast differentiation|negative regulation of smoothened signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of alpha-beta T cell differentiation|negative regulation of alpha-beta T cell differentiation|metal ion binding|embryonic digestive tract morphogenesis|embryonic digestive tract development|developmental growth|camera-type eye morphogenesis|embryonic neurocranium morphogenesis|oligodendrocyte differentiation|roof of mouth development|frontal suture morphogenesis|lambdoid suture morphogenesis|sagittal suture morphogenesis|mammary gland specification|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|artery development|anterior semicircular canal development|lateral semicircular canal development|cell differentiation involved in kidney development|thymocyte apoptotic process|vocalization behavior|negative regulation of canonical Wnt signaling pathway|liver regeneration|ciliary tip|ciliary base|larynx morphogenesis|regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|regulation of bone development|sequence-specific double-stranded DNA binding" "hsa04024,hsa04340,hsa05200,hsa05217" cAMP signaling pathway|Hedgehog signaling pathway|Pathways in cancer|Basal cell carcinoma GLI4 133.1094247 125.8900798 140.3287696 1.114692832 0.156646212 0.724829561 1 5.032600886 5.515931659 2738 GLI family zinc finger 4 "GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0008150,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" zf-C2H2 GLIPR1 5122.676433 5279.060041 4966.292825 0.940753238 -0.088111746 0.714297552 1 47.88132764 44.29075506 11010 GLI pathogenesis related 1 "GO:0005515,GO:0005615,GO:0005886,GO:0016020,GO:0016021,GO:0019216,GO:0035577,GO:0043312" protein binding|extracellular space|plasma membrane|membrane|integral component of membrane|regulation of lipid metabolic process|azurophil granule membrane|neutrophil degranulation GLIPR1L1 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.035402508 256710 GLIPR1 like 1 "GO:0001669,GO:0005615,GO:0005886,GO:0007338,GO:0031225,GO:0045121" acrosomal vesicle|extracellular space|plasma membrane|single fertilization|anchored component of membrane|membrane raft GLIPR1L2 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.056696709 0 144321 GLIPR1 like 2 "GO:0005615,GO:0007339,GO:0016021" extracellular space|binding of sperm to zona pellucida|integral component of membrane GLIPR2 876.85175 802.1591035 951.5443964 1.186229007 0.246382555 0.323112735 1 20.27937331 23.65343659 152007 GLI pathogenesis related 2 "GO:0000139,GO:0005615,GO:0010634,GO:0010718,GO:0042803,GO:0070062,GO:0070374" Golgi membrane|extracellular space|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|protein homodimerization activity|extracellular exosome|positive regulation of ERK1 and ERK2 cascade GLIS1 27.62065769 31.21241648 24.0288989 0.769850643 -0.377349516 0.642993258 1 0.185971788 0.140774736 148979 GLIS family zinc finger 1 "GO:0000122,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0030154,GO:0045944,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 GLIS2 450.8237308 493.1561804 408.4912813 0.828320312 -0.271739328 0.333375594 1 5.653885921 4.604861064 84662 GLIS family zinc finger 2 "GO:0000122,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007417,GO:0016607,GO:0043433,GO:0045879,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0060994,GO:0061005,GO:0061484,GO:0097730,GO:1900182,GO:1990837" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|central nervous system development|nuclear speck|negative regulation of DNA-binding transcription factor activity|negative regulation of smoothened signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|regulation of transcription from RNA polymerase II promoter involved in kidney development|cell differentiation involved in kidney development|hematopoietic stem cell homeostasis|non-motile cilium|positive regulation of protein localization to nucleus|sequence-specific double-stranded DNA binding" zf-C2H2 GLIS3 494.1795445 533.7323218 454.6267672 0.851787963 -0.231433752 0.400107608 1 2.136216668 1.789155042 169792 GLIS family zinc finger 3 "GO:0000122,GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0006366,GO:0045944,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 GLMN 217.0067812 234.0931236 199.9204388 0.85402098 -0.227656583 0.523852603 1 4.013209046 3.370012416 11146 "glomulin, FKBP associated protein" "GO:0001570,GO:0001819,GO:0001843,GO:0005102,GO:0005171,GO:0005515,GO:0005737,GO:0007166,GO:0008285,GO:0031397,GO:0031461,GO:0031462,GO:0031463,GO:0031464,GO:0031625,GO:0032434,GO:0032743,GO:0040029,GO:0042130,GO:0042327,GO:0042692,GO:0055105" "vasculogenesis|positive regulation of cytokine production|neural tube closure|signaling receptor binding|hepatocyte growth factor receptor binding|protein binding|cytoplasm|cell surface receptor signaling pathway|negative regulation of cell population proliferation|negative regulation of protein ubiquitination|cullin-RING ubiquitin ligase complex|Cul2-RING ubiquitin ligase complex|Cul3-RING ubiquitin ligase complex|Cul4A-RING E3 ubiquitin ligase complex|ubiquitin protein ligase binding|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of interleukin-2 production|regulation of gene expression, epigenetic|negative regulation of T cell proliferation|positive regulation of phosphorylation|muscle cell differentiation|ubiquitin-protein transferase inhibitor activity" hsa05131 Shigellosis GLMP 551.3085732 582.6317743 519.9853722 0.892476853 -0.164113343 0.542483489 1 16.19478488 14.21161138 112770 glycosylated lysosomal membrane protein "GO:0005634,GO:0005764,GO:0005765,GO:0005829,GO:0016021,GO:0045944,GO:0050821,GO:0061462" nucleus|lysosome|lysosomal membrane|cytosol|integral component of membrane|positive regulation of transcription by RNA polymerase II|protein stabilization|protein localization to lysosome GLO1 4705.735235 4085.705317 5325.765152 1.303511815 0.382403659 0.110490743 1 108.1580276 138.6260693 2739 glyoxalase I "GO:0004462,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006090,GO:0006357,GO:0006749,GO:0008270,GO:0009438,GO:0030316,GO:0043066,GO:0070062" lactoylglutathione lyase activity|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|carbohydrate metabolic process|pyruvate metabolic process|regulation of transcription by RNA polymerase II|glutathione metabolic process|zinc ion binding|methylglyoxal metabolic process|osteoclast differentiation|negative regulation of apoptotic process|extracellular exosome hsa00620 Pyruvate metabolism GLOD4 1273.266374 1254.739142 1291.793605 1.029531606 0.041988121 0.864791367 1 18.93753448 19.17053791 51031 glyoxalase domain containing 4 "GO:0005739,GO:0045296,GO:0070062" mitochondrion|cadherin binding|extracellular exosome GLRA3 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.005850893 0.015944185 8001 glycine receptor alpha 3 "GO:0004888,GO:0005254,GO:0005886,GO:0005887,GO:0007165,GO:0007218,GO:0007268,GO:0016594,GO:0016934,GO:0016935,GO:0022852,GO:0030425,GO:0030594,GO:0034220,GO:0042391,GO:0043005,GO:0043200,GO:0043204,GO:0045202,GO:0045211,GO:0046872,GO:0050877,GO:0051260,GO:0060012,GO:0060079,GO:1902476" "transmembrane signaling receptor activity|chloride channel activity|plasma membrane|integral component of plasma membrane|signal transduction|neuropeptide signaling pathway|chemical synaptic transmission|glycine binding|extracellularly glycine-gated chloride channel activity|glycine-gated chloride channel complex|glycine-gated chloride ion channel activity|dendrite|neurotransmitter receptor activity|ion transmembrane transport|regulation of membrane potential|neuron projection|response to amino acid|perikaryon|synapse|postsynaptic membrane|metal ion binding|nervous system process|protein homooligomerization|synaptic transmission, glycinergic|excitatory postsynaptic potential|chloride transmembrane transport" hsa04080 Neuroactive ligand-receptor interaction GLRB 99.67717188 106.122216 93.23212773 0.87853544 -0.18682761 0.70504205 1 2.259995062 1.95226134 2743 glycine receptor beta "GO:0001964,GO:0004888,GO:0005254,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0006811,GO:0007165,GO:0007218,GO:0007268,GO:0007340,GO:0007399,GO:0007601,GO:0007628,GO:0016594,GO:0016933,GO:0016934,GO:0016935,GO:0030425,GO:0030594,GO:0034220,GO:0042391,GO:0043005,GO:0043200,GO:0044877,GO:0045202,GO:0045211,GO:0050877,GO:0060012,GO:0060013,GO:0060079,GO:0097112,GO:0098690,GO:0098982,GO:1902476,GO:1904315" "startle response|transmembrane signaling receptor activity|chloride channel activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|ion transport|signal transduction|neuropeptide signaling pathway|chemical synaptic transmission|acrosome reaction|nervous system development|visual perception|adult walking behavior|glycine binding|extracellularly glycine-gated ion channel activity|extracellularly glycine-gated chloride channel activity|glycine-gated chloride channel complex|dendrite|neurotransmitter receptor activity|ion transmembrane transport|regulation of membrane potential|neuron projection|response to amino acid|protein-containing complex binding|synapse|postsynaptic membrane|nervous system process|synaptic transmission, glycinergic|righting reflex|excitatory postsynaptic potential|gamma-aminobutyric acid receptor clustering|glycinergic synapse|GABA-ergic synapse|chloride transmembrane transport|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential" hsa04080 Neuroactive ligand-receptor interaction GLRX 643.723584 523.328183 764.118985 1.460114341 0.54608135 0.035549478 0.951348545 29.61724633 42.52092686 2745 glutaredoxin "GO:0005515,GO:0005634,GO:0005829,GO:0009055,GO:0015038,GO:0015949,GO:0022900,GO:0045838,GO:0047485,GO:0070062,GO:0080058,GO:0097573,GO:2000651" protein binding|nucleus|cytosol|electron transfer activity|glutathione disulfide oxidoreductase activity|nucleobase-containing small molecule interconversion|electron transport chain|positive regulation of membrane potential|protein N-terminus binding|extracellular exosome|protein deglutathionylation|glutathione oxidoreductase activity|positive regulation of sodium ion transmembrane transporter activity GLRX2 187.1021205 206.0019488 168.2022923 0.816508258 -0.292460618 0.436971723 1 8.555599525 6.868821139 51022 glutaredoxin 2 "GO:0003756,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0006355,GO:0006749,GO:0006915,GO:0007568,GO:0008794,GO:0009055,GO:0009266,GO:0009966,GO:0010033,GO:0015035,GO:0015038,GO:0018215,GO:0022900,GO:0030154,GO:0030425,GO:0042262,GO:0042542,GO:0043025,GO:0043231,GO:0045454,GO:0046872,GO:0051537,GO:0051775,GO:0071451" "protein disulfide isomerase activity|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|regulation of transcription, DNA-templated|glutathione metabolic process|apoptotic process|aging|arsenate reductase (glutaredoxin) activity|electron transfer activity|response to temperature stimulus|regulation of signal transduction|response to organic substance|protein disulfide oxidoreductase activity|glutathione disulfide oxidoreductase activity|protein phosphopantetheinylation|electron transport chain|cell differentiation|dendrite|DNA protection|response to hydrogen peroxide|neuronal cell body|intracellular membrane-bounded organelle|cell redox homeostasis|metal ion binding|2 iron, 2 sulfur cluster binding|response to redox state|cellular response to superoxide" GLRX3 1380.712665 1262.02204 1499.403291 1.188095964 0.248651369 0.299916771 1 17.18158081 20.07177676 10539 glutaredoxin 3 "GO:0002026,GO:0003723,GO:0005080,GO:0005515,GO:0005634,GO:0005829,GO:0005938,GO:0006879,GO:0010614,GO:0015035,GO:0030018,GO:0030425,GO:0042802,GO:0044571,GO:0046872,GO:0051536,GO:0055114,GO:0097428" regulation of the force of heart contraction|RNA binding|protein kinase C binding|protein binding|nucleus|cytosol|cell cortex|cellular iron ion homeostasis|negative regulation of cardiac muscle hypertrophy|protein disulfide oxidoreductase activity|Z disc|dendrite|identical protein binding|[2Fe-2S] cluster assembly|metal ion binding|iron-sulfur cluster binding|oxidation-reduction process|protein maturation by iron-sulfur cluster transfer GLRX5 775.9108673 751.1788233 800.6429113 1.065848619 0.092002549 0.719415125 1 36.34545167 38.09050895 51218 glutaredoxin 5 "GO:0005515,GO:0005634,GO:0005739,GO:0005759,GO:0015035,GO:0030097,GO:0030425,GO:0043025,GO:0044281,GO:0044571,GO:0046872,GO:0051537,GO:0055114,GO:0106034,GO:0106035" "protein binding|nucleus|mitochondrion|mitochondrial matrix|protein disulfide oxidoreductase activity|hemopoiesis|dendrite|neuronal cell body|small molecule metabolic process|[2Fe-2S] cluster assembly|metal ion binding|2 iron, 2 sulfur cluster binding|oxidation-reduction process|protein maturation by [2Fe-2S] cluster transfer|protein maturation by [4Fe-4S] cluster transfer" GLS 2504.048771 2491.791249 2516.306293 1.009838322 0.014124331 0.954177885 1 11.7402948 11.65740885 2744 glutaminase "GO:0001967,GO:0002087,GO:0004359,GO:0005515,GO:0005739,GO:0005759,GO:0005829,GO:0006537,GO:0006543,GO:0007268,GO:0008652,GO:0014047,GO:0045202,GO:0051289,GO:0090461" suckling behavior|regulation of respiratory gaseous exchange by nervous system process|glutaminase activity|protein binding|mitochondrion|mitochondrial matrix|cytosol|glutamate biosynthetic process|glutamine catabolic process|chemical synaptic transmission|cellular amino acid biosynthetic process|glutamate secretion|synapse|protein homotetramerization|glutamate homeostasis "hsa00220,hsa00250,hsa00471,hsa04724,hsa04727,hsa04964,hsa05206,hsa05230" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|D-Glutamine and D-glutamate metabolism|Glutamatergic synapse|GABAergic synapse|Proximal tubule bicarbonate reclamation|MicroRNAs in cancer|Central carbon metabolism in cancer" GLS2 16.09181664 18.72744989 13.45618338 0.718527267 -0.476885189 0.64781365 1 0.401063235 0.283352654 27165 glutaminase 2 "GO:0004359,GO:0005515,GO:0005739,GO:0005759,GO:0006520,GO:0006537,GO:0006543,GO:0008652,GO:0014047,GO:0042981,GO:0072593" glutaminase activity|protein binding|mitochondrion|mitochondrial matrix|cellular amino acid metabolic process|glutamate biosynthetic process|glutamine catabolic process|cellular amino acid biosynthetic process|glutamate secretion|regulation of apoptotic process|reactive oxygen species metabolic process "hsa00220,hsa00250,hsa00471,hsa04724,hsa04727,hsa04964,hsa05206,hsa05230" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|D-Glutamine and D-glutamate metabolism|Glutamatergic synapse|GABAergic synapse|Proximal tubule bicarbonate reclamation|MicroRNAs in cancer|Central carbon metabolism in cancer" GLT8D1 1389.010824 1341.093495 1436.928154 1.071460088 0.099578111 0.679649634 1 29.92127717 31.52298273 55830 glycosyltransferase 8 domain containing 1 "GO:0005794,GO:0016020,GO:0016021,GO:0016757" "Golgi apparatus|membrane|integral component of membrane|transferase activity, transferring glycosyl groups" GLT8D2 467.2923298 471.3074888 463.2771708 0.982961616 -0.024793014 0.937082538 1 7.860254516 7.597038837 83468 glycosyltransferase 8 domain containing 2 "GO:0005794,GO:0016021,GO:0016757" "Golgi apparatus|integral component of membrane|transferase activity, transferring glycosyl groups" GLTP 1619.172463 1428.488261 1809.856665 1.266973425 0.341386265 0.15129967 1 28.86626014 35.96078847 51228 glycolipid transfer protein "GO:0005515,GO:0005829,GO:0006687,GO:0008289,GO:0016020,GO:0017089,GO:0035627,GO:0042802,GO:0046836,GO:0051861,GO:0120009,GO:0120013,GO:1902387,GO:1902388,GO:1902389" protein binding|cytosol|glycosphingolipid metabolic process|lipid binding|membrane|glycolipid transfer activity|ceramide transport|identical protein binding|glycolipid transport|glycolipid binding|intermembrane lipid transfer|lipid transfer activity|ceramide 1-phosphate binding|ceramide 1-phosphate transfer activity|ceramide 1-phosphate transport GLUD1 6743.335289 6696.103749 6790.566829 1.014107171 0.020210125 0.934558652 1 92.38850831 92.12404259 2746 glutamate dehydrogenase 1 "GO:0004352,GO:0004353,GO:0005515,GO:0005524,GO:0005525,GO:0005737,GO:0005739,GO:0005759,GO:0005783,GO:0006537,GO:0006538,GO:0006541,GO:0008652,GO:0021762,GO:0032024,GO:0042802,GO:0043531,GO:0055114,GO:0070403,GO:0070728,GO:0072350" glutamate dehydrogenase (NAD+) activity|glutamate dehydrogenase [NAD(P)+] activity|protein binding|ATP binding|GTP binding|cytoplasm|mitochondrion|mitochondrial matrix|endoplasmic reticulum|glutamate biosynthetic process|glutamate catabolic process|glutamine metabolic process|cellular amino acid biosynthetic process|substantia nigra development|positive regulation of insulin secretion|identical protein binding|ADP binding|oxidation-reduction process|NAD+ binding|leucine binding|tricarboxylic acid metabolic process "hsa00220,hsa00250,hsa00471,hsa00910,hsa04217,hsa04964" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|D-Glutamine and D-glutamate metabolism|Nitrogen metabolism|Necroptosis|Proximal tubule bicarbonate reclamation" GLUD2 12.45036805 11.44455271 13.45618338 1.175771891 0.233608194 0.899941244 1 0.245784605 0.28415083 2747 glutamate dehydrogenase 2 "GO:0004352,GO:0004353,GO:0005525,GO:0005739,GO:0005759,GO:0005829,GO:0006536,GO:0006537,GO:0006538,GO:0043531,GO:0055114,GO:0070728" glutamate dehydrogenase (NAD+) activity|glutamate dehydrogenase [NAD(P)+] activity|GTP binding|mitochondrion|mitochondrial matrix|cytosol|glutamate metabolic process|glutamate biosynthetic process|glutamate catabolic process|ADP binding|oxidation-reduction process|leucine binding "hsa00220,hsa00250,hsa00471,hsa00910,hsa04217,hsa04964" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|D-Glutamine and D-glutamate metabolism|Nitrogen metabolism|Necroptosis|Proximal tubule bicarbonate reclamation" GLUL 1613.081622 1735.410356 1490.752888 0.859020394 -0.219235712 0.357077625 1 11.18141509 9.44433586 2752 glutamate-ammonia ligase "GO:0001504,GO:0001525,GO:0004356,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0005886,GO:0006538,GO:0006542,GO:0008283,GO:0008652,GO:0010594,GO:0018215,GO:0018345,GO:0019706,GO:0042254,GO:0042802,GO:0046872,GO:0070062,GO:1903670,GO:1904749" neurotransmitter uptake|angiogenesis|glutamate-ammonia ligase activity|protein binding|ATP binding|nucleus|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|plasma membrane|glutamate catabolic process|glutamine biosynthetic process|cell population proliferation|cellular amino acid biosynthetic process|regulation of endothelial cell migration|protein phosphopantetheinylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|ribosome biogenesis|identical protein binding|metal ion binding|extracellular exosome|regulation of sprouting angiogenesis|regulation of protein localization to nucleolus "hsa00220,hsa00250,hsa00630,hsa00910,hsa04217,hsa04724,hsa04727" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|Glyoxylate and dicarboxylate metabolism|Nitrogen metabolism|Necroptosis|Glutamatergic synapse|GABAergic synapse" GLYCTK 133.1043943 138.3750464 127.8337421 0.923820772 -0.11431511 0.802502476 1 1.784635549 1.621094907 132158 glycerate kinase "GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005794,GO:0005829,GO:0006468,GO:0008887,GO:0061624" protein binding|ATP binding|cytoplasm|mitochondrion|Golgi apparatus|cytosol|protein phosphorylation|glycerate kinase activity|fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate "hsa00030,hsa00260,hsa00561,hsa00630" "Pentose phosphate pathway|Glycine, serine and threonine metabolism|Glycerolipid metabolism|Glyoxylate and dicarboxylate metabolism" GLYR1 1328.744848 1424.326605 1233.163092 0.865786742 -0.207916386 0.387438707 1 16.21106699 13.80046469 84656 glyoxylate reductase 1 homolog "GO:0000786,GO:0003677,GO:0003682,GO:0005515,GO:0005654,GO:0005829,GO:0016616,GO:0031491,GO:0035064,GO:0035066,GO:0042393,GO:0045944,GO:0050661,GO:0051287,GO:0055114" "nucleosome|DNA binding|chromatin binding|protein binding|nucleoplasm|cytosol|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|nucleosome binding|methylated histone binding|positive regulation of histone acetylation|histone binding|positive regulation of transcription by RNA polymerase II|NADP binding|NAD binding|oxidation-reduction process" other GM2A 1185.811857 1128.849063 1242.774651 1.100921897 0.138712123 0.568693632 1 16.78590129 18.17072908 2760 GM2 ganglioside activator "GO:0005319,GO:0005576,GO:0005829,GO:0006687,GO:0006689,GO:0006869,GO:0007611,GO:0009313,GO:0009898,GO:0016004,GO:0016323,GO:0016324,GO:0019915,GO:0030290,GO:0032428,GO:0035578,GO:0043202,GO:0043231,GO:0043312,GO:0050885,GO:0051345,GO:0070062" lipid transporter activity|extracellular region|cytosol|glycosphingolipid metabolic process|ganglioside catabolic process|lipid transport|learning or memory|oligosaccharide catabolic process|cytoplasmic side of plasma membrane|phospholipase activator activity|basolateral plasma membrane|apical plasma membrane|lipid storage|sphingolipid activator protein activity|beta-N-acetylgalactosaminidase activity|azurophil granule lumen|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|neuromuscular process controlling balance|positive regulation of hydrolase activity|extracellular exosome hsa04142 Lysosome GMCL1 500.10058 449.4587973 550.7423628 1.225345607 0.293188717 0.284245699 1 7.308589257 8.805688776 64395 "germ cell-less 1, spermatogenesis associated" "GO:0005515,GO:0005634,GO:0007275,GO:0007281,GO:0007283,GO:0016363,GO:0042802" protein binding|nucleus|multicellular organism development|germ cell development|spermatogenesis|nuclear matrix|identical protein binding GMDS 353.4406228 358.9427895 347.9384561 0.969342375 -0.044921774 0.89019817 1 1.832244569 1.746352137 2762 "GDP-mannose 4,6-dehydratase" "GO:0005515,GO:0005737,GO:0005829,GO:0007219,GO:0008446,GO:0019673,GO:0042351,GO:0042802,GO:0070062,GO:0070401" "protein binding|cytoplasm|cytosol|Notch signaling pathway|GDP-mannose 4,6-dehydratase activity|GDP-mannose metabolic process|'de novo' GDP-L-fucose biosynthetic process|identical protein binding|extracellular exosome|NADP+ binding" "hsa00051,hsa00520" Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism GMEB1 192.4381681 182.0724295 202.8039067 1.113863902 0.155572967 0.682894765 1 3.618946341 3.963560137 10691 glucocorticoid modulatory element binding protein 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0042802,GO:0045944,GO:0046872,GO:0051008,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|identical protein binding|positive regulation of transcription by RNA polymerase II|metal ion binding|Hsp27 protein binding|sequence-specific double-stranded DNA binding" SAND GMEB2 654.9744079 629.450399 680.4984168 1.081099349 0.112499108 0.66777669 1 7.239786835 7.695955783 26205 glucocorticoid modulatory element binding protein 2 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006366,GO:0042802,GO:0045944,GO:0046872,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|identical protein binding|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" SAND GMFB 1990.997738 1979.907619 2002.087856 1.011202663 0.016072168 0.948127118 1 25.86634778 25.71843252 2764 glia maturation factor beta "GO:0003779,GO:0004860,GO:0006468,GO:0006469,GO:0007165,GO:0007399,GO:0008047,GO:0008083,GO:0034316,GO:0071846,GO:0071933" actin binding|protein kinase inhibitor activity|protein phosphorylation|negative regulation of protein kinase activity|signal transduction|nervous system development|enzyme activator activity|growth factor activity|negative regulation of Arp2/3 complex-mediated actin nucleation|actin filament debranching|Arp2/3 complex binding GMFG 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.361726233 0.164289161 9535 glia maturation factor gamma "GO:0003779,GO:0004860,GO:0005576,GO:0006468,GO:0006469,GO:0007165,GO:0008047,GO:0008083,GO:0034316,GO:0034774,GO:0043312,GO:0071846,GO:0071933,GO:1904813,GO:2000249" actin binding|protein kinase inhibitor activity|extracellular region|protein phosphorylation|negative regulation of protein kinase activity|signal transduction|enzyme activator activity|growth factor activity|negative regulation of Arp2/3 complex-mediated actin nucleation|secretory granule lumen|neutrophil degranulation|actin filament debranching|Arp2/3 complex binding|ficolin-1-rich granule lumen|regulation of actin cytoskeleton reorganization GMIP 381.4776918 350.6194785 412.3359051 1.176021101 0.233913946 0.427408696 1 5.248784615 6.069389998 51291 GEM interacting protein "GO:0005096,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0034260,GO:0035556,GO:0046872,GO:0051056,GO:0090630" GTPase activator activity|protein binding|nucleoplasm|cytosol|plasma membrane|negative regulation of GTPase activity|intracellular signal transduction|metal ion binding|regulation of small GTPase mediated signal transduction|activation of GTPase activity GMNC 4.483717655 4.161655531 4.80577978 1.154775965 0.207612985 1 1 0.060982951 0.069243235 647309 geminin coiled-coil domain containing "GO:0003682,GO:0005515,GO:0005634,GO:0006270,GO:0007049,GO:0008156,GO:0045786,GO:0060271" chromatin binding|protein binding|nucleus|DNA replication initiation|cell cycle|negative regulation of DNA replication|negative regulation of cell cycle|cilium assembly GMNN 499.2878791 478.590386 519.9853722 1.08649356 0.119679623 0.666398638 1 6.435245475 6.874853577 51053 geminin DNA replication inhibitor "GO:0000082,GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006275,GO:0008156,GO:0009887,GO:0035563,GO:0042826,GO:0045786,GO:0045892,GO:0070491,GO:0071163,GO:2000104" "G1/S transition of mitotic cell cycle|chromatin binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of DNA replication|negative regulation of DNA replication|animal organ morphogenesis|positive regulation of chromatin binding|histone deacetylase binding|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|repressing transcription factor binding|DNA replication preinitiation complex assembly|negative regulation of DNA-dependent DNA replication" GMPPA 1112.545738 1173.58686 1051.504616 0.89597511 -0.15846944 0.516683428 1 41.1512311 36.25350129 29926 GDP-mannose pyrophosphorylase A "GO:0005515,GO:0005737,GO:0009058,GO:0016779,GO:0070062" protein binding|cytoplasm|biosynthetic process|nucleotidyltransferase activity|extracellular exosome "hsa00051,hsa00520" Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism GMPPB 591.484009 564.9447383 618.0232797 1.093953511 0.12955143 0.627009278 1 9.348856545 10.05607585 29925 GDP-mannose pyrophosphorylase B "GO:0004475,GO:0005515,GO:0005525,GO:0005737,GO:0009298" mannose-1-phosphate guanylyltransferase activity|protein binding|GTP binding|cytoplasm|GDP-mannose biosynthetic process "hsa00051,hsa00520" Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism GMPR 88.51002191 90.51600779 86.50403604 0.95567666 -0.065405509 0.917351833 1 2.925907313 2.749430353 2766 guanosine monophosphate reductase "GO:0003920,GO:0005829,GO:0006144,GO:0006163,GO:0009409,GO:0043101,GO:0046872,GO:0055114,GO:1902560" GMP reductase activity|cytosol|purine nucleobase metabolic process|purine nucleotide metabolic process|response to cold|purine-containing compound salvage|metal ion binding|oxidation-reduction process|GMP reductase complex hsa00230 Purine metabolism GMPR2 1829.559979 1690.672559 1968.447398 1.164298425 0.219460887 0.354773881 1 47.5635673 54.45150754 51292 guanosine monophosphate reductase 2 "GO:0003920,GO:0005515,GO:0005829,GO:0006144,GO:0043101,GO:0046037,GO:0046872,GO:0055114,GO:1902560" GMP reductase activity|protein binding|cytosol|purine nucleobase metabolic process|purine-containing compound salvage|GMP metabolic process|metal ion binding|oxidation-reduction process|GMP reductase complex hsa00230 Purine metabolism GMPS 3092.13475 2942.29046 3241.97904 1.101855539 0.139935088 0.555085478 1 17.46658889 18.92360769 8833 guanine monophosphate synthase "GO:0003921,GO:0003922,GO:0005524,GO:0005829,GO:0006177,GO:0006541,GO:0009113,GO:0009168,GO:0016462" GMP synthase activity|GMP synthase (glutamine-hydrolyzing) activity|ATP binding|cytosol|GMP biosynthetic process|glutamine metabolic process|purine nucleobase biosynthetic process|purine ribonucleoside monophosphate biosynthetic process|pyrophosphatase activity "hsa00230,hsa00983" Purine metabolism|Drug metabolism - other enzymes GNA11 1578.135251 1398.316258 1757.954244 1.257193595 0.330206827 0.165572417 1 17.81039826 22.01643357 2767 G protein subunit alpha 11 "GO:0001501,GO:0001508,GO:0001664,GO:0001750,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005765,GO:0005834,GO:0005886,GO:0007165,GO:0007186,GO:0007188,GO:0007213,GO:0007507,GO:0007603,GO:0009649,GO:0030168,GO:0031683,GO:0031826,GO:0045202,GO:0045634,GO:0046872,GO:0048066,GO:0060158,GO:0070062,GO:0071467" "skeletal system development|action potential|G protein-coupled receptor binding|photoreceptor outer segment|GTPase activity|protein binding|GTP binding|cytoplasm|lysosomal membrane|heterotrimeric G-protein complex|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|G protein-coupled acetylcholine receptor signaling pathway|heart development|phototransduction, visible light|entrainment of circadian clock|platelet activation|G-protein beta/gamma-subunit complex binding|type 2A serotonin receptor binding|synapse|regulation of melanocyte differentiation|metal ion binding|developmental pigmentation|phospholipase C-activating dopamine receptor signaling pathway|extracellular exosome|cellular response to pH" "hsa04020,hsa04022,hsa04270,hsa04540,hsa04725,hsa04730,hsa04911,hsa04912,hsa04925,hsa04927,hsa04928,hsa04929,hsa04934,hsa04935,hsa05142,hsa05146,hsa05163,hsa05170,hsa05200" "Calcium signaling pathway|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Gap junction|Cholinergic synapse|Long-term depression|Insulin secretion|GnRH signaling pathway|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Cushing syndrome|Growth hormone synthesis, secretion and action|Chagas disease|Amoebiasis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer" GNA12 3561.200937 3384.46636 3737.935513 1.104438666 0.143313302 0.546501592 1 33.76126154 36.66329116 2768 G protein subunit alpha 12 "GO:0001664,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005834,GO:0005886,GO:0005925,GO:0007186,GO:0007188,GO:0007266,GO:0007596,GO:0010762,GO:0016328,GO:0030168,GO:0031526,GO:0031683,GO:0031752,GO:0032006,GO:0032434,GO:0042493,GO:0046872" G protein-coupled receptor binding|GTPase activity|protein binding|GTP binding|cytoplasm|heterotrimeric G-protein complex|plasma membrane|focal adhesion|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|Rho protein signal transduction|blood coagulation|regulation of fibroblast migration|lateral plasma membrane|platelet activation|brush border membrane|G-protein beta/gamma-subunit complex binding|D5 dopamine receptor binding|regulation of TOR signaling|regulation of proteasomal ubiquitin-dependent protein catabolic process|response to drug|metal ion binding "hsa04010,hsa04022,hsa04071,hsa04072,hsa04270,hsa04730,hsa04810,hsa04928,hsa05130,hsa05163,hsa05200" "MAPK signaling pathway|cGMP-PKG signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Vascular smooth muscle contraction|Long-term depression|Regulation of actin cytoskeleton|Parathyroid hormone synthesis, secretion and action|Pathogenic Escherichia coli infection|Human cytomegalovirus infection|Pathways in cancer" GNA13 2554.518291 2668.661609 2440.374972 0.914456507 -0.129013541 0.585916751 1 19.93024983 17.92037014 10672 G protein subunit alpha 13 "GO:0001664,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005829,GO:0005834,GO:0005886,GO:0005925,GO:0007165,GO:0007186,GO:0007188,GO:0007189,GO:0007204,GO:0007266,GO:0016020,GO:0030168,GO:0031526,GO:0031584,GO:0031683,GO:0031752,GO:0042470,GO:0043065,GO:0046872,GO:0051056,GO:0070062" G protein-coupled receptor binding|GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|cytosol|heterotrimeric G-protein complex|plasma membrane|focal adhesion|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|Rho protein signal transduction|membrane|platelet activation|brush border membrane|activation of phospholipase D activity|G-protein beta/gamma-subunit complex binding|D5 dopamine receptor binding|melanosome|positive regulation of apoptotic process|metal ion binding|regulation of small GTPase mediated signal transduction|extracellular exosome "hsa04022,hsa04071,hsa04072,hsa04270,hsa04371,hsa04611,hsa04730,hsa04810,hsa04928,hsa05130,hsa05163,hsa05200" "cGMP-PKG signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Vascular smooth muscle contraction|Apelin signaling pathway|Platelet activation|Long-term depression|Regulation of actin cytoskeleton|Parathyroid hormone synthesis, secretion and action|Pathogenic Escherichia coli infection|Human cytomegalovirus infection|Pathways in cancer" GNA15 954.6858751 751.1788233 1158.192927 1.541833836 0.624647294 0.011538425 0.638817649 17.63705816 26.7383681 2769 G protein subunit alpha 15 "GO:0001508,GO:0001664,GO:0003924,GO:0005525,GO:0005834,GO:0005886,GO:0007186,GO:0007188,GO:0007202,GO:0007207,GO:0030168,GO:0031683,GO:0031826,GO:0045202,GO:0046872,GO:0051482,GO:0060158" action potential|G protein-coupled receptor binding|GTPase activity|GTP binding|heterotrimeric G-protein complex|plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|activation of phospholipase C activity|phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway|platelet activation|G-protein beta/gamma-subunit complex binding|type 2A serotonin receptor binding|synapse|metal ion binding|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|phospholipase C-activating dopamine receptor signaling pathway "hsa04020,hsa04926,hsa05142,hsa05146" Calcium signaling pathway|Relaxin signaling pathway|Chagas disease|Amoebiasis GNAI1 1052.519379 960.3020137 1144.736744 1.192059089 0.25345575 0.300788338 1 4.941144766 5.79157307 2770 G protein subunit alpha i1 "GO:0000287,GO:0001664,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005765,GO:0005813,GO:0005834,GO:0005886,GO:0006457,GO:0007049,GO:0007186,GO:0007188,GO:0007193,GO:0019003,GO:0030496,GO:0031683,GO:0031821,GO:0032794,GO:0043434,GO:0043949,GO:0045121,GO:0050805,GO:0051301,GO:0060236,GO:0070062,GO:0099738,GO:1904322,GO:1904778" magnesium ion binding|G protein-coupled receptor binding|GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|lysosomal membrane|centrosome|heterotrimeric G-protein complex|plasma membrane|protein folding|cell cycle|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|GDP binding|midbody|G-protein beta/gamma-subunit complex binding|G protein-coupled serotonin receptor binding|GTPase activating protein binding|response to peptide hormone|regulation of cAMP-mediated signaling|membrane raft|negative regulation of synaptic transmission|cell division|regulation of mitotic spindle organization|extracellular exosome|cell cortex region|cellular response to forskolin|positive regulation of protein localization to cell cortex "hsa04015,hsa04022,hsa04024,hsa04062,hsa04071,hsa04261,hsa04360,hsa04371,hsa04540,hsa04611,hsa04670,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04914,hsa04915,hsa04916,hsa04921,hsa04923,hsa04924,hsa04926,hsa04928,hsa04934,hsa04935,hsa04971,hsa05012,hsa05030,hsa05032,hsa05034,hsa05133,hsa05142,hsa05145,hsa05163,hsa05170,hsa05200" "Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Adrenergic signaling in cardiomyocytes|Axon guidance|Apelin signaling pathway|Gap junction|Platelet activation|Leukocyte transendothelial migration|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Gastric acid secretion|Parkinson disease|Cocaine addiction|Morphine addiction|Alcoholism|Pertussis|Chagas disease|Toxoplasmosis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer" GNAI2 7999.673106 7026.955363 8972.390849 1.276853258 0.352592733 0.153180447 1 121.089988 152.0268873 2771 G protein subunit alpha i2 "GO:0001664,GO:0001973,GO:0003924,GO:0005515,GO:0005525,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005834,GO:0005886,GO:0006457,GO:0007049,GO:0007165,GO:0007186,GO:0007188,GO:0007189,GO:0007193,GO:0007194,GO:0007213,GO:0007214,GO:0007584,GO:0008283,GO:0008284,GO:0016020,GO:0030335,GO:0030425,GO:0030496,GO:0031683,GO:0032930,GO:0033864,GO:0035810,GO:0035815,GO:0044297,GO:0045121,GO:0045202,GO:0045955,GO:0046628,GO:0046872,GO:0050805,GO:0051301,GO:0051924,GO:0070062,GO:0070374,GO:0140199,GO:1903561,GO:1903614,GO:1904707,GO:2000179,GO:2001234" G protein-coupled receptor binding|G protein-coupled adenosine receptor signaling pathway|GTPase activity|protein binding|GTP binding|nucleoplasm|cytoplasm|centrosome|cytosol|heterotrimeric G-protein complex|plasma membrane|protein folding|cell cycle|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|G protein-coupled acetylcholine receptor signaling pathway|gamma-aminobutyric acid signaling pathway|response to nutrient|cell population proliferation|positive regulation of cell population proliferation|membrane|positive regulation of cell migration|dendrite|midbody|G-protein beta/gamma-subunit complex binding|positive regulation of superoxide anion generation|positive regulation of NAD(P)H oxidase activity|positive regulation of urine volume|positive regulation of renal sodium excretion|cell body|membrane raft|synapse|negative regulation of calcium ion-dependent exocytosis|positive regulation of insulin receptor signaling pathway|metal ion binding|negative regulation of synaptic transmission|cell division|regulation of calcium ion transport|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process|extracellular vesicle|negative regulation of protein tyrosine phosphatase activity|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of neural precursor cell proliferation|negative regulation of apoptotic signaling pathway "hsa04015,hsa04022,hsa04024,hsa04062,hsa04071,hsa04261,hsa04360,hsa04371,hsa04540,hsa04611,hsa04670,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04914,hsa04915,hsa04916,hsa04921,hsa04923,hsa04924,hsa04926,hsa04928,hsa04934,hsa04935,hsa04971,hsa05012,hsa05030,hsa05032,hsa05034,hsa05133,hsa05142,hsa05145,hsa05163,hsa05170,hsa05200" "Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Adrenergic signaling in cardiomyocytes|Axon guidance|Apelin signaling pathway|Gap junction|Platelet activation|Leukocyte transendothelial migration|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Gastric acid secretion|Parkinson disease|Cocaine addiction|Morphine addiction|Alcoholism|Pertussis|Chagas disease|Toxoplasmosis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer" GNAI3 3584.450504 3628.963623 3539.937386 0.975467862 -0.035833753 0.881140794 1 21.41432096 20.53943306 2773 G protein subunit alpha i3 "GO:0000139,GO:0001664,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005765,GO:0005789,GO:0005813,GO:0005834,GO:0005886,GO:0006457,GO:0006906,GO:0007049,GO:0007186,GO:0007188,GO:0007193,GO:0007194,GO:0007212,GO:0007420,GO:0016020,GO:0016239,GO:0019003,GO:0019904,GO:0030496,GO:0031683,GO:0031821,GO:0032794,GO:0032930,GO:0033864,GO:0042588,GO:0045121,GO:0046039,GO:0046872,GO:0051301,GO:0070062,GO:1904707,GO:2001234" Golgi membrane|G protein-coupled receptor binding|GTPase activity|protein binding|GTP binding|cytoplasm|lysosomal membrane|endoplasmic reticulum membrane|centrosome|heterotrimeric G-protein complex|plasma membrane|protein folding|vesicle fusion|cell cycle|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|dopamine receptor signaling pathway|brain development|membrane|positive regulation of macroautophagy|GDP binding|protein domain specific binding|midbody|G-protein beta/gamma-subunit complex binding|G protein-coupled serotonin receptor binding|GTPase activating protein binding|positive regulation of superoxide anion generation|positive regulation of NAD(P)H oxidase activity|zymogen granule|membrane raft|GTP metabolic process|metal ion binding|cell division|extracellular exosome|positive regulation of vascular associated smooth muscle cell proliferation|negative regulation of apoptotic signaling pathway "hsa04015,hsa04022,hsa04024,hsa04062,hsa04071,hsa04261,hsa04360,hsa04371,hsa04540,hsa04611,hsa04670,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04914,hsa04915,hsa04916,hsa04921,hsa04923,hsa04924,hsa04926,hsa04928,hsa04934,hsa04935,hsa04971,hsa05012,hsa05030,hsa05032,hsa05034,hsa05133,hsa05142,hsa05145,hsa05163,hsa05170,hsa05200" "Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Adrenergic signaling in cardiomyocytes|Axon guidance|Apelin signaling pathway|Gap junction|Platelet activation|Leukocyte transendothelial migration|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Gastric acid secretion|Parkinson disease|Cocaine addiction|Morphine addiction|Alcoholism|Pertussis|Chagas disease|Toxoplasmosis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer" GNAL 7.56533034 9.363724944 5.766935736 0.615880514 -0.699277611 0.654804973 1 0.06186244 0.037462322 2774 G protein subunit alpha L "GO:0001664,GO:0003924,GO:0005515,GO:0005525,GO:0005834,GO:0005886,GO:0007165,GO:0007188,GO:0007189,GO:0007191,GO:0007193,GO:0007606,GO:0031683,GO:0046872,GO:0070062" G protein-coupled receptor binding|GTPase activity|protein binding|GTP binding|heterotrimeric G-protein complex|plasma membrane|signal transduction|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|adenylate cyclase-activating dopamine receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|sensory perception of chemical stimulus|G-protein beta/gamma-subunit complex binding|metal ion binding|extracellular exosome "hsa04020,hsa04728,hsa04740,hsa05012,hsa05142,hsa05146" Calcium signaling pathway|Dopaminergic synapse|Olfactory transduction|Parkinson disease|Chagas disease|Amoebiasis GNAO1 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.020900242 0.012656656 2775 G protein subunit alpha o1 "GO:0001664,GO:0003924,GO:0005515,GO:0005525,GO:0005834,GO:0005886,GO:0006457,GO:0006936,GO:0007188,GO:0007212,GO:0007223,GO:0007568,GO:0007626,GO:0008016,GO:0030425,GO:0030900,GO:0031175,GO:0031683,GO:0031821,GO:0031852,GO:0032794,GO:0034097,GO:0042475,GO:0042493,GO:0042542,GO:0043209,GO:0043278,GO:0043547,GO:0044297,GO:0046872,GO:0051430,GO:0051926" "G protein-coupled receptor binding|GTPase activity|protein binding|GTP binding|heterotrimeric G-protein complex|plasma membrane|protein folding|muscle contraction|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|dopamine receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|aging|locomotory behavior|regulation of heart contraction|dendrite|forebrain development|neuron projection development|G-protein beta/gamma-subunit complex binding|G protein-coupled serotonin receptor binding|mu-type opioid receptor binding|GTPase activating protein binding|response to cytokine|odontogenesis of dentin-containing tooth|response to drug|response to hydrogen peroxide|myelin sheath|response to morphine|positive regulation of GTPase activity|cell body|metal ion binding|corticotropin-releasing hormone receptor 1 binding|negative regulation of calcium ion transport" "hsa04015,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04915,hsa04916,hsa04921,hsa04926,hsa05032,hsa05034,hsa05142,hsa05145,hsa05163,hsa05170" Rap1 signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Relaxin signaling pathway|Morphine addiction|Alcoholism|Chagas disease|Toxoplasmosis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection GNAQ 2397.197528 2399.194413 2395.200642 0.99833537 -0.002403555 0.993899216 1 18.39399459 18.05608917 2776 G protein subunit alpha q "GO:0001508,GO:0001664,GO:0001750,GO:0003924,GO:0005096,GO:0005515,GO:0005525,GO:0005737,GO:0005765,GO:0005794,GO:0005834,GO:0005886,GO:0006469,GO:0007186,GO:0007188,GO:0007189,GO:0007202,GO:0007213,GO:0007215,GO:0007596,GO:0007603,GO:0009649,GO:0030168,GO:0031683,GO:0031826,GO:0031965,GO:0043547,GO:0045202,GO:0046872,GO:0050821,GO:0060828,GO:0070062" "action potential|G protein-coupled receptor binding|photoreceptor outer segment|GTPase activity|GTPase activator activity|protein binding|GTP binding|cytoplasm|lysosomal membrane|Golgi apparatus|heterotrimeric G-protein complex|plasma membrane|negative regulation of protein kinase activity|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of phospholipase C activity|G protein-coupled acetylcholine receptor signaling pathway|glutamate receptor signaling pathway|blood coagulation|phototransduction, visible light|entrainment of circadian clock|platelet activation|G-protein beta/gamma-subunit complex binding|type 2A serotonin receptor binding|nuclear membrane|positive regulation of GTPase activity|synapse|metal ion binding|protein stabilization|regulation of canonical Wnt signaling pathway|extracellular exosome" "hsa04015,hsa04020,hsa04022,hsa04062,hsa04071,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04750,hsa04911,hsa04912,hsa04915,hsa04916,hsa04918,hsa04921,hsa04922,hsa04924,hsa04925,hsa04927,hsa04928,hsa04929,hsa04934,hsa04935,hsa04961,hsa04970,hsa04971,hsa04972,hsa05010,hsa05016,hsa05017,hsa05022,hsa05135,hsa05142,hsa05143,hsa05146,hsa05163,hsa05170,hsa05200" "Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Alzheimer disease|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Yersinia infection|Chagas disease|African trypanosomiasis|Amoebiasis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer" GNAS 22857.62589 21231.7261 24483.52567 1.153157569 0.205589659 0.461163059 1 160.7003545 182.211871 2778 GNAS complex locus "GO:0001664,GO:0001894,GO:0001958,GO:0003924,GO:0005159,GO:0005515,GO:0005525,GO:0005829,GO:0005834,GO:0006112,GO:0006306,GO:0007188,GO:0007189,GO:0007191,GO:0007606,GO:0010856,GO:0016020,GO:0016324,GO:0030425,GO:0031683,GO:0031698,GO:0031748,GO:0031852,GO:0035116,GO:0035255,GO:0035264,GO:0040032,GO:0042493,GO:0043588,GO:0045669,GO:0045672,GO:0046872,GO:0048589,GO:0048701,GO:0050790,GO:0051216,GO:0051430,GO:0060348,GO:0070062,GO:0070527,GO:0071514,GO:0120162,GO:2000828" G protein-coupled receptor binding|tissue homeostasis|endochondral ossification|GTPase activity|insulin-like growth factor receptor binding|protein binding|GTP binding|cytosol|heterotrimeric G-protein complex|energy reserve metabolic process|DNA methylation|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|adenylate cyclase-activating dopamine receptor signaling pathway|sensory perception of chemical stimulus|adenylate cyclase activator activity|membrane|apical plasma membrane|dendrite|G-protein beta/gamma-subunit complex binding|beta-2 adrenergic receptor binding|D1 dopamine receptor binding|mu-type opioid receptor binding|embryonic hindlimb morphogenesis|ionotropic glutamate receptor binding|multicellular organism growth|post-embryonic body morphogenesis|response to drug|skin development|positive regulation of osteoblast differentiation|positive regulation of osteoclast differentiation|metal ion binding|developmental growth|embryonic cranial skeleton morphogenesis|regulation of catalytic activity|cartilage development|corticotropin-releasing hormone receptor 1 binding|bone development|extracellular exosome|platelet aggregation|genetic imprinting|positive regulation of cold-induced thermogenesis|regulation of parathyroid hormone secretion "hsa01522,hsa04015,hsa04020,hsa04024,hsa04072,hsa04261,hsa04270,hsa04540,hsa04611,hsa04713,hsa04714,hsa04724,hsa04726,hsa04728,hsa04730,hsa04750,hsa04911,hsa04912,hsa04913,hsa04915,hsa04916,hsa04918,hsa04921,hsa04922,hsa04923,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa04961,hsa04962,hsa04970,hsa04971,hsa04972,hsa04976,hsa05012,hsa05030,hsa05031,hsa05032,hsa05034,hsa05110,hsa05142,hsa05146,hsa05163,hsa05165,hsa05200,hsa05414" "Endocrine resistance|Rap1 signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Glutamatergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Vasopressin-regulated water reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Parkinson disease|Cocaine addiction|Amphetamine addiction|Morphine addiction|Alcoholism|Vibrio cholerae infection|Chagas disease|Amoebiasis|Human cytomegalovirus infection|Human papillomavirus infection|Pathways in cancer|Dilated cardiomyopathy" GNAZ 85.24535567 42.65696919 127.8337421 2.996784455 1.583415321 0.001757146 0.266035882 0.118273278 0.348508454 2781 G protein subunit alpha z "GO:0001664,GO:0003924,GO:0005515,GO:0005525,GO:0005635,GO:0005783,GO:0005829,GO:0005834,GO:0005886,GO:0006457,GO:0007186,GO:0007188,GO:0007193,GO:0031683,GO:0031821,GO:0046872" G protein-coupled receptor binding|GTPase activity|protein binding|GTP binding|nuclear envelope|endoplasmic reticulum|cytosol|heterotrimeric G-protein complex|plasma membrane|protein folding|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|G-protein beta/gamma-subunit complex binding|G protein-coupled serotonin receptor binding|metal ion binding hsa04730 Long-term depression GNB1 12914.70145 12103.1347 13726.26821 1.134108522 0.181558698 0.481525442 1 198.0748403 220.8793456 2782 G protein subunit beta 1 "GO:0001917,GO:0003924,GO:0005515,GO:0005737,GO:0005765,GO:0005829,GO:0005834,GO:0005886,GO:0006457,GO:0007165,GO:0007186,GO:0007191,GO:0007200,GO:0007204,GO:0007213,GO:0007223,GO:0007265,GO:0008283,GO:0010659,GO:0016020,GO:0016056,GO:0030168,GO:0030425,GO:0030507,GO:0031682,GO:0042622,GO:0044297,GO:0044877,GO:0045202,GO:0047391,GO:0050909,GO:0051020,GO:0060041,GO:0070062,GO:0071380,GO:0071456,GO:0071870,GO:0097381,GO:1903561" "photoreceptor inner segment|GTPase activity|protein binding|cytoplasm|lysosomal membrane|cytosol|heterotrimeric G-protein complex|plasma membrane|protein folding|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-activating dopamine receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|G protein-coupled acetylcholine receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|Ras protein signal transduction|cell population proliferation|cardiac muscle cell apoptotic process|membrane|rhodopsin mediated signaling pathway|platelet activation|dendrite|spectrin binding|G-protein gamma-subunit binding|photoreceptor outer segment membrane|cell body|protein-containing complex binding|synapse|alkylglycerophosphoethanolamine phosphodiesterase activity|sensory perception of taste|GTPase binding|retina development in camera-type eye|extracellular exosome|cellular response to prostaglandin E stimulus|cellular response to hypoxia|cellular response to catecholamine stimulus|photoreceptor disc membrane|extracellular vesicle" "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04740,hsa04744,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Olfactory transduction|Phototransduction|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNB1L 68.61824084 60.34400519 76.89247648 1.274235547 0.34963199 0.525061996 1 0.484861284 0.607488978 54584 G protein subunit beta 1 like "GO:0003674,GO:0007186,GO:0009898,GO:0035556" molecular_function|G protein-coupled receptor signaling pathway|cytoplasmic side of plasma membrane|intracellular signal transduction GNB2 4431.152216 4018.078415 4844.226018 1.205607636 0.26976046 0.25895612 1 128.8686659 152.765224 2783 G protein subunit beta 2 "GO:0003924,GO:0005246,GO:0005515,GO:0005615,GO:0005737,GO:0005765,GO:0005829,GO:0005834,GO:0005886,GO:0005925,GO:0006457,GO:0007186,GO:0016020,GO:0031682,GO:0031982,GO:0044297,GO:0044877,GO:0048471,GO:0051020,GO:0070062" GTPase activity|calcium channel regulator activity|protein binding|extracellular space|cytoplasm|lysosomal membrane|cytosol|heterotrimeric G-protein complex|plasma membrane|focal adhesion|protein folding|G protein-coupled receptor signaling pathway|membrane|G-protein gamma-subunit binding|vesicle|cell body|protein-containing complex binding|perinuclear region of cytoplasm|GTPase binding|extracellular exosome "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNB3 56.92585351 56.18234966 57.66935736 1.026467524 0.037687984 0.982246003 1 1.809504371 1.82631644 2784 G protein subunit beta 3 "GO:0003924,GO:0005515,GO:0005737,GO:0005829,GO:0005834,GO:0005886,GO:0006457,GO:0006884,GO:0007186,GO:0008217,GO:0010468,GO:0010906,GO:0030425,GO:0030507,GO:0031682,GO:0032350,GO:0044297,GO:0045598,GO:0051020,GO:0060259,GO:0070062,GO:0090181,GO:0090207,GO:0090325,GO:1903725" GTPase activity|protein binding|cytoplasm|cytosol|heterotrimeric G-protein complex|plasma membrane|protein folding|cell volume homeostasis|G protein-coupled receptor signaling pathway|regulation of blood pressure|regulation of gene expression|regulation of glucose metabolic process|dendrite|spectrin binding|G-protein gamma-subunit binding|regulation of hormone metabolic process|cell body|regulation of fat cell differentiation|GTPase binding|regulation of feeding behavior|extracellular exosome|regulation of cholesterol metabolic process|regulation of triglyceride metabolic process|regulation of locomotion involved in locomotory behavior|regulation of phospholipid metabolic process "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04742,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Taste transduction|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNB4 1682.477965 1753.097392 1611.858538 0.919434679 -0.121181012 0.611182202 1 14.08393584 12.73257071 59345 G protein subunit beta 4 "GO:0005515,GO:0005737,GO:0005765,GO:0005829,GO:0005834,GO:0006457,GO:0007186,GO:0021762,GO:0031682,GO:0044877,GO:0070062" protein binding|cytoplasm|lysosomal membrane|cytosol|heterotrimeric G-protein complex|protein folding|G protein-coupled receptor signaling pathway|substantia nigra development|G-protein gamma-subunit binding|protein-containing complex binding|extracellular exosome "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNB5 887.647148 845.8564866 929.4378094 1.098812652 0.135945427 0.586942588 1 3.861904874 4.172500545 10681 G protein subunit beta 5 "GO:0003924,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005834,GO:0006457,GO:0007165,GO:0007186,GO:0007212,GO:0031682,GO:0043547,GO:0051087,GO:0098793,GO:1901386,GO:1902773" GTPase activity|GTPase activator activity|protein binding|nucleus|cytoplasm|cytosol|heterotrimeric G-protein complex|protein folding|signal transduction|G protein-coupled receptor signaling pathway|dopamine receptor signaling pathway|G-protein gamma-subunit binding|positive regulation of GTPase activity|chaperone binding|presynapse|negative regulation of voltage-gated calcium channel activity|GTPase activator complex "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNE 1855.355861 1976.786377 1733.925345 0.877143512 -0.18911519 0.425193124 1 19.35733133 16.69503437 10020 glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase "GO:0004553,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006045,GO:0006047,GO:0006054,GO:0007155,GO:0008761,GO:0009384,GO:0046835,GO:0046872" "hydrolase activity, hydrolyzing O-glycosyl compounds|protein binding|ATP binding|cytoplasm|cytosol|N-acetylglucosamine biosynthetic process|UDP-N-acetylglucosamine metabolic process|N-acetylneuraminate metabolic process|cell adhesion|UDP-N-acetylglucosamine 2-epimerase activity|N-acylmannosamine kinase activity|carbohydrate phosphorylation|metal ion binding" hsa00520 Amino sugar and nucleotide sugar metabolism GNG11 2545.950217 2166.141704 2925.75873 1.35067744 0.43368318 0.066764571 1 38.29181899 50.85443361 2791 G protein subunit gamma 11 "GO:0003924,GO:0005515,GO:0005834,GO:0005886,GO:0007165,GO:0007186,GO:0031680,GO:0031681" GTPase activity|protein binding|heterotrimeric G-protein complex|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|G-protein beta/gamma-subunit complex|G-protein beta-subunit binding "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG12 6256.318526 6375.656273 6136.980779 0.962564561 -0.055044787 0.821093892 1 71.347674 67.5275302 55970 G protein subunit gamma 12 "GO:0005515,GO:0005834,GO:0005884,GO:0005886,GO:0007165,GO:0007186,GO:0021987,GO:0030165,GO:0031680,GO:0031681,GO:0032496,GO:0042301,GO:0070062" protein binding|heterotrimeric G-protein complex|actin filament|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|cerebral cortex development|PDZ domain binding|G-protein beta/gamma-subunit complex|G-protein beta-subunit binding|response to lipopolysaccharide|phosphate ion binding|extracellular exosome "hsa04010,hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04810,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" MAPK signaling pathway|Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Regulation of actin cytoskeleton|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG2 26.62490319 17.687036 35.56277037 2.010668738 1.007675414 0.189583361 1 0.177329439 0.350584365 54331 G protein subunit gamma 2 "GO:0005515,GO:0005834,GO:0005886,GO:0006457,GO:0007186,GO:0007191,GO:0007223,GO:0016020,GO:0030168,GO:0031680,GO:0031681,GO:0070062,GO:0071380,GO:0071870" "protein binding|heterotrimeric G-protein complex|plasma membrane|protein folding|G protein-coupled receptor signaling pathway|adenylate cyclase-activating dopamine receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|membrane|platelet activation|G-protein beta/gamma-subunit complex|G-protein beta-subunit binding|extracellular exosome|cellular response to prostaglandin E stimulus|cellular response to catecholamine stimulus" "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG4 275.9442654 267.3863678 284.502163 1.064011473 0.089513707 0.792099853 1 2.817358147 2.947538918 2786 G protein subunit gamma 4 "GO:0005515,GO:0005834,GO:0005886,GO:0007186,GO:0008277,GO:0030308,GO:0031680,GO:0031681,GO:0070062" protein binding|heterotrimeric G-protein complex|plasma membrane|G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|negative regulation of cell growth|G-protein beta/gamma-subunit complex|G-protein beta-subunit binding|extracellular exosome "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG5 1918.987111 1691.712973 2146.26125 1.268691134 0.343340884 0.147113007 1 112.0144071 139.7336386 2787 G protein subunit gamma 5 "GO:0003924,GO:0005515,GO:0005834,GO:0005886,GO:0007165,GO:0007186,GO:0016020,GO:0030165,GO:0031680,GO:0031681,GO:0070062" GTPase activity|protein binding|heterotrimeric G-protein complex|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|membrane|PDZ domain binding|G-protein beta/gamma-subunit complex|G-protein beta-subunit binding|extracellular exosome "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG7 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.034349675 2788 G protein subunit gamma 7 "GO:0005515,GO:0005834,GO:0005886,GO:0007186,GO:0008277,GO:0031680,GO:0031681,GO:0070062" protein binding|heterotrimeric G-protein complex|plasma membrane|G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|G-protein beta/gamma-subunit complex|G-protein beta-subunit binding|extracellular exosome "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04740,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Olfactory transduction|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG8 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.059195071 0.026885273 94235 G protein subunit gamma 8 "GO:0003924,GO:0005515,GO:0005834,GO:0005886,GO:0007186,GO:0007399,GO:0031680,GO:0031681,GO:0035176,GO:0043584,GO:0071444" GTPase activity|protein binding|heterotrimeric G-protein complex|plasma membrane|G protein-coupled receptor signaling pathway|nervous system development|G-protein beta/gamma-subunit complex|G-protein beta-subunit binding|social behavior|nose development|cellular response to pheromone "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNGT1 2.962725795 2.080827765 3.844623824 1.847641543 0.88568489 0.829811711 1 0.168002955 0.305214961 2792 G protein subunit gamma transducin 1 "GO:0001917,GO:0003924,GO:0005515,GO:0005834,GO:0005886,GO:0007165,GO:0007186,GO:0008104,GO:0010659,GO:0016056,GO:0031680,GO:0031681,GO:0042462,GO:0071456,GO:0097381" photoreceptor inner segment|GTPase activity|protein binding|heterotrimeric G-protein complex|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|protein localization|cardiac muscle cell apoptotic process|rhodopsin mediated signaling pathway|G-protein beta/gamma-subunit complex|G-protein beta-subunit binding|eye photoreceptor cell development|cellular response to hypoxia|photoreceptor disc membrane "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04744,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Phototransduction|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNGT2 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.127151527 2793 G protein subunit gamma transducin 2 "GO:0003924,GO:0005834,GO:0005886,GO:0007186,GO:0007602,GO:0031680,GO:0031681" GTPase activity|heterotrimeric G-protein complex|plasma membrane|G protein-coupled receptor signaling pathway|phototransduction|G-protein beta/gamma-subunit complex|G-protein beta-subunit binding "hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNL1 2137.920621 2014.241277 2261.599964 1.122804895 0.167107258 0.48029366 1 14.6015152 16.12031043 2794 G protein nucleolar 1 (putative) "GO:0002456,GO:0003924,GO:0005198,GO:0005525,GO:0005615,GO:0005634,GO:0006974,GO:0007165" T cell mediated immunity|GTPase activity|structural molecule activity|GTP binding|extracellular space|nucleus|cellular response to DNA damage stimulus|signal transduction GNL2 1286.148244 1189.193068 1383.103421 1.163060447 0.217926079 0.366115276 1 22.32326711 25.5288482 29889 G protein nucleolar 2 "GO:0003723,GO:0003924,GO:0005525,GO:0005634,GO:0005730,GO:0008150,GO:0016020,GO:0042254" RNA binding|GTPase activity|GTP binding|nucleus|nucleolus|biological_process|membrane|ribosome biogenesis hsa03008 Ribosome biogenesis in eukaryotes GNL3 1890.329842 1847.775056 1932.884628 1.04606057 0.06496639 0.785628027 1 48.22120227 49.59821478 26354 G protein nucleolar 3 "GO:0003723,GO:0005515,GO:0005525,GO:0005615,GO:0005634,GO:0005694,GO:0005730,GO:0008283,GO:0016020,GO:0016604,GO:0017145,GO:0019827,GO:0030496,GO:0032206,GO:0033235,GO:0042127,GO:0048027,GO:1902895,GO:1904816" "RNA binding|protein binding|GTP binding|extracellular space|nucleus|chromosome|nucleolus|cell population proliferation|membrane|nuclear body|stem cell division|stem cell population maintenance|midbody|positive regulation of telomere maintenance|positive regulation of protein sumoylation|regulation of cell population proliferation|mRNA 5'-UTR binding|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of protein localization to chromosome, telomeric region" hsa03008 Ribosome biogenesis in eukaryotes GNL3L 753.4325284 779.2699981 727.5950587 0.933688016 -0.098987528 0.699853948 1 4.854465689 4.456710246 54552 G protein nucleolar 3 like "GO:0003723,GO:0005515,GO:0005525,GO:0005654,GO:0005697,GO:0005730,GO:0005829,GO:0016020,GO:0031334,GO:0031397,GO:0031647,GO:0032091,GO:0032211,GO:0033234,GO:0042254,GO:1904816" "RNA binding|protein binding|GTP binding|nucleoplasm|telomerase holoenzyme complex|nucleolus|cytosol|membrane|positive regulation of protein-containing complex assembly|negative regulation of protein ubiquitination|regulation of protein stability|negative regulation of protein binding|negative regulation of telomere maintenance via telomerase|negative regulation of protein sumoylation|ribosome biogenesis|positive regulation of protein localization to chromosome, telomeric region" hsa03008 Ribosome biogenesis in eukaryotes GNPAT 1119.2342 1172.546446 1065.921955 0.90906587 -0.13754326 0.573803061 1 24.47268235 21.87500217 8443 glyceronephosphate O-acyltransferase "GO:0005777,GO:0005778,GO:0005782,GO:0005829,GO:0006625,GO:0006631,GO:0006654,GO:0007416,GO:0007584,GO:0008611,GO:0008654,GO:0016020,GO:0016287,GO:0021587,GO:0030913,GO:0031966,GO:0042493,GO:0042594,GO:0061024,GO:0070542" peroxisome|peroxisomal membrane|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid metabolic process|phosphatidic acid biosynthetic process|synapse assembly|response to nutrient|ether lipid biosynthetic process|phospholipid biosynthetic process|membrane|glycerone-phosphate O-acyltransferase activity|cerebellum morphogenesis|paranodal junction assembly|mitochondrial membrane|response to drug|response to starvation|membrane organization|response to fatty acid "hsa00564,hsa04146" Glycerophospholipid metabolism|Peroxisome GNPDA1 2206.343904 2359.658686 2053.029122 0.870053425 -0.200824103 0.395878881 1 47.75527008 40.85435941 10007 glucosamine-6-phosphate deaminase 1 "GO:0004342,GO:0005515,GO:0005737,GO:0005829,GO:0005975,GO:0006043,GO:0006046,GO:0006048,GO:0006091,GO:0007338,GO:0019262,GO:0042802,GO:0070062" glucosamine-6-phosphate deaminase activity|protein binding|cytoplasm|cytosol|carbohydrate metabolic process|glucosamine catabolic process|N-acetylglucosamine catabolic process|UDP-N-acetylglucosamine biosynthetic process|generation of precursor metabolites and energy|single fertilization|N-acetylneuraminate catabolic process|identical protein binding|extracellular exosome hsa00520 Amino sugar and nucleotide sugar metabolism GNPDA2 917.5222406 847.9373144 987.1071668 1.164127525 0.219249107 0.377273197 1 20.24736287 23.17609182 132789 glucosamine-6-phosphate deaminase 2 "GO:0004342,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005975,GO:0006043,GO:0006046,GO:0006048,GO:0019262,GO:0042802" glucosamine-6-phosphate deaminase activity|protein binding|nucleus|cytoplasm|cytosol|carbohydrate metabolic process|glucosamine catabolic process|N-acetylglucosamine catabolic process|UDP-N-acetylglucosamine biosynthetic process|N-acetylneuraminate catabolic process|identical protein binding hsa00520 Amino sugar and nucleotide sugar metabolism GNPNAT1 1468.715729 1616.803174 1320.628284 0.816814505 -0.29191961 0.22173811 1 20.87728377 16.76751155 64841 glucosamine-phosphate N-acetyltransferase 1 "GO:0000139,GO:0001889,GO:0004343,GO:0005515,GO:0005783,GO:0005793,GO:0005794,GO:0005829,GO:0006041,GO:0006044,GO:0006048,GO:0008080,GO:0010008,GO:0042802,GO:0048029" Golgi membrane|liver development|glucosamine 6-phosphate N-acetyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|glucosamine metabolic process|N-acetylglucosamine metabolic process|UDP-N-acetylglucosamine biosynthetic process|N-acetyltransferase activity|endosome membrane|identical protein binding|monosaccharide binding hsa00520 Amino sugar and nucleotide sugar metabolism GNPTAB 1117.043932 1241.213762 992.8741025 0.799921926 -0.322068899 0.185928337 1 10.6003036 8.33752374 79158 N-acetylglucosamine-1-phosphate transferase subunits alpha and beta "GO:0000139,GO:0003976,GO:0005509,GO:0005515,GO:0005794,GO:0007040,GO:0016021,GO:0016256,GO:0033299,GO:0046835" Golgi membrane|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity|calcium ion binding|protein binding|Golgi apparatus|lysosome organization|integral component of membrane|N-glycan processing to lysosome|secretion of lysosomal enzymes|carbohydrate phosphorylation hsa04142 Lysosome GNPTG 614.9725793 613.8441908 616.1009678 1.003676466 0.005294292 0.990969658 1 23.50052817 23.19223177 84572 N-acetylglucosamine-1-phosphate transferase subunit gamma "GO:0000139,GO:0003976,GO:0005794,GO:0042803,GO:0046835,GO:0070062" Golgi membrane|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity|Golgi apparatus|protein homodimerization activity|carbohydrate phosphorylation|extracellular exosome hsa04142 Lysosome GNRH1 24.94036506 23.9295193 25.95121081 1.084485254 0.117010436 0.935419701 1 2.543973037 2.712734768 2796 gonadotropin releasing hormone 1 "GO:0000003,GO:0005179,GO:0005183,GO:0005576,GO:0005615,GO:0005739,GO:0005798,GO:0007165,GO:0007186,GO:0007267,GO:0007275,GO:0007565,GO:0007568,GO:0008285,GO:0010468,GO:0030238,GO:0030425,GO:0031530,GO:0031960,GO:0032496,GO:0033087,GO:0033574,GO:0034695,GO:0035864,GO:0043066,GO:0043204,GO:0043679,GO:0044849,GO:0045471,GO:0098556,GO:1990008,GO:1990637,GO:2000354,GO:2001223" reproduction|hormone activity|gonadotropin hormone-releasing hormone activity|extracellular region|extracellular space|mitochondrion|Golgi-associated vesicle|signal transduction|G protein-coupled receptor signaling pathway|cell-cell signaling|multicellular organism development|female pregnancy|aging|negative regulation of cell population proliferation|regulation of gene expression|male sex determination|dendrite|gonadotropin-releasing hormone receptor binding|response to corticosteroid|response to lipopolysaccharide|negative regulation of immature T cell proliferation|response to testosterone|response to prostaglandin E|response to potassium ion|negative regulation of apoptotic process|perikaryon|axon terminus|estrous cycle|response to ethanol|cytoplasmic side of rough endoplasmic reticulum membrane|neurosecretory vesicle|response to prolactin|regulation of ovarian follicle development|negative regulation of neuron migration "hsa04080,hsa04912,hsa04929" Neuroactive ligand-receptor interaction|GnRH signaling pathway|GnRH secretion GNRH2 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.054938961 0 2797 gonadotropin releasing hormone 2 "GO:0000003,GO:0005179,GO:0005183,GO:0005576,GO:0005615,GO:0007165,GO:0007186,GO:0007275,GO:0031530" reproduction|hormone activity|gonadotropin hormone-releasing hormone activity|extracellular region|extracellular space|signal transduction|G protein-coupled receptor signaling pathway|multicellular organism development|gonadotropin-releasing hormone receptor binding "hsa04080,hsa04912,hsa04929" Neuroactive ligand-receptor interaction|GnRH signaling pathway|GnRH secretion GNS 6281.262693 6588.941119 5973.584267 0.906607626 -0.141449798 0.560319037 1 69.20678558 61.69347377 2799 glucosamine (N-acetyl)-6-sulfatase "GO:0005515,GO:0005539,GO:0005576,GO:0006027,GO:0008449,GO:0008484,GO:0035578,GO:0042340,GO:0043202,GO:0043312,GO:0046872,GO:0070062,GO:1904813" protein binding|glycosaminoglycan binding|extracellular region|glycosaminoglycan catabolic process|N-acetylglucosamine-6-sulfatase activity|sulfuric ester hydrolase activity|azurophil granule lumen|keratan sulfate catabolic process|lysosomal lumen|neutrophil degranulation|metal ion binding|extracellular exosome|ficolin-1-rich granule lumen "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome GOLGA1 372.6385898 421.3676225 323.9095572 0.768710124 -0.379488427 0.198347009 1 4.21748229 3.187770496 2800 golgin A1 "GO:0000139,GO:0001669,GO:0005515,GO:0005794,GO:0005802,GO:0005829,GO:0048471" Golgi membrane|acrosomal vesicle|protein binding|Golgi apparatus|trans-Golgi network|cytosol|perinuclear region of cytoplasm GOLGA2 2701.184507 2544.852357 2857.516657 1.122861469 0.167179949 0.48000388 1 31.15716748 34.39975321 2801 golgin A2 "GO:0000137,GO:0000139,GO:0000922,GO:0005515,GO:0005794,GO:0005801,GO:0005874,GO:0006486,GO:0006888,GO:0007020,GO:0007030,GO:0007098,GO:0008017,GO:0008356,GO:0010507,GO:0015031,GO:0019901,GO:0019905,GO:0030134,GO:0032091,GO:0032580,GO:0033116,GO:0042802,GO:0045296,GO:0048208,GO:0051225,GO:0051289,GO:0060050,GO:0061676,GO:0072686,GO:0090161,GO:0090166,GO:0090306,GO:0090307,GO:1904668" Golgi cis cisterna|Golgi membrane|spindle pole|protein binding|Golgi apparatus|cis-Golgi network|microtubule|protein glycosylation|endoplasmic reticulum to Golgi vesicle-mediated transport|microtubule nucleation|Golgi organization|centrosome cycle|microtubule binding|asymmetric cell division|negative regulation of autophagy|protein transport|protein kinase binding|syntaxin binding|COPII-coated ER to Golgi transport vesicle|negative regulation of protein binding|Golgi cisterna membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|identical protein binding|cadherin binding|COPII vesicle coating|spindle assembly|protein homotetramerization|positive regulation of protein glycosylation|importin-alpha family protein binding|mitotic spindle|Golgi ribbon formation|Golgi disassembly|spindle assembly involved in meiosis|mitotic spindle assembly|positive regulation of ubiquitin protein ligase activity GOLGA3 2214.099776 1995.513827 2432.685725 1.219077358 0.285789677 0.226786124 1 10.10502945 12.11267396 2802 golgin A3 "GO:0000139,GO:0005515,GO:0005654,GO:0005730,GO:0005794,GO:0005829,GO:0006891,GO:0007283,GO:0016020,GO:0017119,GO:0032580,GO:0045296,GO:0090498" Golgi membrane|protein binding|nucleoplasm|nucleolus|Golgi apparatus|cytosol|intra-Golgi vesicle-mediated transport|spermatogenesis|membrane|Golgi transport complex|Golgi cisterna membrane|cadherin binding|extrinsic component of Golgi membrane GOLGA4 2261.427932 2216.08157 2306.774294 1.040924813 0.057865865 0.808155107 1 13.50093612 13.8182938 2803 golgin A4 "GO:0000139,GO:0005515,GO:0005654,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0016192,GO:0043001,GO:0045773,GO:0051020,GO:0070062" Golgi membrane|protein binding|nucleoplasm|cytoplasm|Golgi apparatus|trans-Golgi network|cytosol|vesicle-mediated transport|Golgi to plasma membrane protein transport|positive regulation of axon extension|GTPase binding|extracellular exosome GOLGA5 1402.234264 1322.366045 1482.102484 1.120795932 0.164523625 0.493115288 1 24.56395594 27.07048485 9950 golgin A5 "GO:0000139,GO:0000301,GO:0005794,GO:0005801,GO:0007030,GO:0016020,GO:0016021,GO:0030133,GO:0031267,GO:0031985,GO:0042803,GO:0048193" "Golgi membrane|retrograde transport, vesicle recycling within Golgi|Golgi apparatus|cis-Golgi network|Golgi organization|membrane|integral component of membrane|transport vesicle|small GTPase binding|Golgi cisterna|protein homodimerization activity|Golgi vesicle transport" GOLGA6L10 36.46417569 48.89945248 24.0288989 0.491394028 -1.025047772 0.129068568 1 0.586180123 0.283225361 647042 golgin A6 family like 10 GOLGA6L9 172.1796655 167.5066351 176.8526959 1.055795168 0.078329968 0.853094633 1 1.835630647 1.905619325 440295 golgin A6 family like 9 GO:0005515 protein binding GOLGA7 699.2813167 694.9964736 703.5661598 1.012330546 0.017680436 0.951068429 1 18.00518662 17.9221929 51125 golgin A7 "GO:0000139,GO:0002178,GO:0005515,GO:0005576,GO:0005795,GO:0006612,GO:0006893,GO:0018215,GO:0018230,GO:0019706,GO:0031228,GO:0043001,GO:0043312,GO:0050821,GO:0070062,GO:1904724" Golgi membrane|palmitoyltransferase complex|protein binding|extracellular region|Golgi stack|protein targeting to membrane|Golgi to plasma membrane transport|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein-cysteine S-palmitoyltransferase activity|intrinsic component of Golgi membrane|Golgi to plasma membrane protein transport|neutrophil degranulation|protein stabilization|extracellular exosome|tertiary granule lumen GOLGA7B 112.2709645 159.183324 65.35860501 0.41058701 -1.284240111 0.004599619 0.412329403 1.241461557 0.501198381 401647 golgin A7 family member B "GO:0000139,GO:0002178,GO:0005515,GO:0006612,GO:0018215,GO:0018230,GO:0019706,GO:0019899" Golgi membrane|palmitoyltransferase complex|protein binding|protein targeting to membrane|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein-cysteine S-palmitoyltransferase activity|enzyme binding GOLGA8A 707.703393 764.7042037 650.7025822 0.850920629 -0.232903526 0.363502572 1 7.064368684 5.910627469 23015 golgin A8 family member A "GO:0000137,GO:0005794,GO:0005801,GO:0005829,GO:0007030,GO:0032580,GO:0051225" Golgi cis cisterna|Golgi apparatus|cis-Golgi network|cytosol|Golgi organization|Golgi cisterna membrane|spindle assembly GOLGA8B 1014.775787 1104.919543 924.6320297 0.836831999 -0.256990077 0.295499062 1 10.51676927 8.653500091 440270 golgin A8 family member B "GO:0000137,GO:0005794,GO:0005801,GO:0005829,GO:0007030,GO:0032580,GO:0051225" Golgi cis cisterna|Golgi apparatus|cis-Golgi network|cytosol|Golgi organization|Golgi cisterna membrane|spindle assembly GOLGA8H 79.58724599 70.74814402 88.42634795 1.249875162 0.321784005 0.537040755 1 0.727775331 0.894406912 728498 golgin A8 family member H "GO:0000137,GO:0005801,GO:0007030,GO:0032580,GO:0051225" Golgi cis cisterna|cis-Golgi network|Golgi organization|Golgi cisterna membrane|spindle assembly GOLGA8J 6.564545421 8.323311061 4.80577978 0.577387982 -0.792387015 0.636893371 1 0.073775089 0.041884049 653073 golgin A8 family member J "GO:0000137,GO:0005801,GO:0007030,GO:0032580,GO:0051225" Golgi cis cisterna|cis-Golgi network|Golgi organization|Golgi cisterna membrane|spindle assembly GOLGA8K 27.02119282 28.09117483 25.95121081 0.923820772 -0.11431511 0.930963103 1 0.289751521 0.263199237 653125 golgin A8 family member K "GO:0000137,GO:0005801,GO:0007030,GO:0032580,GO:0051225" Golgi cis cisterna|cis-Golgi network|Golgi organization|Golgi cisterna membrane|spindle assembly GOLGA8N 18.4154486 16.64662212 20.18427508 1.212514763 0.278002313 0.805315523 1 0.166710382 0.198756281 643699 golgin A8 family member N "GO:0000137,GO:0005801,GO:0007030,GO:0032580,GO:0051225" Golgi cis cisterna|cis-Golgi network|Golgi organization|Golgi cisterna membrane|spindle assembly GOLGA8O 4.003139677 4.161655531 3.844623824 0.923820772 -0.11431511 1 1 0.040581017 0.036862249 728047 golgin A8 family member O "GO:0000137,GO:0005515,GO:0005801,GO:0007030,GO:0032580,GO:0051225" Golgi cis cisterna|protein binding|cis-Golgi network|Golgi organization|Golgi cisterna membrane|spindle assembly GOLGA8Q 3.403674809 1.040413883 5.766935736 5.54292463 2.470647391 0.304382079 1 0.029239061 0.159357891 727909 golgin A8 family member Q "GO:0000137,GO:0005801,GO:0007030,GO:0032580,GO:0051225" Golgi cis cisterna|cis-Golgi network|Golgi organization|Golgi cisterna membrane|spindle assembly GOLGA8T 5.643018428 9.363724944 1.922311912 0.205293505 -2.284240111 0.166157707 1 0.083593976 0.016874129 653075 golgin A8 family member T "GO:0000137,GO:0005801,GO:0007030,GO:0032580,GO:0051225" Golgi cis cisterna|cis-Golgi network|Golgi organization|Golgi cisterna membrane|spindle assembly GOLGB1 2381.064853 2581.266843 2180.862864 0.844880827 -0.243180236 0.30364154 1 9.882171251 8.209543507 2804 golgin B1 "GO:0000139,GO:0003723,GO:0005515,GO:0005793,GO:0005794,GO:0005795,GO:0005801,GO:0006355,GO:0006888,GO:0007030,GO:0016020,GO:0016021,GO:0043565,GO:1905793" "Golgi membrane|RNA binding|protein binding|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|Golgi stack|cis-Golgi network|regulation of transcription, DNA-templated|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|membrane|integral component of membrane|sequence-specific DNA binding|protein localization to pericentriolar material" GOLIM4 1233.46772 1231.850037 1235.085403 1.002626429 0.003784169 0.991340814 1 14.18372652 13.98301024 27333 golgi integral membrane protein 4 "GO:0000139,GO:0005794,GO:0005796,GO:0005801,GO:0010008,GO:0016020,GO:0016021,GO:0030133,GO:0030139,GO:0032580" Golgi membrane|Golgi apparatus|Golgi lumen|cis-Golgi network|endosome membrane|membrane|integral component of membrane|transport vesicle|endocytic vesicle|Golgi cisterna membrane GOLM1 2071.46308 1859.219608 2283.706551 1.22831458 0.296680092 0.209799403 1 31.29080208 37.79179159 51280 golgi membrane protein 1 "GO:0005515,GO:0005615,GO:0005788,GO:0005794,GO:0005887,GO:0006997,GO:0019216,GO:0043687,GO:0044267" protein binding|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|integral component of plasma membrane|nucleus organization|regulation of lipid metabolic process|post-translational protein modification|cellular protein metabolic process GOLM2 1962.63419 1903.957405 2021.310975 1.061636657 0.086290092 0.716875443 1 25.24489625 26.35243038 113201 golgi membrane protein 2 "GO:0005794,GO:0016021" Golgi apparatus|integral component of membrane GOLPH3 2279.104907 2276.425575 2281.78424 1.002353982 0.003392087 0.99066977 1 34.14520772 33.6528661 64083 golgi phosphoprotein 3 "GO:0005515,GO:0005739,GO:0005758,GO:0005768,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0006890,GO:0007030,GO:0009101,GO:0009306,GO:0010467,GO:0010821,GO:0016477,GO:0019899,GO:0030032,GO:0031985,GO:0032008,GO:0032580,GO:0043001,GO:0043066,GO:0043231,GO:0045053,GO:0048194,GO:0050714,GO:0050901,GO:0060352,GO:0070273,GO:0072752,GO:0090161,GO:0090164" "protein binding|mitochondrion|mitochondrial intermembrane space|endosome|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|glycoprotein biosynthetic process|protein secretion|gene expression|regulation of mitochondrion organization|cell migration|enzyme binding|lamellipodium assembly|Golgi cisterna|positive regulation of TOR signaling|Golgi cisterna membrane|Golgi to plasma membrane protein transport|negative regulation of apoptotic process|intracellular membrane-bounded organelle|protein retention in Golgi apparatus|Golgi vesicle budding|positive regulation of protein secretion|leukocyte tethering or rolling|cell adhesion molecule production|phosphatidylinositol-4-phosphate binding|cellular response to rapamycin|Golgi ribbon formation|asymmetric Golgi ribbon formation" GOLPH3L 924.8190002 1026.888502 822.7494983 0.801206262 -0.319754398 0.19664118 1 13.1643411 10.37085687 55204 golgi phosphoprotein 3 like "GO:0000139,GO:0005515,GO:0005794,GO:0005802,GO:0005829,GO:0006890,GO:0007030,GO:0031985,GO:0032580,GO:0032588,GO:0043001,GO:0048194,GO:0050714,GO:0070273" "Golgi membrane|protein binding|Golgi apparatus|trans-Golgi network|cytosol|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|Golgi cisterna|Golgi cisterna membrane|trans-Golgi network membrane|Golgi to plasma membrane protein transport|Golgi vesicle budding|positive regulation of protein secretion|phosphatidylinositol-4-phosphate binding" GOLT1A 48.88497561 34.33365813 63.4362931 1.847641543 0.88568489 0.144635943 1 2.346125777 4.262262453 127845 golgi transport 1A "GO:0000137,GO:0000139,GO:0003674,GO:0005515,GO:0005635,GO:0005783,GO:0005802,GO:0006888,GO:0008150,GO:0015031,GO:0016020,GO:0016021" Golgi cis cisterna|Golgi membrane|molecular_function|protein binding|nuclear envelope|endoplasmic reticulum|trans-Golgi network|endoplasmic reticulum to Golgi vesicle-mediated transport|biological_process|protein transport|membrane|integral component of membrane GOLT1B 1813.686428 1627.207312 2000.165544 1.229201423 0.297721343 0.20922529 1 25.4516599 30.76170085 51026 golgi transport 1B "GO:0000139,GO:0005515,GO:0005783,GO:0015031,GO:0016020,GO:0016021,GO:0016192,GO:0032991,GO:0043123" Golgi membrane|protein binding|endoplasmic reticulum|protein transport|membrane|integral component of membrane|vesicle-mediated transport|protein-containing complex|positive regulation of I-kappaB kinase/NF-kappaB signaling GON4L 1211.538542 1387.912119 1035.164965 0.745843307 -0.423055527 0.080328302 1 8.531481103 6.256669412 54856 gon-4 like "GO:0003712,GO:0003714,GO:0005634,GO:0005654,GO:0006355,GO:0016604,GO:0030183,GO:0045892" "transcription coregulator activity|transcription corepressor activity|nucleus|nucleoplasm|regulation of transcription, DNA-templated|nuclear body|B cell differentiation|negative regulation of transcription, DNA-templated" GON7 266.5855709 236.1739514 296.9971904 1.257535764 0.330599431 0.315142051 1 11.20370641 13.85330014 84520 GON7 subunit of KEOPS complex "GO:0000408,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829" EKC/KEOPS complex|protein binding|nucleus|nucleoplasm|nucleolus|cytosol GOPC 984.7572694 1061.22216 908.2923784 0.855892774 -0.224498028 0.3624218 1 12.11972528 10.19960408 57120 golgi associated PDZ and coiled-coil motif containing "GO:0000139,GO:0005515,GO:0005737,GO:0005765,GO:0005794,GO:0005886,GO:0006888,GO:0006893,GO:0010360,GO:0014069,GO:0015031,GO:0016020,GO:0030140,GO:0030425,GO:0030660,GO:0032991,GO:0042802,GO:0043004,GO:0044325,GO:0045176,GO:2000009" Golgi membrane|protein binding|cytoplasm|lysosomal membrane|Golgi apparatus|plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|negative regulation of anion channel activity|postsynaptic density|protein transport|membrane|trans-Golgi network transport vesicle|dendrite|Golgi-associated vesicle membrane|protein-containing complex|identical protein binding|cytoplasmic sequestering of CFTR protein|ion channel binding|apical protein localization|negative regulation of protein localization to cell surface GORAB 324.3681703 352.7003062 296.0360344 0.839341586 -0.252670032 0.413370452 1 6.544842527 5.401434592 92344 "golgin, RAB6 interacting" "GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0031069,GO:1901622,GO:1905515" protein binding|nucleoplasm|nucleolus|cytoplasm|Golgi apparatus|cytosol|hair follicle morphogenesis|positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|non-motile cilium assembly hsa04115 p53 signaling pathway GORASP1 980.9283512 922.8471139 1039.009588 1.125874018 0.171045404 0.488792437 1 12.47167747 13.80657152 64689 golgi reassembly stacking protein 1 "GO:0000139,GO:0005515,GO:0005794,GO:0006487,GO:0006888,GO:0007030,GO:0015031,GO:0033116,GO:0046872,GO:0048208,GO:0050774,GO:0061951,GO:1904668" Golgi membrane|protein binding|Golgi apparatus|protein N-linked glycosylation|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|protein transport|endoplasmic reticulum-Golgi intermediate compartment membrane|metal ion binding|COPII vesicle coating|negative regulation of dendrite morphogenesis|establishment of protein localization to plasma membrane|positive regulation of ubiquitin protein ligase activity GORASP2 3402.33906 3162.858203 3641.819917 1.151433192 0.203430706 0.391287764 1 66.69139835 75.50570149 26003 golgi reassembly stacking protein 2 "GO:0000139,GO:0005515,GO:0005789,GO:0005794,GO:0006996,GO:0007030,GO:0007283,GO:0016020,GO:0030154,GO:0034976,GO:0061951,GO:0070925" Golgi membrane|protein binding|endoplasmic reticulum membrane|Golgi apparatus|organelle organization|Golgi organization|spermatogenesis|membrane|cell differentiation|response to endoplasmic reticulum stress|establishment of protein localization to plasma membrane|organelle assembly GOSR1 335.9366403 366.2256867 305.647594 0.834588084 -0.260863773 0.393051998 1 11.17483808 9.170322248 9527 golgi SNAP receptor complex member 1 "GO:0000139,GO:0005484,GO:0005794,GO:0005797,GO:0005801,GO:0005829,GO:0006888,GO:0006891,GO:0006906,GO:0015031,GO:0016020,GO:0016021,GO:0030133,GO:0031201,GO:0042147,GO:0048209" "Golgi membrane|SNAP receptor activity|Golgi apparatus|Golgi medial cisterna|cis-Golgi network|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|vesicle fusion|protein transport|membrane|integral component of membrane|transport vesicle|SNARE complex|retrograde transport, endosome to Golgi|regulation of vesicle targeting, to, from or within Golgi" hsa04130 SNARE interactions in vesicular transport GOSR2 767.3051231 739.7342706 794.8759756 1.074542585 0.10372266 0.685261058 1 5.245583105 5.542281523 9570 golgi SNAP receptor complex member 2 "GO:0000139,GO:0000149,GO:0005484,GO:0005515,GO:0005789,GO:0005794,GO:0005829,GO:0006623,GO:0006888,GO:0006891,GO:0006896,GO:0012507,GO:0016020,GO:0016021,GO:0031201,GO:0031902,GO:0033116,GO:0036498,GO:0042147,GO:0048208,GO:0048280" "Golgi membrane|SNARE binding|SNAP receptor activity|protein binding|endoplasmic reticulum membrane|Golgi apparatus|cytosol|protein targeting to vacuole|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|Golgi to vacuole transport|ER to Golgi transport vesicle membrane|membrane|integral component of membrane|SNARE complex|late endosome membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|IRE1-mediated unfolded protein response|retrograde transport, endosome to Golgi|COPII vesicle coating|vesicle fusion with Golgi apparatus" hsa04130 SNARE interactions in vesicular transport GOT1 2984.722442 3049.45309 2919.991794 0.957546061 -0.062586208 0.792556703 1 82.27689927 77.46557858 2805 glutamic-oxaloacetic transaminase 1 "GO:0004069,GO:0004609,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005829,GO:0006094,GO:0006103,GO:0006107,GO:0006114,GO:0006531,GO:0006532,GO:0006533,GO:0006536,GO:0007219,GO:0008652,GO:0009743,GO:0019550,GO:0019551,GO:0030170,GO:0030511,GO:0031406,GO:0032869,GO:0032966,GO:0035902,GO:0043679,GO:0046686,GO:0047801,GO:0051384,GO:0051481,GO:0051902,GO:0055089,GO:0060290,GO:0070062,GO:0071260,GO:1990267" L-aspartate:2-oxoglutarate aminotransferase activity|phosphatidylserine decarboxylase activity|nucleus|nucleoplasm|cytoplasm|lysosome|cytosol|gluconeogenesis|2-oxoglutarate metabolic process|oxaloacetate metabolic process|glycerol biosynthetic process|aspartate metabolic process|aspartate biosynthetic process|aspartate catabolic process|glutamate metabolic process|Notch signaling pathway|cellular amino acid biosynthetic process|response to carbohydrate|glutamate catabolic process to aspartate|glutamate catabolic process to 2-oxoglutarate|pyridoxal phosphate binding|positive regulation of transforming growth factor beta receptor signaling pathway|carboxylic acid binding|cellular response to insulin stimulus|negative regulation of collagen biosynthetic process|response to immobilization stress|axon terminus|response to cadmium ion|L-cysteine:2-oxoglutarate aminotransferase activity|response to glucocorticoid|negative regulation of cytosolic calcium ion concentration|negative regulation of mitochondrial depolarization|fatty acid homeostasis|transdifferentiation|extracellular exosome|cellular response to mechanical stimulus|response to transition metal nanoparticle "hsa00220,hsa00250,hsa00270,hsa00330,hsa00350,hsa00360,hsa00400" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|Cysteine and methionine metabolism|Arginine and proline metabolism|Tyrosine metabolism|Phenylalanine metabolism|Phenylalanine, tyrosine and tryptophan biosynthesis" GOT2 3948.04363 3838.086813 4058.000446 1.057297722 0.08038168 0.736299586 1 84.60621194 87.9570644 2806 glutamic-oxaloacetic transaminase 2 "GO:0003723,GO:0004069,GO:0005543,GO:0005739,GO:0005743,GO:0005759,GO:0005886,GO:0006094,GO:0006103,GO:0006107,GO:0006531,GO:0006532,GO:0006533,GO:0006536,GO:0007565,GO:0007595,GO:0008652,GO:0009986,GO:0014850,GO:0015908,GO:0016212,GO:0016597,GO:0019470,GO:0019550,GO:0019551,GO:0019899,GO:0030170,GO:0030315,GO:0032868,GO:0032991,GO:0042802,GO:0043204,GO:0043278,GO:0045471,GO:0046487,GO:0070062,GO:0097052" RNA binding|L-aspartate:2-oxoglutarate aminotransferase activity|phospholipid binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|plasma membrane|gluconeogenesis|2-oxoglutarate metabolic process|oxaloacetate metabolic process|aspartate metabolic process|aspartate biosynthetic process|aspartate catabolic process|glutamate metabolic process|female pregnancy|lactation|cellular amino acid biosynthetic process|cell surface|response to muscle activity|fatty acid transport|kynurenine-oxoglutarate transaminase activity|amino acid binding|4-hydroxyproline catabolic process|glutamate catabolic process to aspartate|glutamate catabolic process to 2-oxoglutarate|enzyme binding|pyridoxal phosphate binding|T-tubule|response to insulin|protein-containing complex|identical protein binding|perikaryon|response to morphine|response to ethanol|glyoxylate metabolic process|extracellular exosome|L-kynurenine metabolic process "hsa00220,hsa00250,hsa00270,hsa00330,hsa00350,hsa00360,hsa00400,hsa04975" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|Cysteine and methionine metabolism|Arginine and proline metabolism|Tyrosine metabolism|Phenylalanine metabolism|Phenylalanine, tyrosine and tryptophan biosynthesis|Fat digestion and absorption" GP1BB 23.22122838 16.64662212 29.79583464 1.789902745 0.8398812 0.304457087 1 0.926381259 1.630385759 2812 glycoprotein Ib platelet subunit beta "GO:0004888,GO:0005515,GO:0005886,GO:0005887,GO:0007155,GO:0007166,GO:0007596,GO:0007597,GO:0030168,GO:0042802" "transmembrane signaling receptor activity|protein binding|plasma membrane|integral component of plasma membrane|cell adhesion|cell surface receptor signaling pathway|blood coagulation|blood coagulation, intrinsic pathway|platelet activation|identical protein binding" "hsa04512,hsa04611,hsa04640" ECM-receptor interaction|Platelet activation|Hematopoietic cell lineage GPAA1 1582.454808 1511.721371 1653.188244 1.093579991 0.129058752 0.589025219 1 39.27837934 42.23527189 8733 glycosylphosphatidylinositol anchor attachment 1 "GO:0003923,GO:0005515,GO:0005739,GO:0005783,GO:0005789,GO:0005813,GO:0005829,GO:0006508,GO:0006621,GO:0015631,GO:0016020,GO:0016255,GO:0034235,GO:0042765,GO:0065003" GPI-anchor transamidase activity|protein binding|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|centrosome|cytosol|proteolysis|protein retention in ER lumen|tubulin binding|membrane|attachment of GPI anchor to protein|GPI anchor binding|GPI-anchor transamidase complex|protein-containing complex assembly hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis GPALPP1 836.6020867 805.2803452 867.9238283 1.0777909 0.108077311 0.668990495 1 9.206583543 9.756727815 55425 GPALPP motifs containing 1 GPAM 247.1693374 218.4869154 275.8517594 1.262555055 0.336346299 0.31929908 1 1.741114695 2.161468369 57678 "glycerol-3-phosphate acyltransferase, mitochondrial" "GO:0001817,GO:0004366,GO:0005515,GO:0005741,GO:0005886,GO:0006072,GO:0006631,GO:0006637,GO:0006651,GO:0006654,GO:0006655,GO:0008654,GO:0009749,GO:0016021,GO:0016024,GO:0019432,GO:0031966,GO:0033146,GO:0040018,GO:0042104,GO:0045540,GO:0051607,GO:0055089,GO:0055091,GO:0070236,GO:0102420" regulation of cytokine production|glycerol-3-phosphate O-acyltransferase activity|protein binding|mitochondrial outer membrane|plasma membrane|glycerol-3-phosphate metabolic process|fatty acid metabolic process|acyl-CoA metabolic process|diacylglycerol biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylglycerol biosynthetic process|phospholipid biosynthetic process|response to glucose|integral component of membrane|CDP-diacylglycerol biosynthetic process|triglyceride biosynthetic process|mitochondrial membrane|regulation of intracellular estrogen receptor signaling pathway|positive regulation of multicellular organism growth|positive regulation of activated T cell proliferation|regulation of cholesterol biosynthetic process|defense response to virus|fatty acid homeostasis|phospholipid homeostasis|negative regulation of activation-induced cell death of T cells|sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity "hsa00561,hsa00564" Glycerolipid metabolism|Glycerophospholipid metabolism GPANK1 264.4550533 255.9418151 272.9682915 1.066524793 0.092917504 0.787236953 1 4.801105192 5.034813129 7918 G-patch domain and ankyrin repeats 1 "GO:0003676,GO:0005515" nucleic acid binding|protein binding GPAT3 546.1763153 498.3582498 593.9943808 1.191902374 0.253266072 0.345918971 1 5.051560085 5.920213736 84803 glycerol-3-phosphate acyltransferase 3 "GO:0003841,GO:0004366,GO:0005783,GO:0005789,GO:0006072,GO:0006654,GO:0016021,GO:0016024,GO:0019432,GO:0032006,GO:0102420" 1-acylglycerol-3-phosphate O-acyltransferase activity|glycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|glycerol-3-phosphate metabolic process|phosphatidic acid biosynthetic process|integral component of membrane|CDP-diacylglycerol biosynthetic process|triglyceride biosynthetic process|regulation of TOR signaling|sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity "hsa00561,hsa00564" Glycerolipid metabolism|Glycerophospholipid metabolism GPAT4 1659.306427 1712.521251 1606.091602 0.937852071 -0.092567712 0.698533495 1 14.31163665 13.19759577 137964 glycerol-3-phosphate acyltransferase 4 "GO:0002071,GO:0003841,GO:0004366,GO:0005783,GO:0005789,GO:0006631,GO:0006637,GO:0006654,GO:0006656,GO:0007595,GO:0008610,GO:0016020,GO:0016021,GO:0016024,GO:0019432,GO:0040014,GO:0046339,GO:0102420" glandular epithelial cell maturation|1-acylglycerol-3-phosphate O-acyltransferase activity|glycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|fatty acid metabolic process|acyl-CoA metabolic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|lactation|lipid biosynthetic process|membrane|integral component of membrane|CDP-diacylglycerol biosynthetic process|triglyceride biosynthetic process|regulation of multicellular organism growth|diacylglycerol metabolic process|sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity "hsa00561,hsa00564" Glycerolipid metabolism|Glycerophospholipid metabolism GPATCH1 153.0854941 145.6579436 160.5130447 1.101986206 0.140106166 0.740416825 1 2.426185 2.628882954 55094 G-patch domain containing 1 "GO:0000398,GO:0003723,GO:0005634,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|nucleus|catalytic step 2 spliceosome" GPATCH11 544.5710351 506.6815608 582.4605093 1.149559318 0.201080911 0.455633771 1 6.882327224 7.779252749 253635 G-patch domain containing 11 "GO:0000776,GO:0000777,GO:0003676,GO:0005515" kinetochore|condensed chromosome kinetochore|nucleic acid binding|protein binding GPATCH2 369.3739236 373.5085839 365.2392633 0.977860427 -0.032299535 0.922589401 1 1.943022384 1.868210693 55105 G-patch domain containing 2 "GO:0003676,GO:0005730,GO:0010923,GO:0016607" nucleic acid binding|nucleolus|negative regulation of phosphatase activity|nuclear speck GPATCH2L 2087.344848 2200.475362 1974.214334 0.897176296 -0.156536592 0.508655177 1 6.605654503 5.827265746 55668 G-patch domain containing 2 like GO:0005515 protein binding GPATCH3 154.4379093 168.547049 140.3287696 0.832579214 -0.264340554 0.516580274 1 4.232962931 3.465302948 63906 G-patch domain containing 3 "GO:0003676,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0032480,GO:0039536,GO:0045893" "nucleic acid binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|negative regulation of type I interferon production|negative regulation of RIG-I signaling pathway|positive regulation of transcription, DNA-templated" GPATCH4 276.5928057 347.4982368 205.6873746 0.591909117 -0.756552416 0.019558418 0.80560651 8.609722481 5.010895676 54865 G-patch domain containing 4 "GO:0003723,GO:0005515" RNA binding|protein binding GPATCH8 1724.371309 1944.533547 1504.209071 0.773557789 -0.370419022 0.118627133 1 13.99543918 10.64511783 23131 G-patch domain containing 8 "GO:0003723,GO:0005515,GO:0005575,GO:0005634,GO:0008150,GO:0046872" RNA binding|protein binding|cellular_component|nucleus|biological_process|metal ion binding GPBP1 2115.38879 1876.906644 2353.870936 1.254122544 0.326678325 0.167217811 1 21.80863444 26.89302319 65056 GC-rich promoter binding protein 1 "GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0006351,GO:0006355,GO:0043231,GO:0045893" "DNA binding|RNA binding|protein binding|nucleus|cytosol|plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|intracellular membrane-bounded organelle|positive regulation of transcription, DNA-templated" GPBP1L1 1777.300282 1782.228981 1772.371583 0.994469062 -0.008001606 0.975726675 1 24.52031068 23.97664559 60313 GC-rich promoter binding protein 1 like 1 "GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0006351,GO:0006355,GO:0045893" "DNA binding|RNA binding|protein binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated" GPC1 1009.20258 1021.686433 996.7187264 0.975562261 -0.035694145 0.888431259 1 13.60756854 13.05289068 2817 glypican 1 "GO:0001523,GO:0005507,GO:0005576,GO:0005615,GO:0005654,GO:0005768,GO:0005796,GO:0005829,GO:0005886,GO:0006024,GO:0006027,GO:0007411,GO:0009986,GO:0014037,GO:0016477,GO:0017134,GO:0030200,GO:0031012,GO:0031226,GO:0032288,GO:0040037,GO:0043202,GO:0043236,GO:0045121,GO:0045202,GO:0046658,GO:0050900,GO:0062023,GO:0070062,GO:1905475,GO:2001016" retinoid metabolic process|copper ion binding|extracellular region|extracellular space|nucleoplasm|endosome|Golgi lumen|cytosol|plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|axon guidance|cell surface|Schwann cell differentiation|cell migration|fibroblast growth factor binding|heparan sulfate proteoglycan catabolic process|extracellular matrix|intrinsic component of plasma membrane|myelin assembly|negative regulation of fibroblast growth factor receptor signaling pathway|lysosomal lumen|laminin binding|membrane raft|synapse|anchored component of plasma membrane|leukocyte migration|collagen-containing extracellular matrix|extracellular exosome|regulation of protein localization to membrane|positive regulation of skeletal muscle cell differentiation "hsa05205,hsa05418" Proteoglycans in cancer|Fluid shear stress and atherosclerosis GPC2 39.63510714 31.21241648 48.0577978 1.539701286 0.622650484 0.348562487 1 0.654261312 0.990510062 221914 glypican 2 "GO:0001523,GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0005796,GO:0005886,GO:0006024,GO:0006027,GO:0007224,GO:0009966,GO:0009986,GO:0010976,GO:0016477,GO:0030182,GO:0043202,GO:0045202,GO:0046658,GO:0062023,GO:1905475" retinoid metabolic process|protein binding|extracellular region|extracellular space|endoplasmic reticulum|Golgi lumen|plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|smoothened signaling pathway|regulation of signal transduction|cell surface|positive regulation of neuron projection development|cell migration|neuron differentiation|lysosomal lumen|synapse|anchored component of plasma membrane|collagen-containing extracellular matrix|regulation of protein localization to membrane GPC5 34.30912042 30.1720026 38.44623824 1.274235547 0.34963199 0.637753836 1 0.167784133 0.210218912 2262 glypican 5 "GO:0001523,GO:0005515,GO:0005576,GO:0005615,GO:0005796,GO:0005886,GO:0006024,GO:0006027,GO:0009986,GO:0016021,GO:0016477,GO:0043202,GO:0046658,GO:0062023,GO:0090263,GO:1905475" retinoid metabolic process|protein binding|extracellular region|extracellular space|Golgi lumen|plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|cell surface|integral component of membrane|cell migration|lysosomal lumen|anchored component of plasma membrane|collagen-containing extracellular matrix|positive regulation of canonical Wnt signaling pathway|regulation of protein localization to membrane GPCPD1 583.6211542 598.2379825 569.0043259 0.951133734 -0.07227989 0.790000022 1 4.752435489 4.444562256 56261 glycerophosphocholine phosphodiesterase 1 "GO:0005829,GO:0007519,GO:0046475,GO:0047389,GO:2001070" cytosol|skeletal muscle tissue development|glycerophospholipid catabolic process|glycerophosphocholine phosphodiesterase activity|starch binding "hsa00564,hsa05231" Glycerophospholipid metabolism|Choline metabolism in cancer GPD1L 563.8432296 583.6721882 544.0142711 0.932054468 -0.101513828 0.707690683 1 7.879967604 7.221657768 23171 glycerol-3-phosphate dehydrogenase 1 like "GO:0002027,GO:0004367,GO:0005829,GO:0005886,GO:0005975,GO:0006116,GO:0006654,GO:0009331,GO:0010765,GO:0017080,GO:0019674,GO:0033137,GO:0042803,GO:0044325,GO:0046168,GO:0051287,GO:0060373,GO:0070062,GO:0086005,GO:0090038,GO:2000010,GO:2000649" regulation of heart rate|glycerol-3-phosphate dehydrogenase [NAD+] activity|cytosol|plasma membrane|carbohydrate metabolic process|NADH oxidation|phosphatidic acid biosynthetic process|glycerol-3-phosphate dehydrogenase complex|positive regulation of sodium ion transport|sodium channel regulator activity|NAD metabolic process|negative regulation of peptidyl-serine phosphorylation|protein homodimerization activity|ion channel binding|glycerol-3-phosphate catabolic process|NAD binding|regulation of ventricular cardiac muscle cell membrane depolarization|extracellular exosome|ventricular cardiac muscle cell action potential|negative regulation of protein kinase C signaling|positive regulation of protein localization to cell surface|regulation of sodium ion transmembrane transporter activity hsa00564 Glycerophospholipid metabolism GPD2 1344.436574 1243.29459 1445.578558 1.16269995 0.217478839 0.36561372 1 10.4855163 11.98750089 2820 glycerol-3-phosphate dehydrogenase 2 "GO:0004368,GO:0005509,GO:0005739,GO:0005743,GO:0006072,GO:0006127,GO:0009331,GO:0019563,GO:0052591" glycerol-3-phosphate dehydrogenase (quinone) activity|calcium ion binding|mitochondrion|mitochondrial inner membrane|glycerol-3-phosphate metabolic process|glycerophosphate shuttle|glycerol-3-phosphate dehydrogenase complex|glycerol catabolic process|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity hsa00564 Glycerophospholipid metabolism GPHN 564.4181568 548.2981162 580.5381974 1.058800277 0.082430478 0.762164867 1 6.746982414 7.024166591 10243 gephyrin "GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006777,GO:0007529,GO:0008940,GO:0010038,GO:0014069,GO:0018315,GO:0030425,GO:0032324,GO:0042802,GO:0043546,GO:0045211,GO:0046872,GO:0055114,GO:0061598,GO:0061599,GO:0072579,GO:0097060,GO:0097112,GO:0098970,GO:0099144,GO:0099572,GO:0099634" protein binding|ATP binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|Mo-molybdopterin cofactor biosynthetic process|establishment of synaptic specificity at neuromuscular junction|nitrate reductase activity|response to metal ion|postsynaptic density|molybdenum incorporation into molybdenum-molybdopterin complex|dendrite|molybdopterin cofactor biosynthetic process|identical protein binding|molybdopterin cofactor binding|postsynaptic membrane|metal ion binding|oxidation-reduction process|molybdopterin adenylyltransferase activity|molybdopterin molybdotransferase activity|glycine receptor clustering|synaptic membrane|gamma-aminobutyric acid receptor clustering|postsynaptic neurotransmitter receptor diffusion trapping|anchored component of synaptic membrane|postsynaptic specialization|postsynaptic specialization membrane "hsa00790,hsa04727" Folate biosynthesis|GABAergic synapse GPI 4626.646231 4368.697893 4884.594568 1.118089346 0.161035477 0.501181225 1 21.16077121 23.26372092 2821 glucose-6-phosphate isomerase "GO:0002639,GO:0004347,GO:0005125,GO:0005515,GO:0005576,GO:0005654,GO:0005829,GO:0005886,GO:0005975,GO:0006094,GO:0006096,GO:0006959,GO:0007165,GO:0007599,GO:0008083,GO:0010595,GO:0016020,GO:0031625,GO:0034774,GO:0043312,GO:0048029,GO:0051156,GO:0061621,GO:0070062,GO:1904813" positive regulation of immunoglobulin production|glucose-6-phosphate isomerase activity|cytokine activity|protein binding|extracellular region|nucleoplasm|cytosol|plasma membrane|carbohydrate metabolic process|gluconeogenesis|glycolytic process|humoral immune response|signal transduction|hemostasis|growth factor activity|positive regulation of endothelial cell migration|membrane|ubiquitin protein ligase binding|secretory granule lumen|neutrophil degranulation|monosaccharide binding|glucose 6-phosphate metabolic process|canonical glycolysis|extracellular exosome|ficolin-1-rich granule lumen "hsa00010,hsa00030,hsa00500,hsa00520" Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism GPKOW 786.0728163 677.3094376 894.836195 1.321163039 0.401808514 0.111110076 1 20.2050083 26.24742038 27238 G-patch domain and KOW motifs "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex" GPLD1 5.04355356 6.242483296 3.844623824 0.615880514 -0.699277611 0.760739355 1 0.042069688 0.025476334 2822 glycosylphosphatidylinositol specific phospholipase D1 "GO:0001503,GO:0002042,GO:0002062,GO:0002430,GO:0004621,GO:0004630,GO:0005576,GO:0005615,GO:0005737,GO:0005765,GO:0006501,GO:0006507,GO:0008285,GO:0008286,GO:0009749,GO:0010595,GO:0010694,GO:0010867,GO:0010897,GO:0010907,GO:0010983,GO:0017080,GO:0031012,GO:0032869,GO:0035690,GO:0035701,GO:0035774,GO:0043065,GO:0043231,GO:0046470,GO:0051044,GO:0051047,GO:0070062,GO:0070633,GO:0071277,GO:0071397,GO:0071401,GO:0071467,GO:0097241,GO:1900076" ossification|cell migration involved in sprouting angiogenesis|chondrocyte differentiation|complement receptor mediated signaling pathway|glycosylphosphatidylinositol phospholipase D activity|phospholipase D activity|extracellular region|extracellular space|cytoplasm|lysosomal membrane|C-terminal protein lipidation|GPI anchor release|negative regulation of cell population proliferation|insulin receptor signaling pathway|response to glucose|positive regulation of endothelial cell migration|positive regulation of alkaline phosphatase activity|positive regulation of triglyceride biosynthetic process|negative regulation of triglyceride catabolic process|positive regulation of glucose metabolic process|positive regulation of high-density lipoprotein particle clearance|sodium channel regulator activity|extracellular matrix|cellular response to insulin stimulus|cellular response to drug|hematopoietic stem cell migration|positive regulation of insulin secretion involved in cellular response to glucose stimulus|positive regulation of apoptotic process|intracellular membrane-bounded organelle|phosphatidylcholine metabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of secretion|extracellular exosome|transepithelial transport|cellular response to calcium ion|cellular response to cholesterol|cellular response to triglyceride|cellular response to pH|hematopoietic stem cell migration to bone marrow|regulation of cellular response to insulin stimulus hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis GPM6A 44.59437235 47.8590386 41.32970611 0.863571591 -0.211612311 0.763235008 1 0.72417038 0.614908197 2823 glycoprotein M6A "GO:0001764,GO:0003407,GO:0005262,GO:0005515,GO:0005886,GO:0007416,GO:0009617,GO:0030175,GO:0031175,GO:0043005,GO:0043025,GO:0043197,GO:0044295,GO:0048812,GO:0048863,GO:0050807,GO:0051491,GO:0070062,GO:0070588,GO:0098978,GO:0099059,GO:1903561" neuron migration|neural retina development|calcium channel activity|protein binding|plasma membrane|synapse assembly|response to bacterium|filopodium|neuron projection development|neuron projection|neuronal cell body|dendritic spine|axonal growth cone|neuron projection morphogenesis|stem cell differentiation|regulation of synapse organization|positive regulation of filopodium assembly|extracellular exosome|calcium ion transmembrane transport|glutamatergic synapse|integral component of presynaptic active zone membrane|extracellular vesicle GPN1 950.0575041 907.2409057 992.8741025 1.094388598 0.130125104 0.600576687 1 16.2421267 17.47775439 11321 GPN-loop GTPase 1 "GO:0003924,GO:0005515,GO:0005525,GO:0005654,GO:0005739,GO:0005829" GTPase activity|protein binding|GTP binding|nucleoplasm|mitochondrion|cytosol GPN2 621.3043813 603.4400519 639.1687107 1.059208299 0.08298633 0.7556769 1 6.903426902 7.18980785 54707 GPN-loop GTPase 2 "GO:0003674,GO:0003924,GO:0005515,GO:0005525,GO:0005575,GO:0008150" molecular_function|GTPase activity|protein binding|GTP binding|cellular_component|biological_process GPN3 752.0260074 691.875232 812.1767828 1.173877522 0.231281891 0.362862302 1 21.23295544 24.50780486 51184 GPN-loop GTPase 3 "GO:0003924,GO:0005515,GO:0005525,GO:0032991" GTPase activity|protein binding|GTP binding|protein-containing complex GPNMB 14.84822752 23.9295193 5.766935736 0.240996723 -2.052914565 0.039696008 1 0.457404894 0.108388479 10457 glycoprotein nmb "GO:0001818,GO:0001934,GO:0005178,GO:0005515,GO:0005886,GO:0005887,GO:0007155,GO:0007165,GO:0007267,GO:0008201,GO:0008285,GO:0016021,GO:0030335,GO:0031901,GO:0031954,GO:0033162,GO:0034103,GO:0042056,GO:0042130,GO:0045545,GO:0045765,GO:0048018,GO:0050868,GO:0050918,GO:0070374,GO:1901215,GO:2000134" negative regulation of cytokine production|positive regulation of protein phosphorylation|integrin binding|protein binding|plasma membrane|integral component of plasma membrane|cell adhesion|signal transduction|cell-cell signaling|heparin binding|negative regulation of cell population proliferation|integral component of membrane|positive regulation of cell migration|early endosome membrane|positive regulation of protein autophosphorylation|melanosome membrane|regulation of tissue remodeling|chemoattractant activity|negative regulation of T cell proliferation|syndecan binding|regulation of angiogenesis|receptor ligand activity|negative regulation of T cell activation|positive chemotaxis|positive regulation of ERK1 and ERK2 cascade|negative regulation of neuron death|negative regulation of G1/S transition of mitotic cell cycle GPR1 27.30362598 22.88910542 31.71814655 1.385731158 0.470647391 0.55518026 1 0.485512515 0.661531593 2825 G protein-coupled receptor 1 "GO:0004930,GO:0005515,GO:0005654,GO:0005886,GO:0005887,GO:0007186,GO:0007218,GO:0042277,GO:0042923,GO:0043005,GO:0043231" G protein-coupled receptor activity|protein binding|nucleoplasm|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|peptide binding|neuropeptide binding|neuron projection|intracellular membrane-bounded organelle GPR107 3492.100275 3626.882795 3357.317754 0.925675834 -0.111421037 0.639289927 1 28.1460039 25.61809595 57720 G protein-coupled receptor 107 "GO:0005654,GO:0005769,GO:0005794,GO:0005886,GO:0006810,GO:0016020,GO:0016021,GO:0030136,GO:0032050,GO:0072583" nucleoplasm|early endosome|Golgi apparatus|plasma membrane|transport|membrane|integral component of membrane|clathrin-coated vesicle|clathrin heavy chain binding|clathrin-dependent endocytosis GPR108 828.6549436 848.9777282 808.332159 0.952124104 -0.070778462 0.781537702 1 18.01526084 16.86573581 56927 G protein-coupled receptor 108 "GO:0005515,GO:0005794,GO:0006810,GO:0016020,GO:0016021" protein binding|Golgi apparatus|transport|membrane|integral component of membrane GPR132 4.885037707 2.080827765 7.689247648 3.695283087 1.88568489 0.299624042 1 0.029660778 0.107770881 29933 G protein-coupled receptor 132 "GO:0000082,GO:0004930,GO:0005886,GO:0007186,GO:0010972,GO:0016021" G1/S transition of mitotic cell cycle|G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|negative regulation of G2/M transition of mitotic cell cycle|integral component of membrane GPR135 115.5708437 119.6475965 111.4940909 0.931853996 -0.101824166 0.836695201 1 0.722082135 0.661615469 64582 G protein-coupled receptor 135 "GO:0004930,GO:0005515,GO:0005768,GO:0005886,GO:0007186,GO:0010008,GO:0016021,GO:1990763" G protein-coupled receptor activity|protein binding|endosome|plasma membrane|G protein-coupled receptor signaling pathway|endosome membrane|integral component of membrane|arrestin family protein binding GPR137 497.8511756 466.1054194 529.5969318 1.136217065 0.184238477 0.503662686 1 8.217769927 9.180925527 56834 G protein-coupled receptor 137 "GO:0005765,GO:0006914,GO:0010506,GO:0016021,GO:0045671,GO:0045779,GO:1904263" lysosomal membrane|autophagy|regulation of autophagy|integral component of membrane|negative regulation of osteoclast differentiation|negative regulation of bone resorption|positive regulation of TORC1 signaling GPR137B 607.4959533 682.511507 532.4803996 0.780177908 -0.358124948 0.172164745 1 4.800261561 3.682389548 7107 G protein-coupled receptor 137B "GO:0005515,GO:0005765,GO:0005887,GO:0006914,GO:0010506,GO:0016020,GO:0043030,GO:0043087,GO:0045671,GO:0045779,GO:0150032,GO:1904263" protein binding|lysosomal membrane|integral component of plasma membrane|autophagy|regulation of autophagy|membrane|regulation of macrophage activation|regulation of GTPase activity|negative regulation of osteoclast differentiation|negative regulation of bone resorption|positive regulation of protein localization to lysosome|positive regulation of TORC1 signaling GPR137C 173.3093981 146.6983575 199.9204388 1.362799436 0.446573256 0.246289498 1 1.487841451 1.993699858 283554 G protein-coupled receptor 137C "GO:0005765,GO:0016021,GO:1904263" lysosomal membrane|integral component of membrane|positive regulation of TORC1 signaling GPR146 9.086322201 11.44455271 6.728091692 0.587885946 -0.766391806 0.566347083 1 0.252804116 0.146133033 115330 G protein-coupled receptor 146 "GO:0004930,GO:0005886,GO:0007186,GO:0016021" G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane GPR153 196.2827919 182.0724295 210.4931544 1.156095709 0.209260838 0.574821739 1 2.158345385 2.453499144 387509 G protein-coupled receptor 153 "GO:0004930,GO:0005886,GO:0007186,GO:0016021" G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane GPR155 215.9764282 207.0423626 224.9104937 1.086301812 0.119424989 0.745515224 1 1.405069986 1.500789005 151556 G protein-coupled receptor 155 "GO:0003674,GO:0016021,GO:0035556,GO:0050890,GO:0055085,GO:0070062" molecular_function|integral component of membrane|intracellular signal transduction|cognition|transmembrane transport|extracellular exosome GPR156 22.09652615 24.96993318 19.22311912 0.769850643 -0.377349516 0.680227645 1 0.255287249 0.193244339 165829 G protein-coupled receptor 156 "GO:0004888,GO:0004965,GO:0005886,GO:0007214,GO:0038039" transmembrane signaling receptor activity|G protein-coupled GABA receptor activity|plasma membrane|gamma-aminobutyric acid signaling pathway|G protein-coupled receptor heterodimeric complex hsa04080 Neuroactive ligand-receptor interaction GPR157 116.6609474 97.79890497 135.5229898 1.385731158 0.470647391 0.291202413 1 1.007596103 1.372892838 80045 G protein-coupled receptor 157 "GO:0004930,GO:0007166,GO:0007186,GO:0016021,GO:0048512,GO:0051482,GO:0060019,GO:0060170" G protein-coupled receptor activity|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|integral component of membrane|circadian behavior|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|radial glial cell differentiation|ciliary membrane GPR158 102.8430729 100.9201466 104.7659992 1.038107878 0.053956373 0.929524198 1 0.739722942 0.755062242 57512 G protein-coupled receptor 158 "GO:0004930,GO:0005886,GO:0007186,GO:0016021,GO:0072659" G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|protein localization to plasma membrane GPR160 186.6712324 182.0724295 191.2700352 1.050516192 0.071098399 0.862749285 1 2.979721228 3.07786498 26996 G protein-coupled receptor 160 "GO:0004930,GO:0005515,GO:0005886,GO:0007186,GO:0016021,GO:0043235" G protein-coupled receptor activity|protein binding|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|receptor complex GPR161 1086.956218 1170.465618 1003.446818 0.857305676 -0.222118399 0.363328617 1 6.542955777 5.515448868 23432 G protein-coupled receptor 161 "GO:0004930,GO:0005515,GO:0005929,GO:0007186,GO:0007189,GO:0007275,GO:0016021,GO:0030666,GO:0055037,GO:0060170,GO:1901621" G protein-coupled receptor activity|protein binding|cilium|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|multicellular organism development|integral component of membrane|endocytic vesicle membrane|recycling endosome|ciliary membrane|negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning hsa04340 Hedgehog signaling pathway GPR162 62.81167614 59.30359131 66.31976096 1.118309355 0.161319333 0.794682523 1 2.11984171 2.330969386 27239 G protein-coupled receptor 162 "GO:0004930,GO:0005515,GO:0005886,GO:0007186,GO:0016021" G protein-coupled receptor activity|protein binding|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane GPR173 474.4022343 418.2463808 530.5580877 1.268530015 0.343157656 0.215411539 1 4.495677873 5.607471972 54328 G protein-coupled receptor 173 "GO:0004930,GO:0004968,GO:0005886,GO:0007165,GO:0007186,GO:0016021,GO:0097211" G protein-coupled receptor activity|gonadotropin-releasing hormone receptor activity|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|integral component of membrane|cellular response to gonadotropin-releasing hormone GPR174 9.408384325 7.282897178 11.53387147 1.583692752 0.663292469 0.627344635 1 0.070745329 0.110164046 84636 G protein-coupled receptor 174 "GO:0004930,GO:0005887,GO:0035025,GO:0043029,GO:0045125,GO:0051482" G protein-coupled receptor activity|integral component of plasma membrane|positive regulation of Rho protein signal transduction|T cell homeostasis|bioactive lipid receptor activity|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GPR176 2357.205146 2459.538419 2254.871873 0.916786603 -0.125342132 0.596679852 1 14.40529466 12.98558691 11245 G protein-coupled receptor 176 "GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0007193,GO:0007268,GO:0045202,GO:0048512" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|chemical synaptic transmission|synapse|circadian behavior GPR180 1006.735523 982.1507052 1031.320341 1.050063229 0.070476201 0.777509872 1 5.899997526 6.091699318 160897 G protein-coupled receptor 180 "GO:0007186,GO:0016021,GO:0019236" G protein-coupled receptor signaling pathway|integral component of membrane|response to pheromone GPR19 98.15618002 104.0413883 92.27097178 0.886867941 -0.173208799 0.729052642 1 0.799726008 0.697382997 2842 G protein-coupled receptor 19 "GO:0004930,GO:0005887,GO:0005929,GO:0007186" G protein-coupled receptor activity|integral component of plasma membrane|cilium|G protein-coupled receptor signaling pathway GPR3 138.0290609 141.496288 134.5618338 0.950991971 -0.072494934 0.879314811 1 3.533643815 3.304234034 2827 G protein-coupled receptor 3 "GO:0004930,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0007189,GO:0019222,GO:0040020,GO:0120162" G protein-coupled receptor activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|adenylate cyclase-activating G protein-coupled receptor signaling pathway|regulation of metabolic process|regulation of meiotic nuclear division|positive regulation of cold-induced thermogenesis GPR35 8.967435311 8.323311061 9.61155956 1.154775965 0.207612985 0.965671908 1 0.190398549 0.21618848 2859 G protein-coupled receptor 35 "GO:0004930,GO:0005886,GO:0005887,GO:0007010,GO:0007186,GO:0007204,GO:0016494,GO:0035025,GO:0051482,GO:0070098,GO:1901386,GO:1904456" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|cytoskeleton organization|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|C-X-C chemokine receptor activity|positive regulation of Rho protein signal transduction|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|chemokine-mediated signaling pathway|negative regulation of voltage-gated calcium channel activity|negative regulation of neuronal action potential hsa04080 Neuroactive ligand-receptor interaction GPR39 275.6914004 298.5987843 252.7840164 0.846567467 -0.240303047 0.462415305 1 6.186206645 5.149406495 2863 G protein-coupled receptor 39 "GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0007186,GO:0046872" G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|metal ion binding GPR4 5.524131538 6.242483296 4.80577978 0.769850643 -0.377349516 0.927604977 1 0.076533393 0.057933348 2828 G protein-coupled receptor 4 "GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0007189,GO:0007200,GO:0010447,GO:0016525,GO:0030155,GO:0035025,GO:0043114,GO:0050729,GO:0051482,GO:0060055,GO:0072144" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|response to acidic pH|negative regulation of angiogenesis|regulation of cell adhesion|positive regulation of Rho protein signal transduction|regulation of vascular permeability|positive regulation of inflammatory response|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|angiogenesis involved in wound healing|glomerular mesangial cell development GPR45 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.096565177 0.087716126 11250 G protein-coupled receptor 45 "GO:0004930,GO:0005515,GO:0005886,GO:0007186,GO:0016021" G protein-coupled receptor activity|protein binding|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane GPR55 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.035646251 0.032379696 9290 G protein-coupled receptor 55 "GO:0004930,GO:0004949,GO:0005886,GO:0005887,GO:0007186,GO:0007202,GO:0035025,GO:0038171,GO:0045453,GO:0045671,GO:0051482,GO:0070374" G protein-coupled receptor activity|cannabinoid receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|activation of phospholipase C activity|positive regulation of Rho protein signal transduction|cannabinoid signaling pathway|bone resorption|negative regulation of osteoclast differentiation|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|positive regulation of ERK1 and ERK2 cascade GPR63 172.2884916 195.5978099 148.9791732 0.761660743 -0.392779556 0.309327419 1 1.430742273 1.071504895 81491 G protein-coupled receptor 63 "GO:0003674,GO:0004930,GO:0005654,GO:0005829,GO:0005886,GO:0007186,GO:0008150,GO:0016021,GO:0043235" molecular_function|G protein-coupled receptor activity|nucleoplasm|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|biological_process|integral component of membrane|receptor complex GPR65 43.16269926 22.88910542 63.4362931 2.771462315 1.470647391 0.022163366 0.822216713 0.270793502 0.737935486 8477 G protein-coupled receptor 65 "GO:0004930,GO:0005886,GO:0005887,GO:0006915,GO:0006955,GO:0007186,GO:0007189,GO:0007275,GO:0010447,GO:0031532,GO:0035025,GO:0051482,GO:0051496,GO:0090630" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|apoptotic process|immune response|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|multicellular organism development|response to acidic pH|actin cytoskeleton reorganization|positive regulation of Rho protein signal transduction|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|positive regulation of stress fiber assembly|activation of GTPase activity GPR68 28.0616067 30.1720026 25.95121081 0.860108994 -0.217408603 0.811456852 1 0.262080782 0.221645972 8111 G protein-coupled receptor 68 "GO:0004930,GO:0005886,GO:0005887,GO:0006954,GO:0007186,GO:0035774,GO:0045656,GO:0071467,GO:2001206" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|inflammatory response|G protein-coupled receptor signaling pathway|positive regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of monocyte differentiation|cellular response to pH|positive regulation of osteoclast development GPR75 15.57160969 17.687036 13.45618338 0.760793577 -0.394423029 0.724394511 1 0.450775838 0.337208602 10936 G protein-coupled receptor 75 "GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0016493,GO:0070098,GO:1901214" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|C-C chemokine receptor activity|chemokine-mediated signaling pathway|regulation of neuron death GPR85 89.79827041 73.86938567 105.7271552 1.431271618 0.517297484 0.290291626 1 0.984337914 1.38527964 54329 G protein-coupled receptor 85 "GO:0004930,GO:0005515,GO:0005783,GO:0005886,GO:0007165,GO:0007186,GO:0016021" G protein-coupled receptor activity|protein binding|endoplasmic reticulum|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|integral component of membrane GPR87 2.601034707 5.202069413 0 0 #NAME? 0.147074026 1 0.185951027 0 53836 G protein-coupled receptor 87 "GO:0005886,GO:0007186,GO:0007194,GO:0008150,GO:0016021,GO:0035589,GO:0045028" plasma membrane|G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|biological_process|integral component of membrane|G protein-coupled purinergic nucleotide receptor signaling pathway|G protein-coupled purinergic nucleotide receptor activity GPR89A 258.02007 124.8496659 391.1904741 3.133292117 1.647679279 1.35E-06 0.000971402 2.188895271 6.743681456 653519 G protein-coupled receptor 89A "GO:0008308,GO:0015031,GO:0015698,GO:0016021,GO:0030217,GO:0030660,GO:0032580,GO:0034220,GO:0034765,GO:0043123,GO:0051452" voltage-gated anion channel activity|protein transport|inorganic anion transport|integral component of membrane|T cell differentiation|Golgi-associated vesicle membrane|Golgi cisterna membrane|ion transmembrane transport|regulation of ion transmembrane transport|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular pH reduction GPR89B 64.12949276 68.66731625 59.59166927 0.867831634 -0.204512919 0.729838263 1 1.305074239 1.113632438 51463 G protein-coupled receptor 89B "GO:0005515,GO:0008308,GO:0015031,GO:0015698,GO:0016021,GO:0030217,GO:0032580,GO:0034220,GO:0034765,GO:0051452" protein binding|voltage-gated anion channel activity|protein transport|inorganic anion transport|integral component of membrane|T cell differentiation|Golgi cisterna membrane|ion transmembrane transport|regulation of ion transmembrane transport|intracellular pH reduction GPRASP1 51.15388736 68.66731625 33.64045846 0.489904955 -1.029426212 0.083614682 1 0.6210216 0.299150489 9737 G protein-coupled receptor associated sorting protein 1 "GO:0005515,GO:0005829,GO:0008333,GO:1990172" protein binding|cytosol|endosome to lysosome transport|G protein-coupled receptor catabolic process GPRC5A 4234.887089 4189.746705 4280.027472 1.021548025 0.03075703 0.89836295 1 33.97129767 34.12259911 9052 G protein-coupled receptor class C group 5 member A "GO:0004930,GO:0005515,GO:0005730,GO:0005886,GO:0005887,GO:0007165,GO:0007175,GO:0007186,GO:0030295,GO:0030659,GO:0031982,GO:0032147,GO:0043231,GO:0043235,GO:0045296,GO:0070062" G protein-coupled receptor activity|protein binding|nucleolus|plasma membrane|integral component of plasma membrane|signal transduction|negative regulation of epidermal growth factor-activated receptor activity|G protein-coupled receptor signaling pathway|protein kinase activator activity|cytoplasmic vesicle membrane|vesicle|activation of protein kinase activity|intracellular membrane-bounded organelle|receptor complex|cadherin binding|extracellular exosome GPRC5B 842.5351416 1188.152654 496.9176292 0.418227092 -1.257641575 7.00E-07 0.000563628 10.95912952 4.506707797 51704 G protein-coupled receptor class C group 5 member B "GO:0001664,GO:0004930,GO:0005615,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0007186,GO:0009986,GO:0016021,GO:0019901,GO:0030295,GO:0030659,GO:0032147,GO:0043123,GO:0043231,GO:0043235,GO:0045666,GO:0050729,GO:0060907,GO:0061098,GO:0070062,GO:0090263" G protein-coupled receptor binding|G protein-coupled receptor activity|extracellular space|nucleoplasm|nucleolus|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|cell surface|integral component of membrane|protein kinase binding|protein kinase activator activity|cytoplasmic vesicle membrane|activation of protein kinase activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|receptor complex|positive regulation of neuron differentiation|positive regulation of inflammatory response|positive regulation of macrophage cytokine production|positive regulation of protein tyrosine kinase activity|extracellular exosome|positive regulation of canonical Wnt signaling pathway GPRC5C 22.37392889 32.25283036 12.49502743 0.387408711 -1.368071702 0.095327078 1 0.318106501 0.121175021 55890 G protein-coupled receptor class C group 5 member C "GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0030295,GO:0030659,GO:0031982,GO:0032147,GO:0043231,GO:0043235,GO:0070062" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|protein kinase activator activity|cytoplasmic vesicle membrane|vesicle|activation of protein kinase activity|intracellular membrane-bounded organelle|receptor complex|extracellular exosome GPRIN1 733.8131196 768.8658593 698.76038 0.908819623 -0.13793411 0.590525502 1 9.691298487 8.660258268 114787 G protein regulated inducer of neurite outgrowth 1 "GO:0005886,GO:0030426,GO:0031175,GO:0051219" plasma membrane|growth cone|neuron projection development|phosphoprotein binding GPRIN3 72.1804315 65.54607461 78.81478839 1.202433385 0.265956971 0.628163451 1 0.211517326 0.250079534 285513 GPRIN family member 3 "GO:0005886,GO:0031175" plasma membrane|neuron projection development GPS1 1849.397039 1757.259048 1941.535031 1.104865577 0.143870855 0.544614776 1 44.17413362 47.98976927 2873 G protein pathway suppressor 1 "GO:0000188,GO:0000338,GO:0000715,GO:0005095,GO:0005515,GO:0005654,GO:0005829,GO:0006283,GO:0007254,GO:0008180,GO:0034260,GO:0043687" "inactivation of MAPK activity|protein deneddylation|nucleotide-excision repair, DNA damage recognition|GTPase inhibitor activity|protein binding|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|JNK cascade|COP9 signalosome|negative regulation of GTPase activity|post-translational protein modification" GPS2 635.007785 685.6327487 584.3828212 0.852326296 -0.230522251 0.376945283 1 31.11476161 26.07615442 2874 G protein pathway suppressor 2 "GO:0000122,GO:0000188,GO:0003713,GO:0003714,GO:0005095,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0007254,GO:0010804,GO:0010875,GO:0016032,GO:0017053,GO:0019216,GO:0030183,GO:0030332,GO:0034122,GO:0034260,GO:0035360,GO:0045598,GO:0045599,GO:0045944,GO:0046329,GO:0050728,GO:0050859,GO:0098780,GO:1900045" negative regulation of transcription by RNA polymerase II|inactivation of MAPK activity|transcription coactivator activity|transcription corepressor activity|GTPase inhibitor activity|protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|JNK cascade|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cholesterol efflux|viral process|transcription repressor complex|regulation of lipid metabolic process|B cell differentiation|cyclin binding|negative regulation of toll-like receptor signaling pathway|negative regulation of GTPase activity|positive regulation of peroxisome proliferator activated receptor signaling pathway|regulation of fat cell differentiation|negative regulation of fat cell differentiation|positive regulation of transcription by RNA polymerase II|negative regulation of JNK cascade|negative regulation of inflammatory response|negative regulation of B cell receptor signaling pathway|response to mitochondrial depolarisation|negative regulation of protein K63-linked ubiquitination hsa05166 Human T-cell leukemia virus 1 infection GPSM1 802.609998 783.4316536 821.7883424 1.04895984 0.068959445 0.788123805 1 8.858115989 9.136322112 26086 G protein signaling modulator 1 "GO:0000139,GO:0005092,GO:0005515,GO:0005789,GO:0005829,GO:0005886,GO:0005938,GO:0007399,GO:0016239,GO:0030154,GO:0032991,GO:0034260,GO:1905098" Golgi membrane|GDP-dissociation inhibitor activity|protein binding|endoplasmic reticulum membrane|cytosol|plasma membrane|cell cortex|nervous system development|positive regulation of macroautophagy|cell differentiation|protein-containing complex|negative regulation of GTPase activity|negative regulation of guanyl-nucleotide exchange factor activity hsa05030 Cocaine addiction GPSM2 1560.708683 1710.440423 1410.976943 0.824920251 -0.277673441 0.243812425 1 13.26017747 10.75554646 29899 G protein signaling modulator 2 "GO:0000132,GO:0000166,GO:0005092,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005938,GO:0007052,GO:0007186,GO:0008022,GO:0016328,GO:0019904,GO:0031291,GO:0032991,GO:0042802,GO:0043621,GO:0050790,GO:0051301,GO:0051661,GO:0060236,GO:0070840,GO:0097431,GO:0097575,GO:0099738,GO:1904778,GO:1905832" establishment of mitotic spindle orientation|nucleotide binding|GDP-dissociation inhibitor activity|protein binding|cytoplasm|centrosome|cytosol|cell cortex|mitotic spindle organization|G protein-coupled receptor signaling pathway|protein C-terminus binding|lateral plasma membrane|protein domain specific binding|Ran protein signal transduction|protein-containing complex|identical protein binding|protein self-association|regulation of catalytic activity|cell division|maintenance of centrosome location|regulation of mitotic spindle organization|dynein complex binding|mitotic spindle pole|lateral cell cortex|cell cortex region|positive regulation of protein localization to cell cortex|positive regulation of spindle assembly GPSM3 78.18514101 71.7885579 84.58172413 1.178206202 0.236592052 0.659049977 1 2.44182498 2.828831082 63940 G protein signaling modulator 3 "GO:0002690,GO:0003674,GO:0005515,GO:0005575,GO:0005737,GO:0005886,GO:0008150,GO:0030695,GO:0050729,GO:0050790,GO:1900017" positive regulation of leukocyte chemotaxis|molecular_function|protein binding|cellular_component|cytoplasm|plasma membrane|biological_process|GTPase regulator activity|positive regulation of inflammatory response|regulation of catalytic activity|positive regulation of cytokine production involved in inflammatory response GPT2 1097.260977 1239.132934 955.3890203 0.771014145 -0.375170766 0.123855179 1 14.64354457 11.10145078 84706 glutamic--pyruvic transaminase 2 "GO:0004021,GO:0005759,GO:0006103,GO:0008652,GO:0030170,GO:0042851,GO:0042853" L-alanine:2-oxoglutarate aminotransferase activity|mitochondrial matrix|2-oxoglutarate metabolic process|cellular amino acid biosynthetic process|pyridoxal phosphate binding|L-alanine metabolic process|L-alanine catabolic process "hsa00220,hsa00250" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism" GPX1 7479.354267 6463.051039 8495.657495 1.314496427 0.39451022 0.108366562 1 292.802339 378.4470551 2876 glutathione peroxidase 1 "GO:0001659,GO:0001885,GO:0002862,GO:0004601,GO:0004602,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006195,GO:0006641,GO:0006749,GO:0007605,GO:0009410,GO:0009609,GO:0009650,GO:0010269,GO:0010332,GO:0017124,GO:0018158,GO:0019369,GO:0019372,GO:0033194,GO:0033599,GO:0034599,GO:0040029,GO:0042311,GO:0042542,GO:0042744,GO:0043154,GO:0043403,GO:0043534,GO:0045444,GO:0045454,GO:0047066,GO:0048741,GO:0051450,GO:0051702,GO:0051897,GO:0060047,GO:0060055,GO:0061136,GO:0090201,GO:0097413,GO:0098869,GO:1902042,GO:1902176,GO:1902905" "temperature homeostasis|endothelial cell development|negative regulation of inflammatory response to antigenic stimulus|peroxidase activity|glutathione peroxidase activity|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|purine nucleotide catabolic process|triglyceride metabolic process|glutathione metabolic process|sensory perception of sound|response to xenobiotic stimulus|response to symbiotic bacterium|UV protection|response to selenium ion|response to gamma radiation|SH3 domain binding|protein oxidation|arachidonic acid metabolic process|lipoxygenase pathway|response to hydroperoxide|regulation of mammary gland epithelial cell proliferation|cellular response to oxidative stress|regulation of gene expression, epigenetic|vasodilation|response to hydrogen peroxide|hydrogen peroxide catabolic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|skeletal muscle tissue regeneration|blood vessel endothelial cell migration|fat cell differentiation|cell redox homeostasis|phospholipid-hydroperoxide glutathione peroxidase activity|skeletal muscle fiber development|myoblast proliferation|biological process involved in interaction with symbiont|positive regulation of protein kinase B signaling|heart contraction|angiogenesis involved in wound healing|regulation of proteasomal protein catabolic process|negative regulation of release of cytochrome c from mitochondria|Lewy body|cellular oxidant detoxification|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|positive regulation of supramolecular fiber organization" "hsa00480,hsa00590,hsa04918,hsa05014,hsa05016,hsa05022" Glutathione metabolism|Arachidonic acid metabolism|Thyroid hormone synthesis|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases GPX4 4373.333175 4190.787119 4555.879231 1.08711779 0.120508266 0.614216036 1 193.9762413 207.3463148 2879 glutathione peroxidase 4 "GO:0004601,GO:0004602,GO:0005515,GO:0005634,GO:0005739,GO:0005829,GO:0006644,GO:0006979,GO:0007275,GO:0007283,GO:0019369,GO:0019372,GO:0032991,GO:0042759,GO:0042802,GO:0047066,GO:0051258,GO:0055114,GO:0070062,GO:0098869,GO:0110076" peroxidase activity|glutathione peroxidase activity|protein binding|nucleus|mitochondrion|cytosol|phospholipid metabolic process|response to oxidative stress|multicellular organism development|spermatogenesis|arachidonic acid metabolic process|lipoxygenase pathway|protein-containing complex|long-chain fatty acid biosynthetic process|identical protein binding|phospholipid-hydroperoxide glutathione peroxidase activity|protein polymerization|oxidation-reduction process|extracellular exosome|cellular oxidant detoxification|negative regulation of ferroptosis "hsa00480,hsa04216" Glutathione metabolism|Ferroptosis GPX7 2.40288989 0 4.80577978 Inf Inf 0.18976424 1 0 0.205194355 2882 glutathione peroxidase 7 "GO:0004096,GO:0004601,GO:0004602,GO:0005515,GO:0005576,GO:0005783,GO:0005788,GO:0034599,GO:0055114,GO:0098869" catalase activity|peroxidase activity|glutathione peroxidase activity|protein binding|extracellular region|endoplasmic reticulum|endoplasmic reticulum lumen|cellular response to oxidative stress|oxidation-reduction process|cellular oxidant detoxification "hsa00480,hsa00590,hsa04918,hsa05014,hsa05016,hsa05022" Glutathione metabolism|Arachidonic acid metabolism|Thyroid hormone synthesis|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases GPX8 2268.012599 2174.465015 2361.560184 1.086041931 0.119079805 0.615329155 1 30.94592036 33.04617325 493869 glutathione peroxidase 8 (putative) "GO:0004601,GO:0004602,GO:0005515,GO:0005788,GO:0016021,GO:0034599,GO:0055114,GO:0098869" peroxidase activity|glutathione peroxidase activity|protein binding|endoplasmic reticulum lumen|integral component of membrane|cellular response to oxidative stress|oxidation-reduction process|cellular oxidant detoxification "hsa00480,hsa00590,hsa04918,hsa05014,hsa05016,hsa05022" Glutathione metabolism|Arachidonic acid metabolism|Thyroid hormone synthesis|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases GRAMD1A 1290.136293 1230.809623 1349.462962 1.096402674 0.132777752 0.582896514 1 15.91617336 17.15852396 57655 GRAM domain containing 1A "GO:0005515,GO:0005776,GO:0005829,GO:0005886,GO:0006914,GO:0015485,GO:0015918,GO:0016021,GO:0031227,GO:0031234,GO:0031410,GO:0044232,GO:0071397,GO:0120009,GO:0120020,GO:0140268" protein binding|autophagosome|cytosol|plasma membrane|autophagy|cholesterol binding|sterol transport|integral component of membrane|intrinsic component of endoplasmic reticulum membrane|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic vesicle|organelle membrane contact site|cellular response to cholesterol|intermembrane lipid transfer|cholesterol transfer activity|endoplasmic reticulum-plasma membrane contact site GRAMD1B 7.486072413 7.282897178 7.689247648 1.055795168 0.078329968 1 1 0.020305879 0.021080099 57476 GRAM domain containing 1B "GO:0001786,GO:0005789,GO:0005886,GO:0015485,GO:0015918,GO:0016020,GO:0016021,GO:0042632,GO:0070300,GO:0071397,GO:0120009,GO:0120020,GO:0140268" phosphatidylserine binding|endoplasmic reticulum membrane|plasma membrane|cholesterol binding|sterol transport|membrane|integral component of membrane|cholesterol homeostasis|phosphatidic acid binding|cellular response to cholesterol|intermembrane lipid transfer|cholesterol transfer activity|endoplasmic reticulum-plasma membrane contact site GRAMD1C 235.4964573 265.3055401 205.6873746 0.775284883 -0.36720156 0.284279654 1 2.994684658 2.282882675 54762 GRAM domain containing 1C "GO:0005515,GO:0005789,GO:0005886,GO:0015485,GO:0015918,GO:0016021,GO:0071397,GO:0120009,GO:0120020,GO:0140268" protein binding|endoplasmic reticulum membrane|plasma membrane|cholesterol binding|sterol transport|integral component of membrane|cellular response to cholesterol|intermembrane lipid transfer|cholesterol transfer activity|endoplasmic reticulum-plasma membrane contact site GRAMD2A 4.122026567 7.282897178 0.961155956 0.131974396 -2.921670032 0.166282975 1 0.081142972 0.010529598 196996 GRAM domain containing 2A "GO:0005515,GO:0005546,GO:0016021,GO:0031227,GO:0031234,GO:0035091,GO:0044232,GO:0061817,GO:2001256" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|integral component of membrane|intrinsic component of endoplasmic reticulum membrane|extrinsic component of cytoplasmic side of plasma membrane|phosphatidylinositol binding|organelle membrane contact site|endoplasmic reticulum-plasma membrane tethering|regulation of store-operated calcium entry" GRAMD2B 319.0723661 276.7500928 361.3946395 1.305851918 0.384991306 0.213023747 1 3.004402727 3.857653867 65983 GRAM domain containing 2B "GO:0005515,GO:0005881,GO:0042802" protein binding|cytoplasmic microtubule|identical protein binding GRAMD4 267.6259848 238.2547791 296.9971904 1.246552919 0.31794413 0.333652611 1 2.275043777 2.78850647 23151 GRAM domain containing 4 "GO:0003674,GO:0005515,GO:0005739,GO:0005789,GO:0006915,GO:0016021,GO:0031966,GO:0034164,GO:0043280" molecular_function|protein binding|mitochondrion|endoplasmic reticulum membrane|apoptotic process|integral component of membrane|mitochondrial membrane|negative regulation of toll-like receptor 9 signaling pathway|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GRB10 1155.966947 1051.858435 1260.075458 1.197951565 0.260569578 0.283598209 1 4.734397526 5.576672731 2887 growth factor receptor bound protein 10 "GO:0005158,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007411,GO:0008286,GO:0030178,GO:0030949,GO:0032991,GO:0046325,GO:0046627,GO:0120162" insulin receptor binding|protein binding|cytoplasm|cytosol|plasma membrane|axon guidance|insulin receptor signaling pathway|negative regulation of Wnt signaling pathway|positive regulation of vascular endothelial growth factor receptor signaling pathway|protein-containing complex|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|positive regulation of cold-induced thermogenesis hsa04150 mTOR signaling pathway GRB14 77.3082734 61.38441908 93.23212773 1.518823981 0.602954683 0.241732867 1 0.907471919 1.355226293 2888 growth factor receptor bound protein 14 "GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0008286,GO:0010008,GO:0030674,GO:0030971,GO:0043231,GO:0046627,GO:0050900" protein binding|cytoplasm|cytosol|plasma membrane|signal transduction|insulin receptor signaling pathway|endosome membrane|protein-macromolecule adaptor activity|receptor tyrosine kinase binding|intracellular membrane-bounded organelle|negative regulation of insulin receptor signaling pathway|leukocyte migration GRB2 3421.61064 3340.768977 3502.452304 1.048397039 0.068185184 0.774696062 1 54.47317453 56.15386449 2885 growth factor receptor bound protein 2 "GO:0000165,GO:0001784,GO:0003723,GO:0005154,GO:0005168,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005768,GO:0005794,GO:0005829,GO:0005886,GO:0005911,GO:0007173,GO:0007265,GO:0007411,GO:0007568,GO:0008180,GO:0008286,GO:0008543,GO:0012506,GO:0016032,GO:0017124,GO:0019221,GO:0019901,GO:0019903,GO:0030674,GO:0030838,GO:0031295,GO:0031532,GO:0031623,GO:0035635,GO:0035723,GO:0038095,GO:0038096,GO:0038128,GO:0042059,GO:0042770,GO:0042802,GO:0043408,GO:0043560,GO:0044877,GO:0046579,GO:0046875,GO:0048011,GO:0048646,GO:0050900,GO:0051897,GO:0060670,GO:0061024,GO:0070062,GO:0070436,GO:0071479,GO:2000379" MAPK cascade|phosphotyrosine residue binding|RNA binding|epidermal growth factor receptor binding|neurotrophin TRKA receptor binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|endosome|Golgi apparatus|cytosol|plasma membrane|cell-cell junction|epidermal growth factor receptor signaling pathway|Ras protein signal transduction|axon guidance|aging|COP9 signalosome|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|vesicle membrane|viral process|SH3 domain binding|cytokine-mediated signaling pathway|protein kinase binding|protein phosphatase binding|protein-macromolecule adaptor activity|positive regulation of actin filament polymerization|T cell costimulation|actin cytoskeleton reorganization|receptor internalization|entry of bacterium into host cell|interleukin-15-mediated signaling pathway|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|ERBB2 signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|signal transduction in response to DNA damage|identical protein binding|regulation of MAPK cascade|insulin receptor substrate binding|protein-containing complex binding|positive regulation of Ras protein signal transduction|ephrin receptor binding|neurotrophin TRK receptor signaling pathway|anatomical structure formation involved in morphogenesis|leukocyte migration|positive regulation of protein kinase B signaling|branching involved in labyrinthine layer morphogenesis|membrane organization|extracellular exosome|Grb2-EGFR complex|cellular response to ionizing radiation|positive regulation of reactive oxygen species metabolic process "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04062,hsa04068,hsa04072,hsa04150,hsa04151,hsa04380,hsa04510,hsa04540,hsa04550,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04714,hsa04722,hsa04910,hsa04912,hsa04915,hsa04917,hsa04926,hsa04935,hsa05034,hsa05160,hsa05161,hsa05163,hsa05165,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05213,hsa05214,hsa05215,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05231" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Osteoclast differentiation|Focal adhesion|Gap junction|Signaling pathways regulating pluripotency of stem cells|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Thermogenesis|Neurotrophin signaling pathway|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Alcoholism|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Endometrial cancer|Glioma|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Choline metabolism in cancer" GRB7 7.887392465 5.202069413 10.57271552 2.032405698 1.023188414 0.464422034 1 0.103901528 0.207636413 2886 growth factor receptor bound protein 7 "GO:0003723,GO:0005515,GO:0005829,GO:0005886,GO:0005925,GO:0007173,GO:0007411,GO:0008286,GO:0010494,GO:0017148,GO:0019901,GO:0030335,GO:0034063,GO:0035091,GO:0038128,GO:0042802,GO:0042995,GO:0046627,GO:0050900" RNA binding|protein binding|cytosol|plasma membrane|focal adhesion|epidermal growth factor receptor signaling pathway|axon guidance|insulin receptor signaling pathway|cytoplasmic stress granule|negative regulation of translation|protein kinase binding|positive regulation of cell migration|stress granule assembly|phosphatidylinositol binding|ERBB2 signaling pathway|identical protein binding|cell projection|negative regulation of insulin receptor signaling pathway|leukocyte migration GREB1 17.93487062 16.64662212 19.22311912 1.154775965 0.207612985 0.876458915 1 0.058512786 0.06643848 9687 growth regulating estrogen receptor binding 1 "GO:0005654,GO:0007275,GO:0016021,GO:0070062" nucleoplasm|multicellular organism development|integral component of membrane|extracellular exosome GREB1L 419.6062839 443.216314 395.9962539 0.893460465 -0.162524203 0.573330524 1 1.739366136 1.528049872 80000 GREB1 like retinoic acid receptor coactivator "GO:0001822,GO:0007275,GO:0016021" kidney development|multicellular organism development|integral component of membrane GREM1 16.21070353 21.84869154 10.57271552 0.483906119 -1.047200914 0.266820442 1 0.078817393 0.037501994 26585 "gremlin 1, DAN family BMP antagonist" "GO:0000902,GO:0002042,GO:0002092,GO:0003257,GO:0003337,GO:0005125,GO:0005515,GO:0005615,GO:0006915,GO:0007165,GO:0007171,GO:0007267,GO:0008284,GO:0009887,GO:0009954,GO:0009986,GO:0010717,GO:0016015,GO:0030199,GO:0030297,GO:0030308,GO:0030326,GO:0030502,GO:0030514,GO:0032331,GO:0032872,GO:0033689,GO:0036122,GO:0038098,GO:0042803,GO:0043066,GO:0043184,GO:0045668,GO:0045766,GO:0045892,GO:0045944,GO:0046851,GO:0048018,GO:0048263,GO:0051092,GO:0051893,GO:0051973,GO:0060173,GO:0060394,GO:0060676,GO:0061098,GO:0062023,GO:0072331,GO:0090027,GO:0090090,GO:0090190,GO:0090291,GO:1900086,GO:1900155,GO:1900158,GO:1901224,GO:2000273,GO:2000727" "cell morphogenesis|cell migration involved in sprouting angiogenesis|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|cytokine activity|protein binding|extracellular space|apoptotic process|signal transduction|activation of transmembrane receptor protein tyrosine kinase activity|cell-cell signaling|positive regulation of cell population proliferation|animal organ morphogenesis|proximal/distal pattern formation|cell surface|regulation of epithelial to mesenchymal transition|morphogen activity|collagen fibril organization|transmembrane receptor protein tyrosine kinase activator activity|negative regulation of cell growth|embryonic limb morphogenesis|negative regulation of bone mineralization|negative regulation of BMP signaling pathway|negative regulation of chondrocyte differentiation|regulation of stress-activated MAPK cascade|negative regulation of osteoblast proliferation|BMP binding|sequestering of BMP from receptor via BMP binding|protein homodimerization activity|negative regulation of apoptotic process|vascular endothelial growth factor receptor 2 binding|negative regulation of osteoblast differentiation|positive regulation of angiogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of bone remodeling|receptor ligand activity|determination of dorsal identity|positive regulation of NF-kappaB transcription factor activity|regulation of focal adhesion assembly|positive regulation of telomerase activity|limb development|negative regulation of pathway-restricted SMAD protein phosphorylation|ureteric bud formation|positive regulation of protein tyrosine kinase activity|collagen-containing extracellular matrix|signal transduction by p53 class mediator|negative regulation of monocyte chemotaxis|negative regulation of canonical Wnt signaling pathway|positive regulation of branching involved in ureteric bud morphogenesis|negative regulation of osteoclast proliferation|positive regulation of peptidyl-tyrosine autophosphorylation|negative regulation of bone trabecula formation|negative regulation of bone mineralization involved in bone maturation|positive regulation of NIK/NF-kappaB signaling|positive regulation of signaling receptor activity|positive regulation of cardiac muscle cell differentiation" hsa04350 TGF-beta signaling pathway GREM2 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.037695164 0.03424085 64388 "gremlin 2, DAN family BMP antagonist" "GO:0005125,GO:0005576,GO:0005615,GO:0008201,GO:0009887,GO:0010172,GO:0019221,GO:0030509,GO:0036122,GO:0038098,GO:0048018,GO:0060300" cytokine activity|extracellular region|extracellular space|heparin binding|animal organ morphogenesis|embryonic body morphogenesis|cytokine-mediated signaling pathway|BMP signaling pathway|BMP binding|sequestering of BMP from receptor via BMP binding|receptor ligand activity|regulation of cytokine activity hsa04350 TGF-beta signaling pathway GRHL1 53.2793745 61.38441908 45.17432993 0.735925022 -0.442369308 0.460175948 1 0.869419752 0.629121099 29841 grainyhead like transcription factor 1 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0002934,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008544,GO:0019216,GO:0031490,GO:0042803,GO:0043231,GO:0043565,GO:0045616,GO:0045944,GO:0061436,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|desmosome organization|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|epidermis development|regulation of lipid metabolic process|chromatin DNA binding|protein homodimerization activity|intracellular membrane-bounded organelle|sequence-specific DNA binding|regulation of keratinocyte differentiation|positive regulation of transcription by RNA polymerase II|establishment of skin barrier|sequence-specific double-stranded DNA binding" CP2 GRHPR 2566.528938 2479.306282 2653.751594 1.070360533 0.098096826 0.679141886 1 42.23300974 44.44810996 9380 glyoxylate and hydroxypyruvate reductase "GO:0005737,GO:0005782,GO:0005829,GO:0007588,GO:0008465,GO:0016618,GO:0030267,GO:0034641,GO:0042803,GO:0046487,GO:0051287,GO:0055114,GO:0070062,GO:0070402,GO:1902494" cytoplasm|peroxisomal matrix|cytosol|excretion|glycerate dehydrogenase activity|hydroxypyruvate reductase activity|glyoxylate reductase (NADP+) activity|cellular nitrogen compound metabolic process|protein homodimerization activity|glyoxylate metabolic process|NAD binding|oxidation-reduction process|extracellular exosome|NADPH binding|catalytic complex "hsa00260,hsa00620,hsa00630" "Glycine, serine and threonine metabolism|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism" GRIA3 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.009751489 0.026573642 2892 glutamate ionotropic receptor AMPA type subunit 3 "GO:0001540,GO:0004971,GO:0005886,GO:0007215,GO:0015276,GO:0030666,GO:0032281,GO:0034220,GO:0035235,GO:0038023,GO:0043197,GO:0045211,GO:0060078,GO:0098688,GO:1904315,GO:2000310" amyloid-beta binding|AMPA glutamate receptor activity|plasma membrane|glutamate receptor signaling pathway|ligand-gated ion channel activity|endocytic vesicle membrane|AMPA glutamate receptor complex|ion transmembrane transport|ionotropic glutamate receptor signaling pathway|signaling receptor activity|dendritic spine|postsynaptic membrane|regulation of postsynaptic membrane potential|parallel fiber to Purkinje cell synapse|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential|regulation of NMDA receptor activity "hsa04024,hsa04080,hsa04713,hsa04723,hsa04724,hsa04728,hsa04730,hsa05016,hsa05017,hsa05022,hsa05031,hsa05033,hsa05202" cAMP signaling pathway|Neuroactive ligand-receptor interaction|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Dopaminergic synapse|Long-term depression|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Nicotine addiction|Transcriptional misregulation in cancer GRID2 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.008232427 0.009970697 2895 glutamate ionotropic receptor delta type subunit 2 "GO:0004970,GO:0005515,GO:0005886,GO:0005887,GO:0007157,GO:0007215,GO:0008066,GO:0008328,GO:0010975,GO:0015276,GO:0021707,GO:0030165,GO:0034220,GO:0034613,GO:0035235,GO:0035249,GO:0038023,GO:0043197,GO:0043523,GO:0045202,GO:0045211,GO:0050804,GO:0051965,GO:0060079,GO:0060134,GO:0097110,GO:0098688,GO:0098978,GO:0099061,GO:0099151,GO:1900454,GO:1904315,GO:1904861" "ionotropic glutamate receptor activity|protein binding|plasma membrane|integral component of plasma membrane|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|glutamate receptor signaling pathway|glutamate receptor activity|ionotropic glutamate receptor complex|regulation of neuron projection development|ligand-gated ion channel activity|cerebellar granule cell differentiation|PDZ domain binding|ion transmembrane transport|cellular protein localization|ionotropic glutamate receptor signaling pathway|synaptic transmission, glutamatergic|signaling receptor activity|dendritic spine|regulation of neuron apoptotic process|synapse|postsynaptic membrane|modulation of chemical synaptic transmission|positive regulation of synapse assembly|excitatory postsynaptic potential|prepulse inhibition|scaffold protein binding|parallel fiber to Purkinje cell synapse|glutamatergic synapse|integral component of postsynaptic density membrane|regulation of postsynaptic density assembly|positive regulation of long-term synaptic depression|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential|excitatory synapse assembly" "hsa04080,hsa04730" Neuroactive ligand-receptor interaction|Long-term depression GRID2IP 8.888177384 6.242483296 11.53387147 1.847641543 0.88568489 0.505027526 1 0.070225519 0.127580369 392862 Grid2 interacting protein "GO:0045211,GO:0060292" postsynaptic membrane|long-term synaptic depression GRIK2 13.49078193 13.52538047 13.45618338 0.994883908 -0.007399906 1 1 0.049511263 0.048433693 2898 glutamate ionotropic receptor kainate type subunit 2 "GO:0001662,GO:0005234,GO:0005886,GO:0005887,GO:0006874,GO:0007215,GO:0007268,GO:0008066,GO:0014069,GO:0015276,GO:0015277,GO:0019228,GO:0030165,GO:0031624,GO:0031625,GO:0032839,GO:0032983,GO:0034220,GO:0035235,GO:0035249,GO:0038023,GO:0042734,GO:0042802,GO:0043113,GO:0043195,GO:0043204,GO:0043524,GO:0043525,GO:0045211,GO:0046328,GO:0048169,GO:0048172,GO:0050804,GO:0050806,GO:0051402,GO:0051967,GO:0060079,GO:0060080,GO:0098686,GO:0098978,GO:0099505,GO:0099507,GO:0120169,GO:1904315" "behavioral fear response|extracellularly glutamate-gated ion channel activity|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|glutamate receptor signaling pathway|chemical synaptic transmission|glutamate receptor activity|postsynaptic density|ligand-gated ion channel activity|kainate selective glutamate receptor activity|neuronal action potential|PDZ domain binding|ubiquitin conjugating enzyme binding|ubiquitin protein ligase binding|dendrite cytoplasm|kainate selective glutamate receptor complex|ion transmembrane transport|ionotropic glutamate receptor signaling pathway|synaptic transmission, glutamatergic|signaling receptor activity|presynaptic membrane|identical protein binding|receptor clustering|terminal bouton|perikaryon|negative regulation of neuron apoptotic process|positive regulation of neuron apoptotic process|postsynaptic membrane|regulation of JNK cascade|regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity|modulation of chemical synaptic transmission|positive regulation of synaptic transmission|neuron apoptotic process|negative regulation of synaptic transmission, glutamatergic|excitatory postsynaptic potential|inhibitory postsynaptic potential|hippocampal mossy fiber to CA3 synapse|glutamatergic synapse|regulation of presynaptic membrane potential|ligand-gated ion channel activity involved in regulation of presynaptic membrane potential|detection of cold stimulus involved in thermoception|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential" "hsa04080,hsa04724" Neuroactive ligand-receptor interaction|Glutamatergic synapse GRIK5 2.923096831 1.040413883 4.80577978 4.619103859 2.207612985 0.416510993 1 0.006942358 0.031530865 2901 glutamate ionotropic receptor kainate type subunit 5 "GO:0005654,GO:0005783,GO:0005886,GO:0006621,GO:0008066,GO:0015276,GO:0015277,GO:0017124,GO:0030165,GO:0030425,GO:0031630,GO:0032983,GO:0034220,GO:0035235,GO:0035249,GO:0038023,GO:0042802,GO:0043113,GO:0043195,GO:0043204,GO:0043525,GO:0045211,GO:0050804,GO:0051649,GO:0060079,GO:0071333,GO:0098686,GO:0098978,GO:0099056,GO:0099061,GO:1904315" "nucleoplasm|endoplasmic reticulum|plasma membrane|protein retention in ER lumen|glutamate receptor activity|ligand-gated ion channel activity|kainate selective glutamate receptor activity|SH3 domain binding|PDZ domain binding|dendrite|regulation of synaptic vesicle fusion to presynaptic active zone membrane|kainate selective glutamate receptor complex|ion transmembrane transport|ionotropic glutamate receptor signaling pathway|synaptic transmission, glutamatergic|signaling receptor activity|identical protein binding|receptor clustering|terminal bouton|perikaryon|positive regulation of neuron apoptotic process|postsynaptic membrane|modulation of chemical synaptic transmission|establishment of localization in cell|excitatory postsynaptic potential|cellular response to glucose stimulus|hippocampal mossy fiber to CA3 synapse|glutamatergic synapse|integral component of presynaptic membrane|integral component of postsynaptic density membrane|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential" "hsa04080,hsa04724" Neuroactive ligand-receptor interaction|Glutamatergic synapse GRIN2D 580.212449 609.6825352 550.7423628 0.903326454 -0.146680636 0.582748933 1 5.661673283 5.028757711 2906 glutamate ionotropic receptor NMDA type subunit 2D "GO:0001964,GO:0004970,GO:0004972,GO:0005515,GO:0005886,GO:0005887,GO:0007420,GO:0008344,GO:0015276,GO:0017146,GO:0019722,GO:0022849,GO:0035235,GO:0038023,GO:0048167,GO:0051930,GO:0060079,GO:0060291,GO:0097553,GO:0098839,GO:0098976" startle response|ionotropic glutamate receptor activity|NMDA glutamate receptor activity|protein binding|plasma membrane|integral component of plasma membrane|brain development|adult locomotory behavior|ligand-gated ion channel activity|NMDA selective glutamate receptor complex|calcium-mediated signaling|glutamate-gated calcium ion channel activity|ionotropic glutamate receptor signaling pathway|signaling receptor activity|regulation of synaptic plasticity|regulation of sensory perception of pain|excitatory postsynaptic potential|long-term synaptic potentiation|calcium ion transmembrane import into cytosol|postsynaptic density membrane|excitatory chemical synaptic transmission "hsa04020,hsa04024,hsa04080,hsa04713,hsa04720,hsa04724,hsa05010,hsa05014,hsa05017,hsa05020,hsa05022,hsa05030,hsa05031,hsa05033,hsa05034" Calcium signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Circadian entrainment|Long-term potentiation|Glutamatergic synapse|Alzheimer disease|Amyotrophic lateral sclerosis|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Cocaine addiction|Amphetamine addiction|Nicotine addiction|Alcoholism GRIN3B 36.46920611 36.41448589 36.52392633 1.003005409 0.004329387 1 1 0.50190449 0.494988985 116444 glutamate ionotropic receptor NMDA type subunit 3B "GO:0004972,GO:0005261,GO:0005262,GO:0005886,GO:0015276,GO:0016594,GO:0017146,GO:0030594,GO:0035235,GO:0038023,GO:0042165,GO:0043025,GO:0045211,GO:0051205,GO:0051924,GO:0070588" NMDA glutamate receptor activity|cation channel activity|calcium channel activity|plasma membrane|ligand-gated ion channel activity|glycine binding|NMDA selective glutamate receptor complex|neurotransmitter receptor activity|ionotropic glutamate receptor signaling pathway|signaling receptor activity|neurotransmitter binding|neuronal cell body|postsynaptic membrane|protein insertion into membrane|regulation of calcium ion transport|calcium ion transmembrane transport "hsa04024,hsa04080,hsa04724,hsa05017,hsa05020,hsa05030,hsa05031,hsa05033,hsa05034" cAMP signaling pathway|Neuroactive ligand-receptor interaction|Glutamatergic synapse|Spinocerebellar ataxia|Prion disease|Cocaine addiction|Amphetamine addiction|Nicotine addiction|Alcoholism GRINA 3472.719868 3420.880846 3524.558891 1.030307412 0.043074857 0.85704288 1 98.25948517 99.54340379 2907 glutamate ionotropic receptor NMDA type subunit associated protein 1 "GO:0005515,GO:0005783,GO:0005794,GO:0016021,GO:0032469,GO:0044325,GO:1902236" protein binding|endoplasmic reticulum|Golgi apparatus|integral component of membrane|endoplasmic reticulum calcium ion homeostasis|ion channel binding|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GRIP1 77.66493407 70.74814402 84.58172413 1.195532763 0.257653667 0.629514201 1 0.614434242 0.722284128 23426 glutamate receptor interacting protein 1 "GO:0005515,GO:0005789,GO:0005829,GO:0005886,GO:0008013,GO:0008022,GO:0014069,GO:0016358,GO:0030159,GO:0030425,GO:0031410,GO:0035259,GO:0035556,GO:0043005,GO:0043204,GO:0045121,GO:0045211,GO:0098887,GO:0098978,GO:0099003,GO:0150012" "protein binding|endoplasmic reticulum membrane|cytosol|plasma membrane|beta-catenin binding|protein C-terminus binding|postsynaptic density|dendrite development|signaling receptor complex adaptor activity|dendrite|cytoplasmic vesicle|glucocorticoid receptor binding|intracellular signal transduction|neuron projection|perikaryon|membrane raft|postsynaptic membrane|neurotransmitter receptor transport, endosome to postsynaptic membrane|glutamatergic synapse|vesicle-mediated transport in synapse|positive regulation of neuron projection arborization" GRIPAP1 1260.112131 1300.517353 1219.706908 0.937862847 -0.092551136 0.703403979 1 22.89878617 21.11655036 56850 GRIP1 associated protein 1 "GO:0003674,GO:0005515,GO:0005654,GO:0005829,GO:0008150,GO:0030424,GO:0030425,GO:0042802,GO:0043231,GO:0055038,GO:0072562,GO:0098837,GO:0098887,GO:0098978,GO:0098998,GO:0099152,GO:0099158,GO:1905244" "molecular_function|protein binding|nucleoplasm|cytosol|biological_process|axon|dendrite|identical protein binding|intracellular membrane-bounded organelle|recycling endosome membrane|blood microparticle|postsynaptic recycling endosome|neurotransmitter receptor transport, endosome to postsynaptic membrane|glutamatergic synapse|extrinsic component of postsynaptic early endosome membrane|regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane|regulation of recycling endosome localization within postsynapse|regulation of modification of synaptic structure" GRK2 1480.330087 1417.043708 1543.616465 1.089321703 0.12343008 0.60668176 1 21.14793576 22.65141399 156 G protein-coupled receptor kinase 2 "GO:0002029,GO:0003108,GO:0004672,GO:0004703,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005929,GO:0007186,GO:0007213,GO:0007217,GO:0007507,GO:0016020,GO:0018105,GO:0018107,GO:0019079,GO:0031623,GO:0031694,GO:0031755,GO:0033605,GO:0045202,GO:0045988,GO:0046718,GO:0047696,GO:0060048,GO:1901081" desensitization of G protein-coupled receptor signaling pathway|negative regulation of the force of heart contraction by chemical signal|protein kinase activity|G protein-coupled receptor kinase activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|cilium|G protein-coupled receptor signaling pathway|G protein-coupled acetylcholine receptor signaling pathway|tachykinin receptor signaling pathway|heart development|membrane|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|viral genome replication|receptor internalization|alpha-2A adrenergic receptor binding|Edg-2 lysophosphatidic acid receptor binding|positive regulation of catecholamine secretion|synapse|negative regulation of striated muscle contraction|viral entry into host cell|beta-adrenergic receptor kinase activity|cardiac muscle contraction|negative regulation of relaxation of smooth muscle "hsa04062,hsa04144,hsa04340,hsa04724,hsa04740,hsa05032" Chemokine signaling pathway|Endocytosis|Hedgehog signaling pathway|Glutamatergic synapse|Olfactory transduction|Morphine addiction GRK3 501.2447896 492.1157665 510.3738126 1.03710112 0.052556568 0.854367603 1 5.345677587 5.451236744 157 G protein-coupled receptor kinase 3 "GO:0004672,GO:0004703,GO:0005515,GO:0005524,GO:0005829,GO:0005886,GO:0006468,GO:0007165,GO:0007186,GO:0031623,GO:0047696" protein kinase activity|G protein-coupled receptor kinase activity|protein binding|ATP binding|cytosol|plasma membrane|protein phosphorylation|signal transduction|G protein-coupled receptor signaling pathway|receptor internalization|beta-adrenergic receptor kinase activity "hsa04062,hsa04144,hsa04340,hsa04724,hsa04740,hsa05032" Chemokine signaling pathway|Endocytosis|Hedgehog signaling pathway|Glutamatergic synapse|Olfactory transduction|Morphine addiction GRK4 32.78812856 28.09117483 37.48508228 1.334407781 0.416199607 0.575229901 1 0.423017599 0.555032201 2868 G protein-coupled receptor kinase 4 "GO:0002031,GO:0004703,GO:0005524,GO:0005829,GO:0005938,GO:0006468,GO:0007165,GO:0008277,GO:0022400,GO:0030425,GO:0031623,GO:0043025,GO:0050254,GO:0097381" G protein-coupled receptor internalization|G protein-coupled receptor kinase activity|ATP binding|cytosol|cell cortex|protein phosphorylation|signal transduction|regulation of G protein-coupled receptor signaling pathway|regulation of rhodopsin mediated signaling pathway|dendrite|receptor internalization|neuronal cell body|rhodopsin kinase activity|photoreceptor disc membrane "hsa04062,hsa04144,hsa05032" Chemokine signaling pathway|Endocytosis|Morphine addiction GRK5 282.4742123 262.1842984 302.7641261 1.154775965 0.207612985 0.523802703 1 5.236637026 5.945951832 2869 G protein-coupled receptor kinase 5 "GO:0004674,GO:0004703,GO:0005080,GO:0005515,GO:0005524,GO:0005543,GO:0005737,GO:0005829,GO:0005886,GO:0006915,GO:0007186,GO:0007188,GO:0007217,GO:0008277,GO:0008284,GO:0016055,GO:0016607,GO:0031965,GO:0043066,GO:0046777,GO:0047696,GO:0051726" protein serine/threonine kinase activity|G protein-coupled receptor kinase activity|protein kinase C binding|protein binding|ATP binding|phospholipid binding|cytoplasm|cytosol|plasma membrane|apoptotic process|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|tachykinin receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|positive regulation of cell population proliferation|Wnt signaling pathway|nuclear speck|nuclear membrane|negative regulation of apoptotic process|protein autophosphorylation|beta-adrenergic receptor kinase activity|regulation of cell cycle "hsa04062,hsa04144,hsa05032" Chemokine signaling pathway|Endocytosis|Morphine addiction GRK6 1015.56898 1024.807674 1006.330286 0.981969896 -0.026249297 0.918986599 1 13.95206685 13.47125017 2870 G protein-coupled receptor kinase 6 "GO:0004703,GO:0005515,GO:0005524,GO:0005886,GO:0006468,GO:0007186,GO:0008277,GO:0016020,GO:0016055,GO:0047696" G protein-coupled receptor kinase activity|protein binding|ATP binding|plasma membrane|protein phosphorylation|G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|membrane|Wnt signaling pathway|beta-adrenergic receptor kinase activity "hsa04062,hsa04144,hsa05032" Chemokine signaling pathway|Endocytosis|Morphine addiction GRK7 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.008530493 0.030995097 131890 G protein-coupled receptor kinase 7 "GO:0004703,GO:0005524,GO:0007165,GO:0007601,GO:0022400,GO:0046777,GO:0050254,GO:0097381" G protein-coupled receptor kinase activity|ATP binding|signal transduction|visual perception|regulation of rhodopsin mediated signaling pathway|protein autophosphorylation|rhodopsin kinase activity|photoreceptor disc membrane "hsa04062,hsa04144,hsa04744" Chemokine signaling pathway|Endocytosis|Phototransduction GRN 5204.640802 5513.153164 4896.12844 0.888081338 -0.171236278 0.476520995 1 116.387204 101.6316924 2896 granulin precursor "GO:0002265,GO:0002282,GO:0003723,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005764,GO:0005765,GO:0005768,GO:0005770,GO:0005783,GO:0005794,GO:0005802,GO:0005886,GO:0007040,GO:0007041,GO:0007042,GO:0007165,GO:0008083,GO:0010595,GO:0016020,GO:0030335,GO:0035578,GO:0043312,GO:0043524,GO:0043525,GO:0045766,GO:0048680,GO:0050679,GO:0050727,GO:0050821,GO:0051087,GO:0060266,GO:0070062,GO:0106016,GO:1900426,GO:1902564,GO:1903334,GO:1903979,GO:1905247,GO:1905673" astrocyte activation involved in immune response|microglial cell activation involved in immune response|RNA binding|cytokine activity|protein binding|extracellular region|extracellular space|lysosome|lysosomal membrane|endosome|late endosome|endoplasmic reticulum|Golgi apparatus|trans-Golgi network|plasma membrane|lysosome organization|lysosomal transport|lysosomal lumen acidification|signal transduction|growth factor activity|positive regulation of endothelial cell migration|membrane|positive regulation of cell migration|azurophil granule lumen|neutrophil degranulation|negative regulation of neuron apoptotic process|positive regulation of neuron apoptotic process|positive regulation of angiogenesis|positive regulation of axon regeneration|positive regulation of epithelial cell proliferation|regulation of inflammatory response|protein stabilization|chaperone binding|negative regulation of respiratory burst involved in inflammatory response|extracellular exosome|positive regulation of inflammatory response to wounding|positive regulation of defense response to bacterium|negative regulation of neutrophil activation|positive regulation of protein folding|negative regulation of microglial cell activation|positive regulation of aspartic-type peptidase activity|positive regulation of lysosome organization GRPEL1 1057.265408 1009.201466 1105.329349 1.09525143 0.131262099 0.593538292 1 20.30125421 21.86290547 80273 "GrpE like 1, mitochondrial" "GO:0000774,GO:0001405,GO:0005515,GO:0005654,GO:0005739,GO:0005759,GO:0006457,GO:0030150,GO:0042802,GO:0042803,GO:0050790,GO:0051082,GO:0051087" "adenyl-nucleotide exchange factor activity|PAM complex, Tim23 associated import motor|protein binding|nucleoplasm|mitochondrion|mitochondrial matrix|protein folding|protein import into mitochondrial matrix|identical protein binding|protein homodimerization activity|regulation of catalytic activity|unfolded protein binding|chaperone binding" GRPEL2 475.2885483 504.6007331 445.9763636 0.883820285 -0.178175052 0.522642065 1 6.698908883 5.821557805 134266 "GrpE like 2, mitochondrial" "GO:0000774,GO:0001405,GO:0005739,GO:0006457,GO:0030150,GO:0042803,GO:0050790,GO:0051082,GO:0051087" "adenyl-nucleotide exchange factor activity|PAM complex, Tim23 associated import motor|mitochondrion|protein folding|protein import into mitochondrial matrix|protein homodimerization activity|regulation of catalytic activity|unfolded protein binding|chaperone binding" GRPR 70.14426312 49.93986637 90.34865986 1.809149011 0.855311241 0.107793632 1 1.102688822 1.961545967 2925 gastrin releasing peptide receptor "GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0007200,GO:0007218,GO:0007611,GO:0008188,GO:0008528,GO:0035176,GO:0036343,GO:0042127,GO:0042923,GO:0043207,GO:0061744" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|learning or memory|neuropeptide receptor activity|G protein-coupled peptide receptor activity|social behavior|psychomotor behavior|regulation of cell population proliferation|neuropeptide binding|response to external biotic stimulus|motor behavior "hsa04020,hsa04080" Calcium signaling pathway|Neuroactive ligand-receptor interaction GRSF1 2186.18601 2095.39356 2276.97846 1.08665909 0.119899405 0.612985792 1 16.5694626 17.70406189 2926 G-rich RNA sequence binding factor 1 "GO:0000962,GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0006378,GO:0008033,GO:0009952,GO:0016331,GO:0035770,GO:0042645,GO:0043484,GO:1990904" positive regulation of mitochondrial RNA catabolic process|RNA binding|mRNA binding|protein binding|nucleoplasm|cytoplasm|mitochondrion|mRNA polyadenylation|tRNA processing|anterior/posterior pattern specification|morphogenesis of embryonic epithelium|ribonucleoprotein granule|mitochondrial nucleoid|regulation of RNA splicing|ribonucleoprotein complex GRTP1 12.48999701 12.48496659 12.49502743 1.000805836 0.001162108 1 1 0.114582927 0.112756327 79774 growth hormone regulated TBC protein 1 "GO:0005096,GO:0006886,GO:0090630" GTPase activator activity|intracellular protein transport|activation of GTPase activity GRWD1 476.8441387 520.2069413 433.4813362 0.833286336 -0.263115771 0.342291145 1 5.178602566 4.243048747 83743 glutamate rich WD repeat containing 1 "GO:0003682,GO:0003688,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005829,GO:0006260,GO:0006334,GO:0006337,GO:0032991,GO:0042393" chromatin binding|DNA replication origin binding|RNA binding|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|cytosol|DNA replication|nucleosome assembly|nucleosome disassembly|protein-containing complex|histone binding GSAP 542.1530539 544.1364606 540.1696473 0.992709892 -0.010555926 0.976322939 1 8.189386019 7.993645253 54103 gamma-secretase activating protein "GO:0001540,GO:0005515,GO:0005802,GO:0030162,GO:1902004" amyloid-beta binding|protein binding|trans-Golgi network|regulation of proteolysis|positive regulation of amyloid-beta formation GSDMA 7.084752362 9.363724944 4.80577978 0.513233762 -0.962312016 0.521952192 1 0.246534184 0.124412364 284110 gasdermin A "GO:0001786,GO:0005515,GO:0005546,GO:0005829,GO:0005886,GO:0006915,GO:0016021,GO:0042742,GO:0048471,GO:0070269,GO:0070273" "phosphatidylserine binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytosol|plasma membrane|apoptotic process|integral component of membrane|defense response to bacterium|perinuclear region of cytoplasm|pyroptosis|phosphatidylinositol-4-phosphate binding" GSDMB 352.7763769 417.2059669 288.3467868 0.691137734 -0.532954846 0.075034531 1 7.989061953 5.429146648 55876 gasdermin B "GO:0001786,GO:0003674,GO:0005546,GO:0005575,GO:0005737,GO:0005886,GO:0016021,GO:0019835,GO:0042742,GO:0070269,GO:0070273" "phosphatidylserine binding|molecular_function|phosphatidylinositol-4,5-bisphosphate binding|cellular_component|cytoplasm|plasma membrane|integral component of membrane|cytolysis|defense response to bacterium|pyroptosis|phosphatidylinositol-4-phosphate binding" GSDMC 15.37346488 12.48496659 18.26196316 1.462716222 0.548649903 0.600554067 1 0.149294134 0.214720743 56169 gasdermin C "GO:0001786,GO:0003674,GO:0005546,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016021,GO:0042742,GO:0070269,GO:0070273" "phosphatidylserine binding|molecular_function|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|cytosol|plasma membrane|biological_process|integral component of membrane|defense response to bacterium|pyroptosis|phosphatidylinositol-4-phosphate binding" GSDMD 1152.676514 1167.344376 1138.008652 0.974869691 -0.036718705 0.883318118 1 26.71484729 25.60769231 79792 gasdermin D "GO:0001786,GO:0005515,GO:0005546,GO:0005576,GO:0005615,GO:0005654,GO:0005829,GO:0005886,GO:0006954,GO:0016021,GO:0032731,GO:0035580,GO:0035915,GO:0042742,GO:0043312,GO:0045087,GO:0046931,GO:0050829,GO:0050830,GO:0051260,GO:0070269,GO:0070273,GO:0070300,GO:0072559,GO:1901612,GO:1904724,GO:1904813" "phosphatidylserine binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular region|extracellular space|nucleoplasm|cytosol|plasma membrane|inflammatory response|integral component of membrane|positive regulation of interleukin-1 beta production|specific granule lumen|pore formation in membrane of other organism|defense response to bacterium|neutrophil degranulation|innate immune response|pore complex assembly|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|protein homooligomerization|pyroptosis|phosphatidylinositol-4-phosphate binding|phosphatidic acid binding|NLRP3 inflammasome complex|cardiolipin binding|tertiary granule lumen|ficolin-1-rich granule lumen" "hsa04621,hsa05132" NOD-like receptor signaling pathway|Salmonella infection GSDME 2570.708872 2740.450167 2400.967578 0.876121597 -0.190796979 0.419893468 1 54.18776905 46.6806437 1687 gasdermin E "GO:0005515,GO:0005546,GO:0005829,GO:0005886,GO:0007605,GO:0008219,GO:0008285,GO:0016020,GO:0016021,GO:0043410,GO:0060113,GO:0070265,GO:0070269,GO:0071356,GO:0098586,GO:1901612,GO:2001244" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytosol|plasma membrane|sensory perception of sound|cell death|negative regulation of cell population proliferation|membrane|integral component of membrane|positive regulation of MAPK cascade|inner ear receptor cell differentiation|necrotic cell death|pyroptosis|cellular response to tumor necrosis factor|cellular response to virus|cardiolipin binding|positive regulation of intrinsic apoptotic signaling pathway" GSE1 583.165114 636.7332962 529.5969318 0.831740597 -0.265794444 0.315557298 1 2.334360497 1.909092641 23199 Gse1 coiled-coil protein GO:0005515 protein binding GSK3A 983.3903773 974.867808 991.9129466 1.017484564 0.025006908 0.923413723 1 23.72407806 23.7349517 2931 glycogen synthase kinase 3 alpha "GO:0003073,GO:0003214,GO:0004674,GO:0005102,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005874,GO:0005977,GO:0006349,GO:0006468,GO:0007165,GO:0007212,GO:0007399,GO:0007568,GO:0008286,GO:0010508,GO:0010628,GO:0010800,GO:0010905,GO:0010975,GO:0016055,GO:0016477,GO:0018105,GO:0018107,GO:0030424,GO:0030877,GO:0031398,GO:0032007,GO:0032436,GO:0032869,GO:0033138,GO:0034236,GO:0036016,GO:0036498,GO:0043025,GO:0043161,GO:0043525,GO:0044027,GO:0045719,GO:0045732,GO:0045823,GO:0045944,GO:0046325,GO:0046627,GO:0048156,GO:0050321,GO:0060079,GO:0061052,GO:0071285,GO:0071879,GO:0090090,GO:0097191,GO:0097192,GO:0097440,GO:0098794,GO:0106071,GO:0106310,GO:0106311,GO:1901030,GO:1902004,GO:1903146,GO:1903955,GO:1904227,GO:1990635,GO:2000077,GO:2000171,GO:2000466,GO:2000467" "regulation of systemic arterial blood pressure|cardiac left ventricle morphogenesis|protein serine/threonine kinase activity|signaling receptor binding|protein binding|ATP binding|nucleus|cytoplasm|mitochondrion|cytosol|microtubule|glycogen metabolic process|regulation of gene expression by genetic imprinting|protein phosphorylation|signal transduction|dopamine receptor signaling pathway|nervous system development|aging|insulin receptor signaling pathway|positive regulation of autophagy|positive regulation of gene expression|positive regulation of peptidyl-threonine phosphorylation|negative regulation of UDP-glucose catabolic process|regulation of neuron projection development|Wnt signaling pathway|cell migration|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|axon|beta-catenin destruction complex|positive regulation of protein ubiquitination|negative regulation of TOR signaling|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|cellular response to insulin stimulus|positive regulation of peptidyl-serine phosphorylation|protein kinase A catalytic subunit binding|cellular response to interleukin-3|IRE1-mediated unfolded protein response|neuronal cell body|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of neuron apoptotic process|hypermethylation of CpG island|negative regulation of glycogen biosynthetic process|positive regulation of protein catabolic process|positive regulation of heart contraction|positive regulation of transcription by RNA polymerase II|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|tau protein binding|tau-protein kinase activity|excitatory postsynaptic potential|negative regulation of cell growth involved in cardiac muscle cell development|cellular response to lithium ion|positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway|negative regulation of canonical Wnt signaling pathway|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|apical dendrite|postsynapse|positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|protein serine kinase activity|protein threonine kinase activity|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of amyloid-beta formation|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion|negative regulation of glycogen synthase activity, transferring glucose-1-phosphate|proximal dendrite|negative regulation of type B pancreatic cell development|negative regulation of dendrite development|negative regulation of glycogen (starch) synthase activity|positive regulation of glycogen (starch) synthase activity" "hsa04062,hsa04728,hsa04932,hsa05131" Chemokine signaling pathway|Dopaminergic synapse|Non-alcoholic fatty liver disease|Shigellosis GSK3B 2566.814559 2764.379686 2369.249432 0.857063682 -0.222525691 0.346697932 1 20.7059457 17.44935353 2932 glycogen synthase kinase 3 beta "GO:0001085,GO:0001837,GO:0001954,GO:0002020,GO:0002039,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005813,GO:0005829,GO:0005886,GO:0005977,GO:0006468,GO:0006983,GO:0007165,GO:0007212,GO:0007623,GO:0008013,GO:0008286,GO:0010508,GO:0010628,GO:0010822,GO:0010975,GO:0016055,GO:0016301,GO:0018105,GO:0018107,GO:0019901,GO:0021766,GO:0030010,GO:0030011,GO:0030424,GO:0030425,GO:0030516,GO:0030877,GO:0031175,GO:0031333,GO:0031334,GO:0031625,GO:0032091,GO:0032092,GO:0032436,GO:0032515,GO:0032886,GO:0034236,GO:0034452,GO:0035556,GO:0036016,GO:0042752,GO:0043066,GO:0043547,GO:0045719,GO:0045732,GO:0046777,GO:0046827,GO:0048156,GO:0048814,GO:0050321,GO:0050770,GO:0051059,GO:0060079,GO:0070507,GO:0070885,GO:0071109,GO:0090090,GO:0097191,GO:0097192,GO:0098794,GO:0098978,GO:0106027,GO:0106310,GO:0106311,GO:0150101,GO:1900034,GO:1900181,GO:1900271,GO:1901030,GO:1901215,GO:1901216,GO:1901984,GO:1902042,GO:1904339,GO:1904646,GO:1904781,GO:1904885,GO:1904886,GO:1990909,GO:2000077,GO:2000300,GO:2000466" RNA polymerase II transcription factor binding|epithelial to mesenchymal transition|positive regulation of cell-matrix adhesion|protease binding|p53 binding|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|centrosome|cytosol|plasma membrane|glycogen metabolic process|protein phosphorylation|ER overload response|signal transduction|dopamine receptor signaling pathway|circadian rhythm|beta-catenin binding|insulin receptor signaling pathway|positive regulation of autophagy|positive regulation of gene expression|positive regulation of mitochondrion organization|regulation of neuron projection development|Wnt signaling pathway|kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein kinase binding|hippocampus development|establishment of cell polarity|maintenance of cell polarity|axon|dendrite|regulation of axon extension|beta-catenin destruction complex|neuron projection development|negative regulation of protein-containing complex assembly|positive regulation of protein-containing complex assembly|ubiquitin protein ligase binding|negative regulation of protein binding|positive regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of phosphoprotein phosphatase activity|regulation of microtubule-based process|protein kinase A catalytic subunit binding|dynactin binding|intracellular signal transduction|cellular response to interleukin-3|regulation of circadian rhythm|negative regulation of apoptotic process|positive regulation of GTPase activity|negative regulation of glycogen biosynthetic process|positive regulation of protein catabolic process|protein autophosphorylation|positive regulation of protein export from nucleus|tau protein binding|regulation of dendrite morphogenesis|tau-protein kinase activity|regulation of axonogenesis|NF-kappaB binding|excitatory postsynaptic potential|regulation of microtubule cytoskeleton organization|negative regulation of calcineurin-NFAT signaling cascade|superior temporal gyrus development|negative regulation of canonical Wnt signaling pathway|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|postsynapse|glutamatergic synapse|neuron projection organization|protein serine kinase activity|protein threonine kinase activity|regulation of microtubule anchoring at centrosome|regulation of cellular response to heat|negative regulation of protein localization to nucleus|regulation of long-term synaptic potentiation|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|negative regulation of neuron death|positive regulation of neuron death|negative regulation of protein acetylation|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of dopaminergic neuron differentiation|cellular response to amyloid-beta|positive regulation of protein localization to centrosome|beta-catenin destruction complex assembly|beta-catenin destruction complex disassembly|Wnt signalosome|negative regulation of type B pancreatic cell development|regulation of synaptic vesicle exocytosis|negative regulation of glycogen (starch) synthase activity "hsa01521,hsa04012,hsa04062,hsa04110,hsa04150,hsa04151,hsa04310,hsa04340,hsa04360,hsa04390,hsa04510,hsa04550,hsa04657,hsa04660,hsa04662,hsa04722,hsa04728,hsa04910,hsa04916,hsa04917,hsa04919,hsa04931,hsa04932,hsa04934,hsa04935,hsa05010,hsa05020,hsa05022,hsa05131,hsa05135,hsa05160,hsa05162,hsa05163,hsa05165,hsa05167,hsa05200,hsa05210,hsa05213,hsa05215,hsa05217,hsa05224,hsa05225,hsa05226" "EGFR tyrosine kinase inhibitor resistance|ErbB signaling pathway|Chemokine signaling pathway|Cell cycle|mTOR signaling pathway|PI3K-Akt signaling pathway|Wnt signaling pathway|Hedgehog signaling pathway|Axon guidance|Hippo signaling pathway|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|IL-17 signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Neurotrophin signaling pathway|Dopaminergic synapse|Insulin signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Cushing syndrome|Growth hormone synthesis, secretion and action|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Shigellosis|Yersinia infection|Hepatitis C|Measles|Human cytomegalovirus infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Prostate cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer" GSKIP 612.0010214 434.8930029 789.1090399 1.81449008 0.85956417 0.001093102 0.207613532 8.589726228 15.32516288 51527 GSK3B interacting protein "GO:0004860,GO:0005515,GO:0005634,GO:0005737,GO:0006469,GO:0008013,GO:0008631,GO:0019207,GO:0019901,GO:0030111,GO:0034237,GO:0051018,GO:0090263" protein kinase inhibitor activity|protein binding|nucleus|cytoplasm|negative regulation of protein kinase activity|beta-catenin binding|intrinsic apoptotic signaling pathway in response to oxidative stress|kinase regulator activity|protein kinase binding|regulation of Wnt signaling pathway|protein kinase A regulatory subunit binding|protein kinase A binding|positive regulation of canonical Wnt signaling pathway GSN 4128.286752 3573.821687 4682.751818 1.310292518 0.389888924 0.102123999 1 34.285151 44.17184162 2934 gelsolin "GO:0001726,GO:0002102,GO:0003779,GO:0005509,GO:0005515,GO:0005546,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0006911,GO:0007417,GO:0007568,GO:0008154,GO:0010628,GO:0014003,GO:0014891,GO:0015629,GO:0016528,GO:0022617,GO:0030027,GO:0030031,GO:0030041,GO:0030042,GO:0030155,GO:0030478,GO:0030864,GO:0031648,GO:0032991,GO:0034774,GO:0035994,GO:0036313,GO:0042060,GO:0042246,GO:0042989,GO:0043209,GO:0043312,GO:0044267,GO:0045010,GO:0045159,GO:0045335,GO:0045471,GO:0046597,GO:0048015,GO:0048471,GO:0051014,GO:0051015,GO:0051016,GO:0051127,GO:0051593,GO:0051693,GO:0055119,GO:0060271,GO:0070062,GO:0071276,GO:0071346,GO:0071801,GO:0072562,GO:0086003,GO:0090527,GO:0097017,GO:0097284,GO:1902174,GO:1903903,GO:1903906,GO:1903909,GO:1903923,GO:1904813,GO:1990000,GO:2001269" "ruffle|podosome|actin binding|calcium ion binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular region|extracellular space|nucleus|cytoplasm|cytosol|plasma membrane|focal adhesion|phagocytosis, engulfment|central nervous system development|aging|actin polymerization or depolymerization|positive regulation of gene expression|oligodendrocyte development|striated muscle atrophy|actin cytoskeleton|sarcoplasm|extracellular matrix disassembly|lamellipodium|cell projection assembly|actin filament polymerization|actin filament depolymerization|regulation of cell adhesion|actin cap|cortical actin cytoskeleton|protein destabilization|protein-containing complex|secretory granule lumen|response to muscle stretch|phosphatidylinositol 3-kinase catalytic subunit binding|wound healing|tissue regeneration|sequestering of actin monomers|myelin sheath|neutrophil degranulation|cellular protein metabolic process|actin nucleation|myosin II binding|phagocytic vesicle|response to ethanol|negative regulation of viral entry into host cell|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|actin filament severing|actin filament binding|barbed-end actin filament capping|positive regulation of actin nucleation|response to folic acid|actin filament capping|relaxation of cardiac muscle|cilium assembly|extracellular exosome|cellular response to cadmium ion|cellular response to interferon-gamma|regulation of podosome assembly|blood microparticle|cardiac muscle cell contraction|actin filament reorganization|renal protein absorption|hepatocyte apoptotic process|positive regulation of keratinocyte apoptotic process|regulation of establishment of T cell polarity|regulation of plasma membrane raft polarization|regulation of receptor clustering|positive regulation of protein processing in phagocytic vesicle|ficolin-1-rich granule lumen|amyloid fibril formation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway" "hsa04666,hsa04810,hsa05203" Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Viral carcinogenesis GSPT1 3559.144646 3418.800018 3699.489275 1.082101689 0.113836081 0.632170786 1 23.53044538 25.03625701 2935 G1 to S phase transition 1 "GO:0000082,GO:0000184,GO:0002184,GO:0003723,GO:0003747,GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0006412,GO:0006449,GO:0006479,GO:0018444" "G1/S transition of mitotic cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translational termination|RNA binding|translation release factor activity|GTPase activity|protein binding|GTP binding|cytosol|translation|regulation of translational termination|protein methylation|translation release factor complex" hsa03015 mRNA surveillance pathway GSR 1181.98171 1192.31431 1171.64911 0.982667994 -0.025224028 0.920729116 1 20.97284882 20.26447775 2936 glutathione-disulfide reductase "GO:0004362,GO:0005739,GO:0005759,GO:0005829,GO:0006749,GO:0009055,GO:0009897,GO:0015949,GO:0022900,GO:0034599,GO:0045454,GO:0050660,GO:0050661,GO:0070062,GO:0098869" glutathione-disulfide reductase activity|mitochondrion|mitochondrial matrix|cytosol|glutathione metabolic process|electron transfer activity|external side of plasma membrane|nucleobase-containing small molecule interconversion|electron transport chain|cellular response to oxidative stress|cell redox homeostasis|flavin adenine dinucleotide binding|NADP binding|extracellular exosome|cellular oxidant detoxification "hsa00480,hsa04918" Glutathione metabolism|Thyroid hormone synthesis GSS 2303.857188 2270.183092 2337.531285 1.029666415 0.042177017 0.860063692 1 40.56093043 41.06536002 2937 glutathione synthetase "GO:0000287,GO:0004363,GO:0005515,GO:0005524,GO:0005829,GO:0006520,GO:0006750,GO:0006979,GO:0007399,GO:0007568,GO:0009410,GO:0016594,GO:0031667,GO:0034612,GO:0042802,GO:0042803,GO:0043200,GO:0043295,GO:0046686,GO:0070062" magnesium ion binding|glutathione synthase activity|protein binding|ATP binding|cytosol|cellular amino acid metabolic process|glutathione biosynthetic process|response to oxidative stress|nervous system development|aging|response to xenobiotic stimulus|glycine binding|response to nutrient levels|response to tumor necrosis factor|identical protein binding|protein homodimerization activity|response to amino acid|glutathione binding|response to cadmium ion|extracellular exosome "hsa00270,hsa00480,hsa04216" Cysteine and methionine metabolism|Glutathione metabolism|Ferroptosis GSTA4 73.81527983 83.23311061 64.39744905 0.773699896 -0.370154014 0.486509064 1 3.579369974 2.723016719 2941 glutathione S-transferase alpha 4 "GO:0004364,GO:0005515,GO:0005829,GO:0006749,GO:0006805,GO:0042802,GO:0042803,GO:1901687" glutathione transferase activity|protein binding|cytosol|glutathione metabolic process|xenobiotic metabolic process|identical protein binding|protein homodimerization activity|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTCD 490.0575179 526.4494246 453.6656112 0.861745858 -0.214665635 0.436464022 1 5.941137285 5.034078358 79807 glutathione S-transferase C-terminal domain containing "GO:0003674,GO:0005515,GO:0005737,GO:0008150,GO:0070062" molecular_function|protein binding|cytoplasm|biological_process|extracellular exosome GSTK1 1778.584114 1677.147179 1880.02105 1.120963666 0.164739517 0.488025194 1 86.73087448 95.59527785 373156 glutathione S-transferase kappa 1 "GO:0004364,GO:0004602,GO:0005515,GO:0005739,GO:0005759,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0006749,GO:0016020,GO:0030855,GO:0055114,GO:0070062,GO:0098869,GO:1901687" glutathione transferase activity|glutathione peroxidase activity|protein binding|mitochondrion|mitochondrial matrix|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|glutathione metabolic process|membrane|epithelial cell differentiation|oxidation-reduction process|extracellular exosome|cellular oxidant detoxification|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa04146,hsa05204" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Peroxisome|Chemical carcinogenesis GSTM2 2.923096831 1.040413883 4.80577978 4.619103859 2.207612985 0.416510993 1 0.028000493 0.127172901 2946 glutathione S-transferase mu 2 "GO:0004364,GO:0004602,GO:0005102,GO:0005504,GO:0005515,GO:0005737,GO:0005829,GO:0006749,GO:0010880,GO:0010881,GO:0014809,GO:0016529,GO:0018916,GO:0019899,GO:0042178,GO:0042803,GO:0043295,GO:0043651,GO:0045171,GO:0051122,GO:0055119,GO:0060315,GO:0060316,GO:0070062,GO:0070458,GO:0071313,GO:0098869,GO:1901687" glutathione transferase activity|glutathione peroxidase activity|signaling receptor binding|fatty acid binding|protein binding|cytoplasm|cytosol|glutathione metabolic process|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion|sarcoplasmic reticulum|nitrobenzene metabolic process|enzyme binding|xenobiotic catabolic process|protein homodimerization activity|glutathione binding|linoleic acid metabolic process|intercellular bridge|hepoxilin biosynthetic process|relaxation of cardiac muscle|negative regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of ryanodine-sensitive calcium-release channel activity|extracellular exosome|cellular detoxification of nitrogen compound|cellular response to caffeine|cellular oxidant detoxification|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTM3 809.1198232 828.1694506 790.0701958 0.953995822 -0.067945147 0.790968438 1 10.72243607 10.05798808 2947 glutathione S-transferase mu 3 "GO:0004364,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006749,GO:0008065,GO:0018916,GO:0019899,GO:0035686,GO:0042178,GO:0042802,GO:0042803,GO:0043295,GO:0043627,GO:0045171,GO:0070062,GO:0070458,GO:1901687" glutathione transferase activity|protein binding|nucleus|cytoplasm|cytosol|glutathione metabolic process|establishment of blood-nerve barrier|nitrobenzene metabolic process|enzyme binding|sperm fibrous sheath|xenobiotic catabolic process|identical protein binding|protein homodimerization activity|glutathione binding|response to estrogen|intercellular bridge|extracellular exosome|cellular detoxification of nitrogen compound|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTM4 296.5097389 315.2454064 277.7740713 0.881135984 -0.182563411 0.568423045 1 7.270556588 6.299147456 2948 glutathione S-transferase mu 4 "GO:0004364,GO:0004464,GO:0005515,GO:0005737,GO:0005829,GO:0006749,GO:0018916,GO:0019899,GO:0042178,GO:0042759,GO:0042803,GO:0043295,GO:0045171,GO:1901687" glutathione transferase activity|leukotriene-C4 synthase activity|protein binding|cytoplasm|cytosol|glutathione metabolic process|nitrobenzene metabolic process|enzyme binding|xenobiotic catabolic process|long-chain fatty acid biosynthetic process|protein homodimerization activity|glutathione binding|intercellular bridge|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTO1 7616.840426 6262.25116 8971.429693 1.432620549 0.518656541 0.035211354 0.95006405 293.1621358 412.9621344 9446 glutathione S-transferase omega 1 "GO:0004364,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006749,GO:0010880,GO:0010881,GO:0014810,GO:0016491,GO:0019852,GO:0032259,GO:0035722,GO:0042178,GO:0045174,GO:0050610,GO:0055114,GO:0060315,GO:0060316,GO:0070062,GO:0071243,GO:0098869,GO:1901687" glutathione transferase activity|protein binding|nucleoplasm|cytoplasm|cytosol|glutathione metabolic process|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion|oxidoreductase activity|L-ascorbic acid metabolic process|methylation|interleukin-12-mediated signaling pathway|xenobiotic catabolic process|glutathione dehydrogenase (ascorbate) activity|methylarsonate reductase activity|oxidation-reduction process|negative regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of ryanodine-sensitive calcium-release channel activity|extracellular exosome|cellular response to arsenic-containing substance|cellular oxidant detoxification|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTO2 142.7901813 152.9408407 132.6395219 0.867260316 -0.205462998 0.628778967 1 0.80257341 0.684392781 119391 glutathione S-transferase omega 2 "GO:0004364,GO:0005515,GO:0005829,GO:0006749,GO:0006805,GO:0016491,GO:0019852,GO:0042802,GO:0045174,GO:0050610,GO:0055114,GO:0070062,GO:0071243,GO:0098869,GO:1901687" glutathione transferase activity|protein binding|cytosol|glutathione metabolic process|xenobiotic metabolic process|oxidoreductase activity|L-ascorbic acid metabolic process|identical protein binding|glutathione dehydrogenase (ascorbate) activity|methylarsonate reductase activity|oxidation-reduction process|extracellular exosome|cellular response to arsenic-containing substance|cellular oxidant detoxification|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTP1 5422.840753 5072.017678 5773.663828 1.138336692 0.186927335 0.437931188 1 365.2958995 408.8713786 2950 glutathione S-transferase pi 1 "GO:0000302,GO:0002674,GO:0004364,GO:0004602,GO:0005504,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006469,GO:0006693,GO:0006749,GO:0006805,GO:0007417,GO:0008144,GO:0008432,GO:0009890,GO:0010804,GO:0014003,GO:0019207,GO:0031100,GO:0031982,GO:0032355,GO:0032691,GO:0032720,GO:0032869,GO:0032872,GO:0032873,GO:0032930,GO:0033591,GO:0034599,GO:0034774,GO:0035726,GO:0035730,GO:0035731,GO:0035732,GO:0043066,GO:0043124,GO:0043200,GO:0043295,GO:0043312,GO:0043407,GO:0043409,GO:0043508,GO:0043651,GO:0045471,GO:0048147,GO:0051122,GO:0051771,GO:0070026,GO:0070062,GO:0070372,GO:0070373,GO:0070664,GO:0071222,GO:0071364,GO:0071385,GO:0071460,GO:0071638,GO:0071672,GO:0097057,GO:0098869,GO:1901687,GO:1904706,GO:1904813,GO:2001237" response to reactive oxygen species|negative regulation of acute inflammatory response|glutathione transferase activity|glutathione peroxidase activity|fatty acid binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|mitochondrion|cytosol|plasma membrane|negative regulation of protein kinase activity|prostaglandin metabolic process|glutathione metabolic process|xenobiotic metabolic process|central nervous system development|drug binding|JUN kinase binding|negative regulation of biosynthetic process|negative regulation of tumor necrosis factor-mediated signaling pathway|oligodendrocyte development|kinase regulator activity|animal organ regeneration|vesicle|response to estradiol|negative regulation of interleukin-1 beta production|negative regulation of tumor necrosis factor production|cellular response to insulin stimulus|regulation of stress-activated MAPK cascade|negative regulation of stress-activated MAPK cascade|positive regulation of superoxide anion generation|response to L-ascorbic acid|cellular response to oxidative stress|secretory granule lumen|common myeloid progenitor cell proliferation|S-nitrosoglutathione binding|dinitrosyl-iron complex binding|nitric oxide storage|negative regulation of apoptotic process|negative regulation of I-kappaB kinase/NF-kappaB signaling|response to amino acid|glutathione binding|neutrophil degranulation|negative regulation of MAP kinase activity|negative regulation of MAPK cascade|negative regulation of JUN kinase activity|linoleic acid metabolic process|response to ethanol|negative regulation of fibroblast proliferation|hepoxilin biosynthetic process|negative regulation of nitric-oxide synthase biosynthetic process|nitric oxide binding|extracellular exosome|regulation of ERK1 and ERK2 cascade|negative regulation of ERK1 and ERK2 cascade|negative regulation of leukocyte proliferation|cellular response to lipopolysaccharide|cellular response to epidermal growth factor stimulus|cellular response to glucocorticoid stimulus|cellular response to cell-matrix adhesion|negative regulation of monocyte chemotactic protein-1 production|negative regulation of smooth muscle cell chemotaxis|TRAF2-GSTP1 complex|cellular oxidant detoxification|glutathione derivative biosynthetic process|negative regulation of vascular associated smooth muscle cell proliferation|ficolin-1-rich granule lumen|negative regulation of extrinsic apoptotic signaling pathway "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05215,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Prostate cancer|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTT2B 221.5747872 227.8506403 215.2989341 0.94491257 -0.081747247 0.826840499 1 10.97470208 10.1966038 653689 glutathione S-transferase theta 2B "GO:0004364,GO:0005654,GO:0005737,GO:0005829,GO:0006749,GO:0070062,GO:1901687" glutathione transferase activity|nucleoplasm|cytoplasm|cytosol|glutathione metabolic process|extracellular exosome|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTZ1 192.6017144 173.7491184 211.4543103 1.2170094 0.283340311 0.446922648 1 3.115816906 3.728524839 2954 glutathione S-transferase zeta 1 "GO:0004364,GO:0004602,GO:0005515,GO:0005739,GO:0005759,GO:0005829,GO:0006559,GO:0006572,GO:0006749,GO:0010510,GO:0016034,GO:0042802,GO:0042803,GO:0098869,GO:1901687" glutathione transferase activity|glutathione peroxidase activity|protein binding|mitochondrion|mitochondrial matrix|cytosol|L-phenylalanine catabolic process|tyrosine catabolic process|glutathione metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|maleylacetoacetate isomerase activity|identical protein binding|protein homodimerization activity|cellular oxidant detoxification|glutathione derivative biosynthetic process hsa00350 Tyrosine metabolism GSX2 10.92937619 9.363724944 12.49502743 1.334407781 0.416199607 0.772652545 1 0.298699815 0.391917538 170825 GS homeobox 2 "GO:0000785,GO:0000981,GO:0002087,GO:0005634,GO:0005737,GO:0006357,GO:0021527,GO:0021575,GO:0021798,GO:0021889,GO:0021978,GO:0030334,GO:0045747,GO:0048665,GO:0048714,GO:0048853,GO:0060163,GO:1990837" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|regulation of respiratory gaseous exchange by nervous system process|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|spinal cord association neuron differentiation|hindbrain morphogenesis|forebrain dorsal/ventral pattern formation|olfactory bulb interneuron differentiation|telencephalon regionalization|regulation of cell migration|positive regulation of Notch signaling pathway|neuron fate specification|positive regulation of oligodendrocyte differentiation|forebrain morphogenesis|subpallium neuron fate commitment|sequence-specific double-stranded DNA binding" GTDC1 164.3665005 176.87036 151.862641 0.858609894 -0.219925298 0.582579517 1 0.50388331 0.425399564 79712 glycosyltransferase like domain containing 1 GTF2A1 1524.83514 1487.791852 1561.878428 1.049796332 0.070109461 0.770907889 1 11.93457338 12.31921766 2957 general transcription factor IIA subunit 1 "GO:0000979,GO:0001103,GO:0003677,GO:0005515,GO:0005654,GO:0005669,GO:0005672,GO:0005829,GO:0006366,GO:0006367,GO:0008134,GO:0016251,GO:0017025,GO:0042795,GO:0046982,GO:0097550" RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II repressing transcription factor binding|DNA binding|protein binding|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIA complex|cytosol|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription factor binding|RNA polymerase II general transcription initiation factor activity|TBP-class protein binding|snRNA transcription by RNA polymerase II|protein heterodimerization activity|transcription preinitiation complex "hsa03022,hsa05203" Basal transcription factors|Viral carcinogenesis GTF2A2 656.5004302 619.0462602 693.9546002 1.121006046 0.164794059 0.526846815 1 16.8557965 18.57926002 2958 general transcription factor IIA subunit 2 "GO:0001103,GO:0005515,GO:0005654,GO:0005669,GO:0005672,GO:0006366,GO:0006367,GO:0008134,GO:0016032,GO:0016251,GO:0017025,GO:0030054,GO:0042795,GO:0042803,GO:0045944,GO:0046982,GO:0051123" RNA polymerase II repressing transcription factor binding|protein binding|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIA complex|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription factor binding|viral process|RNA polymerase II general transcription initiation factor activity|TBP-class protein binding|cell junction|snRNA transcription by RNA polymerase II|protein homodimerization activity|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|RNA polymerase II preinitiation complex assembly "hsa03022,hsa05203" Basal transcription factors|Viral carcinogenesis GTF2B 683.1649624 637.7737101 728.5562146 1.142342814 0.191995665 0.457186497 1 17.57192087 19.73726043 2959 general transcription factor IIB "GO:0000979,GO:0000993,GO:0001174,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0005694,GO:0006352,GO:0006366,GO:0006367,GO:0006473,GO:0008134,GO:0008270,GO:0016251,GO:0016407,GO:0016573,GO:0016604,GO:0017025,GO:0019083,GO:0032993,GO:0042795,GO:0046966,GO:0051123,GO:0090575,GO:0097550,GO:1904798,GO:1990114,GO:1990841" "RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II complex binding|transcriptional start site selection at RNA polymerase II promoter|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|chromosome|DNA-templated transcription, initiation|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|protein acetylation|transcription factor binding|zinc ion binding|RNA polymerase II general transcription initiation factor activity|acetyltransferase activity|histone acetylation|nuclear body|TBP-class protein binding|viral transcription|protein-DNA complex|snRNA transcription by RNA polymerase II|thyroid hormone receptor binding|RNA polymerase II preinitiation complex assembly|RNA polymerase II transcription regulator complex|transcription preinitiation complex|positive regulation of core promoter binding|RNA polymerase II core complex assembly|promoter-specific chromatin binding" "hsa03022,hsa05017,hsa05203" Basal transcription factors|Spinocerebellar ataxia|Viral carcinogenesis other GTF2E1 465.9694828 474.4287305 457.5102351 0.964339227 -0.052387361 0.857831829 1 8.439796461 8.002634548 2960 general transcription factor IIE subunit 1 "GO:0001113,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0005673,GO:0005829,GO:0006366,GO:0006367,GO:0016032,GO:0016251,GO:0042795,GO:0046872,GO:0097550" transcription open complex formation at RNA polymerase II promoter|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIE complex|cytosol|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|viral process|RNA polymerase II general transcription initiation factor activity|snRNA transcription by RNA polymerase II|metal ion binding|transcription preinitiation complex "hsa03022,hsa05203" Basal transcription factors|Viral carcinogenesis GTF2E2 984.0841914 942.6149777 1025.553405 1.087987598 0.121662111 0.623503747 1 17.08750982 18.27990357 2961 general transcription factor IIE subunit 2 "GO:0003677,GO:0003723,GO:0005515,GO:0005654,GO:0005669,GO:0005673,GO:0005829,GO:0006366,GO:0006367,GO:0016251,GO:0016607,GO:0042795" DNA binding|RNA binding|protein binding|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIE complex|cytosol|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|RNA polymerase II general transcription initiation factor activity|nuclear speck|snRNA transcription by RNA polymerase II "hsa03022,hsa05203" Basal transcription factors|Viral carcinogenesis GTF2F1 1749.204077 1738.531598 1759.876555 1.012277578 0.017604948 0.943424852 1 38.10358772 37.92596723 2962 general transcription factor IIF subunit 1 "GO:0000398,GO:0001096,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0005674,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008134,GO:0008543,GO:0009615,GO:0016070,GO:0016251,GO:0019211,GO:0019903,GO:0019904,GO:0030054,GO:0032091,GO:0032968,GO:0032991,GO:0042795,GO:0043231,GO:0045944,GO:0050434,GO:0050790,GO:1990841" "mRNA splicing, via spliceosome|TFIIF-class transcription factor complex binding|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIF complex|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|transcription factor binding|fibroblast growth factor receptor signaling pathway|response to virus|RNA metabolic process|RNA polymerase II general transcription initiation factor activity|phosphatase activator activity|protein phosphatase binding|protein domain specific binding|cell junction|negative regulation of protein binding|positive regulation of transcription elongation from RNA polymerase II promoter|protein-containing complex|snRNA transcription by RNA polymerase II|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|positive regulation of viral transcription|regulation of catalytic activity|promoter-specific chromatin binding" hsa03022 Basal transcription factors GTF2F2 1378.146844 1169.425204 1586.868483 1.356964497 0.440382975 0.066332868 1 12.80732071 17.08826414 2963 general transcription factor IIF subunit 2 "GO:0000398,GO:0003677,GO:0003678,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005674,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0015630,GO:0016070,GO:0016251,GO:0032508,GO:0042795,GO:0050434,GO:0097550" "mRNA splicing, via spliceosome|DNA binding|DNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|transcription factor TFIIF complex|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|microtubule cytoskeleton|RNA metabolic process|RNA polymerase II general transcription initiation factor activity|DNA duplex unwinding|snRNA transcription by RNA polymerase II|positive regulation of viral transcription|transcription preinitiation complex" hsa03022 Basal transcription factors GTF2H1 923.0898027 1044.575538 801.6040673 0.767396936 -0.38195509 0.122949156 1 16.97535829 12.80885145 2965 general transcription factor IIH subunit 1 "GO:0000079,GO:0000439,GO:0000717,GO:0003682,GO:0005515,GO:0005654,GO:0005675,GO:0006281,GO:0006283,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006360,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0009755,GO:0033683,GO:0045893,GO:0046966,GO:0070816,GO:0070911" "regulation of cyclin-dependent protein serine/threonine kinase activity|transcription factor TFIIH core complex|nucleotide-excision repair, DNA duplex unwinding|chromatin binding|protein binding|nucleoplasm|transcription factor TFIIH holo complex|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|transcription by RNA polymerase I|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|hormone-mediated signaling pathway|nucleotide-excision repair, DNA incision|positive regulation of transcription, DNA-templated|thyroid hormone receptor binding|phosphorylation of RNA polymerase II C-terminal domain|global genome nucleotide-excision repair" "hsa03022,hsa03420,hsa05203" Basal transcription factors|Nucleotide excision repair|Viral carcinogenesis GTF2H2 251.880768 253.8609874 249.9005486 0.984399183 -0.022684634 0.958891648 1 4.852469312 4.696834102 2966 general transcription factor IIH subunit 2 "GO:0000438,GO:0000439,GO:0000717,GO:0002031,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0005675,GO:0006283,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006357,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008270,GO:0009411,GO:0016032,GO:0016251,GO:0016607,GO:0033683,GO:0047485,GO:0070911,GO:1905776" "core TFIIH complex portion of holo TFIIH complex|transcription factor TFIIH core complex|nucleotide-excision repair, DNA duplex unwinding|G protein-coupled receptor internalization|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIH holo complex|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|zinc ion binding|response to UV|viral process|RNA polymerase II general transcription initiation factor activity|nuclear speck|nucleotide-excision repair, DNA incision|protein N-terminus binding|global genome nucleotide-excision repair|positive regulation of DNA helicase activity" "hsa03022,hsa03420,hsa05203" Basal transcription factors|Nucleotide excision repair|Viral carcinogenesis GTF2H2C 259.470636 301.720026 217.2212461 0.719943084 -0.474045238 0.15170312 1 8.629283627 6.108633737 728340 GTF2H2 family member C "GO:0000439,GO:0005515,GO:0005675,GO:0006289,GO:0006351,GO:0006357,GO:0008270,GO:0016607" "transcription factor TFIIH core complex|protein binding|transcription factor TFIIH holo complex|nucleotide-excision repair|transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding|nuclear speck" "hsa03022,hsa03420,hsa05203" Basal transcription factors|Nucleotide excision repair|Viral carcinogenesis GTF2H3 1044.027491 964.4636692 1123.591313 1.164990811 0.220318576 0.369045077 1 23.24826261 26.63079805 2967 general transcription factor IIH subunit 3 "GO:0000438,GO:0000439,GO:0000717,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0005675,GO:0006281,GO:0006283,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0016251,GO:0033683,GO:0046872,GO:0047485,GO:0070816,GO:0070911,GO:0097550" "core TFIIH complex portion of holo TFIIH complex|transcription factor TFIIH core complex|nucleotide-excision repair, DNA duplex unwinding|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIH holo complex|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|RNA polymerase II general transcription initiation factor activity|nucleotide-excision repair, DNA incision|metal ion binding|protein N-terminus binding|phosphorylation of RNA polymerase II C-terminal domain|global genome nucleotide-excision repair|transcription preinitiation complex" "hsa03022,hsa03420,hsa05203" Basal transcription factors|Nucleotide excision repair|Viral carcinogenesis GTF2H4 457.2844806 460.90335 453.6656112 0.984296624 -0.022834949 0.943239078 1 14.36773638 13.90546528 2968 general transcription factor IIH subunit 4 "GO:0000438,GO:0000439,GO:0000717,GO:0001671,GO:0003690,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0005675,GO:0006281,GO:0006283,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0016251,GO:0016607,GO:0032781,GO:0033683,GO:0070816,GO:0070911" "core TFIIH complex portion of holo TFIIH complex|transcription factor TFIIH core complex|nucleotide-excision repair, DNA duplex unwinding|ATPase activator activity|double-stranded DNA binding|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIH holo complex|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|RNA polymerase II general transcription initiation factor activity|nuclear speck|positive regulation of ATPase activity|nucleotide-excision repair, DNA incision|phosphorylation of RNA polymerase II C-terminal domain|global genome nucleotide-excision repair" "hsa03022,hsa03420,hsa05203" Basal transcription factors|Nucleotide excision repair|Viral carcinogenesis GTF2H5 448.738487 400.5593448 496.9176292 1.240559322 0.310990725 0.268537588 1 2.84383611 3.468911974 404672 general transcription factor IIH subunit 5 "GO:0000439,GO:0000462,GO:0000717,GO:0005515,GO:0005654,GO:0005669,GO:0005675,GO:0005730,GO:0006283,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0033683,GO:0070816,GO:0070911,GO:0071480" "transcription factor TFIIH core complex|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nucleotide-excision repair, DNA duplex unwinding|protein binding|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIH holo complex|nucleolus|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|nucleotide-excision repair, DNA incision|phosphorylation of RNA polymerase II C-terminal domain|global genome nucleotide-excision repair|cellular response to gamma radiation" "hsa03022,hsa03420" Basal transcription factors|Nucleotide excision repair GTF2I 1301.728072 1484.670611 1118.785533 0.753558079 -0.408209386 0.089785121 1 17.10951021 12.67726258 2969 general transcription factor IIi "GO:0000981,GO:0001102,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0016020,GO:0016525,GO:0045944,GO:0100026" "DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II activating transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|membrane|negative regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|positive regulation of DNA repair by transcription from RNA polymerase II promoter" "hsa03022,hsa04022" Basal transcription factors|cGMP-PKG signaling pathway other GTF2IRD1 839.5792894 870.8264198 808.332159 0.928235686 -0.107436932 0.670660244 1 8.961512825 8.179198912 9569 GTF2I repeat domain containing 1 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006366,GO:0007275,GO:0014886" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|transcription by RNA polymerase II|multicellular organism development|transition between slow and fast fiber" "hsa03022,hsa04022" Basal transcription factors|cGMP-PKG signaling pathway GTF2IRD2 25.69834578 31.21241648 20.18427508 0.64667454 -0.628888283 0.428229942 1 0.294301997 0.187132901 84163 GTF2I repeat domain containing 2 "GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II" GTF2IRD2B 98.91416074 111.3242854 86.50403604 0.777045509 -0.363929 0.444824106 1 1.2963501 0.990466837 389524 GTF2I repeat domain containing 2B "GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006357" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II" GTF3A 1839.349561 1745.814495 1932.884628 1.107153499 0.146855256 0.536314147 1 64.56750584 70.2899163 2971 general transcription factor IIIA "GO:0003677,GO:0005634,GO:0005654,GO:0006383,GO:0008097,GO:0009303,GO:0042273,GO:0046872" DNA binding|nucleus|nucleoplasm|transcription by RNA polymerase III|5S rRNA binding|rRNA transcription|ribosomal large subunit biogenesis|metal ion binding zf-C2H2 GTF3C1 3141.126708 3307.475733 2974.777684 0.899410283 -0.152948717 0.518854315 1 24.89617785 22.0171806 2975 general transcription factor IIIC subunit 1 "GO:0000127,GO:0003677,GO:0005515,GO:0005654,GO:0005730,GO:0006383,GO:0006384,GO:0009303,GO:0009304,GO:0016020,GO:0042791,GO:0042797,GO:1990904" transcription factor TFIIIC complex|DNA binding|protein binding|nucleoplasm|nucleolus|transcription by RNA polymerase III|transcription initiation from RNA polymerase III promoter|rRNA transcription|tRNA transcription|membrane|5S class rRNA transcription by RNA polymerase III|tRNA transcription by RNA polymerase III|ribonucleoprotein complex other GTF3C2 1180.241837 1335.891425 1024.592249 0.766972697 -0.382752874 0.114317752 1 17.71281245 13.35791288 2976 general transcription factor IIIC subunit 2 "GO:0000127,GO:0003677,GO:0005515,GO:0005654,GO:0006383,GO:0042791,GO:0042797" transcription factor TFIIIC complex|DNA binding|protein binding|nucleoplasm|transcription by RNA polymerase III|5S class rRNA transcription by RNA polymerase III|tRNA transcription by RNA polymerase III other GTF3C3 1661.40799 1565.822893 1756.993088 1.122089283 0.166187473 0.485153885 1 17.31201366 19.10056347 9330 general transcription factor IIIC subunit 3 "GO:0000127,GO:0003677,GO:0005515,GO:0005654,GO:0005730,GO:0006383,GO:0031965,GO:0042791,GO:0042797" transcription factor TFIIIC complex|DNA binding|protein binding|nucleoplasm|nucleolus|transcription by RNA polymerase III|nuclear membrane|5S class rRNA transcription by RNA polymerase III|tRNA transcription by RNA polymerase III GTF3C4 1001.577499 1061.22216 941.9328369 0.887592506 -0.172030608 0.48530586 1 8.270367443 7.217879222 9329 general transcription factor IIIC subunit 4 "GO:0000127,GO:0003677,GO:0004402,GO:0005515,GO:0005654,GO:0005739,GO:0006383,GO:0006384,GO:0008047,GO:0016573,GO:0042791,GO:0042797,GO:0050790" transcription factor TFIIIC complex|DNA binding|histone acetyltransferase activity|protein binding|nucleoplasm|mitochondrion|transcription by RNA polymerase III|transcription initiation from RNA polymerase III promoter|enzyme activator activity|histone acetylation|5S class rRNA transcription by RNA polymerase III|tRNA transcription by RNA polymerase III|regulation of catalytic activity GTF3C5 1464.208088 1473.226058 1455.190117 0.98775752 -0.01777117 0.943753886 1 33.64286137 32.67491372 9328 general transcription factor IIIC subunit 5 "GO:0000127,GO:0003677,GO:0005515,GO:0005654,GO:0006383,GO:0006384,GO:0035914,GO:0042791,GO:0042797" transcription factor TFIIIC complex|DNA binding|protein binding|nucleoplasm|transcription by RNA polymerase III|transcription initiation from RNA polymerase III promoter|skeletal muscle cell differentiation|5S class rRNA transcription by RNA polymerase III|tRNA transcription by RNA polymerase III other GTF3C6 234.3522478 222.6485709 246.0559247 1.10513139 0.144217904 0.682465594 1 15.07911804 16.38555041 112495 general transcription factor IIIC subunit 6 "GO:0000127,GO:0003677,GO:0005515,GO:0005654,GO:0006383,GO:0016604,GO:0042791,GO:0042797" transcription factor TFIIIC complex|DNA binding|protein binding|nucleoplasm|transcription by RNA polymerase III|nuclear body|5S class rRNA transcription by RNA polymerase III|tRNA transcription by RNA polymerase III GTPBP1 1109.686808 1212.082173 1007.291442 0.831042205 -0.267006348 0.273308803 1 15.22037597 12.43711469 9567 GTP binding protein 1 "GO:0000177,GO:0003723,GO:0003746,GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0006414,GO:0006955,GO:0007165,GO:0016020,GO:0046039,GO:0061014" cytoplasmic exosome (RNase complex)|RNA binding|translation elongation factor activity|GTPase activity|protein binding|GTP binding|cytosol|translational elongation|immune response|signal transduction|membrane|GTP metabolic process|positive regulation of mRNA catabolic process GTPBP10 700.1581843 705.4006124 694.9157562 0.98513631 -0.021604736 0.938739136 1 5.02683058 4.869246417 85865 GTP binding protein 10 "GO:0003723,GO:0003924,GO:0005515,GO:0005525,GO:0005694,GO:0005730,GO:0005739,GO:0042254" RNA binding|GTPase activity|protein binding|GTP binding|chromosome|nucleolus|mitochondrion|ribosome biogenesis GTPBP2 1771.571746 1985.109688 1558.033805 0.78486031 -0.34949219 0.140606561 1 29.25756851 22.57884783 54676 GTP binding protein 2 "GO:0002576,GO:0003746,GO:0003924,GO:0005515,GO:0005525,GO:0005576,GO:0006414,GO:0008150,GO:0031093,GO:0042802" platelet degranulation|translation elongation factor activity|GTPase activity|protein binding|GTP binding|extracellular region|translational elongation|biological_process|platelet alpha granule lumen|identical protein binding GTPBP3 425.5518572 397.4381032 453.6656112 1.14147488 0.190899111 0.505552031 1 7.835441857 8.794294996 84705 "GTP binding protein 3, mitochondrial" "GO:0002098,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005739,GO:0030488" tRNA wobble uridine modification|GTPase activity|protein binding|GTP binding|cytoplasm|mitochondrion|tRNA methylation GTPBP4 1645.702403 1582.469515 1708.93529 1.079916721 0.110920061 0.642227293 1 32.46962306 34.47773213 23560 GTP binding protein 4 "GO:0000079,GO:0000463,GO:0001649,GO:0003723,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0008156,GO:0008285,GO:0016020,GO:0022408,GO:0030336,GO:0031397,GO:0031965,GO:0033342,GO:0048471,GO:0050821" "regulation of cyclin-dependent protein serine/threonine kinase activity|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|osteoblast differentiation|RNA binding|GTPase activity|protein binding|GTP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|negative regulation of DNA replication|negative regulation of cell population proliferation|membrane|negative regulation of cell-cell adhesion|negative regulation of cell migration|negative regulation of protein ubiquitination|nuclear membrane|negative regulation of collagen binding|perinuclear region of cytoplasm|protein stabilization" hsa03008 Ribosome biogenesis in eukaryotes GTPBP6-2 17.05297259 18.72744989 15.3784953 0.821174019 -0.284240111 0.809190529 1 0.274951742 0.22200505 8225 GTP binding protein 6 (putative) GTPBP8 166.5316167 170.6278768 162.4353566 0.951986039 -0.070987678 0.870421324 1 4.740289527 4.437175705 29083 GTP binding protein 8 (putative) "GO:0005515,GO:0005525,GO:0005739,GO:0046872" protein binding|GTP binding|mitochondrion|metal ion binding GTSE1 2157.202262 2167.182118 2147.222406 0.990790016 -0.013348763 0.957094819 1 19.99628743 19.48059292 51512 G2 and S-phase expressed 1 "GO:0003674,GO:0005515,GO:0005654,GO:0005829,GO:0005881,GO:0006977,GO:0007017,GO:0008017,GO:0015630,GO:0016020,GO:0030335,GO:0046827,GO:0050821,GO:1900182,GO:1902749" "molecular_function|protein binding|nucleoplasm|cytosol|cytoplasmic microtubule|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|microtubule-based process|microtubule binding|microtubule cytoskeleton|membrane|positive regulation of cell migration|positive regulation of protein export from nucleus|protein stabilization|positive regulation of protein localization to nucleus|regulation of cell cycle G2/M phase transition" hsa04115 p53 signaling pathway GUCA1B 16.53276565 17.687036 15.3784953 0.869478373 -0.201777951 0.890777234 1 0.415825817 0.355501479 2979 guanylate cyclase activator 1B "GO:0001917,GO:0005509,GO:0005515,GO:0005886,GO:0007168,GO:0007267,GO:0007589,GO:0007601,GO:0008048,GO:0022400,GO:0031284,GO:0097381,GO:0120199" photoreceptor inner segment|calcium ion binding|protein binding|plasma membrane|receptor guanylyl cyclase signaling pathway|cell-cell signaling|body fluid secretion|visual perception|calcium sensitive guanylate cyclase activator activity|regulation of rhodopsin mediated signaling pathway|positive regulation of guanylate cyclase activity|photoreceptor disc membrane|cone photoreceptor outer segment hsa04744 Phototransduction GUCD1 1758.057655 1731.248701 1784.86661 1.030970657 0.044003272 0.855057581 1 24.85033923 25.19125505 83606 guanylyl cyclase domain containing 1 GO:0005515 protein binding GUCY1A1 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.017151455 0 2982 guanylate cyclase 1 soluble subunit alpha 1 "GO:0004383,GO:0005515,GO:0005525,GO:0006182,GO:0007263,GO:0008015,GO:0008074,GO:0008217,GO:0010750,GO:0020037,GO:0038023,GO:0060087,GO:0098925,GO:0098978,GO:0098982" "guanylate cyclase activity|protein binding|GTP binding|cGMP biosynthetic process|nitric oxide mediated signal transduction|blood circulation|guanylate cyclase complex, soluble|regulation of blood pressure|positive regulation of nitric oxide mediated signal transduction|heme binding|signaling receptor activity|relaxation of vascular associated smooth muscle|retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission|glutamatergic synapse|GABA-ergic synapse" "hsa00230,hsa04022,hsa04270,hsa04540,hsa04611,hsa04713,hsa04730,hsa04921,hsa04924,hsa04970" Purine metabolism|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Gap junction|Platelet activation|Circadian entrainment|Long-term depression|Oxytocin signaling pathway|Renin secretion|Salivary secretion GUCY1A2 2.561405743 4.161655531 0.961155956 0.230955193 -2.11431511 0.482263142 1 0.013673577 0.003105139 2977 guanylate cyclase 1 soluble subunit alpha 2 "GO:0004383,GO:0005515,GO:0005525,GO:0005737,GO:0006182,GO:0007165,GO:0010750,GO:0020037,GO:0035556,GO:0044877" guanylate cyclase activity|protein binding|GTP binding|cytoplasm|cGMP biosynthetic process|signal transduction|positive regulation of nitric oxide mediated signal transduction|heme binding|intracellular signal transduction|protein-containing complex binding "hsa00230,hsa04022,hsa04270,hsa04540,hsa04611,hsa04713,hsa04730,hsa04921,hsa04924,hsa04970" Purine metabolism|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Gap junction|Platelet activation|Circadian entrainment|Long-term depression|Oxytocin signaling pathway|Renin secretion|Salivary secretion GUCY2D 2.962725795 2.080827765 3.844623824 1.847641543 0.88568489 0.829811711 1 0.016379049 0.029756208 3000 "guanylate cyclase 2D, retinal" "GO:0001653,GO:0001750,GO:0004383,GO:0004672,GO:0005515,GO:0005524,GO:0005525,GO:0005640,GO:0005789,GO:0005886,GO:0005887,GO:0006182,GO:0006468,GO:0007165,GO:0007168,GO:0007601,GO:0022400,GO:0035556,GO:0038023,GO:0042622,GO:0042803,GO:0097381" peptide receptor activity|photoreceptor outer segment|guanylate cyclase activity|protein kinase activity|protein binding|ATP binding|GTP binding|nuclear outer membrane|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|cGMP biosynthetic process|protein phosphorylation|signal transduction|receptor guanylyl cyclase signaling pathway|visual perception|regulation of rhodopsin mediated signaling pathway|intracellular signal transduction|signaling receptor activity|photoreceptor outer segment membrane|protein homodimerization activity|photoreceptor disc membrane "hsa00230,hsa04740,hsa04744" Purine metabolism|Olfactory transduction|Phototransduction GUF1 964.7616926 990.4740163 939.049369 0.948080771 -0.076918121 0.758401946 1 12.54682598 11.69635096 60558 GTP binding elongation factor GUF1 "GO:0003924,GO:0005525,GO:0005739,GO:0005743,GO:0005759,GO:0006412,GO:0043022,GO:0045727" GTPase activity|GTP binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|translation|ribosome binding|positive regulation of translation GUK1 1690.124397 1461.781505 1918.467288 1.312417267 0.39222648 0.098755387 1 53.76470867 69.380977 2987 guanylate kinase 1 "GO:0001917,GO:0004385,GO:0005515,GO:0005524,GO:0005829,GO:0006163,GO:0006185,GO:0006805,GO:0015949,GO:0016310,GO:0046037,GO:0046710" photoreceptor inner segment|guanylate kinase activity|protein binding|ATP binding|cytosol|purine nucleotide metabolic process|dGDP biosynthetic process|xenobiotic metabolic process|nucleobase-containing small molecule interconversion|phosphorylation|GMP metabolic process|GDP metabolic process hsa00230 Purine metabolism GULP1 932.598181 903.0792501 962.1171119 1.065373955 0.091359916 0.715074719 1 7.511795479 7.868954042 51454 GULP PTB domain containing engulfment adaptor 1 "GO:0005737,GO:0006869,GO:0006911,GO:0006915" "cytoplasm|lipid transport|phagocytosis, engulfment|apoptotic process" GUSB 893.4090533 858.3414532 928.4766535 1.08171014 0.11331396 0.651193947 1 20.88832913 22.21701874 2990 glucuronidase beta "GO:0004566,GO:0005102,GO:0005576,GO:0005615,GO:0005975,GO:0006027,GO:0016020,GO:0019391,GO:0019904,GO:0030214,GO:0030246,GO:0035578,GO:0043202,GO:0043231,GO:0043312,GO:0070062,GO:1904813" beta-glucuronidase activity|signaling receptor binding|extracellular region|extracellular space|carbohydrate metabolic process|glycosaminoglycan catabolic process|membrane|glucuronoside catabolic process|protein domain specific binding|hyaluronan catabolic process|carbohydrate binding|azurophil granule lumen|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|extracellular exosome|ficolin-1-rich granule lumen "hsa00040,hsa00053,hsa00531,hsa00860,hsa00983,hsa04142" Pentose and glucuronate interconversions|Ascorbate and aldarate metabolism|Glycosaminoglycan degradation|Porphyrin and chlorophyll metabolism|Drug metabolism - other enzymes|Lysosome GVQW3 378.3017299 380.791481 375.8119788 0.986923283 -0.018990151 0.958304219 1 1.129635435 1.096207782 100506127 GVQW motif containing 3 GXYLT1 596.1853788 625.2887435 567.082014 0.906912238 -0.140965146 0.59571418 1 4.346816596 3.876214106 283464 glucoside xylosyltransferase 1 "GO:0016021,GO:0016266,GO:0035252,GO:0140563" "integral component of membrane|O-glycan processing|UDP-xylosyltransferase activity|UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity" hsa00514 Other types of O-glycan biosynthesis GXYLT2 172.2589234 169.5874629 174.930384 1.031505402 0.044751376 0.923304799 1 2.527386541 2.56338804 727936 glucoside xylosyltransferase 2 "GO:0016021,GO:0016266,GO:0035252,GO:0140563" "integral component of membrane|O-glycan processing|UDP-xylosyltransferase activity|UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity" hsa00514 Other types of O-glycan biosynthesis GYG1 687.504641 701.2389569 673.7703252 0.960828429 -0.057649257 0.827535091 1 13.06698125 12.34503402 2992 glycogenin 1 "GO:0005515,GO:0005576,GO:0005829,GO:0005978,GO:0008466,GO:0016020,GO:0016757,GO:0030145,GO:0034774,GO:0042803,GO:0043202,GO:0043312,GO:0102751,GO:1904813" "protein binding|extracellular region|cytosol|glycogen biosynthetic process|glycogenin glucosyltransferase activity|membrane|transferase activity, transferring glycosyl groups|manganese ion binding|secretory granule lumen|protein homodimerization activity|lysosomal lumen|neutrophil degranulation|UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity|ficolin-1-rich granule lumen" hsa00500 Starch and sucrose metabolism GYS1 1036.640184 1010.24188 1063.038487 1.052261353 0.073493075 0.767376458 1 15.10640302 15.62988799 2997 glycogen synthase 1 "GO:0004373,GO:0005515,GO:0005536,GO:0005737,GO:0005829,GO:0005978,GO:0007507,GO:0016020,GO:0016234,GO:0019901,GO:0061547" "glycogen (starch) synthase activity|protein binding|glucose binding|cytoplasm|cytosol|glycogen biosynthetic process|heart development|membrane|inclusion body|protein kinase binding|glycogen synthase activity, transferring glucose-1-phosphate" "hsa00500,hsa04151,hsa04152,hsa04910,hsa04922,hsa04931" Starch and sucrose metabolism|PI3K-Akt signaling pathway|AMPK signaling pathway|Insulin signaling pathway|Glucagon signaling pathway|Insulin resistance GZF1 592.9452502 615.9250185 569.9654819 0.92538128 -0.111880181 0.675399347 1 5.845773825 5.319047841 64412 GDNF inducible zinc finger protein 1 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0001658,GO:0005654,GO:0005730,GO:0005737,GO:0006355,GO:0043565,GO:0045892,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|branching involved in ureteric bud morphogenesis|nucleoplasm|nucleolus|cytoplasm|regulation of transcription, DNA-templated|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding" H1-0 10378.16784 10222.0664 10534.26928 1.030542052 0.043403376 0.863652187 1 247.5194629 250.8108099 3005 H1.0 linker histone "GO:0000122,GO:0000785,GO:0000786,GO:0000791,GO:0003680,GO:0003690,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0006309,GO:0006334,GO:0006342,GO:0015629,GO:0016584,GO:0016604,GO:0017053,GO:0030261,GO:0031490,GO:0031492,GO:0031936,GO:0045910,GO:2000679" negative regulation of transcription by RNA polymerase II|chromatin|nucleosome|euchromatin|minor groove of adenine-thymine-rich DNA binding|double-stranded DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|Golgi apparatus|apoptotic DNA fragmentation|nucleosome assembly|chromatin silencing|actin cytoskeleton|nucleosome positioning|nuclear body|transcription repressor complex|chromosome condensation|chromatin DNA binding|nucleosomal DNA binding|negative regulation of chromatin silencing|negative regulation of DNA recombination|positive regulation of transcription regulatory region DNA binding H1-10 2173.180836 2069.383213 2276.97846 1.10031745 0.137919812 0.560433018 1 72.84906246 78.81577422 8971 H1.10 linker histone "GO:0000786,GO:0003690,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0006334,GO:0016584,GO:0030261,GO:0031492,GO:0031936,GO:0045296,GO:0045910" nucleosome|double-stranded DNA binding|RNA binding|nucleus|nucleoplasm|nucleolus|nucleosome assembly|nucleosome positioning|chromosome condensation|nucleosomal DNA binding|negative regulation of chromatin silencing|cadherin binding|negative regulation of DNA recombination H1-2 44.11379438 47.8590386 40.36855015 0.843488531 -0.245559643 0.721644947 1 3.494047782 2.89787201 3006 "H1.2 linker histone, cluster member" "GO:0000786,GO:0000791,GO:0003690,GO:0003723,GO:0005515,GO:0005634,GO:0006334,GO:0016584,GO:0030261,GO:0031490,GO:0031492,GO:0031936,GO:0045910" nucleosome|euchromatin|double-stranded DNA binding|RNA binding|protein binding|nucleus|nucleosome assembly|nucleosome positioning|chromosome condensation|chromatin DNA binding|nucleosomal DNA binding|negative regulation of chromatin silencing|negative regulation of DNA recombination H1-3 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.214658415 0.064995841 3007 "H1.3 linker histone, cluster member" "GO:0000785,GO:0000786,GO:0000791,GO:0003690,GO:0003723,GO:0005634,GO:0006334,GO:0016584,GO:0030261,GO:0031490,GO:0031492,GO:0031936,GO:0045910" chromatin|nucleosome|euchromatin|double-stranded DNA binding|RNA binding|nucleus|nucleosome assembly|nucleosome positioning|chromosome condensation|chromatin DNA binding|nucleosomal DNA binding|negative regulation of chromatin silencing|negative regulation of DNA recombination H2AB1 5.563760501 7.282897178 3.844623824 0.527897584 -0.921670032 0.614283311 1 0.662137712 0.343691805 474382 H2A.B variant histone 1 "GO:0000786,GO:0003677,GO:0005634,GO:0006334,GO:0006342,GO:0006397,GO:0035327,GO:0046982" nucleosome|DNA binding|nucleus|nucleosome assembly|chromatin silencing|mRNA processing|transcriptionally active chromatin|protein heterodimerization activity "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AC11 5.04355356 6.242483296 3.844623824 0.615880514 -0.699277611 0.760739355 1 0.675760366 0.409223305 8969 H2A clustered histone 11 "GO:0000786,GO:0003677,GO:0005515,GO:0005634,GO:0006342,GO:0008150,GO:0019899,GO:0046982,GO:0070062" nucleosome|DNA binding|protein binding|nucleus|chromatin silencing|biological_process|enzyme binding|protein heterodimerization activity|extracellular exosome "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AC15 3.443303773 2.080827765 4.80577978 2.309551929 1.207612985 0.648665767 1 0.223891035 0.508435205 8330 H2A clustered histone 15 "GO:0000786,GO:0003674,GO:0003677,GO:0005515,GO:0005634,GO:0006342,GO:0008150,GO:0019899,GO:0046982,GO:0070062" nucleosome|molecular_function|DNA binding|protein binding|nucleus|chromatin silencing|biological_process|enzyme binding|protein heterodimerization activity|extracellular exosome "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AC20 3.884252787 1.040413883 6.728091692 6.466745402 2.693039812 0.222326747 1 0.112398738 0.714691106 8338 H2A clustered histone 20 "GO:0000786,GO:0003674,GO:0003677,GO:0005634,GO:0006342,GO:0008150,GO:0046982,GO:0070062" nucleosome|molecular_function|DNA binding|nucleus|chromatin silencing|biological_process|protein heterodimerization activity|extracellular exosome "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AC6 39.50615941 53.06110801 25.95121081 0.489081585 -1.03185295 0.115220628 1 5.456211585 2.623878331 8334 H2A clustered histone 6 "GO:0000786,GO:0003674,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006342,GO:0008285,GO:0046982,GO:0070062" nucleosome|molecular_function|DNA binding|protein binding|nucleus|nucleoplasm|chromatin silencing|negative regulation of cell population proliferation|protein heterodimerization activity|extracellular exosome "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AC8 4.082397604 6.242483296 1.922311912 0.307940257 -1.699277611 0.406294648 1 0.591740427 0.179171483 3012 H2A clustered histone 8 "GO:0000786,GO:0003677,GO:0005515,GO:0005634,GO:0006342,GO:0008285,GO:0046982,GO:0070062" nucleosome|DNA binding|protein binding|nucleus|chromatin silencing|negative regulation of cell population proliferation|protein heterodimerization activity|extracellular exosome "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AJ 733.3677546 681.4710931 785.264416 1.152307741 0.204526062 0.423092103 1 58.65945121 66.46265003 55766 H2A.J histone "GO:0000786,GO:0003674,GO:0003677,GO:0005634,GO:0006342,GO:0008150,GO:0046982,GO:0070062" nucleosome|molecular_function|DNA binding|nucleus|chromatin silencing|biological_process|protein heterodimerization activity|extracellular exosome "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AW 21.01648331 21.84869154 20.18427508 0.923820772 -0.11431511 0.952387338 1 2.286322571 2.076808274 92815 H2A.W histone "GO:0000786,GO:0003677,GO:0005515,GO:0005634,GO:0006337,GO:0006342,GO:0046982,GO:0070062,GO:0070914" nucleosome|DNA binding|protein binding|nucleus|nucleosome disassembly|chromatin silencing|protein heterodimerization activity|extracellular exosome|UV-damage excision repair "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AX 1160.151911 1300.517353 1019.786469 0.784139071 -0.350818549 0.148363688 1 43.59687242 33.61395444 3014 H2A.X variant histone "GO:0000077,GO:0000724,GO:0000781,GO:0000786,GO:0000794,GO:0001673,GO:0001741,GO:0003677,GO:0003684,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0005813,GO:0006302,GO:0006303,GO:0006334,GO:0006342,GO:0006974,GO:0007283,GO:0010212,GO:0016032,GO:0016607,GO:0019899,GO:0021987,GO:0035861,GO:0042393,GO:0045739,GO:0046982,GO:0051321,GO:0070062,GO:0071480,GO:0090398,GO:0090734" "DNA damage checkpoint|double-strand break repair via homologous recombination|chromosome, telomeric region|nucleosome|condensed nuclear chromosome|male germ cell nucleus|XY body|DNA binding|damaged DNA binding|protein binding|nucleus|nucleoplasm|replication fork|centrosome|double-strand break repair|double-strand break repair via nonhomologous end joining|nucleosome assembly|chromatin silencing|cellular response to DNA damage stimulus|spermatogenesis|response to ionizing radiation|viral process|nuclear speck|enzyme binding|cerebral cortex development|site of double-strand break|histone binding|positive regulation of DNA repair|protein heterodimerization activity|meiotic cell cycle|extracellular exosome|cellular response to gamma radiation|cellular senescence|site of DNA damage" "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AZ1 5745.981654 5190.624861 6301.338447 1.213984562 0.279750075 0.247042738 1 319.8777238 381.8284984 3015 H2A.Z variant histone 1 "GO:0000786,GO:0000791,GO:0000792,GO:0000978,GO:0000979,GO:0001740,GO:0003677,GO:0005515,GO:0005634,GO:0006342,GO:0031490,GO:0031492,GO:0045944,GO:0046982,GO:0070062,GO:0071392" nucleosome|euchromatin|heterochromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|Barr body|DNA binding|protein binding|nucleus|chromatin silencing|chromatin DNA binding|nucleosomal DNA binding|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|extracellular exosome|cellular response to estradiol stimulus "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2AZ2 3635.521332 3506.194785 3764.84788 1.073770315 0.102685427 0.666146574 1 29.69674203 31.35388626 94239 H2A.Z variant histone 2 "GO:0000786,GO:0003674,GO:0003677,GO:0005634,GO:0006342,GO:0008150,GO:0046982,GO:0070062" nucleosome|molecular_function|DNA binding|nucleus|chromatin silencing|biological_process|protein heterodimerization activity|extracellular exosome "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus H2BC11 20.41198802 31.21241648 9.61155956 0.307940257 -1.699277611 0.048015507 1 3.470311045 1.050766091 8970 H2B clustered histone 11 "GO:0000786,GO:0001530,GO:0002227,GO:0003677,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006334,GO:0010804,GO:0016567,GO:0019731,GO:0031640,GO:0046982,GO:0050829,GO:0050830,GO:0061844" nucleosome|lipopolysaccharide binding|innate immune response in mucosa|DNA binding|protein binding|extracellular space|nucleus|nucleoplasm|cytosol|plasma membrane|nucleosome assembly|negative regulation of tumor necrosis factor-mediated signaling pathway|protein ubiquitination|antibacterial humoral response|killing of cells of other organism|protein heterodimerization activity|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H2BC12 152.3570815 164.3853935 140.3287696 0.853657169 -0.228271299 0.57959208 1 9.890582098 8.301881358 85236 H2B clustered histone 12 "GO:0000786,GO:0002227,GO:0003674,GO:0003677,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0016567,GO:0019731,GO:0031640,GO:0046982,GO:0050829,GO:0050830,GO:0061844" nucleosome|innate immune response in mucosa|molecular_function|DNA binding|protein binding|extracellular space|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein ubiquitination|antibacterial humoral response|killing of cells of other organism|protein heterodimerization activity|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H2BC15 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.307333819 0.186113551 8341 H2B clustered histone 15 "GO:0000786,GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0016567,GO:0046982,GO:0070062" nucleosome|DNA binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein ubiquitination|protein heterodimerization activity|extracellular exosome "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H2BC21 43.55395847 45.77821084 41.32970611 0.902824845 -0.147481974 0.848695291 1 1.098515726 0.975171408 8349 H2B clustered histone 21 "GO:0000786,GO:0002227,GO:0003677,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0019731,GO:0046982,GO:0050830,GO:0061844,GO:0070062" nucleosome|innate immune response in mucosa|DNA binding|protein binding|extracellular space|nucleus|nucleoplasm|cytosol|nucleosome assembly|antibacterial humoral response|protein heterodimerization activity|defense response to Gram-positive bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide|extracellular exosome "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H2BC4 20.25347217 27.05076095 13.45618338 0.497441954 -1.007399906 0.239354145 1 0.595073947 0.291061341 8347 H2B clustered histone 4 "GO:0000786,GO:0002227,GO:0003677,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0016567,GO:0019731,GO:0042802,GO:0046982,GO:0050830,GO:0061844,GO:0070062" nucleosome|innate immune response in mucosa|DNA binding|protein binding|extracellular space|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein ubiquitination|antibacterial humoral response|identical protein binding|protein heterodimerization activity|defense response to Gram-positive bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide|extracellular exosome "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H2BC5 30.97967312 43.69738307 18.26196316 0.417918921 -1.258705019 0.080530396 1 1.766703805 0.725983845 3017 H2B clustered histone 5 "GO:0000786,GO:0003674,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0016567,GO:0046982,GO:0070062" nucleosome|molecular_function|DNA binding|protein binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein ubiquitination|protein heterodimerization activity|extracellular exosome "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H2BC7 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.319894962 8343 H2B clustered histone 7 "GO:0000786,GO:0002227,GO:0003677,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0016567,GO:0019731,GO:0042802,GO:0046982,GO:0050830,GO:0061844,GO:0070062" nucleosome|innate immune response in mucosa|DNA binding|protein binding|extracellular space|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein ubiquitination|antibacterial humoral response|identical protein binding|protein heterodimerization activity|defense response to Gram-positive bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide|extracellular exosome "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H2BC8 7.68421723 12.48496659 2.883467868 0.230955193 -2.11431511 0.122989943 1 1.362576116 0.309428051 8339 H2B clustered histone 8 "GO:0000786,GO:0002227,GO:0003677,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0016567,GO:0019731,GO:0042802,GO:0046982,GO:0050830,GO:0061844,GO:0070062" nucleosome|innate immune response in mucosa|DNA binding|protein binding|extracellular space|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein ubiquitination|antibacterial humoral response|identical protein binding|protein heterodimerization activity|defense response to Gram-positive bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide|extracellular exosome "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H2BC9 16.45350772 15.60620824 17.30080721 1.108584926 0.148719296 0.942598277 1 1.802758984 1.965069053 8345 H2B clustered histone 9 "GO:0000786,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0016567,GO:0019899,GO:0032991,GO:0044389,GO:0046982,GO:0070062,GO:0097677" nucleosome|DNA binding|protein binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein ubiquitination|enzyme binding|protein-containing complex|ubiquitin-like protein ligase binding|protein heterodimerization activity|extracellular exosome|STAT family protein binding "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H3-2 30.45946618 42.65696919 18.26196316 0.428112065 -1.223939601 0.091198643 1 0.851673792 0.358510541 440686 H3.2 histone (putative) H3-3A 2116.526741 2133.888873 2099.164608 0.983727238 -0.023669745 0.922309625 1 76.32823542 73.82969895 3020 H3.3 histone A "GO:0000183,GO:0000228,GO:0000781,GO:0000786,GO:0000978,GO:0000979,GO:0001649,GO:0001740,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006334,GO:0006336,GO:0006997,GO:0007286,GO:0007338,GO:0007566,GO:0007596,GO:0008283,GO:0008584,GO:0030307,GO:0031492,GO:0031508,GO:0031509,GO:0032200,GO:0032991,GO:0035264,GO:0042692,GO:0044267,GO:0045652,GO:0045814,GO:0046982,GO:0048477,GO:0060964,GO:0070062,GO:0090230,GO:1902340" "rDNA heterochromatin assembly|nuclear chromosome|chromosome, telomeric region|nucleosome|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|osteoblast differentiation|Barr body|protein binding|extracellular region|nucleus|nucleoplasm|nucleosome assembly|DNA replication-independent nucleosome assembly|nucleus organization|spermatid development|single fertilization|embryo implantation|blood coagulation|cell population proliferation|male gonad development|positive regulation of cell growth|nucleosomal DNA binding|pericentric heterochromatin assembly|subtelomeric heterochromatin assembly|telomere organization|protein-containing complex|multicellular organism growth|muscle cell differentiation|cellular protein metabolic process|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|oogenesis|regulation of gene silencing by miRNA|extracellular exosome|regulation of centromere complex assembly|negative regulation of chromosome condensation" "hsa05034,hsa05131,hsa05202,hsa05322" Alcoholism|Shigellosis|Transcriptional misregulation in cancer|Systemic lupus erythematosus H3-3B 19340.96975 18713.92451 19968.01499 1.067013762 0.093578783 0.730717929 1 369.2154367 387.3655992 3021 H3.3 histone B "GO:0000183,GO:0000228,GO:0000781,GO:0000786,GO:0000978,GO:0000979,GO:0001649,GO:0001740,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006334,GO:0006336,GO:0006997,GO:0007286,GO:0007338,GO:0007566,GO:0007596,GO:0008283,GO:0008584,GO:0030307,GO:0031492,GO:0031508,GO:0031509,GO:0032200,GO:0032991,GO:0035264,GO:0042692,GO:0044267,GO:0045652,GO:0045814,GO:0046982,GO:0048477,GO:0060964,GO:0070062,GO:0090230,GO:1902340" "rDNA heterochromatin assembly|nuclear chromosome|chromosome, telomeric region|nucleosome|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|osteoblast differentiation|Barr body|protein binding|extracellular region|nucleus|nucleoplasm|nucleosome assembly|DNA replication-independent nucleosome assembly|nucleus organization|spermatid development|single fertilization|embryo implantation|blood coagulation|cell population proliferation|male gonad development|positive regulation of cell growth|nucleosomal DNA binding|pericentric heterochromatin assembly|subtelomeric heterochromatin assembly|telomere organization|protein-containing complex|multicellular organism growth|muscle cell differentiation|cellular protein metabolic process|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|oogenesis|regulation of gene silencing by miRNA|extracellular exosome|regulation of centromere complex assembly|negative regulation of chromosome condensation" "hsa05034,hsa05131,hsa05202,hsa05322" Alcoholism|Shigellosis|Transcriptional misregulation in cancer|Systemic lupus erythematosus H3-5 9.888962303 7.282897178 12.49502743 1.715667148 0.778769686 0.540720238 1 0.348900213 0.588579929 440093 H3.5 histone "GO:0000786,GO:0000791,GO:0005515,GO:0005634,GO:0030307,GO:0031492,GO:0046982" nucleosome|euchromatin|protein binding|nucleus|positive regulation of cell growth|nucleosomal DNA binding|protein heterodimerization activity "hsa05034,hsa05131,hsa05202,hsa05322" Alcoholism|Shigellosis|Transcriptional misregulation in cancer|Systemic lupus erythematosus H3C4 7.243268215 13.52538047 0.961155956 0.071063136 -3.814754828 0.020868228 0.821508434 0.769535925 0.053770546 8351 H3 clustered histone 4 "GO:0000183,GO:0000228,GO:0000786,GO:0003677,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0032200,GO:0032991,GO:0038111,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0046982,GO:0060964,GO:0060968,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|nucleosome|DNA binding|protein binding|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|telomere organization|protein-containing complex|interleukin-7-mediated signaling pathway|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome" "hsa05034,hsa05131,hsa05202,hsa05322" Alcoholism|Shigellosis|Transcriptional misregulation in cancer|Systemic lupus erythematosus H3C6 7.763475156 14.56579436 0.961155956 0.065987198 -3.921670032 0.014961903 0.712638468 0.287907287 0.018680286 8353 H3 clustered histone 6 "GO:0000183,GO:0000228,GO:0000786,GO:0003677,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0032200,GO:0032991,GO:0038111,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0046982,GO:0060964,GO:0060968,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|nucleosome|DNA binding|protein binding|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|telomere organization|protein-containing complex|interleukin-7-mediated signaling pathway|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome" "hsa05034,hsa05131,hsa05202,hsa05322" Alcoholism|Shigellosis|Transcriptional misregulation in cancer|Systemic lupus erythematosus H3C7 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.306296188 8968 H3 clustered histone 7 "GO:0000183,GO:0000228,GO:0000786,GO:0003677,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0032200,GO:0032991,GO:0038111,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0046982,GO:0060964,GO:0060968,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|nucleosome|DNA binding|protein binding|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|telomere organization|protein-containing complex|interleukin-7-mediated signaling pathway|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome" "hsa05034,hsa05131,hsa05202,hsa05322" Alcoholism|Shigellosis|Transcriptional misregulation in cancer|Systemic lupus erythematosus H3C8 5.04355356 6.242483296 3.844623824 0.615880514 -0.699277611 0.760739355 1 0.671673105 0.406748164 8355 H3 clustered histone 8 "GO:0000183,GO:0000228,GO:0000786,GO:0003677,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0032200,GO:0032991,GO:0038111,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0046982,GO:0060964,GO:0060968,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|nucleosome|DNA binding|protein binding|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|telomere organization|protein-containing complex|interleukin-7-mediated signaling pathway|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome" "hsa05034,hsa05131,hsa05202,hsa05322" Alcoholism|Shigellosis|Transcriptional misregulation in cancer|Systemic lupus erythematosus H4C12 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.430426176 0.130327577 8362 H4 clustered histone 12 "GO:0000183,GO:0000228,GO:0000781,GO:0000786,GO:0003677,GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006303,GO:0006334,GO:0006335,GO:0006336,GO:0006352,GO:0016020,GO:0016233,GO:0019904,GO:0032200,GO:0032991,GO:0034080,GO:0044267,GO:0045652,GO:0045653,GO:0045814,GO:0046982,GO:0060964,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|chromosome, telomeric region|nucleosome|DNA binding|RNA binding|protein binding|extracellular region|nucleus|nucleoplasm|double-strand break repair via nonhomologous end joining|nucleosome assembly|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|DNA-templated transcription, initiation|membrane|telomere capping|protein domain specific binding|telomere organization|protein-containing complex|CENP-A containing nucleosome assembly|cellular protein metabolic process|regulation of megakaryocyte differentiation|negative regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|extracellular exosome" "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H4C8 3.641448589 7.282897178 0 0 #NAME? 0.060320757 1 0.950305225 0 8365 H4 clustered histone 8 "GO:0000183,GO:0000228,GO:0000781,GO:0000786,GO:0003677,GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006303,GO:0006334,GO:0006335,GO:0006336,GO:0006352,GO:0016020,GO:0016233,GO:0019904,GO:0032200,GO:0032991,GO:0034080,GO:0044267,GO:0045652,GO:0045653,GO:0045814,GO:0046982,GO:0060964,GO:0070062" "rDNA heterochromatin assembly|nuclear chromosome|chromosome, telomeric region|nucleosome|DNA binding|RNA binding|protein binding|extracellular region|nucleus|nucleoplasm|double-strand break repair via nonhomologous end joining|nucleosome assembly|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|DNA-templated transcription, initiation|membrane|telomere capping|protein domain specific binding|telomere organization|protein-containing complex|CENP-A containing nucleosome assembly|cellular protein metabolic process|regulation of megakaryocyte differentiation|negative regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|regulation of gene silencing by miRNA|extracellular exosome" "hsa05034,hsa05203,hsa05322" Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus H6PD 1002.256221 1066.42423 938.088213 0.879657632 -0.184985967 0.452774848 1 3.902701854 3.375594173 9563 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase "GO:0004345,GO:0005739,GO:0005788,GO:0006006,GO:0009051,GO:0017057,GO:0030246,GO:0047936,GO:0050661,GO:0097305,GO:2000064" "glucose-6-phosphate dehydrogenase activity|mitochondrion|endoplasmic reticulum lumen|glucose metabolic process|pentose-phosphate shunt, oxidative branch|6-phosphogluconolactonase activity|carbohydrate binding|glucose 1-dehydrogenase [NAD(P)] activity|NADP binding|response to alcohol|regulation of cortisol biosynthetic process" hsa00030 Pentose phosphate pathway HAAO 13.85247302 10.40413883 17.30080721 1.662877389 0.733681797 0.488071191 1 0.391848812 0.640692945 23498 "3-hydroxyanthranilate 3,4-dioxygenase" "GO:0000334,GO:0005515,GO:0005737,GO:0005829,GO:0006569,GO:0008198,GO:0009055,GO:0009435,GO:0010043,GO:0019805,GO:0022900,GO:0034354,GO:0043420,GO:0046686,GO:0046874,GO:0070050" "3-hydroxyanthranilate 3,4-dioxygenase activity|protein binding|cytoplasm|cytosol|tryptophan catabolic process|ferrous iron binding|electron transfer activity|NAD biosynthetic process|response to zinc ion|quinolinate biosynthetic process|electron transport chain|'de novo' NAD biosynthetic process from tryptophan|anthranilate metabolic process|response to cadmium ion|quinolinate metabolic process|neuron cellular homeostasis" hsa00380 Tryptophan metabolism HABP4 1102.583777 949.8978749 1255.269679 1.321478563 0.402153022 0.099050182 1 16.43251337 21.35183945 22927 hyaluronan binding protein 4 "GO:0002576,GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0006397,GO:0008380,GO:0010494,GO:0015030,GO:0016528,GO:0016607,GO:0030017,GO:0030578,GO:0032183,GO:0033120,GO:0043392,GO:0045948,GO:0071260,GO:0097504" platelet degranulation|RNA binding|protein binding|extracellular region|nucleus|nucleoplasm|nucleolus|cytoplasm|Golgi apparatus|cytosol|mRNA processing|RNA splicing|cytoplasmic stress granule|Cajal body|sarcoplasm|nuclear speck|sarcomere|PML body organization|SUMO binding|positive regulation of RNA splicing|negative regulation of DNA binding|positive regulation of translational initiation|cellular response to mechanical stimulus|Gemini of coiled bodies HACD1 235.5065182 240.3356069 230.6774294 0.959813789 -0.059173556 0.874774547 1 5.743963109 5.420880146 9200 3-hydroxyacyl-CoA dehydratase 1 "GO:0005515,GO:0005789,GO:0007275,GO:0018812,GO:0030148,GO:0030176,GO:0030497,GO:0035338,GO:0042761,GO:0102158,GO:0102343,GO:0102344,GO:0102345" protein binding|endoplasmic reticulum membrane|multicellular organism development|3-hydroxyacyl-CoA dehydratase activity|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation|long-chain fatty-acyl-CoA biosynthetic process|very long-chain fatty acid biosynthetic process|very-long-chain 3-hydroxyacyl-CoA dehydratase activity|3-hydroxy-arachidoyl-CoA dehydratase activity|3-hydroxy-behenoyl-CoA dehydratase activity|3-hydroxy-lignoceroyl-CoA dehydratase activity "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids HACD2 1460.279175 1483.630197 1436.928154 0.968521777 -0.046143607 0.849491708 1 11.02305677 10.49742095 201562 3-hydroxyacyl-CoA dehydratase 2 "GO:0004725,GO:0005515,GO:0005783,GO:0005789,GO:0018812,GO:0019899,GO:0030148,GO:0030176,GO:0030497,GO:0035335,GO:0035338,GO:0042761,GO:0102158,GO:0102343,GO:0102344,GO:0102345" protein tyrosine phosphatase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|3-hydroxyacyl-CoA dehydratase activity|enzyme binding|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation|peptidyl-tyrosine dephosphorylation|long-chain fatty-acyl-CoA biosynthetic process|very long-chain fatty acid biosynthetic process|very-long-chain 3-hydroxyacyl-CoA dehydratase activity|3-hydroxy-arachidoyl-CoA dehydratase activity|3-hydroxy-behenoyl-CoA dehydratase activity|3-hydroxy-lignoceroyl-CoA dehydratase activity "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids HACD3 2993.806806 2568.781876 3418.831735 1.330915547 0.412419028 0.081668213 1 41.97525031 54.93067951 51495 3-hydroxyacyl-CoA dehydratase 3 "GO:0005096,GO:0005515,GO:0005783,GO:0005925,GO:0007249,GO:0007257,GO:0007264,GO:0016601,GO:0018812,GO:0019899,GO:0030148,GO:0030176,GO:0030497,GO:0031965,GO:0042761,GO:0043547,GO:0045070,GO:0046726,GO:0102158,GO:0102343,GO:0102344,GO:0102345" GTPase activator activity|protein binding|endoplasmic reticulum|focal adhesion|I-kappaB kinase/NF-kappaB signaling|activation of JUN kinase activity|small GTPase mediated signal transduction|Rac protein signal transduction|3-hydroxyacyl-CoA dehydratase activity|enzyme binding|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation|nuclear membrane|very long-chain fatty acid biosynthetic process|positive regulation of GTPase activity|positive regulation of viral genome replication|positive regulation by virus of viral protein levels in host cell|very-long-chain 3-hydroxyacyl-CoA dehydratase activity|3-hydroxy-arachidoyl-CoA dehydratase activity|3-hydroxy-behenoyl-CoA dehydratase activity|3-hydroxy-lignoceroyl-CoA dehydratase activity "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids HACD4 760.6757966 792.7953786 728.5562146 0.918971319 -0.121908259 0.633239149 1 4.831567004 4.365772919 401494 3-hydroxyacyl-CoA dehydratase 4 "GO:0005515,GO:0005783,GO:0018812,GO:0019899,GO:0030148,GO:0030176,GO:0030497,GO:0042761,GO:0102158,GO:0102343,GO:0102344,GO:0102345" protein binding|endoplasmic reticulum|3-hydroxyacyl-CoA dehydratase activity|enzyme binding|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation|very long-chain fatty acid biosynthetic process|very-long-chain 3-hydroxyacyl-CoA dehydratase activity|3-hydroxy-arachidoyl-CoA dehydratase activity|3-hydroxy-behenoyl-CoA dehydratase activity|3-hydroxy-lignoceroyl-CoA dehydratase activity "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids HACE1 425.0266198 408.8826559 441.1705838 1.078966245 0.109649731 0.705956103 1 4.600741271 4.88097797 57531 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 "GO:0000139,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0006511,GO:0007030,GO:0007049,GO:0016567,GO:0016601,GO:0016604,GO:0030334,GO:0031267,GO:0032580,GO:0043161,GO:0045732,GO:0061025,GO:0061630,GO:0070936" Golgi membrane|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum|ubiquitin-dependent protein catabolic process|Golgi organization|cell cycle|protein ubiquitination|Rac protein signal transduction|nuclear body|regulation of cell migration|small GTPase binding|Golgi cisterna membrane|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of protein catabolic process|membrane fusion|ubiquitin protein ligase activity|protein K48-linked ubiquitination HACL1 629.7321024 559.7426689 699.721536 1.250077178 0.322017168 0.217005 1 14.86930686 18.27673981 26061 2-hydroxyacyl-CoA lyase 1 "GO:0000287,GO:0001561,GO:0005515,GO:0005524,GO:0005654,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0006631,GO:0016830,GO:0030976,GO:0042802,GO:0043231,GO:0097089,GO:1903512" magnesium ion binding|fatty acid alpha-oxidation|protein binding|ATP binding|nucleoplasm|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid metabolic process|carbon-carbon lyase activity|thiamine pyrophosphate binding|identical protein binding|intracellular membrane-bounded organelle|methyl-branched fatty acid metabolic process|phytanic acid metabolic process hsa04146 Peroxisome HADH 594.9373736 542.0556329 647.8191143 1.195115547 0.257150109 0.329976523 1 13.38663252 15.7308582 3033 hydroxyacyl-CoA dehydrogenase "GO:0003857,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006635,GO:0016740,GO:0042802,GO:0050796,GO:0070403,GO:0120162" 3-hydroxyacyl-CoA dehydrogenase activity|nucleoplasm|cytoplasm|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|transferase activity|identical protein binding|regulation of insulin secretion|NAD+ binding|positive regulation of cold-induced thermogenesis "hsa00062,hsa00071,hsa00280,hsa00310,hsa00380,hsa00650" "Fatty acid elongation|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|Butanoate metabolism" HADHA 5062.100913 4937.804287 5186.397539 1.050344898 0.070863138 0.768507501 1 89.54180751 92.47598493 3030 hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha "GO:0003857,GO:0003985,GO:0004300,GO:0005515,GO:0005739,GO:0005743,GO:0006635,GO:0016507,GO:0016509,GO:0035965,GO:0042645" 3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|enoyl-CoA hydratase activity|protein binding|mitochondrion|mitochondrial inner membrane|fatty acid beta-oxidation|mitochondrial fatty acid beta-oxidation multienzyme complex|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|cardiolipin acyl-chain remodeling|mitochondrial nucleoid "hsa00062,hsa00071,hsa00280,hsa00310,hsa00380,hsa00410,hsa00640,hsa00650" "Fatty acid elongation|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|beta-Alanine metabolism|Propanoate metabolism|Butanoate metabolism" HADHB 1378.126108 1320.285217 1435.966998 1.087618781 0.121172969 0.614859332 1 31.0675465 33.22422306 3032 hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta "GO:0003723,GO:0003857,GO:0003988,GO:0004300,GO:0005515,GO:0005739,GO:0005740,GO:0005741,GO:0005743,GO:0005783,GO:0006635,GO:0035965,GO:0042645,GO:0050633" RNA binding|3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding|mitochondrion|mitochondrial envelope|mitochondrial outer membrane|mitochondrial inner membrane|endoplasmic reticulum|fatty acid beta-oxidation|cardiolipin acyl-chain remodeling|mitochondrial nucleoid|acetyl-CoA C-myristoyltransferase activity "hsa00062,hsa00071,hsa00280" "Fatty acid elongation|Fatty acid degradation|Valine, leucine and isoleucine degradation" HAGH 587.1537768 577.4297049 596.8778487 1.033680539 0.047790387 0.86258424 1 11.16939546 11.35238696 3029 hydroxyacylglutathione hydrolase "GO:0004416,GO:0005515,GO:0005759,GO:0005829,GO:0006090,GO:0006750,GO:0019243,GO:0046872" hydroxyacylglutathione hydrolase activity|protein binding|mitochondrial matrix|cytosol|pyruvate metabolic process|glutathione biosynthetic process|methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione|metal ion binding hsa00620 Pyruvate metabolism HAGHL 222.7491792 195.5978099 249.9005486 1.277624472 0.353463851 0.313354898 1 5.741856778 7.213179766 84264 hydroxyacylglutathione hydrolase like "GO:0005515,GO:0016787,GO:0046872" protein binding|hydrolase activity|metal ion binding HAL 4.082397604 6.242483296 1.922311912 0.307940257 -1.699277611 0.406294648 1 0.076270572 0.02309376 3034 histidine ammonia-lyase "GO:0004397,GO:0005829,GO:0006548,GO:0016841,GO:0019556,GO:0019557" histidine ammonia-lyase activity|cytosol|histidine catabolic process|ammonia-lyase activity|histidine catabolic process to glutamate and formamide|histidine catabolic process to glutamate and formate hsa00340 Histidine metabolism HAP1 25.01962298 26.01034707 24.0288989 0.923820772 -0.11431511 0.937424536 1 0.317068163 0.288012633 9001 huntingtin associated protein 1 "GO:0005102,GO:0005515,GO:0005730,GO:0005739,GO:0005764,GO:0005769,GO:0005776,GO:0005783,GO:0005813,GO:0005814,GO:0005829,GO:0005856,GO:0006605,GO:0006887,GO:0006914,GO:0007268,GO:0007420,GO:0008021,GO:0008089,GO:0008090,GO:0008104,GO:0015629,GO:0016234,GO:0017022,GO:0017157,GO:0021549,GO:0021979,GO:0022008,GO:0030030,GO:0030425,GO:0030426,GO:0031410,GO:0031587,GO:0032230,GO:0032901,GO:0043197,GO:0044325,GO:0045742,GO:0047496,GO:0048011,GO:0048311,GO:0048403,GO:0050769,GO:0098957,GO:1902430,GO:1902513,GO:1902857,GO:1904115" "signaling receptor binding|protein binding|nucleolus|mitochondrion|lysosome|early endosome|autophagosome|endoplasmic reticulum|centrosome|centriole|cytosol|cytoskeleton|protein targeting|exocytosis|autophagy|chemical synaptic transmission|brain development|synaptic vesicle|anterograde axonal transport|retrograde axonal transport|protein localization|actin cytoskeleton|inclusion body|myosin binding|regulation of exocytosis|cerebellum development|hypothalamus cell differentiation|neurogenesis|cell projection organization|dendrite|growth cone|cytoplasmic vesicle|positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|positive regulation of synaptic transmission, GABAergic|positive regulation of neurotrophin production|dendritic spine|ion channel binding|positive regulation of epidermal growth factor receptor signaling pathway|vesicle transport along microtubule|neurotrophin TRK receptor signaling pathway|mitochondrion distribution|brain-derived neurotrophic factor binding|positive regulation of neurogenesis|anterograde axonal transport of mitochondrion|negative regulation of amyloid-beta formation|regulation of organelle transport along microtubule|positive regulation of non-motile cilium assembly|axon cytoplasm" "hsa04727,hsa05014,hsa05016,hsa05022" GABAergic synapse|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases HAPLN3 94.08384325 72.82897178 115.3387147 1.583692752 0.663292469 0.166301607 1 1.860578444 2.897277493 145864 hyaluronan and proteoglycan link protein 3 "GO:0001501,GO:0005540,GO:0005615,GO:0007155,GO:0007417,GO:0031012" skeletal system development|hyaluronic acid binding|extracellular space|cell adhesion|central nervous system development|extracellular matrix HARBI1 70.16880082 88.43518002 51.90242162 0.586897902 -0.768818544 0.147261644 1 1.528870431 0.882275901 283254 harbinger transposase derived 1 "GO:0004518,GO:0005634,GO:0005829,GO:0005886,GO:0034451,GO:0046872,GO:0090305" nuclease activity|nucleus|cytosol|plasma membrane|centriolar satellite|metal ion binding|nucleic acid phosphodiester bond hydrolysis HARS1 1561.230733 1408.720397 1713.74107 1.216523217 0.282763854 0.235356193 1 38.59384932 46.16466382 3035 histidyl-tRNA synthetase 1 "GO:0004821,GO:0005524,GO:0005737,GO:0005739,GO:0005829,GO:0006412,GO:0006418,GO:0006427,GO:0032543,GO:0042802,GO:0042803" histidine-tRNA ligase activity|ATP binding|cytoplasm|mitochondrion|cytosol|translation|tRNA aminoacylation for protein translation|histidyl-tRNA aminoacylation|mitochondrial translation|identical protein binding|protein homodimerization activity hsa00970 Aminoacyl-tRNA biosynthesis HARS2 908.5447444 864.5839365 952.5055524 1.1016924 0.139721471 0.575497852 1 18.69580861 20.25236686 23438 "histidyl-tRNA synthetase 2, mitochondrial" "GO:0003723,GO:0004821,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0005829,GO:0006412,GO:0006418,GO:0006427,GO:0042802" RNA binding|histidine-tRNA ligase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|cytosol|translation|tRNA aminoacylation for protein translation|histidyl-tRNA aminoacylation|identical protein binding hsa00970 Aminoacyl-tRNA biosynthesis HAS2 543.5123427 251.7801596 835.2445258 3.317356408 1.73003402 4.22E-10 1.12E-06 3.169114237 10.33715924 3037 hyaluronan synthase 2 "GO:0001570,GO:0001822,GO:0005515,GO:0005887,GO:0008284,GO:0010838,GO:0014911,GO:0030213,GO:0030335,GO:0031410,GO:0035810,GO:0036120,GO:0036302,GO:0042802,GO:0044849,GO:0044853,GO:0045226,GO:0050501,GO:0051549,GO:0060349,GO:0070295,GO:0071347,GO:0071356,GO:0071498,GO:0085029,GO:0090500,GO:1900026,GO:1900127,GO:1900625,GO:1901201" vasculogenesis|kidney development|protein binding|integral component of plasma membrane|positive regulation of cell population proliferation|positive regulation of keratinocyte proliferation|positive regulation of smooth muscle cell migration|hyaluronan biosynthetic process|positive regulation of cell migration|cytoplasmic vesicle|positive regulation of urine volume|cellular response to platelet-derived growth factor stimulus|atrioventricular canal development|identical protein binding|estrous cycle|plasma membrane raft|extracellular polysaccharide biosynthetic process|hyaluronan synthase activity|positive regulation of keratinocyte migration|bone morphogenesis|renal water absorption|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to fluid shear stress|extracellular matrix assembly|endocardial cushion to mesenchymal transition|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of hyaluronan biosynthetic process|positive regulation of monocyte aggregation|regulation of extracellular matrix assembly HAS3 506.699724 471.3074888 542.0919592 1.150187451 0.201869002 0.461260551 1 5.073177582 5.737462608 3038 hyaluronan synthase 3 "GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0005887,GO:0005975,GO:0016021,GO:0030213,GO:0036117,GO:0042802,GO:0045226,GO:0045893,GO:0050501,GO:0085029,GO:1900106" "protein binding|nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|carbohydrate metabolic process|integral component of membrane|hyaluronan biosynthetic process|hyaluranon cable|identical protein binding|extracellular polysaccharide biosynthetic process|positive regulation of transcription, DNA-templated|hyaluronan synthase activity|extracellular matrix assembly|positive regulation of hyaluranon cable assembly" HASPIN 346.2168619 396.3976893 296.0360344 0.746815742 -0.421175757 0.162042804 1 7.563466618 5.553995669 83903 histone H3 associated protein kinase "GO:0000278,GO:0004672,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005813,GO:0005819,GO:0006468,GO:0007064,GO:0035556,GO:0071459,GO:0072354,GO:0106310,GO:0106311,GO:2000751" "mitotic cell cycle|protein kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|chromosome|cytoplasm|centrosome|spindle|protein phosphorylation|mitotic sister chromatid cohesion|intracellular signal transduction|protein localization to chromosome, centromeric region|histone kinase activity (H3-T3 specific)|protein serine kinase activity|protein threonine kinase activity|histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore" HAT1 2102.343988 1849.855883 2354.832092 1.272981378 0.348211315 0.140991252 1 37.95594333 47.508686 8520 histone acetyltransferase 1 "GO:0000781,GO:0000785,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006323,GO:0006335,GO:0006336,GO:0006348,GO:0006475,GO:0007584,GO:0010485,GO:0016363,GO:0032991,GO:0042393,GO:0043967" "chromosome, telomeric region|chromatin|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|DNA packaging|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|chromatin silencing at telomere|internal protein amino acid acetylation|response to nutrient|H4 histone acetyltransferase activity|nuclear matrix|protein-containing complex|histone binding|histone H4 acetylation" hsa05034 Alcoholism HAUS1 722.1660061 652.3395044 791.9925077 1.214080249 0.279863784 0.273059182 1 32.4758959 38.76856383 115106 HAUS augmin like complex subunit 1 "GO:0000086,GO:0000922,GO:0003674,GO:0005515,GO:0005813,GO:0005829,GO:0007098,GO:0010389,GO:0051225,GO:0051301,GO:0070652,GO:0097711,GO:1990498" G2/M transition of mitotic cell cycle|spindle pole|molecular_function|protein binding|centrosome|cytosol|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking|mitotic spindle microtubule HAUS2 873.0467551 803.1995174 942.8939928 1.173922509 0.231337179 0.353934179 1 9.959405675 11.4959279 55142 HAUS augmin like complex subunit 2 "GO:0000086,GO:0003674,GO:0005515,GO:0005813,GO:0005829,GO:0007098,GO:0010389,GO:0051225,GO:0051301,GO:0070652,GO:0097711,GO:1990498" G2/M transition of mitotic cell cycle|molecular_function|protein binding|centrosome|cytosol|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking|mitotic spindle microtubule HAUS3 462.6104673 461.9437639 463.2771708 1.002886513 0.00415836 0.997029136 1 4.193415489 4.135146161 79441 HAUS augmin like complex subunit 3 "GO:0000086,GO:0003674,GO:0005515,GO:0005654,GO:0005739,GO:0005813,GO:0005829,GO:0007098,GO:0010389,GO:0015630,GO:0045171,GO:0051225,GO:0051301,GO:0070652,GO:0072686,GO:0097711,GO:1990498" G2/M transition of mitotic cell cycle|molecular_function|protein binding|nucleoplasm|mitochondrion|centrosome|cytosol|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|intercellular bridge|spindle assembly|cell division|HAUS complex|mitotic spindle|ciliary basal body-plasma membrane docking|mitotic spindle microtubule HAUS4 1180.069459 1167.344376 1192.794541 1.021801763 0.03111533 0.901402693 1 39.28059513 39.46534332 54930 HAUS augmin like complex subunit 4 "GO:0000086,GO:0003674,GO:0005515,GO:0005813,GO:0005829,GO:0007098,GO:0010389,GO:0051011,GO:0051225,GO:0051301,GO:0070652,GO:0097711,GO:1990498" G2/M transition of mitotic cell cycle|molecular_function|protein binding|centrosome|cytosol|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|microtubule minus-end binding|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking|mitotic spindle microtubule HAUS5 384.6976987 409.9230698 359.4723275 0.876926316 -0.189472469 0.520582221 1 5.19393182 4.478478837 23354 HAUS augmin like complex subunit 5 "GO:0000086,GO:0003674,GO:0005515,GO:0005813,GO:0005829,GO:0007098,GO:0010389,GO:0051225,GO:0051301,GO:0070652,GO:0097711,GO:1990498" G2/M transition of mitotic cell cycle|molecular_function|protein binding|centrosome|cytosol|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking|mitotic spindle microtubule HAUS6 1948.842697 1642.813521 2254.871873 1.37256715 0.456876732 0.053760787 1 12.82157623 17.30398771 54801 HAUS augmin like complex subunit 6 "GO:0000086,GO:0003674,GO:0005515,GO:0005813,GO:0005829,GO:0007098,GO:0010389,GO:0016607,GO:0034451,GO:0051225,GO:0051301,GO:0070652,GO:0097711,GO:1990498" G2/M transition of mitotic cell cycle|molecular_function|protein binding|centrosome|cytosol|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|nuclear speck|centriolar satellite|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking|mitotic spindle microtubule HAUS7 447.6880123 423.4484502 471.9275744 1.114486484 0.15637912 0.581722198 1 14.34835906 15.72346364 55559 HAUS augmin like complex subunit 7 "GO:0000086,GO:0005515,GO:0005813,GO:0005829,GO:0007098,GO:0010389,GO:0031996,GO:0051011,GO:0051225,GO:0051301,GO:0070652,GO:0097711,GO:1990498" G2/M transition of mitotic cell cycle|protein binding|centrosome|cytosol|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|thioesterase binding|microtubule minus-end binding|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking|mitotic spindle microtubule HAUS8 249.1507855 270.5076095 227.7939616 0.842098165 -0.247939674 0.463707806 1 9.721544745 8.049505084 93323 HAUS augmin like complex subunit 8 "GO:0000086,GO:0000922,GO:0003674,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005880,GO:0007098,GO:0008017,GO:0010389,GO:0051225,GO:0051301,GO:0070652,GO:0097711,GO:1990498" G2/M transition of mitotic cell cycle|spindle pole|molecular_function|protein binding|cytoplasm|centrosome|cytosol|nuclear microtubule|centrosome cycle|microtubule binding|regulation of G2/M transition of mitotic cell cycle|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking|mitotic spindle microtubule HAVCR2 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.067639838 84868 hepatitis A virus cellular receptor 2 "GO:0001772,GO:0002250,GO:0002281,GO:0002519,GO:0002652,GO:0002826,GO:0002859,GO:0005515,GO:0005769,GO:0006954,GO:0009986,GO:0010629,GO:0016021,GO:0030054,GO:0030886,GO:0032088,GO:0032687,GO:0032689,GO:0032703,GO:0032712,GO:0032715,GO:0032720,GO:0032722,GO:0032729,GO:0032732,GO:0032753,GO:0032760,GO:0032815,GO:0034138,GO:0034154,GO:0034162,GO:0042102,GO:0042130,GO:0043032,GO:0045087,GO:0045089,GO:0046872,GO:0050830,GO:0060135,GO:0070374,GO:0071222,GO:0071656,GO:1900425,GO:1900426,GO:1901224,GO:2000521,GO:2001189" immunological synapse|adaptive immune response|macrophage activation involved in immune response|natural killer cell tolerance induction|regulation of tolerance induction dependent upon immune response|negative regulation of T-helper 1 type immune response|negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|protein binding|early endosome|inflammatory response|cell surface|negative regulation of gene expression|integral component of membrane|cell junction|negative regulation of myeloid dendritic cell activation|negative regulation of NF-kappaB transcription factor activity|negative regulation of interferon-alpha production|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|negative regulation of interleukin-3 production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-4 production|positive regulation of tumor necrosis factor production|negative regulation of natural killer cell activation|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway|positive regulation of T cell proliferation|negative regulation of T cell proliferation|positive regulation of macrophage activation|innate immune response|positive regulation of innate immune response|metal ion binding|defense response to Gram-positive bacterium|maternal process involved in female pregnancy|positive regulation of ERK1 and ERK2 cascade|cellular response to lipopolysaccharide|negative regulation of granulocyte colony-stimulating factor production|negative regulation of defense response to bacterium|positive regulation of defense response to bacterium|positive regulation of NIK/NF-kappaB signaling|negative regulation of immunological synapse formation|negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell HAX1 1462.83052 1512.761785 1412.899255 0.933986612 -0.098526224 0.681866449 1 72.7983013 66.85487409 10456 HCLS1 associated protein X-1 "GO:0000932,GO:0005515,GO:0005635,GO:0005667,GO:0005739,GO:0005741,GO:0005758,GO:0005783,GO:0005938,GO:0007005,GO:0014068,GO:0015629,GO:0016324,GO:0016529,GO:0019966,GO:0030027,GO:0030136,GO:0030833,GO:0030854,GO:0031965,GO:0033138,GO:0042981,GO:0043066,GO:0045944,GO:0047485,GO:0050731,GO:0051897,GO:0071345,GO:1903146,GO:1903214,GO:2000251" P-body|protein binding|nuclear envelope|transcription regulator complex|mitochondrion|mitochondrial outer membrane|mitochondrial intermembrane space|endoplasmic reticulum|cell cortex|mitochondrion organization|positive regulation of phosphatidylinositol 3-kinase signaling|actin cytoskeleton|apical plasma membrane|sarcoplasmic reticulum|interleukin-1 binding|lamellipodium|clathrin-coated vesicle|regulation of actin filament polymerization|positive regulation of granulocyte differentiation|nuclear membrane|positive regulation of peptidyl-serine phosphorylation|regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of transcription by RNA polymerase II|protein N-terminus binding|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling|cellular response to cytokine stimulus|regulation of autophagy of mitochondrion|regulation of protein targeting to mitochondrion|positive regulation of actin cytoskeleton reorganization HBE1 67.44887923 80.11186896 54.78588949 0.683867325 -0.548211636 0.311594305 1 6.862637572 4.614600361 3046 hemoglobin subunit epsilon 1 "GO:0004601,GO:0005344,GO:0005515,GO:0005829,GO:0005833,GO:0007596,GO:0014070,GO:0015671,GO:0019825,GO:0020037,GO:0031720,GO:0031721,GO:0031838,GO:0042744,GO:0043177,GO:0044877,GO:0046872,GO:0072562,GO:0098869" peroxidase activity|oxygen carrier activity|protein binding|cytosol|hemoglobin complex|blood coagulation|response to organic cyclic compound|oxygen transport|oxygen binding|heme binding|haptoglobin binding|hemoglobin alpha binding|haptoglobin-hemoglobin complex|hydrogen peroxide catabolic process|organic acid binding|protein-containing complex binding|metal ion binding|blood microparticle|cellular oxidant detoxification HBEGF 1205.124295 1105.959957 1304.288632 1.179327175 0.237964014 0.325992526 1 25.03097975 29.02574219 1839 heparin binding EGF like growth factor "GO:0000165,GO:0005154,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0005887,GO:0007165,GO:0007173,GO:0007517,GO:0008016,GO:0008083,GO:0008201,GO:0008284,GO:0009986,GO:0030307,GO:0030335,GO:0030665,GO:0030666,GO:0030669,GO:0035313,GO:0038128,GO:0042059,GO:0045741,GO:0048661,GO:0051545,GO:0051549,GO:0051897,GO:0060326,GO:0061024,GO:0090303,GO:2000145" "MAPK cascade|epidermal growth factor receptor binding|protein binding|extracellular region|extracellular space|plasma membrane|integral component of plasma membrane|signal transduction|epidermal growth factor receptor signaling pathway|muscle organ development|regulation of heart contraction|growth factor activity|heparin binding|positive regulation of cell population proliferation|cell surface|positive regulation of cell growth|positive regulation of cell migration|clathrin-coated vesicle membrane|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|wound healing, spreading of epidermal cells|ERBB2 signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of epidermal growth factor-activated receptor activity|positive regulation of smooth muscle cell proliferation|negative regulation of elastin biosynthetic process|positive regulation of keratinocyte migration|positive regulation of protein kinase B signaling|cell chemotaxis|membrane organization|positive regulation of wound healing|regulation of cell motility" "hsa01522,hsa04012,hsa04912,hsa04915,hsa04928,hsa05120,hsa05171,hsa05205,hsa05219" "Endocrine resistance|ErbB signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Parathyroid hormone synthesis, secretion and action|Epithelial cell signaling in Helicobacter pylori infection|Coronavirus disease - COVID-19|Proteoglycans in cancer|Bladder cancer" HBG2 2.080827765 4.161655531 0 0 #NAME? 0.234194363 1 0.37901008 0 3048 hemoglobin subunit gamma 2 "GO:0004601,GO:0005344,GO:0005515,GO:0005829,GO:0005833,GO:0007596,GO:0015671,GO:0019825,GO:0020037,GO:0031720,GO:0031721,GO:0031838,GO:0042744,GO:0043177,GO:0046872,GO:0072562,GO:0098869" peroxidase activity|oxygen carrier activity|protein binding|cytosol|hemoglobin complex|blood coagulation|oxygen transport|oxygen binding|heme binding|haptoglobin binding|hemoglobin alpha binding|haptoglobin-hemoglobin complex|hydrogen peroxide catabolic process|organic acid binding|metal ion binding|blood microparticle|cellular oxidant detoxification HBP1 1292.469371 1304.679009 1280.259733 0.981283308 -0.027258376 0.913132078 1 19.13391613 18.46160505 26959 HMG-box transcription factor 1 "GO:0000785,GO:0000978,GO:0000981,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007050,GO:0016055,GO:0016607" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cell cycle arrest|Wnt signaling pathway|nuclear speck" HMG HBS1L 1258.275336 1088.272921 1428.277751 1.312426068 0.392236154 0.104023754 1 6.180602921 7.975848008 10767 HBS1 like translational GTPase "GO:0003746,GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0006412,GO:0006414,GO:0007165,GO:0016020,GO:0043928,GO:0070062" translation elongation factor activity|GTPase activity|protein binding|GTP binding|cytosol|translation|translational elongation|signal transduction|membrane|exonucleolytic catabolism of deadenylated mRNA|extracellular exosome "hsa03015,hsa05134" mRNA surveillance pathway|Legionellosis HCAR1 408.7561657 435.9334168 381.5789145 0.875314669 -0.192126346 0.507323789 1 4.878373924 4.198657712 27198 hydroxycarboxylic acid receptor 1 "GO:0004930,GO:0005886,GO:0007186,GO:0016021" G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane hsa04024 cAMP signaling pathway HCAR2 15.09103172 17.687036 12.49502743 0.706451178 -0.501338233 0.64014501 1 0.457106346 0.317519632 338442 hydroxycarboxylic acid receptor 2 "GO:0001781,GO:0005886,GO:0007186,GO:0016021,GO:0030054,GO:0033031,GO:0050995,GO:0070165,GO:0070553" neutrophil apoptotic process|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|cell junction|positive regulation of neutrophil apoptotic process|negative regulation of lipid catabolic process|positive regulation of adiponectin secretion|nicotinic acid receptor activity hsa04024 cAMP signaling pathway HCAR3 73.24538309 106.122216 40.36855015 0.380396788 -1.394423029 0.008213332 0.561586569 2.754643787 1.030323171 8843 hydroxycarboxylic acid receptor 3 "GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0030054" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|cell junction hsa04024 cAMP signaling pathway HCCS 971.9017796 862.5031087 1081.30045 1.253677163 0.326165885 0.185839758 1 9.246726737 11.39842686 3052 holocytochrome c synthase "GO:0004408,GO:0005515,GO:0005739,GO:0005743,GO:0009887,GO:0016020,GO:0018063,GO:0018215,GO:0020037,GO:0046872,GO:0055114" holocytochrome-c synthase activity|protein binding|mitochondrion|mitochondrial inner membrane|animal organ morphogenesis|membrane|cytochrome c-heme linkage|protein phosphopantetheinylation|heme binding|metal ion binding|oxidation-reduction process hsa00860 Porphyrin and chlorophyll metabolism HCFC1 1990.164915 2058.979074 1921.350756 0.93315701 -0.09980825 0.674423896 1 12.36596094 11.34628719 3054 host cell factor C1 "GO:0000122,GO:0000123,GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005671,GO:0005737,GO:0006338,GO:0006355,GO:0007005,GO:0007049,GO:0010628,GO:0016020,GO:0016579,GO:0019046,GO:0030674,GO:0032991,GO:0033613,GO:0035097,GO:0042802,GO:0043025,GO:0043254,GO:0043981,GO:0043982,GO:0043984,GO:0045296,GO:0045787,GO:0045893,GO:0045944,GO:0048188,GO:0050821,GO:0070461,GO:0071339" "negative regulation of transcription by RNA polymerase II|histone acetyltransferase complex|chromatin binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|chromatin remodeling|regulation of transcription, DNA-templated|mitochondrion organization|cell cycle|positive regulation of gene expression|membrane|protein deubiquitination|release from viral latency|protein-macromolecule adaptor activity|protein-containing complex|activating transcription factor binding|histone methyltransferase complex|identical protein binding|neuronal cell body|regulation of protein-containing complex assembly|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|cadherin binding|positive regulation of cell cycle|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|Set1C/COMPASS complex|protein stabilization|SAGA-type complex|MLL1 complex" hsa05168 Herpes simplex virus 1 infection other HCFC1R1 1154.634039 1079.94961 1229.318468 1.138310951 0.186894711 0.442558465 1 75.14331921 84.10512627 54985 host cell factor C1 regulator 1 "GO:0005654,GO:0005737" nucleoplasm|cytoplasm HCFC2 348.1592955 346.4578229 349.860768 1.009822105 0.014101163 0.973315278 1 3.014316473 2.99298747 29915 host cell factor C2 "GO:0000122,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006338,GO:0006355,GO:0006357,GO:0016032,GO:0016604,GO:0035097,GO:0045893,GO:0071339" "negative regulation of transcription by RNA polymerase II|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|chromatin remodeling|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|viral process|nuclear body|histone methyltransferase complex|positive regulation of transcription, DNA-templated|MLL1 complex" hsa05168 Herpes simplex virus 1 infection HCK 2.601034707 5.202069413 0 0 #NAME? 0.147074026 1 0.124439661 0 3055 "HCK proto-oncogene, Src family tyrosine kinase" "GO:0001784,GO:0002522,GO:0002758,GO:0004713,GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005634,GO:0005764,GO:0005794,GO:0005829,GO:0005884,GO:0005886,GO:0005901,GO:0005925,GO:0006468,GO:0006954,GO:0007155,GO:0007169,GO:0007229,GO:0007498,GO:0008284,GO:0008360,GO:0018108,GO:0019221,GO:0030133,GO:0030154,GO:0030838,GO:0031234,GO:0031663,GO:0038083,GO:0038096,GO:0042127,GO:0042995,GO:0043066,GO:0043231,GO:0043299,GO:0045087,GO:0045728,GO:0046777,GO:0050690,GO:0050727,GO:0050764,GO:0051090,GO:0060333,GO:0071801,GO:2000251" phosphotyrosine residue binding|leukocyte migration involved in immune response|innate immune response-activating signal transduction|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|protein binding|ATP binding|nucleus|lysosome|Golgi apparatus|cytosol|actin filament|plasma membrane|caveola|focal adhesion|protein phosphorylation|inflammatory response|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|integrin-mediated signaling pathway|mesoderm development|positive regulation of cell population proliferation|regulation of cell shape|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|transport vesicle|cell differentiation|positive regulation of actin filament polymerization|extrinsic component of cytoplasmic side of plasma membrane|lipopolysaccharide-mediated signaling pathway|peptidyl-tyrosine autophosphorylation|Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of cell population proliferation|cell projection|negative regulation of apoptotic process|intracellular membrane-bounded organelle|leukocyte degranulation|innate immune response|respiratory burst after phagocytosis|protein autophosphorylation|regulation of defense response to virus by virus|regulation of inflammatory response|regulation of phagocytosis|regulation of DNA-binding transcription factor activity|interferon-gamma-mediated signaling pathway|regulation of podosome assembly|positive regulation of actin cytoskeleton reorganization "hsa04062,hsa04666,hsa05167" Chemokine signaling pathway|Fc gamma R-mediated phagocytosis|Kaposi sarcoma-associated herpesvirus infection HCLS1 41.39387278 39.53572754 43.25201802 1.093998282 0.129610473 0.876958195 1 1.059211403 1.139384918 3059 hematopoietic cell-specific Lyn substrate 1 "GO:0000122,GO:0001085,GO:0005515,GO:0005634,GO:0005667,GO:0005737,GO:0005739,GO:0005829,GO:0005884,GO:0005886,GO:0006355,GO:0008284,GO:0009725,GO:0014068,GO:0017124,GO:0019901,GO:0030041,GO:0030218,GO:0030427,GO:0030833,GO:0030854,GO:0030864,GO:0033138,GO:0035556,GO:0042307,GO:0042531,GO:0045651,GO:0045944,GO:0050731,GO:0051015,GO:0051091,GO:0051897,GO:0071345,GO:2000107,GO:2000251" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription factor binding|protein binding|nucleus|transcription regulator complex|cytoplasm|mitochondrion|cytosol|actin filament|plasma membrane|regulation of transcription, DNA-templated|positive regulation of cell population proliferation|response to hormone|positive regulation of phosphatidylinositol 3-kinase signaling|SH3 domain binding|protein kinase binding|actin filament polymerization|erythrocyte differentiation|site of polarized growth|regulation of actin filament polymerization|positive regulation of granulocyte differentiation|cortical actin cytoskeleton|positive regulation of peptidyl-serine phosphorylation|intracellular signal transduction|positive regulation of protein import into nucleus|positive regulation of tyrosine phosphorylation of STAT protein|positive regulation of macrophage differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of peptidyl-tyrosine phosphorylation|actin filament binding|positive regulation of DNA-binding transcription factor activity|positive regulation of protein kinase B signaling|cellular response to cytokine stimulus|negative regulation of leukocyte apoptotic process|positive regulation of actin cytoskeleton reorganization" "hsa04530,hsa05100,hsa05130,hsa05131,hsa05205" Tight junction|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Proteoglycans in cancer HCN2 256.850094 245.5376763 268.1625117 1.092144048 0.127163153 0.710242967 1 3.831548101 4.114578798 610 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 "GO:0005222,GO:0005248,GO:0005249,GO:0005515,GO:0005886,GO:0005887,GO:0007267,GO:0008076,GO:0030552,GO:0034765,GO:0035725,GO:0042391,GO:0042802,GO:0071320,GO:0071321,GO:0071805,GO:0086012,GO:0098719,GO:0098855,GO:1990573" intracellular cAMP-activated cation channel activity|voltage-gated sodium channel activity|voltage-gated potassium channel activity|protein binding|plasma membrane|integral component of plasma membrane|cell-cell signaling|voltage-gated potassium channel complex|cAMP binding|regulation of ion transmembrane transport|sodium ion transmembrane transport|regulation of membrane potential|identical protein binding|cellular response to cAMP|cellular response to cGMP|potassium ion transmembrane transport|membrane depolarization during cardiac muscle cell action potential|sodium ion import across plasma membrane|HCN channel complex|potassium ion import across plasma membrane "hsa04024,hsa04929" cAMP signaling pathway|GnRH secretion HCN3 211.165618 219.5273292 202.8039067 0.923820772 -0.11431511 0.758758265 1 2.389023264 2.170097669 57657 hyperpolarization activated cyclic nucleotide gated potassium channel 3 "GO:0005248,GO:0005249,GO:0005515,GO:0005886,GO:0005887,GO:0030425,GO:0030552,GO:0034765,GO:0035725,GO:0042391,GO:0043025,GO:0044316,GO:0071320,GO:0071805,GO:0072718,GO:1903351" voltage-gated sodium channel activity|voltage-gated potassium channel activity|protein binding|plasma membrane|integral component of plasma membrane|dendrite|cAMP binding|regulation of ion transmembrane transport|sodium ion transmembrane transport|regulation of membrane potential|neuronal cell body|cone cell pedicle|cellular response to cAMP|potassium ion transmembrane transport|response to cisplatin|cellular response to dopamine hsa04929 GnRH secretion HCST 3.923881751 2.080827765 5.766935736 2.771462315 1.470647391 0.503574097 1 0.130647004 0.356024275 10870 hematopoietic cell signal transducer "GO:0005102,GO:0005515,GO:0005886,GO:0006468,GO:0009986,GO:0014068,GO:0016021,GO:0043548,GO:0050776" signaling receptor binding|protein binding|plasma membrane|protein phosphorylation|cell surface|positive regulation of phosphatidylinositol 3-kinase signaling|integral component of membrane|phosphatidylinositol 3-kinase binding|regulation of immune response hsa04650 Natural killer cell mediated cytotoxicity HDAC1 2641.414815 2489.710421 2793.119208 1.121865091 0.165899196 0.483330456 1 53.12725681 58.60426249 3065 histone deacetylase 1 "GO:0000118,GO:0000122,GO:0000785,GO:0000792,GO:0000978,GO:0000979,GO:0001046,GO:0001085,GO:0001103,GO:0002039,GO:0003714,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006325,GO:0006338,GO:0006346,GO:0006357,GO:0006476,GO:0007492,GO:0007596,GO:0008134,GO:0008284,GO:0009913,GO:0010629,GO:0010832,GO:0016575,GO:0016580,GO:0016581,GO:0019213,GO:0019899,GO:0021766,GO:0030182,GO:0031492,GO:0032041,GO:0032922,GO:0032991,GO:0033558,GO:0033613,GO:0035851,GO:0042475,GO:0042733,GO:0042826,GO:0043025,GO:0043044,GO:0043066,GO:0043124,GO:0043922,GO:0045652,GO:0045892,GO:0045893,GO:0045944,GO:0047485,GO:0048714,GO:0051059,GO:0052548,GO:0060766,GO:0060789,GO:0061029,GO:0061198,GO:0070491,GO:0070888,GO:0070932,GO:0070933,GO:0090090,GO:1900221,GO:1901796,GO:1904837,GO:1990841,GO:2000273,GO:2001243" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|chromatin|heterochromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|core promoter sequence-specific DNA binding|RNA polymerase II transcription factor binding|RNA polymerase II repressing transcription factor binding|p53 binding|transcription corepressor activity|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|chromatin organization|chromatin remodeling|DNA methylation-dependent heterochromatin assembly|regulation of transcription by RNA polymerase II|protein deacetylation|endoderm development|blood coagulation|transcription factor binding|positive regulation of cell population proliferation|epidermal cell differentiation|negative regulation of gene expression|negative regulation of myotube differentiation|histone deacetylation|Sin3 complex|NuRD complex|deacetylase activity|enzyme binding|hippocampus development|neuron differentiation|nucleosomal DNA binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|circadian regulation of gene expression|protein-containing complex|protein deacetylase activity|activating transcription factor binding|Krueppel-associated box domain binding|odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|histone deacetylase binding|neuronal cell body|ATP-dependent chromatin remodeling|negative regulation of apoptotic process|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation by host of viral transcription|regulation of megakaryocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein N-terminus binding|positive regulation of oligodendrocyte differentiation|NF-kappaB binding|regulation of endopeptidase activity|negative regulation of androgen receptor signaling pathway|hair follicle placode formation|eyelid development in camera-type eye|fungiform papilla formation|repressing transcription factor binding|E-box binding|histone H3 deacetylation|histone H4 deacetylation|negative regulation of canonical Wnt signaling pathway|regulation of amyloid-beta clearance|regulation of signal transduction by p53 class mediator|beta-catenin-TCF complex assembly|promoter-specific chromatin binding|positive regulation of signaling receptor activity|negative regulation of intrinsic apoptotic signaling pathway" "hsa04110,hsa04213,hsa04330,hsa04919,hsa05016,hsa05031,hsa05034,hsa05165,hsa05169,hsa05200,hsa05202,hsa05203,hsa05206,hsa05220" Cell cycle|Longevity regulating pathway - multiple species|Notch signaling pathway|Thyroid hormone signaling pathway|Huntington disease|Amphetamine addiction|Alcoholism|Human papillomavirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|MicroRNAs in cancer|Chronic myeloid leukemia chromosome_remodelling_factor HDAC10 393.1499574 404.7210003 381.5789145 0.942819657 -0.084946258 0.777254105 1 8.414186187 7.800311113 83933 histone deacetylase 10 "GO:0000118,GO:0000122,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006281,GO:0006325,GO:0006355,GO:0006476,GO:0008270,GO:0014003,GO:0016236,GO:0016575,GO:0019213,GO:0019899,GO:0032425,GO:0033558,GO:0034983,GO:0035825,GO:0042826,GO:0045892,GO:0047609,GO:0047611,GO:0106047,GO:0106048" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|DNA repair|chromatin organization|regulation of transcription, DNA-templated|protein deacetylation|zinc ion binding|oligodendrocyte development|macroautophagy|histone deacetylation|deacetylase activity|enzyme binding|positive regulation of mismatch repair|protein deacetylase activity|peptidyl-lysine deacetylation|homologous recombination|histone deacetylase binding|negative regulation of transcription, DNA-templated|acetylputrescine deacetylase activity|acetylspermidine deacetylase activity|polyamine deacetylation|spermidine deacetylation" "hsa05034,hsa05203" Alcoholism|Viral carcinogenesis HDAC11 354.5703554 338.1345119 371.006199 1.097214824 0.133846019 0.660804254 1 3.790299818 4.089181712 79885 histone deacetylase 11 "GO:0000118,GO:0004407,GO:0005515,GO:0005634,GO:0005886,GO:0006325,GO:0008134,GO:0014003,GO:0016575,GO:0032041,GO:0070932" histone deacetylase complex|histone deacetylase activity|protein binding|nucleus|plasma membrane|chromatin organization|transcription factor binding|oligodendrocyte development|histone deacetylation|NAD-dependent histone deacetylase activity (H3-K14 specific)|histone H3 deacetylation "hsa05034,hsa05203" Alcoholism|Viral carcinogenesis HDAC2 2241.085756 2110.999768 2371.171743 1.123245857 0.167673741 0.4786477 1 11.20996794 12.3808475 3066 histone deacetylase 2 "GO:0000118,GO:0000122,GO:0000785,GO:0001103,GO:0001975,GO:0003300,GO:0003682,GO:0003723,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006338,GO:0007596,GO:0008134,GO:0008284,GO:0009913,GO:0010718,GO:0010977,GO:0016358,GO:0016575,GO:0016580,GO:0016581,GO:0019213,GO:0019899,GO:0031000,GO:0031072,GO:0031492,GO:0032041,GO:0032496,GO:0032732,GO:0032760,GO:0032922,GO:0032967,GO:0032991,GO:0033558,GO:0034605,GO:0035094,GO:0035098,GO:0042220,GO:0042475,GO:0042493,GO:0042531,GO:0042733,GO:0042826,GO:0043044,GO:0043066,GO:0043392,GO:0043433,GO:0043565,GO:0045347,GO:0045862,GO:0045892,GO:0045893,GO:0045944,GO:0048149,GO:0048714,GO:0051059,GO:0055093,GO:0060789,GO:0061000,GO:0061029,GO:0061198,GO:0070301,GO:0070829,GO:0070932,GO:0070933,GO:0071300,GO:0071560,GO:1901796,GO:1902437,GO:1903351,GO:1990841,GO:2000273,GO:2000757" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II repressing transcription factor binding|response to amphetamine|cardiac muscle hypertrophy|chromatin binding|RNA binding|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|chromatin remodeling|blood coagulation|transcription factor binding|positive regulation of cell population proliferation|epidermal cell differentiation|positive regulation of epithelial to mesenchymal transition|negative regulation of neuron projection development|dendrite development|histone deacetylation|Sin3 complex|NuRD complex|deacetylase activity|enzyme binding|response to caffeine|heat shock protein binding|nucleosomal DNA binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|response to lipopolysaccharide|positive regulation of interleukin-1 production|positive regulation of tumor necrosis factor production|circadian regulation of gene expression|positive regulation of collagen biosynthetic process|protein-containing complex|protein deacetylase activity|cellular response to heat|response to nicotine|ESC/E(Z) complex|response to cocaine|odontogenesis of dentin-containing tooth|response to drug|positive regulation of tyrosine phosphorylation of STAT protein|embryonic digit morphogenesis|histone deacetylase binding|ATP-dependent chromatin remodeling|negative regulation of apoptotic process|negative regulation of DNA binding|negative regulation of DNA-binding transcription factor activity|sequence-specific DNA binding|negative regulation of MHC class II biosynthetic process|positive regulation of proteolysis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|behavioral response to ethanol|positive regulation of oligodendrocyte differentiation|NF-kappaB binding|response to hyperoxia|hair follicle placode formation|negative regulation of dendritic spine development|eyelid development in camera-type eye|fungiform papilla formation|cellular response to hydrogen peroxide|heterochromatin maintenance|histone H3 deacetylation|histone H4 deacetylation|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|regulation of signal transduction by p53 class mediator|positive regulation of male mating behavior|cellular response to dopamine|promoter-specific chromatin binding|positive regulation of signaling receptor activity|negative regulation of peptidyl-lysine acetylation" "hsa04110,hsa04213,hsa04330,hsa04919,hsa05016,hsa05031,hsa05034,hsa05165,hsa05169,hsa05200,hsa05202,hsa05203,hsa05206,hsa05220" Cell cycle|Longevity regulating pathway - multiple species|Notch signaling pathway|Thyroid hormone signaling pathway|Huntington disease|Amphetamine addiction|Alcoholism|Human papillomavirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|MicroRNAs in cancer|Chronic myeloid leukemia chromosome_remodelling_factor HDAC3 1745.365098 1625.126485 1865.603711 1.147974467 0.199090555 0.401922983 1 38.05617097 42.95646123 8841 histone deacetylase 3 "GO:0000118,GO:0000122,GO:0001226,GO:0001934,GO:0003682,GO:0003714,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0006325,GO:0006476,GO:0007623,GO:0008134,GO:0010832,GO:0017053,GO:0019216,GO:0019899,GO:0030332,GO:0031398,GO:0031647,GO:0032008,GO:0032041,GO:0032922,GO:0033558,GO:0042307,GO:0042752,GO:0042826,GO:0043066,GO:0045892,GO:0045944,GO:0046329,GO:0051059,GO:0051225,GO:0070932,GO:0070933,GO:0071498,GO:0072686,GO:0120162" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription corepressor binding|positive regulation of protein phosphorylation|chromatin binding|transcription corepressor activity|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|plasma membrane|chromatin organization|protein deacetylation|circadian rhythm|transcription factor binding|negative regulation of myotube differentiation|transcription repressor complex|regulation of lipid metabolic process|enzyme binding|cyclin binding|positive regulation of protein ubiquitination|regulation of protein stability|positive regulation of TOR signaling|NAD-dependent histone deacetylase activity (H3-K14 specific)|circadian regulation of gene expression|protein deacetylase activity|positive regulation of protein import into nucleus|regulation of circadian rhythm|histone deacetylase binding|negative regulation of apoptotic process|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of JNK cascade|NF-kappaB binding|spindle assembly|histone H3 deacetylation|histone H4 deacetylation|cellular response to fluid shear stress|mitotic spindle|positive regulation of cold-induced thermogenesis" "hsa04919,hsa05034,hsa05203" Thyroid hormone signaling pathway|Alcoholism|Viral carcinogenesis other HDAC4 57.48568942 58.26317743 56.7082014 0.97331117 -0.039026983 0.979599862 1 0.125556176 0.120160289 9759 histone deacetylase 4 "GO:0000118,GO:0000122,GO:0000976,GO:0000978,GO:0001085,GO:0001501,GO:0002076,GO:0003714,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006338,GO:0006476,GO:0006954,GO:0007399,GO:0008134,GO:0008270,GO:0008284,GO:0008285,GO:0010592,GO:0010832,GO:0010882,GO:0014894,GO:0014898,GO:0014911,GO:0016575,GO:0016607,GO:0016925,GO:0017053,GO:0019789,GO:0019901,GO:0030018,GO:0030183,GO:0030955,GO:0031594,GO:0031672,GO:0032041,GO:0033235,GO:0033558,GO:0033613,GO:0034983,GO:0040029,GO:0042113,GO:0042493,GO:0042641,GO:0042802,GO:0042826,GO:0043393,GO:0043433,GO:0043525,GO:0043565,GO:0045668,GO:0045820,GO:0045892,GO:0045893,GO:0045944,GO:0048661,GO:0048742,GO:0051091,GO:0070491,GO:0070555,GO:0070932,GO:0070933,GO:0071260,GO:0071356,GO:0071374,GO:1902437,GO:1902894,GO:1903428,GO:1990841" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding|skeletal system development|osteoblast development|transcription corepressor activity|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|chromatin remodeling|protein deacetylation|inflammatory response|nervous system development|transcription factor binding|zinc ion binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|positive regulation of lamellipodium assembly|negative regulation of myotube differentiation|regulation of cardiac muscle contraction by calcium ion signaling|response to denervation involved in regulation of muscle adaptation|cardiac muscle hypertrophy in response to stress|positive regulation of smooth muscle cell migration|histone deacetylation|nuclear speck|protein sumoylation|transcription repressor complex|SUMO transferase activity|protein kinase binding|Z disc|B cell differentiation|potassium ion binding|neuromuscular junction|A band|NAD-dependent histone deacetylase activity (H3-K14 specific)|positive regulation of protein sumoylation|protein deacetylase activity|activating transcription factor binding|peptidyl-lysine deacetylation|regulation of gene expression, epigenetic|B cell activation|response to drug|actomyosin|identical protein binding|histone deacetylase binding|regulation of protein binding|negative regulation of DNA-binding transcription factor activity|positive regulation of neuron apoptotic process|sequence-specific DNA binding|negative regulation of osteoblast differentiation|negative regulation of glycolytic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of smooth muscle cell proliferation|regulation of skeletal muscle fiber development|positive regulation of DNA-binding transcription factor activity|repressing transcription factor binding|response to interleukin-1|histone H3 deacetylation|histone H4 deacetylation|cellular response to mechanical stimulus|cellular response to tumor necrosis factor|cellular response to parathyroid hormone stimulus|positive regulation of male mating behavior|negative regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of reactive oxygen species biosynthetic process|promoter-specific chromatin binding" "hsa04371,hsa05034,hsa05203,hsa05206" Apelin signaling pathway|Alcoholism|Viral carcinogenesis|MicroRNAs in cancer HDAC5 1060.762817 1075.787955 1045.73768 0.972066731 -0.040872739 0.870954466 1 10.21035496 9.759062481 10014 histone deacetylase 5 "GO:0000118,GO:0000122,GO:0000976,GO:0000978,GO:0001085,GO:0003682,GO:0004407,GO:0005080,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006325,GO:0006338,GO:0006342,GO:0006476,GO:0006954,GO:0008134,GO:0010830,GO:0010832,GO:0014823,GO:0016575,GO:0016607,GO:0030182,GO:0030183,GO:0032041,GO:0032869,GO:0033558,GO:0040029,GO:0042113,GO:0042220,GO:0042493,GO:0042802,GO:0042826,GO:0043393,GO:0045892,GO:0045944,GO:0046872,GO:0051091,GO:0070491,GO:0070932,GO:0071222,GO:0090051,GO:2000615" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding|chromatin binding|histone deacetylase activity|protein kinase C binding|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|chromatin organization|chromatin remodeling|chromatin silencing|protein deacetylation|inflammatory response|transcription factor binding|regulation of myotube differentiation|negative regulation of myotube differentiation|response to activity|histone deacetylation|nuclear speck|neuron differentiation|B cell differentiation|NAD-dependent histone deacetylase activity (H3-K14 specific)|cellular response to insulin stimulus|protein deacetylase activity|regulation of gene expression, epigenetic|B cell activation|response to cocaine|response to drug|identical protein binding|histone deacetylase binding|regulation of protein binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of DNA-binding transcription factor activity|repressing transcription factor binding|histone H3 deacetylation|cellular response to lipopolysaccharide|negative regulation of cell migration involved in sprouting angiogenesis|regulation of histone H3-K9 acetylation" "hsa04371,hsa05034,hsa05203,hsa05206" Apelin signaling pathway|Alcoholism|Viral carcinogenesis|MicroRNAs in cancer HDAC6 952.3314463 929.0895972 975.5732953 1.050031448 0.070432537 0.778962362 1 8.980946243 9.272473093 10013 histone deacetylase 6 "GO:0000118,GO:0000209,GO:0000978,GO:0001226,GO:0003779,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005771,GO:0005829,GO:0005874,GO:0005875,GO:0005901,GO:0006476,GO:0006515,GO:0006886,GO:0006914,GO:0007026,GO:0008013,GO:0008017,GO:0008270,GO:0010506,GO:0010634,GO:0010727,GO:0016234,GO:0016235,GO:0016241,GO:0016575,GO:0019899,GO:0030286,GO:0030424,GO:0030425,GO:0031252,GO:0031333,GO:0031593,GO:0031625,GO:0031647,GO:0031648,GO:0032041,GO:0032418,GO:0032984,GO:0033138,GO:0033558,GO:0034983,GO:0035967,GO:0040029,GO:0042826,GO:0042903,GO:0043014,GO:0043130,GO:0043162,GO:0043204,GO:0043242,GO:0045598,GO:0045861,GO:0045892,GO:0047611,GO:0048156,GO:0048471,GO:0048487,GO:0048668,GO:0051354,GO:0051646,GO:0051787,GO:0051788,GO:0051879,GO:0060271,GO:0060632,GO:0060765,GO:0060997,GO:0061734,GO:0070201,GO:0070301,GO:0070840,GO:0070842,GO:0070845,GO:0070846,GO:0070848,GO:0070932,GO:0071218,GO:0090042,GO:0106047,GO:0106048,GO:1901300,GO:1903146,GO:2000273" "histone deacetylase complex|protein polyubiquitination|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II transcription corepressor binding|actin binding|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|multivesicular body|cytosol|microtubule|microtubule associated complex|caveola|protein deacetylation|protein quality control for misfolded or incompletely synthesized proteins|intracellular protein transport|autophagy|negative regulation of microtubule depolymerization|beta-catenin binding|microtubule binding|zinc ion binding|regulation of autophagy|positive regulation of epithelial cell migration|negative regulation of hydrogen peroxide metabolic process|inclusion body|aggresome|regulation of macroautophagy|histone deacetylation|enzyme binding|dynein complex|axon|dendrite|cell leading edge|negative regulation of protein-containing complex assembly|polyubiquitin modification-dependent protein binding|ubiquitin protein ligase binding|regulation of protein stability|protein destabilization|NAD-dependent histone deacetylase activity (H3-K14 specific)|lysosome localization|protein-containing complex disassembly|positive regulation of peptidyl-serine phosphorylation|protein deacetylase activity|peptidyl-lysine deacetylation|cellular response to topologically incorrect protein|regulation of gene expression, epigenetic|histone deacetylase binding|tubulin deacetylase activity|alpha-tubulin binding|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|perikaryon|negative regulation of protein-containing complex disassembly|regulation of fat cell differentiation|negative regulation of proteolysis|negative regulation of transcription, DNA-templated|acetylspermidine deacetylase activity|tau protein binding|perinuclear region of cytoplasm|beta-tubulin binding|collateral sprouting|negative regulation of oxidoreductase activity|mitochondrion localization|misfolded protein binding|response to misfolded protein|Hsp90 protein binding|cilium assembly|regulation of microtubule-based movement|regulation of androgen receptor signaling pathway|dendritic spine morphogenesis|parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization|regulation of establishment of protein localization|cellular response to hydrogen peroxide|dynein complex binding|aggresome assembly|polyubiquitinated misfolded protein transport|Hsp90 deacetylation|response to growth factor|histone H3 deacetylation|cellular response to misfolded protein|tubulin deacetylation|polyamine deacetylation|spermidine deacetylation|positive regulation of hydrogen peroxide-mediated programmed cell death|regulation of autophagy of mitochondrion|positive regulation of signaling receptor activity" "hsa05014,hsa05034,hsa05203" Amyotrophic lateral sclerosis|Alcoholism|Viral carcinogenesis other HDAC7 1737.035527 1822.805122 1651.265932 0.905892743 -0.142587848 0.548878053 1 16.52450471 14.71893578 51564 histone deacetylase 7 "GO:0000118,GO:0005080,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006476,GO:0019901,GO:0032041,GO:0032703,GO:0033558,GO:0033613,GO:0045668,GO:0046872,GO:0070491,GO:0070932,GO:0071889,GO:0090050,GO:1901223" histone deacetylase complex|protein kinase C binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein deacetylation|protein kinase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|negative regulation of interleukin-2 production|protein deacetylase activity|activating transcription factor binding|negative regulation of osteoblast differentiation|metal ion binding|repressing transcription factor binding|histone H3 deacetylation|14-3-3 protein binding|positive regulation of cell migration involved in sprouting angiogenesis|negative regulation of NIK/NF-kappaB signaling "hsa05034,hsa05203" Alcoholism|Viral carcinogenesis HDAC8 510.7770912 490.0349387 531.5192437 1.084655811 0.117237311 0.671220499 1 7.186662279 7.664615311 55869 histone deacetylase 8 "GO:0000118,GO:0000122,GO:0000228,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0006325,GO:0006333,GO:0007062,GO:0008134,GO:0030544,GO:0031397,GO:0031647,GO:0032041,GO:0032204,GO:0045944,GO:0046872,GO:0051879,GO:0070932,GO:0070933,GO:0071922" histone deacetylase complex|negative regulation of transcription by RNA polymerase II|nuclear chromosome|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|plasma membrane|chromatin organization|chromatin assembly or disassembly|sister chromatid cohesion|transcription factor binding|Hsp70 protein binding|negative regulation of protein ubiquitination|regulation of protein stability|NAD-dependent histone deacetylase activity (H3-K14 specific)|regulation of telomere maintenance|positive regulation of transcription by RNA polymerase II|metal ion binding|Hsp90 protein binding|histone H3 deacetylation|histone H4 deacetylation|regulation of cohesin loading "hsa05034,hsa05203" Alcoholism|Viral carcinogenesis chromosome_remodelling_factor HDAC9 974.7745723 988.3931885 961.155956 0.972442918 -0.040314528 0.874045901 1 3.896345685 3.725570421 9734 histone deacetylase 9 "GO:0000118,GO:0000122,GO:0001818,GO:0001975,GO:0003714,GO:0004407,GO:0005080,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006954,GO:0007507,GO:0008134,GO:0016575,GO:0030182,GO:0030183,GO:0032041,GO:0032869,GO:0033558,GO:0034739,GO:0034983,GO:0035097,GO:0042113,GO:0042632,GO:0042826,GO:0045892,GO:0046872,GO:0048742,GO:0051005,GO:0051153,GO:0070491,GO:0070932,GO:0070933,GO:0090050,GO:1990678" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|negative regulation of cytokine production|response to amphetamine|transcription corepressor activity|histone deacetylase activity|protein kinase C binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|inflammatory response|heart development|transcription factor binding|histone deacetylation|neuron differentiation|B cell differentiation|NAD-dependent histone deacetylase activity (H3-K14 specific)|cellular response to insulin stimulus|protein deacetylase activity|histone deacetylase activity (H4-K16 specific)|peptidyl-lysine deacetylation|histone methyltransferase complex|B cell activation|cholesterol homeostasis|histone deacetylase binding|negative regulation of transcription, DNA-templated|metal ion binding|regulation of skeletal muscle fiber development|negative regulation of lipoprotein lipase activity|regulation of striated muscle cell differentiation|repressing transcription factor binding|histone H3 deacetylation|histone H4 deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|histone H4-K16 deacetylation" "hsa05034,hsa05203" Alcoholism|Viral carcinogenesis HDDC2 522.6078727 548.2981162 496.9176292 0.906290966 -0.141953791 0.6036683 1 17.9299404 15.97782556 51020 HD domain containing 2 "GO:0002953,GO:0005515,GO:0005737,GO:0016311,GO:0046872" 5'-deoxynucleotidase activity|protein binding|cytoplasm|dephosphorylation|metal ion binding HDDC3 197.9126098 212.2444321 183.5807876 0.86494984 -0.209311624 0.573141343 1 5.588108165 4.752552304 374659 HD domain containing 3 "GO:0005515,GO:0008893,GO:0046872" "protein binding|guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity|metal ion binding" hsa00230 Purine metabolism HDGF 8140.836772 8234.875881 8046.797664 0.977160771 -0.033332149 0.893100194 1 131.0316609 125.8964395 3068 heparin binding growth factor "GO:0000122,GO:0000166,GO:0001222,GO:0003690,GO:0003712,GO:0003714,GO:0003723,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007165,GO:0008083,GO:0008201,GO:0017053,GO:0036498,GO:0062023,GO:0098761" negative regulation of transcription by RNA polymerase II|nucleotide binding|transcription corepressor binding|double-stranded DNA binding|transcription coregulator activity|transcription corepressor activity|RNA binding|extracellular region|extracellular space|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|signal transduction|growth factor activity|heparin binding|transcription repressor complex|IRE1-mediated unfolded protein response|collagen-containing extracellular matrix|cellular response to interleukin-7 HDGFL2 1587.607802 1445.134883 1730.080721 1.197175946 0.259635197 0.275616342 1 26.90066015 31.66591917 84717 HDGF like 2 "GO:0003690,GO:0003712,GO:0005515,GO:0005634,GO:0006357,GO:0030307" double-stranded DNA binding|transcription coregulator activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of cell growth HDGFL3 1347.681733 1240.173348 1455.190117 1.173376383 0.23066586 0.337088883 1 4.258510632 4.913220522 50810 HDGF like 3 "GO:0003690,GO:0003712,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007026,GO:0007165,GO:0008017,GO:0008083,GO:0015631,GO:0031175,GO:0046785" double-stranded DNA binding|transcription coregulator activity|extracellular region|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|negative regulation of microtubule depolymerization|signal transduction|microtubule binding|growth factor activity|tubulin binding|neuron projection development|microtubule polymerization HDHD2 492.5799091 428.6505196 556.5092985 1.298282104 0.376603901 0.169904692 1 4.389157791 5.60301059 84064 haloacid dehalogenase like hydrolase domain containing 2 "GO:0005515,GO:0008150,GO:0016311,GO:0016791,GO:0019899,GO:0046872,GO:0070062" protein binding|biological_process|dephosphorylation|phosphatase activity|enzyme binding|metal ion binding|extracellular exosome HDHD3 315.6881986 326.6899591 304.686438 0.932647085 -0.100596829 0.753413158 1 6.918588369 6.34462573 81932 haloacid dehalogenase like hydrolase domain containing 3 "GO:0005515,GO:0005730,GO:0016787,GO:0043231" protein binding|nucleolus|hydrolase activity|intracellular membrane-bounded organelle HDHD5 500.917697 508.7623886 493.0730054 0.969161669 -0.045190749 0.875745074 1 8.225299489 7.838250294 27440 haloacid dehalogenase like hydrolase domain containing 5 "GO:0005739,GO:0046474" mitochondrion|glycerophospholipid biosynthetic process HDLBP 15090.79125 16494.7217 13686.86081 0.829772158 -0.269212845 0.305710298 1 118.9745886 97.06982544 3069 high density lipoprotein binding protein "GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0005886,GO:0006869,GO:0008203,GO:0008289,GO:0034364,GO:0034384,GO:0045296" RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|cytosol|polysome|plasma membrane|lipid transport|cholesterol metabolic process|lipid binding|high-density lipoprotein particle|high-density lipoprotein particle clearance|cadherin binding HDX 142.8744697 142.5367019 143.2122374 1.004739379 0.006821328 1 1 1.16885707 1.154744788 139324 highly divergent homeobox "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II" HEATR1 1871.288547 2092.272318 1650.304776 0.788761942 -0.342338152 0.148403608 1 13.20022794 10.23760943 55127 HEAT repeat containing 1 "GO:0000462,GO:0001650,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0006364,GO:0016020,GO:0030515,GO:0030686,GO:0032040,GO:0034455,GO:0045943,GO:2000234" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|fibrillar center|RNA binding|protein binding|nucleoplasm|nucleolus|mitochondrion|rRNA processing|membrane|snoRNA binding|90S preribosome|small-subunit processome|t-UTP complex|positive regulation of transcription by RNA polymerase I|positive regulation of rRNA processing" hsa03008 Ribosome biogenesis in eukaryotes HEATR3 298.045822 279.8713344 316.2203095 1.129877449 0.176166301 0.581986534 1 3.142482377 3.491205156 55027 HEAT repeat containing 3 "GO:0006606,GO:0042273,GO:0051082" protein import into nucleus|ribosomal large subunit biogenesis|unfolded protein binding HEATR5A 968.9975757 1013.363122 924.6320297 0.912438996 -0.132199988 0.593897897 1 6.923739255 6.211775062 25938 HEAT repeat containing 5A "GO:0005829,GO:0006897,GO:0008104,GO:0030139,GO:0042147" "cytosol|endocytosis|protein localization|endocytic vesicle|retrograde transport, endosome to Golgi" HEATR5B 961.8090277 963.4232553 960.1948 0.996648975 -0.004842625 0.989127815 1 6.99063609 6.850623466 54497 HEAT repeat containing 5B "GO:0005515,GO:0005829,GO:0006897,GO:0008104,GO:0016020,GO:0030139,GO:0042147" "protein binding|cytosol|endocytosis|protein localization|membrane|endocytic vesicle|retrograde transport, endosome to Golgi" HEATR6 1311.474224 1349.416806 1273.531642 0.943764474 -0.08350123 0.730719298 1 11.79042155 10.94117934 63897 HEAT repeat containing 6 GO:0003723 RNA binding HEBP1 1630.923987 1484.670611 1777.177363 1.197017945 0.25944478 0.275466308 1 68.36422931 80.46384133 50865 heme binding protein 1 "GO:0005576,GO:0005737,GO:0007186,GO:0007623,GO:0020037,GO:0070062" extracellular region|cytoplasm|G protein-coupled receptor signaling pathway|circadian rhythm|heme binding|extracellular exosome HEBP2 1008.390493 949.8978749 1066.883111 1.123155593 0.167557801 0.496635213 1 5.039195203 5.565091185 23593 heme binding protein 2 "GO:0005515,GO:0005576,GO:0005737,GO:0005739,GO:0010917,GO:0010940,GO:0020037,GO:0035578,GO:0035794,GO:0043312,GO:0070062,GO:1901031" protein binding|extracellular region|cytoplasm|mitochondrion|negative regulation of mitochondrial membrane potential|positive regulation of necrotic cell death|heme binding|azurophil granule lumen|positive regulation of mitochondrial membrane permeability|neutrophil degranulation|extracellular exosome|regulation of response to reactive oxygen species HECA 837.9199033 814.6440701 861.1957366 1.057143565 0.080171315 0.752429925 1 7.700328865 8.004135323 51696 "hdc homolog, cell cycle regulator" "GO:0003674,GO:0005634,GO:0005737,GO:0016020,GO:0030323,GO:0045930" molecular_function|nucleus|cytoplasm|membrane|respiratory tube development|negative regulation of mitotic cell cycle HECTD1 3610.702427 3876.582127 3344.822727 0.862827774 -0.212855478 0.370248334 1 22.42910486 19.0286175 25831 HECT domain E3 ubiquitin protein ligase 1 "GO:0003170,GO:0003281,GO:0005515,GO:0032436,GO:0035904,GO:0046872,GO:0048856,GO:0061630,GO:0070534" heart valve development|ventricular septum development|protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|aorta development|metal ion binding|anatomical structure development|ubiquitin protein ligase activity|protein K63-linked ubiquitination HECTD2 514.9337163 510.8432164 519.0242162 1.016014698 0.022921273 0.94040524 1 4.995009815 4.99008008 143279 HECT domain E3 ubiquitin protein ligase 2 "GO:0000209,GO:0004842,GO:0005829" protein polyubiquitination|ubiquitin-protein transferase activity|cytosol HECTD3 1275.242791 1319.244803 1231.24078 0.93329212 -0.09959938 0.681449668 1 19.5680018 17.95706098 79654 HECT domain E3 ubiquitin protein ligase 3 "GO:0004842,GO:0005515,GO:0016567,GO:0019905,GO:0043161,GO:0048471" ubiquitin-protein transferase activity|protein binding|protein ubiquitination|syntaxin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|perinuclear region of cytoplasm HECTD4 1712.877066 1945.573961 1480.180172 0.760793577 -0.394423029 0.096661176 1 6.579122194 4.921596086 283450 HECT domain E3 ubiquitin protein ligase 4 "GO:0004842,GO:0005515,GO:0006006,GO:0016021,GO:0016567,GO:0042593" ubiquitin-protein transferase activity|protein binding|glucose metabolic process|integral component of membrane|protein ubiquitination|glucose homeostasis HECW1 27.66028665 32.25283036 23.06774294 0.715216081 -0.48354892 0.539168717 1 0.140845616 0.099049385 23072 "HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1" "GO:0000209,GO:0005515,GO:0005737,GO:0005829,GO:0016567,GO:0043161,GO:0045732,GO:0048814,GO:0061630,GO:0090090,GO:2000650" protein polyubiquitination|protein binding|cytoplasm|cytosol|protein ubiquitination|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of protein catabolic process|regulation of dendrite morphogenesis|ubiquitin protein ligase activity|negative regulation of canonical Wnt signaling pathway|negative regulation of sodium ion transmembrane transporter activity HECW2 201.7622641 199.7594655 203.7650627 1.020052102 0.028642844 0.951920513 1 0.825458423 0.827920692 57520 "HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2" "GO:0000209,GO:0005515,GO:0005737,GO:0016567,GO:0030071,GO:0043161,GO:0045732,GO:0048814,GO:0061630,GO:0072686,GO:2000650" protein polyubiquitination|protein binding|cytoplasm|protein ubiquitination|regulation of mitotic metaphase/anaphase transition|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of protein catabolic process|regulation of dendrite morphogenesis|ubiquitin protein ligase activity|mitotic spindle|negative regulation of sodium ion transmembrane transporter activity HEG1 1319.455351 1420.16495 1218.745752 0.85817197 -0.220661316 0.359126375 1 8.019425798 6.766884706 57493 heart development protein with EGF like domains 1 "GO:0001570,GO:0001701,GO:0001886,GO:0001945,GO:0003017,GO:0003209,GO:0003222,GO:0003281,GO:0005509,GO:0005515,GO:0005576,GO:0005911,GO:0007043,GO:0007507,GO:0009791,GO:0009897,GO:0016021,GO:0030324,GO:0035024,GO:0035264,GO:0048845,GO:0050878,GO:0055017,GO:0060039,GO:0090271,GO:1902414,GO:1905709,GO:2000299" vasculogenesis|in utero embryonic development|endothelial cell morphogenesis|lymph vessel development|lymph circulation|cardiac atrium morphogenesis|ventricular trabecula myocardium morphogenesis|ventricular septum development|calcium ion binding|protein binding|extracellular region|cell-cell junction|cell-cell junction assembly|heart development|post-embryonic development|external side of plasma membrane|integral component of membrane|lung development|negative regulation of Rho protein signal transduction|multicellular organism growth|venous blood vessel morphogenesis|regulation of body fluid levels|cardiac muscle tissue growth|pericardium development|positive regulation of fibroblast growth factor production|protein localization to cell junction|negative regulation of membrane permeability|negative regulation of Rho-dependent protein serine/threonine kinase activity HELB 86.3449058 96.75849109 75.93132052 0.784750978 -0.349693173 0.486204493 1 1.469499953 1.133894427 92797 DNA helicase B "GO:0000462,GO:0003723,GO:0005524,GO:0005622,GO:0005634,GO:0005662,GO:0005730,GO:0005737,GO:0006260,GO:0006269,GO:0006281,GO:0006974,GO:0017116,GO:0032508,GO:0035861,GO:0043139,GO:0044877,GO:1903775,GO:2000042" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|ATP binding|intracellular anatomical structure|nucleus|DNA replication factor A complex|nucleolus|cytoplasm|DNA replication|DNA replication, synthesis of RNA primer|DNA repair|cellular response to DNA damage stimulus|single-stranded DNA helicase activity|DNA duplex unwinding|site of double-strand break|5'-3' DNA helicase activity|protein-containing complex binding|regulation of DNA double-strand break processing|negative regulation of double-strand break repair via homologous recombination" HELLS 1710.818203 1588.711999 1832.924408 1.153717231 0.206289672 0.38535866 1 11.03418004 12.51729892 3070 "helicase, lymphoid specific" "GO:0000775,GO:0003682,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005721,GO:0006306,GO:0006346,GO:0007049,GO:0007275,GO:0010216,GO:0031508,GO:0046651,GO:0051301" "chromosome, centromeric region|chromatin binding|helicase activity|protein binding|ATP binding|nucleus|pericentric heterochromatin|DNA methylation|DNA methylation-dependent heterochromatin assembly|cell cycle|multicellular organism development|maintenance of DNA methylation|pericentric heterochromatin assembly|lymphocyte proliferation|cell division" HELQ 199.8003232 198.7190516 200.8815948 1.010882415 0.015615194 0.981324405 1 2.155104766 2.142102301 113510 "helicase, POLQ like" "GO:0000724,GO:0003677,GO:0005515,GO:0005524,GO:0005634,GO:0006364,GO:0032508,GO:1990518" double-strand break repair via homologous recombination|DNA binding|protein binding|ATP binding|nucleus|rRNA processing|DNA duplex unwinding|single-stranded 3'-5' DNA helicase activity HELZ 1260.894649 1346.295564 1175.493734 0.873131997 -0.195728323 0.417785113 1 5.071597365 4.35407444 9931 helicase with zinc finger "GO:0003723,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0016020,GO:0035194,GO:0043186,GO:0046872" RNA binding|helicase activity|protein binding|ATP binding|nucleus|cytosol|membrane|post-transcriptional gene silencing by RNA|P granule|metal ion binding HELZ2 1337.405313 1399.356672 1275.453954 0.911457371 -0.133752912 0.579048154 1 7.439096891 6.666958554 85441 helicase with zinc finger 2 "GO:0000184,GO:0003677,GO:0003723,GO:0003724,GO:0004540,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0016020,GO:0019216,GO:0030374,GO:0045944,GO:0046872,GO:0090501" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|DNA binding|RNA binding|RNA helicase activity|ribonuclease activity|protein binding|ATP binding|nucleoplasm|cytoplasm|membrane|regulation of lipid metabolic process|nuclear receptor coactivator activity|positive regulation of transcription by RNA polymerase II|metal ion binding|RNA phosphodiester bond hydrolysis" HEMK1 522.3109627 490.0349387 554.5869866 1.13172948 0.178529149 0.512393412 1 1.458494453 1.623000259 51409 HemK methyltransferase family member 1 "GO:0003677,GO:0005515,GO:0005739,GO:0006306,GO:0006479,GO:0008170,GO:0008276,GO:0102559" DNA binding|protein binding|mitochondrion|DNA methylation|protein methylation|N-methyltransferase activity|protein methyltransferase activity|protein-(glutamine-N5) methyltransferase activity HENMT1 113.1629234 132.1325631 94.19328369 0.712869572 -0.488289953 0.277638644 1 3.701665114 2.594647607 113802 HEN methyltransferase 1 "GO:0001510,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0008171,GO:0008173,GO:0030422,GO:0034587,GO:0043186,GO:0046872,GO:0090486" RNA methylation|RNA binding|protein binding|nucleus|cytoplasm|O-methyltransferase activity|RNA methyltransferase activity|production of siRNA involved in RNA interference|piRNA metabolic process|P granule|metal ion binding|small RNA 2'-O-methyltransferase HEPHL1 6.965865472 6.242483296 7.689247648 1.231761029 0.300722389 0.937576592 1 0.057350639 0.069460179 341208 hephaestin like 1 "GO:0004322,GO:0005507,GO:0005886,GO:0006825,GO:0006826,GO:0006879,GO:0016021,GO:0016491,GO:0055072,GO:0055114" ferroxidase activity|copper ion binding|plasma membrane|copper ion transport|iron ion transport|cellular iron ion homeostasis|integral component of membrane|oxidoreductase activity|iron ion homeostasis|oxidation-reduction process HERC1 1190.141475 1217.284243 1162.998707 0.955404388 -0.065816592 0.788720046 1 4.203987754 3.949297519 8925 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 "GO:0004842,GO:0005085,GO:0005737,GO:0005794,GO:0005829,GO:0010507,GO:0016020,GO:0016567,GO:0021702,GO:0031175,GO:0050790,GO:0050885" ubiquitin-protein transferase activity|guanyl-nucleotide exchange factor activity|cytoplasm|Golgi apparatus|cytosol|negative regulation of autophagy|membrane|protein ubiquitination|cerebellar Purkinje cell differentiation|neuron projection development|regulation of catalytic activity|neuromuscular process controlling balance hsa04120 Ubiquitin mediated proteolysis HERC2 1570.390054 1636.571037 1504.209071 0.919122383 -0.121671124 0.610748778 1 5.381441058 4.86343492 8924 HECT and RLD domain containing E3 ubiquitin protein ligase 2 "GO:0005085,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005814,GO:0005829,GO:0005886,GO:0006303,GO:0006886,GO:0006974,GO:0008270,GO:0016020,GO:0016567,GO:0031625,GO:0032183,GO:0050790,GO:0061630" guanyl-nucleotide exchange factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|centriole|cytosol|plasma membrane|double-strand break repair via nonhomologous end joining|intracellular protein transport|cellular response to DNA damage stimulus|zinc ion binding|membrane|protein ubiquitination|ubiquitin protein ligase binding|SUMO binding|regulation of catalytic activity|ubiquitin protein ligase activity hsa04120 Ubiquitin mediated proteolysis HERC3 672.6815656 614.8846046 730.4785266 1.187992871 0.248526178 0.335996085 1 2.857974328 3.338438164 8916 HECT and RLD domain containing E3 ubiquitin protein ligase 3 "GO:0004842,GO:0005829,GO:0016567,GO:0031410" ubiquitin-protein transferase activity|cytosol|protein ubiquitination|cytoplasmic vesicle hsa04120 Ubiquitin mediated proteolysis HERC4 3626.899268 3734.045425 3519.753111 0.942611219 -0.085265242 0.720328034 1 23.61407056 21.8864155 26091 HECT and RLD domain containing E3 ubiquitin protein ligase 4 "GO:0001650,GO:0004842,GO:0005829,GO:0007283,GO:0016567,GO:0030154,GO:0045879" fibrillar center|ubiquitin-protein transferase activity|cytosol|spermatogenesis|protein ubiquitination|cell differentiation|negative regulation of smoothened signaling pathway hsa04120 Ubiquitin mediated proteolysis HERC5 629.102455 631.5312268 626.6736833 0.992308308 -0.011139662 0.972711232 1 8.371500464 8.168101237 51191 HECT and RLD domain containing E3 ubiquitin protein ligase 5 "GO:0000079,GO:0000209,GO:0003723,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0016567,GO:0018215,GO:0032020,GO:0032480,GO:0042296,GO:0045087,GO:0048471,GO:0050688,GO:0051607,GO:0061630" regulation of cyclin-dependent protein serine/threonine kinase activity|protein polyubiquitination|RNA binding|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|protein ubiquitination|protein phosphopantetheinylation|ISG15-protein conjugation|negative regulation of type I interferon production|ISG15 transferase activity|innate immune response|perinuclear region of cytoplasm|regulation of defense response to virus|defense response to virus|ubiquitin protein ligase activity HERC6 231.1070889 225.7698125 236.4443652 1.047280691 0.066648163 0.85861472 1 2.883206496 2.968998804 55008 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 "GO:0000209,GO:0004842,GO:0005654,GO:0005829" protein polyubiquitination|ubiquitin-protein transferase activity|nucleoplasm|cytosol HERPUD1 971.9703623 990.4740163 953.4667083 0.962636771 -0.054936563 0.827325394 1 18.52778753 17.53707612 9709 homocysteine inducible ER protein with ubiquitin like domain 1 "GO:0003674,GO:0005515,GO:0005783,GO:0005789,GO:0006511,GO:0006986,GO:0016020,GO:0016021,GO:0016567,GO:0030433,GO:0030968,GO:0030970,GO:0031396,GO:0032469,GO:0034976,GO:0036499,GO:0043154,GO:0044322,GO:0044325,GO:0045047,GO:1902236,GO:1903069,GO:1903071,GO:1990037,GO:1990756,GO:2001243" "molecular_function|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|ubiquitin-dependent protein catabolic process|response to unfolded protein|membrane|integral component of membrane|protein ubiquitination|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|retrograde protein transport, ER to cytosol|regulation of protein ubiquitination|endoplasmic reticulum calcium ion homeostasis|response to endoplasmic reticulum stress|PERK-mediated unfolded protein response|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|endoplasmic reticulum quality control compartment|ion channel binding|protein targeting to ER|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|regulation of ER-associated ubiquitin-dependent protein catabolic process|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|Lewy body core|ubiquitin ligase-substrate adaptor activity|negative regulation of intrinsic apoptotic signaling pathway" hsa04141 Protein processing in endoplasmic reticulum HERPUD2 686.0383694 662.7436432 709.3330955 1.070297849 0.098012334 0.706985168 1 9.954801624 10.47631241 64224 HERPUD family member 2 "GO:0005515,GO:0007283,GO:0016021,GO:0030968" protein binding|spermatogenesis|integral component of membrane|endoplasmic reticulum unfolded protein response HES1 123.8494954 147.7387713 99.96021942 0.676601129 -0.563622511 0.194721449 1 5.006061393 3.330428143 3280 hes family bHLH transcription factor 1 "GO:0000122,GO:0000978,GO:0000981,GO:0001085,GO:0001227,GO:0001889,GO:0003143,GO:0003151,GO:0003266,GO:0003281,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007155,GO:0007219,GO:0007224,GO:0007399,GO:0008134,GO:0008284,GO:0009952,GO:0016477,GO:0021537,GO:0021555,GO:0021557,GO:0021558,GO:0021575,GO:0021861,GO:0021984,GO:0030324,GO:0030513,GO:0030901,GO:0031016,GO:0032991,GO:0035019,GO:0035910,GO:0042102,GO:0042531,GO:0042803,GO:0042826,GO:0043388,GO:0043398,GO:0043433,GO:0043565,GO:0045598,GO:0045608,GO:0045665,GO:0045747,GO:0045892,GO:0045893,GO:0045944,GO:0045977,GO:0046331,GO:0046425,GO:0046427,GO:0048469,GO:0048538,GO:0048667,GO:0048711,GO:0048715,GO:0048844,GO:0050678,GO:0050767,GO:0051087,GO:0060122,GO:0060164,GO:0060253,GO:0060412,GO:0060675,GO:0060716,GO:0061009,GO:0061106,GO:0061309,GO:0061626,GO:0065003,GO:0070888,GO:0071820,GO:0072012,GO:0072049,GO:0072050,GO:0072141,GO:0072282,GO:0090102,GO:0090162,GO:0097084,GO:0097150,GO:1905934,GO:1990837,GO:2000227,GO:2000737,GO:2000974,GO:2000978" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|liver development|embryonic heart tube morphogenesis|outflow tract morphogenesis|regulation of secondary heart field cardioblast proliferation|ventricular septum development|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|cell adhesion|Notch signaling pathway|smoothened signaling pathway|nervous system development|transcription factor binding|positive regulation of cell population proliferation|anterior/posterior pattern specification|cell migration|telencephalon development|midbrain-hindbrain boundary morphogenesis|oculomotor nerve development|trochlear nerve development|hindbrain morphogenesis|forebrain radial glial cell differentiation|adenohypophysis development|lung development|positive regulation of BMP signaling pathway|midbrain development|pancreas development|protein-containing complex|somatic stem cell population maintenance|ascending aorta morphogenesis|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|protein homodimerization activity|histone deacetylase binding|positive regulation of DNA binding|HLH domain binding|negative regulation of DNA-binding transcription factor activity|sequence-specific DNA binding|regulation of fat cell differentiation|negative regulation of inner ear auditory receptor cell differentiation|negative regulation of neuron differentiation|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of mitotic cell cycle, embryonic|lateral inhibition|regulation of receptor signaling pathway via JAK-STAT|positive regulation of receptor signaling pathway via JAK-STAT|cell maturation|thymus development|cell morphogenesis involved in neuron differentiation|positive regulation of astrocyte differentiation|negative regulation of oligodendrocyte differentiation|artery morphogenesis|regulation of epithelial cell proliferation|regulation of neurogenesis|chaperone binding|inner ear receptor cell stereocilium organization|regulation of timing of neuron differentiation|negative regulation of glial cell proliferation|ventricular septum morphogenesis|ureteric bud morphogenesis|labyrinthine layer blood vessel development|common bile duct development|negative regulation of stomach neuroendocrine cell differentiation|cardiac neural crest cell development involved in outflow tract morphogenesis|pharyngeal arch artery morphogenesis|protein-containing complex assembly|E-box binding|N-box binding|glomerulus vasculature development|comma-shaped body morphogenesis|S-shaped body morphogenesis|renal interstitial fibroblast development|metanephric nephron tubule morphogenesis|cochlea development|establishment of epithelial cell polarity|vascular associated smooth muscle cell development|neuronal stem cell population maintenance|negative regulation of cell fate determination|sequence-specific double-stranded DNA binding|negative regulation of pancreatic A cell differentiation|negative regulation of stem cell differentiation|negative regulation of pro-B cell differentiation|negative regulation of forebrain neuron differentiation" "hsa03460,hsa04330,hsa04950,hsa05165,hsa05169,hsa05200,hsa05224" Fanconi anemia pathway|Notch signaling pathway|Maturity onset diabetes of the young|Human papillomavirus infection|Epstein-Barr virus infection|Pathways in cancer|Breast cancer bHLH HES4 262.3496878 213.2848459 311.4145297 1.460087464 0.546054793 0.097657852 1 11.79546138 16.93421165 57801 hes family bHLH transcription factor 4 "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0007399,GO:0008134,GO:0009952,GO:0030154,GO:0046983" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|nervous system development|transcription factor binding|anterior/posterior pattern specification|cell differentiation|protein dimerization activity" hsa05165 Human papillomavirus infection bHLH HES6 108.7634941 117.5667687 99.96021942 0.850242126 -0.234054354 0.617841029 1 4.58649296 3.834374507 55502 hes family bHLH transcription factor 6 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005667,GO:0006355,GO:0006357,GO:0008134,GO:0009952,GO:0043433,GO:0046983,GO:0050767,GO:0061629,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|transcription regulator complex|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription factor binding|anterior/posterior pattern specification|negative regulation of DNA-binding transcription factor activity|protein dimerization activity|regulation of neurogenesis|RNA polymerase II-specific DNA-binding transcription factor binding|sequence-specific double-stranded DNA binding" hsa05165 Human papillomavirus infection HES7 80.38485567 79.07145508 81.69825626 1.0332206 0.047148313 0.952530081 1 1.597841057 1.623296346 84667 hes family bHLH transcription factor 7 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001501,GO:0001756,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0007219,GO:0007498,GO:0008134,GO:0009952,GO:0036342,GO:0046983,GO:0048511,GO:0050767,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|skeletal system development|somitogenesis|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|Notch signaling pathway|mesoderm development|transcription factor binding|anterior/posterior pattern specification|post-anal tail morphogenesis|protein dimerization activity|rhythmic process|regulation of neurogenesis|sequence-specific double-stranded DNA binding" hsa05165 Human papillomavirus infection HESX1 46.75445805 54.1015219 39.4073942 0.728397147 -0.457202823 0.468134946 1 1.447267564 1.036545196 8820 HESX homeobox 1 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0006357,GO:0007420,GO:0008022,GO:0008406,GO:0010467,GO:0021983,GO:0030878,GO:0030916,GO:0035264,GO:0043010,GO:0043584,GO:0045995,GO:0047485,GO:0048853,GO:0048861,GO:0048863,GO:0060070,GO:0070371,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|chromatin binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|brain development|protein C-terminus binding|gonad development|gene expression|pituitary gland development|thyroid gland development|otic vesicle formation|multicellular organism growth|camera-type eye development|nose development|regulation of embryonic development|protein N-terminus binding|forebrain morphogenesis|leukemia inhibitory factor signaling pathway|stem cell differentiation|canonical Wnt signaling pathway|ERK1 and ERK2 cascade|sequence-specific double-stranded DNA binding" hsa04550 Signaling pathways regulating pluripotency of stem cells HEXA 2213.637476 2248.3344 2178.940552 0.969135442 -0.045229791 0.849974438 1 24.90441567 23.73187276 3073 hexosaminidase subunit alpha "GO:0004563,GO:0005515,GO:0005829,GO:0005975,GO:0006024,GO:0006687,GO:0006689,GO:0008375,GO:0016020,GO:0030207,GO:0030214,GO:0042340,GO:0042582,GO:0043202,GO:0043231,GO:0046982,GO:0070062,GO:0102148" beta-N-acetylhexosaminidase activity|protein binding|cytosol|carbohydrate metabolic process|glycosaminoglycan biosynthetic process|glycosphingolipid metabolic process|ganglioside catabolic process|acetylglucosaminyltransferase activity|membrane|chondroitin sulfate catabolic process|hyaluronan catabolic process|keratan sulfate catabolic process|azurophil granule|lysosomal lumen|intracellular membrane-bounded organelle|protein heterodimerization activity|extracellular exosome|N-acetyl-beta-D-galactosaminidase activity "hsa00511,hsa00513,hsa00520,hsa00531,hsa00603,hsa00604,hsa04142" Other glycan degradation|Various types of N-glycan biosynthesis|Amino sugar and nucleotide sugar metabolism|Glycosaminoglycan degradation|Glycosphingolipid biosynthesis - globo and isoglobo series|Glycosphingolipid biosynthesis - ganglio series|Lysosome HEXB 4664.931496 4768.216824 4561.646167 0.956677587 -0.063895295 0.790161924 1 108.3777548 101.9475816 3074 hexosaminidase subunit beta "GO:0001501,GO:0001669,GO:0004563,GO:0005515,GO:0005576,GO:0006687,GO:0006689,GO:0006874,GO:0007040,GO:0007341,GO:0007605,GO:0007626,GO:0008049,GO:0008360,GO:0008375,GO:0008654,GO:0009313,GO:0016020,GO:0019915,GO:0030207,GO:0030214,GO:0035578,GO:0042340,GO:0042552,GO:0042582,GO:0042802,GO:0043202,GO:0043312,GO:0043615,GO:0044267,GO:0045944,GO:0048477,GO:0050885,GO:0070062,GO:0102148" skeletal system development|acrosomal vesicle|beta-N-acetylhexosaminidase activity|protein binding|extracellular region|glycosphingolipid metabolic process|ganglioside catabolic process|cellular calcium ion homeostasis|lysosome organization|penetration of zona pellucida|sensory perception of sound|locomotory behavior|male courtship behavior|regulation of cell shape|acetylglucosaminyltransferase activity|phospholipid biosynthetic process|oligosaccharide catabolic process|membrane|lipid storage|chondroitin sulfate catabolic process|hyaluronan catabolic process|azurophil granule lumen|keratan sulfate catabolic process|myelination|azurophil granule|identical protein binding|lysosomal lumen|neutrophil degranulation|astrocyte cell migration|cellular protein metabolic process|positive regulation of transcription by RNA polymerase II|oogenesis|neuromuscular process controlling balance|extracellular exosome|N-acetyl-beta-D-galactosaminidase activity "hsa00511,hsa00513,hsa00520,hsa00531,hsa00603,hsa00604,hsa04142" Other glycan degradation|Various types of N-glycan biosynthesis|Amino sugar and nucleotide sugar metabolism|Glycosaminoglycan degradation|Glycosphingolipid biosynthesis - globo and isoglobo series|Glycosphingolipid biosynthesis - ganglio series|Lysosome HEXD 146.5108879 162.3045657 130.71721 0.805382211 -0.312254488 0.450529707 1 3.056420737 2.420395569 284004 hexosaminidase D "GO:0004563,GO:0005634,GO:0005737,GO:0005975,GO:0015929,GO:0102148,GO:1903561" beta-N-acetylhexosaminidase activity|nucleus|cytoplasm|carbohydrate metabolic process|hexosaminidase activity|N-acetyl-beta-D-galactosaminidase activity|extracellular vesicle "hsa00511,hsa00513" Other glycan degradation|Various types of N-glycan biosynthesis HEXIM1 949.2693409 974.867808 923.6708737 0.947483203 -0.077827727 0.756003272 1 14.35224915 13.37096227 10614 HEXIM P-TEFb complex subunit 1 "GO:0000122,GO:0002218,GO:0004860,GO:0004861,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007507,GO:0017069,GO:0032897,GO:0034244,GO:0042802,GO:0043231,GO:0045087,GO:0045736,GO:0045892,GO:0097322,GO:0106140,GO:0120259,GO:1901798" "negative regulation of transcription by RNA polymerase II|activation of innate immune response|protein kinase inhibitor activity|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|heart development|snRNA binding|negative regulation of viral transcription|negative regulation of transcription elongation from RNA polymerase II promoter|identical protein binding|intracellular membrane-bounded organelle|innate immune response|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|7SK snRNA binding|P-TEFb complex binding|7SK snRNP|positive regulation of signal transduction by p53 class mediator" other HEXIM2 189.6735871 185.1936711 194.1535031 1.048380876 0.068162942 0.868012294 1 3.813057815 3.930643525 124790 HEXIM P-TEFb complex subunit 2 "GO:0000122,GO:0004861,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016607,GO:0017069,GO:0042802,GO:0045736,GO:0045892,GO:0097322" "negative regulation of transcription by RNA polymerase II|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|nuclear speck|snRNA binding|identical protein binding|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|7SK snRNA binding" HEY1 204.422435 256.982229 151.862641 0.590946081 -0.758901593 0.035195356 0.95006405 5.525652397 3.210721206 23462 hes related family bHLH transcription factor with YRPW motif 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001525,GO:0003184,GO:0003190,GO:0003203,GO:0003208,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007219,GO:0008134,GO:0009952,GO:0010628,GO:0035912,GO:0036304,GO:0045665,GO:0045746,GO:0045892,GO:0045893,GO:0045944,GO:0046983,GO:0050767,GO:0060317,GO:0060347,GO:0060411,GO:0060412,GO:0060716,GO:0060842,GO:0061314,GO:0070168,GO:0071385,GO:0072359,GO:1990837,GO:2000678,GO:2000820,GO:2001212" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|angiogenesis|pulmonary valve morphogenesis|atrioventricular valve formation|endocardial cushion morphogenesis|cardiac ventricle morphogenesis|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|Notch signaling pathway|transcription factor binding|anterior/posterior pattern specification|positive regulation of gene expression|dorsal aorta morphogenesis|umbilical cord morphogenesis|negative regulation of neuron differentiation|negative regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|regulation of neurogenesis|cardiac epithelial to mesenchymal transition|heart trabecula formation|cardiac septum morphogenesis|ventricular septum morphogenesis|labyrinthine layer blood vessel development|arterial endothelial cell differentiation|Notch signaling involved in heart development|negative regulation of biomineral tissue development|cellular response to glucocorticoid stimulus|circulatory system development|sequence-specific double-stranded DNA binding|negative regulation of transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|regulation of vasculogenesis" "hsa04330,hsa05165,hsa05200,hsa05224" Notch signaling pathway|Human papillomavirus infection|Pathways in cancer|Breast cancer bHLH HEY2 5.524131538 6.242483296 4.80577978 0.769850643 -0.377349516 0.927604977 1 0.062317595 0.04717244 23493 hes related family bHLH transcription factor with YRPW motif 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001102,GO:0001227,GO:0001570,GO:0003150,GO:0003151,GO:0003180,GO:0003184,GO:0003186,GO:0003195,GO:0003198,GO:0003199,GO:0003208,GO:0003214,GO:0003215,GO:0003222,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007219,GO:0008134,GO:0009948,GO:0009952,GO:0010460,GO:0010621,GO:0010628,GO:0010629,GO:0010667,GO:0014031,GO:0014898,GO:0016580,GO:0017053,GO:0035910,GO:0035912,GO:0036304,GO:0042802,GO:0042826,GO:0043565,GO:0045165,GO:0045607,GO:0045746,GO:0045892,GO:0045893,GO:0045944,GO:0046983,GO:0050767,GO:0051145,GO:0055015,GO:0060045,GO:0060317,GO:0060347,GO:0060411,GO:0060412,GO:0060413,GO:0060633,GO:0060716,GO:0060842,GO:0060948,GO:0060977,GO:0061156,GO:0061314,GO:0065004,GO:0070168,GO:0072359,GO:0090102,GO:0097084,GO:1990837,GO:2000678,GO:2000723,GO:2000820,GO:2001212" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II activating transcription factor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|vasculogenesis|muscular septum morphogenesis|outflow tract morphogenesis|aortic valve morphogenesis|pulmonary valve morphogenesis|tricuspid valve morphogenesis|tricuspid valve formation|epithelial to mesenchymal transition involved in endocardial cushion formation|endocardial cushion to mesenchymal transition involved in heart valve formation|cardiac ventricle morphogenesis|cardiac left ventricle morphogenesis|cardiac right ventricle morphogenesis|ventricular trabecula myocardium morphogenesis|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|Notch signaling pathway|transcription factor binding|anterior/posterior axis specification|anterior/posterior pattern specification|positive regulation of heart rate|negative regulation of transcription by transcription factor localization|positive regulation of gene expression|negative regulation of gene expression|negative regulation of cardiac muscle cell apoptotic process|mesenchymal cell development|cardiac muscle hypertrophy in response to stress|Sin3 complex|transcription repressor complex|ascending aorta morphogenesis|dorsal aorta morphogenesis|umbilical cord morphogenesis|identical protein binding|histone deacetylase binding|sequence-specific DNA binding|cell fate commitment|regulation of inner ear auditory receptor cell differentiation|negative regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|regulation of neurogenesis|smooth muscle cell differentiation|ventricular cardiac muscle cell development|positive regulation of cardiac muscle cell proliferation|cardiac epithelial to mesenchymal transition|heart trabecula formation|cardiac septum morphogenesis|ventricular septum morphogenesis|atrial septum morphogenesis|negative regulation of transcription initiation from RNA polymerase II promoter|labyrinthine layer blood vessel development|arterial endothelial cell differentiation|cardiac vascular smooth muscle cell development|coronary vasculature morphogenesis|pulmonary artery morphogenesis|Notch signaling involved in heart development|protein-DNA complex assembly|negative regulation of biomineral tissue development|circulatory system development|cochlea development|vascular associated smooth muscle cell development|sequence-specific double-stranded DNA binding|negative regulation of transcription regulatory region DNA binding|negative regulation of cardiac vascular smooth muscle cell differentiation|negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|regulation of vasculogenesis" "hsa04330,hsa05165,hsa05200,hsa05224" Notch signaling pathway|Human papillomavirus infection|Pathways in cancer|Breast cancer HFE 282.0477401 326.6899591 237.4055211 0.726699779 -0.460568627 0.15250177 1 3.368400829 2.40685525 3077 homeostatic iron regulator "GO:0002474,GO:0002626,GO:0002725,GO:0005102,GO:0005515,GO:0005615,GO:0005654,GO:0005769,GO:0005886,GO:0005887,GO:0006879,GO:0006953,GO:0007565,GO:0009897,GO:0010039,GO:0010106,GO:0010628,GO:0010862,GO:0019882,GO:0030509,GO:0030881,GO:0031410,GO:0032092,GO:0032435,GO:0033572,GO:0034756,GO:0039706,GO:0042605,GO:0042612,GO:0045177,GO:0045178,GO:0048260,GO:0048471,GO:0055037,GO:0055072,GO:0065003,GO:0071281,GO:0090277,GO:0097421,GO:0098711,GO:1900121,GO:1900122,GO:1904283,GO:1904434,GO:1904437,GO:1990357,GO:1990459,GO:1990641,GO:1990712,GO:2000008,GO:2000059,GO:2000272,GO:2000273,GO:2001186" "antigen processing and presentation of peptide antigen via MHC class I|negative regulation of T cell antigen processing and presentation|negative regulation of T cell cytokine production|signaling receptor binding|protein binding|extracellular space|nucleoplasm|early endosome|plasma membrane|integral component of plasma membrane|cellular iron ion homeostasis|acute-phase response|female pregnancy|external side of plasma membrane|response to iron ion|cellular response to iron ion starvation|positive regulation of gene expression|positive regulation of pathway-restricted SMAD protein phosphorylation|antigen processing and presentation|BMP signaling pathway|beta-2-microglobulin binding|cytoplasmic vesicle|positive regulation of protein binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|transferrin transport|regulation of iron ion transport|co-receptor binding|peptide antigen binding|MHC class I protein complex|apical part of cell|basal part of cell|positive regulation of receptor-mediated endocytosis|perinuclear region of cytoplasm|recycling endosome|iron ion homeostasis|protein-containing complex assembly|cellular response to iron ion|positive regulation of peptide hormone secretion|liver regeneration|iron ion import across plasma membrane|negative regulation of receptor binding|positive regulation of receptor binding|negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I|positive regulation of ferrous iron binding|positive regulation of transferrin receptor binding|terminal web|transferrin receptor binding|response to iron ion starvation|HFE-transferrin receptor complex|regulation of protein localization to cell surface|negative regulation of ubiquitin-dependent protein catabolic process|negative regulation of signaling receptor activity|positive regulation of signaling receptor activity|negative regulation of CD8-positive, alpha-beta T cell activation" HFM1 4.364830765 1.040413883 7.689247648 7.390566174 2.88568489 0.162518845 1 0.010335997 0.075110607 164045 helicase for meiosis 1 "GO:0000712,GO:0003678,GO:0003729,GO:0005524,GO:0006417,GO:0010494,GO:0032508" resolution of meiotic recombination intermediates|DNA helicase activity|mRNA binding|ATP binding|regulation of translation|cytoplasmic stress granule|DNA duplex unwinding HGD 13.53041089 14.56579436 12.49502743 0.857833574 -0.221230314 0.898154764 1 0.30896251 0.260603355 3081 "homogentisate 1,2-dioxygenase" "GO:0004411,GO:0005515,GO:0005737,GO:0005829,GO:0006559,GO:0006572,GO:0042802,GO:0046872,GO:0055114,GO:0070062" "homogentisate 1,2-dioxygenase activity|protein binding|cytoplasm|cytosol|L-phenylalanine catabolic process|tyrosine catabolic process|identical protein binding|metal ion binding|oxidation-reduction process|extracellular exosome" hsa00350 Tyrosine metabolism HGH1 480.3667004 524.3685969 436.364804 0.832171886 -0.265046546 0.337854077 1 11.04364178 9.036422515 51236 HGH1 homolog "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process HGS 3975.366149 4012.876345 3937.855952 0.981305082 -0.027226363 0.909990059 1 74.02690467 71.42739591 9146 hepatocyte growth factor-regulated tyrosine kinase substrate "GO:0005515,GO:0005764,GO:0005768,GO:0005769,GO:0005829,GO:0006622,GO:0007165,GO:0008285,GO:0010324,GO:0010628,GO:0010642,GO:0016197,GO:0016236,GO:0016525,GO:0016579,GO:0019904,GO:0030948,GO:0031901,GO:0032585,GO:0033565,GO:0036258,GO:0042059,GO:0042176,GO:0043231,GO:0043405,GO:0044389,GO:0046426,GO:0046872,GO:0061024,GO:0070062,GO:0072657,GO:1903543" protein binding|lysosome|endosome|early endosome|cytosol|protein targeting to lysosome|signal transduction|negative regulation of cell population proliferation|membrane invagination|positive regulation of gene expression|negative regulation of platelet-derived growth factor receptor signaling pathway|endosomal transport|macroautophagy|negative regulation of angiogenesis|protein deubiquitination|protein domain specific binding|negative regulation of vascular endothelial growth factor receptor signaling pathway|early endosome membrane|multivesicular body membrane|ESCRT-0 complex|multivesicular body assembly|negative regulation of epidermal growth factor receptor signaling pathway|regulation of protein catabolic process|intracellular membrane-bounded organelle|regulation of MAP kinase activity|ubiquitin-like protein ligase binding|negative regulation of receptor signaling pathway via JAK-STAT|metal ion binding|membrane organization|extracellular exosome|protein localization to membrane|positive regulation of exosomal secretion "hsa04144,hsa04145" Endocytosis|Phagosome HGSNAT 640.6709251 645.0566072 636.2852429 0.986402179 -0.019752108 0.94588073 1 6.212865108 6.025833478 138050 heparan-alpha-glucosaminide N-acetyltransferase "GO:0005765,GO:0005886,GO:0006027,GO:0007041,GO:0015019,GO:0016021,GO:0016746,GO:0035579,GO:0043312,GO:0051259,GO:0070821" "lysosomal membrane|plasma membrane|glycosaminoglycan catabolic process|lysosomal transport|heparan-alpha-glucosaminide N-acetyltransferase activity|integral component of membrane|transferase activity, transferring acyl groups|specific granule membrane|neutrophil degranulation|protein complex oligomerization|tertiary granule membrane" "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome HHAT 69.0937884 72.82897178 65.35860501 0.897425893 -0.156135286 0.79243116 1 0.889823345 0.785187848 55733 hedgehog acyltransferase "GO:0005515,GO:0005525,GO:0005783,GO:0005789,GO:0007224,GO:0007275,GO:0008374,GO:0016021,GO:0016409,GO:0016746,GO:0018345" "protein binding|GTP binding|endoplasmic reticulum|endoplasmic reticulum membrane|smoothened signaling pathway|multicellular organism development|O-acyltransferase activity|integral component of membrane|palmitoyltransferase activity|transferase activity, transferring acyl groups|protein palmitoylation" HHEX 557.075509 582.6317743 531.5192437 0.912273012 -0.132462457 0.623508171 1 18.03595531 16.17838464 3087 hematopoietically expressed homeobox "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0006406,GO:0008134,GO:0008190,GO:0008301,GO:0009611,GO:0009952,GO:0010621,GO:0010944,GO:0016055,GO:0016525,GO:0016973,GO:0017025,GO:0030154,GO:0030177,GO:0030183,GO:0030948,GO:0032993,GO:0034504,GO:0042803,GO:0043434,GO:0043565,GO:0045736,GO:0045892,GO:0045893,GO:0045944,GO:0070491,GO:0070663,GO:0071103,GO:0090263" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|mRNA export from nucleus|transcription factor binding|eukaryotic initiation factor 4E binding|DNA binding, bending|response to wounding|anterior/posterior pattern specification|negative regulation of transcription by transcription factor localization|negative regulation of transcription by competitive promoter binding|Wnt signaling pathway|negative regulation of angiogenesis|poly(A)+ mRNA export from nucleus|TBP-class protein binding|cell differentiation|positive regulation of Wnt signaling pathway|B cell differentiation|negative regulation of vascular endothelial growth factor receptor signaling pathway|protein-DNA complex|protein localization to nucleus|protein homodimerization activity|response to peptide hormone|sequence-specific DNA binding|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|repressing transcription factor binding|regulation of leukocyte proliferation|DNA conformation change|positive regulation of canonical Wnt signaling pathway" "hsa04950,hsa05202" Maturity onset diabetes of the young|Transcriptional misregulation in cancer HHIPL1 4.523346619 5.202069413 3.844623824 0.739056617 -0.436243205 0.933440272 1 0.030414645 0.022102004 84439 HHIP like 1 "GO:0003674,GO:0003824,GO:0005044,GO:0005575,GO:0005576,GO:0006897,GO:0008150,GO:0016020" molecular_function|catalytic activity|scavenger receptor activity|cellular_component|extracellular region|endocytosis|biological_process|membrane HHIPL2 11.04826308 12.48496659 9.61155956 0.769850643 -0.377349516 0.799003187 1 0.198067693 0.149930952 79802 HHIP like 2 "GO:0003824,GO:0005515,GO:0005576" catalytic activity|protein binding|extracellular region HIBADH 2400.294846 2266.021436 2534.568256 1.118510273 0.161578507 0.494740145 1 61.17015644 67.27454159 11112 3-hydroxyisobutyrate dehydrogenase "GO:0005515,GO:0005739,GO:0005759,GO:0006574,GO:0008442,GO:0009083,GO:0016616,GO:0050661,GO:0051287,GO:0055114" "protein binding|mitochondrion|mitochondrial matrix|valine catabolic process|3-hydroxyisobutyrate dehydrogenase activity|branched-chain amino acid catabolic process|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|NADP binding|NAD binding|oxidation-reduction process" hsa00280 "Valine, leucine and isoleucine degradation" HIBCH 522.3505916 491.0753526 553.6258307 1.127374501 0.172966842 0.525811149 1 10.2614679 11.37493378 26275 3-hydroxyisobutyryl-CoA hydrolase "GO:0003860,GO:0005739,GO:0005759,GO:0006574,GO:0009083" 3-hydroxyisobutyryl-CoA hydrolase activity|mitochondrion|mitochondrial matrix|valine catabolic process|branched-chain amino acid catabolic process "hsa00280,hsa00410,hsa00640" "Valine, leucine and isoleucine degradation|beta-Alanine metabolism|Propanoate metabolism" HIC1 35.66656601 40.57614142 30.75699059 0.758006787 -0.399717329 0.576478547 1 0.678832004 0.505948814 3090 HIC ZBTB transcriptional repressor 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0007275,GO:0008630,GO:0016055,GO:0030178,GO:0042826,GO:0043517,GO:0043565,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|intrinsic apoptotic signaling pathway in response to DNA damage|Wnt signaling pathway|negative regulation of Wnt signaling pathway|histone deacetylase binding|positive regulation of DNA damage response, signal transduction by p53 class mediator|sequence-specific DNA binding|metal ion binding|sequence-specific double-stranded DNA binding" HIC2 203.0058532 194.5573961 211.4543103 1.086847967 0.120150144 0.750378239 1 1.158060523 1.23757416 23119 HIC ZBTB transcriptional repressor 2 "GO:0000122,GO:0000978,GO:0001227,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008022,GO:0045892,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|protein C-terminus binding|negative regulation of transcription, DNA-templated|metal ion binding" HID1 196.6545438 153.9812546 239.327833 1.554266028 0.636233457 0.082165151 1 2.491721211 3.807991606 283987 HID1 domain containing "GO:0000138,GO:0005515,GO:0005737,GO:0005794,GO:0005797,GO:0005829,GO:0005881,GO:0016020,GO:0070062,GO:0090498" Golgi trans cisterna|protein binding|cytoplasm|Golgi apparatus|Golgi medial cisterna|cytosol|cytoplasmic microtubule|membrane|extracellular exosome|extrinsic component of Golgi membrane HIF1A 8908.279061 9230.551967 8586.006155 0.93017256 -0.104429713 0.674830633 1 117.5137389 107.4789331 3091 hypoxia inducible factor 1 subunit alpha "GO:0000302,GO:0000785,GO:0000977,GO:0000981,GO:0001228,GO:0001525,GO:0001666,GO:0001755,GO:0001837,GO:0001892,GO:0001922,GO:0001938,GO:0001947,GO:0002039,GO:0002052,GO:0002248,GO:0002534,GO:0003151,GO:0003208,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006089,GO:0006110,GO:0006355,GO:0006357,GO:0006879,GO:0007165,GO:0007595,GO:0008134,GO:0008542,GO:0010039,GO:0010468,GO:0010573,GO:0010575,GO:0010628,GO:0010629,GO:0010634,GO:0014850,GO:0016239,GO:0016567,GO:0016579,GO:0016604,GO:0016607,GO:0019221,GO:0019896,GO:0019899,GO:0019901,GO:0019904,GO:0021502,GO:0021987,GO:0030502,GO:0030949,GO:0031514,GO:0031625,GO:0032007,GO:0032364,GO:0032722,GO:0032909,GO:0032963,GO:0032991,GO:0035035,GO:0035162,GO:0035257,GO:0035774,GO:0042541,GO:0042593,GO:0042826,GO:0043536,GO:0043565,GO:0043619,GO:0043687,GO:0045648,GO:0045766,GO:0045821,GO:0045893,GO:0045926,GO:0045944,GO:0046716,GO:0046886,GO:0046982,GO:0048546,GO:0051000,GO:0051216,GO:0051541,GO:0051879,GO:0060574,GO:0061030,GO:0061072,GO:0061298,GO:0061418,GO:0061419,GO:0070101,GO:0070244,GO:0070888,GO:0071347,GO:0071456,GO:0071542,GO:0090575,GO:0097411,GO:0098586,GO:1902895,GO:1903377,GO:1903599,GO:1903715,GO:1904115,GO:2000273,GO:2000378,GO:2000434,GO:2001054" "response to reactive oxygen species|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|response to hypoxia|neural crest cell migration|epithelial to mesenchymal transition|embryonic placenta development|B-1 B cell homeostasis|positive regulation of endothelial cell proliferation|heart looping|p53 binding|positive regulation of neuroblast proliferation|connective tissue replacement involved in inflammatory response wound healing|cytokine production involved in inflammatory response|outflow tract morphogenesis|cardiac ventricle morphogenesis|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|lactate metabolic process|regulation of glycolytic process|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|cellular iron ion homeostasis|signal transduction|lactation|transcription factor binding|visual learning|response to iron ion|regulation of gene expression|vascular endothelial growth factor production|positive regulation of vascular endothelial growth factor production|positive regulation of gene expression|negative regulation of gene expression|positive regulation of epithelial cell migration|response to muscle activity|positive regulation of macroautophagy|protein ubiquitination|protein deubiquitination|nuclear body|nuclear speck|cytokine-mediated signaling pathway|axonal transport of mitochondrion|enzyme binding|protein kinase binding|protein domain specific binding|neural fold elevation formation|cerebral cortex development|negative regulation of bone mineralization|positive regulation of vascular endothelial growth factor receptor signaling pathway|motile cilium|ubiquitin protein ligase binding|negative regulation of TOR signaling|oxygen homeostasis|positive regulation of chemokine production|regulation of transforming growth factor beta2 production|collagen metabolic process|protein-containing complex|histone acetyltransferase binding|embryonic hemopoiesis|nuclear hormone receptor binding|positive regulation of insulin secretion involved in cellular response to glucose stimulus|hemoglobin biosynthetic process|glucose homeostasis|histone deacetylase binding|positive regulation of blood vessel endothelial cell migration|sequence-specific DNA binding|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|post-translational protein modification|positive regulation of erythrocyte differentiation|positive regulation of angiogenesis|positive regulation of glycolytic process|positive regulation of transcription, DNA-templated|negative regulation of growth|positive regulation of transcription by RNA polymerase II|muscle cell cellular homeostasis|positive regulation of hormone biosynthetic process|protein heterodimerization activity|digestive tract morphogenesis|positive regulation of nitric-oxide synthase activity|cartilage development|elastin metabolic process|Hsp90 protein binding|intestinal epithelial cell maturation|epithelial cell differentiation involved in mammary gland alveolus development|iris morphogenesis|retina vasculature development in camera-type eye|regulation of transcription from RNA polymerase II promoter in response to hypoxia|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|positive regulation of chemokine-mediated signaling pathway|negative regulation of thymocyte apoptotic process|E-box binding|cellular response to interleukin-1|cellular response to hypoxia|dopaminergic neuron differentiation|RNA polymerase II transcription regulator complex|hypoxia-inducible factor-1alpha signaling pathway|cellular response to virus|positive regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|positive regulation of autophagy of mitochondrion|regulation of aerobic respiration|axon cytoplasm|positive regulation of signaling receptor activity|negative regulation of reactive oxygen species metabolic process|regulation of protein neddylation|negative regulation of mesenchymal cell apoptotic process" "hsa04066,hsa04137,hsa04140,hsa04659,hsa04919,hsa05167,hsa05200,hsa05205,hsa05211,hsa05230,hsa05231,hsa05235" HIF-1 signaling pathway|Mitophagy - animal|Autophagy - animal|Th17 cell differentiation|Thyroid hormone signaling pathway|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Proteoglycans in cancer|Renal cell carcinoma|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer other HIF1AN 3208.616445 3186.787723 3230.445168 1.013699515 0.019630066 0.935347408 1 13.07348787 13.03082419 55662 hypoxia inducible factor 1 subunit alpha inhibitor "GO:0005112,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008198,GO:0008270,GO:0016706,GO:0018215,GO:0019826,GO:0031406,GO:0036138,GO:0036139,GO:0036140,GO:0042264,GO:0042265,GO:0042803,GO:0045663,GO:0045746,GO:0048471,GO:0051059,GO:0055114,GO:0061418,GO:0061428,GO:0071532,GO:0102113,GO:2001214" Notch binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|ferrous iron binding|zinc ion binding|2-oxoglutarate-dependent dioxygenase activity|protein phosphopantetheinylation|oxygen sensor activity|carboxylic acid binding|peptidyl-histidine hydroxylation|peptidyl-histidine dioxygenase activity|peptidyl-asparagine 3-dioxygenase activity|peptidyl-aspartic acid hydroxylation|peptidyl-asparagine hydroxylation|protein homodimerization activity|positive regulation of myoblast differentiation|negative regulation of Notch signaling pathway|perinuclear region of cytoplasm|NF-kappaB binding|oxidation-reduction process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of transcription from RNA polymerase II promoter in response to hypoxia|ankyrin repeat binding|hypoxia-inducible factor-asparagine oxygenase activity|positive regulation of vasculogenesis HIGD1A 2505.889252 2098.514801 2913.263703 1.388250252 0.473267658 0.045483452 1 37.50632218 51.19687107 25994 HIG1 hypoxia inducible domain family member 1A "GO:0005654,GO:0005739,GO:0005743,GO:0016021,GO:0032991,GO:0043066,GO:0055114,GO:0061418,GO:0070469,GO:0097250" nucleoplasm|mitochondrion|mitochondrial inner membrane|integral component of membrane|protein-containing complex|negative regulation of apoptotic process|oxidation-reduction process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|respirasome|mitochondrial respirasome assembly HIGD2A 767.6076779 684.5923348 850.6230211 1.242524898 0.313274761 0.215781926 1 55.86457902 68.25159563 192286 HIG1 hypoxia inducible domain family member 2A "GO:0005739,GO:0005743,GO:0016021,GO:0043066,GO:0055114,GO:0070469,GO:0097250" mitochondrion|mitochondrial inner membrane|integral component of membrane|negative regulation of apoptotic process|oxidation-reduction process|respirasome|mitochondrial respirasome assembly HIKESHI 660.1173411 587.8338437 732.4008385 1.245931731 0.31722502 0.220221982 1 18.45388932 22.60754149 51501 heat shock protein nuclear import factor hikeshi "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006606,GO:0007030,GO:0015031,GO:0016604,GO:0016607,GO:0030324,GO:0030544,GO:0034605,GO:0061608,GO:1900034" protein binding|nucleus|nucleoplasm|cytosol|protein import into nucleus|Golgi organization|protein transport|nuclear body|nuclear speck|lung development|Hsp70 protein binding|cellular response to heat|nuclear import signal receptor activity|regulation of cellular response to heat HILPDA 320.4644103 300.6796121 340.2492084 1.13160053 0.178364758 0.568111558 1 12.83737462 14.28369393 29923 hypoxia inducible lipid droplet associated "GO:0001819,GO:0005102,GO:0005515,GO:0005615,GO:0005654,GO:0005811,GO:0005829,GO:0008284,GO:0009986,GO:0010884,GO:0016021,GO:0030141,GO:0034389,GO:0035425,GO:0071456" positive regulation of cytokine production|signaling receptor binding|protein binding|extracellular space|nucleoplasm|lipid droplet|cytosol|positive regulation of cell population proliferation|cell surface|positive regulation of lipid storage|integral component of membrane|secretory granule|lipid droplet organization|autocrine signaling|cellular response to hypoxia HINFP 406.848945 398.4785171 415.219373 1.042011941 0.05937181 0.844608414 1 6.816046821 6.983553096 25988 histone H4 transcription factor "GO:0000077,GO:0000082,GO:0000083,GO:0000122,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0001701,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006281,GO:0006351,GO:0006355,GO:0006357,GO:0010468,GO:0010628,GO:0010629,GO:0015030,GO:0019899,GO:0042393,GO:0045184,GO:0045445,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0048856" "DNA damage checkpoint|G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|in utero embryonic development|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|DNA repair|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|regulation of gene expression|positive regulation of gene expression|negative regulation of gene expression|Cajal body|enzyme binding|histone binding|establishment of protein localization|myoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|anatomical structure development" zf-C2H2 HINT1 3422.11134 3290.829111 3553.393569 1.079786719 0.110746378 0.641227295 1 206.1332176 218.8553373 3094 histidine triad nucleotide binding protein 1 "GO:0000118,GO:0000166,GO:0005080,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006355,GO:0007165,GO:0009154,GO:0016787,GO:0043530,GO:0070062,GO:0072332" "histone deacetylase complex|nucleotide binding|protein kinase C binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|plasma membrane|regulation of transcription, DNA-templated|signal transduction|purine ribonucleotide catabolic process|hydrolase activity|adenosine 5'-monophosphoramidase activity|extracellular exosome|intrinsic apoptotic signaling pathway by p53 class mediator" HINT2 430.9174729 399.5189309 462.3160148 1.157181748 0.210615473 0.460396175 1 28.20316278 32.09006284 84681 histidine triad nucleotide binding protein 2 "GO:0000166,GO:0005737,GO:0005739,GO:0006694,GO:0006915,GO:0016042,GO:0016787,GO:2000757" nucleotide binding|cytoplasm|mitochondrion|steroid biosynthetic process|apoptotic process|lipid catabolic process|hydrolase activity|negative regulation of peptidyl-lysine acetylation HINT3 529.2567065 546.2172884 512.2961245 0.937898041 -0.092497 0.737051502 1 8.767101587 8.085052532 135114 histidine triad nucleotide binding protein 3 "GO:0000166,GO:0005634,GO:0005737,GO:0042802,GO:0043530" nucleotide binding|nucleus|cytoplasm|identical protein binding|adenosine 5'-monophosphoramidase activity HIP1 2516.880952 2450.174694 2583.58721 1.054450206 0.076490968 0.747444648 1 15.4838745 16.05376484 3092 huntingtin interacting protein 1 "GO:0005154,GO:0005200,GO:0005515,GO:0005546,GO:0005634,GO:0005737,GO:0005794,GO:0005829,GO:0005856,GO:0006915,GO:0006919,GO:0007015,GO:0016020,GO:0030100,GO:0030136,GO:0030154,GO:0030276,GO:0030665,GO:0031234,GO:0032051,GO:0032266,GO:0035091,GO:0035254,GO:0035612,GO:0035615,GO:0042803,GO:0042981,GO:0043231,GO:0043325,GO:0045742,GO:0046982,GO:0048260,GO:0048268,GO:0050821,GO:0051015,GO:0051897,GO:0061024,GO:0072583,GO:0080025,GO:0097190,GO:0098793,GO:0098794,GO:0098888,GO:0098890,GO:0098978,GO:0099637,GO:2000588" "epidermal growth factor receptor binding|structural constituent of cytoskeleton|protein binding|phosphatidylinositol-4,5-bisphosphate binding|nucleus|cytoplasm|Golgi apparatus|cytosol|cytoskeleton|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|actin filament organization|membrane|regulation of endocytosis|clathrin-coated vesicle|cell differentiation|clathrin binding|clathrin-coated vesicle membrane|extrinsic component of cytoplasmic side of plasma membrane|clathrin light chain binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol binding|glutamate receptor binding|AP-2 adaptor complex binding|clathrin adaptor activity|protein homodimerization activity|regulation of apoptotic process|intracellular membrane-bounded organelle|phosphatidylinositol-3,4-bisphosphate binding|positive regulation of epidermal growth factor receptor signaling pathway|protein heterodimerization activity|positive regulation of receptor-mediated endocytosis|clathrin coat assembly|protein stabilization|actin filament binding|positive regulation of protein kinase B signaling|membrane organization|clathrin-dependent endocytosis|phosphatidylinositol-3,5-bisphosphate binding|apoptotic signaling pathway|presynapse|postsynapse|extrinsic component of presynaptic membrane|extrinsic component of postsynaptic membrane|glutamatergic synapse|neurotransmitter receptor transport|positive regulation of platelet-derived growth factor receptor-beta signaling pathway" "hsa05016,hsa05022" Huntington disease|Pathways of neurodegeneration - multiple diseases HIP1R 978.3613006 1032.090572 924.6320297 0.895882644 -0.158618337 0.521189327 1 10.92222425 9.621291892 9026 huntingtin interacting protein 1 related "GO:0005515,GO:0005546,GO:0005547,GO:0005739,GO:0005829,GO:0005856,GO:0005886,GO:0005905,GO:0005938,GO:0006898,GO:0006915,GO:0006919,GO:0007015,GO:0014069,GO:0016324,GO:0017124,GO:0030100,GO:0030136,GO:0030276,GO:0030665,GO:0030837,GO:0032051,GO:0032092,GO:0032587,GO:0032839,GO:0032956,GO:0034316,GO:0035091,GO:0035615,GO:0042802,GO:0042803,GO:0043025,GO:0043065,GO:0043066,GO:0043197,GO:0043231,GO:0043325,GO:0045742,GO:0046982,GO:0048260,GO:0048268,GO:0048471,GO:0050821,GO:0051015,GO:0055123,GO:0060453,GO:0061024,GO:0080025,GO:0097060,GO:1901030,GO:1905445,GO:2000369,GO:2000588" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|mitochondrion|cytosol|cytoskeleton|plasma membrane|clathrin-coated pit|cell cortex|receptor-mediated endocytosis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|actin filament organization|postsynaptic density|apical plasma membrane|SH3 domain binding|regulation of endocytosis|clathrin-coated vesicle|clathrin binding|clathrin-coated vesicle membrane|negative regulation of actin filament polymerization|clathrin light chain binding|positive regulation of protein binding|ruffle membrane|dendrite cytoplasm|regulation of actin cytoskeleton organization|negative regulation of Arp2/3 complex-mediated actin nucleation|phosphatidylinositol binding|clathrin adaptor activity|identical protein binding|protein homodimerization activity|neuronal cell body|positive regulation of apoptotic process|negative regulation of apoptotic process|dendritic spine|intracellular membrane-bounded organelle|phosphatidylinositol-3,4-bisphosphate binding|positive regulation of epidermal growth factor receptor signaling pathway|protein heterodimerization activity|positive regulation of receptor-mediated endocytosis|clathrin coat assembly|perinuclear region of cytoplasm|protein stabilization|actin filament binding|digestive system development|regulation of gastric acid secretion|membrane organization|phosphatidylinositol-3,5-bisphosphate binding|synaptic membrane|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of clathrin coat assembly|regulation of clathrin-dependent endocytosis|positive regulation of platelet-derived growth factor receptor-beta signaling pathway" HIPK1 1521.073576 1679.228007 1362.919146 0.811634358 -0.301098156 0.206755179 1 10.16645632 8.113368486 204851 homeodomain interacting protein kinase 1 "GO:0001654,GO:0004674,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006468,GO:0007224,GO:0008284,GO:0009952,GO:0010803,GO:0010842,GO:0016605,GO:0016607,GO:0018105,GO:0018107,GO:0018108,GO:0030182,GO:0034333,GO:0042771,GO:0045766,GO:0048596,GO:0060059,GO:0060216,GO:0060235,GO:0061072,GO:0072577,GO:0097191,GO:0106310,GO:0106311,GO:1901796" eye development|protein serine/threonine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|protein phosphorylation|smoothened signaling pathway|positive regulation of cell population proliferation|anterior/posterior pattern specification|regulation of tumor necrosis factor-mediated signaling pathway|retina layer formation|PML body|nuclear speck|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|neuron differentiation|adherens junction assembly|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of angiogenesis|embryonic camera-type eye morphogenesis|embryonic retina morphogenesis in camera-type eye|definitive hemopoiesis|lens induction in camera-type eye|iris morphogenesis|endothelial cell apoptotic process|extrinsic apoptotic signaling pathway|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator hsa04218 Cellular senescence HIPK2 3128.973865 3253.374211 3004.573518 0.923525338 -0.114776551 0.628599516 1 10.29997047 9.353108525 28996 homeodomain interacting protein kinase 2 "GO:0000122,GO:0001102,GO:0001654,GO:0001934,GO:0003713,GO:0003714,GO:0004672,GO:0004674,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006468,GO:0006978,GO:0007179,GO:0007224,GO:0007628,GO:0008284,GO:0009952,GO:0010842,GO:0016604,GO:0016605,GO:0018105,GO:0018107,GO:0018108,GO:0019048,GO:0030182,GO:0030218,GO:0030511,GO:0030514,GO:0030578,GO:0032092,GO:0042771,GO:0043388,GO:0043524,GO:0045766,GO:0045893,GO:0045944,GO:0046330,GO:0046332,GO:0046790,GO:0048596,GO:0050882,GO:0051091,GO:0051726,GO:0060059,GO:0060235,GO:0060395,GO:0061072,GO:0071456,GO:0090575,GO:0097193,GO:0106310,GO:0106311,GO:1901796,GO:2000059" "negative regulation of transcription by RNA polymerase II|RNA polymerase II activating transcription factor binding|eye development|positive regulation of protein phosphorylation|transcription coactivator activity|transcription corepressor activity|protein kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|transforming growth factor beta receptor signaling pathway|smoothened signaling pathway|adult walking behavior|positive regulation of cell population proliferation|anterior/posterior pattern specification|retina layer formation|nuclear body|PML body|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|modulation by virus of host process|neuron differentiation|erythrocyte differentiation|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|PML body organization|positive regulation of protein binding|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of DNA binding|negative regulation of neuron apoptotic process|positive regulation of angiogenesis|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|SMAD binding|virion binding|embryonic camera-type eye morphogenesis|voluntary musculoskeletal movement|positive regulation of DNA-binding transcription factor activity|regulation of cell cycle|embryonic retina morphogenesis in camera-type eye|lens induction in camera-type eye|SMAD protein signal transduction|iris morphogenesis|cellular response to hypoxia|RNA polymerase II transcription regulator complex|intrinsic apoptotic signaling pathway|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator|negative regulation of ubiquitin-dependent protein catabolic process" hsa04218 Cellular senescence HIPK3 780.9594513 744.93634 816.9825626 1.096714603 0.133188144 0.600435538 1 4.909952245 5.29470872 10114 homeodomain interacting protein kinase 3 "GO:0004672,GO:0004674,GO:0004713,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0006915,GO:0009299,GO:0016604,GO:0016605,GO:0018105,GO:0018107,GO:0018108,GO:0043066,GO:0043508,GO:0106310,GO:0106311" protein kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|protein phosphorylation|apoptotic process|mRNA transcription|nuclear body|PML body|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|negative regulation of apoptotic process|negative regulation of JUN kinase activity|protein serine kinase activity|protein threonine kinase activity hsa04218 Cellular senescence HIRA 836.9732243 878.109317 795.8371316 0.906307582 -0.141927341 0.572950265 1 11.56256609 10.3038854 7290 histone cell cycle regulator "GO:0000417,GO:0000785,GO:0001085,GO:0005515,GO:0005634,GO:0005654,GO:0006336,GO:0006351,GO:0006357,GO:0009653,GO:0016605,GO:0031491,GO:0032991,GO:0042393,GO:0045892,GO:0070062" "HIR complex|chromatin|RNA polymerase II transcription factor binding|protein binding|nucleus|nucleoplasm|DNA replication-independent nucleosome assembly|transcription, DNA-templated|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|PML body|nucleosome binding|protein-containing complex|histone binding|negative regulation of transcription, DNA-templated|extracellular exosome" other HIRIP3 464.1364896 451.5396251 476.7333542 1.055795168 0.078329968 0.784849716 1 9.380241298 9.737889876 8479 HIRA interacting protein 3 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006333" protein binding|nucleus|nucleoplasm|nucleolus|chromatin assembly or disassembly HIVEP1 1117.494328 1316.123562 918.8650939 0.698160204 -0.518369972 0.033318464 0.926077215 5.601650494 3.845406681 3096 HIVEP zinc finger 1 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006357,GO:0016604,GO:0030509,GO:0045944,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|regulation of transcription by RNA polymerase II|nuclear body|BMP signaling pathway|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 HIVEP2 2145.210507 2508.437871 1781.983142 0.710395566 -0.493305517 0.037096658 0.976206556 12.22675302 8.54048552 3097 HIVEP zinc finger 2 "GO:0000978,GO:0000981,GO:0003677,GO:0005634,GO:0005654,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding" HIVEP3 27.14007971 31.21241648 23.06774294 0.739056617 -0.436243205 0.587611108 1 0.079287415 0.057617332 59269 HIVEP zinc finger 3 "GO:0000978,GO:0000981,GO:0005634,GO:0005737,GO:0006357,GO:0035914,GO:0045893,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|skeletal muscle cell differentiation|positive regulation of transcription, DNA-templated|metal ion binding" HJURP 3004.773353 2982.866602 3026.680105 1.014688389 0.021036743 0.930645311 1 50.42448788 50.30896299 55355 Holliday junction recognition protein "GO:0000775,GO:0000777,GO:0003677,GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0007049,GO:0007059,GO:0034080,GO:0042393,GO:0042802,GO:0043254,GO:0051101" "chromosome, centromeric region|condensed chromosome kinetochore|DNA binding|protein binding|nucleoplasm|nucleolus|mitochondrion|cell cycle|chromosome segregation|CENP-A containing nucleosome assembly|histone binding|identical protein binding|regulation of protein-containing complex assembly|regulation of DNA binding" HK1 9790.822175 9425.109363 10156.53499 1.07760394 0.107827031 0.667420385 1 95.04927515 100.7115218 3098 hexokinase 1 "GO:0001678,GO:0002720,GO:0004340,GO:0004396,GO:0005515,GO:0005524,GO:0005536,GO:0005739,GO:0005741,GO:0005829,GO:0006002,GO:0006013,GO:0006096,GO:0006954,GO:0008865,GO:0019158,GO:0032731,GO:0042802,GO:0042834,GO:0045087,GO:0045121,GO:0046835,GO:0051156,GO:0061621,GO:0072655,GO:0072656" cellular glucose homeostasis|positive regulation of cytokine production involved in immune response|glucokinase activity|hexokinase activity|protein binding|ATP binding|glucose binding|mitochondrion|mitochondrial outer membrane|cytosol|fructose 6-phosphate metabolic process|mannose metabolic process|glycolytic process|inflammatory response|fructokinase activity|mannokinase activity|positive regulation of interleukin-1 beta production|identical protein binding|peptidoglycan binding|innate immune response|membrane raft|carbohydrate phosphorylation|glucose 6-phosphate metabolic process|canonical glycolysis|establishment of protein localization to mitochondrion|maintenance of protein location in mitochondrion "hsa00010,hsa00051,hsa00052,hsa00500,hsa00520,hsa00524,hsa04066,hsa04910,hsa04930,hsa04973,hsa05131,hsa05230" "Glycolysis / Gluconeogenesis|Fructose and mannose metabolism|Galactose metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism|Neomycin, kanamycin and gentamicin biosynthesis|HIF-1 signaling pathway|Insulin signaling pathway|Type II diabetes mellitus|Carbohydrate digestion and absorption|Shigellosis|Central carbon metabolism in cancer" HK2 582.5014824 594.076327 570.9266379 0.961032467 -0.057342924 0.834263842 1 5.470110715 5.168985987 3099 hexokinase 2 "GO:0001666,GO:0001678,GO:0002931,GO:0004340,GO:0004396,GO:0005515,GO:0005524,GO:0005536,GO:0005739,GO:0005741,GO:0005813,GO:0005829,GO:0005886,GO:0006002,GO:0006096,GO:0007595,GO:0008637,GO:0008865,GO:0016020,GO:0016529,GO:0019158,GO:0035795,GO:0043231,GO:0045766,GO:0046324,GO:0046835,GO:0051156,GO:0061621,GO:0072655,GO:0072656,GO:1904925,GO:1990830,GO:2000378" response to hypoxia|cellular glucose homeostasis|response to ischemia|glucokinase activity|hexokinase activity|protein binding|ATP binding|glucose binding|mitochondrion|mitochondrial outer membrane|centrosome|cytosol|plasma membrane|fructose 6-phosphate metabolic process|glycolytic process|lactation|apoptotic mitochondrial changes|fructokinase activity|membrane|sarcoplasmic reticulum|mannokinase activity|negative regulation of mitochondrial membrane permeability|intracellular membrane-bounded organelle|positive regulation of angiogenesis|regulation of glucose import|carbohydrate phosphorylation|glucose 6-phosphate metabolic process|canonical glycolysis|establishment of protein localization to mitochondrion|maintenance of protein location in mitochondrion|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization|cellular response to leukemia inhibitory factor|negative regulation of reactive oxygen species metabolic process "hsa00010,hsa00051,hsa00052,hsa00500,hsa00520,hsa00524,hsa04066,hsa04910,hsa04930,hsa04973,hsa05131,hsa05230" "Glycolysis / Gluconeogenesis|Fructose and mannose metabolism|Galactose metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism|Neomycin, kanamycin and gentamicin biosynthesis|HIF-1 signaling pathway|Insulin signaling pathway|Type II diabetes mellitus|Carbohydrate digestion and absorption|Shigellosis|Central carbon metabolism in cancer" HKDC1 117.8793844 155.0216685 80.7371003 0.52081171 -0.941166208 0.033290541 0.926077215 1.943439401 0.995228771 80201 hexokinase domain containing 1 "GO:0001678,GO:0004340,GO:0005524,GO:0005536,GO:0005739,GO:0005829,GO:0006096,GO:0008865,GO:0019158,GO:0019318,GO:0031966,GO:0046835,GO:0051156" cellular glucose homeostasis|glucokinase activity|ATP binding|glucose binding|mitochondrion|cytosol|glycolytic process|fructokinase activity|mannokinase activity|hexose metabolic process|mitochondrial membrane|carbohydrate phosphorylation|glucose 6-phosphate metabolic process "hsa00010,hsa00051,hsa00052,hsa00500,hsa00520,hsa00524,hsa04066,hsa04910,hsa04930,hsa04973,hsa05131,hsa05230" "Glycolysis / Gluconeogenesis|Fructose and mannose metabolism|Galactose metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism|Neomycin, kanamycin and gentamicin biosynthesis|HIF-1 signaling pathway|Insulin signaling pathway|Type II diabetes mellitus|Carbohydrate digestion and absorption|Shigellosis|Central carbon metabolism in cancer" HLA-A 3513.291594 3413.597949 3612.985239 1.058409717 0.081898212 0.730846032 1 118.6823769 123.5125911 3105 "major histocompatibility complex, class I, A" "GO:0000139,GO:0001913,GO:0001916,GO:0002419,GO:0002474,GO:0002479,GO:0002480,GO:0002485,GO:0002486,GO:0002726,GO:0003723,GO:0005102,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0005797,GO:0005886,GO:0005887,GO:0006955,GO:0009986,GO:0012507,GO:0016020,GO:0016032,GO:0016045,GO:0016567,GO:0019731,GO:0019885,GO:0030670,GO:0030881,GO:0031901,GO:0032729,GO:0036037,GO:0042270,GO:0042590,GO:0042605,GO:0042608,GO:0042610,GO:0042612,GO:0042824,GO:0046977,GO:0050776,GO:0050830,GO:0050852,GO:0055038,GO:0060333,GO:0060337,GO:0062061,GO:0070062,GO:0070971,GO:0071556,GO:2000566,GO:2000568,GO:2001187" "Golgi membrane|T cell mediated cytotoxicity|positive regulation of T cell mediated cytotoxicity|T cell mediated cytotoxicity directed against tumor cell target|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|positive regulation of T cell cytokine production|RNA binding|signaling receptor binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|Golgi medial cisterna|plasma membrane|integral component of plasma membrane|immune response|cell surface|ER to Golgi transport vesicle membrane|membrane|viral process|detection of bacterium|protein ubiquitination|antibacterial humoral response|antigen processing and presentation of endogenous peptide antigen via MHC class I|phagocytic vesicle membrane|beta-2-microglobulin binding|early endosome membrane|positive regulation of interferon-gamma production|CD8-positive, alpha-beta T cell activation|protection from natural killer cell mediated cytotoxicity|antigen processing and presentation of exogenous peptide antigen via MHC class I|peptide antigen binding|T cell receptor binding|CD8 receptor binding|MHC class I protein complex|MHC class I peptide loading complex|TAP binding|regulation of immune response|defense response to Gram-positive bacterium|T cell receptor signaling pathway|recycling endosome membrane|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|TAP complex binding|extracellular exosome|endoplasmic reticulum exit site|integral component of lumenal side of endoplasmic reticulum membrane|positive regulation of CD8-positive, alpha-beta T cell proliferation|positive regulation of memory T cell activation|positive regulation of CD8-positive, alpha-beta T cell activation" "hsa04144,hsa04145,hsa04218,hsa04514,hsa04612,hsa04650,hsa04940,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05203,hsa05320,hsa05330,hsa05332,hsa05416" Endocytosis|Phagosome|Cellular senescence|Cell adhesion molecules|Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Type I diabetes mellitus|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-B 363.1515619 311.0837509 415.219373 1.334751082 0.416570718 0.161175422 1 10.80857294 14.18534223 3106 "major histocompatibility complex, class I, B" "GO:0000139,GO:0001916,GO:0002250,GO:0002474,GO:0002479,GO:0002480,GO:0002486,GO:0002667,GO:0005102,GO:0005515,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0006952,GO:0006955,GO:0009986,GO:0012507,GO:0016020,GO:0016032,GO:0016045,GO:0030667,GO:0030670,GO:0031901,GO:0032655,GO:0032675,GO:0042270,GO:0042605,GO:0042612,GO:0043312,GO:0046977,GO:0050776,GO:0051087,GO:0055038,GO:0060333,GO:0060337,GO:0070062,GO:0071556,GO:2001198" "Golgi membrane|positive regulation of T cell mediated cytotoxicity|adaptive immune response|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|regulation of T cell anergy|signaling receptor binding|protein binding|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|defense response|immune response|cell surface|ER to Golgi transport vesicle membrane|membrane|viral process|detection of bacterium|secretory granule membrane|phagocytic vesicle membrane|early endosome membrane|regulation of interleukin-12 production|regulation of interleukin-6 production|protection from natural killer cell mediated cytotoxicity|peptide antigen binding|MHC class I protein complex|neutrophil degranulation|TAP binding|regulation of immune response|chaperone binding|recycling endosome membrane|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|extracellular exosome|integral component of lumenal side of endoplasmic reticulum membrane|regulation of dendritic cell differentiation" "hsa04144,hsa04145,hsa04218,hsa04514,hsa04612,hsa04650,hsa04940,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05203,hsa05320,hsa05330,hsa05332,hsa05416" Endocytosis|Phagosome|Cellular senescence|Cell adhesion molecules|Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Type I diabetes mellitus|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-C 800.5442615 741.8150983 859.2734247 1.158339088 0.212057645 0.400548526 1 25.67400026 29.24155285 3107 "major histocompatibility complex, class I, C" "GO:0000139,GO:0002250,GO:0002474,GO:0002479,GO:0002480,GO:0002486,GO:0005515,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0006955,GO:0009986,GO:0012507,GO:0016020,GO:0016032,GO:0030667,GO:0030670,GO:0031901,GO:0042605,GO:0042612,GO:0043312,GO:0046977,GO:0050776,GO:0055038,GO:0060333,GO:0060337,GO:0070062,GO:0071556" "Golgi membrane|adaptive immune response|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|protein binding|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|immune response|cell surface|ER to Golgi transport vesicle membrane|membrane|viral process|secretory granule membrane|phagocytic vesicle membrane|early endosome membrane|peptide antigen binding|MHC class I protein complex|neutrophil degranulation|TAP binding|regulation of immune response|recycling endosome membrane|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|extracellular exosome|integral component of lumenal side of endoplasmic reticulum membrane" "hsa04144,hsa04145,hsa04218,hsa04514,hsa04612,hsa04650,hsa04940,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05203,hsa05320,hsa05330,hsa05332,hsa05416" Endocytosis|Phagosome|Cellular senescence|Cell adhesion molecules|Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Type I diabetes mellitus|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-DMA 52.32324897 48.89945248 55.74704545 1.140034144 0.189077034 0.775113022 1 2.387624799 2.676425249 3108 "major histocompatibility complex, class II, DM alpha" "GO:0002250,GO:0002503,GO:0005515,GO:0005765,GO:0009986,GO:0016020,GO:0016021,GO:0019886,GO:0023026,GO:0031902,GO:0042613,GO:0043231" adaptive immune response|peptide antigen assembly with MHC class II protein complex|protein binding|lysosomal membrane|cell surface|membrane|integral component of membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|MHC class II protein complex binding|late endosome membrane|MHC class II protein complex|intracellular membrane-bounded organelle "hsa04145,hsa04514,hsa04612,hsa04640,hsa04658,hsa04659,hsa04672,hsa04940,hsa05140,hsa05145,hsa05150,hsa05152,hsa05164,hsa05166,hsa05168,hsa05169,hsa05310,hsa05320,hsa05321,hsa05322,hsa05323,hsa05330,hsa05332,hsa05416" Phagosome|Cell adhesion molecules|Antigen processing and presentation|Hematopoietic cell lineage|Th1 and Th2 cell differentiation|Th17 cell differentiation|Intestinal immune network for IgA production|Type I diabetes mellitus|Leishmaniasis|Toxoplasmosis|Staphylococcus aureus infection|Tuberculosis|Influenza A|Human T-cell leukemia virus 1 infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Asthma|Autoimmune thyroid disease|Inflammatory bowel disease|Systemic lupus erythematosus|Rheumatoid arthritis|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-DPA1 93.55860589 84.27352449 102.8436873 1.220355834 0.287301874 0.559589435 1 2.570013208 3.083848367 3113 "major histocompatibility complex, class II, DP alpha 1" "GO:0000139,GO:0002250,GO:0005765,GO:0005886,GO:0005887,GO:0006955,GO:0009986,GO:0010008,GO:0012507,GO:0019886,GO:0030658,GO:0030666,GO:0030669,GO:0032395,GO:0032588,GO:0032729,GO:0042102,GO:0042605,GO:0042613,GO:0043231,GO:0050852,GO:0050870,GO:0060333,GO:0071346,GO:0071556" Golgi membrane|adaptive immune response|lysosomal membrane|plasma membrane|integral component of plasma membrane|immune response|cell surface|endosome membrane|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|transport vesicle membrane|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|MHC class II receptor activity|trans-Golgi network membrane|positive regulation of interferon-gamma production|positive regulation of T cell proliferation|peptide antigen binding|MHC class II protein complex|intracellular membrane-bounded organelle|T cell receptor signaling pathway|positive regulation of T cell activation|interferon-gamma-mediated signaling pathway|cellular response to interferon-gamma|integral component of lumenal side of endoplasmic reticulum membrane "hsa04145,hsa04514,hsa04612,hsa04640,hsa04658,hsa04659,hsa04672,hsa04940,hsa05140,hsa05145,hsa05150,hsa05152,hsa05164,hsa05166,hsa05168,hsa05169,hsa05310,hsa05320,hsa05321,hsa05322,hsa05323,hsa05330,hsa05332,hsa05416" Phagosome|Cell adhesion molecules|Antigen processing and presentation|Hematopoietic cell lineage|Th1 and Th2 cell differentiation|Th17 cell differentiation|Intestinal immune network for IgA production|Type I diabetes mellitus|Leishmaniasis|Toxoplasmosis|Staphylococcus aureus infection|Tuberculosis|Influenza A|Human T-cell leukemia virus 1 infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Asthma|Autoimmune thyroid disease|Inflammatory bowel disease|Systemic lupus erythematosus|Rheumatoid arthritis|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-DPB1 492.5006512 426.5696919 558.4316104 1.30912163 0.388599144 0.156679703 1 5.704144438 7.342461724 3115 "major histocompatibility complex, class II, DP beta 1" "GO:0000139,GO:0002250,GO:0005515,GO:0005765,GO:0005886,GO:0009986,GO:0010008,GO:0012507,GO:0016020,GO:0019886,GO:0030658,GO:0030666,GO:0030669,GO:0032588,GO:0032729,GO:0042102,GO:0042605,GO:0042613,GO:0050852,GO:0050870,GO:0060333,GO:0071556" Golgi membrane|adaptive immune response|protein binding|lysosomal membrane|plasma membrane|cell surface|endosome membrane|ER to Golgi transport vesicle membrane|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|transport vesicle membrane|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|trans-Golgi network membrane|positive regulation of interferon-gamma production|positive regulation of T cell proliferation|peptide antigen binding|MHC class II protein complex|T cell receptor signaling pathway|positive regulation of T cell activation|interferon-gamma-mediated signaling pathway|integral component of lumenal side of endoplasmic reticulum membrane "hsa04145,hsa04514,hsa04612,hsa04640,hsa04658,hsa04659,hsa04672,hsa04940,hsa05140,hsa05145,hsa05150,hsa05152,hsa05164,hsa05166,hsa05168,hsa05169,hsa05310,hsa05320,hsa05321,hsa05322,hsa05323,hsa05330,hsa05332,hsa05416" Phagosome|Cell adhesion molecules|Antigen processing and presentation|Hematopoietic cell lineage|Th1 and Th2 cell differentiation|Th17 cell differentiation|Intestinal immune network for IgA production|Type I diabetes mellitus|Leishmaniasis|Toxoplasmosis|Staphylococcus aureus infection|Tuberculosis|Influenza A|Human T-cell leukemia virus 1 infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Asthma|Autoimmune thyroid disease|Inflammatory bowel disease|Systemic lupus erythematosus|Rheumatoid arthritis|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-E 6381.355047 6857.3679 5905.342194 0.861167474 -0.215634264 0.374951384 1 136.6051219 115.6713436 3133 "major histocompatibility complex, class I, E" "GO:0000139,GO:0001815,GO:0001916,GO:0002250,GO:0002474,GO:0002476,GO:0002477,GO:0002479,GO:0002480,GO:0002486,GO:0002519,GO:0002639,GO:0002715,GO:0002717,GO:0002729,GO:0005102,GO:0005515,GO:0005615,GO:0005886,GO:0006955,GO:0009897,GO:0009986,GO:0012507,GO:0016032,GO:0019731,GO:0030670,GO:0030881,GO:0031901,GO:0032398,GO:0032736,GO:0032753,GO:0032759,GO:0032760,GO:0032819,GO:0036037,GO:0042270,GO:0042288,GO:0042605,GO:0042608,GO:0042612,GO:0045087,GO:0045953,GO:0045954,GO:0046703,GO:0050776,GO:0050830,GO:0055038,GO:0060333,GO:0060337,GO:0070062,GO:0071556,GO:2000566,GO:2001187" "Golgi membrane|positive regulation of antibody-dependent cellular cytotoxicity|positive regulation of T cell mediated cytotoxicity|adaptive immune response|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of endogenous peptide antigen via MHC class Ib|antigen processing and presentation of exogenous peptide antigen via MHC class Ib|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|natural killer cell tolerance induction|positive regulation of immunoglobulin production|regulation of natural killer cell mediated immunity|positive regulation of natural killer cell mediated immunity|positive regulation of natural killer cell cytokine production|signaling receptor binding|protein binding|extracellular space|plasma membrane|immune response|external side of plasma membrane|cell surface|ER to Golgi transport vesicle membrane|viral process|antibacterial humoral response|phagocytic vesicle membrane|beta-2-microglobulin binding|early endosome membrane|MHC class Ib protein complex|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of TRAIL production|positive regulation of tumor necrosis factor production|positive regulation of natural killer cell proliferation|CD8-positive, alpha-beta T cell activation|protection from natural killer cell mediated cytotoxicity|MHC class I protein binding|peptide antigen binding|T cell receptor binding|MHC class I protein complex|innate immune response|negative regulation of natural killer cell mediated cytotoxicity|positive regulation of natural killer cell mediated cytotoxicity|natural killer cell lectin-like receptor binding|regulation of immune response|defense response to Gram-positive bacterium|recycling endosome membrane|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|extracellular exosome|integral component of lumenal side of endoplasmic reticulum membrane|positive regulation of CD8-positive, alpha-beta T cell proliferation|positive regulation of CD8-positive, alpha-beta T cell activation" "hsa04144,hsa04145,hsa04218,hsa04514,hsa04612,hsa04650,hsa04940,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05203,hsa05320,hsa05330,hsa05332,hsa05416" Endocytosis|Phagosome|Cellular senescence|Cell adhesion molecules|Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Type I diabetes mellitus|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-F 146.1938561 153.9812546 138.4064577 0.898852643 -0.153843474 0.719333676 1 1.423224204 1.257862006 3134 "major histocompatibility complex, class I, F" "GO:0000139,GO:0001916,GO:0002474,GO:0002476,GO:0002477,GO:0002479,GO:0002480,GO:0002486,GO:0002725,GO:0002728,GO:0002729,GO:0005102,GO:0005515,GO:0005615,GO:0005765,GO:0005783,GO:0005886,GO:0006955,GO:0009897,GO:0009986,GO:0012507,GO:0016020,GO:0030670,GO:0030881,GO:0031901,GO:0032398,GO:0042605,GO:0042612,GO:0043322,GO:0043323,GO:0045953,GO:0046978,GO:0046979,GO:0050776,GO:0055038,GO:0060333,GO:0060337,GO:0071556,GO:0071889,GO:1901215" "Golgi membrane|positive regulation of T cell mediated cytotoxicity|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of endogenous peptide antigen via MHC class Ib|antigen processing and presentation of exogenous peptide antigen via MHC class Ib|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|negative regulation of T cell cytokine production|negative regulation of natural killer cell cytokine production|positive regulation of natural killer cell cytokine production|signaling receptor binding|protein binding|extracellular space|lysosomal membrane|endoplasmic reticulum|plasma membrane|immune response|external side of plasma membrane|cell surface|ER to Golgi transport vesicle membrane|membrane|phagocytic vesicle membrane|beta-2-microglobulin binding|early endosome membrane|MHC class Ib protein complex|peptide antigen binding|MHC class I protein complex|negative regulation of natural killer cell degranulation|positive regulation of natural killer cell degranulation|negative regulation of natural killer cell mediated cytotoxicity|TAP1 binding|TAP2 binding|regulation of immune response|recycling endosome membrane|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|integral component of lumenal side of endoplasmic reticulum membrane|14-3-3 protein binding|negative regulation of neuron death" "hsa04144,hsa04145,hsa04218,hsa04514,hsa04612,hsa04650,hsa04940,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05203,hsa05320,hsa05330,hsa05332,hsa05416" Endocytosis|Phagosome|Cellular senescence|Cell adhesion molecules|Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Type I diabetes mellitus|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLCS 542.0442279 516.0452858 568.04317 1.10076225 0.1385029 0.609773339 1 2.244347523 2.429152674 3141 holocarboxylase synthetase "GO:0000785,GO:0004077,GO:0004078,GO:0004079,GO:0004080,GO:0005515,GO:0005524,GO:0005652,GO:0005737,GO:0005739,GO:0005829,GO:0006768,GO:0009305,GO:0009374,GO:0016363,GO:0016570,GO:0018215,GO:0018271,GO:0019899,GO:0070781,GO:0071110" chromatin|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|protein binding|ATP binding|nuclear lamina|cytoplasm|mitochondrion|cytosol|biotin metabolic process|protein biotinylation|biotin binding|nuclear matrix|histone modification|protein phosphopantetheinylation|biotin-protein ligase activity|enzyme binding|response to biotin|histone biotinylation hsa00780 Biotin metabolism HLF 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.028630961 0.008669091 3131 "HLF transcription factor, PAR bZIP family member" "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003690,GO:0005634,GO:0005654,GO:0006357,GO:0007275,GO:0035914,GO:0043565,GO:0045944,GO:0048511,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|double-stranded DNA binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|multicellular organism development|skeletal muscle cell differentiation|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|rhythmic process|sequence-specific double-stranded DNA binding" HLTF 2550.679926 2454.336349 2647.023503 1.078508862 0.109038031 0.645496278 1 24.32827267 25.79919597 6596 helicase like transcription factor "GO:0003677,GO:0003723,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006325,GO:0008094,GO:0008270,GO:0016020,GO:0016567,GO:0031625,GO:0045944,GO:0061630" DNA binding|RNA binding|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|chromatin organization|DNA-dependent ATPase activity|zinc ion binding|membrane|protein ubiquitination|ubiquitin protein ligase binding|positive regulation of transcription by RNA polymerase II|ubiquitin protein ligase activity HLX 106.598378 123.809252 89.38750391 0.721977578 -0.469974062 0.30682257 1 2.953720263 2.096834971 3142 H2.0 like homeobox "GO:0000785,GO:0000981,GO:0001889,GO:0005515,GO:0005634,GO:0006357,GO:0007275,GO:0007519,GO:0008284,GO:0030154,GO:0043565,GO:0045627,GO:0045629,GO:0046622,GO:0048484,GO:0048557" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|liver development|protein binding|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|skeletal muscle tissue development|positive regulation of cell population proliferation|cell differentiation|sequence-specific DNA binding|positive regulation of T-helper 1 cell differentiation|negative regulation of T-helper 2 cell differentiation|positive regulation of organ growth|enteric nervous system development|embryonic digestive tract morphogenesis" HM13 3950.966726 3839.127227 4062.806226 1.058262982 0.081698186 0.732131666 1 39.50012803 41.10203138 81502 histocompatibility minor 13 "GO:0001701,GO:0005515,GO:0005783,GO:0005789,GO:0005791,GO:0005886,GO:0006465,GO:0006509,GO:0008233,GO:0009986,GO:0016020,GO:0031293,GO:0031625,GO:0033619,GO:0036513,GO:0042500,GO:0042803,GO:0071458,GO:0071556,GO:1904211" "in utero embryonic development|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|rough endoplasmic reticulum|plasma membrane|signal peptide processing|membrane protein ectodomain proteolysis|peptidase activity|cell surface|membrane|membrane protein intracellular domain proteolysis|ubiquitin protein ligase binding|membrane protein proteolysis|Derlin-1 retrotranslocation complex|aspartic endopeptidase activity, intramembrane cleaving|protein homodimerization activity|integral component of cytoplasmic side of endoplasmic reticulum membrane|integral component of lumenal side of endoplasmic reticulum membrane|membrane protein proteolysis involved in retrograde protein transport, ER to cytosol" HMBOX1 773.9288048 800.0782758 747.7793338 0.934632718 -0.097528553 0.703049506 1 2.419327276 2.223344603 79618 homeobox containing 1 "GO:0000122,GO:0000781,GO:0000785,GO:0003691,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0015030,GO:0016604,GO:0016605,GO:0032212,GO:0035563,GO:0042162,GO:0042802,GO:0043565,GO:0044877,GO:0045892,GO:0045893,GO:0051972,GO:0051973,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromosome, telomeric region|chromatin|double-stranded telomeric DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|Cajal body|nuclear body|PML body|positive regulation of telomere maintenance via telomerase|positive regulation of chromatin binding|telomeric DNA binding|identical protein binding|sequence-specific DNA binding|protein-containing complex binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|regulation of telomerase activity|positive regulation of telomerase activity|sequence-specific double-stranded DNA binding" HMBS 696.1204461 687.7135764 704.5273157 1.024448753 0.034847817 0.897568556 1 16.1754119 16.29358931 3145 hydroxymethylbilane synthase "GO:0004418,GO:0005515,GO:0005737,GO:0005829,GO:0006782,GO:0006783,GO:0018160" hydroxymethylbilane synthase activity|protein binding|cytoplasm|cytosol|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|peptidyl-pyrromethane cofactor linkage hsa00860 Porphyrin and chlorophyll metabolism HMCES 916.9617903 946.7766332 887.1469474 0.937018211 -0.093851007 0.708004282 1 18.3005175 16.86097098 56941 "5-hydroxymethylcytosine binding, ES cell specific" "GO:0003697,GO:0003906,GO:0005515,GO:0005657,GO:0006508,GO:0006974,GO:0008233,GO:0018142,GO:0045830,GO:0097681" single-stranded DNA binding|DNA-(apurinic or apyrimidinic site) endonuclease activity|protein binding|replication fork|proteolysis|cellular response to DNA damage stimulus|peptidase activity|protein-DNA covalent cross-linking|positive regulation of isotype switching|double-strand break repair via alternative nonhomologous end joining HMCN1 43.55395847 45.77821084 41.32970611 0.902824845 -0.147481974 0.848695291 1 0.132957767 0.118028909 83872 hemicentin 1 "GO:0005201,GO:0005509,GO:0005515,GO:0005604,GO:0005912,GO:0005938,GO:0007049,GO:0007156,GO:0007157,GO:0007601,GO:0009617,GO:0032154,GO:0051301,GO:0062023,GO:0070062" extracellular matrix structural constituent|calcium ion binding|protein binding|basement membrane|adherens junction|cell cortex|cell cycle|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|visual perception|response to bacterium|cleavage furrow|cell division|collagen-containing extracellular matrix|extracellular exosome HMG20A 1248.931118 1120.525752 1377.336485 1.229187712 0.29770525 0.21757955 1 13.85551435 16.74603679 10363 high mobility group 20A "GO:0000122,GO:0003677,GO:0005515,GO:0005634,GO:0006325,GO:0006355,GO:0010468,GO:0033234,GO:0042802,GO:0045665" "negative regulation of transcription by RNA polymerase II|DNA binding|protein binding|nucleus|chromatin organization|regulation of transcription, DNA-templated|regulation of gene expression|negative regulation of protein sumoylation|identical protein binding|negative regulation of neuron differentiation" HMG HMG20B 2009.557225 1937.250649 2081.863801 1.074648653 0.10386506 0.661885838 1 49.39680203 52.19591445 10362 high mobility group 20B "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006325,GO:0007049,GO:0007596,GO:0010468,GO:0016604,GO:0033234,GO:0035914,GO:0045666" DNA binding|protein binding|nucleus|nucleoplasm|chromosome|chromatin organization|cell cycle|blood coagulation|regulation of gene expression|nuclear body|negative regulation of protein sumoylation|skeletal muscle cell differentiation|positive regulation of neuron differentiation HMGA1 45469.53223 45803.18077 45135.88369 0.985431207 -0.021172935 0.947163194 1 1191.243458 1154.245044 3159 high mobility group AT-hook 1 "GO:0000987,GO:0003677,GO:0003680,GO:0003682,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0005925,GO:0006268,GO:0006337,GO:0006355,GO:0008134,GO:0008285,GO:0009615,GO:0019899,GO:0030374,GO:0030527,GO:0031936,GO:0035985,GO:0035986,GO:0042974,GO:0042975,GO:0045892,GO:0045893,GO:0045944,GO:0046965,GO:0051169,GO:0075713,GO:0090402,GO:0090575,GO:2000774" "cis-regulatory region sequence-specific DNA binding|DNA binding|minor groove of adenine-thymine-rich DNA binding|chromatin binding|transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|focal adhesion|DNA unwinding involved in DNA replication|nucleosome disassembly|regulation of transcription, DNA-templated|transcription factor binding|negative regulation of cell population proliferation|response to virus|enzyme binding|nuclear receptor coactivator activity|structural constituent of chromatin|negative regulation of chromatin silencing|senescence-associated heterochromatin focus|senescence-associated heterochromatin focus assembly|retinoic acid receptor binding|peroxisome proliferator activated receptor binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|retinoid X receptor binding|nuclear transport|establishment of integrated proviral latency|oncogene-induced cell senescence|RNA polymerase II transcription regulator complex|positive regulation of cellular senescence" HMGA2 3154.333828 3528.043476 2780.624181 0.788149069 -0.343459571 0.147184148 1 31.05991357 24.07020496 8091 high mobility group AT-hook 2 "GO:0000122,GO:0000228,GO:0000976,GO:0001837,GO:0002062,GO:0003131,GO:0003680,GO:0003712,GO:0003714,GO:0003906,GO:0005515,GO:0005634,GO:0005654,GO:0006284,GO:0006325,GO:0006355,GO:0007095,GO:0007275,GO:0008134,GO:0008301,GO:0009615,GO:0010564,GO:0010628,GO:0030261,GO:0031052,GO:0031492,GO:0031507,GO:0032993,GO:0035497,GO:0035500,GO:0035501,GO:0035978,GO:0035985,GO:0035986,GO:0035987,GO:0035988,GO:0040008,GO:0042769,GO:0043065,GO:0043066,GO:0043392,GO:0043922,GO:0045444,GO:0045766,GO:0045869,GO:0045892,GO:0045893,GO:0045944,GO:0046332,GO:0048333,GO:0048762,GO:0048863,GO:0051301,GO:0051575,GO:0070742,GO:0071141,GO:0071158,GO:0071864,GO:0071902,GO:0090402,GO:2000036,GO:2000648,GO:2000685,GO:2000773,GO:2000774,GO:2001022,GO:2001033,GO:2001038" "negative regulation of transcription by RNA polymerase II|nuclear chromosome|transcription regulatory region sequence-specific DNA binding|epithelial to mesenchymal transition|chondrocyte differentiation|mesodermal-endodermal cell signaling|minor groove of adenine-thymine-rich DNA binding|transcription coregulator activity|transcription corepressor activity|DNA-(apurinic or apyrimidinic site) endonuclease activity|protein binding|nucleus|nucleoplasm|base-excision repair|chromatin organization|regulation of transcription, DNA-templated|mitotic G2 DNA damage checkpoint|multicellular organism development|transcription factor binding|DNA binding, bending|response to virus|regulation of cell cycle process|positive regulation of gene expression|chromosome condensation|chromosome breakage|nucleosomal DNA binding|heterochromatin assembly|protein-DNA complex|cAMP response element binding|MH2 domain binding|MH1 domain binding|histone H2A-S139 phosphorylation|senescence-associated heterochromatin focus|senescence-associated heterochromatin focus assembly|endodermal cell differentiation|chondrocyte proliferation|regulation of growth|DNA damage response, detection of DNA damage|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of DNA binding|negative regulation by host of viral transcription|fat cell differentiation|positive regulation of angiogenesis|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|SMAD binding|mesodermal cell differentiation|mesenchymal cell differentiation|stem cell differentiation|cell division|5'-deoxyribose-5-phosphate lyase activity|C2H2 zinc finger domain binding|SMAD protein complex|positive regulation of cell cycle arrest|positive regulation of cell proliferation in bone marrow|positive regulation of protein serine/threonine kinase activity|oncogene-induced cell senescence|regulation of stem cell population maintenance|positive regulation of stem cell proliferation|positive regulation of cellular response to X-ray|negative regulation of cellular senescence|positive regulation of cellular senescence|positive regulation of response to DNA damage stimulus|negative regulation of double-strand break repair via nonhomologous end joining|regulation of cellular response to drug" "hsa05202,hsa05206" Transcriptional misregulation in cancer|MicroRNAs in cancer HMGB1 8001.196057 7521.151958 8481.240156 1.127651748 0.173321591 0.48240569 1 55.87278072 61.95073487 3146 high mobility group box 1 "GO:0000122,GO:0000400,GO:0000405,GO:0000793,GO:0000976,GO:0001530,GO:0001654,GO:0001773,GO:0001786,GO:0001935,GO:0002218,GO:0002224,GO:0002270,GO:0002281,GO:0002407,GO:0002437,GO:0002643,GO:0002840,GO:0003684,GO:0003690,GO:0003697,GO:0003713,GO:0003723,GO:0003725,GO:0003727,GO:0005125,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005769,GO:0005793,GO:0006265,GO:0006284,GO:0006303,GO:0006309,GO:0006310,GO:0006342,GO:0006357,GO:0006914,GO:0006954,GO:0007204,GO:0008134,GO:0008301,GO:0009986,GO:0010508,GO:0010858,GO:0016032,GO:0016829,GO:0017053,GO:0017055,GO:0019958,GO:0030295,GO:0030324,GO:0031175,GO:0031497,GO:0032072,GO:0032147,GO:0032392,GO:0032425,GO:0032640,GO:0032689,GO:0032727,GO:0032728,GO:0032731,GO:0032732,GO:0032733,GO:0032735,GO:0032755,GO:0032757,GO:0032760,GO:0033151,GO:0034137,GO:0034145,GO:0034165,GO:0034774,GO:0035711,GO:0035767,GO:0035868,GO:0042056,GO:0042104,GO:0043005,GO:0043065,GO:0043277,GO:0043280,GO:0043312,GO:0043371,GO:0043388,GO:0043410,GO:0043536,GO:0043537,GO:0045063,GO:0045087,GO:0045639,GO:0045819,GO:0045944,GO:0046330,GO:0050786,GO:0050918,GO:0051106,GO:0051384,GO:0070182,GO:0070374,GO:0070491,GO:0071222,GO:0071639,GO:0090026,GO:0090303,GO:0097100,GO:0097350,GO:0098761,GO:1901224,GO:1903672,GO:1904813,GO:1905564,GO:2000343,GO:2000426,GO:2000819,GO:2001200" "negative regulation of transcription by RNA polymerase II|four-way junction DNA binding|bubble DNA binding|condensed chromosome|transcription regulatory region sequence-specific DNA binding|lipopolysaccharide binding|eye development|myeloid dendritic cell activation|phosphatidylserine binding|endothelial cell proliferation|activation of innate immune response|toll-like receptor signaling pathway|plasmacytoid dendritic cell activation|macrophage activation involved in immune response|dendritic cell chemotaxis|inflammatory response to antigenic stimulus|regulation of tolerance induction|regulation of T cell mediated immune response to tumor cell|damaged DNA binding|double-stranded DNA binding|single-stranded DNA binding|transcription coactivator activity|RNA binding|double-stranded RNA binding|single-stranded RNA binding|cytokine activity|integrin binding|protein binding|extracellular region|extracellular space|nucleus|nucleoplasm|early endosome|endoplasmic reticulum-Golgi intermediate compartment|DNA topological change|base-excision repair|double-strand break repair via nonhomologous end joining|apoptotic DNA fragmentation|DNA recombination|chromatin silencing|regulation of transcription by RNA polymerase II|autophagy|inflammatory response|positive regulation of cytosolic calcium ion concentration|transcription factor binding|DNA binding, bending|cell surface|positive regulation of autophagy|calcium-dependent protein kinase regulator activity|viral process|lyase activity|transcription repressor complex|negative regulation of RNA polymerase II transcription preinitiation complex assembly|C-X-C chemokine binding|protein kinase activator activity|lung development|neuron projection development|chromatin assembly|regulation of restriction endodeoxyribonuclease activity|activation of protein kinase activity|DNA geometric change|positive regulation of mismatch repair|tumor necrosis factor production|negative regulation of interferon-gamma production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|V(D)J recombination|positive regulation of toll-like receptor 2 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of toll-like receptor 9 signaling pathway|secretory granule lumen|T-helper 1 cell activation|endothelial cell chemotaxis|alphav-beta3 integrin-HMGB1 complex|chemoattractant activity|positive regulation of activated T cell proliferation|neuron projection|positive regulation of apoptotic process|apoptotic cell clearance|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|neutrophil degranulation|negative regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of DNA binding|positive regulation of MAPK cascade|positive regulation of blood vessel endothelial cell migration|negative regulation of blood vessel endothelial cell migration|T-helper 1 cell differentiation|innate immune response|positive regulation of myeloid cell differentiation|positive regulation of glycogen catabolic process|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|RAGE receptor binding|positive chemotaxis|positive regulation of DNA ligation|response to glucocorticoid|DNA polymerase binding|positive regulation of ERK1 and ERK2 cascade|repressing transcription factor binding|cellular response to lipopolysaccharide|positive regulation of monocyte chemotactic protein-1 production|positive regulation of monocyte chemotaxis|positive regulation of wound healing|supercoiled DNA binding|neutrophil clearance|cellular response to interleukin-7|positive regulation of NIK/NF-kappaB signaling|positive regulation of sprouting angiogenesis|ficolin-1-rich granule lumen|positive regulation of vascular endothelial cell proliferation|positive regulation of chemokine (C-X-C motif) ligand 2 production|negative regulation of apoptotic cell clearance|regulation of nucleotide-excision repair|positive regulation of dendritic cell differentiation" "hsa03410,hsa04140,hsa04217" Base excision repair|Autophagy - animal|Necroptosis HMGB2 3849.04015 3749.651633 3948.428667 1.053012134 0.074522061 0.754821538 1 127.7039031 132.2235232 3148 high mobility group box 2 "GO:0000400,GO:0000785,GO:0000793,GO:0000976,GO:0000987,GO:0001938,GO:0002437,GO:0003677,GO:0003684,GO:0003690,GO:0003697,GO:0003713,GO:0003723,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006265,GO:0006303,GO:0006309,GO:0006325,GO:0006334,GO:0006357,GO:0007289,GO:0008134,GO:0008301,GO:0008584,GO:0019904,GO:0032075,GO:0032392,GO:0032496,GO:0032728,GO:0032991,GO:0033151,GO:0042056,GO:0043388,GO:0044378,GO:0045087,GO:0045089,GO:0045648,GO:0045654,GO:0045892,GO:0045893,GO:0045944,GO:0048471,GO:0048545,GO:0050767,GO:0050786,GO:0050829,GO:0050830,GO:0050918,GO:0060326,GO:0071222,GO:0072091,GO:0097100,GO:1902042" "four-way junction DNA binding|chromatin|condensed chromosome|transcription regulatory region sequence-specific DNA binding|cis-regulatory region sequence-specific DNA binding|positive regulation of endothelial cell proliferation|inflammatory response to antigenic stimulus|DNA binding|damaged DNA binding|double-stranded DNA binding|single-stranded DNA binding|transcription coactivator activity|RNA binding|protein binding|extracellular space|nucleus|nucleoplasm|nucleolus|cytoplasm|DNA topological change|double-strand break repair via nonhomologous end joining|apoptotic DNA fragmentation|chromatin organization|nucleosome assembly|regulation of transcription by RNA polymerase II|spermatid nucleus differentiation|transcription factor binding|DNA binding, bending|male gonad development|protein domain specific binding|positive regulation of nuclease activity|DNA geometric change|response to lipopolysaccharide|positive regulation of interferon-beta production|protein-containing complex|V(D)J recombination|chemoattractant activity|positive regulation of DNA binding|non-sequence-specific DNA binding, bending|innate immune response|positive regulation of innate immune response|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|response to steroid hormone|regulation of neurogenesis|RAGE receptor binding|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|positive chemotaxis|cell chemotaxis|cellular response to lipopolysaccharide|regulation of stem cell proliferation|supercoiled DNA binding|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors" HMGB3 1254.281028 1260.981626 1247.580431 0.989372411 -0.015414425 0.952635442 1 17.22894823 16.76060689 3149 high mobility group box 3 "GO:0000400,GO:0003690,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0006310,GO:0006357,GO:0007275,GO:0008301,GO:0032392,GO:0045087,GO:0045578,GO:0045638" "four-way junction DNA binding|double-stranded DNA binding|RNA binding|protein binding|nucleus|cytoplasm|DNA recombination|regulation of transcription by RNA polymerase II|multicellular organism development|DNA binding, bending|DNA geometric change|innate immune response|negative regulation of B cell differentiation|negative regulation of myeloid cell differentiation" HMGCL 658.0459598 659.6224016 656.4695179 0.995220169 -0.006912372 0.985330868 1 22.42218805 21.94160224 3155 3-hydroxy-3-methylglutaryl-CoA lyase "GO:0000062,GO:0000287,GO:0001889,GO:0004419,GO:0005198,GO:0005739,GO:0005759,GO:0005777,GO:0005782,GO:0005829,GO:0006552,GO:0006625,GO:0006629,GO:0006637,GO:0007005,GO:0007584,GO:0030145,GO:0031406,GO:0032991,GO:0042594,GO:0046872,GO:0046951,GO:0070542" fatty-acyl-CoA binding|magnesium ion binding|liver development|hydroxymethylglutaryl-CoA lyase activity|structural molecule activity|mitochondrion|mitochondrial matrix|peroxisome|peroxisomal matrix|cytosol|leucine catabolic process|protein targeting to peroxisome|lipid metabolic process|acyl-CoA metabolic process|mitochondrion organization|response to nutrient|manganese ion binding|carboxylic acid binding|protein-containing complex|response to starvation|metal ion binding|ketone body biosynthetic process|response to fatty acid "hsa00072,hsa00280,hsa00650,hsa04146" "Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Butanoate metabolism|Peroxisome" HMGCR 1041.227697 1054.979677 1027.475717 0.973929393 -0.038110909 0.880166566 1 11.19775783 10.72333128 3156 3-hydroxy-3-methylglutaryl-CoA reductase "GO:0004420,GO:0005515,GO:0005778,GO:0005783,GO:0005789,GO:0006695,GO:0008299,GO:0015936,GO:0016021,GO:0016126,GO:0019216,GO:0042177,GO:0042282,GO:0045540,GO:0050709,GO:0055114,GO:0070402,GO:0120225,GO:1900222" hydroxymethylglutaryl-CoA reductase (NADPH) activity|protein binding|peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol biosynthetic process|isoprenoid biosynthetic process|coenzyme A metabolic process|integral component of membrane|sterol biosynthetic process|regulation of lipid metabolic process|negative regulation of protein catabolic process|hydroxymethylglutaryl-CoA reductase activity|regulation of cholesterol biosynthetic process|negative regulation of protein secretion|oxidation-reduction process|NADPH binding|coenzyme A binding|negative regulation of amyloid-beta clearance "hsa00900,hsa04152,hsa04976" Terpenoid backbone biosynthesis|AMPK signaling pathway|Bile secretion HMGCS1 787.1270927 843.7756588 730.4785266 0.865726001 -0.208017606 0.410513811 1 6.994525647 5.954014755 3157 3-hydroxy-3-methylglutaryl-CoA synthase 1 "GO:0001889,GO:0004421,GO:0005737,GO:0005829,GO:0006084,GO:0006629,GO:0006695,GO:0007420,GO:0008144,GO:0008584,GO:0009645,GO:0010142,GO:0014074,GO:0016853,GO:0019216,GO:0033197,GO:0042493,GO:0042803,GO:0043177,GO:0045540,GO:0046690,GO:0071372,GO:0071397,GO:0071404" "liver development|hydroxymethylglutaryl-CoA synthase activity|cytoplasm|cytosol|acetyl-CoA metabolic process|lipid metabolic process|cholesterol biosynthetic process|brain development|drug binding|male gonad development|response to low light intensity stimulus|farnesyl diphosphate biosynthetic process, mevalonate pathway|response to purine-containing compound|isomerase activity|regulation of lipid metabolic process|response to vitamin E|response to drug|protein homodimerization activity|organic acid binding|regulation of cholesterol biosynthetic process|response to tellurium ion|cellular response to follicle-stimulating hormone stimulus|cellular response to cholesterol|cellular response to low-density lipoprotein particle stimulus" "hsa00072,hsa00280,hsa00650,hsa00900,hsa03320" "Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Butanoate metabolism|Terpenoid backbone biosynthesis|PPAR signaling pathway" HMGN1 4913.582695 4091.9478 5735.217589 1.401586205 0.487060481 0.042596375 1 65.09082964 89.70379156 3150 high mobility group nucleosome binding domain 1 "GO:0000785,GO:0003677,GO:0003682,GO:0005634,GO:0005654,GO:0005737,GO:0006283,GO:0006325,GO:0031492,GO:0032786" "chromatin|DNA binding|chromatin binding|nucleus|nucleoplasm|cytoplasm|transcription-coupled nucleotide-excision repair|chromatin organization|nucleosomal DNA binding|positive regulation of DNA-templated transcription, elongation" other HMGN2 4057.650622 3750.692047 4364.609196 1.163681033 0.218695667 0.358751228 1 103.1791449 118.058445 3151 high mobility group nucleosomal binding domain 2 "GO:0000785,GO:0003682,GO:0003723,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0006325,GO:0031492,GO:0031640,GO:0061844" chromatin|chromatin binding|RNA binding|protein binding|extracellular space|nucleus|cytoplasm|chromatin organization|nucleosomal DNA binding|killing of cells of other organism|antimicrobial humoral immune response mediated by antimicrobial peptide HMGN3 461.0794146 484.8328693 437.32596 0.902013844 -0.148778519 0.597588477 1 18.29889615 16.22965447 9324 high mobility group nucleosomal binding domain 3 "GO:0000785,GO:0003682,GO:0005634,GO:0005654,GO:0005829,GO:0006325,GO:0008150,GO:0031492,GO:0045944,GO:0046966,GO:0061178" chromatin|chromatin binding|nucleus|nucleoplasm|cytosol|chromatin organization|biological_process|nucleosomal DNA binding|positive regulation of transcription by RNA polymerase II|thyroid hormone receptor binding|regulation of insulin secretion involved in cellular response to glucose stimulus other HMGN4 2306.068193 2050.655763 2561.480623 1.249103174 0.320892647 0.174677251 1 48.14770308 59.13506306 10473 high mobility group nucleosomal binding domain 4 "GO:0000785,GO:0003682,GO:0005515,GO:0005634,GO:0006325,GO:0031492" chromatin|chromatin binding|protein binding|nucleus|chromatin organization|nucleosomal DNA binding HMGN5 226.7523189 199.7594655 253.7451724 1.270253561 0.345116509 0.32186277 1 5.078987865 6.343643594 79366 high mobility group nucleosome binding domain 5 "GO:0000785,GO:0003682,GO:0003723,GO:0005634,GO:0005654,GO:0005739,GO:0006325,GO:0006355,GO:0008284,GO:0010628,GO:0031492,GO:0043066,GO:0045893,GO:0071157" "chromatin|chromatin binding|RNA binding|nucleus|nucleoplasm|mitochondrion|chromatin organization|regulation of transcription, DNA-templated|positive regulation of cell population proliferation|positive regulation of gene expression|nucleosomal DNA binding|negative regulation of apoptotic process|positive regulation of transcription, DNA-templated|negative regulation of cell cycle arrest" HMGXB3 1899.395428 2010.079621 1788.711234 0.889870837 -0.168332149 0.477787127 1 20.40210251 17.85143274 22993 HMG-box containing 3 "GO:0003677,GO:0005575,GO:0005634,GO:0008150" DNA binding|cellular_component|nucleus|biological_process HMGXB4 1651.993961 1671.945109 1632.042813 0.976134207 -0.03484858 0.88590356 1 17.82433831 17.10779854 10042 HMG-box containing 4 "GO:0003677,GO:0005515,GO:0008333,GO:0016055,GO:0016589,GO:0030178,GO:0042802" DNA binding|protein binding|endosome to lysosome transport|Wnt signaling pathway|NURF complex|negative regulation of Wnt signaling pathway|identical protein binding HMMR 1830.162016 2084.989421 1575.334612 0.755560002 -0.404381764 0.08799732 1 36.89391689 27.40910806 3161 hyaluronan mediated motility receptor "GO:0005515,GO:0005540,GO:0005813,GO:0005829,GO:0005886,GO:0009986,GO:0010389,GO:0015630,GO:0016020,GO:0030214" protein binding|hyaluronic acid binding|centrosome|cytosol|plasma membrane|cell surface|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|membrane|hyaluronan catabolic process hsa04512 ECM-receptor interaction HMOX1 892.0415469 872.9072475 911.1758463 1.043840395 0.061901139 0.807242362 1 29.97777057 30.76837851 3162 heme oxygenase 1 "GO:0001525,GO:0001935,GO:0002246,GO:0002686,GO:0004392,GO:0004630,GO:0005198,GO:0005515,GO:0005615,GO:0005634,GO:0005730,GO:0005783,GO:0005789,GO:0005829,GO:0005901,GO:0006788,GO:0006879,GO:0006979,GO:0007264,GO:0007588,GO:0008217,GO:0008219,GO:0008630,GO:0010656,GO:0014806,GO:0016020,GO:0016239,GO:0016242,GO:0019221,GO:0019899,GO:0020037,GO:0031670,GO:0032722,GO:0032764,GO:0034101,GO:0034383,GO:0034395,GO:0034605,GO:0035094,GO:0035556,GO:0042167,GO:0042493,GO:0042542,GO:0042802,GO:0042803,GO:0043065,GO:0043123,GO:0043305,GO:0043392,GO:0043433,GO:0043524,GO:0043619,GO:0043627,GO:0045765,GO:0045766,GO:0046872,GO:0048471,GO:0048661,GO:0048662,GO:0051090,GO:0055072,GO:0071243,GO:0071276,GO:0071456,GO:0072719,GO:0090050,GO:0097421,GO:1902042,GO:1903589,GO:1904036,GO:1904706" angiogenesis|endothelial cell proliferation|wound healing involved in inflammatory response|negative regulation of leukocyte migration|heme oxygenase (decyclizing) activity|phospholipase D activity|structural molecule activity|protein binding|extracellular space|nucleus|nucleolus|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|caveola|heme oxidation|cellular iron ion homeostasis|response to oxidative stress|small GTPase mediated signal transduction|excretion|regulation of blood pressure|cell death|intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of muscle cell apoptotic process|smooth muscle hyperplasia|membrane|positive regulation of macroautophagy|negative regulation of macroautophagy|cytokine-mediated signaling pathway|enzyme binding|heme binding|cellular response to nutrient|positive regulation of chemokine production|negative regulation of mast cell cytokine production|erythrocyte homeostasis|low-density lipoprotein particle clearance|regulation of transcription from RNA polymerase II promoter in response to iron|cellular response to heat|response to nicotine|intracellular signal transduction|heme catabolic process|response to drug|response to hydrogen peroxide|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of mast cell degranulation|negative regulation of DNA binding|negative regulation of DNA-binding transcription factor activity|negative regulation of neuron apoptotic process|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to estrogen|regulation of angiogenesis|positive regulation of angiogenesis|metal ion binding|perinuclear region of cytoplasm|positive regulation of smooth muscle cell proliferation|negative regulation of smooth muscle cell proliferation|regulation of DNA-binding transcription factor activity|iron ion homeostasis|cellular response to arsenic-containing substance|cellular response to cadmium ion|cellular response to hypoxia|cellular response to cisplatin|positive regulation of cell migration involved in sprouting angiogenesis|liver regeneration|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|negative regulation of epithelial cell apoptotic process|negative regulation of vascular associated smooth muscle cell proliferation "hsa00860,hsa04066,hsa04216,hsa04978,hsa05200,hsa05206,hsa05225,hsa05418" Porphyrin and chlorophyll metabolism|HIF-1 signaling pathway|Ferroptosis|Mineral absorption|Pathways in cancer|MicroRNAs in cancer|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis HMOX2 1269.535606 1270.345351 1268.725862 0.998725159 -0.001840381 0.997659847 1 26.56582938 26.0879857 3163 heme oxygenase 2 "GO:0001666,GO:0004392,GO:0005515,GO:0005789,GO:0005886,GO:0006788,GO:0006879,GO:0006979,GO:0016020,GO:0020037,GO:0035579,GO:0042167,GO:0043312,GO:0046872,GO:0055072" response to hypoxia|heme oxygenase (decyclizing) activity|protein binding|endoplasmic reticulum membrane|plasma membrane|heme oxidation|cellular iron ion homeostasis|response to oxidative stress|membrane|heme binding|specific granule membrane|heme catabolic process|neutrophil degranulation|metal ion binding|iron ion homeostasis "hsa00860,hsa04978" Porphyrin and chlorophyll metabolism|Mineral absorption HMSD 340.1580465 325.6495453 354.6665478 1.089104999 0.123143049 0.691132382 1 5.541874271 5.934683993 284293 histocompatibility minor serpin domain containing "GO:0002253,GO:0004867,GO:0005615,GO:0010951" activation of immune response|serine-type endopeptidase inhibitor activity|extracellular space|negative regulation of endopeptidase activity HNF1B 35.7854529 43.69738307 27.87352272 0.637876247 -0.648651538 0.346222668 1 0.473993704 0.297289918 6928 HNF1 homeobox B "GO:0000785,GO:0000978,GO:0000981,GO:0001822,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0009743,GO:0014070,GO:0030073,GO:0031016,GO:0032922,GO:0035565,GO:0039020,GO:0042493,GO:0042802,GO:0043231,GO:0044877,GO:0045893,GO:0048598,GO:0048793,GO:0060261,GO:0065004,GO:0070365" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|kidney development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|response to carbohydrate|response to organic cyclic compound|insulin secretion|pancreas development|circadian regulation of gene expression|regulation of pronephros size|pronephric nephron tubule development|response to drug|identical protein binding|intracellular membrane-bounded organelle|protein-containing complex binding|positive regulation of transcription, DNA-templated|embryonic morphogenesis|pronephros development|positive regulation of transcription initiation from RNA polymerase II promoter|protein-DNA complex assembly|hepatocyte differentiation" hsa04950 Maturity onset diabetes of the young Homeobox HNF4G 181.3351848 206.0019488 156.6684208 0.76051912 -0.394943576 0.296895334 1 2.211616453 1.653830999 3174 hepatocyte nuclear factor 4 gamma "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0004879,GO:0005654,GO:0005829,GO:0006357,GO:0006367,GO:0008270,GO:0030154,GO:0030522,GO:0045171,GO:0045944,GO:0048856,GO:0072686" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nuclear receptor activity|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|zinc ion binding|cell differentiation|intracellular receptor signaling pathway|intercellular bridge|positive regulation of transcription by RNA polymerase II|anatomical structure development|mitotic spindle" hsa04950 Maturity onset diabetes of the young ThyrH_rcpt HNMT 3.641448589 7.282897178 0 0 #NAME? 0.060320757 1 0.076965314 0 3176 histamine N-methyltransferase "GO:0001692,GO:0001695,GO:0002347,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006548,GO:0006972,GO:0007420,GO:0007585,GO:0014075,GO:0032259,GO:0035902,GO:0042220,GO:0043005,GO:0046539,GO:0051384,GO:0070062,GO:0070555" histamine metabolic process|histamine catabolic process|response to tumor cell|nucleoplasm|cytoplasm|centrosome|cytosol|histidine catabolic process|hyperosmotic response|brain development|respiratory gaseous exchange by respiratory system|response to amine|methylation|response to immobilization stress|response to cocaine|neuron projection|histamine N-methyltransferase activity|response to glucocorticoid|extracellular exosome|response to interleukin-1 hsa00340 Histidine metabolism HNRNPA0 2574.480498 2524.044079 2624.916916 1.039964768 0.056534654 0.81235466 1 15.46007041 15.80888618 10949 heterogeneous nuclear ribonucleoprotein A0 "GO:0000398,GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0006397,GO:0006954,GO:0016070,GO:0019901,GO:0032496,GO:0035925,GO:0070935" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|nucleoplasm|mRNA processing|inflammatory response|RNA metabolic process|protein kinase binding|response to lipopolysaccharide|mRNA 3'-UTR AU-rich region binding|3'-UTR-mediated mRNA stabilization" HNRNPA1 25089.88786 24965.77153 25214.00419 1.00994292 0.014273757 0.959959031 1 355.8700164 353.3941905 3178 heterogeneous nuclear ribonucleoprotein A1 "GO:0000381,GO:0000398,GO:0003697,GO:0003723,GO:0003727,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0006405,GO:0008543,GO:0016020,GO:0016032,GO:0016070,GO:0019904,GO:0032211,GO:0032212,GO:0035198,GO:0036002,GO:0042149,GO:0051028,GO:0051168,GO:0051170,GO:0061752,GO:0070062,GO:0071013,GO:0098505,GO:1903936,GO:1990904" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|single-stranded DNA binding|RNA binding|single-stranded RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|RNA export from nucleus|fibroblast growth factor receptor signaling pathway|membrane|viral process|RNA metabolic process|protein domain specific binding|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance via telomerase|miRNA binding|pre-mRNA binding|cellular response to glucose starvation|mRNA transport|nuclear export|import into nucleus|telomeric repeat-containing RNA binding|extracellular exosome|catalytic step 2 spliceosome|G-rich strand telomeric DNA binding|cellular response to sodium arsenite|ribonucleoprotein complex" "hsa03040,hsa05014" Spliceosome|Amyotrophic lateral sclerosis HNRNPA1L2 261.7646998 273.6288511 249.9005486 0.913282892 -0.130866286 0.699675631 1 6.351922086 5.704028192 144983 heterogeneous nuclear ribonucleoprotein A1 like 2 "GO:0003723,GO:0005681,GO:0005737,GO:0006397,GO:0008380,GO:0051028" RNA binding|spliceosomal complex|cytoplasm|mRNA processing|RNA splicing|mRNA transport "hsa03040,hsa05014" Spliceosome|Amyotrophic lateral sclerosis HNRNPA2B1 11607.24289 10329.22903 12885.25675 1.247455808 0.318988708 0.211143813 1 150.1639795 184.188333 3181 heterogeneous nuclear ribonucleoprotein A2/B1 "GO:0000122,GO:0000398,GO:0000781,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0006397,GO:0006406,GO:0015030,GO:0016020,GO:0016032,GO:0016070,GO:0016363,GO:0031053,GO:0035198,GO:0035722,GO:0043047,GO:0044806,GO:0048025,GO:0050658,GO:0070062,GO:0071013,GO:0097157,GO:0098505,GO:1904358,GO:1905663,GO:1990247,GO:1990428,GO:1990904" "negative regulation of transcription by RNA polymerase II|mRNA splicing, via spliceosome|chromosome, telomeric region|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|mRNA processing|mRNA export from nucleus|Cajal body|membrane|viral process|RNA metabolic process|nuclear matrix|primary miRNA processing|miRNA binding|interleukin-12-mediated signaling pathway|single-stranded telomeric DNA binding|G-quadruplex DNA unwinding|negative regulation of mRNA splicing, via spliceosome|RNA transport|extracellular exosome|catalytic step 2 spliceosome|pre-mRNA intronic binding|G-rich strand telomeric DNA binding|positive regulation of telomere maintenance via telomere lengthening|positive regulation of telomerase RNA reverse transcriptase activity|N6-methyladenosine-containing RNA binding|miRNA transport|ribonucleoprotein complex" hsa05014 Amyotrophic lateral sclerosis HNRNPA3 10178.2555 9704.980697 10651.5303 1.097532353 0.134263469 0.593848943 1 90.17008754 97.30855002 220988 heterogeneous nuclear ribonucleoprotein A3 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0016070,GO:0071013,GO:1990904" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|RNA metabolic process|catalytic step 2 spliceosome|ribonucleoprotein complex" "hsa03040,hsa05014" Spliceosome|Amyotrophic lateral sclerosis HNRNPAB 3045.708613 2669.702023 3421.715203 1.281684313 0.358040961 0.130636922 1 80.49553122 101.4434518 3182 heterogeneous nuclear ribonucleoprotein A/B "GO:0001837,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0010468,GO:0045893,GO:0090575,GO:1990904" "epithelial to mesenchymal transition|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of gene expression|positive regulation of transcription, DNA-templated|RNA polymerase II transcription regulator complex|ribonucleoprotein complex" HNRNPC 12608.28766 11818.06129 13398.51403 1.13373198 0.18107962 0.481511802 1 140.6261339 156.7644608 3183 heterogeneous nuclear ribonucleoprotein C "GO:0000398,GO:0000785,GO:0001649,GO:0003723,GO:0003730,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005681,GO:0005697,GO:0005829,GO:0008266,GO:0008380,GO:0015629,GO:0016020,GO:0016070,GO:0031492,GO:0032211,GO:0032991,GO:0042802,GO:0043044,GO:0070034,GO:0070062,GO:0070935,GO:0071013,GO:1990247" "mRNA splicing, via spliceosome|chromatin|osteoblast differentiation|RNA binding|mRNA 3'-UTR binding|protein binding|extracellular region|nucleus|nucleoplasm|spliceosomal complex|telomerase holoenzyme complex|cytosol|poly(U) RNA binding|RNA splicing|actin cytoskeleton|membrane|RNA metabolic process|nucleosomal DNA binding|negative regulation of telomere maintenance via telomerase|protein-containing complex|identical protein binding|ATP-dependent chromatin remodeling|telomerase RNA binding|extracellular exosome|3'-UTR-mediated mRNA stabilization|catalytic step 2 spliceosome|N6-methyladenosine-containing RNA binding" hsa03040 Spliceosome HNRNPD 4585.861269 4408.233621 4763.488918 1.080589036 0.111817949 0.640593452 1 76.68165787 81.47478612 3184 heterogeneous nuclear ribonucleoprotein D "GO:0000398,GO:0001889,GO:0003680,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006396,GO:0006401,GO:0008134,GO:0010468,GO:0016070,GO:0021549,GO:0032204,GO:0035925,GO:0042162,GO:0042752,GO:0042826,GO:0043488,GO:0045202,GO:0045727,GO:0045893,GO:0048255,GO:0051592,GO:0051602,GO:0061158,GO:0071230,GO:0071392,GO:0071732,GO:0097167,GO:1901355,GO:1904355,GO:1904383,GO:1904586,GO:1905663,GO:1990828,GO:1990904" "mRNA splicing, via spliceosome|liver development|minor groove of adenine-thymine-rich DNA binding|chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|RNA processing|RNA catabolic process|transcription factor binding|regulation of gene expression|RNA metabolic process|cerebellum development|regulation of telomere maintenance|mRNA 3'-UTR AU-rich region binding|telomeric DNA binding|regulation of circadian rhythm|histone deacetylase binding|regulation of mRNA stability|synapse|positive regulation of translation|positive regulation of transcription, DNA-templated|mRNA stabilization|response to calcium ion|response to electrical stimulus|3'-UTR-mediated mRNA destabilization|cellular response to amino acid stimulus|cellular response to estradiol stimulus|cellular response to nitric oxide|circadian regulation of translation|response to rapamycin|positive regulation of telomere capping|response to sodium phosphate|cellular response to putrescine|positive regulation of telomerase RNA reverse transcriptase activity|hepatocyte dedifferentiation|ribonucleoprotein complex" HNRNPDL 4886.842092 4361.414996 5412.269188 1.240943408 0.311437324 0.194192193 1 53.17813626 64.88678665 9987 heterogeneous nuclear ribonucleoprotein D like "GO:0003677,GO:0003723,GO:0005515,GO:0005654,GO:0005829,GO:0008143,GO:0010468,GO:0034046,GO:0035722" DNA binding|RNA binding|protein binding|nucleoplasm|cytosol|poly(A) binding|regulation of gene expression|poly(G) binding|interleukin-12-mediated signaling pathway HNRNPF 5057.827974 5305.070388 4810.58556 0.906790148 -0.141159379 0.556902973 1 92.04221596 82.06633474 3185 heterogeneous nuclear ribonucleoprotein F "GO:0000398,GO:0003723,GO:0003727,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006396,GO:0008543,GO:0016020,GO:0016070,GO:0017025,GO:0035722,GO:0043484,GO:0071013,GO:1990904" "mRNA splicing, via spliceosome|RNA binding|single-stranded RNA binding|protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|RNA processing|fibroblast growth factor receptor signaling pathway|membrane|RNA metabolic process|TBP-class protein binding|interleukin-12-mediated signaling pathway|regulation of RNA splicing|catalytic step 2 spliceosome|ribonucleoprotein complex" HNRNPH1 3987.044673 3852.652607 4121.436739 1.069765992 0.097295246 0.683402829 1 56.65720275 59.59572331 3187 heterogeneous nuclear ribonucleoprotein H1 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006396,GO:0008266,GO:0008543,GO:0016020,GO:0016070,GO:0042802,GO:0043484,GO:0071013,GO:1990904" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|RNA processing|poly(U) RNA binding|fibroblast growth factor receptor signaling pathway|membrane|RNA metabolic process|identical protein binding|regulation of RNA splicing|catalytic step 2 spliceosome|ribonucleoprotein complex" HNRNPH3 2657.155001 2486.58918 2827.720823 1.137188582 0.185471518 0.43313342 1 47.58146087 53.20365159 3189 heterogeneous nuclear ribonucleoprotein H3 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0006396,GO:0008380,GO:0030855,GO:0043484,GO:1990904" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|RNA processing|RNA splicing|epithelial cell differentiation|regulation of RNA splicing|ribonucleoprotein complex" HNRNPK 13107.40892 12809.57572 13405.24212 1.046501649 0.065574585 0.799815828 1 224.0653928 230.5610174 3190 heterogeneous nuclear ribonucleoprotein K "GO:0000398,GO:0000785,GO:0002102,GO:0003677,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005925,GO:0006357,GO:0006396,GO:0007165,GO:0010468,GO:0010494,GO:0010988,GO:0016020,GO:0016032,GO:0016070,GO:0019904,GO:0042802,GO:0042995,GO:0043066,GO:0045296,GO:0045944,GO:0048024,GO:0048025,GO:0048260,GO:0070062,GO:0071013,GO:1902165,GO:1905599" "mRNA splicing, via spliceosome|chromatin|podosome|DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|focal adhesion|regulation of transcription by RNA polymerase II|RNA processing|signal transduction|regulation of gene expression|cytoplasmic stress granule|regulation of low-density lipoprotein particle clearance|membrane|viral process|RNA metabolic process|protein domain specific binding|identical protein binding|cell projection|negative regulation of apoptotic process|cadherin binding|positive regulation of transcription by RNA polymerase II|regulation of mRNA splicing, via spliceosome|negative regulation of mRNA splicing, via spliceosome|positive regulation of receptor-mediated endocytosis|extracellular exosome|catalytic step 2 spliceosome|regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of low-density lipoprotein receptor activity" "hsa03040,hsa05203,hsa05206" Spliceosome|Viral carcinogenesis|MicroRNAs in cancer HNRNPL 3784.455231 3618.559484 3950.350979 1.091691596 0.126565351 0.594971106 1 74.64857712 80.12954558 3191 heterogeneous nuclear ribonucleoprotein L "GO:0000381,GO:0000398,GO:0000976,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006396,GO:0006417,GO:0016020,GO:0016070,GO:0035770,GO:0043484,GO:0070062,GO:0097157,GO:1990904" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|transcription regulatory region sequence-specific DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|RNA processing|regulation of translation|membrane|RNA metabolic process|ribonucleoprotein granule|regulation of RNA splicing|extracellular exosome|pre-mRNA intronic binding|ribonucleoprotein complex" other HNRNPLL 399.7597766 300.6796121 498.8399412 1.659041455 0.730349936 0.011725394 0.643952702 3.417831368 5.575438734 92906 heterogeneous nuclear ribonucleoprotein L like "GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0006397,GO:0006417,GO:0016020,GO:0033120,GO:0043484" RNA binding|mRNA binding|protein binding|nucleus|mRNA processing|regulation of translation|membrane|positive regulation of RNA splicing|regulation of RNA splicing HNRNPM 3663.558401 3497.871473 3829.245329 1.094735858 0.130582813 0.583018818 1 61.83337917 66.55849655 4670 heterogeneous nuclear ribonucleoprotein M "GO:0000380,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005730,GO:0005737,GO:0008543,GO:0016020,GO:0016070,GO:0016363,GO:0019904,GO:0042382,GO:0062023,GO:0070062,GO:0071013,GO:0071014,GO:1990904,GO:2000815" "alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|nucleolus|cytoplasm|fibroblast growth factor receptor signaling pathway|membrane|RNA metabolic process|nuclear matrix|protein domain specific binding|paraspeckles|collagen-containing extracellular matrix|extracellular exosome|catalytic step 2 spliceosome|post-mRNA release spliceosomal complex|ribonucleoprotein complex|regulation of mRNA stability involved in response to oxidative stress" hsa03040 Spliceosome HNRNPR 4134.066322 3940.047374 4328.08527 1.098485592 0.135515947 0.57004219 1 27.09704727 29.26762705 10236 heterogeneous nuclear ribonucleoprotein R "GO:0000398,GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005730,GO:0005783,GO:0006397,GO:0007623,GO:0016070,GO:0030425,GO:0030426,GO:0043086,GO:0043679,GO:0061157,GO:0071013,GO:1990904" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|nucleolus|endoplasmic reticulum|mRNA processing|circadian rhythm|RNA metabolic process|dendrite|growth cone|negative regulation of catalytic activity|axon terminus|mRNA destabilization|catalytic step 2 spliceosome|ribonucleoprotein complex" HNRNPU 8899.302179 9146.278442 8652.325916 0.945994152 -0.08009683 0.747706634 1 71.08199655 66.11792993 3192 heterogeneous nuclear ribonucleoprotein U "GO:0000122,GO:0000228,GO:0000381,GO:0000398,GO:0000776,GO:0000777,GO:0000922,GO:0000978,GO:0000993,GO:0001097,GO:0001649,GO:0003677,GO:0003682,GO:0003690,GO:0003697,GO:0003714,GO:0003723,GO:0003725,GO:0003727,GO:0003730,GO:0003779,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005697,GO:0005813,GO:0006325,GO:0006396,GO:0007049,GO:0007346,GO:0008143,GO:0009048,GO:0009986,GO:0016020,GO:0016032,GO:0016070,GO:0016363,GO:0016607,GO:0017069,GO:0017130,GO:0030496,GO:0031490,GO:0032211,GO:0032839,GO:0032922,GO:0032991,GO:0033673,GO:0034046,GO:0034244,GO:0036002,GO:0036464,GO:0042802,GO:0043021,GO:0044877,GO:0045944,GO:0048255,GO:0051301,GO:0051457,GO:0055013,GO:0070034,GO:0070934,GO:0070937,GO:0071013,GO:0071385,GO:0072686,GO:0090336,GO:0090575,GO:0098577,GO:0098963,GO:0099122,GO:1901673,GO:1902275,GO:1902425,GO:1902889,GO:1990023,GO:1990280,GO:1990498,GO:1990830,GO:1990837,GO:1990841,GO:1990845,GO:1990904,GO:2000373,GO:2000648,GO:2000737" "negative regulation of transcription by RNA polymerase II|nuclear chromosome|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|kinetochore|condensed chromosome kinetochore|spindle pole|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II complex binding|TFIIH-class transcription factor complex binding|osteoblast differentiation|DNA binding|chromatin binding|double-stranded DNA binding|single-stranded DNA binding|transcription corepressor activity|RNA binding|double-stranded RNA binding|single-stranded RNA binding|mRNA 3'-UTR binding|actin binding|protein binding|ATP binding|nucleus|nucleoplasm|telomerase holoenzyme complex|centrosome|chromatin organization|RNA processing|cell cycle|regulation of mitotic cell cycle|poly(A) binding|dosage compensation by inactivation of X chromosome|cell surface|membrane|viral process|RNA metabolic process|nuclear matrix|nuclear speck|snRNA binding|poly(C) RNA binding|midbody|chromatin DNA binding|negative regulation of telomere maintenance via telomerase|dendrite cytoplasm|circadian regulation of gene expression|protein-containing complex|negative regulation of kinase activity|poly(G) binding|negative regulation of transcription elongation from RNA polymerase II promoter|pre-mRNA binding|cytoplasmic ribonucleoprotein granule|identical protein binding|ribonucleoprotein complex binding|protein-containing complex binding|positive regulation of transcription by RNA polymerase II|mRNA stabilization|cell division|maintenance of protein location in nucleus|cardiac muscle cell development|telomerase RNA binding|CRD-mediated mRNA stabilization|CRD-mediated mRNA stability complex|catalytic step 2 spliceosome|cellular response to glucocorticoid stimulus|mitotic spindle|positive regulation of brown fat cell differentiation|RNA polymerase II transcription regulator complex|inactive sex chromosome|dendritic transport of messenger ribonucleoprotein complex|RNA polymerase II C-terminal domain binding|regulation of mitotic spindle assembly|regulation of chromatin organization|positive regulation of attachment of mitotic spindle microtubules to kinetochore|protein localization to spindle microtubule|mitotic spindle midzone|RNA localization to chromatin|mitotic spindle microtubule|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding|adaptive thermogenesis|ribonucleoprotein complex|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity|positive regulation of stem cell proliferation|negative regulation of stem cell differentiation" hsa03040 Spliceosome HNRNPUL1 4741.259106 4778.620963 4703.897249 0.984362912 -0.022737792 0.925246952 1 53.71234584 51.98769249 11100 heterogeneous nuclear ribonucleoprotein U like 1 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006396,GO:0009615,GO:0019899" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|RNA processing|response to virus|enzyme binding" hsa05164 Influenza A HNRNPUL2 4799.902752 4249.050297 5350.755207 1.259282624 0.332602107 0.16531817 1 43.49137033 53.85145986 221092 heterogeneous nuclear ribonucleoprotein U like 2 "GO:0003723,GO:0005634,GO:0005654,GO:0008150,GO:0016020" RNA binding|nucleus|nucleoplasm|biological_process|membrane HOGA1 26.61987277 30.1720026 23.06774294 0.764541328 -0.387333604 0.639127933 1 0.65938752 0.495693094 112817 4-hydroxy-2-oxoglutarate aldolase 1 "GO:0005515,GO:0005739,GO:0005759,GO:0008700,GO:0009436,GO:0019470,GO:0033609,GO:0042803,GO:0042866,GO:0046487" protein binding|mitochondrion|mitochondrial matrix|4-hydroxy-2-oxoglutarate aldolase activity|glyoxylate catabolic process|4-hydroxyproline catabolic process|oxalate metabolic process|protein homodimerization activity|pyruvate biosynthetic process|glyoxylate metabolic process "hsa00330,hsa00630" Arginine and proline metabolism|Glyoxylate and dicarboxylate metabolism HOMER1 234.2578986 258.0226429 210.4931544 0.815793343 -0.293724361 0.39433896 1 1.919993618 1.540107801 9456 homer scaffold protein 1 "GO:0003009,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007206,GO:0007216,GO:0007268,GO:0009967,GO:0014069,GO:0030018,GO:0030424,GO:0030425,GO:0035256,GO:0035591,GO:0043034,GO:0043197,GO:0044309,GO:0044325,GO:0045177,GO:0048148,GO:0048741,GO:0048875,GO:0051262,GO:0051592,GO:0051928,GO:0051966,GO:0090279,GO:0098962,GO:0098978,GO:0099524,GO:1902950,GO:2001256,GO:2001257" "skeletal muscle contraction|protein binding|cytoplasm|cytosol|plasma membrane|phospholipase C-activating G protein-coupled glutamate receptor signaling pathway|G protein-coupled glutamate receptor signaling pathway|chemical synaptic transmission|positive regulation of signal transduction|postsynaptic density|Z disc|axon|dendrite|G protein-coupled glutamate receptor binding|signaling adaptor activity|costamere|dendritic spine|neuron spine|ion channel binding|apical part of cell|behavioral response to cocaine|skeletal muscle fiber development|chemical homeostasis within a tissue|protein tetramerization|response to calcium ion|positive regulation of calcium ion transport|regulation of synaptic transmission, glutamatergic|regulation of calcium ion import|regulation of postsynaptic neurotransmitter receptor activity|glutamatergic synapse|postsynaptic cytosol|regulation of dendritic spine maintenance|regulation of store-operated calcium entry|regulation of cation channel activity" "hsa04068,hsa04724" FoxO signaling pathway|Glutamatergic synapse HOMER2 1075.9136 1044.575538 1107.251661 1.060001523 0.084066338 0.733541251 1 4.219746925 4.398089604 9455 homer scaffold protein 2 "GO:0003779,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007216,GO:0007605,GO:0008277,GO:0014069,GO:0019904,GO:0030160,GO:0030425,GO:0032426,GO:0032703,GO:0035256,GO:0035584,GO:0042802,GO:0043025,GO:0043229,GO:0044877,GO:0045177,GO:0048148,GO:0048875,GO:0070885,GO:0098978,GO:2001256" actin binding|protein binding|cytoplasm|cytosol|plasma membrane|G protein-coupled glutamate receptor signaling pathway|sensory perception of sound|regulation of G protein-coupled receptor signaling pathway|postsynaptic density|protein domain specific binding|synaptic receptor adaptor activity|dendrite|stereocilium tip|negative regulation of interleukin-2 production|G protein-coupled glutamate receptor binding|calcium-mediated signaling using intracellular calcium source|identical protein binding|neuronal cell body|intracellular organelle|protein-containing complex binding|apical part of cell|behavioral response to cocaine|chemical homeostasis within a tissue|negative regulation of calcineurin-NFAT signaling cascade|glutamatergic synapse|regulation of store-operated calcium entry "hsa04068,hsa04724" FoxO signaling pathway|Glutamatergic synapse HOMER3 1171.266184 1049.777608 1292.754761 1.231455835 0.300364888 0.215799788 1 24.60461199 29.79247204 9454 homer scaffold protein 3 "GO:0005515,GO:0005575,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0007216,GO:0014069,GO:0030425,GO:0032703,GO:0035256,GO:0042802,GO:0070885,GO:2001256" protein binding|cellular_component|cytoplasm|cytosol|plasma membrane|protein targeting|G protein-coupled glutamate receptor signaling pathway|postsynaptic density|dendrite|negative regulation of interleukin-2 production|G protein-coupled glutamate receptor binding|identical protein binding|negative regulation of calcineurin-NFAT signaling cascade|regulation of store-operated calcium entry "hsa04068,hsa04724" FoxO signaling pathway|Glutamatergic synapse HOMEZ 118.3700232 130.0517353 106.6883111 0.820352845 -0.285683528 0.525259383 1 1.39202208 1.122840299 57594 homeobox and leucine zipper encoding "GO:0000785,GO:0000981,GO:0003677,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II" HOOK2 236.7450769 247.6185041 225.8716497 0.912175972 -0.132615927 0.706554615 1 5.198640621 4.662722858 29911 hook microtubule tethering protein 2 "GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005874,GO:0006897,GO:0007032,GO:0007040,GO:0008017,GO:0008333,GO:0015031,GO:0030705,GO:0030897,GO:0031122,GO:0042802,GO:0043231,GO:0045022,GO:0051959,GO:0070695" protein binding|cytoplasm|centrosome|cytosol|microtubule|endocytosis|endosome organization|lysosome organization|microtubule binding|endosome to lysosome transport|protein transport|cytoskeleton-dependent intracellular transport|HOPS complex|cytoplasmic microtubule organization|identical protein binding|intracellular membrane-bounded organelle|early endosome to late endosome transport|dynein light intermediate chain binding|FHF complex HOOK3 983.9948726 965.5040831 1002.485662 1.038302872 0.054227337 0.829373863 1 3.591244661 3.666403232 84376 hook microtubule tethering protein 3 "GO:0000242,GO:0005515,GO:0005737,GO:0005801,GO:0005813,GO:0005829,GO:0005874,GO:0007032,GO:0007040,GO:0008017,GO:0008333,GO:0015031,GO:0022027,GO:0030705,GO:0030897,GO:0031122,GO:0034451,GO:0034452,GO:0034454,GO:0042802,GO:0045022,GO:0045503,GO:0045505,GO:0050768,GO:0051645,GO:0051959,GO:0070695,GO:0071539,GO:0097150" pericentriolar material|protein binding|cytoplasm|cis-Golgi network|centrosome|cytosol|microtubule|endosome organization|lysosome organization|microtubule binding|endosome to lysosome transport|protein transport|interkinetic nuclear migration|cytoskeleton-dependent intracellular transport|HOPS complex|cytoplasmic microtubule organization|centriolar satellite|dynactin binding|microtubule anchoring at centrosome|identical protein binding|early endosome to late endosome transport|dynein light chain binding|dynein intermediate chain binding|negative regulation of neurogenesis|Golgi localization|dynein light intermediate chain binding|FHF complex|protein localization to centrosome|neuronal stem cell population maintenance HOPX 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.039566492 0.035940693 84525 HOP homeobox "GO:0000785,GO:0000981,GO:0001829,GO:0003677,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0045596,GO:0051131" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|trophectodermal cell differentiation|DNA binding|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|negative regulation of cell differentiation|chaperone-mediated protein complex assembly" HORMAD1 17.6128085 20.80827765 14.41733934 0.692865579 -0.529352609 0.586301677 1 0.517956872 0.35286921 84072 HORMA domain containing 1 "GO:0000795,GO:0001824,GO:0005515,GO:0005634,GO:0005694,GO:0007130,GO:0007283,GO:0042138,GO:0048477,GO:0051177,GO:0051321,GO:0051598,GO:0060629" synaptonemal complex|blastocyst development|protein binding|nucleus|chromosome|synaptonemal complex assembly|spermatogenesis|meiotic DNA double-strand break formation|oogenesis|meiotic sister chromatid cohesion|meiotic cell cycle|meiotic recombination checkpoint|regulation of homologous chromosome segregation HORMAD2 3.562190663 5.202069413 1.922311912 0.369528309 -1.436243205 0.543489417 1 0.068212502 0.024784655 150280 HORMA domain containing 2 "GO:0000795,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005813,GO:0005829,GO:0051177,GO:0051321" synaptonemal complex|protein binding|nucleus|nucleoplasm|chromosome|centrosome|cytosol|meiotic sister chromatid cohesion|meiotic cell cycle HOXA1 298.3974522 301.720026 295.0748785 0.977975782 -0.032129355 0.930023887 1 6.331987121 6.088906455 3198 homeobox A1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0007275,GO:0007605,GO:0007634,GO:0009653,GO:0021599,GO:0042473,GO:0042802,GO:0043565,GO:0045944,GO:0048702,GO:0048839,GO:0048844,GO:0050795,GO:0050890,GO:0050905,GO:0060840,GO:0060876,GO:0090102,GO:0090103,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|sensory perception of sound|optokinetic behavior|anatomical structure morphogenesis|abducens nerve formation|outer ear morphogenesis|identical protein binding|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|embryonic neurocranium morphogenesis|inner ear development|artery morphogenesis|regulation of behavior|cognition|neuromuscular process|artery development|semicircular canal formation|cochlea development|cochlea morphogenesis|sequence-specific double-stranded DNA binding" hsa04550 Signaling pathways regulating pluripotency of stem cells Homeobox HOXA10 141.3981372 129.0113214 153.784953 1.192026802 0.253416675 0.549163862 1 2.709601382 3.175869177 3206 homeobox A10 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001501,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006357,GO:0007275,GO:0007283,GO:0007338,GO:0008584,GO:0009952,GO:0009954,GO:0030326,GO:0042826,GO:0045944,GO:0060065,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|skeletal system development|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|regulation of transcription by RNA polymerase II|multicellular organism development|spermatogenesis|single fertilization|male gonad development|anterior/posterior pattern specification|proximal/distal pattern formation|embryonic limb morphogenesis|histone deacetylase binding|positive regulation of transcription by RNA polymerase II|uterus development|sequence-specific double-stranded DNA binding" hsa05202 Transcriptional misregulation in cancer HOXA13 88.20808146 44.73779695 131.678366 2.943335947 1.557452218 0.001823008 0.268593592 0.47608654 1.377834061 3209 homeobox A13 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001501,GO:0001570,GO:0001886,GO:0001894,GO:0003281,GO:0003677,GO:0005654,GO:0005694,GO:0006357,GO:0030510,GO:0030539,GO:0035115,GO:0043565,GO:0045111,GO:0045840,GO:0045944,GO:0048839,GO:0048844,GO:0060442,GO:0060847,GO:1990837,GO:2001055" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|skeletal system development|vasculogenesis|endothelial cell morphogenesis|tissue homeostasis|ventricular septum development|DNA binding|nucleoplasm|chromosome|regulation of transcription by RNA polymerase II|regulation of BMP signaling pathway|male genitalia development|embryonic forelimb morphogenesis|sequence-specific DNA binding|intermediate filament cytoskeleton|positive regulation of mitotic nuclear division|positive regulation of transcription by RNA polymerase II|inner ear development|artery morphogenesis|branching involved in prostate gland morphogenesis|endothelial cell fate specification|sequence-specific double-stranded DNA binding|positive regulation of mesenchymal cell apoptotic process" Homeobox HOXA2 33.26870654 28.09117483 38.44623824 1.368623366 0.452725483 0.535942439 1 0.889190019 1.196601954 3199 homeobox A2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001709,GO:0002076,GO:0005634,GO:0005654,GO:0006357,GO:0007379,GO:0008045,GO:0009952,GO:0009953,GO:0021568,GO:0021658,GO:0035284,GO:0042474,GO:0043231,GO:0045665,GO:0045668,GO:0045944,GO:0048703,GO:0071300,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|cell fate determination|osteoblast development|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|segment specification|motor neuron axon guidance|anterior/posterior pattern specification|dorsal/ventral pattern formation|rhombomere 2 development|rhombomere 3 morphogenesis|brain segmentation|middle ear morphogenesis|intracellular membrane-bounded organelle|negative regulation of neuron differentiation|negative regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|embryonic viscerocranium morphogenesis|cellular response to retinoic acid|sequence-specific double-stranded DNA binding" HOXA3 263.850558 265.3055401 262.395576 0.98903165 -0.015911406 0.974287966 1 2.755179814 2.679361521 3200 homeobox A3 "GO:0000785,GO:0000978,GO:0000981,GO:0001525,GO:0001974,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008284,GO:0009952,GO:0010159,GO:0010467,GO:0021615,GO:0030878,GO:0048538,GO:0048645,GO:0048704,GO:0051216,GO:0060017,GO:0071837,GO:1900122" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|angiogenesis|blood vessel remodeling|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|positive regulation of cell population proliferation|anterior/posterior pattern specification|specification of animal organ position|gene expression|glossopharyngeal nerve morphogenesis|thyroid gland development|thymus development|animal organ formation|embryonic skeletal system morphogenesis|cartilage development|parathyroid gland development|HMG box domain binding|positive regulation of receptor binding" HOXA4 147.606022 127.9709076 167.2411363 1.306868409 0.386113881 0.347401486 1 4.048353371 5.202133012 3201 homeobox A4 "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0009653,GO:0009952,GO:0016604,GO:0048704,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|anterior/posterior pattern specification|nuclear body|embryonic skeletal system morphogenesis|sequence-specific double-stranded DNA binding" Homeobox HOXA5 117.6963308 112.3646993 123.0279624 1.094898692 0.130797388 0.783485619 1 3.590836818 3.865812492 3202 homeobox A5 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003016,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0009952,GO:0010628,GO:0016477,GO:0016525,GO:0030878,GO:0033599,GO:0035264,GO:0043065,GO:0045639,GO:0045647,GO:0045944,GO:0048286,GO:0048704,GO:0060435,GO:0060441,GO:0060480,GO:0060484,GO:0060535,GO:0060574,GO:0060638,GO:0060644,GO:0060749,GO:0060764,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|respiratory system process|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|positive regulation of gene expression|cell migration|negative regulation of angiogenesis|thyroid gland development|regulation of mammary gland epithelial cell proliferation|multicellular organism growth|positive regulation of apoptotic process|positive regulation of myeloid cell differentiation|negative regulation of erythrocyte differentiation|positive regulation of transcription by RNA polymerase II|lung alveolus development|embryonic skeletal system morphogenesis|bronchiole development|epithelial tube branching involved in lung morphogenesis|lung goblet cell differentiation|lung-associated mesenchyme development|trachea cartilage morphogenesis|intestinal epithelial cell maturation|mesenchymal-epithelial cell signaling|mammary gland epithelial cell differentiation|mammary gland alveolus development|cell-cell signaling involved in mammary gland development|sequence-specific double-stranded DNA binding" Homeobox HOXA6 8.407599406 6.242483296 10.57271552 1.693671415 0.760154008 0.593857288 1 0.336855268 0.560975223 3203 homeobox A6 "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0005654,GO:0006357,GO:0009952,GO:0016607,GO:0048704,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|nuclear speck|embryonic skeletal system morphogenesis|sequence-specific double-stranded DNA binding" Homeobox HOXA7 7.124381325 10.40413883 3.844623824 0.369528309 -1.436243205 0.311438224 1 0.275421511 0.100072961 3204 homeobox A7 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001525,GO:0001953,GO:0002686,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008134,GO:0009952,GO:0031965,GO:0043565,GO:0045617,GO:0045656,GO:0045892,GO:0045944,GO:0048704,GO:0048863,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|negative regulation of cell-matrix adhesion|negative regulation of leukocyte migration|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription factor binding|anterior/posterior pattern specification|nuclear membrane|sequence-specific DNA binding|negative regulation of keratinocyte differentiation|negative regulation of monocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|stem cell differentiation|sequence-specific double-stranded DNA binding" Homeobox HOXA9 98.12158147 90.51600779 105.7271552 1.168049252 0.224101108 0.647825443 1 2.340442333 2.688006279 3205 homeobox A9 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006351,GO:0006357,GO:0007275,GO:0007283,GO:0007338,GO:0008584,GO:0009952,GO:0009954,GO:0019899,GO:0030879,GO:0035115,GO:0042118,GO:0045638,GO:0045944,GO:0048704,GO:0060065,GO:0060216,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|spermatogenesis|single fertilization|male gonad development|anterior/posterior pattern specification|proximal/distal pattern formation|enzyme binding|mammary gland development|embryonic forelimb morphogenesis|endothelial cell activation|negative regulation of myeloid cell differentiation|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|uterus development|definitive hemopoiesis|sequence-specific double-stranded DNA binding" hsa05202 Transcriptional misregulation in cancer Homeobox HOXB13 248.2047208 233.0527097 263.3567319 1.130030765 0.176362051 0.606332192 1 4.092660344 4.547441799 10481 homeobox B13 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001525,GO:0005515,GO:0005654,GO:0005667,GO:0006357,GO:0008327,GO:0008544,GO:0009611,GO:0033574,GO:0040008,GO:0043565,GO:0060527,GO:0060743,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|angiogenesis|protein binding|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|methyl-CpG binding|epidermis development|response to wounding|response to testosterone|regulation of growth|sequence-specific DNA binding|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|epithelial cell maturation involved in prostate gland development|sequence-specific double-stranded DNA binding" Homeobox HOXB2 483.2853812 436.9738307 529.5969318 1.21196487 0.277347881 0.315246059 1 13.23523849 15.77222564 3212 homeobox B2 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0002011,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007275,GO:0008015,GO:0009952,GO:0009953,GO:0021569,GO:0021570,GO:0021612,GO:0043565,GO:0045944,GO:0048704,GO:0048857,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|morphogenesis of an epithelial sheet|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|multicellular organism development|blood circulation|anterior/posterior pattern specification|dorsal/ventral pattern formation|rhombomere 3 development|rhombomere 4 development|facial nerve structural organization|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|neural nucleus development|sequence-specific double-stranded DNA binding" HOXB3 602.6461285 593.0359131 612.256344 1.032410231 0.046016343 0.867085988 1 3.613751625 3.668443023 3213 homeobox B3 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001525,GO:0002244,GO:0005634,GO:0005654,GO:0006357,GO:0009952,GO:0021546,GO:0021615,GO:0030878,GO:0045944,GO:0048704,GO:0050767,GO:0051216,GO:0060216,GO:0060324" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|hematopoietic progenitor cell differentiation|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|rhombomere development|glossopharyngeal nerve morphogenesis|thyroid gland development|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|regulation of neurogenesis|cartilage development|definitive hemopoiesis|face development" HOXB4 609.7063432 563.9043244 655.508362 1.162446063 0.217163778 0.409160236 1 15.03223645 17.18175762 3214 homeobox B4 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0002011,GO:0005634,GO:0005654,GO:0005813,GO:0006357,GO:0008283,GO:0009952,GO:0045944,GO:0048103,GO:0048536,GO:0048539,GO:0048704,GO:0060216,GO:0060218,GO:1990837,GO:2000738" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|morphogenesis of an epithelial sheet|nucleus|nucleoplasm|centrosome|regulation of transcription by RNA polymerase II|cell population proliferation|anterior/posterior pattern specification|positive regulation of transcription by RNA polymerase II|somatic stem cell division|spleen development|bone marrow development|embryonic skeletal system morphogenesis|definitive hemopoiesis|hematopoietic stem cell differentiation|sequence-specific double-stranded DNA binding|positive regulation of stem cell differentiation" Homeobox HOXB5 136.7213051 107.1626299 166.2799804 1.551660131 0.633812591 0.1313784 1 3.076424208 4.693685647 3215 homeobox B5 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0009653,GO:0009952,GO:0045446,GO:0045944,GO:0048704,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|fibrillar center|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|anterior/posterior pattern specification|endothelial cell differentiation|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|sequence-specific double-stranded DNA binding" HOXB6 400.9285238 381.8318949 420.0251528 1.100026369 0.137538107 0.639514161 1 9.166741545 9.914921062 3216 homeobox B6 "GO:0000785,GO:0000978,GO:0000981,GO:0003723,GO:0005515,GO:0005634,GO:0006357,GO:0009952,GO:0034101,GO:0048704,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|erythrocyte homeostasis|embryonic skeletal system morphogenesis|sequence-specific double-stranded DNA binding" HOXB7 294.9642093 274.669265 315.2591536 1.147777322 0.198842775 0.534502463 1 10.75465433 12.13738909 3217 homeobox B7 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006357,GO:0007275,GO:0009952,GO:0016604,GO:0030099,GO:0045944,GO:0048704,GO:0090190,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|anterior/posterior pattern specification|nuclear body|myeloid cell differentiation|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|positive regulation of branching involved in ureteric bud morphogenesis|sequence-specific double-stranded DNA binding" Homeobox HOXB8 173.1508823 142.5367019 203.7650627 1.42956207 0.515573262 0.180240445 1 1.841869688 2.589006233 3218 homeobox B8 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0005654,GO:0006357,GO:0007625,GO:0008344,GO:0009952,GO:0019233,GO:0021516,GO:0045638,GO:0048704,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|grooming behavior|adult locomotory behavior|anterior/posterior pattern specification|sensory perception of pain|dorsal spinal cord development|negative regulation of myeloid cell differentiation|embryonic skeletal system morphogenesis|sequence-specific double-stranded DNA binding" HOXB9 646.0862305 623.2079157 668.9645454 1.07342113 0.102216193 0.697852208 1 12.86135385 13.57463015 3219 homeobox B9 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006351,GO:0006357,GO:0009952,GO:0009954,GO:0030879,GO:0045944,GO:0048704,GO:0060326,GO:0090575,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|proximal/distal pattern formation|mammary gland development|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|cell chemotaxis|RNA polymerase II transcription regulator complex|sequence-specific double-stranded DNA binding" HOXC10 61.6127464 53.06110801 70.16438479 1.322331693 0.403084107 0.479078841 1 1.433083913 1.863301813 3226 homeobox C10 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001501,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008284,GO:0009952,GO:0009954,GO:0016604,GO:0021520,GO:0030326,GO:0045944,GO:0050905,GO:0120163,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|skeletal system development|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|positive regulation of cell population proliferation|anterior/posterior pattern specification|proximal/distal pattern formation|nuclear body|spinal cord motor neuron cell fate specification|embryonic limb morphogenesis|positive regulation of transcription by RNA polymerase II|neuromuscular process|negative regulation of cold-induced thermogenesis|sequence-specific double-stranded DNA binding" HOXC13 147.754477 157.1024963 138.4064577 0.880994643 -0.182794848 0.664699888 1 3.557179247 3.081415028 3229 homeobox C13 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001942,GO:0003682,GO:0005515,GO:0005634,GO:0006357,GO:0009653,GO:0009952,GO:0035878,GO:0043587,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|hair follicle development|chromatin binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|anterior/posterior pattern specification|nail development|tongue morphogenesis|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" HOXC4 239.3366651 176.87036 301.8029702 1.706351308 0.770914703 0.02365827 0.846928903 4.013284882 6.733480664 3221 homeobox C4 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0009952,GO:0045944,GO:0048704,GO:0051216,GO:0071837,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|cartilage development|HMG box domain binding|sequence-specific double-stranded DNA binding" HOXC5 65.01139079 66.58648849 63.4362931 0.952690171 -0.069920991 0.927432315 1 2.20583396 2.066310972 3222 homeobox C5 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0009952,GO:0030054" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|cell junction" HOXC6 330.318774 294.4371288 366.2004192 1.243730438 0.314673835 0.304516692 1 7.214677875 8.822961556 3223 homeobox C6 "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007275,GO:0009952,GO:0048706" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|multicellular organism development|anterior/posterior pattern specification|embryonic skeletal system development" Homeobox HOXC8 143.3550477 142.5367019 144.1733934 1.011482597 0.016471498 0.987422873 1 3.147257679 3.130126543 3224 homeobox C8 "GO:0000785,GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007275,GO:0015630,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|multicellular organism development|microtubule cytoskeleton|sequence-specific double-stranded DNA binding" Homeobox HOXC9 148.6068069 129.0113214 168.2022923 1.303779315 0.382699692 0.35052617 1 4.671029249 5.988083557 3225 homeobox C9 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006351,GO:0006357,GO:0009952,GO:0009954,GO:0016235,GO:0048704,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|proximal/distal pattern formation|aggresome|embryonic skeletal system morphogenesis|sequence-specific double-stranded DNA binding" HOXD1 112.6578077 93.63724944 131.678366 1.406260508 0.491863877 0.27560049 1 2.649654244 3.663752817 3231 homeobox D1 "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0005654,GO:0006357,GO:0019233,GO:0030182,GO:0048706,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|sensory perception of pain|neuron differentiation|embryonic skeletal system development|sequence-specific double-stranded DNA binding" hsa04550 Signaling pathways regulating pluripotency of stem cells HOXD10 136.7458429 145.6579436 127.8337421 0.877629733 -0.188315691 0.664694242 1 4.354900135 3.758034019 3236 homeobox D10 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007338,GO:0007519,GO:0008344,GO:0009952,GO:0009954,GO:0021520,GO:0030326,GO:0035136,GO:0035137,GO:0036464,GO:0045944,GO:0048704,GO:0048935,GO:0050905,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|chromatin binding|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|single fertilization|skeletal muscle tissue development|adult locomotory behavior|anterior/posterior pattern specification|proximal/distal pattern formation|spinal cord motor neuron cell fate specification|embryonic limb morphogenesis|forelimb morphogenesis|hindlimb morphogenesis|cytoplasmic ribonucleoprotein granule|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|peripheral nervous system neuron development|neuromuscular process|sequence-specific double-stranded DNA binding" "hsa05205,hsa05206" Proteoglycans in cancer|MicroRNAs in cancer HOXD11 177.743426 174.7895323 180.6973197 1.033799435 0.047956319 0.915038065 1 5.47108275 5.561356718 3237 homeobox D11 "GO:0000785,GO:0000978,GO:0000981,GO:0001658,GO:0005634,GO:0005654,GO:0006357,GO:0009953,GO:0048856,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|branching involved in ureteric bud morphogenesis|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|dorsal/ventral pattern formation|anatomical structure development|sequence-specific double-stranded DNA binding" HOXD12 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.021783043 0.079147544 3238 homeobox D12 "GO:0000785,GO:0000981,GO:0001501,GO:0005515,GO:0005634,GO:0005667,GO:0006357,GO:0007389,GO:0042733,GO:1990837" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|skeletal system development|protein binding|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|pattern specification process|embryonic digit morphogenesis|sequence-specific double-stranded DNA binding" HOXD13 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.025857642 0.023488096 3239 homeobox D13 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001501,GO:0003677,GO:0003682,GO:0003700,GO:0005654,GO:0006355,GO:0006357,GO:0007275,GO:0009952,GO:0030539,GO:0033574,GO:0042127,GO:0042733,GO:0045944,GO:0048619,GO:0060527,GO:0060571,GO:0060602,GO:0060687,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|skeletal system development|DNA binding|chromatin binding|DNA-binding transcription factor activity|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|anterior/posterior pattern specification|male genitalia development|response to testosterone|regulation of cell population proliferation|embryonic digit morphogenesis|positive regulation of transcription by RNA polymerase II|embryonic hindgut morphogenesis|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|morphogenesis of an epithelial fold|branch elongation of an epithelium|regulation of branching involved in prostate gland morphogenesis|sequence-specific double-stranded DNA binding" HOXD3 157.3213771 168.547049 146.0957053 0.866794798 -0.206237599 0.613666392 1 1.60310929 1.366314275 3232 homeobox D3 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0006351,GO:0006357,GO:0007160,GO:0007219,GO:0009952,GO:0010628,GO:0016235,GO:0016604,GO:0021615,GO:0030878,GO:0045666,GO:0045944,GO:0048704,GO:0051216,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|cell-matrix adhesion|Notch signaling pathway|anterior/posterior pattern specification|positive regulation of gene expression|aggresome|nuclear body|glossopharyngeal nerve morphogenesis|thyroid gland development|positive regulation of neuron differentiation|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|cartilage development|sequence-specific double-stranded DNA binding" HOXD4 898.3934706 812.5632423 984.2236989 1.211257964 0.276506152 0.265993227 1 8.430211278 10.04029061 3233 homeobox D4 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007275,GO:0009952,GO:0030054,GO:0045944,GO:0048704,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|multicellular organism development|anterior/posterior pattern specification|cell junction|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|sequence-specific double-stranded DNA binding" HOXD8 209.0105627 200.7998793 217.2212461 1.081779764 0.113406815 0.761916544 1 6.710282095 7.137577053 3234 homeobox D8 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0008595,GO:0045944,GO:0048705,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|anterior/posterior axis specification, embryo|positive regulation of transcription by RNA polymerase II|skeletal system morphogenesis|sequence-specific double-stranded DNA binding" HOXD9 182.7769187 206.0019488 159.5518887 0.774516405 -0.368632299 0.329304632 1 5.87597295 4.474881995 3235 homeobox D9 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005634,GO:0005654,GO:0005730,GO:0006351,GO:0006357,GO:0007338,GO:0007519,GO:0008344,GO:0009952,GO:0009954,GO:0030879,GO:0035115,GO:0035137,GO:0045944,GO:0048704,GO:0048935,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|nucleolus|transcription, DNA-templated|regulation of transcription by RNA polymerase II|single fertilization|skeletal muscle tissue development|adult locomotory behavior|anterior/posterior pattern specification|proximal/distal pattern formation|mammary gland development|embryonic forelimb morphogenesis|hindlimb morphogenesis|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|peripheral nervous system neuron development|sequence-specific double-stranded DNA binding" HP1BP3 4369.827663 4641.28633 4098.368996 0.883024383 -0.17947482 0.452461537 1 30.05301154 26.09347214 50809 heterochromatin protein 1 binding protein 3 "GO:0000786,GO:0003677,GO:0005515,GO:0005634,GO:0005694,GO:0006334,GO:0006355,GO:0016607,GO:0031491,GO:0042127,GO:0070828,GO:0071456,GO:0097298" "nucleosome|DNA binding|protein binding|nucleus|chromosome|nucleosome assembly|regulation of transcription, DNA-templated|nuclear speck|nucleosome binding|regulation of cell population proliferation|heterochromatin organization|cellular response to hypoxia|regulation of nucleus size" HPCAL1 3513.718066 3349.092288 3678.343844 1.098310685 0.135286214 0.569146661 1 33.55263752 36.23456501 3241 hippocalcin like 1 "GO:0005509,GO:0005515,GO:0016020" calcium ion binding|protein binding|membrane HPCAL4 2.962725795 2.080827765 3.844623824 1.847641543 0.88568489 0.829811711 1 0.023507611 0.042706835 51440 hippocalcin like 4 "GO:0005246,GO:0005509,GO:0005515,GO:0007165,GO:0007417,GO:0008022,GO:0019904" calcium channel regulator activity|calcium ion binding|protein binding|signal transduction|central nervous system development|protein C-terminus binding|protein domain specific binding HPF1 482.2349065 459.8629361 504.6068769 1.097298428 0.133955943 0.631540698 1 20.18259844 21.77574465 54969 histone PARylation factor 1 "GO:0005515,GO:0005634,GO:0006974,GO:0008270,GO:0010835,GO:0018312,GO:0042393,GO:0072572" protein binding|nucleus|cellular response to DNA damage stimulus|zinc ion binding|regulation of protein ADP-ribosylation|peptidyl-serine ADP-ribosylation|histone binding|poly-ADP-D-ribose binding HPGD 7.005494435 7.282897178 6.728091692 0.923820772 -0.11431511 1 1 0.089763242 0.081537507 3248 15-hydroxyprostaglandin dehydrogenase "GO:0001822,GO:0004957,GO:0005654,GO:0005737,GO:0005829,GO:0006693,GO:0007179,GO:0007565,GO:0007567,GO:0016323,GO:0016404,GO:0016616,GO:0019372,GO:0030728,GO:0032355,GO:0032496,GO:0042759,GO:0042802,GO:0043065,GO:0045471,GO:0045786,GO:0051287,GO:0055114,GO:0070062,GO:0070403,GO:0070493,GO:0097070,GO:1904707,GO:1905828,GO:2001301" "kidney development|prostaglandin E receptor activity|nucleoplasm|cytoplasm|cytosol|prostaglandin metabolic process|transforming growth factor beta receptor signaling pathway|female pregnancy|parturition|basolateral plasma membrane|15-hydroxyprostaglandin dehydrogenase (NAD+) activity|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|lipoxygenase pathway|ovulation|response to estradiol|response to lipopolysaccharide|long-chain fatty acid biosynthetic process|identical protein binding|positive regulation of apoptotic process|response to ethanol|negative regulation of cell cycle|NAD binding|oxidation-reduction process|extracellular exosome|NAD+ binding|thrombin-activated receptor signaling pathway|ductus arteriosus closure|positive regulation of vascular associated smooth muscle cell proliferation|regulation of prostaglandin catabolic process|lipoxin biosynthetic process" hsa05202 Transcriptional misregulation in cancer HPRT1 2290.962684 1969.50348 2612.421888 1.326436797 0.407555935 0.084820313 1 75.34679636 98.27035647 3251 hypoxanthine phosphoribosyltransferase 1 "GO:0000166,GO:0000287,GO:0001913,GO:0001975,GO:0004422,GO:0005515,GO:0005737,GO:0005829,GO:0006164,GO:0006166,GO:0006168,GO:0006178,GO:0007625,GO:0007626,GO:0021756,GO:0021895,GO:0021954,GO:0032263,GO:0032264,GO:0042417,GO:0042802,GO:0043101,GO:0043103,GO:0045964,GO:0046038,GO:0046040,GO:0046100,GO:0046651,GO:0048813,GO:0051289,GO:0052657,GO:0070062" nucleotide binding|magnesium ion binding|T cell mediated cytotoxicity|response to amphetamine|hypoxanthine phosphoribosyltransferase activity|protein binding|cytoplasm|cytosol|purine nucleotide biosynthetic process|purine ribonucleoside salvage|adenine salvage|guanine salvage|grooming behavior|locomotory behavior|striatum development|cerebral cortex neuron differentiation|central nervous system neuron development|GMP salvage|IMP salvage|dopamine metabolic process|identical protein binding|purine-containing compound salvage|hypoxanthine salvage|positive regulation of dopamine metabolic process|GMP catabolic process|IMP metabolic process|hypoxanthine metabolic process|lymphocyte proliferation|dendrite morphogenesis|protein homotetramerization|guanine phosphoribosyltransferase activity|extracellular exosome "hsa00230,hsa00983" Purine metabolism|Drug metabolism - other enzymes HPS1 1518.022146 1599.116138 1436.928154 0.898576483 -0.154286791 0.518666978 1 19.84695098 17.53557551 3257 HPS1 biogenesis of lysosomal organelles complex 3 subunit 1 "GO:0005085,GO:0005515,GO:0005737,GO:0005764,GO:0005829,GO:0007040,GO:0007601,GO:0016192,GO:0031085,GO:0031410,GO:0046983,GO:0050790,GO:0050896,GO:1903232" guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|lysosome|cytosol|lysosome organization|visual perception|vesicle-mediated transport|BLOC-3 complex|cytoplasmic vesicle|protein dimerization activity|regulation of catalytic activity|response to stimulus|melanosome assembly HPS3 2346.854498 2604.155948 2089.553048 0.802391673 -0.317621461 0.179033454 1 26.84547358 21.18013195 84343 HPS3 biogenesis of lysosomal organelles complex 2 subunit 1 "GO:0005515,GO:0005737,GO:0006996,GO:0031084,GO:0043473" protein binding|cytoplasm|organelle organization|BLOC-2 complex|pigmentation HPS4 1227.84924 1260.981626 1194.716853 0.947449851 -0.077878512 0.749809602 1 8.203861 7.642680488 89781 HPS4 biogenesis of lysosomal organelles complex 3 subunit 2 "GO:0005085,GO:0005515,GO:0005737,GO:0005764,GO:0005765,GO:0005829,GO:0006605,GO:0007040,GO:0007596,GO:0007599,GO:0016020,GO:0016192,GO:0030318,GO:0031085,GO:0031267,GO:0031410,GO:0042470,GO:0042803,GO:0042827,GO:0046983,GO:0048075,GO:0050790,GO:0050821,GO:1903232,GO:1903955" guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|lysosome|lysosomal membrane|cytosol|protein targeting|lysosome organization|blood coagulation|hemostasis|membrane|vesicle-mediated transport|melanocyte differentiation|BLOC-3 complex|small GTPase binding|cytoplasmic vesicle|melanosome|protein homodimerization activity|platelet dense granule|protein dimerization activity|positive regulation of eye pigmentation|regulation of catalytic activity|protein stabilization|melanosome assembly|positive regulation of protein targeting to mitochondrion HPS5 835.3824209 949.8978749 720.866967 0.758888914 -0.398039375 0.11171021 1 9.496872189 7.086470452 11234 HPS5 biogenesis of lysosomal organelles complex 2 subunit 2 "GO:0005515,GO:0005829,GO:0006996,GO:0007596,GO:0031084,GO:0043473" protein binding|cytosol|organelle organization|blood coagulation|BLOC-2 complex|pigmentation HPS6 901.1033314 845.8564866 956.3501762 1.130629358 0.177126063 0.477165662 1 16.79382666 18.66986179 79803 HPS6 biogenesis of lysosomal organelles complex 2 subunit 3 "GO:0005515,GO:0005765,GO:0005783,GO:0006996,GO:0007596,GO:0016020,GO:0030318,GO:0030742,GO:0031084,GO:0031267,GO:0031901,GO:0032418,GO:0072657" protein binding|lysosomal membrane|endoplasmic reticulum|organelle organization|blood coagulation|membrane|melanocyte differentiation|GTP-dependent protein binding|BLOC-2 complex|small GTPase binding|early endosome membrane|lysosome localization|protein localization to membrane HPSE 114.3769444 100.9201466 127.8337421 1.266682089 0.341054483 0.45150732 1 1.157764992 1.441979949 10855 heparanase "GO:0004566,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005764,GO:0005765,GO:0006027,GO:0006029,GO:0007160,GO:0010575,GO:0030194,GO:0030200,GO:0030305,GO:0031012,GO:0033690,GO:0035580,GO:0043202,GO:0043231,GO:0043312,GO:0045121,GO:0045545,GO:0051797,GO:0051798,GO:0051897,GO:0060055,GO:0061042" beta-glucuronidase activity|protein binding|extracellular region|nucleus|nucleoplasm|lysosome|lysosomal membrane|glycosaminoglycan catabolic process|proteoglycan metabolic process|cell-matrix adhesion|positive regulation of vascular endothelial growth factor production|positive regulation of blood coagulation|heparan sulfate proteoglycan catabolic process|heparanase activity|extracellular matrix|positive regulation of osteoblast proliferation|specific granule lumen|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|membrane raft|syndecan binding|regulation of hair follicle development|positive regulation of hair follicle development|positive regulation of protein kinase B signaling|angiogenesis involved in wound healing|vascular wound healing "hsa00531,hsa05205" Glycosaminoglycan degradation|Proteoglycans in cancer HPSE2 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.030313909 0 60495 heparanase 2 (inactive) "GO:0005886,GO:0006027,GO:0008150,GO:0008284,GO:0030198,GO:0030305,GO:0031012,GO:0043395" plasma membrane|glycosaminoglycan catabolic process|biological_process|positive regulation of cell population proliferation|extracellular matrix organization|heparanase activity|extracellular matrix|heparan sulfate proteoglycan binding "hsa00531,hsa05205" Glycosaminoglycan degradation|Proteoglycans in cancer HPX 6.926236509 5.202069413 8.650403604 1.662877389 0.733681797 0.660649523 1 0.176269767 0.288210128 3263 hemopexin "GO:0002639,GO:0002925,GO:0005515,GO:0005576,GO:0005615,GO:0006879,GO:0006898,GO:0015232,GO:0015886,GO:0016032,GO:0020027,GO:0042168,GO:0042531,GO:0046872,GO:0060335,GO:0062023,GO:0070062,GO:0071682,GO:0072562" positive regulation of immunoglobulin production|positive regulation of humoral immune response mediated by circulating immunoglobulin|protein binding|extracellular region|extracellular space|cellular iron ion homeostasis|receptor-mediated endocytosis|heme transmembrane transporter activity|heme transport|viral process|hemoglobin metabolic process|heme metabolic process|positive regulation of tyrosine phosphorylation of STAT protein|metal ion binding|positive regulation of interferon-gamma-mediated signaling pathway|collagen-containing extracellular matrix|extracellular exosome|endocytic vesicle lumen|blood microparticle HR 22.45821724 21.84869154 23.06774294 1.055795168 0.078329968 0.985507105 1 0.221257023 0.229693081 55806 HR lysine demethylase and nuclear receptor corepressor "GO:0000118,GO:0000785,GO:0003712,GO:0005515,GO:0005654,GO:0006357,GO:0016491,GO:0031490,GO:0032454,GO:0033169,GO:0046872,GO:0055114" histone deacetylase complex|chromatin|transcription coregulator activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|oxidoreductase activity|chromatin DNA binding|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|metal ion binding|oxidation-reduction process HRAS 1649.196011 1459.700677 1838.691344 1.259635878 0.333006755 0.161313816 1 61.8266209 76.57582978 3265 "HRas proto-oncogene, GTPase" "GO:0000139,GO:0000165,GO:0001889,GO:0001934,GO:0002223,GO:0003924,GO:0005515,GO:0005525,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0006897,GO:0006935,GO:0007050,GO:0007165,GO:0007166,GO:0007265,GO:0008022,GO:0008284,GO:0008285,GO:0009887,GO:0010629,GO:0010863,GO:0019003,GO:0030335,GO:0032729,GO:0034260,GO:0035900,GO:0042088,GO:0042832,GO:0043406,GO:0043410,GO:0043524,GO:0043547,GO:0044877,GO:0045740,GO:0045944,GO:0046330,GO:0046579,GO:0048013,GO:0048169,GO:0048471,GO:0050679,GO:0050852,GO:0070374,GO:0071480,GO:0090303,GO:0090314,GO:0090398,GO:0097193,GO:0098696,GO:0098978,GO:1900029,GO:2000251,GO:2000630" Golgi membrane|MAPK cascade|liver development|positive regulation of protein phosphorylation|stimulatory C-type lectin receptor signaling pathway|GTPase activity|protein binding|GTP binding|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|plasma membrane|endocytosis|chemotaxis|cell cycle arrest|signal transduction|cell surface receptor signaling pathway|Ras protein signal transduction|protein C-terminus binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|animal organ morphogenesis|negative regulation of gene expression|positive regulation of phospholipase C activity|GDP binding|positive regulation of cell migration|positive regulation of interferon-gamma production|negative regulation of GTPase activity|response to isolation stress|T-helper 1 type immune response|defense response to protozoan|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|negative regulation of neuron apoptotic process|positive regulation of GTPase activity|protein-containing complex binding|positive regulation of DNA replication|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|positive regulation of Ras protein signal transduction|ephrin receptor signaling pathway|regulation of long-term neuronal synaptic plasticity|perinuclear region of cytoplasm|positive regulation of epithelial cell proliferation|T cell receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade|cellular response to gamma radiation|positive regulation of wound healing|positive regulation of protein targeting to membrane|cellular senescence|intrinsic apoptotic signaling pathway|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane|glutamatergic synapse|positive regulation of ruffle assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of miRNA metabolic process "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04062,hsa04068,hsa04071,hsa04072,hsa04137,hsa04140,hsa04144,hsa04150,hsa04151,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04371,hsa04510,hsa04540,hsa04550,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04714,hsa04720,hsa04722,hsa04725,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04929,hsa04933,hsa04935,hsa05010,hsa05022,hsa05034,hsa05132,hsa05160,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05170,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Mitophagy - animal|Autophagy - animal|Endocytosis|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Apelin signaling pathway|Focal adhesion|Gap junction|Signaling pathways regulating pluripotency of stem cells|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|GnRH secretion|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|Salmonella infection|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" HRCT1 18.05375751 19.76786377 16.33965125 0.82657648 -0.274779782 0.809952665 1 1.128315035 0.917032225 646962 histidine rich carboxyl terminus 1 GO:0016021 integral component of membrane HRH1 528.9692429 563.9043244 494.0341614 0.876095713 -0.190839602 0.481889173 1 6.389498382 5.504140338 3269 histamine receptor H1 "GO:0004930,GO:0004969,GO:0004993,GO:0005829,GO:0005886,GO:0005887,GO:0006954,GO:0007186,GO:0007187,GO:0007200,GO:0007268,GO:0007613,GO:0008542,GO:0030425,GO:0030594,GO:0032962,GO:0043114,GO:0045202,GO:0045907,GO:0048016,GO:0048167,GO:0048245,GO:0071420,GO:0098664" "G protein-coupled receptor activity|histamine receptor activity|G protein-coupled serotonin receptor activity|cytosol|plasma membrane|integral component of plasma membrane|inflammatory response|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|phospholipase C-activating G protein-coupled receptor signaling pathway|chemical synaptic transmission|memory|visual learning|dendrite|neurotransmitter receptor activity|positive regulation of inositol trisphosphate biosynthetic process|regulation of vascular permeability|synapse|positive regulation of vasoconstriction|inositol phosphate-mediated signaling|regulation of synaptic plasticity|eosinophil chemotaxis|cellular response to histamine|G protein-coupled serotonin receptor signaling pathway" "hsa04020,hsa04080,hsa04750" Calcium signaling pathway|Neuroactive ligand-receptor interaction|Inflammatory mediator regulation of TRP channels HRK 35.71122539 29.13158871 42.29086206 1.451718356 0.537761587 0.441859173 1 0.255581021 0.364822947 8739 "harakiri, BCL2 interacting protein" "GO:0005515,GO:0005739,GO:0006915,GO:0016021,GO:0031334,GO:0043065,GO:0090200" protein binding|mitochondrion|apoptotic process|integral component of membrane|positive regulation of protein-containing complex assembly|positive regulation of apoptotic process|positive regulation of release of cytochrome c from mitochondria hsa04210 Apoptosis HROB 284.2178867 307.9625093 260.4732641 0.845795369 -0.241619434 0.455460878 1 4.885669771 4.063128808 78995 homologous recombination factor with OB-fold "GO:0000725,GO:0000731,GO:0003697,GO:0005515,GO:0005634,GO:0006974,GO:0007292,GO:0036297,GO:0048232,GO:0090734" recombinational repair|DNA synthesis involved in DNA repair|single-stranded DNA binding|protein binding|nucleus|cellular response to DNA damage stimulus|female gamete generation|interstrand cross-link repair|male gamete generation|site of DNA damage HS1BP3 897.5896018 1018.565191 776.6140124 0.762458819 -0.391268677 0.115098745 1 6.680466045 5.008346082 64342 HCLS1 binding protein 3 "GO:0005515,GO:0005739,GO:0005783,GO:0035091,GO:0042981" protein binding|mitochondrion|endoplasmic reticulum|phosphatidylinositol binding|regulation of apoptotic process HS2ST1 1118.689456 1133.010718 1104.368193 0.974719988 -0.036940266 0.882985277 1 8.318434399 7.972465462 9653 heparan sulfate 2-O-sulfotransferase 1 "GO:0000139,GO:0004394,GO:0006024,GO:0008146,GO:0015014,GO:0015015,GO:0016020,GO:0016021" "Golgi membrane|heparan sulfate 2-O-sulfotransferase activity|glycosaminoglycan biosynthetic process|sulfotransferase activity|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparan sulfate proteoglycan biosynthetic process, enzymatic modification|membrane|integral component of membrane" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS3ST1 90.11530212 82.19269673 98.03790751 1.19278125 0.254329484 0.613370864 1 0.36150265 0.423978142 9957 heparan sulfate-glucosamine 3-sulfotransferase 1 "GO:0005796,GO:0006024,GO:0008146,GO:0008467" Golgi lumen|glycosaminoglycan biosynthetic process|sulfotransferase activity|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS3ST3A1 4.483717655 4.161655531 4.80577978 1.154775965 0.207612985 1 1 0.018539224 0.021050406 9955 heparan sulfate-glucosamine 3-sulfotransferase 3A1 "GO:0000139,GO:0006024,GO:0008146,GO:0008467,GO:0016021,GO:0033872" Golgi membrane|glycosaminoglycan biosynthetic process|sulfotransferase activity|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|integral component of membrane|[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS3ST5 24.61830293 28.09117483 21.14543103 0.752742851 -0.409770993 0.63048508 1 0.192054109 0.142148218 222537 heparan sulfate-glucosamine 3-sulfotransferase 5 "GO:0000139,GO:0005515,GO:0006024,GO:0006477,GO:0008467,GO:0015015,GO:0016021,GO:0046596,GO:0050656,GO:0050819" "Golgi membrane|protein binding|glycosaminoglycan biosynthetic process|protein sulfation|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|heparan sulfate proteoglycan biosynthetic process, enzymatic modification|integral component of membrane|regulation of viral entry into host cell|3'-phosphoadenosine 5'-phosphosulfate binding|negative regulation of coagulation" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS6ST1 309.5992007 330.8516147 288.3467868 0.87152903 -0.198379375 0.528791742 1 4.181137247 3.583005377 9394 heparan sulfate 6-O-sulfotransferase 1 "GO:0000139,GO:0005515,GO:0005887,GO:0006024,GO:0008146,GO:0015015,GO:0017095,GO:0048666" "Golgi membrane|protein binding|integral component of plasma membrane|glycosaminoglycan biosynthetic process|sulfotransferase activity|heparan sulfate proteoglycan biosynthetic process, enzymatic modification|heparan sulfate 6-O-sulfotransferase activity|neuron development" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS6ST3 47.92381966 34.33365813 61.51398118 1.791652406 0.841290771 0.169189072 1 0.081425776 0.143445471 266722 heparan sulfate 6-O-sulfotransferase 3 "GO:0015015,GO:0016021,GO:0017095" "heparan sulfate proteoglycan biosynthetic process, enzymatic modification|integral component of membrane|heparan sulfate 6-O-sulfotransferase activity" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin HSBP1 2337.761187 2113.080596 2562.441779 1.212656907 0.278171431 0.239341687 1 13.03864351 15.54681872 3281 heat shock factor binding protein 1 "GO:0000122,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005856,GO:0006936,GO:0035987,GO:0042802,GO:0070370,GO:1900034" negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytosol|cytoskeleton|muscle contraction|endodermal cell differentiation|identical protein binding|cellular heat acclimation|regulation of cellular response to heat HSBP1L1 303.535355 272.5884373 334.4822727 1.227059651 0.295205384 0.348478945 1 21.11399695 25.4745962 440498 heat shock factor binding protein 1 like 1 "GO:0003714,GO:0005515,GO:0005634,GO:0005829,GO:0045892,GO:0070370" "transcription corepressor activity|protein binding|nucleus|cytosol|negative regulation of transcription, DNA-templated|cellular heat acclimation" HSCB 181.1867298 176.87036 185.5030995 1.048808288 0.068750991 0.869733941 1 7.426629459 7.658770311 150274 HscB mitochondrial iron-sulfur cluster cochaperone "GO:0001671,GO:0003674,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0016226,GO:0032781,GO:0042802,GO:0044571,GO:0046872,GO:0051087,GO:0051259,GO:0097428" ATPase activator activity|molecular_function|protein binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|iron-sulfur cluster assembly|positive regulation of ATPase activity|identical protein binding|[2Fe-2S] cluster assembly|metal ion binding|chaperone binding|protein complex oligomerization|protein maturation by iron-sulfur cluster transfer HSD11B1 3.601819626 6.242483296 0.961155956 0.153970129 -2.699277611 0.237188726 1 0.22344055 0.03382748 3290 hydroxysteroid 11-beta dehydrogenase 1 "GO:0003845,GO:0005496,GO:0005789,GO:0006704,GO:0006706,GO:0016020,GO:0030176,GO:0030324,GO:0042803,GO:0050661,GO:0055114,GO:0070524" 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity|steroid binding|endoplasmic reticulum membrane|glucocorticoid biosynthetic process|steroid catabolic process|membrane|integral component of endoplasmic reticulum membrane|lung development|protein homodimerization activity|NADP binding|oxidation-reduction process|11-beta-hydroxysteroid dehydrogenase (NADP+) activity "hsa00140,hsa00980,hsa05204" Steroid hormone biosynthesis|Metabolism of xenobiotics by cytochrome P450|Chemical carcinogenesis HSD11B1L 36.1521744 28.09117483 44.21317398 1.57391687 0.654359344 0.341452315 1 0.806441297 1.248032022 374875 hydroxysteroid 11-beta dehydrogenase 1 like "GO:0005576,GO:0005654,GO:0016491,GO:0043231,GO:0055114" extracellular region|nucleoplasm|oxidoreductase activity|intracellular membrane-bounded organelle|oxidation-reduction process "hsa00140,hsa00980,hsa05204" Steroid hormone biosynthesis|Metabolism of xenobiotics by cytochrome P450|Chemical carcinogenesis HSD17B1 22.4978462 22.88910542 22.10658699 0.965812625 -0.050184772 1 1 0.956577516 0.908414851 3292 hydroxysteroid 17-beta dehydrogenase 1 "GO:0003824,GO:0004303,GO:0005496,GO:0005515,GO:0005737,GO:0005829,GO:0006694,GO:0006703,GO:0008210,GO:0030283,GO:0035410,GO:0042803,GO:0050661,GO:0055114,GO:0061370,GO:0070401,GO:0072582,GO:1903924" catalytic activity|estradiol 17-beta-dehydrogenase activity|steroid binding|protein binding|cytoplasm|cytosol|steroid biosynthetic process|estrogen biosynthetic process|estrogen metabolic process|testosterone dehydrogenase [NAD(P)] activity|dihydrotestosterone 17-beta-dehydrogenase activity|protein homodimerization activity|NADP binding|oxidation-reduction process|testosterone biosynthetic process|NADP+ binding|17-beta-hydroxysteroid dehydrogenase (NADP+) activity|estradiol binding "hsa00140,hsa04913" Steroid hormone biosynthesis|Ovarian steroidogenesis HSD17B10 952.2226202 900.9984224 1003.446818 1.113705411 0.155367672 0.53103825 1 50.24517224 55.02193349 3028 hydroxysteroid 17-beta dehydrogenase 10 "GO:0000049,GO:0003723,GO:0003857,GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0005886,GO:0006550,GO:0006629,GO:0006635,GO:0006699,GO:0007005,GO:0008207,GO:0008209,GO:0008210,GO:0008709,GO:0009083,GO:0030283,GO:0030678,GO:0042645,GO:0044594,GO:0047015,GO:0047035,GO:0047044,GO:0051289,GO:0062173,GO:0070901,GO:0090646,GO:0097745,GO:0106281,GO:0106282,GO:0106283,GO:1990180" "tRNA binding|RNA binding|3-hydroxyacyl-CoA dehydrogenase activity|protein binding|cytoplasm|mitochondrion|mitochondrial matrix|plasma membrane|isoleucine catabolic process|lipid metabolic process|fatty acid beta-oxidation|bile acid biosynthetic process|mitochondrion organization|C21-steroid hormone metabolic process|androgen metabolic process|estrogen metabolic process|cholate 7-alpha-dehydrogenase activity|branched-chain amino acid catabolic process|testosterone dehydrogenase [NAD(P)] activity|mitochondrial ribonuclease P complex|mitochondrial nucleoid|17-beta-hydroxysteroid dehydrogenase (NAD+) activity|3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity|testosterone dehydrogenase (NAD+) activity|androstan-3-alpha,17-beta-diol dehydrogenase activity|protein homotetramerization|brexanolone metabolic process|mitochondrial tRNA methylation|mitochondrial tRNA processing|mitochondrial tRNA 5'-end processing|chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity|isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity|ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity|mitochondrial tRNA 3'-end processing" "hsa00280,hsa05010,hsa05022" "Valine, leucine and isoleucine degradation|Alzheimer disease|Pathways of neurodegeneration - multiple diseases" HSD17B11 787.2516244 733.4917873 841.0114615 1.146586064 0.19734465 0.435266487 1 20.9668498 23.63801597 51170 hydroxysteroid 17-beta dehydrogenase 11 "GO:0004303,GO:0005515,GO:0005737,GO:0005783,GO:0005811,GO:0005829,GO:0006703,GO:0006710,GO:0016229,GO:0016616,GO:0055114" "estradiol 17-beta-dehydrogenase activity|protein binding|cytoplasm|endoplasmic reticulum|lipid droplet|cytosol|estrogen biosynthetic process|androgen catabolic process|steroid dehydrogenase activity|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|oxidation-reduction process" HSD17B12 2942.959275 2634.327951 3251.590599 1.234315036 0.303710662 0.199498663 1 40.82149856 49.54343812 51144 hydroxysteroid 17-beta dehydrogenase 12 "GO:0001968,GO:0004303,GO:0005515,GO:0005518,GO:0005789,GO:0006633,GO:0006703,GO:0008201,GO:0009923,GO:0010811,GO:0016021,GO:0030198,GO:0031012,GO:0035338,GO:0050062,GO:0055114,GO:0102339,GO:0102340,GO:0102341,GO:0102342" fibronectin binding|estradiol 17-beta-dehydrogenase activity|protein binding|collagen binding|endoplasmic reticulum membrane|fatty acid biosynthetic process|estrogen biosynthetic process|heparin binding|fatty acid elongase complex|positive regulation of cell-substrate adhesion|integral component of membrane|extracellular matrix organization|extracellular matrix|long-chain fatty-acyl-CoA biosynthetic process|long-chain-fatty-acyl-CoA reductase activity|oxidation-reduction process|3-oxo-arachidoyl-CoA reductase activity|3-oxo-behenoyl-CoA reductase activity|3-oxo-lignoceroyl-CoA reductase activity|3-oxo-cerotoyl-CoA reductase activity "hsa00062,hsa00140,hsa01040" Fatty acid elongation|Steroid hormone biosynthesis|Biosynthesis of unsaturated fatty acids HSD17B13 4.003139677 4.161655531 3.844623824 0.923820772 -0.11431511 1 1 0.09379219 0.085197251 345275 hydroxysteroid 17-beta dehydrogenase 13 "GO:0003674,GO:0005515,GO:0005783,GO:0005811,GO:0005829,GO:0016229,GO:0016616,GO:0034389,GO:0046889,GO:0055114" "molecular_function|protein binding|endoplasmic reticulum|lipid droplet|cytosol|steroid dehydrogenase activity|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|lipid droplet organization|positive regulation of lipid biosynthetic process|oxidation-reduction process" HSD17B14 370.9741734 377.6702394 364.2781073 0.964540145 -0.05208681 0.868831735 1 19.12292841 18.13618285 51171 hydroxysteroid 17-beta dehydrogenase 14 "GO:0004303,GO:0005515,GO:0005829,GO:0006703,GO:0006706,GO:0042802,GO:0047045,GO:0055114" estradiol 17-beta-dehydrogenase activity|protein binding|cytosol|estrogen biosynthetic process|steroid catabolic process|identical protein binding|testosterone 17-beta-dehydrogenase (NADP+) activity|oxidation-reduction process HSD17B3 5.965080553 5.202069413 6.728091692 1.29334908 0.371111717 0.919461532 1 0.06914692 0.087934597 3293 hydroxysteroid 17-beta dehydrogenase 3 "GO:0004303,GO:0005783,GO:0005789,GO:0006694,GO:0006702,GO:0030539,GO:0043231,GO:0047045,GO:0055114,GO:0061370" estradiol 17-beta-dehydrogenase activity|endoplasmic reticulum|endoplasmic reticulum membrane|steroid biosynthetic process|androgen biosynthetic process|male genitalia development|intracellular membrane-bounded organelle|testosterone 17-beta-dehydrogenase (NADP+) activity|oxidation-reduction process|testosterone biosynthetic process hsa00140 Steroid hormone biosynthesis HSD17B4 2834.838676 2710.278164 2959.399189 1.091917142 0.126863385 0.592421864 1 51.84321303 55.66122656 3295 hydroxysteroid 17-beta dehydrogenase 4 "GO:0000038,GO:0001649,GO:0003857,GO:0004300,GO:0005777,GO:0005778,GO:0005782,GO:0005829,GO:0006625,GO:0006635,GO:0006699,GO:0008209,GO:0008210,GO:0016020,GO:0016508,GO:0016853,GO:0033540,GO:0033989,GO:0036109,GO:0036111,GO:0036112,GO:0042803,GO:0044594,GO:0060009" "very long-chain fatty acid metabolic process|osteoblast differentiation|3-hydroxyacyl-CoA dehydrogenase activity|enoyl-CoA hydratase activity|peroxisome|peroxisomal membrane|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid beta-oxidation|bile acid biosynthetic process|androgen metabolic process|estrogen metabolic process|membrane|long-chain-enoyl-CoA hydratase activity|isomerase activity|fatty acid beta-oxidation using acyl-CoA oxidase|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|alpha-linolenic acid metabolic process|very long-chain fatty-acyl-CoA metabolic process|medium-chain fatty-acyl-CoA metabolic process|protein homodimerization activity|17-beta-hydroxysteroid dehydrogenase (NAD+) activity|Sertoli cell development" "hsa00120,hsa01040,hsa04146" Primary bile acid biosynthesis|Biosynthesis of unsaturated fatty acids|Peroxisome HSD17B6 24.14275537 15.60620824 32.6793025 2.093993749 1.066257136 0.181996465 1 0.44207784 0.91021776 8630 hydroxysteroid 17-beta dehydrogenase 6 "GO:0003824,GO:0004303,GO:0004745,GO:0005783,GO:0006702,GO:0006710,GO:0009055,GO:0016491,GO:0022900,GO:0031901,GO:0047023,GO:0047024,GO:0047035,GO:0047044,GO:0047045,GO:0062175" "catalytic activity|estradiol 17-beta-dehydrogenase activity|retinol dehydrogenase activity|endoplasmic reticulum|androgen biosynthetic process|androgen catabolic process|electron transfer activity|oxidoreductase activity|electron transport chain|early endosome membrane|androsterone dehydrogenase activity|5alpha-androstane-3beta,17beta-diol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity|androstan-3-alpha,17-beta-diol dehydrogenase activity|testosterone 17-beta-dehydrogenase (NADP+) activity|brexanolone catabolic process" "hsa00140,hsa00830" Steroid hormone biosynthesis|Retinol metabolism HSD17B7 348.7587603 349.5790646 347.9384561 0.995306903 -0.006786646 0.992878318 1 10.63648357 10.40941368 51478 hydroxysteroid 17-beta dehydrogenase 7 "GO:0000253,GO:0004303,GO:0005783,GO:0005789,GO:0006695,GO:0006703,GO:0008209,GO:0016021,GO:0047024,GO:0055114" "3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol biosynthetic process|estrogen biosynthetic process|androgen metabolic process|integral component of membrane|5alpha-androstane-3beta,17beta-diol dehydrogenase activity|oxidation-reduction process" "hsa00100,hsa00140,hsa04913" Steroid biosynthesis|Steroid hormone biosynthesis|Ovarian steroidogenesis HSD17B8 6.004709516 6.242483296 5.766935736 0.923820772 -0.11431511 1 1 0.340992692 0.309744764 7923 hydroxysteroid 17-beta dehydrogenase 8 "GO:0003857,GO:0004303,GO:0005515,GO:0005740,GO:0005759,GO:0005886,GO:0006633,GO:0006703,GO:0008209,GO:0016616,GO:0046949,GO:0047025,GO:0047035,GO:0048038,GO:0051290,GO:0055114,GO:0070404" "3-hydroxyacyl-CoA dehydrogenase activity|estradiol 17-beta-dehydrogenase activity|protein binding|mitochondrial envelope|mitochondrial matrix|plasma membrane|fatty acid biosynthetic process|estrogen biosynthetic process|androgen metabolic process|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|fatty-acyl-CoA biosynthetic process|3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity|testosterone dehydrogenase (NAD+) activity|quinone binding|protein heterotetramerization|oxidation-reduction process|NADH binding" "hsa00061,hsa00140" Fatty acid biosynthesis|Steroid hormone biosynthesis HSD3B7 482.0808067 544.1364606 420.0251528 0.771911429 -0.373492777 0.175406286 1 12.16571547 9.233711572 80270 "hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7" "GO:0003854,GO:0005515,GO:0005789,GO:0005811,GO:0006699,GO:0016021,GO:0016616,GO:0035754,GO:0047016,GO:0055114" "3-beta-hydroxy-delta5-steroid dehydrogenase activity|protein binding|endoplasmic reticulum membrane|lipid droplet|bile acid biosynthetic process|integral component of membrane|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|B cell chemotaxis|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity|oxidation-reduction process" hsa00120 Primary bile acid biosynthesis HSDL1 1171.572541 1183.990998 1159.154083 0.979022716 -0.03058576 0.903200941 1 16.89503302 16.26383622 83693 hydroxysteroid dehydrogenase like 1 "GO:0005515,GO:0005739,GO:0016229,GO:0043231,GO:0045111,GO:0055114" protein binding|mitochondrion|steroid dehydrogenase activity|intracellular membrane-bounded organelle|intermediate filament cytoskeleton|oxidation-reduction process HSDL2 1828.138366 1640.732693 2015.54404 1.228441445 0.296829091 0.210509559 1 26.53420857 32.05027626 84263 hydroxysteroid dehydrogenase like 2 "GO:0003674,GO:0005739,GO:0005777,GO:0008150,GO:0016020,GO:0016491,GO:0055114" molecular_function|mitochondrion|peroxisome|biological_process|membrane|oxidoreductase activity|oxidation-reduction process HSF1 2140.179472 2073.544868 2206.814075 1.064271195 0.089865822 0.705175345 1 48.96516752 51.24018997 3297 heat shock transcription factor 1 "GO:0000122,GO:0000165,GO:0000776,GO:0000777,GO:0000785,GO:0000791,GO:0000792,GO:0000978,GO:0000981,GO:0001162,GO:0001227,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006281,GO:0006357,GO:0006397,GO:0006952,GO:0007584,GO:0008284,GO:0009299,GO:0010667,GO:0014823,GO:0016032,GO:0016605,GO:0019901,GO:0031072,GO:0031333,GO:0031490,GO:0033574,GO:0034605,GO:0034620,GO:0034622,GO:0035865,GO:0042531,GO:0042802,GO:0043280,GO:0043565,GO:0043621,GO:0045931,GO:0045944,GO:0046982,GO:0048471,GO:0051028,GO:0051879,GO:0061408,GO:0061770,GO:0070301,GO:0071222,GO:0071276,GO:0071280,GO:0071392,GO:0071480,GO:0072738,GO:0090084,GO:0090261,GO:0097165,GO:0097431,GO:0097677,GO:0098847,GO:0101031,GO:0120162,GO:1900034,GO:1900365,GO:1901215,GO:1902512,GO:1903936,GO:1904385,GO:1904528,GO:1904843,GO:1904845,GO:1990837,GO:1990841,GO:1990904,GO:1990910,GO:1990911,GO:2001033" "negative regulation of transcription by RNA polymerase II|MAPK cascade|kinetochore|condensed chromosome kinetochore|chromatin|euchromatin|heterochromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|DNA repair|regulation of transcription by RNA polymerase II|mRNA processing|defense response|response to nutrient|positive regulation of cell population proliferation|mRNA transcription|negative regulation of cardiac muscle cell apoptotic process|response to activity|viral process|PML body|protein kinase binding|heat shock protein binding|negative regulation of protein-containing complex assembly|chromatin DNA binding|response to testosterone|cellular response to heat|cellular response to unfolded protein|cellular protein-containing complex assembly|cellular response to potassium ion|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|sequence-specific DNA binding|protein self-association|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|perinuclear region of cytoplasm|mRNA transport|Hsp90 protein binding|positive regulation of transcription from RNA polymerase II promoter in response to heat stress|translation elongation factor binding|cellular response to hydrogen peroxide|cellular response to lipopolysaccharide|cellular response to cadmium ion|cellular response to copper ion|cellular response to estradiol stimulus|cellular response to gamma radiation|cellular response to diamide|negative regulation of inclusion body assembly|positive regulation of inclusion body assembly|nuclear stress granule|mitotic spindle pole|STAT family protein binding|sequence-specific single stranded DNA binding|chaperone complex|positive regulation of cold-induced thermogenesis|regulation of cellular response to heat|positive regulation of mRNA polyadenylation|negative regulation of neuron death|positive regulation of apoptotic DNA fragmentation|cellular response to sodium arsenite|cellular response to angiotensin|positive regulation of microtubule binding|cellular response to nitroglycerin|cellular response to L-glutamine|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding|ribonucleoprotein complex|response to hypobaric hypoxia|response to psychosocial stress|negative regulation of double-strand break repair via nonhomologous end joining" hsa05134 Legionellosis HSF HSF2 635.4594092 558.702255 712.2165634 1.274769445 0.350236344 0.178536263 1 10.33515165 12.95447082 3298 heat shock transcription factor 2 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001162,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007283,GO:0042802,GO:0045944,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|spermatogenesis|identical protein binding|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" HSF HSF2BP 19.85718253 16.64662212 23.06774294 1.385731158 0.470647391 0.614924015 1 0.079074288 0.107742104 11077 heat shock transcription factor 2 binding protein "GO:0005515,GO:0005694,GO:0005829,GO:0006366,GO:0007141,GO:0007283,GO:1990918" protein binding|chromosome|cytosol|transcription by RNA polymerase II|male meiosis I|spermatogenesis|double-strand break repair involved in meiotic recombination HSF4 172.694842 181.0320156 164.3576685 0.907892827 -0.139406091 0.728163392 1 4.316955294 3.853748022 3299 heat shock transcription factor 4 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0006357,GO:0007601,GO:0008284,GO:0016607,GO:0033169,GO:0042802,GO:0043010,GO:0045597,GO:0045944,GO:0048468,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|visual perception|positive regulation of cell population proliferation|nuclear speck|histone H3-K9 demethylation|identical protein binding|camera-type eye development|positive regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|cell development|sequence-specific double-stranded DNA binding" HSH2D 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.020842709 0.075730889 84941 hematopoietic SH2 domain containing "GO:0005515,GO:0005634,GO:0005737,GO:0007165" protein binding|nucleus|cytoplasm|signal transduction HSP90AA1 25200.52939 23404.11029 26996.94849 1.153513129 0.206034425 0.467426503 1 317.3359632 359.9258288 3320 heat shock protein 90 alpha family class A member 1 "GO:0000086,GO:0001934,GO:0002218,GO:0002230,GO:0003723,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006457,GO:0006839,GO:0006898,GO:0006986,GO:0007004,GO:0009408,GO:0009409,GO:0010389,GO:0016020,GO:0016032,GO:0016887,GO:0019221,GO:0021955,GO:0023026,GO:0030010,GO:0030235,GO:0030911,GO:0031396,GO:0031625,GO:0032273,GO:0032728,GO:0032991,GO:0033138,GO:0034605,GO:0034774,GO:0038096,GO:0038128,GO:0042026,GO:0042470,GO:0042802,GO:0042803,GO:0042826,GO:0042981,GO:0043025,GO:0043202,GO:0043209,GO:0043254,GO:0043312,GO:0043335,GO:0044183,GO:0044294,GO:0044295,GO:0045040,GO:0045429,GO:0046677,GO:0048010,GO:0048156,GO:0048471,GO:0048675,GO:0050821,GO:0050999,GO:0051020,GO:0051082,GO:0051131,GO:0051897,GO:0051973,GO:0061684,GO:0070062,GO:0070182,GO:0071682,GO:0097110,GO:0097711,GO:0097718,GO:0098586,GO:1900034,GO:1902949,GO:1903364,GO:1903827,GO:1904813,GO:1905323,GO:1990782" G2/M transition of mitotic cell cycle|positive regulation of protein phosphorylation|activation of innate immune response|positive regulation of defense response to virus by host|RNA binding|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|plasma membrane|protein folding|mitochondrial transport|receptor-mediated endocytosis|response to unfolded protein|telomere maintenance via telomerase|response to heat|response to cold|regulation of G2/M transition of mitotic cell cycle|membrane|viral process|ATPase activity|cytokine-mediated signaling pathway|central nervous system neuron axonogenesis|MHC class II protein complex binding|establishment of cell polarity|nitric-oxide synthase regulator activity|TPR domain binding|regulation of protein ubiquitination|ubiquitin protein ligase binding|positive regulation of protein polymerization|positive regulation of interferon-beta production|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|cellular response to heat|secretory granule lumen|Fc-gamma receptor signaling pathway involved in phagocytosis|ERBB2 signaling pathway|protein refolding|melanosome|identical protein binding|protein homodimerization activity|histone deacetylase binding|regulation of apoptotic process|neuronal cell body|lysosomal lumen|myelin sheath|regulation of protein-containing complex assembly|neutrophil degranulation|protein unfolding|protein folding chaperone|dendritic growth cone|axonal growth cone|protein insertion into mitochondrial outer membrane|positive regulation of nitric oxide biosynthetic process|response to antibiotic|vascular endothelial growth factor receptor signaling pathway|tau protein binding|perinuclear region of cytoplasm|axon extension|protein stabilization|regulation of nitric-oxide synthase activity|GTPase binding|unfolded protein binding|chaperone-mediated protein complex assembly|positive regulation of protein kinase B signaling|positive regulation of telomerase activity|chaperone-mediated autophagy|extracellular exosome|DNA polymerase binding|endocytic vesicle lumen|scaffold protein binding|ciliary basal body-plasma membrane docking|disordered domain specific binding|cellular response to virus|regulation of cellular response to heat|positive regulation of tau-protein kinase activity|positive regulation of cellular protein catabolic process|regulation of cellular protein localization|ficolin-1-rich granule lumen|telomerase holoenzyme complex assembly|protein tyrosine kinase binding "hsa04141,hsa04151,hsa04217,hsa04612,hsa04621,hsa04657,hsa04659,hsa04914,hsa04915,hsa05132,hsa05200,hsa05215,hsa05418" Protein processing in endoplasmic reticulum|PI3K-Akt signaling pathway|Necroptosis|Antigen processing and presentation|NOD-like receptor signaling pathway|IL-17 signaling pathway|Th17 cell differentiation|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Salmonella infection|Pathways in cancer|Prostate cancer|Fluid shear stress and atherosclerosis HSP90AB1 31477.36297 29157.59906 33797.12688 1.159118994 0.213028679 0.472320245 1 544.8485548 620.9762698 3326 heat shock protein 90 alpha family class B member 1 "GO:0001890,GO:0002134,GO:0002135,GO:0003723,GO:0003725,GO:0005515,GO:0005524,GO:0005525,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005765,GO:0005829,GO:0005886,GO:0006457,GO:0006805,GO:0006986,GO:0007004,GO:0008144,GO:0008180,GO:0009651,GO:0016020,GO:0016234,GO:0016323,GO:0016324,GO:0017098,GO:0019062,GO:0019887,GO:0019900,GO:0019901,GO:0021955,GO:0023026,GO:0030010,GO:0030235,GO:0030511,GO:0030911,GO:0031072,GO:0031396,GO:0031526,GO:0031625,GO:0032092,GO:0032435,GO:0032516,GO:0032564,GO:0032991,GO:0033138,GO:0034605,GO:0034751,GO:0034774,GO:0035690,GO:0038096,GO:0042220,GO:0042277,GO:0042307,GO:0042470,GO:0042802,GO:0042803,GO:0042826,GO:0043008,GO:0043025,GO:0043312,GO:0043524,GO:0044183,GO:0044294,GO:0044295,GO:0044325,GO:0045296,GO:0045429,GO:0045597,GO:0045793,GO:0046983,GO:0048156,GO:0048471,GO:0048675,GO:0050821,GO:0051082,GO:0051131,GO:0051248,GO:0051897,GO:0051973,GO:0060334,GO:0060338,GO:0070062,GO:0070182,GO:0071157,GO:0071353,GO:0071407,GO:0071902,GO:0097435,GO:0097718,GO:1900034,GO:1901389,GO:1901799,GO:1902949,GO:1903660,GO:1903827,GO:1904031,GO:1904813,GO:1905323,GO:1990226,GO:1990565,GO:1990913,GO:1990917,GO:2000010" placenta development|UTP binding|CTP binding|RNA binding|double-stranded RNA binding|protein binding|ATP binding|GTP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|lysosomal membrane|cytosol|plasma membrane|protein folding|xenobiotic metabolic process|response to unfolded protein|telomere maintenance via telomerase|drug binding|COP9 signalosome|response to salt stress|membrane|inclusion body|basolateral plasma membrane|apical plasma membrane|sulfonylurea receptor binding|virion attachment to host cell|protein kinase regulator activity|kinase binding|protein kinase binding|central nervous system neuron axonogenesis|MHC class II protein complex binding|establishment of cell polarity|nitric-oxide synthase regulator activity|positive regulation of transforming growth factor beta receptor signaling pathway|TPR domain binding|heat shock protein binding|regulation of protein ubiquitination|brush border membrane|ubiquitin protein ligase binding|positive regulation of protein binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of phosphoprotein phosphatase activity|dATP binding|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|cellular response to heat|aryl hydrocarbon receptor complex|secretory granule lumen|cellular response to drug|Fc-gamma receptor signaling pathway involved in phagocytosis|response to cocaine|peptide binding|positive regulation of protein import into nucleus|melanosome|identical protein binding|protein homodimerization activity|histone deacetylase binding|ATP-dependent protein binding|neuronal cell body|neutrophil degranulation|negative regulation of neuron apoptotic process|protein folding chaperone|dendritic growth cone|axonal growth cone|ion channel binding|cadherin binding|positive regulation of nitric oxide biosynthetic process|positive regulation of cell differentiation|positive regulation of cell size|protein dimerization activity|tau protein binding|perinuclear region of cytoplasm|axon extension|protein stabilization|unfolded protein binding|chaperone-mediated protein complex assembly|negative regulation of protein metabolic process|positive regulation of protein kinase B signaling|positive regulation of telomerase activity|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|extracellular exosome|DNA polymerase binding|negative regulation of cell cycle arrest|cellular response to interleukin-4|cellular response to organic cyclic compound|positive regulation of protein serine/threonine kinase activity|supramolecular fiber organization|disordered domain specific binding|regulation of cellular response to heat|negative regulation of transforming growth factor beta activation|negative regulation of proteasomal protein catabolic process|positive regulation of tau-protein kinase activity|negative regulation of complement-dependent cytotoxicity|regulation of cellular protein localization|positive regulation of cyclin-dependent protein kinase activity|ficolin-1-rich granule lumen|telomerase holoenzyme complex assembly|histone methyltransferase binding|HSP90-CDC37 chaperone complex|sperm head plasma membrane|ooplasm|positive regulation of protein localization to cell surface "hsa04141,hsa04151,hsa04217,hsa04612,hsa04621,hsa04657,hsa04659,hsa04914,hsa04915,hsa05132,hsa05200,hsa05215,hsa05418" Protein processing in endoplasmic reticulum|PI3K-Akt signaling pathway|Necroptosis|Antigen processing and presentation|NOD-like receptor signaling pathway|IL-17 signaling pathway|Th17 cell differentiation|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Salmonella infection|Pathways in cancer|Prostate cancer|Fluid shear stress and atherosclerosis HSP90B1 30980.51504 28288.85347 33672.17661 1.190298385 0.251323275 0.395161741 1 542.6758149 635.1371122 7184 heat shock protein 90 beta family member 1 "GO:0001666,GO:0002224,GO:0003723,GO:0005509,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005783,GO:0005788,GO:0005789,GO:0005829,GO:0005925,GO:0006457,GO:0006898,GO:0015031,GO:0016020,GO:0019221,GO:0019903,GO:0030433,GO:0030496,GO:0030970,GO:0031247,GO:0032991,GO:0033018,GO:0034975,GO:0034976,GO:0036500,GO:0042470,GO:0043066,GO:0043666,GO:0043687,GO:0044267,GO:0048471,GO:0050750,GO:0051082,GO:0051208,GO:0062023,GO:0070062,GO:0071318,GO:0071682" "response to hypoxia|toll-like receptor signaling pathway|RNA binding|calcium ion binding|protein binding|ATP binding|extracellular region|nucleus|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|cytosol|focal adhesion|protein folding|receptor-mediated endocytosis|protein transport|membrane|cytokine-mediated signaling pathway|protein phosphatase binding|ubiquitin-dependent ERAD pathway|midbody|retrograde protein transport, ER to cytosol|actin rod assembly|protein-containing complex|sarcoplasmic reticulum lumen|protein folding in endoplasmic reticulum|response to endoplasmic reticulum stress|ATF6-mediated unfolded protein response|melanosome|negative regulation of apoptotic process|regulation of phosphoprotein phosphatase activity|post-translational protein modification|cellular protein metabolic process|perinuclear region of cytoplasm|low-density lipoprotein particle receptor binding|unfolded protein binding|sequestering of calcium ion|collagen-containing extracellular matrix|extracellular exosome|cellular response to ATP|endocytic vesicle lumen" "hsa04141,hsa04151,hsa04657,hsa04915,hsa04918,hsa05132,hsa05200,hsa05215,hsa05418" Protein processing in endoplasmic reticulum|PI3K-Akt signaling pathway|IL-17 signaling pathway|Estrogen signaling pathway|Thyroid hormone synthesis|Salmonella infection|Pathways in cancer|Prostate cancer|Fluid shear stress and atherosclerosis HSPA12A 68.05337451 70.74814402 65.35860501 0.923820772 -0.11431511 0.856907864 1 0.403602182 0.366616838 259217 heat shock protein family A (Hsp70) member 12A "GO:0003674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0008150,GO:0070062" molecular_function|protein binding|ATP binding|nucleus|cytoplasm|biological_process|extracellular exosome HSPA13 2617.414255 2717.561061 2517.267449 0.926296555 -0.110453947 0.641181647 1 36.76330524 33.48388005 6782 heat shock protein family A (Hsp70) member 13 "GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005783,GO:0016887,GO:0031072,GO:0034620,GO:0042026,GO:0043231,GO:0044183,GO:0051082,GO:0051085,GO:0051787,GO:0070062" protein binding|ATP binding|cytoplasm|mitochondrion|endoplasmic reticulum|ATPase activity|heat shock protein binding|cellular response to unfolded protein|protein refolding|intracellular membrane-bounded organelle|protein folding chaperone|unfolded protein binding|chaperone cofactor-dependent protein refolding|misfolded protein binding|extracellular exosome HSPA14 219.7417941 204.9615349 234.5220533 1.144224712 0.194370408 0.586566159 1 6.207957102 6.984433857 51182 heat shock protein family A (Hsp70) member 14 "GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0016020,GO:0016192,GO:0016887,GO:0031072,GO:0034620,GO:0042026,GO:0044183,GO:0051082,GO:0051083,GO:0051085,GO:0051787" protein binding|ATP binding|nucleus|cytoplasm|cytosol|ribosome|plasma membrane|membrane|vesicle-mediated transport|ATPase activity|heat shock protein binding|cellular response to unfolded protein|protein refolding|protein folding chaperone|unfolded protein binding|'de novo' cotranslational protein folding|chaperone cofactor-dependent protein refolding|misfolded protein binding HSPA1A 305.6407204 315.2454064 296.0360344 0.939065339 -0.090702553 0.78055268 1 7.010028311 6.47271912 3303 heat shock protein family A (Hsp70) member 1A "GO:0001618,GO:0001664,GO:0003714,GO:0003723,GO:0005102,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0005925,GO:0006402,GO:0006986,GO:0007041,GO:0008180,GO:0008285,GO:0010628,GO:0010941,GO:0016192,GO:0016234,GO:0016235,GO:0016607,GO:0016887,GO:0019899,GO:0030308,GO:0030512,GO:0031072,GO:0031249,GO:0031396,GO:0031397,GO:0031625,GO:0031982,GO:0032436,GO:0032757,GO:0032991,GO:0033120,GO:0034599,GO:0034605,GO:0034620,GO:0042026,GO:0042826,GO:0043066,GO:0043312,GO:0043488,GO:0044183,GO:0045296,GO:0045648,GO:0046034,GO:0046718,GO:0047485,GO:0048471,GO:0050821,GO:0051082,GO:0051085,GO:0051092,GO:0051131,GO:0051787,GO:0055131,GO:0060548,GO:0070062,GO:0070370,GO:0070434,GO:0072562,GO:0090063,GO:0090084,GO:0097201,GO:0097718,GO:1900034,GO:1901029,GO:1901673,GO:1902236,GO:1902380,GO:1903265,GO:1904813,GO:1990904,GO:2001240" virus receptor activity|G protein-coupled receptor binding|transcription corepressor activity|RNA binding|signaling receptor binding|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|centrosome|centriole|cytosol|plasma membrane|focal adhesion|mRNA catabolic process|response to unfolded protein|lysosomal transport|COP9 signalosome|negative regulation of cell population proliferation|positive regulation of gene expression|regulation of cell death|vesicle-mediated transport|inclusion body|aggresome|nuclear speck|ATPase activity|enzyme binding|negative regulation of cell growth|negative regulation of transforming growth factor beta receptor signaling pathway|heat shock protein binding|denatured protein binding|regulation of protein ubiquitination|negative regulation of protein ubiquitination|ubiquitin protein ligase binding|vesicle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of interleukin-8 production|protein-containing complex|positive regulation of RNA splicing|cellular response to oxidative stress|cellular response to heat|cellular response to unfolded protein|protein refolding|histone deacetylase binding|negative regulation of apoptotic process|neutrophil degranulation|regulation of mRNA stability|protein folding chaperone|cadherin binding|positive regulation of erythrocyte differentiation|ATP metabolic process|viral entry into host cell|protein N-terminus binding|perinuclear region of cytoplasm|protein stabilization|unfolded protein binding|chaperone cofactor-dependent protein refolding|positive regulation of NF-kappaB transcription factor activity|chaperone-mediated protein complex assembly|misfolded protein binding|C3HC4-type RING finger domain binding|negative regulation of cell death|extracellular exosome|cellular heat acclimation|positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|blood microparticle|positive regulation of microtubule nucleation|negative regulation of inclusion body assembly|negative regulation of transcription from RNA polymerase II promoter in response to stress|disordered domain specific binding|regulation of cellular response to heat|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|regulation of mitotic spindle assembly|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of endoribonuclease activity|positive regulation of tumor necrosis factor-mediated signaling pathway|ficolin-1-rich granule lumen|ribonucleoprotein complex|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa03040,hsa04010,hsa04141,hsa04144,hsa04213,hsa04612,hsa04915,hsa05020,hsa05134,hsa05145,hsa05162" Spliceosome|MAPK signaling pathway|Protein processing in endoplasmic reticulum|Endocytosis|Longevity regulating pathway - multiple species|Antigen processing and presentation|Estrogen signaling pathway|Prion disease|Legionellosis|Toxoplasmosis|Measles HSPA1B 518.9267951 539.9748051 497.8787852 0.92204077 -0.117097551 0.67030052 1 11.44913108 10.37991581 3304 heat shock protein family A (Hsp70) member 1B "GO:0001618,GO:0001664,GO:0003723,GO:0005102,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0005925,GO:0006402,GO:0008180,GO:0008285,GO:0010628,GO:0010941,GO:0016192,GO:0016234,GO:0016235,GO:0016607,GO:0016887,GO:0019899,GO:0030308,GO:0031072,GO:0031396,GO:0031397,GO:0031625,GO:0031982,GO:0032436,GO:0032757,GO:0032991,GO:0034599,GO:0034605,GO:0034620,GO:0042026,GO:0042826,GO:0043066,GO:0043312,GO:0044183,GO:0045648,GO:0046034,GO:0046718,GO:0047485,GO:0048471,GO:0050821,GO:0051082,GO:0051085,GO:0051092,GO:0051787,GO:0055131,GO:0060548,GO:0070062,GO:0070370,GO:0070434,GO:0072562,GO:0090063,GO:0090084,GO:1900034,GO:1901673,GO:1903265,GO:1904813,GO:1990904,GO:2001240" virus receptor activity|G protein-coupled receptor binding|RNA binding|signaling receptor binding|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|centrosome|centriole|cytosol|plasma membrane|focal adhesion|mRNA catabolic process|COP9 signalosome|negative regulation of cell population proliferation|positive regulation of gene expression|regulation of cell death|vesicle-mediated transport|inclusion body|aggresome|nuclear speck|ATPase activity|enzyme binding|negative regulation of cell growth|heat shock protein binding|regulation of protein ubiquitination|negative regulation of protein ubiquitination|ubiquitin protein ligase binding|vesicle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of interleukin-8 production|protein-containing complex|cellular response to oxidative stress|cellular response to heat|cellular response to unfolded protein|protein refolding|histone deacetylase binding|negative regulation of apoptotic process|neutrophil degranulation|protein folding chaperone|positive regulation of erythrocyte differentiation|ATP metabolic process|viral entry into host cell|protein N-terminus binding|perinuclear region of cytoplasm|protein stabilization|unfolded protein binding|chaperone cofactor-dependent protein refolding|positive regulation of NF-kappaB transcription factor activity|misfolded protein binding|C3HC4-type RING finger domain binding|negative regulation of cell death|extracellular exosome|cellular heat acclimation|positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|blood microparticle|positive regulation of microtubule nucleation|negative regulation of inclusion body assembly|regulation of cellular response to heat|regulation of mitotic spindle assembly|positive regulation of tumor necrosis factor-mediated signaling pathway|ficolin-1-rich granule lumen|ribonucleoprotein complex|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa03040,hsa04010,hsa04141,hsa04144,hsa04213,hsa04612,hsa04915,hsa05020,hsa05134,hsa05145,hsa05162" Spliceosome|MAPK signaling pathway|Protein processing in endoplasmic reticulum|Endocytosis|Longevity regulating pathway - multiple species|Antigen processing and presentation|Estrogen signaling pathway|Prion disease|Legionellosis|Toxoplasmosis|Measles HSPA1L 36.46920611 36.41448589 36.52392633 1.003005409 0.004329387 1 1 0.703611218 0.693916492 3305 heat shock protein family A (Hsp70) member 1 like "GO:0002199,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005759,GO:0005829,GO:0005886,GO:0006986,GO:0007339,GO:0008180,GO:0016192,GO:0016887,GO:0031072,GO:0031625,GO:0034620,GO:0042026,GO:0044183,GO:0044297,GO:0051082,GO:0051085,GO:0051787,GO:0072562,GO:1900034,GO:1903955" zona pellucida receptor complex|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrial matrix|cytosol|plasma membrane|response to unfolded protein|binding of sperm to zona pellucida|COP9 signalosome|vesicle-mediated transport|ATPase activity|heat shock protein binding|ubiquitin protein ligase binding|cellular response to unfolded protein|protein refolding|protein folding chaperone|cell body|unfolded protein binding|chaperone cofactor-dependent protein refolding|misfolded protein binding|blood microparticle|regulation of cellular response to heat|positive regulation of protein targeting to mitochondrion "hsa03040,hsa04010,hsa04141,hsa04144,hsa04213,hsa04612,hsa04915,hsa05020,hsa05134,hsa05145,hsa05162" Spliceosome|MAPK signaling pathway|Protein processing in endoplasmic reticulum|Endocytosis|Longevity regulating pathway - multiple species|Antigen processing and presentation|Estrogen signaling pathway|Prion disease|Legionellosis|Toxoplasmosis|Measles HSPA2 42.3946577 40.57614142 44.21317398 1.089634756 0.123844627 0.882393333 1 0.843253151 0.903462433 3306 heat shock protein family A (Hsp70) member 2 "GO:0000795,GO:0001673,GO:0001934,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006986,GO:0007140,GO:0007141,GO:0007283,GO:0007286,GO:0009408,GO:0009409,GO:0009986,GO:0010971,GO:0016020,GO:0016192,GO:0016887,GO:0019899,GO:0031072,GO:0032781,GO:0034620,GO:0036128,GO:0042026,GO:0044183,GO:0048156,GO:0051082,GO:0051085,GO:0051087,GO:0051787,GO:0051861,GO:0070062,GO:0070194,GO:0072562,GO:0072687,GO:0090084,GO:0097718,GO:1901896" synaptonemal complex|male germ cell nucleus|positive regulation of protein phosphorylation|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|response to unfolded protein|male meiotic nuclear division|male meiosis I|spermatogenesis|spermatid development|response to heat|response to cold|cell surface|positive regulation of G2/M transition of mitotic cell cycle|membrane|vesicle-mediated transport|ATPase activity|enzyme binding|heat shock protein binding|positive regulation of ATPase activity|cellular response to unfolded protein|CatSper complex|protein refolding|protein folding chaperone|tau protein binding|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding|misfolded protein binding|glycolipid binding|extracellular exosome|synaptonemal complex disassembly|blood microparticle|meiotic spindle|negative regulation of inclusion body assembly|disordered domain specific binding|positive regulation of ATPase-coupled calcium transmembrane transporter activity "hsa03040,hsa04010,hsa04141,hsa04144,hsa04213,hsa04612,hsa04915,hsa05020,hsa05134,hsa05145,hsa05162" Spliceosome|MAPK signaling pathway|Protein processing in endoplasmic reticulum|Endocytosis|Longevity regulating pathway - multiple species|Antigen processing and presentation|Estrogen signaling pathway|Prion disease|Legionellosis|Toxoplasmosis|Measles HSPA4 4162.84125 3988.946826 4336.735673 1.087188138 0.120601621 0.613394363 1 44.59211578 47.66877187 3308 heat shock protein family A (Hsp70) member 4 "GO:0005515,GO:0005524,GO:0005634,GO:0005739,GO:0005829,GO:0006986,GO:0045040,GO:0051131,GO:0070062" protein binding|ATP binding|nucleus|mitochondrion|cytosol|response to unfolded protein|protein insertion into mitochondrial outer membrane|chaperone-mediated protein complex assembly|extracellular exosome "hsa04530,hsa04612" Tight junction|Antigen processing and presentation HSPA4L 703.8241706 751.1788233 656.4695179 0.873919096 -0.194428369 0.449182498 1 3.288412205 2.825716965 22824 heat shock protein family A (Hsp70) member 4 like "GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006457,GO:0006986" ATP binding|nucleus|cytoplasm|cytosol|protein folding|response to unfolded protein hsa04141 Protein processing in endoplasmic reticulum HSPA5 20637.75622 20535.68922 20739.82322 1.009940451 0.014270229 0.958721752 1 279.5082863 277.5630385 3309 heat shock protein family A (Hsp70) member 5 "GO:0001554,GO:0005509,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005783,GO:0005788,GO:0005789,GO:0005790,GO:0005793,GO:0005829,GO:0005886,GO:0005925,GO:0006983,GO:0008180,GO:0009986,GO:0010976,GO:0016020,GO:0016887,GO:0019899,GO:0019904,GO:0021589,GO:0021680,GO:0021762,GO:0030176,GO:0030182,GO:0030335,GO:0030433,GO:0030496,GO:0030512,GO:0030968,GO:0031072,GO:0031204,GO:0031333,GO:0031398,GO:0031625,GO:0032991,GO:0034620,GO:0034663,GO:0034975,GO:0035437,GO:0035690,GO:0036498,GO:0036499,GO:0036500,GO:0042026,GO:0042149,GO:0042220,GO:0042470,GO:0043022,GO:0043066,GO:0043231,GO:0044183,GO:0045296,GO:0051082,GO:0051085,GO:0051087,GO:0051402,GO:0051787,GO:0060904,GO:0070062,GO:0071236,GO:0071277,GO:0071287,GO:0071320,GO:0071353,GO:0071480,GO:0097501,GO:1901998,GO:1903891,GO:1903894,GO:1903895,GO:1903897,GO:1904313,GO:1990090,GO:1990440" "luteolysis|calcium ion binding|protein binding|ATP binding|nucleus|cytoplasm|mitochondrion|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|smooth endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cytosol|plasma membrane|focal adhesion|ER overload response|COP9 signalosome|cell surface|positive regulation of neuron projection development|membrane|ATPase activity|enzyme binding|protein domain specific binding|cerebellum structural organization|cerebellar Purkinje cell layer development|substantia nigra development|integral component of endoplasmic reticulum membrane|neuron differentiation|positive regulation of cell migration|ubiquitin-dependent ERAD pathway|midbody|negative regulation of transforming growth factor beta receptor signaling pathway|endoplasmic reticulum unfolded protein response|heat shock protein binding|posttranslational protein targeting to membrane, translocation|negative regulation of protein-containing complex assembly|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|protein-containing complex|cellular response to unfolded protein|endoplasmic reticulum chaperone complex|protein folding in endoplasmic reticulum|maintenance of protein localization in endoplasmic reticulum|cellular response to drug|IRE1-mediated unfolded protein response|PERK-mediated unfolded protein response|ATF6-mediated unfolded protein response|protein refolding|cellular response to glucose starvation|response to cocaine|melanosome|ribosome binding|negative regulation of apoptotic process|intracellular membrane-bounded organelle|protein folding chaperone|cadherin binding|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding|neuron apoptotic process|misfolded protein binding|regulation of protein folding in endoplasmic reticulum|extracellular exosome|cellular response to antibiotic|cellular response to calcium ion|cellular response to manganese ion|cellular response to cAMP|cellular response to interleukin-4|cellular response to gamma radiation|stress response to metal ion|toxin transport|regulation of ATF6-mediated unfolded protein response|regulation of IRE1-mediated unfolded protein response|negative regulation of IRE1-mediated unfolded protein response|regulation of PERK-mediated unfolded protein response|response to methamphetamine hydrochloride|cellular response to nerve growth factor stimulus|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" "hsa03060,hsa04141,hsa04612,hsa04918,hsa05012,hsa05014,hsa05020,hsa05022" Protein export|Protein processing in endoplasmic reticulum|Antigen processing and presentation|Thyroid hormone synthesis|Parkinson disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases HSPA6 3.443303773 2.080827765 4.80577978 2.309551929 1.207612985 0.648665767 1 0.04715497 0.107084442 3310 heat shock protein family A (Hsp70) member 6 "GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005814,GO:0005829,GO:0005886,GO:0006986,GO:0008180,GO:0016192,GO:0016887,GO:0019899,GO:0031072,GO:0031625,GO:0034605,GO:0034620,GO:0034774,GO:0042026,GO:0043312,GO:0044183,GO:0051082,GO:0051085,GO:0051787,GO:0070062,GO:0070370,GO:0072562,GO:1904813" protein binding|ATP binding|extracellular region|nucleus|cytoplasm|centriole|cytosol|plasma membrane|response to unfolded protein|COP9 signalosome|vesicle-mediated transport|ATPase activity|enzyme binding|heat shock protein binding|ubiquitin protein ligase binding|cellular response to heat|cellular response to unfolded protein|secretory granule lumen|protein refolding|neutrophil degranulation|protein folding chaperone|unfolded protein binding|chaperone cofactor-dependent protein refolding|misfolded protein binding|extracellular exosome|cellular heat acclimation|blood microparticle|ficolin-1-rich granule lumen "hsa03040,hsa04010,hsa04141,hsa04144,hsa04213,hsa04612,hsa04915,hsa05020,hsa05134,hsa05145,hsa05162" Spliceosome|MAPK signaling pathway|Protein processing in endoplasmic reticulum|Endocytosis|Longevity regulating pathway - multiple species|Antigen processing and presentation|Estrogen signaling pathway|Prion disease|Legionellosis|Toxoplasmosis|Measles HSPA8 28435.1606 26731.35389 30138.96731 1.127476275 0.173097076 0.549984289 1 624.6073672 692.4456528 3312 heat shock protein family A (Hsp70) member 8 "GO:0000398,GO:0000974,GO:0001664,GO:0001786,GO:0003723,GO:0005515,GO:0005524,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005681,GO:0005730,GO:0005737,GO:0005764,GO:0005765,GO:0005770,GO:0005776,GO:0005829,GO:0005886,GO:0005925,GO:0006457,GO:0006986,GO:0007269,GO:0009267,GO:0016020,GO:0016032,GO:0016192,GO:0016887,GO:0019221,GO:0019899,GO:0023026,GO:0030425,GO:0030674,GO:0031072,GO:0031625,GO:0031647,GO:0034620,GO:0034774,GO:0042026,GO:0042470,GO:0043195,GO:0043202,GO:0043254,GO:0043312,GO:0043488,GO:0044183,GO:0044829,GO:0045296,GO:0045892,GO:0046034,GO:0048026,GO:0048471,GO:0051082,GO:0051085,GO:0051087,GO:0051726,GO:0051787,GO:0055131,GO:0061024,GO:0061202,GO:0061635,GO:0061684,GO:0061738,GO:0061740,GO:0061741,GO:0070062,GO:0072318,GO:0072562,GO:0098575,GO:0098684,GO:0098690,GO:0098978,GO:0099175,GO:0099523,GO:0099524,GO:0099634,GO:0101031,GO:1900034,GO:1902904,GO:1904589,GO:1904764,GO:1904813,GO:1990832,GO:1990833,GO:1990904" "mRNA splicing, via spliceosome|Prp19 complex|G protein-coupled receptor binding|phosphatidylserine binding|RNA binding|protein binding|ATP binding|extracellular region|extracellular space|nucleus|nucleoplasm|spliceosomal complex|nucleolus|cytoplasm|lysosome|lysosomal membrane|late endosome|autophagosome|cytosol|plasma membrane|focal adhesion|protein folding|response to unfolded protein|neurotransmitter secretion|cellular response to starvation|membrane|viral process|vesicle-mediated transport|ATPase activity|cytokine-mediated signaling pathway|enzyme binding|MHC class II protein complex binding|dendrite|protein-macromolecule adaptor activity|heat shock protein binding|ubiquitin protein ligase binding|regulation of protein stability|cellular response to unfolded protein|secretory granule lumen|protein refolding|melanosome|terminal bouton|lysosomal lumen|regulation of protein-containing complex assembly|neutrophil degranulation|regulation of mRNA stability|protein folding chaperone|positive regulation by host of viral genome replication|cadherin binding|negative regulation of transcription, DNA-templated|ATP metabolic process|positive regulation of mRNA splicing, via spliceosome|perinuclear region of cytoplasm|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding|regulation of cell cycle|misfolded protein binding|C3HC4-type RING finger domain binding|membrane organization|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|regulation of protein complex stability|chaperone-mediated autophagy|late endosomal microautophagy|protein targeting to lysosome involved in chaperone-mediated autophagy|chaperone-mediated protein transport involved in chaperone-mediated autophagy|extracellular exosome|clathrin coat disassembly|blood microparticle|lumenal side of lysosomal membrane|photoreceptor ribbon synapse|glycinergic synapse|glutamatergic synapse|regulation of postsynapse organization|presynaptic cytosol|postsynaptic cytosol|postsynaptic specialization membrane|chaperone complex|regulation of cellular response to heat|negative regulation of supramolecular fiber organization|regulation of protein import|chaperone-mediated autophagy translocation complex disassembly|ficolin-1-rich granule lumen|slow axonal transport|clathrin-uncoating ATPase activity|ribonucleoprotein complex" "hsa03040,hsa04010,hsa04141,hsa04144,hsa04213,hsa04612,hsa04915,hsa05020,hsa05134,hsa05145,hsa05162" Spliceosome|MAPK signaling pathway|Protein processing in endoplasmic reticulum|Endocytosis|Longevity regulating pathway - multiple species|Antigen processing and presentation|Estrogen signaling pathway|Prion disease|Legionellosis|Toxoplasmosis|Measles HSPA9 8294.481488 8483.534799 8105.428177 0.955430533 -0.065777112 0.790622313 1 102.8044187 96.57886043 3313 heat shock protein family A (Hsp70) member 9 "GO:0001401,GO:0003723,GO:0005515,GO:0005524,GO:0005730,GO:0005737,GO:0005739,GO:0005759,GO:0005925,GO:0006611,GO:0007007,GO:0016226,GO:0016887,GO:0030218,GO:0031072,GO:0031625,GO:0034620,GO:0035722,GO:0042026,GO:0042645,GO:0043066,GO:0044183,GO:0045646,GO:0045647,GO:0051082,GO:0051085,GO:0051787,GO:0070062,GO:0140275,GO:1902037,GO:1903707" SAM complex|RNA binding|protein binding|ATP binding|nucleolus|cytoplasm|mitochondrion|mitochondrial matrix|focal adhesion|protein export from nucleus|inner mitochondrial membrane organization|iron-sulfur cluster assembly|ATPase activity|erythrocyte differentiation|heat shock protein binding|ubiquitin protein ligase binding|cellular response to unfolded protein|interleukin-12-mediated signaling pathway|protein refolding|mitochondrial nucleoid|negative regulation of apoptotic process|protein folding chaperone|regulation of erythrocyte differentiation|negative regulation of erythrocyte differentiation|unfolded protein binding|chaperone cofactor-dependent protein refolding|misfolded protein binding|extracellular exosome|MIB complex|negative regulation of hematopoietic stem cell differentiation|negative regulation of hemopoiesis "hsa03018,hsa05152" RNA degradation|Tuberculosis HSPB1 4325.218699 3735.085839 4915.351559 1.315994269 0.396153207 0.09725108 1 256.5439722 331.9609445 3315 heat shock protein family B (small) member 1 "GO:0000502,GO:0001895,GO:0001932,GO:0003723,GO:0005080,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005819,GO:0005829,GO:0005856,GO:0005925,GO:0006446,GO:0006469,GO:0006986,GO:0008426,GO:0009615,GO:0010506,GO:0016032,GO:0019901,GO:0032731,GO:0032760,GO:0035556,GO:0035924,GO:0038033,GO:0042802,GO:0042803,GO:0043066,GO:0043122,GO:0043130,GO:0043488,GO:0043536,GO:0044183,GO:0045766,GO:0061077,GO:0061629,GO:0070062,GO:0070527,GO:0071901,GO:0099641,GO:1902176,GO:1904115,GO:2001028" proteasome complex|retina homeostasis|regulation of protein phosphorylation|RNA binding|protein kinase C binding|protein binding|extracellular space|nucleus|cytoplasm|spindle|cytosol|cytoskeleton|focal adhesion|regulation of translational initiation|negative regulation of protein kinase activity|response to unfolded protein|protein kinase C inhibitor activity|response to virus|regulation of autophagy|viral process|protein kinase binding|positive regulation of interleukin-1 beta production|positive regulation of tumor necrosis factor production|intracellular signal transduction|cellular response to vascular endothelial growth factor stimulus|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|regulation of mRNA stability|positive regulation of blood vessel endothelial cell migration|protein folding chaperone|positive regulation of angiogenesis|chaperone-mediated protein folding|RNA polymerase II-specific DNA-binding transcription factor binding|extracellular exosome|platelet aggregation|negative regulation of protein serine/threonine kinase activity|anterograde axonal protein transport|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|axon cytoplasm|positive regulation of endothelial cell chemotaxis "hsa04010,hsa04370,hsa05146" MAPK signaling pathway|VEGF signaling pathway|Amoebiasis HSPB11 1128.440638 985.2719469 1271.60933 1.290617615 0.368061621 0.130397091 1 40.51013324 51.4082048 51668 heat shock protein family B (small) member 11 "GO:0001822,GO:0005515,GO:0005813,GO:0005929,GO:0007283,GO:0030154,GO:0030992,GO:0035735,GO:0046872,GO:0060271,GO:0097542" kidney development|protein binding|centrosome|cilium|spermatogenesis|cell differentiation|intraciliary transport particle B|intraciliary transport involved in cilium assembly|metal ion binding|cilium assembly|ciliary tip HSPB6 3.601819626 6.242483296 0.961155956 0.153970129 -2.699277611 0.237188726 1 0.228184836 0.034545734 126393 heat shock protein family B (small) member 6 "GO:0005212,GO:0005515,GO:0005576,GO:0005634,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0006937,GO:0010667,GO:0042803,GO:0045766,GO:0051082,GO:0051087,GO:0061077" structural constituent of eye lens|protein binding|extracellular region|nucleus|nucleolus|cytoplasm|Golgi apparatus|cytosol|regulation of muscle contraction|negative regulation of cardiac muscle cell apoptotic process|protein homodimerization activity|positive regulation of angiogenesis|unfolded protein binding|chaperone binding|chaperone-mediated protein folding HSPB8 7.045123399 8.323311061 5.766935736 0.692865579 -0.529352609 0.780164403 1 0.238688777 0.16261184 26353 heat shock protein family B (small) member 8 "GO:0004672,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0016604,GO:0034620,GO:0042802,GO:0042803,GO:0101031,GO:1900034,GO:1905337" protein kinase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|nuclear body|cellular response to unfolded protein|identical protein binding|protein homodimerization activity|chaperone complex|regulation of cellular response to heat|positive regulation of aggrephagy HSPBAP1 139.4261355 152.9408407 125.9114302 0.823268851 -0.280564453 0.507443043 1 1.713661889 1.387196552 79663 HSPB1 associated protein 1 "GO:0005515,GO:0005737,GO:0016706,GO:0055114" protein binding|cytoplasm|2-oxoglutarate-dependent dioxygenase activity|oxidation-reduction process HSPBP1 346.1973546 345.417409 346.9773001 1.00451596 0.006500486 0.993793884 1 9.198748638 9.085666079 23640 HSPA (Hsp70) binding protein 1 "GO:0000774,GO:0004857,GO:0005515,GO:0005783,GO:0006457,GO:0031398,GO:0031625,GO:0032436,GO:0043086" adenyl-nucleotide exchange factor activity|enzyme inhibitor activity|protein binding|endoplasmic reticulum|protein folding|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of catalytic activity hsa04141 Protein processing in endoplasmic reticulum HSPD1 11563.16073 11594.37231 11531.94916 0.994616082 -0.007788336 0.975985645 1 262.1908223 256.4154215 3329 heat shock protein family D (Hsp60) member 1 "GO:0001530,GO:0002039,GO:0002755,GO:0002842,GO:0003688,GO:0003697,GO:0003723,GO:0003725,GO:0005515,GO:0005524,GO:0005615,GO:0005737,GO:0005739,GO:0005743,GO:0005759,GO:0005769,GO:0005829,GO:0005886,GO:0005905,GO:0006357,GO:0006457,GO:0006458,GO:0006919,GO:0006986,GO:0008035,GO:0008637,GO:0009409,GO:0009986,GO:0016020,GO:0016032,GO:0016853,GO:0016887,GO:0019899,GO:0030135,GO:0030141,GO:0031625,GO:0032727,GO:0032729,GO:0032733,GO:0032735,GO:0032755,GO:0032991,GO:0034185,GO:0034186,GO:0034514,GO:0042026,GO:0042100,GO:0042110,GO:0042113,GO:0043032,GO:0043065,GO:0043066,GO:0044406,GO:0045041,GO:0046696,GO:0048291,GO:0050821,GO:0050870,GO:0051082,GO:0051087,GO:0051131,GO:0051604,GO:0051702,GO:0070062" lipopolysaccharide binding|p53 binding|MyD88-dependent toll-like receptor signaling pathway|positive regulation of T cell mediated immune response to tumor cell|DNA replication origin binding|single-stranded DNA binding|RNA binding|double-stranded RNA binding|protein binding|ATP binding|extracellular space|cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|early endosome|cytosol|plasma membrane|clathrin-coated pit|regulation of transcription by RNA polymerase II|protein folding|'de novo' protein folding|activation of cysteine-type endopeptidase activity involved in apoptotic process|response to unfolded protein|high-density lipoprotein particle binding|apoptotic mitochondrial changes|response to cold|cell surface|membrane|viral process|isomerase activity|ATPase activity|enzyme binding|coated vesicle|secretory granule|ubiquitin protein ligase binding|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|protein-containing complex|apolipoprotein binding|apolipoprotein A-I binding|mitochondrial unfolded protein response|protein refolding|B cell proliferation|T cell activation|B cell activation|positive regulation of macrophage activation|positive regulation of apoptotic process|negative regulation of apoptotic process|adhesion of symbiont to host|protein import into mitochondrial intermembrane space|lipopolysaccharide receptor complex|isotype switching to IgG isotypes|protein stabilization|positive regulation of T cell activation|unfolded protein binding|chaperone binding|chaperone-mediated protein complex assembly|protein maturation|biological process involved in interaction with symbiont|extracellular exosome "hsa03018,hsa04940,hsa05134,hsa05152" RNA degradation|Type I diabetes mellitus|Legionellosis|Tuberculosis HSPE1 133.9170952 109.2434577 158.5907327 1.451718356 0.537761587 0.204409182 1 10.46700638 14.94087512 3336 heat shock protein family E (Hsp10) member 1 "GO:0001649,GO:0003723,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0006457,GO:0006919,GO:0006986,GO:0016020,GO:0046872,GO:0051082,GO:0051085,GO:0051087,GO:0070062" osteoblast differentiation|RNA binding|protein binding|ATP binding|mitochondrion|mitochondrial matrix|protein folding|activation of cysteine-type endopeptidase activity involved in apoptotic process|response to unfolded protein|membrane|metal ion binding|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding|extracellular exosome HSPG2 580.504943 579.5105326 581.4993534 1.003431897 0.004942705 0.992559597 1 2.057575147 2.030087637 3339 heparan sulfate proteoglycan 2 "GO:0001523,GO:0001525,GO:0001540,GO:0005509,GO:0005515,GO:0005576,GO:0005604,GO:0005615,GO:0005796,GO:0005886,GO:0005925,GO:0006024,GO:0006027,GO:0006629,GO:0006898,GO:0006954,GO:0007420,GO:0008022,GO:0009887,GO:0009888,GO:0016525,GO:0030021,GO:0030154,GO:0030198,GO:0043202,GO:0044267,GO:0050750,GO:0062023,GO:0070062,GO:0072359,GO:0098797" retinoid metabolic process|angiogenesis|amyloid-beta binding|calcium ion binding|protein binding|extracellular region|basement membrane|extracellular space|Golgi lumen|plasma membrane|focal adhesion|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|lipid metabolic process|receptor-mediated endocytosis|inflammatory response|brain development|protein C-terminus binding|animal organ morphogenesis|tissue development|negative regulation of angiogenesis|extracellular matrix structural constituent conferring compression resistance|cell differentiation|extracellular matrix organization|lysosomal lumen|cellular protein metabolic process|low-density lipoprotein particle receptor binding|collagen-containing extracellular matrix|extracellular exosome|circulatory system development|plasma membrane protein complex "hsa04512,hsa05161,hsa05205" ECM-receptor interaction|Hepatitis B|Proteoglycans in cancer HSPH1 3784.528845 3734.045425 3835.012264 1.027039532 0.038491713 0.872417301 1 35.10908059 35.45502497 10808 heat shock protein family H (Hsp110) member 1 "GO:0000774,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005874,GO:0006898,GO:0006986,GO:0032991,GO:0043014,GO:0045345,GO:0050790,GO:0051085,GO:0051135,GO:0070062,GO:0071682,GO:1900034" adenyl-nucleotide exchange factor activity|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|microtubule|receptor-mediated endocytosis|response to unfolded protein|protein-containing complex|alpha-tubulin binding|positive regulation of MHC class I biosynthetic process|regulation of catalytic activity|chaperone cofactor-dependent protein refolding|positive regulation of NK T cell activation|extracellular exosome|endocytic vesicle lumen|regulation of cellular response to heat hsa04141 Protein processing in endoplasmic reticulum HTATIP2 1396.090546 1362.942186 1429.238907 1.048642357 0.068522726 0.777240206 1 33.00259505 34.02880241 10553 HIV-1 Tat interactive protein 2 "GO:0001525,GO:0003713,GO:0004674,GO:0005515,GO:0005634,GO:0005635,GO:0005737,GO:0005829,GO:0006357,GO:0006915,GO:0016020,GO:0016032,GO:0016491,GO:0030154,GO:0043066,GO:0043068,GO:0045765,GO:0045944,GO:0046777,GO:0051170,GO:0055114" angiogenesis|transcription coactivator activity|protein serine/threonine kinase activity|protein binding|nucleus|nuclear envelope|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|apoptotic process|membrane|viral process|oxidoreductase activity|cell differentiation|negative regulation of apoptotic process|positive regulation of programmed cell death|regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|protein autophosphorylation|import into nucleus|oxidation-reduction process HTATSF1 1548.864039 1487.791852 1609.936226 1.082097757 0.113830839 0.634366377 1 27.31362804 29.06143574 27336 HIV-1 Tat specific factor 1 "GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005684,GO:0005686,GO:0006357,GO:0019079,GO:0032784" "mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|U2-type spliceosomal complex|U2 snRNP|regulation of transcription by RNA polymerase II|viral genome replication|regulation of DNA-templated transcription, elongation" HTR1B 5.643018428 9.363724944 1.922311912 0.205293505 -2.284240111 0.166157707 1 0.194596881 0.039280975 3351 5-hydroxytryptamine receptor 1B "GO:0002031,GO:0004993,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007187,GO:0007193,GO:0007198,GO:0007205,GO:0007268,GO:0008144,GO:0014053,GO:0014059,GO:0014063,GO:0030425,GO:0030594,GO:0032229,GO:0035690,GO:0042220,GO:0042310,GO:0042756,GO:0044305,GO:0045471,GO:0046849,GO:0050795,GO:0051378,GO:0051385,GO:0051967,GO:0071312,GO:0071502,GO:0098666,GO:0099056,GO:0099154,GO:0099171,GO:0099509,GO:0099626,GO:1904707,GO:2000300" "G protein-coupled receptor internalization|G protein-coupled serotonin receptor activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting serotonin receptor signaling pathway|protein kinase C-activating G protein-coupled receptor signaling pathway|chemical synaptic transmission|drug binding|negative regulation of gamma-aminobutyric acid secretion|regulation of dopamine secretion|negative regulation of serotonin secretion|dendrite|neurotransmitter receptor activity|negative regulation of synaptic transmission, GABAergic|cellular response to drug|response to cocaine|vasoconstriction|drinking behavior|calyx of Held|response to ethanol|bone remodeling|regulation of behavior|serotonin binding|response to mineralocorticoid|negative regulation of synaptic transmission, glutamatergic|cellular response to alkaloid|cellular response to temperature stimulus|G protein-coupled serotonin receptor complex|integral component of presynaptic membrane|serotonergic synapse|presynaptic modulation of chemical synaptic transmission|regulation of presynaptic cytosolic calcium ion concentration|voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels|positive regulation of vascular associated smooth muscle cell proliferation|regulation of synaptic vesicle exocytosis" "hsa04024,hsa04080,hsa04726,hsa04742" cAMP signaling pathway|Neuroactive ligand-receptor interaction|Serotonergic synapse|Taste transduction HTR1D 36.78623782 44.73779695 28.83467868 0.64452612 -0.633689269 0.352636617 1 0.719365471 0.455891284 3352 5-hydroxytryptamine receptor 1D "GO:0004993,GO:0005886,GO:0005887,GO:0007186,GO:0007187,GO:0007193,GO:0007198,GO:0007268,GO:0014827,GO:0030425,GO:0030594,GO:0040012,GO:0042310,GO:0045202,GO:0050795,GO:0051378" "G protein-coupled serotonin receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting serotonin receptor signaling pathway|chemical synaptic transmission|intestine smooth muscle contraction|dendrite|neurotransmitter receptor activity|regulation of locomotion|vasoconstriction|synapse|regulation of behavior|serotonin binding" "hsa04024,hsa04080,hsa04726,hsa04742" cAMP signaling pathway|Neuroactive ligand-receptor interaction|Serotonergic synapse|Taste transduction HTR1F 5.405244648 3.121241648 7.689247648 2.463522058 1.300722389 0.455625732 1 0.0447061 0.108291513 3355 5-hydroxytryptamine receptor 1F "GO:0004993,GO:0005886,GO:0005887,GO:0007186,GO:0007187,GO:0007193,GO:0007198,GO:0007268,GO:0030425,GO:0030594,GO:0045202,GO:0051378" "G protein-coupled serotonin receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting serotonin receptor signaling pathway|chemical synaptic transmission|dendrite|neurotransmitter receptor activity|synapse|serotonin binding" "hsa04024,hsa04080,hsa04726,hsa04742" cAMP signaling pathway|Neuroactive ligand-receptor interaction|Serotonergic synapse|Taste transduction HTR7 585.4396705 557.6618411 613.2174999 1.099622486 0.137008313 0.607713482 1 5.29279522 5.722685536 3363 5-hydroxytryptamine receptor 7 "GO:0004993,GO:0005515,GO:0005886,GO:0005887,GO:0006939,GO:0007186,GO:0007187,GO:0007268,GO:0007623,GO:0008015,GO:0030425,GO:0030594,GO:0042310,GO:0045202,GO:0098664" "G protein-coupled serotonin receptor activity|protein binding|plasma membrane|integral component of plasma membrane|smooth muscle contraction|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|chemical synaptic transmission|circadian rhythm|blood circulation|dendrite|neurotransmitter receptor activity|vasoconstriction|synapse|G protein-coupled serotonin receptor signaling pathway" "hsa04014,hsa04020,hsa04080,hsa04726" Ras signaling pathway|Calcium signaling pathway|Neuroactive ligand-receptor interaction|Serotonergic synapse HTRA1 223.0712414 191.4361544 254.7063283 1.330502742 0.411971483 0.238801871 1 4.885985517 6.392034756 5654 HtrA serine peptidase 1 "GO:0001890,GO:0004252,GO:0005515,GO:0005520,GO:0005576,GO:0005615,GO:0005829,GO:0005886,GO:0006508,GO:0008236,GO:0022617,GO:0030512,GO:0030514,GO:0042802,GO:0050679,GO:0050687,GO:0060718,GO:0062023,GO:0070062,GO:0097187" placenta development|serine-type endopeptidase activity|protein binding|insulin-like growth factor binding|extracellular region|extracellular space|cytosol|plasma membrane|proteolysis|serine-type peptidase activity|extracellular matrix disassembly|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|identical protein binding|positive regulation of epithelial cell proliferation|negative regulation of defense response to virus|chorionic trophoblast cell differentiation|collagen-containing extracellular matrix|extracellular exosome|dentinogenesis HTRA2 853.531142 833.37152 873.690764 1.048380876 0.068162942 0.788842384 1 18.98229038 19.56765944 27429 HtrA serine peptidase 2 "GO:0000785,GO:0004252,GO:0005515,GO:0005634,GO:0005739,GO:0005758,GO:0005783,GO:0005789,GO:0005829,GO:0005856,GO:0006508,GO:0006672,GO:0007005,GO:0007568,GO:0007628,GO:0008233,GO:0008236,GO:0008630,GO:0009635,GO:0009898,GO:0010822,GO:0012501,GO:0016020,GO:0016540,GO:0019742,GO:0030900,GO:0031966,GO:0034599,GO:0034605,GO:0035458,GO:0035631,GO:0040014,GO:0042802,GO:0043065,GO:0043280,GO:0044257,GO:0045786,GO:0048666,GO:0051082,GO:0071300,GO:0071363,GO:0097194,GO:1901215,GO:1902176,GO:1903146,GO:1903955,GO:1904924,GO:1905370,GO:2001241,GO:2001269" chromatin|serine-type endopeptidase activity|protein binding|nucleus|mitochondrion|mitochondrial intermembrane space|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|cytoskeleton|proteolysis|ceramide metabolic process|mitochondrion organization|aging|adult walking behavior|peptidase activity|serine-type peptidase activity|intrinsic apoptotic signaling pathway in response to DNA damage|response to herbicide|cytoplasmic side of plasma membrane|positive regulation of mitochondrion organization|programmed cell death|membrane|protein autoprocessing|pentacyclic triterpenoid metabolic process|forebrain development|mitochondrial membrane|cellular response to oxidative stress|cellular response to heat|cellular response to interferon-beta|CD40 receptor complex|regulation of multicellular organism growth|identical protein binding|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|cellular protein catabolic process|negative regulation of cell cycle|neuron development|unfolded protein binding|cellular response to retinoic acid|cellular response to growth factor stimulus|execution phase of apoptosis|negative regulation of neuron death|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion|negative regulation of mitophagy in response to mitochondrial depolarization|serine-type endopeptidase complex|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway "hsa04210,hsa04215,hsa05012,hsa05022" Apoptosis|Apoptosis - multiple species|Parkinson disease|Pathways of neurodegeneration - multiple diseases HTT 2988.081458 3061.938057 2914.224859 0.951758267 -0.071332899 0.764157272 1 12.12960262 11.35126884 3064 huntingtin "GO:0000132,GO:0002039,GO:0005515,GO:0005522,GO:0005634,GO:0005654,GO:0005737,GO:0005769,GO:0005770,GO:0005776,GO:0005783,GO:0005794,GO:0005814,GO:0005829,GO:0006890,GO:0006915,GO:0007030,GO:0016234,GO:0019900,GO:0030424,GO:0030425,GO:0030659,GO:0031072,GO:0031587,GO:0031648,GO:0032991,GO:0034452,GO:0042297,GO:0042802,GO:0043065,GO:0043666,GO:0044325,GO:0045505,GO:0045724,GO:0047496,GO:0048471,GO:0048487,GO:0099111,GO:0099523,GO:0099524,GO:1903599,GO:1904504,GO:1905289,GO:1905337,GO:2000479,GO:2001237" "establishment of mitotic spindle orientation|p53 binding|protein binding|profilin binding|nucleus|nucleoplasm|cytoplasm|early endosome|late endosome|autophagosome|endoplasmic reticulum|Golgi apparatus|centriole|cytosol|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|apoptotic process|Golgi organization|inclusion body|kinase binding|axon|dendrite|cytoplasmic vesicle membrane|heat shock protein binding|positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|protein destabilization|protein-containing complex|dynactin binding|vocal learning|identical protein binding|positive regulation of apoptotic process|regulation of phosphoprotein phosphatase activity|ion channel binding|dynein intermediate chain binding|positive regulation of cilium assembly|vesicle transport along microtubule|perinuclear region of cytoplasm|beta-tubulin binding|microtubule-based transport|presynaptic cytosol|postsynaptic cytosol|positive regulation of autophagy of mitochondrion|positive regulation of lipophagy|regulation of CAMKK-AMPK signaling cascade|positive regulation of aggrephagy|regulation of cAMP-dependent protein kinase activity|negative regulation of extrinsic apoptotic signaling pathway" "hsa05016,hsa05022" Huntington disease|Pathways of neurodegeneration - multiple diseases HUS1 325.1859017 311.0837509 339.2880525 1.090664657 0.125207589 0.690391046 1 5.41662905 5.808868073 3364 HUS1 checkpoint clamp component "GO:0000077,GO:0000723,GO:0000724,GO:0001932,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006260,GO:0006281,GO:0006289,GO:0006468,GO:0006974,GO:0009411,GO:0009792,GO:0030896,GO:0031573,GO:0033314,GO:0035861,GO:0044778,GO:0071479,GO:1901796" DNA damage checkpoint|telomere maintenance|double-strand break repair via homologous recombination|regulation of protein phosphorylation|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|DNA replication|DNA repair|nucleotide-excision repair|protein phosphorylation|cellular response to DNA damage stimulus|response to UV|embryo development ending in birth or egg hatching|checkpoint clamp complex|intra-S DNA damage checkpoint|mitotic DNA replication checkpoint|site of double-strand break|meiotic DNA integrity checkpoint|cellular response to ionizing radiation|regulation of signal transduction by p53 class mediator hsa04218 Cellular senescence HUWE1 10034.75161 11223.98497 8845.518263 0.788090708 -0.343566403 0.171964394 1 31.73528206 24.59176774 10075 "HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1" "GO:0000139,GO:0000209,GO:0003677,GO:0003723,GO:0004842,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006284,GO:0006513,GO:0007030,GO:0010637,GO:0016020,GO:0016567,GO:0016574,GO:0030154,GO:0031398,GO:0032922,GO:0034774,GO:0043161,GO:0043312,GO:0045732,GO:0061025,GO:0061630,GO:0070062,GO:0098779,GO:1903955,GO:1904813" Golgi membrane|protein polyubiquitination|DNA binding|RNA binding|ubiquitin-protein transferase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|base-excision repair|protein monoubiquitination|Golgi organization|negative regulation of mitochondrial fusion|membrane|protein ubiquitination|histone ubiquitination|cell differentiation|positive regulation of protein ubiquitination|circadian regulation of gene expression|secretory granule lumen|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|positive regulation of protein catabolic process|membrane fusion|ubiquitin protein ligase activity|extracellular exosome|positive regulation of mitophagy in response to mitochondrial depolarization|positive regulation of protein targeting to mitochondrion|ficolin-1-rich granule lumen hsa04120 Ubiquitin mediated proteolysis HVCN1 14.05061783 15.60620824 12.49502743 0.800644669 -0.320765987 0.805610112 1 0.33103126 0.260603355 84329 hydrogen voltage gated channel 1 "GO:0005886,GO:0005887,GO:0009268,GO:0010043,GO:0016021,GO:0016324,GO:0022843,GO:0030171,GO:0030667,GO:0030670,GO:0032930,GO:0034765,GO:0035036,GO:0035579,GO:0042802,GO:0043312,GO:0045454,GO:0051453,GO:0071294,GO:0071467,GO:1902600" plasma membrane|integral component of plasma membrane|response to pH|response to zinc ion|integral component of membrane|apical plasma membrane|voltage-gated cation channel activity|voltage-gated proton channel activity|secretory granule membrane|phagocytic vesicle membrane|positive regulation of superoxide anion generation|regulation of ion transmembrane transport|sperm-egg recognition|specific granule membrane|identical protein binding|neutrophil degranulation|cell redox homeostasis|regulation of intracellular pH|cellular response to zinc ion|cellular response to pH|proton transmembrane transport HYAL1 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.073836405 0.033535088 3373 hyaluronidase 1 "GO:0000302,GO:0001618,GO:0004415,GO:0005615,GO:0005737,GO:0005764,GO:0005975,GO:0006954,GO:0008134,GO:0009615,GO:0010634,GO:0030207,GO:0030212,GO:0030213,GO:0030214,GO:0030307,GO:0030308,GO:0031410,GO:0036117,GO:0036120,GO:0043202,GO:0044344,GO:0045766,GO:0045785,GO:0045927,GO:0046677,GO:0046718,GO:0050501,GO:0050679,GO:0051216,GO:0060272,GO:0070062,GO:0071347,GO:0071356,GO:0071467,GO:0071493,GO:1900087,GO:1900106" response to reactive oxygen species|virus receptor activity|hyalurononglucosaminidase activity|extracellular space|cytoplasm|lysosome|carbohydrate metabolic process|inflammatory response|transcription factor binding|response to virus|positive regulation of epithelial cell migration|chondroitin sulfate catabolic process|hyaluronan metabolic process|hyaluronan biosynthetic process|hyaluronan catabolic process|positive regulation of cell growth|negative regulation of cell growth|cytoplasmic vesicle|hyaluranon cable|cellular response to platelet-derived growth factor stimulus|lysosomal lumen|cellular response to fibroblast growth factor stimulus|positive regulation of angiogenesis|positive regulation of cell adhesion|positive regulation of growth|response to antibiotic|viral entry into host cell|hyaluronan synthase activity|positive regulation of epithelial cell proliferation|cartilage development|embryonic skeletal joint morphogenesis|extracellular exosome|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to pH|cellular response to UV-B|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of hyaluranon cable assembly "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome HYAL2 615.2600429 596.1571548 634.362931 1.064086753 0.089615776 0.736819338 1 12.08807434 12.64751891 8692 hyaluronidase 2 "GO:0000139,GO:0000302,GO:0001618,GO:0001822,GO:0002244,GO:0003713,GO:0004415,GO:0005515,GO:0005540,GO:0005737,GO:0005764,GO:0005783,GO:0005829,GO:0005886,GO:0005902,GO:0005975,GO:0006027,GO:0009615,GO:0009986,GO:0010259,GO:0010764,GO:0016324,GO:0019064,GO:0019087,GO:0019899,GO:0030139,GO:0030214,GO:0030294,GO:0030308,GO:0030971,GO:0031362,GO:0031410,GO:0032755,GO:0032757,GO:0033906,GO:0035810,GO:0042117,GO:0042307,GO:0043407,GO:0044344,GO:0045121,GO:0045944,GO:0046658,GO:0046677,GO:0046718,GO:0048471,GO:0048705,GO:0050431,GO:0050729,GO:0051216,GO:0051607,GO:0051898,GO:0060586,GO:0061099,GO:0070295,GO:0071347,GO:0071356,GO:0071493,GO:0071560,GO:0090575,GO:2001238" Golgi membrane|response to reactive oxygen species|virus receptor activity|kidney development|hematopoietic progenitor cell differentiation|transcription coactivator activity|hyalurononglucosaminidase activity|protein binding|hyaluronic acid binding|cytoplasm|lysosome|endoplasmic reticulum|cytosol|plasma membrane|microvillus|carbohydrate metabolic process|glycosaminoglycan catabolic process|response to virus|cell surface|multicellular organism aging|negative regulation of fibroblast migration|apical plasma membrane|fusion of virus membrane with host plasma membrane|transformation of host cell by virus|enzyme binding|endocytic vesicle|hyaluronan catabolic process|receptor signaling protein tyrosine kinase inhibitor activity|negative regulation of cell growth|receptor tyrosine kinase binding|anchored component of external side of plasma membrane|cytoplasmic vesicle|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|hyaluronoglucuronidase activity|positive regulation of urine volume|monocyte activation|positive regulation of protein import into nucleus|negative regulation of MAP kinase activity|cellular response to fibroblast growth factor stimulus|membrane raft|positive regulation of transcription by RNA polymerase II|anchored component of plasma membrane|response to antibiotic|viral entry into host cell|perinuclear region of cytoplasm|skeletal system morphogenesis|transforming growth factor beta binding|positive regulation of inflammatory response|cartilage development|defense response to virus|negative regulation of protein kinase B signaling|multicellular organismal iron ion homeostasis|negative regulation of protein tyrosine kinase activity|renal water absorption|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to UV-B|cellular response to transforming growth factor beta stimulus|RNA polymerase II transcription regulator complex|positive regulation of extrinsic apoptotic signaling pathway "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome HYAL3 76.86732439 62.42483296 91.30981582 1.462716222 0.548649903 0.288763299 1 1.736964861 2.498171728 8372 hyaluronidase 3 "GO:0001552,GO:0001618,GO:0001669,GO:0002080,GO:0004415,GO:0005515,GO:0005576,GO:0005764,GO:0005769,GO:0005783,GO:0005886,GO:0005975,GO:0006954,GO:0007341,GO:0009615,GO:0030214,GO:0031410,GO:0033906,GO:0046677,GO:0046718,GO:0051216,GO:0071347,GO:0071356,GO:0071493,GO:0097225,GO:2000355,GO:2000368" ovarian follicle atresia|virus receptor activity|acrosomal vesicle|acrosomal membrane|hyalurononglucosaminidase activity|protein binding|extracellular region|lysosome|early endosome|endoplasmic reticulum|plasma membrane|carbohydrate metabolic process|inflammatory response|penetration of zona pellucida|response to virus|hyaluronan catabolic process|cytoplasmic vesicle|hyaluronoglucuronidase activity|response to antibiotic|viral entry into host cell|cartilage development|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to UV-B|sperm midpiece|negative regulation of ovarian follicle development|positive regulation of acrosomal vesicle exocytosis "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome HYI 952.6490924 836.4927616 1068.805423 1.277722261 0.353574272 0.152255243 1 26.18303887 32.89483335 81888 hydroxypyruvate isomerase (putative) "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0008903,GO:0046487" molecular_function|protein binding|cellular_component|biological_process|hydroxypyruvate isomerase activity|glyoxylate metabolic process hsa00630 Glyoxylate and dicarboxylate metabolism HYKK 109.3283604 107.1626299 111.4940909 1.04041951 0.057165358 0.920813413 1 1.339047671 1.369858486 123688 hydroxylysine kinase "GO:0005759,GO:0006554,GO:0016310,GO:0019202,GO:0047992" mitochondrial matrix|lysine catabolic process|phosphorylation|amino acid kinase activity|hydroxylysine kinase activity hsa00310 Lysine degradation HYLS1 329.9665294 373.5085839 286.4244749 0.76684844 -0.382986623 0.210373642 1 8.906821556 6.715888366 219844 HYLS1 centriolar and ciliogenesis associated "GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0005929,GO:0060271,GO:0097730" protein binding|nucleus|cytoplasm|centrosome|centriole|cytosol|plasma membrane|cilium|cilium assembly|non-motile cilium HYOU1 4224.986222 4510.194181 3939.778264 0.873527415 -0.195075113 0.413586863 1 50.84511493 43.67138359 10525 hypoxia up-regulated 1 "GO:0000774,GO:0002931,GO:0005515,GO:0005524,GO:0005576,GO:0005783,GO:0005788,GO:0005790,GO:0005925,GO:0006888,GO:0006898,GO:0016020,GO:0034663,GO:0034976,GO:0036498,GO:0050790,GO:0051082,GO:0051087,GO:0070062,GO:0071456,GO:0071682,GO:1903298" adenyl-nucleotide exchange factor activity|response to ischemia|protein binding|ATP binding|extracellular region|endoplasmic reticulum|endoplasmic reticulum lumen|smooth endoplasmic reticulum|focal adhesion|endoplasmic reticulum to Golgi vesicle-mediated transport|receptor-mediated endocytosis|membrane|endoplasmic reticulum chaperone complex|response to endoplasmic reticulum stress|IRE1-mediated unfolded protein response|regulation of catalytic activity|unfolded protein binding|chaperone binding|extracellular exosome|cellular response to hypoxia|endocytic vesicle lumen|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway hsa04141 Protein processing in endoplasmic reticulum HYPK 372.7033709 359.9832034 385.4235384 1.070670894 0.098515089 0.745534862 1 6.0243468 6.342159209 25764 huntingtin interacting protein K "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0015630,GO:0032991,GO:0043066,GO:0047485,GO:0050821" protein binding|nucleus|nucleoplasm|cytoplasm|microtubule cytoskeleton|protein-containing complex|negative regulation of apoptotic process|protein N-terminus binding|protein stabilization IAH1 539.0072746 499.3986637 578.6158855 1.158625218 0.212413971 0.431384536 1 13.59795348 15.49129437 285148 isoamyl acetate hydrolyzing esterase 1 (putative) "GO:0016042,GO:0016787,GO:0042802" lipid catabolic process|hydrolase activity|identical protein binding IARS1 6944.693276 8197.420981 5691.965571 0.694360529 -0.526243154 0.031538092 0.904158095 91.08500761 62.18750071 3376 isoleucyl-tRNA synthetase 1 "GO:0000049,GO:0001649,GO:0002161,GO:0004822,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006418,GO:0006428,GO:0016020,GO:0017101,GO:0051020,GO:0070062,GO:0106074" tRNA binding|osteoblast differentiation|aminoacyl-tRNA editing activity|isoleucine-tRNA ligase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|cytosol|tRNA aminoacylation for protein translation|isoleucyl-tRNA aminoacylation|membrane|aminoacyl-tRNA synthetase multienzyme complex|GTPase binding|extracellular exosome|aminoacyl-tRNA metabolism involved in translational fidelity hsa00970 Aminoacyl-tRNA biosynthesis IARS2 4258.475653 4089.866973 4427.084333 1.082451914 0.114302937 0.632330348 1 61.83248824 65.81070071 55699 "isoleucyl-tRNA synthetase 2, mitochondrial" "GO:0000049,GO:0002161,GO:0004822,GO:0005524,GO:0005739,GO:0005759,GO:0006418,GO:0006428,GO:0032543,GO:0106074" tRNA binding|aminoacyl-tRNA editing activity|isoleucine-tRNA ligase activity|ATP binding|mitochondrion|mitochondrial matrix|tRNA aminoacylation for protein translation|isoleucyl-tRNA aminoacylation|mitochondrial translation|aminoacyl-tRNA metabolism involved in translational fidelity hsa00970 Aminoacyl-tRNA biosynthesis IBA57 105.0031586 107.1626299 102.8436873 0.959697307 -0.059348651 0.918776793 1 0.726785183 0.685822168 200205 iron-sulfur cluster assembly factor IBA57 "GO:0003723,GO:0005515,GO:0005739,GO:0005759,GO:0006783,GO:0016226,GO:0016740" RNA binding|protein binding|mitochondrion|mitochondrial matrix|heme biosynthetic process|iron-sulfur cluster assembly|transferase activity IBTK 1491.392827 1492.993922 1489.791732 0.997855189 -0.003097631 0.992850207 1 12.92220915 12.67872156 25998 inhibitor of Bruton tyrosine kinase "GO:0001933,GO:0005654,GO:0005737,GO:0016020,GO:0019901,GO:0030292,GO:0051209,GO:0061099" negative regulation of protein phosphorylation|nucleoplasm|cytoplasm|membrane|protein kinase binding|protein tyrosine kinase inhibitor activity|release of sequestered calcium ion into cytosol|negative regulation of protein tyrosine kinase activity ICA1 251.172477 222.6485709 279.6963832 1.256223573 0.329093247 0.327253963 1 3.881850708 4.794871205 3382 islet cell autoantigen 1 "GO:0000139,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0006836,GO:0019904,GO:0030667,GO:0030672,GO:0043231,GO:0050796,GO:0051049,GO:0140090" Golgi membrane|protein binding|cytoplasm|Golgi apparatus|cytosol|neurotransmitter transport|protein domain specific binding|secretory granule membrane|synaptic vesicle membrane|intracellular membrane-bounded organelle|regulation of insulin secretion|regulation of transport|membrane curvature sensor activity hsa04940 Type I diabetes mellitus ICA1L 94.39584454 93.63724944 95.15443964 1.016202849 0.023188414 0.986528457 1 0.571898364 0.571439742 130026 islet cell autoantigen 1 like "GO:0005515,GO:0005794,GO:0019904,GO:0051049" protein binding|Golgi apparatus|protein domain specific binding|regulation of transport ICAM1 5407.440293 5424.717984 5390.162601 0.993630013 -0.009219343 0.970303569 1 97.5757427 95.33178949 3383 intercellular adhesion molecule 1 "GO:0001541,GO:0001618,GO:0001772,GO:0001910,GO:0001975,GO:0002291,GO:0002438,GO:0002457,GO:0002693,GO:0004888,GO:0005178,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0005925,GO:0007155,GO:0007157,GO:0007159,GO:0007569,GO:0007605,GO:0008360,GO:0009897,GO:0009986,GO:0010212,GO:0010477,GO:0016020,GO:0019221,GO:0022614,GO:0030198,GO:0030838,GO:0031669,GO:0032868,GO:0033627,GO:0034698,GO:0038023,GO:0042493,GO:0043200,GO:0043547,GO:0044406,GO:0045121,GO:0045429,GO:0045471,GO:0045907,GO:0046688,GO:0046718,GO:0046813,GO:0050731,GO:0050776,GO:0050900,GO:0051092,GO:0051926,GO:0060333,GO:0061028,GO:0062023,GO:0070062,GO:0070374,GO:0071222,GO:0071312,GO:0071333,GO:0071347,GO:0071354,GO:0071356,GO:0071456,GO:0071549,GO:0072683,GO:0090557,GO:0097368,GO:1900027,GO:1902042,GO:1904646,GO:1904996,GO:1990830,GO:2000352" ovarian follicle development|virus receptor activity|immunological synapse|regulation of leukocyte mediated cytotoxicity|response to amphetamine|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|acute inflammatory response to antigenic stimulus|T cell antigen processing and presentation|positive regulation of cellular extravasation|transmembrane signaling receptor activity|integrin binding|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|focal adhesion|cell adhesion|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|leukocyte cell-cell adhesion|cell aging|sensory perception of sound|regulation of cell shape|external side of plasma membrane|cell surface|response to ionizing radiation|response to sulfur dioxide|membrane|cytokine-mediated signaling pathway|membrane to membrane docking|extracellular matrix organization|positive regulation of actin filament polymerization|cellular response to nutrient levels|response to insulin|cell adhesion mediated by integrin|response to gonadotropin|signaling receptor activity|response to drug|response to amino acid|positive regulation of GTPase activity|adhesion of symbiont to host|membrane raft|positive regulation of nitric oxide biosynthetic process|response to ethanol|positive regulation of vasoconstriction|response to copper ion|viral entry into host cell|receptor-mediated virion attachment to host cell|positive regulation of peptidyl-tyrosine phosphorylation|regulation of immune response|leukocyte migration|positive regulation of NF-kappaB transcription factor activity|negative regulation of calcium ion transport|interferon-gamma-mediated signaling pathway|establishment of endothelial barrier|collagen-containing extracellular matrix|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|cellular response to lipopolysaccharide|cellular response to alkaloid|cellular response to glucose stimulus|cellular response to interleukin-1|cellular response to interleukin-6|cellular response to tumor necrosis factor|cellular response to hypoxia|cellular response to dexamethasone stimulus|T cell extravasation|establishment of endothelial intestinal barrier|establishment of Sertoli cell barrier|regulation of ruffle assembly|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|cellular response to amyloid-beta|positive regulation of leukocyte adhesion to vascular endothelial cell|cellular response to leukemia inhibitory factor|negative regulation of endothelial cell apoptotic process "hsa04064,hsa04514,hsa04650,hsa04668,hsa04670,hsa04933,hsa05143,hsa05144,hsa05150,hsa05164,hsa05166,hsa05167,hsa05169,hsa05323,hsa05416,hsa05418" NF-kappa B signaling pathway|Cell adhesion molecules|Natural killer cell mediated cytotoxicity|TNF signaling pathway|Leukocyte transendothelial migration|AGE-RAGE signaling pathway in diabetic complications|African trypanosomiasis|Malaria|Staphylococcus aureus infection|Influenza A|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Rheumatoid arthritis|Viral myocarditis|Fluid shear stress and atherosclerosis ICAM2 178.5114676 157.1024963 199.9204388 1.272547818 0.347719869 0.362995533 1 6.160375815 7.708191514 3384 intercellular adhesion molecule 2 "GO:0001931,GO:0002223,GO:0005178,GO:0005886,GO:0005887,GO:0005902,GO:0007155,GO:0016020,GO:0030198,GO:0032154,GO:0050776,GO:0098609" uropod|stimulatory C-type lectin receptor signaling pathway|integrin binding|plasma membrane|integral component of plasma membrane|microvillus|cell adhesion|membrane|extracellular matrix organization|cleavage furrow|regulation of immune response|cell-cell adhesion "hsa04514,hsa04650" Cell adhesion molecules|Natural killer cell mediated cytotoxicity ICAM3 133.5900027 125.8900798 141.2899255 1.122327714 0.166493998 0.706681155 1 3.306359342 3.648723197 3385 intercellular adhesion molecule 3 "GO:0002223,GO:0005102,GO:0005178,GO:0005515,GO:0005886,GO:0005887,GO:0006909,GO:0007155,GO:0030198,GO:0050776,GO:0070062,GO:0098609" stimulatory C-type lectin receptor signaling pathway|signaling receptor binding|integrin binding|protein binding|plasma membrane|integral component of plasma membrane|phagocytosis|cell adhesion|extracellular matrix organization|regulation of immune response|extracellular exosome|cell-cell adhesion hsa04514 Cell adhesion molecules ICAM4 3.403674809 1.040413883 5.766935736 5.54292463 2.470647391 0.304382079 1 0.043042618 0.234589639 3386 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) "GO:0005178,GO:0005576,GO:0005886,GO:0005887,GO:0007155,GO:0016021,GO:0030198,GO:0050776,GO:0098609" integrin binding|extracellular region|plasma membrane|integral component of plasma membrane|cell adhesion|integral component of membrane|extracellular matrix organization|regulation of immune response|cell-cell adhesion ICAM5 353.8520037 331.8920286 375.8119788 1.132332043 0.179297074 0.553859364 1 5.698992141 6.345166665 7087 intercellular adhesion molecule 5 "GO:0005178,GO:0005515,GO:0005886,GO:0005887,GO:0006909,GO:0007155,GO:0030198,GO:0050776,GO:0098609" integrin binding|protein binding|plasma membrane|integral component of plasma membrane|phagocytosis|cell adhesion|extracellular matrix organization|regulation of immune response|cell-cell adhesion ICE1 1948.057106 2101.636043 1794.47817 0.853848208 -0.227948475 0.335743201 1 13.61005375 11.42645965 23379 interactor of little elongation complex ELL subunit 1 "GO:0005515,GO:0005654,GO:0008023,GO:0015030,GO:0016604,GO:0030674,GO:0031334,GO:0035327,GO:0035363,GO:0042795,GO:0042796,GO:0045945,GO:0090316" protein binding|nucleoplasm|transcription elongation factor complex|Cajal body|nuclear body|protein-macromolecule adaptor activity|positive regulation of protein-containing complex assembly|transcriptionally active chromatin|histone locus body|snRNA transcription by RNA polymerase II|snRNA transcription by RNA polymerase III|positive regulation of transcription by RNA polymerase III|positive regulation of intracellular protein transport other ICE2 914.6035598 935.3320805 893.8750391 0.95567666 -0.065405509 0.795624791 1 5.101896368 4.794173988 79664 interactor of little elongation complex ELL subunit 2 "GO:0005515,GO:0005654,GO:0005829,GO:0008023,GO:0015030,GO:0016604,GO:0035327,GO:0035363,GO:0042795,GO:0042796,GO:0045945" protein binding|nucleoplasm|cytosol|transcription elongation factor complex|Cajal body|nuclear body|transcriptionally active chromatin|histone locus body|snRNA transcription by RNA polymerase II|snRNA transcription by RNA polymerase III|positive regulation of transcription by RNA polymerase III other ICMT 2676.819684 2384.628619 2969.010748 1.245062113 0.316217717 0.181229253 1 26.22902857 32.11030293 23463 isoprenylcysteine carboxyl methyltransferase "GO:0003880,GO:0004671,GO:0005515,GO:0005783,GO:0005789,GO:0006464,GO:0006481,GO:0006612,GO:0016020,GO:0016021,GO:0043687" protein C-terminal carboxyl O-methyltransferase activity|protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cellular protein modification process|C-terminal protein methylation|protein targeting to membrane|membrane|integral component of membrane|post-translational protein modification hsa00900 Terpenoid backbone biosynthesis ICOSLG 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.01619158 23308 inducible T cell costimulator ligand "GO:0001817,GO:0002250,GO:0005102,GO:0005515,GO:0005886,GO:0006952,GO:0006972,GO:0007165,GO:0009897,GO:0016021,GO:0031295,GO:0036464,GO:0042104,GO:0042110,GO:0042113,GO:0042802,GO:0050852,GO:0070062" regulation of cytokine production|adaptive immune response|signaling receptor binding|protein binding|plasma membrane|defense response|hyperosmotic response|signal transduction|external side of plasma membrane|integral component of membrane|T cell costimulation|cytoplasmic ribonucleoprotein granule|positive regulation of activated T cell proliferation|T cell activation|B cell activation|identical protein binding|T cell receptor signaling pathway|extracellular exosome "hsa04514,hsa04672" Cell adhesion molecules|Intestinal immune network for IgA production ID1 1320.221434 910.3621473 1730.080721 1.900431302 0.926326875 0.00012979 0.044371943 49.42457236 92.35624644 3397 "inhibitor of DNA binding 1, HLH protein" "GO:0000122,GO:0001525,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0005813,GO:0007179,GO:0007420,GO:0008022,GO:0008134,GO:0010621,GO:0010628,GO:0030154,GO:0030182,GO:0032091,GO:0032233,GO:0032922,GO:0036164,GO:0042802,GO:0043066,GO:0043392,GO:0043433,GO:0043534,GO:0045602,GO:0045892,GO:0046983,GO:0047485,GO:0048514,GO:0050679,GO:0050774,GO:0070628,GO:0071364,GO:0120163,GO:0140110,GO:0140416,GO:1901342,GO:1901653,GO:1903351,GO:1990090" "negative regulation of transcription by RNA polymerase II|angiogenesis|protein binding|nucleus|nucleoplasm|Golgi apparatus|centrosome|transforming growth factor beta receptor signaling pathway|brain development|protein C-terminus binding|transcription factor binding|negative regulation of transcription by transcription factor localization|positive regulation of gene expression|cell differentiation|neuron differentiation|negative regulation of protein binding|positive regulation of actin filament bundle assembly|circadian regulation of gene expression|cell-abiotic substrate adhesion|identical protein binding|negative regulation of apoptotic process|negative regulation of DNA binding|negative regulation of DNA-binding transcription factor activity|blood vessel endothelial cell migration|negative regulation of endothelial cell differentiation|negative regulation of transcription, DNA-templated|protein dimerization activity|protein N-terminus binding|blood vessel morphogenesis|positive regulation of epithelial cell proliferation|negative regulation of dendrite morphogenesis|proteasome binding|cellular response to epidermal growth factor stimulus|negative regulation of cold-induced thermogenesis|transcription regulator activity|transcription regulator inhibitor activity|regulation of vasculature development|cellular response to peptide|cellular response to dopamine|cellular response to nerve growth factor stimulus" "hsa04015,hsa04350,hsa04390,hsa04550" Rap1 signaling pathway|TGF-beta signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells ID2 12.41073908 10.40413883 14.41733934 1.385731158 0.470647391 0.70561241 1 0.427444009 0.582410766 3398 inhibitor of DNA binding 2 "GO:0000122,GO:0000791,GO:0001102,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0010628,GO:0010629,GO:0019216,GO:0030154,GO:0032922,GO:0032991,GO:0033598,GO:0042752,GO:0043153,GO:0043433,GO:0044325,GO:0045475,GO:0045664,GO:0045777,GO:0045892,GO:0045893,GO:0046983,GO:0048557,GO:0048661,GO:0048663,GO:0051148,GO:0060749,GO:0061030,GO:0061031,GO:0071158,GO:0071931,GO:0090398,GO:0140110,GO:0140416,GO:2000045,GO:2000177" "negative regulation of transcription by RNA polymerase II|euchromatin|RNA polymerase II activating transcription factor binding|protein binding|nucleus|cytoplasm|cytosol|positive regulation of gene expression|negative regulation of gene expression|regulation of lipid metabolic process|cell differentiation|circadian regulation of gene expression|protein-containing complex|mammary gland epithelial cell proliferation|regulation of circadian rhythm|entrainment of circadian clock by photoperiod|negative regulation of DNA-binding transcription factor activity|ion channel binding|locomotor rhythm|regulation of neuron differentiation|positive regulation of blood pressure|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein dimerization activity|embryonic digestive tract morphogenesis|positive regulation of smooth muscle cell proliferation|neuron fate commitment|negative regulation of muscle cell differentiation|mammary gland alveolus development|epithelial cell differentiation involved in mammary gland alveolus development|endodermal digestive tract morphogenesis|positive regulation of cell cycle arrest|positive regulation of transcription involved in G1/S transition of mitotic cell cycle|cellular senescence|transcription regulator activity|transcription regulator inhibitor activity|regulation of G1/S transition of mitotic cell cycle|regulation of neural precursor cell proliferation" "hsa04350,hsa04390,hsa04550,hsa05202" TGF-beta signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Transcriptional misregulation in cancer ID3 290.6540987 237.2143652 344.0938322 1.450560685 0.536610653 0.091317226 1 13.32599441 19.00669948 3399 "inhibitor of DNA binding 3, HLH protein" "GO:0000122,GO:0001656,GO:0005515,GO:0005634,GO:0005737,GO:0006275,GO:0007275,GO:0007417,GO:0007507,GO:0007517,GO:0008134,GO:0009611,GO:0010628,GO:0019904,GO:0030154,GO:0030182,GO:0030855,GO:0030903,GO:0032922,GO:0042476,GO:0043065,GO:0043433,GO:0045662,GO:0045668,GO:0045892,GO:0046983,GO:0051726,GO:0072750,GO:0140110,GO:0140416,GO:1901707" "negative regulation of transcription by RNA polymerase II|metanephros development|protein binding|nucleus|cytoplasm|regulation of DNA replication|multicellular organism development|central nervous system development|heart development|muscle organ development|transcription factor binding|response to wounding|positive regulation of gene expression|protein domain specific binding|cell differentiation|neuron differentiation|epithelial cell differentiation|notochord development|circadian regulation of gene expression|odontogenesis|positive regulation of apoptotic process|negative regulation of DNA-binding transcription factor activity|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|protein dimerization activity|regulation of cell cycle|cellular response to leptomycin B|transcription regulator activity|transcription regulator inhibitor activity|leptomycin B binding" "hsa04350,hsa04550" TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells bHLH IDE 3263.901806 3338.688149 3189.115462 0.955200162 -0.066125013 0.781213643 1 24.04908224 22.58728718 3416 insulin degrading enzyme "GO:0001540,GO:0001618,GO:0004175,GO:0004222,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005737,GO:0005739,GO:0005777,GO:0005782,GO:0005829,GO:0006508,GO:0006625,GO:0008270,GO:0008286,GO:0008340,GO:0009897,GO:0009986,GO:0010815,GO:0010992,GO:0016323,GO:0016887,GO:0019885,GO:0030163,GO:0031597,GO:0031626,GO:0032092,GO:0042277,GO:0042447,GO:0042803,GO:0043171,GO:0043559,GO:0044257,GO:0044877,GO:0045732,GO:0045861,GO:0046718,GO:0050435,GO:0051603,GO:0070062,GO:0097242,GO:0140036,GO:0150094,GO:1901142,GO:1901143,GO:1903715" amyloid-beta binding|virus receptor activity|endopeptidase activity|metalloendopeptidase activity|protein binding|ATP binding|extracellular space|nucleus|cytoplasm|mitochondrion|peroxisome|peroxisomal matrix|cytosol|proteolysis|protein targeting to peroxisome|zinc ion binding|insulin receptor signaling pathway|determination of adult lifespan|external side of plasma membrane|cell surface|bradykinin catabolic process|ubiquitin recycling|basolateral plasma membrane|ATPase activity|antigen processing and presentation of endogenous peptide antigen via MHC class I|protein catabolic process|cytosolic proteasome complex|beta-endorphin binding|positive regulation of protein binding|peptide binding|hormone catabolic process|protein homodimerization activity|peptide catabolic process|insulin binding|cellular protein catabolic process|protein-containing complex binding|positive regulation of protein catabolic process|negative regulation of proteolysis|viral entry into host cell|amyloid-beta metabolic process|proteolysis involved in cellular protein catabolic process|extracellular exosome|amyloid-beta clearance|ubiquitin-dependent protein binding|amyloid-beta clearance by cellular catabolic process|insulin metabolic process|insulin catabolic process|regulation of aerobic respiration hsa05010 Alzheimer disease IDH1 2668.375028 2768.541342 2568.208714 0.927639648 -0.108363612 0.647557934 1 54.54114546 49.74789802 3417 isocitrate dehydrogenase (NADP(+)) 1 "GO:0000287,GO:0004450,GO:0005515,GO:0005576,GO:0005737,GO:0005739,GO:0005777,GO:0005782,GO:0005829,GO:0006097,GO:0006099,GO:0006102,GO:0006103,GO:0006625,GO:0006739,GO:0006740,GO:0006749,GO:0006979,GO:0008585,GO:0034774,GO:0042802,GO:0042803,GO:0043312,GO:0045296,GO:0048545,GO:0050661,GO:0051287,GO:0060696,GO:0070062,GO:0071071,GO:1904724,GO:1904813" magnesium ion binding|isocitrate dehydrogenase (NADP+) activity|protein binding|extracellular region|cytoplasm|mitochondrion|peroxisome|peroxisomal matrix|cytosol|glyoxylate cycle|tricarboxylic acid cycle|isocitrate metabolic process|2-oxoglutarate metabolic process|protein targeting to peroxisome|NADP metabolic process|NADPH regeneration|glutathione metabolic process|response to oxidative stress|female gonad development|secretory granule lumen|identical protein binding|protein homodimerization activity|neutrophil degranulation|cadherin binding|response to steroid hormone|NADP binding|NAD binding|regulation of phospholipid catabolic process|extracellular exosome|regulation of phospholipid biosynthetic process|tertiary granule lumen|ficolin-1-rich granule lumen "hsa00020,hsa00480,hsa04146,hsa05230" Citrate cycle (TCA cycle)|Glutathione metabolism|Peroxisome|Central carbon metabolism in cancer IDH2 1225.794178 1093.474991 1358.113366 1.242015938 0.312683686 0.195927185 1 21.58163851 26.35619798 3418 isocitrate dehydrogenase (NADP(+)) 2 "GO:0000287,GO:0004450,GO:0005739,GO:0005759,GO:0005777,GO:0005829,GO:0005975,GO:0006097,GO:0006099,GO:0006102,GO:0006103,GO:0006739,GO:0006741,GO:0051287,GO:0060253,GO:0070062,GO:1903976,GO:1904465" magnesium ion binding|isocitrate dehydrogenase (NADP+) activity|mitochondrion|mitochondrial matrix|peroxisome|cytosol|carbohydrate metabolic process|glyoxylate cycle|tricarboxylic acid cycle|isocitrate metabolic process|2-oxoglutarate metabolic process|NADP metabolic process|NADP biosynthetic process|NAD binding|negative regulation of glial cell proliferation|extracellular exosome|negative regulation of glial cell migration|negative regulation of matrix metallopeptidase secretion "hsa00020,hsa00480,hsa04146,hsa05230" Citrate cycle (TCA cycle)|Glutathione metabolism|Peroxisome|Central carbon metabolism in cancer IDH3A 1169.358349 1113.242854 1225.473844 1.100814471 0.138571341 0.569542777 1 20.24249577 21.91035256 3419 isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha "GO:0000287,GO:0004449,GO:0005515,GO:0005634,GO:0005739,GO:0005759,GO:0005975,GO:0006099,GO:0006102,GO:0051287" magnesium ion binding|isocitrate dehydrogenase (NAD+) activity|protein binding|nucleus|mitochondrion|mitochondrial matrix|carbohydrate metabolic process|tricarboxylic acid cycle|isocitrate metabolic process|NAD binding hsa00020 Citrate cycle (TCA cycle) IDH3B 1091.555021 988.3931885 1194.716853 1.208746547 0.273511768 0.262545199 1 28.66778689 34.07223263 3420 isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta "GO:0000287,GO:0004449,GO:0005634,GO:0005739,GO:0005759,GO:0006099,GO:0006102,GO:0009055,GO:0022900,GO:0051287" magnesium ion binding|isocitrate dehydrogenase (NAD+) activity|nucleus|mitochondrion|mitochondrial matrix|tricarboxylic acid cycle|isocitrate metabolic process|electron transfer activity|electron transport chain|NAD binding hsa00020 Citrate cycle (TCA cycle) IDH3G 1610.595673 1543.974202 1677.217143 1.086298684 0.119420835 0.617061763 1 52.38338554 55.95179134 3421 isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma "GO:0000287,GO:0004449,GO:0005515,GO:0005524,GO:0005730,GO:0005739,GO:0005759,GO:0005975,GO:0006099,GO:0006102,GO:0051287" magnesium ion binding|isocitrate dehydrogenase (NAD+) activity|protein binding|ATP binding|nucleolus|mitochondrion|mitochondrial matrix|carbohydrate metabolic process|tricarboxylic acid cycle|isocitrate metabolic process|NAD binding hsa00020 Citrate cycle (TCA cycle) IDI1 576.1105441 552.4597717 599.7613165 1.08561989 0.118519058 0.658989308 1 4.93369522 5.266490287 3422 isopentenyl-diphosphate delta isomerase 1 "GO:0004452,GO:0005737,GO:0005777,GO:0005829,GO:0006695,GO:0009240,GO:0016787,GO:0045540,GO:0046872,GO:0050992" isopentenyl-diphosphate delta-isomerase activity|cytoplasm|peroxisome|cytosol|cholesterol biosynthetic process|isopentenyl diphosphate biosynthetic process|hydrolase activity|regulation of cholesterol biosynthetic process|metal ion binding|dimethylallyl diphosphate biosynthetic process hsa00900 Terpenoid backbone biosynthesis IDNK 78.10085267 82.19269673 74.00900861 0.900432904 -0.151309317 0.78779285 1 0.642236188 0.568613685 414328 IDNK gluconokinase "GO:0003674,GO:0005524,GO:0008150,GO:0016310,GO:0046177,GO:0046316" molecular_function|ATP binding|biological_process|phosphorylation|D-gluconate catabolic process|gluconokinase activity hsa00030 Pentose phosphate pathway IDO1 11.88550172 21.84869154 1.922311912 0.087982931 -3.506632533 0.004953015 0.428880196 0.630624398 0.05455573 3620 "indoleamine 2,3-dioxygenase 1" "GO:0002376,GO:0002666,GO:0002678,GO:0002830,GO:0004833,GO:0005737,GO:0005829,GO:0006569,GO:0006954,GO:0007565,GO:0009055,GO:0019441,GO:0020037,GO:0022900,GO:0030485,GO:0032421,GO:0032496,GO:0032693,GO:0032735,GO:0033555,GO:0033754,GO:0034276,GO:0034354,GO:0036269,GO:0042130,GO:0046006,GO:0046872,GO:0070233,GO:0070234" "immune system process|positive regulation of T cell tolerance induction|positive regulation of chronic inflammatory response|positive regulation of type 2 immune response|tryptophan 2,3-dioxygenase activity|cytoplasm|cytosol|tryptophan catabolic process|inflammatory response|female pregnancy|electron transfer activity|tryptophan catabolic process to kynurenine|heme binding|electron transport chain|smooth muscle contractile fiber|stereocilium bundle|response to lipopolysaccharide|negative regulation of interleukin-10 production|positive regulation of interleukin-12 production|multicellular organismal response to stress|indoleamine 2,3-dioxygenase activity|kynurenic acid biosynthetic process|'de novo' NAD biosynthetic process from tryptophan|swimming behavior|negative regulation of T cell proliferation|regulation of activated T cell proliferation|metal ion binding|negative regulation of T cell apoptotic process|positive regulation of T cell apoptotic process" "hsa00380,hsa05143" Tryptophan metabolism|African trypanosomiasis IDS 7201.626199 7044.642399 7358.609999 1.044568281 0.062906801 0.797647522 1 48.42968148 49.74158562 3423 iduronate 2-sulfatase "GO:0004423,GO:0005509,GO:0005764,GO:0006027,GO:0008484,GO:0030207,GO:0043202" iduronate-2-sulfatase activity|calcium ion binding|lysosome|glycosaminoglycan catabolic process|sulfuric ester hydrolase activity|chondroitin sulfate catabolic process|lysosomal lumen "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome IDUA 68.97490151 69.70773014 68.24207288 0.978974251 -0.030657181 0.984841057 1 1.207064711 1.161911368 3425 alpha-L-iduronidase "GO:0003940,GO:0004553,GO:0005102,GO:0005984,GO:0006027,GO:0030135,GO:0030207,GO:0030209,GO:0030211,GO:0043202,GO:0070062" "L-iduronidase activity|hydrolase activity, hydrolyzing O-glycosyl compounds|signaling receptor binding|disaccharide metabolic process|glycosaminoglycan catabolic process|coated vesicle|chondroitin sulfate catabolic process|dermatan sulfate catabolic process|heparin catabolic process|lysosomal lumen|extracellular exosome" "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome IER2 1147.980175 1094.515405 1201.444945 1.097695784 0.13447828 0.581690453 1 27.68354289 29.87960448 9592 immediate early response 2 "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0030182,GO:0045944,GO:0048870,GO:0071774" DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|neuron differentiation|positive regulation of transcription by RNA polymerase II|cell motility|response to fibroblast growth factor IER3 2846.458065 2498.033732 3194.882398 1.278958869 0.354969869 0.133647631 1 107.7732167 135.5309873 8870 immediate early response 3 "GO:0005515,GO:0005634,GO:0005829,GO:0006915,GO:0009653,GO:0014066,GO:0016021,GO:0043066,GO:2001020" protein binding|nucleus|cytosol|apoptotic process|anatomical structure morphogenesis|regulation of phosphatidylinositol 3-kinase signaling|integral component of membrane|negative regulation of apoptotic process|regulation of response to DNA damage stimulus IER3IP1 1471.519209 920.7662861 2022.272131 2.196292547 1.135070234 2.64E-06 0.001503356 13.35678293 28.84451456 51124 immediate early response 3 interacting protein 1 "GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0006888,GO:0016020,GO:0030134,GO:0030173,GO:2000269" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|endoplasmic reticulum to Golgi vesicle-mediated transport|membrane|COPII-coated ER to Golgi transport vesicle|integral component of Golgi membrane|regulation of fibroblast apoptotic process IER5 2039.433546 1737.491184 2341.375909 1.347561317 0.430350921 0.069035378 1 22.072533 29.24636455 51278 immediate early response 5 "GO:0000159,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0034605,GO:0042127,GO:0042802,GO:0045944,GO:1900036" protein phosphatase type 2A complex|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cellular response to heat|regulation of cell population proliferation|identical protein binding|positive regulation of transcription by RNA polymerase II|positive regulation of cellular response to heat IER5L 93.50891609 108.2030438 78.81478839 0.728397147 -0.457202823 0.343503115 1 2.130847815 1.526131119 389792 immediate early response 5 like IFFO1 516.6232849 492.1157665 541.1308032 1.099600623 0.136979629 0.617746141 1 6.160758618 6.661014037 25900 intermediate filament family orphan 1 "GO:0005515,GO:0005654,GO:0005882,GO:0006303,GO:0016363,GO:0035861,GO:1990166,GO:1990683" protein binding|nucleoplasm|intermediate filament|double-strand break repair via nonhomologous end joining|nuclear matrix|site of double-strand break|protein localization to site of double-strand break|DNA double-strand break attachment to nuclear envelope IFFO2 543.7734254 498.3582498 589.188601 1.18225915 0.241546308 0.369360079 1 4.307119651 5.006921694 126917 intermediate filament family orphan 2 GO:0005882 intermediate filament IFI16 2672.703417 3058.816815 2286.590019 0.747540686 -0.419775993 0.07599412 1 30.71950161 22.57980456 3428 interferon gamma inducible protein 16 "GO:0000122,GO:0000978,GO:0001227,GO:0001819,GO:0002218,GO:0003690,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006914,GO:0006954,GO:0008134,GO:0010506,GO:0016020,GO:0016607,GO:0030099,GO:0030224,GO:0032481,GO:0032731,GO:0035458,GO:0040029,GO:0042149,GO:0042771,GO:0043392,GO:0045071,GO:0045087,GO:0045824,GO:0045892,GO:0045944,GO:0051607,GO:0071479,GO:0072332,GO:0097202,GO:2000117" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|positive regulation of cytokine production|activation of innate immune response|double-stranded DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|autophagy|inflammatory response|transcription factor binding|regulation of autophagy|membrane|nuclear speck|myeloid cell differentiation|monocyte differentiation|positive regulation of type I interferon production|positive regulation of interleukin-1 beta production|cellular response to interferon-beta|regulation of gene expression, epigenetic|cellular response to glucose starvation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of DNA binding|negative regulation of viral genome replication|innate immune response|negative regulation of innate immune response|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|defense response to virus|cellular response to ionizing radiation|intrinsic apoptotic signaling pathway by p53 class mediator|activation of cysteine-type endopeptidase activity|negative regulation of cysteine-type endopeptidase activity" hsa04621 NOD-like receptor signaling pathway IFI27 1556.211717 1440.973227 1671.450207 1.159945359 0.214056846 0.369384483 1 103.0859152 117.5731195 3429 interferon alpha inducible protein 27 "GO:0000122,GO:0001102,GO:0003674,GO:0005515,GO:0005521,GO:0005635,GO:0005637,GO:0005739,GO:0005741,GO:0005789,GO:0006915,GO:0016021,GO:0016032,GO:0031966,GO:0042802,GO:0043161,GO:0044827,GO:0045087,GO:0046825,GO:0051607,GO:0060337,GO:0070936,GO:0097190,GO:0097191" negative regulation of transcription by RNA polymerase II|RNA polymerase II activating transcription factor binding|molecular_function|protein binding|lamin binding|nuclear envelope|nuclear inner membrane|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum membrane|apoptotic process|integral component of membrane|viral process|mitochondrial membrane|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|modulation by host of viral genome replication|innate immune response|regulation of protein export from nucleus|defense response to virus|type I interferon signaling pathway|protein K48-linked ubiquitination|apoptotic signaling pathway|extrinsic apoptotic signaling pathway IFI27L1 569.7340827 574.3084632 565.1597021 0.984069953 -0.023167222 0.937544386 1 8.140713718 7.876977994 122509 interferon alpha inducible protein 27 like 1 "GO:0005515,GO:0005739,GO:0006915,GO:0016021,GO:0097190" protein binding|mitochondrion|apoptotic process|integral component of membrane|apoptotic signaling pathway IFI27L2 454.3368461 421.3676225 487.3060697 1.156486744 0.209748729 0.455988061 1 49.86167532 56.69943146 83982 interferon alpha inducible protein 27 like 2 "GO:0005739,GO:0006915,GO:0016021,GO:0031966,GO:0097190" mitochondrion|apoptotic process|integral component of membrane|mitochondrial membrane|apoptotic signaling pathway IFI30 235.1347662 268.4267817 201.8427508 0.75194714 -0.411296848 0.23003172 1 14.49943724 10.7203666 10437 IFI30 lysosomal thiol reductase "GO:0005515,GO:0005576,GO:0005764,GO:0005829,GO:0016491,GO:0016667,GO:0019886,GO:0030054,GO:0042590,GO:0043202,GO:0043231,GO:0048147,GO:0050821,GO:0055114,GO:0060333" "protein binding|extracellular region|lysosome|cytosol|oxidoreductase activity|oxidoreductase activity, acting on a sulfur group of donors|antigen processing and presentation of exogenous peptide antigen via MHC class II|cell junction|antigen processing and presentation of exogenous peptide antigen via MHC class I|lysosomal lumen|intracellular membrane-bounded organelle|negative regulation of fibroblast proliferation|protein stabilization|oxidation-reduction process|interferon-gamma-mediated signaling pathway" hsa04612 Antigen processing and presentation IFI35 324.244253 362.0640312 286.4244749 0.791087902 -0.338090085 0.271940199 1 13.7920713 10.72816429 3430 interferon induced protein 35 "GO:0002281,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0008285,GO:0016020,GO:0034145,GO:0042802,GO:0045089,GO:0050729,GO:0060337,GO:1901223,GO:1901224" macrophage activation involved in immune response|protein binding|extracellular space|nucleus|cytoplasm|cytosol|negative regulation of cell population proliferation|membrane|positive regulation of toll-like receptor 4 signaling pathway|identical protein binding|positive regulation of innate immune response|positive regulation of inflammatory response|type I interferon signaling pathway|negative regulation of NIK/NF-kappaB signaling|positive regulation of NIK/NF-kappaB signaling IFI44 1396.080486 1387.912119 1404.248852 1.011770725 0.016882402 0.947035546 1 28.58754108 28.44003258 10561 interferon induced protein 44 "GO:0005515,GO:0005737,GO:0006955,GO:0009615,GO:0009617" protein binding|cytoplasm|immune response|response to virus|response to bacterium IFI44L 94.361246 80.11186896 108.610623 1.355736977 0.439077312 0.362728175 1 0.725508774 0.967139874 10964 interferon induced protein 44 like "GO:0003674,GO:0005525,GO:0005575,GO:0005737,GO:0006955,GO:0051607" molecular_function|GTP binding|cellular_component|cytoplasm|immune response|defense response to virus IFI6 116.7056068 86.35435226 147.0568613 1.702946724 0.768033301 0.0836624 1 5.492935718 9.197647403 2537 interferon alpha inducible protein 6 "GO:0001836,GO:0005515,GO:0005739,GO:0005743,GO:0005886,GO:0006915,GO:0006955,GO:0016021,GO:0031966,GO:0042058,GO:0043066,GO:0043154,GO:0045087,GO:0051607,GO:0051902,GO:0060337,GO:0072593,GO:0097190,GO:0097193,GO:0098586,GO:2001240" release of cytochrome c from mitochondria|protein binding|mitochondrion|mitochondrial inner membrane|plasma membrane|apoptotic process|immune response|integral component of membrane|mitochondrial membrane|regulation of epidermal growth factor receptor signaling pathway|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|innate immune response|defense response to virus|negative regulation of mitochondrial depolarization|type I interferon signaling pathway|reactive oxygen species metabolic process|apoptotic signaling pathway|intrinsic apoptotic signaling pathway|cellular response to virus|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IFIH1 251.4744175 268.4267817 234.5220533 0.873690962 -0.194805028 0.565910655 1 4.000403237 3.436630119 64135 interferon induced with helicase C domain 1 "GO:0003677,GO:0003724,GO:0003725,GO:0003727,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0008270,GO:0009597,GO:0009615,GO:0016032,GO:0016579,GO:0016925,GO:0032480,GO:0032727,GO:0032728,GO:0032755,GO:0032760,GO:0034344,GO:0039528,GO:0039530,GO:0042802,GO:0043021,GO:0045087,GO:0051607,GO:0060760,GO:0071360" DNA binding|RNA helicase activity|double-stranded RNA binding|single-stranded RNA binding|protein binding|ATP binding|nucleus|cytoplasm|cytosol|zinc ion binding|detection of virus|response to virus|viral process|protein deubiquitination|protein sumoylation|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|regulation of type III interferon production|cytoplasmic pattern recognition receptor signaling pathway in response to virus|MDA-5 signaling pathway|identical protein binding|ribonucleoprotein complex binding|innate immune response|defense response to virus|positive regulation of response to cytokine stimulus|cellular response to exogenous dsRNA "hsa04622,hsa05161,hsa05162,hsa05164,hsa05168,hsa05171" RIG-I-like receptor signaling pathway|Hepatitis B|Measles|Influenza A|Herpes simplex virus 1 infection|Coronavirus disease - COVID-19 IFIT1 388.1611241 362.0640312 414.258217 1.144157335 0.194285453 0.508950507 1 4.281562574 4.816806756 3434 interferon induced protein with tetratricopeptide repeats 1 "GO:0003723,GO:0005515,GO:0005737,GO:0005829,GO:0009615,GO:0016032,GO:0019060,GO:0032091,GO:0043657,GO:0045070,GO:0045071,GO:0050688,GO:0051097,GO:0051607,GO:0060337,GO:0071357,GO:0071360" RNA binding|protein binding|cytoplasm|cytosol|response to virus|viral process|intracellular transport of viral protein in host cell|negative regulation of protein binding|host cell|positive regulation of viral genome replication|negative regulation of viral genome replication|regulation of defense response to virus|negative regulation of helicase activity|defense response to virus|type I interferon signaling pathway|cellular response to type I interferon|cellular response to exogenous dsRNA hsa05160 Hepatitis C IFIT2 503.0381537 513.964458 492.1118495 0.957482257 -0.062682341 0.824890818 1 8.084096227 7.610853949 3433 interferon induced protein with tetratricopeptide repeats 2 "GO:0003723,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0008637,GO:0009615,GO:0032091,GO:0035457,GO:0043065,GO:0051607,GO:0060337" RNA binding|protein binding|cytoplasm|endoplasmic reticulum|cytosol|apoptotic mitochondrial changes|response to virus|negative regulation of protein binding|cellular response to interferon-alpha|positive regulation of apoptotic process|defense response to virus|type I interferon signaling pathway IFIT3 711.3297503 809.4420007 613.2174999 0.75758053 -0.400528841 0.116954753 1 16.54478433 12.32426686 3437 interferon induced protein with tetratricopeptide repeats 3 "GO:0003674,GO:0003723,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0008285,GO:0009615,GO:0035457,GO:0042802,GO:0043066,GO:0051607,GO:0060337" molecular_function|RNA binding|protein binding|cytoplasm|mitochondrion|cytosol|negative regulation of cell population proliferation|response to virus|cellular response to interferon-alpha|identical protein binding|negative regulation of apoptotic process|defense response to virus|type I interferon signaling pathway IFIT5 951.1916528 974.867808 927.5154975 0.951426942 -0.071835215 0.774572388 1 12.91310578 12.08028924 24138 interferon induced protein with tetratricopeptide repeats 5 "GO:0000049,GO:0000339,GO:0003690,GO:0003723,GO:0003727,GO:0005515,GO:0005829,GO:0005886,GO:0008266,GO:0008385,GO:0015629,GO:0032587,GO:0043123,GO:0045071,GO:0045087,GO:0045177,GO:0051607" tRNA binding|RNA cap binding|double-stranded DNA binding|RNA binding|single-stranded RNA binding|protein binding|cytosol|plasma membrane|poly(U) RNA binding|IkappaB kinase complex|actin cytoskeleton|ruffle membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of viral genome replication|innate immune response|apical part of cell|defense response to virus IFITM1 33.50648032 34.33365813 32.6793025 0.951815341 -0.071246388 0.965552154 1 2.743000347 2.567141108 8519 interferon induced transmembrane protein 1 "GO:0001503,GO:0005515,GO:0005886,GO:0007166,GO:0008285,GO:0009615,GO:0016020,GO:0016021,GO:0030336,GO:0032991,GO:0034341,GO:0035455,GO:0035456,GO:0045071,GO:0045669,GO:0046597,GO:0050776,GO:0051607,GO:0060337" ossification|protein binding|plasma membrane|cell surface receptor signaling pathway|negative regulation of cell population proliferation|response to virus|membrane|integral component of membrane|negative regulation of cell migration|protein-containing complex|response to interferon-gamma|response to interferon-alpha|response to interferon-beta|negative regulation of viral genome replication|positive regulation of osteoblast differentiation|negative regulation of viral entry into host cell|regulation of immune response|defense response to virus|type I interferon signaling pathway hsa04662 B cell receptor signaling pathway IFITM10 4.964295633 4.161655531 5.766935736 1.385731158 0.470647391 0.897151737 1 0.059800729 0.081481054 402778 interferon induced transmembrane protein 10 "GO:0005886,GO:0016021" plasma membrane|integral component of membrane IFITM2 380.7889082 370.3873422 391.1904741 1.056165882 0.078836443 0.795741235 1 19.64899772 20.40533434 10581 interferon induced transmembrane protein 2 "GO:0005886,GO:0006955,GO:0009615,GO:0016021,GO:0032991,GO:0034341,GO:0035455,GO:0035456,GO:0045071,GO:0046597,GO:0051607,GO:0060337" plasma membrane|immune response|response to virus|integral component of membrane|protein-containing complex|response to interferon-gamma|response to interferon-alpha|response to interferon-beta|negative regulation of viral genome replication|negative regulation of viral entry into host cell|defense response to virus|type I interferon signaling pathway IFITM3 2581.491637 2417.921863 2745.06141 1.135297816 0.183070801 0.439062164 1 211.1948378 235.7568279 10410 interferon induced transmembrane protein 3 "GO:0005515,GO:0005765,GO:0005886,GO:0006955,GO:0009615,GO:0016021,GO:0031902,GO:0032897,GO:0032991,GO:0034341,GO:0035455,GO:0035456,GO:0045071,GO:0046597,GO:0048471,GO:0051607,GO:0060337" protein binding|lysosomal membrane|plasma membrane|immune response|response to virus|integral component of membrane|late endosome membrane|negative regulation of viral transcription|protein-containing complex|response to interferon-gamma|response to interferon-alpha|response to interferon-beta|negative regulation of viral genome replication|negative regulation of viral entry into host cell|perinuclear region of cytoplasm|defense response to virus|type I interferon signaling pathway IFNAR1 1039.677137 1026.888502 1052.465772 1.024907543 0.03549377 0.888693541 1 8.639941986 8.70696291 3454 interferon alpha and beta receptor subunit 1 "GO:0004896,GO:0004905,GO:0005515,GO:0005764,GO:0005770,GO:0005886,GO:0005887,GO:0007259,GO:0009615,GO:0016021,GO:0019221,GO:0019962,GO:0032496,GO:0035457,GO:0060337" cytokine receptor activity|type I interferon receptor activity|protein binding|lysosome|late endosome|plasma membrane|integral component of plasma membrane|receptor signaling pathway via JAK-STAT|response to virus|integral component of membrane|cytokine-mediated signaling pathway|type I interferon binding|response to lipopolysaccharide|cellular response to interferon-alpha|type I interferon signaling pathway "hsa04060,hsa04151,hsa04217,hsa04380,hsa04620,hsa04621,hsa04630,hsa04650,hsa05160,hsa05161,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05171,hsa05200" Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Necroptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|Hepatitis C|Hepatitis B|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Pathways in cancer IFNAR2 890.7683897 852.0989699 929.4378094 1.090762743 0.125337328 0.616664327 1 10.5608351 11.32660448 3455 interferon alpha and beta receptor subunit 2 "GO:0004896,GO:0004905,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0007166,GO:0007259,GO:0009615,GO:0016021,GO:0019221,GO:0019901,GO:0035455,GO:0035456,GO:0051607,GO:0060337,GO:0060338" cytokine receptor activity|type I interferon receptor activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|receptor signaling pathway via JAK-STAT|response to virus|integral component of membrane|cytokine-mediated signaling pathway|protein kinase binding|response to interferon-alpha|response to interferon-beta|defense response to virus|type I interferon signaling pathway|regulation of type I interferon-mediated signaling pathway "hsa04060,hsa04151,hsa04217,hsa04380,hsa04620,hsa04621,hsa04630,hsa04650,hsa05160,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05171,hsa05200" Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Necroptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|Hepatitis C|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Pathways in cancer IFNE 10.77086033 5.202069413 16.33965125 3.140990624 1.651219636 0.150233864 1 0.18822026 0.581305173 338376 interferon epsilon "GO:0002250,GO:0002286,GO:0002323,GO:0005125,GO:0005132,GO:0005615,GO:0006959,GO:0019221,GO:0030183,GO:0033141,GO:0042100,GO:0042742,GO:0043330,GO:0051607" adaptive immune response|T cell activation involved in immune response|natural killer cell activation involved in immune response|cytokine activity|type I interferon receptor binding|extracellular space|humoral immune response|cytokine-mediated signaling pathway|B cell differentiation|positive regulation of peptidyl-serine phosphorylation of STAT protein|B cell proliferation|defense response to bacterium|response to exogenous dsRNA|defense response to virus "hsa04060,hsa04622,hsa04630" Cytokine-cytokine receptor interaction|RIG-I-like receptor signaling pathway|JAK-STAT signaling pathway IFNGR1 573.9649353 609.6825352 538.2473354 0.882832137 -0.179788947 0.500365298 1 12.00207907 10.41851439 3459 interferon gamma receptor 1 "GO:0001774,GO:0004896,GO:0004906,GO:0005515,GO:0005886,GO:0005887,GO:0007165,GO:0009615,GO:0010628,GO:0016021,GO:0019221,GO:0019955,GO:0032760,GO:0048143,GO:0060333,GO:0060334,GO:1900222,GO:1902004" microglial cell activation|cytokine receptor activity|interferon-gamma receptor activity|protein binding|plasma membrane|integral component of plasma membrane|signal transduction|response to virus|positive regulation of gene expression|integral component of membrane|cytokine-mediated signaling pathway|cytokine binding|positive regulation of tumor necrosis factor production|astrocyte activation|interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|negative regulation of amyloid-beta clearance|positive regulation of amyloid-beta formation "hsa04060,hsa04066,hsa04217,hsa04380,hsa04630,hsa04650,hsa04658,hsa04659,hsa05140,hsa05142,hsa05145,hsa05152,hsa05164,hsa05167,hsa05168,hsa05200,hsa05235,hsa05321" Cytokine-cytokine receptor interaction|HIF-1 signaling pathway|Necroptosis|Osteoclast differentiation|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Pathways in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease IFNGR2 2735.910039 2535.488632 2936.331446 1.158092925 0.211751019 0.370811928 1 59.16675481 67.37400068 3460 interferon gamma receptor 2 "GO:0000139,GO:0004896,GO:0004906,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0007166,GO:0009615,GO:0016021,GO:0019221,GO:0030659,GO:0060333,GO:0060334" Golgi membrane|cytokine receptor activity|interferon-gamma receptor activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|response to virus|integral component of membrane|cytokine-mediated signaling pathway|cytoplasmic vesicle membrane|interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway "hsa04060,hsa04066,hsa04217,hsa04380,hsa04630,hsa04650,hsa04658,hsa04659,hsa05140,hsa05142,hsa05145,hsa05152,hsa05164,hsa05168,hsa05200,hsa05235,hsa05321" Cytokine-cytokine receptor interaction|HIF-1 signaling pathway|Necroptosis|Osteoclast differentiation|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Influenza A|Herpes simplex virus 1 infection|Pathways in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease IFNLR1 96.68487796 78.0310412 115.3387147 1.478113235 0.563756795 0.235757252 1 0.818147987 1.189079113 163702 interferon lambda receptor 1 "GO:0002385,GO:0004896,GO:0005515,GO:0005886,GO:0008285,GO:0016021,GO:0019221,GO:0032002,GO:0034342,GO:0050691,GO:0051607" mucosal immune response|cytokine receptor activity|protein binding|plasma membrane|negative regulation of cell population proliferation|integral component of membrane|cytokine-mediated signaling pathway|interleukin-28 receptor complex|response to type III interferon|regulation of defense response to virus by host|defense response to virus "hsa04060,hsa04630" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway IFRD1 1445.994585 1651.136832 1240.852339 0.751513936 -0.412128237 0.084745745 1 22.12911553 16.35205252 3475 interferon related developmental regulator 1 "GO:0005634,GO:0006357,GO:0007275,GO:0007518" nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|myoblast fate determination IFRD2 991.0249047 1011.282294 970.7675156 0.959937222 -0.058988036 0.814066565 1 27.77677682 26.21777668 7866 interferon related developmental regulator 2 "GO:0003674,GO:0005515,GO:0005634" molecular_function|protein binding|nucleus IFT122 374.7345088 388.0743782 361.3946395 0.931250966 -0.102758078 0.734002467 1 3.290565033 3.013064253 55764 intraflagellar transport 122 "GO:0001843,GO:0005515,GO:0005737,GO:0005929,GO:0010172,GO:0016020,GO:0030991,GO:0032391,GO:0035050,GO:0035721,GO:0035735,GO:0036064,GO:0042073,GO:0045879,GO:0048593,GO:0060173,GO:0060271,GO:0061512,GO:0097542,GO:0097730,GO:1905515" neural tube closure|protein binding|cytoplasm|cilium|embryonic body morphogenesis|membrane|intraciliary transport particle A|photoreceptor connecting cilium|embryonic heart tube development|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|negative regulation of smoothened signaling pathway|camera-type eye morphogenesis|limb development|cilium assembly|protein localization to cilium|ciliary tip|non-motile cilium|non-motile cilium assembly IFT140 436.7284536 488.9945248 384.4623824 0.786230444 -0.346975867 0.219616175 1 2.012239884 1.55561022 9742 intraflagellar transport 140 "GO:0001750,GO:0003674,GO:0005515,GO:0005813,GO:0005814,GO:0005929,GO:0005930,GO:0007368,GO:0007507,GO:0008589,GO:0021532,GO:0030991,GO:0031076,GO:0032391,GO:0035721,GO:0035735,GO:0035845,GO:0036064,GO:0042073,GO:0042733,GO:0048701,GO:0060271,GO:0061512,GO:0097542,GO:1902017,GO:1905515,GO:1990403" photoreceptor outer segment|molecular_function|protein binding|centrosome|centriole|cilium|axoneme|determination of left/right symmetry|heart development|regulation of smoothened signaling pathway|neural tube patterning|intraciliary transport particle A|embryonic camera-type eye development|photoreceptor connecting cilium|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|photoreceptor cell outer segment organization|ciliary basal body|intraciliary transport|embryonic digit morphogenesis|embryonic cranial skeleton morphogenesis|cilium assembly|protein localization to cilium|ciliary tip|regulation of cilium assembly|non-motile cilium assembly|embryonic brain development IFT172 342.2929801 394.3168615 290.2690987 0.736131591 -0.441964409 0.143562831 1 2.773687383 2.007632167 26160 intraflagellar transport 172 "GO:0001843,GO:0001947,GO:0005929,GO:0005930,GO:0007219,GO:0007224,GO:0007420,GO:0008544,GO:0009953,GO:0016485,GO:0021522,GO:0030992,GO:0031122,GO:0035735,GO:0036064,GO:0042073,GO:0045879,GO:0045880,GO:0048596,GO:0050680,GO:0060021,GO:0060173,GO:0060271,GO:0060348,GO:0061525,GO:0070986,GO:0097225,GO:0097228,GO:0097542,GO:0097598,GO:1903561,GO:1905515" neural tube closure|heart looping|cilium|axoneme|Notch signaling pathway|smoothened signaling pathway|brain development|epidermis development|dorsal/ventral pattern formation|protein processing|spinal cord motor neuron differentiation|intraciliary transport particle B|cytoplasmic microtubule organization|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway|embryonic camera-type eye morphogenesis|negative regulation of epithelial cell proliferation|roof of mouth development|limb development|cilium assembly|bone development|hindgut development|left/right axis specification|sperm midpiece|sperm principal piece|ciliary tip|sperm cytoplasmic droplet|extracellular vesicle|non-motile cilium assembly IFT20 291.3969882 281.9521622 300.8418142 1.066995947 0.093554696 0.777297622 1 12.38458328 12.99317675 90410 intraflagellar transport 20 "GO:0000139,GO:0001736,GO:0001750,GO:0001822,GO:0002046,GO:0005515,GO:0005794,GO:0005801,GO:0005813,GO:0005814,GO:0005902,GO:0005929,GO:0007224,GO:0007283,GO:0008542,GO:0030992,GO:0031267,GO:0031514,GO:0032391,GO:0032420,GO:0034067,GO:0035735,GO:0035845,GO:0036372,GO:0042073,GO:0044292,GO:0045198,GO:0051642,GO:0055007,GO:0060122,GO:0060271,GO:0060828,GO:0061351,GO:0061512,GO:0072659,GO:0090102,GO:0097542,GO:0097546,GO:1902017,GO:1902636,GO:2000583,GO:2000785" Golgi membrane|establishment of planar polarity|photoreceptor outer segment|kidney development|opsin binding|protein binding|Golgi apparatus|cis-Golgi network|centrosome|centriole|microvillus|cilium|smoothened signaling pathway|spermatogenesis|visual learning|intraciliary transport particle B|small GTPase binding|motile cilium|photoreceptor connecting cilium|stereocilium|protein localization to Golgi apparatus|intraciliary transport involved in cilium assembly|photoreceptor cell outer segment organization|opsin transport|intraciliary transport|dendrite terminus|establishment of epithelial cell apical/basal polarity|centrosome localization|cardiac muscle cell differentiation|inner ear receptor cell stereocilium organization|cilium assembly|regulation of canonical Wnt signaling pathway|neural precursor cell proliferation|protein localization to cilium|protein localization to plasma membrane|cochlea development|ciliary tip|ciliary base|regulation of cilium assembly|kinociliary basal body|regulation of platelet-derived growth factor receptor-alpha signaling pathway|regulation of autophagosome assembly IFT22 532.8836782 490.0349387 575.7324176 1.174880345 0.232513833 0.389828287 1 5.267324075 6.084919767 64792 intraflagellar transport 22 "GO:0003924,GO:0005525,GO:0005813,GO:0005929,GO:0006886,GO:0012505,GO:0030992,GO:0035735,GO:0097542" GTPase activity|GTP binding|centrosome|cilium|intracellular protein transport|endomembrane system|intraciliary transport particle B|intraciliary transport involved in cilium assembly|ciliary tip IFT27 78.10588309 69.70773014 86.50403604 1.240953275 0.311448796 0.553887632 1 1.485692268 1.812823288 11020 intraflagellar transport 27 "GO:0000139,GO:0001822,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005794,GO:0005813,GO:0005929,GO:0006886,GO:0007224,GO:0007283,GO:0030992,GO:0031514,GO:0035735,GO:0036126,GO:0042073,GO:0060122,GO:0090102,GO:0097225,GO:0097228,GO:0097542" Golgi membrane|kidney development|GTPase activity|protein binding|GTP binding|cytoplasm|Golgi apparatus|centrosome|cilium|intracellular protein transport|smoothened signaling pathway|spermatogenesis|intraciliary transport particle B|motile cilium|intraciliary transport involved in cilium assembly|sperm flagellum|intraciliary transport|inner ear receptor cell stereocilium organization|cochlea development|sperm midpiece|sperm principal piece|ciliary tip IFT43 409.573897 394.3168615 424.8309325 1.077384647 0.107533411 0.714510448 1 13.95488473 14.7831919 112752 intraflagellar transport 43 "GO:0005515,GO:0005737,GO:0005929,GO:0015630,GO:0030991,GO:0034451,GO:0035721,GO:0035735,GO:0060271,GO:0097542" protein binding|cytoplasm|cilium|microtubule cytoskeleton|intraciliary transport particle A|centriolar satellite|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|cilium assembly|ciliary tip IFT46 364.9644334 383.9127227 346.0161442 0.901288558 -0.14993902 0.618607901 1 3.669839944 3.252236799 56912 intraflagellar transport 46 "GO:0003674,GO:0005737,GO:0005813,GO:0005929,GO:0008022,GO:0008150,GO:0030992,GO:0031514,GO:0035735,GO:0036064,GO:0042073,GO:0050821,GO:0060271,GO:0097542" molecular_function|cytoplasm|centrosome|cilium|protein C-terminus binding|biological_process|intraciliary transport particle B|motile cilium|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|protein stabilization|cilium assembly|ciliary tip IFT52 827.2880516 762.623376 891.9527272 1.169584824 0.225996497 0.368175455 1 21.00093289 24.15135436 51098 intraflagellar transport 52 "GO:0001841,GO:0001947,GO:0005813,GO:0005814,GO:0005929,GO:0007224,GO:0008022,GO:0009953,GO:0030992,GO:0031514,GO:0032391,GO:0035720,GO:0035735,GO:0036064,GO:0042073,GO:0042733,GO:0044292,GO:0050680,GO:0060271,GO:0070613,GO:0097542,GO:0097546,GO:1905515" neural tube formation|heart looping|centrosome|centriole|cilium|smoothened signaling pathway|protein C-terminus binding|dorsal/ventral pattern formation|intraciliary transport particle B|motile cilium|photoreceptor connecting cilium|intraciliary anterograde transport|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|embryonic digit morphogenesis|dendrite terminus|negative regulation of epithelial cell proliferation|cilium assembly|regulation of protein processing|ciliary tip|ciliary base|non-motile cilium assembly IFT57 661.3754071 646.0970211 676.653793 1.047294401 0.066667051 0.80154761 1 11.2793623 11.61514156 55081 intraflagellar transport 57 "GO:0001843,GO:0001947,GO:0003677,GO:0005515,GO:0005794,GO:0005813,GO:0005929,GO:0005930,GO:0006915,GO:0006919,GO:0007224,GO:0030992,GO:0032391,GO:0035735,GO:0036064,GO:0042073,GO:0042981,GO:0044292,GO:0044458,GO:0050680,GO:0060972,GO:0097542,GO:1905515" neural tube closure|heart looping|DNA binding|protein binding|Golgi apparatus|centrosome|cilium|axoneme|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|smoothened signaling pathway|intraciliary transport particle B|photoreceptor connecting cilium|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|regulation of apoptotic process|dendrite terminus|motile cilium assembly|negative regulation of epithelial cell proliferation|left/right pattern formation|ciliary tip|non-motile cilium assembly "hsa05016,hsa05022" Huntington disease|Pathways of neurodegeneration - multiple diseases IFT74 371.3258036 399.5189309 343.1326763 0.858864624 -0.219497347 0.460182228 1 2.46207749 2.079206436 80173 intraflagellar transport 74 "GO:0003334,GO:0003682,GO:0005515,GO:0005634,GO:0005813,GO:0005929,GO:0007219,GO:0007368,GO:0007507,GO:0030992,GO:0031410,GO:0031514,GO:0033630,GO:0035735,GO:0045944,GO:0048487,GO:0050680,GO:0060271,GO:0097542,GO:1905515" keratinocyte development|chromatin binding|protein binding|nucleus|centrosome|cilium|Notch signaling pathway|determination of left/right symmetry|heart development|intraciliary transport particle B|cytoplasmic vesicle|motile cilium|positive regulation of cell adhesion mediated by integrin|intraciliary transport involved in cilium assembly|positive regulation of transcription by RNA polymerase II|beta-tubulin binding|negative regulation of epithelial cell proliferation|cilium assembly|ciliary tip|non-motile cilium assembly IFT80 947.1287625 1019.605605 874.65192 0.857833574 -0.221230314 0.371286697 1 12.14337808 10.24268307 57560 intraflagellar transport 80 "GO:0001649,GO:0001958,GO:0003418,GO:0005737,GO:0005813,GO:0005929,GO:0007224,GO:0030992,GO:0033687,GO:0035630,GO:0035735,GO:0036064,GO:0050680,GO:0060173,GO:0060271,GO:0061975,GO:0097500,GO:0097542,GO:0097731,GO:1905515,GO:2000051" osteoblast differentiation|endochondral ossification|growth plate cartilage chondrocyte differentiation|cytoplasm|centrosome|cilium|smoothened signaling pathway|intraciliary transport particle B|osteoblast proliferation|bone mineralization involved in bone maturation|intraciliary transport involved in cilium assembly|ciliary basal body|negative regulation of epithelial cell proliferation|limb development|cilium assembly|articular cartilage development|receptor localization to non-motile cilium|ciliary tip|9+0 non-motile cilium|non-motile cilium assembly|negative regulation of non-canonical Wnt signaling pathway IFT81 437.1203272 410.9634836 463.2771708 1.12729522 0.172865383 0.544363795 1 5.176390324 5.737673891 28981 intraflagellar transport 81 "GO:0005515,GO:0005813,GO:0005929,GO:0007283,GO:0008589,GO:0015631,GO:0030992,GO:0031514,GO:0035735,GO:0036064,GO:0042073,GO:0060271,GO:0097542" protein binding|centrosome|cilium|spermatogenesis|regulation of smoothened signaling pathway|tubulin binding|intraciliary transport particle B|motile cilium|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|cilium assembly|ciliary tip IFT88 340.1479857 350.6194785 329.6764929 0.940268619 -0.088855125 0.777254133 1 3.293771722 3.045205584 8100 intraflagellar transport 88 "GO:0001822,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0005929,GO:0019894,GO:0030992,GO:0031514,GO:0035735,GO:0036064,GO:0036126,GO:0042073,GO:0060122,GO:0060271,GO:0097542,GO:0097546,GO:0097730,GO:1902017,GO:1905515,GO:2000785" kidney development|protein binding|cytoplasm|centrosome|centriole|cilium|kinesin binding|intraciliary transport particle B|motile cilium|intraciliary transport involved in cilium assembly|ciliary basal body|sperm flagellum|intraciliary transport|inner ear receptor cell stereocilium organization|cilium assembly|ciliary tip|ciliary base|non-motile cilium|regulation of cilium assembly|non-motile cilium assembly|regulation of autophagosome assembly IFTAP 237.4388909 215.3656737 259.5121081 1.204983615 0.26901353 0.434203022 1 8.700734429 10.30880283 119710 intraflagellar transport associated protein "GO:0005515,GO:0005829,GO:0007283,GO:0007340,GO:0097731,GO:0120160" protein binding|cytosol|spermatogenesis|acrosome reaction|9+0 non-motile cilium|intraciliary transport particle A binding IGBP1 2414.909102 2473.063799 2356.754404 0.952969513 -0.069498034 0.77003253 1 70.80626055 66.34708467 3476 immunoglobulin binding protein 1 "GO:0000122,GO:0005515,GO:0005737,GO:0005829,GO:0007165,GO:0019888,GO:0032873,GO:0034612,GO:0035303,GO:0042113,GO:0043154,GO:0043666,GO:0051721,GO:0060632,GO:0070555" negative regulation of transcription by RNA polymerase II|protein binding|cytoplasm|cytosol|signal transduction|protein phosphatase regulator activity|negative regulation of stress-activated MAPK cascade|response to tumor necrosis factor|regulation of dephosphorylation|B cell activation|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of phosphoprotein phosphatase activity|protein phosphatase 2A binding|regulation of microtubule-based movement|response to interleukin-1 "hsa04136,hsa04140" Autophagy - other|Autophagy - animal IGDCC4 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.007938944 0.028845738 57722 immunoglobulin superfamily DCC subclass member 4 "GO:0005886,GO:0016021" plasma membrane|integral component of membrane IGF1R 604.0973089 668.9861265 539.2084913 0.80600848 -0.311133077 0.236356933 1 2.663773784 2.111096717 3480 insulin like growth factor 1 receptor "GO:0004713,GO:0004714,GO:0005009,GO:0005010,GO:0005158,GO:0005515,GO:0005520,GO:0005524,GO:0005886,GO:0005887,GO:0005899,GO:0006955,GO:0007165,GO:0007169,GO:0007275,GO:0008284,GO:0008286,GO:0014065,GO:0014068,GO:0016020,GO:0016032,GO:0030335,GO:0030424,GO:0031994,GO:0033674,GO:0035867,GO:0038083,GO:0042593,GO:0042802,GO:0043066,GO:0043231,GO:0043235,GO:0043243,GO:0043410,GO:0043548,GO:0043559,GO:0043560,GO:0045056,GO:0046328,GO:0046777,GO:0048009,GO:0048015,GO:0051389,GO:0051897,GO:0071333,GO:0097062,GO:0097242,GO:0120162,GO:0140318,GO:1902911,GO:1904646" protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|insulin-activated receptor activity|insulin-like growth factor-activated receptor activity|insulin receptor binding|protein binding|insulin-like growth factor binding|ATP binding|plasma membrane|integral component of plasma membrane|insulin receptor complex|immune response|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|positive regulation of cell population proliferation|insulin receptor signaling pathway|phosphatidylinositol 3-kinase signaling|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|viral process|positive regulation of cell migration|axon|insulin-like growth factor I binding|positive regulation of kinase activity|alphav-beta3 integrin-IGF-1-IGF1R complex|peptidyl-tyrosine autophosphorylation|glucose homeostasis|identical protein binding|negative regulation of apoptotic process|intracellular membrane-bounded organelle|receptor complex|positive regulation of protein-containing complex disassembly|positive regulation of MAPK cascade|phosphatidylinositol 3-kinase binding|insulin binding|insulin receptor substrate binding|transcytosis|regulation of JNK cascade|protein autophosphorylation|insulin-like growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|inactivation of MAPKK activity|positive regulation of protein kinase B signaling|cellular response to glucose stimulus|dendritic spine maintenance|amyloid-beta clearance|positive regulation of cold-induced thermogenesis|protein transporter activity|protein kinase complex|cellular response to amyloid-beta "hsa01521,hsa01522,hsa04010,hsa04014,hsa04015,hsa04066,hsa04068,hsa04114,hsa04140,hsa04144,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04510,hsa04520,hsa04550,hsa04730,hsa04913,hsa04914,hsa05200,hsa05202,hsa05205,hsa05214,hsa05215,hsa05218,hsa05224,hsa05225" EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Oocyte meiosis|Autophagy - animal|Endocytosis|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Focal adhesion|Adherens junction|Signaling pathways regulating pluripotency of stem cells|Long-term depression|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Pathways in cancer|Transcriptional misregulation in cancer|Proteoglycans in cancer|Glioma|Prostate cancer|Melanoma|Breast cancer|Hepatocellular carcinoma IGF2 22.78027936 17.687036 27.87352272 1.575929552 0.656203044 0.433950845 1 0.142759317 0.221213914 3481 insulin like growth factor 2 "GO:0000122,GO:0001501,GO:0001649,GO:0001701,GO:0001892,GO:0001934,GO:0002576,GO:0005158,GO:0005159,GO:0005178,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0006006,GO:0006349,GO:0006355,GO:0007275,GO:0008083,GO:0008284,GO:0008286,GO:0009887,GO:0031017,GO:0031056,GO:0031093,GO:0038028,GO:0040018,GO:0042104,GO:0043085,GO:0043410,GO:0043539,GO:0044267,GO:0045725,GO:0045840,GO:0045944,GO:0046622,GO:0046628,GO:0048018,GO:0048633,GO:0050731,GO:0051146,GO:0051147,GO:0051148,GO:0051781,GO:0051897,GO:0060669,GO:0071902,GO:1905564,GO:2000467" "negative regulation of transcription by RNA polymerase II|skeletal system development|osteoblast differentiation|in utero embryonic development|embryonic placenta development|positive regulation of protein phosphorylation|platelet degranulation|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding|hormone activity|protein binding|extracellular region|extracellular space|glucose metabolic process|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-templated|multicellular organism development|growth factor activity|positive regulation of cell population proliferation|insulin receptor signaling pathway|animal organ morphogenesis|exocrine pancreas development|regulation of histone modification|platelet alpha granule lumen|insulin receptor signaling pathway via phosphatidylinositol 3-kinase|positive regulation of multicellular organism growth|positive regulation of activated T cell proliferation|positive regulation of catalytic activity|positive regulation of MAPK cascade|protein serine/threonine kinase activator activity|cellular protein metabolic process|positive regulation of glycogen biosynthetic process|positive regulation of mitotic nuclear division|positive regulation of transcription by RNA polymerase II|positive regulation of organ growth|positive regulation of insulin receptor signaling pathway|receptor ligand activity|positive regulation of skeletal muscle tissue growth|positive regulation of peptidyl-tyrosine phosphorylation|striated muscle cell differentiation|regulation of muscle cell differentiation|negative regulation of muscle cell differentiation|positive regulation of cell division|positive regulation of protein kinase B signaling|embryonic placenta morphogenesis|positive regulation of protein serine/threonine kinase activity|positive regulation of vascular endothelial cell proliferation|positive regulation of glycogen (starch) synthase activity" "hsa04010,hsa04014,hsa04151,hsa05200,hsa05205,hsa05225" MAPK signaling pathway|Ras signaling pathway|PI3K-Akt signaling pathway|Pathways in cancer|Proteoglycans in cancer|Hepatocellular carcinoma IGF2BP1 1114.413944 1109.081199 1119.746689 1.009616509 0.013807407 0.958830922 1 6.512226337 6.464829992 10642 insulin like growth factor 2 mRNA binding protein 1 "GO:0001817,GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007399,GO:0010468,GO:0010494,GO:0010610,GO:0017148,GO:0022013,GO:0030027,GO:0030175,GO:0030426,GO:0043197,GO:0043488,GO:0045182,GO:0048027,GO:0048471,GO:0051028,GO:0051252,GO:0070934,GO:0070937,GO:0097150,GO:1990904" regulation of cytokine production|RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|nervous system development|regulation of gene expression|cytoplasmic stress granule|regulation of mRNA stability involved in response to stress|negative regulation of translation|pallium cell proliferation in forebrain|lamellipodium|filopodium|growth cone|dendritic spine|regulation of mRNA stability|translation regulator activity|mRNA 5'-UTR binding|perinuclear region of cytoplasm|mRNA transport|regulation of RNA metabolic process|CRD-mediated mRNA stabilization|CRD-mediated mRNA stability complex|neuronal stem cell population maintenance|ribonucleoprotein complex hsa05206 MicroRNAs in cancer IGF2BP2 2859.767137 3061.938057 2657.596218 0.867945781 -0.204323172 0.387985652 1 24.4442792 20.86128281 10644 insulin like growth factor 2 mRNA binding protein 2 "GO:0001817,GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0007399,GO:0009653,GO:0010468,GO:0017148,GO:0043488,GO:0045182,GO:0048027,GO:0051028,GO:0051252" regulation of cytokine production|RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|cytosol|cytoskeleton|nervous system development|anatomical structure morphogenesis|regulation of gene expression|negative regulation of translation|regulation of mRNA stability|translation regulator activity|mRNA 5'-UTR binding|mRNA transport|regulation of RNA metabolic process IGF2BP3 1520.454604 1625.126485 1415.782723 0.871183097 -0.198952133 0.404662491 1 19.74727086 16.9156115 10643 insulin like growth factor 2 mRNA binding protein 3 "GO:0001817,GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006412,GO:0007399,GO:0009653,GO:0010468,GO:0017148,GO:0043488,GO:0045182,GO:0048027,GO:0051028,GO:0051252" regulation of cytokine production|RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|cytosol|translation|nervous system development|anatomical structure morphogenesis|regulation of gene expression|negative regulation of translation|regulation of mRNA stability|translation regulator activity|mRNA 5'-UTR binding|mRNA transport|regulation of RNA metabolic process IGF2R 4759.823125 5619.27538 3900.370869 0.694105664 -0.526772793 0.028144855 0.877967194 21.32781447 14.556036 3482 insulin like growth factor 2 receptor "GO:0001889,GO:0001965,GO:0001972,GO:0005010,GO:0005515,GO:0005520,GO:0005537,GO:0005641,GO:0005768,GO:0005769,GO:0005770,GO:0005794,GO:0005802,GO:0005886,GO:0005887,GO:0005925,GO:0006898,GO:0007041,GO:0007165,GO:0007186,GO:0007283,GO:0009791,GO:0009986,GO:0010008,GO:0016020,GO:0019899,GO:0030118,GO:0030133,GO:0030139,GO:0030140,GO:0030665,GO:0030667,GO:0031100,GO:0031995,GO:0032526,GO:0032588,GO:0038023,GO:0042802,GO:0043065,GO:0043312,GO:0044794,GO:0048009,GO:0048471,GO:0051219,GO:0061024,GO:0070062,GO:1904772,GO:1905394" liver development|G-protein alpha-subunit binding|retinoic acid binding|insulin-like growth factor-activated receptor activity|protein binding|insulin-like growth factor binding|mannose binding|nuclear envelope lumen|endosome|early endosome|late endosome|Golgi apparatus|trans-Golgi network|plasma membrane|integral component of plasma membrane|focal adhesion|receptor-mediated endocytosis|lysosomal transport|signal transduction|G protein-coupled receptor signaling pathway|spermatogenesis|post-embryonic development|cell surface|endosome membrane|membrane|enzyme binding|clathrin coat|transport vesicle|endocytic vesicle|trans-Golgi network transport vesicle|clathrin-coated vesicle membrane|secretory granule membrane|animal organ regeneration|insulin-like growth factor II binding|response to retinoic acid|trans-Golgi network membrane|signaling receptor activity|identical protein binding|positive regulation of apoptotic process|neutrophil degranulation|positive regulation by host of viral process|insulin-like growth factor receptor signaling pathway|perinuclear region of cytoplasm|phosphoprotein binding|membrane organization|extracellular exosome|response to tetrachloromethane|retromer complex binding "hsa04142,hsa04144" Lysosome|Endocytosis IGFBP1 35.63196746 27.05076095 44.21317398 1.634452135 0.708807128 0.303960202 1 0.953533286 1.532425052 3484 insulin like growth factor binding protein 1 "GO:0005102,GO:0005515,GO:0005520,GO:0005576,GO:0005615,GO:0005788,GO:0005794,GO:0007165,GO:0007568,GO:0008286,GO:0030307,GO:0031994,GO:0031995,GO:0036499,GO:0042246,GO:0043567,GO:0043687,GO:0044267,GO:0090090" signaling receptor binding|protein binding|insulin-like growth factor binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|signal transduction|aging|insulin receptor signaling pathway|positive regulation of cell growth|insulin-like growth factor I binding|insulin-like growth factor II binding|PERK-mediated unfolded protein response|tissue regeneration|regulation of insulin-like growth factor receptor signaling pathway|post-translational protein modification|cellular protein metabolic process|negative regulation of canonical Wnt signaling pathway IGFBP3 2436.425555 1751.016564 3121.834545 1.782869796 0.834201346 0.000448595 0.113602452 35.51825763 62.26478017 3486 insulin like growth factor binding protein 3 "GO:0001558,GO:0001649,GO:0001933,GO:0001968,GO:0005515,GO:0005520,GO:0005576,GO:0005615,GO:0005634,GO:0005788,GO:0006468,GO:0006915,GO:0008160,GO:0008285,GO:0009968,GO:0010906,GO:0014912,GO:0016942,GO:0031994,GO:0031995,GO:0042567,GO:0042981,GO:0043065,GO:0043410,GO:0043567,GO:0043568,GO:0043666,GO:0043687,GO:0044267,GO:0044342,GO:0045663,GO:0046872,GO:0048662" regulation of cell growth|osteoblast differentiation|negative regulation of protein phosphorylation|fibronectin binding|protein binding|insulin-like growth factor binding|extracellular region|extracellular space|nucleus|endoplasmic reticulum lumen|protein phosphorylation|apoptotic process|protein tyrosine phosphatase activator activity|negative regulation of cell population proliferation|negative regulation of signal transduction|regulation of glucose metabolic process|negative regulation of smooth muscle cell migration|insulin-like growth factor binding protein complex|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor ternary complex|regulation of apoptotic process|positive regulation of apoptotic process|positive regulation of MAPK cascade|regulation of insulin-like growth factor receptor signaling pathway|positive regulation of insulin-like growth factor receptor signaling pathway|regulation of phosphoprotein phosphatase activity|post-translational protein modification|cellular protein metabolic process|type B pancreatic cell proliferation|positive regulation of myoblast differentiation|metal ion binding|negative regulation of smooth muscle cell proliferation "hsa04115,hsa04218,hsa04935,hsa05202" "p53 signaling pathway|Cellular senescence|Growth hormone synthesis, secretion and action|Transcriptional misregulation in cancer" IGFBP4 2642.936421 2390.871102 2895.001739 1.210856468 0.276027862 0.243142125 1 57.86684648 68.89594483 3487 insulin like growth factor binding protein 4 "GO:0001558,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0006954,GO:0007165,GO:0010906,GO:0031994,GO:0031995,GO:0043410,GO:0043567,GO:0043568,GO:0043687,GO:0044267,GO:0044342,GO:0090090" regulation of cell growth|signaling receptor binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|inflammatory response|signal transduction|regulation of glucose metabolic process|insulin-like growth factor I binding|insulin-like growth factor II binding|positive regulation of MAPK cascade|regulation of insulin-like growth factor receptor signaling pathway|positive regulation of insulin-like growth factor receptor signaling pathway|post-translational protein modification|cellular protein metabolic process|type B pancreatic cell proliferation|negative regulation of canonical Wnt signaling pathway IGFBP6 1395.859032 1142.374443 1649.34362 1.443785468 0.529856389 0.027139968 0.873268385 64.37848409 91.39334886 3489 insulin like growth factor binding protein 6 "GO:0000187,GO:0001968,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005794,GO:0007165,GO:0008285,GO:0016477,GO:0031994,GO:0031995,GO:0042568,GO:0042802,GO:0043567,GO:0044267,GO:0090090" activation of MAPK activity|fibronectin binding|signaling receptor binding|protein binding|extracellular region|extracellular space|Golgi apparatus|signal transduction|negative regulation of cell population proliferation|cell migration|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor binary complex|identical protein binding|regulation of insulin-like growth factor receptor signaling pathway|cellular protein metabolic process|negative regulation of canonical Wnt signaling pathway IGFBP7 3084.266865 2988.068671 3180.465058 1.064388208 0.090024433 0.704674503 1 100.0424926 104.702183 3490 insulin like growth factor binding protein 7 "GO:0001558,GO:0005201,GO:0005515,GO:0005520,GO:0005576,GO:0005615,GO:0005788,GO:0007155,GO:0007566,GO:0008285,GO:0009408,GO:0009966,GO:0032526,GO:0032870,GO:0043687,GO:0044267,GO:0050810,GO:0051414,GO:0062023,GO:0070062" regulation of cell growth|extracellular matrix structural constituent|protein binding|insulin-like growth factor binding|extracellular region|extracellular space|endoplasmic reticulum lumen|cell adhesion|embryo implantation|negative regulation of cell population proliferation|response to heat|regulation of signal transduction|response to retinoic acid|cellular response to hormone stimulus|post-translational protein modification|cellular protein metabolic process|regulation of steroid biosynthetic process|response to cortisol|collagen-containing extracellular matrix|extracellular exosome IGFLR1 42.47391563 42.65696919 42.29086206 0.991417414 -0.012435496 1 1 1.707819989 1.664829695 79713 IGF like family receptor 1 "GO:0005515,GO:0005886,GO:0016021" protein binding|plasma membrane|integral component of membrane IGFN1 10624.15564 13273.60031 7974.710967 0.600794869 -0.735055602 0.003790495 0.381096168 58.95369948 34.82638984 91156 immunoglobulin like and fibronectin type III domain containing 1 "GO:0005515,GO:0005634,GO:0007156,GO:0007416,GO:0008150,GO:0010842,GO:0030018,GO:0045202" protein binding|nucleus|homophilic cell adhesion via plasma membrane adhesion molecules|synapse assembly|biological_process|retina layer formation|Z disc|synapse IGHMBP2 431.0162381 452.5800389 409.4524373 0.904707239 -0.14447708 0.614925883 1 3.407161077 3.030902106 3508 immunoglobulin mu DNA binding protein 2 "GO:0000049,GO:0003677,GO:0003678,GO:0003697,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006260,GO:0006281,GO:0006310,GO:0006412,GO:0008094,GO:0008134,GO:0008186,GO:0008270,GO:0016020,GO:0016604,GO:0030424,GO:0030426,GO:0032508,GO:0032574,GO:0042802,GO:0043022,GO:0043139,GO:1990904" tRNA binding|DNA binding|DNA helicase activity|single-stranded DNA binding|RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|DNA replication|DNA repair|DNA recombination|translation|DNA-dependent ATPase activity|transcription factor binding|RNA-dependent ATPase activity|zinc ion binding|membrane|nuclear body|axon|growth cone|DNA duplex unwinding|5'-3' RNA helicase activity|identical protein binding|ribosome binding|5'-3' DNA helicase activity|ribonucleoprotein complex IGIP 251.0189916 206.0019488 296.0360344 1.437054534 0.523114811 0.118036651 1 3.181118458 4.494943833 492311 IgA inducing protein GO:0005576 extracellular region IGLL1 12.16793489 16.64662212 7.689247648 0.461910386 -1.11431511 0.300886484 1 1.002708383 0.455411037 3543 immunoglobulin lambda like polypeptide 1 "GO:0003823,GO:0005515,GO:0005576,GO:0005783,GO:0006910,GO:0006911,GO:0006955,GO:0006958,GO:0009897,GO:0016020,GO:0034987,GO:0042571,GO:0042742,GO:0045087,GO:0050853,GO:0050871,GO:0050900" "antigen binding|protein binding|extracellular region|endoplasmic reticulum|phagocytosis, recognition|phagocytosis, engulfment|immune response|complement activation, classical pathway|external side of plasma membrane|membrane|immunoglobulin receptor binding|immunoglobulin complex, circulating|defense response to bacterium|innate immune response|B cell receptor signaling pathway|positive regulation of B cell activation|leukocyte migration" hsa05340 Primary immunodeficiency IGSF10 789.242519 861.4626948 717.0223432 0.832331275 -0.264770247 0.293925831 1 4.409618331 3.608846363 285313 immunoglobulin superfamily member 10 "GO:0001503,GO:0005576,GO:0007275,GO:0030154,GO:2001222" ossification|extracellular region|multicellular organism development|cell differentiation|regulation of neuron migration IGSF11 5.524131538 6.242483296 4.80577978 0.769850643 -0.377349516 0.927604977 1 0.077929792 0.058990377 152404 immunoglobulin superfamily member 11 "GO:0005515,GO:0005886,GO:0005911,GO:0007156,GO:0014069,GO:0016021,GO:0035255,GO:0040008,GO:0045185,GO:0060076,GO:0061885,GO:1900273" protein binding|plasma membrane|cell-cell junction|homophilic cell adhesion via plasma membrane adhesion molecules|postsynaptic density|integral component of membrane|ionotropic glutamate receptor binding|regulation of growth|maintenance of protein location|excitatory synapse|positive regulation of mini excitatory postsynaptic potential|positive regulation of long-term synaptic potentiation hsa04514 Cell adhesion molecules IGSF3 353.8117603 431.7717613 275.8517594 0.638883281 -0.646375709 0.03077028 0.895820653 2.63256773 1.65375913 3321 immunoglobulin superfamily member 3 "GO:0003674,GO:0009986,GO:0016021,GO:0032808" molecular_function|cell surface|integral component of membrane|lacrimal gland development IGSF8 1307.724563 1213.122587 1402.32654 1.155964413 0.209096985 0.385362211 1 13.09244143 14.88114275 93185 immunoglobulin superfamily member 8 "GO:0005515,GO:0005886,GO:0007338,GO:0007399,GO:0007519,GO:0016020,GO:0016021,GO:0043231,GO:0048870,GO:0070062" protein binding|plasma membrane|single fertilization|nervous system development|skeletal muscle tissue development|membrane|integral component of membrane|intracellular membrane-bounded organelle|cell motility|extracellular exosome IGSF9 5.444873611 4.161655531 6.728091692 1.616686351 0.693039812 0.747994079 1 0.053402238 0.084889975 57549 immunoglobulin superfamily member 9 "GO:0005886,GO:0007156,GO:0007411,GO:0016021,GO:0016358,GO:0030424,GO:0030425,GO:0050807,GO:0060077,GO:0070593,GO:0098632" plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|axon guidance|integral component of membrane|dendrite development|axon|dendrite|regulation of synapse organization|inhibitory synapse|dendrite self-avoidance|cell-cell adhesion mediator activity IK 2116.755682 1963.260997 2270.250368 1.156367071 0.209599432 0.37572835 1 55.00033127 62.53630253 3550 IK cytokine "GO:0000228,GO:0000278,GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007094,GO:0016032,GO:0016607,GO:0034501,GO:0042802,GO:0071005,GO:0097431" "nuclear chromosome|mitotic cell cycle|mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|cytoplasm|mitotic spindle assembly checkpoint|viral process|nuclear speck|protein localization to kinetochore|identical protein binding|U2-type precatalytic spliceosome|mitotic spindle pole" IKBIP 1476.95095 1454.498608 1499.403291 1.030872964 0.043866558 0.856904992 1 20.22509574 20.50061618 121457 IKBKB interacting protein "GO:0005515,GO:0005783,GO:0005789,GO:0010165,GO:0016020,GO:0016021" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|response to X-ray|membrane|integral component of membrane IKBKB 1496.337615 1446.175297 1546.499933 1.06937239 0.096764333 0.686962342 1 13.14816314 13.82500285 3551 inhibitor of nuclear factor kappa B kinase subunit beta "GO:0002223,GO:0002479,GO:0002756,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0006954,GO:0007249,GO:0007252,GO:0008384,GO:0008385,GO:0009615,GO:0009898,GO:0010803,GO:0016032,GO:0018105,GO:0019901,GO:0030866,GO:0033209,GO:0035509,GO:0035631,GO:0035666,GO:0038095,GO:0042325,GO:0042802,GO:0042803,GO:0043066,GO:0043123,GO:0045087,GO:0045121,GO:0045893,GO:0045944,GO:0046982,GO:0050852,GO:0051092,GO:0051403,GO:0070498,GO:0071356,GO:0072659,GO:0097110,GO:0106310,GO:0106311,GO:1903140,GO:1903347,GO:1990459" "stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|MyD88-independent toll-like receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|protein phosphorylation|inflammatory response|I-kappaB kinase/NF-kappaB signaling|I-kappaB phosphorylation|IkappaB kinase activity|IkappaB kinase complex|response to virus|cytoplasmic side of plasma membrane|regulation of tumor necrosis factor-mediated signaling pathway|viral process|peptidyl-serine phosphorylation|protein kinase binding|cortical actin cytoskeleton organization|tumor necrosis factor-mediated signaling pathway|negative regulation of myosin-light-chain-phosphatase activity|CD40 receptor complex|TRIF-dependent toll-like receptor signaling pathway|Fc-epsilon receptor signaling pathway|regulation of phosphorylation|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|membrane raft|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|interleukin-1-mediated signaling pathway|cellular response to tumor necrosis factor|protein localization to plasma membrane|scaffold protein binding|protein serine kinase activity|protein threonine kinase activity|regulation of establishment of endothelial barrier|negative regulation of bicellular tight junction assembly|transferrin receptor binding" "hsa01523,hsa04010,hsa04014,hsa04062,hsa04064,hsa04068,hsa04150,hsa04151,hsa04210,hsa04380,hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04722,hsa04910,hsa04920,hsa04930,hsa04931,hsa04932,hsa05010,hsa05120,hsa05130,hsa05131,hsa05132,hsa05135,hsa05142,hsa05145,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05206,hsa05212,hsa05215,hsa05220,hsa05221,hsa05222,hsa05235,hsa05418" Antifolate resistance|MAPK signaling pathway|Ras signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|FoxO signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|Alzheimer disease|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Chagas disease|Toxoplasmosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|MicroRNAs in cancer|Pancreatic cancer|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis IKBKE 363.0565984 447.3779695 278.7352272 0.623041916 -0.682598869 0.021598711 0.822216713 6.6543311 4.07655072 9641 inhibitor of nuclear factor kappa B kinase subunit epsilon "GO:0004672,GO:0004674,GO:0004704,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006955,GO:0007252,GO:0008384,GO:0008630,GO:0010008,GO:0010884,GO:0016032,GO:0016605,GO:0018105,GO:0019903,GO:0031625,GO:0031966,GO:0032480,GO:0034340,GO:0035456,GO:0035666,GO:0036435,GO:0038061,GO:0042802,GO:0043123,GO:0060340,GO:0070530,GO:0098586" protein kinase activity|protein serine/threonine kinase activity|NF-kappaB-inducing kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|immune response|I-kappaB phosphorylation|IkappaB kinase activity|intrinsic apoptotic signaling pathway in response to DNA damage|endosome membrane|positive regulation of lipid storage|viral process|PML body|peptidyl-serine phosphorylation|protein phosphatase binding|ubiquitin protein ligase binding|mitochondrial membrane|negative regulation of type I interferon production|response to type I interferon|response to interferon-beta|TRIF-dependent toll-like receptor signaling pathway|K48-linked polyubiquitin modification-dependent protein binding|NIK/NF-kappaB signaling|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of type I interferon-mediated signaling pathway|K63-linked polyubiquitin modification-dependent protein binding|cellular response to virus "hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa05160,hsa05161,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05171" Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 IKBKG 312.7305032 312.1241648 313.3368417 1.003885239 0.005594354 0.997499759 1 6.509375934 6.42531762 8517 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma "GO:0000151,GO:0000187,GO:0000922,GO:0002223,GO:0002479,GO:0002756,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0006954,GO:0006955,GO:0006974,GO:0007249,GO:0007254,GO:0008385,GO:0009615,GO:0010803,GO:0016032,GO:0016239,GO:0016579,GO:0019904,GO:0031625,GO:0032991,GO:0035666,GO:0038095,GO:0042802,GO:0042803,GO:0042975,GO:0043122,GO:0043123,GO:0043276,GO:0044877,GO:0045087,GO:0045944,GO:0046872,GO:0046982,GO:0050852,GO:0051092,GO:0051403,GO:0051650,GO:0065003,GO:0070423,GO:0070498,GO:0070530,GO:0072686,GO:1901215,GO:1990450,GO:1990459" "ubiquitin ligase complex|activation of MAPK activity|spindle pole|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|MyD88-independent toll-like receptor signaling pathway|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|apoptotic process|inflammatory response|immune response|cellular response to DNA damage stimulus|I-kappaB kinase/NF-kappaB signaling|JNK cascade|IkappaB kinase complex|response to virus|regulation of tumor necrosis factor-mediated signaling pathway|viral process|positive regulation of macroautophagy|protein deubiquitination|protein domain specific binding|ubiquitin protein ligase binding|protein-containing complex|TRIF-dependent toll-like receptor signaling pathway|Fc-epsilon receptor signaling pathway|identical protein binding|protein homodimerization activity|peroxisome proliferator activated receptor binding|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|anoikis|protein-containing complex binding|innate immune response|positive regulation of transcription by RNA polymerase II|metal ion binding|protein heterodimerization activity|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|establishment of vesicle localization|protein-containing complex assembly|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|K63-linked polyubiquitin modification-dependent protein binding|mitotic spindle|negative regulation of neuron death|linear polyubiquitin binding|transferrin receptor binding" "hsa01523,hsa04010,hsa04014,hsa04062,hsa04064,hsa04151,hsa04210,hsa04380,hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04920,hsa05120,hsa05130,hsa05131,hsa05132,hsa05135,hsa05142,hsa05145,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05203,hsa05212,hsa05215,hsa05220,hsa05221,hsa05222,hsa05235,hsa05340,hsa05418" Antifolate resistance|MAPK signaling pathway|Ras signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Adipocytokine signaling pathway|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Chagas disease|Toxoplasmosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Pancreatic cancer|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Primary immunodeficiency|Fluid shear stress and atherosclerosis IKZF2 247.1001403 191.4361544 302.7641261 1.581540995 0.661330952 0.049417555 1 0.594887371 0.925095103 22807 IKAROS family zinc finger 2 "GO:0000978,GO:0003674,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0008150,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|molecular_function|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding IKZF4 136.587327 141.496288 131.678366 0.930613572 -0.103745868 0.820262415 1 1.058508107 0.968578331 64375 IKAROS family zinc finger 4 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008270,GO:0016604,GO:0019904,GO:0032991,GO:0043425,GO:0045892,GO:0045944,GO:0051260" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|zinc ion binding|nuclear body|protein domain specific binding|protein-containing complex|bHLH transcription factor binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein homooligomerization" IKZF5 283.0686467 277.7905067 288.3467868 1.038000867 0.053807649 0.877998873 1 2.838439361 2.897000136 64376 IKAROS family zinc finger 5 "GO:0000122,GO:0000977,GO:0000978,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0008270,GO:0019904,GO:0032991" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding|protein domain specific binding|protein-containing complex" IL10RB 967.382849 945.7362193 989.0294787 1.045777309 0.064575673 0.79696199 1 26.00319621 26.73850529 3588 interleukin 10 receptor subunit beta "GO:0004896,GO:0004920,GO:0005515,GO:0005886,GO:0006954,GO:0006955,GO:0007165,GO:0016021,GO:0019221,GO:0032002,GO:0038023,GO:0046427,GO:0051607" cytokine receptor activity|interleukin-10 receptor activity|protein binding|plasma membrane|inflammatory response|immune response|signal transduction|integral component of membrane|cytokine-mediated signaling pathway|interleukin-28 receptor complex|signaling receptor activity|positive regulation of receptor signaling pathway via JAK-STAT|defense response to virus "hsa04060,hsa04061,hsa04630,hsa05145,hsa05152,hsa05163" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|JAK-STAT signaling pathway|Toxoplasmosis|Tuberculosis|Human cytomegalovirus infection IL11 510.7129245 450.4992112 570.9266379 1.26731995 0.341780796 0.209260914 1 10.11030905 12.59858822 3589 interleukin 11 "GO:0005125,GO:0005142,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0008083,GO:0008284,GO:0019221,GO:0030183,GO:0030219,GO:0033138,GO:0043410,GO:0045444,GO:0045944,GO:0046888,GO:0050731,GO:1903659,GO:2000352" cytokine activity|interleukin-11 receptor binding|protein binding|extracellular region|extracellular space|cytoplasm|growth factor activity|positive regulation of cell population proliferation|cytokine-mediated signaling pathway|B cell differentiation|megakaryocyte differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of MAPK cascade|fat cell differentiation|positive regulation of transcription by RNA polymerase II|negative regulation of hormone secretion|positive regulation of peptidyl-tyrosine phosphorylation|regulation of complement-dependent cytotoxicity|negative regulation of endothelial cell apoptotic process "hsa04060,hsa04630,hsa04640,hsa05323" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway|Hematopoietic cell lineage|Rheumatoid arthritis IL11RA 142.264944 164.3853935 120.1444945 0.730870864 -0.452311573 0.275633715 1 5.094626203 3.661205891 3590 interleukin 11 receptor subunit alpha "GO:0004888,GO:0004896,GO:0004921,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0008284,GO:0009897,GO:0019221,GO:0019955,GO:0019970,GO:0032502,GO:0038154,GO:0043235,GO:0060322" transmembrane signaling receptor activity|cytokine receptor activity|interleukin-11 receptor activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|positive regulation of cell population proliferation|external side of plasma membrane|cytokine-mediated signaling pathway|cytokine binding|interleukin-11 binding|developmental process|interleukin-11-mediated signaling pathway|receptor complex|head development "hsa04060,hsa04630,hsa04640" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway|Hematopoietic cell lineage IL12A 108.0552032 86.35435226 129.7560541 1.50260005 0.587461056 0.198332546 1 3.191532595 4.715349217 3592 interleukin 12A "GO:0001916,GO:0002860,GO:0005125,GO:0005143,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0006955,GO:0007050,GO:0008083,GO:0009615,GO:0010224,GO:0016032,GO:0016477,GO:0019221,GO:0031906,GO:0032496,GO:0032700,GO:0032729,GO:0032816,GO:0032946,GO:0034393,GO:0035722,GO:0042163,GO:0042531,GO:0043514,GO:0045513,GO:0045785,GO:0045954,GO:0046982,GO:0048662,GO:0050671,GO:0050709,GO:0050830,GO:0051135,GO:0070757,GO:0097191,GO:0098586,GO:1900747,GO:1903588,GO:2000510" positive regulation of T cell mediated cytotoxicity|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|cytokine activity|interleukin-12 receptor binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|immune response|cell cycle arrest|growth factor activity|response to virus|response to UV-B|viral process|cell migration|cytokine-mediated signaling pathway|late endosome lumen|response to lipopolysaccharide|negative regulation of interleukin-17 production|positive regulation of interferon-gamma production|positive regulation of natural killer cell activation|positive regulation of mononuclear cell proliferation|positive regulation of smooth muscle cell apoptotic process|interleukin-12-mediated signaling pathway|interleukin-12 beta subunit binding|positive regulation of tyrosine phosphorylation of STAT protein|interleukin-12 complex|interleukin-27 binding|positive regulation of cell adhesion|positive regulation of natural killer cell mediated cytotoxicity|protein heterodimerization activity|negative regulation of smooth muscle cell proliferation|positive regulation of lymphocyte proliferation|negative regulation of protein secretion|defense response to Gram-positive bacterium|positive regulation of NK T cell activation|interleukin-35-mediated signaling pathway|extrinsic apoptotic signaling pathway|cellular response to virus|negative regulation of vascular endothelial growth factor signaling pathway|negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|positive regulation of dendritic cell chemotaxis "hsa04060,hsa04620,hsa04622,hsa04625,hsa04630,hsa04658,hsa04940,hsa05133,hsa05134,hsa05140,hsa05142,hsa05143,hsa05144,hsa05145,hsa05146,hsa05152,hsa05162,hsa05164,hsa05168,hsa05171,hsa05200,hsa05321,hsa05330" Cytokine-cytokine receptor interaction|Toll-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Type I diabetes mellitus|Pertussis|Legionellosis|Leishmaniasis|Chagas disease|African trypanosomiasis|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Measles|Influenza A|Herpes simplex virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Inflammatory bowel disease|Allograft rejection IL13RA1 1543.49658 1788.471464 1298.521697 0.726051113 -0.46185698 0.052699698 1 20.881084 14.90703992 3597 interleukin 13 receptor subunit alpha 1 "GO:0004896,GO:0004923,GO:0004924,GO:0005127,GO:0005515,GO:0005886,GO:0005898,GO:0007166,GO:0008284,GO:0009897,GO:0019221,GO:0019955,GO:0038165,GO:0043235,GO:0048861" cytokine receptor activity|leukemia inhibitory factor receptor activity|oncostatin-M receptor activity|ciliary neurotrophic factor receptor binding|protein binding|plasma membrane|interleukin-13 receptor complex|cell surface receptor signaling pathway|positive regulation of cell population proliferation|external side of plasma membrane|cytokine-mediated signaling pathway|cytokine binding|oncostatin-M-mediated signaling pathway|receptor complex|leukemia inhibitory factor signaling pathway "hsa04060,hsa04630,hsa05200" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway|Pathways in cancer IL13RA2 2471.68147 2512.599527 2430.763413 0.967429703 -0.047771262 0.841328692 1 100.2188481 95.33228498 3598 interleukin 13 receptor subunit alpha 2 "GO:0002638,GO:0004896,GO:0005515,GO:0005576,GO:0005615,GO:0009897,GO:0016021,GO:0016064,GO:0019221,GO:0019955,GO:0043235,GO:0043305" negative regulation of immunoglobulin production|cytokine receptor activity|protein binding|extracellular region|extracellular space|external side of plasma membrane|integral component of membrane|immunoglobulin mediated immune response|cytokine-mediated signaling pathway|cytokine binding|receptor complex|negative regulation of mast cell degranulation "hsa04060,hsa04630" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway IL15 155.4040957 156.0620824 154.7461089 0.991567628 -0.012216922 0.994016173 1 3.547166315 3.458398786 3600 interleukin 15 "GO:0001819,GO:0001866,GO:0005125,GO:0005126,GO:0005515,GO:0005576,GO:0005615,GO:0005654,GO:0005737,GO:0005768,GO:0005794,GO:0005829,GO:0006954,GO:0006955,GO:0007165,GO:0007260,GO:0007267,GO:0007568,GO:0008284,GO:0009986,GO:0014732,GO:0016607,GO:0030212,GO:0030225,GO:0032740,GO:0032819,GO:0032825,GO:0034105,GO:0035723,GO:0042102,GO:0042119,GO:0042531,GO:0045062,GO:0045580,GO:0048469,GO:0048535,GO:0048662,GO:0050691,GO:0050729,GO:0050731,GO:0050766,GO:0050778,GO:0071305,GO:0120163,GO:1904100" positive regulation of cytokine production|NK T cell proliferation|cytokine activity|cytokine receptor binding|protein binding|extracellular region|extracellular space|nucleoplasm|cytoplasm|endosome|Golgi apparatus|cytosol|inflammatory response|immune response|signal transduction|tyrosine phosphorylation of STAT protein|cell-cell signaling|aging|positive regulation of cell population proliferation|cell surface|skeletal muscle atrophy|nuclear speck|hyaluronan metabolic process|macrophage differentiation|positive regulation of interleukin-17 production|positive regulation of natural killer cell proliferation|positive regulation of natural killer cell differentiation|positive regulation of tissue remodeling|interleukin-15-mediated signaling pathway|positive regulation of T cell proliferation|neutrophil activation|positive regulation of tyrosine phosphorylation of STAT protein|extrathymic T cell selection|regulation of T cell differentiation|cell maturation|lymph node development|negative regulation of smooth muscle cell proliferation|regulation of defense response to virus by host|positive regulation of inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of phagocytosis|positive regulation of immune response|cellular response to vitamin D|negative regulation of cold-induced thermogenesis|positive regulation of protein O-linked glycosylation "hsa04060,hsa04630,hsa04668,hsa04672,hsa05166,hsa05200,hsa05323" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway|TNF signaling pathway|Intestinal immune network for IgA production|Human T-cell leukemia virus 1 infection|Pathways in cancer|Rheumatoid arthritis IL15RA 217.3980404 256.982229 177.8138519 0.691930538 -0.531300881 0.131219591 1 4.600694146 3.130091542 3601 interleukin 15 receptor subunit alpha "GO:0000139,GO:0004896,GO:0005515,GO:0005615,GO:0005768,GO:0005789,GO:0005886,GO:0009986,GO:0016021,GO:0019901,GO:0030659,GO:0031965,GO:0035723,GO:0042010,GO:0050766" Golgi membrane|cytokine receptor activity|protein binding|extracellular space|endosome|endoplasmic reticulum membrane|plasma membrane|cell surface|integral component of membrane|protein kinase binding|cytoplasmic vesicle membrane|nuclear membrane|interleukin-15-mediated signaling pathway|interleukin-15 receptor activity|positive regulation of phagocytosis "hsa04060,hsa04630,hsa04672,hsa05166,hsa05200" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway|Intestinal immune network for IgA production|Human T-cell leukemia virus 1 infection|Pathways in cancer IL16 5.405244648 3.121241648 7.689247648 2.463522058 1.300722389 0.455625732 1 0.016105088 0.039011329 3603 interleukin 16 "GO:0005125,GO:0005576,GO:0005615,GO:0005829,GO:0005886,GO:0005925,GO:0006955,GO:0016032,GO:0016607,GO:0019221,GO:0030595,GO:0032730,GO:0032735,GO:0032755,GO:0042609,GO:0050729,GO:0050930,GO:0051924,GO:0090543" cytokine activity|extracellular region|extracellular space|cytosol|plasma membrane|focal adhesion|immune response|viral process|nuclear speck|cytokine-mediated signaling pathway|leukocyte chemotaxis|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|CD4 receptor binding|positive regulation of inflammatory response|induction of positive chemotaxis|regulation of calcium ion transport|Flemming body hsa04060 Cytokine-cytokine receptor interaction IL17C 4.483717655 4.161655531 4.80577978 1.154775965 0.207612985 1 1 0.209528214 0.237909304 27189 interleukin 17C "GO:0005125,GO:0005576,GO:0005615,GO:0006954,GO:0007166,GO:0007267,GO:0097400" cytokine activity|extracellular region|extracellular space|inflammatory response|cell surface receptor signaling pathway|cell-cell signaling|interleukin-17-mediated signaling pathway "hsa04060,hsa04657" Cytokine-cytokine receptor interaction|IL-17 signaling pathway IL17RA 705.4294508 742.8555122 668.0033894 0.899237306 -0.153226206 0.551839254 1 4.62816173 4.092173335 23765 interleukin 17 receptor A "GO:0002250,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0006954,GO:0007166,GO:0030368,GO:0032747,GO:0032755,GO:0045087,GO:0072537,GO:0097400,GO:2000340" adaptive immune response|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|inflammatory response|cell surface receptor signaling pathway|interleukin-17 receptor activity|positive regulation of interleukin-23 production|positive regulation of interleukin-6 production|innate immune response|fibroblast activation|interleukin-17-mediated signaling pathway|positive regulation of chemokine (C-X-C motif) ligand 1 production "hsa04060,hsa04657" Cytokine-cytokine receptor interaction|IL-17 signaling pathway IL17RC 476.7504039 454.6608667 498.8399412 1.097169292 0.133786149 0.632981621 1 10.05987348 10.85268858 84818 interleukin 17 receptor C "GO:0005102,GO:0005515,GO:0005886,GO:0006954,GO:0009986,GO:0016021,GO:0030368,GO:0032755,GO:0050832,GO:0071621,GO:0097400,GO:1900017" signaling receptor binding|protein binding|plasma membrane|inflammatory response|cell surface|integral component of membrane|interleukin-17 receptor activity|positive regulation of interleukin-6 production|defense response to fungus|granulocyte chemotaxis|interleukin-17-mediated signaling pathway|positive regulation of cytokine production involved in inflammatory response "hsa04060,hsa04657" Cytokine-cytokine receptor interaction|IL-17 signaling pathway IL17RD 425.0612184 422.4080364 427.7144004 1.012562176 0.018010499 0.958632537 1 2.440526204 2.429832597 54756 interleukin 17 receptor D "GO:0000139,GO:0000165,GO:0005654,GO:0005794,GO:0005886,GO:0010719,GO:0016021,GO:0019221,GO:0030368,GO:0030512" Golgi membrane|MAPK cascade|nucleoplasm|Golgi apparatus|plasma membrane|negative regulation of epithelial to mesenchymal transition|integral component of membrane|cytokine-mediated signaling pathway|interleukin-17 receptor activity|negative regulation of transforming growth factor beta receptor signaling pathway IL18 2304.64658 2000.715896 2608.577265 1.303821932 0.382746848 0.105516194 1 93.25286483 119.5505679 3606 interleukin 18 "GO:0000165,GO:0001525,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005829,GO:0006954,GO:0007267,GO:0008283,GO:0010744,GO:0014068,GO:0019221,GO:0030101,GO:0030155,GO:0030431,GO:0031663,GO:0032148,GO:0032602,GO:0032609,GO:0032616,GO:0032725,GO:0032729,GO:0032740,GO:0032819,GO:0034105,GO:0035655,GO:0042088,GO:0042092,GO:0042104,GO:0042119,GO:0042267,GO:0042531,GO:0042632,GO:0045515,GO:0045630,GO:0045662,GO:0045944,GO:0048661,GO:0050729,GO:0051092,GO:0051142,GO:0051897,GO:0070328,GO:0071407,GO:0120162,GO:0150078,GO:1901224,GO:2000556" MAPK cascade|angiogenesis|cytokine activity|protein binding|extracellular region|extracellular space|cytosol|inflammatory response|cell-cell signaling|cell population proliferation|positive regulation of macrophage derived foam cell differentiation|positive regulation of phosphatidylinositol 3-kinase signaling|cytokine-mediated signaling pathway|natural killer cell activation|regulation of cell adhesion|sleep|lipopolysaccharide-mediated signaling pathway|activation of protein kinase B activity|chemokine production|interferon-gamma production|interleukin-13 production|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-17 production|positive regulation of natural killer cell proliferation|positive regulation of tissue remodeling|interleukin-18-mediated signaling pathway|T-helper 1 type immune response|type 2 immune response|positive regulation of activated T cell proliferation|neutrophil activation|natural killer cell mediated cytotoxicity|positive regulation of tyrosine phosphorylation of STAT protein|cholesterol homeostasis|interleukin-18 receptor binding|positive regulation of T-helper 2 cell differentiation|negative regulation of myoblast differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of smooth muscle cell proliferation|positive regulation of inflammatory response|positive regulation of NF-kappaB transcription factor activity|positive regulation of NK T cell proliferation|positive regulation of protein kinase B signaling|triglyceride homeostasis|cellular response to organic cyclic compound|positive regulation of cold-induced thermogenesis|positive regulation of neuroinflammatory response|positive regulation of NIK/NF-kappaB signaling|positive regulation of T-helper 1 cell cytokine production "hsa04060,hsa04061,hsa04621,hsa04623,hsa05130,hsa05131,hsa05132,hsa05134,hsa05135,hsa05143,hsa05144,hsa05152,hsa05164,hsa05321,hsa05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|NOD-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Legionellosis|Yersinia infection|African trypanosomiasis|Malaria|Tuberculosis|Influenza A|Inflammatory bowel disease|Rheumatoid arthritis IL18BP 126.2127563 146.6983575 105.7271552 0.72071124 -0.472506749 0.2750361 1 2.408929759 1.707090757 10068 interleukin 18 binding protein "GO:0005576,GO:0005615,GO:0035655,GO:0042007,GO:0042088,GO:0048019,GO:0070062,GO:0071345,GO:2000272" extracellular region|extracellular space|interleukin-18-mediated signaling pathway|interleukin-18 binding|T-helper 1 type immune response|receptor antagonist activity|extracellular exosome|cellular response to cytokine stimulus|negative regulation of signaling receptor activity IL18R1 60.03703432 87.39476614 32.6793025 0.373927455 -1.419169691 0.012241658 0.656488938 1.109179083 0.40781219 8809 interleukin 18 receptor 1 "GO:0004908,GO:0005515,GO:0005886,GO:0006954,GO:0006955,GO:0007165,GO:0030101,GO:0032729,GO:0035655,GO:0038023,GO:0042007,GO:0042008,GO:0045063,GO:0045092,GO:0050135,GO:0051092,GO:0061809,GO:0071345,GO:0120163,GO:1901224,GO:2000556" "interleukin-1 receptor activity|protein binding|plasma membrane|inflammatory response|immune response|signal transduction|natural killer cell activation|positive regulation of interferon-gamma production|interleukin-18-mediated signaling pathway|signaling receptor activity|interleukin-18 binding|interleukin-18 receptor activity|T-helper 1 cell differentiation|interleukin-18 receptor complex|NAD(P)+ nucleosidase activity|positive regulation of NF-kappaB transcription factor activity|NAD+ nucleotidase, cyclic ADP-ribose generating|cellular response to cytokine stimulus|negative regulation of cold-induced thermogenesis|positive regulation of NIK/NF-kappaB signaling|positive regulation of T-helper 1 cell cytokine production" "hsa04060,hsa04061,hsa04668,hsa05321" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|TNF signaling pathway|Inflammatory bowel disease IL1A 9516.499011 9805.900844 9227.097178 0.940973943 -0.087773322 0.725910416 1 248.8458895 230.2391891 3552 interleukin 1 alpha "GO:0001660,GO:0001819,GO:0002248,GO:0005125,GO:0005149,GO:0005507,GO:0005515,GO:0005576,GO:0005615,GO:0005829,GO:0006883,GO:0006915,GO:0006954,GO:0006955,GO:0008285,GO:0010575,GO:0010628,GO:0019221,GO:0032743,GO:0032755,GO:0032760,GO:0033092,GO:0034605,GO:0035234,GO:0045766,GO:0045840,GO:0045944,GO:0046688,GO:0050714,GO:0050999,GO:0051781,GO:0070498,GO:0071222,GO:0097192,GO:2001240" fever generation|positive regulation of cytokine production|connective tissue replacement involved in inflammatory response wound healing|cytokine activity|interleukin-1 receptor binding|copper ion binding|protein binding|extracellular region|extracellular space|cytosol|cellular sodium ion homeostasis|apoptotic process|inflammatory response|immune response|negative regulation of cell population proliferation|positive regulation of vascular endothelial growth factor production|positive regulation of gene expression|cytokine-mediated signaling pathway|positive regulation of interleukin-2 production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of immature T cell proliferation in thymus|cellular response to heat|ectopic germ cell programmed cell death|positive regulation of angiogenesis|positive regulation of mitotic nuclear division|positive regulation of transcription by RNA polymerase II|response to copper ion|positive regulation of protein secretion|regulation of nitric-oxide synthase activity|positive regulation of cell division|interleukin-1-mediated signaling pathway|cellular response to lipopolysaccharide|extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa04010,hsa04060,hsa04217,hsa04218,hsa04380,hsa04640,hsa04932,hsa04933,hsa04940,hsa05010,hsa05020,hsa05022,hsa05133,hsa05140,hsa05152,hsa05162,hsa05164,hsa05321,hsa05323,hsa05332,hsa05418" MAPK signaling pathway|Cytokine-cytokine receptor interaction|Necroptosis|Cellular senescence|Osteoclast differentiation|Hematopoietic cell lineage|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Type I diabetes mellitus|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pertussis|Leishmaniasis|Tuberculosis|Measles|Influenza A|Inflammatory bowel disease|Rheumatoid arthritis|Graft-versus-host disease|Fluid shear stress and atherosclerosis IL1B 39522.9407 31787.76536 47258.11604 1.486676258 0.572090517 0.065628029 1 1079.856533 1578.532924 3553 interleukin 1 beta "GO:0000165,GO:0000187,GO:0001660,GO:0001934,GO:0002711,GO:0005125,GO:0005149,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0005764,GO:0005829,GO:0006915,GO:0006954,GO:0006955,GO:0007165,GO:0007267,GO:0007566,GO:0008284,GO:0008285,GO:0010573,GO:0010575,GO:0010628,GO:0010718,GO:0010829,GO:0014805,GO:0019221,GO:0019904,GO:0030213,GO:0030335,GO:0030730,GO:0030949,GO:0031394,GO:0031622,GO:0031663,GO:0032308,GO:0032496,GO:0032725,GO:0032729,GO:0032743,GO:0032755,GO:0032757,GO:0033092,GO:0033129,GO:0034116,GO:0035066,GO:0035505,GO:0035690,GO:0042102,GO:0043122,GO:0043407,GO:0043491,GO:0045429,GO:0045766,GO:0045833,GO:0045840,GO:0045893,GO:0045917,GO:0046330,GO:0046627,GO:0046827,GO:0050729,GO:0050766,GO:0050767,GO:0050768,GO:0050796,GO:0050805,GO:0050995,GO:0050996,GO:0050999,GO:0051044,GO:0051091,GO:0051092,GO:0051781,GO:0060252,GO:0060355,GO:0060559,GO:0070164,GO:0070372,GO:0070487,GO:0070498,GO:0070555,GO:0071222,GO:0071260,GO:0071310,GO:0071407,GO:0071639,GO:0150078,GO:1900745,GO:1901224,GO:1902680,GO:1903140,GO:1903597,GO:2000556,GO:2001240" "MAPK cascade|activation of MAPK activity|fever generation|positive regulation of protein phosphorylation|positive regulation of T cell mediated immunity|cytokine activity|interleukin-1 receptor binding|integrin binding|protein binding|extracellular region|extracellular space|lysosome|cytosol|apoptotic process|inflammatory response|immune response|signal transduction|cell-cell signaling|embryo implantation|positive regulation of cell population proliferation|negative regulation of cell population proliferation|vascular endothelial growth factor production|positive regulation of vascular endothelial growth factor production|positive regulation of gene expression|positive regulation of epithelial to mesenchymal transition|negative regulation of glucose transmembrane transport|smooth muscle adaptation|cytokine-mediated signaling pathway|protein domain specific binding|hyaluronan biosynthetic process|positive regulation of cell migration|sequestering of triglyceride|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of prostaglandin biosynthetic process|positive regulation of fever generation|lipopolysaccharide-mediated signaling pathway|positive regulation of prostaglandin secretion|response to lipopolysaccharide|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of immature T cell proliferation in thymus|positive regulation of histone phosphorylation|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of myosin light chain kinase activity|cellular response to drug|positive regulation of T cell proliferation|regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of MAP kinase activity|protein kinase B signaling|positive regulation of nitric oxide biosynthetic process|positive regulation of angiogenesis|negative regulation of lipid metabolic process|positive regulation of mitotic nuclear division|positive regulation of transcription, DNA-templated|positive regulation of complement activation|positive regulation of JNK cascade|negative regulation of insulin receptor signaling pathway|positive regulation of protein export from nucleus|positive regulation of inflammatory response|positive regulation of phagocytosis|regulation of neurogenesis|negative regulation of neurogenesis|regulation of insulin secretion|negative regulation of synaptic transmission|negative regulation of lipid catabolic process|positive regulation of lipid catabolic process|regulation of nitric-oxide synthase activity|positive regulation of membrane protein ectodomain proteolysis|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of cell division|positive regulation of glial cell proliferation|positive regulation of cell adhesion molecule production|positive regulation of calcidiol 1-monooxygenase activity|negative regulation of adiponectin secretion|regulation of ERK1 and ERK2 cascade|monocyte aggregation|interleukin-1-mediated signaling pathway|response to interleukin-1|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|cellular response to organic substance|cellular response to organic cyclic compound|positive regulation of monocyte chemotactic protein-1 production|positive regulation of neuroinflammatory response|positive regulation of p38MAPK cascade|positive regulation of NIK/NF-kappaB signaling|positive regulation of RNA biosynthetic process|regulation of establishment of endothelial barrier|negative regulation of gap junction assembly|positive regulation of T-helper 1 cell cytokine production|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa01523,hsa04010,hsa04060,hsa04064,hsa04217,hsa04380,hsa04620,hsa04621,hsa04623,hsa04625,hsa04640,hsa04657,hsa04659,hsa04668,hsa04750,hsa04932,hsa04933,hsa04940,hsa05010,hsa05020,hsa05022,hsa05130,hsa05131,hsa05132,hsa05133,hsa05134,hsa05135,hsa05140,hsa05142,hsa05143,hsa05144,hsa05146,hsa05152,hsa05162,hsa05163,hsa05164,hsa05168,hsa05171,hsa05321,hsa05323,hsa05332,hsa05418" Antifolate resistance|MAPK signaling pathway|Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Necroptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|Hematopoietic cell lineage|IL-17 signaling pathway|Th17 cell differentiation|TNF signaling pathway|Inflammatory mediator regulation of TRP channels|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Type I diabetes mellitus|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Leishmaniasis|Chagas disease|African trypanosomiasis|Malaria|Amoebiasis|Tuberculosis|Measles|Human cytomegalovirus infection|Influenza A|Herpes simplex virus 1 infection|Coronavirus disease - COVID-19|Inflammatory bowel disease|Rheumatoid arthritis|Graft-versus-host disease|Fluid shear stress and atherosclerosis IL1R1 140.3080335 150.860013 129.7560541 0.860108994 -0.217408603 0.610462698 1 1.198797145 1.013842208 3554 interleukin 1 receptor type 1 "GO:0002020,GO:0004888,GO:0004908,GO:0004909,GO:0005161,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0007166,GO:0009897,GO:0016020,GO:0019221,GO:0019966,GO:0032729,GO:0050135,GO:0050727,GO:0061809,GO:0070498,GO:0070555,GO:2000391,GO:2000556,GO:2000661" "protease binding|transmembrane signaling receptor activity|interleukin-1 receptor activity|interleukin-1, type I, activating receptor activity|platelet-derived growth factor receptor binding|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|cell surface receptor signaling pathway|external side of plasma membrane|membrane|cytokine-mediated signaling pathway|interleukin-1 binding|positive regulation of interferon-gamma production|NAD(P)+ nucleosidase activity|regulation of inflammatory response|NAD+ nucleotidase, cyclic ADP-ribose generating|interleukin-1-mediated signaling pathway|response to interleukin-1|positive regulation of neutrophil extravasation|positive regulation of T-helper 1 cell cytokine production|positive regulation of interleukin-1-mediated signaling pathway" "hsa04010,hsa04060,hsa04064,hsa04380,hsa04640,hsa04659,hsa04750,hsa05130,hsa05131,hsa05146,hsa05163,hsa05166,hsa05418" MAPK signaling pathway|Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Osteoclast differentiation|Hematopoietic cell lineage|Th17 cell differentiation|Inflammatory mediator regulation of TRP channels|Pathogenic Escherichia coli infection|Shigellosis|Amoebiasis|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Fluid shear stress and atherosclerosis IL1RAP 634.5775112 560.7830827 708.3719396 1.263183504 0.337064236 0.195596686 1 2.772647994 3.443755904 3556 interleukin 1 receptor accessory protein "GO:0002114,GO:0004908,GO:0005149,GO:0005576,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0016020,GO:0019221,GO:0032736,GO:0032754,GO:0032755,GO:0038172,GO:0045087,GO:0050135,GO:0051092,GO:0051965,GO:0061809,GO:0065003,GO:0070498,GO:0098978,GO:0099151,GO:0099545,GO:0099560,GO:1905606" "interleukin-33 receptor activity|interleukin-1 receptor activity|interleukin-1 receptor binding|extracellular region|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|membrane|cytokine-mediated signaling pathway|positive regulation of interleukin-13 production|positive regulation of interleukin-5 production|positive regulation of interleukin-6 production|interleukin-33-mediated signaling pathway|innate immune response|NAD(P)+ nucleosidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of synapse assembly|NAD+ nucleotidase, cyclic ADP-ribose generating|protein-containing complex assembly|interleukin-1-mediated signaling pathway|glutamatergic synapse|regulation of postsynaptic density assembly|trans-synaptic signaling by trans-synaptic complex|synaptic membrane adhesion|regulation of presynapse assembly" "hsa04010,hsa04060,hsa04659,hsa04750" MAPK signaling pathway|Cytokine-cytokine receptor interaction|Th17 cell differentiation|Inflammatory mediator regulation of TRP channels IL1RAPL1 390.4400967 371.4277561 409.4524373 1.102374366 0.140614246 0.634491927 1 2.248969445 2.437720107 11141 interleukin 1 receptor accessory protein like 1 "GO:0005102,GO:0005515,GO:0005737,GO:0005886,GO:0007157,GO:0007165,GO:0009986,GO:0010975,GO:0016021,GO:0019966,GO:0030182,GO:0030424,GO:0030425,GO:0045211,GO:0045920,GO:0050135,GO:0050775,GO:0051965,GO:0061809,GO:0071345,GO:0097105,GO:0098978,GO:0099175,GO:0099545,GO:1905606" "signaling receptor binding|protein binding|cytoplasm|plasma membrane|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|signal transduction|cell surface|regulation of neuron projection development|integral component of membrane|interleukin-1 binding|neuron differentiation|axon|dendrite|postsynaptic membrane|negative regulation of exocytosis|NAD(P)+ nucleosidase activity|positive regulation of dendrite morphogenesis|positive regulation of synapse assembly|NAD+ nucleotidase, cyclic ADP-ribose generating|cellular response to cytokine stimulus|presynaptic membrane assembly|glutamatergic synapse|regulation of postsynapse organization|trans-synaptic signaling by trans-synaptic complex|regulation of presynapse assembly" IL1RL1 66.15560031 109.2434577 23.06774294 0.211159034 -2.243598127 8.34E-05 0.032569251 1.135590681 0.235777666 9173 interleukin 1 receptor like 1 "GO:0002113,GO:0002114,GO:0002826,GO:0004896,GO:0004908,GO:0005515,GO:0005576,GO:0005829,GO:0005886,GO:0005925,GO:0006955,GO:0007165,GO:0009897,GO:0016021,GO:0032689,GO:0032722,GO:0032754,GO:0038172,GO:0043032,GO:0050135,GO:0050729,GO:0061809" "interleukin-33 binding|interleukin-33 receptor activity|negative regulation of T-helper 1 type immune response|cytokine receptor activity|interleukin-1 receptor activity|protein binding|extracellular region|cytosol|plasma membrane|focal adhesion|immune response|signal transduction|external side of plasma membrane|integral component of membrane|negative regulation of interferon-gamma production|positive regulation of chemokine production|positive regulation of interleukin-5 production|interleukin-33-mediated signaling pathway|positive regulation of macrophage activation|NAD(P)+ nucleosidase activity|positive regulation of inflammatory response|NAD+ nucleotidase, cyclic ADP-ribose generating" hsa04060 Cytokine-cytokine receptor interaction IL1RL2 13.57003986 15.60620824 11.53387147 0.739056617 -0.436243205 0.713968318 1 0.165121858 0.119992321 8808 interleukin 1 receptor like 2 "GO:0004908,GO:0004909,GO:0005886,GO:0005887,GO:0006954,GO:0006968,GO:0007165,GO:0019221,GO:0032755,GO:0045087,GO:0045582,GO:0050135,GO:0050727,GO:0061809,GO:0070498,GO:0071345" "interleukin-1 receptor activity|interleukin-1, type I, activating receptor activity|plasma membrane|integral component of plasma membrane|inflammatory response|cellular defense response|signal transduction|cytokine-mediated signaling pathway|positive regulation of interleukin-6 production|innate immune response|positive regulation of T cell differentiation|NAD(P)+ nucleosidase activity|regulation of inflammatory response|NAD+ nucleotidase, cyclic ADP-ribose generating|interleukin-1-mediated signaling pathway|cellular response to cytokine stimulus" hsa04060 Cytokine-cytokine receptor interaction IL20 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.112247258 0.10196113 50604 interleukin 20 "GO:0005125,GO:0005576,GO:0005615,GO:0019221,GO:0042531,GO:0045517,GO:0045518,GO:0045606,GO:0045618,GO:0045672,GO:0050727" cytokine activity|extracellular region|extracellular space|cytokine-mediated signaling pathway|positive regulation of tyrosine phosphorylation of STAT protein|interleukin-20 receptor binding|interleukin-22 receptor binding|positive regulation of epidermal cell differentiation|positive regulation of keratinocyte differentiation|positive regulation of osteoclast differentiation|regulation of inflammatory response "hsa04060,hsa04061,hsa04630" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|JAK-STAT signaling pathway IL20RB 8.645373186 12.48496659 4.80577978 0.384925322 -1.377349516 0.279195182 1 0.201664564 0.076326835 53833 interleukin 20 receptor subunit beta "GO:0001808,GO:0002437,GO:0002765,GO:0004896,GO:0005515,GO:0005886,GO:0016021,GO:0019221,GO:0032689,GO:0032703,GO:0032733,GO:0032753,GO:0042015,GO:0042130,GO:0048873" negative regulation of type IV hypersensitivity|inflammatory response to antigenic stimulus|immune response-inhibiting signal transduction|cytokine receptor activity|protein binding|plasma membrane|integral component of membrane|cytokine-mediated signaling pathway|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|positive regulation of interleukin-10 production|positive regulation of interleukin-4 production|interleukin-20 binding|negative regulation of T cell proliferation|homeostasis of number of cells within a tissue "hsa04060,hsa04061,hsa04630" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|JAK-STAT signaling pathway IL22RA1 32.43146789 18.72744989 46.13548589 2.463522058 1.300722389 0.067772255 1 0.347997765 0.842954413 58985 interleukin 22 receptor subunit alpha 1 "GO:0004896,GO:0004904,GO:0005515,GO:0005886,GO:0008150,GO:0016021,GO:0019221,GO:0042015,GO:0050829" cytokine receptor activity|interferon receptor activity|protein binding|plasma membrane|biological_process|integral component of membrane|cytokine-mediated signaling pathway|interleukin-20 binding|defense response to Gram-negative bacterium "hsa04060,hsa04061,hsa04630" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|JAK-STAT signaling pathway IL23A 8.486857333 8.323311061 8.650403604 1.039298368 0.055609892 1 1 0.361431907 0.369349838 51561 interleukin 23 subunit alpha "GO:0001916,GO:0002230,GO:0002827,GO:0005125,GO:0005515,GO:0005576,GO:0005788,GO:0006954,GO:0010536,GO:0019221,GO:0032693,GO:0032725,GO:0032729,GO:0032733,GO:0032735,GO:0032740,GO:0032760,GO:0032816,GO:0032819,GO:0034105,GO:0038155,GO:0042098,GO:0042102,GO:0042104,GO:0042509,GO:0042531,GO:0043382,GO:0045087,GO:0045519,GO:0045672,GO:0045944,GO:0048771,GO:0050729,GO:0050829,GO:0051135,GO:0051142,GO:0051607,GO:0070743,GO:0090023,GO:1901224,GO:2000318,GO:2000330" positive regulation of T cell mediated cytotoxicity|positive regulation of defense response to virus by host|positive regulation of T-helper 1 type immune response|cytokine activity|protein binding|extracellular region|endoplasmic reticulum lumen|inflammatory response|positive regulation of activation of Janus kinase activity|cytokine-mediated signaling pathway|negative regulation of interleukin-10 production|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of tumor necrosis factor production|positive regulation of natural killer cell activation|positive regulation of natural killer cell proliferation|positive regulation of tissue remodeling|interleukin-23-mediated signaling pathway|T cell proliferation|positive regulation of T cell proliferation|positive regulation of activated T cell proliferation|regulation of tyrosine phosphorylation of STAT protein|positive regulation of tyrosine phosphorylation of STAT protein|positive regulation of memory T cell differentiation|innate immune response|interleukin-23 receptor binding|positive regulation of osteoclast differentiation|positive regulation of transcription by RNA polymerase II|tissue remodeling|positive regulation of inflammatory response|defense response to Gram-negative bacterium|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|defense response to virus|interleukin-23 complex|positive regulation of neutrophil chemotaxis|positive regulation of NIK/NF-kappaB signaling|positive regulation of T-helper 17 type immune response|positive regulation of T-helper 17 cell lineage commitment "hsa04060,hsa04625,hsa04630,hsa04659,hsa05133,hsa05152,hsa05200,hsa05321,hsa05323" Cytokine-cytokine receptor interaction|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Th17 cell differentiation|Pertussis|Tuberculosis|Pathways in cancer|Inflammatory bowel disease|Rheumatoid arthritis IL24 338.6314099 436.9738307 240.288989 0.549893317 -0.862776343 0.004528929 0.412329403 11.55623896 6.248361294 11009 interleukin 24 "GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0006915,GO:0008284,GO:0008285,GO:0019221,GO:0030336,GO:0042060,GO:0042501,GO:0042531,GO:0071222,GO:0071353" cytokine activity|protein binding|extracellular region|extracellular space|apoptotic process|positive regulation of cell population proliferation|negative regulation of cell population proliferation|cytokine-mediated signaling pathway|negative regulation of cell migration|wound healing|serine phosphorylation of STAT protein|positive regulation of tyrosine phosphorylation of STAT protein|cellular response to lipopolysaccharide|cellular response to interleukin-4 "hsa04060,hsa04061,hsa04630" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|JAK-STAT signaling pathway IL27RA 149.4786441 151.9004269 147.0568613 0.968113548 -0.046751826 0.925607967 1 2.748015797 2.615873278 9466 interleukin 27 receptor subunit alpha "GO:0002827,GO:0002829,GO:0004888,GO:0004896,GO:0005143,GO:0005515,GO:0005886,GO:0005887,GO:0006955,GO:0007166,GO:0009897,GO:0019221,GO:0019955,GO:0032700,GO:0032715,GO:0032720,GO:0032729,GO:0042019,GO:0042022,GO:0042104,GO:0043235,GO:0045509,GO:0048302,GO:0050830,GO:0070106,GO:0070757,GO:0072536,GO:2000317,GO:2000408" positive regulation of T-helper 1 type immune response|negative regulation of type 2 immune response|transmembrane signaling receptor activity|cytokine receptor activity|interleukin-12 receptor binding|protein binding|plasma membrane|integral component of plasma membrane|immune response|cell surface receptor signaling pathway|external side of plasma membrane|cytokine-mediated signaling pathway|cytokine binding|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|positive regulation of interferon-gamma production|interleukin-23 binding|interleukin-12 receptor complex|positive regulation of activated T cell proliferation|receptor complex|interleukin-27 receptor activity|regulation of isotype switching to IgG isotypes|defense response to Gram-positive bacterium|interleukin-27-mediated signaling pathway|interleukin-35-mediated signaling pathway|interleukin-23 receptor complex|negative regulation of T-helper 17 type immune response|negative regulation of T cell extravasation "hsa04060,hsa04630,hsa04659" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway|Th17 cell differentiation IL31RA 2097.609364 2369.022411 1826.196316 0.770864939 -0.375449983 0.112415434 1 14.06188099 10.65842148 133396 interleukin 31 receptor A "GO:0000165,GO:0002067,GO:0002438,GO:0003713,GO:0004896,GO:0005886,GO:0006952,GO:0007169,GO:0007259,GO:0008284,GO:0009897,GO:0016021,GO:0019221,GO:0019901,GO:0019955,GO:0030224,GO:0030225,GO:0030424,GO:0042531,GO:0042592,GO:0042734,GO:0043031,GO:0043066,GO:0043235,GO:0045893,GO:0051916,GO:0098542" "MAPK cascade|glandular epithelial cell differentiation|acute inflammatory response to antigenic stimulus|transcription coactivator activity|cytokine receptor activity|plasma membrane|defense response|transmembrane receptor protein tyrosine kinase signaling pathway|receptor signaling pathway via JAK-STAT|positive regulation of cell population proliferation|external side of plasma membrane|integral component of membrane|cytokine-mediated signaling pathway|protein kinase binding|cytokine binding|monocyte differentiation|macrophage differentiation|axon|positive regulation of tyrosine phosphorylation of STAT protein|homeostatic process|presynaptic membrane|negative regulation of macrophage activation|negative regulation of apoptotic process|receptor complex|positive regulation of transcription, DNA-templated|granulocyte colony-stimulating factor binding|defense response to other organism" hsa04060 Cytokine-cytokine receptor interaction IL32 60.64152961 78.0310412 43.25201802 0.554292463 -0.851280704 0.127783535 1 4.468211646 2.435251884 9235 interleukin 32 "GO:0005125,GO:0005515,GO:0005615,GO:0005829,GO:0006952,GO:0006955,GO:0007155,GO:0016020,GO:0019221" cytokine activity|protein binding|extracellular space|cytosol|defense response|immune response|cell adhesion|membrane|cytokine-mediated signaling pathway hsa04060 Cytokine-cytokine receptor interaction IL33 135.0021685 99.87973273 170.1246042 1.703294548 0.768327939 0.068687642 1 1.507039232 2.523977582 90865 interleukin 33 "GO:0000122,GO:0001819,GO:0002112,GO:0002282,GO:0002638,GO:0002639,GO:0002686,GO:0002826,GO:0002830,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0010186,GO:0010628,GO:0016579,GO:0030133,GO:0032436,GO:0032689,GO:0032722,GO:0032736,GO:0032753,GO:0032754,GO:0032755,GO:0032760,GO:0038172,GO:0043032,GO:0043231,GO:0045345,GO:0045348,GO:0045944,GO:0050729,GO:0051607,GO:0051770,GO:0061518,GO:0097191,GO:0120042,GO:0150078,GO:0150142,GO:0150145" negative regulation of transcription by RNA polymerase II|positive regulation of cytokine production|interleukin-33 receptor binding|microglial cell activation involved in immune response|negative regulation of immunoglobulin production|positive regulation of immunoglobulin production|negative regulation of leukocyte migration|negative regulation of T-helper 1 type immune response|positive regulation of type 2 immune response|cytokine activity|protein binding|extracellular region|extracellular space|nucleus|nucleoplasm|chromosome|cytoplasm|positive regulation of cellular defense response|positive regulation of gene expression|protein deubiquitination|transport vesicle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of interferon-gamma production|positive regulation of chemokine production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|interleukin-33-mediated signaling pathway|positive regulation of macrophage activation|intracellular membrane-bounded organelle|positive regulation of MHC class I biosynthetic process|positive regulation of MHC class II biosynthetic process|positive regulation of transcription by RNA polymerase II|positive regulation of inflammatory response|defense response to virus|positive regulation of nitric-oxide synthase biosynthetic process|microglial cell proliferation|extrinsic apoptotic signaling pathway|negative regulation of macrophage proliferation|positive regulation of neuroinflammatory response|positive regulation of CD86 production|positive regulation of CD80 production "hsa04060,hsa04217,hsa04623,hsa05164" Cytokine-cytokine receptor interaction|Necroptosis|Cytosolic DNA-sensing pathway|Influenza A IL36G 5.603389465 8.323311061 2.883467868 0.346432789 -1.529352609 0.352439314 1 0.36680414 0.124946587 56300 interleukin 36 gamma "GO:0002437,GO:0005125,GO:0005149,GO:0005576,GO:0005615,GO:0005737,GO:0006954,GO:0007267,GO:0010628,GO:0019221,GO:0045087,GO:0071222" inflammatory response to antigenic stimulus|cytokine activity|interleukin-1 receptor binding|extracellular region|extracellular space|cytoplasm|inflammatory response|cell-cell signaling|positive regulation of gene expression|cytokine-mediated signaling pathway|innate immune response|cellular response to lipopolysaccharide hsa04060 Cytokine-cytokine receptor interaction IL36RN 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.061421434 0.01859763 26525 interleukin 36 receptor antagonist "GO:0001960,GO:0002437,GO:0005125,GO:0005149,GO:0005152,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0006954,GO:0019221,GO:0019732,GO:0032689,GO:0032700,GO:0032715,GO:0045087,GO:0071222" negative regulation of cytokine-mediated signaling pathway|inflammatory response to antigenic stimulus|cytokine activity|interleukin-1 receptor binding|interleukin-1 receptor antagonist activity|protein binding|extracellular region|extracellular space|cytoplasm|inflammatory response|cytokine-mediated signaling pathway|antifungal humoral response|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|innate immune response|cellular response to lipopolysaccharide hsa04060 Cytokine-cytokine receptor interaction IL37 5.925451589 4.161655531 7.689247648 1.847641543 0.88568489 0.619277139 1 0.238560587 0.433398688 27178 interleukin 37 "GO:0002437,GO:0005125,GO:0005149,GO:0005515,GO:0005576,GO:0005615,GO:0005654,GO:0005829,GO:0006954,GO:0006955,GO:0010628,GO:0019221,GO:0032715,GO:0032720,GO:0043231,GO:0050727,GO:0071222,GO:0071345" inflammatory response to antigenic stimulus|cytokine activity|interleukin-1 receptor binding|protein binding|extracellular region|extracellular space|nucleoplasm|cytosol|inflammatory response|immune response|positive regulation of gene expression|cytokine-mediated signaling pathway|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|intracellular membrane-bounded organelle|regulation of inflammatory response|cellular response to lipopolysaccharide|cellular response to cytokine stimulus "hsa04060,hsa04061" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor IL4I1 64.60504032 81.15228285 48.0577978 0.592192802 -0.755861139 0.166823137 1 1.760548042 1.02513765 259307 interleukin 4 induced 1 "GO:0001669,GO:0001716,GO:0002250,GO:0005515,GO:0005576,GO:0005764,GO:0006559,GO:0009063,GO:0016491,GO:0046592,GO:0055114" acrosomal vesicle|L-amino-acid oxidase activity|adaptive immune response|protein binding|extracellular region|lysosome|L-phenylalanine catabolic process|cellular amino acid catabolic process|oxidoreductase activity|polyamine oxidase activity|oxidation-reduction process "hsa00250,hsa00270,hsa00280,hsa00350,hsa00360,hsa00380,hsa00400" "Alanine, aspartate and glutamate metabolism|Cysteine and methionine metabolism|Valine, leucine and isoleucine degradation|Tyrosine metabolism|Phenylalanine metabolism|Tryptophan metabolism|Phenylalanine, tyrosine and tryptophan biosynthesis" IL4R 1042.802795 1121.566165 964.0394239 0.859547527 -0.218350682 0.373288381 1 10.6052312 8.963161353 3566 interleukin 4 receptor "GO:0002532,GO:0002639,GO:0004913,GO:0005515,GO:0005615,GO:0005654,GO:0005886,GO:0005887,GO:0006955,GO:0007165,GO:0016064,GO:0019221,GO:0030728,GO:0032722,GO:0034451,GO:0035771,GO:0042127,GO:0042832,GO:0043032,GO:0043235,GO:0043306,GO:0043627,GO:0045626,GO:0045630,GO:0120162,GO:1901741,GO:1990834" production of molecular mediator involved in inflammatory response|positive regulation of immunoglobulin production|interleukin-4 receptor activity|protein binding|extracellular space|nucleoplasm|plasma membrane|integral component of plasma membrane|immune response|signal transduction|immunoglobulin mediated immune response|cytokine-mediated signaling pathway|ovulation|positive regulation of chemokine production|centriolar satellite|interleukin-4-mediated signaling pathway|regulation of cell population proliferation|defense response to protozoan|positive regulation of macrophage activation|receptor complex|positive regulation of mast cell degranulation|response to estrogen|negative regulation of T-helper 1 cell differentiation|positive regulation of T-helper 2 cell differentiation|positive regulation of cold-induced thermogenesis|positive regulation of myoblast fusion|response to odorant "hsa04060,hsa04151,hsa04630,hsa04640,hsa04658,hsa04659,hsa05200,hsa05321" Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|JAK-STAT signaling pathway|Hematopoietic cell lineage|Th1 and Th2 cell differentiation|Th17 cell differentiation|Pathways in cancer|Inflammatory bowel disease IL6 4257.941085 4820.237518 3695.644651 0.766693474 -0.383278194 0.108369862 1 151.6787837 114.345159 3569 interleukin 6 "GO:0001781,GO:0002314,GO:0002377,GO:0002384,GO:0002446,GO:0002548,GO:0002639,GO:0002675,GO:0002690,GO:0005125,GO:0005138,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005896,GO:0006953,GO:0006954,GO:0006959,GO:0008083,GO:0008284,GO:0008285,GO:0010573,GO:0010574,GO:0010575,GO:0010628,GO:0010718,GO:0010888,GO:0014823,GO:0019221,GO:0030168,GO:0031018,GO:0031175,GO:0032494,GO:0032625,GO:0032682,GO:0032722,GO:0032731,GO:0032733,GO:0032740,GO:0032755,GO:0032757,GO:0032760,GO:0032966,GO:0033138,GO:0035633,GO:0042102,GO:0042531,GO:0042593,GO:0043065,GO:0043066,GO:0043410,GO:0043687,GO:0044267,GO:0045599,GO:0045669,GO:0045727,GO:0045765,GO:0045779,GO:0045893,GO:0045944,GO:0046427,GO:0048661,GO:0050731,GO:0050768,GO:0050796,GO:0050829,GO:0050830,GO:0050871,GO:0051091,GO:0051092,GO:0051384,GO:0051607,GO:0060252,GO:0061470,GO:0061888,GO:0070050,GO:0070091,GO:0070092,GO:0070102,GO:0070301,GO:0071222,GO:0072540,GO:0072574,GO:0090091,GO:0097421,GO:0098586,GO:0150077,GO:0150078,GO:1900017,GO:1902512,GO:1903800,GO:1903978,GO:1904894,GO:1904996,GO:2000553,GO:2000635,GO:2000660,GO:2000676" "neutrophil apoptotic process|germinal center B cell differentiation|immunoglobulin production|hepatic immune response|neutrophil mediated immunity|monocyte chemotaxis|positive regulation of immunoglobulin production|positive regulation of acute inflammatory response|positive regulation of leukocyte chemotaxis|cytokine activity|interleukin-6 receptor binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|interleukin-6 receptor complex|acute-phase response|inflammatory response|humoral immune response|growth factor activity|positive regulation of cell population proliferation|negative regulation of cell population proliferation|vascular endothelial growth factor production|regulation of vascular endothelial growth factor production|positive regulation of vascular endothelial growth factor production|positive regulation of gene expression|positive regulation of epithelial to mesenchymal transition|negative regulation of lipid storage|response to activity|cytokine-mediated signaling pathway|platelet activation|endocrine pancreas development|neuron projection development|response to peptidoglycan|interleukin-21 production|negative regulation of chemokine production|positive regulation of chemokine production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|negative regulation of collagen biosynthetic process|positive regulation of peptidyl-serine phosphorylation|maintenance of blood-brain barrier|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|glucose homeostasis|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of MAPK cascade|post-translational protein modification|cellular protein metabolic process|negative regulation of fat cell differentiation|positive regulation of osteoblast differentiation|positive regulation of translation|regulation of angiogenesis|negative regulation of bone resorption|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of receptor signaling pathway via JAK-STAT|positive regulation of smooth muscle cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of neurogenesis|regulation of insulin secretion|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|positive regulation of B cell activation|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|response to glucocorticoid|defense response to virus|positive regulation of glial cell proliferation|T follicular helper cell differentiation|regulation of astrocyte activation|neuron cellular homeostasis|glucagon secretion|regulation of glucagon secretion|interleukin-6-mediated signaling pathway|cellular response to hydrogen peroxide|cellular response to lipopolysaccharide|T-helper 17 cell lineage commitment|hepatocyte proliferation|positive regulation of extracellular matrix disassembly|liver regeneration|cellular response to virus|regulation of neuroinflammatory response|positive regulation of neuroinflammatory response|positive regulation of cytokine production involved in inflammatory response|positive regulation of apoptotic DNA fragmentation|positive regulation of production of miRNAs involved in gene silencing by miRNA|regulation of microglial cell activation|positive regulation of receptor signaling pathway via STAT|positive regulation of leukocyte adhesion to vascular endothelial cell|positive regulation of T-helper 2 cell cytokine production|negative regulation of primary miRNA processing|negative regulation of interleukin-1-mediated signaling pathway|positive regulation of type B pancreatic cell apoptotic process" "hsa01521,hsa01523,hsa04060,hsa04061,hsa04066,hsa04068,hsa04151,hsa04218,hsa04620,hsa04621,hsa04623,hsa04625,hsa04630,hsa04640,hsa04657,hsa04659,hsa04668,hsa04672,hsa04931,hsa04932,hsa04933,hsa05010,hsa05020,hsa05022,hsa05130,hsa05132,hsa05133,hsa05134,hsa05135,hsa05142,hsa05143,hsa05144,hsa05146,hsa05152,hsa05161,hsa05162,hsa05163,hsa05164,hsa05166,hsa05167,hsa05168,hsa05169,hsa05171,hsa05200,hsa05202,hsa05321,hsa05323,hsa05332,hsa05410" EGFR tyrosine kinase inhibitor resistance|Antifolate resistance|Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|HIF-1 signaling pathway|FoxO signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Hematopoietic cell lineage|IL-17 signaling pathway|Th17 cell differentiation|TNF signaling pathway|Intestinal immune network for IgA production|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Chagas disease|African trypanosomiasis|Malaria|Amoebiasis|Tuberculosis|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Pathways in cancer|Transcriptional misregulation in cancer|Inflammatory bowel disease|Rheumatoid arthritis|Graft-versus-host disease|Hypertrophic cardiomyopathy IL6R 74.53363159 89.47559391 59.59166927 0.666010324 -0.586383554 0.260523885 1 1.569223792 1.02763059 3570 interleukin 6 receptor "GO:0002384,GO:0002548,GO:0002690,GO:0004896,GO:0004897,GO:0004915,GO:0004921,GO:0005138,GO:0005515,GO:0005576,GO:0005886,GO:0005896,GO:0006953,GO:0008284,GO:0009897,GO:0010536,GO:0010573,GO:0016324,GO:0019221,GO:0019899,GO:0019955,GO:0019970,GO:0019981,GO:0031018,GO:0032722,GO:0032755,GO:0034097,GO:0038154,GO:0042531,GO:0042803,GO:0043235,GO:0045669,GO:0048661,GO:0050731,GO:0050829,GO:0070102,GO:0070110,GO:0070119,GO:0070120,GO:0072126,GO:0072540,GO:0097191" hepatic immune response|monocyte chemotaxis|positive regulation of leukocyte chemotaxis|cytokine receptor activity|ciliary neurotrophic factor receptor activity|interleukin-6 receptor activity|interleukin-11 receptor activity|interleukin-6 receptor binding|protein binding|extracellular region|plasma membrane|interleukin-6 receptor complex|acute-phase response|positive regulation of cell population proliferation|external side of plasma membrane|positive regulation of activation of Janus kinase activity|vascular endothelial growth factor production|apical plasma membrane|cytokine-mediated signaling pathway|enzyme binding|cytokine binding|interleukin-11 binding|interleukin-6 binding|endocrine pancreas development|positive regulation of chemokine production|positive regulation of interleukin-6 production|response to cytokine|interleukin-11-mediated signaling pathway|positive regulation of tyrosine phosphorylation of STAT protein|protein homodimerization activity|receptor complex|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|defense response to Gram-negative bacterium|interleukin-6-mediated signaling pathway|ciliary neurotrophic factor receptor complex|ciliary neurotrophic factor binding|ciliary neurotrophic factor-mediated signaling pathway|positive regulation of glomerular mesangial cell proliferation|T-helper 17 cell lineage commitment|extrinsic apoptotic signaling pathway "hsa01521,hsa04060,hsa04061,hsa04066,hsa04151,hsa04630,hsa04640,hsa04659,hsa04932,hsa05163,hsa05171,hsa05200" EGFR tyrosine kinase inhibitor resistance|Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|HIF-1 signaling pathway|PI3K-Akt signaling pathway|JAK-STAT signaling pathway|Hematopoietic cell lineage|Th17 cell differentiation|Non-alcoholic fatty liver disease|Human cytomegalovirus infection|Coronavirus disease - COVID-19|Pathways in cancer IL6ST 5318.87125 6077.057489 4560.685011 0.750475871 -0.414122407 0.085595513 1 35.74577196 26.37743688 3572 interleukin 6 cytokine family signal transducer "GO:0002675,GO:0002821,GO:0004896,GO:0004897,GO:0004915,GO:0004921,GO:0004923,GO:0004924,GO:0005127,GO:0005138,GO:0005515,GO:0005576,GO:0005886,GO:0005896,GO:0005900,GO:0005977,GO:0008284,GO:0009897,GO:0010575,GO:0010613,GO:0016020,GO:0016032,GO:0019221,GO:0019838,GO:0019955,GO:0019970,GO:0019981,GO:0030425,GO:0034097,GO:0038154,GO:0038165,GO:0042102,GO:0042531,GO:0042802,GO:0043025,GO:0043066,GO:0043235,GO:0045509,GO:0045669,GO:0045747,GO:0048711,GO:0048861,GO:0060576,GO:0070062,GO:0070102,GO:0070106,GO:0070110,GO:0070120,GO:0070757" positive regulation of acute inflammatory response|positive regulation of adaptive immune response|cytokine receptor activity|ciliary neurotrophic factor receptor activity|interleukin-6 receptor activity|interleukin-11 receptor activity|leukemia inhibitory factor receptor activity|oncostatin-M receptor activity|ciliary neurotrophic factor receptor binding|interleukin-6 receptor binding|protein binding|extracellular region|plasma membrane|interleukin-6 receptor complex|oncostatin-M receptor complex|glycogen metabolic process|positive regulation of cell population proliferation|external side of plasma membrane|positive regulation of vascular endothelial growth factor production|positive regulation of cardiac muscle hypertrophy|membrane|viral process|cytokine-mediated signaling pathway|growth factor binding|cytokine binding|interleukin-11 binding|interleukin-6 binding|dendrite|response to cytokine|interleukin-11-mediated signaling pathway|oncostatin-M-mediated signaling pathway|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|neuronal cell body|negative regulation of apoptotic process|receptor complex|interleukin-27 receptor activity|positive regulation of osteoblast differentiation|positive regulation of Notch signaling pathway|positive regulation of astrocyte differentiation|leukemia inhibitory factor signaling pathway|intestinal epithelial cell development|extracellular exosome|interleukin-6-mediated signaling pathway|interleukin-27-mediated signaling pathway|ciliary neurotrophic factor receptor complex|ciliary neurotrophic factor-mediated signaling pathway|interleukin-35-mediated signaling pathway "hsa04060,hsa04061,hsa04550,hsa04630,hsa04659,hsa05167,hsa05171,hsa05200,hsa05203" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Signaling pathways regulating pluripotency of stem cells|JAK-STAT signaling pathway|Th17 cell differentiation|Kaposi sarcoma-associated herpesvirus infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis IL7 117.7755888 114.4455271 121.1056505 1.058194702 0.0816051 0.87225857 1 1.789029713 1.8614626 3574 interleukin 7 "GO:0001961,GO:0002360,GO:0005125,GO:0005139,GO:0005515,GO:0005576,GO:0005615,GO:0006959,GO:0007267,GO:0008083,GO:0008284,GO:0009887,GO:0019221,GO:0030890,GO:0032722,GO:0038111,GO:0043066,GO:0043086,GO:0045453,GO:0045579,GO:0045582,GO:0046622,GO:0048873,GO:0050730,GO:0062023,GO:2001240" positive regulation of cytokine-mediated signaling pathway|T cell lineage commitment|cytokine activity|interleukin-7 receptor binding|protein binding|extracellular region|extracellular space|humoral immune response|cell-cell signaling|growth factor activity|positive regulation of cell population proliferation|animal organ morphogenesis|cytokine-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of chemokine production|interleukin-7-mediated signaling pathway|negative regulation of apoptotic process|negative regulation of catalytic activity|bone resorption|positive regulation of B cell differentiation|positive regulation of T cell differentiation|positive regulation of organ growth|homeostasis of number of cells within a tissue|regulation of peptidyl-tyrosine phosphorylation|collagen-containing extracellular matrix|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa04060,hsa04151,hsa04630,hsa04640,hsa05200" Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|JAK-STAT signaling pathway|Hematopoietic cell lineage|Pathways in cancer IL7R 5736.21108 6082.259558 5390.162601 0.886210552 -0.17427859 0.470782541 1 70.8113032 61.70362552 3575 interleukin 7 receptor "GO:0000018,GO:0000902,GO:0001915,GO:0003823,GO:0004896,GO:0004917,GO:0005515,GO:0005576,GO:0005654,GO:0005829,GO:0005886,GO:0006955,GO:0007165,GO:0007166,GO:0008284,GO:0008361,GO:0009897,GO:0010628,GO:0016021,GO:0030217,GO:0030665,GO:0033089,GO:0038111,GO:0042100,GO:0048535,GO:0048872,GO:0050830,GO:0061024,GO:0070233,GO:1904894" regulation of DNA recombination|cell morphogenesis|negative regulation of T cell mediated cytotoxicity|antigen binding|cytokine receptor activity|interleukin-7 receptor activity|protein binding|extracellular region|nucleoplasm|cytosol|plasma membrane|immune response|signal transduction|cell surface receptor signaling pathway|positive regulation of cell population proliferation|regulation of cell size|external side of plasma membrane|positive regulation of gene expression|integral component of membrane|T cell differentiation|clathrin-coated vesicle membrane|positive regulation of T cell differentiation in thymus|interleukin-7-mediated signaling pathway|B cell proliferation|lymph node development|homeostasis of number of cells|defense response to Gram-positive bacterium|membrane organization|negative regulation of T cell apoptotic process|positive regulation of receptor signaling pathway via STAT "hsa04060,hsa04068,hsa04151,hsa04630,hsa04640,hsa05200,hsa05340" Cytokine-cytokine receptor interaction|FoxO signaling pathway|PI3K-Akt signaling pathway|JAK-STAT signaling pathway|Hematopoietic cell lineage|Pathways in cancer|Primary immunodeficiency ILF2 5091.996741 4789.025102 5394.968381 1.12652748 0.171882507 0.474457884 1 136.6015328 151.3103171 3608 interleukin enhancer binding factor 2 "GO:0003677,GO:0003723,GO:0003725,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005730,GO:0016020,GO:0035580,GO:0043312,GO:0045893,GO:1904724,GO:1904813,GO:1990904" "DNA binding|RNA binding|double-stranded RNA binding|protein binding|extracellular region|nucleus|nucleoplasm|nucleolus|membrane|specific granule lumen|neutrophil degranulation|positive regulation of transcription, DNA-templated|tertiary granule lumen|ficolin-1-rich granule lumen|ribonucleoprotein complex" ILF3 5812.079462 5840.883537 5783.275387 0.990137083 -0.014299817 0.953578139 1 39.78014539 38.72869567 3609 interleukin enhancer binding factor 3 "GO:0003677,GO:0003723,GO:0003725,GO:0003727,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0006468,GO:0016020,GO:0017148,GO:0035925,GO:0045071,GO:0045892,GO:0045893,GO:0051607,GO:1990904" "DNA binding|RNA binding|double-stranded RNA binding|single-stranded RNA binding|protein binding|extracellular region|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|protein phosphorylation|membrane|negative regulation of translation|mRNA 3'-UTR AU-rich region binding|negative regulation of viral genome replication|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|defense response to virus|ribonucleoprotein complex" other ILK 5275.434104 4747.408546 5803.459662 1.222447911 0.289772993 0.228582357 1 123.2897658 148.1933 3611 integrin linked kinase "GO:0000902,GO:0001725,GO:0001934,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0005886,GO:0005925,GO:0006468,GO:0007160,GO:0007229,GO:0009967,GO:0016020,GO:0019901,GO:0030017,GO:0030027,GO:0033209,GO:0034329,GO:0034446,GO:0042327,GO:0045893,GO:0070527,GO:0090263,GO:0106310,GO:0106311,GO:1900026,GO:1901224" "cell morphogenesis|stress fiber|positive regulation of protein phosphorylation|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleoplasm|cytosol|plasma membrane|focal adhesion|protein phosphorylation|cell-matrix adhesion|integrin-mediated signaling pathway|positive regulation of signal transduction|membrane|protein kinase binding|sarcomere|lamellipodium|tumor necrosis factor-mediated signaling pathway|cell junction assembly|substrate adhesion-dependent cell spreading|positive regulation of phosphorylation|positive regulation of transcription, DNA-templated|platelet aggregation|positive regulation of canonical Wnt signaling pathway|protein serine kinase activity|protein threonine kinase activity|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of NIK/NF-kappaB signaling" "hsa03320,hsa04360,hsa04510,hsa05100,hsa05131,hsa05213" PPAR signaling pathway|Axon guidance|Focal adhesion|Bacterial invasion of epithelial cells|Shigellosis|Endometrial cancer ILKAP 498.9060663 531.651494 466.1606387 0.876816192 -0.189653654 0.490621637 1 19.86923186 17.13013627 80895 ILK associated serine/threonine phosphatase "GO:0004724,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006470,GO:0046872,GO:0106306,GO:0106307" magnesium-dependent protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|cytosol|protein dephosphorylation|metal ion binding|protein serine phosphatase activity|protein threonine phosphatase activity ILRUN 2087.841131 2062.100315 2113.581947 1.024965629 0.035575532 0.882375031 1 24.06001396 24.24802414 64771 inflammation and lipid regulator with UBA-like and NBR1-like domains "GO:0000407,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0016236,GO:0016607,GO:0032480,GO:0032720,GO:0043130,GO:0043392,GO:0045087,GO:0050687,GO:1900181" phagophore assembly site|protein binding|nucleus|cytoplasm|centrosome|cytosol|macroautophagy|nuclear speck|negative regulation of type I interferon production|negative regulation of tumor necrosis factor production|ubiquitin binding|negative regulation of DNA binding|innate immune response|negative regulation of defense response to virus|negative regulation of protein localization to nucleus ILVBL 535.5935389 523.328183 547.8588949 1.046874433 0.066088409 0.812162641 1 9.785936681 10.07321662 10994 ilvB acetolactate synthase like "GO:0000287,GO:0001561,GO:0003674,GO:0003984,GO:0005515,GO:0005789,GO:0005948,GO:0009097,GO:0009099,GO:0016020,GO:0016021,GO:0016829,GO:0030976,GO:0050660" magnesium ion binding|fatty acid alpha-oxidation|molecular_function|acetolactate synthase activity|protein binding|endoplasmic reticulum membrane|acetolactate synthase complex|isoleucine biosynthetic process|valine biosynthetic process|membrane|integral component of membrane|lyase activity|thiamine pyrophosphate binding|flavin adenine dinucleotide binding IMMP1L 87.42997907 87.39476614 87.465192 1.000805836 0.001162108 1 1 3.57402149 3.517046962 196294 inner mitochondrial membrane peptidase subunit 1 "GO:0003674,GO:0005739,GO:0006627,GO:0008150,GO:0008236,GO:0042720" molecular_function|mitochondrion|protein processing involved in protein targeting to mitochondrion|biological_process|serine-type peptidase activity|mitochondrial inner membrane peptidase complex hsa03060 Protein export IMMP2L 64.81324598 61.38441908 68.24207288 1.111716522 0.15278896 0.804042625 1 0.088527865 0.096771 83943 inner mitochondrial membrane peptidase subunit 2 "GO:0001541,GO:0004252,GO:0006465,GO:0006627,GO:0006801,GO:0006974,GO:0007283,GO:0007420,GO:0008015,GO:0008233,GO:0016021,GO:0022904,GO:0030728,GO:0033108,GO:0042720,GO:0061300" ovarian follicle development|serine-type endopeptidase activity|signal peptide processing|protein processing involved in protein targeting to mitochondrion|superoxide metabolic process|cellular response to DNA damage stimulus|spermatogenesis|brain development|blood circulation|peptidase activity|integral component of membrane|respiratory electron transport chain|ovulation|mitochondrial respiratory chain complex assembly|mitochondrial inner membrane peptidase complex|cerebellum vasculature development hsa03060 Protein export IMMT 2572.995333 2333.648339 2812.342327 1.205126874 0.269185039 0.25495802 1 45.83824909 54.31652408 10989 inner membrane mitochondrial protein "GO:0001401,GO:0003723,GO:0005515,GO:0005739,GO:0005743,GO:0005758,GO:0007007,GO:0016020,GO:0042407,GO:0051560,GO:0061617,GO:0140275" SAM complex|RNA binding|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|inner mitochondrial membrane organization|membrane|cristae formation|mitochondrial calcium ion homeostasis|MICOS complex|MIB complex IMP3 554.1675034 544.1364606 564.1985462 1.036869585 0.052234447 0.85138037 1 25.65332405 26.15405069 55272 IMP U3 small nucleolar ribonucleoprotein 3 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0019843,GO:0030515,GO:0030684,GO:0032040,GO:0034457" RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|rRNA processing|rRNA binding|snoRNA binding|preribosome|small-subunit processome|Mpp10 complex hsa03008 Ribosome biogenesis in eukaryotes IMP4 1076.636368 1139.253201 1014.019534 0.890073894 -0.168002981 0.492823634 1 18.69039333 16.35745307 92856 IMP U3 small nucleolar ribonucleoprotein 4 "GO:0001650,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0030515,GO:0030684,GO:0032040,GO:0034457" fibrillar center|protein binding|nucleoplasm|nucleolus|rRNA processing|snoRNA binding|preribosome|small-subunit processome|Mpp10 complex hsa03008 Ribosome biogenesis in eukaryotes IMPA1 1111.961979 1032.090572 1191.833385 1.154775965 0.207612985 0.394868493 1 15.42878905 17.51865483 3612 inositol monophosphatase 1 "GO:0000287,GO:0005515,GO:0005737,GO:0005829,GO:0006020,GO:0006021,GO:0006661,GO:0006796,GO:0007165,GO:0008934,GO:0030145,GO:0031403,GO:0042802,GO:0042803,GO:0043647,GO:0046854,GO:0046855,GO:0052832,GO:0052833,GO:0052834" magnesium ion binding|protein binding|cytoplasm|cytosol|inositol metabolic process|inositol biosynthetic process|phosphatidylinositol biosynthetic process|phosphate-containing compound metabolic process|signal transduction|inositol monophosphate 1-phosphatase activity|manganese ion binding|lithium ion binding|identical protein binding|protein homodimerization activity|inositol phosphate metabolic process|phosphatidylinositol phosphorylation|inositol phosphate dephosphorylation|inositol monophosphate 3-phosphatase activity|inositol monophosphate 4-phosphatase activity|inositol monophosphate phosphatase activity "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system IMPA2 260.015995 240.3356069 279.6963832 1.163774219 0.218811192 0.51300849 1 7.346087985 8.406128727 3613 inositol monophosphatase 2 "GO:0005515,GO:0005737,GO:0005829,GO:0006020,GO:0006021,GO:0006796,GO:0007165,GO:0008934,GO:0042803,GO:0043647,GO:0046854,GO:0046855,GO:0046872,GO:0052832,GO:0052833" protein binding|cytoplasm|cytosol|inositol metabolic process|inositol biosynthetic process|phosphate-containing compound metabolic process|signal transduction|inositol monophosphate 1-phosphatase activity|protein homodimerization activity|inositol phosphate metabolic process|phosphatidylinositol phosphorylation|inositol phosphate dephosphorylation|metal ion binding|inositol monophosphate 3-phosphatase activity|inositol monophosphate 4-phosphatase activity "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system IMPACT 850.4690366 879.1497308 821.7883424 0.934753562 -0.097342031 0.70004004 1 11.3467002 10.42888522 55364 impact RWD domain protein "GO:0000122,GO:0001933,GO:0003674,GO:0003779,GO:0005515,GO:0005575,GO:0005737,GO:0005844,GO:0006446,GO:0006469,GO:0008150,GO:0031333,GO:0031953,GO:0034198,GO:0042149,GO:0045666,GO:0060548,GO:0070301,GO:0071264,GO:0071468,GO:0071494,GO:0072755,GO:0097201,GO:0140469,GO:1990138,GO:1990253" negative regulation of transcription by RNA polymerase II|negative regulation of protein phosphorylation|molecular_function|actin binding|protein binding|cellular_component|cytoplasm|polysome|regulation of translational initiation|negative regulation of protein kinase activity|biological_process|negative regulation of protein-containing complex assembly|negative regulation of protein autophosphorylation|cellular response to amino acid starvation|cellular response to glucose starvation|positive regulation of neuron differentiation|negative regulation of cell death|cellular response to hydrogen peroxide|positive regulation of translational initiation in response to starvation|cellular response to acidic pH|cellular response to UV-C|cellular response to benomyl|negative regulation of transcription from RNA polymerase II promoter in response to stress|GCN2-mediated signaling|neuron projection extension|cellular response to leucine starvation IMPDH1 1315.70066 1296.355698 1335.045623 1.029845146 0.042427421 0.862931355 1 26.04823832 26.37676085 3614 inosine monophosphate dehydrogenase 1 "GO:0000166,GO:0003676,GO:0003677,GO:0003723,GO:0003938,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0006177,GO:0006183,GO:0009168,GO:0034774,GO:0035578,GO:0043312,GO:0046872,GO:0055114,GO:1904813" nucleotide binding|nucleic acid binding|DNA binding|RNA binding|IMP dehydrogenase activity|extracellular region|nucleus|cytoplasm|cytosol|GMP biosynthetic process|GTP biosynthetic process|purine ribonucleoside monophosphate biosynthetic process|secretory granule lumen|azurophil granule lumen|neutrophil degranulation|metal ion binding|oxidation-reduction process|ficolin-1-rich granule lumen "hsa00230,hsa00983" Purine metabolism|Drug metabolism - other enzymes IMPDH2 4582.260064 4301.070991 4863.449137 1.130753049 0.177283886 0.458782944 1 133.2212732 148.1195985 3615 inosine monophosphate dehydrogenase 2 "GO:0000166,GO:0003677,GO:0003723,GO:0003938,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005778,GO:0005829,GO:0006177,GO:0006183,GO:0007623,GO:0009168,GO:0016020,GO:0034774,GO:0043312,GO:0046872,GO:0055114,GO:0070062,GO:1904813" nucleotide binding|DNA binding|RNA binding|IMP dehydrogenase activity|protein binding|extracellular region|nucleus|cytoplasm|peroxisomal membrane|cytosol|GMP biosynthetic process|GTP biosynthetic process|circadian rhythm|purine ribonucleoside monophosphate biosynthetic process|membrane|secretory granule lumen|neutrophil degranulation|metal ion binding|oxidation-reduction process|extracellular exosome|ficolin-1-rich granule lumen "hsa00230,hsa00983" Purine metabolism|Drug metabolism - other enzymes IMPG2 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.019944316 0.024155542 50939 interphotoreceptor matrix proteoglycan 2 "GO:0005201,GO:0005540,GO:0007601,GO:0008201,GO:0016021,GO:0031012,GO:0033165,GO:0042995,GO:0043235" extracellular matrix structural constituent|hyaluronic acid binding|visual perception|heparin binding|integral component of membrane|extracellular matrix|interphotoreceptor matrix|cell projection|receptor complex INAFM1 66.89407374 65.54607461 68.24207288 1.041131346 0.058152086 0.944061669 1 4.16933675 4.268189318 255783 InaF motif containing 1 "GO:0005246,GO:0016021" calcium channel regulator activity|integral component of membrane INAFM2 236.2003322 208.0827765 264.3178879 1.270253561 0.345116509 0.314571968 1 3.6445669 4.552055267 100505573 InaF motif containing 2 "GO:0005246,GO:0016021" calcium channel regulator activity|integral component of membrane INAVA 290.9353031 433.8525891 148.0180172 0.34117122 -1.551432143 1.75E-06 0.001141682 4.148703689 1.391733192 55765 innate immunity activator "GO:0000187,GO:0002221,GO:0002367,GO:0005515,GO:0005634,GO:0005737,GO:0031398,GO:0032494,GO:0032495,GO:0032731,GO:0032733,GO:0032755,GO:0032874,GO:0034334,GO:0043123,GO:0045087,GO:0060729,GO:0070431,GO:1903409" activation of MAPK activity|pattern recognition receptor signaling pathway|cytokine production involved in immune response|protein binding|nucleus|cytoplasm|positive regulation of protein ubiquitination|response to peptidoglycan|response to muramyl dipeptide|positive regulation of interleukin-1 beta production|positive regulation of interleukin-10 production|positive regulation of interleukin-6 production|positive regulation of stress-activated MAPK cascade|adherens junction maintenance|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|intestinal epithelial structure maintenance|nucleotide-binding oligomerization domain containing 2 signaling pathway|reactive oxygen species biosynthetic process INCA1 8.566115259 10.40413883 6.728091692 0.64667454 -0.628888283 0.669388466 1 0.245143385 0.155875235 388324 "inhibitor of CDK, cyclin A1 interacting protein 1" "GO:0004861,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008285,GO:0016604,GO:0030332,GO:0042802,GO:0044877,GO:0045736,GO:2001235" cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|negative regulation of cell population proliferation|nuclear body|cyclin binding|identical protein binding|protein-containing complex binding|negative regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of apoptotic signaling pathway INCENP 2868.482322 3000.553638 2736.411007 0.911968702 -0.132943781 0.574746895 1 24.72348817 22.16975311 3619 inner centromere protein "GO:0000070,GO:0000281,GO:0000775,GO:0000776,GO:0000777,GO:0000793,GO:0000800,GO:0000801,GO:0005515,GO:0005634,GO:0005654,GO:0005721,GO:0005819,GO:0005829,GO:0005874,GO:0007059,GO:0010032,GO:0010369,GO:0016572,GO:0016604,GO:0030496,GO:0032133,GO:0032991,GO:0043539,GO:0051257,GO:0051310,GO:0071902,GO:1902412,GO:1990385" "mitotic sister chromatid segregation|mitotic cytokinesis|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|condensed chromosome|lateral element|central element|protein binding|nucleus|nucleoplasm|pericentric heterochromatin|spindle|cytosol|microtubule|chromosome segregation|meiotic chromosome condensation|chromocenter|histone phosphorylation|nuclear body|midbody|chromosome passenger complex|protein-containing complex|protein serine/threonine kinase activator activity|meiotic spindle midzone assembly|metaphase plate congression|positive regulation of protein serine/threonine kinase activity|regulation of mitotic cytokinesis|meiotic spindle midzone" INF2 2304.249062 2192.152051 2416.346073 1.102271201 0.140479226 0.55299858 1 13.79124436 14.94731177 64423 inverted formin 2 "GO:0003779,GO:0030036,GO:0048471,GO:0090140" actin binding|actin cytoskeleton organization|perinuclear region of cytoplasm|regulation of mitochondrial fission ING1 393.8437715 372.46817 415.219373 1.114778138 0.156756615 0.594188415 1 4.836482157 5.301383372 3621 inhibitor of growth family member 1 "GO:0005515,GO:0005634,GO:0007049,GO:0008285,GO:0010941,GO:0030308,GO:0035064,GO:0045893,GO:0046872" "protein binding|nucleus|cell cycle|negative regulation of cell population proliferation|regulation of cell death|negative regulation of cell growth|methylated histone binding|positive regulation of transcription, DNA-templated|metal ion binding" ING2 187.1222422 156.0620824 218.182402 1.398048768 0.483414687 0.195567697 1 5.493896113 7.552207999 3622 inhibitor of growth family member 2 "GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0006325,GO:0006355,GO:0007141,GO:0007165,GO:0007283,GO:0007286,GO:0008285,GO:0016580,GO:0016602,GO:0030317,GO:0030511,GO:0031065,GO:0035064,GO:0035091,GO:0040008,GO:0044877,GO:0045893,GO:0046872,GO:0048133,GO:0072520,GO:1902166,GO:2000772,GO:2001020" "DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|plasma membrane|chromatin organization|regulation of transcription, DNA-templated|male meiosis I|signal transduction|spermatogenesis|spermatid development|negative regulation of cell population proliferation|Sin3 complex|CCAAT-binding factor complex|flagellated sperm motility|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of histone deacetylation|methylated histone binding|phosphatidylinositol binding|regulation of growth|protein-containing complex binding|positive regulation of transcription, DNA-templated|metal ion binding|male germ-line stem cell asymmetric division|seminiferous tubule development|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of cellular senescence|regulation of response to DNA damage stimulus" ING3 286.1798275 309.0029231 263.3567319 0.852279096 -0.230602148 0.475712183 1 3.586541558 3.005584086 54556 inhibitor of growth family member 3 "GO:0000812,GO:0005654,GO:0032777,GO:0035064,GO:0035267,GO:0040008,GO:0043065,GO:0043967,GO:0043968,GO:0046872" Swr1 complex|nucleoplasm|Piccolo NuA4 histone acetyltransferase complex|methylated histone binding|NuA4 histone acetyltransferase complex|regulation of growth|positive regulation of apoptotic process|histone H4 acetylation|histone H2A acetylation|metal ion binding ING4 383.2364574 358.9427895 407.5301253 1.13536234 0.183152793 0.53550977 1 9.798525303 10.93871687 51147 inhibitor of growth family member 4 "GO:0000123,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006260,GO:0006473,GO:0006915,GO:0006978,GO:0007050,GO:0008285,GO:0035064,GO:0043065,GO:0043966,GO:0043981,GO:0043982,GO:0043983,GO:0043984,GO:0045111,GO:0045892,GO:0045893,GO:0045926,GO:0046872,GO:0070776" "histone acetyltransferase complex|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytosol|DNA replication|protein acetylation|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|cell cycle arrest|negative regulation of cell population proliferation|methylated histone binding|positive regulation of apoptotic process|histone H3 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K12 acetylation|histone H4-K16 acetylation|intermediate filament cytoskeleton|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of growth|metal ion binding|MOZ/MORF histone acetyltransferase complex" ING5 778.1011355 682.511507 873.690764 1.280111405 0.35626937 0.158347375 1 3.42946848 4.316639307 84289 inhibitor of growth family member 5 "GO:0000123,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006260,GO:0006473,GO:0008285,GO:0035064,GO:0043065,GO:0043966,GO:0043967,GO:0044154,GO:0045893,GO:0045926,GO:0046872,GO:0070776,GO:1901796,GO:2001235" "histone acetyltransferase complex|chromatin binding|protein binding|nucleus|nucleoplasm|chromosome|DNA replication|protein acetylation|negative regulation of cell population proliferation|methylated histone binding|positive regulation of apoptotic process|histone H3 acetylation|histone H4 acetylation|histone H3-K14 acetylation|positive regulation of transcription, DNA-templated|negative regulation of growth|metal ion binding|MOZ/MORF histone acetyltransferase complex|regulation of signal transduction by p53 class mediator|positive regulation of apoptotic signaling pathway" INHA 9.046693237 10.40413883 7.689247648 0.739056617 -0.436243205 0.791668951 1 0.410991686 0.298663345 3623 inhibin subunit alpha "GO:0001501,GO:0001541,GO:0001750,GO:0001917,GO:0005102,GO:0005125,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0007050,GO:0007165,GO:0007166,GO:0007267,GO:0008083,GO:0008584,GO:0010862,GO:0030154,GO:0030218,GO:0032689,GO:0034673,GO:0034711,GO:0042127,GO:0042326,GO:0042541,GO:0043025,GO:0043512,GO:0043513,GO:0044877,GO:0045578,GO:0045650,GO:0045786,GO:0046881,GO:0046882,GO:0051726,GO:0060395" skeletal system development|ovarian follicle development|photoreceptor outer segment|photoreceptor inner segment|signaling receptor binding|cytokine activity|hormone activity|protein binding|extracellular region|extracellular space|cytoplasm|cell cycle arrest|signal transduction|cell surface receptor signaling pathway|cell-cell signaling|growth factor activity|male gonad development|positive regulation of pathway-restricted SMAD protein phosphorylation|cell differentiation|erythrocyte differentiation|negative regulation of interferon-gamma production|inhibin-betaglycan-ActRII complex|inhibin binding|regulation of cell population proliferation|negative regulation of phosphorylation|hemoglobin biosynthetic process|neuronal cell body|inhibin A complex|inhibin B complex|protein-containing complex binding|negative regulation of B cell differentiation|negative regulation of macrophage differentiation|negative regulation of cell cycle|positive regulation of follicle-stimulating hormone secretion|negative regulation of follicle-stimulating hormone secretion|regulation of cell cycle|SMAD protein signal transduction hsa04060 Cytokine-cytokine receptor interaction INHBA 5489.25375 6033.360105 4945.147394 0.819634053 -0.286948171 0.233996339 1 39.69785969 31.99324298 3624 inhibin subunit beta A "GO:0000082,GO:0001541,GO:0001942,GO:0002244,GO:0005125,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0006357,GO:0006952,GO:0007050,GO:0007166,GO:0007267,GO:0007399,GO:0008083,GO:0008285,GO:0008584,GO:0009611,GO:0010628,GO:0010862,GO:0017046,GO:0021773,GO:0030154,GO:0030218,GO:0030308,GO:0032270,GO:0032689,GO:0032924,GO:0034711,GO:0035987,GO:0042326,GO:0042476,GO:0042493,GO:0042541,GO:0042701,GO:0042802,GO:0043509,GO:0043512,GO:0044877,GO:0045578,GO:0045648,GO:0045650,GO:0045786,GO:0045893,GO:0045944,GO:0046880,GO:0046881,GO:0046882,GO:0048333,GO:0048471,GO:0060021,GO:0060279,GO:0060395,GO:0061029,GO:0070699,GO:0071372,GO:0071397,GO:0097154,GO:0097191,GO:2001241" "G1/S transition of mitotic cell cycle|ovarian follicle development|hair follicle development|hematopoietic progenitor cell differentiation|cytokine activity|hormone activity|protein binding|extracellular region|extracellular space|regulation of transcription by RNA polymerase II|defense response|cell cycle arrest|cell surface receptor signaling pathway|cell-cell signaling|nervous system development|growth factor activity|negative regulation of cell population proliferation|male gonad development|response to wounding|positive regulation of gene expression|positive regulation of pathway-restricted SMAD protein phosphorylation|peptide hormone binding|striatal medium spiny neuron differentiation|cell differentiation|erythrocyte differentiation|negative regulation of cell growth|positive regulation of cellular protein metabolic process|negative regulation of interferon-gamma production|activin receptor signaling pathway|inhibin binding|endodermal cell differentiation|negative regulation of phosphorylation|odontogenesis|response to drug|hemoglobin biosynthetic process|progesterone secretion|identical protein binding|activin A complex|inhibin A complex|protein-containing complex binding|negative regulation of B cell differentiation|positive regulation of erythrocyte differentiation|negative regulation of macrophage differentiation|negative regulation of cell cycle|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of follicle-stimulating hormone secretion|positive regulation of follicle-stimulating hormone secretion|negative regulation of follicle-stimulating hormone secretion|mesodermal cell differentiation|perinuclear region of cytoplasm|roof of mouth development|positive regulation of ovulation|SMAD protein signal transduction|eyelid development in camera-type eye|type II activin receptor binding|cellular response to follicle-stimulating hormone stimulus|cellular response to cholesterol|GABAergic neuron differentiation|extrinsic apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa04060,hsa04350,hsa04550" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells INHBB 22.26007242 16.64662212 27.87352272 1.674425149 0.743665885 0.375505823 1 0.277105311 0.456227822 3625 inhibin subunit beta B "GO:0001541,GO:0005125,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0006952,GO:0008083,GO:0009267,GO:0009611,GO:0010862,GO:0030154,GO:0032686,GO:0032869,GO:0032924,GO:0042803,GO:0044320,GO:0044650,GO:0045444,GO:0046676,GO:0046789,GO:0046881,GO:0046882,GO:0048471,GO:0048599,GO:0060279,GO:0060395,GO:0071944,GO:2001235" ovarian follicle development|cytokine activity|hormone activity|protein binding|extracellular region|extracellular space|defense response|growth factor activity|cellular response to starvation|response to wounding|positive regulation of pathway-restricted SMAD protein phosphorylation|cell differentiation|negative regulation of hepatocyte growth factor production|cellular response to insulin stimulus|activin receptor signaling pathway|protein homodimerization activity|cellular response to leptin stimulus|adhesion of symbiont to host cell|fat cell differentiation|negative regulation of insulin secretion|host cell surface receptor binding|positive regulation of follicle-stimulating hormone secretion|negative regulation of follicle-stimulating hormone secretion|perinuclear region of cytoplasm|oocyte development|positive regulation of ovulation|SMAD protein signal transduction|cell periphery|positive regulation of apoptotic signaling pathway "hsa04060,hsa04350,hsa04550" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells INHBC 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.052022152 0.015751647 3626 inhibin subunit beta C "GO:0005125,GO:0005160,GO:0005179,GO:0005576,GO:0005615,GO:0008083,GO:0010862,GO:0060395" cytokine activity|transforming growth factor beta receptor binding|hormone activity|extracellular region|extracellular space|growth factor activity|positive regulation of pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction "hsa04060,hsa04350,hsa04550" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells INHBE 32.29748974 53.06110801 11.53387147 0.217369593 -2.201777951 0.002884166 0.349035077 1.151127566 0.246033036 83729 inhibin subunit beta E "GO:0005125,GO:0005179,GO:0005615,GO:0008083,GO:0010862,GO:0060395,GO:0062023" cytokine activity|hormone activity|extracellular space|growth factor activity|positive regulation of pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction|collagen-containing extracellular matrix "hsa04060,hsa04350,hsa04550" Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells INIP 640.0463081 704.3601985 575.7324176 0.817383519 -0.290914941 0.26338147 1 8.639487299 6.943605296 58493 INTS3 and NABP interacting protein "GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006974,GO:0010212,GO:0035861,GO:0070876" protein binding|nucleus|nucleoplasm|DNA repair|cellular response to DNA damage stimulus|response to ionizing radiation|site of double-strand break|SOSS complex INKA1 23.26085734 17.687036 28.83467868 1.63027195 0.705112644 0.393311735 1 0.990477024 1.587726307 389119 inka box actin regulator 1 "GO:0005515,GO:0005634,GO:0005737,GO:0019901,GO:0030291,GO:0071901" protein binding|nucleus|cytoplasm|protein kinase binding|protein serine/threonine kinase inhibitor activity|negative regulation of protein serine/threonine kinase activity INKA2 36.46920611 36.41448589 36.52392633 1.003005409 0.004329387 1 1 0.314818433 0.310480698 55924 inka box actin regulator 2 "GO:0005634,GO:0005654,GO:0019901,GO:0030291,GO:0071901" nucleus|nucleoplasm|protein kinase binding|protein serine/threonine kinase inhibitor activity|negative regulation of protein serine/threonine kinase activity INO80 826.8112752 951.9787026 701.6438479 0.737037337 -0.440190389 0.078932772 1 6.290126742 4.558480107 54617 INO80 complex ATPase subunit "GO:0000070,GO:0000724,GO:0003677,GO:0003779,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005819,GO:0005829,GO:0005874,GO:0006281,GO:0006302,GO:0006338,GO:0006351,GO:0008094,GO:0010571,GO:0016579,GO:0016604,GO:0016887,GO:0030307,GO:0031011,GO:0032508,GO:0034644,GO:0042393,GO:0042766,GO:0043014,GO:0043044,GO:0043138,GO:0043618,GO:0045944,GO:0051225,GO:0051301,GO:0070914,GO:0071479,GO:2000045" "mitotic sister chromatid segregation|double-strand break repair via homologous recombination|DNA binding|actin binding|protein binding|ATP binding|nucleus|nucleoplasm|spindle|cytosol|microtubule|DNA repair|double-strand break repair|chromatin remodeling|transcription, DNA-templated|DNA-dependent ATPase activity|positive regulation of nuclear cell cycle DNA replication|protein deubiquitination|nuclear body|ATPase activity|positive regulation of cell growth|Ino80 complex|DNA duplex unwinding|cellular response to UV|histone binding|nucleosome mobilization|alpha-tubulin binding|ATP-dependent chromatin remodeling|3'-5' DNA helicase activity|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription by RNA polymerase II|spindle assembly|cell division|UV-damage excision repair|cellular response to ionizing radiation|regulation of G1/S transition of mitotic cell cycle" chromosome_remodelling_factor INO80B 283.5737624 316.2858203 250.8617045 0.793148755 -0.334336627 0.299552267 1 14.29262737 11.14648399 83444 INO80 complex subunit B "GO:0005515,GO:0005654,GO:0005730,GO:0006281,GO:0006310,GO:0016579,GO:0031011,GO:0043044,GO:0046872" protein binding|nucleoplasm|nucleolus|DNA repair|DNA recombination|protein deubiquitination|Ino80 complex|ATP-dependent chromatin remodeling|metal ion binding INO80C 141.4377662 130.0517353 152.823797 1.175100022 0.232783561 0.583450441 1 3.41902566 3.950466407 125476 INO80 complex subunit C "GO:0003674,GO:0005515,GO:0005654,GO:0006281,GO:0006310,GO:0006338,GO:0008150,GO:0016579,GO:0031011,GO:0071339" molecular_function|protein binding|nucleoplasm|DNA repair|DNA recombination|chromatin remodeling|biological_process|protein deubiquitination|Ino80 complex|MLL1 complex INO80D 389.538077 423.4484502 355.6277037 0.839837065 -0.251818634 0.38930397 1 1.385996046 1.144532706 54891 INO80 complex subunit D "GO:0005634,GO:0005654,GO:0006281,GO:0006310,GO:0016579" nucleus|nucleoplasm|DNA repair|DNA recombination|protein deubiquitination INO80E 1068.20423 1094.515405 1041.893056 0.951921784 -0.071085058 0.774227732 1 16.76586553 15.69272711 283899 INO80 complex subunit E "GO:0005515,GO:0005654,GO:0005730,GO:0006281,GO:0006310,GO:0006338,GO:0016579,GO:0031011" protein binding|nucleoplasm|nucleolus|DNA repair|DNA recombination|chromatin remodeling|protein deubiquitination|Ino80 complex INPP1 513.3781259 495.2370081 531.5192437 1.073262367 0.102002797 0.712549608 1 11.15185186 11.76858022 3628 inositol polyphosphate-1-phosphatase "GO:0004441,GO:0005515,GO:0005829,GO:0006796,GO:0007165,GO:0043647,GO:0046854,GO:0046855,GO:0046872" "inositol-1,4-bisphosphate 1-phosphatase activity|protein binding|cytosol|phosphate-containing compound metabolic process|signal transduction|inositol phosphate metabolic process|phosphatidylinositol phosphorylation|inositol phosphate dephosphorylation|metal ion binding" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP4A 1073.218216 1074.747541 1071.688891 0.997154076 -0.004111654 0.990914947 1 3.144588868 3.083168924 3631 inositol polyphosphate-4-phosphatase type I A "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006661,GO:0007165,GO:0014069,GO:0016311,GO:0016316,GO:0031901,GO:0031965,GO:0034597,GO:0036092,GO:0043647,GO:0055038" "protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|signal transduction|postsynaptic density|dephosphorylation|phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|early endosome membrane|nuclear membrane|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity|phosphatidylinositol-3-phosphate biosynthetic process|inositol phosphate metabolic process|recycling endosome membrane" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP4B 502.236128 417.2059669 587.2662891 1.407617186 0.493255033 0.070839622 1 1.736779693 2.40381185 8821 inositol polyphosphate-4-phosphatase type II B "GO:0005515,GO:0005737,GO:0005829,GO:0006661,GO:0007165,GO:0016311,GO:0016316,GO:0034597,GO:0036092,GO:0043647" "protein binding|cytoplasm|cytosol|phosphatidylinositol biosynthetic process|signal transduction|dephosphorylation|phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity|phosphatidylinositol-3-phosphate biosynthetic process|inositol phosphate metabolic process" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP5A 283.083738 240.3356069 325.8318691 1.355736977 0.439077312 0.172618148 1 1.866997034 2.488801431 3632 inositol polyphosphate-5-phosphatase A "GO:0004445,GO:0005515,GO:0005886,GO:0016020,GO:0030425,GO:0042731,GO:0043647,GO:0046855,GO:0046856,GO:0048016,GO:0052658,GO:0052659,GO:1901215" "inositol-polyphosphate 5-phosphatase activity|protein binding|plasma membrane|membrane|dendrite|PH domain binding|inositol phosphate metabolic process|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|inositol phosphate-mediated signaling|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity|negative regulation of neuron death" "hsa00562,hsa04070,hsa04910" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Insulin signaling pathway INPP5B 456.635326 481.7116277 431.5590242 0.895886666 -0.158611858 0.574073513 1 4.875415175 4.294729905 3633 inositol polyphosphate-5-phosphatase B "GO:0001701,GO:0004439,GO:0005515,GO:0005793,GO:0005794,GO:0005829,GO:0005886,GO:0007165,GO:0007283,GO:0016020,GO:0016021,GO:0030317,GO:0030670,GO:0031901,GO:0043647,GO:0046855,GO:0046856,GO:0046872,GO:0051056,GO:0052658,GO:0070613" "in utero embryonic development|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|plasma membrane|signal transduction|spermatogenesis|membrane|integral component of membrane|flagellated sperm motility|phagocytic vesicle membrane|early endosome membrane|inositol phosphate metabolic process|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|metal ion binding|regulation of small GTPase mediated signal transduction|inositol-1,4,5-trisphosphate 5-phosphatase activity|regulation of protein processing" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP5E 533.0717622 520.2069413 545.936583 1.049460397 0.069647725 0.8020604 1 8.124813684 8.383987914 56623 inositol polyphosphate-5-phosphatase E "GO:0001726,GO:0004439,GO:0004445,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0005886,GO:0005925,GO:0005929,GO:0005930,GO:0006661,GO:0008150,GO:0014067,GO:0016314,GO:0017148,GO:0032580,GO:0046855,GO:0046856,GO:1903565" "ruffle|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|nucleus|nucleoplasm|Golgi apparatus|cytosol|plasma membrane|focal adhesion|cilium|axoneme|phosphatidylinositol biosynthetic process|biological_process|negative regulation of phosphatidylinositol 3-kinase signaling|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|negative regulation of translation|Golgi cisterna membrane|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|negative regulation of protein localization to cilium" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP5F 709.7250845 716.8451651 702.6050038 0.980134955 -0.028947687 0.915547408 1 5.488767426 5.289710272 22876 inositol polyphosphate-5-phosphatase F "GO:0001921,GO:0005515,GO:0005769,GO:0005905,GO:0006661,GO:0008344,GO:0008934,GO:0014898,GO:0030424,GO:0030425,GO:0031161,GO:0031901,GO:0033137,GO:0034595,GO:0034596,GO:0042532,GO:0042803,GO:0043025,GO:0043231,GO:0043812,GO:0045334,GO:0046856,GO:0048015,GO:0048681,GO:0051896,GO:0052832,GO:0052833,GO:0055037,GO:0072583,GO:2000145,GO:2001135" positive regulation of receptor recycling|protein binding|early endosome|clathrin-coated pit|phosphatidylinositol biosynthetic process|adult locomotory behavior|inositol monophosphate 1-phosphatase activity|cardiac muscle hypertrophy in response to stress|axon|dendrite|phosphatidylinositol catabolic process|early endosome membrane|negative regulation of peptidyl-serine phosphorylation|phosphatidylinositol phosphate 5-phosphatase activity|phosphatidylinositol phosphate 4-phosphatase activity|negative regulation of tyrosine phosphorylation of STAT protein|protein homodimerization activity|neuronal cell body|intracellular membrane-bounded organelle|phosphatidylinositol-4-phosphate phosphatase activity|clathrin-coated endocytic vesicle|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|negative regulation of axon regeneration|regulation of protein kinase B signaling|inositol monophosphate 3-phosphatase activity|inositol monophosphate 4-phosphatase activity|recycling endosome|clathrin-dependent endocytosis|regulation of cell motility|regulation of endocytic recycling "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP5J 67.00793021 81.15228285 52.86357758 0.651412083 -0.618357615 0.253344267 1 0.981851776 0.628887436 27124 inositol polyphosphate-5-phosphatase J "GO:0001726,GO:0004439,GO:0004445,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0006661,GO:0010977,GO:0017124,GO:0019898,GO:0030426,GO:0031115,GO:0033137,GO:0034485,GO:0043198,GO:0043647,GO:0046855,GO:0046856,GO:0052658,GO:0052659" "ruffle|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|protein binding|cytoplasm|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|negative regulation of neuron projection development|SH3 domain binding|extrinsic component of membrane|growth cone|negative regulation of microtubule polymerization|negative regulation of peptidyl-serine phosphorylation|phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity|dendritic shaft|inositol phosphate metabolic process|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity" hsa00562 Inositol phosphate metabolism INPP5K 524.1087429 600.3188103 447.8986755 0.746101351 -0.422556474 0.117911149 1 10.30820835 7.562270245 51763 inositol polyphosphate-5-phosphatase K "GO:0001701,GO:0001726,GO:0001933,GO:0004439,GO:0004445,GO:0005000,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005802,GO:0005829,GO:0005886,GO:0005979,GO:0006469,GO:0006661,GO:0007186,GO:0010801,GO:0010829,GO:0016020,GO:0016311,GO:0016312,GO:0030036,GO:0032587,GO:0032869,GO:0032870,GO:0033137,GO:0034485,GO:0034594,GO:0034595,GO:0035305,GO:0035810,GO:0042577,GO:0042593,GO:0043005,GO:0043407,GO:0043922,GO:0045719,GO:0045869,GO:0045892,GO:0045893,GO:0046030,GO:0046627,GO:0046855,GO:0046856,GO:0048471,GO:0051497,GO:0051898,GO:0051926,GO:0052658,GO:0052659,GO:0071320,GO:0071356,GO:0071364,GO:0072659,GO:0090315,GO:0097178,GO:2000466,GO:2001153" "in utero embryonic development|ruffle|negative regulation of protein phosphorylation|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|vasopressin receptor activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum|trans-Golgi network|cytosol|plasma membrane|regulation of glycogen biosynthetic process|negative regulation of protein kinase activity|phosphatidylinositol biosynthetic process|G protein-coupled receptor signaling pathway|negative regulation of peptidyl-threonine phosphorylation|negative regulation of glucose transmembrane transport|membrane|dephosphorylation|inositol bisphosphate phosphatase activity|actin cytoskeleton organization|ruffle membrane|cellular response to insulin stimulus|cellular response to hormone stimulus|negative regulation of peptidyl-serine phosphorylation|phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity|phosphatidylinositol trisphosphate phosphatase activity|phosphatidylinositol phosphate 5-phosphatase activity|negative regulation of dephosphorylation|positive regulation of urine volume|lipid phosphatase activity|glucose homeostasis|neuron projection|negative regulation of MAP kinase activity|negative regulation by host of viral transcription|negative regulation of glycogen biosynthetic process|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|inositol trisphosphate phosphatase activity|negative regulation of insulin receptor signaling pathway|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|perinuclear region of cytoplasm|negative regulation of stress fiber assembly|negative regulation of protein kinase B signaling|negative regulation of calcium ion transport|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity|cellular response to cAMP|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|protein localization to plasma membrane|negative regulation of protein targeting to membrane|ruffle assembly|negative regulation of glycogen (starch) synthase activity|positive regulation of renal water transport" hsa00562 Inositol phosphate metabolism INPPL1 3816.900562 3801.672327 3832.128797 1.008011335 0.011511861 0.962594461 1 38.498722 38.15776307 3636 inositol polyphosphate phosphatase like 1 "GO:0001958,GO:0002376,GO:0003779,GO:0005515,GO:0005634,GO:0005794,GO:0005829,GO:0005856,GO:0005886,GO:0006006,GO:0006661,GO:0006897,GO:0007015,GO:0007155,GO:0008285,GO:0009791,GO:0010629,GO:0016607,GO:0016787,GO:0017124,GO:0019221,GO:0030027,GO:0030175,GO:0032868,GO:0042169,GO:0043647,GO:0046856,GO:0097178" endochondral ossification|immune system process|actin binding|protein binding|nucleus|Golgi apparatus|cytosol|cytoskeleton|plasma membrane|glucose metabolic process|phosphatidylinositol biosynthetic process|endocytosis|actin filament organization|cell adhesion|negative regulation of cell population proliferation|post-embryonic development|negative regulation of gene expression|nuclear speck|hydrolase activity|SH3 domain binding|cytokine-mediated signaling pathway|lamellipodium|filopodium|response to insulin|SH2 domain binding|inositol phosphate metabolic process|phosphatidylinositol dephosphorylation|ruffle assembly "hsa00562,hsa04070,hsa04662,hsa04666,hsa04910" Inositol phosphate metabolism|Phosphatidylinositol signaling system|B cell receptor signaling pathway|Fc gamma R-mediated phagocytosis|Insulin signaling pathway INSC 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.015457956 0.042124253 387755 INSC spindle orientation adaptor protein "GO:0000132,GO:0005515,GO:0005886,GO:0005938,GO:0007399,GO:0008093,GO:0008356,GO:0009786,GO:0019904,GO:0030154,GO:0030674,GO:0031647,GO:0032991,GO:0045176,GO:0045179" establishment of mitotic spindle orientation|protein binding|plasma membrane|cell cortex|nervous system development|cytoskeletal anchor activity|asymmetric cell division|regulation of asymmetric cell division|protein domain specific binding|cell differentiation|protein-macromolecule adaptor activity|regulation of protein stability|protein-containing complex|apical protein localization|apical cortex INSIG1 331.1509822 316.2858203 346.0161442 1.093998282 0.129610473 0.677922509 1 6.374468626 6.85696301 3638 insulin induced gene 1 "GO:0005515,GO:0005783,GO:0005789,GO:0006641,GO:0006695,GO:0008142,GO:0010894,GO:0016126,GO:0032869,GO:0032933,GO:0032937,GO:0036315,GO:0036316,GO:0042472,GO:0042474,GO:0042632,GO:0045599,GO:0045717,GO:0060021,GO:0060363,GO:0070862,GO:1901303" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|triglyceride metabolic process|cholesterol biosynthetic process|oxysterol binding|negative regulation of steroid biosynthetic process|sterol biosynthetic process|cellular response to insulin stimulus|SREBP signaling pathway|SREBP-SCAP-Insig complex|cellular response to sterol|SREBP-SCAP complex retention in endoplasmic reticulum|inner ear morphogenesis|middle ear morphogenesis|cholesterol homeostasis|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|roof of mouth development|cranial suture morphogenesis|negative regulation of protein exit from endoplasmic reticulum|negative regulation of cargo loading into COPII-coated vesicle INSIG2 500.9082506 432.8121752 569.0043259 1.314668021 0.394698538 0.148642041 1 6.988922939 9.034362856 51141 insulin induced gene 2 "GO:0005515,GO:0005783,GO:0005789,GO:0006695,GO:0008142,GO:0016126,GO:0032869,GO:0032933,GO:0032937,GO:0036316" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol biosynthetic process|oxysterol binding|sterol biosynthetic process|cellular response to insulin stimulus|SREBP signaling pathway|SREBP-SCAP-Insig complex|SREBP-SCAP complex retention in endoplasmic reticulum INSR 201.5295207 181.0320156 222.0270258 1.226451714 0.294490436 0.420512335 1 1.020097767 1.23016518 3643 insulin receptor "GO:0000187,GO:0001540,GO:0001934,GO:0002092,GO:0003007,GO:0004713,GO:0004714,GO:0005009,GO:0005159,GO:0005515,GO:0005524,GO:0005525,GO:0005635,GO:0005764,GO:0005770,GO:0005886,GO:0005887,GO:0005899,GO:0005901,GO:0005975,GO:0006355,GO:0006468,GO:0006898,GO:0007169,GO:0007186,GO:0007275,GO:0007612,GO:0007613,GO:0008284,GO:0008286,GO:0009897,GO:0010008,GO:0014068,GO:0016020,GO:0018108,GO:0019087,GO:0019904,GO:0030335,GO:0030424,GO:0031981,GO:0031994,GO:0031995,GO:0032147,GO:0032148,GO:0032590,GO:0032809,GO:0032869,GO:0033674,GO:0038024,GO:0042593,GO:0043235,GO:0043243,GO:0043410,GO:0043548,GO:0043559,GO:0043560,GO:0044877,GO:0045429,GO:0045725,GO:0045821,GO:0045840,GO:0045995,GO:0046326,GO:0046777,GO:0048639,GO:0051425,GO:0051897,GO:0060267,GO:0070062,GO:0097062,GO:0097242,GO:0150104,GO:1990535" "activation of MAPK activity|amyloid-beta binding|positive regulation of protein phosphorylation|positive regulation of receptor internalization|heart morphogenesis|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|insulin-activated receptor activity|insulin-like growth factor receptor binding|protein binding|ATP binding|GTP binding|nuclear envelope|lysosome|late endosome|plasma membrane|integral component of plasma membrane|insulin receptor complex|caveola|carbohydrate metabolic process|regulation of transcription, DNA-templated|protein phosphorylation|receptor-mediated endocytosis|transmembrane receptor protein tyrosine kinase signaling pathway|G protein-coupled receptor signaling pathway|multicellular organism development|learning|memory|positive regulation of cell population proliferation|insulin receptor signaling pathway|external side of plasma membrane|endosome membrane|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|peptidyl-tyrosine phosphorylation|transformation of host cell by virus|protein domain specific binding|positive regulation of cell migration|axon|nuclear lumen|insulin-like growth factor I binding|insulin-like growth factor II binding|activation of protein kinase activity|activation of protein kinase B activity|dendrite membrane|neuronal cell body membrane|cellular response to insulin stimulus|positive regulation of kinase activity|cargo receptor activity|glucose homeostasis|receptor complex|positive regulation of protein-containing complex disassembly|positive regulation of MAPK cascade|phosphatidylinositol 3-kinase binding|insulin binding|insulin receptor substrate binding|protein-containing complex binding|positive regulation of nitric oxide biosynthetic process|positive regulation of glycogen biosynthetic process|positive regulation of glycolytic process|positive regulation of mitotic nuclear division|regulation of embryonic development|positive regulation of glucose import|protein autophosphorylation|positive regulation of developmental growth|PTB domain binding|positive regulation of protein kinase B signaling|positive regulation of respiratory burst|extracellular exosome|dendritic spine maintenance|amyloid-beta clearance|transport across blood-brain barrier|neuron projection maintenance" "hsa04010,hsa04014,hsa04015,hsa04022,hsa04066,hsa04068,hsa04072,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04520,hsa04910,hsa04913,hsa04923,hsa04930,hsa04931,hsa04932,hsa04960,hsa05010" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adherens junction|Insulin signaling pathway|Ovarian steroidogenesis|Regulation of lipolysis in adipocytes|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|Aldosterone-regulated sodium reabsorption|Alzheimer disease INSYN2B 1835.288514 1487.791852 2182.785176 1.46713075 0.552997449 0.019803081 0.808379488 13.60766353 19.63014739 100131897 inhibitory synaptic factor family member 2B INTS1 2616.339243 2701.954853 2530.723632 0.936626913 -0.094453603 0.690474675 1 20.03311538 18.44957233 26173 integrator complex subunit 1 "GO:0005654,GO:0016020,GO:0016021,GO:0016180,GO:0031965,GO:0032039,GO:0034474,GO:0042795" nucleoplasm|membrane|integral component of membrane|snRNA processing|nuclear membrane|integrator complex|U2 snRNA 3'-end processing|snRNA transcription by RNA polymerase II INTS10 598.4146615 658.5819877 538.2473354 0.817282199 -0.291093782 0.268964919 1 11.18984727 8.992229393 55174 integrator complex subunit 10 "GO:0005515,GO:0005634,GO:0005654,GO:0016180,GO:0032039,GO:0042795" protein binding|nucleus|nucleoplasm|snRNA processing|integrator complex|snRNA transcription by RNA polymerase II INTS11 1394.163204 1375.427153 1412.899255 1.027243975 0.038778868 0.874290048 1 28.34132016 28.62627621 54973 integrator complex subunit 11 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016180,GO:0016787,GO:0032039,GO:0042795,GO:0072562" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|snRNA processing|hydrolase activity|integrator complex|snRNA transcription by RNA polymerase II|blood microparticle INTS12 399.3578422 403.6805865 395.0350979 0.978583343 -0.031233368 0.923085397 1 8.366481929 8.050296482 57117 integrator complex subunit 12 "GO:0005515,GO:0005634,GO:0005654,GO:0016180,GO:0032039,GO:0034472,GO:0042795,GO:0046872" protein binding|nucleus|nucleoplasm|snRNA processing|integrator complex|snRNA 3'-end processing|snRNA transcription by RNA polymerase II|metal ion binding INTS13 841.1644479 912.4429751 769.8859208 0.843763327 -0.24508971 0.327769871 1 17.55421939 14.56375438 55726 integrator complex subunit 13 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007052,GO:0007346,GO:0016604,GO:0030317,GO:0032039,GO:0042795,GO:0043231,GO:0051301,GO:0051642,GO:0080154,GO:0090435" protein binding|nucleus|nucleoplasm|cytoplasm|mitotic spindle organization|regulation of mitotic cell cycle|nuclear body|flagellated sperm motility|integrator complex|snRNA transcription by RNA polymerase II|intracellular membrane-bounded organelle|cell division|centrosome localization|regulation of fertilization|protein localization to nuclear envelope INTS14 730.7711359 764.7042037 696.8380681 0.911251782 -0.134078365 0.601322976 1 15.23930466 13.65446601 81556 integrator complex subunit 14 "GO:0005654,GO:0032039,GO:0034472,GO:0042795" nucleoplasm|integrator complex|snRNA 3'-end processing|snRNA transcription by RNA polymerase II INTS2 770.7333356 779.2699981 762.1966731 0.978090617 -0.031959963 0.904607168 1 6.401140151 6.156127518 57508 integrator complex subunit 2 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0016020,GO:0016021,GO:0016180,GO:0031965,GO:0032039,GO:0034472,GO:0042795" protein binding|nucleus|nucleoplasm|cytoplasm|membrane|integral component of membrane|snRNA processing|nuclear membrane|integrator complex|snRNA 3'-end processing|snRNA transcription by RNA polymerase II INTS3 1693.333114 1747.895323 1638.770905 0.937568105 -0.093004604 0.696937866 1 18.99449417 17.51062856 65123 integrator complex subunit 3 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006281,GO:0006974,GO:0010212,GO:0016180,GO:0032039,GO:0035861,GO:0042795,GO:0044818,GO:0070876" protein binding|nucleus|nucleoplasm|cytoplasm|DNA repair|cellular response to DNA damage stimulus|response to ionizing radiation|snRNA processing|integrator complex|site of double-strand break|snRNA transcription by RNA polymerase II|mitotic G2/M transition checkpoint|SOSS complex INTS4 793.9495336 808.4015868 779.4974803 0.964245361 -0.052527794 0.839362474 1 11.7331811 11.12434658 92105 integrator complex subunit 4 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0016180,GO:0032039,GO:0042795" protein binding|nucleus|nucleoplasm|nucleolus|snRNA processing|integrator complex|snRNA transcription by RNA polymerase II INTS5 426.9187492 483.7924554 370.0450431 0.764883865 -0.38668738 0.173584553 1 7.859699901 5.911159013 80789 integrator complex subunit 5 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016020,GO:0016021,GO:0016180,GO:0031965,GO:0032039,GO:0034472,GO:0042795" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|membrane|integral component of membrane|snRNA processing|nuclear membrane|integrator complex|snRNA 3'-end processing|snRNA transcription by RNA polymerase II INTS6 1615.846817 1631.368968 1600.324667 0.980970399 -0.027718492 0.909863205 1 3.720489017 3.588616981 26512 integrator complex subunit 6 "GO:0004888,GO:0005515,GO:0005634,GO:0005654,GO:0015629,GO:0016180,GO:0032039,GO:0034472,GO:0042795" transmembrane signaling receptor activity|protein binding|nucleus|nucleoplasm|actin cytoskeleton|snRNA processing|integrator complex|snRNA 3'-end processing|snRNA transcription by RNA polymerase II INTS6L 418.4224455 399.5189309 437.32596 1.094631383 0.130445124 0.653357751 1 3.455687368 3.719405417 203522 integrator complex subunit 6 like "GO:0032039,GO:0034472" integrator complex|snRNA 3'-end processing INTS7 570.3580852 615.9250185 524.791152 0.852037401 -0.231011335 0.385782815 1 6.199695627 5.193979198 25896 integrator complex subunit 7 "GO:0000077,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0016180,GO:0016604,GO:0032039,GO:0034472,GO:0042795,GO:0071479" DNA damage checkpoint|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|snRNA processing|nuclear body|integrator complex|snRNA 3'-end processing|snRNA transcription by RNA polymerase II|cellular response to ionizing radiation INTS8 2442.496389 2288.910542 2596.082237 1.134199957 0.181675006 0.44250734 1 14.54398723 16.21975499 55656 integrator complex subunit 8 "GO:0005515,GO:0005654,GO:0016180,GO:0032039,GO:0034472,GO:0042795" protein binding|nucleoplasm|snRNA processing|integrator complex|snRNA 3'-end processing|snRNA transcription by RNA polymerase II INTS9 314.6773528 350.6194785 278.7352272 0.794979299 -0.331010801 0.286659089 1 5.934639123 4.638967328 55756 integrator complex subunit 9 "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0016180,GO:0032039,GO:0042795" protein binding|nucleus|nucleoplasm|cytosol|snRNA processing|integrator complex|snRNA transcription by RNA polymerase II INTU 134.1894675 129.0113214 139.3676136 1.08027429 0.11139767 0.807485982 1 1.313198 1.394875452 27152 inturned planar cell polarity protein "GO:0001736,GO:0005515,GO:0005737,GO:0007399,GO:0008589,GO:0009986,GO:0010839,GO:0016192,GO:0021513,GO:0021915,GO:0030216,GO:0030278,GO:0031069,GO:0031514,GO:0036064,GO:0042733,GO:0043587,GO:0044458,GO:0045880,GO:0051782,GO:0060021,GO:0060173,GO:0060271,GO:1905515" establishment of planar polarity|protein binding|cytoplasm|nervous system development|regulation of smoothened signaling pathway|cell surface|negative regulation of keratinocyte proliferation|vesicle-mediated transport|spinal cord dorsal/ventral patterning|neural tube development|keratinocyte differentiation|regulation of ossification|hair follicle morphogenesis|motile cilium|ciliary basal body|embryonic digit morphogenesis|tongue morphogenesis|motile cilium assembly|positive regulation of smoothened signaling pathway|negative regulation of cell division|roof of mouth development|limb development|cilium assembly|non-motile cilium assembly INVS 576.0948385 690.8348181 461.3548589 0.667822245 -0.582463946 0.02795224 0.877967194 7.379620604 4.845806792 27130 inversin "GO:0005515,GO:0005516,GO:0005634,GO:0005737,GO:0005819,GO:0005874,GO:0005929,GO:0007275,GO:0016020,GO:0016055,GO:0090090,GO:0097543,GO:1904108" protein binding|calmodulin binding|nucleus|cytoplasm|spindle|microtubule|cilium|multicellular organism development|membrane|Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|ciliary inversin compartment|protein localization to ciliary inversin compartment hsa04310 Wnt signaling pathway IP6K1 944.6617059 980.0698774 909.2535344 0.927743578 -0.108201986 0.664163807 1 10.36143583 9.451899099 9807 inositol hexakisphosphate kinase 1 "GO:0000827,GO:0000828,GO:0000832,GO:0001650,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016301,GO:0032958,GO:0043647,GO:0046854,GO:0052723,GO:0052724,GO:0120163" "inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity|fibrillar center|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|kinase activity|inositol phosphate biosynthetic process|inositol phosphate metabolic process|phosphatidylinositol phosphorylation|inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|negative regulation of cold-induced thermogenesis" hsa04070 Phosphatidylinositol signaling system IP6K2 1375.727634 1408.720397 1342.734871 0.953159245 -0.069210828 0.775230594 1 14.40521527 13.50070339 51447 inositol hexakisphosphate kinase 2 "GO:0000828,GO:0000832,GO:0001650,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006817,GO:0016301,GO:0030054,GO:0030308,GO:0032958,GO:0043065,GO:0043647,GO:0046854,GO:0060337,GO:0097243,GO:1905396" inositol hexakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity|fibrillar center|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|phosphate ion transport|kinase activity|cell junction|negative regulation of cell growth|inositol phosphate biosynthetic process|positive regulation of apoptotic process|inositol phosphate metabolic process|phosphatidylinositol phosphorylation|type I interferon signaling pathway|flavonoid binding|cellular response to flavonoid hsa04070 Phosphatidylinositol signaling system IPMK 596.4231525 631.5312268 561.3150783 0.888816031 -0.170043257 0.520927894 1 5.268666698 4.604513844 253430 inositol polyphosphate multikinase "GO:0000823,GO:0000824,GO:0000825,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0008440,GO:0016301,GO:0032957,GO:0032958,GO:0043647,GO:0046854,GO:0046872,GO:0046934,GO:0047326,GO:0051765,GO:0052812,GO:0070266,GO:0097243,GO:0102732" "inositol-1,4,5-trisphosphate 6-kinase activity|inositol tetrakisphosphate 3-kinase activity|inositol tetrakisphosphate 6-kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|inositol-1,4,5-trisphosphate 3-kinase activity|kinase activity|inositol trisphosphate metabolic process|inositol phosphate biosynthetic process|inositol phosphate metabolic process|phosphatidylinositol phosphorylation|metal ion binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|inositol tetrakisphosphate 5-kinase activity|inositol tetrakisphosphate kinase activity|phosphatidylinositol-3,4-bisphosphate 5-kinase activity|necroptotic process|flavonoid binding|myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system IPO11 819.2566201 816.7248979 821.7883424 1.006199694 0.008916656 0.977121895 1 9.456955245 9.356355038 51194 importin 11 "GO:0005515,GO:0005635,GO:0005654,GO:0005829,GO:0006606,GO:0006610,GO:0061608" protein binding|nuclear envelope|nucleoplasm|cytosol|protein import into nucleus|ribosomal protein import into nucleus|nuclear import signal receptor activity IPO13 584.8597129 605.5208797 564.1985462 0.931757376 -0.10197376 0.704136096 1 7.609026713 6.971129121 9670 importin 13 "GO:0005515,GO:0005634,GO:0005737,GO:0006606" protein binding|nucleus|cytoplasm|protein import into nucleus IPO4 691.3285288 852.0989699 530.5580877 0.622648432 -0.683510295 0.007819331 0.544463388 13.00027328 7.959147611 79711 importin 4 "GO:0000785,GO:0005515,GO:0005634,GO:0005737,GO:0006335,GO:0006336,GO:0006606,GO:0008139,GO:0016020,GO:0032991,GO:0061608" chromatin|protein binding|nucleus|cytoplasm|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|protein import into nucleus|nuclear localization sequence binding|membrane|protein-containing complex|nuclear import signal receptor activity IPO5 11768.44433 12000.13372 11536.75494 0.961385532 -0.056813003 0.824139718 1 103.0450654 97.40829906 3843 importin 5 "GO:0003723,GO:0005095,GO:0005515,GO:0005634,GO:0005643,GO:0005730,GO:0005737,GO:0006606,GO:0006607,GO:0006610,GO:0008139,GO:0016020,GO:0016032,GO:0031267,GO:0034260,GO:0042307,GO:0045736,GO:0061608,GO:0071230" RNA binding|GTPase inhibitor activity|protein binding|nucleus|nuclear pore|nucleolus|cytoplasm|protein import into nucleus|NLS-bearing protein import into nucleus|ribosomal protein import into nucleus|nuclear localization sequence binding|membrane|viral process|small GTPase binding|negative regulation of GTPase activity|positive regulation of protein import into nucleus|negative regulation of cyclin-dependent protein serine/threonine kinase activity|nuclear import signal receptor activity|cellular response to amino acid stimulus IPO7 14195.05895 13947.78851 14442.32939 1.03545658 0.050267059 0.847344286 1 120.799714 122.9897666 10527 importin 7 "GO:0005215,GO:0005515,GO:0005635,GO:0005643,GO:0005654,GO:0005829,GO:0006606,GO:0007165,GO:0016020,GO:0016032,GO:0030695,GO:0031267,GO:0042393,GO:0045087,GO:0045736,GO:0046332" transporter activity|protein binding|nuclear envelope|nuclear pore|nucleoplasm|cytosol|protein import into nucleus|signal transduction|membrane|viral process|GTPase regulator activity|small GTPase binding|histone binding|innate immune response|negative regulation of cyclin-dependent protein serine/threonine kinase activity|SMAD binding IPO8 1814.0318 1863.381264 1764.682335 0.947032349 -0.078514388 0.74213461 1 16.35074536 15.22556956 10526 importin 8 "GO:0005515,GO:0005635,GO:0005654,GO:0005829,GO:0006606,GO:0007165,GO:0031267,GO:0060964" protein binding|nuclear envelope|nucleoplasm|cytosol|protein import into nucleus|signal transduction|small GTPase binding|regulation of gene silencing by miRNA IPO9 4016.268154 4279.222299 3753.314008 0.8771019 -0.189183633 0.427140802 1 20.00475028 17.25259251 55705 importin 9 "GO:0005515,GO:0005635,GO:0005737,GO:0005829,GO:0006606,GO:0016020,GO:0042393,GO:0061608" protein binding|nuclear envelope|cytoplasm|cytosol|protein import into nucleus|membrane|histone binding|nuclear import signal receptor activity IPP 393.2638139 420.3272086 366.2004192 0.871227015 -0.198879405 0.496974977 1 5.193815836 4.449273042 3652 intracisternal A particle-promoted polypeptide "GO:0003779,GO:0005737,GO:0015629" actin binding|cytoplasm|actin cytoskeleton IPPK 468.5113812 427.6101058 509.4126567 1.191301725 0.252538856 0.364589623 1 5.103033415 5.977524452 64768 inositol-pentakisphosphate 2-kinase "GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0032958,GO:0035299,GO:0043647,GO:0052746,GO:0060090,GO:1901838" protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytosol|inositol phosphate biosynthetic process|inositol pentakisphosphate 2-kinase activity|inositol phosphate metabolic process|inositol phosphorylation|molecular adaptor activity|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system IQANK1 15.89367182 13.52538047 18.26196316 1.350199589 0.433172685 0.689082402 1 0.151611993 0.201280965 642574 IQ motif and ankyrin repeat containing 1 "GO:0005634,GO:0005737,GO:2000812" nucleus|cytoplasm|regulation of barbed-end actin filament capping IQCB1 411.4068902 417.2059669 405.6078134 0.972200413 -0.040674348 0.895825277 1 7.776987658 7.434271022 9657 IQ motif containing B1 "GO:0001750,GO:0005515,GO:0005516,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0005929,GO:0015630,GO:0019899,GO:0032391,GO:0045171,GO:0045494,GO:0048496,GO:0060271,GO:0070062,GO:0072686,GO:0097711" photoreceptor outer segment|protein binding|calmodulin binding|nucleoplasm|centrosome|centriole|cytosol|cilium|microtubule cytoskeleton|enzyme binding|photoreceptor connecting cilium|intercellular bridge|photoreceptor cell maintenance|maintenance of animal organ identity|cilium assembly|extracellular exosome|mitotic spindle|ciliary basal body-plasma membrane docking IQCC 90.66507719 109.2434577 72.0866967 0.65987198 -0.599741937 0.216405284 1 2.897675226 1.880098373 55721 IQ motif containing C GO:0005515 protein binding IQCD 154.462447 207.0423626 101.8825313 0.492085436 -1.023019276 0.01101861 0.623624625 3.653925386 1.767955645 115811 IQ motif containing D "GO:0005737,GO:0031514,GO:0036064" cytoplasm|motile cilium|ciliary basal body IQCE 432.205107 483.7924554 380.6177586 0.786737689 -0.346045396 0.222120203 1 3.34184755 2.585162031 23288 IQ motif containing E "GO:0005515,GO:0005929,GO:0035108,GO:0060170" protein binding|cilium|limb morphogenesis|ciliary membrane IQCG 103.3186205 113.4051132 93.23212773 0.822115733 -0.282586593 0.550809332 1 1.981087549 1.601429433 84223 IQ motif containing G "GO:0002177,GO:0005516,GO:0005737,GO:0005829,GO:0007286,GO:0007288,GO:0030544,GO:0031514,GO:0036126,GO:0044782,GO:0070062" manchette|calmodulin binding|cytoplasm|cytosol|spermatid development|sperm axoneme assembly|Hsp70 protein binding|motile cilium|sperm flagellum|cilium organization|extracellular exosome IQCH 54.84502575 52.02069413 57.66935736 1.108584926 0.148719296 0.825857589 1 0.492592057 0.536942218 64799 IQ motif containing H "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process IQCK 123.4035159 161.2641518 85.54288008 0.530451927 -0.914706084 0.035515495 0.951348545 2.688650856 1.402334502 124152 IQ motif containing K IQGAP1 12028.13458 12850.15186 11206.11729 0.872061078 -0.197498911 0.440328303 1 95.18237161 81.615868 8826 IQ motif containing GTPase activating protein 1 "GO:0001726,GO:0005078,GO:0005095,GO:0005096,GO:0005509,GO:0005515,GO:0005516,GO:0005547,GO:0005634,GO:0005737,GO:0005829,GO:0005874,GO:0005884,GO:0005886,GO:0005925,GO:0007165,GO:0007173,GO:0007346,GO:0015629,GO:0015630,GO:0016032,GO:0016477,GO:0019901,GO:0019903,GO:0019904,GO:0030424,GO:0030426,GO:0030496,GO:0030667,GO:0031234,GO:0031267,GO:0032956,GO:0032991,GO:0034260,GO:0036057,GO:0036464,GO:0043005,GO:0043312,GO:0043406,GO:0043410,GO:0043539,GO:0043547,GO:0044548,GO:0045121,GO:0045296,GO:0045860,GO:0051015,GO:0051019,GO:0051894,GO:0060090,GO:0070062,GO:0071277,GO:0071364,GO:0072015,GO:1900006,GO:1900086,GO:1903829,GO:1904754,GO:1990138,GO:1990776" "ruffle|MAP-kinase scaffold activity|GTPase inhibitor activity|GTPase activator activity|calcium ion binding|protein binding|calmodulin binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|cytoplasm|cytosol|microtubule|actin filament|plasma membrane|focal adhesion|signal transduction|epidermal growth factor receptor signaling pathway|regulation of mitotic cell cycle|actin cytoskeleton|microtubule cytoskeleton|viral process|cell migration|protein kinase binding|protein phosphatase binding|protein domain specific binding|axon|growth cone|midbody|secretory granule membrane|extrinsic component of cytoplasmic side of plasma membrane|small GTPase binding|regulation of actin cytoskeleton organization|protein-containing complex|negative regulation of GTPase activity|slit diaphragm|cytoplasmic ribonucleoprotein granule|neuron projection|neutrophil degranulation|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|protein serine/threonine kinase activator activity|positive regulation of GTPase activity|S100 protein binding|membrane raft|cadherin binding|positive regulation of protein kinase activity|actin filament binding|mitogen-activated protein kinase binding|positive regulation of focal adhesion assembly|molecular adaptor activity|extracellular exosome|cellular response to calcium ion|cellular response to epidermal growth factor stimulus|glomerular visceral epithelial cell development|positive regulation of dendrite development|positive regulation of peptidyl-tyrosine autophosphorylation|positive regulation of cellular protein localization|positive regulation of vascular associated smooth muscle cell migration|neuron projection extension|response to angiotensin" "hsa04520,hsa04810,hsa05205" Adherens junction|Regulation of actin cytoskeleton|Proteoglycans in cancer IQGAP2 5.643018428 9.363724944 1.922311912 0.205293505 -2.284240111 0.166157707 1 0.076457281 0.015433529 10788 IQ motif containing GTPase activating protein 2 "GO:0003779,GO:0005095,GO:0005096,GO:0005516,GO:0005547,GO:0005737,GO:0005829,GO:0005886,GO:0005902,GO:0007165,GO:0009986,GO:0015629,GO:0030027,GO:0030175,GO:0030667,GO:0031267,GO:0032956,GO:0034260,GO:0034314,GO:0043312,GO:0043547,GO:0051015,GO:0070062,GO:0070493,GO:0071933,GO:2000249" "actin binding|GTPase inhibitor activity|GTPase activator activity|calmodulin binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|cytosol|plasma membrane|microvillus|signal transduction|cell surface|actin cytoskeleton|lamellipodium|filopodium|secretory granule membrane|small GTPase binding|regulation of actin cytoskeleton organization|negative regulation of GTPase activity|Arp2/3 complex-mediated actin nucleation|neutrophil degranulation|positive regulation of GTPase activity|actin filament binding|extracellular exosome|thrombin-activated receptor signaling pathway|Arp2/3 complex binding|regulation of actin cytoskeleton reorganization" hsa04810 Regulation of actin cytoskeleton IQGAP3 3706.404798 4206.393328 3206.416269 0.762272099 -0.391622025 0.099549184 1 33.92586986 25.42799949 128239 IQ motif containing GTPase activating protein 3 "GO:0000082,GO:0000187,GO:0005096,GO:0005515,GO:0005516,GO:0005737,GO:0005829,GO:0005911,GO:0007265,GO:0008361,GO:0010628,GO:0010629,GO:0016328,GO:0032956,GO:0033601,GO:0043547,GO:0051015,GO:0070371,GO:0070856,GO:0071310" G1/S transition of mitotic cell cycle|activation of MAPK activity|GTPase activator activity|protein binding|calmodulin binding|cytoplasm|cytosol|cell-cell junction|Ras protein signal transduction|regulation of cell size|positive regulation of gene expression|negative regulation of gene expression|lateral plasma membrane|regulation of actin cytoskeleton organization|positive regulation of mammary gland epithelial cell proliferation|positive regulation of GTPase activity|actin filament binding|ERK1 and ERK2 cascade|myosin VI light chain binding|cellular response to organic substance hsa04810 Regulation of actin cytoskeleton IQSEC1 808.8719886 846.8969005 770.8470767 0.910201792 -0.135741668 0.59157381 1 4.393208694 3.931793491 9922 IQ motif and Sec7 domain ArfGEF 1 "GO:0005085,GO:0005515,GO:0005730,GO:0008021,GO:0008289,GO:0014069,GO:0016020,GO:0030036,GO:0032012,GO:0043231,GO:0043547,GO:0051549,GO:0060996,GO:0120183" guanyl-nucleotide exchange factor activity|protein binding|nucleolus|synaptic vesicle|lipid binding|postsynaptic density|membrane|actin cytoskeleton organization|regulation of ARF protein signal transduction|intracellular membrane-bounded organelle|positive regulation of GTPase activity|positive regulation of keratinocyte migration|dendritic spine development|positive regulation of focal adhesion disassembly hsa04144 Endocytosis IQSEC2 344.1857239 368.3065145 320.0649333 0.869017845 -0.202542293 0.505959638 1 1.371656787 1.172047816 23096 IQ motif and Sec7 domain ArfGEF 2 "GO:0005085,GO:0005737,GO:0030036,GO:0032012,GO:0050790,GO:0050804,GO:0098685,GO:0098696" guanyl-nucleotide exchange factor activity|cytoplasm|actin cytoskeleton organization|regulation of ARF protein signal transduction|regulation of catalytic activity|modulation of chemical synaptic transmission|Schaffer collateral - CA1 synapse|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane hsa04144 Endocytosis IQUB 18.89602658 16.64662212 21.14543103 1.270253561 0.345116509 0.7379224 1 0.10950322 0.136769258 154865 IQ motif and ubiquitin domain containing "GO:0001669,GO:0005515,GO:0007224,GO:0031514,GO:0060271" acrosomal vesicle|protein binding|smoothened signaling pathway|motile cilium|cilium assembly IRAK1 6737.503457 5962.611961 7512.394952 1.259916795 0.333328461 0.171781333 1 88.86167036 110.0848402 3654 interleukin 1 receptor associated kinase 1 "GO:0000187,GO:0001959,GO:0002224,GO:0002755,GO:0004672,GO:0004674,GO:0004704,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005811,GO:0005829,GO:0005886,GO:0006468,GO:0007250,GO:0007254,GO:0007568,GO:0010008,GO:0016032,GO:0016301,GO:0019221,GO:0031072,GO:0031663,GO:0032088,GO:0032481,GO:0032496,GO:0032991,GO:0034134,GO:0034142,GO:0034162,GO:0034605,GO:0035556,GO:0042802,GO:0042803,GO:0043066,GO:0043123,GO:0043406,GO:0045087,GO:0046777,GO:0046982,GO:0048661,GO:0051092,GO:0060337,GO:0070423,GO:0070498,GO:0070555,GO:0071222,GO:0071456,GO:0106310,GO:0106311,GO:1901224,GO:1904996" activation of MAPK activity|regulation of cytokine-mediated signaling pathway|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|NF-kappaB-inducing kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|lipid droplet|cytosol|plasma membrane|protein phosphorylation|activation of NF-kappaB-inducing kinase activity|JNK cascade|aging|endosome membrane|viral process|kinase activity|cytokine-mediated signaling pathway|heat shock protein binding|lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of type I interferon production|response to lipopolysaccharide|protein-containing complex|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 9 signaling pathway|cellular response to heat|intracellular signal transduction|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAP kinase activity|innate immune response|protein autophosphorylation|protein heterodimerization activity|positive regulation of smooth muscle cell proliferation|positive regulation of NF-kappaB transcription factor activity|type I interferon signaling pathway|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|response to interleukin-1|cellular response to lipopolysaccharide|cellular response to hypoxia|protein serine kinase activity|protein threonine kinase activity|positive regulation of NIK/NF-kappaB signaling|positive regulation of leukocyte adhesion to vascular endothelial cell "hsa04010,hsa04064,hsa04620,hsa04722,hsa05130,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05145,hsa05152,hsa05161,hsa05162,hsa05168,hsa05169,hsa05170,hsa05171" MAPK signaling pathway|NF-kappa B signaling pathway|Toll-like receptor signaling pathway|Neurotrophin signaling pathway|Pathogenic Escherichia coli infection|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis B|Measles|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19 IRAK1BP1 139.2726501 136.2942186 142.2510815 1.04370591 0.061715254 0.899817824 1 1.249788995 1.282584589 134728 interleukin 1 receptor associated kinase 1 binding protein 1 "GO:0005515,GO:0005634,GO:0005737,GO:0006955,GO:0007249" protein binding|nucleus|cytoplasm|immune response|I-kappaB kinase/NF-kappaB signaling IRAK2 1830.587874 2121.403907 1539.771842 0.725826815 -0.462302738 0.05119456 1 32.99779293 23.54990071 3656 interleukin 1 receptor associated kinase 2 "GO:0000187,GO:0001959,GO:0002224,GO:0002755,GO:0004672,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0006954,GO:0007249,GO:0007254,GO:0010008,GO:0019221,GO:0031663,GO:0032088,GO:0034162,GO:0035556,GO:0042803,GO:0046982,GO:0051092,GO:0070423,GO:0070498,GO:0070555" activation of MAPK activity|regulation of cytokine-mediated signaling pathway|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|protein kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|protein phosphorylation|inflammatory response|I-kappaB kinase/NF-kappaB signaling|JNK cascade|endosome membrane|cytokine-mediated signaling pathway|lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|toll-like receptor 9 signaling pathway|intracellular signal transduction|protein homodimerization activity|protein heterodimerization activity|positive regulation of NF-kappaB transcription factor activity|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|response to interleukin-1 "hsa04722,hsa05152" Neurotrophin signaling pathway|Tuberculosis IRAK3 1578.032799 1950.77603 1205.289569 0.617851332 -0.694668357 0.003615136 0.380284526 12.50112048 7.59458604 11213 interleukin 1 receptor associated kinase 3 "GO:0000287,GO:0001960,GO:0002755,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005886,GO:0006468,GO:0009615,GO:0010933,GO:0010936,GO:0019221,GO:0032088,GO:0032494,GO:0032496,GO:0032695,GO:0032715,GO:0032720,GO:0034122,GO:0035556,GO:0042177,GO:0042803,GO:0043242,GO:0043244,GO:0043330,GO:0043407,GO:0045824,GO:0046777,GO:0046982,GO:0051092,GO:0070498,GO:0070555,GO:0106310,GO:0106311" magnesium ion binding|negative regulation of cytokine-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|plasma membrane|protein phosphorylation|response to virus|positive regulation of macrophage tolerance induction|negative regulation of macrophage cytokine production|cytokine-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|response to peptidoglycan|response to lipopolysaccharide|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|negative regulation of toll-like receptor signaling pathway|intracellular signal transduction|negative regulation of protein catabolic process|protein homodimerization activity|negative regulation of protein-containing complex disassembly|regulation of protein-containing complex disassembly|response to exogenous dsRNA|negative regulation of MAP kinase activity|negative regulation of innate immune response|protein autophosphorylation|protein heterodimerization activity|positive regulation of NF-kappaB transcription factor activity|interleukin-1-mediated signaling pathway|response to interleukin-1|protein serine kinase activity|protein threonine kinase activity hsa04722 Neurotrophin signaling pathway IRAK4 539.3142455 532.6919079 545.936583 1.024863669 0.03543201 0.902141233 1 4.653591108 4.689488738 51135 interleukin 1 receptor associated kinase 4 "GO:0000287,GO:0002224,GO:0002446,GO:0002755,GO:0004672,GO:0004674,GO:0005149,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0007254,GO:0010008,GO:0019221,GO:0034162,GO:0035556,GO:0043123,GO:0045087,GO:0048661,GO:0070498,GO:0106310,GO:0106311,GO:1990266" magnesium ion binding|toll-like receptor signaling pathway|neutrophil mediated immunity|MyD88-dependent toll-like receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|interleukin-1 receptor binding|protein binding|ATP binding|extracellular space|nucleus|cytoplasm|cytosol|plasma membrane|protein phosphorylation|JNK cascade|endosome membrane|cytokine-mediated signaling pathway|toll-like receptor 9 signaling pathway|intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of smooth muscle cell proliferation|interleukin-1-mediated signaling pathway|protein serine kinase activity|protein threonine kinase activity|neutrophil migration "hsa04010,hsa04064,hsa04620,hsa04621,hsa04722,hsa05130,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05145,hsa05152,hsa05161,hsa05162,hsa05164,hsa05168,hsa05169,hsa05170,hsa05171" MAPK signaling pathway|NF-kappa B signaling pathway|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Neurotrophin signaling pathway|Pathogenic Escherichia coli infection|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis B|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19 IREB2 1198.430187 1220.405484 1176.45489 0.963986892 -0.052914565 0.830075179 1 9.237100793 8.755440274 3658 iron responsive element binding protein 2 "GO:0003723,GO:0003994,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0006099,GO:0006101,GO:0006782,GO:0006826,GO:0006879,GO:0009791,GO:0017148,GO:0030316,GO:0030350,GO:0030371,GO:0034101,GO:0046872,GO:0050892,GO:0051539,GO:0055072" "RNA binding|aconitate hydratase activity|protein binding|cytoplasm|mitochondrion|cytosol|tricarboxylic acid cycle|citrate metabolic process|protoporphyrinogen IX biosynthetic process|iron ion transport|cellular iron ion homeostasis|post-embryonic development|negative regulation of translation|osteoclast differentiation|iron-responsive element binding|translation repressor activity|erythrocyte homeostasis|metal ion binding|intestinal absorption|4 iron, 4 sulfur cluster binding|iron ion homeostasis" IRF1 581.1037935 683.5519209 478.6556661 0.700247708 -0.514062738 0.051910747 1 10.2184621 7.035717825 3659 interferon regulatory factor 1 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0002376,GO:0002819,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006915,GO:0007050,GO:0007596,GO:0008285,GO:0032481,GO:0032728,GO:0032735,GO:0034124,GO:0035458,GO:0043374,GO:0045088,GO:0045590,GO:0045892,GO:0045893,GO:0045944,GO:0051607,GO:0051726,GO:0060333,GO:0060337,GO:0071260,GO:2000564" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|immune system process|regulation of adaptive immune response|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|apoptotic process|cell cycle arrest|blood coagulation|negative regulation of cell population proliferation|positive regulation of type I interferon production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|regulation of MyD88-dependent toll-like receptor signaling pathway|cellular response to interferon-beta|CD8-positive, alpha-beta T cell differentiation|regulation of innate immune response|negative regulation of regulatory T cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|defense response to virus|regulation of cell cycle|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|cellular response to mechanical stimulus|regulation of CD8-positive, alpha-beta T cell proliferation" "hsa04625,hsa04668,hsa04917,hsa05133,hsa05165" C-type lectin receptor signaling pathway|TNF signaling pathway|Prolactin signaling pathway|Pertussis|Human papillomavirus infection IRF IRF2 656.3664521 653.3799183 659.3529858 1.009141798 0.013128907 0.9660775 1 3.976018857 3.945225295 3660 interferon regulatory factor 2 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0002376,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005925,GO:0006355,GO:0006357,GO:0007596,GO:0008283,GO:0045944,GO:0051607,GO:0060333,GO:0060337,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|immune system process|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|focal adhesion|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|blood coagulation|cell population proliferation|positive regulation of transcription by RNA polymerase II|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|sequence-specific double-stranded DNA binding" IRF IRF2BP1 215.1687577 223.6889848 206.6485305 0.923820772 -0.11431511 0.756883554 1 4.711077346 4.279363085 26145 interferon regulatory factor 2 binding protein 1 "GO:0000122,GO:0000209,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008134,GO:0046872,GO:0061630" negative regulation of transcription by RNA polymerase II|protein polyubiquitination|transcription corepressor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription factor binding|metal ion binding|ubiquitin protein ligase activity IRF2BP2 1807.849067 1801.996845 1813.701289 1.006495263 0.009340383 0.97116495 1 18.09053041 17.9033464 359948 interferon regulatory factor 2 binding protein 2 "GO:0000122,GO:0002327,GO:0003714,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0046872" negative regulation of transcription by RNA polymerase II|immature B cell differentiation|transcription corepressor activity|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|metal ion binding IRF2BPL 2268.379321 2158.858806 2377.899835 1.101461489 0.139419054 0.556040248 1 27.65586334 29.9521303 64207 interferon regulatory factor 2 binding protein like "GO:0000122,GO:0003714,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0006357,GO:0007399,GO:0016567,GO:0045944,GO:0046543,GO:0046872,GO:0061630" negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|extracellular space|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|nervous system development|protein ubiquitination|positive regulation of transcription by RNA polymerase II|development of secondary female sexual characteristics|metal ion binding|ubiquitin protein ligase activity IRF3 1162.144649 1125.727821 1198.561477 1.06469917 0.090445856 0.711919746 1 33.33963641 34.9026943 3661 interferon regulatory factor 3 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0002376,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006357,GO:0006915,GO:0006974,GO:0016032,GO:0019904,GO:0031663,GO:0032479,GO:0032480,GO:0032481,GO:0032727,GO:0032728,GO:0035666,GO:0039530,GO:0042802,GO:0042803,GO:0042981,GO:0043123,GO:0043565,GO:0045944,GO:0050727,GO:0051607,GO:0060333,GO:0060337,GO:0060340,GO:0071360,GO:0071888,GO:0097300,GO:0098586,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|immune system process|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|regulation of transcription by RNA polymerase II|apoptotic process|cellular response to DNA damage stimulus|viral process|protein domain specific binding|lipopolysaccharide-mediated signaling pathway|regulation of type I interferon production|negative regulation of type I interferon production|positive regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|TRIF-dependent toll-like receptor signaling pathway|MDA-5 signaling pathway|identical protein binding|protein homodimerization activity|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|regulation of inflammatory response|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|positive regulation of type I interferon-mediated signaling pathway|cellular response to exogenous dsRNA|macrophage apoptotic process|programmed necrotic cell death|cellular response to virus|sequence-specific double-stranded DNA binding" "hsa04620,hsa04621,hsa04622,hsa04623,hsa05131,hsa05133,hsa05135,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05203" Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Shigellosis|Pertussis|Yersinia infection|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Viral carcinogenesis IRF IRF5 119.5840442 98.83931885 140.3287696 1.41976666 0.505653841 0.252005175 1 1.315757742 1.83680937 3663 interferon regulatory factor 5 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0002376,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006357,GO:0006954,GO:0019221,GO:0019901,GO:0032481,GO:0032494,GO:0032495,GO:0032727,GO:0032728,GO:0032735,GO:0042802,GO:0043065,GO:0043565,GO:0045087,GO:0045944,GO:0051607,GO:0060333,GO:0060337,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|immune system process|protein binding|nucleus|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|inflammatory response|cytokine-mediated signaling pathway|protein kinase binding|positive regulation of type I interferon production|response to peptidoglycan|response to muramyl dipeptide|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|identical protein binding|positive regulation of apoptotic process|sequence-specific DNA binding|innate immune response|positive regulation of transcription by RNA polymerase II|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|sequence-specific double-stranded DNA binding" hsa04620 Toll-like receptor signaling pathway IRF IRF6 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.049598014 0.022526473 3664 interferon regulatory factor 6 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0002376,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0007050,GO:0008285,GO:0030054,GO:0030216,GO:0043565,GO:0043616,GO:0045893,GO:0045944,GO:0048468,GO:0060021,GO:0060173,GO:0060333,GO:0060337,GO:0060644,GO:0070062,GO:1904888,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|immune system process|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|cell cycle arrest|negative regulation of cell population proliferation|cell junction|keratinocyte differentiation|sequence-specific DNA binding|keratinocyte proliferation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cell development|roof of mouth development|limb development|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|mammary gland epithelial cell differentiation|extracellular exosome|cranial skeletal system development|sequence-specific double-stranded DNA binding" IRF7 236.7947667 223.6889848 249.9005486 1.117178608 0.159859854 0.647491923 1 6.081441668 6.6803672 3665 interferon regulatory factor 7 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0002376,GO:0002819,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006974,GO:0009615,GO:0010008,GO:0016064,GO:0019043,GO:0032479,GO:0032481,GO:0032607,GO:0032608,GO:0032727,GO:0032728,GO:0034124,GO:0034127,GO:0035666,GO:0039530,GO:0045087,GO:0045655,GO:0045893,GO:0045944,GO:0050776,GO:0051607,GO:0060333,GO:0060337,GO:0060340,GO:1990837,GO:2000110" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|immune system process|regulation of adaptive immune response|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|response to virus|endosome membrane|immunoglobulin mediated immune response|establishment of viral latency|regulation of type I interferon production|positive regulation of type I interferon production|interferon-alpha production|interferon-beta production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of MyD88-dependent toll-like receptor signaling pathway|regulation of MyD88-independent toll-like receptor signaling pathway|TRIF-dependent toll-like receptor signaling pathway|MDA-5 signaling pathway|innate immune response|regulation of monocyte differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of immune response|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|positive regulation of type I interferon-mediated signaling pathway|sequence-specific double-stranded DNA binding|negative regulation of macrophage apoptotic process" "hsa04620,hsa04621,hsa04622,hsa04623,hsa05160,hsa05161,hsa05162,hsa05164,hsa05167,hsa05168,hsa05169,hsa05203" Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Viral carcinogenesis IRF9 486.099652 409.9230698 562.2762343 1.371662821 0.455925885 0.097501953 1 12.29036001 16.57613024 10379 interferon regulatory factor 9 "GO:0000785,GO:0000978,GO:0000981,GO:0002376,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006366,GO:0007166,GO:0051607,GO:0060333,GO:0060337,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|immune system process|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|cell surface receptor signaling pathway|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|sequence-specific double-stranded DNA binding" "hsa04217,hsa04380,hsa04621,hsa04625,hsa04630,hsa05160,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05171,hsa05203" Necroptosis|Osteoclast differentiation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Hepatitis C|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Viral carcinogenesis IRGQ 447.0986083 395.3572754 498.8399412 1.261744686 0.33542001 0.232924618 1 2.178349283 2.70252786 126298 immunity related GTPase Q "GO:0005515,GO:0005525" protein binding|GTP binding IRS1 1851.387934 1885.229955 1817.545913 0.964097726 -0.052748702 0.82578421 1 10.29692537 9.761123379 3667 insulin receptor substrate 1 "GO:0000165,GO:0001784,GO:0005068,GO:0005080,GO:0005158,GO:0005159,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005899,GO:0005901,GO:0007165,GO:0008284,GO:0008286,GO:0010907,GO:0014065,GO:0030159,GO:0032000,GO:0032868,GO:0032869,GO:0038111,GO:0042169,GO:0042593,GO:0043231,GO:0043434,GO:0043548,GO:0043552,GO:0045725,GO:0046326,GO:0046627,GO:0046628,GO:0046676,GO:0048009,GO:0048015,GO:0051897,GO:0071398" MAPK cascade|phosphotyrosine residue binding|transmembrane receptor protein tyrosine kinase adaptor activity|protein kinase C binding|insulin receptor binding|insulin-like growth factor receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|insulin receptor complex|caveola|signal transduction|positive regulation of cell population proliferation|insulin receptor signaling pathway|positive regulation of glucose metabolic process|phosphatidylinositol 3-kinase signaling|signaling receptor complex adaptor activity|positive regulation of fatty acid beta-oxidation|response to insulin|cellular response to insulin stimulus|interleukin-7-mediated signaling pathway|SH2 domain binding|glucose homeostasis|intracellular membrane-bounded organelle|response to peptide hormone|phosphatidylinositol 3-kinase binding|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of glycogen biosynthetic process|positive regulation of glucose import|negative regulation of insulin receptor signaling pathway|positive regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|insulin-like growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein kinase B signaling|cellular response to fatty acid "hsa04022,hsa04068,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04722,hsa04910,hsa04920,hsa04923,hsa04930,hsa04931,hsa04932,hsa04935,hsa04960,hsa05010,hsa05206" "cGMP-PKG signaling pathway|FoxO signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Neurotrophin signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Regulation of lipolysis in adipocytes|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Alzheimer disease|MicroRNAs in cancer" IRS2 606.2875771 600.3188103 612.256344 1.019885323 0.028406944 0.920381482 1 3.928140212 3.939213339 8660 insulin receptor substrate 2 "GO:0000165,GO:0002053,GO:0002903,GO:0005158,GO:0005515,GO:0005829,GO:0005886,GO:0006006,GO:0007165,GO:0007411,GO:0007420,GO:0008284,GO:0008286,GO:0009749,GO:0010748,GO:0010907,GO:0014068,GO:0019216,GO:0019901,GO:0019903,GO:0019904,GO:0030335,GO:0030879,GO:0030890,GO:0032000,GO:0032024,GO:0032869,GO:0032991,GO:0033673,GO:0038111,GO:0043548,GO:0045725,GO:0046326,GO:0046579,GO:0048015,GO:0051897,GO:0055088,GO:0071333,GO:0071889" MAPK cascade|positive regulation of mesenchymal cell proliferation|negative regulation of B cell apoptotic process|insulin receptor binding|protein binding|cytosol|plasma membrane|glucose metabolic process|signal transduction|axon guidance|brain development|positive regulation of cell population proliferation|insulin receptor signaling pathway|response to glucose|negative regulation of long-chain fatty acid import across plasma membrane|positive regulation of glucose metabolic process|positive regulation of phosphatidylinositol 3-kinase signaling|regulation of lipid metabolic process|protein kinase binding|protein phosphatase binding|protein domain specific binding|positive regulation of cell migration|mammary gland development|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of insulin secretion|cellular response to insulin stimulus|protein-containing complex|negative regulation of kinase activity|interleukin-7-mediated signaling pathway|phosphatidylinositol 3-kinase binding|positive regulation of glycogen biosynthetic process|positive regulation of glucose import|positive regulation of Ras protein signal transduction|phosphatidylinositol-mediated signaling|positive regulation of protein kinase B signaling|lipid homeostasis|cellular response to glucose stimulus|14-3-3 protein binding "hsa04022,hsa04068,hsa04140,hsa04152,hsa04211,hsa04213,hsa04910,hsa04920,hsa04923,hsa04930,hsa04931,hsa04932,hsa04935,hsa05010,hsa05206" "cGMP-PKG signaling pathway|FoxO signaling pathway|Autophagy - animal|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Insulin signaling pathway|Adipocytokine signaling pathway|Regulation of lipolysis in adipocytes|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|Growth hormone synthesis, secretion and action|Alzheimer disease|MicroRNAs in cancer" IRS4 39.10986978 42.65696919 35.56277037 0.833691916 -0.262413749 0.717041041 1 0.276310723 0.226503286 8471 insulin receptor substrate 4 "GO:0005158,GO:0005515,GO:0005829,GO:0005886,GO:0007165,GO:0008286,GO:0043548" insulin receptor binding|protein binding|cytosol|plasma membrane|signal transduction|insulin receptor signaling pathway|phosphatidylinositol 3-kinase binding "hsa04022,hsa04068,hsa04140,hsa04152,hsa04211,hsa04213,hsa04910,hsa04920,hsa04923,hsa04930,hsa04935,hsa05010" "cGMP-PKG signaling pathway|FoxO signaling pathway|Autophagy - animal|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Insulin signaling pathway|Adipocytokine signaling pathway|Regulation of lipolysis in adipocytes|Type II diabetes mellitus|Growth hormone synthesis, secretion and action|Alzheimer disease" IRX2 206.5334453 186.234085 226.8328056 1.217998336 0.284512162 0.432353299 1 1.552479043 1.859274957 153572 iroquois homeobox 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0030182,GO:0043565,GO:0048468,GO:0072086,GO:0072272" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|neuron differentiation|sequence-specific DNA binding|cell development|specification of loop of Henle identity|proximal/distal pattern formation involved in metanephric nephron development" IRX3 91.19534497 85.31393838 97.07675156 1.137876804 0.186344368 0.716490032 1 1.622611579 1.815436211 79191 iroquois homeobox 3 "GO:0000785,GO:0000978,GO:0000981,GO:0001656,GO:0005634,GO:0005737,GO:0006357,GO:0007498,GO:0030182,GO:0030424,GO:0045665,GO:0045666,GO:0048468,GO:0072086,GO:0097009,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|metanephros development|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|mesoderm development|neuron differentiation|axon|negative regulation of neuron differentiation|positive regulation of neuron differentiation|cell development|specification of loop of Henle identity|energy homeostasis|sequence-specific double-stranded DNA binding" IRX5 41.83482179 38.49531366 45.17432993 1.173502061 0.230820376 0.747484045 1 0.664862181 0.767161262 10265 iroquois homeobox 5 "GO:0000785,GO:0000978,GO:0000981,GO:0005499,GO:0005634,GO:0006357,GO:0007601,GO:0008406,GO:0030182,GO:0048468,GO:0048701,GO:0050896,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|vitamin D binding|nucleus|regulation of transcription by RNA polymerase II|visual perception|gonad development|neuron differentiation|cell development|embryonic cranial skeleton morphogenesis|response to stimulus|sequence-specific double-stranded DNA binding" ISCA1 436.1491104 435.9334168 436.364804 1.000989571 0.001426944 1 1 11.82763866 11.64122758 81689 iron-sulfur cluster assembly 1 "GO:0005198,GO:0005737,GO:0005739,GO:0005759,GO:0016226,GO:0044281,GO:0046872,GO:0051537,GO:0097428" "structural molecule activity|cytoplasm|mitochondrion|mitochondrial matrix|iron-sulfur cluster assembly|small molecule metabolic process|metal ion binding|2 iron, 2 sulfur cluster binding|protein maturation by iron-sulfur cluster transfer" ISCA2 561.6240077 525.4090107 597.8390046 1.137854495 0.186316083 0.48689708 1 10.86405007 12.15485177 122961 iron-sulfur cluster assembly 2 "GO:0005198,GO:0005506,GO:0005515,GO:0005739,GO:0005759,GO:0016226,GO:0044281,GO:0051537,GO:0051539,GO:0106035" "structural molecule activity|iron ion binding|protein binding|mitochondrion|mitochondrial matrix|iron-sulfur cluster assembly|small molecule metabolic process|2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|protein maturation by [4Fe-4S] cluster transfer" ISCU 817.8796672 755.3404788 880.4188557 1.165592048 0.22106294 0.379446914 1 11.90875424 13.6484737 23479 iron-sulfur cluster assembly enzyme "GO:0005506,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006879,GO:0008198,GO:0016226,GO:0044281,GO:0051537,GO:0051539,GO:0060090,GO:1902958,GO:1904234,GO:1904439" "iron ion binding|protein binding|nucleus|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|cellular iron ion homeostasis|ferrous iron binding|iron-sulfur cluster assembly|small molecule metabolic process|2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|molecular adaptor activity|positive regulation of mitochondrial electron transport, NADH to ubiquinone|positive regulation of aconitate hydratase activity|negative regulation of iron ion import across plasma membrane" ISG15 736.2707297 732.4513734 740.0900861 1.010428969 0.014967907 0.958946038 1 61.3651234 60.96752703 9636 ISG15 ubiquitin like modifier "GO:0005178,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007229,GO:0016032,GO:0016567,GO:0019941,GO:0019985,GO:0022627,GO:0030501,GO:0031386,GO:0031397,GO:0031625,GO:0032020,GO:0032480,GO:0032609,GO:0032613,GO:0032649,GO:0034340,GO:0042742,GO:0045071,GO:0045648,GO:0051607,GO:0060337" integrin binding|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|integrin-mediated signaling pathway|viral process|protein ubiquitination|modification-dependent protein catabolic process|translesion synthesis|cytosolic small ribosomal subunit|positive regulation of bone mineralization|protein tag|negative regulation of protein ubiquitination|ubiquitin protein ligase binding|ISG15-protein conjugation|negative regulation of type I interferon production|interferon-gamma production|interleukin-10 production|regulation of interferon-gamma production|response to type I interferon|defense response to bacterium|negative regulation of viral genome replication|positive regulation of erythrocyte differentiation|defense response to virus|type I interferon signaling pathway "hsa04622,hsa05165,hsa05169,hsa05171" RIG-I-like receptor signaling pathway|Human papillomavirus infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 ISG20 124.49865 126.9304937 122.0668064 0.961682279 -0.056367761 0.915660833 1 1.214204546 1.148139468 3669 interferon stimulated exonuclease gene 20 "GO:0000175,GO:0000738,GO:0004527,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0006401,GO:0008310,GO:0008859,GO:0009615,GO:0015030,GO:0016605,GO:0030619,GO:0030620,GO:0034511,GO:0045071,GO:0046872,GO:0051607,GO:0060337,GO:0090503" "3'-5'-exoribonuclease activity|DNA catabolic process, exonucleolytic|exonuclease activity|nucleus|nucleoplasm|nucleolus|cytoplasm|rRNA processing|RNA catabolic process|single-stranded DNA 3'-5' exodeoxyribonuclease activity|exoribonuclease II activity|response to virus|Cajal body|PML body|U1 snRNA binding|U2 snRNA binding|U3 snoRNA binding|negative regulation of viral genome replication|metal ion binding|defense response to virus|type I interferon signaling pathway|RNA phosphodiester bond hydrolysis, exonucleolytic" ISG20L2 850.850235 927.0087694 774.6917005 0.835689722 -0.258960703 0.3003614 1 14.07475228 11.56530257 81875 interferon stimulated exonuclease gene 20 like 2 "GO:0000175,GO:0003723,GO:0004527,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0090503" "3'-5'-exoribonuclease activity|RNA binding|exonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|rRNA processing|RNA phosphodiester bond hydrolysis, exonucleolytic" ISL2 51.59986679 55.14193578 48.0577978 0.87152903 -0.198379375 0.76360263 1 1.607222155 1.377301266 64843 ISL LIM homeobox 2 "GO:0000785,GO:0000981,GO:0000987,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0007409,GO:0021520,GO:0021524,GO:0031290,GO:0045665,GO:0046872,GO:0048665,GO:0048666,GO:0048935,GO:1990837" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|axonogenesis|spinal cord motor neuron cell fate specification|visceral motor neuron differentiation|retinal ganglion cell axon guidance|negative regulation of neuron differentiation|metal ion binding|neuron fate specification|neuron development|peripheral nervous system neuron development|sequence-specific double-stranded DNA binding" ISM2 5.524131538 6.242483296 4.80577978 0.769850643 -0.377349516 0.927604977 1 0.106166303 0.080364519 145501 isthmin 2 "GO:0005515,GO:0005576" protein binding|extracellular region ISOC1 606.4360321 629.450399 583.4216653 0.926874725 -0.109553736 0.680520743 1 17.29794589 15.76473781 51015 isochorismatase domain containing 1 "GO:0003674,GO:0005515,GO:0005737,GO:0005777,GO:0008150" molecular_function|protein binding|cytoplasm|peroxisome|biological_process ISOC2 568.6490094 583.6721882 553.6258307 0.948521862 -0.076247069 0.779644007 1 27.73776664 25.86961788 79763 isochorismatase domain containing 2 "GO:0005515,GO:0005634,GO:0005737,GO:0031648" protein binding|nucleus|cytoplasm|protein destabilization IST1 3208.077345 3033.846882 3382.307809 1.114857783 0.156859685 0.508360842 1 33.65429892 36.89191477 9798 IST1 factor associated with ESCRT-III "GO:0000785,GO:0005515,GO:0005576,GO:0005635,GO:0005793,GO:0005813,GO:0005829,GO:0008104,GO:0009838,GO:0015031,GO:0019076,GO:0019904,GO:0030496,GO:0035578,GO:0036258,GO:0043231,GO:0043312,GO:0044877,GO:0045184,GO:0045296,GO:0045862,GO:0046745,GO:0048672,GO:0051301,GO:0061640,GO:0070062,GO:0090541,GO:0090543,GO:1904903" chromatin|protein binding|extracellular region|nuclear envelope|endoplasmic reticulum-Golgi intermediate compartment|centrosome|cytosol|protein localization|abscission|protein transport|viral release from host cell|protein domain specific binding|midbody|azurophil granule lumen|multivesicular body assembly|intracellular membrane-bounded organelle|neutrophil degranulation|protein-containing complex binding|establishment of protein localization|cadherin binding|positive regulation of proteolysis|viral capsid secondary envelopment|positive regulation of collateral sprouting|cell division|cytoskeleton-dependent cytokinesis|extracellular exosome|MIT domain binding|Flemming body|ESCRT III complex disassembly hsa04144 Endocytosis ISY1 189.2326381 186.234085 192.2311912 1.03220198 0.045725303 0.916819054 1 2.70227592 2.742619487 57461 ISY1 splicing factor homolog "GO:0000350,GO:0000389,GO:0000398,GO:0000974,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006283,GO:0071006,GO:0071013,GO:0071014,GO:0071020" "generation of catalytic spliceosome for second transesterification step|mRNA 3'-splice site recognition|mRNA splicing, via spliceosome|Prp19 complex|RNA binding|protein binding|nucleus|nucleoplasm|transcription-coupled nucleotide-excision repair|U2-type catalytic step 1 spliceosome|catalytic step 2 spliceosome|post-mRNA release spliceosomal complex|post-spliceosomal complex" hsa03040 Spliceosome ISYNA1 217.3043056 191.4361544 243.1724569 1.270253561 0.345116509 0.329622343 1 3.953790912 4.938275312 51477 inositol-3-phosphate synthase 1 "GO:0004512,GO:0005515,GO:0005737,GO:0005829,GO:0006021,GO:0008654,GO:0043647" inositol-3-phosphate synthase activity|protein binding|cytoplasm|cytosol|inositol biosynthetic process|phospholipid biosynthetic process|inositol phosphate metabolic process hsa00562 Inositol phosphate metabolism ITCH 4971.440252 4916.996009 5025.884494 1.022145327 0.031600331 0.896032285 1 29.3393381 29.48724091 83737 itchy E3 ubiquitin protein ligase "GO:0000209,GO:0001558,GO:0004842,GO:0005515,GO:0005654,GO:0005737,GO:0005769,GO:0005829,GO:0005886,GO:0006511,GO:0006915,GO:0006954,GO:0007219,GO:0016020,GO:0016567,GO:0031410,GO:0031901,GO:0032088,GO:0032480,GO:0032991,GO:0035519,GO:0043021,GO:0043066,GO:0043161,GO:0043231,GO:0044389,GO:0045087,GO:0045236,GO:0045732,GO:0046329,GO:0046718,GO:0050687,GO:0051607,GO:0051865,GO:0061630,GO:0070062,GO:0070423,GO:0070534,GO:0070936,GO:0090085,GO:1902036,GO:1990763,GO:2000646" protein polyubiquitination|regulation of cell growth|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytoplasm|early endosome|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|apoptotic process|inflammatory response|Notch signaling pathway|membrane|protein ubiquitination|cytoplasmic vesicle|early endosome membrane|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein-containing complex|protein K29-linked ubiquitination|ribonucleoprotein complex binding|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|ubiquitin-like protein ligase binding|innate immune response|CXCR chemokine receptor binding|positive regulation of protein catabolic process|negative regulation of JNK cascade|viral entry into host cell|negative regulation of defense response to virus|defense response to virus|protein autoubiquitination|ubiquitin protein ligase activity|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|protein K63-linked ubiquitination|protein K48-linked ubiquitination|regulation of protein deubiquitination|regulation of hematopoietic stem cell differentiation|arrestin family protein binding|positive regulation of receptor catabolic process "hsa04120,hsa04144,hsa04668,hsa04932" Ubiquitin mediated proteolysis|Endocytosis|TNF signaling pathway|Non-alcoholic fatty liver disease ITFG1 1190.543409 1114.283268 1266.80355 1.136877476 0.18507678 0.445893148 1 17.92802233 20.0409002 81533 integrin alpha FG-GAP repeat containing 1 "GO:0005886,GO:0016021,GO:0070062" plasma membrane|integral component of membrane|extracellular exosome ITFG2 195.5940083 201.8402932 189.3477233 0.93810666 -0.092176133 0.813748354 1 4.611235224 4.25344356 55846 integrin alpha FG-GAP repeat containing 2 "GO:0002314,GO:0005654,GO:0005765,GO:0005829,GO:0032006,GO:0034198,GO:0042149,GO:0140007,GO:1904262" germinal center B cell differentiation|nucleoplasm|lysosomal membrane|cytosol|regulation of TOR signaling|cellular response to amino acid starvation|cellular response to glucose starvation|KICSTOR complex|negative regulation of TORC1 signaling ITGA1 1046.349894 1164.223135 928.4766535 0.797507476 -0.326430052 0.18242077 1 5.787299641 4.538182014 3672 integrin subunit alpha 1 "GO:0000187,GO:0001669,GO:0005102,GO:0005515,GO:0005518,GO:0005886,GO:0005925,GO:0006936,GO:0007160,GO:0007229,GO:0008285,GO:0008305,GO:0009897,GO:0009986,GO:0016020,GO:0019903,GO:0030198,GO:0030593,GO:0032516,GO:0034665,GO:0042059,GO:0042311,GO:0043005,GO:0043204,GO:0043525,GO:0045121,GO:0045123,GO:0045178,GO:0046872,GO:0048812,GO:0070062,GO:0098639" activation of MAPK activity|acrosomal vesicle|signaling receptor binding|protein binding|collagen binding|plasma membrane|focal adhesion|muscle contraction|cell-matrix adhesion|integrin-mediated signaling pathway|negative regulation of cell population proliferation|integrin complex|external side of plasma membrane|cell surface|membrane|protein phosphatase binding|extracellular matrix organization|neutrophil chemotaxis|positive regulation of phosphoprotein phosphatase activity|integrin alpha1-beta1 complex|negative regulation of epidermal growth factor receptor signaling pathway|vasodilation|neuron projection|perikaryon|positive regulation of neuron apoptotic process|membrane raft|cellular extravasation|basal part of cell|metal ion binding|neuron projection morphogenesis|extracellular exosome|collagen binding involved in cell-matrix adhesion "hsa04151,hsa04510,hsa04512,hsa04640,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGA10 13.49078193 13.52538047 13.45618338 0.994883908 -0.007399906 1 1 0.13367124 0.130762002 8515 integrin subunit alpha 10 "GO:0005518,GO:0005886,GO:0007160,GO:0007229,GO:0008305,GO:0030198,GO:0034680,GO:0046872,GO:0098639" collagen binding|plasma membrane|cell-matrix adhesion|integrin-mediated signaling pathway|integrin complex|extracellular matrix organization|integrin alpha10-beta1 complex|metal ion binding|collagen binding involved in cell-matrix adhesion "hsa04151,hsa04510,hsa04512,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGA11 6.202854333 11.44455271 0.961155956 0.083983707 -3.573746729 0.041121017 1 0.055962502 0.004621291 22801 integrin subunit alpha 11 "GO:0001649,GO:0005518,GO:0005886,GO:0005925,GO:0006929,GO:0007155,GO:0007160,GO:0007229,GO:0007517,GO:0008305,GO:0016020,GO:0030198,GO:0033627,GO:0034681,GO:0038064,GO:0038065,GO:0046872,GO:0098639" osteoblast differentiation|collagen binding|plasma membrane|focal adhesion|substrate-dependent cell migration|cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|integrin complex|membrane|extracellular matrix organization|cell adhesion mediated by integrin|integrin alpha11-beta1 complex|collagen receptor activity|collagen-activated signaling pathway|metal ion binding|collagen binding involved in cell-matrix adhesion "hsa04151,hsa04510,hsa04512,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGA2 8428.77022 7769.810876 9087.729564 1.169620433 0.226040421 0.361515682 1 52.87014231 60.8032236 3673 integrin subunit alpha 2 "GO:0001540,GO:0001618,GO:0001666,GO:0002687,GO:0005178,GO:0005515,GO:0005518,GO:0005634,GO:0005886,GO:0005925,GO:0006929,GO:0006971,GO:0007155,GO:0007160,GO:0007229,GO:0007565,GO:0007596,GO:0008283,GO:0008305,GO:0009887,GO:0009897,GO:0009986,GO:0010634,GO:0010694,GO:0014075,GO:0014850,GO:0014911,GO:0030198,GO:0030879,GO:0031346,GO:0031589,GO:0032967,GO:0033343,GO:0033591,GO:0033627,GO:0034666,GO:0038064,GO:0038065,GO:0042493,GO:0043236,GO:0043388,GO:0043395,GO:0043589,GO:0043679,GO:0044877,GO:0045178,GO:0045184,GO:0045727,GO:0045785,GO:0045987,GO:0046718,GO:0046872,GO:0048041,GO:0048333,GO:0048471,GO:0048661,GO:0050729,GO:0050927,GO:0050966,GO:0051971,GO:0060100,GO:0070365,GO:0071107,GO:0071260,GO:0071392,GO:0098639" "amyloid-beta binding|virus receptor activity|response to hypoxia|positive regulation of leukocyte migration|integrin binding|protein binding|collagen binding|nucleus|plasma membrane|focal adhesion|substrate-dependent cell migration|hypotonic response|cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|female pregnancy|blood coagulation|cell population proliferation|integrin complex|animal organ morphogenesis|external side of plasma membrane|cell surface|positive regulation of epithelial cell migration|positive regulation of alkaline phosphatase activity|response to amine|response to muscle activity|positive regulation of smooth muscle cell migration|extracellular matrix organization|mammary gland development|positive regulation of cell projection organization|cell-substrate adhesion|positive regulation of collagen biosynthetic process|positive regulation of collagen binding|response to L-ascorbic acid|cell adhesion mediated by integrin|integrin alpha2-beta1 complex|collagen receptor activity|collagen-activated signaling pathway|response to drug|laminin binding|positive regulation of DNA binding|heparan sulfate proteoglycan binding|skin morphogenesis|axon terminus|protein-containing complex binding|basal part of cell|establishment of protein localization|positive regulation of translation|positive regulation of cell adhesion|positive regulation of smooth muscle contraction|viral entry into host cell|metal ion binding|focal adhesion assembly|mesodermal cell differentiation|perinuclear region of cytoplasm|positive regulation of smooth muscle cell proliferation|positive regulation of inflammatory response|positive regulation of positive chemotaxis|detection of mechanical stimulus involved in sensory perception of pain|positive regulation of transmission of nerve impulse|positive regulation of phagocytosis, engulfment|hepatocyte differentiation|response to parathyroid hormone|cellular response to mechanical stimulus|cellular response to estradiol stimulus|collagen binding involved in cell-matrix adhesion" "hsa04145,hsa04151,hsa04510,hsa04512,hsa04611,hsa04640,hsa04810,hsa05165,hsa05200,hsa05205,hsa05222,hsa05410,hsa05412,hsa05414" Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Platelet activation|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGA2B 21.9380103 20.80827765 23.06774294 1.108584926 0.148719296 0.913376404 1 0.332983369 0.362963279 3674 integrin subunit alpha 2b "GO:0002576,GO:0002687,GO:0005515,GO:0005886,GO:0005925,GO:0007160,GO:0007229,GO:0008305,GO:0009897,GO:0009986,GO:0030198,GO:0031092,GO:0042802,GO:0045652,GO:0046872,GO:0050840,GO:0070051,GO:0070062,GO:0070527,GO:0072562" platelet degranulation|positive regulation of leukocyte migration|protein binding|plasma membrane|focal adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|integrin complex|external side of plasma membrane|cell surface|extracellular matrix organization|platelet alpha granule membrane|identical protein binding|regulation of megakaryocyte differentiation|metal ion binding|extracellular matrix binding|fibrinogen binding|extracellular exosome|platelet aggregation|blood microparticle "hsa04015,hsa04151,hsa04510,hsa04512,hsa04611,hsa04640,hsa04810,hsa05165,hsa05200,hsa05222,hsa05410,hsa05412,hsa05414,hsa05418" Rap1 signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Platelet activation|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Fluid shear stress and atherosclerosis ITGA3 27370.26666 27956.96144 26783.57187 0.958028716 -0.061859195 0.829738129 1 302.3939297 284.8542964 3675 integrin subunit alpha 3 "GO:0001764,GO:0001968,GO:0002020,GO:0005178,GO:0005515,GO:0005518,GO:0005886,GO:0005925,GO:0007160,GO:0007229,GO:0007507,GO:0007613,GO:0008305,GO:0009897,GO:0009986,GO:0010628,GO:0010634,GO:0010811,GO:0010976,GO:0016323,GO:0017015,GO:0019904,GO:0030111,GO:0030198,GO:0030324,GO:0030510,GO:0031345,GO:0031527,GO:0034667,GO:0034698,GO:0035024,GO:0035640,GO:0042493,GO:0043235,GO:0043236,GO:0043588,GO:0046872,GO:0046982,GO:0048333,GO:0048471,GO:0050900,GO:0060076,GO:0060135,GO:0070062,GO:0071438,GO:0071944,GO:0072006,GO:0097060,GO:0097062,GO:0097205,GO:1903078,GO:1990812" neuron migration|fibronectin binding|protease binding|integrin binding|protein binding|collagen binding|plasma membrane|focal adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|heart development|memory|integrin complex|external side of plasma membrane|cell surface|positive regulation of gene expression|positive regulation of epithelial cell migration|positive regulation of cell-substrate adhesion|positive regulation of neuron projection development|basolateral plasma membrane|regulation of transforming growth factor beta receptor signaling pathway|protein domain specific binding|regulation of Wnt signaling pathway|extracellular matrix organization|lung development|regulation of BMP signaling pathway|negative regulation of cell projection organization|filopodium membrane|integrin alpha3-beta1 complex|response to gonadotropin|negative regulation of Rho protein signal transduction|exploration behavior|response to drug|receptor complex|laminin binding|skin development|metal ion binding|protein heterodimerization activity|mesodermal cell differentiation|perinuclear region of cytoplasm|leukocyte migration|excitatory synapse|maternal process involved in female pregnancy|extracellular exosome|invadopodium membrane|cell periphery|nephron development|synaptic membrane|dendritic spine maintenance|renal filtration|positive regulation of protein localization to plasma membrane|growth cone filopodium "hsa04151,hsa04510,hsa04512,hsa04640,hsa04810,hsa05165,hsa05200,hsa05222,hsa05410,hsa05412,hsa05414" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGA5 4148.005656 4331.242993 3964.768318 0.915388106 -0.127544549 0.593005846 1 53.51944387 48.17126325 3678 integrin subunit alpha 5 "GO:0001525,GO:0001618,GO:0001726,GO:0005154,GO:0005161,GO:0005178,GO:0005515,GO:0005783,GO:0005794,GO:0005886,GO:0005911,GO:0005925,GO:0007044,GO:0007155,GO:0007157,GO:0007159,GO:0007229,GO:0007565,GO:0007613,GO:0008305,GO:0009897,GO:0009986,GO:0010811,GO:0023035,GO:0030198,GO:0030335,GO:0030949,GO:0031410,GO:0031589,GO:0032587,GO:0033627,GO:0033631,GO:0034113,GO:0034674,GO:0035313,GO:0035987,GO:0043184,GO:0045202,GO:0046718,GO:0046872,GO:0050731,GO:0050900,GO:0071062,GO:1903672,GO:2000811" "angiogenesis|virus receptor activity|ruffle|epidermal growth factor receptor binding|platelet-derived growth factor receptor binding|integrin binding|protein binding|endoplasmic reticulum|Golgi apparatus|plasma membrane|cell-cell junction|focal adhesion|cell-substrate junction assembly|cell adhesion|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|leukocyte cell-cell adhesion|integrin-mediated signaling pathway|female pregnancy|memory|integrin complex|external side of plasma membrane|cell surface|positive regulation of cell-substrate adhesion|CD40 signaling pathway|extracellular matrix organization|positive regulation of cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|cytoplasmic vesicle|cell-substrate adhesion|ruffle membrane|cell adhesion mediated by integrin|cell-cell adhesion mediated by integrin|heterotypic cell-cell adhesion|integrin alpha5-beta1 complex|wound healing, spreading of epidermal cells|endodermal cell differentiation|vascular endothelial growth factor receptor 2 binding|synapse|viral entry into host cell|metal ion binding|positive regulation of peptidyl-tyrosine phosphorylation|leukocyte migration|alphav-beta3 integrin-vitronectin complex|positive regulation of sprouting angiogenesis|negative regulation of anoikis" "hsa04145,hsa04151,hsa04510,hsa04512,hsa04640,hsa04810,hsa05100,hsa05131,hsa05133,hsa05135,hsa05165,hsa05168,hsa05205,hsa05206,hsa05410,hsa05412,hsa05414" Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Shigellosis|Pertussis|Yersinia infection|Human papillomavirus infection|Herpes simplex virus 1 infection|Proteoglycans in cancer|MicroRNAs in cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGA6 9960.724596 8485.615627 11435.83356 1.347672823 0.430470293 0.08698986 1 75.18872823 99.63418854 3655 integrin subunit alpha 6 "GO:0005515,GO:0005886,GO:0005912,GO:0005925,GO:0007044,GO:0007229,GO:0009986,GO:0010668,GO:0010811,GO:0010976,GO:0030175,GO:0030198,GO:0030335,GO:0031581,GO:0031589,GO:0031994,GO:0034676,GO:0035878,GO:0038132,GO:0042327,GO:0043065,GO:0043236,GO:0043547,GO:0043589,GO:0044877,GO:0045296,GO:0045944,GO:0046872,GO:0050900,GO:0071407,GO:0098609,GO:2001237" protein binding|plasma membrane|adherens junction|focal adhesion|cell-substrate junction assembly|integrin-mediated signaling pathway|cell surface|ectodermal cell differentiation|positive regulation of cell-substrate adhesion|positive regulation of neuron projection development|filopodium|extracellular matrix organization|positive regulation of cell migration|hemidesmosome assembly|cell-substrate adhesion|insulin-like growth factor I binding|integrin alpha6-beta4 complex|nail development|neuregulin binding|positive regulation of phosphorylation|positive regulation of apoptotic process|laminin binding|positive regulation of GTPase activity|skin morphogenesis|protein-containing complex binding|cadherin binding|positive regulation of transcription by RNA polymerase II|metal ion binding|leukocyte migration|cellular response to organic cyclic compound|cell-cell adhesion|negative regulation of extrinsic apoptotic signaling pathway "hsa04151,hsa04510,hsa04512,hsa04514,hsa04640,hsa04810,hsa05145,hsa05165,hsa05200,hsa05222,hsa05410,hsa05412,hsa05414" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Cell adhesion molecules|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Toxoplasmosis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGA7 811.5686012 614.8846046 1008.252598 1.639742791 0.713469532 0.004613265 0.412329403 6.953859131 11.21173431 3679 integrin subunit alpha 7 "GO:0005515,GO:0005886,GO:0007160,GO:0007229,GO:0007517,GO:0008305,GO:0008360,GO:0009986,GO:0030198,GO:0034113,GO:0035987,GO:0046872" protein binding|plasma membrane|cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|integrin complex|regulation of cell shape|cell surface|extracellular matrix organization|heterotypic cell-cell adhesion|endodermal cell differentiation|metal ion binding "hsa04151,hsa04510,hsa04512,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGAE 268.1858207 240.3356069 296.0360344 1.231761029 0.300722389 0.360555397 1 2.232985658 2.704478741 3682 integrin subunit alpha E "GO:0005886,GO:0007155,GO:0007229,GO:0008305,GO:0009897,GO:0030198,GO:0046872" plasma membrane|cell adhesion|integrin-mediated signaling pathway|integrin complex|external side of plasma membrane|extracellular matrix organization|metal ion binding hsa04810 Regulation of actin cytoskeleton ITGAV 5227.733083 5551.648478 4903.817687 0.883308392 -0.179010877 0.456806484 1 41.05893511 35.66081106 3685 integrin subunit alpha V "GO:0001525,GO:0001570,GO:0001618,GO:0001846,GO:0001968,GO:0002020,GO:0002479,GO:0005080,GO:0005178,GO:0005245,GO:0005515,GO:0005829,GO:0005886,GO:0005887,GO:0005925,GO:0007155,GO:0007160,GO:0007204,GO:0007229,GO:0008284,GO:0008305,GO:0009897,GO:0009986,GO:0010745,GO:0010888,GO:0015026,GO:0016020,GO:0017134,GO:0019960,GO:0030198,GO:0030335,GO:0031258,GO:0031527,GO:0031528,GO:0031589,GO:0031994,GO:0032369,GO:0032587,GO:0033627,GO:0033690,GO:0034113,GO:0034446,GO:0034683,GO:0034684,GO:0034685,GO:0034686,GO:0035579,GO:0035866,GO:0035867,GO:0035868,GO:0035987,GO:0038027,GO:0038132,GO:0043277,GO:0043312,GO:0045335,GO:0045785,GO:0046718,GO:0046872,GO:0048010,GO:0050431,GO:0050748,GO:0050764,GO:0050840,GO:0050900,GO:0050919,GO:0070062,GO:0070371,GO:0070588,GO:0071604,GO:0085017,GO:0097192,GO:1901388,GO:1905598,GO:1990430,GO:2000536,GO:2001237" "angiogenesis|vasculogenesis|virus receptor activity|opsonin binding|fibronectin binding|protease binding|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein kinase C binding|integrin binding|voltage-gated calcium channel activity|protein binding|cytosol|plasma membrane|integral component of plasma membrane|focal adhesion|cell adhesion|cell-matrix adhesion|positive regulation of cytosolic calcium ion concentration|integrin-mediated signaling pathway|positive regulation of cell population proliferation|integrin complex|external side of plasma membrane|cell surface|negative regulation of macrophage derived foam cell differentiation|negative regulation of lipid storage|coreceptor activity|membrane|fibroblast growth factor binding|C-X3-C chemokine binding|extracellular matrix organization|positive regulation of cell migration|lamellipodium membrane|filopodium membrane|microvillus membrane|cell-substrate adhesion|insulin-like growth factor I binding|negative regulation of lipid transport|ruffle membrane|cell adhesion mediated by integrin|positive regulation of osteoblast proliferation|heterotypic cell-cell adhesion|substrate adhesion-dependent cell spreading|integrin alphav-beta3 complex|integrin alphav-beta5 complex|integrin alphav-beta6 complex|integrin alphav-beta8 complex|specific granule membrane|alphav-beta3 integrin-PKCalpha complex|alphav-beta3 integrin-IGF-1-IGF1R complex|alphav-beta3 integrin-HMGB1 complex|endodermal cell differentiation|apolipoprotein A-I-mediated signaling pathway|neuregulin binding|apoptotic cell clearance|neutrophil degranulation|phagocytic vesicle|positive regulation of cell adhesion|viral entry into host cell|metal ion binding|vascular endothelial growth factor receptor signaling pathway|transforming growth factor beta binding|negative regulation of lipoprotein metabolic process|regulation of phagocytosis|extracellular matrix binding|leukocyte migration|negative chemotaxis|extracellular exosome|ERK1 and ERK2 cascade|calcium ion transmembrane transport|transforming growth factor beta production|entry into host cell by a symbiont-containing vacuole|extrinsic apoptotic signaling pathway in absence of ligand|regulation of transforming growth factor beta activation|negative regulation of low-density lipoprotein receptor activity|extracellular matrix protein binding|negative regulation of entry of bacterium into host cell|negative regulation of extrinsic apoptotic signaling pathway" "hsa04145,hsa04151,hsa04510,hsa04512,hsa04514,hsa04810,hsa04919,hsa05163,hsa05165,hsa05200,hsa05205,hsa05222,hsa05410,hsa05412,hsa05414,hsa05418" Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Cell adhesion molecules|Regulation of actin cytoskeleton|Thyroid hormone signaling pathway|Human cytomegalovirus infection|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Fluid shear stress and atherosclerosis ITGAX 4.122026567 7.282897178 0.961155956 0.131974396 -2.921670032 0.166282975 1 0.078094201 0.010133971 3687 integrin subunit alpha X "GO:0005178,GO:0005515,GO:0005886,GO:0007155,GO:0007229,GO:0008284,GO:0008305,GO:0009887,GO:0009986,GO:0010628,GO:0016020,GO:0019221,GO:0030198,GO:0030335,GO:0030667,GO:0030971,GO:0031643,GO:0034113,GO:0034689,GO:0038023,GO:0043312,GO:0045766,GO:0046872,GO:0050900,GO:0070821,GO:0101003,GO:1905956" integrin binding|protein binding|plasma membrane|cell adhesion|integrin-mediated signaling pathway|positive regulation of cell population proliferation|integrin complex|animal organ morphogenesis|cell surface|positive regulation of gene expression|membrane|cytokine-mediated signaling pathway|extracellular matrix organization|positive regulation of cell migration|secretory granule membrane|receptor tyrosine kinase binding|positive regulation of myelination|heterotypic cell-cell adhesion|integrin alphaX-beta2 complex|signaling receptor activity|neutrophil degranulation|positive regulation of angiogenesis|metal ion binding|leukocyte migration|tertiary granule membrane|ficolin-1-rich granule membrane|positive regulation of endothelial tube morphogenesis "hsa04610,hsa04810,hsa05152" Complement and coagulation cascades|Regulation of actin cytoskeleton|Tuberculosis ITGB1 26509.58759 25283.09776 27736.07742 1.097020535 0.133590531 0.640410777 1 335.7333812 362.1433043 3688 integrin subunit beta 1 "GO:0000132,GO:0001618,GO:0001726,GO:0001968,GO:0002020,GO:0003779,GO:0005178,GO:0005515,GO:0005737,GO:0005886,GO:0005925,GO:0006909,GO:0006968,GO:0007155,GO:0007156,GO:0007159,GO:0007160,GO:0007161,GO:0007179,GO:0007229,GO:0008305,GO:0009986,GO:0010710,GO:0010763,GO:0015026,GO:0016020,GO:0016477,GO:0019221,GO:0019960,GO:0023035,GO:0030027,GO:0030030,GO:0030032,GO:0030175,GO:0030183,GO:0030198,GO:0030335,GO:0031589,GO:0031594,GO:0031623,GO:0032154,GO:0032587,GO:0033627,GO:0033631,GO:0034113,GO:0034665,GO:0034666,GO:0034667,GO:0034668,GO:0034674,GO:0034678,GO:0034680,GO:0034681,GO:0035633,GO:0042383,GO:0042470,GO:0043065,GO:0043149,GO:0043235,GO:0043236,GO:0043547,GO:0044877,GO:0045121,GO:0045296,GO:0045766,GO:0046718,GO:0046872,GO:0046982,GO:0048333,GO:0048471,GO:0050776,GO:0050839,GO:0050900,GO:0050901,GO:0051897,GO:0051951,GO:0055037,GO:0070062,GO:0071404,GO:0071438,GO:0090303,GO:0097386,GO:0098639,GO:0150003,GO:0150103,GO:1901979,GO:1903078,GO:1990782,GO:2000273,GO:2000811" establishment of mitotic spindle orientation|virus receptor activity|ruffle|fibronectin binding|protease binding|actin binding|integrin binding|protein binding|cytoplasm|plasma membrane|focal adhesion|phagocytosis|cellular defense response|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|leukocyte cell-cell adhesion|cell-matrix adhesion|calcium-independent cell-matrix adhesion|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|integrin complex|cell surface|regulation of collagen catabolic process|positive regulation of fibroblast migration|coreceptor activity|membrane|cell migration|cytokine-mediated signaling pathway|C-X3-C chemokine binding|CD40 signaling pathway|lamellipodium|cell projection organization|lamellipodium assembly|filopodium|B cell differentiation|extracellular matrix organization|positive regulation of cell migration|cell-substrate adhesion|neuromuscular junction|receptor internalization|cleavage furrow|ruffle membrane|cell adhesion mediated by integrin|cell-cell adhesion mediated by integrin|heterotypic cell-cell adhesion|integrin alpha1-beta1 complex|integrin alpha2-beta1 complex|integrin alpha3-beta1 complex|integrin alpha4-beta1 complex|integrin alpha5-beta1 complex|integrin alpha8-beta1 complex|integrin alpha10-beta1 complex|integrin alpha11-beta1 complex|maintenance of blood-brain barrier|sarcolemma|melanosome|positive regulation of apoptotic process|stress fiber assembly|receptor complex|laminin binding|positive regulation of GTPase activity|protein-containing complex binding|membrane raft|cadherin binding|positive regulation of angiogenesis|viral entry into host cell|metal ion binding|protein heterodimerization activity|mesodermal cell differentiation|perinuclear region of cytoplasm|regulation of immune response|cell adhesion molecule binding|leukocyte migration|leukocyte tethering or rolling|positive regulation of protein kinase B signaling|positive regulation of glutamate uptake involved in transmission of nerve impulse|recycling endosome|extracellular exosome|cellular response to low-density lipoprotein particle stimulus|invadopodium membrane|positive regulation of wound healing|glial cell projection|collagen binding involved in cell-matrix adhesion|regulation of spontaneous synaptic transmission|reactive gliosis|regulation of inward rectifier potassium channel activity|positive regulation of protein localization to plasma membrane|protein tyrosine kinase binding|positive regulation of signaling receptor activity|negative regulation of anoikis "hsa04015,hsa04145,hsa04151,hsa04360,hsa04510,hsa04512,hsa04514,hsa04530,hsa04611,hsa04670,hsa04810,hsa05100,hsa05130,hsa05131,hsa05133,hsa05135,hsa05140,hsa05145,hsa05165,hsa05200,hsa05205,hsa05222,hsa05410,hsa05412,hsa05414" Rap1 signaling pathway|Phagosome|PI3K-Akt signaling pathway|Axon guidance|Focal adhesion|ECM-receptor interaction|Cell adhesion molecules|Tight junction|Platelet activation|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Pertussis|Yersinia infection|Leishmaniasis|Toxoplasmosis|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGB1BP1 1033.69758 958.2211859 1109.173973 1.157534387 0.211055053 0.390044377 1 8.08897557 9.206585781 9270 integrin subunit beta 1 binding protein 1 "GO:0001726,GO:0002043,GO:0005092,GO:0005178,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0006469,GO:0006933,GO:0007160,GO:0007219,GO:0007229,GO:0008284,GO:0008285,GO:0010595,GO:0010764,GO:0016020,GO:0016477,GO:0016604,GO:0030027,GO:0030154,GO:0031214,GO:0032091,GO:0032148,GO:0033622,GO:0033628,GO:0034451,GO:0035148,GO:0035556,GO:0035924,GO:0043087,GO:0043113,GO:0044344,GO:0045747,GO:0045944,GO:0048471,GO:0051451,GO:0051496,GO:0051781,GO:0051895,GO:0051897,GO:0070373,GO:0071944,GO:0072659,GO:0090051,GO:0090314,GO:0090315,GO:0097746,GO:1900025,GO:2001044" ruffle|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|GDP-dissociation inhibitor activity|integrin binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|plasma membrane|focal adhesion|negative regulation of protein kinase activity|negative regulation of cell adhesion involved in substrate-bound cell migration|cell-matrix adhesion|Notch signaling pathway|integrin-mediated signaling pathway|positive regulation of cell population proliferation|negative regulation of cell population proliferation|positive regulation of endothelial cell migration|negative regulation of fibroblast migration|membrane|cell migration|nuclear body|lamellipodium|cell differentiation|biomineral tissue development|negative regulation of protein binding|activation of protein kinase B activity|integrin activation|regulation of cell adhesion mediated by integrin|centriolar satellite|tube formation|intracellular signal transduction|cellular response to vascular endothelial growth factor stimulus|regulation of GTPase activity|receptor clustering|cellular response to fibroblast growth factor stimulus|positive regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|myoblast migration|positive regulation of stress fiber assembly|positive regulation of cell division|negative regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|negative regulation of ERK1 and ERK2 cascade|cell periphery|protein localization to plasma membrane|negative regulation of cell migration involved in sprouting angiogenesis|positive regulation of protein targeting to membrane|negative regulation of protein targeting to membrane|blood vessel diameter maintenance|negative regulation of substrate adhesion-dependent cell spreading|regulation of integrin-mediated signaling pathway ITGB1BP2 10.92937619 9.363724944 12.49502743 1.334407781 0.416199607 0.772652545 1 0.390409993 0.512248469 26548 integrin subunit beta 1 binding protein 2 "GO:0005178,GO:0005509,GO:0005515,GO:0007165,GO:0007517,GO:0008270,GO:0017124,GO:0030018" integrin binding|calcium ion binding|protein binding|signal transduction|muscle organ development|zinc ion binding|SH3 domain binding|Z disc ITGB2 153.1993506 161.2641518 145.1345494 0.899980236 -0.152034776 0.717378657 1 2.740009994 2.424690426 3689 integrin subunit beta 2 "GO:0001540,GO:0001774,GO:0001851,GO:0002523,GO:0005178,GO:0005515,GO:0005886,GO:0005925,GO:0006898,GO:0006911,GO:0006915,GO:0006954,GO:0007155,GO:0007159,GO:0007160,GO:0007229,GO:0007267,GO:0007568,GO:0008305,GO:0008360,GO:0009897,GO:0009986,GO:0016020,GO:0016477,GO:0019221,GO:0019901,GO:0030101,GO:0030198,GO:0030369,GO:0030593,GO:0031072,GO:0031623,GO:0032930,GO:0033627,GO:0034113,GO:0034142,GO:0034687,GO:0034688,GO:0034689,GO:0035579,GO:0035987,GO:0038024,GO:0043113,GO:0043235,GO:0043312,GO:0043315,GO:0043542,GO:0044853,GO:0045123,GO:0045429,GO:0045766,GO:0045963,GO:0046872,GO:0050730,GO:0050776,GO:0050839,GO:0050900,GO:0051092,GO:0070062,GO:0070821,GO:0071404,GO:0090314,GO:0097242,GO:0098609,GO:0098742,GO:0099568,GO:0101003,GO:1901216,GO:1903561,GO:1904996,GO:1990266,GO:2000363" "amyloid-beta binding|microglial cell activation|complement component C3b binding|leukocyte migration involved in inflammatory response|integrin binding|protein binding|plasma membrane|focal adhesion|receptor-mediated endocytosis|phagocytosis, engulfment|apoptotic process|inflammatory response|cell adhesion|leukocyte cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|cell-cell signaling|aging|integrin complex|regulation of cell shape|external side of plasma membrane|cell surface|membrane|cell migration|cytokine-mediated signaling pathway|protein kinase binding|natural killer cell activation|extracellular matrix organization|ICAM-3 receptor activity|neutrophil chemotaxis|heat shock protein binding|receptor internalization|positive regulation of superoxide anion generation|cell adhesion mediated by integrin|heterotypic cell-cell adhesion|toll-like receptor 4 signaling pathway|integrin alphaL-beta2 complex|integrin alphaM-beta2 complex|integrin alphaX-beta2 complex|specific granule membrane|endodermal cell differentiation|cargo receptor activity|receptor clustering|receptor complex|neutrophil degranulation|positive regulation of neutrophil degranulation|endothelial cell migration|plasma membrane raft|cellular extravasation|positive regulation of nitric oxide biosynthetic process|positive regulation of angiogenesis|negative regulation of dopamine metabolic process|metal ion binding|regulation of peptidyl-tyrosine phosphorylation|regulation of immune response|cell adhesion molecule binding|leukocyte migration|positive regulation of NF-kappaB transcription factor activity|extracellular exosome|tertiary granule membrane|cellular response to low-density lipoprotein particle stimulus|positive regulation of protein targeting to membrane|amyloid-beta clearance|cell-cell adhesion|cell-cell adhesion via plasma-membrane adhesion molecules|cytoplasmic region|ficolin-1-rich granule membrane|positive regulation of neuron death|extracellular vesicle|positive regulation of leukocyte adhesion to vascular endothelial cell|neutrophil migration|positive regulation of prostaglandin-E synthase activity" "hsa04015,hsa04145,hsa04390,hsa04514,hsa04610,hsa04650,hsa04670,hsa04810,hsa05133,hsa05134,hsa05140,hsa05144,hsa05146,hsa05150,hsa05152,hsa05166,hsa05323,hsa05416" Rap1 signaling pathway|Phagosome|Hippo signaling pathway|Cell adhesion molecules|Complement and coagulation cascades|Natural killer cell mediated cytotoxicity|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Pertussis|Legionellosis|Leishmaniasis|Malaria|Amoebiasis|Staphylococcus aureus infection|Tuberculosis|Human T-cell leukemia virus 1 infection|Rheumatoid arthritis|Viral myocarditis ITGB3 1291.255964 1234.971279 1347.54065 1.091151409 0.125851304 0.602844454 1 11.09378006 11.90243307 3690 integrin subunit beta 3 "GO:0001618,GO:0001934,GO:0001938,GO:0001968,GO:0002020,GO:0002576,GO:0003756,GO:0005161,GO:0005178,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0005887,GO:0005911,GO:0005925,GO:0007155,GO:0007160,GO:0007229,GO:0007596,GO:0008305,GO:0009986,GO:0010595,GO:0010745,GO:0010888,GO:0014909,GO:0015026,GO:0016477,GO:0017134,GO:0018215,GO:0019899,GO:0019960,GO:0030168,GO:0030198,GO:0030949,GO:0031092,GO:0031258,GO:0031527,GO:0031528,GO:0031589,GO:0031994,GO:0032147,GO:0032369,GO:0032587,GO:0032880,GO:0032991,GO:0033627,GO:0034113,GO:0034446,GO:0034683,GO:0035295,GO:0035866,GO:0035867,GO:0035868,GO:0038027,GO:0038132,GO:0042060,GO:0042470,GO:0042802,GO:0043184,GO:0043235,GO:0043277,GO:0045124,GO:0045202,GO:0045211,GO:0046718,GO:0048010,GO:0048333,GO:0050731,GO:0050748,GO:0050839,GO:0050840,GO:0050900,GO:0050919,GO:0051611,GO:0060055,GO:0070051,GO:0070062,GO:0070527,GO:0071062,GO:0098978,GO:0099149,GO:1905598" virus receptor activity|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|fibronectin binding|protease binding|platelet degranulation|protein disulfide isomerase activity|platelet-derived growth factor receptor binding|integrin binding|protein binding|nucleus|nucleoplasm|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|blood coagulation|integrin complex|cell surface|positive regulation of endothelial cell migration|negative regulation of macrophage derived foam cell differentiation|negative regulation of lipid storage|smooth muscle cell migration|coreceptor activity|cell migration|fibroblast growth factor binding|protein phosphopantetheinylation|enzyme binding|C-X3-C chemokine binding|platelet activation|extracellular matrix organization|positive regulation of vascular endothelial growth factor receptor signaling pathway|platelet alpha granule membrane|lamellipodium membrane|filopodium membrane|microvillus membrane|cell-substrate adhesion|insulin-like growth factor I binding|activation of protein kinase activity|negative regulation of lipid transport|ruffle membrane|regulation of protein localization|protein-containing complex|cell adhesion mediated by integrin|heterotypic cell-cell adhesion|substrate adhesion-dependent cell spreading|integrin alphav-beta3 complex|tube development|alphav-beta3 integrin-PKCalpha complex|alphav-beta3 integrin-IGF-1-IGF1R complex|alphav-beta3 integrin-HMGB1 complex|apolipoprotein A-I-mediated signaling pathway|neuregulin binding|wound healing|melanosome|identical protein binding|vascular endothelial growth factor receptor 2 binding|receptor complex|apoptotic cell clearance|regulation of bone resorption|synapse|postsynaptic membrane|viral entry into host cell|vascular endothelial growth factor receptor signaling pathway|mesodermal cell differentiation|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of lipoprotein metabolic process|cell adhesion molecule binding|extracellular matrix binding|leukocyte migration|negative chemotaxis|regulation of serotonin uptake|angiogenesis involved in wound healing|fibrinogen binding|extracellular exosome|platelet aggregation|alphav-beta3 integrin-vitronectin complex|glutamatergic synapse|regulation of postsynaptic neurotransmitter receptor internalization|negative regulation of low-density lipoprotein receptor activity "hsa04015,hsa04145,hsa04151,hsa04380,hsa04510,hsa04512,hsa04611,hsa04640,hsa04810,hsa04919,hsa05163,hsa05165,hsa05168,hsa05205,hsa05206,hsa05410,hsa05412,hsa05414,hsa05418" Rap1 signaling pathway|Phagosome|PI3K-Akt signaling pathway|Osteoclast differentiation|Focal adhesion|ECM-receptor interaction|Platelet activation|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Thyroid hormone signaling pathway|Human cytomegalovirus infection|Human papillomavirus infection|Herpes simplex virus 1 infection|Proteoglycans in cancer|MicroRNAs in cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Fluid shear stress and atherosclerosis ITGB3BP 543.1242707 519.1665274 567.082014 1.092293097 0.127360029 0.639238911 1 7.545469331 8.103947629 23421 integrin subunit beta 3 binding protein "GO:0000777,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006915,GO:0007049,GO:0007155,GO:0007165,GO:0008022,GO:0016020,GO:0034080,GO:0043065,GO:0051301" "condensed chromosome kinetochore|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|apoptotic process|cell cycle|cell adhesion|signal transduction|protein C-terminus binding|membrane|CENP-A containing nucleosome assembly|positive regulation of apoptotic process|cell division" ITGB4 186.1805935 207.0423626 165.3188244 0.798478255 -0.324674976 0.387961564 1 1.610475203 1.264411142 3691 integrin subunit beta 4 "GO:0001664,GO:0005178,GO:0005515,GO:0005604,GO:0005730,GO:0005886,GO:0005925,GO:0006914,GO:0007155,GO:0007160,GO:0007229,GO:0008305,GO:0009611,GO:0009925,GO:0009986,GO:0016477,GO:0030054,GO:0030056,GO:0030198,GO:0031252,GO:0031581,GO:0031965,GO:0031994,GO:0032290,GO:0033627,GO:0035878,GO:0038132,GO:0043235,GO:0043589,GO:0046847,GO:0048333,GO:0048870,GO:0061450,GO:0070062" G protein-coupled receptor binding|integrin binding|protein binding|basement membrane|nucleolus|plasma membrane|focal adhesion|autophagy|cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|integrin complex|response to wounding|basal plasma membrane|cell surface|cell migration|cell junction|hemidesmosome|extracellular matrix organization|cell leading edge|hemidesmosome assembly|nuclear membrane|insulin-like growth factor I binding|peripheral nervous system myelin formation|cell adhesion mediated by integrin|nail development|neuregulin binding|receptor complex|skin morphogenesis|filopodium assembly|mesodermal cell differentiation|cell motility|trophoblast cell migration|extracellular exosome "hsa04151,hsa04510,hsa04512,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGB5 2545.05077 2609.358018 2480.743522 0.950710292 -0.072922317 0.758912418 1 31.16058215 29.12895714 3693 integrin subunit beta 5 "GO:0001618,GO:0002479,GO:0005178,GO:0005515,GO:0005886,GO:0005925,GO:0006936,GO:0007160,GO:0007179,GO:0007229,GO:0008305,GO:0009986,GO:0016477,GO:0030198,GO:0033627,GO:0034684,GO:0035987,GO:0038023,GO:0043149,GO:0043235,GO:0045335,GO:0046718,GO:0070062,GO:0090136" "virus receptor activity|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|integrin binding|protein binding|plasma membrane|focal adhesion|muscle contraction|cell-matrix adhesion|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|integrin complex|cell surface|cell migration|extracellular matrix organization|cell adhesion mediated by integrin|integrin alphav-beta5 complex|endodermal cell differentiation|signaling receptor activity|stress fiber assembly|receptor complex|phagocytic vesicle|viral entry into host cell|extracellular exosome|epithelial cell-cell adhesion" "hsa04145,hsa04151,hsa04510,hsa04512,hsa04810,hsa05165,hsa05205,hsa05410,hsa05412,hsa05414" Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|Human papillomavirus infection|Proteoglycans in cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGB6 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.035892034 0.021735304 3694 integrin subunit beta 6 "GO:0000902,GO:0001618,GO:0005178,GO:0005515,GO:0005654,GO:0005813,GO:0005886,GO:0005925,GO:0006954,GO:0006955,GO:0007155,GO:0007160,GO:0007179,GO:0007229,GO:0008305,GO:0009615,GO:0009897,GO:0009986,GO:0016477,GO:0030054,GO:0030198,GO:0033627,GO:0034685,GO:0038023,GO:0043129,GO:0043235,GO:0043588,GO:0046718,GO:0048286,GO:0055091,GO:0060022,GO:0060348,GO:0060395,GO:0060435,GO:0061520,GO:0070166,GO:0071479,GO:0071604,GO:1901388" cell morphogenesis|virus receptor activity|integrin binding|protein binding|nucleoplasm|centrosome|plasma membrane|focal adhesion|inflammatory response|immune response|cell adhesion|cell-matrix adhesion|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|integrin complex|response to virus|external side of plasma membrane|cell surface|cell migration|cell junction|extracellular matrix organization|cell adhesion mediated by integrin|integrin alphav-beta6 complex|signaling receptor activity|surfactant homeostasis|receptor complex|skin development|viral entry into host cell|lung alveolus development|phospholipid homeostasis|hard palate development|bone development|SMAD protein signal transduction|bronchiole development|Langerhans cell differentiation|enamel mineralization|cellular response to ionizing radiation|transforming growth factor beta production|regulation of transforming growth factor beta activation "hsa04151,hsa04510,hsa04512,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGB8 753.2299675 685.6327487 820.8271864 1.197182002 0.259642495 0.306561788 1 3.567761277 4.199785842 3696 integrin subunit beta 8 "GO:0001570,GO:0001573,GO:0005178,GO:0005886,GO:0005925,GO:0006955,GO:0007155,GO:0007160,GO:0007179,GO:0007229,GO:0008305,GO:0009615,GO:0009986,GO:0010628,GO:0010629,GO:0016477,GO:0030198,GO:0033627,GO:0034686,GO:0038023,GO:0045766,GO:0051216,GO:0060022,GO:0060674,GO:0061520,GO:0070062,GO:1901388,GO:1990430" vasculogenesis|ganglioside metabolic process|integrin binding|plasma membrane|focal adhesion|immune response|cell adhesion|cell-matrix adhesion|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|integrin complex|response to virus|cell surface|positive regulation of gene expression|negative regulation of gene expression|cell migration|extracellular matrix organization|cell adhesion mediated by integrin|integrin alphav-beta8 complex|signaling receptor activity|positive regulation of angiogenesis|cartilage development|hard palate development|placenta blood vessel development|Langerhans cell differentiation|extracellular exosome|regulation of transforming growth factor beta activation|extracellular matrix protein binding "hsa04151,hsa04510,hsa04512,hsa04514,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Cell adhesion molecules|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy ITGBL1 94.361246 80.11186896 108.610623 1.355736977 0.439077312 0.362728175 1 0.720253236 0.960133975 9358 integrin subunit beta like 1 "GO:0005178,GO:0005576,GO:0005886,GO:0005925,GO:0007155,GO:0007160,GO:0007229,GO:0008305,GO:0009986,GO:0016477,GO:0033627" integrin binding|extracellular region|plasma membrane|focal adhesion|cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|integrin complex|cell surface|cell migration|cell adhesion mediated by integrin ITIH4 3.522561699 4.161655531 2.883467868 0.692865579 -0.529352609 0.940314863 1 0.067672123 0.046103083 3700 inter-alpha-trypsin inhibitor heavy chain 4 "GO:0002576,GO:0004866,GO:0004867,GO:0005515,GO:0005576,GO:0006953,GO:0010951,GO:0030212,GO:0031089,GO:0034097,GO:0062023,GO:0070062,GO:0072562" platelet degranulation|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|acute-phase response|negative regulation of endopeptidase activity|hyaluronan metabolic process|platelet dense granule lumen|response to cytokine|collagen-containing extracellular matrix|extracellular exosome|blood microparticle ITM2A 5.325986721 1.040413883 9.61155956 9.238207717 3.207612985 0.087285241 1 0.034359515 0.31210874 9452 integral membrane protein 2A "GO:0001540,GO:0002317,GO:0005515,GO:0005794,GO:0005886,GO:0016021,GO:0042985" amyloid-beta binding|plasma cell differentiation|protein binding|Golgi apparatus|plasma membrane|integral component of membrane|negative regulation of amyloid precursor protein biosynthetic process ITM2B 5418.302929 5003.350362 5833.255497 1.165869882 0.221406784 0.358160537 1 26.46641025 30.34005069 9445 integral membrane protein 2B "GO:0000139,GO:0001540,GO:0005515,GO:0005524,GO:0005576,GO:0005615,GO:0005794,GO:0005886,GO:0007399,GO:0010008,GO:0016020,GO:0030660,GO:0031301,GO:0042985,GO:0043231,GO:0044267,GO:0070062" Golgi membrane|amyloid-beta binding|protein binding|ATP binding|extracellular region|extracellular space|Golgi apparatus|plasma membrane|nervous system development|endosome membrane|membrane|Golgi-associated vesicle membrane|integral component of organelle membrane|negative regulation of amyloid precursor protein biosynthetic process|intracellular membrane-bounded organelle|cellular protein metabolic process|extracellular exosome ITM2C 6090.575572 5241.605141 6939.546002 1.323935286 0.404832605 0.095143326 1 105.8398913 137.7803619 81618 integral membrane protein 2C "GO:0001540,GO:0005515,GO:0005524,GO:0005764,GO:0005765,GO:0005794,GO:0005886,GO:0010977,GO:0016021,GO:0030182,GO:0042985,GO:0048471,GO:0070062,GO:2001238" amyloid-beta binding|protein binding|ATP binding|lysosome|lysosomal membrane|Golgi apparatus|plasma membrane|negative regulation of neuron projection development|integral component of membrane|neuron differentiation|negative regulation of amyloid precursor protein biosynthetic process|perinuclear region of cytoplasm|extracellular exosome|positive regulation of extrinsic apoptotic signaling pathway ITPA 655.6380395 672.1073682 639.1687107 0.950991971 -0.072494934 0.784330929 1 12.04470616 11.26274467 3704 inosine triphosphatase "GO:0000166,GO:0005654,GO:0005737,GO:0005829,GO:0006193,GO:0006195,GO:0009143,GO:0009204,GO:0035529,GO:0035870,GO:0036218,GO:0042802,GO:0043231,GO:0046872,GO:0047429,GO:0051276" nucleotide binding|nucleoplasm|cytoplasm|cytosol|ITP catabolic process|purine nucleotide catabolic process|nucleoside triphosphate catabolic process|deoxyribonucleoside triphosphate catabolic process|NADH pyrophosphatase activity|dITP diphosphatase activity|dTTP diphosphatase activity|identical protein binding|intracellular membrane-bounded organelle|metal ion binding|nucleoside-triphosphate diphosphatase activity|chromosome organization "hsa00230,hsa00983" Purine metabolism|Drug metabolism - other enzymes ITPK1 939.9949347 933.2512527 946.7386167 1.014452018 0.02070063 0.93786913 1 7.615581669 7.596364033 3705 inositol-tetrakisphosphate 1-kinase "GO:0000287,GO:0000825,GO:0003824,GO:0005524,GO:0005737,GO:0005829,GO:0007165,GO:0007596,GO:0016324,GO:0016787,GO:0016853,GO:0021915,GO:0032957,GO:0043647,GO:0047325,GO:0052725,GO:0052726,GO:0052746,GO:0070266" "magnesium ion binding|inositol tetrakisphosphate 6-kinase activity|catalytic activity|ATP binding|cytoplasm|cytosol|signal transduction|blood coagulation|apical plasma membrane|hydrolase activity|isomerase activity|neural tube development|inositol trisphosphate metabolic process|inositol phosphate metabolic process|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 6-kinase activity|inositol-1,3,4-trisphosphate 5-kinase activity|inositol phosphorylation|necroptotic process" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system ITPKA 112.5238296 127.9709076 97.07675156 0.758584536 -0.398618133 0.3787581 1 3.397797083 2.534385079 3706 inositol-trisphosphate 3-kinase A "GO:0000828,GO:0004683,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006020,GO:0006468,GO:0007165,GO:0008440,GO:0016301,GO:0030036,GO:0031267,GO:0032958,GO:0043197,GO:0043647,GO:0046854,GO:0048167,GO:0061003,GO:0097062" "inositol hexakisphosphate kinase activity|calmodulin-dependent protein kinase activity|calmodulin binding|ATP binding|nucleus|cytoplasm|cytosol|inositol metabolic process|protein phosphorylation|signal transduction|inositol-1,4,5-trisphosphate 3-kinase activity|kinase activity|actin cytoskeleton organization|small GTPase binding|inositol phosphate biosynthetic process|dendritic spine|inositol phosphate metabolic process|phosphatidylinositol phosphorylation|regulation of synaptic plasticity|positive regulation of dendritic spine morphogenesis|dendritic spine maintenance" "hsa00562,hsa04020,hsa04070" Inositol phosphate metabolism|Calcium signaling pathway|Phosphatidylinositol signaling system ITPKB 282.1521502 266.345954 297.9583464 1.118689216 0.161809295 0.621837904 1 0.967557963 1.064284217 3707 inositol-trisphosphate 3-kinase B "GO:0000165,GO:0000828,GO:0001932,GO:0002262,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0007165,GO:0007166,GO:0008440,GO:0016020,GO:0016301,GO:0032957,GO:0032958,GO:0033030,GO:0035726,GO:0043647,GO:0045059,GO:0045638,GO:0046579,GO:0046638,GO:0046854,GO:0071277" "MAPK cascade|inositol hexakisphosphate kinase activity|regulation of protein phosphorylation|myeloid cell homeostasis|protein binding|calmodulin binding|ATP binding|nucleus|cytoplasm|cytosol|signal transduction|cell surface receptor signaling pathway|inositol-1,4,5-trisphosphate 3-kinase activity|membrane|kinase activity|inositol trisphosphate metabolic process|inositol phosphate biosynthetic process|negative regulation of neutrophil apoptotic process|common myeloid progenitor cell proliferation|inositol phosphate metabolic process|positive thymic T cell selection|negative regulation of myeloid cell differentiation|positive regulation of Ras protein signal transduction|positive regulation of alpha-beta T cell differentiation|phosphatidylinositol phosphorylation|cellular response to calcium ion" "hsa00562,hsa04020,hsa04070" Inositol phosphate metabolism|Calcium signaling pathway|Phosphatidylinositol signaling system ITPKC 257.2514141 243.4568485 271.0459796 1.113322469 0.154871523 0.648077876 1 3.782487497 4.140660788 80271 inositol-trisphosphate 3-kinase C "GO:0000828,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0008440,GO:0016301,GO:0016607,GO:0032958,GO:0043647,GO:0046854" "inositol hexakisphosphate kinase activity|calmodulin binding|ATP binding|nucleus|cytoplasm|cytosol|inositol-1,4,5-trisphosphate 3-kinase activity|kinase activity|nuclear speck|inositol phosphate biosynthetic process|inositol phosphate metabolic process|phosphatidylinositol phosphorylation" "hsa00562,hsa04020,hsa04070" Inositol phosphate metabolism|Calcium signaling pathway|Phosphatidylinositol signaling system ITPR1 273.9471116 353.7407201 194.1535031 0.548858223 -0.865494563 0.007843458 0.544463388 1.581510604 0.853499876 3708 "inositol 1,4,5-trisphosphate receptor type 1" "GO:0001666,GO:0005220,GO:0005509,GO:0005515,GO:0005637,GO:0005730,GO:0005783,GO:0005789,GO:0005886,GO:0005955,GO:0006816,GO:0007165,GO:0009791,GO:0010506,GO:0014069,GO:0015085,GO:0015278,GO:0016020,GO:0016021,GO:0016529,GO:0019855,GO:0030168,GO:0030658,GO:0030659,GO:0030667,GO:0031088,GO:0031094,GO:0031095,GO:0032469,GO:0035091,GO:0042045,GO:0048016,GO:0048471,GO:0050796,GO:0050849,GO:0050882,GO:0051209,GO:0070059,GO:0070679,GO:0098685,GO:0098695,GO:0099566,GO:1903779" "response to hypoxia|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|calcium ion binding|protein binding|nuclear inner membrane|nucleolus|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|calcineurin complex|calcium ion transport|signal transduction|post-embryonic development|regulation of autophagy|postsynaptic density|calcium ion transmembrane transporter activity|calcium-release channel activity|membrane|integral component of membrane|sarcoplasmic reticulum|calcium channel inhibitor activity|platelet activation|transport vesicle membrane|cytoplasmic vesicle membrane|secretory granule membrane|platelet dense granule membrane|platelet dense tubular network|platelet dense tubular network membrane|endoplasmic reticulum calcium ion homeostasis|phosphatidylinositol binding|epithelial fluid transport|inositol phosphate-mediated signaling|perinuclear region of cytoplasm|regulation of insulin secretion|negative regulation of calcium-mediated signaling|voluntary musculoskeletal movement|release of sequestered calcium ion into cytosol|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|inositol 1,4,5 trisphosphate binding|Schaffer collateral - CA1 synapse|inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels|regulation of postsynaptic cytosolic calcium ion concentration|regulation of cardiac conduction" "hsa04020,hsa04022,hsa04070,hsa04114,hsa04140,hsa04210,hsa04218,hsa04270,hsa04371,hsa04540,hsa04611,hsa04621,hsa04625,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04750,hsa04912,hsa04915,hsa04918,hsa04921,hsa04922,hsa04924,hsa04925,hsa04927,hsa04928,hsa04929,hsa04934,hsa04935,hsa04970,hsa04971,hsa04972,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05131,hsa05163,hsa05167,hsa05170,hsa05205" "Calcium signaling pathway|cGMP-PKG signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Autophagy - animal|Apoptosis|Cellular senescence|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Estrogen signaling pathway|Thyroid hormone synthesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Cushing syndrome|Growth hormone synthesis, secretion and action|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Shigellosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Proteoglycans in cancer" ITPR2 1222.13641 1325.487286 1118.785533 0.844056027 -0.244589329 0.312005327 1 5.322309859 4.417154693 3709 "inositol 1,4,5-trisphosphate receptor type 2" "GO:0001666,GO:0005220,GO:0005509,GO:0005654,GO:0005783,GO:0005789,GO:0005886,GO:0005938,GO:0007165,GO:0015085,GO:0016020,GO:0016021,GO:0016529,GO:0030168,GO:0030659,GO:0030667,GO:0031095,GO:0033017,GO:0035091,GO:0043235,GO:0044325,GO:0048016,GO:0050796,GO:0051209,GO:0070679,GO:0071320,GO:0071361,GO:0097110,GO:1903779" "response to hypoxia|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|calcium ion binding|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|cell cortex|signal transduction|calcium ion transmembrane transporter activity|membrane|integral component of membrane|sarcoplasmic reticulum|platelet activation|cytoplasmic vesicle membrane|secretory granule membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane|phosphatidylinositol binding|receptor complex|ion channel binding|inositol phosphate-mediated signaling|regulation of insulin secretion|release of sequestered calcium ion into cytosol|inositol 1,4,5 trisphosphate binding|cellular response to cAMP|cellular response to ethanol|scaffold protein binding|regulation of cardiac conduction" "hsa04020,hsa04022,hsa04070,hsa04114,hsa04210,hsa04218,hsa04270,hsa04371,hsa04540,hsa04611,hsa04621,hsa04625,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04750,hsa04912,hsa04915,hsa04918,hsa04921,hsa04922,hsa04924,hsa04925,hsa04927,hsa04928,hsa04929,hsa04934,hsa04935,hsa04970,hsa04971,hsa04972,hsa05010,hsa05012,hsa05017,hsa05020,hsa05022,hsa05131,hsa05163,hsa05167,hsa05170,hsa05205" "Calcium signaling pathway|cGMP-PKG signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Apoptosis|Cellular senescence|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Estrogen signaling pathway|Thyroid hormone synthesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Cushing syndrome|Growth hormone synthesis, secretion and action|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Alzheimer disease|Parkinson disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Shigellosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Proteoglycans in cancer" ITPR3 6932.547306 7828.074053 6037.02056 0.771201258 -0.374820689 0.125139532 1 45.89365317 34.80098508 3710 "inositol 1,4,5-trisphosphate receptor type 3" "GO:0000822,GO:0005220,GO:0005509,GO:0005515,GO:0005640,GO:0005654,GO:0005730,GO:0005737,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0005903,GO:0007186,GO:0007204,GO:0007613,GO:0015278,GO:0016020,GO:0016529,GO:0030168,GO:0030659,GO:0030667,GO:0031095,GO:0035091,GO:0043025,GO:0043209,GO:0043235,GO:0043533,GO:0045177,GO:0048016,GO:0050796,GO:0050913,GO:0050916,GO:0050917,GO:0051209,GO:0051592,GO:0060291,GO:0060402,GO:0070679,GO:1903779" "inositol hexakisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|calcium ion binding|protein binding|nuclear outer membrane|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|brush border|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|memory|calcium-release channel activity|membrane|sarcoplasmic reticulum|platelet activation|cytoplasmic vesicle membrane|secretory granule membrane|platelet dense tubular network membrane|phosphatidylinositol binding|neuronal cell body|myelin sheath|receptor complex|inositol 1,3,4,5 tetrakisphosphate binding|apical part of cell|inositol phosphate-mediated signaling|regulation of insulin secretion|sensory perception of bitter taste|sensory perception of sweet taste|sensory perception of umami taste|release of sequestered calcium ion into cytosol|response to calcium ion|long-term synaptic potentiation|calcium ion transport into cytosol|inositol 1,4,5 trisphosphate binding|regulation of cardiac conduction" "hsa04020,hsa04022,hsa04070,hsa04114,hsa04210,hsa04218,hsa04270,hsa04371,hsa04540,hsa04611,hsa04621,hsa04625,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04742,hsa04750,hsa04911,hsa04912,hsa04915,hsa04918,hsa04921,hsa04922,hsa04924,hsa04925,hsa04927,hsa04928,hsa04929,hsa04934,hsa04935,hsa04970,hsa04971,hsa04972,hsa05010,hsa05012,hsa05014,hsa05017,hsa05020,hsa05022,hsa05131,hsa05163,hsa05167,hsa05170,hsa05205" "Calcium signaling pathway|cGMP-PKG signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Apoptosis|Cellular senescence|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Thyroid hormone synthesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Cushing syndrome|Growth hormone synthesis, secretion and action|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Shigellosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Proteoglycans in cancer" ITPRID2 4763.486423 4478.981765 5047.991081 1.127039882 0.172538569 0.471558362 1 33.58176802 37.21465699 6744 ITPR interacting domain containing 2 "GO:0005102,GO:0005654,GO:0005829,GO:0005886,GO:0051015" signaling receptor binding|nucleoplasm|cytosol|plasma membrane|actin filament binding ITPRIP 2434.750578 2628.085468 2241.415689 0.852870166 -0.22960196 0.331484335 1 19.59705061 16.43405801 85450 "inositol 1,4,5-trisphosphate receptor interacting protein" "GO:0004860,GO:0005515,GO:0005640,GO:0005886,GO:0006469,GO:0016020,GO:0016021,GO:1902042" protein kinase inhibitor activity|protein binding|nuclear outer membrane|plasma membrane|negative regulation of protein kinase activity|membrane|integral component of membrane|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ITPRIPL2 874.2098575 997.7569135 750.6628016 0.752350389 -0.410523377 0.0992118 1 6.946054353 5.13841889 162073 ITPRIP like 2 GO:0016021 integral component of membrane ITSN1 1284.453031 1321.325631 1247.580431 0.944188474 -0.082853224 0.733186349 1 3.593208684 3.335894549 6453 intersectin 1 "GO:0005085,GO:0005509,GO:0005515,GO:0005635,GO:0005737,GO:0005829,GO:0005886,GO:0005905,GO:0006887,GO:0006897,GO:0007186,GO:0007420,GO:0015031,GO:0016032,GO:0016197,GO:0030027,GO:0034613,GO:0035556,GO:0042734,GO:0043025,GO:0043065,GO:0043197,GO:0048013,GO:0050790,GO:0051056,GO:0055037,GO:0060090,GO:0060124,GO:0060999,GO:0061024,GO:0070064,GO:0097440,GO:0097708,GO:0098793,GO:0098871,GO:0098978,GO:0150007,GO:1905274,GO:2001288" guanyl-nucleotide exchange factor activity|calcium ion binding|protein binding|nuclear envelope|cytoplasm|cytosol|plasma membrane|clathrin-coated pit|exocytosis|endocytosis|G protein-coupled receptor signaling pathway|brain development|protein transport|viral process|endosomal transport|lamellipodium|cellular protein localization|intracellular signal transduction|presynaptic membrane|neuronal cell body|positive regulation of apoptotic process|dendritic spine|ephrin receptor signaling pathway|regulation of catalytic activity|regulation of small GTPase mediated signal transduction|recycling endosome|molecular adaptor activity|positive regulation of growth hormone secretion|positive regulation of dendritic spine development|membrane organization|proline-rich region binding|apical dendrite|intracellular vesicle|presynapse|postsynaptic actin cytoskeleton|glutamatergic synapse|clathrin-dependent synaptic vesicle endocytosis|regulation of modification of postsynaptic actin cytoskeleton|positive regulation of caveolin-mediated endocytosis ITSN2 1103.731788 1181.910171 1025.553405 0.867708419 -0.204717769 0.401715749 1 5.513669017 4.704198961 50618 intersectin 2 "GO:0005085,GO:0005509,GO:0005515,GO:0005737,GO:0005813,GO:0005886,GO:0005905,GO:0006897,GO:0016032,GO:0016197,GO:0030154,GO:0042734,GO:0050790,GO:0060090,GO:0070062,GO:0097708,GO:0098793,GO:0150007,GO:1903861" guanyl-nucleotide exchange factor activity|calcium ion binding|protein binding|cytoplasm|centrosome|plasma membrane|clathrin-coated pit|endocytosis|viral process|endosomal transport|cell differentiation|presynaptic membrane|regulation of catalytic activity|molecular adaptor activity|extracellular exosome|intracellular vesicle|presynapse|clathrin-dependent synaptic vesicle endocytosis|positive regulation of dendrite extension IVD 821.2776973 869.7860059 772.7693886 0.888459211 -0.170622551 0.498110534 1 8.253712755 7.210377841 3712 isovaleryl-CoA dehydrogenase "GO:0004085,GO:0005515,GO:0005759,GO:0006552,GO:0008470,GO:0009083,GO:0031966,GO:0033539,GO:0042802,GO:0050660" butyryl-CoA dehydrogenase activity|protein binding|mitochondrial matrix|leucine catabolic process|isovaleryl-CoA dehydrogenase activity|branched-chain amino acid catabolic process|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|identical protein binding|flavin adenine dinucleotide binding hsa00280 "Valine, leucine and isoleucine degradation" IVNS1ABP 2563.616517 2352.375789 2774.857245 1.179597774 0.238295006 0.313610687 1 15.13283177 17.55194814 10625 influenza virus NS1A binding protein "GO:0005515,GO:0005654,GO:0005667,GO:0005681,GO:0005829,GO:0005856,GO:0006383,GO:0008380,GO:0009615,GO:0016032,GO:0031397,GO:2001243" protein binding|nucleoplasm|transcription regulator complex|spliceosomal complex|cytosol|cytoskeleton|transcription by RNA polymerase III|RNA splicing|response to virus|viral process|negative regulation of protein ubiquitination|negative regulation of intrinsic apoptotic signaling pathway IWS1 1868.857318 1864.421678 1873.292958 1.004758194 0.006848343 0.979476797 1 24.56202377 24.26592677 55677 "interacts with SUPT6H, CTD assembly factor 1" "GO:0005515,GO:0005634,GO:0005654,GO:0006366,GO:0006368,GO:0006397,GO:0008380,GO:0010793,GO:0016973,GO:0050684,GO:0051028,GO:0090239,GO:2001253" protein binding|nucleus|nucleoplasm|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|mRNA processing|RNA splicing|regulation of mRNA export from nucleus|poly(A)+ mRNA export from nucleus|regulation of mRNA processing|mRNA transport|regulation of histone H4 acetylation|regulation of histone H3-K36 trimethylation IZUMO4 12.56925494 14.56579436 10.57271552 0.725859178 -0.462238413 0.707585678 1 0.63665002 0.454385337 113177 IZUMO family member 4 "GO:0005576,GO:0005634" extracellular region|nucleus JADE1 545.9624648 631.5312268 460.3937029 0.729011779 -0.45598597 0.088660856 1 5.101977122 3.657162271 79960 jade family PHD finger 1 "GO:0000123,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005886,GO:0006915,GO:0016607,GO:0030308,GO:0036064,GO:0043966,GO:0043981,GO:0043982,GO:0043983,GO:0043984,GO:0045893,GO:0046872,GO:0090090,GO:2000134" "histone acetyltransferase complex|transcription coactivator activity|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|plasma membrane|apoptotic process|nuclear speck|negative regulation of cell growth|ciliary basal body|histone H3 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K12 acetylation|histone H4-K16 acetylation|positive regulation of transcription, DNA-templated|metal ion binding|negative regulation of canonical Wnt signaling pathway|negative regulation of G1/S transition of mitotic cell cycle" JADE2 1090.662448 1116.364096 1064.960799 0.95395472 -0.068007305 0.78350113 1 8.452021566 7.927925064 23338 jade family PHD finger 2 "GO:0000123,GO:0005515,GO:0005654,GO:0016567,GO:0016740,GO:0043966,GO:0043981,GO:0043982,GO:0043983,GO:0043984,GO:0046872,GO:0070062" histone acetyltransferase complex|protein binding|nucleoplasm|protein ubiquitination|transferase activity|histone H3 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K12 acetylation|histone H4-K16 acetylation|metal ion binding|extracellular exosome JADE3 571.2896731 589.9146715 552.6646747 0.93685528 -0.094101889 0.72791157 1 6.312946019 5.815348728 9767 jade family PHD finger 3 "GO:0000123,GO:0005515,GO:0043966,GO:0043981,GO:0043982,GO:0043983,GO:0043984,GO:0046872" histone acetyltransferase complex|protein binding|histone H3 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K12 acetylation|histone H4-K16 acetylation|metal ion binding JAG1 558.0360505 683.5519209 432.5201802 0.632753953 -0.660283479 0.013364819 0.686929575 6.14139894 3.820967603 182 jagged canonical Notch ligand 1 "GO:0001525,GO:0001709,GO:0001953,GO:0001974,GO:0002011,GO:0002456,GO:0003180,GO:0003184,GO:0003215,GO:0005112,GO:0005198,GO:0005509,GO:0005515,GO:0005543,GO:0005576,GO:0005886,GO:0005887,GO:0005912,GO:0007219,GO:0007399,GO:0008083,GO:0016020,GO:0016324,GO:0022408,GO:0030097,GO:0030216,GO:0030336,GO:0032495,GO:0035909,GO:0042127,GO:0042491,GO:0045445,GO:0045446,GO:0045599,GO:0045602,GO:0045639,GO:0045665,GO:0045669,GO:0045747,GO:0045944,GO:0060411,GO:0061073,GO:0061156,GO:0061309,GO:0061314,GO:0061444,GO:0062043,GO:0072006,GO:0072015,GO:0072017,GO:0072070,GO:0097150,GO:2000737" angiogenesis|cell fate determination|negative regulation of cell-matrix adhesion|blood vessel remodeling|morphogenesis of an epithelial sheet|T cell mediated immunity|aortic valve morphogenesis|pulmonary valve morphogenesis|cardiac right ventricle morphogenesis|Notch binding|structural molecule activity|calcium ion binding|protein binding|phospholipid binding|extracellular region|plasma membrane|integral component of plasma membrane|adherens junction|Notch signaling pathway|nervous system development|growth factor activity|membrane|apical plasma membrane|negative regulation of cell-cell adhesion|hemopoiesis|keratinocyte differentiation|negative regulation of cell migration|response to muramyl dipeptide|aorta morphogenesis|regulation of cell population proliferation|inner ear auditory receptor cell differentiation|myoblast differentiation|endothelial cell differentiation|negative regulation of fat cell differentiation|negative regulation of endothelial cell differentiation|positive regulation of myeloid cell differentiation|negative regulation of neuron differentiation|positive regulation of osteoblast differentiation|positive regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|cardiac septum morphogenesis|ciliary body morphogenesis|pulmonary artery morphogenesis|cardiac neural crest cell development involved in outflow tract morphogenesis|Notch signaling involved in heart development|endocardial cushion cell development|positive regulation of cardiac epithelial to mesenchymal transition|nephron development|glomerular visceral epithelial cell development|distal tubule development|loop of Henle development|neuronal stem cell population maintenance|negative regulation of stem cell differentiation "hsa01522,hsa04330,hsa04371,hsa04658,hsa04668,hsa05165,hsa05200,hsa05224" Endocrine resistance|Notch signaling pathway|Apelin signaling pathway|Th1 and Th2 cell differentiation|TNF signaling pathway|Human papillomavirus infection|Pathways in cancer|Breast cancer JAG2 54.08704502 44.73779695 63.4362931 1.417957464 0.503814255 0.395386196 1 0.413575957 0.576619951 3714 jagged canonical Notch ligand 2 "GO:0001501,GO:0001701,GO:0003016,GO:0005112,GO:0005509,GO:0005515,GO:0005886,GO:0005887,GO:0007219,GO:0007283,GO:0008083,GO:0009912,GO:0016331,GO:0030154,GO:0030155,GO:0030217,GO:0042127,GO:0042475,GO:0042492,GO:0045061,GO:0045747,GO:1990134" skeletal system development|in utero embryonic development|respiratory system process|Notch binding|calcium ion binding|protein binding|plasma membrane|integral component of plasma membrane|Notch signaling pathway|spermatogenesis|growth factor activity|auditory receptor cell fate commitment|morphogenesis of embryonic epithelium|cell differentiation|regulation of cell adhesion|T cell differentiation|regulation of cell population proliferation|odontogenesis of dentin-containing tooth|gamma-delta T cell differentiation|thymic T cell selection|positive regulation of Notch signaling pathway|epithelial cell apoptotic process involved in palatal shelf morphogenesis "hsa01522,hsa04330,hsa04658,hsa05200,hsa05224" Endocrine resistance|Notch signaling pathway|Th1 and Th2 cell differentiation|Pathways in cancer|Breast cancer JAGN1 490.3449815 508.7623886 471.9275744 0.92759918 -0.108426551 0.698078966 1 15.57757522 14.20794907 84522 jagunal homolog 1 "GO:0002446,GO:0005515,GO:0005783,GO:0005789,GO:0006887,GO:0007029,GO:0015031,GO:0016021,GO:0016192,GO:0030223,GO:0038158,GO:0050832,GO:0061179,GO:1904577,GO:1990266" neutrophil mediated immunity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|exocytosis|endoplasmic reticulum organization|protein transport|integral component of membrane|vesicle-mediated transport|neutrophil differentiation|granulocyte colony-stimulating factor signaling pathway|defense response to fungus|negative regulation of insulin secretion involved in cellular response to glucose stimulus|cellular response to tunicamycin|neutrophil migration JAK1 5490.068908 5600.54793 5379.589886 0.960547067 -0.058071788 0.810191637 1 53.85422517 50.86389458 3716 Janus kinase 1 "GO:0000165,GO:0004713,GO:0004715,GO:0005131,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005768,GO:0005829,GO:0005856,GO:0005925,GO:0006468,GO:0016020,GO:0018108,GO:0019221,GO:0019903,GO:0031625,GO:0031730,GO:0034112,GO:0035556,GO:0035722,GO:0035723,GO:0038110,GO:0038111,GO:0038113,GO:0038114,GO:0046677,GO:0046872,GO:0060333,GO:0060334,GO:0060337,GO:0070102,GO:0070106,GO:0070757,GO:0150105,GO:1903672" MAPK cascade|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|growth hormone receptor binding|protein binding|ATP binding|nucleus|cytoplasm|endosome|cytosol|cytoskeleton|focal adhesion|protein phosphorylation|membrane|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|protein phosphatase binding|ubiquitin protein ligase binding|CCR5 chemokine receptor binding|positive regulation of homotypic cell-cell adhesion|intracellular signal transduction|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|interleukin-2-mediated signaling pathway|interleukin-7-mediated signaling pathway|interleukin-9-mediated signaling pathway|interleukin-21-mediated signaling pathway|response to antibiotic|metal ion binding|interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|interleukin-6-mediated signaling pathway|interleukin-27-mediated signaling pathway|interleukin-35-mediated signaling pathway|protein localization to cell-cell junction|positive regulation of sprouting angiogenesis "hsa01521,hsa04151,hsa04217,hsa04380,hsa04550,hsa04621,hsa04630,hsa04658,hsa04659,hsa05140,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05171,hsa05200,hsa05203,hsa05212,hsa05235" EGFR tyrosine kinase inhibitor resistance|PI3K-Akt signaling pathway|Necroptosis|Osteoclast differentiation|Signaling pathways regulating pluripotency of stem cells|NOD-like receptor signaling pathway|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Leishmaniasis|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Pancreatic cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer JAK2 471.7911387 438.0142446 505.5680329 1.154227378 0.206927456 0.457832449 1 3.146589743 3.571105433 3717 Janus kinase 2 "GO:0000165,GO:0000186,GO:0000791,GO:0001774,GO:0002250,GO:0004672,GO:0004713,GO:0004715,GO:0005102,GO:0005131,GO:0005143,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005901,GO:0005925,GO:0006468,GO:0006915,GO:0006919,GO:0007165,GO:0007167,GO:0007186,GO:0007204,GO:0007259,GO:0007260,GO:0007498,GO:0007596,GO:0008022,GO:0008285,GO:0008631,GO:0010667,GO:0010811,GO:0014068,GO:0018108,GO:0019221,GO:0019901,GO:0020037,GO:0022408,GO:0030041,GO:0030154,GO:0030218,GO:0030335,GO:0031103,GO:0031702,GO:0031904,GO:0031959,GO:0032024,GO:0032496,GO:0032516,GO:0032731,GO:0032760,GO:0033130,GO:0033194,GO:0033209,GO:0034612,GO:0035401,GO:0035409,GO:0035556,GO:0035722,GO:0038155,GO:0042169,GO:0042307,GO:0042393,GO:0042531,GO:0042802,GO:0042976,GO:0042981,GO:0043388,GO:0043392,GO:0043524,GO:0043548,GO:0043560,GO:0045121,GO:0045348,GO:0045428,GO:0045429,GO:0045597,GO:0045822,GO:0046425,GO:0046579,GO:0046677,GO:0046777,GO:0046872,GO:0048008,GO:0050727,GO:0050729,GO:0050731,GO:0050804,GO:0050867,GO:0051091,GO:0051428,GO:0051770,GO:0060333,GO:0060334,GO:0060391,GO:0060396,GO:0060397,GO:0060399,GO:0061180,GO:0070102,GO:0070106,GO:0070671,GO:0070757,GO:0097191,GO:0097296,GO:0098794,GO:0098978,GO:0099527,GO:0120162,GO:1902728,GO:1904037,GO:1904707,GO:2000273" MAPK cascade|activation of MAPKK activity|euchromatin|microglial cell activation|adaptive immune response|protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|growth hormone receptor binding|interleukin-12 receptor binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|cytoskeleton|plasma membrane|caveola|focal adhesion|protein phosphorylation|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|enzyme linked receptor protein signaling pathway|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|receptor signaling pathway via JAK-STAT|tyrosine phosphorylation of STAT protein|mesoderm development|blood coagulation|protein C-terminus binding|negative regulation of cell population proliferation|intrinsic apoptotic signaling pathway in response to oxidative stress|negative regulation of cardiac muscle cell apoptotic process|positive regulation of cell-substrate adhesion|positive regulation of phosphatidylinositol 3-kinase signaling|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|protein kinase binding|heme binding|negative regulation of cell-cell adhesion|actin filament polymerization|cell differentiation|erythrocyte differentiation|positive regulation of cell migration|axon regeneration|type 1 angiotensin receptor binding|endosome lumen|mineralocorticoid receptor signaling pathway|positive regulation of insulin secretion|response to lipopolysaccharide|positive regulation of phosphoprotein phosphatase activity|positive regulation of interleukin-1 beta production|positive regulation of tumor necrosis factor production|acetylcholine receptor binding|response to hydroperoxide|tumor necrosis factor-mediated signaling pathway|response to tumor necrosis factor|histone kinase activity (H3-Y41 specific)|histone H3-Y41 phosphorylation|intracellular signal transduction|interleukin-12-mediated signaling pathway|interleukin-23-mediated signaling pathway|SH2 domain binding|positive regulation of protein import into nucleus|histone binding|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|activation of Janus kinase activity|regulation of apoptotic process|positive regulation of DNA binding|negative regulation of DNA binding|negative regulation of neuron apoptotic process|phosphatidylinositol 3-kinase binding|insulin receptor substrate binding|membrane raft|positive regulation of MHC class II biosynthetic process|regulation of nitric oxide biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of cell differentiation|negative regulation of heart contraction|regulation of receptor signaling pathway via JAK-STAT|positive regulation of Ras protein signal transduction|response to antibiotic|protein autophosphorylation|metal ion binding|platelet-derived growth factor receptor signaling pathway|regulation of inflammatory response|positive regulation of inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|modulation of chemical synaptic transmission|positive regulation of cell activation|positive regulation of DNA-binding transcription factor activity|peptide hormone receptor binding|positive regulation of nitric-oxide synthase biosynthetic process|interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|positive regulation of SMAD protein signal transduction|growth hormone receptor signaling pathway|growth hormone receptor signaling pathway via JAK-STAT|positive regulation of growth hormone receptor signaling pathway|mammary gland epithelium development|interleukin-6-mediated signaling pathway|interleukin-27-mediated signaling pathway|response to interleukin-12|interleukin-35-mediated signaling pathway|extrinsic apoptotic signaling pathway|activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|postsynapse|glutamatergic synapse|postsynapse to nucleus signaling pathway|positive regulation of cold-induced thermogenesis|positive regulation of growth factor dependent skeletal muscle satellite cell proliferation|positive regulation of epithelial cell apoptotic process|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of signaling receptor activity "hsa01521,hsa04062,hsa04151,hsa04217,hsa04550,hsa04630,hsa04658,hsa04659,hsa04725,hsa04917,hsa04920,hsa04933,hsa04935,hsa05140,hsa05145,hsa05152,hsa05161,hsa05164,hsa05167,hsa05168,hsa05200,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Chemokine signaling pathway|PI3K-Akt signaling pathway|Necroptosis|Signaling pathways regulating pluripotency of stem cells|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Cholinergic synapse|Prolactin signaling pathway|Adipocytokine signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Leishmaniasis|Toxoplasmosis|Tuberculosis|Hepatitis B|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Pathways in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" JAKMIP2 66.49778411 55.14193578 77.85363244 1.411877029 0.497614438 0.363523576 1 0.319143668 0.443051574 9832 janus kinase and microtubule interacting protein 2 "GO:0005515,GO:0005794,GO:0008017,GO:0019900" protein binding|Golgi apparatus|microtubule binding|kinase binding JAM2 73.58253647 64.50566072 82.65941222 1.281428812 0.357753334 0.503264033 1 0.669626251 0.843719592 58494 junctional adhesion molecule 2 "GO:0005178,GO:0005515,GO:0005886,GO:0005887,GO:0005923,GO:0007286,GO:0007520,GO:0009986,GO:0030198,GO:0031642,GO:0035633,GO:0036477,GO:0044291,GO:0045123,GO:0050900,GO:0050901,GO:0070160,GO:0071593,GO:0097241,GO:0098609,GO:0098636,GO:2000403" integrin binding|protein binding|plasma membrane|integral component of plasma membrane|bicellular tight junction|spermatid development|myoblast fusion|cell surface|extracellular matrix organization|negative regulation of myelination|maintenance of blood-brain barrier|somatodendritic compartment|cell-cell contact zone|cellular extravasation|leukocyte migration|leukocyte tethering or rolling|tight junction|lymphocyte aggregation|hematopoietic stem cell migration to bone marrow|cell-cell adhesion|protein complex involved in cell adhesion|positive regulation of lymphocyte migration "hsa04514,hsa04530,hsa04670,hsa05120" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Epithelial cell signaling in Helicobacter pylori infection JARID2 508.1313971 496.277422 519.9853722 1.047771567 0.067324218 0.811115704 1 3.672918305 3.783981951 3720 jumonji and AT-rich interaction domain containing 2 "GO:0000122,GO:0001889,GO:0003677,GO:0003682,GO:0005634,GO:0005654,GO:0005739,GO:0006338,GO:0007417,GO:0008134,GO:0010614,GO:0031061,GO:0032452,GO:0034647,GO:0034721,GO:0035097,GO:0035098,GO:0045814,GO:0045892,GO:0048536,GO:0048538,GO:0048863,GO:0051574,GO:0060044,GO:1990830" "negative regulation of transcription by RNA polymerase II|liver development|DNA binding|chromatin binding|nucleus|nucleoplasm|mitochondrion|chromatin remodeling|central nervous system development|transcription factor binding|negative regulation of cardiac muscle hypertrophy|negative regulation of histone methylation|histone demethylase activity|histone demethylase activity (H3-trimethyl-K4 specific)|histone H3-K4 demethylation, trimethyl-H3-K4-specific|histone methyltransferase complex|ESC/E(Z) complex|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|spleen development|thymus development|stem cell differentiation|positive regulation of histone H3-K9 methylation|negative regulation of cardiac muscle cell proliferation|cellular response to leukemia inhibitory factor" hsa04550 Signaling pathways regulating pluripotency of stem cells JAZF1 381.4676309 375.5894116 387.3458503 1.031301305 0.044465892 0.8883541 1 6.188489223 6.275399587 221895 JAZF zinc finger 1 "GO:0000122,GO:0001650,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006629,GO:0017053,GO:0046872" negative regulation of transcription by RNA polymerase II|fibrillar center|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytosol|lipid metabolic process|transcription repressor complex|metal ion binding other JDP2 441.4795132 525.4090107 357.5500156 0.680517479 -0.555295876 0.048572898 1 3.124594745 2.090759897 122953 Jun dimerization protein 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003682,GO:0005515,GO:0005634,GO:0006357,GO:0031065,GO:0044877,GO:0045599,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|chromatin binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of histone deacetylation|protein-containing complex binding|negative regulation of fat cell differentiation|sequence-specific double-stranded DNA binding" JHY 170.3315811 182.0724295 158.5907327 0.871031013 -0.199204007 0.614873506 1 1.246391858 1.067479148 79864 junctional cadherin complex regulator "GO:0005576,GO:0007420,GO:0030154,GO:0035082,GO:0044458,GO:0090175,GO:0090660" extracellular region|brain development|cell differentiation|axoneme assembly|motile cilium assembly|regulation of establishment of planar polarity|cerebrospinal fluid circulation JKAMP 1204.970195 1190.233482 1219.706908 1.024762727 0.035289907 0.887460319 1 25.12680908 25.31814246 51528 JNK1/MAPK8 associated membrane protein "GO:0005789,GO:0006986,GO:0016021,GO:0030433,GO:0031625" endoplasmic reticulum membrane|response to unfolded protein|integral component of membrane|ubiquitin-dependent ERAD pathway|ubiquitin protein ligase binding JMJD1C 3959.3423 4223.03995 3695.644651 0.875114774 -0.192455852 0.41899237 1 18.01853857 15.50442834 221037 jumonji domain containing 1C "GO:0000118,GO:0000785,GO:0003712,GO:0005515,GO:0005654,GO:0006355,GO:0006357,GO:0007596,GO:0031490,GO:0032454,GO:0033169,GO:0046872,GO:0046966,GO:0051213,GO:0055114" "histone deacetylase complex|chromatin|transcription coregulator activity|protein binding|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|blood coagulation|chromatin DNA binding|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|metal ion binding|thyroid hormone receptor binding|dioxygenase activity|oxidation-reduction process" hsa05202 Transcriptional misregulation in cancer chromosome_remodelling_factor JMJD4 199.5128596 216.4060876 182.6196316 0.843874743 -0.24489922 0.506261219 1 4.307793792 3.57440759 65094 jumonji domain containing 4 "GO:0005515,GO:0005737,GO:0016706,GO:0018126,GO:0045905,GO:0046872,GO:0055114" protein binding|cytoplasm|2-oxoglutarate-dependent dioxygenase activity|protein hydroxylation|positive regulation of translational termination|metal ion binding|oxidation-reduction process JMJD6 925.6480212 758.4617204 1092.834322 1.440856265 0.526926425 0.03346285 0.928203799 7.348893977 10.41151238 23210 "jumonji domain containing 6, arginine demethylase and lysine hydroxylase" "GO:0001822,GO:0002040,GO:0003723,GO:0003727,GO:0005506,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006397,GO:0006482,GO:0007166,GO:0007507,GO:0008380,GO:0018215,GO:0018395,GO:0030324,GO:0032451,GO:0032452,GO:0033077,GO:0033746,GO:0033749,GO:0035513,GO:0035515,GO:0038023,GO:0042116,GO:0042802,GO:0043654,GO:0045893,GO:0045944,GO:0048024,GO:0048821,GO:0051260,GO:0060041,GO:0070078,GO:0070079,GO:0070815,GO:0106140,GO:0140537,GO:1990904" "kidney development|sprouting angiogenesis|RNA binding|single-stranded RNA binding|iron ion binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|mRNA processing|protein demethylation|cell surface receptor signaling pathway|heart development|RNA splicing|protein phosphopantetheinylation|peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine|lung development|demethylase activity|histone demethylase activity|T cell differentiation in thymus|histone demethylase activity (H3-R2 specific)|histone demethylase activity (H4-R3 specific)|oxidative RNA demethylation|oxidative RNA demethylase activity|signaling receptor activity|macrophage activation|identical protein binding|recognition of apoptotic cell|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of mRNA splicing, via spliceosome|erythrocyte development|protein homooligomerization|retina development in camera-type eye|histone H3-R2 demethylation|histone H4-R3 demethylation|peptidyl-lysine 5-dioxygenase activity|P-TEFb complex binding|transcription regulator activator activity|ribonucleoprotein complex" other JMJD7 52.88308487 50.98028025 54.78588949 1.074648653 0.10386506 0.891886265 1 1.930960865 2.040380429 100137047 jumonji domain containing 7 "GO:0004175,GO:0004177,GO:0004497,GO:0005515,GO:0005634,GO:0005737,GO:0006508,GO:0016706,GO:0018126,GO:0035064,GO:0046872,GO:0055114" endopeptidase activity|aminopeptidase activity|monooxygenase activity|protein binding|nucleus|cytoplasm|proteolysis|2-oxoglutarate-dependent dioxygenase activity|protein hydroxylation|methylated histone binding|metal ion binding|oxidation-reduction process JMJD8 651.2631479 696.0368875 606.4894082 0.871346647 -0.198681316 0.444989111 1 19.20693352 16.45584455 339123 jumonji domain containing 8 "GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005788,GO:0006110,GO:0043123,GO:1903302,GO:1903672" protein binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|regulation of glycolytic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|regulation of pyruvate kinase activity|positive regulation of sprouting angiogenesis JMY 626.9172173 687.7135764 566.1208581 0.823192791 -0.280697748 0.282383286 1 4.033187869 3.264533947 133746 "junction mediating and regulatory protein, p53 cofactor" "GO:0003713,GO:0003779,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005856,GO:0006281,GO:0006357,GO:0007050,GO:0031252,GO:0034314,GO:0043065,GO:0045893,GO:0051091,GO:0070060,GO:0070358,GO:0071933,GO:0072332,GO:1901796" "transcription coactivator activity|actin binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytoskeleton|DNA repair|regulation of transcription by RNA polymerase II|cell cycle arrest|cell leading edge|Arp2/3 complex-mediated actin nucleation|positive regulation of apoptotic process|positive regulation of transcription, DNA-templated|positive regulation of DNA-binding transcription factor activity|'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex binding|intrinsic apoptotic signaling pathway by p53 class mediator|regulation of signal transduction by p53 class mediator" JOSD1 1893.20202 2074.585282 1711.818758 0.825137811 -0.277293003 0.241694365 1 19.8275078 16.0866568 9929 Josephin domain containing 1 "GO:0004843,GO:0005515,GO:0005829,GO:0005886,GO:0016020,GO:0016579,GO:0018215" thiol-dependent ubiquitin-specific protease activity|protein binding|cytosol|plasma membrane|membrane|protein deubiquitination|protein phosphopantetheinylation JOSD2 165.0156552 156.0620824 173.969228 1.114743731 0.156712087 0.699841381 1 9.368668737 10.26890416 126119 Josephin domain containing 2 "GO:0004843,GO:0005515,GO:0005829,GO:0016579,GO:0018215" thiol-dependent ubiquitin-specific protease activity|protein binding|cytosol|protein deubiquitination|protein phosphopantetheinylation JPH1 182.0340293 161.2641518 202.8039067 1.257588276 0.330659674 0.383815048 1 2.081850844 2.57430067 56704 junctophilin 1 "GO:0003674,GO:0005515,GO:0005654,GO:0005789,GO:0005886,GO:0007517,GO:0008307,GO:0014701,GO:0016021,GO:0016529,GO:0030018,GO:0030314,GO:0060314,GO:0060402" molecular_function|protein binding|nucleoplasm|endoplasmic reticulum membrane|plasma membrane|muscle organ development|structural constituent of muscle|junctional sarcoplasmic reticulum membrane|integral component of membrane|sarcoplasmic reticulum|Z disc|junctional membrane complex|regulation of ryanodine-sensitive calcium-release channel activity|calcium ion transport into cytosol JPH2 154.4429397 156.0620824 152.823797 0.979250018 -0.030250845 0.95753107 1 0.668707066 0.64387369 57158 junctophilin 2 "GO:0001786,GO:0003677,GO:0005515,GO:0005546,GO:0005547,GO:0005634,GO:0005789,GO:0005886,GO:0007275,GO:0010314,GO:0014701,GO:0016021,GO:0016529,GO:0030018,GO:0030314,GO:0032266,GO:0055024,GO:0055074,GO:0060314,GO:0060316,GO:0060402,GO:0070273,GO:0070300,GO:0080025" "phosphatidylserine binding|DNA binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|endoplasmic reticulum membrane|plasma membrane|multicellular organism development|phosphatidylinositol-5-phosphate binding|junctional sarcoplasmic reticulum membrane|integral component of membrane|sarcoplasmic reticulum|Z disc|junctional membrane complex|phosphatidylinositol-3-phosphate binding|regulation of cardiac muscle tissue development|calcium ion homeostasis|regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of ryanodine-sensitive calcium-release channel activity|calcium ion transport into cytosol|phosphatidylinositol-4-phosphate binding|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding" JPH4 31.6338582 10.40413883 52.86357758 5.081014245 2.345116509 0.001991549 0.275095265 0.12645178 0.631751874 84502 junctophilin 4 "GO:0005515,GO:0005789,GO:0005886,GO:0014701,GO:0016021,GO:0030314,GO:0048167,GO:0060314,GO:0060402" protein binding|endoplasmic reticulum membrane|plasma membrane|junctional sarcoplasmic reticulum membrane|integral component of membrane|junctional membrane complex|regulation of synaptic plasticity|regulation of ryanodine-sensitive calcium-release channel activity|calcium ion transport into cytosol JPT1 4108.944862 4365.576652 3852.313072 0.882429374 -0.180447279 0.44912566 1 80.98116173 70.26436692 51155 Jupiter microtubule associated homolog 1 "GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0031965" protein binding|nucleoplasm|nucleolus|cytoplasm|nuclear membrane JPT2 3317.442877 3545.730512 3089.155243 0.871232383 -0.198870516 0.401747573 1 51.21221127 43.87111945 90861 Jupiter microtubule associated homolog 2 "GO:0005634,GO:0005829,GO:0005886" nucleus|cytosol|plasma membrane JRK 886.7300371 935.3320805 838.1279936 0.89607532 -0.158308091 0.526248377 1 3.999115051 3.523543142 8629 Jrk helix-turn-helix protein "GO:0003677,GO:0003729,GO:0005515,GO:0005575,GO:0005634,GO:0005737,GO:0090263,GO:1990904" DNA binding|mRNA binding|protein binding|cellular_component|nucleus|cytoplasm|positive regulation of canonical Wnt signaling pathway|ribonucleoprotein complex JRKL 797.0066085 775.1083426 818.9048745 1.056503755 0.079297895 0.756706329 1 13.17391964 13.68539174 8690 JRK like "GO:0003677,GO:0005634,GO:0007417" DNA binding|nucleus|central nervous system development JTB 1167.459961 1252.658315 1082.261606 0.863971918 -0.210943675 0.385271474 1 52.51537468 44.6125732 10899 jumping translocation breakpoint "GO:0000278,GO:0000281,GO:0005737,GO:0005739,GO:0005813,GO:0005819,GO:0005887,GO:0006915,GO:0016020,GO:0019901,GO:0030496,GO:0045860" mitotic cell cycle|mitotic cytokinesis|cytoplasm|mitochondrion|centrosome|spindle|integral component of plasma membrane|apoptotic process|membrane|protein kinase binding|midbody|positive regulation of protein kinase activity JUN 3463.145365 3030.72564 3895.56509 1.285357222 0.362169364 0.127111718 1 49.66050266 62.76335228 3725 "Jun proto-oncogene, AP-1 transcription factor subunit" "GO:0000122,GO:0000228,GO:0000785,GO:0000791,GO:0000976,GO:0000978,GO:0000981,GO:0001102,GO:0001227,GO:0001228,GO:0001525,GO:0001836,GO:0003677,GO:0003700,GO:0003723,GO:0005096,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0005886,GO:0006357,GO:0006366,GO:0007179,GO:0007265,GO:0007568,GO:0007612,GO:0007623,GO:0008134,GO:0009314,GO:0009612,GO:0019899,GO:0031625,GO:0032496,GO:0034097,GO:0034614,GO:0035497,GO:0035976,GO:0038095,GO:0042127,GO:0042493,GO:0042542,GO:0042802,GO:0043065,GO:0043392,GO:0043525,GO:0043547,GO:0043922,GO:0043923,GO:0044389,GO:0044877,GO:0045657,GO:0045740,GO:0045892,GO:0045893,GO:0045944,GO:0051090,GO:0051365,GO:0051591,GO:0051726,GO:0051899,GO:0060395,GO:0070412,GO:0071276,GO:0071837,GO:1902895,GO:1904707,GO:1990441,GO:1990837,GO:2000144" "negative regulation of transcription by RNA polymerase II|nuclear chromosome|chromatin|euchromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II activating transcription factor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|release of cytochrome c from mitochondria|DNA binding|DNA-binding transcription factor activity|RNA binding|GTPase activator activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transforming growth factor beta receptor signaling pathway|Ras protein signal transduction|aging|learning|circadian rhythm|transcription factor binding|response to radiation|response to mechanical stimulus|enzyme binding|ubiquitin protein ligase binding|response to lipopolysaccharide|response to cytokine|cellular response to reactive oxygen species|cAMP response element binding|transcription factor AP-1 complex|Fc-epsilon receptor signaling pathway|regulation of cell population proliferation|response to drug|response to hydrogen peroxide|identical protein binding|positive regulation of apoptotic process|negative regulation of DNA binding|positive regulation of neuron apoptotic process|positive regulation of GTPase activity|negative regulation by host of viral transcription|positive regulation by host of viral transcription|ubiquitin-like protein ligase binding|protein-containing complex binding|positive regulation of monocyte differentiation|positive regulation of DNA replication|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of DNA-binding transcription factor activity|cellular response to potassium ion starvation|response to cAMP|regulation of cell cycle|membrane depolarization|SMAD protein signal transduction|R-SMAD binding|cellular response to cadmium ion|HMG box domain binding|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of vascular associated smooth muscle cell proliferation|negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|sequence-specific double-stranded DNA binding|positive regulation of DNA-templated transcription, initiation" "hsa01522,hsa04010,hsa04012,hsa04024,hsa04137,hsa04210,hsa04310,hsa04380,hsa04510,hsa04530,hsa04620,hsa04621,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04722,hsa04912,hsa04915,hsa04921,hsa04926,hsa04932,hsa04933,hsa05030,hsa05031,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05161,hsa05162,hsa05166,hsa05167,hsa05169,hsa05170,hsa05171,hsa05200,hsa05203,hsa05210,hsa05211,hsa05224,hsa05231,hsa05235,hsa05321,hsa05323,hsa05418" Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|cAMP signaling pathway|Mitophagy - animal|Apoptosis|Wnt signaling pathway|Osteoclast differentiation|Focal adhesion|Tight junction|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Cocaine addiction|Amphetamine addiction|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Hepatitis B|Measles|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Colorectal cancer|Renal cell carcinoma|Breast cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease|Rheumatoid arthritis|Fluid shear stress and atherosclerosis TF_bZIP JUNB 1653.193505 1577.267446 1729.119565 1.096275441 0.132610323 0.578057997 1 45.99774027 49.58237895 3726 "JunB proto-oncogene, AP-1 transcription factor subunit" "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001570,GO:0001649,GO:0001829,GO:0003677,GO:0005515,GO:0005654,GO:0005667,GO:0006357,GO:0008134,GO:0019221,GO:0030316,GO:0033687,GO:0035976,GO:0042127,GO:0045597,GO:0045944,GO:0046697,GO:0051726,GO:0060136,GO:0060716,GO:0071277,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|vasculogenesis|osteoblast differentiation|trophectodermal cell differentiation|DNA binding|protein binding|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription factor binding|cytokine-mediated signaling pathway|osteoclast differentiation|osteoblast proliferation|transcription factor AP-1 complex|regulation of cell population proliferation|positive regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|decidualization|regulation of cell cycle|embryonic process involved in female pregnancy|labyrinthine layer blood vessel development|cellular response to calcium ion|sequence-specific double-stranded DNA binding" "hsa04380,hsa04668,hsa04935" "Osteoclast differentiation|TNF signaling pathway|Growth hormone synthesis, secretion and action" TF_bZIP JUND 395.2358156 396.3976893 394.073942 0.994137838 -0.008482198 0.986561032 1 10.96683055 10.72010195 3727 "JunD proto-oncogene, AP-1 transcription factor subunit" "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0002076,GO:0005515,GO:0005654,GO:0005667,GO:0006357,GO:0006366,GO:0007568,GO:0007623,GO:0008134,GO:0009416,GO:0009612,GO:0014070,GO:0016922,GO:0019899,GO:0032496,GO:0032993,GO:0035976,GO:0042127,GO:0043434,GO:0045669,GO:0045944,GO:0051726,GO:0071277,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|osteoblast development|protein binding|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|aging|circadian rhythm|transcription factor binding|response to light stimulus|response to mechanical stimulus|response to organic cyclic compound|nuclear receptor binding|enzyme binding|response to lipopolysaccharide|protein-DNA complex|transcription factor AP-1 complex|regulation of cell population proliferation|response to peptide hormone|positive regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|regulation of cell cycle|cellular response to calcium ion|sequence-specific double-stranded DNA binding" "hsa04010,hsa04380,hsa04657,hsa04928" "MAPK signaling pathway|Osteoclast differentiation|IL-17 signaling pathway|Parathyroid hormone synthesis, secretion and action" TF_bZIP JUP 1811.451501 1707.319181 1915.58382 1.121983424 0.166051361 0.48433614 1 25.29608184 27.90685378 3728 junction plakoglobin "GO:0001533,GO:0001954,GO:0002159,GO:0003713,GO:0005198,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005882,GO:0005886,GO:0005911,GO:0005912,GO:0005915,GO:0005916,GO:0005925,GO:0009898,GO:0014704,GO:0015629,GO:0016327,GO:0016328,GO:0016342,GO:0016477,GO:0019901,GO:0019903,GO:0030018,GO:0030056,GO:0030057,GO:0031424,GO:0032993,GO:0034332,GO:0035257,GO:0035580,GO:0042127,GO:0042307,GO:0042803,GO:0043312,GO:0043537,GO:0044877,GO:0045294,GO:0045296,GO:0045766,GO:0045944,GO:0050839,GO:0050982,GO:0051091,GO:0070062,GO:0070268,GO:0071603,GO:0071665,GO:0071681,GO:0072659,GO:0086073,GO:0086083,GO:0086091,GO:0090263,GO:0098609,GO:0098911,GO:0106006,GO:1904813" cornified envelope|positive regulation of cell-matrix adhesion|desmosome assembly|transcription coactivator activity|structural molecule activity|protein binding|extracellular region|nucleus|cytoplasm|cytosol|cytoskeleton|intermediate filament|plasma membrane|cell-cell junction|adherens junction|zonula adherens|fascia adherens|focal adhesion|cytoplasmic side of plasma membrane|intercalated disc|actin cytoskeleton|apicolateral plasma membrane|lateral plasma membrane|catenin complex|cell migration|protein kinase binding|protein phosphatase binding|Z disc|hemidesmosome|desmosome|keratinization|protein-DNA complex|adherens junction organization|nuclear hormone receptor binding|specific granule lumen|regulation of cell population proliferation|positive regulation of protein import into nucleus|protein homodimerization activity|neutrophil degranulation|negative regulation of blood vessel endothelial cell migration|protein-containing complex binding|alpha-catenin binding|cadherin binding|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|cell adhesion molecule binding|detection of mechanical stimulus|positive regulation of DNA-binding transcription factor activity|extracellular exosome|cornification|endothelial cell-cell adhesion|gamma-catenin-TCF7L2 complex|cellular response to indole-3-methanol|protein localization to plasma membrane|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|regulation of heart rate by cardiac conduction|positive regulation of canonical Wnt signaling pathway|cell-cell adhesion|regulation of ventricular cardiac muscle cell action potential|cytoskeletal protein-membrane anchor activity|ficolin-1-rich granule lumen "hsa05200,hsa05202,hsa05221,hsa05226,hsa05412" Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy KALRN 7.406814487 5.202069413 9.61155956 1.847641543 0.88568489 0.555147706 1 0.014598774 0.02652194 8997 kalirin RhoGEF kinase "GO:0004674,GO:0005085,GO:0005524,GO:0005654,GO:0005829,GO:0006468,GO:0007165,GO:0007186,GO:0007399,GO:0007411,GO:0007417,GO:0007528,GO:0007595,GO:0007613,GO:0008344,GO:0015629,GO:0016192,GO:0035176,GO:0035556,GO:0042711,GO:0043065,GO:0043547,GO:0046872,GO:0046959,GO:0048013,GO:0051056,GO:0060125,GO:0060137,GO:0061003,GO:0070062,GO:0106310,GO:0106311" protein serine/threonine kinase activity|guanyl-nucleotide exchange factor activity|ATP binding|nucleoplasm|cytosol|protein phosphorylation|signal transduction|G protein-coupled receptor signaling pathway|nervous system development|axon guidance|central nervous system development|neuromuscular junction development|lactation|memory|adult locomotory behavior|actin cytoskeleton|vesicle-mediated transport|social behavior|intracellular signal transduction|maternal behavior|positive regulation of apoptotic process|positive regulation of GTPase activity|metal ion binding|habituation|ephrin receptor signaling pathway|regulation of small GTPase mediated signal transduction|negative regulation of growth hormone secretion|maternal process involved in parturition|positive regulation of dendritic spine morphogenesis|extracellular exosome|protein serine kinase activity|protein threonine kinase activity KANK1 355.0163349 324.6091314 385.4235384 1.187346569 0.247741098 0.410133073 1 1.636790697 1.910917018 23189 KN motif and ankyrin repeat domains 1 "GO:0005515,GO:0005634,GO:0005737,GO:0005856,GO:0005886,GO:0008013,GO:0008283,GO:0010977,GO:0030036,GO:0030177,GO:0030336,GO:0030837,GO:0032587,GO:0035023,GO:0035024,GO:0046627,GO:0090263,GO:0090303,GO:0090521,GO:1900025,GO:1900028,GO:2000114,GO:2000393" protein binding|nucleus|cytoplasm|cytoskeleton|plasma membrane|beta-catenin binding|cell population proliferation|negative regulation of neuron projection development|actin cytoskeleton organization|positive regulation of Wnt signaling pathway|negative regulation of cell migration|negative regulation of actin filament polymerization|ruffle membrane|regulation of Rho protein signal transduction|negative regulation of Rho protein signal transduction|negative regulation of insulin receptor signaling pathway|positive regulation of canonical Wnt signaling pathway|positive regulation of wound healing|glomerular visceral epithelial cell migration|negative regulation of substrate adhesion-dependent cell spreading|negative regulation of ruffle assembly|regulation of establishment of cell polarity|negative regulation of lamellipodium morphogenesis KANK2 2638.980513 2766.460514 2511.500513 0.907838916 -0.139491762 0.555781066 1 26.33153435 23.50477727 25959 KN motif and ankyrin repeat domains 2 "GO:0000122,GO:0005515,GO:0005737,GO:0005739,GO:0006915,GO:0008285,GO:0033147,GO:0035023,GO:0043069,GO:0070563,GO:0072073,GO:0090521,GO:2000134" negative regulation of transcription by RNA polymerase II|protein binding|cytoplasm|mitochondrion|apoptotic process|negative regulation of cell population proliferation|negative regulation of intracellular estrogen receptor signaling pathway|regulation of Rho protein signal transduction|negative regulation of programmed cell death|negative regulation of vitamin D receptor signaling pathway|kidney epithelium development|glomerular visceral epithelial cell migration|negative regulation of G1/S transition of mitotic cell cycle KANK3 5.003924597 5.202069413 4.80577978 0.923820772 -0.11431511 1 1 0.078558258 0.071359327 256949 KN motif and ankyrin repeat domains 3 "GO:0005737,GO:0005856,GO:0030837" cytoplasm|cytoskeleton|negative regulation of actin filament polymerization KANSL1 719.7027512 802.1591035 637.2463988 0.794413971 -0.3320371 0.193178702 1 4.059335961 3.170830654 284058 KAT8 regulatory NSL complex subunit 1 "GO:0000123,GO:0000777,GO:0005515,GO:0005634,GO:0005654,GO:0035035,GO:0043981,GO:0043982,GO:0043984,GO:0044545,GO:0071339" histone acetyltransferase complex|condensed chromosome kinetochore|protein binding|nucleus|nucleoplasm|histone acetyltransferase binding|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|NSL complex|MLL1 complex KANSL1L 172.2092336 193.5169822 150.9014851 0.7797842 -0.358853172 0.353884083 1 0.843004299 0.64636138 151050 KAT8 regulatory NSL complex subunit 1 like "GO:0035035,GO:0043981,GO:0043982,GO:0043984,GO:0044545" histone acetyltransferase binding|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|NSL complex KANSL2 588.0457356 550.3789439 625.7125274 1.136875846 0.185074711 0.485673857 1 12.37788145 13.83663667 54934 KAT8 regulatory NSL complex subunit 2 "GO:0000123,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0015629,GO:0043981,GO:0043982,GO:0043984,GO:0044545" histone acetyltransferase complex|protein binding|nucleoplasm|cytosol|plasma membrane|actin cytoskeleton|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|NSL complex KANSL3 1554.729126 1641.773107 1467.685145 0.893963446 -0.161712253 0.49814996 1 13.819939 12.14778413 55683 KAT8 regulatory NSL complex subunit 3 "GO:0000123,GO:0005654,GO:0043231,GO:0043981,GO:0043982,GO:0043984,GO:0044545,GO:0045944" histone acetyltransferase complex|nucleoplasm|intracellular membrane-bounded organelle|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|NSL complex|positive regulation of transcription by RNA polymerase II KARS1 3533.445072 3589.427895 3477.462249 0.968806827 -0.045719064 0.848307519 1 83.83420992 79.86006232 3735 lysyl-tRNA synthetase 1 "GO:0000049,GO:0000187,GO:0002276,GO:0002863,GO:0003877,GO:0004824,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0006418,GO:0006430,GO:0008033,GO:0010165,GO:0015966,GO:0016032,GO:0016597,GO:0017101,GO:0033209,GO:0042802,GO:0042803,GO:0043032,GO:0045893,GO:0070371" "tRNA binding|activation of MAPK activity|basophil activation involved in immune response|positive regulation of inflammatory response to antigenic stimulus|ATP adenylyltransferase activity|lysine-tRNA ligase activity|protein binding|ATP binding|extracellular space|nucleus|mitochondrion|mitochondrial matrix|cytosol|plasma membrane|tRNA aminoacylation for protein translation|lysyl-tRNA aminoacylation|tRNA processing|response to X-ray|diadenosine tetraphosphate biosynthetic process|viral process|amino acid binding|aminoacyl-tRNA synthetase multienzyme complex|tumor necrosis factor-mediated signaling pathway|identical protein binding|protein homodimerization activity|positive regulation of macrophage activation|positive regulation of transcription, DNA-templated|ERK1 and ERK2 cascade" hsa00970 Aminoacyl-tRNA biosynthesis KASH5 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.04870612 0.022121391 147872 KASH domain containing 5 "GO:0000724,GO:0000781,GO:0000800,GO:0005515,GO:0005640,GO:0007015,GO:0007129,GO:0007283,GO:0016021,GO:0034397,GO:0034993,GO:0042802,GO:0048477,GO:0051225,GO:0051653,GO:0070840,GO:0090172,GO:0090220,GO:0090619" "double-strand break repair via homologous recombination|chromosome, telomeric region|lateral element|protein binding|nuclear outer membrane|actin filament organization|homologous chromosome pairing at meiosis|spermatogenesis|integral component of membrane|telomere localization|meiotic nuclear membrane microtubule tethering complex|identical protein binding|oogenesis|spindle assembly|spindle localization|dynein complex binding|microtubule cytoskeleton organization involved in homologous chromosome segregation|chromosome localization to nuclear envelope involved in homologous chromosome segregation|meiotic spindle pole" KAT14 220.7721471 232.0122958 209.5319984 0.903107302 -0.147030685 0.683354822 1 3.07935086 2.73444824 57325 lysine acetyltransferase 14 "GO:0004402,GO:0005515,GO:0005634,GO:0005671,GO:0005737,GO:0030274,GO:0043966" histone acetyltransferase activity|protein binding|nucleus|Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|LIM domain binding|histone H3 acetylation KAT2A 1026.378855 1131.970304 920.7874058 0.813437775 -0.297896105 0.224560227 1 18.42927842 14.74021596 2648 lysine acetyltransferase 2A "GO:0000123,GO:0001701,GO:0001756,GO:0001816,GO:0001843,GO:0003682,GO:0003713,GO:0004402,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005671,GO:0005694,GO:0005813,GO:0006338,GO:0006357,GO:0007507,GO:0007616,GO:0008134,GO:0008283,GO:0010484,GO:0014070,GO:0016032,GO:0016573,GO:0016578,GO:0016579,GO:0018215,GO:0018393,GO:0019903,GO:0021537,GO:0022037,GO:0030901,GO:0030914,GO:0031346,GO:0031647,GO:0031667,GO:0033276,GO:0035066,GO:0035264,GO:0042826,GO:0043966,GO:0043983,GO:0043997,GO:0044154,GO:0045252,GO:0045589,GO:0045722,GO:0045815,GO:0045893,GO:0045944,GO:0046600,GO:0048167,GO:0048312,GO:0050863,GO:0060173,GO:0061035,GO:0061733,GO:0071356,GO:0071929,GO:0072686,GO:0106077,GO:0106078,GO:0106227,GO:0106229,GO:1903010,GO:1990090,GO:2000036,GO:2000727" "histone acetyltransferase complex|in utero embryonic development|somitogenesis|cytokine production|neural tube closure|chromatin binding|transcription coactivator activity|histone acetyltransferase activity|protein binding|extracellular space|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|chromosome|centrosome|chromatin remodeling|regulation of transcription by RNA polymerase II|heart development|long-term memory|transcription factor binding|cell population proliferation|H3 histone acetyltransferase activity|response to organic cyclic compound|viral process|histone acetylation|histone deubiquitination|protein deubiquitination|protein phosphopantetheinylation|internal peptidyl-lysine acetylation|protein phosphatase binding|telencephalon development|metencephalon development|midbrain development|STAGA complex|positive regulation of cell projection organization|regulation of protein stability|response to nutrient levels|transcription factor TFTC complex|positive regulation of histone acetylation|multicellular organism growth|histone deacetylase binding|histone H3 acetylation|histone H4-K12 acetylation|histone acetyltransferase activity (H4-K12 specific)|histone H3-K14 acetylation|oxoglutarate dehydrogenase complex|regulation of regulatory T cell differentiation|positive regulation of gluconeogenesis|positive regulation of gene expression, epigenetic|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of centriole replication|regulation of synaptic plasticity|intracellular distribution of mitochondria|regulation of T cell activation|limb development|regulation of cartilage development|peptide-lysine-N-acetyltransferase activity|cellular response to tumor necrosis factor|alpha-tubulin acetylation|mitotic spindle|histone succinylation|histone succinyltransferase activity|peptidyl-lysine glutarylation|histone glutaryltransferase activity|regulation of bone development|cellular response to nerve growth factor stimulus|regulation of stem cell population maintenance|positive regulation of cardiac muscle cell differentiation" "hsa04330,hsa04919,hsa05166,hsa05203" Notch signaling pathway|Thyroid hormone signaling pathway|Human T-cell leukemia virus 1 infection|Viral carcinogenesis chromosome_remodelling_factor KAT2B 508.6320968 446.3375557 570.9266379 1.279136453 0.355170173 0.192301585 1 5.121525481 6.441505651 8850 lysine acetyltransferase 2B "GO:0000125,GO:0000776,GO:0000977,GO:0003682,GO:0003712,GO:0003713,GO:0004145,GO:0004402,GO:0004468,GO:0004861,GO:0005515,GO:0005634,GO:0005654,GO:0005671,GO:0005813,GO:0005829,GO:0006338,GO:0006367,GO:0006473,GO:0007050,GO:0007219,GO:0007221,GO:0007507,GO:0008134,GO:0008285,GO:0010835,GO:0016032,GO:0016407,GO:0016579,GO:0018076,GO:0018215,GO:0018393,GO:0018394,GO:0019901,GO:0031672,GO:0031674,GO:0032869,GO:0032991,GO:0042641,GO:0042826,GO:0043966,GO:0043970,GO:0045652,GO:0045722,GO:0045736,GO:0045747,GO:0045815,GO:0045944,GO:0046600,GO:0048511,GO:0060173,GO:0061733,GO:2000233" "PCAF complex|kinetochore|RNA polymerase II transcription regulatory region sequence-specific DNA binding|chromatin binding|transcription coregulator activity|transcription coactivator activity|diamine N-acetyltransferase activity|histone acetyltransferase activity|lysine N-acetyltransferase activity, acting on acetyl phosphate as donor|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|centrosome|cytosol|chromatin remodeling|transcription initiation from RNA polymerase II promoter|protein acetylation|cell cycle arrest|Notch signaling pathway|positive regulation of transcription of Notch receptor target|heart development|transcription factor binding|negative regulation of cell population proliferation|regulation of protein ADP-ribosylation|viral process|acetyltransferase activity|protein deubiquitination|N-terminal peptidyl-lysine acetylation|protein phosphopantetheinylation|internal peptidyl-lysine acetylation|peptidyl-lysine acetylation|protein kinase binding|A band|I band|cellular response to insulin stimulus|protein-containing complex|actomyosin|histone deacetylase binding|histone H3 acetylation|histone H3-K9 acetylation|regulation of megakaryocyte differentiation|positive regulation of gluconeogenesis|negative regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of Notch signaling pathway|positive regulation of gene expression, epigenetic|positive regulation of transcription by RNA polymerase II|negative regulation of centriole replication|rhythmic process|limb development|peptide-lysine-N-acetyltransferase activity|negative regulation of rRNA processing" "hsa04330,hsa04919,hsa05166,hsa05203" Notch signaling pathway|Thyroid hormone signaling pathway|Human T-cell leukemia virus 1 infection|Viral carcinogenesis chromosome_remodelling_factor KAT5 578.8354961 548.2981162 609.3728761 1.111389695 0.152364769 0.56830709 1 13.05158909 14.26267336 10524 lysine acetyltransferase 5 "GO:0000122,GO:0000729,GO:0000812,GO:0003712,GO:0003713,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0006260,GO:0006302,GO:0006303,GO:0006978,GO:0010212,GO:0010508,GO:0016032,GO:0016407,GO:0016573,GO:0018215,GO:0018394,GO:0032703,GO:0032777,GO:0035267,GO:0040008,GO:0042393,GO:0043161,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0048471,GO:0061733,GO:0070491,GO:0071392,GO:1901796,GO:1901985,GO:1904837" "negative regulation of transcription by RNA polymerase II|DNA double-strand break processing|Swr1 complex|transcription coregulator activity|transcription coactivator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|DNA replication|double-strand break repair|double-strand break repair via nonhomologous end joining|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|response to ionizing radiation|positive regulation of autophagy|viral process|acetyltransferase activity|histone acetylation|protein phosphopantetheinylation|peptidyl-lysine acetylation|negative regulation of interleukin-2 production|Piccolo NuA4 histone acetyltransferase complex|NuA4 histone acetyltransferase complex|regulation of growth|histone binding|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|perinuclear region of cytoplasm|peptide-lysine-N-acetyltransferase activity|repressing transcription factor binding|cellular response to estradiol stimulus|regulation of signal transduction by p53 class mediator|positive regulation of protein acetylation|beta-catenin-TCF complex assembly" "hsa05017,hsa05166" Spinocerebellar ataxia|Human T-cell leukemia virus 1 infection other KAT6A 1172.636878 1325.487286 1019.786469 0.76936722 -0.378255731 0.118822059 1 6.94743865 5.255688025 7994 lysine acetyltransferase 6A "GO:0000786,GO:0003677,GO:0003712,GO:0003713,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006323,GO:0006334,GO:0006473,GO:0008134,GO:0008270,GO:0016407,GO:0016573,GO:0016605,GO:0016607,GO:0030099,GO:0042393,GO:0043966,GO:0045892,GO:0045893,GO:0045944,GO:0070776,GO:0090398,GO:1901796" "nucleosome|DNA binding|transcription coregulator activity|transcription coactivator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|DNA packaging|nucleosome assembly|protein acetylation|transcription factor binding|zinc ion binding|acetyltransferase activity|histone acetylation|PML body|nuclear speck|myeloid cell differentiation|histone binding|histone H3 acetylation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|MOZ/MORF histone acetyltransferase complex|cellular senescence|regulation of signal transduction by p53 class mediator" hsa04550 Signaling pathways regulating pluripotency of stem cells KAT6B 649.1326303 715.8047513 582.4605093 0.813714226 -0.297405881 0.251671369 1 4.734901336 3.78838424 23522 lysine acetyltransferase 6B "GO:0000786,GO:0003677,GO:0003712,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0006334,GO:0006355,GO:0008134,GO:0016407,GO:0016573,GO:0042393,GO:0043966,GO:0044877,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0070776" "nucleosome|DNA binding|transcription coregulator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|nucleosome assembly|regulation of transcription, DNA-templated|transcription factor binding|acetyltransferase activity|histone acetylation|histone binding|histone H3 acetylation|protein-containing complex binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|MOZ/MORF histone acetyltransferase complex" KAT7 995.7017368 1033.130985 958.2724881 0.927542104 -0.108515323 0.661520818 1 15.34120809 13.99150307 11143 lysine acetyltransferase 7 "GO:0000123,GO:0000775,GO:0001779,GO:0003688,GO:0003712,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005829,GO:0006260,GO:0006281,GO:0006355,GO:0008270,GO:0018393,GO:0030174,GO:0031098,GO:0032786,GO:0036409,GO:0042393,GO:0043966,GO:0043967,GO:0043981,GO:0043982,GO:0043983,GO:0043984,GO:0044154,GO:0045648,GO:0045740,GO:0045892,GO:0045944,GO:0072708,GO:0072710,GO:0072716,GO:0072720,GO:0072739,GO:0090240,GO:0090734,GO:1900182,GO:1902035,GO:2000819" "histone acetyltransferase complex|chromosome, centromeric region|natural killer cell differentiation|DNA replication origin binding|transcription coregulator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|cytosol|DNA replication|DNA repair|regulation of transcription, DNA-templated|zinc ion binding|internal peptidyl-lysine acetylation|regulation of DNA-dependent DNA replication initiation|stress-activated protein kinase signaling cascade|positive regulation of DNA-templated transcription, elongation|histone H3-K14 acetyltransferase complex|histone binding|histone H3 acetylation|histone H4 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K12 acetylation|histone H4-K16 acetylation|histone H3-K14 acetylation|positive regulation of erythrocyte differentiation|positive regulation of DNA replication|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|response to sorbitol|response to hydroxyurea|response to actinomycin D|response to dithiothreitol|response to anisomycin|positive regulation of histone H4 acetylation|site of DNA damage|positive regulation of protein localization to nucleus|positive regulation of hematopoietic stem cell proliferation|regulation of nucleotide-excision repair" KAT8 553.53344 527.4898385 579.5770415 1.098745415 0.135857145 0.615081873 1 12.2183868 13.20024902 84148 lysine acetyltransferase 8 "GO:0000123,GO:0000776,GO:0003712,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0008134,GO:0010506,GO:0016363,GO:0016407,GO:0016573,GO:0019899,GO:0030099,GO:0035064,GO:0042393,GO:0043981,GO:0043982,GO:0043984,GO:0043995,GO:0043996,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0046972,GO:0071339,GO:0072487" "histone acetyltransferase complex|kinetochore|transcription coregulator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|transcription factor binding|regulation of autophagy|nuclear matrix|acetyltransferase activity|histone acetylation|enzyme binding|myeloid cell differentiation|methylated histone binding|histone binding|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|histone acetyltransferase activity (H4-K5 specific)|histone acetyltransferase activity (H4-K8 specific)|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|histone acetyltransferase activity (H4-K16 specific)|MLL1 complex|MSL complex" other KATNA1 453.8808058 459.8629361 447.8986755 0.973982986 -0.038031525 0.899839794 1 9.936048465 9.515601587 11104 katanin catalytic subunit A1 "GO:0000922,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005819,GO:0005874,GO:0007049,GO:0008017,GO:0008568,GO:0015630,GO:0016853,GO:0016887,GO:0030496,GO:0031122,GO:0046982,GO:0051013,GO:0051301,GO:0097431" spindle pole|protein binding|ATP binding|nucleus|cytoplasm|centrosome|spindle|microtubule|cell cycle|microtubule binding|microtubule-severing ATPase activity|microtubule cytoskeleton|isomerase activity|ATPase activity|midbody|cytoplasmic microtubule organization|protein heterodimerization activity|microtubule severing|cell division|mitotic spindle pole KATNAL1 1631.677551 1403.518328 1859.836775 1.32512468 0.406128108 0.087764788 1 6.575069662 8.56699039 84056 katanin catalytic subunit A1 like 1 "GO:0000922,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005819,GO:0005874,GO:0007283,GO:0008017,GO:0008568,GO:0015630,GO:0016853,GO:0016887,GO:0031122,GO:0042802,GO:0051013" spindle pole|protein binding|ATP binding|nucleus|cytoplasm|centrosome|spindle|microtubule|spermatogenesis|microtubule binding|microtubule-severing ATPase activity|microtubule cytoskeleton|isomerase activity|ATPase activity|cytoplasmic microtubule organization|identical protein binding|microtubule severing KATNB1 820.8222714 807.3611729 834.2833698 1.033345915 0.04732328 0.8549565 1 16.45812908 16.72235233 10300 katanin regulatory subunit B1 "GO:0000922,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005819,GO:0005829,GO:0005874,GO:0005886,GO:0006605,GO:0007019,GO:0007026,GO:0007079,GO:0008017,GO:0008352,GO:0010942,GO:0010976,GO:0015630,GO:0016020,GO:0030426,GO:0030496,GO:0031117,GO:0043025,GO:0046982,GO:0050790,GO:0051013,GO:0051301,GO:0060590,GO:0070840" spindle pole|protein binding|nucleus|cytoplasm|centrosome|spindle|cytosol|microtubule|plasma membrane|protein targeting|microtubule depolymerization|negative regulation of microtubule depolymerization|mitotic chromosome movement towards spindle pole|microtubule binding|katanin complex|positive regulation of cell death|positive regulation of neuron projection development|microtubule cytoskeleton|membrane|growth cone|midbody|positive regulation of microtubule depolymerization|neuronal cell body|protein heterodimerization activity|regulation of catalytic activity|microtubule severing|cell division|ATPase regulator activity|dynein complex binding KATNBL1 450.1751905 413.0443114 487.3060697 1.179791263 0.23853163 0.396907132 1 4.902894964 5.687598663 79768 katanin regulatory subunit B1 like 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0008017,GO:0030496,GO:0032154,GO:0051495,GO:0072686,GO:0097431" protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|microtubule binding|midbody|cleavage furrow|positive regulation of cytoskeleton organization|mitotic spindle|mitotic spindle pole KATNIP 822.9817427 914.5238028 731.4396825 0.799803876 -0.322281822 0.198756677 1 7.027567248 5.526621133 23247 katanin interacting protein "GO:0005615,GO:0005737,GO:0005856,GO:0042995,GO:0090660" extracellular space|cytoplasm|cytoskeleton|cell projection|cerebrospinal fluid circulation KAZALD1 283.7624608 245.5376763 321.9872453 1.311355756 0.391059126 0.224515371 1 2.582048178 3.32932389 81621 Kazal type serine peptidase inhibitor domain 1 "GO:0001503,GO:0001558,GO:0005515,GO:0005520,GO:0005614,GO:0007275,GO:0009966,GO:0030154,GO:0030198" ossification|regulation of cell growth|protein binding|insulin-like growth factor binding|interstitial matrix|multicellular organism development|regulation of signal transduction|cell differentiation|extracellular matrix organization KAZN 248.3777136 300.6796121 196.075815 0.65210878 -0.61681545 0.065930428 1 0.996443012 0.638915894 23254 "kazrin, periplakin interacting protein" "GO:0001533,GO:0005515,GO:0005654,GO:0005829,GO:0005856,GO:0016607,GO:0030057,GO:0070268" cornified envelope|protein binding|nucleoplasm|cytosol|cytoskeleton|nuclear speck|desmosome|cornification KBTBD11 46.83874639 43.69738307 49.98010971 1.143778098 0.193807185 0.781181778 1 0.280766798 0.315761156 9920 kelch repeat and BTB domain containing 11 KBTBD2 1786.990485 1885.229955 1688.751015 0.895779854 -0.158783874 0.503845424 1 26.5325047 23.36956989 25948 kelch repeat and BTB domain containing 2 "GO:0006006,GO:0006629,GO:0010467,GO:0014065,GO:0032868" glucose metabolic process|lipid metabolic process|gene expression|phosphatidylinositol 3-kinase signaling|response to insulin KBTBD3 202.6888215 186.234085 219.143558 1.176710257 0.234759127 0.522250234 1 1.181522923 1.367045185 143879 kelch repeat and BTB domain containing 3 KBTBD4 420.448553 440.0950724 400.8020336 0.910716931 -0.13492539 0.641383173 1 8.721524378 7.809927246 55709 kelch repeat and BTB domain containing 4 KBTBD6 415.142688 389.1147921 441.1705838 1.133780038 0.181140774 0.530753952 1 3.967585268 4.423094863 89890 kelch repeat and BTB domain containing 6 "GO:0003674,GO:0005515,GO:0005575,GO:0005829,GO:0008150,GO:0043687" molecular_function|protein binding|cellular_component|cytosol|biological_process|post-translational protein modification KBTBD7 166.0956981 159.183324 173.0080721 1.086847967 0.120150144 0.770930602 1 1.793775641 1.916938139 84078 kelch repeat and BTB domain containing 7 "GO:0000165,GO:0003674,GO:0005515,GO:0005575,GO:0005829,GO:0008150,GO:0043687" MAPK cascade|molecular_function|protein binding|cellular_component|cytosol|biological_process|post-translational protein modification KBTBD8 28.94350473 28.09117483 29.79583464 1.060683108 0.084993698 0.959695194 1 0.40894009 0.42649753 84541 kelch repeat and BTB domain containing 8 "GO:0005515,GO:0005794,GO:0005819,GO:0005829,GO:0006417,GO:0006513,GO:0014029,GO:0014032,GO:0031463,GO:0043687" protein binding|Golgi apparatus|spindle|cytosol|regulation of translation|protein monoubiquitination|neural crest formation|neural crest cell development|Cul3-RING ubiquitin ligase complex|post-translational protein modification KCMF1 1581.776085 1506.519302 1657.032868 1.099908156 0.137383062 0.565076886 1 20.72169234 22.41056586 56888 potassium channel modulatory factor 1 "GO:0005576,GO:0005829,GO:0005886,GO:0008270,GO:0016567,GO:0043312,GO:0045202,GO:0061630,GO:0099536,GO:1904813" extracellular region|cytosol|plasma membrane|zinc ion binding|protein ubiquitination|neutrophil degranulation|synapse|ubiquitin protein ligase activity|synaptic signaling|ficolin-1-rich granule lumen KCNAB2 5049.126536 4735.963994 5362.289078 1.132248701 0.179190884 0.455692957 1 48.96352073 54.51118811 8514 potassium voltage-gated channel subfamily A regulatory beta subunit 2 "GO:0004033,GO:0005249,GO:0005515,GO:0005829,GO:0005874,GO:0005886,GO:0008076,GO:0015459,GO:0016020,GO:0031234,GO:0035579,GO:0043312,GO:0044224,GO:0044325,GO:0045202,GO:0055114,GO:0070821,GO:0070995,GO:0071805,GO:0098900,GO:1901379,GO:1990031,GO:2000008" aldo-keto reductase (NADP) activity|voltage-gated potassium channel activity|protein binding|cytosol|microtubule|plasma membrane|voltage-gated potassium channel complex|potassium channel regulator activity|membrane|extrinsic component of cytoplasmic side of plasma membrane|specific granule membrane|neutrophil degranulation|juxtaparanode region of axon|ion channel binding|synapse|oxidation-reduction process|tertiary granule membrane|NADPH oxidation|potassium ion transmembrane transport|regulation of action potential|regulation of potassium ion transmembrane transport|pinceau fiber|regulation of protein localization to cell surface KCNAB3 14.68971167 19.76786377 9.61155956 0.486221459 -1.040314528 0.292031197 1 0.308381923 0.147432834 9196 potassium voltage-gated channel subfamily A regulatory beta subunit 3 "GO:0004033,GO:0005249,GO:0005515,GO:0005737,GO:0005886,GO:0006813,GO:0008076,GO:0015459,GO:0044325,GO:0055114,GO:0071805,GO:1901379" aldo-keto reductase (NADP) activity|voltage-gated potassium channel activity|protein binding|cytoplasm|plasma membrane|potassium ion transport|voltage-gated potassium channel complex|potassium channel regulator activity|ion channel binding|oxidation-reduction process|potassium ion transmembrane transport|regulation of potassium ion transmembrane transport KCNC4 105.3698801 91.55642167 119.1833385 1.301747451 0.380449582 0.413481653 1 0.787080856 1.00743553 3749 potassium voltage-gated channel subfamily C member 4 "GO:0005249,GO:0005251,GO:0005267,GO:0005515,GO:0005886,GO:0006813,GO:0007268,GO:0008076,GO:0016021,GO:0030424,GO:0032590,GO:0032809,GO:0034765,GO:0045202,GO:0051260,GO:0071805" voltage-gated potassium channel activity|delayed rectifier potassium channel activity|potassium channel activity|protein binding|plasma membrane|potassium ion transport|chemical synaptic transmission|voltage-gated potassium channel complex|integral component of membrane|axon|dendrite membrane|neuronal cell body membrane|regulation of ion transmembrane transport|synapse|protein homooligomerization|potassium ion transmembrane transport KCND1 385.3418229 401.5997587 369.0838871 0.919034136 -0.121809646 0.682758543 1 3.548450499 3.206576256 3750 potassium voltage-gated channel subfamily D member 1 "GO:0005249,GO:0005250,GO:0005575,GO:0005886,GO:0008076,GO:0014069,GO:0016021,GO:0034765,GO:0043025,GO:0043197,GO:0045211,GO:0046872,GO:0051260,GO:0061337,GO:0071805" voltage-gated potassium channel activity|A-type (transient outward) potassium channel activity|cellular_component|plasma membrane|voltage-gated potassium channel complex|postsynaptic density|integral component of membrane|regulation of ion transmembrane transport|neuronal cell body|dendritic spine|postsynaptic membrane|metal ion binding|protein homooligomerization|cardiac conduction|potassium ion transmembrane transport KCND2 69.17304632 74.90979955 63.4362931 0.846835707 -0.239845992 0.67014305 1 0.413123729 0.343993694 3751 potassium voltage-gated channel subfamily D member 2 "GO:0001508,GO:0005249,GO:0005250,GO:0005515,GO:0005886,GO:0005887,GO:0007268,GO:0008076,GO:0014069,GO:0016021,GO:0019228,GO:0019233,GO:0031226,GO:0032809,GO:0034765,GO:0043197,GO:0043204,GO:0044853,GO:0045211,GO:0045475,GO:0046872,GO:0051260,GO:0060078,GO:0061337,GO:0071456,GO:0071805,GO:0098978,GO:0098982,GO:0099060,GO:1905030" action potential|voltage-gated potassium channel activity|A-type (transient outward) potassium channel activity|protein binding|plasma membrane|integral component of plasma membrane|chemical synaptic transmission|voltage-gated potassium channel complex|postsynaptic density|integral component of membrane|neuronal action potential|sensory perception of pain|intrinsic component of plasma membrane|neuronal cell body membrane|regulation of ion transmembrane transport|dendritic spine|perikaryon|plasma membrane raft|postsynaptic membrane|locomotor rhythm|metal ion binding|protein homooligomerization|regulation of postsynaptic membrane potential|cardiac conduction|cellular response to hypoxia|potassium ion transmembrane transport|glutamatergic synapse|GABA-ergic synapse|integral component of postsynaptic specialization membrane|voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential hsa04726 Serotonergic synapse KCNE1B 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.041995647 102723475 potassium voltage-gated channel subfamily E regulatory subunit 1B "GO:0005251,GO:0008076,GO:0015459,GO:0044325,GO:0060307,GO:0086005,GO:0086011,GO:0086091,GO:0097623,GO:0098915,GO:1902260,GO:1902282" delayed rectifier potassium channel activity|voltage-gated potassium channel complex|potassium channel regulator activity|ion channel binding|regulation of ventricular cardiac muscle cell membrane repolarization|ventricular cardiac muscle cell action potential|membrane repolarization during action potential|regulation of heart rate by cardiac conduction|potassium ion export across plasma membrane|membrane repolarization during ventricular cardiac muscle cell action potential|negative regulation of delayed rectifier potassium channel activity|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization hsa04261 Adrenergic signaling in cardiomyocytes KCNE5 5.04355356 6.242483296 3.844623824 0.615880514 -0.699277611 0.760739355 1 0.226170985 0.136963401 23630 potassium voltage-gated channel subfamily E regulatory subunit 5 "GO:0005249,GO:0005251,GO:0005515,GO:0005886,GO:0008016,GO:0008076,GO:0015459,GO:0044325,GO:0060048,GO:0060306,GO:0060307,GO:0060372,GO:0086005,GO:0086008,GO:0086011,GO:0086014,GO:0086091,GO:0097623,GO:0098915,GO:1901379,GO:1901380,GO:1901381,GO:1902260,GO:1902282,GO:1903765,GO:2001257" voltage-gated potassium channel activity|delayed rectifier potassium channel activity|protein binding|plasma membrane|regulation of heart contraction|voltage-gated potassium channel complex|potassium channel regulator activity|ion channel binding|cardiac muscle contraction|regulation of membrane repolarization|regulation of ventricular cardiac muscle cell membrane repolarization|regulation of atrial cardiac muscle cell membrane repolarization|ventricular cardiac muscle cell action potential|voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization|membrane repolarization during action potential|atrial cardiac muscle cell action potential|regulation of heart rate by cardiac conduction|potassium ion export across plasma membrane|membrane repolarization during ventricular cardiac muscle cell action potential|regulation of potassium ion transmembrane transport|negative regulation of potassium ion transmembrane transport|positive regulation of potassium ion transmembrane transport|negative regulation of delayed rectifier potassium channel activity|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|negative regulation of potassium ion export across plasma membrane|regulation of cation channel activity KCNH3 19.13883078 10.40413883 27.87352272 2.679080238 1.42173779 0.106799143 1 0.120943099 0.318594293 23416 potassium voltage-gated channel subfamily H member 3 "GO:0005249,GO:0005515,GO:0005886,GO:0005887,GO:0006813,GO:0016021,GO:0034765,GO:0042391,GO:0071805" voltage-gated potassium channel activity|protein binding|plasma membrane|integral component of plasma membrane|potassium ion transport|integral component of membrane|regulation of ion transmembrane transport|regulation of membrane potential|potassium ion transmembrane transport KCNH8 6.604174384 9.363724944 3.844623824 0.41058701 -1.284240111 0.3924594 1 0.115972335 0.046819933 131096 potassium voltage-gated channel subfamily H member 8 "GO:0005249,GO:0005886,GO:0005887,GO:0034765,GO:0042391,GO:0071805" voltage-gated potassium channel activity|plasma membrane|integral component of plasma membrane|regulation of ion transmembrane transport|regulation of membrane potential|potassium ion transmembrane transport KCNIP2 108.4760305 135.2538047 81.69825626 0.604036658 -0.727291987 0.109557308 1 2.567857337 1.525124742 30819 potassium voltage-gated channel interacting protein 2 "GO:0005250,GO:0005509,GO:0005513,GO:0005515,GO:0005737,GO:0005886,GO:0006813,GO:0006936,GO:0007165,GO:0007268,GO:0008016,GO:0008076,GO:0015459,GO:0034705,GO:0044325,GO:0045163,GO:0045202,GO:0046923,GO:0047485,GO:0061337,GO:0086008,GO:0086009,GO:0086013,GO:0097623,GO:1901379,GO:1903766,GO:1903818" A-type (transient outward) potassium channel activity|calcium ion binding|detection of calcium ion|protein binding|cytoplasm|plasma membrane|potassium ion transport|muscle contraction|signal transduction|chemical synaptic transmission|regulation of heart contraction|voltage-gated potassium channel complex|potassium channel regulator activity|potassium channel complex|ion channel binding|clustering of voltage-gated potassium channels|synapse|ER retention sequence binding|protein N-terminus binding|cardiac conduction|voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization|membrane repolarization|membrane repolarization during cardiac muscle cell action potential|potassium ion export across plasma membrane|regulation of potassium ion transmembrane transport|positive regulation of potassium ion export across plasma membrane|positive regulation of voltage-gated potassium channel activity KCNIP3 41.5920176 44.73779695 38.44623824 0.85936816 -0.21865177 0.762676756 1 0.711434445 0.601153425 30818 potassium voltage-gated channel interacting protein 3 "GO:0000122,GO:0000978,GO:0001227,GO:0005244,GO:0005267,GO:0005509,GO:0005515,GO:0005634,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0006886,GO:0006915,GO:0007165,GO:0008076,GO:0015459,GO:0030425,GO:0032993,GO:0043679,GO:0044325,GO:0061337,GO:0071805,GO:0072659,GO:1901379" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|voltage-gated ion channel activity|potassium channel activity|calcium ion binding|protein binding|nucleus|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|intracellular protein transport|apoptotic process|signal transduction|voltage-gated potassium channel complex|potassium channel regulator activity|dendrite|protein-DNA complex|axon terminus|ion channel binding|cardiac conduction|potassium ion transmembrane transport|protein localization to plasma membrane|regulation of potassium ion transmembrane transport" KCNJ11 3.562190663 5.202069413 1.922311912 0.369528309 -1.436243205 0.543489417 1 0.071112931 0.02583851 3767 potassium inwardly rectifying channel subfamily J member 11 "GO:0001669,GO:0002931,GO:0005242,GO:0005249,GO:0005515,GO:0005524,GO:0005635,GO:0005739,GO:0005768,GO:0005783,GO:0005829,GO:0005886,GO:0005887,GO:0006006,GO:0008022,GO:0008282,GO:0014704,GO:0015272,GO:0019829,GO:0030315,GO:0030506,GO:0030673,GO:0030955,GO:0031072,GO:0032355,GO:0033198,GO:0033574,GO:0034765,GO:0042391,GO:0042493,GO:0043025,GO:0043209,GO:0044325,GO:0046676,GO:0050796,GO:0050877,GO:0055085,GO:0070852,GO:0071316,GO:0071333,GO:0071356,GO:0071805,GO:0098662,GO:1903078,GO:1903779,GO:1990573,GO:2001259" acrosomal vesicle|response to ischemia|inward rectifier potassium channel activity|voltage-gated potassium channel activity|protein binding|ATP binding|nuclear envelope|mitochondrion|endosome|endoplasmic reticulum|cytosol|plasma membrane|integral component of plasma membrane|glucose metabolic process|protein C-terminus binding|inward rectifying potassium channel|intercalated disc|ATP-activated inward rectifier potassium channel activity|ATPase-coupled cation transmembrane transporter activity|T-tubule|ankyrin binding|axolemma|potassium ion binding|heat shock protein binding|response to estradiol|response to ATP|response to testosterone|regulation of ion transmembrane transport|regulation of membrane potential|response to drug|neuronal cell body|myelin sheath|ion channel binding|negative regulation of insulin secretion|regulation of insulin secretion|nervous system process|transmembrane transport|cell body fiber|cellular response to nicotine|cellular response to glucose stimulus|cellular response to tumor necrosis factor|potassium ion transmembrane transport|inorganic cation transmembrane transport|positive regulation of protein localization to plasma membrane|regulation of cardiac conduction|potassium ion import across plasma membrane|positive regulation of cation channel activity "hsa04911,hsa04929,hsa04930" Insulin secretion|GnRH secretion|Type II diabetes mellitus KCNJ12 6.564545421 8.323311061 4.80577978 0.577387982 -0.792387015 0.636893371 1 0.07549283 0.042859256 3768 potassium inwardly rectifying channel subfamily J member 12 "GO:0005242,GO:0005515,GO:0005886,GO:0006813,GO:0006936,GO:0008016,GO:0016021,GO:0031224,GO:0034765,GO:0051289,GO:0061337,GO:1990573" inward rectifier potassium channel activity|protein binding|plasma membrane|potassium ion transport|muscle contraction|regulation of heart contraction|integral component of membrane|intrinsic component of membrane|regulation of ion transmembrane transport|protein homotetramerization|cardiac conduction|potassium ion import across plasma membrane "hsa04725,hsa04921" Cholinergic synapse|Oxytocin signaling pathway KCNJ14 16.3742498 13.52538047 19.22311912 1.421262726 0.507173267 0.621215712 1 0.187292345 0.261737272 3770 potassium inwardly rectifying channel subfamily J member 14 "GO:0005242,GO:0005886,GO:0008076,GO:0030425,GO:0034765,GO:0043025,GO:0061337,GO:1990573" inward rectifier potassium channel activity|plasma membrane|voltage-gated potassium channel complex|dendrite|regulation of ion transmembrane transport|neuronal cell body|cardiac conduction|potassium ion import across plasma membrane "hsa04725,hsa04921" Cholinergic synapse|Oxytocin signaling pathway KCNJ2 299.7297457 374.5489978 224.9104937 0.600483502 -0.735803487 0.019393836 0.80560651 3.707844856 2.189242206 3759 potassium inwardly rectifying channel subfamily J member 2 "GO:0005242,GO:0005515,GO:0005546,GO:0005790,GO:0005791,GO:0005794,GO:0005886,GO:0005887,GO:0006813,GO:0008076,GO:0014704,GO:0014861,GO:0015693,GO:0030007,GO:0030315,GO:0031224,GO:0034765,GO:0042802,GO:0043025,GO:0043197,GO:0051289,GO:0055119,GO:0060075,GO:0060306,GO:0061337,GO:0071260,GO:0071805,GO:0086002,GO:0086004,GO:0086008,GO:0086011,GO:0086012,GO:0086013,GO:0086091,GO:0090076,GO:1901381,GO:1990573" "inward rectifier potassium channel activity|protein binding|phosphatidylinositol-4,5-bisphosphate binding|smooth endoplasmic reticulum|rough endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|potassium ion transport|voltage-gated potassium channel complex|intercalated disc|regulation of skeletal muscle contraction via regulation of action potential|magnesium ion transport|cellular potassium ion homeostasis|T-tubule|intrinsic component of membrane|regulation of ion transmembrane transport|identical protein binding|neuronal cell body|dendritic spine|protein homotetramerization|relaxation of cardiac muscle|regulation of resting membrane potential|regulation of membrane repolarization|cardiac conduction|cellular response to mechanical stimulus|potassium ion transmembrane transport|cardiac muscle cell action potential involved in contraction|regulation of cardiac muscle cell contraction|voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization|membrane repolarization during action potential|membrane depolarization during cardiac muscle cell action potential|membrane repolarization during cardiac muscle cell action potential|regulation of heart rate by cardiac conduction|relaxation of skeletal muscle|positive regulation of potassium ion transmembrane transport|potassium ion import across plasma membrane" "hsa04725,hsa04921,hsa04924,hsa04971" Cholinergic synapse|Oxytocin signaling pathway|Renin secretion|Gastric acid secretion KCNJ3 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.03489942 0.010567101 3760 potassium inwardly rectifying channel subfamily J member 3 "GO:0005242,GO:0005515,GO:0005886,GO:0006813,GO:0008076,GO:0009897,GO:0015467,GO:0030315,GO:0034765,GO:0051602,GO:0086089,GO:0086091,GO:0098688,GO:0098914,GO:0098915,GO:0099056,GO:0099625,GO:1902282,GO:1990573" inward rectifier potassium channel activity|protein binding|plasma membrane|potassium ion transport|voltage-gated potassium channel complex|external side of plasma membrane|G-protein activated inward rectifier potassium channel activity|T-tubule|regulation of ion transmembrane transport|response to electrical stimulus|voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization|regulation of heart rate by cardiac conduction|parallel fiber to Purkinje cell synapse|membrane repolarization during atrial cardiac muscle cell action potential|membrane repolarization during ventricular cardiac muscle cell action potential|integral component of presynaptic membrane|ventricular cardiac muscle cell membrane repolarization|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|potassium ion import across plasma membrane "hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04915,hsa04921,hsa04929,hsa05032" Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Estrogen signaling pathway|Oxytocin signaling pathway|GnRH secretion|Morphine addiction KCNJ8 219.8260824 194.5573961 245.0947688 1.259755598 0.333143867 0.344836687 1 4.238028835 5.249541613 3764 potassium inwardly rectifying channel subfamily J member 8 "GO:0001822,GO:0005242,GO:0005515,GO:0005524,GO:0005739,GO:0005886,GO:0006813,GO:0007507,GO:0008076,GO:0008282,GO:0015272,GO:0017098,GO:0019829,GO:0030016,GO:0031004,GO:0032496,GO:0034765,GO:0042383,GO:0043330,GO:0051607,GO:0071805,GO:0098662,GO:0098915,GO:0150104,GO:1902282,GO:1990573" kidney development|inward rectifier potassium channel activity|protein binding|ATP binding|mitochondrion|plasma membrane|potassium ion transport|heart development|voltage-gated potassium channel complex|inward rectifying potassium channel|ATP-activated inward rectifier potassium channel activity|sulfonylurea receptor binding|ATPase-coupled cation transmembrane transporter activity|myofibril|potassium ion-transporting ATPase complex|response to lipopolysaccharide|regulation of ion transmembrane transport|sarcolemma|response to exogenous dsRNA|defense response to virus|potassium ion transmembrane transport|inorganic cation transmembrane transport|membrane repolarization during ventricular cardiac muscle cell action potential|transport across blood-brain barrier|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|potassium ion import across plasma membrane hsa04022 cGMP-PKG signaling pathway KCNK1 470.7752625 474.4287305 467.1217946 0.984598454 -0.02239262 0.943863521 1 9.254162786 8.959163512 3775 potassium two pore domain channel subfamily K member 1 "GO:0005242,GO:0005249,GO:0005267,GO:0005272,GO:0005515,GO:0005886,GO:0005887,GO:0006813,GO:0008076,GO:0016021,GO:0016324,GO:0022841,GO:0030322,GO:0030425,GO:0031526,GO:0034705,GO:0035094,GO:0035725,GO:0042802,GO:0043204,GO:0043231,GO:0055037,GO:0060075,GO:0061337,GO:0071805,GO:0097060,GO:1902937" inward rectifier potassium channel activity|voltage-gated potassium channel activity|potassium channel activity|sodium channel activity|protein binding|plasma membrane|integral component of plasma membrane|potassium ion transport|voltage-gated potassium channel complex|integral component of membrane|apical plasma membrane|potassium ion leak channel activity|stabilization of membrane potential|dendrite|brush border membrane|potassium channel complex|response to nicotine|sodium ion transmembrane transport|identical protein binding|perikaryon|intracellular membrane-bounded organelle|recycling endosome|regulation of resting membrane potential|cardiac conduction|potassium ion transmembrane transport|synaptic membrane|inward rectifier potassium channel complex KCNK2 45.15923868 37.45489978 52.86357758 1.411392846 0.497119602 0.435545365 1 0.314985686 0.437129291 3776 potassium two pore domain channel subfamily K member 2 "GO:0003231,GO:0005634,GO:0005789,GO:0005886,GO:0005887,GO:0007186,GO:0007613,GO:0008076,GO:0009612,GO:0009986,GO:0010942,GO:0015271,GO:0016324,GO:0022841,GO:0030322,GO:0043025,GO:0044305,GO:0048678,GO:0060044,GO:0071456,GO:0071805,GO:0090102,GO:0097449,GO:1900039,GO:2000279" cardiac ventricle development|nucleus|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|memory|voltage-gated potassium channel complex|response to mechanical stimulus|cell surface|positive regulation of cell death|outward rectifier potassium channel activity|apical plasma membrane|potassium ion leak channel activity|stabilization of membrane potential|neuronal cell body|calyx of Held|response to axon injury|negative regulation of cardiac muscle cell proliferation|cellular response to hypoxia|potassium ion transmembrane transport|cochlea development|astrocyte projection|positive regulation of cellular response to hypoxia|negative regulation of DNA biosynthetic process "hsa04927,hsa04934,hsa04971" Cortisol synthesis and secretion|Cushing syndrome|Gastric acid secretion KCNK3 392.9065389 511.8836303 273.9294475 0.535140081 -0.902011506 0.001977453 0.275095265 4.360461061 2.294410235 3777 potassium two pore domain channel subfamily K member 3 "GO:0005216,GO:0005252,GO:0005267,GO:0005886,GO:0005887,GO:0006813,GO:0007268,GO:0007420,GO:0008022,GO:0022841,GO:0030322,GO:0034220,GO:0042493,GO:0044548,GO:0045202,GO:0051481,GO:0061337,GO:0071294,GO:0071456,GO:0071805,GO:0090102" ion channel activity|open rectifier potassium channel activity|potassium channel activity|plasma membrane|integral component of plasma membrane|potassium ion transport|chemical synaptic transmission|brain development|protein C-terminus binding|potassium ion leak channel activity|stabilization of membrane potential|ion transmembrane transport|response to drug|S100 protein binding|synapse|negative regulation of cytosolic calcium ion concentration|cardiac conduction|cellular response to zinc ion|cellular response to hypoxia|potassium ion transmembrane transport|cochlea development "hsa04925,hsa04927,hsa04934" Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome KCNK6 238.9944813 230.9718819 247.0170807 1.069468191 0.096893573 0.786317561 1 4.2402975 4.458978499 9424 potassium two pore domain channel subfamily K member 6 "GO:0003085,GO:0005242,GO:0005886,GO:0005887,GO:0006813,GO:0008076,GO:0022841,GO:0030322,GO:0034765,GO:0060075,GO:0061337,GO:0071805" negative regulation of systemic arterial blood pressure|inward rectifier potassium channel activity|plasma membrane|integral component of plasma membrane|potassium ion transport|voltage-gated potassium channel complex|potassium ion leak channel activity|stabilization of membrane potential|regulation of ion transmembrane transport|regulation of resting membrane potential|cardiac conduction|potassium ion transmembrane transport KCNK9 3.923881751 2.080827765 5.766935736 2.771462315 1.470647391 0.503574097 1 0.020784195 0.056638711 51305 potassium two pore domain channel subfamily K member 9 "GO:0005249,GO:0005267,GO:0005886,GO:0005887,GO:0006813,GO:0008021,GO:0022841,GO:0030322,GO:0071805,GO:1990573" voltage-gated potassium channel activity|potassium channel activity|plasma membrane|integral component of plasma membrane|potassium ion transport|synaptic vesicle|potassium ion leak channel activity|stabilization of membrane potential|potassium ion transmembrane transport|potassium ion import across plasma membrane hsa04925 Aldosterone synthesis and secretion KCNMA1 17.1768899 9.363724944 24.99005486 2.668815563 1.416199607 0.124877833 1 0.013612029 0.035720094 3778 potassium calcium-activated channel subfamily M alpha 1 "GO:0001666,GO:0003779,GO:0005249,GO:0005515,GO:0005886,GO:0005901,GO:0006813,GO:0006970,GO:0008076,GO:0015269,GO:0016021,GO:0016324,GO:0030007,GO:0034465,GO:0034765,GO:0042391,GO:0043065,GO:0045211,GO:0045794,GO:0046872,GO:0051592,GO:0060072,GO:0060073,GO:0060083,GO:0060087,GO:0071805" response to hypoxia|actin binding|voltage-gated potassium channel activity|protein binding|plasma membrane|caveola|potassium ion transport|response to osmotic stress|voltage-gated potassium channel complex|calcium-activated potassium channel activity|integral component of membrane|apical plasma membrane|cellular potassium ion homeostasis|response to carbon monoxide|regulation of ion transmembrane transport|regulation of membrane potential|positive regulation of apoptotic process|postsynaptic membrane|negative regulation of cell volume|metal ion binding|response to calcium ion|large conductance calcium-activated potassium channel activity|micturition|smooth muscle contraction involved in micturition|relaxation of vascular associated smooth muscle|potassium ion transmembrane transport "hsa04022,hsa04270,hsa04911,hsa04924,hsa04970,hsa04972" cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Insulin secretion|Renin secretion|Salivary secretion|Pancreatic secretion KCNMB3 35.18598803 40.57614142 29.79583464 0.734319075 -0.445521018 0.531642665 1 0.676710654 0.488606232 27094 potassium calcium-activated channel subfamily M regulatory beta subunit 3 "GO:0001508,GO:0005513,GO:0005886,GO:0005887,GO:0006813,GO:0008076,GO:0015269,GO:0015459,GO:0019228,GO:0071805" action potential|detection of calcium ion|plasma membrane|integral component of plasma membrane|potassium ion transport|voltage-gated potassium channel complex|calcium-activated potassium channel activity|potassium channel regulator activity|neuronal action potential|potassium ion transmembrane transport "hsa04022,hsa04270,hsa04911" cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Insulin secretion KCNMB4 106.0039435 108.2030438 103.8048432 0.95935234 -0.059867326 0.917369475 1 0.617802244 0.582772164 27345 potassium calcium-activated channel subfamily M regulatory beta subunit 4 "GO:0001508,GO:0005513,GO:0005515,GO:0005886,GO:0005887,GO:0006813,GO:0007268,GO:0008076,GO:0015269,GO:0015459,GO:0019228,GO:0019229,GO:0045202,GO:0046928,GO:0071805" action potential|detection of calcium ion|protein binding|plasma membrane|integral component of plasma membrane|potassium ion transport|chemical synaptic transmission|voltage-gated potassium channel complex|calcium-activated potassium channel activity|potassium channel regulator activity|neuronal action potential|regulation of vasoconstriction|synapse|regulation of neurotransmitter secretion|potassium ion transmembrane transport "hsa04022,hsa04270,hsa04911" cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Insulin secretion KCNN4 481.4127591 413.0443114 549.7812068 1.331046553 0.41256103 0.134712017 1 11.26963996 14.74940378 3783 potassium calcium-activated channel subfamily N member 4 "GO:0002376,GO:0005267,GO:0005515,GO:0005516,GO:0005886,GO:0006811,GO:0006813,GO:0006816,GO:0006884,GO:0006952,GO:0008076,GO:0015269,GO:0016286,GO:0019903,GO:0022894,GO:0030322,GO:0031982,GO:0043005,GO:0043025,GO:0045332,GO:0046541,GO:0050714,GO:0050862,GO:0071805" immune system process|potassium channel activity|protein binding|calmodulin binding|plasma membrane|ion transport|potassium ion transport|calcium ion transport|cell volume homeostasis|defense response|voltage-gated potassium channel complex|calcium-activated potassium channel activity|small conductance calcium-activated potassium channel activity|protein phosphatase binding|Intermediate conductance calcium-activated potassium channel activity|stabilization of membrane potential|vesicle|neuron projection|neuronal cell body|phospholipid translocation|saliva secretion|positive regulation of protein secretion|positive regulation of T cell receptor signaling pathway|potassium ion transmembrane transport "hsa04911,hsa04929,hsa04970,hsa04974" Insulin secretion|GnRH secretion|Salivary secretion|Protein digestion and absorption KCNQ3 94.15304034 99.87973273 88.42634795 0.88532824 -0.175715655 0.729566296 1 0.214814128 0.186998592 3786 potassium voltage-gated channel subfamily Q member 3 "GO:0005249,GO:0005251,GO:0005515,GO:0005516,GO:0005886,GO:0005887,GO:0007268,GO:0008076,GO:0009986,GO:0016021,GO:0033268,GO:0034765,GO:0043194,GO:0045202,GO:0060081,GO:0071805" voltage-gated potassium channel activity|delayed rectifier potassium channel activity|protein binding|calmodulin binding|plasma membrane|integral component of plasma membrane|chemical synaptic transmission|voltage-gated potassium channel complex|cell surface|integral component of membrane|node of Ranvier|regulation of ion transmembrane transport|axon initial segment|synapse|membrane hyperpolarization|potassium ion transmembrane transport hsa04725 Cholinergic synapse KCNQ4 5.484502575 5.202069413 5.766935736 1.108584926 0.148719296 1 1 0.063675432 0.069408402 9132 potassium voltage-gated channel subfamily Q member 4 "GO:0005249,GO:0005251,GO:0005267,GO:0005515,GO:0005516,GO:0005886,GO:0006813,GO:0007605,GO:0008076,GO:0009925,GO:0016021,GO:0034765,GO:0042472,GO:0071805" voltage-gated potassium channel activity|delayed rectifier potassium channel activity|potassium channel activity|protein binding|calmodulin binding|plasma membrane|potassium ion transport|sensory perception of sound|voltage-gated potassium channel complex|basal plasma membrane|integral component of membrane|regulation of ion transmembrane transport|inner ear morphogenesis|potassium ion transmembrane transport hsa04725 Cholinergic synapse KCNRG 6.445658531 5.202069413 7.689247648 1.478113235 0.563756795 0.78195947 1 0.193466818 0.281180612 283518 potassium channel regulator "GO:0005515,GO:0005783,GO:0042802,GO:0051260,GO:1902260" protein binding|endoplasmic reticulum|identical protein binding|protein homooligomerization|negative regulation of delayed rectifier potassium channel activity KCNS1 74.85569371 85.31393838 64.39744905 0.754829167 -0.405777924 0.441102692 1 0.691742341 0.513409868 3787 potassium voltage-gated channel modifier subfamily S member 1 "GO:0005249,GO:0005251,GO:0005515,GO:0005886,GO:0006813,GO:0008076,GO:0015459,GO:0016021,GO:0048471,GO:0051260,GO:0071805,GO:1902259" voltage-gated potassium channel activity|delayed rectifier potassium channel activity|protein binding|plasma membrane|potassium ion transport|voltage-gated potassium channel complex|potassium channel regulator activity|integral component of membrane|perinuclear region of cytoplasm|protein homooligomerization|potassium ion transmembrane transport|regulation of delayed rectifier potassium channel activity KCNS3 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.057202929 0.01732032 3790 potassium voltage-gated channel modifier subfamily S member 3 "GO:0005249,GO:0005251,GO:0005794,GO:0005829,GO:0005886,GO:0006813,GO:0008076,GO:0015459,GO:0016021,GO:0034765,GO:0050796,GO:0051260,GO:0071805" voltage-gated potassium channel activity|delayed rectifier potassium channel activity|Golgi apparatus|cytosol|plasma membrane|potassium ion transport|voltage-gated potassium channel complex|potassium channel regulator activity|integral component of membrane|regulation of ion transmembrane transport|regulation of insulin secretion|protein homooligomerization|potassium ion transmembrane transport KCNT2 111.3745896 97.79890497 124.9502743 1.277624472 0.353463851 0.439164087 1 0.361175546 0.45372503 343450 potassium sodium-activated channel subfamily T member 2 "GO:0005228,GO:0005524,GO:0005886,GO:0015271,GO:0016021,GO:0070089,GO:0097623" intracellular sodium activated potassium channel activity|ATP binding|plasma membrane|outward rectifier potassium channel activity|integral component of membrane|chloride-activated potassium channel activity|potassium ion export across plasma membrane KCNU1 26.38209899 23.9295193 28.83467868 1.204983615 0.26901353 0.764127829 1 0.343022956 0.406420406 157855 potassium calcium-activated channel subfamily U member 1 "GO:0005244,GO:0005886,GO:0016021,GO:0022414,GO:0034765,GO:0035036,GO:0060072,GO:0071805" voltage-gated ion channel activity|plasma membrane|integral component of membrane|reproductive process|regulation of ion transmembrane transport|sperm-egg recognition|large conductance calcium-activated potassium channel activity|potassium ion transmembrane transport "hsa04022,hsa04270,hsa04911" cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Insulin secretion KCP 3.562190663 5.202069413 1.922311912 0.369528309 -1.436243205 0.543489417 1 0.043914091 0.015955955 375616 kielin cysteine rich BMP regulator GO:0005576 extracellular region KCTD1 339.3799441 368.3065145 310.4533738 0.842921213 -0.246530305 0.418528855 1 4.546805866 3.768465758 284252 potassium channel tetramerization domain containing 1 "GO:0000122,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0008134,GO:0034451,GO:0042802,GO:0045171,GO:0045892,GO:0051260" "negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|transcription factor binding|centriolar satellite|identical protein binding|intercellular bridge|negative regulation of transcription, DNA-templated|protein homooligomerization" KCTD10 1568.056976 1562.701652 1573.4123 1.00685393 0.009854399 0.969970346 1 21.25886185 21.04639214 83892 potassium channel tetramerization domain containing 10 "GO:0004842,GO:0005112,GO:0005515,GO:0005654,GO:0005829,GO:0006511,GO:0016567,GO:0031463,GO:0035024,GO:0042802,GO:0043161,GO:0051260" ubiquitin-protein transferase activity|Notch binding|protein binding|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|Cul3-RING ubiquitin ligase complex|negative regulation of Rho protein signal transduction|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein homooligomerization KCTD11 348.5209865 343.3365813 353.7053918 1.030200133 0.042924632 0.896168669 1 6.583989334 6.669325271 147040 potassium channel tetramerization domain containing 11 "GO:0007049,GO:0007275,GO:0016567,GO:0016740,GO:0040008,GO:0042802,GO:0045666,GO:0051260" cell cycle|multicellular organism development|protein ubiquitination|transferase activity|regulation of growth|identical protein binding|positive regulation of neuron differentiation|protein homooligomerization KCTD12 606.970716 693.9560597 519.9853722 0.749305903 -0.416373277 0.112357098 1 5.943694346 4.379119539 115207 potassium channel tetramerization domain containing 12 "GO:0003723,GO:0005515,GO:0042734,GO:0042802,GO:0042995,GO:0045211,GO:0051260" RNA binding|protein binding|presynaptic membrane|identical protein binding|cell projection|postsynaptic membrane|protein homooligomerization KCTD13 406.2343889 432.8121752 379.6566026 0.877185589 -0.189045985 0.515009709 1 4.851583767 4.184525327 253980 potassium channel tetramerization domain containing 13 "GO:0004842,GO:0005515,GO:0005654,GO:0016477,GO:0016567,GO:0016604,GO:0019904,GO:0031267,GO:0031463,GO:0035024,GO:0042802,GO:0043149,GO:0043161,GO:0045740,GO:0050806,GO:0051260,GO:0061351" ubiquitin-protein transferase activity|protein binding|nucleoplasm|cell migration|protein ubiquitination|nuclear body|protein domain specific binding|small GTPase binding|Cul3-RING ubiquitin ligase complex|negative regulation of Rho protein signal transduction|identical protein binding|stress fiber assembly|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of DNA replication|positive regulation of synaptic transmission|protein homooligomerization|neural precursor cell proliferation KCTD15 13.04983291 14.56579436 11.53387147 0.791846376 -0.336707531 0.803835859 1 0.131598049 0.102461701 79047 potassium channel tetramerization domain containing 15 "GO:0005515,GO:0007275,GO:0042802,GO:0051260" protein binding|multicellular organism development|identical protein binding|protein homooligomerization KCTD16 24.30127123 19.76786377 28.83467868 1.458664376 0.544647972 0.511132142 1 0.062042729 0.088985131 57528 potassium channel tetramerization domain containing 16 "GO:0005515,GO:0008277,GO:0042734,GO:0042995,GO:0043235,GO:0045211,GO:0051260" protein binding|regulation of G protein-coupled receptor signaling pathway|presynaptic membrane|cell projection|receptor complex|postsynaptic membrane|protein homooligomerization KCTD17 375.6711271 349.5790646 401.7631896 1.149277032 0.200726599 0.498856276 1 10.49881383 11.86413666 79734 potassium channel tetramerization domain containing 17 "GO:0005515,GO:0005737,GO:0005783,GO:0030030,GO:0031463,GO:0032469,GO:0042802,GO:0043161,GO:0045724,GO:0051260,GO:0097602" protein binding|cytoplasm|endoplasmic reticulum|cell projection organization|Cul3-RING ubiquitin ligase complex|endoplasmic reticulum calcium ion homeostasis|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of cilium assembly|protein homooligomerization|cullin family protein binding KCTD18 436.773113 477.5499721 395.9962539 0.829224745 -0.270164926 0.340189283 1 8.671644884 7.07041518 130535 potassium channel tetramerization domain containing 18 GO:0051260 protein homooligomerization KCTD2 1155.739234 1020.646019 1290.832449 1.264720995 0.338819153 0.163020301 1 14.89472304 18.52244607 23510 potassium channel tetramerization domain containing 2 "GO:0005737,GO:0031463,GO:0043161,GO:0044877,GO:0051260,GO:0097602" cytoplasm|Cul3-RING ubiquitin ligase complex|proteasome-mediated ubiquitin-dependent protein catabolic process|protein-containing complex binding|protein homooligomerization|cullin family protein binding KCTD20 912.9303113 714.7643374 1111.096285 1.554493176 0.636444284 0.010402482 0.610531935 6.418586405 9.810686328 222658 potassium channel tetramerization domain containing 20 "GO:0005737,GO:0042327,GO:0042802" cytoplasm|positive regulation of phosphorylation|identical protein binding KCTD21 278.624558 274.669265 282.5798511 1.028800405 0.040963116 0.910651607 1 1.790909451 1.81165682 283219 potassium channel tetramerization domain containing 21 "GO:0005515,GO:0006511,GO:0016567,GO:0040008,GO:0042802,GO:0042826,GO:0045879,GO:0051260,GO:0097602" protein binding|ubiquitin-dependent protein catabolic process|protein ubiquitination|regulation of growth|identical protein binding|histone deacetylase binding|negative regulation of smoothened signaling pathway|protein homooligomerization|cullin family protein binding KCTD3 1843.089161 1907.078647 1779.099675 0.932892661 -0.100217001 0.673698336 1 24.87833838 22.82045115 51133 potassium channel tetramerization domain containing 3 "GO:0005886,GO:0051260" plasma membrane|protein homooligomerization KCTD4 3.443303773 2.080827765 4.80577978 2.309551929 1.207612985 0.648665767 1 0.052283406 0.118730632 386618 potassium channel tetramerization domain containing 4 "GO:0005515,GO:0051260" protein binding|protein homooligomerization KCTD5 1155.015852 1026.888502 1283.143201 1.249544813 0.321402642 0.185790129 1 22.51567462 27.66355427 54442 potassium channel tetramerization domain containing 5 "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0016032,GO:0031463,GO:0042802,GO:0043161,GO:0044877,GO:0051260,GO:0097602" protein binding|nucleus|cytoplasm|cytosol|viral process|Cul3-RING ubiquitin ligase complex|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein-containing complex binding|protein homooligomerization|cullin family protein binding KCTD6 152.6841741 147.7387713 157.6295768 1.066947934 0.093489775 0.83142897 1 2.379881284 2.496719187 200845 potassium channel tetramerization domain containing 6 "GO:0005515,GO:0005829,GO:0006511,GO:0016567,GO:0030506,GO:0031430,GO:0033146,GO:0040008,GO:0042802,GO:0043687,GO:0045879,GO:0051260,GO:0097602" protein binding|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|ankyrin binding|M band|regulation of intracellular estrogen receptor signaling pathway|regulation of growth|identical protein binding|post-translational protein modification|negative regulation of smoothened signaling pathway|protein homooligomerization|cullin family protein binding KCTD7 233.5445773 239.295193 227.7939616 0.951937056 -0.071061912 0.84758703 1 2.52835966 2.366564057 154881 potassium channel tetramerization domain containing 7 "GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0032411,GO:0043687,GO:0051260,GO:0060081,GO:0090461" protein binding|cytoplasm|cytosol|plasma membrane|positive regulation of transporter activity|post-translational protein modification|protein homooligomerization|membrane hyperpolarization|glutamate homeostasis KCTD9 1110.331546 1102.838716 1117.824377 1.013588262 0.019471722 0.940248836 1 17.48039065 17.4214334 54793 potassium channel tetramerization domain containing 9 "GO:0005515,GO:0016567,GO:0035556,GO:0042802,GO:0043621,GO:0051260,GO:0097602" protein binding|protein ubiquitination|intracellular signal transduction|identical protein binding|protein self-association|protein homooligomerization|cullin family protein binding KDELR1 3692.071632 3401.112982 3983.030282 1.171096139 0.227859516 0.337740256 1 117.103967 134.8451514 10945 KDEL endoplasmic reticulum protein retention receptor 1 "GO:0000139,GO:0005046,GO:0005515,GO:0005783,GO:0005789,GO:0005793,GO:0005801,GO:0006621,GO:0006888,GO:0006890,GO:0015031,GO:0016021,GO:0030133,GO:0030663,GO:0033116,GO:0046923" "Golgi membrane|KDEL sequence binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|cis-Golgi network|protein retention in ER lumen|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|protein transport|integral component of membrane|transport vesicle|COPI-coated vesicle membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|ER retention sequence binding" hsa05110 Vibrio cholerae infection KDELR2 6349.309693 6079.138316 6619.481069 1.08888476 0.122851278 0.613305825 1 116.4509831 124.6798461 11014 KDEL endoplasmic reticulum protein retention receptor 2 "GO:0000139,GO:0005046,GO:0005783,GO:0005789,GO:0005801,GO:0006621,GO:0006888,GO:0006890,GO:0015031,GO:0016021,GO:0030133,GO:0030663,GO:0046923" "Golgi membrane|KDEL sequence binding|endoplasmic reticulum|endoplasmic reticulum membrane|cis-Golgi network|protein retention in ER lumen|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|protein transport|integral component of membrane|transport vesicle|COPI-coated vesicle membrane|ER retention sequence binding" hsa05110 Vibrio cholerae infection KDELR3 1460.646511 1367.103842 1554.189181 1.136847936 0.185039293 0.439463843 1 39.1205466 43.72989861 11015 KDEL endoplasmic reticulum protein retention receptor 3 "GO:0000139,GO:0005046,GO:0005783,GO:0005789,GO:0005801,GO:0006621,GO:0006888,GO:0006890,GO:0015031,GO:0016021,GO:0030133,GO:0030663,GO:0036498,GO:0046923" "Golgi membrane|KDEL sequence binding|endoplasmic reticulum|endoplasmic reticulum membrane|cis-Golgi network|protein retention in ER lumen|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|protein transport|integral component of membrane|transport vesicle|COPI-coated vesicle membrane|IRE1-mediated unfolded protein response|ER retention sequence binding" hsa05110 Vibrio cholerae infection KDM1A 2315.054521 2210.879501 2419.229541 1.094238533 0.129927265 0.583321822 1 30.58335291 32.90548368 23028 lysine demethylase 1A "GO:0000122,GO:0000380,GO:0000781,GO:0000785,GO:0001085,GO:0002039,GO:0002052,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0006482,GO:0007596,GO:0008134,GO:0010569,GO:0010976,GO:0016491,GO:0019899,GO:0021987,GO:0030374,GO:0032091,GO:0032451,GO:0032452,GO:0032453,GO:0032454,GO:0032991,GO:0033169,GO:0033184,GO:0034644,GO:0034648,GO:0034720,GO:0035563,GO:0042162,GO:0042551,GO:0043392,GO:0043426,GO:0043433,GO:0043518,GO:0045793,GO:0045892,GO:0045944,GO:0046098,GO:0050660,GO:0050681,GO:0051091,GO:0051572,GO:0051573,GO:0055001,GO:0055114,GO:0060992,GO:0061752,GO:0071320,GO:0071480,GO:0120162,GO:1902166,GO:1903827,GO:1990391,GO:1990841,GO:2000179,GO:2000648" "negative regulation of transcription by RNA polymerase II|alternative mRNA splicing, via spliceosome|chromosome, telomeric region|chromatin|RNA polymerase II transcription factor binding|p53 binding|positive regulation of neuroblast proliferation|chromatin binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|protein demethylation|blood coagulation|transcription factor binding|regulation of double-strand break repair via homologous recombination|positive regulation of neuron projection development|oxidoreductase activity|enzyme binding|cerebral cortex development|nuclear receptor coactivator activity|negative regulation of protein binding|demethylase activity|histone demethylase activity|histone demethylase activity (H3-K4 specific)|histone demethylase activity (H3-K9 specific)|protein-containing complex|histone H3-K9 demethylation|positive regulation of histone ubiquitination|cellular response to UV|histone demethylase activity (H3-dimethyl-K4 specific)|histone H3-K4 demethylation|positive regulation of chromatin binding|telomeric DNA binding|neuron maturation|negative regulation of DNA binding|MRF binding|negative regulation of DNA-binding transcription factor activity|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of cell size|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|guanine metabolic process|flavin adenine dinucleotide binding|androgen receptor binding|positive regulation of DNA-binding transcription factor activity|negative regulation of histone H3-K4 methylation|negative regulation of histone H3-K9 methylation|muscle cell development|oxidation-reduction process|response to fungicide|telomeric repeat-containing RNA binding|cellular response to cAMP|cellular response to gamma radiation|positive regulation of cold-induced thermogenesis|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of cellular protein localization|DNA repair complex|promoter-specific chromatin binding|positive regulation of neural precursor cell proliferation|positive regulation of stem cell proliferation" hsa04714 Thermogenesis other KDM1B 654.0969259 719.9664068 588.2274451 0.817020683 -0.291555495 0.26055829 1 8.352887802 6.710283627 221656 lysine demethylase 1B "GO:0000122,GO:0000786,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006349,GO:0007275,GO:0008134,GO:0008270,GO:0016491,GO:0016579,GO:0034648,GO:0034649,GO:0034720,GO:0042393,GO:0044030,GO:0045944,GO:0050660,GO:0055114,GO:0071949" negative regulation of transcription by RNA polymerase II|nucleosome|chromatin binding|protein binding|nucleus|nucleoplasm|regulation of gene expression by genetic imprinting|multicellular organism development|transcription factor binding|zinc ion binding|oxidoreductase activity|protein deubiquitination|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|histone H3-K4 demethylation|histone binding|regulation of DNA methylation|positive regulation of transcription by RNA polymerase II|flavin adenine dinucleotide binding|oxidation-reduction process|FAD binding KDM2A 2377.418989 2485.548766 2269.289212 0.912993237 -0.131323922 0.579194052 1 16.42510765 14.74507424 22992 lysine demethylase 2A "GO:0003712,GO:0005515,GO:0005654,GO:0006303,GO:0006357,GO:0006482,GO:0008270,GO:0010944,GO:0032452,GO:0032922,GO:0042752,GO:0045322,GO:0051864,GO:0055114,GO:0070544" transcription coregulator activity|protein binding|nucleoplasm|double-strand break repair via nonhomologous end joining|regulation of transcription by RNA polymerase II|protein demethylation|zinc ion binding|negative regulation of transcription by competitive promoter binding|histone demethylase activity|circadian regulation of gene expression|regulation of circadian rhythm|unmethylated CpG binding|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|histone H3-K36 demethylation KDM2B 947.8817128 1039.373469 856.3899568 0.823948256 -0.279374356 0.258313375 1 6.919841784 5.606183155 84678 lysine demethylase 2B "GO:0000122,GO:0000978,GO:0003677,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0006482,GO:0007283,GO:0008270,GO:0019843,GO:0021555,GO:0021592,GO:0021670,GO:0021678,GO:0021993,GO:0030307,GO:0030900,GO:0030901,GO:0030902,GO:0031519,GO:0032452,GO:0035518,GO:0043524,GO:0045322,GO:0048596,GO:0051864,GO:0055114,GO:0070544,GO:1902459,GO:2000178" negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA binding|transcription coregulator activity|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|protein demethylation|spermatogenesis|zinc ion binding|rRNA binding|midbrain-hindbrain boundary morphogenesis|fourth ventricle development|lateral ventricle development|third ventricle development|initiation of neural tube closure|positive regulation of cell growth|forebrain development|midbrain development|hindbrain development|PcG protein complex|histone demethylase activity|histone H2A monoubiquitination|negative regulation of neuron apoptotic process|unmethylated CpG binding|embryonic camera-type eye morphogenesis|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|histone H3-K36 demethylation|positive regulation of stem cell population maintenance|negative regulation of neural precursor cell proliferation other KDM3A 1449.8159 1410.801225 1488.830576 1.055308536 0.077664856 0.747424476 1 14.56040774 15.10859803 55818 lysine demethylase 3A "GO:0000118,GO:0000785,GO:0003712,GO:0005506,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007290,GO:0009755,GO:0016020,GO:0030521,GO:0031490,GO:0032454,GO:0033169,GO:0036123,GO:0045893,GO:0045944,GO:0046293,GO:0050681,GO:0051213,GO:0051573,GO:0055114,GO:0120162,GO:1990830,GO:2000036,GO:2000736" "histone deacetylase complex|chromatin|transcription coregulator activity|iron ion binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|spermatid nucleus elongation|hormone-mediated signaling pathway|membrane|androgen receptor signaling pathway|chromatin DNA binding|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|histone H3-K9 dimethylation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|formaldehyde biosynthetic process|androgen receptor binding|dioxygenase activity|negative regulation of histone H3-K9 methylation|oxidation-reduction process|positive regulation of cold-induced thermogenesis|cellular response to leukemia inhibitory factor|regulation of stem cell population maintenance|regulation of stem cell differentiation" hsa04714 Thermogenesis KDM3B 2192.268134 2406.477311 1978.058957 0.821972827 -0.282837394 0.231575066 1 16.66397705 13.46812995 51780 lysine demethylase 3B "GO:0000118,GO:0000785,GO:0003712,GO:0005654,GO:0006357,GO:0016209,GO:0031490,GO:0032454,GO:0033169,GO:0046872,GO:0051213,GO:0055114,GO:0072718,GO:0098869" histone deacetylase complex|chromatin|transcription coregulator activity|nucleoplasm|regulation of transcription by RNA polymerase II|antioxidant activity|chromatin DNA binding|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|metal ion binding|dioxygenase activity|oxidation-reduction process|response to cisplatin|cellular oxidant detoxification hsa04714 Thermogenesis KDM4A 1226.917037 1387.912119 1065.921955 0.768003925 -0.380814411 0.115068296 1 15.78987826 11.92376477 9682 lysine demethylase 4A "GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006338,GO:0008270,GO:0010507,GO:0010629,GO:0016032,GO:0016577,GO:0031625,GO:0032452,GO:0032454,GO:0033169,GO:0035064,GO:0035097,GO:0045892,GO:0051864,GO:0055114,GO:0070544" "fibrillar center|protein binding|nucleus|nucleoplasm|cytosol|chromatin remodeling|zinc ion binding|negative regulation of autophagy|negative regulation of gene expression|viral process|histone demethylation|ubiquitin protein ligase binding|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|methylated histone binding|histone methyltransferase complex|negative regulation of transcription, DNA-templated|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|histone H3-K36 demethylation" chromosome_remodelling_factor KDM4B 521.4536023 530.6110801 512.2961245 0.965483277 -0.050676824 0.858225967 1 3.171789665 3.011066271 23030 lysine demethylase 4B "GO:0005654,GO:0006338,GO:0032452,GO:0032454,GO:0033169,GO:0035097,GO:0046872,GO:0051864,GO:0055114,GO:0070544" nucleoplasm|chromatin remodeling|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|histone methyltransferase complex|metal ion binding|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|histone H3-K36 demethylation KDM4C 369.1065817 341.2557535 396.9574098 1.163225545 0.218130857 0.464056127 1 1.562741751 1.78740235 23081 lysine demethylase 4C "GO:0000785,GO:0003682,GO:0005654,GO:0006338,GO:0006357,GO:0008270,GO:0008284,GO:0010628,GO:0019899,GO:0032452,GO:0032454,GO:0033169,GO:0035097,GO:0045666,GO:0050681,GO:0051864,GO:0055114,GO:0070544" chromatin|chromatin binding|nucleoplasm|chromatin remodeling|regulation of transcription by RNA polymerase II|zinc ion binding|positive regulation of cell population proliferation|positive regulation of gene expression|enzyme binding|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|histone methyltransferase complex|positive regulation of neuron differentiation|androgen receptor binding|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|histone H3-K36 demethylation other KDM4D 68.29114829 76.99062732 59.59166927 0.774011998 -0.369572165 0.500359731 1 1.392357939 1.059667871 55693 lysine demethylase 4D "GO:0000724,GO:0001932,GO:0003684,GO:0005515,GO:0005654,GO:0005721,GO:0006338,GO:0031490,GO:0032452,GO:0032454,GO:0033169,GO:0035097,GO:0035563,GO:0035861,GO:0046872,GO:0051213,GO:0055114,GO:0071479,GO:0072562,GO:1900113,GO:2001034" double-strand break repair via homologous recombination|regulation of protein phosphorylation|damaged DNA binding|protein binding|nucleoplasm|pericentric heterochromatin|chromatin remodeling|chromatin DNA binding|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|histone methyltransferase complex|positive regulation of chromatin binding|site of double-strand break|metal ion binding|dioxygenase activity|oxidation-reduction process|cellular response to ionizing radiation|blood microparticle|negative regulation of histone H3-K9 trimethylation|positive regulation of double-strand break repair via nonhomologous end joining KDM5A 1770.31994 1712.521251 1828.118628 1.067501281 0.094237801 0.692665803 1 8.540707567 8.964651998 5927 lysine demethylase 5A "GO:0000976,GO:0003677,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006338,GO:0007283,GO:0008270,GO:0008584,GO:0032452,GO:0032922,GO:0034647,GO:0034648,GO:0034720,GO:0034721,GO:0035064,GO:0035097,GO:0042393,GO:0045893,GO:0051090,GO:0051213,GO:0055114,GO:1901726" "transcription regulatory region sequence-specific DNA binding|DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|nucleolus|chromatin remodeling|spermatogenesis|zinc ion binding|male gonad development|histone demethylase activity|circadian regulation of gene expression|histone demethylase activity (H3-trimethyl-K4 specific)|histone demethylase activity (H3-dimethyl-K4 specific)|histone H3-K4 demethylation|histone H3-K4 demethylation, trimethyl-H3-K4-specific|methylated histone binding|histone methyltransferase complex|histone binding|positive regulation of transcription, DNA-templated|regulation of DNA-binding transcription factor activity|dioxygenase activity|oxidation-reduction process|negative regulation of histone deacetylase activity" ARID KDM5B 2267.504412 2640.570434 1894.438389 0.71743528 -0.479079403 0.042838261 1 12.99063338 9.163982146 10765 lysine demethylase 5B "GO:0003677,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006338,GO:0006357,GO:0007338,GO:0008270,GO:0009791,GO:0010628,GO:0032452,GO:0032453,GO:0033601,GO:0034647,GO:0034648,GO:0034720,GO:0034721,GO:0035097,GO:0042393,GO:0044344,GO:0045892,GO:0048511,GO:0051213,GO:0055114,GO:0060444,GO:0060763,GO:0060992,GO:0061038,GO:0070306,GO:1990830,GO:1990837,GO:2000864" "DNA binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytosol|chromatin remodeling|regulation of transcription by RNA polymerase II|single fertilization|zinc ion binding|post-embryonic development|positive regulation of gene expression|histone demethylase activity|histone demethylase activity (H3-K4 specific)|positive regulation of mammary gland epithelial cell proliferation|histone demethylase activity (H3-trimethyl-K4 specific)|histone demethylase activity (H3-dimethyl-K4 specific)|histone H3-K4 demethylation|histone H3-K4 demethylation, trimethyl-H3-K4-specific|histone methyltransferase complex|histone binding|cellular response to fibroblast growth factor stimulus|negative regulation of transcription, DNA-templated|rhythmic process|dioxygenase activity|oxidation-reduction process|branching involved in mammary gland duct morphogenesis|mammary duct terminal end bud growth|response to fungicide|uterus morphogenesis|lens fiber cell differentiation|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding|regulation of estradiol secretion" ARID KDM5C 4270.593284 4231.363261 4309.823307 1.018542498 0.026506177 0.912521704 1 34.96749463 35.01989583 8242 lysine demethylase 5C "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006338,GO:0008270,GO:0009636,GO:0032452,GO:0032453,GO:0034647,GO:0034720,GO:0034721,GO:0035097,GO:0045892,GO:0048511,GO:0051213,GO:0055114" "DNA binding|protein binding|nucleus|nucleoplasm|cytosol|chromatin remodeling|zinc ion binding|response to toxic substance|histone demethylase activity|histone demethylase activity (H3-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|histone H3-K4 demethylation|histone H3-K4 demethylation, trimethyl-H3-K4-specific|histone methyltransferase complex|negative regulation of transcription, DNA-templated|rhythmic process|dioxygenase activity|oxidation-reduction process" ARID KDM6A 512.0301268 560.7830827 463.2771708 0.82612544 -0.275567236 0.311520181 1 4.7762468 3.87975172 7403 lysine demethylase 6A "GO:0000978,GO:0005515,GO:0005634,GO:0005654,GO:0006338,GO:0007507,GO:0010468,GO:0031490,GO:0035097,GO:0044666,GO:0046872,GO:0051213,GO:0051568,GO:0055114,GO:0071557,GO:0071558" RNA polymerase II cis-regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|chromatin remodeling|heart development|regulation of gene expression|chromatin DNA binding|histone methyltransferase complex|MLL3/4 complex|metal ion binding|dioxygenase activity|histone H3-K4 methylation|oxidation-reduction process|histone H3-K27 demethylation|histone demethylase activity (H3-K27 specific) hsa05202 Transcriptional misregulation in cancer KDM6B 606.1334773 684.5923348 527.6746198 0.770786632 -0.375596545 0.152284814 1 3.800627762 2.880452307 23135 lysine demethylase 6B "GO:0000978,GO:0002437,GO:0005515,GO:0005634,GO:0005654,GO:0006338,GO:0007507,GO:0008013,GO:0010468,GO:0014823,GO:0021766,GO:0031490,GO:0044666,GO:0045165,GO:0045446,GO:0045944,GO:0046872,GO:0048333,GO:0051213,GO:0055007,GO:0055114,GO:0060992,GO:0070301,GO:0071557,GO:0071558,GO:0120162" RNA polymerase II cis-regulatory region sequence-specific DNA binding|inflammatory response to antigenic stimulus|protein binding|nucleus|nucleoplasm|chromatin remodeling|heart development|beta-catenin binding|regulation of gene expression|response to activity|hippocampus development|chromatin DNA binding|MLL3/4 complex|cell fate commitment|endothelial cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|mesodermal cell differentiation|dioxygenase activity|cardiac muscle cell differentiation|oxidation-reduction process|response to fungicide|cellular response to hydrogen peroxide|histone H3-K27 demethylation|histone demethylase activity (H3-K27 specific)|positive regulation of cold-induced thermogenesis KDM7A 451.8987433 508.7623886 395.0350979 0.776462857 -0.365011181 0.192530584 1 2.964808213 2.263541542 80853 lysine demethylase 7A "GO:0003712,GO:0005506,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0006482,GO:0008270,GO:0016706,GO:0030901,GO:0032452,GO:0032454,GO:0033169,GO:0035064,GO:0035574,GO:0035575,GO:0045893,GO:0051864,GO:0055114,GO:0070544,GO:0071557,GO:0071558" "transcription coregulator activity|iron ion binding|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|protein demethylation|zinc ion binding|2-oxoglutarate-dependent dioxygenase activity|midbrain development|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|methylated histone binding|histone H4-K20 demethylation|histone demethylase activity (H4-K20 specific)|positive regulation of transcription, DNA-templated|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|histone H3-K36 demethylation|histone H3-K27 demethylation|histone demethylase activity (H3-K27 specific)" KDM8 34.26446104 41.61655531 26.91236677 0.64667454 -0.628888283 0.370428575 1 0.676103217 0.429902474 79831 lysine demethylase 8 "GO:0000086,GO:0003682,GO:0004175,GO:0004177,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006508,GO:0016706,GO:0031648,GO:0032922,GO:0035064,GO:0045892,GO:0045893,GO:0046872,GO:0051864,GO:0055114,GO:0070544,GO:0140554" "G2/M transition of mitotic cell cycle|chromatin binding|endopeptidase activity|aminopeptidase activity|protein binding|nucleus|nucleoplasm|chromosome|cytosol|proteolysis|2-oxoglutarate-dependent dioxygenase activity|protein destabilization|circadian regulation of gene expression|methylated histone binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|histone H3-K36 demethylation|L-arginine 3-hydroxylase activity" KDR 9.888962303 7.282897178 12.49502743 1.715667148 0.778769686 0.540720238 1 0.06663378 0.112408373 3791 kinase insert domain receptor "GO:0001525,GO:0001569,GO:0001570,GO:0001934,GO:0001938,GO:0002042,GO:0002244,GO:0003158,GO:0004713,GO:0004714,GO:0005021,GO:0005178,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005768,GO:0005769,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0007169,GO:0007275,GO:0008284,GO:0008360,GO:0010595,GO:0010629,GO:0014068,GO:0016032,GO:0016239,GO:0016477,GO:0018108,GO:0019838,GO:0030054,GO:0030198,GO:0030335,GO:0033674,GO:0035162,GO:0035584,GO:0035924,GO:0036324,GO:0038033,GO:0038083,GO:0038084,GO:0038085,GO:0042802,GO:0043066,GO:0043235,GO:0043410,GO:0043491,GO:0043536,GO:0045121,GO:0045296,GO:0045446,GO:0045766,GO:0046777,GO:0048010,GO:0050927,GO:0051770,GO:0051879,GO:0051894,GO:0051901,GO:0061042,GO:0070371,GO:0070374,GO:0090050,GO:0090141,GO:0097443,GO:1904881,GO:2000352,GO:2001214" angiogenesis|branching involved in blood vessel morphogenesis|vasculogenesis|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|cell migration involved in sprouting angiogenesis|hematopoietic progenitor cell differentiation|endothelium development|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|vascular endothelial growth factor-activated receptor activity|integrin binding|protein binding|ATP binding|extracellular region|nucleus|endosome|early endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|positive regulation of cell population proliferation|regulation of cell shape|positive regulation of endothelial cell migration|negative regulation of gene expression|positive regulation of phosphatidylinositol 3-kinase signaling|viral process|positive regulation of macroautophagy|cell migration|peptidyl-tyrosine phosphorylation|growth factor binding|cell junction|extracellular matrix organization|positive regulation of cell migration|positive regulation of kinase activity|embryonic hemopoiesis|calcium-mediated signaling using intracellular calcium source|cellular response to vascular endothelial growth factor stimulus|vascular endothelial growth factor receptor-2 signaling pathway|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway|peptidyl-tyrosine autophosphorylation|vascular endothelial growth factor signaling pathway|vascular endothelial growth factor binding|identical protein binding|negative regulation of apoptotic process|receptor complex|positive regulation of MAPK cascade|protein kinase B signaling|positive regulation of blood vessel endothelial cell migration|membrane raft|cadherin binding|endothelial cell differentiation|positive regulation of angiogenesis|protein autophosphorylation|vascular endothelial growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of nitric-oxide synthase biosynthetic process|Hsp90 protein binding|positive regulation of focal adhesion assembly|positive regulation of mitochondrial depolarization|vascular wound healing|ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of mitochondrial fission|sorting endosome|cellular response to hydrogen sulfide|negative regulation of endothelial cell apoptotic process|positive regulation of vasculogenesis "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04370,hsa04510,hsa05205,hsa05418" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|VEGF signaling pathway|Focal adhesion|Proteoglycans in cancer|Fluid shear stress and atherosclerosis KDSR 2404.242651 2407.517724 2400.967578 0.997279295 -0.003930497 0.988724215 1 22.78907345 22.34676434 2531 3-ketodihydrosphingosine reductase "GO:0005515,GO:0005615,GO:0005783,GO:0005789,GO:0006666,GO:0016020,GO:0016021,GO:0030148,GO:0047560,GO:0055114" protein binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum membrane|3-keto-sphinganine metabolic process|membrane|integral component of membrane|sphingolipid biosynthetic process|3-dehydrosphinganine reductase activity|oxidation-reduction process hsa00600 Sphingolipid metabolism KEAP1 796.5801364 839.6140033 753.5462695 0.897491307 -0.156030129 0.537516898 1 14.77858054 13.04169839 9817 kelch like ECH associated protein 1 "GO:0001701,GO:0005515,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0005884,GO:0006511,GO:0008134,GO:0010506,GO:0016032,GO:0016234,GO:0016567,GO:0016579,GO:0030496,GO:0031463,GO:0032436,GO:0034451,GO:0034599,GO:0042802,GO:0042994,GO:0043433,GO:0043687,GO:0045604,GO:0071353,GO:0097718" in utero embryonic development|protein binding|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|actin filament|ubiquitin-dependent protein catabolic process|transcription factor binding|regulation of autophagy|viral process|inclusion body|protein ubiquitination|protein deubiquitination|midbody|Cul3-RING ubiquitin ligase complex|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|centriolar satellite|cellular response to oxidative stress|identical protein binding|cytoplasmic sequestering of transcription factor|negative regulation of DNA-binding transcription factor activity|post-translational protein modification|regulation of epidermal cell differentiation|cellular response to interleukin-4|disordered domain specific binding "hsa04120,hsa05200,hsa05225,hsa05418" Ubiquitin mediated proteolysis|Pathways in cancer|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis KHDC1 78.85883339 89.47559391 68.24207288 0.762689242 -0.390832745 0.449884959 1 2.657288813 1.992771752 80759 KH domain containing 1 "GO:0003723,GO:0005737,GO:0006919,GO:0016021" RNA binding|cytoplasm|activation of cysteine-type endopeptidase activity involved in apoptotic process|integral component of membrane KHDC4 1471.778448 1470.104816 1473.452081 1.002276888 0.003281121 0.992296668 1 26.49672141 26.11265519 22889 "KH domain containing 4, pre-mRNA splicing factor" "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0006376" RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|mRNA splice site selection KHDRBS1 4933.663904 4745.327719 5122.000089 1.079377525 0.110199553 0.646361248 1 93.34663428 99.07023956 10657 "KH RNA binding domain containing, signal transduction associated 1" "GO:0000082,GO:0000086,GO:0000122,GO:0000381,GO:0003677,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006397,GO:0007283,GO:0008143,GO:0008266,GO:0016020,GO:0017124,GO:0019904,GO:0031647,GO:0032991,GO:0035591,GO:0042169,GO:0042802,GO:0044877,GO:0045892,GO:0045948,GO:0046831,GO:0046833,GO:0048024,GO:0050852,GO:0070618,GO:1990782" "G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|regulation of alternative mRNA splicing, via spliceosome|DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|mRNA processing|spermatogenesis|poly(A) binding|poly(U) RNA binding|membrane|SH3 domain binding|protein domain specific binding|regulation of protein stability|protein-containing complex|signaling adaptor activity|SH2 domain binding|identical protein binding|protein-containing complex binding|negative regulation of transcription, DNA-templated|positive regulation of translational initiation|regulation of RNA export from nucleus|positive regulation of RNA export from nucleus|regulation of mRNA splicing, via spliceosome|T cell receptor signaling pathway|Grb2-Sos complex|protein tyrosine kinase binding" KHDRBS3 140.1992075 122.7688382 157.6295768 1.283954293 0.360593845 0.390209868 1 1.779453355 2.246504798 10656 "KH RNA binding domain containing, signal transduction associated 3" "GO:0000381,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0006397,GO:0016032,GO:0017124,GO:0019904,GO:0032991,GO:0042802,GO:0048024" "regulation of alternative mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|mRNA processing|viral process|SH3 domain binding|protein domain specific binding|protein-containing complex|identical protein binding|regulation of mRNA splicing, via spliceosome" KHK 123.9784431 125.8900798 122.0668064 0.969630066 -0.04449366 0.93814271 1 2.016968533 1.922987118 3795 ketohexokinase "GO:0004454,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006000,GO:0009744,GO:0009749,GO:0009750,GO:0010043,GO:0032868,GO:0046835,GO:0061624,GO:0070062,GO:0070873" ketohexokinase activity|protein binding|ATP binding|cytoplasm|cytosol|fructose metabolic process|response to sucrose|response to glucose|response to fructose|response to zinc ion|response to insulin|carbohydrate phosphorylation|fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate|extracellular exosome|regulation of glycogen metabolic process hsa00051 Fructose and mannose metabolism KHNYN 2121.194126 2079.787351 2162.600901 1.039818277 0.056331419 0.813381473 1 15.637423 15.98798786 23351 KH and NYN domain containing "GO:0003674,GO:0003729,GO:0004521,GO:0005515,GO:0005575,GO:0005634,GO:0008150,GO:0036464,GO:0090502" "molecular_function|mRNA binding|endoribonuclease activity|protein binding|cellular_component|nucleus|biological_process|cytoplasmic ribonucleoprotein granule|RNA phosphodiester bond hydrolysis, endonucleolytic" KHSRP 2718.196008 2865.299833 2571.092182 0.897320466 -0.156304778 0.50908322 1 35.76140923 31.55247102 8570 KH-type splicing regulatory protein "GO:0000178,GO:0000375,GO:0003677,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006397,GO:0008380,GO:0010468,GO:0010586,GO:0010989,GO:0016020,GO:0035925,GO:0043488,GO:0045019,GO:0051028,GO:0061014,GO:0061158,GO:0071345" "exosome (RNase complex)|RNA splicing, via transesterification reactions|DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|mRNA processing|RNA splicing|regulation of gene expression|miRNA metabolic process|negative regulation of low-density lipoprotein particle clearance|membrane|mRNA 3'-UTR AU-rich region binding|regulation of mRNA stability|negative regulation of nitric oxide biosynthetic process|mRNA transport|positive regulation of mRNA catabolic process|3'-UTR-mediated mRNA destabilization|cellular response to cytokine stimulus" KIAA0040 4.003139677 4.161655531 3.844623824 0.923820772 -0.11431511 1 1 0.046748033 0.042464132 9674 KIAA0040 GO:0016021 integral component of membrane KIAA0100 4996.532259 5260.332591 4732.731927 0.899702033 -0.152480812 0.525452403 1 35.39262258 31.30996812 9703 KIAA0100 GO:0005576 extracellular region KIAA0232 1104.836983 1122.606579 1087.067386 0.968342255 -0.046411045 0.852414363 1 7.014570879 6.678842002 9778 KIAA0232 GO:0005524 ATP binding KIAA0319 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.019827988 0.006003663 9856 KIAA0319 "GO:0001764,GO:0005515,GO:0005769,GO:0005886,GO:0010996,GO:0016021,GO:0030517,GO:0030665,GO:0031410,GO:0031901,GO:0033555,GO:0043231,GO:0048692,GO:0060391,GO:0061024,GO:2000171" neuron migration|protein binding|early endosome|plasma membrane|response to auditory stimulus|integral component of membrane|negative regulation of axon extension|clathrin-coated vesicle membrane|cytoplasmic vesicle|early endosome membrane|multicellular organismal response to stress|intracellular membrane-bounded organelle|negative regulation of axon extension involved in regeneration|positive regulation of SMAD protein signal transduction|membrane organization|negative regulation of dendrite development KIAA0319L 1129.94531 1226.647968 1033.242653 0.84233022 -0.247542168 0.309220711 1 8.217919602 6.806368352 79932 KIAA0319 like "GO:0000139,GO:0005515,GO:0005730,GO:0005794,GO:0005886,GO:0016021,GO:0016032,GO:0031410" Golgi membrane|protein binding|nucleolus|Golgi apparatus|plasma membrane|integral component of membrane|viral process|cytoplasmic vesicle KIAA0513 187.5977898 168.547049 206.6485305 1.226058432 0.294027737 0.434394213 1 0.856263325 1.032261405 9764 KIAA0513 GO:0005737 cytoplasm KIAA0586 532.2685077 625.2887435 439.2482719 0.7024727 -0.509485936 0.058511483 1 3.765573348 2.600948428 9786 KIAA0586 "GO:0001917,GO:0005737,GO:0005813,GO:0005814,GO:0007224,GO:0036064,GO:0060271,GO:0070201" photoreceptor inner segment|cytoplasm|centrosome|centriole|smoothened signaling pathway|ciliary basal body|cilium assembly|regulation of establishment of protein localization KIAA0753 585.2113432 627.3695712 543.0531151 0.865603211 -0.208222245 0.432447264 1 5.194160869 4.420846476 9851 KIAA0753 "GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0007099,GO:0034451,GO:0071539" protein binding|centrosome|centriole|cytosol|centriole replication|centriolar satellite|protein localization to centrosome KIAA0754 1152.115449 1367.103842 937.1270571 0.685483449 -0.544806262 0.024978803 0.86041596 9.846129475 6.636417416 643314 KIAA0754 KIAA0825 23.85529179 33.29324424 14.41733934 0.433040987 -1.207424514 0.130217901 1 0.064837223 0.027607341 285600 KIAA0825 GO:0005515 protein binding KIAA0895 217.6163069 212.2444321 222.9881818 1.050619701 0.071240543 0.852048575 1 2.191351374 2.263751439 23366 KIAA0895 KIAA0895L 239.1580276 222.6485709 255.6674843 1.148300585 0.199500339 0.563839142 1 3.369922013 3.804929509 653319 KIAA0895 like GO:0005515 protein binding KIAA0930 1529.873049 1607.439449 1452.30665 0.903490735 -0.146418288 0.540186118 1 12.62116949 11.21229411 23313 KIAA0930 "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process KIAA1109 2921.64784 3046.331848 2796.963832 0.918141546 -0.12321151 0.603220638 1 9.027549105 8.14986993 84162 KIAA1109 "GO:0001558,GO:0005515,GO:0005634,GO:0006909,GO:0016020,GO:0016021,GO:0016197,GO:0030856,GO:0032456,GO:0048488,GO:0098793" regulation of cell growth|protein binding|nucleus|phagocytosis|membrane|integral component of membrane|endosomal transport|regulation of epithelial cell differentiation|endocytic recycling|synaptic vesicle endocytosis|presynapse KIAA1143 1385.517831 1362.942186 1408.093476 1.03312781 0.047018743 0.847226712 1 14.16784564 14.39226169 57456 KIAA1143 GO:0005515 protein binding KIAA1191 3091.462286 2722.763131 3460.161442 1.270827198 0.345767872 0.14441684 1 51.8035166 64.73168645 57179 KIAA1191 "GO:0003674,GO:0005515,GO:0005575,GO:0005737,GO:0008150,GO:0016491,GO:0055114" molecular_function|protein binding|cellular_component|cytoplasm|biological_process|oxidoreductase activity|oxidation-reduction process KIAA1217 115.5953814 158.1429102 73.04785266 0.461910386 -1.11431511 0.01259442 0.667553074 0.741503818 0.336776902 56243 KIAA1217 "GO:0003674,GO:0005737,GO:0030234,GO:0048706,GO:0050790" molecular_function|cytoplasm|enzyme regulator activity|embryonic skeletal system development|regulation of catalytic activity KIAA1328 231.7807812 243.4568485 220.1047139 0.904081012 -0.145476041 0.680849667 1 1.205496804 1.071629326 57536 KIAA1328 GO:0005515 protein binding KIAA1522 1377.322853 1425.367019 1329.278687 0.932586954 -0.100689847 0.676371077 1 12.82137504 11.75696211 57648 KIAA1522 GO:0030154 cell differentiation KIAA1549 672.1752211 778.2295842 566.1208581 0.727447105 -0.459085746 0.074814452 1 3.322083073 2.376200522 57670 KIAA1549 "GO:0005886,GO:0016021,GO:0032391" plasma membrane|integral component of membrane|photoreceptor connecting cilium KIAA1549L 2084.778412 2208.798673 1960.75815 0.887703426 -0.171850329 0.467943312 1 12.03712096 10.50658793 25758 KIAA1549 like GO:0016021 integral component of membrane KIAA1586 217.1306985 224.7293987 209.5319984 0.932374668 -0.101018287 0.785315231 1 4.214123321 3.863392964 57691 KIAA1586 "GO:0016925,GO:0061665" protein sumoylation|SUMO ligase activity KIAA1614 67.49353861 68.66731625 66.31976096 0.965812625 -0.050184772 0.955592869 1 0.368454501 0.349903207 57710 KIAA1614 "GO:0005080,GO:0005634,GO:0005938,GO:0007098,GO:0007163,GO:0016324,GO:0060341" protein kinase C binding|nucleus|cell cortex|centrosome cycle|establishment or maintenance of cell polarity|apical plasma membrane|regulation of cellular localization KIAA1671 458.988526 505.641147 412.3359051 0.815471422 -0.294293776 0.292244634 1 2.093169305 1.678356759 85379 KIAA1671 KIAA1755 10.08710712 12.48496659 7.689247648 0.615880514 -0.699277611 0.583437741 1 0.06712671 0.04065023 85449 KIAA1755 KIAA1841 347.311996 362.0640312 332.5599608 0.918511457 -0.122630378 0.690298171 1 3.489740274 3.151728957 84542 KIAA1841 KIAA1958 683.6499564 726.2088901 641.0910226 0.882791482 -0.179855385 0.486243445 1 1.50715278 1.308237494 158405 KIAA1958 GO:0005515 protein binding KIAA2013 1217.811822 1224.56714 1211.056505 0.988967011 -0.016005697 0.950895385 1 23.18300731 22.54357332 90231 KIAA2013 "GO:0005515,GO:0016020,GO:0016021" protein binding|membrane|integral component of membrane KIAA2026 572.4986636 571.1872216 573.8101057 1.004591987 0.006609672 0.987630778 1 1.802673697 1.780647729 158358 KIAA2026 KICS2 323.3327869 338.1345119 308.5310619 0.91245067 -0.132181531 0.673948135 1 3.283409285 2.945815853 144577 KICSTOR subunit 2 KIDINS220 1458.876456 1585.590757 1332.162155 0.84016771 -0.251250755 0.293259322 1 6.669298906 5.509565455 57498 kinase D interacting substrate 220 "GO:0000186,GO:0001701,GO:0005770,GO:0005829,GO:0010976,GO:0016020,GO:0016021,GO:0019887,GO:0030165,GO:0032991,GO:0038180,GO:0048813,GO:1990090" activation of MAPKK activity|in utero embryonic development|late endosome|cytosol|positive regulation of neuron projection development|membrane|integral component of membrane|protein kinase regulator activity|PDZ domain binding|protein-containing complex|nerve growth factor signaling pathway|dendrite morphogenesis|cellular response to nerve growth factor stimulus hsa04722 Neurotrophin signaling pathway KIF11 7145.890559 7612.708379 6679.072738 0.877358281 -0.188761988 0.4405997 1 80.99606352 69.87343125 3832 kinesin family member 11 "GO:0000278,GO:0000922,GO:0003777,GO:0005515,GO:0005524,GO:0005634,GO:0005819,GO:0005829,GO:0005871,GO:0005874,GO:0005876,GO:0006890,GO:0007018,GO:0007051,GO:0007052,GO:0007100,GO:0008017,GO:0008574,GO:0016020,GO:0019886,GO:0019901,GO:0032991,GO:0046602,GO:0051301,GO:0072686,GO:0090307" "mitotic cell cycle|spindle pole|microtubule motor activity|protein binding|ATP binding|nucleus|spindle|cytosol|kinesin complex|microtubule|spindle microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|spindle organization|mitotic spindle organization|mitotic centrosome separation|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|protein-containing complex|regulation of mitotic centrosome separation|cell division|mitotic spindle|mitotic spindle assembly" KIF12 26.50098588 27.05076095 25.95121081 0.95935234 -0.059867326 0.993737591 1 0.542725336 0.511952201 113220 kinesin family member 12 "GO:0003674,GO:0003777,GO:0005524,GO:0005737,GO:0005871,GO:0005874,GO:0007018,GO:0008017,GO:0008150,GO:0016887,GO:0070062" molecular_function|microtubule motor activity|ATP binding|cytoplasm|kinesin complex|microtubule|microtubule-based movement|microtubule binding|biological_process|ATPase activity|extracellular exosome KIF13A 677.5955571 743.8959261 611.295188 0.821748267 -0.283231586 0.271727054 1 4.335046774 3.50270662 63971 kinesin family member 13A "GO:0003777,GO:0005515,GO:0005524,GO:0005813,GO:0005871,GO:0005874,GO:0006886,GO:0007018,GO:0007049,GO:0008017,GO:0008333,GO:0010008,GO:0016887,GO:0030496,GO:0032438,GO:0032465,GO:0032588,GO:0035459,GO:0043001,GO:0051301,GO:0072383" microtubule motor activity|protein binding|ATP binding|centrosome|kinesin complex|microtubule|intracellular protein transport|microtubule-based movement|cell cycle|microtubule binding|endosome to lysosome transport|endosome membrane|ATPase activity|midbody|melanosome organization|regulation of cytokinesis|trans-Golgi network membrane|vesicle cargo loading|Golgi to plasma membrane protein transport|cell division|plus-end-directed vesicle transport along microtubule KIF13B 632.0651808 633.6120545 630.5183071 0.995117285 -0.007061523 0.985244942 1 3.742221206 3.661633762 23303 kinesin family member 13B "GO:0003777,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005871,GO:0005874,GO:0005902,GO:0006605,GO:0007018,GO:0007165,GO:0008017,GO:0016887,GO:0019901,GO:0030424,GO:0033270,GO:0042110,GO:0050770,GO:0071889" microtubule motor activity|protein binding|ATP binding|cytoplasm|cytosol|kinesin complex|microtubule|microvillus|protein targeting|microtubule-based movement|signal transduction|microtubule binding|ATPase activity|protein kinase binding|axon|paranode region of axon|T cell activation|regulation of axonogenesis|14-3-3 protein binding KIF14 1524.991813 1794.713948 1255.269679 0.699426045 -0.515756575 0.030654513 0.895820653 12.04484216 8.283504113 9928 kinesin family member 14 "GO:0001558,GO:0003777,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0005871,GO:0005874,GO:0005886,GO:0007018,GO:0007019,GO:0007080,GO:0008017,GO:0008284,GO:0008574,GO:0010389,GO:0015631,GO:0016020,GO:0016887,GO:0019901,GO:0021685,GO:0021693,GO:0021695,GO:0021766,GO:0021772,GO:0021846,GO:0021987,GO:0030155,GO:0030165,GO:0030334,GO:0030496,GO:0031146,GO:0031641,GO:0032147,GO:0032467,GO:0032487,GO:0033624,GO:0034446,GO:0043066,GO:0043161,GO:0043523,GO:0043524,GO:0045184,GO:0051233,GO:0051301,GO:0090543,GO:1903429,GO:2000045" "regulation of cell growth|microtubule motor activity|protein binding|ATP binding|nucleus|cytosol|kinesin complex|microtubule|plasma membrane|microtubule-based movement|microtubule depolymerization|mitotic metaphase plate congression|microtubule binding|positive regulation of cell population proliferation|ATP-dependent microtubule motor activity, plus-end-directed|regulation of G2/M transition of mitotic cell cycle|tubulin binding|membrane|ATPase activity|protein kinase binding|cerebellar granular layer structural organization|cerebellar Purkinje cell layer structural organization|cerebellar cortex development|hippocampus development|olfactory bulb development|cell proliferation in forebrain|cerebral cortex development|regulation of cell adhesion|PDZ domain binding|regulation of cell migration|midbody|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of myelination|activation of protein kinase activity|positive regulation of cytokinesis|regulation of Rap protein signal transduction|negative regulation of integrin activation|substrate adhesion-dependent cell spreading|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of neuron apoptotic process|negative regulation of neuron apoptotic process|establishment of protein localization|spindle midzone|cell division|Flemming body|regulation of cell maturation|regulation of G1/S transition of mitotic cell cycle" KIF15 1151.249257 1230.809623 1071.688891 0.870718648 -0.199721473 0.411723649 1 12.3493227 10.57285226 56992 kinesin family member 15 "GO:0000278,GO:0003774,GO:0003777,GO:0005515,GO:0005524,GO:0005813,GO:0005819,GO:0005829,GO:0005871,GO:0005873,GO:0005874,GO:0006890,GO:0007018,GO:0008017,GO:0016020,GO:0016887,GO:0019886" "mitotic cell cycle|motor activity|microtubule motor activity|protein binding|ATP binding|centrosome|spindle|cytosol|kinesin complex|plus-end kinesin complex|microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|microtubule binding|membrane|ATPase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II" KIF16B 729.7955031 701.2389569 758.3520493 1.081445978 0.112961599 0.660803368 1 4.782598634 5.085573597 55614 kinesin family member 16B "GO:0001704,GO:0001919,GO:0003777,GO:0005524,GO:0005547,GO:0005737,GO:0005768,GO:0005769,GO:0005819,GO:0005829,GO:0005871,GO:0005874,GO:0006895,GO:0007018,GO:0007173,GO:0007492,GO:0008017,GO:0008543,GO:0008574,GO:0016887,GO:0031901,GO:0032266,GO:0032801,GO:0043325,GO:0045022,GO:0080025" "formation of primary germ layer|regulation of receptor recycling|microtubule motor activity|ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|endosome|early endosome|spindle|cytosol|kinesin complex|microtubule|Golgi to endosome transport|microtubule-based movement|epidermal growth factor receptor signaling pathway|endoderm development|microtubule binding|fibroblast growth factor receptor signaling pathway|ATP-dependent microtubule motor activity, plus-end-directed|ATPase activity|early endosome membrane|phosphatidylinositol-3-phosphate binding|receptor catabolic process|phosphatidylinositol-3,4-bisphosphate binding|early endosome to late endosome transport|phosphatidylinositol-3,5-bisphosphate binding" KIF17 28.38366883 26.01034707 30.75699059 1.182490588 0.2418287 0.783858736 1 0.339560768 0.394808394 57576 kinesin family member 17 "GO:0003777,GO:0005524,GO:0005815,GO:0005829,GO:0005871,GO:0005874,GO:0005929,GO:0005930,GO:0007018,GO:0008017,GO:0008574,GO:0016192,GO:0016887,GO:0030030,GO:0032391,GO:0032839,GO:0035735,GO:0036064,GO:0043005,GO:0098971,GO:1990075" "microtubule motor activity|ATP binding|microtubule organizing center|cytosol|kinesin complex|microtubule|cilium|axoneme|microtubule-based movement|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|vesicle-mediated transport|ATPase activity|cell projection organization|photoreceptor connecting cilium|dendrite cytoplasm|intraciliary transport involved in cilium assembly|ciliary basal body|neuron projection|anterograde dendritic transport of neurotransmitter receptor complex|periciliary membrane compartment" KIF18A 1468.660394 1754.137806 1183.182982 0.674509709 -0.568088884 0.017522963 0.770503287 22.46043924 14.89627322 81930 kinesin family member 18A "GO:0000070,GO:0000776,GO:0001726,GO:0003777,GO:0003779,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005815,GO:0005828,GO:0005829,GO:0005871,GO:0005874,GO:0005901,GO:0006890,GO:0007018,GO:0007019,GO:0007080,GO:0007140,GO:0008017,GO:0008574,GO:0015031,GO:0015630,GO:0016887,GO:0019886,GO:0051010,GO:0061673,GO:0070463,GO:0070507,GO:0071392,GO:0072520,GO:1990023" "mitotic sister chromatid segregation|kinetochore|ruffle|microtubule motor activity|actin binding|protein binding|ATP binding|nucleus|cytoplasm|microtubule organizing center|kinetochore microtubule|cytosol|kinesin complex|microtubule|caveola|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|microtubule depolymerization|mitotic metaphase plate congression|male meiotic nuclear division|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|protein transport|microtubule cytoskeleton|ATPase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|microtubule plus-end binding|mitotic spindle astral microtubule|tubulin-dependent ATPase activity|regulation of microtubule cytoskeleton organization|cellular response to estradiol stimulus|seminiferous tubule development|mitotic spindle midzone" KIF18B 1235.780063 1456.579436 1014.98069 0.696824811 -0.521132102 0.03105656 0.895820653 15.46349063 10.59503314 146909 kinesin family member 18B "GO:0000070,GO:0000235,GO:0000278,GO:0003774,GO:0003777,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005871,GO:0005874,GO:0007018,GO:0007019,GO:0008017,GO:0008574,GO:0016604,GO:0016887,GO:0019894,GO:0035371,GO:0051301,GO:0051302,GO:0061673,GO:1990023,GO:1990752" "mitotic sister chromatid segregation|astral microtubule|mitotic cell cycle|motor activity|microtubule motor activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|kinesin complex|microtubule|microtubule-based movement|microtubule depolymerization|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|nuclear body|ATPase activity|kinesin binding|microtubule plus-end|cell division|regulation of cell division|mitotic spindle astral microtubule|mitotic spindle midzone|microtubule end" KIF1B 2740.436573 2830.966175 2649.906971 0.936043318 -0.095352799 0.687710424 1 9.075717045 8.353107551 23095 kinesin family member 1B "GO:0003777,GO:0005515,GO:0005524,GO:0005739,GO:0005871,GO:0005874,GO:0005875,GO:0006915,GO:0007018,GO:0007270,GO:0007274,GO:0008017,GO:0008021,GO:0008089,GO:0008574,GO:0010628,GO:0016192,GO:0016887,GO:0019894,GO:0019900,GO:0030424,GO:0030425,GO:0030659,GO:0030705,GO:0031410,GO:0032418,GO:0043005,GO:0097110,GO:1904115,GO:1904647,GO:1990048,GO:1990049,GO:1990090,GO:1990778" "microtubule motor activity|protein binding|ATP binding|mitochondrion|kinesin complex|microtubule|microtubule associated complex|apoptotic process|microtubule-based movement|neuron-neuron synaptic transmission|neuromuscular synaptic transmission|microtubule binding|synaptic vesicle|anterograde axonal transport|ATP-dependent microtubule motor activity, plus-end-directed|positive regulation of gene expression|vesicle-mediated transport|ATPase activity|kinesin binding|kinase binding|axon|dendrite|cytoplasmic vesicle membrane|cytoskeleton-dependent intracellular transport|cytoplasmic vesicle|lysosome localization|neuron projection|scaffold protein binding|axon cytoplasm|response to rotenone|anterograde neuronal dense core vesicle transport|retrograde neuronal dense core vesicle transport|cellular response to nerve growth factor stimulus|protein localization to cell periphery" KIF1C 4121.30714 4198.070016 4044.544263 0.963429444 -0.053749079 0.822396722 1 43.03558991 40.76794816 10749 kinesin family member 1C "GO:0003723,GO:0003774,GO:0003777,GO:0005515,GO:0005524,GO:0005783,GO:0005794,GO:0005871,GO:0005874,GO:0006890,GO:0007018,GO:0008017,GO:0008574,GO:0016192,GO:0016887,GO:0030424,GO:0030425,GO:0030705,GO:1904115,GO:1990048,GO:1990049" "RNA binding|motor activity|microtubule motor activity|protein binding|ATP binding|endoplasmic reticulum|Golgi apparatus|kinesin complex|microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|vesicle-mediated transport|ATPase activity|axon|dendrite|cytoskeleton-dependent intracellular transport|axon cytoplasm|anterograde neuronal dense core vesicle transport|retrograde neuronal dense core vesicle transport" KIF20A 1915.144446 2183.82874 1646.460153 0.753932817 -0.407492125 0.085307719 1 37.65651894 27.91540906 10112 kinesin family member 20A "GO:0000281,GO:0001578,GO:0003777,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005794,GO:0005819,GO:0005871,GO:0005874,GO:0007018,GO:0008017,GO:0015031,GO:0016887,GO:0019901,GO:0030496,GO:0032154,GO:0032465,GO:0045171,GO:0061952" mitotic cytokinesis|microtubule bundle formation|microtubule motor activity|protein binding|ATP binding|nucleus|nucleoplasm|Golgi apparatus|spindle|kinesin complex|microtubule|microtubule-based movement|microtubule binding|protein transport|ATPase activity|protein kinase binding|midbody|cleavage furrow|regulation of cytokinesis|intercellular bridge|midbody abscission KIF20B 3170.971618 3384.46636 2957.476877 0.873838461 -0.194561489 0.411692959 1 28.0426563 24.0946978 9585 kinesin family member 20B "GO:0001843,GO:0003777,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0005871,GO:0005874,GO:0007018,GO:0007050,GO:0007088,GO:0008017,GO:0008284,GO:0008574,GO:0016887,GO:0030426,GO:0030496,GO:0032467,GO:0035372,GO:0042803,GO:0045171,GO:0048471,GO:0048812,GO:0050699,GO:0051233,GO:0051301,GO:0070938,GO:0090316,GO:0097431,GO:1903438,GO:1990023,GO:2000114,GO:2001224" "neural tube closure|microtubule motor activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|cytosol|kinesin complex|microtubule|microtubule-based movement|cell cycle arrest|regulation of mitotic nuclear division|microtubule binding|positive regulation of cell population proliferation|ATP-dependent microtubule motor activity, plus-end-directed|ATPase activity|growth cone|midbody|positive regulation of cytokinesis|protein localization to microtubule|protein homodimerization activity|intercellular bridge|perinuclear region of cytoplasm|neuron projection morphogenesis|WW domain binding|spindle midzone|cell division|contractile ring|positive regulation of intracellular protein transport|mitotic spindle pole|positive regulation of mitotic cytokinetic process|mitotic spindle midzone|regulation of establishment of cell polarity|positive regulation of neuron migration" KIF21A 912.963681 930.1300111 895.797351 0.963088321 -0.054259986 0.830750522 1 7.787783054 7.374815162 55605 kinesin family member 21A "GO:0003777,GO:0005515,GO:0005524,GO:0005829,GO:0005871,GO:0005874,GO:0005886,GO:0007018,GO:0008017,GO:0016887" microtubule motor activity|protein binding|ATP binding|cytosol|kinesin complex|microtubule|plasma membrane|microtubule-based movement|microtubule binding|ATPase activity KIF21B 215.6688429 274.669265 156.6684208 0.57038934 -0.809981075 0.02190122 0.822216713 1.486069936 0.833454369 23046 kinesin family member 21B "GO:0003777,GO:0005524,GO:0005871,GO:0005874,GO:0007018,GO:0008017,GO:0016887,GO:0030425,GO:0030426,GO:0031410" microtubule motor activity|ATP binding|kinesin complex|microtubule|microtubule-based movement|microtubule binding|ATPase activity|dendrite|growth cone|cytoplasmic vesicle KIF22 2059.893381 2047.534521 2072.252241 1.012071943 0.017311848 0.943841914 1 45.49257043 45.27130775 3835 kinesin family member 22 "GO:0000278,GO:0000776,GO:0000785,GO:0003677,GO:0003777,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0005871,GO:0005874,GO:0006281,GO:0006890,GO:0007018,GO:0007062,GO:0007080,GO:0008017,GO:0016607,GO:0016887,GO:0019886,GO:0051310,GO:0072686" "mitotic cell cycle|kinetochore|chromatin|DNA binding|microtubule motor activity|protein binding|ATP binding|nucleus|cytosol|kinesin complex|microtubule|DNA repair|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|sister chromatid cohesion|mitotic metaphase plate congression|microtubule binding|nuclear speck|ATPase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|metaphase plate congression|mitotic spindle" hsa04914 Progesterone-mediated oocyte maturation KIF23 2750.786606 2787.268792 2714.30442 0.973822269 -0.038269602 0.87287572 1 39.49851636 37.82088294 9493 kinesin family member 23 "GO:0000022,GO:0000281,GO:0003777,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005813,GO:0005819,GO:0005829,GO:0005871,GO:0005874,GO:0005925,GO:0006890,GO:0007018,GO:0008017,GO:0016887,GO:0019886,GO:0030496,GO:0032467,GO:0051256,GO:0072686,GO:0090543,GO:0097149" "mitotic spindle elongation|mitotic cytokinesis|microtubule motor activity|protein binding|ATP binding|nucleus|nucleoplasm|centrosome|spindle|cytosol|kinesin complex|microtubule|focal adhesion|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|microtubule binding|ATPase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|midbody|positive regulation of cytokinesis|mitotic spindle midzone assembly|mitotic spindle|Flemming body|centralspindlin complex" hsa05206 MicroRNAs in cancer KIF24 610.5077545 761.5829621 459.432547 0.603260012 -0.72914814 0.005473187 0.450000583 4.386389268 2.601853787 347240 kinesin family member 24 "GO:0003777,GO:0005515,GO:0005524,GO:0005814,GO:0005829,GO:0005874,GO:0007018,GO:0007019,GO:0008017,GO:0032991,GO:0042802,GO:0060271,GO:0097711" microtubule motor activity|protein binding|ATP binding|centriole|cytosol|microtubule|microtubule-based movement|microtubule depolymerization|microtubule binding|protein-containing complex|identical protein binding|cilium assembly|ciliary basal body-plasma membrane docking KIF26B 2.080827765 4.161655531 0 0 #NAME? 0.234194363 1 0.016339285 0 55083 kinesin family member 26B "GO:0003777,GO:0005524,GO:0005737,GO:0005871,GO:0005874,GO:0007018,GO:0008017,GO:0016887,GO:0022409,GO:0030010,GO:0072092" microtubule motor activity|ATP binding|cytoplasm|kinesin complex|microtubule|microtubule-based movement|microtubule binding|ATPase activity|positive regulation of cell-cell adhesion|establishment of cell polarity|ureteric bud invasion KIF27 115.4815249 142.5367019 88.42634795 0.620375993 -0.688785237 0.121442325 1 0.763977283 0.466022201 55582 kinesin family member 27 "GO:0003351,GO:0003777,GO:0005515,GO:0005524,GO:0005576,GO:0005737,GO:0005871,GO:0005874,GO:0005929,GO:0007018,GO:0008017,GO:0016887,GO:0021591,GO:0060271" epithelial cilium movement involved in extracellular fluid movement|microtubule motor activity|protein binding|ATP binding|extracellular region|cytoplasm|kinesin complex|microtubule|cilium|microtubule-based movement|microtubule binding|ATPase activity|ventricular system development|cilium assembly KIF2A 3044.419136 2888.188938 3200.649333 1.10818558 0.148199499 0.531818202 1 19.01990812 20.72488302 3796 kinesin family member 2A "GO:0000226,GO:0000922,GO:0003774,GO:0003777,GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005814,GO:0005819,GO:0005829,GO:0005871,GO:0005874,GO:0005876,GO:0006890,GO:0007018,GO:0007019,GO:0007052,GO:0007399,GO:0008017,GO:0016020,GO:0016604,GO:0016887,GO:0019886,GO:0030154,GO:0030334,GO:0051301,GO:0090307,GO:0120103" "microtubule cytoskeleton organization|spindle pole|motor activity|microtubule motor activity|protein binding|ATP binding|nucleoplasm|nucleolus|cytoplasm|centrosome|centriole|spindle|cytosol|kinesin complex|microtubule|spindle microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|microtubule depolymerization|mitotic spindle organization|nervous system development|microtubule binding|membrane|nuclear body|ATPase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|cell differentiation|regulation of cell migration|cell division|mitotic spindle assembly|centriolar subdistal appendage" KIF2C 4268.82703 4639.205503 3898.448558 0.840326766 -0.250977657 0.292944453 1 71.20675041 58.83564817 11004 kinesin family member 2C "GO:0000775,GO:0000776,GO:0000777,GO:0003777,GO:0005515,GO:0005524,GO:0005634,GO:0005813,GO:0005819,GO:0005829,GO:0005871,GO:0005874,GO:0005881,GO:0006890,GO:0007018,GO:0007019,GO:0007080,GO:0008017,GO:0015630,GO:0016020,GO:0016887,GO:0019237,GO:0019886,GO:0030951,GO:0035371,GO:0051010,GO:0051301,GO:0051310,GO:0051315,GO:0051983" "chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|microtubule motor activity|protein binding|ATP binding|nucleus|centrosome|spindle|cytosol|kinesin complex|microtubule|cytoplasmic microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|microtubule depolymerization|mitotic metaphase plate congression|microtubule binding|microtubule cytoskeleton|membrane|ATPase activity|centromeric DNA binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|establishment or maintenance of microtubule cytoskeleton polarity|microtubule plus-end|microtubule plus-end binding|cell division|metaphase plate congression|attachment of mitotic spindle microtubules to kinetochore|regulation of chromosome segregation" KIF3A 711.3951457 647.137435 775.6528565 1.198590615 0.261338983 0.307319654 1 4.772876661 5.624996586 11127 kinesin family member 3A "GO:0003777,GO:0005515,GO:0005524,GO:0005813,GO:0005814,GO:0005829,GO:0005871,GO:0005874,GO:0005876,GO:0005929,GO:0006890,GO:0006996,GO:0007018,GO:0008017,GO:0008089,GO:0008574,GO:0010457,GO:0015031,GO:0015630,GO:0016887,GO:0016939,GO:0019886,GO:0019903,GO:0030507,GO:0031267,GO:0034454,GO:0035735,GO:0060271,GO:0070062,GO:0072383,GO:0097542,GO:1902414,GO:1904115" "microtubule motor activity|protein binding|ATP binding|centrosome|centriole|cytosol|kinesin complex|microtubule|spindle microtubule|cilium|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|organelle organization|microtubule-based movement|microtubule binding|anterograde axonal transport|ATP-dependent microtubule motor activity, plus-end-directed|centriole-centriole cohesion|protein transport|microtubule cytoskeleton|ATPase activity|kinesin II complex|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein phosphatase binding|spectrin binding|small GTPase binding|microtubule anchoring at centrosome|intraciliary transport involved in cilium assembly|cilium assembly|extracellular exosome|plus-end-directed vesicle transport along microtubule|ciliary tip|protein localization to cell junction|axon cytoplasm" hsa04340 Hedgehog signaling pathway KIF3B 2590.821493 3117.079992 2064.562993 0.662338791 -0.59435874 0.01210098 0.654074708 27.19961253 17.71389585 9371 kinesin family member 3B "GO:0003777,GO:0005515,GO:0005524,GO:0005813,GO:0005829,GO:0005871,GO:0005873,GO:0005874,GO:0005876,GO:0005929,GO:0006890,GO:0007018,GO:0007052,GO:0007100,GO:0007368,GO:0008017,GO:0008089,GO:0008574,GO:0015630,GO:0016020,GO:0016887,GO:0016939,GO:0019886,GO:0030496,GO:0031267,GO:0032467,GO:0035735,GO:0070062,GO:0072383,GO:0090307,GO:0097542,GO:0120170,GO:1904115" "microtubule motor activity|protein binding|ATP binding|centrosome|cytosol|kinesin complex|plus-end kinesin complex|microtubule|spindle microtubule|cilium|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|mitotic spindle organization|mitotic centrosome separation|determination of left/right symmetry|microtubule binding|anterograde axonal transport|ATP-dependent microtubule motor activity, plus-end-directed|microtubule cytoskeleton|membrane|ATPase activity|kinesin II complex|antigen processing and presentation of exogenous peptide antigen via MHC class II|midbody|small GTPase binding|positive regulation of cytokinesis|intraciliary transport involved in cilium assembly|extracellular exosome|plus-end-directed vesicle transport along microtubule|mitotic spindle assembly|ciliary tip|intraciliary transport particle B binding|axon cytoplasm" KIF3C 1667.367426 1684.430076 1650.304776 0.979740744 -0.029528056 0.903620885 1 16.82795532 16.21114529 3797 kinesin family member 3C "GO:0003774,GO:0003777,GO:0005515,GO:0005524,GO:0005829,GO:0005871,GO:0005874,GO:0005929,GO:0006890,GO:0007018,GO:0008017,GO:0016887,GO:0019886,GO:0035735,GO:0072384,GO:0097542" "motor activity|microtubule motor activity|protein binding|ATP binding|cytosol|kinesin complex|microtubule|cilium|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|microtubule binding|ATPase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|intraciliary transport involved in cilium assembly|organelle transport along microtubule|ciliary tip" KIF4A 2310.480256 2431.447244 2189.513268 0.900497954 -0.151205097 0.522937843 1 29.57198509 26.18390324 24137 kinesin family member 4A "GO:0000281,GO:0003677,GO:0003777,GO:0005515,GO:0005524,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0005876,GO:0006890,GO:0006996,GO:0007018,GO:0007052,GO:0008017,GO:0008089,GO:0016020,GO:0016363,GO:0019886,GO:0030496,GO:0046872,GO:0051256,GO:0051536,GO:1904115" "mitotic cytokinesis|DNA binding|microtubule motor activity|protein binding|ATP binding|nucleoplasm|chromosome|cytoplasm|cytosol|spindle microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|organelle organization|microtubule-based movement|mitotic spindle organization|microtubule binding|anterograde axonal transport|membrane|nuclear matrix|antigen processing and presentation of exogenous peptide antigen via MHC class II|midbody|metal ion binding|mitotic spindle midzone assembly|iron-sulfur cluster binding|axon cytoplasm" KIF4B 19.45586248 18.72744989 20.18427508 1.0777909 0.108077311 0.966287111 1 0.227820739 0.241434288 285643 kinesin family member 4B "GO:0000281,GO:0003677,GO:0003777,GO:0005524,GO:0005654,GO:0005829,GO:0005874,GO:0006890,GO:0007018,GO:0007052,GO:0008017,GO:0016363,GO:0019886,GO:0046872,GO:0051256,GO:0051536" "mitotic cytokinesis|DNA binding|microtubule motor activity|ATP binding|nucleoplasm|cytosol|microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|mitotic spindle organization|microtubule binding|nuclear matrix|antigen processing and presentation of exogenous peptide antigen via MHC class II|metal ion binding|mitotic spindle midzone assembly|iron-sulfur cluster binding" KIF5A 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.038432239 0.01745519 3798 kinesin family member 5A "GO:0003774,GO:0003777,GO:0005515,GO:0005524,GO:0005829,GO:0005871,GO:0005874,GO:0006890,GO:0007018,GO:0007268,GO:0007411,GO:0008017,GO:0008574,GO:0016020,GO:0016192,GO:0016887,GO:0019886,GO:0030705,GO:0032839,GO:0043204,GO:0045202,GO:0048471,GO:0048489,GO:0098971,GO:0099641,GO:1904115,GO:1990049" "motor activity|microtubule motor activity|protein binding|ATP binding|cytosol|kinesin complex|microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|chemical synaptic transmission|axon guidance|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|membrane|vesicle-mediated transport|ATPase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|cytoskeleton-dependent intracellular transport|dendrite cytoplasm|perikaryon|synapse|perinuclear region of cytoplasm|synaptic vesicle transport|anterograde dendritic transport of neurotransmitter receptor complex|anterograde axonal protein transport|axon cytoplasm|retrograde neuronal dense core vesicle transport" "hsa04144,hsa04728,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05132,hsa05223" Endocytosis|Dopaminergic synapse|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection|Non-small cell lung cancer KIF5B 3957.530658 3948.370685 3966.69063 1.004639875 0.006678443 0.978807956 1 34.72598659 34.30332227 3799 kinesin family member 5B "GO:0003777,GO:0005515,GO:0005524,GO:0005829,GO:0005871,GO:0005874,GO:0007018,GO:0007028,GO:0007411,GO:0008017,GO:0008432,GO:0008574,GO:0016020,GO:0016887,GO:0021766,GO:0030705,GO:0031340,GO:0031982,GO:0032230,GO:0032839,GO:0034451,GO:0035253,GO:0035617,GO:0035774,GO:0042391,GO:0042802,GO:0043268,GO:0044295,GO:0045296,GO:0045335,GO:0047496,GO:0048471,GO:0048489,GO:0051642,GO:0071346,GO:0072383,GO:0090316,GO:0098971,GO:0099609,GO:0099641,GO:1903078,GO:1904115,GO:1905152,GO:1990048,GO:1990049" "microtubule motor activity|protein binding|ATP binding|cytosol|kinesin complex|microtubule|microtubule-based movement|cytoplasm organization|axon guidance|microtubule binding|JUN kinase binding|ATP-dependent microtubule motor activity, plus-end-directed|membrane|ATPase activity|hippocampus development|cytoskeleton-dependent intracellular transport|positive regulation of vesicle fusion|vesicle|positive regulation of synaptic transmission, GABAergic|dendrite cytoplasm|centriolar satellite|ciliary rootlet|stress granule disassembly|positive regulation of insulin secretion involved in cellular response to glucose stimulus|regulation of membrane potential|identical protein binding|positive regulation of potassium ion transport|axonal growth cone|cadherin binding|phagocytic vesicle|vesicle transport along microtubule|perinuclear region of cytoplasm|synaptic vesicle transport|centrosome localization|cellular response to interferon-gamma|plus-end-directed vesicle transport along microtubule|positive regulation of intracellular protein transport|anterograde dendritic transport of neurotransmitter receptor complex|microtubule lateral binding|anterograde axonal protein transport|positive regulation of protein localization to plasma membrane|axon cytoplasm|positive regulation of voltage-gated sodium channel activity|anterograde neuronal dense core vesicle transport|retrograde neuronal dense core vesicle transport" "hsa04144,hsa04728,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05132,hsa05223" Endocytosis|Dopaminergic synapse|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection|Non-small cell lung cancer KIF5C 1308.611492 1198.556793 1418.666191 1.183645364 0.243236895 0.312305736 1 8.535464796 9.933903924 3800 kinesin family member 5C "GO:0003777,GO:0005515,GO:0005524,GO:0005871,GO:0005874,GO:0006996,GO:0007018,GO:0007411,GO:0008017,GO:0008045,GO:0008574,GO:0016887,GO:0030705,GO:0032839,GO:0035253,GO:0043025,GO:0044295,GO:0048489,GO:0051028,GO:0098971,GO:0099641,GO:0150034,GO:1904115" "microtubule motor activity|protein binding|ATP binding|kinesin complex|microtubule|organelle organization|microtubule-based movement|axon guidance|microtubule binding|motor neuron axon guidance|ATP-dependent microtubule motor activity, plus-end-directed|ATPase activity|cytoskeleton-dependent intracellular transport|dendrite cytoplasm|ciliary rootlet|neuronal cell body|axonal growth cone|synaptic vesicle transport|mRNA transport|anterograde dendritic transport of neurotransmitter receptor complex|anterograde axonal protein transport|distal axon|axon cytoplasm" "hsa04144,hsa04728,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05132,hsa05223" Endocytosis|Dopaminergic synapse|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection|Non-small cell lung cancer KIF7 575.2135548 591.9954992 558.4316104 0.943303811 -0.084205599 0.755957426 1 6.67943166 6.1952991 374654 kinesin family member 7 "GO:0003777,GO:0005515,GO:0005524,GO:0005737,GO:0005871,GO:0005874,GO:0005929,GO:0007018,GO:0008017,GO:0016887,GO:0036064,GO:0045879,GO:0045880,GO:0097542" microtubule motor activity|protein binding|ATP binding|cytoplasm|kinesin complex|microtubule|cilium|microtubule-based movement|microtubule binding|ATPase activity|ciliary basal body|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway|ciliary tip "hsa04340,hsa05200,hsa05217" Hedgehog signaling pathway|Pathways in cancer|Basal cell carcinoma KIF9 56.96548247 57.22276355 56.7082014 0.991007737 -0.013031774 1 1 0.74831505 0.729176567 64147 kinesin family member 9 "GO:0002102,GO:0003777,GO:0005515,GO:0005524,GO:0005737,GO:0005871,GO:0005874,GO:0007018,GO:0008017,GO:0016887,GO:0022617,GO:0031982,GO:0042802,GO:0071801,GO:1903008" podosome|microtubule motor activity|protein binding|ATP binding|cytoplasm|kinesin complex|microtubule|microtubule-based movement|microtubule binding|ATPase activity|extracellular matrix disassembly|vesicle|identical protein binding|regulation of podosome assembly|organelle disassembly KIFAP3 829.0222795 732.4513734 925.5931856 1.263692334 0.337645259 0.177940528 1 8.126732559 10.09784029 22920 kinesin associated protein 3 "GO:0000794,GO:0005515,GO:0005783,GO:0005794,GO:0005813,GO:0005829,GO:0005876,GO:0005929,GO:0005930,GO:0006890,GO:0007017,GO:0007018,GO:0007165,GO:0008285,GO:0015630,GO:0016939,GO:0019886,GO:0019894,GO:0019903,GO:0032391,GO:0035735,GO:0035869,GO:0036064,GO:0043066,GO:0044782,GO:0046587,GO:0065003,GO:0072383,GO:0097542,GO:0120170,GO:1990075" "condensed nuclear chromosome|protein binding|endoplasmic reticulum|Golgi apparatus|centrosome|cytosol|spindle microtubule|cilium|axoneme|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based process|microtubule-based movement|signal transduction|negative regulation of cell population proliferation|microtubule cytoskeleton|kinesin II complex|antigen processing and presentation of exogenous peptide antigen via MHC class II|kinesin binding|protein phosphatase binding|photoreceptor connecting cilium|intraciliary transport involved in cilium assembly|ciliary transition zone|ciliary basal body|negative regulation of apoptotic process|cilium organization|positive regulation of calcium-dependent cell-cell adhesion|protein-containing complex assembly|plus-end-directed vesicle transport along microtubule|ciliary tip|intraciliary transport particle B binding|periciliary membrane compartment" KIFBP 2310.204696 2121.403907 2499.005486 1.17799608 0.236334738 0.317553565 1 29.12668575 33.73697148 26128 kinesin family binding protein "GO:0005515,GO:0005739,GO:0005856,GO:0006839,GO:0007399,GO:0019894,GO:0030154" protein binding|mitochondrion|cytoskeleton|mitochondrial transport|nervous system development|kinesin binding|cell differentiation KIFC1 1987.331137 2035.049554 1939.612719 0.953103434 -0.069295306 0.771262106 1 36.26272269 33.98377517 3833 kinesin family member C1 "GO:0000070,GO:0003777,GO:0005524,GO:0005634,GO:0005769,GO:0005815,GO:0005871,GO:0005874,GO:0007018,GO:0007080,GO:0007283,GO:0008017,GO:0016020,GO:0016887,GO:0051301,GO:0072686,GO:0090307" mitotic sister chromatid segregation|microtubule motor activity|ATP binding|nucleus|early endosome|microtubule organizing center|kinesin complex|microtubule|microtubule-based movement|mitotic metaphase plate congression|spermatogenesis|microtubule binding|membrane|ATPase activity|cell division|mitotic spindle|mitotic spindle assembly KIFC2 969.8259823 845.8564866 1093.795478 1.293121818 0.37085819 0.132531306 1 11.557042 14.69458447 90990 kinesin family member C2 "GO:0003777,GO:0005524,GO:0005634,GO:0005737,GO:0005815,GO:0005871,GO:0005874,GO:0007018,GO:0008017,GO:0016887,GO:0072686,GO:0090307" microtubule motor activity|ATP binding|nucleus|cytoplasm|microtubule organizing center|kinesin complex|microtubule|microtubule-based movement|microtubule binding|ATPase activity|mitotic spindle|mitotic spindle assembly KIFC3 2087.438582 2266.021436 1908.855729 0.842382026 -0.247453441 0.295514685 1 22.63822525 18.75092286 3801 kinesin family member C3 "GO:0003777,GO:0005515,GO:0005524,GO:0005794,GO:0005813,GO:0005871,GO:0005874,GO:0005915,GO:0007018,GO:0007030,GO:0007601,GO:0008017,GO:0008569,GO:0030659,GO:0045218,GO:0070062,GO:0090136" "microtubule motor activity|protein binding|ATP binding|Golgi apparatus|centrosome|kinesin complex|microtubule|zonula adherens|microtubule-based movement|Golgi organization|visual perception|microtubule binding|ATP-dependent microtubule motor activity, minus-end-directed|cytoplasmic vesicle membrane|zonula adherens maintenance|extracellular exosome|epithelial cell-cell adhesion" KIN 192.557055 185.1936711 199.9204388 1.079520902 0.110391177 0.776419835 1 1.133032885 1.202665213 22944 Kin17 DNA and RNA binding protein "GO:0003677,GO:0003690,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006260,GO:0006281,GO:0006310,GO:0006397,GO:0006974,GO:0016032,GO:0016363,GO:0032991,GO:0043231,GO:0046872" DNA binding|double-stranded DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|DNA replication|DNA repair|DNA recombination|mRNA processing|cellular response to DNA damage stimulus|viral process|nuclear matrix|protein-containing complex|intracellular membrane-bounded organelle|metal ion binding KIRREL1 3320.774897 3923.400751 2718.149044 0.692804334 -0.52948014 0.025755773 0.86539048 27.81411892 18.94728909 55243 kirre like nephrin family adhesion molecule 1 "GO:0005515,GO:0005886,GO:0005887,GO:0005911,GO:0017022,GO:0031253,GO:0045121,GO:0048471,GO:0050839,GO:0098609" protein binding|plasma membrane|integral component of plasma membrane|cell-cell junction|myosin binding|cell projection membrane|membrane raft|perinuclear region of cytoplasm|cell adhesion molecule binding|cell-cell adhesion KIRREL3 12.29185219 7.282897178 17.30080721 2.375539127 1.248254969 0.245646158 1 0.081757433 0.190968006 84623 kirre like nephrin family adhesion molecule 3 "GO:0001764,GO:0002121,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0005911,GO:0007156,GO:0007416,GO:0008021,GO:0016021,GO:0021740,GO:0021766,GO:0030097,GO:0030424,GO:0030425,GO:0043198,GO:0048812,GO:0050839,GO:0072102,GO:0098609" neuron migration|inter-male aggressive behavior|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|cell-cell junction|homophilic cell adhesion via plasma membrane adhesion molecules|synapse assembly|synaptic vesicle|integral component of membrane|principal sensory nucleus of trigeminal nerve development|hippocampus development|hemopoiesis|axon|dendrite|dendritic shaft|neuron projection morphogenesis|cell adhesion molecule binding|glomerulus morphogenesis|cell-cell adhesion KISS1 735.7473355 441.1354862 1030.359185 2.3356978 1.223853626 2.08E-06 0.001275045 32.97281531 75.72579828 3814 KiSS-1 metastasis suppressor "GO:0005515,GO:0005576,GO:0007010,GO:0007186,GO:0007204,GO:0031773,GO:0043005" protein binding|extracellular region|cytoskeleton organization|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|kisspeptin receptor binding|neuron projection "hsa04080,hsa04929" Neuroactive ligand-receptor interaction|GnRH secretion KITLG 1412.203099 1230.809623 1593.596575 1.294754725 0.372678823 0.119600069 1 12.07242188 15.36926458 4254 KIT ligand "GO:0000165,GO:0001541,GO:0001755,GO:0002687,GO:0002763,GO:0005125,GO:0005173,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005856,GO:0005886,GO:0007155,GO:0008083,GO:0008284,GO:0008584,GO:0016021,GO:0030027,GO:0030175,GO:0033026,GO:0035162,GO:0035234,GO:0043406,GO:0045636,GO:0046579,GO:0050731,GO:0051897,GO:0070668,GO:0097192,GO:1901534,GO:1902035" MAPK cascade|ovarian follicle development|neural crest cell migration|positive regulation of leukocyte migration|positive regulation of myeloid leukocyte differentiation|cytokine activity|stem cell factor receptor binding|protein binding|extracellular region|extracellular space|cytoplasm|cytoskeleton|plasma membrane|cell adhesion|growth factor activity|positive regulation of cell population proliferation|male gonad development|integral component of membrane|lamellipodium|filopodium|negative regulation of mast cell apoptotic process|embryonic hemopoiesis|ectopic germ cell programmed cell death|positive regulation of MAP kinase activity|positive regulation of melanocyte differentiation|positive regulation of Ras protein signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling|positive regulation of mast cell proliferation|extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of hematopoietic progenitor cell differentiation|positive regulation of hematopoietic stem cell proliferation "hsa04010,hsa04014,hsa04015,hsa04072,hsa04151,hsa04640,hsa04916,hsa05200" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Hematopoietic cell lineage|Melanogenesis|Pathways in cancer KIZ 305.9923507 337.094098 274.8906034 0.815471422 -0.294293776 0.348419698 1 7.597167422 6.091603419 55857 kizuna centrosomal protein "GO:0005515,GO:0005737,GO:0005813,GO:0007051,GO:0019901,GO:0042995" protein binding|cytoplasm|centrosome|spindle organization|protein kinase binding|cell projection KLC1 3528.176263 3148.292409 3908.060117 1.241326919 0.311883118 0.189020275 1 53.81761036 65.68735311 3831 kinesin light chain 1 "GO:0003774,GO:0005515,GO:0005829,GO:0005871,GO:0005874,GO:0006890,GO:0007018,GO:0016020,GO:0016032,GO:0019886,GO:0030426,GO:0031410,GO:0035617" "motor activity|protein binding|cytosol|kinesin complex|microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|membrane|viral process|antigen processing and presentation of exogenous peptide antigen via MHC class II|growth cone|cytoplasmic vesicle|stress granule disassembly" "hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05132" Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection KLC2 1507.212885 1391.033361 1623.39241 1.167040601 0.222854753 0.350688675 1 20.25563271 23.24357668 64837 kinesin light chain 2 "GO:0005515,GO:0005654,GO:0005739,GO:0005829,GO:0005871,GO:0005874,GO:0005886,GO:0006890,GO:0007018,GO:0016020,GO:0016938,GO:0019886,GO:0019894,GO:0032991,GO:0045296" "protein binding|nucleoplasm|mitochondrion|cytosol|kinesin complex|microtubule|plasma membrane|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|membrane|kinesin I complex|antigen processing and presentation of exogenous peptide antigen via MHC class II|kinesin binding|protein-containing complex|cadherin binding" "hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05132" Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection KLC3 6.004709516 6.242483296 5.766935736 0.923820772 -0.11431511 1 1 0.171021489 0.155349402 147700 kinesin light chain 3 "GO:0005515,GO:0005737,GO:0005871,GO:0005874,GO:0008017,GO:0008088,GO:0019894,GO:0031514,GO:0035253,GO:0043005" protein binding|cytoplasm|kinesin complex|microtubule|microtubule binding|axo-dendritic transport|kinesin binding|motile cilium|ciliary rootlet|neuron projection "hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05132" Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection KLC4 205.8842906 207.0423626 204.7262186 0.988813188 -0.01623011 0.9791603 1 3.903027328 3.79478365 89953 kinesin light chain 4 "GO:0005515,GO:0005737,GO:0005871,GO:0005874" protein binding|cytoplasm|kinesin complex|microtubule "hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05132" Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection KLF10 2332.755419 2410.638966 2254.871873 0.935383483 -0.096370141 0.684543751 1 40.34222987 37.10400375 7071 Kruppel like factor 10 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001046,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0007267,GO:0007623,GO:0008285,GO:0009267,GO:0030282,GO:0035019,GO:0042752,GO:0045672,GO:0045892,GO:0045944,GO:0046872,GO:1901653,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|core promoter sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|cell-cell signaling|circadian rhythm|negative regulation of cell population proliferation|cellular response to starvation|bone mineralization|somatic stem cell population maintenance|regulation of circadian rhythm|positive regulation of osteoclast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|cellular response to peptide|sequence-specific double-stranded DNA binding" zf-C2H2 KLF11 248.5909496 268.4267817 228.7551175 0.852206758 -0.230724602 0.496387079 1 3.312241386 2.77548019 8462 Kruppel like factor 11 "GO:0000083,GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005925,GO:0006357,GO:0006915,GO:0008285,GO:0016604,GO:0043065,GO:0046872,GO:1901653,GO:1990837" "regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|focal adhesion|regulation of transcription by RNA polymerase II|apoptotic process|negative regulation of cell population proliferation|nuclear body|positive regulation of apoptotic process|metal ion binding|cellular response to peptide|sequence-specific double-stranded DNA binding" KLF12 873.2002405 819.8461395 926.5543416 1.130156376 0.176522407 0.480198107 1 3.710454686 4.123223249 11278 Kruppel like factor 12 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0003700,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0045944,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 KLF13 1114.651718 1115.323682 1113.979753 0.998795032 -0.001739449 0.998535226 1 8.335355698 8.185999043 51621 Kruppel like factor 13 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0006366,GO:0008285,GO:0045647,GO:0045944,GO:0046872,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|negative regulation of cell population proliferation|negative regulation of erythrocyte differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" KLF14 8.447228369 7.282897178 9.61155956 1.31974396 0.400258063 0.833324456 1 0.110702033 0.143653581 136259 Kruppel like factor 14 "GO:0000785,GO:0000978,GO:0000981,GO:0003682,GO:0005634,GO:0006357,GO:0043565,GO:0045944,GO:0046872,GO:1902070,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|chromatin binding|nucleus|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of sphingolipid mediated signaling pathway|sequence-specific double-stranded DNA binding" KLF15 4.562975582 6.242483296 2.883467868 0.461910386 -1.11431511 0.584550016 1 0.114248923 0.051889683 28999 Kruppel like factor 15 "GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001678,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0010001,GO:0014898,GO:0016607,GO:0030111,GO:0032868,GO:0043231,GO:0045944,GO:0046326,GO:0046872,GO:0072112,GO:1901653,GO:1990837,GO:2000757" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|cellular glucose homeostasis|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|glial cell differentiation|cardiac muscle hypertrophy in response to stress|nuclear speck|regulation of Wnt signaling pathway|response to insulin|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|positive regulation of glucose import|metal ion binding|glomerular visceral epithelial cell differentiation|cellular response to peptide|sequence-specific double-stranded DNA binding|negative regulation of peptidyl-lysine acetylation" zf-C2H2 KLF16 698.191213 716.8451651 679.5372609 0.947955422 -0.077108878 0.768019953 1 13.18742122 12.29189868 83855 Kruppel like factor 16 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0007212,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|dopamine receptor signaling pathway|metal ion binding|sequence-specific double-stranded DNA binding" KLF17 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.041633324 0.037818125 128209 Kruppel like factor 17 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" KLF2 380.4718764 362.0640312 398.8797217 1.101682817 0.13970892 0.639326605 1 6.852018403 7.422432812 10365 Kruppel like factor 2 "GO:0000122,GO:0000785,GO:0000902,GO:0000978,GO:0000981,GO:0001701,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0032715,GO:0035264,GO:0036003,GO:0040029,GO:0042311,GO:0043249,GO:0045429,GO:0045893,GO:0045944,GO:0046872,GO:0048386,GO:0051247,GO:0060509,GO:0070301,GO:0071347,GO:0071356,GO:0071409,GO:0071498,GO:0071499,GO:0097533,GO:1901653,GO:1903671,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|cell morphogenesis|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|in utero embryonic development|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|negative regulation of interleukin-6 production|multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter in response to stress|regulation of gene expression, epigenetic|vasodilation|erythrocyte maturation|positive regulation of nitric oxide biosynthetic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of retinoic acid receptor signaling pathway|positive regulation of protein metabolic process|type I pneumocyte differentiation|cellular response to hydrogen peroxide|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to cycloheximide|cellular response to fluid shear stress|cellular response to laminar fluid shear stress|cellular stress response to acid chemical|cellular response to peptide|negative regulation of sprouting angiogenesis|sequence-specific double-stranded DNA binding" "hsa04068,hsa04371,hsa05418" FoxO signaling pathway|Apelin signaling pathway|Fluid shear stress and atherosclerosis KLF3 1187.371249 1333.810598 1040.9319 0.780419576 -0.357678129 0.139861699 1 11.98770969 9.198892635 51274 Kruppel like factor 3 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005654,GO:0006357,GO:0007275,GO:0046872,GO:1901653,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|multicellular organism development|metal ion binding|cellular response to peptide|sequence-specific double-stranded DNA binding" hsa05202 Transcriptional misregulation in cancer zf-C2H2 KLF4 158.2674419 206.0019488 110.5329349 0.536562569 -0.898181679 0.023988227 0.848442542 3.618810201 1.909226077 9314 Kruppel like factor 4 "GO:0000122,GO:0000785,GO:0000791,GO:0000976,GO:0000978,GO:0000981,GO:0000987,GO:0001010,GO:0001085,GO:0001221,GO:0001228,GO:0003700,GO:0005515,GO:0005654,GO:0005667,GO:0005737,GO:0006351,GO:0006357,GO:0007500,GO:0008013,GO:0008270,GO:0008285,GO:0009913,GO:0010628,GO:0010629,GO:0014067,GO:0014740,GO:0016525,GO:0019827,GO:0031077,GO:0032088,GO:0032270,GO:0032717,GO:0034115,GO:0035014,GO:0035019,GO:0035166,GO:0042826,GO:0043154,GO:0043551,GO:0045429,GO:0045444,GO:0045595,GO:0045892,GO:0045893,GO:0045944,GO:0046985,GO:0048662,GO:0048679,GO:0048730,GO:0050728,GO:0051247,GO:0051898,GO:0051973,GO:0060070,GO:0060761,GO:0070301,GO:0070373,GO:0071300,GO:0071363,GO:0071409,GO:0071499,GO:0090051,GO:0120222,GO:1901653,GO:1902895,GO:1903672,GO:1904798,GO:1904998,GO:1990830,GO:1990837,GO:1990841,GO:2000134,GO:2000342" "negative regulation of transcription by RNA polymerase II|chromatin|euchromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity|RNA polymerase II transcription factor binding|transcription coregulator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|transcription regulator complex|cytoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|mesodermal cell fate determination|beta-catenin binding|zinc ion binding|negative regulation of cell population proliferation|epidermal cell differentiation|positive regulation of gene expression|negative regulation of gene expression|negative regulation of phosphatidylinositol 3-kinase signaling|negative regulation of muscle hyperplasia|negative regulation of angiogenesis|stem cell population maintenance|post-embryonic camera-type eye development|negative regulation of NF-kappaB transcription factor activity|positive regulation of cellular protein metabolic process|negative regulation of interleukin-8 production|negative regulation of heterotypic cell-cell adhesion|phosphatidylinositol 3-kinase regulator activity|somatic stem cell population maintenance|post-embryonic hemopoiesis|histone deacetylase binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of phosphatidylinositol 3-kinase activity|positive regulation of nitric oxide biosynthetic process|fat cell differentiation|regulation of cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of hemoglobin biosynthetic process|negative regulation of smooth muscle cell proliferation|regulation of axon regeneration|epidermis morphogenesis|negative regulation of inflammatory response|positive regulation of protein metabolic process|negative regulation of protein kinase B signaling|positive regulation of telomerase activity|canonical Wnt signaling pathway|negative regulation of response to cytokine stimulus|cellular response to hydrogen peroxide|negative regulation of ERK1 and ERK2 cascade|cellular response to retinoic acid|cellular response to growth factor stimulus|cellular response to cycloheximide|cellular response to laminar fluid shear stress|negative regulation of cell migration involved in sprouting angiogenesis|regulation of blastocyst development|cellular response to peptide|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of sprouting angiogenesis|positive regulation of core promoter binding|negative regulation of leukocyte adhesion to arterial endothelial cell|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of chemokine (C-X-C motif) ligand 2 production" hsa04550 Signaling pathways regulating pluripotency of stem cells zf-C2H2 KLF5 1051.399092 1057.060505 1045.73768 0.989288385 -0.015536955 0.953595349 1 15.97207711 15.5365822 688 Kruppel like factor 5 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001525,GO:0005515,GO:0005654,GO:0005667,GO:0005794,GO:0006357,GO:0008284,GO:0014816,GO:0014901,GO:0014908,GO:0030033,GO:0032534,GO:0043231,GO:0043426,GO:0045600,GO:0045944,GO:0046872,GO:0060576,GO:0061586,GO:0071407,GO:0099156,GO:1901653,GO:1902895,GO:1990830,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|protein binding|nucleoplasm|transcription regulator complex|Golgi apparatus|regulation of transcription by RNA polymerase II|positive regulation of cell population proliferation|skeletal muscle satellite cell differentiation|satellite cell activation involved in skeletal muscle regeneration|myotube differentiation involved in skeletal muscle regeneration|microvillus assembly|regulation of microvillus assembly|intracellular membrane-bounded organelle|MRF binding|positive regulation of fat cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|intestinal epithelial cell development|positive regulation of transcription by transcription factor localization|cellular response to organic cyclic compound|cell-cell signaling via exosome|cellular response to peptide|positive regulation of pri-miRNA transcription by RNA polymerase II|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding" zf-C2H2 KLF6 3613.093297 3409.436293 3816.750301 1.119466672 0.162811578 0.493327175 1 39.64168817 43.63495055 1316 Kruppel like factor 6 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0030183,GO:0043231,GO:0045893,GO:0045944,GO:0046872,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|fibrillar center|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|B cell differentiation|intracellular membrane-bounded organelle|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 KLF7 1554.709619 1590.792827 1518.62641 0.954634937 -0.066978958 0.780749011 1 4.918753731 4.617039417 8609 Kruppel like factor 7 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007409,GO:0007411,GO:0008270,GO:0042593,GO:0045604,GO:0045944,GO:0048813,GO:0061179,GO:1904178" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|axonogenesis|axon guidance|zinc ion binding|glucose homeostasis|regulation of epidermal cell differentiation|positive regulation of transcription by RNA polymerase II|dendrite morphogenesis|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of adipose tissue development" zf-C2H2 KLF8 10.40916924 8.323311061 12.49502743 1.501208754 0.586124608 0.656643747 1 0.042892991 0.063313832 11279 Kruppel like factor 8 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005654,GO:0005829,GO:0006357,GO:0016235,GO:0046872" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|aggresome|metal ion binding" KLF9 542.8311624 650.2586767 435.4036481 0.669585295 -0.578660249 0.030996256 0.895820653 6.672391934 4.39297402 687 Kruppel like factor 9 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006357,GO:0007623,GO:0010839,GO:0046872,GO:0071387,GO:0097067" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|circadian rhythm|negative regulation of keratinocyte proliferation|metal ion binding|cellular response to cortisol stimulus|cellular response to thyroid hormone stimulus" zf-C2H2 KLHDC1 36.07291648 26.01034707 46.13548589 1.773735882 0.826791201 0.22596565 1 0.188194742 0.328221946 122773 kelch domain containing 1 GO:0005829 cytosol KLHDC10 1207.194447 1236.011693 1178.377202 0.953370594 -0.068890967 0.778639483 1 10.3068238 9.661794205 23008 kelch domain containing 10 "GO:0005515,GO:0005654,GO:0005737,GO:0032874" protein binding|nucleoplasm|cytoplasm|positive regulation of stress-activated MAPK cascade KLHDC2 1030.49205 962.3828414 1098.601258 1.141542856 0.190985023 0.437088673 1 15.29044462 17.16261709 23588 kelch domain containing 2 "GO:0005515,GO:0005654,GO:0016604,GO:0031965" protein binding|nucleoplasm|nuclear body|nuclear membrane KLHDC3 911.1803777 883.3113864 939.049369 1.063101171 0.088278899 0.725137142 1 23.09686685 24.14342312 116138 kelch domain containing 3 "GO:0000785,GO:0003682,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0007131,GO:0036498" chromatin|chromatin binding|protein binding|nucleoplasm|cytoplasm|cytosol|reciprocal meiotic recombination|IRE1-mediated unfolded protein response KLHDC4 492.7529018 496.277422 489.2283816 0.985796169 -0.02063872 0.948006351 1 4.366207368 4.232165699 54758 kelch domain containing 4 GO:0005515 protein binding KLHDC7B 5.16244045 9.363724944 0.961155956 0.102646752 -3.284240111 0.082212168 1 0.097507276 0.009841321 113730 kelch domain containing 7B GO:0005515 protein binding KLHDC8B 160.2149059 143.5771158 176.8526959 1.231761029 0.300722389 0.45263508 1 3.100949732 3.755712713 200942 kelch domain containing 8B "GO:0005737,GO:0005829,GO:0030496,GO:0045171,GO:0098813,GO:0110070,GO:0140014,GO:1902410" cytoplasm|cytosol|midbody|intercellular bridge|nuclear chromosome segregation|cellularization cleavage furrow|mitotic nuclear division|mitotic cytokinetic process KLHDC9 42.47391563 42.65696919 42.29086206 0.991417414 -0.012435496 1 1 1.666562259 1.62461053 126823 kelch domain containing 9 "GO:0005515,GO:0005575,GO:0008150,GO:0030332" protein binding|cellular_component|biological_process|cyclin binding KLHL11 234.3868464 236.1739514 232.5997414 0.984866197 -0.02200036 0.962511725 1 1.70280596 1.648973103 55175 kelch like family member 11 "GO:0005515,GO:0005829,GO:0043687" protein binding|cytosol|post-translational protein modification KLHL12 1047.41546 1103.879129 990.9517906 0.897699544 -0.155695433 0.526314509 1 16.90444772 14.92118 59349 kelch like family member 12 "GO:0000139,GO:0005515,GO:0005829,GO:0006513,GO:0006888,GO:0014029,GO:0014032,GO:0016055,GO:0030127,GO:0030134,GO:0031463,GO:0034451,GO:0042802,GO:0043231,GO:0048208,GO:0090090" Golgi membrane|protein binding|cytosol|protein monoubiquitination|endoplasmic reticulum to Golgi vesicle-mediated transport|neural crest formation|neural crest cell development|Wnt signaling pathway|COPII vesicle coat|COPII-coated ER to Golgi transport vesicle|Cul3-RING ubiquitin ligase complex|centriolar satellite|identical protein binding|intracellular membrane-bounded organelle|COPII vesicle coating|negative regulation of canonical Wnt signaling pathway KLHL13 333.0336652 315.2454064 350.8219239 1.112853405 0.15426356 0.618561299 1 3.283385626 3.592783355 90293 kelch like family member 13 "GO:0004842,GO:0005515,GO:0005829,GO:0007049,GO:0016567,GO:0030496,GO:0031463,GO:0032465,GO:0043687,GO:0047485,GO:0051301,GO:0097602" ubiquitin-protein transferase activity|protein binding|cytosol|cell cycle|protein ubiquitination|midbody|Cul3-RING ubiquitin ligase complex|regulation of cytokinesis|post-translational protein modification|protein N-terminus binding|cell division|cullin family protein binding hsa04120 Ubiquitin mediated proteolysis KLHL15 276.6626172 273.6288511 279.6963832 1.022174314 0.031641244 0.93411094 1 2.32829542 2.340098973 80311 kelch like family member 15 "GO:0005515,GO:0005634,GO:0006511,GO:0016567,GO:0031463,GO:0071630,GO:2000042" protein binding|nucleus|ubiquitin-dependent protein catabolic process|protein ubiquitination|Cul3-RING ubiquitin ligase complex|nuclear protein quality control by the ubiquitin-proteasome system|negative regulation of double-strand break repair via homologous recombination KLHL17 389.1323409 337.094098 441.1705838 1.308746093 0.388185231 0.183147529 1 5.489805449 7.064534182 339451 kelch like family member 17 "GO:0005515,GO:0005615,GO:0007420,GO:0014069,GO:0015629,GO:0016567,GO:0030036,GO:0031208,GO:0032839,GO:0043025,GO:0051015,GO:0060090" protein binding|extracellular space|brain development|postsynaptic density|actin cytoskeleton|protein ubiquitination|actin cytoskeleton organization|POZ domain binding|dendrite cytoplasm|neuronal cell body|actin filament binding|molecular adaptor activity KLHL18 589.9428955 612.8037769 567.082014 0.925389228 -0.111867789 0.67575946 1 7.024100362 6.391257666 23276 kelch like family member 18 "GO:0005515,GO:0007049,GO:0016567,GO:0051301,GO:1901992" protein binding|cell cycle|protein ubiquitination|cell division|positive regulation of mitotic cell cycle phase transition KLHL2 370.9741734 377.6702394 364.2781073 0.964540145 -0.05208681 0.868831735 1 5.192057328 4.924146503 11275 kelch like family member 2 "GO:0001726,GO:0003779,GO:0005515,GO:0005737,GO:0005829,GO:0015629,GO:0016567,GO:0030027,GO:0031463,GO:0042802,GO:0043687" ruffle|actin binding|protein binding|cytoplasm|cytosol|actin cytoskeleton|protein ubiquitination|lamellipodium|Cul3-RING ubiquitin ligase complex|identical protein binding|post-translational protein modification KLHL20 435.1036661 446.3375557 423.8697766 0.949661912 -0.074514102 0.799160456 1 5.904862422 5.513786964 27252 kelch like family member 20 "GO:0003779,GO:0004842,GO:0005515,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0006895,GO:0007010,GO:0015031,GO:0015629,GO:0016567,GO:0016605,GO:0019964,GO:0030424,GO:0030425,GO:0031463,GO:0035455,GO:0043066,GO:0043161,GO:0043687,GO:0048471,GO:1990390" actin binding|ubiquitin-protein transferase activity|protein binding|cytoplasm|Golgi apparatus|trans-Golgi network|cytosol|Golgi to endosome transport|cytoskeleton organization|protein transport|actin cytoskeleton|protein ubiquitination|PML body|interferon-gamma binding|axon|dendrite|Cul3-RING ubiquitin ligase complex|response to interferon-alpha|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|perinuclear region of cytoplasm|protein K33-linked ubiquitination KLHL21 1329.572026 1458.660263 1200.483789 0.823004382 -0.281027982 0.242255853 1 15.76149369 12.75471324 9903 kelch like family member 21 "GO:0004842,GO:0005515,GO:0005827,GO:0005829,GO:0007049,GO:0016567,GO:0031463,GO:0032465,GO:0035853,GO:0043687,GO:0051301,GO:0097602" ubiquitin-protein transferase activity|protein binding|polar microtubule|cytosol|cell cycle|protein ubiquitination|Cul3-RING ubiquitin ligase complex|regulation of cytokinesis|chromosome passenger complex localization to spindle midzone|post-translational protein modification|cell division|cullin family protein binding KLHL22 358.107394 405.7614142 310.4533738 0.765113101 -0.386255069 0.195524834 1 4.768716344 3.587552846 84861 kelch like family member 22 "GO:0000070,GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005813,GO:0005827,GO:0005829,GO:0006513,GO:0007094,GO:0010507,GO:0015630,GO:0030307,GO:0031463,GO:0043161,GO:0043231,GO:0043687,GO:0045171,GO:0051301,GO:0071233,GO:0071889,GO:0072686,GO:1904263" mitotic sister chromatid segregation|protein binding|nucleus|cytoplasm|lysosome|centrosome|polar microtubule|cytosol|protein monoubiquitination|mitotic spindle assembly checkpoint|negative regulation of autophagy|microtubule cytoskeleton|positive regulation of cell growth|Cul3-RING ubiquitin ligase complex|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|post-translational protein modification|intercellular bridge|cell division|cellular response to leucine|14-3-3 protein binding|mitotic spindle|positive regulation of TORC1 signaling KLHL23 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.040817185 0.049435699 151230 kelch like family member 23 GO:0005515 protein binding KLHL24 510.9400231 582.6317743 439.2482719 0.753903737 -0.407547772 0.133787629 1 4.316211405 3.199556492 54800 kelch like family member 24 "GO:0005515,GO:0005737,GO:0005912,GO:0016567,GO:0030057,GO:0030424,GO:0031463,GO:0043204,GO:0045109,GO:0051865,GO:2000312" protein binding|cytoplasm|adherens junction|protein ubiquitination|desmosome|axon|Cul3-RING ubiquitin ligase complex|perikaryon|intermediate filament organization|protein autoubiquitination|regulation of kainate selective glutamate receptor activity KLHL25 150.7172028 159.183324 142.2510815 0.89363055 -0.162249587 0.70008268 1 2.327485325 2.045107482 64410 kelch like family member 25 "GO:0005737,GO:0005829,GO:0006446,GO:0006511,GO:0016567,GO:0031463,GO:0043687" cytoplasm|cytosol|regulation of translational initiation|ubiquitin-dependent protein catabolic process|protein ubiquitination|Cul3-RING ubiquitin ligase complex|post-translational protein modification KLHL26 135.8243159 146.6983575 124.9502743 0.851749648 -0.231498649 0.591145664 1 1.651343961 1.382995235 55295 kelch like family member 26 GO:0005515 protein binding KLHL28 308.0140422 289.2350594 326.793025 1.129852742 0.176134754 0.57797152 1 2.005188819 2.227656872 54813 kelch like family member 28 KLHL29 699.0781415 702.2793708 695.8769121 0.990883317 -0.013212915 0.965038324 1 5.405157093 5.266256589 114818 kelch like family member 29 GO:0005515 protein binding KLHL31 4.523346619 5.202069413 3.844623824 0.739056617 -0.436243205 0.933440272 1 0.038877592 0.028251938 401265 kelch like family member 31 "GO:0001933,GO:0005634,GO:0005737,GO:0046329" negative regulation of protein phosphorylation|nucleus|cytoplasm|negative regulation of JNK cascade KLHL32 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.005253073 0.014315073 114792 kelch like family member 32 GO:0005515 protein binding KLHL35 37.91094004 36.41448589 39.4073942 1.082190047 0.113953878 0.904244363 1 0.925416279 0.984717937 283212 kelch like family member 35 GO:0005515 protein binding KLHL36 1368.3856 1342.133909 1394.637292 1.039119333 0.055361344 0.82011383 1 9.052985334 9.249716468 79786 kelch like family member 36 "GO:0005515,GO:0005575,GO:0008150,GO:0016567,GO:0097602" protein binding|cellular_component|biological_process|protein ubiquitination|cullin family protein binding KLHL4 4.042768641 5.202069413 2.883467868 0.554292463 -0.851280704 0.745112452 1 0.048156962 0.026246369 56062 kelch like family member 4 "GO:0003674,GO:0003779,GO:0005737,GO:0008150,GO:0015630,GO:0034451" molecular_function|actin binding|cytoplasm|biological_process|microtubule cytoskeleton|centriolar satellite KLHL42 1244.500892 1281.789903 1207.211881 0.94181728 -0.086480902 0.722539762 1 9.831384207 9.10442456 57542 kelch like family member 42 "GO:0000209,GO:0004842,GO:0005515,GO:0005819,GO:0005829,GO:0007049,GO:0031463,GO:0032886,GO:0043161,GO:0043687,GO:0051301" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|spindle|cytosol|cell cycle|Cul3-RING ubiquitin ligase complex|regulation of microtubule-based process|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|cell division KLHL5 5080.298825 5693.144766 4467.452883 0.78470741 -0.349773271 0.145514549 1 27.31816873 21.07805412 51088 kelch like family member 5 "GO:0003674,GO:0003779,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0008150,GO:0043687" molecular_function|actin binding|protein binding|cytoplasm|cytosol|cytoskeleton|biological_process|post-translational protein modification KLHL7 1051.191501 975.9082219 1126.47478 1.154283523 0.206997632 0.398566449 1 7.558036303 8.57813049 55975 kelch like family member 7 "GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0016567,GO:0031463,GO:0042802,GO:0042803,GO:0048471" protein binding|nucleoplasm|nucleolus|cytosol|plasma membrane|protein ubiquitination|Cul3-RING ubiquitin ligase complex|identical protein binding|protein homodimerization activity|perinuclear region of cytoplasm KLHL8 449.7487184 477.5499721 421.9474647 0.883567143 -0.178588324 0.527571374 1 4.34543296 3.775233259 57563 kelch like family member 8 "GO:0005654,GO:0006511,GO:0016567,GO:0031463" nucleoplasm|ubiquitin-dependent protein catabolic process|protein ubiquitination|Cul3-RING ubiquitin ligase complex KLHL9 1245.234335 1250.577487 1239.891183 0.991454905 -0.01238094 0.962747534 1 11.62735575 11.33509344 55958 kelch like family member 9 "GO:0004842,GO:0005829,GO:0007049,GO:0016567,GO:0030496,GO:0031463,GO:0032465,GO:0043687,GO:0051301,GO:0097602" ubiquitin-protein transferase activity|cytosol|cell cycle|protein ubiquitination|midbody|Cul3-RING ubiquitin ligase complex|regulation of cytokinesis|post-translational protein modification|cell division|cullin family protein binding hsa04120 Ubiquitin mediated proteolysis KLK1 8.249083553 2.080827765 14.41733934 6.928655788 2.792575486 0.047253741 1 0.059800729 0.407405269 3816 kallikrein 1 "GO:0003073,GO:0004252,GO:0005634,GO:0030141,GO:0031638,GO:0070062" regulation of systemic arterial blood pressure|serine-type endopeptidase activity|nucleus|secretory granule|zymogen activation|extracellular exosome "hsa04614,hsa04961" Renin-angiotensin system|Endocrine and other factor-regulated calcium reabsorption KLLN 17.17185948 21.84869154 12.49502743 0.571889049 -0.806192815 0.388176961 1 0.266458983 0.149835018 100144748 "killin, p53 regulated DNA replication inhibitor" "GO:0003677,GO:0005654,GO:0005730,GO:0006915,GO:0007050" DNA binding|nucleoplasm|nucleolus|apoptotic process|cell cycle arrest KLRC1 13.45115297 12.48496659 14.41733934 1.154775965 0.207612985 0.912197108 1 0.283652499 0.322073898 3821 killer cell lectin like receptor C1 "GO:0001915,GO:0002305,GO:0002769,GO:0004888,GO:0005515,GO:0005886,GO:0005887,GO:0007166,GO:0023024,GO:0030246,GO:0043235,GO:0045953,GO:0050776,GO:0062082,GO:1990405" "negative regulation of T cell mediated cytotoxicity|CD8-positive, gamma-delta intraepithelial T cell differentiation|natural killer cell inhibitory signaling pathway|transmembrane signaling receptor activity|protein binding|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|MHC class I protein complex binding|carbohydrate binding|receptor complex|negative regulation of natural killer cell mediated cytotoxicity|regulation of immune response|HLA-E specific inhibitory MHC class Ib receptor activity|protein antigen binding" "hsa04612,hsa04650,hsa05332" Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Graft-versus-host disease KLRC2 56.07855403 71.7885579 40.36855015 0.562325687 -0.830522144 0.148862066 1 3.094687717 1.711102132 3822 killer cell lectin like receptor C2 "GO:0002223,GO:0002228,GO:0004888,GO:0005515,GO:0005886,GO:0005887,GO:0006968,GO:0007165,GO:0023024,GO:0030246,GO:0043235,GO:0043323,GO:0045087,GO:0045954,GO:0062081,GO:1990405" stimulatory C-type lectin receptor signaling pathway|natural killer cell mediated immunity|transmembrane signaling receptor activity|protein binding|plasma membrane|integral component of plasma membrane|cellular defense response|signal transduction|MHC class I protein complex binding|carbohydrate binding|receptor complex|positive regulation of natural killer cell degranulation|innate immune response|positive regulation of natural killer cell mediated cytotoxicity|activating MHC class Ib receptor activity|protein antigen binding "hsa04612,hsa04650" Antigen processing and presentation|Natural killer cell mediated cytotoxicity KLRC3 29.33979437 38.49531366 20.18427508 0.524330708 -0.931451053 0.205754918 1 1.79425689 0.92504124 3823 killer cell lectin like receptor C3 "GO:0004888,GO:0006968,GO:0016021,GO:0030246" transmembrane signaling receptor activity|cellular defense response|integral component of membrane|carbohydrate binding "hsa04612,hsa04650" Antigen processing and presentation|Natural killer cell mediated cytotoxicity KLRC4 9.646158105 13.52538047 5.766935736 0.426378818 -1.229792327 0.308194169 1 0.777828338 0.326099821 8302 killer cell lectin like receptor C4 GO:0016021 integral component of membrane hsa04612 Antigen processing and presentation KLRC4-KLRK1 3.121241648 6.242483296 0 0 #NAME? 0.093640883 1 0.171109327 0 100528032 KLRC4-KLRK1 readthrough "GO:0002250,GO:0005515,GO:0005886,GO:0005887,GO:0007165,GO:0009897,GO:0009986,GO:0016021,GO:0030101,GO:0030154,GO:0030246,GO:0031295,GO:0034260,GO:0038023,GO:0042267,GO:0045954,GO:0050776,GO:2000502" adaptive immune response|protein binding|plasma membrane|integral component of plasma membrane|signal transduction|external side of plasma membrane|cell surface|integral component of membrane|natural killer cell activation|cell differentiation|carbohydrate binding|T cell costimulation|negative regulation of GTPase activity|signaling receptor activity|natural killer cell mediated cytotoxicity|positive regulation of natural killer cell mediated cytotoxicity|regulation of immune response|negative regulation of natural killer cell chemotaxis "hsa04650,hsa05144" Natural killer cell mediated cytotoxicity|Malaria KLRG1 4.003139677 4.161655531 3.844623824 0.923820772 -0.11431511 1 1 0.065535529 0.059529976 10219 killer cell lectin like receptor G1 "GO:0005515,GO:0005886,GO:0006954,GO:0006968,GO:0007166,GO:0016021,GO:0030246,GO:0038023,GO:0043231,GO:0045087" protein binding|plasma membrane|inflammatory response|cellular defense response|cell surface receptor signaling pathway|integral component of membrane|carbohydrate binding|signaling receptor activity|intracellular membrane-bounded organelle|innate immune response KMT2A 4406.200677 5015.835328 3796.566026 0.756916003 -0.401794886 0.092766197 1 18.34470345 13.65304625 4297 lysine methyltransferase 2A "GO:0003680,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006915,GO:0008270,GO:0032411,GO:0032922,GO:0035097,GO:0035162,GO:0042800,GO:0042802,GO:0042803,GO:0043984,GO:0044648,GO:0045322,GO:0045652,GO:0045893,GO:0045944,GO:0051568,GO:0051571,GO:0065003,GO:0070577,GO:0071339,GO:0071440,GO:0080182,GO:0097692,GO:1902036,GO:1905642,GO:2000615" "minor groove of adenine-thymine-rich DNA binding|protein binding|nucleus|nucleoplasm|cytosol|apoptotic process|zinc ion binding|positive regulation of transporter activity|circadian regulation of gene expression|histone methyltransferase complex|embryonic hemopoiesis|histone methyltransferase activity (H3-K4 specific)|identical protein binding|protein homodimerization activity|histone H4-K16 acetylation|histone H3-K4 dimethylation|unmethylated CpG binding|regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|histone H3-K4 methylation|positive regulation of histone H3-K4 methylation|protein-containing complex assembly|lysine-acetylated histone binding|MLL1 complex|regulation of histone H3-K14 acetylation|histone H3-K4 trimethylation|histone H3-K4 monomethylation|regulation of hematopoietic stem cell differentiation|negative regulation of DNA methylation|regulation of histone H3-K9 acetylation" "hsa00310,hsa04934,hsa05202" Lysine degradation|Cushing syndrome|Transcriptional misregulation in cancer other KMT2B 719.1580065 762.623376 675.6926371 0.886010918 -0.174603619 0.495823362 1 4.64556648 4.047146555 9757 lysine methyltransferase 2B "GO:0005515,GO:0005634,GO:0005654,GO:0008270,GO:0035097,GO:0042800,GO:0044648,GO:0045322,GO:0045652,GO:0045893,GO:0051568,GO:0097692" "protein binding|nucleus|nucleoplasm|zinc ion binding|histone methyltransferase complex|histone methyltransferase activity (H3-K4 specific)|histone H3-K4 dimethylation|unmethylated CpG binding|regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-templated|histone H3-K4 methylation|histone H3-K4 monomethylation" hsa00310 Lysine degradation other KMT2C 1404.754813 1527.32758 1282.182045 0.839493808 -0.252408412 0.292049489 1 4.630235504 3.822009448 58508 lysine methyltransferase 2C "GO:0003677,GO:0003713,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0016746,GO:0035097,GO:0042054,GO:0042393,GO:0042800,GO:0044666,GO:0045652,GO:0045944,GO:0046872,GO:0097692" "DNA binding|transcription coactivator activity|RNA binding|protein binding|nucleus|nucleoplasm|transferase activity, transferring acyl groups|histone methyltransferase complex|histone methyltransferase activity|histone binding|histone methyltransferase activity (H3-K4 specific)|MLL3/4 complex|regulation of megakaryocyte differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|histone H3-K4 monomethylation" hsa00310 Lysine degradation KMT2D 2481.6384 2748.773478 2214.503323 0.805633254 -0.31180486 0.187159328 1 7.088523242 5.61518838 8085 lysine methyltransferase 2D "GO:0000976,GO:0001555,GO:0003677,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006342,GO:0006355,GO:0008284,GO:0033148,GO:0035097,GO:0042393,GO:0042800,GO:0043627,GO:0044648,GO:0044666,GO:0045652,GO:0045944,GO:0046872,GO:0048477,GO:0051568,GO:0080182,GO:0097692,GO:1904837" "transcription regulatory region sequence-specific DNA binding|oocyte growth|DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|chromatin silencing|regulation of transcription, DNA-templated|positive regulation of cell population proliferation|positive regulation of intracellular estrogen receptor signaling pathway|histone methyltransferase complex|histone binding|histone methyltransferase activity (H3-K4 specific)|response to estrogen|histone H3-K4 dimethylation|MLL3/4 complex|regulation of megakaryocyte differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|oogenesis|histone H3-K4 methylation|histone H3-K4 trimethylation|histone H3-K4 monomethylation|beta-catenin-TCF complex assembly" "hsa00310,hsa04934" Lysine degradation|Cushing syndrome other KMT2E 1630.386845 1823.845536 1436.928154 0.787856277 -0.343995622 0.147998445 1 9.652447856 7.477486581 55904 lysine methyltransferase 2E (inactive) "GO:0000785,GO:0002446,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005815,GO:0005886,GO:0006306,GO:0007050,GO:0016604,GO:0016607,GO:0018024,GO:0019899,GO:0030218,GO:0032991,GO:0034968,GO:0035064,GO:0035327,GO:0042119,GO:0045652,GO:0045893,GO:0046872,GO:1900087,GO:1905437" "chromatin|neutrophil mediated immunity|protein binding|nucleus|nucleoplasm|cytoplasm|microtubule organizing center|plasma membrane|DNA methylation|cell cycle arrest|nuclear body|nuclear speck|histone-lysine N-methyltransferase activity|enzyme binding|erythrocyte differentiation|protein-containing complex|histone lysine methylation|methylated histone binding|transcriptionally active chromatin|neutrophil activation|regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-templated|metal ion binding|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of histone H3-K4 trimethylation" hsa00310 Lysine degradation KMT5A 1507.890379 1598.075724 1417.705035 0.887132577 -0.172778371 0.469711083 1 26.61871543 23.21917579 387893 lysine methyltransferase 5A "GO:0000122,GO:0002039,GO:0003714,GO:0005515,GO:0005654,GO:0005694,GO:0005829,GO:0007049,GO:0016278,GO:0016279,GO:0018024,GO:0018026,GO:0034770,GO:0042799,GO:0043516,GO:0045892,GO:0051301,GO:1901796" "negative regulation of transcription by RNA polymerase II|p53 binding|transcription corepressor activity|protein binding|nucleoplasm|chromosome|cytosol|cell cycle|lysine N-methyltransferase activity|protein-lysine N-methyltransferase activity|histone-lysine N-methyltransferase activity|peptidyl-lysine monomethylation|histone H4-K20 methylation|histone methyltransferase activity (H4-K20 specific)|regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription, DNA-templated|cell division|regulation of signal transduction by p53 class mediator" hsa00310 Lysine degradation KMT5B 757.1632957 763.6637899 750.6628016 0.982975508 -0.024772625 0.927588585 1 5.562349244 5.376159303 51111 lysine methyltransferase 5B "GO:0000779,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0007517,GO:0018024,GO:0034773,GO:0042799,GO:0045830,GO:0046872,GO:1904047,GO:2001034" "condensed chromosome, centromeric region|chromatin binding|protein binding|nucleus|nucleoplasm|DNA repair|muscle organ development|histone-lysine N-methyltransferase activity|histone H4-K20 trimethylation|histone methyltransferase activity (H4-K20 specific)|positive regulation of isotype switching|metal ion binding|S-adenosyl-L-methionine binding|positive regulation of double-strand break repair via nonhomologous end joining" hsa00310 Lysine degradation KMT5C 147.1650729 129.0113214 165.3188244 1.281428812 0.357753334 0.385313631 1 2.172640301 2.737496007 84787 lysine methyltransferase 5C "GO:0000779,GO:0000792,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005721,GO:0006281,GO:0034773,GO:0042393,GO:0042799,GO:0045830,GO:0046872,GO:1904047,GO:2001034" "condensed chromosome, centromeric region|heterochromatin|chromatin binding|protein binding|nucleus|nucleoplasm|pericentric heterochromatin|DNA repair|histone H4-K20 trimethylation|histone binding|histone methyltransferase activity (H4-K20 specific)|positive regulation of isotype switching|metal ion binding|S-adenosyl-L-methionine binding|positive regulation of double-strand break repair via nonhomologous end joining" hsa00310 Lysine degradation KNDC1 4.483717655 4.161655531 4.80577978 1.154775965 0.207612985 1 1 0.021388666 0.024285811 85442 kinase non-catalytic C-lobe domain containing 1 "GO:0001934,GO:0003674,GO:0005575,GO:0007264,GO:0008150,GO:0021707,GO:0030425,GO:0032045,GO:0043025,GO:0043204,GO:0048814,GO:0050773,GO:0050790" positive regulation of protein phosphorylation|molecular_function|cellular_component|small GTPase mediated signal transduction|biological_process|cerebellar granule cell differentiation|dendrite|guanyl-nucleotide exchange factor complex|neuronal cell body|perikaryon|regulation of dendrite morphogenesis|regulation of dendrite development|regulation of catalytic activity KNL1 1574.967507 1706.278768 1443.656246 0.846084634 -0.241126112 0.311445167 1 9.504327504 7.90690242 57082 kinetochore scaffold 1 "GO:0000777,GO:0001669,GO:0001675,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0008608,GO:0010923,GO:0016604,GO:0034080,GO:0034501,GO:0051301" condensed chromosome kinetochore|acrosomal vesicle|acrosome assembly|protein binding|nucleus|nucleoplasm|cytosol|attachment of spindle microtubules to kinetochore|negative regulation of phosphatase activity|nuclear body|CENP-A containing nucleosome assembly|protein localization to kinetochore|cell division KNOP1 582.7191345 650.2586767 515.1795924 0.792268694 -0.335938299 0.204038436 1 4.800540939 3.739674918 400506 lysine rich nucleolar protein 1 "GO:0003723,GO:0005515,GO:0005730" RNA binding|protein binding|nucleolus KNSTRN 1153.509337 1088.272921 1218.745752 1.119889807 0.163356784 0.502515851 1 28.56818773 31.457859 90417 kinetochore localized astrin (SPAG5) binding protein "GO:0000070,GO:0000226,GO:0000776,GO:0000777,GO:0000922,GO:0001726,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0007051,GO:0007059,GO:0016477,GO:0034451,GO:0035371,GO:0042803,GO:0051010,GO:0051301,GO:0051988,GO:0071364,GO:0072686" mitotic sister chromatid segregation|microtubule cytoskeleton organization|kinetochore|condensed chromosome kinetochore|spindle pole|ruffle|protein binding|nucleus|cytoplasm|plasma membrane|spindle organization|chromosome segregation|cell migration|centriolar satellite|microtubule plus-end|protein homodimerization activity|microtubule plus-end binding|cell division|regulation of attachment of spindle microtubules to kinetochore|cellular response to epidermal growth factor stimulus|mitotic spindle KNTC1 3110.438915 3334.526494 2886.351336 0.865595562 -0.208234992 0.379430582 1 23.66456787 20.14117386 9735 kinetochore associated 1 "GO:0000777,GO:0000922,GO:0005515,GO:0005634,GO:0005828,GO:0005829,GO:0005886,GO:0007094,GO:0007096,GO:0015629,GO:0051301,GO:0065003,GO:1990423" condensed chromosome kinetochore|spindle pole|protein binding|nucleus|kinetochore microtubule|cytosol|plasma membrane|mitotic spindle assembly checkpoint|regulation of exit from mitosis|actin cytoskeleton|cell division|protein-containing complex assembly|RZZ complex KPNA1 2194.910026 2210.879501 2178.940552 0.985553736 -0.02099356 0.931236404 1 13.53413346 13.11541213 3836 karyopherin subunit alpha 1 "GO:0000018,GO:0005515,GO:0005634,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0006309,GO:0006607,GO:0008139,GO:0014069,GO:0014841,GO:0014901,GO:0019054,GO:0030425,GO:0042981,GO:0043657,GO:0060828,GO:0061608,GO:0075733,GO:0098978,GO:0099527" regulation of DNA recombination|protein binding|nucleus|nuclear pore|nucleoplasm|cytoplasm|cytosol|apoptotic DNA fragmentation|NLS-bearing protein import into nucleus|nuclear localization sequence binding|postsynaptic density|skeletal muscle satellite cell proliferation|satellite cell activation involved in skeletal muscle regeneration|modulation by virus of host cellular process|dendrite|regulation of apoptotic process|host cell|regulation of canonical Wnt signaling pathway|nuclear import signal receptor activity|intracellular transport of virus|glutamatergic synapse|postsynapse to nucleus signaling pathway "hsa05132,hsa05164" Salmonella infection|Influenza A KPNA2 8270.598587 8916.346974 7624.850199 0.855154047 -0.225743765 0.361418642 1 184.867541 155.4448 3838 karyopherin subunit alpha 2 "GO:0000018,GO:0000139,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005789,GO:0005829,GO:0006259,GO:0006607,GO:0008139,GO:0016020,GO:0019054,GO:0042826,GO:0043657,GO:0061608,GO:0075506,GO:0098892,GO:0098978,GO:0099527,GO:1903902" regulation of DNA recombination|Golgi membrane|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum membrane|cytosol|DNA metabolic process|NLS-bearing protein import into nucleus|nuclear localization sequence binding|membrane|modulation by virus of host cellular process|histone deacetylase binding|host cell|nuclear import signal receptor activity|entry of viral genome into host nucleus through nuclear pore complex via importin|extrinsic component of postsynaptic specialization membrane|glutamatergic synapse|postsynapse to nucleus signaling pathway|positive regulation of viral life cycle hsa05164 Influenza A KPNA3 1508.173427 1491.953508 1524.393346 1.021743197 0.031032637 0.899287152 1 18.08787292 18.1719039 3839 karyopherin subunit alpha 3 "GO:0005515,GO:0005634,GO:0005643,GO:0005654,GO:0005829,GO:0006607,GO:0008022,GO:0008139,GO:0019054,GO:0043657,GO:0046718,GO:0061608,GO:0065003,GO:0075732" protein binding|nucleus|nuclear pore|nucleoplasm|cytosol|NLS-bearing protein import into nucleus|protein C-terminus binding|nuclear localization sequence binding|modulation by virus of host cellular process|host cell|viral entry into host cell|nuclear import signal receptor activity|protein-containing complex assembly|viral penetration into host nucleus hsa05132 Salmonella infection KPNA4 2605.078358 2620.80257 2589.354145 0.98800046 -0.017416381 0.942984817 1 15.62415285 15.17835844 3840 karyopherin subunit alpha 4 "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006607,GO:0008139,GO:0019054,GO:0031965,GO:0061608" protein binding|nucleus|nucleoplasm|cytosol|NLS-bearing protein import into nucleus|nuclear localization sequence binding|modulation by virus of host cellular process|nuclear membrane|nuclear import signal receptor activity hsa05132 Salmonella infection KPNA5 114.6096877 119.6475965 109.571779 0.915787548 -0.126915147 0.792539584 1 1.081167003 0.973550973 3841 karyopherin subunit alpha 5 "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006607,GO:0008139,GO:0019054,GO:0061608" protein binding|nucleus|nucleoplasm|cytosol|NLS-bearing protein import into nucleus|nuclear localization sequence binding|modulation by virus of host cellular process|nuclear import signal receptor activity hsa05164 Influenza A KPNA6 1780.13909 1793.673534 1766.604647 0.984908688 -0.021938118 0.928753735 1 11.28035115 10.92420311 23633 karyopherin subunit alpha 6 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006607,GO:0008139,GO:0016020,GO:0019079,GO:0030682,GO:0043657,GO:0045944,GO:0060135,GO:0061608,GO:0075506,GO:1900017,GO:1903902" protein binding|nucleus|nucleoplasm|cytoplasm|NLS-bearing protein import into nucleus|nuclear localization sequence binding|membrane|viral genome replication|mitigation of host defenses by symbiont|host cell|positive regulation of transcription by RNA polymerase II|maternal process involved in female pregnancy|nuclear import signal receptor activity|entry of viral genome into host nucleus through nuclear pore complex via importin|positive regulation of cytokine production involved in inflammatory response|positive regulation of viral life cycle hsa05164 Influenza A KPNA7 3.601819626 6.242483296 0.961155956 0.153970129 -2.699277611 0.237188726 1 0.085401143 0.012929191 402569 karyopherin subunit alpha 7 "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006607,GO:0008139,GO:0019054,GO:0061608" protein binding|nucleus|nucleoplasm|cytosol|NLS-bearing protein import into nucleus|nuclear localization sequence binding|modulation by virus of host cellular process|nuclear import signal receptor activity hsa05164 Influenza A KPNB1 9572.179931 9274.24935 9870.110512 1.064248991 0.089835722 0.719878604 1 77.70010086 81.30851105 3837 karyopherin subunit beta 1 "GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0006309,GO:0006606,GO:0006607,GO:0006610,GO:0007079,GO:0007080,GO:0008139,GO:0008270,GO:0010494,GO:0016020,GO:0019054,GO:0019899,GO:0019904,GO:0030953,GO:0031291,GO:0031965,GO:0035580,GO:0040001,GO:0043312,GO:0043657,GO:0045184,GO:0045540,GO:0061608,GO:0070062,GO:0071782,GO:0075733,GO:0090307,GO:1904813" RNA binding|protein binding|extracellular region|nucleus|nuclear envelope|nuclear pore|nucleoplasm|cytoplasm|cytosol|apoptotic DNA fragmentation|protein import into nucleus|NLS-bearing protein import into nucleus|ribosomal protein import into nucleus|mitotic chromosome movement towards spindle pole|mitotic metaphase plate congression|nuclear localization sequence binding|zinc ion binding|cytoplasmic stress granule|membrane|modulation by virus of host cellular process|enzyme binding|protein domain specific binding|astral microtubule organization|Ran protein signal transduction|nuclear membrane|specific granule lumen|establishment of mitotic spindle localization|neutrophil degranulation|host cell|establishment of protein localization|regulation of cholesterol biosynthetic process|nuclear import signal receptor activity|extracellular exosome|endoplasmic reticulum tubular network|intracellular transport of virus|mitotic spindle assembly|ficolin-1-rich granule lumen hsa03013 RNA transport KPTN 82.82234411 92.59683556 73.04785266 0.788880659 -0.342121027 0.502996122 1 1.865505069 1.447034617 11133 "kaptin, actin binding protein" "GO:0005765,GO:0007015,GO:0030027,GO:0031941,GO:0032420,GO:0034198,GO:0042149,GO:0051015,GO:0061462,GO:0098871,GO:0140007,GO:1904262" lysosomal membrane|actin filament organization|lamellipodium|filamentous actin|stereocilium|cellular response to amino acid starvation|cellular response to glucose starvation|actin filament binding|protein localization to lysosome|postsynaptic actin cytoskeleton|KICSTOR complex|negative regulation of TORC1 signaling KRAS 1823.925792 1858.179194 1789.67239 0.963132294 -0.054194117 0.821110003 1 18.26291131 17.29526154 3845 "KRAS proto-oncogene, GTPase" "GO:0000165,GO:0001889,GO:0001934,GO:0002223,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0005925,GO:0007265,GO:0007565,GO:0008284,GO:0008542,GO:0010628,GO:0016020,GO:0019002,GO:0019003,GO:0019221,GO:0021897,GO:0030036,GO:0030275,GO:0031234,GO:0031647,GO:0032228,GO:0035022,GO:0035900,GO:0038002,GO:0043406,GO:0043524,GO:0044877,GO:0045121,GO:0045596,GO:0048169,GO:0048873,GO:0051000,GO:0051092,GO:0051146,GO:0051384,GO:0051385,GO:0060441,GO:2000774" "MAPK cascade|liver development|positive regulation of protein phosphorylation|stimulatory C-type lectin receptor signaling pathway|GTPase activity|protein binding|GTP binding|cytoplasm|mitochondrion|cytosol|plasma membrane|focal adhesion|Ras protein signal transduction|female pregnancy|positive regulation of cell population proliferation|visual learning|positive regulation of gene expression|membrane|GMP binding|GDP binding|cytokine-mediated signaling pathway|forebrain astrocyte development|actin cytoskeleton organization|LRR domain binding|extrinsic component of cytoplasmic side of plasma membrane|regulation of protein stability|regulation of synaptic transmission, GABAergic|positive regulation of Rac protein signal transduction|response to isolation stress|endocrine signaling|positive regulation of MAP kinase activity|negative regulation of neuron apoptotic process|protein-containing complex binding|membrane raft|negative regulation of cell differentiation|regulation of long-term neuronal synaptic plasticity|homeostasis of number of cells within a tissue|positive regulation of nitric-oxide synthase activity|positive regulation of NF-kappaB transcription factor activity|striated muscle cell differentiation|response to glucocorticoid|response to mineralocorticoid|epithelial tube branching involved in lung morphogenesis|positive regulation of cellular senescence" "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04062,hsa04068,hsa04071,hsa04072,hsa04137,hsa04140,hsa04150,hsa04151,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04371,hsa04540,hsa04550,hsa04625,hsa04650,hsa04660,hsa04662,hsa04664,hsa04714,hsa04720,hsa04722,hsa04725,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04914,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04929,hsa04933,hsa04935,hsa04960,hsa05010,hsa05022,hsa05034,hsa05160,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05170,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Mitophagy - animal|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Apelin signaling pathway|Gap junction|Signaling pathways regulating pluripotency of stem cells|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|GnRH secretion|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" KRBA1 223.4625006 214.3252598 232.5997414 1.085265178 0.1180476 0.745034309 1 2.752200482 2.936886167 84626 KRAB-A domain containing 1 "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process KRBA2 84.42259389 96.75849109 72.0866967 0.745016751 -0.424655231 0.39800714 1 0.409762167 0.300171237 124751 KRAB-A domain containing 2 "GO:0003676,GO:0005515,GO:0006355,GO:0015074" "nucleic acid binding|protein binding|regulation of transcription, DNA-templated|DNA integration" KRBOX4 291.6693605 301.720026 281.6186951 0.933377538 -0.099467346 0.762668111 1 6.814322153 6.25390364 55634 KRAB box domain containing 4 GO:0006355 "regulation of transcription, DNA-templated" KRCC1 36.18677295 41.61655531 30.75699059 0.739056617 -0.436243205 0.53600437 1 1.042722567 0.757735547 51315 lysine rich coiled-coil 1 GO:0005515 protein binding KREMEN1 710.7610823 630.4908129 791.0313518 1.25462788 0.327259527 0.200710409 1 3.533725676 4.359321955 83999 kringle containing transmembrane protein 1 "GO:0005515,GO:0005886,GO:0006915,GO:0007154,GO:0016020,GO:0016021,GO:0016055,GO:0030279,GO:0043025,GO:0048681,GO:0060173,GO:0060828,GO:0090090" protein binding|plasma membrane|apoptotic process|cell communication|membrane|integral component of membrane|Wnt signaling pathway|negative regulation of ossification|neuronal cell body|negative regulation of axon regeneration|limb development|regulation of canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway KREMEN2 60.65159045 53.06110801 68.24207288 1.286103427 0.363006668 0.529061368 1 1.419435495 1.794992901 79412 kringle containing transmembrane protein 2 "GO:0005886,GO:0016021,GO:0016055,GO:0030279,GO:0031901,GO:0060173,GO:0090090" plasma membrane|integral component of membrane|Wnt signaling pathway|negative regulation of ossification|early endosome membrane|limb development|negative regulation of canonical Wnt signaling pathway KRI1 640.2891123 698.1177153 582.4605093 0.834329937 -0.261310083 0.315382325 1 12.46479069 10.22572233 65095 KRI1 homolog "GO:0000447,GO:0003723,GO:0005730,GO:0030686" "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleolus|90S preribosome" KRIT1 668.4104696 679.3902654 657.4306739 0.967677501 -0.047401777 0.859754882 1 7.148621805 6.801804475 889 KRIT1 ankyrin repeat containing "GO:0001525,GO:0001937,GO:0005515,GO:0005546,GO:0005615,GO:0005737,GO:0005856,GO:0005886,GO:0005911,GO:0007264,GO:0008017,GO:0010596,GO:0016525,GO:0030695,GO:0045454,GO:0050790,GO:2000114,GO:2000352" "angiogenesis|negative regulation of endothelial cell proliferation|protein binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular space|cytoplasm|cytoskeleton|plasma membrane|cell-cell junction|small GTPase mediated signal transduction|microtubule binding|negative regulation of endothelial cell migration|negative regulation of angiogenesis|GTPase regulator activity|cell redox homeostasis|regulation of catalytic activity|regulation of establishment of cell polarity|negative regulation of endothelial cell apoptotic process" hsa04015 Rap1 signaling pathway KRR1 1768.234081 1720.844562 1815.623601 1.055077048 0.077348357 0.746102348 1 9.089302404 9.429440122 11103 KRR1 small subunit processome component homolog "GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0006364,GO:0016020,GO:0032040,GO:0045171" RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|cytoplasm|rRNA processing|membrane|small-subunit processome|intercellular bridge KRT10 233.232576 218.4869154 247.9782366 1.134979805 0.182666628 0.601691852 1 5.390774439 6.016036648 3858 keratin 10 "GO:0001533,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005882,GO:0009986,GO:0016020,GO:0018149,GO:0030216,GO:0030280,GO:0031424,GO:0045684,GO:0046982,GO:0051290,GO:0070062,GO:0070268" cornified envelope|protein binding|extracellular space|nucleus|cytoplasm|cytosol|intermediate filament|cell surface|membrane|peptide cross-linking|keratinocyte differentiation|structural constituent of skin epidermis|keratinization|positive regulation of epidermis development|protein heterodimerization activity|protein heterotetramerization|extracellular exosome|cornification "hsa04915,hsa05150" Estrogen signaling pathway|Staphylococcus aureus infection KRT15 372.9216374 315.2454064 430.5978683 1.36591322 0.449865829 0.127233018 1 8.441579501 11.33751832 3866 keratin 15 "GO:0005200,GO:0005515,GO:0005634,GO:0005829,GO:0005882,GO:0007010,GO:0008544,GO:0031424,GO:0070062,GO:0070268,GO:0097110" structural constituent of cytoskeleton|protein binding|nucleus|cytosol|intermediate filament|cytoskeleton organization|epidermis development|keratinization|extracellular exosome|cornification|scaffold protein binding "hsa04915,hsa05150" Estrogen signaling pathway|Staphylococcus aureus infection KRT17 5.925451589 4.161655531 7.689247648 1.847641543 0.88568489 0.619277139 1 0.146407322 0.26598166 3872 keratin 17 "GO:0005198,GO:0005515,GO:0005829,GO:0005882,GO:0030307,GO:0031069,GO:0031424,GO:0045109,GO:0045111,GO:0045727,GO:0051798,GO:0070268,GO:0071944" structural molecule activity|protein binding|cytosol|intermediate filament|positive regulation of cell growth|hair follicle morphogenesis|keratinization|intermediate filament organization|intermediate filament cytoskeleton|positive regulation of translation|positive regulation of hair follicle development|cornification|cell periphery "hsa04915,hsa05150" Estrogen signaling pathway|Staphylococcus aureus infection KRT18 11537.76802 11003.41722 12072.11881 1.097124517 0.133727272 0.599798727 1 392.2726478 423.1702477 3875 keratin 18 "GO:0003723,GO:0005198,GO:0005515,GO:0005730,GO:0005737,GO:0005815,GO:0005829,GO:0005882,GO:0005912,GO:0007049,GO:0009653,GO:0009750,GO:0009897,GO:0016032,GO:0031424,GO:0031667,GO:0032991,GO:0033209,GO:0034451,GO:0043000,GO:0043066,GO:0045095,GO:0045104,GO:0048471,GO:0070062,GO:0070268,GO:0070365,GO:0072497,GO:0097110,GO:0097191,GO:0097284,GO:0098609,GO:0098641,GO:1902488" RNA binding|structural molecule activity|protein binding|nucleolus|cytoplasm|microtubule organizing center|cytosol|intermediate filament|adherens junction|cell cycle|anatomical structure morphogenesis|response to fructose|external side of plasma membrane|viral process|keratinization|response to nutrient levels|protein-containing complex|tumor necrosis factor-mediated signaling pathway|centriolar satellite|Golgi to plasma membrane CFTR protein transport|negative regulation of apoptotic process|keratin filament|intermediate filament cytoskeleton organization|perinuclear region of cytoplasm|extracellular exosome|cornification|hepatocyte differentiation|mesenchymal stem cell differentiation|scaffold protein binding|extrinsic apoptotic signaling pathway|hepatocyte apoptotic process|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|cholangiocyte apoptotic process "hsa04915,hsa05150" Estrogen signaling pathway|Staphylococcus aureus infection KRT19 106.2568086 76.99062732 135.5229898 1.760253092 0.815782877 0.075455448 1 2.956005955 5.116248132 3880 keratin 19 "GO:0005200,GO:0005515,GO:0005829,GO:0005882,GO:0005886,GO:0007219,GO:0008307,GO:0016010,GO:0016032,GO:0016327,GO:0030018,GO:0031424,GO:0042383,GO:0043034,GO:0043627,GO:0044877,GO:0045214,GO:0060706,GO:0070062,GO:0070268,GO:0071944,GO:1990357" structural constituent of cytoskeleton|protein binding|cytosol|intermediate filament|plasma membrane|Notch signaling pathway|structural constituent of muscle|dystrophin-associated glycoprotein complex|viral process|apicolateral plasma membrane|Z disc|keratinization|sarcolemma|costamere|response to estrogen|protein-containing complex binding|sarcomere organization|cell differentiation involved in embryonic placenta development|extracellular exosome|cornification|cell periphery|terminal web "hsa04915,hsa05150" Estrogen signaling pathway|Staphylococcus aureus infection KRT222 50.04427638 39.53572754 60.55282523 1.531597595 0.6150373 0.310265285 1 0.780595307 1.175551853 125113 keratin 222 "GO:0005198,GO:0005515,GO:0005882" structural molecule activity|protein binding|intermediate filament KRT23 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.090394752 0.041055574 25984 keratin 23 "GO:0005198,GO:0005515,GO:0005829,GO:0005882,GO:0031424,GO:0070268" structural molecule activity|protein binding|cytosol|intermediate filament|keratinization|cornification "hsa04915,hsa05150" Estrogen signaling pathway|Staphylococcus aureus infection KRT32 2.080827765 4.161655531 0 0 #NAME? 0.234194363 1 0.110773021 0 3882 keratin 32 "GO:0005198,GO:0005515,GO:0005829,GO:0005882,GO:0008544,GO:0031424,GO:0070062,GO:0070268" structural molecule activity|protein binding|cytosol|intermediate filament|epidermis development|keratinization|extracellular exosome|cornification "hsa04915,hsa05150" Estrogen signaling pathway|Staphylococcus aureus infection KRT33B 7.367185523 4.161655531 10.57271552 2.540507122 1.345116509 0.341208165 1 0.137438061 0.343319614 3884 keratin 33B "GO:0005198,GO:0005515,GO:0005615,GO:0005829,GO:0005882,GO:0007568,GO:0031424,GO:0042633,GO:0070062,GO:0070268" structural molecule activity|protein binding|extracellular space|cytosol|intermediate filament|aging|keratinization|hair cycle|extracellular exosome|cornification "hsa04915,hsa05150" Estrogen signaling pathway|Staphylococcus aureus infection KRT34 166.4573891 156.0620824 176.8526959 1.133220147 0.180428156 0.653497132 1 4.497163341 5.010996822 3885 keratin 34 "GO:0005198,GO:0005515,GO:0005615,GO:0005829,GO:0005882,GO:0008544,GO:0031424,GO:0070268" structural molecule activity|protein binding|extracellular space|cytosol|intermediate filament|epidermis development|keratinization|cornification "hsa04915,hsa05150" Estrogen signaling pathway|Staphylococcus aureus infection KRT39 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.086364336 390792 keratin 39 "GO:0005198,GO:0005515,GO:0005829,GO:0005882,GO:0031424,GO:0070268" structural molecule activity|protein binding|cytosol|intermediate filament|keratinization|cornification "hsa04915,hsa05150" Estrogen signaling pathway|Staphylococcus aureus infection KRT7 13717.42408 13104.01285 14330.8353 1.09362189 0.129114026 0.619160057 1 262.5139196 282.2868904 3855 keratin 7 "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005882,GO:0016032,GO:0031424,GO:0045095,GO:0070062,GO:0070268" protein binding|nucleus|cytoplasm|cytosol|intermediate filament|viral process|keratinization|keratin filament|extracellular exosome|cornification KRT8 12738.43424 11146.99434 14329.87415 1.285537044 0.362371183 0.159719822 1 299.2427568 378.2504221 3856 keratin 8 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005882,GO:0005911,GO:0016010,GO:0016032,GO:0016327,GO:0016363,GO:0030018,GO:0031424,GO:0033209,GO:0042383,GO:0043034,GO:0044877,GO:0045095,GO:0045111,GO:0045214,GO:0051599,GO:0051707,GO:0060706,GO:0070062,GO:0070268,GO:0097110,GO:0097191,GO:0097284" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|intermediate filament|cell-cell junction|dystrophin-associated glycoprotein complex|viral process|apicolateral plasma membrane|nuclear matrix|Z disc|keratinization|tumor necrosis factor-mediated signaling pathway|sarcolemma|costamere|protein-containing complex binding|keratin filament|intermediate filament cytoskeleton|sarcomere organization|response to hydrostatic pressure|response to other organism|cell differentiation involved in embryonic placenta development|extracellular exosome|cornification|scaffold protein binding|extrinsic apoptotic signaling pathway|hepatocyte apoptotic process KRT80 1790.498685 2620.80257 960.1948 0.366374335 -1.448609649 2.07E-09 3.14E-06 32.03559697 11.5406174 144501 keratin 80 "GO:0005515,GO:0005829,GO:0031424,GO:0045095,GO:0045111,GO:0070268" protein binding|cytosol|keratinization|keratin filament|intermediate filament cytoskeleton|cornification KRT81 166.5215558 195.5978099 137.4453017 0.702693459 -0.509032625 0.191978391 1 5.411454444 3.738962389 3887 keratin 81 "GO:0005515,GO:0005615,GO:0005829,GO:0031424,GO:0045095,GO:0070268" protein binding|extracellular space|cytosol|keratinization|keratin filament|cornification KRT86 51.83261015 73.86938567 29.79583464 0.403358365 -1.309865919 0.027758754 0.877967194 0.602057628 0.238781299 3892 keratin 86 "GO:0005515,GO:0005615,GO:0005829,GO:0031424,GO:0045095,GO:0070268" protein binding|extracellular space|cytosol|keratinization|keratin filament|cornification KRTAP1-5 4.562975582 6.242483296 2.883467868 0.461910386 -1.11431511 0.584550016 1 0.281614421 0.127903903 83895 keratin associated protein 1-5 "GO:0003674,GO:0005515,GO:0005575,GO:0005829,GO:0008150,GO:0031424,GO:0045095" molecular_function|protein binding|cellular_component|cytosol|biological_process|keratinization|keratin filament KRTAP2-3 558.2416833 272.5884373 843.8949294 3.095857395 1.630339018 2.79E-09 3.82E-06 16.62576446 50.60969844 730755 keratin associated protein 2-3 "GO:0005515,GO:0005829,GO:0031424,GO:0045095" protein binding|cytosol|keratinization|keratin filament KRTAP2-4 7.367185523 4.161655531 10.57271552 2.540507122 1.345116509 0.341208165 1 0.290706684 0.726183895 85294 keratin associated protein 2-4 "GO:0005515,GO:0005829,GO:0031424,GO:0045095" protein binding|cytosol|keratinization|keratin filament KRTAP4-7 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.118390142 0.161311639 100132476 keratin associated protein 4-7 KRTAP4-8 1.922311912 0 3.844623824 Inf Inf 0.288176591 1 0 0.173620559 728224 keratin associated protein 4-8 "GO:0005829,GO:0007568,GO:0031424,GO:0042633,GO:0045095" cytosol|aging|keratinization|hair cycle|keratin filament KRTAP4-9 37.79708357 20.80827765 54.78588949 2.632889199 1.396646809 0.038166586 0.982059825 1.009545031 2.613541841 100132386 keratin associated protein 4-9 "GO:0005829,GO:0007568,GO:0031424,GO:0042633,GO:0045095" cytosol|aging|keratinization|hair cycle|keratin filament KRTCAP2 865.4216741 842.7352449 888.1081033 1.053839991 0.075655834 0.765300673 1 85.99470581 89.10817909 200185 keratinocyte associated protein 2 "GO:0006487,GO:0008047,GO:0008250,GO:0016021,GO:0042543,GO:0050790" protein N-linked glycosylation|enzyme activator activity|oligosaccharyltransferase complex|integral component of membrane|protein N-linked glycosylation via arginine|regulation of catalytic activity KRTCAP3 11.96979007 11.44455271 12.49502743 1.091788185 0.12669299 0.995605371 1 0.580032995 0.622676202 200634 keratinocyte associated protein 3 "GO:0005515,GO:0016021" protein binding|integral component of membrane KSR1 117.498186 107.1626299 127.8337421 1.192894783 0.254466798 0.575023028 1 0.549013401 0.643956103 8844 kinase suppressor of ras 1 "GO:0000165,GO:0000185,GO:0004672,GO:0005078,GO:0005515,GO:0005524,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0006468,GO:0007165,GO:0007265,GO:0008022,GO:0016020,GO:0019933,GO:0032587,GO:0032991,GO:0042127,GO:0043405,GO:0043410,GO:0046872,GO:0071889,GO:0106310,GO:0106311" MAPK cascade|activation of MAPKKK activity|protein kinase activity|MAP-kinase scaffold activity|protein binding|ATP binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|protein phosphorylation|signal transduction|Ras protein signal transduction|protein C-terminus binding|membrane|cAMP-mediated signaling|ruffle membrane|protein-containing complex|regulation of cell population proliferation|regulation of MAP kinase activity|positive regulation of MAPK cascade|metal ion binding|14-3-3 protein binding|protein serine kinase activity|protein threonine kinase activity "hsa04014,hsa04625,hsa05152" Ras signaling pathway|C-type lectin receptor signaling pathway|Tuberculosis KTI12 241.9175781 232.0122958 251.8228605 1.085385839 0.118207992 0.736647649 1 7.249455391 7.736788266 112970 KTI12 chromatin associated homolog "GO:0002098,GO:0005515,GO:0005524,GO:0006357,GO:0033588" tRNA wobble uridine modification|protein binding|ATP binding|regulation of transcription by RNA polymerase II|elongator holoenzyme complex KTN1 4736.467803 4842.08621 4630.849396 0.956374834 -0.064351927 0.788800999 1 22.71165773 21.35738875 3895 kinectin 1 "GO:0003723,GO:0005515,GO:0005783,GO:0005788,GO:0005789,GO:0005887,GO:0007018,GO:0015031,GO:0016020,GO:0016021,GO:0019894,GO:0030176,GO:0043687,GO:0044267,GO:0045296" RNA binding|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral component of plasma membrane|microtubule-based movement|protein transport|membrane|integral component of membrane|kinesin binding|integral component of endoplasmic reticulum membrane|post-translational protein modification|cellular protein metabolic process|cadherin binding KXD1 1705.139358 1767.663187 1642.615529 0.92925821 -0.105848565 0.657158453 1 31.01148437 28.33545167 79036 KxDL motif containing 1 "GO:0005515,GO:0005765,GO:0016192,GO:0031083,GO:0032418,GO:0099078" protein binding|lysosomal membrane|vesicle-mediated transport|BLOC-1 complex|lysosome localization|BORC complex KYAT1 434.8017257 400.5593448 469.0441065 1.170972822 0.227707592 0.423191411 1 4.965648324 5.71733912 883 kynurenine aminotransferase 1 "GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0006559,GO:0006569,GO:0006575,GO:0008483,GO:0008652,GO:0016212,GO:0030170,GO:0042803,GO:0047316,GO:0047804,GO:0070189,GO:0097053" protein binding|cytoplasm|mitochondrion|cytosol|L-phenylalanine catabolic process|tryptophan catabolic process|cellular modified amino acid metabolic process|transaminase activity|cellular amino acid biosynthetic process|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding|protein homodimerization activity|glutamine-phenylpyruvate transaminase activity|cysteine-S-conjugate beta-lyase activity|kynurenine metabolic process|L-kynurenine catabolic process "hsa00270,hsa00380,hsa00450,hsa05204" Cysteine and methionine metabolism|Tryptophan metabolism|Selenocompound metabolism|Chemical carcinogenesis KYAT3 833.2336248 716.8451651 949.6220845 1.324724126 0.405691949 0.105256512 1 18.64362035 24.28437188 56267 kynurenine aminotransferase 3 "GO:0003723,GO:0005737,GO:0005739,GO:0006103,GO:0006520,GO:0009058,GO:0016212,GO:0030170,GO:0042803,GO:0047315,GO:0047804,GO:0070189,GO:0097052" RNA binding|cytoplasm|mitochondrion|2-oxoglutarate metabolic process|cellular amino acid metabolic process|biosynthetic process|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding|protein homodimerization activity|kynurenine-glyoxylate transaminase activity|cysteine-S-conjugate beta-lyase activity|kynurenine metabolic process|L-kynurenine metabolic process "hsa00270,hsa00380,hsa00450,hsa05204" Cysteine and methionine metabolism|Tryptophan metabolism|Selenocompound metabolism|Chemical carcinogenesis KYNU 435.0929909 572.2276355 297.9583464 0.52069898 -0.941478513 0.000917203 0.192965399 10.2824031 5.264444253 8942 kynureninase "GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006569,GO:0007568,GO:0009435,GO:0019441,GO:0019442,GO:0019805,GO:0030170,GO:0030429,GO:0034341,GO:0034354,GO:0034516,GO:0042803,GO:0043420,GO:0061981,GO:0097053" nucleoplasm|cytoplasm|mitochondrion|cytosol|tryptophan catabolic process|aging|NAD biosynthetic process|tryptophan catabolic process to kynurenine|tryptophan catabolic process to acetyl-CoA|quinolinate biosynthetic process|pyridoxal phosphate binding|kynureninase activity|response to interferon-gamma|'de novo' NAD biosynthetic process from tryptophan|response to vitamin B6|protein homodimerization activity|anthranilate metabolic process|3-hydroxykynureninase activity|L-kynurenine catabolic process hsa00380 Tryptophan metabolism L1CAM 4423.596947 3983.744757 4863.449137 1.22082348 0.287854615 0.228352029 1 40.8071278 48.98465799 3897 L1 cell adhesion molecule "GO:0005515,GO:0005886,GO:0005925,GO:0006935,GO:0007155,GO:0007156,GO:0007160,GO:0007399,GO:0007411,GO:0008046,GO:0009986,GO:0016021,GO:0016477,GO:0019904,GO:0030424,GO:0030425,GO:0031175,GO:0043025,GO:0044295,GO:0045773,GO:0050808,GO:0050900,GO:0061564,GO:0062023" protein binding|plasma membrane|focal adhesion|chemotaxis|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-matrix adhesion|nervous system development|axon guidance|axon guidance receptor activity|cell surface|integral component of membrane|cell migration|protein domain specific binding|axon|dendrite|neuron projection development|neuronal cell body|axonal growth cone|positive regulation of axon extension|synapse organization|leukocyte migration|axon development|collagen-containing extracellular matrix "hsa04360,hsa04514" Axon guidance|Cell adhesion molecules L2HGDH 342.2388743 329.8112008 354.6665478 1.075362349 0.104822866 0.736272333 1 2.46242552 2.603689004 79944 L-2-hydroxyglutarate dehydrogenase "GO:0003973,GO:0005739,GO:0005743,GO:0006103,GO:0016021,GO:0031305,GO:0044267,GO:0047545,GO:0055114" (S)-2-hydroxy-acid oxidase activity|mitochondrion|mitochondrial inner membrane|2-oxoglutarate metabolic process|integral component of membrane|integral component of mitochondrial inner membrane|cellular protein metabolic process|2-hydroxyglutarate dehydrogenase activity|oxidation-reduction process hsa00650 Butanoate metabolism L3HYPDH 397.6336751 408.8826559 386.3846943 0.944976973 -0.081648921 0.785321644 1 4.7572086 4.42022727 112849 trans-L-3-hydroxyproline dehydratase "GO:0016836,GO:0018112,GO:0050346" hydro-lyase activity|proline racemase activity|trans-L-3-hydroxyproline dehydratase activity hsa00330 Arginine and proline metabolism L3MBTL1 291.0202059 322.5283036 259.5121081 0.804618092 -0.313623918 0.324953985 1 2.654239442 2.099911879 26013 L3MBTL histone methyl-lysine binding protein 1 "GO:0000785,GO:0000793,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005886,GO:0006325,GO:0007088,GO:0008270,GO:0030097,GO:0031491,GO:0031493,GO:0032093,GO:0035064,GO:0042393,GO:0042802,GO:0045652,GO:0045892,GO:0051726,GO:1901796" "chromatin|condensed chromosome|chromatin binding|protein binding|nucleus|nucleoplasm|nucleolus|plasma membrane|chromatin organization|regulation of mitotic nuclear division|zinc ion binding|hemopoiesis|nucleosome binding|nucleosomal histone binding|SAM domain binding|methylated histone binding|histone binding|identical protein binding|regulation of megakaryocyte differentiation|negative regulation of transcription, DNA-templated|regulation of cell cycle|regulation of signal transduction by p53 class mediator" L3MBTL2 439.1709725 490.0349387 388.3070062 0.792406777 -0.335686877 0.234413146 1 7.622344516 5.93892627 83746 L3MBTL histone methyl-lysine binding protein 2 "GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0008270,GO:0035064,GO:0042393,GO:0045892,GO:0070317" "chromatin binding|protein binding|nucleus|nucleoplasm|chromatin organization|zinc ion binding|methylated histone binding|histone binding|negative regulation of transcription, DNA-templated|negative regulation of G0 to G1 transition" other L3MBTL3 472.0584806 470.267075 473.8498863 1.007618674 0.010949764 0.977083246 1 4.531832697 4.489947413 84456 L3MBTL histone methyl-lysine binding protein 3 "GO:0003674,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006325,GO:0008270,GO:0030225,GO:0030851,GO:0042393,GO:0042802,GO:0043249,GO:0045892" "molecular_function|chromatin binding|protein binding|nucleus|nucleoplasm|nucleolus|chromatin organization|zinc ion binding|macrophage differentiation|granulocyte differentiation|histone binding|identical protein binding|erythrocyte maturation|negative regulation of transcription, DNA-templated" LACC1 269.7659488 294.4371288 245.0947688 0.83241801 -0.264619916 0.420840195 1 2.989643914 2.446989527 144811 laccase domain containing 1 "GO:0002221,GO:0002367,GO:0004000,GO:0004731,GO:0005507,GO:0005515,GO:0005634,GO:0005777,GO:0005783,GO:0006954,GO:0016682,GO:0017061,GO:0030641,GO:0045087,GO:0047975,GO:0050727,GO:0055114,GO:0070431,GO:1900542" "pattern recognition receptor signaling pathway|cytokine production involved in immune response|adenosine deaminase activity|purine-nucleoside phosphorylase activity|copper ion binding|protein binding|nucleus|peroxisome|endoplasmic reticulum|inflammatory response|oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor|S-methyl-5-thioadenosine phosphorylase activity|regulation of cellular pH|innate immune response|guanosine phosphorylase activity|regulation of inflammatory response|oxidation-reduction process|nucleotide-binding oligomerization domain containing 2 signaling pathway|regulation of purine nucleotide metabolic process" LACTB 796.2442118 679.3902654 913.0981582 1.343996529 0.426529412 0.090278762 1 9.725807349 12.85271828 114294 lactamase beta "GO:0005739,GO:0005829,GO:0006508,GO:0006629,GO:0008233,GO:0019216,GO:0042802" mitochondrion|cytosol|proteolysis|lipid metabolic process|peptidase activity|regulation of lipid metabolic process|identical protein binding LACTB2 503.9647112 500.4390776 507.4903448 1.014090161 0.020185926 0.948924644 1 17.50164731 17.45125544 51110 lactamase beta 2 "GO:0003727,GO:0004521,GO:0005515,GO:0005759,GO:0008270,GO:0090502" "single-stranded RNA binding|endoribonuclease activity|protein binding|mitochondrial matrix|zinc ion binding|RNA phosphodiester bond hydrolysis, endonucleolytic" LAG3 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.082749593 0.025055525 3902 lymphocyte activating 3 "GO:0002250,GO:0002270,GO:0003823,GO:0004888,GO:0005515,GO:0005576,GO:0005886,GO:0007166,GO:0009897,GO:0016021,GO:0019886,GO:0032703,GO:0042289,GO:0045590,GO:0045954,GO:0050776" adaptive immune response|plasmacytoid dendritic cell activation|antigen binding|transmembrane signaling receptor activity|protein binding|extracellular region|plasma membrane|cell surface receptor signaling pathway|external side of plasma membrane|integral component of membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|negative regulation of interleukin-2 production|MHC class II protein binding|negative regulation of regulatory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity|regulation of immune response LAGE3 196.31236 208.0827765 184.5419436 0.886867941 -0.173208799 0.644598823 1 11.70178645 10.2042785 8270 L antigen family member 3 "GO:0000408,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008033,GO:0008150,GO:0016604,GO:0045944,GO:0070525" EKC/KEOPS complex|protein binding|nucleus|nucleoplasm|cytoplasm|tRNA processing|biological_process|nuclear body|positive regulation of transcription by RNA polymerase II|tRNA threonylcarbamoyladenosine metabolic process LAMA1 196.6941728 155.0216685 238.3666771 1.537634573 0.62071268 0.089883404 1 0.858039985 1.297274377 284217 laminin subunit alpha 1 "GO:0002011,GO:0005102,GO:0005201,GO:0005515,GO:0005576,GO:0005604,GO:0005606,GO:0005608,GO:0005615,GO:0005911,GO:0006468,GO:0007155,GO:0007166,GO:0007411,GO:0008022,GO:0009887,GO:0009888,GO:0016020,GO:0030155,GO:0030198,GO:0030334,GO:0031012,GO:0043010,GO:0043208,GO:0045198,GO:0045995,GO:0048514,GO:0060441,GO:0060445,GO:0061304,GO:0062023" morphogenesis of an epithelial sheet|signaling receptor binding|extracellular matrix structural constituent|protein binding|extracellular region|basement membrane|laminin-1 complex|laminin-3 complex|extracellular space|cell-cell junction|protein phosphorylation|cell adhesion|cell surface receptor signaling pathway|axon guidance|protein C-terminus binding|animal organ morphogenesis|tissue development|membrane|regulation of cell adhesion|extracellular matrix organization|regulation of cell migration|extracellular matrix|camera-type eye development|glycosphingolipid binding|establishment of epithelial cell apical/basal polarity|regulation of embryonic development|blood vessel morphogenesis|epithelial tube branching involved in lung morphogenesis|branching involved in salivary gland morphogenesis|retinal blood vessel morphogenesis|collagen-containing extracellular matrix "hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222,hsa05410,hsa05412,hsa05414,hsa05416" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Viral myocarditis LAMA2 11.56847002 13.52538047 9.61155956 0.710631363 -0.492826733 0.700204091 1 0.0455295 0.031813279 3908 laminin subunit alpha 2 "GO:0005102,GO:0005198,GO:0005201,GO:0005576,GO:0005604,GO:0007155,GO:0007411,GO:0007517,GO:0009887,GO:0009888,GO:0014037,GO:0030155,GO:0030198,GO:0030334,GO:0031594,GO:0032224,GO:0035633,GO:0042383,GO:0043083,GO:0043197,GO:0045995,GO:0062023" "signaling receptor binding|structural molecule activity|extracellular matrix structural constituent|extracellular region|basement membrane|cell adhesion|axon guidance|muscle organ development|animal organ morphogenesis|tissue development|Schwann cell differentiation|regulation of cell adhesion|extracellular matrix organization|regulation of cell migration|neuromuscular junction|positive regulation of synaptic transmission, cholinergic|maintenance of blood-brain barrier|sarcolemma|synaptic cleft|dendritic spine|regulation of embryonic development|collagen-containing extracellular matrix" "hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222,hsa05410,hsa05412,hsa05414,hsa05416" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Viral myocarditis LAMA3 673.5326667 788.633723 558.4316104 0.70810009 -0.497974795 0.053240523 1 3.716701903 2.587757395 3909 laminin subunit alpha 3 "GO:0001738,GO:0005178,GO:0005198,GO:0005201,GO:0005576,GO:0005604,GO:0005610,GO:0005783,GO:0007229,GO:0007411,GO:0008544,GO:0009887,GO:0009888,GO:0016477,GO:0030155,GO:0030198,GO:0030334,GO:0031581,GO:0035987,GO:0045995,GO:0062023,GO:0070062,GO:0098609" morphogenesis of a polarized epithelium|integrin binding|structural molecule activity|extracellular matrix structural constituent|extracellular region|basement membrane|laminin-5 complex|endoplasmic reticulum|integrin-mediated signaling pathway|axon guidance|epidermis development|animal organ morphogenesis|tissue development|cell migration|regulation of cell adhesion|extracellular matrix organization|regulation of cell migration|hemidesmosome assembly|endodermal cell differentiation|regulation of embryonic development|collagen-containing extracellular matrix|extracellular exosome|cell-cell adhesion "hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMA4 820.2228065 804.2399313 836.2056817 1.039746535 0.056231877 0.827027208 1 5.692414722 5.81962758 3910 laminin subunit alpha 4 "GO:0005102,GO:0005201,GO:0005515,GO:0005576,GO:0005604,GO:0007155,GO:0030155,GO:0030198,GO:0030334,GO:0045995,GO:0062023,GO:0070062,GO:0120163" signaling receptor binding|extracellular matrix structural constituent|protein binding|extracellular region|basement membrane|cell adhesion|regulation of cell adhesion|extracellular matrix organization|regulation of cell migration|regulation of embryonic development|collagen-containing extracellular matrix|extracellular exosome|negative regulation of cold-induced thermogenesis "hsa04151,hsa04510,hsa04512,hsa05143,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|African trypanosomiasis|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMA5 9337.305748 10148.19701 8526.414486 0.840190083 -0.251212338 0.314620425 1 46.79777265 38.66107385 3911 laminin subunit alpha 5 "GO:0001658,GO:0001738,GO:0001755,GO:0001942,GO:0005178,GO:0005201,GO:0005576,GO:0005604,GO:0005610,GO:0005615,GO:0005634,GO:0007229,GO:0007411,GO:0007517,GO:0009887,GO:0009888,GO:0016331,GO:0016477,GO:0019221,GO:0030155,GO:0030198,GO:0030324,GO:0030334,GO:0031594,GO:0034446,GO:0042127,GO:0042475,GO:0043083,GO:0043259,GO:0043260,GO:0045995,GO:0060271,GO:0060445,GO:0062023,GO:0070062,GO:0072659,GO:0098609" branching involved in ureteric bud morphogenesis|morphogenesis of a polarized epithelium|neural crest cell migration|hair follicle development|integrin binding|extracellular matrix structural constituent|extracellular region|basement membrane|laminin-5 complex|extracellular space|nucleus|integrin-mediated signaling pathway|axon guidance|muscle organ development|animal organ morphogenesis|tissue development|morphogenesis of embryonic epithelium|cell migration|cytokine-mediated signaling pathway|regulation of cell adhesion|extracellular matrix organization|lung development|regulation of cell migration|neuromuscular junction|substrate adhesion-dependent cell spreading|regulation of cell population proliferation|odontogenesis of dentin-containing tooth|synaptic cleft|laminin-10 complex|laminin-11 complex|regulation of embryonic development|cilium assembly|branching involved in salivary gland morphogenesis|collagen-containing extracellular matrix|extracellular exosome|protein localization to plasma membrane|cell-cell adhesion "hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMB1 8320.053344 8132.915321 8507.191366 1.046019912 0.064910315 0.793385163 1 66.75465134 68.65823934 3912 laminin subunit beta 1 "GO:0005178,GO:0005198,GO:0005201,GO:0005515,GO:0005576,GO:0005604,GO:0005606,GO:0005607,GO:0005615,GO:0005788,GO:0007155,GO:0009887,GO:0009888,GO:0016477,GO:0021812,GO:0030198,GO:0030335,GO:0031175,GO:0034446,GO:0035987,GO:0042476,GO:0043256,GO:0043257,GO:0043259,GO:0043687,GO:0044267,GO:0048471,GO:0050679,GO:0062023,GO:0070062,GO:0070831" integrin binding|structural molecule activity|extracellular matrix structural constituent|protein binding|extracellular region|basement membrane|laminin-1 complex|laminin-2 complex|extracellular space|endoplasmic reticulum lumen|cell adhesion|animal organ morphogenesis|tissue development|cell migration|neuronal-glial interaction involved in cerebral cortex radial glia guided migration|extracellular matrix organization|positive regulation of cell migration|neuron projection development|substrate adhesion-dependent cell spreading|endodermal cell differentiation|odontogenesis|laminin complex|laminin-8 complex|laminin-10 complex|post-translational protein modification|cellular protein metabolic process|perinuclear region of cytoplasm|positive regulation of epithelial cell proliferation|collagen-containing extracellular matrix|extracellular exosome|basement membrane assembly "hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMB2 3168.35292 3025.523571 3311.182268 1.094416286 0.130161604 0.583252463 1 28.28777721 30.44055375 3913 laminin subunit beta 2 "GO:0005178,GO:0005198,GO:0005201,GO:0005515,GO:0005576,GO:0005604,GO:0005608,GO:0005788,GO:0007411,GO:0007528,GO:0007601,GO:0009887,GO:0009888,GO:0014002,GO:0014044,GO:0016477,GO:0030198,GO:0031594,GO:0034446,GO:0043083,GO:0043256,GO:0043260,GO:0043687,GO:0044267,GO:0048677,GO:0060041,GO:0062023,GO:0070062,GO:0070831,GO:0072249,GO:0072274" integrin binding|structural molecule activity|extracellular matrix structural constituent|protein binding|extracellular region|basement membrane|laminin-3 complex|endoplasmic reticulum lumen|axon guidance|neuromuscular junction development|visual perception|animal organ morphogenesis|tissue development|astrocyte development|Schwann cell development|cell migration|extracellular matrix organization|neuromuscular junction|substrate adhesion-dependent cell spreading|synaptic cleft|laminin complex|laminin-11 complex|post-translational protein modification|cellular protein metabolic process|axon extension involved in regeneration|retina development in camera-type eye|collagen-containing extracellular matrix|extracellular exosome|basement membrane assembly|metanephric glomerular visceral epithelial cell development|metanephric glomerular basement membrane development "hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMB3 15126.52752 15666.55224 14586.50279 0.931060169 -0.10305369 0.6950653 1 186.212717 170.474044 3914 laminin subunit beta 3 "GO:0005198,GO:0005201,GO:0005515,GO:0005576,GO:0008544,GO:0009887,GO:0009888,GO:0016477,GO:0030198,GO:0031581,GO:0034446,GO:0035987,GO:0043256,GO:0044877,GO:0062023,GO:0070831" structural molecule activity|extracellular matrix structural constituent|protein binding|extracellular region|epidermis development|animal organ morphogenesis|tissue development|cell migration|extracellular matrix organization|hemidesmosome assembly|substrate adhesion-dependent cell spreading|endodermal cell differentiation|laminin complex|protein-containing complex binding|collagen-containing extracellular matrix|basement membrane assembly "hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMC1 9695.837771 10792.2132 8599.462338 0.79682102 -0.327672388 0.191245128 1 72.63975072 56.91232215 3915 laminin subunit gamma 1 "GO:0005201,GO:0005576,GO:0005604,GO:0005606,GO:0005615,GO:0005788,GO:0007155,GO:0007492,GO:0009887,GO:0009888,GO:0016477,GO:0022617,GO:0030023,GO:0030198,GO:0031581,GO:0034446,GO:0035633,GO:0043259,GO:0043260,GO:0043687,GO:0044267,GO:0050679,GO:0062023,GO:0065003,GO:0070062" extracellular matrix structural constituent|extracellular region|basement membrane|laminin-1 complex|extracellular space|endoplasmic reticulum lumen|cell adhesion|endoderm development|animal organ morphogenesis|tissue development|cell migration|extracellular matrix disassembly|extracellular matrix constituent conferring elasticity|extracellular matrix organization|hemidesmosome assembly|substrate adhesion-dependent cell spreading|maintenance of blood-brain barrier|laminin-10 complex|laminin-11 complex|post-translational protein modification|cellular protein metabolic process|positive regulation of epithelial cell proliferation|collagen-containing extracellular matrix|protein-containing complex assembly|extracellular exosome "hsa04151,hsa04510,hsa04512,hsa05020,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Prion disease|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMC2 20781.58105 20009.23979 21553.92231 1.077198461 0.107284074 0.696262244 1 171.1582549 181.2862029 3918 laminin subunit gamma 2 "GO:0005102,GO:0005201,GO:0005576,GO:0005604,GO:0005607,GO:0005615,GO:0005938,GO:0007155,GO:0008045,GO:0008201,GO:0008284,GO:0008544,GO:0009887,GO:0009888,GO:0016020,GO:0016358,GO:0030198,GO:0030335,GO:0031581,GO:0048471,GO:0062023" signaling receptor binding|extracellular matrix structural constituent|extracellular region|basement membrane|laminin-2 complex|extracellular space|cell cortex|cell adhesion|motor neuron axon guidance|heparin binding|positive regulation of cell population proliferation|epidermis development|animal organ morphogenesis|tissue development|membrane|dendrite development|extracellular matrix organization|positive regulation of cell migration|hemidesmosome assembly|perinuclear region of cytoplasm|collagen-containing extracellular matrix "hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMP1 5328.793467 5504.829853 5152.75708 0.936042933 -0.095353393 0.692408746 1 127.8427554 117.6638541 3916 lysosomal associated membrane protein 1 "GO:0000421,GO:0001618,GO:0005515,GO:0005737,GO:0005764,GO:0005765,GO:0005770,GO:0005771,GO:0005829,GO:0005886,GO:0005887,GO:0009897,GO:0010008,GO:0016020,GO:0019899,GO:0019904,GO:0030285,GO:0030425,GO:0031902,GO:0035577,GO:0042383,GO:0042470,GO:0043025,GO:0043312,GO:0043323,GO:0044194,GO:0044754,GO:0045954,GO:0046718,GO:0048102,GO:0048471,GO:0050821,GO:0061474,GO:0070062,GO:0072594,GO:0090160,GO:0097208,GO:0101003,GO:0140507,GO:1902513" autophagosome membrane|virus receptor activity|protein binding|cytoplasm|lysosome|lysosomal membrane|late endosome|multivesicular body|cytosol|plasma membrane|integral component of plasma membrane|external side of plasma membrane|endosome membrane|membrane|enzyme binding|protein domain specific binding|integral component of synaptic vesicle membrane|dendrite|late endosome membrane|azurophil granule membrane|sarcolemma|melanosome|neuronal cell body|neutrophil degranulation|positive regulation of natural killer cell degranulation|cytolytic granule|autolysosome|positive regulation of natural killer cell mediated cytotoxicity|viral entry into host cell|autophagic cell death|perinuclear region of cytoplasm|protein stabilization|phagolysosome membrane|extracellular exosome|establishment of protein localization to organelle|Golgi to lysosome transport|alveolar lamellar body|ficolin-1-rich granule membrane|granzyme-mediated programmed cell death signaling pathway|regulation of organelle transport along microtubule "hsa04140,hsa04142,hsa04145,hsa05152" Autophagy - animal|Lysosome|Phagosome|Tuberculosis LAMP2 6136.50554 6447.444831 5825.566249 0.903546506 -0.146329236 0.546328843 1 36.65192594 32.56255617 3920 lysosomal associated membrane protein 2 "GO:0002576,GO:0005515,GO:0005615,GO:0005764,GO:0005765,GO:0005770,GO:0005886,GO:0006605,GO:0009267,GO:0016020,GO:0017038,GO:0019899,GO:0019904,GO:0030670,GO:0031088,GO:0031647,GO:0031902,GO:0035577,GO:0043202,GO:0043312,GO:0044754,GO:0045121,GO:0046716,GO:0050821,GO:0061684,GO:0061740,GO:0070062,GO:0072594,GO:0097352,GO:0097637,GO:0098857,GO:0101003,GO:1905146,GO:1990836" platelet degranulation|protein binding|extracellular space|lysosome|lysosomal membrane|late endosome|plasma membrane|protein targeting|cellular response to starvation|membrane|protein import|enzyme binding|protein domain specific binding|phagocytic vesicle membrane|platelet dense granule membrane|regulation of protein stability|late endosome membrane|azurophil granule membrane|lysosomal lumen|neutrophil degranulation|autolysosome|membrane raft|muscle cell cellular homeostasis|protein stabilization|chaperone-mediated autophagy|protein targeting to lysosome involved in chaperone-mediated autophagy|extracellular exosome|establishment of protein localization to organelle|autophagosome maturation|integral component of autophagosome membrane|membrane microdomain|ficolin-1-rich granule membrane|lysosomal protein catabolic process|lysosomal matrix "hsa04140,hsa04142,hsa04145,hsa05152" Autophagy - animal|Lysosome|Phagosome|Tuberculosis LAMP3 171.9513382 237.2143652 106.6883111 0.449754849 -1.152789258 0.002941954 0.35290545 2.119486806 0.93729813 27074 lysosomal associated membrane protein 3 "GO:0002250,GO:0005765,GO:0005769,GO:0005886,GO:0010506,GO:0010628,GO:0016021,GO:0031902,GO:0031982,GO:0035455,GO:0043154,GO:0043231,GO:0046718,GO:0048471,GO:0072594,GO:0097233,GO:1901799,GO:1903900" adaptive immune response|lysosomal membrane|early endosome|plasma membrane|regulation of autophagy|positive regulation of gene expression|integral component of membrane|late endosome membrane|vesicle|response to interferon-alpha|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|intracellular membrane-bounded organelle|viral entry into host cell|perinuclear region of cytoplasm|establishment of protein localization to organelle|alveolar lamellar body membrane|negative regulation of proteasomal protein catabolic process|regulation of viral life cycle hsa04142 Lysosome LAMTOR1 1241.196597 1232.890451 1249.502743 1.013474264 0.019309454 0.939828321 1 60.4197405 60.20918647 55004 "late endosomal/lysosomal adaptor, MAPK and MTOR activator 1" "GO:0001558,GO:0001919,GO:0005085,GO:0005515,GO:0005764,GO:0005765,GO:0005886,GO:0007032,GO:0007040,GO:0007050,GO:0010872,GO:0010874,GO:0016197,GO:0016241,GO:0031902,GO:0032008,GO:0032418,GO:0034613,GO:0035577,GO:0035579,GO:0042632,GO:0043312,GO:0043410,GO:0045121,GO:0050790,GO:0051020,GO:0060090,GO:0060620,GO:0070062,GO:0071230,GO:0071986,GO:0101003" regulation of cell growth|regulation of receptor recycling|guanyl-nucleotide exchange factor activity|protein binding|lysosome|lysosomal membrane|plasma membrane|endosome organization|lysosome organization|cell cycle arrest|regulation of cholesterol esterification|regulation of cholesterol efflux|endosomal transport|regulation of macroautophagy|late endosome membrane|positive regulation of TOR signaling|lysosome localization|cellular protein localization|azurophil granule membrane|specific granule membrane|cholesterol homeostasis|neutrophil degranulation|positive regulation of MAPK cascade|membrane raft|regulation of catalytic activity|GTPase binding|molecular adaptor activity|regulation of cholesterol import|extracellular exosome|cellular response to amino acid stimulus|Ragulator complex|ficolin-1-rich granule membrane hsa04150 mTOR signaling pathway LAMTOR2 751.8027105 749.0979955 754.5074255 1.007221258 0.010380638 0.973224051 1 64.3767846 63.75662851 28956 "late endosomal/lysosomal adaptor, MAPK and MTOR activator 2" "GO:0000165,GO:0000186,GO:0001558,GO:0005085,GO:0005515,GO:0005765,GO:0005770,GO:0005886,GO:0007050,GO:0010008,GO:0010761,GO:0016241,GO:0032008,GO:0034613,GO:0035579,GO:0043312,GO:0060090,GO:0070821,GO:0071230,GO:0071986,GO:0150116,GO:1902414" MAPK cascade|activation of MAPKK activity|regulation of cell growth|guanyl-nucleotide exchange factor activity|protein binding|lysosomal membrane|late endosome|plasma membrane|cell cycle arrest|endosome membrane|fibroblast migration|regulation of macroautophagy|positive regulation of TOR signaling|cellular protein localization|specific granule membrane|neutrophil degranulation|molecular adaptor activity|tertiary granule membrane|cellular response to amino acid stimulus|Ragulator complex|regulation of cell-substrate junction organization|protein localization to cell junction hsa04150 mTOR signaling pathway LAMTOR3 420.5624095 455.7012806 385.4235384 0.845781118 -0.241643743 0.398994657 1 5.707566253 4.746572569 8649 "late endosomal/lysosomal adaptor, MAPK and MTOR activator 3" "GO:0000165,GO:0000186,GO:0005085,GO:0005515,GO:0005765,GO:0005886,GO:0005925,GO:0007050,GO:0010008,GO:0016241,GO:0019209,GO:0032008,GO:0034613,GO:0035579,GO:0043312,GO:0060090,GO:0070062,GO:0070821,GO:0071230,GO:0071986,GO:1902414" MAPK cascade|activation of MAPKK activity|guanyl-nucleotide exchange factor activity|protein binding|lysosomal membrane|plasma membrane|focal adhesion|cell cycle arrest|endosome membrane|regulation of macroautophagy|kinase activator activity|positive regulation of TOR signaling|cellular protein localization|specific granule membrane|neutrophil degranulation|molecular adaptor activity|extracellular exosome|tertiary granule membrane|cellular response to amino acid stimulus|Ragulator complex|protein localization to cell junction "hsa04010,hsa04150" MAPK signaling pathway|mTOR signaling pathway LAMTOR4 552.6270042 491.0753526 614.1786559 1.250681087 0.322713962 0.227805112 1 27.79192896 34.17719781 389541 "late endosomal/lysosomal adaptor, MAPK and MTOR activator 4" "GO:0005085,GO:0005515,GO:0005764,GO:0005765,GO:0007050,GO:0008361,GO:0016241,GO:0032008,GO:0043231,GO:0050790,GO:0060090,GO:0061462,GO:0071230,GO:0071986" guanyl-nucleotide exchange factor activity|protein binding|lysosome|lysosomal membrane|cell cycle arrest|regulation of cell size|regulation of macroautophagy|positive regulation of TOR signaling|intracellular membrane-bounded organelle|regulation of catalytic activity|molecular adaptor activity|protein localization to lysosome|cellular response to amino acid stimulus|Ragulator complex hsa04150 mTOR signaling pathway LAMTOR5 1225.100979 1024.807674 1425.394283 1.390889548 0.476007858 0.049055515 1 88.21306785 120.6415055 10542 "late endosomal/lysosomal adaptor, MAPK and MTOR activator 5" "GO:0005085,GO:0005515,GO:0005764,GO:0005765,GO:0005829,GO:0007050,GO:0008361,GO:0009615,GO:0010628,GO:0016241,GO:0019079,GO:0032008,GO:0032757,GO:0032991,GO:0043123,GO:0043154,GO:0051092,GO:0060090,GO:0061462,GO:0071230,GO:0071986,GO:1900182,GO:1904263,GO:1905636" guanyl-nucleotide exchange factor activity|protein binding|lysosome|lysosomal membrane|cytosol|cell cycle arrest|regulation of cell size|response to virus|positive regulation of gene expression|regulation of macroautophagy|viral genome replication|positive regulation of TOR signaling|positive regulation of interleukin-8 production|protein-containing complex|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of NF-kappaB transcription factor activity|molecular adaptor activity|protein localization to lysosome|cellular response to amino acid stimulus|Ragulator complex|positive regulation of protein localization to nucleus|positive regulation of TORC1 signaling|positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding hsa04150 mTOR signaling pathway LANCL1 3390.929106 3153.494478 3628.363734 1.150585092 0.202367682 0.393740467 1 35.34891922 39.99134965 10314 LanC like 1 "GO:0004364,GO:0004930,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0005975,GO:0007186,GO:0008270,GO:0017124,GO:0043295,GO:0043523,GO:0050750,GO:1903203" glutathione transferase activity|G protein-coupled receptor activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|carbohydrate metabolic process|G protein-coupled receptor signaling pathway|zinc ion binding|SH3 domain binding|glutathione binding|regulation of neuron apoptotic process|low-density lipoprotein particle receptor binding|regulation of oxidative stress-induced neuron death LANCL2 196.0796167 189.3553266 202.8039067 1.071022983 0.098989439 0.799030066 1 2.26632558 2.386669425 55915 LanC like 2 "GO:0005515,GO:0005524,GO:0005525,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0005975,GO:0009789,GO:0010314,GO:0030864,GO:0032266,GO:0045892,GO:0070273" "protein binding|ATP binding|GTP binding|nucleus|nucleoplasm|cytosol|plasma membrane|carbohydrate metabolic process|positive regulation of abscisic acid-activated signaling pathway|phosphatidylinositol-5-phosphate binding|cortical actin cytoskeleton|phosphatidylinositol-3-phosphate binding|negative regulation of transcription, DNA-templated|phosphatidylinositol-4-phosphate binding" LANCL3 5.405244648 3.121241648 7.689247648 2.463522058 1.300722389 0.455625732 1 0.015765184 0.038187978 347404 LanC like 3 "GO:0005886,GO:0005975" plasma membrane|carbohydrate metabolic process LAP3 1412.257205 1295.315284 1529.199126 1.180561324 0.239472983 0.317507985 1 31.29406791 36.32634895 51056 leucine aminopeptidase 3 "GO:0004177,GO:0005515,GO:0005634,GO:0005654,GO:0005802,GO:0005829,GO:0005925,GO:0006508,GO:0008235,GO:0030145,GO:0030496,GO:0070006,GO:0070062" aminopeptidase activity|protein binding|nucleus|nucleoplasm|trans-Golgi network|cytosol|focal adhesion|proteolysis|metalloexopeptidase activity|manganese ion binding|midbody|metalloaminopeptidase activity|extracellular exosome "hsa00330,hsa00480" Arginine and proline metabolism|Glutathione metabolism LAPTM4A 4271.923004 3912.996613 4630.849396 1.183453464 0.243002977 0.308600913 1 152.9885989 178.0251789 9741 lysosomal protein transmembrane 4 alpha "GO:0005515,GO:0005765,GO:0005794,GO:0016021,GO:0031902" protein binding|lysosomal membrane|Golgi apparatus|integral component of membrane|late endosome membrane hsa04142 Lysosome LAPTM4B 5194.531 5159.412444 5229.649557 1.013613394 0.019507493 0.936160606 1 112.755266 112.3777553 55353 lysosomal protein transmembrane 4 beta "GO:0005515,GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005886,GO:0007032,GO:0016021,GO:0019900,GO:0031625,GO:0031902,GO:0032509,GO:0032585,GO:0032911,GO:0042995,GO:0097001,GO:0097213,GO:0097487,GO:1902936,GO:1905166,GO:1905671" "protein binding|lysosome|lysosomal membrane|endosome|early endosome|plasma membrane|endosome organization|integral component of membrane|kinase binding|ubiquitin protein ligase binding|late endosome membrane|endosome transport via multivesicular body sorting pathway|multivesicular body membrane|negative regulation of transforming growth factor beta1 production|cell projection|ceramide binding|regulation of lysosomal membrane permeability|multivesicular body, internal vesicle|phosphatidylinositol bisphosphate binding|negative regulation of lysosomal protein catabolic process|regulation of lysosome organization" hsa04142 Lysosome LAPTM5 24.09809599 27.05076095 21.14543103 0.781694499 -0.355323209 0.687544819 1 0.663137067 0.509696367 7805 lysosomal protein transmembrane 5 "GO:0002357,GO:0002720,GO:0005515,GO:0005764,GO:0005765,GO:0005829,GO:0005887,GO:0006622,GO:0006886,GO:0006919,GO:0012502,GO:0030133,GO:0031398,GO:0031410,GO:0031625,GO:0032689,GO:0032703,GO:0032735,GO:0032991,GO:0043410,GO:0048471,GO:0050860,GO:0050868,GO:0050869,GO:0060907,GO:0090160,GO:0097214,GO:0140036,GO:0140311,GO:1901224,GO:1903265,GO:1904093,GO:2000060,GO:2000646" defense response to tumor cell|positive regulation of cytokine production involved in immune response|protein binding|lysosome|lysosomal membrane|cytosol|integral component of plasma membrane|protein targeting to lysosome|intracellular protein transport|activation of cysteine-type endopeptidase activity involved in apoptotic process|induction of programmed cell death|transport vesicle|positive regulation of protein ubiquitination|cytoplasmic vesicle|ubiquitin protein ligase binding|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|positive regulation of interleukin-12 production|protein-containing complex|positive regulation of MAPK cascade|perinuclear region of cytoplasm|negative regulation of T cell receptor signaling pathway|negative regulation of T cell activation|negative regulation of B cell activation|positive regulation of macrophage cytokine production|Golgi to lysosome transport|positive regulation of lysosomal membrane permeability|ubiquitin-dependent protein binding|protein sequestering activity|positive regulation of NIK/NF-kappaB signaling|positive regulation of tumor necrosis factor-mediated signaling pathway|negative regulation of autophagic cell death|positive regulation of ubiquitin-dependent protein catabolic process|positive regulation of receptor catabolic process hsa04142 Lysosome LARGE1 22.78027936 17.687036 27.87352272 1.575929552 0.656203044 0.433950845 1 0.114651355 0.177658982 9215 LARGE xylosyl- and glucuronyltransferase 1 "GO:0000139,GO:0005794,GO:0006044,GO:0006486,GO:0006493,GO:0006688,GO:0008375,GO:0009101,GO:0015020,GO:0016757,GO:0030145,GO:0030173,GO:0035252,GO:0035269,GO:0042285,GO:0043403,GO:0046716,GO:0060538" "Golgi membrane|Golgi apparatus|N-acetylglucosamine metabolic process|protein glycosylation|protein O-linked glycosylation|glycosphingolipid biosynthetic process|acetylglucosaminyltransferase activity|glycoprotein biosynthetic process|glucuronosyltransferase activity|transferase activity, transferring glycosyl groups|manganese ion binding|integral component of Golgi membrane|UDP-xylosyltransferase activity|protein O-linked mannosylation|xylosyltransferase activity|skeletal muscle tissue regeneration|muscle cell cellular homeostasis|skeletal muscle organ development" hsa00515 Mannose type O-glycan biosynthesis LARGE2 16.65165254 20.80827765 12.49502743 0.600483502 -0.735803487 0.441803933 1 0.371902054 0.219584073 120071 LARGE xylosyl- and glucuronyltransferase 2 "GO:0000139,GO:0005515,GO:0005794,GO:0006493,GO:0015020,GO:0016021,GO:0030145,GO:0035252,GO:0035269,GO:0042285,GO:0046716" Golgi membrane|protein binding|Golgi apparatus|protein O-linked glycosylation|glucuronosyltransferase activity|integral component of membrane|manganese ion binding|UDP-xylosyltransferase activity|protein O-linked mannosylation|xylosyltransferase activity|muscle cell cellular homeostasis hsa00515 Mannose type O-glycan biosynthesis LARP1 6797.170813 7365.089875 6229.251751 0.84578082 -0.241644251 0.321960591 1 48.55606055 40.38057093 23367 "La ribonucleoprotein 1, translational regulator" "GO:0000339,GO:0000340,GO:0003723,GO:0003730,GO:0005515,GO:0005737,GO:0005844,GO:0006413,GO:0008190,GO:0008283,GO:0008494,GO:0010494,GO:0010608,GO:0016020,GO:0016239,GO:0017148,GO:0031369,GO:0031929,GO:0031931,GO:0038202,GO:0042788,GO:0043024,GO:0045070,GO:0045296,GO:0045947,GO:0045948,GO:0048027,GO:0048255,GO:0072752,GO:1990928" RNA cap binding|RNA 7-methylguanosine cap binding|RNA binding|mRNA 3'-UTR binding|protein binding|cytoplasm|polysome|translational initiation|eukaryotic initiation factor 4E binding|cell population proliferation|translation activator activity|cytoplasmic stress granule|posttranscriptional regulation of gene expression|membrane|positive regulation of macroautophagy|negative regulation of translation|translation initiation factor binding|TOR signaling|TORC1 complex|TORC1 signaling|polysomal ribosome|ribosomal small subunit binding|positive regulation of viral genome replication|cadherin binding|negative regulation of translational initiation|positive regulation of translational initiation|mRNA 5'-UTR binding|mRNA stabilization|cellular response to rapamycin|response to amino acid starvation LARP1B 730.7119997 712.6835096 748.7404897 1.050593257 0.07120423 0.784249307 1 3.989783809 4.121498549 55132 La ribonucleoprotein 1B "GO:0003723,GO:0005515,GO:0005634" RNA binding|protein binding|nucleus LARP4 1779.811998 1810.320156 1749.30384 0.96629529 -0.049463966 0.83687061 1 13.7901027 13.10233025 113251 La ribonucleoprotein 4 "GO:0003723,GO:0003730,GO:0005515,GO:0005829,GO:0005844,GO:0006412,GO:0007010,GO:0008143,GO:0010494,GO:0010608,GO:0016020,GO:0022604,GO:0022627,GO:0045727" RNA binding|mRNA 3'-UTR binding|protein binding|cytosol|polysome|translation|cytoskeleton organization|poly(A) binding|cytoplasmic stress granule|posttranscriptional regulation of gene expression|membrane|regulation of cell morphogenesis|cytosolic small ribosomal subunit|positive regulation of translation LARP4B 1450.544313 1392.073775 1509.014851 1.084004941 0.116371333 0.62796688 1 5.59683734 5.965476315 23185 La ribonucleoprotein 4B "GO:0003723,GO:0003730,GO:0005515,GO:0005730,GO:0005829,GO:0010494,GO:0016020,GO:0042788,GO:0045727,GO:1905870" RNA binding|mRNA 3'-UTR binding|protein binding|nucleolus|cytosol|cytoplasmic stress granule|membrane|polysomal ribosome|positive regulation of translation|positive regulation of 3'-UTR-mediated mRNA stabilization LARP6 1264.432916 1212.082173 1316.78366 1.086381508 0.119530828 0.62191577 1 12.40632871 13.25246991 55323 "La ribonucleoprotein 6, translational regulator" "GO:0005515,GO:0005634,GO:0005737,GO:0005844,GO:0006396,GO:0017022,GO:0032967,GO:0035613,GO:0045727,GO:0048027,GO:1902416,GO:1990825,GO:1990904" protein binding|nucleus|cytoplasm|polysome|RNA processing|myosin binding|positive regulation of collagen biosynthetic process|RNA stem-loop binding|positive regulation of translation|mRNA 5'-UTR binding|positive regulation of mRNA binding|sequence-specific mRNA binding|ribonucleoprotein complex LARP7 601.4126003 573.2680493 629.5571512 1.098189847 0.135127478 0.610775265 1 9.436848295 10.19003266 51574 "La ribonucleoprotein 7, transcriptional regulator" "GO:0000122,GO:0000494,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006397,GO:0007283,GO:0008380,GO:0017070,GO:0030154,GO:0032897,GO:0034244,GO:0048024,GO:0097322,GO:0120259,GO:1904871,GO:1905382,GO:1990438,GO:1990904" "negative regulation of transcription by RNA polymerase II|box C/D RNA 3'-end processing|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|mRNA processing|spermatogenesis|RNA splicing|U6 snRNA binding|cell differentiation|negative regulation of viral transcription|negative regulation of transcription elongation from RNA polymerase II promoter|regulation of mRNA splicing, via spliceosome|7SK snRNA binding|7SK snRNP|positive regulation of protein localization to Cajal body|positive regulation of snRNA transcription by RNA polymerase II|U6 2'-O-snRNA methylation|ribonucleoprotein complex" other LARS1 4192.423964 4816.075863 3568.772065 0.741012427 -0.432430357 0.070014851 1 53.09339335 38.68451472 51520 leucyl-tRNA synthetase 1 "GO:0002161,GO:0004819,GO:0004823,GO:0005096,GO:0005515,GO:0005524,GO:0005737,GO:0005764,GO:0005783,GO:0005829,GO:0006418,GO:0006425,GO:0006429,GO:0008361,GO:0012505,GO:0016604,GO:0017101,GO:0032008,GO:0034198,GO:0043547,GO:0071230,GO:0071233,GO:0106074,GO:1904263,GO:1990253" aminoacyl-tRNA editing activity|glutamine-tRNA ligase activity|leucine-tRNA ligase activity|GTPase activator activity|protein binding|ATP binding|cytoplasm|lysosome|endoplasmic reticulum|cytosol|tRNA aminoacylation for protein translation|glutaminyl-tRNA aminoacylation|leucyl-tRNA aminoacylation|regulation of cell size|endomembrane system|nuclear body|aminoacyl-tRNA synthetase multienzyme complex|positive regulation of TOR signaling|cellular response to amino acid starvation|positive regulation of GTPase activity|cellular response to amino acid stimulus|cellular response to leucine|aminoacyl-tRNA metabolism involved in translational fidelity|positive regulation of TORC1 signaling|cellular response to leucine starvation hsa00970 Aminoacyl-tRNA biosynthesis LARS2 611.2418119 629.450399 593.0332248 0.94214449 -0.085979763 0.74766022 1 5.898614735 5.464352686 23395 "leucyl-tRNA synthetase 2, mitochondrial" "GO:0002161,GO:0004823,GO:0005524,GO:0005739,GO:0005759,GO:0006418,GO:0006429,GO:0032543,GO:0106074" aminoacyl-tRNA editing activity|leucine-tRNA ligase activity|ATP binding|mitochondrion|mitochondrial matrix|tRNA aminoacylation for protein translation|leucyl-tRNA aminoacylation|mitochondrial translation|aminoacyl-tRNA metabolism involved in translational fidelity hsa00970 Aminoacyl-tRNA biosynthesis LAS1L 1387.445173 1350.45722 1424.433127 1.054778416 0.076939954 0.750438089 1 16.45090614 17.06169748 81887 LAS1 like ribosome biogenesis factor "GO:0000460,GO:0000470,GO:0003723,GO:0004519,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0016020,GO:0030687,GO:0071339,GO:0090305,GO:0090730" "maturation of 5.8S rRNA|maturation of LSU-rRNA|RNA binding|endonuclease activity|protein binding|nucleoplasm|nucleolus|rRNA processing|membrane|preribosome, large subunit precursor|MLL1 complex|nucleic acid phosphodiester bond hydrolysis|Las1 complex" LASP1 8139.821511 8170.37022 8109.272801 0.992522075 -0.010828906 0.965560185 1 111.5185786 108.8324932 3927 LIM and SH3 protein 1 "GO:0005515,GO:0005737,GO:0005925,GO:0006811,GO:0015075,GO:0030864,GO:0034220,GO:0045296,GO:0046872,GO:0051015" protein binding|cytoplasm|focal adhesion|ion transport|ion transmembrane transporter activity|cortical actin cytoskeleton|ion transmembrane transport|cadherin binding|metal ion binding|actin filament binding LAT 20.41701844 18.72744989 22.10658699 1.180437653 0.239321845 0.82900801 1 0.556486404 0.645905214 27040 linker for activation of T cells "GO:0000165,GO:0001772,GO:0002250,GO:0005515,GO:0005794,GO:0005886,GO:0006954,GO:0006955,GO:0007229,GO:0007265,GO:0008180,GO:0016021,GO:0019722,GO:0019901,GO:0030159,GO:0035556,GO:0038095,GO:0042110,GO:0043303,GO:0045121,GO:0045860,GO:0050852,GO:0050863" MAPK cascade|immunological synapse|adaptive immune response|protein binding|Golgi apparatus|plasma membrane|inflammatory response|immune response|integrin-mediated signaling pathway|Ras protein signal transduction|COP9 signalosome|integral component of membrane|calcium-mediated signaling|protein kinase binding|signaling receptor complex adaptor activity|intracellular signal transduction|Fc-epsilon receptor signaling pathway|T cell activation|mast cell degranulation|membrane raft|positive regulation of protein kinase activity|T cell receptor signaling pathway|regulation of T cell activation "hsa04014,hsa04015,hsa04064,hsa04650,hsa04658,hsa04659,hsa04660,hsa04664,hsa04666,hsa05135,hsa05235" Ras signaling pathway|Rap1 signaling pathway|NF-kappa B signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Yersinia infection|PD-L1 expression and PD-1 checkpoint pathway in cancer LAT2 481.6895475 521.2473552 442.1317398 0.848218673 -0.237491852 0.390693654 1 14.86004986 12.39365133 7462 linker for activation of T cells family member 2 "GO:0002250,GO:0005515,GO:0005886,GO:0016021,GO:0019722,GO:0035556,GO:0038095,GO:0042113,GO:0042169,GO:0043303,GO:0045121,GO:0050853,GO:0070062" adaptive immune response|protein binding|plasma membrane|integral component of membrane|calcium-mediated signaling|intracellular signal transduction|Fc-epsilon receptor signaling pathway|B cell activation|SH2 domain binding|mast cell degranulation|membrane raft|B cell receptor signaling pathway|extracellular exosome LATS1 464.6315445 515.0048719 414.258217 0.804377278 -0.314055766 0.259329878 1 3.076434237 2.433204487 9113 large tumor suppressor kinase 1 "GO:0000082,GO:0000086,GO:0000287,GO:0000819,GO:0000922,GO:0001827,GO:0001828,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005815,GO:0005829,GO:0006468,GO:0009755,GO:0017015,GO:0018105,GO:0019901,GO:0030216,GO:0030331,GO:0030496,GO:0030833,GO:0033138,GO:0033146,GO:0034613,GO:0035329,GO:0035556,GO:0043065,GO:0043254,GO:0045736,GO:0046620,GO:0051220,GO:0051301,GO:0060644,GO:0090090,GO:0106310,GO:0106311,GO:1900181,GO:2000058" G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|magnesium ion binding|sister chromatid segregation|spindle pole|inner cell mass cell fate commitment|inner cell mass cellular morphogenesis|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|microtubule organizing center|cytosol|protein phosphorylation|hormone-mediated signaling pathway|regulation of transforming growth factor beta receptor signaling pathway|peptidyl-serine phosphorylation|protein kinase binding|keratinocyte differentiation|estrogen receptor binding|midbody|regulation of actin filament polymerization|positive regulation of peptidyl-serine phosphorylation|regulation of intracellular estrogen receptor signaling pathway|cellular protein localization|hippo signaling|intracellular signal transduction|positive regulation of apoptotic process|regulation of protein-containing complex assembly|negative regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of organ growth|cytoplasmic sequestering of protein|cell division|mammary gland epithelial cell differentiation|negative regulation of canonical Wnt signaling pathway|protein serine kinase activity|protein threonine kinase activity|negative regulation of protein localization to nucleus|regulation of ubiquitin-dependent protein catabolic process "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species LATS2 1175.476915 1135.091546 1215.862284 1.071157907 0.099171173 0.684890528 1 10.8329309 11.40960605 26524 large tumor suppressor kinase 2 "GO:0000082,GO:0000922,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0006468,GO:0009755,GO:0017015,GO:0018105,GO:0034451,GO:0035329,GO:0035556,GO:0043065,GO:0045736,GO:0046620,GO:0046872,GO:0051301,GO:0090090,GO:0106310,GO:0106311,GO:1900181" G1/S transition of mitotic cell cycle|spindle pole|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytosol|protein phosphorylation|hormone-mediated signaling pathway|regulation of transforming growth factor beta receptor signaling pathway|peptidyl-serine phosphorylation|centriolar satellite|hippo signaling|intracellular signal transduction|positive regulation of apoptotic process|negative regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of organ growth|metal ion binding|cell division|negative regulation of canonical Wnt signaling pathway|protein serine kinase activity|protein threonine kinase activity|negative regulation of protein localization to nucleus "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species LAX1 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.046585689 54900 lymphocyte transmembrane adaptor 1 "GO:0000188,GO:0002250,GO:0005515,GO:0005794,GO:0005829,GO:0005886,GO:0006955,GO:0016020,GO:0016021,GO:0019901,GO:0035556,GO:0042113,GO:0042169,GO:0045121,GO:0046649,GO:0050851,GO:0050868" inactivation of MAPK activity|adaptive immune response|protein binding|Golgi apparatus|cytosol|plasma membrane|immune response|membrane|integral component of membrane|protein kinase binding|intracellular signal transduction|B cell activation|SH2 domain binding|membrane raft|lymphocyte activation|antigen receptor-mediated signaling pathway|negative regulation of T cell activation LAYN 990.6292295 899.9580085 1081.30045 1.201501004 0.264837854 0.28214281 1 18.45853377 21.80682894 143903 layilin "GO:0001726,GO:0005540,GO:0005925,GO:0009986,GO:0016021,GO:0030246" ruffle|hyaluronic acid binding|focal adhesion|cell surface|integral component of membrane|carbohydrate binding LBH 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.050142965 0.030365305 81606 LBH regulator of WNT signaling pathway "GO:0005515,GO:0005634,GO:0005737,GO:0007275,GO:0032991,GO:0043408,GO:0045892,GO:0045893" "protein binding|nucleus|cytoplasm|multicellular organism development|protein-containing complex|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated" LBHD1 32.54532436 34.33365813 30.75699059 0.895826203 -0.158709229 0.86266099 1 0.989910444 0.871948523 79081 LBH domain containing 1 "GO:0005634,GO:0045893" "nucleus|positive regulation of transcription, DNA-templated" LBP 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.030424645 0.082909763 3929 lipopolysaccharide binding protein "GO:0001530,GO:0002224,GO:0002232,GO:0002281,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0006953,GO:0006968,GO:0008228,GO:0009986,GO:0015920,GO:0016020,GO:0019221,GO:0031663,GO:0032490,GO:0032496,GO:0032720,GO:0032722,GO:0032755,GO:0032757,GO:0032760,GO:0033036,GO:0034142,GO:0034145,GO:0043032,GO:0045087,GO:0045919,GO:0050829,GO:0050830,GO:0060265,GO:0070062,GO:0070891,GO:0071222,GO:0071223,GO:0071723,GO:0090023" lipopolysaccharide binding|toll-like receptor signaling pathway|leukocyte chemotaxis involved in inflammatory response|macrophage activation involved in immune response|signaling receptor binding|protein binding|extracellular region|extracellular space|acute-phase response|cellular defense response|opsonization|cell surface|lipopolysaccharide transport|membrane|cytokine-mediated signaling pathway|lipopolysaccharide-mediated signaling pathway|detection of molecule of bacterial origin|response to lipopolysaccharide|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|macromolecule localization|toll-like receptor 4 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of macrophage activation|innate immune response|positive regulation of cytolysis|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|positive regulation of respiratory burst involved in inflammatory response|extracellular exosome|lipoteichoic acid binding|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|lipopeptide binding|positive regulation of neutrophil chemotaxis "hsa04064,hsa04620,hsa05152" NF-kappa B signaling pathway|Toll-like receptor signaling pathway|Tuberculosis LBR 2403.424306 2550.054426 2256.794185 0.884998438 -0.176253186 0.456229011 1 30.66510093 26.68443928 3930 lamin B receptor "GO:0003677,GO:0003723,GO:0005515,GO:0005521,GO:0005634,GO:0005635,GO:0005637,GO:0005639,GO:0005737,GO:0005789,GO:0006695,GO:0016020,GO:0016021,GO:0016126,GO:0016627,GO:0030223,GO:0031965,GO:0050613,GO:0055114,GO:0070087,GO:0070402" "DNA binding|RNA binding|protein binding|lamin binding|nucleus|nuclear envelope|nuclear inner membrane|integral component of nuclear inner membrane|cytoplasm|endoplasmic reticulum membrane|cholesterol biosynthetic process|membrane|integral component of membrane|sterol biosynthetic process|oxidoreductase activity, acting on the CH-CH group of donors|neutrophil differentiation|nuclear membrane|delta14-sterol reductase activity|oxidation-reduction process|chromo shadow domain binding|NADPH binding" hsa00100 Steroid biosynthesis LBX1 124.1419894 117.5667687 130.71721 1.111855088 0.152968769 0.738788425 1 3.544814898 3.87536782 10660 ladybird homeobox 1 "GO:0000785,GO:0000981,GO:0001947,GO:0005515,GO:0005634,GO:0005667,GO:0006357,GO:0007517,GO:0008285,GO:0009653,GO:0021522,GO:0045665,GO:0048664,GO:1990837" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|heart looping|protein binding|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|muscle organ development|negative regulation of cell population proliferation|anatomical structure morphogenesis|spinal cord motor neuron differentiation|negative regulation of neuron differentiation|neuron fate determination|sequence-specific double-stranded DNA binding" LBX2 101.9611749 103.0009744 100.9213754 0.979809909 -0.029426212 0.972998481 1 3.190349794 3.073628031 85474 ladybird homeobox 2 "GO:0000785,GO:0000981,GO:0005634,GO:0006357,GO:0042692,GO:1904105,GO:1990837,GO:2000052" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|muscle cell differentiation|positive regulation of convergent extension involved in gastrulation|sequence-specific double-stranded DNA binding|positive regulation of non-canonical Wnt signaling pathway" LCA5 210.095636 191.4361544 228.7551175 1.194942085 0.256940697 0.476391334 1 2.181169026 2.56275658 167691 lebercilin LCA5 "GO:0005515,GO:0005929,GO:0005930,GO:0032391,GO:0036064,GO:0042073,GO:0044877,GO:0045494" protein binding|cilium|axoneme|photoreceptor connecting cilium|ciliary basal body|intraciliary transport|protein-containing complex binding|photoreceptor cell maintenance LCA5L 16.6912815 21.84869154 11.53387147 0.527897584 -0.921670032 0.325352197 1 0.225405859 0.117000052 150082 lebercilin LCA5 like "GO:0005515,GO:0005930,GO:0042073" protein binding|axoneme|intraciliary transport LCAT 69.85176912 80.11186896 59.59166927 0.743855686 -0.42690534 0.428923561 1 2.857903213 2.090294042 3931 lecithin-cholesterol acyltransferase "GO:0003847,GO:0004607,GO:0004806,GO:0005515,GO:0005576,GO:0005615,GO:0006629,GO:0006644,GO:0006656,GO:0008203,GO:0030301,GO:0034186,GO:0034364,GO:0034372,GO:0034375,GO:0034435,GO:0042158,GO:0042632,GO:0043691,GO:0046470,GO:0047179,GO:0070062,GO:0090107" 1-alkyl-2-acetylglycerophosphocholine esterase activity|phosphatidylcholine-sterol O-acyltransferase activity|triglyceride lipase activity|protein binding|extracellular region|extracellular space|lipid metabolic process|phospholipid metabolic process|phosphatidylcholine biosynthetic process|cholesterol metabolic process|cholesterol transport|apolipoprotein A-I binding|high-density lipoprotein particle|very-low-density lipoprotein particle remodeling|high-density lipoprotein particle remodeling|cholesterol esterification|lipoprotein biosynthetic process|cholesterol homeostasis|reverse cholesterol transport|phosphatidylcholine metabolic process|platelet-activating factor acetyltransferase activity|extracellular exosome|regulation of high-density lipoprotein particle assembly "hsa00564,hsa04979" Glycerophospholipid metabolism|Cholesterol metabolism LCLAT1 315.2025902 339.1749257 291.2302547 0.858643233 -0.219869281 0.481654199 1 2.940406499 2.4825117 253558 lysocardiolipin acyltransferase 1 "GO:0003841,GO:0005515,GO:0005783,GO:0005789,GO:0005829,GO:0006654,GO:0007275,GO:0008374,GO:0012505,GO:0016020,GO:0016021,GO:0016024,GO:0016746,GO:0035965,GO:0036149" "1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|phosphatidic acid biosynthetic process|multicellular organism development|O-acyltransferase activity|endomembrane system|membrane|integral component of membrane|CDP-diacylglycerol biosynthetic process|transferase activity, transferring acyl groups|cardiolipin acyl-chain remodeling|phosphatidylinositol acyl-chain remodeling" "hsa00561,hsa00564" Glycerolipid metabolism|Glycerophospholipid metabolism LCMT1 796.5857812 726.2088901 866.9626723 1.193819966 0.255585287 0.310693788 1 24.87575979 29.20023663 51451 leucine carboxyl methyltransferase 1 "GO:0000086,GO:0003880,GO:0005515,GO:0005654,GO:0005829,GO:0006464,GO:0006479,GO:0006481,GO:0008757,GO:0010906,GO:0018423,GO:0031333,GO:0042981,GO:0090266" G2/M transition of mitotic cell cycle|protein C-terminal carboxyl O-methyltransferase activity|protein binding|nucleoplasm|cytosol|cellular protein modification process|protein methylation|C-terminal protein methylation|S-adenosylmethionine-dependent methyltransferase activity|regulation of glucose metabolic process|protein C-terminal leucine carboxyl O-methyltransferase activity|negative regulation of protein-containing complex assembly|regulation of apoptotic process|regulation of mitotic cell cycle spindle assembly checkpoint LCMT2 202.1931522 223.6889848 180.6973197 0.80780607 -0.307919108 0.398157165 1 1.723880144 1.369258224 9836 leucine carboxyl methyltransferase 2 "GO:0005515,GO:0005737,GO:0006400,GO:0008175,GO:0030488,GO:0031591" protein binding|cytoplasm|tRNA modification|tRNA methyltransferase activity|tRNA methylation|wybutosine biosynthetic process LCN1 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.060484724 0.219768071 3933 lipocalin 1 "GO:0001895,GO:0004869,GO:0005102,GO:0005515,GO:0005549,GO:0005576,GO:0005615,GO:0006508,GO:0008270,GO:0010951,GO:0015909,GO:0031404,GO:0036094,GO:0050896,GO:0050909" retina homeostasis|cysteine-type endopeptidase inhibitor activity|signaling receptor binding|protein binding|odorant binding|extracellular region|extracellular space|proteolysis|zinc ion binding|negative regulation of endopeptidase activity|long-chain fatty acid transport|chloride ion binding|small molecule binding|response to stimulus|sensory perception of taste LCN10 3.923881751 2.080827765 5.766935736 2.771462315 1.470647391 0.503574097 1 0.055664137 0.151689541 414332 lipocalin 10 "GO:0005576,GO:0036094" extracellular region|small molecule binding LCN12 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.041236522 0.056186527 286256 lipocalin 12 "GO:0001972,GO:0005549,GO:0005576,GO:0005615,GO:0015909" retinoic acid binding|odorant binding|extracellular region|extracellular space|long-chain fatty acid transport LCN2 251.7210233 451.5396251 51.90242162 0.114945442 -3.12097884 6.75E-17 4.62E-13 29.38760963 3.321445985 3934 lipocalin 2 "GO:0005506,GO:0005515,GO:0005549,GO:0005576,GO:0005615,GO:0006879,GO:0006915,GO:0015891,GO:0019221,GO:0019730,GO:0035580,GO:0036094,GO:0042742,GO:0042802,GO:0043312,GO:0045087,GO:0070062,GO:0097577,GO:0120162,GO:1903981" iron ion binding|protein binding|odorant binding|extracellular region|extracellular space|cellular iron ion homeostasis|apoptotic process|siderophore transport|cytokine-mediated signaling pathway|antimicrobial humoral response|specific granule lumen|small molecule binding|defense response to bacterium|identical protein binding|neutrophil degranulation|innate immune response|extracellular exosome|sequestering of iron ion|positive regulation of cold-induced thermogenesis|enterobactin binding hsa04657 IL-17 signaling pathway LCOR 2365.877514 2106.838112 2624.916916 1.24590347 0.317192296 0.179690203 1 4.382696467 5.369044058 84458 ligand dependent nuclear receptor corepressor "GO:0000122,GO:0001226,GO:0003677,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0030331,GO:0042826,GO:0071392,GO:1990226,GO:1990381" negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription corepressor binding|DNA binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|estrogen receptor binding|histone deacetylase binding|cellular response to estradiol stimulus|histone methyltransferase binding|ubiquitin-specific protease binding LCORL 710.8007113 631.5312268 790.0701958 1.251039002 0.323126768 0.206471442 1 2.05309825 2.525525517 254251 ligand dependent nuclear receptor corepressor like "GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:1990226" DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|histone methyltransferase binding LCP1 258.2220165 319.407062 197.036971 0.616883577 -0.696929856 0.035329767 0.95006405 4.555362868 2.763104846 3936 lymphocyte cytosolic protein 1 "GO:0001725,GO:0001726,GO:0001891,GO:0002102,GO:0002286,GO:0003779,GO:0005178,GO:0005509,GO:0005615,GO:0005737,GO:0005829,GO:0005884,GO:0005886,GO:0005925,GO:0010737,GO:0015629,GO:0016477,GO:0022617,GO:0030054,GO:0030175,GO:0030866,GO:0031100,GO:0032432,GO:0032587,GO:0033157,GO:0035722,GO:0042802,GO:0044319,GO:0048471,GO:0051015,GO:0051017,GO:0051020,GO:0051639,GO:0051764,GO:0070062,GO:0071803" "stress fiber|ruffle|phagocytic cup|podosome|T cell activation involved in immune response|actin binding|integrin binding|calcium ion binding|extracellular space|cytoplasm|cytosol|actin filament|plasma membrane|focal adhesion|protein kinase A signaling|actin cytoskeleton|cell migration|extracellular matrix disassembly|cell junction|filopodium|cortical actin cytoskeleton organization|animal organ regeneration|actin filament bundle|ruffle membrane|regulation of intracellular protein transport|interleukin-12-mediated signaling pathway|identical protein binding|wound healing, spreading of cells|perinuclear region of cytoplasm|actin filament binding|actin filament bundle assembly|GTPase binding|actin filament network formation|actin crosslink formation|extracellular exosome|positive regulation of podosome assembly" LCTL 3.522561699 4.161655531 2.883467868 0.692865579 -0.529352609 0.940314863 1 0.061117201 0.041637402 197021 lactase like "GO:0002089,GO:0005783,GO:0005789,GO:0005903,GO:0005975,GO:0007601,GO:0008422,GO:0016021,GO:0050896" lens morphogenesis in camera-type eye|endoplasmic reticulum|endoplasmic reticulum membrane|brush border|carbohydrate metabolic process|visual perception|beta-glucosidase activity|integral component of membrane|response to stimulus LDAH 658.0755279 685.6327487 630.5183071 0.919615214 -0.12089776 0.643803585 1 9.291762229 8.401859489 60526 lipid droplet associated hydrolase "GO:0005783,GO:0005811,GO:0016042,GO:0016298,GO:0019915" endoplasmic reticulum|lipid droplet|lipid catabolic process|lipase activity|lipid storage LDB1 3251.238202 3359.496427 3142.979976 0.935550921 -0.096111915 0.685817291 1 48.13158384 44.27603909 8861 LIM domain binding 1 "GO:0000122,GO:0000785,GO:0000972,GO:0001102,GO:0001702,GO:0001942,GO:0003677,GO:0003682,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006355,GO:0006366,GO:0007275,GO:0007399,GO:0009948,GO:0010669,GO:0016055,GO:0019899,GO:0021702,GO:0022607,GO:0030182,GO:0030274,GO:0030334,GO:0031252,GO:0032991,GO:0034243,GO:0035019,GO:0042803,GO:0043549,GO:0043621,GO:0043973,GO:0045647,GO:0045785,GO:0045892,GO:0045944,GO:0046985,GO:0048382,GO:0051893,GO:0140297,GO:1902036,GO:1990907" "negative regulation of transcription by RNA polymerase II|chromatin|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|RNA polymerase II activating transcription factor binding|gastrulation with mouth forming second|hair follicle development|DNA binding|chromatin binding|transcription coregulator activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription, DNA-templated|transcription by RNA polymerase II|multicellular organism development|nervous system development|anterior/posterior axis specification|epithelial structure maintenance|Wnt signaling pathway|enzyme binding|cerebellar Purkinje cell differentiation|cellular component assembly|neuron differentiation|LIM domain binding|regulation of cell migration|cell leading edge|protein-containing complex|regulation of transcription elongation from RNA polymerase II promoter|somatic stem cell population maintenance|protein homodimerization activity|regulation of kinase activity|protein self-association|histone H3-K4 acetylation|negative regulation of erythrocyte differentiation|positive regulation of cell adhesion|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of hemoglobin biosynthetic process|mesendoderm development|regulation of focal adhesion assembly|DNA-binding transcription factor binding|regulation of hematopoietic stem cell differentiation|beta-catenin-TCF complex" hsa05202 Transcriptional misregulation in cancer LDB2 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.047484302 0.014377643 9079 LIM domain binding 2 "GO:0000122,GO:0001102,GO:0001942,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005886,GO:0007399,GO:0010669,GO:0019899,GO:0030274,GO:0030334,GO:0031252,GO:0035019,GO:0043549,GO:0044089,GO:0045944" negative regulation of transcription by RNA polymerase II|RNA polymerase II activating transcription factor binding|hair follicle development|transcription coregulator activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|plasma membrane|nervous system development|epithelial structure maintenance|enzyme binding|LIM domain binding|regulation of cell migration|cell leading edge|somatic stem cell population maintenance|regulation of kinase activity|positive regulation of cellular component biogenesis|positive regulation of transcription by RNA polymerase II LDHA 32601.46262 25411.06867 39791.85658 1.565926136 0.647016163 0.030705452 0.895820653 542.2399166 834.8989907 3939 lactate dehydrogenase A "GO:0001666,GO:0004459,GO:0005515,GO:0005634,GO:0005829,GO:0006089,GO:0006090,GO:0006096,GO:0007584,GO:0009749,GO:0016020,GO:0019674,GO:0019900,GO:0042493,GO:0042542,GO:0042802,GO:0043065,GO:0043627,GO:0045296,GO:0048569,GO:0051287,GO:0051591,GO:0055114,GO:0070062" response to hypoxia|L-lactate dehydrogenase activity|protein binding|nucleus|cytosol|lactate metabolic process|pyruvate metabolic process|glycolytic process|response to nutrient|response to glucose|membrane|NAD metabolic process|kinase binding|response to drug|response to hydrogen peroxide|identical protein binding|positive regulation of apoptotic process|response to estrogen|cadherin binding|post-embryonic animal organ development|NAD binding|response to cAMP|oxidation-reduction process|extracellular exosome "hsa00010,hsa00270,hsa00620,hsa00640,hsa04066,hsa04922,hsa05230" Glycolysis / Gluconeogenesis|Cysteine and methionine metabolism|Pyruvate metabolism|Propanoate metabolism|HIF-1 signaling pathway|Glucagon signaling pathway|Central carbon metabolism in cancer LDHB 14023.39312 13200.77134 14846.0149 1.12463238 0.16945349 0.515254705 1 360.358519 398.4891999 3945 lactate dehydrogenase B "GO:0004459,GO:0005515,GO:0005737,GO:0005829,GO:0005975,GO:0006090,GO:0016020,GO:0042802,GO:0045121,GO:0055114,GO:0070062" L-lactate dehydrogenase activity|protein binding|cytoplasm|cytosol|carbohydrate metabolic process|pyruvate metabolic process|membrane|identical protein binding|membrane raft|oxidation-reduction process|extracellular exosome "hsa00010,hsa00270,hsa00620,hsa00640,hsa04066,hsa04922,hsa05230" Glycolysis / Gluconeogenesis|Cysteine and methionine metabolism|Pyruvate metabolism|Propanoate metabolism|HIF-1 signaling pathway|Glucagon signaling pathway|Central carbon metabolism in cancer LDHD 36.07291648 26.01034707 46.13548589 1.773735882 0.826791201 0.22596565 1 0.606697735 1.058114105 197257 lactate dehydrogenase D "GO:0004458,GO:0005515,GO:0005739,GO:0005743,GO:0008720,GO:0050660,GO:0055114,GO:0071949,GO:1903457" D-lactate dehydrogenase (cytochrome) activity|protein binding|mitochondrion|mitochondrial inner membrane|D-lactate dehydrogenase activity|flavin adenine dinucleotide binding|oxidation-reduction process|FAD binding|lactate catabolic process hsa00620 Pyruvate metabolism LDLR 1706.30246 1962.220583 1450.384338 0.739154584 -0.43605198 0.06634771 1 20.12300271 14.62511328 3949 low density lipoprotein receptor "GO:0001540,GO:0001618,GO:0002020,GO:0005041,GO:0005509,GO:0005515,GO:0005764,GO:0005769,GO:0005770,GO:0005794,GO:0005886,GO:0005887,GO:0005905,GO:0006629,GO:0006897,GO:0006898,GO:0006909,GO:0007616,GO:0008203,GO:0009897,GO:0009986,GO:0010008,GO:0010867,GO:0010899,GO:0015914,GO:0016020,GO:0016323,GO:0030169,GO:0030229,GO:0030299,GO:0030301,GO:0030669,GO:0032050,GO:0034362,GO:0034381,GO:0034382,GO:0034383,GO:0036020,GO:0042632,GO:0042802,GO:0043235,GO:0045177,GO:0046718,GO:0051246,GO:0051248,GO:0061024,GO:0061771,GO:0061889,GO:0070508,GO:0071404,GO:0090118,GO:0097242,GO:0150094,GO:1903979,GO:1905167,GO:1905907,GO:1990666" amyloid-beta binding|virus receptor activity|protease binding|low-density lipoprotein particle receptor activity|calcium ion binding|protein binding|lysosome|early endosome|late endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|clathrin-coated pit|lipid metabolic process|endocytosis|receptor-mediated endocytosis|phagocytosis|long-term memory|cholesterol metabolic process|external side of plasma membrane|cell surface|endosome membrane|positive regulation of triglyceride biosynthetic process|regulation of phosphatidylcholine catabolic process|phospholipid transport|membrane|basolateral plasma membrane|low-density lipoprotein particle binding|very-low-density lipoprotein particle receptor activity|intestinal cholesterol absorption|cholesterol transport|clathrin-coated endocytic vesicle membrane|clathrin heavy chain binding|low-density lipoprotein particle|plasma lipoprotein particle clearance|chylomicron remnant clearance|low-density lipoprotein particle clearance|endolysosome membrane|cholesterol homeostasis|identical protein binding|receptor complex|apical part of cell|viral entry into host cell|regulation of protein metabolic process|negative regulation of protein metabolic process|membrane organization|response to caloric restriction|negative regulation of astrocyte activation|cholesterol import|cellular response to low-density lipoprotein particle stimulus|receptor-mediated endocytosis involved in cholesterol transport|amyloid-beta clearance|amyloid-beta clearance by cellular catabolic process|negative regulation of microglial cell activation|positive regulation of lysosomal protein catabolic process|negative regulation of amyloid fibril formation|PCSK9-LDLR complex "hsa04144,hsa04913,hsa04925,hsa04927,hsa04934,hsa04976,hsa04979,hsa05145,hsa05160" Endocytosis|Ovarian steroidogenesis|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome|Bile secretion|Cholesterol metabolism|Toxoplasmosis|Hepatitis C LDLRAD3 567.4104507 576.389291 558.4316104 0.968844528 -0.045662923 0.87003992 1 7.827185013 7.456428688 143458 low density lipoprotein receptor class A domain containing 3 "GO:0001540,GO:0005886,GO:0006898,GO:0016021,GO:0070613" amyloid-beta binding|plasma membrane|receptor-mediated endocytosis|integral component of membrane|regulation of protein processing LDLRAP1 313.2110812 312.1241648 314.2979976 1.006964641 0.010013025 0.985974502 1 2.616634153 2.590767289 26119 low density lipoprotein receptor adaptor protein 1 "GO:0001540,GO:0001784,GO:0005515,GO:0005546,GO:0005769,GO:0005829,GO:0005883,GO:0005886,GO:0006898,GO:0008203,GO:0009898,GO:0009925,GO:0030159,GO:0030276,GO:0030301,GO:0030424,GO:0030665,GO:0031623,GO:0034383,GO:0035591,GO:0035612,GO:0035615,GO:0035650,GO:0042632,GO:0042982,GO:0043393,GO:0048260,GO:0050750,GO:0055037,GO:0061024,GO:0071345,GO:0090118,GO:0090205,GO:1903076,GO:1904707,GO:1905581,GO:1905602" "amyloid-beta binding|phosphotyrosine residue binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|early endosome|cytosol|neurofilament|plasma membrane|receptor-mediated endocytosis|cholesterol metabolic process|cytoplasmic side of plasma membrane|basal plasma membrane|signaling receptor complex adaptor activity|clathrin binding|cholesterol transport|axon|clathrin-coated vesicle membrane|receptor internalization|low-density lipoprotein particle clearance|signaling adaptor activity|AP-2 adaptor complex binding|clathrin adaptor activity|AP-1 adaptor complex binding|cholesterol homeostasis|amyloid precursor protein metabolic process|regulation of protein binding|positive regulation of receptor-mediated endocytosis|low-density lipoprotein particle receptor binding|recycling endosome|membrane organization|cellular response to cytokine stimulus|receptor-mediated endocytosis involved in cholesterol transport|positive regulation of cholesterol metabolic process|regulation of protein localization to plasma membrane|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of low-density lipoprotein particle clearance|positive regulation of receptor-mediated endocytosis involved in cholesterol transport" "hsa04144,hsa04979" Endocytosis|Cholesterol metabolism LDOC1 3412.571435 2914.199285 3910.943585 1.342030246 0.424417187 0.073823383 1 39.92951471 52.68991701 23641 LDOC1 regulator of NFKB signaling "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0008285,GO:0071222,GO:0071225" protein binding|nucleus|nucleoplasm|nucleolus|negative regulation of cell population proliferation|cellular response to lipopolysaccharide|cellular response to muramyl dipeptide LEAP2 8.566115259 10.40413883 6.728091692 0.64667454 -0.628888283 0.669388466 1 0.644889393 0.41005506 116842 liver enriched antimicrobial peptide 2 "GO:0005576,GO:0019730,GO:0042742" extracellular region|antimicrobial humoral response|defense response to bacterium LEF1 274.7453357 261.1438845 288.3467868 1.104168253 0.142960027 0.667182278 1 5.086412101 5.522274346 51176 lymphoid enhancer binding factor 1 "GO:0000122,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001569,GO:0001649,GO:0001756,GO:0001837,GO:0002040,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006357,GO:0007223,GO:0008013,GO:0008284,GO:0008301,GO:0010628,GO:0010718,GO:0021542,GO:0021861,GO:0021873,GO:0021943,GO:0030111,GO:0030223,GO:0030284,GO:0030326,GO:0030331,GO:0030335,GO:0030509,GO:0030854,GO:0030879,GO:0032696,GO:0032713,GO:0032714,GO:0032993,GO:0033153,GO:0042100,GO:0042393,GO:0042475,GO:0042826,GO:0043066,GO:0043392,GO:0043401,GO:0043565,GO:0043586,GO:0043923,GO:0043966,GO:0043967,GO:0045063,GO:0045295,GO:0045588,GO:0045843,GO:0045892,GO:0045893,GO:0045944,GO:0048341,GO:0050909,GO:0060033,GO:0060070,GO:0060325,GO:0060326,GO:0060710,GO:0061153,GO:0062009,GO:0070016,GO:0070742,GO:0071345,GO:0071353,GO:0071864,GO:0071866,GO:0071899,GO:1902262,GO:1904837,GO:1990837,GO:1990907" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|branching involved in blood vessel morphogenesis|osteoblast differentiation|somitogenesis|epithelial to mesenchymal transition|sprouting angiogenesis|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|regulation of transcription by RNA polymerase II|Wnt signaling pathway, calcium modulating pathway|beta-catenin binding|positive regulation of cell population proliferation|DNA binding, bending|positive regulation of gene expression|positive regulation of epithelial to mesenchymal transition|dentate gyrus development|forebrain radial glial cell differentiation|forebrain neuroblast division|formation of radial glial scaffolds|regulation of Wnt signaling pathway|neutrophil differentiation|estrogen receptor activity|embryonic limb morphogenesis|estrogen receptor binding|positive regulation of cell migration|BMP signaling pathway|positive regulation of granulocyte differentiation|mammary gland development|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|protein-DNA complex|T cell receptor V(D)J recombination|B cell proliferation|histone binding|odontogenesis of dentin-containing tooth|histone deacetylase binding|negative regulation of apoptotic process|negative regulation of DNA binding|steroid hormone mediated signaling pathway|sequence-specific DNA binding|tongue development|positive regulation by host of viral transcription|histone H3 acetylation|histone H4 acetylation|T-helper 1 cell differentiation|gamma-catenin binding|positive regulation of gamma-delta T cell differentiation|negative regulation of striated muscle tissue development|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|paraxial mesoderm formation|sensory perception of taste|anatomical structure regression|canonical Wnt signaling pathway|face morphogenesis|cell chemotaxis|chorio-allantoic fusion|trachea gland development|secondary palate development|armadillo repeat domain binding|C2H2 zinc finger domain binding|cellular response to cytokine stimulus|cellular response to interleukin-4|positive regulation of cell proliferation in bone marrow|negative regulation of apoptotic process in bone marrow cell|negative regulation of estrogen receptor binding|apoptotic process involved in blood vessel morphogenesis|beta-catenin-TCF complex assembly|sequence-specific double-stranded DNA binding|beta-catenin-TCF complex" "hsa04310,hsa04390,hsa04520,hsa04916,hsa04934,hsa05132,hsa05167,hsa05200,hsa05210,hsa05213,hsa05215,hsa05216,hsa05217,hsa05221,hsa05224,hsa05225,hsa05226,hsa05412" Wnt signaling pathway|Hippo signaling pathway|Adherens junction|Melanogenesis|Cushing syndrome|Salmonella infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy HMG LEKR1 6.564545421 8.323311061 4.80577978 0.577387982 -0.792387015 0.636893371 1 0.070631231 0.040099199 389170 "leucine, glutamate and lysine rich 1" LEMD2 882.7275118 830.2502783 935.2047452 1.126413046 0.171735949 0.491762945 1 5.446033852 6.031831306 221496 LEM domain nuclear envelope protein 2 "GO:0000785,GO:0005515,GO:0005635,GO:0005637,GO:0005639,GO:0005783,GO:0006998,GO:0016020,GO:0016021,GO:0022008,GO:0030514,GO:0031490,GO:0031965,GO:0035914,GO:0043409,GO:0051898,GO:0060914,GO:0071168" chromatin|protein binding|nuclear envelope|nuclear inner membrane|integral component of nuclear inner membrane|endoplasmic reticulum|nuclear envelope organization|membrane|integral component of membrane|neurogenesis|negative regulation of BMP signaling pathway|chromatin DNA binding|nuclear membrane|skeletal muscle cell differentiation|negative regulation of MAPK cascade|negative regulation of protein kinase B signaling|heart formation|protein localization to chromatin LEMD3 661.1722318 653.3799183 668.9645454 1.02385232 0.034007637 0.901291039 1 7.294913259 7.343931708 23592 LEM domain containing 3 "GO:0005515,GO:0005637,GO:0005639,GO:0006998,GO:0016020,GO:0016021,GO:0030512,GO:0030514,GO:0031490,GO:0031965,GO:0032926,GO:1902531" protein binding|nuclear inner membrane|integral component of nuclear inner membrane|nuclear envelope organization|membrane|integral component of membrane|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|chromatin DNA binding|nuclear membrane|negative regulation of activin receptor signaling pathway|regulation of intracellular signal transduction LENG1 134.9474483 136.2942186 133.6006779 0.980237307 -0.028797039 0.964913372 1 5.267032549 5.076546965 79165 leukocyte receptor cluster member 1 "GO:0003674,GO:0005515,GO:0005575,GO:0008150" molecular_function|protein binding|cellular_component|biological_process LENG8 2213.211619 2211.919914 2214.503323 1.001167948 0.00168401 0.996516664 1 15.60630625 15.3630782 114823 leukocyte receptor cluster member 8 "GO:0005515,GO:0005634" protein binding|nucleus LENG9 50.11850389 54.1015219 46.13548589 0.852757635 -0.229792327 0.725447661 1 1.410502584 1.182689337 94059 leukocyte receptor cluster member 9 GO:0046872 metal ion binding LEO1 427.5980864 388.0743782 467.1217946 1.203691408 0.267465573 0.348067892 1 9.047975673 10.70872493 123169 "LEO1 homolog, Paf1/RNA polymerase II complex component" "GO:0001650,GO:0001711,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0006366,GO:0006368,GO:0006378,GO:0010390,GO:0016055,GO:0016567,GO:0016593,GO:0019827,GO:0031442,GO:0032968,GO:0033523,GO:0045638,GO:1904837,GO:1990269" fibrillar center|endodermal cell fate commitment|protein binding|nucleus|nucleoplasm|centrosome|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|mRNA polyadenylation|histone monoubiquitination|Wnt signaling pathway|protein ubiquitination|Cdc73/Paf1 complex|stem cell population maintenance|positive regulation of mRNA 3'-end processing|positive regulation of transcription elongation from RNA polymerase II promoter|histone H2B ubiquitination|negative regulation of myeloid cell differentiation|beta-catenin-TCF complex assembly|RNA polymerase II C-terminal domain phosphoserine binding LEPR 482.9287206 427.6101058 538.2473354 1.258733898 0.331973323 0.228813252 1 2.071037792 2.563262775 3953 leptin receptor "GO:0001525,GO:0001934,GO:0004888,GO:0004896,GO:0005515,GO:0005576,GO:0005977,GO:0006112,GO:0006909,GO:0007166,GO:0007275,GO:0008203,GO:0009897,GO:0010507,GO:0014009,GO:0016021,GO:0016323,GO:0017046,GO:0019221,GO:0019953,GO:0019955,GO:0030217,GO:0033210,GO:0038021,GO:0042593,GO:0042802,GO:0043235,GO:0044321,GO:0045721,GO:0046850,GO:0051049,GO:0051346,GO:0060259,GO:0097009,GO:0098868,GO:0120162,GO:0150104" angiogenesis|positive regulation of protein phosphorylation|transmembrane signaling receptor activity|cytokine receptor activity|protein binding|extracellular region|glycogen metabolic process|energy reserve metabolic process|phagocytosis|cell surface receptor signaling pathway|multicellular organism development|cholesterol metabolic process|external side of plasma membrane|negative regulation of autophagy|glial cell proliferation|integral component of membrane|basolateral plasma membrane|peptide hormone binding|cytokine-mediated signaling pathway|sexual reproduction|cytokine binding|T cell differentiation|leptin-mediated signaling pathway|leptin receptor activity|glucose homeostasis|identical protein binding|receptor complex|response to leptin|negative regulation of gluconeogenesis|regulation of bone remodeling|regulation of transport|negative regulation of hydrolase activity|regulation of feeding behavior|energy homeostasis|bone growth|positive regulation of cold-induced thermogenesis|transport across blood-brain barrier "hsa04060,hsa04080,hsa04152,hsa04630,hsa04920,hsa04932" Cytokine-cytokine receptor interaction|Neuroactive ligand-receptor interaction|AMPK signaling pathway|JAK-STAT signaling pathway|Adipocytokine signaling pathway|Non-alcoholic fatty liver disease LEPROT 1618.403807 1547.095443 1689.712171 1.092183535 0.127215313 0.594035366 1 16.84669259 18.09178654 54741 leptin receptor overlapping transcript "GO:0000139,GO:0005102,GO:0005515,GO:0005768,GO:0005794,GO:0010008,GO:0016021,GO:0032511,GO:0046426,GO:0060400,GO:1903955,GO:2000009" Golgi membrane|signaling receptor binding|protein binding|endosome|Golgi apparatus|endosome membrane|integral component of membrane|late endosome to vacuole transport via multivesicular body sorting pathway|negative regulation of receptor signaling pathway via JAK-STAT|negative regulation of growth hormone receptor signaling pathway|positive regulation of protein targeting to mitochondrion|negative regulation of protein localization to cell surface LEPROTL1 693.4300926 705.4006124 681.4595728 0.966060365 -0.049814756 0.851311223 1 8.878758069 8.433884812 23484 leptin receptor overlapping transcript like 1 "GO:0005515,GO:0005768,GO:0016021,GO:0032511,GO:0042802,GO:2000009" protein binding|endosome|integral component of membrane|late endosome to vacuole transport via multivesicular body sorting pathway|identical protein binding|negative regulation of protein localization to cell surface LETM1 759.8140203 744.93634 774.6917005 1.039943494 0.056505141 0.828162664 1 7.694190697 7.867628899 3954 leucine zipper and EF-hand containing transmembrane protein 1 "GO:0005509,GO:0005515,GO:0005739,GO:0005743,GO:0006851,GO:0006875,GO:0015369,GO:0016021,GO:0034214,GO:0042407,GO:0043022,GO:0051260,GO:0051560,GO:0051562,GO:0099093,GO:1900069" calcium ion binding|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial calcium ion transmembrane transport|cellular metal ion homeostasis|calcium:proton antiporter activity|integral component of membrane|protein hexamerization|cristae formation|ribosome binding|protein homooligomerization|mitochondrial calcium ion homeostasis|negative regulation of mitochondrial calcium ion concentration|calcium export from the mitochondrion|regulation of cellular hyperosmotic salinity response LETM2 299.7152689 311.0837509 288.3467868 0.926910473 -0.109498094 0.735967509 1 2.415534416 2.201517781 137994 leucine zipper and EF-hand containing transmembrane protein 2 "GO:0005743,GO:0006875,GO:0016021,GO:0043022" mitochondrial inner membrane|cellular metal ion homeostasis|integral component of membrane|ribosome binding LETMD1 2456.937038 2529.246149 2384.627927 0.94282161 -0.084943268 0.720437802 1 29.07198329 26.95102999 25875 LETM1 domain containing 1 "GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0005741,GO:0016021,GO:0043022" protein binding|nucleoplasm|nucleolus|mitochondrion|mitochondrial outer membrane|integral component of membrane|ribosome binding LFNG 16.97371467 16.64662212 17.30080721 1.039298368 0.055609892 1 1 0.275302023 0.281333097 3955 LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase "GO:0001756,GO:0002315,GO:0005576,GO:0008375,GO:0008593,GO:0009887,GO:0014807,GO:0030173,GO:0030217,GO:0033829,GO:0046872,GO:1902367,GO:1903561" somitogenesis|marginal zone B cell differentiation|extracellular region|acetylglucosaminyltransferase activity|regulation of Notch signaling pathway|animal organ morphogenesis|regulation of somitogenesis|integral component of Golgi membrane|T cell differentiation|O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity|metal ion binding|negative regulation of Notch signaling pathway involved in somitogenesis|extracellular vesicle "hsa00514,hsa04330,hsa05165" Other types of O-glycan biosynthesis|Notch signaling pathway|Human papillomavirus infection LGALS1 19725.28982 17675.59145 21774.98818 1.231924162 0.300913445 0.269936016 1 1786.579222 2164.100526 3956 galectin 1 "GO:0002317,GO:0003723,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005788,GO:0005829,GO:0006915,GO:0009986,GO:0010812,GO:0010977,GO:0030246,GO:0030395,GO:0031295,GO:0034120,GO:0035900,GO:0042493,GO:0042802,GO:0042981,GO:0043123,GO:0043236,GO:0043687,GO:0044267,GO:0045445,GO:0046598,GO:0048678,GO:0062023,GO:0070062,GO:0071333,GO:0071407,GO:2001200" plasma cell differentiation|RNA binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|endoplasmic reticulum lumen|cytosol|apoptotic process|cell surface|negative regulation of cell-substrate adhesion|negative regulation of neuron projection development|carbohydrate binding|lactose binding|T cell costimulation|positive regulation of erythrocyte aggregation|response to isolation stress|response to drug|identical protein binding|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|laminin binding|post-translational protein modification|cellular protein metabolic process|myoblast differentiation|positive regulation of viral entry into host cell|response to axon injury|collagen-containing extracellular matrix|extracellular exosome|cellular response to glucose stimulus|cellular response to organic cyclic compound|positive regulation of dendritic cell differentiation LGALS3 1113.616334 1100.757888 1126.47478 1.023362896 0.033317832 0.894880973 1 58.8042296 59.17106828 3958 galectin 3 "GO:0001772,GO:0002548,GO:0003723,GO:0004864,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005681,GO:0005737,GO:0005743,GO:0005886,GO:0006397,GO:0008380,GO:0009986,GO:0016020,GO:0019863,GO:0019903,GO:0030246,GO:0030593,GO:0030667,GO:0030855,GO:0031334,GO:0042056,GO:0042129,GO:0043236,GO:0043312,GO:0045087,GO:0045637,GO:0045806,GO:0048245,GO:0048246,GO:0050860,GO:0050918,GO:0062023,GO:0070062,GO:0070232,GO:0071674,GO:0071677,GO:0090280,GO:0101003,GO:1902041,GO:1903078,GO:1903614,GO:2000521,GO:2001189,GO:2001200,GO:2001237" immunological synapse|monocyte chemotaxis|RNA binding|protein phosphatase inhibitor activity|protein binding|extracellular region|extracellular space|nucleus|spliceosomal complex|cytoplasm|mitochondrial inner membrane|plasma membrane|mRNA processing|RNA splicing|cell surface|membrane|IgE binding|protein phosphatase binding|carbohydrate binding|neutrophil chemotaxis|secretory granule membrane|epithelial cell differentiation|positive regulation of protein-containing complex assembly|chemoattractant activity|regulation of T cell proliferation|laminin binding|neutrophil degranulation|innate immune response|regulation of myeloid cell differentiation|negative regulation of endocytosis|eosinophil chemotaxis|macrophage chemotaxis|negative regulation of T cell receptor signaling pathway|positive chemotaxis|collagen-containing extracellular matrix|extracellular exosome|regulation of T cell apoptotic process|mononuclear cell migration|positive regulation of mononuclear cell migration|positive regulation of calcium ion import|ficolin-1-rich granule membrane|regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of protein localization to plasma membrane|negative regulation of protein tyrosine phosphatase activity|negative regulation of immunological synapse formation|negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|positive regulation of dendritic cell differentiation|negative regulation of extrinsic apoptotic signaling pathway LGALS3BP 5696.184099 6129.078183 5263.290015 0.858740884 -0.219705216 0.363021219 1 148.5457029 125.4276864 3959 galectin 3 binding protein "GO:0002576,GO:0005044,GO:0005515,GO:0005576,GO:0005615,GO:0006897,GO:0006968,GO:0007155,GO:0007165,GO:0016020,GO:0031089,GO:0062023,GO:0070062,GO:0072562" platelet degranulation|scavenger receptor activity|protein binding|extracellular region|extracellular space|endocytosis|cellular defense response|cell adhesion|signal transduction|membrane|platelet dense granule lumen|collagen-containing extracellular matrix|extracellular exosome|blood microparticle LGALS8 2139.678158 2224.404881 2054.951434 0.923820772 -0.11431511 0.629751244 1 12.44886747 11.30807669 3964 galectin 8 "GO:0005178,GO:0005515,GO:0005615,GO:0005737,GO:0005829,GO:0016020,GO:0030246,GO:0031410,GO:0098586,GO:0098792,GO:1904977" integrin binding|protein binding|extracellular space|cytoplasm|cytosol|membrane|carbohydrate binding|cytoplasmic vesicle|cellular response to virus|xenophagy|lymphatic endothelial cell migration LGALSL 325.418645 329.8112008 321.0260893 0.973363211 -0.038949848 0.909284418 1 4.564682993 4.368745324 29094 galectin like "GO:0005515,GO:0030246" protein binding|carbohydrate binding LGI4 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.064168922 163175 leucine rich repeat LGI family member 4 "GO:0005576,GO:0005615,GO:0008344,GO:0014009,GO:0022011,GO:0031641,GO:0042551" extracellular region|extracellular space|adult locomotory behavior|glial cell proliferation|myelination in peripheral nervous system|regulation of myelination|neuron maturation LGMN 978.9362278 996.7164996 961.155956 0.964322309 -0.052412671 0.835222469 1 23.44333526 22.2286348 5641 legumain "GO:0002224,GO:0003014,GO:0004197,GO:0005576,GO:0005737,GO:0005764,GO:0005770,GO:0006508,GO:0006624,GO:0007613,GO:0008233,GO:0008284,GO:0008306,GO:0010447,GO:0010629,GO:0019886,GO:0032801,GO:0035729,GO:0036021,GO:0040015,GO:0042359,GO:0043202,GO:0043524,GO:0045177,GO:0045931,GO:0048156,GO:0048471,GO:0051603,GO:0070062,GO:0071277,GO:0090026,GO:0097061,GO:0097202,GO:0097264,GO:1900273,GO:1901185,GO:1904646,GO:2001028" toll-like receptor signaling pathway|renal system process|cysteine-type endopeptidase activity|extracellular region|cytoplasm|lysosome|late endosome|proteolysis|vacuolar protein processing|memory|peptidase activity|positive regulation of cell population proliferation|associative learning|response to acidic pH|negative regulation of gene expression|antigen processing and presentation of exogenous peptide antigen via MHC class II|receptor catabolic process|cellular response to hepatocyte growth factor stimulus|endolysosome lumen|negative regulation of multicellular organism growth|vitamin D metabolic process|lysosomal lumen|negative regulation of neuron apoptotic process|apical part of cell|positive regulation of mitotic cell cycle|tau protein binding|perinuclear region of cytoplasm|proteolysis involved in cellular protein catabolic process|extracellular exosome|cellular response to calcium ion|positive regulation of monocyte chemotaxis|dendritic spine organization|activation of cysteine-type endopeptidase activity|self proteolysis|positive regulation of long-term synaptic potentiation|negative regulation of ERBB signaling pathway|cellular response to amyloid-beta|positive regulation of endothelial cell chemotaxis "hsa04142,hsa04612" Lysosome|Antigen processing and presentation LGR4 1224.832408 1194.395137 1255.269679 1.050966836 0.071717145 0.769394111 1 12.14146158 12.54674756 55366 leucine rich repeat containing G protein-coupled receptor 4 "GO:0001649,GO:0001818,GO:0001942,GO:0004888,GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0007189,GO:0007190,GO:0007283,GO:0008528,GO:0009755,GO:0016500,GO:0030282,GO:0030539,GO:0032922,GO:0034122,GO:0036335,GO:0045087,GO:0045892,GO:0045893,GO:0046849,GO:0048565,GO:0061290,GO:0072202,GO:0072224,GO:0072282,GO:0090190,GO:0090263,GO:0120163,GO:2001013" "osteoblast differentiation|negative regulation of cytokine production|hair follicle development|transmembrane signaling receptor activity|G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|spermatogenesis|G protein-coupled peptide receptor activity|hormone-mediated signaling pathway|protein-hormone receptor activity|bone mineralization|male genitalia development|circadian regulation of gene expression|negative regulation of toll-like receptor signaling pathway|intestinal stem cell homeostasis|innate immune response|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|bone remodeling|digestive tract development|canonical Wnt signaling pathway involved in metanephric kidney development|cell differentiation involved in metanephros development|metanephric glomerulus development|metanephric nephron tubule morphogenesis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt signaling pathway|negative regulation of cold-induced thermogenesis|epithelial cell proliferation involved in renal tubule morphogenesis" hsa04310 Wnt signaling pathway LGR5 30.06820696 19.76786377 40.36855015 2.042130127 1.030074799 0.159028594 1 0.230193008 0.462217857 8549 leucine rich repeat containing G protein-coupled receptor 5 "GO:0001942,GO:0004888,GO:0004930,GO:0005515,GO:0005654,GO:0005794,GO:0005886,GO:0005887,GO:0007186,GO:0007189,GO:0007190,GO:0008528,GO:0009755,GO:0009994,GO:0016500,GO:0032588,GO:0042127,GO:0048839,GO:0090263,GO:2001013" hair follicle development|transmembrane signaling receptor activity|G protein-coupled receptor activity|protein binding|nucleoplasm|Golgi apparatus|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|G protein-coupled peptide receptor activity|hormone-mediated signaling pathway|oocyte differentiation|protein-hormone receptor activity|trans-Golgi network membrane|regulation of cell population proliferation|inner ear development|positive regulation of canonical Wnt signaling pathway|epithelial cell proliferation involved in renal tubule morphogenesis hsa04310 Wnt signaling pathway LGSN 3.923881751 2.080827765 5.766935736 2.771462315 1.470647391 0.503574097 1 0.011738896 0.031989496 51557 "lengsin, lens protein with glutamine synthetase domain" "GO:0004356,GO:0005737,GO:0005886,GO:0006542,GO:0016020,GO:0019740" glutamate-ammonia ligase activity|cytoplasm|plasma membrane|glutamine biosynthetic process|membrane|nitrogen utilization LHFPL2 2206.23888 2520.922838 1891.554921 0.750342253 -0.414379294 0.079718432 1 17.52468654 12.92947349 10184 LHFPL tetraspan subfamily member 2 "GO:0002576,GO:0003674,GO:0005515,GO:0005575,GO:0005886,GO:0007338,GO:0008150,GO:0016020,GO:0016021,GO:0031092,GO:0046545,GO:0046546,GO:1905516" platelet degranulation|molecular_function|protein binding|cellular_component|plasma membrane|single fertilization|biological_process|membrane|integral component of membrane|platelet alpha granule membrane|development of primary female sexual characteristics|development of primary male sexual characteristics|positive regulation of fertilization LHFPL6 677.5615729 629.450399 725.6727468 1.152867244 0.205226392 0.427091518 1 15.75638411 17.86105213 10186 LHFPL tetraspan subfamily member 6 "GO:0016020,GO:0016021" membrane|integral component of membrane LHPP 51.47594948 64.50566072 38.44623824 0.596013401 -0.746583325 0.209432065 1 0.472099363 0.276669075 64077 phospholysine phosphohistidine inorganic pyrophosphate phosphatase "GO:0000287,GO:0004427,GO:0005515,GO:0005634,GO:0005829,GO:0006470,GO:0006796,GO:0009168,GO:0016311,GO:0016607,GO:0016791,GO:0042803,GO:0101006" magnesium ion binding|inorganic diphosphatase activity|protein binding|nucleus|cytosol|protein dephosphorylation|phosphate-containing compound metabolic process|purine ribonucleoside monophosphate biosynthetic process|dephosphorylation|nuclear speck|phosphatase activity|protein homodimerization activity|protein histidine phosphatase activity hsa00190 Oxidative phosphorylation LHX1 427.5729343 450.4992112 404.6466575 0.898218349 -0.154861902 0.589984814 1 7.019653991 6.199673333 3975 LIM homeobox 1 "GO:0000785,GO:0000977,GO:0000981,GO:0000987,GO:0001655,GO:0001657,GO:0001658,GO:0001702,GO:0001705,GO:0001706,GO:0001822,GO:0003700,GO:0005515,GO:0005634,GO:0005667,GO:0006357,GO:0006366,GO:0007267,GO:0007389,GO:0007399,GO:0008045,GO:0009653,GO:0009791,GO:0009880,GO:0009887,GO:0009948,GO:0009952,GO:0009953,GO:0010468,GO:0010842,GO:0021517,GO:0021527,GO:0021537,GO:0021549,GO:0021702,GO:0021871,GO:0021937,GO:0030182,GO:0032525,GO:0032991,GO:0035502,GO:0035846,GO:0035847,GO:0035849,GO:0035852,GO:0040019,GO:0044344,GO:0045892,GO:0045893,GO:0046872,GO:0048382,GO:0048646,GO:0048703,GO:0048793,GO:0060059,GO:0060065,GO:0060066,GO:0060067,GO:0060068,GO:0060322,GO:0060429,GO:0061205,GO:0072049,GO:0072050,GO:0072077,GO:0072177,GO:0072178,GO:0072197,GO:0072224,GO:0072278,GO:0072283,GO:0072284,GO:0090009,GO:0090190,GO:0097379,GO:0097477,GO:1990837,GO:2000543,GO:2000744,GO:2000768" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|urogenital system development|ureteric bud development|branching involved in ureteric bud morphogenesis|gastrulation with mouth forming second|ectoderm formation|endoderm formation|kidney development|DNA-binding transcription factor activity|protein binding|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|cell-cell signaling|pattern specification process|nervous system development|motor neuron axon guidance|anatomical structure morphogenesis|post-embryonic development|embryonic pattern specification|animal organ morphogenesis|anterior/posterior axis specification|anterior/posterior pattern specification|dorsal/ventral pattern formation|regulation of gene expression|retina layer formation|ventral spinal cord development|spinal cord association neuron differentiation|telencephalon development|cerebellum development|cerebellar Purkinje cell differentiation|forebrain regionalization|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|neuron differentiation|somite rostral/caudal axis specification|protein-containing complex|metanephric part of ureteric bud development|oviduct epithelium development|uterine epithelium development|nephric duct elongation|horizontal cell localization|positive regulation of embryonic development|cellular response to fibroblast growth factor stimulus|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|mesendoderm development|anatomical structure formation involved in morphogenesis|embryonic viscerocranium morphogenesis|pronephros development|embryonic retina morphogenesis in camera-type eye|uterus development|oviduct development|cervix development|vagina development|head development|epithelium development|paramesonephric duct development|comma-shaped body morphogenesis|S-shaped body morphogenesis|renal vesicle morphogenesis|mesonephric duct development|nephric duct morphogenesis|ureter morphogenesis|metanephric glomerulus development|metanephric comma-shaped body morphogenesis|metanephric renal vesicle morphogenesis|metanephric S-shaped body morphogenesis|primitive streak formation|positive regulation of branching involved in ureteric bud morphogenesis|dorsal spinal cord interneuron posterior axon guidance|lateral motor column neuron migration|sequence-specific double-stranded DNA binding|positive regulation of gastrulation|positive regulation of anterior head development|positive regulation of nephron tubule epithelial cell differentiation" LHX4 15.20991861 20.80827765 9.61155956 0.461910386 -1.11431511 0.249863018 1 0.150637484 0.068416674 89884 LIM homeobox 4 "GO:0000785,GO:0000977,GO:0000981,GO:0001228,GO:0001890,GO:0005515,GO:0005634,GO:0006357,GO:0008045,GO:0008327,GO:0009887,GO:0021526,GO:0030182,GO:0043066,GO:0043565,GO:0045944,GO:0046872,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|placenta development|protein binding|nucleus|regulation of transcription by RNA polymerase II|motor neuron axon guidance|methyl-CpG binding|animal organ morphogenesis|medial motor column neuron differentiation|neuron differentiation|negative regulation of apoptotic process|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" LHX5 2.962725795 2.080827765 3.844623824 1.847641543 0.88568489 0.829811711 1 0.040543977 0.073657207 64211 LIM homeobox 5 "GO:0000785,GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0021527,GO:0021702,GO:0021766,GO:0021846,GO:0021879,GO:0021937,GO:0030182,GO:0045893,GO:0046872,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|spinal cord association neuron differentiation|cerebellar Purkinje cell differentiation|hippocampus development|cell proliferation in forebrain|forebrain neuron differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|neuron differentiation|positive regulation of transcription, DNA-templated|metal ion binding|sequence-specific double-stranded DNA binding" hsa04550 Signaling pathways regulating pluripotency of stem cells LHX6 10.85011826 7.282897178 14.41733934 1.979615939 0.985220564 0.397526524 1 0.076995808 0.14987155 26468 LIM homeobox 6 "GO:0000785,GO:0000977,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0021799,GO:0021800,GO:0021853,GO:0021884,GO:0030182,GO:0046872,GO:0048469,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration|cerebral cortex GABAergic interneuron migration|forebrain neuron development|neuron differentiation|metal ion binding|cell maturation|sequence-specific double-stranded DNA binding" LHX9 15.93330078 14.56579436 17.30080721 1.187769564 0.248254969 0.853385722 1 0.086612777 0.10115453 56956 LIM homeobox 9 "GO:0000785,GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0008283,GO:0008584,GO:0008585,GO:0030182,GO:0035262,GO:0045892,GO:0046872,GO:0097380,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|cell population proliferation|male gonad development|female gonad development|neuron differentiation|gonad morphogenesis|negative regulation of transcription, DNA-templated|metal ion binding|dorsal spinal cord interneuron anterior axon guidance|sequence-specific double-stranded DNA binding" LIAS 250.3943746 265.3055401 235.4832092 0.887592506 -0.172030608 0.614127234 1 3.744741884 3.268185461 11019 lipoic acid synthetase "GO:0001843,GO:0005739,GO:0005759,GO:0006954,GO:0006979,GO:0009107,GO:0009249,GO:0016992,GO:0032496,GO:0034641,GO:0046872,GO:0051539,GO:0102552,GO:0102553" "neural tube closure|mitochondrion|mitochondrial matrix|inflammatory response|response to oxidative stress|lipoate biosynthetic process|protein lipoylation|lipoate synthase activity|response to lipopolysaccharide|cellular nitrogen compound metabolic process|metal ion binding|4 iron, 4 sulfur cluster binding|lipoyl synthase activity (acting on glycine-cleavage complex H protein|lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)" hsa00785 Lipoic acid metabolism LIF 11596.83836 11999.09331 11194.58342 0.932952443 -0.100124552 0.694640031 1 151.9263479 139.3682296 3976 LIF interleukin 6 family cytokine "GO:0001974,GO:0005102,GO:0005125,GO:0005146,GO:0005515,GO:0005576,GO:0005615,GO:0005829,GO:0006955,GO:0007260,GO:0007275,GO:0007566,GO:0008083,GO:0008284,GO:0008285,GO:0019221,GO:0019827,GO:0033138,GO:0033141,GO:0033630,GO:0042531,GO:0043410,GO:0045595,GO:0045651,GO:0045835,GO:0045944,GO:0046697,GO:0046888,GO:0048286,GO:0048644,GO:0048666,GO:0048711,GO:0048861,GO:0048863,GO:0050731,GO:0060426,GO:0060463,GO:0060707,GO:0070373,GO:0072108,GO:0072307,GO:1900182,GO:1901676,GO:1903025" blood vessel remodeling|signaling receptor binding|cytokine activity|leukemia inhibitory factor receptor binding|protein binding|extracellular region|extracellular space|cytosol|immune response|tyrosine phosphorylation of STAT protein|multicellular organism development|embryo implantation|growth factor activity|positive regulation of cell population proliferation|negative regulation of cell population proliferation|cytokine-mediated signaling pathway|stem cell population maintenance|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of cell adhesion mediated by integrin|positive regulation of tyrosine phosphorylation of STAT protein|positive regulation of MAPK cascade|regulation of cell differentiation|positive regulation of macrophage differentiation|negative regulation of meiotic nuclear division|positive regulation of transcription by RNA polymerase II|decidualization|negative regulation of hormone secretion|lung alveolus development|muscle organ morphogenesis|neuron development|positive regulation of astrocyte differentiation|leukemia inhibitory factor signaling pathway|stem cell differentiation|positive regulation of peptidyl-tyrosine phosphorylation|lung vasculature development|lung lobe morphogenesis|trophoblast giant cell differentiation|negative regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|regulation of metanephric nephron tubule epithelial cell differentiation|positive regulation of protein localization to nucleus|positive regulation of histone H3-K27 acetylation|regulation of RNA polymerase II regulatory region sequence-specific DNA binding "hsa04060,hsa04550,hsa04630,hsa04668" Cytokine-cytokine receptor interaction|Signaling pathways regulating pluripotency of stem cells|JAK-STAT signaling pathway|TNF signaling pathway LIFR 464.8598718 445.2971418 484.4226018 1.087863713 0.121497827 0.667332328 1 2.102325728 2.24877329 3977 LIF receptor subunit alpha "GO:0001959,GO:0004896,GO:0004897,GO:0004923,GO:0004924,GO:0005127,GO:0005515,GO:0005886,GO:0005887,GO:0007166,GO:0008284,GO:0009897,GO:0019221,GO:0019838,GO:0019955,GO:0034097,GO:0038165,GO:0043235,GO:0048861,GO:0070062,GO:0070120" regulation of cytokine-mediated signaling pathway|cytokine receptor activity|ciliary neurotrophic factor receptor activity|leukemia inhibitory factor receptor activity|oncostatin-M receptor activity|ciliary neurotrophic factor receptor binding|protein binding|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|positive regulation of cell population proliferation|external side of plasma membrane|cytokine-mediated signaling pathway|growth factor binding|cytokine binding|response to cytokine|oncostatin-M-mediated signaling pathway|receptor complex|leukemia inhibitory factor signaling pathway|extracellular exosome|ciliary neurotrophic factor-mediated signaling pathway "hsa04060,hsa04550,hsa04630" Cytokine-cytokine receptor interaction|Signaling pathways regulating pluripotency of stem cells|JAK-STAT signaling pathway LIG1 837.3355297 774.0679287 900.6031308 1.163467827 0.218431317 0.38385259 1 13.21938646 15.12296182 3978 DNA ligase 1 "GO:0003677,GO:0003909,GO:0003910,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0006266,GO:0006273,GO:0006281,GO:0006283,GO:0006284,GO:0006297,GO:0006298,GO:0009653,GO:0033151,GO:0043231,GO:0046872,GO:0051301,GO:0071897,GO:1903461" "DNA binding|DNA ligase activity|DNA ligase (ATP) activity|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|DNA ligation|lagging strand elongation|DNA repair|transcription-coupled nucleotide-excision repair|base-excision repair|nucleotide-excision repair, DNA gap filling|mismatch repair|anatomical structure morphogenesis|V(D)J recombination|intracellular membrane-bounded organelle|metal ion binding|cell division|DNA biosynthetic process|Okazaki fragment processing involved in mitotic DNA replication" "hsa03030,hsa03410,hsa03420,hsa03430" DNA replication|Base excision repair|Nucleotide excision repair|Mismatch repair LIG3 549.3070034 580.5509465 518.0630603 0.892364509 -0.164294959 0.542353845 1 6.293507416 5.522124782 3980 DNA ligase 3 "GO:0000724,GO:0003677,GO:0003909,GO:0003910,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0006266,GO:0006273,GO:0006283,GO:0006288,GO:0006297,GO:0006302,GO:0007049,GO:0008270,GO:0033151,GO:0043504,GO:0051301,GO:0070421,GO:0071897,GO:0090298,GO:0097681" "double-strand break repair via homologous recombination|DNA binding|DNA ligase activity|DNA ligase (ATP) activity|protein binding|ATP binding|nucleoplasm|cytoplasm|mitochondrion|DNA ligation|lagging strand elongation|transcription-coupled nucleotide-excision repair|base-excision repair, DNA ligation|nucleotide-excision repair, DNA gap filling|double-strand break repair|cell cycle|zinc ion binding|V(D)J recombination|mitochondrial DNA repair|cell division|DNA ligase III-XRCC1 complex|DNA biosynthetic process|negative regulation of mitochondrial DNA replication|double-strand break repair via alternative nonhomologous end joining" hsa03410 Base excision repair LIG4 712.4110219 610.7229491 814.0990947 1.333008848 0.414686356 0.104672504 1 7.37902679 9.671710706 3981 DNA ligase 4 "GO:0000012,GO:0000781,GO:0000793,GO:0001701,GO:0002328,GO:0003677,GO:0003909,GO:0003910,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005958,GO:0006260,GO:0006266,GO:0006297,GO:0006302,GO:0006303,GO:0007049,GO:0007417,GO:0008022,GO:0008283,GO:0010165,GO:0010332,GO:0016874,GO:0032807,GO:0033077,GO:0033151,GO:0033152,GO:0033153,GO:0035019,GO:0036464,GO:0043524,GO:0045190,GO:0046872,GO:0048146,GO:0050769,GO:0051102,GO:0051103,GO:0051276,GO:0051301,GO:0051402,GO:0070419,GO:0071285,GO:0071479,GO:0071897,GO:0075713,GO:0097680,GO:2001252" "single strand break repair|chromosome, telomeric region|condensed chromosome|in utero embryonic development|pro-B cell differentiation|DNA binding|DNA ligase activity|DNA ligase (ATP) activity|protein binding|ATP binding|nucleus|nucleoplasm|DNA-dependent protein kinase-DNA ligase 4 complex|DNA replication|DNA ligation|nucleotide-excision repair, DNA gap filling|double-strand break repair|double-strand break repair via nonhomologous end joining|cell cycle|central nervous system development|protein C-terminus binding|cell population proliferation|response to X-ray|response to gamma radiation|ligase activity|DNA ligase IV complex|T cell differentiation in thymus|V(D)J recombination|immunoglobulin V(D)J recombination|T cell receptor V(D)J recombination|somatic stem cell population maintenance|cytoplasmic ribonucleoprotein granule|negative regulation of neuron apoptotic process|isotype switching|metal ion binding|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|chromosome organization|cell division|neuron apoptotic process|nonhomologous end joining complex|cellular response to lithium ion|cellular response to ionizing radiation|DNA biosynthetic process|establishment of integrated proviral latency|double-strand break repair via classical nonhomologous end joining|positive regulation of chromosome organization" hsa03450 Non-homologous end-joining LIMA1 6846.09776 6201.907154 7490.288365 1.207739519 0.272309333 0.264640091 1 74.57962736 88.56551758 51474 LIM domain and actin binding 1 "GO:0001725,GO:0001726,GO:0003785,GO:0005515,GO:0005829,GO:0005886,GO:0005925,GO:0008203,GO:0015629,GO:0016477,GO:0030299,GO:0030835,GO:0031526,GO:0031529,GO:0032154,GO:0042632,GO:0045296,GO:0046872,GO:0051015,GO:0051017" stress fiber|ruffle|actin monomer binding|protein binding|cytosol|plasma membrane|focal adhesion|cholesterol metabolic process|actin cytoskeleton|cell migration|intestinal cholesterol absorption|negative regulation of actin filament depolymerization|brush border membrane|ruffle organization|cleavage furrow|cholesterol homeostasis|cadherin binding|metal ion binding|actin filament binding|actin filament bundle assembly LIMCH1 2277.627961 2363.820341 2191.43558 0.927073662 -0.10924412 0.644925704 1 13.3579783 12.17660324 22998 LIM and calponin homology domains 1 "GO:0001725,GO:0001934,GO:0003779,GO:0005515,GO:0005737,GO:0016460,GO:0030336,GO:0031032,GO:0032034,GO:0046872,GO:0051496,GO:0051893,GO:0060327" stress fiber|positive regulation of protein phosphorylation|actin binding|protein binding|cytoplasm|myosin II complex|negative regulation of cell migration|actomyosin structure organization|myosin II head/neck binding|metal ion binding|positive regulation of stress fiber assembly|regulation of focal adhesion assembly|cytoplasmic actin-based contraction involved in cell motility LIMD1 1328.096308 1344.214736 1311.97788 0.976018075 -0.035020229 0.887194235 1 5.273321811 5.060731717 8994 LIM domain containing 1 "GO:0000932,GO:0001666,GO:0002076,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0005925,GO:0006355,GO:0007010,GO:0008360,GO:0016310,GO:0016442,GO:0016477,GO:0033962,GO:0035195,GO:0035331,GO:0045668,GO:0045892,GO:0046872,GO:0061418,GO:0090090,GO:2000637" "P-body|response to hypoxia|osteoblast development|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|plasma membrane|adherens junction|focal adhesion|regulation of transcription, DNA-templated|cytoskeleton organization|regulation of cell shape|phosphorylation|RISC complex|cell migration|P-body assembly|gene silencing by miRNA|negative regulation of hippo signaling|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|metal ion binding|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of canonical Wnt signaling pathway|positive regulation of gene silencing by miRNA" "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species LIMD2 567.975317 565.9851522 569.9654819 1.007032569 0.010110343 0.977114524 1 8.465691517 8.382568949 80774 LIM domain containing 2 "GO:0005515,GO:0005654,GO:0005829,GO:0046872" protein binding|nucleoplasm|cytosol|metal ion binding LIME1 122.1404195 115.485941 128.7948981 1.115243094 0.157358214 0.732714617 1 3.751230929 4.113528604 54923 Lck interacting transmembrane adaptor 1 "GO:0002250,GO:0005515,GO:0005615,GO:0006357,GO:0014066,GO:0016021,GO:0019815,GO:0019901,GO:0043122,GO:0043405,GO:0050852,GO:0050853,GO:0051279,GO:1901222" adaptive immune response|protein binding|extracellular space|regulation of transcription by RNA polymerase II|regulation of phosphatidylinositol 3-kinase signaling|integral component of membrane|B cell receptor complex|protein kinase binding|regulation of I-kappaB kinase/NF-kappaB signaling|regulation of MAP kinase activity|T cell receptor signaling pathway|B cell receptor signaling pathway|regulation of release of sequestered calcium ion into cytosol|regulation of NIK/NF-kappaB signaling LIMK1 2712.024564 2577.105187 2846.943942 1.104706147 0.143662662 0.544077516 1 40.00446985 43.45367066 3984 LIM domain kinase 1 "GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0006468,GO:0007165,GO:0007266,GO:0007399,GO:0016607,GO:0030027,GO:0030036,GO:0031072,GO:0032233,GO:0038096,GO:0043005,GO:0045773,GO:0046872,GO:0051444,GO:0051496,GO:0106310,GO:0106311" protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|cytoskeleton|protein phosphorylation|signal transduction|Rho protein signal transduction|nervous system development|nuclear speck|lamellipodium|actin cytoskeleton organization|heat shock protein binding|positive regulation of actin filament bundle assembly|Fc-gamma receptor signaling pathway involved in phagocytosis|neuron projection|positive regulation of axon extension|metal ion binding|negative regulation of ubiquitin-protein transferase activity|positive regulation of stress fiber assembly|protein serine kinase activity|protein threonine kinase activity "hsa04360,hsa04666,hsa04810,hsa05135,hsa05170" Axon guidance|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Yersinia infection|Human immunodeficiency virus 1 infection LIMK2 634.9832472 647.137435 622.8290595 0.962437074 -0.055235877 0.837468357 1 7.043959926 6.665924636 3985 LIM domain kinase 2 "GO:0001934,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005801,GO:0005813,GO:0006468,GO:0007283,GO:0016310,GO:0030036,GO:0030953,GO:0046872,GO:0051650,GO:0060322,GO:0061303,GO:0072686,GO:0106310,GO:0106311,GO:1900182,GO:1902018" positive regulation of protein phosphorylation|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cis-Golgi network|centrosome|protein phosphorylation|spermatogenesis|phosphorylation|actin cytoskeleton organization|astral microtubule organization|metal ion binding|establishment of vesicle localization|head development|cornea development in camera-type eye|mitotic spindle|protein serine kinase activity|protein threonine kinase activity|positive regulation of protein localization to nucleus|negative regulation of cilium assembly "hsa04360,hsa04666,hsa04810,hsa05170" Axon guidance|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Human immunodeficiency virus 1 infection LIMS1 1666.320753 1896.674508 1435.966998 0.757097221 -0.401449523 0.091151658 1 16.23709216 12.08734968 3987 LIM zinc finger domain containing 1 "GO:0001837,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0005925,GO:0007569,GO:0008270,GO:0010628,GO:0010811,GO:0019901,GO:0032991,GO:0033209,GO:0034329,GO:0043547,GO:0044877,GO:0045184,GO:0045216,GO:0045892,GO:0048471,GO:0050678,GO:0051894,GO:0071560,GO:0098609,GO:1900026,GO:1901224,GO:2001046" "epithelial to mesenchymal transition|protein binding|cytoplasm|cytosol|plasma membrane|cell-cell junction|focal adhesion|cell aging|zinc ion binding|positive regulation of gene expression|positive regulation of cell-substrate adhesion|protein kinase binding|protein-containing complex|tumor necrosis factor-mediated signaling pathway|cell junction assembly|positive regulation of GTPase activity|protein-containing complex binding|establishment of protein localization|cell-cell junction organization|negative regulation of transcription, DNA-templated|perinuclear region of cytoplasm|regulation of epithelial cell proliferation|positive regulation of focal adhesion assembly|cellular response to transforming growth factor beta stimulus|cell-cell adhesion|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of NIK/NF-kappaB signaling|positive regulation of integrin-mediated signaling pathway" LIMS2 110.1806903 79.07145508 141.2899255 1.786863861 0.837429721 0.064629476 1 0.885788881 1.556298392 55679 LIM zinc finger domain containing 2 "GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0005925,GO:0034329,GO:0043066,GO:0045216,GO:0046872,GO:0098609,GO:1900026,GO:2000178,GO:2000346,GO:2001046" nucleus|cytoplasm|cytosol|plasma membrane|cell-cell junction|focal adhesion|cell junction assembly|negative regulation of apoptotic process|cell-cell junction organization|metal ion binding|cell-cell adhesion|positive regulation of substrate adhesion-dependent cell spreading|negative regulation of neural precursor cell proliferation|negative regulation of hepatocyte proliferation|positive regulation of integrin-mediated signaling pathway LIMS4 49.95998804 49.93986637 49.98010971 1.000805836 0.001162108 1 1 0.641289433 0.631066449 100288695 LIM zinc finger domain containing 4 "GO:0005515,GO:0046872" protein binding|metal ion binding LIN37 135.6312015 129.0113214 142.2510815 1.102624792 0.140941945 0.751548393 1 6.082241266 6.594206987 55957 lin-37 DREAM MuvB core complex component "GO:0000122,GO:0005515,GO:0005654,GO:0017053,GO:0031523,GO:0051726" negative regulation of transcription by RNA polymerase II|protein binding|nucleoplasm|transcription repressor complex|Myb complex|regulation of cell cycle hsa04218 Cellular senescence LIN52 352.9550144 371.4277561 334.4822727 0.900531172 -0.151151878 0.619320112 1 2.112138166 1.870218091 91750 lin-52 DREAM MuvB core complex component "GO:0005515,GO:0005654,GO:0006351,GO:0051726,GO:0070176" "protein binding|nucleoplasm|transcription, DNA-templated|regulation of cell cycle|DRM complex" hsa04218 Cellular senescence LIN54 587.5148535 675.2286098 499.8010971 0.74019538 -0.434021965 0.10000519 1 5.729047677 4.169653677 132660 lin-54 DREAM MuvB core complex component "GO:0001067,GO:0003680,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0007049,GO:0016584,GO:0046872,GO:0051726" "regulatory region nucleic acid binding|minor groove of adenine-thymine-rich DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|cell cycle|nucleosome positioning|metal ion binding|regulation of cell cycle" hsa04218 Cellular senescence LIN7A 127.0204268 130.0517353 123.9891183 0.953383036 -0.068872139 0.891102042 1 1.17817384 1.104454869 8825 "lin-7 homolog A, crumbs cell polarity complex component" "GO:0005515,GO:0005886,GO:0005911,GO:0005923,GO:0006887,GO:0007269,GO:0015031,GO:0016323,GO:0045199,GO:0045202,GO:0048489,GO:0048839,GO:0065003,GO:0070062,GO:0097016,GO:0097025,GO:0098793,GO:0098839,GO:1903361" protein binding|plasma membrane|cell-cell junction|bicellular tight junction|exocytosis|neurotransmitter secretion|protein transport|basolateral plasma membrane|maintenance of epithelial cell apical/basal polarity|synapse|synaptic vesicle transport|inner ear development|protein-containing complex assembly|extracellular exosome|L27 domain binding|MPP7-DLG1-LIN7 complex|presynapse|postsynaptic density membrane|protein localization to basolateral plasma membrane LIN7B 41.43350174 40.57614142 42.29086206 1.042259332 0.05971429 0.967723263 1 2.628002539 2.693225709 64130 "lin-7 homolog B, crumbs cell polarity complex component" "GO:0005515,GO:0005886,GO:0005911,GO:0005923,GO:0006887,GO:0007269,GO:0015031,GO:0016323,GO:0019904,GO:0030165,GO:0045199,GO:0045202,GO:0097016,GO:0097025,GO:0098793,GO:0098839,GO:1903361" protein binding|plasma membrane|cell-cell junction|bicellular tight junction|exocytosis|neurotransmitter secretion|protein transport|basolateral plasma membrane|protein domain specific binding|PDZ domain binding|maintenance of epithelial cell apical/basal polarity|synapse|L27 domain binding|MPP7-DLG1-LIN7 complex|presynapse|postsynaptic density membrane|protein localization to basolateral plasma membrane LIN7C 396.603322 381.8318949 411.3747492 1.077371363 0.107515624 0.717169069 1 4.208522605 4.458269015 55327 "lin-7 homolog C, crumbs cell polarity complex component" "GO:0002011,GO:0005515,GO:0005737,GO:0005886,GO:0005911,GO:0005923,GO:0006887,GO:0007269,GO:0008092,GO:0015031,GO:0016323,GO:0019904,GO:0030165,GO:0045199,GO:0045202,GO:0097016,GO:0097025,GO:0098793,GO:0098839,GO:0098978,GO:1903361" morphogenesis of an epithelial sheet|protein binding|cytoplasm|plasma membrane|cell-cell junction|bicellular tight junction|exocytosis|neurotransmitter secretion|cytoskeletal protein binding|protein transport|basolateral plasma membrane|protein domain specific binding|PDZ domain binding|maintenance of epithelial cell apical/basal polarity|synapse|L27 domain binding|MPP7-DLG1-LIN7 complex|presynapse|postsynaptic density membrane|glutamatergic synapse|protein localization to basolateral plasma membrane LIN9 299.4825255 292.356301 306.60875 1.048750271 0.068671184 0.837159595 1 3.06834188 3.164076772 286826 lin-9 DREAM MuvB core complex component "GO:0000003,GO:0003677,GO:0005515,GO:0005654,GO:0006351,GO:0006357,GO:0007049,GO:0017053,GO:0051726,GO:0071897" "reproduction|DNA binding|protein binding|nucleoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|cell cycle|transcription repressor complex|regulation of cell cycle|DNA biosynthetic process" hsa04218 Cellular senescence other LINC02210-CRHR1 152.4067713 140.4558742 164.3576685 1.170172978 0.226721808 0.58257928 1 2.705114347 3.112482163 104909134 LINC02210-CRHR1 readthrough LINS1 260.095253 242.4164347 277.7740713 1.145854949 0.196424428 0.558115513 1 2.221761905 2.503216076 55180 lines homolog 1 GO:0050890 cognition LIPA 4082.986662 3885.945852 4280.027472 1.10141202 0.139354259 0.559001787 1 65.07241545 70.47221441 3988 "lipase A, lysosomal acid type" "GO:0000902,GO:0001650,GO:0004771,GO:0005654,GO:0005764,GO:0005829,GO:0006954,GO:0008283,GO:0016042,GO:0016125,GO:0016298,GO:0030324,GO:0034383,GO:0043202,GO:0043231,GO:0048771,GO:0048873" cell morphogenesis|fibrillar center|sterol esterase activity|nucleoplasm|lysosome|cytosol|inflammatory response|cell population proliferation|lipid catabolic process|sterol metabolic process|lipase activity|lung development|low-density lipoprotein particle clearance|lysosomal lumen|intracellular membrane-bounded organelle|tissue remodeling|homeostasis of number of cells within a tissue "hsa00100,hsa04142,hsa04979" Steroid biosynthesis|Lysosome|Cholesterol metabolism LIPC 8.006279355 8.323311061 7.689247648 0.923820772 -0.11431511 1 1 0.089900792 0.081662453 3990 "lipase C, hepatic type" "GO:0004465,GO:0004620,GO:0004622,GO:0004806,GO:0005576,GO:0005615,GO:0005788,GO:0006633,GO:0008201,GO:0008970,GO:0016042,GO:0016298,GO:0019433,GO:0030169,GO:0034185,GO:0034364,GO:0034372,GO:0034373,GO:0034374,GO:0034375,GO:0034382,GO:0034638,GO:0042632,GO:0043691,GO:0051004,GO:0052739,GO:0052740,GO:0070328,GO:0102545" lipoprotein lipase activity|phospholipase activity|lysophospholipase activity|triglyceride lipase activity|extracellular region|extracellular space|endoplasmic reticulum lumen|fatty acid biosynthetic process|heparin binding|phospholipase A1 activity|lipid catabolic process|lipase activity|triglyceride catabolic process|low-density lipoprotein particle binding|apolipoprotein binding|high-density lipoprotein particle|very-low-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|high-density lipoprotein particle remodeling|chylomicron remnant clearance|phosphatidylcholine catabolic process|cholesterol homeostasis|reverse cholesterol transport|regulation of lipoprotein lipase activity|phosphatidylserine 1-acylhydrolase activity|1-acyl-2-lysophosphatidylserine acylhydrolase activity|triglyceride homeostasis|phosphatidyl phospholipase B activity "hsa00561,hsa04979" Glycerolipid metabolism|Cholesterol metabolism LIPE 87.8262687 97.79890497 77.85363244 0.796058325 -0.329053959 0.510774375 1 1.037025196 0.811718371 3991 "lipase E, hormone sensitive type" "GO:0004771,GO:0004806,GO:0005515,GO:0005811,GO:0005829,GO:0005901,GO:0006468,GO:0008203,GO:0016020,GO:0016042,GO:0019433,GO:0033878,GO:0042572,GO:0046340,GO:0046485,GO:0047372,GO:0050253,GO:0102258,GO:0102259" "sterol esterase activity|triglyceride lipase activity|protein binding|lipid droplet|cytosol|caveola|protein phosphorylation|cholesterol metabolic process|membrane|lipid catabolic process|triglyceride catabolic process|hormone-sensitive lipase activity|retinol metabolic process|diacylglycerol catabolic process|ether lipid metabolic process|acylglycerol lipase activity|retinyl-palmitate esterase activity|1,3-diacylglycerol acylhydrolase activity|1,2-diacylglycerol acylhydrolase activity" "hsa04024,hsa04152,hsa04371,hsa04714,hsa04910,hsa04923,hsa04925" cAMP signaling pathway|AMPK signaling pathway|Apelin signaling pathway|Thermogenesis|Insulin signaling pathway|Regulation of lipolysis in adipocytes|Aldosterone synthesis and secretion LIPG 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.014239608 0 9388 "lipase G, endothelial type" "GO:0004465,GO:0004620,GO:0004806,GO:0005576,GO:0005615,GO:0005769,GO:0005794,GO:0006629,GO:0006633,GO:0007584,GO:0008201,GO:0008283,GO:0008970,GO:0009395,GO:0009986,GO:0010983,GO:0016042,GO:0016298,GO:0019433,GO:0032376,GO:0034375,GO:0042632,GO:0043691,GO:0050746,GO:0052739,GO:0052740,GO:0055091" lipoprotein lipase activity|phospholipase activity|triglyceride lipase activity|extracellular region|extracellular space|early endosome|Golgi apparatus|lipid metabolic process|fatty acid biosynthetic process|response to nutrient|heparin binding|cell population proliferation|phospholipase A1 activity|phospholipid catabolic process|cell surface|positive regulation of high-density lipoprotein particle clearance|lipid catabolic process|lipase activity|triglyceride catabolic process|positive regulation of cholesterol transport|high-density lipoprotein particle remodeling|cholesterol homeostasis|reverse cholesterol transport|regulation of lipoprotein metabolic process|phosphatidylserine 1-acylhydrolase activity|1-acyl-2-lysophosphatidylserine acylhydrolase activity|phospholipid homeostasis "hsa00561,hsa04979" Glycerolipid metabolism|Cholesterol metabolism LIPH 29.66185649 34.33365813 24.99005486 0.72785879 -0.458269511 0.55017537 1 0.444415288 0.318058715 200879 lipase H "GO:0004465,GO:0004620,GO:0005615,GO:0005886,GO:0006633,GO:0006654,GO:0008201,GO:0016042,GO:0016298,GO:0019433" lipoprotein lipase activity|phospholipase activity|extracellular space|plasma membrane|fatty acid biosynthetic process|phosphatidic acid biosynthetic process|heparin binding|lipid catabolic process|lipase activity|triglyceride catabolic process LIPT1 87.86589767 98.83931885 76.89247648 0.777954334 -0.362242623 0.46704333 1 2.731679331 2.08956074 51601 lipoyltransferase 1 "GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0006464,GO:0006629,GO:0009249,GO:0016746,GO:0016979,GO:0017118,GO:0018215,GO:0034641" "protein binding|cytoplasm|mitochondrion|mitochondrial matrix|cellular protein modification process|lipid metabolic process|protein lipoylation|transferase activity, transferring acyl groups|lipoate-protein ligase activity|lipoyltransferase activity|protein phosphopantetheinylation|cellular nitrogen compound metabolic process" hsa00785 Lipoic acid metabolism LIPT2 26.06003687 28.09117483 24.0288989 0.855389603 -0.225346422 0.811740419 1 0.632296234 0.531809072 387787 lipoyl(octanoyl) transferase 2 "GO:0005739,GO:0005759,GO:0009249,GO:0016874,GO:0018215,GO:0033819,GO:0034641,GO:0102555,GO:2000376" mitochondrion|mitochondrial matrix|protein lipoylation|ligase activity|protein phosphopantetheinylation|lipoyl(octanoyl) transferase activity|cellular nitrogen compound metabolic process|octanoyl transferase activity (acting on glycine-cleavage complex H protein)|positive regulation of oxygen metabolic process hsa00785 Lipoic acid metabolism LITAF 1831.912564 1815.522225 1848.302903 1.018055785 0.025816616 0.915606758 1 23.54010796 23.56411887 9516 lipopolysaccharide induced TNF factor "GO:0000139,GO:0000978,GO:0001228,GO:0001817,GO:0005515,GO:0005654,GO:0005765,GO:0005794,GO:0005886,GO:0006357,GO:0007568,GO:0008270,GO:0009898,GO:0043123,GO:0043231,GO:0045944,GO:0050699,GO:0071222,GO:0098559,GO:0098560,GO:0098574,GO:1901223" "Golgi membrane|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|regulation of cytokine production|protein binding|nucleoplasm|lysosomal membrane|Golgi apparatus|plasma membrane|regulation of transcription by RNA polymerase II|aging|zinc ion binding|cytoplasmic side of plasma membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|WW domain binding|cellular response to lipopolysaccharide|cytoplasmic side of early endosome membrane|cytoplasmic side of late endosome membrane|cytoplasmic side of lysosomal membrane|negative regulation of NIK/NF-kappaB signaling" hsa04142 Lysosome LIX1 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.01474767 0.040188663 167410 limb and CNS expressed 1 "GO:0005515,GO:0005737,GO:0097352" protein binding|cytoplasm|autophagosome maturation LIX1L 1676.637416 1637.611451 1715.663381 1.047662057 0.067173423 0.779362993 1 21.89834962 22.55816554 128077 limb and CNS expressed 1 like "GO:0003674,GO:0005575,GO:0005737,GO:0008150,GO:0097352" molecular_function|cellular_component|cytoplasm|biological_process|autophagosome maturation LLGL1 1624.72935 1751.016564 1498.442135 0.855755546 -0.224729359 0.34498773 1 21.66169119 18.22691889 3996 LLGL scribble cell polarity complex component 1 "GO:0000137,GO:0005096,GO:0005198,GO:0005515,GO:0005737,GO:0005856,GO:0005886,GO:0006887,GO:0006893,GO:0007409,GO:0008593,GO:0019901,GO:0030424,GO:0030864,GO:0030866,GO:0031901,GO:0032588,GO:0032878,GO:0043547,GO:0045159,GO:0050708,GO:0051294,GO:0065003" Golgi cis cisterna|GTPase activator activity|structural molecule activity|protein binding|cytoplasm|cytoskeleton|plasma membrane|exocytosis|Golgi to plasma membrane transport|axonogenesis|regulation of Notch signaling pathway|protein kinase binding|axon|cortical actin cytoskeleton|cortical actin cytoskeleton organization|early endosome membrane|trans-Golgi network membrane|regulation of establishment or maintenance of cell polarity|positive regulation of GTPase activity|myosin II binding|regulation of protein secretion|establishment of spindle orientation|protein-containing complex assembly "hsa04390,hsa04530,hsa05165" Hippo signaling pathway|Tight junction|Human papillomavirus infection LLGL2 189.8717319 190.3957405 189.3477233 0.994495585 -0.007963129 0.999192034 1 1.621361216 1.585454628 3993 LLGL scribble cell polarity complex component 2 "GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0006887,GO:0008593,GO:0015820,GO:0030165,GO:0030864,GO:0030866,GO:0032878,GO:0043231,GO:0043547,GO:0045159,GO:0050708,GO:0051294,GO:0051301" GTPase activator activity|protein binding|cytoplasm|cytosol|plasma membrane|exocytosis|regulation of Notch signaling pathway|leucine transport|PDZ domain binding|cortical actin cytoskeleton|cortical actin cytoskeleton organization|regulation of establishment or maintenance of cell polarity|intracellular membrane-bounded organelle|positive regulation of GTPase activity|myosin II binding|regulation of protein secretion|establishment of spindle orientation|cell division "hsa04390,hsa04530,hsa05165" Hippo signaling pathway|Tight junction|Human papillomavirus infection LLPH 806.4697131 745.9767539 866.9626723 1.162184569 0.216839205 0.389499294 1 5.15157975 5.886900708 84298 "LLP homolog, long-term synaptic facilitation factor" "GO:0001099,GO:0003723,GO:0005515,GO:0005694,GO:0005730,GO:0060999,GO:0097484" basal RNA polymerase II transcription machinery binding|RNA binding|protein binding|chromosome|nucleolus|positive regulation of dendritic spine development|dendrite extension LMAN1 8591.488739 8458.564866 8724.412613 1.031429415 0.044645095 0.857551231 1 93.57754161 94.90352047 3998 "lectin, mannose binding 1" "GO:0000139,GO:0005515,GO:0005537,GO:0005783,GO:0005789,GO:0005793,GO:0005829,GO:0006457,GO:0006888,GO:0007029,GO:0007030,GO:0007596,GO:0010638,GO:0012507,GO:0016020,GO:0016021,GO:0018279,GO:0030017,GO:0030134,GO:0032527,GO:0033116,GO:0034498,GO:0046872,GO:0048208,GO:0051082,GO:0062023,GO:0070062,GO:1903215" Golgi membrane|protein binding|mannose binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|cytosol|protein folding|endoplasmic reticulum to Golgi vesicle-mediated transport|endoplasmic reticulum organization|Golgi organization|blood coagulation|positive regulation of organelle organization|ER to Golgi transport vesicle membrane|membrane|integral component of membrane|protein N-linked glycosylation via asparagine|sarcomere|COPII-coated ER to Golgi transport vesicle|protein exit from endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment membrane|early endosome to Golgi transport|metal ion binding|COPII vesicle coating|unfolded protein binding|collagen-containing extracellular matrix|extracellular exosome|negative regulation of protein targeting to mitochondrion hsa04141 Protein processing in endoplasmic reticulum LMAN2 2634.681693 2502.195388 2767.167997 1.105896051 0.145215785 0.539660321 1 82.89110429 90.13498922 10960 "lectin, mannose binding 2" "GO:0000139,GO:0005515,GO:0005537,GO:0005615,GO:0005789,GO:0005793,GO:0005794,GO:0005887,GO:0006888,GO:0006890,GO:0007029,GO:0007030,GO:0009986,GO:0015031,GO:0030134,GO:0030246,GO:0031072,GO:0033116,GO:0046872,GO:0050766,GO:0070062" "Golgi membrane|protein binding|mannose binding|extracellular space|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|integral component of plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|endoplasmic reticulum organization|Golgi organization|cell surface|protein transport|COPII-coated ER to Golgi transport vesicle|carbohydrate binding|heat shock protein binding|endoplasmic reticulum-Golgi intermediate compartment membrane|metal ion binding|positive regulation of phagocytosis|extracellular exosome" hsa04141 Protein processing in endoplasmic reticulum LMAN2L 479.5099545 464.0245917 494.9953173 1.066743716 0.093213612 0.741466112 1 9.803697393 10.28303158 81562 "lectin, mannose binding 2 like" "GO:0000139,GO:0005515,GO:0005537,GO:0005789,GO:0005793,GO:0005794,GO:0006457,GO:0006888,GO:0007029,GO:0007030,GO:0015031,GO:0016021,GO:0030134,GO:0046872" Golgi membrane|protein binding|mannose binding|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|protein folding|endoplasmic reticulum to Golgi vesicle-mediated transport|endoplasmic reticulum organization|Golgi organization|protein transport|integral component of membrane|COPII-coated ER to Golgi transport vesicle|metal ion binding LMBR1 1490.82293 1515.883027 1465.762833 0.966936635 -0.048506745 0.841497949 1 9.78351567 9.301738765 64327 limb development membrane protein 1 "GO:0004888,GO:0005515,GO:0005887,GO:0007165" transmembrane signaling receptor activity|protein binding|integral component of plasma membrane|signal transduction LMBR1L 791.819016 828.1694506 755.4685814 0.912214983 -0.132554228 0.601433137 1 11.22058428 10.06430644 55716 limb development membrane protein 1 like "GO:0004888,GO:0005515,GO:0005789,GO:0005886,GO:0005887,GO:0006898,GO:0007165,GO:0016055,GO:0030217,GO:0042098,GO:0060218,GO:0070231,GO:0090090" transmembrane signaling receptor activity|protein binding|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|receptor-mediated endocytosis|signal transduction|Wnt signaling pathway|T cell differentiation|T cell proliferation|hematopoietic stem cell differentiation|T cell apoptotic process|negative regulation of canonical Wnt signaling pathway LMBRD1 583.2550471 512.9240441 653.5860501 1.274235547 0.34963199 0.186286566 1 6.492840019 8.134963284 55788 LMBR1 domain containing 1 "GO:0005515,GO:0005765,GO:0005789,GO:0009235,GO:0015420,GO:0015889,GO:0016020,GO:0016021,GO:0016032,GO:0031419,GO:0043231,GO:0061462" protein binding|lysosomal membrane|endoplasmic reticulum membrane|cobalamin metabolic process|ATPase-coupled vitamin B12 transmembrane transporter activity|cobalamin transport|membrane|integral component of membrane|viral process|cobalamin binding|intracellular membrane-bounded organelle|protein localization to lysosome hsa04977 Vitamin digestion and absorption LMBRD2 647.1908111 664.824471 629.5571512 0.946952434 -0.078636134 0.766578015 1 4.052131124 3.772965498 92255 LMBR1 domain containing 2 "GO:0005886,GO:0016020,GO:0016021,GO:0071875" plasma membrane|membrane|integral component of membrane|adrenergic receptor signaling pathway LMCD1 99.63754292 105.0818021 94.19328369 0.896380551 -0.157816749 0.752905468 1 0.579042091 0.510356602 29995 LIM and cysteine rich domains 1 "GO:0000122,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008270,GO:0010611,GO:0044267,GO:0070886" negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|zinc ion binding|regulation of cardiac muscle hypertrophy|cellular protein metabolic process|positive regulation of calcineurin-NFAT signaling cascade LMF2 1461.895131 1349.416806 1574.373456 1.166706572 0.222441767 0.352332172 1 22.94230481 26.31902935 91289 lipase maturation factor 2 "GO:0005515,GO:0005789,GO:0016020,GO:0016021,GO:0051604" protein binding|endoplasmic reticulum membrane|membrane|integral component of membrane|protein maturation LMLN 214.8812941 241.3760208 188.3865674 0.780469273 -0.357586261 0.31378788 1 1.800642242 1.38182938 89782 leishmanolysin like peptidase "GO:0004222,GO:0005737,GO:0005811,GO:0005829,GO:0005925,GO:0006508,GO:0007049,GO:0007155,GO:0008233,GO:0016020,GO:0046872,GO:0051301" metalloendopeptidase activity|cytoplasm|lipid droplet|cytosol|focal adhesion|proteolysis|cell cycle|cell adhesion|peptidase activity|membrane|metal ion binding|cell division LMNA 7398.575196 7660.567418 7136.582973 0.931599787 -0.102217786 0.677138176 1 120.3858668 110.2747452 4000 lamin A/C "GO:0005515,GO:0005634,GO:0005635,GO:0005652,GO:0005654,GO:0005829,GO:0005882,GO:0007084,GO:0008285,GO:0016363,GO:0016604,GO:0016607,GO:0030334,GO:0030951,GO:0031965,GO:0034504,GO:0035861,GO:0036498,GO:0071456,GO:0090343,GO:1903243,GO:1990683" protein binding|nucleus|nuclear envelope|nuclear lamina|nucleoplasm|cytosol|intermediate filament|mitotic nuclear envelope reassembly|negative regulation of cell population proliferation|nuclear matrix|nuclear body|nuclear speck|regulation of cell migration|establishment or maintenance of microtubule cytoskeleton polarity|nuclear membrane|protein localization to nucleus|site of double-strand break|IRE1-mediated unfolded protein response|cellular response to hypoxia|positive regulation of cell aging|negative regulation of cardiac muscle hypertrophy in response to stress|DNA double-strand break attachment to nuclear envelope "hsa04210,hsa05410,hsa05412,hsa05414" Apoptosis|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy LMNB1 1301.852603 1374.386739 1229.318468 0.894448726 -0.160929312 0.504723337 1 32.35487174 28.45550589 4001 lamin B1 "GO:0005198,GO:0005515,GO:0005634,GO:0005635,GO:0005637,GO:0005638,GO:0005654,GO:0016020,GO:0016363,GO:0031965,GO:0035722,GO:0043274,GO:1990837" structural molecule activity|protein binding|nucleus|nuclear envelope|nuclear inner membrane|lamin filament|nucleoplasm|membrane|nuclear matrix|nuclear membrane|interleukin-12-mediated signaling pathway|phospholipase binding|sequence-specific double-stranded DNA binding hsa04210 Apoptosis other LMNB2 5416.186274 5187.503619 5644.86893 1.088166745 0.121899645 0.613140299 1 59.74267024 63.92213295 84823 lamin B2 "GO:0003674,GO:0005515,GO:0005637,GO:0005882,GO:0008150,GO:0031965,GO:0042802" molecular_function|protein binding|nuclear inner membrane|intermediate filament|biological_process|nuclear membrane|identical protein binding hsa04210 Apoptosis LMNTD2 84.34836638 82.19269673 86.50403604 1.052454044 0.073757238 0.906438861 1 1.850051945 1.914512658 256329 lamin tail domain containing 2 GO:0005515 protein binding LMO2 4.444088692 3.121241648 5.766935736 1.847641543 0.88568489 0.705170935 1 0.054382935 0.098798771 4005 LIM domain only 2 "GO:0001102,GO:0001221,GO:0003713,GO:0005515,GO:0005654,GO:0005667,GO:0007275,GO:0043425,GO:0045944,GO:0046872,GO:0097067,GO:1902036" RNA polymerase II activating transcription factor binding|transcription coregulator binding|transcription coactivator activity|protein binding|nucleoplasm|transcription regulator complex|multicellular organism development|bHLH transcription factor binding|positive regulation of transcription by RNA polymerase II|metal ion binding|cellular response to thyroid hormone stimulus|regulation of hematopoietic stem cell differentiation hsa05202 Transcriptional misregulation in cancer other LMO4 887.8446785 951.9787026 823.7106543 0.865261641 -0.208791649 0.402098965 1 10.03265278 8.535607013 8543 LIM domain only 4 "GO:0001843,GO:0003281,GO:0005515,GO:0005667,GO:0008134,GO:0021514,GO:0021522,GO:0021527,GO:0030334,GO:0031252,GO:0031333,GO:0033674,GO:0042659,GO:0045944,GO:0046872,GO:0048538,GO:0050865,GO:0090575" neural tube closure|ventricular septum development|protein binding|transcription regulator complex|transcription factor binding|ventral spinal cord interneuron differentiation|spinal cord motor neuron differentiation|spinal cord association neuron differentiation|regulation of cell migration|cell leading edge|negative regulation of protein-containing complex assembly|positive regulation of kinase activity|regulation of cell fate specification|positive regulation of transcription by RNA polymerase II|metal ion binding|thymus development|regulation of cell activation|RNA polymerase II transcription regulator complex LMO7 1990.181235 1819.683881 2160.678589 1.187392278 0.247796636 0.295201532 1 10.64254074 12.42540978 4008 LIM domain 7 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005635,GO:0005737,GO:0005829,GO:0005925,GO:0009986,GO:0016324,GO:0016567,GO:0023051,GO:0030155,GO:0043687,GO:0045944,GO:0046872" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|nuclear envelope|cytoplasm|cytosol|focal adhesion|cell surface|apical plasma membrane|protein ubiquitination|regulation of signaling|regulation of cell adhesion|post-translational protein modification|positive regulation of transcription by RNA polymerase II|metal ion binding hsa04520 Adherens junction LMOD1 7.486072413 7.282897178 7.689247648 1.055795168 0.078329968 1 1 0.098975003 0.102748709 25802 leiomodin 1 "GO:0003779,GO:0005523,GO:0005829,GO:0005856,GO:0005865,GO:0005884,GO:0006936,GO:0007015,GO:0016020,GO:0030016,GO:0030017,GO:0030239,GO:0030838,GO:0045010,GO:0051694" actin binding|tropomyosin binding|cytosol|cytoskeleton|striated muscle thin filament|actin filament|muscle contraction|actin filament organization|membrane|myofibril|sarcomere|myofibril assembly|positive regulation of actin filament polymerization|actin nucleation|pointed-end actin filament capping LMTK2 1096.190995 1211.041759 981.3402311 0.810327326 -0.303423302 0.213474937 1 7.203641652 5.739628241 22853 lemur tyrosine kinase 2 "GO:0001881,GO:0004674,GO:0004714,GO:0004864,GO:0005515,GO:0005524,GO:0005769,GO:0005794,GO:0005829,GO:0005887,GO:0006468,GO:0007169,GO:0007275,GO:0007409,GO:0016021,GO:0018105,GO:0018107,GO:0018108,GO:0030426,GO:0032456,GO:0032515,GO:0033572,GO:0033674,GO:0043025,GO:0043235,GO:0045022,GO:0046777,GO:0048471,GO:0055037,GO:0070853,GO:0106310,GO:0106311" receptor recycling|protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity|protein phosphatase inhibitor activity|protein binding|ATP binding|early endosome|Golgi apparatus|cytosol|integral component of plasma membrane|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axonogenesis|integral component of membrane|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|growth cone|endocytic recycling|negative regulation of phosphoprotein phosphatase activity|transferrin transport|positive regulation of kinase activity|neuronal cell body|receptor complex|early endosome to late endosome transport|protein autophosphorylation|perinuclear region of cytoplasm|recycling endosome|myosin VI binding|protein serine kinase activity|protein threonine kinase activity LMTK3 41.83482179 38.49531366 45.17432993 1.173502061 0.230820376 0.747484045 1 0.370299953 0.42727619 114783 lemur tyrosine kinase 3 "GO:0000139,GO:0003674,GO:0004672,GO:0005515,GO:0005524,GO:0005575,GO:0006468,GO:0010923,GO:0016021,GO:0030424,GO:0030425,GO:0046872,GO:0106310,GO:0106311" Golgi membrane|molecular_function|protein kinase activity|protein binding|ATP binding|cellular_component|protein phosphorylation|negative regulation of phosphatase activity|integral component of membrane|axon|dendrite|metal ion binding|protein serine kinase activity|protein threonine kinase activity LNP1 49.11771897 53.06110801 45.17432993 0.851364241 -0.2321516 0.724918323 1 1.51919196 1.271742651 348801 leukemia NUP98 fusion partner 1 LNPEP 1868.212579 1973.665135 1762.760023 0.893140377 -0.16304115 0.491944628 1 7.763756234 6.818090994 4012 leucyl and cystinyl aminopeptidase "GO:0000209,GO:0002480,GO:0004177,GO:0005515,GO:0005576,GO:0005737,GO:0005765,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0007165,GO:0007267,GO:0007565,GO:0008217,GO:0008237,GO:0008270,GO:0016020,GO:0031905,GO:0042277,GO:0043171,GO:0070006,GO:0120163" "protein polyubiquitination|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|aminopeptidase activity|protein binding|extracellular region|cytoplasm|lysosomal membrane|cytosol|plasma membrane|integral component of plasma membrane|proteolysis|signal transduction|cell-cell signaling|female pregnancy|regulation of blood pressure|metallopeptidase activity|zinc ion binding|membrane|early endosome lumen|peptide binding|peptide catabolic process|metalloaminopeptidase activity|negative regulation of cold-induced thermogenesis" hsa04614 Renin-angiotensin system LNPK 1364.714584 1308.840664 1420.588503 1.085379253 0.118199237 0.623868221 1 8.220597942 8.773161063 80856 "lunapark, ER junction formation factor" "GO:0005654,GO:0005783,GO:0005789,GO:0007029,GO:0007596,GO:0016021,GO:0030176,GO:0032330,GO:0035115,GO:0042733,GO:0042802,GO:0046872,GO:0060173,GO:0071782,GO:0071786,GO:0071788,GO:0098826,GO:1903373" nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum organization|blood coagulation|integral component of membrane|integral component of endoplasmic reticulum membrane|regulation of chondrocyte differentiation|embryonic forelimb morphogenesis|embryonic digit morphogenesis|identical protein binding|metal ion binding|limb development|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network maintenance|endoplasmic reticulum tubular network membrane|positive regulation of endoplasmic reticulum tubular network organization LNX1 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.02565059 0.031066691 84708 ligand of numb-protein X 1 "GO:0004842,GO:0005515,GO:0005737,GO:0006511,GO:0016567,GO:0030165,GO:0042802,GO:0046872" ubiquitin-protein transferase activity|protein binding|cytoplasm|ubiquitin-dependent protein catabolic process|protein ubiquitination|PDZ domain binding|identical protein binding|metal ion binding LNX2 381.5814874 391.1956199 371.967355 0.950847443 -0.072714205 0.811869536 1 4.333206983 4.0512725 222484 ligand of numb-protein X 2 "GO:0005515,GO:0030165,GO:0042802,GO:0046872" protein binding|PDZ domain binding|identical protein binding|metal ion binding LOC100133315 57.84235009 67.62690237 48.0577978 0.710631363 -0.492826733 0.392787253 1 0.679684272 0.474922527 100133315 XRCC1 N-terminal domain containing 1-like "GO:0000012,GO:0003684,GO:0005694,GO:0005730" single strand break repair|damaged DNA binding|chromosome|nucleolus LOC100421372 509.0378328 532.6919079 485.3837578 0.91119041 -0.134175532 0.626220672 1 6.1005983 5.465787563 100421372 zinc finger and SCAN domain containing 29 LOC100505841 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.031638163 0.114955607 100505841 zinc finger protein 474-like LOC100509620 3.443303773 2.080827765 4.80577978 2.309551929 1.207612985 0.648665767 1 0.030391339 0.069015835 100509620 putative aquaporin-7-like protein 3 "hsa03320,hsa04923" PPAR signaling pathway|Regulation of lipolysis in adipocytes LOC101928764 6.485287494 6.242483296 6.728091692 1.0777909 0.108077311 1 1 0.05797944 0.061444032 101928764 coiled-coil domain-containing protein 144B LOC101928841 15.97292975 15.60620824 16.33965125 1.046996875 0.066257136 1 1 0.085274358 0.087787973 101928841 collagen alpha-1(II) chain-like LOC101929937 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.108025247 0.130834688 101929937 LOC101930420 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.028028762 0.076380776 101930420 DNA primase large subunit-like LOC102723728 3.081612685 5.202069413 0.961155956 0.184764154 -2.436243205 0.338470402 1 0.177850662 0.032310552 102723728 LOC102723996 13.64929778 17.687036 9.61155956 0.543423983 -0.879849856 0.395956707 1 0.172249015 0.092037906 102723996 ICOS ligand "hsa04514,hsa04672" Cell adhesion molecules|Intestinal immune network for IgA production LOC102724159 294.2653648 319.407062 269.1236677 0.842572691 -0.247126938 0.438086078 1 5.346978624 4.429829442 102724159 periodic tryptophan protein 2 homolog "GO:0000028,GO:0000462,GO:0003723,GO:0005654,GO:0006364,GO:0032040,GO:0034388" "ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleoplasm|rRNA processing|small-subunit processome|Pwp2p-containing subcomplex of 90S preribosome" LOC102724200 31.8269726 28.09117483 35.56277037 1.265976613 0.340250754 0.659887996 1 0.465726739 0.579733016 102724200 LOC102724250 273.1645932 307.9625093 238.3666771 0.774011998 -0.369572165 0.256621191 1 2.98716705 2.273413222 102724250 LOC102724474 15.89367182 13.52538047 18.26196316 1.350199589 0.433172685 0.689082402 1 0.555249767 0.737152827 102724474 LOC102724770 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.049709021 0.13546134 102724770 protein DGCR6 "GO:0003674,GO:0005515,GO:0005634,GO:0007155,GO:0009887,GO:0031012" molecular_function|protein binding|nucleus|cell adhesion|animal organ morphogenesis|extracellular matrix LOC102724813 25.460572 24.96993318 25.95121081 1.039298368 0.055609892 1 1 0.859741575 0.878576035 102724813 LOC102724877 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.058798069 0.017803308 102724877 LOC102725191 3.844623824 0 7.689247648 Inf Inf 0.057816489 1 0 0.201646266 102725191 uncharacterized LOC102725191 LOC105369669 4.003139677 4.161655531 3.844623824 0.923820772 -0.11431511 1 1 0.233789376 0.212365357 105369669 LOC105371932 6.564545421 8.323311061 4.80577978 0.577387982 -0.792387015 0.636893371 1 0.379333744 0.215357696 105371932 LOC105372704 18.73751072 12.48496659 24.99005486 2.001611672 1.001162108 0.261248142 1 0.398028507 0.783366835 105372704 LOC105373989 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.042909565 0.116932239 105373989 LOC105376714 24.61830293 28.09117483 21.14543103 0.752742851 -0.409770993 0.63048508 1 1.529769767 1.132254073 105376714 LOC105377805 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.009087558 0.024764373 105377805 LOC105378148 2.561405743 4.161655531 0.961155956 0.230955193 -2.11431511 0.482263142 1 0.113200768 0.025706816 105378148 LOC105379752 14.53119581 15.60620824 13.45618338 0.86223272 -0.213850783 0.895568055 1 0.101943042 0.086427762 105379752 LOC107984449 451.9188649 458.8225222 445.0152076 0.969907069 -0.044081572 0.882732802 1 10.07675503 9.609969384 107984449 LOC107984638 7.045123399 8.323311061 5.766935736 0.692865579 -0.529352609 0.780164403 1 0.320721887 0.218498653 107984638 LOC107984817 2.080827765 4.161655531 0 0 #NAME? 0.234194363 1 0.084480756 0 107984817 LOC107985021 9.086322201 11.44455271 6.728091692 0.587885946 -0.766391806 0.566347083 1 0.061625945 0.035622783 107985021 LOC107985678 14.49156685 14.56579436 14.41733934 0.98980797 -0.014779436 1 1 0.349527731 0.340176073 107985678 LOC107985805 2.923096831 1.040413883 4.80577978 4.619103859 2.207612985 0.416510993 1 0.046078819 0.209281213 107985805 LOC107986762 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.076340481 0.069344783 107986762 LOC107987158 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.008236905 0.022446272 107987158 LOC107987254 1.922311912 0 3.844623824 Inf Inf 0.288176591 1 0 0.092842655 107987254 LOC107987269 35.63196746 27.05076095 44.21317398 1.634452135 0.708807128 0.303960202 1 0.828255533 1.331090952 107987269 LOC107987372 7.44644345 6.242483296 8.650403604 1.385731158 0.470647391 0.809847313 1 0.404799344 0.551556441 107987372 LOC107987373 599.6689259 527.4898385 671.8480132 1.273670058 0.348991598 0.184718578 1 21.73834996 27.22417288 107987373 LOC112267904 6.083967443 8.323311061 3.844623824 0.461910386 -1.11431511 0.492415049 1 0.066937886 0.030401912 112267904 LOC112268052 5.603389465 8.323311061 2.883467868 0.346432789 -1.529352609 0.352439314 1 0.350591802 0.119424086 112268052 LOC112268131 4.122026567 7.282897178 0.961155956 0.131974396 -2.921670032 0.166282975 1 0.196598299 0.025511772 112268131 LOC112268444 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.041313227 0.062545601 112268444 LOC112694756 57.52531838 59.30359131 55.74704545 0.940028154 -0.089224129 0.906464604 1 1.362429476 1.259290916 112694756 uncharaterized LOC112694756 LOC114841035 13.08946188 15.60620824 10.57271552 0.677468566 -0.561774087 0.621805553 1 0.503247523 0.335229303 114841035 Uncharacterized protein LOC114841035 LOC389831 1517.620826 1601.196965 1434.044686 0.895607922 -0.159060806 0.505745808 1 32.98067895 29.04348297 389831 uncharacterized LOC389831 LOC389895 39.91250988 38.49531366 41.32970611 1.073629546 0.102496279 0.914792032 1 1.664849383 1.757521241 389895 chromosome 16 open reading frame 72-like LOC400499 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.011795421 0.003571503 400499 putative uncharacterized protein LOC400499 LOC441155 21.05611227 22.88910542 19.22311912 0.839837065 -0.251818634 0.811354362 1 0.282439188 0.233233629 441155 zinc finger CCCH-type domain-containing-like LOC728392 127.6299525 108.2030438 147.0568613 1.359082482 0.442633015 0.305891905 1 3.849731719 5.144550781 728392 uncharacterized LOC728392 LOC730098 46.75948846 41.61655531 51.90242162 1.247158042 0.318644297 0.624427077 1 1.122850894 1.376939185 730098 uncharacterized LOC730098 LONP1 1621.722579 1659.460143 1583.985015 0.954518264 -0.067155291 0.779720026 1 25.7748364 24.19086171 9361 "lon peptidase 1, mitochondrial" "GO:0000002,GO:0001018,GO:0001666,GO:0003697,GO:0003727,GO:0004176,GO:0004252,GO:0005515,GO:0005524,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0006515,GO:0007005,GO:0007568,GO:0009725,GO:0010044,GO:0016020,GO:0016887,GO:0032042,GO:0034599,GO:0042645,GO:0042802,GO:0043531,GO:0043565,GO:0051131,GO:0051603,GO:0051880,GO:0070182,GO:0070407" mitochondrial genome maintenance|mitochondrial promoter sequence-specific DNA binding|response to hypoxia|single-stranded DNA binding|single-stranded RNA binding|ATP-dependent peptidase activity|serine-type endopeptidase activity|protein binding|ATP binding|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|protein quality control for misfolded or incompletely synthesized proteins|mitochondrion organization|aging|response to hormone|response to aluminum ion|membrane|ATPase activity|mitochondrial DNA metabolic process|cellular response to oxidative stress|mitochondrial nucleoid|identical protein binding|ADP binding|sequence-specific DNA binding|chaperone-mediated protein complex assembly|proteolysis involved in cellular protein catabolic process|G-quadruplex DNA binding|DNA polymerase binding|oxidation-dependent protein catabolic process LONP2 2085.403643 2048.574935 2122.232351 1.035955441 0.050961951 0.831158527 1 11.0959788 11.30258737 83752 "lon peptidase 2, peroxisomal" "GO:0002020,GO:0004176,GO:0004252,GO:0005515,GO:0005524,GO:0005634,GO:0005777,GO:0005782,GO:0005829,GO:0006515,GO:0006625,GO:0007031,GO:0008233,GO:0014070,GO:0016020,GO:0016485,GO:0016558,GO:0019899,GO:0031998" protease binding|ATP-dependent peptidase activity|serine-type endopeptidase activity|protein binding|ATP binding|nucleus|peroxisome|peroxisomal matrix|cytosol|protein quality control for misfolded or incompletely synthesized proteins|protein targeting to peroxisome|peroxisome organization|peptidase activity|response to organic cyclic compound|membrane|protein processing|protein import into peroxisome matrix|enzyme binding|regulation of fatty acid beta-oxidation LONRF1 253.748974 189.3553266 318.1426214 1.680135579 0.748577657 0.024919371 0.86041596 2.429217731 4.013118185 91694 LON peptidase N-terminal domain and ring finger 1 "GO:0000209,GO:0005515,GO:0005829,GO:0046872" protein polyubiquitination|protein binding|cytosol|metal ion binding LONRF2 15.20991861 20.80827765 9.61155956 0.461910386 -1.11431511 0.249863018 1 0.073358405 0.033317989 164832 LON peptidase N-terminal domain and ring finger 2 "GO:0005515,GO:0046872" protein binding|metal ion binding LONRF3 146.7832602 182.0724295 111.4940909 0.612361197 -0.707545227 0.083328845 1 2.40457088 1.44782618 79836 LON peptidase N-terminal domain and ring finger 3 "GO:0005515,GO:0046872" protein binding|metal ion binding LOX 4096.53658 3951.491926 4241.581234 1.073412603 0.102204732 0.668536358 1 39.80442838 42.01160371 4015 lysyl oxidase "GO:0001649,GO:0001932,GO:0004720,GO:0005507,GO:0005515,GO:0005518,GO:0005576,GO:0005581,GO:0005615,GO:0005634,GO:0006464,GO:0007507,GO:0010468,GO:0016202,GO:0017015,GO:0018057,GO:0018215,GO:0030198,GO:0030199,GO:0030282,GO:0030324,GO:0031012,GO:0035791,GO:0035905,GO:0035906,GO:0042060,GO:0042493,GO:0042981,GO:0043491,GO:0045652,GO:0046716,GO:0048251,GO:0048514,GO:0048545,GO:0048747,GO:0060326,GO:0061448,GO:0071897,GO:1900120,GO:1903010,GO:1990869,GO:2000586" osteoblast differentiation|regulation of protein phosphorylation|protein-lysine 6-oxidase activity|copper ion binding|protein binding|collagen binding|extracellular region|collagen trimer|extracellular space|nucleus|cellular protein modification process|heart development|regulation of gene expression|regulation of striated muscle tissue development|regulation of transforming growth factor beta receptor signaling pathway|peptidyl-lysine oxidation|protein phosphopantetheinylation|extracellular matrix organization|collagen fibril organization|bone mineralization|lung development|extracellular matrix|platelet-derived growth factor receptor-beta signaling pathway|ascending aorta development|descending aorta development|wound healing|response to drug|regulation of apoptotic process|protein kinase B signaling|regulation of megakaryocyte differentiation|muscle cell cellular homeostasis|elastic fiber assembly|blood vessel morphogenesis|response to steroid hormone|muscle fiber development|cell chemotaxis|connective tissue development|DNA biosynthetic process|regulation of receptor binding|regulation of bone development|cellular response to chemokine|regulation of platelet-derived growth factor receptor-beta signaling pathway LOXL1 56.00935694 44.73779695 67.28091692 1.50389428 0.588703152 0.311186013 1 0.802545882 1.186747585 4016 lysyl oxidase like 1 "GO:0001669,GO:0004720,GO:0005507,GO:0005515,GO:0005576,GO:0005604,GO:0005615,GO:0018057,GO:0018215,GO:0018277,GO:0030198,GO:0030199,GO:0032496,GO:0035904,GO:0055114,GO:0062023" acrosomal vesicle|protein-lysine 6-oxidase activity|copper ion binding|protein binding|extracellular region|basement membrane|extracellular space|peptidyl-lysine oxidation|protein phosphopantetheinylation|protein deamination|extracellular matrix organization|collagen fibril organization|response to lipopolysaccharide|aorta development|oxidation-reduction process|collagen-containing extracellular matrix LOXL2 6725.399919 7575.25348 5875.546359 0.77562373 -0.366571152 0.132897555 1 108.6475021 82.85944355 4017 lysyl oxidase like 2 "GO:0000122,GO:0000785,GO:0001666,GO:0001837,GO:0001935,GO:0002040,GO:0004720,GO:0005044,GO:0005507,GO:0005509,GO:0005515,GO:0005604,GO:0005615,GO:0005634,GO:0005654,GO:0005783,GO:0006464,GO:0006897,GO:0007155,GO:0007568,GO:0009055,GO:0010718,GO:0016020,GO:0018057,GO:0018215,GO:0022900,GO:0030199,GO:0032332,GO:0043542,GO:0045892,GO:0046688,GO:0062023,GO:0070492,GO:0070828,GO:1902455" "negative regulation of transcription by RNA polymerase II|chromatin|response to hypoxia|epithelial to mesenchymal transition|endothelial cell proliferation|sprouting angiogenesis|protein-lysine 6-oxidase activity|scavenger receptor activity|copper ion binding|calcium ion binding|protein binding|basement membrane|extracellular space|nucleus|nucleoplasm|endoplasmic reticulum|cellular protein modification process|endocytosis|cell adhesion|aging|electron transfer activity|positive regulation of epithelial to mesenchymal transition|membrane|peptidyl-lysine oxidation|protein phosphopantetheinylation|electron transport chain|collagen fibril organization|positive regulation of chondrocyte differentiation|endothelial cell migration|negative regulation of transcription, DNA-templated|response to copper ion|collagen-containing extracellular matrix|oligosaccharide binding|heterochromatin organization|negative regulation of stem cell population maintenance" LOXL3 38.47077595 38.49531366 38.44623824 0.998725159 -0.001840381 1 1 0.52840127 0.518896835 84695 lysyl oxidase like 3 "GO:0001837,GO:0001968,GO:0004720,GO:0005044,GO:0005507,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0006897,GO:0006954,GO:0016020,GO:0018057,GO:0018215,GO:0021510,GO:0030199,GO:0030324,GO:0045892,GO:0060021,GO:0061053,GO:1905590,GO:2000329,GO:2001046" "epithelial to mesenchymal transition|fibronectin binding|protein-lysine 6-oxidase activity|scavenger receptor activity|copper ion binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|endocytosis|inflammatory response|membrane|peptidyl-lysine oxidation|protein phosphopantetheinylation|spinal cord development|collagen fibril organization|lung development|negative regulation of transcription, DNA-templated|roof of mouth development|somite development|fibronectin fibril organization|negative regulation of T-helper 17 cell lineage commitment|positive regulation of integrin-mediated signaling pathway" LOXL4 169.6377671 214.3252598 124.9502743 0.582993691 -0.778447824 0.044283582 1 2.57499892 1.47608744 84171 lysyl oxidase like 4 "GO:0004720,GO:0005044,GO:0005507,GO:0005515,GO:0005615,GO:0006897,GO:0016020,GO:0018057,GO:0018215,GO:0030199,GO:0043235,GO:0070062" protein-lysine 6-oxidase activity|scavenger receptor activity|copper ion binding|protein binding|extracellular space|endocytosis|membrane|peptidyl-lysine oxidation|protein phosphopantetheinylation|collagen fibril organization|receptor complex|extracellular exosome LPAR1 969.1070161 940.5341499 997.6798823 1.060758806 0.085096656 0.733081466 1 7.592584927 7.919130194 1902 lysophosphatidic acid receptor 1 "GO:0000187,GO:0001965,GO:0004930,GO:0005515,GO:0005737,GO:0005768,GO:0005886,GO:0005887,GO:0007186,GO:0007189,GO:0007193,GO:0007202,GO:0007204,GO:0008360,GO:0009986,GO:0010977,GO:0014003,GO:0019222,GO:0021549,GO:0021554,GO:0022008,GO:0022038,GO:0030139,GO:0030165,GO:0032060,GO:0035025,GO:0035727,GO:0042552,GO:0043025,GO:0043065,GO:0043123,GO:0043197,GO:0043198,GO:0043410,GO:0043951,GO:0051482,GO:0051496,GO:0060326,GO:0060999,GO:0070915,GO:0071453,GO:0071673,GO:1904566" activation of MAPK activity|G-protein alpha-subunit binding|G protein-coupled receptor activity|protein binding|cytoplasm|endosome|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|activation of phospholipase C activity|positive regulation of cytosolic calcium ion concentration|regulation of cell shape|cell surface|negative regulation of neuron projection development|oligodendrocyte development|regulation of metabolic process|cerebellum development|optic nerve development|neurogenesis|corpus callosum development|endocytic vesicle|PDZ domain binding|bleb assembly|positive regulation of Rho protein signal transduction|lysophosphatidic acid binding|myelination|neuronal cell body|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|dendritic spine|dendritic shaft|positive regulation of MAPK cascade|negative regulation of cAMP-mediated signaling|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|positive regulation of stress fiber assembly|cell chemotaxis|positive regulation of dendritic spine development|lysophosphatidic acid receptor activity|cellular response to oxygen levels|positive regulation of smooth muscle cell chemotaxis|cellular response to 1-oleoyl-sn-glycerol 3-phosphate "hsa04015,hsa04072,hsa04080,hsa04151,hsa04540,hsa04810,hsa05130,hsa05200" Rap1 signaling pathway|Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Gap junction|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Pathways in cancer LPAR2 151.0392649 155.0216685 147.0568613 0.948621329 -0.076095788 0.866522256 1 3.507088398 3.271227711 9170 lysophosphatidic acid receptor 2 "GO:0004930,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007189,GO:0007202,GO:0007204,GO:0008289,GO:0009986,GO:0019222,GO:0030139,GO:0070915" G protein-coupled receptor activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of phospholipase C activity|positive regulation of cytosolic calcium ion concentration|lipid binding|cell surface|regulation of metabolic process|endocytic vesicle|lysophosphatidic acid receptor activity "hsa04015,hsa04072,hsa04080,hsa04151,hsa04810,hsa05130,hsa05200" Rap1 signaling pathway|Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Pathways in cancer LPAR3 170.9907966 136.2942186 205.6873746 1.509142329 0.593728875 0.124332715 1 1.699876595 2.52242797 23566 lysophosphatidic acid receptor 3 "GO:0000187,GO:0001965,GO:0004930,GO:0005515,GO:0005543,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007187,GO:0007189,GO:0007204,GO:0007268,GO:0008289,GO:0019222,GO:0030424,GO:0032060,GO:0045202,GO:0048672,GO:0051482,GO:0051928,GO:0070915" "activation of MAPK activity|G-protein alpha-subunit binding|G protein-coupled receptor activity|protein binding|phospholipid binding|cytoplasm|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|chemical synaptic transmission|lipid binding|regulation of metabolic process|axon|bleb assembly|synapse|positive regulation of collateral sprouting|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|positive regulation of calcium ion transport|lysophosphatidic acid receptor activity" "hsa04015,hsa04072,hsa04080,hsa04151,hsa05200" Rap1 signaling pathway|Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Pathways in cancer LPAR4 55.64766585 47.8590386 63.4362931 1.325481977 0.406517053 0.492939401 1 0.445983749 0.581251436 2846 lysophosphatidic acid receptor 4 "GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0016604,GO:0035025,GO:0035727,GO:0043231,GO:0051482,GO:0070915" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|nuclear body|positive regulation of Rho protein signal transduction|lysophosphatidic acid binding|intracellular membrane-bounded organelle|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|lysophosphatidic acid receptor activity "hsa04015,hsa04072,hsa04080,hsa04151,hsa04810,hsa05130,hsa05200" Rap1 signaling pathway|Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Pathways in cancer LPAR5 62.24680981 69.70773014 54.78588949 0.785937074 -0.347514286 0.542924213 1 1.353774905 1.046177593 57121 lysophosphatidic acid receptor 5 "GO:0003674,GO:0004930,GO:0005575,GO:0005886,GO:0007186,GO:0008150,GO:0016021,GO:0032793,GO:0048266" molecular_function|G protein-coupled receptor activity|cellular_component|plasma membrane|G protein-coupled receptor signaling pathway|biological_process|integral component of membrane|positive regulation of CREB transcription factor activity|behavioral response to pain "hsa04015,hsa04072,hsa04151,hsa04810,hsa05130,hsa05200" Rap1 signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Pathways in cancer LPAR6 30.57835307 45.77821084 15.3784953 0.335934826 -1.573746729 0.031116257 0.895820653 0.627400867 0.207238921 10161 lysophosphatidic acid receptor 6 "GO:0001835,GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0007186,GO:0035025,GO:0051482,GO:0070915" blastocyst hatching|G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|positive regulation of Rho protein signal transduction|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|lysophosphatidic acid receptor activity "hsa04072,hsa04080,hsa04151,hsa05200" Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Pathways in cancer LPCAT1 2192.675713 2190.071223 2195.280203 1.002378453 0.003427307 0.990635909 1 24.59080076 24.23681634 79888 lysophosphatidylcholine acyltransferase 1 "GO:0000139,GO:0003841,GO:0005509,GO:0005783,GO:0005789,GO:0005794,GO:0005811,GO:0005886,GO:0006654,GO:0006656,GO:0008654,GO:0016020,GO:0016021,GO:0035577,GO:0036148,GO:0036151,GO:0043129,GO:0043312,GO:0045732,GO:0047159,GO:0047184,GO:0047191,GO:0047192,GO:0050200,GO:0060041,GO:2001246" Golgi membrane|1-acylglycerol-3-phosphate O-acyltransferase activity|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|lipid droplet|plasma membrane|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phospholipid biosynthetic process|membrane|integral component of membrane|azurophil granule membrane|phosphatidylglycerol acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|surfactant homeostasis|neutrophil degranulation|positive regulation of protein catabolic process|1-alkenylglycerophosphocholine O-acyltransferase activity|1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|plasmalogen synthase activity|retina development in camera-type eye|negative regulation of phosphatidylcholine biosynthetic process "hsa00564,hsa00565" Glycerophospholipid metabolism|Ether lipid metabolism LPCAT3 656.4161419 629.450399 683.3818847 1.085680279 0.118599308 0.650470409 1 15.03025097 16.04498664 10162 lysophosphatidylcholine acyltransferase 3 "GO:0005789,GO:0006656,GO:0016020,GO:0016021,GO:0016746,GO:0030258,GO:0034378,GO:0034379,GO:0036150,GO:0036151,GO:0036152,GO:0036335,GO:0045540,GO:0045797,GO:0047184,GO:0050728,GO:0071617,GO:0090158,GO:0106262,GO:0106263,GO:1901310,GO:1903573,GO:1905885" "endoplasmic reticulum membrane|phosphatidylcholine biosynthetic process|membrane|integral component of membrane|transferase activity, transferring acyl groups|lipid modification|chylomicron assembly|very-low-density lipoprotein particle assembly|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|intestinal stem cell homeostasis|regulation of cholesterol biosynthetic process|positive regulation of intestinal cholesterol absorption|1-acylglycerophosphocholine O-acyltransferase activity|negative regulation of inflammatory response|lysophospholipid acyltransferase activity|endoplasmic reticulum membrane organization|1-acylglycerophosphoethanolamine O-acyltransferase activity|1-acylglycerophosphoserine O-acyltransferase activity|positive regulation of sterol regulatory element binding protein cleavage|negative regulation of response to endoplasmic reticulum stress|positive regulation of triglyceride transport" "hsa00564,hsa04216" Glycerophospholipid metabolism|Ferroptosis LPCAT4 1088.74075 1015.443949 1162.037551 1.14436405 0.194546082 0.426290971 1 23.56190316 26.51219904 254531 lysophosphatidylcholine acyltransferase 4 "GO:0005783,GO:0005789,GO:0006644,GO:0006654,GO:0016020,GO:0016021,GO:0036148,GO:0036150,GO:0036151,GO:0036152,GO:0047166,GO:0047184,GO:0047192,GO:0071617,GO:0106262,GO:0106263" endoplasmic reticulum|endoplasmic reticulum membrane|phospholipid metabolic process|phosphatidic acid biosynthetic process|membrane|integral component of membrane|phosphatidylglycerol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|1-alkenylglycerophosphoethanolamine O-acyltransferase activity|1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|lysophospholipid acyltransferase activity|1-acylglycerophosphoethanolamine O-acyltransferase activity|1-acylglycerophosphoserine O-acyltransferase activity "hsa00564,hsa00565" Glycerophospholipid metabolism|Ether lipid metabolism LPGAT1 2353.859993 2611.438845 2096.28114 0.80273032 -0.317012704 0.179867491 1 14.25756435 11.25346297 9926 lysophosphatidylglycerol acyltransferase 1 "GO:0003846,GO:0005737,GO:0005783,GO:0005789,GO:0008654,GO:0012505,GO:0016020,GO:0016021,GO:0016746,GO:0019432,GO:0036148,GO:0036149,GO:0045723,GO:0071617" "2-acylglycerol O-acyltransferase activity|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|phospholipid biosynthetic process|endomembrane system|membrane|integral component of membrane|transferase activity, transferring acyl groups|triglyceride biosynthetic process|phosphatidylglycerol acyl-chain remodeling|phosphatidylinositol acyl-chain remodeling|positive regulation of fatty acid biosynthetic process|lysophospholipid acyltransferase activity" hsa00564 Glycerophospholipid metabolism LPIN1 746.6792846 841.6948311 651.6637382 0.774228039 -0.369169539 0.145774369 1 6.539482627 4.978327509 23175 lipin 1 "GO:0003713,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005741,GO:0005789,GO:0005829,GO:0006642,GO:0006646,GO:0006656,GO:0007077,GO:0008195,GO:0009062,GO:0016311,GO:0019432,GO:0031100,GO:0031965,GO:0032869,GO:0044255,GO:0045944,GO:0120162" transcription coactivator activity|protein binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|mitochondrial outer membrane|endoplasmic reticulum membrane|cytosol|triglyceride mobilization|phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process|mitotic nuclear envelope disassembly|phosphatidate phosphatase activity|fatty acid catabolic process|dephosphorylation|triglyceride biosynthetic process|animal organ regeneration|nuclear membrane|cellular response to insulin stimulus|cellular lipid metabolic process|positive regulation of transcription by RNA polymerase II|positive regulation of cold-induced thermogenesis "hsa00561,hsa00564,hsa04150" Glycerolipid metabolism|Glycerophospholipid metabolism|mTOR signaling pathway LPIN2 2205.511696 2337.809994 2073.213397 0.886818605 -0.173289058 0.463988782 1 18.54684446 16.17245696 9663 lipin 2 "GO:0003713,GO:0005634,GO:0005789,GO:0005829,GO:0006629,GO:0006646,GO:0006656,GO:0008195,GO:0009062,GO:0016311,GO:0019432,GO:0032869,GO:0044255,GO:0045944" transcription coactivator activity|nucleus|endoplasmic reticulum membrane|cytosol|lipid metabolic process|phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidate phosphatase activity|fatty acid catabolic process|dephosphorylation|triglyceride biosynthetic process|cellular response to insulin stimulus|cellular lipid metabolic process|positive regulation of transcription by RNA polymerase II "hsa00561,hsa00564,hsa04150" Glycerolipid metabolism|Glycerophospholipid metabolism|mTOR signaling pathway LPIN3 999.0311841 1019.605605 978.4567632 0.959642394 -0.059431203 0.812495952 1 10.65905528 10.05771484 64900 lipin 3 "GO:0003713,GO:0005634,GO:0005789,GO:0006646,GO:0006656,GO:0008195,GO:0009062,GO:0016311,GO:0019432,GO:0032869,GO:0044255,GO:0045944" transcription coactivator activity|nucleus|endoplasmic reticulum membrane|phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidate phosphatase activity|fatty acid catabolic process|dephosphorylation|triglyceride biosynthetic process|cellular response to insulin stimulus|cellular lipid metabolic process|positive regulation of transcription by RNA polymerase II "hsa00561,hsa00564,hsa04150" Glycerolipid metabolism|Glycerophospholipid metabolism|mTOR signaling pathway LPP 2306.105979 2354.456616 2257.755341 0.95892841 -0.060504981 0.799431436 1 5.308086444 5.004899386 4026 LIM domain containing preferred translocation partner in lipoma "GO:0001725,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0005925,GO:0008150,GO:0046872,GO:0098609" stress fiber|protein binding|nucleus|cytosol|plasma membrane|focal adhesion|biological_process|metal ion binding|cell-cell adhesion LPXN 118.4939405 120.6880104 116.2998707 0.963640633 -0.053432868 0.923522484 1 1.35769336 1.286435383 9404 leupaxin "GO:0002102,GO:0003712,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0006355,GO:0007155,GO:0007162,GO:0007165,GO:0007179,GO:0016020,GO:0016607,GO:0033628,GO:0034446,GO:0042995,GO:0043542,GO:0046872,GO:0048471,GO:0050859,GO:0065003" "podosome|transcription coregulator activity|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|focal adhesion|regulation of transcription, DNA-templated|cell adhesion|negative regulation of cell adhesion|signal transduction|transforming growth factor beta receptor signaling pathway|membrane|nuclear speck|regulation of cell adhesion mediated by integrin|substrate adhesion-dependent cell spreading|cell projection|endothelial cell migration|metal ion binding|perinuclear region of cytoplasm|negative regulation of B cell receptor signaling pathway|protein-containing complex assembly" LRATD2 130.8650507 130.0517353 131.678366 1.012507566 0.017932688 0.986857188 1 1.256903674 1.251328833 157638 LRAT domain containing 2 "GO:0005515,GO:0005737,GO:0005886" protein binding|cytoplasm|plasma membrane LRBA 2052.41737 2015.281691 2089.553048 1.036854082 0.052212877 0.827081412 1 8.915109408 9.088987327 987 LPS responsive beige-like anchor protein "GO:0003674,GO:0005764,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0019901" molecular_function|lysosome|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|protein localization|biological_process|membrane|integral component of membrane|protein kinase binding LRCH1 908.8617761 872.9072475 944.8163047 1.082378806 0.114205496 0.647964894 1 5.771955825 6.142900165 23143 leucine rich repeats and calponin homology domain containing 1 "GO:0005515,GO:0005737,GO:0034260,GO:1990869,GO:2000405" protein binding|cytoplasm|negative regulation of GTPase activity|cellular response to chemokine|negative regulation of T cell migration LRCH2 1027.717408 990.4740163 1064.960799 1.075203167 0.104609293 0.672230579 1 8.524395716 9.012085757 57631 leucine rich repeats and calponin homology domain containing 2 GO:0005515 protein binding LRCH3 1376.946071 1465.943161 1287.948981 0.878580436 -0.186753721 0.436722492 1 6.487122072 5.604085818 84859 leucine rich repeats and calponin homology domain containing 3 "GO:0005515,GO:0005737,GO:0005829,GO:0032185" protein binding|cytoplasm|cytosol|septin cytoskeleton organization LRCH4 263.6870118 273.6288511 253.7451724 0.927333398 -0.10883998 0.749825881 1 4.596496341 4.191157666 4034 leucine rich repeats and calponin homology domain containing 4 "GO:0005515,GO:0007399,GO:0016605" protein binding|nervous system development|PML body LRFN1 33.22404715 39.53572754 26.91236677 0.680710042 -0.554887701 0.438999823 1 0.559816693 0.374696107 57622 leucine rich repeat and fibronectin type III domain containing 1 "GO:0005886,GO:0009986,GO:0099061,GO:0099151" plasma membrane|cell surface|integral component of postsynaptic density membrane|regulation of postsynaptic density assembly LRFN3 181.3452456 181.0320156 181.6584757 1.003460493 0.004983818 1 1 2.059988475 2.032526647 79414 leucine rich repeat and fibronectin type III domain containing 3 "GO:0005886,GO:0009986,GO:0030424,GO:0030425,GO:0098978,GO:0099059,GO:0099061,GO:0099179,GO:0099560,GO:1905606" plasma membrane|cell surface|axon|dendrite|glutamatergic synapse|integral component of presynaptic active zone membrane|integral component of postsynaptic density membrane|regulation of synaptic membrane adhesion|synaptic membrane adhesion|regulation of presynapse assembly LRFN4 689.1545806 681.4710931 696.8380681 1.022549709 0.032170979 0.906098652 1 14.96045239 15.04181817 78999 leucine rich repeat and fibronectin type III domain containing 4 "GO:0005515,GO:0005886,GO:0009986,GO:0098978,GO:0098982,GO:0099061,GO:0099151,GO:0099560,GO:1905606" protein binding|plasma membrane|cell surface|glutamatergic synapse|GABA-ergic synapse|integral component of postsynaptic density membrane|regulation of postsynaptic density assembly|synaptic membrane adhesion|regulation of presynapse assembly LRG1 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.063944311 0 116844 leucine rich alpha-2-glycoprotein 1 "GO:0001938,GO:0003674,GO:0005160,GO:0005515,GO:0005576,GO:0005615,GO:0008150,GO:0009617,GO:0016020,GO:0030511,GO:0035580,GO:0043231,GO:0043312,GO:0045766,GO:0050873,GO:0070062,GO:1904724,GO:1904813" positive regulation of endothelial cell proliferation|molecular_function|transforming growth factor beta receptor binding|protein binding|extracellular region|extracellular space|biological_process|response to bacterium|membrane|positive regulation of transforming growth factor beta receptor signaling pathway|specific granule lumen|intracellular membrane-bounded organelle|neutrophil degranulation|positive regulation of angiogenesis|brown fat cell differentiation|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen LRGUK 13.53041089 14.56579436 12.49502743 0.857833574 -0.221230314 0.898154764 1 0.037781272 0.031867706 136332 leucine rich repeats and guanylate kinase domain containing "GO:0001669,GO:0002177,GO:0004385,GO:0005515,GO:0005524,GO:0005829,GO:0007283,GO:0016310,GO:0030154,GO:0035082,GO:0042995,GO:0046037,GO:0046710" acrosomal vesicle|manchette|guanylate kinase activity|protein binding|ATP binding|cytosol|spermatogenesis|phosphorylation|cell differentiation|axoneme assembly|cell projection|GMP metabolic process|GDP metabolic process LRIF1 532.1502352 521.2473552 543.0531151 1.041833804 0.059125154 0.832746237 1 7.345659714 7.524894741 55791 ligand dependent nuclear receptor interacting factor 1 "GO:0000781,GO:0001740,GO:0005515,GO:0005654,GO:0006355,GO:0009048,GO:0016363,GO:0034451,GO:0042974" "chromosome, telomeric region|Barr body|protein binding|nucleoplasm|regulation of transcription, DNA-templated|dosage compensation by inactivation of X chromosome|nuclear matrix|centriolar satellite|retinoic acid receptor binding" LRIG1 151.3462358 188.3149128 114.3775588 0.607373878 -0.719343234 0.074968435 1 1.795608502 1.072355889 26018 leucine rich repeats and immunoglobulin like domains 1 "GO:0005515,GO:0005615,GO:0005886,GO:0007605,GO:0016021,GO:0022405,GO:0031012,GO:0032474,GO:0060384" protein binding|extracellular space|plasma membrane|sensory perception of sound|integral component of membrane|hair cycle process|extracellular matrix|otolith morphogenesis|innervation LRIG2 573.9202759 621.1270879 526.7134639 0.847996286 -0.237870148 0.371087381 1 2.737501949 2.282546144 9860 leucine rich repeats and immunoglobulin like domains 2 "GO:0005102,GO:0005515,GO:0005615,GO:0005737,GO:0005886,GO:0007605,GO:0010640,GO:0016021,GO:0030426,GO:0031012,GO:0043025,GO:0048681,GO:0051045,GO:0060384,GO:0097708,GO:2000010,GO:2001222" signaling receptor binding|protein binding|extracellular space|cytoplasm|plasma membrane|sensory perception of sound|regulation of platelet-derived growth factor receptor signaling pathway|integral component of membrane|growth cone|extracellular matrix|neuronal cell body|negative regulation of axon regeneration|negative regulation of membrane protein ectodomain proteolysis|innervation|intracellular vesicle|positive regulation of protein localization to cell surface|regulation of neuron migration hsa04360 Axon guidance LRIG3 288.2455641 350.6194785 225.8716497 0.644207363 -0.634402945 0.047141398 1 4.306540196 2.727880669 121227 leucine rich repeats and immunoglobulin like domains 3 "GO:0005515,GO:0005615,GO:0005886,GO:0016021,GO:0030659,GO:0031012,GO:0032474" protein binding|extracellular space|plasma membrane|integral component of membrane|cytoplasmic vesicle membrane|extracellular matrix|otolith morphogenesis LRMDA 40.31382993 36.41448589 44.21317398 1.214164443 0.279963829 0.692667922 1 0.49525336 0.591256761 83938 leucine rich melanocyte differentiation associated GO:0030318 melanocyte differentiation LRP1 7217.784141 7595.021343 6840.546939 0.900661977 -0.150942338 0.537778455 1 26.92164785 23.84155877 4035 LDL receptor related protein 1 "GO:0001523,GO:0001540,GO:0002020,GO:0002265,GO:0003723,GO:0005041,GO:0005044,GO:0005509,GO:0005515,GO:0005634,GO:0005765,GO:0005769,GO:0005856,GO:0005886,GO:0005887,GO:0005905,GO:0005925,GO:0006629,GO:0006898,GO:0006909,GO:0007041,GO:0007204,GO:0007205,GO:0007568,GO:0008283,GO:0010715,GO:0010875,GO:0010942,GO:0010977,GO:0014912,GO:0015026,GO:0016020,GO:0016323,GO:0016964,GO:0021987,GO:0030136,GO:0030178,GO:0030226,GO:0030425,GO:0030666,GO:0031623,GO:0032050,GO:0032092,GO:0032370,GO:0032374,GO:0032429,GO:0032593,GO:0032956,GO:0034185,GO:0035774,GO:0035909,GO:0038023,GO:0038024,GO:0042157,GO:0042953,GO:0043025,GO:0043235,GO:0043277,GO:0043395,GO:0043524,GO:0044242,GO:0044295,GO:0044877,GO:0045056,GO:0045177,GO:0045807,GO:0048691,GO:0048694,GO:0050766,GO:0051481,GO:0051895,GO:0061642,GO:0070325,GO:0070374,GO:0097242,GO:0098797,GO:0150051,GO:0150093,GO:0150094,GO:0150104,GO:1900149,GO:1900223,GO:1903078,GO:1904109,GO:1904300,GO:1904646,GO:1904754,GO:1905049,GO:1905167,GO:2000343,GO:2000587" retinoid metabolic process|amyloid-beta binding|protease binding|astrocyte activation involved in immune response|RNA binding|low-density lipoprotein particle receptor activity|scavenger receptor activity|calcium ion binding|protein binding|nucleus|lysosomal membrane|early endosome|cytoskeleton|plasma membrane|integral component of plasma membrane|clathrin-coated pit|focal adhesion|lipid metabolic process|receptor-mediated endocytosis|phagocytosis|lysosomal transport|positive regulation of cytosolic calcium ion concentration|protein kinase C-activating G protein-coupled receptor signaling pathway|aging|cell population proliferation|regulation of extracellular matrix disassembly|positive regulation of cholesterol efflux|positive regulation of cell death|negative regulation of neuron projection development|negative regulation of smooth muscle cell migration|coreceptor activity|membrane|basolateral plasma membrane|alpha-2 macroglobulin receptor activity|cerebral cortex development|clathrin-coated vesicle|negative regulation of Wnt signaling pathway|apolipoprotein receptor activity|dendrite|endocytic vesicle membrane|receptor internalization|clathrin heavy chain binding|positive regulation of protein binding|positive regulation of lipid transport|regulation of cholesterol transport|regulation of phospholipase A2 activity|insulin-responsive compartment|regulation of actin cytoskeleton organization|apolipoprotein binding|positive regulation of insulin secretion involved in cellular response to glucose stimulus|aorta morphogenesis|signaling receptor activity|cargo receptor activity|lipoprotein metabolic process|lipoprotein transport|neuronal cell body|receptor complex|apoptotic cell clearance|heparan sulfate proteoglycan binding|negative regulation of neuron apoptotic process|cellular lipid catabolic process|axonal growth cone|protein-containing complex binding|transcytosis|apical part of cell|positive regulation of endocytosis|positive regulation of axon extension involved in regeneration|positive regulation of collateral sprouting of injured axon|positive regulation of phagocytosis|negative regulation of cytosolic calcium ion concentration|negative regulation of focal adhesion assembly|chemoattraction of axon|lipoprotein particle receptor binding|positive regulation of ERK1 and ERK2 cascade|amyloid-beta clearance|plasma membrane protein complex|postsynaptic Golgi apparatus|amyloid-beta clearance by transcytosis|amyloid-beta clearance by cellular catabolic process|transport across blood-brain barrier|positive regulation of Schwann cell migration|positive regulation of amyloid-beta clearance|positive regulation of protein localization to plasma membrane|positive regulation of cholesterol import|positive regulation of transcytosis|cellular response to amyloid-beta|positive regulation of vascular associated smooth muscle cell migration|negative regulation of metallopeptidase activity|positive regulation of lysosomal protein catabolic process|positive regulation of chemokine (C-X-C motif) ligand 2 production|negative regulation of platelet-derived growth factor receptor-beta signaling pathway "hsa04979,hsa05010,hsa05144" Cholesterol metabolism|Alzheimer disease|Malaria LRP10 3296.542094 3236.727589 3356.356598 1.036959863 0.052360054 0.826265347 1 35.26708913 35.9585972 26020 LDL receptor related protein 10 "GO:0005041,GO:0005515,GO:0005905,GO:0006629,GO:0006869,GO:0006897,GO:0016020,GO:0016021,GO:0048839" low-density lipoprotein particle receptor activity|protein binding|clathrin-coated pit|lipid metabolic process|lipid transport|endocytosis|membrane|integral component of membrane|inner ear development LRP11 790.600579 770.946687 810.2544709 1.050986384 0.071743979 0.780026811 1 7.018766248 7.253189884 84918 LDL receptor related protein 11 "GO:0005886,GO:0016021,GO:0051219" plasma membrane|integral component of membrane|phosphoprotein binding LRP12 1705.768391 1796.794775 1614.742006 0.898679153 -0.15412196 0.517106735 1 21.9030687 19.35444896 29967 LDL receptor related protein 12 "GO:0001764,GO:0005041,GO:0005515,GO:0005887,GO:0005905,GO:0006897,GO:0007165,GO:0016021,GO:0031175,GO:0040008" neuron migration|low-density lipoprotein particle receptor activity|protein binding|integral component of plasma membrane|clathrin-coated pit|endocytosis|signal transduction|integral component of membrane|neuron projection development|regulation of growth LRP1B 28.58181365 31.21241648 25.95121081 0.831438695 -0.266318203 0.755121625 1 0.077530803 0.063383423 53353 LDL receptor related protein 1B "GO:0005041,GO:0005509,GO:0005515,GO:0005886,GO:0006898,GO:0015031,GO:0016021,GO:0043235" low-density lipoprotein particle receptor activity|calcium ion binding|protein binding|plasma membrane|receptor-mediated endocytosis|protein transport|integral component of membrane|receptor complex LRP2BP 5.925451589 4.161655531 7.689247648 1.847641543 0.88568489 0.619277139 1 0.021740398 0.039496298 55805 LRP2 binding protein "GO:0005515,GO:0005737" protein binding|cytoplasm LRP3 81.63347521 61.38441908 101.8825313 1.659745793 0.730962295 0.146810359 1 0.798433738 1.30302166 4037 LDL receptor related protein 3 "GO:0005905,GO:0006898,GO:0010628,GO:0010629,GO:0016021,GO:0045599,GO:0045669,GO:0150104" clathrin-coated pit|receptor-mediated endocytosis|positive regulation of gene expression|negative regulation of gene expression|integral component of membrane|negative regulation of fat cell differentiation|positive regulation of osteoblast differentiation|transport across blood-brain barrier LRP4 370.3696781 387.0339643 353.7053918 0.913887215 -0.129911965 0.666096054 1 1.997030972 1.794521148 4038 LDL receptor related protein 4 "GO:0001822,GO:0001942,GO:0005509,GO:0005515,GO:0005886,GO:0006897,GO:0009953,GO:0009954,GO:0009986,GO:0014069,GO:0016021,GO:0016055,GO:0030279,GO:0030425,GO:0030971,GO:0031594,GO:0034185,GO:0042475,GO:0042733,GO:0042803,GO:0043025,GO:0044853,GO:0048813,GO:0050731,GO:0050771,GO:0050808,GO:0051124,GO:0060173,GO:0071340,GO:0090090,GO:0097060,GO:0097104,GO:0097105,GO:0097110,GO:0150094,GO:1901631,GO:1904395" kidney development|hair follicle development|calcium ion binding|protein binding|plasma membrane|endocytosis|dorsal/ventral pattern formation|proximal/distal pattern formation|cell surface|postsynaptic density|integral component of membrane|Wnt signaling pathway|negative regulation of ossification|dendrite|receptor tyrosine kinase binding|neuromuscular junction|apolipoprotein binding|odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|protein homodimerization activity|neuronal cell body|plasma membrane raft|dendrite morphogenesis|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of axonogenesis|synapse organization|synaptic growth at neuromuscular junction|limb development|skeletal muscle acetylcholine-gated channel clustering|negative regulation of canonical Wnt signaling pathway|synaptic membrane|postsynaptic membrane assembly|presynaptic membrane assembly|scaffold protein binding|amyloid-beta clearance by cellular catabolic process|positive regulation of presynaptic membrane organization|positive regulation of skeletal muscle acetylcholine-gated channel clustering LRP5 1563.692145 1561.661238 1565.723052 1.002600957 0.003747517 0.990513582 1 14.3053536 14.10255787 4041 LDL receptor related protein 5 "GO:0001702,GO:0002053,GO:0002076,GO:0005515,GO:0005783,GO:0005886,GO:0006007,GO:0006897,GO:0008203,GO:0008217,GO:0008284,GO:0009314,GO:0009952,GO:0015026,GO:0016021,GO:0017147,GO:0019534,GO:0033690,GO:0035019,GO:0035426,GO:0042074,GO:0042632,GO:0042733,GO:0042813,GO:0042981,GO:0043235,GO:0043434,GO:0045600,GO:0045668,GO:0045669,GO:0045840,GO:0045893,GO:0045944,GO:0046849,GO:0048539,GO:0051091,GO:0060033,GO:0060042,GO:0060070,GO:0060349,GO:0060444,GO:0060612,GO:0060764,GO:0061178,GO:0061304,GO:0071901,GO:0071936,GO:0110135,GO:1901998,GO:1902262,GO:1904928,GO:1990851,GO:1990909" "gastrulation with mouth forming second|positive regulation of mesenchymal cell proliferation|osteoblast development|protein binding|endoplasmic reticulum|plasma membrane|glucose catabolic process|endocytosis|cholesterol metabolic process|regulation of blood pressure|positive regulation of cell population proliferation|response to radiation|anterior/posterior pattern specification|coreceptor activity|integral component of membrane|Wnt-protein binding|toxin transmembrane transporter activity|positive regulation of osteoblast proliferation|somatic stem cell population maintenance|extracellular matrix-cell signaling|cell migration involved in gastrulation|cholesterol homeostasis|embryonic digit morphogenesis|Wnt-activated receptor activity|regulation of apoptotic process|receptor complex|response to peptide hormone|positive regulation of fat cell differentiation|negative regulation of osteoblast differentiation|positive regulation of osteoblast differentiation|positive regulation of mitotic nuclear division|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|bone remodeling|bone marrow development|positive regulation of DNA-binding transcription factor activity|anatomical structure regression|retina morphogenesis in camera-type eye|canonical Wnt signaling pathway|bone morphogenesis|branching involved in mammary gland duct morphogenesis|adipose tissue development|cell-cell signaling involved in mammary gland development|regulation of insulin secretion involved in cellular response to glucose stimulus|retinal blood vessel morphogenesis|negative regulation of protein serine/threonine kinase activity|coreceptor activity involved in Wnt signaling pathway|Norrin signaling pathway|toxin transport|apoptotic process involved in blood vessel morphogenesis|coreceptor activity involved in canonical Wnt signaling pathway|Wnt-Frizzled-LRP5/6 complex|Wnt signalosome" "hsa04150,hsa04310,hsa04928,hsa05010,hsa05022,hsa05200,hsa05224,hsa05225,hsa05226" "mTOR signaling pathway|Wnt signaling pathway|Parathyroid hormone synthesis, secretion and action|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Pathways in cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer" LRP6 1015.05822 1099.717474 930.3989654 0.846034538 -0.241211534 0.326267872 1 6.247594251 5.197231812 4040 LDL receptor related protein 6 "GO:0001843,GO:0001933,GO:0003344,GO:0005041,GO:0005102,GO:0005109,GO:0005515,GO:0005576,GO:0005769,GO:0005783,GO:0005794,GO:0005886,GO:0005901,GO:0006469,GO:0007204,GO:0007268,GO:0009880,GO:0009986,GO:0014029,GO:0014033,GO:0015026,GO:0016021,GO:0016055,GO:0017147,GO:0019210,GO:0019534,GO:0021587,GO:0021794,GO:0021987,GO:0030278,GO:0030326,GO:0030901,GO:0030917,GO:0031410,GO:0031901,GO:0034185,GO:0034392,GO:0035261,GO:0042475,GO:0042802,GO:0042803,GO:0042813,GO:0043025,GO:0043434,GO:0044335,GO:0044340,GO:0045202,GO:0045787,GO:0045893,GO:0045944,GO:0046849,GO:0048596,GO:0051091,GO:0060021,GO:0060026,GO:0060059,GO:0060070,GO:0060325,GO:0060349,GO:0060444,GO:0060535,GO:0071397,GO:0071542,GO:0071901,GO:0071936,GO:0072659,GO:0090009,GO:0090090,GO:0090118,GO:0090244,GO:0090245,GO:0098609,GO:1901998,GO:1904886,GO:1904928,GO:1904948,GO:1904953,GO:1990851,GO:1990909" "neural tube closure|negative regulation of protein phosphorylation|pericardium morphogenesis|low-density lipoprotein particle receptor activity|signaling receptor binding|frizzled binding|protein binding|extracellular region|early endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|caveola|negative regulation of protein kinase activity|positive regulation of cytosolic calcium ion concentration|chemical synaptic transmission|embryonic pattern specification|cell surface|neural crest formation|neural crest cell differentiation|coreceptor activity|integral component of membrane|Wnt signaling pathway|Wnt-protein binding|kinase inhibitor activity|toxin transmembrane transporter activity|cerebellum morphogenesis|thalamus development|cerebral cortex development|regulation of ossification|embryonic limb morphogenesis|midbrain development|midbrain-hindbrain boundary development|cytoplasmic vesicle|early endosome membrane|apolipoprotein binding|negative regulation of smooth muscle cell apoptotic process|external genitalia morphogenesis|odontogenesis of dentin-containing tooth|identical protein binding|protein homodimerization activity|Wnt-activated receptor activity|neuronal cell body|response to peptide hormone|canonical Wnt signaling pathway involved in neural crest cell differentiation|canonical Wnt signaling pathway involved in regulation of cell proliferation|synapse|positive regulation of cell cycle|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|bone remodeling|embryonic camera-type eye morphogenesis|positive regulation of DNA-binding transcription factor activity|roof of mouth development|convergent extension|embryonic retina morphogenesis in camera-type eye|canonical Wnt signaling pathway|face morphogenesis|bone morphogenesis|branching involved in mammary gland duct morphogenesis|trachea cartilage morphogenesis|cellular response to cholesterol|dopaminergic neuron differentiation|negative regulation of protein serine/threonine kinase activity|coreceptor activity involved in Wnt signaling pathway|protein localization to plasma membrane|primitive streak formation|negative regulation of canonical Wnt signaling pathway|receptor-mediated endocytosis involved in cholesterol transport|Wnt signaling pathway involved in somitogenesis|axis elongation involved in somitogenesis|cell-cell adhesion|toxin transport|beta-catenin destruction complex disassembly|coreceptor activity involved in canonical Wnt signaling pathway|midbrain dopaminergic neuron differentiation|Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|Wnt-Frizzled-LRP5/6 complex|Wnt signalosome" "hsa04150,hsa04310,hsa04928,hsa05010,hsa05022,hsa05200,hsa05224,hsa05225,hsa05226" "mTOR signaling pathway|Wnt signaling pathway|Parathyroid hormone synthesis, secretion and action|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Pathways in cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer" LRP8 1042.55496 1140.293615 944.8163047 0.828572827 -0.271299587 0.268181066 1 7.664404847 6.244250281 7804 LDL receptor related protein 8 "GO:0001523,GO:0001540,GO:0004888,GO:0005041,GO:0005509,GO:0005515,GO:0005615,GO:0005875,GO:0005886,GO:0005901,GO:0006508,GO:0006629,GO:0006897,GO:0007165,GO:0007268,GO:0008035,GO:0009986,GO:0014069,GO:0016020,GO:0016021,GO:0019221,GO:0019894,GO:0021517,GO:0021541,GO:0021819,GO:0030229,GO:0030424,GO:0030425,GO:0032793,GO:0034185,GO:0038024,GO:0038025,GO:0038026,GO:0042493,GO:0042981,GO:0043025,GO:0043235,GO:0045088,GO:0047485,GO:0048306,GO:0048813,GO:0050731,GO:0050804,GO:0061003,GO:0061098,GO:0071363,GO:0071397,GO:1900006" retinoid metabolic process|amyloid-beta binding|transmembrane signaling receptor activity|low-density lipoprotein particle receptor activity|calcium ion binding|protein binding|extracellular space|microtubule associated complex|plasma membrane|caveola|proteolysis|lipid metabolic process|endocytosis|signal transduction|chemical synaptic transmission|high-density lipoprotein particle binding|cell surface|postsynaptic density|membrane|integral component of membrane|cytokine-mediated signaling pathway|kinesin binding|ventral spinal cord development|ammon gyrus development|layer formation in cerebral cortex|very-low-density lipoprotein particle receptor activity|axon|dendrite|positive regulation of CREB transcription factor activity|apolipoprotein binding|cargo receptor activity|reelin receptor activity|reelin-mediated signaling pathway|response to drug|regulation of apoptotic process|neuronal cell body|receptor complex|regulation of innate immune response|protein N-terminus binding|calcium-dependent protein binding|dendrite morphogenesis|positive regulation of peptidyl-tyrosine phosphorylation|modulation of chemical synaptic transmission|positive regulation of dendritic spine morphogenesis|positive regulation of protein tyrosine kinase activity|cellular response to growth factor stimulus|cellular response to cholesterol|positive regulation of dendrite development LRPAP1 1482.485142 1435.771158 1529.199126 1.065071629 0.090950459 0.705185375 1 7.335292731 7.681878693 4043 LDL receptor related protein associated protein 1 "GO:0001540,GO:0002091,GO:0005102,GO:0005515,GO:0005576,GO:0005768,GO:0005783,GO:0005793,GO:0005794,GO:0005796,GO:0005801,GO:0005886,GO:0007165,GO:0008201,GO:0009986,GO:0010916,GO:0012505,GO:0031904,GO:0032091,GO:0035473,GO:0048018,GO:0048019,GO:0048237,GO:0048259,GO:0050750,GO:0060548,GO:0070326,GO:0150093,GO:1900116,GO:1900222,GO:1900223,GO:2000272" amyloid-beta binding|negative regulation of receptor internalization|signaling receptor binding|protein binding|extracellular region|endosome|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|Golgi lumen|cis-Golgi network|plasma membrane|signal transduction|heparin binding|cell surface|negative regulation of very-low-density lipoprotein particle clearance|endomembrane system|endosome lumen|negative regulation of protein binding|lipase binding|receptor ligand activity|receptor antagonist activity|rough endoplasmic reticulum lumen|regulation of receptor-mediated endocytosis|low-density lipoprotein particle receptor binding|negative regulation of cell death|very-low-density lipoprotein particle receptor binding|amyloid-beta clearance by transcytosis|extracellular negative regulation of signal transduction|negative regulation of amyloid-beta clearance|positive regulation of amyloid-beta clearance|negative regulation of signaling receptor activity hsa04979 Cholesterol metabolism LRPPRC 3072.819854 3368.860152 2776.779557 0.824248984 -0.278847892 0.239016654 1 27.11762815 21.97765239 10128 leucine rich pentatricopeptide repeat containing "GO:0000794,GO:0000961,GO:0003697,GO:0003723,GO:0005515,GO:0005634,GO:0005637,GO:0005640,GO:0005654,GO:0005739,GO:0005856,GO:0005874,GO:0008017,GO:0016020,GO:0031625,GO:0042645,GO:0047497,GO:0048471,GO:0048487,GO:0051015,GO:0051028,GO:0070129,GO:1990904" condensed nuclear chromosome|negative regulation of mitochondrial RNA catabolic process|single-stranded DNA binding|RNA binding|protein binding|nucleus|nuclear inner membrane|nuclear outer membrane|nucleoplasm|mitochondrion|cytoskeleton|microtubule|microtubule binding|membrane|ubiquitin protein ligase binding|mitochondrial nucleoid|mitochondrion transport along microtubule|perinuclear region of cytoplasm|beta-tubulin binding|actin filament binding|mRNA transport|regulation of mitochondrial translation|ribonucleoprotein complex LRR1 408.4888238 403.6805865 413.2970611 1.023821989 0.033964897 0.914833113 1 14.3433362 14.43928902 122769 leucine rich repeat protein 1 "GO:0005515,GO:0005829,GO:0016567,GO:0043687" protein binding|cytosol|protein ubiquitination|post-translational protein modification LRRC1 350.0073799 331.8920286 368.1227311 1.109164124 0.149472858 0.624396334 1 1.628133797 1.775648848 55227 leucine rich repeat containing 1 "GO:0005829,GO:0016020" cytosol|membrane LRRC14 346.8760774 350.6194785 343.1326763 0.97864693 -0.031139627 0.92771393 1 7.227468966 6.954780893 9684 leucine rich repeat containing 14 "GO:0005515,GO:0005737,GO:0019900,GO:0032088,GO:0034122" protein binding|cytoplasm|kinase binding|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway LRRC15 77.41709946 89.47559391 65.35860501 0.730462936 -0.453117023 0.381521227 1 0.804167733 0.577585133 131578 leucine rich repeat containing 15 "GO:0001968,GO:0005518,GO:0005615,GO:0016021,GO:0030335,GO:0031012,GO:0043236,GO:0046813,GO:0062023,GO:0070062,GO:1903077" fibronectin binding|collagen binding|extracellular space|integral component of membrane|positive regulation of cell migration|extracellular matrix|laminin binding|receptor-mediated virion attachment to host cell|collagen-containing extracellular matrix|extracellular exosome|negative regulation of protein localization to plasma membrane LRRC2 3.121241648 6.242483296 0 0 #NAME? 0.093640883 1 0.062610385 0 79442 leucine rich repeat containing 2 "GO:0004722,GO:0005737,GO:0006470,GO:0007165,GO:0043231" protein serine/threonine phosphatase activity|cytoplasm|protein dephosphorylation|signal transduction|intracellular membrane-bounded organelle LRRC20 1987.386471 1897.714922 2077.058021 1.094504763 0.130278233 0.582899936 1 30.83030671 33.17925877 55222 leucine rich repeat containing 20 GO:0005515 protein binding LRRC23 149.4736136 164.3853935 134.5618338 0.818575367 -0.288812841 0.482895826 1 5.748981862 4.627226822 10233 leucine rich repeat containing 23 "GO:0003674,GO:0005515,GO:0005575,GO:0005737,GO:0005829,GO:0008150" molecular_function|protein binding|cellular_component|cytoplasm|cytosol|biological_process LRRC24 2.923096831 1.040413883 4.80577978 4.619103859 2.207612985 0.416510993 1 0.031512473 0.143123645 441381 leucine rich repeat containing 24 "GO:0005615,GO:0016021,GO:0031012,GO:0051965" extracellular space|integral component of membrane|extracellular matrix|positive regulation of synapse assembly LRRC27 57.7234632 64.50566072 50.94126567 0.789717756 -0.340590966 0.563710803 1 0.919975563 0.714363692 80313 leucine rich repeat containing 27 LRRC28 336.5908254 332.9324424 340.2492084 1.021976729 0.031362345 0.92814279 1 1.917547221 1.926895901 123355 leucine rich repeat containing 28 LRRC29 22.09652615 24.96993318 19.22311912 0.769850643 -0.377349516 0.680227645 1 0.401143721 0.303653055 26231 leucine rich repeat containing 29 GO:0005515 protein binding LRRC34 12.97057499 12.48496659 13.45618338 1.0777909 0.108077311 1 1 0.143971418 0.152574506 151827 leucine rich repeat containing 34 "GO:0003674,GO:0005575,GO:0005730,GO:0005737,GO:0008150,GO:0030154" molecular_function|cellular_component|nucleolus|cytoplasm|biological_process|cell differentiation LRRC37A 10.04747816 11.44455271 8.650403604 0.755853359 -0.403821727 0.795727704 1 0.11797851 0.087682239 9884 leucine rich repeat containing 37A GO:0016021 integral component of membrane LRRC37A2 7.966650391 7.282897178 8.650403604 1.187769564 0.248254969 0.952730603 1 0.103729607 0.12114517 474170 leucine rich repeat containing 37 member A2 GO:0016021 integral component of membrane LRRC37A3 14.49156685 14.56579436 14.41733934 0.98980797 -0.014779436 1 1 0.128742907 0.125298375 374819 leucine rich repeat containing 37 member A3 GO:0016021 integral component of membrane LRRC37B 226.529022 256.982229 196.075815 0.762993674 -0.390257 0.26154744 1 3.44416606 2.583902954 114659 leucine rich repeat containing 37B GO:0016021 integral component of membrane LRRC39 5.603389465 8.323311061 2.883467868 0.346432789 -1.529352609 0.352439314 1 0.230274657 0.07843977 127495 leucine rich repeat containing 39 "GO:0004722,GO:0005515,GO:0005737,GO:0006470,GO:0007165,GO:0031430,GO:0043231" protein serine/threonine phosphatase activity|protein binding|cytoplasm|protein dephosphorylation|signal transduction|M band|intracellular membrane-bounded organelle LRRC3B 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.015516994 0 116135 leucine rich repeat containing 3B "GO:0005515,GO:0005615,GO:0016021,GO:0031012" protein binding|extracellular space|integral component of membrane|extracellular matrix LRRC40 849.0870533 830.2502783 867.9238283 1.045376136 0.064022131 0.801847768 1 15.74588892 16.18493441 55631 leucine rich repeat containing 40 "GO:0004722,GO:0005515,GO:0005737,GO:0006470,GO:0007165,GO:0016020,GO:0043231" protein serine/threonine phosphatase activity|protein binding|cytoplasm|protein dephosphorylation|signal transduction|membrane|intracellular membrane-bounded organelle LRRC41 1603.683913 1602.237379 1605.130447 1.001805642 0.002602642 0.994280744 1 20.67419346 20.36494435 10489 leucine rich repeat containing 41 "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0016020,GO:0016567,GO:0043687" protein binding|nucleus|cytoplasm|cytosol|membrane|protein ubiquitination|post-translational protein modification LRRC42 1490.819128 1326.5277 1655.110556 1.247701466 0.319272786 0.181150098 1 36.68100793 45.00109949 115353 leucine rich repeat containing 42 LRRC45 581.2037875 534.7727357 627.6348393 1.17364779 0.230999522 0.384168618 1 10.57814605 12.20726922 201255 leucine rich repeat containing 45 "GO:0005515,GO:0005654,GO:0005813,GO:0005829,GO:0005886" protein binding|nucleoplasm|centrosome|cytosol|plasma membrane LRRC46 8.566115259 10.40413883 6.728091692 0.64667454 -0.628888283 0.669388466 1 0.329525084 0.209529618 90506 leucine rich repeat containing 46 LRRC47 1109.543997 1069.545471 1149.542523 1.074795373 0.104062015 0.671653428 1 13.26508856 14.01867993 57470 leucine rich repeat containing 47 "GO:0003723,GO:0004826,GO:0005515" RNA binding|phenylalanine-tRNA ligase activity|protein binding LRRC49 262.0421026 280.9117483 243.1724569 0.865654279 -0.208137132 0.532915799 1 4.102830792 3.492201261 54839 leucine rich repeat containing 49 "GO:0005737,GO:0005874,GO:0036158" cytoplasm|microtubule|outer dynein arm assembly LRRC51 24.49941604 24.96993318 24.0288989 0.962313304 -0.055421421 1 1 0.625927403 0.592258952 120356739 leucine-rich repeat-containing protein 51 LRRC56 33.90276995 44.73779695 23.06774294 0.515620896 -0.955617364 0.169113493 1 0.534731019 0.271104711 115399 leucine rich repeat containing 56 "GO:0005515,GO:0005929,GO:0030030" protein binding|cilium|cell projection organization LRRC57 334.3068224 336.0536841 332.5599608 0.989603675 -0.015077237 0.971436775 1 2.465910557 2.399439466 255252 leucine rich repeat containing 57 "GO:0016020,GO:0070062" membrane|extracellular exosome LRRC58 2188.690852 2438.730141 1938.651563 0.794943045 -0.331076596 0.161402981 1 16.43730051 12.84806389 116064 leucine rich repeat containing 58 LRRC59 5201.327675 5287.383352 5115.271998 0.967448671 -0.047742975 0.843264672 1 97.9784485 93.20295226 55379 leucine rich repeat containing 59 "GO:0003723,GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0007165,GO:0016020,GO:0016021,GO:0042645,GO:0045296,GO:0046579" RNA binding|protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|signal transduction|membrane|integral component of membrane|mitochondrial nucleoid|cadherin binding|positive regulation of Ras protein signal transduction LRRC61 318.2150058 317.3262342 319.1037774 1.005601627 0.008058889 0.990830169 1 6.115968905 6.04731254 65999 leucine rich repeat containing 61 "GO:0005515,GO:0005737,GO:0005829" protein binding|cytoplasm|cytosol LRRC63 21.77446403 29.13158871 14.41733934 0.494903985 -1.014779436 0.221521684 1 0.170061184 0.082755588 220416 leucine rich repeat containing 63 LRRC69 10.16636505 14.56579436 5.766935736 0.395923188 -1.336707531 0.252942837 1 0.587565891 0.228738197 100130742 leucine rich repeat containing 69 GO:0007165 signal transduction LRRC7 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.006684119 0.009107398 57554 leucine rich repeat containing 7 "GO:0000165,GO:0005515,GO:0005576,GO:0005654,GO:0005813,GO:0005829,GO:0005886,GO:0008328,GO:0009790,GO:0010976,GO:0014069,GO:0016323,GO:0030054,GO:0035580,GO:0043113,GO:0043194,GO:0043312,GO:0045197,GO:0097120,GO:0098609,GO:2000310" MAPK cascade|protein binding|extracellular region|nucleoplasm|centrosome|cytosol|plasma membrane|ionotropic glutamate receptor complex|embryo development|positive regulation of neuron projection development|postsynaptic density|basolateral plasma membrane|cell junction|specific granule lumen|receptor clustering|axon initial segment|neutrophil degranulation|establishment or maintenance of epithelial cell apical/basal polarity|receptor localization to synapse|cell-cell adhesion|regulation of NMDA receptor activity LRRC70 9.408384325 7.282897178 11.53387147 1.583692752 0.663292469 0.627344635 1 0.179692481 0.279815658 100130733 leucine rich repeat containing 70 "GO:0005887,GO:0060760" integral component of plasma membrane|positive regulation of response to cytokine stimulus LRRC71 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.052022152 0.078758233 149499 leucine rich repeat containing 71 LRRC73 4.404459729 2.080827765 6.728091692 3.233372701 1.693039812 0.389066599 1 0.062212859 0.197791264 221424 leucine rich repeat containing 73 GO:0005515 protein binding LRRC75A 26.34247003 22.88910542 29.79583464 1.301747451 0.380449582 0.649069058 1 0.315645862 0.404015489 388341 leucine rich repeat containing 75A GO:0005737 cytoplasm LRRC75B 98.95882012 99.87973273 98.03790751 0.98155957 -0.026852269 0.97851228 1 3.551231023 3.427415577 388886 leucine rich repeat containing 75B GO:0005737 cytoplasm LRRC8A 2246.475909 2151.575909 2341.375909 1.08821441 0.121962838 0.606779112 1 21.79268397 23.31827244 56262 leucine rich repeat containing 8 VRAC subunit A "GO:0002329,GO:0005225,GO:0005253,GO:0005515,GO:0005886,GO:0005887,GO:0006820,GO:0006884,GO:0006970,GO:0009986,GO:0015698,GO:0015734,GO:0015810,GO:0016020,GO:0034214,GO:0034702,GO:0042802,GO:0055085,GO:0098656" pre-B cell differentiation|volume-sensitive anion channel activity|anion channel activity|protein binding|plasma membrane|integral component of plasma membrane|anion transport|cell volume homeostasis|response to osmotic stress|cell surface|inorganic anion transport|taurine transport|aspartate transmembrane transport|membrane|protein hexamerization|ion channel complex|identical protein binding|transmembrane transport|anion transmembrane transport LRRC8B 62.07823312 90.51600779 33.64045846 0.371652035 -1.427975589 0.010770143 0.620526829 0.411226098 0.150275562 23507 leucine rich repeat containing 8 VRAC subunit B "GO:0005225,GO:0005515,GO:0005737,GO:0005789,GO:0005886,GO:0005887,GO:0015698,GO:0034702,GO:0055085,GO:0098656" volume-sensitive anion channel activity|protein binding|cytoplasm|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|inorganic anion transport|ion channel complex|transmembrane transport|anion transmembrane transport LRRC8C 1990.253619 2137.010115 1843.497124 0.862652503 -0.213148571 0.367972043 1 12.26457707 10.40302499 84230 leucine rich repeat containing 8 VRAC subunit C "GO:0005225,GO:0005515,GO:0005737,GO:0005789,GO:0005886,GO:0005887,GO:0015698,GO:0015734,GO:0015810,GO:0016020,GO:0034214,GO:0034702,GO:0055085,GO:0071470,GO:0098656" volume-sensitive anion channel activity|protein binding|cytoplasm|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|inorganic anion transport|taurine transport|aspartate transmembrane transport|membrane|protein hexamerization|ion channel complex|transmembrane transport|cellular response to osmotic stress|anion transmembrane transport LRRC8D 1142.930362 1302.598181 983.262543 0.754847164 -0.405743527 0.094986651 1 17.10562767 12.69606745 55144 leucine rich repeat containing 8 VRAC subunit D "GO:0005225,GO:0005515,GO:0005737,GO:0005789,GO:0005886,GO:0005887,GO:0015698,GO:0015734,GO:0015810,GO:0016020,GO:0034702,GO:0055085,GO:0071470,GO:0098656" volume-sensitive anion channel activity|protein binding|cytoplasm|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|inorganic anion transport|taurine transport|aspartate transmembrane transport|membrane|ion channel complex|transmembrane transport|cellular response to osmotic stress|anion transmembrane transport LRRC8E 421.7613392 461.9437639 381.5789145 0.826028933 -0.275735779 0.334720573 1 5.409938482 4.393986971 80131 leucine rich repeat containing 8 VRAC subunit E "GO:0005225,GO:0005515,GO:0005737,GO:0005789,GO:0005886,GO:0005887,GO:0015698,GO:0015810,GO:0034702,GO:0055085,GO:0071470,GO:0098656" volume-sensitive anion channel activity|protein binding|cytoplasm|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|inorganic anion transport|aspartate transmembrane transport|ion channel complex|transmembrane transport|cellular response to osmotic stress|anion transmembrane transport LRRCC1 533.5523401 520.2069413 546.897739 1.051308038 0.072185448 0.794676174 1 7.197948758 7.440633517 85444 leucine rich repeat and coiled-coil centrosomal protein 1 "GO:0005737,GO:0005813,GO:0005814,GO:0007049,GO:0051301" cytoplasm|centrosome|centriole|cell cycle|cell division LRRFIP1 2334.984088 2544.852357 2125.115819 0.835064483 -0.260040489 0.271312835 1 17.28794463 14.19497247 9208 LRR binding FLII interacting protein 1 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0003725,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006357,GO:0032481,GO:0042803,GO:0045296,GO:0051092" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|double-stranded RNA binding|protein binding|nucleus|cytoplasm|cytosol|cytoskeleton|plasma membrane|regulation of transcription by RNA polymerase II|positive regulation of type I interferon production|protein homodimerization activity|cadherin binding|positive regulation of NF-kappaB transcription factor activity" LRRFIP2 1305.4305 1241.213762 1369.647237 1.103474099 0.142052766 0.556299431 1 15.43726339 16.74956901 9209 LRR binding FLII interacting protein 2 "GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0016055,GO:0030275" "protein binding|cellular_component|regulation of transcription, DNA-templated|biological_process|Wnt signaling pathway|LRR domain binding" LRRIQ3 13.89210198 11.44455271 16.33965125 1.427723011 0.513716113 0.649021464 1 0.166061649 0.233122656 127255 leucine rich repeats and IQ motif containing 3 GO:0005515 protein binding LRRK1 1039.616158 1277.628248 801.6040673 0.627415736 -0.672506382 0.006134987 0.469832129 6.246305552 3.853450728 79705 leucine rich repeat kinase 1 "GO:0004722,GO:0005515,GO:0005524,GO:0005525,GO:0005737,GO:0005739,GO:0005829,GO:0006468,GO:0006470,GO:0007165,GO:0036035,GO:0042802,GO:0043231,GO:0045453,GO:0046872,GO:0050731,GO:0050732,GO:0090263,GO:0106310,GO:0106311,GO:1902533" protein serine/threonine phosphatase activity|protein binding|ATP binding|GTP binding|cytoplasm|mitochondrion|cytosol|protein phosphorylation|protein dephosphorylation|signal transduction|osteoclast development|identical protein binding|intracellular membrane-bounded organelle|bone resorption|metal ion binding|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of peptidyl-tyrosine phosphorylation|positive regulation of canonical Wnt signaling pathway|protein serine kinase activity|protein threonine kinase activity|positive regulation of intracellular signal transduction LRRN4 802.4603142 956.1403581 648.7802703 0.678540828 -0.559492469 0.026148302 0.866576205 9.081233957 6.058875484 164312 leucine rich repeat neuronal 4 "GO:0005515,GO:0005887,GO:0007616,GO:0008542,GO:0070062" protein binding|integral component of plasma membrane|long-term memory|visual learning|extracellular exosome LRRTM2 13.1687198 17.687036 8.650403604 0.489081585 -1.03185295 0.321609015 1 0.15566039 0.074856687 26045 leucine rich repeat transmembrane neuronal 2 "GO:0002091,GO:0005515,GO:0005615,GO:0042043,GO:0050808,GO:0051965,GO:0060076,GO:0060291,GO:0098685,GO:0098686,GO:0098978,GO:0098982,GO:0099060,GO:0099061,GO:0099151" negative regulation of receptor internalization|protein binding|extracellular space|neurexin family protein binding|synapse organization|positive regulation of synapse assembly|excitatory synapse|long-term synaptic potentiation|Schaffer collateral - CA1 synapse|hippocampal mossy fiber to CA3 synapse|glutamatergic synapse|GABA-ergic synapse|integral component of postsynaptic specialization membrane|integral component of postsynaptic density membrane|regulation of postsynaptic density assembly LRRTM4 10.52805613 11.44455271 9.61155956 0.839837065 -0.251818634 0.906931683 1 0.125725555 0.103822092 80059 leucine rich repeat transmembrane neuronal 4 "GO:0005615,GO:0016021,GO:0031012,GO:0045211" extracellular space|integral component of membrane|extracellular matrix|postsynaptic membrane LRSAM1 804.7304547 788.633723 820.8271864 1.040821819 0.057723112 0.82285539 1 9.426188657 9.646809316 90678 leucine rich repeat and sterile alpha motif containing 1 "GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0006914,GO:0016020,GO:0030163,GO:0045806,GO:0046755,GO:0046872,GO:0051865,GO:0061630,GO:0070086,GO:1904417,GO:2000786" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|autophagy|membrane|protein catabolic process|negative regulation of endocytosis|viral budding|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|ubiquitin-dependent endocytosis|positive regulation of xenophagy|positive regulation of autophagosome assembly LRTOMT 4.885037707 2.080827765 7.689247648 3.695283087 1.88568489 0.299624042 1 0.033539702 0.121864747 220074 leucine rich transmembrane and O-methyltransferase domain containing "GO:0005575,GO:0005783,GO:0005886,GO:0007605,GO:0008171,GO:0016021,GO:0016206,GO:0032259,GO:0032502,GO:0042135,GO:0042417,GO:0042424,GO:0060117,GO:0102084,GO:0102938" cellular_component|endoplasmic reticulum|plasma membrane|sensory perception of sound|O-methyltransferase activity|integral component of membrane|catechol O-methyltransferase activity|methylation|developmental process|neurotransmitter catabolic process|dopamine metabolic process|catecholamine catabolic process|auditory receptor cell development|L-dopa O-methyltransferase activity|orcinol O-methyltransferase activity "hsa00140,hsa00350,hsa04728" Steroid hormone biosynthesis|Tyrosine metabolism|Dopaminergic synapse LRWD1 552.8547172 522.2877691 583.4216653 1.117050216 0.159694042 0.55347364 1 12.90441589 14.17366705 222229 leucine rich repeats and WD repeat domain containing 1 "GO:0000776,GO:0000777,GO:0000781,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005664,GO:0005721,GO:0005730,GO:0005737,GO:0005815,GO:0006270,GO:0006325,GO:0008327,GO:0035064,GO:0043231,GO:0071169" "kinetochore|condensed chromosome kinetochore|chromosome, telomeric region|chromatin binding|protein binding|nucleus|nucleoplasm|nuclear origin of replication recognition complex|pericentric heterochromatin|nucleolus|cytoplasm|microtubule organizing center|DNA replication initiation|chromatin organization|methyl-CpG binding|methylated histone binding|intracellular membrane-bounded organelle|establishment of protein localization to chromatin" LSG1 977.9989952 1136.13196 819.8660305 0.721629229 -0.47067032 0.055999889 1 17.5748622 12.47030922 55341 large 60S subunit nuclear export GTPase 1 "GO:0000054,GO:0003924,GO:0005525,GO:0005654,GO:0005783,GO:0005829,GO:0015030,GO:0016020,GO:0016604,GO:0051168" ribosomal subunit export from nucleus|GTPase activity|GTP binding|nucleoplasm|endoplasmic reticulum|cytosol|Cajal body|membrane|nuclear body|nuclear export hsa03008 Ribosome biogenesis in eukaryotes LSM1 434.0437449 393.2764476 474.8110423 1.207321326 0.271809697 0.33829201 1 23.16604989 27.50084497 27257 "LSM1 homolog, mRNA degradation associated" "GO:0000290,GO:0000339,GO:0000375,GO:0000932,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006397,GO:0008380,GO:0016070,GO:0019827,GO:0030424,GO:0030425,GO:0036002,GO:0043025,GO:0043928,GO:0045665,GO:0071044,GO:1990124,GO:1990726" "deadenylation-dependent decapping of nuclear-transcribed mRNA|RNA cap binding|RNA splicing, via transesterification reactions|P-body|RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|cytosol|mRNA processing|RNA splicing|RNA metabolic process|stem cell population maintenance|axon|dendrite|pre-mRNA binding|neuronal cell body|exonucleolytic catabolism of deadenylated mRNA|negative regulation of neuron differentiation|histone mRNA catabolic process|messenger ribonucleoprotein complex|Lsm1-7-Pat1 complex" hsa03018 RNA degradation LSM10 317.2538498 317.3262342 317.1814655 0.999543786 -0.000658328 1 1 19.69199756 19.35364521 84967 "LSM10, U7 small nuclear RNA associated" "GO:0005515,GO:0005654,GO:0005683,GO:0006369,GO:0006397,GO:0008334,GO:0008380,GO:0015030,GO:0016604,GO:0071208,GO:0071209,GO:1900087" protein binding|nucleoplasm|U7 snRNP|termination of RNA polymerase II transcription|mRNA processing|histone mRNA metabolic process|RNA splicing|Cajal body|nuclear body|histone pre-mRNA DCP binding|U7 snRNA binding|positive regulation of G1/S transition of mitotic cell cycle LSM11 458.6419262 471.3074888 445.9763636 0.946253506 -0.079701355 0.781662727 1 3.83018341 3.563676317 134353 "LSM11, U7 small nuclear RNA associated" "GO:0005515,GO:0005634,GO:0005654,GO:0005683,GO:0005697,GO:0006369,GO:0006398,GO:0008334,GO:0016604,GO:0071204,GO:0071209,GO:1900087" protein binding|nucleus|nucleoplasm|U7 snRNP|telomerase holoenzyme complex|termination of RNA polymerase II transcription|mRNA 3'-end processing by stem-loop binding and cleavage|histone mRNA metabolic process|nuclear body|histone pre-mRNA 3'end processing complex|U7 snRNA binding|positive regulation of G1/S transition of mitotic cell cycle LSM12 428.9108726 409.9230698 447.8986755 1.092640811 0.127819215 0.657825132 1 5.893545481 6.33177153 124801 LSM12 homolog GO:0005515 protein binding LSM14A 2129.021768 2133.888873 2124.154663 0.995438277 -0.006596232 0.979966664 1 31.07277687 30.41344254 26065 LSM14A mRNA processing body assembly factor "GO:0000932,GO:0003690,GO:0003723,GO:0003725,GO:0003727,GO:0003729,GO:0005515,GO:0005737,GO:0005829,GO:0007275,GO:0010494,GO:0017148,GO:0033962,GO:0034063,GO:0036464,GO:0039529,GO:0060340,GO:0072686,GO:0090307,GO:1990124" P-body|double-stranded DNA binding|RNA binding|double-stranded RNA binding|single-stranded RNA binding|mRNA binding|protein binding|cytoplasm|cytosol|multicellular organism development|cytoplasmic stress granule|negative regulation of translation|P-body assembly|stress granule assembly|cytoplasmic ribonucleoprotein granule|RIG-I signaling pathway|positive regulation of type I interferon-mediated signaling pathway|mitotic spindle|mitotic spindle assembly|messenger ribonucleoprotein complex LSM14B 1759.484298 1768.7036 1750.264996 0.989575074 -0.015118934 0.95175973 1 29.17850399 28.3911476 149986 LSM family member 14B "GO:0003723,GO:0003729,GO:0005515,GO:0006417,GO:0007275" RNA binding|mRNA binding|protein binding|regulation of translation|multicellular organism development LSM2 512.0703701 460.90335 563.2373902 1.222029283 0.289278856 0.288109687 1 28.66849031 34.44749255 57819 "LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated" "GO:0000244,GO:0000398,GO:0000932,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005688,GO:0005737,GO:0005829,GO:0006402,GO:0017070,GO:0031267,GO:0043928,GO:0046540,GO:0071005,GO:0071011,GO:0071013,GO:0120115,GO:1990726" "spliceosomal tri-snRNP complex assembly|mRNA splicing, via spliceosome|P-body|RNA binding|protein binding|nucleus|nucleoplasm|U6 snRNP|cytoplasm|cytosol|mRNA catabolic process|U6 snRNA binding|small GTPase binding|exonucleolytic catabolism of deadenylated mRNA|U4/U6 x U5 tri-snRNP complex|U2-type precatalytic spliceosome|precatalytic spliceosome|catalytic step 2 spliceosome|Lsm2-8 complex|Lsm1-7-Pat1 complex" "hsa03018,hsa03040" RNA degradation|Spliceosome LSM3 797.1361706 652.3395044 941.9328369 1.443930393 0.530001196 0.03536253 0.95006405 10.36444192 14.71510477 27258 "LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated" "GO:0000398,GO:0000932,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005688,GO:0005829,GO:0006397,GO:0030629,GO:0033962,GO:0043928,GO:0046540,GO:0071005,GO:0071011,GO:0071013,GO:0120115,GO:1990726" "mRNA splicing, via spliceosome|P-body|RNA binding|protein binding|nucleus|nucleoplasm|U6 snRNP|cytosol|mRNA processing|U6 snRNA 3'-end binding|P-body assembly|exonucleolytic catabolism of deadenylated mRNA|U4/U6 x U5 tri-snRNP complex|U2-type precatalytic spliceosome|precatalytic spliceosome|catalytic step 2 spliceosome|Lsm2-8 complex|Lsm1-7-Pat1 complex" "hsa03018,hsa03040" RNA degradation|Spliceosome LSM4 1863.854622 1657.379315 2070.329929 1.249158784 0.320956873 0.175559743 1 51.90803281 63.75634253 25804 "LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated" "GO:0000387,GO:0000398,GO:0000932,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005688,GO:0005829,GO:0008380,GO:0016020,GO:0017070,GO:0032991,GO:0033962,GO:0042731,GO:0043928,GO:0046540,GO:0071005,GO:0097526,GO:0120115" "spliceosomal snRNP assembly|mRNA splicing, via spliceosome|P-body|RNA binding|protein binding|nucleus|nucleoplasm|U6 snRNP|cytosol|RNA splicing|membrane|U6 snRNA binding|protein-containing complex|P-body assembly|PH domain binding|exonucleolytic catabolism of deadenylated mRNA|U4/U6 x U5 tri-snRNP complex|U2-type precatalytic spliceosome|spliceosomal tri-snRNP complex|Lsm2-8 complex" "hsa03018,hsa03040" RNA degradation|Spliceosome LSM5 683.6505707 625.2887435 742.012398 1.186671607 0.246920747 0.337896939 1 13.31093379 15.53138742 23658 "LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated" "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005688,GO:0005737,GO:0005829,GO:0006397,GO:0006402,GO:0009617,GO:0043928,GO:0046540,GO:0046982,GO:0071005,GO:0120115,GO:1990726" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U6 snRNP|cytoplasm|cytosol|mRNA processing|mRNA catabolic process|response to bacterium|exonucleolytic catabolism of deadenylated mRNA|U4/U6 x U5 tri-snRNP complex|protein heterodimerization activity|U2-type precatalytic spliceosome|Lsm2-8 complex|Lsm1-7-Pat1 complex" "hsa03018,hsa03040" RNA degradation|Spliceosome LSM6 347.6441189 332.9324424 362.3557954 1.088376347 0.122177508 0.69146736 1 15.04487091 16.10047687 11157 "LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated" "GO:0000398,GO:0000932,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005688,GO:0005730,GO:0005732,GO:0005737,GO:0005829,GO:0006402,GO:0008033,GO:0008380,GO:0030490,GO:0030532,GO:0043928,GO:0046540,GO:0046982,GO:0071005,GO:0120115" "mRNA splicing, via spliceosome|P-body|RNA binding|protein binding|nucleus|nucleoplasm|U6 snRNP|nucleolus|sno(s)RNA-containing ribonucleoprotein complex|cytoplasm|cytosol|mRNA catabolic process|tRNA processing|RNA splicing|maturation of SSU-rRNA|small nuclear ribonucleoprotein complex|exonucleolytic catabolism of deadenylated mRNA|U4/U6 x U5 tri-snRNP complex|protein heterodimerization activity|U2-type precatalytic spliceosome|Lsm2-8 complex" "hsa03018,hsa03040" RNA degradation|Spliceosome LSM7 427.4691387 409.9230698 445.0152076 1.085606643 0.118501454 0.682261241 1 33.04658735 35.27526526 51690 "LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated" "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005688,GO:0005689,GO:0005829,GO:0017070,GO:0043928,GO:0046540,GO:0071004,GO:0071005,GO:0071013,GO:0097526,GO:0120115,GO:1990726,GO:1990904" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U6 snRNP|U12-type spliceosomal complex|cytosol|U6 snRNA binding|exonucleolytic catabolism of deadenylated mRNA|U4/U6 x U5 tri-snRNP complex|U2-type prespliceosome|U2-type precatalytic spliceosome|catalytic step 2 spliceosome|spliceosomal tri-snRNP complex|Lsm2-8 complex|Lsm1-7-Pat1 complex|ribonucleoprotein complex" "hsa03018,hsa03040" RNA degradation|Spliceosome LSM8 1065.272302 916.6046306 1213.939972 1.324387781 0.405325605 0.097372684 1 3.950056887 5.143866561 51691 "LSM8 homolog, U6 small nuclear RNA associated" "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005688,GO:0016070,GO:0017070,GO:0046540,GO:0071005,GO:0071011,GO:0120115" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U6 snRNP|RNA metabolic process|U6 snRNA binding|U4/U6 x U5 tri-snRNP complex|U2-type precatalytic spliceosome|precatalytic spliceosome|Lsm2-8 complex" "hsa03018,hsa03040" RNA degradation|Spliceosome LSMEM1 59.73006345 54.1015219 65.35860501 1.208073317 0.272708013 0.645973711 1 0.425604185 0.50555727 286006 leucine rich single-pass membrane protein 1 "GO:0005515,GO:0016021" protein binding|integral component of membrane LSP1 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.0164616 0.05981236 4046 lymphocyte specific protein 1 "GO:0003779,GO:0005886,GO:0006968,GO:0007165,GO:0015629,GO:0016020,GO:0070062" actin binding|plasma membrane|cellular defense response|signal transduction|actin cytoskeleton|membrane|extracellular exosome "hsa04625,hsa05152" C-type lectin receptor signaling pathway|Tuberculosis LSR 14.8928869 12.48496659 17.30080721 1.385731158 0.470647391 0.669945395 1 0.30313909 0.413039992 51599 lipolysis stimulated lipoprotein receptor "GO:0001889,GO:0005886,GO:0016021,GO:0019216,GO:0034361,GO:0034362,GO:0035633,GO:0042627,GO:0060856,GO:0061436,GO:0061689,GO:0061833,GO:0070062,GO:1904274" liver development|plasma membrane|integral component of membrane|regulation of lipid metabolic process|very-low-density lipoprotein particle|low-density lipoprotein particle|maintenance of blood-brain barrier|chylomicron|establishment of blood-brain barrier|establishment of skin barrier|tricellular tight junction|protein localization to tricellular tight junction|extracellular exosome|tricellular tight junction assembly LSS 1784.196336 1862.34085 1706.051822 0.916079257 -0.126455673 0.594942511 1 19.80663777 17.84082721 4047 lanosterol synthase "GO:0000250,GO:0005515,GO:0005789,GO:0005811,GO:0006694,GO:0006695,GO:0016020,GO:0016104,GO:0031647,GO:0042300,GO:0045540" lanosterol synthase activity|protein binding|endoplasmic reticulum membrane|lipid droplet|steroid biosynthetic process|cholesterol biosynthetic process|membrane|triterpenoid biosynthetic process|regulation of protein stability|beta-amyrin synthase activity|regulation of cholesterol biosynthetic process hsa00100 Steroid biosynthesis LST1 8.045908318 9.363724944 6.728091692 0.718527267 -0.476885189 0.786592357 1 0.562120124 0.39713994 7940 leukocyte specific transcript 1 "GO:0000139,GO:0000902,GO:0005737,GO:0005794,GO:0006955,GO:0008360,GO:0009653,GO:0016021,GO:0016358,GO:0050672" Golgi membrane|cell morphogenesis|cytoplasm|Golgi apparatus|immune response|regulation of cell shape|anatomical structure morphogenesis|integral component of membrane|dendrite development|negative regulation of lymphocyte proliferation LTA 4.042768641 5.202069413 2.883467868 0.554292463 -0.851280704 0.745112452 1 0.121022181 0.065959162 4049 lymphotoxin alpha "GO:0001666,GO:0002876,GO:0002925,GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005615,GO:0005886,GO:0006915,GO:0006959,GO:0007165,GO:0007267,GO:0007584,GO:0032496,GO:0032729,GO:0033209,GO:0042493,GO:0043065,GO:0048147,GO:0048535,GO:0050830,GO:0060252" response to hypoxia|positive regulation of chronic inflammatory response to antigenic stimulus|positive regulation of humoral immune response mediated by circulating immunoglobulin|signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|extracellular space|plasma membrane|apoptotic process|humoral immune response|signal transduction|cell-cell signaling|response to nutrient|response to lipopolysaccharide|positive regulation of interferon-gamma production|tumor necrosis factor-mediated signaling pathway|response to drug|positive regulation of apoptotic process|negative regulation of fibroblast proliferation|lymph node development|defense response to Gram-positive bacterium|positive regulation of glial cell proliferation "hsa04060,hsa04061,hsa04064,hsa04668,hsa04940,hsa05166,hsa05168" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|NF-kappa B signaling pathway|TNF signaling pathway|Type I diabetes mellitus|Human T-cell leukemia virus 1 infection|Herpes simplex virus 1 infection LTA4H 6579.262511 6287.221093 6871.303929 1.0929 0.1281614 0.598792666 1 133.0441849 142.9708508 4048 leukotriene A4 hydrolase "GO:0003723,GO:0004177,GO:0004301,GO:0004463,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0006508,GO:0006691,GO:0008233,GO:0008270,GO:0019370,GO:0042759,GO:0043171,GO:0043312,GO:0044267,GO:0045148,GO:0070006,GO:0070062,GO:1904724,GO:1904813" RNA binding|aminopeptidase activity|epoxide hydrolase activity|leukotriene-A4 hydrolase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytosol|proteolysis|leukotriene metabolic process|peptidase activity|zinc ion binding|leukotriene biosynthetic process|long-chain fatty acid biosynthetic process|peptide catabolic process|neutrophil degranulation|cellular protein metabolic process|tripeptide aminopeptidase activity|metalloaminopeptidase activity|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen hsa00590 Arachidonic acid metabolism LTB4R 174.4882062 202.8807071 146.0957053 0.720106448 -0.47371791 0.216630251 1 2.345109478 1.660469872 1241 leukotriene B4 receptor "GO:0000166,GO:0001632,GO:0004974,GO:0005886,GO:0005887,GO:0006936,GO:0006954,GO:0006955,GO:0007186,GO:0007200,GO:0007218,GO:0008528,GO:0045121,GO:0061737" nucleotide binding|leukotriene B4 receptor activity|leukotriene receptor activity|plasma membrane|integral component of plasma membrane|muscle contraction|inflammatory response|immune response|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|G protein-coupled peptide receptor activity|membrane raft|leukotriene signaling pathway hsa04080 Neuroactive ligand-receptor interaction LTB4R2 23.69677594 29.13158871 18.26196316 0.626878381 -0.673742519 0.410330815 1 0.999164105 0.615873184 56413 leukotriene B4 receptor 2 "GO:0001632,GO:0004974,GO:0005654,GO:0005886,GO:0005887,GO:0006935,GO:0006954,GO:0007186,GO:0007194,GO:0007218,GO:0008528,GO:0016020,GO:0061737" leukotriene B4 receptor activity|leukotriene receptor activity|nucleoplasm|plasma membrane|integral component of plasma membrane|chemotaxis|inflammatory response|G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|neuropeptide signaling pathway|G protein-coupled peptide receptor activity|membrane|leukotriene signaling pathway "hsa04020,hsa04080" Calcium signaling pathway|Neuroactive ligand-receptor interaction LTBP1 462.9375599 445.2971418 480.577978 1.079229874 0.110002188 0.698267404 1 3.471831999 3.684205432 4052 latent transforming growth factor beta binding protein 1 "GO:0001527,GO:0005024,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005788,GO:0007178,GO:0031012,GO:0032991,GO:0035583,GO:0043687,GO:0044267,GO:0050431,GO:0050436,GO:0062023,GO:1901388" microfibril|transforming growth factor beta-activated receptor activity|extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|endoplasmic reticulum lumen|transmembrane receptor protein serine/threonine kinase signaling pathway|extracellular matrix|protein-containing complex|sequestering of TGFbeta in extracellular matrix|post-translational protein modification|cellular protein metabolic process|transforming growth factor beta binding|microfibril binding|collagen-containing extracellular matrix|regulation of transforming growth factor beta activation hsa04350 TGF-beta signaling pathway LTBP2 2267.783043 2446.013038 2089.553048 0.854268974 -0.227237709 0.336531286 1 15.43016788 12.9609389 4053 latent transforming growth factor beta binding protein 2 "GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0006605,GO:0007179,GO:0008201,GO:0009306,GO:0019838,GO:0031012,GO:0050436,GO:0062023,GO:0070062,GO:0097435" extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|extracellular space|protein targeting|transforming growth factor beta receptor signaling pathway|heparin binding|protein secretion|growth factor binding|extracellular matrix|microfibril binding|collagen-containing extracellular matrix|extracellular exosome|supramolecular fiber organization LTBP3 2321.696481 2524.044079 2119.348883 0.839663974 -0.252116005 0.286207145 1 25.4301668 20.99548481 4054 latent transforming growth factor beta binding protein 3 "GO:0005509,GO:0005515,GO:0005576,GO:0007179,GO:0030502,GO:0032331,GO:0036363,GO:0045780,GO:0046849,GO:0048251,GO:0050431,GO:0060349,GO:0060430,GO:0062023,GO:0070062,GO:1902462,GO:2000741" calcium ion binding|protein binding|extracellular region|transforming growth factor beta receptor signaling pathway|negative regulation of bone mineralization|negative regulation of chondrocyte differentiation|transforming growth factor beta activation|positive regulation of bone resorption|bone remodeling|elastic fiber assembly|transforming growth factor beta binding|bone morphogenesis|lung saccule development|collagen-containing extracellular matrix|extracellular exosome|positive regulation of mesenchymal stem cell proliferation|positive regulation of mesenchymal stem cell differentiation LTBP4 3072.701582 3264.818764 2880.5844 0.882310661 -0.180641378 0.445805507 1 31.98776885 27.75087328 8425 latent transforming growth factor beta binding protein 4 "GO:0001527,GO:0001558,GO:0005024,GO:0005178,GO:0005201,GO:0005509,GO:0005515,GO:0005539,GO:0005576,GO:0005615,GO:0006457,GO:0007179,GO:0007275,GO:0017015,GO:0030162,GO:0030252,GO:0031012,GO:0045595,GO:0050431,GO:0062023" microfibril|regulation of cell growth|transforming growth factor beta-activated receptor activity|integrin binding|extracellular matrix structural constituent|calcium ion binding|protein binding|glycosaminoglycan binding|extracellular region|extracellular space|protein folding|transforming growth factor beta receptor signaling pathway|multicellular organism development|regulation of transforming growth factor beta receptor signaling pathway|regulation of proteolysis|growth hormone secretion|extracellular matrix|regulation of cell differentiation|transforming growth factor beta binding|collagen-containing extracellular matrix LTBR 2613.945799 2777.905067 2449.986532 0.881954737 -0.181223478 0.443683065 1 54.00790085 46.8354582 4055 lymphotoxin beta receptor "GO:0005515,GO:0005794,GO:0005886,GO:0006915,GO:0006955,GO:0007165,GO:0016021,GO:0016032,GO:0031625,GO:0033209,GO:0042802,GO:0043011,GO:0043123,GO:0046330,GO:0071260,GO:2001238" protein binding|Golgi apparatus|plasma membrane|apoptotic process|immune response|signal transduction|integral component of membrane|viral process|ubiquitin protein ligase binding|tumor necrosis factor-mediated signaling pathway|identical protein binding|myeloid dendritic cell differentiation|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of JNK cascade|cellular response to mechanical stimulus|positive regulation of extrinsic apoptotic signaling pathway "hsa04060,hsa04061,hsa04064,hsa04066,hsa04672,hsa05166,hsa05203" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|NF-kappa B signaling pathway|HIF-1 signaling pathway|Intestinal immune network for IgA production|Human T-cell leukemia virus 1 infection|Viral carcinogenesis LTN1 1618.279275 1657.379315 1579.179236 0.952817029 -0.069728896 0.771421529 1 10.48249442 9.820765227 26046 listerin E3 ubiquitin protein ligase 1 "GO:0005515,GO:0005829,GO:0008270,GO:0043023,GO:0051865,GO:0061630,GO:0072344,GO:1990112,GO:1990116" protein binding|cytosol|zinc ion binding|ribosomal large subunit binding|protein autoubiquitination|ubiquitin protein ligase activity|rescue of stalled ribosome|RQC complex|ribosome-associated ubiquitin-dependent protein catabolic process LTO1 363.6862458 375.5894116 351.7830799 0.936616073 -0.094470299 0.757798701 1 8.069451125 7.431505106 220064 LTO1 maturation factor of ABCE1 "GO:0000723,GO:0003674,GO:0005515,GO:0005575,GO:0005634,GO:0006413,GO:0042273,GO:0106035" telomere maintenance|molecular_function|protein binding|cellular_component|nucleus|translational initiation|ribosomal large subunit biogenesis|protein maturation by [4Fe-4S] cluster transfer LTV1 443.4269772 462.9841778 423.8697766 0.915516765 -0.12734179 0.655966108 1 13.33438459 12.00357076 84946 LTV1 ribosome biogenesis factor "GO:0000056,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0030688,GO:0042274" "ribosomal small subunit export from nucleus|protein binding|nucleus|nucleoplasm|cytosol|preribosome, small subunit precursor|ribosomal small subunit biogenesis" LUC7L 431.536445 453.6204528 409.4524373 0.902632222 -0.147789814 0.606533313 1 9.232986212 8.194532809 55692 LUC7 like "GO:0003729,GO:0005515,GO:0005685,GO:0006376,GO:0042802,GO:0071004" mRNA binding|protein binding|U1 snRNP|mRNA splice site selection|identical protein binding|U2-type prespliceosome LUC7L2 64.45155489 64.50566072 64.39744905 0.998322447 -0.00242223 1 1 1.205796342 1.183630034 51631 "LUC7 like 2, pre-mRNA splicing factor" "GO:0003723,GO:0003729,GO:0005515,GO:0005685,GO:0006376,GO:0016607,GO:0019899,GO:0071004" RNA binding|mRNA binding|protein binding|U1 snRNP|mRNA splice site selection|nuclear speck|enzyme binding|U2-type prespliceosome LUC7L3 2692.513982 2594.792223 2790.23574 1.075321452 0.104767997 0.658587924 1 37.92914049 40.10351963 51747 LUC7 like 3 pre-mRNA splicing factor "GO:0003677,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005685,GO:0006376,GO:0008380,GO:0016607,GO:0071004" DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|U1 snRNP|mRNA splice site selection|RNA splicing|nuclear speck|U2-type prespliceosome LUM 9.928591267 8.323311061 11.53387147 1.385731158 0.470647391 0.750315201 1 0.166304685 0.226597255 4060 lumican "GO:0005201,GO:0005515,GO:0005518,GO:0005576,GO:0005583,GO:0005615,GO:0005796,GO:0007601,GO:0014070,GO:0018146,GO:0030021,GO:0030198,GO:0030199,GO:0031012,GO:0032914,GO:0042340,GO:0043202,GO:0045944,GO:0051216,GO:0062023,GO:0070062,GO:0070848" extracellular matrix structural constituent|protein binding|collagen binding|extracellular region|fibrillar collagen trimer|extracellular space|Golgi lumen|visual perception|response to organic cyclic compound|keratan sulfate biosynthetic process|extracellular matrix structural constituent conferring compression resistance|extracellular matrix organization|collagen fibril organization|extracellular matrix|positive regulation of transforming growth factor beta1 production|keratan sulfate catabolic process|lysosomal lumen|positive regulation of transcription by RNA polymerase II|cartilage development|collagen-containing extracellular matrix|extracellular exosome|response to growth factor hsa05205 Proteoglycans in cancer LURAP1 146.8033819 132.1325631 161.4742006 1.222062123 0.289317626 0.485639335 1 3.813776118 4.582681318 541468 leucine rich adaptor protein 1 "GO:0001819,GO:0005515,GO:0005737,GO:0005829,GO:0016477,GO:0031032,GO:0042641,GO:0043123,GO:0043231" positive regulation of cytokine production|protein binding|cytoplasm|cytosol|cell migration|actomyosin structure organization|actomyosin|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle LURAP1L 301.7810054 352.7003062 250.8617045 0.71126024 -0.491550576 0.117262683 1 6.095520436 4.262952586 286343 leucine rich adaptor protein 1 like "GO:0005515,GO:0043123" protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling LUZP1 1651.102002 1698.99587 1603.208135 0.943620972 -0.083720612 0.726439102 1 10.19935737 9.463277424 7798 leucine zipper protein 1 "GO:0003281,GO:0005634,GO:0016020,GO:0021503,GO:0060840,GO:0070062" ventricular septum development|nucleus|membrane|neural fold bending|artery development|extracellular exosome LUZP2 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.017626977 0.010674449 338645 leucine zipper protein 2 GO:0005576 extracellular region LVRN 10.16636505 14.56579436 5.766935736 0.395923188 -1.336707531 0.252942837 1 0.16884224 0.065729938 206338 laeverin "GO:0005737,GO:0005886,GO:0006508,GO:0007165,GO:0008217,GO:0008270,GO:0016021,GO:0042277,GO:0043171,GO:0070006" cytoplasm|plasma membrane|proteolysis|signal transduction|regulation of blood pressure|zinc ion binding|integral component of membrane|peptide binding|peptide catabolic process|metalloaminopeptidase activity LXN 221.4565147 123.809252 319.1037774 2.577382321 1.365906558 0.000123241 0.04393817 6.169441857 15.6349285 56925 latexin "GO:0005515,GO:0005615,GO:0005737,GO:0006954,GO:0008191,GO:0008201,GO:0010951,GO:0050965" protein binding|extracellular space|cytoplasm|inflammatory response|metalloendopeptidase inhibitor activity|heparin binding|negative regulation of endopeptidase activity|detection of temperature stimulus involved in sensory perception of pain LY6E 835.4025426 899.9580085 770.8470767 0.856536716 -0.223413006 0.373013293 1 42.46605204 35.76506758 4061 lymphocyte antigen 6 family member E "GO:0005515,GO:0005576,GO:0005886,GO:0007166,GO:0030550,GO:0031225,GO:0046597,GO:2000272" protein binding|extracellular region|plasma membrane|cell surface receptor signaling pathway|acetylcholine receptor inhibitor activity|anchored component of membrane|negative regulation of viral entry into host cell|negative regulation of signaling receptor activity LY6G5B 70.77832653 66.58648849 74.97016457 1.125906566 0.171087109 0.767990387 1 4.591212545 5.082775509 58496 lymphocyte antigen 6 family member G5B "GO:0005576,GO:0009897,GO:0032991,GO:0042802" extracellular region|external side of plasma membrane|protein-containing complex|identical protein binding LY6G5C 7.486072413 7.282897178 7.689247648 1.055795168 0.078329968 1 1 0.535364789 0.555777106 80741 lymphocyte antigen 6 family member G5C "GO:0005576,GO:0009897,GO:0032991,GO:0042802" extracellular region|external side of plasma membrane|protein-containing complex|identical protein binding LY6K 2229.682061 1887.310783 2572.053338 1.362813884 0.44658855 0.05904722 1 30.59608377 40.99902881 54742 lymphocyte antigen 6 family member K "GO:0001669,GO:0005576,GO:0005886,GO:0007339,GO:0031225,GO:0045121" acrosomal vesicle|extracellular region|plasma membrane|binding of sperm to zona pellucida|anchored component of membrane|membrane raft LY96 137.0232456 152.9408407 121.1056505 0.791846376 -0.336707531 0.426653329 1 6.44212437 5.015811616 23643 lymphocyte antigen 96 "GO:0001530,GO:0001875,GO:0002224,GO:0002755,GO:0002756,GO:0005515,GO:0005615,GO:0005886,GO:0006954,GO:0006968,GO:0007166,GO:0007249,GO:0010008,GO:0015026,GO:0031226,GO:0031663,GO:0031666,GO:0032496,GO:0032497,GO:0032760,GO:0034128,GO:0034142,GO:0035662,GO:0035666,GO:0045087,GO:0046696,GO:0070266,GO:0071222,GO:0097190" lipopolysaccharide binding|lipopolysaccharide immune receptor activity|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|protein binding|extracellular space|plasma membrane|inflammatory response|cellular defense response|cell surface receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|endosome membrane|coreceptor activity|intrinsic component of plasma membrane|lipopolysaccharide-mediated signaling pathway|positive regulation of lipopolysaccharide-mediated signaling pathway|response to lipopolysaccharide|detection of lipopolysaccharide|positive regulation of tumor necrosis factor production|negative regulation of MyD88-independent toll-like receptor signaling pathway|toll-like receptor 4 signaling pathway|Toll-like receptor 4 binding|TRIF-dependent toll-like receptor signaling pathway|innate immune response|lipopolysaccharide receptor complex|necroptotic process|cellular response to lipopolysaccharide|apoptotic signaling pathway "hsa04064,hsa04620,hsa05132,hsa05133,hsa05145" NF-kappa B signaling pathway|Toll-like receptor signaling pathway|Salmonella infection|Pertussis|Toxoplasmosis LYAR 456.5761897 429.6909335 483.4614459 1.125137647 0.170101508 0.546303967 1 11.5409237 12.7678392 55646 Ly1 antibody reactive "GO:0000122,GO:0001750,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0033613,GO:0042802,GO:0045087,GO:0045824,GO:0045943,GO:0046872,GO:0048821,GO:0050766,GO:0140416" negative regulation of transcription by RNA polymerase II|photoreceptor outer segment|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|rRNA processing|activating transcription factor binding|identical protein binding|innate immune response|negative regulation of innate immune response|positive regulation of transcription by RNA polymerase I|metal ion binding|erythrocyte development|positive regulation of phagocytosis|transcription regulator inhibitor activity LYG1 7.927021428 6.242483296 9.61155956 1.539701286 0.622650484 0.695278173 1 0.137494783 0.208158367 129530 lysozyme g1 "GO:0003796,GO:0005515,GO:0005576,GO:0009253,GO:0016998,GO:0050830" lysozyme activity|protein binding|extracellular region|peptidoglycan catabolic process|cell wall macromolecule catabolic process|defense response to Gram-positive bacterium LYL1 64.5754722 55.14193578 74.00900861 1.342154706 0.424550976 0.446402922 1 1.987051834 2.622303492 4066 LYL1 basic helix-loop-helix family member "GO:0000785,GO:0000978,GO:0000981,GO:0001955,GO:0003677,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0030183,GO:0045893,GO:0046983,GO:0060216" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|blood vessel maturation|DNA binding|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|B cell differentiation|positive regulation of transcription, DNA-templated|protein dimerization activity|definitive hemopoiesis" hsa05202 Transcriptional misregulation in cancer bHLH LYN 1178.66674 1269.304937 1088.028542 0.857184519 -0.2223223 0.359672291 1 9.235238118 7.783834535 4067 "LYN proto-oncogene, Src family tyrosine kinase" "GO:0001782,GO:0001817,GO:0001932,GO:0001933,GO:0001934,GO:0002223,GO:0002250,GO:0002431,GO:0002513,GO:0002553,GO:0002576,GO:0002762,GO:0002768,GO:0002774,GO:0002902,GO:0004713,GO:0004715,GO:0005102,GO:0005161,GO:0005178,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005758,GO:0005794,GO:0005829,GO:0005886,GO:0005912,GO:0006468,GO:0006974,GO:0006991,GO:0007165,GO:0007169,GO:0007596,GO:0008284,GO:0008285,GO:0009636,GO:0009725,GO:0009743,GO:0010976,GO:0014003,GO:0014068,GO:0014069,GO:0014070,GO:0016032,GO:0016301,GO:0017124,GO:0018108,GO:0030061,GO:0030154,GO:0030168,GO:0030218,GO:0030335,GO:0030889,GO:0031175,GO:0031234,GO:0031295,GO:0031625,GO:0031663,GO:0031668,GO:0032868,GO:0033003,GO:0033628,GO:0034136,GO:0034142,GO:0034144,GO:0034605,GO:0034666,GO:0035556,GO:0038083,GO:0038095,GO:0038096,GO:0042127,GO:0042493,GO:0042531,GO:0043015,GO:0043200,GO:0043208,GO:0043231,GO:0043304,GO:0043407,GO:0043552,GO:0044325,GO:0045087,GO:0045121,GO:0045646,GO:0046579,GO:0046777,GO:0046875,GO:0048013,GO:0048471,GO:0048678,GO:0050727,GO:0050777,GO:0050853,GO:0050855,GO:0050900,GO:0051219,GO:0051272,GO:0051279,GO:0060252,GO:0060369,GO:0060397,GO:0070062,GO:0070304,GO:0070372,GO:0070373,GO:0070447,GO:0070667,GO:0070668,GO:0071300,GO:0090025,GO:0090330,GO:0097028,GO:0098978,GO:0099091,GO:0140031,GO:1902532,GO:1902961,GO:2000670" "B cell homeostasis|regulation of cytokine production|regulation of protein phosphorylation|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|stimulatory C-type lectin receptor signaling pathway|adaptive immune response|Fc receptor mediated stimulatory signaling pathway|tolerance induction to self antigen|histamine secretion by mast cell|platelet degranulation|negative regulation of myeloid leukocyte differentiation|immune response-regulating cell surface receptor signaling pathway|Fc receptor mediated inhibitory signaling pathway|regulation of B cell apoptotic process|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|platelet-derived growth factor receptor binding|integrin binding|protein binding|ATP binding|nucleus|cytoplasm|mitochondrial intermembrane space|Golgi apparatus|cytosol|plasma membrane|adherens junction|protein phosphorylation|cellular response to DNA damage stimulus|response to sterol depletion|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|blood coagulation|positive regulation of cell population proliferation|negative regulation of cell population proliferation|response to toxic substance|response to hormone|response to carbohydrate|positive regulation of neuron projection development|oligodendrocyte development|positive regulation of phosphatidylinositol 3-kinase signaling|postsynaptic density|response to organic cyclic compound|viral process|kinase activity|SH3 domain binding|peptidyl-tyrosine phosphorylation|mitochondrial crista|cell differentiation|platelet activation|erythrocyte differentiation|positive regulation of cell migration|negative regulation of B cell proliferation|neuron projection development|extrinsic component of cytoplasmic side of plasma membrane|T cell costimulation|ubiquitin protein ligase binding|lipopolysaccharide-mediated signaling pathway|cellular response to extracellular stimulus|response to insulin|regulation of mast cell activation|regulation of cell adhesion mediated by integrin|negative regulation of toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway|negative regulation of toll-like receptor 4 signaling pathway|cellular response to heat|integrin alpha2-beta1 complex|intracellular signal transduction|peptidyl-tyrosine autophosphorylation|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of cell population proliferation|response to drug|positive regulation of tyrosine phosphorylation of STAT protein|gamma-tubulin binding|response to amino acid|glycosphingolipid binding|intracellular membrane-bounded organelle|regulation of mast cell degranulation|negative regulation of MAP kinase activity|positive regulation of phosphatidylinositol 3-kinase activity|ion channel binding|innate immune response|membrane raft|regulation of erythrocyte differentiation|positive regulation of Ras protein signal transduction|protein autophosphorylation|ephrin receptor binding|ephrin receptor signaling pathway|perinuclear region of cytoplasm|response to axon injury|regulation of inflammatory response|negative regulation of immune response|B cell receptor signaling pathway|regulation of B cell receptor signaling pathway|leukocyte migration|phosphoprotein binding|positive regulation of cellular component movement|regulation of release of sequestered calcium ion into cytosol|positive regulation of glial cell proliferation|positive regulation of Fc receptor mediated stimulatory signaling pathway|growth hormone receptor signaling pathway via JAK-STAT|extracellular exosome|positive regulation of stress-activated protein kinase signaling cascade|regulation of ERK1 and ERK2 cascade|negative regulation of ERK1 and ERK2 cascade|positive regulation of oligodendrocyte progenitor proliferation|negative regulation of mast cell proliferation|positive regulation of mast cell proliferation|cellular response to retinoic acid|regulation of monocyte chemotaxis|regulation of platelet aggregation|dendritic cell differentiation|glutamatergic synapse|postsynaptic specialization, intracellular component|phosphorylation-dependent protein binding|negative regulation of intracellular signal transduction|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of dendritic cell apoptotic process" "hsa04062,hsa04064,hsa04611,hsa04662,hsa04664,hsa04666,hsa04730,hsa05120,hsa05167,hsa05169,hsa05203" Chemokine signaling pathway|NF-kappa B signaling pathway|Platelet activation|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Long-term depression|Epithelial cell signaling in Helicobacter pylori infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Viral carcinogenesis LYPD1 10.24562297 16.64662212 3.844623824 0.230955193 -2.11431511 0.07437154 1 0.222099907 0.050436772 116372 LY6/PLAUR domain containing 1 "GO:0005576,GO:0005886,GO:0030550,GO:0031225,GO:0045202,GO:0095500,GO:2000272" extracellular region|plasma membrane|acetylcholine receptor inhibitor activity|anchored component of membrane|synapse|acetylcholine receptor signaling pathway|negative regulation of signaling receptor activity LYPD3 328.3568331 293.3967149 363.3169514 1.238312949 0.308375962 0.315288908 1 9.535958243 11.61090131 27076 LY6/PLAUR domain containing 3 "GO:0005576,GO:0005615,GO:0005886,GO:0007160,GO:0016021,GO:0043236,GO:0046658" extracellular region|extracellular space|plasma membrane|cell-matrix adhesion|integral component of membrane|laminin binding|anchored component of plasma membrane LYPD5 8.967435311 8.323311061 9.61155956 1.154775965 0.207612985 0.965671908 1 0.171241254 0.194436285 284348 LY6/PLAUR domain containing 5 "GO:0005515,GO:0005576,GO:0005886,GO:0007160,GO:0031225,GO:0043236" protein binding|extracellular region|plasma membrane|cell-matrix adhesion|anchored component of membrane|laminin binding LYPD6 1011.254454 898.9175946 1123.591313 1.249938058 0.321856602 0.190115066 1 6.829951578 8.394161004 130574 LY6/PLAUR domain containing 6 "GO:0005515,GO:0005576,GO:0005737,GO:0005886,GO:0030548,GO:0030550,GO:0031225,GO:0043005,GO:0045121,GO:0045202,GO:0090263,GO:0099601,GO:2000272" protein binding|extracellular region|cytoplasm|plasma membrane|acetylcholine receptor regulator activity|acetylcholine receptor inhibitor activity|anchored component of membrane|neuron projection|membrane raft|synapse|positive regulation of canonical Wnt signaling pathway|regulation of neurotransmitter receptor activity|negative regulation of signaling receptor activity LYPD6B 6.123596406 9.363724944 2.883467868 0.307940257 -1.699277611 0.271781165 1 0.257722945 0.078035233 130576 LY6/PLAUR domain containing 6B "GO:0005576,GO:0005886,GO:0030548,GO:0031225,GO:0099601" extracellular region|plasma membrane|acetylcholine receptor regulator activity|anchored component of membrane|regulation of neurotransmitter receptor activity LYPLA1 3983.381874 4097.14987 3869.613879 0.944464811 -0.082431049 0.729848277 1 81.649499 75.82466226 10434 lysophospholipase 1 "GO:0002084,GO:0004620,GO:0004622,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0006631,GO:0008474,GO:0016298,GO:0018215,GO:0031965,GO:0042997,GO:0050999,GO:0052689,GO:0070062" protein depalmitoylation|phospholipase activity|lysophospholipase activity|protein binding|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|fatty acid metabolic process|palmitoyl-(protein) hydrolase activity|lipase activity|protein phosphopantetheinylation|nuclear membrane|negative regulation of Golgi to plasma membrane protein transport|regulation of nitric-oxide synthase activity|carboxylic ester hydrolase activity|extracellular exosome "hsa00564,hsa05231" Glycerophospholipid metabolism|Choline metabolism in cancer LYPLA2 1123.798405 976.9486358 1270.648174 1.300629457 0.379210004 0.119273322 1 24.87497764 31.81174287 11313 lysophospholipase 2 "GO:0002084,GO:0004622,GO:0005515,GO:0005737,GO:0005795,GO:0005829,GO:0006631,GO:0007411,GO:0008474,GO:0018215,GO:0045296,GO:0046464,GO:0052689,GO:0070062,GO:1905344" protein depalmitoylation|lysophospholipase activity|protein binding|cytoplasm|Golgi stack|cytosol|fatty acid metabolic process|axon guidance|palmitoyl-(protein) hydrolase activity|protein phosphopantetheinylation|cadherin binding|acylglycerol catabolic process|carboxylic ester hydrolase activity|extracellular exosome|prostaglandin catabolic process hsa00564 Glycerophospholipid metabolism LYPLAL1 402.6030011 400.5593448 404.6466575 1.010204013 0.014646678 0.969133238 1 2.746289316 2.727888125 127018 lysophospholipase like 1 "GO:0002084,GO:0004622,GO:0005515,GO:0005737,GO:0005829,GO:0008150,GO:0008474,GO:0018215,GO:0052689" protein depalmitoylation|lysophospholipase activity|protein binding|cytoplasm|cytosol|biological_process|palmitoyl-(protein) hydrolase activity|protein phosphopantetheinylation|carboxylic ester hydrolase activity LYRM1 249.8395692 250.7397457 248.9393926 0.992819834 -0.010396158 0.988818155 1 4.571752439 4.462973707 57149 LYR motif containing 1 "GO:0005654,GO:0030496" nucleoplasm|midbody LYRM2 441.1480046 453.6204528 428.6755564 0.945009322 -0.081599535 0.778802198 1 4.527564961 4.206994665 57226 LYR motif containing 2 GO:0005515 protein binding LYRM4 477.5775817 488.9945248 466.1606387 0.953304413 -0.068991119 0.809443375 1 3.63565604 3.407890024 57128 LYR motif containing 4 "GO:0005515,GO:0005739,GO:0005759,GO:0016226,GO:0016604,GO:0044281,GO:1990221" protein binding|mitochondrion|mitochondrial matrix|iron-sulfur cluster assembly|nuclear body|small molecule metabolic process|L-cysteine desulfurase complex LYRM7 344.2253529 369.3469283 319.1037774 0.863967595 -0.210950893 0.488100726 1 3.169539594 2.692556428 90624 LYR motif containing 7 "GO:0005515,GO:0005759,GO:0031966,GO:0034551,GO:0045333" protein binding|mitochondrial matrix|mitochondrial membrane|mitochondrial respiratory chain complex III assembly|cellular respiration LYRM9 70.41663544 69.70773014 71.12554074 1.02033936 0.029049065 0.986800928 1 0.641409214 0.643503647 201229 LYR motif containing 9 LYSMD1 190.9071154 204.9615349 176.8526959 0.86285798 -0.212804973 0.572194969 1 4.442900249 3.769441964 388695 LysM domain containing 1 "GO:0005515,GO:0005654" protein binding|nucleoplasm LYSMD2 134.6700455 129.0113214 140.3287696 1.087724457 0.121313139 0.78863031 1 4.354900135 4.657665253 256586 LysM domain containing 2 LYSMD3 1203.181861 1155.899824 1250.463899 1.081809923 0.113447035 0.64131794 1 13.05019021 13.88158258 116068 LysM domain containing 3 "GO:0005794,GO:0005886,GO:0007030,GO:0016021" Golgi apparatus|plasma membrane|Golgi organization|integral component of membrane LYSMD4 202.2082435 186.234085 218.182402 1.171549247 0.2284176 0.534274423 1 1.256348228 1.447244005 145748 LysM domain containing 4 GO:0016021 integral component of membrane LYST 769.6728 827.1290367 712.2165634 0.861070682 -0.215796428 0.394485107 1 2.630026006 2.226742631 1130 lysosomal trafficking regulator "GO:0005515,GO:0005829,GO:0006909,GO:0007040,GO:0008104,GO:0015031,GO:0015630,GO:0016020,GO:0019901,GO:0030595,GO:0032438,GO:0032510,GO:0033364,GO:0042267,GO:0042742,GO:0042832,GO:0043473,GO:0051607" protein binding|cytosol|phagocytosis|lysosome organization|protein localization|protein transport|microtubule cytoskeleton|membrane|protein kinase binding|leukocyte chemotaxis|melanosome organization|endosome to lysosome transport via multivesicular body sorting pathway|mast cell secretory granule organization|natural killer cell mediated cytotoxicity|defense response to bacterium|defense response to protozoan|pigmentation|defense response to virus LZIC 551.1104284 577.4297049 524.791152 0.908839894 -0.13790193 0.60990098 1 5.909177771 5.280628516 84328 leucine zipper and CTNNBIP1 domain containing "GO:0005515,GO:0008013,GO:0010212" protein binding|beta-catenin binding|response to ionizing radiation LZTFL1 520.1458466 496.277422 544.0142711 1.096189847 0.132497677 0.628974027 1 5.379933759 5.798743278 54585 leucine zipper transcription factor like 1 "GO:0005515,GO:0005737,GO:0005829,GO:0042802,GO:0044877,GO:1903565,GO:1903568" protein binding|cytoplasm|cytosol|identical protein binding|protein-containing complex binding|negative regulation of protein localization to cilium|negative regulation of protein localization to ciliary membrane LZTR1 814.6936445 810.4824146 818.9048745 1.01039191 0.014914992 0.957996551 1 10.10134443 10.0355278 8216 leucine zipper like transcription regulator 1 "GO:0005515,GO:0005794,GO:0012505,GO:0016567,GO:0031267,GO:0031463,GO:0046580,GO:0055038" protein binding|Golgi apparatus|endomembrane system|protein ubiquitination|small GTPase binding|Cul3-RING ubiquitin ligase complex|negative regulation of Ras protein signal transduction|recycling endosome membrane LZTS2 3805.728381 3798.551086 3812.905677 1.003778965 0.005441619 0.982990088 1 56.81661715 56.07698317 84445 leucine zipper tumor suppressor 2 "GO:0000281,GO:0005515,GO:0005813,GO:0005829,GO:0005874,GO:0005886,GO:0008285,GO:0016055,GO:0030496,GO:0031982,GO:0051013,GO:0051168,GO:0051255,GO:0060682,GO:0072197,GO:0090090,GO:1900181" mitotic cytokinesis|protein binding|centrosome|cytosol|microtubule|plasma membrane|negative regulation of cell population proliferation|Wnt signaling pathway|midbody|vesicle|microtubule severing|nuclear export|spindle midzone assembly|primary ureteric bud growth|ureter morphogenesis|negative regulation of canonical Wnt signaling pathway|negative regulation of protein localization to nucleus LZTS3 451.5672347 436.9738307 466.1606387 1.066793034 0.093280309 0.745351202 1 3.846996077 4.035274595 9762 leucine zipper tumor suppressor family member 3 "GO:0005737,GO:0005856,GO:0014069,GO:0043197,GO:0045202,GO:0061001" cytoplasm|cytoskeleton|postsynaptic density|dendritic spine|synapse|regulation of dendritic spine morphogenesis M6PR 2808.876176 2937.088391 2680.663961 0.912694344 -0.131796304 0.578000915 1 60.61369268 54.39603949 4074 "mannose-6-phosphate receptor, cation dependent" "GO:0004888,GO:0005515,GO:0005765,GO:0005768,GO:0005770,GO:0005802,GO:0005886,GO:0005887,GO:0006622,GO:0006898,GO:0007041,GO:0008333,GO:0016020,GO:0019904,GO:0030133,GO:0030665,GO:0032588,GO:0033299,GO:0048471,GO:0061024,GO:1905394" transmembrane signaling receptor activity|protein binding|lysosomal membrane|endosome|late endosome|trans-Golgi network|plasma membrane|integral component of plasma membrane|protein targeting to lysosome|receptor-mediated endocytosis|lysosomal transport|endosome to lysosome transport|membrane|protein domain specific binding|transport vesicle|clathrin-coated vesicle membrane|trans-Golgi network membrane|secretion of lysosomal enzymes|perinuclear region of cytoplasm|membrane organization|retromer complex binding "hsa04142,hsa04145,hsa05132" Lysosome|Phagosome|Salmonella infection MAB21L3 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.043893262 0.059806449 126868 mab-21 like 3 GO:0005515 protein binding MACF1 7689.118011 8273.371195 7104.864827 0.858762971 -0.21966811 0.371891682 1 24.96097093 21.07686253 23499 microtubule actin crosslinking factor 1 "GO:0003723,GO:0003779,GO:0005198,GO:0005509,GO:0005515,GO:0005737,GO:0005794,GO:0005856,GO:0005874,GO:0005882,GO:0005886,GO:0010632,GO:0015629,GO:0016020,GO:0016055,GO:0016887,GO:0030177,GO:0030334,GO:0032587,GO:0032886,GO:0042060,GO:0043001,GO:0045104,GO:0045296,GO:0045773,GO:0051011,GO:0051015,GO:0051893,GO:0150011" RNA binding|actin binding|structural molecule activity|calcium ion binding|protein binding|cytoplasm|Golgi apparatus|cytoskeleton|microtubule|intermediate filament|plasma membrane|regulation of epithelial cell migration|actin cytoskeleton|membrane|Wnt signaling pathway|ATPase activity|positive regulation of Wnt signaling pathway|regulation of cell migration|ruffle membrane|regulation of microtubule-based process|wound healing|Golgi to plasma membrane protein transport|intermediate filament cytoskeleton organization|cadherin binding|positive regulation of axon extension|microtubule minus-end binding|actin filament binding|regulation of focal adhesion assembly|regulation of neuron projection arborization MACIR 587.6645373 502.5199053 672.8091692 1.338870684 0.421016623 0.110815358 1 7.505895257 9.881259629 90355 macrophage immunometabolism regulator "GO:0005515,GO:0005737,GO:0006954,GO:0010764,GO:0015031,GO:0035869,GO:0050728,GO:0060271,GO:1900016" protein binding|cytoplasm|inflammatory response|negative regulation of fibroblast migration|protein transport|ciliary transition zone|negative regulation of inflammatory response|cilium assembly|negative regulation of cytokine production involved in inflammatory response MACO1 335.8278143 338.1345119 333.5211167 0.986356332 -0.019819165 0.95875544 1 5.438703265 5.274731769 55219 macoilin 1 "GO:0003674,GO:0005515,GO:0005634,GO:0006935,GO:0007420,GO:0008017,GO:0016021,GO:0023041,GO:0030424,GO:0030867,GO:0031965,GO:0044306,GO:0045202,GO:0051015" molecular_function|protein binding|nucleus|chemotaxis|brain development|microtubule binding|integral component of membrane|neuronal signal transduction|axon|rough endoplasmic reticulum membrane|nuclear membrane|neuron projection terminus|synapse|actin filament binding MACROD1 200.1123245 219.5273292 180.6973197 0.823119929 -0.280825447 0.443766618 1 3.239980666 2.62226582 28992 mono-ADP ribosylhydrolase 1 "GO:0005515,GO:0005634,GO:0005654,GO:0006974,GO:0016798,GO:0019213,GO:0042278,GO:0051725,GO:0140291,GO:0140293" "protein binding|nucleus|nucleoplasm|cellular response to DNA damage stimulus|hydrolase activity, acting on glycosyl bonds|deacetylase activity|purine nucleoside metabolic process|protein de-ADP-ribosylation|peptidyl-glutamate ADP-deribosylation|ADP-ribosylglutamate hydrolase activity" MACROD2 26.98156386 27.05076095 26.91236677 0.994883908 -0.007399906 1 1 0.272798449 0.266861229 140733 mono-ADP ribosylhydrolase 2 "GO:0005634,GO:0005654,GO:0005730,GO:0006974,GO:0016798,GO:0019213,GO:0042278,GO:0051725,GO:0140291,GO:0140293" "nucleus|nucleoplasm|nucleolus|cellular response to DNA damage stimulus|hydrolase activity, acting on glycosyl bonds|deacetylase activity|purine nucleoside metabolic process|protein de-ADP-ribosylation|peptidyl-glutamate ADP-deribosylation|ADP-ribosylglutamate hydrolase activity" MACROH2A1 4400.368845 4282.343541 4518.394149 1.055121829 0.077409588 0.746498249 1 17.93743067 18.60947075 9555 macroH2A.1 histone "GO:0000122,GO:0000182,GO:0000228,GO:0000781,GO:0000785,GO:0000786,GO:0000793,GO:0000976,GO:0000977,GO:0000979,GO:0001739,GO:0001740,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005721,GO:0005730,GO:0006334,GO:0006342,GO:0007549,GO:0010385,GO:0019216,GO:0019899,GO:0019901,GO:0030291,GO:0031490,GO:0031492,GO:0033128,GO:0034184,GO:0040029,GO:0045618,GO:0045814,GO:0045815,GO:0046982,GO:0051572,GO:0061086,GO:0061187,GO:0070062,GO:0071169,GO:0071901,GO:1901837,GO:1902750,GO:1902882,GO:1903226,GO:1904815,GO:1990841" "negative regulation of transcription by RNA polymerase II|rDNA binding|nuclear chromosome|chromosome, telomeric region|chromatin|nucleosome|condensed chromosome|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|sex chromatin|Barr body|DNA binding|protein binding|nucleus|nucleoplasm|pericentric heterochromatin|nucleolus|nucleosome assembly|chromatin silencing|dosage compensation|double-stranded methylated DNA binding|regulation of lipid metabolic process|enzyme binding|protein kinase binding|protein serine/threonine kinase inhibitor activity|chromatin DNA binding|nucleosomal DNA binding|negative regulation of histone phosphorylation|positive regulation of maintenance of mitotic sister chromatid cohesion|regulation of gene expression, epigenetic|positive regulation of keratinocyte differentiation|negative regulation of gene expression, epigenetic|positive regulation of gene expression, epigenetic|protein heterodimerization activity|negative regulation of histone H3-K4 methylation|negative regulation of histone H3-K27 methylation|regulation of ribosomal DNA heterochromatin assembly|extracellular exosome|establishment of protein localization to chromatin|negative regulation of protein serine/threonine kinase activity|negative regulation of transcription of nucleolar large rRNA by RNA polymerase I|negative regulation of cell cycle G2/M phase transition|regulation of response to oxidative stress|positive regulation of endodermal cell differentiation|negative regulation of protein localization to chromosome, telomeric region|promoter-specific chromatin binding" "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus MACROH2A2 31.50491048 32.25283036 30.75699059 0.953621442 -0.06851142 0.972773348 1 0.890928715 0.835391675 55506 macroH2A.2 histone "GO:0000122,GO:0000781,GO:0000785,GO:0000786,GO:0000976,GO:0000977,GO:0001740,GO:0003677,GO:0005515,GO:0005654,GO:0006334,GO:0006342,GO:0007420,GO:0007549,GO:0031490,GO:0045618,GO:0045814,GO:0046982,GO:0070062,GO:0071169,GO:1901837" "negative regulation of transcription by RNA polymerase II|chromosome, telomeric region|chromatin|nucleosome|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|Barr body|DNA binding|protein binding|nucleoplasm|nucleosome assembly|chromatin silencing|brain development|dosage compensation|chromatin DNA binding|positive regulation of keratinocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|extracellular exosome|establishment of protein localization to chromatin|negative regulation of transcription of nucleolar large rRNA by RNA polymerase I" "hsa04217,hsa05034,hsa05322" Necroptosis|Alcoholism|Systemic lupus erythematosus MAD1L1 692.2116556 648.1778489 736.2454623 1.13586952 0.183797119 0.475899092 1 10.31059925 11.51551941 8379 mitotic arrest deficient 1 like 1 "GO:0000776,GO:0000777,GO:0005515,GO:0005635,GO:0005813,GO:0005819,GO:0005829,GO:0007094,GO:0042130,GO:0042802,GO:0043515,GO:0044615,GO:0048538,GO:0051301,GO:0051315,GO:0072686,GO:0090235,GO:0097431" kinetochore|condensed chromosome kinetochore|protein binding|nuclear envelope|centrosome|spindle|cytosol|mitotic spindle assembly checkpoint|negative regulation of T cell proliferation|identical protein binding|kinetochore binding|nuclear pore nuclear basket|thymus development|cell division|attachment of mitotic spindle microtubules to kinetochore|mitotic spindle|regulation of metaphase plate congression|mitotic spindle pole "hsa04110,hsa04114,hsa04914,hsa05166,hsa05203" Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection|Viral carcinogenesis MAD2L1 2113.183431 1983.02886 2243.338001 1.131268458 0.177941332 0.452255453 1 20.24691135 22.52141318 4085 mitotic arrest deficient 2 like 1 "GO:0000132,GO:0000776,GO:0000777,GO:0000922,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0007094,GO:0008022,GO:0031145,GO:0042177,GO:0042802,GO:0042803,GO:0043066,GO:0044615,GO:0045930,GO:0048471,GO:0051301,GO:0051660,GO:0072686,GO:0090267,GO:1901990,GO:1904667" establishment of mitotic spindle orientation|kinetochore|condensed chromosome kinetochore|spindle pole|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|mitotic spindle assembly checkpoint|protein C-terminus binding|anaphase-promoting complex-dependent catabolic process|negative regulation of protein catabolic process|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|nuclear pore nuclear basket|negative regulation of mitotic cell cycle|perinuclear region of cytoplasm|cell division|establishment of centrosome localization|mitotic spindle|positive regulation of mitotic cell cycle spindle assembly checkpoint|regulation of mitotic cell cycle phase transition|negative regulation of ubiquitin protein ligase activity "hsa04110,hsa04114,hsa04914,hsa05166" Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection MAD2L1BP 309.282169 322.5283036 296.0360344 0.917860638 -0.123652974 0.698849195 1 10.61859518 9.583297895 9587 MAD2L1 binding protein "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005819,GO:0007093,GO:0007096,GO:0031965,GO:1902426" protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|spindle|mitotic cell cycle checkpoint|regulation of exit from mitosis|nuclear membrane|deactivation of mitotic spindle assembly checkpoint MAD2L2 1249.818047 1105.959957 1393.676136 1.260150629 0.333596193 0.167000456 1 49.18587521 60.94443327 10459 mitotic arrest deficient 2 like 2 "GO:0000122,GO:0001102,GO:0001558,GO:0005515,GO:0005634,GO:0005654,GO:0005680,GO:0005694,GO:0005730,GO:0005819,GO:0005829,GO:0006302,GO:0007015,GO:0007094,GO:0008432,GO:0010719,GO:0010944,GO:0016035,GO:0033138,GO:0035861,GO:0042177,GO:0042276,GO:0042772,GO:0043433,GO:0045830,GO:0045893,GO:0051301,GO:0090090,GO:1904667,GO:2000042,GO:2000048,GO:2000678,GO:2001034" "negative regulation of transcription by RNA polymerase II|RNA polymerase II activating transcription factor binding|regulation of cell growth|protein binding|nucleus|nucleoplasm|anaphase-promoting complex|chromosome|nucleolus|spindle|cytosol|double-strand break repair|actin filament organization|mitotic spindle assembly checkpoint|JUN kinase binding|negative regulation of epithelial to mesenchymal transition|negative regulation of transcription by competitive promoter binding|zeta DNA polymerase complex|positive regulation of peptidyl-serine phosphorylation|site of double-strand break|negative regulation of protein catabolic process|error-prone translesion synthesis|DNA damage response, signal transduction resulting in transcription|negative regulation of DNA-binding transcription factor activity|positive regulation of isotype switching|positive regulation of transcription, DNA-templated|cell division|negative regulation of canonical Wnt signaling pathway|negative regulation of ubiquitin protein ligase activity|negative regulation of double-strand break repair via homologous recombination|negative regulation of cell-cell adhesion mediated by cadherin|negative regulation of transcription regulatory region DNA binding|positive regulation of double-strand break repair via nonhomologous end joining" "hsa04110,hsa04114,hsa04914,hsa05100" Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Bacterial invasion of epithelial cells MADD 1544.141933 1578.30786 1509.976007 0.956705625 -0.063853015 0.790954283 1 12.61893478 11.87058717 8567 MAP kinase activating death domain "GO:0000187,GO:0005085,GO:0005123,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007166,GO:0010803,GO:0016021,GO:0030295,GO:0032483,GO:0042981,GO:0045202,GO:0051726,GO:0097194,GO:1902041,GO:2001236" activation of MAPK activity|guanyl-nucleotide exchange factor activity|death receptor binding|protein binding|cytoplasm|cytosol|plasma membrane|cell surface receptor signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway|integral component of membrane|protein kinase activator activity|regulation of Rab protein signal transduction|regulation of apoptotic process|synapse|regulation of cell cycle|execution phase of apoptosis|regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of extrinsic apoptotic signaling pathway MAEA 2119.996425 1871.704575 2368.288276 1.26531094 0.33949196 0.15118028 1 35.38414209 44.02274428 10296 "macrophage erythroblast attacher, E3 ubiquitin ligase" "GO:0000151,GO:0003779,GO:0004842,GO:0005634,GO:0005654,GO:0005737,GO:0005819,GO:0005826,GO:0005856,GO:0005887,GO:0007049,GO:0007155,GO:0007346,GO:0016363,GO:0016567,GO:0033033,GO:0034657,GO:0043161,GO:0043249,GO:0045721,GO:0046872,GO:0051301" ubiquitin ligase complex|actin binding|ubiquitin-protein transferase activity|nucleus|nucleoplasm|cytoplasm|spindle|actomyosin contractile ring|cytoskeleton|integral component of plasma membrane|cell cycle|cell adhesion|regulation of mitotic cell cycle|nuclear matrix|protein ubiquitination|negative regulation of myeloid cell apoptotic process|GID complex|proteasome-mediated ubiquitin-dependent protein catabolic process|erythrocyte maturation|negative regulation of gluconeogenesis|metal ion binding|cell division MAF 2.923096831 1.040413883 4.80577978 4.619103859 2.207612985 0.416510993 1 0.001713681 0.007783212 4094 MAF bZIP transcription factor "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0006366,GO:0032330,GO:0045944,GO:0048468,GO:0048839,GO:0070306,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|regulation of chondrocyte differentiation|positive regulation of transcription by RNA polymerase II|cell development|inner ear development|lens fiber cell differentiation|sequence-specific double-stranded DNA binding" "hsa04658,hsa05202,hsa05321" Th1 and Th2 cell differentiation|Transcriptional misregulation in cancer|Inflammatory bowel disease TF_bZIP MAF1 2662.338178 2345.092891 2979.583464 1.270560955 0.34546559 0.144126803 1 72.97568369 91.16850981 84232 "MAF1 homolog, negative regulator of RNA polymerase III" "GO:0000994,GO:0001002,GO:0001003,GO:0001006,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0016479,GO:0016480,GO:0043231" RNA polymerase III core binding|RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 3 promoter sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|negative regulation of transcription by RNA polymerase I|negative regulation of transcription by RNA polymerase III|intracellular membrane-bounded organelle MAFA 3.923881751 2.080827765 5.766935736 2.771462315 1.470647391 0.503574097 1 0.041607326 0.113383527 389692 MAF bZIP transcription factor A "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0005634,GO:0006355,GO:0006357,GO:0007263,GO:0009749,GO:0030073,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|nitric oxide mediated signal transduction|response to glucose|insulin secretion|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" "hsa04930,hsa04950" Type II diabetes mellitus|Maturity onset diabetes of the young MAFF 1876.185489 1766.622773 1985.748205 1.124036345 0.168688685 0.477024112 1 38.59247256 42.65344728 23764 MAF bZIP transcription factor F "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001701,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006357,GO:0007567,GO:0007596,GO:0035914,GO:0043565,GO:0045604,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|in utero embryonic development|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|parturition|blood coagulation|skeletal muscle cell differentiation|sequence-specific DNA binding|regulation of epidermal cell differentiation|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" TF_bZIP MAFG 2711.057764 2690.510301 2731.605227 1.015274027 0.02186917 0.927930552 1 27.74639416 27.69880329 4097 MAF bZIP transcription factor G "GO:0000978,GO:0000981,GO:0001228,GO:0001701,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007596,GO:0030534,GO:0030641,GO:0042127,GO:0045604,GO:0045944,GO:0046982,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|in utero embryonic development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|blood coagulation|adult behavior|regulation of cellular pH|regulation of cell population proliferation|regulation of epidermal cell differentiation|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|sequence-specific double-stranded DNA binding" TF_bZIP MAFK 1058.394526 1089.313335 1027.475717 0.943232479 -0.084314699 0.733136229 1 15.26244437 14.15513512 7975 MAF bZIP transcription factor K "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001221,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007399,GO:0007596,GO:0043565,GO:0071535" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|transcription coregulator binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|nervous system development|blood coagulation|sequence-specific DNA binding|RING-like zinc finger domain binding" TF_bZIP MAGEA1 767.4195939 654.4203322 880.4188557 1.345341537 0.427972471 0.090687477 1 20.41216269 27.00180215 4100 MAGE family member A1 "GO:0000122,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0042826,GO:0045746" negative regulation of transcription by RNA polymerase II|protein binding|nucleus|cytoplasm|plasma membrane|histone deacetylase binding|negative regulation of Notch signaling pathway MAGEA12 567.534368 567.025566 568.04317 1.001794635 0.002586791 0.999896979 1 15.40005716 15.16953306 4111 MAGE family member A12 "GO:0003674,GO:0005515,GO:0005575,GO:0008150" molecular_function|protein binding|cellular_component|biological_process MAGEA2 6.683432311 11.44455271 1.922311912 0.167967413 -2.573746729 0.09106035 1 0.268826912 0.044398567 4101 MAGE family member A2 "GO:0000122,GO:0005515,GO:0005634,GO:0016605,GO:0031625,GO:0033234,GO:0042826,GO:0044257,GO:0051443,GO:0070491,GO:0072331,GO:0090398,GO:1901984" negative regulation of transcription by RNA polymerase II|protein binding|nucleus|PML body|ubiquitin protein ligase binding|negative regulation of protein sumoylation|histone deacetylase binding|cellular protein catabolic process|positive regulation of ubiquitin-protein transferase activity|repressing transcription factor binding|signal transduction by p53 class mediator|cellular senescence|negative regulation of protein acetylation MAGEA2B 7.287927597 2.080827765 12.49502743 6.004835016 2.586124608 0.079871359 1 0.052680244 0.311042714 266740 MAGE family member A2B "GO:0000122,GO:0005515,GO:0005634,GO:0016605,GO:0031625,GO:0033234,GO:0042826,GO:0044257,GO:0051443,GO:0070491,GO:0072331,GO:0090398,GO:1901984" negative regulation of transcription by RNA polymerase II|protein binding|nucleus|PML body|ubiquitin protein ligase binding|negative regulation of protein sumoylation|histone deacetylase binding|cellular protein catabolic process|positive regulation of ubiquitin-protein transferase activity|repressing transcription factor binding|signal transduction by p53 class mediator|cellular senescence|negative regulation of protein acetylation MAGEA3 1413.727893 1422.245778 1405.210008 0.988021923 -0.017385042 0.945260981 1 29.48820636 28.64745967 4102 MAGE family member A3 "GO:0005515,GO:0005783,GO:0010955,GO:0043154,GO:0089720,GO:1902236" protein binding|endoplasmic reticulum|negative regulation of protein processing|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|caspase binding|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway MAGEA6 524.4710484 496.277422 552.6646747 1.113620427 0.15525758 0.569361741 1 15.16919467 16.61004817 4105 MAGE family member A6 "GO:0003674,GO:0005515,GO:0005575,GO:0008150" molecular_function|protein binding|cellular_component|biological_process MAGEB2 1993.218188 1836.330503 2150.105874 1.170870859 0.227581963 0.336419784 1 59.25125992 68.21466734 4113 MAGE family member B2 GO:0005515 protein binding MAGEC3 7.525701377 8.323311061 6.728091692 0.808343175 -0.306960188 0.918003413 1 0.112256713 0.089223504 139081 MAGE family member C3 MAGED1 6474.735514 6091.623283 6857.847746 1.125783297 0.170929149 0.482309744 1 84.77150943 93.83738482 9500 MAGE family member D1 "GO:0000785,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0006355,GO:0032922,GO:0032991,GO:0042802,GO:0042981,GO:0050680" "chromatin|protein binding|nucleus|cytoplasm|plasma membrane|regulation of transcription, DNA-templated|circadian regulation of gene expression|protein-containing complex|identical protein binding|regulation of apoptotic process|negative regulation of epithelial cell proliferation" hsa04722 Neurotrophin signaling pathway MAGED2 3449.226882 3283.546214 3614.90755 1.100915692 0.138703991 0.559260845 1 76.79089681 83.12563578 10916 MAGE family member D2 "GO:0002576,GO:0005515,GO:0005576,GO:0005654,GO:0005730,GO:0005829,GO:0007565,GO:0016020,GO:0031093,GO:0070294" platelet degranulation|protein binding|extracellular region|nucleoplasm|nucleolus|cytosol|female pregnancy|membrane|platelet alpha granule lumen|renal sodium ion absorption MAGEE1 472.4453238 404.7210003 540.1696473 1.334671655 0.416484865 0.132794923 1 5.945283772 7.802220222 57692 MAGE family member E1 "GO:0005515,GO:0005634,GO:0005886,GO:0008150,GO:0030425,GO:0045211,GO:0048471" protein binding|nucleus|plasma membrane|biological_process|dendrite|postsynaptic membrane|perinuclear region of cytoplasm MAGEF1 978.1643846 825.0482089 1131.28056 1.37116904 0.455406439 0.064554933 1 25.88554176 34.89951856 64110 MAGE family member F1 "GO:0005515,GO:0016567,GO:0097428,GO:2000042,GO:2000060" protein binding|protein ubiquitination|protein maturation by iron-sulfur cluster transfer|negative regulation of double-strand break repair via homologous recombination|positive regulation of ubiquitin-dependent protein catabolic process MAGEH1 165.5408926 144.6175297 186.4642555 1.289361365 0.36665666 0.35134337 1 5.359702614 6.794954054 28986 MAGE family member H1 "GO:0005515,GO:0005737,GO:0006915" protein binding|cytoplasm|apoptotic process MAGI1 206.117034 225.7698125 186.4642555 0.825904284 -0.2759535 0.446622794 1 1.210095405 0.982698989 9223 "membrane associated guanylate kinase, WW and PDZ domain containing 1" "GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005737,GO:0005886,GO:0005911,GO:0005912,GO:0005923,GO:0007155,GO:0007165,GO:0007166,GO:0008022,GO:0022409,GO:0030054,GO:0042995,GO:0051393,GO:0060090,GO:0065003,GO:0071944" protein binding|ATP binding|nucleoplasm|nucleolus|cytoplasm|plasma membrane|cell-cell junction|adherens junction|bicellular tight junction|cell adhesion|signal transduction|cell surface receptor signaling pathway|protein C-terminus binding|positive regulation of cell-cell adhesion|cell junction|cell projection|alpha-actinin binding|molecular adaptor activity|protein-containing complex assembly|cell periphery "hsa04015,hsa04151,hsa04530,hsa05165" Rap1 signaling pathway|PI3K-Akt signaling pathway|Tight junction|Human papillomavirus infection MAGI2 91.55703605 82.19269673 100.9213754 1.227863051 0.29614966 0.550271021 1 0.128027353 0.154569526 9863 "membrane associated guanylate kinase, WW and PDZ domain containing 2" "GO:0002092,GO:0003402,GO:0005515,GO:0005634,GO:0005737,GO:0005770,GO:0005886,GO:0005911,GO:0005923,GO:0007165,GO:0007399,GO:0008285,GO:0010976,GO:0014069,GO:0019902,GO:0030159,GO:0030336,GO:0030425,GO:0031697,GO:0032516,GO:0032926,GO:0032991,GO:0036057,GO:0038180,GO:0043113,GO:0045202,GO:0046332,GO:0048471,GO:0051898,GO:0060395,GO:0070699,GO:0071850,GO:0072015,GO:1990090" positive regulation of receptor internalization|planar cell polarity pathway involved in axis elongation|protein binding|nucleus|cytoplasm|late endosome|plasma membrane|cell-cell junction|bicellular tight junction|signal transduction|nervous system development|negative regulation of cell population proliferation|positive regulation of neuron projection development|postsynaptic density|phosphatase binding|signaling receptor complex adaptor activity|negative regulation of cell migration|dendrite|beta-1 adrenergic receptor binding|positive regulation of phosphoprotein phosphatase activity|negative regulation of activin receptor signaling pathway|protein-containing complex|slit diaphragm|nerve growth factor signaling pathway|receptor clustering|synapse|SMAD binding|perinuclear region of cytoplasm|negative regulation of protein kinase B signaling|SMAD protein signal transduction|type II activin receptor binding|mitotic cell cycle arrest|glomerular visceral epithelial cell development|cellular response to nerve growth factor stimulus "hsa04015,hsa04151" Rap1 signaling pathway|PI3K-Akt signaling pathway MAGI3 557.6353449 584.712602 530.5580877 0.90738268 -0.140216973 0.602856552 1 4.296439063 3.833278032 260425 "membrane associated guanylate kinase, WW and PDZ domain containing 3" "GO:0004385,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005886,GO:0005911,GO:0005923,GO:0006915,GO:0007165,GO:0016020,GO:0016032,GO:0030054,GO:0035556,GO:0046037,GO:0046328,GO:0046710,GO:0060090" guanylate kinase activity|protein binding|ATP binding|nucleus|cytoplasm|plasma membrane|cell-cell junction|bicellular tight junction|apoptotic process|signal transduction|membrane|viral process|cell junction|intracellular signal transduction|GMP metabolic process|regulation of JNK cascade|GDP metabolic process|molecular adaptor activity hsa04015 Rap1 signaling pathway MAGIX 11.00863411 11.44455271 10.57271552 0.923820772 -0.11431511 1 1 0.21735756 0.197439322 79917 "MAGI family member, X-linked" MAGOH 673.0382263 624.2483296 721.828123 1.156315666 0.209535297 0.417869313 1 50.78503968 57.74087811 4116 "mago homolog, exon junction complex subunit" "GO:0000184,GO:0000381,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006405,GO:0006406,GO:0006417,GO:0008380,GO:0016607,GO:0031124,GO:0035145,GO:0071013" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|RNA export from nucleus|mRNA export from nucleus|regulation of translation|RNA splicing|nuclear speck|mRNA 3'-end processing|exon-exon junction complex|catalytic step 2 spliceosome" "hsa03013,hsa03015,hsa03040" RNA transport|mRNA surveillance pathway|Spliceosome MAGOHB 456.1748696 431.7717613 480.577978 1.113037074 0.154501649 0.584484345 1 7.816440074 8.554405082 55110 "mago homolog B, exon junction complex subunit" "GO:0000184,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006405,GO:0006406,GO:0008380,GO:0031124,GO:0035145,GO:0043025,GO:0071005,GO:0071006,GO:0071013" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|RNA export from nucleus|mRNA export from nucleus|RNA splicing|mRNA 3'-end processing|exon-exon junction complex|neuronal cell body|U2-type precatalytic spliceosome|U2-type catalytic step 1 spliceosome|catalytic step 2 spliceosome" "hsa03013,hsa03015,hsa03040" RNA transport|mRNA surveillance pathway|Spliceosome MAGT1 3555.774956 3532.205132 3579.34478 1.013345671 0.019126389 0.937028607 1 40.63533002 40.48858381 84061 magnesium transporter 1 "GO:0005783,GO:0005886,GO:0005887,GO:0006487,GO:0008250,GO:0015095,GO:0015693,GO:0016020,GO:0018279,GO:0035577,GO:0043312,GO:0050890,GO:0055085,GO:1903830" endoplasmic reticulum|plasma membrane|integral component of plasma membrane|protein N-linked glycosylation|oligosaccharyltransferase complex|magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|protein N-linked glycosylation via asparagine|azurophil granule membrane|neutrophil degranulation|cognition|transmembrane transport|magnesium ion transmembrane transport MAIP1 282.9497598 274.669265 291.2302547 1.060294295 0.084464754 0.80251021 1 9.746405488 10.16113167 79568 matrix AAA peptidase interacting protein 1 "GO:0005515,GO:0005743,GO:0005759,GO:0006851,GO:0007007,GO:0032979,GO:0036444,GO:0043022,GO:0051204,GO:0051560" protein binding|mitochondrial inner membrane|mitochondrial matrix|mitochondrial calcium ion transmembrane transport|inner mitochondrial membrane organization|protein insertion into mitochondrial inner membrane from matrix|calcium import into the mitochondrion|ribosome binding|protein insertion into mitochondrial membrane|mitochondrial calcium ion homeostasis MAK 6.083967443 8.323311061 3.844623824 0.461910386 -1.11431511 0.492415049 1 0.062873293 0.028555851 4117 male germ cell associated kinase "GO:0000165,GO:0001750,GO:0001917,GO:0003713,GO:0004672,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005929,GO:0005930,GO:0006468,GO:0007275,GO:0007283,GO:0010468,GO:0030154,GO:0030496,GO:0031514,GO:0032391,GO:0035556,GO:0042073,GO:0045494,GO:0045893,GO:0046777,GO:0046872,GO:0060271,GO:0072686,GO:0106310,GO:0106311,GO:1902856" "MAPK cascade|photoreceptor outer segment|photoreceptor inner segment|transcription coactivator activity|protein kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|cytoplasm|centrosome|cilium|axoneme|protein phosphorylation|multicellular organism development|spermatogenesis|regulation of gene expression|cell differentiation|midbody|motile cilium|photoreceptor connecting cilium|intracellular signal transduction|intraciliary transport|photoreceptor cell maintenance|positive regulation of transcription, DNA-templated|protein autophosphorylation|metal ion binding|cilium assembly|mitotic spindle|protein serine kinase activity|protein threonine kinase activity|negative regulation of non-motile cilium assembly" MAK16 380.8480444 422.4080364 339.2880525 0.803223479 -0.316126654 0.281655268 1 6.330564602 4.999769908 84549 MAK16 homolog "GO:0000460,GO:0000470,GO:0003723,GO:0005515,GO:0005730,GO:0030687,GO:0043231" "maturation of 5.8S rRNA|maturation of LSU-rRNA|RNA binding|protein binding|nucleolus|preribosome, large subunit precursor|intracellular membrane-bounded organelle" MAL2 6.123596406 9.363724944 2.883467868 0.307940257 -1.699277611 0.271781165 1 0.176831136 0.053542221 114569 "mal, T cell differentiation protein 2" "GO:0005515,GO:0012505,GO:0016021,GO:0016324,GO:0019911,GO:0042552,GO:0045056,GO:0045121,GO:0048471,GO:0070062" protein binding|endomembrane system|integral component of membrane|apical plasma membrane|structural constituent of myelin sheath|myelination|transcytosis|membrane raft|perinuclear region of cytoplasm|extracellular exosome MALL 157.0144063 135.2538047 178.7750078 1.321774335 0.402475888 0.315447469 1 2.95829794 3.844770352 7851 "mal, T cell differentiation protein like" "GO:0000139,GO:0005515,GO:0005886,GO:0016021,GO:0019911,GO:0030136,GO:0031410,GO:0042552,GO:0042632,GO:0045121" Golgi membrane|protein binding|plasma membrane|integral component of membrane|structural constituent of myelin sheath|clathrin-coated vesicle|cytoplasmic vesicle|myelination|cholesterol homeostasis|membrane raft MALSU1 500.2244974 440.0950724 560.3539223 1.273256525 0.34852311 0.202538004 1 7.09364698 8.880893472 115416 mitochondrial assembly of ribosomal large subunit 1 "GO:0005515,GO:0005739,GO:0005762,GO:0005829,GO:0017148,GO:0042273,GO:0043023,GO:0070130,GO:0090071" protein binding|mitochondrion|mitochondrial large ribosomal subunit|cytosol|negative regulation of translation|ribosomal large subunit biogenesis|ribosomal large subunit binding|negative regulation of mitochondrial translation|negative regulation of ribosome biogenesis MALT1 1729.45572 1749.976151 1708.93529 0.97654776 -0.034237491 0.887662836 1 9.937541055 9.542092068 10892 MALT1 paracaspase "GO:0001650,GO:0001923,GO:0002020,GO:0002096,GO:0002223,GO:0002726,GO:0004197,GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0006952,GO:0007250,GO:0008233,GO:0009620,GO:0016567,GO:0019209,GO:0031398,GO:0031663,GO:0032449,GO:0032731,GO:0032743,GO:0032991,GO:0038095,GO:0042098,GO:0042113,GO:0042802,GO:0042981,GO:0043066,GO:0043123,GO:0043280,GO:0043621,GO:0045087,GO:0048471,GO:0050852,GO:0050856,GO:0051092,GO:0051168,GO:2000321" fibrillar center|B-1 B cell differentiation|protease binding|polkadots|stimulatory C-type lectin receptor signaling pathway|positive regulation of T cell cytokine production|cysteine-type endopeptidase activity|ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|cytosol|proteolysis|defense response|activation of NF-kappaB-inducing kinase activity|peptidase activity|response to fungus|protein ubiquitination|kinase activator activity|positive regulation of protein ubiquitination|lipopolysaccharide-mediated signaling pathway|CBM complex|positive regulation of interleukin-1 beta production|positive regulation of interleukin-2 production|protein-containing complex|Fc-epsilon receptor signaling pathway|T cell proliferation|B cell activation|identical protein binding|regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein self-association|innate immune response|perinuclear region of cytoplasm|T cell receptor signaling pathway|regulation of T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|nuclear export|positive regulation of T-helper 17 cell differentiation "hsa04064,hsa04625,hsa04660,hsa04662,hsa05131,hsa05152" NF-kappa B signaling pathway|C-type lectin receptor signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Shigellosis|Tuberculosis MAMDC2 757.173971 637.7737101 876.5742319 1.374428293 0.458831641 0.070222758 1 6.607806392 8.929981828 256691 MAM domain containing 2 "GO:0005515,GO:0005576,GO:0005783,GO:0016020" protein binding|extracellular region|endoplasmic reticulum|membrane MAMDC4 25.53982992 27.05076095 24.0288989 0.888289204 -0.170898638 0.873378185 1 0.392189458 0.342548033 158056 MAM domain containing 4 "GO:0015031,GO:0016021" protein transport|integral component of membrane MAML1 976.7805581 1078.909196 874.65192 0.81068168 -0.302792554 0.219082965 1 10.01729312 7.984944824 9794 mastermind like transcriptional coactivator 1 "GO:0002193,GO:0003162,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006367,GO:0006468,GO:0007219,GO:0007221,GO:0010831,GO:0016607,GO:0019901,GO:0042605,GO:0043231,GO:0045445,GO:0045747,GO:0045944,GO:0060928" MAML1-RBP-Jkappa- ICN1 complex|atrioventricular node development|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|protein phosphorylation|Notch signaling pathway|positive regulation of transcription of Notch receptor target|positive regulation of myotube differentiation|nuclear speck|protein kinase binding|peptide antigen binding|intracellular membrane-bounded organelle|myoblast differentiation|positive regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|atrioventricular node cell development "hsa04330,hsa04658,hsa05165" Notch signaling pathway|Th1 and Th2 cell differentiation|Human papillomavirus infection MAML2 756.8557105 831.2906922 682.4207288 0.820917081 -0.284691588 0.261523718 1 4.137317579 3.339560606 84441 mastermind like transcriptional coactivator 2 "GO:0003713,GO:0005634,GO:0005654,GO:0006367,GO:0007219,GO:0007221,GO:0016607,GO:0045747,GO:0045944" transcription coactivator activity|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|Notch signaling pathway|positive regulation of transcription of Notch receptor target|nuclear speck|positive regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II "hsa04330,hsa04658,hsa05165" Notch signaling pathway|Th1 and Th2 cell differentiation|Human papillomavirus infection MAML3 176.7671788 212.2444321 141.2899255 0.66569438 -0.587068107 0.123200827 1 1.655040218 1.083314661 55534 mastermind like transcriptional coactivator 3 "GO:0003713,GO:0005634,GO:0005654,GO:0006367,GO:0007219,GO:0007221,GO:0016607,GO:0045747,GO:0045944" transcription coactivator activity|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|Notch signaling pathway|positive regulation of transcription of Notch receptor target|nuclear speck|positive regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II "hsa04330,hsa04658,hsa05165" Notch signaling pathway|Th1 and Th2 cell differentiation|Human papillomavirus infection other MAMLD1 510.7123101 551.4193578 470.0052625 0.852355391 -0.230473004 0.398420403 1 5.540997488 4.643867762 10046 mastermind like domain containing 1 "GO:0003674,GO:0005654,GO:0005794,GO:0005813,GO:0006357,GO:0008584,GO:0016604" molecular_function|nucleoplasm|Golgi apparatus|centrosome|regulation of transcription by RNA polymerase II|male gonad development|nuclear body MAMSTR 34.75006943 29.13158871 40.36855015 1.385731158 0.470647391 0.510308519 1 0.530795271 0.723231287 284358 MEF2 activating motif and SAP domain containing transcriptional regulator "GO:0001085,GO:0003712,GO:0005634,GO:0006357,GO:0010831,GO:0045944,GO:0051059" RNA polymerase II transcription factor binding|transcription coregulator activity|nucleus|regulation of transcription by RNA polymerase II|positive regulation of myotube differentiation|positive regulation of transcription by RNA polymerase II|NF-kappaB binding MAN1A1 1078.72284 1030.009744 1127.435936 1.094587642 0.130387473 0.595353777 1 10.37360388 11.16481109 4121 mannosidase alpha class 1A member 1 "GO:0000139,GO:0004571,GO:0005509,GO:0005783,GO:0005793,GO:0005794,GO:0005829,GO:0005975,GO:0006486,GO:0006491,GO:0015923,GO:0016020,GO:0016021,GO:0030433,GO:0031410,GO:0045047,GO:0070062,GO:1904381,GO:1904382" "Golgi membrane|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|carbohydrate metabolic process|protein glycosylation|N-glycan processing|mannosidase activity|membrane|integral component of membrane|ubiquitin-dependent ERAD pathway|cytoplasmic vesicle|protein targeting to ER|extracellular exosome|Golgi apparatus mannose trimming|mannose trimming involved in glycoprotein ERAD pathway" "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum MAN1A2 1012.189229 1163.182721 861.1957366 0.740378722 -0.433664661 0.077319735 1 7.079941146 5.154122723 10905 mannosidase alpha class 1A member 2 "GO:0000139,GO:0004571,GO:0005509,GO:0005783,GO:0005794,GO:0005975,GO:0006486,GO:0006491,GO:0007585,GO:0016020,GO:0016021,GO:0048286,GO:0070062,GO:1904381" "Golgi membrane|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum|Golgi apparatus|carbohydrate metabolic process|protein glycosylation|N-glycan processing|respiratory gaseous exchange by respiratory system|membrane|integral component of membrane|lung alveolus development|extracellular exosome|Golgi apparatus mannose trimming" "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum MAN1B1 1408.391845 1446.175297 1370.608393 0.947747065 -0.077426011 0.748610629 1 21.54052962 20.07335679 11253 mannosidase alpha class 1B member 1 "GO:0004571,GO:0005509,GO:0005783,GO:0005789,GO:0005794,GO:0006486,GO:0006491,GO:0009311,GO:0016020,GO:0016021,GO:0030433,GO:0031410,GO:0036508,GO:0036509,GO:0036510,GO:0036511,GO:0036512,GO:0044322,GO:1903561,GO:1904380,GO:1904382" "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein glycosylation|N-glycan processing|oligosaccharide metabolic process|membrane|integral component of membrane|ubiquitin-dependent ERAD pathway|cytoplasmic vesicle|protein alpha-1,2-demannosylation|trimming of terminal mannose on B branch|trimming of terminal mannose on C branch|trimming of first mannose on A branch|trimming of second mannose on A branch|endoplasmic reticulum quality control compartment|extracellular vesicle|endoplasmic reticulum mannose trimming|mannose trimming involved in glycoprotein ERAD pathway" "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum MAN1C1 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.013795025 0.037592625 57134 mannosidase alpha class 1C member 1 "GO:0000139,GO:0004571,GO:0005509,GO:0005515,GO:0005783,GO:0005975,GO:0006487,GO:0006491,GO:0030173,GO:0070062,GO:1904381" "Golgi membrane|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|protein binding|endoplasmic reticulum|carbohydrate metabolic process|protein N-linked glycosylation|N-glycan processing|integral component of Golgi membrane|extracellular exosome|Golgi apparatus mannose trimming" "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum MAN2A1 2109.596088 2040.251624 2178.940552 1.067976384 0.094879746 0.689500162 1 22.03247255 23.136415 4124 mannosidase alpha class 2A member 1 "GO:0000139,GO:0001701,GO:0001889,GO:0004559,GO:0004572,GO:0005797,GO:0005801,GO:0006013,GO:0006486,GO:0006491,GO:0006517,GO:0007005,GO:0007033,GO:0007585,GO:0016020,GO:0016021,GO:0016799,GO:0030246,GO:0042803,GO:0046872,GO:0048286,GO:0050769,GO:0060042,GO:0070062" "Golgi membrane|in utero embryonic development|liver development|alpha-mannosidase activity|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|Golgi medial cisterna|cis-Golgi network|mannose metabolic process|protein glycosylation|N-glycan processing|protein deglycosylation|mitochondrion organization|vacuole organization|respiratory gaseous exchange by respiratory system|membrane|integral component of membrane|hydrolase activity, hydrolyzing N-glycosyl compounds|carbohydrate binding|protein homodimerization activity|metal ion binding|lung alveolus development|positive regulation of neurogenesis|retina morphogenesis in camera-type eye|extracellular exosome" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis MAN2A2 846.2677521 869.7860059 822.7494983 0.945921747 -0.080207256 0.75196088 1 8.074253007 7.509806426 4122 mannosidase alpha class 2A member 2 "GO:0000139,GO:0004559,GO:0004572,GO:0006013,GO:0006486,GO:0006491,GO:0006517,GO:0016021,GO:0016799,GO:0030246,GO:0046872" "Golgi membrane|alpha-mannosidase activity|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|mannose metabolic process|protein glycosylation|N-glycan processing|protein deglycosylation|integral component of membrane|hydrolase activity, hydrolyzing N-glycosyl compounds|carbohydrate binding|metal ion binding" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis MAN2B1 2043.776412 2091.231904 1996.320921 0.954614797 -0.067009395 0.778557089 1 35.02988173 32.88046962 4125 mannosidase alpha class 2B member 1 "GO:0004559,GO:0005576,GO:0005615,GO:0005654,GO:0005764,GO:0005774,GO:0006013,GO:0006464,GO:0006517,GO:0009313,GO:0030246,GO:0035578,GO:0043202,GO:0043231,GO:0043312,GO:0046872,GO:0070062" alpha-mannosidase activity|extracellular region|extracellular space|nucleoplasm|lysosome|vacuolar membrane|mannose metabolic process|cellular protein modification process|protein deglycosylation|oligosaccharide catabolic process|carbohydrate binding|azurophil granule lumen|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|metal ion binding|extracellular exosome "hsa00511,hsa04142" Other glycan degradation|Lysosome MAN2B2 826.2319321 898.9175946 753.5462695 0.838281811 -0.254492768 0.310463323 1 9.475326858 7.810078912 23324 mannosidase alpha class 2B member 2 "GO:0004559,GO:0005515,GO:0005764,GO:0005774,GO:0006013,GO:0009313,GO:0030246,GO:0043202,GO:0046872,GO:0070062" alpha-mannosidase activity|protein binding|lysosome|vacuolar membrane|mannose metabolic process|oligosaccharide catabolic process|carbohydrate binding|lysosomal lumen|metal ion binding|extracellular exosome hsa00511 Other glycan degradation MAN2C1 540.4238564 561.8234966 519.0242162 0.923820772 -0.11431511 0.674927408 1 9.052985334 8.223386798 4123 mannosidase alpha class 2C member 1 "GO:0004559,GO:0005654,GO:0005829,GO:0006013,GO:0009313,GO:0030246,GO:0046872" alpha-mannosidase activity|nucleoplasm|cytosol|mannose metabolic process|oligosaccharide catabolic process|carbohydrate binding|metal ion binding hsa00511 Other glycan degradation MANBA 582.8480823 628.4099851 537.2861794 0.854993065 -0.226015376 0.394146622 1 4.449659803 3.740766319 4126 mannosidase beta "GO:0004567,GO:0005764,GO:0005886,GO:0006464,GO:0006516,GO:0009313,GO:0035577,GO:0043202,GO:0043312" beta-mannosidase activity|lysosome|plasma membrane|cellular protein modification process|glycoprotein catabolic process|oligosaccharide catabolic process|azurophil granule membrane|lysosomal lumen|neutrophil degranulation "hsa00511,hsa04142" Other glycan degradation|Lysosome MANBAL 1435.33881 1459.700677 1410.976943 0.966620736 -0.048978151 0.840359689 1 16.29057765 15.48330862 63905 mannosidase beta like "GO:0005515,GO:0016021" protein binding|integral component of membrane MANEA 354.124376 351.6598923 356.5888597 1.014016291 0.02008083 0.956878873 1 3.67053435 3.659699305 79694 mannosidase endo-alpha "GO:0000139,GO:0004559,GO:0004569,GO:0005794,GO:0016021" "Golgi membrane|alpha-mannosidase activity|glycoprotein endo-alpha-1,2-mannosidase activity|Golgi apparatus|integral component of membrane" MANEAL 341.5796588 375.5894116 307.5699059 0.818899299 -0.288242042 0.342198853 1 6.864560478 5.527317519 149175 mannosidase endo-alpha like "GO:0000139,GO:0004559,GO:0005794,GO:0016021" Golgi membrane|alpha-mannosidase activity|Golgi apparatus|integral component of membrane MANF 3013.808027 2526.124907 3501.491148 1.386111644 0.471043464 0.046858626 1 148.3109389 202.1354914 7873 mesencephalic astrocyte derived neurotrophic factor "GO:0002576,GO:0003723,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005783,GO:0005788,GO:0005829,GO:0006986,GO:0007165,GO:0008083,GO:0031175,GO:0033018,GO:0048471,GO:0071542,GO:0120146,GO:1905897" platelet degranulation|RNA binding|protein binding|extracellular region|extracellular space|nucleus|endoplasmic reticulum|endoplasmic reticulum lumen|cytosol|response to unfolded protein|signal transduction|growth factor activity|neuron projection development|sarcoplasmic reticulum lumen|perinuclear region of cytoplasm|dopaminergic neuron differentiation|sulfatide binding|regulation of response to endoplasmic reticulum stress MANSC1 249.1954449 259.0630568 239.327833 0.923820772 -0.11431511 0.742430533 1 2.499226175 2.270201793 54682 MANSC domain containing 1 "GO:0005515,GO:0016021" protein binding|integral component of membrane MAOA 188.4054603 151.9004269 224.9104937 1.480644251 0.566225051 0.128139838 1 1.520376332 2.213466754 4128 monoamine oxidase A "GO:0005515,GO:0005739,GO:0005741,GO:0005829,GO:0006576,GO:0008131,GO:0009967,GO:0016021,GO:0019221,GO:0042133,GO:0042135,GO:0042420,GO:0055114" protein binding|mitochondrion|mitochondrial outer membrane|cytosol|cellular biogenic amine metabolic process|primary amine oxidase activity|positive regulation of signal transduction|integral component of membrane|cytokine-mediated signaling pathway|neurotransmitter metabolic process|neurotransmitter catabolic process|dopamine catabolic process|oxidation-reduction process "hsa00260,hsa00330,hsa00340,hsa00350,hsa00360,hsa00380,hsa00982,hsa04726,hsa04728,hsa05012,hsa05030,hsa05031,hsa05034" "Glycine, serine and threonine metabolism|Arginine and proline metabolism|Histidine metabolism|Tyrosine metabolism|Phenylalanine metabolism|Tryptophan metabolism|Drug metabolism - cytochrome P450|Serotonergic synapse|Dopaminergic synapse|Parkinson disease|Cocaine addiction|Amphetamine addiction|Alcoholism" MAP1A 78.4971423 92.59683556 64.39744905 0.695460581 -0.52395935 0.306860366 1 0.481367906 0.329170441 4130 microtubule associated protein 1A "GO:0000226,GO:0003779,GO:0005198,GO:0005515,GO:0005737,GO:0005829,GO:0005874,GO:0005875,GO:0007409,GO:0007613,GO:0008017,GO:0008093,GO:0008306,GO:0015631,GO:0016358,GO:0030424,GO:0030425,GO:0031114,GO:0032435,GO:0043005,GO:0043025,GO:0043194,GO:0043198,GO:0044307,GO:0045202,GO:0048156,GO:0048167,GO:0050882,GO:0070050,GO:0099641,GO:0099642,GO:0150001,GO:1901588,GO:1902817,GO:1903829,GO:1904115,GO:1990535,GO:2000010" microtubule cytoskeleton organization|actin binding|structural molecule activity|protein binding|cytoplasm|cytosol|microtubule|microtubule associated complex|axonogenesis|memory|microtubule binding|cytoskeletal anchor activity|associative learning|tubulin binding|dendrite development|axon|dendrite|regulation of microtubule depolymerization|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|neuron projection|neuronal cell body|axon initial segment|dendritic shaft|dendritic branch|synapse|tau protein binding|regulation of synaptic plasticity|voluntary musculoskeletal movement|neuron cellular homeostasis|anterograde axonal protein transport|retrograde axonal protein transport|primary dendrite|dendritic microtubule|negative regulation of protein localization to microtubule|positive regulation of cellular protein localization|axon cytoplasm|neuron projection maintenance|positive regulation of protein localization to cell surface MAP1B 10144.4245 10078.48928 10210.35972 1.013084346 0.018754293 0.940985743 1 45.15745525 44.98277498 4131 microtubule associated protein 1B "GO:0000226,GO:0001578,GO:0001750,GO:0001764,GO:0003779,GO:0005198,GO:0005515,GO:0005543,GO:0005829,GO:0005874,GO:0005875,GO:0005886,GO:0007026,GO:0007409,GO:0007416,GO:0008017,GO:0009612,GO:0009743,GO:0009987,GO:0010035,GO:0014012,GO:0014069,GO:0016358,GO:0017085,GO:0021700,GO:0030424,GO:0030425,GO:0030426,GO:0031114,GO:0031116,GO:0032355,GO:0032387,GO:0033189,GO:0036477,GO:0042493,GO:0043025,GO:0043196,GO:0043197,GO:0043204,GO:0044877,GO:0045202,GO:0045666,GO:0045773,GO:0047497,GO:0048471,GO:0048675,GO:0051915,GO:0061162,GO:0071363,GO:0071375,GO:0097440,GO:0097441,GO:0097457" microtubule cytoskeleton organization|microtubule bundle formation|photoreceptor outer segment|neuron migration|actin binding|structural molecule activity|protein binding|phospholipid binding|cytosol|microtubule|microtubule associated complex|plasma membrane|negative regulation of microtubule depolymerization|axonogenesis|synapse assembly|microtubule binding|response to mechanical stimulus|response to carbohydrate|cellular process|response to inorganic substance|peripheral nervous system axon regeneration|postsynaptic density|dendrite development|response to insecticide|developmental maturation|axon|dendrite|growth cone|regulation of microtubule depolymerization|positive regulation of microtubule polymerization|response to estradiol|negative regulation of intracellular transport|response to vitamin A|somatodendritic compartment|response to drug|neuronal cell body|varicosity|dendritic spine|perikaryon|protein-containing complex binding|synapse|positive regulation of neuron differentiation|positive regulation of axon extension|mitochondrion transport along microtubule|perinuclear region of cytoplasm|axon extension|induction of synaptic plasticity by chemical substance|establishment of monopolar cell polarity|cellular response to growth factor stimulus|cellular response to peptide hormone stimulus|apical dendrite|basal dendrite|hippocampal mossy fiber MAP1LC3B 3577.426731 3368.860152 3785.993311 1.123820266 0.168411321 0.478458136 1 83.74004407 92.53397593 81631 microtubule associated protein 1 light chain 3 beta "GO:0000045,GO:0000421,GO:0000422,GO:0000423,GO:0005515,GO:0005739,GO:0005776,GO:0005829,GO:0005874,GO:0005930,GO:0006914,GO:0006995,GO:0008017,GO:0009267,GO:0012505,GO:0016236,GO:0031090,GO:0031410,GO:0031625,GO:0043231,GO:0097352" autophagosome assembly|autophagosome membrane|autophagy of mitochondrion|mitophagy|protein binding|mitochondrion|autophagosome|cytosol|microtubule|axoneme|autophagy|cellular response to nitrogen starvation|microtubule binding|cellular response to starvation|endomembrane system|macroautophagy|organelle membrane|cytoplasmic vesicle|ubiquitin protein ligase binding|intracellular membrane-bounded organelle|autophagosome maturation hsa04216 Ferroptosis MAP1LC3B2 99.52368645 89.47559391 109.571779 1.224599628 0.29231015 0.542855393 1 5.837589239 7.029085635 643246 microtubule associated protein 1 light chain 3 beta 2 "GO:0000045,GO:0000421,GO:0000422,GO:0005776,GO:0005829,GO:0005874,GO:0006995,GO:0008017,GO:0012505,GO:0016236,GO:0031410,GO:0031625,GO:0043231,GO:0097352" autophagosome assembly|autophagosome membrane|autophagy of mitochondrion|autophagosome|cytosol|microtubule|cellular response to nitrogen starvation|microtubule binding|endomembrane system|macroautophagy|cytoplasmic vesicle|ubiquitin protein ligase binding|intracellular membrane-bounded organelle|autophagosome maturation hsa04216 Ferroptosis MAP1S 649.6087922 627.3695712 671.8480132 1.070896716 0.098819344 0.707352562 1 8.815576872 9.282597125 55201 microtubule associated protein 1S "GO:0000226,GO:0001578,GO:0003677,GO:0003779,GO:0004536,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005819,GO:0005829,GO:0005874,GO:0005875,GO:0006259,GO:0006914,GO:0006915,GO:0007399,GO:0007409,GO:0007420,GO:0008017,GO:0010848,GO:0015631,GO:0016358,GO:0030054,GO:0030425,GO:0031114,GO:0042995,GO:0043025,GO:0045202,GO:0047497,GO:0048471,GO:0048487,GO:0048812,GO:0051015" microtubule cytoskeleton organization|microtubule bundle formation|DNA binding|actin binding|deoxyribonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|spindle|cytosol|microtubule|microtubule associated complex|DNA metabolic process|autophagy|apoptotic process|nervous system development|axonogenesis|brain development|microtubule binding|regulation of chromatin disassembly|tubulin binding|dendrite development|cell junction|dendrite|regulation of microtubule depolymerization|cell projection|neuronal cell body|synapse|mitochondrion transport along microtubule|perinuclear region of cytoplasm|beta-tubulin binding|neuron projection morphogenesis|actin filament binding MAP2 531.8627716 538.9343912 524.791152 0.97375703 -0.038366257 0.893798639 1 2.506486966 2.399867338 4133 microtubule associated protein 2 "GO:0000226,GO:0001578,GO:0002162,GO:0005198,GO:0005515,GO:0005516,GO:0005737,GO:0005829,GO:0005874,GO:0005875,GO:0008017,GO:0016358,GO:0021954,GO:0030425,GO:0030517,GO:0031113,GO:0031115,GO:0031175,GO:0032839,GO:0043005,GO:0043025,GO:0043194,GO:0043198,GO:0043203,GO:0044294,GO:0044304,GO:0044307,GO:0048156,GO:0048813,GO:0097441,GO:0150001,GO:0150002,GO:0150014,GO:1901953,GO:1902513,GO:1902737,GO:1903744,GO:1903827,GO:1904527,GO:1990635,GO:1990769,GO:2000575" microtubule cytoskeleton organization|microtubule bundle formation|dystroglycan binding|structural molecule activity|protein binding|calmodulin binding|cytoplasm|cytosol|microtubule|microtubule associated complex|microtubule binding|dendrite development|central nervous system neuron development|dendrite|negative regulation of axon extension|regulation of microtubule polymerization|negative regulation of microtubule polymerization|neuron projection development|dendrite cytoplasm|neuron projection|neuronal cell body|axon initial segment|dendritic shaft|axon hillock|dendritic growth cone|main axon|dendritic branch|tau protein binding|dendrite morphogenesis|basal dendrite|primary dendrite|distal dendrite|apical distal dendrite|positive regulation of anterograde dense core granule transport|regulation of organelle transport along microtubule|dendritic filopodium|positive regulation of anterograde synaptic vesicle transport|regulation of cellular protein localization|negative regulation of microtubule binding|proximal dendrite|proximal neuron projection|negative regulation of microtubule motor activity MAP2K1 1379.439508 1241.213762 1517.665255 1.222726738 0.290102018 0.226375491 1 17.13432417 20.60001644 5604 mitogen-activated protein kinase kinase 1 "GO:0000165,GO:0000187,GO:0004672,GO:0004674,GO:0004708,GO:0004712,GO:0004713,GO:0005078,GO:0005515,GO:0005524,GO:0005634,GO:0005739,GO:0005769,GO:0005770,GO:0005783,GO:0005794,GO:0005815,GO:0005829,GO:0005886,GO:0005925,GO:0006468,GO:0006935,GO:0007050,GO:0007165,GO:0007507,GO:0008022,GO:0008285,GO:0010628,GO:0010629,GO:0018107,GO:0018108,GO:0021697,GO:0030182,GO:0030216,GO:0030878,GO:0032872,GO:0043539,GO:0045893,GO:0047485,GO:0048538,GO:0048679,GO:0048870,GO:0050772,GO:0060020,GO:0060324,GO:0060440,GO:0060502,GO:0060674,GO:0060711,GO:0070371,GO:0070374,GO:0071902,GO:0090170,GO:0090398,GO:0097110,GO:1903800,GO:2000641" "MAPK cascade|activation of MAPK activity|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|MAP-kinase scaffold activity|protein binding|ATP binding|nucleus|mitochondrion|early endosome|late endosome|endoplasmic reticulum|Golgi apparatus|microtubule organizing center|cytosol|plasma membrane|focal adhesion|protein phosphorylation|chemotaxis|cell cycle arrest|signal transduction|heart development|protein C-terminus binding|negative regulation of cell population proliferation|positive regulation of gene expression|negative regulation of gene expression|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|cerebellar cortex formation|neuron differentiation|keratinocyte differentiation|thyroid gland development|regulation of stress-activated MAPK cascade|protein serine/threonine kinase activator activity|positive regulation of transcription, DNA-templated|protein N-terminus binding|thymus development|regulation of axon regeneration|cell motility|positive regulation of axonogenesis|Bergmann glial cell differentiation|face development|trachea formation|epithelial cell proliferation involved in lung morphogenesis|placenta blood vessel development|labyrinthine layer development|ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein serine/threonine kinase activity|regulation of Golgi inheritance|cellular senescence|scaffold protein binding|positive regulation of production of miRNAs involved in gene silencing by miRNA|regulation of early endosome to late endosome transport" "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04066,hsa04068,hsa04071,hsa04072,hsa04114,hsa04140,hsa04150,hsa04151,hsa04210,hsa04218,hsa04270,hsa04370,hsa04371,hsa04380,hsa04510,hsa04540,hsa04550,hsa04620,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04720,hsa04722,hsa04725,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04914,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04928,hsa04929,hsa04934,hsa04935,hsa05010,hsa05022,hsa05034,hsa05132,hsa05135,hsa05160,hsa05161,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05170,hsa05200,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Cellular senescence|Vascular smooth muscle contraction|VEGF signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Focal adhesion|Gap junction|Signaling pathways regulating pluripotency of stem cells|Toll-like receptor signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Cushing syndrome|Growth hormone synthesis, secretion and action|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|Salmonella infection|Yersinia infection|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" MAP2K2 2422.708404 2299.314681 2546.102127 1.107330871 0.147086364 0.534365083 1 46.01057313 50.0963667 5605 mitogen-activated protein kinase kinase 2 "GO:0000165,GO:0000187,GO:0004674,GO:0004708,GO:0004712,GO:0004713,GO:0005078,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005739,GO:0005769,GO:0005770,GO:0005778,GO:0005783,GO:0005794,GO:0005829,GO:0005874,GO:0005911,GO:0005925,GO:0009898,GO:0010629,GO:0018108,GO:0030165,GO:0032872,GO:0036289,GO:0043539,GO:0045893,GO:0046872,GO:0048471,GO:0070371,GO:0071902,GO:0090170,GO:0097110,GO:1903800,GO:2000641" "MAPK cascade|activation of MAPK activity|protein serine/threonine kinase activity|MAP kinase kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|MAP-kinase scaffold activity|protein binding|ATP binding|extracellular region|nucleus|mitochondrion|early endosome|late endosome|peroxisomal membrane|endoplasmic reticulum|Golgi apparatus|cytosol|microtubule|cell-cell junction|focal adhesion|cytoplasmic side of plasma membrane|negative regulation of gene expression|peptidyl-tyrosine phosphorylation|PDZ domain binding|regulation of stress-activated MAPK cascade|peptidyl-serine autophosphorylation|protein serine/threonine kinase activator activity|positive regulation of transcription, DNA-templated|metal ion binding|perinuclear region of cytoplasm|ERK1 and ERK2 cascade|positive regulation of protein serine/threonine kinase activity|regulation of Golgi inheritance|scaffold protein binding|positive regulation of production of miRNAs involved in gene silencing by miRNA|regulation of early endosome to late endosome transport" "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04066,hsa04068,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04210,hsa04218,hsa04270,hsa04370,hsa04371,hsa04540,hsa04550,hsa04620,hsa04650,hsa04660,hsa04662,hsa04664,hsa04720,hsa04722,hsa04730,hsa04810,hsa04910,hsa04912,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04929,hsa04934,hsa04935,hsa05010,hsa05022,hsa05132,hsa05135,hsa05160,hsa05161,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05170,hsa05200,hsa05205,hsa05206,hsa05210,hsa05211,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Cellular senescence|Vascular smooth muscle contraction|VEGF signaling pathway|Apelin signaling pathway|Gap junction|Signaling pathways regulating pluripotency of stem cells|Toll-like receptor signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Long-term potentiation|Neurotrophin signaling pathway|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|GnRH secretion|Cushing syndrome|Growth hormone synthesis, secretion and action|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection|Yersinia infection|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" MAP2K3 1772.301388 1764.541945 1780.060831 1.008794852 0.012632819 0.960126375 1 33.68038645 33.40804807 5606 mitogen-activated protein kinase kinase 3 "GO:0000187,GO:0001817,GO:0004674,GO:0004708,GO:0004713,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006954,GO:0007165,GO:0016020,GO:0018108,GO:0019901,GO:0035331,GO:0035924,GO:0038066,GO:0043536,GO:0045860,GO:0045893,GO:0060048" "activation of MAPK activity|regulation of cytokine production|protein serine/threonine kinase activity|MAP kinase kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleoplasm|cytosol|inflammatory response|signal transduction|membrane|peptidyl-tyrosine phosphorylation|protein kinase binding|negative regulation of hippo signaling|cellular response to vascular endothelial growth factor stimulus|p38MAPK cascade|positive regulation of blood vessel endothelial cell migration|positive regulation of protein kinase activity|positive regulation of transcription, DNA-templated|cardiac muscle contraction" "hsa04010,hsa04015,hsa04218,hsa04620,hsa04664,hsa04668,hsa04714,hsa04750,hsa04912,hsa04935,hsa05014,hsa05022,hsa05132,hsa05135,hsa05145,hsa05161,hsa05169,hsa05170,hsa05235" "MAPK signaling pathway|Rap1 signaling pathway|Cellular senescence|Toll-like receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Thermogenesis|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Growth hormone synthesis, secretion and action|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Salmonella infection|Yersinia infection|Toxoplasmosis|Hepatitis B|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer" MAP2K4 989.4441622 1058.100919 920.7874058 0.87022645 -0.200537228 0.416003613 1 13.16905348 11.26829009 6416 mitogen-activated protein kinase kinase 4 "GO:0000187,GO:0004672,GO:0004674,GO:0004708,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0006915,GO:0007165,GO:0007254,GO:0007257,GO:0008545,GO:0009611,GO:0018108,GO:0030424,GO:0031435,GO:0032839,GO:0034393,GO:0038095,GO:0043204,GO:0043525,GO:0045740,GO:0051770,GO:0061049,GO:0071260,GO:0072709,GO:2000672" activation of MAPK activity|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|cytosol|apoptotic process|signal transduction|JNK cascade|activation of JUN kinase activity|JUN kinase kinase activity|response to wounding|peptidyl-tyrosine phosphorylation|axon|mitogen-activated protein kinase kinase kinase binding|dendrite cytoplasm|positive regulation of smooth muscle cell apoptotic process|Fc-epsilon receptor signaling pathway|perikaryon|positive regulation of neuron apoptotic process|positive regulation of DNA replication|positive regulation of nitric-oxide synthase biosynthetic process|cell growth involved in cardiac muscle cell development|cellular response to mechanical stimulus|cellular response to sorbitol|negative regulation of motor neuron apoptotic process "hsa04010,hsa04012,hsa04620,hsa04664,hsa04668,hsa04912,hsa04926,hsa04935,hsa05120,hsa05132,hsa05135,hsa05142,hsa05161,hsa05166,hsa05167,hsa05169,hsa05418" "MAPK signaling pathway|ErbB signaling pathway|Toll-like receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|GnRH signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Epithelial cell signaling in Helicobacter pylori infection|Salmonella infection|Yersinia infection|Chagas disease|Hepatitis B|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Fluid shear stress and atherosclerosis" MAP2K5 321.5645748 253.8609874 389.2681622 1.533391035 0.61672565 0.045343465 1 1.394554227 2.102613773 5607 mitogen-activated protein kinase kinase 5 "GO:0000122,GO:0000187,GO:0004672,GO:0004674,GO:0004708,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005819,GO:0005829,GO:0007165,GO:0007507,GO:0018108,GO:0030307,GO:0032088,GO:0032717,GO:0034115,GO:0043154,GO:0045944,GO:0046872,GO:0050679,GO:0051247,GO:0060761,GO:0070375,GO:0071363,GO:0071499,GO:0090051,GO:2000342,GO:2001240" negative regulation of transcription by RNA polymerase II|activation of MAPK activity|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|spindle|cytosol|signal transduction|heart development|peptidyl-tyrosine phosphorylation|positive regulation of cell growth|negative regulation of NF-kappaB transcription factor activity|negative regulation of interleukin-8 production|negative regulation of heterotypic cell-cell adhesion|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of epithelial cell proliferation|positive regulation of protein metabolic process|negative regulation of response to cytokine stimulus|ERK5 cascade|cellular response to growth factor stimulus|cellular response to laminar fluid shear stress|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of chemokine (C-X-C motif) ligand 2 production|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa04010,hsa04540,hsa04722,hsa04921,hsa05418" MAPK signaling pathway|Gap junction|Neurotrophin signaling pathway|Oxytocin signaling pathway|Fluid shear stress and atherosclerosis MAP2K6 50.9953715 64.50566072 37.48508228 0.581113066 -0.783109201 0.189173876 1 0.240939849 0.137670361 5608 mitogen-activated protein kinase kinase 6 "GO:0000165,GO:0000187,GO:0002931,GO:0004674,GO:0004708,GO:0004713,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0005856,GO:0006915,GO:0006975,GO:0007050,GO:0007165,GO:0018108,GO:0019901,GO:0022602,GO:0032308,GO:0042493,GO:0043065,GO:0051770,GO:0060048,GO:0070423,GO:0072709,GO:0120163" MAPK cascade|activation of MAPK activity|response to ischemia|protein serine/threonine kinase activity|MAP kinase kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleoplasm|cytosol|cytoskeleton|apoptotic process|DNA damage induced protein phosphorylation|cell cycle arrest|signal transduction|peptidyl-tyrosine phosphorylation|protein kinase binding|ovulation cycle process|positive regulation of prostaglandin secretion|response to drug|positive regulation of apoptotic process|positive regulation of nitric-oxide synthase biosynthetic process|cardiac muscle contraction|nucleotide-binding oligomerization domain containing signaling pathway|cellular response to sorbitol|negative regulation of cold-induced thermogenesis "hsa04010,hsa04015,hsa04218,hsa04380,hsa04620,hsa04664,hsa04668,hsa04750,hsa04912,hsa04935,hsa05014,hsa05022,hsa05132,hsa05135,hsa05145,hsa05161,hsa05163,hsa05167,hsa05169,hsa05170,hsa05235,hsa05418" "MAPK signaling pathway|Rap1 signaling pathway|Cellular senescence|Osteoclast differentiation|Toll-like receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Growth hormone synthesis, secretion and action|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Salmonella infection|Yersinia infection|Toxoplasmosis|Hepatitis B|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" MAP2K7 573.6680253 551.4193578 595.9166927 1.080695997 0.111960746 0.677420409 1 8.322465402 8.843551715 5609 mitogen-activated protein kinase kinase 7 "GO:0000187,GO:0000287,GO:0004674,GO:0004708,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0006970,GO:0007165,GO:0007254,GO:0007257,GO:0008545,GO:0009408,GO:0009411,GO:0018108,GO:0019899,GO:0019901,GO:0019903,GO:0032212,GO:0034612,GO:0038095,GO:0045893,GO:0051403,GO:0051973,GO:0070374,GO:1904355" "activation of MAPK activity|magnesium ion binding|protein serine/threonine kinase activity|MAP kinase kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|apoptotic process|response to osmotic stress|signal transduction|JNK cascade|activation of JUN kinase activity|JUN kinase kinase activity|response to heat|response to UV|peptidyl-tyrosine phosphorylation|enzyme binding|protein kinase binding|protein phosphatase binding|positive regulation of telomere maintenance via telomerase|response to tumor necrosis factor|Fc-epsilon receptor signaling pathway|positive regulation of transcription, DNA-templated|stress-activated MAPK cascade|positive regulation of telomerase activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of telomere capping" "hsa04010,hsa04012,hsa04141,hsa04380,hsa04530,hsa04620,hsa04660,hsa04664,hsa04668,hsa04722,hsa04912,hsa04926,hsa05010,hsa05016,hsa05022,hsa05132,hsa05135,hsa05161,hsa05167,hsa05169,hsa05170,hsa05418" MAPK signaling pathway|ErbB signaling pathway|Protein processing in endoplasmic reticulum|Osteoclast differentiation|Tight junction|Toll-like receptor signaling pathway|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|GnRH signaling pathway|Relaxin signaling pathway|Alzheimer disease|Huntington disease|Pathways of neurodegeneration - multiple diseases|Salmonella infection|Yersinia infection|Hepatitis B|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Fluid shear stress and atherosclerosis MAP3K1 202.4655246 243.4568485 161.4742006 0.663255939 -0.592362407 0.101250382 1 1.36824395 0.89231021 4214 mitogen-activated protein kinase kinase kinase 1 "GO:0000165,GO:0000186,GO:0002755,GO:0004672,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005829,GO:0006468,GO:0008270,GO:0019901,GO:0038095,GO:0071260" MAPK cascade|activation of MAPKK activity|MyD88-dependent toll-like receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|cytosol|protein phosphorylation|zinc ion binding|protein kinase binding|Fc-epsilon receptor signaling pathway|cellular response to mechanical stimulus "hsa04010,hsa04120,hsa04530,hsa04622,hsa04722,hsa04912,hsa04935,hsa05161,hsa05166" "MAPK signaling pathway|Ubiquitin mediated proteolysis|Tight junction|RIG-I-like receptor signaling pathway|Neurotrophin signaling pathway|GnRH signaling pathway|Growth hormone synthesis, secretion and action|Hepatitis B|Human T-cell leukemia virus 1 infection" MAP3K10 292.9525786 297.5583704 288.3467868 0.969042768 -0.045367756 0.897045844 1 3.96706054 3.779922985 4294 mitogen-activated protein kinase kinase kinase 10 "GO:0003714,GO:0004672,GO:0004674,GO:0004706,GO:0005524,GO:0005737,GO:0006915,GO:0007165,GO:0007224,GO:0007254,GO:0007256,GO:0007257,GO:0018105,GO:0018107,GO:0042803,GO:0043065,GO:0043425,GO:0043433,GO:0043507,GO:0045892,GO:0046330,GO:0046777" "transcription corepressor activity|protein kinase activity|protein serine/threonine kinase activity|JUN kinase kinase kinase activity|ATP binding|cytoplasm|apoptotic process|signal transduction|smoothened signaling pathway|JNK cascade|activation of JNKK activity|activation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein homodimerization activity|positive regulation of apoptotic process|bHLH transcription factor binding|negative regulation of DNA-binding transcription factor activity|positive regulation of JUN kinase activity|negative regulation of transcription, DNA-templated|positive regulation of JNK cascade|protein autophosphorylation" "hsa05016,hsa05022" Huntington disease|Pathways of neurodegeneration - multiple diseases MAP3K11 1318.078398 1358.780531 1277.376266 0.940090203 -0.089128902 0.71301226 1 20.46729314 18.91912799 4296 mitogen-activated protein kinase kinase kinase 11 "GO:0000187,GO:0004672,GO:0004674,GO:0004706,GO:0005515,GO:0005524,GO:0005737,GO:0005813,GO:0005874,GO:0006468,GO:0007017,GO:0007254,GO:0007256,GO:0007257,GO:0008219,GO:0016020,GO:0031434,GO:0031435,GO:0042802,GO:0042803,GO:0043065,GO:0043507,GO:0043525,GO:0044843,GO:0046330,GO:0046777" activation of MAPK activity|protein kinase activity|protein serine/threonine kinase activity|JUN kinase kinase kinase activity|protein binding|ATP binding|cytoplasm|centrosome|microtubule|protein phosphorylation|microtubule-based process|JNK cascade|activation of JNKK activity|activation of JUN kinase activity|cell death|membrane|mitogen-activated protein kinase kinase binding|mitogen-activated protein kinase kinase kinase binding|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|positive regulation of JUN kinase activity|positive regulation of neuron apoptotic process|cell cycle G1/S phase transition|positive regulation of JNK cascade|protein autophosphorylation "hsa04010,hsa04932" MAPK signaling pathway|Non-alcoholic fatty liver disease MAP3K12 776.5650524 717.885579 835.2445258 1.163478624 0.218444705 0.388259335 1 6.09776125 6.975896098 7786 mitogen-activated protein kinase kinase kinase 12 "GO:0004672,GO:0004674,GO:0004706,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0007254,GO:0007256,GO:0007257,GO:0016020,GO:0016572,GO:0018105,GO:0018107,GO:0019901,GO:0030426,GO:0035556,GO:0042803,GO:0045893,GO:0046777,GO:0070374,GO:2000672" "protein kinase activity|protein serine/threonine kinase activity|JUN kinase kinase kinase activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|protein phosphorylation|JNK cascade|activation of JNKK activity|activation of JUN kinase activity|membrane|histone phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein kinase binding|growth cone|intracellular signal transduction|protein homodimerization activity|positive regulation of transcription, DNA-templated|protein autophosphorylation|positive regulation of ERK1 and ERK2 cascade|negative regulation of motor neuron apoptotic process" hsa04010 MAPK signaling pathway MAP3K13 143.2808202 127.9709076 158.5907327 1.239271767 0.309492599 0.459019666 1 1.641724071 2.000496981 9175 mitogen-activated protein kinase kinase kinase 13 "GO:0000186,GO:0004672,GO:0004674,GO:0004706,GO:0004709,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0007254,GO:0007256,GO:0007257,GO:0014042,GO:0016020,GO:0018105,GO:0019899,GO:0019901,GO:0042802,GO:0042803,GO:0045773,GO:0046777,GO:0046872,GO:0051092,GO:0106137,GO:0150012,GO:1905492" activation of MAPKK activity|protein kinase activity|protein serine/threonine kinase activity|JUN kinase kinase kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|cytoplasm|protein phosphorylation|JNK cascade|activation of JNKK activity|activation of JUN kinase activity|positive regulation of neuron maturation|membrane|peptidyl-serine phosphorylation|enzyme binding|protein kinase binding|identical protein binding|protein homodimerization activity|positive regulation of axon extension|protein autophosphorylation|metal ion binding|positive regulation of NF-kappaB transcription factor activity|IkappaB kinase complex binding|positive regulation of neuron projection arborization|positive regulation of branching morphogenesis of a nerve hsa04010 MAPK signaling pathway MAP3K14 278.8472406 318.3666481 239.327833 0.75173651 -0.411701021 0.202883086 1 3.675241807 2.716581509 9020 mitogen-activated protein kinase kinase kinase 14 "GO:0000165,GO:0000186,GO:0001650,GO:0004672,GO:0004674,GO:0004704,GO:0004709,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006468,GO:0006955,GO:0007249,GO:0016301,GO:0033209,GO:0038061,GO:0043123,GO:0043231,GO:0051607,GO:0071260" MAPK cascade|activation of MAPKK activity|fibrillar center|protein kinase activity|protein serine/threonine kinase activity|NF-kappaB-inducing kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|nucleoplasm|cytosol|protein phosphorylation|immune response|I-kappaB kinase/NF-kappaB signaling|kinase activity|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|defense response to virus|cellular response to mechanical stimulus "hsa04010,hsa04064,hsa04210,hsa04380,hsa04625,hsa04660,hsa04668,hsa04672,hsa05120,hsa05166,hsa05169" MAPK signaling pathway|NF-kappa B signaling pathway|Apoptosis|Osteoclast differentiation|C-type lectin receptor signaling pathway|T cell receptor signaling pathway|TNF signaling pathway|Intestinal immune network for IgA production|Epithelial cell signaling in Helicobacter pylori infection|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection MAP3K15 15.57160969 17.687036 13.45618338 0.760793577 -0.394423029 0.724394511 1 0.132387743 0.099034336 389840 mitogen-activated protein kinase kinase kinase 15 "GO:0000165,GO:0000186,GO:0004672,GO:0004709,GO:0005524,GO:0006468,GO:0033554,GO:0046872" MAPK cascade|activation of MAPKK activity|protein kinase activity|MAP kinase kinase kinase activity|ATP binding|protein phosphorylation|cellular response to stress|metal ion binding MAP3K2 1157.075329 1282.830317 1031.320341 0.803941353 -0.314837834 0.194752355 1 5.895315275 4.660178829 10746 mitogen-activated protein kinase kinase kinase 2 "GO:0000186,GO:0000187,GO:0004672,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006468,GO:0007257,GO:0019901,GO:0045893,GO:0046872,GO:0071260" "activation of MAPKK activity|activation of MAPK activity|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|nucleoplasm|cytosol|protein phosphorylation|activation of JUN kinase activity|protein kinase binding|positive regulation of transcription, DNA-templated|metal ion binding|cellular response to mechanical stimulus" "hsa04010,hsa04540,hsa04912" MAPK signaling pathway|Gap junction|GnRH signaling pathway MAP3K20 3670.286493 3497.871473 3842.701512 1.098582821 0.135643638 0.568481471 1 33.28726315 35.95688586 51776 mitogen-activated protein kinase kinase kinase 20 "GO:0000077,GO:0000186,GO:0000287,GO:0003723,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0007010,GO:0007050,GO:0007257,GO:0008219,GO:0030154,GO:0042733,GO:0043065,GO:0051403,GO:0060173,GO:0071480,GO:1904291" DNA damage checkpoint|activation of MAPKK activity|magnesium ion binding|RNA binding|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|protein phosphorylation|cytoskeleton organization|cell cycle arrest|activation of JUN kinase activity|cell death|cell differentiation|embryonic digit morphogenesis|positive regulation of apoptotic process|stress-activated MAPK cascade|limb development|cellular response to gamma radiation|positive regulation of mitotic DNA damage checkpoint hsa04010 MAPK signaling pathway MAP3K21 208.7872658 258.0226429 159.5518887 0.618363904 -0.693471989 0.052281603 1 4.434845161 2.696458683 84451 mitogen-activated protein kinase kinase kinase 21 "GO:0000186,GO:0004672,GO:0004709,GO:0005515,GO:0005524,GO:0005575,GO:0005737,GO:0006468,GO:0007165,GO:0007257,GO:0042803,GO:0046777" activation of MAPKK activity|protein kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|cellular_component|cytoplasm|protein phosphorylation|signal transduction|activation of JUN kinase activity|protein homodimerization activity|protein autophosphorylation MAP3K3 1243.604517 1220.405484 1266.80355 1.038018565 0.053832247 0.826526793 1 12.92021378 13.1869998 4215 mitogen-activated protein kinase kinase kinase 3 "GO:0000165,GO:0000186,GO:0001568,GO:0004672,GO:0004709,GO:0005515,GO:0005524,GO:0005829,GO:0035556,GO:0043123,GO:0046777,GO:0046872,GO:0070498,GO:0071864,GO:0090050,GO:1900745,GO:2000773" MAPK cascade|activation of MAPKK activity|blood vessel development|protein kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|cytosol|intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB signaling|protein autophosphorylation|metal ion binding|interleukin-1-mediated signaling pathway|positive regulation of cell proliferation in bone marrow|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of p38MAPK cascade|negative regulation of cellular senescence "hsa04010,hsa04722,hsa04912,hsa05166,hsa05235" MAPK signaling pathway|Neurotrophin signaling pathway|GnRH signaling pathway|Human T-cell leukemia virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer MAP3K4 778.699986 786.5528953 770.8470767 0.980032089 -0.029099108 0.913470915 1 6.936034765 6.683789067 4216 mitogen-activated protein kinase kinase kinase 4 "GO:0000165,GO:0000186,GO:0004709,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0010225,GO:0032212,GO:0035556,GO:0043507,GO:0046872,GO:0048471,GO:0051973,GO:1900745,GO:1904355" MAPK cascade|activation of MAPKK activity|MAP kinase kinase kinase activity|protein binding|ATP binding|cytoplasm|protein phosphorylation|response to UV-C|positive regulation of telomere maintenance via telomerase|intracellular signal transduction|positive regulation of JUN kinase activity|metal ion binding|perinuclear region of cytoplasm|positive regulation of telomerase activity|positive regulation of p38MAPK cascade|positive regulation of telomere capping "hsa04010,hsa04912" MAPK signaling pathway|GnRH signaling pathway MAP3K5 540.8302069 547.2577023 534.4027115 0.976510169 -0.034293026 0.905407932 1 4.463722719 4.285930832 4217 mitogen-activated protein kinase kinase kinase 5 "GO:0000165,GO:0000186,GO:0000287,GO:0002931,GO:0004672,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0007254,GO:0007257,GO:0008631,GO:0009897,GO:0010666,GO:0016032,GO:0019901,GO:0019903,GO:0019904,GO:0032991,GO:0033554,GO:0034198,GO:0034976,GO:0038066,GO:0042060,GO:0042802,GO:0042803,GO:0043065,GO:0043280,GO:0043507,GO:0045087,GO:0045663,GO:0045893,GO:0046330,GO:0051403,GO:0070059,GO:0070301,GO:0071356,GO:0072577,GO:0097190,GO:0097300,GO:1900745,GO:1901216,GO:1902170,GO:1902911,GO:1904707,GO:1990604" "MAPK cascade|activation of MAPKK activity|magnesium ion binding|response to ischemia|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|cytoplasm|cytosol|protein phosphorylation|JNK cascade|activation of JUN kinase activity|intrinsic apoptotic signaling pathway in response to oxidative stress|external side of plasma membrane|positive regulation of cardiac muscle cell apoptotic process|viral process|protein kinase binding|protein phosphatase binding|protein domain specific binding|protein-containing complex|cellular response to stress|cellular response to amino acid starvation|response to endoplasmic reticulum stress|p38MAPK cascade|wound healing|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of JUN kinase activity|innate immune response|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-templated|positive regulation of JNK cascade|stress-activated MAPK cascade|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to hydrogen peroxide|cellular response to tumor necrosis factor|endothelial cell apoptotic process|apoptotic signaling pathway|programmed necrotic cell death|positive regulation of p38MAPK cascade|positive regulation of neuron death|cellular response to reactive nitrogen species|protein kinase complex|positive regulation of vascular associated smooth muscle cell proliferation|IRE1-TRAF2-ASK1 complex" "hsa01524,hsa04010,hsa04071,hsa04141,hsa04210,hsa04530,hsa04668,hsa04714,hsa04722,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05022,hsa05418" Platinum drug resistance|MAPK signaling pathway|Sphingolipid signaling pathway|Protein processing in endoplasmic reticulum|Apoptosis|Tight junction|TNF signaling pathway|Thermogenesis|Neurotrophin signaling pathway|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Fluid shear stress and atherosclerosis MAP3K6 201.0885717 182.0724295 220.1047139 1.208885467 0.273677566 0.455254207 1 1.745127681 2.074357197 9064 mitogen-activated protein kinase kinase kinase 6 "GO:0000186,GO:0000287,GO:0004672,GO:0004709,GO:0005524,GO:0006468,GO:0007165,GO:0007257,GO:0033554" activation of MAPKK activity|magnesium ion binding|protein kinase activity|MAP kinase kinase kinase activity|ATP binding|protein phosphorylation|signal transduction|activation of JUN kinase activity|cellular response to stress hsa04010 MAPK signaling pathway MAP3K7 2077.099839 2082.908593 2071.291085 0.994422459 -0.008069215 0.975044014 1 22.461306 21.96226398 6885 mitogen-activated protein kinase kinase kinase 7 "GO:0000186,GO:0000187,GO:0000287,GO:0002223,GO:0002726,GO:0002755,GO:0004672,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005634,GO:0005671,GO:0005829,GO:0005886,GO:0007179,GO:0007223,GO:0007249,GO:0007250,GO:0007252,GO:0007254,GO:0008385,GO:0010008,GO:0016032,GO:0016239,GO:0016579,GO:0030971,GO:0032743,GO:0038095,GO:0042802,GO:0043123,GO:0043276,GO:0043507,GO:0043966,GO:0050852,GO:0051092,GO:0051403,GO:0070423,GO:0070498,GO:0097110" "activation of MAPKK activity|activation of MAPK activity|magnesium ion binding|stimulatory C-type lectin receptor signaling pathway|positive regulation of T cell cytokine production|MyD88-dependent toll-like receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|nucleus|Ada2/Gcn5/Ada3 transcription activator complex|cytosol|plasma membrane|transforming growth factor beta receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|I-kappaB kinase/NF-kappaB signaling|activation of NF-kappaB-inducing kinase activity|I-kappaB phosphorylation|JNK cascade|IkappaB kinase complex|endosome membrane|viral process|positive regulation of macroautophagy|protein deubiquitination|receptor tyrosine kinase binding|positive regulation of interleukin-2 production|Fc-epsilon receptor signaling pathway|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|anoikis|positive regulation of JUN kinase activity|histone H3 acetylation|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|scaffold protein binding" "hsa04010,hsa04064,hsa04140,hsa04152,hsa04310,hsa04380,hsa04520,hsa04620,hsa04621,hsa04622,hsa04657,hsa04660,hsa04668,hsa05130,hsa05131,hsa05132,hsa05135,hsa05140,hsa05145,hsa05161,hsa05162,hsa05168,hsa05169,hsa05170,hsa05171,hsa05418" MAPK signaling pathway|NF-kappa B signaling pathway|Autophagy - animal|AMPK signaling pathway|Wnt signaling pathway|Osteoclast differentiation|Adherens junction|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|T cell receptor signaling pathway|TNF signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Leishmaniasis|Toxoplasmosis|Hepatitis B|Measles|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Fluid shear stress and atherosclerosis MAP3K7CL 435.6540556 372.46817 498.8399412 1.339282069 0.421459841 0.136116944 1 5.100831836 6.717137505 56911 MAP3K7 C-terminal like "GO:0005515,GO:0005634,GO:0005829" protein binding|nucleus|cytosol MAP3K8 143.3053579 166.4662212 120.1444945 0.721734978 -0.47045892 0.25523853 1 1.991927416 1.413586669 1326 mitogen-activated protein kinase kinase kinase 8 "GO:0000186,GO:0000287,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005829,GO:0006468,GO:0007049,GO:0031295,GO:0051403,GO:0070498" activation of MAPKK activity|magnesium ion binding|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|cytosol|protein phosphorylation|cell cycle|T cell costimulation|stress-activated MAPK cascade|interleukin-1-mediated signaling pathway "hsa04010,hsa04620,hsa04660,hsa04668" MAPK signaling pathway|Toll-like receptor signaling pathway|T cell receptor signaling pathway|TNF signaling pathway MAP3K9 1362.058829 1340.053081 1384.064577 1.032843099 0.046621108 0.848738867 1 5.305353858 5.387904466 4293 mitogen-activated protein kinase kinase kinase 9 "GO:0004672,GO:0004674,GO:0004706,GO:0004708,GO:0005515,GO:0005524,GO:0005575,GO:0006468,GO:0006915,GO:0007256,GO:0007257,GO:0042803,GO:0043065,GO:0046777" protein kinase activity|protein serine/threonine kinase activity|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein binding|ATP binding|cellular_component|protein phosphorylation|apoptotic process|activation of JNKK activity|activation of JUN kinase activity|protein homodimerization activity|positive regulation of apoptotic process|protein autophosphorylation MAP4 9354.498229 9224.309484 9484.686974 1.028227315 0.040159243 0.872647113 1 40.25878668 40.70249179 4134 microtubule associated protein 4 "GO:0000226,GO:0003723,GO:0005198,GO:0005515,GO:0005829,GO:0005874,GO:0005875,GO:0005886,GO:0005930,GO:0007052,GO:0008017,GO:0015630,GO:0030424,GO:0031175,GO:0043005,GO:0051012,GO:0051294,GO:0051301,GO:0072686,GO:1902856" microtubule cytoskeleton organization|RNA binding|structural molecule activity|protein binding|cytosol|microtubule|microtubule associated complex|plasma membrane|axoneme|mitotic spindle organization|microtubule binding|microtubule cytoskeleton|axon|neuron projection development|neuron projection|microtubule sliding|establishment of spindle orientation|cell division|mitotic spindle|negative regulation of non-motile cilium assembly MAP4K2 1037.497544 969.6657386 1105.329349 1.139907605 0.188916891 0.441821387 1 6.811804436 7.634893802 5871 mitogen-activated protein kinase kinase kinase kinase 2 "GO:0000139,GO:0000185,GO:0004674,GO:0005515,GO:0005524,GO:0006468,GO:0006903,GO:0006955,GO:0007254,GO:0007257,GO:0008349,GO:0016323,GO:0031435,GO:0035556,GO:0045087,GO:0046330,GO:0106310,GO:0106311" Golgi membrane|activation of MAPKKK activity|protein serine/threonine kinase activity|protein binding|ATP binding|protein phosphorylation|vesicle targeting|immune response|JNK cascade|activation of JUN kinase activity|MAP kinase kinase kinase kinase activity|basolateral plasma membrane|mitogen-activated protein kinase kinase kinase binding|intracellular signal transduction|innate immune response|positive regulation of JNK cascade|protein serine kinase activity|protein threonine kinase activity hsa04010 MAPK signaling pathway MAP4K3 1025.07613 1085.15168 965.0005798 0.889277138 -0.169294998 0.49139145 1 12.31134156 10.76499138 8491 mitogen-activated protein kinase kinase kinase kinase 3 "GO:0000185,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0006468,GO:0007254,GO:0008349,GO:0009411,GO:0034612,GO:0035556,GO:0106310,GO:0106311" activation of MAPKKK activity|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|protein phosphorylation|JNK cascade|MAP kinase kinase kinase kinase activity|response to UV|response to tumor necrosis factor|intracellular signal transduction|protein serine kinase activity|protein threonine kinase activity hsa04010 MAPK signaling pathway MAP4K4 8774.781449 8577.172049 8972.390849 1.046077984 0.064990408 0.793968871 1 55.97308731 57.57242235 9448 mitogen-activated protein kinase kinase kinase kinase 4 "GO:0000165,GO:0001953,GO:0004111,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005925,GO:0006468,GO:0007165,GO:0008017,GO:0030033,GO:0030335,GO:0031098,GO:0032014,GO:0032147,GO:0035556,GO:0043066,GO:0043547,GO:0046328,GO:0048812,GO:0051549,GO:0051894,GO:0106310,GO:0106311,GO:0120183" MAPK cascade|negative regulation of cell-matrix adhesion|creatine kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|focal adhesion|protein phosphorylation|signal transduction|microtubule binding|microvillus assembly|positive regulation of cell migration|stress-activated protein kinase signaling cascade|positive regulation of ARF protein signal transduction|activation of protein kinase activity|intracellular signal transduction|negative regulation of apoptotic process|positive regulation of GTPase activity|regulation of JNK cascade|neuron projection morphogenesis|positive regulation of keratinocyte migration|positive regulation of focal adhesion assembly|protein serine kinase activity|protein threonine kinase activity|positive regulation of focal adhesion disassembly hsa04010 MAPK signaling pathway MAP4K5 2401.155394 2515.720768 2286.590019 0.908920437 -0.137774083 0.560616642 1 19.20735246 17.16581995 11183 mitogen-activated protein kinase kinase kinase kinase 5 "GO:0000185,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0007257,GO:0008349,GO:0035556,GO:0106310,GO:0106311" activation of MAPKKK activity|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|protein phosphorylation|activation of JUN kinase activity|MAP kinase kinase kinase kinase activity|intracellular signal transduction|protein serine kinase activity|protein threonine kinase activity MAP6 56.16787279 48.89945248 63.4362931 1.297280233 0.375490158 0.527087422 1 0.362203179 0.462016235 4135 microtubule associated protein 6 "GO:0000226,GO:0005515,GO:0005516,GO:0005798,GO:0005801,GO:0005874,GO:0008017,GO:0030424,GO:0030425,GO:0030658,GO:0030705,GO:0032418,GO:0048471,GO:0048813,GO:0050772,GO:0070507" microtubule cytoskeleton organization|protein binding|calmodulin binding|Golgi-associated vesicle|cis-Golgi network|microtubule|microtubule binding|axon|dendrite|transport vesicle membrane|cytoskeleton-dependent intracellular transport|lysosome localization|perinuclear region of cytoplasm|dendrite morphogenesis|positive regulation of axonogenesis|regulation of microtubule cytoskeleton organization MAP6D1 72.33894735 69.70773014 74.97016457 1.075492839 0.104997918 0.866816679 1 1.802409612 1.906040816 79929 MAP6 domain containing 1 "GO:0000226,GO:0005516,GO:0005798,GO:0005801,GO:0005874,GO:0007026,GO:0008017,GO:0018009,GO:0030705,GO:0070507" microtubule cytoskeleton organization|calmodulin binding|Golgi-associated vesicle|cis-Golgi network|microtubule|negative regulation of microtubule depolymerization|microtubule binding|N-terminal peptidyl-L-cysteine N-palmitoylation|cytoskeleton-dependent intracellular transport|regulation of microtubule cytoskeleton organization MAP7 205.1659389 200.7998793 209.5319984 1.043486675 0.061412178 0.877900359 1 2.041981804 2.095125071 9053 microtubule associated protein 7 "GO:0000226,GO:0005102,GO:0005198,GO:0005515,GO:0005829,GO:0005874,GO:0005875,GO:0006970,GO:0007163,GO:0015630,GO:0016323,GO:0030424,GO:0048471,GO:0072659" microtubule cytoskeleton organization|signaling receptor binding|structural molecule activity|protein binding|cytosol|microtubule|microtubule associated complex|response to osmotic stress|establishment or maintenance of cell polarity|microtubule cytoskeleton|basolateral plasma membrane|axon|perinuclear region of cytoplasm|protein localization to plasma membrane MAP7D1 2646.061464 2586.468912 2705.654016 1.046080238 0.064993516 0.784645965 1 40.77846148 41.9437265 55700 MAP7 domain containing 1 "GO:0000226,GO:0005819,GO:0005829,GO:0015630" microtubule cytoskeleton organization|spindle|cytosol|microtubule cytoskeleton MAP7D2 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.023232208 0.021103252 256714 MAP7 domain containing 2 "GO:0000226,GO:0015630" microtubule cytoskeleton organization|microtubule cytoskeleton MAP7D3 1067.307241 1134.051132 1000.56335 0.882291214 -0.180673176 0.46090053 1 9.31111148 8.077643081 79649 MAP7 domain containing 3 "GO:0000226,GO:0005737,GO:0005819,GO:0008017,GO:0015630,GO:0015631,GO:0016020,GO:0046785" microtubule cytoskeleton organization|cytoplasm|spindle|microtubule binding|microtubule cytoskeleton|tubulin binding|membrane|microtubule polymerization MAP9 589.7447506 607.6017075 571.8877938 0.941221505 -0.087393811 0.745407949 1 4.197616363 3.884774052 79884 microtubule associated protein 9 "GO:0000235,GO:0000281,GO:0005737,GO:0008017,GO:0030424,GO:0046602,GO:0051233,GO:0060236,GO:0072686,GO:0090307,GO:1902412,GO:1990023" astral microtubule|mitotic cytokinesis|cytoplasm|microtubule binding|axon|regulation of mitotic centrosome separation|spindle midzone|regulation of mitotic spindle organization|mitotic spindle|mitotic spindle assembly|regulation of mitotic cytokinesis|mitotic spindle midzone MAPK1 4365.86661 4234.484502 4497.248718 1.062053413 0.086856324 0.716632457 1 37.16274548 38.80836341 5594 mitogen-activated protein kinase 1 "GO:0000165,GO:0000186,GO:0000187,GO:0001784,GO:0003690,GO:0004674,GO:0004707,GO:0004708,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005769,GO:0005770,GO:0005794,GO:0005815,GO:0005829,GO:0005856,GO:0005886,GO:0005901,GO:0005925,GO:0006468,GO:0006915,GO:0006935,GO:0006974,GO:0007049,GO:0007165,GO:0007166,GO:0007268,GO:0007411,GO:0007568,GO:0007611,GO:0008134,GO:0008353,GO:0008543,GO:0009636,GO:0010468,GO:0010628,GO:0010759,GO:0010800,GO:0014066,GO:0014069,GO:0015966,GO:0016032,GO:0016301,GO:0018105,GO:0018107,GO:0019233,GO:0019858,GO:0019902,GO:0030168,GO:0030278,GO:0030424,GO:0030641,GO:0030878,GO:0031143,GO:0031435,GO:0031647,GO:0031663,GO:0032212,GO:0032839,GO:0032872,GO:0032991,GO:0033598,GO:0034198,GO:0034614,GO:0035094,GO:0035556,GO:0035578,GO:0038095,GO:0038096,GO:0038127,GO:0042307,GO:0042473,GO:0042802,GO:0043204,GO:0043312,GO:0043330,GO:0043627,GO:0045596,GO:0045727,GO:0045893,GO:0046697,GO:0048538,GO:0050852,GO:0050853,GO:0051090,GO:0051403,GO:0051493,GO:0051973,GO:0060020,GO:0060045,GO:0060291,GO:0060324,GO:0060425,GO:0060440,GO:0060716,GO:0061308,GO:0070371,GO:0070849,GO:0071276,GO:0071356,GO:0072584,GO:0072686,GO:0090170,GO:0097011,GO:0120041,GO:1900034,GO:1903351,GO:1904355,GO:1904813,GO:2000641" "MAPK cascade|activation of MAPKK activity|activation of MAPK activity|phosphotyrosine residue binding|double-stranded DNA binding|protein serine/threonine kinase activity|MAP kinase activity|MAP kinase kinase activity|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|early endosome|late endosome|Golgi apparatus|microtubule organizing center|cytosol|cytoskeleton|plasma membrane|caveola|focal adhesion|protein phosphorylation|apoptotic process|chemotaxis|cellular response to DNA damage stimulus|cell cycle|signal transduction|cell surface receptor signaling pathway|chemical synaptic transmission|axon guidance|aging|learning or memory|transcription factor binding|RNA polymerase II CTD heptapeptide repeat kinase activity|fibroblast growth factor receptor signaling pathway|response to toxic substance|regulation of gene expression|positive regulation of gene expression|positive regulation of macrophage chemotaxis|positive regulation of peptidyl-threonine phosphorylation|regulation of phosphatidylinositol 3-kinase signaling|postsynaptic density|diadenosine tetraphosphate biosynthetic process|viral process|kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|sensory perception of pain|cytosine metabolic process|phosphatase binding|platelet activation|regulation of ossification|axon|regulation of cellular pH|thyroid gland development|pseudopodium|mitogen-activated protein kinase kinase kinase binding|regulation of protein stability|lipopolysaccharide-mediated signaling pathway|positive regulation of telomere maintenance via telomerase|dendrite cytoplasm|regulation of stress-activated MAPK cascade|protein-containing complex|mammary gland epithelial cell proliferation|cellular response to amino acid starvation|cellular response to reactive oxygen species|response to nicotine|intracellular signal transduction|azurophil granule lumen|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|ERBB signaling pathway|positive regulation of protein import into nucleus|outer ear morphogenesis|identical protein binding|perikaryon|neutrophil degranulation|response to exogenous dsRNA|response to estrogen|negative regulation of cell differentiation|positive regulation of translation|positive regulation of transcription, DNA-templated|decidualization|thymus development|T cell receptor signaling pathway|B cell receptor signaling pathway|regulation of DNA-binding transcription factor activity|stress-activated MAPK cascade|regulation of cytoskeleton organization|positive regulation of telomerase activity|Bergmann glial cell differentiation|positive regulation of cardiac muscle cell proliferation|long-term synaptic potentiation|face development|lung morphogenesis|trachea formation|labyrinthine layer blood vessel development|cardiac neural crest cell development involved in heart development|ERK1 and ERK2 cascade|response to epidermal growth factor|cellular response to cadmium ion|cellular response to tumor necrosis factor|caveolin-mediated endocytosis|mitotic spindle|regulation of Golgi inheritance|cellular response to granulocyte macrophage colony-stimulating factor stimulus|positive regulation of macrophage proliferation|regulation of cellular response to heat|cellular response to dopamine|positive regulation of telomere capping|ficolin-1-rich granule lumen|regulation of early endosome to late endosome transport" "hsa01521,hsa01522,hsa01524,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04066,hsa04068,hsa04071,hsa04072,hsa04114,hsa04140,hsa04150,hsa04151,hsa04210,hsa04218,hsa04261,hsa04270,hsa04350,hsa04360,hsa04370,hsa04371,hsa04380,hsa04510,hsa04520,hsa04540,hsa04550,hsa04611,hsa04620,hsa04621,hsa04625,hsa04650,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04713,hsa04720,hsa04722,hsa04723,hsa04724,hsa04725,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04914,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04928,hsa04929,hsa04930,hsa04933,hsa04934,hsa04935,hsa04960,hsa05010,hsa05020,hsa05022,hsa05034,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05170,hsa05171,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|TGF-beta signaling pathway|Axon guidance|VEGF signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Focal adhesion|Adherens junction|Gap junction|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Type II diabetes mellitus|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" MAPK10 14.8928869 12.48496659 17.30080721 1.385731158 0.470647391 0.669945395 1 0.045920036 0.062568015 5602 mitogen-activated protein kinase 10 "GO:0000187,GO:0004705,GO:0004707,GO:0004708,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006468,GO:0007165,GO:0007254,GO:0007258,GO:0009416,GO:0010468,GO:0035556,GO:0038095,GO:0042752,GO:0048511,GO:0051090" activation of MAPK activity|JUN kinase activity|MAP kinase activity|MAP kinase kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|plasma membrane|protein phosphorylation|signal transduction|JNK cascade|JUN phosphorylation|response to light stimulus|regulation of gene expression|intracellular signal transduction|Fc-epsilon receptor signaling pathway|regulation of circadian rhythm|rhythmic process|regulation of DNA-binding transcription factor activity "hsa01522,hsa04010,hsa04012,hsa04014,hsa04024,hsa04068,hsa04071,hsa04137,hsa04140,hsa04141,hsa04210,hsa04215,hsa04217,hsa04310,hsa04380,hsa04510,hsa04530,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04664,hsa04668,hsa04722,hsa04723,hsa04728,hsa04750,hsa04910,hsa04912,hsa04914,hsa04917,hsa04920,hsa04926,hsa04930,hsa04931,hsa04932,hsa04933,hsa04935,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05142,hsa05145,hsa05152,hsa05161,hsa05162,hsa05166,hsa05167,hsa05169,hsa05170,hsa05171,hsa05200,hsa05210,hsa05212,hsa05231,hsa05418" "Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|cAMP signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Mitophagy - animal|Autophagy - animal|Protein processing in endoplasmic reticulum|Apoptosis|Apoptosis - multiple species|Necroptosis|Wnt signaling pathway|Osteoclast differentiation|Focal adhesion|Tight junction|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Adipocytokine signaling pathway|Relaxin signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis B|Measles|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Choline metabolism in cancer|Fluid shear stress and atherosclerosis" MAPK11 605.0590793 568.0659799 642.0521786 1.130242263 0.176632042 0.503630006 1 12.53789797 13.93373198 5600 mitogen-activated protein kinase 11 "GO:0000187,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0007265,GO:0010468,GO:0010628,GO:0032735,GO:0035556,GO:0045648,GO:0048010,GO:0051090,GO:0051149,GO:0051403,GO:0060044,GO:0071347,GO:0098586,GO:1901796" activation of MAPK activity|protein serine/threonine kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|Ras protein signal transduction|regulation of gene expression|positive regulation of gene expression|positive regulation of interleukin-12 production|intracellular signal transduction|positive regulation of erythrocyte differentiation|vascular endothelial growth factor receptor signaling pathway|regulation of DNA-binding transcription factor activity|positive regulation of muscle cell differentiation|stress-activated MAPK cascade|negative regulation of cardiac muscle cell proliferation|cellular response to interleukin-1|cellular response to virus|regulation of signal transduction by p53 class mediator "hsa01522,hsa04010,hsa04015,hsa04068,hsa04071,hsa04114,hsa04218,hsa04261,hsa04370,hsa04380,hsa04550,hsa04611,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04664,hsa04668,hsa04670,hsa04714,hsa04722,hsa04723,hsa04728,hsa04750,hsa04912,hsa04914,hsa04917,hsa04926,hsa04933,hsa04935,hsa05014,hsa05020,hsa05022,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05145,hsa05152,hsa05161,hsa05163,hsa05167,hsa05169,hsa05170,hsa05171,hsa05205,hsa05235,hsa05418" "Endocrine resistance|MAPK signaling pathway|Rap1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Osteoclast differentiation|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Leukocyte transendothelial migration|Thermogenesis|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Proteoglycans in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" MAPK12 842.1954153 838.5735894 845.8172413 1.008638063 0.012408575 0.965693577 1 25.17049001 24.96308193 6300 mitogen-activated protein kinase 12 "GO:0000165,GO:0000287,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006975,GO:0007050,GO:0007165,GO:0007517,GO:0010468,GO:0010952,GO:0018105,GO:0035556,GO:0045445,GO:0051149" MAPK cascade|magnesium ion binding|protein serine/threonine kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|DNA damage induced protein phosphorylation|cell cycle arrest|signal transduction|muscle organ development|regulation of gene expression|positive regulation of peptidase activity|peptidyl-serine phosphorylation|intracellular signal transduction|myoblast differentiation|positive regulation of muscle cell differentiation "hsa01522,hsa04010,hsa04015,hsa04068,hsa04071,hsa04114,hsa04218,hsa04261,hsa04370,hsa04380,hsa04550,hsa04611,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04664,hsa04668,hsa04670,hsa04714,hsa04722,hsa04723,hsa04728,hsa04750,hsa04912,hsa04914,hsa04917,hsa04926,hsa04933,hsa04935,hsa05014,hsa05020,hsa05022,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05145,hsa05152,hsa05161,hsa05163,hsa05167,hsa05169,hsa05170,hsa05171,hsa05205,hsa05235,hsa05418" "Endocrine resistance|MAPK signaling pathway|Rap1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Osteoclast differentiation|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Leukocyte transendothelial migration|Thermogenesis|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Proteoglycans in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" MAPK13 1109.261564 1074.747541 1143.775588 1.06422722 0.089806209 0.715052148 1 8.581283804 8.979616863 5603 mitogen-activated protein kinase 13 "GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006970,GO:0007049,GO:0010468,GO:0018105,GO:0032755,GO:0034644,GO:0035556,GO:0050729,GO:0051403,GO:0070301,GO:0071347,GO:0072709,GO:0072740,GO:1903936" protein serine/threonine kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|response to osmotic stress|cell cycle|regulation of gene expression|peptidyl-serine phosphorylation|positive regulation of interleukin-6 production|cellular response to UV|intracellular signal transduction|positive regulation of inflammatory response|stress-activated MAPK cascade|cellular response to hydrogen peroxide|cellular response to interleukin-1|cellular response to sorbitol|cellular response to anisomycin|cellular response to sodium arsenite "hsa01522,hsa04010,hsa04015,hsa04068,hsa04071,hsa04114,hsa04218,hsa04261,hsa04370,hsa04380,hsa04550,hsa04611,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04664,hsa04668,hsa04670,hsa04714,hsa04722,hsa04723,hsa04728,hsa04750,hsa04912,hsa04914,hsa04917,hsa04926,hsa04933,hsa04935,hsa05014,hsa05020,hsa05022,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05145,hsa05152,hsa05161,hsa05163,hsa05167,hsa05169,hsa05170,hsa05171,hsa05205,hsa05235,hsa05418" "Endocrine resistance|MAPK signaling pathway|Rap1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Osteoclast differentiation|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Leukocyte transendothelial migration|Thermogenesis|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Proteoglycans in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" MAPK14 1360.626541 1416.003294 1305.249788 0.921784429 -0.117498697 0.625963595 1 11.6673604 10.57482428 1432 mitogen-activated protein kinase 14 "GO:0000077,GO:0000187,GO:0000902,GO:0000922,GO:0001502,GO:0001525,GO:0001890,GO:0002062,GO:0004674,GO:0004707,GO:0004708,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006006,GO:0006357,GO:0006915,GO:0006935,GO:0007165,GO:0007166,GO:0007178,GO:0007265,GO:0007519,GO:0010468,GO:0010628,GO:0010831,GO:0016607,GO:0018105,GO:0019395,GO:0019899,GO:0019903,GO:0030278,GO:0030316,GO:0031281,GO:0031663,GO:0032495,GO:0032735,GO:0034774,GO:0035331,GO:0035556,GO:0035924,GO:0035994,GO:0038066,GO:0042307,GO:0042770,GO:0043312,GO:0043536,GO:0045648,GO:0045663,GO:0045944,GO:0046326,GO:0048010,GO:0048273,GO:0051090,GO:0051146,GO:0051149,GO:0051525,GO:0060045,GO:0070935,GO:0071222,GO:0071223,GO:0071356,GO:0071479,GO:0090090,GO:0090336,GO:0090400,GO:0098586,GO:0098978,GO:0099179,GO:1900015,GO:1901741,GO:1901796,GO:1904813,GO:2000379" DNA damage checkpoint|activation of MAPK activity|cell morphogenesis|spindle pole|cartilage condensation|angiogenesis|placenta development|chondrocyte differentiation|protein serine/threonine kinase activity|MAP kinase activity|MAP kinase kinase activity|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|glucose metabolic process|regulation of transcription by RNA polymerase II|apoptotic process|chemotaxis|signal transduction|cell surface receptor signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway|Ras protein signal transduction|skeletal muscle tissue development|regulation of gene expression|positive regulation of gene expression|positive regulation of myotube differentiation|nuclear speck|peptidyl-serine phosphorylation|fatty acid oxidation|enzyme binding|protein phosphatase binding|regulation of ossification|osteoclast differentiation|positive regulation of cyclase activity|lipopolysaccharide-mediated signaling pathway|response to muramyl dipeptide|positive regulation of interleukin-12 production|secretory granule lumen|negative regulation of hippo signaling|intracellular signal transduction|cellular response to vascular endothelial growth factor stimulus|response to muscle stretch|p38MAPK cascade|positive regulation of protein import into nucleus|signal transduction in response to DNA damage|neutrophil degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of erythrocyte differentiation|positive regulation of myoblast differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of glucose import|vascular endothelial growth factor receptor signaling pathway|mitogen-activated protein kinase p38 binding|regulation of DNA-binding transcription factor activity|striated muscle cell differentiation|positive regulation of muscle cell differentiation|NFAT protein binding|positive regulation of cardiac muscle cell proliferation|3'-UTR-mediated mRNA stabilization|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|cellular response to tumor necrosis factor|cellular response to ionizing radiation|negative regulation of canonical Wnt signaling pathway|positive regulation of brown fat cell differentiation|stress-induced premature senescence|cellular response to virus|glutamatergic synapse|regulation of synaptic membrane adhesion|regulation of cytokine production involved in inflammatory response|positive regulation of myoblast fusion|regulation of signal transduction by p53 class mediator|ficolin-1-rich granule lumen|positive regulation of reactive oxygen species metabolic process "hsa01522,hsa04010,hsa04015,hsa04068,hsa04071,hsa04114,hsa04218,hsa04261,hsa04370,hsa04380,hsa04550,hsa04611,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04664,hsa04668,hsa04670,hsa04714,hsa04722,hsa04723,hsa04728,hsa04750,hsa04912,hsa04914,hsa04917,hsa04926,hsa04933,hsa04935,hsa05014,hsa05020,hsa05022,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05145,hsa05152,hsa05161,hsa05163,hsa05167,hsa05169,hsa05170,hsa05171,hsa05205,hsa05235,hsa05418" "Endocrine resistance|MAPK signaling pathway|Rap1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Osteoclast differentiation|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Leukocyte transendothelial migration|Thermogenesis|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Proteoglycans in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" MAPK1IP1L 2265.678906 2201.515776 2329.842037 1.058289958 0.081734961 0.730789767 1 17.22739747 17.92650091 93487 mitogen-activated protein kinase 1 interacting protein 1 like GO:0005515 protein binding MAPK3 1517.08234 1347.335978 1686.828703 1.251973324 0.324203823 0.174141281 1 38.99395057 48.0024596 5595 mitogen-activated protein kinase 3 "GO:0000165,GO:0000186,GO:0000187,GO:0001784,GO:0001934,GO:0004674,GO:0004707,GO:0004708,GO:0005515,GO:0005524,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005739,GO:0005769,GO:0005770,GO:0005794,GO:0005829,GO:0005856,GO:0005886,GO:0005901,GO:0005925,GO:0006361,GO:0006468,GO:0006915,GO:0006975,GO:0007049,GO:0007166,GO:0007411,GO:0007568,GO:0008543,GO:0009636,GO:0010468,GO:0010628,GO:0010759,GO:0014066,GO:0016032,GO:0016310,GO:0018105,GO:0019233,GO:0019369,GO:0019902,GO:0030168,GO:0030278,GO:0030509,GO:0030641,GO:0030878,GO:0031143,GO:0031281,GO:0031663,GO:0032212,GO:0032872,GO:0032991,GO:0033129,GO:0034198,GO:0034614,GO:0035066,GO:0035556,GO:0038083,GO:0038095,GO:0038096,GO:0042473,GO:0042802,GO:0043330,GO:0045727,GO:0045944,GO:0046697,GO:0048538,GO:0051090,GO:0051216,GO:0051403,GO:0051493,GO:0051973,GO:0060020,GO:0060324,GO:0060425,GO:0060440,GO:0061308,GO:0065003,GO:0070371,GO:0070374,GO:0070498,GO:0070849,GO:0071260,GO:0071276,GO:0071356,GO:0072584,GO:0090170,GO:0097110,GO:0120041,GO:1900034,GO:1903351,GO:1904355,GO:1904417,GO:2000641,GO:2000657" MAPK cascade|activation of MAPKK activity|activation of MAPK activity|phosphotyrosine residue binding|positive regulation of protein phosphorylation|protein serine/threonine kinase activity|MAP kinase activity|MAP kinase kinase activity|protein binding|ATP binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|mitochondrion|early endosome|late endosome|Golgi apparatus|cytosol|cytoskeleton|plasma membrane|caveola|focal adhesion|transcription initiation from RNA polymerase I promoter|protein phosphorylation|apoptotic process|DNA damage induced protein phosphorylation|cell cycle|cell surface receptor signaling pathway|axon guidance|aging|fibroblast growth factor receptor signaling pathway|response to toxic substance|regulation of gene expression|positive regulation of gene expression|positive regulation of macrophage chemotaxis|regulation of phosphatidylinositol 3-kinase signaling|viral process|phosphorylation|peptidyl-serine phosphorylation|sensory perception of pain|arachidonic acid metabolic process|phosphatase binding|platelet activation|regulation of ossification|BMP signaling pathway|regulation of cellular pH|thyroid gland development|pseudopodium|positive regulation of cyclase activity|lipopolysaccharide-mediated signaling pathway|positive regulation of telomere maintenance via telomerase|regulation of stress-activated MAPK cascade|protein-containing complex|positive regulation of histone phosphorylation|cellular response to amino acid starvation|cellular response to reactive oxygen species|positive regulation of histone acetylation|intracellular signal transduction|peptidyl-tyrosine autophosphorylation|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|outer ear morphogenesis|identical protein binding|response to exogenous dsRNA|positive regulation of translation|positive regulation of transcription by RNA polymerase II|decidualization|thymus development|regulation of DNA-binding transcription factor activity|cartilage development|stress-activated MAPK cascade|regulation of cytoskeleton organization|positive regulation of telomerase activity|Bergmann glial cell differentiation|face development|lung morphogenesis|trachea formation|cardiac neural crest cell development involved in heart development|protein-containing complex assembly|ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|interleukin-1-mediated signaling pathway|response to epidermal growth factor|cellular response to mechanical stimulus|cellular response to cadmium ion|cellular response to tumor necrosis factor|caveolin-mediated endocytosis|regulation of Golgi inheritance|scaffold protein binding|positive regulation of macrophage proliferation|regulation of cellular response to heat|cellular response to dopamine|positive regulation of telomere capping|positive regulation of xenophagy|regulation of early endosome to late endosome transport|negative regulation of apolipoprotein binding "hsa01521,hsa01522,hsa01524,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04066,hsa04068,hsa04071,hsa04072,hsa04114,hsa04140,hsa04150,hsa04151,hsa04210,hsa04218,hsa04261,hsa04270,hsa04350,hsa04360,hsa04370,hsa04371,hsa04380,hsa04510,hsa04520,hsa04540,hsa04550,hsa04611,hsa04620,hsa04621,hsa04625,hsa04650,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04713,hsa04720,hsa04722,hsa04723,hsa04724,hsa04725,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04914,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04928,hsa04929,hsa04930,hsa04933,hsa04934,hsa04935,hsa04960,hsa05010,hsa05020,hsa05022,hsa05034,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05170,hsa05171,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|TGF-beta signaling pathway|Axon guidance|VEGF signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Focal adhesion|Adherens junction|Gap junction|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Type II diabetes mellitus|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Alzheimer disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" MAPK6 1323.230778 1393.114189 1253.347367 0.899673104 -0.152527201 0.526883311 1 16.83222636 14.89009535 5597 mitogen-activated protein kinase 6 "GO:0000165,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0007049,GO:0007165,GO:0010468,GO:0035556" MAPK cascade|protein serine/threonine kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|cell cycle|signal transduction|regulation of gene expression|intracellular signal transduction hsa04657 IL-17 signaling pathway MAPK7 362.7055825 324.6091314 400.8020336 1.234721993 0.304186245 0.307549784 1 4.763209441 5.782824876 5598 mitogen-activated protein kinase 7 "GO:0000165,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007049,GO:0007165,GO:0007411,GO:0010468,GO:0016605,GO:0018105,GO:0019933,GO:0034115,GO:0035556,GO:0036003,GO:0045765,GO:0045944,GO:0050728,GO:0051019,GO:0051247,GO:0051344,GO:0060761,GO:0070301,GO:0070885,GO:0071363,GO:0071499,GO:0071560,GO:1902176,GO:2000352,GO:2001240" MAPK cascade|MAP kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|cell cycle|signal transduction|axon guidance|regulation of gene expression|PML body|peptidyl-serine phosphorylation|cAMP-mediated signaling|negative regulation of heterotypic cell-cell adhesion|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter in response to stress|regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|negative regulation of inflammatory response|mitogen-activated protein kinase binding|positive regulation of protein metabolic process|negative regulation of cyclic-nucleotide phosphodiesterase activity|negative regulation of response to cytokine stimulus|cellular response to hydrogen peroxide|negative regulation of calcineurin-NFAT signaling cascade|cellular response to growth factor stimulus|cellular response to laminar fluid shear stress|cellular response to transforming growth factor beta stimulus|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|negative regulation of endothelial cell apoptotic process|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa04010,hsa04540,hsa04657,hsa04722,hsa04912,hsa04921,hsa05206,hsa05418" MAPK signaling pathway|Gap junction|IL-17 signaling pathway|Neurotrophin signaling pathway|GnRH signaling pathway|Oxytocin signaling pathway|MicroRNAs in cancer|Fluid shear stress and atherosclerosis MAPK8 1038.037258 1021.686433 1054.388084 1.032007522 0.045453486 0.856524783 1 8.797277692 8.926934379 5599 mitogen-activated protein kinase 8 "GO:0004674,GO:0004705,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006468,GO:0006979,GO:0007254,GO:0007258,GO:0009411,GO:0009612,GO:0010468,GO:0010628,GO:0016241,GO:0016301,GO:0018105,GO:0018107,GO:0019899,GO:0030424,GO:0031063,GO:0031281,GO:0032091,GO:0032880,GO:0034198,GO:0034614,GO:0035033,GO:0035556,GO:0038095,GO:0042752,GO:0042826,GO:0043065,GO:0043066,GO:0045202,GO:0048511,GO:0051090,GO:0051247,GO:0051403,GO:0071222,GO:0071260,GO:0071276,GO:0071345,GO:0090045,GO:0097441,GO:1900740,GO:1902595" protein serine/threonine kinase activity|JUN kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|protein phosphorylation|response to oxidative stress|JNK cascade|JUN phosphorylation|response to UV|response to mechanical stimulus|regulation of gene expression|positive regulation of gene expression|regulation of macroautophagy|kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|enzyme binding|axon|regulation of histone deacetylation|positive regulation of cyclase activity|negative regulation of protein binding|regulation of protein localization|cellular response to amino acid starvation|cellular response to reactive oxygen species|histone deacetylase regulator activity|intracellular signal transduction|Fc-epsilon receptor signaling pathway|regulation of circadian rhythm|histone deacetylase binding|positive regulation of apoptotic process|negative regulation of apoptotic process|synapse|rhythmic process|regulation of DNA-binding transcription factor activity|positive regulation of protein metabolic process|stress-activated MAPK cascade|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|cellular response to cadmium ion|cellular response to cytokine stimulus|positive regulation of deacetylase activity|basal dendrite|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|regulation of DNA replication origin binding "hsa01522,hsa04010,hsa04012,hsa04014,hsa04024,hsa04068,hsa04071,hsa04137,hsa04140,hsa04141,hsa04210,hsa04215,hsa04217,hsa04310,hsa04380,hsa04510,hsa04530,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04664,hsa04668,hsa04722,hsa04723,hsa04728,hsa04750,hsa04910,hsa04912,hsa04914,hsa04917,hsa04920,hsa04926,hsa04930,hsa04931,hsa04932,hsa04933,hsa04935,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05142,hsa05145,hsa05152,hsa05161,hsa05162,hsa05166,hsa05167,hsa05169,hsa05170,hsa05171,hsa05200,hsa05210,hsa05212,hsa05231,hsa05418" "Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|cAMP signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Mitophagy - animal|Autophagy - animal|Protein processing in endoplasmic reticulum|Apoptosis|Apoptosis - multiple species|Necroptosis|Wnt signaling pathway|Osteoclast differentiation|Focal adhesion|Tight junction|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Adipocytokine signaling pathway|Relaxin signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis B|Measles|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Choline metabolism in cancer|Fluid shear stress and atherosclerosis" MAPK8IP1 446.16199 433.8525891 458.471391 1.056744624 0.079626773 0.783621643 1 7.591447636 7.887980464 9479 mitogen-activated protein kinase 8 interacting protein 1 "GO:0004860,GO:0005078,GO:0005515,GO:0005634,GO:0005737,GO:0005789,GO:0005829,GO:0005886,GO:0006355,GO:0007258,GO:0008432,GO:0016192,GO:0019894,GO:0031434,GO:0031435,GO:0031966,GO:0043508,GO:0044294,GO:0044295,GO:0044297,GO:0044302,GO:0045202,GO:0046328,GO:0046330,GO:0048471,GO:2000564,GO:2001243" "protein kinase inhibitor activity|MAP-kinase scaffold activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|regulation of transcription, DNA-templated|JUN phosphorylation|JUN kinase binding|vesicle-mediated transport|kinesin binding|mitogen-activated protein kinase kinase binding|mitogen-activated protein kinase kinase kinase binding|mitochondrial membrane|negative regulation of JUN kinase activity|dendritic growth cone|axonal growth cone|cell body|dentate gyrus mossy fiber|synapse|regulation of JNK cascade|positive regulation of JNK cascade|perinuclear region of cytoplasm|regulation of CD8-positive, alpha-beta T cell proliferation|negative regulation of intrinsic apoptotic signaling pathway" hsa04010 MAPK signaling pathway MAPK8IP2 35.71122539 29.13158871 42.29086206 1.451718356 0.537761587 0.441859173 1 0.272610792 0.389131682 23542 mitogen-activated protein kinase 8 interacting protein 2 "GO:0001540,GO:0001662,GO:0005078,GO:0005198,GO:0005515,GO:0005737,GO:0007172,GO:0007254,GO:0007617,GO:0010469,GO:0014069,GO:0019894,GO:0019901,GO:0032874,GO:0032991,GO:0035176,GO:0043025,GO:0044877,GO:0046328,GO:0046958,GO:0048813,GO:0051966,GO:0060079,GO:2000310,GO:2000311,GO:2001234" "amyloid-beta binding|behavioral fear response|MAP-kinase scaffold activity|structural molecule activity|protein binding|cytoplasm|signal complex assembly|JNK cascade|mating behavior|regulation of signaling receptor activity|postsynaptic density|kinesin binding|protein kinase binding|positive regulation of stress-activated MAPK cascade|protein-containing complex|social behavior|neuronal cell body|protein-containing complex binding|regulation of JNK cascade|nonassociative learning|dendrite morphogenesis|regulation of synaptic transmission, glutamatergic|excitatory postsynaptic potential|regulation of NMDA receptor activity|regulation of AMPA receptor activity|negative regulation of apoptotic signaling pathway" hsa04010 MAPK signaling pathway MAPK8IP3 1162.357885 1093.474991 1231.24078 1.125988971 0.171192696 0.481823765 1 7.897787323 8.744012098 23162 mitogen-activated protein kinase 8 interacting protein 3 "GO:0000139,GO:0005078,GO:0005515,GO:0005737,GO:0007257,GO:0008432,GO:0016192,GO:0019894,GO:0030159,GO:0030424,GO:0030425,GO:0030426,GO:0031103,GO:0031410,GO:0044297,GO:0046328,GO:0048471,GO:0061564,GO:0099641,GO:1904115" Golgi membrane|MAP-kinase scaffold activity|protein binding|cytoplasm|activation of JUN kinase activity|JUN kinase binding|vesicle-mediated transport|kinesin binding|signaling receptor complex adaptor activity|axon|dendrite|growth cone|axon regeneration|cytoplasmic vesicle|cell body|regulation of JNK cascade|perinuclear region of cytoplasm|axon development|anterograde axonal protein transport|axon cytoplasm hsa04010 MAPK signaling pathway MAPK9 1874.194594 1638.651865 2109.737323 1.287483552 0.364554001 0.12389352 1 12.81909093 16.22819046 5601 mitogen-activated protein kinase 9 "GO:0004705,GO:0004707,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006468,GO:0007254,GO:0007258,GO:0008134,GO:0010468,GO:0010628,GO:0010744,GO:0018105,GO:0031398,GO:0034614,GO:0035556,GO:0038095,GO:0042752,GO:0048511,GO:0051090,GO:0061833,GO:0071276,GO:0071803,GO:1901485,GO:2001235" JUN kinase activity|MAP kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|protein phosphorylation|JNK cascade|JUN phosphorylation|transcription factor binding|regulation of gene expression|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|peptidyl-serine phosphorylation|positive regulation of protein ubiquitination|cellular response to reactive oxygen species|intracellular signal transduction|Fc-epsilon receptor signaling pathway|regulation of circadian rhythm|rhythmic process|regulation of DNA-binding transcription factor activity|protein localization to tricellular tight junction|cellular response to cadmium ion|positive regulation of podosome assembly|positive regulation of transcription factor catabolic process|positive regulation of apoptotic signaling pathway "hsa01522,hsa04010,hsa04012,hsa04014,hsa04024,hsa04068,hsa04071,hsa04137,hsa04140,hsa04141,hsa04210,hsa04215,hsa04217,hsa04310,hsa04380,hsa04510,hsa04530,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04664,hsa04668,hsa04722,hsa04723,hsa04728,hsa04750,hsa04910,hsa04912,hsa04914,hsa04917,hsa04920,hsa04926,hsa04930,hsa04931,hsa04932,hsa04933,hsa04935,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05142,hsa05145,hsa05152,hsa05161,hsa05162,hsa05166,hsa05167,hsa05169,hsa05170,hsa05171,hsa05200,hsa05210,hsa05212,hsa05231,hsa05418" "Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|cAMP signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Mitophagy - animal|Autophagy - animal|Protein processing in endoplasmic reticulum|Apoptosis|Apoptosis - multiple species|Necroptosis|Wnt signaling pathway|Osteoclast differentiation|Focal adhesion|Tight junction|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Adipocytokine signaling pathway|Relaxin signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis B|Measles|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Choline metabolism in cancer|Fluid shear stress and atherosclerosis" MAPKAP1 3739.886011 3508.275612 3971.49641 1.132036604 0.178920608 0.451856867 1 51.05814603 56.8324907 79109 MAPK associated protein 1 "GO:0005515,GO:0005546,GO:0005547,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0019901,GO:0021762,GO:0030950,GO:0031267,GO:0031410,GO:0031932,GO:0032148,GO:0033138,GO:0038203,GO:0043325,GO:0046580,GO:0070300,GO:0080025,GO:1900407" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|plasma membrane|protein kinase binding|substantia nigra development|establishment or maintenance of actin cytoskeleton polarity|small GTPase binding|cytoplasmic vesicle|TORC2 complex|activation of protein kinase B activity|positive regulation of peptidyl-serine phosphorylation|TORC2 signaling|phosphatidylinositol-3,4-bisphosphate binding|negative regulation of Ras protein signal transduction|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|regulation of cellular response to oxidative stress" hsa04150 mTOR signaling pathway MAPKAPK2 2048.766474 1932.04858 2165.484369 1.12082294 0.164558388 0.487248392 1 31.2928321 34.48681279 9261 MAPK activated protein kinase 2 "GO:0000165,GO:0000187,GO:0002224,GO:0004672,GO:0004674,GO:0004683,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006468,GO:0006691,GO:0006954,GO:0006974,GO:0009931,GO:0018105,GO:0032496,GO:0032675,GO:0032680,GO:0032760,GO:0034097,GO:0035556,GO:0035924,GO:0038066,GO:0043488,GO:0044351,GO:0046777,GO:0048010,GO:0048839,GO:0051019,GO:0070062,GO:0070935,GO:0106310,GO:0106311,GO:1900034" MAPK cascade|activation of MAPK activity|toll-like receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|protein binding|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|protein phosphorylation|leukotriene metabolic process|inflammatory response|cellular response to DNA damage stimulus|calcium-dependent protein serine/threonine kinase activity|peptidyl-serine phosphorylation|response to lipopolysaccharide|regulation of interleukin-6 production|regulation of tumor necrosis factor production|positive regulation of tumor necrosis factor production|response to cytokine|intracellular signal transduction|cellular response to vascular endothelial growth factor stimulus|p38MAPK cascade|regulation of mRNA stability|macropinocytosis|protein autophosphorylation|vascular endothelial growth factor receptor signaling pathway|inner ear development|mitogen-activated protein kinase binding|extracellular exosome|3'-UTR-mediated mRNA stabilization|protein serine kinase activity|protein threonine kinase activity|regulation of cellular response to heat "hsa04010,hsa04218,hsa04370,hsa04625,hsa04722,hsa05167,hsa05203" MAPK signaling pathway|Cellular senescence|VEGF signaling pathway|C-type lectin receptor signaling pathway|Neurotrophin signaling pathway|Kaposi sarcoma-associated herpesvirus infection|Viral carcinogenesis MAPKAPK3 1605.894303 1483.630197 1728.158409 1.164817495 0.220103929 0.355339396 1 25.5662308 29.28166506 7867 MAPK activated protein kinase 3 "GO:0000165,GO:0000187,GO:0002224,GO:0004674,GO:0004683,GO:0004708,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0009931,GO:0018105,GO:0032496,GO:0034097,GO:0035556,GO:0044351,GO:0046777,GO:0048010,GO:0051019,GO:0106310,GO:0106311" MAPK cascade|activation of MAPK activity|toll-like receptor signaling pathway|protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|MAP kinase kinase activity|protein binding|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|signal transduction|calcium-dependent protein serine/threonine kinase activity|peptidyl-serine phosphorylation|response to lipopolysaccharide|response to cytokine|intracellular signal transduction|macropinocytosis|protein autophosphorylation|vascular endothelial growth factor receptor signaling pathway|mitogen-activated protein kinase binding|protein serine kinase activity|protein threonine kinase activity "hsa04010,hsa04370" MAPK signaling pathway|VEGF signaling pathway MAPKAPK5 732.787797 729.3301317 736.2454623 1.009481756 0.013614838 0.963268406 1 3.51195603 3.485930491 8550 MAPK activated protein kinase 5 "GO:0000165,GO:0000187,GO:0002039,GO:0004674,GO:0004683,GO:0004708,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006417,GO:0007165,GO:0007265,GO:0009931,GO:0018105,GO:0032007,GO:0032212,GO:0035556,GO:0046777,GO:0051019,GO:0051973,GO:0090400,GO:0106310,GO:0106311,GO:1901796,GO:1904355" MAPK cascade|activation of MAPK activity|p53 binding|protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|MAP kinase kinase activity|protein binding|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of translation|signal transduction|Ras protein signal transduction|calcium-dependent protein serine/threonine kinase activity|peptidyl-serine phosphorylation|negative regulation of TOR signaling|positive regulation of telomere maintenance via telomerase|intracellular signal transduction|protein autophosphorylation|mitogen-activated protein kinase binding|positive regulation of telomerase activity|stress-induced premature senescence|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator|positive regulation of telomere capping hsa04010 MAPK signaling pathway MAPKBP1 939.8018203 915.5642167 964.0394239 1.052945721 0.074431067 0.766840356 1 6.996274271 7.243425355 23005 mitogen-activated protein kinase binding protein 1 "GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0032717,GO:0043124,GO:0097431,GO:1900425" protein binding|nucleoplasm|nucleolus|cytoplasm|negative regulation of interleukin-8 production|negative regulation of I-kappaB kinase/NF-kappaB signaling|mitotic spindle pole|negative regulation of defense response to bacterium MAPRE1 4222.715967 3882.82461 4562.607323 1.175074277 0.232751954 0.329279091 1 76.74785671 88.67531793 22919 microtubule associated protein RP/EB family member 1 "GO:0000086,GO:0001578,GO:0003723,GO:0005515,GO:0005794,GO:0005813,GO:0005815,GO:0005819,GO:0005829,GO:0005874,GO:0005881,GO:0005925,GO:0008022,GO:0008104,GO:0010389,GO:0016477,GO:0019901,GO:0030335,GO:0030981,GO:0031110,GO:0031115,GO:0031116,GO:0031253,GO:0035371,GO:0035372,GO:0036064,GO:0042802,GO:0045296,GO:0046785,GO:0051010,GO:0051225,GO:0051233,GO:0051301,GO:0071539,GO:0097711,GO:1903033,GO:1904825,GO:1905515,GO:1905721" G2/M transition of mitotic cell cycle|microtubule bundle formation|RNA binding|protein binding|Golgi apparatus|centrosome|microtubule organizing center|spindle|cytosol|microtubule|cytoplasmic microtubule|focal adhesion|protein C-terminus binding|protein localization|regulation of G2/M transition of mitotic cell cycle|cell migration|protein kinase binding|positive regulation of cell migration|cortical microtubule cytoskeleton|regulation of microtubule polymerization or depolymerization|negative regulation of microtubule polymerization|positive regulation of microtubule polymerization|cell projection membrane|microtubule plus-end|protein localization to microtubule|ciliary basal body|identical protein binding|cadherin binding|microtubule polymerization|microtubule plus-end binding|spindle assembly|spindle midzone|cell division|protein localization to centrosome|ciliary basal body-plasma membrane docking|positive regulation of microtubule plus-end binding|protein localization to microtubule plus-end|non-motile cilium assembly|mitotic spindle astral microtubule end MAPRE2 1144.606682 1018.565191 1270.648174 1.247488315 0.319026302 0.189389862 1 12.07708336 14.81391092 10982 microtubule associated protein RP/EB family member 2 "GO:0005515,GO:0005737,GO:0005815,GO:0005881,GO:0005925,GO:0008017,GO:0015630,GO:0019901,GO:0031110,GO:0032014,GO:0035371,GO:0042802,GO:0043547,GO:0051010,GO:0051225,GO:0051233,GO:0051301,GO:0051549,GO:0120183,GO:1904825" protein binding|cytoplasm|microtubule organizing center|cytoplasmic microtubule|focal adhesion|microtubule binding|microtubule cytoskeleton|protein kinase binding|regulation of microtubule polymerization or depolymerization|positive regulation of ARF protein signal transduction|microtubule plus-end|identical protein binding|positive regulation of GTPase activity|microtubule plus-end binding|spindle assembly|spindle midzone|cell division|positive regulation of keratinocyte migration|positive regulation of focal adhesion disassembly|protein localization to microtubule plus-end MAPRE3 292.4524933 246.5780902 338.3268965 1.372088235 0.45637326 0.150376454 1 5.935687633 8.00800355 22924 microtubule associated protein RP/EB family member 3 "GO:0005515,GO:0005737,GO:0005815,GO:0008017,GO:0008022,GO:0008104,GO:0019901,GO:0030496,GO:0031110,GO:0031113,GO:0035371,GO:0042802,GO:0045737,GO:0045860,GO:0045893,GO:0051010,GO:0051225,GO:0051233,GO:0051301,GO:1903033,GO:1904825,GO:1905721" "protein binding|cytoplasm|microtubule organizing center|microtubule binding|protein C-terminus binding|protein localization|protein kinase binding|midbody|regulation of microtubule polymerization or depolymerization|regulation of microtubule polymerization|microtubule plus-end|identical protein binding|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of protein kinase activity|positive regulation of transcription, DNA-templated|microtubule plus-end binding|spindle assembly|spindle midzone|cell division|positive regulation of microtubule plus-end binding|protein localization to microtubule plus-end|mitotic spindle astral microtubule end" MAPT 327.2220701 326.6899591 327.754181 1.00325759 0.00469207 0.99930468 1 2.446995465 2.413886228 4137 microtubule associated protein tau "GO:0000226,GO:0001774,GO:0003677,GO:0003680,GO:0003690,GO:0003697,GO:0003723,GO:0003779,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005874,GO:0005886,GO:0006475,GO:0006919,GO:0007267,GO:0007613,GO:0008017,GO:0010288,GO:0010506,GO:0010629,GO:0010917,GO:0015630,GO:0016020,GO:0016072,GO:0016607,GO:0017124,GO:0019896,GO:0019899,GO:0019901,GO:0021954,GO:0030424,GO:0030425,GO:0030426,GO:0030673,GO:0030674,GO:0031110,GO:0031113,GO:0031116,GO:0031122,GO:0031175,GO:0032930,GO:0033044,GO:0033673,GO:0034063,GO:0034185,GO:0034399,GO:0034452,GO:0034605,GO:0034614,GO:0035091,GO:0036464,GO:0036477,GO:0042802,GO:0043005,GO:0043025,GO:0043197,GO:0043565,GO:0044297,GO:0044304,GO:0045121,GO:0045298,GO:0045773,GO:0046785,GO:0048143,GO:0048167,GO:0048312,GO:0048699,GO:0050808,GO:0050848,GO:0051087,GO:0051258,GO:0051721,GO:0051879,GO:0061564,GO:0070507,GO:0071813,GO:0072386,GO:0090140,GO:0090258,GO:0097386,GO:0097418,GO:0097435,GO:0098930,GO:0099077,GO:0099609,GO:1900034,GO:1900452,GO:1901216,GO:1902474,GO:1902936,GO:1902988,GO:1903748,GO:1903829,GO:1904115,GO:1904428,GO:1905689,GO:1990000,GO:1990090,GO:1990416,GO:2001020" microtubule cytoskeleton organization|microglial cell activation|DNA binding|minor groove of adenine-thymine-rich DNA binding|double-stranded DNA binding|single-stranded DNA binding|RNA binding|actin binding|protein binding|extracellular region|nucleus|cytoplasm|mitochondrion|cytosol|microtubule|plasma membrane|internal protein amino acid acetylation|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell-cell signaling|memory|microtubule binding|response to lead ion|regulation of autophagy|negative regulation of gene expression|negative regulation of mitochondrial membrane potential|microtubule cytoskeleton|membrane|rRNA metabolic process|nuclear speck|SH3 domain binding|axonal transport of mitochondrion|enzyme binding|protein kinase binding|central nervous system neuron development|axon|dendrite|growth cone|axolemma|protein-macromolecule adaptor activity|regulation of microtubule polymerization or depolymerization|regulation of microtubule polymerization|positive regulation of microtubule polymerization|cytoplasmic microtubule organization|neuron projection development|positive regulation of superoxide anion generation|regulation of chromosome organization|negative regulation of kinase activity|stress granule assembly|apolipoprotein binding|nuclear periphery|dynactin binding|cellular response to heat|cellular response to reactive oxygen species|phosphatidylinositol binding|cytoplasmic ribonucleoprotein granule|somatodendritic compartment|identical protein binding|neuron projection|neuronal cell body|dendritic spine|sequence-specific DNA binding|cell body|main axon|membrane raft|tubulin complex|positive regulation of axon extension|microtubule polymerization|astrocyte activation|regulation of synaptic plasticity|intracellular distribution of mitochondria|generation of neurons|synapse organization|regulation of calcium-mediated signaling|chaperone binding|protein polymerization|protein phosphatase 2A binding|Hsp90 protein binding|axon development|regulation of microtubule cytoskeleton organization|lipoprotein particle binding|plus-end-directed organelle transport along microtubule|regulation of mitochondrial fission|negative regulation of mitochondrial fission|glial cell projection|neurofibrillary tangle|supramolecular fiber organization|axonal transport|histone-dependent DNA binding|microtubule lateral binding|regulation of cellular response to heat|regulation of long-term synaptic depression|positive regulation of neuron death|positive regulation of protein localization to synapse|phosphatidylinositol bisphosphate binding|neurofibrillary tangle assembly|negative regulation of establishment of protein localization to mitochondrion|positive regulation of cellular protein localization|axon cytoplasm|negative regulation of tubulin deacetylation|positive regulation of diacylglycerol kinase activity|amyloid fibril formation|cellular response to nerve growth factor stimulus|cellular response to brain-derived neurotrophic factor stimulus|regulation of response to DNA damage stimulus "hsa04010,hsa05010,hsa05012,hsa05022" MAPK signaling pathway|Alzheimer disease|Parkinson disease|Pathways of neurodegeneration - multiple diseases MARCHF10 9.646158105 13.52538047 5.766935736 0.426378818 -1.229792327 0.308194169 1 0.170563492 0.071507711 162333 membrane associated ring-CH-type finger 10 "GO:0005515,GO:0008270,GO:0016567,GO:0016740" protein binding|zinc ion binding|protein ubiquitination|transferase activity MARCHF2 296.242397 282.9925761 309.4922178 1.093640767 0.129138927 0.690155785 1 8.225922477 8.845664869 51257 membrane associated ring-CH-type finger 2 "GO:0004842,GO:0005515,GO:0005765,GO:0005783,GO:0005789,GO:0005829,GO:0006897,GO:0008270,GO:0010008,GO:0016021,GO:0016567,GO:0031410,GO:0061630" ubiquitin-protein transferase activity|protein binding|lysosomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|endocytosis|zinc ion binding|endosome membrane|integral component of membrane|protein ubiquitination|cytoplasmic vesicle|ubiquitin protein ligase activity MARCHF3 228.1990833 187.2744989 269.1236677 1.437054534 0.523114811 0.130801242 1 1.119455176 1.581798416 115123 membrane associated ring-CH-type finger 3 "GO:0004842,GO:0005515,GO:0005764,GO:0005768,GO:0006897,GO:0008270,GO:0016021,GO:0016567,GO:0030659,GO:0031901,GO:0043231" ubiquitin-protein transferase activity|protein binding|lysosome|endosome|endocytosis|zinc ion binding|integral component of membrane|protein ubiquitination|cytoplasmic vesicle membrane|early endosome membrane|intracellular membrane-bounded organelle MARCHF4 887.3452076 800.0782758 974.6121394 1.218145985 0.284687039 0.252674302 1 8.708690005 10.43093762 57574 membrane associated ring-CH-type finger 4 "GO:0000139,GO:0004842,GO:0005795,GO:0005802,GO:0008270,GO:0016021,GO:0016567" Golgi membrane|ubiquitin-protein transferase activity|Golgi stack|trans-Golgi network|zinc ion binding|integral component of membrane|protein ubiquitination MARCHF5 2261.002074 2179.667084 2342.337065 1.074630654 0.103840897 0.661503076 1 28.50400054 30.11869989 54708 membrane associated ring-CH-type finger 5 "GO:0000209,GO:0005515,GO:0005739,GO:0005741,GO:0005783,GO:0005789,GO:0008270,GO:0016020,GO:0016021,GO:0051020,GO:0051865,GO:0061630,GO:0070585,GO:0090140,GO:0090141,GO:0090344" protein polyubiquitination|protein binding|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|zinc ion binding|membrane|integral component of membrane|GTPase binding|protein autoubiquitination|ubiquitin protein ligase activity|protein localization to mitochondrion|regulation of mitochondrial fission|positive regulation of mitochondrial fission|negative regulation of cell aging MARCHF6 4095.223179 4030.563381 4159.882978 1.032084744 0.045561435 0.849261928 1 23.50603866 23.85426191 10299 membrane associated ring-CH-type finger 6 "GO:0000835,GO:0004842,GO:0005515,GO:0005783,GO:0005789,GO:0008270,GO:0010498,GO:0016020,GO:0016021,GO:0016567,GO:0019899,GO:0030176,GO:0030433,GO:0031624,GO:0036503,GO:0043161,GO:0044322,GO:0061630,GO:0070936,GO:1904380,GO:1990381" ER ubiquitin ligase complex|ubiquitin-protein transferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|zinc ion binding|proteasomal protein catabolic process|membrane|integral component of membrane|protein ubiquitination|enzyme binding|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|ubiquitin conjugating enzyme binding|ERAD pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|endoplasmic reticulum quality control compartment|ubiquitin protein ligase activity|protein K48-linked ubiquitination|endoplasmic reticulum mannose trimming|ubiquitin-specific protease binding hsa04141 Protein processing in endoplasmic reticulum MARCHF7 2657.08519 2560.458565 2753.711814 1.07547603 0.104975371 0.657936802 1 21.14950746 22.36516837 64844 membrane associated ring-CH-type finger 7 "GO:0002643,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0006513,GO:0008270,GO:0008284,GO:0016740,GO:0031624,GO:0042130,GO:0043130,GO:0043518,GO:0050821,GO:0051865,GO:0097371,GO:1901799,GO:1902166,GO:1902916,GO:1905524" "regulation of tolerance induction|protein binding|nucleus|cytosol|plasma membrane|protein monoubiquitination|zinc ion binding|positive regulation of cell population proliferation|transferase activity|ubiquitin conjugating enzyme binding|negative regulation of T cell proliferation|ubiquitin binding|negative regulation of DNA damage response, signal transduction by p53 class mediator|protein stabilization|protein autoubiquitination|MDM2/MDM4 family protein binding|negative regulation of proteasomal protein catabolic process|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of protein polyubiquitination|negative regulation of protein autoubiquitination" MARCHF8 752.3820537 802.1591035 702.6050038 0.875892327 -0.191174564 0.452493721 1 6.596264568 5.680936918 220972 membrane associated ring-CH-type finger 8 "GO:0000209,GO:0002250,GO:0002495,GO:0004842,GO:0005515,GO:0005737,GO:0005764,GO:0005765,GO:0005768,GO:0006955,GO:0008270,GO:0016021,GO:0030659,GO:0031901,GO:0031902,GO:0042287,GO:0061630" protein polyubiquitination|adaptive immune response|antigen processing and presentation of peptide antigen via MHC class II|ubiquitin-protein transferase activity|protein binding|cytoplasm|lysosome|lysosomal membrane|endosome|immune response|zinc ion binding|integral component of membrane|cytoplasmic vesicle membrane|early endosome membrane|late endosome membrane|MHC protein binding|ubiquitin protein ligase activity MARCHF9 571.6721002 435.9334168 707.4107836 1.622749613 0.698440412 0.008642524 0.573019799 7.804416385 12.45268851 92979 membrane associated ring-CH-type finger 9 "GO:0000139,GO:0005765,GO:0005795,GO:0005802,GO:0008270,GO:0016021,GO:0016567,GO:0016740" Golgi membrane|lysosomal membrane|Golgi stack|trans-Golgi network|zinc ion binding|integral component of membrane|protein ubiquitination|transferase activity MARCKS 2069.187909 2039.21121 2099.164608 1.029400289 0.041804092 0.861598451 1 25.33262439 25.6410407 4082 myristoylated alanine rich protein kinase C substrate "GO:0005080,GO:0005516,GO:0005737,GO:0005813,GO:0005886,GO:0005925,GO:0005938,GO:0007015,GO:0007417,GO:0015629,GO:0032432,GO:0042585,GO:0042802,GO:0051015,GO:0051017,GO:0051764,GO:0070062" protein kinase C binding|calmodulin binding|cytoplasm|centrosome|plasma membrane|focal adhesion|cell cortex|actin filament organization|central nervous system development|actin cytoskeleton|actin filament bundle|germinal vesicle|identical protein binding|actin filament binding|actin filament bundle assembly|actin crosslink formation|extracellular exosome "hsa04666,hsa05206" Fc gamma R-mediated phagocytosis|MicroRNAs in cancer MARCKSL1 1108.126801 1108.040785 1108.212817 1.000155258 0.000223973 1 1 38.2497414 37.61552298 65108 MARCKS like 1 "GO:0005515,GO:0005516,GO:0005737,GO:0005856,GO:0005886,GO:0007015,GO:0007417,GO:0008284,GO:0051015,GO:0070062" protein binding|calmodulin binding|cytoplasm|cytoskeleton|plasma membrane|actin filament organization|central nervous system development|positive regulation of cell population proliferation|actin filament binding|extracellular exosome "hsa04666,hsa05140" Fc gamma R-mediated phagocytosis|Leishmaniasis MARCOL 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.132517844 0 105378220 MARCO like "GO:0005201,GO:0005615,GO:0030198,GO:0031012" extracellular matrix structural constituent|extracellular space|extracellular matrix organization|extracellular matrix MARF1 1174.232097 1342.133909 1006.330286 0.749798719 -0.415424733 0.086691827 1 9.220805866 6.798056213 9665 meiosis regulator and mRNA stability factor 1 "GO:0003674,GO:0005515,GO:0005737,GO:0005777,GO:0005794,GO:0006302,GO:0007143,GO:0010468,GO:0010923,GO:0016020,GO:0016441,GO:0043231,GO:0048477,GO:1903231,GO:1905762" molecular_function|protein binding|cytoplasm|peroxisome|Golgi apparatus|double-strand break repair|female meiotic nuclear division|regulation of gene expression|negative regulation of phosphatase activity|membrane|posttranscriptional gene silencing|intracellular membrane-bounded organelle|oogenesis|mRNA binding involved in posttranscriptional gene silencing|CCR4-NOT complex binding MARK1 286.0263421 292.356301 279.6963832 0.956696956 -0.063866087 0.852380616 1 2.400018221 2.257668168 4139 microtubule affinity regulating kinase 1 "GO:0000226,GO:0000287,GO:0001764,GO:0001786,GO:0004674,GO:0005515,GO:0005524,GO:0005546,GO:0005737,GO:0005856,GO:0005886,GO:0006468,GO:0007010,GO:0010975,GO:0015630,GO:0016055,GO:0018105,GO:0030425,GO:0035556,GO:0048156,GO:0050321,GO:0050773,GO:0051654,GO:0070300,GO:0106310,GO:0106311" "microtubule cytoskeleton organization|magnesium ion binding|neuron migration|phosphatidylserine binding|protein serine/threonine kinase activity|protein binding|ATP binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|cytoskeleton|plasma membrane|protein phosphorylation|cytoskeleton organization|regulation of neuron projection development|microtubule cytoskeleton|Wnt signaling pathway|peptidyl-serine phosphorylation|dendrite|intracellular signal transduction|tau protein binding|tau-protein kinase activity|regulation of dendrite development|establishment of mitochondrion localization|phosphatidic acid binding|protein serine kinase activity|protein threonine kinase activity" MARK2 799.4636043 839.6140033 759.3132052 0.904359863 -0.14503113 0.566720807 1 8.574178379 7.624387709 2011 microtubule affinity regulating kinase 2 "GO:0000226,GO:0000287,GO:0000422,GO:0001764,GO:0003723,GO:0004674,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0005884,GO:0005886,GO:0006468,GO:0008289,GO:0010976,GO:0016020,GO:0016055,GO:0016328,GO:0018105,GO:0018107,GO:0030010,GO:0030295,GO:0030425,GO:0032147,GO:0035556,GO:0045197,GO:0045296,GO:0046777,GO:0048156,GO:0050321,GO:0050770,GO:0051493,GO:0051646,GO:0061564,GO:0070507,GO:0071963,GO:0097427,GO:0106310,GO:0106311,GO:1904526" microtubule cytoskeleton organization|magnesium ion binding|autophagy of mitochondrion|neuron migration|RNA binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|mitochondrion|actin filament|plasma membrane|protein phosphorylation|lipid binding|positive regulation of neuron projection development|membrane|Wnt signaling pathway|lateral plasma membrane|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|establishment of cell polarity|protein kinase activator activity|dendrite|activation of protein kinase activity|intracellular signal transduction|establishment or maintenance of epithelial cell apical/basal polarity|cadherin binding|protein autophosphorylation|tau protein binding|tau-protein kinase activity|regulation of axonogenesis|regulation of cytoskeleton organization|mitochondrion localization|axon development|regulation of microtubule cytoskeleton organization|establishment or maintenance of cell polarity regulating cell shape|microtubule bundle|protein serine kinase activity|protein threonine kinase activity|regulation of microtubule binding MARK3 2283.484829 2240.011089 2326.958569 1.038815647 0.05493965 0.817765955 1 33.06923233 33.7779878 4140 microtubule affinity regulating kinase 3 "GO:0000165,GO:0000226,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0018105,GO:0030425,GO:0032092,GO:0035331,GO:0035556,GO:0036289,GO:0048156,GO:0050321,GO:0070062,GO:0106310,GO:0106311" MAPK cascade|microtubule cytoskeleton organization|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|protein phosphorylation|peptidyl-serine phosphorylation|dendrite|positive regulation of protein binding|negative regulation of hippo signaling|intracellular signal transduction|peptidyl-serine autophosphorylation|tau protein binding|tau-protein kinase activity|extracellular exosome|protein serine kinase activity|protein threonine kinase activity MARK4 1178.300632 1183.990998 1172.610266 0.990387822 -0.01393452 0.957985447 1 17.35918228 16.90463249 57787 microtubule affinity regulating kinase 4 "GO:0000226,GO:0000930,GO:0001578,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005813,GO:0005815,GO:0005829,GO:0006468,GO:0007049,GO:0007399,GO:0008017,GO:0015630,GO:0030425,GO:0030496,GO:0035556,GO:0036064,GO:0043005,GO:0043015,GO:0043068,GO:0043130,GO:0044782,GO:0045724,GO:0046605,GO:0048156,GO:0050321,GO:0051301,GO:0097711,GO:0106310,GO:0106311,GO:1904781" microtubule cytoskeleton organization|gamma-tubulin complex|microtubule bundle formation|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|centrosome|microtubule organizing center|cytosol|protein phosphorylation|cell cycle|nervous system development|microtubule binding|microtubule cytoskeleton|dendrite|midbody|intracellular signal transduction|ciliary basal body|neuron projection|gamma-tubulin binding|positive regulation of programmed cell death|ubiquitin binding|cilium organization|positive regulation of cilium assembly|regulation of centrosome cycle|tau protein binding|tau-protein kinase activity|cell division|ciliary basal body-plasma membrane docking|protein serine kinase activity|protein threonine kinase activity|positive regulation of protein localization to centrosome MARS1 5038.32438 5802.388223 4274.260536 0.736638152 -0.440971976 0.066550635 1 110.7124759 80.19032059 4141 methionyl-tRNA synthetase 1 "GO:0000049,GO:0004825,GO:0005524,GO:0005730,GO:0005737,GO:0005829,GO:0006418,GO:0006431,GO:0009267,GO:0009303,GO:0016020,GO:0017101,GO:0032869,GO:0036120,GO:0070062,GO:0071364,GO:1901838" tRNA binding|methionine-tRNA ligase activity|ATP binding|nucleolus|cytoplasm|cytosol|tRNA aminoacylation for protein translation|methionyl-tRNA aminoacylation|cellular response to starvation|rRNA transcription|membrane|aminoacyl-tRNA synthetase multienzyme complex|cellular response to insulin stimulus|cellular response to platelet-derived growth factor stimulus|extracellular exosome|cellular response to epidermal growth factor stimulus|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I "hsa00450,hsa00970" Selenocompound metabolism|Aminoacyl-tRNA biosynthesis MARS2 199.1511685 219.5273292 178.7750078 0.814363334 -0.296255488 0.419434942 1 3.87042289 3.099187202 92935 "methionyl-tRNA synthetase 2, mitochondrial" "GO:0004825,GO:0005524,GO:0005759,GO:0006418,GO:0006431" methionine-tRNA ligase activity|ATP binding|mitochondrial matrix|tRNA aminoacylation for protein translation|methionyl-tRNA aminoacylation "hsa00450,hsa00970" Selenocompound metabolism|Aminoacyl-tRNA biosynthesis MARVELD1 2974.951752 3146.211581 2803.691924 0.891132669 -0.166287863 0.482680062 1 52.25880162 45.79024743 83742 MARVEL domain containing 1 "GO:0005634,GO:0005737,GO:0005856,GO:0005886,GO:0007049,GO:0016021,GO:0019911,GO:0042552" nucleus|cytoplasm|cytoskeleton|plasma membrane|cell cycle|integral component of membrane|structural constituent of myelin sheath|myelination MARVELD2 77.46175884 78.0310412 76.89247648 0.985408823 -0.021205706 0.995800942 1 0.902160584 0.874120838 153562 MARVEL domain containing 2 "GO:0005515,GO:0005737,GO:0005923,GO:0007605,GO:0016021,GO:0016323,GO:0016324,GO:0030054,GO:0031410,GO:0033010,GO:0043220,GO:0045216,GO:0061028,GO:0061689,GO:0070830" protein binding|cytoplasm|bicellular tight junction|sensory perception of sound|integral component of membrane|basolateral plasma membrane|apical plasma membrane|cell junction|cytoplasmic vesicle|paranodal junction|Schmidt-Lanterman incisure|cell-cell junction organization|establishment of endothelial barrier|tricellular tight junction|bicellular tight junction assembly hsa04530 Tight junction MAST1 291.5259359 260.1034707 322.9484012 1.241615117 0.312218028 0.32725549 1 2.860342918 3.492016384 22983 microtubule associated serine/threonine kinase 1 "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005856,GO:0005886,GO:0006468,GO:0007010,GO:0007420,GO:0008017,GO:0018105,GO:0030424,GO:0030425,GO:0035556,GO:0043005,GO:0043025,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytoskeleton|plasma membrane|protein phosphorylation|cytoskeleton organization|brain development|microtubule binding|peptidyl-serine phosphorylation|axon|dendrite|intracellular signal transduction|neuron projection|neuronal cell body|protein serine kinase activity|protein threonine kinase activity MAST2 3007.799632 3125.403303 2890.19596 0.924743362 -0.112875055 0.634164972 1 21.43645162 19.49150167 23139 microtubule associated serine/threonine kinase 2 "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0006468,GO:0007010,GO:0008017,GO:0015630,GO:0018105,GO:0019902,GO:0032655,GO:0035556,GO:0048515,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|plasma membrane|protein phosphorylation|cytoskeleton organization|microtubule binding|microtubule cytoskeleton|peptidyl-serine phosphorylation|phosphatase binding|regulation of interleukin-12 production|intracellular signal transduction|spermatid differentiation|protein serine kinase activity|protein threonine kinase activity MAST3 224.5029145 216.4060876 232.5997414 1.074829936 0.104108409 0.775536972 1 1.644950172 1.738455905 23031 microtubule associated serine/threonine kinase 3 "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0007010,GO:0018105,GO:0035556,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|cytoskeleton organization|peptidyl-serine phosphorylation|intracellular signal transduction|protein serine kinase activity|protein threonine kinase activity MAST4 807.5000661 773.0275148 841.9726175 1.08918842 0.123253549 0.626730927 1 1.339275993 1.434314134 375449 microtubule associated serine/threonine kinase family member 4 "GO:0000287,GO:0004674,GO:0005524,GO:0005737,GO:0007010,GO:0018105,GO:0035556,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|ATP binding|cytoplasm|cytoskeleton organization|peptidyl-serine phosphorylation|intracellular signal transduction|protein serine kinase activity|protein threonine kinase activity MASTL 1198.683052 1189.193068 1208.173037 1.015960376 0.022844136 0.928455188 1 12.25430554 12.24155684 84930 microtubule associated serine/threonine kinase like "GO:0000086,GO:0000278,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0006974,GO:0016301,GO:0018105,GO:0032154,GO:0032515,GO:0035556,GO:0051301,GO:0051721,GO:0051726,GO:0106310,GO:0106311" G2/M transition of mitotic cell cycle|mitotic cell cycle|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cellular response to DNA damage stimulus|kinase activity|peptidyl-serine phosphorylation|cleavage furrow|negative regulation of phosphoprotein phosphatase activity|intracellular signal transduction|cell division|protein phosphatase 2A binding|regulation of cell cycle|protein serine kinase activity|protein threonine kinase activity MAT1A 10.44879821 9.363724944 11.53387147 1.231761029 0.300722389 0.870906207 1 0.14767281 0.178853803 4143 methionine adenosyltransferase 1A "GO:0000096,GO:0001887,GO:0004478,GO:0005515,GO:0005524,GO:0005829,GO:0006556,GO:0006730,GO:0009087,GO:0032259,GO:0042802,GO:0046872,GO:0051289" sulfur amino acid metabolic process|selenium compound metabolic process|methionine adenosyltransferase activity|protein binding|ATP binding|cytosol|S-adenosylmethionine biosynthetic process|one-carbon metabolic process|methionine catabolic process|methylation|identical protein binding|metal ion binding|protein homotetramerization hsa00270 Cysteine and methionine metabolism MAT2A 5140.227647 5651.528211 4628.927084 0.819057591 -0.287963197 0.230918689 1 107.0683967 86.227723 4144 methionine adenosyltransferase 2A "GO:0004478,GO:0005515,GO:0005524,GO:0005829,GO:0006556,GO:0006730,GO:0032259,GO:0034214,GO:0042802,GO:0046872,GO:0048269,GO:0051291,GO:1990830" methionine adenosyltransferase activity|protein binding|ATP binding|cytosol|S-adenosylmethionine biosynthetic process|one-carbon metabolic process|methylation|protein hexamerization|identical protein binding|metal ion binding|methionine adenosyltransferase complex|protein heterooligomerization|cellular response to leukemia inhibitory factor hsa00270 Cysteine and methionine metabolism MAT2B 1797.980226 1744.774081 1851.186371 1.060989151 0.085409904 0.720284959 1 38.3980973 40.05823652 27430 methionine adenosyltransferase 2B "GO:0005515,GO:0005634,GO:0005829,GO:0006556,GO:0006730,GO:0019899,GO:0032259,GO:0048269,GO:0048270,GO:0050790,GO:0070062" protein binding|nucleus|cytosol|S-adenosylmethionine biosynthetic process|one-carbon metabolic process|enzyme binding|methylation|methionine adenosyltransferase complex|methionine adenosyltransferase regulator activity|regulation of catalytic activity|extracellular exosome hsa00270 Cysteine and methionine metabolism MATK 14.57082478 16.64662212 12.49502743 0.750604377 -0.413875392 0.719526004 1 0.306133573 0.225940055 4145 megakaryocyte-associated tyrosine kinase "GO:0004713,GO:0004715,GO:0005515,GO:0005524,GO:0005829,GO:0006468,GO:0008284,GO:0016020,GO:0018108,GO:0038128" protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|cytosol|protein phosphorylation|positive regulation of cell population proliferation|membrane|peptidyl-tyrosine phosphorylation|ERBB2 signaling pathway hsa04722 Neurotrophin signaling pathway MATN1 4.562975582 6.242483296 2.883467868 0.461910386 -1.11431511 0.584550016 1 0.086984298 0.03950661 4146 matrilin 1 "GO:0003429,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0030198,GO:0030500,GO:0031012,GO:0062023,GO:0065003" growth plate cartilage chondrocyte morphogenesis|extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|extracellular matrix organization|regulation of bone mineralization|extracellular matrix|collagen-containing extracellular matrix|protein-containing complex assembly MATN2 277.9558961 244.4972624 311.4145297 1.273693319 0.349017946 0.282045052 1 3.59657374 4.504276253 4147 matrilin 2 "GO:0005201,GO:0005509,GO:0005515,GO:0008150,GO:0031012,GO:0062023" extracellular matrix structural constituent|calcium ion binding|protein binding|biological_process|extracellular matrix|collagen-containing extracellular matrix MATN3 738.8271051 749.0979955 728.5562146 0.972577979 -0.040114168 0.879832768 1 15.63472164 14.9515344 4148 matrilin 3 "GO:0001501,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005788,GO:0030198,GO:0031012,GO:0043687,GO:0044267,GO:0051216,GO:0062023" skeletal system development|extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|endoplasmic reticulum lumen|extracellular matrix organization|extracellular matrix|post-translational protein modification|cellular protein metabolic process|cartilage development|collagen-containing extracellular matrix MATN4 2.962725795 2.080827765 3.844623824 1.847641543 0.88568489 0.829811711 1 0.046348061 0.084201623 8785 matrilin 4 "GO:0005509,GO:0005515,GO:0005576,GO:0030198,GO:0062023" calcium ion binding|protein binding|extracellular region|extracellular matrix organization|collagen-containing extracellular matrix MATR3 6339.844745 6411.030345 6268.659145 0.977792774 -0.032399351 0.894488177 1 64.30086573 61.82082867 9782 matrin 3 "GO:0002218,GO:0003170,GO:0003281,GO:0003723,GO:0003729,GO:0005198,GO:0005515,GO:0005634,GO:0005637,GO:0006417,GO:0008270,GO:0010608,GO:0016020,GO:0016363,GO:0035198,GO:0042802,GO:0045087" activation of innate immune response|heart valve development|ventricular septum development|RNA binding|mRNA binding|structural molecule activity|protein binding|nucleus|nuclear inner membrane|regulation of translation|zinc ion binding|posttranscriptional regulation of gene expression|membrane|nuclear matrix|miRNA binding|identical protein binding|innate immune response hsa05014 Amyotrophic lateral sclerosis MAU2 659.0612216 724.1280623 593.9943808 0.820289134 -0.285795578 0.269543943 1 7.440389641 6.001140801 23383 MAU2 sister chromatid cohesion factor "GO:0000785,GO:0003690,GO:0005515,GO:0005634,GO:0005654,GO:0016604,GO:0032116,GO:0034088,GO:0047485,GO:0051301,GO:0071921,GO:0090694" chromatin|double-stranded DNA binding|protein binding|nucleus|nucleoplasm|nuclear body|SMC loading complex|maintenance of mitotic sister chromatid cohesion|protein N-terminus binding|cell division|cohesin loading|Scc2-Scc4 cohesin loading complex MAVS 4493.122353 4774.459307 4211.785399 0.882149188 -0.180905432 0.449297963 1 21.49338829 18.64309882 57506 mitochondrial antiviral signaling protein "GO:0001934,GO:0002218,GO:0002230,GO:0002735,GO:0005515,GO:0005739,GO:0005741,GO:0005778,GO:0007165,GO:0016021,GO:0016032,GO:0019901,GO:0031966,GO:0032480,GO:0032727,GO:0032728,GO:0032755,GO:0032757,GO:0032760,GO:0035591,GO:0042307,GO:0042742,GO:0043123,GO:0045071,GO:0045087,GO:0045944,GO:0050700,GO:0051091,GO:0051607,GO:0060340,GO:0060760,GO:0071360,GO:0071651,GO:0071660,GO:1900063" positive regulation of protein phosphorylation|activation of innate immune response|positive regulation of defense response to virus by host|positive regulation of myeloid dendritic cell cytokine production|protein binding|mitochondrion|mitochondrial outer membrane|peroxisomal membrane|signal transduction|integral component of membrane|viral process|protein kinase binding|mitochondrial membrane|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|signaling adaptor activity|positive regulation of protein import into nucleus|defense response to bacterium|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of viral genome replication|innate immune response|positive regulation of transcription by RNA polymerase II|CARD domain binding|positive regulation of DNA-binding transcription factor activity|defense response to virus|positive regulation of type I interferon-mediated signaling pathway|positive regulation of response to cytokine stimulus|cellular response to exogenous dsRNA|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of IP-10 production|regulation of peroxisome organization "hsa04621,hsa04622,hsa04623,hsa05160,hsa05161,hsa05162,hsa05164,hsa05168,hsa05169,hsa05171" NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 MAX 1214.101177 1190.233482 1237.968871 1.040105904 0.056730431 0.817555404 1 19.96874359 20.42205684 4149 MYC associated factor X "GO:0000082,GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0009267,GO:0016605,GO:0030425,GO:0032868,GO:0032993,GO:0042802,GO:0044877,GO:0045944,GO:0046983,GO:0048678,GO:0051402,GO:0060041,GO:0065003,GO:0070317,GO:0070888,GO:0071339,GO:0071375,GO:0090575,GO:1990837" "G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|cellular response to starvation|PML body|dendrite|response to insulin|protein-DNA complex|identical protein binding|protein-containing complex binding|positive regulation of transcription by RNA polymerase II|protein dimerization activity|response to axon injury|neuron apoptotic process|retina development in camera-type eye|protein-containing complex assembly|negative regulation of G0 to G1 transition|E-box binding|MLL1 complex|cellular response to peptide hormone stimulus|RNA polymerase II transcription regulator complex|sequence-specific double-stranded DNA binding" "hsa04010,hsa05200,hsa05202,hsa05222" MAPK signaling pathway|Pathways in cancer|Transcriptional misregulation in cancer|Small cell lung cancer bHLH MAZ 1999.088305 1977.826791 2020.349819 1.021499875 0.030689027 0.898899958 1 36.84222713 37.00457086 4150 MYC associated zinc finger protein "GO:0000122,GO:0000978,GO:0000981,GO:0003700,GO:0003723,GO:0005515,GO:0005634,GO:0006357,GO:0006367,GO:0006369,GO:0008284,GO:0010628,GO:0014068,GO:0030335,GO:0045893,GO:0046872,GO:0051897,GO:2001234" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|RNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|termination of RNA polymerase II transcription|positive regulation of cell population proliferation|positive regulation of gene expression|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of cell migration|positive regulation of transcription, DNA-templated|metal ion binding|positive regulation of protein kinase B signaling|negative regulation of apoptotic signaling pathway" zf-C2H2 MB 2.080827765 4.161655531 0 0 #NAME? 0.234194363 1 0.124356051 0 4151 myoglobin "GO:0005344,GO:0005829,GO:0009725,GO:0015671,GO:0019825,GO:0020037,GO:0031444,GO:0042542,GO:0046872,GO:0070062" oxygen carrier activity|cytosol|response to hormone|oxygen transport|oxygen binding|heme binding|slow-twitch skeletal muscle fiber contraction|response to hydrogen peroxide|metal ion binding|extracellular exosome MB21D2 380.025897 375.5894116 384.4623824 1.023624124 0.033686053 0.917946571 1 6.544079855 6.586584703 151963 Mab-21 domain containing 2 "GO:0005515,GO:0044877,GO:0045296" protein binding|protein-containing complex binding|cadherin binding MBD1 1533.812636 1471.14523 1596.480043 1.085195404 0.117954843 0.62220984 1 19.53042713 20.83967137 4152 methyl-CpG binding domain protein 1 "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006366,GO:0008270,GO:0008327,GO:0010385,GO:0016363,GO:0016607,GO:0045322,GO:0045892" "DNA binding|protein binding|nucleus|nucleoplasm|chromosome|transcription by RNA polymerase II|zinc ion binding|methyl-CpG binding|double-stranded methylated DNA binding|nuclear matrix|nuclear speck|unmethylated CpG binding|negative regulation of transcription, DNA-templated" MBD2 1758.301074 1624.086071 1892.516077 1.165280653 0.220677464 0.352603477 1 15.77046737 18.06950596 8932 methyl-CpG binding domain protein 2 "GO:0000118,GO:0000122,GO:0000183,GO:0000785,GO:0000792,GO:0003696,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006346,GO:0007507,GO:0007568,GO:0008327,GO:0009612,GO:0019904,GO:0030177,GO:0031492,GO:0031667,GO:0032355,GO:0032991,GO:0034622,GO:0035197,GO:0035563,GO:0042127,GO:0042711,GO:0043044,GO:0044030,GO:0045892,GO:0048568,GO:0070742,GO:0071407" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|rDNA heterochromatin assembly|chromatin|heterochromatin|satellite DNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytosol|DNA methylation-dependent heterochromatin assembly|heart development|aging|methyl-CpG binding|response to mechanical stimulus|protein domain specific binding|positive regulation of Wnt signaling pathway|nucleosomal DNA binding|response to nutrient levels|response to estradiol|protein-containing complex|cellular protein-containing complex assembly|siRNA binding|positive regulation of chromatin binding|regulation of cell population proliferation|maternal behavior|ATP-dependent chromatin remodeling|regulation of DNA methylation|negative regulation of transcription, DNA-templated|embryonic organ development|C2H2 zinc finger domain binding|cellular response to organic cyclic compound" chromosome_remodelling_factor MBD3 771.8932508 683.5519209 860.2345806 1.258477307 0.331679202 0.189614165 1 6.424781561 7.950142878 53615 methyl-CpG binding domain protein 3 "GO:0000122,GO:0000785,GO:0000792,GO:0001701,GO:0003677,GO:0005515,GO:0005654,GO:0005737,GO:0006346,GO:0007420,GO:0007507,GO:0007568,GO:0008327,GO:0009888,GO:0016573,GO:0016581,GO:0031492,GO:0031667,GO:0032355,GO:0032991,GO:0043044,GO:0044030,GO:0048568,GO:1901796" negative regulation of transcription by RNA polymerase II|chromatin|heterochromatin|in utero embryonic development|DNA binding|protein binding|nucleoplasm|cytoplasm|DNA methylation-dependent heterochromatin assembly|brain development|heart development|aging|methyl-CpG binding|tissue development|histone acetylation|NuRD complex|nucleosomal DNA binding|response to nutrient levels|response to estradiol|protein-containing complex|ATP-dependent chromatin remodeling|regulation of DNA methylation|embryonic organ development|regulation of signal transduction by p53 class mediator MBD MBD4 797.308549 820.8865534 773.7305446 0.94255478 -0.085351627 0.738303343 1 13.13225618 12.17074393 8930 "methyl-CpG binding domain 4, DNA glycosylase" "GO:0003677,GO:0003696,GO:0004520,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0008263,GO:0016607,GO:0019104,GO:0032355,GO:0045008" DNA binding|satellite DNA binding|endodeoxyribonuclease activity|protein binding|nucleus|nucleoplasm|DNA repair|pyrimidine-specific mismatch base pair DNA N-glycosylase activity|nuclear speck|DNA N-glycosylase activity|response to estradiol|depyrimidination hsa03410 Base excision repair MBD MBD5 467.5502253 427.6101058 507.4903448 1.186806247 0.247084426 0.375396861 1 2.095378334 2.44519473 55777 methyl-CpG binding domain protein 5 "GO:0003677,GO:0003682,GO:0005634,GO:0005654,GO:0005694,GO:0007399,GO:0010369,GO:0016579,GO:0030496,GO:0040014,GO:0042593,GO:0050795,GO:0060399,GO:0070062" DNA binding|chromatin binding|nucleus|nucleoplasm|chromosome|nervous system development|chromocenter|protein deubiquitination|midbody|regulation of multicellular organism growth|glucose homeostasis|regulation of behavior|positive regulation of growth hormone receptor signaling pathway|extracellular exosome MBD6 671.7097344 740.7746844 602.6447844 0.81353318 -0.297726908 0.248482336 1 8.079661439 6.463081192 114785 methyl-CpG binding domain protein 6 "GO:0001650,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0010369,GO:0016579" fibrillar center|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|chromosome|chromocenter|protein deubiquitination MBIP 944.3157205 844.8160727 1043.815368 1.235553397 0.305157361 0.217134088 1 28.02130584 34.04247034 51562 MAP3K12 binding inhibitory protein 1 "GO:0000173,GO:0004860,GO:0005515,GO:0005654,GO:0005671,GO:0005730,GO:0005829,GO:0042802,GO:0043966" inactivation of MAPK activity involved in osmosensory signaling pathway|protein kinase inhibitor activity|protein binding|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|nucleolus|cytosol|identical protein binding|histone H3 acetylation MBLAC1 24.45978708 23.9295193 24.99005486 1.044319133 0.062562652 0.996513381 1 0.828193557 0.850425474 255374 metallo-beta-lactamase domain containing 1 "GO:0016787,GO:0046872" hydrolase activity|metal ion binding MBLAC2 179.8588523 192.4765683 167.2411363 0.868890888 -0.202753075 0.600168457 1 2.401711642 2.051905165 153364 metallo-beta-lactamase domain containing 2 "GO:0003674,GO:0005515,GO:0008150,GO:0016787,GO:0046872,GO:0070062" molecular_function|protein binding|biological_process|hydrolase activity|metal ion binding|extracellular exosome MBNL1 3035.134054 2972.462463 3097.805646 1.04216813 0.059588042 0.802396594 1 21.44004034 21.97022805 4154 muscleblind like splicing regulator 1 "GO:0000381,GO:0001701,GO:0003723,GO:0003725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006397,GO:0007399,GO:0008380,GO:0010494,GO:0030326,GO:0043484,GO:0045445,GO:0046872" "regulation of alternative mRNA splicing, via spliceosome|in utero embryonic development|RNA binding|double-stranded RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|mRNA processing|nervous system development|RNA splicing|cytoplasmic stress granule|embryonic limb morphogenesis|regulation of RNA splicing|myoblast differentiation|metal ion binding" MBNL2 1656.812989 1937.250649 1376.375329 0.710478703 -0.49313669 0.038101549 0.982059825 14.604818 10.20277695 10150 muscleblind like splicing regulator 2 "GO:0000381,GO:0003723,GO:0005654,GO:0005737,GO:0006397,GO:0008380,GO:0043484,GO:0046872,GO:1990837" "regulation of alternative mRNA splicing, via spliceosome|RNA binding|nucleoplasm|cytoplasm|mRNA processing|RNA splicing|regulation of RNA splicing|metal ion binding|sequence-specific double-stranded DNA binding" MBOAT1 251.1227872 246.5780902 255.6674843 1.036862132 0.052224077 0.887860352 1 2.318840437 2.364084837 154141 membrane bound O-acyltransferase domain containing 1 "GO:0005789,GO:0008654,GO:0010975,GO:0016020,GO:0016021,GO:0016746,GO:0030258,GO:0036150,GO:0036152,GO:0047184,GO:0106262,GO:0106263" "endoplasmic reticulum membrane|phospholipid biosynthetic process|regulation of neuron projection development|membrane|integral component of membrane|transferase activity, transferring acyl groups|lipid modification|phosphatidylserine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|1-acylglycerophosphocholine O-acyltransferase activity|1-acylglycerophosphoethanolamine O-acyltransferase activity|1-acylglycerophosphoserine O-acyltransferase activity" "hsa00561,hsa00564" Glycerolipid metabolism|Glycerophospholipid metabolism MBOAT2 2094.223852 1825.926364 2362.52134 1.293875474 0.371698775 0.116125418 1 12.50434161 15.90832625 129642 membrane bound O-acyltransferase domain containing 2 "GO:0003841,GO:0005789,GO:0008654,GO:0016020,GO:0016021,GO:0016746,GO:0030258,GO:0032330,GO:0036150,GO:0036151,GO:0036152,GO:0047184,GO:0106262,GO:0106263" "1-acylglycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum membrane|phospholipid biosynthetic process|membrane|integral component of membrane|transferase activity, transferring acyl groups|lipid modification|regulation of chondrocyte differentiation|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|1-acylglycerophosphocholine O-acyltransferase activity|1-acylglycerophosphoethanolamine O-acyltransferase activity|1-acylglycerophosphoserine O-acyltransferase activity" "hsa00561,hsa00564" Glycerolipid metabolism|Glycerophospholipid metabolism MBOAT7 1542.081842 1423.286191 1660.877492 1.166931501 0.222719877 0.350464106 1 24.97802307 28.65989564 79143 membrane bound O-acyltransferase domain containing 7 "GO:0003841,GO:0005515,GO:0005783,GO:0005789,GO:0006661,GO:0008374,GO:0016020,GO:0016021,GO:0016746,GO:0021591,GO:0021819,GO:0030258,GO:0036149,GO:0036151,GO:0044233,GO:0047144,GO:0071617,GO:0090207" "1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|phosphatidylinositol biosynthetic process|O-acyltransferase activity|membrane|integral component of membrane|transferase activity, transferring acyl groups|ventricular system development|layer formation in cerebral cortex|lipid modification|phosphatidylinositol acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|mitochondria-associated endoplasmic reticulum membrane|2-acylglycerol-3-phosphate O-acyltransferase activity|lysophospholipid acyltransferase activity|regulation of triglyceride metabolic process" hsa00564 Glycerophospholipid metabolism MBP 1086.564959 1147.576513 1025.553405 0.89366887 -0.162187725 0.507687896 1 4.471674162 3.929325066 4155 myelin basic protein "GO:0000165,GO:0002020,GO:0005515,GO:0005516,GO:0005634,GO:0005886,GO:0006955,GO:0007268,GO:0007417,GO:0007605,GO:0008366,GO:0009636,GO:0009986,GO:0019911,GO:0021762,GO:0032755,GO:0032991,GO:0033269,GO:0034115,GO:0035633,GO:0042552,GO:0043025,GO:0043209,GO:0043218,GO:0045202,GO:0061024,GO:0071944,GO:1904685,GO:2000343" MAPK cascade|protease binding|protein binding|calmodulin binding|nucleus|plasma membrane|immune response|chemical synaptic transmission|central nervous system development|sensory perception of sound|axon ensheathment|response to toxic substance|cell surface|structural constituent of myelin sheath|substantia nigra development|positive regulation of interleukin-6 production|protein-containing complex|internode region of axon|negative regulation of heterotypic cell-cell adhesion|maintenance of blood-brain barrier|myelination|neuronal cell body|myelin sheath|compact myelin|synapse|membrane organization|cell periphery|positive regulation of metalloendopeptidase activity|positive regulation of chemokine (C-X-C motif) ligand 2 production MBTD1 398.3469964 427.6101058 369.0838871 0.863131816 -0.212347193 0.466170539 1 3.895658148 3.306200168 54799 mbt domain containing 1 "GO:0003682,GO:0005515,GO:0005634,GO:0006325,GO:0008270,GO:0035064,GO:0042393,GO:0045892,GO:0048706" "chromatin binding|protein binding|nucleus|chromatin organization|zinc ion binding|methylated histone binding|histone binding|negative regulation of transcription, DNA-templated|embryonic skeletal system development" MBTPS1 3621.785903 3801.672327 3441.899478 0.905364582 -0.143429225 0.546292371 1 39.12984859 34.83395985 8720 "membrane bound transcription factor peptidase, site 1" "GO:0000139,GO:0004252,GO:0005788,GO:0005789,GO:0005794,GO:0005795,GO:0006508,GO:0006606,GO:0007040,GO:0008203,GO:0016021,GO:0030968,GO:0031293,GO:0034976,GO:0036500,GO:0043687,GO:0044267,GO:0045540,GO:0060627" Golgi membrane|serine-type endopeptidase activity|endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi apparatus|Golgi stack|proteolysis|protein import into nucleus|lysosome organization|cholesterol metabolic process|integral component of membrane|endoplasmic reticulum unfolded protein response|membrane protein intracellular domain proteolysis|response to endoplasmic reticulum stress|ATF6-mediated unfolded protein response|post-translational protein modification|cellular protein metabolic process|regulation of cholesterol biosynthetic process|regulation of vesicle-mediated transport hsa04141 Protein processing in endoplasmic reticulum MBTPS2 1084.860913 1102.838716 1066.883111 0.967397223 -0.047819698 0.848153933 1 13.23807362 12.59217664 51360 "membrane bound transcription factor peptidase, site 2" "GO:0000139,GO:0004222,GO:0005737,GO:0005789,GO:0008203,GO:0016021,GO:0030968,GO:0031293,GO:0034976,GO:0036500,GO:0045540,GO:0046872,GO:0051091,GO:0070977,GO:1905897,GO:1990440" Golgi membrane|metalloendopeptidase activity|cytoplasm|endoplasmic reticulum membrane|cholesterol metabolic process|integral component of membrane|endoplasmic reticulum unfolded protein response|membrane protein intracellular domain proteolysis|response to endoplasmic reticulum stress|ATF6-mediated unfolded protein response|regulation of cholesterol biosynthetic process|metal ion binding|positive regulation of DNA-binding transcription factor activity|bone maturation|regulation of response to endoplasmic reticulum stress|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress hsa04141 Protein processing in endoplasmic reticulum MC1R 18.49470653 18.72744989 18.26196316 0.975144148 -0.036312598 1 1 0.473448404 0.453954844 4157 melanocortin 1 receptor "GO:0004930,GO:0004977,GO:0004980,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007187,GO:0007189,GO:0007275,GO:0008528,GO:0009650,GO:0010739,GO:0019222,GO:0031625,GO:0032720,GO:0035556,GO:0043473,GO:0045944,GO:0051897,GO:0070914,GO:0090037" "G protein-coupled receptor activity|melanocortin receptor activity|melanocyte-stimulating hormone receptor activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-activating G protein-coupled receptor signaling pathway|multicellular organism development|G protein-coupled peptide receptor activity|UV protection|positive regulation of protein kinase A signaling|regulation of metabolic process|ubiquitin protein ligase binding|negative regulation of tumor necrosis factor production|intracellular signal transduction|pigmentation|positive regulation of transcription by RNA polymerase II|positive regulation of protein kinase B signaling|UV-damage excision repair|positive regulation of protein kinase C signaling" "hsa04080,hsa04916" Neuroactive ligand-receptor interaction|Melanogenesis MC4R 4.523346619 5.202069413 3.844623824 0.739056617 -0.436243205 0.933440272 1 0.161974845 0.11770542 4160 melanocortin 4 receptor "GO:0002024,GO:0004930,GO:0004977,GO:0004980,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0006112,GO:0007186,GO:0007188,GO:0007189,GO:0007631,GO:0016021,GO:0017046,GO:0019222,GO:0031625,GO:0042923,GO:0045780,GO:2000252,GO:2000821" diet induced thermogenesis|G protein-coupled receptor activity|melanocortin receptor activity|melanocyte-stimulating hormone receptor activity|protein binding|nucleus|cytoplasm|plasma membrane|energy reserve metabolic process|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|feeding behavior|integral component of membrane|peptide hormone binding|regulation of metabolic process|ubiquitin protein ligase binding|neuropeptide binding|positive regulation of bone resorption|negative regulation of feeding behavior|regulation of grooming behavior hsa04080 Neuroactive ligand-receptor interaction MCAM 3921.440192 4363.495824 3479.384561 0.797384643 -0.326652274 0.170016884 1 38.19448128 29.94605805 4162 melanoma cell adhesion molecule "GO:0001525,GO:0003094,GO:0005576,GO:0005615,GO:0005634,GO:0005886,GO:0005925,GO:0007155,GO:0009653,GO:0009897,GO:0016021,GO:0030335,GO:0061042" angiogenesis|glomerular filtration|extracellular region|extracellular space|nucleus|plasma membrane|focal adhesion|cell adhesion|anatomical structure morphogenesis|external side of plasma membrane|integral component of membrane|positive regulation of cell migration|vascular wound healing MCAT 289.5193357 270.5076095 308.5310619 1.140563337 0.189746564 0.55784647 1 6.894218695 7.731711522 27349 malonyl-CoA-acyl carrier protein transacylase "GO:0003723,GO:0004312,GO:0004314,GO:0005739,GO:0005759,GO:0006633,GO:0006635" RNA binding|fatty acid synthase activity|[acyl-carrier-protein] S-malonyltransferase activity|mitochondrion|mitochondrial matrix|fatty acid biosynthetic process|fatty acid beta-oxidation hsa00061 Fatty acid biosynthesis MCC 710.1113133 752.2192372 668.0033894 0.88804348 -0.171297779 0.504923632 1 1.504048487 1.313309984 4163 MCC regulator of WNT signaling pathway "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0010633,GO:0016055,GO:0030027,GO:0036464,GO:0038023,GO:0045184,GO:0050680,GO:0090090" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|signal transduction|negative regulation of epithelial cell migration|Wnt signaling pathway|lamellipodium|cytoplasmic ribonucleoprotein granule|signaling receptor activity|establishment of protein localization|negative regulation of epithelial cell proliferation|negative regulation of canonical Wnt signaling pathway MCCC1 556.7534468 586.7934298 526.7134639 0.89761309 -0.155834379 0.562517527 1 9.52435732 8.406128727 56922 methylcrotonoyl-CoA carboxylase 1 "GO:0002169,GO:0004075,GO:0004485,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0005829,GO:0006552,GO:0006768,GO:0009083,GO:0009374,GO:0016421,GO:0046872,GO:1905202" "3-methylcrotonyl-CoA carboxylase complex, mitochondrial|biotin carboxylase activity|methylcrotonoyl-CoA carboxylase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|cytosol|leucine catabolic process|biotin metabolic process|branched-chain amino acid catabolic process|biotin binding|CoA carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase complex" hsa00280 "Valine, leucine and isoleucine degradation" MCCC2 1105.748449 1146.536099 1064.960799 0.928850649 -0.106481452 0.664435946 1 14.5134071 13.25520488 64087 methylcrotonoyl-CoA carboxylase 2 "GO:0002169,GO:0004485,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0005829,GO:0006552,GO:0006768,GO:0009083,GO:0015936,GO:1905202" "3-methylcrotonyl-CoA carboxylase complex, mitochondrial|methylcrotonoyl-CoA carboxylase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|cytosol|leucine catabolic process|biotin metabolic process|branched-chain amino acid catabolic process|coenzyme A metabolic process|methylcrotonoyl-CoA carboxylase complex" hsa00280 "Valine, leucine and isoleucine degradation" MCEE 95.03996879 85.31393838 104.7659992 1.22800566 0.29631721 0.544243392 1 5.505499505 6.64765198 84693 methylmalonyl-CoA epimerase "GO:0004493,GO:0005515,GO:0005759,GO:0019626,GO:0046491,GO:0046872" methylmalonyl-CoA epimerase activity|protein binding|mitochondrial matrix|short-chain fatty acid catabolic process|L-methylmalonyl-CoA metabolic process|metal ion binding "hsa00280,hsa00630,hsa00640" "Valine, leucine and isoleucine degradation|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism" MCF2L2 132.3564744 106.122216 158.5907327 1.494415954 0.579581762 0.172864815 1 0.459144518 0.674671053 23101 MCF.2 cell line derived transforming sequence-like 2 "GO:0005085,GO:0050790" guanyl-nucleotide exchange factor activity|regulation of catalytic activity MCFD2 8154.199221 8169.329807 8139.068635 0.996295758 -0.005354013 0.983257173 1 97.86355043 95.86949234 90411 "multiple coagulation factor deficiency 2, ER cargo receptor complex subunit" "GO:0000139,GO:0005509,GO:0005515,GO:0005789,GO:0006888,GO:0012507,GO:0015031,GO:0018279,GO:0033116,GO:0048208" Golgi membrane|calcium ion binding|protein binding|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|ER to Golgi transport vesicle membrane|protein transport|protein N-linked glycosylation via asparagine|endoplasmic reticulum-Golgi intermediate compartment membrane|COPII vesicle coating MCIDAS 58.44684537 58.26317743 58.63051332 1.006304769 0.009067306 1 1 1.068521889 1.057265675 345643 multiciliate differentiation and DNA synthesis associated cell cycle protein "GO:0003713,GO:0005515,GO:0005634,GO:0005730,GO:0007049,GO:0007346,GO:0008156,GO:0016604,GO:0042802,GO:0044458,GO:0045786,GO:0045944,GO:0060271,GO:0098534,GO:1902017,GO:1903251" transcription coactivator activity|protein binding|nucleus|nucleolus|cell cycle|regulation of mitotic cell cycle|negative regulation of DNA replication|nuclear body|identical protein binding|motile cilium assembly|negative regulation of cell cycle|positive regulation of transcription by RNA polymerase II|cilium assembly|centriole assembly|regulation of cilium assembly|multi-ciliated epithelial cell differentiation MCL1 10878.60668 9633.192139 12124.02123 1.258567363 0.331782437 0.190528652 1 130.1533568 161.0656827 4170 "MCL1 apoptosis regulator, BCL2 family member" "GO:0001709,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005829,GO:0007275,GO:0008320,GO:0008630,GO:0010507,GO:0016020,GO:0016021,GO:0019221,GO:0019725,GO:0034097,GO:0042803,GO:0043066,GO:0046982,GO:0051434,GO:0071806,GO:0097136,GO:0097192,GO:1903378,GO:2000811,GO:2001020,GO:2001240,GO:2001243" cell fate determination|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|cytosol|multicellular organism development|protein transmembrane transporter activity|intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of autophagy|membrane|integral component of membrane|cytokine-mediated signaling pathway|cellular homeostasis|response to cytokine|protein homodimerization activity|negative regulation of apoptotic process|protein heterodimerization activity|BH3 domain binding|protein transmembrane transport|Bcl-2 family protein complex|extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|negative regulation of anoikis|regulation of response to DNA damage stimulus|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of intrinsic apoptotic signaling pathway "hsa04151,hsa04210,hsa04630,hsa05206" PI3K-Akt signaling pathway|Apoptosis|JAK-STAT signaling pathway|MicroRNAs in cancer MCM10 482.7544991 561.8234966 403.6855015 0.718527267 -0.476885189 0.083306551 1 6.553767744 4.630261069 55388 minichromosome maintenance 10 replication initiation factor "GO:0000082,GO:0003688,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006260,GO:0006270,GO:0006974,GO:0008283,GO:0019899,GO:0031298,GO:0042802,GO:0046872" G1/S transition of mitotic cell cycle|DNA replication origin binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|nucleolus|DNA replication|DNA replication initiation|cellular response to DNA damage stimulus|cell population proliferation|enzyme binding|replication fork protection complex|identical protein binding|metal ion binding MCM2 2475.872079 2647.853331 2303.890827 0.870097599 -0.200750857 0.395951593 1 40.11100362 34.31647555 4171 minichromosome maintenance complex component 2 "GO:0000082,GO:0000727,GO:0000781,GO:0000785,GO:0003677,GO:0003688,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005664,GO:0005730,GO:0005737,GO:0006260,GO:0006267,GO:0006268,GO:0006270,GO:0006334,GO:0006915,GO:0017116,GO:0019899,GO:0042393,GO:0042555,GO:0043138,GO:0046872,GO:0071162,GO:0071353,GO:0090102,GO:1902975,GO:1905775" "G1/S transition of mitotic cell cycle|double-strand break repair via break-induced replication|chromosome, telomeric region|chromatin|DNA binding|DNA replication origin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|nuclear origin of replication recognition complex|nucleolus|cytoplasm|DNA replication|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|DNA unwinding involved in DNA replication|DNA replication initiation|nucleosome assembly|apoptotic process|single-stranded DNA helicase activity|enzyme binding|histone binding|MCM complex|3'-5' DNA helicase activity|metal ion binding|CMG complex|cellular response to interleukin-4|cochlea development|mitotic DNA replication initiation|negative regulation of DNA helicase activity" "hsa03030,hsa04110" DNA replication|Cell cycle MCM3 1699.675591 1611.601104 1787.750078 1.109300604 0.149650367 0.529505359 1 25.6511151 27.97864497 4172 minichromosome maintenance complex component 3 "GO:0000082,GO:0000727,GO:0000781,GO:0003677,GO:0003678,GO:0003688,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005658,GO:0005730,GO:0005813,GO:0006260,GO:0006267,GO:0006270,GO:0006271,GO:0016020,GO:0032508,GO:0042555,GO:0048471,GO:0071162,GO:1902975" "G1/S transition of mitotic cell cycle|double-strand break repair via break-induced replication|chromosome, telomeric region|DNA binding|DNA helicase activity|DNA replication origin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|alpha DNA polymerase:primase complex|nucleolus|centrosome|DNA replication|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|DNA replication initiation|DNA strand elongation involved in DNA replication|membrane|DNA duplex unwinding|MCM complex|perinuclear region of cytoplasm|CMG complex|mitotic DNA replication initiation" "hsa03030,hsa04110" DNA replication|Cell cycle MCM3AP 1749.857647 1806.1585 1693.556794 0.937656797 -0.092868133 0.697024243 1 13.76036539 12.68659428 8888 minichromosome maintenance complex component 3 associated protein "GO:0003676,GO:0003682,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0006406,GO:0010484,GO:0016446,GO:0016973,GO:0031965,GO:0034728,GO:0042393,GO:0043966,GO:0044615,GO:0070390" nucleic acid binding|chromatin binding|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|cytosol|mRNA export from nucleus|H3 histone acetyltransferase activity|somatic hypermutation of immunoglobulin genes|poly(A)+ mRNA export from nucleus|nuclear membrane|nucleosome organization|histone binding|histone H3 acetylation|nuclear pore nuclear basket|transcription export complex 2 MCM4 4766.321545 5095.947197 4436.695893 0.870632234 -0.19986466 0.404217414 1 66.95256917 57.31564284 4173 minichromosome maintenance complex component 4 "GO:0000082,GO:0000727,GO:0000781,GO:0003678,GO:0003688,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006260,GO:0006267,GO:0006268,GO:0006271,GO:0016020,GO:0042555,GO:0071162,GO:1902975" "G1/S transition of mitotic cell cycle|double-strand break repair via break-induced replication|chromosome, telomeric region|DNA helicase activity|DNA replication origin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|DNA replication|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|DNA unwinding involved in DNA replication|DNA strand elongation involved in DNA replication|membrane|MCM complex|CMG complex|mitotic DNA replication initiation" "hsa03030,hsa04110" DNA replication|Cell cycle MCM5 2005.187364 1948.695202 2061.679526 1.057979474 0.081311638 0.732582691 1 25.34071184 26.36132474 4174 minichromosome maintenance complex component 5 "GO:0000082,GO:0000727,GO:0000781,GO:0003688,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006260,GO:0006267,GO:0006270,GO:0016020,GO:0017116,GO:0032508,GO:0042555,GO:0043138,GO:0071162" "G1/S transition of mitotic cell cycle|double-strand break repair via break-induced replication|chromosome, telomeric region|DNA replication origin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|DNA replication|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|DNA replication initiation|membrane|single-stranded DNA helicase activity|DNA duplex unwinding|MCM complex|3'-5' DNA helicase activity|CMG complex" "hsa03030,hsa04110" DNA replication|Cell cycle MCM6 1303.147725 1042.49471 1563.80074 1.500056283 0.585016633 0.015198946 0.71670894 14.82441425 21.86534203 4175 minichromosome maintenance complex component 6 "GO:0000082,GO:0000727,GO:0000781,GO:0003678,GO:0003688,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006260,GO:0006267,GO:0006268,GO:0006270,GO:0042555,GO:0042802,GO:0071162,GO:1902969,GO:1990518" "G1/S transition of mitotic cell cycle|double-strand break repair via break-induced replication|chromosome, telomeric region|DNA helicase activity|DNA replication origin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|DNA replication|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|DNA unwinding involved in DNA replication|DNA replication initiation|MCM complex|identical protein binding|CMG complex|mitotic DNA replication|single-stranded 3'-5' DNA helicase activity" "hsa03030,hsa04110" DNA replication|Cell cycle MCM7 4981.532389 4916.996009 5046.068769 1.026250328 0.037382684 0.876980504 1 89.22510709 90.03504077 4176 minichromosome maintenance complex component 7 "GO:0000082,GO:0000727,GO:0000781,GO:0000785,GO:0003677,GO:0003678,GO:0003688,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006260,GO:0006267,GO:0006268,GO:0006270,GO:0006271,GO:0006974,GO:0008283,GO:0016020,GO:0042325,GO:0042493,GO:0042555,GO:0071162,GO:0071364,GO:0071466,GO:1990518" "G1/S transition of mitotic cell cycle|double-strand break repair via break-induced replication|chromosome, telomeric region|chromatin|DNA binding|DNA helicase activity|DNA replication origin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytosol|DNA replication|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|DNA unwinding involved in DNA replication|DNA replication initiation|DNA strand elongation involved in DNA replication|cellular response to DNA damage stimulus|cell population proliferation|membrane|regulation of phosphorylation|response to drug|MCM complex|CMG complex|cellular response to epidermal growth factor stimulus|cellular response to xenobiotic stimulus|single-stranded 3'-5' DNA helicase activity" "hsa03030,hsa04110" DNA replication|Cell cycle MCM8 1877.03156 1952.856858 1801.206262 0.922344233 -0.116622807 0.623598208 1 9.516973911 8.631039303 84515 minichromosome maintenance 8 homologous recombination repair factor "GO:0000082,GO:0000724,GO:0003678,GO:0003682,GO:0003688,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006260,GO:0006974,GO:0007292,GO:0019899,GO:0032406,GO:0032407,GO:0032408,GO:0032508,GO:0036298,GO:0042555,GO:0048232,GO:0050821,GO:0071168,GO:0097362" G1/S transition of mitotic cell cycle|double-strand break repair via homologous recombination|DNA helicase activity|chromatin binding|DNA replication origin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|chromosome|cytosol|DNA replication|cellular response to DNA damage stimulus|female gamete generation|enzyme binding|MutLbeta complex binding|MutSalpha complex binding|MutSbeta complex binding|DNA duplex unwinding|recombinational interstrand cross-link repair|MCM complex|male gamete generation|protein stabilization|protein localization to chromatin|MCM8-MCM9 complex MCM9 96.07032184 112.3646993 79.77594435 0.709973371 -0.494163181 0.300173093 1 0.614101125 0.428699652 254394 minichromosome maintenance 9 homologous recombination repair factor "GO:0000724,GO:0003678,GO:0003682,GO:0003688,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005694,GO:0006260,GO:0006974,GO:0007292,GO:0019899,GO:0032406,GO:0032407,GO:0032408,GO:0032508,GO:0036298,GO:0042555,GO:0044877,GO:0070716,GO:0071168,GO:0097362" double-strand break repair via homologous recombination|DNA helicase activity|chromatin binding|DNA replication origin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|chromosome|DNA replication|cellular response to DNA damage stimulus|female gamete generation|enzyme binding|MutLbeta complex binding|MutSalpha complex binding|MutSbeta complex binding|DNA duplex unwinding|recombinational interstrand cross-link repair|MCM complex|protein-containing complex binding|mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication|protein localization to chromatin|MCM8-MCM9 complex MCMBP 2154.363453 2155.737565 2152.989341 0.998725159 -0.001840381 0.996036072 1 25.329756 24.87414577 79892 minichromosome maintenance complex binding protein "GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006261,GO:0007062,GO:0030054,GO:0042555,GO:0051301" chromatin binding|protein binding|nucleus|nucleoplasm|cytosol|DNA-dependent DNA replication|sister chromatid cohesion|cell junction|MCM complex|cell division MCMDC2 19.21305828 24.96993318 13.45618338 0.53889545 -0.891922689 0.311343982 1 0.227173447 0.120374158 157777 minichromosome maintenance domain containing 2 "GO:0000727,GO:0003688,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0006267,GO:0006268,GO:0006271,GO:0042555,GO:0051321,GO:1902975" double-strand break repair via break-induced replication|DNA replication origin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|DNA unwinding involved in DNA replication|DNA strand elongation involved in DNA replication|MCM complex|meiotic cell cycle|mitotic DNA replication initiation MCOLN1 213.6031064 233.0527097 194.1535031 0.833088375 -0.263458549 0.461747624 1 5.968135693 4.888785037 57192 mucolipin TRP cation channel 1 "GO:0001891,GO:0002250,GO:0005261,GO:0005381,GO:0005515,GO:0005654,GO:0005764,GO:0005765,GO:0005770,GO:0005794,GO:0005886,GO:0005887,GO:0006812,GO:0008289,GO:0010008,GO:0016020,GO:0016021,GO:0019722,GO:0030670,GO:0031902,GO:0033572,GO:0034755,GO:0042995,GO:0043231,GO:0043235,GO:0051209,GO:0051289,GO:0070588,GO:0071277,GO:0071467,GO:0072345,GO:0090382,GO:0097352,GO:0097682,GO:0099604" "phagocytic cup|adaptive immune response|cation channel activity|iron ion transmembrane transporter activity|protein binding|nucleoplasm|lysosome|lysosomal membrane|late endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|cation transport|lipid binding|endosome membrane|membrane|integral component of membrane|calcium-mediated signaling|phagocytic vesicle membrane|late endosome membrane|transferrin transport|iron ion transmembrane transport|cell projection|intracellular membrane-bounded organelle|receptor complex|release of sequestered calcium ion into cytosol|protein homotetramerization|calcium ion transmembrane transport|cellular response to calcium ion|cellular response to pH|NAADP-sensitive calcium-release channel activity|phagosome maturation|autophagosome maturation|intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity|ligand-gated calcium channel activity" "hsa04020,hsa04142" Calcium signaling pathway|Lysosome MCOLN2 158.5253373 162.3045657 154.7461089 0.953430412 -0.068800451 0.878039418 1 2.310455153 2.165996359 255231 mucolipin TRP cation channel 2 "GO:0002250,GO:0005765,GO:0005886,GO:0015031,GO:0016020,GO:0016021,GO:0031902,GO:0042802,GO:0045087,GO:0051209,GO:0055038,GO:0070588,GO:0071639,GO:0071642,GO:0071651,GO:0072345,GO:1905517,GO:1990266,GO:2000343" adaptive immune response|lysosomal membrane|plasma membrane|protein transport|membrane|integral component of membrane|late endosome membrane|identical protein binding|innate immune response|release of sequestered calcium ion into cytosol|recycling endosome membrane|calcium ion transmembrane transport|positive regulation of monocyte chemotactic protein-1 production|positive regulation of macrophage inflammatory protein 1 alpha production|positive regulation of chemokine (C-C motif) ligand 5 production|NAADP-sensitive calcium-release channel activity|macrophage migration|neutrophil migration|positive regulation of chemokine (C-X-C motif) ligand 2 production hsa04020 Calcium signaling pathway MCOLN3 317.3280774 331.8920286 302.7641261 0.912236812 -0.132519705 0.67503041 1 5.10004825 4.574599278 55283 mucolipin TRP cation channel 3 "GO:0000421,GO:0005765,GO:0005886,GO:0007626,GO:0008289,GO:0016020,GO:0016021,GO:0031901,GO:0031902,GO:0042491,GO:0051209,GO:0070588,GO:0072345" autophagosome membrane|lysosomal membrane|plasma membrane|locomotory behavior|lipid binding|membrane|integral component of membrane|early endosome membrane|late endosome membrane|inner ear auditory receptor cell differentiation|release of sequestered calcium ion into cytosol|calcium ion transmembrane transport|NAADP-sensitive calcium-release channel activity hsa04020 Calcium signaling pathway MCPH1 482.789712 474.4287305 491.1506935 1.035246523 0.049974357 0.863344947 1 1.128164211 1.148384382 79648 microcephalin 1 "GO:0000122,GO:0000132,GO:0000278,GO:0005515,GO:0005654,GO:0005737,GO:0005815,GO:0021987,GO:0042802,GO:0043549,GO:0046605,GO:0050727,GO:0060348,GO:0060623,GO:0071539,GO:0071850,GO:0097150" negative regulation of transcription by RNA polymerase II|establishment of mitotic spindle orientation|mitotic cell cycle|protein binding|nucleoplasm|cytoplasm|microtubule organizing center|cerebral cortex development|identical protein binding|regulation of kinase activity|regulation of centrosome cycle|regulation of inflammatory response|bone development|regulation of chromosome condensation|protein localization to centrosome|mitotic cell cycle arrest|neuronal stem cell population maintenance MCRIP1 328.0247102 322.5283036 333.5211167 1.034083251 0.048352337 0.884444192 1 13.17974179 13.40088822 348262 MAPK regulated corepressor interacting protein 1 "GO:0005515,GO:0005634,GO:0005737,GO:0010494,GO:0010717" protein binding|nucleus|cytoplasm|cytoplasmic stress granule|regulation of epithelial to mesenchymal transition MCRIP2 164.4954483 155.0216685 173.969228 1.122225233 0.166362257 0.681726175 1 8.886381881 9.805645325 84331 MAPK regulated corepressor interacting protein 2 "GO:0005515,GO:0005634,GO:0005737,GO:0010494" protein binding|nucleus|cytoplasm|cytoplasmic stress granule MCRS1 911.2501892 809.4420007 1013.058378 1.251551534 0.323717697 0.191963547 1 20.76847687 25.55786446 10445 microspherule protein 1 "GO:0000123,GO:0002151,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005783,GO:0005844,GO:0006281,GO:0006310,GO:0006464,GO:0008266,GO:0016032,GO:0016579,GO:0030425,GO:0031011,GO:0034046,GO:0043204,GO:0043981,GO:0043982,GO:0043984,GO:0044545,GO:0045944,GO:0071339,GO:1904751" histone acetyltransferase complex|G-quadruplex RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum|polysome|DNA repair|DNA recombination|cellular protein modification process|poly(U) RNA binding|viral process|protein deubiquitination|dendrite|Ino80 complex|poly(G) binding|perikaryon|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|NSL complex|positive regulation of transcription by RNA polymerase II|MLL1 complex|positive regulation of protein localization to nucleolus MCTP1 1031.274568 1008.161052 1054.388084 1.045852824 0.064679845 0.795240942 1 6.806287469 6.999258606 79772 multiple C2 and transmembrane domain containing 1 "GO:0005509,GO:0005544,GO:0005789,GO:0016021,GO:0019722,GO:0030336,GO:0030672,GO:0045806,GO:0046928,GO:0048168,GO:0055037,GO:1902883" calcium ion binding|calcium-dependent phospholipid binding|endoplasmic reticulum membrane|integral component of membrane|calcium-mediated signaling|negative regulation of cell migration|synaptic vesicle membrane|negative regulation of endocytosis|regulation of neurotransmitter secretion|regulation of neuronal synaptic plasticity|recycling endosome|negative regulation of response to oxidative stress MCTS1 2006.847979 1803.037259 2210.658699 1.226074885 0.294047097 0.214047088 1 9.87325925 11.90278847 28985 MCTS1 re-initiation and release factor "GO:0001731,GO:0002188,GO:0003743,GO:0005515,GO:0005829,GO:0005886,GO:0006974,GO:0007049,GO:0008284,GO:0022627,GO:0032790,GO:0040008,GO:0075522" formation of translation preinitiation complex|translation reinitiation|translation initiation factor activity|protein binding|cytosol|plasma membrane|cellular response to DNA damage stimulus|cell cycle|positive regulation of cell population proliferation|cytosolic small ribosomal subunit|ribosome disassembly|regulation of growth|IRES-dependent viral translational initiation MCU 1471.034945 1526.287166 1415.782723 0.92759918 -0.108426551 0.651514673 1 22.55750231 20.57418047 90550 mitochondrial calcium uniporter "GO:0005262,GO:0005515,GO:0005739,GO:0005743,GO:0006851,GO:0015292,GO:0019722,GO:0031305,GO:0032024,GO:0034704,GO:0036444,GO:0042593,GO:0042802,GO:0051259,GO:0051560,GO:0051561,GO:0090023,GO:0090141,GO:0090527,GO:1990246" calcium channel activity|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial calcium ion transmembrane transport|uniporter activity|calcium-mediated signaling|integral component of mitochondrial inner membrane|positive regulation of insulin secretion|calcium channel complex|calcium import into the mitochondrion|glucose homeostasis|identical protein binding|protein complex oligomerization|mitochondrial calcium ion homeostasis|positive regulation of mitochondrial calcium ion concentration|positive regulation of neutrophil chemotaxis|positive regulation of mitochondrial fission|actin filament reorganization|uniplex complex "hsa04020,hsa04218,hsa04621,hsa05010,hsa05012,hsa05014,hsa05017,hsa05020,hsa05022" Calcium signaling pathway|Cellular senescence|NOD-like receptor signaling pathway|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases MCUB 572.6276114 549.33853 595.9166927 1.084789543 0.117415176 0.66244655 1 11.36765712 12.12516435 55013 mitochondrial calcium uniporter dominant negative subunit beta "GO:0005216,GO:0005654,GO:0005739,GO:0005743,GO:0006851,GO:0019855,GO:0031224,GO:0031305,GO:0034704,GO:0036444,GO:0043231,GO:0051560,GO:1990246" ion channel activity|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial calcium ion transmembrane transport|calcium channel inhibitor activity|intrinsic component of membrane|integral component of mitochondrial inner membrane|calcium channel complex|calcium import into the mitochondrion|intracellular membrane-bounded organelle|mitochondrial calcium ion homeostasis|uniplex complex MCUR1 948.0358126 955.0999443 940.9716809 0.985207555 -0.021500404 0.935165296 1 9.311642058 9.020387311 63933 mitochondrial calcium uniporter regulator 1 "GO:0005515,GO:0005739,GO:0006851,GO:0031305,GO:0036444,GO:0051561,GO:0070509" protein binding|mitochondrion|mitochondrial calcium ion transmembrane transport|integral component of mitochondrial inner membrane|calcium import into the mitochondrion|positive regulation of mitochondrial calcium ion concentration|calcium ion import MDC1 1187.622885 1504.438474 870.8072961 0.578825463 -0.788799707 0.001180212 0.212360525 9.855052944 5.608900916 9656 mediator of DNA damage checkpoint 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005925,GO:0006303,GO:0008022,GO:0016604,GO:0031573,GO:0042802,GO:0070975" protein binding|nucleus|nucleoplasm|chromosome|focal adhesion|double-strand break repair via nonhomologous end joining|protein C-terminus binding|nuclear body|intra-S DNA damage checkpoint|identical protein binding|FHA domain binding MDFI 5.003924597 5.202069413 4.80577978 0.923820772 -0.11431511 1 1 0.090697446 0.082386103 4188 MyoD family inhibitor "GO:0000122,GO:0005515,GO:0005634,GO:0005737,GO:0008134,GO:0009950,GO:0030178,GO:0042802,GO:0042994,GO:0043392,GO:0048704,GO:0060707,GO:0140416" negative regulation of transcription by RNA polymerase II|protein binding|nucleus|cytoplasm|transcription factor binding|dorsal/ventral axis specification|negative regulation of Wnt signaling pathway|identical protein binding|cytoplasmic sequestering of transcription factor|negative regulation of DNA binding|embryonic skeletal system morphogenesis|trophoblast giant cell differentiation|transcription regulator inhibitor activity MDFIC 867.7006467 852.0989699 883.3023236 1.036619401 0.0518863 0.839371353 1 8.238216654 8.39699163 29969 MyoD family inhibitor domain containing "GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0007257,GO:0008134,GO:0016032,GO:0030111,GO:0030332,GO:0030957,GO:0042308,GO:0045892,GO:0045893,GO:0050434" "protein binding|nucleus|nucleolus|cytoplasm|activation of JUN kinase activity|transcription factor binding|viral process|regulation of Wnt signaling pathway|cyclin binding|Tat protein binding|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of viral transcription" MDGA1 19.37660456 16.64662212 22.10658699 1.327992359 0.409246846 0.674434087 1 0.085267264 0.111339453 266727 MAM domain containing glycosylphosphatidylinositol anchor 1 "GO:0001764,GO:0003674,GO:0005576,GO:0005615,GO:0005794,GO:0005886,GO:0007420,GO:0021527,GO:0046658,GO:0098982,GO:0099179,GO:1905606" neuron migration|molecular_function|extracellular region|extracellular space|Golgi apparatus|plasma membrane|brain development|spinal cord association neuron differentiation|anchored component of plasma membrane|GABA-ergic synapse|regulation of synaptic membrane adhesion|regulation of presynapse assembly MDH1 3099.905099 2641.610848 3558.199349 1.346980897 0.42972939 0.069819907 1 91.84229048 121.6396946 4190 malate dehydrogenase 1 "GO:0004470,GO:0005515,GO:0005615,GO:0005813,GO:0005829,GO:0006094,GO:0006099,GO:0006107,GO:0006108,GO:0006734,GO:0030060,GO:0047860,GO:0070062" malic enzyme activity|protein binding|extracellular space|centrosome|cytosol|gluconeogenesis|tricarboxylic acid cycle|oxaloacetate metabolic process|malate metabolic process|NADH metabolic process|L-malate dehydrogenase activity|diiodophenylpyruvate reductase activity|extracellular exosome "hsa00020,hsa00270,hsa00620,hsa00630,hsa04964" Citrate cycle (TCA cycle)|Cysteine and methionine metabolism|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Proximal tubule bicarbonate reclamation MDH1B 11.127521 14.56579436 7.689247648 0.527897584 -0.921670032 0.421966432 1 0.304843009 0.158233011 130752 malate dehydrogenase 1B "GO:0005975,GO:0006099,GO:0006107,GO:0006108,GO:0006734,GO:0030060" carbohydrate metabolic process|tricarboxylic acid cycle|oxaloacetate metabolic process|malate metabolic process|NADH metabolic process|L-malate dehydrogenase activity MDH2 3883.330992 3527.003062 4239.658922 1.202057057 0.265505377 0.264583371 1 86.7417839 102.5237801 4191 malate dehydrogenase 2 "GO:0003723,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0006094,GO:0006099,GO:0006107,GO:0006108,GO:0006734,GO:0009060,GO:0016020,GO:0030060,GO:0043621,GO:0046554,GO:0070062" RNA binding|nucleus|cytoplasm|mitochondrion|mitochondrial matrix|gluconeogenesis|tricarboxylic acid cycle|oxaloacetate metabolic process|malate metabolic process|NADH metabolic process|aerobic respiration|membrane|L-malate dehydrogenase activity|protein self-association|malate dehydrogenase (NADP+) activity|extracellular exosome "hsa00020,hsa00270,hsa00620,hsa00630" Citrate cycle (TCA cycle)|Cysteine and methionine metabolism|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism MDK 3192.969994 3255.455039 3130.484949 0.961612098 -0.056473049 0.812670422 1 107.9115852 102.0326507 4192 midkine "GO:0002232,GO:0002286,GO:0002690,GO:0005515,GO:0005576,GO:0007010,GO:0007162,GO:0007165,GO:0007219,GO:0007399,GO:0008083,GO:0008201,GO:0009611,GO:0010667,GO:0010718,GO:0010759,GO:0010838,GO:0010976,GO:0010996,GO:0030154,GO:0030279,GO:0030325,GO:0030335,GO:0032330,GO:0032735,GO:0035374,GO:0042246,GO:0043524,GO:0044849,GO:0045582,GO:0045590,GO:0045785,GO:0046850,GO:0048477,GO:0048714,GO:0050729,GO:0051781,GO:0061036,GO:0062023,GO:0071673,GO:0090023,GO:0090090,GO:0106015,GO:0106016,GO:0106091,GO:1900026,GO:1903039,GO:1904036,GO:1904399,GO:1904996,GO:1905555,GO:1905564,GO:1905653,GO:2000179,GO:2000249,GO:2000347,GO:2000391,GO:2001224" leukocyte chemotaxis involved in inflammatory response|T cell activation involved in immune response|positive regulation of leukocyte chemotaxis|protein binding|extracellular region|cytoskeleton organization|negative regulation of cell adhesion|signal transduction|Notch signaling pathway|nervous system development|growth factor activity|heparin binding|response to wounding|negative regulation of cardiac muscle cell apoptotic process|positive regulation of epithelial to mesenchymal transition|positive regulation of macrophage chemotaxis|positive regulation of keratinocyte proliferation|positive regulation of neuron projection development|response to auditory stimulus|cell differentiation|negative regulation of ossification|adrenal gland development|positive regulation of cell migration|regulation of chondrocyte differentiation|positive regulation of interleukin-12 production|chondroitin sulfate binding|tissue regeneration|negative regulation of neuron apoptotic process|estrous cycle|positive regulation of T cell differentiation|negative regulation of regulatory T cell differentiation|positive regulation of cell adhesion|regulation of bone remodeling|oogenesis|positive regulation of oligodendrocyte differentiation|positive regulation of inflammatory response|positive regulation of cell division|positive regulation of cartilage development|collagen-containing extracellular matrix|positive regulation of smooth muscle cell chemotaxis|positive regulation of neutrophil chemotaxis|negative regulation of canonical Wnt signaling pathway|negative regulation of inflammatory response to wounding|positive regulation of inflammatory response to wounding|glial cell projection elongation|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of leukocyte cell-cell adhesion|negative regulation of epithelial cell apoptotic process|heparan sulfate binding|positive regulation of leukocyte adhesion to vascular endothelial cell|positive regulation of blood vessel branching|positive regulation of vascular endothelial cell proliferation|positive regulation of artery morphogenesis|positive regulation of neural precursor cell proliferation|regulation of actin cytoskeleton reorganization|positive regulation of hepatocyte proliferation|positive regulation of neutrophil extravasation|positive regulation of neuron migration MDM1 311.1598216 333.9728563 288.3467868 0.863383899 -0.211925907 0.499719215 1 2.571565074 2.183095038 56890 Mdm1 nuclear protein "GO:0005515,GO:0005634,GO:0005813,GO:0005814,GO:0005829,GO:0005874,GO:0008017,GO:0045494,GO:0046600,GO:0060041" protein binding|nucleus|centrosome|centriole|cytosol|microtubule|microtubule binding|photoreceptor cell maintenance|negative regulation of centriole replication|retina development in camera-type eye MDM2 1856.089918 1844.653814 1867.526022 1.012399188 0.017778255 0.942607305 1 13.06166694 13.00234161 4193 MDM2 proto-oncogene "GO:0000122,GO:0000209,GO:0001228,GO:0002039,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006357,GO:0006511,GO:0006915,GO:0006977,GO:0008097,GO:0008270,GO:0008284,GO:0016032,GO:0016567,GO:0016579,GO:0016604,GO:0016874,GO:0016925,GO:0018215,GO:0019789,GO:0019899,GO:0019904,GO:0030666,GO:0031625,GO:0031648,GO:0032436,GO:0032991,GO:0034504,GO:0036369,GO:0042176,GO:0042802,GO:0043021,GO:0043130,GO:0043161,GO:0043518,GO:0045184,GO:0045892,GO:0045931,GO:0045944,GO:0046677,GO:0047485,GO:0051603,GO:0051865,GO:0061630,GO:0061663,GO:0065003,GO:0071157,GO:0071456,GO:0071480,GO:0072717,GO:0097718,GO:1901796,GO:1901797,GO:1902254,GO:1990000" "negative regulation of transcription by RNA polymerase II|protein polyubiquitination|DNA-binding transcription activator activity, RNA polymerase II-specific|p53 binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|ubiquitin-dependent protein catabolic process|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|5S rRNA binding|zinc ion binding|positive regulation of cell population proliferation|viral process|protein ubiquitination|protein deubiquitination|nuclear body|ligase activity|protein sumoylation|protein phosphopantetheinylation|SUMO transferase activity|enzyme binding|protein domain specific binding|endocytic vesicle membrane|ubiquitin protein ligase binding|protein destabilization|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein-containing complex|protein localization to nucleus|transcription factor catabolic process|regulation of protein catabolic process|identical protein binding|ribonucleoprotein complex binding|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of DNA damage response, signal transduction by p53 class mediator|establishment of protein localization|negative regulation of transcription, DNA-templated|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|response to antibiotic|protein N-terminus binding|proteolysis involved in cellular protein catabolic process|protein autoubiquitination|ubiquitin protein ligase activity|NEDD8 ligase activity|protein-containing complex assembly|negative regulation of cell cycle arrest|cellular response to hypoxia|cellular response to gamma radiation|cellular response to actinomycin D|disordered domain specific binding|regulation of signal transduction by p53 class mediator|negative regulation of signal transduction by p53 class mediator|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|amyloid fibril formation" "hsa01522,hsa01524,hsa04068,hsa04110,hsa04115,hsa04120,hsa04144,hsa04151,hsa04218,hsa04625,hsa04919,hsa05131,hsa05163,hsa05165,hsa05169,hsa05200,hsa05202,hsa05203,hsa05205,hsa05206,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220" Endocrine resistance|Platinum drug resistance|FoxO signaling pathway|Cell cycle|p53 signaling pathway|Ubiquitin mediated proteolysis|Endocytosis|PI3K-Akt signaling pathway|Cellular senescence|C-type lectin receptor signaling pathway|Thyroid hormone signaling pathway|Shigellosis|Human cytomegalovirus infection|Human papillomavirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia MDM4 548.9453123 583.6721882 514.2184365 0.881005549 -0.182776989 0.497290818 1 2.968599251 2.571588031 4194 MDM4 regulator of p53 "GO:0000122,GO:0001228,GO:0003170,GO:0003181,GO:0003203,GO:0003281,GO:0003283,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006977,GO:0008270,GO:0008285,GO:0016579,GO:0019899,GO:0030330,GO:0042177,GO:0043066,GO:0045944,GO:0050821,GO:0065003,GO:0071157,GO:0071456,GO:1901796" "negative regulation of transcription by RNA polymerase II|DNA-binding transcription activator activity, RNA polymerase II-specific|heart valve development|atrioventricular valve morphogenesis|endocardial cushion morphogenesis|ventricular septum development|atrial septum development|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|zinc ion binding|negative regulation of cell population proliferation|protein deubiquitination|enzyme binding|DNA damage response, signal transduction by p53 class mediator|negative regulation of protein catabolic process|negative regulation of apoptotic process|positive regulation of transcription by RNA polymerase II|protein stabilization|protein-containing complex assembly|negative regulation of cell cycle arrest|cellular response to hypoxia|regulation of signal transduction by p53 class mediator" "hsa04115,hsa05206" p53 signaling pathway|MicroRNAs in cancer MDN1 1136.806766 1293.234456 980.3790751 0.758083015 -0.399572254 0.100264118 1 3.359662467 2.504284078 23195 midasin AAA ATPase 1 "GO:0000027,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006364,GO:0016020,GO:0016887,GO:0030687,GO:0045111,GO:0051082,GO:0065003" "ribosomal large subunit assembly|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytosol|rRNA processing|membrane|ATPase activity|preribosome, large subunit precursor|intermediate filament cytoskeleton|unfolded protein binding|protein-containing complex assembly" hsa03008 Ribosome biogenesis in eukaryotes MDP1 11.00863411 11.44455271 10.57271552 0.923820772 -0.11431511 1 1 0.792185141 0.719590786 145553 magnesium dependent phosphatase 1 "GO:0003993,GO:0004725,GO:0030389,GO:0035335,GO:0046872" acid phosphatase activity|protein tyrosine phosphatase activity|fructosamine metabolic process|peptidyl-tyrosine dephosphorylation|metal ion binding ME1 593.0741979 594.076327 592.0720689 0.996626262 -0.004875505 0.992542605 1 9.421920269 9.233002013 4199 malic enzyme 1 "GO:0004470,GO:0004471,GO:0004473,GO:0005739,GO:0005829,GO:0005975,GO:0006090,GO:0006108,GO:0008948,GO:0009055,GO:0009165,GO:0009725,GO:0009743,GO:0019216,GO:0022900,GO:0030145,GO:0042802,GO:0043531,GO:0050661,GO:0051287,GO:1902031" malic enzyme activity|malate dehydrogenase (decarboxylating) (NAD+) activity|malate dehydrogenase (decarboxylating) (NADP+) activity|mitochondrion|cytosol|carbohydrate metabolic process|pyruvate metabolic process|malate metabolic process|oxaloacetate decarboxylase activity|electron transfer activity|nucleotide biosynthetic process|response to hormone|response to carbohydrate|regulation of lipid metabolic process|electron transport chain|manganese ion binding|identical protein binding|ADP binding|NADP binding|NAD binding|regulation of NADP metabolic process "hsa00620,hsa03320" Pyruvate metabolism|PPAR signaling pathway ME2 1412.959851 1439.932814 1385.986889 0.962535804 -0.055087888 0.82055376 1 8.509198071 8.053352424 4200 malic enzyme 2 "GO:0004470,GO:0004471,GO:0004473,GO:0005739,GO:0005759,GO:0006090,GO:0006099,GO:0006108,GO:0008948,GO:0009055,GO:0022900,GO:0043231,GO:0046872,GO:0051287,GO:1902031" malic enzyme activity|malate dehydrogenase (decarboxylating) (NAD+) activity|malate dehydrogenase (decarboxylating) (NADP+) activity|mitochondrion|mitochondrial matrix|pyruvate metabolic process|tricarboxylic acid cycle|malate metabolic process|oxaloacetate decarboxylase activity|electron transfer activity|electron transport chain|intracellular membrane-bounded organelle|metal ion binding|NAD binding|regulation of NADP metabolic process hsa00620 Pyruvate metabolism ME3 164.8420481 189.3553266 140.3287696 0.741086993 -0.432285191 0.270712861 1 3.824960546 2.787194839 10873 malic enzyme 3 "GO:0004470,GO:0004471,GO:0004473,GO:0005739,GO:0005759,GO:0006090,GO:0006099,GO:0006108,GO:0008948,GO:0009060,GO:0046872,GO:0051287,GO:0055114,GO:0070401,GO:0072592" malic enzyme activity|malate dehydrogenase (decarboxylating) (NAD+) activity|malate dehydrogenase (decarboxylating) (NADP+) activity|mitochondrion|mitochondrial matrix|pyruvate metabolic process|tricarboxylic acid cycle|malate metabolic process|oxaloacetate decarboxylase activity|aerobic respiration|metal ion binding|NAD binding|oxidation-reduction process|NADP+ binding|oxygen metabolic process "hsa00620,hsa03320" Pyruvate metabolism|PPAR signaling pathway MEA1 997.6693225 920.7662861 1074.572359 1.167041382 0.222855718 0.365506162 1 14.28476872 16.39195102 4201 male-enhanced antigen 1 "GO:0005515,GO:0007283,GO:0008584,GO:0030154" protein binding|spermatogenesis|male gonad development|cell differentiation MEAF6 1176.924294 1021.686433 1332.162155 1.303885529 0.382817218 0.114462922 1 11.5227234 14.77290078 64769 MYST/Esa1 associated factor 6 "GO:0000776,GO:0000777,GO:0005515,GO:0005654,GO:0005730,GO:0035267,GO:0043968,GO:0043972,GO:0043981,GO:0043982,GO:0043983,GO:0043984,GO:0043994,GO:0044154,GO:0070776,GO:1901796,GO:1990467,GO:1990468" kinetochore|condensed chromosome kinetochore|protein binding|nucleoplasm|nucleolus|NuA4 histone acetyltransferase complex|histone H2A acetylation|histone H3-K23 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K12 acetylation|histone H4-K16 acetylation|histone acetyltransferase activity (H3-K23 specific)|histone H3-K14 acetylation|MOZ/MORF histone acetyltransferase complex|regulation of signal transduction by p53 class mediator|NuA3a histone acetyltransferase complex|NuA3b histone acetyltransferase complex MEAK7 2064.174538 1958.058927 2170.290149 1.108388577 0.148463748 0.530951069 1 18.15146885 19.78221852 57707 "MTOR associated protein, eak-7 homolog" "GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005765,GO:0005829,GO:0016020,GO:0030334,GO:0031667,GO:0031929,GO:0032868,GO:0042127,GO:0043200,GO:0150032,GO:1903204" protein binding|nucleoplasm|nucleolus|cytoplasm|lysosomal membrane|cytosol|membrane|regulation of cell migration|response to nutrient levels|TOR signaling|response to insulin|regulation of cell population proliferation|response to amino acid|positive regulation of protein localization to lysosome|negative regulation of oxidative stress-induced neuron death MECOM 556.6194687 621.1270879 492.1118495 0.792288501 -0.335902231 0.208331366 1 4.610990555 3.592102858 2122 MDS1 and EVI1 complex locus "GO:0000118,GO:0000978,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006915,GO:0016607,GO:0030154,GO:0043069,GO:0045892,GO:0045893,GO:0045944,GO:0046329,GO:0046872,GO:0046974,GO:0051567,GO:0051726,GO:0070828,GO:0071425" "histone deacetylase complex|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|apoptotic process|nuclear speck|cell differentiation|negative regulation of programmed cell death|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of JNK cascade|metal ion binding|histone methyltransferase activity (H3-K9 specific)|histone H3-K9 methylation|regulation of cell cycle|heterochromatin organization|hematopoietic stem cell proliferation" "hsa00310,hsa04010,hsa05200,hsa05220" Lysine degradation|MAPK signaling pathway|Pathways in cancer|Chronic myeloid leukemia zf-C2H2 MECP2 3104.250537 3386.547188 2821.953887 0.833283498 -0.263120685 0.266626653 1 15.84411319 12.9817098 4204 methyl-CpG binding protein 2 "GO:0000122,GO:0000792,GO:0001662,GO:0001666,GO:0001964,GO:0001976,GO:0002087,GO:0003677,GO:0003682,GO:0003700,GO:0003714,GO:0003723,GO:0003729,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0006020,GO:0006342,GO:0006349,GO:0006367,GO:0006541,GO:0006576,GO:0007052,GO:0007416,GO:0007585,GO:0007616,GO:0008104,GO:0008134,GO:0008211,GO:0008284,GO:0008327,GO:0008344,GO:0008542,GO:0009791,GO:0010385,GO:0010629,GO:0010971,GO:0016358,GO:0016525,GO:0016571,GO:0016573,GO:0019230,GO:0019233,GO:0019904,GO:0021549,GO:0021591,GO:0032048,GO:0035176,GO:0035197,GO:0042551,GO:0043524,GO:0043537,GO:0045892,GO:0045944,GO:0046470,GO:0047485,GO:0051151,GO:0051707,GO:0060079,GO:0060291,GO:0090063,GO:0098794,GO:1900114,GO:1905643,GO:1990841,GO:2000820" "negative regulation of transcription by RNA polymerase II|heterochromatin|behavioral fear response|response to hypoxia|startle response|nervous system process involved in regulation of systemic arterial blood pressure|regulation of respiratory gaseous exchange by nervous system process|DNA binding|chromatin binding|DNA-binding transcription factor activity|transcription corepressor activity|RNA binding|mRNA binding|protein binding|extracellular space|nucleus|nucleoplasm|centrosome|cytosol|inositol metabolic process|chromatin silencing|regulation of gene expression by genetic imprinting|transcription initiation from RNA polymerase II promoter|glutamine metabolic process|cellular biogenic amine metabolic process|mitotic spindle organization|synapse assembly|respiratory gaseous exchange by respiratory system|long-term memory|protein localization|transcription factor binding|glucocorticoid metabolic process|positive regulation of cell population proliferation|methyl-CpG binding|adult locomotory behavior|visual learning|post-embryonic development|double-stranded methylated DNA binding|negative regulation of gene expression|positive regulation of G2/M transition of mitotic cell cycle|dendrite development|negative regulation of angiogenesis|histone methylation|histone acetylation|proprioception|sensory perception of pain|protein domain specific binding|cerebellum development|ventricular system development|cardiolipin metabolic process|social behavior|siRNA binding|neuron maturation|negative regulation of neuron apoptotic process|negative regulation of blood vessel endothelial cell migration|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|phosphatidylcholine metabolic process|protein N-terminus binding|negative regulation of smooth muscle cell differentiation|response to other organism|excitatory postsynaptic potential|long-term synaptic potentiation|positive regulation of microtubule nucleation|postsynapse|positive regulation of histone H3-K9 trimethylation|positive regulation of DNA methylation|promoter-specific chromatin binding|negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" MBD MECR 295.3950975 298.5987843 292.1914106 0.978541863 -0.031294523 0.932489964 1 5.177280155 4.981409616 51102 mitochondrial trans-2-enoyl-CoA reductase "GO:0005634,GO:0005739,GO:0005759,GO:0006631,GO:0006633,GO:0006635,GO:0019166" nucleus|mitochondrion|mitochondrial matrix|fatty acid metabolic process|fatty acid biosynthetic process|fatty acid beta-oxidation|trans-2-enoyl-CoA reductase (NADPH) activity "hsa00061,hsa00062" Fatty acid biosynthesis|Fatty acid elongation MED1 2035.049938 2379.42655 1690.673327 0.710538145 -0.493015993 0.037295057 0.976326461 15.60595081 10.90307024 5469 mediator complex subunit 1 "GO:0000122,GO:0000151,GO:0000785,GO:0000902,GO:0000978,GO:0001525,GO:0001889,GO:0001892,GO:0002088,GO:0002154,GO:0003222,GO:0003406,GO:0003682,GO:0003712,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0006367,GO:0006590,GO:0006606,GO:0006702,GO:0007420,GO:0007595,GO:0008134,GO:0010628,GO:0010839,GO:0016020,GO:0016567,GO:0016592,GO:0016922,GO:0019216,GO:0030216,GO:0030224,GO:0030331,GO:0030374,GO:0030518,GO:0031100,GO:0031490,GO:0032993,GO:0033148,GO:0035050,GO:0035116,GO:0035162,GO:0035257,GO:0035357,GO:0035729,GO:0035855,GO:0042789,GO:0042809,GO:0042974,GO:0042975,GO:0043066,GO:0044877,GO:0045444,GO:0045618,GO:0045648,GO:0045665,GO:0045893,GO:0045944,GO:0046966,GO:0048821,GO:0048822,GO:0050693,GO:0060261,GO:0060335,GO:0060744,GO:0060745,GO:0060750,GO:0061630,GO:0070318,GO:0070562,GO:0071364,GO:0071383,GO:0097067,GO:1990841,GO:2000347,GO:2001141" "negative regulation of transcription by RNA polymerase II|ubiquitin ligase complex|chromatin|cell morphogenesis|RNA polymerase II cis-regulatory region sequence-specific DNA binding|angiogenesis|liver development|embryonic placenta development|lens development in camera-type eye|thyroid hormone mediated signaling pathway|ventricular trabecula myocardium morphogenesis|retinal pigment epithelium development|chromatin binding|transcription coregulator activity|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|thyroid hormone generation|protein import into nucleus|androgen biosynthetic process|brain development|lactation|transcription factor binding|positive regulation of gene expression|negative regulation of keratinocyte proliferation|membrane|protein ubiquitination|mediator complex|nuclear receptor binding|regulation of lipid metabolic process|keratinocyte differentiation|monocyte differentiation|estrogen receptor binding|nuclear receptor coactivator activity|intracellular steroid hormone receptor signaling pathway|animal organ regeneration|chromatin DNA binding|protein-DNA complex|positive regulation of intracellular estrogen receptor signaling pathway|embryonic heart tube development|embryonic hindlimb morphogenesis|embryonic hemopoiesis|nuclear hormone receptor binding|peroxisome proliferator activated receptor signaling pathway|cellular response to hepatocyte growth factor stimulus|megakaryocyte development|mRNA transcription by RNA polymerase II|vitamin D receptor binding|retinoic acid receptor binding|peroxisome proliferator activated receptor binding|negative regulation of apoptotic process|protein-containing complex binding|fat cell differentiation|positive regulation of keratinocyte differentiation|positive regulation of erythrocyte differentiation|negative regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|thyroid hormone receptor binding|erythrocyte development|enucleate erythrocyte development|LBD domain binding|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of interferon-gamma-mediated signaling pathway|mammary gland branching involved in thelarche|mammary gland branching involved in pregnancy|epithelial cell proliferation involved in mammary gland duct elongation|ubiquitin protein ligase activity|positive regulation of G0 to G1 transition|regulation of vitamin D receptor signaling pathway|cellular response to epidermal growth factor stimulus|cellular response to steroid hormone stimulus|cellular response to thyroid hormone stimulus|promoter-specific chromatin binding|positive regulation of hepatocyte proliferation|regulation of RNA biosynthetic process" "hsa01522,hsa04919" Endocrine resistance|Thyroid hormone signaling pathway other MED10 800.0737443 716.8451651 883.3023236 1.232207967 0.301245769 0.231538267 1 34.74723793 42.09935858 84246 mediator complex subunit 10 "GO:0000151,GO:0003712,GO:0005515,GO:0005654,GO:0006367,GO:0016567,GO:0016592,GO:0045944,GO:0061630" ubiquitin ligase complex|transcription coregulator activity|protein binding|nucleoplasm|transcription initiation from RNA polymerase II promoter|protein ubiquitination|mediator complex|positive regulation of transcription by RNA polymerase II|ubiquitin protein ligase activity MED11 131.390288 118.6071826 144.1733934 1.215553647 0.281613566 0.515727087 1 6.684104906 7.988929096 400569 mediator complex subunit 11 "GO:0000151,GO:0003712,GO:0005515,GO:0006357,GO:0016567,GO:0016592,GO:0061630" ubiquitin ligase complex|transcription coregulator activity|protein binding|regulation of transcription by RNA polymerase II|protein ubiquitination|mediator complex|ubiquitin protein ligase activity MED12 877.7273888 1014.403536 741.0512421 0.730529041 -0.452986469 0.068774416 1 7.817596 5.615415378 9968 mediator complex subunit 12 "GO:0000151,GO:0000978,GO:0001843,GO:0003682,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006367,GO:0007492,GO:0007507,GO:0008013,GO:0008022,GO:0014003,GO:0014044,GO:0016020,GO:0016567,GO:0016592,GO:0019827,GO:0019904,GO:0021510,GO:0030374,GO:0036342,GO:0042809,GO:0045893,GO:0045944,GO:0046966,GO:0048702,GO:0060070,GO:0060071,GO:0060261,GO:0061630,GO:0090245,GO:1990403" "ubiquitin ligase complex|RNA polymerase II cis-regulatory region sequence-specific DNA binding|neural tube closure|chromatin binding|transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|endoderm development|heart development|beta-catenin binding|protein C-terminus binding|oligodendrocyte development|Schwann cell development|membrane|protein ubiquitination|mediator complex|stem cell population maintenance|protein domain specific binding|spinal cord development|nuclear receptor coactivator activity|post-anal tail morphogenesis|vitamin D receptor binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|thyroid hormone receptor binding|embryonic neurocranium morphogenesis|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|positive regulation of transcription initiation from RNA polymerase II promoter|ubiquitin protein ligase activity|axis elongation involved in somitogenesis|embryonic brain development" hsa04919 Thyroid hormone signaling pathway other MED12L 46.07070483 61.38441908 30.75699059 0.501055334 -0.996958159 0.106898005 1 0.353166626 0.173994902 116931 mediator complex subunit 12L "GO:0003713,GO:0005515,GO:0006357,GO:0008013,GO:0008134,GO:0016592,GO:0045893" "transcription coactivator activity|protein binding|regulation of transcription by RNA polymerase II|beta-catenin binding|transcription factor binding|mediator complex|positive regulation of transcription, DNA-templated" hsa04919 Thyroid hormone signaling pathway MED13 2640.604072 3010.957776 2270.250368 0.753996083 -0.407371067 0.085024766 1 14.35751274 10.64435814 9969 mediator complex subunit 13 "GO:0003712,GO:0003713,GO:0005634,GO:0005654,GO:0006357,GO:0006367,GO:0016020,GO:0016592,GO:0030374,GO:0042809,GO:0045893,GO:0045944,GO:0046966,GO:0060261" "transcription coregulator activity|transcription coactivator activity|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|membrane|mediator complex|nuclear receptor coactivator activity|vitamin D receptor binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|thyroid hormone receptor binding|positive regulation of transcription initiation from RNA polymerase II promoter" hsa04919 Thyroid hormone signaling pathway MED13L 1787.94158 1910.199889 1665.683272 0.871994225 -0.197609514 0.405056241 1 10.42690572 8.940055897 23389 mediator complex subunit 13L "GO:0003712,GO:0006357,GO:0016592" transcription coregulator activity|regulation of transcription by RNA polymerase II|mediator complex hsa04919 Thyroid hormone signaling pathway MED14 2883.167618 2931.886321 2834.448914 0.966766308 -0.048760899 0.837985147 1 18.89726865 17.96353161 9282 mediator complex subunit 14 "GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006367,GO:0016020,GO:0016592,GO:0019827,GO:0030374,GO:0042809,GO:0045893,GO:0045944,GO:0060261,GO:0070847" "transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|membrane|mediator complex|stem cell population maintenance|nuclear receptor coactivator activity|vitamin D receptor binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of transcription initiation from RNA polymerase II promoter|core mediator complex" hsa04919 Thyroid hormone signaling pathway MED15 2040.343784 1963.260997 2117.426571 1.078525257 0.109059962 0.64591404 1 18.72330791 19.85564859 51586 mediator complex subunit 15 "GO:0003712,GO:0005515,GO:0005654,GO:0005737,GO:0006357,GO:0006367,GO:0016020,GO:0016592" transcription coregulator activity|protein binding|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|membrane|mediator complex MED16 407.770472 397.4381032 418.1028409 1.051994858 0.073127653 0.806862737 1 7.329143437 7.581201098 10025 mediator complex subunit 16 "GO:0003713,GO:0003824,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006366,GO:0006367,GO:0016020,GO:0016592,GO:0042809,GO:0045893,GO:0046966,GO:0060261" "transcription coactivator activity|catalytic activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|membrane|mediator complex|vitamin D receptor binding|positive regulation of transcription, DNA-templated|thyroid hormone receptor binding|positive regulation of transcription initiation from RNA polymerase II promoter" hsa04919 Thyroid hormone signaling pathway MED17 851.1383129 808.4015868 893.8750391 1.105731426 0.145001008 0.563881968 1 8.481011777 9.220797778 9440 mediator complex subunit 17 "GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0016020,GO:0016592,GO:0030374,GO:0042809,GO:0045893,GO:0045944,GO:0046966,GO:0060261,GO:0070847" "transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|membrane|mediator complex|nuclear receptor coactivator activity|vitamin D receptor binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|thyroid hormone receptor binding|positive regulation of transcription initiation from RNA polymerase II promoter|core mediator complex" hsa04919 Thyroid hormone signaling pathway MED18 291.6297316 300.6796121 282.5798511 0.93980383 -0.089568448 0.786893557 1 8.590320274 7.93812156 54797 mediator complex subunit 18 "GO:0000151,GO:0003712,GO:0005515,GO:0006357,GO:0006369,GO:0016567,GO:0016592,GO:0061630,GO:0070847" ubiquitin ligase complex|transcription coregulator activity|protein binding|regulation of transcription by RNA polymerase II|termination of RNA polymerase II transcription|protein ubiquitination|mediator complex|ubiquitin protein ligase activity|core mediator complex MED19 300.9091682 329.8112008 272.0071355 0.824735894 -0.277995897 0.378691434 1 11.48168142 9.310897964 219541 mediator complex subunit 19 "GO:0003712,GO:0005515,GO:0008134,GO:0016592,GO:0045944" transcription coregulator activity|protein binding|transcription factor binding|mediator complex|positive regulation of transcription by RNA polymerase II MED20 409.1524553 446.3375557 371.967355 0.83337678 -0.262959191 0.361823081 1 8.699859391 7.128937511 9477 mediator complex subunit 20 "GO:0000151,GO:0003713,GO:0003899,GO:0005515,GO:0005654,GO:0006351,GO:0006357,GO:0006366,GO:0006367,GO:0016567,GO:0016592,GO:0045893,GO:0061630" "ubiquitin ligase complex|transcription coactivator activity|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|protein ubiquitination|mediator complex|positive regulation of transcription, DNA-templated|ubiquitin protein ligase activity" MED21 877.3021454 877.0689031 877.5353878 1.000531868 0.000767119 1 1 17.53748796 17.25319339 9412 mediator complex subunit 21 "GO:0003712,GO:0003713,GO:0003899,GO:0005515,GO:0006357,GO:0016592,GO:0032774,GO:0045944" transcription coregulator activity|transcription coactivator activity|DNA-directed 5'-3' RNA polymerase activity|protein binding|regulation of transcription by RNA polymerase II|mediator complex|RNA biosynthetic process|positive regulation of transcription by RNA polymerase II MED22 1116.945167 1188.152654 1045.73768 0.880137478 -0.184199204 0.450367783 1 9.794489251 8.476244722 6837 mediator complex subunit 22 "GO:0003712,GO:0005515,GO:0005737,GO:0006357,GO:0016592" transcription coregulator activity|protein binding|cytoplasm|regulation of transcription by RNA polymerase II|mediator complex MED23 681.7873951 677.3094376 686.2653526 1.013222782 0.018951421 0.947451982 1 6.338200919 6.314545935 9439 mediator complex subunit 23 "GO:0003713,GO:0005515,GO:0005654,GO:0005667,GO:0006355,GO:0006357,GO:0006367,GO:0010628,GO:0016592,GO:0045893" "transcription coactivator activity|protein binding|nucleoplasm|transcription regulator complex|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|positive regulation of gene expression|mediator complex|positive regulation of transcription, DNA-templated" MED24 2596.601561 2587.509326 2605.693797 1.007027789 0.010103496 0.967708929 1 38.80039817 38.41924413 9862 mediator complex subunit 24 "GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006367,GO:0016592,GO:0030374,GO:0042809,GO:0045893,GO:0046966,GO:0060261" "transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|mediator complex|nuclear receptor coactivator activity|vitamin D receptor binding|positive regulation of transcription, DNA-templated|thyroid hormone receptor binding|positive regulation of transcription initiation from RNA polymerase II promoter" hsa04919 Thyroid hormone signaling pathway MED25 950.9790311 906.2004918 995.7575704 1.098827003 0.135964269 0.584113049 1 11.69017518 12.63052844 81857 mediator complex subunit 25 "GO:0000122,GO:0001223,GO:0005515,GO:0005654,GO:0005667,GO:0006367,GO:0008134,GO:0016592,GO:0035563,GO:0042974,GO:0045944,GO:0046965,GO:0048147,GO:0071158,GO:2001178" negative regulation of transcription by RNA polymerase II|transcription coactivator binding|protein binding|nucleoplasm|transcription regulator complex|transcription initiation from RNA polymerase II promoter|transcription factor binding|mediator complex|positive regulation of chromatin binding|retinoic acid receptor binding|positive regulation of transcription by RNA polymerase II|retinoid X receptor binding|negative regulation of fibroblast proliferation|positive regulation of cell cycle arrest|positive regulation of mediator complex assembly MED26 135.8293463 134.2133909 137.4453017 1.02408039 0.034328971 0.954101523 1 2.258109078 2.273788918 9441 mediator complex subunit 26 "GO:0003712,GO:0003713,GO:0005515,GO:0005654,GO:0006357,GO:0006367,GO:0010628,GO:0016592,GO:0045893,GO:0070847" "transcription coregulator activity|transcription coactivator activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|positive regulation of gene expression|mediator complex|positive regulation of transcription, DNA-templated|core mediator complex" MED27 941.690148 801.1186896 1082.261606 1.350937908 0.433961367 0.079237656 1 7.083206109 9.408847859 9442 mediator complex subunit 27 "GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005829,GO:0006357,GO:0006367,GO:0016592,GO:0045893" "transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytosol|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|mediator complex|positive regulation of transcription, DNA-templated" hsa04919 Thyroid hormone signaling pathway MED28 1233.839472 1203.758862 1263.920082 1.0499778 0.070358825 0.773565714 1 5.91659588 6.108339994 80306 mediator complex subunit 28 "GO:0003779,GO:0005515,GO:0005654,GO:0016020,GO:0016592,GO:0019827,GO:0030864,GO:0051151" actin binding|protein binding|nucleoplasm|membrane|mediator complex|stem cell population maintenance|cortical actin cytoskeleton|negative regulation of smooth muscle cell differentiation MED29 915.584223 986.3123607 844.8560853 0.856580652 -0.223339004 0.36835507 1 14.66230583 12.34928215 55588 mediator complex subunit 29 "GO:0003712,GO:0005515,GO:0005654,GO:0006357,GO:0008134,GO:0016592" transcription coregulator activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription factor binding|mediator complex MED30 582.3781795 502.5199053 662.2364537 1.317831287 0.398165684 0.132272957 1 8.262034428 10.70577208 90390 mediator complex subunit 30 "GO:0000151,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006367,GO:0016567,GO:0016592,GO:0019827,GO:0030374,GO:0042809,GO:0045893,GO:0046966,GO:0060261,GO:0061630" "ubiquitin ligase complex|transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|protein ubiquitination|mediator complex|stem cell population maintenance|nuclear receptor coactivator activity|vitamin D receptor binding|positive regulation of transcription, DNA-templated|thyroid hormone receptor binding|positive regulation of transcription initiation from RNA polymerase II promoter|ubiquitin protein ligase activity" hsa04919 Thyroid hormone signaling pathway MED31 158.8473994 158.1429102 159.5518887 1.008909527 0.012796808 0.992466756 1 5.180967748 5.139658816 51003 mediator complex subunit 31 "GO:0000151,GO:0003712,GO:0005515,GO:0005654,GO:0006357,GO:0006367,GO:0016567,GO:0016592,GO:0048147,GO:0060173,GO:0061630,GO:0070847" ubiquitin ligase complex|transcription coregulator activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|protein ubiquitination|mediator complex|negative regulation of fibroblast proliferation|limb development|ubiquitin protein ligase activity|core mediator complex MED4 793.429941 706.4410263 880.4188557 1.246273677 0.317620914 0.207539274 1 10.68030005 13.08784235 29079 mediator complex subunit 4 "GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006366,GO:0006367,GO:0016020,GO:0016592,GO:0030374,GO:0042809,GO:0045893,GO:0046966,GO:0060261,GO:0070847" "transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|membrane|mediator complex|nuclear receptor coactivator activity|vitamin D receptor binding|positive regulation of transcription, DNA-templated|thyroid hormone receptor binding|positive regulation of transcription initiation from RNA polymerase II promoter|core mediator complex" hsa04919 Thyroid hormone signaling pathway MED6 616.3501465 574.3084632 658.3918299 1.146408023 0.197120611 0.45326428 1 12.92149542 14.56542541 10001 mediator complex subunit 6 "GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006367,GO:0008134,GO:0016020,GO:0016592,GO:0045944,GO:0070847" transcription coactivator activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription factor binding|membrane|mediator complex|positive regulation of transcription by RNA polymerase II|core mediator complex MED7 224.4236565 214.3252598 234.5220533 1.094234312 0.1299217 0.718536686 1 4.676265414 5.031305174 9443 mediator complex subunit 7 "GO:0000151,GO:0003713,GO:0005515,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0016567,GO:0016592,GO:0016604,GO:0019827,GO:0045893,GO:0061630" "ubiquitin ligase complex|transcription coactivator activity|protein binding|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|protein ubiquitination|mediator complex|nuclear body|stem cell population maintenance|positive regulation of transcription, DNA-templated|ubiquitin protein ligase activity" MED8 1171.092577 1083.070852 1259.114302 1.162541029 0.217281633 0.371076194 1 28.74266572 32.8553813 112950 mediator complex subunit 8 "GO:0000978,GO:0003712,GO:0005515,GO:0005654,GO:0006357,GO:0006367,GO:0016567,GO:0016592,GO:0070847" RNA polymerase II cis-regulatory region sequence-specific DNA binding|transcription coregulator activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|protein ubiquitination|mediator complex|core mediator complex MED9 381.3487441 372.46817 390.2293181 1.047685009 0.06720503 0.826768152 1 8.998615511 9.26995454 55090 mediator complex subunit 9 "GO:0003712,GO:0005515,GO:0006357,GO:0016592" transcription coregulator activity|protein binding|regulation of transcription by RNA polymerase II|mediator complex MEF2A 1548.932622 1615.76276 1482.102484 0.917277289 -0.124570174 0.602446543 1 6.499117338 5.861735226 4205 myocyte enhancer factor 2A "GO:0000002,GO:0000122,GO:0000165,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001085,GO:0001228,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006351,GO:0006357,GO:0006915,GO:0007507,GO:0007517,GO:0010613,GO:0019901,GO:0030154,GO:0033613,GO:0035035,GO:0042826,GO:0043565,GO:0045944,GO:0046326,GO:0046332,GO:0046982,GO:0048311,GO:0048813,GO:0051149,GO:0055005,GO:0061337,GO:0070375,GO:0071277" "mitochondrial genome maintenance|negative regulation of transcription by RNA polymerase II|MAPK cascade|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|transcription, DNA-templated|regulation of transcription by RNA polymerase II|apoptotic process|heart development|muscle organ development|positive regulation of cardiac muscle hypertrophy|protein kinase binding|cell differentiation|activating transcription factor binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|positive regulation of glucose import|SMAD binding|protein heterodimerization activity|mitochondrion distribution|dendrite morphogenesis|positive regulation of muscle cell differentiation|ventricular cardiac myofibril assembly|cardiac conduction|ERK5 cascade|cellular response to calcium ion" "hsa04022,hsa04371,hsa04928,hsa05418" "cGMP-PKG signaling pathway|Apelin signaling pathway|Parathyroid hormone synthesis, secretion and action|Fluid shear stress and atherosclerosis" SRF MEF2C 112.52886 115.485941 109.571779 0.948788901 -0.075840962 0.885389223 1 0.695864561 0.649180541 4208 myocyte enhancer factor 2C "GO:0000122,GO:0000165,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001568,GO:0001649,GO:0001764,GO:0001782,GO:0001947,GO:0001958,GO:0001974,GO:0002062,GO:0002467,GO:0002634,GO:0003138,GO:0003139,GO:0003151,GO:0003185,GO:0003211,GO:0003680,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006357,GO:0006915,GO:0006959,GO:0007399,GO:0007507,GO:0007517,GO:0007519,GO:0007521,GO:0007611,GO:0010628,GO:0010629,GO:0010694,GO:0014033,GO:0014902,GO:0016528,GO:0016607,GO:0030154,GO:0030182,GO:0030220,GO:0030279,GO:0030318,GO:0030501,GO:0030890,GO:0032991,GO:0033613,GO:0035690,GO:0035984,GO:0042100,GO:0042826,GO:0043231,GO:0043523,GO:0043524,GO:0043537,GO:0045652,GO:0045663,GO:0045666,GO:0045669,GO:0045893,GO:0045944,GO:0046928,GO:0046982,GO:0048167,GO:0048643,GO:0048666,GO:0048667,GO:0050853,GO:0051145,GO:0051149,GO:0051963,GO:0051966,GO:0055012,GO:0060025,GO:0060045,GO:0060079,GO:0060998,GO:0061333,GO:0071222,GO:0071277,GO:0071374,GO:0071498,GO:0071560,GO:0072102,GO:0072160,GO:0098794,GO:1904706,GO:1904753,GO:1905563,GO:1990837,GO:2000111,GO:2000310,GO:2000311,GO:2000727,GO:2000987,GO:2001013,GO:2001016" "negative regulation of transcription by RNA polymerase II|MAPK cascade|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|blood vessel development|osteoblast differentiation|neuron migration|B cell homeostasis|heart looping|endochondral ossification|blood vessel remodeling|chondrocyte differentiation|germinal center formation|regulation of germinal center formation|primary heart field specification|secondary heart field specification|outflow tract morphogenesis|sinoatrial valve morphogenesis|cardiac ventricle formation|minor groove of adenine-thymine-rich DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|apoptotic process|humoral immune response|nervous system development|heart development|muscle organ development|skeletal muscle tissue development|muscle cell fate determination|learning or memory|positive regulation of gene expression|negative regulation of gene expression|positive regulation of alkaline phosphatase activity|neural crest cell differentiation|myotube differentiation|sarcoplasm|nuclear speck|cell differentiation|neuron differentiation|platelet formation|negative regulation of ossification|melanocyte differentiation|positive regulation of bone mineralization|positive regulation of B cell proliferation|protein-containing complex|activating transcription factor binding|cellular response to drug|cellular response to trichostatin A|B cell proliferation|histone deacetylase binding|intracellular membrane-bounded organelle|regulation of neuron apoptotic process|negative regulation of neuron apoptotic process|negative regulation of blood vessel endothelial cell migration|regulation of megakaryocyte differentiation|positive regulation of myoblast differentiation|positive regulation of neuron differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of neurotransmitter secretion|protein heterodimerization activity|regulation of synaptic plasticity|positive regulation of skeletal muscle tissue development|neuron development|cell morphogenesis involved in neuron differentiation|B cell receptor signaling pathway|smooth muscle cell differentiation|positive regulation of muscle cell differentiation|regulation of synapse assembly|regulation of synaptic transmission, glutamatergic|ventricular cardiac muscle cell differentiation|regulation of synaptic activity|positive regulation of cardiac muscle cell proliferation|excitatory postsynaptic potential|regulation of dendritic spine development|renal tubule morphogenesis|cellular response to lipopolysaccharide|cellular response to calcium ion|cellular response to parathyroid hormone stimulus|cellular response to fluid shear stress|cellular response to transforming growth factor beta stimulus|glomerulus morphogenesis|nephron tubule epithelial cell differentiation|postsynapse|negative regulation of vascular associated smooth muscle cell proliferation|negative regulation of vascular associated smooth muscle cell migration|negative regulation of vascular endothelial cell proliferation|sequence-specific double-stranded DNA binding|positive regulation of macrophage apoptotic process|regulation of NMDA receptor activity|regulation of AMPA receptor activity|positive regulation of cardiac muscle cell differentiation|positive regulation of behavioral fear response|epithelial cell proliferation involved in renal tubule morphogenesis|positive regulation of skeletal muscle cell differentiation" "hsa04010,hsa04022,hsa04371,hsa04921,hsa04928,hsa05202,hsa05418" "MAPK signaling pathway|cGMP-PKG signaling pathway|Apelin signaling pathway|Oxytocin signaling pathway|Parathyroid hormone synthesis, secretion and action|Transcriptional misregulation in cancer|Fluid shear stress and atherosclerosis" SRF MEF2D 1436.958567 1514.842613 1359.074522 0.897172096 -0.156543345 0.513767373 1 11.3274998 9.992657436 4209 myocyte enhancer factor 2D "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001649,GO:0001958,GO:0002062,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006915,GO:0007399,GO:0007512,GO:0007517,GO:0030154,GO:0033613,GO:0035914,GO:0042803,GO:0042826,GO:0043231,GO:0045944,GO:0046982,GO:1904707,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|osteoblast differentiation|endochondral ossification|chondrocyte differentiation|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|apoptotic process|nervous system development|adult heart development|muscle organ development|cell differentiation|activating transcription factor binding|skeletal muscle cell differentiation|protein homodimerization activity|histone deacetylase binding|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|positive regulation of vascular associated smooth muscle cell proliferation|sequence-specific double-stranded DNA binding" "hsa04022,hsa04371,hsa04928" "cGMP-PKG signaling pathway|Apelin signaling pathway|Parathyroid hormone synthesis, secretion and action" MEGF6 350.5521245 371.4277561 329.6764929 0.887592506 -0.172030608 0.571320021 1 2.287641857 1.996516205 1953 multiple EGF like domains 6 "GO:0005509,GO:0005515,GO:0005575,GO:0005576,GO:0008150" calcium ion binding|protein binding|cellular_component|extracellular region|biological_process MEGF8 732.1285815 775.1083426 689.1488204 0.889099991 -0.169582417 0.507315038 1 3.714295381 3.247119133 1954 multiple EGF like domains 8 "GO:0003143,GO:0005509,GO:0005515,GO:0005634,GO:0009887,GO:0009888,GO:0010468,GO:0016021,GO:0030326,GO:0030509,GO:0035108,GO:0042074,GO:0045879,GO:0048704,GO:0048842,GO:0055113,GO:0060971,GO:0060972,GO:0060976,GO:0061371,GO:0070062,GO:0071907,GO:0097094,GO:0097155" embryonic heart tube morphogenesis|calcium ion binding|protein binding|nucleus|animal organ morphogenesis|tissue development|regulation of gene expression|integral component of membrane|embryonic limb morphogenesis|BMP signaling pathway|limb morphogenesis|cell migration involved in gastrulation|negative regulation of smoothened signaling pathway|embryonic skeletal system morphogenesis|positive regulation of axon extension involved in axon guidance|epiboly involved in gastrulation with mouth forming second|embryonic heart tube left/right pattern formation|left/right pattern formation|coronary vasculature development|determination of heart left/right asymmetry|extracellular exosome|determination of digestive tract left/right asymmetry|craniofacial suture morphogenesis|fasciculation of sensory neuron axon hsa04340 Hedgehog signaling pathway MEGF9 1203.334732 1273.466592 1133.202872 0.889856773 -0.16835495 0.487843215 1 10.78770976 9.438881685 1955 multiple EGF like domains 9 "GO:0005575,GO:0005604,GO:0008150,GO:0009887,GO:0009888,GO:0016021,GO:0016477,GO:0034446" cellular_component|basement membrane|biological_process|animal organ morphogenesis|tissue development|integral component of membrane|cell migration|substrate adhesion-dependent cell spreading MEI1 29.82540276 26.01034707 33.64045846 1.29334908 0.371111717 0.637830436 1 0.296925009 0.377601504 150365 meiotic double-stranded break formation protein 1 GO:0007127 meiosis I MEIG1 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.219466311 0 644890 meiosis/spermiogenesis associated 1 "GO:0002177,GO:0005515,GO:0005634,GO:0005829,GO:0007288,GO:0034613,GO:1905198" manchette|protein binding|nucleus|cytosol|sperm axoneme assembly|cellular protein localization|manchette assembly MEIOSIN 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.055248733 0.050185843 388553 meiosis initiator "GO:0003677,GO:0005634,GO:0006357,GO:0007283,GO:0046983,GO:0048477,GO:0051321,GO:0071300,GO:0090427" DNA binding|nucleus|regulation of transcription by RNA polymerase II|spermatogenesis|protein dimerization activity|oogenesis|meiotic cell cycle|cellular response to retinoic acid|activation of meiosis MEIS1 73.77565087 82.19269673 65.35860501 0.7951875 -0.330633017 0.536843374 1 0.960681814 0.751138966 4211 Meis homeobox 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001525,GO:0001654,GO:0002089,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005667,GO:0006357,GO:0007420,GO:0007626,GO:0008284,GO:0009880,GO:0009887,GO:0030097,GO:0035855,GO:0045638,GO:0045665,GO:0045944,GO:0060044,GO:0060216" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|eye development|lens morphogenesis in camera-type eye|DNA binding|chromatin binding|protein binding|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|brain development|locomotory behavior|positive regulation of cell population proliferation|embryonic pattern specification|animal organ morphogenesis|hemopoiesis|megakaryocyte development|negative regulation of myeloid cell differentiation|negative regulation of neuron differentiation|positive regulation of transcription by RNA polymerase II|negative regulation of cardiac muscle cell proliferation|definitive hemopoiesis" "hsa04550,hsa05202" Signaling pathways regulating pluripotency of stem cells|Transcriptional misregulation in cancer Homeobox MEIS2 303.3221189 304.8412676 301.8029702 0.990033182 -0.014451215 0.974992643 1 2.954743585 2.876343357 4212 Meis homeobox 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001654,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0007420,GO:0008134,GO:0008284,GO:0008542,GO:0009612,GO:0009880,GO:0009887,GO:0031016,GO:0045638,GO:0045931,GO:0045944,GO:0048471,GO:0070848,GO:0110024,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|eye development|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|brain development|transcription factor binding|positive regulation of cell population proliferation|visual learning|response to mechanical stimulus|embryonic pattern specification|animal organ morphogenesis|pancreas development|negative regulation of myeloid cell differentiation|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|response to growth factor|positive regulation of cardiac muscle myoblast proliferation|sequence-specific double-stranded DNA binding" Homeobox MEIS3 135.4827465 99.87973273 171.0857602 1.712917681 0.77645582 0.065484403 1 1.892896934 3.188119844 56917 Meis homeobox 3 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001654,GO:0005634,GO:0006357,GO:0007420,GO:0008284,GO:0009880,GO:0009887,GO:0043565,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|eye development|nucleus|regulation of transcription by RNA polymerase II|brain development|positive regulation of cell population proliferation|embryonic pattern specification|animal organ morphogenesis|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" MELK 3183.389231 3079.625093 3287.153369 1.067387513 0.094084039 0.692070475 1 60.44646233 63.44014766 9833 maternal embryonic leucine zipper kinase "GO:0000086,GO:0004674,GO:0004715,GO:0005509,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005886,GO:0005938,GO:0006468,GO:0006915,GO:0008283,GO:0008289,GO:0008631,GO:0016020,GO:0018108,GO:0030097,GO:0035556,GO:0043065,GO:0046777,GO:0061351,GO:0106310,GO:0106311" G2/M transition of mitotic cell cycle|protein serine/threonine kinase activity|non-membrane spanning protein tyrosine kinase activity|calcium ion binding|protein binding|ATP binding|nucleus|cytoplasm|plasma membrane|cell cortex|protein phosphorylation|apoptotic process|cell population proliferation|lipid binding|intrinsic apoptotic signaling pathway in response to oxidative stress|membrane|peptidyl-tyrosine phosphorylation|hemopoiesis|intracellular signal transduction|positive regulation of apoptotic process|protein autophosphorylation|neural precursor cell proliferation|protein serine kinase activity|protein threonine kinase activity MELTF 3981.652677 4114.836906 3848.468448 0.935266339 -0.09655083 0.685673026 1 43.15214834 39.68340274 4241 melanotransferrin "GO:0001558,GO:0005506,GO:0005515,GO:0005576,GO:0005615,GO:0005769,GO:0005788,GO:0005886,GO:0006826,GO:0009986,GO:0010756,GO:0042127,GO:0043687,GO:0044267,GO:0046658,GO:0055037,GO:0055072,GO:0070062,GO:0090091,GO:1900025" regulation of cell growth|iron ion binding|protein binding|extracellular region|extracellular space|early endosome|endoplasmic reticulum lumen|plasma membrane|iron ion transport|cell surface|positive regulation of plasminogen activation|regulation of cell population proliferation|post-translational protein modification|cellular protein metabolic process|anchored component of plasma membrane|recycling endosome|iron ion homeostasis|extracellular exosome|positive regulation of extracellular matrix disassembly|negative regulation of substrate adhesion-dependent cell spreading MEMO1 398.5753238 357.9023756 439.2482719 1.227285153 0.29547049 0.308714877 1 5.985769975 7.223317132 51072 mediator of cell motility 1 "GO:0005515,GO:0005634,GO:0005829,GO:0032886,GO:2000145" protein binding|nucleus|cytosol|regulation of microtubule-based process|regulation of cell motility MEN1 1116.692916 1118.444924 1114.940909 0.996867065 -0.004526964 0.989346251 1 15.84532784 15.53136606 4221 menin 1 "GO:0000122,GO:0000165,GO:0000400,GO:0000403,GO:0000781,GO:0000785,GO:0000976,GO:0001933,GO:0002076,GO:0003682,GO:0003690,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005788,GO:0005829,GO:0006281,GO:0006357,GO:0006974,GO:0008285,GO:0009411,GO:0010332,GO:0016363,GO:0018024,GO:0030511,GO:0030674,GO:0032092,GO:0032154,GO:0032991,GO:0034968,GO:0035097,GO:0043433,GO:0043687,GO:0044267,GO:0045668,GO:0045736,GO:0045786,GO:0045892,GO:0045944,GO:0046329,GO:0047485,GO:0051974,GO:0070412,GO:1904837" "negative regulation of transcription by RNA polymerase II|MAPK cascade|four-way junction DNA binding|Y-form DNA binding|chromosome, telomeric region|chromatin|transcription regulatory region sequence-specific DNA binding|negative regulation of protein phosphorylation|osteoblast development|chromatin binding|double-stranded DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum lumen|cytosol|DNA repair|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|negative regulation of cell population proliferation|response to UV|response to gamma radiation|nuclear matrix|histone-lysine N-methyltransferase activity|positive regulation of transforming growth factor beta receptor signaling pathway|protein-macromolecule adaptor activity|positive regulation of protein binding|cleavage furrow|protein-containing complex|histone lysine methylation|histone methyltransferase complex|negative regulation of DNA-binding transcription factor activity|post-translational protein modification|cellular protein metabolic process|negative regulation of osteoblast differentiation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of JNK cascade|protein N-terminus binding|negative regulation of telomerase activity|R-SMAD binding|beta-catenin-TCF complex assembly" "hsa04934,hsa05202" Cushing syndrome|Transcriptional misregulation in cancer MEOX1 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.06079377 0 4222 mesenchyme homeobox 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001757,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0007275,GO:0008150,GO:0043565,GO:0045944,GO:0060218,GO:0061053,GO:0061056,GO:0071837,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|somite specification|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|multicellular organism development|biological_process|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|hematopoietic stem cell differentiation|somite development|sclerotome development|HMG box domain binding|sequence-specific double-stranded DNA binding" MEPCE 749.2060918 832.3311061 666.0810775 0.800259744 -0.321459758 0.205255171 1 14.78202375 11.63150857 56257 methylphosphate capping enzyme "GO:0000122,GO:0001510,GO:0003723,GO:0005515,GO:0005634,GO:0008171,GO:0008173,GO:0008757,GO:0016073,GO:0017069,GO:0035562,GO:0040031,GO:0097322,GO:0120259,GO:1900087,GO:1904871,GO:1905382,GO:1990276,GO:1990904" negative regulation of transcription by RNA polymerase II|RNA methylation|RNA binding|protein binding|nucleus|O-methyltransferase activity|RNA methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|snRNA metabolic process|snRNA binding|negative regulation of chromatin binding|snRNA modification|7SK snRNA binding|7SK snRNP|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of protein localization to Cajal body|positive regulation of snRNA transcription by RNA polymerase II|RNA 5'-methyltransferase activity|ribonucleoprotein complex MERTK 528.6421503 580.5509465 476.7333542 0.821174019 -0.284240111 0.292920684 1 8.097997127 6.538588367 10461 "MER proto-oncogene, tyrosine kinase" "GO:0001750,GO:0001779,GO:0001818,GO:0004714,GO:0005515,GO:0005524,GO:0005615,GO:0005737,GO:0005886,GO:0005887,GO:0006468,GO:0006909,GO:0007166,GO:0007169,GO:0007267,GO:0007275,GO:0007283,GO:0007399,GO:0016028,GO:0016477,GO:0018108,GO:0030168,GO:0032940,GO:0033674,GO:0034446,GO:0043235,GO:0043491,GO:0050766,GO:0050900,GO:0051250,GO:0060041,GO:0060068,GO:0097350,GO:2000107" photoreceptor outer segment|natural killer cell differentiation|negative regulation of cytokine production|transmembrane receptor protein tyrosine kinase activity|protein binding|ATP binding|extracellular space|cytoplasm|plasma membrane|integral component of plasma membrane|protein phosphorylation|phagocytosis|cell surface receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|cell-cell signaling|multicellular organism development|spermatogenesis|nervous system development|rhabdomere|cell migration|peptidyl-tyrosine phosphorylation|platelet activation|secretion by cell|positive regulation of kinase activity|substrate adhesion-dependent cell spreading|receptor complex|protein kinase B signaling|positive regulation of phagocytosis|leukocyte migration|negative regulation of lymphocyte activation|retina development in camera-type eye|vagina development|neutrophil clearance|negative regulation of leukocyte apoptotic process MESD 810.3388746 784.4720675 836.2056817 1.065947044 0.092135768 0.717393723 1 9.968055344 10.44761713 23184 mesoderm development LRP chaperone "GO:0001503,GO:0003674,GO:0005515,GO:0005783,GO:0005886,GO:0006457,GO:0006909,GO:0007498,GO:0016055,GO:0034394,GO:0042802,GO:0050750,GO:1904395" ossification|molecular_function|protein binding|endoplasmic reticulum|plasma membrane|protein folding|phagocytosis|mesoderm development|Wnt signaling pathway|protein localization to cell surface|identical protein binding|low-density lipoprotein particle receptor binding|positive regulation of skeletal muscle acetylcholine-gated channel clustering MESP1 32.99130379 20.80827765 45.17432993 2.170978814 1.118345647 0.112866488 1 0.955679462 2.040041567 55897 mesoderm posterior bHLH transcription factor 1 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001707,GO:0001947,GO:0003007,GO:0003139,GO:0003143,GO:0003210,GO:0003211,GO:0003236,GO:0003241,GO:0003259,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0007219,GO:0007369,GO:0008078,GO:0010467,GO:0022008,GO:0023019,GO:0032525,GO:0035481,GO:0042662,GO:0042664,GO:0045446,GO:0045747,GO:0045892,GO:0045893,GO:0045944,GO:0046983,GO:0048368,GO:0051155,GO:0055007,GO:0060913,GO:0060921,GO:0060947,GO:0060975,GO:0070368,GO:0090082" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|mesoderm formation|heart looping|heart morphogenesis|secondary heart field specification|embryonic heart tube morphogenesis|cardiac atrium formation|cardiac ventricle formation|sinus venosus morphogenesis|growth involved in heart morphogenesis|cardioblast anterior-lateral migration|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|Notch signaling pathway|gastrulation|mesodermal cell migration|gene expression|neurogenesis|signal transduction involved in regulation of gene expression|somite rostral/caudal axis specification|positive regulation of Notch signaling pathway involved in heart induction|negative regulation of mesodermal cell fate specification|negative regulation of endodermal cell fate specification|endothelial cell differentiation|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|lateral mesoderm development|positive regulation of striated muscle cell differentiation|cardiac muscle cell differentiation|cardiac cell fate determination|sinoatrial node cell differentiation|cardiac vascular smooth muscle cell differentiation|cardioblast migration to the midline involved in heart field formation|positive regulation of hepatocyte differentiation|positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway" MET 9514.42137 10092.01466 8936.828079 0.885534591 -0.175379431 0.483350173 1 76.11535813 66.27488827 4233 "MET proto-oncogene, receptor tyrosine kinase" "GO:0000165,GO:0001886,GO:0001889,GO:0004713,GO:0004714,GO:0005008,GO:0005515,GO:0005524,GO:0005576,GO:0005886,GO:0005887,GO:0006909,GO:0007165,GO:0007166,GO:0007169,GO:0007275,GO:0007399,GO:0009925,GO:0009986,GO:0010507,GO:0016021,GO:0016477,GO:0017154,GO:0018108,GO:0019903,GO:0030182,GO:0031016,GO:0031116,GO:0033674,GO:0035024,GO:0035635,GO:0042802,GO:0043235,GO:0045944,GO:0048012,GO:0048754,GO:0050918,GO:0051497,GO:0051897,GO:0061436,GO:0070495,GO:0071526,GO:1901299,GO:1905098,GO:2001028" MAPK cascade|endothelial cell morphogenesis|liver development|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|hepatocyte growth factor-activated receptor activity|protein binding|ATP binding|extracellular region|plasma membrane|integral component of plasma membrane|phagocytosis|signal transduction|cell surface receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|nervous system development|basal plasma membrane|cell surface|negative regulation of autophagy|integral component of membrane|cell migration|semaphorin receptor activity|peptidyl-tyrosine phosphorylation|protein phosphatase binding|neuron differentiation|pancreas development|positive regulation of microtubule polymerization|positive regulation of kinase activity|negative regulation of Rho protein signal transduction|entry of bacterium into host cell|identical protein binding|receptor complex|positive regulation of transcription by RNA polymerase II|hepatocyte growth factor receptor signaling pathway|branching morphogenesis of an epithelial tube|positive chemotaxis|negative regulation of stress fiber assembly|positive regulation of protein kinase B signaling|establishment of skin barrier|negative regulation of thrombin-activated receptor signaling pathway|semaphorin-plexin signaling pathway|negative regulation of hydrogen peroxide-mediated programmed cell death|negative regulation of guanyl-nucleotide exchange factor activity|positive regulation of endothelial cell chemotaxis "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04360,hsa04510,hsa04520,hsa05100,hsa05120,hsa05144,hsa05200,hsa05202,hsa05205,hsa05206,hsa05211,hsa05218,hsa05223,hsa05225,hsa05226,hsa05230" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Axon guidance|Focal adhesion|Adherens junction|Bacterial invasion of epithelial cells|Epithelial cell signaling in Helicobacter pylori infection|Malaria|Pathways in cancer|Transcriptional misregulation in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Renal cell carcinoma|Melanoma|Non-small cell lung cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer METAP1 1923.534381 1836.330503 2010.73826 1.094976235 0.130899558 0.581328797 1 17.68343268 19.03892598 23173 methionyl aminopeptidase 1 "GO:0004177,GO:0005515,GO:0005737,GO:0005829,GO:0006417,GO:0006508,GO:0008235,GO:0018206,GO:0022400,GO:0031365,GO:0046872,GO:0070006,GO:0070084,GO:0070527" aminopeptidase activity|protein binding|cytoplasm|cytosol|regulation of translation|proteolysis|metalloexopeptidase activity|peptidyl-methionine modification|regulation of rhodopsin mediated signaling pathway|N-terminal protein amino acid modification|metal ion binding|metalloaminopeptidase activity|protein initiator methionine removal|platelet aggregation METAP1D 196.6935584 255.9418151 137.4453017 0.537017766 -0.896958278 0.014331148 0.708244576 4.160567856 2.196910889 254042 "methionyl aminopeptidase type 1D, mitochondrial" "GO:0004177,GO:0005739,GO:0006508,GO:0008235,GO:0018206,GO:0031365,GO:0046872,GO:0070006,GO:0070084" aminopeptidase activity|mitochondrion|proteolysis|metalloexopeptidase activity|peptidyl-methionine modification|N-terminal protein amino acid modification|metal ion binding|metalloaminopeptidase activity|protein initiator methionine removal METAP2 2269.366243 1995.513827 2543.21866 1.274468072 0.349895231 0.138908329 1 31.32261922 39.25167637 10988 methionyl aminopeptidase 2 "GO:0003723,GO:0004177,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0008235,GO:0016485,GO:0018206,GO:0022400,GO:0031365,GO:0046872,GO:0070006,GO:0070084" RNA binding|aminopeptidase activity|protein binding|cytoplasm|cytosol|plasma membrane|metalloexopeptidase activity|protein processing|peptidyl-methionine modification|regulation of rhodopsin mediated signaling pathway|N-terminal protein amino acid modification|metal ion binding|metalloaminopeptidase activity|protein initiator methionine removal METRN 686.7913197 682.511507 691.0711324 1.012541364 0.017980846 0.950376624 1 10.96459504 10.91632731 79006 "meteorin, glial cell differentiation regulator" "GO:0005179,GO:0005615,GO:0007165,GO:0010001,GO:0050772" hormone activity|extracellular space|signal transduction|glial cell differentiation|positive regulation of axonogenesis METRNL 1996.886632 1478.428127 2515.345137 1.701364504 0.76669226 0.001254473 0.22279115 28.54594498 47.75435357 284207 "meteorin like, glial cell differentiation regulator" "GO:0003674,GO:0005179,GO:0005615,GO:0007165,GO:0009409,GO:0014850,GO:0045444,GO:0050728,GO:0050873,GO:0070062,GO:0090336,GO:0097009" molecular_function|hormone activity|extracellular space|signal transduction|response to cold|response to muscle activity|fat cell differentiation|negative regulation of inflammatory response|brown fat cell differentiation|extracellular exosome|positive regulation of brown fat cell differentiation|energy homeostasis METTL1 196.7482786 219.5273292 173.969228 0.792471847 -0.335568412 0.361476016 1 7.63242351 5.94726762 4234 methyltransferase like 1 "GO:0000049,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006400,GO:0008176,GO:0030488,GO:0036265,GO:0043527,GO:0106004" tRNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|tRNA modification|tRNA (guanine-N7-)-methyltransferase activity|tRNA methylation|RNA (guanine-N7)-methylation|tRNA methyltransferase complex|tRNA (guanine-N7)-methylation METTL14 638.9322811 586.7934298 691.0711324 1.177707686 0.235981498 0.365319553 1 4.667772674 5.405282356 57721 methyltransferase like 14 "GO:0000398,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0006402,GO:0007283,GO:0016070,GO:0016422,GO:0019827,GO:0021861,GO:0036396,GO:0042063,GO:0045727,GO:0061157,GO:0080009,GO:1901533,GO:1904047" "mRNA splicing, via spliceosome|mRNA binding|protein binding|nucleus|nucleoplasm|mRNA catabolic process|spermatogenesis|RNA metabolic process|mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|stem cell population maintenance|forebrain radial glial cell differentiation|RNA N6-methyladenosine methyltransferase complex|gliogenesis|positive regulation of translation|mRNA destabilization|mRNA methylation|negative regulation of hematopoietic progenitor cell differentiation|S-adenosyl-L-methionine binding" METTL15 341.8721528 345.417409 338.3268965 0.979472625 -0.029922923 0.931412534 1 4.296036418 4.137437397 196074 methyltransferase like 15 "GO:0005759,GO:0070475,GO:0071424" mitochondrial matrix|rRNA base methylation|rRNA (cytosine-N4-)-methyltransferase activity METTL16 667.0379328 706.4410263 627.6348393 0.888446191 -0.170643693 0.51081984 1 6.388994948 5.5812934 79066 methyltransferase like 16 "GO:0001734,GO:0003723,GO:0005634,GO:0005737,GO:0006402,GO:0006556,GO:0010608,GO:0030629,GO:0035613,GO:0048024,GO:0052907,GO:0061157,GO:0070475,GO:0080009,GO:0120048,GO:0120049,GO:1905869" "mRNA (N6-adenosine)-methyltransferase activity|RNA binding|nucleus|cytoplasm|mRNA catabolic process|S-adenosylmethionine biosynthetic process|posttranscriptional regulation of gene expression|U6 snRNA 3'-end binding|RNA stem-loop binding|regulation of mRNA splicing, via spliceosome|23S rRNA (adenine(1618)-N(6))-methyltransferase activity|mRNA destabilization|rRNA base methylation|mRNA methylation|U6 snRNA (adenine-(43)-N(6))-methyltransferase activity|snRNA (adenine-N6)-methylation|negative regulation of 3'-UTR-mediated mRNA stabilization" METTL17 806.737055 778.2295842 835.2445258 1.073262367 0.102002797 0.688256078 1 25.26318892 26.66031337 64745 methyltransferase like 17 "GO:0005515,GO:0005654,GO:0005739,GO:0005759,GO:0006412,GO:0008168,GO:0032259,GO:0042274,GO:1904047" protein binding|nucleoplasm|mitochondrion|mitochondrial matrix|translation|methyltransferase activity|methylation|ribosomal small subunit biogenesis|S-adenosyl-L-methionine binding METTL18 123.3393493 121.7284243 124.9502743 1.026467524 0.037687984 0.951270879 1 3.120279671 3.149270128 92342 methyltransferase like 18 "GO:0005515,GO:0008150,GO:0018064,GO:0031072,GO:0032991,GO:0042038" "protein binding|biological_process|protein-histidine N-methyltransferase activity|heat shock protein binding|protein-containing complex|peptidyl-histidine methylation, to form tele-methylhistidine" METTL21A 347.6195812 294.4371288 400.8020336 1.361248275 0.444930221 0.139430719 1 2.251872802 3.014063353 151194 methyltransferase like 21A "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006479,GO:0008276,GO:0016279,GO:0018022,GO:0030544,GO:0031072,GO:0032991,GO:0043462,GO:0051117" protein binding|nucleoplasm|cytoplasm|cytosol|protein methylation|protein methyltransferase activity|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation|Hsp70 protein binding|heat shock protein binding|protein-containing complex|regulation of ATPase activity|ATPase binding METTL22 338.869798 342.2961674 335.4434286 0.979980089 -0.029175657 0.933669122 1 2.557071296 2.463946466 79091 methyltransferase like 22 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006479,GO:0008276,GO:0016279,GO:0018022,GO:0031072,GO:0032991" protein binding|nucleus|nucleoplasm|nucleolus|protein methylation|protein methyltransferase activity|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation|heat shock protein binding|protein-containing complex METTL23 646.973159 608.6421213 685.3041966 1.125955915 0.171150342 0.511906781 1 22.40145612 24.80097841 124512 methyltransferase like 23 "GO:0005515,GO:0005634,GO:0005737,GO:0008134,GO:0008168,GO:0016021,GO:0031072,GO:0032259,GO:0032991,GO:0045944,GO:0050890" protein binding|nucleus|cytoplasm|transcription factor binding|methyltransferase activity|integral component of membrane|heat shock protein binding|methylation|protein-containing complex|positive regulation of transcription by RNA polymerase II|cognition METTL25 65.65048462 70.74814402 60.55282523 0.855892774 -0.224498028 0.698616173 1 0.239757329 0.201772711 84190 methyltransferase like 25 "GO:0008168,GO:0032259" methyltransferase activity|methylation METTL26 527.6665175 517.0856997 538.2473354 1.040924813 0.057865865 0.836784246 1 30.93712268 31.66434139 84326 methyltransferase like 26 METTL27 398.9514917 418.2463808 379.6566026 0.90773434 -0.139657958 0.634570246 1 19.24227641 17.17459059 155368 methyltransferase like 27 "GO:0005515,GO:0008168" protein binding|methyltransferase activity METTL2A 627.6261226 618.0058463 637.2463988 1.031133286 0.044230829 0.871279256 1 5.66698216 5.745632315 339175 methyltransferase like 2A "GO:0016427,GO:0030488,GO:0052735" tRNA (cytosine) methyltransferase activity|tRNA methylation|tRNA (cytosine-3-)-methyltransferase activity METTL2B 978.2921035 1005.039811 951.5443964 0.946772841 -0.078909774 0.751868249 1 9.182867233 8.548605485 55798 methyltransferase like 2B "GO:0016427,GO:0030488,GO:0052735" tRNA (cytosine) methyltransferase activity|tRNA methylation|tRNA (cytosine-3-)-methyltransferase activity METTL3 1229.667756 1220.405484 1238.930027 1.015179007 0.02173414 0.931887897 1 33.38328944 33.32291111 56339 methyltransferase like 3 "GO:0000398,GO:0001510,GO:0001734,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006382,GO:0006397,GO:0006402,GO:0006974,GO:0007283,GO:0007623,GO:0008168,GO:0008173,GO:0009048,GO:0016070,GO:0016422,GO:0016607,GO:0019827,GO:0021861,GO:0031053,GO:0034644,GO:0036396,GO:0042063,GO:0045087,GO:0045580,GO:0045727,GO:0045746,GO:0046982,GO:0051445,GO:0060339,GO:0061157,GO:0080009,GO:0098508,GO:1902036,GO:1903679,GO:1904047,GO:1990744" "mRNA splicing, via spliceosome|RNA methylation|mRNA (N6-adenosine)-methyltransferase activity|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|adenosine to inosine editing|mRNA processing|mRNA catabolic process|cellular response to DNA damage stimulus|spermatogenesis|circadian rhythm|methyltransferase activity|RNA methyltransferase activity|dosage compensation by inactivation of X chromosome|RNA metabolic process|mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|nuclear speck|stem cell population maintenance|forebrain radial glial cell differentiation|primary miRNA processing|cellular response to UV|RNA N6-methyladenosine methyltransferase complex|gliogenesis|innate immune response|regulation of T cell differentiation|positive regulation of translation|negative regulation of Notch signaling pathway|protein heterodimerization activity|regulation of meiotic cell cycle|negative regulation of type I interferon-mediated signaling pathway|mRNA destabilization|mRNA methylation|endothelial to hematopoietic transition|regulation of hematopoietic stem cell differentiation|positive regulation of cap-independent translational initiation|S-adenosyl-L-methionine binding|primary miRNA methylation" METTL4 715.4027015 739.7342706 691.0711324 0.93421538 -0.098172899 0.704503223 1 10.95705202 10.06495679 64863 methyltransferase like 4 "GO:0001510,GO:0003676,GO:0005634,GO:0005759,GO:0005829,GO:0006325,GO:0008168,GO:0008173,GO:0009007,GO:0032775,GO:0043484,GO:0090296,GO:0120049,GO:1902275,GO:1903108" RNA methylation|nucleic acid binding|nucleus|mitochondrial matrix|cytosol|chromatin organization|methyltransferase activity|RNA methyltransferase activity|site-specific DNA-methyltransferase (adenine-specific) activity|DNA methylation on adenine|regulation of RNA splicing|regulation of mitochondrial DNA replication|snRNA (adenine-N6)-methylation|regulation of chromatin organization|regulation of mitochondrial transcription METTL5 925.0781245 781.3508259 1068.805423 1.367894405 0.451956865 0.068057931 1 48.48750874 65.21591961 29081 methyltransferase like 5 "GO:0003676,GO:0005515,GO:0005634,GO:0008988,GO:0031167,GO:0042995,GO:0045727,GO:0048863,GO:0098793,GO:0098794,GO:1904047" nucleic acid binding|protein binding|nucleus|rRNA (adenine-N6-)-methyltransferase activity|rRNA methylation|cell projection|positive regulation of translation|stem cell differentiation|presynapse|postsynapse|S-adenosyl-L-methionine binding METTL6 417.7386922 406.8018281 428.6755564 1.053769985 0.075559993 0.798788582 1 2.068038283 2.142770097 131965 methyltransferase like 6 "GO:0005515,GO:0005575,GO:0019899,GO:0030488,GO:0052735" protein binding|cellular_component|enzyme binding|tRNA methylation|tRNA (cytosine-3-)-methyltransferase activity METTL7A 11.85090318 8.323311061 15.3784953 1.847641543 0.88568489 0.430428857 1 0.142508763 0.258899056 25840 methyltransferase like 7A "GO:0005515,GO:0005576,GO:0005783,GO:0005811,GO:0008168,GO:0016020,GO:0032259,GO:0043312,GO:1904724" protein binding|extracellular region|endoplasmic reticulum|lipid droplet|methyltransferase activity|membrane|methylation|neutrophil degranulation|tertiary granule lumen METTL7B 48.71639892 55.14193578 42.29086206 0.766945546 -0.382803946 0.541796747 1 2.236188272 1.686335854 196410 methyltransferase like 7B "GO:0008168,GO:0032259" methyltransferase activity|methylation METTL8 508.6761418 535.8131496 481.539134 0.898707197 -0.154076939 0.574988104 1 2.794153118 2.469105233 79828 methyltransferase like 8 "GO:0005634,GO:0005737,GO:0008174,GO:0030488,GO:0052735,GO:0080009" nucleus|cytoplasm|mRNA methyltransferase activity|tRNA methylation|tRNA (cytosine-3-)-methyltransferase activity|mRNA methylation METTL9 2746.905425 2281.627645 3212.183205 1.40784725 0.493490811 0.037155467 0.976206556 37.51271532 51.92843291 51108 methyltransferase like 9 GO:0005515 protein binding MEX3A 278.3421249 279.8713344 276.8129153 0.989072053 -0.015852471 0.97329198 1 2.266153655 2.203882634 92312 mex-3 RNA binding family member A "GO:0000932,GO:0003723,GO:0005634,GO:0005829,GO:0046872" P-body|RNA binding|nucleus|cytosol|metal ion binding MEX3B 85.10634711 89.47559391 80.7371003 0.902336568 -0.148262442 0.78426403 1 1.402392951 1.244255177 84206 mex-3 RNA binding family member B "GO:0000932,GO:0003723,GO:0005509,GO:0005654,GO:0005829,GO:0006468,GO:0046777" P-body|RNA binding|calcium ion binding|nucleoplasm|cytosol|protein phosphorylation|protein autophosphorylation MEX3C 1901.416505 2063.140729 1739.69228 0.843225213 -0.24601009 0.298996497 1 26.5828172 22.04021197 51320 mex-3 RNA binding family member C "GO:0003415,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0016567,GO:0045598,GO:0046872,GO:0061630,GO:0097009" chondrocyte hypertrophy|RNA binding|protein binding|nucleus|cytoplasm|protein ubiquitination|regulation of fat cell differentiation|metal ion binding|ubiquitin protein ligase activity|energy homeostasis MEX3D 527.845155 471.3074888 584.3828212 1.239918387 0.310245163 0.251105222 1 7.168086193 8.739115872 399664 mex-3 RNA binding family member D "GO:0003723,GO:0005634,GO:0010609,GO:0035925,GO:0046872,GO:0048471,GO:0061157" RNA binding|nucleus|mRNA localization resulting in posttranscriptional regulation of gene expression|mRNA 3'-UTR AU-rich region binding|metal ion binding|perinuclear region of cytoplasm|mRNA destabilization MFAP1 602.0466637 589.9146715 614.1786559 1.041131346 0.058152086 0.830642336 1 15.41001556 15.77537814 4236 microfibril associated protein 1 "GO:0000398,GO:0001527,GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005684,GO:0005813,GO:0071005" "mRNA splicing, via spliceosome|microfibril|RNA binding|protein binding|extracellular region|nucleus|nucleoplasm|U2-type spliceosomal complex|centrosome|U2-type precatalytic spliceosome" MFAP2 205.7308052 190.3957405 221.0658699 1.161086216 0.215475103 0.555677287 1 9.113067928 10.40399789 4237 microfibril associated protein 2 "GO:0001527,GO:0005201,GO:0005515,GO:0005576,GO:0030198,GO:0048048,GO:0048050,GO:0062023,GO:0120162" microfibril|extracellular matrix structural constituent|protein binding|extracellular region|extracellular matrix organization|embryonic eye morphogenesis|post-embryonic eye morphogenesis|collagen-containing extracellular matrix|positive regulation of cold-induced thermogenesis MFAP3 723.0913347 840.6544172 605.5282523 0.7203058 -0.473318574 0.06331674 1 8.906924993 6.308351516 4238 microfibril associated protein 3 "GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005886,GO:0016021" protein binding|extracellular region|nucleus|cytoplasm|plasma membrane|integral component of membrane MFAP3L 94.86636168 118.6071826 71.12554074 0.599673133 -0.737751758 0.121498285 1 0.60735438 0.358119474 9848 microfibril associated protein 3 like "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0016021,GO:0030054" protein binding|nucleus|nucleoplasm|cytoplasm|plasma membrane|integral component of membrane|cell junction MFF 1941.083023 1817.603053 2064.562993 1.135871218 0.183799275 0.438007988 1 41.73930048 46.61712007 56947 mitochondrial fission factor "GO:0000266,GO:0001836,GO:0005515,GO:0005739,GO:0005741,GO:0005777,GO:0006626,GO:0008021,GO:0008053,GO:0010821,GO:0016559,GO:0031307,GO:0032592,GO:0032991,GO:0042802,GO:0042803,GO:0043653,GO:0070584,GO:0090141,GO:0090200,GO:0090314,GO:1900063" mitochondrial fission|release of cytochrome c from mitochondria|protein binding|mitochondrion|mitochondrial outer membrane|peroxisome|protein targeting to mitochondrion|synaptic vesicle|mitochondrial fusion|regulation of mitochondrion organization|peroxisome fission|integral component of mitochondrial outer membrane|integral component of mitochondrial membrane|protein-containing complex|identical protein binding|protein homodimerization activity|mitochondrial fragmentation involved in apoptotic process|mitochondrion morphogenesis|positive regulation of mitochondrial fission|positive regulation of release of cytochrome c from mitochondria|positive regulation of protein targeting to membrane|regulation of peroxisome organization MFGE8 1036.50179 956.1403581 1116.863221 1.16809547 0.224158192 0.361027418 1 10.29194304 11.82080062 4240 milk fat globule EGF and factor V/VIII domain containing "GO:0001525,GO:0001786,GO:0005178,GO:0005201,GO:0005576,GO:0005615,GO:0005788,GO:0006910,GO:0006911,GO:0007155,GO:0007338,GO:0008429,GO:0009897,GO:0016020,GO:0019897,GO:0043277,GO:0043687,GO:0044267,GO:0050766,GO:0062023,GO:0070062,GO:1903561" "angiogenesis|phosphatidylserine binding|integrin binding|extracellular matrix structural constituent|extracellular region|extracellular space|endoplasmic reticulum lumen|phagocytosis, recognition|phagocytosis, engulfment|cell adhesion|single fertilization|phosphatidylethanolamine binding|external side of plasma membrane|membrane|extrinsic component of plasma membrane|apoptotic cell clearance|post-translational protein modification|cellular protein metabolic process|positive regulation of phagocytosis|collagen-containing extracellular matrix|extracellular exosome|extracellular vesicle" MFHAS1 733.8672255 833.37152 634.362931 0.761200636 -0.393651328 0.121724527 1 7.017277745 5.252172572 9258 malignant fibrous histiocytoma amplified sequence 1 "GO:0005515,GO:0005525,GO:0005737,GO:0005739,GO:0005764,GO:0005856,GO:0006954,GO:0030218,GO:0031625,GO:0034136,GO:0034137,GO:0034144,GO:0035308,GO:0043030,GO:0045087,GO:0046330,GO:0050728,GO:0051721,GO:0051897,GO:0070374,GO:1900181,GO:1900745" protein binding|GTP binding|cytoplasm|mitochondrion|lysosome|cytoskeleton|inflammatory response|erythrocyte differentiation|ubiquitin protein ligase binding|negative regulation of toll-like receptor 2 signaling pathway|positive regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of protein dephosphorylation|regulation of macrophage activation|innate immune response|positive regulation of JNK cascade|negative regulation of inflammatory response|protein phosphatase 2A binding|positive regulation of protein kinase B signaling|positive regulation of ERK1 and ERK2 cascade|negative regulation of protein localization to nucleus|positive regulation of p38MAPK cascade MFN1 1351.471022 1377.507981 1325.434063 0.962197012 -0.055595775 0.81949885 1 20.28001908 19.18684389 55669 mitofusin 1 "GO:0003924,GO:0005515,GO:0005525,GO:0005739,GO:0005741,GO:0008053,GO:0010918,GO:0016021,GO:0016236,GO:0031306,GO:0031307,GO:0042802,GO:0046039,GO:0051646,GO:0098799,GO:1990613" GTPase activity|protein binding|GTP binding|mitochondrion|mitochondrial outer membrane|mitochondrial fusion|positive regulation of mitochondrial membrane potential|integral component of membrane|macroautophagy|intrinsic component of mitochondrial outer membrane|integral component of mitochondrial outer membrane|identical protein binding|GTP metabolic process|mitochondrion localization|outer mitochondrial membrane protein complex|mitochondrial membrane fusion "hsa04137,hsa04621,hsa05012,hsa05022" Mitophagy - animal|NOD-like receptor signaling pathway|Parkinson disease|Pathways of neurodegeneration - multiple diseases MFN2 3152.229692 3283.546214 3020.91317 0.920015426 -0.120270043 0.612233928 1 36.04954259 32.61114494 9927 mitofusin 2 "GO:0003924,GO:0005515,GO:0005525,GO:0005739,GO:0005741,GO:0005829,GO:0006626,GO:0006915,GO:0006986,GO:0007006,GO:0007050,GO:0007596,GO:0008053,GO:0016021,GO:0016236,GO:0031306,GO:0031625,GO:0034497,GO:0046580,GO:0048662,GO:0051646,GO:0061734,GO:0120162,GO:1904707,GO:1905461" GTPase activity|protein binding|GTP binding|mitochondrion|mitochondrial outer membrane|cytosol|protein targeting to mitochondrion|apoptotic process|response to unfolded protein|mitochondrial membrane organization|cell cycle arrest|blood coagulation|mitochondrial fusion|integral component of membrane|macroautophagy|intrinsic component of mitochondrial outer membrane|ubiquitin protein ligase binding|protein localization to phagophore assembly site|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|mitochondrion localization|parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization|positive regulation of cold-induced thermogenesis|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of vascular associated smooth muscle cell apoptotic process "hsa04137,hsa04621,hsa05012,hsa05022" Mitophagy - animal|NOD-like receptor signaling pathway|Parkinson disease|Pathways of neurodegeneration - multiple diseases MFSD1 719.0743326 672.1073682 766.0412969 1.139760302 0.188730449 0.461404646 1 15.63606581 17.52315064 64747 major facilitator superfamily domain containing 1 "GO:0005764,GO:0016021,GO:0022857,GO:0042803,GO:0050821,GO:0055085,GO:0061462" lysosome|integral component of membrane|transmembrane transporter activity|protein homodimerization activity|protein stabilization|transmembrane transport|protein localization to lysosome MFSD10 1268.714073 1122.606579 1414.821567 1.260300441 0.333767697 0.166299397 1 28.83130408 35.72806974 10227 major facilitator superfamily domain containing 10 "GO:0005515,GO:0005637,GO:0006915,GO:0008493,GO:0008514,GO:0015904,GO:0016021,GO:0030659,GO:0031526,GO:0043252" protein binding|nuclear inner membrane|apoptotic process|tetracycline transmembrane transporter activity|organic anion transmembrane transporter activity|tetracycline transmembrane transport|integral component of membrane|cytoplasmic vesicle membrane|brush border membrane|sodium-independent organic anion transport MFSD11 391.9510277 398.4785171 385.4235384 0.967237936 -0.048057265 0.87733966 1 3.641449672 3.463209883 79157 major facilitator superfamily domain containing 11 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane MFSD12 1094.170532 1057.060505 1131.28056 1.07021363 0.097898808 0.690665375 1 19.40604621 20.42108052 126321 major facilitator superfamily domain containing 12 "GO:0005215,GO:0005765,GO:0005770,GO:0005887,GO:0008643,GO:0015293,GO:0048022,GO:0055085,GO:0071702" transporter activity|lysosomal membrane|late endosome|integral component of plasma membrane|carbohydrate transport|symporter activity|negative regulation of melanin biosynthetic process|transmembrane transport|organic substance transport MFSD13A 262.4383922 291.3158871 233.5608973 0.801744455 -0.318785623 0.335147492 1 3.896489594 3.071713204 79847 major facilitator superfamily domain containing 13A "GO:0005515,GO:0016021" protein binding|integral component of membrane MFSD14A 1256.936783 1229.769209 1284.104357 1.044183207 0.062374862 0.798760174 1 21.01521693 21.5765379 64645 major facilitator superfamily domain containing 14A "GO:0016021,GO:0022857,GO:0055085" integral component of membrane|transmembrane transporter activity|transmembrane transport MFSD14B 2703.938413 2667.621195 2740.255631 1.027228167 0.038756667 0.871273352 1 39.02577859 39.41755428 84641 major facilitator superfamily domain containing 14B "GO:0005515,GO:0016021,GO:0022857,GO:0055085" protein binding|integral component of membrane|transmembrane transporter activity|transmembrane transport MFSD14C 258.4553742 237.2143652 279.6963832 1.179087038 0.237670219 0.477446919 1 4.773640532 5.534351718 84278 "GO:0005515,GO:0016021,GO:0022857,GO:0055085" protein binding|integral component of membrane|transmembrane transporter activity|transmembrane transport MFSD2A 214.078654 245.5376763 182.6196316 0.743754011 -0.427102551 0.228493517 1 6.061005784 4.432463806 84879 major facilitator superfamily domain containing 2A "GO:0003406,GO:0005215,GO:0005324,GO:0005548,GO:0005789,GO:0005886,GO:0005887,GO:0006656,GO:0007420,GO:0008594,GO:0008643,GO:0009267,GO:0010867,GO:0015245,GO:0015293,GO:0015711,GO:0015908,GO:0015909,GO:0016021,GO:0021766,GO:0030307,GO:0031999,GO:0034379,GO:0035633,GO:0035845,GO:0040014,GO:0045056,GO:0050773,GO:0050890,GO:0051977,GO:0051978,GO:0055085,GO:0060042,GO:0060856,GO:0061744,GO:0071702,GO:0097009,GO:0140329,GO:0140348,GO:0150011,GO:0150104,GO:0150172,GO:0150175,GO:0150178,GO:1901480,GO:1990379,GO:1990403,GO:1990963" retinal pigment epithelium development|transporter activity|long-chain fatty acid transporter activity|phospholipid transporter activity|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|phosphatidylcholine biosynthetic process|brain development|photoreceptor cell morphogenesis|carbohydrate transport|cellular response to starvation|positive regulation of triglyceride biosynthetic process|fatty acid transmembrane transporter activity|symporter activity|organic anion transport|fatty acid transport|long-chain fatty acid transport|integral component of membrane|hippocampus development|positive regulation of cell growth|negative regulation of fatty acid beta-oxidation|very-low-density lipoprotein particle assembly|maintenance of blood-brain barrier|photoreceptor cell outer segment organization|regulation of multicellular organism growth|transcytosis|regulation of dendrite development|cognition|lysophospholipid transport|lysophospholipid:sodium symporter activity|transmembrane transport|retina morphogenesis in camera-type eye|establishment of blood-brain barrier|motor behavior|organic substance transport|energy homeostasis|lysophospholipid translocation|lysophosphatidylcholine flippase activity|regulation of neuron projection arborization|transport across blood-brain barrier|regulation of phosphatidylcholine metabolic process|regulation of phosphatidylethanolamine metabolic process|regulation of phosphatidylserine metabolic process|oleate transmembrane transporter activity|lipid transport across blood-brain barrier|embryonic brain development|establishment of blood-retinal barrier MFSD2B 37.46999103 37.45489978 37.48508228 1.000805836 0.001162108 1 1 0.400661287 0.394274228 388931 major facilitator superfamily domain containing 2B "GO:0005215,GO:0005887,GO:0006869,GO:0008643,GO:0015293,GO:0046624,GO:0055085,GO:0071702" transporter activity|integral component of plasma membrane|lipid transport|carbohydrate transport|symporter activity|sphingolipid transporter activity|transmembrane transport|organic substance transport MFSD3 268.4682538 235.1335375 301.8029702 1.283538594 0.360126677 0.272248114 1 4.938467036 6.232643259 113655 major facilitator superfamily domain containing 3 "GO:0005515,GO:0015295,GO:0016021,GO:1902600" protein binding|solute:proton symporter activity|integral component of membrane|proton transmembrane transport MFSD4A 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.030029733 0.040916797 148808 major facilitator superfamily domain containing 4A "GO:0005355,GO:0016021,GO:1904659" glucose transmembrane transporter activity|integral component of membrane|glucose transmembrane transport MFSD4B 264.0587637 245.5376763 282.5798511 1.15086147 0.202714186 0.543104705 1 0.881526707 0.997538586 91749 major facilitator superfamily domain containing 4B "GO:0005355,GO:0005515,GO:0006814,GO:0015293,GO:0016021,GO:0016324,GO:1904659" glucose transmembrane transporter activity|protein binding|sodium ion transport|symporter activity|integral component of membrane|apical plasma membrane|glucose transmembrane transport MFSD5 496.8157921 451.5396251 542.0919592 1.200541279 0.26368501 0.336686889 1 9.008538279 10.63414565 84975 major facilitator superfamily domain containing 5 "GO:0005515,GO:0005886,GO:0015098,GO:0015689,GO:0016020,GO:0016021" protein binding|plasma membrane|molybdate ion transmembrane transporter activity|molybdate ion transport|membrane|integral component of membrane MFSD6 771.6347409 828.1694506 715.1000313 0.863470671 -0.211780919 0.403252322 1 8.153086417 6.922146954 54842 major facilitator superfamily domain containing 6 "GO:0005515,GO:0005886,GO:0016020,GO:0016021,GO:0042590" protein binding|plasma membrane|membrane|integral component of membrane|antigen processing and presentation of exogenous peptide antigen via MHC class I MFSD8 287.507705 293.3967149 281.6186951 0.959856334 -0.059109608 0.863921577 1 2.958813952 2.792512151 256471 major facilitator superfamily domain containing 8 "GO:0005765,GO:0007040,GO:0010506,GO:0016021,GO:0022857,GO:0038202,GO:0048666,GO:0055085,GO:0097352,GO:1905165" lysosomal membrane|lysosome organization|regulation of autophagy|integral component of membrane|transmembrane transporter activity|TORC1 signaling|neuron development|transmembrane transport|autophagosome maturation|regulation of lysosomal protein catabolic process hsa04142 Lysosome MFSD9 295.469325 313.1645787 277.7740713 0.886990708 -0.173009104 0.589814568 1 3.023339 2.636799423 84804 major facilitator superfamily domain containing 9 "GO:0016021,GO:0022857,GO:0055085" integral component of membrane|transmembrane transporter activity|transmembrane transport MGA 1197.007346 1372.305911 1021.708781 0.744519697 -0.425618078 0.078794247 1 6.097530954 4.463765633 23269 MAX dimerization protein MGA "GO:0000785,GO:0000978,GO:0000981,GO:0001708,GO:0005515,GO:0005654,GO:0006357,GO:0046983,GO:0070317,GO:0071339" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cell fate specification|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|protein dimerization activity|negative regulation of G0 to G1 transition|MLL1 complex" MGAM 61.08750904 64.50566072 57.66935736 0.894020102 -0.161620825 0.796618999 1 0.361688228 0.317945613 8972 maltase-glucoamylase "GO:0000023,GO:0003824,GO:0004339,GO:0004553,GO:0004558,GO:0005515,GO:0005886,GO:0005983,GO:0016021,GO:0016324,GO:0030246,GO:0032450,GO:0043312,GO:0044245,GO:0070062,GO:0070821,GO:0101003" "maltose metabolic process|catalytic activity|glucan 1,4-alpha-glucosidase activity|hydrolase activity, hydrolyzing O-glycosyl compounds|alpha-1,4-glucosidase activity|protein binding|plasma membrane|starch catabolic process|integral component of membrane|apical plasma membrane|carbohydrate binding|maltose alpha-glucosidase activity|neutrophil degranulation|polysaccharide digestion|extracellular exosome|tertiary granule membrane|ficolin-1-rich granule membrane" "hsa00052,hsa00500,hsa04973" Galactose metabolism|Starch and sucrose metabolism|Carbohydrate digestion and absorption MGARP 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.045363543 0.12361954 84709 mitochondria localized glutamic acid rich protein "GO:0005515,GO:0005739,GO:0006626,GO:0008089,GO:0008090,GO:0010822,GO:0019896,GO:0031307,GO:0071383,GO:0071456,GO:0097211,GO:1904115" protein binding|mitochondrion|protein targeting to mitochondrion|anterograde axonal transport|retrograde axonal transport|positive regulation of mitochondrion organization|axonal transport of mitochondrion|integral component of mitochondrial outer membrane|cellular response to steroid hormone stimulus|cellular response to hypoxia|cellular response to gonadotropin-releasing hormone|axon cytoplasm MGAT1 1822.802319 1664.662212 1980.942425 1.189996632 0.25095749 0.289882619 1 8.212994615 9.609890712 4245 "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase" "GO:0000139,GO:0001701,GO:0003827,GO:0005515,GO:0005794,GO:0006049,GO:0006486,GO:0006487,GO:0016020,GO:0016021,GO:0018215,GO:0018279,GO:0030145,GO:0048471,GO:0070062,GO:1903561" "Golgi membrane|in utero embryonic development|alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|protein binding|Golgi apparatus|UDP-N-acetylglucosamine catabolic process|protein glycosylation|protein N-linked glycosylation|membrane|integral component of membrane|protein phosphopantetheinylation|protein N-linked glycosylation via asparagine|manganese ion binding|perinuclear region of cytoplasm|extracellular exosome|extracellular vesicle" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis MGAT2 938.3991009 1017.524777 859.2734247 0.844474202 -0.243874744 0.324528151 1 20.23981634 16.80599124 4247 "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase" "GO:0000139,GO:0005794,GO:0005795,GO:0006487,GO:0008455,GO:0009312,GO:0016020,GO:0016021,GO:0018215,GO:0018279,GO:0030145,GO:0030246,GO:0042803" "Golgi membrane|Golgi apparatus|Golgi stack|protein N-linked glycosylation|alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|oligosaccharide biosynthetic process|membrane|integral component of membrane|protein phosphopantetheinylation|protein N-linked glycosylation via asparagine|manganese ion binding|carbohydrate binding|protein homodimerization activity" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis MGAT4A 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.037567643 0.04550002 11320 "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A" "GO:0000139,GO:0005783,GO:0005788,GO:0005793,GO:0005795,GO:0006487,GO:0006491,GO:0008375,GO:0008454,GO:0016021,GO:0018215,GO:0043687,GO:0044267,GO:0046872,GO:0070062" "Golgi membrane|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|Golgi stack|protein N-linked glycosylation|N-glycan processing|acetylglucosaminyltransferase activity|alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|integral component of membrane|protein phosphopantetheinylation|post-translational protein modification|cellular protein metabolic process|metal ion binding|extracellular exosome" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis MGAT4B 4476.993365 4351.010857 4602.975873 1.057909535 0.081216264 0.734585023 1 89.13836953 92.72234274 11282 "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B" "GO:0000139,GO:0005515,GO:0005783,GO:0005793,GO:0005795,GO:0006487,GO:0006491,GO:0008375,GO:0008454,GO:0016021,GO:0018215,GO:0046872" "Golgi membrane|protein binding|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi stack|protein N-linked glycosylation|N-glycan processing|acetylglucosaminyltransferase activity|alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|integral component of membrane|protein phosphopantetheinylation|metal ion binding" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis MGAT4C 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.005514023 25834 MGAT4 family member C "GO:0000139,GO:0006487,GO:0008375,GO:0008454,GO:0016021,GO:0018215,GO:0046872" "Golgi membrane|protein N-linked glycosylation|acetylglucosaminyltransferase activity|alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|integral component of membrane|protein phosphopantetheinylation|metal ion binding" "hsa00510,hsa00513" N-Glycan biosynthesis|Various types of N-glycan biosynthesis MGAT5 2399.869603 2128.686804 2671.052402 1.254788819 0.32744458 0.166038313 1 11.20798169 13.82831397 4249 "alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase" "GO:0000139,GO:0004864,GO:0005794,GO:0006487,GO:0016020,GO:0016021,GO:0018215,GO:0018279,GO:0030144,GO:0030145,GO:0030335,GO:0070062,GO:1903614,GO:1904894" "Golgi membrane|protein phosphatase inhibitor activity|Golgi apparatus|protein N-linked glycosylation|membrane|integral component of membrane|protein phosphopantetheinylation|protein N-linked glycosylation via asparagine|alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity|manganese ion binding|positive regulation of cell migration|extracellular exosome|negative regulation of protein tyrosine phosphatase activity|positive regulation of receptor signaling pathway via STAT" hsa00510 N-Glycan biosynthesis MGAT5B 113.6485318 119.6475965 107.6494671 0.899721099 -0.152450239 0.748527686 1 0.797175071 0.705233271 146664 "alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B" "GO:0000139,GO:0005515,GO:0005794,GO:0006487,GO:0016021,GO:0018215,GO:0018242,GO:0030144,GO:0030145" "Golgi membrane|protein binding|Golgi apparatus|protein N-linked glycosylation|integral component of membrane|protein phosphopantetheinylation|protein O-linked glycosylation via serine|alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity|manganese ion binding" "hsa00510,hsa00515" N-Glycan biosynthesis|Mannose type O-glycan biosynthesis MGLL 4394.542159 4331.242993 4457.841324 1.029229099 0.041564152 0.862695225 1 42.91691015 43.43218533 11343 monoglyceride lipase "GO:0004622,GO:0005515,GO:0005654,GO:0005789,GO:0005829,GO:0005886,GO:0006629,GO:0006633,GO:0006954,GO:0009966,GO:0016020,GO:0016298,GO:0019369,GO:0019433,GO:0019898,GO:0036155,GO:0042803,GO:0046464,GO:0047372,GO:0050727,GO:0051930,GO:0052651,GO:2000124" lysophospholipase activity|protein binding|nucleoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|lipid metabolic process|fatty acid biosynthetic process|inflammatory response|regulation of signal transduction|membrane|lipase activity|arachidonic acid metabolic process|triglyceride catabolic process|extrinsic component of membrane|acylglycerol acyl-chain remodeling|protein homodimerization activity|acylglycerol catabolic process|acylglycerol lipase activity|regulation of inflammatory response|regulation of sensory perception of pain|monoacylglycerol catabolic process|regulation of endocannabinoid signaling pathway "hsa00561,hsa04714,hsa04723,hsa04923" Glycerolipid metabolism|Thermogenesis|Retrograde endocannabinoid signaling|Regulation of lipolysis in adipocytes MGME1 1175.496422 1186.071826 1164.921019 0.982167347 -0.025959235 0.918365183 1 20.06926869 19.38153713 92667 mitochondrial genome maintenance exonuclease 1 "GO:0000002,GO:0005515,GO:0005739,GO:0006264,GO:0008297,GO:0043504,GO:0090305" mitochondrial genome maintenance|protein binding|mitochondrion|mitochondrial DNA replication|single-stranded DNA exodeoxyribonuclease activity|mitochondrial DNA repair|nucleic acid phosphodiester bond hydrolysis MGMT 251.4398189 254.9014012 247.9782366 0.972839833 -0.039725793 0.917766181 1 2.778517013 2.657820112 4255 O-6-methylguanine-DNA methyltransferase "GO:0003677,GO:0003908,GO:0005634,GO:0005654,GO:0006266,GO:0006281,GO:0006306,GO:0006307,GO:0008168,GO:0009008,GO:0016020,GO:0043066,GO:0046872,GO:2000781" DNA binding|methylated-DNA-[protein]-cysteine S-methyltransferase activity|nucleus|nucleoplasm|DNA ligation|DNA repair|DNA methylation|DNA dealkylation involved in DNA repair|methyltransferase activity|DNA-methyltransferase activity|membrane|negative regulation of apoptotic process|metal ion binding|positive regulation of double-strand break repair MGRN1 411.4811177 431.7717613 391.1904741 0.906012179 -0.142397652 0.624686593 1 3.563146024 3.174233238 23295 mahogunin ring finger 1 "GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005769,GO:0005783,GO:0005829,GO:0005886,GO:0006513,GO:0008333,GO:0016020,GO:0016567,GO:0043231,GO:0043951,GO:0045744,GO:0045879,GO:0046872,GO:0061630,GO:0070062" ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|early endosome|endoplasmic reticulum|cytosol|plasma membrane|protein monoubiquitination|endosome to lysosome transport|membrane|protein ubiquitination|intracellular membrane-bounded organelle|negative regulation of cAMP-mediated signaling|negative regulation of G protein-coupled receptor signaling pathway|negative regulation of smoothened signaling pathway|metal ion binding|ubiquitin protein ligase activity|extracellular exosome "hsa04120,hsa04340" Ubiquitin mediated proteolysis|Hedgehog signaling pathway MGST1 2195.964303 2377.345722 2014.582884 0.847408463 -0.238870558 0.312414431 1 56.51428588 47.08929838 4257 microsomal glutathione S-transferase 1 "GO:0004364,GO:0004602,GO:0005515,GO:0005634,GO:0005739,GO:0005741,GO:0005778,GO:0005783,GO:0005789,GO:0005886,GO:0006805,GO:0010243,GO:0016021,GO:0032496,GO:0033327,GO:0035577,GO:0042493,GO:0042802,GO:0043295,GO:0043312,GO:0045177,GO:0055114,GO:0071449,GO:0098869,GO:1901687" glutathione transferase activity|glutathione peroxidase activity|protein binding|nucleus|mitochondrion|mitochondrial outer membrane|peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|xenobiotic metabolic process|response to organonitrogen compound|integral component of membrane|response to lipopolysaccharide|Leydig cell differentiation|azurophil granule membrane|response to drug|identical protein binding|glutathione binding|neutrophil degranulation|apical part of cell|oxidation-reduction process|cellular response to lipid hydroperoxide|cellular oxidant detoxification|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis MGST2 383.8805817 350.6194785 417.1416849 1.189727641 0.250631341 0.393816972 1 5.171895288 6.050182201 4258 microsomal glutathione S-transferase 2 "GO:0004364,GO:0004464,GO:0004602,GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0005886,GO:0006629,GO:0006750,GO:0006805,GO:0008047,GO:0010243,GO:0016020,GO:0016021,GO:0019370,GO:0032496,GO:0042802,GO:0043231,GO:0043295,GO:0046466,GO:0050729,GO:0050790,GO:0055114,GO:0098869,GO:1901687" glutathione transferase activity|leukotriene-C4 synthase activity|glutathione peroxidase activity|protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|lipid metabolic process|glutathione biosynthetic process|xenobiotic metabolic process|enzyme activator activity|response to organonitrogen compound|membrane|integral component of membrane|leukotriene biosynthetic process|response to lipopolysaccharide|identical protein binding|intracellular membrane-bounded organelle|glutathione binding|membrane lipid catabolic process|positive regulation of inflammatory response|regulation of catalytic activity|oxidation-reduction process|cellular oxidant detoxification|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis MGST3 1783.687419 1634.49021 1932.884628 1.182561153 0.241914791 0.307908361 1 130.9755832 152.2948186 4259 microsomal glutathione S-transferase 3 "GO:0004364,GO:0004464,GO:0004602,GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0006629,GO:0006805,GO:0016020,GO:0016021,GO:0019370,GO:0042802,GO:0043231,GO:0055114,GO:0098869,GO:1901687" glutathione transferase activity|leukotriene-C4 synthase activity|glutathione peroxidase activity|protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|lipid metabolic process|xenobiotic metabolic process|membrane|integral component of membrane|leukotriene biosynthetic process|identical protein binding|intracellular membrane-bounded organelle|oxidation-reduction process|cellular oxidant detoxification|glutathione derivative biosynthetic process "hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis MIA2 434.8803692 503.5603192 366.2004192 0.72722255 -0.45953116 0.103971482 1 3.203109503 2.290394549 4253 MIA SH3 domain ER export factor 2 "GO:0005515,GO:0005783,GO:0005789,GO:0006888,GO:0009306,GO:0016020,GO:0016021,GO:0035459,GO:0070971" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|protein secretion|membrane|integral component of membrane|vesicle cargo loading|endoplasmic reticulum exit site MIA3 1263.733458 1357.740117 1169.726798 0.861524812 -0.215035749 0.373066025 1 7.803154708 6.610117592 375056 MIA SH3 domain ER export factor 3 "GO:0000139,GO:0002042,GO:0002687,GO:0005515,GO:0005788,GO:0005789,GO:0006887,GO:0006888,GO:0006897,GO:0007029,GO:0007162,GO:0009306,GO:0015031,GO:0016020,GO:0016021,GO:0030336,GO:0035459,GO:0038024,GO:0042060,GO:0042953,GO:0043231,GO:0043687,GO:0044267,GO:0070971,GO:0070973,GO:0090110,GO:0140052,GO:1903038,GO:2000402" Golgi membrane|cell migration involved in sprouting angiogenesis|positive regulation of leukocyte migration|protein binding|endoplasmic reticulum lumen|endoplasmic reticulum membrane|exocytosis|endoplasmic reticulum to Golgi vesicle-mediated transport|endocytosis|endoplasmic reticulum organization|negative regulation of cell adhesion|protein secretion|protein transport|membrane|integral component of membrane|negative regulation of cell migration|vesicle cargo loading|cargo receptor activity|wound healing|lipoprotein transport|intracellular membrane-bounded organelle|post-translational protein modification|cellular protein metabolic process|endoplasmic reticulum exit site|protein localization to endoplasmic reticulum exit site|COPII-coated vesicle cargo loading|cellular response to oxidised low-density lipoprotein particle stimulus|negative regulation of leukocyte cell-cell adhesion|negative regulation of lymphocyte migration MIB1 1452.75286 1576.227032 1329.278687 0.843329457 -0.245831747 0.303930421 1 8.918611082 7.395468212 57534 MIB E3 ubiquitin protein ligase 1 "GO:0001568,GO:0001701,GO:0001756,GO:0001841,GO:0001947,GO:0004842,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0006511,GO:0006897,GO:0007219,GO:0008270,GO:0014069,GO:0016567,GO:0031410,GO:0045665,GO:0045807" blood vessel development|in utero embryonic development|somitogenesis|neural tube formation|heart looping|ubiquitin-protein transferase activity|protein binding|cytoplasm|centrosome|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|endocytosis|Notch signaling pathway|zinc ion binding|postsynaptic density|protein ubiquitination|cytoplasmic vesicle|negative regulation of neuron differentiation|positive regulation of endocytosis MIB2 343.4428344 323.5687175 363.3169514 1.122843253 0.167156544 0.585114647 1 1.829071895 2.019394127 142678 MIB E3 ubiquitin protein ligase 2 "GO:0000151,GO:0000209,GO:0003779,GO:0004842,GO:0005515,GO:0005737,GO:0005769,GO:0005829,GO:0007219,GO:0008270,GO:0016567,GO:0043123,GO:0061630" ubiquitin ligase complex|protein polyubiquitination|actin binding|ubiquitin-protein transferase activity|protein binding|cytoplasm|early endosome|cytosol|Notch signaling pathway|zinc ion binding|protein ubiquitination|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin protein ligase activity MICA 468.8284129 435.9334168 501.723409 1.150917525 0.202784453 0.467719259 1 16.3492377 18.50175346 100507436 MHC class I polypeptide-related sequence A "GO:0001913,GO:0002418,GO:0005515,GO:0005615,GO:0005737,GO:0005886,GO:0005887,GO:0006955,GO:0006974,GO:0009408,GO:0009897,GO:0009986,GO:0016032,GO:0019835,GO:0030881,GO:0032815,GO:0042267,GO:0042742,GO:0045953,GO:0046629,GO:0046703,GO:0050776,GO:0051607" T cell mediated cytotoxicity|immune response to tumor cell|protein binding|extracellular space|cytoplasm|plasma membrane|integral component of plasma membrane|immune response|cellular response to DNA damage stimulus|response to heat|external side of plasma membrane|cell surface|viral process|cytolysis|beta-2-microglobulin binding|negative regulation of natural killer cell activation|natural killer cell mediated cytotoxicity|defense response to bacterium|negative regulation of natural killer cell mediated cytotoxicity|gamma-delta T cell activation|natural killer cell lectin-like receptor binding|regulation of immune response|defense response to virus "hsa04650,hsa05167" Natural killer cell mediated cytotoxicity|Kaposi sarcoma-associated herpesvirus infection MICAL1 1335.161553 1302.598181 1367.724925 1.04999757 0.07038599 0.771994765 1 18.61238845 19.21593764 64780 "microtubule associated monooxygenase, calponin and LIM domain containing 1" "GO:0001933,GO:0003779,GO:0005515,GO:0005737,GO:0005829,GO:0005882,GO:0005886,GO:0007010,GO:0007165,GO:0007596,GO:0015629,GO:0016174,GO:0016709,GO:0017124,GO:0019417,GO:0019901,GO:0030042,GO:0030496,GO:0031267,GO:0043154,GO:0045171,GO:0046872,GO:0051015,GO:0051017,GO:0055114,GO:0071949,GO:1903305,GO:1990026" "negative regulation of protein phosphorylation|actin binding|protein binding|cytoplasm|cytosol|intermediate filament|plasma membrane|cytoskeleton organization|signal transduction|blood coagulation|actin cytoskeleton|NAD(P)H oxidase H2O2-forming activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|SH3 domain binding|sulfur oxidation|protein kinase binding|actin filament depolymerization|midbody|small GTPase binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|intercellular bridge|metal ion binding|actin filament binding|actin filament bundle assembly|oxidation-reduction process|FAD binding|regulation of regulated secretory pathway|hippocampal mossy fiber expansion" MICAL2 6962.776487 7448.322986 6477.229987 0.869622598 -0.201538664 0.409488531 1 52.25493734 44.6816628 9645 "microtubule associated monooxygenase, calponin and LIM domain containing 2" "GO:0001947,GO:0003779,GO:0005515,GO:0005634,GO:0007010,GO:0007507,GO:0010735,GO:0016491,GO:0016709,GO:0019417,GO:0030042,GO:0043914,GO:0046872,GO:0055114,GO:0071949" "heart looping|actin binding|protein binding|nucleus|cytoskeleton organization|heart development|positive regulation of transcription via serum response element binding|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|sulfur oxidation|actin filament depolymerization|NADPH:sulfur oxidoreductase activity|metal ion binding|oxidation-reduction process|FAD binding" MICAL3 2401.521501 2601.034707 2202.008295 0.846589355 -0.240265746 0.309482213 1 9.393181878 7.819099031 57553 "microtubule associated monooxygenase, calponin and LIM domain containing 3" "GO:0003779,GO:0005634,GO:0005654,GO:0005819,GO:0005829,GO:0005886,GO:0005938,GO:0006887,GO:0007010,GO:0007049,GO:0016709,GO:0030042,GO:0042995,GO:0045171,GO:0046872,GO:0051301,GO:0055114,GO:0071949,GO:0090543" "actin binding|nucleus|nucleoplasm|spindle|cytosol|plasma membrane|cell cortex|exocytosis|cytoskeleton organization|cell cycle|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|actin filament depolymerization|cell projection|intercellular bridge|metal ion binding|cell division|oxidation-reduction process|FAD binding|Flemming body" MICALCL 108.882381 120.6880104 97.07675156 0.804361189 -0.314084622 0.496781988 1 1.066373725 0.843396359 84953 MICAL C-terminal like "GO:0005737,GO:0005815,GO:0007275,GO:0007283,GO:0008150,GO:0030036,GO:0030154,GO:0031941,GO:0051019" cytoplasm|microtubule organizing center|multicellular organism development|spermatogenesis|biological_process|actin cytoskeleton organization|cell differentiation|filamentous actin|mitogen-activated protein kinase binding MICALL1 1209.502988 1271.385765 1147.620211 0.902653029 -0.147756558 0.542820639 1 13.5838882 12.0563576 85377 MICAL like 1 "GO:0005515,GO:0005769,GO:0005770,GO:0005802,GO:0006612,GO:0006897,GO:0006898,GO:0019898,GO:0031175,GO:0031267,GO:0031902,GO:0032458,GO:0036010,GO:0042802,GO:0045296,GO:0046872,GO:0055038,GO:0070300,GO:0097320,GO:1990126" "protein binding|early endosome|late endosome|trans-Golgi network|protein targeting to membrane|endocytosis|receptor-mediated endocytosis|extrinsic component of membrane|neuron projection development|small GTPase binding|late endosome membrane|slow endocytic recycling|protein localization to endosome|identical protein binding|cadherin binding|metal ion binding|recycling endosome membrane|phosphatidic acid binding|plasma membrane tubulation|retrograde transport, endosome to plasma membrane" MICALL2 176.4551775 191.4361544 161.4742006 0.843488531 -0.245559643 0.525908914 1 2.42214218 2.008861488 79778 MICAL like 2 "GO:0001725,GO:0005515,GO:0005829,GO:0005886,GO:0005911,GO:0005923,GO:0030041,GO:0031005,GO:0031175,GO:0031267,GO:0031532,GO:0032432,GO:0032456,GO:0034446,GO:0042805,GO:0043005,GO:0046872,GO:0051015,GO:0055037,GO:0070830,GO:1903955" stress fiber|protein binding|cytosol|plasma membrane|cell-cell junction|bicellular tight junction|actin filament polymerization|filamin binding|neuron projection development|small GTPase binding|actin cytoskeleton reorganization|actin filament bundle|endocytic recycling|substrate adhesion-dependent cell spreading|actinin binding|neuron projection|metal ion binding|actin filament binding|recycling endosome|bicellular tight junction assembly|positive regulation of protein targeting to mitochondrion hsa04530 Tight junction MICB 616.7904812 674.188196 559.3927664 0.829727915 -0.26928977 0.303970289 1 14.42669804 11.76992843 4277 MHC class I polypeptide-related sequence B "GO:0002250,GO:0002429,GO:0005615,GO:0005886,GO:0006955,GO:0006979,GO:0009408,GO:0009897,GO:0009986,GO:0016021,GO:0016032,GO:0019835,GO:0032526,GO:0046629,GO:0046703,GO:0050689,GO:0050776" adaptive immune response|immune response-activating cell surface receptor signaling pathway|extracellular space|plasma membrane|immune response|response to oxidative stress|response to heat|external side of plasma membrane|cell surface|integral component of membrane|viral process|cytolysis|response to retinoic acid|gamma-delta T cell activation|natural killer cell lectin-like receptor binding|negative regulation of defense response to virus by host|regulation of immune response "hsa04650,hsa05167" Natural killer cell mediated cytotoxicity|Kaposi sarcoma-associated herpesvirus infection MICOS10 218.1862037 189.3553266 247.0170807 1.304516145 0.383514799 0.277197823 1 2.549330414 3.269992557 440574 mitochondrial contact site and cristae organizing system subunit 10 "GO:0001401,GO:0003674,GO:0005515,GO:0005739,GO:0007007,GO:0008150,GO:0061617,GO:0140275" SAM complex|molecular_function|protein binding|mitochondrion|inner mitochondrial membrane organization|biological_process|MICOS complex|MIB complex MICOS10-NBL1 5.885822626 3.121241648 8.650403604 2.771462315 1.470647391 0.36367629 1 0.075578462 0.205957782 100532736 MICOS10-NBL1 readthrough hsa04350 TGF-beta signaling pathway MICOS13 291.1246159 262.1842984 320.0649333 1.220763163 0.287783334 0.367288159 1 13.99229413 16.7954452 125988 mitochondrial contact site and cristae organizing system subunit 13 "GO:0001401,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0007007,GO:0042407,GO:0044284,GO:0061617,GO:0140275" SAM complex|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|inner mitochondrial membrane organization|cristae formation|mitochondrial crista junction|MICOS complex|MIB complex MICU1 3059.68316 2973.502877 3145.863444 1.057965495 0.081292576 0.73227893 1 58.19229316 60.53522403 10367 mitochondrial calcium uptake 1 "GO:0005509,GO:0005515,GO:0005622,GO:0005739,GO:0005743,GO:0005758,GO:0006851,GO:0006952,GO:0032592,GO:0034704,GO:0036444,GO:0042802,GO:0046982,GO:0051260,GO:0051560,GO:0051561,GO:0070509,GO:1900069,GO:1990246" calcium ion binding|protein binding|intracellular anatomical structure|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial calcium ion transmembrane transport|defense response|integral component of mitochondrial membrane|calcium channel complex|calcium import into the mitochondrion|identical protein binding|protein heterodimerization activity|protein homooligomerization|mitochondrial calcium ion homeostasis|positive regulation of mitochondrial calcium ion concentration|calcium ion import|regulation of cellular hyperosmotic salinity response|uniplex complex MICU2 1232.958189 1104.919543 1360.996834 1.231761029 0.300722389 0.213403144 1 29.99365477 36.32679027 221154 mitochondrial calcium uptake 2 "GO:0005509,GO:0005515,GO:0005739,GO:0005743,GO:0005758,GO:0006851,GO:0034704,GO:0036444,GO:0046982,GO:0051560,GO:0051561,GO:0051562,GO:1990246" calcium ion binding|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial calcium ion transmembrane transport|calcium channel complex|calcium import into the mitochondrion|protein heterodimerization activity|mitochondrial calcium ion homeostasis|positive regulation of mitochondrial calcium ion concentration|negative regulation of mitochondrial calcium ion concentration|uniplex complex MID1 974.7890491 1051.858435 897.7196629 0.853460535 -0.228603652 0.35412689 1 7.095014088 5.953987031 4281 midline 1 "GO:0000226,GO:0005515,GO:0005819,GO:0005829,GO:0005874,GO:0005875,GO:0005881,GO:0007389,GO:0008017,GO:0008270,GO:0016740,GO:0019899,GO:0031625,GO:0032874,GO:0035372,GO:0042802,GO:0042803,GO:0051219,GO:0060333" microtubule cytoskeleton organization|protein binding|spindle|cytosol|microtubule|microtubule associated complex|cytoplasmic microtubule|pattern specification process|microtubule binding|zinc ion binding|transferase activity|enzyme binding|ubiquitin protein ligase binding|positive regulation of stress-activated MAPK cascade|protein localization to microtubule|identical protein binding|protein homodimerization activity|phosphoprotein binding|interferon-gamma-mediated signaling pathway hsa04120 Ubiquitin mediated proteolysis MID1IP1 1440.159067 1523.165924 1357.15221 0.891007466 -0.166490575 0.48717618 1 21.63080519 18.95069786 58526 MID1 interacting protein 1 "GO:0005515,GO:0005634,GO:0005829,GO:0005874,GO:0006629,GO:0006853,GO:0007026,GO:0008022,GO:0015630,GO:0042802,GO:0045723,GO:0046890,GO:0051258,GO:0051351" protein binding|nucleus|cytosol|microtubule|lipid metabolic process|carnitine shuttle|negative regulation of microtubule depolymerization|protein C-terminus binding|microtubule cytoskeleton|identical protein binding|positive regulation of fatty acid biosynthetic process|regulation of lipid biosynthetic process|protein polymerization|positive regulation of ligase activity MID2 778.175363 697.0773014 859.2734247 1.232680254 0.301798626 0.232308136 1 5.089852839 6.1691715 11043 midline 2 "GO:0003713,GO:0005737,GO:0005874,GO:0008017,GO:0008270,GO:0010508,GO:0016567,GO:0016740,GO:0019899,GO:0032897,GO:0035372,GO:0042803,GO:0043123,GO:0045087,GO:0045893,GO:0046597,GO:0051091,GO:0051092,GO:0051219,GO:0070062,GO:1902187" "transcription coactivator activity|cytoplasm|microtubule|microtubule binding|zinc ion binding|positive regulation of autophagy|protein ubiquitination|transferase activity|enzyme binding|negative regulation of viral transcription|protein localization to microtubule|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of transcription, DNA-templated|negative regulation of viral entry into host cell|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|phosphoprotein binding|extracellular exosome|negative regulation of viral release from host cell" MIDEAS 1090.413999 1236.011693 944.8163047 0.764407255 -0.387586624 0.112081877 1 7.759519155 5.832178242 91748 mitotic deacetylase associated SANT domain protein "GO:0000118,GO:0003677,GO:0003714,GO:0005654,GO:0005667,GO:0006357,GO:0016575,GO:0045892" "histone deacetylase complex|DNA binding|transcription corepressor activity|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|histone deacetylation|negative regulation of transcription, DNA-templated" MIDN 531.6646268 533.7323218 529.5969318 0.99225194 -0.011221617 0.974588727 1 7.257149823 7.08042333 90007 midnolin "GO:0003674,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0008150,GO:0019900,GO:0033132,GO:0046676" molecular_function|protein binding|nucleus|nucleolus|cytoplasm|cytosol|biological_process|kinase binding|negative regulation of glucokinase activity|negative regulation of insulin secretion MIEF1 487.4860513 547.2577023 427.7144004 0.781559398 -0.355572573 0.19595542 1 4.703839226 3.614811355 54471 mitochondrial elongation factor 1 "GO:0000266,GO:0005515,GO:0005739,GO:0005741,GO:0005777,GO:0008053,GO:0016021,GO:0019003,GO:0042802,GO:0043531,GO:0090141,GO:0090314" mitochondrial fission|protein binding|mitochondrion|mitochondrial outer membrane|peroxisome|mitochondrial fusion|integral component of membrane|GDP binding|identical protein binding|ADP binding|positive regulation of mitochondrial fission|positive regulation of protein targeting to membrane MIEF2 353.4506836 333.9728563 372.9285109 1.116643176 0.159168245 0.600381213 1 5.060623943 5.556350845 125170 mitochondrial elongation factor 2 "GO:0003374,GO:0005515,GO:0005739,GO:0005741,GO:0005777,GO:0007005,GO:0008053,GO:0010821,GO:0016021,GO:0090141,GO:0090314" dynamin family protein polymerization involved in mitochondrial fission|protein binding|mitochondrion|mitochondrial outer membrane|peroxisome|mitochondrion organization|mitochondrial fusion|regulation of mitochondrion organization|integral component of membrane|positive regulation of mitochondrial fission|positive regulation of protein targeting to membrane MIEN1 660.6966843 640.8949517 680.4984168 1.061794004 0.086503899 0.742463065 1 23.17302551 24.19324853 84299 migration and invasion enhancer 1 "GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006915,GO:0010269,GO:0030335,GO:0031235,GO:0034451,GO:0043066,GO:0051491" protein binding|nucleoplasm|cytosol|plasma membrane|apoptotic process|response to selenium ion|positive regulation of cell migration|intrinsic component of the cytoplasmic side of the plasma membrane|centriolar satellite|negative regulation of apoptotic process|positive regulation of filopodium assembly MIER1 1055.495967 1126.768235 984.2236989 0.873492586 -0.195132638 0.426034857 1 9.750859378 8.374777833 57708 MIER1 transcriptional regulator "GO:0000122,GO:0001103,GO:0003714,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0016575,GO:0017053,GO:0031937,GO:0032991,GO:0042826,GO:0043123" negative regulation of transcription by RNA polymerase II|RNA polymerase II repressing transcription factor binding|transcription corepressor activity|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|histone deacetylation|transcription repressor complex|positive regulation of chromatin silencing|protein-containing complex|histone deacetylase binding|positive regulation of I-kappaB kinase/NF-kappaB signaling MIER2 418.0462775 339.1749257 496.9176292 1.465077727 0.550977206 0.053908012 1 2.599991728 3.745448335 54531 MIER family member 2 "GO:0000122,GO:0001103,GO:0003714,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0016575,GO:0032991,GO:0042826" negative regulation of transcription by RNA polymerase II|RNA polymerase II repressing transcription factor binding|transcription corepressor activity|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|histone deacetylation|protein-containing complex|histone deacetylase binding MIER3 779.0415554 833.37152 724.7115908 0.86961406 -0.201552829 0.425949887 1 8.344372674 7.134958041 166968 MIER family member 3 "GO:0000122,GO:0001103,GO:0003714,GO:0004407,GO:0005634,GO:0005654,GO:0016575,GO:0032991,GO:0042826" negative regulation of transcription by RNA polymerase II|RNA polymerase II repressing transcription factor binding|transcription corepressor activity|histone deacetylase activity|nucleus|nucleoplasm|histone deacetylation|protein-containing complex|histone deacetylase binding MIF 5753.577781 5024.158639 6482.996923 1.290364694 0.36777887 0.12822665 1 481.3826078 610.7648646 4282 macrophage migration inhibitory factor "GO:0001516,GO:0001819,GO:0004167,GO:0005125,GO:0005126,GO:0005515,GO:0005576,GO:0005615,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006954,GO:0007166,GO:0009986,GO:0010629,GO:0010739,GO:0010760,GO:0019752,GO:0030336,GO:0030890,GO:0031982,GO:0032760,GO:0033138,GO:0034774,GO:0035722,GO:0042056,GO:0042327,GO:0042802,GO:0043030,GO:0043066,GO:0043312,GO:0043518,GO:0045087,GO:0048146,GO:0050178,GO:0050731,GO:0050900,GO:0050918,GO:0070062,GO:0070207,GO:0070374,GO:0071157,GO:0090344,GO:1902166,GO:1904813" "prostaglandin biosynthetic process|positive regulation of cytokine production|dopachrome isomerase activity|cytokine activity|cytokine receptor binding|protein binding|extracellular region|extracellular space|nucleoplasm|cytoplasm|cytosol|plasma membrane|inflammatory response|cell surface receptor signaling pathway|cell surface|negative regulation of gene expression|positive regulation of protein kinase A signaling|negative regulation of macrophage chemotaxis|carboxylic acid metabolic process|negative regulation of cell migration|positive regulation of B cell proliferation|vesicle|positive regulation of tumor necrosis factor production|positive regulation of peptidyl-serine phosphorylation|secretory granule lumen|interleukin-12-mediated signaling pathway|chemoattractant activity|positive regulation of phosphorylation|identical protein binding|regulation of macrophage activation|negative regulation of apoptotic process|neutrophil degranulation|negative regulation of DNA damage response, signal transduction by p53 class mediator|innate immune response|positive regulation of fibroblast proliferation|phenylpyruvate tautomerase activity|positive regulation of peptidyl-tyrosine phosphorylation|leukocyte migration|positive chemotaxis|extracellular exosome|protein homotrimerization|positive regulation of ERK1 and ERK2 cascade|negative regulation of cell cycle arrest|negative regulation of cell aging|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|ficolin-1-rich granule lumen" "hsa00350,hsa00360" Tyrosine metabolism|Phenylalanine metabolism MIF4GD 395.2754446 397.4381032 393.112786 0.989117004 -0.015786905 0.966252015 1 8.3276565 8.099191164 57409 MIF4G domain containing "GO:0003723,GO:0005515,GO:0005730,GO:0005794,GO:0005829,GO:0006446,GO:0008022,GO:0008494,GO:0042802,GO:0045727" RNA binding|protein binding|nucleolus|Golgi apparatus|cytosol|regulation of translational initiation|protein C-terminus binding|translation activator activity|identical protein binding|positive regulation of translation MIGA1 576.8288959 558.702255 594.9555368 1.064888376 0.090702211 0.737162282 1 4.536271489 4.749788847 374986 mitoguardin 1 "GO:0005515,GO:0005739,GO:0005741,GO:0005887,GO:0008053,GO:0042803,GO:0046982" protein binding|mitochondrion|mitochondrial outer membrane|integral component of plasma membrane|mitochondrial fusion|protein homodimerization activity|protein heterodimerization activity MIGA2 315.212651 314.2049926 316.2203095 1.00641402 0.009223924 0.987929779 1 4.514955027 4.467877789 84895 mitoguardin 2 "GO:0005515,GO:0005741,GO:0005887,GO:0008053,GO:0042803,GO:0046982,GO:0060348" protein binding|mitochondrial outer membrane|integral component of plasma membrane|mitochondrial fusion|protein homodimerization activity|protein heterodimerization activity|bone development MIIP 398.5501717 420.3272086 376.7731347 0.896380551 -0.157816749 0.590193519 1 11.61682579 10.23884763 60672 migration and invasion inhibitory protein "GO:0005515,GO:0010972,GO:0030336" protein binding|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of cell migration MILR1 56.32135823 65.54607461 47.09664184 0.718527267 -0.476885189 0.413851561 1 1.045761893 0.738834632 284021 mast cell immunoglobulin like receptor 1 "GO:0004888,GO:0005515,GO:0005887,GO:0007166,GO:0033004,GO:0043303,GO:0098742" transmembrane signaling receptor activity|protein binding|integral component of plasma membrane|cell surface receptor signaling pathway|negative regulation of mast cell activation|mast cell degranulation|cell-cell adhesion via plasma-membrane adhesion molecules MINAR1 32.94664441 32.25283036 33.64045846 1.043023452 0.060771597 0.979779001 1 0.16073156 0.164841445 23251 membrane integral NOTCH2 associated receptor 1 "GO:0001525,GO:0005515,GO:0005886,GO:0008285,GO:0010977,GO:0016021,GO:0016525,GO:0030308,GO:0031397,GO:0032007" angiogenesis|protein binding|plasma membrane|negative regulation of cell population proliferation|negative regulation of neuron projection development|integral component of membrane|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of protein ubiquitination|negative regulation of TOR signaling MINDY1 480.4163902 500.4390776 460.3937029 0.919979521 -0.120326348 0.667627571 1 6.614045023 5.98296532 55793 MINDY lysine 48 deubiquitinase 1 "GO:0004843,GO:0005515,GO:0005654,GO:0005829,GO:0008150,GO:0016604,GO:0016807,GO:0018215,GO:0036435,GO:0071108,GO:0071944,GO:1990380" thiol-dependent ubiquitin-specific protease activity|protein binding|nucleoplasm|cytosol|biological_process|nuclear body|cysteine-type carboxypeptidase activity|protein phosphopantetheinylation|K48-linked polyubiquitin modification-dependent protein binding|protein K48-linked deubiquitination|cell periphery|Lys48-specific deubiquitinase activity MINDY2 621.7698681 640.8949517 602.6447844 0.940317571 -0.088780018 0.738642605 1 3.658898765 3.382954244 54629 MINDY lysine 48 deubiquitinase 2 "GO:0004843,GO:0005654,GO:0005829,GO:0008150,GO:0016807,GO:0018215,GO:0036435,GO:0070530,GO:0071108,GO:0071795,GO:0071796,GO:0071944,GO:1990380" thiol-dependent ubiquitin-specific protease activity|nucleoplasm|cytosol|biological_process|cysteine-type carboxypeptidase activity|protein phosphopantetheinylation|K48-linked polyubiquitin modification-dependent protein binding|K63-linked polyubiquitin modification-dependent protein binding|protein K48-linked deubiquitination|K11-linked polyubiquitin modification-dependent protein binding|K6-linked polyubiquitin modification-dependent protein binding|cell periphery|Lys48-specific deubiquitinase activity MINDY3 654.3107764 586.7934298 721.828123 1.230123049 0.298802635 0.249020187 1 3.759885565 4.547726743 80013 MINDY lysine 48 deubiquitinase 3 "GO:0004843,GO:0005515,GO:0005654,GO:0006915,GO:0008234,GO:0018215,GO:0031965,GO:0071108,GO:1990380" thiol-dependent ubiquitin-specific protease activity|protein binding|nucleoplasm|apoptotic process|cysteine-type peptidase activity|protein phosphopantetheinylation|nuclear membrane|protein K48-linked deubiquitination|Lys48-specific deubiquitinase activity MINDY4 62.48961401 63.46524684 61.51398118 0.96925458 -0.045052447 0.966973776 1 1.239306103 1.181102609 84182 MINDY lysine 48 deubiquitinase 4 "GO:0004843,GO:0008234,GO:0018215,GO:0071108,GO:1990380" thiol-dependent ubiquitin-specific protease activity|cysteine-type peptidase activity|protein phosphopantetheinylation|protein K48-linked deubiquitination|Lys48-specific deubiquitinase activity MINK1 2618.554049 2671.782851 2565.325247 0.960154844 -0.058661007 0.805341825 1 27.09770814 25.58261981 50488 misshapen like kinase 1 "GO:0000165,GO:0001952,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005794,GO:0005829,GO:0006468,GO:0007165,GO:0007254,GO:0007268,GO:0007275,GO:0014069,GO:0022407,GO:0030033,GO:0030334,GO:0030424,GO:0030425,GO:0031098,GO:0031532,GO:0032147,GO:0046330,GO:0046777,GO:0048812,GO:0048813,GO:0070062,GO:0106310,GO:0106311,GO:1900745,GO:2000311" MAPK cascade|regulation of cell-matrix adhesion|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|Golgi apparatus|cytosol|protein phosphorylation|signal transduction|JNK cascade|chemical synaptic transmission|multicellular organism development|postsynaptic density|regulation of cell-cell adhesion|microvillus assembly|regulation of cell migration|axon|dendrite|stress-activated protein kinase signaling cascade|actin cytoskeleton reorganization|activation of protein kinase activity|positive regulation of JNK cascade|protein autophosphorylation|neuron projection morphogenesis|dendrite morphogenesis|extracellular exosome|protein serine kinase activity|protein threonine kinase activity|positive regulation of p38MAPK cascade|regulation of AMPA receptor activity MINPP1 1418.202164 1350.45722 1485.947108 1.100328901 0.137934826 0.565724634 1 24.70737737 26.73131645 9562 multiple inositol-polyphosphate phosphatase 1 "GO:0001503,GO:0003993,GO:0005515,GO:0005783,GO:0005788,GO:0006470,GO:0006797,GO:0030282,GO:0030351,GO:0034417,GO:0043647,GO:0051717,GO:0052745,GO:0052826,GO:0070062,GO:0101006" "ossification|acid phosphatase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|protein dephosphorylation|polyphosphate metabolic process|bone mineralization|inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity|bisphosphoglycerate 3-phosphatase activity|inositol phosphate metabolic process|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|inositol phosphate phosphatase activity|inositol hexakisphosphate 2-phosphatase activity|extracellular exosome|protein histidine phosphatase activity" "hsa00010,hsa00562" Glycolysis / Gluconeogenesis|Inositol phosphate metabolism MIOS 634.715291 715.8047513 553.6258307 0.773431344 -0.370654863 0.154326365 1 7.224127077 5.493869304 54468 meiosis regulator for oocyte development "GO:0005515,GO:0005654,GO:0005737,GO:0005765,GO:0005829,GO:0030054,GO:0032008,GO:0034198,GO:0034629,GO:0061700" protein binding|nucleoplasm|cytoplasm|lysosomal membrane|cytosol|cell junction|positive regulation of TOR signaling|cellular response to amino acid starvation|cellular protein-containing complex localization|GATOR2 complex hsa04150 mTOR signaling pathway MIOX 13.1687198 17.687036 8.650403604 0.489081585 -1.03185295 0.321609015 1 0.243908166 0.117294819 55586 myo-inositol oxygenase "GO:0004033,GO:0005737,GO:0005829,GO:0008199,GO:0016234,GO:0016651,GO:0016701,GO:0019310,GO:0043647,GO:0050113,GO:0055114" "aldo-keto reductase (NADP) activity|cytoplasm|cytosol|ferric iron binding|inclusion body|oxidoreductase activity, acting on NAD(P)H|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen|inositol catabolic process|inositol phosphate metabolic process|inositol oxygenase activity|oxidation-reduction process" "hsa00053,hsa00562" Ascorbate and aldarate metabolism|Inositol phosphate metabolism MIPEP 456.4176738 425.529278 487.3060697 1.14517636 0.195569794 0.486938301 1 7.214013811 8.123076108 4285 mitochondrial intermediate peptidase "GO:0004222,GO:0005739,GO:0005759,GO:0006508,GO:0006518,GO:0006627,GO:0046872" metalloendopeptidase activity|mitochondrion|mitochondrial matrix|proteolysis|peptide metabolic process|protein processing involved in protein targeting to mitochondrion|metal ion binding MIPOL1 256.4437435 260.1034707 252.7840164 0.971859452 -0.041180405 0.91343229 1 0.58155952 0.555736358 145282 mirror-image polydactyly 1 "GO:0005515,GO:0005634,GO:0042802" protein binding|nucleus|identical protein binding MIS12 839.7528965 837.5331755 841.9726175 1.005300616 0.007626977 0.981058835 1 16.24776672 16.06056437 79003 MIS12 kinetochore complex component "GO:0000070,GO:0000444,GO:0000777,GO:0000818,GO:0005515,GO:0005634,GO:0005829,GO:0007059,GO:0034501,GO:0051301,GO:0051315,GO:0051382" mitotic sister chromatid segregation|MIS12/MIND type complex|condensed chromosome kinetochore|nuclear MIS12/MIND complex|protein binding|nucleus|cytosol|chromosome segregation|protein localization to kinetochore|cell division|attachment of mitotic spindle microtubules to kinetochore|kinetochore assembly MIS18A 453.6184943 415.1251392 492.1118495 1.185454223 0.245439954 0.382281972 1 10.14398613 11.82400524 54069 MIS18 kinetochore protein A "GO:0000775,GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0007049,GO:0007059,GO:0034080,GO:0042802,GO:0044030,GO:0046872,GO:0051301" "chromosome, centromeric region|chromatin|protein binding|nucleus|nucleoplasm|cytosol|cell cycle|chromosome segregation|CENP-A containing nucleosome assembly|identical protein binding|regulation of DNA methylation|metal ion binding|cell division" MIS18BP1 2122.228895 2195.273292 2049.184498 0.933453026 -0.099350671 0.675532157 1 24.59229657 22.57162021 55320 MIS18 binding protein 1 "GO:0000778,GO:0003677,GO:0005515,GO:0005654,GO:0007049,GO:0034080,GO:0051301" condensed nuclear chromosome kinetochore|DNA binding|protein binding|nucleoplasm|cell cycle|CENP-A containing nucleosome assembly|cell division MISP 14.6500827 18.72744989 10.57271552 0.564557138 -0.824808493 0.41271093 1 0.313700433 0.17413826 126353 mitotic spindle positioning "GO:0000132,GO:0005515,GO:0005884,GO:0005886,GO:0005925,GO:0016477,GO:0030864,GO:0031616,GO:0043231,GO:0051015,GO:0051301,GO:0051640,GO:0051660,GO:0090307,GO:1904776,GO:1905721" establishment of mitotic spindle orientation|protein binding|actin filament|plasma membrane|focal adhesion|cell migration|cortical actin cytoskeleton|spindle pole centrosome|intracellular membrane-bounded organelle|actin filament binding|cell division|organelle localization|establishment of centrosome localization|mitotic spindle assembly|regulation of protein localization to cell cortex|mitotic spindle astral microtubule end MISP3 35.54767912 37.45489978 33.64045846 0.898159084 -0.154957094 0.858559181 1 1.312474827 1.159085379 113230 MISP family member 3 MITD1 620.110482 584.712602 655.508362 1.121077876 0.164886499 0.530858329 1 21.65512624 23.87083883 129531 microtubule interacting and trafficking domain containing 1 "GO:0000281,GO:0005515,GO:0019898,GO:0019904,GO:0030496,GO:0031902,GO:0032091,GO:0035091,GO:0039702,GO:0042802,GO:0043231,GO:0061952,GO:0070062,GO:0071985" mitotic cytokinesis|protein binding|extrinsic component of membrane|protein domain specific binding|midbody|late endosome membrane|negative regulation of protein binding|phosphatidylinositol binding|viral budding via host ESCRT complex|identical protein binding|intracellular membrane-bounded organelle|midbody abscission|extracellular exosome|multivesicular body sorting pathway MITF 349.5664308 332.9324424 366.2004192 1.099924106 0.137403983 0.653562442 1 2.825249253 3.055558955 4286 melanocyte inducing transcription factor "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0006355,GO:0006357,GO:0010628,GO:0030316,GO:0030318,GO:0030336,GO:0032991,GO:0042127,GO:0043010,GO:0044336,GO:0045165,GO:0045670,GO:0045893,GO:0045944,GO:0046849,GO:0046983,GO:0065003,GO:0070888,GO:2000144,GO:2001141" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|chromatin binding|protein binding|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|positive regulation of gene expression|osteoclast differentiation|melanocyte differentiation|negative regulation of cell migration|protein-containing complex|regulation of cell population proliferation|camera-type eye development|canonical Wnt signaling pathway involved in negative regulation of apoptotic process|cell fate commitment|regulation of osteoclast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|bone remodeling|protein dimerization activity|protein-containing complex assembly|E-box binding|positive regulation of DNA-templated transcription, initiation|regulation of RNA biosynthetic process" "hsa04137,hsa04380,hsa04916,hsa05200,hsa05202,hsa05218" Mitophagy - animal|Osteoclast differentiation|Melanogenesis|Pathways in cancer|Transcriptional misregulation in cancer|Melanoma bHLH MIX23 219.2561857 217.4465015 221.0658699 1.016644868 0.023815809 0.960257801 1 12.31923581 12.31471087 131076 mitochondrial matrix import factor 23 GO:0005739 mitochondrion MKI67 8461.762484 10074.32763 6849.197342 0.679866448 -0.556676721 0.024977672 0.86041596 40.6447195 27.17058058 4288 marker of proliferation Ki-67 "GO:0000793,GO:0003677,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0007049,GO:0007088,GO:0008022,GO:0008283,GO:0016020,GO:0016604,GO:0051983,GO:1902275" condensed chromosome|DNA binding|RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|chromosome|nucleolus|cell cycle|regulation of mitotic nuclear division|protein C-terminus binding|cell population proliferation|membrane|nuclear body|regulation of chromosome segregation|regulation of chromatin organization MKKS 1211.088761 1212.082173 1210.095349 0.998360817 -0.002366782 0.996105305 1 9.299395899 9.128794768 8195 McKusick-Kaufman syndrome "GO:0001103,GO:0001947,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0006457,GO:0007286,GO:0007368,GO:0007507,GO:0007601,GO:0007608,GO:0008406,GO:0010629,GO:0014824,GO:0021756,GO:0021766,GO:0021987,GO:0030837,GO:0031514,GO:0032402,GO:0032502,GO:0034260,GO:0035176,GO:0038108,GO:0040018,GO:0042311,GO:0045444,GO:0045494,GO:0045776,GO:0046907,GO:0048854,GO:0050910,GO:0051082,GO:0051131,GO:0051216,GO:0051492,GO:0051877,GO:0060027,GO:0060271,GO:0060296,GO:0060324,GO:1902636,GO:1905515" RNA polymerase II repressing transcription factor binding|heart looping|protein binding|ATP binding|nucleus|cytoplasm|centrosome|cytosol|protein folding|spermatid development|determination of left/right symmetry|heart development|visual perception|sensory perception of smell|gonad development|negative regulation of gene expression|artery smooth muscle contraction|striatum development|hippocampus development|cerebral cortex development|negative regulation of actin filament polymerization|motile cilium|melanosome transport|developmental process|negative regulation of GTPase activity|social behavior|negative regulation of appetite by leptin-mediated signaling pathway|positive regulation of multicellular organism growth|vasodilation|fat cell differentiation|photoreceptor cell maintenance|negative regulation of blood pressure|intracellular transport|brain morphogenesis|detection of mechanical stimulus involved in sensory perception of sound|unfolded protein binding|chaperone-mediated protein complex assembly|cartilage development|regulation of stress fiber assembly|pigment granule aggregation in cell center|convergent extension involved in gastrulation|cilium assembly|regulation of cilium beat frequency involved in ciliary motility|face development|kinociliary basal body|non-motile cilium assembly MKLN1 2183.167335 2331.567511 2034.767159 0.872703514 -0.196436489 0.406339395 1 10.78729717 9.256579722 4289 muskelin 1 "GO:0000151,GO:0001726,GO:0002090,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005938,GO:0007160,GO:0007165,GO:0008360,GO:0031532,GO:0042802,GO:0042803,GO:0098794" ubiquitin ligase complex|ruffle|regulation of receptor internalization|protein binding|nucleoplasm|cytoplasm|cytosol|cell cortex|cell-matrix adhesion|signal transduction|regulation of cell shape|actin cytoskeleton reorganization|identical protein binding|protein homodimerization activity|postsynapse MKNK1 567.5192768 604.4804658 530.5580877 0.877709236 -0.188185007 0.481346495 1 7.916567233 6.832171373 8569 MAPK interacting serine/threonine kinase 1 "GO:0004674,GO:0004683,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006417,GO:0006468,GO:0009931,GO:0018105,GO:0035556,GO:0046777,GO:0046872,GO:0106310,GO:0106311" protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|protein binding|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of translation|protein phosphorylation|calcium-dependent protein serine/threonine kinase activity|peptidyl-serine phosphorylation|intracellular signal transduction|protein autophosphorylation|metal ion binding|protein serine kinase activity|protein threonine kinase activity "hsa04010,hsa04066,hsa04910" MAPK signaling pathway|HIF-1 signaling pathway|Insulin signaling pathway MKNK2 1986.844914 2148.454668 1825.23516 0.849557213 -0.235216986 0.320379963 1 30.293019 25.30500151 2872 MAPK interacting serine/threonine kinase 2 "GO:0004674,GO:0004683,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006417,GO:0006468,GO:0007166,GO:0009931,GO:0016604,GO:0016605,GO:0018105,GO:0030097,GO:0035556,GO:0046777,GO:0046872,GO:0071243,GO:0097192,GO:0106310,GO:0106311" protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|protein binding|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|regulation of translation|protein phosphorylation|cell surface receptor signaling pathway|calcium-dependent protein serine/threonine kinase activity|nuclear body|PML body|peptidyl-serine phosphorylation|hemopoiesis|intracellular signal transduction|protein autophosphorylation|metal ion binding|cellular response to arsenic-containing substance|extrinsic apoptotic signaling pathway in absence of ligand|protein serine kinase activity|protein threonine kinase activity "hsa04010,hsa04066,hsa04910" MAPK signaling pathway|HIF-1 signaling pathway|Insulin signaling pathway MKRN1 2445.086749 2420.002691 2470.170807 1.020730603 0.029602153 0.902047983 1 31.26388183 31.37799685 23608 makorin ring finger protein 1 "GO:0000209,GO:0003723,GO:0005515,GO:0005575,GO:0005829,GO:0016567,GO:0046872,GO:0061630" protein polyubiquitination|RNA binding|protein binding|cellular_component|cytosol|protein ubiquitination|metal ion binding|ubiquitin protein ligase activity MKRN2 994.0568276 1040.413883 947.6997726 0.910887281 -0.134655558 0.586040776 1 20.00900062 17.92095768 23609 makorin ring finger protein 2 "GO:0003723,GO:0005515,GO:0008150,GO:0016567,GO:0046872,GO:0061630" RNA binding|protein binding|biological_process|protein ubiquitination|metal ion binding|ubiquitin protein ligase activity MKS1 220.6582906 216.4060876 224.9104937 1.039298368 0.055609892 0.886807178 1 4.301376222 4.395606977 54903 MKS transition zone complex subunit 1 "GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0036038,GO:0036064,GO:0060271,GO:0097711" protein binding|cytoplasm|centrosome|cytosol|MKS complex|ciliary basal body|cilium assembly|ciliary basal body-plasma membrane docking MKX 70.37197606 81.15228285 59.59166927 0.734319075 -0.445521018 0.406879413 1 0.96780965 0.698788801 283078 mohawk homeobox "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0007517,GO:0048468" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|muscle organ development|cell development" MLEC 5568.83512 4627.76095 6509.90929 1.406708203 0.492323098 0.041577116 1 22.75848659 31.47882964 9761 malectin "GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0005975,GO:0006457,GO:0016020,GO:0016021,GO:0019899,GO:0030246,GO:0035579,GO:0043312" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|carbohydrate metabolic process|protein folding|membrane|integral component of membrane|enzyme binding|carbohydrate binding|specific granule membrane|neutrophil degranulation MLF1 818.0230918 796.9570341 839.0891496 1.052866232 0.074322152 0.771070722 1 16.20889183 16.7802219 4291 myeloid leukemia factor 1 "GO:0002318,GO:0003677,GO:0005515,GO:0005634,GO:0005737,GO:0005929,GO:0006351,GO:0006355,GO:0007050,GO:0019904,GO:0036064" "myeloid progenitor cell differentiation|DNA binding|protein binding|nucleus|cytoplasm|cilium|transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle arrest|protein domain specific binding|ciliary basal body" hsa05202 Transcriptional misregulation in cancer MLF2 3193.467506 2915.239699 3471.695313 1.190878168 0.252025827 0.287584605 1 97.84967595 114.5771206 8079 myeloid leukemia factor 2 "GO:0005515,GO:0005634,GO:0005737,GO:0006355,GO:0016020" "protein binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|membrane" MLH1 1211.673749 1151.738168 1271.60933 1.104078483 0.14284273 0.556436075 1 21.99933759 23.88255184 4292 mutL homolog 1 "GO:0000289,GO:0000712,GO:0000795,GO:0001673,GO:0003682,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005715,GO:0006298,GO:0006303,GO:0007060,GO:0007129,GO:0007283,GO:0008630,GO:0009617,GO:0016020,GO:0016321,GO:0016446,GO:0016887,GO:0019899,GO:0032137,GO:0032300,GO:0032389,GO:0032407,GO:0043060,GO:0045141,GO:0045190,GO:0045950,GO:0048298,GO:0048304,GO:0048477,GO:0051257" nuclear-transcribed mRNA poly(A) tail shortening|resolution of meiotic recombination intermediates|synaptonemal complex|male germ cell nucleus|chromatin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|chromosome|late recombination nodule|mismatch repair|double-strand break repair via nonhomologous end joining|male meiosis chromosome segregation|homologous chromosome pairing at meiosis|spermatogenesis|intrinsic apoptotic signaling pathway in response to DNA damage|response to bacterium|membrane|female meiosis chromosome segregation|somatic hypermutation of immunoglobulin genes|ATPase activity|enzyme binding|guanine/thymine mispair binding|mismatch repair complex|MutLalpha complex|MutSalpha complex binding|meiotic metaphase I plate congression|meiotic telomere clustering|isotype switching|negative regulation of mitotic recombination|positive regulation of isotype switching to IgA isotypes|positive regulation of isotype switching to IgG isotypes|oogenesis|meiotic spindle midzone assembly "hsa01524,hsa03430,hsa03460,hsa05200,hsa05210,hsa05213,hsa05226" Platinum drug resistance|Mismatch repair|Fanconi anemia pathway|Pathways in cancer|Colorectal cancer|Endometrial cancer|Gastric cancer MLH3 590.5373299 628.4099851 552.6646747 0.879465139 -0.185301703 0.484603119 1 4.281512312 3.702431266 27030 mutL homolog 3 "GO:0000795,GO:0001673,GO:0003682,GO:0003696,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005712,GO:0006298,GO:0007130,GO:0007131,GO:0007140,GO:0007144,GO:0008104,GO:0016887,GO:0019237,GO:0030983,GO:0032300" synaptonemal complex|male germ cell nucleus|chromatin binding|satellite DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|chiasma|mismatch repair|synaptonemal complex assembly|reciprocal meiotic recombination|male meiotic nuclear division|female meiosis I|protein localization|ATPase activity|centromeric DNA binding|mismatched DNA binding|mismatch repair complex hsa03430 Mismatch repair MLKL 687.1228283 754.3000649 619.9455916 0.821881928 -0.282996945 0.271073457 1 15.31796352 12.37888819 197259 mixed lineage kinase domain like pseudokinase "GO:0004672,GO:0004706,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0007166,GO:0007256,GO:0007257,GO:0019901,GO:0030054,GO:0044877,GO:0051607,GO:0070207,GO:0070266,GO:0097527,GO:0097528" protein kinase activity|JUN kinase kinase kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|protein phosphorylation|cell surface receptor signaling pathway|activation of JNKK activity|activation of JUN kinase activity|protein kinase binding|cell junction|protein-containing complex binding|defense response to virus|protein homotrimerization|necroptotic process|necroptotic signaling pathway|execution phase of necroptosis "hsa04217,hsa04668,hsa05132" Necroptosis|TNF signaling pathway|Salmonella infection MLLT1 999.586604 933.2512527 1065.921955 1.142159683 0.191764365 0.43649765 1 9.142052885 10.26695678 4298 MLLT1 super elongation complex subunit "GO:0001650,GO:0005515,GO:0005654,GO:0005829,GO:0006355,GO:0006366,GO:0006368,GO:0006469,GO:0008023" "fibrillar center|protein binding|nucleoplasm|cytosol|regulation of transcription, DNA-templated|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|negative regulation of protein kinase activity|transcription elongation factor complex" hsa05202 Transcriptional misregulation in cancer MLLT10 707.9216595 719.9664068 695.8769121 0.966540807 -0.04909745 0.852957717 1 4.149830855 3.943862533 8028 MLLT10 histone lysine methyltransferase DOT1L cofactor "GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0031491,GO:0032991,GO:0042393,GO:0045944,GO:0046872" DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|cytosol|nucleosome binding|protein-containing complex|histone binding|positive regulation of transcription by RNA polymerase II|metal ion binding MLLT11 1071.845679 1101.798302 1041.893056 0.945629572 -0.080652943 0.744190001 1 23.68141375 22.01911447 10962 MLLT11 transcription factor 7 cofactor "GO:0003674,GO:0005515,GO:0005654,GO:0005815,GO:0005829,GO:0043065,GO:0045893,GO:0051901,GO:0090200,GO:0097191,GO:0097193" "molecular_function|protein binding|nucleoplasm|microtubule organizing center|cytosol|positive regulation of apoptotic process|positive regulation of transcription, DNA-templated|positive regulation of mitochondrial depolarization|positive regulation of release of cytochrome c from mitochondria|extrinsic apoptotic signaling pathway|intrinsic apoptotic signaling pathway" MLLT3 291.8530285 243.4568485 340.2492084 1.397575014 0.482925721 0.128202451 1 1.873787792 2.574937614 4300 MLLT3 super elongation complex subunit "GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006366,GO:0006368,GO:0007379,GO:0008023,GO:0009952,GO:0042393,GO:0045893,GO:0060218,GO:0070062,GO:0070577,GO:0090090,GO:0140030,GO:1902275,GO:2000035,GO:2000096" "DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|chromosome|cytosol|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|segment specification|transcription elongation factor complex|anterior/posterior pattern specification|histone binding|positive regulation of transcription, DNA-templated|hematopoietic stem cell differentiation|extracellular exosome|lysine-acetylated histone binding|negative regulation of canonical Wnt signaling pathway|modification-dependent protein binding|regulation of chromatin organization|regulation of stem cell division|positive regulation of Wnt signaling pathway, planar cell polarity pathway" hsa05202 Transcriptional misregulation in cancer MLLT6 2831.562721 2889.229352 2773.896089 0.960081652 -0.058770987 0.804989726 1 19.6699656 18.56876196 4302 "MLLT6, PHD finger containing" "GO:0005515,GO:0005634,GO:0006355,GO:0010765,GO:0031491,GO:0035811,GO:0035812,GO:0036359,GO:0042393,GO:0045944,GO:0046872,GO:2001161" "protein binding|nucleus|regulation of transcription, DNA-templated|positive regulation of sodium ion transport|nucleosome binding|negative regulation of urine volume|renal sodium excretion|renal potassium excretion|histone binding|positive regulation of transcription by RNA polymerase II|metal ion binding|negative regulation of histone H3-K79 methylation" MLPH 1530.449819 1269.304937 1791.594702 1.411476982 0.497205602 0.037189635 0.976206556 12.50054837 17.34898389 79083 melanophilin "GO:0003779,GO:0005515,GO:0006886,GO:0017022,GO:0030425,GO:0030674,GO:0030864,GO:0031267,GO:0032402,GO:0046872,GO:0048471,GO:0070062" actin binding|protein binding|intracellular protein transport|myosin binding|dendrite|protein-macromolecule adaptor activity|cortical actin cytoskeleton|small GTPase binding|melanosome transport|metal ion binding|perinuclear region of cytoplasm|extracellular exosome MLST8 481.5310316 517.0856997 445.9763636 0.86248056 -0.213436156 0.441094743 1 8.680689974 7.361642773 64223 "MTOR associated protein, LST8 homolog" "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0007050,GO:0016241,GO:0031929,GO:0031931,GO:0031932,GO:0032008,GO:0032148,GO:0032956,GO:0038202,GO:0043539,GO:0071902,GO:1900034" protein binding|nucleoplasm|cytoplasm|cytosol|cell cycle arrest|regulation of macroautophagy|TOR signaling|TORC1 complex|TORC2 complex|positive regulation of TOR signaling|activation of protein kinase B activity|regulation of actin cytoskeleton organization|TORC1 signaling|protein serine/threonine kinase activator activity|positive regulation of protein serine/threonine kinase activity|regulation of cellular response to heat "hsa04136,hsa04140,hsa04150,hsa04151,hsa04714" Autophagy - other|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Thermogenesis MLX 1134.940403 1054.979677 1214.901128 1.151587234 0.203623701 0.403257624 1 23.85691796 27.01359333 6945 MAX dimerization protein MLX "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0008134,GO:0031965,GO:0042803,GO:0045892,GO:0045944,GO:0046982,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription factor binding|nuclear membrane|protein homodimerization activity|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|sequence-specific double-stranded DNA binding" "hsa04931,hsa04932" Insulin resistance|Non-alcoholic fatty liver disease MLXIP 1355.904435 1506.519302 1205.289569 0.800049204 -0.321839364 0.179861194 1 9.259491683 7.284085286 22877 MLX interacting protein "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0005634,GO:0005741,GO:0006357,GO:0045944,GO:0046983" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|mitochondrial outer membrane|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|protein dimerization activity" "hsa04931,hsa04932" Insulin resistance|Non-alcoholic fatty liver disease MLYCD 133.6642302 140.4558742 126.8725862 0.903291421 -0.146736588 0.742156333 1 0.574220305 0.510008729 23417 malonyl-CoA decarboxylase "GO:0002931,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0005782,GO:0005829,GO:0006085,GO:0006625,GO:0006633,GO:0006637,GO:0010906,GO:0019395,GO:0031998,GO:0042802,GO:0046321,GO:0050080,GO:2001294" response to ischemia|cytoplasm|mitochondrion|mitochondrial matrix|peroxisome|peroxisomal matrix|cytosol|acetyl-CoA biosynthetic process|protein targeting to peroxisome|fatty acid biosynthetic process|acyl-CoA metabolic process|regulation of glucose metabolic process|fatty acid oxidation|regulation of fatty acid beta-oxidation|identical protein binding|positive regulation of fatty acid oxidation|malonyl-CoA decarboxylase activity|malonyl-CoA catabolic process "hsa00410,hsa00640,hsa04146,hsa04152" beta-Alanine metabolism|Propanoate metabolism|Peroxisome|AMPK signaling pathway MMAA 53.03657031 67.62690237 38.44623824 0.56850509 -0.814754828 0.165446564 1 0.713124577 0.398630882 166785 metabolism of cobalamin associated A "GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005739,GO:0005759,GO:0009235,GO:0019626,GO:0042802,GO:0042803" GTPase activity|protein binding|GTP binding|cytoplasm|mitochondrion|mitochondrial matrix|cobalamin metabolic process|short-chain fatty acid catabolic process|identical protein binding|protein homodimerization activity MMAB 247.3970503 249.6993318 245.0947688 0.98155957 -0.026852269 0.949357087 1 2.33584477 2.254404374 326625 metabolism of cobalamin associated B "GO:0005515,GO:0005524,GO:0005759,GO:0008817,GO:0009235,GO:0031419" "protein binding|ATP binding|mitochondrial matrix|cob(I)yrinic acid a,c-diamide adenosyltransferase activity|cobalamin metabolic process|cobalamin binding" hsa00860 Porphyrin and chlorophyll metabolism MMACHC 211.7254539 221.608157 201.8427508 0.910809212 -0.134779212 0.714393597 1 2.287143694 2.048292825 25974 metabolism of cobalamin associated C "GO:0005515,GO:0005737,GO:0005829,GO:0006749,GO:0009235,GO:0016491,GO:0016740,GO:0031419,GO:0032451,GO:0033787,GO:0042803,GO:0043295,GO:0055114,GO:0070988,GO:0071949" protein binding|cytoplasm|cytosol|glutathione metabolic process|cobalamin metabolic process|oxidoreductase activity|transferase activity|cobalamin binding|demethylase activity|cyanocobalamin reductase (cyanide-eliminating) activity|protein homodimerization activity|glutathione binding|oxidation-reduction process|demethylation|FAD binding hsa04977 Vitamin digestion and absorption MMADHC 2594.250204 2260.819367 2927.681042 1.294964598 0.372912657 0.114856967 1 86.67799885 110.3666729 27249 metabolism of cobalamin associated D "GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0009235" protein binding|cytoplasm|mitochondrion|cytosol|cobalamin metabolic process MMD 787.3006998 810.4824146 764.118985 0.942795268 -0.084983578 0.739858995 1 16.21820655 15.03458344 23531 monocyte to macrophage differentiation associated "GO:0004672,GO:0005515,GO:0005765,GO:0005794,GO:0005887,GO:0006468,GO:0016020,GO:0019835,GO:0031902,GO:0032880,GO:0038023,GO:0045666,GO:0045860" protein kinase activity|protein binding|lysosomal membrane|Golgi apparatus|integral component of plasma membrane|protein phosphorylation|membrane|cytolysis|late endosome membrane|regulation of protein localization|signaling receptor activity|positive regulation of neuron differentiation|positive regulation of protein kinase activity MME 4403.991516 4932.602218 3875.380815 0.7856666 -0.348010864 0.145278115 1 28.27235685 21.84094793 4311 membrane metalloendopeptidase "GO:0001786,GO:0001822,GO:0001890,GO:0002003,GO:0004175,GO:0004222,GO:0005515,GO:0005737,GO:0005769,GO:0005802,GO:0005886,GO:0005887,GO:0005903,GO:0005925,GO:0006508,GO:0006518,GO:0007568,GO:0007611,GO:0008021,GO:0008237,GO:0008238,GO:0008270,GO:0009986,GO:0016021,GO:0016485,GO:0019233,GO:0030324,GO:0030424,GO:0030425,GO:0030667,GO:0031410,GO:0042277,GO:0042803,GO:0043025,GO:0043312,GO:0044306,GO:0045121,GO:0045202,GO:0046449,GO:0050435,GO:0050769,GO:0061837,GO:0070012,GO:0070062,GO:0071345,GO:0071492,GO:0071493,GO:0090399,GO:0097242,GO:0098793,GO:0150094,GO:1900273,GO:1901612" phosphatidylserine binding|kidney development|placenta development|angiotensin maturation|endopeptidase activity|metalloendopeptidase activity|protein binding|cytoplasm|early endosome|trans-Golgi network|plasma membrane|integral component of plasma membrane|brush border|focal adhesion|proteolysis|peptide metabolic process|aging|learning or memory|synaptic vesicle|metallopeptidase activity|exopeptidase activity|zinc ion binding|cell surface|integral component of membrane|protein processing|sensory perception of pain|lung development|axon|dendrite|secretory granule membrane|cytoplasmic vesicle|peptide binding|protein homodimerization activity|neuronal cell body|neutrophil degranulation|neuron projection terminus|membrane raft|synapse|creatinine metabolic process|amyloid-beta metabolic process|positive regulation of neurogenesis|neuropeptide processing|oligopeptidase activity|extracellular exosome|cellular response to cytokine stimulus|cellular response to UV-A|cellular response to UV-B|replicative senescence|amyloid-beta clearance|presynapse|amyloid-beta clearance by cellular catabolic process|positive regulation of long-term synaptic potentiation|cardiolipin binding "hsa04614,hsa04640,hsa04974,hsa05010" Renin-angiotensin system|Hematopoietic cell lineage|Protein digestion and absorption|Alzheimer disease MMGT1 1807.388611 1752.056978 1862.720243 1.06316191 0.088361322 0.710915584 1 18.17377275 18.99834108 93380 membrane magnesium transporter 1 "GO:0000139,GO:0005515,GO:0005769,GO:0005794,GO:0005886,GO:0006824,GO:0006825,GO:0015087,GO:0015093,GO:0015095,GO:0015693,GO:0016020,GO:0016021,GO:0022890,GO:0030176,GO:0031901,GO:0032977,GO:0034755,GO:0045050,GO:0071816,GO:0072546,GO:1903830" Golgi membrane|protein binding|early endosome|Golgi apparatus|plasma membrane|cobalt ion transport|copper ion transport|cobalt ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane|inorganic cation transmembrane transporter activity|integral component of endoplasmic reticulum membrane|early endosome membrane|membrane insertase activity|iron ion transmembrane transport|protein insertion into ER membrane by stop-transfer membrane-anchor sequence|tail-anchored membrane protein insertion into ER membrane|EMC complex|magnesium ion transmembrane transport MMP1 204.5966565 122.7688382 286.4244749 2.333038898 1.222210361 0.000801136 0.171180146 3.324174151 7.625651022 4312 matrix metallopeptidase 1 "GO:0004175,GO:0004222,GO:0004252,GO:0005576,GO:0006508,GO:0008233,GO:0008270,GO:0016032,GO:0019221,GO:0022617,GO:0030198,GO:0030574,GO:0031012,GO:0031334,GO:0044267,GO:0050900,GO:0071492" endopeptidase activity|metalloendopeptidase activity|serine-type endopeptidase activity|extracellular region|proteolysis|peptidase activity|zinc ion binding|viral process|cytokine-mediated signaling pathway|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|extracellular matrix|positive regulation of protein-containing complex assembly|cellular protein metabolic process|leukocyte migration|cellular response to UV-A "hsa03320,hsa04657,hsa04926,hsa05171,hsa05200,hsa05219,hsa05323" PPAR signaling pathway|IL-17 signaling pathway|Relaxin signaling pathway|Coronavirus disease - COVID-19|Pathways in cancer|Bladder cancer|Rheumatoid arthritis MMP10 21.81912341 17.687036 25.95121081 1.467244755 0.553109551 0.525459936 1 0.536625699 0.774185818 4319 matrix metallopeptidase 10 "GO:0004222,GO:0005576,GO:0005615,GO:0006508,GO:0008270,GO:0022617,GO:0030198,GO:0030574,GO:0031012" metalloendopeptidase activity|extracellular region|extracellular space|proteolysis|zinc ion binding|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|extracellular matrix MMP11 171.0052735 199.7594655 142.2510815 0.712111845 -0.489824245 0.20478981 1 4.715079845 3.301478244 4320 matrix metallopeptidase 11 "GO:0004222,GO:0005576,GO:0005796,GO:0006508,GO:0007275,GO:0008270,GO:0022617,GO:0030198,GO:0030199,GO:0030574,GO:0031012,GO:0045599,GO:0071711" metalloendopeptidase activity|extracellular region|Golgi lumen|proteolysis|multicellular organism development|zinc ion binding|extracellular matrix disassembly|extracellular matrix organization|collagen fibril organization|collagen catabolic process|extracellular matrix|negative regulation of fat cell differentiation|basement membrane organization MMP12 4.003139677 4.161655531 3.844623824 0.923820772 -0.11431511 1 1 0.121898961 0.11072837 4321 matrix metallopeptidase 12 "GO:0000122,GO:0001046,GO:0004175,GO:0004222,GO:0005509,GO:0005518,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0006508,GO:0006606,GO:0008270,GO:0022617,GO:0030198,GO:0030574,GO:0031012,GO:0032727,GO:0035313,GO:0043565,GO:0045944,GO:0048286,GO:0050691,GO:0060054,GO:0060309,GO:0060339,GO:0060340,GO:0060435,GO:0098586,GO:1904645,GO:1904905" "negative regulation of transcription by RNA polymerase II|core promoter sequence-specific DNA binding|endopeptidase activity|metalloendopeptidase activity|calcium ion binding|collagen binding|extracellular region|extracellular space|nucleus|cytoplasm|proteolysis|protein import into nucleus|zinc ion binding|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|extracellular matrix|positive regulation of interferon-alpha production|wound healing, spreading of epidermal cells|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|lung alveolus development|regulation of defense response to virus by host|positive regulation of epithelial cell proliferation involved in wound healing|elastin catabolic process|negative regulation of type I interferon-mediated signaling pathway|positive regulation of type I interferon-mediated signaling pathway|bronchiole development|cellular response to virus|response to amyloid-beta|negative regulation of endothelial cell-matrix adhesion via fibronectin" MMP13 5.444873611 4.161655531 6.728091692 1.616686351 0.693039812 0.747994079 1 0.081834896 0.130087475 4322 matrix metallopeptidase 13 "GO:0004175,GO:0004222,GO:0005509,GO:0005518,GO:0005576,GO:0005615,GO:0006508,GO:0008270,GO:0022617,GO:0030198,GO:0030574,GO:0031012,GO:0060349,GO:1904645" endopeptidase activity|metalloendopeptidase activity|calcium ion binding|collagen binding|extracellular region|extracellular space|proteolysis|zinc ion binding|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|extracellular matrix|bone morphogenesis|response to amyloid-beta "hsa04657,hsa04926,hsa04928" "IL-17 signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action" MMP14 10742.78617 9675.849109 11809.72323 1.22053611 0.287514978 0.255955668 1 139.5250698 167.4457233 4323 matrix metallopeptidase 14 "GO:0001501,GO:0001525,GO:0001541,GO:0001666,GO:0001935,GO:0001958,GO:0004175,GO:0004222,GO:0005178,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005796,GO:0005829,GO:0005886,GO:0005887,GO:0005925,GO:0006508,GO:0006979,GO:0008270,GO:0008584,GO:0009612,GO:0010831,GO:0010954,GO:0014070,GO:0016485,GO:0022617,GO:0030198,GO:0030307,GO:0030324,GO:0030335,GO:0030574,GO:0031012,GO:0031410,GO:0031638,GO:0035987,GO:0035988,GO:0042470,GO:0043615,GO:0043627,GO:0044354,GO:0045111,GO:0045579,GO:0045746,GO:0048701,GO:0048754,GO:0048771,GO:0048870,GO:0051895,GO:0060322,GO:0070006,GO:0097094,GO:1903076,GO:1905523,GO:1990834" skeletal system development|angiogenesis|ovarian follicle development|response to hypoxia|endothelial cell proliferation|endochondral ossification|endopeptidase activity|metalloendopeptidase activity|integrin binding|protein binding|extracellular space|nucleus|cytoplasm|Golgi lumen|cytosol|plasma membrane|integral component of plasma membrane|focal adhesion|proteolysis|response to oxidative stress|zinc ion binding|male gonad development|response to mechanical stimulus|positive regulation of myotube differentiation|positive regulation of protein processing|response to organic cyclic compound|protein processing|extracellular matrix disassembly|extracellular matrix organization|positive regulation of cell growth|lung development|positive regulation of cell migration|collagen catabolic process|extracellular matrix|cytoplasmic vesicle|zymogen activation|endodermal cell differentiation|chondrocyte proliferation|melanosome|astrocyte cell migration|response to estrogen|macropinosome|intermediate filament cytoskeleton|positive regulation of B cell differentiation|negative regulation of Notch signaling pathway|embryonic cranial skeleton morphogenesis|branching morphogenesis of an epithelial tube|tissue remodeling|cell motility|negative regulation of focal adhesion assembly|head development|metalloaminopeptidase activity|craniofacial suture morphogenesis|regulation of protein localization to plasma membrane|positive regulation of macrophage migration|response to odorant "hsa04668,hsa04912,hsa04928" "TNF signaling pathway|GnRH signaling pathway|Parathyroid hormone synthesis, secretion and action" MMP15 148.3388506 197.6786377 98.99906347 0.500808103 -0.997670191 0.014545729 0.708244576 2.597180102 1.278923573 4324 matrix metallopeptidase 15 "GO:0004222,GO:0005515,GO:0005886,GO:0005887,GO:0006464,GO:0006508,GO:0008047,GO:0008270,GO:0022617,GO:0030198,GO:0030574,GO:0031012,GO:0032355,GO:0035987,GO:0050790,GO:0070006" metalloendopeptidase activity|protein binding|plasma membrane|integral component of plasma membrane|cellular protein modification process|proteolysis|enzyme activator activity|zinc ion binding|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|extracellular matrix|response to estradiol|endodermal cell differentiation|regulation of catalytic activity|metalloaminopeptidase activity hsa04928 "Parathyroid hormone synthesis, secretion and action" MMP16 540.4634854 562.8639105 518.0630603 0.920405538 -0.119658431 0.66032206 1 1.498429311 1.356084217 4325 matrix metallopeptidase 16 "GO:0001501,GO:0001958,GO:0004222,GO:0005796,GO:0005886,GO:0005887,GO:0006508,GO:0008047,GO:0008270,GO:0009986,GO:0016485,GO:0022617,GO:0030198,GO:0030574,GO:0031012,GO:0035988,GO:0048701,GO:0050790,GO:0070006,GO:0097094" skeletal system development|endochondral ossification|metalloendopeptidase activity|Golgi lumen|plasma membrane|integral component of plasma membrane|proteolysis|enzyme activator activity|zinc ion binding|cell surface|protein processing|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|extracellular matrix|chondrocyte proliferation|embryonic cranial skeleton morphogenesis|regulation of catalytic activity|metalloaminopeptidase activity|craniofacial suture morphogenesis "hsa04928,hsa05206" "Parathyroid hormone synthesis, secretion and action|MicroRNAs in cancer" MMP17 279.6102517 313.1645787 246.0559247 0.785708032 -0.347934787 0.282247318 1 5.38261449 4.158394114 4326 matrix metallopeptidase 17 "GO:0004222,GO:0005886,GO:0006508,GO:0008047,GO:0008270,GO:0030198,GO:0030574,GO:0031012,GO:0031225,GO:0050790,GO:0070006" metalloendopeptidase activity|plasma membrane|proteolysis|enzyme activator activity|zinc ion binding|extracellular matrix organization|collagen catabolic process|extracellular matrix|anchored component of membrane|regulation of catalytic activity|metalloaminopeptidase activity hsa04928 "Parathyroid hormone synthesis, secretion and action" MMP19 160.9181664 187.2744989 134.5618338 0.718527267 -0.476885189 0.228046573 1 2.961332092 2.092192039 4327 matrix metallopeptidase 19 "GO:0001525,GO:0001541,GO:0001542,GO:0001554,GO:0004222,GO:0005576,GO:0005615,GO:0006508,GO:0008270,GO:0009725,GO:0022617,GO:0030154,GO:0030198,GO:0030574,GO:0031012,GO:0051591" angiogenesis|ovarian follicle development|ovulation from ovarian follicle|luteolysis|metalloendopeptidase activity|extracellular region|extracellular space|proteolysis|zinc ion binding|response to hormone|extracellular matrix disassembly|cell differentiation|extracellular matrix organization|collagen catabolic process|extracellular matrix|response to cAMP MMP23B 2.40288989 0 4.80577978 Inf Inf 0.18976424 1 0 0.117404032 8510 matrix metallopeptidase 23B "GO:0000003,GO:0004222,GO:0005615,GO:0005789,GO:0006508,GO:0008237,GO:0008270,GO:0016021,GO:0030198,GO:0030574,GO:0031012,GO:0062023" reproduction|metalloendopeptidase activity|extracellular space|endoplasmic reticulum membrane|proteolysis|metallopeptidase activity|zinc ion binding|integral component of membrane|extracellular matrix organization|collagen catabolic process|extracellular matrix|collagen-containing extracellular matrix MMP24 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.024162305 0.032922175 10893 matrix metallopeptidase 24 "GO:0004222,GO:0005887,GO:0006508,GO:0008047,GO:0008270,GO:0010001,GO:0030198,GO:0030574,GO:0031012,GO:0032588,GO:0044331,GO:0045296,GO:0050790,GO:0050965,GO:0070062,GO:0097150,GO:0098742" metalloendopeptidase activity|integral component of plasma membrane|proteolysis|enzyme activator activity|zinc ion binding|glial cell differentiation|extracellular matrix organization|collagen catabolic process|extracellular matrix|trans-Golgi network membrane|cell-cell adhesion mediated by cadherin|cadherin binding|regulation of catalytic activity|detection of temperature stimulus involved in sensory perception of pain|extracellular exosome|neuronal stem cell population maintenance|cell-cell adhesion via plasma-membrane adhesion molecules hsa04928 "Parathyroid hormone synthesis, secretion and action" MMP24-AS1-EDEM2 4.483717655 4.161655531 4.80577978 1.154775965 0.207612985 1 1 0.09399065 0.106721905 111089941 MMP24-AS1-EDEM2 readthrough "GO:0004571,GO:0005509,GO:0005783,GO:0005788,GO:0005975,GO:0006986,GO:0016020,GO:0036509,GO:0036510,GO:0036511,GO:0036512,GO:0044322,GO:0097466,GO:1904154,GO:1904382" "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum lumen|carbohydrate metabolic process|response to unfolded protein|membrane|trimming of terminal mannose on B branch|trimming of terminal mannose on C branch|trimming of first mannose on A branch|trimming of second mannose on A branch|endoplasmic reticulum quality control compartment|ubiquitin-dependent glycoprotein ERAD pathway|positive regulation of retrograde protein transport, ER to cytosol|mannose trimming involved in glycoprotein ERAD pathway" hsa04141 Protein processing in endoplasmic reticulum MMP24OS 170.9360764 172.7087045 169.1634483 0.979472625 -0.029922923 0.95471729 1 5.437844327 5.237092587 101410538 MMP24 opposite strand MMP25 6.485287494 6.242483296 6.728091692 1.0777909 0.108077311 1 1 0.062941595 0.066702703 64386 matrix metallopeptidase 25 "GO:0004222,GO:0005515,GO:0005886,GO:0006508,GO:0006954,GO:0008270,GO:0016020,GO:0030198,GO:0030574,GO:0031012,GO:0031225,GO:0035579,GO:0043312,GO:0060022" metalloendopeptidase activity|protein binding|plasma membrane|proteolysis|inflammatory response|zinc ion binding|membrane|extracellular matrix organization|collagen catabolic process|extracellular matrix|anchored component of membrane|specific granule membrane|neutrophil degranulation|hard palate development hsa04928 "Parathyroid hormone synthesis, secretion and action" MMP3 20.61516325 23.9295193 17.30080721 0.722990169 -0.467952065 0.608529082 1 0.700919026 0.498277663 4314 matrix metallopeptidase 3 "GO:0004175,GO:0004222,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0006508,GO:0008233,GO:0008237,GO:0008270,GO:0010727,GO:0019221,GO:0022617,GO:0030198,GO:0030574,GO:0031012,GO:0031334,GO:0071492,GO:0071732,GO:0150077,GO:1903209,GO:1904645" endopeptidase activity|metalloendopeptidase activity|serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|proteolysis|peptidase activity|metallopeptidase activity|zinc ion binding|negative regulation of hydrogen peroxide metabolic process|cytokine-mediated signaling pathway|extracellular matrix disassembly|extracellular matrix organization|collagen catabolic process|extracellular matrix|positive regulation of protein-containing complex assembly|cellular response to UV-A|cellular response to nitric oxide|regulation of neuroinflammatory response|positive regulation of oxidative stress-induced cell death|response to amyloid-beta "hsa04657,hsa04668,hsa05171,hsa05202,hsa05215,hsa05323" IL-17 signaling pathway|TNF signaling pathway|Coronavirus disease - COVID-19|Transcriptional misregulation in cancer|Prostate cancer|Rheumatoid arthritis MMP9 4.885037707 2.080827765 7.689247648 3.695283087 1.88568489 0.299624042 1 0.047538507 0.172728672 4318 matrix metallopeptidase 9 "GO:0001501,GO:0001503,GO:0001934,GO:0004175,GO:0004222,GO:0004252,GO:0005515,GO:0005518,GO:0005576,GO:0005615,GO:0006508,GO:0007566,GO:0008233,GO:0008237,GO:0008270,GO:0019221,GO:0022617,GO:0030198,GO:0030225,GO:0030335,GO:0030574,GO:0034614,GO:0035987,GO:0042802,GO:0043065,GO:0043066,GO:0043312,GO:0043388,GO:0045742,GO:0048013,GO:0050900,GO:0051549,GO:0062023,GO:0070062,GO:0071276,GO:0071492,GO:0090200,GO:0150077,GO:1900122,GO:1904645,GO:1904707,GO:1904724,GO:1904813,GO:2000697,GO:2001243,GO:2001258,GO:2001268" skeletal system development|ossification|positive regulation of protein phosphorylation|endopeptidase activity|metalloendopeptidase activity|serine-type endopeptidase activity|protein binding|collagen binding|extracellular region|extracellular space|proteolysis|embryo implantation|peptidase activity|metallopeptidase activity|zinc ion binding|cytokine-mediated signaling pathway|extracellular matrix disassembly|extracellular matrix organization|macrophage differentiation|positive regulation of cell migration|collagen catabolic process|cellular response to reactive oxygen species|endodermal cell differentiation|identical protein binding|positive regulation of apoptotic process|negative regulation of apoptotic process|neutrophil degranulation|positive regulation of DNA binding|positive regulation of epidermal growth factor receptor signaling pathway|ephrin receptor signaling pathway|leukocyte migration|positive regulation of keratinocyte migration|collagen-containing extracellular matrix|extracellular exosome|cellular response to cadmium ion|cellular response to UV-A|positive regulation of release of cytochrome c from mitochondria|regulation of neuroinflammatory response|positive regulation of receptor binding|response to amyloid-beta|positive regulation of vascular associated smooth muscle cell proliferation|tertiary granule lumen|ficolin-1-rich granule lumen|negative regulation of epithelial cell differentiation involved in kidney development|negative regulation of intrinsic apoptotic signaling pathway|negative regulation of cation channel activity|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway "hsa01522,hsa04657,hsa04668,hsa04670,hsa04915,hsa04926,hsa05161,hsa05200,hsa05202,hsa05205,hsa05206,hsa05215,hsa05219,hsa05418" Endocrine resistance|IL-17 signaling pathway|TNF signaling pathway|Leukocyte transendothelial migration|Estrogen signaling pathway|Relaxin signaling pathway|Hepatitis B|Pathways in cancer|Transcriptional misregulation in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Prostate cancer|Bladder cancer|Fluid shear stress and atherosclerosis MMRN2 69.81717057 66.58648849 73.04785266 1.097037166 0.133612404 0.825789569 1 0.842284548 0.908555274 79812 multimerin 2 "GO:0002042,GO:0005201,GO:0005515,GO:0005604,GO:0005615,GO:0030948,GO:0062023,GO:0070062,GO:0090051" cell migration involved in sprouting angiogenesis|extracellular matrix structural constituent|protein binding|basement membrane|extracellular space|negative regulation of vascular endothelial growth factor receptor signaling pathway|collagen-containing extracellular matrix|extracellular exosome|negative regulation of cell migration involved in sprouting angiogenesis MMS19 4343.517833 4139.806839 4547.228828 1.0984157 0.135424152 0.570896858 1 52.21788758 56.39715671 64210 "MMS19 homolog, cytosolic iron-sulfur assembly component" "GO:0000160,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005675,GO:0005737,GO:0005815,GO:0005819,GO:0005829,GO:0006259,GO:0006281,GO:0006289,GO:0006351,GO:0006974,GO:0007059,GO:0009725,GO:0016020,GO:0016226,GO:0019899,GO:0030159,GO:0030331,GO:0030674,GO:0045893,GO:0071817,GO:0097361,GO:0097428,GO:1905168" "phosphorelay signal transduction system|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription factor TFIIH holo complex|cytoplasm|microtubule organizing center|spindle|cytosol|DNA metabolic process|DNA repair|nucleotide-excision repair|transcription, DNA-templated|cellular response to DNA damage stimulus|chromosome segregation|response to hormone|membrane|iron-sulfur cluster assembly|enzyme binding|signaling receptor complex adaptor activity|estrogen receptor binding|protein-macromolecule adaptor activity|positive regulation of transcription, DNA-templated|MMXD complex|CIA complex|protein maturation by iron-sulfur cluster transfer|positive regulation of double-strand break repair via homologous recombination" MMS22L 757.3067203 805.2803452 709.3330955 0.880852364 -0.18302786 0.471771666 1 3.438931902 2.978501881 253714 "MMS22 like, DNA repair protein" "GO:0000724,GO:0005515,GO:0005654,GO:0005829,GO:0031297,GO:0035101,GO:0042555,GO:0043596" double-strand break repair via homologous recombination|protein binding|nucleoplasm|cytosol|replication fork processing|FACT complex|MCM complex|nuclear replication fork MMUT 678.8944808 601.3592242 756.4297374 1.257866691 0.330979033 0.198755398 1 8.322986655 10.29401967 4594 methylmalonyl-CoA mutase "GO:0003924,GO:0004494,GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0009235,GO:0009791,GO:0019626,GO:0031419,GO:0042802,GO:0042803,GO:0043547,GO:0046872,GO:0050667,GO:0072341" GTPase activity|methylmalonyl-CoA mutase activity|protein binding|cytoplasm|mitochondrion|mitochondrial matrix|cobalamin metabolic process|post-embryonic development|short-chain fatty acid catabolic process|cobalamin binding|identical protein binding|protein homodimerization activity|positive regulation of GTPase activity|metal ion binding|homocysteine metabolic process|modified amino acid binding "hsa00280,hsa00630,hsa00640" "Valine, leucine and isoleucine degradation|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism" MN1 13.12909084 16.64662212 9.61155956 0.577387982 -0.792387015 0.459078304 1 0.113693323 0.064546676 4330 "MN1 proto-oncogene, transcriptional regulator" "GO:0001957,GO:0003674,GO:0005515,GO:0005634,GO:0006355,GO:0007275,GO:0033689,GO:0070564,GO:1902806" "intramembranous ossification|molecular_function|protein binding|nucleus|regulation of transcription, DNA-templated|multicellular organism development|negative regulation of osteoblast proliferation|positive regulation of vitamin D receptor signaling pathway|regulation of cell cycle G1/S phase transition" MNAT1 1072.818125 874.9880753 1270.648174 1.452189132 0.538229361 0.027737136 0.877967194 13.31522823 19.01266412 4331 MNAT1 component of CDK activating kinase "GO:0000079,GO:0000082,GO:0000086,GO:0000439,GO:0005515,GO:0005654,GO:0005675,GO:0006281,GO:0006283,GO:0006294,GO:0006357,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0007512,GO:0008270,GO:0019907,GO:0021591,GO:0043066,GO:0045737,GO:0047485,GO:0048661,GO:0051592,GO:0061575,GO:0065003,GO:0070516,GO:0070985,GO:1905775" "regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|transcription factor TFIIH core complex|protein binding|nucleoplasm|transcription factor TFIIH holo complex|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|adult heart development|zinc ion binding|cyclin-dependent protein kinase activating kinase holoenzyme complex|ventricular system development|negative regulation of apoptotic process|positive regulation of cyclin-dependent protein serine/threonine kinase activity|protein N-terminus binding|positive regulation of smooth muscle cell proliferation|response to calcium ion|cyclin-dependent protein serine/threonine kinase activator activity|protein-containing complex assembly|CAK-ERCC2 complex|transcription factor TFIIK complex|negative regulation of DNA helicase activity" "hsa03022,hsa03420" Basal transcription factors|Nucleotide excision repair MND1 344.7952496 346.4578229 343.1326763 0.990402449 -0.013913213 0.973946701 1 13.12265241 12.77922479 84057 meiotic nuclear divisions 1 "GO:0003690,GO:0005634,GO:0007131" double-stranded DNA binding|nucleus|reciprocal meiotic recombination MNS1 68.33580767 65.54607461 71.12554074 1.085122811 0.117858332 0.85152254 1 1.723188933 1.83858185 55329 meiosis specific nuclear structural 1 "GO:0005515,GO:0005635,GO:0005882,GO:0005930,GO:0007283,GO:0031514,GO:0036126,GO:0042802,GO:0044782,GO:0045724,GO:0051321,GO:0070986" protein binding|nuclear envelope|intermediate filament|axoneme|spermatogenesis|motile cilium|sperm flagellum|identical protein binding|cilium organization|positive regulation of cilium assembly|meiotic cell cycle|left/right axis specification MNT 551.987296 587.8338437 516.1407484 0.878038503 -0.187643889 0.485225342 1 3.417759216 2.950707785 4335 MAX network transcriptional repressor "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0003682,GO:0003700,GO:0005515,GO:0005654,GO:0006357,GO:0006366,GO:0007275,GO:0007569,GO:0008285,GO:0046983,GO:0051726,GO:2001234" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|multicellular organism development|cell aging|negative regulation of cell population proliferation|protein dimerization activity|regulation of cell cycle|negative regulation of apoptotic signaling pathway" bHLH MNX1 54.0077871 42.65696919 65.35860501 1.532190548 0.615595727 0.295636833 1 0.867908519 1.307548807 3110 motor neuron and pancreas homeobox 1 "GO:0000785,GO:0000981,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0007417,GO:0021520,GO:0031018,GO:0048812,GO:1990837" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|central nervous system development|spinal cord motor neuron cell fate specification|endocrine pancreas development|neuron projection morphogenesis|sequence-specific double-stranded DNA binding" hsa04950 Maturity onset diabetes of the young MOAP1 735.8398416 708.5218541 763.1578291 1.077112618 0.107169099 0.677092989 1 15.70939308 16.63763908 64112 modulator of apoptosis 1 "GO:0001844,GO:0005515,GO:0005737,GO:0005739,GO:0005741,GO:0005829,GO:0008625,GO:0008630,GO:0031625,GO:0042981,GO:0043065,GO:0090200,GO:0097190,GO:0097192" protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|protein binding|cytoplasm|mitochondrion|mitochondrial outer membrane|cytosol|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|ubiquitin protein ligase binding|regulation of apoptotic process|positive regulation of apoptotic process|positive regulation of release of cytochrome c from mitochondria|apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand MOB1A 3358.807182 3559.255893 3158.358471 0.887364822 -0.172400734 0.467490126 1 37.51746896 32.73459095 55233 MOB kinase activator 1A "GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0035329,GO:0046872,GO:0070062" protein binding|nucleoplasm|nucleolus|cytosol|hippo signaling|metal ion binding|extracellular exosome "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species MOB1B 1159.662501 1123.646993 1195.678009 1.064104667 0.089640063 0.71445933 1 8.016975248 8.388147703 92597 MOB kinase activator 1B "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0019209,GO:0019900,GO:0031952,GO:0033674,GO:0035329,GO:0046872,GO:0070062" protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|kinase activator activity|kinase binding|regulation of protein autophosphorylation|positive regulation of kinase activity|hippo signaling|metal ion binding|extracellular exosome "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species MOB2 330.6358057 302.7604398 358.5111716 1.184141402 0.243841367 0.4276956 1 9.211954518 10.72572183 81532 MOB kinase activator 2 "GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0046872,GO:0048471" protein binding|nucleoplasm|nucleolus|cytosol|metal ion binding|perinuclear region of cytoplasm MOB3A 980.0558996 1000.878155 959.2336441 0.958392027 -0.061312188 0.806937405 1 14.52679565 13.68939321 126308 MOB kinase activator 3A GO:0046872 metal ion binding MOB3B 304.8034818 305.8816815 303.7252821 0.992950217 -0.010206707 0.985858196 1 2.516470349 2.456916921 79817 MOB kinase activator 3B "GO:0005515,GO:0035330,GO:0046872" protein binding|regulation of hippo signaling|metal ion binding MOB3C 497.7819785 439.0546585 556.5092985 1.267517125 0.342005239 0.211675755 1 7.849762203 9.783213131 148932 MOB kinase activator 3C "GO:0005515,GO:0046872" protein binding|metal ion binding MOCOS 1388.022673 1706.278768 1069.766579 0.626958853 -0.673557332 0.005036442 0.430157521 14.73001647 9.080577101 55034 molybdenum cofactor sulfurase "GO:0005515,GO:0005575,GO:0005829,GO:0006777,GO:0008265,GO:0016829,GO:0030151,GO:0030170,GO:0032324,GO:0043545,GO:0102867" protein binding|cellular_component|cytosol|Mo-molybdopterin cofactor biosynthetic process|Mo-molybdopterin cofactor sulfurase activity|lyase activity|molybdenum ion binding|pyridoxal phosphate binding|molybdopterin cofactor biosynthetic process|molybdopterin cofactor metabolic process|molybdenum cofactor sulfurtransferase activity hsa00790 Folate biosynthesis MOCS1 143.5978519 136.2942186 150.9014851 1.107174513 0.146882637 0.734553765 1 1.575432521 1.715090591 4337 molybdenum cofactor synthesis 1 "GO:0005525,GO:0005634,GO:0005829,GO:0006777,GO:0019008,GO:0032324,GO:0046872,GO:0051539,GO:0061798,GO:0061799" "GTP binding|nucleus|cytosol|Mo-molybdopterin cofactor biosynthetic process|molybdopterin synthase complex|molybdopterin cofactor biosynthetic process|metal ion binding|4 iron, 4 sulfur cluster binding|GTP 3',8'-cyclase activity|cyclic pyranopterin monophosphate synthase activity" hsa00790 Folate biosynthesis MOCS2 1052.984865 997.7569135 1108.212817 1.110704223 0.151474683 0.537569814 1 12.78167371 13.9590971 4338 molybdenum cofactor synthesis 2 "GO:0005654,GO:0005829,GO:0006777,GO:0016607,GO:0019008,GO:0030366,GO:0032324" nucleoplasm|cytosol|Mo-molybdopterin cofactor biosynthetic process|nuclear speck|molybdopterin synthase complex|molybdopterin synthase activity|molybdopterin cofactor biosynthetic process "hsa00790,hsa04122" Folate biosynthesis|Sulfur relay system MOCS3 204.6306407 237.2143652 172.0469161 0.725280343 -0.463389347 0.198665443 1 2.476466098 1.766076341 27304 molybdenum cofactor synthesis 3 "GO:0002098,GO:0002143,GO:0004792,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006777,GO:0016779,GO:0016783,GO:0018215,GO:0032324,GO:0032447,GO:0034227,GO:0042292,GO:0046872,GO:0061604,GO:0061605" tRNA wobble uridine modification|tRNA wobble position uridine thiolation|thiosulfate sulfurtransferase activity|protein binding|ATP binding|cytoplasm|cytosol|Mo-molybdopterin cofactor biosynthetic process|nucleotidyltransferase activity|sulfurtransferase activity|protein phosphopantetheinylation|molybdopterin cofactor biosynthetic process|protein urmylation|tRNA thio-modification|URM1 activating enzyme activity|metal ion binding|molybdopterin-synthase sulfurtransferase activity|molybdopterin-synthase adenylyltransferase activity hsa04122 Sulfur relay system MOGS 999.6061113 984.231533 1014.98069 1.031241792 0.044382636 0.860587834 1 18.32111195 18.57733924 7841 mannosyl-oligosaccharide glucosidase "GO:0004573,GO:0005783,GO:0005789,GO:0006457,GO:0006487,GO:0009311,GO:0015926,GO:0016020,GO:0016021,GO:0070062" mannosyl-oligosaccharide glucosidase activity|endoplasmic reticulum|endoplasmic reticulum membrane|protein folding|protein N-linked glycosylation|oligosaccharide metabolic process|glucosidase activity|membrane|integral component of membrane|extracellular exosome "hsa00510,hsa04141" N-Glycan biosynthesis|Protein processing in endoplasmic reticulum MOK 297.4910165 265.3055401 329.6764929 1.242629509 0.313396219 0.322287842 1 3.371159301 4.119003076 5891 MOK protein kinase "GO:0000165,GO:0004672,GO:0004674,GO:0004693,GO:0004707,GO:0005524,GO:0005634,GO:0005737,GO:0005929,GO:0006468,GO:0007165,GO:0010468,GO:0035556,GO:0046872,GO:0051726,GO:0097546" MAPK cascade|protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|MAP kinase activity|ATP binding|nucleus|cytoplasm|cilium|protein phosphorylation|signal transduction|regulation of gene expression|intracellular signal transduction|metal ion binding|regulation of cell cycle|ciliary base MON1A 96.352755 107.1626299 85.54288008 0.7982529 -0.325082206 0.501147669 1 2.378981948 1.867251556 84315 "MON1 homolog A, secretory trafficking associated" "GO:0005085,GO:0005515,GO:0005829,GO:0006623,GO:0009306,GO:0016192,GO:0035658,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|cytosol|protein targeting to vacuole|protein secretion|vesicle-mediated transport|Mon1-Ccz1 complex|regulation of catalytic activity MON1B 2028.82942 2014.241277 2043.417562 1.014485 0.020747534 0.932295899 1 18.4924058 18.44634062 22879 "MON1 homolog B, secretory trafficking associated" "GO:0005515,GO:0005737,GO:0006623,GO:0016192,GO:0019085,GO:0019086,GO:0035658" protein binding|cytoplasm|protein targeting to vacuole|vesicle-mediated transport|early viral transcription|late viral transcription|Mon1-Ccz1 complex MON2 1511.20535 1521.085096 1501.325603 0.987009607 -0.018863968 0.939909231 1 6.778915738 6.578892562 23041 "MON2 homolog, regulator of endosome-to-Golgi trafficking" "GO:0005515,GO:0005829,GO:0006895,GO:0015031,GO:0070062" protein binding|cytosol|Golgi to endosome transport|protein transport|extracellular exosome MORC2 1138.476827 1223.526726 1053.426928 0.860975821 -0.215955372 0.375009641 1 10.79117049 9.135465627 22880 MORC family CW-type zinc finger 2 "GO:0000287,GO:0000792,GO:0003682,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006338,GO:0006631,GO:0006974,GO:0008270,GO:0016363,GO:0016887,GO:0042803,GO:0045814,GO:0045869,GO:0090309" "magnesium ion binding|heterochromatin|chromatin binding|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|chromatin remodeling|fatty acid metabolic process|cellular response to DNA damage stimulus|zinc ion binding|nuclear matrix|ATPase activity|protein homodimerization activity|negative regulation of gene expression, epigenetic|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|positive regulation of DNA methylation-dependent heterochromatin assembly" MORC3 892.6265349 812.5632423 972.6898275 1.197063535 0.259499727 0.296975903 1 9.058910971 10.6626308 23515 MORC family CW-type zinc finger 3 "GO:0003723,GO:0005515,GO:0005654,GO:0006468,GO:0007569,GO:0008270,GO:0009791,GO:0016032,GO:0016363,GO:0016605,GO:0018105,GO:0035064,GO:0048147,GO:0050821,GO:0051457" RNA binding|protein binding|nucleoplasm|protein phosphorylation|cell aging|zinc ion binding|post-embryonic development|viral process|nuclear matrix|PML body|peptidyl-serine phosphorylation|methylated histone binding|negative regulation of fibroblast proliferation|protein stabilization|maintenance of protein location in nucleus MORC4 1924.16783 1953.897272 1894.438389 0.969569085 -0.044584397 0.852618402 1 24.61078741 23.46256274 79710 MORC family CW-type zinc finger 4 "GO:0005515,GO:0005654,GO:0008270,GO:0035064" protein binding|nucleoplasm|zinc ion binding|methylated histone binding MORF4L1 4311.645587 4224.080364 4399.210811 1.041460018 0.058607455 0.806796207 1 98.48466818 100.8515103 10933 mortality factor 4 like 1 "GO:0000123,GO:0000724,GO:0005515,GO:0005654,GO:0006342,GO:0016573,GO:0016575,GO:0016580,GO:0016607,GO:0035267,GO:0040008,GO:0043967,GO:0043968,GO:0047485" histone acetyltransferase complex|double-strand break repair via homologous recombination|protein binding|nucleoplasm|chromatin silencing|histone acetylation|histone deacetylation|Sin3 complex|nuclear speck|NuA4 histone acetyltransferase complex|regulation of growth|histone H4 acetylation|histone H2A acetylation|protein N-terminus binding MORF4L2 11415.08604 11138.67103 11691.50105 1.049631596 0.069883054 0.783864328 1 301.1400206 310.796808 9643 mortality factor 4 like 2 "GO:0000123,GO:0005515,GO:0005654,GO:0005730,GO:0005886,GO:0006281,GO:0006342,GO:0016573,GO:0016575,GO:0035267,GO:0040008,GO:0043967,GO:0043968,GO:0045944,GO:0051155" histone acetyltransferase complex|protein binding|nucleoplasm|nucleolus|plasma membrane|DNA repair|chromatin silencing|histone acetylation|histone deacetylation|NuA4 histone acetyltransferase complex|regulation of growth|histone H4 acetylation|histone H2A acetylation|positive regulation of transcription by RNA polymerase II|positive regulation of striated muscle cell differentiation MORN1 43.59358744 46.81862472 40.36855015 0.86223272 -0.213850783 0.763080886 1 1.278068518 1.083552143 79906 MORN repeat containing 1 MORN2 116.175339 110.2838716 122.0668064 1.106841868 0.146449122 0.757062076 1 8.095801282 8.810825433 729967 MORN repeat containing 2 "GO:0001669,GO:0005515,GO:0005634,GO:0007283,GO:0030154" acrosomal vesicle|protein binding|nucleus|spermatogenesis|cell differentiation MORN3 39.63007672 43.69738307 35.56277037 0.813842108 -0.297179167 0.673939417 1 0.58155836 0.465376703 283385 MORN repeat containing 3 "GO:0005515,GO:0005634" protein binding|nucleus MORN4 757.2576449 728.2897178 786.225572 1.079550559 0.110430811 0.666347144 1 15.0824539 16.00980978 118812 MORN repeat containing 4 "GO:0005515,GO:0005737,GO:0032426,GO:0032433,GO:0048678" protein binding|cytoplasm|stereocilium tip|filopodium tip|response to axon injury MOSMO 2022.875629 1782.228981 2263.522276 1.270051324 0.344886799 0.144986418 1 21.28312489 26.57833943 730094 modulator of smoothened "GO:0005794,GO:0005886,GO:0016021,GO:0030154,GO:0031647,GO:0045664,GO:0045879,GO:0060170" Golgi apparatus|plasma membrane|integral component of membrane|cell differentiation|regulation of protein stability|regulation of neuron differentiation|negative regulation of smoothened signaling pathway|ciliary membrane hsa04340 Hedgehog signaling pathway MOSPD1 472.8510599 491.0753526 454.6267672 0.925778019 -0.111261786 0.6931439 1 9.72820676 8.855454093 56180 motile sperm domain containing 1 "GO:0000122,GO:0000139,GO:0005515,GO:0005634,GO:0005737,GO:0005789,GO:0016021,GO:0030154,GO:0045944,GO:0048471" negative regulation of transcription by RNA polymerase II|Golgi membrane|protein binding|nucleus|cytoplasm|endoplasmic reticulum membrane|integral component of membrane|cell differentiation|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm MOSPD2 1238.333251 1182.950585 1293.715917 1.093634792 0.129131046 0.594588406 1 14.51308012 15.60641278 158747 motile sperm domain containing 2 "GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0006935,GO:0016020,GO:0035579,GO:0043312,GO:0044232,GO:0090023,GO:0090026,GO:0140284" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|chemotaxis|membrane|specific granule membrane|neutrophil degranulation|organelle membrane contact site|positive regulation of neutrophil chemotaxis|positive regulation of monocyte chemotaxis|endoplasmic reticulum-endosome membrane contact site MOSPD3 437.5266777 396.3976893 478.6556661 1.207513765 0.272039635 0.336861216 1 17.46904718 20.74113347 64598 motile sperm domain containing 3 "GO:0005515,GO:0005789,GO:0005886,GO:0007507,GO:0016021,GO:0033149,GO:0061817,GO:0090158" protein binding|endoplasmic reticulum membrane|plasma membrane|heart development|integral component of membrane|FFAT motif binding|endoplasmic reticulum-plasma membrane tethering|endoplasmic reticulum membrane organization MOV10 1882.99161 1970.543894 1795.439326 0.911138966 -0.134256986 0.57175392 1 19.77144311 17.71308343 4343 Mov10 RISC complex RNA helicase "GO:0000932,GO:0003723,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005829,GO:0007223,GO:0010494,GO:0010526,GO:0010628,GO:0010629,GO:0016032,GO:0032574,GO:0035194,GO:0035195,GO:0035279,GO:0036464,GO:0043186,GO:0045652,GO:0051607,GO:0061014,GO:0061158,GO:0150011" "P-body|RNA binding|protein binding|ATP binding|extracellular space|nucleus|cytosol|Wnt signaling pathway, calcium modulating pathway|cytoplasmic stress granule|negative regulation of transposition, RNA-mediated|positive regulation of gene expression|negative regulation of gene expression|viral process|5'-3' RNA helicase activity|post-transcriptional gene silencing by RNA|gene silencing by miRNA|mRNA cleavage involved in gene silencing by miRNA|cytoplasmic ribonucleoprotein granule|P granule|regulation of megakaryocyte differentiation|defense response to virus|positive regulation of mRNA catabolic process|3'-UTR-mediated mRNA destabilization|regulation of neuron projection arborization" MOV10L1 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.008021522 0.021859335 54456 Mov10 like RISC complex RNA helicase 1 "GO:0000287,GO:0003723,GO:0003724,GO:0005524,GO:0005829,GO:0007141,GO:0007275,GO:0007281,GO:0007283,GO:0034587,GO:0035194,GO:0043046,GO:0043186,GO:0071546" magnesium ion binding|RNA binding|RNA helicase activity|ATP binding|cytosol|male meiosis I|multicellular organism development|germ cell development|spermatogenesis|piRNA metabolic process|post-transcriptional gene silencing by RNA|DNA methylation involved in gamete generation|P granule|pi-body MOXD1 1277.527409 1215.203415 1339.851403 1.102573764 0.140875177 0.560245588 1 21.37546895 23.17365217 26002 monooxygenase DBH like 1 "GO:0004500,GO:0005507,GO:0005515,GO:0005615,GO:0005789,GO:0006589,GO:0016021,GO:0030667,GO:0042420,GO:0042421,GO:0055114" dopamine beta-monooxygenase activity|copper ion binding|protein binding|extracellular space|endoplasmic reticulum membrane|octopamine biosynthetic process|integral component of membrane|secretory granule membrane|dopamine catabolic process|norepinephrine biosynthetic process|oxidation-reduction process MPC1 168.4142996 169.5874629 167.2411363 0.986164505 -0.020099768 0.975808671 1 2.315316246 2.245075055 51660 mitochondrial pyruvate carrier 1 "GO:0003674,GO:0005515,GO:0005739,GO:0006850,GO:0008150,GO:0031305,GO:0050833" molecular_function|protein binding|mitochondrion|mitochondrial pyruvate transmembrane transport|biological_process|integral component of mitochondrial inner membrane|pyruvate transmembrane transporter activity MPC2 514.8890569 522.2877691 507.4903448 0.971668063 -0.041464545 0.885691867 1 11.2212312 10.72085983 25874 mitochondrial pyruvate carrier 2 "GO:0005515,GO:0005634,GO:0005739,GO:0006850,GO:0031305,GO:0035774,GO:0042802,GO:0050833,GO:0061732" protein binding|nucleus|mitochondrion|mitochondrial pyruvate transmembrane transport|integral component of mitochondrial inner membrane|positive regulation of insulin secretion involved in cellular response to glucose stimulus|identical protein binding|pyruvate transmembrane transporter activity|mitochondrial acetyl-CoA biosynthetic process from pyruvate MPDU1 702.0509281 679.3902654 724.7115908 1.066708824 0.093166422 0.72010986 1 21.97443018 23.04807658 9526 mannose-P-dolichol utilization defect 1 "GO:0005515,GO:0005789,GO:0006457,GO:0006488,GO:0009312,GO:0016020,GO:0016021" protein binding|endoplasmic reticulum membrane|protein folding|dolichol-linked oligosaccharide biosynthetic process|oligosaccharide biosynthetic process|membrane|integral component of membrane MPDZ 961.8977321 1041.454297 882.3411676 0.847220248 -0.239191025 0.332784485 1 6.117158452 5.095857036 8777 multiple PDZ domain crumbs cell polarity complex component "GO:0005515,GO:0005737,GO:0005923,GO:0008022,GO:0014069,GO:0016032,GO:0016324,GO:0016327,GO:0030425" protein binding|cytoplasm|bicellular tight junction|protein C-terminus binding|postsynaptic density|viral process|apical plasma membrane|apicolateral plasma membrane|dendrite hsa04530 Tight junction MPG 1181.605542 1131.970304 1231.24078 1.087697067 0.121276809 0.618781816 1 35.68291475 38.16273207 4350 N-methylpurine DNA glycosylase "GO:0003684,GO:0003905,GO:0005515,GO:0005654,GO:0005829,GO:0006284,GO:0006307,GO:0008725,GO:0019104,GO:0042645,GO:0043916,GO:0045007,GO:0052821,GO:0052822" damaged DNA binding|alkylbase DNA N-glycosylase activity|protein binding|nucleoplasm|cytosol|base-excision repair|DNA dealkylation involved in DNA repair|DNA-3-methyladenine glycosylase activity|DNA N-glycosylase activity|mitochondrial nucleoid|DNA-7-methylguanine glycosylase activity|depurination|DNA-7-methyladenine glycosylase activity|DNA-3-methylguanine glycosylase activity hsa03410 Base excision repair MPHOSPH10 316.0549201 311.0837509 321.0260893 1.031960327 0.045387508 0.893788144 1 7.671889112 7.784603498 10199 M-phase phosphoprotein 10 "GO:0000375,GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0005732,GO:0006364,GO:0006396,GO:0008380,GO:0010923,GO:0032040,GO:0034457" "RNA splicing, via transesterification reactions|RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|sno(s)RNA-containing ribonucleoprotein complex|rRNA processing|RNA processing|RNA splicing|negative regulation of phosphatase activity|small-subunit processome|Mpp10 complex" hsa03008 Ribosome biogenesis in eukaryotes MPHOSPH6 236.918684 214.3252598 259.5121081 1.21083305 0.27599996 0.422495254 1 8.264555783 9.839543741 10200 M-phase phosphoprotein 6 "GO:0000176,GO:0000178,GO:0000460,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006364" nuclear exosome (RNase complex)|exosome (RNase complex)|maturation of 5.8S rRNA|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|rRNA processing hsa03018 RNA degradation MPHOSPH8 732.0392627 797.997448 666.0810775 0.834690736 -0.260686335 0.306344992 1 9.734321632 7.989184742 54737 M-phase phosphoprotein 8 "GO:0000786,GO:0000792,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0035064,GO:0044030,GO:0045814,GO:0045869,GO:0045892,GO:0090309" "nucleosome|heterochromatin|chromatin binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|methylated histone binding|regulation of DNA methylation|negative regulation of gene expression, epigenetic|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|negative regulation of transcription, DNA-templated|positive regulation of DNA methylation-dependent heterochromatin assembly" MPHOSPH9 1124.010412 1146.536099 1101.484726 0.960706538 -0.05783229 0.815336235 1 7.23610742 6.835447153 10198 M-phase phosphoprotein 9 "GO:0000139,GO:0005794,GO:0005814,GO:0016020" Golgi membrane|Golgi apparatus|centriole|membrane MPI 675.0442121 714.7643374 635.3240869 0.888858122 -0.169974937 0.511659228 1 20.18288836 17.63952726 4351 mannose phosphate isomerase "GO:0000032,GO:0004476,GO:0005829,GO:0006486,GO:0008270,GO:0009298,GO:0061611,GO:0070062" cell wall mannoprotein biosynthetic process|mannose-6-phosphate isomerase activity|cytosol|protein glycosylation|zinc ion binding|GDP-mannose biosynthetic process|mannose to fructose-6-phosphate metabolic process|extracellular exosome "hsa00051,hsa00520" Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism MPLKIP 531.0009952 491.0753526 570.9266379 1.162604954 0.217360962 0.42216611 1 3.436185789 3.928076935 136647 M-phase specific PLK1 interacting protein "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005813,GO:0007049,GO:0030496,GO:0043231,GO:0051301" protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|centrosome|cell cycle|midbody|intracellular membrane-bounded organelle|cell division MPND 206.8454466 207.0423626 206.6485305 0.998097819 -0.002746881 1 1 6.82066072 6.693769171 84954 MPN domain containing "GO:0003713,GO:0004843,GO:0005515,GO:0006338,GO:0006508,GO:0008237,GO:0018215,GO:0042393,GO:0045944,GO:0046872,GO:0070122" transcription coactivator activity|thiol-dependent ubiquitin-specific protease activity|protein binding|chromatin remodeling|proteolysis|metallopeptidase activity|protein phosphopantetheinylation|histone binding|positive regulation of transcription by RNA polymerase II|metal ion binding|isopeptidase activity MPP1 1501.688754 1384.790878 1618.58663 1.168831089 0.225066457 0.346000129 1 34.42186493 39.56009532 4354 membrane palmitoylated protein 1 "GO:0004385,GO:0005515,GO:0005886,GO:0007165,GO:0016020,GO:0030863,GO:0032420,GO:0034451,GO:0046037,GO:0046710,GO:0090022" guanylate kinase activity|protein binding|plasma membrane|signal transduction|membrane|cortical cytoskeleton|stereocilium|centriolar satellite|GMP metabolic process|GDP metabolic process|regulation of neutrophil chemotaxis MPP2 706.7925412 639.8545378 773.7305446 1.209228815 0.274087263 0.284657374 1 5.679005601 6.752303634 4355 membrane palmitoylated protein 2 "GO:0005515,GO:0005737,GO:0005856,GO:0014069,GO:0032590,GO:0043197,GO:0043198,GO:0051260,GO:0060079,GO:0060291" protein binding|cytoplasm|cytoskeleton|postsynaptic density|dendrite membrane|dendritic spine|dendritic shaft|protein homooligomerization|excitatory postsynaptic potential|long-term synaptic potentiation MPP3 138.2272058 146.6983575 129.7560541 0.88450925 -0.177050865 0.683440767 1 2.291868184 1.993256519 4356 membrane palmitoylated protein 3 GO:0005515 protein binding MPP4 39.19415812 32.25283036 46.13548589 1.430432163 0.51645108 0.443713718 1 0.427433394 0.601183281 58538 membrane palmitoylated protein 4 "GO:0005515,GO:0005829,GO:0005912,GO:0008150,GO:0015629,GO:0032991,GO:0035418" protein binding|cytosol|adherens junction|biological_process|actin cytoskeleton|protein-containing complex|protein localization to synapse hsa04530 Tight junction MPP7 229.9131895 207.0423626 252.7840164 1.22092896 0.287979259 0.407483011 1 1.709914944 2.052750098 143098 membrane palmitoylated protein 7 "GO:0005515,GO:0005654,GO:0005912,GO:0005923,GO:0005938,GO:0016328,GO:0019904,GO:0030010,GO:0030054,GO:0031334,GO:0035591,GO:0045296,GO:0060090,GO:0070830,GO:0071896,GO:0097025" protein binding|nucleoplasm|adherens junction|bicellular tight junction|cell cortex|lateral plasma membrane|protein domain specific binding|establishment of cell polarity|cell junction|positive regulation of protein-containing complex assembly|signaling adaptor activity|cadherin binding|molecular adaptor activity|bicellular tight junction assembly|protein localization to adherens junction|MPP7-DLG1-LIN7 complex MPPE1 295.1868918 318.3666481 272.0071355 0.854383263 -0.22704471 0.476495228 1 3.453382698 2.901139548 65258 metallophosphoesterase 1 "GO:0005515,GO:0005654,GO:0005793,GO:0005794,GO:0005801,GO:0006506,GO:0006888,GO:0016021,GO:0030145,GO:0033116,GO:0034235,GO:0062050,GO:0070971" protein binding|nucleoplasm|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|GPI anchor biosynthetic process|endoplasmic reticulum to Golgi vesicle-mediated transport|integral component of membrane|manganese ion binding|endoplasmic reticulum-Golgi intermediate compartment membrane|GPI anchor binding|GPI-mannose ethanolamine phosphate phosphodiesterase activity|endoplasmic reticulum exit site MPRIP 7764.876223 7410.868086 8118.88436 1.095537563 0.131638951 0.592949024 1 26.14041039 28.15858666 23164 myosin phosphatase Rho interacting protein "GO:0005515,GO:0005829,GO:0005925,GO:0007015,GO:0015629,GO:0045296,GO:0051015" protein binding|cytosol|focal adhesion|actin filament organization|actin cytoskeleton|cadherin binding|actin filament binding MPST 978.4361425 945.7362193 1011.136066 1.069152312 0.096467395 0.698172512 1 36.6537428 38.5326685 4357 mercaptopyruvate sulfurtransferase "GO:0000098,GO:0001822,GO:0001889,GO:0004792,GO:0005515,GO:0005739,GO:0005759,GO:0005829,GO:0009440,GO:0009636,GO:0016784,GO:0019346,GO:0021510,GO:0042802,GO:0043005,GO:0045202,GO:0070062,GO:0070814" sulfur amino acid catabolic process|kidney development|liver development|thiosulfate sulfurtransferase activity|protein binding|mitochondrion|mitochondrial matrix|cytosol|cyanate catabolic process|response to toxic substance|3-mercaptopyruvate sulfurtransferase activity|transsulfuration|spinal cord development|identical protein binding|neuron projection|synapse|extracellular exosome|hydrogen sulfide biosynthetic process "hsa00270,hsa00920,hsa04122" Cysteine and methionine metabolism|Sulfur metabolism|Sulfur relay system MPV17 689.0747083 780.310412 597.8390046 0.76615536 -0.384291125 0.134416018 1 35.11275931 26.45166308 4358 mitochondrial inner membrane protein MPV17 "GO:0000002,GO:0005737,GO:0005739,GO:0005743,GO:0005777,GO:0005778,GO:0005829,GO:0006625,GO:0015267,GO:0016021,GO:0032836,GO:0034614,GO:0042592,GO:0048839,GO:0055085,GO:1901858,GO:2000377" mitochondrial genome maintenance|cytoplasm|mitochondrion|mitochondrial inner membrane|peroxisome|peroxisomal membrane|cytosol|protein targeting to peroxisome|channel activity|integral component of membrane|glomerular basement membrane development|cellular response to reactive oxygen species|homeostatic process|inner ear development|transmembrane transport|regulation of mitochondrial DNA metabolic process|regulation of reactive oxygen species metabolic process hsa04146 Peroxisome MPV17L2 253.4514496 232.0122958 274.8906034 1.184810496 0.244656327 0.467383672 1 7.846685556 9.14126546 84769 MPV17 mitochondrial inner membrane protein like 2 "GO:0005737,GO:0005739,GO:0005743,GO:0005762,GO:0016021,GO:0061668,GO:0070131" cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|integral component of membrane|mitochondrial ribosome assembly|positive regulation of mitochondrial translation hsa04146 Peroxisome MPZ 32.86738648 30.1720026 35.56277037 1.178667881 0.237157261 0.770361225 1 0.596600343 0.691426668 4359 myelin protein zero "GO:0005198,GO:0005886,GO:0005887,GO:0007268,GO:0042552,GO:0043209,GO:0045202,GO:0098742,GO:0098743" structural molecule activity|plasma membrane|integral component of plasma membrane|chemical synaptic transmission|myelination|myelin sheath|synapse|cell-cell adhesion via plasma-membrane adhesion molecules|cell aggregation hsa04514 Cell adhesion molecules MPZL1 2204.698995 2366.941583 2042.456406 0.862909512 -0.212718814 0.368437528 1 25.37551668 21.53036185 9019 myelin protein zero like 1 "GO:0005198,GO:0005515,GO:0005887,GO:0005925,GO:0007169,GO:0007267,GO:0009986" structural molecule activity|protein binding|integral component of plasma membrane|focal adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|cell-cell signaling|cell surface hsa04514 Cell adhesion molecules MPZL2 14.37267996 11.44455271 17.30080721 1.511706717 0.596178273 0.578096882 1 0.207112494 0.307854155 10205 myelin protein zero like 2 "GO:0005515,GO:0005856,GO:0007156,GO:0009653,GO:0016021" protein binding|cytoskeleton|homophilic cell adhesion via plasma membrane adhesion molecules|anatomical structure morphogenesis|integral component of membrane MPZL3 67.77597177 63.46524684 72.0866967 1.135845211 0.183766243 0.753923975 1 0.714561937 0.798050196 196264 myelin protein zero like 3 "GO:0005515,GO:0007155,GO:0016021,GO:0030198,GO:0042633" protein binding|cell adhesion|integral component of membrane|extracellular matrix organization|hair cycle MR1 377.5682869 412.0038975 343.1326763 0.832838423 -0.263891466 0.370959 1 2.616360159 2.142542567 3140 "major histocompatibility complex, class I-related" "GO:0000139,GO:0002474,GO:0002854,GO:0005515,GO:0005615,GO:0005783,GO:0005789,GO:0005886,GO:0006955,GO:0009897,GO:0016021,GO:0019884,GO:0030881,GO:0031901,GO:0031902,GO:0032393,GO:0033077,GO:0042608,GO:0042612,GO:0045087,GO:0050829,GO:0050830" Golgi membrane|antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity directed against tumor cell target|protein binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|immune response|external side of plasma membrane|integral component of membrane|antigen processing and presentation of exogenous antigen|beta-2-microglobulin binding|early endosome membrane|late endosome membrane|MHC class I receptor activity|T cell differentiation in thymus|T cell receptor binding|MHC class I protein complex|innate immune response|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium MRAP2 15.61123866 18.72744989 12.49502743 0.667203891 -0.583800393 0.567501483 1 0.232592409 0.152589723 112609 melanocortin 2 receptor accessory protein 2 "GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0006112,GO:0007631,GO:0016021,GO:0030545,GO:0031780,GO:0031781,GO:0031782,GO:0031783,GO:0042802,GO:0070996,GO:0072659,GO:0097009,GO:0106070,GO:0106071,GO:0106072,GO:1903077" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|energy reserve metabolic process|feeding behavior|integral component of membrane|receptor regulator activity|corticotropin hormone receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding|identical protein binding|type 1 melanocortin receptor binding|protein localization to plasma membrane|energy homeostasis|regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|negative regulation of protein localization to plasma membrane MRAS 119.5588921 161.2641518 77.85363244 0.482770855 -1.050589512 0.017167216 0.770503287 1.518414148 0.720779563 22808 muscle RAS oncogene homolog "GO:0003924,GO:0005515,GO:0005525,GO:0005886,GO:0007265,GO:0007275,GO:0007517,GO:0019003,GO:0030036,GO:0030742,GO:1990830" GTPase activity|protein binding|GTP binding|plasma membrane|Ras protein signal transduction|multicellular organism development|muscle organ development|GDP binding|actin cytoskeleton organization|GTP-dependent protein binding|cellular response to leukemia inhibitory factor "hsa04010,hsa04014,hsa04015,hsa04072,hsa04137,hsa04140,hsa04218,hsa04371,hsa04625,hsa04810,hsa05205" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|Mitophagy - animal|Autophagy - animal|Cellular senescence|Apelin signaling pathway|C-type lectin receptor signaling pathway|Regulation of actin cytoskeleton|Proteoglycans in cancer MRC2 4767.619854 5054.330642 4480.909067 0.886548464 -0.173728595 0.468490991 1 45.99937532 40.09826616 9902 mannose receptor C type 2 "GO:0001649,GO:0005515,GO:0005518,GO:0005925,GO:0006897,GO:0016020,GO:0016021,GO:0030246,GO:0030574,GO:0038023" osteoblast differentiation|protein binding|collagen binding|focal adhesion|endocytosis|membrane|integral component of membrane|carbohydrate binding|collagen catabolic process|signaling receptor activity "hsa04145,hsa05152" Phagosome|Tuberculosis MRE11 1663.675673 1801.996845 1525.354502 0.846480118 -0.240451912 0.311789714 1 12.7901662 10.64545255 4361 "MRE11 homolog, double strand break repair nuclease" "GO:0000014,GO:0000019,GO:0000723,GO:0000724,GO:0000729,GO:0000781,GO:0003677,GO:0003678,GO:0003690,GO:0004518,GO:0004520,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0005737,GO:0005829,GO:0006260,GO:0006281,GO:0006302,GO:0006303,GO:0006310,GO:0006974,GO:0007004,GO:0007062,GO:0007095,GO:0007129,GO:0007131,GO:0008022,GO:0008283,GO:0008408,GO:0008409,GO:0016032,GO:0016605,GO:0030145,GO:0030870,GO:0031573,GO:0031860,GO:0031954,GO:0032206,GO:0032481,GO:0032508,GO:0033674,GO:0035861,GO:0042138,GO:0042802,GO:0043066,GO:0045296,GO:0097552,GO:0110025,GO:1901796" "single-stranded DNA endodeoxyribonuclease activity|regulation of mitotic recombination|telomere maintenance|double-strand break repair via homologous recombination|DNA double-strand break processing|chromosome, telomeric region|DNA binding|DNA helicase activity|double-stranded DNA binding|nuclease activity|endodeoxyribonuclease activity|protein binding|nucleus|nucleoplasm|replication fork|cytoplasm|cytosol|DNA replication|DNA repair|double-strand break repair|double-strand break repair via nonhomologous end joining|DNA recombination|cellular response to DNA damage stimulus|telomere maintenance via telomerase|sister chromatid cohesion|mitotic G2 DNA damage checkpoint|homologous chromosome pairing at meiosis|reciprocal meiotic recombination|protein C-terminus binding|cell population proliferation|3'-5' exonuclease activity|5'-3' exonuclease activity|viral process|PML body|manganese ion binding|Mre11 complex|intra-S DNA damage checkpoint|telomeric 3' overhang formation|positive regulation of protein autophosphorylation|positive regulation of telomere maintenance|positive regulation of type I interferon production|DNA duplex unwinding|positive regulation of kinase activity|site of double-strand break|meiotic DNA double-strand break formation|identical protein binding|negative regulation of apoptotic process|cadherin binding|mitochondrial double-strand break repair via homologous recombination|DNA strand resection involved in replication fork processing|regulation of signal transduction by p53 class mediator" "hsa03440,hsa03450,hsa04218" Homologous recombination|Non-homologous end-joining|Cellular senescence MREG 242.036465 235.1335375 248.9393926 1.058714955 0.082314215 0.819015361 1 3.484766659 3.62763789 55686 melanoregulin "GO:0005515,GO:0005765,GO:0016324,GO:0030318,GO:0030659,GO:0031300,GO:0031902,GO:0032400,GO:0032402,GO:0032991,GO:0033162,GO:0035091,GO:0042470,GO:0072385,GO:0090382" protein binding|lysosomal membrane|apical plasma membrane|melanocyte differentiation|cytoplasmic vesicle membrane|intrinsic component of organelle membrane|late endosome membrane|melanosome localization|melanosome transport|protein-containing complex|melanosome membrane|phosphatidylinositol binding|melanosome|minus-end-directed organelle transport along microtubule|phagosome maturation MRFAP1 5245.299888 4990.865395 5499.73438 1.10196007 0.140071948 0.560594446 1 183.0606964 198.3499735 93621 Morf4 family associated protein 1 "GO:0005515,GO:0005654,GO:0048471" protein binding|nucleoplasm|perinuclear region of cytoplasm MRFAP1L1 1204.347421 946.7766332 1461.918209 1.544100433 0.626766593 0.009754354 0.604180798 31.91896956 48.46135866 114932 Morf4 family associated protein 1 like 1 "GO:0005515,GO:0042802" protein binding|identical protein binding MRGBP 1308.770008 1202.718448 1414.821567 1.176353093 0.234321164 0.330428491 1 23.32371842 26.97780847 55257 MRG domain binding protein "GO:0005515,GO:0005654,GO:0006357,GO:0016573,GO:0035267,GO:0040008" protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|histone acetylation|NuA4 histone acetyltransferase complex|regulation of growth MRI1 777.3922302 752.2192372 802.5652233 1.066929937 0.09346544 0.714985447 1 11.72103888 12.29626421 84245 methylthioribose-1-phosphate isomerase 1 "GO:0001650,GO:0005515,GO:0005654,GO:0005829,GO:0019284,GO:0019509,GO:0042802,GO:0042995,GO:0046523" fibrillar center|protein binding|nucleoplasm|cytosol|L-methionine salvage from S-adenosylmethionine|L-methionine salvage from methylthioadenosine|identical protein binding|cell projection|S-methyl-5-thioribose-1-phosphate isomerase activity hsa00270 Cysteine and methionine metabolism MRM1 164.1287268 170.6278768 157.6295768 0.923820772 -0.11431511 0.783562418 1 2.025827849 1.840184798 79922 mitochondrial rRNA methyltransferase 1 "GO:0000451,GO:0003723,GO:0005515,GO:0005739,GO:0005759,GO:0070039" rRNA 2'-O-methylation|RNA binding|protein binding|mitochondrion|mitochondrial matrix|rRNA (guanosine-2'-O-)-methyltransferase activity MRM2 489.1510822 490.0349387 488.2672256 0.99639268 -0.005213673 0.993359882 1 15.34757279 15.03631476 29960 mitochondrial rRNA methyltransferase 2 "GO:0000451,GO:0001510,GO:0005730,GO:0005739,GO:0005759,GO:0006364,GO:0008173,GO:0008650,GO:0031167" rRNA 2'-O-methylation|RNA methylation|nucleolus|mitochondrion|mitochondrial matrix|rRNA processing|RNA methyltransferase activity|rRNA (uridine-2'-O-)-methyltransferase activity|rRNA methylation MRM3 276.3355246 290.2754733 262.395576 0.903953658 -0.145679281 0.660208004 1 8.959785138 7.963700899 55178 mitochondrial rRNA methyltransferase 3 "GO:0000451,GO:0003723,GO:0005515,GO:0005739,GO:0005759,GO:0042802,GO:0070039" rRNA 2'-O-methylation|RNA binding|protein binding|mitochondrion|mitochondrial matrix|identical protein binding|rRNA (guanosine-2'-O-)-methyltransferase activity MRNIP 172.9772752 175.8299462 170.1246042 0.967551933 -0.047588996 0.917019891 1 8.034007761 7.643243757 51149 MRN complex interacting protein "GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006974,GO:0007095,GO:0010212,GO:0030870,GO:0045860,GO:0071168,GO:1905168,GO:2001032" chromatin binding|protein binding|nucleus|nucleoplasm|DNA repair|cellular response to DNA damage stimulus|mitotic G2 DNA damage checkpoint|response to ionizing radiation|Mre11 complex|positive regulation of protein kinase activity|protein localization to chromatin|positive regulation of double-strand break repair via homologous recombination|regulation of double-strand break repair via nonhomologous end joining MROH1 1513.806385 1526.287166 1501.325603 0.983645566 -0.023789527 0.923416716 1 11.87739003 11.48764048 727957 maestro heat like repeat family member 1 MROH6 32.5056954 33.29324424 31.71814655 0.952690171 -0.069920991 0.969092093 1 0.499241151 0.467663245 642475 maestro heat like repeat family member 6 MROH8 11.08789204 13.52538047 8.650403604 0.639568227 -0.644829827 0.5980771 1 0.196094729 0.123317292 140699 maestro heat like repeat family member 8 MRPL1 254.3182564 267.3863678 241.250145 0.902252972 -0.148396105 0.663510925 1 12.14461193 10.77415307 65008 mitochondrial ribosomal protein L1 "GO:0000470,GO:0003723,GO:0003735,GO:0005515,GO:0005743,GO:0022625,GO:0070125,GO:0070126" maturation of LSU-rRNA|RNA binding|structural constituent of ribosome|protein binding|mitochondrial inner membrane|cytosolic large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL10 1533.049011 1577.267446 1488.830576 0.943930327 -0.083247719 0.72886264 1 41.69185968 38.69567132 124995 mitochondrial ribosomal protein L10 "GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0015934,GO:0042254,GO:0070125,GO:0070126,GO:1990904" RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|large ribosomal subunit|ribosome biogenesis|mitochondrial translational elongation|mitochondrial translational termination|ribonucleoprotein complex hsa03010 Ribosome MRPL11 1044.220605 982.1507052 1106.290505 1.126395877 0.171713959 0.484532758 1 21.82163948 24.168495 65003 mitochondrial ribosomal protein L11 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0015934,GO:0070125,GO:0070126,GO:0070180" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination|large ribosomal subunit rRNA binding hsa03010 Ribosome MRPL12 1353.265001 1298.436526 1408.093476 1.084453069 0.116967621 0.627718837 1 68.67707725 73.23079436 6182 mitochondrial ribosomal protein L12 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0006390,GO:0045893,GO:0070125,GO:0070126" "RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial transcription|positive regulation of transcription, DNA-templated|mitochondrial translational elongation|mitochondrial translational termination" hsa03010 Ribosome MRPL13 1148.402231 941.5745638 1355.229898 1.43932297 0.525390355 0.030725813 0.895820653 39.88103486 56.44115002 28998 mitochondrial ribosomal protein L13 "GO:0003723,GO:0003729,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0005840,GO:0006412,GO:0017148,GO:0070125,GO:0070126" RNA binding|mRNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|ribosome|translation|negative regulation of translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL14 525.3233783 468.1862472 582.4605093 1.244078639 0.315077682 0.24425877 1 18.26479497 22.3426053 64928 mitochondrial ribosomal protein L14 "GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL15 2031.088271 2073.544868 1988.631673 0.959049261 -0.060323175 0.800413753 1 52.37164155 49.38650356 29088 mitochondrial ribosomal protein L15 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126,GO:1990830" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination|cellular response to leukemia inhibitory factor hsa03010 Ribosome MRPL16 786.1917032 680.4306792 891.9527272 1.310864948 0.39051906 0.121510064 1 33.53031835 43.21821307 54948 mitochondrial ribosomal protein L16 "GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0019843,GO:0032543,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|rRNA binding|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL17 1290.340082 1122.606579 1458.073585 1.298828648 0.377211111 0.117275625 1 25.99195222 33.19417947 63875 mitochondrial ribosomal protein L17 "GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0015934,GO:0019904,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|large ribosomal subunit|protein domain specific binding|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL18 820.8619003 808.4015868 833.3222138 1.030827039 0.043802285 0.866054061 1 52.5492167 53.26270601 29074 mitochondrial ribosomal protein L18 "GO:0003735,GO:0005515,GO:0005615,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0008097,GO:0035928,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|extracellular space|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|5S rRNA binding|rRNA import into mitochondrion|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL19 1188.932484 1236.011693 1141.853276 0.923820772 -0.11431511 0.639027473 1 8.42986228 7.657365567 9801 mitochondrial ribosomal protein L19 "GO:0003735,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005762,GO:0031965,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|nuclear membrane|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL2 415.2068546 428.6505196 401.7631896 0.937274472 -0.093456505 0.750689917 1 14.17366196 13.06231155 51069 mitochondrial ribosomal protein L2 "GO:0003723,GO:0003735,GO:0005654,GO:0005739,GO:0005743,GO:0005762,GO:0032543,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL20 746.7100815 665.8648849 827.5552781 1.242827632 0.313626223 0.216960102 1 34.00572737 41.55603924 55052 mitochondrial ribosomal protein L20 "GO:0000027,GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0019843,GO:0070125,GO:0070126" ribosomal large subunit assembly|RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|rRNA binding|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL21 458.2556974 435.9334168 480.577978 1.102411422 0.140662741 0.618856379 1 23.01183506 24.94400216 219927 mitochondrial ribosomal protein L21 "GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL22 652.5073514 589.9146715 715.1000313 1.212209267 0.277638776 0.284546016 1 9.922049101 11.82633427 29093 mitochondrial ribosomal protein L22 "GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0015934,GO:0042255,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|large ribosomal subunit|ribosome assembly|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL24 1291.681208 1372.305911 1211.056505 0.882497477 -0.180335941 0.454705308 1 67.56221798 58.62576861 79590 mitochondrial ribosomal protein L24 "GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL27 442.5997994 428.6505196 456.5490791 1.065084628 0.090968066 0.753030409 1 33.34736211 34.9234211 51264 mitochondrial ribosomal protein L27 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL28 1257.521771 1169.425204 1345.618338 1.150666442 0.202469682 0.402047173 1 39.52506259 44.71911419 10573 mitochondrial ribosomal protein L28 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0005829,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|cytosol|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL3 1798.073961 1810.320156 1785.827766 0.986470686 -0.019651914 0.936404332 1 56.56525731 54.86623129 11222 mitochondrial ribosomal protein L3 "GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL30 1380.552921 1459.700677 1301.405164 0.891556183 -0.16560238 0.490617041 1 17.56517302 15.39828405 51263 mitochondrial ribosomal protein L30 "GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL32 685.5628218 650.2586767 720.866967 1.108584926 0.148719296 0.565637397 1 40.39943009 44.03676283 64983 mitochondrial ribosomal protein L32 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL33 521.9152874 378.7106533 665.1199215 1.756274654 0.812518478 0.002778292 0.345392232 39.78561324 68.70520959 9553 mitochondrial ribosomal protein L33 "GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL34 424.3132985 390.155206 458.471391 1.175100022 0.232783561 0.415854574 1 23.03303791 26.61320843 64981 mitochondrial ribosomal protein L34 "GO:0003735,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL35 599.8570098 557.6618411 642.0521786 1.151328872 0.203299992 0.441454342 1 17.8639781 20.22314762 51318 mitochondrial ribosomal protein L35 "GO:0003735,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL36 469.8983949 464.0245917 475.7721982 1.025316776 0.036069705 0.904399569 1 20.13344684 20.29772546 64979 mitochondrial ribosomal protein L36 "GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0016604,GO:0042254,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|nuclear body|ribosome biogenesis|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL37 2224.458641 2128.686804 2320.230478 1.089982084 0.124304421 0.599881999 1 61.47408137 65.88439853 51253 mitochondrial ribosomal protein L37 "GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination MRPL38 1142.342187 1072.666713 1212.017661 1.12991076 0.176208833 0.469636538 1 42.154824 46.83414576 64978 mitochondrial ribosomal protein L38 "GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL39 659.2505343 552.4597717 766.0412969 1.386601045 0.471552753 0.068294445 1 9.055209655 12.34585613 54148 mitochondrial ribosomal protein L39 "GO:0000166,GO:0003723,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0070125,GO:0070126" nucleotide binding|RNA binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL4 702.7837567 749.0979955 656.4695179 0.876346649 -0.190426438 0.458765843 1 21.01891863 18.11162751 51073 mitochondrial ribosomal protein L4 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL40 545.6806461 535.8131496 555.5481426 1.036831856 0.052181951 0.852118355 1 38.4346277 39.18340648 64976 mitochondrial ribosomal protein L40 "GO:0003723,GO:0005515,GO:0005634,GO:0005730,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0009653,GO:0070125,GO:0070126" RNA binding|protein binding|nucleus|nucleolus|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|anatomical structure morphogenesis|mitochondrial translational elongation|mitochondrial translational termination MRPL41 671.1951723 626.3291574 716.0611872 1.14326657 0.193161829 0.455729751 1 57.43305152 64.56253507 64975 mitochondrial ribosomal protein L41 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0006915,GO:0007049,GO:0070125,GO:0070126,GO:1990904" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|apoptotic process|cell cycle|mitochondrial translational elongation|mitochondrial translational termination|ribonucleoprotein complex MRPL42 1397.780115 1344.214736 1451.345494 1.079697651 0.11062737 0.645932138 1 4.610428658 4.894571097 28977 mitochondrial ribosomal protein L42 "GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0005763,GO:0005886,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial small ribosomal subunit|plasma membrane|translation|mitochondrial translational elongation|mitochondrial translational termination MRPL43 2077.413684 1800.956431 2353.870936 1.307011594 0.386271939 0.102545435 1 33.02877481 42.44661701 84545 mitochondrial ribosomal protein L43 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination MRPL44 582.7348402 511.8836303 653.5860501 1.276825457 0.352561321 0.182688766 1 14.31776129 17.9753696 65080 mitochondrial ribosomal protein L44 "GO:0003723,GO:0003725,GO:0004525,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005743,GO:0005762,GO:0005886,GO:0006396,GO:0016604,GO:0030422,GO:0031053,GO:0031054,GO:0070125,GO:0070126,GO:0090502" "RNA binding|double-stranded RNA binding|ribonuclease III activity|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|plasma membrane|RNA processing|nuclear body|production of siRNA involved in RNA interference|primary miRNA processing|pre-miRNA processing|mitochondrial translational elongation|mitochondrial translational termination|RNA phosphodiester bond hydrolysis, endonucleolytic" MRPL45 1104.802384 1109.081199 1100.52357 0.992284037 -0.01117495 0.967531173 1 38.11308769 37.18615863 84311 mitochondrial ribosomal protein L45 "GO:0003723,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" RNA binding|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL46 278.7881043 266.345954 291.2302547 1.093428492 0.128858874 0.698036222 1 14.41622114 15.49933268 26589 mitochondrial ribosomal protein L46 "GO:0003674,GO:0003735,GO:0005654,GO:0005739,GO:0005743,GO:0005762,GO:0008150,GO:0016787,GO:0030054,GO:0070125,GO:0070126" molecular_function|structural constituent of ribosome|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|biological_process|hydrolase activity|cell junction|mitochondrial translational elongation|mitochondrial translational termination MRPL47 583.08144 546.2172884 619.9455916 1.134979805 0.182666628 0.492187657 1 21.4027994 23.88525563 57129 mitochondrial ribosomal protein L47 "GO:0003674,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0008150,GO:0032543,GO:0070125,GO:0070126" molecular_function|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|biological_process|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination MRPL48 324.1605791 271.5480234 376.7731347 1.387500929 0.472488738 0.124221581 1 12.54720253 17.11793486 51642 mitochondrial ribosomal protein L48 "GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0070125,GO:0070126" protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL49 1614.861738 1491.953508 1737.769968 1.164761475 0.220034544 0.355385987 1 39.30050178 45.00971591 740 mitochondrial ribosomal protein L49 "GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL50 578.7216397 532.6919079 624.7513714 1.172819339 0.229980798 0.386702109 1 8.521818969 9.827308763 54534 mitochondrial ribosomal protein L50 "GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL51 1416.265375 1286.991973 1545.538777 1.200892321 0.264106796 0.270083551 1 76.48596459 90.31439862 51258 mitochondrial ribosomal protein L51 "GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0032543,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination MRPL52 867.5226236 796.9570341 938.088213 1.177087563 0.235221646 0.346203094 1 34.83385108 40.31637168 122704 mitochondrial ribosomal protein L52 "GO:0003735,GO:0005654,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0070125,GO:0070126" structural constituent of ribosome|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination MRPL53 380.8731965 359.9832034 401.7631896 1.116060932 0.158415795 0.593850723 1 38.73314908 42.50518316 116540 mitochondrial ribosomal protein L53 "GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL54 213.1080516 169.5874629 256.6286403 1.51325243 0.597652668 0.092289173 1 14.8858079 22.14904313 116541 mitochondrial ribosomal protein L54 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL55 292.8733207 295.4775427 290.2690987 0.982372792 -0.02565749 0.947118556 1 11.4935083 11.10197176 128308 mitochondrial ribosomal protein L55 "GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination MRPL57 600.139443 552.4597717 647.8191143 1.172608663 0.22972162 0.383802577 1 12.86377078 14.83175592 78988 mitochondrial ribosomal protein L57 "GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0032543,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination MRPL58 371.0188327 366.2256867 375.8119788 1.026175914 0.037278069 0.908974125 1 17.83283924 17.99341058 3396 mitochondrial ribosomal protein L58 "GO:0004045,GO:0005739,GO:0005743,GO:0005759,GO:0005762,GO:0016150,GO:0070125,GO:0070126" "aminoacyl-tRNA hydrolase activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|mitochondrial large ribosomal subunit|translation release factor activity, codon nonspecific|mitochondrial translational elongation|mitochondrial translational termination" MRPL9 970.9896991 939.493736 1002.485662 1.067048798 0.093626155 0.706997892 1 40.96327939 42.97839344 65005 mitochondrial ribosomal protein L9 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS10 1047.277066 1049.777608 1044.776524 0.995236054 -0.006889344 0.981941085 1 26.22879284 25.66702788 55173 mitochondrial ribosomal protein S10 "GO:0003674,GO:0005739,GO:0005743,GO:0005763,GO:0008150,GO:0070125,GO:0070126" molecular_function|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|biological_process|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS11 463.3684481 469.2266611 457.5102351 0.975030349 -0.03648097 0.903609132 1 6.621302089 6.347938563 64963 mitochondrial ribosomal protein S11 "GO:0000028,GO:0000462,GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0022627,GO:0032543,GO:0042769,GO:0048027,GO:0070125,GO:0070126,GO:0070181" "ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|cytosolic small ribosomal subunit|mitochondrial translation|DNA damage response, detection of DNA damage|mRNA 5'-UTR binding|mitochondrial translational elongation|mitochondrial translational termination|small ribosomal subunit rRNA binding" hsa03010 Ribosome MRPS12 339.5982106 323.5687175 355.6277037 1.099079375 0.13629558 0.659201927 1 17.5490526 18.96504652 6183 mitochondrial ribosomal protein S12 "GO:0003723,GO:0003735,GO:0005515,GO:0005743,GO:0005761,GO:0005763,GO:0005840,GO:0006412,GO:0032543,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial small ribosomal subunit|ribosome|translation|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS14 474.1644605 412.0038975 536.3250234 1.301747451 0.380449582 0.169459409 1 10.39616585 13.30672292 63931 mitochondrial ribosomal protein S14 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005761,GO:0005763,GO:0006412,GO:0015935,GO:0031965,GO:0032543,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial small ribosomal subunit|translation|small ribosomal subunit|nuclear membrane|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS15 719.4360236 668.9861265 769.8859208 1.150824943 0.202668395 0.428644775 1 37.46333686 42.3922924 64960 mitochondrial ribosomal protein S15 "GO:0003723,GO:0003735,GO:0005654,GO:0005730,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0032543,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|nucleoplasm|nucleolus|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS16 2836.597442 2718.601475 2954.593409 1.086806373 0.12009493 0.612393046 1 56.25698494 60.11734713 51021 mitochondrial ribosomal protein S16 "GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005763,GO:0005829,GO:0006412,GO:0015935,GO:0032543,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|cytosol|translation|small ribosomal subunit|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS17 373.4714124 342.2961674 404.6466575 1.182153632 0.241417539 0.41539432 1 10.22828518 11.8890712 51373 mitochondrial ribosomal protein S17 "GO:0003735,GO:0005515,GO:0005743,GO:0005763,GO:0006412,GO:0019843,GO:0032543,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|rRNA binding|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS18A 494.4374399 490.0349387 498.8399412 1.017968112 0.025692369 0.933163085 1 18.85527328 18.87288021 55168 mitochondrial ribosomal protein S18A "GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0005763,GO:0006412,GO:0032543,GO:0070125,GO:0070126,GO:0070181" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial small ribosomal subunit|translation|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination|small ribosomal subunit rRNA binding hsa03010 Ribosome MRPS18B 1226.665401 1217.284243 1236.046559 1.015413259 0.022067003 0.930809693 1 33.87081479 33.81735623 28973 mitochondrial ribosomal protein S18B "GO:0003735,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0030054,GO:0032543,GO:0070125,GO:0070126" structural constituent of ribosome|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|cell junction|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa05203 Viral carcinogenesis MRPS18C 337.839445 315.2454064 360.4334835 1.143342539 0.193257692 0.528655771 1 10.85423738 12.20244493 51023 mitochondrial ribosomal protein S18C "GO:0003735,GO:0005743,GO:0005763,GO:0006412,GO:0070125,GO:0070126,GO:0070181" structural constituent of ribosome|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination|small ribosomal subunit rRNA binding hsa03010 Ribosome MRPS2 1206.316965 1326.5277 1086.10623 0.818758802 -0.288489584 0.233323441 1 42.72440876 34.39562629 51116 mitochondrial ribosomal protein S2 "GO:0003735,GO:0005739,GO:0005743,GO:0005763,GO:0032543,GO:0061668,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|mitochondrial translation|mitochondrial ribosome assembly|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS21 509.0975835 483.7924554 534.4027115 1.104611503 0.143539057 0.601956923 1 16.76565855 18.20963989 54460 mitochondrial ribosomal protein S21 "GO:0003723,GO:0003735,GO:0005743,GO:0005763,GO:0006412,GO:0032543,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS22 738.0345258 728.2897178 747.7793338 1.026760801 0.038100123 0.886187195 1 27.56559128 27.8296517 56945 mitochondrial ribosomal protein S22 "GO:0003735,GO:0005739,GO:0005743,GO:0005761,GO:0005763,GO:0008150,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial small ribosomal subunit|biological_process|mitochondrial translational elongation|mitochondrial translational termination MRPS23 886.8791065 863.5435226 910.2146903 1.054046109 0.075937979 0.7637349 1 8.216389851 8.515532791 51649 mitochondrial ribosomal protein S23 "GO:0003723,GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005840,GO:0031965,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|ribosome|nuclear membrane|mitochondrial translational elongation|mitochondrial translational termination MRPS25 765.2041736 785.5124814 744.8958659 0.948292845 -0.076595444 0.766237303 1 9.169150792 8.549540372 64432 mitochondrial ribosomal protein S25 "GO:0003735,GO:0005739,GO:0005743,GO:0005840,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|ribosome|mitochondrial translational elongation|mitochondrial translational termination MRPS26 579.9105086 563.9043244 595.9166927 1.056769148 0.079660254 0.768791684 1 29.62060766 30.77834534 64949 mitochondrial ribosomal protein S26 "GO:0003723,GO:0005654,GO:0005739,GO:0005743,GO:0005763,GO:0042769,GO:0070125,GO:0070126" "RNA binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|DNA damage response, detection of DNA damage|mitochondrial translational elongation|mitochondrial translational termination" MRPS27 1993.564174 1971.584308 2015.54404 1.022296653 0.031813903 0.895136183 1 37.41814754 37.61234411 23107 mitochondrial ribosomal protein S27 "GO:0000049,GO:0005515,GO:0005730,GO:0005737,GO:0005739,GO:0005743,GO:0005763,GO:0008283,GO:0019843,GO:0070125,GO:0070126,GO:0070131,GO:0097177" tRNA binding|protein binding|nucleolus|cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|cell population proliferation|rRNA binding|mitochondrial translational elongation|mitochondrial translational termination|positive regulation of mitochondrial translation|mitochondrial ribosome binding MRPS28 20.4566474 19.76786377 21.14543103 1.069687209 0.097188995 0.973111657 1 1.25891952 1.324115742 28957 mitochondrial ribosomal protein S28 "GO:0003723,GO:0005739,GO:0005743,GO:0005763,GO:0008150,GO:0070125,GO:0070126" RNA binding|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|biological_process|mitochondrial translational elongation|mitochondrial translational termination MRPS30 945.5291271 914.5238028 976.5344513 1.067806489 0.094650222 0.704694548 1 29.61556707 31.094515 10884 mitochondrial ribosomal protein S30 "GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0006915,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|apoptotic process|mitochondrial translational elongation|mitochondrial translational termination MRPS31 431.2244438 432.8121752 429.6367123 0.992663185 -0.010623807 0.979295737 1 15.54400425 15.17176127 10240 mitochondrial ribosomal protein S31 "GO:0003723,GO:0003735,GO:0005515,GO:0005730,GO:0005739,GO:0005743,GO:0005763,GO:0019904,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|protein binding|nucleolus|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|protein domain specific binding|mitochondrial translational elongation|mitochondrial translational termination MRPS33 691.671327 697.0773014 686.2653526 0.984489599 -0.022552131 0.935968023 1 8.573803734 8.299574894 51650 mitochondrial ribosomal protein S33 "GO:0003735,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination MRPS34 1071.667656 1046.656366 1096.678946 1.047792744 0.067353377 0.785974028 1 54.81661097 56.47532607 65993 mitochondrial ribosomal protein S34 "GO:0003735,GO:0005739,GO:0005743,GO:0005763,GO:0032543,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination MRPS35 1297.141787 1238.09252 1356.191054 1.095387486 0.131441304 0.586571378 1 33.37107187 35.94256859 60488 mitochondrial ribosomal protein S35 "GO:0003723,GO:0003735,GO:0005743,GO:0005763,GO:0042769,GO:0070125,GO:0070126" "RNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial small ribosomal subunit|DNA damage response, detection of DNA damage|mitochondrial translational elongation|mitochondrial translational termination" MRPS36 403.8220526 356.8619617 450.7821434 1.263183504 0.337064236 0.243318562 1 14.4829407 17.98847623 92259 mitochondrial ribosomal protein S36 "GO:0003735,GO:0005739,GO:0005743,GO:0005763,GO:0006103,GO:0006412,GO:0009353,GO:0070125,GO:0070126" structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|2-oxoglutarate metabolic process|translation|mitochondrial oxoglutarate dehydrogenase complex|mitochondrial translational elongation|mitochondrial translational termination MRPS5 1412.053415 1403.518328 1420.588503 1.012162417 0.017440811 0.945098697 1 19.79471289 19.70019808 64969 mitochondrial ribosomal protein S5 "GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0070125,GO:0070126" RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS6 684.2953094 516.0452858 852.545333 1.652074646 0.724278874 0.004955252 0.428880196 29.58151284 48.05307958 64968 mitochondrial ribosomal protein S6 "GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0015935,GO:0032543,GO:0070125,GO:0070126,GO:0070181" structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|small ribosomal subunit|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination|small ribosomal subunit rRNA binding hsa03010 Ribosome MRPS7 1022.718514 972.7869803 1072.650047 1.102656664 0.140983647 0.567404678 1 43.11947943 46.75036375 51081 mitochondrial ribosomal protein S7 "GO:0000028,GO:0003723,GO:0003729,GO:0003735,GO:0005743,GO:0005763,GO:0005840,GO:0006412,GO:0019843,GO:0032543,GO:0070125,GO:0070126" ribosomal small subunit assembly|RNA binding|mRNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial small ribosomal subunit|ribosome|translation|rRNA binding|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS9 623.5934148 587.8338437 659.3529858 1.121665574 0.165642599 0.528517046 1 19.16408787 21.13599624 64965 mitochondrial ribosomal protein S9 "GO:0003723,GO:0003735,GO:0005515,GO:0005730,GO:0005739,GO:0005743,GO:0005763,GO:0015935,GO:0042769,GO:0070125,GO:0070126" "RNA binding|structural constituent of ribosome|protein binding|nucleolus|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|small ribosomal subunit|DNA damage response, detection of DNA damage|mitochondrial translational elongation|mitochondrial translational termination" hsa03010 Ribosome MRRF 787.9643313 853.1393838 722.7892789 0.847211244 -0.239206358 0.343406615 1 19.1707288 15.96987487 92399 mitochondrial ribosome recycling factor "GO:0005515,GO:0005739,GO:0005759,GO:0006412,GO:0032790,GO:0043023,GO:0070126" protein binding|mitochondrion|mitochondrial matrix|translation|ribosome disassembly|ribosomal large subunit binding|mitochondrial translational termination MRS2 506.4864879 503.5603192 509.4126567 1.011621919 0.016670202 0.959199696 1 7.003932429 6.96676814 57380 magnesium transporter MRS2 "GO:0005739,GO:0005743,GO:0006089,GO:0015095,GO:0015693,GO:0016021,GO:0045016,GO:0055085" mitochondrion|mitochondrial inner membrane|lactate metabolic process|magnesium ion transmembrane transporter activity|magnesium ion transport|integral component of membrane|mitochondrial magnesium ion transmembrane transport|transmembrane transport MRTFA 741.2696239 750.1384094 732.4008385 0.976354269 -0.034523372 0.897267187 1 8.130281928 7.805203196 57591 myocardin related transcription factor A "GO:0003713,GO:0003779,GO:0003785,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0010735,GO:0030036,GO:0043522,GO:0044319,GO:0045944,GO:0051145" "transcription coactivator activity|actin binding|actin monomer binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|positive regulation of transcription via serum response element binding|actin cytoskeleton organization|leucine zipper domain binding|wound healing, spreading of cells|positive regulation of transcription by RNA polymerase II|smooth muscle cell differentiation" MRTFB 1054.41531 1224.56714 884.2634795 0.722102897 -0.469723664 0.054876317 1 4.72681163 3.35612835 57496 myocardin related transcription factor B "GO:0003713,GO:0005515,GO:0005634,GO:0007517,GO:0045296,GO:0045844,GO:0045944,GO:0051145" transcription coactivator activity|protein binding|nucleus|muscle organ development|cadherin binding|positive regulation of striated muscle tissue development|positive regulation of transcription by RNA polymerase II|smooth muscle cell differentiation MRTO4 676.9319255 701.2389569 652.6248941 0.930674042 -0.103652127 0.69121861 1 15.33763701 14.03547887 51154 "MRT4 homolog, ribosome maturation factor" "GO:0000027,GO:0000956,GO:0003723,GO:0005515,GO:0005730,GO:0005737,GO:0006364,GO:0030687,GO:0042273" "ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process|RNA binding|protein binding|nucleolus|cytoplasm|rRNA processing|preribosome, large subunit precursor|ribosomal large subunit biogenesis" MSANTD1 6.044338479 7.282897178 4.80577978 0.65987198 -0.599741937 0.771875613 1 0.05221317 0.033877467 345222 Myb/SANT DNA binding domain containing 1 "GO:0016604,GO:0045893" "nuclear body|positive regulation of transcription, DNA-templated" MSANTD2 651.5059521 689.7944042 613.2174999 0.888985901 -0.169767556 0.514716513 1 1.634828118 1.429019485 79684 Myb/SANT DNA binding domain containing 2 MSANTD3 937.8845388 903.0792501 972.6898275 1.077081361 0.107127232 0.667644904 1 22.5213457 23.85140824 91283 Myb/SANT DNA binding domain containing 3 "GO:0005515,GO:0042802" protein binding|identical protein binding MSANTD4 811.2553712 795.9166202 826.5941222 1.038543613 0.054561802 0.832517307 1 10.00391125 10.21564395 84437 Myb/SANT DNA binding domain containing 4 with coiled-coils "GO:0005515,GO:0005634" protein binding|nucleus MSH2 1952.640818 1957.018513 1948.263123 0.995526159 -0.00646887 0.980620739 1 10.29598592 10.07840473 4436 mutS homolog 2 "GO:0000287,GO:0000400,GO:0000406,GO:0000781,GO:0001701,GO:0002204,GO:0003677,GO:0003682,GO:0003690,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006119,GO:0006281,GO:0006298,GO:0006301,GO:0006302,GO:0006310,GO:0007050,GO:0007281,GO:0008022,GO:0008094,GO:0008340,GO:0008584,GO:0010165,GO:0010224,GO:0016020,GO:0016446,GO:0016447,GO:0016887,GO:0019237,GO:0019724,GO:0019899,GO:0019901,GO:0030183,GO:0030983,GO:0031573,GO:0032137,GO:0032139,GO:0032142,GO:0032143,GO:0032181,GO:0032300,GO:0032301,GO:0032302,GO:0032357,GO:0032405,GO:0042771,GO:0042803,GO:0043524,GO:0043531,GO:0043570,GO:0045190,GO:0045910,GO:0048298,GO:0048304,GO:0051096,GO:0071168" "magnesium ion binding|four-way junction DNA binding|double-strand/single-strand DNA junction binding|chromosome, telomeric region|in utero embryonic development|somatic recombination of immunoglobulin genes involved in immune response|DNA binding|chromatin binding|double-stranded DNA binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|oxidative phosphorylation|DNA repair|mismatch repair|postreplication repair|double-strand break repair|DNA recombination|cell cycle arrest|germ cell development|protein C-terminus binding|DNA-dependent ATPase activity|determination of adult lifespan|male gonad development|response to X-ray|response to UV-B|membrane|somatic hypermutation of immunoglobulin genes|somatic recombination of immunoglobulin gene segments|ATPase activity|centromeric DNA binding|B cell mediated immunity|enzyme binding|protein kinase binding|B cell differentiation|mismatched DNA binding|intra-S DNA damage checkpoint|guanine/thymine mispair binding|dinucleotide insertion or deletion binding|single guanine insertion binding|single thymine insertion binding|dinucleotide repeat insertion binding|mismatch repair complex|MutSalpha complex|MutSbeta complex|oxidized purine DNA binding|MutLalpha complex binding|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|protein homodimerization activity|negative regulation of neuron apoptotic process|ADP binding|maintenance of DNA repeat elements|isotype switching|negative regulation of DNA recombination|positive regulation of isotype switching to IgA isotypes|positive regulation of isotype switching to IgG isotypes|positive regulation of helicase activity|protein localization to chromatin" "hsa01524,hsa03430,hsa05200,hsa05210" Platinum drug resistance|Mismatch repair|Pathways in cancer|Colorectal cancer MSH3 490.7909609 495.2370081 486.3449137 0.98204477 -0.026139299 0.931988892 1 5.94865832 5.744093364 4437 mutS homolog 3 "GO:0000710,GO:0000735,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006281,GO:0006298,GO:0006312,GO:0007131,GO:0008094,GO:0016020,GO:0016447,GO:0019899,GO:0030983,GO:0032135,GO:0032137,GO:0032139,GO:0032142,GO:0032181,GO:0032300,GO:0032302,GO:0032357,GO:0042803,GO:0043111,GO:0043570,GO:0045910,GO:0051096" meiotic mismatch repair|removal of nonhomologous ends|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|DNA repair|mismatch repair|mitotic recombination|reciprocal meiotic recombination|DNA-dependent ATPase activity|membrane|somatic recombination of immunoglobulin gene segments|enzyme binding|mismatched DNA binding|DNA insertion or deletion binding|guanine/thymine mispair binding|dinucleotide insertion or deletion binding|single guanine insertion binding|dinucleotide repeat insertion binding|mismatch repair complex|MutSbeta complex|oxidized purine DNA binding|protein homodimerization activity|replication fork arrest|maintenance of DNA repeat elements|negative regulation of DNA recombination|positive regulation of helicase activity "hsa01524,hsa03430,hsa05200,hsa05210" Platinum drug resistance|Mismatch repair|Pathways in cancer|Colorectal cancer MSH5 521.4831705 556.6214272 486.3449137 0.873744506 -0.194716617 0.474355352 1 10.70481533 9.196759213 4439 mutS homolog 5 "GO:0000228,GO:0000710,GO:0005515,GO:0005524,GO:0007131,GO:0008094,GO:0030983" nuclear chromosome|meiotic mismatch repair|protein binding|ATP binding|reciprocal meiotic recombination|DNA-dependent ATPase activity|mismatched DNA binding MSH6 2423.108495 2499.074146 2347.142845 0.939204964 -0.090488061 0.702921396 1 28.51635537 26.33453028 2956 mutS homolog 6 "GO:0000287,GO:0000400,GO:0000710,GO:0000785,GO:0003682,GO:0003690,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006281,GO:0006290,GO:0006298,GO:0008094,GO:0008340,GO:0008630,GO:0009411,GO:0016032,GO:0016446,GO:0016447,GO:0016887,GO:0019899,GO:0030983,GO:0032137,GO:0032142,GO:0032143,GO:0032300,GO:0032301,GO:0032357,GO:0032405,GO:0035064,GO:0036297,GO:0042803,GO:0043231,GO:0043531,GO:0043570,GO:0045190,GO:0045910,GO:0051096,GO:0097193" magnesium ion binding|four-way junction DNA binding|meiotic mismatch repair|chromatin|chromatin binding|double-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|Golgi apparatus|cytosol|DNA repair|pyrimidine dimer repair|mismatch repair|DNA-dependent ATPase activity|determination of adult lifespan|intrinsic apoptotic signaling pathway in response to DNA damage|response to UV|viral process|somatic hypermutation of immunoglobulin genes|somatic recombination of immunoglobulin gene segments|ATPase activity|enzyme binding|mismatched DNA binding|guanine/thymine mispair binding|single guanine insertion binding|single thymine insertion binding|mismatch repair complex|MutSalpha complex|oxidized purine DNA binding|MutLalpha complex binding|methylated histone binding|interstrand cross-link repair|protein homodimerization activity|intracellular membrane-bounded organelle|ADP binding|maintenance of DNA repeat elements|isotype switching|negative regulation of DNA recombination|positive regulation of helicase activity|intrinsic apoptotic signaling pathway "hsa01524,hsa03430,hsa05200,hsa05210" Platinum drug resistance|Mismatch repair|Pathways in cancer|Colorectal cancer MSI2 771.4762251 824.0077951 718.9446551 0.872497396 -0.19677727 0.43767893 1 2.451133246 2.102820675 124540 musashi RNA binding protein 2 "GO:0003723,GO:0005515,GO:0005737,GO:0005829,GO:0005844,GO:0042802,GO:0043231" RNA binding|protein binding|cytoplasm|cytosol|polysome|identical protein binding|intracellular membrane-bounded organelle hsa03015 mRNA surveillance pathway MSL1 2106.282346 1915.401958 2297.162735 1.199311051 0.262205882 0.267656537 1 17.88652356 21.09254347 339287 MSL complex subunit 1 "GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0016607,GO:0043984,GO:0072487" chromatin binding|protein binding|nucleus|nucleoplasm|nuclear speck|histone H4-K16 acetylation|MSL complex MSL2 680.8658681 678.3498515 683.3818847 1.00741805 0.010662485 0.973337505 1 6.073189871 6.015860619 55167 MSL complex subunit 2 "GO:0005654,GO:0016567,GO:0043984,GO:0046872,GO:0061630,GO:0072487" nucleoplasm|protein ubiquitination|histone H4-K16 acetylation|metal ion binding|ubiquitin protein ligase activity|MSL complex MSL3 640.4035831 612.8037769 668.0033894 1.090077142 0.124430234 0.635729466 1 12.10370514 12.97318904 10943 MSL complex subunit 3 "GO:0000123,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006342,GO:0006355,GO:0016573,GO:0016575,GO:0035064,GO:0035267,GO:0043967,GO:0043968,GO:0043984,GO:0046972,GO:0072487" "histone acetyltransferase complex|DNA binding|protein binding|nucleus|nucleoplasm|chromatin silencing|regulation of transcription, DNA-templated|histone acetylation|histone deacetylation|methylated histone binding|NuA4 histone acetyltransferase complex|histone H4 acetylation|histone H2A acetylation|histone H4-K16 acetylation|histone acetyltransferase activity (H4-K16 specific)|MSL complex" MSLN 1923.727496 1854.017539 1993.437453 1.075198811 0.104603447 0.659893713 1 44.48988692 47.03501164 10232 mesothelin "GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005794,GO:0005886,GO:0007155,GO:0007160,GO:0009986,GO:0016020,GO:0031016,GO:0031225,GO:0043687,GO:0044267" protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|plasma membrane|cell adhesion|cell-matrix adhesion|cell surface|membrane|pancreas development|anchored component of membrane|post-translational protein modification|cellular protein metabolic process MSMO1 631.2084349 573.2680493 689.1488204 1.202140641 0.26560569 0.308861333 1 13.19856004 15.60102061 6307 methylsterol monooxygenase 1 "GO:0000254,GO:0005506,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0006631,GO:0006695,GO:0008202,GO:0016020,GO:0016021,GO:0016126,GO:0016491,GO:0055114" C-4 methylsterol oxidase activity|iron ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|fatty acid metabolic process|cholesterol biosynthetic process|steroid metabolic process|membrane|integral component of membrane|sterol biosynthetic process|oxidoreductase activity|oxidation-reduction process hsa00100 Steroid biosynthesis MSN 16408.59632 15550.02589 17267.16675 1.110426881 0.151114398 0.569461125 1 180.3294876 196.8919199 4478 moesin "GO:0001771,GO:0001931,GO:0003725,GO:0003779,GO:0005102,GO:0005200,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005902,GO:0005925,GO:0007010,GO:0007159,GO:0008360,GO:0008361,GO:0009986,GO:0010628,GO:0016032,GO:0016323,GO:0016324,GO:0019899,GO:0019901,GO:0022612,GO:0022614,GO:0030175,GO:0031143,GO:0031528,GO:0031982,GO:0035722,GO:0042098,GO:0045177,GO:0045198,GO:0048471,GO:0050839,GO:0050900,GO:0061028,GO:0070062,GO:0070489,GO:0071394,GO:0071803,GO:0071944,GO:0072562,GO:0072678,GO:1902115,GO:1902966,GO:1903364,GO:2000401,GO:2000643" immunological synapse formation|uropod|double-stranded RNA binding|actin binding|signaling receptor binding|structural constituent of cytoskeleton|protein binding|extracellular space|nucleus|cytoplasm|cytosol|cytoskeleton|plasma membrane|microvillus|focal adhesion|cytoskeleton organization|leukocyte cell-cell adhesion|regulation of cell shape|regulation of cell size|cell surface|positive regulation of gene expression|viral process|basolateral plasma membrane|apical plasma membrane|enzyme binding|protein kinase binding|gland morphogenesis|membrane to membrane docking|filopodium|pseudopodium|microvillus membrane|vesicle|interleukin-12-mediated signaling pathway|T cell proliferation|apical part of cell|establishment of epithelial cell apical/basal polarity|perinuclear region of cytoplasm|cell adhesion molecule binding|leukocyte migration|establishment of endothelial barrier|extracellular exosome|T cell aggregation|cellular response to testosterone stimulus|positive regulation of podosome assembly|cell periphery|blood microparticle|T cell migration|regulation of organelle assembly|positive regulation of protein localization to early endosome|positive regulation of cellular protein catabolic process|regulation of lymphocyte migration|positive regulation of early endosome to late endosome transport "hsa04530,hsa04670,hsa04810,hsa05162,hsa05205" Tight junction|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Measles|Proteoglycans in cancer MSR1 500.4276726 432.8121752 568.04317 1.312447298 0.392259492 0.151266364 1 4.233575937 5.463367387 4481 macrophage scavenger receptor 1 "GO:0001540,GO:0005044,GO:0005515,GO:0005581,GO:0005886,GO:0005887,GO:0006898,GO:0006911,GO:0009897,GO:0010629,GO:0010744,GO:0010886,GO:0016021,GO:0030169,GO:0030301,GO:0030666,GO:0034362,GO:0034381,GO:0038024,GO:0097242" "amyloid-beta binding|scavenger receptor activity|protein binding|collagen trimer|plasma membrane|integral component of plasma membrane|receptor-mediated endocytosis|phagocytosis, engulfment|external side of plasma membrane|negative regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of cholesterol storage|integral component of membrane|low-density lipoprotein particle binding|cholesterol transport|endocytic vesicle membrane|low-density lipoprotein particle|plasma lipoprotein particle clearance|cargo receptor activity|amyloid-beta clearance" hsa04145 Phagosome MSRA 146.8480412 120.6880104 173.0080721 1.433514991 0.519556991 0.204874727 1 1.613451227 2.274203163 4482 methionine sulfoxide reductase A "GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006464,GO:0006555,GO:0006979,GO:0008113,GO:0015629,GO:0030091,GO:0034599,GO:0036456,GO:0055114,GO:0070062" protein binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|plasma membrane|cellular protein modification process|methionine metabolic process|response to oxidative stress|peptide-methionine (S)-S-oxide reductase activity|actin cytoskeleton|protein repair|cellular response to oxidative stress|L-methionine-(S)-S-oxide reductase activity|oxidation-reduction process|extracellular exosome MSRB1 274.096181 281.9521622 266.2401998 0.944274368 -0.082721985 0.808873029 1 11.78329576 10.94047451 51734 methionine sulfoxide reductase B1 "GO:0003779,GO:0005515,GO:0005575,GO:0005634,GO:0005829,GO:0008270,GO:0015629,GO:0030041,GO:0030091,GO:0033743,GO:0033745,GO:0045087,GO:0055114" actin binding|protein binding|cellular_component|nucleus|cytosol|zinc ion binding|actin cytoskeleton|actin filament polymerization|protein repair|peptide-methionine (R)-S-oxide reductase activity|L-methionine-(R)-S-oxide reductase activity|innate immune response|oxidation-reduction process MSRB2 171.9764903 174.7895323 169.1634483 0.967812237 -0.047200914 0.918115345 1 4.678132442 4.451791342 22921 methionine sulfoxide reductase B2 "GO:0003779,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0006979,GO:0008270,GO:0030041,GO:0030091,GO:0033743,GO:0033745,GO:0055114" actin binding|protein binding|cytoplasm|mitochondrion|cytosol|response to oxidative stress|zinc ion binding|actin filament polymerization|protein repair|peptide-methionine (R)-S-oxide reductase activity|L-methionine-(R)-S-oxide reductase activity|oxidation-reduction process MSRB3 2096.521717 1987.190516 2205.852919 1.110035953 0.150606405 0.524935067 1 19.94221616 21.76615129 253827 methionine sulfoxide reductase B3 "GO:0005515,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0006979,GO:0008270,GO:0030091,GO:0033743,GO:0033745,GO:0055114" protein binding|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|response to oxidative stress|zinc ion binding|protein repair|peptide-methionine (R)-S-oxide reductase activity|L-methionine-(R)-S-oxide reductase activity|oxidation-reduction process MSS51 70.02034581 59.30359131 80.7371003 1.361420085 0.445112299 0.40914267 1 1.306200443 1.748530284 118490 MSS51 mitochondrial translational activator "GO:0005515,GO:0046872" protein binding|metal ion binding MST1 108.6446072 114.4455271 102.8436873 0.89862566 -0.154207837 0.750105474 1 1.935894592 1.71053396 4485 macrophage stimulating 1 "GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0006508,GO:0010758,GO:0030971,GO:0033601,GO:0035978,GO:0045721,GO:0048012,GO:0062023,GO:2000479" serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|proteolysis|regulation of macrophage chemotaxis|receptor tyrosine kinase binding|positive regulation of mammary gland epithelial cell proliferation|histone H2A-S139 phosphorylation|negative regulation of gluconeogenesis|hepatocyte growth factor receptor signaling pathway|collagen-containing extracellular matrix|regulation of cAMP-dependent protein kinase activity hsa04020 Calcium signaling pathway MST1R 291.822846 318.3666481 265.2790439 0.833250108 -0.263178496 0.4096491 1 3.354519817 2.748380883 4486 macrophage stimulating 1 receptor "GO:0001725,GO:0004714,GO:0005011,GO:0005515,GO:0005524,GO:0005773,GO:0005886,GO:0005887,GO:0006909,GO:0006952,GO:0007165,GO:0007169,GO:0007275,GO:0007338,GO:0007399,GO:0008284,GO:0009615,GO:0009925,GO:0009986,GO:0016477,GO:0018108,GO:0019899,GO:0033674,GO:0038145,GO:0043235,GO:0043406,GO:0045087,GO:0048012,GO:0051897" stress fiber|transmembrane receptor protein tyrosine kinase activity|macrophage colony-stimulating factor receptor activity|protein binding|ATP binding|vacuole|plasma membrane|integral component of plasma membrane|phagocytosis|defense response|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|single fertilization|nervous system development|positive regulation of cell population proliferation|response to virus|basal plasma membrane|cell surface|cell migration|peptidyl-tyrosine phosphorylation|enzyme binding|positive regulation of kinase activity|macrophage colony-stimulating factor signaling pathway|receptor complex|positive regulation of MAP kinase activity|innate immune response|hepatocyte growth factor receptor signaling pathway|positive regulation of protein kinase B signaling hsa04020 Calcium signaling pathway MSTO1 282.057801 301.720026 262.395576 0.869665761 -0.201467059 0.53641075 1 5.667808253 4.846616985 55154 misato mitochondrial distribution and morphology regulator 1 "GO:0003674,GO:0005515,GO:0005737,GO:0005741,GO:0005829,GO:0007005,GO:0048311" molecular_function|protein binding|cytoplasm|mitochondrial outer membrane|cytosol|mitochondrion organization|mitochondrion distribution MSX1 271.4605478 263.2247123 279.6963832 1.062576461 0.087566658 0.798007655 1 7.241143871 7.565515854 4487 msh homeobox 1 "GO:0000122,GO:0000785,GO:0000902,GO:0000977,GO:0000981,GO:0000987,GO:0001227,GO:0001228,GO:0001701,GO:0002039,GO:0003198,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007517,GO:0008285,GO:0009952,GO:0010463,GO:0021983,GO:0023019,GO:0030308,GO:0030513,GO:0030901,GO:0034504,GO:0035115,GO:0035116,GO:0035880,GO:0042474,GO:0042475,GO:0042481,GO:0043066,GO:0043517,GO:0045944,GO:0048598,GO:0048863,GO:0050821,GO:0051154,GO:0060021,GO:0060325,GO:0060349,GO:0060536,GO:0061180,GO:0061312,GO:0071316,GO:0090427,GO:1902255,GO:1990837,GO:2000678,GO:2001055" "negative regulation of transcription by RNA polymerase II|chromatin|cell morphogenesis|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|in utero embryonic development|p53 binding|epithelial to mesenchymal transition involved in endocardial cushion formation|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|muscle organ development|negative regulation of cell population proliferation|anterior/posterior pattern specification|mesenchymal cell proliferation|pituitary gland development|signal transduction involved in regulation of gene expression|negative regulation of cell growth|positive regulation of BMP signaling pathway|midbrain development|protein localization to nucleus|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic nail plate morphogenesis|middle ear morphogenesis|odontogenesis of dentin-containing tooth|regulation of odontogenesis|negative regulation of apoptotic process|positive regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of transcription by RNA polymerase II|embryonic morphogenesis|stem cell differentiation|protein stabilization|negative regulation of striated muscle cell differentiation|roof of mouth development|face morphogenesis|bone morphogenesis|cartilage morphogenesis|mammary gland epithelium development|BMP signaling pathway involved in heart development|cellular response to nicotine|activation of meiosis|positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator|sequence-specific double-stranded DNA binding|negative regulation of transcription regulatory region DNA binding|positive regulation of mesenchymal cell apoptotic process" hsa05166 Human T-cell leukemia virus 1 infection Homeobox MT1E 2218.841389 1955.978099 2481.704678 1.268779379 0.343441229 0.146368966 1 262.2787845 327.2053926 4493 metallothionein 1E "GO:0005515,GO:0005634,GO:0005737,GO:0006882,GO:0008270,GO:0010273,GO:0045926,GO:0046872,GO:0071276,GO:0071280,GO:0071294" protein binding|nucleus|cytoplasm|cellular zinc ion homeostasis|zinc ion binding|detoxification of copper ion|negative regulation of growth|metal ion binding|cellular response to cadmium ion|cellular response to copper ion|cellular response to zinc ion hsa04978 Mineral absorption MT1F 99.12236639 91.55642167 106.6883111 1.165273928 0.220669138 0.651881478 1 11.49693636 13.17289819 4494 metallothionein 1F "GO:0005515,GO:0005634,GO:0005737,GO:0006882,GO:0008270,GO:0010273,GO:0045926,GO:0046872,GO:0071276,GO:0071280,GO:0071294" protein binding|nucleus|cytoplasm|cellular zinc ion homeostasis|zinc ion binding|detoxification of copper ion|negative regulation of growth|metal ion binding|cellular response to cadmium ion|cellular response to copper ion|cellular response to zinc ion hsa04978 Mineral absorption MT1M 21.54172067 10.40413883 32.6793025 3.140990624 1.651219636 0.050938487 1 1.395099918 4.308668996 4499 metallothionein 1M "GO:0005515,GO:0005634,GO:0005737,GO:0006882,GO:0008270,GO:0010273,GO:0045926,GO:0046872,GO:0071276,GO:0071280,GO:0071294" protein binding|nucleus|cytoplasm|cellular zinc ion homeostasis|zinc ion binding|detoxification of copper ion|negative regulation of growth|metal ion binding|cellular response to cadmium ion|cellular response to copper ion|cellular response to zinc ion hsa04978 Mineral absorption MT1X 84.1105926 75.95021343 92.27097178 1.21488759 0.280822832 0.584922542 1 10.03297847 11.98497561 4501 metallothionein 1X "GO:0005515,GO:0005634,GO:0005737,GO:0006882,GO:0008270,GO:0010038,GO:0010273,GO:0036018,GO:0045926,GO:0046872,GO:0071276,GO:0071280,GO:0071294" protein binding|nucleus|cytoplasm|cellular zinc ion homeostasis|zinc ion binding|response to metal ion|detoxification of copper ion|cellular response to erythropoietin|negative regulation of growth|metal ion binding|cellular response to cadmium ion|cellular response to copper ion|cellular response to zinc ion hsa04978 Mineral absorption MT2A 9752.127142 7160.12834 12344.12594 1.724009034 0.785767334 0.001826633 0.268593592 952.9249121 1615.360268 4502 metallothionein 2A "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006878,GO:0006882,GO:0008270,GO:0010038,GO:0010273,GO:0036016,GO:0036018,GO:0045926,GO:0046872,GO:0060333,GO:0071276,GO:0071280,GO:0071294" protein binding|nucleus|cytoplasm|cytosol|cellular copper ion homeostasis|cellular zinc ion homeostasis|zinc ion binding|response to metal ion|detoxification of copper ion|cellular response to interleukin-3|cellular response to erythropoietin|negative regulation of growth|metal ion binding|interferon-gamma-mediated signaling pathway|cellular response to cadmium ion|cellular response to copper ion|cellular response to zinc ion hsa04978 Mineral absorption MTA1 2034.644816 2192.152051 1877.137582 0.856298988 -0.223813475 0.344292997 1 25.70103821 21.63950273 9112 metastasis associated 1 "GO:0000122,GO:0000978,GO:0001103,GO:0003682,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005829,GO:0005874,GO:0006302,GO:0007165,GO:0008270,GO:0010212,GO:0016575,GO:0016581,GO:0032922,GO:0040029,GO:0042826,GO:0043153,GO:0043161,GO:0043231,GO:0045475,GO:0045893,GO:1902499" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II repressing transcription factor binding|chromatin binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|cytosol|microtubule|double-strand break repair|signal transduction|zinc ion binding|response to ionizing radiation|histone deacetylation|NuRD complex|circadian regulation of gene expression|regulation of gene expression, epigenetic|histone deacetylase binding|entrainment of circadian clock by photoperiod|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|locomotor rhythm|positive regulation of transcription, DNA-templated|positive regulation of protein autoubiquitination" MTA2 2156.285765 2155.737565 2156.833965 1.000508596 0.000733563 0.999792855 1 34.74713131 34.18306167 9219 metastasis associated 1 family member 2 "GO:0000118,GO:0000122,GO:0000785,GO:0001085,GO:0001103,GO:0003713,GO:0003714,GO:0004407,GO:0005515,GO:0005654,GO:0005667,GO:0006306,GO:0006333,GO:0008270,GO:0010762,GO:0016020,GO:0016575,GO:0016581,GO:0031492,GO:0032991,GO:0042826,GO:0043044,GO:0043565,GO:0045944,GO:1901796" histone deacetylase complex|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription factor binding|RNA polymerase II repressing transcription factor binding|transcription coactivator activity|transcription corepressor activity|histone deacetylase activity|protein binding|nucleoplasm|transcription regulator complex|DNA methylation|chromatin assembly or disassembly|zinc ion binding|regulation of fibroblast migration|membrane|histone deacetylation|NuRD complex|nucleosomal DNA binding|protein-containing complex|histone deacetylase binding|ATP-dependent chromatin remodeling|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|regulation of signal transduction by p53 class mediator MTA3 797.1305258 765.7446176 828.5164341 1.081974871 0.113666993 0.654732748 1 4.528131065 4.817340474 57504 metastasis associated 1 family member 3 "GO:0000122,GO:0001103,GO:0003682,GO:0003713,GO:0003714,GO:0005515,GO:0005654,GO:0005737,GO:0008270,GO:0008284,GO:0010971,GO:0016575,GO:0016581,GO:0042826,GO:0043231,GO:0043565,GO:0044877,GO:0045892,GO:0045893" "negative regulation of transcription by RNA polymerase II|RNA polymerase II repressing transcription factor binding|chromatin binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleoplasm|cytoplasm|zinc ion binding|positive regulation of cell population proliferation|positive regulation of G2/M transition of mitotic cell cycle|histone deacetylation|NuRD complex|histone deacetylase binding|intracellular membrane-bounded organelle|sequence-specific DNA binding|protein-containing complex binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated" zf-GATA MTAP 1834.12234 1797.835189 1870.40949 1.040367605 0.057093383 0.811563167 1 15.90635938 16.27154493 4507 methylthioadenosine phosphorylase "GO:0004645,GO:0005515,GO:0005654,GO:0005829,GO:0006139,GO:0006166,GO:0006738,GO:0017061,GO:0019509,GO:0033574,GO:0035722,GO:0070062" "1,4-alpha-oligoglucan phosphorylase activity|protein binding|nucleoplasm|cytosol|nucleobase-containing compound metabolic process|purine ribonucleoside salvage|nicotinamide riboside catabolic process|S-methyl-5-thioadenosine phosphorylase activity|L-methionine salvage from methylthioadenosine|response to testosterone|interleukin-12-mediated signaling pathway|extracellular exosome" hsa00270 Cysteine and methionine metabolism MTARC1 219.9644766 248.658918 191.2700352 0.769206417 -0.378557297 0.281588338 1 3.999538709 3.024990265 64757 mitochondrial amidoxime reducing component 1 "GO:0005515,GO:0005739,GO:0005741,GO:0006805,GO:0006809,GO:0008940,GO:0016021,GO:0016661,GO:0030151,GO:0030170,GO:0042126,GO:0043546,GO:0050421,GO:0051410,GO:0055114,GO:0070458,GO:0098809,GO:1903958" "protein binding|mitochondrion|mitochondrial outer membrane|xenobiotic metabolic process|nitric oxide biosynthetic process|nitrate reductase activity|integral component of membrane|oxidoreductase activity, acting on other nitrogenous compounds as donors|molybdenum ion binding|pyridoxal phosphate binding|nitrate metabolic process|molybdopterin cofactor binding|nitrite reductase (NO-forming) activity|detoxification of nitrogen compound|oxidation-reduction process|cellular detoxification of nitrogen compound|nitrite reductase activity|nitric-oxide synthase complex" MTARC2 339.1918601 338.1345119 340.2492084 1.00625401 0.008994532 0.987413575 1 8.099469225 8.013742108 54996 mitochondrial amidoxime reducing component 2 "GO:0005739,GO:0005741,GO:0005777,GO:0006805,GO:0006809,GO:0008940,GO:0016661,GO:0030151,GO:0030170,GO:0042126,GO:0043546,GO:0051410,GO:0055114,GO:0070458,GO:0098809" "mitochondrion|mitochondrial outer membrane|peroxisome|xenobiotic metabolic process|nitric oxide biosynthetic process|nitrate reductase activity|oxidoreductase activity, acting on other nitrogenous compounds as donors|molybdenum ion binding|pyridoxal phosphate binding|nitrate metabolic process|molybdopterin cofactor binding|detoxification of nitrogen compound|oxidation-reduction process|cellular detoxification of nitrogen compound|nitrite reductase activity" MTBP 535.7967142 516.0452858 555.5481426 1.076549206 0.106414262 0.697415748 1 5.757973751 6.095014515 27085 MDM2 binding protein "GO:0000776,GO:0000785,GO:0007050,GO:0007089,GO:0008285,GO:0031396,GO:0034501,GO:0045839" kinetochore|chromatin|cell cycle arrest|traversing start control point of mitotic cell cycle|negative regulation of cell population proliferation|regulation of protein ubiquitination|protein localization to kinetochore|negative regulation of mitotic nuclear division MTCH1 4279.663171 3687.2268 4872.099541 1.321345229 0.40200745 0.09230315 1 66.18920871 85.99529065 23787 mitochondrial carrier 1 "GO:0005515,GO:0005739,GO:0005743,GO:0006915,GO:0006919,GO:0009966,GO:0016020,GO:0016021,GO:0043065,GO:0045161" protein binding|mitochondrion|mitochondrial inner membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of signal transduction|membrane|integral component of membrane|positive regulation of apoptotic process|neuronal ion channel clustering MTCH2 1941.890079 1901.876577 1981.903581 1.042077916 0.059463152 0.803463436 1 22.70685849 23.26635897 23788 mitochondrial carrier 2 "GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0016020,GO:0016021,GO:0043065,GO:0070585" protein binding|nucleus|mitochondrion|mitochondrial inner membrane|membrane|integral component of membrane|positive regulation of apoptotic process|protein localization to mitochondrion MTCL1 833.3412221 946.7766332 719.905811 0.760375558 -0.395215937 0.11437681 1 3.95489424 2.956883414 23255 microtubule crosslinking factor 1 "GO:0000922,GO:0001578,GO:0003723,GO:0005615,GO:0005737,GO:0005856,GO:0008017,GO:0010506,GO:0016324,GO:0016327,GO:0016328,GO:0030496,GO:0042803,GO:0045197,GO:0090314,GO:0097427,GO:2000576" spindle pole|microtubule bundle formation|RNA binding|extracellular space|cytoplasm|cytoskeleton|microtubule binding|regulation of autophagy|apical plasma membrane|apicolateral plasma membrane|lateral plasma membrane|midbody|protein homodimerization activity|establishment or maintenance of epithelial cell apical/basal polarity|positive regulation of protein targeting to membrane|microtubule bundle|positive regulation of microtubule motor activity MTCP1 107.8469975 106.122216 109.571779 1.032505568 0.046149562 0.941230034 1 2.593199462 2.632688667 4515 mature T cell proliferation 1 "GO:0019901,GO:0032991,GO:0033138,GO:0043539,GO:0071902" protein kinase binding|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|protein serine/threonine kinase activator activity|positive regulation of protein serine/threonine kinase activity hsa04151 PI3K-Akt signaling pathway MTDH 5043.164643 5021.037398 5065.291888 1.008813814 0.012659936 0.958842924 1 33.64685304 33.37541315 92140 metadherin "GO:0000122,GO:0001085,GO:0001650,GO:0003712,GO:0003713,GO:0003723,GO:0003725,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0005923,GO:0006357,GO:0010508,GO:0016021,GO:0016324,GO:0016604,GO:0031663,GO:0031965,GO:0043066,GO:0043123,GO:0045766,GO:0045893,GO:0046581,GO:0048471,GO:0051059,GO:0051092,GO:0051897,GO:0070830" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription factor binding|fibrillar center|transcription coregulator activity|transcription coactivator activity|RNA binding|double-stranded RNA binding|protein binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|bicellular tight junction|regulation of transcription by RNA polymerase II|positive regulation of autophagy|integral component of membrane|apical plasma membrane|nuclear body|lipopolysaccharide-mediated signaling pathway|nuclear membrane|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of angiogenesis|positive regulation of transcription, DNA-templated|intercellular canaliculus|perinuclear region of cytoplasm|NF-kappaB binding|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling|bicellular tight junction assembly" MTERF1 191.4770121 182.0724295 200.8815948 1.10330595 0.14183291 0.711502636 1 2.406357337 2.610521403 7978 mitochondrial transcription termination factor 1 "GO:0003676,GO:0003690,GO:0003723,GO:0005515,GO:0005739,GO:0005759,GO:0006353,GO:0006355,GO:0006393,GO:0007005,GO:0032392,GO:0042645" "nucleic acid binding|double-stranded DNA binding|RNA binding|protein binding|mitochondrion|mitochondrial matrix|DNA-templated transcription, termination|regulation of transcription, DNA-templated|termination of mitochondrial transcription|mitochondrion organization|DNA geometric change|mitochondrial nucleoid" MTERF2 122.8984003 122.7688382 123.0279624 1.002110668 0.003041841 1 1 1.038837364 1.023609777 80298 mitochondrial transcription termination factor 2 "GO:0003676,GO:0003677,GO:0003690,GO:0005515,GO:0005739,GO:0005759,GO:0006355,GO:0006393,GO:0042645" "nucleic acid binding|DNA binding|double-stranded DNA binding|protein binding|mitochondrion|mitochondrial matrix|regulation of transcription, DNA-templated|termination of mitochondrial transcription|mitochondrial nucleoid" MTERF3 706.7327906 688.7539903 724.7115908 1.05220674 0.073418197 0.778727995 1 22.23686303 23.00624704 51001 mitochondrial transcription termination factor 3 "GO:0000976,GO:0005515,GO:0005739,GO:0005741,GO:0005829,GO:0016236,GO:0045892,GO:0061668" "transcription regulatory region sequence-specific DNA binding|protein binding|mitochondrion|mitochondrial outer membrane|cytosol|macroautophagy|negative regulation of transcription, DNA-templated|mitochondrial ribosome assembly" MTERF4 548.5936821 561.8234966 535.3638675 0.952904018 -0.06959719 0.80075885 1 3.837149658 3.595249834 130916 mitochondrial transcription termination factor 4 "GO:0003690,GO:0005515,GO:0005739,GO:0005759,GO:0005762,GO:0005829,GO:0006355,GO:0006390,GO:0006626,GO:0007507,GO:0019843,GO:0031167,GO:0042255,GO:0043010" "double-stranded DNA binding|protein binding|mitochondrion|mitochondrial matrix|mitochondrial large ribosomal subunit|cytosol|regulation of transcription, DNA-templated|mitochondrial transcription|protein targeting to mitochondrion|heart development|rRNA binding|rRNA methylation|ribosome assembly|camera-type eye development" MTF1 354.1489137 390.155206 318.1426214 0.815425801 -0.294374488 0.326675907 1 2.346919102 1.881714568 4520 metal regulatory transcription factor 1 "GO:0000978,GO:0000981,GO:0000987,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0006357,GO:0006979,GO:0007417,GO:0010038,GO:0035035,GO:0045944,GO:0046686,GO:0046872,GO:0071294,GO:1990079,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|response to oxidative stress|central nervous system development|response to metal ion|histone acetyltransferase binding|positive regulation of transcription by RNA polymerase II|response to cadmium ion|metal ion binding|cellular response to zinc ion|cartilage homeostasis|sequence-specific double-stranded DNA binding" MTF2 603.1367674 568.0659799 638.2075548 1.123474345 0.167967181 0.525321954 1 7.588645128 8.382982941 22823 metal response element binding transcription factor 2 "GO:0000122,GO:0000977,GO:0001226,GO:0003677,GO:0003682,GO:0005634,GO:0005654,GO:0005737,GO:0005925,GO:0006325,GO:0006355,GO:0007379,GO:0019827,GO:0035064,GO:0035098,GO:0045814,GO:0045944,GO:0046872,GO:0048863,GO:0061086,GO:0061087,GO:1990830" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription corepressor binding|DNA binding|chromatin binding|nucleus|nucleoplasm|cytoplasm|focal adhesion|chromatin organization|regulation of transcription, DNA-templated|segment specification|stem cell population maintenance|methylated histone binding|ESC/E(Z) complex|negative regulation of gene expression, epigenetic|positive regulation of transcription by RNA polymerase II|metal ion binding|stem cell differentiation|negative regulation of histone H3-K27 methylation|positive regulation of histone H3-K27 methylation|cellular response to leukemia inhibitory factor" MTFMT 283.9159462 262.1842984 305.647594 1.165773831 0.221287922 0.495485788 1 4.826593354 5.532560749 123263 mitochondrial methionyl-tRNA formyltransferase "GO:0004479,GO:0005739,GO:0006413,GO:0071951" methionyl-tRNA formyltransferase activity|mitochondrion|translational initiation|conversion of methionyl-tRNA to N-formyl-methionyl-tRNA "hsa00670,hsa00970" One carbon pool by folate|Aminoacyl-tRNA biosynthesis MTFP1 431.6257638 430.7313474 432.5201802 1.004153013 0.005979124 0.992538746 1 20.28891471 20.03225734 51537 mitochondrial fission process 1 "GO:0000266,GO:0005515,GO:0005739,GO:0005743,GO:0006915,GO:0014850,GO:0016021" mitochondrial fission|protein binding|mitochondrion|mitochondrial inner membrane|apoptotic process|response to muscle activity|integral component of membrane MTFR1 1203.692007 1181.910171 1225.473844 1.036858701 0.052219302 0.832282153 1 17.67835582 18.02323003 9650 mitochondrial fission regulator 1 "GO:0000266,GO:0005515,GO:0005739,GO:0005829,GO:0005886,GO:0007005,GO:0009060" mitochondrial fission|protein binding|mitochondrion|cytosol|plasma membrane|mitochondrion organization|aerobic respiration MTFR1L 601.0163106 562.8639105 639.1687107 1.135565274 0.183410637 0.487761872 1 12.9089009 14.41360276 56181 mitochondrial fission regulator 1 like "GO:0000266,GO:0005515,GO:0005739,GO:0009060" mitochondrial fission|protein binding|mitochondrion|aerobic respiration MTFR2 304.0304098 336.0536841 272.0071355 0.809415723 -0.305047222 0.331833027 1 9.474150808 7.540204215 113115 mitochondrial fission regulator 2 "GO:0000266,GO:0005515,GO:0005739,GO:0007005,GO:0009060" mitochondrial fission|protein binding|mitochondrion|mitochondrion organization|aerobic respiration MTG1 221.0099209 238.2547791 203.7650627 0.85524019 -0.225598443 0.52477712 1 3.713557146 3.122837541 92170 mitochondrial ribosome associated GTPase 1 "GO:0003924,GO:0005515,GO:0005525,GO:0005739,GO:0005743,GO:0005759,GO:0005761,GO:0044065,GO:0070129" GTPase activity|protein binding|GTP binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|mitochondrial ribosome|regulation of respiratory system process|regulation of mitochondrial translation MTG2 1042.540483 1076.828369 1008.252598 0.936316898 -0.0949312 0.700957835 1 7.52597576 6.928781326 26164 mitochondrial ribosome associated GTPase 2 "GO:0000287,GO:0003924,GO:0005525,GO:0005739,GO:0005743,GO:0005759,GO:0005761,GO:0042254,GO:0044065,GO:0070129" magnesium ion binding|GTPase activity|GTP binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|mitochondrial ribosome|ribosome biogenesis|regulation of respiratory system process|regulation of mitochondrial translation MTHFD1 3343.142452 3375.102635 3311.182268 0.981061208 -0.027584947 0.908628679 1 57.10939267 55.09026024 4522 "methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1" "GO:0000105,GO:0001843,GO:0004329,GO:0004477,GO:0004486,GO:0004487,GO:0004488,GO:0005515,GO:0005524,GO:0005739,GO:0005829,GO:0006164,GO:0006555,GO:0006730,GO:0007507,GO:0009069,GO:0009070,GO:0009086,GO:0009257,GO:0016020,GO:0035999,GO:0046655,GO:0048702,GO:0048703,GO:0055114,GO:0061053,GO:0070062" histidine biosynthetic process|neural tube closure|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding|ATP binding|mitochondrion|cytosol|purine nucleotide biosynthetic process|methionine metabolic process|one-carbon metabolic process|heart development|serine family amino acid metabolic process|serine family amino acid biosynthetic process|methionine biosynthetic process|10-formyltetrahydrofolate biosynthetic process|membrane|tetrahydrofolate interconversion|folic acid metabolic process|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|oxidation-reduction process|somite development|extracellular exosome hsa00670 One carbon pool by folate MTHFD1L 1155.371284 1238.09252 1072.650047 0.866373093 -0.206939656 0.394802645 1 4.969892613 4.23372982 25902 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like "GO:0001843,GO:0004329,GO:0004488,GO:0005524,GO:0005739,GO:0005759,GO:0005829,GO:0006760,GO:0009257,GO:0015942,GO:0016020,GO:0035999,GO:0042803,GO:0046655,GO:0048702,GO:0048703,GO:0055114" neural tube closure|formate-tetrahydrofolate ligase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|ATP binding|mitochondrion|mitochondrial matrix|cytosol|folic acid-containing compound metabolic process|10-formyltetrahydrofolate biosynthetic process|formate metabolic process|membrane|tetrahydrofolate interconversion|protein homodimerization activity|folic acid metabolic process|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|oxidation-reduction process hsa00670 One carbon pool by folate MTHFD2 3581.809841 3622.721139 3540.898542 0.97741405 -0.032958251 0.890722531 1 43.6724574 41.97177985 10797 "methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase" "GO:0000287,GO:0004477,GO:0004487,GO:0004488,GO:0005515,GO:0005615,GO:0005739,GO:0005759,GO:0035999,GO:0042301,GO:0046653,GO:0046655,GO:0055114" magnesium ion binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding|extracellular space|mitochondrion|mitochondrial matrix|tetrahydrofolate interconversion|phosphate ion binding|tetrahydrofolate metabolic process|folic acid metabolic process|oxidation-reduction process hsa00670 One carbon pool by folate MTHFD2L 203.2882863 189.3553266 217.2212461 1.147162057 0.198069212 0.590899231 1 1.205624644 1.35990343 441024 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like "GO:0000105,GO:0004477,GO:0004487,GO:0004488,GO:0005739,GO:0005743,GO:0005759,GO:0006164,GO:0009086,GO:0009256,GO:0035999,GO:0046655,GO:0055114" histidine biosynthetic process|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|purine nucleotide biosynthetic process|methionine biosynthetic process|10-formyltetrahydrofolate metabolic process|tetrahydrofolate interconversion|folic acid metabolic process|oxidation-reduction process hsa00670 One carbon pool by folate MTHFR 296.6336562 305.8816815 287.3856308 0.939532009 -0.089985781 0.784585783 1 2.114004553 1.952938997 4524 methylenetetrahydrofolate reductase "GO:0001666,GO:0001843,GO:0004489,GO:0005829,GO:0006555,GO:0009086,GO:0031060,GO:0033274,GO:0035999,GO:0042493,GO:0043200,GO:0044877,GO:0045202,GO:0046500,GO:0046655,GO:0050660,GO:0050661,GO:0050667,GO:0051593,GO:0055114,GO:0070555,GO:0070829,GO:0071949,GO:0072341" response to hypoxia|neural tube closure|methylenetetrahydrofolate reductase (NAD(P)H) activity|cytosol|methionine metabolic process|methionine biosynthetic process|regulation of histone methylation|response to vitamin B2|tetrahydrofolate interconversion|response to drug|response to amino acid|protein-containing complex binding|synapse|S-adenosylmethionine metabolic process|folic acid metabolic process|flavin adenine dinucleotide binding|NADP binding|homocysteine metabolic process|response to folic acid|oxidation-reduction process|response to interleukin-1|heterochromatin maintenance|FAD binding|modified amino acid binding "hsa00670,hsa01523" One carbon pool by folate|Antifolate resistance MTHFS 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.062370287 10588 methenyltetrahydrofolate synthetase "GO:0005524,GO:0005542,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006536,GO:0009396,GO:0015942,GO:0030272,GO:0035999,GO:0046653,GO:0046655,GO:0046657,GO:0046872" ATP binding|folic acid binding|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|glutamate metabolic process|folic acid-containing compound biosynthetic process|formate metabolic process|5-formyltetrahydrofolate cyclo-ligase activity|tetrahydrofolate interconversion|tetrahydrofolate metabolic process|folic acid metabolic process|folic acid catabolic process|metal ion binding hsa00670 One carbon pool by folate MTHFSD 379.2131961 404.7210003 353.7053918 0.873948699 -0.194379499 0.511406106 1 3.621598917 3.11212814 64779 methenyltetrahydrofolate synthetase domain containing "GO:0003723,GO:0005737" RNA binding|cytoplasm MTIF2 736.2009183 806.320759 666.0810775 0.826074574 -0.275656068 0.278866057 1 8.257888497 6.707480953 4528 mitochondrial translational initiation factor 2 "GO:0003723,GO:0003743,GO:0003924,GO:0005525,GO:0005654,GO:0005739,GO:0006446,GO:0008135,GO:0032790,GO:0043024,GO:0070124" "RNA binding|translation initiation factor activity|GTPase activity|GTP binding|nucleoplasm|mitochondrion|regulation of translational initiation|translation factor activity, RNA binding|ribosome disassembly|ribosomal small subunit binding|mitochondrial translational initiation" MTIF3 451.5080984 384.9531366 518.0630603 1.345782151 0.428444892 0.126236799 1 12.27254563 16.23979707 219402 mitochondrial translational initiation factor 3 "GO:0003743,GO:0005515,GO:0005739,GO:0008135,GO:0032790,GO:0043022,GO:0043024,GO:0070124" "translation initiation factor activity|protein binding|mitochondrion|translation factor activity, RNA binding|ribosome disassembly|ribosome binding|ribosomal small subunit binding|mitochondrial translational initiation" MTLN 228.7935177 202.8807071 254.7063283 1.255448741 0.328203126 0.344911493 1 25.35683948 31.30150978 205251 mitoregulin "GO:0010918,GO:0031305,GO:0031334,GO:0051284" positive regulation of mitochondrial membrane potential|integral component of mitochondrial inner membrane|positive regulation of protein-containing complex assembly|positive regulation of sequestering of calcium ion MTM1 457.180685 420.3272086 494.0341614 1.17535613 0.233097957 0.406011764 1 2.613548945 3.020447512 4534 myotubularin 1 "GO:0001726,GO:0004438,GO:0004721,GO:0004725,GO:0005515,GO:0005737,GO:0005770,GO:0005829,GO:0005886,GO:0006470,GO:0006661,GO:0008333,GO:0015031,GO:0016020,GO:0019215,GO:0030175,GO:0031674,GO:0032007,GO:0032435,GO:0035091,GO:0035335,GO:0044088,GO:0045109,GO:0046716,GO:0046856,GO:0048311,GO:0048633,GO:0051898,GO:0052629,GO:0070584,GO:1902902" "ruffle|phosphatidylinositol-3-phosphatase activity|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|cytoplasm|late endosome|cytosol|plasma membrane|protein dephosphorylation|phosphatidylinositol biosynthetic process|endosome to lysosome transport|protein transport|membrane|intermediate filament binding|filopodium|I band|negative regulation of TOR signaling|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|phosphatidylinositol binding|peptidyl-tyrosine dephosphorylation|regulation of vacuole organization|intermediate filament organization|muscle cell cellular homeostasis|phosphatidylinositol dephosphorylation|mitochondrion distribution|positive regulation of skeletal muscle tissue growth|negative regulation of protein kinase B signaling|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|mitochondrion morphogenesis|negative regulation of autophagosome assembly" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system MTMR1 2464.433171 2511.559113 2417.307229 0.962472759 -0.055182386 0.81682536 1 17.80753206 16.85246213 8776 myotubularin related protein 1 "GO:0004438,GO:0004725,GO:0005737,GO:0005829,GO:0005886,GO:0006661,GO:0016020,GO:0035335,GO:0042803,GO:0046856,GO:0052629,GO:0060304" "phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity|cytoplasm|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|membrane|peptidyl-tyrosine dephosphorylation|protein homodimerization activity|phosphatidylinositol dephosphorylation|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|regulation of phosphatidylinositol dephosphorylation" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system MTMR10 513.4328461 458.8225222 568.04317 1.238045524 0.308064365 0.257447755 1 4.289107503 5.22125284 54893 myotubularin related protein 10 "GO:0004438,GO:0005737,GO:0005829,GO:0016020,GO:0046856" phosphatidylinositol-3-phosphatase activity|cytoplasm|cytosol|membrane|phosphatidylinositol dephosphorylation MTMR11 590.1561315 580.5509465 599.7613165 1.033089895 0.046965797 0.864893483 1 11.16904723 11.34554649 10903 myotubularin related protein 11 "GO:0004438,GO:0005737,GO:0016020,GO:0046856,GO:0070062" phosphatidylinositol-3-phosphatase activity|cytoplasm|membrane|phosphatidylinositol dephosphorylation|extracellular exosome MTMR12 1101.116891 1012.322708 1189.911074 1.175426635 0.233184495 0.339399695 1 10.56016465 12.20498909 54545 myotubularin related protein 12 "GO:0004438,GO:0005515,GO:0005737,GO:0005829,GO:0006661,GO:0016020,GO:0016529,GO:0019208,GO:0030017,GO:0046856,GO:0050790,GO:1901998" phosphatidylinositol-3-phosphatase activity|protein binding|cytoplasm|cytosol|phosphatidylinositol biosynthetic process|membrane|sarcoplasmic reticulum|phosphatase regulator activity|sarcomere|phosphatidylinositol dephosphorylation|regulation of catalytic activity|toxin transport MTMR14 993.6907205 955.0999443 1032.281497 1.080809922 0.112112825 0.651020846 1 17.71088555 18.82178371 64419 myotubularin related protein 14 "GO:0001726,GO:0004438,GO:0004725,GO:0005515,GO:0005829,GO:0006661,GO:0016236,GO:0035335,GO:0048471" ruffle|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity|protein binding|cytosol|phosphatidylinositol biosynthetic process|macroautophagy|peptidyl-tyrosine dephosphorylation|perinuclear region of cytoplasm "hsa00562,hsa04070,hsa04140" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Autophagy - animal MTMR2 1223.405765 1156.940237 1289.871293 1.114898809 0.156912774 0.51760783 1 12.50127032 13.70442367 8898 myotubularin related protein 2 "GO:0002091,GO:0004438,GO:0004725,GO:0005515,GO:0005634,GO:0005737,GO:0005774,GO:0005829,GO:0006470,GO:0006661,GO:0008021,GO:0008138,GO:0014069,GO:0016020,GO:0030424,GO:0030425,GO:0031642,GO:0031901,GO:0032288,GO:0035335,GO:0042802,GO:0043197,GO:0043231,GO:0045806,GO:0046855,GO:0046856,GO:0048471,GO:0048666,GO:0052629,GO:0060304,GO:0070062,GO:0090394,GO:0097060,GO:0097062,GO:2000643,GO:2000645" "negative regulation of receptor internalization|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|vacuolar membrane|cytosol|protein dephosphorylation|phosphatidylinositol biosynthetic process|synaptic vesicle|protein tyrosine/serine/threonine phosphatase activity|postsynaptic density|membrane|axon|dendrite|negative regulation of myelination|early endosome membrane|myelin assembly|peptidyl-tyrosine dephosphorylation|identical protein binding|dendritic spine|intracellular membrane-bounded organelle|negative regulation of endocytosis|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|perinuclear region of cytoplasm|neuron development|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|regulation of phosphatidylinositol dephosphorylation|extracellular exosome|negative regulation of excitatory postsynaptic potential|synaptic membrane|dendritic spine maintenance|positive regulation of early endosome to late endosome transport|negative regulation of receptor catabolic process" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system MTMR3 1664.512912 1811.36057 1517.665255 0.837859275 -0.255220142 0.282932299 1 10.724316 8.835108005 8897 myotubularin related protein 3 "GO:0004438,GO:0004722,GO:0004725,GO:0005515,GO:0005737,GO:0005829,GO:0006470,GO:0006661,GO:0010506,GO:0016020,GO:0016236,GO:0019898,GO:0019903,GO:0035335,GO:0042149,GO:0046856,GO:0046872,GO:0052629,GO:0060304,GO:1904562,GO:2000785" "phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein binding|cytoplasm|cytosol|protein dephosphorylation|phosphatidylinositol biosynthetic process|regulation of autophagy|membrane|macroautophagy|extrinsic component of membrane|protein phosphatase binding|peptidyl-tyrosine dephosphorylation|cellular response to glucose starvation|phosphatidylinositol dephosphorylation|metal ion binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|regulation of phosphatidylinositol dephosphorylation|phosphatidylinositol 5-phosphate metabolic process|regulation of autophagosome assembly" "hsa00562,hsa04070,hsa04140" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Autophagy - animal MTMR4 1573.868571 1551.257099 1596.480043 1.029152449 0.041456706 0.864303411 1 12.6354915 12.78624525 9110 myotubularin related protein 4 "GO:0004438,GO:0004722,GO:0004725,GO:0005515,GO:0005615,GO:0005737,GO:0005768,GO:0005829,GO:0006470,GO:0006661,GO:0007179,GO:0010506,GO:0014894,GO:0016020,GO:0019903,GO:0030512,GO:0031901,GO:0035335,GO:0046856,GO:0046872,GO:0052629,GO:0060304" "phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein binding|extracellular space|cytoplasm|endosome|cytosol|protein dephosphorylation|phosphatidylinositol biosynthetic process|transforming growth factor beta receptor signaling pathway|regulation of autophagy|response to denervation involved in regulation of muscle adaptation|membrane|protein phosphatase binding|negative regulation of transforming growth factor beta receptor signaling pathway|early endosome membrane|peptidyl-tyrosine dephosphorylation|phosphatidylinositol dephosphorylation|metal ion binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|regulation of phosphatidylinositol dephosphorylation" "hsa00562,hsa04070,hsa04140" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Autophagy - animal MTMR6 1693.25447 1644.894348 1741.614592 1.058800277 0.082430478 0.73029429 1 16.51335369 17.19176665 9107 myotubularin related protein 6 "GO:0004438,GO:0004722,GO:0004725,GO:0005515,GO:0005635,GO:0005737,GO:0005783,GO:0005793,GO:0005829,GO:0006470,GO:0006661,GO:0006897,GO:0016020,GO:0032587,GO:0035335,GO:0046856,GO:0048471,GO:0052629,GO:0106018" "phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein binding|nuclear envelope|cytoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cytosol|protein dephosphorylation|phosphatidylinositol biosynthetic process|endocytosis|membrane|ruffle membrane|peptidyl-tyrosine dephosphorylation|phosphatidylinositol dephosphorylation|perinuclear region of cytoplasm|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3,5-bisphosphate phosphatase activity" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system MTMR7 8.526486296 9.363724944 7.689247648 0.821174019 -0.284240111 0.913967262 1 0.068842098 0.055585367 9108 myotubularin related protein 7 "GO:0004438,GO:0004725,GO:0005515,GO:0005737,GO:0005829,GO:0006470,GO:0006661,GO:0012505,GO:0016020,GO:0035335,GO:0046855,GO:0046856" phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity|protein binding|cytoplasm|cytosol|protein dephosphorylation|phosphatidylinositol biosynthetic process|endomembrane system|membrane|peptidyl-tyrosine dephosphorylation|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system MTMR8 65.1353081 57.22276355 73.04785266 1.276552339 0.35225269 0.530386746 1 1.148072827 1.441050639 55613 myotubularin related protein 8 "GO:0004438,GO:0004725,GO:0005515,GO:0005635,GO:0005737,GO:0005829,GO:0006661,GO:0010507,GO:0016020,GO:0016241,GO:0035335,GO:0046856,GO:0052629,GO:0106018" "phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity|protein binding|nuclear envelope|cytoplasm|cytosol|phosphatidylinositol biosynthetic process|negative regulation of autophagy|membrane|regulation of macroautophagy|peptidyl-tyrosine dephosphorylation|phosphatidylinositol dephosphorylation|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3,5-bisphosphate phosphatase activity" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system MTMR9 403.430179 434.8930029 371.967355 0.855307748 -0.225484486 0.436982675 1 3.037884852 2.554846977 66036 myotubularin related protein 9 "GO:0004438,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0006661,GO:0006897,GO:0010507,GO:0010922,GO:0016020,GO:0019903,GO:0030234,GO:0032587,GO:0032991,GO:0046856,GO:0048471,GO:0050821,GO:0060304" phosphatidylinositol-3-phosphatase activity|protein binding|cytoplasm|endoplasmic reticulum|cytosol|phosphatidylinositol biosynthetic process|endocytosis|negative regulation of autophagy|positive regulation of phosphatase activity|membrane|protein phosphatase binding|enzyme regulator activity|ruffle membrane|protein-containing complex|phosphatidylinositol dephosphorylation|perinuclear region of cytoplasm|protein stabilization|regulation of phosphatidylinositol dephosphorylation MTNR1A 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.057271127 4543 melatonin receptor 1A "GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0007186,GO:0007187,GO:0007193,GO:0007617,GO:0007623,GO:0008502,GO:0042562,GO:0043235,GO:0097159" "G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|mating behavior|circadian rhythm|melatonin receptor activity|hormone binding|receptor complex|organic cyclic compound binding" "hsa04080,hsa04713" Neuroactive ligand-receptor interaction|Circadian entrainment MTO1 385.9066892 391.1956199 380.6177586 0.972960174 -0.039547342 0.901295343 1 1.916587831 1.833559337 25821 mitochondrial tRNA translation optimization 1 "GO:0002098,GO:0003723,GO:0005739,GO:0030488,GO:0050660,GO:0070899" tRNA wobble uridine modification|RNA binding|mitochondrion|tRNA methylation|flavin adenine dinucleotide binding|mitochondrial tRNA wobble uridine modification MTOR 1826.586578 1814.481811 1838.691344 1.013342395 0.019121724 0.938141391 1 10.57734128 10.53910929 2475 mechanistic target of rapamycin kinase "GO:0000139,GO:0001002,GO:0001003,GO:0001006,GO:0001156,GO:0001558,GO:0001933,GO:0001938,GO:0002296,GO:0003007,GO:0003179,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005741,GO:0005764,GO:0005765,GO:0005789,GO:0005829,GO:0005979,GO:0006112,GO:0006207,GO:0006468,GO:0007040,GO:0007050,GO:0007281,GO:0007420,GO:0007569,GO:0007584,GO:0007616,GO:0008361,GO:0008542,GO:0009267,GO:0009791,GO:0010507,GO:0010592,GO:0010628,GO:0010718,GO:0010831,GO:0010976,GO:0012505,GO:0014042,GO:0014736,GO:0014823,GO:0016020,GO:0016241,GO:0016242,GO:0016301,GO:0016310,GO:0016605,GO:0018105,GO:0018107,GO:0019901,GO:0019904,GO:0021510,GO:0030163,GO:0030425,GO:0030838,GO:0031397,GO:0031529,GO:0031641,GO:0031667,GO:0031669,GO:0031929,GO:0031931,GO:0031932,GO:0031998,GO:0032095,GO:0032148,GO:0032516,GO:0032868,GO:0032956,GO:0034198,GO:0035176,GO:0035264,GO:0038202,GO:0042060,GO:0042220,GO:0042752,GO:0042802,GO:0043022,GO:0043025,GO:0043087,GO:0043200,GO:0043276,GO:0043278,GO:0043610,GO:0045182,GO:0045335,GO:0045429,GO:0045670,GO:0045727,GO:0045792,GO:0045945,GO:0046777,GO:0046889,GO:0048255,GO:0048511,GO:0048661,GO:0048714,GO:0050731,GO:0050882,GO:0051219,GO:0051496,GO:0051549,GO:0051647,GO:0051897,GO:0055013,GO:0060048,GO:0060135,GO:0060252,GO:0060999,GO:0061051,GO:0070885,GO:0071230,GO:0071233,GO:0071456,GO:0090335,GO:0090559,GO:0098978,GO:0099524,GO:0099547,GO:0106310,GO:0106311,GO:1900034,GO:1901216,GO:1901838,GO:1903691,GO:1904000,GO:1904056,GO:1904058,GO:1904059,GO:1904193,GO:1904197,GO:1904206,GO:1904213,GO:1904690,GO:1990253" "Golgi membrane|RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 3 promoter sequence-specific DNA binding|TFIIIC-class transcription factor complex binding|regulation of cell growth|negative regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|T-helper 1 cell lineage commitment|heart morphogenesis|heart valve morphogenesis|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|mitochondrial outer membrane|lysosome|lysosomal membrane|endoplasmic reticulum membrane|cytosol|regulation of glycogen biosynthetic process|energy reserve metabolic process|'de novo' pyrimidine nucleobase biosynthetic process|protein phosphorylation|lysosome organization|cell cycle arrest|germ cell development|brain development|cell aging|response to nutrient|long-term memory|regulation of cell size|visual learning|cellular response to starvation|post-embryonic development|negative regulation of autophagy|positive regulation of lamellipodium assembly|positive regulation of gene expression|positive regulation of epithelial to mesenchymal transition|positive regulation of myotube differentiation|positive regulation of neuron projection development|endomembrane system|positive regulation of neuron maturation|negative regulation of muscle atrophy|response to activity|membrane|regulation of macroautophagy|negative regulation of macroautophagy|kinase activity|phosphorylation|PML body|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein kinase binding|protein domain specific binding|spinal cord development|protein catabolic process|dendrite|positive regulation of actin filament polymerization|negative regulation of protein ubiquitination|ruffle organization|regulation of myelination|response to nutrient levels|cellular response to nutrient levels|TOR signaling|TORC1 complex|TORC2 complex|regulation of fatty acid beta-oxidation|regulation of response to food|activation of protein kinase B activity|positive regulation of phosphoprotein phosphatase activity|response to insulin|regulation of actin cytoskeleton organization|cellular response to amino acid starvation|social behavior|multicellular organism growth|TORC1 signaling|wound healing|response to cocaine|regulation of circadian rhythm|identical protein binding|ribosome binding|neuronal cell body|regulation of GTPase activity|response to amino acid|anoikis|response to morphine|regulation of carbohydrate utilization|translation regulator activity|phagocytic vesicle|positive regulation of nitric oxide biosynthetic process|regulation of osteoclast differentiation|positive regulation of translation|negative regulation of cell size|positive regulation of transcription by RNA polymerase III|protein autophosphorylation|positive regulation of lipid biosynthetic process|mRNA stabilization|rhythmic process|positive regulation of smooth muscle cell proliferation|positive regulation of oligodendrocyte differentiation|positive regulation of peptidyl-tyrosine phosphorylation|voluntary musculoskeletal movement|phosphoprotein binding|positive regulation of stress fiber assembly|positive regulation of keratinocyte migration|nucleus localization|positive regulation of protein kinase B signaling|cardiac muscle cell development|cardiac muscle contraction|maternal process involved in female pregnancy|positive regulation of glial cell proliferation|positive regulation of dendritic spine development|positive regulation of cell growth involved in cardiac muscle cell development|negative regulation of calcineurin-NFAT signaling cascade|cellular response to amino acid stimulus|cellular response to leucine|cellular response to hypoxia|regulation of brown fat cell differentiation|regulation of membrane permeability|glutamatergic synapse|postsynaptic cytosol|regulation of translation at synapse, modulating synaptic transmission|protein serine kinase activity|protein threonine kinase activity|regulation of cellular response to heat|positive regulation of neuron death|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|positive regulation of wound healing, spreading of epidermal cells|positive regulation of eating behavior|positive regulation of cholangiocyte proliferation|positive regulation of sensory perception of pain|regulation of locomotor rhythm|negative regulation of cholangiocyte apoptotic process|positive regulation of granulosa cell proliferation|positive regulation of skeletal muscle hypertrophy|negative regulation of iodide transmembrane transport|positive regulation of cytoplasmic translational initiation|cellular response to leucine starvation" "hsa01521,hsa01522,hsa04012,hsa04066,hsa04072,hsa04136,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04218,hsa04371,hsa04630,hsa04659,hsa04714,hsa04910,hsa04919,hsa04920,hsa04930,hsa04931,hsa04935,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022,hsa05131,hsa05163,hsa05165,hsa05167,hsa05168,hsa05170,hsa05200,hsa05205,hsa05206,hsa05210,hsa05212,hsa05214,hsa05215,hsa05221,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|HIF-1 signaling pathway|Phospholipase D signaling pathway|Autophagy - other|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Apelin signaling pathway|JAK-STAT signaling pathway|Th17 cell differentiation|Thermogenesis|Insulin signaling pathway|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Type II diabetes mellitus|Insulin resistance|Growth hormone synthesis, secretion and action|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis|Human cytomegalovirus infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Pancreatic cancer|Glioma|Prostate cancer|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" MTPAP 368.4523966 374.5489978 362.3557954 0.967445642 -0.047747493 0.880842604 1 3.595142377 3.41990345 55149 mitochondrial poly(A) polymerase "GO:0000287,GO:0002134,GO:0003723,GO:0004652,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0006378,GO:0006397,GO:0016779,GO:0030145,GO:0042802,GO:0042803,GO:0043231,GO:0071044" magnesium ion binding|UTP binding|RNA binding|polynucleotide adenylyltransferase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|mitochondrion|mRNA polyadenylation|mRNA processing|nucleotidyltransferase activity|manganese ion binding|identical protein binding|protein homodimerization activity|intracellular membrane-bounded organelle|histone mRNA catabolic process MTR 1741.286502 1808.239328 1674.333675 0.925946942 -0.110998568 0.641259245 1 8.367502778 7.6182136 4548 5-methyltetrahydrofolate-homocysteine methyltransferase "GO:0000096,GO:0005515,GO:0005829,GO:0007399,GO:0008270,GO:0008705,GO:0009086,GO:0009235,GO:0031103,GO:0031419,GO:0032259,GO:0042558,GO:0048678,GO:0071732" sulfur amino acid metabolic process|protein binding|cytosol|nervous system development|zinc ion binding|methionine synthase activity|methionine biosynthetic process|cobalamin metabolic process|axon regeneration|cobalamin binding|methylation|pteridine-containing compound metabolic process|response to axon injury|cellular response to nitric oxide "hsa00270,hsa00450,hsa00670" Cysteine and methionine metabolism|Selenocompound metabolism|One carbon pool by folate MTRES1 106.3209752 116.5263549 96.1155956 0.824839975 -0.277813842 0.553561874 1 3.87464012 3.142478029 51250 mitochondrial transcription rescue factor 1 "GO:0003723,GO:0005515,GO:0005739,GO:0005759,GO:1903108" RNA binding|protein binding|mitochondrion|mitochondrial matrix|regulation of mitochondrial transcription MTREX 2177.02546 2069.383213 2284.667707 1.10403317 0.142783517 0.546622709 1 27.88164067 30.26715675 23517 Mtr4 exosome RNA helicase "GO:0000176,GO:0000178,GO:0000398,GO:0000460,GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0006401,GO:0016076,GO:0016607,GO:0031499,GO:0071013" "nuclear exosome (RNase complex)|exosome (RNase complex)|mRNA splicing, via spliceosome|maturation of 5.8S rRNA|RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|rRNA processing|RNA catabolic process|snRNA catabolic process|nuclear speck|TRAMP complex|catalytic step 2 spliceosome" hsa03018 RNA degradation MTRF1 287.5919934 282.9925761 292.1914106 1.032505568 0.046149562 0.896377254 1 2.351361306 2.387167803 9617 mitochondrial translation release factor 1 "GO:0003747,GO:0005739,GO:0006449,GO:0070126" translation release factor activity|mitochondrion|regulation of translational termination|mitochondrial translational termination MTRF1L 412.8486241 417.2059669 408.4912813 0.97911179 -0.030454505 0.924264145 1 5.626867744 5.417141333 54516 mitochondrial translation release factor 1 like "GO:0003747,GO:0005739,GO:0005759,GO:0070126" translation release factor activity|mitochondrion|mitochondrial matrix|mitochondrial translational termination MTRFR 587.689075 541.015219 634.362931 1.172541749 0.229639291 0.385938889 1 10.17012606 11.72535039 91574 mitochondrial translation release factor in rescue MTRNR2L2 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.165089128 0.249934452 100462981 MT-RNR2 like 2 "GO:0005576,GO:0005737,GO:0048019,GO:1900118,GO:2000272" extracellular region|cytoplasm|receptor antagonist activity|negative regulation of execution phase of apoptosis|negative regulation of signaling receptor activity MTRR 827.084262 870.8264198 783.3421041 0.899538744 -0.152742673 0.544316087 1 12.12797639 10.72702752 4552 5-methyltetrahydrofolate-homocysteine methyltransferase reductase "GO:0000096,GO:0003958,GO:0005515,GO:0005654,GO:0005829,GO:0006306,GO:0006555,GO:0009086,GO:0009235,GO:0010181,GO:0016491,GO:0016709,GO:0016723,GO:0030586,GO:0032259,GO:0033353,GO:0043418,GO:0045111,GO:0046655,GO:0050444,GO:0050660,GO:0050661,GO:0050667,GO:0055114,GO:0070402,GO:0071949,GO:1904042" "sulfur amino acid metabolic process|NADPH-hemoprotein reductase activity|protein binding|nucleoplasm|cytosol|DNA methylation|methionine metabolic process|methionine biosynthetic process|cobalamin metabolic process|FMN binding|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor|[methionine synthase] reductase activity|methylation|S-adenosylmethionine cycle|homocysteine catabolic process|intermediate filament cytoskeleton|folic acid metabolic process|aquacobalamin reductase (NADPH) activity|flavin adenine dinucleotide binding|NADP binding|homocysteine metabolic process|oxidation-reduction process|NADPH binding|FAD binding|negative regulation of cystathionine beta-synthase activity" MTSS1 4771.107702 4250.090711 5292.124694 1.245179234 0.316353422 0.186825447 1 34.37180329 42.08287144 9788 MTSS I-BAR domain containing 1 "GO:0001726,GO:0003785,GO:0005102,GO:0005515,GO:0005737,GO:0007009,GO:0007155,GO:0007169,GO:0015629,GO:0030035,GO:0030036,GO:0030139,GO:0042802,GO:0050680,GO:0061333,GO:0071498,GO:0072102,GO:0072160,GO:2001013" ruffle|actin monomer binding|signaling receptor binding|protein binding|cytoplasm|plasma membrane organization|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|actin cytoskeleton|microspike assembly|actin cytoskeleton organization|endocytic vesicle|identical protein binding|negative regulation of epithelial cell proliferation|renal tubule morphogenesis|cellular response to fluid shear stress|glomerulus morphogenesis|nephron tubule epithelial cell differentiation|epithelial cell proliferation involved in renal tubule morphogenesis MTSS2 869.1467967 940.5341499 797.7594435 0.848198275 -0.237526546 0.341222281 1 9.073495834 7.567339309 92154 MTSS I-BAR domain containing 2 "GO:0003785,GO:0005096,GO:0005515,GO:0005546,GO:0007009,GO:0030027,GO:0030864,GO:0031267,GO:0032587,GO:0036120,GO:0090630,GO:0097178,GO:0097581" "actin monomer binding|GTPase activator activity|protein binding|phosphatidylinositol-4,5-bisphosphate binding|plasma membrane organization|lamellipodium|cortical actin cytoskeleton|small GTPase binding|ruffle membrane|cellular response to platelet-derived growth factor stimulus|activation of GTPase activity|ruffle assembly|lamellipodium organization" MTTP 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.041200824 0 4547 microsomal triglyceride transfer protein "GO:0005319,GO:0005515,GO:0005548,GO:0005783,GO:0005788,GO:0005791,GO:0005794,GO:0006497,GO:0006629,GO:0006641,GO:0007623,GO:0008289,GO:0009306,GO:0015914,GO:0015918,GO:0016323,GO:0031526,GO:0031528,GO:0031982,GO:0034185,GO:0034197,GO:0034374,GO:0034377,GO:0034378,GO:0034379,GO:0042157,GO:0042632,GO:0042953,GO:0043235,GO:0044877,GO:0046982,GO:0051592,GO:0120009,GO:0120014,GO:0120019,GO:0120020,GO:0140344,GO:1902388,GO:1902389,GO:1904121" lipid transporter activity|protein binding|phospholipid transporter activity|endoplasmic reticulum|endoplasmic reticulum lumen|rough endoplasmic reticulum|Golgi apparatus|protein lipidation|lipid metabolic process|triglyceride metabolic process|circadian rhythm|lipid binding|protein secretion|phospholipid transport|sterol transport|basolateral plasma membrane|brush border membrane|microvillus membrane|vesicle|apolipoprotein binding|triglyceride transport|low-density lipoprotein particle remodeling|plasma lipoprotein particle assembly|chylomicron assembly|very-low-density lipoprotein particle assembly|lipoprotein metabolic process|cholesterol homeostasis|lipoprotein transport|receptor complex|protein-containing complex binding|protein heterodimerization activity|response to calcium ion|intermembrane lipid transfer|phospholipid transfer activity|phosphatidylcholine transfer activity|cholesterol transfer activity|triglyceride transfer activity|ceramide 1-phosphate transfer activity|ceramide 1-phosphate transport|phosphatidylethanolamine transfer activity hsa04975 Fat digestion and absorption MTURN 477.9789018 486.9136971 469.0441065 0.963300292 -0.053942492 0.852299505 1 5.942302562 5.628434693 222166 "maturin, neural progenitor differentiation regulator homolog" "GO:0005515,GO:0005737,GO:0007275,GO:0032088,GO:0045654,GO:0046330,GO:0070374" protein binding|cytoplasm|multicellular organism development|negative regulation of NF-kappaB transcription factor activity|positive regulation of megakaryocyte differentiation|positive regulation of JNK cascade|positive regulation of ERK1 and ERK2 cascade MTUS1 17.21148845 22.88910542 11.53387147 0.503902239 -0.988784228 0.282662815 1 0.101272549 0.050177522 57509 microtubule associated scaffold protein 1 "GO:0005615,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005794,GO:0005815,GO:0005819,GO:0005874,GO:0005886,GO:0008017,GO:0010758,GO:0015630" extracellular space|nucleus|nucleolus|cytoplasm|mitochondrion|Golgi apparatus|microtubule organizing center|spindle|microtubule|plasma membrane|microtubule binding|regulation of macrophage chemotaxis|microtubule cytoskeleton MTX1 413.7305221 415.1251392 412.3359051 0.99328098 -0.009726209 0.9824381 1 13.41069353 13.09768483 4580 metaxin 1 "GO:0001401,GO:0003674,GO:0005515,GO:0005737,GO:0007005,GO:0007007,GO:0007595,GO:0015031,GO:0016021,GO:0140275" SAM complex|molecular_function|protein binding|cytoplasm|mitochondrion organization|inner mitochondrial membrane organization|lactation|protein transport|integral component of membrane|MIB complex MTX2 1038.16179 911.4025612 1164.921019 1.278162986 0.354071814 0.148483836 1 28.79803411 36.19263949 10651 metaxin 2 "GO:0001401,GO:0005515,GO:0005730,GO:0005737,GO:0005739,GO:0005741,GO:0006839,GO:0007005,GO:0007007,GO:0015031,GO:0140275" SAM complex|protein binding|nucleolus|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial transport|mitochondrion organization|inner mitochondrial membrane organization|protein transport|MIB complex MTX3 707.2328758 739.7342706 674.7314811 0.912126838 -0.132693639 0.606946998 1 4.979598694 4.466020963 345778 metaxin 3 "GO:0001401,GO:0003674,GO:0005737,GO:0007005,GO:0007007,GO:0015031,GO:0140275" SAM complex|molecular_function|cytoplasm|mitochondrion organization|inner mitochondrial membrane organization|protein transport|MIB complex MUC1 15.41309384 13.52538047 17.30080721 1.279136453 0.355170173 0.762138602 1 0.177352505 0.223061893 4582 "mucin 1, cell surface associated" "GO:0000785,GO:0000978,GO:0002039,GO:0002223,GO:0003712,GO:0005515,GO:0005615,GO:0005634,GO:0005796,GO:0005886,GO:0005887,GO:0006977,GO:0006978,GO:0010944,GO:0016266,GO:0016324,GO:0019221,GO:0031982,GO:0033629,GO:0036003,GO:0043618,GO:0070062,GO:0090240,GO:1902166" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|p53 binding|stimulatory C-type lectin receptor signaling pathway|transcription coregulator activity|protein binding|extracellular space|nucleus|Golgi lumen|plasma membrane|integral component of plasma membrane|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of transcription by competitive promoter binding|O-glycan processing|apical plasma membrane|cytokine-mediated signaling pathway|vesicle|negative regulation of cell adhesion mediated by integrin|positive regulation of transcription from RNA polymerase II promoter in response to stress|regulation of transcription from RNA polymerase II promoter in response to stress|extracellular exosome|positive regulation of histone H4 acetylation|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" MUC12 5.444873611 4.161655531 6.728091692 1.616686351 0.693039812 0.747994079 1 0.013570812 0.021572614 10071 "mucin 12, cell surface associated" "GO:0001558,GO:0002223,GO:0003674,GO:0005796,GO:0005886,GO:0005887,GO:0016266" regulation of cell growth|stimulatory C-type lectin receptor signaling pathway|molecular_function|Golgi lumen|plasma membrane|integral component of plasma membrane|O-glycan processing MUC20 5.682647391 10.40413883 0.961155956 0.092382077 -3.436243205 0.058049477 1 0.222723533 0.020231357 200958 "mucin 20, cell surface associated" "GO:0000187,GO:0002223,GO:0005576,GO:0005796,GO:0005886,GO:0009925,GO:0016266,GO:0016324,GO:0031528,GO:0042802,GO:0048012" activation of MAPK activity|stimulatory C-type lectin receptor signaling pathway|extracellular region|Golgi lumen|plasma membrane|basal plasma membrane|O-glycan processing|apical plasma membrane|microvillus membrane|identical protein binding|hepatocyte growth factor receptor signaling pathway MUC3A 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.019745724 0.008968132 4584 "mucin 3A, cell surface associated" "GO:0002223,GO:0005201,GO:0005576,GO:0005796,GO:0005886,GO:0016021,GO:0016266,GO:0030197" "stimulatory C-type lectin receptor signaling pathway|extracellular matrix structural constituent|extracellular region|Golgi lumen|plasma membrane|integral component of membrane|O-glycan processing|extracellular matrix constituent, lubricant activity" MUCL3 5.682647391 10.40413883 0.961155956 0.092382077 -3.436243205 0.058049477 1 0.104507767 0.009493087 135656 mucin like 3 "GO:0003674,GO:0005575,GO:0005737,GO:0005886,GO:0008150,GO:0016021" molecular_function|cellular_component|cytoplasm|plasma membrane|biological_process|integral component of membrane MUL1 432.3139331 511.8836303 352.7442358 0.68911021 -0.537193362 0.05771367 1 8.697322045 5.893121763 79594 mitochondrial E3 ubiquitin protein ligase 1 "GO:0000209,GO:0000266,GO:0002039,GO:0004842,GO:0005515,GO:0005739,GO:0005777,GO:0006915,GO:0006919,GO:0007257,GO:0010637,GO:0010821,GO:0016020,GO:0016567,GO:0016925,GO:0019789,GO:0030308,GO:0030424,GO:0031307,GO:0031625,GO:0031648,GO:0033235,GO:0042802,GO:0043025,GO:0043123,GO:0045824,GO:0046872,GO:0050689,GO:0050821,GO:0051646,GO:0051881,GO:0051898,GO:0060339,GO:0061630,GO:0071360,GO:0071650,GO:0090141,GO:1901028,GO:1903861,GO:1904925" protein polyubiquitination|mitochondrial fission|p53 binding|ubiquitin-protein transferase activity|protein binding|mitochondrion|peroxisome|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|activation of JUN kinase activity|negative regulation of mitochondrial fusion|regulation of mitochondrion organization|membrane|protein ubiquitination|protein sumoylation|SUMO transferase activity|negative regulation of cell growth|axon|integral component of mitochondrial outer membrane|ubiquitin protein ligase binding|protein destabilization|positive regulation of protein sumoylation|identical protein binding|neuronal cell body|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of innate immune response|metal ion binding|negative regulation of defense response to virus by host|protein stabilization|mitochondrion localization|regulation of mitochondrial membrane potential|negative regulation of protein kinase B signaling|negative regulation of type I interferon-mediated signaling pathway|ubiquitin protein ligase activity|cellular response to exogenous dsRNA|negative regulation of chemokine (C-C motif) ligand 5 production|positive regulation of mitochondrial fission|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of dendrite extension|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization MUS81 609.7157896 639.8545378 579.5770415 0.905795001 -0.142743518 0.589345321 1 13.90385207 12.38329549 80198 MUS81 structure-specific endonuclease subunit "GO:0000712,GO:0000727,GO:0000737,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006281,GO:0031573,GO:0033687,GO:0036297,GO:0046872,GO:0048257,GO:0048476,GO:0072429" "resolution of meiotic recombination intermediates|double-strand break repair via break-induced replication|DNA catabolic process, endonucleolytic|DNA binding|protein binding|nucleus|nucleoplasm|nucleolus|DNA repair|intra-S DNA damage checkpoint|osteoblast proliferation|interstrand cross-link repair|metal ion binding|3'-flap endonuclease activity|Holliday junction resolvase complex|response to intra-S DNA damage checkpoint signaling" "hsa03440,hsa03460" Homologous recombination|Fanconi anemia pathway MUSK 3.522561699 4.161655531 2.883467868 0.692865579 -0.529352609 0.940314863 1 0.02458217 0.01674713 4593 muscle associated receptor tyrosine kinase "GO:0001934,GO:0004713,GO:0004714,GO:0005515,GO:0005518,GO:0005524,GO:0005887,GO:0007169,GO:0007275,GO:0007528,GO:0007613,GO:0008582,GO:0010628,GO:0018108,GO:0030154,GO:0031594,GO:0033674,GO:0038062,GO:0038063,GO:0043235,GO:0045211,GO:0046777,GO:0046872,GO:0071340,GO:2000541" positive regulation of protein phosphorylation|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|protein binding|collagen binding|ATP binding|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|neuromuscular junction development|memory|regulation of synaptic growth at neuromuscular junction|positive regulation of gene expression|peptidyl-tyrosine phosphorylation|cell differentiation|neuromuscular junction|positive regulation of kinase activity|protein tyrosine kinase collagen receptor activity|collagen-activated tyrosine kinase receptor signaling pathway|receptor complex|postsynaptic membrane|protein autophosphorylation|metal ion binding|skeletal muscle acetylcholine-gated channel clustering|positive regulation of protein geranylgeranylation MUTYH 417.6393126 454.6608667 380.6177586 0.837146512 -0.256447959 0.371291046 1 9.060647806 7.458163501 4595 mutY DNA glycosylase "GO:0000701,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006281,GO:0006284,GO:0006298,GO:0019104,GO:0032357,GO:0032405,GO:0032406,GO:0032407,GO:0032408,GO:0034039,GO:0035485,GO:0045007,GO:0046872,GO:0051539" "purine-specific mismatch base pair DNA N-glycosylase activity|protein binding|nucleus|nucleoplasm|mitochondrion|DNA repair|base-excision repair|mismatch repair|DNA N-glycosylase activity|oxidized purine DNA binding|MutLalpha complex binding|MutLbeta complex binding|MutSalpha complex binding|MutSbeta complex binding|8-oxo-7,8-dihydroguanine DNA N-glycosylase activity|adenine/guanine mispair binding|depurination|metal ion binding|4 iron, 4 sulfur cluster binding" hsa03410 Base excision repair MVB12A 552.3244494 546.2172884 558.4316104 1.022361654 0.031905631 0.912016083 1 19.42079465 19.52282794 93343 multivesicular body subunit 12A "GO:0000813,GO:0005515,GO:0005654,GO:0005794,GO:0005813,GO:0005829,GO:0008289,GO:0010008,GO:0015031,GO:0016197,GO:0016236,GO:0017124,GO:0019058,GO:0019075,GO:0031902,GO:0031982,GO:0032510,GO:0032801,GO:0036258,GO:0039702,GO:0042058,GO:0043130,GO:0043162,GO:0043657,GO:0046755,GO:0070062,GO:0075733" ESCRT I complex|protein binding|nucleoplasm|Golgi apparatus|centrosome|cytosol|lipid binding|endosome membrane|protein transport|endosomal transport|macroautophagy|SH3 domain binding|viral life cycle|virus maturation|late endosome membrane|vesicle|endosome to lysosome transport via multivesicular body sorting pathway|receptor catabolic process|multivesicular body assembly|viral budding via host ESCRT complex|regulation of epidermal growth factor receptor signaling pathway|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|host cell|viral budding|extracellular exosome|intracellular transport of virus hsa04144 Endocytosis MVB12B 234.8774852 211.2040182 258.5509522 1.224176294 0.291811335 0.397407908 1 1.407538745 1.694242228 89853 multivesicular body subunit 12B "GO:0000813,GO:0005515,GO:0005634,GO:0005769,GO:0005770,GO:0005829,GO:0005886,GO:0008289,GO:0010008,GO:0015031,GO:0016197,GO:0019058,GO:0019075,GO:0031902,GO:0031982,GO:0042058,GO:0043130,GO:0043162,GO:0043657,GO:0046755,GO:0070062,GO:0075733" ESCRT I complex|protein binding|nucleus|early endosome|late endosome|cytosol|plasma membrane|lipid binding|endosome membrane|protein transport|endosomal transport|viral life cycle|virus maturation|late endosome membrane|vesicle|regulation of epidermal growth factor receptor signaling pathway|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|host cell|viral budding|extracellular exosome|intracellular transport of virus hsa04144 Endocytosis MVD 951.1325165 922.8471139 979.4179192 1.0613003 0.085832932 0.731345833 1 23.51989224 24.54396898 4597 mevalonate diphosphate decarboxylase "GO:0004163,GO:0005524,GO:0005777,GO:0005829,GO:0006489,GO:0006695,GO:0008284,GO:0008299,GO:0019287,GO:0030544,GO:0042803,GO:0045540" "diphosphomevalonate decarboxylase activity|ATP binding|peroxisome|cytosol|dolichyl diphosphate biosynthetic process|cholesterol biosynthetic process|positive regulation of cell population proliferation|isoprenoid biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate pathway|Hsp70 protein binding|protein homodimerization activity|regulation of cholesterol biosynthetic process" hsa00900 Terpenoid backbone biosynthesis MVK 225.7961934 187.2744989 264.3178879 1.411392846 0.497119602 0.152723563 1 3.660987476 5.080627253 4598 mevalonate kinase "GO:0000287,GO:0004496,GO:0005515,GO:0005524,GO:0005777,GO:0005829,GO:0006695,GO:0008299,GO:0016310,GO:0019287,GO:0042802,GO:0043231,GO:0045540,GO:0050728" "magnesium ion binding|mevalonate kinase activity|protein binding|ATP binding|peroxisome|cytosol|cholesterol biosynthetic process|isoprenoid biosynthetic process|phosphorylation|isopentenyl diphosphate biosynthetic process, mevalonate pathway|identical protein binding|intracellular membrane-bounded organelle|regulation of cholesterol biosynthetic process|negative regulation of inflammatory response" "hsa00900,hsa04146" Terpenoid backbone biosynthesis|Peroxisome MVP 4842.938462 4785.90386 4899.973064 1.023834412 0.033982402 0.888073825 1 87.32133091 87.90655231 9961 major vault protein "GO:0005515,GO:0005576,GO:0005634,GO:0005643,GO:0005737,GO:0005829,GO:0005856,GO:0015031,GO:0016020,GO:0019901,GO:0019903,GO:0031953,GO:0034774,GO:0038127,GO:0042059,GO:0042802,GO:0043312,GO:0048471,GO:0051028,GO:0061099,GO:0070062,GO:1904813" protein binding|extracellular region|nucleus|nuclear pore|cytoplasm|cytosol|cytoskeleton|protein transport|membrane|protein kinase binding|protein phosphatase binding|negative regulation of protein autophosphorylation|secretory granule lumen|ERBB signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|identical protein binding|neutrophil degranulation|perinuclear region of cytoplasm|mRNA transport|negative regulation of protein tyrosine kinase activity|extracellular exosome|ficolin-1-rich granule lumen MX1 61.29068428 57.22276355 65.35860501 1.142178409 0.191788018 0.753634566 1 0.523013139 0.587378065 4599 MX dynamin like GTPase 1 "GO:0000266,GO:0003374,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005789,GO:0005829,GO:0005886,GO:0006915,GO:0006952,GO:0007165,GO:0008017,GO:0009615,GO:0014069,GO:0015630,GO:0016020,GO:0016185,GO:0030424,GO:0031410,GO:0031623,GO:0031965,GO:0031966,GO:0034340,GO:0042802,GO:0044327,GO:0045071,GO:0045087,GO:0048285,GO:0048471,GO:0050803,GO:0051607,GO:0060337,GO:0061025,GO:0098793,GO:0098844,GO:0098884" mitochondrial fission|dynamin family protein polymerization involved in mitochondrial fission|GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|apoptotic process|defense response|signal transduction|microtubule binding|response to virus|postsynaptic density|microtubule cytoskeleton|membrane|synaptic vesicle budding from presynaptic endocytic zone membrane|axon|cytoplasmic vesicle|receptor internalization|nuclear membrane|mitochondrial membrane|response to type I interferon|identical protein binding|dendritic spine head|negative regulation of viral genome replication|innate immune response|organelle fission|perinuclear region of cytoplasm|regulation of synapse structure or activity|defense response to virus|type I interferon signaling pathway|membrane fusion|presynapse|postsynaptic endocytic zone membrane|postsynaptic neurotransmitter receptor internalization "hsa05160,hsa05162,hsa05164,hsa05165,hsa05171" Hepatitis C|Measles|Influenza A|Human papillomavirus infection|Coronavirus disease - COVID-19 MX2 6.886607545 4.161655531 9.61155956 2.309551929 1.207612985 0.417805055 1 0.059084838 0.134176037 4600 MX dynamin like GTPase 2 "GO:0000266,GO:0003374,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005643,GO:0005737,GO:0005829,GO:0005886,GO:0006952,GO:0008017,GO:0009615,GO:0014069,GO:0015630,GO:0016020,GO:0016185,GO:0030424,GO:0031410,GO:0031623,GO:0031966,GO:0035455,GO:0044327,GO:0046822,GO:0048285,GO:0050803,GO:0051028,GO:0051607,GO:0051726,GO:0060337,GO:0061025,GO:0098793,GO:0098844,GO:0098884" mitochondrial fission|dynamin family protein polymerization involved in mitochondrial fission|GTPase activity|protein binding|GTP binding|nucleus|nuclear pore|cytoplasm|cytosol|plasma membrane|defense response|microtubule binding|response to virus|postsynaptic density|microtubule cytoskeleton|membrane|synaptic vesicle budding from presynaptic endocytic zone membrane|axon|cytoplasmic vesicle|receptor internalization|mitochondrial membrane|response to interferon-alpha|dendritic spine head|regulation of nucleocytoplasmic transport|organelle fission|regulation of synapse structure or activity|mRNA transport|defense response to virus|regulation of cell cycle|type I interferon signaling pathway|membrane fusion|presynapse|postsynaptic endocytic zone membrane|postsynaptic neurotransmitter receptor internalization "hsa05160,hsa05162,hsa05164,hsa05165,hsa05171" Hepatitis C|Measles|Influenza A|Human papillomavirus infection|Coronavirus disease - COVID-19 MXD1 165.8975532 153.9812546 177.8138519 1.154775965 0.207612985 0.60365958 1 1.480932881 1.681528724 4084 MAX dimerization protein 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005654,GO:0005739,GO:0005829,GO:0006357,GO:0046983" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|mitochondrion|cytosol|regulation of transcription by RNA polymerase II|protein dimerization activity" MXD3 379.7484943 368.3065145 391.1904741 1.062132921 0.086964324 0.7743831 1 7.111375455 7.426832978 83463 MAX dimerization protein 3 "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046983" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|protein dimerization activity" MXD4 664.8583398 649.2182628 680.4984168 1.04818126 0.067888221 0.797672834 1 8.950551659 9.224808791 10608 MAX dimerization protein 4 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046983" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|protein dimerization activity" MXI1 601.0760613 513.964458 688.1876645 1.338979094 0.421133436 0.109173324 1 7.137480744 9.397015095 4601 "MAX interactor 1, dimerization protein" "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0046983,GO:0090575" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|protein dimerization activity|RNA polymerase II transcription regulator complex" bHLH MXRA7 2959.332296 2849.693625 3068.970967 1.07694769 0.106948177 0.652118705 1 20.00301345 21.1817196 439921 matrix remodeling associated 7 "GO:0005783,GO:0016021,GO:0062023" endoplasmic reticulum|integral component of membrane|collagen-containing extracellular matrix MXRA8 19.05454243 20.80827765 17.30080721 0.831438695 -0.266318203 0.810552514 1 0.385858073 0.315448889 54587 matrix remodeling associated 8 "GO:0003674,GO:0005515,GO:0005634,GO:0005788,GO:0005923,GO:0007155,GO:0009986,GO:0016021,GO:0016032,GO:0043687,GO:0044267,GO:0060170,GO:0060857,GO:0070062" molecular_function|protein binding|nucleus|endoplasmic reticulum lumen|bicellular tight junction|cell adhesion|cell surface|integral component of membrane|viral process|post-translational protein modification|cellular protein metabolic process|ciliary membrane|establishment of glial blood-brain barrier|extracellular exosome MYADM 2152.793386 2076.66611 2228.920662 1.073316818 0.102075989 0.667081608 1 29.0125271 30.61855369 91663 myeloid associated differentiation marker "GO:0001726,GO:0001933,GO:0003674,GO:0005515,GO:0005886,GO:0005911,GO:0010629,GO:0010810,GO:0016021,GO:0030335,GO:0030837,GO:0030864,GO:0031579,GO:0034115,GO:0045121,GO:0045217,GO:0061028,GO:0072659,GO:0090038,GO:1900026" ruffle|negative regulation of protein phosphorylation|molecular_function|protein binding|plasma membrane|cell-cell junction|negative regulation of gene expression|regulation of cell-substrate adhesion|integral component of membrane|positive regulation of cell migration|negative regulation of actin filament polymerization|cortical actin cytoskeleton|membrane raft organization|negative regulation of heterotypic cell-cell adhesion|membrane raft|cell-cell junction maintenance|establishment of endothelial barrier|protein localization to plasma membrane|negative regulation of protein kinase C signaling|positive regulation of substrate adhesion-dependent cell spreading MYB 29.34482478 26.01034707 32.6793025 1.25639625 0.329291542 0.684329638 1 0.37772093 0.466625921 4602 "MYB proto-oncogene, transcription factor" "GO:0000122,GO:0000278,GO:0000978,GO:0000981,GO:0001228,GO:0001666,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006338,GO:0006355,GO:0016363,GO:0032967,GO:0043525,GO:0045624,GO:0045892,GO:0045893,GO:0045944,GO:0048661,GO:0051571,GO:0051574,GO:0060252,GO:0070301,GO:0071300,GO:0071636,GO:1902036,GO:1904899,GO:2000491,GO:2000845" "negative regulation of transcription by RNA polymerase II|mitotic cell cycle|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|response to hypoxia|protein binding|nucleus|nucleoplasm|cytosol|chromatin remodeling|regulation of transcription, DNA-templated|nuclear matrix|positive regulation of collagen biosynthetic process|positive regulation of neuron apoptotic process|positive regulation of T-helper cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of smooth muscle cell proliferation|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of glial cell proliferation|cellular response to hydrogen peroxide|cellular response to retinoic acid|positive regulation of transforming growth factor beta production|regulation of hematopoietic stem cell differentiation|positive regulation of hepatic stellate cell proliferation|positive regulation of hepatic stellate cell activation|positive regulation of testosterone secretion" hsa04151 PI3K-Akt signaling pathway MYB MYBBP1A 958.2556691 1135.091546 781.4197922 0.688420062 -0.538638954 0.029108755 0.88444427 13.35488307 9.039924147 10514 MYB binding protein 1a "GO:0001649,GO:0003714,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006355,GO:0008134,GO:0016020,GO:0022904,GO:0032922,GO:0042149,GO:0042254,GO:0042564,GO:0043231,GO:0043565,GO:0045815,GO:0045892,GO:0070888,GO:0071158,GO:0072332,GO:2000210" "osteoblast differentiation|transcription corepressor activity|RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|regulation of transcription, DNA-templated|transcription factor binding|membrane|respiratory electron transport chain|circadian regulation of gene expression|cellular response to glucose starvation|ribosome biogenesis|NLS-dependent protein nuclear import complex|intracellular membrane-bounded organelle|sequence-specific DNA binding|positive regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|E-box binding|positive regulation of cell cycle arrest|intrinsic apoptotic signaling pathway by p53 class mediator|positive regulation of anoikis" MYBL1 679.1033008 480.6712138 877.5353878 1.825645811 0.868406899 0.000788633 0.171180146 4.479228085 8.040644869 4603 MYB proto-oncogene like 1 "GO:0000278,GO:0000978,GO:0000981,GO:0001228,GO:0005634,GO:0005654,GO:0006355,GO:0007141,GO:0007283,GO:0010529,GO:0030154,GO:0045893,GO:0045944,GO:1990511" "mitotic cell cycle|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription, DNA-templated|male meiosis I|spermatogenesis|negative regulation of transposition|cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|piRNA biosynthetic process" MYB MYBL2 2533.299246 2553.175668 2513.422825 0.98443004 -0.022639412 0.925409593 1 51.07132416 49.43484248 4605 MYB proto-oncogene like 2 "GO:0000278,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0031523,GO:0043525,GO:0045944,GO:0051726,GO:0090307,GO:1990830,GO:1990837" "mitotic cell cycle|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|Myb complex|positive regulation of neuron apoptotic process|positive regulation of transcription by RNA polymerase II|regulation of cell cycle|mitotic spindle assembly|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding" hsa04218 Cellular senescence MYB MYBPC3 14.0902468 16.64662212 11.53387147 0.692865579 -0.529352609 0.63153295 1 0.210671005 0.143524133 4607 myosin binding protein C3 "GO:0001671,GO:0003007,GO:0003779,GO:0005515,GO:0005829,GO:0005863,GO:0006942,GO:0007155,GO:0008307,GO:0014705,GO:0017022,GO:0030017,GO:0030049,GO:0031432,GO:0031672,GO:0032036,GO:0032781,GO:0032971,GO:0042802,GO:0046872,GO:0055010,GO:0060048,GO:0097512" ATPase activator activity|heart morphogenesis|actin binding|protein binding|cytosol|striated muscle myosin thick filament|regulation of striated muscle contraction|cell adhesion|structural constituent of muscle|C zone|myosin binding|sarcomere|muscle filament sliding|titin binding|A band|myosin heavy chain binding|positive regulation of ATPase activity|regulation of muscle filament sliding|identical protein binding|metal ion binding|ventricular cardiac muscle tissue morphogenesis|cardiac muscle contraction|cardiac myofibril "hsa05410,hsa05414" Hypertrophic cardiomyopathy|Dilated cardiomyopathy MYC 1809.102102 1872.744989 1745.459216 0.932032512 -0.101547814 0.669751168 1 22.12150467 20.2729479 4609 "MYC proto-oncogene, bHLH transcription factor" "GO:0000082,GO:0000122,GO:0000165,GO:0000785,GO:0000978,GO:0000981,GO:0001046,GO:0001227,GO:0001228,GO:0001658,GO:0002053,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006112,GO:0006338,GO:0006357,GO:0006879,GO:0006974,GO:0007050,GO:0007219,GO:0008134,GO:0008284,GO:0010332,GO:0010468,GO:0010628,GO:0015671,GO:0016579,GO:0019221,GO:0032204,GO:0032873,GO:0032986,GO:0032991,GO:0033613,GO:0034644,GO:0035690,GO:0042493,GO:0043066,GO:0043280,GO:0044346,GO:0044877,GO:0045656,GO:0045893,GO:0045944,GO:0046983,GO:0048146,GO:0048147,GO:0050679,GO:0051276,GO:0051782,GO:0051973,GO:0070371,GO:0070491,GO:0070848,GO:0070888,GO:0071456,GO:0090096,GO:1904672,GO:1904837,GO:1905643,GO:2000573,GO:2001022" "G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|MAPK cascade|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|core promoter sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal cell proliferation|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|energy reserve metabolic process|chromatin remodeling|regulation of transcription by RNA polymerase II|cellular iron ion homeostasis|cellular response to DNA damage stimulus|cell cycle arrest|Notch signaling pathway|transcription factor binding|positive regulation of cell population proliferation|response to gamma radiation|regulation of gene expression|positive regulation of gene expression|oxygen transport|protein deubiquitination|cytokine-mediated signaling pathway|regulation of telomere maintenance|negative regulation of stress-activated MAPK cascade|protein-DNA complex disassembly|protein-containing complex|activating transcription factor binding|cellular response to UV|cellular response to drug|response to drug|negative regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|fibroblast apoptotic process|protein-containing complex binding|negative regulation of monocyte differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|positive regulation of fibroblast proliferation|negative regulation of fibroblast proliferation|positive regulation of epithelial cell proliferation|chromosome organization|negative regulation of cell division|positive regulation of telomerase activity|ERK1 and ERK2 cascade|repressing transcription factor binding|response to growth factor|E-box binding|cellular response to hypoxia|positive regulation of metanephric cap mesenchymal cell proliferation|regulation of somatic stem cell population maintenance|beta-catenin-TCF complex assembly|positive regulation of DNA methylation|positive regulation of DNA biosynthetic process|positive regulation of response to DNA damage stimulus" "hsa04010,hsa04012,hsa04110,hsa04151,hsa04218,hsa04310,hsa04350,hsa04390,hsa04550,hsa04630,hsa04919,hsa05132,hsa05160,hsa05161,hsa05163,hsa05166,hsa05167,hsa05169,hsa05200,hsa05202,hsa05205,hsa05206,hsa05210,hsa05213,hsa05216,hsa05219,hsa05220,hsa05221,hsa05222,hsa05224,hsa05225,hsa05226,hsa05230" MAPK signaling pathway|ErbB signaling pathway|Cell cycle|PI3K-Akt signaling pathway|Cellular senescence|Wnt signaling pathway|TGF-beta signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|JAK-STAT signaling pathway|Thyroid hormone signaling pathway|Salmonella infection|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Endometrial cancer|Thyroid cancer|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer bHLH MYCBP 597.4843025 482.7520415 712.2165634 1.475325845 0.561033627 0.033114193 0.924156292 10.17519321 14.76052461 26292 MYC binding protein "GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0006355,GO:0007283,GO:0045893" "transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|regulation of transcription, DNA-templated|spermatogenesis|positive regulation of transcription, DNA-templated" MYCBP2 2025.850374 2251.455642 1800.245106 0.799591638 -0.322664709 0.172606043 1 7.554133636 5.939147154 23077 MYC binding protein 2 "GO:0005085,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008270,GO:0015630,GO:0016020,GO:0016567,GO:0021785,GO:0021952,GO:0030424,GO:0031267,GO:0031398,GO:0032880,GO:0032922,GO:0042177,GO:0042802,GO:0043231,GO:0050790,GO:0050905,GO:0051493,GO:0061630,GO:1902667" guanyl-nucleotide exchange factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|zinc ion binding|microtubule cytoskeleton|membrane|protein ubiquitination|branchiomotor neuron axon guidance|central nervous system projection neuron axonogenesis|axon|small GTPase binding|positive regulation of protein ubiquitination|regulation of protein localization|circadian regulation of gene expression|negative regulation of protein catabolic process|identical protein binding|intracellular membrane-bounded organelle|regulation of catalytic activity|neuromuscular process|regulation of cytoskeleton organization|ubiquitin protein ligase activity|regulation of axon guidance MYCBPAP 9.606529142 12.48496659 6.728091692 0.53889545 -0.891922689 0.47680615 1 0.141916873 0.075198596 84073 MYCBP associated protein "GO:0005515,GO:0005737,GO:0007268,GO:0007275,GO:0007283,GO:0016020,GO:0030154,GO:0045202" protein binding|cytoplasm|chemical synaptic transmission|multicellular organism development|spermatogenesis|membrane|cell differentiation|synapse MYCL 16.89445674 14.56579436 19.22311912 1.31974396 0.400258063 0.706666422 1 0.160311337 0.208029583 4610 "MYCL proto-oncogene, bHLH transcription factor" "GO:0000785,GO:0000978,GO:0000981,GO:0003677,GO:0005654,GO:0005694,GO:0006357,GO:0045607,GO:0046983" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleoplasm|chromosome|regulation of transcription by RNA polymerase II|regulation of inner ear auditory receptor cell differentiation|protein dimerization activity" MYCT1 8.605744223 11.44455271 5.766935736 0.503902239 -0.988784228 0.453166672 1 0.104388095 0.051721182 80177 MYC target 1 "GO:0005654,GO:0043231,GO:0061484" nucleoplasm|intracellular membrane-bounded organelle|hematopoietic stem cell homeostasis MYD88 831.4742448 809.4420007 853.5064889 1.054438105 0.076474411 0.76397458 1 16.01721612 16.60654574 4615 MYD88 innate immune signal transduction adaptor "GO:0002224,GO:0002238,GO:0002755,GO:0005121,GO:0005123,GO:0005149,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006909,GO:0006915,GO:0006954,GO:0007165,GO:0007166,GO:0007254,GO:0008063,GO:0009615,GO:0009682,GO:0010008,GO:0010628,GO:0014069,GO:0016064,GO:0031663,GO:0032481,GO:0032494,GO:0032722,GO:0032740,GO:0032747,GO:0032755,GO:0032757,GO:0032760,GO:0032991,GO:0034162,GO:0035325,GO:0042742,GO:0042802,GO:0042832,GO:0043066,GO:0043123,GO:0043621,GO:0045087,GO:0046330,GO:0048661,GO:0050671,GO:0050727,GO:0050830,GO:0051092,GO:0060337,GO:0070498,GO:0070555,GO:0070935,GO:0070976,GO:0071222,GO:0071260,GO:0090557,GO:0140052,GO:1900017,GO:1902622,GO:2000338,GO:2000341" toll-like receptor signaling pathway|response to molecule of fungal origin|MyD88-dependent toll-like receptor signaling pathway|Toll binding|death receptor binding|interleukin-1 receptor binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|phagocytosis|apoptotic process|inflammatory response|signal transduction|cell surface receptor signaling pathway|JNK cascade|Toll signaling pathway|response to virus|induced systemic resistance|endosome membrane|positive regulation of gene expression|postsynaptic density|immunoglobulin mediated immune response|lipopolysaccharide-mediated signaling pathway|positive regulation of type I interferon production|response to peptidoglycan|positive regulation of chemokine production|positive regulation of interleukin-17 production|positive regulation of interleukin-23 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|protein-containing complex|toll-like receptor 9 signaling pathway|Toll-like receptor binding|defense response to bacterium|identical protein binding|defense response to protozoan|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|protein self-association|innate immune response|positive regulation of JNK cascade|positive regulation of smooth muscle cell proliferation|positive regulation of lymphocyte proliferation|regulation of inflammatory response|defense response to Gram-positive bacterium|positive regulation of NF-kappaB transcription factor activity|type I interferon signaling pathway|interleukin-1-mediated signaling pathway|response to interleukin-1|3'-UTR-mediated mRNA stabilization|TIR domain binding|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|establishment of endothelial intestinal barrier|cellular response to oxidised low-density lipoprotein particle stimulus|positive regulation of cytokine production involved in inflammatory response|regulation of neutrophil migration|regulation of chemokine (C-X-C motif) ligand 1 production|regulation of chemokine (C-X-C motif) ligand 2 production "hsa04010,hsa04064,hsa04620,hsa04621,hsa05130,hsa05131,hsa05132,hsa05133,hsa05134,hsa05135,hsa05140,hsa05142,hsa05143,hsa05144,hsa05145,hsa05152,hsa05161,hsa05162,hsa05164,hsa05168,hsa05169,hsa05170,hsa05171,hsa05235" MAPK signaling pathway|NF-kappa B signaling pathway|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Leishmaniasis|Chagas disease|African trypanosomiasis|Malaria|Toxoplasmosis|Tuberculosis|Hepatitis B|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|PD-L1 expression and PD-1 checkpoint pathway in cancer MYDGF 1620.104051 1402.477914 1837.730188 1.31034519 0.389946917 0.101222252 1 53.00826389 68.29681923 56005 myeloid derived growth factor "GO:0001525,GO:0001934,GO:0001938,GO:0005515,GO:0005615,GO:0005783,GO:0005788,GO:0005793,GO:0005794,GO:0006915,GO:0014068,GO:0036498,GO:0043066,GO:0043410,GO:0045766,GO:0045944,GO:0051897" angiogenesis|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|protein binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|apoptotic process|positive regulation of phosphatidylinositol 3-kinase signaling|IRE1-mediated unfolded protein response|negative regulation of apoptotic process|positive regulation of MAPK cascade|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|positive regulation of protein kinase B signaling MYEF2 27.02622324 15.60620824 38.44623824 2.463522058 1.300722389 0.088886855 1 0.074959468 0.181574196 50804 myelin expression factor 2 "GO:0003697,GO:0003723,GO:0003729,GO:0005634,GO:0005737,GO:0006357,GO:0014902,GO:0030182,GO:0071014,GO:1990904,GO:2000815" single-stranded DNA binding|RNA binding|mRNA binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|myotube differentiation|neuron differentiation|post-mRNA release spliceosomal complex|ribonucleoprotein complex|regulation of mRNA stability involved in response to oxidative stress MYEOV 289.1721215 337.094098 241.250145 0.715675968 -0.482621559 0.130706495 1 7.555687718 5.316938204 26579 myeloma overexpressed GO:0005515 protein binding MYG1 812.4989603 790.7145508 834.2833698 1.055100566 0.077380514 0.76192282 1 35.10730641 36.42189552 60314 MYG1 exonuclease "GO:0003674,GO:0004518,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005759,GO:0035641,GO:0090305" molecular_function|nuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|mitochondrial matrix|locomotory exploration behavior|nucleic acid phosphodiester bond hydrolysis MYH10 5296.465794 5526.678545 5066.253044 0.916690378 -0.125493565 0.602301857 1 35.33165744 31.84621791 4628 myosin heavy chain 10 "GO:0000146,GO:0000281,GO:0001725,GO:0003779,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0005938,GO:0007155,GO:0008360,GO:0016459,GO:0016460,GO:0016887,GO:0030027,GO:0030048,GO:0030496,GO:0030898,GO:0031032,GO:0032154,GO:0035613,GO:0042641,GO:0043531,GO:0048027,GO:0050714,GO:0051015,GO:0070062,GO:0097513,GO:0098885" microfilament motor activity|mitotic cytokinesis|stress fiber|actin binding|protein binding|calmodulin binding|ATP binding|nucleus|cytoplasm|cytosol|polysome|cell cortex|cell adhesion|regulation of cell shape|myosin complex|myosin II complex|ATPase activity|lamellipodium|actin filament-based movement|midbody|actin-dependent ATPase activity|actomyosin structure organization|cleavage furrow|RNA stem-loop binding|actomyosin|ADP binding|mRNA 5'-UTR binding|positive regulation of protein secretion|actin filament binding|extracellular exosome|myosin II filament|modification of postsynaptic actin cytoskeleton "hsa04270,hsa04530,hsa04810,hsa05130" Vascular smooth muscle contraction|Tight junction|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection MYH15 29.18630893 21.84869154 36.52392633 1.671675682 0.741294981 0.320933888 1 0.156534369 0.257295926 22989 myosin heavy chain 15 "GO:0002074,GO:0003774,GO:0005516,GO:0005524,GO:0005829,GO:0016459,GO:0030016,GO:0032982,GO:0043231,GO:0051015" extraocular skeletal muscle development|motor activity|calmodulin binding|ATP binding|cytosol|myosin complex|myofibril|myosin filament|intracellular membrane-bounded organelle|actin filament binding MYH3 13.97135991 13.52538047 14.41733934 1.065947044 0.092135768 1 1 0.117637663 0.123297194 4621 myosin heavy chain 3 "GO:0000146,GO:0003009,GO:0005516,GO:0005524,GO:0005829,GO:0005859,GO:0006470,GO:0007517,GO:0016887,GO:0017018,GO:0030017,GO:0030048,GO:0030049,GO:0030326,GO:0032982,GO:0045214,GO:0046034,GO:0051015,GO:0060325,GO:0070062" microfilament motor activity|skeletal muscle contraction|calmodulin binding|ATP binding|cytosol|muscle myosin complex|protein dephosphorylation|muscle organ development|ATPase activity|myosin phosphatase activity|sarcomere|actin filament-based movement|muscle filament sliding|embryonic limb morphogenesis|myosin filament|sarcomere organization|ATP metabolic process|actin filament binding|face morphogenesis|extracellular exosome MYH7B 7.124381325 10.40413883 3.844623824 0.369528309 -1.436243205 0.311438224 1 0.071103825 0.025835202 57644 myosin heavy chain 7B "GO:0003774,GO:0005515,GO:0005524,GO:0016020,GO:0016459,GO:0032982,GO:0051015,GO:0097512" motor activity|protein binding|ATP binding|membrane|myosin complex|myosin filament|actin filament binding|cardiac myofibril MYH9 33007.09356 33007.13043 33007.05668 0.999997766 -3.22E-06 1 1 236.415231 232.458623 4627 myosin heavy chain 9 "GO:0000146,GO:0000212,GO:0001525,GO:0001701,GO:0001725,GO:0001726,GO:0001768,GO:0001772,GO:0001778,GO:0001931,GO:0003723,GO:0003774,GO:0003779,GO:0005178,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005819,GO:0005826,GO:0005829,GO:0005886,GO:0005903,GO:0005912,GO:0005925,GO:0006509,GO:0006911,GO:0007229,GO:0007520,GO:0008180,GO:0008360,GO:0009898,GO:0015031,GO:0015629,GO:0016020,GO:0016460,GO:0016887,GO:0019904,GO:0030048,GO:0030220,GO:0030224,GO:0030898,GO:0031032,GO:0031252,GO:0031532,GO:0031594,GO:0032154,GO:0032418,GO:0032506,GO:0032796,GO:0032991,GO:0042641,GO:0042802,GO:0042803,GO:0043495,GO:0043531,GO:0043534,GO:0045055,GO:0045296,GO:0050900,GO:0051015,GO:0051295,GO:0070062,GO:0070527,GO:0097513,GO:1903919,GO:1903923,GO:1905684" "microfilament motor activity|meiotic spindle organization|angiogenesis|in utero embryonic development|stress fiber|ruffle|establishment of T cell polarity|immunological synapse|plasma membrane repair|uropod|RNA binding|motor activity|actin binding|integrin binding|protein binding|calmodulin binding|ATP binding|nucleus|cytoplasm|spindle|actomyosin contractile ring|cytosol|plasma membrane|brush border|adherens junction|focal adhesion|membrane protein ectodomain proteolysis|phagocytosis, engulfment|integrin-mediated signaling pathway|myoblast fusion|COP9 signalosome|regulation of cell shape|cytoplasmic side of plasma membrane|protein transport|actin cytoskeleton|membrane|myosin II complex|ATPase activity|protein domain specific binding|actin filament-based movement|platelet formation|monocyte differentiation|actin-dependent ATPase activity|actomyosin structure organization|cell leading edge|actin cytoskeleton reorganization|neuromuscular junction|cleavage furrow|lysosome localization|cytokinetic process|uropod organization|protein-containing complex|actomyosin|identical protein binding|protein homodimerization activity|protein-membrane adaptor activity|ADP binding|blood vessel endothelial cell migration|regulated exocytosis|cadherin binding|leukocyte migration|actin filament binding|establishment of meiotic spindle localization|extracellular exosome|platelet aggregation|myosin II filament|negative regulation of actin filament severing|positive regulation of protein processing in phagocytic vesicle|regulation of plasma membrane repair" "hsa04270,hsa04530,hsa04810,hsa05130" Vascular smooth muscle contraction|Tight junction|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection MYL12A 12851.68195 10372.92641 15330.4375 1.477927915 0.563575904 0.029205773 0.88444427 462.0901652 671.5079459 10627 myosin light chain 12A "GO:0005509,GO:0005515,GO:0005829,GO:0006936,GO:0016459,GO:0070062,GO:0070527" calcium ion binding|protein binding|cytosol|muscle contraction|myosin complex|extracellular exosome|platelet aggregation "hsa04360,hsa04510,hsa04530,hsa04611,hsa04670,hsa04810,hsa05131,hsa05132" Axon guidance|Focal adhesion|Tight junction|Platelet activation|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Shigellosis|Salmonella infection MYL12B 16419.45554 13248.63038 19590.2807 1.478664596 0.564294845 0.034119731 0.939345539 610.5829478 887.7394596 103910 myosin light chain 12B "GO:0005509,GO:0005515,GO:0005829,GO:0006936,GO:0016459,GO:0070062,GO:0099738" calcium ion binding|protein binding|cytosol|muscle contraction|myosin complex|extracellular exosome|cell cortex region "hsa04360,hsa04510,hsa04530,hsa04611,hsa04670,hsa04810,hsa05131,hsa05132" Axon guidance|Focal adhesion|Tight junction|Platelet activation|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Shigellosis|Salmonella infection MYL5 32.42643747 31.21241648 33.64045846 1.0777909 0.108077311 0.923948662 1 0.62340917 0.660661315 4636 myosin light chain 5 "GO:0005509,GO:0005829,GO:0005859,GO:0006936,GO:0006937,GO:0008307" calcium ion binding|cytosol|muscle myosin complex|muscle contraction|regulation of muscle contraction|structural constituent of muscle "hsa04360,hsa04510,hsa04670,hsa04810,hsa05131,hsa05132" Axon guidance|Focal adhesion|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Shigellosis|Salmonella infection MYL6 11909.31934 9352.280391 14466.35829 1.546826837 0.6293117 0.014148243 0.708244576 704.963299 1072.208843 4637 myosin light chain 6 "GO:0003774,GO:0005509,GO:0005515,GO:0005829,GO:0005903,GO:0006936,GO:0007519,GO:0008307,GO:0016020,GO:0016459,GO:0016461,GO:0030049,GO:0030898,GO:0031982,GO:0070062" motor activity|calcium ion binding|protein binding|cytosol|brush border|muscle contraction|skeletal muscle tissue development|structural constituent of muscle|membrane|myosin complex|unconventional myosin complex|muscle filament sliding|actin-dependent ATPase activity|vesicle|extracellular exosome "hsa04270,hsa04530,hsa04921" Vascular smooth muscle contraction|Tight junction|Oxytocin signaling pathway MYL6B 1473.56298 1315.083148 1632.042813 1.241018727 0.311524885 0.192236397 1 78.68113293 96.01080658 140465 myosin light chain 6B "GO:0003774,GO:0005509,GO:0005515,GO:0005829,GO:0005859,GO:0006936,GO:0007519,GO:0008307,GO:0016459,GO:0016461,GO:0030049,GO:0070062" motor activity|calcium ion binding|protein binding|cytosol|muscle myosin complex|muscle contraction|skeletal muscle tissue development|structural constituent of muscle|myosin complex|unconventional myosin complex|muscle filament sliding|extracellular exosome "hsa04270,hsa04530,hsa04921" Vascular smooth muscle contraction|Tight junction|Oxytocin signaling pathway MYL9 2280.628971 1773.90567 2787.352272 1.571308058 0.651966051 0.005949208 0.464919713 33.98064799 52.5005886 10398 myosin light chain 9 "GO:0001725,GO:0005509,GO:0005829,GO:0005859,GO:0006936,GO:0006937,GO:0008307,GO:0030018,GO:0032036,GO:0045652,GO:0070527" stress fiber|calcium ion binding|cytosol|muscle myosin complex|muscle contraction|regulation of muscle contraction|structural constituent of muscle|Z disc|myosin heavy chain binding|regulation of megakaryocyte differentiation|platelet aggregation "hsa04022,hsa04024,hsa04270,hsa04360,hsa04510,hsa04530,hsa04670,hsa04810,hsa04921,hsa05131,hsa05132" cGMP-PKG signaling pathway|cAMP signaling pathway|Vascular smooth muscle contraction|Axon guidance|Focal adhesion|Tight junction|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Shigellosis|Salmonella infection MYLIP 38.34685864 47.8590386 28.83467868 0.602491808 -0.73098647 0.272739528 1 0.794694751 0.470785056 29116 myosin regulatory light chain interacting protein "GO:0000209,GO:0004842,GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0006511,GO:0007399,GO:0008092,GO:0010977,GO:0010989,GO:0016567,GO:0031648,GO:0032802,GO:0032803,GO:0042632,GO:0045732,GO:0046872,GO:0061630" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytosol|cytoskeleton|plasma membrane|ubiquitin-dependent protein catabolic process|nervous system development|cytoskeletal protein binding|negative regulation of neuron projection development|negative regulation of low-density lipoprotein particle clearance|protein ubiquitination|protein destabilization|low-density lipoprotein particle receptor catabolic process|regulation of low-density lipoprotein particle receptor catabolic process|cholesterol homeostasis|positive regulation of protein catabolic process|metal ion binding|ubiquitin protein ligase activity hsa04979 Cholesterol metabolism MYLK 81.04848721 121.7284243 40.36855015 0.331627969 -1.592362407 0.001909182 0.274821698 0.60533193 0.197385803 4638 myosin light chain kinase "GO:0001725,GO:0003779,GO:0004672,GO:0004687,GO:0005515,GO:0005516,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0006936,GO:0006939,GO:0014820,GO:0015629,GO:0030027,GO:0030335,GO:0032060,GO:0032154,GO:0046872,GO:0051928,GO:0060414,GO:0071476,GO:0090303" stress fiber|actin binding|protein kinase activity|myosin light chain kinase activity|protein binding|calmodulin binding|ATP binding|cytoplasm|cytosol|plasma membrane|protein phosphorylation|muscle contraction|smooth muscle contraction|tonic smooth muscle contraction|actin cytoskeleton|lamellipodium|positive regulation of cell migration|bleb assembly|cleavage furrow|metal ion binding|positive regulation of calcium ion transport|aorta smooth muscle tissue morphogenesis|cellular hypotonic response|positive regulation of wound healing "hsa04020,hsa04022,hsa04270,hsa04371,hsa04510,hsa04611,hsa04810,hsa04921,hsa04971" Calcium signaling pathway|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Apelin signaling pathway|Focal adhesion|Platelet activation|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Gastric acid secretion MYLK3 8.486857333 8.323311061 8.650403604 1.039298368 0.055609892 1 1 0.054880135 0.056082401 91807 myosin light chain kinase 3 "GO:0002528,GO:0004683,GO:0004687,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0015629,GO:0045214,GO:0048769,GO:0055003,GO:0060298,GO:0071347" regulation of vascular permeability involved in acute inflammatory response|calmodulin-dependent protein kinase activity|myosin light chain kinase activity|ATP binding|cytoplasm|cytosol|protein phosphorylation|actin cytoskeleton|sarcomere organization|sarcomerogenesis|cardiac myofibril assembly|positive regulation of sarcomere organization|cellular response to interleukin-1 "hsa04020,hsa04022,hsa04270,hsa04371,hsa04510,hsa04611,hsa04810,hsa04921,hsa04971" Calcium signaling pathway|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Apelin signaling pathway|Focal adhesion|Platelet activation|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Gastric acid secretion MYLK4 6.044338479 7.282897178 4.80577978 0.65987198 -0.599741937 0.771875613 1 0.04592094 0.02979488 340156 myosin light chain kinase family member 4 "GO:0004687,GO:0005515,GO:0005524,GO:0006468,GO:0106310,GO:0106311" myosin light chain kinase activity|protein binding|ATP binding|protein phosphorylation|protein serine kinase activity|protein threonine kinase activity "hsa04020,hsa04022,hsa04270,hsa04371,hsa04510,hsa04611,hsa04810,hsa04921,hsa04971" Calcium signaling pathway|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Apelin signaling pathway|Focal adhesion|Platelet activation|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Gastric acid secretion MYNN 485.811574 528.5302524 443.0928957 0.838349165 -0.254376856 0.35653742 1 5.60101036 4.617027811 55892 myoneurin "GO:0000978,GO:0000981,GO:0005515,GO:0005654,GO:0006357,GO:0046872,GO:1990830" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding|cellular response to leukemia inhibitory factor" ZBTB MYO10 4335.782083 4454.011832 4217.552335 0.946910896 -0.07869942 0.742274523 1 17.02983417 15.85589319 4651 myosin X "GO:0001726,GO:0005515,GO:0005516,GO:0005524,GO:0005547,GO:0005730,GO:0005829,GO:0005886,GO:0005938,GO:0008360,GO:0016459,GO:0030027,GO:0030507,GO:0030705,GO:0030898,GO:0031527,GO:0032433,GO:0038096,GO:0051015,GO:0051489,GO:0060002" "ruffle|protein binding|calmodulin binding|ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleolus|cytosol|plasma membrane|cell cortex|regulation of cell shape|myosin complex|lamellipodium|spectrin binding|cytoskeleton-dependent intracellular transport|actin-dependent ATPase activity|filopodium membrane|filopodium tip|Fc-gamma receptor signaling pathway involved in phagocytosis|actin filament binding|regulation of filopodium assembly|plus-end directed microfilament motor activity" "hsa04666,hsa05130" Fc gamma R-mediated phagocytosis|Pathogenic Escherichia coli infection MYO15A 5.563760501 7.282897178 3.844623824 0.527897584 -0.921670032 0.614283311 1 0.028572729 0.014831073 51168 myosin XVA "GO:0000146,GO:0005516,GO:0005524,GO:0005737,GO:0007015,GO:0007605,GO:0015629,GO:0016459,GO:0030050,GO:0030898,GO:0031982,GO:0032420,GO:0051015,GO:0070062,GO:0098858" microfilament motor activity|calmodulin binding|ATP binding|cytoplasm|actin filament organization|sensory perception of sound|actin cytoskeleton|myosin complex|vesicle transport along actin filament|actin-dependent ATPase activity|vesicle|stereocilium|actin filament binding|extracellular exosome|actin-based cell projection MYO15B 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.013469308 0.016313341 80022 myosin XVB MYO16 3.081612685 5.202069413 0.961155956 0.184764154 -2.436243205 0.338470402 1 0.036640476 0.006656562 23026 myosin XVI "GO:0003774,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005886,GO:0008285,GO:0014065,GO:0016459,GO:0019903,GO:0021549,GO:0048471,GO:0048812,GO:0051015,GO:2000134" motor activity|protein binding|ATP binding|nucleoplasm|cytoplasm|plasma membrane|negative regulation of cell population proliferation|phosphatidylinositol 3-kinase signaling|myosin complex|protein phosphatase binding|cerebellum development|perinuclear region of cytoplasm|neuron projection morphogenesis|actin filament binding|negative regulation of G1/S transition of mitotic cell cycle MYO18A 1201.714975 1218.324657 1185.105294 0.972733571 -0.039883386 0.872430469 1 6.27724925 6.003913914 399687 myosin XVIIIA "GO:0000139,GO:0003677,GO:0003723,GO:0005515,GO:0005524,GO:0005793,GO:0005802,GO:0006259,GO:0007030,GO:0009986,GO:0016020,GO:0016459,GO:0016477,GO:0016887,GO:0031032,GO:0042641,GO:0043030,GO:0043066,GO:0043531,GO:0048194,GO:0050714,GO:0051015,GO:0090161,GO:0090164,GO:0150051,GO:1903028" Golgi membrane|DNA binding|RNA binding|protein binding|ATP binding|endoplasmic reticulum-Golgi intermediate compartment|trans-Golgi network|DNA metabolic process|Golgi organization|cell surface|membrane|myosin complex|cell migration|ATPase activity|actomyosin structure organization|actomyosin|regulation of macrophage activation|negative regulation of apoptotic process|ADP binding|Golgi vesicle budding|positive regulation of protein secretion|actin filament binding|Golgi ribbon formation|asymmetric Golgi ribbon formation|postsynaptic Golgi apparatus|positive regulation of opsonization MYO19 1902.303433 2048.574935 1756.031932 0.857196826 -0.222301587 0.34808651 1 23.35084988 19.68132916 80179 myosin XIX "GO:0000146,GO:0003779,GO:0005524,GO:0005737,GO:0005739,GO:0005741,GO:0005829,GO:0007015,GO:0015629,GO:0016459,GO:0016887,GO:0030050,GO:0030898,GO:0031982,GO:0032027,GO:0032465,GO:0034642,GO:0051015,GO:0060002,GO:0090140" microfilament motor activity|actin binding|ATP binding|cytoplasm|mitochondrion|mitochondrial outer membrane|cytosol|actin filament organization|actin cytoskeleton|myosin complex|ATPase activity|vesicle transport along actin filament|actin-dependent ATPase activity|vesicle|myosin light chain binding|regulation of cytokinesis|mitochondrion migration along actin filament|actin filament binding|plus-end directed microfilament motor activity|regulation of mitochondrial fission MYO1B 6156.69619 7027.995777 5285.396602 0.752048915 -0.411101593 0.09031549 1 70.42268451 52.07506782 4430 myosin IB "GO:0000146,GO:0005515,GO:0005516,GO:0005524,GO:0005546,GO:0005547,GO:0005737,GO:0005769,GO:0005884,GO:0005886,GO:0005902,GO:0005903,GO:0006892,GO:0007015,GO:0010008,GO:0015629,GO:0016459,GO:0030048,GO:0030050,GO:0030175,GO:0030898,GO:0031982,GO:0032588,GO:0045177,GO:0045296,GO:0048471,GO:0051015,GO:0051017,GO:0070062,GO:0071944" "microfilament motor activity|protein binding|calmodulin binding|ATP binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|early endosome|actin filament|plasma membrane|microvillus|brush border|post-Golgi vesicle-mediated transport|actin filament organization|endosome membrane|actin cytoskeleton|myosin complex|actin filament-based movement|vesicle transport along actin filament|filopodium|actin-dependent ATPase activity|vesicle|trans-Golgi network membrane|apical part of cell|cadherin binding|perinuclear region of cytoplasm|actin filament binding|actin filament bundle assembly|extracellular exosome|cell periphery" hsa05130 Pathogenic Escherichia coli infection MYO1C 7727.349784 8507.464318 6947.23525 0.816604689 -0.292290244 0.235023156 1 76.87567467 61.72654768 4641 myosin IC "GO:0000146,GO:0001725,GO:0005102,GO:0005515,GO:0005516,GO:0005524,GO:0005643,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0005902,GO:0005903,GO:0006605,GO:0006612,GO:0007015,GO:0008022,GO:0009925,GO:0015629,GO:0016020,GO:0016328,GO:0016461,GO:0016604,GO:0030050,GO:0030335,GO:0030659,GO:0030838,GO:0030898,GO:0031267,GO:0031941,GO:0031982,GO:0032587,GO:0038089,GO:0038096,GO:0045121,GO:0045335,GO:0045815,GO:0051015,GO:0051028,GO:0060171,GO:0070062,GO:0071346,GO:0090314,GO:1900078,GO:1900748,GO:2000810" "microfilament motor activity|stress fiber|signaling receptor binding|protein binding|calmodulin binding|ATP binding|nuclear pore|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|microvillus|brush border|protein targeting|protein targeting to membrane|actin filament organization|protein C-terminus binding|basal plasma membrane|actin cytoskeleton|membrane|lateral plasma membrane|unconventional myosin complex|nuclear body|vesicle transport along actin filament|positive regulation of cell migration|cytoplasmic vesicle membrane|positive regulation of actin filament polymerization|actin-dependent ATPase activity|small GTPase binding|filamentous actin|vesicle|ruffle membrane|positive regulation of cell migration by vascular endothelial growth factor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|membrane raft|phagocytic vesicle|positive regulation of gene expression, epigenetic|actin filament binding|mRNA transport|stereocilium membrane|extracellular exosome|cellular response to interferon-gamma|positive regulation of protein targeting to membrane|positive regulation of cellular response to insulin stimulus|positive regulation of vascular endothelial growth factor signaling pathway|regulation of bicellular tight junction assembly" hsa05130 Pathogenic Escherichia coli infection MYO1D 2964.905503 2932.926735 2996.884271 1.021806728 0.03112234 0.896775544 1 20.35169801 20.44751739 4642 myosin ID "GO:0000146,GO:0005516,GO:0005524,GO:0005737,GO:0005768,GO:0005769,GO:0005790,GO:0005829,GO:0005886,GO:0005902,GO:0005903,GO:0005938,GO:0007015,GO:0010923,GO:0015031,GO:0015629,GO:0016323,GO:0016459,GO:0019904,GO:0030050,GO:0030424,GO:0030673,GO:0030898,GO:0030900,GO:0031410,GO:0031982,GO:0043005,GO:0043025,GO:0043204,GO:0043209,GO:0044853,GO:0048306,GO:0051015,GO:0051641,GO:0061502,GO:0070062,GO:0097440" microfilament motor activity|calmodulin binding|ATP binding|cytoplasm|endosome|early endosome|smooth endoplasmic reticulum|cytosol|plasma membrane|microvillus|brush border|cell cortex|actin filament organization|negative regulation of phosphatase activity|protein transport|actin cytoskeleton|basolateral plasma membrane|myosin complex|protein domain specific binding|vesicle transport along actin filament|axon|axolemma|actin-dependent ATPase activity|forebrain development|cytoplasmic vesicle|vesicle|neuron projection|neuronal cell body|perikaryon|myelin sheath|plasma membrane raft|calcium-dependent protein binding|actin filament binding|cellular localization|early endosome to recycling endosome transport|extracellular exosome|apical dendrite hsa05130 Pathogenic Escherichia coli infection MYO1E 1443.786653 1366.063428 1521.509878 1.113791532 0.155479229 0.516602414 1 8.434092368 9.236627794 4643 myosin IE "GO:0000146,GO:0001570,GO:0001701,GO:0003094,GO:0003774,GO:0005515,GO:0005516,GO:0005524,GO:0005737,GO:0005856,GO:0005886,GO:0005902,GO:0005903,GO:0005912,GO:0006807,GO:0006897,GO:0007015,GO:0015629,GO:0016459,GO:0016887,GO:0030048,GO:0030050,GO:0030898,GO:0031982,GO:0032836,GO:0035091,GO:0035166,GO:0045334,GO:0048008,GO:0051015,GO:0070062,GO:0072015" microfilament motor activity|vasculogenesis|in utero embryonic development|glomerular filtration|motor activity|protein binding|calmodulin binding|ATP binding|cytoplasm|cytoskeleton|plasma membrane|microvillus|brush border|adherens junction|nitrogen compound metabolic process|endocytosis|actin filament organization|actin cytoskeleton|myosin complex|ATPase activity|actin filament-based movement|vesicle transport along actin filament|actin-dependent ATPase activity|vesicle|glomerular basement membrane development|phosphatidylinositol binding|post-embryonic hemopoiesis|clathrin-coated endocytic vesicle|platelet-derived growth factor receptor signaling pathway|actin filament binding|extracellular exosome|glomerular visceral epithelial cell development hsa05130 Pathogenic Escherichia coli infection MYO1F 14.77400001 9.363724944 20.18427508 2.155581801 1.108077311 0.262451885 1 0.113085492 0.239685951 4542 myosin IF "GO:0000146,GO:0003779,GO:0005515,GO:0005516,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005902,GO:0007015,GO:0008150,GO:0015629,GO:0016461,GO:0030050,GO:0030898,GO:0031982,GO:0051015" microfilament motor activity|actin binding|protein binding|calmodulin binding|ATP binding|cytoplasm|cytosol|plasma membrane|microvillus|actin filament organization|biological_process|actin cytoskeleton|unconventional myosin complex|vesicle transport along actin filament|actin-dependent ATPase activity|vesicle|actin filament binding hsa05130 Pathogenic Escherichia coli infection MYO5A 1184.850701 1128.849063 1240.852339 1.099219001 0.136478848 0.575012398 1 4.923955843 5.321934869 4644 myosin VA "GO:0000146,GO:0001726,GO:0003723,GO:0005515,GO:0005516,GO:0005524,GO:0005737,GO:0005764,GO:0005769,GO:0005770,GO:0005777,GO:0005783,GO:0005829,GO:0005884,GO:0006892,GO:0007015,GO:0015031,GO:0015629,GO:0016020,GO:0016192,GO:0016459,GO:0030048,GO:0030050,GO:0030426,GO:0030898,GO:0031267,GO:0031982,GO:0032402,GO:0032433,GO:0032593,GO:0032869,GO:0042470,GO:0043005,GO:0051015,GO:0055037,GO:0070062,GO:0072659,GO:1903358" microfilament motor activity|ruffle|RNA binding|protein binding|calmodulin binding|ATP binding|cytoplasm|lysosome|early endosome|late endosome|peroxisome|endoplasmic reticulum|cytosol|actin filament|post-Golgi vesicle-mediated transport|actin filament organization|protein transport|actin cytoskeleton|membrane|vesicle-mediated transport|myosin complex|actin filament-based movement|vesicle transport along actin filament|growth cone|actin-dependent ATPase activity|small GTPase binding|vesicle|melanosome transport|filopodium tip|insulin-responsive compartment|cellular response to insulin stimulus|melanosome|neuron projection|actin filament binding|recycling endosome|extracellular exosome|protein localization to plasma membrane|regulation of Golgi organization hsa05130 Pathogenic Escherichia coli infection MYO5B 203.9273802 193.5169822 214.3377782 1.10759157 0.147425979 0.692388755 1 1.07770486 1.173682588 4645 myosin VB "GO:0000146,GO:0003091,GO:0005515,GO:0005516,GO:0005524,GO:0005737,GO:0007015,GO:0015031,GO:0015629,GO:0016192,GO:0016197,GO:0016459,GO:0030050,GO:0030659,GO:0030898,GO:0031267,GO:0031982,GO:0032991,GO:0045179,GO:0051015,GO:0055037,GO:0070062" microfilament motor activity|renal water homeostasis|protein binding|calmodulin binding|ATP binding|cytoplasm|actin filament organization|protein transport|actin cytoskeleton|vesicle-mediated transport|endosomal transport|myosin complex|vesicle transport along actin filament|cytoplasmic vesicle membrane|actin-dependent ATPase activity|small GTPase binding|vesicle|protein-containing complex|apical cortex|actin filament binding|recycling endosome|extracellular exosome hsa05130 Pathogenic Escherichia coli infection MYO5C 15.17028964 19.76786377 10.57271552 0.534843605 -0.902811005 0.357772545 1 0.151120836 0.079473499 55930 myosin VC "GO:0000146,GO:0005516,GO:0005524,GO:0005737,GO:0007015,GO:0015629,GO:0016459,GO:0030050,GO:0030898,GO:0031982,GO:0051015,GO:0070062" microfilament motor activity|calmodulin binding|ATP binding|cytoplasm|actin filament organization|actin cytoskeleton|myosin complex|vesicle transport along actin filament|actin-dependent ATPase activity|vesicle|actin filament binding|extracellular exosome hsa05130 Pathogenic Escherichia coli infection MYO6 2022.680671 2067.302385 1978.058957 0.956830975 -0.063664 0.789503637 1 12.42573812 11.69037927 4646 myosin VI "GO:0000146,GO:0001726,GO:0003774,GO:0003779,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005765,GO:0005794,GO:0005829,GO:0005884,GO:0005886,GO:0005902,GO:0005905,GO:0005938,GO:0006886,GO:0006897,GO:0007015,GO:0007605,GO:0015629,GO:0016020,GO:0016461,GO:0016591,GO:0030048,GO:0030050,GO:0030139,GO:0030175,GO:0030330,GO:0030665,GO:0030898,GO:0031410,GO:0031941,GO:0031965,GO:0031982,GO:0032587,GO:0042472,GO:0042491,GO:0043531,GO:0045334,GO:0045944,GO:0048471,GO:0051015,GO:0051046,GO:0060001,GO:0070062" "microfilament motor activity|ruffle|motor activity|actin binding|protein binding|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|lysosomal membrane|Golgi apparatus|cytosol|actin filament|plasma membrane|microvillus|clathrin-coated pit|cell cortex|intracellular protein transport|endocytosis|actin filament organization|sensory perception of sound|actin cytoskeleton|membrane|unconventional myosin complex|RNA polymerase II, holoenzyme|actin filament-based movement|vesicle transport along actin filament|endocytic vesicle|filopodium|DNA damage response, signal transduction by p53 class mediator|clathrin-coated vesicle membrane|actin-dependent ATPase activity|cytoplasmic vesicle|filamentous actin|nuclear membrane|vesicle|ruffle membrane|inner ear morphogenesis|inner ear auditory receptor cell differentiation|ADP binding|clathrin-coated endocytic vesicle|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|actin filament binding|regulation of secretion|minus-end directed microfilament motor activity|extracellular exosome" "hsa05130,hsa05132" Pathogenic Escherichia coli infection|Salmonella infection MYO7A 117.4189281 105.0818021 129.7560541 1.234809942 0.304289004 0.499356407 1 0.63174751 0.767034389 4647 myosin VIIA "GO:0000146,GO:0001750,GO:0001845,GO:0001917,GO:0005515,GO:0005516,GO:0005524,GO:0005737,GO:0005765,GO:0005829,GO:0005902,GO:0005938,GO:0006886,GO:0007015,GO:0007040,GO:0007423,GO:0007601,GO:0007605,GO:0015629,GO:0016324,GO:0019904,GO:0030048,GO:0030050,GO:0030507,GO:0030898,GO:0031477,GO:0031982,GO:0032391,GO:0032420,GO:0034613,GO:0042462,GO:0042470,GO:0042490,GO:0042802,GO:0043531,GO:0045202,GO:0047485,GO:0048563,GO:0050953,GO:0050957,GO:0051015,GO:0051904,GO:0060088,GO:0120044,GO:1990435" microfilament motor activity|photoreceptor outer segment|phagolysosome assembly|photoreceptor inner segment|protein binding|calmodulin binding|ATP binding|cytoplasm|lysosomal membrane|cytosol|microvillus|cell cortex|intracellular protein transport|actin filament organization|lysosome organization|sensory organ development|visual perception|sensory perception of sound|actin cytoskeleton|apical plasma membrane|protein domain specific binding|actin filament-based movement|vesicle transport along actin filament|spectrin binding|actin-dependent ATPase activity|myosin VII complex|vesicle|photoreceptor connecting cilium|stereocilium|cellular protein localization|eye photoreceptor cell development|melanosome|mechanoreceptor differentiation|identical protein binding|ADP binding|synapse|protein N-terminus binding|post-embryonic animal organ morphogenesis|sensory perception of light stimulus|equilibrioception|actin filament binding|pigment granule transport|auditory receptor cell stereocilium organization|stereocilium base|upper tip-link density MYO7B 260.8985075 137.3346325 384.4623824 2.799456884 1.485146961 1.08E-05 0.005657335 1.02264503 2.814944739 4648 myosin VIIB "GO:0000146,GO:0005515,GO:0005524,GO:0005737,GO:0005902,GO:0005903,GO:0007015,GO:0007423,GO:0007605,GO:0015629,GO:0016459,GO:0030050,GO:0030154,GO:0030898,GO:0031982,GO:0051015,GO:0090651,GO:1904970" microfilament motor activity|protein binding|ATP binding|cytoplasm|microvillus|brush border|actin filament organization|sensory organ development|sensory perception of sound|actin cytoskeleton|myosin complex|vesicle transport along actin filament|cell differentiation|actin-dependent ATPase activity|vesicle|actin filament binding|apical cytoplasm|brush border assembly MYO9A 915.7477693 977.9890497 853.5064889 0.872715793 -0.19641619 0.429256189 1 4.018283017 3.448137182 4649 myosin IXA "GO:0003774,GO:0003779,GO:0005096,GO:0005515,GO:0005524,GO:0005829,GO:0007601,GO:0016021,GO:0016461,GO:0034329,GO:0035556,GO:0043547,GO:0044295,GO:0045198,GO:0045202,GO:0046872,GO:0051056,GO:0150011" motor activity|actin binding|GTPase activator activity|protein binding|ATP binding|cytosol|visual perception|integral component of membrane|unconventional myosin complex|cell junction assembly|intracellular signal transduction|positive regulation of GTPase activity|axonal growth cone|establishment of epithelial cell apical/basal polarity|synapse|metal ion binding|regulation of small GTPase mediated signal transduction|regulation of neuron projection arborization MYO9B 2540.785319 2560.458565 2521.112073 0.984633029 -0.02234196 0.926407688 1 17.96568074 17.3935911 4650 myosin IXB "GO:0000146,GO:0003779,GO:0005096,GO:0005515,GO:0005516,GO:0005524,GO:0005737,GO:0005829,GO:0005884,GO:0005938,GO:0007266,GO:0015629,GO:0016020,GO:0016459,GO:0016887,GO:0030048,GO:0031267,GO:0032011,GO:0035023,GO:0035385,GO:0042803,GO:0043531,GO:0043547,GO:0046872,GO:0048471,GO:0048495,GO:0051056" microfilament motor activity|actin binding|GTPase activator activity|protein binding|calmodulin binding|ATP binding|cytoplasm|cytosol|actin filament|cell cortex|Rho protein signal transduction|actin cytoskeleton|membrane|myosin complex|ATPase activity|actin filament-based movement|small GTPase binding|ARF protein signal transduction|regulation of Rho protein signal transduction|Roundabout signaling pathway|protein homodimerization activity|ADP binding|positive regulation of GTPase activity|metal ion binding|perinuclear region of cytoplasm|Roundabout binding|regulation of small GTPase mediated signal transduction MYOF 16895.60963 18065.74666 15725.4726 0.870457939 -0.200153508 0.452962485 1 113.6416426 97.2649732 26509 myoferlin "GO:0001778,GO:0005515,GO:0005543,GO:0005635,GO:0005886,GO:0005901,GO:0006936,GO:0007009,GO:0007520,GO:0008015,GO:0016021,GO:0030659,GO:0031410,GO:0031965,GO:0033292,GO:0043231,GO:0046872,GO:0061025,GO:0070062" plasma membrane repair|protein binding|phospholipid binding|nuclear envelope|plasma membrane|caveola|muscle contraction|plasma membrane organization|myoblast fusion|blood circulation|integral component of membrane|cytoplasmic vesicle membrane|cytoplasmic vesicle|nuclear membrane|T-tubule organization|intracellular membrane-bounded organelle|metal ion binding|membrane fusion|extracellular exosome MYOM1 7.68421723 12.48496659 2.883467868 0.230955193 -2.11431511 0.122989943 1 0.118770004 0.026971536 8736 myomesin 1 "GO:0002074,GO:0005515,GO:0005863,GO:0006936,GO:0008307,GO:0010628,GO:0010737,GO:0019900,GO:0031430,GO:0042802,GO:0042803,GO:0050714,GO:0051015" extraocular skeletal muscle development|protein binding|striated muscle myosin thick filament|muscle contraction|structural constituent of muscle|positive regulation of gene expression|protein kinase A signaling|kinase binding|M band|identical protein binding|protein homodimerization activity|positive regulation of protein secretion|actin filament binding MYOM2 16.77556985 11.44455271 22.10658699 1.93162525 0.949815228 0.311822274 1 0.121959813 0.231638531 9172 myomesin 2 "GO:0002074,GO:0005515,GO:0005739,GO:0006936,GO:0008307,GO:0019900,GO:0031430,GO:0032982,GO:0051015" extraocular skeletal muscle development|protein binding|mitochondrion|muscle contraction|structural constituent of muscle|kinase binding|M band|myosin filament|actin filament binding MYOM3 15.4527228 14.56579436 16.33965125 1.121782366 0.165792809 0.933361885 1 0.134956541 0.14885853 127294 myomesin 3 "GO:0006936,GO:0031430,GO:0042803,GO:0051015" muscle contraction|M band|protein homodimerization activity|actin filament binding MYORG 524.6987613 527.4898385 521.9076841 0.989417513 -0.015348659 0.962482677 1 3.668860054 3.569290681 57462 myogenesis regulating glycosidase (putative) "GO:0004553,GO:0005789,GO:0005975,GO:0016021,GO:0031965,GO:0043568,GO:0048741,GO:0051897" "hydrolase activity, hydrolyzing O-glycosyl compounds|endoplasmic reticulum membrane|carbohydrate metabolic process|integral component of membrane|nuclear membrane|positive regulation of insulin-like growth factor receptor signaling pathway|skeletal muscle fiber development|positive regulation of protein kinase B signaling" MYPN 891.6484445 1152.778582 630.5183071 0.546955258 -0.870505271 0.000489676 0.121751276 9.07533179 4.880737966 84665 myopalladin "GO:0003779,GO:0005515,GO:0005634,GO:0005886,GO:0007156,GO:0007411,GO:0008092,GO:0017124,GO:0030018,GO:0030424,GO:0031674,GO:0045214,GO:0051371,GO:0070593,GO:0098632" actin binding|protein binding|nucleus|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|axon guidance|cytoskeletal protein binding|SH3 domain binding|Z disc|axon|I band|sarcomere organization|muscle alpha-actinin binding|dendrite self-avoidance|cell-cell adhesion mediator activity MYPOP 96.83836339 94.67766332 98.99906347 1.045643291 0.064390777 0.914399909 1 1.703564694 1.751512998 339344 "Myb related transcription factor, partner of profilin" "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0042802" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|identical protein binding" MYRF 426.4727698 497.3178359 355.6277037 0.715091392 -0.483800457 0.088529391 1 4.287019685 3.014312029 745 myelin regulatory factor "GO:0000981,GO:0003700,GO:0005634,GO:0005654,GO:0005789,GO:0005794,GO:0005829,GO:0006357,GO:0008233,GO:0014003,GO:0016021,GO:0016540,GO:0022010,GO:0031643,GO:0032286,GO:0043565,GO:0045893,GO:0048709" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|endoplasmic reticulum membrane|Golgi apparatus|cytosol|regulation of transcription by RNA polymerase II|peptidase activity|oligodendrocyte development|integral component of membrane|protein autoprocessing|central nervous system myelination|positive regulation of myelination|central nervous system myelin maintenance|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|oligodendrocyte differentiation" MYSM1 1414.575192 1406.639569 1422.510815 1.011283093 0.016186914 0.949275669 1 9.618163808 9.563923523 114803 "Myb like, SWIRM and MPN domains 1" "GO:0003677,GO:0003713,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006338,GO:0008237,GO:0016579,GO:0018215,GO:0032991,GO:0035522,GO:0042393,GO:0045944,GO:0046872,GO:0070122,GO:1903706" DNA binding|transcription coactivator activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|nucleolus|chromatin remodeling|metallopeptidase activity|protein deubiquitination|protein phosphopantetheinylation|protein-containing complex|monoubiquitinated histone H2A deubiquitination|histone binding|positive regulation of transcription by RNA polymerase II|metal ion binding|isopeptidase activity|regulation of hemopoiesis MYZAP 51.56526824 41.61655531 61.51398118 1.478113235 0.563756795 0.348287047 1 0.926188102 1.346102348 100820829 myocardial zonula adherens protein "GO:0005515,GO:0005622,GO:0030018,GO:0030054,GO:0030864,GO:0031234,GO:0031674,GO:0035556" protein binding|intracellular anatomical structure|Z disc|cell junction|cortical actin cytoskeleton|extrinsic component of cytoplasmic side of plasma membrane|I band|intracellular signal transduction MZF1 120.4558814 121.7284243 119.1833385 0.9790921 -0.030483519 0.965456214 1 1.605640701 1.545763661 7593 myeloid zinc finger 1 "GO:0000122,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0003700,GO:0005515,GO:0005654,GO:0006355,GO:0042803,GO:0045944,GO:0046872" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|regulation of transcription, DNA-templated|protein homodimerization activity|positive regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 MZT1 916.5924959 571.1872216 1261.99777 2.209429277 1.143673752 5.10E-06 0.002792262 13.66347477 29.68331784 440145 mitotic spindle organizing protein 1 "GO:0005515,GO:0005813,GO:0005819,GO:0005829,GO:0008274,GO:0031021,GO:0033566,GO:0051415,GO:0090307" protein binding|centrosome|spindle|cytosol|gamma-tubulin ring complex|interphase microtubule organizing center|gamma-tubulin complex localization|microtubule nucleation by interphase microtubule organizing center|mitotic spindle assembly MZT2A 352.7669304 341.2557535 364.2781073 1.067463636 0.094186924 0.760950797 1 5.710941475 5.994210325 653784 mitotic spindle organizing protein 2A "GO:0005515,GO:0005654,GO:0005813,GO:0005819,GO:0005829,GO:0008274" protein binding|nucleoplasm|centrosome|spindle|cytosol|gamma-tubulin ring complex MZT2B 1508.526286 1311.961906 1705.090666 1.299649523 0.378122624 0.113063659 1 89.88061058 114.8585804 80097 mitotic spindle organizing protein 2B "GO:0005515,GO:0005654,GO:0005813,GO:0005819,GO:0005829,GO:0008274" protein binding|nucleoplasm|centrosome|spindle|cytosol|gamma-tubulin ring complex N4BP1 875.9446999 866.6647642 885.2246355 1.021415283 0.030569551 0.906991131 1 6.53558084 6.563835996 9683 NEDD4 binding protein 1 "GO:0005515,GO:0005634,GO:0005730,GO:0016605,GO:0031397,GO:0032435,GO:0034644" protein binding|nucleus|nucleolus|PML body|negative regulation of protein ubiquitination|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|cellular response to UV N4BP2 304.3870705 345.417409 263.3567319 0.762430396 -0.391322458 0.211782465 1 1.474389528 1.105308776 55728 NEDD4 binding protein 2 "GO:0004519,GO:0005515,GO:0005524,GO:0005829,GO:0016310,GO:0043130,GO:0046404,GO:0090305" endonuclease activity|protein binding|ATP binding|cytosol|phosphorylation|ubiquitin binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|nucleic acid phosphodiester bond hydrolysis N4BP2L1 148.4828896 138.3750464 158.5907327 1.146093439 0.196724669 0.639215913 1 1.281197416 1.443800736 90634 NEDD4 binding protein 2 like 1 N4BP2L2 1902.760702 1808.239328 1997.282077 1.104545203 0.143452462 0.545530296 1 7.746220062 8.412876302 10443 NEDD4 binding protein 2 like 2 "GO:0000122,GO:0003674,GO:0003714,GO:0005515,GO:0005634,GO:0017053,GO:0019899,GO:0070062,GO:1902035,GO:1902037" negative regulation of transcription by RNA polymerase II|molecular_function|transcription corepressor activity|protein binding|nucleus|transcription repressor complex|enzyme binding|extracellular exosome|positive regulation of hematopoietic stem cell proliferation|negative regulation of hematopoietic stem cell differentiation N4BP3 131.7073197 126.9304937 136.4841458 1.0752668 0.104694672 0.821559883 1 0.972723601 1.028435048 23138 NEDD4 binding protein 3 "GO:0005515,GO:0007399,GO:0030424,GO:0030425,GO:0031410" protein binding|nervous system development|axon|dendrite|cytoplasmic vesicle N6AMT1 272.8230238 261.1438845 284.502163 1.08944601 0.123594702 0.712383099 1 2.867058045 3.071237321 29104 N-6 adenine-specific DNA methyltransferase 1 "GO:0003676,GO:0005515,GO:0005634,GO:0005829,GO:0006415,GO:0008276,GO:0008757,GO:0009007,GO:0009404,GO:0018024,GO:0018364,GO:0018872,GO:0030307,GO:0030792,GO:0032259,GO:0032775,GO:0032991,GO:0034968,GO:0035657,GO:0036009,GO:1904047" nucleic acid binding|protein binding|nucleus|cytosol|translational termination|protein methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|site-specific DNA-methyltransferase (adenine-specific) activity|toxin metabolic process|histone-lysine N-methyltransferase activity|peptidyl-glutamine methylation|arsonoacetate metabolic process|positive regulation of cell growth|methylarsonite methyltransferase activity|methylation|DNA methylation on adenine|protein-containing complex|histone lysine methylation|eRF1 methyltransferase complex|protein-glutamine N-methyltransferase activity|S-adenosyl-L-methionine binding NAA10 2149.850782 2024.645416 2275.056148 1.123681278 0.168232886 0.477309159 1 67.40586693 74.475259 8260 "N-alpha-acetyltransferase 10, NatA catalytic subunit" "GO:0004596,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0006323,GO:0006473,GO:0006474,GO:0006475,GO:0008080,GO:0016020,GO:0016407,GO:0017198,GO:0018002,GO:0031415,GO:0043022,GO:1990189,GO:1990190,GO:2000719" "peptide alpha-N-acetyltransferase activity|protein binding|nucleus|nucleolus|cytoplasm|cytosol|DNA packaging|protein acetylation|N-terminal protein amino acid acetylation|internal protein amino acid acetylation|N-acetyltransferase activity|membrane|acetyltransferase activity|N-terminal peptidyl-serine acetylation|N-terminal peptidyl-glutamic acid acetylation|NatA complex|ribosome binding|peptide-serine-N-acetyltransferase activity|peptide-glutamate-N-acetyltransferase activity|negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric" NAA15 1383.834522 1167.344376 1600.324667 1.370910504 0.455134391 0.057697587 1 10.0807482 13.58854789 80155 "N-alpha-acetyltransferase 15, NatA auxiliary subunit" "GO:0001525,GO:0003723,GO:0004596,GO:0005515,GO:0005634,GO:0005667,GO:0005737,GO:0005829,GO:0006474,GO:0016020,GO:0016407,GO:0016604,GO:0017196,GO:0030154,GO:0031415,GO:0043022,GO:0043066,GO:0043231,GO:0045893,GO:0050821" "angiogenesis|RNA binding|peptide alpha-N-acetyltransferase activity|protein binding|nucleus|transcription regulator complex|cytoplasm|cytosol|N-terminal protein amino acid acetylation|membrane|acetyltransferase activity|nuclear body|N-terminal peptidyl-methionine acetylation|cell differentiation|NatA complex|ribosome binding|negative regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of transcription, DNA-templated|protein stabilization" NAA16 311.3479055 364.1448589 258.5509522 0.71002225 -0.494063859 0.111917964 1 2.845766855 1.986746488 79612 "N-alpha-acetyltransferase 16, NatA auxiliary subunit" "GO:0004596,GO:0005515,GO:0005634,GO:0005667,GO:0005737,GO:0005829,GO:0006474,GO:0016407,GO:0017196,GO:0031415,GO:0043022,GO:0043066,GO:0045893,GO:0050821,GO:0070062" "peptide alpha-N-acetyltransferase activity|protein binding|nucleus|transcription regulator complex|cytoplasm|cytosol|N-terminal protein amino acid acetylation|acetyltransferase activity|N-terminal peptidyl-methionine acetylation|NatA complex|ribosome binding|negative regulation of apoptotic process|positive regulation of transcription, DNA-templated|protein stabilization|extracellular exosome" NAA20 1626.227647 1411.841639 1840.613656 1.303696962 0.382608561 0.107753506 1 56.52467622 72.45792879 51126 "N-alpha-acetyltransferase 20, NatB catalytic subunit" "GO:0004596,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0017196,GO:0031416" peptide alpha-N-acetyltransferase activity|protein binding|nucleus|cytoplasm|cytosol|N-terminal peptidyl-methionine acetylation|NatB complex NAA25 923.3678199 950.9382887 895.797351 0.942014179 -0.08617932 0.731089361 1 7.825725323 7.248584709 80018 "N-alpha-acetyltransferase 25, NatB auxiliary subunit" "GO:0004596,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0017196,GO:0031416" peptide alpha-N-acetyltransferase activity|protein binding|cytoplasm|Golgi apparatus|cytosol|N-terminal peptidyl-methionine acetylation|NatB complex NAA30 740.0606334 768.8658593 711.2554074 0.925070868 -0.112364204 0.661768364 1 5.399073394 4.910948888 122830 "N-alpha-acetyltransferase 30, NatC catalytic subunit" "GO:0004596,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0017196,GO:0031417" peptide alpha-N-acetyltransferase activity|protein binding|nucleus|cytoplasm|cytosol|polysome|N-terminal peptidyl-methionine acetylation|NatC complex NAA35 1084.657738 1110.121613 1059.193864 0.954124171 -0.067751062 0.784427393 1 8.189818932 7.683345748 60560 "N-alpha-acetyltransferase 35, NatC auxiliary subunit" "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005844,GO:0005886,GO:0006474,GO:0017196,GO:0031417,GO:0043066,GO:0048659" protein binding|nucleoplasm|cytoplasm|cytosol|polysome|plasma membrane|N-terminal protein amino acid acetylation|N-terminal peptidyl-methionine acetylation|NatC complex|negative regulation of apoptotic process|smooth muscle cell proliferation NAA38 501.3341083 469.2266611 533.4415556 1.136852613 0.185045228 0.501048625 1 21.60635418 24.15220764 84316 "N-alpha-acetyltransferase 38, NatC auxiliary subunit" "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005844,GO:0031417,GO:0043066" protein binding|nucleus|nucleoplasm|cytoplasm|polysome|NatC complex|negative regulation of apoptotic process NAA40 1114.503263 1086.192093 1142.814432 1.052129212 0.073311893 0.766326275 1 14.64210045 15.14759342 79829 "N-alpha-acetyltransferase 40, NatD catalytic subunit" "GO:0005515,GO:0005654,GO:0005829,GO:0006474,GO:0006629,GO:0010485,GO:0034451,GO:0043967,GO:0043968,GO:0043998,GO:1990189" protein binding|nucleoplasm|cytosol|N-terminal protein amino acid acetylation|lipid metabolic process|H4 histone acetyltransferase activity|centriolar satellite|histone H4 acetylation|histone H2A acetylation|H2A histone acetyltransferase activity|peptide-serine-N-acetyltransferase activity NAA50 3247.66595 3379.264291 3116.067609 0.922114206 -0.116982652 0.622170792 1 29.50672846 26.75327487 80218 "N-alpha-acetyltransferase 50, NatE catalytic subunit" "GO:0004596,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006474,GO:0007064,GO:0008080,GO:0010485,GO:0016573,GO:0031415,GO:0034087,GO:0043967,GO:0052858,GO:0070062,GO:0071962" "peptide alpha-N-acetyltransferase activity|protein binding|nucleus|cytoplasm|cytosol|N-terminal protein amino acid acetylation|mitotic sister chromatid cohesion|N-acetyltransferase activity|H4 histone acetyltransferase activity|histone acetylation|NatA complex|establishment of mitotic sister chromatid cohesion|histone H4 acetylation|peptidyl-lysine acetyltransferase activity|extracellular exosome|mitotic sister chromatid cohesion, centromeric" NAA60 460.4698889 506.6815608 414.258217 0.817590868 -0.290549013 0.29808988 1 8.256691194 6.637633248 79903 "N-alpha-acetyltransferase 60, NatF catalytic subunit" "GO:0000139,GO:0004402,GO:0004596,GO:0005515,GO:0006334,GO:0006474,GO:0007059,GO:0008283,GO:0010485,GO:0017196,GO:0042803,GO:0043966,GO:0043967" Golgi membrane|histone acetyltransferase activity|peptide alpha-N-acetyltransferase activity|protein binding|nucleosome assembly|N-terminal protein amino acid acetylation|chromosome segregation|cell population proliferation|H4 histone acetyltransferase activity|N-terminal peptidyl-methionine acetylation|protein homodimerization activity|histone H3 acetylation|histone H4 acetylation NAA80 181.3848746 182.0724295 180.6973197 0.992447458 -0.01093737 0.993560128 1 7.150015398 6.977272409 24142 "N-alpha-acetyltransferase 80, NatH catalytic subunit" "GO:0004596,GO:0005737,GO:0005829,GO:0006473,GO:0008064,GO:0008080,GO:0017190,GO:0018002,GO:0030047,GO:1905502" peptide alpha-N-acetyltransferase activity|cytoplasm|cytosol|protein acetylation|regulation of actin polymerization or depolymerization|N-acetyltransferase activity|N-terminal peptidyl-aspartic acid acetylation|N-terminal peptidyl-glutamic acid acetylation|actin modification|acetyl-CoA binding NAAA 350.7898983 377.6702394 323.9095572 0.857651791 -0.221536067 0.463570518 1 4.942512641 4.168021649 27163 N-acylethanolamine acid amidase "GO:0005737,GO:0005764,GO:0006631,GO:0006670,GO:0007269,GO:0008134,GO:0016042,GO:0016810,GO:0017040,GO:0017064,GO:0019898,GO:0043202,GO:0047412,GO:0070062,GO:0070291,GO:0070292,GO:0098793,GO:0102121" "cytoplasm|lysosome|fatty acid metabolic process|sphingosine metabolic process|neurotransmitter secretion|transcription factor binding|lipid catabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|N-acylsphingosine amidohydrolase activity|fatty acid amide hydrolase activity|extrinsic component of membrane|lysosomal lumen|N-(long-chain-acyl)ethanolamine deacylase activity|extracellular exosome|N-acylethanolamine metabolic process|N-acylphosphatidylethanolamine metabolic process|presynapse|ceramidase activity" NAALAD2 191.3631557 166.4662212 216.2600901 1.29912296 0.377537986 0.309326122 1 2.393962887 3.058009642 10003 N-acetylated alpha-linked acidic dipeptidase 2 "GO:0004180,GO:0004181,GO:0005515,GO:0005886,GO:0006508,GO:0008236,GO:0008239,GO:0008652,GO:0016021,GO:0016805,GO:0046872" carboxypeptidase activity|metallocarboxypeptidase activity|protein binding|plasma membrane|proteolysis|serine-type peptidase activity|dipeptidyl-peptidase activity|cellular amino acid biosynthetic process|integral component of membrane|dipeptidase activity|metal ion binding NAALADL2 9.086322201 11.44455271 6.728091692 0.587885946 -0.766391806 0.566347083 1 0.028057088 0.016218357 254827 N-acetylated alpha-linked acidic dipeptidase like 2 "GO:0005515,GO:0005654,GO:0009617,GO:0016021" protein binding|nucleoplasm|response to bacterium|integral component of membrane NAB1 2148.576396 2205.677431 2091.47536 0.948223585 -0.076700818 0.747031987 1 23.3742952 21.79317249 4664 NGFI-A binding protein 1 "GO:0001958,GO:0003712,GO:0005634,GO:0006355,GO:0008134,GO:0014037,GO:0042552,GO:0045682,GO:0045892" "endochondral ossification|transcription coregulator activity|nucleus|regulation of transcription, DNA-templated|transcription factor binding|Schwann cell differentiation|myelination|regulation of epidermis development|negative regulation of transcription, DNA-templated" NAB2 710.7661128 618.0058463 803.5263792 1.300192197 0.378724901 0.138532597 1 13.24039991 16.92699386 4665 NGFI-A binding protein 2 "GO:0001958,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0006355,GO:0008134,GO:0014037,GO:0016480,GO:0042552,GO:0042802,GO:0045682,GO:1902949" "endochondral ossification|transcription coregulator activity|transcription corepressor activity|protein binding|nucleus|regulation of transcription, DNA-templated|transcription factor binding|Schwann cell differentiation|negative regulation of transcription by RNA polymerase III|myelination|identical protein binding|regulation of epidermis development|positive regulation of tau-protein kinase activity" NABP1 982.0077796 1026.888502 937.1270571 0.912588908 -0.131962976 0.594076028 1 30.36185707 27.24423992 64859 nucleic acid binding protein 1 "GO:0000724,GO:0000781,GO:0003677,GO:0003697,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006974,GO:0007093,GO:0010212,GO:0035861,GO:0042795,GO:0044818,GO:0070876" "double-strand break repair via homologous recombination|chromosome, telomeric region|DNA binding|single-stranded DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|DNA repair|cellular response to DNA damage stimulus|mitotic cell cycle checkpoint|response to ionizing radiation|site of double-strand break|snRNA transcription by RNA polymerase II|mitotic G2/M transition checkpoint|SOSS complex" NABP2 964.697526 950.9382887 978.4567632 1.028938234 0.041156381 0.871535119 1 29.55726775 29.90368915 79035 nucleic acid binding protein 2 "GO:0000724,GO:0000781,GO:0003677,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006974,GO:0007093,GO:0010212,GO:0035861,GO:0042795,GO:0044818,GO:0051972,GO:0061730,GO:0070182,GO:0070200,GO:0070876,GO:0098505,GO:1904355" "double-strand break repair via homologous recombination|chromosome, telomeric region|DNA binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|cytosol|DNA repair|cellular response to DNA damage stimulus|mitotic cell cycle checkpoint|response to ionizing radiation|site of double-strand break|snRNA transcription by RNA polymerase II|mitotic G2/M transition checkpoint|regulation of telomerase activity|C-rich strand telomeric DNA binding|DNA polymerase binding|establishment of protein localization to telomere|SOSS complex|G-rich strand telomeric DNA binding|positive regulation of telomere capping" NACA 9934.562837 9703.940283 10165.18539 1.047531734 0.06699395 0.789915817 1 77.13456328 79.44880913 4666 nascent polypeptide associated complex subunit alpha "GO:0003677,GO:0005634,GO:0005737,GO:0005854,GO:0006612,GO:0051082" DNA binding|nucleus|cytoplasm|nascent polypeptide-associated complex|protein targeting to membrane|unfolded protein binding hsa04928 "Parathyroid hormone synthesis, secretion and action" NACA2 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.208479262 0.063124872 342538 nascent polypeptide associated complex subunit alpha 2 "GO:0005634,GO:0005737,GO:0005854,GO:0006612,GO:0051082" nucleus|cytoplasm|nascent polypeptide-associated complex|protein targeting to membrane|unfolded protein binding NACAD 34.19023353 27.05076095 41.32970611 1.52785743 0.611509927 0.386640309 1 0.298213054 0.448002729 23148 NAC alpha domain containing "GO:0005515,GO:0005634,GO:0005737,GO:0005854,GO:0006612,GO:0051082" protein binding|nucleus|cytoplasm|nascent polypeptide-associated complex|protein targeting to membrane|unfolded protein binding NACC1 2008.298545 1979.907619 2036.689471 1.028679041 0.040792916 0.865078001 1 22.24505909 22.50010961 112939 nucleus accumbens associated 1 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0008284,GO:0030054,GO:0042826,GO:0043231,GO:0045892" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|positive regulation of cell population proliferation|cell junction|histone deacetylase binding|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated" NACC2 1349.370073 1423.286191 1275.453954 0.896133161 -0.158214969 0.510915514 1 10.82025187 9.534130616 138151 NACC family member 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005730,GO:0005739,GO:0006357,GO:0008285,GO:0034629,GO:0042803,GO:0042826,GO:0044877,GO:0045892,GO:0051260,GO:1900477,GO:1902231" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleolus|mitochondrion|regulation of transcription by RNA polymerase II|negative regulation of cell population proliferation|cellular protein-containing complex localization|protein homodimerization activity|histone deacetylase binding|protein-containing complex binding|negative regulation of transcription, DNA-templated|protein homooligomerization|negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage" NADK 1209.760883 1227.688382 1191.833385 0.970794709 -0.042761849 0.862935312 1 14.25886236 13.61079385 65220 NAD kinase "GO:0003951,GO:0005515,GO:0005524,GO:0005829,GO:0006741,GO:0016310,GO:0019674,GO:0035774,GO:0046034,GO:0046872" NAD+ kinase activity|protein binding|ATP binding|cytosol|NADP biosynthetic process|phosphorylation|NAD metabolic process|positive regulation of insulin secretion involved in cellular response to glucose stimulus|ATP metabolic process|metal ion binding hsa00760 Nicotinate and nicotinamide metabolism NADK2 443.9025247 475.4691444 412.3359051 0.867219061 -0.205531627 0.46773069 1 5.772273512 4.922059905 133686 "NAD kinase 2, mitochondrial" "GO:0003951,GO:0005524,GO:0005739,GO:0005759,GO:0006741,GO:0016310,GO:0019674,GO:0042803" NAD+ kinase activity|ATP binding|mitochondrion|mitochondrial matrix|NADP biosynthetic process|phosphorylation|NAD metabolic process|protein homodimerization activity hsa00760 Nicotinate and nicotinamide metabolism NADSYN1 796.575106 852.0989699 741.0512421 0.86967743 -0.201447702 0.424867142 1 16.97460094 14.51539809 55191 NAD synthetase 1 "GO:0003952,GO:0004359,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0009435,GO:0019674,GO:0034627" NAD+ synthase (glutamine-hydrolyzing) activity|glutaminase activity|protein binding|ATP binding|cytoplasm|cytosol|NAD biosynthetic process|NAD metabolic process|'de novo' NAD biosynthetic process hsa00760 Nicotinate and nicotinamide metabolism NAE1 1701.652009 1676.106765 1727.197253 1.030481643 0.043318805 0.857542044 1 46.58892578 47.20566663 8883 NEDD8 activating enzyme E1 subunit 1 "GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0018215,GO:0019781,GO:0031625,GO:0032446,GO:0032991,GO:0033314,GO:0042981,GO:0043523,GO:0043687,GO:0045116,GO:0046982,GO:0051402" protein binding|cytoplasm|cytosol|plasma membrane|signal transduction|protein phosphopantetheinylation|NEDD8 activating enzyme activity|ubiquitin protein ligase binding|protein modification by small protein conjugation|protein-containing complex|mitotic DNA replication checkpoint|regulation of apoptotic process|regulation of neuron apoptotic process|post-translational protein modification|protein neddylation|protein heterodimerization activity|neuron apoptotic process hsa05010 Alzheimer disease NAF1 589.5120073 588.8742576 590.149757 1.002165996 0.003121493 0.997975292 1 5.172339832 5.096803527 92345 nuclear assembly factor 1 ribonucleoprotein "GO:0000454,GO:0000493,GO:0003723,GO:0005515,GO:0005654,GO:0005732,GO:0005737,GO:0032212,GO:0042254,GO:0042802,GO:0043489,GO:0051973,GO:0070034,GO:0090669,GO:1904358,GO:1904874,GO:1905323" snoRNA guided rRNA pseudouridine synthesis|box H/ACA snoRNP assembly|RNA binding|protein binding|nucleoplasm|sno(s)RNA-containing ribonucleoprotein complex|cytoplasm|positive regulation of telomere maintenance via telomerase|ribosome biogenesis|identical protein binding|RNA stabilization|positive regulation of telomerase activity|telomerase RNA binding|telomerase RNA stabilization|positive regulation of telomere maintenance via telomere lengthening|positive regulation of telomerase RNA localization to Cajal body|telomerase holoenzyme complex assembly NAGA 1542.095704 1587.671585 1496.519823 0.942587773 -0.085301128 0.72229347 1 22.74050308 21.07623579 4668 alpha-N-acetylgalactosaminidase "GO:0004557,GO:0005737,GO:0005764,GO:0008456,GO:0009311,GO:0016052,GO:0016139,GO:0019377,GO:0042803,GO:0046477,GO:0070062" alpha-galactosidase activity|cytoplasm|lysosome|alpha-N-acetylgalactosaminidase activity|oligosaccharide metabolic process|carbohydrate catabolic process|glycoside catabolic process|glycolipid catabolic process|protein homodimerization activity|glycosylceramide catabolic process|extracellular exosome "hsa00603,hsa04142" Glycosphingolipid biosynthesis - globo and isoglobo series|Lysosome NAGK 659.1756924 638.8141239 679.5372609 1.063748022 0.08915645 0.734771292 1 17.72872372 18.54331672 55577 N-acetylglucosamine kinase "GO:0005515,GO:0005524,GO:0005829,GO:0006044,GO:0006048,GO:0006051,GO:0019262,GO:0045127,GO:0046835,GO:0070062" protein binding|ATP binding|cytosol|N-acetylglucosamine metabolic process|UDP-N-acetylglucosamine biosynthetic process|N-acetylmannosamine metabolic process|N-acetylneuraminate catabolic process|N-acetylglucosamine kinase activity|carbohydrate phosphorylation|extracellular exosome hsa00520 Amino sugar and nucleotide sugar metabolism NAGLU 369.4236134 349.5790646 389.2681622 1.113533966 0.155145565 0.604994393 1 3.735013449 4.089468029 4669 N-acetyl-alpha-glucosaminidase "GO:0004561,GO:0005764,GO:0006027,GO:0007040,GO:0007399,GO:0021680,GO:0042474,GO:0043202,GO:0045475,GO:0046548,GO:0060119,GO:0070062" alpha-N-acetylglucosaminidase activity|lysosome|glycosaminoglycan catabolic process|lysosome organization|nervous system development|cerebellar Purkinje cell layer development|middle ear morphogenesis|lysosomal lumen|locomotor rhythm|retinal rod cell development|inner ear receptor cell development|extracellular exosome "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome NAGPA 158.5599358 175.8299462 141.2899255 0.80356008 -0.315522201 0.431523213 1 4.249873671 3.357882943 51172 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase "GO:0003944,GO:0005515,GO:0005975,GO:0006464,GO:0006486,GO:0006622,GO:0007040,GO:0016021,GO:0032580,GO:0033299" N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity|protein binding|carbohydrate metabolic process|cellular protein modification process|protein glycosylation|protein targeting to lysosome|lysosome organization|integral component of membrane|Golgi cisterna membrane|secretion of lysosomal enzymes hsa04142 Lysosome NAGS 158.3271925 157.1024963 159.5518887 1.015591047 0.022319582 0.973026609 1 3.476066121 3.471187484 162417 N-acetylglutamate synthase "GO:0000050,GO:0003991,GO:0004042,GO:0005739,GO:0005759,GO:0006526,GO:0006536,GO:0016310,GO:0034618,GO:0103045" urea cycle|acetylglutamate kinase activity|acetyl-CoA:L-glutamate N-acetyltransferase activity|mitochondrion|mitochondrial matrix|arginine biosynthetic process|glutamate metabolic process|phosphorylation|arginine binding|methione N-acyltransferase activity hsa00220 Arginine biosynthesis NAIF1 163.5638604 181.0320156 146.0957053 0.807015847 -0.309331092 0.435220567 1 2.843244835 2.256147557 203245 nuclear apoptosis inducing factor 1 "GO:0003674,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0005886,GO:0030308,GO:1902108" molecular_function|protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|plasma membrane|negative regulation of cell growth|regulation of mitochondrial membrane permeability involved in apoptotic process NAIP 18.8513672 28.09117483 9.61155956 0.342155841 -1.547274517 0.079791576 1 0.195868091 0.065895966 4671 NLR family apoptosis inhibitory protein "GO:0005515,GO:0005524,GO:0005737,GO:0006915,GO:0006954,GO:0007399,GO:0016045,GO:0016323,GO:0042742,GO:0043027,GO:0043066,GO:0043154,GO:0043524,GO:0045087,GO:0046872,GO:0070269,GO:0072557" protein binding|ATP binding|cytoplasm|apoptotic process|inflammatory response|nervous system development|detection of bacterium|basolateral plasma membrane|defense response to bacterium|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of neuron apoptotic process|innate immune response|metal ion binding|pyroptosis|IPAF inflammasome complex "hsa04621,hsa05130,hsa05131,hsa05132,hsa05134" NOD-like receptor signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Legionellosis NALCN 339.4296339 344.3769952 334.4822727 0.97126776 -0.042059021 0.899460765 1 2.336184987 2.231091494 259232 "sodium leak channel, non-selective" "GO:0005244,GO:0005261,GO:0005272,GO:0005515,GO:0005886,GO:0016021,GO:0022840,GO:0034220,GO:0034765,GO:0035725,GO:0060075,GO:0070588,GO:0071805" voltage-gated ion channel activity|cation channel activity|sodium channel activity|protein binding|plasma membrane|integral component of membrane|leak channel activity|ion transmembrane transport|regulation of ion transmembrane transport|sodium ion transmembrane transport|regulation of resting membrane potential|calcium ion transmembrane transport|potassium ion transmembrane transport NAMPT 19468.51553 19627.4079 19309.62316 0.983809134 -0.023549646 0.931195157 1 240.247405 232.4024671 10135 nicotinamide phosphoribosyltransferase "GO:0004514,GO:0005125,GO:0005515,GO:0005829,GO:0007165,GO:0007267,GO:0007623,GO:0008284,GO:0008286,GO:0016607,GO:0030054,GO:0032922,GO:0034356,GO:0042802,GO:0045944,GO:0047280,GO:0051770,GO:0060612,GO:0070062" nicotinate-nucleotide diphosphorylase (carboxylating) activity|cytokine activity|protein binding|cytosol|signal transduction|cell-cell signaling|circadian rhythm|positive regulation of cell population proliferation|insulin receptor signaling pathway|nuclear speck|cell junction|circadian regulation of gene expression|NAD biosynthesis via nicotinamide riboside salvage pathway|identical protein binding|positive regulation of transcription by RNA polymerase II|nicotinamide phosphoribosyltransferase activity|positive regulation of nitric-oxide synthase biosynthetic process|adipose tissue development|extracellular exosome "hsa00760,hsa04621" Nicotinate and nicotinamide metabolism|NOD-like receptor signaling pathway NANOS1 17.69206642 22.88910542 12.49502743 0.545894092 -0.87330701 0.340205819 1 0.304094968 0.163225801 340719 nanos C2HC-type zinc finger 1 "GO:0001558,GO:0001894,GO:0003729,GO:0005515,GO:0005737,GO:0008270,GO:0010608,GO:0010631,GO:0016477,GO:0017148,GO:0030371,GO:0048471,GO:0048477,GO:0098749,GO:1900153" "regulation of cell growth|tissue homeostasis|mRNA binding|protein binding|cytoplasm|zinc ion binding|posttranscriptional regulation of gene expression|epithelial cell migration|cell migration|negative regulation of translation|translation repressor activity|perinuclear region of cytoplasm|oogenesis|cerebellar neuron development|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" NANOS3 4.885037707 2.080827765 7.689247648 3.695283087 1.88568489 0.299624042 1 0.117141301 0.425626771 342977 nanos C2HC-type zinc finger 3 "GO:0000932,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0006417,GO:0007275,GO:0007281,GO:0007283,GO:0008270,GO:0010494,GO:0017148,GO:0048471,GO:0048477,GO:0051726,GO:1900153,GO:2001234" "P-body|RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|regulation of translation|multicellular organism development|germ cell development|spermatogenesis|zinc ion binding|cytoplasmic stress granule|negative regulation of translation|perinuclear region of cytoplasm|oogenesis|regulation of cell cycle|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of apoptotic signaling pathway" NANP 436.5057711 445.2971418 427.7144004 0.960514587 -0.05812057 0.844570654 1 6.248932431 5.901752222 140838 N-acetylneuraminic acid phosphatase "GO:0005575,GO:0005829,GO:0005975,GO:0006045,GO:0016311,GO:0046380,GO:0050124" cellular_component|cytosol|carbohydrate metabolic process|N-acetylglucosamine biosynthetic process|dephosphorylation|N-acetylneuraminate biosynthetic process|N-acylneuraminate-9-phosphatase activity hsa00520 Amino sugar and nucleotide sugar metabolism NANS 2359.620554 2030.887899 2688.353209 1.32373294 0.404612091 0.087081621 1 73.0847974 95.12586129 54187 N-acetylneuraminate synthase "GO:0005737,GO:0005829,GO:0006055,GO:0008781,GO:0016051,GO:0047444,GO:0050462,GO:0070062,GO:0070085" cytoplasm|cytosol|CMP-N-acetylneuraminate biosynthetic process|N-acylneuraminate cytidylyltransferase activity|carbohydrate biosynthetic process|N-acylneuraminate-9-phosphate synthase activity|N-acetylneuraminate synthase activity|extracellular exosome|glycosylation hsa00520 Amino sugar and nucleotide sugar metabolism NAP1L1 17953.5675 18449.65938 17457.47563 0.94622211 -0.079749223 0.766891622 1 68.26292375 63.51102998 4673 nucleosome assembly protein 1 like 1 "GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0006260,GO:0006334,GO:0008284,GO:0016020,GO:0030154,GO:0042393,GO:0042470,GO:0050769,GO:2000179" chromatin binding|RNA binding|protein binding|nucleus|cytoplasm|DNA replication|nucleosome assembly|positive regulation of cell population proliferation|membrane|cell differentiation|histone binding|melanosome|positive regulation of neurogenesis|positive regulation of neural precursor cell proliferation NAP1L3 119.4601269 108.2030438 130.71721 1.208073317 0.272708013 0.544131972 1 2.179916036 2.589430367 4675 nucleosome assembly protein 1 like 3 "GO:0003682,GO:0005515,GO:0005634,GO:0006334,GO:0030154,GO:0042393" chromatin binding|protein binding|nucleus|nucleosome assembly|cell differentiation|histone binding NAP1L4 3338.849276 2997.432396 3680.266155 1.227806225 0.29608289 0.211894778 1 46.10013197 55.65487071 4676 nucleosome assembly protein 1 like 4 "GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0006334,GO:0030154,GO:0031491,GO:0042393,GO:0051082" chromatin binding|RNA binding|protein binding|nucleus|cytoplasm|nucleosome assembly|cell differentiation|nucleosome binding|histone binding|unfolded protein binding NAP1L5 17.29074637 24.96993318 9.61155956 0.384925322 -1.377349516 0.131316287 1 0.695148378 0.263102621 266812 nucleosome assembly protein 1 like 5 "GO:0003682,GO:0005515,GO:0005634,GO:0006334,GO:0042393" chromatin binding|protein binding|nucleus|nucleosome assembly|histone binding NAPA 981.0422076 938.4533221 1023.631093 1.090763993 0.125338982 0.613035493 1 28.58648915 30.65933936 8775 NSF attachment protein alpha "GO:0000139,GO:0000149,GO:0005483,GO:0005515,GO:0005774,GO:0005829,GO:0005886,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0007420,GO:0010807,GO:0016020,GO:0016082,GO:0019905,GO:0030182,GO:0031201,GO:0032781,GO:0035249,GO:0035494,GO:0044877,GO:0045176,GO:0048208,GO:0061025,GO:0070044,GO:0070062,GO:0098793,GO:0098794,GO:0098978" "Golgi membrane|SNARE binding|soluble NSF attachment protein activity|protein binding|vacuolar membrane|cytosol|plasma membrane|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|brain development|regulation of synaptic vesicle priming|membrane|synaptic vesicle priming|syntaxin binding|neuron differentiation|SNARE complex|positive regulation of ATPase activity|synaptic transmission, glutamatergic|SNARE complex disassembly|protein-containing complex binding|apical protein localization|COPII vesicle coating|membrane fusion|synaptobrevin 2-SNAP-25-syntaxin-1a complex|extracellular exosome|presynapse|postsynapse|glutamatergic synapse" hsa04721 Synaptic vesicle cycle NAPB 426.5180436 384.9531366 468.0829506 1.215947881 0.282081392 0.322425229 1 4.961178794 5.931588539 63908 NSF attachment protein beta "GO:0005483,GO:0005515,GO:0005774,GO:0006886,GO:0010807,GO:0019905,GO:0031201,GO:0035249,GO:0035494,GO:0045202,GO:0070044,GO:0070062" "soluble NSF attachment protein activity|protein binding|vacuolar membrane|intracellular protein transport|regulation of synaptic vesicle priming|syntaxin binding|SNARE complex|synaptic transmission, glutamatergic|SNARE complex disassembly|synapse|synaptobrevin 2-SNAP-25-syntaxin-1a complex|extracellular exosome" NAPEPLD 69.12838694 86.35435226 51.90242162 0.60104002 -0.734467039 0.168688833 1 0.575999633 0.340405663 222236 N-acyl phosphatidylethanolamine phospholipase D "GO:0000139,GO:0001523,GO:0001659,GO:0005635,GO:0005654,GO:0005737,GO:0005769,GO:0005794,GO:0007568,GO:0008270,GO:0009395,GO:0031901,GO:0032052,GO:0035900,GO:0042622,GO:0042802,GO:0043227,GO:0048874,GO:0050729,GO:0070062,GO:0070290,GO:0070291,GO:0070292,GO:0090336,GO:0102200,GO:1903999" Golgi membrane|retinoid metabolic process|temperature homeostasis|nuclear envelope|nucleoplasm|cytoplasm|early endosome|Golgi apparatus|aging|zinc ion binding|phospholipid catabolic process|early endosome membrane|bile acid binding|response to isolation stress|photoreceptor outer segment membrane|identical protein binding|membrane-bounded organelle|host-mediated regulation of intestinal microbiota composition|positive regulation of inflammatory response|extracellular exosome|N-acylphosphatidylethanolamine-specific phospholipase D activity|N-acylethanolamine metabolic process|N-acylphosphatidylethanolamine metabolic process|positive regulation of brown fat cell differentiation|N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity|negative regulation of eating behavior hsa04723 Retrograde endocannabinoid signaling NAPG 1074.462419 968.6253247 1180.299514 1.218530513 0.285142378 0.243364436 1 12.96557645 15.53457649 8774 NSF attachment protein gamma "GO:0005483,GO:0005515,GO:0005739,GO:0005765,GO:0005774,GO:0006886,GO:0006891,GO:0019905,GO:0031201,GO:0045202,GO:0050821,GO:0061025,GO:0065003,GO:0070062" soluble NSF attachment protein activity|protein binding|mitochondrion|lysosomal membrane|vacuolar membrane|intracellular protein transport|intra-Golgi vesicle-mediated transport|syntaxin binding|SNARE complex|synapse|protein stabilization|membrane fusion|protein-containing complex assembly|extracellular exosome NAPRT 756.1625108 762.623376 749.7016457 0.98305621 -0.024654184 0.927982672 1 20.69131059 20.00034695 93100 nicotinate phosphoribosyltransferase "GO:0004514,GO:0004516,GO:0005515,GO:0005576,GO:0005829,GO:0006979,GO:0034355,GO:0034356,GO:0035578,GO:0043312,GO:0046872,GO:0070062" nicotinate-nucleotide diphosphorylase (carboxylating) activity|nicotinate phosphoribosyltransferase activity|protein binding|extracellular region|cytosol|response to oxidative stress|NAD salvage|NAD biosynthesis via nicotinamide riboside salvage pathway|azurophil granule lumen|neutrophil degranulation|metal ion binding|extracellular exosome hsa00760 Nicotinate and nicotinamide metabolism NAPSA 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.036338336 0.132033436 9476 napsin A aspartic peptidase "GO:0004175,GO:0004190,GO:0005515,GO:0005615,GO:0005764,GO:0006508,GO:0008233,GO:0033619,GO:0043129,GO:0044267,GO:0070062,GO:0097208,GO:0097486" endopeptidase activity|aspartic-type endopeptidase activity|protein binding|extracellular space|lysosome|proteolysis|peptidase activity|membrane protein proteolysis|surfactant homeostasis|cellular protein metabolic process|extracellular exosome|alveolar lamellar body|multivesicular body lumen hsa04142 Lysosome NARF 780.8651021 780.310412 781.4197922 1.001421717 0.002049647 0.999381203 1 13.52947776 13.32199348 26502 nuclear prelamin A recognition factor "GO:0005521,GO:0005638,GO:0005652,GO:0005654,GO:0005730,GO:0031981" lamin binding|lamin filament|nuclear lamina|nucleoplasm|nucleolus|nuclear lumen NARS1 4883.146653 5084.502644 4681.790662 0.92079619 -0.119046231 0.619910085 1 100.5374439 91.0253865 4677 asparaginyl-tRNA synthetase 1 "GO:0003676,GO:0004816,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006418,GO:0006421,GO:0016477,GO:0031728,GO:0046983,GO:0070062" nucleic acid binding|asparagine-tRNA ligase activity|protein binding|ATP binding|cytoplasm|cytosol|tRNA aminoacylation for protein translation|asparaginyl-tRNA aminoacylation|cell migration|CCR3 chemokine receptor binding|protein dimerization activity|extracellular exosome hsa00970 Aminoacyl-tRNA biosynthesis NARS2 563.9029803 534.7727357 593.0332248 1.108944389 0.14918702 0.578652474 1 11.01924248 12.01524654 79731 "asparaginyl-tRNA synthetase 2, mitochondrial" "GO:0003676,GO:0004816,GO:0005524,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0006421" nucleic acid binding|asparagine-tRNA ligase activity|ATP binding|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|asparaginyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis NASP 3506.781154 3469.780299 3543.78201 1.021327492 0.030445545 0.899101262 1 56.14790702 56.38580343 4678 nuclear autoantigenic sperm protein "GO:0000082,GO:0000785,GO:0001824,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006260,GO:0006335,GO:0006336,GO:0008584,GO:0015031,GO:0032991,GO:0033574,GO:0034080,GO:0042393,GO:0043486" G1/S transition of mitotic cell cycle|chromatin|blastocyst development|protein binding|nucleus|nucleoplasm|cytoplasm|DNA replication|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|male gonad development|protein transport|protein-containing complex|response to testosterone|CENP-A containing nucleosome assembly|histone binding|histone exchange NAT1 79.50295764 81.15228285 77.85363244 0.95935234 -0.059867326 0.932181304 1 0.997684447 0.941114619 9 N-acetyltransferase 1 "GO:0004060,GO:0005829,GO:0006805" arylamine N-acetyltransferase activity|cytosol|xenobiotic metabolic process "hsa00232,hsa00983,hsa05204" Caffeine metabolism|Drug metabolism - other enzymes|Chemical carcinogenesis NAT10 1427.411175 1554.378341 1300.444008 0.836632868 -0.257333419 0.282270493 1 20.87951553 17.17617745 55226 N-acetyltransferase 10 "GO:0000049,GO:0000154,GO:0000781,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005697,GO:0005730,GO:0006473,GO:0008080,GO:0010824,GO:0016020,GO:0030496,GO:0032211,GO:0045727,GO:0051391,GO:0070182,GO:0106162,GO:1904812,GO:1990883" "tRNA binding|rRNA modification|chromosome, telomeric region|RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|telomerase holoenzyme complex|nucleolus|protein acetylation|N-acetyltransferase activity|regulation of centrosome duplication|membrane|midbody|negative regulation of telomere maintenance via telomerase|positive regulation of translation|tRNA acetylation|DNA polymerase binding|mRNA N-acetyltransferase activity|rRNA acetylation involved in maturation of SSU-rRNA|rRNA cytidine N-acetyltransferase activity" hsa03008 Ribosome biogenesis in eukaryotes NAT14 277.4702877 256.982229 297.9583464 1.159451171 0.213442064 0.51441319 1 10.15901426 11.58177736 57106 N-acetyltransferase 14 (putative) "GO:0003677,GO:0005634,GO:0006352,GO:0008080,GO:0016021,GO:0045893" "DNA binding|nucleus|DNA-templated transcription, initiation|N-acetyltransferase activity|integral component of membrane|positive regulation of transcription, DNA-templated" NAT16 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.014850221 0.040468124 375607 N-acetyltransferase 16 (putative) "GO:0008080,GO:0016747" "N-acetyltransferase activity|transferase activity, transferring acyl groups other than amino-acyl groups" NAT8L 104.9188703 117.5667687 92.27097178 0.784838886 -0.349531572 0.453865366 1 1.036050589 0.799526114 339983 N-acetyltransferase 8 like "GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0008080,GO:0008652,GO:0016021,GO:0017188,GO:0030867,GO:0031966" protein binding|cytoplasm|mitochondrion|mitochondrial matrix|N-acetyltransferase activity|cellular amino acid biosynthetic process|integral component of membrane|aspartate N-acetyltransferase activity|rough endoplasmic reticulum membrane|mitochondrial membrane hsa00250 "Alanine, aspartate and glutamate metabolism" NAT9 1067.129218 1078.909196 1055.34924 0.97816317 -0.03185295 0.900161089 1 21.41294193 20.59485908 26151 N-acetyltransferase 9 (putative) "GO:0005515,GO:0006473,GO:0008080,GO:0032991" protein binding|protein acetylation|N-acetyltransferase activity|protein-containing complex NATD1 532.3383192 551.4193578 513.2572805 0.930793004 -0.103467728 0.70594464 1 5.968006015 5.462023208 256302 N-acetyltransferase domain containing 1 GO:0005515 protein binding NAV1 2156.892219 2638.489606 1675.294831 0.634944639 -0.655297286 0.005696099 0.458200904 10.00933615 6.249025748 89796 neuron navigator 1 "GO:0001578,GO:0001764,GO:0005737,GO:0005874,GO:0007399,GO:0015630,GO:0043194" microtubule bundle formation|neuron migration|cytoplasm|microtubule|nervous system development|microtubule cytoskeleton|axon initial segment NAV2 2591.415198 2438.730141 2744.100254 1.125216853 0.170203066 0.471986946 1 5.778818285 6.39361447 89797 neuron navigator 2 "GO:0005515,GO:0005524,GO:0005654,GO:0007399,GO:0022008,GO:0032508,GO:0043138" protein binding|ATP binding|nucleoplasm|nervous system development|neurogenesis|DNA duplex unwinding|3'-5' DNA helicase activity NAV3 2263.832051 2014.241277 2513.422825 1.247826094 0.319416884 0.176686597 1 5.448094619 6.684514709 89795 neuron navigator 3 "GO:0005524,GO:0005640,GO:0007026,GO:0007399,GO:0008017,GO:0016887,GO:0022008,GO:0030336,GO:0031116,GO:0032703,GO:1990752" ATP binding|nuclear outer membrane|negative regulation of microtubule depolymerization|nervous system development|microtubule binding|ATPase activity|neurogenesis|negative regulation of cell migration|positive regulation of microtubule polymerization|negative regulation of interleukin-2 production|microtubule end NAXD 1007.176472 981.1102913 1033.242653 1.053136087 0.074691874 0.764306103 1 18.84811125 19.51746951 55739 NAD(P)HX dehydratase "GO:0005515,GO:0005524,GO:0005575,GO:0005759,GO:0008150,GO:0034356,GO:0047453,GO:0052855,GO:0110051" protein binding|ATP binding|cellular_component|mitochondrial matrix|biological_process|NAD biosynthesis via nicotinamide riboside salvage pathway|ATP-dependent NAD(P)H-hydrate dehydratase activity|ADP-dependent NAD(P)H-hydrate dehydratase activity|metabolite repair NAXE 1240.22035 1270.345351 1210.095349 0.952571951 -0.070100027 0.774253784 1 16.05398924 15.03667923 128240 NAD(P)HX epimerase "GO:0000166,GO:0002040,GO:0005515,GO:0005576,GO:0005615,GO:0005739,GO:0005759,GO:0006869,GO:0010874,GO:0016020,GO:0016525,GO:0031580,GO:0034356,GO:0046496,GO:0046872,GO:0052856,GO:0052857,GO:0070062" nucleotide binding|sprouting angiogenesis|protein binding|extracellular region|extracellular space|mitochondrion|mitochondrial matrix|lipid transport|regulation of cholesterol efflux|membrane|negative regulation of angiogenesis|membrane raft distribution|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinamide nucleotide metabolic process|metal ion binding|NADHX epimerase activity|NADPHX epimerase activity|extracellular exosome NBAS 1337.945641 1350.45722 1325.434063 0.981470604 -0.026983036 0.913725235 1 9.321187245 8.995384 51594 NBAS subunit of NRZ tethering complex "GO:0000149,GO:0000956,GO:0005783,GO:0005789,GO:0005829,GO:0006890,GO:0015031,GO:0016020,GO:0070939,GO:2000623" "SNARE binding|nuclear-transcribed mRNA catabolic process|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|protein transport|membrane|Dsl1/NZR complex|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" NBDY 1113.646517 1025.848088 1201.444945 1.171172378 0.227953433 0.34993488 1 23.34653605 26.88527311 550643 negative regulator of P-body association "GO:0000932,GO:0000956,GO:0005515,GO:0006397,GO:0010607" P-body|nuclear-transcribed mRNA catabolic process|protein binding|mRNA processing|negative regulation of cytoplasmic mRNA processing body assembly NBEA 452.0075693 536.8535634 367.1615752 0.683913827 -0.548113537 0.050171368 1 2.146938028 1.443750247 26960 neurobeachin "GO:0005802,GO:0005829,GO:0005886,GO:0008104,GO:0012505,GO:0016020,GO:0019901" trans-Golgi network|cytosol|plasma membrane|protein localization|endomembrane system|membrane|protein kinase binding NBEAL1 1449.65677 1507.559716 1391.753824 0.923183214 -0.115311102 0.631093318 1 4.376635547 3.97282524 65065 neurobeachin like 1 "GO:0005829,GO:0008104,GO:0016020,GO:0019901" cytosol|protein localization|membrane|protein kinase binding NBEAL2 664.3029199 735.572615 593.0332248 0.806219825 -0.310754836 0.229118542 1 3.78153921 2.997735146 23218 neurobeachin like 2 "GO:0005515,GO:0005783,GO:0005829,GO:0005886,GO:0008104,GO:0016020,GO:0019901,GO:0030220,GO:0043312,GO:0070821,GO:0101003" protein binding|endoplasmic reticulum|cytosol|plasma membrane|protein localization|membrane|protein kinase binding|platelet formation|neutrophil degranulation|tertiary granule membrane|ficolin-1-rich granule membrane NBL1 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.071185868 0.032331264 4681 "NBL1, DAN family BMP antagonist" "GO:0005515,GO:0005615,GO:0007165,GO:0007399,GO:0009887,GO:0016015,GO:0030514,GO:0035582,GO:0036122,GO:0038098,GO:0042802,GO:0045666,GO:0048018,GO:0048263,GO:0048812,GO:0090027" protein binding|extracellular space|signal transduction|nervous system development|animal organ morphogenesis|morphogen activity|negative regulation of BMP signaling pathway|sequestering of BMP in extracellular matrix|BMP binding|sequestering of BMP from receptor via BMP binding|identical protein binding|positive regulation of neuron differentiation|receptor ligand activity|determination of dorsal identity|neuron projection morphogenesis|negative regulation of monocyte chemotaxis hsa04350 TGF-beta signaling pathway NBN 1953.592528 1881.0683 2026.116755 1.077109617 0.107165079 0.651947563 1 19.55759944 20.71317283 4683 nibrin "GO:0000077,GO:0000723,GO:0000724,GO:0000729,GO:0000781,GO:0001832,GO:0003684,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0005730,GO:0005829,GO:0006260,GO:0006302,GO:0006303,GO:0007050,GO:0007095,GO:0008134,GO:0008283,GO:0016032,GO:0016605,GO:0030174,GO:0030330,GO:0030870,GO:0031860,GO:0031954,GO:0032206,GO:0032508,GO:0033674,GO:0035861,GO:0042405,GO:0042770,GO:0045190,GO:0047485,GO:0050885,GO:0051321,GO:0090656,GO:0090737,GO:0097193,GO:1901796,GO:1904354" "DNA damage checkpoint|telomere maintenance|double-strand break repair via homologous recombination|DNA double-strand break processing|chromosome, telomeric region|blastocyst growth|damaged DNA binding|protein binding|nucleus|nucleoplasm|replication fork|nucleolus|cytosol|DNA replication|double-strand break repair|double-strand break repair via nonhomologous end joining|cell cycle arrest|mitotic G2 DNA damage checkpoint|transcription factor binding|cell population proliferation|viral process|PML body|regulation of DNA-dependent DNA replication initiation|DNA damage response, signal transduction by p53 class mediator|Mre11 complex|telomeric 3' overhang formation|positive regulation of protein autophosphorylation|positive regulation of telomere maintenance|DNA duplex unwinding|positive regulation of kinase activity|site of double-strand break|nuclear inclusion body|signal transduction in response to DNA damage|isotype switching|protein N-terminus binding|neuromuscular process controlling balance|meiotic cell cycle|t-circle formation|telomere maintenance via telomere trimming|intrinsic apoptotic signaling pathway|regulation of signal transduction by p53 class mediator|negative regulation of telomere capping" "hsa03440,hsa04218" Homologous recombination|Cellular senescence NBPF1 161.9585802 189.3553266 134.5618338 0.710631363 -0.492826733 0.211557996 1 1.697270031 1.185950307 55672 NBPF member 1 "GO:0005515,GO:0005737" protein binding|cytoplasm NBPF10 226.7422581 224.7293987 228.7551175 1.017913628 0.025615151 0.955067997 1 0.919597836 0.920407286 100132406 NBPF member 10 "GO:0003723,GO:0005737" RNA binding|cytoplasm NBPF11 249.705591 285.0734038 214.3377782 0.75186873 -0.411447293 0.219944322 1 2.503512197 1.850814586 200030 NBPF member 11 GO:0005737 cytoplasm NBPF12 267.0906866 274.669265 259.5121081 0.944816698 -0.081893632 0.812703052 1 1.977684006 1.837281238 149013 NBPF member 12 GO:0005737 cytoplasm NBPF14 809.9124025 848.9777282 770.8470767 0.907970906 -0.139282025 0.58175581 1 4.494879068 4.012925737 25832 NBPF member 14 GO:0005737 cytoplasm NBPF15 2372.33139 2389.830688 2354.832092 0.985355198 -0.021284217 0.930088311 1 21.54770595 20.87685289 284565 NBPF member 15 GO:0005737 cytoplasm NBPF19 806.6722739 839.6140033 773.7305446 0.921531253 -0.117895 0.641980715 1 3.214163705 2.912388046 101060226 NBPF member 19 GO:0005737 cytoplasm NBPF20 266.0502727 272.5884373 259.5121081 0.95202904 -0.070922514 0.839412427 1 0.788484764 0.738099108 100288142 NBPF member 20 GO:0005737 cytoplasm NBPF26 131.8608052 143.5771158 120.1444945 0.836794177 -0.257055282 0.553494138 1 1.351878403 1.11231414 101060684 NBPF member 26 GO:0005737 cytoplasm NBPF3 282.7119861 268.4267817 296.9971904 1.106436506 0.145920663 0.65735781 1 2.763928997 3.00693858 84224 NBPF member 3 GO:0005737 cytoplasm NBPF8 901.142346 947.8170471 854.4676449 0.901511159 -0.149582745 0.548818318 1 6.96355366 6.172672168 728841 NBPF member 8 GO:0005737 cytoplasm NBPF9 1561.883075 1678.187593 1445.578558 0.86139271 -0.215256981 0.366536772 1 10.30156285 8.725201936 400818 NBPF member 9 GO:0005737 cytoplasm NBR1 5608.254034 5990.703136 5225.804933 0.872319127 -0.197072071 0.414199225 1 49.23203202 42.22739934 4077 NBR1 autophagy cargo receptor "GO:0000407,GO:0005515,GO:0005654,GO:0005739,GO:0005758,GO:0005764,GO:0005770,GO:0005776,GO:0005829,GO:0008270,GO:0016020,GO:0016236,GO:0016604,GO:0030500,GO:0031430,GO:0032872,GO:0043130,GO:0043231,GO:0043235,GO:0045668,GO:0051019" phagophore assembly site|protein binding|nucleoplasm|mitochondrion|mitochondrial intermembrane space|lysosome|late endosome|autophagosome|cytosol|zinc ion binding|membrane|macroautophagy|nuclear body|regulation of bone mineralization|M band|regulation of stress-activated MAPK cascade|ubiquitin binding|intracellular membrane-bounded organelle|receptor complex|negative regulation of osteoblast differentiation|mitogen-activated protein kinase binding hsa04137 Mitophagy - animal NCAPD2 8111.686406 8819.588483 7403.784329 0.839470497 -0.252448472 0.306735386 1 97.55134251 80.52113109 9918 non-SMC condensin I complex subunit D2 "GO:0000228,GO:0000779,GO:0000793,GO:0000796,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007076,GO:0010032,GO:0016020,GO:0042393,GO:0051301,GO:0051304" "nuclear chromosome|condensed chromosome, centromeric region|condensed chromosome|condensin complex|chromatin binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|mitotic chromosome condensation|meiotic chromosome condensation|membrane|histone binding|cell division|chromosome separation" NCAPD3 2949.359045 2852.814866 3045.903225 1.067683452 0.094483979 0.690584857 1 19.43197015 20.4000168 23310 non-SMC condensin II complex subunit D3 "GO:0000779,GO:0000796,GO:0003682,GO:0005515,GO:0005654,GO:0005721,GO:0007076,GO:0010032,GO:0016020,GO:0035064,GO:0042393,GO:0051301,GO:0051304" "condensed chromosome, centromeric region|condensin complex|chromatin binding|protein binding|nucleoplasm|pericentric heterochromatin|mitotic chromosome condensation|meiotic chromosome condensation|membrane|methylated histone binding|histone binding|cell division|chromosome separation" NCAPG 2913.399985 2842.410727 2984.389243 1.049950035 0.070320675 0.767409112 1 39.25834275 40.52954922 64151 non-SMC condensin I complex subunit G "GO:0000779,GO:0000793,GO:0000796,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007076,GO:0016020,GO:0051301" "condensed chromosome, centromeric region|condensed chromosome|condensin complex|protein binding|nucleus|cytoplasm|cytosol|mitotic chromosome condensation|membrane|cell division" NCAPG2 3760.579818 3635.206106 3885.95353 1.068977499 0.096231485 0.686265184 1 32.46933367 34.12817919 54892 non-SMC condensin II complex subunit G2 "GO:0000070,GO:0000796,GO:0001833,GO:0005515,GO:0005634,GO:0005654,GO:0006366,GO:0010468,GO:0016020,GO:0016607,GO:0030218,GO:0030261,GO:0035064,GO:0043425,GO:0045647,GO:0051301,GO:0061098,GO:0140416,GO:2000273" mitotic sister chromatid segregation|condensin complex|inner cell mass cell proliferation|protein binding|nucleus|nucleoplasm|transcription by RNA polymerase II|regulation of gene expression|membrane|nuclear speck|erythrocyte differentiation|chromosome condensation|methylated histone binding|bHLH transcription factor binding|negative regulation of erythrocyte differentiation|cell division|positive regulation of protein tyrosine kinase activity|transcription regulator inhibitor activity|positive regulation of signaling receptor activity NCAPH 1737.035527 1822.805122 1651.265932 0.905892743 -0.142587848 0.548878053 1 34.87979893 31.06861775 23397 non-SMC condensin I complex subunit H "GO:0000796,GO:0003682,GO:0005515,GO:0005654,GO:0005829,GO:0007076,GO:0016020,GO:0044547,GO:0051301,GO:0072587,GO:2000373" "condensin complex|chromatin binding|protein binding|nucleoplasm|cytosol|mitotic chromosome condensation|membrane|DNA topoisomerase binding|cell division|DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity" NCAPH2 1119.120958 1056.020091 1182.221826 1.119506945 0.162863478 0.504907418 1 26.86265556 29.56969972 29781 non-SMC condensin II complex subunit H2 "GO:0000793,GO:0000796,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0007076,GO:0010032,GO:0016020,GO:0030054,GO:0033077,GO:0045171,GO:0051306,GO:0051309" condensed chromosome|condensin complex|chromatin binding|protein binding|nucleus|nucleoplasm|mitotic chromosome condensation|meiotic chromosome condensation|membrane|cell junction|T cell differentiation in thymus|intercellular bridge|mitotic sister chromatid separation|female meiosis chromosome separation NCBP1 1809.498392 1883.149128 1735.847657 0.921779179 -0.117506914 0.621283766 1 20.16861486 18.27991388 4686 nuclear cap binding protein subunit 1 "GO:0000184,GO:0000245,GO:0000339,GO:0000340,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0005845,GO:0005846,GO:0006366,GO:0006368,GO:0006369,GO:0006370,GO:0006401,GO:0006405,GO:0006406,GO:0006446,GO:0008334,GO:0008380,GO:0008543,GO:0016070,GO:0030307,GO:0031047,GO:0031124,GO:0031442,GO:0034518,GO:0042795,GO:0045292,GO:0048026,GO:0050684,GO:0051168,GO:0098789,GO:1900363,GO:1905216,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|spliceosomal complex assembly|RNA cap binding|RNA 7-methylguanosine cap binding|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|mRNA cap binding complex|nuclear cap binding complex|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|termination of RNA polymerase II transcription|7-methylguanosine mRNA capping|RNA catabolic process|RNA export from nucleus|mRNA export from nucleus|regulation of translational initiation|histone mRNA metabolic process|RNA splicing|fibroblast growth factor receptor signaling pathway|RNA metabolic process|positive regulation of cell growth|gene silencing by RNA|mRNA 3'-end processing|positive regulation of mRNA 3'-end processing|RNA cap binding complex|snRNA transcription by RNA polymerase II|mRNA cis splicing, via spliceosome|positive regulation of mRNA splicing, via spliceosome|regulation of mRNA processing|nuclear export|pre-mRNA cleavage required for polyadenylation|regulation of mRNA polyadenylation|positive regulation of RNA binding|ribonucleoprotein complex" "hsa03013,hsa03015,hsa03040,hsa05014" RNA transport|mRNA surveillance pathway|Spliceosome|Amyotrophic lateral sclerosis NCBP2 1983.422346 1995.513827 1971.330866 0.987881336 -0.017590338 0.943001174 1 19.47995342 18.9218621 22916 nuclear cap binding protein subunit 2 "GO:0000184,GO:0000339,GO:0000340,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005845,GO:0005846,GO:0006366,GO:0006368,GO:0006369,GO:0006370,GO:0006405,GO:0006406,GO:0006408,GO:0006446,GO:0008334,GO:0008380,GO:0008543,GO:0016070,GO:0017069,GO:0031047,GO:0031124,GO:0031442,GO:0034518,GO:0042795,GO:0045292,GO:0046833,GO:0051168,GO:0098789,GO:1900363" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA cap binding|RNA 7-methylguanosine cap binding|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|mRNA cap binding complex|nuclear cap binding complex|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|termination of RNA polymerase II transcription|7-methylguanosine mRNA capping|RNA export from nucleus|mRNA export from nucleus|snRNA export from nucleus|regulation of translational initiation|histone mRNA metabolic process|RNA splicing|fibroblast growth factor receptor signaling pathway|RNA metabolic process|snRNA binding|gene silencing by RNA|mRNA 3'-end processing|positive regulation of mRNA 3'-end processing|RNA cap binding complex|snRNA transcription by RNA polymerase II|mRNA cis splicing, via spliceosome|positive regulation of RNA export from nucleus|nuclear export|pre-mRNA cleavage required for polyadenylation|regulation of mRNA polyadenylation" "hsa03013,hsa03015,hsa03040" RNA transport|mRNA surveillance pathway|Spliceosome NCBP2AS2 220.5394038 213.2848459 227.7939616 1.068026941 0.094948039 0.797620101 1 13.08347153 13.73967247 152217 NCBP2 antisense 2 (head to head) GO:0005515 protein binding NCBP3 1401.524745 1492.993922 1310.055568 0.877468789 -0.188580285 0.431726358 1 6.174222518 5.32702989 55421 nuclear cap binding subunit 3 "GO:0000339,GO:0000340,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0006370,GO:0016607,GO:0034518,GO:0051028,GO:0051607" RNA cap binding|RNA 7-methylguanosine cap binding|RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|7-methylguanosine mRNA capping|nuclear speck|RNA cap binding complex|mRNA transport|defense response to virus NCCRP1 2.962725795 2.080827765 3.844623824 1.847641543 0.88568489 0.829811711 1 0.045812687 0.083228997 342897 "NCCRP1, F-box associated domain containing" "GO:0005515,GO:0005737,GO:0006516,GO:0008284,GO:0016567,GO:0019005,GO:0030433,GO:0031146,GO:0061630,GO:0070062" protein binding|cytoplasm|glycoprotein catabolic process|positive regulation of cell population proliferation|protein ubiquitination|SCF ubiquitin ligase complex|ubiquitin-dependent ERAD pathway|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity|extracellular exosome NCDN 367.3968914 409.9230698 324.8707131 0.792516297 -0.335487493 0.257873257 1 6.385534392 4.97595711 23154 neurochondrin "GO:0005515,GO:0005634,GO:0005829,GO:0010008,GO:0016020,GO:0030424,GO:0030425,GO:0031175,GO:0043025,GO:0043204,GO:0045453,GO:0048168,GO:0098794" protein binding|nucleus|cytosol|endosome membrane|membrane|axon|dendrite|neuron projection development|neuronal cell body|perikaryon|bone resorption|regulation of neuronal synaptic plasticity|postsynapse NCEH1 3024.487726 2856.976522 3191.99893 1.11726467 0.159970987 0.499624025 1 33.43675133 36.7325704 57552 neutral cholesterol ester hydrolase 1 "GO:0004771,GO:0005789,GO:0005886,GO:0016020,GO:0016021,GO:0016042,GO:0016787,GO:0034383,GO:0046485" sterol esterase activity|endoplasmic reticulum membrane|plasma membrane|membrane|integral component of membrane|lipid catabolic process|hydrolase activity|low-density lipoprotein particle clearance|ether lipid metabolic process "hsa04927,hsa04934,hsa04976,hsa04979" Cortisol synthesis and secretion|Cushing syndrome|Bile secretion|Cholesterol metabolism NCF2 29.22593789 22.88910542 35.56277037 1.553698571 0.635706637 0.398543374 1 0.489598993 0.747960151 4688 neutrophil cytosolic factor 2 "GO:0001669,GO:0002479,GO:0005515,GO:0005829,GO:0006801,GO:0006909,GO:0006968,GO:0008022,GO:0009055,GO:0016020,GO:0016175,GO:0016176,GO:0022900,GO:0032010,GO:0034599,GO:0042554,GO:0043020,GO:0045087,GO:0045454,GO:0045730,GO:0048010,GO:0050790,GO:0055114" "acrosomal vesicle|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|cytosol|superoxide metabolic process|phagocytosis|cellular defense response|protein C-terminus binding|electron transfer activity|membrane|superoxide-generating NAD(P)H oxidase activity|superoxide-generating NADPH oxidase activator activity|electron transport chain|phagolysosome|cellular response to oxidative stress|superoxide anion generation|NADPH oxidase complex|innate immune response|cell redox homeostasis|respiratory burst|vascular endothelial growth factor receptor signaling pathway|regulation of catalytic activity|oxidation-reduction process" "hsa04145,hsa04380,hsa04670,hsa05020,hsa05140,hsa05418" Phagosome|Osteoclast differentiation|Leukocyte transendothelial migration|Prion disease|Leishmaniasis|Fluid shear stress and atherosclerosis NCK1 740.0606334 768.8658593 711.2554074 0.925070868 -0.112364204 0.661768364 1 8.609516952 7.831139645 4690 NCK adaptor protein 1 "GO:0000164,GO:0004860,GO:0005102,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0005840,GO:0005886,GO:0005911,GO:0006469,GO:0006930,GO:0007015,GO:0007172,GO:0008093,GO:0010976,GO:0012506,GO:0019904,GO:0030032,GO:0030159,GO:0030334,GO:0030674,GO:0030838,GO:0030971,GO:0033137,GO:0035591,GO:0036493,GO:0038096,GO:0042102,GO:0042110,GO:0045296,GO:0045944,GO:0046627,GO:0046875,GO:0048010,GO:0048013,GO:0050852,GO:0051707,GO:0060548,GO:0070262,GO:0071074,GO:1902237,GO:1903676,GO:1903679,GO:1903898,GO:1903912,GO:1990441" "protein phosphatase type 1 complex|protein kinase inhibitor activity|signaling receptor binding|protein binding|nucleus|cytoplasm|endoplasmic reticulum|cytosol|ribosome|plasma membrane|cell-cell junction|negative regulation of protein kinase activity|substrate-dependent cell migration, cell extension|actin filament organization|signal complex assembly|cytoskeletal anchor activity|positive regulation of neuron projection development|vesicle membrane|protein domain specific binding|lamellipodium assembly|signaling receptor complex adaptor activity|regulation of cell migration|protein-macromolecule adaptor activity|positive regulation of actin filament polymerization|receptor tyrosine kinase binding|negative regulation of peptidyl-serine phosphorylation|signaling adaptor activity|positive regulation of translation in response to endoplasmic reticulum stress|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of T cell proliferation|T cell activation|cadherin binding|positive regulation of transcription by RNA polymerase II|negative regulation of insulin receptor signaling pathway|ephrin receptor binding|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|T cell receptor signaling pathway|response to other organism|negative regulation of cell death|peptidyl-serine dephosphorylation|eukaryotic initiation factor eIF2 binding|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of cap-dependent translational initiation|positive regulation of cap-independent translational initiation|negative regulation of PERK-mediated unfolded protein response|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation|negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" "hsa04012,hsa04360,hsa04660,hsa05130" ErbB signaling pathway|Axon guidance|T cell receptor signaling pathway|Pathogenic Escherichia coli infection NCK2 642.6479572 608.6421213 676.653793 1.111743288 0.152823694 0.559178218 1 8.024237001 8.771612585 8440 NCK adaptor protein 2 "GO:0001771,GO:0001784,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0007015,GO:0007165,GO:0007172,GO:0007173,GO:0007176,GO:0008093,GO:0008285,GO:0012506,GO:0014069,GO:0016477,GO:0030032,GO:0030159,GO:0030838,GO:0033137,GO:0035591,GO:0036493,GO:0042102,GO:0042110,GO:0044877,GO:0045944,GO:0048010,GO:0048013,GO:0060996,GO:0097110,GO:1902237,GO:1903898,GO:1903912,GO:1990441" immunological synapse formation|phosphotyrosine residue binding|protein binding|cytoplasm|endoplasmic reticulum|cytosol|actin filament organization|signal transduction|signal complex assembly|epidermal growth factor receptor signaling pathway|regulation of epidermal growth factor-activated receptor activity|cytoskeletal anchor activity|negative regulation of cell population proliferation|vesicle membrane|postsynaptic density|cell migration|lamellipodium assembly|signaling receptor complex adaptor activity|positive regulation of actin filament polymerization|negative regulation of peptidyl-serine phosphorylation|signaling adaptor activity|positive regulation of translation in response to endoplasmic reticulum stress|positive regulation of T cell proliferation|T cell activation|protein-containing complex binding|positive regulation of transcription by RNA polymerase II|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|dendritic spine development|scaffold protein binding|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|negative regulation of PERK-mediated unfolded protein response|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation|negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress "hsa04012,hsa04360,hsa04660,hsa05130" ErbB signaling pathway|Axon guidance|T cell receptor signaling pathway|Pathogenic Escherichia coli infection NCKAP1 9137.446174 9102.581059 9172.311288 1.00766049 0.011009635 0.965251395 1 24.0049425 23.78406476 10787 NCK associated protein 1 "GO:0000902,GO:0001726,GO:0005515,GO:0005829,GO:0005925,GO:0006915,GO:0007417,GO:0010592,GO:0016021,GO:0016032,GO:0016477,GO:0016601,GO:0030027,GO:0030031,GO:0030838,GO:0030866,GO:0031209,GO:0031258,GO:0031267,GO:0031941,GO:0038096,GO:0048010,GO:0048812,GO:0070062,GO:2000601" cell morphogenesis|ruffle|protein binding|cytosol|focal adhesion|apoptotic process|central nervous system development|positive regulation of lamellipodium assembly|integral component of membrane|viral process|cell migration|Rac protein signal transduction|lamellipodium|cell projection assembly|positive regulation of actin filament polymerization|cortical actin cytoskeleton organization|SCAR complex|lamellipodium membrane|small GTPase binding|filamentous actin|Fc-gamma receptor signaling pathway involved in phagocytosis|vascular endothelial growth factor receptor signaling pathway|neuron projection morphogenesis|extracellular exosome|positive regulation of Arp2/3 complex-mediated actin nucleation "hsa04810,hsa05130,hsa05132" Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Salmonella infection NCKAP1L 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.016741571 3071 NCK associated protein 1 like "GO:0000902,GO:0001782,GO:0002262,GO:0005096,GO:0005515,GO:0005829,GO:0005886,GO:0005887,GO:0006935,GO:0016020,GO:0016477,GO:0030011,GO:0030031,GO:0030295,GO:0030593,GO:0030667,GO:0030838,GO:0030866,GO:0030890,GO:0031209,GO:0032147,GO:0032700,GO:0032715,GO:0033630,GO:0034101,GO:0035509,GO:0038096,GO:0042102,GO:0042327,GO:0042493,GO:0043029,GO:0043066,GO:0043312,GO:0043372,GO:0043378,GO:0043547,GO:0044877,GO:0045579,GO:0045588,GO:0045621,GO:0045648,GO:0048010,GO:0048812,GO:0048821,GO:0050853,GO:0060100,GO:0065003,GO:0070062,GO:0070358,GO:0090023,GO:0101003" "cell morphogenesis|B cell homeostasis|myeloid cell homeostasis|GTPase activator activity|protein binding|cytosol|plasma membrane|integral component of plasma membrane|chemotaxis|membrane|cell migration|maintenance of cell polarity|cell projection assembly|protein kinase activator activity|neutrophil chemotaxis|secretory granule membrane|positive regulation of actin filament polymerization|cortical actin cytoskeleton organization|positive regulation of B cell proliferation|SCAR complex|activation of protein kinase activity|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|positive regulation of cell adhesion mediated by integrin|erythrocyte homeostasis|negative regulation of myosin-light-chain-phosphatase activity|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of T cell proliferation|positive regulation of phosphorylation|response to drug|T cell homeostasis|negative regulation of apoptotic process|neutrophil degranulation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of GTPase activity|protein-containing complex binding|positive regulation of B cell differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of lymphocyte differentiation|positive regulation of erythrocyte differentiation|vascular endothelial growth factor receptor signaling pathway|neuron projection morphogenesis|erythrocyte development|B cell receptor signaling pathway|positive regulation of phagocytosis, engulfment|protein-containing complex assembly|extracellular exosome|actin polymerization-dependent cell motility|positive regulation of neutrophil chemotaxis|ficolin-1-rich granule membrane" "hsa04810,hsa05130,hsa05132" Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Salmonella infection NCKAP5 14.53119581 15.60620824 13.45618338 0.86223272 -0.213850783 0.895568055 1 0.067603462 0.057314514 344148 NCK associated protein 5 "GO:0001578,GO:0005575,GO:0007019,GO:0008150,GO:0035371" microtubule bundle formation|cellular_component|microtubule depolymerization|biological_process|microtubule plus-end NCKAP5L 698.3843274 734.5322011 662.2364537 0.901575796 -0.14947931 0.56235142 1 7.272844817 6.447297988 57701 NCK associated protein 5 like "GO:0001578,GO:0005515,GO:0005737,GO:0005813,GO:0007019,GO:0035371" microtubule bundle formation|protein binding|cytoplasm|centrosome|microtubule depolymerization|microtubule plus-end NCKIPSD 743.9599774 732.4513734 755.4685814 1.031424896 0.044638774 0.865587208 1 9.351575026 9.484043798 51517 NCK interacting protein with SH3 domain "GO:0005515,GO:0005829,GO:0005882,GO:0007010,GO:0008092,GO:0008180,GO:0010976,GO:0017124,GO:0038096" protein binding|cytosol|intermediate filament|cytoskeleton organization|cytoskeletal protein binding|COP9 signalosome|positive regulation of neuron projection development|SH3 domain binding|Fc-gamma receptor signaling pathway involved in phagocytosis NCL 9651.923235 9752.839736 9551.006735 0.979305207 -0.03016954 0.904506865 1 132.6429999 127.7243137 4691 nucleolin "GO:0001525,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005694,GO:0005730,GO:0005938,GO:0008022,GO:0016020,GO:0017148,GO:0036464,GO:0042162,GO:0042802,GO:0044547,GO:0048026,GO:0048027,GO:0070062,GO:1901838,GO:1990904" "angiogenesis|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|chromosome|nucleolus|cell cortex|protein C-terminus binding|membrane|negative regulation of translation|cytoplasmic ribonucleoprotein granule|telomeric DNA binding|identical protein binding|DNA topoisomerase binding|positive regulation of mRNA splicing, via spliceosome|mRNA 5'-UTR binding|extracellular exosome|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|ribonucleoprotein complex" hsa05130 Pathogenic Escherichia coli infection NCLN 970.1172475 1017.524777 922.7097178 0.906817935 -0.141115169 0.568939903 1 14.75636609 13.15741888 56926 nicalin "GO:0005515,GO:0005789,GO:0009966,GO:0016020,GO:0016021,GO:0032991,GO:0043254,GO:0050821,GO:0061635" protein binding|endoplasmic reticulum membrane|regulation of signal transduction|membrane|integral component of membrane|protein-containing complex|regulation of protein-containing complex assembly|protein stabilization|regulation of protein complex stability NCOA1 667.4782674 806.320759 528.6357758 0.655614741 -0.609079802 0.018315794 0.777852441 5.474790961 3.529290687 8648 nuclear receptor coactivator 1 "GO:0000435,GO:0000785,GO:0000977,GO:0002155,GO:0003682,GO:0003713,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0007595,GO:0008584,GO:0015721,GO:0016922,GO:0017162,GO:0019216,GO:0019899,GO:0021549,GO:0021766,GO:0021854,GO:0021987,GO:0030331,GO:0030374,GO:0032355,GO:0032526,GO:0032570,GO:0032870,GO:0032991,GO:0033142,GO:0035257,GO:0043005,GO:0043065,GO:0043967,GO:0044849,GO:0044877,GO:0045666,GO:0045893,GO:0045925,GO:0045944,GO:0046965,GO:0046983,GO:0047485,GO:0060179,GO:0060713,GO:1904017,GO:2001038" "positive regulation of transcription from RNA polymerase II promoter by galactose|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|regulation of thyroid hormone mediated signaling pathway|chromatin binding|transcription coactivator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|lactation|male gonad development|bile acid and bile salt transport|nuclear receptor binding|aryl hydrocarbon receptor binding|regulation of lipid metabolic process|enzyme binding|cerebellum development|hippocampus development|hypothalamus development|cerebral cortex development|estrogen receptor binding|nuclear receptor coactivator activity|response to estradiol|response to retinoic acid|response to progesterone|cellular response to hormone stimulus|protein-containing complex|progesterone receptor binding|nuclear hormone receptor binding|neuron projection|positive regulation of apoptotic process|histone H4 acetylation|estrous cycle|protein-containing complex binding|positive regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of female receptivity|positive regulation of transcription by RNA polymerase II|retinoid X receptor binding|protein dimerization activity|protein N-terminus binding|male mating behavior|labyrinthine layer morphogenesis|cellular response to Thyroglobulin triiodothyronine|regulation of cellular response to drug" "hsa04915,hsa04919,hsa05200,hsa05224" Estrogen signaling pathway|Thyroid hormone signaling pathway|Pathways in cancer|Breast cancer NCOA2 921.886457 949.8978749 893.8750391 0.941022254 -0.087699254 0.726499565 1 2.797081425 2.588070972 10499 nuclear receptor coactivator 2 "GO:0000122,GO:0000785,GO:0000978,GO:0001162,GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0010906,GO:0015721,GO:0016604,GO:0016922,GO:0017162,GO:0019216,GO:0019904,GO:0030374,GO:0032570,GO:0032870,GO:0032922,GO:0032991,GO:0035257,GO:0045475,GO:0045944,GO:0046983,GO:1904017" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|chromatin binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|regulation of glucose metabolic process|bile acid and bile salt transport|nuclear body|nuclear receptor binding|aryl hydrocarbon receptor binding|regulation of lipid metabolic process|protein domain specific binding|nuclear receptor coactivator activity|response to progesterone|cellular response to hormone stimulus|circadian regulation of gene expression|protein-containing complex|nuclear hormone receptor binding|locomotor rhythm|positive regulation of transcription by RNA polymerase II|protein dimerization activity|cellular response to Thyroglobulin triiodothyronine" "hsa04915,hsa04919" Estrogen signaling pathway|Thyroid hormone signaling pathway NCOA3 1898.06755 2025.68583 1770.449271 0.873999929 -0.194294933 0.412355452 1 13.54895722 11.64363137 8202 nuclear receptor coactivator 3 "GO:0000785,GO:0000993,GO:0003713,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016573,GO:0016922,GO:0030374,GO:0032870,GO:0032991,GO:0035257,GO:0035624,GO:0043697,GO:0045618,GO:0045944,GO:0046966,GO:0046983,GO:0047485,GO:0070062,GO:0071392,GO:0097718,GO:1902459,GO:2000035" chromatin|RNA polymerase II complex binding|transcription coactivator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|histone acetylation|nuclear receptor binding|nuclear receptor coactivator activity|cellular response to hormone stimulus|protein-containing complex|nuclear hormone receptor binding|receptor transactivation|cell dedifferentiation|positive regulation of keratinocyte differentiation|positive regulation of transcription by RNA polymerase II|thyroid hormone receptor binding|protein dimerization activity|protein N-terminus binding|extracellular exosome|cellular response to estradiol stimulus|disordered domain specific binding|positive regulation of stem cell population maintenance|regulation of stem cell division "hsa01522,hsa04915,hsa04919,hsa05200,hsa05224" Endocrine resistance|Estrogen signaling pathway|Thyroid hormone signaling pathway|Pathways in cancer|Breast cancer NCOA4 4364.894165 4461.294729 4268.493601 0.956783593 -0.063735444 0.790236342 1 54.44571236 51.22106244 8031 nuclear receptor coactivator 4 "GO:0003713,GO:0005634,GO:0006622,GO:0006879,GO:0008584,GO:0009725,GO:0030520,GO:0044754,GO:0045893,GO:0071391,GO:0071394" "transcription coactivator activity|nucleus|protein targeting to lysosome|cellular iron ion homeostasis|male gonad development|response to hormone|intracellular estrogen receptor signaling pathway|autolysosome|positive regulation of transcription, DNA-templated|cellular response to estrogen stimulus|cellular response to testosterone stimulus" "hsa04216,hsa05200,hsa05216" Ferroptosis|Pathways in cancer|Thyroid cancer NCOA5 527.9382755 637.7737101 418.1028409 0.655566127 -0.609186783 0.02401832 0.848442542 10.48254103 6.757005229 57727 nuclear receptor coactivator 5 "GO:0000122,GO:0003682,GO:0003714,GO:0003723,GO:0005515,GO:0005615,GO:0005654,GO:0015629,GO:0042593,GO:0046627" negative regulation of transcription by RNA polymerase II|chromatin binding|transcription corepressor activity|RNA binding|protein binding|extracellular space|nucleoplasm|actin cytoskeleton|glucose homeostasis|negative regulation of insulin receptor signaling pathway NCOA6 2071.88648 2299.314681 1844.45828 0.802177403 -0.318006768 0.178778646 1 12.69503399 10.01325948 23054 nuclear receptor coactivator 6 "GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006352,GO:0006974,GO:0007420,GO:0007507,GO:0009725,GO:0019216,GO:0019899,GO:0030099,GO:0030331,GO:0030374,GO:0035097,GO:0043231,GO:0045893,GO:0045944,GO:0046965,GO:0046966,GO:0051427" "chromatin binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|DNA-templated transcription, initiation|cellular response to DNA damage stimulus|brain development|heart development|response to hormone|regulation of lipid metabolic process|enzyme binding|myeloid cell differentiation|estrogen receptor binding|nuclear receptor coactivator activity|histone methyltransferase complex|intracellular membrane-bounded organelle|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|retinoid X receptor binding|thyroid hormone receptor binding|hormone receptor binding" NCOA7 647.3788951 694.9964736 599.7613165 0.862970302 -0.212617184 0.413885661 1 4.894521569 4.153146734 135112 nuclear receptor coactivator 7 "GO:0005515,GO:0005634,GO:0006979,GO:0030374,GO:0035257,GO:0045944,GO:1900408,GO:1902083,GO:1903204" protein binding|nucleus|response to oxidative stress|nuclear receptor coactivator activity|nuclear hormone receptor binding|positive regulation of transcription by RNA polymerase II|negative regulation of cellular response to oxidative stress|negative regulation of peptidyl-cysteine S-nitrosylation|negative regulation of oxidative stress-induced neuron death NCOR1 3702.355771 4415.516518 2989.195023 0.676975165 -0.562825186 0.018086182 0.773499658 18.39706466 12.2459491 9611 nuclear receptor corepressor 1 "GO:0000118,GO:0000122,GO:0000785,GO:0000976,GO:0001102,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006325,GO:0007623,GO:0016020,GO:0016580,GO:0017053,GO:0019216,GO:0035257,GO:0042826,GO:0045475,GO:0045820,GO:0045892,GO:0045922,GO:0046329,GO:0046966,GO:0051225,GO:0060766,GO:0072686,GO:1903799" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytosol|chromatin organization|circadian rhythm|membrane|Sin3 complex|transcription repressor complex|regulation of lipid metabolic process|nuclear hormone receptor binding|histone deacetylase binding|locomotor rhythm|negative regulation of glycolytic process|negative regulation of transcription, DNA-templated|negative regulation of fatty acid metabolic process|negative regulation of JNK cascade|thyroid hormone receptor binding|spindle assembly|negative regulation of androgen receptor signaling pathway|mitotic spindle|negative regulation of production of miRNAs involved in gene silencing by miRNA" "hsa01522,hsa04919,hsa05202" Endocrine resistance|Thyroid hormone signaling pathway|Transcriptional misregulation in cancer MYB NCOR2 3189.808509 3349.092288 3030.524729 0.904879433 -0.144202517 0.543191013 1 19.85722698 17.6677195 9612 nuclear receptor corepressor 2 "GO:0000118,GO:0000122,GO:0000785,GO:0000977,GO:0003682,GO:0003714,GO:0005112,GO:0005515,GO:0005634,GO:0005654,GO:0007595,GO:0010243,GO:0010565,GO:0016020,GO:0016363,GO:0016604,GO:0017053,GO:0019216,GO:0032355,GO:0035257,GO:0035259,GO:0042826,GO:0044849,GO:0044877,GO:0045892,GO:0046965,GO:0047485,GO:0060766,GO:1903799" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|chromatin binding|transcription corepressor activity|Notch binding|protein binding|nucleus|nucleoplasm|lactation|response to organonitrogen compound|regulation of cellular ketone metabolic process|membrane|nuclear matrix|nuclear body|transcription repressor complex|regulation of lipid metabolic process|response to estradiol|nuclear hormone receptor binding|glucocorticoid receptor binding|histone deacetylase binding|estrous cycle|protein-containing complex binding|negative regulation of transcription, DNA-templated|retinoid X receptor binding|protein N-terminus binding|negative regulation of androgen receptor signaling pathway|negative regulation of production of miRNAs involved in gene silencing by miRNA" "hsa04330,hsa05169" Notch signaling pathway|Epstein-Barr virus infection MYB NCR3LG1 113.8366158 149.8195991 77.85363244 0.519649184 -0.944390108 0.034844975 0.95006405 1.187523637 0.606769428 374383 natural killer cell cytotoxicity receptor 3 ligand 1 "GO:0005515,GO:0005886,GO:0016021,GO:0050776" protein binding|plasma membrane|integral component of membrane|regulation of immune response NCS1 1459.972205 1450.336952 1469.607457 1.013286915 0.019042736 0.939535402 1 14.39765951 14.34483351 23413 neuronal calcium sensor 1 "GO:0000287,GO:0005245,GO:0005509,GO:0005515,GO:0005737,GO:0005794,GO:0005886,GO:0010975,GO:0014069,GO:0019901,GO:0030425,GO:0031045,GO:0043231,GO:0044305,GO:0045921,GO:0048015,GO:0048471,GO:0070588,GO:0098978,GO:0099509,GO:0099523,GO:0099524,GO:0099626,GO:2000300" magnesium ion binding|voltage-gated calcium channel activity|calcium ion binding|protein binding|cytoplasm|Golgi apparatus|plasma membrane|regulation of neuron projection development|postsynaptic density|protein kinase binding|dendrite|dense core granule|intracellular membrane-bounded organelle|calyx of Held|positive regulation of exocytosis|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|calcium ion transmembrane transport|glutamatergic synapse|regulation of presynaptic cytosolic calcium ion concentration|presynaptic cytosol|postsynaptic cytosol|voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels|regulation of synaptic vesicle exocytosis NCSTN 1910.285175 2018.402932 1802.167417 0.892868014 -0.163481167 0.490566021 1 28.42925702 24.95881451 23385 nicastrin "GO:0002262,GO:0004175,GO:0005515,GO:0005739,GO:0005765,GO:0005769,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0005925,GO:0006508,GO:0006509,GO:0007212,GO:0007215,GO:0007220,GO:0007611,GO:0008021,GO:0010008,GO:0010950,GO:0016020,GO:0016021,GO:0016485,GO:0021549,GO:0022010,GO:0030534,GO:0030674,GO:0031293,GO:0034205,GO:0035333,GO:0035577,GO:0042098,GO:0042383,GO:0042470,GO:0042982,GO:0042983,GO:0042986,GO:0042987,GO:0043065,GO:0043085,GO:0043312,GO:0044267,GO:0048013,GO:0050673,GO:0051117,GO:0051402,GO:0070062,GO:0070765,GO:0070851,GO:0071277,GO:0099056,GO:1900271,GO:1990926" "myeloid cell homeostasis|endopeptidase activity|protein binding|mitochondrion|lysosomal membrane|early endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|focal adhesion|proteolysis|membrane protein ectodomain proteolysis|dopamine receptor signaling pathway|glutamate receptor signaling pathway|Notch receptor processing|learning or memory|synaptic vesicle|endosome membrane|positive regulation of endopeptidase activity|membrane|integral component of membrane|protein processing|cerebellum development|central nervous system myelination|adult behavior|protein-macromolecule adaptor activity|membrane protein intracellular domain proteolysis|amyloid-beta formation|Notch receptor processing, ligand-dependent|azurophil granule membrane|T cell proliferation|sarcolemma|melanosome|amyloid precursor protein metabolic process|amyloid precursor protein biosynthetic process|positive regulation of amyloid precursor protein biosynthetic process|amyloid precursor protein catabolic process|positive regulation of apoptotic process|positive regulation of catalytic activity|neutrophil degranulation|cellular protein metabolic process|ephrin receptor signaling pathway|epithelial cell proliferation|ATPase binding|neuron apoptotic process|extracellular exosome|gamma-secretase complex|growth factor receptor binding|cellular response to calcium ion|integral component of presynaptic membrane|regulation of long-term synaptic potentiation|short-term synaptic potentiation" "hsa04330,hsa05010" Notch signaling pathway|Alzheimer disease NDC1 2023.745623 2107.878526 1939.612719 0.920172911 -0.12002311 0.61292125 1 23.72281797 21.46381413 55706 NDC1 transmembrane nucleoporin "GO:0005635,GO:0005643,GO:0005737,GO:0005886,GO:0006110,GO:0006406,GO:0006409,GO:0006999,GO:0007129,GO:0007283,GO:0015031,GO:0015629,GO:0016020,GO:0016021,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0043657,GO:0051292,GO:0051664,GO:0060964,GO:0070762,GO:0075733,GO:1900034" nuclear envelope|nuclear pore|cytoplasm|plasma membrane|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|nuclear pore organization|homologous chromosome pairing at meiosis|spermatogenesis|protein transport|actin cytoskeleton|membrane|integral component of membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|host cell|nuclear pore complex assembly|nuclear pore localization|regulation of gene silencing by miRNA|nuclear pore transmembrane ring|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NDC80 1705.595398 1729.167873 1682.022923 0.97273547 -0.03988057 0.868932609 1 43.40663749 41.51662824 10403 NDC80 kinetochore complex component "GO:0000070,GO:0000132,GO:0000278,GO:0000775,GO:0000776,GO:0000777,GO:0000778,GO:0000942,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0007052,GO:0007059,GO:0008608,GO:0016020,GO:0031262,GO:0042802,GO:0051298,GO:0051301,GO:0051310,GO:0051315,GO:0051383,GO:0090267,GO:1905342" "mitotic sister chromatid segregation|establishment of mitotic spindle orientation|mitotic cell cycle|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|condensed nuclear chromosome kinetochore|condensed nuclear chromosome outer kinetochore|protein binding|nucleus|nucleoplasm|centrosome|cytosol|mitotic spindle organization|chromosome segregation|attachment of spindle microtubules to kinetochore|membrane|Ndc80 complex|identical protein binding|centrosome duplication|cell division|metaphase plate congression|attachment of mitotic spindle microtubules to kinetochore|kinetochore organization|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of protein localization to kinetochore" NDE1 1410.051231 1502.357647 1317.744816 0.877117921 -0.189157281 0.430144841 1 11.74942356 10.13317921 54820 nudE neurodevelopment protein 1 "GO:0000086,GO:0000132,GO:0000776,GO:0000777,GO:0005515,GO:0005813,GO:0005829,GO:0005871,GO:0005874,GO:0007020,GO:0007059,GO:0007100,GO:0008017,GO:0010389,GO:0016020,GO:0016477,GO:0021987,GO:0030154,GO:0031616,GO:0032154,GO:0042802,GO:0047496,GO:0051298,GO:0051301,GO:0051303,GO:0051642,GO:0097711,GO:2000574" G2/M transition of mitotic cell cycle|establishment of mitotic spindle orientation|kinetochore|condensed chromosome kinetochore|protein binding|centrosome|cytosol|kinesin complex|microtubule|microtubule nucleation|chromosome segregation|mitotic centrosome separation|microtubule binding|regulation of G2/M transition of mitotic cell cycle|membrane|cell migration|cerebral cortex development|cell differentiation|spindle pole centrosome|cleavage furrow|identical protein binding|vesicle transport along microtubule|centrosome duplication|cell division|establishment of chromosome localization|centrosome localization|ciliary basal body-plasma membrane docking|regulation of microtubule motor activity NDEL1 1263.878111 1197.516379 1330.239843 1.110832275 0.151641 0.530791564 1 15.02686297 16.41300093 81565 nudE neurodevelopment protein 1 like 1 "GO:0000132,GO:0000776,GO:0000777,GO:0001764,GO:0001833,GO:0005515,GO:0005635,GO:0005813,GO:0005819,GO:0005829,GO:0005871,GO:0005874,GO:0006508,GO:0007020,GO:0007059,GO:0007100,GO:0008017,GO:0008021,GO:0008090,GO:0008286,GO:0010975,GO:0016477,GO:0021799,GO:0021955,GO:0031252,GO:0032418,GO:0033157,GO:0042802,GO:0043014,GO:0043203,GO:0043547,GO:0044877,GO:0045773,GO:0047496,GO:0048487,GO:0048680,GO:0051081,GO:0051303,GO:0051642,GO:0060052,GO:0060053,GO:0070012,GO:0090630,GO:0090724,GO:1900029,GO:1904115,GO:1990138,GO:2000574" establishment of mitotic spindle orientation|kinetochore|condensed chromosome kinetochore|neuron migration|inner cell mass cell proliferation|protein binding|nuclear envelope|centrosome|spindle|cytosol|kinesin complex|microtubule|proteolysis|microtubule nucleation|chromosome segregation|mitotic centrosome separation|microtubule binding|synaptic vesicle|retrograde axonal transport|insulin receptor signaling pathway|regulation of neuron projection development|cell migration|cerebral cortex radially oriented cell migration|central nervous system neuron axonogenesis|cell leading edge|lysosome localization|regulation of intracellular protein transport|identical protein binding|alpha-tubulin binding|axon hillock|positive regulation of GTPase activity|protein-containing complex binding|positive regulation of axon extension|vesicle transport along microtubule|beta-tubulin binding|positive regulation of axon regeneration|nuclear envelope disassembly|establishment of chromosome localization|centrosome localization|neurofilament cytoskeleton organization|neurofilament cytoskeleton|oligopeptidase activity|activation of GTPase activity|central region of growth cone|positive regulation of ruffle assembly|axon cytoplasm|neuron projection extension|regulation of microtubule motor activity NDFIP1 1791.128217 1754.137806 1828.118628 1.042175034 0.0595976 0.803509079 1 26.19337178 26.84128177 80762 Nedd4 family interacting protein 1 "GO:0000139,GO:0002761,GO:0002829,GO:0005515,GO:0005576,GO:0005783,GO:0005794,GO:0005938,GO:0006511,GO:0006879,GO:0007034,GO:0010008,GO:0010629,GO:0016021,GO:0030001,GO:0030425,GO:0031398,GO:0032410,GO:0032713,GO:0042130,GO:0043123,GO:0045202,GO:0045619,GO:0045732,GO:0048294,GO:0048302,GO:0048471,GO:0050699,GO:0050728,GO:0051224" Golgi membrane|regulation of myeloid leukocyte differentiation|negative regulation of type 2 immune response|protein binding|extracellular region|endoplasmic reticulum|Golgi apparatus|cell cortex|ubiquitin-dependent protein catabolic process|cellular iron ion homeostasis|vacuolar transport|endosome membrane|negative regulation of gene expression|integral component of membrane|metal ion transport|dendrite|positive regulation of protein ubiquitination|negative regulation of transporter activity|negative regulation of interleukin-4 production|negative regulation of T cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB signaling|synapse|regulation of lymphocyte differentiation|positive regulation of protein catabolic process|negative regulation of isotype switching to IgE isotypes|regulation of isotype switching to IgG isotypes|perinuclear region of cytoplasm|WW domain binding|negative regulation of inflammatory response|negative regulation of protein transport NDFIP2 1376.853565 1198.556793 1555.150337 1.297519105 0.375755781 0.117122992 1 12.64875879 16.13737348 54602 Nedd4 family interacting protein 2 "GO:0000139,GO:0005515,GO:0005737,GO:0005739,GO:0005783,GO:0005794,GO:0006511,GO:0007034,GO:0010629,GO:0016021,GO:0030001,GO:0031398,GO:0032410,GO:0032585,GO:0043123,GO:0043231,GO:0048471,GO:0050699,GO:0051224" Golgi membrane|protein binding|cytoplasm|mitochondrion|endoplasmic reticulum|Golgi apparatus|ubiquitin-dependent protein catabolic process|vacuolar transport|negative regulation of gene expression|integral component of membrane|metal ion transport|positive regulation of protein ubiquitination|negative regulation of transporter activity|multivesicular body membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|WW domain binding|negative regulation of protein transport NDNF 31.42565255 30.1720026 32.6793025 1.083100215 0.115166736 0.918052131 1 0.170052205 0.181101517 79625 neuron derived neurotrophic factor "GO:0001525,GO:0001764,GO:0002931,GO:0005539,GO:0005576,GO:0005615,GO:0007263,GO:0008201,GO:0010811,GO:0010976,GO:0019800,GO:0021828,GO:0030198,GO:0031012,GO:0043524,GO:0044344,GO:0061042,GO:0071456,GO:2000352" angiogenesis|neuron migration|response to ischemia|glycosaminoglycan binding|extracellular region|extracellular space|nitric oxide mediated signal transduction|heparin binding|positive regulation of cell-substrate adhesion|positive regulation of neuron projection development|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|gonadotrophin-releasing hormone neuronal migration to the hypothalamus|extracellular matrix organization|extracellular matrix|negative regulation of neuron apoptotic process|cellular response to fibroblast growth factor stimulus|vascular wound healing|cellular response to hypoxia|negative regulation of endothelial cell apoptotic process NDOR1 906.234975 1031.050158 781.4197922 0.757887273 -0.399944815 0.106914948 1 11.2826024 8.407852354 27158 NADPH dependent diflavin oxidoreductase 1 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0008219,GO:0010181,GO:0016226,GO:0016491,GO:0016709,GO:0036245,GO:0045111,GO:0048471,GO:0050660,GO:0050661,GO:0055114" "protein binding|nucleoplasm|cytoplasm|cytosol|cell death|FMN binding|iron-sulfur cluster assembly|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|cellular response to menadione|intermediate filament cytoskeleton|perinuclear region of cytoplasm|flavin adenine dinucleotide binding|NADP binding|oxidation-reduction process" NDP 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.032300743 0.117363054 4693 norrin cystine knot growth factor NDP "GO:0001890,GO:0005109,GO:0005125,GO:0005515,GO:0005615,GO:0007033,GO:0007399,GO:0007601,GO:0009986,GO:0016055,GO:0031012,GO:0035426,GO:0042803,GO:0045893,GO:0051091,GO:0061299,GO:0062023,GO:0110135" "placenta development|frizzled binding|cytokine activity|protein binding|extracellular space|vacuole organization|nervous system development|visual perception|cell surface|Wnt signaling pathway|extracellular matrix|extracellular matrix-cell signaling|protein homodimerization activity|positive regulation of transcription, DNA-templated|positive regulation of DNA-binding transcription factor activity|retina vasculature morphogenesis in camera-type eye|collagen-containing extracellular matrix|Norrin signaling pathway" NDRG1 5553.630846 4493.547559 6613.714133 1.471824666 0.557605817 0.02106826 0.821508434 48.20349235 69.75988555 10397 N-myc downstream regulated 1 "GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0005874,GO:0005886,GO:0005912,GO:0007165,GO:0008017,GO:0008285,GO:0010038,GO:0015630,GO:0030330,GO:0031267,GO:0032287,GO:0042981,GO:0043015,GO:0045296,GO:0045576,GO:0048471,GO:0055038,GO:0070062,GO:0071456,GO:0098978,GO:0099173" "protein binding|nucleus|cytoplasm|centrosome|cytosol|microtubule|plasma membrane|adherens junction|signal transduction|microtubule binding|negative regulation of cell population proliferation|response to metal ion|microtubule cytoskeleton|DNA damage response, signal transduction by p53 class mediator|small GTPase binding|peripheral nervous system myelin maintenance|regulation of apoptotic process|gamma-tubulin binding|cadherin binding|mast cell activation|perinuclear region of cytoplasm|recycling endosome membrane|extracellular exosome|cellular response to hypoxia|glutamatergic synapse|postsynapse organization" NDRG2 62.73241821 57.22276355 68.24207288 1.192568633 0.254072296 0.664137457 1 0.837365977 0.981905906 57447 NDRG family member 2 "GO:0001818,GO:0003674,GO:0005515,GO:0005634,GO:0005737,GO:0005794,GO:0005829,GO:0007165,GO:0010574,GO:0016055,GO:0021762,GO:0030154,GO:0030426,GO:0048471,GO:0048662,GO:0070062,GO:0070373,GO:0090361" negative regulation of cytokine production|molecular_function|protein binding|nucleus|cytoplasm|Golgi apparatus|cytosol|signal transduction|regulation of vascular endothelial growth factor production|Wnt signaling pathway|substantia nigra development|cell differentiation|growth cone|perinuclear region of cytoplasm|negative regulation of smooth muscle cell proliferation|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|regulation of platelet-derived growth factor production NDRG3 1998.23659 1904.997819 2091.47536 1.097888585 0.134731656 0.569983582 1 28.17019462 30.41020135 57446 NDRG family member 3 "GO:0003674,GO:0005737,GO:0007165,GO:0007283,GO:0030154,GO:0030308,GO:0070062" molecular_function|cytoplasm|signal transduction|spermatogenesis|cell differentiation|negative regulation of cell growth|extracellular exosome NDRG4 503.0582754 464.0245917 542.0919592 1.16823972 0.224336343 0.413109384 1 5.203643542 5.977377519 65009 NDRG family member 4 "GO:0001947,GO:0003674,GO:0005515,GO:0005737,GO:0005739,GO:0005789,GO:0005829,GO:0007165,GO:0007420,GO:0008542,GO:0010642,GO:0010976,GO:0014912,GO:0016323,GO:0030154,GO:0031253,GO:0035050,GO:0048278,GO:0048662,GO:0060038,GO:0060973,GO:0070374,GO:2001135" heart looping|molecular_function|protein binding|cytoplasm|mitochondrion|endoplasmic reticulum membrane|cytosol|signal transduction|brain development|visual learning|negative regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of neuron projection development|negative regulation of smooth muscle cell migration|basolateral plasma membrane|cell differentiation|cell projection membrane|embryonic heart tube development|vesicle docking|negative regulation of smooth muscle cell proliferation|cardiac muscle cell proliferation|cell migration involved in heart development|positive regulation of ERK1 and ERK2 cascade|regulation of endocytic recycling NDST1 1943.380274 2079.787351 1806.973197 0.868825938 -0.20286092 0.391784929 1 13.51612621 11.54665514 3340 N-deacetylase and N-sulfotransferase 1 "GO:0000139,GO:0003279,GO:0005515,GO:0005794,GO:0006024,GO:0006477,GO:0006954,GO:0007585,GO:0008283,GO:0008543,GO:0015014,GO:0015016,GO:0016021,GO:0019213,GO:0030210,GO:0030900,GO:0030901,GO:0035904,GO:0043410,GO:0045880,GO:0048702,GO:0048703,GO:0060976,GO:0102140" "Golgi membrane|cardiac septum development|protein binding|Golgi apparatus|glycosaminoglycan biosynthetic process|protein sulfation|inflammatory response|respiratory gaseous exchange by respiratory system|cell population proliferation|fibroblast growth factor receptor signaling pathway|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|[heparan sulfate]-glucosamine N-sulfotransferase activity|integral component of membrane|deacetylase activity|heparin biosynthetic process|forebrain development|midbrain development|aorta development|positive regulation of MAPK cascade|positive regulation of smoothened signaling pathway|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|coronary vasculature development|heparan sulfate N-deacetylase activity" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin NDST2 659.760066 679.3902654 640.1298667 0.942212303 -0.085875924 0.744313023 1 7.547420857 6.992275269 8509 N-deacetylase and N-sulfotransferase 2 "GO:0000139,GO:0005794,GO:0006024,GO:0015014,GO:0015016,GO:0016021,GO:0019213,GO:0030210" "Golgi membrane|Golgi apparatus|glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|[heparan sulfate]-glucosamine N-sulfotransferase activity|integral component of membrane|deacetylase activity|heparin biosynthetic process" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin NDST3 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.004171987 0.011369022 9348 N-deacetylase and N-sulfotransferase 3 "GO:0000139,GO:0005575,GO:0005794,GO:0015012,GO:0015014,GO:0015016,GO:0016021,GO:0019213,GO:0030210,GO:0102140" "Golgi membrane|cellular_component|Golgi apparatus|heparan sulfate proteoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|[heparan sulfate]-glucosamine N-sulfotransferase activity|integral component of membrane|deacetylase activity|heparin biosynthetic process|heparan sulfate N-deacetylase activity" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin NDST4 5.484502575 5.202069413 5.766935736 1.108584926 0.148719296 1 1 0.041215096 0.044925866 64579 N-deacetylase and N-sulfotransferase 4 "GO:0000139,GO:0005794,GO:0015014,GO:0015016,GO:0016021,GO:0019213,GO:0030210" "Golgi membrane|Golgi apparatus|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|[heparan sulfate]-glucosamine N-sulfotransferase activity|integral component of membrane|deacetylase activity|heparin biosynthetic process" hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin NDUFA1 1198.466015 1032.090572 1364.841458 1.322404734 0.403163794 0.095984422 1 130.8331993 170.1192797 4694 NADH:ubiquinone oxidoreductase subunit A1 "GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0016021,GO:0031966,GO:0032981" "mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA10 1149.144506 1087.232507 1211.056505 1.11388916 0.155605682 0.523284162 1 6.833541476 7.484434481 4705 NADH:ubiquinone oxidoreductase subunit A10 "GO:0005737,GO:0005739,GO:0005743,GO:0005747,GO:0005759,GO:0006120,GO:0008137,GO:0032981" "cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA11 986.4430362 853.1393838 1119.746689 1.312501462 0.39231903 0.110989802 1 17.26601475 22.28245726 126328 NADH:ubiquinone oxidoreductase subunit A11 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0016021,GO:0032981" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|integral component of membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA12 835.6610524 755.3404788 915.9816261 1.212673823 0.278191556 0.266887004 1 71.72799483 85.52712466 55967 NADH:ubiquinone oxidoreductase subunit A12 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0005829,GO:0006120,GO:0006979,GO:0007585,GO:0008137,GO:0009055,GO:0032981,GO:0042775" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|cytosol|mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|respiratory gaseous exchange by respiratory system|NADH dehydrogenase (ubiquinone) activity|electron transfer activity|mitochondrial respiratory chain complex I assembly|mitochondrial ATP synthesis coupled electron transport" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA13 1475.267026 1359.820945 1590.713107 1.169796004 0.226256966 0.343878496 1 139.2920241 160.2166185 51079 NADH:ubiquinone oxidoreductase subunit A13 "GO:0003954,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0005743,GO:0005746,GO:0005747,GO:0006120,GO:0008137,GO:0010952,GO:0016021,GO:0016032,GO:0030308,GO:0031966,GO:0032981,GO:0035458,GO:0043280,GO:0045039,GO:0045732,GO:0045892,GO:0071300,GO:0072593,GO:0097190,GO:2001243" "NADH dehydrogenase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respirasome|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|positive regulation of peptidase activity|integral component of membrane|viral process|negative regulation of cell growth|mitochondrial membrane|mitochondrial respiratory chain complex I assembly|cellular response to interferon-beta|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein insertion into mitochondrial inner membrane|positive regulation of protein catabolic process|negative regulation of transcription, DNA-templated|cellular response to retinoic acid|reactive oxygen species metabolic process|apoptotic signaling pathway|negative regulation of intrinsic apoptotic signaling pathway" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA2 598.4058295 481.7116277 715.1000313 1.484498173 0.569975318 0.030377253 0.895820653 36.93687388 53.91517046 4695 NADH:ubiquinone oxidoreductase subunit A2 "GO:0001835,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0031966,GO:0032981" "blastocyst hatching|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA3 509.1818718 473.3883166 544.975427 1.151222808 0.20316708 0.457827595 1 18.50832557 20.95065929 4696 NADH:ubiquinone oxidoreductase subunit A3 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0016021,GO:0032981" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA4 1874.982143 1671.945109 2078.019177 1.242875239 0.313681484 0.185500894 1 43.84699636 53.58442351 4697 NDUFA4 mitochondrial complex associated "GO:0004129,GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0005751,GO:0006120,GO:0006123,GO:0008137,GO:0016021,GO:0044877,GO:1902600" "cytochrome-c oxidase activity|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial respiratory chain complex IV|mitochondrial electron transport, NADH to ubiquinone|mitochondrial electron transport, cytochrome c to oxygen|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|protein-containing complex binding|proton transmembrane transport" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA4L2 17.17185948 21.84869154 12.49502743 0.571889049 -0.806192815 0.388176961 1 0.981502114 0.551917543 56901 NDUFA4 mitochondrial complex associated like 2 "GO:0004129,GO:0005751,GO:0022900,GO:1902600" cytochrome-c oxidase activity|mitochondrial respiratory chain complex IV|electron transport chain|proton transmembrane transport "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA5 961.7354146 847.9373144 1075.533515 1.268411587 0.343022962 0.164500092 1 6.420666292 8.007767916 4698 NADH:ubiquinone oxidoreductase subunit A5 "GO:0005515,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0022904,GO:0032981" "protein binding|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|respiratory electron transport chain|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA6 896.1151124 702.2793708 1089.950854 1.552018897 0.634146123 0.010828771 0.620526829 34.96208888 53.35382449 4700 NADH:ubiquinone oxidoreductase subunit A6 "GO:0005743,GO:0005747,GO:0006120,GO:0006979,GO:0008137,GO:0031966,GO:0032981" "mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|NADH dehydrogenase (ubiquinone) activity|mitochondrial membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA7 394.7753593 346.4578229 443.0928957 1.27892305 0.354929463 0.221957275 1 31.87899525 40.08853803 4701 NADH:ubiquinone oxidoreductase subunit A7 "GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0005761,GO:0006120,GO:0008137,GO:0032543,GO:0032981" "structural constituent of ribosome|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial ribosome|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial translation|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA8 1148.862687 991.5144302 1306.210944 1.317389747 0.397682227 0.101718997 1 40.3010684 52.203788 4702 NADH:ubiquinone oxidoreductase subunit A8 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0005758,GO:0006120,GO:0008137,GO:0032981,GO:0044877" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial intermembrane space|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly|protein-containing complex binding" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFA9 1168.947583 1039.373469 1298.521697 1.249331194 0.321155982 0.185707838 1 6.638278092 8.154628944 4704 NADH:ubiquinone oxidoreductase subunit A9 "GO:0003954,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005747,GO:0005759,GO:0006120,GO:0006814,GO:0007623,GO:0008137,GO:0009749,GO:0031966,GO:0032981,GO:0044877,GO:1901006" "NADH dehydrogenase activity|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|sodium ion transport|circadian rhythm|NADH dehydrogenase (ubiquinone) activity|response to glucose|mitochondrial membrane|mitochondrial respiratory chain complex I assembly|protein-containing complex binding|ubiquinone-6 biosynthetic process" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFAB1 847.6113352 715.8047513 979.4179192 1.368275242 0.452358472 0.070362568 1 49.41938419 66.48780212 4706 NADH:ubiquinone oxidoreductase subunit AB1 "GO:0000035,GO:0000036,GO:0005504,GO:0005509,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005747,GO:0005759,GO:0005762,GO:0006120,GO:0006633,GO:0008137,GO:0009249,GO:0031966,GO:0032981" "acyl binding|acyl carrier activity|fatty acid binding|calcium ion binding|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial large ribosomal subunit|mitochondrial electron transport, NADH to ubiquinone|fatty acid biosynthetic process|NADH dehydrogenase (ubiquinone) activity|protein lipoylation|mitochondrial membrane|mitochondrial respiratory chain complex I assembly" "hsa00061,hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Fatty acid biosynthesis|Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFAF1 146.3970314 146.6983575 146.0957053 0.995891896 -0.005938949 1 1 5.171084357 5.063665389 51103 NADH:ubiquinone oxidoreductase complex assembly factor 1 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0005759,GO:0005829,GO:0006120,GO:0010257,GO:0032981,GO:0051082,GO:0051131,GO:0065003" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial matrix|cytosol|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase complex assembly|mitochondrial respiratory chain complex I assembly|unfolded protein binding|chaperone-mediated protein complex assembly|protein-containing complex assembly" hsa04714 Thermogenesis NDUFAF2 324.3386022 326.6899591 321.9872453 0.985604963 -0.020918573 0.956681093 1 27.58677641 26.73468155 91942 NADH:ubiquinone oxidoreductase complex assembly factor 2 "GO:0005515,GO:0005739,GO:0005743,GO:0008137,GO:0009055,GO:0022900,GO:0032981,GO:0044877" protein binding|mitochondrion|mitochondrial inner membrane|NADH dehydrogenase (ubiquinone) activity|electron transfer activity|electron transport chain|mitochondrial respiratory chain complex I assembly|protein-containing complex binding hsa04714 Thermogenesis NDUFAF3 789.1443682 707.4814402 870.8072961 1.230855322 0.299661194 0.234811915 1 25.65012511 31.04328516 25915 NADH:ubiquinone oxidoreductase complex assembly factor 3 "GO:0005515,GO:0005634,GO:0005743,GO:0032981" protein binding|nucleus|mitochondrial inner membrane|mitochondrial respiratory chain complex I assembly hsa04714 Thermogenesis NDUFAF4 180.3840897 181.0320156 179.7361638 0.992841864 -0.010364146 0.994901241 1 4.013853739 3.918436407 29078 NADH:ubiquinone oxidoreductase complex assembly factor 4 "GO:0005515,GO:0005516,GO:0005739,GO:0005743,GO:0031966,GO:0032981" protein binding|calmodulin binding|mitochondrion|mitochondrial inner membrane|mitochondrial membrane|mitochondrial respiratory chain complex I assembly hsa04714 Thermogenesis NDUFAF5 227.2278665 212.2444321 242.2113009 1.141190365 0.190539472 0.589353366 1 4.747315696 5.326934885 79133 NADH:ubiquinone oxidoreductase complex assembly factor 5 "GO:0003674,GO:0005515,GO:0005739,GO:0005743,GO:0008168,GO:0016491,GO:0030961,GO:0031314,GO:0032259,GO:0032981,GO:0055114" molecular_function|protein binding|mitochondrion|mitochondrial inner membrane|methyltransferase activity|oxidoreductase activity|peptidyl-arginine hydroxylation|extrinsic component of mitochondrial inner membrane|methylation|mitochondrial respiratory chain complex I assembly|oxidation-reduction process hsa04714 Thermogenesis NDUFAF6 187.6323883 182.0724295 193.1923472 1.061074144 0.085525469 0.831515622 1 2.258686872 2.35652981 137682 NADH:ubiquinone oxidoreductase complex assembly factor 6 "GO:0005634,GO:0005739,GO:0005743,GO:0032981" nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I assembly hsa04714 Thermogenesis NDUFAF7 292.7840019 318.3666481 267.2013558 0.839288152 -0.25276188 0.428273759 1 4.057951487 3.348799311 55471 NADH:ubiquinone oxidoreductase complex assembly factor 7 "GO:0005515,GO:0005615,GO:0005739,GO:0005759,GO:0008168,GO:0019899,GO:0019918,GO:0032981,GO:0035243" "protein binding|extracellular space|mitochondrion|mitochondrial matrix|methyltransferase activity|enzyme binding|peptidyl-arginine methylation, to symmetrical-dimethyl arginine|mitochondrial respiratory chain complex I assembly|protein-arginine omega-N symmetric methyltransferase activity" hsa04714 Thermogenesis NDUFAF8 279.8335486 255.9418151 303.7252821 1.186696601 0.246951133 0.447973927 1 23.87962285 27.86367144 284184 NADH:ubiquinone oxidoreductase complex assembly factor 8 "GO:0005515,GO:0005739,GO:0032981" protein binding|mitochondrion|mitochondrial respiratory chain complex I assembly NDUFB1 385.6789763 359.9832034 411.3747492 1.142760955 0.192523649 0.513655319 1 60.60454872 68.09759801 4707 NADH:ubiquinone oxidoreductase subunit B1 "GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0016021,GO:0016607,GO:0032981" "mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|nuclear speck|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB10 872.1101369 841.6948311 902.5254427 1.072271576 0.100670345 0.689299341 1 66.54771284 70.16315444 4716 NADH:ubiquinone oxidoreductase subunit B10 "GO:0005515,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0032981" "protein binding|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB11 1384.106279 1288.032387 1480.180172 1.149179312 0.200603926 0.403262162 1 111.5907811 126.0919309 54539 NADH:ubiquinone oxidoreductase subunit B11 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0016021,GO:0032981" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|integral component of membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB2 601.501919 550.3789439 652.6248941 1.185773732 0.245828742 0.350857471 1 63.16712405 73.64853427 4708 NADH:ubiquinone oxidoreductase subunit B2 "GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0032981" "mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB3 640.1167339 529.5706663 750.6628016 1.417493168 0.503341782 0.05284746 1 17.83104931 24.85244114 4709 NADH:ubiquinone oxidoreductase subunit B3 "GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0016021,GO:0032981" "mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB4 1548.983541 1389.992947 1707.974134 1.228764604 0.297208564 0.212417867 1 46.33439656 55.98135196 4710 NADH:ubiquinone oxidoreductase subunit B4 "GO:0005654,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0006979,GO:0008137,GO:0016021,GO:0032981" "nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB5 869.3505863 832.3311061 906.3700665 1.088953735 0.122942661 0.624470043 1 10.57870478 11.32695316 4711 NADH:ubiquinone oxidoreductase subunit B5 "GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0016021,GO:0032981" "protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB6 572.3457926 453.6204528 691.0711324 1.523456731 0.607348526 0.022231535 0.822216713 17.7875752 26.64514278 4712 NADH:ubiquinone oxidoreductase subunit B6 "GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0016021,GO:0031966,GO:0032981,GO:0042775" "protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial membrane|mitochondrial respiratory chain complex I assembly|mitochondrial ATP synthesis coupled electron transport" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB7 622.8800934 569.1063938 676.653793 1.188975911 0.249719486 0.34006367 1 23.06162662 26.96088667 4713 NADH:ubiquinone oxidoreductase subunit B7 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0005758,GO:0006120,GO:0008137,GO:0032981" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial intermembrane space|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB8 3682.000845 3149.332823 4214.668867 1.338273566 0.420373058 0.077108271 1 176.7340742 232.5607222 4714 NADH:ubiquinone oxidoreductase subunit B8 "GO:0005739,GO:0005743,GO:0005747,GO:0005759,GO:0005783,GO:0006120,GO:0008137,GO:0016021,GO:0032981" "mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial matrix|endoplasmic reticulum|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFB9 3033.520557 2702.995267 3364.045846 1.244562241 0.315638381 0.182588089 1 208.7610557 255.4684562 4715 NADH:ubiquinone oxidoreductase subunit B9 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0007605,GO:0008137,GO:0032981" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|sensory perception of sound|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFC1 527.6073813 465.0650055 590.149757 1.268961865 0.343648714 0.203441748 1 17.99830645 22.45698204 4717 NADH:ubiquinone oxidoreductase subunit C1 "GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0016021,GO:0032981" "mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFC2 98.12661189 78.0310412 118.2221826 1.515066066 0.599380705 0.204655741 1 1.920836372 2.861495849 4718 NADH:ubiquinone oxidoreductase subunit C2 "GO:0005737,GO:0005739,GO:0005743,GO:0005747,GO:0005886,GO:0006120,GO:0008137,GO:0016021,GO:0032981,GO:0035577,GO:0043312" "cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|plasma membrane|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial respiratory chain complex I assembly|azurophil granule membrane|neutrophil degranulation" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFS1 3018.289902 2833.047002 3203.532801 1.130772909 0.177309225 0.454195648 1 12.84138879 14.2777104 4719 NADH:ubiquinone oxidoreductase core subunit S1 "GO:0005515,GO:0005739,GO:0005747,GO:0005758,GO:0005759,GO:0006120,GO:0008137,GO:0008637,GO:0009055,GO:0032981,GO:0045333,GO:0046034,GO:0046872,GO:0051537,GO:0051539,GO:0051881,GO:0072593" "protein binding|mitochondrion|mitochondrial respiratory chain complex I|mitochondrial intermembrane space|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|apoptotic mitochondrial changes|electron transfer activity|mitochondrial respiratory chain complex I assembly|cellular respiration|ATP metabolic process|metal ion binding|2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|regulation of mitochondrial membrane potential|reactive oxygen species metabolic process" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFS2 2093.053262 2047.534521 2138.572002 1.044462001 0.062760005 0.792340569 1 42.06049045 43.19546517 4720 NADH:ubiquinone oxidoreductase core subunit S2 "GO:0003954,GO:0005515,GO:0005654,GO:0005739,GO:0005747,GO:0005759,GO:0006120,GO:0006979,GO:0008137,GO:0009055,GO:0031625,GO:0032981,GO:0042775,GO:0046872,GO:0048038,GO:0051287,GO:0051539" "NADH dehydrogenase activity|protein binding|nucleoplasm|mitochondrion|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|NADH dehydrogenase (ubiquinone) activity|electron transfer activity|ubiquitin protein ligase binding|mitochondrial respiratory chain complex I assembly|mitochondrial ATP synthesis coupled electron transport|metal ion binding|quinone binding|NAD binding|4 iron, 4 sulfur cluster binding" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFS3 738.9120078 637.7737101 840.0503055 1.317160448 0.397431096 0.118025359 1 38.07249522 49.30843293 4722 NADH:ubiquinone oxidoreductase core subunit S3 "GO:0003954,GO:0005515,GO:0005739,GO:0005747,GO:0005759,GO:0006120,GO:0008137,GO:0009055,GO:0016604,GO:0021762,GO:0030308,GO:0031966,GO:0032981,GO:0072593,GO:2001243" "NADH dehydrogenase activity|protein binding|mitochondrion|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|electron transfer activity|nuclear body|substantia nigra development|negative regulation of cell growth|mitochondrial membrane|mitochondrial respiratory chain complex I assembly|reactive oxygen species metabolic process|negative regulation of intrinsic apoptotic signaling pathway" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFS4 874.6570657 782.3912397 966.9228917 1.235855979 0.305510628 0.220221625 1 43.67655072 53.07467887 4724 NADH:ubiquinone oxidoreductase subunit S4 "GO:0001932,GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0007420,GO:0008137,GO:0019933,GO:0032981,GO:0045333,GO:0048146,GO:0051591,GO:0072593" "regulation of protein phosphorylation|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|brain development|NADH dehydrogenase (ubiquinone) activity|cAMP-mediated signaling|mitochondrial respiratory chain complex I assembly|cellular respiration|positive regulation of fibroblast proliferation|response to cAMP|reactive oxygen species metabolic process" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFS5 2460.427458 2116.201837 2804.65308 1.325323998 0.406345094 0.085760147 1 230.0158913 299.7444028 4725 NADH:ubiquinone oxidoreductase subunit S5 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0005758,GO:0006120,GO:0008137,GO:0032981" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial intermembrane space|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFS6 700.7085738 631.5312268 769.8859208 1.219078152 0.285790616 0.265110305 1 65.06498237 77.99199742 4726 NADH:ubiquinone oxidoreductase subunit S6 "GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0009055,GO:0032981" "mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|electron transfer activity|mitochondrial respiratory chain complex I assembly" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFS7 455.4219193 412.0038975 498.8399412 1.210765102 0.275918998 0.324927022 1 11.57257409 13.77720256 374291 NADH:ubiquinone oxidoreductase core subunit S7 "GO:0003954,GO:0005515,GO:0005747,GO:0005759,GO:0006120,GO:0008137,GO:0009060,GO:0015990,GO:0016655,GO:0032981,GO:0046872,GO:0048038,GO:0051539" "NADH dehydrogenase activity|protein binding|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|aerobic respiration|electron transport coupled proton transport|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|mitochondrial respiratory chain complex I assembly|metal ion binding|quinone binding|4 iron, 4 sulfur cluster binding" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFS8 1412.589328 1266.183695 1558.994961 1.231254964 0.300129542 0.210066303 1 91.68778381 111.0019603 4728 NADH:ubiquinone oxidoreductase core subunit S8 "GO:0003954,GO:0005515,GO:0005739,GO:0005747,GO:0005759,GO:0006120,GO:0006979,GO:0008137,GO:0009060,GO:0032981,GO:0046872,GO:0051539" "NADH dehydrogenase activity|protein binding|mitochondrion|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|NADH dehydrogenase (ubiquinone) activity|aerobic respiration|mitochondrial respiratory chain complex I assembly|metal ion binding|4 iron, 4 sulfur cluster binding" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFV1 1987.728041 1944.533547 2030.922535 1.044426587 0.062711088 0.792717692 1 67.69483463 69.51917808 4723 NADH:ubiquinone oxidoreductase core subunit V1 "GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0005829,GO:0006120,GO:0008137,GO:0010181,GO:0032981,GO:0042775,GO:0046872,GO:0051287,GO:0051539" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|cytosol|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|FMN binding|mitochondrial respiratory chain complex I assembly|mitochondrial ATP synthesis coupled electron transport|metal ion binding|NAD binding|4 iron, 4 sulfur cluster binding" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFV2 2130.866665 1829.047606 2432.685725 1.330028654 0.411457327 0.081988904 1 80.33984285 105.0662311 4729 NADH:ubiquinone oxidoreductase core subunit V2 "GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005747,GO:0005829,GO:0006120,GO:0007399,GO:0008137,GO:0009055,GO:0032981,GO:0046872,GO:0048738,GO:0051537" "protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|cytosol|mitochondrial electron transport, NADH to ubiquinone|nervous system development|NADH dehydrogenase (ubiquinone) activity|electron transfer activity|mitochondrial respiratory chain complex I assembly|metal ion binding|cardiac muscle tissue development|2 iron, 2 sulfur cluster binding" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NDUFV3 601.4522292 574.3084632 628.5959952 1.094526784 0.130307259 0.623781127 1 5.260862882 5.661800399 4731 NADH:ubiquinone oxidoreductase subunit V3 "GO:0003723,GO:0005515,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0032981,GO:0042775" "RNA binding|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly|mitochondrial ATP synthesis coupled electron transport" "hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases NEB 5.603389465 8.323311061 2.883467868 0.346432789 -1.529352609 0.352439314 1 0.016348306 0.005568817 4703 nebulin "GO:0005515,GO:0005829,GO:0007517,GO:0007525,GO:0008307,GO:0015629,GO:0030018,GO:0030049,GO:0030832,GO:0048747,GO:0051015,GO:0070062,GO:0071691" protein binding|cytosol|muscle organ development|somatic muscle development|structural constituent of muscle|actin cytoskeleton|Z disc|muscle filament sliding|regulation of actin filament length|muscle fiber development|actin filament binding|extracellular exosome|cardiac muscle thin filament assembly NECAB2 7.68421723 12.48496659 2.883467868 0.230955193 -2.11431511 0.122989943 1 0.239331796 0.05434997 54550 N-terminal EF-hand calcium binding protein 2 "GO:0005509,GO:0005515,GO:0005737,GO:0005886,GO:0030424,GO:0030425,GO:0031687,GO:0031802,GO:0042984,GO:0060168,GO:0070374,GO:1900451,GO:1904021,GO:1905477" calcium ion binding|protein binding|cytoplasm|plasma membrane|axon|dendrite|A2A adenosine receptor binding|type 5 metabotropic glutamate receptor binding|regulation of amyloid precursor protein biosynthetic process|positive regulation of adenosine receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of glutamate receptor signaling pathway|negative regulation of G protein-coupled receptor internalization|positive regulation of protein localization to membrane NECAB3 488.7944215 480.6712138 496.9176292 1.033799435 0.047956319 0.86868401 1 12.04910251 12.24791513 63941 N-terminal EF-hand calcium binding protein 3 "GO:0000137,GO:0005509,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0009306,GO:0019538,GO:0042984" Golgi cis cisterna|calcium ion binding|protein binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein secretion|protein metabolic process|regulation of amyloid precursor protein biosynthetic process NECAP1 643.3606641 728.2897178 558.4316104 0.766771241 -0.383131868 0.139964203 1 14.75606822 11.12519542 25977 NECAP endocytosis associated 1 "GO:0005515,GO:0005829,GO:0005905,GO:0006897,GO:0015031,GO:0016192,GO:0030125,GO:0061024" protein binding|cytosol|clathrin-coated pit|endocytosis|protein transport|vesicle-mediated transport|clathrin vesicle coat|membrane organization NECAP2 1285.728031 1039.373469 1532.082594 1.474044355 0.559779936 0.020271379 0.810058917 25.5149272 36.98077974 55707 NECAP endocytosis associated 2 "GO:0005905,GO:0006897,GO:0015031,GO:0016192,GO:0030125" clathrin-coated pit|endocytosis|protein transport|vesicle-mediated transport|clathrin vesicle coat NECTIN1 114.6889457 121.7284243 107.6494671 0.884341252 -0.177324907 0.704694589 1 0.985949655 0.857325619 5818 nectin cell adhesion molecule 1 "GO:0001618,GO:0002089,GO:0002934,GO:0005515,GO:0005576,GO:0005886,GO:0005912,GO:0006826,GO:0006955,GO:0007155,GO:0007156,GO:0007157,GO:0007411,GO:0015026,GO:0016020,GO:0016021,GO:0019062,GO:0030246,GO:0030425,GO:0032584,GO:0034332,GO:0042802,GO:0042803,GO:0043231,GO:0043296,GO:0044291,GO:0044877,GO:0046718,GO:0046790,GO:0050839,GO:0051963,GO:0060041,GO:0070166,GO:0098609,GO:0098686,GO:0099059,GO:1902414" virus receptor activity|lens morphogenesis in camera-type eye|desmosome organization|protein binding|extracellular region|plasma membrane|adherens junction|iron ion transport|immune response|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|axon guidance|coreceptor activity|membrane|integral component of membrane|virion attachment to host cell|carbohydrate binding|dendrite|growth cone membrane|adherens junction organization|identical protein binding|protein homodimerization activity|intracellular membrane-bounded organelle|apical junction complex|cell-cell contact zone|protein-containing complex binding|viral entry into host cell|virion binding|cell adhesion molecule binding|regulation of synapse assembly|retina development in camera-type eye|enamel mineralization|cell-cell adhesion|hippocampal mossy fiber to CA3 synapse|integral component of presynaptic active zone membrane|protein localization to cell junction "hsa04514,hsa04520,hsa05168" Cell adhesion molecules|Adherens junction|Herpes simplex virus 1 infection NECTIN2 1389.149219 1395.195017 1383.103421 0.991333401 -0.012557755 0.961490447 1 21.8611256 21.30901804 5819 nectin cell adhesion molecule 2 "GO:0001618,GO:0001675,GO:0002860,GO:0002891,GO:0005515,GO:0005886,GO:0005911,GO:0005915,GO:0005925,GO:0007010,GO:0007156,GO:0007286,GO:0007289,GO:0009566,GO:0009986,GO:0015026,GO:0016021,GO:0019064,GO:0030382,GO:0032990,GO:0033005,GO:0034332,GO:0042271,GO:0042802,GO:0042803,GO:0043296,GO:0044291,GO:0044406,GO:0044782,GO:0045954,GO:0046596,GO:0046814,GO:0050776,GO:0050839,GO:0050862,GO:0051654,GO:0060370,GO:0070062" virus receptor activity|acrosome assembly|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of immunoglobulin mediated immune response|protein binding|plasma membrane|cell-cell junction|zonula adherens|focal adhesion|cytoskeleton organization|homophilic cell adhesion via plasma membrane adhesion molecules|spermatid development|spermatid nucleus differentiation|fertilization|cell surface|coreceptor activity|integral component of membrane|fusion of virus membrane with host plasma membrane|sperm mitochondrion organization|cell part morphogenesis|positive regulation of mast cell activation|adherens junction organization|susceptibility to natural killer cell mediated cytotoxicity|identical protein binding|protein homodimerization activity|apical junction complex|cell-cell contact zone|adhesion of symbiont to host|cilium organization|positive regulation of natural killer cell mediated cytotoxicity|regulation of viral entry into host cell|coreceptor-mediated virion attachment to host cell|regulation of immune response|cell adhesion molecule binding|positive regulation of T cell receptor signaling pathway|establishment of mitochondrion localization|susceptibility to T cell mediated cytotoxicity|extracellular exosome "hsa04514,hsa04520,hsa05168" Cell adhesion molecules|Adherens junction|Herpes simplex virus 1 infection NECTIN3 729.6709714 811.5228285 647.8191143 0.798275898 -0.325040642 0.201879136 1 5.810233678 4.56055602 25945 nectin cell adhesion molecule 3 "GO:0002089,GO:0005515,GO:0005886,GO:0005911,GO:0005912,GO:0007156,GO:0007157,GO:0007286,GO:0009566,GO:0030424,GO:0030425,GO:0034332,GO:0042803,GO:0043296,GO:0044291,GO:0050839,GO:0060042,GO:0061951,GO:0098686,GO:0099061,GO:1902414" lens morphogenesis in camera-type eye|protein binding|plasma membrane|cell-cell junction|adherens junction|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|spermatid development|fertilization|axon|dendrite|adherens junction organization|protein homodimerization activity|apical junction complex|cell-cell contact zone|cell adhesion molecule binding|retina morphogenesis in camera-type eye|establishment of protein localization to plasma membrane|hippocampal mossy fiber to CA3 synapse|integral component of postsynaptic density membrane|protein localization to cell junction "hsa04514,hsa04520" Cell adhesion molecules|Adherens junction NECTIN4 9.125951164 12.48496659 5.766935736 0.461910386 -1.11431511 0.374388992 1 0.188433179 0.085582759 81607 nectin cell adhesion molecule 4 "GO:0001618,GO:0005515,GO:0005886,GO:0005912,GO:0007156,GO:0007157,GO:0016021,GO:0034332,GO:0042802,GO:0046718,GO:0070062" virus receptor activity|protein binding|plasma membrane|adherens junction|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|integral component of membrane|adherens junction organization|identical protein binding|viral entry into host cell|extracellular exosome hsa04520 Adherens junction NEDD1 1665.965936 1584.550343 1747.381528 1.102761762 0.141121148 0.553640892 1 20.82357536 22.57918054 121441 NEDD1 gamma-tubulin ring complex targeting factor "GO:0000086,GO:0000242,GO:0000922,GO:0005515,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0010389,GO:0036064,GO:0045177,GO:0051301,GO:0071539,GO:0097711" G2/M transition of mitotic cell cycle|pericentriolar material|spindle pole|protein binding|nucleoplasm|centrosome|centriole|cytosol|plasma membrane|regulation of G2/M transition of mitotic cell cycle|ciliary basal body|apical part of cell|cell division|protein localization to centrosome|ciliary basal body-plasma membrane docking NEDD4 1432.089235 1374.386739 1489.791732 1.083968354 0.116322639 0.628373014 1 9.372411736 9.989393964 4734 NEDD4 E3 ubiquitin protein ligase "GO:0000151,GO:0000209,GO:0000785,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0005938,GO:0006511,GO:0006622,GO:0007041,GO:0007528,GO:0010766,GO:0010768,GO:0014068,GO:0016241,GO:0016327,GO:0016567,GO:0019871,GO:0019899,GO:0019904,GO:0030948,GO:0031175,GO:0031623,GO:0031698,GO:0032801,GO:0032991,GO:0034644,GO:0034765,GO:0042391,GO:0042921,GO:0043130,GO:0043161,GO:0043162,GO:0043197,GO:0044111,GO:0045732,GO:0046755,GO:0046824,GO:0048471,GO:0048814,GO:0050807,GO:0050815,GO:0050816,GO:0050847,GO:0051592,GO:0061630,GO:0070062,GO:0070063,GO:0070064,GO:0070534,GO:1901016,GO:2000650" ubiquitin ligase complex|protein polyubiquitination|chromatin|protein binding|cytoplasm|Golgi apparatus|cytosol|plasma membrane|cell cortex|ubiquitin-dependent protein catabolic process|protein targeting to lysosome|lysosomal transport|neuromuscular junction development|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|positive regulation of phosphatidylinositol 3-kinase signaling|regulation of macroautophagy|apicolateral plasma membrane|protein ubiquitination|sodium channel inhibitor activity|enzyme binding|protein domain specific binding|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|receptor internalization|beta-2 adrenergic receptor binding|receptor catabolic process|protein-containing complex|cellular response to UV|regulation of ion transmembrane transport|regulation of membrane potential|glucocorticoid receptor signaling pathway|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|dendritic spine|development involved in symbiotic interaction|positive regulation of protein catabolic process|viral budding|positive regulation of nucleocytoplasmic transport|perinuclear region of cytoplasm|regulation of dendrite morphogenesis|regulation of synapse organization|phosphoserine residue binding|phosphothreonine residue binding|progesterone receptor signaling pathway|response to calcium ion|ubiquitin protein ligase activity|extracellular exosome|RNA polymerase binding|proline-rich region binding|protein K63-linked ubiquitination|regulation of potassium ion transmembrane transporter activity|negative regulation of sodium ion transmembrane transporter activity "hsa04120,hsa04144,hsa04530,hsa05169" Ubiquitin mediated proteolysis|Endocytosis|Tight junction|Epstein-Barr virus infection NEDD4L 5660.646365 5271.777143 6049.515587 1.147528703 0.19853024 0.410995585 1 24.19548134 27.30039949 23327 NEDD4 like E3 ubiquitin protein ligase "GO:0000122,GO:0000209,GO:0003254,GO:0004842,GO:0005515,GO:0005654,GO:0005737,GO:0005771,GO:0005794,GO:0005829,GO:0005886,GO:0006511,GO:0006814,GO:0006883,GO:0007588,GO:0010038,GO:0015459,GO:0016567,GO:0017080,GO:0019058,GO:0019870,GO:0019871,GO:0030104,GO:0030154,GO:0031647,GO:0034220,GO:0034765,GO:0042176,GO:0042391,GO:0043161,GO:0044325,GO:0045732,GO:0045807,GO:0048814,GO:0060306,GO:0061630,GO:0070062,GO:0070936,GO:0086005,GO:1901016,GO:1901017,GO:1901380,GO:1902306,GO:1903861,GO:2000009,GO:2000650,GO:2001288" negative regulation of transcription by RNA polymerase II|protein polyubiquitination|regulation of membrane depolarization|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytoplasm|multivesicular body|Golgi apparatus|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|sodium ion transport|cellular sodium ion homeostasis|excretion|response to metal ion|potassium channel regulator activity|protein ubiquitination|sodium channel regulator activity|viral life cycle|potassium channel inhibitor activity|sodium channel inhibitor activity|water homeostasis|cell differentiation|regulation of protein stability|ion transmembrane transport|regulation of ion transmembrane transport|regulation of protein catabolic process|regulation of membrane potential|proteasome-mediated ubiquitin-dependent protein catabolic process|ion channel binding|positive regulation of protein catabolic process|positive regulation of endocytosis|regulation of dendrite morphogenesis|regulation of membrane repolarization|ubiquitin protein ligase activity|extracellular exosome|protein K48-linked ubiquitination|ventricular cardiac muscle cell action potential|regulation of potassium ion transmembrane transporter activity|negative regulation of potassium ion transmembrane transporter activity|negative regulation of potassium ion transmembrane transport|negative regulation of sodium ion transmembrane transport|positive regulation of dendrite extension|negative regulation of protein localization to cell surface|negative regulation of sodium ion transmembrane transporter activity|positive regulation of caveolin-mediated endocytosis "hsa04120,hsa04144,hsa04530,hsa04960" Ubiquitin mediated proteolysis|Endocytosis|Tight junction|Aldosterone-regulated sodium reabsorption NEDD8 588.2690325 493.1561804 683.3818847 1.385731158 0.470647391 0.074606539 1 42.72538793 58.2151707 4738 NEDD8 ubiquitin like modifier "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006464,GO:0006508,GO:0006511,GO:0006879,GO:0008104,GO:0009653,GO:0014070,GO:0016567,GO:0016579,GO:0019941,GO:0030162,GO:0031386,GO:0031625,GO:0043687,GO:0045116,GO:0070062" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|cellular protein modification process|proteolysis|ubiquitin-dependent protein catabolic process|cellular iron ion homeostasis|protein localization|anatomical structure morphogenesis|response to organic cyclic compound|protein ubiquitination|protein deubiquitination|modification-dependent protein catabolic process|regulation of proteolysis|protein tag|ubiquitin protein ligase binding|post-translational protein modification|protein neddylation|extracellular exosome NEDD9 32.74346918 39.53572754 25.95121081 0.656398969 -0.607355121 0.396964861 1 0.277734516 0.179254028 4739 "neural precursor cell expressed, developmentally down-regulated 9" "GO:0000922,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005819,GO:0005829,GO:0005886,GO:0005925,GO:0005938,GO:0007010,GO:0007049,GO:0007155,GO:0007165,GO:0007169,GO:0007229,GO:0016477,GO:0030027,GO:0030335,GO:0040008,GO:0051017,GO:0051301,GO:0061098,GO:0090527,GO:0090630,GO:1900026,GO:1990782" spindle pole|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|spindle|cytosol|plasma membrane|focal adhesion|cell cortex|cytoskeleton organization|cell cycle|cell adhesion|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|integrin-mediated signaling pathway|cell migration|lamellipodium|positive regulation of cell migration|regulation of growth|actin filament bundle assembly|cell division|positive regulation of protein tyrosine kinase activity|actin filament reorganization|activation of GTPase activity|positive regulation of substrate adhesion-dependent cell spreading|protein tyrosine kinase binding NEGR1 625.2131718 642.9757795 607.4505642 0.94474875 -0.08199739 0.758216949 1 2.114911286 1.96462497 257194 neuronal growth regulator 1 "GO:0005515,GO:0005576,GO:0005886,GO:0007626,GO:0007631,GO:0010976,GO:0031225,GO:0098609" protein binding|extracellular region|plasma membrane|locomotory behavior|feeding behavior|positive regulation of neuron projection development|anchored component of membrane|cell-cell adhesion hsa04514 Cell adhesion molecules NEIL1 54.36444777 52.02069413 56.7082014 1.090108511 0.12447175 0.860701416 1 0.813910535 0.872403861 79661 nei like DNA glycosylase 1 "GO:0003684,GO:0003906,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005815,GO:0006284,GO:0006979,GO:0008022,GO:0008270,GO:0016798,GO:0019104,GO:0032074,GO:0045008,GO:0140078" "damaged DNA binding|DNA-(apurinic or apyrimidinic site) endonuclease activity|nucleus|nucleoplasm|chromosome|cytoplasm|microtubule organizing center|base-excision repair|response to oxidative stress|protein C-terminus binding|zinc ion binding|hydrolase activity, acting on glycosyl bonds|DNA N-glycosylase activity|negative regulation of nuclease activity|depyrimidination|class I DNA-(apurinic or apyrimidinic site) endonuclease activity" hsa03410 Base excision repair NEIL2 226.821516 226.8102264 226.8328056 1.000099551 0.000143615 1 1 5.224188573 5.137280223 252969 nei like DNA glycosylase 2 "GO:0003684,GO:0003906,GO:0005515,GO:0005654,GO:0005737,GO:0006284,GO:0008017,GO:0008270,GO:0019104,GO:0043231,GO:0045008,GO:0072686,GO:0140078" damaged DNA binding|DNA-(apurinic or apyrimidinic site) endonuclease activity|protein binding|nucleoplasm|cytoplasm|base-excision repair|microtubule binding|zinc ion binding|DNA N-glycosylase activity|intracellular membrane-bounded organelle|depyrimidination|mitotic spindle|class I DNA-(apurinic or apyrimidinic site) endonuclease activity hsa03410 Base excision repair NEIL3 743.3749894 792.7953786 693.9546002 0.875326243 -0.192107271 0.451033109 1 17.88251575 15.39110298 55247 nei like DNA glycosylase 3 "GO:0000405,GO:0003684,GO:0003690,GO:0003697,GO:0003906,GO:0005634,GO:0005654,GO:0005694,GO:0006284,GO:0008270,GO:0019104,GO:0036297,GO:0140078,GO:1904931" bubble DNA binding|damaged DNA binding|double-stranded DNA binding|single-stranded DNA binding|DNA-(apurinic or apyrimidinic site) endonuclease activity|nucleus|nucleoplasm|chromosome|base-excision repair|zinc ion binding|DNA N-glycosylase activity|interstrand cross-link repair|class I DNA-(apurinic or apyrimidinic site) endonuclease activity|MCM complex binding hsa03410 Base excision repair NEK1 547.0085235 520.2069413 573.8101057 1.103042001 0.141487727 0.601195812 1 2.98425114 3.2366713 4750 NIMA related kinase 1 "GO:0000242,GO:0004672,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006468,GO:0007049,GO:0016301,GO:0018108,GO:0034451,GO:0042769,GO:0046872,GO:0051301,GO:0060271,GO:0071889,GO:0106310,GO:0106311" "pericentriolar material|protein kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|protein phosphorylation|cell cycle|kinase activity|peptidyl-tyrosine phosphorylation|centriolar satellite|DNA damage response, detection of DNA damage|metal ion binding|cell division|cilium assembly|14-3-3 protein binding|protein serine kinase activity|protein threonine kinase activity" NEK10 18.73248031 24.96993318 12.49502743 0.500402918 -0.998837892 0.259562808 1 0.069861045 0.034373685 152110 NIMA related kinase 10 "GO:0004672,GO:0004674,GO:0005524,GO:0005576,GO:0006468,GO:0031954,GO:0043406,GO:0046872,GO:0070372,GO:0106310,GO:0106311,GO:0120197,GO:1902749,GO:1902911" protein kinase activity|protein serine/threonine kinase activity|ATP binding|extracellular region|protein phosphorylation|positive regulation of protein autophosphorylation|positive regulation of MAP kinase activity|metal ion binding|regulation of ERK1 and ERK2 cascade|protein serine kinase activity|protein threonine kinase activity|mucociliary clearance|regulation of cell cycle G2/M phase transition|protein kinase complex NEK11 74.70220828 68.66731625 80.7371003 1.175771891 0.233608194 0.669429111 1 0.583542749 0.674631987 79858 NIMA related kinase 11 "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0006468,GO:0007059,GO:0016572,GO:0031573,GO:0035556,GO:0046872,GO:0106310,GO:0106311,GO:1901990" protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|protein phosphorylation|chromosome segregation|histone phosphorylation|intra-S DNA damage checkpoint|intracellular signal transduction|metal ion binding|protein serine kinase activity|protein threonine kinase activity|regulation of mitotic cell cycle phase transition NEK2 1670.457257 1967.422652 1373.491861 0.698117336 -0.518458557 0.029227134 0.88444427 32.01150335 21.97382552 4751 NIMA related kinase 2 "GO:0000070,GO:0000086,GO:0000278,GO:0000776,GO:0000777,GO:0000794,GO:0000922,GO:0001824,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0005874,GO:0006468,GO:0007059,GO:0007088,GO:0010389,GO:0019903,GO:0030496,GO:0032212,GO:0032991,GO:0043392,GO:0046602,GO:0046777,GO:0046872,GO:0051225,GO:0051299,GO:0051301,GO:0051321,GO:0051973,GO:0051988,GO:0090307,GO:0097711,GO:0106310,GO:0106311,GO:1903126,GO:1904355" mitotic sister chromatid segregation|G2/M transition of mitotic cell cycle|mitotic cell cycle|kinetochore|condensed chromosome kinetochore|condensed nuclear chromosome|spindle pole|blastocyst development|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|cytosol|microtubule|protein phosphorylation|chromosome segregation|regulation of mitotic nuclear division|regulation of G2/M transition of mitotic cell cycle|protein phosphatase binding|midbody|positive regulation of telomere maintenance via telomerase|protein-containing complex|negative regulation of DNA binding|regulation of mitotic centrosome separation|protein autophosphorylation|metal ion binding|spindle assembly|centrosome separation|cell division|meiotic cell cycle|positive regulation of telomerase activity|regulation of attachment of spindle microtubules to kinetochore|mitotic spindle assembly|ciliary basal body-plasma membrane docking|protein serine kinase activity|protein threonine kinase activity|negative regulation of centriole-centriole cohesion|positive regulation of telomere capping NEK3 460.1138427 396.3976893 523.829996 1.321475907 0.402150122 0.149345749 1 8.866310197 11.52055362 4752 NIMA related kinase 3 "GO:0000278,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0030424,GO:0046872,GO:0051301,GO:0106310,GO:0106311" mitotic cell cycle|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|axon|metal ion binding|cell division|protein serine kinase activity|protein threonine kinase activity NEK4 574.242338 616.9654324 531.5192437 0.861505711 -0.215067734 0.419105033 1 3.796853228 3.216274806 6787 NIMA related kinase 4 "GO:0000278,GO:0004674,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0006974,GO:0030145,GO:0035253,GO:0035869,GO:0036064,GO:0045893,GO:0051301,GO:0097014,GO:0106310,GO:0106311,GO:2000772,GO:2001020" "mitotic cell cycle|protein serine/threonine kinase activity|ATP binding|cytoplasm|cytosol|protein phosphorylation|cellular response to DNA damage stimulus|manganese ion binding|ciliary rootlet|ciliary transition zone|ciliary basal body|positive regulation of transcription, DNA-templated|cell division|ciliary plasm|protein serine kinase activity|protein threonine kinase activity|regulation of cellular senescence|regulation of response to DNA damage stimulus" NEK5 3.601819626 6.242483296 0.961155956 0.153970129 -2.699277611 0.237188726 1 0.04000839 0.006057016 341676 NIMA related kinase 5 "GO:0005524,GO:0006468,GO:0046872,GO:0106310,GO:0106311" ATP binding|protein phosphorylation|metal ion binding|protein serine kinase activity|protein threonine kinase activity NEK6 1433.311474 1620.964829 1245.658119 0.768467086 -0.379944625 0.112161699 1 19.35300083 14.62327897 10783 NIMA related kinase 6 "GO:0000287,GO:0000922,GO:0001222,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005874,GO:0006468,GO:0006915,GO:0007059,GO:0007077,GO:0007346,GO:0016607,GO:0018105,GO:0019894,GO:0019901,GO:0030071,GO:0031625,GO:0032991,GO:0033613,GO:0034451,GO:0043123,GO:0046777,GO:0051225,GO:0051301,GO:0106310,GO:0106311,GO:2000772" magnesium ion binding|spindle pole|transcription corepressor binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|microtubule|protein phosphorylation|apoptotic process|chromosome segregation|mitotic nuclear envelope disassembly|regulation of mitotic cell cycle|nuclear speck|peptidyl-serine phosphorylation|kinesin binding|protein kinase binding|regulation of mitotic metaphase/anaphase transition|ubiquitin protein ligase binding|protein-containing complex|activating transcription factor binding|centriolar satellite|positive regulation of I-kappaB kinase/NF-kappaB signaling|protein autophosphorylation|spindle assembly|cell division|protein serine kinase activity|protein threonine kinase activity|regulation of cellular senescence NEK7 1577.093608 1598.075724 1556.111493 0.973740774 -0.03839034 0.874443933 1 17.48387951 16.73987996 140609 NIMA related kinase 7 "GO:0000922,GO:0004674,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005815,GO:0005874,GO:0006468,GO:0007346,GO:0032212,GO:0046872,GO:0051225,GO:0051973,GO:0106310,GO:0106311,GO:1904355" spindle pole|protein serine/threonine kinase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|microtubule organizing center|microtubule|protein phosphorylation|regulation of mitotic cell cycle|positive regulation of telomere maintenance via telomerase|metal ion binding|spindle assembly|positive regulation of telomerase activity|protein serine kinase activity|protein threonine kinase activity|positive regulation of telomere capping hsa04621 NOD-like receptor signaling pathway NEK8 37.26681579 44.73779695 29.79583464 0.666010324 -0.586383554 0.389211295 1 0.6682267 0.437598641 284086 NIMA related kinase 8 "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005929,GO:0006468,GO:0007059,GO:0007368,GO:0007507,GO:0009887,GO:0035330,GO:0046872,GO:0097543,GO:0097546,GO:0106310,GO:0106311" protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|centrosome|cilium|protein phosphorylation|chromosome segregation|determination of left/right symmetry|heart development|animal organ morphogenesis|regulation of hippo signaling|metal ion binding|ciliary inversin compartment|ciliary base|protein serine kinase activity|protein threonine kinase activity NEK9 1962.727311 2070.423626 1855.030995 0.895966879 -0.158482693 0.503760143 1 12.49516043 11.00791255 91754 NIMA related kinase 9 "GO:0005515,GO:0005524,GO:0005634,GO:0005813,GO:0005829,GO:0006468,GO:0007077,GO:0019901,GO:0046872,GO:0051301,GO:0106310,GO:0106311" protein binding|ATP binding|nucleus|centrosome|cytosol|protein phosphorylation|mitotic nuclear envelope disassembly|protein kinase binding|metal ion binding|cell division|protein serine kinase activity|protein threonine kinase activity NELFA 763.7970383 799.0378619 728.5562146 0.911791855 -0.133223572 0.601359533 1 15.84070658 14.20173605 7469 negative elongation factor complex member A "GO:0005515,GO:0005654,GO:0005829,GO:0006366,GO:0006368,GO:0007275,GO:0016604,GO:0032021,GO:0034244,GO:0050434" protein binding|nucleoplasm|cytosol|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|multicellular organism development|nuclear body|NELF complex|negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of viral transcription NELFB 1794.596673 1693.793801 1895.399545 1.119026144 0.162243742 0.494561473 1 35.58844964 39.15799807 25920 negative elongation factor complex member B "GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0006366,GO:0006368,GO:0008283,GO:0032021,GO:0034244,GO:0048863,GO:0050434,GO:2000737" RNA binding|protein binding|nucleoplasm|cytoplasm|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|cell population proliferation|NELF complex|negative regulation of transcription elongation from RNA polymerase II promoter|stem cell differentiation|positive regulation of viral transcription|negative regulation of stem cell differentiation NELFCD 1813.28388 1831.128433 1795.439326 0.980509774 -0.028396084 0.90697652 1 43.68527448 42.11707232 51497 negative elongation factor complex member C/D "GO:0003723,GO:0005515,GO:0005654,GO:0006366,GO:0006368,GO:0016020,GO:0032021,GO:0034244,GO:0050434" RNA binding|protein binding|nucleoplasm|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|membrane|NELF complex|negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of viral transcription NELFE 1353.726686 1146.536099 1560.917273 1.361420085 0.445112299 0.06376817 1 40.95617426 54.82551427 7936 negative elongation factor complex member E "GO:0000122,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0006366,GO:0006368,GO:0016604,GO:0032021,GO:0034244,GO:0045944,GO:0050434,GO:0051571,GO:0070374,GO:1900364" negative regulation of transcription by RNA polymerase II|chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|plasma membrane|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|nuclear body|NELF complex|negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription by RNA polymerase II|positive regulation of viral transcription|positive regulation of histone H3-K4 methylation|positive regulation of ERK1 and ERK2 cascade|negative regulation of mRNA polyadenylation NELL2 66.65126954 71.7885579 61.51398118 0.856877238 -0.222839567 0.699056294 1 0.876710159 0.738662112 4753 neural EGFL like 2 "GO:0005080,GO:0005509,GO:0005515,GO:0005576,GO:0005737,GO:0008201,GO:0070050" protein kinase C binding|calcium ion binding|protein binding|extracellular region|cytoplasm|heparin binding|neuron cellular homeostasis NEMF 976.8503696 1005.039811 948.6609286 0.943903832 -0.083288214 0.7383796 1 8.845172742 8.209283364 9147 nuclear export mediator factor "GO:0000049,GO:0005634,GO:0043023,GO:0051168,GO:0072344,GO:1990112,GO:1990116" tRNA binding|nucleus|ribosomal large subunit binding|nuclear export|rescue of stalled ribosome|RQC complex|ribosome-associated ubiquitin-dependent protein catabolic process NEMP1 2750.390316 2776.864653 2723.915979 0.980932209 -0.027774657 0.908034246 1 21.72645695 20.95555093 23306 nuclear envelope integral membrane protein 1 "GO:0003674,GO:0005635,GO:0005637,GO:0016021,GO:0071763" molecular_function|nuclear envelope|nuclear inner membrane|integral component of membrane|nuclear membrane organization NEMP2 815.0804877 744.93634 885.2246355 1.188322529 0.248926459 0.322172478 1 4.374547021 5.111385051 100131211 nuclear envelope integral membrane protein 2 "GO:0005635,GO:0005637,GO:0016021" nuclear envelope|nuclear inner membrane|integral component of membrane NENF 793.7570335 689.7944042 897.7196629 1.30143077 0.38009857 0.131322042 1 40.18892965 51.42788798 29937 neudesin neurotrophic factor "GO:0005515,GO:0005615,GO:0005739,GO:0005783,GO:0007165,GO:0008083,GO:0012505,GO:0016020,GO:0032099,GO:0043410,GO:0046872,GO:1901215" protein binding|extracellular space|mitochondrion|endoplasmic reticulum|signal transduction|growth factor activity|endomembrane system|membrane|negative regulation of appetite|positive regulation of MAPK cascade|metal ion binding|negative regulation of neuron death NEO1 1057.308838 1199.597207 915.0204701 0.762773092 -0.390674144 0.110167953 1 11.25532668 8.441597624 4756 neogenin 1 "GO:0005515,GO:0005654,GO:0005794,GO:0005886,GO:0005887,GO:0007155,GO:0007411,GO:0030513,GO:0038023,GO:0039706,GO:0055072,GO:0098797" protein binding|nucleoplasm|Golgi apparatus|plasma membrane|integral component of plasma membrane|cell adhesion|axon guidance|positive regulation of BMP signaling pathway|signaling receptor activity|co-receptor binding|iron ion homeostasis|plasma membrane protein complex "hsa04350,hsa04360,hsa04514" TGF-beta signaling pathway|Axon guidance|Cell adhesion molecules NEPRO 1024.006148 1057.060505 990.9517906 0.937459858 -0.093171179 0.706812312 1 11.51293395 10.61230863 25871 nucleolus and neural progenitor protein "GO:0005634,GO:0005730,GO:0007275,GO:0045665,GO:0045747" nucleus|nucleolus|multicellular organism development|negative regulation of neuron differentiation|positive regulation of Notch signaling pathway NES 78.5468321 68.66731625 88.42634795 1.287750167 0.364852727 0.483373695 1 0.65816244 0.83336621 10763 nestin "GO:0000086,GO:0003674,GO:0005515,GO:0005737,GO:0005882,GO:0007417,GO:0007420,GO:0019215,GO:0030844,GO:0031076,GO:0031730,GO:0032091,GO:0043086,GO:0043524,GO:0045111,GO:0048858,GO:0072089,GO:2000179" G2/M transition of mitotic cell cycle|molecular_function|protein binding|cytoplasm|intermediate filament|central nervous system development|brain development|intermediate filament binding|positive regulation of intermediate filament depolymerization|embryonic camera-type eye development|CCR5 chemokine receptor binding|negative regulation of protein binding|negative regulation of catalytic activity|negative regulation of neuron apoptotic process|intermediate filament cytoskeleton|cell projection morphogenesis|stem cell proliferation|positive regulation of neural precursor cell proliferation NET1 3118.601752 2854.895694 3382.307809 1.184739539 0.244569923 0.301915881 1 21.48040831 25.02283969 10276 neuroepithelial cell transforming 1 "GO:0001558,GO:0005515,GO:0005634,GO:0005829,GO:0007165,GO:0007186,GO:0035025,GO:0035556,GO:0043065,GO:0043547,GO:0051056,GO:0051451,GO:0070301,GO:0071479" regulation of cell growth|protein binding|nucleus|cytosol|signal transduction|G protein-coupled receptor signaling pathway|positive regulation of Rho protein signal transduction|intracellular signal transduction|positive regulation of apoptotic process|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|myoblast migration|cellular response to hydrogen peroxide|cellular response to ionizing radiation NETO1 562.9908997 611.763363 514.2184365 0.840551212 -0.250592373 0.347746736 1 2.483356379 2.0524586 81832 neuropilin and tolloid like 1 "GO:0005576,GO:0007613,GO:0008542,GO:0014069,GO:0035255,GO:0048169,GO:0060076,GO:0097120,GO:0098839,GO:0098978,GO:0099061,GO:2000312,GO:2000463" extracellular region|memory|visual learning|postsynaptic density|ionotropic glutamate receptor binding|regulation of long-term neuronal synaptic plasticity|excitatory synapse|receptor localization to synapse|postsynaptic density membrane|glutamatergic synapse|integral component of postsynaptic density membrane|regulation of kainate selective glutamate receptor activity|positive regulation of excitatory postsynaptic potential NETO2 1532.904358 1737.491184 1328.317531 0.764503178 -0.387405597 0.104145665 1 12.03773999 9.048892562 81831 neuropilin and tolloid like 2 "GO:0014069,GO:0016021,GO:0035255,GO:2000312" postsynaptic density|integral component of membrane|ionotropic glutamate receptor binding|regulation of kainate selective glutamate receptor activity NEU1 646.8631042 782.3912397 511.3349686 0.653554057 -0.613621526 0.018052803 0.773499658 12.45296227 8.002494153 4758 neuraminidase 1 "GO:0004308,GO:0005515,GO:0005576,GO:0005737,GO:0005764,GO:0005765,GO:0005886,GO:0006687,GO:0006689,GO:0009313,GO:0016020,GO:0016997,GO:0030054,GO:0035580,GO:0043202,GO:0043231,GO:0043312,GO:0052794,GO:0052795,GO:0052796,GO:0070062" exo-alpha-sialidase activity|protein binding|extracellular region|cytoplasm|lysosome|lysosomal membrane|plasma membrane|glycosphingolipid metabolic process|ganglioside catabolic process|oligosaccharide catabolic process|membrane|alpha-sialidase activity|cell junction|specific granule lumen|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|exo-alpha-(2->3)-sialidase activity|exo-alpha-(2->6)-sialidase activity|exo-alpha-(2->8)-sialidase activity|extracellular exosome "hsa00511,hsa00600,hsa04142" Other glycan degradation|Sphingolipid metabolism|Lysosome NEU3 595.1946547 599.2783964 591.1109129 0.986371136 -0.019797511 0.946959515 1 4.826801477 4.681348476 10825 neuraminidase 3 "GO:0004308,GO:0005515,GO:0005737,GO:0005765,GO:0005886,GO:0005901,GO:0005975,GO:0006687,GO:0006689,GO:0009313,GO:0009897,GO:0016020,GO:0016997,GO:0031901,GO:0043231,GO:0045742,GO:0052794,GO:0052795,GO:0052796,GO:0055038,GO:1900186" exo-alpha-sialidase activity|protein binding|cytoplasm|lysosomal membrane|plasma membrane|caveola|carbohydrate metabolic process|glycosphingolipid metabolic process|ganglioside catabolic process|oligosaccharide catabolic process|external side of plasma membrane|membrane|alpha-sialidase activity|early endosome membrane|intracellular membrane-bounded organelle|positive regulation of epidermal growth factor receptor signaling pathway|exo-alpha-(2->3)-sialidase activity|exo-alpha-(2->6)-sialidase activity|exo-alpha-(2->8)-sialidase activity|recycling endosome membrane|negative regulation of clathrin-dependent endocytosis "hsa00511,hsa00600" Other glycan degradation|Sphingolipid metabolism NEURL1 797.4035126 684.5923348 910.2146903 1.32957184 0.410961732 0.102593142 1 4.896198697 6.400914423 9148 neuralized E3 ubiquitin protein ligase 1 "GO:0004842,GO:0005886,GO:0006417,GO:0006513,GO:0007219,GO:0007288,GO:0007399,GO:0007420,GO:0007519,GO:0007595,GO:0008285,GO:0014069,GO:0043065,GO:0043197,GO:0043204,GO:0045183,GO:0045741,GO:0045746,GO:0046872,GO:0048170,GO:0048471,GO:0051491,GO:0060999,GO:0061630,GO:0071230,GO:0090129,GO:0097440" "ubiquitin-protein transferase activity|plasma membrane|regulation of translation|protein monoubiquitination|Notch signaling pathway|sperm axoneme assembly|nervous system development|brain development|skeletal muscle tissue development|lactation|negative regulation of cell population proliferation|postsynaptic density|positive regulation of apoptotic process|dendritic spine|perikaryon|translation factor activity, non-nucleic acid binding|positive regulation of epidermal growth factor-activated receptor activity|negative regulation of Notch signaling pathway|metal ion binding|positive regulation of long-term neuronal synaptic plasticity|perinuclear region of cytoplasm|positive regulation of filopodium assembly|positive regulation of dendritic spine development|ubiquitin protein ligase activity|cellular response to amino acid stimulus|positive regulation of synapse maturation|apical dendrite" NEURL1B 665.7704203 572.2276355 759.3132052 1.326942563 0.408105925 0.114026529 1 4.75163174 6.199634381 54492 neuralized E3 ubiquitin protein ligase 1B "GO:0005515,GO:0005769,GO:0005829,GO:0007219,GO:0015629,GO:0016567,GO:0046872,GO:0061630,GO:0070086" protein binding|early endosome|cytosol|Notch signaling pathway|actin cytoskeleton|protein ubiquitination|metal ion binding|ubiquitin protein ligase activity|ubiquitin-dependent endocytosis NEURL2 8.164795208 12.48496659 3.844623824 0.307940257 -1.699277611 0.194385442 1 0.549299028 0.166320766 140825 neuralized E3 ubiquitin protein ligase 2 "GO:0005829,GO:0016567,GO:0035556,GO:0043687,GO:0061630" cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification|ubiquitin protein ligase activity NEURL3 25.01459256 38.49531366 11.53387147 0.299617548 -1.738805975 0.028563801 0.881738096 0.983448606 0.289727749 93082 neuralized E3 ubiquitin protein ligase 3 "GO:0016567,GO:0046872,GO:0061630" protein ubiquitination|metal ion binding|ubiquitin protein ligase activity NEURL4 544.9522335 554.5405994 535.3638675 0.965418705 -0.050773315 0.85627597 1 5.683659034 5.395291378 84461 neuralized E3 ubiquitin protein ligase 4 "GO:0005515,GO:0005737,GO:0005814,GO:0016567,GO:0061630" protein binding|cytoplasm|centriole|protein ubiquitination|ubiquitin protein ligase activity NEUROG2 3.522561699 4.161655531 2.883467868 0.692865579 -0.529352609 0.940314863 1 0.096775559 0.065930421 63973 neurogenin 2 "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0030182,GO:0046983,GO:0051091,GO:0070888,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|neuron differentiation|protein dimerization activity|positive regulation of DNA-binding transcription factor activity|E-box binding|sequence-specific double-stranded DNA binding" bHLH NEXN 174.3001222 172.7087045 175.8915399 1.018428923 0.026345297 0.96173276 1 1.134278382 1.135851507 91624 nexilin F-actin binding protein "GO:0005886,GO:0005912,GO:0005925,GO:0007156,GO:0007411,GO:0008307,GO:0015629,GO:0030018,GO:0030334,GO:0030424,GO:0051015,GO:0051493,GO:0070593,GO:0098632" plasma membrane|adherens junction|focal adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|axon guidance|structural constituent of muscle|actin cytoskeleton|Z disc|regulation of cell migration|axon|actin filament binding|regulation of cytoskeleton organization|dendrite self-avoidance|cell-cell adhesion mediator activity NF1 3444.473979 3549.892168 3339.055791 0.940607667 -0.088335003 0.710394251 1 14.28957766 13.21597128 4763 neurofibromin 1 "GO:0000165,GO:0001649,GO:0001656,GO:0001666,GO:0001889,GO:0001937,GO:0001952,GO:0005096,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0006469,GO:0007154,GO:0007265,GO:0007406,GO:0007420,GO:0007422,GO:0007507,GO:0008429,GO:0008542,GO:0014044,GO:0014065,GO:0016020,GO:0021510,GO:0021897,GO:0021987,GO:0022011,GO:0030036,GO:0030198,GO:0030199,GO:0030325,GO:0030336,GO:0030424,GO:0030425,GO:0031210,GO:0042060,GO:0043065,GO:0043087,GO:0043407,GO:0043409,GO:0043473,GO:0043525,GO:0043535,GO:0043547,GO:0045124,GO:0045685,GO:0045762,GO:0045765,GO:0048147,GO:0048485,GO:0048593,GO:0048715,GO:0048745,GO:0048844,GO:0048853,GO:0050890" MAPK cascade|osteoblast differentiation|metanephros development|response to hypoxia|liver development|negative regulation of endothelial cell proliferation|regulation of cell-matrix adhesion|GTPase activator activity|protein binding|nucleus|nucleolus|cytoplasm|cytosol|negative regulation of protein kinase activity|cell communication|Ras protein signal transduction|negative regulation of neuroblast proliferation|brain development|peripheral nervous system development|heart development|phosphatidylethanolamine binding|visual learning|Schwann cell development|phosphatidylinositol 3-kinase signaling|membrane|spinal cord development|forebrain astrocyte development|cerebral cortex development|myelination in peripheral nervous system|actin cytoskeleton organization|extracellular matrix organization|collagen fibril organization|adrenal gland development|negative regulation of cell migration|axon|dendrite|phosphatidylcholine binding|wound healing|positive regulation of apoptotic process|regulation of GTPase activity|negative regulation of MAP kinase activity|negative regulation of MAPK cascade|pigmentation|positive regulation of neuron apoptotic process|regulation of blood vessel endothelial cell migration|positive regulation of GTPase activity|regulation of bone resorption|regulation of glial cell differentiation|positive regulation of adenylate cyclase activity|regulation of angiogenesis|negative regulation of fibroblast proliferation|sympathetic nervous system development|camera-type eye morphogenesis|negative regulation of oligodendrocyte differentiation|smooth muscle tissue development|artery morphogenesis|forebrain morphogenesis|cognition "hsa01521,hsa04010,hsa04014" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway NF2 1881.719681 1747.895323 2015.54404 1.153126285 0.205550519 0.385881305 1 13.99159455 15.86409354 4771 neurofibromin 2 "GO:0001707,GO:0001953,GO:0003779,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005769,GO:0005829,GO:0005856,GO:0005886,GO:0005912,GO:0006469,GO:0007398,GO:0008285,GO:0014010,GO:0014013,GO:0016020,GO:0021766,GO:0022408,GO:0030027,GO:0030036,GO:0030336,GO:0030864,GO:0031527,GO:0031647,GO:0032154,GO:0032587,GO:0035330,GO:0042475,GO:0042532,GO:0042981,GO:0043005,GO:0043409,GO:0044297,GO:0045177,GO:0045216,GO:0045597,GO:0046426,GO:0048471,GO:0051496,GO:0051726,GO:0070306,GO:0072091,GO:1900180,GO:2000177" mesoderm formation|negative regulation of cell-matrix adhesion|actin binding|protein binding|nucleus|nucleolus|cytoplasm|early endosome|cytosol|cytoskeleton|plasma membrane|adherens junction|negative regulation of protein kinase activity|ectoderm development|negative regulation of cell population proliferation|Schwann cell proliferation|regulation of gliogenesis|membrane|hippocampus development|negative regulation of cell-cell adhesion|lamellipodium|actin cytoskeleton organization|negative regulation of cell migration|cortical actin cytoskeleton|filopodium membrane|regulation of protein stability|cleavage furrow|ruffle membrane|regulation of hippo signaling|odontogenesis of dentin-containing tooth|negative regulation of tyrosine phosphorylation of STAT protein|regulation of apoptotic process|neuron projection|negative regulation of MAPK cascade|cell body|apical part of cell|cell-cell junction organization|positive regulation of cell differentiation|negative regulation of receptor signaling pathway via JAK-STAT|perinuclear region of cytoplasm|positive regulation of stress fiber assembly|regulation of cell cycle|lens fiber cell differentiation|regulation of stem cell proliferation|regulation of protein localization to nucleus|regulation of neural precursor cell proliferation "hsa04390,hsa04392,hsa04530" Hippo signaling pathway|Hippo signaling pathway - multiple species|Tight junction NFAT5 1096.259578 1339.012667 853.5064889 0.637414798 -0.649695582 0.007815263 0.544463388 7.759870239 4.863487225 10725 nuclear factor of activated T cells 5 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001816,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006357,GO:0006366,GO:0006970,GO:0007165,GO:0007588,GO:0008134,GO:0033173,GO:0045944,GO:0070884,GO:0071345,GO:1901224,GO:1904996,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|cytokine production|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|response to osmotic stress|signal transduction|excretion|transcription factor binding|calcineurin-NFAT signaling cascade|positive regulation of transcription by RNA polymerase II|regulation of calcineurin-NFAT signaling cascade|cellular response to cytokine stimulus|positive regulation of NIK/NF-kappaB signaling|positive regulation of leukocyte adhesion to vascular endothelial cell|sequence-specific double-stranded DNA binding" RHD NFATC1 67.41428068 66.58648849 68.24207288 1.024863669 0.03543201 0.978581574 1 0.474635837 0.47829716 4772 nuclear factor of activated T cells 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001085,GO:0001225,GO:0001228,GO:0001816,GO:0003180,GO:0003184,GO:0003700,GO:0005515,GO:0005528,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006357,GO:0007223,GO:0008134,GO:0016604,GO:0030178,GO:0033173,GO:0035556,GO:0038095,GO:0045893,GO:0045944,GO:0048273,GO:1905064,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|RNA polymerase II transcription coactivator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|cytokine production|aortic valve morphogenesis|pulmonary valve morphogenesis|DNA-binding transcription factor activity|protein binding|FK506 binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|Wnt signaling pathway, calcium modulating pathway|transcription factor binding|nuclear body|negative regulation of Wnt signaling pathway|calcineurin-NFAT signaling cascade|intracellular signal transduction|Fc-epsilon receptor signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|mitogen-activated protein kinase p38 binding|negative regulation of vascular associated smooth muscle cell differentiation|sequence-specific double-stranded DNA binding" "hsa04010,hsa04022,hsa04024,hsa04218,hsa04310,hsa04380,hsa04625,hsa04650,hsa04658,hsa04659,hsa04660,hsa04662,hsa04921,hsa04933,hsa05135,hsa05161,hsa05163,hsa05166,hsa05167,hsa05170,hsa05235,hsa05321" MAPK signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Cellular senescence|Wnt signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Oxytocin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Yersinia infection|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease RHD NFATC2 116.9974864 157.1024963 76.89247648 0.489441468 -1.030791754 0.020247261 0.810058917 0.875093569 0.421139942 4773 nuclear factor of activated T cells 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0001816,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0006974,GO:0008134,GO:0014904,GO:0016477,GO:0019902,GO:0030890,GO:0033173,GO:0038095,GO:0042493,GO:0045589,GO:0045893,GO:0045944,GO:0050853,GO:1901741,GO:1905064,GO:1990837,GO:1990904" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|cytokine production|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|transcription factor binding|myotube cell development|cell migration|phosphatase binding|positive regulation of B cell proliferation|calcineurin-NFAT signaling cascade|Fc-epsilon receptor signaling pathway|response to drug|regulation of regulatory T cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|B cell receptor signaling pathway|positive regulation of myoblast fusion|negative regulation of vascular associated smooth muscle cell differentiation|sequence-specific double-stranded DNA binding|ribonucleoprotein complex" "hsa04022,hsa04218,hsa04310,hsa04360,hsa04370,hsa04380,hsa04625,hsa04650,hsa04658,hsa04659,hsa04660,hsa04662,hsa04921,hsa05135,hsa05161,hsa05163,hsa05166,hsa05167,hsa05170,hsa05235" cGMP-PKG signaling pathway|Cellular senescence|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Oxytocin signaling pathway|Yersinia infection|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer NFATC2IP 2230.908715 2222.324053 2239.493377 1.007725842 0.011103198 0.96462147 1 30.59101116 30.31149848 84901 nuclear factor of activated T cells 2 interacting protein "GO:0001816,GO:0005634,GO:0005737,GO:0045944" cytokine production|nucleus|cytoplasm|positive regulation of transcription by RNA polymerase II NFATC3 710.5868608 764.7042037 656.4695179 0.858462023 -0.220173781 0.390236638 1 6.258374158 5.28267375 4775 nuclear factor of activated T cells 3 "GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0001816,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006357,GO:0006954,GO:0007275,GO:0008134,GO:0033173,GO:0038095,GO:0045944,GO:1902894,GO:1905064,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|cytokine production|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|inflammatory response|multicellular organism development|transcription factor binding|calcineurin-NFAT signaling cascade|Fc-epsilon receptor signaling pathway|positive regulation of transcription by RNA polymerase II|negative regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of vascular associated smooth muscle cell differentiation|sequence-specific double-stranded DNA binding" "hsa04010,hsa04022,hsa04218,hsa04310,hsa04360,hsa04625,hsa04658,hsa04659,hsa04660,hsa04662,hsa04921,hsa05135,hsa05161,hsa05163,hsa05166,hsa05167,hsa05170,hsa05235" MAPK signaling pathway|cGMP-PKG signaling pathway|Cellular senescence|Wnt signaling pathway|Axon guidance|C-type lectin receptor signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Oxytocin signaling pathway|Yersinia infection|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer RHD NFATC4 832.7624933 792.7953786 872.729608 1.100825801 0.13858619 0.582446487 1 7.766158638 8.406128727 4776 nuclear factor of activated T cells 4 "GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001569,GO:0001816,GO:0005515,GO:0005634,GO:0005667,GO:0005829,GO:0006357,GO:0006954,GO:0007507,GO:0007616,GO:0008134,GO:0008630,GO:0016607,GO:0030178,GO:0031547,GO:0032091,GO:0032760,GO:0033173,GO:0034644,GO:0035562,GO:0042975,GO:0043524,GO:0045333,GO:0045944,GO:0050774,GO:0051145,GO:0055001,GO:0060291,GO:0071285,GO:1902894,GO:1904637,GO:1990837,GO:2000297,GO:2001235" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|branching involved in blood vessel morphogenesis|cytokine production|protein binding|nucleus|transcription regulator complex|cytosol|regulation of transcription by RNA polymerase II|inflammatory response|heart development|long-term memory|transcription factor binding|intrinsic apoptotic signaling pathway in response to DNA damage|nuclear speck|negative regulation of Wnt signaling pathway|brain-derived neurotrophic factor receptor signaling pathway|negative regulation of protein binding|positive regulation of tumor necrosis factor production|calcineurin-NFAT signaling cascade|cellular response to UV|negative regulation of chromatin binding|peroxisome proliferator activated receptor binding|negative regulation of neuron apoptotic process|cellular respiration|positive regulation of transcription by RNA polymerase II|negative regulation of dendrite morphogenesis|smooth muscle cell differentiation|muscle cell development|long-term synaptic potentiation|cellular response to lithium ion|negative regulation of pri-miRNA transcription by RNA polymerase II|cellular response to ionomycin|sequence-specific double-stranded DNA binding|negative regulation of synapse maturation|positive regulation of apoptotic signaling pathway" "hsa04022,hsa04218,hsa04310,hsa04360,hsa04625,hsa04921,hsa05161,hsa05163,hsa05166,hsa05167,hsa05170" cGMP-PKG signaling pathway|Cellular senescence|Wnt signaling pathway|Axon guidance|C-type lectin receptor signaling pathway|Oxytocin signaling pathway|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection NFE2 8.085537281 10.40413883 5.766935736 0.554292463 -0.851280704 0.546153423 1 0.277486141 0.1512347 4778 "nuclear factor, erythroid 2" "GO:0000785,GO:0000978,GO:0000981,GO:0000987,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006337,GO:0006357,GO:0007275,GO:0007596,GO:0007599,GO:0016605,GO:0032993,GO:0043565,GO:0045652,GO:0045893,GO:0047485,GO:0050699,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|nucleosome disassembly|regulation of transcription by RNA polymerase II|multicellular organism development|blood coagulation|hemostasis|PML body|protein-DNA complex|sequence-specific DNA binding|regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-templated|protein N-terminus binding|WW domain binding|sequence-specific double-stranded DNA binding" TF_bZIP NFE2L1 6295.181406 7925.872958 4664.489854 0.588514335 -0.764850538 0.001719771 0.264245783 123.4644695 71.4447333 4779 "nuclear factor, erythroid 2 like 1" "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005789,GO:0005829,GO:0006357,GO:0006783,GO:0008203,GO:0008289,GO:0009653,GO:0016021,GO:0034599" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|endoplasmic reticulum membrane|cytosol|regulation of transcription by RNA polymerase II|heme biosynthetic process|cholesterol metabolic process|lipid binding|anatomical structure morphogenesis|integral component of membrane|cellular response to oxidative stress" NFE2L2 3191.993747 3292.909939 3091.077554 0.938706983 -0.091253203 0.700911197 1 55.26306645 51.00775469 4780 "nuclear factor, erythroid 2 like 2" "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001102,GO:0001221,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0005886,GO:0006357,GO:0006954,GO:0007568,GO:0010226,GO:0010499,GO:0010628,GO:0010667,GO:0010976,GO:0016032,GO:0016567,GO:0019904,GO:0030194,GO:0030968,GO:0032993,GO:0034599,GO:0035690,GO:0036003,GO:0036091,GO:0036499,GO:0042149,GO:0043161,GO:0043536,GO:0043565,GO:0045454,GO:0045766,GO:0045944,GO:0045995,GO:0046223,GO:0046326,GO:0061419,GO:0070301,GO:0071280,GO:0071356,GO:0071498,GO:0071499,GO:1902037,GO:1902176,GO:1903071,GO:1903206,GO:1903788,GO:1904385,GO:1904753,GO:2000121,GO:2000352,GO:2000379" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II activating transcription factor binding|transcription coregulator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|centrosome|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|inflammatory response|aging|response to lithium ion|proteasomal ubiquitin-independent protein catabolic process|positive regulation of gene expression|negative regulation of cardiac muscle cell apoptotic process|positive regulation of neuron projection development|viral process|protein ubiquitination|protein domain specific binding|positive regulation of blood coagulation|endoplasmic reticulum unfolded protein response|protein-DNA complex|cellular response to oxidative stress|cellular response to drug|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress|PERK-mediated unfolded protein response|cellular response to glucose starvation|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of blood vessel endothelial cell migration|sequence-specific DNA binding|cell redox homeostasis|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|regulation of embryonic development|aflatoxin catabolic process|positive regulation of glucose import|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to hydrogen peroxide|cellular response to copper ion|cellular response to tumor necrosis factor|cellular response to fluid shear stress|cellular response to laminar fluid shear stress|negative regulation of hematopoietic stem cell differentiation|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|negative regulation of hydrogen peroxide-induced cell death|positive regulation of glutathione biosynthetic process|cellular response to angiotensin|negative regulation of vascular associated smooth muscle cell migration|regulation of removal of superoxide radicals|negative regulation of endothelial cell apoptotic process|positive regulation of reactive oxygen species metabolic process" "hsa04141,hsa05012,hsa05200,hsa05225,hsa05418" Protein processing in endoplasmic reticulum|Parkinson disease|Pathways in cancer|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis TF_bZIP NFE2L3 2187.527135 2345.092891 2029.961379 0.865620883 -0.208192791 0.378760326 1 33.46344853 28.48194204 9603 "nuclear factor, erythroid 2 like 3" "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0006366" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II" NFIA 206.597612 225.7698125 187.4254114 0.830161523 -0.268536029 0.458822155 1 1.138516484 0.92933673 4774 nuclear factor I A "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003682,GO:0003700,GO:0005634,GO:0005654,GO:0006260,GO:0006355,GO:0006357,GO:0008134,GO:0019079,GO:0030054,GO:0045944,GO:0060074,GO:0072189" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|chromatin binding|DNA-binding transcription factor activity|nucleus|nucleoplasm|DNA replication|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription factor binding|viral genome replication|cell junction|positive regulation of transcription by RNA polymerase II|synapse maturation|ureter development" NFI NFIB 881.9192269 947.8170471 816.0214066 0.860948227 -0.21600161 0.386281439 1 4.864709924 4.11817847 4781 nuclear factor I B "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001650,GO:0002062,GO:0003677,GO:0005634,GO:0005654,GO:0006260,GO:0006357,GO:0007420,GO:0010001,GO:0021740,GO:0021960,GO:0044300,GO:0045893,GO:0045944,GO:0060486,GO:0060509,GO:0060510,GO:0061141,GO:0071679,GO:1902894,GO:1990837,GO:2000791,GO:2000795" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|fibrillar center|chondrocyte differentiation|DNA binding|nucleus|nucleoplasm|DNA replication|regulation of transcription by RNA polymerase II|brain development|glial cell differentiation|principal sensory nucleus of trigeminal nerve development|anterior commissure morphogenesis|cerebellar mossy fiber|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|club cell differentiation|type I pneumocyte differentiation|type II pneumocyte differentiation|lung ciliated cell differentiation|commissural neuron axon guidance|negative regulation of pri-miRNA transcription by RNA polymerase II|sequence-specific double-stranded DNA binding|negative regulation of mesenchymal cell proliferation involved in lung development|negative regulation of epithelial cell proliferation involved in lung morphogenesis" NFIC 1454.952574 1583.509929 1326.395219 0.837629872 -0.255615202 0.285002476 1 10.42806201 8.588690259 4782 nuclear factor I C "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001650,GO:0003700,GO:0005634,GO:0005654,GO:0006260,GO:0006357,GO:0006366,GO:0045944,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|fibrillar center|DNA-binding transcription factor activity|nucleus|nucleoplasm|DNA replication|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" NFI NFIL3 336.7292196 387.0339643 286.4244749 0.740049973 -0.434305401 0.15266103 1 7.093163234 5.161455413 4783 "nuclear factor, interleukin 3 regulated" "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0006366,GO:0006955,GO:0007623,GO:0045892,GO:0045893,GO:0071353" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription, DNA-templated|transcription by RNA polymerase II|immune response|circadian rhythm|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|cellular response to interleukin-4" TF_bZIP NFIX 987.9772762 1120.525752 855.4288008 0.763417351 -0.389456119 0.113420811 1 8.926765178 6.700810181 4784 nuclear factor I X "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0006260,GO:0006357,GO:0006366,GO:0045944,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|DNA replication|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" NFKB1 1759.303818 2117.242251 1401.365384 0.661882401 -0.595353185 0.012218804 0.656488938 25.34050855 16.49177262 4790 nuclear factor kappa B subunit 1 "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0002223,GO:0003682,GO:0003700,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006357,GO:0006366,GO:0006915,GO:0006954,GO:0008134,GO:0010629,GO:0010744,GO:0010884,GO:0010956,GO:0010957,GO:0031293,GO:0032269,GO:0032375,GO:0032481,GO:0032695,GO:0033256,GO:0034774,GO:0035580,GO:0035994,GO:0038095,GO:0042802,GO:0042805,GO:0043066,GO:0043312,GO:0045893,GO:0045944,GO:0050728,GO:0050852,GO:0051092,GO:0051403,GO:0070498,GO:0071222,GO:0071260,GO:0071316,GO:0071347,GO:0071354,GO:0071356,GO:0071359,GO:0090263,GO:1900127,GO:1904385,GO:2000630" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|stimulatory C-type lectin receptor signaling pathway|chromatin binding|DNA-binding transcription factor activity|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|apoptotic process|inflammatory response|transcription factor binding|negative regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of lipid storage|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of vitamin D biosynthetic process|membrane protein intracellular domain proteolysis|negative regulation of cellular protein metabolic process|negative regulation of cholesterol transport|positive regulation of type I interferon production|negative regulation of interleukin-12 production|I-kappaB/NF-kappaB complex|secretory granule lumen|specific granule lumen|response to muscle stretch|Fc-epsilon receptor signaling pathway|identical protein binding|actinin binding|negative regulation of apoptotic process|neutrophil degranulation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of inflammatory response|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|interleukin-1-mediated signaling pathway|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|cellular response to nicotine|cellular response to interleukin-1|cellular response to interleukin-6|cellular response to tumor necrosis factor|cellular response to dsRNA|positive regulation of canonical Wnt signaling pathway|positive regulation of hyaluronan biosynthetic process|cellular response to angiotensin|positive regulation of miRNA metabolic process" "hsa01523,hsa04010,hsa04014,hsa04024,hsa04062,hsa04064,hsa04066,hsa04071,hsa04151,hsa04210,hsa04211,hsa04218,hsa04380,hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04722,hsa04917,hsa04920,hsa04926,hsa04931,hsa04932,hsa04933,hsa05010,hsa05022,hsa05030,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05134,hsa05135,hsa05140,hsa05142,hsa05145,hsa05146,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05202,hsa05203,hsa05206,hsa05212,hsa05215,hsa05220,hsa05221,hsa05222,hsa05235,hsa05321,hsa05418" Antifolate resistance|MAPK signaling pathway|Ras signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|HIF-1 signaling pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Cellular senescence|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Prolactin signaling pathway|Adipocytokine signaling pathway|Relaxin signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Cocaine addiction|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|MicroRNAs in cancer|Pancreatic cancer|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease|Fluid shear stress and atherosclerosis RHD NFKB2 7231.37749 7850.963158 6611.791821 0.842163145 -0.247828354 0.311690709 1 102.3678168 84.76778819 4791 nuclear factor kappa B subunit 2 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0002268,GO:0002467,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0007568,GO:0030198,GO:0032481,GO:0032496,GO:0033257,GO:0034097,GO:0038061,GO:0045944,GO:0048511,GO:0048536,GO:0051092,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|follicular dendritic cell differentiation|germinal center formation|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|aging|extracellular matrix organization|positive regulation of type I interferon production|response to lipopolysaccharide|Bcl3/NF-kappaB2 complex|response to cytokine|NIK/NF-kappaB signaling|positive regulation of transcription by RNA polymerase II|rhythmic process|spleen development|positive regulation of NF-kappaB transcription factor activity|sequence-specific double-stranded DNA binding" "hsa04010,hsa04064,hsa04380,hsa04625,hsa05134,hsa05166,hsa05169,hsa05200,hsa05203,hsa05224" MAPK signaling pathway|NF-kappa B signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Legionellosis|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Breast cancer RHD NFKBIA 4423.247275 4454.011832 4392.482719 0.986185687 -0.02006878 0.93401653 1 152.4710874 147.8486528 4792 NFKB inhibitor alpha "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006606,GO:0006915,GO:0007249,GO:0007253,GO:0008134,GO:0008139,GO:0010745,GO:0010875,GO:0010888,GO:0016032,GO:0016579,GO:0019899,GO:0031625,GO:0031663,GO:0032088,GO:0032270,GO:0032495,GO:0033209,GO:0033256,GO:0034142,GO:0035994,GO:0042127,GO:0042802,GO:0042994,GO:0043066,GO:0043330,GO:0043392,GO:0045638,GO:0045746,GO:0045944,GO:0050729,GO:0051059,GO:0070417,GO:0070427,GO:0070431,GO:0070498,GO:1901222" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|protein import into nucleus|apoptotic process|I-kappaB kinase/NF-kappaB signaling|cytoplasmic sequestering of NF-kappaB|transcription factor binding|nuclear localization sequence binding|negative regulation of macrophage derived foam cell differentiation|positive regulation of cholesterol efflux|negative regulation of lipid storage|viral process|protein deubiquitination|enzyme binding|ubiquitin protein ligase binding|lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of cellular protein metabolic process|response to muramyl dipeptide|tumor necrosis factor-mediated signaling pathway|I-kappaB/NF-kappaB complex|toll-like receptor 4 signaling pathway|response to muscle stretch|regulation of cell population proliferation|identical protein binding|cytoplasmic sequestering of transcription factor|negative regulation of apoptotic process|response to exogenous dsRNA|negative regulation of DNA binding|negative regulation of myeloid cell differentiation|negative regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|positive regulation of inflammatory response|NF-kappaB binding|cellular response to cold|nucleotide-binding oligomerization domain containing 1 signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|interleukin-1-mediated signaling pathway|regulation of NIK/NF-kappaB signaling "hsa04024,hsa04062,hsa04064,hsa04210,hsa04380,hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04722,hsa04920,hsa04926,hsa04931,hsa05120,hsa05130,hsa05131,hsa05132,hsa05134,hsa05135,hsa05140,hsa05142,hsa05145,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05203,hsa05215,hsa05220,hsa05222,hsa05235" cAMP signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|Apoptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Adipocytokine signaling pathway|Relaxin signaling pathway|Insulin resistance|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Legionellosis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Prostate cancer|Chronic myeloid leukemia|Small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer NFKBIB 300.6217046 347.4982368 253.7451724 0.73020564 -0.453625283 0.14893607 1 12.70228919 9.120073906 4793 NFKB inhibitor beta "GO:0003713,GO:0005515,GO:0005634,GO:0005829,GO:0006351,GO:0007165,GO:0007253,GO:0045893,GO:0071222" "transcription coactivator activity|protein binding|nucleus|cytosol|transcription, DNA-templated|signal transduction|cytoplasmic sequestering of NF-kappaB|positive regulation of transcription, DNA-templated|cellular response to lipopolysaccharide" "hsa04062,hsa04621,hsa04622,hsa04623,hsa04658,hsa04659,hsa04660,hsa04662,hsa04722,hsa04920,hsa05130,hsa05131,hsa05140,hsa05145,hsa05162,hsa05164,hsa05169,hsa05171,hsa05235" Chemokine signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Neurotrophin signaling pathway|Adipocytokine signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Leishmaniasis|Toxoplasmosis|Measles|Influenza A|Epstein-Barr virus infection|Coronavirus disease - COVID-19|PD-L1 expression and PD-1 checkpoint pathway in cancer NFKBID 102.1542893 120.6880104 83.62056817 0.692865579 -0.529352609 0.255815502 1 1.815871807 1.237101549 84807 NFKB inhibitor delta "GO:0005515,GO:0005634,GO:0006954,GO:0010468,GO:0050852,GO:2000321" protein binding|nucleus|inflammatory response|regulation of gene expression|T cell receptor signaling pathway|positive regulation of T-helper 17 cell differentiation NFKBIE 324.0511386 344.3769952 303.7252821 0.881955782 -0.181221769 0.560174059 1 7.84077103 6.799496615 4794 NFKB inhibitor epsilon "GO:0001650,GO:0005515,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0042942,GO:0042994,GO:0048471" fibrillar center|protein binding|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|D-serine transport|cytoplasmic sequestering of transcription factor|perinuclear region of cytoplasm "hsa04658,hsa04659,hsa04660,hsa04662,hsa04722,hsa04920,hsa05169,hsa05235" Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Neurotrophin signaling pathway|Adipocytokine signaling pathway|Epstein-Barr virus infection|PD-L1 expression and PD-1 checkpoint pathway in cancer NFKBIL1 339.494415 282.9925761 395.9962539 1.399316757 0.484722576 0.109771804 1 9.877562895 13.59054952 4795 NFKB inhibitor like 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0007249,GO:0031665,GO:0032088,GO:0032720,GO:0034122,GO:0071222" protein binding|nucleus|nucleoplasm|cytosol|I-kappaB kinase/NF-kappaB signaling|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|negative regulation of tumor necrosis factor production|negative regulation of toll-like receptor signaling pathway|cellular response to lipopolysaccharide NFKBIZ 3374.795203 3537.407201 3212.183205 0.908061476 -0.139138123 0.557841864 1 45.0130951 40.19067554 64332 NFKB inhibitor zeta "GO:0005515,GO:0005634,GO:0006954,GO:0010468,GO:0016607,GO:0036464,GO:0050729,GO:0050852,GO:2000321" protein binding|nucleus|inflammatory response|regulation of gene expression|nuclear speck|cytoplasmic ribonucleoprotein granule|positive regulation of inflammatory response|T cell receptor signaling pathway|positive regulation of T-helper 17 cell differentiation hsa05202 Transcriptional misregulation in cancer NFRKB 607.6890677 700.198543 515.1795924 0.73576216 -0.442688614 0.091314067 1 5.683393054 4.111651709 4798 nuclear factor related to kappaB binding protein "GO:0002020,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006310,GO:0016579,GO:0031011" protease binding|DNA binding|protein binding|nucleus|nucleoplasm|DNA repair|DNA recombination|protein deubiquitination|Ino80 complex NFS1 739.5259495 704.3601985 774.6917005 1.099851613 0.137308895 0.591908036 1 12.49681158 13.51464047 9054 NFS1 cysteine desulfurase "GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0006777,GO:0016226,GO:0018283,GO:0030170,GO:0031071,GO:0032324,GO:0042803,GO:0044281,GO:0044571,GO:0046872,GO:0051536" protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|Mo-molybdopterin cofactor biosynthetic process|iron-sulfur cluster assembly|iron incorporation into metallo-sulfur cluster|pyridoxal phosphate binding|cysteine desulfurase activity|molybdopterin cofactor biosynthetic process|protein homodimerization activity|small molecule metabolic process|[2Fe-2S] cluster assembly|metal ion binding|iron-sulfur cluster binding "hsa00730,hsa04122" Thiamine metabolism|Sulfur relay system NFU1 618.5945206 570.1468077 667.0422335 1.169948204 0.22644466 0.387959733 1 13.86227209 15.94675172 27247 NFU1 iron-sulfur cluster scaffold "GO:0005506,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0016226,GO:0051539,GO:0097428" "iron ion binding|protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|iron-sulfur cluster assembly|4 iron, 4 sulfur cluster binding|protein maturation by iron-sulfur cluster transfer" NFX1 1234.026942 1334.851011 1133.202872 0.848935846 -0.236272562 0.328437121 1 12.5619018 10.48579697 4799 "nuclear transcription factor, X-box binding 1" "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0006355,GO:0006366,GO:0006954,GO:0008270,GO:0016032,GO:0016567,GO:0045347,GO:0051865,GO:0061630" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|plasma membrane|regulation of transcription, DNA-templated|transcription by RNA polymerase II|inflammatory response|zinc ion binding|viral process|protein ubiquitination|negative regulation of MHC class II biosynthetic process|protein autoubiquitination|ubiquitin protein ligase activity" hsa05165 Human papillomavirus infection NFXL1 473.8071854 503.5603192 444.0540517 0.881828918 -0.181429306 0.515282479 1 6.817374107 5.911159013 152518 "nuclear transcription factor, X-box binding like 1" "GO:0000785,GO:0000977,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0008270,GO:0016020,GO:0016021" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding|membrane|integral component of membrane" NFYA 683.2737884 665.8648849 700.6826919 1.052289598 0.0735318 0.779655039 1 5.72330248 5.921792084 4800 nuclear transcription factor Y subunit alpha "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0006366,GO:0016602,GO:0032993,GO:0045540,GO:0045893,GO:0048511,GO:0090575" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|CCAAT-binding factor complex|protein-DNA complex|regulation of cholesterol biosynthetic process|positive regulation of transcription, DNA-templated|rhythmic process|RNA polymerase II transcription regulator complex" "hsa04612,hsa05017,hsa05152" Antigen processing and presentation|Spinocerebellar ataxia|Tuberculosis NF-YA NFYB 685.4735031 673.1477821 697.7992241 1.036621144 0.051888726 0.845308473 1 8.537229072 8.701781543 4801 nuclear transcription factor Y subunit beta "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0016602,GO:0032993,GO:0045540,GO:0045944,GO:0046982,GO:0070491,GO:0090575" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|CCAAT-binding factor complex|protein-DNA complex|regulation of cholesterol biosynthetic process|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|repressing transcription factor binding|RNA polymerase II transcription regulator complex" "hsa04612,hsa05152,hsa05166" Antigen processing and presentation|Tuberculosis|Human T-cell leukemia virus 1 infection NF-YB/C NFYC 733.0645854 837.5331755 628.5959952 0.750532652 -0.414013257 0.103639774 1 8.74537395 6.45385426 4802 nuclear transcription factor Y subunit gamma "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0006457,GO:0008134,GO:0016602,GO:0032993,GO:0045540,GO:0045944,GO:0046982,GO:0090575" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|protein folding|transcription factor binding|CCAAT-binding factor complex|protein-DNA complex|regulation of cholesterol biosynthetic process|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|RNA polymerase II transcription regulator complex" "hsa04612,hsa05152" Antigen processing and presentation|Tuberculosis NF-YB/C NGDN 530.4065608 475.4691444 585.3439772 1.231087199 0.299932953 0.266792289 1 22.90154726 27.72201658 25983 neuroguidin "GO:0000462,GO:0000775,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0006417,GO:0030175,GO:0030424,GO:0030425,GO:0032040" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|chromosome, centromeric region|RNA binding|protein binding|nucleoplasm|nucleolus|mitochondrion|regulation of translation|filopodium|axon|dendrite|small-subunit processome" NGEF 15.65086762 19.76786377 11.53387147 0.583465751 -0.777280123 0.427928737 1 0.286833757 0.164557169 25791 neuronal guanine nucleotide exchange factor "GO:0005085,GO:0005515,GO:0005829,GO:0007186,GO:0007399,GO:0016020,GO:0030154,GO:0030426,GO:0043065,GO:0043087,GO:0048013,GO:0051056,GO:0061002,GO:0090630" guanyl-nucleotide exchange factor activity|protein binding|cytosol|G protein-coupled receptor signaling pathway|nervous system development|membrane|cell differentiation|growth cone|positive regulation of apoptotic process|regulation of GTPase activity|ephrin receptor signaling pathway|regulation of small GTPase mediated signal transduction|negative regulation of dendritic spine morphogenesis|activation of GTPase activity hsa04360 Axon guidance NGF 69.97065601 83.23311061 56.7082014 0.681317819 -0.553600155 0.300102103 1 1.074503662 0.719828149 4803 nerve growth factor "GO:0000186,GO:0005163,GO:0005515,GO:0005576,GO:0005615,GO:0005796,GO:0005829,GO:0006919,GO:0007169,GO:0007422,GO:0007613,GO:0008021,GO:0008083,GO:0008191,GO:0008285,GO:0008289,GO:0008625,GO:0010628,GO:0021675,GO:0030424,GO:0030425,GO:0031904,GO:0032455,GO:0033138,GO:0038180,GO:0043065,GO:0043066,GO:0043154,GO:0043281,GO:0043388,GO:0043524,GO:0045664,GO:0045666,GO:0046579,GO:0048011,GO:0048015,GO:0048672,GO:0048812,GO:0050772,GO:0050804" activation of MAPKK activity|nerve growth factor receptor binding|protein binding|extracellular region|extracellular space|Golgi lumen|cytosol|activation of cysteine-type endopeptidase activity involved in apoptotic process|transmembrane receptor protein tyrosine kinase signaling pathway|peripheral nervous system development|memory|synaptic vesicle|growth factor activity|metalloendopeptidase inhibitor activity|negative regulation of cell population proliferation|lipid binding|extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of gene expression|nerve development|axon|dendrite|endosome lumen|nerve growth factor processing|positive regulation of peptidyl-serine phosphorylation|nerve growth factor signaling pathway|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of DNA binding|negative regulation of neuron apoptotic process|regulation of neuron differentiation|positive regulation of neuron differentiation|positive regulation of Ras protein signal transduction|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of collateral sprouting|neuron projection morphogenesis|positive regulation of axonogenesis|modulation of chemical synaptic transmission "hsa04010,hsa04014,hsa04015,hsa04020,hsa04060,hsa04151,hsa04210,hsa04722,hsa04750" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Apoptosis|Neurotrophin signaling pathway|Inflammatory mediator regulation of TRP channels NGFR 14.53119581 15.60620824 13.45618338 0.86223272 -0.213850783 0.895568055 1 0.244388102 0.207193314 4804 nerve growth factor receptor "GO:0001540,GO:0001678,GO:0004888,GO:0005035,GO:0005515,GO:0005516,GO:0005576,GO:0005654,GO:0005768,GO:0005829,GO:0005886,GO:0005887,GO:0005911,GO:0006886,GO:0006919,GO:0007266,GO:0007411,GO:0007417,GO:0009986,GO:0014069,GO:0015026,GO:0016021,GO:0016048,GO:0021675,GO:0030426,GO:0031069,GO:0031267,GO:0031293,GO:0031625,GO:0032922,GO:0035907,GO:0038023,GO:0040037,GO:0042488,GO:0042593,GO:0043065,GO:0043066,GO:0043121,GO:0043154,GO:0043197,GO:0043204,GO:0043281,GO:0048011,GO:0048146,GO:0048406,GO:0050771,GO:0050772,GO:0051402,GO:0051799,GO:1900182,GO:1902895,GO:1903588,GO:1904646,GO:2001235" amyloid-beta binding|cellular glucose homeostasis|transmembrane signaling receptor activity|death receptor activity|protein binding|calmodulin binding|extracellular region|nucleoplasm|endosome|cytosol|plasma membrane|integral component of plasma membrane|cell-cell junction|intracellular protein transport|activation of cysteine-type endopeptidase activity involved in apoptotic process|Rho protein signal transduction|axon guidance|central nervous system development|cell surface|postsynaptic density|coreceptor activity|integral component of membrane|detection of temperature stimulus|nerve development|growth cone|hair follicle morphogenesis|small GTPase binding|membrane protein intracellular domain proteolysis|ubiquitin protein ligase binding|circadian regulation of gene expression|dorsal aorta development|signaling receptor activity|negative regulation of fibroblast growth factor receptor signaling pathway|positive regulation of odontogenesis of dentin-containing tooth|glucose homeostasis|positive regulation of apoptotic process|negative regulation of apoptotic process|neurotrophin binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|dendritic spine|perikaryon|regulation of cysteine-type endopeptidase activity involved in apoptotic process|neurotrophin TRK receptor signaling pathway|positive regulation of fibroblast proliferation|nerve growth factor binding|negative regulation of axonogenesis|positive regulation of axonogenesis|neuron apoptotic process|negative regulation of hair follicle development|positive regulation of protein localization to nucleus|positive regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|cellular response to amyloid-beta|positive regulation of apoptotic signaling pathway "hsa04010,hsa04014,hsa04015,hsa04060,hsa04151,hsa04215,hsa04722,hsa05202" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Apoptosis - multiple species|Neurotrophin signaling pathway|Transcriptional misregulation in cancer NGLY1 710.3050421 668.9861265 751.6239576 1.123526973 0.16803476 0.513271641 1 10.09687784 11.1542862 55768 N-glycanase 1 "GO:0000224,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006457,GO:0006515,GO:0006516,GO:0006517,GO:0046872" peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding|nucleus|cytoplasm|cytosol|protein folding|protein quality control for misfolded or incompletely synthesized proteins|glycoprotein catabolic process|protein deglycosylation|metal ion binding hsa04141 Protein processing in endoplasmic reticulum NGRN 1636.512285 1530.448821 1742.575748 1.138604391 0.187266569 0.431556091 1 60.95316474 68.24020022 51335 "neugrin, neurite outgrowth associated" "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0016604,GO:0019843,GO:0030182,GO:0031966,GO:0045171,GO:0070131,GO:0072686" RNA binding|protein binding|nucleus|nucleoplasm|mitochondrion|nuclear body|rRNA binding|neuron differentiation|mitochondrial membrane|intercellular bridge|positive regulation of mitochondrial translation|mitotic spindle NHEJ1 323.0553841 330.8516147 315.2591536 0.952871739 -0.069646061 0.830003774 1 2.184994753 2.04717997 79840 non-homologous end joining factor 1 "GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0006303,GO:0007417,GO:0010212,GO:0030183,GO:0030217,GO:0032807,GO:0045027,GO:0051351,GO:0070419" fibrillar center|protein binding|nucleus|nucleoplasm|double-strand break repair via nonhomologous end joining|central nervous system development|response to ionizing radiation|B cell differentiation|T cell differentiation|DNA ligase IV complex|DNA end binding|positive regulation of ligase activity|nonhomologous end joining complex hsa03450 Non-homologous end-joining NHLH1 3.844623824 0 7.689247648 Inf Inf 0.057816489 1 0 0.157799835 4807 nescient helix-loop-helix 1 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0007417,GO:0030154,GO:0045944,GO:0046983,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|central nervous system development|cell differentiation|positive regulation of transcription by RNA polymerase II|protein dimerization activity|sequence-specific double-stranded DNA binding" NHLRC1 4.562975582 6.242483296 2.883467868 0.461910386 -1.11431511 0.584550016 1 0.148860527 0.067609614 378884 NHL repeat containing E3 ubiquitin protein ligase 1 "GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005783,GO:0005829,GO:0005978,GO:0006914,GO:0010468,GO:0031398,GO:0034976,GO:0043161,GO:0045859,GO:0046872,GO:0048471,GO:0061630,GO:1903076" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|endoplasmic reticulum|cytosol|glycogen biosynthetic process|autophagy|regulation of gene expression|positive regulation of protein ubiquitination|response to endoplasmic reticulum stress|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of protein kinase activity|metal ion binding|perinuclear region of cytoplasm|ubiquitin protein ligase activity|regulation of protein localization to plasma membrane hsa04120 Ubiquitin mediated proteolysis NHLRC2 832.6234847 839.6140033 825.6329662 0.983348256 -0.024225652 0.927968345 1 4.038271108 3.904577096 374354 NHL repeat containing 2 "GO:0002576,GO:0005515,GO:0005576,GO:0005829,GO:0031093" platelet degranulation|protein binding|extracellular region|cytosol|platelet alpha granule lumen NHLRC3 443.1992642 431.7717613 454.6267672 1.052933072 0.074413737 0.798441193 1 6.755457443 6.994017393 387921 NHL repeat containing 3 "GO:0000209,GO:0005576,GO:0035578,GO:0043161,GO:0043312,GO:0061630" protein polyubiquitination|extracellular region|azurophil granule lumen|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|ubiquitin protein ligase activity NHP2 1203.756788 1120.525752 1286.987825 1.148557115 0.199822601 0.409889627 1 76.66717939 86.58312589 55651 NHP2 ribonucleoprotein "GO:0000469,GO:0000470,GO:0000781,GO:0003723,GO:0005515,GO:0005654,GO:0005697,GO:0005732,GO:0007004,GO:0031118,GO:0031120,GO:0031429,GO:0034513,GO:0070034,GO:0072589,GO:0090661,GO:1904874" "cleavage involved in rRNA processing|maturation of LSU-rRNA|chromosome, telomeric region|RNA binding|protein binding|nucleoplasm|telomerase holoenzyme complex|sno(s)RNA-containing ribonucleoprotein complex|telomere maintenance via telomerase|rRNA pseudouridine synthesis|snRNA pseudouridine synthesis|box H/ACA snoRNP complex|box H/ACA snoRNA binding|telomerase RNA binding|box H/ACA scaRNP complex|box H/ACA telomerase RNP complex|positive regulation of telomerase RNA localization to Cajal body" hsa03008 Ribosome biogenesis in eukaryotes NHS 403.0338893 424.4888641 381.5789145 0.898913839 -0.153745255 0.598860631 1 2.277489746 2.013008809 4810 NHS actin remodeling regulator "GO:0002088,GO:0005794,GO:0005923,GO:0005925,GO:0016324,GO:0016604,GO:0030027,GO:0030054,GO:0030154" lens development in camera-type eye|Golgi apparatus|bicellular tight junction|focal adhesion|apical plasma membrane|nuclear body|lamellipodium|cell junction|cell differentiation NHSL1 165.9321518 167.5066351 164.3576685 0.981200944 -0.027379473 0.961038028 1 0.558755 0.539076697 57224 NHS like 1 GO:0030154 cell differentiation NIBAN1 4696.060968 5434.081709 3958.040227 0.728373337 -0.457249984 0.056427552 1 40.26196771 28.83501716 116496 niban apoptosis regulator 1 "GO:0001933,GO:0001934,GO:0003674,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0034976,GO:0045727,GO:0070062" negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|molecular_function|protein binding|cytoplasm|cytosol|plasma membrane|membrane|response to endoplasmic reticulum stress|positive regulation of translation|extracellular exosome NIBAN2 10621.69377 9941.154649 11302.23289 1.136913496 0.185122489 0.463919259 1 126.2892532 141.1773402 64855 niban apoptosis regulator 2 "GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0007411,GO:0008285,GO:0016525,GO:0030154,GO:0030948,GO:0032274,GO:0040019,GO:0043066,GO:0044029,GO:0045296,GO:0045746,GO:0045892,GO:0045893,GO:0048743,GO:0070062,GO:2000279,GO:2000679" "transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|adherens junction|axon guidance|negative regulation of cell population proliferation|negative regulation of angiogenesis|cell differentiation|negative regulation of vascular endothelial growth factor receptor signaling pathway|gonadotropin secretion|positive regulation of embryonic development|negative regulation of apoptotic process|hypomethylation of CpG island|cadherin binding|negative regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of skeletal muscle fiber development|extracellular exosome|negative regulation of DNA biosynthetic process|positive regulation of transcription regulatory region DNA binding" NIBAN3 3.443303773 2.080827765 4.80577978 2.309551929 1.207612985 0.648665767 1 0.024476516 0.055583836 199786 niban apoptosis regulator 3 GO:0005515 protein binding NICN1 347.6239973 382.8723088 312.3756857 0.815874323 -0.293581158 0.330674806 1 6.331946524 5.079625354 84276 nicolin 1 "GO:0005515,GO:0005654,GO:0005874" protein binding|nucleoplasm|microtubule NID1 3583.767481 4330.20258 2837.332382 0.655242412 -0.609899354 0.010399547 0.610531935 39.89899052 25.70603453 4811 nidogen 1 "GO:0005201,GO:0005509,GO:0005518,GO:0005576,GO:0005604,GO:0005886,GO:0007160,GO:0010811,GO:0030198,GO:0032836,GO:0043236,GO:0043237,GO:0043394,GO:0062023,GO:0070062,GO:0071711" extracellular matrix structural constituent|calcium ion binding|collagen binding|extracellular region|basement membrane|plasma membrane|cell-matrix adhesion|positive regulation of cell-substrate adhesion|extracellular matrix organization|glomerular basement membrane development|laminin binding|laminin-1 binding|proteoglycan binding|collagen-containing extracellular matrix|extracellular exosome|basement membrane organization NIF3L1 786.0376034 764.7042037 807.371003 1.055795168 0.078329968 0.760111028 1 21.23353688 22.04312632 60491 NGG1 interacting factor 3 like 1 "GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0008134,GO:0030182,GO:0042802,GO:0045893,GO:1903507" "protein binding|nucleus|cytoplasm|mitochondrion|transcription factor binding|neuron differentiation|identical protein binding|positive regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription" NIFK 936.2440457 998.7973273 873.690764 0.874742793 -0.193069221 0.436176589 1 31.61564511 27.1927794 84365 nucleolar protein interacting with the FHA domain of MKI67 "GO:0000463,GO:0000794,GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0009303,GO:0016072,GO:0065003" "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|condensed nuclear chromosome|RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|cytoplasm|rRNA transcription|rRNA metabolic process|protein-containing complex assembly" NIM1K 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.072016831 0.021805781 167359 NIM1 serine/threonine protein kinase "GO:0000287,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0035556,GO:0042149,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|intracellular signal transduction|cellular response to glucose starvation|protein serine kinase activity|protein threonine kinase activity NIN 2397.919681 2594.792223 2201.047139 0.84825564 -0.237428977 0.315236546 1 10.75901577 8.973677935 51199 ninein "GO:0000242,GO:0000922,GO:0005509,GO:0005515,GO:0005525,GO:0005654,GO:0005730,GO:0005813,GO:0005814,GO:0005881,GO:0005886,GO:0008104,GO:0010457,GO:0019900,GO:0021540,GO:0021957,GO:0030425,GO:0031116,GO:0034454,GO:0044295,GO:0045177,GO:0048668,GO:0050772,GO:0051011,GO:0051642,GO:0072686,GO:0090222,GO:0097431,GO:0097539,GO:0120103" pericentriolar material|spindle pole|calcium ion binding|protein binding|GTP binding|nucleoplasm|nucleolus|centrosome|centriole|cytoplasmic microtubule|plasma membrane|protein localization|centriole-centriole cohesion|kinase binding|corpus callosum morphogenesis|corticospinal tract morphogenesis|dendrite|positive regulation of microtubule polymerization|microtubule anchoring at centrosome|axonal growth cone|apical part of cell|collateral sprouting|positive regulation of axonogenesis|microtubule minus-end binding|centrosome localization|mitotic spindle|centrosome-templated microtubule nucleation|mitotic spindle pole|ciliary transition fiber|centriolar subdistal appendage NINJ1 813.043705 830.2502783 795.8371316 0.958550876 -0.061073089 0.812121044 1 34.24183263 32.27329793 4814 ninjurin 1 "GO:0005515,GO:0007155,GO:0007399,GO:0016021,GO:0042246" protein binding|cell adhesion|nervous system development|integral component of membrane|tissue regeneration NINL 521.5227994 557.6618411 485.3837578 0.870390839 -0.200264723 0.461680633 1 3.239863653 2.772759639 22981 ninein like "GO:0000086,GO:0005509,GO:0005515,GO:0005813,GO:0005829,GO:0005874,GO:0010389,GO:0015630,GO:0034454,GO:0045171,GO:0097711" G2/M transition of mitotic cell cycle|calcium ion binding|protein binding|centrosome|cytosol|microtubule|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|microtubule anchoring at centrosome|intercellular bridge|ciliary basal body-plasma membrane docking NIP7 803.3132585 827.1290367 779.4974803 0.942413391 -0.085568056 0.737388336 1 21.48046545 19.90473109 51388 nucleolar pre-rRNA processing protein NIP7 "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0030687,GO:0042255,GO:0042273" "RNA binding|protein binding|nucleoplasm|nucleolus|cytosol|preribosome, large subunit precursor|ribosome assembly|ribosomal large subunit biogenesis" NIPA1 1419.553965 1474.266472 1364.841458 0.925776638 -0.111263938 0.643646565 1 11.96273255 10.88949624 123606 NIPA magnesium transporter 1 "GO:0005515,GO:0005769,GO:0005886,GO:0015095,GO:0015693,GO:0016020,GO:0016021,GO:0055085,GO:1903830" protein binding|early endosome|plasma membrane|magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane|transmembrane transport|magnesium ion transmembrane transport NIPA2 1498.229744 1521.085096 1475.374392 0.969948621 -0.044019766 0.856238648 1 20.17835346 19.24445577 81614 NIPA magnesium transporter 2 "GO:0005769,GO:0005886,GO:0015095,GO:0015693,GO:0016020,GO:0016021,GO:1903830" early endosome|plasma membrane|magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane|magnesium ion transmembrane transport NIPAL1 482.3481486 576.389291 388.3070062 0.673688794 -0.569845793 0.038589051 0.988212125 5.801742192 3.843164095 152519 NIPA like domain containing 1 "GO:0015095,GO:0015693,GO:0016020,GO:0016021,GO:1903830" magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane|magnesium ion transmembrane transport NIPAL2 134.5461282 138.3750464 130.71721 0.944658834 -0.082134704 0.862452379 1 1.534986885 1.425774484 79815 NIPA like domain containing 2 "GO:0015095,GO:0015693,GO:0016020,GO:0016021,GO:1903830" magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane|magnesium ion transmembrane transport NIPAL3 781.8224564 590.9550853 972.6898275 1.645962361 0.718931345 0.00449147 0.412329403 4.169511737 6.748018724 57185 NIPA like domain containing 3 "GO:0005515,GO:0015095,GO:0015693,GO:0016020,GO:0016021,GO:1903830" protein binding|magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane|magnesium ion transmembrane transport NIPAL4 74.77140537 95.7180772 53.82473354 0.562325687 -0.830522144 0.109077558 1 1.459096789 0.806757856 348938 NIPA like domain containing 4 "GO:0005515,GO:0015095,GO:0015693,GO:0016020,GO:0016021,GO:1903830" protein binding|magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane|magnesium ion transmembrane transport NIPBL 1842.147512 1958.058927 1726.236097 0.881605795 -0.181794388 0.443472744 1 8.793167804 7.622386668 25836 NIPBL cohesin loading factor "GO:0000122,GO:0001656,GO:0003007,GO:0003151,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006974,GO:0007064,GO:0007420,GO:0007605,GO:0008022,GO:0019827,GO:0031065,GO:0032039,GO:0032116,GO:0034087,GO:0034088,GO:0034613,GO:0035115,GO:0035136,GO:0035261,GO:0036033,GO:0040018,GO:0042471,GO:0042634,GO:0042826,GO:0043231,GO:0045444,GO:0045778,GO:0045892,GO:0045995,GO:0047485,GO:0048557,GO:0048565,GO:0048589,GO:0048592,GO:0048638,GO:0048703,GO:0050890,GO:0060325,GO:0061010,GO:0061038,GO:0070062,GO:0070087,GO:0071169,GO:0071481,GO:0071733,GO:0071921,GO:0090694,GO:1905406,GO:1990414,GO:1990841,GO:2001224" "negative regulation of transcription by RNA polymerase II|metanephros development|heart morphogenesis|outflow tract morphogenesis|chromatin binding|protein binding|nucleus|nucleoplasm|cytosol|cellular response to DNA damage stimulus|mitotic sister chromatid cohesion|brain development|sensory perception of sound|protein C-terminus binding|stem cell population maintenance|positive regulation of histone deacetylation|integrator complex|SMC loading complex|establishment of mitotic sister chromatid cohesion|maintenance of mitotic sister chromatid cohesion|cellular protein localization|embryonic forelimb morphogenesis|forelimb morphogenesis|external genitalia morphogenesis|mediator complex binding|positive regulation of multicellular organism growth|ear morphogenesis|regulation of hair cycle|histone deacetylase binding|intracellular membrane-bounded organelle|fat cell differentiation|positive regulation of ossification|negative regulation of transcription, DNA-templated|regulation of embryonic development|protein N-terminus binding|embryonic digestive tract morphogenesis|digestive tract development|developmental growth|eye morphogenesis|regulation of developmental growth|embryonic viscerocranium morphogenesis|cognition|face morphogenesis|gall bladder development|uterus morphogenesis|extracellular exosome|chromo shadow domain binding|establishment of protein localization to chromatin|cellular response to X-ray|transcriptional activation by promoter-enhancer looping|cohesin loading|Scc2-Scc4 cohesin loading complex|positive regulation of mitotic cohesin loading|replication-born double-strand break repair via sister chromatid exchange|promoter-specific chromatin binding|positive regulation of neuron migration" other NIPSNAP1 3486.681782 3358.456013 3614.90755 1.076359951 0.106160618 0.655259181 1 89.03856177 94.23383053 8508 nipsnap homolog 1 "GO:0005515,GO:0005739,GO:0019233,GO:0042165,GO:0097060" protein binding|mitochondrion|sensory perception of pain|neurotransmitter binding|synaptic membrane NIPSNAP2 1662.908861 1617.843588 1707.974134 1.055710297 0.078213991 0.743913714 1 43.32229744 44.97046888 2631 nipsnap homolog 2 "GO:0005515,GO:0005739,GO:0005741,GO:0006119,GO:0007005,GO:1901843" protein binding|mitochondrion|mitochondrial outer membrane|oxidative phosphorylation|mitochondrion organization|positive regulation of high voltage-gated calcium channel activity NIPSNAP3A 389.5732899 336.0536841 443.0928957 1.318518191 0.398917476 0.171142307 1 10.96244956 14.21231788 25934 nipsnap homolog 3A "GO:0005515,GO:0005634,GO:0005739,GO:0005829" protein binding|nucleus|mitochondrion|cytosol NIPSNAP3B 181.4194731 195.5978099 167.2411363 0.855025608 -0.225960466 0.55611741 1 1.758836668 1.478685491 55335 nipsnap homolog 3B GO:0005739 mitochondrion NISCH 1750.769728 1729.167873 1772.371583 1.024985261 0.035603164 0.883049689 1 12.93377874 13.03509576 11188 nischarin "GO:0005178,GO:0005515,GO:0005654,GO:0005737,GO:0005769,GO:0005829,GO:0005886,GO:0006006,GO:0006915,GO:0008217,GO:0015630,GO:0016020,GO:0016601,GO:0019901,GO:0030036,GO:0030336,GO:0032228,GO:0035091,GO:0042802,GO:0043231,GO:0045171,GO:0048243,GO:0055037" "integrin binding|protein binding|nucleoplasm|cytoplasm|early endosome|cytosol|plasma membrane|glucose metabolic process|apoptotic process|regulation of blood pressure|microtubule cytoskeleton|membrane|Rac protein signal transduction|protein kinase binding|actin cytoskeleton organization|negative regulation of cell migration|regulation of synaptic transmission, GABAergic|phosphatidylinositol binding|identical protein binding|intracellular membrane-bounded organelle|intercellular bridge|norepinephrine secretion|recycling endosome" NIT1 1257.031132 1194.395137 1319.667128 1.104883205 0.143893874 0.552317256 1 20.06379392 21.79719498 4817 nitrilase 1 "GO:0005634,GO:0005737,GO:0005739,GO:0043605,GO:0110050" nucleus|cytoplasm|mitochondrion|cellular amide catabolic process|deaminated glutathione amidase activity NIT2 651.9569619 663.7840571 640.1298667 0.96436463 -0.052349357 0.845372638 1 4.897682171 4.644115912 56954 nitrilase family member 2 "GO:0005576,GO:0005813,GO:0005829,GO:0006107,GO:0006528,GO:0006541,GO:0035580,GO:0043312,GO:0050152,GO:0070062,GO:1904724" extracellular region|centrosome|cytosol|oxaloacetate metabolic process|asparagine metabolic process|glutamine metabolic process|specific granule lumen|neutrophil degranulation|omega-amidase activity|extracellular exosome|tertiary granule lumen hsa00250 "Alanine, aspartate and glutamate metabolism" NKAP 765.6753052 709.562268 821.7883424 1.158162404 0.211837571 0.403760054 1 6.277857116 7.149111467 79576 NFKB activating protein "GO:0000122,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0007219,GO:0010468,GO:0045892,GO:0046638" "negative regulation of transcription by RNA polymerase II|chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|Notch signaling pathway|regulation of gene expression|negative regulation of transcription, DNA-templated|positive regulation of alpha-beta T cell differentiation" NKAPD1 694.544734 722.0472346 667.0422335 0.923820772 -0.11431511 0.659357225 1 12.31916044 11.19025576 55216 NKAP domain containing 1 "GO:0005515,GO:0042802" protein binding|identical protein binding NKD1 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.003188159 0.008688006 85407 NKD inhibitor of WNT signaling pathway 1 "GO:0000159,GO:0001754,GO:0005509,GO:0005515,GO:0005737,GO:0005886,GO:0007525,GO:0016055,GO:0030165,GO:0030178,GO:0045732,GO:0090090,GO:0090249,GO:1901231,GO:1901233,GO:2000096" "protein phosphatase type 2A complex|eye photoreceptor cell differentiation|calcium ion binding|protein binding|cytoplasm|plasma membrane|somatic muscle development|Wnt signaling pathway|PDZ domain binding|negative regulation of Wnt signaling pathway|positive regulation of protein catabolic process|negative regulation of canonical Wnt signaling pathway|regulation of cell migration involved in somitogenic axis elongation|positive regulation of non-canonical Wnt signaling pathway via JNK cascade|negative regulation of convergent extension involved in axis elongation|positive regulation of Wnt signaling pathway, planar cell polarity pathway" "hsa04310,hsa04390" Wnt signaling pathway|Hippo signaling pathway NKIRAS1 404.4611464 361.0236173 447.8986755 1.240635388 0.311079182 0.281674652 1 3.291282357 4.014953181 28512 NFKB inhibitor interacting Ras like 1 "GO:0003924,GO:0005525,GO:0005575,GO:0005783,GO:0005829,GO:0007249" GTPase activity|GTP binding|cellular_component|endoplasmic reticulum|cytosol|I-kappaB kinase/NF-kappaB signaling NKIRAS2 788.1379384 819.8461395 756.4297374 0.92264841 -0.116147104 0.648016873 1 16.90636849 15.337612 28511 NFKB inhibitor interacting Ras like 2 "GO:0003924,GO:0005525,GO:0005575,GO:0005737,GO:0007249" GTPase activity|GTP binding|cellular_component|cytoplasm|I-kappaB kinase/NF-kappaB signaling NKRF 989.9498923 995.6760857 984.2236989 0.988497879 -0.016690224 0.950352547 1 13.99826204 13.60570466 55922 NFKB repressing factor "GO:0000978,GO:0001228,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0045892,GO:0045944" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II" NKTR 3017.634488 3068.18054 2967.088436 0.967051449 -0.048335449 0.839419025 1 14.47261414 13.76156234 4820 natural killer cell triggering receptor "GO:0000413,GO:0003755,GO:0005634,GO:0005737,GO:0005886,GO:0006457,GO:0016018,GO:0043231" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|nucleus|cytoplasm|plasma membrane|protein folding|cyclosporin A binding|intracellular membrane-bounded organelle NKX2-5 132.1878977 126.9304937 137.4453017 1.082839101 0.114818889 0.80235798 1 2.60841246 2.777226973 1482 NK2 homeobox 5 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001216,GO:0001228,GO:0001570,GO:0001947,GO:0003007,GO:0003148,GO:0003161,GO:0003180,GO:0003221,GO:0003228,GO:0003285,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005667,GO:0006357,GO:0007512,GO:0008134,GO:0008284,GO:0010667,GO:0010735,GO:0010765,GO:0010832,GO:0030097,GO:0030154,GO:0030878,GO:0032991,GO:0032993,GO:0035050,GO:0043066,GO:0043565,GO:0045666,GO:0045823,GO:0045892,GO:0045893,GO:0045944,GO:0048536,GO:0051891,GO:0055007,GO:0055008,GO:0055013,GO:0055014,GO:0055015,GO:0055117,GO:0060037,GO:0060048,GO:0060261,GO:0060412,GO:0060413,GO:0090090,GO:0090575,GO:1903779,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity|DNA-binding transcription activator activity, RNA polymerase II-specific|vasculogenesis|heart looping|heart morphogenesis|outflow tract septum morphogenesis|cardiac conduction system development|aortic valve morphogenesis|right ventricular cardiac muscle tissue morphogenesis|atrial cardiac muscle tissue development|septum secundum development|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|adult heart development|transcription factor binding|positive regulation of cell population proliferation|negative regulation of cardiac muscle cell apoptotic process|positive regulation of transcription via serum response element binding|positive regulation of sodium ion transport|negative regulation of myotube differentiation|hemopoiesis|cell differentiation|thyroid gland development|protein-containing complex|protein-DNA complex|embryonic heart tube development|negative regulation of apoptotic process|sequence-specific DNA binding|positive regulation of neuron differentiation|positive regulation of heart contraction|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|spleen development|positive regulation of cardioblast differentiation|cardiac muscle cell differentiation|cardiac muscle tissue morphogenesis|cardiac muscle cell development|atrial cardiac muscle cell development|ventricular cardiac muscle cell development|regulation of cardiac muscle contraction|pharyngeal system development|cardiac muscle contraction|positive regulation of transcription initiation from RNA polymerase II promoter|ventricular septum morphogenesis|atrial septum morphogenesis|negative regulation of canonical Wnt signaling pathway|RNA polymerase II transcription regulator complex|regulation of cardiac conduction|sequence-specific double-stranded DNA binding" Homeobox NKX2-8 3.562190663 5.202069413 1.922311912 0.369528309 -1.436243205 0.543489417 1 0.150637484 0.05473334 26257 NK2 homeobox 8 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001889,GO:0003690,GO:0003700,GO:0005575,GO:0005634,GO:0006351,GO:0006357,GO:0006366,GO:0007409,GO:0030154,GO:0030324,GO:0043565,GO:0045944,GO:0050680,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|liver development|double-stranded DNA binding|DNA-binding transcription factor activity|cellular_component|nucleus|transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|axonogenesis|cell differentiation|lung development|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|negative regulation of epithelial cell proliferation|sequence-specific double-stranded DNA binding" NKX3-1 213.7716831 212.2444321 215.2989341 1.014391436 0.02061447 0.968330017 1 3.45127826 3.442363501 4824 NK3 homeobox 1 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001656,GO:0001756,GO:0001934,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006357,GO:0006919,GO:0007275,GO:0007431,GO:0007507,GO:0008134,GO:0008284,GO:0008285,GO:0008584,GO:0008656,GO:0010628,GO:0010629,GO:0010942,GO:0014068,GO:0030154,GO:0030284,GO:0030331,GO:0030521,GO:0032880,GO:0033574,GO:0035690,GO:0035907,GO:0042826,GO:0043280,GO:0043491,GO:0043565,GO:0043569,GO:0043621,GO:0045892,GO:0045893,GO:0045930,GO:0045931,GO:0045944,GO:0048754,GO:0050680,GO:0051091,GO:0051781,GO:0060037,GO:0060442,GO:0060664,GO:0060770,GO:0071347,GO:0071356,GO:0071383,GO:0071456,GO:0071850,GO:0071899,GO:0090734,GO:0097162,GO:1990837,GO:2000836,GO:2001022,GO:2001235,GO:2001244" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|metanephros development|somitogenesis|positive regulation of protein phosphorylation|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|activation of cysteine-type endopeptidase activity involved in apoptotic process|multicellular organism development|salivary gland development|heart development|transcription factor binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|male gonad development|cysteine-type endopeptidase activator activity involved in apoptotic process|positive regulation of gene expression|negative regulation of gene expression|positive regulation of cell death|positive regulation of phosphatidylinositol 3-kinase signaling|cell differentiation|estrogen receptor activity|estrogen receptor binding|androgen receptor signaling pathway|regulation of protein localization|response to testosterone|cellular response to drug|dorsal aorta development|histone deacetylase binding|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein kinase B signaling|sequence-specific DNA binding|negative regulation of insulin-like growth factor receptor signaling pathway|protein self-association|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|branching morphogenesis of an epithelial tube|negative regulation of epithelial cell proliferation|positive regulation of DNA-binding transcription factor activity|positive regulation of cell division|pharyngeal system development|branching involved in prostate gland morphogenesis|epithelial cell proliferation involved in salivary gland morphogenesis|negative regulation of epithelial cell proliferation involved in prostate gland development|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to steroid hormone stimulus|cellular response to hypoxia|mitotic cell cycle arrest|negative regulation of estrogen receptor binding|site of DNA damage|MADS box domain binding|sequence-specific double-stranded DNA binding|positive regulation of androgen secretion|positive regulation of response to DNA damage stimulus|positive regulation of apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway" "hsa05200,hsa05215" Pathways in cancer|Prostate cancer Homeobox NKX3-2 11.40995416 9.363724944 13.45618338 1.437054534 0.523114811 0.682534404 1 0.221215047 0.312578492 579 NK3 homeobox 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001501,GO:0005515,GO:0005634,GO:0006357,GO:0006366,GO:0007368,GO:0030154,GO:0031016,GO:0032331,GO:0042474,GO:0043066,GO:0048536,GO:0048645,GO:0048705,GO:0048706,GO:0060576,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|skeletal system development|protein binding|nucleus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|determination of left/right symmetry|cell differentiation|pancreas development|negative regulation of chondrocyte differentiation|middle ear morphogenesis|negative regulation of apoptotic process|spleen development|animal organ formation|skeletal system morphogenesis|embryonic skeletal system development|intestinal epithelial cell development|sequence-specific double-stranded DNA binding" NLE1 754.3635018 854.1797976 654.547206 0.766287388 -0.384042534 0.129669019 1 8.517564627 6.417683479 54475 notchless homolog 1 "GO:0000027,GO:0001756,GO:0001822,GO:0001826,GO:0005654,GO:0005730,GO:0007219,GO:0045930,GO:0048705,GO:0061484,GO:0090263,GO:2001268" ribosomal large subunit assembly|somitogenesis|kidney development|inner cell mass cell differentiation|nucleoplasm|nucleolus|Notch signaling pathway|negative regulation of mitotic cell cycle|skeletal system morphogenesis|hematopoietic stem cell homeostasis|positive regulation of canonical Wnt signaling pathway|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway NLGN1 2.080827765 4.161655531 0 0 #NAME? 0.234194363 1 0.008768601 0 22871 neuroligin 1 "GO:0001540,GO:0002087,GO:0005794,GO:0005886,GO:0005887,GO:0006605,GO:0007157,GO:0007158,GO:0007268,GO:0007399,GO:0007416,GO:0009897,GO:0009986,GO:0010841,GO:0014069,GO:0016080,GO:0016339,GO:0017146,GO:0023041,GO:0030165,GO:0030425,GO:0031175,GO:0032230,GO:0032433,GO:0035418,GO:0038023,GO:0042043,GO:0042802,GO:0043083,GO:0043197,GO:0043198,GO:0043235,GO:0044877,GO:0045184,GO:0045202,GO:0045664,GO:0048488,GO:0048489,GO:0048511,GO:0048789,GO:0050804,GO:0050839,GO:0051491,GO:0051965,GO:0051968,GO:0060076,GO:0060291,GO:0060999,GO:0061002,GO:0071277,GO:0072553,GO:0089717,GO:0097091,GO:0097104,GO:0097105,GO:0097110,GO:0097113,GO:0097114,GO:0097115,GO:0097119,GO:0097120,GO:0098698,GO:0098793,GO:0098794,GO:0098942,GO:0098985,GO:0099054,GO:0099055,GO:0099060,GO:0099560,GO:0140058,GO:1900029,GO:1900244,GO:1902474,GO:1902533,GO:1904861,GO:1905520,GO:2000302,GO:2000310,GO:2000311,GO:2000463,GO:2000809" "amyloid-beta binding|regulation of respiratory gaseous exchange by nervous system process|Golgi apparatus|plasma membrane|integral component of plasma membrane|protein targeting|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|neuron cell-cell adhesion|chemical synaptic transmission|nervous system development|synapse assembly|external side of plasma membrane|cell surface|positive regulation of circadian sleep/wake cycle, wakefulness|postsynaptic density|synaptic vesicle targeting|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|NMDA selective glutamate receptor complex|neuronal signal transduction|PDZ domain binding|dendrite|neuron projection development|positive regulation of synaptic transmission, GABAergic|filopodium tip|protein localization to synapse|signaling receptor activity|neurexin family protein binding|identical protein binding|synaptic cleft|dendritic spine|dendritic shaft|receptor complex|protein-containing complex binding|establishment of protein localization|synapse|regulation of neuron differentiation|synaptic vesicle endocytosis|synaptic vesicle transport|rhythmic process|cytoskeletal matrix organization at active zone|modulation of chemical synaptic transmission|cell adhesion molecule binding|positive regulation of filopodium assembly|positive regulation of synapse assembly|positive regulation of synaptic transmission, glutamatergic|excitatory synapse|long-term synaptic potentiation|positive regulation of dendritic spine development|negative regulation of dendritic spine morphogenesis|cellular response to calcium ion|terminal button organization|spanning component of membrane|synaptic vesicle clustering|postsynaptic membrane assembly|presynaptic membrane assembly|scaffold protein binding|AMPA glutamate receptor clustering|NMDA glutamate receptor clustering|neurexin clustering involved in presynaptic membrane assembly|postsynaptic density protein 95 clustering|receptor localization to synapse|postsynaptic specialization assembly|presynapse|postsynapse|retrograde trans-synaptic signaling by trans-synaptic protein complex|asymmetric, glutamatergic, excitatory synapse|presynapse assembly|integral component of postsynaptic membrane|integral component of postsynaptic specialization membrane|synaptic membrane adhesion|neuron projection arborization|positive regulation of ruffle assembly|positive regulation of synaptic vesicle endocytosis|positive regulation of protein localization to synapse|positive regulation of intracellular signal transduction|excitatory synapse assembly|positive regulation of presynaptic active zone assembly|positive regulation of synaptic vesicle exocytosis|regulation of NMDA receptor activity|regulation of AMPA receptor activity|positive regulation of excitatory postsynaptic potential|positive regulation of synaptic vesicle clustering" hsa04514 Cell adhesion molecules NLGN2 1733.915515 1614.722346 1853.108683 1.147633021 0.198661384 0.403034457 1 16.90032631 19.07081724 57555 neuroligin 2 "GO:0002087,GO:0005886,GO:0005887,GO:0007158,GO:0007268,GO:0007416,GO:0009986,GO:0016020,GO:0019233,GO:0032024,GO:0032230,GO:0035418,GO:0035641,GO:0038023,GO:0042043,GO:0042734,GO:0042802,GO:0042995,GO:0045202,GO:0045211,GO:0045217,GO:0048488,GO:0050804,GO:0050808,GO:0050839,GO:0050885,GO:0051965,GO:0051968,GO:0060077,GO:0072553,GO:0089717,GO:0097104,GO:0097105,GO:0097116,GO:0097119,GO:0097151,GO:0098609,GO:0098690,GO:0098691,GO:0098983,GO:0099054,GO:0099055,GO:0099060,GO:1902474,GO:1904862,GO:2000311,GO:2000463,GO:2000809" "regulation of respiratory gaseous exchange by nervous system process|plasma membrane|integral component of plasma membrane|neuron cell-cell adhesion|chemical synaptic transmission|synapse assembly|cell surface|membrane|sensory perception of pain|positive regulation of insulin secretion|positive regulation of synaptic transmission, GABAergic|protein localization to synapse|locomotory exploration behavior|signaling receptor activity|neurexin family protein binding|presynaptic membrane|identical protein binding|cell projection|synapse|postsynaptic membrane|cell-cell junction maintenance|synaptic vesicle endocytosis|modulation of chemical synaptic transmission|synapse organization|cell adhesion molecule binding|neuromuscular process controlling balance|positive regulation of synapse assembly|positive regulation of synaptic transmission, glutamatergic|inhibitory synapse|terminal button organization|spanning component of membrane|postsynaptic membrane assembly|presynaptic membrane assembly|gephyrin clustering involved in postsynaptic density assembly|postsynaptic density protein 95 clustering|positive regulation of inhibitory postsynaptic potential|cell-cell adhesion|glycinergic synapse|dopaminergic synapse|symmetric, GABA-ergic, inhibitory synapse|presynapse assembly|integral component of postsynaptic membrane|integral component of postsynaptic specialization membrane|positive regulation of protein localization to synapse|inhibitory synapse assembly|regulation of AMPA receptor activity|positive regulation of excitatory postsynaptic potential|positive regulation of synaptic vesicle clustering" hsa04514 Cell adhesion molecules NLGN3 7.525701377 8.323311061 6.728091692 0.808343175 -0.306960188 0.918003413 1 0.060271345 0.047904668 54413 neuroligin 3 "GO:0002087,GO:0005515,GO:0005886,GO:0005887,GO:0006898,GO:0007158,GO:0007268,GO:0007416,GO:0007612,GO:0009986,GO:0030139,GO:0030534,GO:0035176,GO:0038023,GO:0042043,GO:0045202,GO:0048488,GO:0048675,GO:0050804,GO:0050808,GO:0050839,GO:0051965,GO:0051968,GO:0060024,GO:0060076,GO:0060080,GO:0071625,GO:0089717,GO:0097104,GO:0097105,GO:0097110,GO:0098793,GO:0098983,GO:0098985,GO:0099054,GO:0099055,GO:2000463,GO:2000969" "regulation of respiratory gaseous exchange by nervous system process|protein binding|plasma membrane|integral component of plasma membrane|receptor-mediated endocytosis|neuron cell-cell adhesion|chemical synaptic transmission|synapse assembly|learning|cell surface|endocytic vesicle|adult behavior|social behavior|signaling receptor activity|neurexin family protein binding|synapse|synaptic vesicle endocytosis|axon extension|modulation of chemical synaptic transmission|synapse organization|cell adhesion molecule binding|positive regulation of synapse assembly|positive regulation of synaptic transmission, glutamatergic|rhythmic synaptic transmission|excitatory synapse|inhibitory postsynaptic potential|vocalization behavior|spanning component of membrane|postsynaptic membrane assembly|presynaptic membrane assembly|scaffold protein binding|presynapse|symmetric, GABA-ergic, inhibitory synapse|asymmetric, glutamatergic, excitatory synapse|presynapse assembly|integral component of postsynaptic membrane|positive regulation of excitatory postsynaptic potential|positive regulation of AMPA receptor activity" hsa04514 Cell adhesion molecules NLK 540.1716058 492.1157665 588.2274451 1.195302986 0.257376359 0.339245679 1 7.385633855 8.6803444 51701 nemo like kinase "GO:0000165,GO:0000287,GO:0004672,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006468,GO:0007179,GO:0007223,GO:0008134,GO:0010468,GO:0018107,GO:0030178,GO:0031625,GO:0035556,GO:0042169,GO:0042501,GO:0046777,GO:0050821" "MAPK cascade|magnesium ion binding|protein kinase activity|protein serine/threonine kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|protein phosphorylation|transforming growth factor beta receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|transcription factor binding|regulation of gene expression|peptidyl-threonine phosphorylation|negative regulation of Wnt signaling pathway|ubiquitin protein ligase binding|intracellular signal transduction|SH2 domain binding|serine phosphorylation of STAT protein|protein autophosphorylation|protein stabilization" "hsa04010,hsa04068,hsa04310,hsa04520" MAPK signaling pathway|FoxO signaling pathway|Wnt signaling pathway|Adherens junction NLN 1528.134405 1549.176271 1507.092539 0.972834768 -0.039733304 0.870243671 1 19.86465409 19.00164802 57486 neurolysin "GO:0004222,GO:0005576,GO:0005758,GO:0005886,GO:0006111,GO:0006508,GO:0006518,GO:0042277,GO:0046872,GO:1902809" metalloendopeptidase activity|extracellular region|mitochondrial intermembrane space|plasma membrane|regulation of gluconeogenesis|proteolysis|peptide metabolic process|peptide binding|metal ion binding|regulation of skeletal muscle fiber differentiation hsa04614 Renin-angiotensin system NLRC4 4.042768641 5.202069413 2.883467868 0.554292463 -0.851280704 0.745112452 1 0.076713148 0.04180998 58484 NLR family CARD domain containing 4 "GO:0000287,GO:0002218,GO:0005515,GO:0005524,GO:0005829,GO:0006915,GO:0006919,GO:0006954,GO:0010954,GO:0016045,GO:0032731,GO:0042742,GO:0042802,GO:0042803,GO:0042981,GO:0043065,GO:0045087,GO:0051092,GO:0051260,GO:0061133,GO:0070269,GO:0072557,GO:0089720,GO:0097202" magnesium ion binding|activation of innate immune response|protein binding|ATP binding|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|positive regulation of protein processing|detection of bacterium|positive regulation of interleukin-1 beta production|defense response to bacterium|identical protein binding|protein homodimerization activity|regulation of apoptotic process|positive regulation of apoptotic process|innate immune response|positive regulation of NF-kappaB transcription factor activity|protein homooligomerization|endopeptidase activator activity|pyroptosis|IPAF inflammasome complex|caspase binding|activation of cysteine-type endopeptidase activity "hsa04621,hsa05131,hsa05132,hsa05134,hsa05135" NOD-like receptor signaling pathway|Shigellosis|Salmonella infection|Legionellosis|Yersinia infection NLRC5 180.5275143 222.6485709 138.4064577 0.621636407 -0.685857095 0.069384114 1 1.482883442 0.90638902 84166 NLR family CARD domain containing 5 "GO:0000978,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0009617,GO:0032088,GO:0032480,GO:0035556,GO:0043549,GO:0045087,GO:0045345,GO:0045944,GO:0051607,GO:0060335,GO:0060339,GO:0060340" RNA polymerase II cis-regulatory region sequence-specific DNA binding|protein binding|ATP binding|nucleus|cytoplasm|centrosome|cytosol|response to bacterium|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|intracellular signal transduction|regulation of kinase activity|innate immune response|positive regulation of MHC class I biosynthetic process|positive regulation of transcription by RNA polymerase II|defense response to virus|positive regulation of interferon-gamma-mediated signaling pathway|negative regulation of type I interferon-mediated signaling pathway|positive regulation of type I interferon-mediated signaling pathway NLRP1 1901.093828 2168.222531 1633.965125 0.753596599 -0.408135641 0.084856677 1 18.9726269 14.05845434 22861 NLR family pyrin domain containing 1 "GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006915,GO:0006919,GO:0006954,GO:0008656,GO:0016032,GO:0019899,GO:0019904,GO:0032495,GO:0032731,GO:0042742,GO:0042981,GO:0050727,GO:0051402,GO:0051607,GO:0061702,GO:0070269,GO:0072558,GO:0097264,GO:0140374,GO:1904784" protein binding|ATP binding|nucleus|nucleoplasm|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|cysteine-type endopeptidase activator activity involved in apoptotic process|viral process|enzyme binding|protein domain specific binding|response to muramyl dipeptide|positive regulation of interleukin-1 beta production|defense response to bacterium|regulation of apoptotic process|regulation of inflammatory response|neuron apoptotic process|defense response to virus|inflammasome complex|pyroptosis|NLRP1 inflammasome complex|self proteolysis|antiviral innate immune response|NLRP1 inflammasome complex assembly hsa04621 NOD-like receptor signaling pathway NLRP10 125.5044654 115.485941 135.5229898 1.173502061 0.230820376 0.603733153 1 1.383140129 1.595957115 338322 NLR family pyrin domain containing 10 "GO:0002250,GO:0002827,GO:0003924,GO:0005524,GO:0005737,GO:0006954,GO:0016887,GO:0019897,GO:0032730,GO:0032755,GO:0032757,GO:0045087,GO:0050729,GO:0050829,GO:0050832,GO:1900426,GO:2000318" adaptive immune response|positive regulation of T-helper 1 type immune response|GTPase activity|ATP binding|cytoplasm|inflammatory response|ATPase activity|extrinsic component of plasma membrane|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|innate immune response|positive regulation of inflammatory response|defense response to Gram-negative bacterium|defense response to fungus|positive regulation of defense response to bacterium|positive regulation of T-helper 17 type immune response NLRP14 6.524916457 7.282897178 5.766935736 0.791846376 -0.336707531 0.922510643 1 0.096135255 0.074850516 338323 NLR family pyrin domain containing 14 "GO:0005524,GO:0005737,GO:0007275,GO:0007283,GO:0030154" ATP binding|cytoplasm|multicellular organism development|spermatogenesis|cell differentiation NLRP3 520.8994112 415.1251392 626.6736833 1.509601863 0.594168108 0.028313238 0.877967194 5.278643248 7.835305118 114548 NLR family pyrin domain containing 3 "GO:0000139,GO:0002523,GO:0002674,GO:0002830,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0006915,GO:0006952,GO:0006954,GO:0007165,GO:0008134,GO:0009595,GO:0014070,GO:0016579,GO:0032088,GO:0032691,GO:0032731,GO:0032753,GO:0042802,GO:0042834,GO:0043280,GO:0043565,GO:0045087,GO:0045471,GO:0045630,GO:0045944,GO:0050728,GO:0051092,GO:0071222,GO:0072559,GO:1901223,GO:2000553" Golgi membrane|leukocyte migration involved in inflammatory response|negative regulation of acute inflammatory response|positive regulation of type 2 immune response|protein binding|ATP binding|extracellular region|nucleus|cytoplasm|endoplasmic reticulum|cytosol|apoptotic process|defense response|inflammatory response|signal transduction|transcription factor binding|detection of biotic stimulus|response to organic cyclic compound|protein deubiquitination|negative regulation of NF-kappaB transcription factor activity|negative regulation of interleukin-1 beta production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-4 production|identical protein binding|peptidoglycan binding|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|sequence-specific DNA binding|innate immune response|response to ethanol|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription by RNA polymerase II|negative regulation of inflammatory response|positive regulation of NF-kappaB transcription factor activity|cellular response to lipopolysaccharide|NLRP3 inflammasome complex|negative regulation of NIK/NF-kappaB signaling|positive regulation of T-helper 2 cell cytokine production "hsa04217,hsa04621,hsa04625,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05164,hsa05171" Necroptosis|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Influenza A|Coronavirus disease - COVID-19 NLRX1 325.8941926 342.2961674 309.4922178 0.904165011 -0.145342006 0.641747933 1 4.132032875 3.673521986 79671 NLR family member X1 "GO:0005515,GO:0005524,GO:0005739,GO:0005741,GO:0005886,GO:0016032,GO:0030054,GO:0032480,GO:0032688,GO:0032715,GO:0035556,GO:0039536,GO:0043124,GO:0045087,GO:0045824,GO:0050728" protein binding|ATP binding|mitochondrion|mitochondrial outer membrane|plasma membrane|viral process|cell junction|negative regulation of type I interferon production|negative regulation of interferon-beta production|negative regulation of interleukin-6 production|intracellular signal transduction|negative regulation of RIG-I signaling pathway|negative regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|negative regulation of innate immune response|negative regulation of inflammatory response "hsa04621,hsa04622,hsa05164" NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Influenza A NMB 87.10288653 104.0413883 70.16438479 0.674389163 -0.568346741 0.248695261 1 3.985999764 2.643133081 4828 neuromedin B "GO:0005179,GO:0005184,GO:0005515,GO:0005576,GO:0007165,GO:0007186,GO:0007204,GO:0007218,GO:0007267,GO:0008284,GO:0031710,GO:0042593,GO:0043005,GO:0046887,GO:0046888,GO:0050482" hormone activity|neuropeptide hormone activity|protein binding|extracellular region|signal transduction|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|cell-cell signaling|positive regulation of cell population proliferation|neuromedin B receptor binding|glucose homeostasis|neuron projection|positive regulation of hormone secretion|negative regulation of hormone secretion|arachidonic acid secretion hsa04080 Neuroactive ligand-receptor interaction NMD3 1673.480962 1718.763734 1628.198189 0.947307741 -0.078094922 0.744199195 1 22.30178982 20.77313211 51068 NMD3 ribosome export adaptor "GO:0000055,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0016020,GO:0030674,GO:0032092,GO:0043023,GO:1902680,GO:1904751" ribosomal large subunit export from nucleus|RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|membrane|protein-macromolecule adaptor activity|positive regulation of protein binding|ribosomal large subunit binding|positive regulation of RNA biosynthetic process|positive regulation of protein localization to nucleolus "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport NME1 285.5061352 291.3158871 279.6963832 0.960113731 -0.058722784 0.865253512 1 15.07952811 14.23579123 4830 NME/NM23 nucleoside diphosphate kinase 1 "GO:0000287,GO:0000977,GO:0002762,GO:0003697,GO:0003723,GO:0004536,GO:0004550,GO:0005515,GO:0005524,GO:0005525,GO:0005634,GO:0005737,GO:0005741,GO:0005813,GO:0005829,GO:0005882,GO:0006165,GO:0006183,GO:0006228,GO:0006241,GO:0006259,GO:0006897,GO:0007595,GO:0008285,GO:0010629,GO:0010976,GO:0014075,GO:0015949,GO:0016020,GO:0019215,GO:0019899,GO:0021766,GO:0030154,GO:0032587,GO:0033574,GO:0035690,GO:0042802,GO:0042981,GO:0043015,GO:0043024,GO:0043388,GO:0048471,GO:0050679,GO:0051591,GO:0070062,GO:0071333,GO:0071398" magnesium ion binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|negative regulation of myeloid leukocyte differentiation|single-stranded DNA binding|RNA binding|deoxyribonuclease activity|nucleoside diphosphate kinase activity|protein binding|ATP binding|GTP binding|nucleus|cytoplasm|mitochondrial outer membrane|centrosome|cytosol|intermediate filament|nucleoside diphosphate phosphorylation|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|DNA metabolic process|endocytosis|lactation|negative regulation of cell population proliferation|negative regulation of gene expression|positive regulation of neuron projection development|response to amine|nucleobase-containing small molecule interconversion|membrane|intermediate filament binding|enzyme binding|hippocampus development|cell differentiation|ruffle membrane|response to testosterone|cellular response to drug|identical protein binding|regulation of apoptotic process|gamma-tubulin binding|ribosomal small subunit binding|positive regulation of DNA binding|perinuclear region of cytoplasm|positive regulation of epithelial cell proliferation|response to cAMP|extracellular exosome|cellular response to glucose stimulus|cellular response to fatty acid "hsa00230,hsa00240,hsa00983" Purine metabolism|Pyrimidine metabolism|Drug metabolism - other enzymes NME2 6.604174384 9.363724944 3.844623824 0.41058701 -1.284240111 0.3924594 1 0.497733855 0.200943316 4831 NME/NM23 nucleoside diphosphate kinase 2 "GO:0001726,GO:0002762,GO:0003677,GO:0003713,GO:0004550,GO:0004673,GO:0004674,GO:0005504,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005882,GO:0005925,GO:0006165,GO:0006183,GO:0006228,GO:0006241,GO:0007155,GO:0007189,GO:0007229,GO:0008144,GO:0009142,GO:0010976,GO:0015949,GO:0018106,GO:0019003,GO:0019215,GO:0019899,GO:0030027,GO:0031966,GO:0034599,GO:0034774,GO:0042802,GO:0042981,GO:0043066,GO:0043312,GO:0045618,GO:0045682,GO:0045893,GO:0045944,GO:0046777,GO:0046872,GO:0048471,GO:0050679,GO:0051880,GO:0060416,GO:0070062,GO:0071333,GO:0071398,GO:0071944,GO:1904813" "ruffle|negative regulation of myeloid leukocyte differentiation|DNA binding|transcription coactivator activity|nucleoside diphosphate kinase activity|protein histidine kinase activity|protein serine/threonine kinase activity|fatty acid binding|protein binding|ATP binding|extracellular region|nucleus|cytoplasm|cytosol|intermediate filament|focal adhesion|nucleoside diphosphate phosphorylation|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|cell adhesion|adenylate cyclase-activating G protein-coupled receptor signaling pathway|integrin-mediated signaling pathway|drug binding|nucleoside triphosphate biosynthetic process|positive regulation of neuron projection development|nucleobase-containing small molecule interconversion|peptidyl-histidine phosphorylation|GDP binding|intermediate filament binding|enzyme binding|lamellipodium|mitochondrial membrane|cellular response to oxidative stress|secretory granule lumen|identical protein binding|regulation of apoptotic process|negative regulation of apoptotic process|neutrophil degranulation|positive regulation of keratinocyte differentiation|regulation of epidermis development|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein autophosphorylation|metal ion binding|perinuclear region of cytoplasm|positive regulation of epithelial cell proliferation|G-quadruplex DNA binding|response to growth hormone|extracellular exosome|cellular response to glucose stimulus|cellular response to fatty acid|cell periphery|ficolin-1-rich granule lumen" "hsa00230,hsa00240,hsa00983" Purine metabolism|Pyrimidine metabolism|Drug metabolism - other enzymes NME3 317.7690264 330.8516147 304.686438 0.920915675 -0.118859035 0.707890762 1 20.55523003 18.61287176 4832 NME/NM23 nucleoside diphosphate kinase 3 "GO:0004550,GO:0005515,GO:0005524,GO:0005829,GO:0006165,GO:0006183,GO:0006228,GO:0006241,GO:0006915,GO:0015949,GO:0046872" nucleoside diphosphate kinase activity|protein binding|ATP binding|cytosol|nucleoside diphosphate phosphorylation|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|apoptotic process|nucleobase-containing small molecule interconversion|metal ion binding "hsa00230,hsa00240,hsa00983" Purine metabolism|Pyrimidine metabolism|Drug metabolism - other enzymes NME4 1731.006895 1677.147179 1784.86661 1.064227775 0.089806961 0.706762076 1 43.09401178 45.09440841 4833 NME/NM23 nucleoside diphosphate kinase 4 "GO:0004550,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0005758,GO:0005759,GO:0006165,GO:0006183,GO:0006228,GO:0006241,GO:0006869,GO:0009116,GO:0015949,GO:0046872,GO:1901612" nucleoside diphosphate kinase activity|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|nucleoside diphosphate phosphorylation|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|lipid transport|nucleoside metabolic process|nucleobase-containing small molecule interconversion|metal ion binding|cardiolipin binding "hsa00230,hsa00240,hsa00983" Purine metabolism|Pyrimidine metabolism|Drug metabolism - other enzymes NME6 587.0197986 611.763363 562.2762343 0.9191074 -0.12169464 0.648869002 1 5.038377517 4.553319727 10201 NME/NM23 nucleoside diphosphate kinase 6 "GO:0004550,GO:0005515,GO:0005524,GO:0005739,GO:0006165,GO:0006183,GO:0006228,GO:0006241,GO:0006915,GO:0030308,GO:0045839,GO:0046872" nucleoside diphosphate kinase activity|protein binding|ATP binding|mitochondrion|nucleoside diphosphate phosphorylation|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|apoptotic process|negative regulation of cell growth|negative regulation of mitotic nuclear division|metal ion binding "hsa00230,hsa00240,hsa00983" Purine metabolism|Pyrimidine metabolism|Drug metabolism - other enzymes NME7 459.5986661 382.8723088 536.3250234 1.400793453 0.486244246 0.081271593 1 13.88124418 19.11937431 29922 NME/NM23 family member 7 "GO:0004550,GO:0005515,GO:0005524,GO:0005813,GO:0005829,GO:0006165,GO:0006183,GO:0006228,GO:0006241,GO:0046872" nucleoside diphosphate kinase activity|protein binding|ATP binding|centrosome|cytosol|nucleoside diphosphate phosphorylation|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|metal ion binding "hsa00230,hsa00240,hsa00983" Purine metabolism|Pyrimidine metabolism|Drug metabolism - other enzymes NME9 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.016083319 0.009739649 347736 NME/NM23 family member 9 "GO:0004550,GO:0005737,GO:0005856,GO:0006165,GO:0006183,GO:0006228,GO:0006241" nucleoside diphosphate kinase activity|cytoplasm|cytoskeleton|nucleoside diphosphate phosphorylation|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process NMI 261.1551741 295.4775427 226.8328056 0.76768205 -0.38141918 0.248546942 1 9.668358913 7.298024695 9111 N-myc and STAT interactor "GO:0002281,GO:0003712,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006366,GO:0007259,GO:0008285,GO:0009615,GO:0016020,GO:0032687,GO:0032688,GO:0034142,GO:0042802,GO:0045089,GO:0045824,GO:0050729,GO:0060333,GO:1901223,GO:1901224,GO:1902524" "macrophage activation involved in immune response|transcription coregulator activity|protein binding|extracellular space|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|transcription by RNA polymerase II|receptor signaling pathway via JAK-STAT|negative regulation of cell population proliferation|response to virus|membrane|negative regulation of interferon-alpha production|negative regulation of interferon-beta production|toll-like receptor 4 signaling pathway|identical protein binding|positive regulation of innate immune response|negative regulation of innate immune response|positive regulation of inflammatory response|interferon-gamma-mediated signaling pathway|negative regulation of NIK/NF-kappaB signaling|positive regulation of NIK/NF-kappaB signaling|positive regulation of protein K48-linked ubiquitination" NMNAT1 241.7490015 252.8205735 230.6774294 0.912415577 -0.132237018 0.705099845 1 4.942333092 4.434001966 64802 nicotinamide nucleotide adenylyltransferase 1 "GO:0000309,GO:0004515,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0009165,GO:0009435,GO:0009611,GO:0016604,GO:0019674,GO:0042802,GO:0043410,GO:0043524,GO:1902511,GO:1990966" nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|nucleotide biosynthetic process|NAD biosynthetic process|response to wounding|nuclear body|NAD metabolic process|identical protein binding|positive regulation of MAPK cascade|negative regulation of neuron apoptotic process|negative regulation of apoptotic DNA fragmentation|ATP generation from poly-ADP-D-ribose hsa00760 Nicotinate and nicotinamide metabolism NMNAT2 1425.243486 1169.425204 1681.061767 1.437511147 0.523573144 0.028816918 0.88444427 10.599537 14.98198282 23057 nicotinamide nucleotide adenylyltransferase 2 "GO:0000139,GO:0000309,GO:0004515,GO:0005524,GO:0005770,GO:0005794,GO:0005802,GO:0005829,GO:0009165,GO:0009435,GO:0019674,GO:0030424,GO:0030659,GO:0045202" Golgi membrane|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity|ATP binding|late endosome|Golgi apparatus|trans-Golgi network|cytosol|nucleotide biosynthetic process|NAD biosynthetic process|NAD metabolic process|axon|cytoplasmic vesicle membrane|synapse hsa00760 Nicotinate and nicotinamide metabolism NMRAL1 814.0243682 881.2305586 746.8181778 0.847471948 -0.238762481 0.342358455 1 19.62840371 16.35616533 57407 NmrA like redox sensor 1 "GO:0000050,GO:0005515,GO:0005654,GO:0005829,GO:0042802,GO:0048471" urea cycle|protein binding|nucleoplasm|cytosol|identical protein binding|perinuclear region of cytoplasm NMRK1 411.4962089 394.3168615 428.6755564 1.087134734 0.120530752 0.680293662 1 5.969919482 6.38150368 54981 nicotinamide riboside kinase 1 "GO:0005515,GO:0005524,GO:0005829,GO:0009435,GO:0016301,GO:0016310,GO:0019674,GO:0046872,GO:0050262,GO:0061769" protein binding|ATP binding|cytosol|NAD biosynthetic process|kinase activity|phosphorylation|NAD metabolic process|metal ion binding|ribosylnicotinamide kinase activity|ribosylnicotinate kinase activity hsa00760 Nicotinate and nicotinamide metabolism NMT1 3149.451248 3122.282062 3176.620435 1.017403416 0.024891843 0.917666891 1 34.13858945 34.15151253 4836 N-myristoyltransferase 1 "GO:0001701,GO:0004379,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006499,GO:0018008,GO:0019107,GO:0019898,GO:0022400,GO:0042180,GO:1900740" in utero embryonic development|glycylpeptide N-tetradecanoyltransferase activity|protein binding|cytoplasm|mitochondrion|cytosol|plasma membrane|N-terminal protein myristoylation|N-terminal peptidyl-glycine N-myristoylation|myristoyltransferase activity|extrinsic component of membrane|regulation of rhodopsin mediated signaling pathway|cellular ketone metabolic process|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway NMT2 3307.383994 2966.219979 3648.548009 1.230032848 0.298696843 0.207810911 1 28.10255789 33.98863623 9397 N-myristoyltransferase 2 "GO:0004379,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0018008,GO:0019898,GO:0022400,GO:0043657,GO:0075733" glycylpeptide N-tetradecanoyltransferase activity|protein binding|cytoplasm|Golgi apparatus|cytosol|plasma membrane|N-terminal peptidyl-glycine N-myristoylation|extrinsic component of membrane|regulation of rhodopsin mediated signaling pathway|host cell|intracellular transport of virus NMU 320.4593798 313.1645787 327.754181 1.046587652 0.065693142 0.840722997 1 12.62312537 12.99013548 10874 neuromedin U "GO:0001659,GO:0001696,GO:0003084,GO:0005102,GO:0005515,GO:0005576,GO:0007186,GO:0007204,GO:0007218,GO:0009648,GO:0010460,GO:0019233,GO:0031652,GO:0031839,GO:0031840,GO:0042755,GO:0042922,GO:0043195,GO:0045187,GO:0045987,GO:0050806,GO:0060455,GO:0097009,GO:0120061,GO:0120069,GO:1902722,GO:1903999,GO:1904058,GO:2000821" "temperature homeostasis|gastric acid secretion|positive regulation of systemic arterial blood pressure|signaling receptor binding|protein binding|extracellular region|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|photoperiodism|positive regulation of heart rate|sensory perception of pain|positive regulation of heat generation|type 1 neuromedin U receptor binding|type 2 neuromedin U receptor binding|eating behavior|neuromedin U receptor binding|terminal bouton|regulation of circadian sleep/wake cycle, sleep|positive regulation of smooth muscle contraction|positive regulation of synaptic transmission|negative regulation of gastric acid secretion|energy homeostasis|negative regulation of gastric emptying|positive regulation of stomach fundus smooth muscle contraction|positive regulation of prolactin secretion|negative regulation of eating behavior|positive regulation of sensory perception of pain|regulation of grooming behavior" hsa04080 Neuroactive ligand-receptor interaction NNMT 496.2358345 499.3986637 493.0730054 0.98733345 -0.01839069 0.954465339 1 11.68946878 11.34827378 4837 nicotinamide N-methyltransferase "GO:0005829,GO:0008112,GO:0008170,GO:0010243,GO:0030760,GO:0031100,GO:0032259,GO:0034356,GO:0042493" cytosol|nicotinamide N-methyltransferase activity|N-methyltransferase activity|response to organonitrogen compound|pyridine N-methyltransferase activity|animal organ regeneration|methylation|NAD biosynthesis via nicotinamide riboside salvage pathway|response to drug hsa00760 Nicotinate and nicotinamide metabolism NNT 1985.354719 1970.543894 2000.165544 1.015032221 0.021525524 0.929742288 1 15.10547341 15.07597289 23530 nicotinamide nucleotide transhydrogenase "GO:0001933,GO:0003957,GO:0005739,GO:0005743,GO:0005746,GO:0006099,GO:0006740,GO:0008746,GO:0010918,GO:0016020,GO:0016021,GO:0032364,GO:0033273,GO:0043066,GO:0045454,GO:0050661,GO:0051287,GO:0055114,GO:0072593,GO:0098869,GO:1902600,GO:1903285" negative regulation of protein phosphorylation|NAD(P)+ transhydrogenase (B-specific) activity|mitochondrion|mitochondrial inner membrane|mitochondrial respirasome|tricarboxylic acid cycle|NADPH regeneration|NAD(P)+ transhydrogenase activity|positive regulation of mitochondrial membrane potential|membrane|integral component of membrane|oxygen homeostasis|response to vitamin|negative regulation of apoptotic process|cell redox homeostasis|NADP binding|NAD binding|oxidation-reduction process|reactive oxygen species metabolic process|cellular oxidant detoxification|proton transmembrane transport|positive regulation of hydrogen peroxide catabolic process hsa00760 Nicotinate and nicotinamide metabolism NOA1 930.1852303 928.0491833 932.3212773 1.004603306 0.006625927 0.983564147 1 22.33015294 22.0575605 84273 nitric oxide associated 1 "GO:0003723,GO:0005515,GO:0005525,GO:0005739,GO:0006915,GO:0010941,GO:0031314,GO:0032543,GO:0043457" RNA binding|protein binding|GTP binding|mitochondrion|apoptotic process|regulation of cell death|extrinsic component of mitochondrial inner membrane|mitochondrial translation|regulation of cellular respiration NOB1 2080.572711 2110.999768 2050.145654 0.971172847 -0.042200009 0.860243184 1 65.65278424 62.69326075 28987 NIN1 (RPN12) binding protein 1 homolog "GO:0000469,GO:0004521,GO:0005515,GO:0005654,GO:0005829,GO:0006364,GO:0007601,GO:0030490,GO:0030688,GO:0046872,GO:0090502" "cleavage involved in rRNA processing|endoribonuclease activity|protein binding|nucleoplasm|cytosol|rRNA processing|visual perception|maturation of SSU-rRNA|preribosome, small subunit precursor|metal ion binding|RNA phosphodiester bond hydrolysis, endonucleolytic" hsa03008 Ribosome biogenesis in eukaryotes NOC2L 2269.439242 2211.919914 2326.958569 1.052008508 0.073146373 0.758352458 1 42.81686634 44.28996224 26155 NOC2 like nucleolar associated transcriptional repressor "GO:0000122,GO:0002903,GO:0003682,GO:0003714,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005829,GO:0006915,GO:0030690,GO:0030691,GO:0031491,GO:0031497,GO:0034644,GO:0035067,GO:0042273,GO:0042393,GO:0070491,GO:1901796,GO:2001243" negative regulation of transcription by RNA polymerase II|negative regulation of B cell apoptotic process|chromatin binding|transcription corepressor activity|RNA binding|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|cytosol|apoptotic process|Noc1p-Noc2p complex|Noc2p-Noc3p complex|nucleosome binding|chromatin assembly|cellular response to UV|negative regulation of histone acetylation|ribosomal large subunit biogenesis|histone binding|repressing transcription factor binding|regulation of signal transduction by p53 class mediator|negative regulation of intrinsic apoptotic signaling pathway NOC3L 2415.59224 2566.701048 2264.483432 0.882254454 -0.180733286 0.444830713 1 34.2793087 29.73699592 64318 NOC3 like DNA replication regulator "GO:0003682,GO:0003723,GO:0005654,GO:0005730,GO:0005739,GO:0006270,GO:0016607,GO:0045444" chromatin binding|RNA binding|nucleoplasm|nucleolus|mitochondrion|DNA replication initiation|nuclear speck|fat cell differentiation NOC4L 356.7549788 382.8723088 330.6376489 0.863571591 -0.211612311 0.481970911 1 12.1265231 10.29688409 79050 nucleolar complex associated 4 homolog "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0016021,GO:0030692,GO:0031965,GO:0032040" RNA binding|protein binding|nucleoplasm|nucleolus|rRNA processing|integral component of membrane|Noc4p-Nop14p complex|nuclear membrane|small-subunit processome NOCT 245.3111921 258.0226429 232.5997414 0.901470269 -0.149648183 0.665009832 1 7.018447618 6.221049394 25819 nocturnin "GO:0000175,GO:0000290,GO:0000932,GO:0003729,GO:0004535,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0006366,GO:0006739,GO:0007623,GO:0009991,GO:0010629,GO:0016311,GO:0019178,GO:0032496,GO:0032922,GO:0033962,GO:0042752,GO:0045600,GO:0045668,GO:0045995,GO:0046872,GO:0048255,GO:0048471,GO:0090503,GO:0102757" "3'-5'-exoribonuclease activity|deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|mRNA binding|poly(A)-specific ribonuclease activity|nucleus|nucleoplasm|cytoplasm|mitochondrion|transcription by RNA polymerase II|NADP metabolic process|circadian rhythm|response to extracellular stimulus|negative regulation of gene expression|dephosphorylation|NADP phosphatase activity|response to lipopolysaccharide|circadian regulation of gene expression|P-body assembly|regulation of circadian rhythm|positive regulation of fat cell differentiation|negative regulation of osteoblast differentiation|regulation of embryonic development|metal ion binding|mRNA stabilization|perinuclear region of cytoplasm|RNA phosphodiester bond hydrolysis, exonucleolytic|NADPH phosphatase activity" NOD1 281.7162316 254.9014012 308.5310619 1.210393746 0.275476438 0.395355119 1 2.406016855 2.863495566 10392 nucleotide binding oligomerization domain containing 1 "GO:0000187,GO:0002221,GO:0002606,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006915,GO:0006919,GO:0006952,GO:0006954,GO:0007165,GO:0007254,GO:0008656,GO:0009595,GO:0010942,GO:0016045,GO:0016323,GO:0016324,GO:0032731,GO:0032755,GO:0032757,GO:0032760,GO:0035556,GO:0038187,GO:0042742,GO:0042802,GO:0042803,GO:0042834,GO:0042981,GO:0043123,GO:0043280,GO:0044877,GO:0045087,GO:0045335,GO:0046330,GO:0046658,GO:0050700,GO:0050830,GO:0051000,GO:0051092,GO:0070374,GO:0070423,GO:0070498,GO:0071225,GO:1901224,GO:1904417" activation of MAPK activity|pattern recognition receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|protein binding|ATP binding|cytoplasm|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|defense response|inflammatory response|signal transduction|JNK cascade|cysteine-type endopeptidase activator activity involved in apoptotic process|detection of biotic stimulus|positive regulation of cell death|detection of bacterium|basolateral plasma membrane|apical plasma membrane|positive regulation of interleukin-1 beta production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|intracellular signal transduction|pattern recognition receptor activity|defense response to bacterium|identical protein binding|protein homodimerization activity|peptidoglycan binding|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein-containing complex binding|innate immune response|phagocytic vesicle|positive regulation of JNK cascade|anchored component of plasma membrane|CARD domain binding|defense response to Gram-positive bacterium|positive regulation of nitric-oxide synthase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of ERK1 and ERK2 cascade|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|cellular response to muramyl dipeptide|positive regulation of NIK/NF-kappaB signaling|positive regulation of xenophagy "hsa04621,hsa05120,hsa05131,hsa05132,hsa05133" NOD-like receptor signaling pathway|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Salmonella infection|Pertussis NOD2 15.25457799 9.363724944 21.14543103 2.258228553 1.175191507 0.22689388 1 0.060433522 0.134189018 64127 nucleotide binding oligomerization domain containing 2 "GO:0000187,GO:0002221,GO:0002227,GO:0002253,GO:0002367,GO:0002606,GO:0002710,GO:0002732,GO:0002830,GO:0002862,GO:0002925,GO:0003779,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005794,GO:0005829,GO:0005856,GO:0005886,GO:0006952,GO:0006965,GO:0007254,GO:0007584,GO:0009595,GO:0009986,GO:0016045,GO:0016323,GO:0019899,GO:0019901,GO:0030277,GO:0030544,GO:0031982,GO:0032088,GO:0032495,GO:0032498,GO:0032500,GO:0032689,GO:0032695,GO:0032701,GO:0032703,GO:0032720,GO:0032731,GO:0032733,GO:0032735,GO:0032740,GO:0032755,GO:0032757,GO:0032760,GO:0032874,GO:0032991,GO:0034136,GO:0035556,GO:0038187,GO:0042742,GO:0042834,GO:0043123,GO:0043330,GO:0043406,GO:0043552,GO:0044877,GO:0045087,GO:0045089,GO:0045335,GO:0045747,GO:0045944,GO:0046330,GO:0046645,GO:0046658,GO:0050679,GO:0050700,GO:0050727,GO:0050731,GO:0050766,GO:0050830,GO:0050871,GO:0051092,GO:0051353,GO:0051770,GO:0051879,GO:0060585,GO:0070374,GO:0070423,GO:0070431,GO:0070498,GO:0071222,GO:0071224,GO:0071225,GO:0071407,GO:0071639,GO:0090022,GO:1900017,GO:1901224,GO:1902523,GO:1904417,GO:2000110,GO:2000363" activation of MAPK activity|pattern recognition receptor signaling pathway|innate immune response in mucosa|activation of immune response|cytokine production involved in immune response|positive regulation of dendritic cell antigen processing and presentation|negative regulation of T cell mediated immunity|positive regulation of dendritic cell cytokine production|positive regulation of type 2 immune response|negative regulation of inflammatory response to antigenic stimulus|positive regulation of humoral immune response mediated by circulating immunoglobulin|actin binding|protein binding|ATP binding|cytoplasm|mitochondrion|Golgi apparatus|cytosol|cytoskeleton|plasma membrane|defense response|positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria|JNK cascade|response to nutrient|detection of biotic stimulus|cell surface|detection of bacterium|basolateral plasma membrane|enzyme binding|protein kinase binding|maintenance of gastrointestinal epithelium|Hsp70 protein binding|vesicle|negative regulation of NF-kappaB transcription factor activity|response to muramyl dipeptide|detection of muramyl dipeptide|muramyl dipeptide binding|negative regulation of interferon-gamma production|negative regulation of interleukin-12 production|negative regulation of interleukin-18 production|negative regulation of interleukin-2 production|negative regulation of tumor necrosis factor production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|positive regulation of stress-activated MAPK cascade|protein-containing complex|negative regulation of toll-like receptor 2 signaling pathway|intracellular signal transduction|pattern recognition receptor activity|defense response to bacterium|peptidoglycan binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to exogenous dsRNA|positive regulation of MAP kinase activity|positive regulation of phosphatidylinositol 3-kinase activity|protein-containing complex binding|innate immune response|positive regulation of innate immune response|phagocytic vesicle|positive regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|positive regulation of gamma-delta T cell activation|anchored component of plasma membrane|positive regulation of epithelial cell proliferation|CARD domain binding|regulation of inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of phagocytosis|defense response to Gram-positive bacterium|positive regulation of B cell activation|positive regulation of NF-kappaB transcription factor activity|positive regulation of oxidoreductase activity|positive regulation of nitric-oxide synthase biosynthetic process|Hsp90 protein binding|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of ERK1 and ERK2 cascade|nucleotide-binding oligomerization domain containing signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|interleukin-1-mediated signaling pathway|cellular response to lipopolysaccharide|cellular response to peptidoglycan|cellular response to muramyl dipeptide|cellular response to organic cyclic compound|positive regulation of monocyte chemotactic protein-1 production|regulation of neutrophil chemotaxis|positive regulation of cytokine production involved in inflammatory response|positive regulation of NIK/NF-kappaB signaling|positive regulation of protein K63-linked ubiquitination|positive regulation of xenophagy|negative regulation of macrophage apoptotic process|positive regulation of prostaglandin-E synthase activity "hsa04621,hsa04668,hsa05152,hsa05321" NOD-like receptor signaling pathway|TNF signaling pathway|Tuberculosis|Inflammatory bowel disease NOG 454.5349909 426.5696919 482.5002899 1.13111714 0.177748345 0.52857777 1 11.90028252 13.23536839 9241 noggin "GO:0000122,GO:0001501,GO:0001649,GO:0001701,GO:0001706,GO:0001707,GO:0001837,GO:0001839,GO:0001843,GO:0003149,GO:0003151,GO:0003203,GO:0003223,GO:0005515,GO:0005576,GO:0005615,GO:0007399,GO:0008045,GO:0009953,GO:0010628,GO:0019955,GO:0021510,GO:0021533,GO:0021983,GO:0030336,GO:0030509,GO:0030514,GO:0035019,GO:0042060,GO:0042474,GO:0042733,GO:0042803,GO:0045668,GO:0045944,GO:0048318,GO:0048570,GO:0048706,GO:0048712,GO:0050679,GO:0051216,GO:0055009,GO:0060044,GO:0060173,GO:0060272,GO:0060302,GO:0060325,GO:0060394,GO:0060412,GO:0060425,GO:0060513,GO:0060676,GO:0060825,GO:0061037,GO:0061053,GO:0061312,GO:0061384,GO:0061626,GO:0090090,GO:0090190,GO:0090193,GO:1905006,GO:2000313,GO:2001234" negative regulation of transcription by RNA polymerase II|skeletal system development|osteoblast differentiation|in utero embryonic development|endoderm formation|mesoderm formation|epithelial to mesenchymal transition|neural plate morphogenesis|neural tube closure|membranous septum morphogenesis|outflow tract morphogenesis|endocardial cushion morphogenesis|ventricular compact myocardium morphogenesis|protein binding|extracellular region|extracellular space|nervous system development|motor neuron axon guidance|dorsal/ventral pattern formation|positive regulation of gene expression|cytokine binding|spinal cord development|cell differentiation in hindbrain|pituitary gland development|negative regulation of cell migration|BMP signaling pathway|negative regulation of BMP signaling pathway|somatic stem cell population maintenance|wound healing|middle ear morphogenesis|embryonic digit morphogenesis|protein homodimerization activity|negative regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|axial mesoderm development|notochord morphogenesis|embryonic skeletal system development|negative regulation of astrocyte differentiation|positive regulation of epithelial cell proliferation|cartilage development|atrial cardiac muscle tissue morphogenesis|negative regulation of cardiac muscle cell proliferation|limb development|embryonic skeletal joint morphogenesis|negative regulation of cytokine activity|face morphogenesis|negative regulation of pathway-restricted SMAD protein phosphorylation|ventricular septum morphogenesis|lung morphogenesis|prostatic bud formation|ureteric bud formation|fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation|negative regulation of cartilage development|somite development|BMP signaling pathway involved in heart development|heart trabecula morphogenesis|pharyngeal arch artery morphogenesis|negative regulation of canonical Wnt signaling pathway|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of glomerulus development|negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation|negative regulation of apoptotic signaling pathway hsa04350 TGF-beta signaling pathway NOL10 530.8519258 562.8639105 498.8399412 0.886253199 -0.174209165 0.521093483 1 5.137508535 4.476942852 79954 nucleolar protein 10 "GO:0000462,GO:0003723,GO:0005730,GO:0032040" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleolus|small-subunit processome" NOL11 1399.910633 1324.446873 1475.374392 1.113955133 0.155691126 0.516795275 1 24.85347938 27.22237889 25926 nucleolar protein 11 "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0030490,GO:0034455,GO:1901838" RNA binding|protein binding|nucleoplasm|nucleolus|rRNA processing|maturation of SSU-rRNA|t-UTP complex|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I NOL12 279.8234878 280.9117483 278.7352272 0.99225194 -0.011221617 0.984787755 1 5.297435941 5.168432503 79159 nucleolar protein 12 "GO:0003723,GO:0005515,GO:0005730,GO:0019843,GO:0042802" RNA binding|protein binding|nucleolus|rRNA binding|identical protein binding NOL3 296.0738203 303.8008537 288.3467868 0.94913093 -0.075320978 0.82112036 1 7.87053068 7.345161023 8996 nucleolar protein 3 "GO:0001666,GO:0001974,GO:0002931,GO:0003723,GO:0005123,GO:0005509,GO:0005515,GO:0005730,GO:0005739,GO:0005829,GO:0006376,GO:0008380,GO:0010659,GO:0010667,GO:0010804,GO:0014736,GO:0014808,GO:0014876,GO:0016020,GO:0016529,GO:0035877,GO:0042802,GO:0043027,GO:0043066,GO:0051259,GO:0060547,GO:0089720,GO:0090201,GO:0097193,GO:1901222,GO:1902109,GO:1902176,GO:1903298,GO:1990001,GO:2001237" response to hypoxia|blood vessel remodeling|response to ischemia|RNA binding|death receptor binding|calcium ion binding|protein binding|nucleolus|mitochondrion|cytosol|mRNA splice site selection|RNA splicing|cardiac muscle cell apoptotic process|negative regulation of cardiac muscle cell apoptotic process|negative regulation of tumor necrosis factor-mediated signaling pathway|negative regulation of muscle atrophy|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to injury involved in regulation of muscle adaptation|membrane|sarcoplasmic reticulum|death effector domain binding|identical protein binding|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|protein complex oligomerization|negative regulation of necrotic cell death|caspase binding|negative regulation of release of cytochrome c from mitochondria|intrinsic apoptotic signaling pathway|regulation of NIK/NF-kappaB signaling|negative regulation of mitochondrial membrane permeability involved in apoptotic process|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway|inhibition of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of extrinsic apoptotic signaling pathway NOL4 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.022587001 8715 nucleolar protein 4 "GO:0003723,GO:0005730" RNA binding|nucleolus NOL4L 1875.510568 1950.77603 1800.245106 0.922835363 -0.115854806 0.625907345 1 10.98083866 9.963935728 140688 nucleolar protein 4 like "GO:0005515,GO:0005654,GO:0005829" protein binding|nucleoplasm|cytosol NOL6 1077.289938 1206.880104 947.6997726 0.785247656 -0.348780364 0.15320574 1 11.93642939 9.216207848 65083 nucleolar protein 6 "GO:0000794,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0006364,GO:0006409,GO:0032040,GO:0032545,GO:0034456" condensed nuclear chromosome|RNA binding|protein binding|nucleoplasm|nucleolus|mitochondrion|rRNA processing|tRNA export from nucleus|small-subunit processome|CURI complex|UTP-C complex hsa03008 Ribosome biogenesis in eukaryotes NOL7 1026.573198 947.8170471 1105.329349 1.166184289 0.221795792 0.366549904 1 28.72416456 32.9371313 51406 nucleolar protein 7 "GO:0003723,GO:0005515,GO:0005694,GO:0005730,GO:0005739" RNA binding|protein binding|chromosome|nucleolus|mitochondrion NOL8 712.1374208 792.7953786 631.4794631 0.796522634 -0.328212737 0.199064077 1 8.250786322 6.46196557 55035 nucleolar protein 8 "GO:0003723,GO:0005515,GO:0005694,GO:0005730,GO:0006364,GO:1902570" RNA binding|protein binding|chromosome|nucleolus|rRNA processing|protein localization to nucleolus NOL9 510.6726812 550.3789439 470.9664184 0.855713002 -0.224801083 0.410270841 1 3.757062252 3.1611689 79707 nucleolar protein 9 "GO:0000448,GO:0000460,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0006396,GO:0016020,GO:0016310,GO:0045111,GO:0051731" "cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of 5.8S rRNA|RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|rRNA processing|RNA processing|membrane|phosphorylation|intermediate filament cytoskeleton|polynucleotide 5'-hydroxyl-kinase activity" NOLC1 6108.347741 6755.40734 5461.288142 0.8084321 -0.306801488 0.205764261 1 96.26800369 76.52382925 9221 nucleolar and coiled-body phosphoprotein 1 "GO:0000278,GO:0001650,GO:0003677,GO:0003700,GO:0003723,GO:0005515,GO:0005524,GO:0005525,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0006417,GO:0006970,GO:0007000,GO:0008134,GO:0008139,GO:0008284,GO:0014029,GO:0014032,GO:0015030,GO:0019904,GO:0030674,GO:0031428,GO:0031429,GO:0033979,GO:0034512,GO:0034513,GO:0042306,GO:0045893,GO:0046982,GO:0062064,GO:0062065" "mitotic cell cycle|fibrillar center|DNA binding|DNA-binding transcription factor activity|RNA binding|protein binding|ATP binding|GTP binding|nucleoplasm|nucleolus|cytoplasm|rRNA processing|regulation of translation|response to osmotic stress|nucleolus organization|transcription factor binding|nuclear localization sequence binding|positive regulation of cell population proliferation|neural crest formation|neural crest cell development|Cajal body|protein domain specific binding|protein-macromolecule adaptor activity|box C/D RNP complex|box H/ACA snoRNP complex|box H/ACA RNA metabolic process|box C/D RNA binding|box H/ACA snoRNA binding|regulation of protein import into nucleus|positive regulation of transcription, DNA-templated|protein heterodimerization activity|box C/D snoRNP complex binding|box H/ACA snoRNP complex binding" NOM1 964.1326596 961.3424276 966.9228917 1.005804866 0.008350438 0.977722303 1 8.431401559 8.338437633 64434 nucleolar protein with MIF4G domain 1 "GO:0003723,GO:0005515,GO:0005730,GO:0008150,GO:0042274,GO:0048820" RNA binding|protein binding|nucleolus|biological_process|ribosomal small subunit biogenesis|hair follicle maturation NOMO1 1831.763495 1887.310783 1776.216207 0.941136045 -0.087524809 0.713414754 1 23.3586057 21.61575958 23420 NODAL modulator 1 "GO:0003674,GO:0005515,GO:0005575,GO:0005789,GO:0008150,GO:0016020,GO:0016021,GO:0030246,GO:1900108" molecular_function|protein binding|cellular_component|endoplasmic reticulum membrane|biological_process|membrane|integral component of membrane|carbohydrate binding|negative regulation of nodal signaling pathway NOMO2 726.0792126 780.310412 671.8480132 0.861000959 -0.21591325 0.398049237 1 9.366561524 7.929667989 283820 NODAL modulator 2 "GO:0005515,GO:0005789,GO:0016021,GO:0030246,GO:0032991" protein binding|endoplasmic reticulum membrane|integral component of membrane|carbohydrate binding|protein-containing complex NOMO3 47.24006644 41.61655531 52.86357758 1.270253561 0.345116509 0.591397975 1 0.556780915 0.69541802 408050 NODAL modulator 3 "GO:0003674,GO:0005515,GO:0005575,GO:0005789,GO:0008150,GO:0016021,GO:0030246,GO:1900108" molecular_function|protein binding|cellular_component|endoplasmic reticulum membrane|biological_process|integral component of membrane|carbohydrate binding|negative regulation of nodal signaling pathway NONO 13923.67582 13989.40507 13857.94657 0.990602996 -0.01362111 0.958525818 1 269.0410223 262.0531113 4841 non-POU domain containing octamer binding "GO:0000398,GO:0000976,GO:0001650,GO:0002218,GO:0003676,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006310,GO:0006355,GO:0006397,GO:0007623,GO:0008380,GO:0016020,GO:0016363,GO:0016607,GO:0042382,GO:0042752,GO:0042802,GO:0045087,GO:0045892,GO:0090575,GO:1903377" "mRNA splicing, via spliceosome|transcription regulatory region sequence-specific DNA binding|fibrillar center|activation of innate immune response|nucleic acid binding|chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|DNA repair|DNA recombination|regulation of transcription, DNA-templated|mRNA processing|circadian rhythm|RNA splicing|membrane|nuclear matrix|nuclear speck|paraspeckles|regulation of circadian rhythm|identical protein binding|innate immune response|negative regulation of transcription, DNA-templated|RNA polymerase II transcription regulator complex|negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway" NOP10 1910.55436 1747.895323 2073.213397 1.186119884 0.246249834 0.298559346 1 183.9880885 214.5801144 55505 NOP10 ribonucleoprotein "GO:0000454,GO:0001522,GO:0003723,GO:0005515,GO:0005654,GO:0005697,GO:0005732,GO:0007004,GO:0016604,GO:0031118,GO:0031120,GO:0031429,GO:0034513,GO:0070034,GO:0072589,GO:0090661,GO:1904874" snoRNA guided rRNA pseudouridine synthesis|pseudouridine synthesis|RNA binding|protein binding|nucleoplasm|telomerase holoenzyme complex|sno(s)RNA-containing ribonucleoprotein complex|telomere maintenance via telomerase|nuclear body|rRNA pseudouridine synthesis|snRNA pseudouridine synthesis|box H/ACA snoRNP complex|box H/ACA snoRNA binding|telomerase RNA binding|box H/ACA scaRNP complex|box H/ACA telomerase RNP complex|positive regulation of telomerase RNA localization to Cajal body hsa03008 Ribosome biogenesis in eukaryotes NOP14 1184.185841 1288.032387 1080.339295 0.838751654 -0.253684389 0.295498366 1 19.33068649 15.94233187 8602 NOP14 nucleolar protein "GO:0000447,GO:0000462,GO:0000472,GO:0000480,GO:0003723,GO:0005654,GO:0005730,GO:0006364,GO:0016020,GO:0019899,GO:0030490,GO:0030515,GO:0030686,GO:0030692,GO:0032040,GO:0042274" "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleoplasm|nucleolus|rRNA processing|membrane|enzyme binding|maturation of SSU-rRNA|snoRNA binding|90S preribosome|Noc4p-Nop14p complex|small-subunit processome|ribosomal small subunit biogenesis" NOP16 355.8485431 346.4578229 365.2392633 1.05420989 0.076162131 0.807160846 1 18.88643233 19.57709244 51491 NOP16 nucleolar protein "GO:0003723,GO:0005654,GO:0005730,GO:0042273,GO:0043231" RNA binding|nucleoplasm|nucleolus|ribosomal large subunit biogenesis|intracellular membrane-bounded organelle NOP2 1140.423676 1262.02204 1018.825313 0.807295975 -0.308830396 0.203947639 1 22.91656916 18.19087401 4839 NOP2 nucleolar protein "GO:0000027,GO:0000470,GO:0001510,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006357,GO:0008284,GO:0009383,GO:0070475,GO:1901796" ribosomal large subunit assembly|maturation of LSU-rRNA|RNA methylation|RNA binding|protein binding|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|positive regulation of cell population proliferation|rRNA (cytosine-C5-)-methyltransferase activity|rRNA base methylation|regulation of signal transduction by p53 class mediator NOP53 4033.82244 4147.089736 3920.555144 0.945375045 -0.081041313 0.734331393 1 147.1559556 136.789624 29997 NOP53 ribosome biogenesis factor "GO:0000027,GO:0000122,GO:0001650,GO:0001932,GO:0002039,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006281,GO:0006364,GO:0006974,GO:0007095,GO:0008097,GO:0014067,GO:0016032,GO:0031333,GO:0032435,GO:0032436,GO:0033553,GO:0039535,GO:0042802,GO:0042981,GO:0043231,GO:0050821,GO:0051726,GO:0051898,GO:0071456,GO:1901796,GO:1901797,GO:1901837,GO:1902570,GO:1903006,GO:1903715,GO:1990173" ribosomal large subunit assembly|negative regulation of transcription by RNA polymerase II|fibrillar center|regulation of protein phosphorylation|p53 binding|RNA binding|protein binding|nucleoplasm|nucleolus|cytosol|DNA repair|rRNA processing|cellular response to DNA damage stimulus|mitotic G2 DNA damage checkpoint|5S rRNA binding|negative regulation of phosphatidylinositol 3-kinase signaling|viral process|negative regulation of protein-containing complex assembly|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|rDNA heterochromatin|regulation of RIG-I signaling pathway|identical protein binding|regulation of apoptotic process|intracellular membrane-bounded organelle|protein stabilization|regulation of cell cycle|negative regulation of protein kinase B signaling|cellular response to hypoxia|regulation of signal transduction by p53 class mediator|negative regulation of signal transduction by p53 class mediator|negative regulation of transcription of nucleolar large rRNA by RNA polymerase I|protein localization to nucleolus|positive regulation of protein K63-linked deubiquitination|regulation of aerobic respiration|protein localization to nucleoplasm NOP56 2548.507936 2775.824239 2321.191634 0.836217078 -0.258050587 0.275070726 1 77.43891159 63.67214075 10528 NOP56 ribonucleoprotein "GO:0001650,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005732,GO:0005737,GO:0006364,GO:0016020,GO:0030515,GO:0031428,GO:0032040,GO:0045296,GO:0070761,GO:1990226" fibrillar center|RNA binding|protein binding|nucleoplasm|nucleolus|sno(s)RNA-containing ribonucleoprotein complex|cytoplasm|rRNA processing|membrane|snoRNA binding|box C/D RNP complex|small-subunit processome|cadherin binding|pre-snoRNP complex|histone methyltransferase binding "hsa03008,hsa05017" Ribosome biogenesis in eukaryotes|Spinocerebellar ataxia NOP58 1173.841452 1218.324657 1129.358248 0.926976436 -0.109395429 0.654032194 1 32.60769696 29.72076606 51602 NOP58 ribonucleoprotein "GO:0001094,GO:0001650,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005732,GO:0005829,GO:0006364,GO:0015030,GO:0016020,GO:0030515,GO:0031428,GO:0032040,GO:0048254,GO:0051117,GO:0070761" TFIID-class transcription factor complex binding|fibrillar center|RNA binding|protein binding|nucleoplasm|nucleolus|sno(s)RNA-containing ribonucleoprotein complex|cytosol|rRNA processing|Cajal body|membrane|snoRNA binding|box C/D RNP complex|small-subunit processome|snoRNA localization|ATPase binding|pre-snoRNP complex hsa03008 Ribosome biogenesis in eukaryotes NOP9 1329.611655 1459.700677 1199.522633 0.821759318 -0.283212185 0.238606543 1 14.91795142 12.0538284 161424 NOP9 nucleolar protein "GO:0000056,GO:0000447,GO:0000472,GO:0000480,GO:0003723,GO:0005575,GO:0005730,GO:0008150,GO:0030686,GO:0030688" "ribosomal small subunit export from nucleus|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|cellular_component|nucleolus|biological_process|90S preribosome|preribosome, small subunit precursor" NOPCHAP1 227.7776416 239.295193 216.2600901 0.903737711 -0.14602397 0.681747031 1 0.54288151 0.482412591 121053 NOP protein chaperone 1 NOS1AP 84.83397478 69.70773014 99.96021942 1.433990452 0.520035418 0.297726207 1 0.500225015 0.705314552 9722 nitric oxide synthase 1 adaptor protein "GO:0003062,GO:0005515,GO:0005634,GO:0005739,GO:0005829,GO:0005901,GO:0010628,GO:0010750,GO:0030018,GO:0030315,GO:0031965,GO:0033017,GO:0042383,GO:0045428,GO:0045429,GO:0048471,GO:0050998,GO:0050999,GO:0051000,GO:0060307,GO:0098901,GO:0098974,GO:0098978,GO:1901381,GO:1901841,GO:1902261,GO:1902514,GO:1902937,GO:1903762,GO:1990454,GO:2000170" regulation of heart rate by chemical signal|protein binding|nucleus|mitochondrion|cytosol|caveola|positive regulation of gene expression|positive regulation of nitric oxide mediated signal transduction|Z disc|T-tubule|nuclear membrane|sarcoplasmic reticulum membrane|sarcolemma|regulation of nitric oxide biosynthetic process|positive regulation of nitric oxide biosynthetic process|perinuclear region of cytoplasm|nitric-oxide synthase binding|regulation of nitric-oxide synthase activity|positive regulation of nitric-oxide synthase activity|regulation of ventricular cardiac muscle cell membrane repolarization|regulation of cardiac muscle cell action potential|postsynaptic actin cytoskeleton organization|glutamatergic synapse|positive regulation of potassium ion transmembrane transport|regulation of high voltage-gated calcium channel activity|positive regulation of delayed rectifier potassium channel activity|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|inward rectifier potassium channel complex|positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|L-type voltage-gated calcium channel complex|positive regulation of peptidyl-cysteine S-nitrosylation hsa04713 Circadian entrainment NOS3 4.845408743 1.040413883 8.650403604 8.314386946 3.055609892 0.118982446 1 0.010769002 0.088039362 4846 nitric oxide synthase 3 "GO:0000139,GO:0001974,GO:0003100,GO:0003180,GO:0003184,GO:0003203,GO:0003785,GO:0004517,GO:0005515,GO:0005516,GO:0005634,GO:0005737,GO:0005794,GO:0005829,GO:0005856,GO:0005886,GO:0005901,GO:0006527,GO:0006809,GO:0007005,GO:0007263,GO:0008217,GO:0008285,GO:0009408,GO:0009725,GO:0010181,GO:0010544,GO:0010628,GO:0012506,GO:0014740,GO:0014806,GO:0016491,GO:0016709,GO:0019430,GO:0020037,GO:0030666,GO:0031284,GO:0031644,GO:0032496,GO:0034405,GO:0034617,GO:0034618,GO:0042311,GO:0043536,GO:0043542,GO:0045454,GO:0045747,GO:0045766,GO:0045776,GO:0046870,GO:0048873,GO:0050660,GO:0050661,GO:0050999,GO:0055114,GO:0070168,GO:0097746,GO:1902042" "Golgi membrane|blood vessel remodeling|regulation of systemic arterial blood pressure by endothelin|aortic valve morphogenesis|pulmonary valve morphogenesis|endocardial cushion morphogenesis|actin monomer binding|nitric-oxide synthase activity|protein binding|calmodulin binding|nucleus|cytoplasm|Golgi apparatus|cytosol|cytoskeleton|plasma membrane|caveola|arginine catabolic process|nitric oxide biosynthetic process|mitochondrion organization|nitric oxide mediated signal transduction|regulation of blood pressure|negative regulation of cell population proliferation|response to heat|response to hormone|FMN binding|negative regulation of platelet activation|positive regulation of gene expression|vesicle membrane|negative regulation of muscle hyperplasia|smooth muscle hyperplasia|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|removal of superoxide radicals|heme binding|endocytic vesicle membrane|positive regulation of guanylate cyclase activity|regulation of nervous system process|response to lipopolysaccharide|response to fluid shear stress|tetrahydrobiopterin binding|arginine binding|vasodilation|positive regulation of blood vessel endothelial cell migration|endothelial cell migration|cell redox homeostasis|positive regulation of Notch signaling pathway|positive regulation of angiogenesis|negative regulation of blood pressure|cadmium ion binding|homeostasis of number of cells within a tissue|flavin adenine dinucleotide binding|NADP binding|regulation of nitric-oxide synthase activity|oxidation-reduction process|negative regulation of biomineral tissue development|blood vessel diameter maintenance|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors" "hsa00220,hsa00330,hsa04020,hsa04022,hsa04066,hsa04071,hsa04151,hsa04370,hsa04371,hsa04611,hsa04915,hsa04921,hsa04926,hsa04931,hsa04933,hsa05418" Arginine biosynthesis|Arginine and proline metabolism|Calcium signaling pathway|cGMP-PKG signaling pathway|HIF-1 signaling pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|VEGF signaling pathway|Apelin signaling pathway|Platelet activation|Estrogen signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|Fluid shear stress and atherosclerosis NOSIP 1346.269567 1266.183695 1426.355439 1.12649961 0.171846814 0.475121538 1 38.90264632 43.0904837 51070 nitric oxide synthase interacting protein "GO:0000139,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007275,GO:0016567,GO:0043086,GO:0050999,GO:0051001,GO:0061630" Golgi membrane|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|multicellular organism development|protein ubiquitination|negative regulation of catalytic activity|regulation of nitric-oxide synthase activity|negative regulation of nitric-oxide synthase activity|ubiquitin protein ligase activity NOTCH1 886.0211318 1005.039811 767.0024529 0.76315629 -0.389949553 0.116821731 1 5.63237714 4.226456405 4851 notch receptor 1 "GO:0000122,GO:0000139,GO:0001669,GO:0001701,GO:0001708,GO:0001837,GO:0001889,GO:0001947,GO:0002040,GO:0002052,GO:0002193,GO:0002437,GO:0003151,GO:0003157,GO:0003160,GO:0003162,GO:0003169,GO:0003180,GO:0003181,GO:0003182,GO:0003184,GO:0003192,GO:0003198,GO:0003203,GO:0003207,GO:0003208,GO:0003209,GO:0003213,GO:0003214,GO:0003219,GO:0003222,GO:0003241,GO:0003252,GO:0003256,GO:0003270,GO:0003273,GO:0003332,GO:0003344,GO:0003713,GO:0004857,GO:0004888,GO:0005112,GO:0005509,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005789,GO:0005829,GO:0005886,GO:0005912,GO:0006355,GO:0006367,GO:0006955,GO:0006959,GO:0007050,GO:0007219,GO:0007221,GO:0007283,GO:0007368,GO:0007386,GO:0007411,GO:0007440,GO:0007492,GO:0007507,GO:0008284,GO:0008285,GO:0009912,GO:0009986,GO:0010614,GO:0010628,GO:0010629,GO:0010812,GO:0010832,GO:0014031,GO:0014807,GO:0016021,GO:0016324,GO:0019899,GO:0021515,GO:0021915,GO:0030216,GO:0030279,GO:0030324,GO:0030335,GO:0030513,GO:0030514,GO:0030900,GO:0031069,GO:0031100,GO:0031490,GO:0031960,GO:0032495,GO:0032496,GO:0035116,GO:0035148,GO:0035914,GO:0035924,GO:0042246,GO:0042802,GO:0043086,GO:0043235,GO:0045070,GO:0045603,GO:0045608,GO:0045618,GO:0045662,GO:0045668,GO:0045747,GO:0045892,GO:0045893,GO:0045944,GO:0045955,GO:0045967,GO:0046427,GO:0046533,GO:0046579,GO:0048103,GO:0048708,GO:0048709,GO:0048711,GO:0048715,GO:0048754,GO:0048873,GO:0050679,GO:0050768,GO:0055008,GO:0060038,GO:0060045,GO:0060253,GO:0060271,GO:0060317,GO:0060354,GO:0060411,GO:0060412,GO:0060528,GO:0060740,GO:0060768,GO:0060842,GO:0060843,GO:0060948,GO:0060956,GO:0060979,GO:0060982,GO:0061314,GO:0061384,GO:0061419,GO:0062043,GO:0070168,GO:0070374,GO:0070986,GO:0071372,GO:0072017,GO:0072044,GO:0072144,GO:0090051,GO:0090090,GO:0097150,GO:0120163,GO:1901201,GO:1902263,GO:1902339,GO:1903849,GO:2000048,GO:2000737,GO:2000811,GO:2000974,GO:2001027" "negative regulation of transcription by RNA polymerase II|Golgi membrane|acrosomal vesicle|in utero embryonic development|cell fate specification|epithelial to mesenchymal transition|liver development|heart looping|sprouting angiogenesis|positive regulation of neuroblast proliferation|MAML1-RBP-Jkappa- ICN1 complex|inflammatory response to antigenic stimulus|outflow tract morphogenesis|endocardium development|endocardium morphogenesis|atrioventricular node development|coronary vein morphogenesis|aortic valve morphogenesis|atrioventricular valve morphogenesis|coronary sinus valve morphogenesis|pulmonary valve morphogenesis|mitral valve formation|epithelial to mesenchymal transition involved in endocardial cushion formation|endocardial cushion morphogenesis|cardiac chamber formation|cardiac ventricle morphogenesis|cardiac atrium morphogenesis|cardiac right atrium morphogenesis|cardiac left ventricle morphogenesis|cardiac right ventricle formation|ventricular trabecula myocardium morphogenesis|growth involved in heart morphogenesis|negative regulation of cell proliferation involved in heart valve morphogenesis|regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation|cell migration involved in endocardial cushion formation|negative regulation of extracellular matrix constituent secretion|pericardium morphogenesis|transcription coactivator activity|enzyme inhibitor activity|transmembrane signaling receptor activity|Notch binding|calcium ion binding|protein binding|extracellular region|nucleus|nucleoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|adherens junction|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|immune response|humoral immune response|cell cycle arrest|Notch signaling pathway|positive regulation of transcription of Notch receptor target|spermatogenesis|determination of left/right symmetry|compartment pattern specification|axon guidance|foregut morphogenesis|endoderm development|heart development|positive regulation of cell population proliferation|negative regulation of cell population proliferation|auditory receptor cell fate commitment|cell surface|negative regulation of cardiac muscle hypertrophy|positive regulation of gene expression|negative regulation of gene expression|negative regulation of cell-substrate adhesion|negative regulation of myotube differentiation|mesenchymal cell development|regulation of somitogenesis|integral component of membrane|apical plasma membrane|enzyme binding|cell differentiation in spinal cord|neural tube development|keratinocyte differentiation|negative regulation of ossification|lung development|positive regulation of cell migration|positive regulation of BMP signaling pathway|negative regulation of BMP signaling pathway|forebrain development|hair follicle morphogenesis|animal organ regeneration|chromatin DNA binding|response to corticosteroid|response to muramyl dipeptide|response to lipopolysaccharide|embryonic hindlimb morphogenesis|tube formation|skeletal muscle cell differentiation|cellular response to vascular endothelial growth factor stimulus|tissue regeneration|identical protein binding|negative regulation of catalytic activity|receptor complex|positive regulation of viral genome replication|positive regulation of endothelial cell differentiation|negative regulation of inner ear auditory receptor cell differentiation|positive regulation of keratinocyte differentiation|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of calcium ion-dependent exocytosis|negative regulation of growth rate|positive regulation of receptor signaling pathway via JAK-STAT|negative regulation of photoreceptor cell differentiation|positive regulation of Ras protein signal transduction|somatic stem cell division|astrocyte differentiation|oligodendrocyte differentiation|positive regulation of astrocyte differentiation|negative regulation of oligodendrocyte differentiation|branching morphogenesis of an epithelial tube|homeostasis of number of cells within a tissue|positive regulation of epithelial cell proliferation|negative regulation of neurogenesis|cardiac muscle tissue morphogenesis|cardiac muscle cell proliferation|positive regulation of cardiac muscle cell proliferation|negative regulation of glial cell proliferation|cilium assembly|cardiac epithelial to mesenchymal transition|negative regulation of cell adhesion molecule production|cardiac septum morphogenesis|ventricular septum morphogenesis|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development|prostate gland epithelium morphogenesis|regulation of epithelial cell proliferation involved in prostate gland development|arterial endothelial cell differentiation|venous endothelial cell differentiation|cardiac vascular smooth muscle cell development|endocardial cell differentiation|vasculogenesis involved in coronary vascular morphogenesis|coronary artery morphogenesis|Notch signaling involved in heart development|heart trabecula morphogenesis|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|positive regulation of cardiac epithelial to mesenchymal transition|negative regulation of biomineral tissue development|positive regulation of ERK1 and ERK2 cascade|left/right axis specification|cellular response to follicle-stimulating hormone stimulus|distal tubule development|collecting duct development|glomerular mesangial cell development|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of canonical Wnt signaling pathway|neuronal stem cell population maintenance|negative regulation of cold-induced thermogenesis|regulation of extracellular matrix assembly|apoptotic process involved in embryonic digit morphogenesis|positive regulation of apoptotic process involved in morphogenesis|positive regulation of aorta morphogenesis|negative regulation of cell-cell adhesion mediated by cadherin|negative regulation of stem cell differentiation|negative regulation of anoikis|negative regulation of pro-B cell differentiation|negative regulation of endothelial cell chemotaxis" "hsa01522,hsa04330,hsa04658,hsa04919,hsa05020,hsa05165,hsa05200,hsa05206,hsa05224" Endocrine resistance|Notch signaling pathway|Th1 and Th2 cell differentiation|Thyroid hormone signaling pathway|Prion disease|Human papillomavirus infection|Pathways in cancer|MicroRNAs in cancer|Breast cancer other NOTCH2 10129.3802 11336.34967 8922.410739 0.787062062 -0.345450695 0.169999308 1 51.3408135 39.73222656 4853 notch receptor 2 "GO:0000122,GO:0000139,GO:0001701,GO:0001709,GO:0001947,GO:0002011,GO:0002315,GO:0002437,GO:0003184,GO:0005509,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005789,GO:0005886,GO:0005887,GO:0005929,GO:0006367,GO:0006915,GO:0006959,GO:0007050,GO:0007219,GO:0007275,GO:0007399,GO:0007411,GO:0009887,GO:0009986,GO:0010629,GO:0010838,GO:0016020,GO:0019827,GO:0019899,GO:0030097,GO:0030326,GO:0030513,GO:0035264,GO:0035622,GO:0038023,GO:0042060,GO:0042742,GO:0043011,GO:0043065,GO:0043066,GO:0043235,GO:0045672,GO:0045967,GO:0046579,GO:0046849,GO:0051059,GO:0060413,GO:0060674,GO:0061073,GO:0061314,GO:0070374,GO:0070986,GO:0072014,GO:0072015,GO:0072104,GO:0072574,GO:1990705,GO:2000249,GO:2001204" negative regulation of transcription by RNA polymerase II|Golgi membrane|in utero embryonic development|cell fate determination|heart looping|morphogenesis of an epithelial sheet|marginal zone B cell differentiation|inflammatory response to antigenic stimulus|pulmonary valve morphogenesis|calcium ion binding|protein binding|extracellular region|nucleus|nucleoplasm|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|cilium|transcription initiation from RNA polymerase II promoter|apoptotic process|humoral immune response|cell cycle arrest|Notch signaling pathway|multicellular organism development|nervous system development|axon guidance|animal organ morphogenesis|cell surface|negative regulation of gene expression|positive regulation of keratinocyte proliferation|membrane|stem cell population maintenance|enzyme binding|hemopoiesis|embryonic limb morphogenesis|positive regulation of BMP signaling pathway|multicellular organism growth|intrahepatic bile duct development|signaling receptor activity|wound healing|defense response to bacterium|myeloid dendritic cell differentiation|positive regulation of apoptotic process|negative regulation of apoptotic process|receptor complex|positive regulation of osteoclast differentiation|negative regulation of growth rate|positive regulation of Ras protein signal transduction|bone remodeling|NF-kappaB binding|atrial septum morphogenesis|placenta blood vessel development|ciliary body morphogenesis|Notch signaling involved in heart development|positive regulation of ERK1 and ERK2 cascade|left/right axis specification|proximal tubule development|glomerular visceral epithelial cell development|glomerular capillary formation|hepatocyte proliferation|cholangiocyte proliferation|regulation of actin cytoskeleton reorganization|regulation of osteoclast development "hsa01522,hsa04330,hsa04658,hsa04919,hsa05165,hsa05200,hsa05206,hsa05224" Endocrine resistance|Notch signaling pathway|Th1 and Th2 cell differentiation|Thyroid hormone signaling pathway|Human papillomavirus infection|Pathways in cancer|MicroRNAs in cancer|Breast cancer NOTCH2NLA 314.3062153 277.7905067 350.8219239 1.262901055 0.336741612 0.278851435 1 2.784592183 3.45781779 388677 notch 2 N-terminal like A "GO:0005112,GO:0005509,GO:0005515,GO:0005576,GO:0005737,GO:0007219,GO:0021987,GO:0030154,GO:0045747" Notch binding|calcium ion binding|protein binding|extracellular region|cytoplasm|Notch signaling pathway|cerebral cortex development|cell differentiation|positive regulation of Notch signaling pathway NOTCH2NLB 278.3767234 293.3967149 263.3567319 0.89761309 -0.155834379 0.636520037 1 1.432181783 1.26403326 100996763 notch 2 N-terminal like B "GO:0005112,GO:0005509,GO:0005515,GO:0005576,GO:0007219,GO:0021987,GO:0045747" Notch binding|calcium ion binding|protein binding|extracellular region|Notch signaling pathway|cerebral cortex development|positive regulation of Notch signaling pathway NOTCH2NLC 237.8200893 263.2247123 212.4154663 0.806973876 -0.309406125 0.366477752 1 1.607853853 1.275784216 100996717 notch 2 N-terminal like C "GO:0005509,GO:0005515,GO:0005576,GO:0007219,GO:0021987,GO:0045747" calcium ion binding|protein binding|extracellular region|Notch signaling pathway|cerebral cortex development|positive regulation of Notch signaling pathway NOTCH4 12.8516881 9.363724944 16.33965125 1.744994791 0.80322273 0.460499144 1 0.074088182 0.127120108 4855 notch receptor 4 "GO:0000122,GO:0000139,GO:0001569,GO:0001709,GO:0001763,GO:0001837,GO:0001886,GO:0001944,GO:0005112,GO:0005509,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005789,GO:0005829,GO:0005886,GO:0005887,GO:0006367,GO:0007221,GO:0009986,GO:0030097,GO:0030154,GO:0030879,GO:0035278,GO:0038023,GO:0042060,GO:0045596,GO:0045602,GO:0045747,GO:0045893,GO:0060354,GO:2000048" "negative regulation of transcription by RNA polymerase II|Golgi membrane|branching involved in blood vessel morphogenesis|cell fate determination|morphogenesis of a branching structure|epithelial to mesenchymal transition|endothelial cell morphogenesis|vasculature development|Notch binding|calcium ion binding|protein binding|extracellular region|nucleus|nucleoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|integral component of plasma membrane|transcription initiation from RNA polymerase II promoter|positive regulation of transcription of Notch receptor target|cell surface|hemopoiesis|cell differentiation|mammary gland development|miRNA mediated inhibition of translation|signaling receptor activity|wound healing|negative regulation of cell differentiation|negative regulation of endothelial cell differentiation|positive regulation of Notch signaling pathway|positive regulation of transcription, DNA-templated|negative regulation of cell adhesion molecule production|negative regulation of cell-cell adhesion mediated by cadherin" "hsa01522,hsa04330,hsa04919,hsa05165,hsa05200,hsa05206,hsa05224" Endocrine resistance|Notch signaling pathway|Thyroid hormone signaling pathway|Human papillomavirus infection|Pathways in cancer|MicroRNAs in cancer|Breast cancer NOTUM 5.444873611 4.161655531 6.728091692 1.616686351 0.693039812 0.747994079 1 0.09990999 0.158820246 147111 "notum, palmitoleoyl-protein carboxylesterase" "GO:0004629,GO:0005515,GO:0005576,GO:0005788,GO:0016055,GO:0030178,GO:0043687,GO:0044267,GO:0090090,GO:1990697,GO:1990699" phospholipase C activity|protein binding|extracellular region|endoplasmic reticulum lumen|Wnt signaling pathway|negative regulation of Wnt signaling pathway|post-translational protein modification|cellular protein metabolic process|negative regulation of canonical Wnt signaling pathway|protein depalmitoleylation|palmitoleyl hydrolase activity hsa04310 Wnt signaling pathway NOVA2 2.923096831 1.040413883 4.80577978 4.619103859 2.207612985 0.416510993 1 0.006625102 0.030089949 4858 NOVA alternative splicing regulator 2 "GO:0000381,GO:0000398,GO:0003723,GO:0003729,GO:0005634,GO:0005737,GO:0010468,GO:0051252,GO:0120163" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|cytoplasm|regulation of gene expression|regulation of RNA metabolic process|negative regulation of cold-induced thermogenesis" NOX4 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.026976345 50507 NADPH oxidase 4 "GO:0000166,GO:0000902,GO:0001666,GO:0001725,GO:0003015,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005739,GO:0005789,GO:0005886,GO:0005925,GO:0006801,GO:0006952,GO:0006954,GO:0007569,GO:0008285,GO:0009055,GO:0010467,GO:0014911,GO:0016021,GO:0016174,GO:0016175,GO:0016324,GO:0019826,GO:0020037,GO:0022900,GO:0034599,GO:0042554,GO:0043020,GO:0043065,GO:0048471,GO:0050660,GO:0050667,GO:0051496,GO:0055114,GO:0061098,GO:0071320,GO:0071480,GO:0071560,GO:0072341,GO:0072593,GO:0097038,GO:1903409,GO:1990782,GO:2000379" nucleotide binding|cell morphogenesis|response to hypoxia|stress fiber|heart process|protein binding|nucleus|nucleoplasm|nucleolus|mitochondrion|endoplasmic reticulum membrane|plasma membrane|focal adhesion|superoxide metabolic process|defense response|inflammatory response|cell aging|negative regulation of cell population proliferation|electron transfer activity|gene expression|positive regulation of smooth muscle cell migration|integral component of membrane|NAD(P)H oxidase H2O2-forming activity|superoxide-generating NAD(P)H oxidase activity|apical plasma membrane|oxygen sensor activity|heme binding|electron transport chain|cellular response to oxidative stress|superoxide anion generation|NADPH oxidase complex|positive regulation of apoptotic process|perinuclear region of cytoplasm|flavin adenine dinucleotide binding|homocysteine metabolic process|positive regulation of stress fiber assembly|oxidation-reduction process|positive regulation of protein tyrosine kinase activity|cellular response to cAMP|cellular response to gamma radiation|cellular response to transforming growth factor beta stimulus|modified amino acid binding|reactive oxygen species metabolic process|perinuclear endoplasmic reticulum|reactive oxygen species biosynthetic process|protein tyrosine kinase binding|positive regulation of reactive oxygen species metabolic process "hsa04933,hsa05010,hsa05022" AGE-RAGE signaling pathway in diabetic complications|Alzheimer disease|Pathways of neurodegeneration - multiple diseases NOX5 7.406814487 5.202069413 9.61155956 1.847641543 0.88568489 0.555147706 1 0.032289472 0.058661052 79400 NADPH oxidase 5 "GO:0000293,GO:0001525,GO:0001816,GO:0001935,GO:0005509,GO:0005789,GO:0005886,GO:0006915,GO:0015252,GO:0016021,GO:0016175,GO:0020037,GO:0033215,GO:0034599,GO:0042554,GO:0043012,GO:0050660,GO:0050661,GO:0055114,GO:0061640,GO:1902600" ferric-chelate reductase activity|angiogenesis|cytokine production|endothelial cell proliferation|calcium ion binding|endoplasmic reticulum membrane|plasma membrane|apoptotic process|proton channel activity|integral component of membrane|superoxide-generating NAD(P)H oxidase activity|heme binding|reductive iron assimilation|cellular response to oxidative stress|superoxide anion generation|regulation of fusion of sperm to egg plasma membrane|flavin adenine dinucleotide binding|NADP binding|oxidation-reduction process|cytoskeleton-dependent cytokinesis|proton transmembrane transport NOXA1 72.76983553 93.63724944 51.90242162 0.554292463 -0.851280704 0.103829943 1 2.116581069 1.153572938 10811 NADPH oxidase activator 1 "GO:0005515,GO:0005829,GO:0006801,GO:0010310,GO:0016176,GO:0017124,GO:0019899,GO:0031267,GO:0042554,GO:0043020,GO:0050790,GO:0060263" protein binding|cytosol|superoxide metabolic process|regulation of hydrogen peroxide metabolic process|superoxide-generating NADPH oxidase activator activity|SH3 domain binding|enzyme binding|small GTPase binding|superoxide anion generation|NADPH oxidase complex|regulation of catalytic activity|regulation of respiratory burst NOXRED1 11.89053214 9.363724944 14.41733934 1.539701286 0.622650484 0.600615154 1 0.162564994 0.246113073 122945 NADP dependent oxidoreductase domain containing 1 "GO:0003674,GO:0004735,GO:0005575,GO:0008150,GO:0055114,GO:0055129" molecular_function|pyrroline-5-carboxylate reductase activity|cellular_component|biological_process|oxidation-reduction process|L-proline biosynthetic process NPAS1 22.10155657 12.48496659 31.71814655 2.540507122 1.345116509 0.104867567 1 0.266626539 0.666031808 4861 neuronal PAS domain protein 1 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001964,GO:0003700,GO:0005634,GO:0006357,GO:0007417,GO:0042711,GO:0045892,GO:0046982" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|startle response|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|central nervous system development|maternal behavior|negative regulation of transcription, DNA-templated|protein heterodimerization activity" NPAS2 2089.098583 2221.283639 1956.913526 0.880983181 -0.182813618 0.43993239 1 13.66837603 11.84010937 4862 neuronal PAS domain protein 2 "GO:0000785,GO:0000978,GO:0000981,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006357,GO:0006974,GO:0007417,GO:0007623,GO:0019216,GO:0032922,GO:0042493,GO:0045739,GO:0045893,GO:0045944,GO:0046872,GO:0046983,GO:0051775,GO:0051879,GO:0060548,GO:1990513,GO:1990837,GO:2000987,GO:2001020" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|central nervous system development|circadian rhythm|regulation of lipid metabolic process|circadian regulation of gene expression|response to drug|positive regulation of DNA repair|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|protein dimerization activity|response to redox state|Hsp90 protein binding|negative regulation of cell death|CLOCK-BMAL transcription complex|sequence-specific double-stranded DNA binding|positive regulation of behavioral fear response|regulation of response to DNA damage stimulus" hsa04710 Circadian rhythm NPAT 1111.525446 1121.566165 1101.484726 0.98209518 -0.026065244 0.918595958 1 6.459737201 6.237917238 4863 "nuclear protein, coactivator of histone transcription" "GO:0000083,GO:0001701,GO:0003712,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008022,GO:0010468,GO:0015030,GO:0045892,GO:0045893,GO:0045944,GO:0097504" "regulation of transcription involved in G1/S transition of mitotic cell cycle|in utero embryonic development|transcription coregulator activity|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|protein C-terminus binding|regulation of gene expression|Cajal body|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|Gemini of coiled bodies" other NPBWR1 5.202069413 10.40413883 0 0 #NAME? 0.017147124 0.770503287 0.131919641 0 2831 neuropeptides B and W receptor 1 "GO:0004930,GO:0004985,GO:0005515,GO:0005886,GO:0005887,GO:0007186,GO:0007218,GO:0007268,GO:0008188,GO:0016021,GO:0019222,GO:0038003,GO:0042277,GO:0042923,GO:0043005,GO:0045202" G protein-coupled receptor activity|opioid receptor activity|protein binding|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|chemical synaptic transmission|neuropeptide receptor activity|integral component of membrane|regulation of metabolic process|opioid receptor signaling pathway|peptide binding|neuropeptide binding|neuron projection|synapse hsa04080 Neuroactive ligand-receptor interaction NPC1 4480.737381 4600.710189 4360.764572 0.947845961 -0.077275475 0.7470503 1 32.83383887 30.60064672 4864 NPC intracellular cholesterol transporter 1 "GO:0001618,GO:0004888,GO:0005515,GO:0005576,GO:0005635,GO:0005764,GO:0005765,GO:0005783,GO:0005794,GO:0005887,GO:0006486,GO:0006897,GO:0006914,GO:0007041,GO:0007628,GO:0008203,GO:0008206,GO:0015248,GO:0015485,GO:0016020,GO:0016021,GO:0016242,GO:0030301,GO:0031579,GO:0031902,GO:0032367,GO:0033344,GO:0034383,GO:0038023,GO:0042493,GO:0042632,GO:0045121,GO:0046686,GO:0046718,GO:0048471,GO:0060548,GO:0070062,GO:0071383,GO:0071404,GO:0090150,GO:1905103" virus receptor activity|transmembrane signaling receptor activity|protein binding|extracellular region|nuclear envelope|lysosome|lysosomal membrane|endoplasmic reticulum|Golgi apparatus|integral component of plasma membrane|protein glycosylation|endocytosis|autophagy|lysosomal transport|adult walking behavior|cholesterol metabolic process|bile acid metabolic process|sterol transporter activity|cholesterol binding|membrane|integral component of membrane|negative regulation of macroautophagy|cholesterol transport|membrane raft organization|late endosome membrane|intracellular cholesterol transport|cholesterol efflux|low-density lipoprotein particle clearance|signaling receptor activity|response to drug|cholesterol homeostasis|membrane raft|response to cadmium ion|viral entry into host cell|perinuclear region of cytoplasm|negative regulation of cell death|extracellular exosome|cellular response to steroid hormone stimulus|cellular response to low-density lipoprotein particle stimulus|establishment of protein localization to membrane|integral component of lysosomal membrane "hsa04142,hsa04979" Lysosome|Cholesterol metabolism NPC2 3222.594064 2985.987843 3459.200286 1.158477686 0.212230255 0.370644833 1 128.6171777 146.506815 10577 NPC intracellular cholesterol transporter 2 "GO:0005515,GO:0005576,GO:0005615,GO:0005764,GO:0005783,GO:0008203,GO:0009615,GO:0015485,GO:0015914,GO:0015918,GO:0019747,GO:0019899,GO:0030301,GO:0032366,GO:0032367,GO:0032934,GO:0033344,GO:0034383,GO:0035578,GO:0042632,GO:0043202,GO:0043312,GO:0046836,GO:0070062,GO:0120009,GO:0120020" protein binding|extracellular region|extracellular space|lysosome|endoplasmic reticulum|cholesterol metabolic process|response to virus|cholesterol binding|phospholipid transport|sterol transport|regulation of isoprenoid metabolic process|enzyme binding|cholesterol transport|intracellular sterol transport|intracellular cholesterol transport|sterol binding|cholesterol efflux|low-density lipoprotein particle clearance|azurophil granule lumen|cholesterol homeostasis|lysosomal lumen|neutrophil degranulation|glycolipid transport|extracellular exosome|intermembrane lipid transfer|cholesterol transfer activity "hsa04142,hsa04979" Lysosome|Cholesterol metabolism NPDC1 853.4820666 756.3808927 950.5832405 1.256752054 0.329700047 0.186929977 1 27.36722581 33.8182833 56654 "neural proliferation, differentiation and control 1" "GO:0005515,GO:0005886,GO:0016021,GO:0050776" protein binding|plasma membrane|integral component of membrane|regulation of immune response NPEPL1 873.4229231 863.5435226 883.3023236 1.022881071 0.032638415 0.900414841 1 19.78777616 19.90184362 79716 aminopeptidase like 1 "GO:0005634,GO:0005737,GO:0006508,GO:0030145,GO:0070006" nucleus|cytoplasm|proteolysis|manganese ion binding|metalloaminopeptidase activity NPEPPS 3187.33262 3132.686201 3241.97904 1.034887899 0.0494745 0.835726847 1 36.05471315 36.68821073 9520 aminopeptidase puromycin sensitive "GO:0000209,GO:0004177,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0008270,GO:0042277,GO:0043171,GO:0070006,GO:0070062,GO:0071456,GO:1903955" protein polyubiquitination|aminopeptidase activity|nucleus|cytoplasm|cytosol|proteolysis|zinc ion binding|peptide binding|peptide catabolic process|metalloaminopeptidase activity|extracellular exosome|cellular response to hypoxia|positive regulation of protein targeting to mitochondrion NPFF 4.082397604 6.242483296 1.922311912 0.307940257 -1.699277611 0.406294648 1 0.497238597 0.150557529 8620 neuropeptide FF-amide peptide precursor "GO:0001664,GO:0002438,GO:0003254,GO:0005102,GO:0005184,GO:0005576,GO:0005615,GO:0007186,GO:0007204,GO:0007218,GO:0007268,GO:0010459,GO:0021510,GO:0030103,GO:0030425,GO:0031982,GO:0032099,GO:0042493,GO:0043204,GO:0043278,GO:0043679,GO:0045777,GO:0046676,GO:0051930,GO:0060079,GO:0060135,GO:0070253,GO:0098794" G protein-coupled receptor binding|acute inflammatory response to antigenic stimulus|regulation of membrane depolarization|signaling receptor binding|neuropeptide hormone activity|extracellular region|extracellular space|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|chemical synaptic transmission|negative regulation of heart rate|spinal cord development|vasopressin secretion|dendrite|vesicle|negative regulation of appetite|response to drug|perikaryon|response to morphine|axon terminus|positive regulation of blood pressure|negative regulation of insulin secretion|regulation of sensory perception of pain|excitatory postsynaptic potential|maternal process involved in female pregnancy|somatostatin secretion|postsynapse hsa04080 Neuroactive ligand-receptor interaction NPFFR1 3.923881751 2.080827765 5.766935736 2.771462315 1.470647391 0.503574097 1 0.012006698 0.032719281 64106 neuropeptide FF receptor 1 "GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0005929,GO:0007186,GO:0007218,GO:0008150,GO:0008188,GO:0042277" G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|cilium|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|biological_process|neuropeptide receptor activity|peptide binding hsa04080 Neuroactive ligand-receptor interaction NPHP1 115.3676685 126.9304937 103.8048432 0.817808552 -0.290164945 0.522524934 1 2.230506144 1.793602705 4867 nephrocystin 1 "GO:0005198,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005911,GO:0005912,GO:0005923,GO:0005929,GO:0007165,GO:0007588,GO:0007632,GO:0016020,GO:0030030,GO:0030036,GO:0031514,GO:0032391,GO:0048515,GO:0060041,GO:0090251,GO:0097711,GO:0098609,GO:1903348" structural molecule activity|protein binding|cytoplasm|cytosol|cytoskeleton|cell-cell junction|adherens junction|bicellular tight junction|cilium|signal transduction|excretion|visual behavior|membrane|cell projection organization|actin cytoskeleton organization|motile cilium|photoreceptor connecting cilium|spermatid differentiation|retina development in camera-type eye|protein localization involved in establishment of planar polarity|ciliary basal body-plasma membrane docking|cell-cell adhesion|positive regulation of bicellular tight junction assembly NPHP3 661.2860883 668.9861265 653.5860501 0.976979976 -0.033599101 0.902512409 1 6.675871359 6.413052581 27031 nephrocystin 3 "GO:0001822,GO:0001947,GO:0003283,GO:0005515,GO:0005576,GO:0005829,GO:0005929,GO:0007368,GO:0016055,GO:0030324,GO:0035469,GO:0045494,GO:0048496,GO:0060027,GO:0060271,GO:0060287,GO:0060993,GO:0071908,GO:0071909,GO:0071910,GO:0072189,GO:0090090,GO:2000095,GO:2000167" "kidney development|heart looping|atrial septum development|protein binding|extracellular region|cytosol|cilium|determination of left/right symmetry|Wnt signaling pathway|lung development|determination of pancreatic left/right asymmetry|photoreceptor cell maintenance|maintenance of animal organ identity|convergent extension involved in gastrulation|cilium assembly|epithelial cilium movement involved in determination of left/right asymmetry|kidney morphogenesis|determination of intestine left/right asymmetry|determination of stomach left/right asymmetry|determination of liver left/right asymmetry|ureter development|negative regulation of canonical Wnt signaling pathway|regulation of Wnt signaling pathway, planar cell polarity pathway|regulation of planar cell polarity pathway involved in neural tube closure" NPHP4 398.2828298 388.0743782 408.4912813 1.052610799 0.073972101 0.805981698 1 2.652852096 2.745693385 261734 nephrocystin 4 "GO:0005198,GO:0005515,GO:0005654,GO:0005813,GO:0005829,GO:0005911,GO:0005923,GO:0007165,GO:0007632,GO:0016604,GO:0030036,GO:0030317,GO:0035329,GO:0035845,GO:0035869,GO:0036064,GO:0043231,GO:0045494,GO:0060041,GO:0090090,GO:0097470,GO:0097546,GO:0097711,GO:0097730,GO:0098609,GO:0120206,GO:1903348,GO:1904491" structural molecule activity|protein binding|nucleoplasm|centrosome|cytosol|cell-cell junction|bicellular tight junction|signal transduction|visual behavior|nuclear body|actin cytoskeleton organization|flagellated sperm motility|hippo signaling|photoreceptor cell outer segment organization|ciliary transition zone|ciliary basal body|intracellular membrane-bounded organelle|photoreceptor cell maintenance|retina development in camera-type eye|negative regulation of canonical Wnt signaling pathway|ribbon synapse|ciliary base|ciliary basal body-plasma membrane docking|non-motile cilium|cell-cell adhesion|photoreceptor distal connecting cilium|positive regulation of bicellular tight junction assembly|protein localization to ciliary transition zone NPIPA1 101.5202259 104.0413883 98.99906347 0.951535395 -0.071670773 0.898909552 1 5.122230324 4.792423942 9284 nuclear pore complex interacting protein family member A1 "GO:0005643,GO:0005654,GO:0015031,GO:0031965,GO:0051028" nuclear pore|nucleoplasm|protein transport|nuclear membrane|mRNA transport NPIPA2 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.031984434 0.02905344 642799 nuclear pore complex interacting protein family member A2 GO:0005654 nucleoplasm NPIPA3 4.444088692 3.121241648 5.766935736 1.847641543 0.88568489 0.705170935 1 0.031013765 0.056343443 642778 nuclear pore complex interacting protein family member A3 GO:0005654 nucleoplasm NPIPA5 28.70070054 34.33365813 23.06774294 0.671869652 -0.573746729 0.451384139 1 0.88818431 0.586758379 100288332 nuclear pore complex interacting protein family member A5 GO:0005654 nucleoplasm NPIPA7 22.09652615 24.96993318 19.22311912 0.769850643 -0.377349516 0.680227645 1 0.602986172 0.456441379 101059938 nuclear pore complex interacting protein family member A7 "GO:0005515,GO:0005654" protein binding|nucleoplasm NPIPA8 59.68540407 65.54607461 53.82473354 0.821174019 -0.284240111 0.630228271 1 1.563035538 1.262046136 101059953 nuclear pore complex interacting protein family member A8 GO:0005654 nucleoplasm NPIPB11 25.460572 24.96993318 25.95121081 1.039298368 0.055609892 1 1 0.236990831 0.242182617 728888 nuclear pore complex interacting protein family member B11 "GO:0005654,GO:0016021" nucleoplasm|integral component of membrane NPIPB12 18.09338647 20.80827765 15.3784953 0.739056617 -0.436243205 0.660847429 1 0.362789786 0.26363553 440353 nuclear pore complex interacting protein family member B12 "GO:0005654,GO:0016021" nucleoplasm|integral component of membrane NPIPB13 11.04826308 12.48496659 9.61155956 0.769850643 -0.377349516 0.799003187 1 0.170671035 0.129192552 613037 "nuclear pore complex interacting protein family, member B13" "GO:0005654,GO:0016021" nucleoplasm|integral component of membrane NPIPB2 27.62065769 31.21241648 24.0288989 0.769850643 -0.377349516 0.642993258 1 0.434128043 0.328621139 729978 nuclear pore complex interacting protein family member B2 GO:0005654 nucleoplasm NPIPB3 91.86903734 103.0009744 80.7371003 0.783847928 -0.351354307 0.473689275 1 1.498629415 1.155040588 23117 nuclear pore complex interacting protein family member B3 "GO:0003674,GO:0005515,GO:0005654,GO:0008150,GO:0016021" molecular_function|protein binding|nucleoplasm|biological_process|integral component of membrane NPIPB4 36.74660885 43.69738307 29.79583464 0.681867712 -0.552436222 0.421641627 1 0.407914819 0.273489583 440345 nuclear pore complex interacting protein family member B4 "GO:0005654,GO:0016021" nucleoplasm|integral component of membrane NPIPB5 426.9193636 382.8723088 470.9664184 1.230087441 0.298760873 0.294263511 1 4.756329477 5.752797592 100132247 nuclear pore complex interacting protein family member B5 "GO:0005654,GO:0016021" nucleoplasm|integral component of membrane NPIPB6 4.404459729 2.080827765 6.728091692 3.233372701 1.693039812 0.389066599 1 0.018783822 0.059718776 728741 nuclear pore complex interacting protein family member B6 GO:0005654 nucleoplasm NPIPB9 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.03628293 0.03295803 100507607 nuclear pore complex interacting protein family member B9 GO:0005654 nucleoplasm NPL 17.85561269 14.56579436 21.14543103 1.451718356 0.537761587 0.578658858 1 0.273522053 0.390432439 80896 N-acetylneuraminate pyruvate lyase "GO:0005515,GO:0005829,GO:0005975,GO:0008747,GO:0019262,GO:0042802" protein binding|cytosol|carbohydrate metabolic process|N-acetylneuraminate lyase activity|N-acetylneuraminate catabolic process|identical protein binding hsa00520 Amino sugar and nucleotide sugar metabolism NPLOC4 4055.849769 4145.008908 3966.69063 0.956980001 -0.063439319 0.790775821 1 45.23752704 42.56698559 55666 "NPL4 homolog, ubiquitin recognition factor" "GO:0005515,GO:0005634,GO:0005654,GO:0005783,GO:0005829,GO:0006511,GO:0007030,GO:0030433,GO:0030970,GO:0031625,GO:0032480,GO:0034098,GO:0036501,GO:0039536,GO:0042175,GO:0043130,GO:0046872,GO:0070987" "protein binding|nucleus|nucleoplasm|endoplasmic reticulum|cytosol|ubiquitin-dependent protein catabolic process|Golgi organization|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|ubiquitin protein ligase binding|negative regulation of type I interferon production|VCP-NPL4-UFD1 AAA ATPase complex|UFD1-NPL4 complex|negative regulation of RIG-I signaling pathway|nuclear outer membrane-endoplasmic reticulum membrane network|ubiquitin binding|metal ion binding|error-free translesion synthesis" hsa04141 Protein processing in endoplasmic reticulum NPM1 17203.58565 16461.42845 17945.74285 1.090169235 0.124552112 0.641327584 1 405.219641 434.3657642 4869 nucleophosmin 1 "GO:0000055,GO:0000056,GO:0001046,GO:0003682,GO:0003713,GO:0003723,GO:0004860,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0005925,GO:0006281,GO:0006334,GO:0006338,GO:0006357,GO:0006407,GO:0006886,GO:0006913,GO:0007098,GO:0007165,GO:0007569,GO:0008104,GO:0008134,GO:0008284,GO:0008285,GO:0010824,GO:0010826,GO:0016020,GO:0016032,GO:0019901,GO:0030957,GO:0031616,GO:0032071,GO:0032991,GO:0032993,GO:0033613,GO:0034080,GO:0034644,GO:0042255,GO:0042273,GO:0042274,GO:0042393,GO:0042803,GO:0043023,GO:0043024,GO:0043066,GO:0044387,GO:0045727,GO:0045893,GO:0045944,GO:0046599,GO:0051059,GO:0051082,GO:0051092,GO:0060699,GO:0060735,GO:1902629,GO:1902751,GO:1990904" "ribosomal large subunit export from nucleus|ribosomal small subunit export from nucleus|core promoter sequence-specific DNA binding|chromatin binding|transcription coactivator activity|RNA binding|protein kinase inhibitor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|cytosol|focal adhesion|DNA repair|nucleosome assembly|chromatin remodeling|regulation of transcription by RNA polymerase II|rRNA export from nucleus|intracellular protein transport|nucleocytoplasmic transport|centrosome cycle|signal transduction|cell aging|protein localization|transcription factor binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|regulation of centrosome duplication|negative regulation of centrosome duplication|membrane|viral process|protein kinase binding|Tat protein binding|spindle pole centrosome|regulation of endodeoxyribonuclease activity|protein-containing complex|protein-DNA complex|activating transcription factor binding|CENP-A containing nucleosome assembly|cellular response to UV|ribosome assembly|ribosomal large subunit biogenesis|ribosomal small subunit biogenesis|histone binding|protein homodimerization activity|ribosomal large subunit binding|ribosomal small subunit binding|negative regulation of apoptotic process|negative regulation of protein kinase activity by regulation of protein phosphorylation|positive regulation of translation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of centriole replication|NF-kappaB binding|unfolded protein binding|positive regulation of NF-kappaB transcription factor activity|regulation of endoribonuclease activity|regulation of eIF2 alpha phosphorylation by dsRNA|regulation of mRNA stability involved in cellular response to UV|positive regulation of cell cycle G2/M phase transition|ribonucleoprotein complex" NPM2 7.644588267 11.44455271 3.844623824 0.335934826 -1.573746729 0.246344754 1 0.240936783 0.079584651 10361 nucleophosmin/nucleoplasmin 2 "GO:0000785,GO:0001824,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006338,GO:0007096,GO:0007338,GO:0009994,GO:0019899,GO:0042393,GO:0042802,GO:0043085,GO:0045740,GO:0045836,GO:0051054" chromatin|blastocyst development|chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|chromatin remodeling|regulation of exit from mitosis|single fertilization|oocyte differentiation|enzyme binding|histone binding|identical protein binding|positive regulation of catalytic activity|positive regulation of DNA replication|positive regulation of meiotic nuclear division|positive regulation of DNA metabolic process NPM3 1353.041089 1456.579436 1249.502743 0.857833574 -0.221230314 0.357071774 1 88.63736306 74.76374466 10360 nucleophosmin/nucleoplasmin 3 "GO:0003682,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006338,GO:0006364,GO:0009303,GO:0015629,GO:0042393" chromatin binding|RNA binding|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|chromatin remodeling|rRNA processing|rRNA transcription|actin cytoskeleton|histone binding NPNT 62.84627468 72.82897178 52.86357758 0.725859178 -0.462238413 0.40919901 1 0.822940582 0.587343316 255743 nephronectin "GO:0001657,GO:0001658,GO:0005178,GO:0005201,GO:0005509,GO:0005576,GO:0007160,GO:0010811,GO:0016020,GO:0030154,GO:0030198,GO:0033631,GO:0045669,GO:0062023,GO:0070062,GO:0070374,GO:0071356" ureteric bud development|branching involved in ureteric bud morphogenesis|integrin binding|extracellular matrix structural constituent|calcium ion binding|extracellular region|cell-matrix adhesion|positive regulation of cell-substrate adhesion|membrane|cell differentiation|extracellular matrix organization|cell-cell adhesion mediated by integrin|positive regulation of osteoblast differentiation|collagen-containing extracellular matrix|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|cellular response to tumor necrosis factor hsa04512 ECM-receptor interaction NPR1 29.42408271 28.09117483 30.75699059 1.094898692 0.130797388 0.905437675 1 0.351259225 0.378157618 4881 natriuretic peptide receptor 1 "GO:0001653,GO:0004383,GO:0004672,GO:0005524,GO:0005525,GO:0005886,GO:0006182,GO:0006468,GO:0007165,GO:0007166,GO:0007168,GO:0007186,GO:0007589,GO:0008217,GO:0008528,GO:0010753,GO:0016021,GO:0016525,GO:0016941,GO:0017046,GO:0019901,GO:0019934,GO:0030308,GO:0035810,GO:0035815,GO:0042417,GO:0042562,GO:0043114,GO:0043235,GO:0048662,GO:0097746,GO:1903779" peptide receptor activity|guanylate cyclase activity|protein kinase activity|ATP binding|GTP binding|plasma membrane|cGMP biosynthetic process|protein phosphorylation|signal transduction|cell surface receptor signaling pathway|receptor guanylyl cyclase signaling pathway|G protein-coupled receptor signaling pathway|body fluid secretion|regulation of blood pressure|G protein-coupled peptide receptor activity|positive regulation of cGMP-mediated signaling|integral component of membrane|negative regulation of angiogenesis|natriuretic peptide receptor activity|peptide hormone binding|protein kinase binding|cGMP-mediated signaling|negative regulation of cell growth|positive regulation of urine volume|positive regulation of renal sodium excretion|dopamine metabolic process|hormone binding|regulation of vascular permeability|receptor complex|negative regulation of smooth muscle cell proliferation|blood vessel diameter maintenance|regulation of cardiac conduction "hsa00230,hsa04022,hsa04024,hsa04270,hsa04714,hsa04921,hsa04923,hsa04924,hsa04925" Purine metabolism|cGMP-PKG signaling pathway|cAMP signaling pathway|Vascular smooth muscle contraction|Thermogenesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Aldosterone synthesis and secretion NPR2 68.0483441 83.23311061 52.86357758 0.635126781 -0.654883491 0.223183155 1 0.753008669 0.470253006 4882 natriuretic peptide receptor 2 "GO:0001503,GO:0001653,GO:0004383,GO:0004672,GO:0005515,GO:0005524,GO:0005525,GO:0005886,GO:0005887,GO:0006182,GO:0006468,GO:0007165,GO:0007168,GO:0008217,GO:0010753,GO:0016941,GO:0017046,GO:0019934,GO:0022414,GO:0042562,GO:0042802,GO:0051447,GO:0060348,GO:0097011,GO:1900194,GO:1903779" ossification|peptide receptor activity|guanylate cyclase activity|protein kinase activity|protein binding|ATP binding|GTP binding|plasma membrane|integral component of plasma membrane|cGMP biosynthetic process|protein phosphorylation|signal transduction|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|positive regulation of cGMP-mediated signaling|natriuretic peptide receptor activity|peptide hormone binding|cGMP-mediated signaling|reproductive process|hormone binding|identical protein binding|negative regulation of meiotic cell cycle|bone development|cellular response to granulocyte macrophage colony-stimulating factor stimulus|negative regulation of oocyte maturation|regulation of cardiac conduction "hsa00230,hsa04022,hsa04270,hsa04921" Purine metabolism|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Oxytocin signaling pathway NPR3 10.92937619 9.363724944 12.49502743 1.334407781 0.416199607 0.772652545 1 0.145311076 0.190659506 4883 natriuretic peptide receptor 3 "GO:0001501,GO:0002158,GO:0005515,GO:0005887,GO:0007193,GO:0007194,GO:0007200,GO:0008217,GO:0008528,GO:0016941,GO:0017046,GO:0030157,GO:0031404,GO:0032991,GO:0033688,GO:0035810,GO:0042277,GO:0042562,GO:0042803,GO:0048015,GO:0048662,GO:0051000,GO:0070062,GO:0120163" skeletal system development|osteoclast proliferation|protein binding|integral component of plasma membrane|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|phospholipase C-activating G protein-coupled receptor signaling pathway|regulation of blood pressure|G protein-coupled peptide receptor activity|natriuretic peptide receptor activity|peptide hormone binding|pancreatic juice secretion|chloride ion binding|protein-containing complex|regulation of osteoblast proliferation|positive regulation of urine volume|peptide binding|hormone binding|protein homodimerization activity|phosphatidylinositol-mediated signaling|negative regulation of smooth muscle cell proliferation|positive regulation of nitric-oxide synthase activity|extracellular exosome|negative regulation of cold-induced thermogenesis NPRL2 415.1722561 415.1251392 415.219373 1.000227001 0.000327456 1 1 12.28074596 12.0779854 10641 "NPR2 like, GATOR1 complex subunit" "GO:0004672,GO:0005096,GO:0005515,GO:0005765,GO:0006468,GO:0006995,GO:0010508,GO:0032007,GO:0033673,GO:0034198,GO:0043547,GO:1990130,GO:2000785" protein kinase activity|GTPase activator activity|protein binding|lysosomal membrane|protein phosphorylation|cellular response to nitrogen starvation|positive regulation of autophagy|negative regulation of TOR signaling|negative regulation of kinase activity|cellular response to amino acid starvation|positive regulation of GTPase activity|GATOR1 complex|regulation of autophagosome assembly hsa04150 mTOR signaling pathway NPRL3 530.8223577 536.8535634 524.791152 0.977531282 -0.032785224 0.910398891 1 8.020965282 7.709540232 8131 "NPR3 like, GATOR1 complex subunit" "GO:0003281,GO:0005096,GO:0005515,GO:0005765,GO:0032007,GO:0034198,GO:0035909,GO:0038202,GO:0043547,GO:0048738,GO:0060021,GO:1990130,GO:2000785" ventricular septum development|GTPase activator activity|protein binding|lysosomal membrane|negative regulation of TOR signaling|cellular response to amino acid starvation|aorta morphogenesis|TORC1 signaling|positive regulation of GTPase activity|cardiac muscle tissue development|roof of mouth development|GATOR1 complex|regulation of autophagosome assembly hsa04150 mTOR signaling pathway NPTN 1725.788505 1906.038233 1545.538777 0.81086452 -0.302467207 0.202556957 1 36.77576187 29.32116051 27020 neuroplastin "GO:0001772,GO:0001818,GO:0001934,GO:0005105,GO:0005515,GO:0005886,GO:0006874,GO:0007156,GO:0007204,GO:0007411,GO:0008542,GO:0009986,GO:0010976,GO:0030424,GO:0030425,GO:0042734,GO:0044325,GO:0045743,GO:0048170,GO:0050839,GO:0060077,GO:0060291,GO:0070374,GO:0070593,GO:0098632,GO:0098685,GO:0098978,GO:0098982,GO:0099059,GO:0099061,GO:0099557,GO:1900273,GO:1902683,GO:1903829,GO:1904861" "immunological synapse|negative regulation of cytokine production|positive regulation of protein phosphorylation|type 1 fibroblast growth factor receptor binding|protein binding|plasma membrane|cellular calcium ion homeostasis|homophilic cell adhesion via plasma membrane adhesion molecules|positive regulation of cytosolic calcium ion concentration|axon guidance|visual learning|cell surface|positive regulation of neuron projection development|axon|dendrite|presynaptic membrane|ion channel binding|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of long-term neuronal synaptic plasticity|cell adhesion molecule binding|inhibitory synapse|long-term synaptic potentiation|positive regulation of ERK1 and ERK2 cascade|dendrite self-avoidance|cell-cell adhesion mediator activity|Schaffer collateral - CA1 synapse|glutamatergic synapse|GABA-ergic synapse|integral component of presynaptic active zone membrane|integral component of postsynaptic density membrane|trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission|positive regulation of long-term synaptic potentiation|regulation of receptor localization to synapse|positive regulation of cellular protein localization|excitatory synapse assembly" NPTXR 10.60731406 13.52538047 7.689247648 0.56850509 -0.814754828 0.49718369 1 0.123812126 0.069209979 23467 neuronal pentraxin receptor "GO:0016021,GO:0046872,GO:0098962,GO:0098978" integral component of membrane|metal ion binding|regulation of postsynaptic neurotransmitter receptor activity|glutamatergic synapse NPY1R 79.02741008 68.66731625 89.38750391 1.301747451 0.380449582 0.462954158 1 0.975418808 1.248501419 4886 neuropeptide Y receptor Y1 "GO:0001601,GO:0001602,GO:0003151,GO:0004983,GO:0005515,GO:0005886,GO:0005887,GO:0006006,GO:0007186,GO:0007187,GO:0007193,GO:0007218,GO:0007626,GO:0007631,GO:0008217,GO:0019233,GO:0040014" "peptide YY receptor activity|pancreatic polypeptide receptor activity|outflow tract morphogenesis|neuropeptide Y receptor activity|protein binding|plasma membrane|integral component of plasma membrane|glucose metabolic process|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|locomotory behavior|feeding behavior|regulation of blood pressure|sensory perception of pain|regulation of multicellular organism growth" "hsa04024,hsa04080,hsa04923" cAMP signaling pathway|Neuroactive ligand-receptor interaction|Regulation of lipolysis in adipocytes NPY5R 2.561405743 4.161655531 0.961155956 0.230955193 -2.11431511 0.482263142 1 0.020698966 0.004700538 4889 neuropeptide Y receptor Y5 "GO:0001601,GO:0001602,GO:0002675,GO:0002865,GO:0003151,GO:0003214,GO:0004983,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007218,GO:0007268,GO:0007568,GO:0014050,GO:0016020,GO:0032229,GO:0042755,GO:0043005,GO:0043066,GO:0045202,GO:0048661,GO:0060112,GO:0070374" "peptide YY receptor activity|pancreatic polypeptide receptor activity|positive regulation of acute inflammatory response|negative regulation of acute inflammatory response to antigenic stimulus|outflow tract morphogenesis|cardiac left ventricle morphogenesis|neuropeptide Y receptor activity|cytoplasm|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|chemical synaptic transmission|aging|negative regulation of glutamate secretion|membrane|negative regulation of synaptic transmission, GABAergic|eating behavior|neuron projection|negative regulation of apoptotic process|synapse|positive regulation of smooth muscle cell proliferation|generation of ovulation cycle rhythm|positive regulation of ERK1 and ERK2 cascade" hsa04080 Neuroactive ligand-receptor interaction NQO1 6777.553247 7051.925297 6503.181198 0.922185208 -0.11687157 0.632022875 1 149.2853202 135.3650146 1728 NAD(P)H quinone dehydrogenase 1 "GO:0002931,GO:0003723,GO:0003955,GO:0004128,GO:0004784,GO:0005515,GO:0005737,GO:0005829,GO:0006116,GO:0006521,GO:0006805,GO:0006809,GO:0006979,GO:0007271,GO:0007568,GO:0007584,GO:0009636,GO:0009725,GO:0009743,GO:0014075,GO:0019430,GO:0030425,GO:0032355,GO:0033574,GO:0042493,GO:0042802,GO:0043025,GO:0043066,GO:0043086,GO:0043279,GO:0043525,GO:0045202,GO:0045454,GO:0045471,GO:0051602,GO:0070301,GO:0070995,GO:0071248,GO:1904772,GO:1904844,GO:1904880,GO:1905395" "response to ischemia|RNA binding|NAD(P)H dehydrogenase (quinone) activity|cytochrome-b5 reductase activity, acting on NAD(P)H|superoxide dismutase activity|protein binding|cytoplasm|cytosol|NADH oxidation|regulation of cellular amino acid metabolic process|xenobiotic metabolic process|nitric oxide biosynthetic process|response to oxidative stress|synaptic transmission, cholinergic|aging|response to nutrient|response to toxic substance|response to hormone|response to carbohydrate|response to amine|removal of superoxide radicals|dendrite|response to estradiol|response to testosterone|response to drug|identical protein binding|neuronal cell body|negative regulation of apoptotic process|negative regulation of catalytic activity|response to alkaloid|positive regulation of neuron apoptotic process|synapse|cell redox homeostasis|response to ethanol|response to electrical stimulus|cellular response to hydrogen peroxide|NADPH oxidation|cellular response to metal ion|response to tetrachloromethane|response to L-glutamine|response to hydrogen sulfide|response to flavonoid" "hsa00130,hsa05200,hsa05225,hsa05418" Ubiquinone and other terpenoid-quinone biosynthesis|Pathways in cancer|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis NQO2 1090.454242 1136.13196 1044.776524 0.919590823 -0.120936026 0.622166051 1 38.18216283 34.52441534 4835 N-ribosyldihydronicotinamide:quinone reductase 2 "GO:0001512,GO:0003955,GO:0005515,GO:0005654,GO:0005829,GO:0006805,GO:0007613,GO:0008270,GO:0009055,GO:0016491,GO:0016661,GO:0022900,GO:0031404,GO:0042803,GO:0043525,GO:0055114,GO:0070062,GO:0070374,GO:0071949,GO:1904408,GO:1904707,GO:1905594,GO:2000379" "dihydronicotinamide riboside quinone reductase activity|NAD(P)H dehydrogenase (quinone) activity|protein binding|nucleoplasm|cytosol|xenobiotic metabolic process|memory|zinc ion binding|electron transfer activity|oxidoreductase activity|oxidoreductase activity, acting on other nitrogenous compounds as donors|electron transport chain|chloride ion binding|protein homodimerization activity|positive regulation of neuron apoptotic process|oxidation-reduction process|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|FAD binding|melatonin binding|positive regulation of vascular associated smooth muscle cell proliferation|resveratrol binding|positive regulation of reactive oxygen species metabolic process" NR1D1 569.7787421 562.8639105 576.6935736 1.024570172 0.035018797 0.901860991 1 11.42167772 11.50648799 9572 nuclear receptor subfamily 1 group D member 1 "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001222,GO:0001227,GO:0001678,GO:0003707,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005978,GO:0006367,GO:0007623,GO:0008270,GO:0009755,GO:0010498,GO:0016604,GO:0019216,GO:0020037,GO:0030154,GO:0030425,GO:0030522,GO:0031648,GO:0032922,GO:0034144,GO:0042632,GO:0042749,GO:0042752,GO:0043124,GO:0043197,GO:0043401,GO:0044321,GO:0045598,GO:0045892,GO:0045893,GO:0045944,GO:0050728,GO:0060086,GO:0061178,GO:0061469,GO:0061889,GO:0070859,GO:0070888,GO:0071222,GO:0071347,GO:0071356,GO:0120163,GO:0150079,GO:1903979,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|transcription corepressor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|cellular glucose homeostasis|steroid hormone receptor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|glycogen biosynthetic process|transcription initiation from RNA polymerase II promoter|circadian rhythm|zinc ion binding|hormone-mediated signaling pathway|proteasomal protein catabolic process|nuclear body|regulation of lipid metabolic process|heme binding|cell differentiation|dendrite|intracellular receptor signaling pathway|protein destabilization|circadian regulation of gene expression|negative regulation of toll-like receptor 4 signaling pathway|cholesterol homeostasis|regulation of circadian sleep/wake cycle|regulation of circadian rhythm|negative regulation of I-kappaB kinase/NF-kappaB signaling|dendritic spine|steroid hormone mediated signaling pathway|response to leptin|regulation of fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of inflammatory response|circadian temperature homeostasis|regulation of insulin secretion involved in cellular response to glucose stimulus|regulation of type B pancreatic cell proliferation|negative regulation of astrocyte activation|positive regulation of bile acid biosynthetic process|E-box binding|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to tumor necrosis factor|negative regulation of cold-induced thermogenesis|negative regulation of neuroinflammatory response|negative regulation of microglial cell activation|sequence-specific double-stranded DNA binding" hsa04710 Circadian rhythm NR1D2 1729.658281 1843.6134 1615.703162 0.876378509 -0.190373989 0.422973122 1 18.34270297 15.8061548 9975 nuclear receptor subfamily 1 group D member 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006367,GO:0008270,GO:0009755,GO:0019216,GO:0030154,GO:0030522,GO:0042752,GO:0045892,GO:0045893,GO:0045944,GO:0048512,GO:0050727,GO:0050728,GO:0055088,GO:0097009,GO:1990837,GO:2001014" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|zinc ion binding|hormone-mediated signaling pathway|regulation of lipid metabolic process|cell differentiation|intracellular receptor signaling pathway|regulation of circadian rhythm|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|circadian behavior|regulation of inflammatory response|negative regulation of inflammatory response|lipid homeostasis|energy homeostasis|sequence-specific double-stranded DNA binding|regulation of skeletal muscle cell differentiation" NR1H2 818.6823073 751.1788233 886.1857914 1.179726803 0.238452804 0.342813347 1 16.59314288 19.247808 7376 nuclear receptor subfamily 1 group H member 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006367,GO:0008270,GO:0010745,GO:0010867,GO:0010875,GO:0010884,GO:0010887,GO:0030154,GO:0031667,GO:0032270,GO:0032369,GO:0032376,GO:0034191,GO:0036151,GO:0042632,GO:0045723,GO:0045861,GO:0045892,GO:0045893,GO:0045944,GO:0046965,GO:0048384,GO:0048550,GO:0051006,GO:0051117,GO:0060336,GO:0090108,GO:0090187,GO:0090340,GO:0120163,GO:1903573" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|transcription initiation from RNA polymerase II promoter|zinc ion binding|negative regulation of macrophage derived foam cell differentiation|positive regulation of triglyceride biosynthetic process|positive regulation of cholesterol efflux|positive regulation of lipid storage|negative regulation of cholesterol storage|cell differentiation|response to nutrient levels|positive regulation of cellular protein metabolic process|negative regulation of lipid transport|positive regulation of cholesterol transport|apolipoprotein A-I receptor binding|phosphatidylcholine acyl-chain remodeling|cholesterol homeostasis|positive regulation of fatty acid biosynthetic process|negative regulation of proteolysis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|retinoid X receptor binding|retinoic acid receptor signaling pathway|negative regulation of pinocytosis|positive regulation of lipoprotein lipase activity|ATPase binding|negative regulation of interferon-gamma-mediated signaling pathway|positive regulation of high-density lipoprotein particle assembly|positive regulation of pancreatic juice secretion|positive regulation of secretion of lysosomal enzymes|negative regulation of cold-induced thermogenesis|negative regulation of response to endoplasmic reticulum stress" hsa04931 Insulin resistance Ecdysone_rcpt NR1H3 111.6865909 118.6071826 104.7659992 0.883302317 -0.179020799 0.70485145 1 2.362764967 2.052112052 10062 nuclear receptor subfamily 1 group H member 3 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0003677,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006367,GO:0008270,GO:0010745,GO:0010867,GO:0010875,GO:0010887,GO:0015485,GO:0030154,GO:0030522,GO:0032270,GO:0032369,GO:0032376,GO:0032570,GO:0032810,GO:0034145,GO:0036151,GO:0042632,GO:0042752,GO:0043031,GO:0043235,GO:0043277,GO:0045723,GO:0045893,GO:0045944,GO:0048550,GO:0050728,GO:0051006,GO:0055088,GO:0055092,GO:0060336,GO:0070328,GO:0071222,GO:0090188,GO:0090341,GO:0090575,GO:0120163,GO:1903573" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|transcription initiation from RNA polymerase II promoter|zinc ion binding|negative regulation of macrophage derived foam cell differentiation|positive regulation of triglyceride biosynthetic process|positive regulation of cholesterol efflux|negative regulation of cholesterol storage|cholesterol binding|cell differentiation|intracellular receptor signaling pathway|positive regulation of cellular protein metabolic process|negative regulation of lipid transport|positive regulation of cholesterol transport|response to progesterone|sterol response element binding|positive regulation of toll-like receptor 4 signaling pathway|phosphatidylcholine acyl-chain remodeling|cholesterol homeostasis|regulation of circadian rhythm|negative regulation of macrophage activation|receptor complex|apoptotic cell clearance|positive regulation of fatty acid biosynthetic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of pinocytosis|negative regulation of inflammatory response|positive regulation of lipoprotein lipase activity|lipid homeostasis|sterol homeostasis|negative regulation of interferon-gamma-mediated signaling pathway|triglyceride homeostasis|cellular response to lipopolysaccharide|negative regulation of pancreatic juice secretion|negative regulation of secretion of lysosomal enzymes|RNA polymerase II transcription regulator complex|negative regulation of cold-induced thermogenesis|negative regulation of response to endoplasmic reticulum stress" "hsa03320,hsa04931,hsa04932,hsa05160" PPAR signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Hepatitis C Ecdysone_rcpt NR1I2 4.523346619 5.202069413 3.844623824 0.739056617 -0.436243205 0.933440272 1 0.09426991 0.068504954 8856 nuclear receptor subfamily 1 group I member 2 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0004879,GO:0005515,GO:0005654,GO:0006355,GO:0006367,GO:0006805,GO:0007165,GO:0008144,GO:0008202,GO:0008270,GO:0016604,GO:0016922,GO:0030154,GO:0030522,GO:0042738,GO:0042908,GO:0045111,GO:0045892,GO:0045893,GO:0045944,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|nuclear receptor activity|protein binding|nucleoplasm|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|xenobiotic metabolic process|signal transduction|drug binding|steroid metabolic process|zinc ion binding|nuclear body|nuclear receptor binding|cell differentiation|intracellular receptor signaling pathway|exogenous drug catabolic process|xenobiotic transport|intermediate filament cytoskeleton|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" NR2C1 774.8855447 711.6430957 838.1279936 1.177736422 0.2360167 0.35112419 1 8.326920429 9.642811993 7181 nuclear receptor subfamily 2 group C member 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0003707,GO:0004879,GO:0005515,GO:0005654,GO:0006357,GO:0006367,GO:0008270,GO:0016605,GO:0030154,GO:0030522,GO:0038023,GO:0042803,GO:0042826,GO:0043401,GO:0048386,GO:0048856,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|steroid hormone receptor activity|nuclear receptor activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|zinc ion binding|PML body|cell differentiation|intracellular receptor signaling pathway|signaling receptor activity|protein homodimerization activity|histone deacetylase binding|steroid hormone mediated signaling pathway|positive regulation of retinoic acid receptor signaling pathway|anatomical structure development|sequence-specific double-stranded DNA binding" NR2C2 1484.243293 1545.014616 1423.471971 0.921332366 -0.1182064 0.62201149 1 7.855062439 7.116019803 7182 nuclear receptor subfamily 2 group C member 2 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0004879,GO:0005515,GO:0005654,GO:0006355,GO:0006357,GO:0006367,GO:0007283,GO:0007399,GO:0008270,GO:0030154,GO:0030522,GO:0040019,GO:0043565,GO:0045944,GO:0048856,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|spermatogenesis|nervous system development|zinc ion binding|cell differentiation|intracellular receptor signaling pathway|positive regulation of embryonic development|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|anatomical structure development|sequence-specific double-stranded DNA binding" Retinoic_acid_rcpt NR2C2AP 210.3730387 198.7190516 222.0270258 1.11729109 0.160005103 0.662396183 1 8.221139964 9.031701097 126382 nuclear receptor 2C2 associated protein "GO:0005515,GO:0005654,GO:0006367" protein binding|nucleoplasm|transcription initiation from RNA polymerase II promoter NR2E3 40.67552102 33.29324424 48.0577978 1.443469956 0.52954108 0.424424027 1 0.633665925 0.899371832 10002 nuclear receptor subfamily 2 group E member 3 "GO:0000122,GO:0000978,GO:0001228,GO:0003707,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0007165,GO:0007601,GO:0007602,GO:0008270,GO:0008285,GO:0030154,GO:0030522,GO:0042462,GO:0043401,GO:0043565,GO:0045944,GO:0048856,GO:0060041" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|steroid hormone receptor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|signal transduction|visual perception|phototransduction|zinc ion binding|negative regulation of cell population proliferation|cell differentiation|intracellular receptor signaling pathway|eye photoreceptor cell development|steroid hormone mediated signaling pathway|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|anatomical structure development|retina development in camera-type eye" NR2F1 186.6020353 155.0216685 218.182402 1.407431646 0.493064857 0.187199708 1 2.07452897 2.87089953 7025 nuclear receptor subfamily 2 group F member 1 "GO:0000122,GO:0000978,GO:0001227,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006367,GO:0007165,GO:0007399,GO:0008270,GO:0010977,GO:0030154,GO:0030522,GO:0043565,GO:0044323,GO:0045944,GO:0048856,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|signal transduction|nervous system development|zinc ion binding|negative regulation of neuron projection development|cell differentiation|intracellular receptor signaling pathway|sequence-specific DNA binding|retinoic acid-responsive element binding|positive regulation of transcription by RNA polymerase II|anatomical structure development|sequence-specific double-stranded DNA binding" COUP_TF NR2F2 1712.434159 1454.498608 1970.36971 1.354672805 0.437944439 0.065227416 1 13.51391321 18.00058902 7026 nuclear receptor subfamily 2 group F member 2 "GO:0000122,GO:0000978,GO:0001764,GO:0001893,GO:0001937,GO:0001972,GO:0003084,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007519,GO:0008270,GO:0009566,GO:0009952,GO:0009956,GO:0010596,GO:0030154,GO:0030522,GO:0030900,GO:0032355,GO:0042803,GO:0043565,GO:0045736,GO:0045892,GO:0045893,GO:0045944,GO:0048514,GO:0048856,GO:0060173,GO:0060674,GO:0060707,GO:0060838" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|neuron migration|maternal placenta development|negative regulation of endothelial cell proliferation|retinoic acid binding|positive regulation of systemic arterial blood pressure|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|skeletal muscle tissue development|zinc ion binding|fertilization|anterior/posterior pattern specification|radial pattern formation|negative regulation of endothelial cell migration|cell differentiation|intracellular receptor signaling pathway|forebrain development|response to estradiol|protein homodimerization activity|sequence-specific DNA binding|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|blood vessel morphogenesis|anatomical structure development|limb development|placenta blood vessel development|trophoblast giant cell differentiation|lymphatic endothelial cell fate commitment" COUP_TF NR2F6 696.6607747 638.8141239 754.5074255 1.181106361 0.240138888 0.350008969 1 14.30647743 16.61471519 2063 nuclear receptor subfamily 2 group F member 6 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006367,GO:0008270,GO:0030154,GO:0030522,GO:0043153,GO:0043565,GO:0048666,GO:0048856,GO:0050965,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|zinc ion binding|cell differentiation|intracellular receptor signaling pathway|entrainment of circadian clock by photoperiod|sequence-specific DNA binding|neuron development|anatomical structure development|detection of temperature stimulus involved in sensory perception of pain|sequence-specific double-stranded DNA binding" NR3C1 2262.896777 2645.772504 1880.02105 0.710575474 -0.492940202 0.037192221 0.976206556 7.061766231 4.933949824 2908 nuclear receptor subfamily 3 group C member 1 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001046,GO:0001227,GO:0001228,GO:0003700,GO:0003723,GO:0004879,GO:0004883,GO:0005496,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005759,GO:0005815,GO:0005819,GO:0005829,GO:0006325,GO:0006355,GO:0006357,GO:0006367,GO:0006915,GO:0007049,GO:0007059,GO:0007165,GO:0008270,GO:0016607,GO:0019901,GO:0030518,GO:0032991,GO:0042921,GO:0043402,GO:0045892,GO:0045944,GO:0051301,GO:0051879,GO:0071383,GO:0071385,GO:0071549,GO:0071560,GO:1902895,GO:1990239,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|core promoter sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|RNA binding|nuclear receptor activity|glucocorticoid receptor activity|steroid binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrial matrix|microtubule organizing center|spindle|cytosol|chromatin organization|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|apoptotic process|cell cycle|chromosome segregation|signal transduction|zinc ion binding|nuclear speck|protein kinase binding|intracellular steroid hormone receptor signaling pathway|protein-containing complex|glucocorticoid receptor signaling pathway|glucocorticoid mediated signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cell division|Hsp90 protein binding|cellular response to steroid hormone stimulus|cellular response to glucocorticoid stimulus|cellular response to dexamethasone stimulus|cellular response to transforming growth factor beta stimulus|positive regulation of pri-miRNA transcription by RNA polymerase II|steroid hormone binding|sequence-specific double-stranded DNA binding" hsa04080 Neuroactive ligand-receptor interaction GCR NR3C2 618.5045874 693.9560597 543.0531151 0.782546831 -0.353751004 0.176051865 1 4.53251248 3.487550653 4306 nuclear receptor subfamily 3 group C member 2 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0003707,GO:0004879,GO:0005496,GO:0005515,GO:0005654,GO:0005789,GO:0005829,GO:0006357,GO:0006367,GO:0007165,GO:0008270,GO:0030518,GO:0043235,GO:1901224,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|steroid hormone receptor activity|nuclear receptor activity|steroid binding|protein binding|nucleoplasm|endoplasmic reticulum membrane|cytosol|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|signal transduction|zinc ion binding|intracellular steroid hormone receptor signaling pathway|receptor complex|positive regulation of NIK/NF-kappaB signaling|sequence-specific double-stranded DNA binding" hsa04960 Aldosterone-regulated sodium reabsorption ThyrH_rcpt NR4A1 555.9709284 541.015219 570.9266379 1.055287574 0.077636198 0.776816619 1 3.592508136 3.727689783 3164 nuclear receptor subfamily 4 group A member 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001938,GO:0002042,GO:0003677,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005739,GO:0005829,GO:0006357,GO:0006367,GO:0007165,GO:0008270,GO:0030522,GO:0031965,GO:0035259,GO:0035767,GO:0035924,GO:0044344,GO:0045444,GO:0045786,GO:0045944,GO:0046982,GO:0061469,GO:0071376,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|positive regulation of endothelial cell proliferation|cell migration involved in sprouting angiogenesis|DNA binding|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|mitochondrion|cytosol|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|signal transduction|zinc ion binding|intracellular receptor signaling pathway|nuclear membrane|glucocorticoid receptor binding|endothelial cell chemotaxis|cellular response to vascular endothelial growth factor stimulus|cellular response to fibroblast growth factor stimulus|fat cell differentiation|negative regulation of cell cycle|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|regulation of type B pancreatic cell proliferation|cellular response to corticotropin-releasing hormone stimulus|sequence-specific double-stranded DNA binding" "hsa04010,hsa04151,hsa04925,hsa04927,hsa04934" MAPK signaling pathway|PI3K-Akt signaling pathway|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome Nuc_orph_r... NR4A2 55.96469756 56.18234966 55.74704545 0.99225194 -0.011221617 1 1 0.862337861 0.841338164 4929 nuclear receptor subfamily 4 group A member 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001666,GO:0001764,GO:0001975,GO:0003677,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006351,GO:0006357,GO:0006367,GO:0007165,GO:0008013,GO:0008270,GO:0008344,GO:0009791,GO:0016607,GO:0021952,GO:0021953,GO:0021986,GO:0030522,GO:0031668,GO:0032991,GO:0034599,GO:0035259,GO:0042053,GO:0042416,GO:0042551,GO:0043085,GO:0043524,GO:0043576,GO:0045444,GO:0045944,GO:0046965,GO:0046982,GO:0051866,GO:0060070,GO:0071376,GO:0071542,GO:1904948,GO:1990837,GO:2001234" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|response to hypoxia|neuron migration|response to amphetamine|DNA binding|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|signal transduction|beta-catenin binding|zinc ion binding|adult locomotory behavior|post-embryonic development|nuclear speck|central nervous system projection neuron axonogenesis|central nervous system neuron differentiation|habenula development|intracellular receptor signaling pathway|cellular response to extracellular stimulus|protein-containing complex|cellular response to oxidative stress|glucocorticoid receptor binding|regulation of dopamine metabolic process|dopamine biosynthetic process|neuron maturation|positive regulation of catalytic activity|negative regulation of neuron apoptotic process|regulation of respiratory gaseous exchange|fat cell differentiation|positive regulation of transcription by RNA polymerase II|retinoid X receptor binding|protein heterodimerization activity|general adaptation syndrome|canonical Wnt signaling pathway|cellular response to corticotropin-releasing hormone stimulus|dopaminergic neuron differentiation|midbrain dopaminergic neuron differentiation|sequence-specific double-stranded DNA binding|negative regulation of apoptotic signaling pathway" "hsa04925,hsa04928" "Aldosterone synthesis and secretion|Parathyroid hormone synthesis, secretion and action" NR4A3 16.81519881 12.48496659 21.14543103 1.693671415 0.760154008 0.42578865 1 0.105144346 0.175100046 8013 nuclear receptor subfamily 4 group A member 3 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003707,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0007369,GO:0008270,GO:0009444,GO:0010613,GO:0010828,GO:0019901,GO:0030522,GO:0031100,GO:0032765,GO:0035259,GO:0035497,GO:0035726,GO:0038097,GO:0042803,GO:0043303,GO:0043401,GO:0044320,GO:0045333,GO:0045444,GO:0045652,GO:0045944,GO:0046321,GO:0048008,GO:0048660,GO:0048661,GO:0050679,GO:0061469,GO:0071376,GO:0071870,GO:0097009,GO:1900625,GO:1903208,GO:1904707,GO:1904754,GO:2000253" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|steroid hormone receptor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|gastrulation|zinc ion binding|pyruvate oxidation|positive regulation of cardiac muscle hypertrophy|positive regulation of glucose transmembrane transport|protein kinase binding|intracellular receptor signaling pathway|animal organ regeneration|positive regulation of mast cell cytokine production|glucocorticoid receptor binding|cAMP response element binding|common myeloid progenitor cell proliferation|positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway|protein homodimerization activity|mast cell degranulation|steroid hormone mediated signaling pathway|cellular response to leptin stimulus|cellular respiration|fat cell differentiation|regulation of megakaryocyte differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of fatty acid oxidation|platelet-derived growth factor receptor signaling pathway|regulation of smooth muscle cell proliferation|positive regulation of smooth muscle cell proliferation|positive regulation of epithelial cell proliferation|regulation of type B pancreatic cell proliferation|cellular response to corticotropin-releasing hormone stimulus|cellular response to catecholamine stimulus|energy homeostasis|positive regulation of monocyte aggregation|negative regulation of hydrogen peroxide-induced neuron death|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of vascular associated smooth muscle cell migration|positive regulation of feeding behavior" hsa05202 Transcriptional misregulation in cancer NR5A2 170.9360764 172.7087045 169.1634483 0.979472625 -0.029922923 0.95471729 1 1.129413814 1.087718654 2494 nuclear receptor subfamily 5 group A member 2 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003682,GO:0003700,GO:0004879,GO:0005515,GO:0005543,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006357,GO:0006367,GO:0008206,GO:0008270,GO:0009755,GO:0009792,GO:0009888,GO:0030522,GO:0030855,GO:0042127,GO:0042592,GO:0042632,GO:0043565,GO:0045070,GO:0045893,GO:0045944,GO:0061113,GO:0090575,GO:0097720,GO:1990830,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|chromatin binding|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|phospholipid binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|bile acid metabolic process|zinc ion binding|hormone-mediated signaling pathway|embryo development ending in birth or egg hatching|tissue development|intracellular receptor signaling pathway|epithelial cell differentiation|regulation of cell population proliferation|homeostatic process|cholesterol homeostasis|sequence-specific DNA binding|positive regulation of viral genome replication|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|pancreas morphogenesis|RNA polymerase II transcription regulator complex|calcineurin-mediated signaling|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding" hsa04950 Maturity onset diabetes of the young Retinoic_acid_rcpt NR6A1 312.0568108 294.4371288 329.6764929 1.119683833 0.163091413 0.605674183 1 1.721468932 1.895246814 2649 nuclear receptor subfamily 6 group A member 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0004879,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0007276,GO:0008270,GO:0030522,GO:0042803,GO:0043565,GO:0045944,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|nuclear receptor activity|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|gamete generation|zinc ion binding|intracellular receptor signaling pathway|protein homodimerization activity|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" NRARP 16.73091047 22.88910542 10.57271552 0.461910386 -1.11431511 0.229652802 1 0.462532937 0.210073645 441478 NOTCH regulated ankyrin repeat protein "GO:0000122,GO:0001569,GO:0001938,GO:0002043,GO:0005515,GO:0007219,GO:0032525,GO:0045581,GO:0045746,GO:0090263,GO:1902367" negative regulation of transcription by RNA polymerase II|branching involved in blood vessel morphogenesis|positive regulation of endothelial cell proliferation|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|protein binding|Notch signaling pathway|somite rostral/caudal axis specification|negative regulation of T cell differentiation|negative regulation of Notch signaling pathway|positive regulation of canonical Wnt signaling pathway|negative regulation of Notch signaling pathway involved in somitogenesis NRAS 2667.845989 2590.630568 2745.06141 1.059611295 0.083535127 0.724932199 1 31.95959131 33.29806331 4893 "NRAS proto-oncogene, GTPase" "GO:0000139,GO:0000165,GO:0001938,GO:0002223,GO:0003924,GO:0005515,GO:0005525,GO:0005794,GO:0005886,GO:0007265,GO:0016020,GO:0019003,GO:0043312,GO:0044877,GO:0070062,GO:0070821" Golgi membrane|MAPK cascade|positive regulation of endothelial cell proliferation|stimulatory C-type lectin receptor signaling pathway|GTPase activity|protein binding|GTP binding|Golgi apparatus|plasma membrane|Ras protein signal transduction|membrane|GDP binding|neutrophil degranulation|protein-containing complex binding|extracellular exosome|tertiary granule membrane "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04062,hsa04068,hsa04071,hsa04072,hsa04137,hsa04140,hsa04150,hsa04151,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04371,hsa04540,hsa04550,hsa04625,hsa04650,hsa04660,hsa04662,hsa04664,hsa04714,hsa04720,hsa04722,hsa04725,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04929,hsa04933,hsa04935,hsa05010,hsa05022,hsa05034,hsa05160,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05170,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Mitophagy - animal|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Apelin signaling pathway|Gap junction|Signaling pathways regulating pluripotency of stem cells|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|GnRH secretion|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" NRBF2 1001.810856 979.0294636 1024.592249 1.046538728 0.0656257 0.792877153 1 25.6248176 26.36861174 29982 nuclear receptor binding factor 2 "GO:0005515,GO:0005654,GO:0005737,GO:0005776,GO:0006367,GO:0006914,GO:0031410,GO:0034976,GO:0035032,GO:0043550" "protein binding|nucleoplasm|cytoplasm|autophagosome|transcription initiation from RNA polymerase II promoter|autophagy|cytoplasmic vesicle|response to endoplasmic reticulum stress|phosphatidylinositol 3-kinase complex, class III|regulation of lipid kinase activity" "hsa04140,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022" Autophagy - animal|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases NRBP1 1916.502506 2093.312732 1739.69228 0.83107137 -0.266955718 0.259606276 1 38.37727693 31.36054894 29959 nuclear receptor binding protein 1 "GO:0004674,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005938,GO:0006367,GO:0006468,GO:0006888,GO:0012505,GO:0016020,GO:0030027,GO:0035556,GO:0042803" protein serine/threonine kinase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|cell cortex|transcription initiation from RNA polymerase II promoter|protein phosphorylation|endoplasmic reticulum to Golgi vesicle-mediated transport|endomembrane system|membrane|lamellipodium|intracellular signal transduction|protein homodimerization activity NRBP2 929.8531074 957.180772 902.5254427 0.942899679 -0.084823813 0.735031666 1 10.23706986 9.491007865 340371 nuclear receptor binding protein 2 "GO:0004674,GO:0005524,GO:0005737,GO:0006468,GO:0006888,GO:0012505,GO:0016242,GO:0030182,GO:0035556,GO:0043524" protein serine/threonine kinase activity|ATP binding|cytoplasm|protein phosphorylation|endoplasmic reticulum to Golgi vesicle-mediated transport|endomembrane system|negative regulation of macroautophagy|neuron differentiation|intracellular signal transduction|negative regulation of neuron apoptotic process NRCAM 191.9821278 220.5677431 163.3965125 0.740799675 -0.432844628 0.24178043 1 0.838112856 0.610484251 4897 neuronal cell adhesion molecule "GO:0001525,GO:0001764,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0007409,GO:0007411,GO:0007413,GO:0007416,GO:0007417,GO:0009897,GO:0030506,GO:0030516,GO:0043005,GO:0043194,GO:0045162,GO:0045666,GO:0098609" angiogenesis|neuron migration|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|axonogenesis|axon guidance|axonal fasciculation|synapse assembly|central nervous system development|external side of plasma membrane|ankyrin binding|regulation of axon extension|neuron projection|axon initial segment|clustering of voltage-gated sodium channels|positive regulation of neuron differentiation|cell-cell adhesion hsa04514 Cell adhesion molecules NRDC 4175.265237 4264.656505 4085.873969 0.958078092 -0.061784841 0.796291863 1 59.02408702 55.60340231 4898 nardilysin convertase "GO:0004222,GO:0005515,GO:0005739,GO:0005829,GO:0006508,GO:0009986,GO:0046872,GO:0048408,GO:0051044,GO:0052548,GO:0120163" metalloendopeptidase activity|protein binding|mitochondrion|cytosol|proteolysis|cell surface|metal ion binding|epidermal growth factor binding|positive regulation of membrane protein ectodomain proteolysis|regulation of endopeptidase activity|negative regulation of cold-induced thermogenesis NRDE2 348.6499343 321.4878897 375.8119788 1.168977093 0.225246659 0.457073469 1 1.212524227 1.393694558 55051 "NRDE-2, necessary for RNA interference, domain containing" "GO:0003674,GO:0005515,GO:0005654,GO:0005730,GO:0016246,GO:0016607,GO:0031048,GO:0046833,GO:1902369" molecular_function|protein binding|nucleoplasm|nucleolus|RNA interference|nuclear speck|heterochromatin assembly by small RNA|positive regulation of RNA export from nucleus|negative regulation of RNA catabolic process NREP 433.5826743 444.2567279 422.9086206 0.951946463 -0.071047656 0.808940729 1 6.303952422 5.900606179 9315 neuronal regeneration related protein "GO:0005515,GO:0005634,GO:0005737,GO:0017015,GO:0031103,GO:0045664" protein binding|nucleus|cytoplasm|regulation of transforming growth factor beta receptor signaling pathway|axon regeneration|regulation of neuron differentiation NRF1 361.6796455 385.9935505 337.3657406 0.874019113 -0.194263266 0.517571256 1 5.599284143 4.811988883 4899 nuclear respiratory factor 1 "GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007005,GO:0042803,GO:0045944,GO:0070062" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|mitochondrion organization|protein homodimerization activity|positive regulation of transcription by RNA polymerase II|extracellular exosome" "hsa04371,hsa05016" Apelin signaling pathway|Huntington disease Nrf1 NRG1 1064.983609 1136.13196 993.8352585 0.874753368 -0.193051781 0.430653103 1 4.14558147 3.565679107 3084 neuregulin 1 "GO:0000165,GO:0000187,GO:0003222,GO:0003712,GO:0005102,GO:0005125,GO:0005178,GO:0005576,GO:0005615,GO:0005654,GO:0005886,GO:0007154,GO:0007171,GO:0007399,GO:0008083,GO:0008284,GO:0014032,GO:0016020,GO:0016021,GO:0030154,GO:0030296,GO:0030297,GO:0030879,GO:0030971,GO:0031334,GO:0032148,GO:0035556,GO:0038127,GO:0038128,GO:0038129,GO:0042060,GO:0043125,GO:0045499,GO:0045892,GO:0048513,GO:0050919,GO:0051048,GO:0051155,GO:0051897,GO:0055007,GO:0060379,GO:0060956,GO:0061098,GO:2000145" "MAPK cascade|activation of MAPK activity|ventricular trabecula myocardium morphogenesis|transcription coregulator activity|signaling receptor binding|cytokine activity|integrin binding|extracellular region|extracellular space|nucleoplasm|plasma membrane|cell communication|activation of transmembrane receptor protein tyrosine kinase activity|nervous system development|growth factor activity|positive regulation of cell population proliferation|neural crest cell development|membrane|integral component of membrane|cell differentiation|protein tyrosine kinase activator activity|transmembrane receptor protein tyrosine kinase activator activity|mammary gland development|receptor tyrosine kinase binding|positive regulation of protein-containing complex assembly|activation of protein kinase B activity|intracellular signal transduction|ERBB signaling pathway|ERBB2 signaling pathway|ERBB3 signaling pathway|wound healing|ErbB-3 class receptor binding|chemorepellent activity|negative regulation of transcription, DNA-templated|animal organ development|negative chemotaxis|negative regulation of secretion|positive regulation of striated muscle cell differentiation|positive regulation of protein kinase B signaling|cardiac muscle cell differentiation|cardiac muscle cell myoblast differentiation|endocardial cell differentiation|positive regulation of protein tyrosine kinase activity|regulation of cell motility" "hsa01521,hsa04012,hsa05014" EGFR tyrosine kinase inhibitor resistance|ErbB signaling pathway|Amyotrophic lateral sclerosis NRG2 417.6047141 441.1354862 394.073942 0.893317256 -0.162755465 0.573286135 1 2.723891025 2.392580894 9542 neuregulin 2 "GO:0000165,GO:0005102,GO:0005576,GO:0005615,GO:0005886,GO:0007165,GO:0007399,GO:0008083,GO:0016021,GO:0035556,GO:0038128,GO:0048513,GO:0051897,GO:2000145" MAPK cascade|signaling receptor binding|extracellular region|extracellular space|plasma membrane|signal transduction|nervous system development|growth factor activity|integral component of membrane|intracellular signal transduction|ERBB2 signaling pathway|animal organ development|positive regulation of protein kinase B signaling|regulation of cell motility "hsa01521,hsa04012,hsa05014" EGFR tyrosine kinase inhibitor resistance|ErbB signaling pathway|Amyotrophic lateral sclerosis NRGN 488.0465016 448.4183834 527.6746198 1.17674618 0.23480317 0.394851404 1 19.72899008 22.82752517 4900 neurogranin "GO:0005516,GO:0005547,GO:0005634,GO:0005829,GO:0007165,GO:0007399,GO:0008306,GO:0012510,GO:0014069,GO:0021537,GO:0030424,GO:0031966,GO:0043025,GO:0044327,GO:0045211,GO:0070300,GO:0098978,GO:0099170,GO:1900273" "calmodulin binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|cytosol|signal transduction|nervous system development|associative learning|trans-Golgi network transport vesicle membrane|postsynaptic density|telencephalon development|axon|mitochondrial membrane|neuronal cell body|dendritic spine head|postsynaptic membrane|phosphatidic acid binding|glutamatergic synapse|postsynaptic modulation of chemical synaptic transmission|positive regulation of long-term synaptic potentiation" NRIP1 3641.287039 3708.035078 3574.539 0.963998162 -0.052897699 0.824725716 1 23.34170996 22.12483562 8204 nuclear receptor interacting protein 1 "GO:0000118,GO:0000122,GO:0000785,GO:0000978,GO:0001543,GO:0001650,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0007623,GO:0016607,GO:0019915,GO:0030331,GO:0032922,GO:0035257,GO:0035259,GO:0042826,GO:0045944,GO:0046965,GO:0071392" histone deacetylase complex|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|ovarian follicle rupture|fibrillar center|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|circadian rhythm|nuclear speck|lipid storage|estrogen receptor binding|circadian regulation of gene expression|nuclear hormone receptor binding|glucocorticoid receptor binding|histone deacetylase binding|positive regulation of transcription by RNA polymerase II|retinoid X receptor binding|cellular response to estradiol stimulus other NRIP3 1712.627273 1472.185644 1953.068903 1.326645801 0.407783239 0.085981097 1 19.22384195 25.0764672 56675 nuclear receptor interacting protein 3 "GO:0004190,GO:0005515,GO:0006508" aspartic-type endopeptidase activity|protein binding|proteolysis NRK 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.007110382 0.025835202 203447 Nik related kinase "GO:0000165,GO:0004674,GO:0005524,GO:0005737,GO:0006468,GO:0007165,GO:0031098,GO:0031532,GO:0032147,GO:0048812,GO:0106310,GO:0106311" MAPK cascade|protein serine/threonine kinase activity|ATP binding|cytoplasm|protein phosphorylation|signal transduction|stress-activated protein kinase signaling cascade|actin cytoskeleton reorganization|activation of protein kinase activity|neuron projection morphogenesis|protein serine kinase activity|protein threonine kinase activity NRL 5.444873611 4.161655531 6.728091692 1.616686351 0.693039812 0.747994079 1 0.039953212 0.063510956 4901 neural retina leucine zipper "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0007601,GO:0043522,GO:0045944,GO:0046548,GO:0050896,GO:1990837,GO:1990841" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|visual perception|leucine zipper domain binding|positive regulation of transcription by RNA polymerase II|retinal rod cell development|response to stimulus|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding" NRM 538.1945736 528.5302524 547.8588949 1.036570551 0.051818312 0.853716515 1 14.21708073 14.49040335 11270 nurim "GO:0003674,GO:0005515,GO:0005635,GO:0005637,GO:0008150,GO:0016020,GO:0016021,GO:0031965" molecular_function|protein binding|nuclear envelope|nuclear inner membrane|biological_process|membrane|integral component of membrane|nuclear membrane NRN1L 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.272515223 0.123771221 123904 neuritin 1 like "GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0030424,GO:0042802,GO:0046658,GO:1990138" protein binding|extracellular region|extracellular space|plasma membrane|axon|identical protein binding|anchored component of plasma membrane|neuron projection extension NRP1 2655.854234 2931.886321 2379.822147 0.811703418 -0.300975407 0.203089637 1 25.72240414 20.52958217 8829 neuropilin 1 "GO:0001525,GO:0001569,GO:0001764,GO:0001938,GO:0002040,GO:0002042,GO:0002116,GO:0003148,GO:0005021,GO:0005096,GO:0005515,GO:0005615,GO:0005769,GO:0005829,GO:0005886,GO:0005925,GO:0006930,GO:0007165,GO:0007229,GO:0007267,GO:0007411,GO:0008201,GO:0009611,GO:0009887,GO:0009986,GO:0010595,GO:0014911,GO:0015026,GO:0016021,GO:0017154,GO:0019838,GO:0019955,GO:0021675,GO:0030424,GO:0030426,GO:0031290,GO:0031410,GO:0031532,GO:0031966,GO:0032489,GO:0034446,GO:0035729,GO:0035767,GO:0035924,GO:0038085,GO:0038189,GO:0038190,GO:0042327,GO:0043005,GO:0043025,GO:0043235,GO:0043542,GO:0043547,GO:0046718,GO:0046872,GO:0048008,GO:0048010,GO:0048012,GO:0048842,GO:0048843,GO:0048844,GO:0048846,GO:0050731,GO:0050918,GO:0051491,GO:0051496,GO:0051894,GO:0060301,GO:0060385,GO:0060627,GO:0060978,GO:0061299,GO:0061549,GO:0070374,GO:0071526,GO:0071679,GO:0090259,GO:0097102,GO:0097443,GO:0097475,GO:0097490,GO:0097491,GO:0150018,GO:0150020,GO:1900026,GO:1901166,GO:1902285,GO:1902336,GO:1902946,GO:2000251" "angiogenesis|branching involved in blood vessel morphogenesis|neuron migration|positive regulation of endothelial cell proliferation|sprouting angiogenesis|cell migration involved in sprouting angiogenesis|semaphorin receptor complex|outflow tract septum morphogenesis|vascular endothelial growth factor-activated receptor activity|GTPase activator activity|protein binding|extracellular space|early endosome|cytosol|plasma membrane|focal adhesion|substrate-dependent cell migration, cell extension|signal transduction|integrin-mediated signaling pathway|cell-cell signaling|axon guidance|heparin binding|response to wounding|animal organ morphogenesis|cell surface|positive regulation of endothelial cell migration|positive regulation of smooth muscle cell migration|coreceptor activity|integral component of membrane|semaphorin receptor activity|growth factor binding|cytokine binding|nerve development|axon|growth cone|retinal ganglion cell axon guidance|cytoplasmic vesicle|actin cytoskeleton reorganization|mitochondrial membrane|regulation of Cdc42 protein signal transduction|substrate adhesion-dependent cell spreading|cellular response to hepatocyte growth factor stimulus|endothelial cell chemotaxis|cellular response to vascular endothelial growth factor stimulus|vascular endothelial growth factor binding|neuropilin signaling pathway|VEGF-activated neuropilin signaling pathway|positive regulation of phosphorylation|neuron projection|neuronal cell body|receptor complex|endothelial cell migration|positive regulation of GTPase activity|viral entry into host cell|metal ion binding|platelet-derived growth factor receptor signaling pathway|vascular endothelial growth factor receptor signaling pathway|hepatocyte growth factor receptor signaling pathway|positive regulation of axon extension involved in axon guidance|negative regulation of axon extension involved in axon guidance|artery morphogenesis|axon extension involved in axon guidance|positive regulation of peptidyl-tyrosine phosphorylation|positive chemotaxis|positive regulation of filopodium assembly|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|positive regulation of cytokine activity|axonogenesis involved in innervation|regulation of vesicle-mediated transport|angiogenesis involved in coronary vascular morphogenesis|retina vasculature morphogenesis in camera-type eye|sympathetic ganglion development|positive regulation of ERK1 and ERK2 cascade|semaphorin-plexin signaling pathway|commissural neuron axon guidance|regulation of retinal ganglion cell axon guidance|endothelial tip cell fate specification|sorting endosome|motor neuron migration|sympathetic neuron projection extension|sympathetic neuron projection guidance|basal dendrite development|basal dendrite arborization|positive regulation of substrate adhesion-dependent cell spreading|neural crest cell migration involved in autonomic nervous system development|semaphorin-plexin signaling pathway involved in neuron projection guidance|positive regulation of retinal ganglion cell axon guidance|protein localization to early endosome|positive regulation of actin cytoskeleton reorganization" "hsa04360,hsa05166,hsa05171" Axon guidance|Human T-cell leukemia virus 1 infection|Coronavirus disease - COVID-19 NRP2 1108.680378 1324.446873 892.9138831 0.674178709 -0.568797027 0.019657283 0.807247285 4.343860334 2.879533034 8828 neuropilin 2 "GO:0001525,GO:0001938,GO:0002116,GO:0003148,GO:0005021,GO:0005515,GO:0005576,GO:0005886,GO:0007155,GO:0007411,GO:0008201,GO:0010595,GO:0016020,GO:0016021,GO:0016032,GO:0017154,GO:0019838,GO:0019955,GO:0021612,GO:0021649,GO:0021675,GO:0021828,GO:0030424,GO:0036486,GO:0038023,GO:0038084,GO:0046872,GO:0048010,GO:0048846,GO:0050919,GO:0061549,GO:0061551,GO:0097374,GO:0097490,GO:0097491,GO:0098978,GO:0099055,GO:0099175,GO:1901166,GO:1902285,GO:1903375,GO:1904835,GO:1990830" angiogenesis|positive regulation of endothelial cell proliferation|semaphorin receptor complex|outflow tract septum morphogenesis|vascular endothelial growth factor-activated receptor activity|protein binding|extracellular region|plasma membrane|cell adhesion|axon guidance|heparin binding|positive regulation of endothelial cell migration|membrane|integral component of membrane|viral process|semaphorin receptor activity|growth factor binding|cytokine binding|facial nerve structural organization|vestibulocochlear nerve structural organization|nerve development|gonadotrophin-releasing hormone neuronal migration to the hypothalamus|axon|ventral trunk neural crest cell migration|signaling receptor activity|vascular endothelial growth factor signaling pathway|metal ion binding|vascular endothelial growth factor receptor signaling pathway|axon extension involved in axon guidance|negative chemotaxis|sympathetic ganglion development|trigeminal ganglion development|sensory neuron axon guidance|sympathetic neuron projection extension|sympathetic neuron projection guidance|glutamatergic synapse|integral component of postsynaptic membrane|regulation of postsynapse organization|neural crest cell migration involved in autonomic nervous system development|semaphorin-plexin signaling pathway involved in neuron projection guidance|facioacoustic ganglion development|dorsal root ganglion morphogenesis|cellular response to leukemia inhibitory factor NRROS 19.77289419 27.05076095 12.49502743 0.461910386 -1.11431511 0.196488012 1 0.564808057 0.256525055 375387 negative regulator of reactive oxygen species "GO:0005576,GO:0005783,GO:0005789,GO:0005886,GO:0006801,GO:0006954,GO:0006955,GO:0007179,GO:0009986,GO:0014005,GO:0016021,GO:0035583,GO:0036364,GO:0045087,GO:0050431" extracellular region|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|superoxide metabolic process|inflammatory response|immune response|transforming growth factor beta receptor signaling pathway|cell surface|microglia development|integral component of membrane|sequestering of TGFbeta in extracellular matrix|transforming growth factor beta1 activation|innate immune response|transforming growth factor beta binding NRSN2 755.6875776 649.2182628 862.1568925 1.327992359 0.409246846 0.106418677 1 8.288896046 10.82339349 80023 neurensin 2 "GO:0003674,GO:0005515,GO:0005886,GO:0007399,GO:0008150,GO:0016021,GO:0030133,GO:0043005,GO:0043025" molecular_function|protein binding|plasma membrane|nervous system development|biological_process|integral component of membrane|transport vesicle|neuron projection|neuronal cell body NRTN 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.072676671 0.099025077 4902 neurturin "GO:0000165,GO:0001755,GO:0005102,GO:0005576,GO:0007169,GO:0007399,GO:0007411,GO:0008083,GO:0021675,GO:0030116,GO:0030424,GO:0030971,GO:0031175" MAPK cascade|neural crest cell migration|signaling receptor binding|extracellular region|transmembrane receptor protein tyrosine kinase signaling pathway|nervous system development|axon guidance|growth factor activity|nerve development|glial cell-derived neurotrophic factor receptor binding|axon|receptor tyrosine kinase binding|neuron projection development NRXN1 2.40288989 0 4.80577978 Inf Inf 0.18976424 1 0 0.018279491 9378 neurexin 1 "GO:0005246,GO:0005509,GO:0005515,GO:0005730,GO:0005783,GO:0005886,GO:0005887,GO:0007158,GO:0007268,GO:0007269,GO:0007411,GO:0007416,GO:0007612,GO:0009986,GO:0030534,GO:0031965,GO:0031982,GO:0033130,GO:0035176,GO:0038023,GO:0042297,GO:0042734,GO:0042995,GO:0043025,GO:0050839,GO:0050885,GO:0051965,GO:0051968,GO:0071625,GO:0090129,GO:0097104,GO:0097109,GO:0097116,GO:0097118,GO:0097119,GO:2000463" "calcium channel regulator activity|calcium ion binding|protein binding|nucleolus|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|neuron cell-cell adhesion|chemical synaptic transmission|neurotransmitter secretion|axon guidance|synapse assembly|learning|cell surface|adult behavior|nuclear membrane|vesicle|acetylcholine receptor binding|social behavior|signaling receptor activity|vocal learning|presynaptic membrane|cell projection|neuronal cell body|cell adhesion molecule binding|neuromuscular process controlling balance|positive regulation of synapse assembly|positive regulation of synaptic transmission, glutamatergic|vocalization behavior|positive regulation of synapse maturation|postsynaptic membrane assembly|neuroligin family protein binding|gephyrin clustering involved in postsynaptic density assembly|neuroligin clustering involved in postsynaptic membrane assembly|postsynaptic density protein 95 clustering|positive regulation of excitatory postsynaptic potential" hsa04514 Cell adhesion molecules NRXN3 75.94076698 75.95021343 75.93132052 0.999751246 -0.000358921 1 1 0.282382841 0.277588478 9369 neurexin 3 "GO:0005886,GO:0005887,GO:0007158,GO:0007411,GO:0007612,GO:0030534,GO:0035176,GO:0038023,GO:0046872,GO:0050839,GO:0071625,GO:0097109" plasma membrane|integral component of plasma membrane|neuron cell-cell adhesion|axon guidance|learning|adult behavior|social behavior|signaling receptor activity|metal ion binding|cell adhesion molecule binding|vocalization behavior|neuroligin family protein binding hsa04514 Cell adhesion molecules NSA2 1982.169311 1924.765683 2039.572939 1.059647393 0.083584276 0.725404994 1 22.73599091 23.68898427 10412 NSA2 ribosome biogenesis factor "GO:0000460,GO:0000470,GO:0003723,GO:0005730,GO:0030687" "maturation of 5.8S rRNA|maturation of LSU-rRNA|RNA binding|nucleolus|preribosome, large subunit precursor" NSD1 1648.930627 1919.563613 1378.297641 0.718026551 -0.477890902 0.044480203 1 7.495140624 5.291654343 64324 nuclear receptor binding SET domain protein 1 "GO:0000122,GO:0000414,GO:0000785,GO:0000978,GO:0003682,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0008270,GO:0010452,GO:0016571,GO:0030331,GO:0033135,GO:0034770,GO:0042799,GO:0042974,GO:0045893,GO:0046965,GO:0046966,GO:0046975,GO:0050681,GO:1903025" "negative regulation of transcription by RNA polymerase II|regulation of histone H3-K36 methylation|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|chromatin binding|transcription coregulator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|zinc ion binding|histone H3-K36 methylation|histone methylation|estrogen receptor binding|regulation of peptidyl-serine phosphorylation|histone H4-K20 methylation|histone methyltransferase activity (H4-K20 specific)|retinoic acid receptor binding|positive regulation of transcription, DNA-templated|retinoid X receptor binding|thyroid hormone receptor binding|histone methyltransferase activity (H3-K36 specific)|androgen receptor binding|regulation of RNA polymerase II regulatory region sequence-specific DNA binding" hsa00310 Lysine degradation NSD2 6538.661947 6962.449703 6114.874192 0.878264756 -0.187272183 0.441657834 1 23.92615223 20.66186386 7468 nuclear receptor binding SET domain protein 2 "GO:0000122,GO:0000785,GO:0003149,GO:0003289,GO:0003290,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006303,GO:0006355,GO:0010452,GO:0034770,GO:0042799,GO:0043565,GO:0046872,GO:0046975,GO:0048298,GO:0060348,GO:0070201,GO:2001032" "negative regulation of transcription by RNA polymerase II|chromatin|membranous septum morphogenesis|atrial septum primum morphogenesis|atrial septum secundum morphogenesis|chromatin binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|double-strand break repair via nonhomologous end joining|regulation of transcription, DNA-templated|histone H3-K36 methylation|histone H4-K20 methylation|histone methyltransferase activity (H4-K20 specific)|sequence-specific DNA binding|metal ion binding|histone methyltransferase activity (H3-K36 specific)|positive regulation of isotype switching to IgA isotypes|bone development|regulation of establishment of protein localization|regulation of double-strand break repair via nonhomologous end joining" "hsa00310,hsa05202" Lysine degradation|Transcriptional misregulation in cancer NSD3 1934.651227 1976.786377 1892.516077 0.957370052 -0.062851417 0.792373151 1 8.51472605 8.015335333 54904 nuclear receptor binding SET domain protein 3 "GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0010452,GO:0016571,GO:0018024,GO:0045893,GO:0046872,GO:0046975,GO:0140537,GO:2001255" "chromatin|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|histone H3-K36 methylation|histone methylation|histone-lysine N-methyltransferase activity|positive regulation of transcription, DNA-templated|metal ion binding|histone methyltransferase activity (H3-K36 specific)|transcription regulator activator activity|positive regulation of histone H3-K36 trimethylation" hsa00310 Lysine degradation NSDHL 971.0393889 915.5642167 1026.514561 1.121182482 0.165021108 0.504774737 1 27.55892809 30.38154139 50814 NAD(P) dependent steroid dehydrogenase-like "GO:0000252,GO:0001942,GO:0003854,GO:0005515,GO:0005783,GO:0005789,GO:0005811,GO:0006695,GO:0007224,GO:0008203,GO:0016021,GO:0016616,GO:0047012,GO:0055114,GO:0060716,GO:0103066,GO:0103067" "C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity|hair follicle development|3-beta-hydroxy-delta5-steroid dehydrogenase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|cholesterol biosynthetic process|smoothened signaling pathway|cholesterol metabolic process|integral component of membrane|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity|oxidation-reduction process|labyrinthine layer blood vessel development|4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity|4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity" hsa00100 Steroid biosynthesis NSF 800.1618343 895.796353 704.5273157 0.786481563 -0.346515149 0.168400806 1 12.00276298 9.28198698 4905 "N-ethylmaleimide sensitive factor, vesicle fusing ATPase" "GO:0000139,GO:0000149,GO:0001921,GO:0005515,GO:0005524,GO:0005765,GO:0005794,GO:0005795,GO:0005829,GO:0005886,GO:0006813,GO:0006886,GO:0006887,GO:0006888,GO:0006890,GO:0006891,GO:0014069,GO:0016192,GO:0016887,GO:0017075,GO:0017157,GO:0019901,GO:0030165,GO:0031267,GO:0035255,GO:0035494,GO:0043001,GO:0043198,GO:0044877,GO:0045026,GO:0045732,GO:0046872,GO:0048208,GO:0048211" "Golgi membrane|SNARE binding|positive regulation of receptor recycling|protein binding|ATP binding|lysosomal membrane|Golgi apparatus|Golgi stack|cytosol|plasma membrane|potassium ion transport|intracellular protein transport|exocytosis|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|postsynaptic density|vesicle-mediated transport|ATPase activity|syntaxin-1 binding|regulation of exocytosis|protein kinase binding|PDZ domain binding|small GTPase binding|ionotropic glutamate receptor binding|SNARE complex disassembly|Golgi to plasma membrane protein transport|dendritic shaft|protein-containing complex binding|plasma membrane fusion|positive regulation of protein catabolic process|metal ion binding|COPII vesicle coating|Golgi vesicle docking" "hsa04721,hsa04727,hsa04962" Synaptic vesicle cycle|GABAergic synapse|Vasopressin-regulated water reabsorption NSFL1C 2484.771546 2427.285588 2542.257504 1.047366456 0.066766305 0.77889903 1 27.87599972 28.70782503 55968 NSFL1 cofactor "GO:0000045,GO:0000132,GO:0005515,GO:0005543,GO:0005634,GO:0005654,GO:0005694,GO:0005795,GO:0005829,GO:0005886,GO:0007030,GO:0031468,GO:0031616,GO:0043130,GO:0043161,GO:0045111,GO:0046604,GO:0051117,GO:0061025,GO:1904780,GO:1990730" autophagosome assembly|establishment of mitotic spindle orientation|protein binding|phospholipid binding|nucleus|nucleoplasm|chromosome|Golgi stack|cytosol|plasma membrane|Golgi organization|nuclear envelope reassembly|spindle pole centrosome|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|intermediate filament cytoskeleton|positive regulation of mitotic centrosome separation|ATPase binding|membrane fusion|negative regulation of protein localization to centrosome|VCP-NSFL1C complex hsa04141 Protein processing in endoplasmic reticulum NSG1 11.13255142 2.080827765 20.18427508 9.700118103 3.278002313 0.010138245 0.610531935 0.044207784 0.421644992 27065 neuronal vesicle trafficking associated 1 "GO:0001881,GO:0001921,GO:0005102,GO:0005515,GO:0005634,GO:0005737,GO:0005768,GO:0005770,GO:0005783,GO:0005789,GO:0006915,GO:0007212,GO:0016021,GO:0016197,GO:0016328,GO:0030425,GO:0030659,GO:0031901,GO:0032051,GO:0032580,GO:0032585,GO:0032588,GO:0036477,GO:0042982,GO:0043202,GO:0045211,GO:0048268,GO:0055038,GO:0098814,GO:0098845,GO:0098887,GO:0098978,GO:0099003,GO:0099627,GO:0099630,GO:1900271" "receptor recycling|positive regulation of receptor recycling|signaling receptor binding|protein binding|nucleus|cytoplasm|endosome|late endosome|endoplasmic reticulum|endoplasmic reticulum membrane|apoptotic process|dopamine receptor signaling pathway|integral component of membrane|endosomal transport|lateral plasma membrane|dendrite|cytoplasmic vesicle membrane|early endosome membrane|clathrin light chain binding|Golgi cisterna membrane|multivesicular body membrane|trans-Golgi network membrane|somatodendritic compartment|amyloid precursor protein metabolic process|lysosomal lumen|postsynaptic membrane|clathrin coat assembly|recycling endosome membrane|spontaneous synaptic transmission|postsynaptic endosome|neurotransmitter receptor transport, endosome to postsynaptic membrane|glutamatergic synapse|vesicle-mediated transport in synapse|neurotransmitter receptor cycle|postsynaptic neurotransmitter receptor cycle|regulation of long-term synaptic potentiation" NSL1 732.748168 728.2897178 737.2066182 1.012243617 0.017556546 0.95084221 1 2.575711312 2.563618582 25936 NSL1 component of MIS12 kinetochore complex "GO:0000070,GO:0000444,GO:0000777,GO:0005515,GO:0005829,GO:0016607,GO:0051301" mitotic sister chromatid segregation|MIS12/MIND type complex|condensed chromosome kinetochore|protein binding|cytosol|nuclear speck|cell division NSMAF 1802.096608 1865.462092 1738.731124 0.932064571 -0.10149819 0.669939554 1 26.26121953 24.06756033 8439 neutral sphingomyelinase activation associated factor "GO:0005515,GO:0005737,GO:0005829,GO:0006672,GO:0007165,GO:0016230,GO:0043065,GO:0050790,GO:2000304" protein binding|cytoplasm|cytosol|ceramide metabolic process|signal transduction|sphingomyelin phosphodiesterase activator activity|positive regulation of apoptotic process|regulation of catalytic activity|positive regulation of ceramide biosynthetic process hsa04071 Sphingolipid signaling pathway NSMCE1 1162.85294 1156.940237 1168.765642 1.010221276 0.014671331 0.955668167 1 34.84411631 34.61123882 197370 "NSE1 homolog, SMC5-SMC6 complex component" "GO:0000724,GO:0000781,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0006301,GO:0016567,GO:0030915,GO:0035556,GO:0043231,GO:0046872,GO:0046983,GO:0061630,GO:2001022" "double-strand break repair via homologous recombination|chromosome, telomeric region|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|postreplication repair|protein ubiquitination|Smc5-Smc6 complex|intracellular signal transduction|intracellular membrane-bounded organelle|metal ion binding|protein dimerization activity|ubiquitin protein ligase activity|positive regulation of response to DNA damage stimulus" NSMCE2 675.7034276 668.9861265 682.4207288 1.020082034 0.028685177 0.917315875 1 8.4124788 8.43782007 286053 "NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase" "GO:0000722,GO:0000724,GO:0000781,GO:0005515,GO:0005634,GO:0005654,GO:0006303,GO:0007049,GO:0008270,GO:0016604,GO:0016605,GO:0016925,GO:0019789,GO:0030915,GO:0034184,GO:0045842,GO:0051301,GO:0061665,GO:0090398" "telomere maintenance via recombination|double-strand break repair via homologous recombination|chromosome, telomeric region|protein binding|nucleus|nucleoplasm|double-strand break repair via nonhomologous end joining|cell cycle|zinc ion binding|nuclear body|PML body|protein sumoylation|SUMO transferase activity|Smc5-Smc6 complex|positive regulation of maintenance of mitotic sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|cell division|SUMO ligase activity|cellular senescence" NSMCE3 274.2301591 247.6185041 300.8418142 1.214940763 0.280885974 0.390130722 1 2.733749371 3.26576536 56160 "NSE3 homolog, SMC5-SMC6 complex component" "GO:0000781,GO:0005515,GO:0005654,GO:0005737,GO:0006281,GO:0006310,GO:0030915,GO:0031398,GO:0034644,GO:0040008,GO:0046983,GO:0071478,GO:0072711" "chromosome, telomeric region|protein binding|nucleoplasm|cytoplasm|DNA repair|DNA recombination|Smc5-Smc6 complex|positive regulation of protein ubiquitination|cellular response to UV|regulation of growth|protein dimerization activity|cellular response to radiation|cellular response to hydroxyurea" NSMCE4A 503.9250822 499.3986637 508.4515007 1.018127476 0.025918207 0.932050179 1 12.14767038 12.16091731 54780 "NSE4 homolog A, SMC5-SMC6 complex component" "GO:0000781,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006310,GO:0016604,GO:0030915,GO:2001022" "chromosome, telomeric region|protein binding|nucleus|nucleoplasm|DNA repair|DNA recombination|nuclear body|Smc5-Smc6 complex|positive regulation of response to DNA damage stimulus" NSMF 2530.693181 2560.458565 2500.927797 0.976749959 -0.033938806 0.887434481 1 36.35194671 34.91260486 26012 NMDA receptor synaptonuclear signaling and neuronal migration factor "GO:0000791,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005886,GO:0014069,GO:0016020,GO:0016363,GO:0030425,GO:0030863,GO:0031965,GO:0035307,GO:0043005,GO:0043204,GO:0043523,GO:0045202,GO:0048168,GO:0048306,GO:0048814,GO:0071230,GO:0071257,GO:0071371,GO:0097440,GO:2001224" euchromatin|nucleus|nuclear envelope|nucleoplasm|cytoplasm|plasma membrane|postsynaptic density|membrane|nuclear matrix|dendrite|cortical cytoskeleton|nuclear membrane|positive regulation of protein dephosphorylation|neuron projection|perikaryon|regulation of neuron apoptotic process|synapse|regulation of neuronal synaptic plasticity|calcium-dependent protein binding|regulation of dendrite morphogenesis|cellular response to amino acid stimulus|cellular response to electrical stimulus|cellular response to gonadotropin stimulus|apical dendrite|positive regulation of neuron migration NSRP1 381.0216515 389.1147921 372.9285109 0.958402298 -0.061296728 0.84265616 1 9.912334746 9.34103469 84081 nuclear speckle splicing regulatory protein 1 "GO:0000381,GO:0001701,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0006397,GO:0008380,GO:0016607,GO:0032502,GO:1990904" "regulation of alternative mRNA splicing, via spliceosome|in utero embryonic development|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|mRNA processing|RNA splicing|nuclear speck|developmental process|ribonucleoprotein complex" NSUN2 2508.214842 2588.54974 2427.879945 0.937930575 -0.092446956 0.696749141 1 45.20488942 41.68955726 54888 NOP2/Sun RNA methyltransferase 2 "GO:0000049,GO:0001510,GO:0001701,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005819,GO:0006400,GO:0007286,GO:0008168,GO:0010793,GO:0016428,GO:0030488,GO:0033313,GO:0033391,GO:0036416,GO:0048820,GO:0051301,GO:0062152,GO:0070062,GO:0080009,GO:2000736" tRNA binding|RNA methylation|in utero embryonic development|RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|spindle|tRNA modification|spermatid development|methyltransferase activity|regulation of mRNA export from nucleus|tRNA (cytosine-5-)-methyltransferase activity|tRNA methylation|meiotic cell cycle checkpoint|chromatoid body|tRNA stabilization|hair follicle maturation|cell division|mRNA (cytidine-5-)-methyltransferase activity|extracellular exosome|mRNA methylation|regulation of stem cell differentiation NSUN3 222.0553652 227.8506403 216.2600901 0.94913093 -0.075320978 0.841269796 1 1.923132991 1.794760997 63899 NOP2/Sun RNA methyltransferase 3 "GO:0000049,GO:0001510,GO:0002127,GO:0005739,GO:0005759,GO:0005762,GO:0008168,GO:0016428,GO:0031167,GO:0070129" tRNA binding|RNA methylation|tRNA wobble base cytosine methylation|mitochondrion|mitochondrial matrix|mitochondrial large ribosomal subunit|methyltransferase activity|tRNA (cytosine-5-)-methyltransferase activity|rRNA methylation|regulation of mitochondrial translation NSUN4 490.3695192 547.2577023 433.4813362 0.792097278 -0.336250476 0.220867006 1 3.914507138 3.048784926 387338 NOP2/Sun RNA methyltransferase 4 "GO:0001510,GO:0005515,GO:0005759,GO:0005762,GO:0008168,GO:0009383,GO:0019843,GO:0031167" RNA methylation|protein binding|mitochondrial matrix|mitochondrial large ribosomal subunit|methyltransferase activity|rRNA (cytosine-C5-)-methyltransferase activity|rRNA binding|rRNA methylation NSUN5 371.4597818 365.1852728 377.7342907 1.034363428 0.048743172 0.877867147 1 8.113766373 8.252144687 55695 NOP2/Sun RNA methyltransferase 5 "GO:0001510,GO:0003723,GO:0005654,GO:0005730,GO:0009383,GO:0014003,GO:0021987,GO:0022038,GO:0031641,GO:0045727,GO:0050890,GO:0070475" RNA methylation|RNA binding|nucleoplasm|nucleolus|rRNA (cytosine-C5-)-methyltransferase activity|oligodendrocyte development|cerebral cortex development|corpus callosum development|regulation of myelination|positive regulation of translation|cognition|rRNA base methylation NSUN6 174.5328656 191.4361544 157.6295768 0.82340547 -0.280325061 0.469208223 1 3.191688758 2.584077059 221078 NOP2/Sun RNA methyltransferase 6 "GO:0000049,GO:0001510,GO:0002946,GO:0005737,GO:0005829,GO:0006400,GO:0016428,GO:0030488" tRNA binding|RNA methylation|tRNA C5-cytosine methylation|cytoplasm|cytosol|tRNA modification|tRNA (cytosine-5-)-methyltransferase activity|tRNA methylation NT5C 727.2485742 760.5425482 693.9546002 0.912446781 -0.132187679 0.606797357 1 36.11099464 32.3979979 30833 "5', 3'-nucleotidase, cytosolic" "GO:0005634,GO:0005737,GO:0005829,GO:0006195,GO:0006204,GO:0008252,GO:0008253,GO:0009223,GO:0016311,GO:0019103,GO:0042802,GO:0046050,GO:0046055,GO:0046074,GO:0046079,GO:0046135,GO:0046872,GO:0050483,GO:0070062" nucleus|cytoplasm|cytosol|purine nucleotide catabolic process|IMP catabolic process|nucleotidase activity|5'-nucleotidase activity|pyrimidine deoxyribonucleotide catabolic process|dephosphorylation|pyrimidine nucleotide binding|identical protein binding|UMP catabolic process|dGMP catabolic process|dTMP catabolic process|dUMP catabolic process|pyrimidine nucleoside catabolic process|metal ion binding|IMP 5'-nucleotidase activity|extracellular exosome "hsa00230,hsa00240,hsa00760" Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism NT5C1A 2.962725795 2.080827765 3.844623824 1.847641543 0.88568489 0.829811711 1 0.012246356 0.022248245 84618 "5'-nucleotidase, cytosolic IA" "GO:0000166,GO:0000287,GO:0005515,GO:0005829,GO:0006195,GO:0008253,GO:0009116,GO:0009128,GO:0016311,GO:0046085,GO:0046135" nucleotide binding|magnesium ion binding|protein binding|cytosol|purine nucleotide catabolic process|5'-nucleotidase activity|nucleoside metabolic process|purine nucleoside monophosphate catabolic process|dephosphorylation|adenosine metabolic process|pyrimidine nucleoside catabolic process "hsa00230,hsa00240,hsa00760" Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism NT5C2 4869.048304 5584.941722 4153.154886 0.743634418 -0.427334551 0.074959016 1 50.15279741 36.67125919 22978 "5'-nucleotidase, cytosolic II" "GO:0000166,GO:0005515,GO:0005829,GO:0006195,GO:0008253,GO:0016311,GO:0017144,GO:0046040,GO:0046085,GO:0046872" nucleotide binding|protein binding|cytosol|purine nucleotide catabolic process|5'-nucleotidase activity|dephosphorylation|drug metabolic process|IMP metabolic process|adenosine metabolic process|metal ion binding "hsa00230,hsa00240,hsa00760" Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism NT5C3A 675.1486222 654.4203322 695.8769121 1.063348551 0.08861457 0.735263308 1 18.82760666 19.68529552 51251 "5'-nucleotidase, cytosolic IIIA" "GO:0000166,GO:0000215,GO:0000287,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0006213,GO:0008253,GO:0009117,GO:0016311,GO:0046135,GO:0051607" nucleotide binding|tRNA 2'-phosphotransferase activity|magnesium ion binding|protein binding|cytoplasm|endoplasmic reticulum|cytosol|pyrimidine nucleoside metabolic process|5'-nucleotidase activity|nucleotide metabolic process|dephosphorylation|pyrimidine nucleoside catabolic process|defense response to virus "hsa00230,hsa00240" Purine metabolism|Pyrimidine metabolism NT5C3B 1092.733215 1145.495685 1039.970744 0.907878361 -0.13942908 0.569324526 1 37.41309631 33.39815648 115024 "5'-nucleotidase, cytosolic IIIB" "GO:0000166,GO:0000287,GO:0005515,GO:0005737,GO:0005829,GO:0008253,GO:0009117,GO:0016311,GO:0043928" nucleotide binding|magnesium ion binding|protein binding|cytoplasm|cytosol|5'-nucleotidase activity|nucleotide metabolic process|dephosphorylation|exonucleolytic catabolism of deadenylated mRNA "hsa00230,hsa00240" Purine metabolism|Pyrimidine metabolism NT5DC1 722.6314928 689.7944042 755.4685814 1.095208336 0.131205332 0.60995143 1 4.824778449 5.195714689 221294 5'-nucleotidase domain containing 1 "GO:0008253,GO:0016311,GO:0046872" 5'-nucleotidase activity|dephosphorylation|metal ion binding NT5DC2 1417.903411 1594.954482 1240.852339 0.777986051 -0.362183806 0.13017397 1 30.13089887 23.04915863 64943 5'-nucleotidase domain containing 2 "GO:0008253,GO:0016311,GO:0046872" 5'-nucleotidase activity|dephosphorylation|metal ion binding NT5DC3 405.377643 372.46817 438.2871159 1.176710257 0.234759127 0.417708399 1 2.225474884 2.574918069 51559 5'-nucleotidase domain containing 3 "GO:0008253,GO:0016311,GO:0043235,GO:0046872" 5'-nucleotidase activity|dephosphorylation|receptor complex|metal ion binding NT5E 5860.96678 4676.660402 7045.273157 1.506475252 0.591176973 0.014770399 0.712638468 70.06871711 103.7904384 4907 5'-nucleotidase ecto "GO:0000166,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006195,GO:0006196,GO:0006259,GO:0007159,GO:0008253,GO:0009897,GO:0009986,GO:0016020,GO:0016311,GO:0019674,GO:0031225,GO:0046086,GO:0046135,GO:0046872,GO:0050728,GO:0070062" nucleotide binding|protein binding|nucleoplasm|cytosol|plasma membrane|purine nucleotide catabolic process|AMP catabolic process|DNA metabolic process|leukocyte cell-cell adhesion|5'-nucleotidase activity|external side of plasma membrane|cell surface|membrane|dephosphorylation|NAD metabolic process|anchored component of membrane|adenosine biosynthetic process|pyrimidine nucleoside catabolic process|metal ion binding|negative regulation of inflammatory response|extracellular exosome "hsa00230,hsa00240,hsa00760" Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism NT5M 50.36130809 47.8590386 52.86357758 1.104568314 0.143482648 0.841051362 1 0.91415495 0.99284985 56953 "5',3'-nucleotidase, mitochondrial" "GO:0000166,GO:0005739,GO:0005759,GO:0006260,GO:0008252,GO:0008253,GO:0009223,GO:0016311,GO:0046135,GO:0046872" nucleotide binding|mitochondrion|mitochondrial matrix|DNA replication|nucleotidase activity|5'-nucleotidase activity|pyrimidine deoxyribonucleotide catabolic process|dephosphorylation|pyrimidine nucleoside catabolic process|metal ion binding "hsa00230,hsa00240,hsa00760" Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism NTAN1 1044.879821 936.3724944 1153.387147 1.231761029 0.300722389 0.219606608 1 32.96337668 39.92356651 123803 N-terminal asparagine amidase "GO:0005515,GO:0005634,GO:0005737,GO:0006511,GO:0008418" protein binding|nucleus|cytoplasm|ubiquitin-dependent protein catabolic process|protein-N-terminal asparagine amidohydrolase activity NTAQ1 668.8665099 640.8949517 696.8380681 1.087289058 0.120735534 0.643403966 1 4.975037914 5.318786904 55093 N-terminal glutamine amidase 1 "GO:0005515,GO:0005634,GO:0005829,GO:0006464,GO:0008418,GO:0070773" protein binding|nucleus|cytosol|cellular protein modification process|protein-N-terminal asparagine amidohydrolase activity|protein-N-terminal glutamine amidohydrolase activity NTF4 7.887392465 5.202069413 10.57271552 2.032405698 1.023188414 0.464422034 1 0.118491201 0.236792359 4909 neurotrophin 4 "GO:0005163,GO:0005515,GO:0005576,GO:0005615,GO:0007169,GO:0007202,GO:0007402,GO:0007422,GO:0007613,GO:0007616,GO:0008021,GO:0008052,GO:0008083,GO:0008344,GO:0008544,GO:0021675,GO:0030424,GO:0030425,GO:0033138,GO:0038180,GO:0042490,GO:0043524,GO:0045664,GO:0048011,GO:0048812,GO:0050804,GO:0060384,GO:0061193" nerve growth factor receptor binding|protein binding|extracellular region|extracellular space|transmembrane receptor protein tyrosine kinase signaling pathway|activation of phospholipase C activity|ganglion mother cell fate determination|peripheral nervous system development|memory|long-term memory|synaptic vesicle|sensory organ boundary specification|growth factor activity|adult locomotory behavior|epidermis development|nerve development|axon|dendrite|positive regulation of peptidyl-serine phosphorylation|nerve growth factor signaling pathway|mechanoreceptor differentiation|negative regulation of neuron apoptotic process|regulation of neuron differentiation|neurotrophin TRK receptor signaling pathway|neuron projection morphogenesis|modulation of chemical synaptic transmission|innervation|taste bud development "hsa04010,hsa04014,hsa04151,hsa04722" MAPK signaling pathway|Ras signaling pathway|PI3K-Akt signaling pathway|Neurotrophin signaling pathway NTHL1 247.4863691 226.8102264 268.1625117 1.182321079 0.241621877 0.476813186 1 11.75188828 13.6619995 4913 nth like DNA glycosylase 1 "GO:0000703,GO:0003690,GO:0003906,GO:0004519,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006285,GO:0006296,GO:0008534,GO:0019104,GO:0045008,GO:0046872,GO:0051539,GO:0140078" "oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity|double-stranded DNA binding|DNA-(apurinic or apyrimidinic site) endonuclease activity|endonuclease activity|protein binding|nucleus|nucleoplasm|mitochondrion|base-excision repair, AP site formation|nucleotide-excision repair, DNA incision, 5'-to lesion|oxidized purine nucleobase lesion DNA N-glycosylase activity|DNA N-glycosylase activity|depyrimidination|metal ion binding|4 iron, 4 sulfur cluster binding|class I DNA-(apurinic or apyrimidinic site) endonuclease activity" hsa03410 Base excision repair NTM 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.026588177 0.032202249 50863 neurotrimin "GO:0005515,GO:0005576,GO:0005886,GO:0007155,GO:0008038,GO:0031225" protein binding|extracellular region|plasma membrane|cell adhesion|neuron recognition|anchored component of membrane NTMT1 1053.381155 1008.161052 1098.601258 1.089708093 0.123941723 0.614627924 1 36.90240222 39.53993883 28989 N-terminal Xaa-Pro-Lys N-methyltransferase 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006480,GO:0007051,GO:0007059,GO:0008168,GO:0008276,GO:0016571,GO:0018011,GO:0018012,GO:0018013,GO:0018016,GO:0035568,GO:0035570,GO:0035572,GO:0035573,GO:0042054,GO:0071885" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|N-terminal protein amino acid methylation|spindle organization|chromosome segregation|methyltransferase activity|protein methyltransferase activity|histone methylation|N-terminal peptidyl-alanine methylation|N-terminal peptidyl-alanine trimethylation|N-terminal peptidyl-glycine methylation|N-terminal peptidyl-proline dimethylation|N-terminal peptidyl-proline methylation|N-terminal peptidyl-serine methylation|N-terminal peptidyl-serine dimethylation|N-terminal peptidyl-serine trimethylation|histone methyltransferase activity|N-terminal protein N-methyltransferase activity NTN1 9.086322201 11.44455271 6.728091692 0.587885946 -0.766391806 0.566347083 1 0.28891899 0.16700918 9423 netrin 1 "GO:0001764,GO:0005515,GO:0005576,GO:0005604,GO:0005737,GO:0006915,GO:0006930,GO:0007097,GO:0007265,GO:0008045,GO:0008284,GO:0009887,GO:0009888,GO:0016358,GO:0030334,GO:0030517,GO:0032488,GO:0033564,GO:0042472,GO:0045773,GO:0051963,GO:0060603,GO:0061643,GO:0098609,GO:1902842,GO:2000147" "neuron migration|protein binding|extracellular region|basement membrane|cytoplasm|apoptotic process|substrate-dependent cell migration, cell extension|nuclear migration|Ras protein signal transduction|motor neuron axon guidance|positive regulation of cell population proliferation|animal organ morphogenesis|tissue development|dendrite development|regulation of cell migration|negative regulation of axon extension|Cdc42 protein signal transduction|anterior/posterior axon guidance|inner ear morphogenesis|positive regulation of axon extension|regulation of synapse assembly|mammary gland duct morphogenesis|chemorepulsion of axon|cell-cell adhesion|negative regulation of netrin-activated signaling pathway|positive regulation of cell motility" hsa04360 Axon guidance NTN4 982.929921 924.9279417 1040.9319 1.125419455 0.170462809 0.490200291 1 12.11330167 13.40442318 59277 netrin 4 "GO:0005515,GO:0005886,GO:0007411,GO:0009887,GO:0009888,GO:0016322,GO:0016477,GO:0034446,GO:0043237,GO:0043256,GO:0060668,GO:0070831" protein binding|plasma membrane|axon guidance|animal organ morphogenesis|tissue development|neuron remodeling|cell migration|substrate adhesion-dependent cell spreading|laminin-1 binding|laminin complex|regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling|basement membrane assembly hsa04360 Axon guidance NTN5 7.486072413 7.282897178 7.689247648 1.055795168 0.078329968 1 1 0.126769353 0.131602798 126147 netrin 5 "GO:0005102,GO:0005604,GO:0008045,GO:0009887,GO:0009888,GO:0016358,GO:0022008" signaling receptor binding|basement membrane|motor neuron axon guidance|animal organ morphogenesis|tissue development|dendrite development|neurogenesis NTNG1 1016.42634 984.231533 1048.621148 1.065421207 0.091423903 0.712396056 1 7.176749279 7.51831106 22854 netrin G1 "GO:0005515,GO:0005576,GO:0005886,GO:0007409,GO:0009887,GO:0009888,GO:0010975,GO:0016477,GO:0034446,GO:0043256,GO:0046658,GO:0050804,GO:0050839,GO:0070831,GO:0098632,GO:0098685,GO:0098978,GO:0099029,GO:0099560,GO:0150011,GO:2001222" protein binding|extracellular region|plasma membrane|axonogenesis|animal organ morphogenesis|tissue development|regulation of neuron projection development|cell migration|substrate adhesion-dependent cell spreading|laminin complex|anchored component of plasma membrane|modulation of chemical synaptic transmission|cell adhesion molecule binding|basement membrane assembly|cell-cell adhesion mediator activity|Schaffer collateral - CA1 synapse|glutamatergic synapse|anchored component of presynaptic active zone membrane|synaptic membrane adhesion|regulation of neuron projection arborization|regulation of neuron migration "hsa04360,hsa04514" Axon guidance|Cell adhesion molecules NTNG2 11.44958313 10.40413883 12.49502743 1.200967003 0.264196513 0.886277421 1 0.072100996 0.085141935 84628 netrin G2 "GO:0003674,GO:0005515,GO:0005576,GO:0005886,GO:0007409,GO:0009887,GO:0009888,GO:0010975,GO:0016477,GO:0030424,GO:0034446,GO:0043256,GO:0045171,GO:0046658,GO:0050804,GO:0070831,GO:0090543,GO:0098685,GO:0098698,GO:0098978,GO:0099029,GO:0099560,GO:0150011,GO:1905606,GO:2001222" molecular_function|protein binding|extracellular region|plasma membrane|axonogenesis|animal organ morphogenesis|tissue development|regulation of neuron projection development|cell migration|axon|substrate adhesion-dependent cell spreading|laminin complex|intercellular bridge|anchored component of plasma membrane|modulation of chemical synaptic transmission|basement membrane assembly|Flemming body|Schaffer collateral - CA1 synapse|postsynaptic specialization assembly|glutamatergic synapse|anchored component of presynaptic active zone membrane|synaptic membrane adhesion|regulation of neuron projection arborization|regulation of presynapse assembly|regulation of neuron migration "hsa04360,hsa04514" Axon guidance|Cell adhesion molecules NTPCR 579.0927772 605.5208797 552.6646747 0.912709525 -0.131772307 0.622439651 1 5.109983626 4.585886165 84284 "nucleoside-triphosphatase, cancer-related" "GO:0003723,GO:0005524,GO:0016020,GO:0017111" RNA binding|ATP binding|membrane|nucleoside-triphosphatase activity "hsa00230,hsa00730" Purine metabolism|Thiamine metabolism NTRK1 7.44644345 6.242483296 8.650403604 1.385731158 0.470647391 0.809847313 1 0.116039659 0.158109004 4914 neurotrophic receptor tyrosine kinase 1 "GO:0000139,GO:0000186,GO:0001934,GO:0004713,GO:0004714,GO:0005004,GO:0005030,GO:0005166,GO:0005515,GO:0005524,GO:0005769,GO:0005770,GO:0005886,GO:0005887,GO:0006468,GO:0007169,GO:0007275,GO:0007411,GO:0007568,GO:0007611,GO:0007623,GO:0008285,GO:0009314,GO:0009986,GO:0010008,GO:0010465,GO:0010623,GO:0010976,GO:0014068,GO:0018108,GO:0019900,GO:0021553,GO:0030183,GO:0030424,GO:0030425,GO:0031667,GO:0031901,GO:0031902,GO:0032991,GO:0033674,GO:0038083,GO:0038180,GO:0042490,GO:0042493,GO:0042802,GO:0042803,GO:0043025,GO:0043066,GO:0043068,GO:0043121,GO:0043235,GO:0043410,GO:0043524,GO:0043547,GO:0046579,GO:0046777,GO:0048011,GO:0048013,GO:0048015,GO:0048406,GO:0048485,GO:0048678,GO:0050965,GO:0050966,GO:0051092,GO:0051599,GO:0051602,GO:0051896,GO:0051965,GO:0051968,GO:0055038,GO:0060009,GO:0060385,GO:0061368,GO:0070374,GO:0071316,GO:1904646,GO:1990090" "Golgi membrane|activation of MAPKK activity|positive regulation of protein phosphorylation|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|GPI-linked ephrin receptor activity|neurotrophin receptor activity|neurotrophin p75 receptor binding|protein binding|ATP binding|early endosome|late endosome|plasma membrane|integral component of plasma membrane|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|aging|learning or memory|circadian rhythm|negative regulation of cell population proliferation|response to radiation|cell surface|endosome membrane|nerve growth factor receptor activity|programmed cell death involved in cell development|positive regulation of neuron projection development|positive regulation of phosphatidylinositol 3-kinase signaling|peptidyl-tyrosine phosphorylation|kinase binding|olfactory nerve development|B cell differentiation|axon|dendrite|response to nutrient levels|early endosome membrane|late endosome membrane|protein-containing complex|positive regulation of kinase activity|peptidyl-tyrosine autophosphorylation|nerve growth factor signaling pathway|mechanoreceptor differentiation|response to drug|identical protein binding|protein homodimerization activity|neuronal cell body|negative regulation of apoptotic process|positive regulation of programmed cell death|neurotrophin binding|receptor complex|positive regulation of MAPK cascade|negative regulation of neuron apoptotic process|positive regulation of GTPase activity|positive regulation of Ras protein signal transduction|protein autophosphorylation|neurotrophin TRK receptor signaling pathway|ephrin receptor signaling pathway|phosphatidylinositol-mediated signaling|nerve growth factor binding|sympathetic nervous system development|response to axon injury|detection of temperature stimulus involved in sensory perception of pain|detection of mechanical stimulus involved in sensory perception of pain|positive regulation of NF-kappaB transcription factor activity|response to hydrostatic pressure|response to electrical stimulus|regulation of protein kinase B signaling|positive regulation of synapse assembly|positive regulation of synaptic transmission, glutamatergic|recycling endosome membrane|Sertoli cell development|axonogenesis involved in innervation|behavioral response to formalin induced pain|positive regulation of ERK1 and ERK2 cascade|cellular response to nicotine|cellular response to amyloid-beta|cellular response to nerve growth factor stimulus" "hsa04010,hsa04014,hsa04020,hsa04151,hsa04210,hsa04722,hsa04750,hsa05200,hsa05202,hsa05216,hsa05230" MAPK signaling pathway|Ras signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Neurotrophin signaling pathway|Inflammatory mediator regulation of TRP channels|Pathways in cancer|Transcriptional misregulation in cancer|Thyroid cancer|Central carbon metabolism in cancer NTS 9.690817487 2.080827765 17.30080721 8.314386946 3.055609892 0.021734746 0.822216713 0.089628695 0.732737613 4922 neurotensin "GO:0005184,GO:0005515,GO:0005576,GO:0007165,GO:0007186,GO:0007218,GO:0030133,GO:0043231,GO:0043679,GO:0048018,GO:0071855" neuropeptide hormone activity|protein binding|extracellular region|signal transduction|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|transport vesicle|intracellular membrane-bounded organelle|axon terminus|receptor ligand activity|neuropeptide receptor binding hsa04080 Neuroactive ligand-receptor interaction NTSR1 47.99804716 48.89945248 47.09664184 0.963132294 -0.054194117 0.966747416 1 0.621498906 0.588569146 4923 neurotensin receptor 1 "GO:0001659,GO:0003085,GO:0003254,GO:0004930,GO:0005515,GO:0005739,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0007186,GO:0007218,GO:0007268,GO:0007612,GO:0008344,GO:0009898,GO:0009986,GO:0014049,GO:0014054,GO:0016492,GO:0032280,GO:0033993,GO:0042802,GO:0043065,GO:0043066,GO:0043195,GO:0043197,GO:0043198,GO:0043204,GO:0043576,GO:0044877,GO:0045121,GO:0047485,GO:0050965,GO:0051280,GO:0051281,GO:0051930,GO:0060732,GO:0070779,GO:0071545,GO:0090238,GO:0097151,GO:0098712,GO:0098900,GO:2001259" temperature homeostasis|negative regulation of systemic arterial blood pressure|regulation of membrane depolarization|G protein-coupled receptor activity|protein binding|mitochondrion|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|chemical synaptic transmission|learning|adult locomotory behavior|cytoplasmic side of plasma membrane|cell surface|positive regulation of glutamate secretion|positive regulation of gamma-aminobutyric acid secretion|G protein-coupled neurotensin receptor activity|symmetric synapse|response to lipid|identical protein binding|positive regulation of apoptotic process|negative regulation of apoptotic process|terminal bouton|dendritic spine|dendritic shaft|perikaryon|regulation of respiratory gaseous exchange|protein-containing complex binding|membrane raft|protein N-terminus binding|detection of temperature stimulus involved in sensory perception of pain|negative regulation of release of sequestered calcium ion into cytosol|positive regulation of release of sequestered calcium ion into cytosol|regulation of sensory perception of pain|positive regulation of inositol phosphate biosynthetic process|D-aspartate import across plasma membrane|inositol phosphate catabolic process|positive regulation of arachidonic acid secretion|positive regulation of inhibitory postsynaptic potential|L-glutamate import across plasma membrane|regulation of action potential|positive regulation of cation channel activity "hsa04020,hsa04080" Calcium signaling pathway|Neuroactive ligand-receptor interaction NUAK1 613.9768248 600.3188103 627.6348393 1.045502537 0.064196563 0.811817594 1 5.577630844 5.733846162 9891 NUAK family kinase 1 "GO:0001650,GO:0002039,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006468,GO:0006974,GO:0007155,GO:0015630,GO:0030155,GO:0035507,GO:0035556,GO:0042127,GO:0042149,GO:0046872,GO:0106310,GO:0106311,GO:1901796,GO:2000772" fibrillar center|p53 binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|protein phosphorylation|cellular response to DNA damage stimulus|cell adhesion|microtubule cytoskeleton|regulation of cell adhesion|regulation of myosin-light-chain-phosphatase activity|intracellular signal transduction|regulation of cell population proliferation|cellular response to glucose starvation|metal ion binding|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator|regulation of cellular senescence NUAK2 310.2332642 347.4982368 272.9682915 0.785524249 -0.348272283 0.264118682 1 5.291110477 4.086745606 81788 NUAK family kinase 2 "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0006915,GO:0030036,GO:0035556,GO:0042149,GO:0043066,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|apoptotic process|actin cytoskeleton organization|intracellular signal transduction|cellular response to glucose starvation|negative regulation of apoptotic process|protein serine kinase activity|protein threonine kinase activity NUB1 1470.787724 1444.094469 1497.480979 1.036968849 0.052372556 0.828974711 1 22.70063849 23.14594738 51667 negative regulator of ubiquitin like proteins 1 "GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006511,GO:0016567,GO:0032436,GO:0034341,GO:0034612,GO:0043687,GO:2000058" protein binding|nucleoplasm|nucleolus|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|response to interferon-gamma|response to tumor necrosis factor|post-translational protein modification|regulation of ubiquitin-dependent protein catabolic process NUBP1 229.5961578 198.7190516 260.4732641 1.310761409 0.390405103 0.259465679 1 5.549592126 7.152467457 4682 nucleotide binding protein 1 "GO:0000166,GO:0001558,GO:0005515,GO:0005524,GO:0005634,GO:0005814,GO:0005829,GO:0005886,GO:0005929,GO:0006879,GO:0010826,GO:0016226,GO:0030030,GO:0046872,GO:0051536,GO:0051539,GO:0051642,GO:0072697" "nucleotide binding|regulation of cell growth|protein binding|ATP binding|nucleus|centriole|cytosol|plasma membrane|cilium|cellular iron ion homeostasis|negative regulation of centrosome duplication|iron-sulfur cluster assembly|cell projection organization|metal ion binding|iron-sulfur cluster binding|4 iron, 4 sulfur cluster binding|centrosome localization|protein localization to cell cortex" NUBP2 592.7571662 585.7530159 599.7613165 1.023915029 0.034095997 0.903615058 1 11.06960407 11.14466925 10101 nucleotide binding protein 2 "GO:0000166,GO:0005515,GO:0005524,GO:0005634,GO:0005814,GO:0005829,GO:0005929,GO:0016226,GO:0030030,GO:0031616,GO:0046872,GO:0051536,GO:0051539" "nucleotide binding|protein binding|ATP binding|nucleus|centriole|cytosol|cilium|iron-sulfur cluster assembly|cell projection organization|spindle pole centrosome|metal ion binding|iron-sulfur cluster binding|4 iron, 4 sulfur cluster binding" NUBPL 250.3798978 201.8402932 298.9195023 1.480970412 0.566542818 0.090733016 1 0.774507153 1.127828315 80224 nucleotide binding protein like "GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0005886,GO:0016226,GO:0032981,GO:0046872,GO:0051539,GO:0070584" "protein binding|ATP binding|mitochondrion|mitochondrial matrix|plasma membrane|iron-sulfur cluster assembly|mitochondrial respiratory chain complex I assembly|metal ion binding|4 iron, 4 sulfur cluster binding|mitochondrion morphogenesis" NUCB1 3215.280985 3046.331848 3384.230121 1.110919719 0.151754564 0.522306513 1 62.74686678 68.54028386 4924 nucleobindin 1 "GO:0001965,GO:0003677,GO:0005085,GO:0005509,GO:0005515,GO:0005615,GO:0005634,GO:0005769,GO:0005788,GO:0005791,GO:0005793,GO:0005798,GO:0005801,GO:0005802,GO:0007264,GO:0016020,GO:0032580,GO:0043687,GO:0044267,GO:0050790,GO:0070062,GO:0072718,GO:0090498,GO:0098547,GO:1903533" G-protein alpha-subunit binding|DNA binding|guanyl-nucleotide exchange factor activity|calcium ion binding|protein binding|extracellular space|nucleus|early endosome|endoplasmic reticulum lumen|rough endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi-associated vesicle|cis-Golgi network|trans-Golgi network|small GTPase mediated signal transduction|membrane|Golgi cisterna membrane|post-translational protein modification|cellular protein metabolic process|regulation of catalytic activity|extracellular exosome|response to cisplatin|extrinsic component of Golgi membrane|lumenal side of Golgi membrane|regulation of protein targeting NUCB2 1192.689632 956.1403581 1429.238907 1.494800313 0.579952771 0.016809912 0.768814547 13.51362648 19.86215056 4925 nucleobindin 2 "GO:0001965,GO:0003677,GO:0005085,GO:0005509,GO:0005515,GO:0005615,GO:0005635,GO:0005783,GO:0005793,GO:0005794,GO:0005829,GO:0005886,GO:0007264,GO:0032099,GO:0050790,GO:0070062" G-protein alpha-subunit binding|DNA binding|guanyl-nucleotide exchange factor activity|calcium ion binding|protein binding|extracellular space|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|plasma membrane|small GTPase mediated signal transduction|negative regulation of appetite|regulation of catalytic activity|extracellular exosome NUCKS1 7333.835563 7714.66894 6953.002186 0.901270325 -0.149968205 0.540842969 1 63.99093913 56.70805273 64710 nuclear casein kinase and cyclin dependent kinase substrate 1 "GO:0000724,GO:0000785,GO:0001678,GO:0003682,GO:0003690,GO:0003697,GO:0003713,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006275,GO:0006325,GO:0006357,GO:0008134,GO:0019046,GO:0031297,GO:0035822,GO:0036297,GO:0043923,GO:0044829,GO:0045944,GO:0046626,GO:0046628,GO:0060382,GO:0071481,GO:1990968,GO:1990969" double-strand break repair via homologous recombination|chromatin|cellular glucose homeostasis|chromatin binding|double-stranded DNA binding|single-stranded DNA binding|transcription coactivator activity|RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|regulation of DNA replication|chromatin organization|regulation of transcription by RNA polymerase II|transcription factor binding|release from viral latency|replication fork processing|gene conversion|interstrand cross-link repair|positive regulation by host of viral transcription|positive regulation by host of viral genome replication|positive regulation of transcription by RNA polymerase II|regulation of insulin receptor signaling pathway|positive regulation of insulin receptor signaling pathway|regulation of DNA strand elongation|cellular response to X-ray|modulation by host of RNA binding by virus|modulation by host of viral RNA-binding transcription factor activity NUDC 3560.627238 3218.000139 3903.254337 1.212944117 0.278513084 0.240885702 1 77.99216757 93.01713559 10726 "nuclear distribution C, dynein complex regulator" "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005874,GO:0006457,GO:0007052,GO:0007080,GO:0030496,GO:0032502,GO:0045296,GO:0051082,GO:0051301,GO:0072686" protein binding|nucleoplasm|cytoplasm|cytosol|microtubule|protein folding|mitotic spindle organization|mitotic metaphase plate congression|midbody|developmental process|cadherin binding|unfolded protein binding|cell division|mitotic spindle NUDCD1 2594.85973 2238.970675 2950.748785 1.317904168 0.398245468 0.092251549 1 29.18655347 37.82141943 84955 NudC domain containing 1 "GO:0002376,GO:0005515,GO:0005654,GO:0005829" immune system process|protein binding|nucleoplasm|cytosol NUDCD2 873.3688172 799.0378619 947.6997726 1.186051147 0.246166226 0.323750273 1 4.827165737 5.629460895 134492 NudC domain containing 2 "GO:0000777,GO:0000922,GO:0005515,GO:0005737,GO:0005815,GO:0005829,GO:0006457,GO:0015630,GO:0032502,GO:0045171,GO:0051082,GO:0072686" condensed chromosome kinetochore|spindle pole|protein binding|cytoplasm|microtubule organizing center|cytosol|protein folding|microtubule cytoskeleton|developmental process|intercellular bridge|unfolded protein binding|mitotic spindle NUDCD3 3402.477454 3216.959725 3587.995184 1.115337303 0.157480079 0.507102047 1 19.16963243 21.02283064 23386 NudC domain containing 3 "GO:0005515,GO:0005737,GO:0005868,GO:0006457,GO:0032502,GO:0051082,GO:0060271,GO:1905793" protein binding|cytoplasm|cytoplasmic dynein complex|protein folding|developmental process|unfolded protein binding|cilium assembly|protein localization to pericentriolar material NUDT1 326.9446673 319.407062 334.4822727 1.047197487 0.066533541 0.837396077 1 20.71223311 21.32684907 4521 nudix hydrolase 1 "GO:0001669,GO:0003924,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0006195,GO:0006203,GO:0006281,GO:0006979,GO:0007568,GO:0008413,GO:0008584,GO:0008828,GO:0030515,GO:0031965,GO:0034656,GO:0035539,GO:0036219,GO:0042262,GO:0046061,GO:0046686,GO:0046872,GO:0047693,GO:0050072" "acrosomal vesicle|GTPase activity|protein binding|extracellular space|nucleus|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|plasma membrane|purine nucleotide catabolic process|dGTP catabolic process|DNA repair|response to oxidative stress|aging|8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity|male gonad development|dATP pyrophosphohydrolase activity|snoRNA binding|nuclear membrane|nucleobase-containing small molecule catabolic process|8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity|GTP diphosphatase activity|DNA protection|dATP catabolic process|response to cadmium ion|metal ion binding|ATP diphosphatase activity|m7G(5')pppN diphosphatase activity" NUDT12 569.2144901 472.3479027 666.0810775 1.410149328 0.495847945 0.062045614 1 7.227161534 10.02083809 83594 nudix hydrolase 12 "GO:0000210,GO:0000287,GO:0005515,GO:0005634,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0006402,GO:0006734,GO:0006742,GO:0008270,GO:0019677,GO:0034356,GO:0035529,GO:0110153,GO:0110155" NAD+ diphosphatase activity|magnesium ion binding|protein binding|nucleus|cytoplasm|peroxisome|peroxisomal matrix|cytosol|mRNA catabolic process|NADH metabolic process|NADP catabolic process|zinc ion binding|NAD catabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|NADH pyrophosphatase activity|RNA NAD-cap (NMN-forming) hydrolase activity|NAD-cap decapping "hsa00760,hsa04146" Nicotinate and nicotinamide metabolism|Peroxisome NUDT13 154.0019907 157.1024963 150.9014851 0.960528882 -0.0580991 0.901349678 1 3.823197211 3.61084052 25961 nudix hydrolase 13 "GO:0000210,GO:0005739,GO:0005759,GO:0006734,GO:0006742,GO:0015949,GO:0016462,GO:0035529,GO:0046872" NAD+ diphosphatase activity|mitochondrion|mitochondrial matrix|NADH metabolic process|NADP catabolic process|nucleobase-containing small molecule interconversion|pyrophosphatase activity|NADH pyrophosphatase activity|metal ion binding NUDT14 112.5735194 104.0413883 121.1056505 1.164014172 0.219108624 0.637648292 1 4.100810688 4.693525345 256281 nudix hydrolase 14 "GO:0005515,GO:0005829,GO:0006753,GO:0008768,GO:0018279,GO:0019693,GO:0042802,GO:0046872,GO:0047631" protein binding|cytosol|nucleoside phosphate metabolic process|UDP-sugar diphosphatase activity|protein N-linked glycosylation via asparagine|ribose phosphate metabolic process|identical protein binding|metal ion binding|ADP-ribose diphosphatase activity NUDT15 752.8934285 626.3291574 879.4576997 1.40414619 0.489693146 0.053537609 1 14.3829759 19.85785142 55270 nudix hydrolase 15 "GO:0000278,GO:0000302,GO:0005515,GO:0005829,GO:0006195,GO:0006203,GO:0008413,GO:0017110,GO:0034656,GO:0035529,GO:0035539,GO:0036218,GO:0042262,GO:0042738,GO:0046872,GO:0047429,GO:0061136,GO:1901292" "mitotic cell cycle|response to reactive oxygen species|protein binding|cytosol|purine nucleotide catabolic process|dGTP catabolic process|8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity|nucleoside-diphosphatase activity|nucleobase-containing small molecule catabolic process|NADH pyrophosphatase activity|8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity|dTTP diphosphatase activity|DNA protection|exogenous drug catabolic process|metal ion binding|nucleoside-triphosphate diphosphatase activity|regulation of proteasomal protein catabolic process|nucleoside phosphate catabolic process" NUDT16 567.7866187 636.7332962 498.8399412 0.783436243 -0.352112224 0.185301335 1 5.110736314 3.936935608 131870 nudix hydrolase 16 "GO:0000287,GO:0003729,GO:0005525,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006382,GO:0006402,GO:0006508,GO:0008235,GO:0008284,GO:0016077,GO:0016311,GO:0030145,GO:0030515,GO:0031404,GO:0034656,GO:0035863,GO:0035870,GO:0042802,GO:0042803,GO:0046709,GO:0050072,GO:0050897,GO:0090068,GO:0090502,GO:0098519,GO:1901639,GO:1901640,GO:1901641,GO:1990003,GO:1990174,GO:2000233,GO:2000781" "magnesium ion binding|mRNA binding|GTP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|adenosine to inosine editing|mRNA catabolic process|proteolysis|metalloexopeptidase activity|positive regulation of cell population proliferation|sno(s)RNA catabolic process|dephosphorylation|manganese ion binding|snoRNA binding|chloride ion binding|nucleobase-containing small molecule catabolic process|dITP catabolic process|dITP diphosphatase activity|identical protein binding|protein homodimerization activity|IDP catabolic process|m7G(5')pppN diphosphatase activity|cobalt ion binding|positive regulation of cell cycle process|RNA phosphodiester bond hydrolysis, endonucleolytic|nucleotide phosphatase activity, acting on free nucleotides|XDP catabolic process|XTP binding|ITP binding|inosine-diphosphatase activity|phosphodiesterase decapping endonuclease activity|negative regulation of rRNA processing|positive regulation of double-strand break repair" "hsa00230,hsa03018" Purine metabolism|RNA degradation NUDT16L1 169.4597439 159.183324 179.7361638 1.129114277 0.175191507 0.661001631 1 1.39313241 1.546683574 84309 nudix hydrolase 16 like 1 "GO:0003723,GO:0005515,GO:0005634,GO:0006402,GO:0016077,GO:0016311,GO:0030515,GO:0042803,GO:0050072,GO:0090502,GO:0098519,GO:1990174,GO:2001033" "RNA binding|protein binding|nucleus|mRNA catabolic process|sno(s)RNA catabolic process|dephosphorylation|snoRNA binding|protein homodimerization activity|m7G(5')pppN diphosphatase activity|RNA phosphodiester bond hydrolysis, endonucleolytic|nucleotide phosphatase activity, acting on free nucleotides|phosphodiesterase decapping endonuclease activity|negative regulation of double-strand break repair via nonhomologous end joining" hsa05205 Proteoglycans in cancer NUDT17 43.83136122 53.06110801 34.60161442 0.65210878 -0.61681545 0.332460591 1 1.296599731 0.831375369 200035 nudix hydrolase 17 "GO:0005777,GO:0005829,GO:0006734,GO:0006742,GO:0019677,GO:0035529,GO:0046872" peroxisome|cytosol|NADH metabolic process|NADP catabolic process|NAD catabolic process|NADH pyrophosphatase activity|metal ion binding NUDT18 108.2929769 92.59683556 123.9891183 1.339021119 0.421178715 0.359051565 1 2.863107142 3.769608131 79873 nudix hydrolase 18 "GO:0000287,GO:0005515,GO:0005829,GO:0034656,GO:0044715,GO:0044716,GO:0044717,GO:0046057,GO:0046067,GO:0046712" magnesium ion binding|protein binding|cytosol|nucleobase-containing small molecule catabolic process|8-oxo-dGDP phosphatase activity|8-oxo-GDP phosphatase activity|8-hydroxy-dADP phosphatase activity|dADP catabolic process|dGDP catabolic process|GDP catabolic process NUDT19 244.7117273 254.9014012 234.5220533 0.920050075 -0.120215711 0.730795001 1 3.592188882 3.249689056 390916 nudix hydrolase 19 "GO:0005575,GO:0005782,GO:0005829,GO:0006625,GO:0008150,GO:0009062,GO:0046872,GO:0047617" cellular_component|peroxisomal matrix|cytosol|protein targeting to peroxisome|biological_process|fatty acid catabolic process|metal ion binding|acyl-CoA hydrolase activity hsa04146 Peroxisome NUDT2 361.2833559 375.5894116 346.9773001 0.923820772 -0.11431511 0.707521512 1 18.92777771 17.19327179 318 nudix hydrolase 2 "GO:0004081,GO:0005515,GO:0005525,GO:0005759,GO:0006139,GO:0006167,GO:0006754,GO:0006915,GO:0008803,GO:0034599" bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity|protein binding|GTP binding|mitochondrial matrix|nucleobase-containing compound metabolic process|AMP biosynthetic process|ATP biosynthetic process|apoptotic process|bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity|cellular response to oxidative stress "hsa00230,hsa00240" Purine metabolism|Pyrimidine metabolism NUDT21 4969.013438 4777.580549 5160.446328 1.080138006 0.111215653 0.643414488 1 58.04022151 61.64239263 11051 nudix hydrolase 21 "GO:0000398,GO:0003682,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005847,GO:0005849,GO:0006369,GO:0006378,GO:0006397,GO:0010608,GO:0016604,GO:0016787,GO:0030154,GO:0031124,GO:0031439,GO:0034451,GO:0035925,GO:0042382,GO:0042802,GO:0042803,GO:0042826,GO:0051262,GO:0051290,GO:0098789,GO:0110104,GO:1900365,GO:1990120,GO:2000738,GO:2000975" "mRNA splicing, via spliceosome|chromatin binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|mRNA cleavage and polyadenylation specificity factor complex|mRNA cleavage factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA processing|posttranscriptional regulation of gene expression|nuclear body|hydrolase activity|cell differentiation|mRNA 3'-end processing|positive regulation of mRNA cleavage|centriolar satellite|mRNA 3'-UTR AU-rich region binding|paraspeckles|identical protein binding|protein homodimerization activity|histone deacetylase binding|protein tetramerization|protein heterotetramerization|pre-mRNA cleavage required for polyadenylation|mRNA alternative polyadenylation|positive regulation of mRNA polyadenylation|messenger ribonucleoprotein complex assembly|positive regulation of stem cell differentiation|positive regulation of pro-B cell differentiation" hsa03015 mRNA surveillance pathway NUDT22 737.8118433 684.5923348 791.0313518 1.155477956 0.208489737 0.413682822 1 25.76546874 29.27324658 84304 nudix hydrolase 22 "GO:0005515,GO:0005654,GO:0008768,GO:0046872,GO:0052751" protein binding|nucleoplasm|UDP-sugar diphosphatase activity|metal ion binding|GDP-mannose hydrolase activity NUDT3 869.2260546 942.6149777 795.8371316 0.844286533 -0.244195392 0.327759694 1 5.081376657 4.218348234 11165 nudix hydrolase 3 "GO:0000287,GO:0000298,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007267,GO:0008486,GO:0015961,GO:0034431,GO:0034432,GO:0043647,GO:0050072,GO:0052840,GO:0052842,GO:0071543,GO:0071544,GO:1901907,GO:1901909,GO:1901911" magnesium ion binding|endopolyphosphatase activity|protein binding|nucleus|cytoplasm|cytosol|cell-cell signaling|diphosphoinositol-polyphosphate diphosphatase activity|diadenosine polyphosphate catabolic process|bis(5'-adenosyl)-hexaphosphatase activity|bis(5'-adenosyl)-pentaphosphatase activity|inositol phosphate metabolic process|m7G(5')pppN diphosphatase activity|inositol diphosphate tetrakisphosphate diphosphatase activity|inositol diphosphate pentakisphosphate diphosphatase activity|diphosphoinositol polyphosphate metabolic process|diphosphoinositol polyphosphate catabolic process|diadenosine pentaphosphate catabolic process|diadenosine hexaphosphate catabolic process|adenosine 5'-(hexahydrogen pentaphosphate) catabolic process NUDT4 895.6031232 979.0294636 812.1767828 0.829573382 -0.269558491 0.278239399 1 7.975729368 6.505735406 11163 nudix hydrolase 4 "GO:0000298,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0008486,GO:0019722,GO:0019935,GO:0030515,GO:0034431,GO:0034432,GO:0035556,GO:0043647,GO:0046872,GO:0050072,GO:0052840,GO:0052842,GO:0071543,GO:1901907,GO:1901909,GO:1901911" endopolyphosphatase activity|protein binding|nucleus|cytoplasm|cytosol|diphosphoinositol-polyphosphate diphosphatase activity|calcium-mediated signaling|cyclic-nucleotide-mediated signaling|snoRNA binding|bis(5'-adenosyl)-hexaphosphatase activity|bis(5'-adenosyl)-pentaphosphatase activity|intracellular signal transduction|inositol phosphate metabolic process|metal ion binding|m7G(5')pppN diphosphatase activity|inositol diphosphate tetrakisphosphate diphosphatase activity|inositol diphosphate pentakisphosphate diphosphatase activity|diphosphoinositol polyphosphate metabolic process|diadenosine pentaphosphate catabolic process|diadenosine hexaphosphate catabolic process|adenosine 5'-(hexahydrogen pentaphosphate) catabolic process NUDT4B 4.964295633 4.161655531 5.766935736 1.385731158 0.470647391 0.897151737 1 0.060982951 0.083091882 440672 nudix hydrolase 4B "GO:0000298,GO:0003723,GO:0005634,GO:0005737,GO:0005829,GO:0008486,GO:0034431,GO:0034432,GO:0046872,GO:0050072,GO:0052840,GO:0052842,GO:0071543,GO:1901907,GO:1901909,GO:1901911" endopolyphosphatase activity|RNA binding|nucleus|cytoplasm|cytosol|diphosphoinositol-polyphosphate diphosphatase activity|bis(5'-adenosyl)-hexaphosphatase activity|bis(5'-adenosyl)-pentaphosphatase activity|metal ion binding|m7G(5')pppN diphosphatase activity|inositol diphosphate tetrakisphosphate diphosphatase activity|inositol diphosphate pentakisphosphate diphosphatase activity|diphosphoinositol polyphosphate metabolic process|diadenosine pentaphosphate catabolic process|diadenosine hexaphosphate catabolic process|adenosine 5'-(hexahydrogen pentaphosphate) catabolic process NUDT5 1369.797766 1316.123562 1423.471971 1.081564081 0.113119146 0.638901772 1 21.34926916 22.70421273 11164 nudix hydrolase 5 "GO:0000287,GO:0005515,GO:0005634,GO:0005829,GO:0006338,GO:0006753,GO:0009117,GO:0009191,GO:0016779,GO:0019144,GO:0019303,GO:0019693,GO:0030515,GO:0034656,GO:0042802,GO:0042803,GO:0044715,GO:0044716,GO:0047631,GO:0050072,GO:0070062,GO:1990966" magnesium ion binding|protein binding|nucleus|cytosol|chromatin remodeling|nucleoside phosphate metabolic process|nucleotide metabolic process|ribonucleoside diphosphate catabolic process|nucleotidyltransferase activity|ADP-sugar diphosphatase activity|D-ribose catabolic process|ribose phosphate metabolic process|snoRNA binding|nucleobase-containing small molecule catabolic process|identical protein binding|protein homodimerization activity|8-oxo-dGDP phosphatase activity|8-oxo-GDP phosphatase activity|ADP-ribose diphosphatase activity|m7G(5')pppN diphosphatase activity|extracellular exosome|ATP generation from poly-ADP-D-ribose hsa00230 Purine metabolism NUDT6 83.59038566 74.90979955 92.27097178 1.231761029 0.300722389 0.557960366 1 2.86580525 3.470917668 11162 nudix hydrolase 6 "GO:0005634,GO:0005737,GO:0005739,GO:0008285,GO:0035529,GO:0045786,GO:0047631,GO:0051287" nucleus|cytoplasm|mitochondrion|negative regulation of cell population proliferation|NADH pyrophosphatase activity|negative regulation of cell cycle|ADP-ribose diphosphatase activity|NAD binding NUDT7 156.0431895 160.2237379 151.862641 0.947816116 -0.077320902 0.861882713 1 6.557397557 6.111204013 283927 nudix hydrolase 7 "GO:0000287,GO:0003674,GO:0003986,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0008150,GO:0009062,GO:0009132,GO:0010945,GO:0015938,GO:0016289,GO:0030145,GO:0030515,GO:0036114,GO:0044580,GO:0046356,GO:0050072,GO:0050873,GO:1902859" magnesium ion binding|molecular_function|acetyl-CoA hydrolase activity|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|biological_process|fatty acid catabolic process|nucleoside diphosphate metabolic process|CoA pyrophosphatase activity|coenzyme A catabolic process|CoA hydrolase activity|manganese ion binding|snoRNA binding|medium-chain fatty-acyl-CoA catabolic process|butyryl-CoA catabolic process|acetyl-CoA catabolic process|m7G(5')pppN diphosphatase activity|brown fat cell differentiation|propionyl-CoA catabolic process hsa04146 Peroxisome NUDT8 35.70619497 41.61655531 29.79583464 0.715961098 -0.482046894 0.492813047 1 2.019090062 1.421399948 254552 nudix hydrolase 8 "GO:0016787,GO:0046872" hydrolase activity|metal ion binding NUDT9 344.9587959 338.1345119 351.7830799 1.040364315 0.05708882 0.859105835 1 3.570561423 3.652524473 53343 nudix hydrolase 9 "GO:0005515,GO:0005739,GO:0005759,GO:0016604,GO:0019144,GO:0030054,GO:0031965,GO:0034656,GO:0046032,GO:0046709,GO:0047631,GO:0070062" protein binding|mitochondrion|mitochondrial matrix|nuclear body|ADP-sugar diphosphatase activity|cell junction|nuclear membrane|nucleobase-containing small molecule catabolic process|ADP catabolic process|IDP catabolic process|ADP-ribose diphosphatase activity|extracellular exosome hsa00230 Purine metabolism NUF2 1317.093319 1219.36507 1414.821567 1.160293666 0.214489992 0.37293482 1 30.33812248 34.61208807 83540 NUF2 component of NDC80 kinetochore complex "GO:0000775,GO:0000776,GO:0000778,GO:0003674,GO:0005515,GO:0005654,GO:0005829,GO:0007052,GO:0007059,GO:0016020,GO:0031262,GO:0044877,GO:0045132,GO:0051301,GO:0051315,GO:0051383" "chromosome, centromeric region|kinetochore|condensed nuclear chromosome kinetochore|molecular_function|protein binding|nucleoplasm|cytosol|mitotic spindle organization|chromosome segregation|membrane|Ndc80 complex|protein-containing complex binding|meiotic chromosome segregation|cell division|attachment of mitotic spindle microtubules to kinetochore|kinetochore organization" NUFIP1 335.1440611 345.417409 324.8707131 0.940516328 -0.088475105 0.77931013 1 5.297210422 4.898743982 26747 nuclear FMR1 interacting protein 1 "GO:0000492,GO:0001650,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005726,GO:0005730,GO:0006396,GO:0008023,GO:0016363,GO:0022626,GO:0030515,GO:0030674,GO:0032991,GO:0042802,GO:0045944,GO:0046872,GO:0048786,GO:0051117,GO:0070761" box C/D snoRNP assembly|fibrillar center|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|perichromatin fibrils|nucleolus|RNA processing|transcription elongation factor complex|nuclear matrix|cytosolic ribosome|snoRNA binding|protein-macromolecule adaptor activity|protein-containing complex|identical protein binding|positive regulation of transcription by RNA polymerase II|metal ion binding|presynaptic active zone|ATPase binding|pre-snoRNP complex NUFIP2 3884.938231 4010.795518 3759.080944 0.937240736 -0.093508434 0.694925296 1 17.07064242 15.73157482 57532 nuclear FMR1 interacting protein 2 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0010494,GO:0016020,GO:0016604,GO:0042788" RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoplasmic stress granule|membrane|nuclear body|polysomal ribosome NUMA1 4624.171686 4745.327719 4503.015654 0.948936706 -0.075616232 0.752577675 1 29.22333473 27.26705268 4926 nuclear mitotic apparatus protein 1 "GO:0000132,GO:0000139,GO:0000922,GO:0001578,GO:0005198,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005794,GO:0005813,GO:0005819,GO:0005829,GO:0005876,GO:0005938,GO:0006622,GO:0006997,GO:0007059,GO:0008017,GO:0008022,GO:0015631,GO:0016328,GO:0016363,GO:0019897,GO:0019904,GO:0030425,GO:0030513,GO:0030953,GO:0031023,GO:0031116,GO:0031616,GO:0032388,GO:0032991,GO:0034067,GO:0034499,GO:0035091,GO:0035371,GO:0036449,GO:0043025,GO:0044877,GO:0045618,GO:0051010,GO:0051011,GO:0051301,GO:0051321,GO:0051798,GO:0051984,GO:0055028,GO:0055048,GO:0060236,GO:0061673,GO:0070062,GO:0070840,GO:0070861,GO:0071955,GO:0072686,GO:0090161,GO:0090235,GO:0097427,GO:0097431,GO:0097575,GO:0097718,GO:0099738,GO:1902365,GO:1902846,GO:1904778,GO:1905720,GO:1905820,GO:1905832,GO:1990023" establishment of mitotic spindle orientation|Golgi membrane|spindle pole|microtubule bundle formation|structural molecule activity|protein binding|nucleus|nucleoplasm|chromosome|Golgi apparatus|centrosome|spindle|cytosol|spindle microtubule|cell cortex|protein targeting to lysosome|nucleus organization|chromosome segregation|microtubule binding|protein C-terminus binding|tubulin binding|lateral plasma membrane|nuclear matrix|extrinsic component of plasma membrane|protein domain specific binding|dendrite|positive regulation of BMP signaling pathway|astral microtubule organization|microtubule organizing center organization|positive regulation of microtubule polymerization|spindle pole centrosome|positive regulation of intracellular transport|protein-containing complex|protein localization to Golgi apparatus|late endosome to Golgi transport|phosphatidylinositol binding|microtubule plus-end|microtubule minus-end|neuronal cell body|protein-containing complex binding|positive regulation of keratinocyte differentiation|microtubule plus-end binding|microtubule minus-end binding|cell division|meiotic cell cycle|positive regulation of hair follicle development|positive regulation of chromosome segregation|cortical microtubule|anastral spindle assembly|regulation of mitotic spindle organization|mitotic spindle astral microtubule|extracellular exosome|dynein complex binding|regulation of protein exit from endoplasmic reticulum|recycling endosome to Golgi transport|mitotic spindle|Golgi ribbon formation|regulation of metaphase plate congression|microtubule bundle|mitotic spindle pole|lateral cell cortex|disordered domain specific binding|cell cortex region|positive regulation of protein localization to spindle pole body|positive regulation of mitotic spindle elongation|positive regulation of protein localization to cell cortex|cytoplasmic microtubule bundle|positive regulation of chromosome separation|positive regulation of spindle assembly|mitotic spindle midzone NUMB 2929.456589 2948.532943 2910.380235 0.987060443 -0.018789663 0.938218826 1 42.4259326 41.17620564 8650 NUMB endocytic adaptor protein "GO:0005515,GO:0005634,GO:0005737,GO:0005769,GO:0005886,GO:0005905,GO:0005925,GO:0007409,GO:0008013,GO:0010008,GO:0016323,GO:0019897,GO:0021670,GO:0021849,GO:0030136,GO:0030335,GO:0034332,GO:0045177,GO:0045294,GO:0045296,GO:0050769,GO:0098978,GO:0099149,GO:1903077" protein binding|nucleus|cytoplasm|early endosome|plasma membrane|clathrin-coated pit|focal adhesion|axonogenesis|beta-catenin binding|endosome membrane|basolateral plasma membrane|extrinsic component of plasma membrane|lateral ventricle development|neuroblast division in subventricular zone|clathrin-coated vesicle|positive regulation of cell migration|adherens junction organization|apical part of cell|alpha-catenin binding|cadherin binding|positive regulation of neurogenesis|glutamatergic synapse|regulation of postsynaptic neurotransmitter receptor internalization|negative regulation of protein localization to plasma membrane hsa04330 Notch signaling pathway NUMBL 475.3432685 468.1862472 482.5002899 1.030573394 0.043447253 0.882741461 1 6.778686794 6.869034109 9253 NUMB like endocytic adaptor protein "GO:0005515,GO:0005737,GO:0007399,GO:0007409,GO:0019221,GO:0019538,GO:0021670,GO:0021849,GO:0034332,GO:0050769" protein binding|cytoplasm|nervous system development|axonogenesis|cytokine-mediated signaling pathway|protein metabolic process|lateral ventricle development|neuroblast division in subventricular zone|adherens junction organization|positive regulation of neurogenesis hsa04330 Notch signaling pathway NUP107 2367.605483 2290.99137 2444.219596 1.066882935 0.093401883 0.693823868 1 19.56882182 20.52828299 57122 nucleoporin 107 "GO:0000776,GO:0000777,GO:0000973,GO:0005515,GO:0005635,GO:0005643,GO:0005829,GO:0006110,GO:0006355,GO:0006406,GO:0006409,GO:0006606,GO:0008585,GO:0016020,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031080,GO:0031965,GO:0034399,GO:0043657,GO:0051292,GO:0060964,GO:0072006,GO:0075733,GO:1900034" "kinetochore|condensed chromosome kinetochore|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|protein binding|nuclear envelope|nuclear pore|cytosol|regulation of glycolytic process|regulation of transcription, DNA-templated|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|female gonad development|membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear pore outer ring|nuclear membrane|nuclear periphery|host cell|nuclear pore complex assembly|regulation of gene silencing by miRNA|nephron development|intracellular transport of virus|regulation of cellular response to heat" "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP133 1502.975774 1569.984549 1435.966998 0.914637663 -0.128727768 0.590860952 1 16.0881701 14.46861327 55746 nucleoporin 133 "GO:0000777,GO:0000940,GO:0000972,GO:0005515,GO:0005635,GO:0005643,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006606,GO:0006999,GO:0016020,GO:0016032,GO:0016925,GO:0016973,GO:0017056,GO:0019083,GO:0021915,GO:0022008,GO:0031080,GO:0031965,GO:0043657,GO:0048339,GO:0060964,GO:0061053,GO:0072006,GO:0075733,GO:1900034" condensed chromosome kinetochore|condensed chromosome outer kinetochore|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|protein binding|nuclear envelope|nuclear pore|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|nuclear pore organization|membrane|viral process|protein sumoylation|poly(A)+ mRNA export from nucleus|structural constituent of nuclear pore|viral transcription|neural tube development|neurogenesis|nuclear pore outer ring|nuclear membrane|host cell|paraxial mesoderm development|regulation of gene silencing by miRNA|somite development|nephron development|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP153 1949.087459 2128.686804 1769.488115 0.831258084 -0.266631628 0.260047976 1 19.97610381 16.32743062 9972 nucleoporin 153 "GO:0003677,GO:0005515,GO:0005643,GO:0005654,GO:0005730,GO:0005829,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0008139,GO:0016020,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0034399,GO:0042405,GO:0042802,GO:0043495,GO:0043657,GO:0044615,GO:0046718,GO:0046832,GO:0046872,GO:0051292,GO:0060964,GO:0075732,GO:0075733,GO:1900034" DNA binding|protein binding|nuclear pore|nucleoplasm|nucleolus|cytosol|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|nuclear localization sequence binding|membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|nuclear periphery|nuclear inclusion body|identical protein binding|protein-membrane adaptor activity|host cell|nuclear pore nuclear basket|viral entry into host cell|negative regulation of RNA export from nucleus|metal ion binding|nuclear pore complex assembly|regulation of gene silencing by miRNA|viral penetration into host nucleus|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP155 2271.916359 2226.485709 2317.34701 1.04080929 0.057705744 0.808671038 1 14.19635008 14.52844184 9631 nucleoporin 155 "GO:0000972,GO:0005515,GO:0005635,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0006998,GO:0016020,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0036228,GO:0043657,GO:0044611,GO:0060964,GO:0075733,GO:0086014,GO:1900034" transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|protein binding|nuclear envelope|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|nuclear envelope organization|membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|protein localization to nuclear inner membrane|host cell|nuclear pore inner ring|regulation of gene silencing by miRNA|intracellular transport of virus|atrial cardiac muscle cell action potential|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP160 1740.973886 1888.351197 1593.596575 0.843909003 -0.244840651 0.302323006 1 16.49121793 13.68420366 23279 nucleoporin 160 "GO:0000776,GO:0005515,GO:0005635,GO:0005643,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031080,GO:0043657,GO:0060964,GO:0072006,GO:0075733,GO:1900034" kinetochore|protein binding|nuclear envelope|nuclear pore|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear pore outer ring|host cell|regulation of gene silencing by miRNA|nephron development|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP188 2320.447247 2642.651262 1998.243233 0.756150939 -0.403253849 0.088084548 1 24.79055034 18.43171906 23511 nucleoporin 188 "GO:0005635,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0016020,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0043657,GO:0044611,GO:0060964,GO:0075733,GO:1900034" nuclear envelope|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|host cell|nuclear pore inner ring|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP205 3689.671315 3792.308602 3587.034028 0.945870815 -0.080284938 0.73619524 1 32.30979249 30.04949464 23165 nucleoporin 205 "GO:0005515,GO:0005635,GO:0005643,GO:0006110,GO:0006406,GO:0006409,GO:0006913,GO:0006999,GO:0016020,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0034399,GO:0043657,GO:0044611,GO:0051292,GO:0060964,GO:0075733,GO:1900034" protein binding|nuclear envelope|nuclear pore|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|nucleocytoplasmic transport|nuclear pore organization|membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|nuclear periphery|host cell|nuclear pore inner ring|nuclear pore complex assembly|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP210 347.1289424 319.407062 374.8508228 1.173583391 0.230920358 0.44622967 1 1.601932887 1.848542545 23225 nucleoporin 210 "GO:0005635,GO:0005643,GO:0005789,GO:0006110,GO:0006406,GO:0006409,GO:0016020,GO:0016021,GO:0016032,GO:0016925,GO:0019083,GO:0031965,GO:0043657,GO:0060964,GO:0065003,GO:0075733,GO:1900034" nuclear envelope|nuclear pore|endoplasmic reticulum membrane|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|membrane|integral component of membrane|viral process|protein sumoylation|viral transcription|nuclear membrane|host cell|regulation of gene silencing by miRNA|protein-containing complex assembly|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP214 1548.014897 1806.1585 1289.871293 0.714151772 -0.485697386 0.041617311 1 12.18139259 8.553791041 8021 nucleoporin 214 "GO:0000278,GO:0005049,GO:0005515,GO:0005643,GO:0005654,GO:0005829,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0006611,GO:0008139,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0043488,GO:0043657,GO:0046822,GO:0051726,GO:0060964,GO:0075733,GO:1900034,GO:1990876" mitotic cell cycle|nuclear export signal receptor activity|protein binding|nuclear pore|nucleoplasm|cytosol|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|protein export from nucleus|nuclear localization sequence binding|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|regulation of mRNA stability|host cell|regulation of nucleocytoplasmic transport|regulation of cell cycle|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat|cytoplasmic side of nuclear pore "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP35 416.9259913 435.9334168 397.9185658 0.912796658 -0.131634586 0.650528544 1 9.045476378 8.118516235 129401 nucleoporin 35 "GO:0003697,GO:0005515,GO:0005543,GO:0005635,GO:0005652,GO:0005654,GO:0005886,GO:0006110,GO:0006355,GO:0006406,GO:0006409,GO:0006607,GO:0006999,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0042802,GO:0043657,GO:0044613,GO:0044615,GO:0060964,GO:0075733,GO:1900034,GO:1990830" "single-stranded DNA binding|protein binding|phospholipid binding|nuclear envelope|nuclear lamina|nucleoplasm|plasma membrane|regulation of glycolytic process|regulation of transcription, DNA-templated|mRNA export from nucleus|tRNA export from nucleus|NLS-bearing protein import into nucleus|nuclear pore organization|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|identical protein binding|host cell|nuclear pore central transport channel|nuclear pore nuclear basket|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat|cellular response to leukemia inhibitory factor" "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP37 963.5187179 894.7559391 1032.281497 1.153701754 0.206270318 0.404034523 1 20.21654529 22.9335705 79023 nucleoporin 37 "GO:0000776,GO:0000777,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0007049,GO:0007059,GO:0016032,GO:0016925,GO:0019083,GO:0031080,GO:0043657,GO:0051301,GO:0060964,GO:0075733,GO:1900034" kinetochore|condensed chromosome kinetochore|protein binding|nucleus|nuclear envelope|nucleoplasm|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|cell cycle|chromosome segregation|viral process|protein sumoylation|viral transcription|nuclear pore outer ring|host cell|cell division|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP42 514.8689353 572.2276355 457.5102351 0.799524886 -0.322785155 0.234706569 1 12.88554312 10.12991715 11097 nucleoporin 42 "GO:0003723,GO:0005049,GO:0005515,GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006611,GO:0016032,GO:0016925,GO:0019083,GO:0031965,GO:0043657,GO:0046872,GO:0060964,GO:0075733,GO:1900034" RNA binding|nuclear export signal receptor activity|protein binding|nucleus|nuclear envelope|nuclear pore|nucleoplasm|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein export from nucleus|viral process|protein sumoylation|viral transcription|nuclear membrane|host cell|metal ion binding|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport NUP43 1195.631008 1210.001346 1181.26067 0.976247402 -0.034681291 0.889528631 1 9.684395309 9.296159753 348995 nucleoporin 43 "GO:0000776,GO:0000777,GO:0005515,GO:0005635,GO:0005654,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0007049,GO:0007059,GO:0016032,GO:0016607,GO:0016925,GO:0019083,GO:0031080,GO:0043657,GO:0051301,GO:0060964,GO:0075733,GO:1900034" kinetochore|condensed chromosome kinetochore|protein binding|nuclear envelope|nucleoplasm|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|cell cycle|chromosome segregation|viral process|nuclear speck|protein sumoylation|viral transcription|nuclear pore outer ring|host cell|cell division|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP50 2853.040275 2860.097763 2845.982786 0.995064862 -0.007137526 0.977579192 1 24.82324947 24.28740982 10762 nucleoporin 50 "GO:0005515,GO:0005643,GO:0005654,GO:0006110,GO:0006406,GO:0006409,GO:0006606,GO:0016032,GO:0016925,GO:0019083,GO:0031965,GO:0043657,GO:0060964,GO:0075733,GO:1900034" protein binding|nuclear pore|nucleoplasm|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|viral process|protein sumoylation|viral transcription|nuclear membrane|host cell|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP54 1134.736613 1163.182721 1106.290505 0.951089185 -0.072347465 0.768945094 1 12.55601213 11.74205603 53371 nucleoporin 54 "GO:0005515,GO:0005635,GO:0006110,GO:0006406,GO:0006409,GO:0006605,GO:0006607,GO:0006999,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0036228,GO:0042306,GO:0042802,GO:0043657,GO:0044613,GO:0044877,GO:0060964,GO:0075733,GO:1900034" protein binding|nuclear envelope|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein targeting|NLS-bearing protein import into nucleus|nuclear pore organization|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|protein localization to nuclear inner membrane|regulation of protein import into nucleus|identical protein binding|host cell|nuclear pore central transport channel|protein-containing complex binding|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP58 2467.312223 2423.123933 2511.500513 1.036472167 0.051681375 0.828397615 1 25.53162306 26.01999727 9818 nucleoporin 58 "GO:0005515,GO:0005635,GO:0005643,GO:0006110,GO:0006406,GO:0006409,GO:0008139,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0042306,GO:0042802,GO:0043657,GO:0044877,GO:0060964,GO:0075733,GO:1900034" protein binding|nuclear envelope|nuclear pore|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|nuclear localization sequence binding|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|regulation of protein import into nucleus|identical protein binding|host cell|protein-containing complex binding|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP62 1323.483028 1462.821919 1184.144138 0.809493023 -0.304909448 0.20460666 1 23.00180238 18.30822143 23636 nucleoporin 62 "GO:0000922,GO:0003682,GO:0005515,GO:0005543,GO:0005635,GO:0005642,GO:0005643,GO:0005654,GO:0005737,GO:0005813,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0007080,GO:0007098,GO:0007100,GO:0007166,GO:0007283,GO:0007569,GO:0008219,GO:0008285,GO:0009966,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0019894,GO:0030159,GO:0030544,GO:0031965,GO:0042059,GO:0042169,GO:0042306,GO:0043066,GO:0043069,GO:0043123,GO:0043130,GO:0043407,GO:0043657,GO:0044613,GO:0044877,GO:0045742,GO:0045840,GO:0045893,GO:0046578,GO:0046580,GO:0046601,GO:0051425,GO:0051879,GO:0060236,GO:0060964,GO:0072686,GO:0075733,GO:0090543,GO:0098534,GO:1900034,GO:1903438,GO:1904781,GO:1990904" "spindle pole|chromatin binding|protein binding|phospholipid binding|nuclear envelope|annulate lamellae|nuclear pore|nucleoplasm|cytoplasm|centrosome|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|mitotic metaphase plate congression|centrosome cycle|mitotic centrosome separation|cell surface receptor signaling pathway|spermatogenesis|cell aging|cell death|negative regulation of cell population proliferation|regulation of signal transduction|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|kinesin binding|signaling receptor complex adaptor activity|Hsp70 protein binding|nuclear membrane|negative regulation of epidermal growth factor receptor signaling pathway|SH2 domain binding|regulation of protein import into nucleus|negative regulation of apoptotic process|negative regulation of programmed cell death|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|negative regulation of MAP kinase activity|host cell|nuclear pore central transport channel|protein-containing complex binding|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of mitotic nuclear division|positive regulation of transcription, DNA-templated|regulation of Ras protein signal transduction|negative regulation of Ras protein signal transduction|positive regulation of centriole replication|PTB domain binding|Hsp90 protein binding|regulation of mitotic spindle organization|regulation of gene silencing by miRNA|mitotic spindle|intracellular transport of virus|Flemming body|centriole assembly|regulation of cellular response to heat|positive regulation of mitotic cytokinetic process|positive regulation of protein localization to centrosome|ribonucleoprotein complex" "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP62CL 15.49235177 15.60620824 15.3784953 0.985408823 -0.021205706 1 1 0.474572451 0.459822426 54830 nucleoporin 62 C-terminal like "GO:0005515,GO:0005543,GO:0006405,GO:0006606,GO:0017056,GO:0044613" protein binding|phospholipid binding|RNA export from nucleus|protein import into nucleus|structural constituent of nuclear pore|nuclear pore central transport channel NUP85 2040.378382 1976.786377 2103.970388 1.064338773 0.089957426 0.705087766 1 33.02988596 34.56671719 79902 nucleoporin 85 "GO:0000776,GO:0000777,GO:0005515,GO:0005635,GO:0005654,GO:0005819,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006606,GO:0016020,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0030032,GO:0031080,GO:0031965,GO:0043657,GO:0045893,GO:0048246,GO:0060964,GO:0072006,GO:0075733,GO:1900034" "kinetochore|condensed chromosome kinetochore|protein binding|nuclear envelope|nucleoplasm|spindle|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|lamellipodium assembly|nuclear pore outer ring|nuclear membrane|host cell|positive regulation of transcription, DNA-templated|macrophage chemotaxis|regulation of gene silencing by miRNA|nephron development|intracellular transport of virus|regulation of cellular response to heat" "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP88 1544.785443 1670.904696 1418.666191 0.849040759 -0.236094281 0.322082791 1 23.55338421 19.66314739 4927 nucleoporin 88 "GO:0000055,GO:0000056,GO:0000278,GO:0005215,GO:0005515,GO:0005643,GO:0005654,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006606,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0043657,GO:0060964,GO:0075733,GO:1900034" ribosomal large subunit export from nucleus|ribosomal small subunit export from nucleus|mitotic cell cycle|transporter activity|protein binding|nuclear pore|nucleoplasm|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|host cell|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP93 2232.766861 2182.788326 2282.745395 1.045793295 0.064597726 0.786139112 1 31.11415629 31.99448033 9688 nucleoporin 93 "GO:0005515,GO:0005635,GO:0005643,GO:0006110,GO:0006406,GO:0006409,GO:0006606,GO:0006998,GO:0016020,GO:0016032,GO:0016925,GO:0016973,GO:0017056,GO:0019083,GO:0031965,GO:0034399,GO:0043657,GO:0051292,GO:0060391,GO:0060395,GO:0060964,GO:0075733,GO:1900034" protein binding|nuclear envelope|nuclear pore|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|nuclear envelope organization|membrane|viral process|protein sumoylation|poly(A)+ mRNA export from nucleus|structural constituent of nuclear pore|viral transcription|nuclear membrane|nuclear periphery|host cell|nuclear pore complex assembly|positive regulation of SMAD protein signal transduction|SMAD protein signal transduction|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis NUP98 4492.863843 4919.076837 4066.65085 0.82671017 -0.27454646 0.250800317 1 33.31075878 27.07752618 4928 nucleoporin 98 and 96 precursor "GO:0000776,GO:0003713,GO:0003729,GO:0005215,GO:0005515,GO:0005635,GO:0005643,GO:0005654,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006508,GO:0006606,GO:0006913,GO:0006999,GO:0008139,GO:0008236,GO:0016032,GO:0016604,GO:0016925,GO:0017056,GO:0019083,GO:0031080,GO:0031965,GO:0034399,GO:0042405,GO:0043231,GO:0043657,GO:0044615,GO:0045893,GO:0048026,GO:0051292,GO:0060964,GO:0075733,GO:1900034,GO:1990841,GO:1990904" "kinetochore|transcription coactivator activity|mRNA binding|transporter activity|protein binding|nuclear envelope|nuclear pore|nucleoplasm|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|proteolysis|protein import into nucleus|nucleocytoplasmic transport|nuclear pore organization|nuclear localization sequence binding|serine-type peptidase activity|viral process|nuclear body|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear pore outer ring|nuclear membrane|nuclear periphery|nuclear inclusion body|intracellular membrane-bounded organelle|host cell|nuclear pore nuclear basket|positive regulation of transcription, DNA-templated|positive regulation of mRNA splicing, via spliceosome|nuclear pore complex assembly|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat|promoter-specific chromatin binding|ribonucleoprotein complex" "hsa03013,hsa05014,hsa05164" RNA transport|Amyotrophic lateral sclerosis|Influenza A NUPR1 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.031164627 0 26471 "nuclear protein 1, transcriptional regulator" "GO:0002526,GO:0003677,GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006473,GO:0008285,GO:0008584,GO:0009636,GO:0010506,GO:0010507,GO:0010667,GO:0010698,GO:0031401,GO:0032993,GO:0035914,GO:0042771,GO:0043066,GO:0043433,GO:0043525,GO:0045171,GO:0045786,GO:0045787,GO:0045820,GO:0045893,GO:0048147,GO:0048471,GO:0050680,GO:0050790,GO:0062099,GO:0065003,GO:0150078,GO:1901800,GO:1902902,GO:1903862,GO:1904036,GO:1904691,GO:1905897,GO:2000194,GO:2001244" "acute inflammatory response|DNA binding|chromatin binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|protein acetylation|negative regulation of cell population proliferation|male gonad development|response to toxic substance|regulation of autophagy|negative regulation of autophagy|negative regulation of cardiac muscle cell apoptotic process|acetyltransferase activator activity|positive regulation of protein modification process|protein-DNA complex|skeletal muscle cell differentiation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of apoptotic process|negative regulation of DNA-binding transcription factor activity|positive regulation of neuron apoptotic process|intercellular bridge|negative regulation of cell cycle|positive regulation of cell cycle|negative regulation of glycolytic process|positive regulation of transcription, DNA-templated|negative regulation of fibroblast proliferation|perinuclear region of cytoplasm|negative regulation of epithelial cell proliferation|regulation of catalytic activity|negative regulation of programmed necrotic cell death|protein-containing complex assembly|positive regulation of neuroinflammatory response|positive regulation of proteasomal protein catabolic process|negative regulation of autophagosome assembly|positive regulation of oxidative phosphorylation|negative regulation of epithelial cell apoptotic process|negative regulation of type B pancreatic cell proliferation|regulation of response to endoplasmic reticulum stress|regulation of female gonad development|positive regulation of intrinsic apoptotic signaling pathway" hsa05202 Transcriptional misregulation in cancer NUS1 1449.315201 1460.741091 1437.88931 0.984356036 -0.02274787 0.927189228 1 16.25460119 15.7325712 116150 NUS1 dehydrodolichyl diphosphate synthase subunit "GO:0001525,GO:0004659,GO:0005515,GO:0005789,GO:0006486,GO:0006489,GO:0016021,GO:0019408,GO:0030154,GO:0032383,GO:0035268,GO:0038084,GO:0042632,GO:0043536,GO:0045547,GO:0046872,GO:0051000,GO:1904423" angiogenesis|prenyltransferase activity|protein binding|endoplasmic reticulum membrane|protein glycosylation|dolichyl diphosphate biosynthetic process|integral component of membrane|dolichol biosynthetic process|cell differentiation|regulation of intracellular cholesterol transport|protein mannosylation|vascular endothelial growth factor signaling pathway|cholesterol homeostasis|positive regulation of blood vessel endothelial cell migration|dehydrodolichyl diphosphate synthase activity|metal ion binding|positive regulation of nitric-oxide synthase activity|dehydrodolichyl diphosphate synthase complex hsa00900 Terpenoid backbone biosynthesis NUSAP1 3598.451432 3668.49935 3528.403514 0.961811132 -0.05617447 0.81394375 1 61.60511891 58.26097902 51203 nucleolar and spindle associated protein 1 "GO:0000070,GO:0000281,GO:0003677,GO:0003723,GO:0005515,GO:0005694,GO:0005730,GO:0005737,GO:0007076,GO:0008017,GO:0040001,GO:0045840,GO:0072686" mitotic sister chromatid segregation|mitotic cytokinesis|DNA binding|RNA binding|protein binding|chromosome|nucleolus|cytoplasm|mitotic chromosome condensation|microtubule binding|establishment of mitotic spindle localization|positive regulation of mitotic nuclear division|mitotic spindle NUTF2 2633.424241 2343.012064 2923.836418 1.247896442 0.319498216 0.176699511 1 50.52212023 61.99137839 10204 nuclear transport factor 2 "GO:0005515,GO:0005637,GO:0005640,GO:0005654,GO:0005829,GO:0006606,GO:0006611,GO:0006913,GO:0017056,GO:0031267,GO:0031965,GO:0042307,GO:0042802,GO:0044613,GO:0051028,GO:0061608,GO:0070062,GO:0090204,GO:1904046" protein binding|nuclear inner membrane|nuclear outer membrane|nucleoplasm|cytosol|protein import into nucleus|protein export from nucleus|nucleocytoplasmic transport|structural constituent of nuclear pore|small GTPase binding|nuclear membrane|positive regulation of protein import into nucleus|identical protein binding|nuclear pore central transport channel|mRNA transport|nuclear import signal receptor activity|extracellular exosome|protein localization to nuclear pore|negative regulation of vascular endothelial growth factor production NUTM2A 14.45193789 13.52538047 15.3784953 1.137010181 0.185245172 0.923276611 1 0.112961611 0.126289258 728118 NUT family member 2A NUTM2B 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.050584552 0 729262 NUT family member 2B NUTM2D 32.74346918 39.53572754 25.95121081 0.656398969 -0.607355121 0.396964861 1 0.320856009 0.207085288 728130 NUT family member 2D NUTM2E 53.36869327 38.49531366 68.24207288 1.772737157 0.825978644 0.16000754 1 0.328445106 0.572503731 283008 NUT family member 2E NVL 539.7300424 594.076327 485.3837578 0.817039387 -0.291522468 0.278438381 1 8.753385341 7.032183888 4931 nuclear VCP like "GO:0000176,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005697,GO:0005730,GO:0006364,GO:0016020,GO:0016887,GO:0032092,GO:0042254,GO:0042273,GO:0051973,GO:1904749,GO:1990275" nuclear exosome (RNase complex)|RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|telomerase holoenzyme complex|nucleolus|rRNA processing|membrane|ATPase activity|positive regulation of protein binding|ribosome biogenesis|ribosomal large subunit biogenesis|positive regulation of telomerase activity|regulation of protein localization to nucleolus|preribosome binding hsa03008 Ribosome biogenesis in eukaryotes NXF1 851.6874736 936.3724944 767.0024529 0.819121084 -0.287851365 0.249371007 1 12.21522343 9.838314433 10482 nuclear RNA export factor 1 "GO:0000346,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0006405,GO:0006406,GO:0010494,GO:0016032,GO:0016607,GO:0016973,GO:0042405" transcription export complex|RNA binding|mRNA binding|protein binding|nucleus|nuclear pore|nucleoplasm|cytoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|cytoplasmic stress granule|viral process|nuclear speck|poly(A)+ mRNA export from nucleus|nuclear inclusion body "hsa03008,hsa03013,hsa03015,hsa05014,hsa05164,hsa05168" Ribosome biogenesis in eukaryotes|RNA transport|mRNA surveillance pathway|Amyotrophic lateral sclerosis|Influenza A|Herpes simplex virus 1 infection NXN 1444.758484 1240.173348 1649.34362 1.329929903 0.411350207 0.08544553 1 11.6074662 15.17879715 64359 nucleoredoxin "GO:0001701,GO:0004791,GO:0005634,GO:0005829,GO:0016055,GO:0030154,GO:0030178,GO:0031397,GO:0047134,GO:0055114,GO:0072359,GO:0098869" in utero embryonic development|thioredoxin-disulfide reductase activity|nucleus|cytosol|Wnt signaling pathway|cell differentiation|negative regulation of Wnt signaling pathway|negative regulation of protein ubiquitination|protein-disulfide reductase activity|oxidation-reduction process|circulatory system development|cellular oxidant detoxification NXNL2 28.26478194 22.88910542 33.64045846 1.469714864 0.555536288 0.4717918 1 0.445658332 0.644030293 158046 nucleoredoxin like 2 "GO:0007600,GO:0045494" sensory perception|photoreceptor cell maintenance NXPE2 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.01477252 0.008945862 120406 neurexophilin and PC-esterase domain family member 2 "GO:0005515,GO:0016021" protein binding|integral component of membrane NXPE3 1185.424399 1295.315284 1075.533515 0.830325657 -0.268250816 0.268513632 1 7.847496426 6.406941568 91775 neurexophilin and PC-esterase domain family member 3 "GO:0005515,GO:0005576" protein binding|extracellular region NXPH1 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.017006118 0.061790839 30010 neurexophilin 1 "GO:0005102,GO:0005576" signaling receptor binding|extracellular region NXPH3 63.89171898 62.42483296 65.35860501 1.046996875 0.066257136 0.934231462 1 0.591215369 0.608642506 11248 neurexophilin 3 "GO:0003674,GO:0005102,GO:0005576,GO:0007218" molecular_function|signaling receptor binding|extracellular region|neuropeptide signaling pathway NXPH4 212.969043 216.4060876 209.5319984 0.968235232 -0.046570503 0.909172608 1 8.548627059 8.138576147 11247 neurexophilin 4 "GO:0003674,GO:0005102,GO:0005575,GO:0005576,GO:0007218" molecular_function|signaling receptor binding|cellular_component|extracellular region|neuropeptide signaling pathway NXT1 543.3620445 525.4090107 561.3150783 1.068339269 0.095369871 0.727404715 1 26.40311981 27.73547557 29107 nuclear transport factor 2 like export factor 1 "GO:0005515,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0006406,GO:0006606,GO:0006913,GO:0016607,GO:0031267,GO:0044613" protein binding|nuclear pore|nucleoplasm|cytoplasm|cytosol|mRNA export from nucleus|protein import into nucleus|nucleocytoplasmic transport|nuclear speck|small GTPase binding|nuclear pore central transport channel "hsa03008,hsa03013,hsa03015,hsa05014,hsa05164" Ribosome biogenesis in eukaryotes|RNA transport|mRNA surveillance pathway|Amyotrophic lateral sclerosis|Influenza A NXT2 454.2821259 457.7821084 450.7821434 0.984708959 -0.022230711 0.945126756 1 7.896247497 7.645393095 55916 nuclear transport factor 2 like export factor 2 "GO:0005515,GO:0005654,GO:0005829,GO:0006606,GO:0006913,GO:0044613,GO:0048471,GO:0051028" protein binding|nucleoplasm|cytosol|protein import into nucleus|nucleocytoplasmic transport|nuclear pore central transport channel|perinuclear region of cytoplasm|mRNA transport "hsa03008,hsa03013,hsa03015,hsa05014,hsa05164" Ribosome biogenesis in eukaryotes|RNA transport|mRNA surveillance pathway|Amyotrophic lateral sclerosis|Influenza A NYAP1 80.35025712 65.54607461 95.15443964 1.451718356 0.537761587 0.290787353 1 0.976024981 1.393203254 222950 neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1 "GO:0014065,GO:0048812" phosphatidylinositol 3-kinase signaling|neuron projection morphogenesis NYNRIN 356.8839266 361.0236173 352.7442358 0.977066926 -0.03347071 0.920541857 1 2.172172144 2.08684278 57523 NYN domain and retroviral integrase containing "GO:0003674,GO:0003729,GO:0004521,GO:0005575,GO:0005634,GO:0008150,GO:0015074,GO:0016021,GO:0036464,GO:0090502" "molecular_function|mRNA binding|endoribonuclease activity|cellular_component|nucleus|biological_process|DNA integration|integral component of membrane|cytoplasmic ribonucleoprotein granule|RNA phosphodiester bond hydrolysis, endonucleolytic" OAF 1162.4353 1398.316258 926.5543416 0.662621446 -0.593743196 0.014537219 0.708244576 32.9909676 21.49471643 220323 out at first homolog OARD1 313.5331433 307.9625093 319.1037774 1.036177352 0.051270956 0.878966513 1 4.300207511 4.381216228 221443 O-acyl-ADP-ribose deacylase 1 "GO:0001883,GO:0005515,GO:0005654,GO:0005730,GO:0006974,GO:0042278,GO:0051725,GO:0061463,GO:0090734,GO:0140291,GO:0140293" purine nucleoside binding|protein binding|nucleoplasm|nucleolus|cellular response to DNA damage stimulus|purine nucleoside metabolic process|protein de-ADP-ribosylation|O-acetyl-ADP-ribose deacetylase activity|site of DNA damage|peptidyl-glutamate ADP-deribosylation|ADP-ribosylglutamate hydrolase activity OAS1 83.10980768 74.90979955 91.30981582 1.218930185 0.285615497 0.579939116 1 1.060142754 1.270616116 4938 2'-5'-oligoadenylate synthetase 1 "GO:0001730,GO:0003725,GO:0005515,GO:0005524,GO:0005576,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0006006,GO:0009615,GO:0016020,GO:0042593,GO:0045071,GO:0046872,GO:0051607,GO:0060333,GO:0060337,GO:0060700" 2'-5'-oligoadenylate synthetase activity|double-stranded RNA binding|protein binding|ATP binding|extracellular region|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|glucose metabolic process|response to virus|membrane|glucose homeostasis|negative regulation of viral genome replication|metal ion binding|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|regulation of ribonuclease activity "hsa04621,hsa05160,hsa05162,hsa05164,hsa05168,hsa05169,hsa05171" NOD-like receptor signaling pathway|Hepatitis C|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 OAS2 65.25419499 60.34400519 70.16438479 1.162739937 0.217528454 0.709747442 1 0.645898245 0.738444521 4939 2'-5'-oligoadenylate synthetase 2 "GO:0001730,GO:0003725,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006139,GO:0006401,GO:0009615,GO:0009617,GO:0016020,GO:0043231,GO:0045071,GO:0046872,GO:0048471,GO:0051607,GO:0060333,GO:0060337,GO:0060700,GO:1903487" 2'-5'-oligoadenylate synthetase activity|double-stranded RNA binding|protein binding|ATP binding|nucleoplasm|cytosol|nucleobase-containing compound metabolic process|RNA catabolic process|response to virus|response to bacterium|membrane|intracellular membrane-bounded organelle|negative regulation of viral genome replication|metal ion binding|perinuclear region of cytoplasm|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|regulation of ribonuclease activity|regulation of lactation "hsa04621,hsa05160,hsa05162,hsa05164,hsa05168,hsa05169,hsa05171" NOD-like receptor signaling pathway|Hepatitis C|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 OAS3 1328.471862 1505.478888 1151.464835 0.76484954 -0.386752124 0.107476776 1 12.15501381 9.141188092 4940 2'-5'-oligoadenylate synthetase 3 "GO:0001730,GO:0003725,GO:0005515,GO:0005524,GO:0005615,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0009615,GO:0016020,GO:0043231,GO:0045071,GO:0046872,GO:0051607,GO:0060333,GO:0060337,GO:0060700" 2'-5'-oligoadenylate synthetase activity|double-stranded RNA binding|protein binding|ATP binding|extracellular space|nucleoplasm|cytoplasm|cytosol|plasma membrane|nucleobase-containing compound metabolic process|response to virus|membrane|intracellular membrane-bounded organelle|negative regulation of viral genome replication|metal ion binding|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|regulation of ribonuclease activity "hsa04621,hsa05160,hsa05162,hsa05164,hsa05168,hsa05169,hsa05171" NOD-like receptor signaling pathway|Hepatitis C|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 OASL 381.1053255 479.6307999 282.5798511 0.589161186 -0.763265706 0.009274288 0.589887864 11.45792939 6.637605673 8638 2'-5'-oligoadenylate synthetase like "GO:0001730,GO:0003677,GO:0003723,GO:0003725,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0009615,GO:0016020,GO:0045071,GO:0046966,GO:0051607,GO:0060333,GO:0060337,GO:0060700" 2'-5'-oligoadenylate synthetase activity|DNA binding|RNA binding|double-stranded RNA binding|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|response to virus|membrane|negative regulation of viral genome replication|thyroid hormone receptor binding|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|regulation of ribonuclease activity hsa05165 Human papillomavirus infection OAT 1650.364758 1540.85296 1759.876555 1.142144384 0.191745041 0.420434748 1 19.0045044 21.34266933 4942 ornithine aminotransferase "GO:0004587,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0007601,GO:0008652,GO:0010121,GO:0019544,GO:0030170,GO:0042802,GO:0050155,GO:0055129" ornithine-oxo-acid transaminase activity|protein binding|nucleoplasm|cytoplasm|mitochondrion|mitochondrial matrix|visual perception|cellular amino acid biosynthetic process|arginine catabolic process to proline via ornithine|arginine catabolic process to glutamate|pyridoxal phosphate binding|identical protein binding|ornithine(lysine) transaminase activity|L-proline biosynthetic process hsa00330 Arginine and proline metabolism OAZ1 7350.107745 6589.981533 8110.233957 1.230691454 0.29946911 0.222128125 1 297.7944137 360.3602753 4946 ornithine decarboxylase antizyme 1 "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006521,GO:0006596,GO:0008073,GO:0043086,GO:0045732,GO:0090316,GO:1902268" protein binding|nucleus|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|polyamine biosynthetic process|ornithine decarboxylase inhibitor activity|negative regulation of catalytic activity|positive regulation of protein catabolic process|positive regulation of intracellular protein transport|negative regulation of polyamine transmembrane transport OAZ2 1717.309136 1481.549369 1953.068903 1.318261101 0.398636146 0.093215257 1 40.88291978 52.99251367 4947 ornithine decarboxylase antizyme 2 "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006521,GO:0006595,GO:0006596,GO:0008073,GO:0043086,GO:0045732,GO:0090316,GO:1902268" protein binding|nucleus|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|polyamine metabolic process|polyamine biosynthetic process|ornithine decarboxylase inhibitor activity|negative regulation of catalytic activity|positive regulation of protein catabolic process|positive regulation of intracellular protein transport|negative regulation of polyamine transmembrane transport OAZ3 9.046693237 10.40413883 7.689247648 0.739056617 -0.436243205 0.791668951 1 0.4737626 0.34427831 51686 ornithine decarboxylase antizyme 3 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006521,GO:0006596,GO:0007283,GO:0008073,GO:0043086,GO:0045732,GO:0072562,GO:1902268" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|polyamine biosynthetic process|spermatogenesis|ornithine decarboxylase inhibitor activity|negative regulation of catalytic activity|positive regulation of protein catabolic process|blood microparticle|negative regulation of polyamine transmembrane transport OBI1 739.0403411 716.8451651 761.2355171 1.061924603 0.086681337 0.737186401 1 10.74023272 11.21446483 79596 ORC ubiquitin ligase 1 "GO:0000785,GO:0003682,GO:0004842,GO:0005515,GO:0006275,GO:0006513,GO:0046872,GO:0051865" chromatin|chromatin binding|ubiquitin-protein transferase activity|protein binding|regulation of DNA replication|protein monoubiquitination|metal ion binding|protein autoubiquitination OBSCN 201.8314612 226.8102264 176.8526959 0.779738633 -0.358937479 0.323608458 1 0.421552028 0.323200046 84033 "obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF" "GO:0005085,GO:0005515,GO:0005516,GO:0005524,GO:0005546,GO:0005547,GO:0005829,GO:0005886,GO:0005887,GO:0005911,GO:0006468,GO:0007186,GO:0007275,GO:0008307,GO:0010314,GO:0016604,GO:0030016,GO:0030018,GO:0030506,GO:0031430,GO:0031432,GO:0032266,GO:0036309,GO:0042383,GO:0043065,GO:0043325,GO:0045214,GO:0046872,GO:0050790,GO:0050839,GO:0051056,GO:0070273,GO:0098609,GO:0106310,GO:0106311" "guanyl-nucleotide exchange factor activity|protein binding|calmodulin binding|ATP binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytosol|plasma membrane|integral component of plasma membrane|cell-cell junction|protein phosphorylation|G protein-coupled receptor signaling pathway|multicellular organism development|structural constituent of muscle|phosphatidylinositol-5-phosphate binding|nuclear body|myofibril|Z disc|ankyrin binding|M band|titin binding|phosphatidylinositol-3-phosphate binding|protein localization to M-band|sarcolemma|positive regulation of apoptotic process|phosphatidylinositol-3,4-bisphosphate binding|sarcomere organization|metal ion binding|regulation of catalytic activity|cell adhesion molecule binding|regulation of small GTPase mediated signal transduction|phosphatidylinositol-4-phosphate binding|cell-cell adhesion|protein serine kinase activity|protein threonine kinase activity" OBSL1 576.4917425 600.3188103 552.6646747 0.92061862 -0.119324473 0.656629433 1 4.318359828 3.909036812 23363 obscurin like cytoskeletal adaptor 1 "GO:0000226,GO:0005515,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0007010,GO:0007030,GO:0007088,GO:0007156,GO:0007416,GO:0008093,GO:0010842,GO:0014704,GO:0030018,GO:0031430,GO:0034067,GO:0043687,GO:0045202,GO:0048471,GO:0050775,GO:0055003,GO:1990393" microtubule cytoskeleton organization|protein binding|cytoplasm|Golgi apparatus|centrosome|cytosol|cytoskeleton organization|Golgi organization|regulation of mitotic nuclear division|homophilic cell adhesion via plasma membrane adhesion molecules|synapse assembly|cytoskeletal anchor activity|retina layer formation|intercalated disc|Z disc|M band|protein localization to Golgi apparatus|post-translational protein modification|synapse|perinuclear region of cytoplasm|positive regulation of dendrite morphogenesis|cardiac myofibril assembly|3M complex OCEL1 210.937905 188.3149128 233.5608973 1.240267666 0.310651507 0.386507197 1 8.754373507 10.67607638 79629 occludin/ELL domain containing 1 OCIAD1 2538.457271 2474.104213 2602.810329 1.052021299 0.073163914 0.758154619 1 73.11096048 75.6272312 54940 OCIA domain containing 1 "GO:0005515,GO:0005764,GO:0005768,GO:0005794,GO:0016020,GO:0019731,GO:0046427,GO:1902037,GO:2000736" protein binding|lysosome|endosome|Golgi apparatus|membrane|antibacterial humoral response|positive regulation of receptor signaling pathway via JAK-STAT|negative regulation of hematopoietic stem cell differentiation|regulation of stem cell differentiation OCIAD2 1951.64948 2031.928313 1871.370646 0.920982613 -0.118754175 0.61693016 1 95.79529994 86.74946624 132299 OCIA domain containing 2 "GO:0005764,GO:0005768,GO:0005794,GO:0019731,GO:0046427,GO:1902037" lysosome|endosome|Golgi apparatus|antibacterial humoral response|positive regulation of receptor signaling pathway via JAK-STAT|negative regulation of hematopoietic stem cell differentiation OCLN 211.6361351 244.4972624 178.7750078 0.731194313 -0.451673245 0.204537287 1 2.064288804 1.484138532 100506658 occludin "GO:0001933,GO:0005515,GO:0005765,GO:0005886,GO:0005911,GO:0005923,GO:0010592,GO:0010628,GO:0010629,GO:0010827,GO:0016021,GO:0016324,GO:0016327,GO:0016328,GO:0019904,GO:0030054,GO:0030139,GO:0031116,GO:0031252,GO:0031410,GO:0032991,GO:0035633,GO:0045216,GO:0046326,GO:0065003,GO:0070160,GO:0070673,GO:0070830,GO:0071356,GO:0090303,GO:1902463,GO:1905605,GO:2000810" negative regulation of protein phosphorylation|protein binding|lysosomal membrane|plasma membrane|cell-cell junction|bicellular tight junction|positive regulation of lamellipodium assembly|positive regulation of gene expression|negative regulation of gene expression|regulation of glucose transmembrane transport|integral component of membrane|apical plasma membrane|apicolateral plasma membrane|lateral plasma membrane|protein domain specific binding|cell junction|endocytic vesicle|positive regulation of microtubule polymerization|cell leading edge|cytoplasmic vesicle|protein-containing complex|maintenance of blood-brain barrier|cell-cell junction organization|positive regulation of glucose import|protein-containing complex assembly|tight junction|response to interleukin-18|bicellular tight junction assembly|cellular response to tumor necrosis factor|positive regulation of wound healing|protein localization to cell leading edge|positive regulation of blood-brain barrier permeability|regulation of bicellular tight junction assembly "hsa04514,hsa04530,hsa04670,hsa05130,hsa05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C OCRL 3522.541462 3416.719191 3628.363734 1.061943792 0.086707407 0.715647385 1 35.22875262 36.78493347 4952 OCRL inositol polyphosphate-5-phosphatase "GO:0001750,GO:0004439,GO:0004445,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005769,GO:0005795,GO:0005798,GO:0005802,GO:0005829,GO:0005886,GO:0005905,GO:0006629,GO:0006661,GO:0007165,GO:0016020,GO:0030136,GO:0030670,GO:0031267,GO:0031901,GO:0043087,GO:0043547,GO:0043647,GO:0046855,GO:0046856,GO:0051056,GO:0052658,GO:0052659,GO:0052745,GO:0060271,GO:0061024" "photoreceptor outer segment|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|GTPase activator activity|protein binding|nucleus|cytoplasm|lysosome|early endosome|Golgi stack|Golgi-associated vesicle|trans-Golgi network|cytosol|plasma membrane|clathrin-coated pit|lipid metabolic process|phosphatidylinositol biosynthetic process|signal transduction|membrane|clathrin-coated vesicle|phagocytic vesicle membrane|small GTPase binding|early endosome membrane|regulation of GTPase activity|positive regulation of GTPase activity|inositol phosphate metabolic process|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|regulation of small GTPase mediated signal transduction|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol phosphate phosphatase activity|cilium assembly|membrane organization" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system ODAD1 5.965080553 5.202069413 6.728091692 1.29334908 0.371111717 0.919461532 1 0.090402111 0.114964965 93233 outer dynein arm docking complex subunit 1 "GO:0003341,GO:0005515,GO:0005929,GO:0005930,GO:0036157,GO:0036158" cilium movement|protein binding|cilium|axoneme|outer dynein arm|outer dynein arm assembly ODAD2 17.25614783 11.44455271 23.06774294 2.015608957 1.011215772 0.273875636 1 0.131151974 0.259927536 55130 outer dynein arm docking complex subunit 2 "GO:0003341,GO:0003356,GO:0005515,GO:0005930,GO:0007368,GO:0007507,GO:0021591,GO:0036158,GO:0097546" cilium movement|regulation of cilium beat frequency|protein binding|axoneme|determination of left/right symmetry|heart development|ventricular system development|outer dynein arm assembly|ciliary base ODAD3 9.368755362 6.242483296 12.49502743 2.001611672 1.001162108 0.427900976 1 0.147935107 0.291153659 115948 outer dynein arm docking complex subunit 3 "GO:0003341,GO:0005515,GO:0005814,GO:0005929,GO:0005930,GO:0007368,GO:0036064,GO:0036158,GO:1902017" cilium movement|protein binding|centriole|cilium|axoneme|determination of left/right symmetry|ciliary basal body|outer dynein arm assembly|regulation of cilium assembly ODAD4 7.604959303 10.40413883 4.80577978 0.461910386 -1.11431511 0.425432296 1 0.176493887 0.08016016 83538 outer dynein arm docking complex subunit 4 "GO:0003341,GO:0005515,GO:0005576,GO:0005737,GO:0005930,GO:0007420,GO:0007507,GO:0030324,GO:0036158,GO:0060287,GO:0090660,GO:0097729,GO:0120197,GO:0120228,GO:0120229" cilium movement|protein binding|extracellular region|cytoplasm|axoneme|brain development|heart development|lung development|outer dynein arm assembly|epithelial cilium movement involved in determination of left/right asymmetry|cerebrospinal fluid circulation|9+2 motile cilium|mucociliary clearance|outer dynein arm docking complex|protein localization to motile cilium ODAPH 6.004709516 6.242483296 5.766935736 0.923820772 -0.11431511 1 1 0.115636883 0.105040137 152816 odontogenesis associated phosphoprotein "GO:0005515,GO:0005576,GO:0070169,GO:0070175" protein binding|extracellular region|positive regulation of biomineral tissue development|positive regulation of enamel mineralization ODC1 4450.265281 4191.827533 4708.703028 1.123305525 0.167750376 0.482869675 1 74.19904849 81.95348186 4953 ornithine decarboxylase 1 "GO:0004586,GO:0005515,GO:0005575,GO:0005737,GO:0005829,GO:0006521,GO:0006595,GO:0009615,GO:0033387,GO:0042176,GO:0042803,GO:0048471" ornithine decarboxylase activity|protein binding|cellular_component|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|polyamine metabolic process|response to virus|putrescine biosynthetic process from ornithine|regulation of protein catabolic process|protein homodimerization activity|perinuclear region of cytoplasm "hsa00330,hsa00480" Arginine and proline metabolism|Glutathione metabolism ODF2 1541.163502 1714.602079 1367.724925 0.797692329 -0.326095691 0.171231828 1 19.41548093 15.22841652 4957 outer dense fiber of sperm tails 2 "GO:0000086,GO:0000922,GO:0001520,GO:0005198,GO:0005515,GO:0005634,GO:0005813,GO:0005814,GO:0005829,GO:0005874,GO:0007275,GO:0007286,GO:0008104,GO:0010389,GO:0010457,GO:0036126,GO:0044782,GO:0097539,GO:0097711,GO:0120103" G2/M transition of mitotic cell cycle|spindle pole|outer dense fiber|structural molecule activity|protein binding|nucleus|centrosome|centriole|cytosol|microtubule|multicellular organism development|spermatid development|protein localization|regulation of G2/M transition of mitotic cell cycle|centriole-centriole cohesion|sperm flagellum|cilium organization|ciliary transition fiber|ciliary basal body-plasma membrane docking|centriolar subdistal appendage ODF2L 501.0762129 512.9240441 489.2283816 0.953802785 -0.0682371 0.809127513 1 6.204400164 5.818748217 57489 outer dense fiber of sperm tails 2 like "GO:0005737,GO:0005813,GO:0005814,GO:0030030,GO:0034451,GO:0036064,GO:1902018" cytoplasm|centrosome|centriole|cell projection organization|centriolar satellite|ciliary basal body|negative regulation of cilium assembly ODF3B 44.47548546 44.73779695 44.21317398 0.988273384 -0.017017909 1 1 2.534579617 2.462942175 440836 outer dense fiber of sperm tails 3B "GO:0005515,GO:0005856" protein binding|cytoskeleton ODR4 523.5639982 560.7830827 486.3449137 0.867260316 -0.205462998 0.449580666 1 7.49510705 6.391436718 54953 odr-4 GPCR localization factor homolog "GO:0008104,GO:0016021" protein localization|integral component of membrane OFD1 440.5089108 449.4587973 431.5590242 0.96017483 -0.058630977 0.842704496 1 5.779949384 5.456894166 8481 OFD1 centriole and centriolar satellite protein "GO:0000086,GO:0000278,GO:0005515,GO:0005576,GO:0005634,GO:0005813,GO:0005814,GO:0005829,GO:0005929,GO:0007099,GO:0010389,GO:0015630,GO:0016020,GO:0031514,GO:0034451,GO:0036064,GO:0042802,GO:0043014,GO:0043015,GO:0060271,GO:0060287,GO:0090307,GO:0097711" G2/M transition of mitotic cell cycle|mitotic cell cycle|protein binding|extracellular region|nucleus|centrosome|centriole|cytosol|cilium|centriole replication|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|membrane|motile cilium|centriolar satellite|ciliary basal body|identical protein binding|alpha-tubulin binding|gamma-tubulin binding|cilium assembly|epithelial cilium movement involved in determination of left/right asymmetry|mitotic spindle assembly|ciliary basal body-plasma membrane docking OGA 8545.490419 8714.506681 8376.474156 0.961210366 -0.057075888 0.818271368 1 78.11172405 73.82540664 10724 O-GlcNAcase "GO:0004415,GO:0005634,GO:0005829,GO:0006044,GO:0006493,GO:0006516,GO:0006517,GO:0009100,GO:0016020,GO:0016032,GO:0016231,GO:0102166,GO:0102167,GO:0102571" hyalurononglucosaminidase activity|nucleus|cytosol|N-acetylglucosamine metabolic process|protein O-linked glycosylation|glycoprotein catabolic process|protein deglycosylation|glycoprotein metabolic process|membrane|viral process|beta-N-acetylglucosaminidase activity|[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity|[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity|[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity hsa04931 Insulin resistance OGDH 2184.237931 2258.738539 2109.737323 0.934033438 -0.098453896 0.678213684 1 26.81751378 24.62930263 4967 oxoglutarate dehydrogenase "GO:0004591,GO:0005515,GO:0005634,GO:0005739,GO:0005759,GO:0006091,GO:0006096,GO:0006099,GO:0006103,GO:0006104,GO:0006554,GO:0030976,GO:0031966,GO:0045252,GO:0046872,GO:0106077" oxoglutarate dehydrogenase (succinyl-transferring) activity|protein binding|nucleus|mitochondrion|mitochondrial matrix|generation of precursor metabolites and energy|glycolytic process|tricarboxylic acid cycle|2-oxoglutarate metabolic process|succinyl-CoA metabolic process|lysine catabolic process|thiamine pyrophosphate binding|mitochondrial membrane|oxoglutarate dehydrogenase complex|metal ion binding|histone succinylation hsa00020 Citrate cycle (TCA cycle) OGDHL 21.9380103 20.80827765 23.06774294 1.108584926 0.148719296 0.913376404 1 0.281566819 0.306917479 55753 oxoglutarate dehydrogenase L "GO:0004591,GO:0005515,GO:0005739,GO:0005759,GO:0006096,GO:0006099,GO:0030976,GO:0045252,GO:0046872" oxoglutarate dehydrogenase (succinyl-transferring) activity|protein binding|mitochondrion|mitochondrial matrix|glycolytic process|tricarboxylic acid cycle|thiamine pyrophosphate binding|oxoglutarate dehydrogenase complex|metal ion binding hsa00020 Citrate cycle (TCA cycle) OGFOD1 1457.901438 1421.205364 1494.597512 1.051640776 0.072641987 0.76337829 1 14.81967921 15.32418543 55239 2-oxoglutarate and iron dependent oxygenase domain containing 1 "GO:0005506,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006449,GO:0008283,GO:0010494,GO:0018126,GO:0019511,GO:0031418,GO:0031543,GO:0031544,GO:0034063,GO:0055114" iron ion binding|protein binding|nucleoplasm|cytoplasm|cytosol|regulation of translational termination|cell population proliferation|cytoplasmic stress granule|protein hydroxylation|peptidyl-proline hydroxylation|L-ascorbic acid binding|peptidyl-proline dioxygenase activity|peptidyl-proline 3-dioxygenase activity|stress granule assembly|oxidation-reduction process OGFOD2 224.1412234 219.5273292 228.7551175 1.042034804 0.059403465 0.877205846 1 4.558665404 4.670798374 79676 2-oxoglutarate and iron dependent oxygenase domain containing 2 "GO:0005506,GO:0016705,GO:0031418,GO:0051213,GO:0055114" "iron ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|L-ascorbic acid binding|dioxygenase activity|oxidation-reduction process" OGFOD3 498.9507257 520.2069413 477.6945101 0.918277847 -0.122997353 0.657464092 1 6.221983048 5.617901359 79701 2-oxoglutarate and iron dependent oxygenase domain containing 3 "GO:0005506,GO:0016020,GO:0016021,GO:0016705,GO:0031418,GO:0051213,GO:0055114" "iron ion binding|membrane|integral component of membrane|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|L-ascorbic acid binding|dioxygenase activity|oxidation-reduction process" OGFR 1890.557554 1878.987472 1902.127637 1.012315231 0.01765861 0.942944329 1 41.60917342 41.41675208 11054 opioid growth factor receptor "GO:0001558,GO:0004985,GO:0005515,GO:0005575,GO:0005634,GO:0005737,GO:0016020,GO:0038003" regulation of cell growth|opioid receptor activity|protein binding|cellular_component|nucleus|cytoplasm|membrane|opioid receptor signaling pathway OGFRL1 4631.472132 4318.758027 4944.186238 1.144816683 0.195116601 0.41499998 1 20.49112539 23.06603459 79627 opioid growth factor receptor like 1 "GO:0004985,GO:0016020,GO:0038003" opioid receptor activity|membrane|opioid receptor signaling pathway OGG1 342.075328 338.1345119 346.0161442 1.023309163 0.033242079 0.922625399 1 3.751687616 3.774893566 4968 8-oxoguanine DNA glycosylase "GO:0002526,GO:0003684,GO:0004519,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006284,GO:0006285,GO:0006355,GO:0006974,GO:0006979,GO:0007568,GO:0008017,GO:0008534,GO:0009314,GO:0009416,GO:0016363,GO:0016607,GO:0032355,GO:0032357,GO:0032991,GO:0033683,GO:0034039,GO:0042493,GO:0043066,GO:0045007,GO:0045008,GO:0045471,GO:0051593,GO:0071276,GO:0140078,GO:1901291" "acute inflammatory response|damaged DNA binding|endonuclease activity|protein binding|nucleus|nucleoplasm|mitochondrion|base-excision repair|base-excision repair, AP site formation|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|response to oxidative stress|aging|microtubule binding|oxidized purine nucleobase lesion DNA N-glycosylase activity|response to radiation|response to light stimulus|nuclear matrix|nuclear speck|response to estradiol|oxidized purine DNA binding|protein-containing complex|nucleotide-excision repair, DNA incision|8-oxo-7,8-dihydroguanine DNA N-glycosylase activity|response to drug|negative regulation of apoptotic process|depurination|depyrimidination|response to ethanol|response to folic acid|cellular response to cadmium ion|class I DNA-(apurinic or apyrimidinic site) endonuclease activity|negative regulation of double-strand break repair via single-strand annealing" hsa03410 Base excision repair OGT 6428.788228 6916.671492 5940.904964 0.85892542 -0.219395227 0.366887137 1 68.52237706 57.87074252 8473 O-linked N-acetylglucosamine (GlcNAc) transferase "GO:0000123,GO:0005515,GO:0005547,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006110,GO:0006111,GO:0006357,GO:0006493,GO:0006915,GO:0007165,GO:0007584,GO:0008375,GO:0016032,GO:0016262,GO:0016485,GO:0016579,GO:0017122,GO:0018215,GO:0031397,GO:0031966,GO:0032435,GO:0032868,GO:0032922,GO:0032991,GO:0035020,GO:0042995,GO:0043981,GO:0043982,GO:0043984,GO:0045862,GO:0045944,GO:0046626,GO:0048015,GO:0061087,GO:0080182,GO:0097363,GO:0120162" "histone acetyltransferase complex|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|nucleoplasm|cytosol|plasma membrane|regulation of glycolytic process|regulation of gluconeogenesis|regulation of transcription by RNA polymerase II|protein O-linked glycosylation|apoptotic process|signal transduction|response to nutrient|acetylglucosaminyltransferase activity|viral process|protein N-acetylglucosaminyltransferase activity|protein processing|protein deubiquitination|protein N-acetylglucosaminyltransferase complex|protein phosphopantetheinylation|negative regulation of protein ubiquitination|mitochondrial membrane|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|response to insulin|circadian regulation of gene expression|protein-containing complex|regulation of Rac protein signal transduction|cell projection|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|positive regulation of proteolysis|positive regulation of transcription by RNA polymerase II|regulation of insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of histone H3-K27 methylation|histone H3-K4 trimethylation|protein O-GlcNAc transferase activity|positive regulation of cold-induced thermogenesis" "hsa00514,hsa04931" Other types of O-glycan biosynthesis|Insulin resistance other OIP5 134.9027889 147.7387713 122.0668064 0.826234071 -0.275377543 0.520859844 1 6.564984758 5.333447202 11339 Opa interacting protein 5 "GO:0000775,GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0007049,GO:0007059,GO:0007154,GO:0010369,GO:0015030,GO:0016607,GO:0034080,GO:0042802,GO:0043231,GO:0046872,GO:0051301" "chromosome, centromeric region|chromatin|protein binding|nucleus|nucleoplasm|cell cycle|chromosome segregation|cell communication|chromocenter|Cajal body|nuclear speck|CENP-A containing nucleosome assembly|identical protein binding|intracellular membrane-bounded organelle|metal ion binding|cell division" OLA1 3886.690007 3539.488029 4233.891986 1.196187684 0.258443768 0.277511123 1 44.43565533 52.26393372 29789 Obg like ATPase 1 "GO:0002576,GO:0005515,GO:0005524,GO:0005525,GO:0005576,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0016020,GO:0016887,GO:0031093,GO:0043022,GO:0043023,GO:0045296,GO:0046034,GO:0046872,GO:0070062" platelet degranulation|protein binding|ATP binding|GTP binding|extracellular region|nucleolus|cytoplasm|centrosome|cytosol|membrane|ATPase activity|platelet alpha granule lumen|ribosome binding|ribosomal large subunit binding|cadherin binding|ATP metabolic process|metal ion binding|extracellular exosome OLAH 14.80859856 22.88910542 6.728091692 0.293942973 -1.766391806 0.073055442 1 0.621337481 0.17958159 55301 oleoyl-ACP hydrolase "GO:0004320,GO:0005829,GO:0008610,GO:0016295,GO:0016296,GO:0047381,GO:0051792" oleoyl-[acyl-carrier-protein] hydrolase activity|cytosol|lipid biosynthetic process|myristoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|dodecanoyl-[acyl-carrier-protein] hydrolase activity|medium-chain fatty acid biosynthetic process hsa00061 Fatty acid biosynthesis OLFML2A 304.9318151 384.9531366 224.9104937 0.584254218 -0.775331851 0.013311263 0.686911403 3.035496659 1.743824576 169611 olfactomedin like 2A "GO:0030198,GO:0031012,GO:0042802,GO:0050840" extracellular matrix organization|extracellular matrix|identical protein binding|extracellular matrix binding OLFML2B 19.01491347 19.76786377 18.26196316 0.923820772 -0.11431511 0.961214943 1 0.107859581 0.097975532 25903 olfactomedin like 2B GO:0005576 extracellular region OLFML3 5.965080553 5.202069413 6.728091692 1.29334908 0.371111717 0.919461532 1 0.121818729 0.154917686 56944 olfactomedin like 3 "GO:0007275,GO:1903561" multicellular organism development|extracellular vesicle OMA1 134.6203557 152.9408407 116.2998707 0.760423901 -0.395124217 0.352035893 1 4.385906275 3.279338773 115209 OMA1 zinc metallopeptidase "GO:0002024,GO:0004222,GO:0005743,GO:0006006,GO:0006515,GO:0006629,GO:0008289,GO:0010637,GO:0016021,GO:0016540,GO:0031638,GO:0031966,GO:0033108,GO:0034982,GO:0042981,GO:0043065,GO:0046872,GO:0097009,GO:0120162,GO:0140467,GO:0140468,GO:1903850" diet induced thermogenesis|metalloendopeptidase activity|mitochondrial inner membrane|glucose metabolic process|protein quality control for misfolded or incompletely synthesized proteins|lipid metabolic process|lipid binding|negative regulation of mitochondrial fusion|integral component of membrane|protein autoprocessing|zymogen activation|mitochondrial membrane|mitochondrial respiratory chain complex assembly|mitochondrial protein processing|regulation of apoptotic process|positive regulation of apoptotic process|metal ion binding|energy homeostasis|positive regulation of cold-induced thermogenesis|integrated stress response signaling|HRI-mediated signaling|regulation of cristae formation hsa05017 Spinocerebellar ataxia OMP 4.082397604 6.242483296 1.922311912 0.307940257 -1.699277611 0.406294648 1 0.677133862 0.20502753 4975 olfactory marker protein "GO:0005634,GO:0005829,GO:0007165,GO:0007268,GO:0007608,GO:0022008,GO:0030424,GO:0043025,GO:0045202" nucleus|cytosol|signal transduction|chemical synaptic transmission|sensory perception of smell|neurogenesis|axon|neuronal cell body|synapse ONECUT2 138.3064637 148.7791852 127.8337421 0.859217921 -0.218904011 0.609917837 1 0.483178462 0.408208527 9480 one cut homeobox 2 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001889,GO:0001952,GO:0002064,GO:0005634,GO:0005654,GO:0006357,GO:0009887,GO:0015629,GO:0030335,GO:0030512,GO:0031018,GO:0045165,GO:0045944,GO:0048935,GO:0060271,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|liver development|regulation of cell-matrix adhesion|epithelial cell development|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|animal organ morphogenesis|actin cytoskeleton|positive regulation of cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|endocrine pancreas development|cell fate commitment|positive regulation of transcription by RNA polymerase II|peripheral nervous system neuron development|cilium assembly|sequence-specific double-stranded DNA binding" OPA1 2172.629832 2244.172745 2101.08692 0.936241172 -0.095047885 0.68883892 1 18.46267532 16.99626705 4976 OPA1 mitochondrial dynamin like GTPase "GO:0000002,GO:0000266,GO:0000287,GO:0001843,GO:0003374,GO:0003924,GO:0005515,GO:0005525,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005743,GO:0005758,GO:0005829,GO:0006915,GO:0007005,GO:0007007,GO:0007601,GO:0008017,GO:0008053,GO:0010636,GO:0014042,GO:0014850,GO:0016020,GO:0016021,GO:0019896,GO:0019900,GO:0030061,GO:0030425,GO:0031314,GO:0031667,GO:0031966,GO:0036444,GO:0043066,GO:0044877,GO:0046039,GO:0046628,GO:0048285,GO:0048312,GO:0051259,GO:0051602,GO:0060041,GO:0061003,GO:0061025,GO:0070300,GO:0070584,GO:0071333,GO:0071456,GO:0090102,GO:0090201,GO:0090398,GO:0097749,GO:1900006,GO:1901612,GO:1902236,GO:1904115,GO:1904643,GO:1905232" mitochondrial genome maintenance|mitochondrial fission|magnesium ion binding|neural tube closure|dynamin family protein polymerization involved in mitochondrial fission|GTPase activity|protein binding|GTP binding|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial intermembrane space|cytosol|apoptotic process|mitochondrion organization|inner mitochondrial membrane organization|visual perception|microtubule binding|mitochondrial fusion|positive regulation of mitochondrial fusion|positive regulation of neuron maturation|response to muscle activity|membrane|integral component of membrane|axonal transport of mitochondrion|kinase binding|mitochondrial crista|dendrite|extrinsic component of mitochondrial inner membrane|response to nutrient levels|mitochondrial membrane|calcium import into the mitochondrion|negative regulation of apoptotic process|protein-containing complex binding|GTP metabolic process|positive regulation of insulin receptor signaling pathway|organelle fission|intracellular distribution of mitochondria|protein complex oligomerization|response to electrical stimulus|retina development in camera-type eye|positive regulation of dendritic spine morphogenesis|membrane fusion|phosphatidic acid binding|mitochondrion morphogenesis|cellular response to glucose stimulus|cellular response to hypoxia|cochlea development|negative regulation of release of cytochrome c from mitochondria|cellular senescence|membrane tubulation|positive regulation of dendrite development|cardiolipin binding|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|axon cytoplasm|response to curcumin|cellular response to L-glutamate hsa05017 Spinocerebellar ataxia OPA3 607.76894 601.3592242 614.1786559 1.021317428 0.030431329 0.914154494 1 3.253262701 3.267014449 80207 outer mitochondrial membrane lipid metabolism regulator OPA3 "GO:0005739,GO:0007601,GO:0019216,GO:0050896" mitochondrion|visual perception|regulation of lipid metabolic process|response to stimulus OPHN1 849.2807821 747.0171677 951.5443964 1.273791872 0.349129571 0.162450794 1 3.767072974 4.718171089 4983 oligophrenin 1 "GO:0003779,GO:0005096,GO:0005543,GO:0005737,GO:0005829,GO:0006930,GO:0007165,GO:0007399,GO:0007411,GO:0015629,GO:0021707,GO:0021895,GO:0030036,GO:0030100,GO:0030182,GO:0031175,GO:0034329,GO:0035023,GO:0035255,GO:0043195,GO:0043197,GO:0043547,GO:0045198,GO:0048488,GO:0048667,GO:0051056,GO:0051966,GO:0098880,GO:0098978,GO:0099149,GO:1901799" "actin binding|GTPase activator activity|phospholipid binding|cytoplasm|cytosol|substrate-dependent cell migration, cell extension|signal transduction|nervous system development|axon guidance|actin cytoskeleton|cerebellar granule cell differentiation|cerebral cortex neuron differentiation|actin cytoskeleton organization|regulation of endocytosis|neuron differentiation|neuron projection development|cell junction assembly|regulation of Rho protein signal transduction|ionotropic glutamate receptor binding|terminal bouton|dendritic spine|positive regulation of GTPase activity|establishment of epithelial cell apical/basal polarity|synaptic vesicle endocytosis|cell morphogenesis involved in neuron differentiation|regulation of small GTPase mediated signal transduction|regulation of synaptic transmission, glutamatergic|maintenance of postsynaptic specialization structure|glutamatergic synapse|regulation of postsynaptic neurotransmitter receptor internalization|negative regulation of proteasomal protein catabolic process" OPLAH 415.8258268 482.7520415 348.899612 0.722730474 -0.468470367 0.101384173 1 5.926751598 4.21176636 26873 "5-oxoprolinase, ATP-hydrolysing" "GO:0005515,GO:0005524,GO:0005829,GO:0006749,GO:0006750,GO:0017168,GO:0042802" protein binding|ATP binding|cytosol|glutathione metabolic process|glutathione biosynthetic process|5-oxoprolinase (ATP-hydrolyzing) activity|identical protein binding hsa00480 Glutathione metabolism OPN3 207.8066025 207.0423626 208.5708425 1.00738245 0.010611502 0.991757657 1 1.121659767 1.111032342 23596 opsin 3 "GO:0001750,GO:0004930,GO:0005502,GO:0005503,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007602,GO:0008020,GO:0009583,GO:0009584,GO:0009637,GO:0009881,GO:0016021,GO:0018298,GO:0030216,GO:0042752,GO:0043066,GO:0046326,GO:0048022,GO:0048023,GO:0071482,GO:0071492,GO:1901857" photoreceptor outer segment|G protein-coupled receptor activity|11-cis retinal binding|all-trans retinal binding|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|phototransduction|G protein-coupled photoreceptor activity|detection of light stimulus|detection of visible light|response to blue light|photoreceptor activity|integral component of membrane|protein-chromophore linkage|keratinocyte differentiation|regulation of circadian rhythm|negative regulation of apoptotic process|positive regulation of glucose import|negative regulation of melanin biosynthetic process|positive regulation of melanin biosynthetic process|cellular response to light stimulus|cellular response to UV-A|positive regulation of cellular respiration OPRL1 25.62411827 16.64662212 34.60161442 2.078596736 1.055609892 0.175823828 1 0.224911298 0.459676913 4987 opioid related nociceptin receptor 1 "GO:0001626,GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0007186,GO:0007193,GO:0007218,GO:0007600,GO:0007610,GO:0019233,GO:0031410,GO:0038003,GO:0042277,GO:0042923,GO:0043005,GO:0051482" nociceptin receptor activity|G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|sensory perception|behavior|sensory perception of pain|cytoplasmic vesicle|opioid receptor signaling pathway|peptide binding|neuropeptide binding|neuron projection|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway hsa04080 Neuroactive ligand-receptor interaction OPTN 2693.940624 2632.247123 2755.634126 1.046875159 0.06608941 0.781078404 1 38.70989008 39.84630101 10133 optineurin "GO:0000086,GO:0000139,GO:0001920,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005776,GO:0005794,GO:0005802,GO:0005829,GO:0006914,GO:0007030,GO:0007165,GO:0008022,GO:0008219,GO:0010508,GO:0016032,GO:0030674,GO:0031267,GO:0031593,GO:0034067,GO:0034620,GO:0042802,GO:0043001,GO:0043122,GO:0043124,GO:0045087,GO:0046872,GO:0048471,GO:0050829,GO:0055038,GO:0061734,GO:0070530,GO:0090161,GO:1904417" G2/M transition of mitotic cell cycle|Golgi membrane|negative regulation of receptor recycling|protein binding|nucleus|nucleoplasm|cytoplasm|autophagosome|Golgi apparatus|trans-Golgi network|cytosol|autophagy|Golgi organization|signal transduction|protein C-terminus binding|cell death|positive regulation of autophagy|viral process|protein-macromolecule adaptor activity|small GTPase binding|polyubiquitin modification-dependent protein binding|protein localization to Golgi apparatus|cellular response to unfolded protein|identical protein binding|Golgi to plasma membrane protein transport|regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|metal ion binding|perinuclear region of cytoplasm|defense response to Gram-negative bacterium|recycling endosome membrane|parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization|K63-linked polyubiquitin modification-dependent protein binding|Golgi ribbon formation|positive regulation of xenophagy "hsa04137,hsa05014,hsa05022" Mitophagy - animal|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases OR10A3 3.522561699 4.161655531 2.883467868 0.692865579 -0.529352609 0.940314863 1 0.083811286 0.057098233 26496 olfactory receptor family 10 subfamily A member 3 "GO:0004930,GO:0004984,GO:0005886,GO:0007186,GO:0007608,GO:0016021,GO:0050911" G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|sensory perception of smell|integral component of membrane|detection of chemical stimulus involved in sensory perception of smell hsa04740 Olfactory transduction OR10A6 3.403674809 1.040413883 5.766935736 5.54292463 2.470647391 0.304382079 1 0.00909649 0.04957743 390093 olfactory receptor family 10 subfamily A member 6 (gene/pseudogene) "GO:0004930,GO:0004984,GO:0005886,GO:0007186,GO:0016021,GO:0050911" G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|detection of chemical stimulus involved in sensory perception of smell hsa04740 Olfactory transduction OR1J2 7.045123399 8.323311061 5.766935736 0.692865579 -0.529352609 0.780164403 1 0.224570179 0.152993243 26740 olfactory receptor family 1 subfamily J member 2 "GO:0004930,GO:0004984,GO:0005886,GO:0007186,GO:0016021,GO:0050911" G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|detection of chemical stimulus involved in sensory perception of smell hsa04740 Olfactory transduction OR2A7 22.77524895 30.1720026 15.3784953 0.509694219 -0.972296105 0.233216758 1 0.780904134 0.391361958 401427 olfactory receptor family 2 subfamily A member 7 "GO:0004930,GO:0004984,GO:0005549,GO:0005886,GO:0007186,GO:0016021,GO:0050911" G protein-coupled receptor activity|olfactory receptor activity|odorant binding|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|detection of chemical stimulus involved in sensory perception of smell hsa04740 Olfactory transduction OR2AG2 5.444873611 4.161655531 6.728091692 1.616686351 0.693039812 0.747994079 1 0.05258047 0.083583666 338755 olfactory receptor family 2 subfamily AG member 2 "GO:0004930,GO:0004984,GO:0005886,GO:0007186,GO:0016021,GO:0050911" G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|detection of chemical stimulus involved in sensory perception of smell hsa04740 Olfactory transduction OR2L13 5.003924597 5.202069413 4.80577978 0.923820772 -0.11431511 1 1 0.138951393 0.126218149 284521 olfactory receptor family 2 subfamily L member 13 "GO:0004930,GO:0004984,GO:0005515,GO:0005886,GO:0007186,GO:0008150,GO:0016021,GO:0050911" G protein-coupled receptor activity|olfactory receptor activity|protein binding|plasma membrane|G protein-coupled receptor signaling pathway|biological_process|integral component of membrane|detection of chemical stimulus involved in sensory perception of smell hsa04740 Olfactory transduction OR2M3 5.965080553 5.202069413 6.728091692 1.29334908 0.371111717 0.919461532 1 0.028006142 0.035615596 127062 olfactory receptor family 2 subfamily M member 3 "GO:0004930,GO:0004984,GO:0005886,GO:0007186,GO:0016021,GO:0050911" G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|detection of chemical stimulus involved in sensory perception of smell hsa04740 Olfactory transduction OR2M4 14.49156685 14.56579436 14.41733934 0.98980797 -0.014779436 1 1 0.130999271 0.127494369 26245 olfactory receptor family 2 subfamily M member 4 "GO:0004930,GO:0004984,GO:0005886,GO:0007186,GO:0007608,GO:0016021,GO:0050911" G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|sensory perception of smell|integral component of membrane|detection of chemical stimulus involved in sensory perception of smell hsa04740 Olfactory transduction OR51B2 3.081612685 5.202069413 0.961155956 0.184764154 -2.436243205 0.338470402 1 0.295660153 0.053713283 79345 olfactory receptor family 51 subfamily B member 2 "GO:0004930,GO:0004984,GO:0005886,GO:0007186,GO:0016021,GO:0050911" G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|detection of chemical stimulus involved in sensory perception of smell hsa04740 Olfactory transduction OR51B4 7.124381325 10.40413883 3.844623824 0.369528309 -1.436243205 0.311438224 1 0.595123009 0.216234823 79339 olfactory receptor family 51 subfamily B member 4 "GO:0004930,GO:0004984,GO:0005886,GO:0007186,GO:0007608,GO:0016021,GO:0050911" G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|sensory perception of smell|integral component of membrane|detection of chemical stimulus involved in sensory perception of smell hsa04740 Olfactory transduction OR51B5 85.21517316 117.5667687 52.86357758 0.449647278 -1.153134359 0.020297497 0.810058917 4.315214834 1.907855901 282763 olfactory receptor family 51 subfamily B member 5 "GO:0004930,GO:0004984,GO:0005886,GO:0007186,GO:0007608,GO:0016021,GO:0050911" G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|sensory perception of smell|integral component of membrane|detection of chemical stimulus involved in sensory perception of smell hsa04740 Olfactory transduction OR51E2 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.059661508 0.018064747 81285 olfactory receptor family 51 subfamily E member 2 "GO:0003707,GO:0004930,GO:0004984,GO:0005886,GO:0007186,GO:0016021,GO:0016477,GO:0030318,GO:0031901,GO:0038023,GO:0043229,GO:0043401,GO:0043950,GO:0045777,GO:0050911,GO:0071398,GO:0097325,GO:1900135" steroid hormone receptor activity|G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|cell migration|melanocyte differentiation|early endosome membrane|signaling receptor activity|intracellular organelle|steroid hormone mediated signaling pathway|positive regulation of cAMP-mediated signaling|positive regulation of blood pressure|detection of chemical stimulus involved in sensory perception of smell|cellular response to fatty acid|melanocyte proliferation|positive regulation of renin secretion into blood stream hsa04740 Olfactory transduction OR51M1 14.81362897 10.40413883 19.22311912 1.847641543 0.88568489 0.376416221 1 0.135691536 0.246514039 390059 olfactory receptor family 51 subfamily M member 1 "GO:0004930,GO:0004984,GO:0005886,GO:0007186,GO:0007608,GO:0016021,GO:0050911" G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|sensory perception of smell|integral component of membrane|detection of chemical stimulus involved in sensory perception of smell hsa04740 Olfactory transduction ORAI1 595.9822035 632.5716406 559.3927664 0.884315278 -0.17736728 0.502956849 1 22.52113799 19.58252269 84876 ORAI calcium release-activated calcium modulator 1 "GO:0002115,GO:0002250,GO:0005262,GO:0005515,GO:0005516,GO:0005829,GO:0005886,GO:0005887,GO:0015279,GO:0016020,GO:0016323,GO:0034704,GO:0042802,GO:0044853,GO:0045121,GO:0045762,GO:0051924,GO:0051928,GO:0061180,GO:0070509,GO:0070588" store-operated calcium entry|adaptive immune response|calcium channel activity|protein binding|calmodulin binding|cytosol|plasma membrane|integral component of plasma membrane|store-operated calcium channel activity|membrane|basolateral plasma membrane|calcium channel complex|identical protein binding|plasma membrane raft|membrane raft|positive regulation of adenylate cyclase activity|regulation of calcium ion transport|positive regulation of calcium ion transport|mammary gland epithelium development|calcium ion import|calcium ion transmembrane transport "hsa04020,hsa04024,hsa04611,hsa04924,hsa04925,hsa04927,hsa04934,hsa05340" Calcium signaling pathway|cAMP signaling pathway|Platelet activation|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome|Primary immunodeficiency ORAI2 1262.817575 1245.375418 1280.259733 1.028011084 0.03985582 0.871891042 1 6.171160365 6.237862654 80228 ORAI calcium release-activated calcium modulator 2 "GO:0002115,GO:0005515,GO:0015279,GO:0016020,GO:0016021,GO:0030426,GO:0070588" store-operated calcium entry|protein binding|store-operated calcium channel activity|membrane|integral component of membrane|growth cone|calcium ion transmembrane transport hsa04020 Calcium signaling pathway ORAI3 327.8265654 317.3262342 338.3268965 1.066180038 0.092451076 0.77096224 1 7.683810299 8.055237691 93129 ORAI calcium release-activated calcium modulator 3 "GO:0002115,GO:0005515,GO:0005886,GO:0015279,GO:0016020,GO:0016021,GO:0070588" store-operated calcium entry|protein binding|plasma membrane|store-operated calcium channel activity|membrane|integral component of membrane|calcium ion transmembrane transport hsa04020 Calcium signaling pathway ORC1 755.4831736 858.3414532 652.6248941 0.76033249 -0.395297655 0.118715882 1 14.40506471 10.76936114 4998 origin recognition complex subunit 1 "GO:0000082,GO:0000083,GO:0000781,GO:0000808,GO:0003677,GO:0003682,GO:0003688,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005664,GO:0005829,GO:0006260,GO:0006270,GO:0016887,GO:0033314,GO:0046872" "G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|chromosome, telomeric region|origin recognition complex|DNA binding|chromatin binding|DNA replication origin binding|protein binding|ATP binding|nucleus|nucleoplasm|nuclear origin of replication recognition complex|cytosol|DNA replication|DNA replication initiation|ATPase activity|mitotic DNA replication checkpoint|metal ion binding" hsa04110 Cell cycle other ORC2 1137.555914 1123.646993 1151.464835 1.024756745 0.035281486 0.888203879 1 13.40044131 13.50240297 4999 origin recognition complex subunit 2 "GO:0000082,GO:0000122,GO:0000781,GO:0000792,GO:0000808,GO:0000939,GO:0003688,GO:0005515,GO:0005634,GO:0005654,GO:0005664,GO:0005813,GO:0006260,GO:0006270,GO:0016020" "G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|chromosome, telomeric region|heterochromatin|origin recognition complex|condensed chromosome inner kinetochore|DNA replication origin binding|protein binding|nucleus|nucleoplasm|nuclear origin of replication recognition complex|centrosome|DNA replication|DNA replication initiation|membrane" hsa04110 Cell cycle ORC3 757.0544697 735.572615 778.5363244 1.058408522 0.081896583 0.750629769 1 11.22245813 11.67918399 23595 origin recognition complex subunit 3 "GO:0000082,GO:0000781,GO:0000785,GO:0000808,GO:0003688,GO:0005515,GO:0005654,GO:0005656,GO:0005664,GO:0006260,GO:0006267,GO:0006270,GO:0006275,GO:0016604,GO:0031261,GO:0061351" "G1/S transition of mitotic cell cycle|chromosome, telomeric region|chromatin|origin recognition complex|DNA replication origin binding|protein binding|nucleoplasm|nuclear pre-replicative complex|nuclear origin of replication recognition complex|DNA replication|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|DNA replication initiation|regulation of DNA replication|nuclear body|DNA replication preinitiation complex|neural precursor cell proliferation" hsa04110 Cell cycle ORC4 822.6508485 741.8150983 903.4865986 1.217940428 0.28444357 0.257117641 1 5.673446317 6.79429149 5000 origin recognition complex subunit 4 "GO:0000082,GO:0000166,GO:0000781,GO:0000808,GO:0003688,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005664,GO:0005730,GO:0005829,GO:0006260,GO:0006270" "G1/S transition of mitotic cell cycle|nucleotide binding|chromosome, telomeric region|origin recognition complex|DNA replication origin binding|protein binding|ATP binding|nucleus|nucleoplasm|nuclear origin of replication recognition complex|nucleolus|cytosol|DNA replication|DNA replication initiation" hsa04110 Cell cycle ORC5 488.9133084 483.7924554 494.0341614 1.021169627 0.030222533 0.920203955 1 6.533176663 6.559843369 5001 origin recognition complex subunit 5 "GO:0000082,GO:0000166,GO:0000781,GO:0000785,GO:0000808,GO:0003674,GO:0003688,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005664,GO:0005829,GO:0006260,GO:0006270,GO:0006275" "G1/S transition of mitotic cell cycle|nucleotide binding|chromosome, telomeric region|chromatin|origin recognition complex|molecular_function|DNA replication origin binding|protein binding|ATP binding|nucleus|nucleoplasm|nuclear origin of replication recognition complex|cytosol|DNA replication|DNA replication initiation|regulation of DNA replication" hsa04110 Cell cycle ORC6 953.0101691 934.2916666 971.7286715 1.040069933 0.056680537 0.822223466 1 28.26611627 28.9067896 23594 origin recognition complex subunit 6 "GO:0000082,GO:0000808,GO:0001650,GO:0003677,GO:0005515,GO:0005654,GO:0005664,GO:0006260,GO:0006270,GO:0016020,GO:0051782" G1/S transition of mitotic cell cycle|origin recognition complex|fibrillar center|DNA binding|protein binding|nucleoplasm|nuclear origin of replication recognition complex|DNA replication|DNA replication initiation|membrane|negative regulation of cell division hsa04110 Cell cycle ORMDL1 1250.104896 1189.193068 1311.016724 1.102442286 0.140703131 0.561406836 1 10.90090148 11.81651623 94101 ORMDL sphingolipid biosynthesis regulator 1 "GO:0005515,GO:0005783,GO:0005789,GO:0006672,GO:0016021,GO:0035339,GO:0090156,GO:1900060" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|ceramide metabolic process|integral component of membrane|SPOTS complex|cellular sphingolipid homeostasis|negative regulation of ceramide biosynthetic process ORMDL2 791.041528 769.9062732 812.1767828 1.054903449 0.077110961 0.763609641 1 20.35090776 21.10900081 29095 ORMDL sphingolipid biosynthesis regulator 2 "GO:0005515,GO:0005783,GO:0006672,GO:0016021,GO:0035339,GO:0090156,GO:1900060" protein binding|endoplasmic reticulum|ceramide metabolic process|integral component of membrane|SPOTS complex|cellular sphingolipid homeostasis|negative regulation of ceramide biosynthetic process ORMDL3 838.4847697 804.2399313 872.729608 1.085160751 0.117908773 0.640376219 1 11.53475061 12.30760261 94103 ORMDL sphingolipid biosynthesis regulator 3 "GO:0002903,GO:0005515,GO:0005783,GO:0005886,GO:0006672,GO:0006686,GO:0006940,GO:0010508,GO:0016021,GO:0030667,GO:0035339,GO:0035579,GO:0042552,GO:0043312,GO:0061744,GO:0090156,GO:1900060,GO:1900182,GO:1904221" negative regulation of B cell apoptotic process|protein binding|endoplasmic reticulum|plasma membrane|ceramide metabolic process|sphingomyelin biosynthetic process|regulation of smooth muscle contraction|positive regulation of autophagy|integral component of membrane|secretory granule membrane|SPOTS complex|specific granule membrane|myelination|neutrophil degranulation|motor behavior|cellular sphingolipid homeostasis|negative regulation of ceramide biosynthetic process|positive regulation of protein localization to nucleus|negative regulation of serine C-palmitoyltransferase activity OS9 3337.894494 3577.983342 3097.805646 0.865796553 -0.207900037 0.380742575 1 72.32969505 61.57489292 10956 OS9 endoplasmic reticulum lectin "GO:0000836,GO:0002020,GO:0005515,GO:0005783,GO:0005788,GO:0005789,GO:0006511,GO:0006605,GO:0006621,GO:0016567,GO:0030246,GO:0030433,GO:0030970,GO:0034976,GO:0044322,GO:0055085,GO:1904153,GO:1904380" "Hrd1p ubiquitin ligase complex|protease binding|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|ubiquitin-dependent protein catabolic process|protein targeting|protein retention in ER lumen|protein ubiquitination|carbohydrate binding|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|response to endoplasmic reticulum stress|endoplasmic reticulum quality control compartment|transmembrane transport|negative regulation of retrograde protein transport, ER to cytosol|endoplasmic reticulum mannose trimming" hsa04141 Protein processing in endoplasmic reticulum OSBP 2428.801204 2484.508352 2373.094055 0.955156401 -0.06619111 0.780773069 1 28.13359737 26.42231932 5007 oxysterol binding protein "GO:0000139,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005789,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0006699,GO:0008142,GO:0015248,GO:0015918,GO:0016020,GO:0019904,GO:0030054,GO:0032367,GO:0032934,GO:0043231,GO:0048471,GO:0070273,GO:0097038,GO:0120009,GO:0120015" Golgi membrane|protein binding|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|bile acid biosynthetic process|oxysterol binding|sterol transporter activity|sterol transport|membrane|protein domain specific binding|cell junction|intracellular cholesterol transport|sterol binding|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|phosphatidylinositol-4-phosphate binding|perinuclear endoplasmic reticulum|intermembrane lipid transfer|sterol transfer activity OSBP2 335.5453811 343.3365813 327.754181 0.954614797 -0.067009395 0.834563372 1 3.559293379 3.340897315 23762 oxysterol binding protein 2 "GO:0005515,GO:0005829,GO:0005886,GO:0007286,GO:0015248,GO:0015485,GO:0015918,GO:0016020,GO:0032934,GO:0043231,GO:0097038,GO:0097440" protein binding|cytosol|plasma membrane|spermatid development|sterol transporter activity|cholesterol binding|sterol transport|membrane|sterol binding|intracellular membrane-bounded organelle|perinuclear endoplasmic reticulum|apical dendrite OSBPL10 836.874459 825.0482089 848.7007091 1.028668022 0.040777462 0.875238884 1 6.752232255 6.829576751 114884 oxysterol binding protein like 10 "GO:0001786,GO:0005515,GO:0005548,GO:0005829,GO:0005856,GO:0015248,GO:0015485,GO:0015914,GO:0015918,GO:0016020,GO:0032934,GO:0036150,GO:0043231" phosphatidylserine binding|protein binding|phospholipid transporter activity|cytosol|cytoskeleton|sterol transporter activity|cholesterol binding|phospholipid transport|sterol transport|membrane|sterol binding|phosphatidylserine acyl-chain remodeling|intracellular membrane-bounded organelle OSBPL11 556.1193834 570.1468077 542.0919592 0.950793641 -0.07279584 0.790788756 1 6.617591831 6.186676732 114885 oxysterol binding protein like 11 "GO:0005515,GO:0005654,GO:0005794,GO:0005829,GO:0010890,GO:0015248,GO:0015918,GO:0016020,GO:0031902,GO:0032934,GO:0043231,GO:0045444" protein binding|nucleoplasm|Golgi apparatus|cytosol|positive regulation of sequestering of triglyceride|sterol transporter activity|sterol transport|membrane|late endosome membrane|sterol binding|intracellular membrane-bounded organelle|fat cell differentiation OSBPL1A 1432.812003 1469.064402 1396.559604 0.950645596 -0.073020496 0.762391609 1 13.43868137 12.56164385 114876 oxysterol binding protein like 1A "GO:0005515,GO:0005543,GO:0005768,GO:0005770,GO:0005829,GO:0006699,GO:0008203,GO:0015248,GO:0015485,GO:0015918,GO:0016020,GO:0016192,GO:0019886,GO:0032934,GO:0043231,GO:0044232,GO:0070062" protein binding|phospholipid binding|endosome|late endosome|cytosol|bile acid biosynthetic process|cholesterol metabolic process|sterol transporter activity|cholesterol binding|sterol transport|membrane|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|sterol binding|intracellular membrane-bounded organelle|organelle membrane contact site|extracellular exosome OSBPL2 1740.588886 1651.136832 1830.04094 1.108352079 0.148416241 0.532604293 1 21.84386169 23.80555641 9885 oxysterol binding protein like 2 "GO:0005515,GO:0005546,GO:0005811,GO:0005829,GO:0006699,GO:0007009,GO:0008526,GO:0015248,GO:0015485,GO:0015914,GO:0016020,GO:0030301,GO:0031234,GO:0032367,GO:0032934,GO:0043231,GO:0051289,GO:0120009,GO:0120020" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|lipid droplet|cytosol|bile acid biosynthetic process|plasma membrane organization|phosphatidylinositol transfer activity|sterol transporter activity|cholesterol binding|phospholipid transport|membrane|cholesterol transport|extrinsic component of cytoplasmic side of plasma membrane|intracellular cholesterol transport|sterol binding|intracellular membrane-bounded organelle|protein homotetramerization|intermembrane lipid transfer|cholesterol transfer activity" OSBPL3 1730.986158 1828.007192 1633.965125 0.893850491 -0.161894555 0.495892285 1 13.51771984 11.88063087 26031 oxysterol binding protein like 3 "GO:0005515,GO:0005789,GO:0005829,GO:0005886,GO:0006699,GO:0015248,GO:0015485,GO:0015918,GO:0016020,GO:0031965,GO:0032433,GO:0032934,GO:0043231,GO:0097038" protein binding|endoplasmic reticulum membrane|cytosol|plasma membrane|bile acid biosynthetic process|sterol transporter activity|cholesterol binding|sterol transport|membrane|nuclear membrane|filopodium tip|sterol binding|intracellular membrane-bounded organelle|perinuclear endoplasmic reticulum OSBPL5 759.9825969 724.1280623 795.8371316 1.099028159 0.136228352 0.593421523 1 7.03154727 7.598553041 114879 oxysterol binding protein like 5 "GO:0001786,GO:0005548,GO:0005789,GO:0005829,GO:0006893,GO:0008142,GO:0008203,GO:0015248,GO:0015485,GO:0015914,GO:0016020,GO:0016021,GO:0030301,GO:0032934,GO:0036150,GO:0043231,GO:0070273,GO:0120009,GO:0140268,GO:0140343" phosphatidylserine binding|phospholipid transporter activity|endoplasmic reticulum membrane|cytosol|Golgi to plasma membrane transport|oxysterol binding|cholesterol metabolic process|sterol transporter activity|cholesterol binding|phospholipid transport|membrane|integral component of membrane|cholesterol transport|sterol binding|phosphatidylserine acyl-chain remodeling|intracellular membrane-bounded organelle|phosphatidylinositol-4-phosphate binding|intermembrane lipid transfer|endoplasmic reticulum-plasma membrane contact site|phosphatidylserine transfer activity hsa04979 Cholesterol metabolism OSBPL6 731.1378574 749.0979955 713.1777193 0.952048629 -0.07089283 0.785125165 1 3.547292213 3.320681907 114880 oxysterol binding protein like 6 "GO:0005515,GO:0005789,GO:0005829,GO:0005886,GO:0006699,GO:0015248,GO:0015485,GO:0015918,GO:0016020,GO:0031901,GO:0031965,GO:0032374,GO:0032934,GO:0043231,GO:0097038" protein binding|endoplasmic reticulum membrane|cytosol|plasma membrane|bile acid biosynthetic process|sterol transporter activity|cholesterol binding|sterol transport|membrane|early endosome membrane|nuclear membrane|regulation of cholesterol transport|sterol binding|intracellular membrane-bounded organelle|perinuclear endoplasmic reticulum OSBPL7 198.234672 208.0827765 188.3865674 0.905344356 -0.143461456 0.703824739 1 2.733200921 2.433080823 114881 oxysterol binding protein like 7 "GO:0005515,GO:0005654,GO:0005776,GO:0005789,GO:0005829,GO:0005886,GO:0006699,GO:0010506,GO:0015248,GO:0015485,GO:0015918,GO:0016020,GO:0032934,GO:0043231,GO:0071397,GO:0097038,GO:1901800" protein binding|nucleoplasm|autophagosome|endoplasmic reticulum membrane|cytosol|plasma membrane|bile acid biosynthetic process|regulation of autophagy|sterol transporter activity|cholesterol binding|sterol transport|membrane|sterol binding|intracellular membrane-bounded organelle|cellular response to cholesterol|perinuclear endoplasmic reticulum|positive regulation of proteasomal protein catabolic process OSBPL8 2763.876068 2802.875 2724.877135 0.972172193 -0.040716226 0.864711193 1 18.26425974 17.45888274 114882 oxysterol binding protein like 8 "GO:0001786,GO:0005515,GO:0005548,GO:0005789,GO:0005829,GO:0010891,GO:0015248,GO:0015485,GO:0015914,GO:0015918,GO:0016020,GO:0016021,GO:0030336,GO:0031965,GO:0032148,GO:0032934,GO:0036150,GO:0043231,GO:0045444,GO:0046326,GO:0046628,GO:0051897,GO:0070273,GO:0090204,GO:0120009,GO:0140343" phosphatidylserine binding|protein binding|phospholipid transporter activity|endoplasmic reticulum membrane|cytosol|negative regulation of sequestering of triglyceride|sterol transporter activity|cholesterol binding|phospholipid transport|sterol transport|membrane|integral component of membrane|negative regulation of cell migration|nuclear membrane|activation of protein kinase B activity|sterol binding|phosphatidylserine acyl-chain remodeling|intracellular membrane-bounded organelle|fat cell differentiation|positive regulation of glucose import|positive regulation of insulin receptor signaling pathway|positive regulation of protein kinase B signaling|phosphatidylinositol-4-phosphate binding|protein localization to nuclear pore|intermembrane lipid transfer|phosphatidylserine transfer activity OSBPL9 2640.462491 2666.580781 2614.3442 0.980410651 -0.028541937 0.905495065 1 38.17342149 36.79936181 114883 oxysterol binding protein like 9 "GO:0005515,GO:0005794,GO:0005829,GO:0006699,GO:0015248,GO:0015918,GO:0016020,GO:0031902,GO:0032934,GO:0043231" protein binding|Golgi apparatus|cytosol|bile acid biosynthetic process|sterol transporter activity|sterol transport|membrane|late endosome membrane|sterol binding|intracellular membrane-bounded organelle OSCAR 1840.542846 1865.462092 1815.623601 0.973283568 -0.039067896 0.871201711 1 48.11806827 46.0488463 126014 osteoclast associated Ig-like receptor "GO:0005576,GO:0005886,GO:0016021,GO:0030316,GO:0035580,GO:0038064,GO:0038065,GO:0043312,GO:0050776,GO:0070062,GO:1904724" extracellular region|plasma membrane|integral component of membrane|osteoclast differentiation|specific granule lumen|collagen receptor activity|collagen-activated signaling pathway|neutrophil degranulation|regulation of immune response|extracellular exosome|tertiary granule lumen hsa04380 Osteoclast differentiation OSCP1 71.58096663 62.42483296 80.7371003 1.29334908 0.371111717 0.491308042 1 1.917961199 2.439083983 127700 organic solute carrier partner 1 "GO:0005737,GO:0009925,GO:0022857,GO:1990961" cytoplasm|basal plasma membrane|transmembrane transporter activity|xenobiotic detoxification by transmembrane export across the plasma membrane OSER1 1212.882125 1233.930865 1191.833385 0.965883438 -0.050078999 0.839074263 1 10.46276174 9.93670126 51526 oxidative stress responsive serine rich 1 GO:0070301 cellular response to hydrogen peroxide OSGEP 354.8773263 371.4277561 338.3268965 0.910882105 -0.134663755 0.658567836 1 10.03158739 8.984688194 55644 O-sialoglycoprotein endopeptidase "GO:0000408,GO:0002949,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0016607,GO:0046872,GO:0061711" EKC/KEOPS complex|tRNA threonylcarbamoyladenosine modification|protein binding|nucleus|nucleoplasm|cytoplasm|plasma membrane|nuclear speck|metal ion binding|N(6)-L-threonylcarbamoyladenine synthase activity OSGEPL1 282.0232024 288.1946455 275.8517594 0.957171702 -0.063150349 0.854945071 1 4.123436609 3.880791868 64172 O-sialoglycoprotein endopeptidase like 1 "GO:0000408,GO:0002949,GO:0005739,GO:0046872,GO:0061711" EKC/KEOPS complex|tRNA threonylcarbamoyladenosine modification|mitochondrion|metal ion binding|N(6)-L-threonylcarbamoyladenine synthase activity OSGIN1 309.5199428 328.7707869 290.2690987 0.882892003 -0.179691119 0.569292401 1 9.128976401 7.925028748 29948 oxidative stress induced growth inhibitor 1 "GO:0005515,GO:0005575,GO:0007165,GO:0007275,GO:0008083,GO:0030154,GO:0030308,GO:0030334,GO:0042127,GO:0042981,GO:0043065" protein binding|cellular_component|signal transduction|multicellular organism development|growth factor activity|cell differentiation|negative regulation of cell growth|regulation of cell migration|regulation of cell population proliferation|regulation of apoptotic process|positive regulation of apoptotic process OSGIN2 1689.598545 1574.146204 1805.050885 1.146685664 0.197469966 0.406259236 1 6.535145062 7.368359276 734 oxidative stress induced growth inhibitor family member 2 "GO:0003674,GO:0005575,GO:0007165,GO:0008083,GO:0030308,GO:0051321" molecular_function|cellular_component|signal transduction|growth factor activity|negative regulation of cell growth|meiotic cell cycle OSMR 4351.20904 4631.922606 4070.495474 0.878791772 -0.186406733 0.435107771 1 38.61852778 33.36974394 9180 oncostatin M receptor "GO:0002675,GO:0004896,GO:0004923,GO:0004924,GO:0005127,GO:0005515,GO:0005886,GO:0005900,GO:0008284,GO:0009897,GO:0016324,GO:0019221,GO:0019838,GO:0019955,GO:0034097,GO:0038165,GO:0043235,GO:0048861" positive regulation of acute inflammatory response|cytokine receptor activity|leukemia inhibitory factor receptor activity|oncostatin-M receptor activity|ciliary neurotrophic factor receptor binding|protein binding|plasma membrane|oncostatin-M receptor complex|positive regulation of cell population proliferation|external side of plasma membrane|apical plasma membrane|cytokine-mediated signaling pathway|growth factor binding|cytokine binding|response to cytokine|oncostatin-M-mediated signaling pathway|receptor complex|leukemia inhibitory factor signaling pathway "hsa04060,hsa04151,hsa04630" Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|JAK-STAT signaling pathway OSR1 59.12556817 63.46524684 54.78588949 0.86324236 -0.212162433 0.72880657 1 1.111592904 0.94351691 130497 odd-skipped related transcription factor 1 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001655,GO:0001657,GO:0001823,GO:0002062,GO:0005634,GO:0005829,GO:0006357,GO:0007507,GO:0008406,GO:0009790,GO:0010628,GO:0019898,GO:0030154,GO:0030501,GO:0030857,GO:0035115,GO:0035116,GO:0036023,GO:0042474,GO:0042476,GO:0042733,GO:0043066,GO:0045944,GO:0046872,GO:0048389,GO:0048793,GO:0048863,GO:0050679,GO:0060021,GO:0060272,GO:0071300,GO:0072075,GO:0072111,GO:0072133,GO:0072143,GO:0072162,GO:0072166,GO:0072168,GO:0072169,GO:0072180,GO:0072183,GO:0072184,GO:0072190,GO:0072207,GO:0072208,GO:0072234,GO:0072239,GO:0072259,GO:0072268,GO:0072498,GO:0090094,GO:1905408,GO:1990837,GO:2000543,GO:2000650" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|urogenital system development|ureteric bud development|mesonephros development|chondrocyte differentiation|nucleus|cytosol|regulation of transcription by RNA polymerase II|heart development|gonad development|embryo development|positive regulation of gene expression|extrinsic component of membrane|cell differentiation|positive regulation of bone mineralization|negative regulation of epithelial cell differentiation|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic skeletal limb joint morphogenesis|middle ear morphogenesis|odontogenesis|embryonic digit morphogenesis|negative regulation of apoptotic process|positive regulation of transcription by RNA polymerase II|metal ion binding|intermediate mesoderm development|pronephros development|stem cell differentiation|positive regulation of epithelial cell proliferation|roof of mouth development|embryonic skeletal joint morphogenesis|cellular response to retinoic acid|metanephric mesenchyme development|cell proliferation involved in kidney development|metanephric mesenchyme morphogenesis|mesangial cell development|metanephric mesenchymal cell differentiation|posterior mesonephric tubule development|specification of anterior mesonephric tubule identity|specification of posterior mesonephric tubule identity|mesonephric duct morphogenesis|negative regulation of nephron tubule epithelial cell differentiation|renal vesicle progenitor cell differentiation|ureter urothelium development|metanephric epithelium development|metanephric smooth muscle tissue development|metanephric nephron tubule development|metanephric glomerulus vasculature development|metanephric interstitial fibroblast development|pattern specification involved in metanephros development|embryonic skeletal joint development|metanephric cap mesenchymal cell proliferation involved in metanephros development|negative regulation of creatine transmembrane transporter activity|sequence-specific double-stranded DNA binding|positive regulation of gastrulation|negative regulation of sodium ion transmembrane transporter activity" OSR2 61.33031324 58.26317743 64.39744905 1.105285566 0.144419158 0.821516307 1 1.476447624 1.604588674 116039 odd-skipped related transciption factor 2 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0001228,GO:0001655,GO:0001656,GO:0001823,GO:0002062,GO:0005515,GO:0005634,GO:0006357,GO:0008284,GO:0009790,GO:0009792,GO:0010628,GO:0030154,GO:0030501,GO:0033687,GO:0035115,GO:0035116,GO:0036023,GO:0042474,GO:0042476,GO:0042733,GO:0043565,GO:0045893,GO:0045944,GO:0046872,GO:0048704,GO:0050679,GO:0060021,GO:0060272,GO:0060322,GO:0060349,GO:0061029,GO:0072498,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|urogenital system development|metanephros development|mesonephros development|chondrocyte differentiation|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of cell population proliferation|embryo development|embryo development ending in birth or egg hatching|positive regulation of gene expression|cell differentiation|positive regulation of bone mineralization|osteoblast proliferation|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic skeletal limb joint morphogenesis|middle ear morphogenesis|odontogenesis|embryonic digit morphogenesis|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|embryonic skeletal system morphogenesis|positive regulation of epithelial cell proliferation|roof of mouth development|embryonic skeletal joint morphogenesis|head development|bone morphogenesis|eyelid development in camera-type eye|embryonic skeletal joint development|sequence-specific double-stranded DNA binding" zf-C2H2 OST4 1286.000404 1059.141333 1512.859475 1.428383001 0.51438287 0.032848378 0.920517339 127.8833174 179.6096826 100128731 "oligosaccharyltransferase complex subunit 4, non-catalytic" "GO:0005515,GO:0008250,GO:0016021,GO:0018279" protein binding|oligosaccharyltransferase complex|integral component of membrane|protein N-linked glycosylation via asparagine OSTC 1291.429572 1201.678034 1381.181109 1.149377012 0.2008521 0.40488655 1 56.4536515 63.80074109 58505 oligosaccharyltransferase complex non-catalytic subunit "GO:0004579,GO:0005515,GO:0008250,GO:0016021,GO:0018279" dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding|oligosaccharyltransferase complex|integral component of membrane|protein N-linked glycosylation via asparagine OSTF1 882.1481686 777.1891703 987.1071668 1.270098973 0.344940924 0.165802308 1 30.65569668 38.2842315 26578 osteoclast stimulating factor 1 "GO:0001503,GO:0005515,GO:0005576,GO:0005622,GO:0007165,GO:0017124,GO:0034774,GO:0043312,GO:1904813" ossification|protein binding|extracellular region|intracellular anatomical structure|signal transduction|SH3 domain binding|secretory granule lumen|neutrophil degranulation|ficolin-1-rich granule lumen OSTM1 815.6346788 860.4222809 770.8470767 0.895893904 -0.158600203 0.529529846 1 10.27044414 9.047258205 28962 osteoclastogenesis associated transmembrane protein 1 "GO:0005765,GO:0005829,GO:0016021,GO:0030316,GO:0034220" lysosomal membrane|cytosol|integral component of membrane|osteoclast differentiation|ion transmembrane transport OTOGL 4.483717655 4.161655531 4.80577978 1.154775965 0.207612985 1 1 0.023227349 0.026373548 283310 otogelin like "GO:0005515,GO:0005615,GO:0007605,GO:0031012,GO:0046373,GO:0046556" protein binding|extracellular space|sensory perception of sound|extracellular matrix|L-arabinose metabolic process|alpha-L-arabinofuranosidase activity OTUB1 1640.019755 1572.065377 1707.974134 1.086452357 0.119624911 0.61619074 1 49.32289231 52.69026719 55611 "OTU deubiquitinase, ubiquitin aldehyde binding 1" "GO:0002250,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006974,GO:0016579,GO:0018215,GO:0019784,GO:0031625,GO:0043130,GO:0070062,GO:0071108,GO:1901315,GO:2000780" adaptive immune response|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytosol|DNA repair|cellular response to DNA damage stimulus|protein deubiquitination|protein phosphopantetheinylation|NEDD8-specific protease activity|ubiquitin protein ligase binding|ubiquitin binding|extracellular exosome|protein K48-linked deubiquitination|negative regulation of histone H2A K63-linked ubiquitination|negative regulation of double-strand break repair OTUB2 403.162837 402.6401726 403.6855015 1.002596186 0.003740652 0.999589956 1 5.494289437 5.416375452 78990 "OTU deubiquitinase, ubiquitin aldehyde binding 2" "GO:0004843,GO:0005515,GO:0005634,GO:0016579,GO:0018215,GO:0019784,GO:0035871,GO:0043130,GO:0070536,GO:0071108,GO:1901315,GO:2000780" thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|protein deubiquitination|protein phosphopantetheinylation|NEDD8-specific protease activity|protein K11-linked deubiquitination|ubiquitin binding|protein K63-linked deubiquitination|protein K48-linked deubiquitination|negative regulation of histone H2A K63-linked ubiquitination|negative regulation of double-strand break repair OTUD1 136.6615545 156.0620824 117.2610266 0.751374228 -0.412396463 0.328263881 1 2.521570241 1.86293861 220213 OTU deubiquitinase 1 "GO:0004843,GO:0008234,GO:0016579,GO:0018215,GO:0070536" thiol-dependent ubiquitin-specific protease activity|cysteine-type peptidase activity|protein deubiquitination|protein phosphopantetheinylation|protein K63-linked deubiquitination OTUD3 339.1472008 349.5790646 328.7153369 0.940317571 -0.088780018 0.77766208 1 2.642174221 2.442908391 23252 OTU deubiquitinase 3 "GO:0004843,GO:0005515,GO:0005737,GO:0005829,GO:0008234,GO:0016579,GO:0018215,GO:0035871,GO:0044313,GO:0050821,GO:0051898,GO:0071108,GO:1990167" thiol-dependent ubiquitin-specific protease activity|protein binding|cytoplasm|cytosol|cysteine-type peptidase activity|protein deubiquitination|protein phosphopantetheinylation|protein K11-linked deubiquitination|protein K6-linked deubiquitination|protein stabilization|negative regulation of protein kinase B signaling|protein K48-linked deubiquitination|protein K27-linked deubiquitination OTUD4 1970.78831 2042.332452 1899.244169 0.92993879 -0.104792336 0.659119741 1 13.19398733 12.06428546 54726 OTU deubiquitinase 4 "GO:0003723,GO:0004843,GO:0005515,GO:0005634,GO:0005829,GO:0008234,GO:0016579,GO:0018215,GO:0034122,GO:0045087,GO:0060090,GO:0061578,GO:0070536,GO:0071108,GO:1901537,GO:1903093,GO:2000660" RNA binding|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytosol|cysteine-type peptidase activity|protein deubiquitination|protein phosphopantetheinylation|negative regulation of toll-like receptor signaling pathway|innate immune response|molecular adaptor activity|Lys63-specific deubiquitinase activity|protein K63-linked deubiquitination|protein K48-linked deubiquitination|positive regulation of DNA demethylation|regulation of protein K48-linked deubiquitination|negative regulation of interleukin-1-mediated signaling pathway OTUD5 1745.022914 1679.228007 1810.817821 1.07836328 0.108843276 0.647811748 1 14.17098552 15.02575571 55593 OTU deubiquitinase 5 "GO:0004843,GO:0005829,GO:0008234,GO:0016579,GO:0018215,GO:0032480,GO:0032496,GO:0061578,GO:0070536,GO:0071108,GO:0101005,GO:1990380" thiol-dependent ubiquitin-specific protease activity|cytosol|cysteine-type peptidase activity|protein deubiquitination|protein phosphopantetheinylation|negative regulation of type I interferon production|response to lipopolysaccharide|Lys63-specific deubiquitinase activity|protein K63-linked deubiquitination|protein K48-linked deubiquitination|ubiquitinyl hydrolase activity|Lys48-specific deubiquitinase activity hsa04622 RIG-I-like receptor signaling pathway OTUD6B 693.7225866 675.2286098 712.2165634 1.054778416 0.076939954 0.76883324 1 10.83129242 11.23343803 51633 OTU deubiquitinase 6B "GO:0004843,GO:0008234,GO:0008283,GO:0016281,GO:0016579,GO:0018215,GO:0043248" thiol-dependent ubiquitin-specific protease activity|cysteine-type peptidase activity|cell population proliferation|eukaryotic translation initiation factor 4F complex|protein deubiquitination|protein phosphopantetheinylation|proteasome assembly OTUD7B 856.2208811 916.6046306 795.8371316 0.868244721 -0.203826361 0.415340589 1 3.885116709 3.316785602 56957 OTU deubiquitinase 7B "GO:0000122,GO:0001701,GO:0002250,GO:0002385,GO:0003677,GO:0004843,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0008234,GO:0008270,GO:0016579,GO:0018215,GO:0032717,GO:0035871,GO:0043124,GO:0070530,GO:0070536,GO:0071108,GO:0071947,GO:1900181,GO:1990380" negative regulation of transcription by RNA polymerase II|in utero embryonic development|adaptive immune response|mucosal immune response|DNA binding|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytoplasm|cytosol|cysteine-type peptidase activity|zinc ion binding|protein deubiquitination|protein phosphopantetheinylation|negative regulation of interleukin-8 production|protein K11-linked deubiquitination|negative regulation of I-kappaB kinase/NF-kappaB signaling|K63-linked polyubiquitin modification-dependent protein binding|protein K63-linked deubiquitination|protein K48-linked deubiquitination|protein deubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of protein localization to nucleus|Lys48-specific deubiquitinase activity OTULIN 1083.344952 1088.272921 1078.416983 0.990943505 -0.013125286 0.961263958 1 3.689437533 3.594845546 90268 OTU deubiquitinase with linear linkage specificity "GO:0002040,GO:0004843,GO:0005515,GO:0005737,GO:0005829,GO:0008234,GO:0010803,GO:0016055,GO:0016567,GO:0018215,GO:0032088,GO:0045087,GO:0050728,GO:0060828,GO:0070431,GO:0071797,GO:1990108" sprouting angiogenesis|thiol-dependent ubiquitin-specific protease activity|protein binding|cytoplasm|cytosol|cysteine-type peptidase activity|regulation of tumor necrosis factor-mediated signaling pathway|Wnt signaling pathway|protein ubiquitination|protein phosphopantetheinylation|negative regulation of NF-kappaB transcription factor activity|innate immune response|negative regulation of inflammatory response|regulation of canonical Wnt signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|LUBAC complex|protein linear deubiquitination OTULINL 313.4293477 267.3863678 359.4723275 1.344392874 0.426954801 0.169326536 1 5.155317564 6.81479511 54491 OTU deubiquitinase with linear linkage specificity like "GO:0005515,GO:0005635,GO:0005737,GO:0016579,GO:0019783,GO:0042406,GO:0043130" protein binding|nuclear envelope|cytoplasm|protein deubiquitination|ubiquitin-like protein-specific protease activity|extrinsic component of endoplasmic reticulum membrane|ubiquitin binding OTX1 62.84627468 72.82897178 52.86357758 0.725859178 -0.462238413 0.40919901 1 1.197396294 0.85459719 5013 orthodenticle homeobox 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0009952,GO:0022037,GO:0030901,GO:0042472,GO:0045944,GO:0048852,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|metencephalon development|midbrain development|inner ear morphogenesis|positive regulation of transcription by RNA polymerase II|diencephalon morphogenesis|sequence-specific double-stranded DNA binding" hsa04550 Signaling pathways regulating pluripotency of stem cells OVCA2 9.007064274 9.363724944 8.650403604 0.923820772 -0.11431511 1 1 0.484699118 0.440282203 124641 OVCA2 serine hydrolase domain containing "GO:0005634,GO:0005737,GO:0016787,GO:0032526" nucleus|cytoplasm|hydrolase activity|response to retinoic acid OVGP1 17.96946917 30.1720026 5.766935736 0.191135332 -2.387333604 0.011238978 0.629889443 0.733253336 0.137805389 5016 oviductal glycoprotein 1 "GO:0004568,GO:0005576,GO:0005829,GO:0005975,GO:0006032,GO:0007339,GO:0007565,GO:0008061,GO:0015630,GO:0030133,GO:0035805,GO:0043231,GO:0098595,GO:2000360" chitinase activity|extracellular region|cytosol|carbohydrate metabolic process|chitin catabolic process|binding of sperm to zona pellucida|female pregnancy|chitin binding|microtubule cytoskeleton|transport vesicle|egg coat|intracellular membrane-bounded organelle|perivitelline space|negative regulation of binding of sperm to zona pellucida OVOL2 5.003924597 5.202069413 4.80577978 0.923820772 -0.11431511 1 1 0.146658681 0.133219156 58495 ovo like zinc finger 2 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0001525,GO:0001755,GO:0001842,GO:0001947,GO:0003682,GO:0005515,GO:0005634,GO:0006357,GO:0009913,GO:0009953,GO:0010628,GO:0010629,GO:0010719,GO:0010837,GO:0045618,GO:0045944,GO:0046872,GO:0048557,GO:0060214,GO:0060347,GO:0060390,GO:0060716,GO:0071560,GO:1990837,GO:2000647" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|neural crest cell migration|neural fold formation|heart looping|chromatin binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|epidermal cell differentiation|dorsal/ventral pattern formation|positive regulation of gene expression|negative regulation of gene expression|negative regulation of epithelial to mesenchymal transition|regulation of keratinocyte proliferation|positive regulation of keratinocyte differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|embryonic digestive tract morphogenesis|endocardium formation|heart trabecula formation|regulation of SMAD protein signal transduction|labyrinthine layer blood vessel development|cellular response to transforming growth factor beta stimulus|sequence-specific double-stranded DNA binding|negative regulation of stem cell proliferation" zf-C2H2 OXA1L 3667.058998 3854.733435 3479.384561 0.902626503 -0.147798955 0.534220371 1 73.31434025 65.06810975 5018 OXA1L mitochondrial inner membrane protein "GO:0005515,GO:0005739,GO:0005746,GO:0005759,GO:0009060,GO:0031305,GO:0031966,GO:0032592,GO:0032780,GO:0032977,GO:0032979,GO:0032981,GO:0032991,GO:0033615,GO:0033617,GO:0042803,GO:0051205,GO:0051262,GO:0051354,GO:0055114,GO:0065003,GO:0070125,GO:0070126,GO:0097177" protein binding|mitochondrion|mitochondrial respirasome|mitochondrial matrix|aerobic respiration|integral component of mitochondrial inner membrane|mitochondrial membrane|integral component of mitochondrial membrane|negative regulation of ATPase activity|membrane insertase activity|protein insertion into mitochondrial inner membrane from matrix|mitochondrial respiratory chain complex I assembly|protein-containing complex|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial cytochrome c oxidase assembly|protein homodimerization activity|protein insertion into membrane|protein tetramerization|negative regulation of oxidoreductase activity|oxidation-reduction process|protein-containing complex assembly|mitochondrial translational elongation|mitochondrial translational termination|mitochondrial ribosome binding hsa03060 Protein export OXCT1 1019.309808 984.231533 1054.388084 1.071280536 0.099336327 0.688307372 1 13.02097867 13.71570136 5019 3-oxoacid CoA-transferase 1 "GO:0005739,GO:0005759,GO:0007420,GO:0007507,GO:0007584,GO:0008260,GO:0008410,GO:0009725,GO:0014823,GO:0035774,GO:0042182,GO:0042493,GO:0042594,GO:0042802,GO:0045471,GO:0046950,GO:0046952,GO:0060612" mitochondrion|mitochondrial matrix|brain development|heart development|response to nutrient|3-oxoacid CoA-transferase activity|CoA-transferase activity|response to hormone|response to activity|positive regulation of insulin secretion involved in cellular response to glucose stimulus|ketone catabolic process|response to drug|response to starvation|identical protein binding|response to ethanol|cellular ketone body metabolic process|ketone body catabolic process|adipose tissue development "hsa00072,hsa00280,hsa00650" "Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Butanoate metabolism" OXCT2 11.00863411 11.44455271 10.57271552 0.923820772 -0.11431511 1 1 0.334487812 0.303835978 64064 3-oxoacid CoA-transferase 2 "GO:0005739,GO:0005759,GO:0008260,GO:0008410,GO:0031514,GO:0046950,GO:0046952" mitochondrion|mitochondrial matrix|3-oxoacid CoA-transferase activity|CoA-transferase activity|motile cilium|cellular ketone body metabolic process|ketone body catabolic process "hsa00072,hsa00280,hsa00650" "Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Butanoate metabolism" OXER1 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.094483795 0.028608493 165140 oxoeicosanoid receptor 1 "GO:0004930,GO:0005515,GO:0005886,GO:0007186,GO:0007193,GO:0016021,GO:0050646,GO:0050647,GO:0050648" "G protein-coupled receptor activity|protein binding|plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|integral component of membrane|5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding" OXGR1 9.566900179 11.44455271 7.689247648 0.671869652 -0.573746729 0.681462136 1 0.235456725 0.155549028 27199 oxoglutarate receptor 1 "GO:0004930,GO:0005886,GO:0007186,GO:0016021" G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane OXLD1 385.11411 370.3873422 399.8408777 1.079520902 0.110391177 0.712155249 1 12.59037689 13.36413841 339229 oxidoreductase like domain containing 1 OXNAD1 320.5883276 291.3158871 349.860768 1.200967003 0.264196513 0.394086401 1 0.663182762 0.783132924 92106 oxidoreductase NAD binding domain containing 1 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016491,GO:0055114" molecular_function|protein binding|cellular_component|biological_process|oxidoreductase activity|oxidation-reduction process OXR1 1574.30952 1550.216685 1598.402355 1.031083183 0.044160728 0.855346379 1 14.02240937 14.21633092 55074 oxidation resistance 1 "GO:0003674,GO:0005634,GO:0005730,GO:0005739,GO:0006979,GO:0007628,GO:0016491,GO:0043524,GO:0051402,GO:0055114,GO:0071447,GO:1900408,GO:1902083,GO:1903204" molecular_function|nucleus|nucleolus|mitochondrion|response to oxidative stress|adult walking behavior|oxidoreductase activity|negative regulation of neuron apoptotic process|neuron apoptotic process|oxidation-reduction process|cellular response to hydroperoxide|negative regulation of cellular response to oxidative stress|negative regulation of peptidyl-cysteine S-nitrosylation|negative regulation of oxidative stress-induced neuron death OXSM 201.6087786 183.1128433 220.1047139 1.2020168 0.26545706 0.468790814 1 2.49997337 2.954725216 54995 "3-oxoacyl-ACP synthase, mitochondrial" "GO:0004315,GO:0005739,GO:0005829,GO:0006633,GO:0006637,GO:0051790,GO:0051792" 3-oxoacyl-[acyl-carrier-protein] synthase activity|mitochondrion|cytosol|fatty acid biosynthetic process|acyl-CoA metabolic process|short-chain fatty acid biosynthetic process|medium-chain fatty acid biosynthetic process "hsa00061,hsa00780" Fatty acid biosynthesis|Biotin metabolism OXSR1 2763.617558 2947.49253 2579.742586 0.875232951 -0.19226104 0.416524016 1 31.06898263 26.73756607 9943 oxidative stress responsive kinase 1 "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005829,GO:0006468,GO:0006979,GO:0007165,GO:0007231,GO:0010820,GO:0018107,GO:0019901,GO:0035556,GO:0038116,GO:0038146,GO:0042802,GO:0046777,GO:0070062,GO:0071476,GO:0106310,GO:0106311,GO:1901017,GO:1990869" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|cytosol|protein phosphorylation|response to oxidative stress|signal transduction|osmosensory signaling pathway|positive regulation of T cell chemotaxis|peptidyl-threonine phosphorylation|protein kinase binding|intracellular signal transduction|chemokine (C-C motif) ligand 21 signaling pathway|chemokine (C-X-C motif) ligand 12 signaling pathway|identical protein binding|protein autophosphorylation|extracellular exosome|cellular hypotonic response|protein serine kinase activity|protein threonine kinase activity|negative regulation of potassium ion transmembrane transporter activity|cellular response to chemokine OXTR 51.67912472 57.22276355 46.13548589 0.806243583 -0.310712323 0.617964739 1 0.661871201 0.524699843 5021 oxytocin receptor "GO:0001967,GO:0001975,GO:0001992,GO:0004930,GO:0004990,GO:0005000,GO:0005886,GO:0005887,GO:0005902,GO:0005912,GO:0006936,GO:0007166,GO:0007186,GO:0007204,GO:0007507,GO:0007565,GO:0007595,GO:0007613,GO:0010701,GO:0016324,GO:0017046,GO:0021537,GO:0030431,GO:0032230,GO:0032355,GO:0032570,GO:0034059,GO:0034097,GO:0035176,GO:0042220,GO:0042277,GO:0042493,GO:0042711,GO:0042713,GO:0042755,GO:0043434,GO:0044849,GO:0045777,GO:0045907,GO:0048565,GO:0051965,GO:0051968,GO:0060137,GO:0060406,GO:0060455,GO:0070371,GO:0070474,GO:0120162" "suckling behavior|response to amphetamine|regulation of systemic arterial blood pressure by vasopressin|G protein-coupled receptor activity|oxytocin receptor activity|vasopressin receptor activity|plasma membrane|integral component of plasma membrane|microvillus|adherens junction|muscle contraction|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|heart development|female pregnancy|lactation|memory|positive regulation of norepinephrine secretion|apical plasma membrane|peptide hormone binding|telencephalon development|sleep|positive regulation of synaptic transmission, GABAergic|response to estradiol|response to progesterone|response to anoxia|response to cytokine|social behavior|response to cocaine|peptide binding|response to drug|maternal behavior|sperm ejaculation|eating behavior|response to peptide hormone|estrous cycle|positive regulation of blood pressure|positive regulation of vasoconstriction|digestive tract development|positive regulation of synapse assembly|positive regulation of synaptic transmission, glutamatergic|maternal process involved in parturition|positive regulation of penile erection|negative regulation of gastric acid secretion|ERK1 and ERK2 cascade|positive regulation of uterine smooth muscle contraction|positive regulation of cold-induced thermogenesis" "hsa04020,hsa04024,hsa04080,hsa04921" Calcium signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Oxytocin signaling pathway P2RX4 1328.307701 1614.722346 1041.893056 0.645245951 -0.632078911 0.008635572 0.573019799 49.299064 31.27772382 5025 purinergic receptor P2X 4 "GO:0001614,GO:0001894,GO:0002028,GO:0002931,GO:0004931,GO:0005102,GO:0005507,GO:0005515,GO:0005524,GO:0005639,GO:0005765,GO:0005886,GO:0005887,GO:0007165,GO:0007596,GO:0008217,GO:0008270,GO:0010524,GO:0010614,GO:0014069,GO:0016020,GO:0019228,GO:0019233,GO:0019722,GO:0030054,GO:0032308,GO:0033198,GO:0034220,GO:0034405,GO:0035590,GO:0042118,GO:0042802,GO:0043025,GO:0043195,GO:0043197,GO:0043536,GO:0044297,GO:0045296,GO:0045429,GO:0048266,GO:0048471,GO:0048678,GO:0050850,GO:0050920,GO:0050975,GO:0051897,GO:0051899,GO:0051928,GO:0055117,GO:0055119,GO:0060079,GO:0070062,GO:0070588,GO:0071294,GO:0071318,GO:0097190,GO:0099604,GO:1900027,GO:1904124,GO:1904141,GO:2001028" purinergic nucleotide receptor activity|tissue homeostasis|regulation of sodium ion transport|response to ischemia|extracellularly ATP-gated cation channel activity|signaling receptor binding|copper ion binding|protein binding|ATP binding|integral component of nuclear inner membrane|lysosomal membrane|plasma membrane|integral component of plasma membrane|signal transduction|blood coagulation|regulation of blood pressure|zinc ion binding|positive regulation of calcium ion transport into cytosol|negative regulation of cardiac muscle hypertrophy|postsynaptic density|membrane|neuronal action potential|sensory perception of pain|calcium-mediated signaling|cell junction|positive regulation of prostaglandin secretion|response to ATP|ion transmembrane transport|response to fluid shear stress|purinergic nucleotide receptor signaling pathway|endothelial cell activation|identical protein binding|neuronal cell body|terminal bouton|dendritic spine|positive regulation of blood vessel endothelial cell migration|cell body|cadherin binding|positive regulation of nitric oxide biosynthetic process|behavioral response to pain|perinuclear region of cytoplasm|response to axon injury|positive regulation of calcium-mediated signaling|regulation of chemotaxis|sensory perception of touch|positive regulation of protein kinase B signaling|membrane depolarization|positive regulation of calcium ion transport|regulation of cardiac muscle contraction|relaxation of cardiac muscle|excitatory postsynaptic potential|extracellular exosome|calcium ion transmembrane transport|cellular response to zinc ion|cellular response to ATP|apoptotic signaling pathway|ligand-gated calcium channel activity|regulation of ruffle assembly|microglial cell migration|positive regulation of microglial cell migration|positive regulation of endothelial cell chemotaxis "hsa04020,hsa04080" Calcium signaling pathway|Neuroactive ligand-receptor interaction P2RX5 552.3439567 597.1975686 507.4903448 0.849786354 -0.234827917 0.381133174 1 15.47152264 12.9274834 5026 purinergic receptor P2X 5 "GO:0001614,GO:0004888,GO:0004931,GO:0005216,GO:0005524,GO:0005639,GO:0005829,GO:0005886,GO:0005887,GO:0007165,GO:0007399,GO:0007596,GO:0010524,GO:0033198,GO:0035590,GO:0050850,GO:0060079,GO:0098655,GO:0098794" purinergic nucleotide receptor activity|transmembrane signaling receptor activity|extracellularly ATP-gated cation channel activity|ion channel activity|ATP binding|integral component of nuclear inner membrane|cytosol|plasma membrane|integral component of plasma membrane|signal transduction|nervous system development|blood coagulation|positive regulation of calcium ion transport into cytosol|response to ATP|purinergic nucleotide receptor signaling pathway|positive regulation of calcium-mediated signaling|excitatory postsynaptic potential|cation transmembrane transport|postsynapse "hsa04020,hsa04080" Calcium signaling pathway|Neuroactive ligand-receptor interaction P2RX7 10.16636505 14.56579436 5.766935736 0.395923188 -1.336707531 0.252942837 1 0.146036009 0.056851519 5027 purinergic receptor P2X 7 "GO:0001530,GO:0001614,GO:0002028,GO:0002931,GO:0004931,GO:0005102,GO:0005515,GO:0005524,GO:0005639,GO:0005737,GO:0005886,GO:0005887,GO:0007166,GO:0007596,GO:0010524,GO:0010628,GO:0016020,GO:0017121,GO:0019233,GO:0030501,GO:0032059,GO:0032060,GO:0032731,GO:0033198,GO:0034767,GO:0035585,GO:0035590,GO:0042802,GO:0043409,GO:0045779,GO:0045794,GO:0045821,GO:0046931,GO:0051495,GO:0051709,GO:0051899,GO:0060079,GO:0070588,GO:0071318,GO:0097190,GO:0097191,GO:0098794,GO:1904172,GO:1905114" lipopolysaccharide binding|purinergic nucleotide receptor activity|regulation of sodium ion transport|response to ischemia|extracellularly ATP-gated cation channel activity|signaling receptor binding|protein binding|ATP binding|integral component of nuclear inner membrane|cytoplasm|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|blood coagulation|positive regulation of calcium ion transport into cytosol|positive regulation of gene expression|membrane|plasma membrane phospholipid scrambling|sensory perception of pain|positive regulation of bone mineralization|bleb|bleb assembly|positive regulation of interleukin-1 beta production|response to ATP|positive regulation of ion transmembrane transport|calcium-mediated signaling using extracellular calcium source|purinergic nucleotide receptor signaling pathway|identical protein binding|negative regulation of MAPK cascade|negative regulation of bone resorption|negative regulation of cell volume|positive regulation of glycolytic process|pore complex assembly|positive regulation of cytoskeleton organization|regulation of killing of cells of other organism|membrane depolarization|excitatory postsynaptic potential|calcium ion transmembrane transport|cellular response to ATP|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|postsynapse|positive regulation of bleb assembly|cell surface receptor signaling pathway involved in cell-cell signaling "hsa04020,hsa04080,hsa04621" Calcium signaling pathway|Neuroactive ligand-receptor interaction|NOD-like receptor signaling pathway P2RY1 36.26603088 43.69738307 28.83467868 0.65987198 -0.599741937 0.383206037 1 0.369638457 0.239832489 5028 purinergic receptor P2Y1 "GO:0001621,GO:0001934,GO:0001973,GO:0005515,GO:0005524,GO:0005739,GO:0005886,GO:0005887,GO:0005929,GO:0007166,GO:0007186,GO:0007193,GO:0007200,GO:0007204,GO:0007568,GO:0008347,GO:0008360,GO:0009612,GO:0009986,GO:0010469,GO:0010700,GO:0014069,GO:0016323,GO:0016324,GO:0019233,GO:0023019,GO:0030168,GO:0030425,GO:0031686,GO:0032962,GO:0035589,GO:0038023,GO:0042755,GO:0043270,GO:0043531,GO:0044297,GO:0045028,GO:0045031,GO:0045211,GO:0045944,GO:0046887,GO:0046982,GO:0051100,GO:0060406,GO:0070374,GO:0070848,GO:0071318,GO:0071415,GO:0072659,GO:0090075,GO:0097110,GO:0097746,GO:0098978,GO:0099059,GO:0099509,GO:2000300" G protein-coupled ADP receptor activity|positive regulation of protein phosphorylation|G protein-coupled adenosine receptor signaling pathway|protein binding|ATP binding|mitochondrion|plasma membrane|integral component of plasma membrane|cilium|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|aging|glial cell migration|regulation of cell shape|response to mechanical stimulus|cell surface|regulation of signaling receptor activity|negative regulation of norepinephrine secretion|postsynaptic density|basolateral plasma membrane|apical plasma membrane|sensory perception of pain|signal transduction involved in regulation of gene expression|platelet activation|dendrite|A1 adenosine receptor binding|positive regulation of inositol trisphosphate biosynthetic process|G protein-coupled purinergic nucleotide receptor signaling pathway|signaling receptor activity|eating behavior|positive regulation of ion transport|ADP binding|cell body|G protein-coupled purinergic nucleotide receptor activity|G protein-coupled ATP receptor activity|postsynaptic membrane|positive regulation of transcription by RNA polymerase II|positive regulation of hormone secretion|protein heterodimerization activity|negative regulation of binding|positive regulation of penile erection|positive regulation of ERK1 and ERK2 cascade|response to growth factor|cellular response to ATP|cellular response to purine-containing compound|protein localization to plasma membrane|relaxation of muscle|scaffold protein binding|blood vessel diameter maintenance|glutamatergic synapse|integral component of presynaptic active zone membrane|regulation of presynaptic cytosolic calcium ion concentration|regulation of synaptic vesicle exocytosis "hsa04015,hsa04080,hsa04611,hsa04742" Rap1 signaling pathway|Neuroactive ligand-receptor interaction|Platelet activation|Taste transduction P2RY10 5.365615685 2.080827765 8.650403604 4.157193473 2.055609892 0.230262796 1 0.030881522 0.126232189 27334 P2Y receptor family member 10 "GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0035025,GO:0035589,GO:0045028,GO:0051482" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|positive regulation of Rho protein signal transduction|G protein-coupled purinergic nucleotide receptor signaling pathway|G protein-coupled purinergic nucleotide receptor activity|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway hsa04080 Neuroactive ligand-receptor interaction P2RY2 595.8721487 806.320759 385.4235384 0.478002748 -1.064909184 6.00E-05 0.024867406 3.576748147 1.681086004 5029 purinergic receptor P2Y2 "GO:0005515,GO:0005886,GO:0005887,GO:0006873,GO:0007186,GO:0007200,GO:0035589,GO:0038023,GO:0045028,GO:0070257,GO:0071318,GO:0097746" protein binding|plasma membrane|integral component of plasma membrane|cellular ion homeostasis|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|G protein-coupled purinergic nucleotide receptor signaling pathway|signaling receptor activity|G protein-coupled purinergic nucleotide receptor activity|positive regulation of mucus secretion|cellular response to ATP|blood vessel diameter maintenance "hsa04080,hsa04750" Neuroactive ligand-receptor interaction|Inflammatory mediator regulation of TRP channels P2RY4 5.603389465 8.323311061 2.883467868 0.346432789 -1.529352609 0.352439314 1 0.217851797 0.074208101 5030 pyrimidinergic receptor P2Y4 "GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0007186,GO:0007200,GO:0007204,GO:0016323,GO:0016324,GO:0030321,GO:0035589,GO:0045028,GO:0045030,GO:0071318,GO:0071380,GO:0098978,GO:0099059,GO:0099509,GO:2000300" protein binding|ATP binding|plasma membrane|integral component of plasma membrane|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|basolateral plasma membrane|apical plasma membrane|transepithelial chloride transport|G protein-coupled purinergic nucleotide receptor signaling pathway|G protein-coupled purinergic nucleotide receptor activity|G protein-coupled UTP receptor activity|cellular response to ATP|cellular response to prostaglandin E stimulus|glutamatergic synapse|integral component of presynaptic active zone membrane|regulation of presynaptic cytosolic calcium ion concentration|regulation of synaptic vesicle exocytosis "hsa04080,hsa04742" Neuroactive ligand-receptor interaction|Taste transduction P2RY6 378.078433 438.0142446 318.1426214 0.726329395 -0.461304126 0.116073724 1 3.789885732 2.706642615 5031 pyrimidinergic receptor P2Y6 "GO:0001621,GO:0004930,GO:0005515,GO:0005886,GO:0005887,GO:0006909,GO:0007186,GO:0007200,GO:0007202,GO:0031587,GO:0032962,GO:0035589,GO:0045029,GO:0045030,GO:0070374,GO:0071415,GO:1904707,GO:1905835" "G protein-coupled ADP receptor activity|G protein-coupled receptor activity|protein binding|plasma membrane|integral component of plasma membrane|phagocytosis|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|activation of phospholipase C activity|positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|positive regulation of inositol trisphosphate biosynthetic process|G protein-coupled purinergic nucleotide receptor signaling pathway|G protein-coupled UDP receptor activity|G protein-coupled UTP receptor activity|positive regulation of ERK1 and ERK2 cascade|cellular response to purine-containing compound|positive regulation of vascular associated smooth muscle cell proliferation|cellular response to pyrimidine ribonucleotide" hsa04080 Neuroactive ligand-receptor interaction P3H1 1342.726269 1412.882053 1272.570486 0.900691238 -0.150895467 0.530924023 1 29.66283178 26.269979 64175 prolyl 3-hydroxylase 1 "GO:0003674,GO:0005506,GO:0005515,GO:0005518,GO:0005783,GO:0005788,GO:0006457,GO:0008285,GO:0010976,GO:0016020,GO:0018126,GO:0019511,GO:0019797,GO:0031418,GO:0032963,GO:0032991,GO:0050708,GO:0050821,GO:0055114,GO:0060348,GO:0061077,GO:0062023,GO:0070062,GO:1901874" molecular_function|iron ion binding|protein binding|collagen binding|endoplasmic reticulum|endoplasmic reticulum lumen|protein folding|negative regulation of cell population proliferation|positive regulation of neuron projection development|membrane|protein hydroxylation|peptidyl-proline hydroxylation|procollagen-proline 3-dioxygenase activity|L-ascorbic acid binding|collagen metabolic process|protein-containing complex|regulation of protein secretion|protein stabilization|oxidation-reduction process|bone development|chaperone-mediated protein folding|collagen-containing extracellular matrix|extracellular exosome|negative regulation of post-translational protein modification P3H2 935.3917158 1026.888502 843.8949294 0.821798012 -0.283144255 0.252537553 1 14.83170555 11.98470531 55214 prolyl 3-hydroxylase 2 "GO:0005506,GO:0005604,GO:0005654,GO:0005783,GO:0005788,GO:0005794,GO:0005829,GO:0008285,GO:0016529,GO:0019511,GO:0019797,GO:0031418,GO:0032963,GO:0043231,GO:0055114" iron ion binding|basement membrane|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|Golgi apparatus|cytosol|negative regulation of cell population proliferation|sarcoplasmic reticulum|peptidyl-proline hydroxylation|procollagen-proline 3-dioxygenase activity|L-ascorbic acid binding|collagen metabolic process|intracellular membrane-bounded organelle|oxidation-reduction process P3H3 939.5143567 933.2512527 945.7774607 1.013422117 0.019235221 0.942617841 1 18.93040825 18.86346788 10536 prolyl 3-hydroxylase 3 "GO:0005506,GO:0005783,GO:0008285,GO:0017185,GO:0019511,GO:0019797,GO:0031418,GO:0032963,GO:0032964,GO:0055114,GO:1902494" iron ion binding|endoplasmic reticulum|negative regulation of cell population proliferation|peptidyl-lysine hydroxylation|peptidyl-proline hydroxylation|procollagen-proline 3-dioxygenase activity|L-ascorbic acid binding|collagen metabolic process|collagen biosynthetic process|oxidation-reduction process|catalytic complex P3H4 634.046629 685.6327487 582.4605093 0.849522591 -0.235275781 0.367230743 1 11.75046874 9.815248571 10609 prolyl 3-hydroxylase family member 4 (inactive) "GO:0000794,GO:0000795,GO:0005518,GO:0005730,GO:0005783,GO:0007130,GO:0017185,GO:0030199,GO:0032964,GO:0043231,GO:0046849,GO:1902494" condensed nuclear chromosome|synaptonemal complex|collagen binding|nucleolus|endoplasmic reticulum|synaptonemal complex assembly|peptidyl-lysine hydroxylation|collagen fibril organization|collagen biosynthetic process|intracellular membrane-bounded organelle|bone remodeling|catalytic complex P4HA1 2599.922791 2296.193439 2903.652143 1.264550318 0.338624445 0.1521696 1 42.15466929 52.414685 5033 prolyl 4-hydroxylase subunit alpha 1 "GO:0004656,GO:0005506,GO:0005515,GO:0005739,GO:0005783,GO:0005788,GO:0016020,GO:0016702,GO:0018401,GO:0031418,GO:0042802,GO:0043231,GO:0055114" "procollagen-proline 4-dioxygenase activity|iron ion binding|protein binding|mitochondrion|endoplasmic reticulum|endoplasmic reticulum lumen|membrane|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|L-ascorbic acid binding|identical protein binding|intracellular membrane-bounded organelle|oxidation-reduction process" hsa00330 Arginine and proline metabolism P4HA2 2184.743661 2196.313706 2173.173617 0.989464124 -0.015280697 0.950534662 1 22.0118734 21.4155009 8974 prolyl 4-hydroxylase subunit alpha 2 "GO:0004656,GO:0005506,GO:0005654,GO:0005783,GO:0005788,GO:0005829,GO:0009055,GO:0016702,GO:0018401,GO:0022900,GO:0031418,GO:0043231" "procollagen-proline 4-dioxygenase activity|iron ion binding|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|cytosol|electron transfer activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|electron transport chain|L-ascorbic acid binding|intracellular membrane-bounded organelle" hsa00330 Arginine and proline metabolism P4HA3 21.45743232 20.80827765 22.10658699 1.062393888 0.087318751 0.979502542 1 0.492460991 0.514432711 283208 prolyl 4-hydroxylase subunit alpha 3 "GO:0004656,GO:0005506,GO:0005515,GO:0005783,GO:0005788,GO:0016702,GO:0018401,GO:0031418,GO:0055114" "procollagen-proline 4-dioxygenase activity|iron ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|L-ascorbic acid binding|oxidation-reduction process" hsa00330 Arginine and proline metabolism P4HB 15239.9281 15010.05108 15469.80511 1.030629744 0.043526135 0.868785499 1 327.7654824 332.1521486 5034 prolyl 4-hydroxylase subunit beta "GO:0003723,GO:0003756,GO:0003779,GO:0004656,GO:0005178,GO:0005515,GO:0005576,GO:0005783,GO:0005788,GO:0005793,GO:0005829,GO:0005856,GO:0005925,GO:0006457,GO:0009897,GO:0015037,GO:0016222,GO:0016972,GO:0018215,GO:0018401,GO:0030027,GO:0032991,GO:0034378,GO:0034379,GO:0034975,GO:0034976,GO:0035722,GO:0038155,GO:0042470,GO:0043687,GO:0044267,GO:0045785,GO:0046598,GO:0046982,GO:0055114,GO:0070062,GO:0071456,GO:1900026,GO:1902175" RNA binding|protein disulfide isomerase activity|actin binding|procollagen-proline 4-dioxygenase activity|integrin binding|protein binding|extracellular region|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|cytosol|cytoskeleton|focal adhesion|protein folding|external side of plasma membrane|peptide disulfide oxidoreductase activity|procollagen-proline 4-dioxygenase complex|thiol oxidase activity|protein phosphopantetheinylation|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|lamellipodium|protein-containing complex|chylomicron assembly|very-low-density lipoprotein particle assembly|protein folding in endoplasmic reticulum|response to endoplasmic reticulum stress|interleukin-12-mediated signaling pathway|interleukin-23-mediated signaling pathway|melanosome|post-translational protein modification|cellular protein metabolic process|positive regulation of cell adhesion|positive regulation of viral entry into host cell|protein heterodimerization activity|oxidation-reduction process|extracellular exosome|cellular response to hypoxia|positive regulation of substrate adhesion-dependent cell spreading|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway hsa04141 Protein processing in endoplasmic reticulum P4HTM 318.9283271 336.0536841 301.8029702 0.898079636 -0.155084716 0.621344465 1 8.291524494 7.321843052 54681 "prolyl 4-hydroxylase, transmembrane" "GO:0004656,GO:0005506,GO:0005509,GO:0005783,GO:0005789,GO:0016021,GO:0016706,GO:0018401,GO:0031418,GO:0045646,GO:0055114" procollagen-proline 4-dioxygenase activity|iron ion binding|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|2-oxoglutarate-dependent dioxygenase activity|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|L-ascorbic acid binding|regulation of erythrocyte differentiation|oxidation-reduction process PA2G4 5200.11231 4725.559855 5674.664764 1.200844966 0.264049905 0.272239497 1 105.6975877 124.8024744 5036 proliferation-associated 2G4 "GO:0003676,GO:0003714,GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005730,GO:0005737,GO:0006364,GO:0006417,GO:0016020,GO:0031625,GO:0035578,GO:0043066,GO:0043312,GO:0045597,GO:0045892,GO:0070062" "nucleic acid binding|transcription corepressor activity|RNA binding|protein binding|extracellular region|nucleus|nucleolus|cytoplasm|rRNA processing|regulation of translation|membrane|ubiquitin protein ligase binding|azurophil granule lumen|negative regulation of apoptotic process|neutrophil degranulation|positive regulation of cell differentiation|negative regulation of transcription, DNA-templated|extracellular exosome" PAAF1 639.159994 618.0058463 660.3141418 1.068459377 0.095532058 0.717698283 1 5.573138927 5.855029167 80227 proteasomal ATPase associated factor 1 "GO:0000502,GO:0005515,GO:0016032" proteasome complex|protein binding|viral process PABIR1 372.3762783 376.6298255 368.1227311 0.977412584 -0.032960415 0.920531189 1 3.653224568 3.510956709 116224 PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 "GO:0004865,GO:0005515,GO:0005634,GO:0005737,GO:0030307,GO:0032436,GO:0032515,GO:0044818" protein serine/threonine phosphatase inhibitor activity|protein binding|nucleus|cytoplasm|positive regulation of cell growth|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of phosphoprotein phosphatase activity|mitotic G2/M transition checkpoint PABIR2 2650.88798 2435.608899 2866.167061 1.176776395 0.234840213 0.32076864 1 47.50876115 54.9716576 159090 PABIR family member 2 PABIR3 241.9867752 259.0630568 224.9104937 0.868168918 -0.203952322 0.552906672 1 2.219216565 1.894414885 159091 PABIR family member 3 PABPC1 40244.90196 43285.37917 37204.42474 0.859514817 -0.218405585 0.482632185 1 802.9409563 678.5910965 26986 poly(A) binding protein cytoplasmic 1 "GO:0000184,GO:0000398,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005925,GO:0006378,GO:0006413,GO:0008022,GO:0008143,GO:0008266,GO:0008494,GO:0010494,GO:0016020,GO:0030027,GO:0031047,GO:0031252,GO:0036464,GO:0043488,GO:0045070,GO:0045727,GO:0048255,GO:0060213,GO:0070062,GO:0071013,GO:1900153,GO:1990904,GO:2000623" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|cytosol|focal adhesion|mRNA polyadenylation|translational initiation|protein C-terminus binding|poly(A) binding|poly(U) RNA binding|translation activator activity|cytoplasmic stress granule|membrane|lamellipodium|gene silencing by RNA|cell leading edge|cytoplasmic ribonucleoprotein granule|regulation of mRNA stability|positive regulation of viral genome replication|positive regulation of translation|mRNA stabilization|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|extracellular exosome|catalytic step 2 spliceosome|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|ribonucleoprotein complex|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" "hsa03013,hsa03015,hsa03018" RNA transport|mRNA surveillance pathway|RNA degradation PABPC1L 1148.305424 1380.629222 915.9816261 0.663452295 -0.591935361 0.014933834 0.712638468 34.41459323 22.45037088 80336 poly(A) binding protein cytoplasmic 1 like "GO:0001556,GO:0003723,GO:0003730,GO:0005634,GO:0005829,GO:0006338,GO:0006378,GO:0008143,GO:0008266,GO:0010494,GO:0048096,GO:0051647,GO:0070062,GO:1990904" oocyte maturation|RNA binding|mRNA 3'-UTR binding|nucleus|cytosol|chromatin remodeling|mRNA polyadenylation|poly(A) binding|poly(U) RNA binding|cytoplasmic stress granule|chromatin-mediated maintenance of transcription|nucleus localization|extracellular exosome|ribonucleoprotein complex "hsa03013,hsa03015,hsa03018" RNA transport|mRNA surveillance pathway|RNA degradation PABPC3 22.4978462 22.88910542 22.10658699 0.965812625 -0.050184772 1 1 0.3916478 0.371928748 5042 poly(A) binding protein cytoplasmic 3 "GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0008143,GO:0008266,GO:0010494,GO:0016071,GO:0070062,GO:1990904" RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|cytosol|poly(A) binding|poly(U) RNA binding|cytoplasmic stress granule|mRNA metabolic process|extracellular exosome|ribonucleoprotein complex "hsa03013,hsa03015,hsa03018" RNA transport|mRNA surveillance pathway|RNA degradation PABPC4 3533.364585 3789.187361 3277.54181 0.864972222 -0.209274293 0.378134725 1 64.36090554 54.73882678 8761 poly(A) binding protein cytoplasmic 4 "GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006396,GO:0006401,GO:0006412,GO:0007596,GO:0008143,GO:0008266,GO:0010494,GO:0017130,GO:0043488,GO:0061515,GO:1990904" RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|cytosol|RNA processing|RNA catabolic process|translation|blood coagulation|poly(A) binding|poly(U) RNA binding|cytoplasmic stress granule|poly(C) RNA binding|regulation of mRNA stability|myeloid cell development|ribonucleoprotein complex "hsa03013,hsa03015,hsa03018" RNA transport|mRNA surveillance pathway|RNA degradation PABPC4L 176.1431762 170.6278768 181.6584757 1.064647109 0.09037531 0.826327373 1 1.806765115 1.891378964 132430 poly(A) binding protein cytoplasmic 4 like "GO:0003723,GO:0003730,GO:0005634,GO:0005829,GO:0008143,GO:0008266,GO:0010494,GO:1990904" RNA binding|mRNA 3'-UTR binding|nucleus|cytosol|poly(A) binding|poly(U) RNA binding|cytoplasmic stress granule|ribonucleoprotein complex "hsa03013,hsa03015,hsa03018" RNA transport|mRNA surveillance pathway|RNA degradation PABPN1 59.84391992 69.70773014 49.98010971 0.716995226 -0.479964582 0.39961292 1 1.873199114 1.320600283 8106 poly(A) binding protein nuclear 1 "GO:0000165,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006369,GO:0006396,GO:0006936,GO:0016607,GO:0016973,GO:0031124,GO:0042405,GO:0046778,GO:0070063,GO:0071222,GO:1904247,GO:1990904" "MAPK cascade|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|termination of RNA polymerase II transcription|RNA processing|muscle contraction|nuclear speck|poly(A)+ mRNA export from nucleus|mRNA 3'-end processing|nuclear inclusion body|modification by virus of host mRNA processing|RNA polymerase binding|cellular response to lipopolysaccharide|positive regulation of polynucleotide adenylyltransferase activity|ribonucleoprotein complex" "hsa03015,hsa05164" mRNA surveillance pathway|Influenza A PACC1 509.0529241 495.2370081 522.8688401 1.055795168 0.078329968 0.779550113 1 8.589499161 8.916998429 55248 proton activated chloride channel 1 "GO:0005515,GO:0005887,GO:0006821,GO:0009986,GO:0034707,GO:0061797,GO:1902476" protein binding|integral component of plasma membrane|chloride transport|cell surface|chloride channel complex|pH-gated chloride channel activity|chloride transmembrane transport PACRGL 204.6753001 225.7698125 183.5807876 0.813132569 -0.298437514 0.410922092 1 5.442149931 4.351139802 133015 parkin coregulated like GO:0005515 protein binding PACS1 2260.580633 2231.687778 2289.473487 1.025893277 0.036880656 0.877792029 1 19.91989882 20.09372667 55690 phosphofurin acidic cluster sorting protein 1 "GO:0005515,GO:0005794,GO:0005829,GO:0030137,GO:0034067,GO:0044325,GO:0050690,GO:0072659" protein binding|Golgi apparatus|cytosol|COPI-coated vesicle|protein localization to Golgi apparatus|ion channel binding|regulation of defense response to virus by virus|protein localization to plasma membrane PACS2 877.9110568 956.1403581 799.6817554 0.836364398 -0.257796443 0.300876537 1 7.743164431 6.36773818 23241 phosphofurin acidic cluster sorting protein 2 "GO:0000045,GO:0005515,GO:0005739,GO:0005783,GO:0006915,GO:0016032,GO:0032469,GO:0034497,GO:0044325,GO:0072659,GO:1990456" autophagosome assembly|protein binding|mitochondrion|endoplasmic reticulum|apoptotic process|viral process|endoplasmic reticulum calcium ion homeostasis|protein localization to phagophore assembly site|ion channel binding|protein localization to plasma membrane|mitochondrion-endoplasmic reticulum membrane tethering PACSIN2 2284.9857 2292.031783 2277.939616 0.99385167 -0.008897546 0.972017894 1 31.81314011 31.08846567 11252 protein kinase C and casein kinase substrate in neurons 2 "GO:0005215,GO:0005515,GO:0005543,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005856,GO:0005886,GO:0005901,GO:0005911,GO:0005925,GO:0007010,GO:0016607,GO:0019898,GO:0030036,GO:0030100,GO:0030659,GO:0032587,GO:0036010,GO:0042802,GO:0043231,GO:0045296,GO:0045806,GO:0048858,GO:0050804,GO:0055038,GO:0061024,GO:0070062,GO:0070300,GO:0070836,GO:0072584,GO:0097320,GO:0098978" transporter activity|protein binding|phospholipid binding|cytoplasm|endosome|early endosome|cytosol|cytoskeleton|plasma membrane|caveola|cell-cell junction|focal adhesion|cytoskeleton organization|nuclear speck|extrinsic component of membrane|actin cytoskeleton organization|regulation of endocytosis|cytoplasmic vesicle membrane|ruffle membrane|protein localization to endosome|identical protein binding|intracellular membrane-bounded organelle|cadherin binding|negative regulation of endocytosis|cell projection morphogenesis|modulation of chemical synaptic transmission|recycling endosome membrane|membrane organization|extracellular exosome|phosphatidic acid binding|caveola assembly|caveolin-mediated endocytosis|plasma membrane tubulation|glutamatergic synapse PACSIN3 950.0229056 893.7155252 1006.330286 1.12600739 0.171216296 0.489727097 1 22.9417773 25.40033702 29763 protein kinase C and casein kinase substrate in neurons 3 "GO:0005515,GO:0005543,GO:0005737,GO:0005768,GO:0005829,GO:0005856,GO:0005886,GO:0006897,GO:0007010,GO:0008092,GO:0008289,GO:0019855,GO:0030100,GO:0042802,GO:0045806,GO:0051044,GO:0051926,GO:0070062,GO:0097320" protein binding|phospholipid binding|cytoplasm|endosome|cytosol|cytoskeleton|plasma membrane|endocytosis|cytoskeleton organization|cytoskeletal protein binding|lipid binding|calcium channel inhibitor activity|regulation of endocytosis|identical protein binding|negative regulation of endocytosis|positive regulation of membrane protein ectodomain proteolysis|negative regulation of calcium ion transport|extracellular exosome|plasma membrane tubulation PADI1 12.08867696 14.56579436 9.61155956 0.65987198 -0.599741937 0.61074606 1 0.188998219 0.122627698 29943 peptidyl arginine deiminase 1 "GO:0004668,GO:0005509,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006325,GO:0018101,GO:0036414" protein-arginine deiminase activity|calcium ion binding|nucleus|nucleoplasm|cytoplasm|cytosol|chromatin organization|protein citrullination|histone citrullination PADI2 23.81566283 32.25283036 15.3784953 0.476810721 -1.06851142 0.181092078 1 0.375087008 0.175852769 11240 peptidyl arginine deiminase 2 "GO:0004668,GO:0005509,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0006325,GO:0010848,GO:0018101,GO:0021762,GO:0030331,GO:0030520,GO:0035327,GO:0035578,GO:0036413,GO:0036414,GO:0042803,GO:0043312,GO:0048096,GO:0070062,GO:0070100,GO:1901624,GO:1990830" protein-arginine deiminase activity|calcium ion binding|extracellular region|nucleus|cytoplasm|cytosol|chromatin organization|regulation of chromatin disassembly|protein citrullination|substantia nigra development|estrogen receptor binding|intracellular estrogen receptor signaling pathway|transcriptionally active chromatin|azurophil granule lumen|histone H3-R26 citrullination|histone citrullination|protein homodimerization activity|neutrophil degranulation|chromatin-mediated maintenance of transcription|extracellular exosome|negative regulation of chemokine-mediated signaling pathway|negative regulation of lymphocyte chemotaxis|cellular response to leukemia inhibitory factor PADI3 26.09463541 41.61655531 10.57271552 0.254050712 -1.976811586 0.012416039 0.66065886 0.431429501 0.107770881 51702 peptidyl arginine deiminase 3 "GO:0004668,GO:0005509,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006325,GO:0018101,GO:0036414,GO:0042802" protein-arginine deiminase activity|calcium ion binding|protein binding|nucleus|cytoplasm|cytosol|chromatin organization|protein citrullination|histone citrullination|identical protein binding PAEP 9.646158105 13.52538047 5.766935736 0.426378818 -1.229792327 0.308194169 1 0.679684272 0.284953516 5047 progestagen associated endometrial protein "GO:0005515,GO:0005549,GO:0005576,GO:0005615,GO:0006915,GO:0007275,GO:0032725,GO:0036094,GO:1902491,GO:2000359" protein binding|odorant binding|extracellular region|extracellular space|apoptotic process|multicellular organism development|positive regulation of granulocyte macrophage colony-stimulating factor production|small molecule binding|negative regulation of sperm capacitation|regulation of binding of sperm to zona pellucida PAF1 949.3341219 913.483389 985.1848549 1.078492359 0.109015955 0.661656952 1 22.15951344 23.49895076 54623 "PAF1 homolog, Paf1/RNA polymerase II complex component" "GO:0000122,GO:0000993,GO:0001711,GO:0003682,GO:0005515,GO:0005654,GO:0005737,GO:0006366,GO:0006368,GO:0006378,GO:0010390,GO:0016020,GO:0016055,GO:0016567,GO:0016584,GO:0016593,GO:0019827,GO:0030054,GO:0031062,GO:0031442,GO:0033523,GO:0034504,GO:0035327,GO:0045638,GO:0071222,GO:1902808" negative regulation of transcription by RNA polymerase II|RNA polymerase II complex binding|endodermal cell fate commitment|chromatin binding|protein binding|nucleoplasm|cytoplasm|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|mRNA polyadenylation|histone monoubiquitination|membrane|Wnt signaling pathway|protein ubiquitination|nucleosome positioning|Cdc73/Paf1 complex|stem cell population maintenance|cell junction|positive regulation of histone methylation|positive regulation of mRNA 3'-end processing|histone H2B ubiquitination|protein localization to nucleus|transcriptionally active chromatin|negative regulation of myeloid cell differentiation|cellular response to lipopolysaccharide|positive regulation of cell cycle G1/S phase transition PAFAH1B1 3075.74418 3168.060273 2983.428087 0.941720747 -0.086628781 0.715344108 1 28.03408292 25.95850463 5048 platelet activating factor acetylhydrolase 1b regulatory subunit 1 "GO:0000086,GO:0000132,GO:0000226,GO:0000235,GO:0000776,GO:0001675,GO:0001764,GO:0005515,GO:0005635,GO:0005813,GO:0005829,GO:0005875,GO:0005881,GO:0005938,GO:0007017,GO:0007097,GO:0007268,GO:0007281,GO:0007405,GO:0007611,GO:0008017,GO:0008090,GO:0008201,GO:0008247,GO:0008344,GO:0010389,GO:0016042,GO:0019226,GO:0021540,GO:0021766,GO:0021819,GO:0021987,GO:0030036,GO:0031023,GO:0031252,GO:0031514,GO:0031965,GO:0034452,GO:0038026,GO:0042802,GO:0043005,GO:0043025,GO:0043274,GO:0045202,GO:0046469,GO:0046982,GO:0047496,GO:0048471,GO:0048854,GO:0050885,GO:0051010,GO:0051012,GO:0051219,GO:0051301,GO:0070062,GO:0070840,GO:0097711,GO:1904115,GO:2000574" G2/M transition of mitotic cell cycle|establishment of mitotic spindle orientation|microtubule cytoskeleton organization|astral microtubule|kinetochore|acrosome assembly|neuron migration|protein binding|nuclear envelope|centrosome|cytosol|microtubule associated complex|cytoplasmic microtubule|cell cortex|microtubule-based process|nuclear migration|chemical synaptic transmission|germ cell development|neuroblast proliferation|learning or memory|microtubule binding|retrograde axonal transport|heparin binding|1-alkyl-2-acetylglycerophosphocholine esterase complex|adult locomotory behavior|regulation of G2/M transition of mitotic cell cycle|lipid catabolic process|transmission of nerve impulse|corpus callosum morphogenesis|hippocampus development|layer formation in cerebral cortex|cerebral cortex development|actin cytoskeleton organization|microtubule organizing center organization|cell leading edge|motile cilium|nuclear membrane|dynactin binding|reelin-mediated signaling pathway|identical protein binding|neuron projection|neuronal cell body|phospholipase binding|synapse|platelet activating factor metabolic process|protein heterodimerization activity|vesicle transport along microtubule|perinuclear region of cytoplasm|brain morphogenesis|neuromuscular process controlling balance|microtubule plus-end binding|microtubule sliding|phosphoprotein binding|cell division|extracellular exosome|dynein complex binding|ciliary basal body-plasma membrane docking|axon cytoplasm|regulation of microtubule motor activity hsa00565 Ether lipid metabolism PAFAH1B2 3348.138159 3102.514198 3593.762119 1.158338654 0.212057104 0.371350281 1 24.49703811 27.90103445 5049 platelet activating factor acetylhydrolase 1b catalytic subunit 2 "GO:0001650,GO:0003847,GO:0005515,GO:0005576,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006629,GO:0007283,GO:0007420,GO:0008247,GO:0016042,GO:0016239,GO:0034774,GO:0042803,GO:0043312,GO:0044877,GO:0046982,GO:0047179,GO:0070062,GO:1904813" fibrillar center|1-alkyl-2-acetylglycerophosphocholine esterase activity|protein binding|extracellular region|nucleolus|cytoplasm|cytosol|plasma membrane|lipid metabolic process|spermatogenesis|brain development|1-alkyl-2-acetylglycerophosphocholine esterase complex|lipid catabolic process|positive regulation of macroautophagy|secretory granule lumen|protein homodimerization activity|neutrophil degranulation|protein-containing complex binding|protein heterodimerization activity|platelet-activating factor acetyltransferase activity|extracellular exosome|ficolin-1-rich granule lumen hsa00565 Ether lipid metabolism PAFAH1B3 543.3224156 524.3685969 562.2762343 1.072291967 0.100697781 0.712425523 1 24.16631111 25.47971661 5050 platelet activating factor acetylhydrolase 1b catalytic subunit 3 "GO:0003847,GO:0005515,GO:0005737,GO:0005829,GO:0006629,GO:0007283,GO:0007399,GO:0007420,GO:0008247,GO:0016020,GO:0016042,GO:0042802,GO:0042803,GO:0044877,GO:0046982,GO:0047179" 1-alkyl-2-acetylglycerophosphocholine esterase activity|protein binding|cytoplasm|cytosol|lipid metabolic process|spermatogenesis|nervous system development|brain development|1-alkyl-2-acetylglycerophosphocholine esterase complex|membrane|lipid catabolic process|identical protein binding|protein homodimerization activity|protein-containing complex binding|protein heterodimerization activity|platelet-activating factor acetyltransferase activity hsa00565 Ether lipid metabolism PAFAH2 209.2728742 245.5376763 173.0080721 0.704609063 -0.505105063 0.157340342 1 2.926936454 2.027835386 5051 platelet activating factor acetylhydrolase 2 "GO:0003847,GO:0005543,GO:0005737,GO:0005789,GO:0006629,GO:0007596,GO:0016042,GO:0043066,GO:0047179" 1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding|cytoplasm|endoplasmic reticulum membrane|lipid metabolic process|blood coagulation|lipid catabolic process|negative regulation of apoptotic process|platelet-activating factor acetyltransferase activity hsa00565 Ether lipid metabolism PAG1 561.7630162 478.590386 644.9356465 1.347573343 0.430363795 0.106251368 1 2.338964221 3.099182624 55824 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 "GO:0002250,GO:0005515,GO:0005886,GO:0007165,GO:0016021,GO:0035556,GO:0035591,GO:0042169,GO:0045121,GO:0050852,GO:0050863,GO:0050868" adaptive immune response|protein binding|plasma membrane|signal transduction|integral component of membrane|intracellular signal transduction|signaling adaptor activity|SH2 domain binding|membrane raft|T cell receptor signaling pathway|regulation of T cell activation|negative regulation of T cell activation PAGE5 7.406814487 5.202069413 9.61155956 1.847641543 0.88568489 0.555147706 1 0.502034148 0.912057366 90737 PAGE family member 5 GO:0005515 protein binding PAGR1 660.8998595 633.6120545 688.1876645 1.086134109 0.119202249 0.648386433 1 8.728629536 9.321819569 79447 PAXIP1 associated glutamate rich protein 1 "GO:0005515,GO:0005634,GO:0006281,GO:0006310,GO:0030331,GO:0033148,GO:0035097,GO:0044666,GO:0045944,GO:0051568,GO:1902808" protein binding|nucleus|DNA repair|DNA recombination|estrogen receptor binding|positive regulation of intracellular estrogen receptor signaling pathway|histone methyltransferase complex|MLL3/4 complex|positive regulation of transcription by RNA polymerase II|histone H3-K4 methylation|positive regulation of cell cycle G1/S phase transition PAICS 5372.02279 5163.5741 5580.47148 1.080738142 0.112017007 0.642144267 1 61.84256271 65.71721282 10606 phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase "GO:0004638,GO:0004639,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006189,GO:0009113,GO:0009168,GO:0016020,GO:0042802,GO:0043727,GO:0045296,GO:0070062" phosphoribosylaminoimidazole carboxylase activity|phosphoribosylaminoimidazolesuccinocarboxamide synthase activity|protein binding|ATP binding|cytoplasm|cytosol|'de novo' IMP biosynthetic process|purine nucleobase biosynthetic process|purine ribonucleoside monophosphate biosynthetic process|membrane|identical protein binding|5-amino-4-imidazole carboxylate lyase activity|cadherin binding|extracellular exosome hsa00230 Purine metabolism PAIP1 1889.217043 1528.367994 2250.066093 1.472201788 0.557975429 0.018658621 0.78509734 25.2448749 36.54363482 10605 poly(A) binding protein interacting protein 1 "GO:0003723,GO:0005515,GO:0005737,GO:0005829,GO:0006413,GO:0006446,GO:0008494,GO:0045727,GO:0048255" RNA binding|protein binding|cytoplasm|cytosol|translational initiation|regulation of translational initiation|translation activator activity|positive regulation of translation|mRNA stabilization hsa03013 RNA transport PAIP2 2379.244379 2129.727218 2628.76154 1.234318422 0.303714621 0.198893802 1 39.38310026 47.79784214 51247 poly(A) binding protein interacting protein 2 "GO:0000900,GO:0003729,GO:0005515,GO:0005737,GO:0007283,GO:0007613,GO:0017148,GO:0030371,GO:0045947,GO:1900271" "translation repressor activity, mRNA regulatory element binding|mRNA binding|protein binding|cytoplasm|spermatogenesis|memory|negative regulation of translation|translation repressor activity|negative regulation of translational initiation|regulation of long-term synaptic potentiation" PAIP2B 187.5185318 166.4662212 208.5708425 1.252931922 0.325308028 0.386127613 1 1.364669167 1.681225745 400961 poly(A) binding protein interacting protein 2B "GO:0000900,GO:0005515,GO:0005737,GO:0017148,GO:0030371,GO:0045947" "translation repressor activity, mRNA regulatory element binding|protein binding|cytoplasm|negative regulation of translation|translation repressor activity|negative regulation of translational initiation" PAK1 2505.303035 2360.6991 2649.906971 1.122509417 0.166727548 0.481062794 1 28.21638794 31.14315373 5058 p21 (RAC1) activated kinase 1 "GO:0000165,GO:0001666,GO:0001726,GO:0001934,GO:0002223,GO:0004672,GO:0004674,GO:0005515,GO:0005518,GO:0005524,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0005884,GO:0005886,GO:0005911,GO:0005925,GO:0006338,GO:0006468,GO:0006887,GO:0006915,GO:0006974,GO:0007165,GO:0008284,GO:0010763,GO:0014704,GO:0016477,GO:0019901,GO:0021549,GO:0030010,GO:0030018,GO:0030027,GO:0030335,GO:0030424,GO:0030425,GO:0031098,GO:0031116,GO:0031267,GO:0031295,GO:0031532,GO:0031965,GO:0032147,GO:0032587,GO:0032869,GO:0032991,GO:0033138,GO:0033148,GO:0038095,GO:0038096,GO:0042060,GO:0043507,GO:0045773,GO:0046628,GO:0046777,GO:0048012,GO:0048013,GO:0048754,GO:0048812,GO:0050770,GO:0050852,GO:0051496,GO:0060244,GO:0061052,GO:0071437,GO:0090314,GO:0106310,GO:0106311,GO:1904707,GO:1904754" MAPK cascade|response to hypoxia|ruffle|positive regulation of protein phosphorylation|stimulatory C-type lectin receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|protein binding|collagen binding|ATP binding|nucleoplasm|chromosome|cytoplasm|cytosol|actin filament|plasma membrane|cell-cell junction|focal adhesion|chromatin remodeling|protein phosphorylation|exocytosis|apoptotic process|cellular response to DNA damage stimulus|signal transduction|positive regulation of cell population proliferation|positive regulation of fibroblast migration|intercalated disc|cell migration|protein kinase binding|cerebellum development|establishment of cell polarity|Z disc|lamellipodium|positive regulation of cell migration|axon|dendrite|stress-activated protein kinase signaling cascade|positive regulation of microtubule polymerization|small GTPase binding|T cell costimulation|actin cytoskeleton reorganization|nuclear membrane|activation of protein kinase activity|ruffle membrane|cellular response to insulin stimulus|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|positive regulation of intracellular estrogen receptor signaling pathway|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|wound healing|positive regulation of JUN kinase activity|positive regulation of axon extension|positive regulation of insulin receptor signaling pathway|protein autophosphorylation|hepatocyte growth factor receptor signaling pathway|ephrin receptor signaling pathway|branching morphogenesis of an epithelial tube|neuron projection morphogenesis|regulation of axonogenesis|T cell receptor signaling pathway|positive regulation of stress fiber assembly|negative regulation of cell proliferation involved in contact inhibition|negative regulation of cell growth involved in cardiac muscle cell development|invadopodium|positive regulation of protein targeting to membrane|protein serine kinase activity|protein threonine kinase activity|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of vascular associated smooth muscle cell migration "hsa04010,hsa04012,hsa04014,hsa04024,hsa04062,hsa04360,hsa04392,hsa04510,hsa04625,hsa04650,hsa04660,hsa04666,hsa04810,hsa05120,hsa05130,hsa05132,hsa05170,hsa05205,hsa05211" MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Axon guidance|Hippo signaling pathway - multiple species|Focal adhesion|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Salmonella infection|Human immunodeficiency virus 1 infection|Proteoglycans in cancer|Renal cell carcinoma PAK1IP1 515.1117395 565.9851522 464.2383267 0.820230575 -0.285898572 0.29291745 1 15.29396827 12.33466382 55003 PAK1 interacting protein 1 "GO:0005515,GO:0005730,GO:0008283,GO:0009968,GO:0042273,GO:0060021,GO:1901796" protein binding|nucleolus|cell population proliferation|negative regulation of signal transduction|ribosomal large subunit biogenesis|roof of mouth development|regulation of signal transduction by p53 class mediator PAK2 3275.06957 3253.374211 3296.764929 1.013337143 0.019114247 0.937075907 1 28.15414338 28.05223434 5062 p21 (RAC1) activated kinase 2 "GO:0002223,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0006468,GO:0006469,GO:0006915,GO:0007165,GO:0014069,GO:0016310,GO:0018105,GO:0019901,GO:0030296,GO:0031098,GO:0031267,GO:0031295,GO:0032147,GO:0034333,GO:0035722,GO:0038095,GO:0040008,GO:0042802,GO:0043066,GO:0045296,GO:0046777,GO:0048010,GO:0048471,GO:0050690,GO:0050731,GO:0050770,GO:0050852,GO:0051493,GO:0051497,GO:0060996,GO:0061098,GO:0070830,GO:0071407,GO:0098978,GO:0106310,GO:0106311,GO:0150105,GO:2001238,GO:2001271" stimulatory C-type lectin receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|cell-cell junction|protein phosphorylation|negative regulation of protein kinase activity|apoptotic process|signal transduction|postsynaptic density|phosphorylation|peptidyl-serine phosphorylation|protein kinase binding|protein tyrosine kinase activator activity|stress-activated protein kinase signaling cascade|small GTPase binding|T cell costimulation|activation of protein kinase activity|adherens junction assembly|interleukin-12-mediated signaling pathway|Fc-epsilon receptor signaling pathway|regulation of growth|identical protein binding|negative regulation of apoptotic process|cadherin binding|protein autophosphorylation|vascular endothelial growth factor receptor signaling pathway|perinuclear region of cytoplasm|regulation of defense response to virus by virus|positive regulation of peptidyl-tyrosine phosphorylation|regulation of axonogenesis|T cell receptor signaling pathway|regulation of cytoskeleton organization|negative regulation of stress fiber assembly|dendritic spine development|positive regulation of protein tyrosine kinase activity|bicellular tight junction assembly|cellular response to organic cyclic compound|glutamatergic synapse|protein serine kinase activity|protein threonine kinase activity|protein localization to cell-cell junction|positive regulation of extrinsic apoptotic signaling pathway|negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis "hsa04010,hsa04012,hsa04014,hsa04360,hsa04510,hsa04660,hsa04810,hsa05130,hsa05170,hsa05211" MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Axon guidance|Focal adhesion|T cell receptor signaling pathway|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Human immunodeficiency virus 1 infection|Renal cell carcinoma PAK3 422.4350316 479.6307999 365.2392633 0.761500853 -0.393082442 0.16772985 1 2.068445597 1.548765535 5063 p21 (RAC1) activated kinase 3 "GO:0000165,GO:0000187,GO:0002223,GO:0004674,GO:0004708,GO:0005515,GO:0005524,GO:0005737,GO:0005768,GO:0005829,GO:0005886,GO:0006468,GO:0007165,GO:0007409,GO:0010763,GO:0014069,GO:0016358,GO:0017124,GO:0030833,GO:0031098,GO:0031267,GO:0031295,GO:0032147,GO:0043525,GO:0046872,GO:0048013,GO:0050770,GO:0050808,GO:0050852,GO:0060997,GO:0061003,GO:0071407,GO:0098978,GO:0106310,GO:0106311,GO:2000573" MAPK cascade|activation of MAPK activity|stimulatory C-type lectin receptor signaling pathway|protein serine/threonine kinase activity|MAP kinase kinase activity|protein binding|ATP binding|cytoplasm|endosome|cytosol|plasma membrane|protein phosphorylation|signal transduction|axonogenesis|positive regulation of fibroblast migration|postsynaptic density|dendrite development|SH3 domain binding|regulation of actin filament polymerization|stress-activated protein kinase signaling cascade|small GTPase binding|T cell costimulation|activation of protein kinase activity|positive regulation of neuron apoptotic process|metal ion binding|ephrin receptor signaling pathway|regulation of axonogenesis|synapse organization|T cell receptor signaling pathway|dendritic spine morphogenesis|positive regulation of dendritic spine morphogenesis|cellular response to organic cyclic compound|glutamatergic synapse|protein serine kinase activity|protein threonine kinase activity|positive regulation of DNA biosynthetic process "hsa04012,hsa04014,hsa04360,hsa04510,hsa04660,hsa04810,hsa05130,hsa05132,hsa05170,hsa05211" ErbB signaling pathway|Ras signaling pathway|Axon guidance|Focal adhesion|T cell receptor signaling pathway|Regulation of actin cytoskeleton|Pathogenic Escherichia coli infection|Salmonella infection|Human immunodeficiency virus 1 infection|Renal cell carcinoma PAK4 1097.673587 1010.24188 1185.105294 1.17309064 0.230314489 0.345530549 1 15.2776289 17.62214234 10298 p21 (RAC1) activated kinase 4 "GO:0001558,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005794,GO:0005912,GO:0005925,GO:0006468,GO:0006915,GO:0007010,GO:0007049,GO:0007165,GO:0016477,GO:0031098,GO:0032147,GO:0045766,GO:0060996,GO:0071407,GO:0098609,GO:0098641,GO:0106310,GO:0106311,GO:2000352" regulation of cell growth|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|Golgi apparatus|adherens junction|focal adhesion|protein phosphorylation|apoptotic process|cytoskeleton organization|cell cycle|signal transduction|cell migration|stress-activated protein kinase signaling cascade|activation of protein kinase activity|positive regulation of angiogenesis|dendritic spine development|cellular response to organic cyclic compound|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|protein serine kinase activity|protein threonine kinase activity|negative regulation of endothelial cell apoptotic process "hsa04012,hsa04014,hsa04360,hsa04510,hsa04660,hsa04810,hsa05170,hsa05206,hsa05211" ErbB signaling pathway|Ras signaling pathway|Axon guidance|Focal adhesion|T cell receptor signaling pathway|Regulation of actin cytoskeleton|Human immunodeficiency virus 1 infection|MicroRNAs in cancer|Renal cell carcinoma PALB2 582.1743899 610.7229491 553.6258307 0.906508969 -0.141606802 0.595816209 1 6.514723433 5.806832077 79728 partner and localizer of BRCA2 "GO:0000724,GO:0001756,GO:0001833,GO:0003677,GO:0005515,GO:0005654,GO:0007498,GO:0009887,GO:0035264,GO:0036342,GO:0043066,GO:0048568" double-strand break repair via homologous recombination|somitogenesis|inner cell mass cell proliferation|DNA binding|protein binding|nucleoplasm|mesoderm development|animal organ morphogenesis|multicellular organism growth|post-anal tail morphogenesis|negative regulation of apoptotic process|embryonic organ development "hsa03440,hsa03460" Homologous recombination|Fanconi anemia pathway other PALD1 6.326771641 2.080827765 10.57271552 5.081014245 2.345116509 0.135588131 1 0.018216856 0.091011236 27143 phosphatase domain containing paladin 1 "GO:0004725,GO:0005515,GO:0005737,GO:0005829,GO:0035335" protein tyrosine phosphatase activity|protein binding|cytoplasm|cytosol|peptidyl-tyrosine dephosphorylation PALLD 1873.02842 1948.695202 1797.361638 0.92234108 -0.116627739 0.623601243 1 10.8682497 9.856491202 23022 "palladin, cytoskeletal associated protein" "GO:0001725,GO:0001726,GO:0002102,GO:0003334,GO:0003382,GO:0003779,GO:0005515,GO:0005634,GO:0005829,GO:0005884,GO:0005886,GO:0005925,GO:0007010,GO:0007156,GO:0007411,GO:0015629,GO:0016477,GO:0030018,GO:0030027,GO:0030036,GO:0030424,GO:0030426,GO:0051371,GO:0060076,GO:0070593,GO:0098632" stress fiber|ruffle|podosome|keratinocyte development|epithelial cell morphogenesis|actin binding|protein binding|nucleus|cytosol|actin filament|plasma membrane|focal adhesion|cytoskeleton organization|homophilic cell adhesion via plasma membrane adhesion molecules|axon guidance|actin cytoskeleton|cell migration|Z disc|lamellipodium|actin cytoskeleton organization|axon|growth cone|muscle alpha-actinin binding|excitatory synapse|dendrite self-avoidance|cell-cell adhesion mediator activity PALM 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.045228056 0 5064 paralemmin "GO:0005515,GO:0005654,GO:0005886,GO:0007010,GO:0007193,GO:0007194,GO:0008360,GO:0014069,GO:0016323,GO:0016327,GO:0030424,GO:0031235,GO:0031410,GO:0031527,GO:0031750,GO:0032591,GO:0051491,GO:0060074,GO:0060160,GO:0071257,GO:0072659" protein binding|nucleoplasm|plasma membrane|cytoskeleton organization|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|regulation of cell shape|postsynaptic density|basolateral plasma membrane|apicolateral plasma membrane|axon|intrinsic component of the cytoplasmic side of the plasma membrane|cytoplasmic vesicle|filopodium membrane|D3 dopamine receptor binding|dendritic spine membrane|positive regulation of filopodium assembly|synapse maturation|negative regulation of dopamine receptor signaling pathway|cellular response to electrical stimulus|protein localization to plasma membrane PALM2AKAP2 10205.91087 10544.5947 9867.227044 0.935761622 -0.095787033 0.703766936 1 33.41124734 30.74178621 445815 PALM2 and AKAP2 fusion "GO:0005515,GO:0005886,GO:0008360" protein binding|plasma membrane|regulation of cell shape PALM3 49.20200732 42.65696919 55.74704545 1.306868409 0.386113881 0.537311161 1 0.872900324 1.121676686 342979 paralemmin 3 "GO:0001960,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0008063,GO:0032496" negative regulation of cytokine-mediated signaling pathway|protein binding|ATP binding|cytoplasm|plasma membrane|Toll signaling pathway|response to lipopolysaccharide PALS1 1674.913249 1642.813521 1707.012978 1.039078968 0.055305301 0.818090613 1 15.18163433 15.51094506 64398 "protein associated with LIN7 1, MAGUK family member" PALS2 713.9313994 713.7239235 714.1388753 1.00058139 0.000838524 1 1 4.151965776 4.084861769 51678 "protein associated with LIN7 2, MAGUK family member" PAM 4990.699198 4728.681097 5252.7173 1.110820796 0.151626092 0.527783245 1 52.66298397 57.52023392 5066 peptidylglycine alpha-amidating monooxygenase "GO:0001519,GO:0001666,GO:0001676,GO:0004504,GO:0004598,GO:0005507,GO:0005509,GO:0005515,GO:0005576,GO:0005802,GO:0005886,GO:0006357,GO:0007417,GO:0007507,GO:0007595,GO:0008270,GO:0009268,GO:0009404,GO:0009986,GO:0010043,GO:0016020,GO:0016021,GO:0018032,GO:0018215,GO:0019901,GO:0022602,GO:0030658,GO:0030667,GO:0031418,GO:0032355,GO:0032956,GO:0042476,GO:0042493,GO:0042802,GO:0043005,GO:0043204,GO:0046688,GO:0048471,GO:0050708,GO:0051384,GO:0055114,GO:0060135,GO:0060173,GO:0062112,GO:0070062" peptide amidation|response to hypoxia|long-chain fatty acid metabolic process|peptidylglycine monooxygenase activity|peptidylamidoglycolate lyase activity|copper ion binding|calcium ion binding|protein binding|extracellular region|trans-Golgi network|plasma membrane|regulation of transcription by RNA polymerase II|central nervous system development|heart development|lactation|zinc ion binding|response to pH|toxin metabolic process|cell surface|response to zinc ion|membrane|integral component of membrane|protein amidation|protein phosphopantetheinylation|protein kinase binding|ovulation cycle process|transport vesicle membrane|secretory granule membrane|L-ascorbic acid binding|response to estradiol|regulation of actin cytoskeleton organization|odontogenesis|response to drug|identical protein binding|neuron projection|perikaryon|response to copper ion|perinuclear region of cytoplasm|regulation of protein secretion|response to glucocorticoid|oxidation-reduction process|maternal process involved in female pregnancy|limb development|fatty acid primary amide biosynthetic process|extracellular exosome PAM16 2.561405743 4.161655531 0.961155956 0.230955193 -2.11431511 0.482263142 1 0.416697761 0.094628091 51025 presequence translocase associated motor 16 "GO:0001405,GO:0001503,GO:0005515,GO:0005744,GO:0005759,GO:0030150,GO:0031314,GO:0032780,GO:0032991" "PAM complex, Tim23 associated import motor|ossification|protein binding|TIM23 mitochondrial import inner membrane translocase complex|mitochondrial matrix|protein import into mitochondrial matrix|extrinsic component of mitochondrial inner membrane|negative regulation of ATPase activity|protein-containing complex" PAN2 669.4307618 731.4109595 607.4505642 0.830518816 -0.267915241 0.299602495 1 7.1230034 5.816795645 9924 poly(A) specific ribonuclease subunit PAN2 "GO:0000175,GO:0000289,GO:0000932,GO:0003676,GO:0004535,GO:0004843,GO:0005515,GO:0005634,GO:0005829,GO:0006397,GO:0006508,GO:0010606,GO:0018215,GO:0031251,GO:0046872,GO:0090503" "3'-5'-exoribonuclease activity|nuclear-transcribed mRNA poly(A) tail shortening|P-body|nucleic acid binding|poly(A)-specific ribonuclease activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytosol|mRNA processing|proteolysis|positive regulation of cytoplasmic mRNA processing body assembly|protein phosphopantetheinylation|PAN complex|metal ion binding|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation PAN3 783.0503399 724.1280623 841.9726175 1.162739937 0.217528454 0.389753485 1 3.493210141 3.993727975 255967 poly(A) specific ribonuclease subunit PAN3 "GO:0000289,GO:0000932,GO:0003723,GO:0004535,GO:0004672,GO:0005515,GO:0005524,GO:0005829,GO:0006397,GO:0006468,GO:0031251,GO:0046872,GO:0090503" "nuclear-transcribed mRNA poly(A) tail shortening|P-body|RNA binding|poly(A)-specific ribonuclease activity|protein kinase activity|protein binding|ATP binding|cytosol|mRNA processing|protein phosphorylation|PAN complex|metal ion binding|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03018 RNA degradation PANK1 252.2720272 276.7500928 227.7939616 0.82310347 -0.280854297 0.403247624 1 1.531644074 1.239605418 53354 pantothenate kinase 1 "GO:0004594,GO:0005524,GO:0005634,GO:0005829,GO:0015937,GO:0016310,GO:0042803,GO:1905502" pantothenate kinase activity|ATP binding|nucleus|cytosol|coenzyme A biosynthetic process|phosphorylation|protein homodimerization activity|acetyl-CoA binding hsa00770 Pantothenate and CoA biosynthesis PANK2 790.56095 769.9062732 811.2156269 1.053655042 0.075402618 0.768838259 1 4.695826602 4.864986957 80025 pantothenate kinase 2 "GO:0004594,GO:0005524,GO:0005634,GO:0005739,GO:0005758,GO:0005829,GO:0007286,GO:0009060,GO:0015937,GO:0015939,GO:0016310,GO:0019217,GO:0051881,GO:0070584,GO:0090207,GO:1904251" pantothenate kinase activity|ATP binding|nucleus|mitochondrion|mitochondrial intermembrane space|cytosol|spermatid development|aerobic respiration|coenzyme A biosynthetic process|pantothenate metabolic process|phosphorylation|regulation of fatty acid metabolic process|regulation of mitochondrial membrane potential|mitochondrion morphogenesis|regulation of triglyceride metabolic process|regulation of bile acid metabolic process hsa00770 Pantothenate and CoA biosynthesis PANK3 1519.121696 1653.21766 1385.025733 0.837775791 -0.255363899 0.284440393 1 8.587618065 7.074108329 79646 pantothenate kinase 3 "GO:0004594,GO:0005524,GO:0005634,GO:0005829,GO:0015937,GO:0016310,GO:0019842,GO:0042803,GO:1905502" pantothenate kinase activity|ATP binding|nucleus|cytosol|coenzyme A biosynthetic process|phosphorylation|vitamin binding|protein homodimerization activity|acetyl-CoA binding hsa00770 Pantothenate and CoA biosynthesis PANK4 806.9358142 682.511507 931.3601214 1.364607207 0.448485741 0.074435198 1 8.172399535 10.96549976 55229 pantothenate kinase 4 (inactive) "GO:0004594,GO:0005524,GO:0005634,GO:0005829,GO:0015937,GO:0016310,GO:0016787,GO:0046872" pantothenate kinase activity|ATP binding|nucleus|cytosol|coenzyme A biosynthetic process|phosphorylation|hydrolase activity|metal ion binding PANO1 4.444088692 3.121241648 5.766935736 1.847641543 0.88568489 0.705170935 1 0.065400444 0.11881454 101927423 "GO:0005730,GO:0006915,GO:0031647,GO:0032435,GO:0043065" nucleolus|apoptotic process|regulation of protein stability|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of apoptotic process PANX1 1434.694686 1468.023988 1401.365384 0.954592973 -0.067042378 0.78157309 1 11.64819241 10.93321649 24145 pannexin 1 "GO:0002020,GO:0002931,GO:0005102,GO:0005198,GO:0005262,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0005921,GO:0006812,GO:0006816,GO:0007267,GO:0016020,GO:0016021,GO:0022829,GO:0022840,GO:0032059,GO:0032730,GO:0032731,GO:0032991,GO:0033198,GO:0044325,GO:0048477,GO:0051015,GO:0055077,GO:0070588,GO:0097110" protease binding|response to ischemia|signaling receptor binding|structural molecule activity|calcium channel activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|gap junction|cation transport|calcium ion transport|cell-cell signaling|membrane|integral component of membrane|wide pore channel activity|leak channel activity|bleb|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-1 beta production|protein-containing complex|response to ATP|ion channel binding|oogenesis|actin filament binding|gap junction hemi-channel activity|calcium ion transmembrane transport|scaffold protein binding hsa04621 NOD-like receptor signaling pathway PANX2 304.8877701 295.4775427 314.2979976 1.063695044 0.089084596 0.78487422 1 5.314827566 5.558754487 56666 pannexin 2 "GO:0002931,GO:0005198,GO:0005737,GO:0005886,GO:0005921,GO:0006812,GO:0007267,GO:0016021,GO:0022829,GO:0032732,GO:0055077,GO:0055085" response to ischemia|structural molecule activity|cytoplasm|plasma membrane|gap junction|cation transport|cell-cell signaling|integral component of membrane|wide pore channel activity|positive regulation of interleukin-1 production|gap junction hemi-channel activity|transmembrane transport PAOX 95.88223786 82.19269673 109.571779 1.333108455 0.414794156 0.387893987 1 2.396979869 3.141962868 196743 polyamine oxidase "GO:0005782,GO:0005829,GO:0006596,GO:0006625,GO:0009446,GO:0009447,GO:0016491,GO:0046203,GO:0046208,GO:0046592,GO:0052899,GO:0052901,GO:0052902,GO:0052903,GO:0052904,GO:0055114,GO:1901307" "peroxisomal matrix|cytosol|polyamine biosynthetic process|protein targeting to peroxisome|putrescine biosynthetic process|putrescine catabolic process|oxidoreductase activity|spermidine catabolic process|spermine catabolic process|polyamine oxidase activity|N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity|spermine:oxygen oxidoreductase (spermidine-forming) activity|spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity|N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity|N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity|oxidation-reduction process|positive regulation of spermidine biosynthetic process" hsa04146 Peroxisome PAPLN 491.4099331 549.33853 433.4813362 0.789096909 -0.341725606 0.213166973 1 4.747722706 3.68372216 89932 "papilin, proteoglycan like sulfated glycoprotein" "GO:0004222,GO:0004867,GO:0006508,GO:0010951,GO:0030198,GO:0031012" metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|proteolysis|negative regulation of endopeptidase activity|extracellular matrix organization|extracellular matrix PAPOLA 4116.927832 4133.564356 4100.291308 0.991950519 -0.011659938 0.962078749 1 47.69745567 46.5217883 10914 poly(A) polymerase alpha "GO:0000287,GO:0000398,GO:0003723,GO:0004652,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006369,GO:0006378,GO:0030145,GO:0031124,GO:0031440,GO:0043631" "magnesium ion binding|mRNA splicing, via spliceosome|RNA binding|polynucleotide adenylyltransferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|termination of RNA polymerase II transcription|mRNA polyadenylation|manganese ion binding|mRNA 3'-end processing|regulation of mRNA 3'-end processing|RNA polyadenylation" hsa03015 mRNA surveillance pathway PAPOLG 500.516377 510.8432164 490.1895376 0.959569437 -0.059540887 0.834175265 1 3.700157922 3.491144667 64895 poly(A) polymerase gamma "GO:0003723,GO:0004652,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006378,GO:0016020,GO:0016604,GO:0043631,GO:0046872" RNA binding|polynucleotide adenylyltransferase activity|ATP binding|nucleus|nucleoplasm|cytosol|mRNA polyadenylation|membrane|nuclear body|RNA polyadenylation|metal ion binding hsa03015 mRNA surveillance pathway PAPPA 11.32566582 19.76786377 2.883467868 0.145866438 -2.777280123 0.019291268 0.804292972 0.095819669 0.01374299 5069 pappalysin 1 "GO:0004222,GO:0005515,GO:0005576,GO:0005615,GO:0006508,GO:0007565,GO:0008237,GO:0008270,GO:0032354,GO:0044267,GO:0051384" metalloendopeptidase activity|protein binding|extracellular region|extracellular space|proteolysis|female pregnancy|metallopeptidase activity|zinc ion binding|response to follicle-stimulating hormone|cellular protein metabolic process|response to glucocorticoid PAPPA2 78.92803048 116.5263549 41.32970611 0.354681189 -1.495405277 0.003739773 0.381043789 0.554210622 0.193278782 60676 pappalysin 2 "GO:0001558,GO:0005576,GO:0005829,GO:0006508,GO:0008237,GO:0008270,GO:0009651,GO:0016324,GO:0044267,GO:0060349,GO:0070062" regulation of cell growth|extracellular region|cytosol|proteolysis|metallopeptidase activity|zinc ion binding|response to salt stress|apical plasma membrane|cellular protein metabolic process|bone morphogenesis|extracellular exosome PAPSS1 1719.176727 1517.963855 1920.3896 1.265108912 0.33926159 0.153034724 1 29.03617958 36.11923698 9061 3'-phosphoadenosine 5'-phosphosulfate synthase 1 "GO:0000103,GO:0001501,GO:0004020,GO:0004781,GO:0005524,GO:0005829,GO:0016310,GO:0016779,GO:0042803,GO:0050428" sulfate assimilation|skeletal system development|adenylylsulfate kinase activity|sulfate adenylyltransferase (ATP) activity|ATP binding|cytosol|phosphorylation|nucleotidyltransferase activity|protein homodimerization activity|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process "hsa00230,hsa00450,hsa00920" Purine metabolism|Selenocompound metabolism|Sulfur metabolism PAPSS2 3463.681393 3688.267214 3239.095572 0.878216079 -0.187352146 0.429978013 1 53.21331237 45.95077666 9060 3'-phosphoadenosine 5'-phosphosulfate synthase 2 "GO:0000103,GO:0001501,GO:0004020,GO:0004781,GO:0005515,GO:0005524,GO:0005829,GO:0016310,GO:0016779,GO:0050428" sulfate assimilation|skeletal system development|adenylylsulfate kinase activity|sulfate adenylyltransferase (ATP) activity|protein binding|ATP binding|cytosol|phosphorylation|nucleotidyltransferase activity|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process "hsa00230,hsa00450,hsa00920" Purine metabolism|Selenocompound metabolism|Sulfur metabolism PAQR3 1217.494176 1317.163975 1117.824377 0.848659998 -0.236741418 0.327988621 1 7.292729591 6.085482546 152559 progestin and adipoQ receptor family member 3 "GO:0000139,GO:0000165,GO:0001933,GO:0005515,GO:0005794,GO:0010977,GO:0016021,GO:0033137,GO:0034067,GO:0038023,GO:0043407" Golgi membrane|MAPK cascade|negative regulation of protein phosphorylation|protein binding|Golgi apparatus|negative regulation of neuron projection development|integral component of membrane|negative regulation of peptidyl-serine phosphorylation|protein localization to Golgi apparatus|signaling receptor activity|negative regulation of MAP kinase activity PAQR4 503.935143 474.4287305 533.4415556 1.124387124 0.169138837 0.538614667 1 11.06616669 12.23444434 124222 progestin and adipoQ receptor family member 4 "GO:0016021,GO:0038023" integral component of membrane|signaling receptor activity PAQR5 47.40864313 20.80827765 74.00900861 3.556709971 1.830543336 0.003746618 0.381043789 0.224162199 0.783938529 54852 progestin and adipoQ receptor family member 5 "GO:0005496,GO:0005515,GO:0005886,GO:0007275,GO:0016021,GO:0038023,GO:0048477" steroid binding|protein binding|plasma membrane|multicellular organism development|integral component of membrane|signaling receptor activity|oogenesis PAQR6 25.61908785 29.13158871 22.10658699 0.758852777 -0.398108076 0.63496867 1 0.704759451 0.525859367 79957 progestin and adipoQ receptor family member 6 "GO:0005496,GO:0005515,GO:0005886,GO:0016021,GO:0038023" steroid binding|protein binding|plasma membrane|integral component of membrane|signaling receptor activity PAQR7 422.584101 407.842242 437.32596 1.072291967 0.100697781 0.730143382 1 7.313773815 7.71126728 164091 progestin and adipoQ receptor family member 7 "GO:0003707,GO:0005496,GO:0005515,GO:0005886,GO:0007275,GO:0016021,GO:0038023,GO:0043401,GO:0048477,GO:0048545" steroid hormone receptor activity|steroid binding|protein binding|plasma membrane|multicellular organism development|integral component of membrane|signaling receptor activity|steroid hormone mediated signaling pathway|oogenesis|response to steroid hormone PAQR8 209.5307696 201.8402932 217.2212461 1.076203579 0.10595101 0.777894018 1 2.284590771 2.417542005 85315 progestin and adipoQ receptor family member 8 "GO:0003707,GO:0005496,GO:0005515,GO:0005794,GO:0005886,GO:0007275,GO:0016021,GO:0038023,GO:0043401,GO:0048477,GO:0048545" steroid hormone receptor activity|steroid binding|protein binding|Golgi apparatus|plasma membrane|multicellular organism development|integral component of membrane|signaling receptor activity|steroid hormone mediated signaling pathway|oogenesis|response to steroid hormone PAQR9 17.09260156 19.76786377 14.41733934 0.729332188 -0.455352028 0.654677017 1 0.096221685 0.069003246 344838 progestin and adipoQ receptor family member 9 "GO:0005496,GO:0005886,GO:0016021,GO:0038023" steroid binding|plasma membrane|integral component of membrane|signaling receptor activity PARD3 1200.853813 1069.545471 1332.162155 1.245540457 0.316771883 0.190849036 1 9.355790209 11.45801778 56288 par-3 family cell polarity regulator "GO:0000226,GO:0005515,GO:0005546,GO:0005547,GO:0005829,GO:0005856,GO:0005886,GO:0005911,GO:0005912,GO:0005923,GO:0005938,GO:0006612,GO:0007049,GO:0007155,GO:0007163,GO:0007179,GO:0007205,GO:0007409,GO:0008104,GO:0008356,GO:0010801,GO:0012505,GO:0016324,GO:0019903,GO:0022011,GO:0030010,GO:0030054,GO:0031643,GO:0032266,GO:0032991,GO:0033269,GO:0035091,GO:0042802,GO:0043025,GO:0043296,GO:0044295,GO:0045197,GO:0051660,GO:0060341,GO:0065003,GO:0070830,GO:0090162" "microtubule cytoskeleton organization|protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytosol|cytoskeleton|plasma membrane|cell-cell junction|adherens junction|bicellular tight junction|cell cortex|protein targeting to membrane|cell cycle|cell adhesion|establishment or maintenance of cell polarity|transforming growth factor beta receptor signaling pathway|protein kinase C-activating G protein-coupled receptor signaling pathway|axonogenesis|protein localization|asymmetric cell division|negative regulation of peptidyl-threonine phosphorylation|endomembrane system|apical plasma membrane|protein phosphatase binding|myelination in peripheral nervous system|establishment of cell polarity|cell junction|positive regulation of myelination|phosphatidylinositol-3-phosphate binding|protein-containing complex|internode region of axon|phosphatidylinositol binding|identical protein binding|neuronal cell body|apical junction complex|axonal growth cone|establishment or maintenance of epithelial cell apical/basal polarity|establishment of centrosome localization|regulation of cellular localization|protein-containing complex assembly|bicellular tight junction assembly|establishment of epithelial cell polarity" "hsa04015,hsa04062,hsa04080,hsa04144,hsa04360,hsa04390,hsa04520,hsa04530,hsa05165" Rap1 signaling pathway|Chemokine signaling pathway|Neuroactive ligand-receptor interaction|Endocytosis|Axon guidance|Hippo signaling pathway|Adherens junction|Tight junction|Human papillomavirus infection PARD3B 133.7780866 156.0620824 111.4940909 0.714421397 -0.485152805 0.252347858 1 0.347726558 0.244266266 117583 par-3 family cell polarity regulator beta "GO:0000226,GO:0005515,GO:0005912,GO:0005923,GO:0005938,GO:0007049,GO:0007155,GO:0008104,GO:0012505,GO:0016324,GO:0030010,GO:0030054,GO:0032991,GO:0035091,GO:0043296,GO:0045197,GO:0051301,GO:0051660" microtubule cytoskeleton organization|protein binding|adherens junction|bicellular tight junction|cell cortex|cell cycle|cell adhesion|protein localization|endomembrane system|apical plasma membrane|establishment of cell polarity|cell junction|protein-containing complex|phosphatidylinositol binding|apical junction complex|establishment or maintenance of epithelial cell apical/basal polarity|cell division|establishment of centrosome localization PARD6A 42.71168941 48.89945248 36.52392633 0.746918922 -0.420976448 0.522476056 1 2.086070268 1.532052238 50855 par-6 family cell polarity regulator alpha "GO:0001726,GO:0001933,GO:0005080,GO:0005515,GO:0005634,GO:0005813,GO:0005829,GO:0005886,GO:0005923,GO:0005938,GO:0007098,GO:0007163,GO:0007179,GO:0008134,GO:0016032,GO:0016324,GO:0030742,GO:0031267,GO:0034451,GO:0045217,GO:0050714,GO:0051301,GO:0060071,GO:0060341,GO:0070830,GO:1904781" "ruffle|negative regulation of protein phosphorylation|protein kinase C binding|protein binding|nucleus|centrosome|cytosol|plasma membrane|bicellular tight junction|cell cortex|centrosome cycle|establishment or maintenance of cell polarity|transforming growth factor beta receptor signaling pathway|transcription factor binding|viral process|apical plasma membrane|GTP-dependent protein binding|small GTPase binding|centriolar satellite|cell-cell junction maintenance|positive regulation of protein secretion|cell division|Wnt signaling pathway, planar cell polarity pathway|regulation of cellular localization|bicellular tight junction assembly|positive regulation of protein localization to centrosome" "hsa04015,hsa04144,hsa04360,hsa04390,hsa04530,hsa05165" Rap1 signaling pathway|Endocytosis|Axon guidance|Hippo signaling pathway|Tight junction|Human papillomavirus infection PARD6B 157.7277276 153.9812546 161.4742006 1.048661417 0.068548947 0.879004848 1 1.794648734 1.850486516 84612 par-6 family cell polarity regulator beta "GO:0005080,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0005923,GO:0005938,GO:0007043,GO:0007098,GO:0007163,GO:0007409,GO:0016324,GO:0030334,GO:0032991,GO:0051301,GO:0060341,GO:0065003,GO:0070062,GO:0070830" protein kinase C binding|protein binding|nucleus|cytosol|plasma membrane|bicellular tight junction|cell cortex|cell-cell junction assembly|centrosome cycle|establishment or maintenance of cell polarity|axonogenesis|apical plasma membrane|regulation of cell migration|protein-containing complex|cell division|regulation of cellular localization|protein-containing complex assembly|extracellular exosome|bicellular tight junction assembly "hsa04015,hsa04144,hsa04360,hsa04390,hsa04530,hsa05165" Rap1 signaling pathway|Endocytosis|Axon guidance|Hippo signaling pathway|Tight junction|Human papillomavirus infection PARD6G 346.2571052 296.5179566 395.9962539 1.335488274 0.417367308 0.166239995 1 4.125291544 5.417088168 84552 par-6 family cell polarity regulator gamma "GO:0005080,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0005923,GO:0005938,GO:0007098,GO:0007163,GO:0016324,GO:0032991,GO:0051301,GO:0060341,GO:0070830" protein kinase C binding|protein binding|nucleus|cytosol|plasma membrane|bicellular tight junction|cell cortex|centrosome cycle|establishment or maintenance of cell polarity|apical plasma membrane|protein-containing complex|cell division|regulation of cellular localization|bicellular tight junction assembly "hsa04015,hsa04144,hsa04360,hsa04390,hsa04530,hsa05165" Rap1 signaling pathway|Endocytosis|Axon guidance|Hippo signaling pathway|Tight junction|Human papillomavirus infection PARG 778.2093472 811.5228285 744.8958659 0.917898844 -0.123592924 0.627386834 1 9.83189145 8.873665966 8505 poly(ADP-ribose) glycohydrolase "GO:0004649,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005759,GO:0005829,GO:0005975,GO:0006282,GO:0006974,GO:0009225,GO:0031056,GO:0043231,GO:1990966" poly(ADP-ribose) glycohydrolase activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrial matrix|cytosol|carbohydrate metabolic process|regulation of DNA repair|cellular response to DNA damage stimulus|nucleotide-sugar metabolic process|regulation of histone modification|intracellular membrane-bounded organelle|ATP generation from poly-ADP-D-ribose PARK7 3616.775604 3215.919311 4017.631896 1.249294994 0.321114178 0.176513129 1 170.6040786 209.5682987 11315 Parkinsonism associated deglycase "GO:0000785,GO:0001046,GO:0001933,GO:0002866,GO:0003690,GO:0003697,GO:0003713,GO:0003729,GO:0005102,GO:0005507,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005758,GO:0005759,GO:0005783,GO:0005829,GO:0005886,GO:0005912,GO:0006281,GO:0006469,GO:0006508,GO:0006517,GO:0006914,GO:0006954,GO:0007005,GO:0007265,GO:0007338,GO:0008134,GO:0008233,GO:0008344,GO:0009438,GO:0010273,GO:0010628,GO:0010629,GO:0016532,GO:0016570,GO:0016605,GO:0016684,GO:0019249,GO:0019826,GO:0019899,GO:0019900,GO:0019955,GO:0030073,GO:0030424,GO:0031334,GO:0031397,GO:0032091,GO:0032148,GO:0032435,GO:0032679,GO:0032757,GO:0033138,GO:0033182,GO:0033234,GO:0033864,GO:0034599,GO:0035065,GO:0036470,GO:0036471,GO:0036478,GO:0036524,GO:0036526,GO:0036527,GO:0036528,GO:0036529,GO:0036530,GO:0036531,GO:0042593,GO:0042743,GO:0042802,GO:0042803,GO:0043066,GO:0043523,GO:0043524,GO:0044297,GO:0044388,GO:0044390,GO:0044877,GO:0045121,GO:0045296,GO:0045340,GO:0045944,GO:0046295,GO:0046826,GO:0048471,GO:0050681,GO:0050727,GO:0050787,GO:0050821,GO:0051091,GO:0051444,GO:0051583,GO:0051881,GO:0051897,GO:0051899,GO:0051920,GO:0055114,GO:0060081,GO:0060548,GO:0060765,GO:0061727,GO:0070062,GO:0070301,GO:0070491,GO:0070994,GO:0097110,GO:0098793,GO:0098869,GO:0106044,GO:0106045,GO:0106046,GO:0110095,GO:0140041,GO:1900182,GO:1901215,GO:1901671,GO:1901984,GO:1902177,GO:1902236,GO:1902903,GO:1902958,GO:1903073,GO:1903094,GO:1903122,GO:1903135,GO:1903136,GO:1903168,GO:1903178,GO:1903181,GO:1903189,GO:1903190,GO:1903197,GO:1903200,GO:1903202,GO:1903206,GO:1903208,GO:1903377,GO:1903384,GO:1903427,GO:1903428,GO:1903599,GO:1905259,GO:1990381,GO:1990422,GO:2000157,GO:2000277,GO:2000679,GO:2000825,GO:2001237,GO:2001268" "chromatin|core promoter sequence-specific DNA binding|negative regulation of protein phosphorylation|positive regulation of acute inflammatory response to antigenic stimulus|double-stranded DNA binding|single-stranded DNA binding|transcription coactivator activity|mRNA binding|signaling receptor binding|copper ion binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial intermembrane space|mitochondrial matrix|endoplasmic reticulum|cytosol|plasma membrane|adherens junction|DNA repair|negative regulation of protein kinase activity|proteolysis|protein deglycosylation|autophagy|inflammatory response|mitochondrion organization|Ras protein signal transduction|single fertilization|transcription factor binding|peptidase activity|adult locomotory behavior|methylglyoxal metabolic process|detoxification of copper ion|positive regulation of gene expression|negative regulation of gene expression|superoxide dismutase copper chaperone activity|histone modification|PML body|oxidoreductase activity, acting on peroxide as acceptor|lactate biosynthetic process|oxygen sensor activity|enzyme binding|kinase binding|cytokine binding|insulin secretion|axon|positive regulation of protein-containing complex assembly|negative regulation of protein ubiquitination|negative regulation of protein binding|activation of protein kinase B activity|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of TRAIL production|positive regulation of interleukin-8 production|positive regulation of peptidyl-serine phosphorylation|regulation of histone ubiquitination|negative regulation of protein sumoylation|positive regulation of NAD(P)H oxidase activity|cellular response to oxidative stress|regulation of histone acetylation|tyrosine 3-monooxygenase activator activity|cellular response to glyoxal|L-dopa decarboxylase activator activity|protein deglycase activity|peptidyl-cysteine deglycation|peptidyl-arginine deglycation|peptidyl-lysine deglycation|protein deglycation, glyoxal removal|protein deglycation, methylglyoxal removal|glutathione deglycation|glucose homeostasis|hydrogen peroxide metabolic process|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|regulation of neuron apoptotic process|negative regulation of neuron apoptotic process|cell body|small protein activating enzyme binding|ubiquitin-like protein conjugating enzyme binding|protein-containing complex binding|membrane raft|cadherin binding|mercury ion binding|positive regulation of transcription by RNA polymerase II|glycolate biosynthetic process|negative regulation of protein export from nucleus|perinuclear region of cytoplasm|androgen receptor binding|regulation of inflammatory response|detoxification of mercury ion|protein stabilization|positive regulation of DNA-binding transcription factor activity|negative regulation of ubiquitin-protein transferase activity|dopamine uptake involved in synaptic transmission|regulation of mitochondrial membrane potential|positive regulation of protein kinase B signaling|membrane depolarization|peroxiredoxin activity|oxidation-reduction process|membrane hyperpolarization|negative regulation of cell death|regulation of androgen receptor signaling pathway|methylglyoxal catabolic process to lactate|extracellular exosome|cellular response to hydrogen peroxide|repressing transcription factor binding|detection of oxidative stress|scaffold protein binding|presynapse|cellular oxidant detoxification|guanine deglycation|guanine deglycation, methylglyoxal removal|guanine deglycation, glyoxal removal|cellular detoxification of aldehyde|cellular detoxification of methylglyoxal|positive regulation of protein localization to nucleus|negative regulation of neuron death|positive regulation of superoxide dismutase activity|negative regulation of protein acetylation|positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|regulation of supramolecular fiber organization|positive regulation of mitochondrial electron transport, NADH to ubiquinone|negative regulation of death-inducing signaling complex assembly|negative regulation of protein K48-linked deubiquitination|negative regulation of TRAIL-activated apoptotic signaling pathway|cupric ion binding|cuprous ion binding|positive regulation of pyrroline-5-carboxylate reductase activity|positive regulation of tyrosine 3-monooxygenase activity|positive regulation of dopamine biosynthetic process|glyoxal metabolic process|glyoxal catabolic process|positive regulation of L-dopa biosynthetic process|positive regulation of L-dopa decarboxylase activity|negative regulation of oxidative stress-induced cell death|negative regulation of hydrogen peroxide-induced cell death|negative regulation of hydrogen peroxide-induced neuron death|negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway|negative regulation of reactive oxygen species biosynthetic process|positive regulation of reactive oxygen species biosynthetic process|positive regulation of autophagy of mitochondrion|negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway|ubiquitin-specific protease binding|glyoxalase (glycolic acid-forming) activity|negative regulation of ubiquitin-specific protease activity|positive regulation of oxidative phosphorylation uncoupler activity|positive regulation of transcription regulatory region DNA binding|positive regulation of androgen receptor activity|negative regulation of extrinsic apoptotic signaling pathway|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway" "hsa05012,hsa05022" Parkinson disease|Pathways of neurodegeneration - multiple diseases PARL 616.3847451 587.8338437 644.9356465 1.097139359 0.133746789 0.612768357 1 13.81400786 14.9022784 55486 presenilin associated rhomboid like "GO:0004175,GO:0004252,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0006508,GO:0006851,GO:0010821,GO:0016021,GO:0030162,GO:0033619,GO:1903214,GO:2000377" endopeptidase activity|serine-type endopeptidase activity|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|proteolysis|mitochondrial calcium ion transmembrane transport|regulation of mitochondrion organization|integral component of membrane|regulation of proteolysis|membrane protein proteolysis|regulation of protein targeting to mitochondrion|regulation of reactive oxygen species metabolic process PARM1 11.52884105 12.48496659 10.57271552 0.846835707 -0.239845992 0.903809209 1 0.130238413 0.108444976 25849 prostate androgen-regulated mucin-like protein 1 "GO:0000139,GO:0005515,GO:0005654,GO:0005769,GO:0005770,GO:0005794,GO:0005829,GO:0005886,GO:0010008,GO:0016021,GO:0043231,GO:0051973" Golgi membrane|protein binding|nucleoplasm|early endosome|late endosome|Golgi apparatus|cytosol|plasma membrane|endosome membrane|integral component of membrane|intracellular membrane-bounded organelle|positive regulation of telomerase activity PARN 901.3945966 1017.524777 785.264416 0.771739847 -0.373813497 0.132069968 1 12.46635152 9.45978949 5073 poly(A)-specific ribonuclease "GO:0000175,GO:0000184,GO:0000289,GO:0000495,GO:0003723,GO:0003730,GO:0004518,GO:0004535,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0007292,GO:0009451,GO:0010587,GO:0016607,GO:0019901,GO:0032212,GO:0043169,GO:0043488,GO:0046872,GO:0051973,GO:0070034,GO:0071051,GO:0090503,GO:0090669,GO:0110008,GO:1904872" "3'-5'-exoribonuclease activity|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|box H/ACA RNA 3'-end processing|RNA binding|mRNA 3'-UTR binding|nuclease activity|poly(A)-specific ribonuclease activity|protein binding|nucleus|nucleolus|cytoplasm|cytosol|female gamete generation|RNA modification|miRNA catabolic process|nuclear speck|protein kinase binding|positive regulation of telomere maintenance via telomerase|cation binding|regulation of mRNA stability|metal ion binding|positive regulation of telomerase activity|telomerase RNA binding|polyadenylation-dependent snoRNA 3'-end processing|RNA phosphodiester bond hydrolysis, exonucleolytic|telomerase RNA stabilization|ncRNA deadenylation|regulation of telomerase RNA localization to Cajal body" hsa03018 RNA degradation PARP1 4016.293306 4216.797466 3815.789145 0.904902162 -0.144166278 0.545266252 1 56.57182771 50.33534094 142 poly(ADP-ribose) polymerase 1 "GO:0000122,GO:0000715,GO:0000717,GO:0000723,GO:0000724,GO:0000781,GO:0003677,GO:0003723,GO:0003950,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005667,GO:0005730,GO:0005739,GO:0006281,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006302,GO:0006366,GO:0006471,GO:0006915,GO:0006974,GO:0007005,GO:0007179,GO:0008134,GO:0008270,GO:0010332,GO:0010613,GO:0010990,GO:0016020,GO:0016540,GO:0016604,GO:0018312,GO:0018424,GO:0019899,GO:0019901,GO:0023019,GO:0030225,GO:0030331,GO:0030592,GO:0032042,GO:0032869,GO:0032991,GO:0032993,GO:0033148,GO:0033683,GO:0034599,GO:0034644,GO:0035861,GO:0036211,GO:0042769,GO:0042802,GO:0042826,GO:0043504,GO:0044030,GO:0045944,GO:0047485,GO:0050790,GO:0051287,GO:0051901,GO:0060391,GO:0070212,GO:0070213,GO:0070412,GO:0070911,GO:0071294,GO:0090734,GO:0140294,GO:1900182,GO:1901216,GO:1903376,GO:1903518,GO:1903827,GO:1904044,GO:1904357,GO:1904646,GO:1904762,GO:1905168,GO:1990404,GO:1990966,GO:2000679,GO:2001170" "negative regulation of transcription by RNA polymerase II|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|telomere maintenance|double-strand break repair via homologous recombination|chromosome, telomeric region|DNA binding|RNA binding|NAD+ ADP-ribosyltransferase activity|protein binding|nucleus|nuclear envelope|nucleoplasm|transcription regulator complex|nucleolus|mitochondrion|DNA repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|double-strand break repair|transcription by RNA polymerase II|protein ADP-ribosylation|apoptotic process|cellular response to DNA damage stimulus|mitochondrion organization|transforming growth factor beta receptor signaling pathway|transcription factor binding|zinc ion binding|response to gamma radiation|positive regulation of cardiac muscle hypertrophy|regulation of SMAD protein complex assembly|membrane|protein autoprocessing|nuclear body|peptidyl-serine ADP-ribosylation|peptidyl-glutamic acid poly-ADP-ribosylation|enzyme binding|protein kinase binding|signal transduction involved in regulation of gene expression|macrophage differentiation|estrogen receptor binding|DNA ADP-ribosylation|mitochondrial DNA metabolic process|cellular response to insulin stimulus|protein-containing complex|protein-DNA complex|positive regulation of intracellular estrogen receptor signaling pathway|nucleotide-excision repair, DNA incision|cellular response to oxidative stress|cellular response to UV|site of double-strand break|protein modification process|DNA damage response, detection of DNA damage|identical protein binding|histone deacetylase binding|mitochondrial DNA repair|regulation of DNA methylation|positive regulation of transcription by RNA polymerase II|protein N-terminus binding|regulation of catalytic activity|NAD binding|positive regulation of mitochondrial depolarization|positive regulation of SMAD protein signal transduction|protein poly-ADP-ribosylation|protein auto-ADP-ribosylation|R-SMAD binding|global genome nucleotide-excision repair|cellular response to zinc ion|site of DNA damage|NAD DNA ADP-ribosyltransferase activity|positive regulation of protein localization to nucleus|positive regulation of neuron death|regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|positive regulation of single strand break repair|regulation of cellular protein localization|response to aldosterone|negative regulation of telomere maintenance via telomere lengthening|cellular response to amyloid-beta|positive regulation of myofibroblast differentiation|positive regulation of double-strand break repair via homologous recombination|protein ADP-ribosylase activity|ATP generation from poly-ADP-D-ribose|positive regulation of transcription regulatory region DNA binding|negative regulation of ATP biosynthetic process" "hsa03410,hsa04064,hsa04210,hsa04217" Base excision repair|NF-kappa B signaling pathway|Apoptosis|Necroptosis PARP10 698.2604101 743.8959261 652.6248941 0.877306719 -0.188846777 0.462985733 1 11.42127686 9.852292415 84875 poly(ADP-ribose) polymerase family member 10 "GO:0003714,GO:0003950,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0006471,GO:0010629,GO:0010847,GO:0019985,GO:0032088,GO:0034356,GO:0045071,GO:0045892,GO:0048147,GO:0070212,GO:0070213,GO:0070530,GO:0140289,GO:1900045,GO:1990404" "transcription corepressor activity|NAD+ ADP-ribosyltransferase activity|protein binding|nucleus|nucleolus|cytoplasm|Golgi apparatus|cytosol|protein ADP-ribosylation|negative regulation of gene expression|regulation of chromatin assembly|translesion synthesis|negative regulation of NF-kappaB transcription factor activity|NAD biosynthesis via nicotinamide riboside salvage pathway|negative regulation of viral genome replication|negative regulation of transcription, DNA-templated|negative regulation of fibroblast proliferation|protein poly-ADP-ribosylation|protein auto-ADP-ribosylation|K63-linked polyubiquitin modification-dependent protein binding|protein mono-ADP-ribosylation|negative regulation of protein K63-linked ubiquitination|protein ADP-ribosylase activity" PARP11 275.1963455 235.1335375 315.2591536 1.34076643 0.423057932 0.192894297 1 2.382051013 3.140330549 57097 poly(ADP-ribose) polymerase family member 11 "GO:0003950,GO:0005635,GO:0005643,GO:0005654,GO:0005829,GO:0006998,GO:0007283,GO:0015031,GO:0016604,GO:0030154,GO:0051028,GO:0070213,GO:0140289,GO:1990404" NAD+ ADP-ribosyltransferase activity|nuclear envelope|nuclear pore|nucleoplasm|cytosol|nuclear envelope organization|spermatogenesis|protein transport|nuclear body|cell differentiation|mRNA transport|protein auto-ADP-ribosylation|protein mono-ADP-ribosylation|protein ADP-ribosylase activity PARP12 684.1997314 753.259651 615.1398118 0.816637146 -0.292232902 0.255975814 1 9.790570663 7.861552438 64761 poly(ADP-ribose) polymerase family member 12 "GO:0003723,GO:0003950,GO:0005634,GO:0046872,GO:0070213,GO:0140289,GO:1990404" RNA binding|NAD+ ADP-ribosyltransferase activity|nucleus|metal ion binding|protein auto-ADP-ribosylation|protein mono-ADP-ribosylation|protein ADP-ribosylase activity PARP14 1419.403666 1747.895323 1090.91201 0.624128914 -0.680084045 0.004579484 0.412329403 11.30279424 6.936354856 54625 poly(ADP-ribose) polymerase family member 14 "GO:0003714,GO:0003950,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006471,GO:0010629,GO:0016020,GO:0019899,GO:0042531,GO:0042532,GO:0045087,GO:0045892,GO:0060336,GO:0070212,GO:0140289,GO:1902216,GO:1990404" "transcription corepressor activity|NAD+ ADP-ribosyltransferase activity|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|protein ADP-ribosylation|negative regulation of gene expression|membrane|enzyme binding|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of tyrosine phosphorylation of STAT protein|innate immune response|negative regulation of transcription, DNA-templated|negative regulation of interferon-gamma-mediated signaling pathway|protein poly-ADP-ribosylation|protein mono-ADP-ribosylation|positive regulation of interleukin-4-mediated signaling pathway|protein ADP-ribosylase activity" PARP15 14.61045374 17.687036 11.53387147 0.65210878 -0.61681545 0.556527256 1 0.111720275 0.071634663 165631 poly(ADP-ribose) polymerase family member 15 "GO:0000122,GO:0003714,GO:0003950,GO:0005515,GO:0005634,GO:0005737,GO:0010629,GO:0070212,GO:0070403,GO:0140289,GO:1990404" negative regulation of transcription by RNA polymerase II|transcription corepressor activity|NAD+ ADP-ribosyltransferase activity|protein binding|nucleus|cytoplasm|negative regulation of gene expression|protein poly-ADP-ribosylation|NAD+ binding|protein mono-ADP-ribosylation|protein ADP-ribosylase activity PARP16 240.1141531 235.1335375 245.0947688 1.042364145 0.059859365 0.872151865 1 3.692950188 3.784984389 54956 poly(ADP-ribose) polymerase family member 16 "GO:0003950,GO:0005515,GO:0005622,GO:0005635,GO:0005783,GO:0005789,GO:0005829,GO:0006471,GO:0016020,GO:0016021,GO:0019900,GO:0030968,GO:0034356,GO:0036498,GO:0043539,GO:0060548,GO:0070213,GO:0071782,GO:0071902,GO:0140289,GO:1990404,GO:1990830" NAD+ ADP-ribosyltransferase activity|protein binding|intracellular anatomical structure|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|protein ADP-ribosylation|membrane|integral component of membrane|kinase binding|endoplasmic reticulum unfolded protein response|NAD biosynthesis via nicotinamide riboside salvage pathway|IRE1-mediated unfolded protein response|protein serine/threonine kinase activator activity|negative regulation of cell death|protein auto-ADP-ribosylation|endoplasmic reticulum tubular network|positive regulation of protein serine/threonine kinase activity|protein mono-ADP-ribosylation|protein ADP-ribosylase activity|cellular response to leukemia inhibitory factor PARP2 1252.532938 1126.768235 1378.297641 1.223230828 0.290696671 0.228520047 1 24.83831053 29.87456901 10038 poly(ADP-ribose) polymerase 2 "GO:0003677,GO:0003950,GO:0005515,GO:0005654,GO:0005730,GO:0006281,GO:0006284,GO:0006302,GO:0006471,GO:0018312,GO:0030592,GO:0061051,GO:0070212,GO:0097191,GO:0140294,GO:1901215,GO:1990404" DNA binding|NAD+ ADP-ribosyltransferase activity|protein binding|nucleoplasm|nucleolus|DNA repair|base-excision repair|double-strand break repair|protein ADP-ribosylation|peptidyl-serine ADP-ribosylation|DNA ADP-ribosylation|positive regulation of cell growth involved in cardiac muscle cell development|protein poly-ADP-ribosylation|extrinsic apoptotic signaling pathway|NAD DNA ADP-ribosyltransferase activity|negative regulation of neuron death|protein ADP-ribosylase activity "hsa03410,hsa04210" Base excision repair|Apoptosis PARP3 1139.388907 1146.536099 1132.241716 0.987532549 -0.018099795 0.944514975 1 24.16608386 23.46544938 10039 poly(ADP-ribose) polymerase family member 3 "GO:0000723,GO:0003824,GO:0003950,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005814,GO:0006281,GO:0006302,GO:0006471,GO:0016604,GO:0030592,GO:0035861,GO:0045171,GO:0045829,GO:0051106,GO:0060236,GO:0070212,GO:0070213,GO:0140289,GO:0140294,GO:1905662,GO:1990166,GO:1990404,GO:2001034" telomere maintenance|catalytic activity|NAD+ ADP-ribosyltransferase activity|protein binding|nucleoplasm|nucleolus|cytoplasm|centriole|DNA repair|double-strand break repair|protein ADP-ribosylation|nuclear body|DNA ADP-ribosylation|site of double-strand break|intercellular bridge|negative regulation of isotype switching|positive regulation of DNA ligation|regulation of mitotic spindle organization|protein poly-ADP-ribosylation|protein auto-ADP-ribosylation|protein mono-ADP-ribosylation|NAD DNA ADP-ribosyltransferase activity|negative regulation of telomerase RNA reverse transcriptase activity|protein localization to site of double-strand break|protein ADP-ribosylase activity|positive regulation of double-strand break repair via nonhomologous end joining "hsa03410,hsa04210" Base excision repair|Apoptosis PARP4 3160.339767 3332.445666 2988.233867 0.896708954 -0.157288291 0.507071622 1 30.87612855 27.22359814 143 poly(ADP-ribose) polymerase family member 4 "GO:0003677,GO:0003950,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005876,GO:0006281,GO:0006464,GO:0006471,GO:0006954,GO:0006974,GO:0008219,GO:0016020,GO:0019899,GO:0042493,GO:0051972,GO:0070062,GO:0140289,GO:1990404,GO:1990904" DNA binding|NAD+ ADP-ribosyltransferase activity|protein binding|nucleus|cytoplasm|cytosol|spindle microtubule|DNA repair|cellular protein modification process|protein ADP-ribosylation|inflammatory response|cellular response to DNA damage stimulus|cell death|membrane|enzyme binding|response to drug|regulation of telomerase activity|extracellular exosome|protein mono-ADP-ribosylation|protein ADP-ribosylase activity|ribonucleoprotein complex "hsa03410,hsa04210" Base excision repair|Apoptosis PARP6 759.1246222 865.6243504 652.6248941 0.753935462 -0.407487064 0.107537128 1 15.24143208 11.29876887 56965 poly(ADP-ribose) polymerase family member 6 "GO:0003950,GO:0005622,GO:0006471,GO:0050775,GO:0070213,GO:0140289,GO:1990404" NAD+ ADP-ribosyltransferase activity|intracellular anatomical structure|protein ADP-ribosylation|positive regulation of dendrite morphogenesis|protein auto-ADP-ribosylation|protein mono-ADP-ribosylation|protein ADP-ribosylase activity PARP8 973.2535804 986.3123607 960.1948 0.97351999 -0.038717491 0.87920902 1 6.014359909 5.757122439 79668 poly(ADP-ribose) polymerase family member 8 "GO:0003950,GO:0005622,GO:0006471,GO:0070213,GO:0140289,GO:1990404" NAD+ ADP-ribosyltransferase activity|intracellular anatomical structure|protein ADP-ribosylation|protein auto-ADP-ribosylation|protein mono-ADP-ribosylation|protein ADP-ribosylase activity PARP9 577.7648997 621.1270879 534.4027115 0.860375794 -0.216961158 0.414391826 1 4.058823448 3.433677658 83666 poly(ADP-ribose) polymerase family member 9 "GO:0000122,GO:0002230,GO:0003714,GO:0003950,GO:0004857,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006302,GO:0006471,GO:0010608,GO:0010629,GO:0016020,GO:0016477,GO:0019899,GO:0032991,GO:0034356,GO:0035563,GO:0042393,GO:0042531,GO:0043086,GO:0044389,GO:0045087,GO:0045893,GO:0051607,GO:0060330,GO:0060335,GO:0070212,GO:0070403,GO:0072570,GO:0090734,GO:0097677,GO:0140289,GO:1900182,GO:1990404,GO:2001034" "negative regulation of transcription by RNA polymerase II|positive regulation of defense response to virus by host|transcription corepressor activity|NAD+ ADP-ribosyltransferase activity|enzyme inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|double-strand break repair|protein ADP-ribosylation|posttranscriptional regulation of gene expression|negative regulation of gene expression|membrane|cell migration|enzyme binding|protein-containing complex|NAD biosynthesis via nicotinamide riboside salvage pathway|positive regulation of chromatin binding|histone binding|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of catalytic activity|ubiquitin-like protein ligase binding|innate immune response|positive regulation of transcription, DNA-templated|defense response to virus|regulation of response to interferon-gamma|positive regulation of interferon-gamma-mediated signaling pathway|protein poly-ADP-ribosylation|NAD+ binding|ADP-D-ribose binding|site of DNA damage|STAT family protein binding|protein mono-ADP-ribosylation|positive regulation of protein localization to nucleus|protein ADP-ribosylase activity|positive regulation of double-strand break repair via nonhomologous end joining" PARPBP 706.4201749 768.8658593 643.9744905 0.837564164 -0.255728379 0.318206537 1 10.38546135 8.552932797 55010 PARP1 binding protein "GO:0000785,GO:0003677,GO:0005515,GO:0005654,GO:0005737,GO:0006281,GO:2000042" chromatin|DNA binding|protein binding|nucleoplasm|cytoplasm|DNA repair|negative regulation of double-strand break repair via homologous recombination PARS2 135.4229958 148.7791852 122.0668064 0.82045621 -0.28550176 0.504460866 1 3.370149266 2.718790361 25973 "prolyl-tRNA synthetase 2, mitochondrial" "GO:0004827,GO:0005524,GO:0005739,GO:0005759,GO:0006433" proline-tRNA ligase activity|ATP binding|mitochondrion|mitochondrial matrix|prolyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis PARVA 2195.237119 2194.232878 2196.241359 1.000915345 0.00131996 0.997767324 1 13.12657504 12.91873387 55742 parvin alpha "GO:0002040,GO:0003148,GO:0003779,GO:0004860,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0006469,GO:0007163,GO:0008360,GO:0015629,GO:0030018,GO:0030027,GO:0030031,GO:0031532,GO:0034113,GO:0034446,GO:0045296,GO:0050821,GO:0060271,GO:0070252,GO:0071670" sprouting angiogenesis|outflow tract septum morphogenesis|actin binding|protein kinase inhibitor activity|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|focal adhesion|negative regulation of protein kinase activity|establishment or maintenance of cell polarity|regulation of cell shape|actin cytoskeleton|Z disc|lamellipodium|cell projection assembly|actin cytoskeleton reorganization|heterotypic cell-cell adhesion|substrate adhesion-dependent cell spreading|cadherin binding|protein stabilization|cilium assembly|actin-mediated cell contraction|smooth muscle cell chemotaxis hsa04510 Focal adhesion PARVB 1083.246187 1035.211813 1131.28056 1.092801054 0.12803078 0.601951708 1 20.62237844 22.15904482 29780 parvin beta "GO:0003779,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0007163,GO:0015629,GO:0030018,GO:0030027,GO:0030031,GO:0030032,GO:0031532,GO:0034446,GO:0071963" actin binding|protein binding|cytoplasm|cytosol|plasma membrane|focal adhesion|establishment or maintenance of cell polarity|actin cytoskeleton|Z disc|lamellipodium|cell projection assembly|lamellipodium assembly|actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading|establishment or maintenance of cell polarity regulating cell shape hsa04510 Focal adhesion PARVG 68.13766286 60.34400519 75.93132052 1.258307603 0.331484643 0.549231154 1 0.543352227 0.672263374 64098 parvin gamma "GO:0003779,GO:0005515,GO:0005737,GO:0005856,GO:0005886,GO:0005925,GO:0007160,GO:0007163,GO:0015629,GO:0030031,GO:0031532,GO:0034446" actin binding|protein binding|cytoplasm|cytoskeleton|plasma membrane|focal adhesion|cell-matrix adhesion|establishment or maintenance of cell polarity|actin cytoskeleton|cell projection assembly|actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading hsa04510 Focal adhesion PASK 570.9128907 630.4908129 511.3349686 0.811010975 -0.302206658 0.255437786 1 4.594856738 3.664121657 23178 PAS domain containing serine/threonine kinase "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0035091,GO:0035556,GO:0043576,GO:0045719,GO:0045727,GO:0046777,GO:0070092,GO:0097009,GO:0106310,GO:0106311" protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|protein phosphorylation|phosphatidylinositol binding|intracellular signal transduction|regulation of respiratory gaseous exchange|negative regulation of glycogen biosynthetic process|positive regulation of translation|protein autophosphorylation|regulation of glucagon secretion|energy homeostasis|protein serine kinase activity|protein threonine kinase activity PATJ 937.8996301 865.6243504 1010.17491 1.166989941 0.222792126 0.36849889 1 4.907242472 5.630873991 10207 PATJ crumbs cell polarity complex component "GO:0005515,GO:0005829,GO:0005886,GO:0005923,GO:0016324,GO:0030054,GO:0034451,GO:0035089,GO:0035556,GO:0048471,GO:0070062,GO:0070830,GO:0120192" protein binding|cytosol|plasma membrane|bicellular tight junction|apical plasma membrane|cell junction|centriolar satellite|establishment of apical/basal cell polarity|intracellular signal transduction|perinuclear region of cytoplasm|extracellular exosome|bicellular tight junction assembly|tight junction assembly "hsa04390,hsa04530,hsa05165" Hippo signaling pathway|Tight junction|Human papillomavirus infection PATL1 2914.052327 3111.877923 2716.226732 0.87285774 -0.196181555 0.407294777 1 40.22165303 34.5203 219988 "PAT1 homolog 1, processing body mRNA decay factor" "GO:0000290,GO:0000932,GO:0003723,GO:0005515,GO:0005829,GO:0008266,GO:0016605,GO:0016607,GO:0030014,GO:0033962,GO:0034046,GO:0036464,GO:0043928" deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|RNA binding|protein binding|cytosol|poly(U) RNA binding|PML body|nuclear speck|CCR4-NOT complex|P-body assembly|poly(G) binding|cytoplasmic ribonucleoprotein granule|exonucleolytic catabolism of deadenylated mRNA hsa03018 RNA degradation PATL2 12.049048 13.52538047 10.57271552 0.781694499 -0.355323209 0.80166462 1 0.262100471 0.201454065 197135 PAT1 homolog 2 "GO:0000290,GO:0000932,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0010607,GO:0017148,GO:0033962,GO:1990904" deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|RNA binding|protein binding|nucleus|cytoplasm|negative regulation of cytoplasmic mRNA processing body assembly|negative regulation of translation|P-body assembly|ribonucleoprotein complex PATZ1 632.1985446 700.198543 564.1985462 0.80576938 -0.311561111 0.231825525 1 7.626185578 6.042119465 23598 POZ/BTB and AT hook containing zinc finger 1 "GO:0000122,GO:0000978,GO:0001227,GO:0003677,GO:0003682,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0007283,GO:0008584,GO:0010596,GO:0030217,GO:0031625,GO:0045892,GO:0045893,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|chromatin binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|spermatogenesis|male gonad development|negative regulation of endothelial cell migration|T cell differentiation|ubiquitin protein ligase binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding" ZBTB PAWR 2212.135992 2297.233853 2127.038131 0.925912757 -0.111051831 0.639504935 1 11.61636807 10.57576059 5074 pro-apoptotic WT1 regulator "GO:0000122,GO:0000785,GO:0003714,GO:0003779,GO:0005515,GO:0005634,GO:0005737,GO:0005884,GO:0005886,GO:0006915,GO:0010628,GO:0015629,GO:0019899,GO:0030889,GO:0042130,GO:0042986,GO:0043065,GO:0043522,GO:0048147,GO:0050860,GO:0051017,GO:0097190,GO:1901300,GO:2000774" negative regulation of transcription by RNA polymerase II|chromatin|transcription corepressor activity|actin binding|protein binding|nucleus|cytoplasm|actin filament|plasma membrane|apoptotic process|positive regulation of gene expression|actin cytoskeleton|enzyme binding|negative regulation of B cell proliferation|negative regulation of T cell proliferation|positive regulation of amyloid precursor protein biosynthetic process|positive regulation of apoptotic process|leucine zipper domain binding|negative regulation of fibroblast proliferation|negative regulation of T cell receptor signaling pathway|actin filament bundle assembly|apoptotic signaling pathway|positive regulation of hydrogen peroxide-mediated programmed cell death|positive regulation of cellular senescence PAX5 25.65871681 30.1720026 21.14543103 0.700829551 -0.512864486 0.526676168 1 0.184998199 0.127482651 5079 paired box 5 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001650,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0006366,GO:0006959,GO:0007275,GO:0007283,GO:0007568,GO:0009887,GO:0021670,GO:0021987,GO:0030534,GO:0035914,GO:0043231,GO:0045944,GO:0048701,GO:0048856,GO:0050855,GO:0051573" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|fibrillar center|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|humoral immune response|multicellular organism development|spermatogenesis|aging|animal organ morphogenesis|lateral ventricle development|cerebral cortex development|adult behavior|skeletal muscle cell differentiation|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|embryonic cranial skeleton morphogenesis|anatomical structure development|regulation of B cell receptor signaling pathway|negative regulation of histone H3-K9 methylation" hsa05202 Transcriptional misregulation in cancer PAX PAX6 635.2455587 691.875232 578.6158855 0.836300909 -0.257905964 0.322444824 1 6.397108371 5.260384089 5080 paired box 6 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001568,GO:0001654,GO:0003322,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0007417,GO:0007601,GO:0008134,GO:0009611,GO:0009887,GO:0010628,GO:0019901,GO:0021517,GO:0035035,GO:0042593,GO:0045893,GO:0045944,GO:0048663,GO:0048856,GO:0050768,GO:0061072,GO:0061303,GO:0070412,GO:1904798,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|blood vessel development|eye development|pancreatic A cell development|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|central nervous system development|visual perception|transcription factor binding|response to wounding|animal organ morphogenesis|positive regulation of gene expression|protein kinase binding|ventral spinal cord development|histone acetyltransferase binding|glucose homeostasis|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|neuron fate commitment|anatomical structure development|negative regulation of neurogenesis|iris morphogenesis|cornea development in camera-type eye|R-SMAD binding|positive regulation of core promoter binding|sequence-specific double-stranded DNA binding" "hsa04550,hsa04950" Signaling pathways regulating pluripotency of stem cells|Maturity onset diabetes of the young PAX PAX8 7923.869735 8796.699378 7051.040093 0.801555196 -0.319126226 0.195658642 1 115.7740267 91.24640248 7849 paired box 8 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001655,GO:0001658,GO:0001822,GO:0001823,GO:0003337,GO:0003677,GO:0003700,GO:0004996,GO:0005515,GO:0005634,GO:0005654,GO:0006351,GO:0006357,GO:0007417,GO:0009653,GO:0030878,GO:0038194,GO:0039003,GO:0042472,GO:0042981,GO:0045893,GO:0045944,GO:0048793,GO:0048856,GO:0071371,GO:0071599,GO:0072108,GO:0072207,GO:0072221,GO:0072278,GO:0072284,GO:0072289,GO:0072305,GO:0072307,GO:0090190,GO:1900212,GO:1900215,GO:1900218,GO:1990837,GO:2000594,GO:2000611,GO:2000612" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|urogenital system development|branching involved in ureteric bud morphogenesis|kidney development|mesonephros development|mesenchymal to epithelial transition involved in metanephros morphogenesis|DNA binding|DNA-binding transcription factor activity|thyroid-stimulating hormone receptor activity|protein binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription by RNA polymerase II|central nervous system development|anatomical structure morphogenesis|thyroid gland development|thyroid-stimulating hormone signaling pathway|pronephric field specification|inner ear morphogenesis|regulation of apoptotic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|pronephros development|anatomical structure development|cellular response to gonadotropin stimulus|otic vesicle development|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|metanephric epithelium development|metanephric distal convoluted tubule development|metanephric comma-shaped body morphogenesis|metanephric S-shaped body morphogenesis|metanephric nephron tubule formation|negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis|regulation of metanephric nephron tubule epithelial cell differentiation|positive regulation of branching involved in ureteric bud morphogenesis|negative regulation of mesenchymal cell apoptotic process involved in metanephros development|negative regulation of apoptotic process involved in metanephric collecting duct development|negative regulation of apoptotic process involved in metanephric nephron tubule development|sequence-specific double-stranded DNA binding|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|regulation of thyroid-stimulating hormone secretion" "hsa04918,hsa05200,hsa05202,hsa05216" Thyroid hormone synthesis|Pathways in cancer|Transcriptional misregulation in cancer|Thyroid cancer PAX9 342.1495555 352.7003062 331.5988048 0.940171582 -0.089004021 0.776443053 1 4.037530482 3.732450979 5083 paired box 9 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0007492,GO:0042476,GO:0042481,GO:0045892,GO:0045944,GO:0048856,GO:0060325,GO:0071363,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|endoderm development|odontogenesis|regulation of odontogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|anatomical structure development|face morphogenesis|cellular response to growth factor stimulus|sequence-specific double-stranded DNA binding" PAXBP1 914.8664857 879.1497308 950.5832405 1.081252951 0.11270407 0.652108477 1 10.4752412 11.13685373 94104 PAX3 and PAX7 binding protein 1 "GO:0003677,GO:0005634,GO:0005829,GO:0007517,GO:0008134,GO:0014842,GO:0031062,GO:0045944,GO:2000288" DNA binding|nucleus|cytosol|muscle organ development|transcription factor binding|regulation of skeletal muscle satellite cell proliferation|positive regulation of histone methylation|positive regulation of transcription by RNA polymerase II|positive regulation of myoblast proliferation PAXIP1 542.6386623 531.651494 553.6258307 1.04133222 0.058430411 0.833953926 1 5.188016658 5.312046239 22976 PAX interacting protein 1 "GO:0000416,GO:0001570,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006303,GO:0006310,GO:0010212,GO:0016363,GO:0030330,GO:0031398,GO:0035066,GO:0035097,GO:0043433,GO:0043542,GO:0044666,GO:0045830,GO:0048304,GO:0051568,GO:0051571,GO:0060261,GO:0060612,GO:0060717,GO:1902749,GO:2001022" "positive regulation of histone H3-K36 methylation|vasculogenesis|protein binding|nucleus|nucleoplasm|chromosome|double-strand break repair via nonhomologous end joining|DNA recombination|response to ionizing radiation|nuclear matrix|DNA damage response, signal transduction by p53 class mediator|positive regulation of protein ubiquitination|positive regulation of histone acetylation|histone methyltransferase complex|negative regulation of DNA-binding transcription factor activity|endothelial cell migration|MLL3/4 complex|positive regulation of isotype switching|positive regulation of isotype switching to IgG isotypes|histone H3-K4 methylation|positive regulation of histone H3-K4 methylation|positive regulation of transcription initiation from RNA polymerase II promoter|adipose tissue development|chorion development|regulation of cell cycle G2/M phase transition|positive regulation of response to DNA damage stimulus" PAXX 531.2488298 472.3479027 590.149757 1.249396374 0.321231248 0.233949251 1 31.19843989 38.32695325 286257 PAXX non-homologous end joining factor "GO:0005515,GO:0005634,GO:0005654,GO:0006303,GO:0006974,GO:0035861,GO:0042803,GO:0043564,GO:0051103,GO:0060090,GO:0070419" protein binding|nucleus|nucleoplasm|double-strand break repair via nonhomologous end joining|cellular response to DNA damage stimulus|site of double-strand break|protein homodimerization activity|Ku70:Ku80 complex|DNA ligation involved in DNA repair|molecular adaptor activity|nonhomologous end joining complex PBDC1 380.7838777 382.8723088 378.6954467 0.989090718 -0.015825247 0.966866392 1 17.24319952 16.76969478 51260 polysaccharide biosynthesis domain containing 1 "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process PBK 1072.386622 951.9787026 1192.794541 1.252963473 0.325344357 0.183108185 1 27.67176127 34.09152206 55872 PDZ binding kinase "GO:0000165,GO:0000187,GO:0000278,GO:0001933,GO:0004674,GO:0004708,GO:0005515,GO:0005524,GO:0005634,GO:0006468,GO:0032435,GO:0032873,GO:0034644,GO:0050728" MAPK cascade|activation of MAPK activity|mitotic cell cycle|negative regulation of protein phosphorylation|protein serine/threonine kinase activity|MAP kinase kinase activity|protein binding|ATP binding|nucleus|protein phosphorylation|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of stress-activated MAPK cascade|cellular response to UV|negative regulation of inflammatory response PBLD 43.07338049 45.77821084 40.36855015 0.881828918 -0.181429306 0.805840511 1 0.82929361 0.719057854 64081 phenazine biosynthesis like protein domain containing "GO:0003674,GO:0005515,GO:0005737,GO:0009058,GO:0010633,GO:0010719,GO:0016853,GO:0030277,GO:0030512,GO:0042802,GO:0050680,GO:0060392,GO:0060394,GO:0070062" molecular_function|protein binding|cytoplasm|biosynthetic process|negative regulation of epithelial cell migration|negative regulation of epithelial to mesenchymal transition|isomerase activity|maintenance of gastrointestinal epithelium|negative regulation of transforming growth factor beta receptor signaling pathway|identical protein binding|negative regulation of epithelial cell proliferation|negative regulation of SMAD protein signal transduction|negative regulation of pathway-restricted SMAD protein phosphorylation|extracellular exosome PBRM1 1051.071386 1174.627274 927.5154975 0.789625372 -0.340759749 0.163769709 1 7.025406109 5.454610033 55193 polybromo 1 "GO:0000228,GO:0000278,GO:0003677,GO:0003682,GO:0005515,GO:0005654,GO:0006338,GO:0008285,GO:0016586,GO:0043044" nuclear chromosome|mitotic cell cycle|DNA binding|chromatin binding|protein binding|nucleoplasm|chromatin remodeling|negative regulation of cell population proliferation|RSC-type complex|ATP-dependent chromatin remodeling hsa05225 Hepatocellular carcinoma PBX1 10.04747816 11.44455271 8.650403604 0.755853359 -0.403821727 0.795727704 1 0.069762963 0.051848195 5087 PBX homeobox 1 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001654,GO:0001658,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006694,GO:0007221,GO:0007420,GO:0007548,GO:0008284,GO:0009887,GO:0009952,GO:0009954,GO:0010971,GO:0030278,GO:0030325,GO:0030326,GO:0035019,GO:0035162,GO:0045665,GO:0048536,GO:0048538,GO:0048568,GO:0048666,GO:0048706,GO:0090575,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|eye development|branching involved in ureteric bud morphogenesis|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|steroid biosynthetic process|positive regulation of transcription of Notch receptor target|brain development|sex differentiation|positive regulation of cell population proliferation|animal organ morphogenesis|anterior/posterior pattern specification|proximal/distal pattern formation|positive regulation of G2/M transition of mitotic cell cycle|regulation of ossification|adrenal gland development|embryonic limb morphogenesis|somatic stem cell population maintenance|embryonic hemopoiesis|negative regulation of neuron differentiation|spleen development|thymus development|embryonic organ development|neuron development|embryonic skeletal system development|RNA polymerase II transcription regulator complex|sequence-specific double-stranded DNA binding" "hsa04927,hsa04934,hsa05202" Cortisol synthesis and secretion|Cushing syndrome|Transcriptional misregulation in cancer Homeobox PBX2 914.25696 900.9984224 927.5154975 1.029430768 0.041846808 0.870227608 1 14.89149267 15.07323795 5089 PBX homeobox 2 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001654,GO:0003682,GO:0005515,GO:0005634,GO:0005667,GO:0006357,GO:0007420,GO:0008134,GO:0009887,GO:0009954,GO:0030326,GO:0045944,GO:0048568,GO:0048666" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|eye development|chromatin binding|protein binding|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|brain development|transcription factor binding|animal organ morphogenesis|proximal/distal pattern formation|embryonic limb morphogenesis|positive regulation of transcription by RNA polymerase II|embryonic organ development|neuron development" Homeobox PBX3 1294.006683 1067.464644 1520.548722 1.424448792 0.510403759 0.034139286 0.939345539 19.80139941 27.73408894 5090 PBX homeobox 3 "GO:0000785,GO:0000978,GO:0000981,GO:0001654,GO:0005634,GO:0006357,GO:0007387,GO:0007388,GO:0007420,GO:0009887,GO:0048568,GO:0048666" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|eye development|nucleus|regulation of transcription by RNA polymerase II|anterior compartment pattern formation|posterior compartment specification|brain development|animal organ morphogenesis|embryonic organ development|neuron development" hsa05202 Transcriptional misregulation in cancer Homeobox PBX4 54.80539678 50.98028025 58.63051332 1.150062593 0.201712384 0.752681287 1 1.547624493 1.750081407 80714 PBX homeobox 4 "GO:0000785,GO:0000978,GO:0000981,GO:0001654,GO:0001741,GO:0005515,GO:0005634,GO:0006357,GO:0007420,GO:0009887,GO:0043565,GO:0045893,GO:0048568,GO:0048666" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|eye development|XY body|protein binding|nucleus|regulation of transcription by RNA polymerase II|brain development|animal organ morphogenesis|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|embryonic organ development|neuron development" PBXIP1 1293.063806 1320.285217 1265.842394 0.958764347 -0.060751833 0.803470028 1 21.97106188 20.71257537 57326 PBX homeobox interacting protein 1 "GO:0003714,GO:0005515,GO:0005634,GO:0005829,GO:0005874,GO:0007275,GO:0016020,GO:0030154,GO:0045892,GO:2001106" "transcription corepressor activity|protein binding|nucleus|cytosol|microtubule|multicellular organism development|membrane|cell differentiation|negative regulation of transcription, DNA-templated|regulation of Rho guanyl-nucleotide exchange factor activity" PC 100.2319774 120.6880104 79.77594435 0.66100969 -0.597256674 0.201986993 1 1.016716227 0.660813276 5091 pyruvate carboxylase "GO:0004736,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006090,GO:0006094,GO:0006629,GO:0006768,GO:0009374,GO:0010629,GO:0019074,GO:0042802,GO:0044791,GO:0044794,GO:0046872" pyruvate carboxylase activity|protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|pyruvate metabolic process|gluconeogenesis|lipid metabolic process|biotin metabolic process|biotin binding|negative regulation of gene expression|viral RNA genome packaging|identical protein binding|positive regulation by host of viral release from host cell|positive regulation by host of viral process|metal ion binding "hsa00020,hsa00620" Citrate cycle (TCA cycle)|Pyruvate metabolism PCBD1 1185.375938 1117.40451 1253.347367 1.121659484 0.165634766 0.495560945 1 58.3501223 64.35376826 5092 pterin-4 alpha-carbinolamine dehydratase 1 "GO:0003713,GO:0004505,GO:0005515,GO:0005654,GO:0005829,GO:0006559,GO:0006729,GO:0008124,GO:0042802,GO:0043393,GO:0045893,GO:0055114,GO:0070062" "transcription coactivator activity|phenylalanine 4-monooxygenase activity|protein binding|nucleoplasm|cytosol|L-phenylalanine catabolic process|tetrahydrobiopterin biosynthetic process|4-alpha-hydroxytetrahydrobiopterin dehydratase activity|identical protein binding|regulation of protein binding|positive regulation of transcription, DNA-templated|oxidation-reduction process|extracellular exosome" hsa00790 Folate biosynthesis PCBD2 117.2899804 126.9304937 107.6494671 0.848097758 -0.237697525 0.601558061 1 2.864290554 2.388549051 84105 pterin-4 alpha-carbinolamine dehydratase 2 "GO:0004505,GO:0005515,GO:0005575,GO:0005634,GO:0006729,GO:0008124,GO:0042802,GO:0045893,GO:0055114" "phenylalanine 4-monooxygenase activity|protein binding|cellular_component|nucleus|tetrahydrobiopterin biosynthetic process|4-alpha-hydroxytetrahydrobiopterin dehydratase activity|identical protein binding|positive regulation of transcription, DNA-templated|oxidation-reduction process" hsa00790 Folate biosynthesis PCBP1 3275.580331 3178.464411 3372.69625 1.061108703 0.085572458 0.718911394 1 98.22165829 102.4798114 5093 poly(rC) binding protein 1 "GO:0000398,GO:0000981,GO:0003697,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0010468,GO:0016020,GO:0016070,GO:0016607,GO:0036464,GO:0039694,GO:0045296,GO:0045944,GO:0051252,GO:0070062,GO:0098847" "mRNA splicing, via spliceosome|DNA-binding transcription factor activity, RNA polymerase II-specific|single-stranded DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of gene expression|membrane|RNA metabolic process|nuclear speck|cytoplasmic ribonucleoprotein granule|viral RNA genome replication|cadherin binding|positive regulation of transcription by RNA polymerase II|regulation of RNA metabolic process|extracellular exosome|sequence-specific single stranded DNA binding" "hsa03040,hsa04216" Spliceosome|Ferroptosis PCBP2 9484.003261 8952.76146 10015.24506 1.118676635 0.16179307 0.517784945 1 150.6756306 165.7367291 5094 poly(rC) binding protein 2 "GO:0000398,GO:0003697,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005925,GO:0010468,GO:0014069,GO:0016020,GO:0016070,GO:0016071,GO:0019899,GO:0031625,GO:0032480,GO:0039694,GO:0043161,GO:0045087,GO:0045944,GO:0050687,GO:0051252,GO:0051607,GO:0070062,GO:0075522,GO:1990829" "mRNA splicing, via spliceosome|single-stranded DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|focal adhesion|regulation of gene expression|postsynaptic density|membrane|RNA metabolic process|mRNA metabolic process|enzyme binding|ubiquitin protein ligase binding|negative regulation of type I interferon production|viral RNA genome replication|proteasome-mediated ubiquitin-dependent protein catabolic process|innate immune response|positive regulation of transcription by RNA polymerase II|negative regulation of defense response to virus|regulation of RNA metabolic process|defense response to virus|extracellular exosome|IRES-dependent viral translational initiation|C-rich single-stranded DNA binding" hsa04216 Ferroptosis PCBP4 1108.300408 1074.747541 1141.853276 1.062438603 0.087379472 0.722557937 1 23.55535973 24.6073452 57060 poly(rC) binding protein 4 "GO:0003677,GO:0003723,GO:0003729,GO:0003730,GO:0005634,GO:0005737,GO:0005829,GO:0006977,GO:0010468,GO:0043488,GO:0048025,GO:0051252" "DNA binding|RNA binding|mRNA binding|mRNA 3'-UTR binding|nucleus|cytoplasm|cytosol|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|regulation of gene expression|regulation of mRNA stability|negative regulation of mRNA splicing, via spliceosome|regulation of RNA metabolic process" PCCA 336.3234835 300.6796121 371.967355 1.237088715 0.306948964 0.314023098 1 3.07408396 3.739277951 5095 propionyl-CoA carboxylase subunit alpha "GO:0004658,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0005829,GO:0006768,GO:0009374,GO:0016421,GO:0019626,GO:0019899,GO:0046872" propionyl-CoA carboxylase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|cytosol|biotin metabolic process|biotin binding|CoA carboxylase activity|short-chain fatty acid catabolic process|enzyme binding|metal ion binding "hsa00280,hsa00630,hsa00640" "Valine, leucine and isoleucine degradation|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism" PCCB 629.9145416 703.3197847 556.5092985 0.791260691 -0.337775008 0.195004111 1 19.26842108 14.99121725 5096 propionyl-CoA carboxylase subunit beta "GO:0004658,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0005829,GO:0006768,GO:0019626" propionyl-CoA carboxylase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|cytosol|biotin metabolic process|short-chain fatty acid catabolic process "hsa00280,hsa00630,hsa00640" "Valine, leucine and isoleucine degradation|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism" PCDH1 761.6268917 817.7653118 705.4884717 0.862702858 -0.213064359 0.401207621 1 4.619734487 3.918766901 5097 protocadherin 1 "GO:0005509,GO:0005654,GO:0005730,GO:0005886,GO:0005887,GO:0005911,GO:0007155,GO:0007156,GO:0007267,GO:0007399,GO:0030054,GO:0043231" calcium ion binding|nucleoplasm|nucleolus|plasma membrane|integral component of plasma membrane|cell-cell junction|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development|cell junction|intracellular membrane-bounded organelle PCDH12 8.006279355 8.323311061 7.689247648 0.923820772 -0.11431511 1 1 0.075853793 0.068902694 51294 protocadherin 12 "GO:0005509,GO:0005886,GO:0005887,GO:0005911,GO:0005977,GO:0007155,GO:0007156,GO:0008038,GO:0016339,GO:0060711,GO:0070062" calcium ion binding|plasma membrane|integral component of plasma membrane|cell-cell junction|glycogen metabolic process|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|neuron recognition|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|labyrinthine layer development|extracellular exosome PCDH15 65.46240064 40.57614142 90.34865986 2.226644937 1.154871523 0.034877655 0.95006405 0.12942885 0.28336959 65217 protocadherin related 15 "GO:0001750,GO:0005509,GO:0005576,GO:0005887,GO:0007155,GO:0007156,GO:0007605,GO:0032420,GO:0045202,GO:0045494,GO:0048839,GO:0050953,GO:0050957" photoreceptor outer segment|calcium ion binding|extracellular region|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|sensory perception of sound|stereocilium|synapse|photoreceptor cell maintenance|inner ear development|sensory perception of light stimulus|equilibrioception PCDH17 32.78812856 28.09117483 37.48508228 1.334407781 0.416199607 0.575229901 1 0.125233846 0.164316609 27253 protocadherin 17 "GO:0005509,GO:0005515,GO:0005887,GO:0007155,GO:0007156,GO:0030534,GO:0050805,GO:0098978,GO:0098982,GO:0099055,GO:0099056,GO:0099560,GO:1904071,GO:2000807" calcium ion binding|protein binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|adult behavior|negative regulation of synaptic transmission|glutamatergic synapse|GABA-ergic synapse|integral component of postsynaptic membrane|integral component of presynaptic membrane|synaptic membrane adhesion|presynaptic active zone assembly|regulation of synaptic vesicle clustering PCDH18 113.1975219 145.6579436 80.7371003 0.554292463 -0.851280704 0.057383672 1 1.302966266 0.710138934 54510 protocadherin 18 "GO:0005509,GO:0005515,GO:0005887,GO:0007155,GO:0007156,GO:0007420" calcium ion binding|protein binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|brain development PCDH19 23.37974423 20.80827765 25.95121081 1.247158042 0.318644297 0.730254613 1 0.127321662 0.156133095 57526 protocadherin 19 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007420" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|brain development PCDH7 294.9541485 299.6391982 290.2690987 0.968728726 -0.045835372 0.895564276 1 1.137515528 1.083504428 5099 protocadherin 7 "GO:0002576,GO:0005509,GO:0005886,GO:0005887,GO:0007155,GO:0007156,GO:0031092" platelet degranulation|calcium ion binding|plasma membrane|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|platelet alpha granule membrane PCDHB10 26.62490319 17.687036 35.56277037 2.010668738 1.007675414 0.189583361 1 0.286471807 0.566361328 56126 protocadherin beta 10 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHB11 29.46371167 29.13158871 29.79583464 1.022801569 0.032526278 1 1 0.37435573 0.376484455 56125 protocadherin beta 11 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007399,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|nervous system development|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHB12 28.90387577 27.05076095 30.75699059 1.137010181 0.185245172 0.844935022 1 0.374681909 0.418888325 56124 protocadherin beta 12 "GO:0005509,GO:0005515,GO:0005887,GO:0007155,GO:0007156,GO:0007399" calcium ion binding|protein binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|nervous system development PCDHB13 25.01962298 26.01034707 24.0288989 0.923820772 -0.11431511 0.937424536 1 0.274278684 0.249144301 56123 protocadherin beta 13 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHB14 35.98862813 36.41448589 35.56277037 0.97661053 -0.034144761 1 1 0.439976044 0.422495037 56122 protocadherin beta 14 "GO:0005509,GO:0005515,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|protein binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHB15 10.40916924 8.323311061 12.49502743 1.501208754 0.586124608 0.656643747 1 0.111860945 0.165116606 56121 protocadherin beta 15 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007399,GO:0032391" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|nervous system development|photoreceptor connecting cilium PCDHB16 14.93251586 13.52538047 16.33965125 1.208073317 0.272708013 0.840283495 1 0.187975182 0.223287794 57717 protocadherin beta 16 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHB2 76.81763459 86.35435226 67.28091692 0.779125952 -0.360071524 0.492402334 1 1.127066047 0.863432151 56133 protocadherin beta 2 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007399,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|nervous system development|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHB3 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.049649756 0.075166576 56132 protocadherin beta 3 "GO:0005509,GO:0005515,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007399,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|protein binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|nervous system development|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHB4 5.003924597 5.202069413 4.80577978 0.923820772 -0.11431511 1 1 0.072944005 0.066259554 56131 protocadherin beta 4 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007399,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|nervous system development|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHB5 3.522561699 4.161655531 2.883467868 0.692865579 -0.529352609 0.940314863 1 0.065131937 0.044372527 26167 protocadherin beta 5 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHB6 20.4566474 19.76786377 21.14543103 1.069687209 0.097188995 0.973111657 1 0.348636668 0.36669167 56130 protocadherin beta 6 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007399,GO:0007416,GO:0009988,GO:0016021,GO:0016339,GO:0042802,GO:0045202" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|nervous system development|synapse assembly|cell-cell recognition|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|identical protein binding|synapse PCDHB7 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.01484625 0.040457304 56129 protocadherin beta 7 "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHB8 18.9752845 18.72744989 19.22311912 1.026467524 0.037687984 1 1 0.363436211 0.36681289 56128 protocadherin beta 8 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0042802" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|identical protein binding PCDHB9 53.44292078 53.06110801 53.82473354 1.014391436 0.02061447 1 1 0.646376127 0.644706517 56127 protocadherin beta 9 "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416,GO:0016021,GO:0016339,GO:0045202" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse PCDHGA1 19.37660456 16.64662212 22.10658699 1.327992359 0.409246846 0.674434087 1 0.140948695 0.184046607 56114 "protocadherin gamma subfamily A, 1" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGA10 321.8860225 350.6194785 293.1525666 0.836098918 -0.258254459 0.404081479 1 2.817211255 2.316051727 56106 "protocadherin gamma subfamily A, 10" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGA11 44.71325924 50.98028025 38.44623824 0.754139406 -0.407096859 0.529436964 1 0.468605556 0.347480347 56105 "protocadherin gamma subfamily A, 11" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGA12 20.33776051 16.64662212 24.0288989 1.443469956 0.52954108 0.559397576 1 0.181565426 0.257698612 26025 "protocadherin gamma subfamily A, 12" "GO:0005509,GO:0005887,GO:0005911,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell-cell junction|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGA2 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.008256502 0.022499675 56113 "protocadherin gamma subfamily A, 2" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGA4 23.61751801 27.05076095 20.18427508 0.746162931 -0.422437405 0.625642426 1 0.295224825 0.216599636 56111 "protocadherin gamma subfamily A, 4" "GO:0005509,GO:0005515,GO:0005887,GO:0007155,GO:0007156,GO:0007283" calcium ion binding|protein binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|spermatogenesis PCDHGA5 18.93565554 17.687036 20.18427508 1.141190365 0.190539472 0.886696091 1 0.162773686 0.182647391 56110 "protocadherin gamma subfamily A, 5" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGA6 39.71436507 33.29324424 46.13548589 1.385731158 0.470647391 0.485584924 1 0.22400394 0.305214961 56109 "protocadherin gamma subfamily A, 6" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGA7 5.444873611 4.161655531 6.728091692 1.616686351 0.693039812 0.747994079 1 0.040857231 0.064948014 56108 "protocadherin gamma subfamily A, 7" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGA8 17.41466368 15.60620824 19.22311912 1.231761029 0.300722389 0.792076496 1 0.131617359 0.159408257 9708 "protocadherin gamma subfamily A, 8" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGA9 32.82775752 29.13158871 36.52392633 1.253756762 0.326257481 0.670235681 1 0.317350347 0.391222158 56107 "protocadherin gamma subfamily A, 9" "GO:0003723,GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007283" RNA binding|calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|spermatogenesis PCDHGB1 33.98705829 34.33365813 33.64045846 0.979809909 -0.029426212 1 1 0.383974064 0.369926034 56104 "protocadherin gamma subfamily B, 1" "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0030426" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|growth cone PCDHGB2 36.18677295 41.61655531 30.75699059 0.739056617 -0.436243205 0.53600437 1 0.467087081 0.33942728 56103 "protocadherin gamma subfamily B, 2" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGB3 17.21148845 22.88910542 11.53387147 0.503902239 -0.988784228 0.282662815 1 0.255821882 0.126752098 56102 "protocadherin gamma subfamily B, 3" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGB4 2.923096831 1.040413883 4.80577978 4.619103859 2.207612985 0.416510993 1 0.011625833 0.052802316 8641 "protocadherin gamma subfamily B, 4" "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0016020,GO:0016339" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules PCDHGB5 168.4042388 194.5573961 142.2510815 0.731152269 -0.451756204 0.245482603 1 2.156421733 1.550289161 56101 "protocadherin gamma subfamily B, 5" "GO:0003674,GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0008150,GO:0070062" molecular_function|calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|biological_process|extracellular exosome PCDHGB6 32.86738648 30.1720026 35.56277037 1.178667881 0.237157261 0.770361225 1 0.292502148 0.338993747 56100 "protocadherin gamma subfamily B, 6" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGB7 41.19572796 34.33365813 48.0577978 1.399728442 0.485146961 0.464436721 1 0.371141226 0.510803852 56099 "protocadherin gamma subfamily B, 7" "GO:0005509,GO:0005887,GO:0007155,GO:0007156" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules PCDHGC3 1140.978482 1276.587834 1005.36913 0.787544032 -0.344567507 0.156285398 1 13.60677979 10.53662151 5098 "protocadherin gamma subfamily C, 3" "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0016020,GO:0016339,GO:0050808" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse organization PCDHGC4 9.20520909 14.56579436 3.844623824 0.263948792 -1.921670032 0.12045037 1 0.157453853 0.040864308 56098 "protocadherin gamma subfamily C, 4" "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0050808" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|synapse organization PCDHGC5 20.13458528 23.9295193 16.33965125 0.682824049 -0.550414225 0.541935781 1 0.256749993 0.172381409 56097 "protocadherin gamma subfamily C, 5" "GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0050808" calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|synapse organization PCED1A 494.3531516 500.4390776 488.2672256 0.975677655 -0.035523507 0.904372824 1 11.3215404 10.86133122 64773 PC-esterase domain containing 1A GO:0005515 protein binding PCED1B 148.5174881 151.9004269 145.1345494 0.955458469 -0.065734929 0.888142279 1 1.598944103 1.502160281 91523 PC-esterase domain containing 1B GO:0005515 protein binding PCF11 640.0513385 691.875232 588.2274451 0.850192951 -0.234137798 0.368775094 1 4.90099675 4.097067253 51585 PCF11 cleavage and polyadenylation factor subunit "GO:0000398,GO:0000993,GO:0003729,GO:0005654,GO:0005737,GO:0005739,GO:0005849,GO:0006369,GO:0006378,GO:0006379,GO:0031124" "mRNA splicing, via spliceosome|RNA polymerase II complex binding|mRNA binding|nucleoplasm|cytoplasm|mitochondrion|mRNA cleavage factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA cleavage|mRNA 3'-end processing" hsa03015 mRNA surveillance pathway PCGF1 314.1030401 285.0734038 343.1326763 1.20366429 0.267433071 0.391262247 1 14.35268266 16.98672428 84759 polycomb group ring finger 1 "GO:0000122,GO:0005515,GO:0005634,GO:0005654,GO:0006342,GO:0006355,GO:0008022,GO:0031519,GO:0035102,GO:0035518,GO:0036353,GO:0046872,GO:1990841" "negative regulation of transcription by RNA polymerase II|protein binding|nucleus|nucleoplasm|chromatin silencing|regulation of transcription, DNA-templated|protein C-terminus binding|PcG protein complex|PRC1 complex|histone H2A monoubiquitination|histone H2A-K119 monoubiquitination|metal ion binding|promoter-specific chromatin binding" hsa04550 Signaling pathways regulating pluripotency of stem cells other PCGF2 1316.285034 1336.931839 1295.638229 0.969113152 -0.045262973 0.853600593 1 17.18439188 16.3749444 7703 polycomb group ring finger 2 "GO:0000122,GO:0000785,GO:0001701,GO:0001739,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006342,GO:0009952,GO:0016573,GO:0016604,GO:0031519,GO:0035102,GO:0036353,GO:0046872,GO:0048704,GO:0070301,GO:0070317,GO:1990841,GO:2001234" negative regulation of transcription by RNA polymerase II|chromatin|in utero embryonic development|sex chromatin|DNA binding|protein binding|nucleus|nucleoplasm|chromatin silencing|anterior/posterior pattern specification|histone acetylation|nuclear body|PcG protein complex|PRC1 complex|histone H2A-K119 monoubiquitination|metal ion binding|embryonic skeletal system morphogenesis|cellular response to hydrogen peroxide|negative regulation of G0 to G1 transition|promoter-specific chromatin binding|negative regulation of apoptotic signaling pathway hsa04550 Signaling pathways regulating pluripotency of stem cells chromosome_remodelling_factor PCGF3 1062.734819 1051.858435 1073.611203 1.020680319 0.029531079 0.9077975 1 9.2679134 9.301283594 10336 polycomb group ring finger 3 "GO:0000805,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0031519,GO:0035102,GO:0036353,GO:0046872,GO:0060819" X chromosome|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|PcG protein complex|PRC1 complex|histone H2A-K119 monoubiquitination|metal ion binding|inactivation of X chromosome by genetic imprinting hsa04550 Signaling pathways regulating pluripotency of stem cells PCGF5 2839.32178 2815.359966 2863.283593 1.017022202 0.024351174 0.91953134 1 19.13289023 19.13296127 84333 polycomb group ring finger 5 "GO:0000805,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0005813,GO:0006357,GO:0031519,GO:0035102,GO:0036353,GO:0045944,GO:0046872,GO:0060819" X chromosome|protein binding|nucleus|nucleoplasm|Golgi apparatus|centrosome|regulation of transcription by RNA polymerase II|PcG protein complex|PRC1 complex|histone H2A-K119 monoubiquitination|positive regulation of transcription by RNA polymerase II|metal ion binding|inactivation of X chromosome by genetic imprinting hsa04550 Signaling pathways regulating pluripotency of stem cells PCGF6 893.8795705 883.3113864 904.4477546 1.023928559 0.034115059 0.895330906 1 21.0826052 21.22585098 84108 polycomb group ring finger 6 "GO:0000122,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0031519,GO:0035102,GO:0036353,GO:0045892,GO:0046872,GO:0070317" "negative regulation of transcription by RNA polymerase II|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|PcG protein complex|PRC1 complex|histone H2A-K119 monoubiquitination|negative regulation of transcription, DNA-templated|metal ion binding|negative regulation of G0 to G1 transition" hsa04550 Signaling pathways regulating pluripotency of stem cells other PCID2 1690.474798 1685.47049 1695.479106 1.005938174 0.008541638 0.974092669 1 8.759417887 8.663985436 55795 PCI domain containing 2 "GO:0000973,GO:0003690,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0006368,GO:0016973,GO:0043066,GO:0043488,GO:0044615,GO:0045579,GO:0045893,GO:0048536,GO:0070390,GO:0071033,GO:0090267,GO:2000117" "posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|double-stranded DNA binding|RNA binding|protein binding|nucleus|cytoplasm|transcription elongation from RNA polymerase II promoter|poly(A)+ mRNA export from nucleus|negative regulation of apoptotic process|regulation of mRNA stability|nuclear pore nuclear basket|positive regulation of B cell differentiation|positive regulation of transcription, DNA-templated|spleen development|transcription export complex 2|nuclear retention of pre-mRNA at the site of transcription|positive regulation of mitotic cell cycle spindle assembly checkpoint|negative regulation of cysteine-type endopeptidase activity" PCIF1 849.65695 807.3611729 891.9527272 1.104775356 0.143753043 0.567359802 1 15.06025234 16.35977796 63935 phosphorylated CTD interacting factor 1 "GO:0005634,GO:0005654,GO:0006417,GO:0010923,GO:0015630,GO:0016422,GO:0017148,GO:0045171,GO:0045727,GO:0080009,GO:0099122,GO:1904047,GO:1990269" nucleus|nucleoplasm|regulation of translation|negative regulation of phosphatase activity|microtubule cytoskeleton|mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|negative regulation of translation|intercellular bridge|positive regulation of translation|mRNA methylation|RNA polymerase II C-terminal domain binding|S-adenosyl-L-methionine binding|RNA polymerase II C-terminal domain phosphoserine binding PCK2 1364.900824 1641.773107 1088.028542 0.662715535 -0.593538357 0.013462313 0.686929575 31.30347026 20.39815159 5106 "phosphoenolpyruvate carboxykinase 2, mitochondrial" "GO:0004611,GO:0004613,GO:0005515,GO:0005525,GO:0005739,GO:0005759,GO:0005829,GO:0006094,GO:0006107,GO:0006116,GO:0019543,GO:0030145,GO:0032024,GO:0032496,GO:0032869,GO:0033993,GO:0042594,GO:0046327,GO:0070365,GO:0071333,GO:0071356,GO:0071549" phosphoenolpyruvate carboxykinase activity|phosphoenolpyruvate carboxykinase (GTP) activity|protein binding|GTP binding|mitochondrion|mitochondrial matrix|cytosol|gluconeogenesis|oxaloacetate metabolic process|NADH oxidation|propionate catabolic process|manganese ion binding|positive regulation of insulin secretion|response to lipopolysaccharide|cellular response to insulin stimulus|response to lipid|response to starvation|glycerol biosynthetic process from pyruvate|hepatocyte differentiation|cellular response to glucose stimulus|cellular response to tumor necrosis factor|cellular response to dexamethasone stimulus "hsa00010,hsa00020,hsa00620,hsa03320,hsa04068,hsa04151,hsa04152,hsa04910,hsa04920,hsa04922,hsa04931,hsa04964" Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Pyruvate metabolism|PPAR signaling pathway|FoxO signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance|Proximal tubule bicarbonate reclamation PCLAF 950.4984531 906.2004918 994.7964145 1.097766359 0.134571034 0.588032879 1 22.68398439 24.48501848 9768 PCNA clamp associated factor "GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0006260,GO:0006974,GO:0007098,GO:0009411,GO:0019985,GO:0048471,GO:0051726" chromatin binding|protein binding|nucleus|nucleoplasm|centrosome|DNA replication|cellular response to DNA damage stimulus|centrosome cycle|response to UV|translesion synthesis|perinuclear region of cytoplasm|regulation of cell cycle PCLO 774.9346201 788.633723 761.2355171 0.965258643 -0.051012528 0.844687093 1 1.786566447 1.695641553 27445 piccolo presynaptic cytomatrix protein "GO:0005509,GO:0005522,GO:0005544,GO:0005856,GO:0007010,GO:0014069,GO:0016079,GO:0017157,GO:0019933,GO:0030073,GO:0030424,GO:0035418,GO:0045202,GO:0048788,GO:0048790,GO:0070062,GO:0097091,GO:0098882,GO:0098978,GO:0098982,GO:0099526,GO:1904071" calcium ion binding|profilin binding|calcium-dependent phospholipid binding|cytoskeleton|cytoskeleton organization|postsynaptic density|synaptic vesicle exocytosis|regulation of exocytosis|cAMP-mediated signaling|insulin secretion|axon|protein localization to synapse|synapse|cytoskeleton of presynaptic active zone|maintenance of presynaptic active zone structure|extracellular exosome|synaptic vesicle clustering|structural constituent of presynaptic active zone|glutamatergic synapse|GABA-ergic synapse|presynapse to nucleus signaling pathway|presynaptic active zone assembly hsa04911 Insulin secretion PCM1 1891.880402 1875.86623 1907.894573 1.017073895 0.024424501 0.920154436 1 9.580967846 9.581490395 5108 pericentriolar material 1 "GO:0000086,GO:0000242,GO:0001764,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0007098,GO:0010389,GO:0016020,GO:0022027,GO:0031122,GO:0031965,GO:0032991,GO:0034451,GO:0034453,GO:0034454,GO:0035176,GO:0035735,GO:0035869,GO:0036064,GO:0042802,GO:0045177,GO:0050768,GO:0060271,GO:0071539,GO:0090316,GO:0097150,GO:0097711,GO:0097730,GO:1905515" G2/M transition of mitotic cell cycle|pericentriolar material|neuron migration|protein binding|cytoplasm|centrosome|centriole|cytosol|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|membrane|interkinetic nuclear migration|cytoplasmic microtubule organization|nuclear membrane|protein-containing complex|centriolar satellite|microtubule anchoring|microtubule anchoring at centrosome|social behavior|intraciliary transport involved in cilium assembly|ciliary transition zone|ciliary basal body|identical protein binding|apical part of cell|negative regulation of neurogenesis|cilium assembly|protein localization to centrosome|positive regulation of intracellular protein transport|neuronal stem cell population maintenance|ciliary basal body-plasma membrane docking|non-motile cilium|non-motile cilium assembly PCMT1 1646.956667 1451.377366 1842.535968 1.269508544 0.344270105 0.147626135 1 36.06021533 45.01270606 5110 protein-L-isoaspartate (D-aspartate) O-methyltransferase "GO:0004719,GO:0005515,GO:0005737,GO:0005829,GO:0006479,GO:0030091,GO:0045296,GO:0070062,GO:1903561" protein-L-isoaspartate (D-aspartate) O-methyltransferase activity|protein binding|cytoplasm|cytosol|protein methylation|protein repair|cadherin binding|extracellular exosome|extracellular vesicle PCMTD1 1114.686316 1128.849063 1100.52357 0.974907635 -0.036662554 0.883937411 1 12.8810348 12.34768107 115294 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 "GO:0004719,GO:0005515,GO:0005737,GO:0006479,GO:0016020" protein-L-isoaspartate (D-aspartate) O-methyltransferase activity|protein binding|cytoplasm|protein methylation|membrane PCMTD2 852.4605456 906.2004918 798.7205994 0.881395019 -0.182139352 0.467321709 1 12.53232825 10.86109299 55251 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 "GO:0004719,GO:0005515,GO:0005737,GO:0006479" protein-L-isoaspartate (D-aspartate) O-methyltransferase activity|protein binding|cytoplasm|protein methylation PCNA 2670.993612 2332.607925 3009.379298 1.290135074 0.36752212 0.120258681 1 88.98284332 112.8788665 5111 proliferating cell nuclear antigen "GO:0000083,GO:0000122,GO:0000307,GO:0000701,GO:0000723,GO:0000781,GO:0000785,GO:0003682,GO:0003684,GO:0005515,GO:0005634,GO:0005652,GO:0005654,GO:0005657,GO:0005813,GO:0006272,GO:0006283,GO:0006287,GO:0006296,GO:0006297,GO:0006298,GO:0006977,GO:0007507,GO:0008022,GO:0016032,GO:0016567,GO:0016604,GO:0019899,GO:0019985,GO:0030331,GO:0030337,GO:0030855,GO:0030894,GO:0030971,GO:0031297,GO:0032077,GO:0032139,GO:0032201,GO:0032355,GO:0032405,GO:0033683,GO:0034644,GO:0035035,GO:0042276,GO:0042769,GO:0042802,GO:0043596,GO:0043626,GO:0044849,GO:0044877,GO:0045739,GO:0045740,GO:0046686,GO:0070062,GO:0070182,GO:0070301,GO:0070557,GO:0070987,GO:0071466,GO:0071548,GO:0097421,GO:1900264,GO:1902065,GO:1902990" "regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|cyclin-dependent protein kinase holoenzyme complex|purine-specific mismatch base pair DNA N-glycosylase activity|telomere maintenance|chromosome, telomeric region|chromatin|chromatin binding|damaged DNA binding|protein binding|nucleus|nuclear lamina|nucleoplasm|replication fork|centrosome|leading strand elongation|transcription-coupled nucleotide-excision repair|base-excision repair, gap-filling|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|mismatch repair|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|heart development|protein C-terminus binding|viral process|protein ubiquitination|nuclear body|enzyme binding|translesion synthesis|estrogen receptor binding|DNA polymerase processivity factor activity|epithelial cell differentiation|replisome|receptor tyrosine kinase binding|replication fork processing|positive regulation of deoxyribonuclease activity|dinucleotide insertion or deletion binding|telomere maintenance via semi-conservative replication|response to estradiol|MutLalpha complex binding|nucleotide-excision repair, DNA incision|cellular response to UV|histone acetyltransferase binding|error-prone translesion synthesis|DNA damage response, detection of DNA damage|identical protein binding|nuclear replication fork|PCNA complex|estrous cycle|protein-containing complex binding|positive regulation of DNA repair|positive regulation of DNA replication|response to cadmium ion|extracellular exosome|DNA polymerase binding|cellular response to hydrogen peroxide|PCNA-p21 complex|error-free translesion synthesis|cellular response to xenobiotic stimulus|response to dexamethasone|liver regeneration|positive regulation of DNA-directed DNA polymerase activity|response to L-glutamate|mitotic telomere maintenance via semi-conservative replication" "hsa03030,hsa03410,hsa03420,hsa03430,hsa04110,hsa04530,hsa05161" DNA replication|Base excision repair|Nucleotide excision repair|Mismatch repair|Cell cycle|Tight junction|Hepatitis B PCNP 3644.410738 3310.596975 3978.224502 1.201663788 0.265033303 0.264666601 1 70.08348906 82.80753701 57092 PEST proteolytic signal containing nuclear protein "GO:0005515,GO:0005634,GO:0005654,GO:0007049,GO:0016567,GO:0016604,GO:0043161" protein binding|nucleus|nucleoplasm|cell cycle|protein ubiquitination|nuclear body|proteasome-mediated ubiquitin-dependent protein catabolic process PCNT 1042.213391 1093.474991 990.9517906 0.906240928 -0.142033447 0.563732713 1 5.102006516 4.546276648 5116 pericentrin "GO:0000086,GO:0000226,GO:0005515,GO:0005516,GO:0005813,GO:0005814,GO:0005829,GO:0005874,GO:0007052,GO:0007165,GO:0010389,GO:0016020,GO:0034451,GO:0060090,GO:0060271,GO:0090316,GO:0097711" G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|protein binding|calmodulin binding|centrosome|centriole|cytosol|microtubule|mitotic spindle organization|signal transduction|regulation of G2/M transition of mitotic cell cycle|membrane|centriolar satellite|molecular adaptor activity|cilium assembly|positive regulation of intracellular protein transport|ciliary basal body-plasma membrane docking PCNX1 3217.270651 3376.143049 3058.398252 0.905885268 -0.142599752 0.547745407 1 13.66127451 12.1684593 22990 pecanex 1 GO:0016021 integral component of membrane PCNX2 838.8206943 964.4636692 713.1777193 0.739455246 -0.435465262 0.08169673 1 5.869728979 4.267771136 80003 pecanex 2 "GO:0003674,GO:0005575,GO:0008150,GO:0016021" molecular_function|cellular_component|biological_process|integral component of membrane PCNX3 1273.473965 1335.891425 1211.056505 0.906553094 -0.141536579 0.558423512 1 7.940974616 7.078451011 399909 pecanex 3 GO:0016021 integral component of membrane PCNX4 3229.747399 3123.322476 3336.172323 1.068148534 0.095112278 0.688921939 1 9.218847415 9.682320495 64430 pecanex 4 "GO:0005515,GO:0016021" protein binding|integral component of membrane PCOLCE 115.694761 110.2838716 121.1056505 1.098126578 0.135044359 0.777543813 1 2.883707757 3.113686094 5118 procollagen C-endopeptidase enhancer "GO:0005201,GO:0005515,GO:0005518,GO:0005576,GO:0005615,GO:0007275,GO:0008201,GO:0010952,GO:0016504,GO:0062023,GO:0070062" extracellular matrix structural constituent|protein binding|collagen binding|extracellular region|extracellular space|multicellular organism development|heparin binding|positive regulation of peptidase activity|peptidase activator activity|collagen-containing extracellular matrix|extracellular exosome PCOLCE2 126.7279328 160.2237379 93.23212773 0.581887109 -0.781188808 0.069633341 1 4.509940092 2.580362299 26577 procollagen C-endopeptidase enhancer 2 "GO:0005518,GO:0005576,GO:0008201,GO:0010952,GO:0016504,GO:1990830" collagen binding|extracellular region|heparin binding|positive regulation of peptidase activity|peptidase activator activity|cellular response to leukemia inhibitory factor PCOTH 11.04826308 12.48496659 9.61155956 0.769850643 -0.377349516 0.799003187 1 0.61072385 0.462298555 542767 Pro-X-Gly collagen triple helix like repeat containing "GO:0005515,GO:0005737" protein binding|cytoplasm PCP2 9.527271215 10.40413883 8.650403604 0.831438695 -0.266318203 0.910300494 1 0.35868848 0.293237049 126006 Purkinje cell protein 2 "GO:0005085,GO:0005515,GO:0043025,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|neuronal cell body|regulation of catalytic activity PCP4L1 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.032796797 0.11916544 654790 Purkinje cell protein 4 like 1 PCSK1 8.125166245 11.44455271 4.80577978 0.419918533 -1.251818634 0.34524811 1 0.117141301 0.048366679 5122 proprotein convertase subtilisin/kexin type 1 "GO:0004252,GO:0005615,GO:0006508,GO:0007267,GO:0016020,GO:0016485,GO:0016486,GO:0030133,GO:0034774,GO:0042802,GO:0043005,GO:0043043" serine-type endopeptidase activity|extracellular space|proteolysis|cell-cell signaling|membrane|protein processing|peptide hormone processing|transport vesicle|secretory granule lumen|identical protein binding|neuron projection|peptide biosynthetic process PCSK1N 62.29649961 45.77821084 78.81478839 1.721665984 0.783805276 0.158205647 1 2.383511196 4.034941789 27344 proprotein convertase subtilisin/kexin type 1 inhibitor "GO:0002021,GO:0004866,GO:0004867,GO:0005102,GO:0005615,GO:0005802,GO:0007218,GO:0009409,GO:0010951,GO:0016486,GO:0030141" response to dietary excess|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|signaling receptor binding|extracellular space|trans-Golgi network|neuropeptide signaling pathway|response to cold|negative regulation of endopeptidase activity|peptide hormone processing|secretory granule PCSK4 45.36241391 30.1720026 60.55282523 2.006920987 1.004983818 0.107502545 1 0.504930801 0.996399078 54760 proprotein convertase subtilisin/kexin type 4 "GO:0001669,GO:0002080,GO:0004252,GO:0005515,GO:0005802,GO:0007339,GO:0007340,GO:0009566,GO:0016020,GO:0016485,GO:0016486,GO:0022414,GO:0030173,GO:0048240" acrosomal vesicle|acrosomal membrane|serine-type endopeptidase activity|protein binding|trans-Golgi network|binding of sperm to zona pellucida|acrosome reaction|fertilization|membrane|protein processing|peptide hormone processing|reproductive process|integral component of Golgi membrane|sperm capacitation PCSK5 7.808134538 3.121241648 12.49502743 4.003223344 2.001162108 0.144165166 1 0.01153566 0.045407067 5125 proprotein convertase subtilisin/kexin type 5 "GO:0001822,GO:0002001,GO:0004175,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005794,GO:0005796,GO:0005802,GO:0006465,GO:0007267,GO:0007507,GO:0007566,GO:0008233,GO:0009952,GO:0016020,GO:0016485,GO:0016486,GO:0019058,GO:0030141,GO:0030173,GO:0030323,GO:0032455,GO:0035108,GO:0042277,GO:0043043,GO:0048566,GO:0048706,GO:0051004,GO:0140447" kidney development|renin secretion into blood stream|endopeptidase activity|serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|Golgi apparatus|Golgi lumen|trans-Golgi network|signal peptide processing|cell-cell signaling|heart development|embryo implantation|peptidase activity|anterior/posterior pattern specification|membrane|protein processing|peptide hormone processing|viral life cycle|secretory granule|integral component of Golgi membrane|respiratory tube development|nerve growth factor processing|limb morphogenesis|peptide binding|peptide biosynthetic process|embryonic digestive tract development|embryonic skeletal system development|regulation of lipoprotein lipase activity|cytokine precursor processing PCSK6 27.37785349 37.45489978 17.30080721 0.461910386 -1.11431511 0.139999719 1 0.32892861 0.149393106 5046 proprotein convertase subtilisin/kexin type 6 "GO:0004175,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0005796,GO:0005886,GO:0008201,GO:0009100,GO:0009986,GO:0016020,GO:0016485,GO:0016486,GO:0030510,GO:0032455,GO:0032902,GO:0032940,GO:0048406,GO:0051004,GO:0062023,GO:0070268" endopeptidase activity|serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum|Golgi lumen|plasma membrane|heparin binding|glycoprotein metabolic process|cell surface|membrane|protein processing|peptide hormone processing|regulation of BMP signaling pathway|nerve growth factor processing|nerve growth factor production|secretion by cell|nerve growth factor binding|regulation of lipoprotein lipase activity|collagen-containing extracellular matrix|cornification PCSK7 789.8375678 776.1487565 803.5263792 1.03527368 0.050012202 0.847389954 1 7.113452281 7.241137162 9159 proprotein convertase subtilisin/kexin type 7 "GO:0004252,GO:0005515,GO:0005802,GO:0008233,GO:0016020,GO:0016485,GO:0016486,GO:0030173" serine-type endopeptidase activity|protein binding|trans-Golgi network|peptidase activity|membrane|protein processing|peptide hormone processing|integral component of Golgi membrane PCTP 330.5169188 299.6391982 361.3946395 1.206099341 0.27034874 0.378509758 1 4.837021565 5.736305629 58488 phosphatidylcholine transfer protein "GO:0005515,GO:0005829,GO:0006656,GO:0006869,GO:0008525,GO:0015914,GO:0031210,GO:0120163" protein binding|cytosol|phosphatidylcholine biosynthetic process|lipid transport|phosphatidylcholine transporter activity|phospholipid transport|phosphatidylcholine binding|negative regulation of cold-induced thermogenesis PCYOX1 1799.679241 1801.996845 1797.361638 0.997427739 -0.00371577 0.990157612 1 18.0125978 17.66562358 51449 prenylcysteine oxidase 1 "GO:0001735,GO:0005515,GO:0005764,GO:0005886,GO:0008555,GO:0030327,GO:0030328,GO:0034361,GO:0055114,GO:0070062,GO:1902476" prenylcysteine oxidase activity|protein binding|lysosome|plasma membrane|ATPase-coupled chloride transmembrane transporter activity|prenylated protein catabolic process|prenylcysteine catabolic process|very-low-density lipoprotein particle|oxidation-reduction process|extracellular exosome|chloride transmembrane transport hsa00900 Terpenoid backbone biosynthesis PCYOX1L 186.9140366 175.8299462 197.9981269 1.12607739 0.171305981 0.655301818 1 3.637101188 4.027122134 78991 prenylcysteine oxidase 1 like "GO:0001735,GO:0002576,GO:0005576,GO:0016020,GO:0030327,GO:0030328,GO:0031093,GO:0055114" prenylcysteine oxidase activity|platelet degranulation|extracellular region|membrane|prenylated protein catabolic process|prenylcysteine catabolic process|platelet alpha granule lumen|oxidation-reduction process PCYT1A 1524.432592 1691.712973 1357.15221 0.802235504 -0.317902279 0.182464701 1 16.0933355 12.69460295 5130 "phosphate cytidylyltransferase 1, choline, alpha" "GO:0004105,GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0005829,GO:0006656,GO:0006657,GO:0031210,GO:0042587,GO:0042802" choline-phosphate cytidylyltransferase activity|protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|phosphatidylcholine biosynthetic process|CDP-choline pathway|phosphatidylcholine binding|glycogen granule|identical protein binding "hsa00440,hsa00564,hsa05231" Phosphonate and phosphinate metabolism|Glycerophospholipid metabolism|Choline metabolism in cancer PCYT2 397.2669536 424.4888641 370.0450431 0.87174264 -0.198025816 0.497613623 1 4.016700443 3.442935702 5833 "phosphate cytidylyltransferase 2, ethanolamine" "GO:0004306,GO:0005515,GO:0005575,GO:0005789,GO:0006646,GO:0008654" ethanolamine-phosphate cytidylyltransferase activity|protein binding|cellular_component|endoplasmic reticulum membrane|phosphatidylethanolamine biosynthetic process|phospholipid biosynthetic process "hsa00440,hsa00564" Phosphonate and phosphinate metabolism|Glycerophospholipid metabolism PDAP1 2665.711055 2521.963252 2809.458859 1.113996747 0.15574502 0.510598644 1 51.68684469 56.61547067 11333 PDGFA associated protein 1 "GO:0003723,GO:0005515,GO:0005576,GO:0005829,GO:0005886,GO:0007165,GO:0043312,GO:1904813" RNA binding|protein binding|extracellular region|cytosol|plasma membrane|signal transduction|neutrophil degranulation|ficolin-1-rich granule lumen PDCD10 1267.049042 1179.829343 1354.268742 1.147851382 0.198935861 0.410076431 1 18.61227419 21.00662497 11235 programmed cell death 10 "GO:0000139,GO:0001525,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0008284,GO:0010628,GO:0010629,GO:0019901,GO:0030335,GO:0032874,GO:0033138,GO:0035023,GO:0036481,GO:0042542,GO:0042803,GO:0043066,GO:0043149,GO:0043406,GO:0044319,GO:0045747,GO:0047485,GO:0050821,GO:0051683,GO:0070062,GO:0071902,GO:0090051,GO:0090168,GO:0090316,GO:0090443,GO:1903358,GO:1903588,GO:1990830" "Golgi membrane|angiogenesis|protein binding|cytoplasm|Golgi apparatus|cytosol|plasma membrane|positive regulation of cell population proliferation|positive regulation of gene expression|negative regulation of gene expression|protein kinase binding|positive regulation of cell migration|positive regulation of stress-activated MAPK cascade|positive regulation of peptidyl-serine phosphorylation|regulation of Rho protein signal transduction|intrinsic apoptotic signaling pathway in response to hydrogen peroxide|response to hydrogen peroxide|protein homodimerization activity|negative regulation of apoptotic process|stress fiber assembly|positive regulation of MAP kinase activity|wound healing, spreading of cells|positive regulation of Notch signaling pathway|protein N-terminus binding|protein stabilization|establishment of Golgi localization|extracellular exosome|positive regulation of protein serine/threonine kinase activity|negative regulation of cell migration involved in sprouting angiogenesis|Golgi reassembly|positive regulation of intracellular protein transport|FAR/SIN/STRIPAK complex|regulation of Golgi organization|negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|cellular response to leukemia inhibitory factor" PDCD11 3320.632087 3780.86405 2860.400125 0.756546675 -0.402499003 0.089743128 1 30.87647519 22.96860513 22984 programmed cell death 11 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0006397,GO:0008134,GO:0032040" RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|rRNA processing|mRNA processing|transcription factor binding|small-subunit processome PDCD1LG2 326.9245457 369.3469283 284.502163 0.770284362 -0.376536959 0.219511563 1 7.806481875 5.912587968 80380 programmed cell death 1 ligand 2 "GO:0002250,GO:0003674,GO:0005515,GO:0005576,GO:0005886,GO:0006955,GO:0007166,GO:0009897,GO:0012505,GO:0016021,GO:0031295,GO:0032689,GO:0032693,GO:0042102,GO:0042130,GO:0046007,GO:0071222" adaptive immune response|molecular_function|protein binding|extracellular region|plasma membrane|immune response|cell surface receptor signaling pathway|external side of plasma membrane|endomembrane system|integral component of membrane|T cell costimulation|negative regulation of interferon-gamma production|negative regulation of interleukin-10 production|positive regulation of T cell proliferation|negative regulation of T cell proliferation|negative regulation of activated T cell proliferation|cellular response to lipopolysaccharide hsa04514 Cell adhesion molecules PDCD2 927.2772247 889.5538697 965.0005798 1.084814099 0.117447834 0.637809421 1 8.634749926 9.210352756 5134 programmed cell death 2 "GO:0003677,GO:0005515,GO:0005634,GO:0005737,GO:0006915,GO:0006919,GO:0019899,GO:0043065,GO:0046872,GO:0070062,GO:1901532,GO:1902035" DNA binding|protein binding|nucleus|cytoplasm|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|enzyme binding|positive regulation of apoptotic process|metal ion binding|extracellular exosome|regulation of hematopoietic progenitor cell differentiation|positive regulation of hematopoietic stem cell proliferation PDCD2L 123.0619465 114.4455271 131.678366 1.150576779 0.20235726 0.653927697 1 5.278951978 5.972202086 84306 programmed cell death 2 like "GO:0005515,GO:0005737,GO:0007049,GO:0016020" protein binding|cytoplasm|cell cycle|membrane PDCD4 753.3935138 677.3094376 829.47759 1.224665631 0.292387906 0.249271184 1 10.13934357 12.20951881 27250 programmed cell death 4 "GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0007569,GO:0030509,GO:0035722,GO:0043066,GO:0043508,GO:0045786,GO:0045892,GO:0050729,GO:0060940,GO:0071222,GO:1900016,GO:1901224,GO:1904706,GO:1904761,GO:1905064,GO:1905461,GO:2000353" "RNA binding|protein binding|nucleus|cytoplasm|cytosol|apoptotic process|cell aging|BMP signaling pathway|interleukin-12-mediated signaling pathway|negative regulation of apoptotic process|negative regulation of JUN kinase activity|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of inflammatory response|epithelial to mesenchymal transition involved in cardiac fibroblast development|cellular response to lipopolysaccharide|negative regulation of cytokine production involved in inflammatory response|positive regulation of NIK/NF-kappaB signaling|negative regulation of vascular associated smooth muscle cell proliferation|negative regulation of myofibroblast differentiation|negative regulation of vascular associated smooth muscle cell differentiation|positive regulation of vascular associated smooth muscle cell apoptotic process|positive regulation of endothelial cell apoptotic process" "hsa05205,hsa05206" Proteoglycans in cancer|MicroRNAs in cancer PDCD5 917.9185302 858.3414532 977.4956072 1.13881906 0.187538545 0.450565867 1 24.41796684 27.34232276 9141 programmed cell death 5 "GO:0003677,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0008201,GO:0008285,GO:0010628,GO:0010698,GO:0043065,GO:0043280,GO:0048487,GO:0070062,GO:0071560,GO:0090200,GO:1903638,GO:1903645" DNA binding|protein binding|nucleus|cytoplasm|cytosol|apoptotic process|heparin binding|negative regulation of cell population proliferation|positive regulation of gene expression|acetyltransferase activator activity|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|beta-tubulin binding|extracellular exosome|cellular response to transforming growth factor beta stimulus|positive regulation of release of cytochrome c from mitochondria|positive regulation of protein insertion into mitochondrial outer membrane|negative regulation of chaperone-mediated protein folding PDCD6 1212.109668 1163.182721 1261.036614 1.084125986 0.116532422 0.631968924 1 60.56285265 64.55906862 10016 programmed cell death 6 "GO:0000139,GO:0000287,GO:0001525,GO:0001938,GO:0005509,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005783,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0006919,GO:0010595,GO:0014029,GO:0014032,GO:0016567,GO:0030127,GO:0030674,GO:0030948,GO:0031410,GO:0031463,GO:0032007,GO:0034605,GO:0036324,GO:0042802,GO:0042803,GO:0043280,GO:0043495,GO:0045766,GO:0046983,GO:0048208,GO:0048306,GO:0051592,GO:0051898,GO:0070062,GO:0070971,GO:0097190,GO:1902527,GO:1990756" Golgi membrane|magnesium ion binding|angiogenesis|positive regulation of endothelial cell proliferation|calcium ion binding|protein binding|nucleus|nucleoplasm|cytoplasm|endosome|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|activation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of endothelial cell migration|neural crest formation|neural crest cell development|protein ubiquitination|COPII vesicle coat|protein-macromolecule adaptor activity|negative regulation of vascular endothelial growth factor receptor signaling pathway|cytoplasmic vesicle|Cul3-RING ubiquitin ligase complex|negative regulation of TOR signaling|cellular response to heat|vascular endothelial growth factor receptor-2 signaling pathway|identical protein binding|protein homodimerization activity|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein-membrane adaptor activity|positive regulation of angiogenesis|protein dimerization activity|COPII vesicle coating|calcium-dependent protein binding|response to calcium ion|negative regulation of protein kinase B signaling|extracellular exosome|endoplasmic reticulum exit site|apoptotic signaling pathway|positive regulation of protein monoubiquitination|ubiquitin ligase-substrate adaptor activity PDCD6IP 4610.24057 4631.922606 4588.558534 0.990637997 -0.013570136 0.95573177 1 37.36919068 36.39987169 10015 programmed cell death 6 interacting protein "GO:0000281,GO:0000915,GO:0001772,GO:0005515,GO:0005815,GO:0005829,GO:0005923,GO:0005925,GO:0006915,GO:0006997,GO:0007080,GO:0010824,GO:0015031,GO:0016020,GO:0019058,GO:0031871,GO:0036258,GO:0039702,GO:0042470,GO:0042641,GO:0042803,GO:0043231,GO:0045199,GO:0046755,GO:0048306,GO:0051260,GO:0061952,GO:0070062,GO:0070830,GO:0070971,GO:0090543,GO:0090559,GO:0090611,GO:1901673,GO:1903543,GO:1903551,GO:1903553,GO:1903561" mitotic cytokinesis|actomyosin contractile ring assembly|immunological synapse|protein binding|microtubule organizing center|cytosol|bicellular tight junction|focal adhesion|apoptotic process|nucleus organization|mitotic metaphase plate congression|regulation of centrosome duplication|protein transport|membrane|viral life cycle|proteinase activated receptor binding|multivesicular body assembly|viral budding via host ESCRT complex|melanosome|actomyosin|protein homodimerization activity|intracellular membrane-bounded organelle|maintenance of epithelial cell apical/basal polarity|viral budding|calcium-dependent protein binding|protein homooligomerization|midbody abscission|extracellular exosome|bicellular tight junction assembly|endoplasmic reticulum exit site|Flemming body|regulation of membrane permeability|ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway|regulation of mitotic spindle assembly|positive regulation of exosomal secretion|regulation of extracellular exosome assembly|positive regulation of extracellular exosome assembly|extracellular vesicle hsa04144 Endocytosis PDCD7 555.8771936 475.4691444 636.2852429 1.338226151 0.420321942 0.115464352 1 8.988634205 11.82753925 10081 programmed cell death 7 "GO:0000398,GO:0005654,GO:0005689,GO:0006915,GO:0008380,GO:0051384" "mRNA splicing, via spliceosome|nucleoplasm|U12-type spliceosomal complex|apoptotic process|RNA splicing|response to glucocorticoid" PDCL 778.4081064 715.8047513 841.0114615 1.174917406 0.232559342 0.357986747 1 12.66197679 14.62783421 5082 phosducin like "GO:0005515,GO:0005737,GO:0005829,GO:0005929,GO:0006457,GO:0007165,GO:0007601,GO:0008277,GO:0030030,GO:0044877,GO:0045880,GO:0061084,GO:1902605" protein binding|cytoplasm|cytosol|cilium|protein folding|signal transduction|visual perception|regulation of G protein-coupled receptor signaling pathway|cell projection organization|protein-containing complex binding|positive regulation of smoothened signaling pathway|negative regulation of protein refolding|heterotrimeric G-protein complex assembly PDCL3 369.9142522 324.6091314 415.219373 1.279136453 0.355170173 0.230189941 1 8.584634656 10.79716832 79031 phosducin like 3 "GO:0001525,GO:0001938,GO:0005515,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0006915,GO:0010628,GO:0030036,GO:0032991,GO:0034605,GO:0043184,GO:0044183,GO:0045766,GO:0048471,GO:0050730,GO:0050821,GO:0061077,GO:0097356,GO:1903645,GO:2000059" angiogenesis|positive regulation of endothelial cell proliferation|protein binding|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|apoptotic process|positive regulation of gene expression|actin cytoskeleton organization|protein-containing complex|cellular response to heat|vascular endothelial growth factor receptor 2 binding|protein folding chaperone|positive regulation of angiogenesis|perinuclear region of cytoplasm|regulation of peptidyl-tyrosine phosphorylation|protein stabilization|chaperone-mediated protein folding|perinucleolar compartment|negative regulation of chaperone-mediated protein folding|negative regulation of ubiquitin-dependent protein catabolic process PDE10A 1030.293905 957.180772 1103.407037 1.152767659 0.205101766 0.403769052 1 3.383650962 3.835292752 10846 phosphodiesterase 10A "GO:0004114,GO:0004118,GO:0005829,GO:0006198,GO:0007165,GO:0007186,GO:0010754,GO:0030552,GO:0030553,GO:0046069,GO:0046872,GO:0047555" "3',5'-cyclic-nucleotide phosphodiesterase activity|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|cytosol|cAMP catabolic process|signal transduction|G protein-coupled receptor signaling pathway|negative regulation of cGMP-mediated signaling|cAMP binding|cGMP binding|cGMP catabolic process|metal ion binding|3',5'-cyclic-GMP phosphodiesterase activity" "hsa00230,hsa04024,hsa05032" Purine metabolism|cAMP signaling pathway|Morphine addiction PDE11A 13.49078193 13.52538047 13.45618338 0.994883908 -0.007399906 1 1 0.073400925 0.071803418 50940 phosphodiesterase 11A "GO:0004112,GO:0004114,GO:0004115,GO:0004118,GO:0005575,GO:0005829,GO:0007165,GO:0007186,GO:0008152,GO:0010754,GO:0030553,GO:0043951,GO:0046872,GO:0047555" "cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|cellular_component|cytosol|signal transduction|G protein-coupled receptor signaling pathway|metabolic process|negative regulation of cGMP-mediated signaling|cGMP binding|negative regulation of cAMP-mediated signaling|metal ion binding|3',5'-cyclic-GMP phosphodiesterase activity" "hsa00230,hsa04934,hsa05032" Purine metabolism|Cushing syndrome|Morphine addiction PDE12 876.4950893 792.7953786 960.1948 1.211150854 0.27637857 0.267471096 1 3.908548015 4.654626844 201626 phosphodiesterase 12 "GO:0000175,GO:0000288,GO:0000958,GO:0004527,GO:0004535,GO:0005739,GO:0005759,GO:0005829,GO:0006397,GO:0034611,GO:0035457,GO:0044528,GO:0045070,GO:0046872,GO:0051607,GO:0060548,GO:0071346,GO:0071359,GO:0090305,GO:0090324,GO:0090503" "3'-5'-exoribonuclease activity|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|mitochondrial mRNA catabolic process|exonuclease activity|poly(A)-specific ribonuclease activity|mitochondrion|mitochondrial matrix|cytosol|mRNA processing|oligoribonucleotidase activity|cellular response to interferon-alpha|regulation of mitochondrial mRNA stability|positive regulation of viral genome replication|metal ion binding|defense response to virus|negative regulation of cell death|cellular response to interferon-gamma|cellular response to dsRNA|nucleic acid phosphodiester bond hydrolysis|negative regulation of oxidative phosphorylation|RNA phosphodiester bond hydrolysis, exonucleolytic" PDE1C 76.90695335 63.46524684 90.34865986 1.423592665 0.509536404 0.325374775 1 0.252762954 0.353810194 5137 phosphodiesterase 1C "GO:0004114,GO:0004117,GO:0005516,GO:0005829,GO:0007165,GO:0043025,GO:0046872,GO:0048101" "3',5'-cyclic-nucleotide phosphodiesterase activity|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|calmodulin binding|cytosol|signal transduction|neuronal cell body|metal ion binding|calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity" "hsa00230,hsa04020,hsa04740,hsa04742,hsa04924,hsa05032" Purine metabolism|Calcium signaling pathway|Olfactory transduction|Taste transduction|Renin secretion|Morphine addiction PDE2A 800.7172542 809.4420007 791.9925077 0.978442565 -0.031440928 0.905594317 1 9.012817001 8.670957735 5138 phosphodiesterase 2A "GO:0000122,GO:0000287,GO:0003170,GO:0003281,GO:0004114,GO:0004115,GO:0004118,GO:0005515,GO:0005634,GO:0005737,GO:0005741,GO:0005743,GO:0005759,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0007165,GO:0007186,GO:0007193,GO:0008270,GO:0010628,GO:0010752,GO:0010754,GO:0010821,GO:0019933,GO:0019934,GO:0030552,GO:0030553,GO:0030911,GO:0035904,GO:0036006,GO:0042301,GO:0042734,GO:0042803,GO:0043116,GO:0043117,GO:0043949,GO:0043951,GO:0046069,GO:0047555,GO:0048471,GO:0050729,GO:0061028,GO:0071260,GO:0071320,GO:0071321,GO:0071560,GO:0097060,GO:1904613" "negative regulation of transcription by RNA polymerase II|magnesium ion binding|heart valve development|ventricular septum development|3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|protein binding|nucleus|cytoplasm|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial matrix|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|zinc ion binding|positive regulation of gene expression|regulation of cGMP-mediated signaling|negative regulation of cGMP-mediated signaling|regulation of mitochondrion organization|cAMP-mediated signaling|cGMP-mediated signaling|cAMP binding|cGMP binding|TPR domain binding|aorta development|cellular response to macrophage colony-stimulating factor stimulus|phosphate ion binding|presynaptic membrane|protein homodimerization activity|negative regulation of vascular permeability|positive regulation of vascular permeability|regulation of cAMP-mediated signaling|negative regulation of cAMP-mediated signaling|cGMP catabolic process|3',5'-cyclic-GMP phosphodiesterase activity|perinuclear region of cytoplasm|positive regulation of inflammatory response|establishment of endothelial barrier|cellular response to mechanical stimulus|cellular response to cAMP|cellular response to cGMP|cellular response to transforming growth factor beta stimulus|synaptic membrane|cellular response to 2,3,7,8-tetrachlorodibenzodioxine" "hsa00230,hsa04022,hsa04740,hsa04925,hsa05032" Purine metabolism|cGMP-PKG signaling pathway|Olfactory transduction|Aldosterone synthesis and secretion|Morphine addiction PDE3A 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.008847662 0.010715838 5139 phosphodiesterase 3A "GO:0001556,GO:0004114,GO:0004115,GO:0004119,GO:0005515,GO:0005829,GO:0006629,GO:0007165,GO:0007186,GO:0016021,GO:0019933,GO:0019934,GO:0040020,GO:0042493,GO:0043066,GO:0043116,GO:0043117,GO:0043951,GO:0046872,GO:0060282,GO:0071321,GO:0071560" "oocyte maturation|3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|protein binding|cytosol|lipid metabolic process|signal transduction|G protein-coupled receptor signaling pathway|integral component of membrane|cAMP-mediated signaling|cGMP-mediated signaling|regulation of meiotic nuclear division|response to drug|negative regulation of apoptotic process|negative regulation of vascular permeability|positive regulation of vascular permeability|negative regulation of cAMP-mediated signaling|metal ion binding|positive regulation of oocyte development|cellular response to cGMP|cellular response to transforming growth factor beta stimulus" "hsa00230,hsa04022,hsa04024,hsa04924,hsa05032" Purine metabolism|cGMP-PKG signaling pathway|cAMP signaling pathway|Renin secretion|Morphine addiction PDE4A 50.68337022 43.69738307 57.66935736 1.31974396 0.400258063 0.516253556 1 0.37656209 0.488649498 5141 phosphodiesterase 4A "GO:0004114,GO:0004115,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006198,GO:0007165,GO:0007186,GO:0007608,GO:0010738,GO:0016020,GO:0030552,GO:0032587,GO:0035690,GO:0043949,GO:0046872,GO:0048471" "3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|cAMP catabolic process|signal transduction|G protein-coupled receptor signaling pathway|sensory perception of smell|regulation of protein kinase A signaling|membrane|cAMP binding|ruffle membrane|cellular response to drug|regulation of cAMP-mediated signaling|metal ion binding|perinuclear region of cytoplasm" "hsa00230,hsa04024,hsa04928,hsa05032" "Purine metabolism|cAMP signaling pathway|Parathyroid hormone synthesis, secretion and action|Morphine addiction" PDE4B 3.121241648 6.242483296 0 0 #NAME? 0.093640883 1 0.054109121 0 5142 phosphodiesterase 4B "GO:0000930,GO:0001780,GO:0004114,GO:0004115,GO:0005634,GO:0005813,GO:0005829,GO:0005891,GO:0006198,GO:0007165,GO:0007186,GO:0008021,GO:0014069,GO:0030018,GO:0030552,GO:0030593,GO:0032729,GO:0032743,GO:0035690,GO:0043015,GO:0043197,GO:0044325,GO:0046872,GO:0048471,GO:0050852,GO:0050900,GO:0060076,GO:0071222,GO:0071872,GO:0086004,GO:0140199,GO:1901841,GO:1901898" "gamma-tubulin complex|neutrophil homeostasis|3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|nucleus|centrosome|cytosol|voltage-gated calcium channel complex|cAMP catabolic process|signal transduction|G protein-coupled receptor signaling pathway|synaptic vesicle|postsynaptic density|Z disc|cAMP binding|neutrophil chemotaxis|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|cellular response to drug|gamma-tubulin binding|dendritic spine|ion channel binding|metal ion binding|perinuclear region of cytoplasm|T cell receptor signaling pathway|leukocyte migration|excitatory synapse|cellular response to lipopolysaccharide|cellular response to epinephrine stimulus|regulation of cardiac muscle cell contraction|negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process|regulation of high voltage-gated calcium channel activity|negative regulation of relaxation of cardiac muscle" "hsa00230,hsa04024,hsa04928,hsa05032" "Purine metabolism|cAMP signaling pathway|Parathyroid hormone synthesis, secretion and action|Morphine addiction" PDE4C 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.028209133 0.008541367 5143 phosphodiesterase 4C "GO:0004114,GO:0004115,GO:0005615,GO:0005634,GO:0005829,GO:0005929,GO:0006198,GO:0007165,GO:0007186,GO:0046872,GO:0048471" "3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|extracellular space|nucleus|cytosol|cilium|cAMP catabolic process|signal transduction|G protein-coupled receptor signaling pathway|metal ion binding|perinuclear region of cytoplasm" "hsa00230,hsa04024,hsa04928,hsa05032" "Purine metabolism|cAMP signaling pathway|Parathyroid hormone synthesis, secretion and action|Morphine addiction" PDE4D 381.3537745 359.9832034 402.7243456 1.118730935 0.161863096 0.585514484 1 1.056920391 1.162623514 5144 phosphodiesterase 4D "GO:0002027,GO:0004114,GO:0004115,GO:0005515,GO:0005634,GO:0005815,GO:0005829,GO:0005886,GO:0005891,GO:0006198,GO:0007165,GO:0007186,GO:0010469,GO:0010880,GO:0016324,GO:0019899,GO:0019933,GO:0030552,GO:0031698,GO:0032729,GO:0032743,GO:0032754,GO:0033137,GO:0034704,GO:0043951,GO:0044325,GO:0045822,GO:0046872,GO:0048471,GO:0050852,GO:0051117,GO:0060314,GO:0061028,GO:0071875,GO:0086004,GO:0086024,GO:0097110,GO:1901363,GO:1901844,GO:1901898" "regulation of heart rate|3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|protein binding|nucleus|microtubule organizing center|cytosol|plasma membrane|voltage-gated calcium channel complex|cAMP catabolic process|signal transduction|G protein-coupled receptor signaling pathway|regulation of signaling receptor activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|apical plasma membrane|enzyme binding|cAMP-mediated signaling|cAMP binding|beta-2 adrenergic receptor binding|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|positive regulation of interleukin-5 production|negative regulation of peptidyl-serine phosphorylation|calcium channel complex|negative regulation of cAMP-mediated signaling|ion channel binding|negative regulation of heart contraction|metal ion binding|perinuclear region of cytoplasm|T cell receptor signaling pathway|ATPase binding|regulation of ryanodine-sensitive calcium-release channel activity|establishment of endothelial barrier|adrenergic receptor signaling pathway|regulation of cardiac muscle cell contraction|adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate|scaffold protein binding|heterocyclic compound binding|regulation of cell communication by electrical coupling involved in cardiac conduction|negative regulation of relaxation of cardiac muscle" "hsa00230,hsa04024,hsa04928,hsa05032" "Purine metabolism|cAMP signaling pathway|Parathyroid hormone synthesis, secretion and action|Morphine addiction" PDE4DIP 6964.237113 7600.223413 6328.250814 0.832640104 -0.264235047 0.279561088 1 28.27338317 23.1476167 9659 phosphodiesterase 4D interacting protein "GO:0005515,GO:0005634,GO:0005737,GO:0005794,GO:0005813,GO:0019899,GO:0030016,GO:0034622,GO:0060090,GO:1903358" protein binding|nucleus|cytoplasm|Golgi apparatus|centrosome|enzyme binding|myofibril|cellular protein-containing complex assembly|molecular adaptor activity|regulation of Golgi organization PDE5A 270.3257847 296.5179566 244.1336128 0.823335004 -0.280448532 0.392774181 1 2.100984913 1.700868319 8654 phosphodiesterase 5A "GO:0004114,GO:0005515,GO:0005575,GO:0005829,GO:0007165,GO:0030553,GO:0046069,GO:0046872,GO:0047555" "3',5'-cyclic-nucleotide phosphodiesterase activity|protein binding|cellular_component|cytosol|signal transduction|cGMP binding|cGMP catabolic process|metal ion binding|3',5'-cyclic-GMP phosphodiesterase activity" "hsa00230,hsa04022" Purine metabolism|cGMP-PKG signaling pathway PDE6D 682.8774988 655.4607461 710.2942515 1.083656429 0.115907426 0.655828882 1 21.11088433 22.49413082 5147 phosphodiesterase 6D "GO:0005095,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005929,GO:0007601,GO:0030659,GO:0031267,GO:0031410,GO:0034260,GO:0050896" GTPase inhibitor activity|protein binding|cytoplasm|cytosol|cytoskeleton|cilium|visual perception|cytoplasmic vesicle membrane|small GTPase binding|cytoplasmic vesicle|negative regulation of GTPase activity|response to stimulus hsa00230 Purine metabolism PDE7A 992.5698199 1152.778582 832.3610579 0.722047643 -0.469834061 0.056105863 1 8.605633543 6.109699939 5150 phosphodiesterase 7A "GO:0004114,GO:0004115,GO:0005829,GO:0006198,GO:0007165,GO:0007186,GO:0019933,GO:0046872" "3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|cytosol|cAMP catabolic process|signal transduction|G protein-coupled receptor signaling pathway|cAMP-mediated signaling|metal ion binding" "hsa00230,hsa05032" Purine metabolism|Morphine addiction PDE7B 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.030933135 0.00936616 27115 phosphodiesterase 7B "GO:0004114,GO:0004115,GO:0005829,GO:0006198,GO:0007165,GO:0007186,GO:0007268,GO:0019933,GO:0045202,GO:0046872" "3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|cytosol|cAMP catabolic process|signal transduction|G protein-coupled receptor signaling pathway|chemical synaptic transmission|cAMP-mediated signaling|synapse|metal ion binding" "hsa00230,hsa05032" Purine metabolism|Morphine addiction PDE8A 1096.533179 1156.940237 1036.126121 0.895574453 -0.15911472 0.515490686 1 10.79625356 9.507053787 5151 phosphodiesterase 8A "GO:0001934,GO:0004114,GO:0004115,GO:0005829,GO:0006198,GO:0006355,GO:0007165,GO:0007186,GO:0019900,GO:0046872,GO:0047555,GO:0060548,GO:0070062,GO:0070374,GO:0071364,GO:1903206" "positive regulation of protein phosphorylation|3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|cytosol|cAMP catabolic process|regulation of transcription, DNA-templated|signal transduction|G protein-coupled receptor signaling pathway|kinase binding|metal ion binding|3',5'-cyclic-GMP phosphodiesterase activity|negative regulation of cell death|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|cellular response to epidermal growth factor stimulus|negative regulation of hydrogen peroxide-induced cell death" "hsa00230,hsa04927,hsa04934,hsa05032" Purine metabolism|Cortisol synthesis and secretion|Cushing syndrome|Morphine addiction PDF 30.70227037 36.41448589 24.99005486 0.686266859 -0.543158409 0.464786672 1 0.679739134 0.458676489 64146 "peptide deformylase, mitochondrial" "GO:0005739,GO:0006412,GO:0008284,GO:0018206,GO:0031365,GO:0042586,GO:0043686,GO:0046872" mitochondrion|translation|positive regulation of cell population proliferation|peptidyl-methionine modification|N-terminal protein amino acid modification|peptide deformylase activity|co-translational protein modification|metal ion binding PDGFA 294.399343 285.0734038 303.7252821 1.065428335 0.091433555 0.781709057 1 4.552317062 4.769006603 5154 platelet derived growth factor subunit A "GO:0000139,GO:0000165,GO:0001525,GO:0001775,GO:0001942,GO:0002053,GO:0002576,GO:0005161,GO:0005515,GO:0005518,GO:0005576,GO:0005615,GO:0005788,GO:0005796,GO:0005902,GO:0007267,GO:0008083,GO:0008284,GO:0009611,GO:0009887,GO:0009986,GO:0010512,GO:0010544,GO:0014068,GO:0014910,GO:0030031,GO:0030036,GO:0030198,GO:0030335,GO:0031093,GO:0031954,GO:0032956,GO:0035793,GO:0042060,GO:0042803,GO:0043406,GO:0043410,GO:0043588,GO:0046982,GO:0048008,GO:0048146,GO:0048286,GO:0048407,GO:0050730,GO:0050919,GO:0051781,GO:0051897,GO:0060683,GO:0070374,GO:0070851,GO:0072124,GO:1990401,GO:2000278" Golgi membrane|MAPK cascade|angiogenesis|cell activation|hair follicle development|positive regulation of mesenchymal cell proliferation|platelet degranulation|platelet-derived growth factor receptor binding|protein binding|collagen binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi lumen|microvillus|cell-cell signaling|growth factor activity|positive regulation of cell population proliferation|response to wounding|animal organ morphogenesis|cell surface|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|positive regulation of phosphatidylinositol 3-kinase signaling|regulation of smooth muscle cell migration|cell projection assembly|actin cytoskeleton organization|extracellular matrix organization|positive regulation of cell migration|platelet alpha granule lumen|positive regulation of protein autophosphorylation|regulation of actin cytoskeleton organization|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|wound healing|protein homodimerization activity|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|skin development|protein heterodimerization activity|platelet-derived growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|lung alveolus development|platelet-derived growth factor binding|regulation of peptidyl-tyrosine phosphorylation|negative chemotaxis|positive regulation of cell division|positive regulation of protein kinase B signaling|regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling|positive regulation of ERK1 and ERK2 cascade|growth factor receptor binding|regulation of glomerular mesangial cell proliferation|embryonic lung development|regulation of DNA biosynthetic process "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04072,hsa04151,hsa04510,hsa04540,hsa04630,hsa04810,hsa05200,hsa05202,hsa05206,hsa05214,hsa05215,hsa05218,hsa05231,hsa05418" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|JAK-STAT signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Transcriptional misregulation in cancer|MicroRNAs in cancer|Glioma|Prostate cancer|Melanoma|Choline metabolism in cancer|Fluid shear stress and atherosclerosis PDGFB 1473.139081 1770.784428 1175.493734 0.663826559 -0.591121743 0.013448389 0.686929575 24.9811024 16.30562321 5155 platelet derived growth factor subunit B "GO:0000139,GO:0000165,GO:0001892,GO:0001938,GO:0002548,GO:0002576,GO:0003104,GO:0005161,GO:0005515,GO:0005518,GO:0005576,GO:0005615,GO:0005737,GO:0005788,GO:0005796,GO:0006468,GO:0007507,GO:0008083,GO:0008284,GO:0009611,GO:0009986,GO:0010512,GO:0010544,GO:0010628,GO:0010629,GO:0010811,GO:0014068,GO:0014911,GO:0016176,GO:0016323,GO:0018105,GO:0018108,GO:0030097,GO:0030198,GO:0030335,GO:0031093,GO:0031954,GO:0032091,GO:0032147,GO:0032148,GO:0035655,GO:0035793,GO:0038001,GO:0042056,GO:0042802,GO:0042803,GO:0043406,GO:0043410,GO:0043536,GO:0043552,GO:0045737,GO:0045840,GO:0045892,GO:0045893,GO:0046982,GO:0048008,GO:0048146,GO:0048407,GO:0048661,GO:0050731,GO:0050918,GO:0050921,GO:0051781,GO:0051897,GO:0060326,GO:0061098,GO:0062023,GO:0070374,GO:0070528,GO:0070851,GO:0071363,GO:0071506,GO:0072126,GO:0072255,GO:0072593,GO:0090280,GO:1900127,GO:1902894,GO:1902895,GO:1904707,GO:1904754,GO:1905064,GO:1905176,GO:2000379,GO:2000573,GO:2000591" "Golgi membrane|MAPK cascade|embryonic placenta development|positive regulation of endothelial cell proliferation|monocyte chemotaxis|platelet degranulation|positive regulation of glomerular filtration|platelet-derived growth factor receptor binding|protein binding|collagen binding|extracellular region|extracellular space|cytoplasm|endoplasmic reticulum lumen|Golgi lumen|protein phosphorylation|heart development|growth factor activity|positive regulation of cell population proliferation|response to wounding|cell surface|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|positive regulation of gene expression|negative regulation of gene expression|positive regulation of cell-substrate adhesion|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of smooth muscle cell migration|superoxide-generating NADPH oxidase activator activity|basolateral plasma membrane|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|hemopoiesis|extracellular matrix organization|positive regulation of cell migration|platelet alpha granule lumen|positive regulation of protein autophosphorylation|negative regulation of protein binding|activation of protein kinase activity|activation of protein kinase B activity|interleukin-18-mediated signaling pathway|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|paracrine signaling|chemoattractant activity|identical protein binding|protein homodimerization activity|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|positive regulation of blood vessel endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of mitotic nuclear division|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein heterodimerization activity|platelet-derived growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|platelet-derived growth factor binding|positive regulation of smooth muscle cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive chemotaxis|positive regulation of chemotaxis|positive regulation of cell division|positive regulation of protein kinase B signaling|cell chemotaxis|positive regulation of protein tyrosine kinase activity|collagen-containing extracellular matrix|positive regulation of ERK1 and ERK2 cascade|protein kinase C signaling|growth factor receptor binding|cellular response to growth factor stimulus|cellular response to mycophenolic acid|positive regulation of glomerular mesangial cell proliferation|metanephric glomerular mesangial cell development|reactive oxygen species metabolic process|positive regulation of calcium ion import|positive regulation of hyaluronan biosynthetic process|negative regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of vascular associated smooth muscle cell migration|negative regulation of vascular associated smooth muscle cell differentiation|positive regulation of vascular associated smooth muscle cell dedifferentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of DNA biosynthetic process|positive regulation of metanephric mesenchymal cell migration" "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04072,hsa04151,hsa04510,hsa04540,hsa04630,hsa04810,hsa05167,hsa05200,hsa05206,hsa05211,hsa05214,hsa05215,hsa05218,hsa05231,hsa05418" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|JAK-STAT signaling pathway|Regulation of actin cytoskeleton|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|MicroRNAs in cancer|Renal cell carcinoma|Glioma|Prostate cancer|Melanoma|Choline metabolism in cancer|Fluid shear stress and atherosclerosis PDGFC 1097.376677 951.9787026 1242.774651 1.305464763 0.384563517 0.114852468 1 12.4431432 15.97226222 56034 platelet derived growth factor C "GO:0000139,GO:0005161,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005788,GO:0005829,GO:0005886,GO:0007171,GO:0007417,GO:0008083,GO:0008284,GO:0009887,GO:0009986,GO:0014068,GO:0030335,GO:0031954,GO:0042803,GO:0043406,GO:0048008,GO:0048146,GO:0048565,GO:0048568,GO:0050730,GO:0051781,GO:0060348,GO:0070062,GO:0070374,GO:0070851,GO:0071230,GO:0120162" Golgi membrane|platelet-derived growth factor receptor binding|protein binding|extracellular region|extracellular space|nucleus|endoplasmic reticulum lumen|cytosol|plasma membrane|activation of transmembrane receptor protein tyrosine kinase activity|central nervous system development|growth factor activity|positive regulation of cell population proliferation|animal organ morphogenesis|cell surface|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of cell migration|positive regulation of protein autophosphorylation|protein homodimerization activity|positive regulation of MAP kinase activity|platelet-derived growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|digestive tract development|embryonic organ development|regulation of peptidyl-tyrosine phosphorylation|positive regulation of cell division|bone development|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|growth factor receptor binding|cellular response to amino acid stimulus|positive regulation of cold-induced thermogenesis "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04072,hsa04151,hsa04510,hsa04540,hsa04810,hsa05215,hsa05218,hsa05231" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|Regulation of actin cytoskeleton|Prostate cancer|Melanoma|Choline metabolism in cancer PDGFD 37.90590963 48.89945248 26.91236677 0.550361311 -0.86154904 0.196183469 1 0.679956724 0.367959778 80310 platelet derived growth factor D "GO:0000139,GO:0005161,GO:0005576,GO:0005615,GO:0005788,GO:0007275,GO:0008083,GO:0008284,GO:0014068,GO:0030335,GO:0031954,GO:0036120,GO:0043406,GO:0048008,GO:0048146,GO:0048661,GO:0050730,GO:0051781,GO:0070301,GO:0070374,GO:0070851,GO:0071230,GO:0071560,GO:0071673,GO:0072126,GO:2000439" Golgi membrane|platelet-derived growth factor receptor binding|extracellular region|extracellular space|endoplasmic reticulum lumen|multicellular organism development|growth factor activity|positive regulation of cell population proliferation|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of cell migration|positive regulation of protein autophosphorylation|cellular response to platelet-derived growth factor stimulus|positive regulation of MAP kinase activity|platelet-derived growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of smooth muscle cell proliferation|regulation of peptidyl-tyrosine phosphorylation|positive regulation of cell division|cellular response to hydrogen peroxide|positive regulation of ERK1 and ERK2 cascade|growth factor receptor binding|cellular response to amino acid stimulus|cellular response to transforming growth factor beta stimulus|positive regulation of smooth muscle cell chemotaxis|positive regulation of glomerular mesangial cell proliferation|positive regulation of monocyte extravasation "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04072,hsa04151,hsa04510,hsa04540,hsa04810,hsa05215,hsa05218,hsa05231" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|Regulation of actin cytoskeleton|Prostate cancer|Melanoma|Choline metabolism in cancer PDGFRA 9.086322201 11.44455271 6.728091692 0.587885946 -0.766391806 0.566347083 1 0.075712749 0.043765639 5156 platelet derived growth factor receptor alpha "GO:0000165,GO:0001553,GO:0001701,GO:0001775,GO:0002244,GO:0004672,GO:0004714,GO:0005018,GO:0005021,GO:0005161,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005886,GO:0005887,GO:0005902,GO:0005929,GO:0007169,GO:0007204,GO:0007275,GO:0008210,GO:0008284,GO:0009897,GO:0010544,GO:0010863,GO:0014068,GO:0016020,GO:0016032,GO:0018108,GO:0019838,GO:0023019,GO:0030054,GO:0030198,GO:0030324,GO:0030325,GO:0030335,GO:0030539,GO:0031226,GO:0032991,GO:0033327,GO:0033674,GO:0034614,GO:0035790,GO:0038085,GO:0038091,GO:0042060,GO:0042475,GO:0042803,GO:0043235,GO:0043552,GO:0044877,GO:0046777,GO:0048008,GO:0048015,GO:0048146,GO:0048407,GO:0048557,GO:0048701,GO:0048704,GO:0050872,GO:0050920,GO:0051897,GO:0055003,GO:0060021,GO:0060325,GO:0060326,GO:0061298,GO:0070374,GO:0070527,GO:0071230,GO:0072277,GO:2000249,GO:2000739" MAPK cascade|luteinization|in utero embryonic development|cell activation|hematopoietic progenitor cell differentiation|protein kinase activity|transmembrane receptor protein tyrosine kinase activity|platelet-derived growth factor alpha-receptor activity|vascular endothelial growth factor-activated receptor activity|platelet-derived growth factor receptor binding|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|plasma membrane|integral component of plasma membrane|microvillus|cilium|transmembrane receptor protein tyrosine kinase signaling pathway|positive regulation of cytosolic calcium ion concentration|multicellular organism development|estrogen metabolic process|positive regulation of cell population proliferation|external side of plasma membrane|negative regulation of platelet activation|positive regulation of phospholipase C activity|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|viral process|peptidyl-tyrosine phosphorylation|growth factor binding|signal transduction involved in regulation of gene expression|cell junction|extracellular matrix organization|lung development|adrenal gland development|positive regulation of cell migration|male genitalia development|intrinsic component of plasma membrane|protein-containing complex|Leydig cell differentiation|positive regulation of kinase activity|cellular response to reactive oxygen species|platelet-derived growth factor receptor-alpha signaling pathway|vascular endothelial growth factor binding|positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway|wound healing|odontogenesis of dentin-containing tooth|protein homodimerization activity|receptor complex|positive regulation of phosphatidylinositol 3-kinase activity|protein-containing complex binding|protein autophosphorylation|platelet-derived growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of fibroblast proliferation|platelet-derived growth factor binding|embryonic digestive tract morphogenesis|embryonic cranial skeleton morphogenesis|embryonic skeletal system morphogenesis|white fat cell differentiation|regulation of chemotaxis|positive regulation of protein kinase B signaling|cardiac myofibril assembly|roof of mouth development|face morphogenesis|cell chemotaxis|retina vasculature development in camera-type eye|positive regulation of ERK1 and ERK2 cascade|platelet aggregation|cellular response to amino acid stimulus|metanephric glomerular capillary formation|regulation of actin cytoskeleton reorganization|regulation of mesenchymal stem cell differentiation "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04072,hsa04144,hsa04151,hsa04510,hsa04540,hsa04630,hsa04810,hsa05163,hsa05200,hsa05206,hsa05214,hsa05215,hsa05218,hsa05230,hsa05231" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|Endocytosis|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|JAK-STAT signaling pathway|Regulation of actin cytoskeleton|Human cytomegalovirus infection|Pathways in cancer|MicroRNAs in cancer|Glioma|Prostate cancer|Melanoma|Central carbon metabolism in cancer|Choline metabolism in cancer PDGFRB 49.11771897 53.06110801 45.17432993 0.851364241 -0.2321516 0.724918323 1 0.493856612 0.413416167 5159 platelet derived growth factor receptor beta "GO:0000165,GO:0004713,GO:0004714,GO:0004992,GO:0005017,GO:0005019,GO:0005102,GO:0005161,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005794,GO:0005886,GO:0005887,GO:0005925,GO:0006024,GO:0007165,GO:0007169,GO:0007186,GO:0007275,GO:0007568,GO:0008284,GO:0008584,GO:0009636,GO:0009986,GO:0010863,GO:0014068,GO:0014911,GO:0016020,GO:0016324,GO:0016477,GO:0018108,GO:0019838,GO:0019899,GO:0019901,GO:0030335,GO:0031226,GO:0031410,GO:0032355,GO:0032516,GO:0032526,GO:0032956,GO:0032967,GO:0033674,GO:0034405,GO:0035025,GO:0035441,GO:0035789,GO:0035791,GO:0035793,GO:0035909,GO:0036120,GO:0038085,GO:0038091,GO:0042060,GO:0042542,GO:0043065,GO:0043066,GO:0043202,GO:0043231,GO:0043235,GO:0043406,GO:0043548,GO:0043552,GO:0043627,GO:0045840,GO:0046488,GO:0046777,GO:0048008,GO:0048015,GO:0048146,GO:0048407,GO:0048661,GO:0048839,GO:0050921,GO:0051897,GO:0055003,GO:0055093,GO:0060326,GO:0060437,GO:0060981,GO:0061298,GO:0070374,GO:0071670,GO:0072075,GO:0072262,GO:0072277,GO:0072278,GO:0072284,GO:0090280,GO:2000379,GO:2000491,GO:2000573" MAPK cascade|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|platelet activating factor receptor activity|platelet-derived growth factor-activated receptor activity|platelet-derived growth factor beta-receptor activity|signaling receptor binding|platelet-derived growth factor receptor binding|protein binding|ATP binding|nucleus|cytoplasm|Golgi apparatus|plasma membrane|integral component of plasma membrane|focal adhesion|glycosaminoglycan biosynthetic process|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|G protein-coupled receptor signaling pathway|multicellular organism development|aging|positive regulation of cell population proliferation|male gonad development|response to toxic substance|cell surface|positive regulation of phospholipase C activity|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of smooth muscle cell migration|membrane|apical plasma membrane|cell migration|peptidyl-tyrosine phosphorylation|growth factor binding|enzyme binding|protein kinase binding|positive regulation of cell migration|intrinsic component of plasma membrane|cytoplasmic vesicle|response to estradiol|positive regulation of phosphoprotein phosphatase activity|response to retinoic acid|regulation of actin cytoskeleton organization|positive regulation of collagen biosynthetic process|positive regulation of kinase activity|response to fluid shear stress|positive regulation of Rho protein signal transduction|cell migration involved in vasculogenesis|metanephric mesenchymal cell migration|platelet-derived growth factor receptor-beta signaling pathway|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|aorta morphogenesis|cellular response to platelet-derived growth factor stimulus|vascular endothelial growth factor binding|positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway|wound healing|response to hydrogen peroxide|positive regulation of apoptotic process|negative regulation of apoptotic process|lysosomal lumen|intracellular membrane-bounded organelle|receptor complex|positive regulation of MAP kinase activity|phosphatidylinositol 3-kinase binding|positive regulation of phosphatidylinositol 3-kinase activity|response to estrogen|positive regulation of mitotic nuclear division|phosphatidylinositol metabolic process|protein autophosphorylation|platelet-derived growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of fibroblast proliferation|platelet-derived growth factor binding|positive regulation of smooth muscle cell proliferation|inner ear development|positive regulation of chemotaxis|positive regulation of protein kinase B signaling|cardiac myofibril assembly|response to hyperoxia|cell chemotaxis|lung growth|cell migration involved in coronary angiogenesis|retina vasculature development in camera-type eye|positive regulation of ERK1 and ERK2 cascade|smooth muscle cell chemotaxis|metanephric mesenchyme development|metanephric glomerular mesangial cell proliferation involved in metanephros development|metanephric glomerular capillary formation|metanephric comma-shaped body morphogenesis|metanephric S-shaped body morphogenesis|positive regulation of calcium ion import|positive regulation of reactive oxygen species metabolic process|positive regulation of hepatic stellate cell activation|positive regulation of DNA biosynthetic process "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04072,hsa04151,hsa04510,hsa04540,hsa04630,hsa04810,hsa05165,hsa05200,hsa05206,hsa05214,hsa05215,hsa05218,hsa05230,hsa05231" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|JAK-STAT signaling pathway|Regulation of actin cytoskeleton|Human papillomavirus infection|Pathways in cancer|MicroRNAs in cancer|Glioma|Prostate cancer|Melanoma|Central carbon metabolism in cancer|Choline metabolism in cancer PDGFRL 40.1106547 43.69738307 36.52392633 0.835837841 -0.258705019 0.718091355 1 1.217144584 1.000311769 5157 platelet derived growth factor receptor like "GO:0004992,GO:0005019,GO:0005575,GO:0005576,GO:0007186,GO:0008150,GO:0035791" platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|cellular_component|extracellular region|G protein-coupled receptor signaling pathway|biological_process|platelet-derived growth factor receptor-beta signaling pathway PDHA1 2521.102358 2409.598552 2632.606163 1.092549695 0.127698903 0.589781816 1 37.0379741 39.78868649 5160 pyruvate dehydrogenase E1 subunit alpha 1 "GO:0004739,GO:0005515,GO:0005634,GO:0005730,GO:0005739,GO:0005759,GO:0005967,GO:0006006,GO:0006086,GO:0006090,GO:0006099,GO:0034604,GO:0045254,GO:0061732" pyruvate dehydrogenase (acetyl-transferring) activity|protein binding|nucleus|nucleolus|mitochondrion|mitochondrial matrix|mitochondrial pyruvate dehydrogenase complex|glucose metabolic process|acetyl-CoA biosynthetic process from pyruvate|pyruvate metabolic process|tricarboxylic acid cycle|pyruvate dehydrogenase (NAD+) activity|pyruvate dehydrogenase complex|mitochondrial acetyl-CoA biosynthetic process from pyruvate "hsa00010,hsa00020,hsa00620,hsa04066,hsa04922,hsa05230" Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Pyruvate metabolism|HIF-1 signaling pathway|Glucagon signaling pathway|Central carbon metabolism in cancer PDHB 1123.808466 951.9787026 1295.638229 1.360994973 0.444661738 0.067788693 1 33.71290889 45.11530799 5162 pyruvate dehydrogenase E1 subunit beta "GO:0004739,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0005967,GO:0006006,GO:0006086,GO:0006090,GO:0006099,GO:0034604,GO:0045254,GO:0061732" pyruvate dehydrogenase (acetyl-transferring) activity|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|mitochondrial pyruvate dehydrogenase complex|glucose metabolic process|acetyl-CoA biosynthetic process from pyruvate|pyruvate metabolic process|tricarboxylic acid cycle|pyruvate dehydrogenase (NAD+) activity|pyruvate dehydrogenase complex|mitochondrial acetyl-CoA biosynthetic process from pyruvate "hsa00010,hsa00020,hsa00620,hsa04066,hsa04922,hsa05230" Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Pyruvate metabolism|HIF-1 signaling pathway|Glucagon signaling pathway|Central carbon metabolism in cancer PDHX 773.8149483 784.4720675 763.1578291 0.972829831 -0.039740626 0.88002439 1 15.74495391 15.06084891 8050 pyruvate dehydrogenase complex component X "GO:0005515,GO:0005739,GO:0005759,GO:0006090,GO:0016746,GO:0034604,GO:0045254,GO:0061732" "protein binding|mitochondrion|mitochondrial matrix|pyruvate metabolic process|transferase activity, transferring acyl groups|pyruvate dehydrogenase (NAD+) activity|pyruvate dehydrogenase complex|mitochondrial acetyl-CoA biosynthetic process from pyruvate" "hsa00010,hsa00020,hsa00620" Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Pyruvate metabolism PDIA3 10602.30649 10050.39811 11154.21487 1.109828163 0.150336319 0.551940305 1 145.7530639 159.0540063 2923 protein disulfide isomerase family A member 3 "GO:0002474,GO:0002479,GO:0003723,GO:0003756,GO:0004197,GO:0004629,GO:0005515,GO:0005615,GO:0005634,GO:0005783,GO:0005788,GO:0005925,GO:0006457,GO:0006508,GO:0009986,GO:0015036,GO:0015037,GO:0018215,GO:0034975,GO:0034976,GO:0042470,GO:0042802,GO:0042824,GO:0045335,GO:0055038,GO:0055114,GO:0070062,GO:0098761,GO:2001238" "antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|RNA binding|protein disulfide isomerase activity|cysteine-type endopeptidase activity|phospholipase C activity|protein binding|extracellular space|nucleus|endoplasmic reticulum|endoplasmic reticulum lumen|focal adhesion|protein folding|proteolysis|cell surface|disulfide oxidoreductase activity|peptide disulfide oxidoreductase activity|protein phosphopantetheinylation|protein folding in endoplasmic reticulum|response to endoplasmic reticulum stress|melanosome|identical protein binding|MHC class I peptide loading complex|phagocytic vesicle|recycling endosome membrane|oxidation-reduction process|extracellular exosome|cellular response to interleukin-7|positive regulation of extrinsic apoptotic signaling pathway" "hsa04141,hsa04612,hsa05163,hsa05168,hsa05169,hsa05170" Protein processing in endoplasmic reticulum|Antigen processing and presentation|Human cytomegalovirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection PDIA4 7564.186514 7630.395415 7497.977613 0.98264601 -0.025256303 0.91863711 1 145.8524997 140.9230878 9601 protein disulfide isomerase family A member 4 "GO:0003723,GO:0003756,GO:0005515,GO:0005615,GO:0005783,GO:0005788,GO:0006457,GO:0009306,GO:0009986,GO:0015037,GO:0018215,GO:0034976,GO:0042470,GO:0055114,GO:0061077" RNA binding|protein disulfide isomerase activity|protein binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|protein folding|protein secretion|cell surface|peptide disulfide oxidoreductase activity|protein phosphopantetheinylation|response to endoplasmic reticulum stress|melanosome|oxidation-reduction process|chaperone-mediated protein folding "hsa04141,hsa04918,hsa05110" Protein processing in endoplasmic reticulum|Thyroid hormone synthesis|Vibrio cholerae infection PDIA5 1011.125506 920.7662861 1101.484726 1.19626961 0.258542574 0.292876755 1 26.64837549 31.34519584 10954 protein disulfide isomerase family A member 5 "GO:0003756,GO:0005515,GO:0005788,GO:0005789,GO:0006457,GO:0015037,GO:0016491,GO:0018215,GO:0036498,GO:0055114" protein disulfide isomerase activity|protein binding|endoplasmic reticulum lumen|endoplasmic reticulum membrane|protein folding|peptide disulfide oxidoreductase activity|oxidoreductase activity|protein phosphopantetheinylation|IRE1-mediated unfolded protein response|oxidation-reduction process PDIA6 6425.36493 6069.774591 6780.95527 1.11716756 0.159845587 0.51099072 1 102.5428028 112.6405283 10130 protein disulfide isomerase family A member 6 "GO:0003756,GO:0005515,GO:0005615,GO:0005783,GO:0005788,GO:0005789,GO:0005793,GO:0005829,GO:0005886,GO:0006457,GO:0015037,GO:0018215,GO:0034663,GO:0036498,GO:0042470,GO:0043687,GO:0044267,GO:0055114,GO:0070062" protein disulfide isomerase activity|protein binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|cytosol|plasma membrane|protein folding|peptide disulfide oxidoreductase activity|protein phosphopantetheinylation|endoplasmic reticulum chaperone complex|IRE1-mediated unfolded protein response|melanosome|post-translational protein modification|cellular protein metabolic process|oxidation-reduction process|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum PDIK1L 80.70188738 87.39476614 74.00900861 0.846835707 -0.239845992 0.649535334 1 0.705185673 0.58718347 149420 PDLIM1 interacting kinase 1 like "GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006468,GO:0051321,GO:0106310,GO:0106311" protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|protein phosphorylation|meiotic cell cycle|protein serine kinase activity|protein threonine kinase activity PDK1 923.3684342 850.0181421 996.7187264 1.172585239 0.229692801 0.354530417 1 8.480819962 9.778076825 5163 pyruvate dehydrogenase kinase 1 "GO:0004672,GO:0004740,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0005967,GO:0006006,GO:0006468,GO:0008283,GO:0008631,GO:0010510,GO:0010906,GO:0097411" protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|mitochondrial pyruvate dehydrogenase complex|glucose metabolic process|protein phosphorylation|cell population proliferation|intrinsic apoptotic signaling pathway in response to oxidative stress|regulation of acetyl-CoA biosynthetic process from pyruvate|regulation of glucose metabolic process|hypoxia-inducible factor-1alpha signaling pathway "hsa04066,hsa04360,hsa05230" HIF-1 signaling pathway|Axon guidance|Central carbon metabolism in cancer PDK2 421.6179146 420.3272086 422.9086206 1.006141435 0.008833121 0.984737082 1 5.907845824 5.844661533 5164 pyruvate dehydrogenase kinase 2 "GO:0004672,GO:0004740,GO:0005515,GO:0005524,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0005967,GO:0006006,GO:0006111,GO:0006468,GO:0006885,GO:0008286,GO:0010510,GO:0010565,GO:0010906,GO:0031670,GO:0034614,GO:0042593,GO:0042803,GO:0050848,GO:0072332" protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity|protein binding|ATP binding|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|mitochondrial pyruvate dehydrogenase complex|glucose metabolic process|regulation of gluconeogenesis|protein phosphorylation|regulation of pH|insulin receptor signaling pathway|regulation of acetyl-CoA biosynthetic process from pyruvate|regulation of cellular ketone metabolic process|regulation of glucose metabolic process|cellular response to nutrient|cellular response to reactive oxygen species|glucose homeostasis|protein homodimerization activity|regulation of calcium-mediated signaling|intrinsic apoptotic signaling pathway by p53 class mediator PDK3 715.2498304 622.1675018 808.332159 1.299219513 0.377645206 0.139300305 1 2.539692219 3.244403056 5165 pyruvate dehydrogenase kinase 3 "GO:0004672,GO:0004674,GO:0004740,GO:0005515,GO:0005524,GO:0005730,GO:0005739,GO:0005759,GO:0006006,GO:0006468,GO:0010510,GO:0010906,GO:0018105,GO:0035357,GO:0071333,GO:0071398,GO:0097411,GO:2000377" protein kinase activity|protein serine/threonine kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity|protein binding|ATP binding|nucleolus|mitochondrion|mitochondrial matrix|glucose metabolic process|protein phosphorylation|regulation of acetyl-CoA biosynthetic process from pyruvate|regulation of glucose metabolic process|peptidyl-serine phosphorylation|peroxisome proliferator activated receptor signaling pathway|cellular response to glucose stimulus|cellular response to fatty acid|hypoxia-inducible factor-1alpha signaling pathway|regulation of reactive oxygen species metabolic process PDK4 184.1645468 141.496288 226.8328056 1.603100751 0.680865098 0.069734938 1 2.097027724 3.30549244 5166 pyruvate dehydrogenase kinase 4 "GO:0004672,GO:0004740,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0006006,GO:0006468,GO:0006885,GO:0008286,GO:0009267,GO:0010510,GO:0010565,GO:0010906,GO:0042304,GO:0042593,GO:0042594,GO:0045124,GO:0046320,GO:0071398,GO:0072593,GO:2000811" protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|glucose metabolic process|protein phosphorylation|regulation of pH|insulin receptor signaling pathway|cellular response to starvation|regulation of acetyl-CoA biosynthetic process from pyruvate|regulation of cellular ketone metabolic process|regulation of glucose metabolic process|regulation of fatty acid biosynthetic process|glucose homeostasis|response to starvation|regulation of bone resorption|regulation of fatty acid oxidation|cellular response to fatty acid|reactive oxygen species metabolic process|negative regulation of anoikis PDLIM1 7103.362422 6710.669543 7496.055301 1.11703538 0.159674881 0.514069844 1 249.7462342 274.3071044 9124 PDZ and LIM domain 1 "GO:0001666,GO:0001725,GO:0003713,GO:0003779,GO:0005515,GO:0005667,GO:0005737,GO:0005856,GO:0005912,GO:0005925,GO:0006357,GO:0006979,GO:0007507,GO:0010761,GO:0030011,GO:0030018,GO:0030036,GO:0030950,GO:0031941,GO:0043149,GO:0045893,GO:0046872,GO:0051371,GO:0061061,GO:0098609,GO:0098641" "response to hypoxia|stress fiber|transcription coactivator activity|actin binding|protein binding|transcription regulator complex|cytoplasm|cytoskeleton|adherens junction|focal adhesion|regulation of transcription by RNA polymerase II|response to oxidative stress|heart development|fibroblast migration|maintenance of cell polarity|Z disc|actin cytoskeleton organization|establishment or maintenance of actin cytoskeleton polarity|filamentous actin|stress fiber assembly|positive regulation of transcription, DNA-templated|metal ion binding|muscle alpha-actinin binding|muscle structure development|cell-cell adhesion|cadherin binding involved in cell-cell adhesion" PDLIM2 629.8459589 575.3488771 684.3430407 1.189440126 0.250282651 0.337995234 1 5.238920342 6.12710833 64236 PDZ and LIM domain 2 "GO:0001725,GO:0003779,GO:0005515,GO:0005634,GO:0005912,GO:0007507,GO:0030018,GO:0030036,GO:0031941,GO:0046872,GO:0051371,GO:0061061" stress fiber|actin binding|protein binding|nucleus|adherens junction|heart development|Z disc|actin cytoskeleton organization|filamentous actin|metal ion binding|muscle alpha-actinin binding|muscle structure development PDLIM3 43.23189635 49.93986637 36.52392633 0.731358111 -0.451350097 0.488409741 1 0.891370864 0.641002458 27295 PDZ and LIM domain 3 "GO:0001725,GO:0003779,GO:0005515,GO:0005829,GO:0005912,GO:0007507,GO:0030018,GO:0030036,GO:0031941,GO:0046872,GO:0051371,GO:0061061" stress fiber|actin binding|protein binding|cytosol|adherens junction|heart development|Z disc|actin cytoskeleton organization|filamentous actin|metal ion binding|muscle alpha-actinin binding|muscle structure development PDLIM4 950.4487633 930.1300111 970.7675156 1.043690134 0.061693447 0.80643637 1 21.75255442 22.3230237 8572 PDZ and LIM domain 4 "GO:0001725,GO:0003779,GO:0005515,GO:0005634,GO:0005737,GO:0005856,GO:0005912,GO:0007507,GO:0019903,GO:0030018,GO:0030027,GO:0030036,GO:0031532,GO:0031901,GO:0031905,GO:0031941,GO:0034777,GO:0042803,GO:0043197,GO:0045211,GO:0046872,GO:0048471,GO:0051371,GO:0051393,GO:0055038,GO:0061061,GO:0098976" stress fiber|actin binding|protein binding|nucleus|cytoplasm|cytoskeleton|adherens junction|heart development|protein phosphatase binding|Z disc|lamellipodium|actin cytoskeleton organization|actin cytoskeleton reorganization|early endosome membrane|early endosome lumen|filamentous actin|recycling endosome lumen|protein homodimerization activity|dendritic spine|postsynaptic membrane|metal ion binding|perinuclear region of cytoplasm|muscle alpha-actinin binding|alpha-actinin binding|recycling endosome membrane|muscle structure development|excitatory chemical synaptic transmission PDLIM5 3480.824913 3482.265265 3479.384561 0.99917275 -0.001193964 0.997371311 1 21.44496851 21.06867251 10611 PDZ and LIM domain 5 "GO:0001725,GO:0003779,GO:0005080,GO:0005515,GO:0005829,GO:0005912,GO:0007507,GO:0014069,GO:0015629,GO:0016020,GO:0030018,GO:0030036,GO:0031941,GO:0042805,GO:0042995,GO:0046872,GO:0047485,GO:0051371,GO:0051963,GO:0061001,GO:0061049,GO:0061061,GO:0098609,GO:0098641,GO:0098793" stress fiber|actin binding|protein kinase C binding|protein binding|cytosol|adherens junction|heart development|postsynaptic density|actin cytoskeleton|membrane|Z disc|actin cytoskeleton organization|filamentous actin|actinin binding|cell projection|metal ion binding|protein N-terminus binding|muscle alpha-actinin binding|regulation of synapse assembly|regulation of dendritic spine morphogenesis|cell growth involved in cardiac muscle cell development|muscle structure development|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|presynapse PDLIM7 2251.380454 2204.637017 2298.123891 1.042404656 0.059915432 0.801436093 1 56.64777355 58.06178272 9260 PDZ and LIM domain 7 "GO:0001503,GO:0001725,GO:0001726,GO:0003779,GO:0005515,GO:0005654,GO:0005829,GO:0005912,GO:0005925,GO:0006898,GO:0007411,GO:0007507,GO:0015629,GO:0030018,GO:0030036,GO:0031941,GO:0045669,GO:0046872,GO:0051371,GO:0061061" ossification|stress fiber|ruffle|actin binding|protein binding|nucleoplasm|cytosol|adherens junction|focal adhesion|receptor-mediated endocytosis|axon guidance|heart development|actin cytoskeleton|Z disc|actin cytoskeleton organization|filamentous actin|positive regulation of osteoblast differentiation|metal ion binding|muscle alpha-actinin binding|muscle structure development PDP1 2855.699831 3018.240674 2693.158989 0.892294313 -0.16440845 0.487473763 1 35.44849416 31.10119634 54704 pyruvate dehydrogenase phosphatase catalytic subunit 1 "GO:0004722,GO:0004724,GO:0004741,GO:0005515,GO:0005739,GO:0005759,GO:0006470,GO:0010510,GO:0035970,GO:0046872,GO:1904184" protein serine/threonine phosphatase activity|magnesium-dependent protein serine/threonine phosphatase activity|[pyruvate dehydrogenase (lipoamide)] phosphatase activity|protein binding|mitochondrion|mitochondrial matrix|protein dephosphorylation|regulation of acetyl-CoA biosynthetic process from pyruvate|peptidyl-threonine dephosphorylation|metal ion binding|positive regulation of pyruvate dehydrogenase activity PDP2 630.3309529 663.7840571 596.8778487 0.899204858 -0.153278265 0.559259189 1 4.999990846 4.420781318 57546 pyruvate dehyrogenase phosphatase catalytic subunit 2 "GO:0004724,GO:0004741,GO:0005739,GO:0005759,GO:0006470,GO:0010510,GO:0046872,GO:1904184" magnesium-dependent protein serine/threonine phosphatase activity|[pyruvate dehydrogenase (lipoamide)] phosphatase activity|mitochondrion|mitochondrial matrix|protein dephosphorylation|regulation of acetyl-CoA biosynthetic process from pyruvate|metal ion binding|positive regulation of pyruvate dehydrogenase activity PDPK1 993.5416511 1026.888502 960.1948 0.935052635 -0.096880517 0.696417554 1 4.479577572 4.118549582 5170 3-phosphoinositide dependent protein kinase 1 "GO:0002223,GO:0003323,GO:0004674,GO:0004676,GO:0005158,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0006468,GO:0006469,GO:0006972,GO:0007173,GO:0010518,GO:0010667,GO:0014069,GO:0016004,GO:0016020,GO:0016477,GO:0018105,GO:0018107,GO:0019722,GO:0019901,GO:0030036,GO:0030168,GO:0030512,GO:0031295,GO:0031410,GO:0032148,GO:0032869,GO:0034122,GO:0035556,GO:0038095,GO:0042995,GO:0043122,GO:0043204,GO:0043274,GO:0043304,GO:0043524,GO:0043536,GO:0045766,GO:0046777,GO:0048041,GO:0050852,GO:0051281,GO:0071364,GO:0097191,GO:0106310,GO:0106311,GO:1903078,GO:1903672,GO:1905564,GO:1990416,GO:2000352" stimulatory C-type lectin receptor signaling pathway|type B pancreatic cell development|protein serine/threonine kinase activity|3-phosphoinositide-dependent protein kinase activity|insulin receptor binding|protein binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|focal adhesion|protein phosphorylation|negative regulation of protein kinase activity|hyperosmotic response|epidermal growth factor receptor signaling pathway|positive regulation of phospholipase activity|negative regulation of cardiac muscle cell apoptotic process|postsynaptic density|phospholipase activator activity|membrane|cell migration|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|calcium-mediated signaling|protein kinase binding|actin cytoskeleton organization|platelet activation|negative regulation of transforming growth factor beta receptor signaling pathway|T cell costimulation|cytoplasmic vesicle|activation of protein kinase B activity|cellular response to insulin stimulus|negative regulation of toll-like receptor signaling pathway|intracellular signal transduction|Fc-epsilon receptor signaling pathway|cell projection|regulation of I-kappaB kinase/NF-kappaB signaling|perikaryon|phospholipase binding|regulation of mast cell degranulation|negative regulation of neuron apoptotic process|positive regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|protein autophosphorylation|focal adhesion assembly|T cell receptor signaling pathway|positive regulation of release of sequestered calcium ion into cytosol|cellular response to epidermal growth factor stimulus|extrinsic apoptotic signaling pathway|protein serine kinase activity|protein threonine kinase activity|positive regulation of protein localization to plasma membrane|positive regulation of sprouting angiogenesis|positive regulation of vascular endothelial cell proliferation|cellular response to brain-derived neurotrophic factor stimulus|negative regulation of endothelial cell apoptotic process "hsa01524,hsa03320,hsa04068,hsa04071,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04510,hsa04660,hsa04664,hsa04722,hsa04910,hsa04919,hsa04931,hsa04960,hsa05145,hsa05205,hsa05213,hsa05215,hsa05223,hsa05231" Platinum drug resistance|PPAR signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Focal adhesion|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|Neurotrophin signaling pathway|Insulin signaling pathway|Thyroid hormone signaling pathway|Insulin resistance|Aldosterone-regulated sodium reabsorption|Toxoplasmosis|Proteoglycans in cancer|Endometrial cancer|Prostate cancer|Non-small cell lung cancer|Choline metabolism in cancer PDPR 1156.743206 1311.961906 1001.524506 0.763379258 -0.389528108 0.108606558 1 5.969562251 4.480784108 55066 pyruvate dehydrogenase phosphatase regulatory subunit "GO:0005737,GO:0005739,GO:0005759,GO:0010510,GO:0016491,GO:0055114" cytoplasm|mitochondrion|mitochondrial matrix|regulation of acetyl-CoA biosynthetic process from pyruvate|oxidoreductase activity|oxidation-reduction process PDRG1 484.7963123 464.0245917 505.5680329 1.089528533 0.123703979 0.658028247 1 12.65413368 13.55633227 81572 p53 and DNA damage regulated 1 "GO:0005515,GO:0005737,GO:0006457,GO:0016272,GO:0051082" protein binding|cytoplasm|protein folding|prefoldin complex|unfolded protein binding PDS5A 4569.098948 4662.094608 4476.103287 0.960105631 -0.058734954 0.806706802 1 32.65617806 30.8287241 23244 PDS5 cohesin associated factor A "GO:0000775,GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0005886,GO:0006281,GO:0007064,GO:0008156,GO:0051301" "chromosome, centromeric region|chromatin|protein binding|nucleus|nucleoplasm|chromosome|cytosol|plasma membrane|DNA repair|mitotic sister chromatid cohesion|negative regulation of DNA replication|cell division" PDS5B 1067.04493 1089.313335 1044.776524 0.959114784 -0.060224612 0.808662955 1 9.520905769 8.978835827 23047 PDS5 cohesin associated factor B "GO:0000775,GO:0000785,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006281,GO:0007064,GO:0008283,GO:0008285,GO:0042127,GO:0051301" "chromosome, centromeric region|chromatin|DNA binding|protein binding|nucleus|nucleoplasm|chromosome|cytosol|DNA repair|mitotic sister chromatid cohesion|cell population proliferation|negative regulation of cell population proliferation|regulation of cell population proliferation|cell division" PDSS1 170.302013 156.0620824 184.5419436 1.182490588 0.2418287 0.53868036 1 2.057496667 2.392257978 23590 decaprenyl diphosphate synthase subunit 1 "GO:0000010,GO:0004659,GO:0005515,GO:0005759,GO:0006744,GO:0008299,GO:0046872,GO:0046982,GO:0050347,GO:0097269,GO:1990234" trans-hexaprenyltranstransferase activity|prenyltransferase activity|protein binding|mitochondrial matrix|ubiquinone biosynthetic process|isoprenoid biosynthetic process|metal ion binding|protein heterodimerization activity|trans-octaprenyltranstransferase activity|all-trans-decaprenyl-diphosphate synthase activity|transferase complex hsa00900 Terpenoid backbone biosynthesis PDSS2 201.0439123 193.5169822 208.5708425 1.0777909 0.108077311 0.777206771 1 2.243677095 2.377749208 57107 decaprenyl diphosphate synthase subunit 2 "GO:0000010,GO:0004659,GO:0005515,GO:0005759,GO:0005829,GO:0006744,GO:0008299,GO:0021549,GO:0046982,GO:0050347,GO:0050878,GO:0097269,GO:1990234" trans-hexaprenyltranstransferase activity|prenyltransferase activity|protein binding|mitochondrial matrix|cytosol|ubiquinone biosynthetic process|isoprenoid biosynthetic process|cerebellum development|protein heterodimerization activity|trans-octaprenyltranstransferase activity|regulation of body fluid levels|all-trans-decaprenyl-diphosphate synthase activity|transferase complex hsa00900 Terpenoid backbone biosynthesis PDXDC1 2416.499905 2401.275241 2431.724569 1.012680482 0.018179051 0.940544946 1 21.01880372 20.92915107 23042 pyridoxal dependent decarboxylase domain containing 1 "GO:0001667,GO:0005783,GO:0005794,GO:0008117,GO:0016831,GO:0019752,GO:0030149,GO:0030170,GO:0043231,GO:0045296" ameboidal-type cell migration|endoplasmic reticulum|Golgi apparatus|sphinganine-1-phosphate aldolase activity|carboxy-lyase activity|carboxylic acid metabolic process|sphingolipid catabolic process|pyridoxal phosphate binding|intracellular membrane-bounded organelle|cadherin binding PDXK 2434.921613 2203.596603 2666.246622 1.209952229 0.274950088 0.244834916 1 12.05431536 14.34108308 8566 pyridoxal kinase "GO:0000287,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0008270,GO:0008478,GO:0009443,GO:0016310,GO:0030170,GO:0030955,GO:0031402,GO:0031403,GO:0034774,GO:0035580,GO:0042803,GO:0042816,GO:0043312,GO:0070062" magnesium ion binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytosol|zinc ion binding|pyridoxal kinase activity|pyridoxal 5'-phosphate salvage|phosphorylation|pyridoxal phosphate binding|potassium ion binding|sodium ion binding|lithium ion binding|secretory granule lumen|specific granule lumen|protein homodimerization activity|vitamin B6 metabolic process|neutrophil degranulation|extracellular exosome hsa00750 Vitamin B6 metabolism PDXP 639.4870866 601.3592242 677.614949 1.126805613 0.172238655 0.510069796 1 15.9510122 17.67292471 57026 pyridoxal phosphatase "GO:0000287,GO:0004647,GO:0004721,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0006114,GO:0006470,GO:0006650,GO:0007088,GO:0015629,GO:0016311,GO:0016791,GO:0030027,GO:0030496,GO:0030836,GO:0031072,GO:0031247,GO:0031258,GO:0032154,GO:0032361,GO:0032465,GO:0032587,GO:0033883,GO:0042803,GO:0043136,GO:0070938,GO:0071318" magnesium ion binding|phosphoserine phosphatase activity|phosphoprotein phosphatase activity|protein binding|cytoplasm|cytosol|plasma membrane|cell-cell junction|glycerol biosynthetic process|protein dephosphorylation|glycerophospholipid metabolic process|regulation of mitotic nuclear division|actin cytoskeleton|dephosphorylation|phosphatase activity|lamellipodium|midbody|positive regulation of actin filament depolymerization|heat shock protein binding|actin rod assembly|lamellipodium membrane|cleavage furrow|pyridoxal phosphate catabolic process|regulation of cytokinesis|ruffle membrane|pyridoxal phosphatase activity|protein homodimerization activity|glycerol-3-phosphatase activity|contractile ring|cellular response to ATP hsa00750 Vitamin B6 metabolism PDZD11 1432.511291 1221.445898 1643.576685 1.34559925 0.428248807 0.07351224 1 58.0983268 76.86887766 51248 PDZ domain containing 11 "GO:0005515,GO:0005576,GO:0005829,GO:0005911,GO:0005912,GO:0006768,GO:0007269,GO:0015939,GO:0016323,GO:0019730,GO:0034220,GO:0045199,GO:0045202,GO:0046930,GO:0046931,GO:0055085,GO:0098793,GO:1903361" protein binding|extracellular region|cytosol|cell-cell junction|adherens junction|biotin metabolic process|neurotransmitter secretion|pantothenate metabolic process|basolateral plasma membrane|antimicrobial humoral response|ion transmembrane transport|maintenance of epithelial cell apical/basal polarity|synapse|pore complex|pore complex assembly|transmembrane transport|presynapse|protein localization to basolateral plasma membrane PDZD2 323.9819415 317.3262342 330.6376489 1.041948674 0.059284212 0.856636797 1 1.309551338 1.341652466 23037 PDZ domain containing 2 "GO:0005576,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0005911,GO:0007155,GO:0034451,GO:0043231" extracellular region|nucleus|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|cell-cell junction|cell adhesion|centriolar satellite|intracellular membrane-bounded organelle PDZD4 142.1366106 85.31393838 198.9592829 2.332084143 1.221619843 0.003484402 0.377418567 1.076116306 2.46759912 57595 PDZ domain containing 4 GO:0005938 cell cortex PDZD7 224.7457187 210.1636043 239.327833 1.138769169 0.187475339 0.597128058 1 1.760484272 1.971237846 79955 PDZ domain containing 7 "GO:0001917,GO:0002141,GO:0002142,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005886,GO:0005929,GO:0007605,GO:0032391,GO:0032420,GO:0032426,GO:0042802,GO:0045184,GO:0050910,GO:0060088,GO:0060117,GO:1990696" photoreceptor inner segment|stereocilia ankle link|stereocilia ankle link complex|protein binding|extracellular space|nucleus|nucleoplasm|plasma membrane|cilium|sensory perception of sound|photoreceptor connecting cilium|stereocilium|stereocilium tip|identical protein binding|establishment of protein localization|detection of mechanical stimulus involved in sensory perception of sound|auditory receptor cell stereocilium organization|auditory receptor cell development|USH2 complex PDZD8 946.9362625 900.9984224 992.8741025 1.101970967 0.140086214 0.572812948 1 4.91110508 5.321334475 118987 PDZ domain containing 8 "GO:0005739,GO:0005789,GO:0006869,GO:0007010,GO:0008289,GO:0016020,GO:0016021,GO:0016032,GO:0022604,GO:0035556,GO:0044233,GO:0046872,GO:0051560,GO:1990456" mitochondrion|endoplasmic reticulum membrane|lipid transport|cytoskeleton organization|lipid binding|membrane|integral component of membrane|viral process|regulation of cell morphogenesis|intracellular signal transduction|mitochondria-associated endoplasmic reticulum membrane|metal ion binding|mitochondrial calcium ion homeostasis|mitochondrion-endoplasmic reticulum membrane tethering PDZK1IP1 23.37471381 33.29324424 13.45618338 0.404171588 -1.306960188 0.104535127 1 2.120285507 0.842619109 10158 PDZK1 interacting protein 1 "GO:0005515,GO:0016021,GO:0070062" protein binding|integral component of membrane|extracellular exosome PEA15 8477.043212 8229.673812 8724.412613 1.060116453 0.084222753 0.734190462 1 160.2344275 167.0246562 8682 proliferation and apoptosis adaptor protein 15 "GO:0000165,GO:0000187,GO:0005515,GO:0005654,GO:0005829,GO:0005875,GO:0006915,GO:0008643,GO:0043278,GO:0046325,GO:1902042,GO:1902043" MAPK cascade|activation of MAPK activity|protein binding|nucleoplasm|cytosol|microtubule associated complex|apoptotic process|carbohydrate transport|response to morphine|negative regulation of glucose import|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors PEAK1 1049.074846 1160.061479 938.088213 0.808653877 -0.306405767 0.210692926 1 4.283267541 3.405720896 79834 pseudopodium enriched atypical kinase 1 "GO:0004672,GO:0004715,GO:0005515,GO:0005524,GO:0005737,GO:0005925,GO:0006468,GO:0015629,GO:0016477,GO:0018108,GO:0034446,GO:0042802,GO:0046777,GO:0048041,GO:0051893" protein kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|cytoplasm|focal adhesion|protein phosphorylation|actin cytoskeleton|cell migration|peptidyl-tyrosine phosphorylation|substrate adhesion-dependent cell spreading|identical protein binding|protein autophosphorylation|focal adhesion assembly|regulation of focal adhesion assembly PEAR1 665.6207366 744.93634 586.3051332 0.787054009 -0.345465455 0.18090554 1 6.16561466 4.771468849 375033 platelet endothelial aggregation receptor 1 "GO:0001891,GO:0005515,GO:0014065,GO:0016020,GO:0016021,GO:0038023,GO:0043491,GO:0043654,GO:0070527" phagocytic cup|protein binding|phosphatidylinositol 3-kinase signaling|membrane|integral component of membrane|signaling receptor activity|protein kinase B signaling|recognition of apoptotic cell|platelet aggregation PEBP1 2819.041197 2358.618272 3279.464122 1.3904175 0.475518146 0.044647118 1 87.96304837 120.2587472 5037 phosphatidylethanolamine binding protein 1 "GO:0000165,GO:0003723,GO:0004867,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0008429,GO:0010951,GO:0019899,GO:0019901,GO:0043409,GO:0070062" MAPK cascade|RNA binding|serine-type endopeptidase inhibitor activity|protein binding|ATP binding|nucleus|cytosol|phosphatidylethanolamine binding|negative regulation of endopeptidase activity|enzyme binding|protein kinase binding|negative regulation of MAPK cascade|extracellular exosome PECAM1 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.022771692 0 5175 platelet and endothelial cell adhesion molecule 1 "GO:0001934,GO:0002576,GO:0004888,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0005911,GO:0006909,GO:0007156,GO:0007159,GO:0007165,GO:0007166,GO:0008037,GO:0030198,GO:0030335,GO:0030667,GO:0031092,GO:0032991,GO:0035633,GO:0035696,GO:0042803,GO:0043312,GO:0045121,GO:0050731,GO:0050900,GO:0050904,GO:0061028,GO:0070062,GO:0070830,GO:0072011,GO:0072672,GO:0098609,GO:0098742,GO:0150107" positive regulation of protein phosphorylation|platelet degranulation|transmembrane signaling receptor activity|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|cell-cell junction|phagocytosis|homophilic cell adhesion via plasma membrane adhesion molecules|leukocyte cell-cell adhesion|signal transduction|cell surface receptor signaling pathway|cell recognition|extracellular matrix organization|positive regulation of cell migration|secretory granule membrane|platelet alpha granule membrane|protein-containing complex|maintenance of blood-brain barrier|monocyte extravasation|protein homodimerization activity|neutrophil degranulation|membrane raft|positive regulation of peptidyl-tyrosine phosphorylation|leukocyte migration|diapedesis|establishment of endothelial barrier|extracellular exosome|bicellular tight junction assembly|glomerular endothelium development|neutrophil extravasation|cell-cell adhesion|cell-cell adhesion via plasma-membrane adhesion molecules|positive regulation of protein localization to cell-cell junction "hsa04514,hsa04670,hsa05144,hsa05418" Cell adhesion molecules|Leukocyte transendothelial migration|Malaria|Fluid shear stress and atherosclerosis PECR 386.3281309 339.1749257 433.4813362 1.278046528 0.353940359 0.226061929 1 3.659014031 4.59813712 55825 peroxisomal trans-2-enoyl-CoA reductase "GO:0001561,GO:0005102,GO:0005739,GO:0005777,GO:0005778,GO:0005829,GO:0006625,GO:0006633,GO:0008670,GO:0019166,GO:0033306,GO:0055114" "fatty acid alpha-oxidation|signaling receptor binding|mitochondrion|peroxisome|peroxisomal membrane|cytosol|protein targeting to peroxisome|fatty acid biosynthetic process|2,4-dienoyl-CoA reductase (NADPH) activity|trans-2-enoyl-CoA reductase (NADPH) activity|phytol metabolic process|oxidation-reduction process" hsa04146 Peroxisome PEDS1 550.6745098 565.9851522 535.3638675 0.945897371 -0.080244434 0.769714319 1 3.92127578 3.647057277 387521 plasmanylethanolamine desaturase 1 "GO:0005515,GO:0005783,GO:0005789,GO:0006631,GO:0008611,GO:0016021,GO:0016491,GO:0050207,GO:0055114" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|fatty acid metabolic process|ether lipid biosynthetic process|integral component of membrane|oxidoreductase activity|plasmanylethanolamine desaturase activity|oxidation-reduction process hsa00565 Ether lipid metabolism PEF1 776.1039817 768.8658593 783.3421041 1.01882805 0.026910585 0.920477964 1 19.26429943 19.29857722 553115 penta-EF-hand domain containing 1 "GO:0000139,GO:0003723,GO:0005509,GO:0005515,GO:0005737,GO:0005783,GO:0006888,GO:0014029,GO:0014032,GO:0016567,GO:0030127,GO:0031463,GO:0042802,GO:0046982,GO:0046983,GO:0048208,GO:0048306,GO:0051592,GO:0070062,GO:1902527,GO:1990756" Golgi membrane|RNA binding|calcium ion binding|protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum to Golgi vesicle-mediated transport|neural crest formation|neural crest cell development|protein ubiquitination|COPII vesicle coat|Cul3-RING ubiquitin ligase complex|identical protein binding|protein heterodimerization activity|protein dimerization activity|COPII vesicle coating|calcium-dependent protein binding|response to calcium ion|extracellular exosome|positive regulation of protein monoubiquitination|ubiquitin ligase-substrate adaptor activity PEG10 1242.879906 1428.488261 1057.271552 0.740133175 -0.434143212 0.072165984 1 11.51946102 8.383265276 23089 paternally expressed 10 "GO:0003677,GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0008270,GO:0030154,GO:0030512" DNA binding|RNA binding|protein binding|nucleoplasm|cytoplasm|cytosol|apoptotic process|zinc ion binding|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway PELI1 403.0489806 387.0339643 419.0639968 1.082757679 0.114710404 0.697134512 1 3.963025967 4.219192776 57162 pellino E3 ubiquitin protein ligase 1 "GO:0000209,GO:0000778,GO:0001819,GO:0005515,GO:0005829,GO:0008063,GO:0008592,GO:0030890,GO:0031398,GO:0032088,GO:0032496,GO:0034141,GO:0034145,GO:0034450,GO:0042130,GO:0043123,GO:0043161,GO:0043331,GO:0060546,GO:0061630,GO:0070498,GO:0070534,GO:0070936" protein polyubiquitination|condensed nuclear chromosome kinetochore|positive regulation of cytokine production|protein binding|cytosol|Toll signaling pathway|regulation of Toll signaling pathway|positive regulation of B cell proliferation|positive regulation of protein ubiquitination|negative regulation of NF-kappaB transcription factor activity|response to lipopolysaccharide|positive regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|ubiquitin-ubiquitin ligase activity|negative regulation of T cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB signaling|proteasome-mediated ubiquitin-dependent protein catabolic process|response to dsRNA|negative regulation of necroptotic process|ubiquitin protein ligase activity|interleukin-1-mediated signaling pathway|protein K63-linked ubiquitination|protein K48-linked ubiquitination PELI2 116.8144328 114.4455271 119.1833385 1.041397961 0.058521487 0.915015579 1 0.269028209 0.27547724 57161 pellino E3 ubiquitin protein ligase family member 2 "GO:0000209,GO:0001934,GO:0005515,GO:0005829,GO:0008063,GO:0008592,GO:0034450,GO:0043123,GO:0043410,GO:0061630,GO:0070498" protein polyubiquitination|positive regulation of protein phosphorylation|protein binding|cytosol|Toll signaling pathway|regulation of Toll signaling pathway|ubiquitin-ubiquitin ligase activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAPK cascade|ubiquitin protein ligase activity|interleukin-1-mediated signaling pathway PELI3 311.64543 321.4878897 301.8029702 0.938769328 -0.091157389 0.777946735 1 5.740119707 5.298476588 246330 pellino E3 ubiquitin protein ligase family member 3 "GO:0000209,GO:0005515,GO:0005829,GO:0008063,GO:0008592,GO:0010804,GO:0061630,GO:0070498,GO:0070534,GO:2001237" protein polyubiquitination|protein binding|cytosol|Toll signaling pathway|regulation of Toll signaling pathway|negative regulation of tumor necrosis factor-mediated signaling pathway|ubiquitin protein ligase activity|interleukin-1-mediated signaling pathway|protein K63-linked ubiquitination|negative regulation of extrinsic apoptotic signaling pathway PELO 1073.679287 1023.767261 1123.591313 1.097506588 0.134229599 0.584606947 1 12.49978886 13.48903841 53918 pelota mRNA surveillance and ribosome rescue factor "GO:0001833,GO:0004519,GO:0005515,GO:0005634,GO:0005737,GO:0007049,GO:0007492,GO:0019827,GO:0030513,GO:0032790,GO:0046872,GO:0051276,GO:0051301,GO:0060231,GO:0070481,GO:0070651,GO:0070966,GO:0071025,GO:0090305" "inner cell mass cell proliferation|endonuclease activity|protein binding|nucleus|cytoplasm|cell cycle|endoderm development|stem cell population maintenance|positive regulation of BMP signaling pathway|ribosome disassembly|metal ion binding|chromosome organization|cell division|mesenchymal to epithelial transition|nuclear-transcribed mRNA catabolic process, non-stop decay|nonfunctional rRNA decay|nuclear-transcribed mRNA catabolic process, no-go decay|RNA surveillance|nucleic acid phosphodiester bond hydrolysis" hsa03015 mRNA surveillance pathway PELP1 1067.560106 1102.838716 1032.281497 0.936022178 -0.095385381 0.698926417 1 11.92633745 10.97651338 27043 "proline, glutamate and leucine rich protein 1" "GO:0003682,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0008134,GO:0035327,GO:0045944,GO:0071339,GO:0071391" chromatin binding|RNA binding|protein binding|nucleoplasm|nucleolus|cytoplasm|rRNA processing|transcription factor binding|transcriptionally active chromatin|positive regulation of transcription by RNA polymerase II|MLL1 complex|cellular response to estrogen stimulus PEMT 322.9660654 353.7407201 292.1914106 0.826004455 -0.275778533 0.371971454 1 11.94085521 9.698152307 10400 phosphatidylethanolamine N-methyltransferase "GO:0000773,GO:0001835,GO:0004608,GO:0005739,GO:0005783,GO:0005789,GO:0005829,GO:0006656,GO:0006686,GO:0008285,GO:0008429,GO:0016021,GO:0031526,GO:0031966,GO:0032259,GO:0033273,GO:0042383,GO:0042493,GO:0043200,GO:0043231,GO:0045471,GO:0046498,GO:0046500,GO:0050747,GO:0080101,GO:0120162" phosphatidyl-N-methylethanolamine N-methyltransferase activity|blastocyst hatching|phosphatidylethanolamine N-methyltransferase activity|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|phosphatidylcholine biosynthetic process|sphingomyelin biosynthetic process|negative regulation of cell population proliferation|phosphatidylethanolamine binding|integral component of membrane|brush border membrane|mitochondrial membrane|methylation|response to vitamin|sarcolemma|response to drug|response to amino acid|intracellular membrane-bounded organelle|response to ethanol|S-adenosylhomocysteine metabolic process|S-adenosylmethionine metabolic process|positive regulation of lipoprotein metabolic process|phosphatidyl-N-dimethylethanolamine N-methyltransferase activity|positive regulation of cold-induced thermogenesis hsa00564 Glycerophospholipid metabolism PEPD 659.2945793 641.9353656 676.653793 1.054083992 0.07598983 0.773721815 1 17.96481942 18.61955309 5184 peptidase D "GO:0004181,GO:0005515,GO:0006508,GO:0006520,GO:0008233,GO:0030145,GO:0030574,GO:0070006,GO:0070062,GO:0102009" metallocarboxypeptidase activity|protein binding|proteolysis|cellular amino acid metabolic process|peptidase activity|manganese ion binding|collagen catabolic process|metalloaminopeptidase activity|extracellular exosome|proline dipeptidase activity PER1 318.1357479 315.2454064 321.0260893 1.018337088 0.026215199 0.94338485 1 3.099496674 3.10351547 5187 period circadian regulator 1 "GO:0000122,GO:0000976,GO:0000978,GO:0001222,GO:0002028,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007623,GO:0009649,GO:0010608,GO:0019900,GO:0031490,GO:0031625,GO:0032922,GO:0042634,GO:0042752,GO:0043124,GO:0043153,GO:0043966,GO:0043967,GO:0045892,GO:0045944,GO:0046329,GO:0051591,GO:0070888,GO:0070932,GO:0097167,GO:1900015,GO:1900744,GO:2000323" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|transcription corepressor binding|regulation of sodium ion transport|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|circadian rhythm|entrainment of circadian clock|posttranscriptional regulation of gene expression|kinase binding|chromatin DNA binding|ubiquitin protein ligase binding|circadian regulation of gene expression|regulation of hair cycle|regulation of circadian rhythm|negative regulation of I-kappaB kinase/NF-kappaB signaling|entrainment of circadian clock by photoperiod|histone H3 acetylation|histone H4 acetylation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of JNK cascade|response to cAMP|E-box binding|histone H3 deacetylation|circadian regulation of translation|regulation of cytokine production involved in inflammatory response|regulation of p38MAPK cascade|negative regulation of glucocorticoid receptor signaling pathway" "hsa04710,hsa04713" Circadian rhythm|Circadian entrainment PER2 165.7289766 174.7895323 156.6684208 0.896326106 -0.157904378 0.696770515 1 1.379706565 1.215973065 8864 period circadian regulator 2 "GO:0000122,GO:0000976,GO:0001222,GO:0002931,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005978,GO:0006094,GO:0006631,GO:0007623,GO:0019229,GO:0019249,GO:0031397,GO:0032922,GO:0042752,GO:0042754,GO:0043153,GO:0045892,GO:0045893,GO:0048471,GO:0050767,GO:0050796,GO:0050872,GO:0051726,GO:0051946,GO:0070345,GO:0070932,GO:0097167,GO:0120162,GO:2000678" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|transcription corepressor binding|response to ischemia|transcription coactivator activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|glycogen biosynthetic process|gluconeogenesis|fatty acid metabolic process|circadian rhythm|regulation of vasoconstriction|lactate biosynthetic process|negative regulation of protein ubiquitination|circadian regulation of gene expression|regulation of circadian rhythm|negative regulation of circadian rhythm|entrainment of circadian clock by photoperiod|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|perinuclear region of cytoplasm|regulation of neurogenesis|regulation of insulin secretion|white fat cell differentiation|regulation of cell cycle|regulation of glutamate uptake involved in transmission of nerve impulse|negative regulation of fat cell proliferation|histone H3 deacetylation|circadian regulation of translation|positive regulation of cold-induced thermogenesis|negative regulation of transcription regulatory region DNA binding" "hsa04710,hsa04713,hsa05202,hsa05221" Circadian rhythm|Circadian entrainment|Transcriptional misregulation in cancer|Acute myeloid leukemia PER3 224.6067101 256.982229 192.2311912 0.748033014 -0.418826152 0.229322034 1 2.430816953 1.787904018 8863 period circadian regulator 3 "GO:0000122,GO:0000976,GO:0001222,GO:0005515,GO:0005634,GO:0005737,GO:0032922,GO:0043153,GO:0045187,GO:0050821" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|transcription corepressor binding|protein binding|nucleus|cytoplasm|circadian regulation of gene expression|entrainment of circadian clock by photoperiod|regulation of circadian sleep/wake cycle, sleep|protein stabilization" "hsa04710,hsa04713" Circadian rhythm|Circadian entrainment PERM1 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.030719213 0.041856243 84808 "PPARGC1 and ESRR induced regulator, muscle 1" "GO:0005634,GO:0005737,GO:0006355,GO:0014850" "nucleus|cytoplasm|regulation of transcription, DNA-templated|response to muscle activity" PERP 3587.515067 3179.504825 3995.525309 1.256650179 0.329583095 0.165308616 1 35.12405896 43.40005438 64065 p53 apoptosis effector related to PMP22 "GO:0002934,GO:0005515,GO:0005739,GO:0005794,GO:0005886,GO:0005887,GO:0005911,GO:0007219,GO:0030057,GO:0034113,GO:0042981,GO:0045862,GO:0070268,GO:0072332,GO:0097186,GO:0097202,GO:0098609" desmosome organization|protein binding|mitochondrion|Golgi apparatus|plasma membrane|integral component of plasma membrane|cell-cell junction|Notch signaling pathway|desmosome|heterotypic cell-cell adhesion|regulation of apoptotic process|positive regulation of proteolysis|cornification|intrinsic apoptotic signaling pathway by p53 class mediator|amelogenesis|activation of cysteine-type endopeptidase activity|cell-cell adhesion hsa04115 p53 signaling pathway PES1 1673.272756 1738.531598 1608.013914 0.924926482 -0.112589398 0.636928212 1 18.07211455 16.43566813 23481 pescadillo ribosomal biogenesis factor 1 "GO:0000463,GO:0000466,GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0005829,GO:0006364,GO:0008283,GO:0016020,GO:0030687,GO:0042273,GO:0043021,GO:0051726,GO:0070545" "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|cytosol|rRNA processing|cell population proliferation|membrane|preribosome, large subunit precursor|ribosomal large subunit biogenesis|ribonucleoprotein complex binding|regulation of cell cycle|PeBoW complex" PET100 201.6188395 158.1429102 245.0947688 1.5498309 0.632110814 0.081241393 1 12.72970809 19.3987586 100131801 PET100 cytochrome c oxidase chaperone "GO:0031305,GO:0033617,GO:0051082" integral component of mitochondrial inner membrane|mitochondrial cytochrome c oxidase assembly|unfolded protein binding PEX1 596.1111512 610.7229491 581.4993534 0.952149177 -0.070740471 0.793571704 1 7.397449236 6.925612183 5189 peroxisomal biogenesis factor 1 "GO:0005515,GO:0005524,GO:0005737,GO:0005777,GO:0005778,GO:0005829,GO:0006625,GO:0007031,GO:0008022,GO:0016558,GO:0016887,GO:0044877,GO:0060152,GO:0070062" protein binding|ATP binding|cytoplasm|peroxisome|peroxisomal membrane|cytosol|protein targeting to peroxisome|peroxisome organization|protein C-terminus binding|protein import into peroxisome matrix|ATPase activity|protein-containing complex binding|microtubule-based peroxisome localization|extracellular exosome hsa04146 Peroxisome PEX10 635.6670005 639.8545378 631.4794631 0.986910971 -0.01900815 0.948300298 1 10.88898619 10.56663247 5192 peroxisomal biogenesis factor 10 "GO:0005515,GO:0005777,GO:0005778,GO:0006625,GO:0007031,GO:0016558,GO:0016567,GO:0046872" protein binding|peroxisome|peroxisomal membrane|protein targeting to peroxisome|peroxisome organization|protein import into peroxisome matrix|protein ubiquitination|metal ion binding hsa04146 Peroxisome PEX11A 250.6025803 245.5376763 255.6674843 1.041255616 0.058324276 0.873369174 1 4.838956612 4.954276753 8800 peroxisomal biogenesis factor 11 alpha "GO:0005515,GO:0005777,GO:0005778,GO:0005779,GO:0007031,GO:0007165,GO:0016557,GO:0016559,GO:0019216,GO:0032991,GO:0042803,GO:0044375,GO:0050873" protein binding|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|peroxisome organization|signal transduction|peroxisome membrane biogenesis|peroxisome fission|regulation of lipid metabolic process|protein-containing complex|protein homodimerization activity|regulation of peroxisome size|brown fat cell differentiation hsa04146 Peroxisome PEX11B 575.7337618 593.0359131 558.4316104 0.941648892 -0.086738866 0.748593718 1 18.40071903 17.03707252 8799 peroxisomal biogenesis factor 11 beta "GO:0005515,GO:0005654,GO:0005739,GO:0005777,GO:0005778,GO:0005779,GO:0007031,GO:0007165,GO:0016020,GO:0016559,GO:0032991,GO:0042802,GO:0042803,GO:0043231,GO:0044375" protein binding|nucleoplasm|mitochondrion|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|peroxisome organization|signal transduction|membrane|peroxisome fission|protein-containing complex|identical protein binding|protein homodimerization activity|intracellular membrane-bounded organelle|regulation of peroxisome size hsa04146 Peroxisome PEX11G 33.54610928 35.37407201 31.71814655 0.896649573 -0.157383832 0.861265317 1 0.99203847 0.87462611 92960 peroxisomal biogenesis factor 11 gamma "GO:0005515,GO:0005777,GO:0005779,GO:0016559,GO:0031231,GO:0032991,GO:0044375" protein binding|peroxisome|integral component of peroxisomal membrane|peroxisome fission|intrinsic component of peroxisomal membrane|protein-containing complex|regulation of peroxisome size hsa04146 Peroxisome PEX12 136.7508733 133.172977 140.3287696 1.053733068 0.075509449 0.874247943 1 2.71578029 2.813820697 5193 peroxisomal biogenesis factor 12 "GO:0004842,GO:0005515,GO:0005777,GO:0005778,GO:0005779,GO:0006513,GO:0006625,GO:0007031,GO:0008022,GO:0008270,GO:0016558,GO:0016567,GO:1990429" ubiquitin-protein transferase activity|protein binding|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|protein monoubiquitination|protein targeting to peroxisome|peroxisome organization|protein C-terminus binding|zinc ion binding|protein import into peroxisome matrix|protein ubiquitination|peroxisomal importomer complex hsa04146 Peroxisome PEX13 512.8975479 495.2370081 530.5580877 1.071321567 0.099391584 0.719854127 1 5.910082495 6.225648109 5194 peroxisomal biogenesis factor 13 "GO:0001561,GO:0001764,GO:0001967,GO:0005515,GO:0005777,GO:0005778,GO:0005779,GO:0006625,GO:0007626,GO:0016020,GO:0016560,GO:0016567,GO:0021795,GO:0060152,GO:1990429" "fatty acid alpha-oxidation|neuron migration|suckling behavior|protein binding|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|protein targeting to peroxisome|locomotory behavior|membrane|protein import into peroxisome matrix, docking|protein ubiquitination|cerebral cortex cell migration|microtubule-based peroxisome localization|peroxisomal importomer complex" hsa04146 Peroxisome PEX14 602.8694254 535.8131496 669.9257013 1.250297239 0.322271114 0.220326877 1 4.754799303 5.84543238 5195 peroxisomal biogenesis factor 14 "GO:0001650,GO:0003714,GO:0005102,GO:0005515,GO:0005634,GO:0005777,GO:0005778,GO:0006625,GO:0007031,GO:0008017,GO:0016020,GO:0016021,GO:0016558,GO:0016560,GO:0016561,GO:0016567,GO:0032091,GO:0032991,GO:0034453,GO:0036250,GO:0042802,GO:0043433,GO:0044721,GO:0045892,GO:0047485,GO:0048487,GO:0065003,GO:1990429" "fibrillar center|transcription corepressor activity|signaling receptor binding|protein binding|nucleus|peroxisome|peroxisomal membrane|protein targeting to peroxisome|peroxisome organization|microtubule binding|membrane|integral component of membrane|protein import into peroxisome matrix|protein import into peroxisome matrix, docking|protein import into peroxisome matrix, translocation|protein ubiquitination|negative regulation of protein binding|protein-containing complex|microtubule anchoring|peroxisome transport along microtubule|identical protein binding|negative regulation of DNA-binding transcription factor activity|protein import into peroxisome matrix, substrate release|negative regulation of transcription, DNA-templated|protein N-terminus binding|beta-tubulin binding|protein-containing complex assembly|peroxisomal importomer complex" hsa04146 Peroxisome PEX16 649.9358848 610.7229491 689.1488204 1.12841481 0.174297506 0.503740103 1 19.54026459 21.68055503 9409 peroxisomal biogenesis factor 16 "GO:0005515,GO:0005777,GO:0005778,GO:0005779,GO:0005783,GO:0005789,GO:0006625,GO:0007031,GO:0008022,GO:0016020,GO:0016557,GO:0016558,GO:0022615,GO:0032581,GO:0045046,GO:0106101" protein binding|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|protein targeting to peroxisome|peroxisome organization|protein C-terminus binding|membrane|peroxisome membrane biogenesis|protein import into peroxisome matrix|protein to membrane docking|ER-dependent peroxisome organization|protein import into peroxisome membrane|ER-dependent peroxisome localization hsa04146 Peroxisome PEX19 2353.47745 1970.543894 2736.411007 1.388657728 0.473691052 0.045262469 1 28.64731842 39.11563359 5824 peroxisomal biogenesis factor 19 "GO:0005515,GO:0005654,GO:0005737,GO:0005777,GO:0005778,GO:0005829,GO:0006625,GO:0007031,GO:0016559,GO:0031526,GO:0032991,GO:0033328,GO:0036105,GO:0045046,GO:0047485,GO:0050821,GO:0051117,GO:0055085,GO:0061077,GO:0072321,GO:0072663,GO:1900131" protein binding|nucleoplasm|cytoplasm|peroxisome|peroxisomal membrane|cytosol|protein targeting to peroxisome|peroxisome organization|peroxisome fission|brush border membrane|protein-containing complex|peroxisome membrane targeting sequence binding|peroxisome membrane class-1 targeting sequence binding|protein import into peroxisome membrane|protein N-terminus binding|protein stabilization|ATPase binding|transmembrane transport|chaperone-mediated protein folding|chaperone-mediated protein transport|establishment of protein localization to peroxisome|negative regulation of lipid binding hsa04146 Peroxisome PEX2 1120.760837 1061.22216 1180.299514 1.112207753 0.153426299 0.530039506 1 13.07676662 14.30070572 5828 peroxisomal biogenesis factor 2 "GO:0000038,GO:0000122,GO:0005515,GO:0005778,GO:0005779,GO:0006625,GO:0006635,GO:0007031,GO:0016020,GO:0016558,GO:0016567,GO:0016593,GO:0031648,GO:0046872,GO:0048147,GO:0050680" very long-chain fatty acid metabolic process|negative regulation of transcription by RNA polymerase II|protein binding|peroxisomal membrane|integral component of peroxisomal membrane|protein targeting to peroxisome|fatty acid beta-oxidation|peroxisome organization|membrane|protein import into peroxisome matrix|protein ubiquitination|Cdc73/Paf1 complex|protein destabilization|metal ion binding|negative regulation of fibroblast proliferation|negative regulation of epithelial cell proliferation hsa04146 Peroxisome PEX26 1469.802031 1405.599155 1534.004906 1.091353036 0.126117867 0.598954578 1 4.081741405 4.380078827 55670 peroxisomal biogenesis factor 26 "GO:0005515,GO:0005777,GO:0005778,GO:0005779,GO:0006625,GO:0008022,GO:0016558,GO:0044877,GO:0045046,GO:0051117" protein binding|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|protein targeting to peroxisome|protein C-terminus binding|protein import into peroxisome matrix|protein-containing complex binding|protein import into peroxisome membrane|ATPase binding hsa04146 Peroxisome PEX3 406.2891091 396.3976893 416.1805289 1.049906546 0.070260917 0.814880375 1 7.692733138 7.941499066 8504 peroxisomal biogenesis factor 3 "GO:0005515,GO:0005654,GO:0005777,GO:0005778,GO:0005779,GO:0005783,GO:0005829,GO:0007031,GO:0008289,GO:0016020,GO:0016557,GO:0030674,GO:0032991,GO:0032994,GO:0045046,GO:0055085" protein binding|nucleoplasm|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|endoplasmic reticulum|cytosol|peroxisome organization|lipid binding|membrane|peroxisome membrane biogenesis|protein-macromolecule adaptor activity|protein-containing complex|protein-lipid complex|protein import into peroxisome membrane|transmembrane transport hsa04146 Peroxisome PEX5 914.8658713 980.0698774 849.6618651 0.866940087 -0.2059958 0.406985324 1 10.51136014 8.96023046 5830 peroxisomal biogenesis factor 5 "GO:0000268,GO:0005052,GO:0005515,GO:0005737,GO:0005777,GO:0005778,GO:0005794,GO:0005829,GO:0006625,GO:0016020,GO:0016558,GO:0016560,GO:0016567,GO:0019899,GO:0031267,GO:0031333,GO:0032991,GO:0033328,GO:0045046,GO:0047485,GO:0140311" "peroxisome targeting sequence binding|peroxisome matrix targeting signal-1 binding|protein binding|cytoplasm|peroxisome|peroxisomal membrane|Golgi apparatus|cytosol|protein targeting to peroxisome|membrane|protein import into peroxisome matrix|protein import into peroxisome matrix, docking|protein ubiquitination|enzyme binding|small GTPase binding|negative regulation of protein-containing complex assembly|protein-containing complex|peroxisome membrane targeting sequence binding|protein import into peroxisome membrane|protein N-terminus binding|protein sequestering activity" hsa04146 Peroxisome PEX5L 4.92466667 3.121241648 6.728091692 2.155581801 1.108077311 0.568402303 1 0.013659281 0.028950997 51555 peroxisomal biogenesis factor 5 like "GO:0000268,GO:0005052,GO:0005778,GO:0005829,GO:0016560,GO:0031267,GO:0043235,GO:0043949" "peroxisome targeting sequence binding|peroxisome matrix targeting signal-1 binding|peroxisomal membrane|cytosol|protein import into peroxisome matrix, docking|small GTPase binding|receptor complex|regulation of cAMP-mediated signaling" hsa04146 Peroxisome PEX6 113.009438 115.485941 110.5329349 0.95711161 -0.063240925 0.907956141 1 1.376959878 1.295850943 5190 peroxisomal biogenesis factor 6 "GO:0001750,GO:0005515,GO:0005524,GO:0005737,GO:0005777,GO:0005778,GO:0005829,GO:0006625,GO:0007031,GO:0008022,GO:0016558,GO:0016561,GO:0016887,GO:0044877,GO:0050821,GO:0097733" "photoreceptor outer segment|protein binding|ATP binding|cytoplasm|peroxisome|peroxisomal membrane|cytosol|protein targeting to peroxisome|peroxisome organization|protein C-terminus binding|protein import into peroxisome matrix|protein import into peroxisome matrix, translocation|ATPase activity|protein-containing complex binding|protein stabilization|photoreceptor cell cilium" hsa04146 Peroxisome PEX7 120.9068913 95.7180772 146.0957053 1.526312579 0.610050447 0.164411442 1 1.776799255 2.666570226 5191 peroxisomal biogenesis factor 7 "GO:0001764,GO:0001958,GO:0005053,GO:0005515,GO:0005777,GO:0005778,GO:0005782,GO:0005829,GO:0006625,GO:0006635,GO:0007031,GO:0008611,GO:0016558,GO:0019899,GO:0042803" neuron migration|endochondral ossification|peroxisome matrix targeting signal-2 binding|protein binding|peroxisome|peroxisomal membrane|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid beta-oxidation|peroxisome organization|ether lipid biosynthetic process|protein import into peroxisome matrix|enzyme binding|protein homodimerization activity hsa04146 Peroxisome PFAS 921.9795774 1116.364096 727.5950587 0.651754263 -0.617599981 0.012742242 0.667587345 10.12547587 6.488891346 5198 phosphoribosylformylglycinamidine synthase "GO:0004642,GO:0005524,GO:0005829,GO:0006189,GO:0006541,GO:0009168,GO:0042493,GO:0046872,GO:0070062,GO:0097065" phosphoribosylformylglycinamidine synthase activity|ATP binding|cytosol|'de novo' IMP biosynthetic process|glutamine metabolic process|purine ribonucleoside monophosphate biosynthetic process|response to drug|metal ion binding|extracellular exosome|anterior head development hsa00230 Purine metabolism PFDN1 1627.986413 1420.16495 1835.807876 1.292672289 0.370356577 0.119475339 1 38.90738872 49.45289282 5201 prefoldin subunit 1 "GO:0001540,GO:0005515,GO:0005737,GO:0006457,GO:0016272,GO:0044183,GO:0051082,GO:1905907" amyloid-beta binding|protein binding|cytoplasm|protein folding|prefoldin complex|protein folding chaperone|unfolded protein binding|negative regulation of amyloid fibril formation PFDN2 1070.746743 946.7766332 1194.716853 1.261878263 0.335572736 0.169759433 1 77.49651658 96.15476694 5202 prefoldin subunit 2 "GO:0001540,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006457,GO:0016272,GO:0044183,GO:0051082,GO:0051495,GO:1905907" amyloid-beta binding|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|protein folding|prefoldin complex|protein folding chaperone|unfolded protein binding|positive regulation of cytoskeleton organization|negative regulation of amyloid fibril formation PFDN4 696.7299718 665.8648849 727.5950587 1.092706757 0.127906285 0.621108747 1 25.97659729 27.90982213 5203 prefoldin subunit 4 "GO:0001540,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006457,GO:0016272,GO:0051082,GO:0051087,GO:1905907" amyloid-beta binding|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|protein folding|prefoldin complex|unfolded protein binding|chaperone binding|negative regulation of amyloid fibril formation PFDN5 3266.644306 2893.391008 3639.897605 1.25800405 0.331136567 0.162531702 1 259.0855038 320.4766056 5204 prefoldin subunit 5 "GO:0001540,GO:0003714,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006355,GO:0006457,GO:0016272,GO:0045111,GO:0045892,GO:0051082,GO:0090090,GO:1905907" "amyloid-beta binding|transcription corepressor activity|protein binding|nucleus|cytoplasm|cytosol|regulation of transcription, DNA-templated|protein folding|prefoldin complex|intermediate filament cytoskeleton|negative regulation of transcription, DNA-templated|unfolded protein binding|negative regulation of canonical Wnt signaling pathway|negative regulation of amyloid fibril formation" PFDN6 455.37726 423.4484502 487.3060697 1.150803762 0.202641843 0.471351501 1 37.8537111 42.83323884 10471 prefoldin subunit 6 "GO:0001540,GO:0005515,GO:0005737,GO:0006457,GO:0016272,GO:0051082,GO:0051087,GO:0051131,GO:1905907" amyloid-beta binding|protein binding|cytoplasm|protein folding|prefoldin complex|unfolded protein binding|chaperone binding|chaperone-mediated protein complex assembly|negative regulation of amyloid fibril formation PFKFB1 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.039148045 0.059267653 5207 "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1" "GO:0003873,GO:0004331,GO:0005515,GO:0005524,GO:0005829,GO:0006000,GO:0006003,GO:0006094,GO:0006096,GO:0016311,GO:0019900,GO:0031100,GO:0032868,GO:0033133,GO:0033762,GO:0042594,GO:0042802,GO:0043540,GO:0045820,GO:0045821,GO:0046835,GO:0051384,GO:0051591,GO:0070095" "6-phosphofructo-2-kinase activity|fructose-2,6-bisphosphate 2-phosphatase activity|protein binding|ATP binding|cytosol|fructose metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolytic process|dephosphorylation|kinase binding|animal organ regeneration|response to insulin|positive regulation of glucokinase activity|response to glucagon|response to starvation|identical protein binding|6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex|negative regulation of glycolytic process|positive regulation of glycolytic process|carbohydrate phosphorylation|response to glucocorticoid|response to cAMP|fructose-6-phosphate binding" "hsa00051,hsa04152,hsa04922" Fructose and mannose metabolism|AMPK signaling pathway|Glucagon signaling pathway PFKFB2 457.0511229 543.0960467 371.006199 0.683131835 -0.549764069 0.048857135 1 2.477903552 1.664409176 5208 "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2" "GO:0003873,GO:0004331,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006000,GO:0006003,GO:0006007,GO:0006089,GO:0006096,GO:0009749,GO:0016311,GO:0019901,GO:0032024,GO:0033133,GO:0045821,GO:0046835" "6-phosphofructo-2-kinase activity|fructose-2,6-bisphosphate 2-phosphatase activity|protein binding|ATP binding|nucleoplasm|cytosol|fructose metabolic process|fructose 2,6-bisphosphate metabolic process|glucose catabolic process|lactate metabolic process|glycolytic process|response to glucose|dephosphorylation|protein kinase binding|positive regulation of insulin secretion|positive regulation of glucokinase activity|positive regulation of glycolytic process|carbohydrate phosphorylation" "hsa00051,hsa04152,hsa04919" Fructose and mannose metabolism|AMPK signaling pathway|Thyroid hormone signaling pathway PFKFB3 1130.659246 1144.455271 1116.863221 0.97589067 -0.035208565 0.888495735 1 11.90826173 11.42669711 5209 "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3" "GO:0003873,GO:0004331,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006000,GO:0006003,GO:0016311,GO:0045821,GO:0046835" "6-phosphofructo-2-kinase activity|fructose-2,6-bisphosphate 2-phosphatase activity|protein binding|ATP binding|nucleoplasm|cytosol|fructose metabolic process|fructose 2,6-bisphosphate metabolic process|dephosphorylation|positive regulation of glycolytic process|carbohydrate phosphorylation" "hsa00051,hsa04066,hsa04152" Fructose and mannose metabolism|HIF-1 signaling pathway|AMPK signaling pathway PFKFB4 430.129924 366.2256867 494.0341614 1.348988286 0.431877821 0.12794081 1 3.428910843 4.548158069 5210 "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4" "GO:0003873,GO:0004331,GO:0005515,GO:0005524,GO:0005829,GO:0006000,GO:0006003,GO:0016311,GO:0045821,GO:0046835" "6-phosphofructo-2-kinase activity|fructose-2,6-bisphosphate 2-phosphatase activity|protein binding|ATP binding|cytosol|fructose metabolic process|fructose 2,6-bisphosphate metabolic process|dephosphorylation|positive regulation of glycolytic process|carbohydrate phosphorylation" "hsa00051,hsa04152" Fructose and mannose metabolism|AMPK signaling pathway PFKL 2441.917046 2235.849434 2647.984659 1.184330491 0.244071726 0.301942429 1 29.57203841 34.43700319 5211 "phosphofructokinase, liver type" "GO:0003872,GO:0005515,GO:0005524,GO:0005576,GO:0005829,GO:0005945,GO:0006002,GO:0006096,GO:0009749,GO:0016020,GO:0016208,GO:0019900,GO:0030388,GO:0034774,GO:0042802,GO:0043312,GO:0046676,GO:0046872,GO:0048029,GO:0061621,GO:0070061,GO:0070062,GO:0070095,GO:1904813" "6-phosphofructokinase activity|protein binding|ATP binding|extracellular region|cytosol|6-phosphofructokinase complex|fructose 6-phosphate metabolic process|glycolytic process|response to glucose|membrane|AMP binding|kinase binding|fructose 1,6-bisphosphate metabolic process|secretory granule lumen|identical protein binding|neutrophil degranulation|negative regulation of insulin secretion|metal ion binding|monosaccharide binding|canonical glycolysis|fructose binding|extracellular exosome|fructose-6-phosphate binding|ficolin-1-rich granule lumen" "hsa00010,hsa00030,hsa00051,hsa00052,hsa03018,hsa04066,hsa04152,hsa04919,hsa04922,hsa05230" Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|Galactose metabolism|RNA degradation|HIF-1 signaling pathway|AMPK signaling pathway|Thyroid hormone signaling pathway|Glucagon signaling pathway|Central carbon metabolism in cancer PFKM 2701.214075 2570.862704 2831.565446 1.101406715 0.13934731 0.556271337 1 27.61163563 29.90274328 5213 "phosphofructokinase, muscle" "GO:0003872,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0005945,GO:0006002,GO:0006096,GO:0008022,GO:0016020,GO:0016208,GO:0016324,GO:0019900,GO:0030388,GO:0042802,GO:0045944,GO:0046716,GO:0046872,GO:0048029,GO:0061615,GO:0061621,GO:0070061,GO:0070095" "6-phosphofructokinase activity|protein binding|ATP binding|nucleus|cytosol|6-phosphofructokinase complex|fructose 6-phosphate metabolic process|glycolytic process|protein C-terminus binding|membrane|AMP binding|apical plasma membrane|kinase binding|fructose 1,6-bisphosphate metabolic process|identical protein binding|positive regulation of transcription by RNA polymerase II|muscle cell cellular homeostasis|metal ion binding|monosaccharide binding|glycolytic process through fructose-6-phosphate|canonical glycolysis|fructose binding|fructose-6-phosphate binding" "hsa00010,hsa00030,hsa00051,hsa00052,hsa03018,hsa04066,hsa04152,hsa04919,hsa04922,hsa05230" Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|Galactose metabolism|RNA degradation|HIF-1 signaling pathway|AMPK signaling pathway|Thyroid hormone signaling pathway|Glucagon signaling pathway|Central carbon metabolism in cancer PFKP 6770.31931 6319.473923 7221.164697 1.142684468 0.192427084 0.430193253 1 93.19113252 104.7061262 5214 "phosphofructokinase, platelet" "GO:0003872,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005945,GO:0006002,GO:0016020,GO:0016208,GO:0030388,GO:0042802,GO:0044877,GO:0045296,GO:0046872,GO:0048029,GO:0061621,GO:0070062,GO:0070095,GO:1990830" "6-phosphofructokinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|6-phosphofructokinase complex|fructose 6-phosphate metabolic process|membrane|AMP binding|fructose 1,6-bisphosphate metabolic process|identical protein binding|protein-containing complex binding|cadherin binding|metal ion binding|monosaccharide binding|canonical glycolysis|extracellular exosome|fructose-6-phosphate binding|cellular response to leukemia inhibitory factor" "hsa00010,hsa00030,hsa00051,hsa00052,hsa03018,hsa04066,hsa04152,hsa04919,hsa04922,hsa05230" Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|Galactose metabolism|RNA degradation|HIF-1 signaling pathway|AMPK signaling pathway|Thyroid hormone signaling pathway|Glucagon signaling pathway|Central carbon metabolism in cancer PFN1 17256.44789 15868.39254 18644.50323 1.17494593 0.232594367 0.384567853 1 589.3298155 680.8437789 5216 profilin 1 "GO:0000774,GO:0001784,GO:0003723,GO:0003779,GO:0003785,GO:0005515,GO:0005546,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005925,GO:0005938,GO:0010634,GO:0016020,GO:0030036,GO:0030833,GO:0030837,GO:0030838,GO:0032232,GO:0032233,GO:0032781,GO:0045296,GO:0050821,GO:0051497,GO:0060071,GO:0070062,GO:0070064,GO:0072562,GO:1900029" "adenyl-nucleotide exchange factor activity|phosphotyrosine residue binding|RNA binding|actin binding|actin monomer binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|nucleus|cytoplasm|cytosol|cytoskeleton|focal adhesion|cell cortex|positive regulation of epithelial cell migration|membrane|actin cytoskeleton organization|regulation of actin filament polymerization|negative regulation of actin filament polymerization|positive regulation of actin filament polymerization|negative regulation of actin filament bundle assembly|positive regulation of actin filament bundle assembly|positive regulation of ATPase activity|cadherin binding|protein stabilization|negative regulation of stress fiber assembly|Wnt signaling pathway, planar cell polarity pathway|extracellular exosome|proline-rich region binding|blood microparticle|positive regulation of ruffle assembly" "hsa04015,hsa04810,hsa05014,hsa05131,hsa05132" Rap1 signaling pathway|Regulation of actin cytoskeleton|Amyotrophic lateral sclerosis|Shigellosis|Salmonella infection PFN2 5827.807629 5370.616462 6284.998796 1.170256495 0.226824772 0.348274122 1 140.0195065 161.1167828 5217 profilin 2 "GO:0003779,GO:0003785,GO:0005515,GO:0005546,GO:0005737,GO:0005856,GO:0010633,GO:0016887,GO:0030036,GO:0030833,GO:0030837,GO:0030838,GO:0032233,GO:0032781,GO:0033138,GO:0050821,GO:0051496,GO:0070062,GO:1900028" "actin binding|actin monomer binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|cytoskeleton|negative regulation of epithelial cell migration|ATPase activity|actin cytoskeleton organization|regulation of actin filament polymerization|negative regulation of actin filament polymerization|positive regulation of actin filament polymerization|positive regulation of actin filament bundle assembly|positive regulation of ATPase activity|positive regulation of peptidyl-serine phosphorylation|protein stabilization|positive regulation of stress fiber assembly|extracellular exosome|negative regulation of ruffle assembly" "hsa04015,hsa04810,hsa05014,hsa05131,hsa05132" Rap1 signaling pathway|Regulation of actin cytoskeleton|Amyotrophic lateral sclerosis|Shigellosis|Salmonella infection PFN4 14.16950472 18.72744989 9.61155956 0.513233762 -0.962312016 0.340500071 1 0.407273668 0.20552882 375189 profilin family member 4 "GO:0003785,GO:0005856,GO:0005938,GO:0008289,GO:0042989" actin monomer binding|cytoskeleton|cell cortex|lipid binding|sequestering of actin monomers "hsa04015,hsa04810,hsa05014,hsa05131,hsa05132" Rap1 signaling pathway|Regulation of actin cytoskeleton|Amyotrophic lateral sclerosis|Shigellosis|Salmonella infection PGAM1 15742.2916 13222.62003 18261.96316 1.381115325 0.465833791 0.07833439 1 368.8797329 500.9402378 5223 phosphoglycerate mutase 1 "GO:0004082,GO:0004619,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0006094,GO:0006096,GO:0006110,GO:0016020,GO:0016787,GO:0019901,GO:0034774,GO:0043312,GO:0043456,GO:0045730,GO:0061621,GO:0070062,GO:1904813" bisphosphoglycerate mutase activity|phosphoglycerate mutase activity|protein binding|extracellular region|cytoplasm|cytosol|gluconeogenesis|glycolytic process|regulation of glycolytic process|membrane|hydrolase activity|protein kinase binding|secretory granule lumen|neutrophil degranulation|regulation of pentose-phosphate shunt|respiratory burst|canonical glycolysis|extracellular exosome|ficolin-1-rich granule lumen "hsa00010,hsa00260,hsa04922,hsa05230" "Glycolysis / Gluconeogenesis|Glycine, serine and threonine metabolism|Glucagon signaling pathway|Central carbon metabolism in cancer" PGAM4 45.03532137 46.81862472 43.25201802 0.923820772 -0.11431511 0.889553125 1 1.478475711 1.34299098 441531 phosphoglycerate mutase family member 4 "GO:0004082,GO:0004619,GO:0006096,GO:0016787,GO:0070062,GO:0097228,GO:1902093" bisphosphoglycerate mutase activity|phosphoglycerate mutase activity|glycolytic process|hydrolase activity|extracellular exosome|sperm principal piece|positive regulation of flagellated sperm motility "hsa00010,hsa00260,hsa04922,hsa05230" "Glycolysis / Gluconeogenesis|Glycine, serine and threonine metabolism|Glucagon signaling pathway|Central carbon metabolism in cancer" PGAM5 903.2181433 964.4636692 841.9726175 0.872995681 -0.195953579 0.431018601 1 15.99989227 13.73410401 192111 "PGAM family member 5, mitochondrial serine/threonine protein phosphatase" "GO:0004722,GO:0005096,GO:0005515,GO:0005739,GO:0005741,GO:0006470,GO:0016021,GO:0016236,GO:0016791,GO:0043547,GO:0044877,GO:0070266,GO:0106306,GO:0106307,GO:0120163" protein serine/threonine phosphatase activity|GTPase activator activity|protein binding|mitochondrion|mitochondrial outer membrane|protein dephosphorylation|integral component of membrane|macroautophagy|phosphatase activity|positive regulation of GTPase activity|protein-containing complex binding|necroptotic process|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of cold-induced thermogenesis "hsa04137,hsa04217,hsa04668" Mitophagy - animal|Necroptosis|TNF signaling pathway PGAP1 714.0502863 716.8451651 711.2554074 0.99220228 -0.011293822 0.970830509 1 3.239897439 3.160841086 80055 post-GPI attachment to proteins inositol deacylase 1 "GO:0005783,GO:0005789,GO:0006505,GO:0006888,GO:0007605,GO:0009880,GO:0009948,GO:0015031,GO:0016021,GO:0016255,GO:0016788,GO:0021871,GO:0050185,GO:1902953" "endoplasmic reticulum|endoplasmic reticulum membrane|GPI anchor metabolic process|endoplasmic reticulum to Golgi vesicle-mediated transport|sensory perception of sound|embryonic pattern specification|anterior/posterior axis specification|protein transport|integral component of membrane|attachment of GPI anchor to protein|hydrolase activity, acting on ester bonds|forebrain regionalization|phosphatidylinositol deacylase activity|positive regulation of ER to Golgi vesicle-mediated transport" hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PGAP2 296.8513083 362.0640312 231.6385854 0.639772431 -0.64436927 0.04106676 1 4.815024146 3.028971378 27315 post-GPI attachment to proteins 2 "GO:0000139,GO:0005515,GO:0005789,GO:0006506,GO:0016021" Golgi membrane|protein binding|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane PGAP3 132.9358176 159.183324 106.6883111 0.670222913 -0.577287086 0.17321619 1 3.002941477 1.978961376 93210 post-GPI attachment to proteins phospholipase 3 "GO:0000139,GO:0005515,GO:0006505,GO:0006506,GO:0016021,GO:0016788,GO:0031227" "Golgi membrane|protein binding|GPI anchor metabolic process|GPI anchor biosynthetic process|integral component of membrane|hydrolase activity, acting on ester bonds|intrinsic component of endoplasmic reticulum membrane" PGAP4 596.5470698 622.1675018 570.9266379 0.917641369 -0.123997663 0.64144719 1 6.939171594 6.261116569 84302 post-GPI attachment to proteins GalNAc transferase 4 "GO:0000139,GO:0006506,GO:0016021,GO:0016757" "Golgi membrane|GPI anchor biosynthetic process|integral component of membrane|transferase activity, transferring glycosyl groups" PGAP6 1200.744373 1142.374443 1259.114302 1.102190538 0.140373648 0.563626886 1 16.4197211 17.79482138 58986 post-glycosylphosphatidylinositol attachment to proteins 6 "GO:0003674,GO:0004623,GO:0005515,GO:0005765,GO:0005886,GO:0005887,GO:0008150,GO:0070062,GO:0102567,GO:0102568" "molecular_function|phospholipase A2 activity|protein binding|lysosomal membrane|plasma membrane|integral component of plasma membrane|biological_process|extracellular exosome|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)" PGBD1 313.8948344 304.8412676 322.9484012 1.059398564 0.083245458 0.79738351 1 3.808243956 3.966937152 84547 piggyBac transposable element derived 1 "GO:0000978,GO:0000981,GO:0005044,GO:0005515,GO:0006357,GO:0006897,GO:0016020,GO:0042802" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|scavenger receptor activity|protein binding|regulation of transcription by RNA polymerase II|endocytosis|membrane|identical protein binding" PGBD2 86.94437067 99.87973273 74.00900861 0.740981244 -0.43249107 0.383847558 1 1.77384285 1.292389841 267002 piggyBac transposable element derived 2 GO:0043565 sequence-specific DNA binding PGBD4 91.43814916 79.07145508 103.8048432 1.312797939 0.392644879 0.422811207 1 0.638991252 0.824829106 161779 piggyBac transposable element derived 4 PGD 4438.593131 4932.602218 3944.584043 0.799696361 -0.322475772 0.177235303 1 116.0687454 91.26654046 5226 phosphogluconate dehydrogenase "GO:0004616,GO:0005634,GO:0005829,GO:0006098,GO:0009051,GO:0019322,GO:0046177,GO:0050661,GO:0055114,GO:0070062" "phosphogluconate dehydrogenase (decarboxylating) activity|nucleus|cytosol|pentose-phosphate shunt|pentose-phosphate shunt, oxidative branch|pentose biosynthetic process|D-gluconate catabolic process|NADP binding|oxidation-reduction process|extracellular exosome" "hsa00030,hsa00480" Pentose phosphate pathway|Glutathione metabolism PGF 212.4092071 214.3252598 210.4931544 0.982120141 -0.026028577 0.956061336 1 6.558569498 6.333516713 5228 placental growth factor "GO:0001666,GO:0001934,GO:0001938,GO:0002040,GO:0005172,GO:0005515,GO:0005576,GO:0005615,GO:0007165,GO:0007267,GO:0008083,GO:0008201,GO:0008284,GO:0016020,GO:0030154,GO:0038084,GO:0042056,GO:0045766,GO:0048010,GO:0050918,GO:0050930,GO:0051781,GO:0060754" response to hypoxia|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|sprouting angiogenesis|vascular endothelial growth factor receptor binding|protein binding|extracellular region|extracellular space|signal transduction|cell-cell signaling|growth factor activity|heparin binding|positive regulation of cell population proliferation|membrane|cell differentiation|vascular endothelial growth factor signaling pathway|chemoattractant activity|positive regulation of angiogenesis|vascular endothelial growth factor receptor signaling pathway|positive chemotaxis|induction of positive chemotaxis|positive regulation of cell division|positive regulation of mast cell chemotaxis "hsa04010,hsa04014,hsa04015,hsa04151,hsa04510,hsa05200" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Pathways in cancer PGGHG 532.496835 555.5810133 509.4126567 0.916900766 -0.125162492 0.646553442 1 6.033849729 5.439863523 80162 protein-glucosylgalactosylhydroxylysine glucosidase "GO:0004553,GO:0005829,GO:0005975,GO:0018215,GO:0047402" "hydrolase activity, hydrolyzing O-glycosyl compounds|cytosol|carbohydrate metabolic process|protein phosphopantetheinylation|protein-glucosylgalactosylhydroxylysine glucosidase activity" PGGT1B 615.4827254 639.8545378 591.1109129 0.923820772 -0.11431511 0.666242423 1 2.563845685 2.328899692 5229 protein geranylgeranyltransferase type I subunit beta "GO:0004661,GO:0004662,GO:0005515,GO:0005953,GO:0008144,GO:0008270,GO:0008284,GO:0018215,GO:0018342,GO:0018344,GO:0019840,GO:0034097,GO:0042277,GO:0045787,GO:0051771" protein geranylgeranyltransferase activity|CAAX-protein geranylgeranyltransferase activity|protein binding|CAAX-protein geranylgeranyltransferase complex|drug binding|zinc ion binding|positive regulation of cell population proliferation|protein phosphopantetheinylation|protein prenylation|protein geranylgeranylation|isoprenoid binding|response to cytokine|peptide binding|positive regulation of cell cycle|negative regulation of nitric-oxide synthase biosynthetic process PGK1 22185.17795 18049.10004 26321.25585 1.458314032 0.544301422 0.050482387 1 200.1760798 287.0347072 5230 phosphoglycerate kinase 1 "GO:0004618,GO:0005515,GO:0005524,GO:0005615,GO:0005829,GO:0006094,GO:0006096,GO:0016020,GO:0016310,GO:0016525,GO:0030855,GO:0031639,GO:0043531,GO:0045121,GO:0047134,GO:0061621,GO:0070062,GO:0071456" phosphoglycerate kinase activity|protein binding|ATP binding|extracellular space|cytosol|gluconeogenesis|glycolytic process|membrane|phosphorylation|negative regulation of angiogenesis|epithelial cell differentiation|plasminogen activation|ADP binding|membrane raft|protein-disulfide reductase activity|canonical glycolysis|extracellular exosome|cellular response to hypoxia "hsa00010,hsa04066" Glycolysis / Gluconeogenesis|HIF-1 signaling pathway PGLS 521.3347155 527.4898385 515.1795924 0.976662591 -0.034067856 0.907098446 1 14.41431807 13.84235022 25796 6-phosphogluconolactonase "GO:0005515,GO:0005737,GO:0005829,GO:0005975,GO:0006098,GO:0009051,GO:0017057,GO:0070062" "protein binding|cytoplasm|cytosol|carbohydrate metabolic process|pentose-phosphate shunt|pentose-phosphate shunt, oxidative branch|6-phosphogluconolactonase activity|extracellular exosome" hsa00030 Pentose phosphate pathway PGM1 2254.287845 2344.052478 2164.523213 0.923410731 -0.114955596 0.62766371 1 38.8743855 35.29633666 5236 phosphoglucomutase 1 "GO:0000287,GO:0004614,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0005975,GO:0005978,GO:0005980,GO:0006006,GO:0006094,GO:0006096,GO:0019388,GO:0043312,GO:0070062,GO:1904724,GO:1904813" magnesium ion binding|phosphoglucomutase activity|protein binding|extracellular region|cytoplasm|cytosol|carbohydrate metabolic process|glycogen biosynthetic process|glycogen catabolic process|glucose metabolic process|gluconeogenesis|glycolytic process|galactose catabolic process|neutrophil degranulation|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen "hsa00010,hsa00030,hsa00052,hsa00230,hsa00500,hsa00520" Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Galactose metabolism|Purine metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism PGM2 1870.607252 1695.874629 2045.339874 1.206067854 0.270311076 0.253963005 1 26.79269155 31.77307625 55276 phosphoglucomutase 2 "GO:0000287,GO:0004614,GO:0005515,GO:0005576,GO:0005829,GO:0005978,GO:0005980,GO:0006006,GO:0006098,GO:0008973,GO:0019388,GO:0034774,GO:0043312,GO:0046386,GO:0070062,GO:1904813" magnesium ion binding|phosphoglucomutase activity|protein binding|extracellular region|cytosol|glycogen biosynthetic process|glycogen catabolic process|glucose metabolic process|pentose-phosphate shunt|phosphopentomutase activity|galactose catabolic process|secretory granule lumen|neutrophil degranulation|deoxyribose phosphate catabolic process|extracellular exosome|ficolin-1-rich granule lumen "hsa00010,hsa00030,hsa00052,hsa00230,hsa00500,hsa00520" Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Galactose metabolism|Purine metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism PGM2L1 532.45279 466.1054194 598.8001606 1.284688261 0.361418321 0.180063336 1 2.912785664 3.679403885 283209 phosphoglucomutase 2 like 1 "GO:0005829,GO:0005978,GO:0005980,GO:0016868,GO:0019388,GO:0046872,GO:0047933,GO:0061621" "cytosol|glycogen biosynthetic process|glycogen catabolic process|intramolecular transferase activity, phosphotransferases|galactose catabolic process|metal ion binding|glucose-1,6-bisphosphate synthase activity|canonical glycolysis" hsa00500 Starch and sucrose metabolism PGM3 1531.171973 1464.902747 1597.441199 1.090475939 0.124957938 0.601562917 1 12.41333236 13.30992627 5238 phosphoglucomutase 3 "GO:0000287,GO:0004610,GO:0004614,GO:0005575,GO:0005829,GO:0005975,GO:0006041,GO:0006048,GO:0006487,GO:0006493,GO:0007283,GO:0019255,GO:0030097" magnesium ion binding|phosphoacetylglucosamine mutase activity|phosphoglucomutase activity|cellular_component|cytosol|carbohydrate metabolic process|glucosamine metabolic process|UDP-N-acetylglucosamine biosynthetic process|protein N-linked glycosylation|protein O-linked glycosylation|spermatogenesis|glucose 1-phosphate metabolic process|hemopoiesis hsa00520 Amino sugar and nucleotide sugar metabolism PGM5 12.33148116 8.323311061 16.33965125 1.96311914 0.973147731 0.371650685 1 0.063339486 0.122262246 5239 phosphoglucomutase 5 "GO:0000287,GO:0001725,GO:0004614,GO:0005198,GO:0005829,GO:0005912,GO:0005914,GO:0005925,GO:0005975,GO:0006006,GO:0007155,GO:0009898,GO:0014704,GO:0014706,GO:0016010,GO:0030018,GO:0030055,GO:0030239,GO:0042383,GO:0043034" magnesium ion binding|stress fiber|phosphoglucomutase activity|structural molecule activity|cytosol|adherens junction|spot adherens junction|focal adhesion|carbohydrate metabolic process|glucose metabolic process|cell adhesion|cytoplasmic side of plasma membrane|intercalated disc|striated muscle tissue development|dystrophin-associated glycoprotein complex|Z disc|cell-substrate junction|myofibril assembly|sarcolemma|costamere PGP 495.5225132 480.6712138 510.3738126 1.061794004 0.086503899 0.758041514 1 8.107629344 8.464578421 283871 phosphoglycolate phosphatase "GO:0000121,GO:0000287,GO:0004725,GO:0005737,GO:0006114,GO:0006650,GO:0008967,GO:0016311,GO:0016791,GO:0035335,GO:0043136,GO:0045721,GO:0098519" "glycerol-1-phosphatase activity|magnesium ion binding|protein tyrosine phosphatase activity|cytoplasm|glycerol biosynthetic process|glycerophospholipid metabolic process|phosphoglycolate phosphatase activity|dephosphorylation|phosphatase activity|peptidyl-tyrosine dephosphorylation|glycerol-3-phosphatase activity|negative regulation of gluconeogenesis|nucleotide phosphatase activity, acting on free nucleotides" hsa00630 Glyoxylate and dicarboxylate metabolism PGPEP1 492.3465513 510.8432164 473.8498863 0.927583789 -0.108450488 0.697713941 1 3.785443428 3.452558841 54858 pyroglutamyl-peptidase I "GO:0005829,GO:0006508,GO:0016920" cytosol|proteolysis|pyroglutamyl-peptidase activity PGRMC1 2327.32245 2078.746938 2575.897962 1.239158993 0.309361308 0.190676398 1 59.04146007 71.93749331 10857 progesterone receptor membrane component 1 "GO:0001540,GO:0005496,GO:0005515,GO:0005741,GO:0005783,GO:0005886,GO:0005887,GO:0006783,GO:0012505,GO:0016020,GO:0020037,GO:0030868,GO:0035579,GO:0042803,GO:0043005,GO:0043025,GO:0043312,GO:0044297,GO:0045202,GO:0046872" amyloid-beta binding|steroid binding|protein binding|mitochondrial outer membrane|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|heme biosynthetic process|endomembrane system|membrane|heme binding|smooth endoplasmic reticulum membrane|specific granule membrane|protein homodimerization activity|neuron projection|neuronal cell body|neutrophil degranulation|cell body|synapse|metal ion binding PGRMC2 1677.158238 1537.731719 1816.584757 1.1813405 0.240424855 0.311797378 1 24.39533757 28.33694999 10424 progesterone receptor membrane component 2 "GO:0003707,GO:0005496,GO:0005515,GO:0005635,GO:0005783,GO:0012505,GO:0015232,GO:0015886,GO:0016020,GO:0016021,GO:0020037,GO:0043401,GO:0060612" steroid hormone receptor activity|steroid binding|protein binding|nuclear envelope|endoplasmic reticulum|endomembrane system|heme transmembrane transporter activity|heme transport|membrane|integral component of membrane|heme binding|steroid hormone mediated signaling pathway|adipose tissue development PGS1 1310.791085 1255.779556 1365.802613 1.087613353 0.121165769 0.616126234 1 9.946370866 10.63678444 9489 phosphatidylglycerophosphate synthase 1 "GO:0005509,GO:0005524,GO:0005739,GO:0005743,GO:0005783,GO:0006655,GO:0008444,GO:0032049,GO:0046339" calcium ion binding|ATP binding|mitochondrion|mitochondrial inner membrane|endoplasmic reticulum|phosphatidylglycerol biosynthetic process|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity|cardiolipin biosynthetic process|diacylglycerol metabolic process hsa00564 Glycerophospholipid metabolism PHACTR1 89.74858061 97.79890497 81.69825626 0.835369847 -0.259513025 0.60576882 1 0.788540234 0.647699902 221692 phosphatase and actin regulator 1 "GO:0003779,GO:0004864,GO:0005515,GO:0005634,GO:0005829,GO:0008157,GO:0021987,GO:0030036,GO:0031032,GO:0031532,GO:0032515,GO:0043149,GO:0045202,GO:0048870,GO:0140059,GO:2001222" actin binding|protein phosphatase inhibitor activity|protein binding|nucleus|cytosol|protein phosphatase 1 binding|cerebral cortex development|actin cytoskeleton organization|actomyosin structure organization|actin cytoskeleton reorganization|negative regulation of phosphoprotein phosphatase activity|stress fiber assembly|synapse|cell motility|dendrite arborization|regulation of neuron migration PHACTR2 571.2349529 626.3291574 516.1407484 0.824072682 -0.279156509 0.293689605 1 3.419193534 2.770514194 9749 phosphatase and actin regulator 2 "GO:0002576,GO:0003779,GO:0004864,GO:0005515,GO:0005886,GO:0030036,GO:0031092,GO:0032515" platelet degranulation|actin binding|protein phosphatase inhibitor activity|protein binding|plasma membrane|actin cytoskeleton organization|platelet alpha granule membrane|negative regulation of phosphoprotein phosphatase activity PHACTR4 865.8714552 1018.565191 713.1777193 0.700178767 -0.514204783 0.03917754 1 8.423826469 5.7994863 65979 phosphatase and actin regulator 4 "GO:0001755,GO:0001843,GO:0003779,GO:0005737,GO:0007266,GO:0008157,GO:0030027,GO:0030036,GO:0043085,GO:0043666,GO:0048484,GO:0051726,GO:0061386,GO:0072542,GO:2001045" neural crest cell migration|neural tube closure|actin binding|cytoplasm|Rho protein signal transduction|protein phosphatase 1 binding|lamellipodium|actin cytoskeleton organization|positive regulation of catalytic activity|regulation of phosphoprotein phosphatase activity|enteric nervous system development|regulation of cell cycle|closure of optic fissure|protein phosphatase activator activity|negative regulation of integrin-mediated signaling pathway PHAF1 436.0994206 459.8629361 412.3359051 0.896649573 -0.157383832 0.581772273 1 6.043348857 5.328090456 80262 phagosome assembly factor 1 PHAX 735.3838013 747.0171677 723.7504349 0.968853818 -0.045649089 0.862679148 1 11.0465318 10.52338309 51808 phosphorylated adaptor for RNA export "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0006408,GO:0015030,GO:0015031,GO:0015643,GO:0042795,GO:0043025,GO:0051168" RNA binding|protein binding|nucleus|nucleoplasm|centrosome|cytosol|snRNA export from nucleus|Cajal body|protein transport|toxic substance binding|snRNA transcription by RNA polymerase II|neuronal cell body|nuclear export hsa03013 RNA transport PHB 2867.185856 2739.409753 2994.961959 1.093287324 0.128672602 0.587169048 1 72.3390716 77.76396966 5245 prohibitin "GO:0000122,GO:0001541,GO:0001552,GO:0001649,GO:0001850,GO:0001851,GO:0002377,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005743,GO:0005769,GO:0005886,GO:0005887,GO:0006355,GO:0006851,GO:0007005,GO:0007165,GO:0007202,GO:0008022,GO:0008285,GO:0009986,GO:0010628,GO:0010942,GO:0010944,GO:0014069,GO:0016020,GO:0016575,GO:0019899,GO:0023035,GO:0030061,GO:0030308,GO:0031100,GO:0031315,GO:0031871,GO:0032620,GO:0035632,GO:0035902,GO:0039529,GO:0042113,GO:0042177,GO:0042493,GO:0042826,GO:0042981,GO:0043066,GO:0043434,GO:0044830,GO:0045471,GO:0045745,GO:0045892,GO:0045893,GO:0045917,GO:0046718,GO:0046982,GO:0048661,GO:0050821,GO:0050847,GO:0051897,GO:0060766,GO:0070062,GO:0070373,GO:0070374,GO:0071354,GO:0071897,GO:0072538,GO:0098891,GO:0098978,GO:0098982,GO:0140374,GO:1901224,GO:1990051,GO:2000323" "negative regulation of transcription by RNA polymerase II|ovarian follicle development|ovarian follicle atresia|osteoblast differentiation|complement component C3a binding|complement component C3b binding|immunoglobulin production|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial inner membrane|early endosome|plasma membrane|integral component of plasma membrane|regulation of transcription, DNA-templated|mitochondrial calcium ion transmembrane transport|mitochondrion organization|signal transduction|activation of phospholipase C activity|protein C-terminus binding|negative regulation of cell population proliferation|cell surface|positive regulation of gene expression|positive regulation of cell death|negative regulation of transcription by competitive promoter binding|postsynaptic density|membrane|histone deacetylation|enzyme binding|CD40 signaling pathway|mitochondrial crista|negative regulation of cell growth|animal organ regeneration|extrinsic component of mitochondrial outer membrane|proteinase activated receptor binding|interleukin-17 production|mitochondrial prohibitin complex|response to immobilization stress|RIG-I signaling pathway|B cell activation|negative regulation of protein catabolic process|response to drug|histone deacetylase binding|regulation of apoptotic process|negative regulation of apoptotic process|response to peptide hormone|modulation by host of viral RNA genome replication|response to ethanol|positive regulation of G protein-coupled receptor signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of complement activation|viral entry into host cell|protein heterodimerization activity|positive regulation of smooth muscle cell proliferation|protein stabilization|progesterone receptor signaling pathway|positive regulation of protein kinase B signaling|negative regulation of androgen receptor signaling pathway|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|cellular response to interleukin-6|DNA biosynthetic process|T-helper 17 type immune response|extrinsic component of presynaptic active zone membrane|glutamatergic synapse|GABA-ergic synapse|antiviral innate immune response|positive regulation of NIK/NF-kappaB signaling|activation of protein kinase C activity|negative regulation of glucocorticoid receptor signaling pathway" PHB2 4774.105756 4959.652979 4588.558534 0.925177337 -0.112198169 0.639931613 1 181.5415391 165.147566 11331 prohibitin 2 "GO:0000187,GO:0000423,GO:0002377,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005741,GO:0005743,GO:0005886,GO:0006606,GO:0006851,GO:0007005,GO:0007062,GO:0007202,GO:0008022,GO:0009611,GO:0009986,GO:0014069,GO:0016363,GO:0016477,GO:0023035,GO:0030331,GO:0030424,GO:0030449,GO:0031536,GO:0032991,GO:0033147,GO:0033218,GO:0033600,GO:0035632,GO:0039520,GO:0039529,GO:0042113,GO:0042802,GO:0042803,GO:0043066,GO:0043433,GO:0045892,GO:0046625,GO:0046982,GO:0047485,GO:0048786,GO:0050821,GO:0051091,GO:0060744,GO:0060749,GO:0060762,GO:0070374,GO:0071300,GO:0071456,GO:0071944,GO:0098978,GO:0098982,GO:0140374,GO:1900208,GO:1901224,GO:1902808,GO:1904959,GO:1990051" "activation of MAPK activity|mitophagy|immunoglobulin production|protein binding|nucleus|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|plasma membrane|protein import into nucleus|mitochondrial calcium ion transmembrane transport|mitochondrion organization|sister chromatid cohesion|activation of phospholipase C activity|protein C-terminus binding|response to wounding|cell surface|postsynaptic density|nuclear matrix|cell migration|CD40 signaling pathway|estrogen receptor binding|axon|regulation of complement activation|positive regulation of exit from mitosis|protein-containing complex|negative regulation of intracellular estrogen receptor signaling pathway|amide binding|negative regulation of mammary gland epithelial cell proliferation|mitochondrial prohibitin complex|induction by virus of host autophagy|RIG-I signaling pathway|B cell activation|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|negative regulation of DNA-binding transcription factor activity|negative regulation of transcription, DNA-templated|sphingolipid binding|protein heterodimerization activity|protein N-terminus binding|presynaptic active zone|protein stabilization|positive regulation of DNA-binding transcription factor activity|mammary gland branching involved in thelarche|mammary gland alveolus development|regulation of branching involved in mammary gland duct morphogenesis|positive regulation of ERK1 and ERK2 cascade|cellular response to retinoic acid|cellular response to hypoxia|cell periphery|glutamatergic synapse|GABA-ergic synapse|antiviral innate immune response|regulation of cardiolipin metabolic process|positive regulation of NIK/NF-kappaB signaling|positive regulation of cell cycle G1/S phase transition|regulation of cytochrome-c oxidase activity|activation of protein kinase C activity" PHC1 653.1653381 745.9767539 560.3539223 0.751168075 -0.412792345 0.110836474 1 7.251622642 5.356036118 1911 polyhomeotic homolog 1 "GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0007275,GO:0008270,GO:0016574,GO:0031519,GO:0035102,GO:0042393,GO:0045892,GO:0070317" "DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|multicellular organism development|zinc ion binding|histone ubiquitination|PcG protein complex|PRC1 complex|histone binding|negative regulation of transcription, DNA-templated|negative regulation of G0 to G1 transition" PHC2 3494.033876 3400.072568 3587.995184 1.055270178 0.077612415 0.744468854 1 40.71250256 42.24376738 1912 polyhomeotic homolog 2 "GO:0000792,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0007275,GO:0007283,GO:0008270,GO:0031519,GO:0035102,GO:0042393,GO:0042802,GO:0045892" "heterochromatin|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|multicellular organism development|spermatogenesis|zinc ion binding|PcG protein complex|PRC1 complex|histone binding|identical protein binding|negative regulation of transcription, DNA-templated" PHC3 1512.899334 1590.792827 1435.005842 0.902069596 -0.148689351 0.534107413 1 6.545696947 5.805867474 80012 polyhomeotic homolog 3 "GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0007275,GO:0008270,GO:0031519,GO:0035102,GO:0042393,GO:0045892,GO:0070317" "DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|multicellular organism development|zinc ion binding|PcG protein complex|PRC1 complex|histone binding|negative regulation of transcription, DNA-templated|negative regulation of G0 to G1 transition" PHETA1 468.5359189 466.1054194 470.9664184 1.010428969 0.014967907 0.965532943 1 6.681490618 6.638199962 144717 PH domain containing endocytic trafficking adaptor 1 "GO:0001881,GO:0005515,GO:0005769,GO:0005802,GO:0005829,GO:0007032,GO:0030136,GO:0042147,GO:0042803,GO:0055037" "receptor recycling|protein binding|early endosome|trans-Golgi network|cytosol|endosome organization|clathrin-coated vesicle|retrograde transport, endosome to Golgi|protein homodimerization activity|recycling endosome" PHETA2 114.2530271 110.2838716 118.2221826 1.071980707 0.100278941 0.840548735 1 2.382853252 2.511628745 150368 PH domain containing endocytic trafficking adaptor 2 "GO:0001881,GO:0005515,GO:0005769,GO:0005802,GO:0005829,GO:0007032,GO:0030136,GO:0042147,GO:0042803,GO:0055037" "receptor recycling|protein binding|early endosome|trans-Golgi network|cytosol|endosome organization|clathrin-coated vesicle|retrograde transport, endosome to Golgi|protein homodimerization activity|recycling endosome" PHEX 2849.221417 2696.752784 3001.690051 1.113075722 0.154551741 0.514043893 1 20.49569064 22.43150671 5251 phosphate regulating endopeptidase homolog X-linked "GO:0001501,GO:0004222,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0006464,GO:0006508,GO:0007267,GO:0008270,GO:0016485,GO:0019637,GO:0030282,GO:0030324,GO:0042476,GO:0048471,GO:0060348,GO:0060416,GO:0071305,GO:0071374,GO:1904383,GO:1990418" skeletal system development|metalloendopeptidase activity|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|cellular protein modification process|proteolysis|cell-cell signaling|zinc ion binding|protein processing|organophosphate metabolic process|bone mineralization|lung development|odontogenesis|perinuclear region of cytoplasm|bone development|response to growth hormone|cellular response to vitamin D|cellular response to parathyroid hormone stimulus|response to sodium phosphate|response to insulin-like growth factor stimulus PHF1 738.6396355 618.0058463 859.2734247 1.390396919 0.47549679 0.061500709 1 13.60636806 18.6016809 5252 PHD finger protein 1 "GO:0001226,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0006325,GO:0006355,GO:0006974,GO:0035064,GO:0035098,GO:0035861,GO:0042802,GO:0045814,GO:0046872,GO:0061086,GO:0061087,GO:1990226" "RNA polymerase II transcription corepressor binding|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|chromatin organization|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|methylated histone binding|ESC/E(Z) complex|site of double-strand break|identical protein binding|negative regulation of gene expression, epigenetic|metal ion binding|negative regulation of histone H3-K27 methylation|positive regulation of histone H3-K27 methylation|histone methyltransferase binding" PHF10 761.5237105 676.2690237 846.7783972 1.252132461 0.324387191 0.200357968 1 16.65493072 20.50521294 55274 PHD finger protein 10 "GO:0003712,GO:0005654,GO:0007399,GO:0042393,GO:0045892,GO:0045944,GO:0046872,GO:0071564" "transcription coregulator activity|nucleoplasm|nervous system development|histone binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|npBAF complex" hsa05225 Hepatocellular carcinoma PHF12 1319.425783 1394.154603 1244.696963 0.89279694 -0.163596013 0.497228267 1 12.43789181 10.91869278 57649 PHD finger protein 12 "GO:0000122,GO:0001222,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0016580,GO:0017053,GO:0035091,GO:0045892,GO:0046872,GO:0070822" "negative regulation of transcription by RNA polymerase II|transcription corepressor binding|transcription coregulator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|Sin3 complex|transcription repressor complex|phosphatidylinositol binding|negative regulation of transcription, DNA-templated|metal ion binding|Sin3-type complex" PHF13 889.2870268 851.058556 927.5154975 1.089837463 0.124112989 0.620220294 1 11.91798241 12.77131601 148479 PHD finger protein 13 "GO:0000278,GO:0003682,GO:0005634,GO:0005654,GO:0006325,GO:0007059,GO:0007076,GO:0035064,GO:0046872,GO:0051301" mitotic cell cycle|chromatin binding|nucleus|nucleoplasm|chromatin organization|chromosome segregation|mitotic chromosome condensation|methylated histone binding|metal ion binding|cell division PHF14 737.0041728 701.2389569 772.7693886 1.102005787 0.1401318 0.584397212 1 3.322723458 3.60038755 9678 PHD finger protein 14 "GO:0005515,GO:0006357,GO:0042393,GO:0043972,GO:0043994,GO:0044154,GO:0046872,GO:0070776" protein binding|regulation of transcription by RNA polymerase II|histone binding|histone H3-K23 acetylation|histone acetyltransferase activity (H3-K23 specific)|histone H3-K14 acetylation|metal ion binding|MOZ/MORF histone acetyltransferase complex PHF19 1215.899571 1199.597207 1232.201936 1.027179731 0.038688639 0.876208707 1 11.13783893 11.24912007 26147 PHD finger protein 19 "GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0006355,GO:0035064,GO:0035098,GO:0045814,GO:0046872,GO:0061087" "DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|chromatin organization|regulation of transcription, DNA-templated|methylated histone binding|ESC/E(Z) complex|negative regulation of gene expression, epigenetic|metal ion binding|positive regulation of histone H3-K27 methylation" PHF2 1024.937736 1031.050158 1018.825313 0.988143308 -0.017207808 0.948353337 1 10.19930527 9.909727285 5253 PHD finger protein 2 "GO:0000776,GO:0000777,GO:0001889,GO:0003712,GO:0003713,GO:0005506,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0006482,GO:0008270,GO:0032452,GO:0032454,GO:0033169,GO:0035064,GO:0045893,GO:0051213,GO:0055114,GO:0061188" "kinetochore|condensed chromosome kinetochore|liver development|transcription coregulator activity|transcription coactivator activity|iron ion binding|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|protein demethylation|zinc ion binding|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|methylated histone binding|positive regulation of transcription, DNA-templated|dioxygenase activity|oxidation-reduction process|negative regulation of ribosomal DNA heterochromatin assembly" PHF20 2175.091858 2296.193439 2053.990278 0.894519705 -0.160814832 0.496922359 1 19.40516605 17.06783571 51230 PHD finger protein 20 "GO:0000123,GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0016573,GO:0031965,GO:0043981,GO:0043982,GO:0043984,GO:0044545,GO:0046872,GO:0071339,GO:1901796" histone acetyltransferase complex|DNA binding|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|histone acetylation|nuclear membrane|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|NSL complex|metal ion binding|MLL1 complex|regulation of signal transduction by p53 class mediator other PHF20L1 1348.571848 1515.883027 1181.26067 0.779255819 -0.359831072 0.133852794 1 8.794422337 6.738427354 51105 PHD finger protein 20 like 1 "GO:0005515,GO:0006357,GO:0016573,GO:0044545,GO:0046872" protein binding|regulation of transcription by RNA polymerase II|histone acetylation|NSL complex|metal ion binding PHF21A 1370.248162 1391.033361 1349.462962 0.970115455 -0.04377164 0.858002548 1 9.59628928 9.153726525 51317 PHD finger protein 21A "GO:0000118,GO:0000122,GO:0003677,GO:0003682,GO:0005515,GO:0005654,GO:0006325,GO:0007596,GO:0046872,GO:1990391" histone deacetylase complex|negative regulation of transcription by RNA polymerase II|DNA binding|chromatin binding|protein binding|nucleoplasm|chromatin organization|blood coagulation|metal ion binding|DNA repair complex PHF21B 185.4326737 174.7895323 196.075815 1.121782366 0.165792809 0.667245126 1 1.899836271 2.095540033 112885 PHD finger protein 21B GO:0046872 metal ion binding PHF23 827.4610443 830.2502783 824.6718102 0.99328098 -0.009726209 0.974424317 1 16.66375759 16.27482162 79142 PHD finger protein 23 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006914,GO:0031398,GO:0046872,GO:1901097,GO:1902902" protein binding|nucleus|nucleoplasm|cytoplasm|autophagy|positive regulation of protein ubiquitination|metal ion binding|negative regulation of autophagosome maturation|negative regulation of autophagosome assembly PHF3 2003.863288 2153.656737 1854.069839 0.86089385 -0.216092734 0.361329573 1 5.878513799 4.976091136 23469 PHD finger protein 3 "GO:0003674,GO:0005575,GO:0006351,GO:0007275,GO:0046872" "molecular_function|cellular_component|transcription, DNA-templated|multicellular organism development|metal ion binding" PHF5A 684.5274384 635.6928823 733.3619944 1.153641978 0.206195567 0.424129283 1 32.21819637 36.54630324 84844 PHD finger protein 5A "GO:0000398,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005686,GO:0005689,GO:0008270,GO:0016363,GO:0016607,GO:0045893,GO:0048863,GO:0071005,GO:0071011" "mRNA splicing, via spliceosome|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|U2 snRNP|U12-type spliceosomal complex|zinc ion binding|nuclear matrix|nuclear speck|positive regulation of transcription, DNA-templated|stem cell differentiation|U2-type precatalytic spliceosome|precatalytic spliceosome" hsa03040 Spliceosome PHF6 3422.983177 3313.718216 3532.248138 1.065947044 0.092135768 0.698467225 1 38.40326837 40.25084439 84295 PHD finger protein 6 "GO:0000122,GO:0000777,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0015631,GO:0019899,GO:0042393,GO:0042826,GO:0043021,GO:0046872,GO:0051219,GO:0097110" negative regulation of transcription by RNA polymerase II|condensed chromosome kinetochore|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|tubulin binding|enzyme binding|histone binding|histone deacetylase binding|ribonucleoprotein complex binding|metal ion binding|phosphoprotein binding|scaffold protein binding PHF7 108.8477824 107.1626299 110.5329349 1.031450376 0.044674414 0.943482101 1 2.64404651 2.681566723 51533 PHD finger protein 7 "GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0005886,GO:0016607,GO:0046872" protein binding|nucleus|nucleoplasm|Golgi apparatus|cytosol|plasma membrane|nuclear speck|metal ion binding PHF8 952.985017 996.7164996 909.2535344 0.912248904 -0.132500582 0.593675185 1 7.557960741 6.779367243 23133 PHD finger protein 8 "GO:0000082,GO:0003682,GO:0003712,GO:0005506,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0006482,GO:0007420,GO:0008270,GO:0016706,GO:0031965,GO:0032452,GO:0032454,GO:0033169,GO:0035064,GO:0035574,GO:0035575,GO:0045893,GO:0045943,GO:0051864,GO:0055114,GO:0061188,GO:0070544,GO:0071557,GO:0071558" "G1/S transition of mitotic cell cycle|chromatin binding|transcription coregulator activity|iron ion binding|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|protein demethylation|brain development|zinc ion binding|2-oxoglutarate-dependent dioxygenase activity|nuclear membrane|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|methylated histone binding|histone H4-K20 demethylation|histone demethylase activity (H4-K20 specific)|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase I|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|negative regulation of ribosomal DNA heterochromatin assembly|histone H3-K36 demethylation|histone H3-K27 demethylation|histone demethylase activity (H3-K27 specific)" other PHGDH 4054.577342 4818.156691 3290.997993 0.683040882 -0.549956165 0.021206031 0.821508434 35.08954246 23.56652682 26227 phosphoglycerate dehydrogenase "GO:0004617,GO:0005829,GO:0006520,GO:0006541,GO:0006544,GO:0006564,GO:0006566,GO:0007420,GO:0009055,GO:0009448,GO:0010468,GO:0019530,GO:0021510,GO:0021782,GO:0021915,GO:0022900,GO:0030060,GO:0031175,GO:0051287,GO:0070062,GO:0070314" phosphoglycerate dehydrogenase activity|cytosol|cellular amino acid metabolic process|glutamine metabolic process|glycine metabolic process|L-serine biosynthetic process|threonine metabolic process|brain development|electron transfer activity|gamma-aminobutyric acid metabolic process|regulation of gene expression|taurine metabolic process|spinal cord development|glial cell development|neural tube development|electron transport chain|L-malate dehydrogenase activity|neuron projection development|NAD binding|extracellular exosome|G1 to G0 transition "hsa00260,hsa00270" "Glycine, serine and threonine metabolism|Cysteine and methionine metabolism" PHIP 1841.117159 1931.008166 1751.226152 0.906897331 -0.140988861 0.55274 1 8.516185174 7.594066543 55023 pleckstrin homology domain interacting protein "GO:0001932,GO:0005158,GO:0005515,GO:0005634,GO:0006357,GO:0007010,GO:0008284,GO:0008286,GO:0008360,GO:0022604,GO:0043066,GO:0043568,GO:0045840,GO:0045893,GO:0045944,GO:0070577,GO:2001237" "regulation of protein phosphorylation|insulin receptor binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|cytoskeleton organization|positive regulation of cell population proliferation|insulin receptor signaling pathway|regulation of cell shape|regulation of cell morphogenesis|negative regulation of apoptotic process|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitotic nuclear division|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|lysine-acetylated histone binding|negative regulation of extrinsic apoptotic signaling pathway" PHKA1 870.3608177 909.3217334 831.3999019 0.914307743 -0.129248257 0.606448764 1 8.084096227 7.267667515 5255 phosphorylase kinase regulatory subunit alpha 1 "GO:0004689,GO:0005516,GO:0005829,GO:0005886,GO:0005964,GO:0005977,GO:0005980,GO:0006091,GO:0006468" phosphorylase kinase activity|calmodulin binding|cytosol|plasma membrane|phosphorylase kinase complex|glycogen metabolic process|glycogen catabolic process|generation of precursor metabolites and energy|protein phosphorylation "hsa04020,hsa04910,hsa04922" Calcium signaling pathway|Insulin signaling pathway|Glucagon signaling pathway PHKA2 739.0346963 830.2502783 647.8191143 0.780269674 -0.357955265 0.159025247 1 8.706805152 6.679973388 5256 phosphorylase kinase regulatory subunit alpha 2 "GO:0004689,GO:0005515,GO:0005516,GO:0005829,GO:0005886,GO:0005964,GO:0005975,GO:0005980,GO:0006091,GO:0006464,GO:0006468" phosphorylase kinase activity|protein binding|calmodulin binding|cytosol|plasma membrane|phosphorylase kinase complex|carbohydrate metabolic process|glycogen catabolic process|generation of precursor metabolites and energy|cellular protein modification process|protein phosphorylation "hsa04020,hsa04910,hsa04922" Calcium signaling pathway|Insulin signaling pathway|Glucagon signaling pathway PHKB 2209.783406 2172.384187 2247.182625 1.034431496 0.048838108 0.838015696 1 20.36110843 20.70972494 5257 phosphorylase kinase regulatory subunit beta "GO:0005515,GO:0005516,GO:0005829,GO:0005886,GO:0005964,GO:0005977,GO:0005980,GO:0006091,GO:0006468" protein binding|calmodulin binding|cytosol|plasma membrane|phosphorylase kinase complex|glycogen metabolic process|glycogen catabolic process|generation of precursor metabolites and energy|protein phosphorylation "hsa04020,hsa04910,hsa04922" Calcium signaling pathway|Insulin signaling pathway|Glucagon signaling pathway PHKG1 18.81676865 14.56579436 23.06774294 1.583692752 0.663292469 0.469275015 1 0.234707027 0.365483858 5260 phosphorylase kinase catalytic subunit gamma 1 "GO:0004689,GO:0005516,GO:0005524,GO:0005829,GO:0005964,GO:0005975,GO:0005978,GO:0005980,GO:0006468,GO:0019899,GO:0050321,GO:0106310,GO:0106311" phosphorylase kinase activity|calmodulin binding|ATP binding|cytosol|phosphorylase kinase complex|carbohydrate metabolic process|glycogen biosynthetic process|glycogen catabolic process|protein phosphorylation|enzyme binding|tau-protein kinase activity|protein serine kinase activity|protein threonine kinase activity "hsa04020,hsa04910,hsa04922" Calcium signaling pathway|Insulin signaling pathway|Glucagon signaling pathway PHKG2 556.7785989 524.3685969 589.188601 1.123615343 0.16814823 0.53171213 1 12.57734304 13.89561414 5261 phosphorylase kinase catalytic subunit gamma 2 "GO:0004674,GO:0004689,GO:0005515,GO:0005516,GO:0005524,GO:0005829,GO:0005964,GO:0005977,GO:0005978,GO:0005980,GO:0006091,GO:0006468,GO:0045819,GO:0050321" protein serine/threonine kinase activity|phosphorylase kinase activity|protein binding|calmodulin binding|ATP binding|cytosol|phosphorylase kinase complex|glycogen metabolic process|glycogen biosynthetic process|glycogen catabolic process|generation of precursor metabolites and energy|protein phosphorylation|positive regulation of glycogen catabolic process|tau-protein kinase activity "hsa04020,hsa04910,hsa04922" Calcium signaling pathway|Insulin signaling pathway|Glucagon signaling pathway PHLDA1 12892.49537 11356.11753 14428.87321 1.270581532 0.345488955 0.180620115 1 102.4953697 128.0495225 22822 pleckstrin homology like domain family A member 1 "GO:0000086,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006915,GO:0031410,GO:0043065,GO:0045210,GO:1901981" G2/M transition of mitotic cell cycle|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|apoptotic process|cytoplasmic vesicle|positive regulation of apoptotic process|FasL biosynthetic process|phosphatidylinositol phosphate binding PHLDA2 866.5564372 809.4420007 923.6708737 1.141120516 0.190451166 0.446351091 1 46.95481727 52.68449809 7262 pleckstrin homology like domain family A member 2 "GO:0001890,GO:0005515,GO:0005737,GO:0006915,GO:0009887,GO:0010468,GO:0016020,GO:0030334,GO:0043065,GO:0045995,GO:0060721,GO:0070873,GO:1901981,GO:1903547" placenta development|protein binding|cytoplasm|apoptotic process|animal organ morphogenesis|regulation of gene expression|membrane|regulation of cell migration|positive regulation of apoptotic process|regulation of embryonic development|regulation of spongiotrophoblast cell proliferation|regulation of glycogen metabolic process|phosphatidylinositol phosphate binding|regulation of growth hormone activity PHLDA3 539.6067395 502.5199053 576.6935736 1.147603443 0.198624202 0.462134823 1 9.755752548 11.00838975 23612 pleckstrin homology like domain family A member 3 "GO:0005546,GO:0005547,GO:0005737,GO:0005886,GO:0009653,GO:0010314,GO:0032266,GO:0042771,GO:0043065,GO:0043325,GO:0051898,GO:0080025" "phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|plasma membrane|anatomical structure morphogenesis|phosphatidylinositol-5-phosphate binding|phosphatidylinositol-3-phosphate binding|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of apoptotic process|phosphatidylinositol-3,4-bisphosphate binding|negative regulation of protein kinase B signaling|phosphatidylinositol-3,5-bisphosphate binding" PHLDB1 1582.369291 1723.965804 1440.772778 0.835731646 -0.258888329 0.27697227 1 8.899679476 7.313283205 23187 pleckstrin homology like domain family B member 1 "GO:0010470,GO:0010717,GO:0045180,GO:0070507,GO:1904261" regulation of gastrulation|regulation of epithelial to mesenchymal transition|basal cortex|regulation of microtubule cytoskeleton organization|positive regulation of basement membrane assembly involved in embryonic body morphogenesis PHLDB2 1359.615081 1540.85296 1178.377202 0.764756425 -0.386927772 0.106794879 1 12.64726092 9.510224995 90102 pleckstrin homology like domain family B member 2 "GO:0000226,GO:0005515,GO:0005829,GO:0005886,GO:0005925,GO:0010470,GO:0010717,GO:0031252,GO:0045111,GO:0045180,GO:0045184,GO:0045296,GO:0051497,GO:0051895,GO:0070507,GO:1903690,GO:1904261" "microtubule cytoskeleton organization|protein binding|cytosol|plasma membrane|focal adhesion|regulation of gastrulation|regulation of epithelial to mesenchymal transition|cell leading edge|intermediate filament cytoskeleton|basal cortex|establishment of protein localization|cadherin binding|negative regulation of stress fiber assembly|negative regulation of focal adhesion assembly|regulation of microtubule cytoskeleton organization|negative regulation of wound healing, spreading of epidermal cells|positive regulation of basement membrane assembly involved in embryonic body morphogenesis" PHLDB3 119.9356745 120.6880104 119.1833385 0.987532549 -0.018099795 0.988669214 1 1.963688201 1.906756028 653583 pleckstrin homology like domain family B member 3 GO:0019899 enzyme binding PHLPP1 503.2759275 520.2069413 486.3449137 0.934906621 -0.09710582 0.727376852 1 4.439157077 4.080749411 23239 PH domain and leucine rich repeat protein phosphatase 1 "GO:0002667,GO:0004722,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006470,GO:0006915,GO:0007165,GO:0009649,GO:0042981,GO:0043231,GO:0043408,GO:0046328,GO:0046872,GO:0051898,GO:0106306,GO:0106307,GO:1900744" regulation of T cell anergy|protein serine/threonine phosphatase activity|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|protein dephosphorylation|apoptotic process|signal transduction|entrainment of circadian clock|regulation of apoptotic process|intracellular membrane-bounded organelle|regulation of MAPK cascade|regulation of JNK cascade|metal ion binding|negative regulation of protein kinase B signaling|protein serine phosphatase activity|protein threonine phosphatase activity|regulation of p38MAPK cascade hsa04151 PI3K-Akt signaling pathway PHLPP2 642.7863514 662.7436432 622.8290595 0.939773721 -0.089614669 0.734562453 1 3.913844215 3.61657945 23035 PH domain and leucine rich repeat protein phosphatase 2 "GO:0004722,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006470,GO:0007165,GO:0016020,GO:0043231,GO:0045171,GO:0046872,GO:0051898,GO:0072686,GO:0106306,GO:0106307" protein serine/threonine phosphatase activity|protein binding|nucleoplasm|cytoplasm|cytosol|protein dephosphorylation|signal transduction|membrane|intracellular membrane-bounded organelle|intercellular bridge|metal ion binding|negative regulation of protein kinase B signaling|mitotic spindle|protein serine phosphatase activity|protein threonine phosphatase activity hsa04151 PI3K-Akt signaling pathway PHOSPHO1 8.927806347 7.282897178 10.57271552 1.451718356 0.537761587 0.724794316 1 0.169727003 0.242272706 162466 phosphoethanolamine/phosphocholine phosphatase 1 "GO:0001958,GO:0005515,GO:0005829,GO:0006646,GO:0006656,GO:0016311,GO:0016462,GO:0016791,GO:0030500,GO:0031012,GO:0035630,GO:0046872,GO:0052731,GO:0052732,GO:0065010" endochondral ossification|protein binding|cytosol|phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process|dephosphorylation|pyrophosphatase activity|phosphatase activity|regulation of bone mineralization|extracellular matrix|bone mineralization involved in bone maturation|metal ion binding|phosphocholine phosphatase activity|phosphoethanolamine phosphatase activity|extracellular membrane-bounded organelle hsa00564 Glycerophospholipid metabolism PHOSPHO2 38.3864876 48.89945248 27.87352272 0.570017072 -0.810922966 0.222118095 1 2.291197459 1.284167163 493911 "phosphatase, orphan 2" "GO:0005515,GO:0016311,GO:0016791,GO:0033883,GO:0046872" protein binding|dephosphorylation|phosphatase activity|pyridoxal phosphatase activity|metal ion binding hsa00750 Vitamin B6 metabolism PHPT1 741.3249585 612.8037769 869.8461402 1.419452968 0.505335048 0.046820878 1 51.50269494 71.88232911 29085 phosphohistidine phosphatase 1 "GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006470,GO:0016604,GO:0019855,GO:0035774,GO:0035971,GO:0044325,GO:0050860,GO:0051350,GO:0070062,GO:0101006,GO:2000147,GO:2000249,GO:2000984" protein binding|nucleoplasm|cytosol|plasma membrane|protein dephosphorylation|nuclear body|calcium channel inhibitor activity|positive regulation of insulin secretion involved in cellular response to glucose stimulus|peptidyl-histidine dephosphorylation|ion channel binding|negative regulation of T cell receptor signaling pathway|negative regulation of lyase activity|extracellular exosome|protein histidine phosphatase activity|positive regulation of cell motility|regulation of actin cytoskeleton reorganization|negative regulation of ATP citrate synthase activity PHRF1 1529.2396 1489.87268 1568.60652 1.052846019 0.074294455 0.757432144 1 14.31612651 14.82045598 57661 PHD and ring finger domains 1 "GO:0006366,GO:0006397,GO:0016020,GO:0019904,GO:0046872,GO:0070063" transcription by RNA polymerase II|mRNA processing|membrane|protein domain specific binding|metal ion binding|RNA polymerase binding PHTF1 688.906746 700.198543 677.614949 0.967746871 -0.047298357 0.859241041 1 8.243615559 7.844236602 10745 putative homeodomain transcription factor 1 "GO:0005789,GO:0005801,GO:0016021" endoplasmic reticulum membrane|cis-Golgi network|integral component of membrane PHTF2 1544.077767 1538.772132 1549.383401 1.006895932 0.009914582 0.96983471 1 13.15416315 13.02323835 57157 putative homeodomain transcription factor 2 "GO:0005783,GO:0016021" endoplasmic reticulum|integral component of membrane PHYH 340.2373044 327.730373 352.7442358 1.076324518 0.106113125 0.733513955 1 9.249268993 9.788627952 5264 phytanoyl-CoA 2-hydroxylase "GO:0001561,GO:0005515,GO:0005739,GO:0005777,GO:0005782,GO:0005829,GO:0006103,GO:0006625,GO:0006720,GO:0008198,GO:0019606,GO:0031406,GO:0031418,GO:0048244,GO:0097089,GO:0097731" fatty acid alpha-oxidation|protein binding|mitochondrion|peroxisome|peroxisomal matrix|cytosol|2-oxoglutarate metabolic process|protein targeting to peroxisome|isoprenoid metabolic process|ferrous iron binding|2-oxobutyrate catabolic process|carboxylic acid binding|L-ascorbic acid binding|phytanoyl-CoA dioxygenase activity|methyl-branched fatty acid metabolic process|9+0 non-motile cilium hsa04146 Peroxisome PHYHIP 20.05532735 21.84869154 18.26196316 0.835837841 -0.258705019 0.811013347 1 0.272754272 0.224163433 9796 phytanoyl-CoA 2-hydroxylase interacting protein "GO:0005737,GO:0008104,GO:1990782" cytoplasm|protein localization|protein tyrosine kinase binding PHYKPL 270.2861557 295.4775427 245.0947688 0.829486961 -0.269708793 0.411497709 1 4.227638978 3.448090336 85007 5-phosphohydroxy-L-lysine phospho-lyase "GO:0005515,GO:0005759,GO:0006554,GO:0008483,GO:0016829,GO:0030170,GO:0030574,GO:0042802" protein binding|mitochondrial matrix|lysine catabolic process|transaminase activity|lyase activity|pyridoxal phosphate binding|collagen catabolic process|identical protein binding hsa00310 Lysine degradation PI15 3.562190663 5.202069413 1.922311912 0.369528309 -1.436243205 0.543489417 1 0.041050552 0.014915503 51050 peptidase inhibitor 15 "GO:0005615,GO:0007275,GO:0008150,GO:0010466,GO:0030414,GO:0070062" extracellular space|multicellular organism development|biological_process|negative regulation of peptidase activity|peptidase inhibitor activity|extracellular exosome PI3 90.09579483 31.21241648 148.9791732 4.773073987 2.2549187 1.19E-05 0.005826306 3.023138478 14.18820275 5266 peptidase inhibitor 3 "GO:0001533,GO:0004866,GO:0004867,GO:0005576,GO:0005615,GO:0005829,GO:0007620,GO:0010951,GO:0018149,GO:0019730,GO:0019731,GO:0030280,GO:0031012,GO:0045087,GO:0070268" cornified envelope|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|cytosol|copulation|negative regulation of endopeptidase activity|peptide cross-linking|antimicrobial humoral response|antibacterial humoral response|structural constituent of skin epidermis|extracellular matrix|innate immune response|cornification PI4K2A 4257.058457 4128.362286 4385.754627 1.062347324 0.087255518 0.715170202 1 52.59563323 54.9398406 55361 phosphatidylinositol 4-kinase type 2 alpha "GO:0000287,GO:0004430,GO:0005515,GO:0005524,GO:0005739,GO:0005765,GO:0005768,GO:0005802,GO:0005829,GO:0005886,GO:0005887,GO:0006661,GO:0007030,GO:0007032,GO:0016020,GO:0030425,GO:0031083,GO:0031224,GO:0031410,GO:0035651,GO:0035838,GO:0042734,GO:0043005,GO:0043025,GO:0043204,GO:0045121,GO:0046854" magnesium ion binding|1-phosphatidylinositol 4-kinase activity|protein binding|ATP binding|mitochondrion|lysosomal membrane|endosome|trans-Golgi network|cytosol|plasma membrane|integral component of plasma membrane|phosphatidylinositol biosynthetic process|Golgi organization|endosome organization|membrane|dendrite|BLOC-1 complex|intrinsic component of membrane|cytoplasmic vesicle|AP-3 adaptor complex binding|growing cell tip|presynaptic membrane|neuron projection|neuronal cell body|perikaryon|membrane raft|phosphatidylinositol phosphorylation "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system PI4K2B 1130.149714 1017.524777 1242.774651 1.221370407 0.288500795 0.235872742 1 14.83294926 17.81336975 55300 phosphatidylinositol 4-kinase type 2 beta "GO:0004430,GO:0005524,GO:0005768,GO:0005802,GO:0005829,GO:0005886,GO:0006661,GO:0007030,GO:0007032,GO:0016020,GO:0046854" 1-phosphatidylinositol 4-kinase activity|ATP binding|endosome|trans-Golgi network|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|Golgi organization|endosome organization|membrane|phosphatidylinositol phosphorylation "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system PI4KA 1418.859536 1607.439449 1230.279624 0.765366076 -0.385778138 0.106955527 1 12.50343813 9.40957129 5297 phosphatidylinositol 4-kinase alpha "GO:0004430,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0006661,GO:0007165,GO:0016020,GO:0016301,GO:0016310,GO:0019034,GO:0030660,GO:0039694,GO:0044803,GO:0045296,GO:0046786,GO:0046854,GO:0048015,GO:0052742,GO:0070062" 1-phosphatidylinositol 4-kinase activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|focal adhesion|phosphatidylinositol biosynthetic process|signal transduction|membrane|kinase activity|phosphorylation|viral replication complex|Golgi-associated vesicle membrane|viral RNA genome replication|multi-organism membrane organization|cadherin binding|viral replication complex formation and maintenance|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|phosphatidylinositol kinase activity|extracellular exosome "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system PI4KB 1833.927997 1981.988446 1685.867547 0.850594033 -0.23345736 0.324751985 1 25.68603221 21.48278259 5298 phosphatidylinositol 4-kinase beta "GO:0000139,GO:0004430,GO:0005515,GO:0005524,GO:0005737,GO:0005741,GO:0005768,GO:0005829,GO:0006661,GO:0006898,GO:0007165,GO:0016020,GO:0016032,GO:0030867,GO:0046854,GO:0048015,GO:0048471,GO:0052742,GO:0071889" Golgi membrane|1-phosphatidylinositol 4-kinase activity|protein binding|ATP binding|cytoplasm|mitochondrial outer membrane|endosome|cytosol|phosphatidylinositol biosynthetic process|receptor-mediated endocytosis|signal transduction|membrane|viral process|rough endoplasmic reticulum membrane|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|phosphatidylinositol kinase activity|14-3-3 protein binding "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system PIANP 132.9163103 108.2030438 157.6295768 1.456794294 0.542797177 0.201361394 1 1.076948448 1.542639065 196500 PILR alpha associated neural protein "GO:0005515,GO:0005886,GO:0016020,GO:0016021,GO:0016323,GO:0050776" protein binding|plasma membrane|membrane|integral component of membrane|basolateral plasma membrane|regulation of immune response PIAS1 874.1362444 882.2709725 866.0015164 0.98155957 -0.026852269 0.918905321 1 7.274089334 7.020474571 8554 protein inhibitor of activated STAT 1 "GO:0000082,GO:0000122,GO:0001085,GO:0003677,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007259,GO:0007283,GO:0008022,GO:0008270,GO:0008542,GO:0016605,GO:0016607,GO:0016925,GO:0019789,GO:0019899,GO:0019904,GO:0031625,GO:0032436,GO:0033235,GO:0042127,GO:0043066,GO:0045444,GO:0045893,GO:0051152,GO:0060334,GO:0061665,GO:0065004" "G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription factor binding|DNA binding|transcription coregulator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|receptor signaling pathway via JAK-STAT|spermatogenesis|protein C-terminus binding|zinc ion binding|visual learning|PML body|nuclear speck|protein sumoylation|SUMO transferase activity|enzyme binding|protein domain specific binding|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein sumoylation|regulation of cell population proliferation|negative regulation of apoptotic process|fat cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of smooth muscle cell differentiation|regulation of interferon-gamma-mediated signaling pathway|SUMO ligase activity|protein-DNA complex assembly" "hsa04120,hsa04630,hsa05160" Ubiquitin mediated proteolysis|JAK-STAT signaling pathway|Hepatitis C zf-MIZ PIAS2 577.1163594 541.015219 613.2174999 1.133457024 0.180729691 0.497760701 1 1.451195612 1.617343223 9063 protein inhibitor of activated STAT 2 "GO:0001085,GO:0003677,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008134,GO:0008270,GO:0016605,GO:0016607,GO:0016925,GO:0019789,GO:0031625,GO:0060766,GO:0061665" RNA polymerase II transcription factor binding|DNA binding|transcription coregulator activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription factor binding|zinc ion binding|PML body|nuclear speck|protein sumoylation|SUMO transferase activity|ubiquitin protein ligase binding|negative regulation of androgen receptor signaling pathway|SUMO ligase activity "hsa04120,hsa04630" Ubiquitin mediated proteolysis|JAK-STAT signaling pathway PIAS3 1227.155425 1293.234456 1161.076395 0.897808119 -0.155520952 0.521176036 1 23.78275192 20.99504515 10401 protein inhibitor of activated STAT 3 "GO:0000122,GO:0001085,GO:0003712,GO:0005515,GO:0005654,GO:0005737,GO:0006357,GO:0008022,GO:0008270,GO:0009725,GO:0010628,GO:0015459,GO:0016607,GO:0016925,GO:0019789,GO:0019899,GO:0030425,GO:0033234,GO:0033235,GO:0045202,GO:0045671,GO:0045838,GO:0047485,GO:0061665,GO:0071847" negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription factor binding|transcription coregulator activity|protein binding|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|protein C-terminus binding|zinc ion binding|response to hormone|positive regulation of gene expression|potassium channel regulator activity|nuclear speck|protein sumoylation|SUMO transferase activity|enzyme binding|dendrite|negative regulation of protein sumoylation|positive regulation of protein sumoylation|synapse|negative regulation of osteoclast differentiation|positive regulation of membrane potential|protein N-terminus binding|SUMO ligase activity|TNFSF11-mediated signaling pathway "hsa04120,hsa04630" Ubiquitin mediated proteolysis|JAK-STAT signaling pathway PIAS4 313.3746275 303.8008537 322.9484012 1.063026641 0.088177754 0.785102763 1 4.488730122 4.691792778 51588 protein inhibitor of activated STAT 4 "GO:0000122,GO:0001085,GO:0003677,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006303,GO:0006357,GO:0008022,GO:0008270,GO:0010804,GO:0016055,GO:0016363,GO:0016605,GO:0016925,GO:0019789,GO:0031625,GO:0032088,GO:0033235,GO:0042359,GO:0045892,GO:0061665,GO:1902174,GO:1902231,GO:1990234" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription factor binding|DNA binding|transcription coregulator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|double-strand break repair via nonhomologous end joining|regulation of transcription by RNA polymerase II|protein C-terminus binding|zinc ion binding|negative regulation of tumor necrosis factor-mediated signaling pathway|Wnt signaling pathway|nuclear matrix|PML body|protein sumoylation|SUMO transferase activity|ubiquitin protein ligase binding|negative regulation of NF-kappaB transcription factor activity|positive regulation of protein sumoylation|vitamin D metabolic process|negative regulation of transcription, DNA-templated|SUMO ligase activity|positive regulation of keratinocyte apoptotic process|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage|transferase complex" "hsa04064,hsa04120,hsa04630,hsa05418" NF-kappa B signaling pathway|Ubiquitin mediated proteolysis|JAK-STAT signaling pathway|Fluid shear stress and atherosclerosis zf-MIZ PIBF1 417.6198054 403.6805865 431.5590242 1.069060635 0.096343683 0.742643106 1 6.38710079 6.713937382 10464 progesterone immunomodulatory binding factor 1 "GO:0002376,GO:0005136,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005813,GO:0007080,GO:0031393,GO:0032695,GO:0032733,GO:0032815,GO:0034451,GO:0042531,GO:0042532,GO:0042976,GO:0060271,GO:0071539,GO:0090307,GO:1905515" immune system process|interleukin-4 receptor binding|protein binding|extracellular space|nucleus|cytoplasm|centrosome|mitotic metaphase plate congression|negative regulation of prostaglandin biosynthetic process|negative regulation of interleukin-12 production|positive regulation of interleukin-10 production|negative regulation of natural killer cell activation|centriolar satellite|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of tyrosine phosphorylation of STAT protein|activation of Janus kinase activity|cilium assembly|protein localization to centrosome|mitotic spindle assembly|non-motile cilium assembly PICALM 6439.477142 5733.720907 7145.233377 1.246177394 0.317509451 0.191775449 1 70.47400891 86.35351583 8301 phosphatidylinositol binding clathrin assembly protein "GO:0000149,GO:0001540,GO:0005515,GO:0005545,GO:0005546,GO:0005634,GO:0005769,GO:0005794,GO:0005829,GO:0005886,GO:0005905,GO:0006897,GO:0006898,GO:0006900,GO:0007409,GO:0007611,GO:0008021,GO:0009986,GO:0010629,GO:0016020,GO:0016185,GO:0016188,GO:0016192,GO:0016197,GO:0030097,GO:0030100,GO:0030122,GO:0030132,GO:0030136,GO:0030276,GO:0031224,GO:0031267,GO:0031623,GO:0031982,GO:0032050,GO:0032880,GO:0035459,GO:0042734,GO:0043025,GO:0043231,GO:0043547,GO:0045211,GO:0045296,GO:0045334,GO:0045893,GO:0048156,GO:0048261,GO:0048268,GO:0048471,GO:0048813,GO:0050750,GO:0055072,GO:0061024,GO:0065003,GO:0070381,GO:0072583,GO:0090647,GO:0097418,GO:0097494,GO:0097753,GO:0098894,GO:0150093,GO:1901216,GO:1902003,GO:1902004,GO:1902959,GO:1902961,GO:1902963,GO:1903077,GO:1905224,GO:2000009" "SNARE binding|amyloid-beta binding|protein binding|1-phosphatidylinositol binding|phosphatidylinositol-4,5-bisphosphate binding|nucleus|early endosome|Golgi apparatus|cytosol|plasma membrane|clathrin-coated pit|endocytosis|receptor-mediated endocytosis|vesicle budding from membrane|axonogenesis|learning or memory|synaptic vesicle|cell surface|negative regulation of gene expression|membrane|synaptic vesicle budding from presynaptic endocytic zone membrane|synaptic vesicle maturation|vesicle-mediated transport|endosomal transport|hemopoiesis|regulation of endocytosis|AP-2 adaptor complex|clathrin coat of coated pit|clathrin-coated vesicle|clathrin binding|intrinsic component of membrane|small GTPase binding|receptor internalization|vesicle|clathrin heavy chain binding|regulation of protein localization|vesicle cargo loading|presynaptic membrane|neuronal cell body|intracellular membrane-bounded organelle|positive regulation of GTPase activity|postsynaptic membrane|cadherin binding|clathrin-coated endocytic vesicle|positive regulation of transcription, DNA-templated|tau protein binding|negative regulation of receptor-mediated endocytosis|clathrin coat assembly|perinuclear region of cytoplasm|dendrite morphogenesis|low-density lipoprotein particle receptor binding|iron ion homeostasis|membrane organization|protein-containing complex assembly|endosome to plasma membrane transport vesicle|clathrin-dependent endocytosis|modulation of age-related behavioral decline|neurofibrillary tangle|regulation of vesicle size|membrane bending|extrinsic component of presynaptic endocytic zone membrane|amyloid-beta clearance by transcytosis|positive regulation of neuron death|regulation of amyloid-beta formation|positive regulation of amyloid-beta formation|regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of protein localization to plasma membrane|clathrin-coated pit assembly|negative regulation of protein localization to cell surface" PICK1 444.8888328 413.0443114 476.7333542 1.154194214 0.206886003 0.464704019 1 7.778198926 8.827325015 9463 protein interacting with PRKCA 1 "GO:0001664,GO:0002092,GO:0005080,GO:0005102,GO:0005515,GO:0005543,GO:0005737,GO:0005794,GO:0005829,GO:0005856,GO:0005886,GO:0006468,GO:0006886,GO:0006890,GO:0007205,GO:0008021,GO:0008022,GO:0014069,GO:0015844,GO:0019899,GO:0019904,GO:0021782,GO:0030666,GO:0032588,GO:0034315,GO:0034316,GO:0036294,GO:0042149,GO:0042734,GO:0042802,GO:0043005,GO:0043045,GO:0043046,GO:0043113,GO:0045161,GO:0045202,GO:0046872,GO:0048471,GO:0050796,GO:0051015,GO:0060292,GO:0071933,GO:0097061,GO:0097062,GO:0098842,GO:0140090" "G protein-coupled receptor binding|positive regulation of receptor internalization|protein kinase C binding|signaling receptor binding|protein binding|phospholipid binding|cytoplasm|Golgi apparatus|cytosol|cytoskeleton|plasma membrane|protein phosphorylation|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|protein kinase C-activating G protein-coupled receptor signaling pathway|synaptic vesicle|protein C-terminus binding|postsynaptic density|monoamine transport|enzyme binding|protein domain specific binding|glial cell development|endocytic vesicle membrane|trans-Golgi network membrane|regulation of Arp2/3 complex-mediated actin nucleation|negative regulation of Arp2/3 complex-mediated actin nucleation|cellular response to decreased oxygen levels|cellular response to glucose starvation|presynaptic membrane|identical protein binding|neuron projection|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|receptor clustering|neuronal ion channel clustering|synapse|metal ion binding|perinuclear region of cytoplasm|regulation of insulin secretion|actin filament binding|long-term synaptic depression|Arp2/3 complex binding|dendritic spine organization|dendritic spine maintenance|postsynaptic early endosome|membrane curvature sensor activity" PID1 626.3919799 699.1581291 553.6258307 0.791846376 -0.336707531 0.19687054 1 4.494974624 3.499768809 55022 phosphotyrosine interaction domain containing 1 "GO:0001933,GO:0005515,GO:0005737,GO:0006112,GO:0010628,GO:0010635,GO:0044320,GO:0045444,GO:0045944,GO:0046325,GO:0046627,GO:0051881,GO:0070346,GO:0070584,GO:0071345,GO:0071354,GO:0071356,GO:0071398,GO:1903077,GO:2000377,GO:2000379,GO:2001170,GO:2001171" negative regulation of protein phosphorylation|protein binding|cytoplasm|energy reserve metabolic process|positive regulation of gene expression|regulation of mitochondrial fusion|cellular response to leptin stimulus|fat cell differentiation|positive regulation of transcription by RNA polymerase II|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|regulation of mitochondrial membrane potential|positive regulation of fat cell proliferation|mitochondrion morphogenesis|cellular response to cytokine stimulus|cellular response to interleukin-6|cellular response to tumor necrosis factor|cellular response to fatty acid|negative regulation of protein localization to plasma membrane|regulation of reactive oxygen species metabolic process|positive regulation of reactive oxygen species metabolic process|negative regulation of ATP biosynthetic process|positive regulation of ATP biosynthetic process PIDD1 311.7051806 272.5884373 350.8219239 1.28700222 0.364014542 0.242621868 1 3.328195813 4.21171858 55367 p53-induced death domain protein 1 "GO:0004175,GO:0005123,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006915,GO:0006919,GO:0006974,GO:0006977,GO:0007165,GO:0008625,GO:0016540,GO:0042981,GO:0043065,GO:0043066,GO:0043122,GO:0051092" "endopeptidase activity|death receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|signal transduction|extrinsic apoptotic signaling pathway via death domain receptors|protein autoprocessing|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of NF-kappaB transcription factor activity" "hsa04064,hsa04115,hsa04210" NF-kappa B signaling pathway|p53 signaling pathway|Apoptosis PIEZO1 3659.413795 3944.209029 3374.618561 0.855588164 -0.22501157 0.343674717 1 26.02239915 21.89189118 9780 piezo type mechanosensitive ion channel component 1 "GO:0005261,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0006812,GO:0008381,GO:0016020,GO:0016021,GO:0031258,GO:0033116,GO:0033625,GO:0033634,GO:0042391,GO:0050982,GO:0071260,GO:0098655" cation channel activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|cation transport|mechanosensitive ion channel activity|membrane|integral component of membrane|lamellipodium membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|positive regulation of integrin activation|positive regulation of cell-cell adhesion mediated by integrin|regulation of membrane potential|detection of mechanical stimulus|cellular response to mechanical stimulus|cation transmembrane transport PIF1 389.4883872 447.3779695 331.5988048 0.741205038 -0.432055408 0.137856452 1 8.216015137 5.987848061 80119 PIF1 5'-to-3' DNA helicase "GO:0000002,GO:0000287,GO:0000723,GO:0000781,GO:0005524,GO:0005634,GO:0005657,GO:0005739,GO:0006260,GO:0006281,GO:0006310,GO:0010521,GO:0017116,GO:0032204,GO:0032211,GO:0032508,GO:0033678,GO:0042162,GO:0043139,GO:0051880,GO:0051974" "mitochondrial genome maintenance|magnesium ion binding|telomere maintenance|chromosome, telomeric region|ATP binding|nucleus|replication fork|mitochondrion|DNA replication|DNA repair|DNA recombination|telomerase inhibitor activity|single-stranded DNA helicase activity|regulation of telomere maintenance|negative regulation of telomere maintenance via telomerase|DNA duplex unwinding|5'-3' DNA/RNA helicase activity|telomeric DNA binding|5'-3' DNA helicase activity|G-quadruplex DNA binding|negative regulation of telomerase activity" PIFO 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.043109454 0.058738477 128344 primary cilia formation "GO:0005515,GO:0005634,GO:0005802,GO:0008092,GO:0019894,GO:0019901,GO:0031267,GO:0031344,GO:0031410,GO:0033674,GO:0036064,GO:0043015,GO:0044782,GO:0048487,GO:0060971" protein binding|nucleus|trans-Golgi network|cytoskeletal protein binding|kinesin binding|protein kinase binding|small GTPase binding|regulation of cell projection organization|cytoplasmic vesicle|positive regulation of kinase activity|ciliary basal body|gamma-tubulin binding|cilium organization|beta-tubulin binding|embryonic heart tube left/right pattern formation PIGA 504.6736165 430.7313474 578.6158855 1.343333586 0.425817609 0.118479093 1 4.378541021 5.783416564 5277 phosphatidylinositol glycan anchor biosynthesis class A "GO:0000506,GO:0005515,GO:0005789,GO:0006506,GO:0008194,GO:0009893,GO:0016020,GO:0016021,GO:0016254,GO:0017176,GO:1990830" glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|protein binding|endoplasmic reticulum membrane|GPI anchor biosynthetic process|UDP-glycosyltransferase activity|positive regulation of metabolic process|membrane|integral component of membrane|preassembly of GPI anchor in ER membrane|phosphatidylinositol N-acetylglucosaminyltransferase activity|cellular response to leukemia inhibitory factor hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGB 276.1424102 272.5884373 279.6963832 1.026075743 0.037137231 0.920508484 1 6.038831009 6.092611356 9488 phosphatidylinositol glycan anchor biosynthesis class B "GO:0000026,GO:0000030,GO:0004376,GO:0005789,GO:0006506,GO:0016021,GO:0016254,GO:0097502" "alpha-1,2-mannosyltransferase activity|mannosyltransferase activity|glycolipid mannosyltransferase activity|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|mannosylation" hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGBOS1 115.1795845 96.75849109 133.6006779 1.380764379 0.465467152 0.298865438 1 3.859359368 5.239694588 101928527 PIGB opposite strand 1 "GO:0005515,GO:0006986,GO:0031307,GO:1900101" protein binding|response to unfolded protein|integral component of mitochondrial outer membrane|regulation of endoplasmic reticulum unfolded protein response PIGC 460.5296396 457.7821084 463.2771708 1.012003664 0.017214513 0.959341849 1 16.51858672 16.43713609 5279 phosphatidylinositol glycan anchor biosynthesis class C "GO:0000506,GO:0003824,GO:0005789,GO:0006506,GO:0016021,GO:0016254,GO:0017176" glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|catalytic activity|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|phosphatidylinositol N-acetylglucosaminyltransferase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGF 410.6489095 409.9230698 411.3747492 1.003541346 0.005100057 0.99558496 1 14.73187934 14.53665897 5281 phosphatidylinositol glycan anchor biosynthesis class F "GO:0004307,GO:0005515,GO:0005789,GO:0006506,GO:0016021,GO:0016254,GO:0051377" ethanolaminephosphotransferase activity|protein binding|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|mannose-ethanolamine phosphotransferase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGG 864.8517774 865.6243504 864.0792044 0.998214993 -0.002577523 0.997073525 1 9.061745906 8.894205248 54872 phosphatidylinositol glycan anchor biosynthesis class G "GO:0005783,GO:0005789,GO:0006506,GO:0016020,GO:0016254,GO:0016780,GO:0030176,GO:0051267" "endoplasmic reticulum|endoplasmic reticulum membrane|GPI anchor biosynthetic process|membrane|preassembly of GPI anchor in ER membrane|phosphotransferase activity, for other substituted phosphate groups|integral component of endoplasmic reticulum membrane|CP2 mannose-ethanolamine phosphotransferase activity" hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGH 356.9185251 374.5489978 339.2880525 0.90585759 -0.142643833 0.638557436 1 13.0818008 11.65195068 5283 phosphatidylinositol glycan anchor biosynthesis class H "GO:0000506,GO:0003824,GO:0005783,GO:0005789,GO:0006464,GO:0006506,GO:0016254,GO:0017176" glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|catalytic activity|endoplasmic reticulum|endoplasmic reticulum membrane|cellular protein modification process|GPI anchor biosynthetic process|preassembly of GPI anchor in ER membrane|phosphatidylinositol N-acetylglucosaminyltransferase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGK 1848.80825 1628.247726 2069.368773 1.27091765 0.345870552 0.144448343 1 18.88645698 23.60147161 10026 phosphatidylinositol glycan anchor biosynthesis class K "GO:0003756,GO:0003923,GO:0005515,GO:0005789,GO:0006508,GO:0016020,GO:0016255,GO:0018215,GO:0034235,GO:0034394,GO:0042765" protein disulfide isomerase activity|GPI-anchor transamidase activity|protein binding|endoplasmic reticulum membrane|proteolysis|membrane|attachment of GPI anchor to protein|protein phosphopantetheinylation|GPI anchor binding|protein localization to cell surface|GPI-anchor transamidase complex hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGL 427.8949965 446.3375557 409.4524373 0.917360487 -0.124439327 0.666630847 1 3.425397615 3.089741879 9487 phosphatidylinositol glycan anchor biosynthesis class L "GO:0000225,GO:0005783,GO:0005789,GO:0006506,GO:0016021,GO:0016254,GO:0016811" "N-acetylglucosaminylphosphatidylinositol deacetylase activity|endoplasmic reticulum|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides" hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGM 382.7407882 396.3976893 369.0838871 0.931094951 -0.102999797 0.731683173 1 3.00582781 2.751878458 93183 phosphatidylinositol glycan anchor biosynthesis class M "GO:0000030,GO:0004376,GO:0005789,GO:0006506,GO:0016021,GO:0016254,GO:0051751,GO:0097502,GO:1990529" "mannosyltransferase activity|glycolipid mannosyltransferase activity|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|alpha-1,4-mannosyltransferase activity|mannosylation|glycosylphosphatidylinositol-mannosyltransferase I complex" hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGN 1229.013571 1253.698729 1204.328413 0.960620271 -0.057961842 0.813343397 1 8.316668358 7.855472439 23556 phosphatidylinositol glycan anchor biosynthesis class N "GO:0005789,GO:0005829,GO:0005886,GO:0006506,GO:0016020,GO:0016021,GO:0016254,GO:0051377" endoplasmic reticulum membrane|cytosol|plasma membrane|GPI anchor biosynthetic process|membrane|integral component of membrane|preassembly of GPI anchor in ER membrane|mannose-ethanolamine phosphotransferase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGO 456.2887261 447.3779695 465.1994827 1.039835473 0.056355278 0.847537408 1 3.772434822 3.857070283 84720 phosphatidylinositol glycan anchor biosynthesis class O "GO:0005789,GO:0006506,GO:0016020,GO:0016021,GO:0051377" endoplasmic reticulum membrane|GPI anchor biosynthetic process|membrane|integral component of membrane|mannose-ethanolamine phosphotransferase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGP 245.9257482 223.6889848 268.1625117 1.198818583 0.261613352 0.441375452 1 12.1319817 14.30067021 51227 phosphatidylinositol glycan anchor biosynthesis class P "GO:0000506,GO:0005515,GO:0005789,GO:0006506,GO:0016021,GO:0016254,GO:0017176" glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|protein binding|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|phosphatidylinositol N-acetylglucosaminyltransferase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGQ 392.7882664 407.842242 377.7342907 0.926177457 -0.110639452 0.709740565 1 7.358279538 6.701031622 9091 phosphatidylinositol glycan anchor biosynthesis class Q "GO:0000506,GO:0005789,GO:0005975,GO:0006506,GO:0016021,GO:0016254,GO:0017176" glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum membrane|carbohydrate metabolic process|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|phosphatidylinositol N-acetylglucosaminyltransferase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGS 946.5387441 1092.434577 800.6429113 0.732897812 -0.448316037 0.069545624 1 23.05307456 16.61282379 94005 phosphatidylinositol glycan anchor biosynthesis class S "GO:0005515,GO:0005789,GO:0016020,GO:0016255,GO:0042765" protein binding|endoplasmic reticulum membrane|membrane|attachment of GPI anchor to protein|GPI-anchor transamidase complex hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGT 3113.219816 3092.110059 3134.329572 1.013653949 0.019565215 0.935578459 1 77.54710094 77.29056141 51604 phosphatidylinositol glycan anchor biosynthesis class T "GO:0005515,GO:0005789,GO:0016020,GO:0016255,GO:0030176,GO:0042765" protein binding|endoplasmic reticulum membrane|membrane|attachment of GPI anchor to protein|integral component of endoplasmic reticulum membrane|GPI-anchor transamidase complex hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGU 664.3878227 624.2483296 704.5273157 1.128601043 0.174535588 0.501534542 1 12.27071309 13.61699968 128869 phosphatidylinositol glycan anchor biosynthesis class U "GO:0005515,GO:0005789,GO:0005886,GO:0006506,GO:0016020,GO:0016255,GO:0034235,GO:0034394,GO:0042765,GO:0046425" protein binding|endoplasmic reticulum membrane|plasma membrane|GPI anchor biosynthetic process|membrane|attachment of GPI anchor to protein|GPI anchor binding|protein localization to cell surface|GPI-anchor transamidase complex|regulation of receptor signaling pathway via JAK-STAT hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGV 359.9359711 340.2153396 379.6566026 1.11593029 0.158246908 0.600510636 1 3.476956604 3.815113957 55650 phosphatidylinositol glycan anchor biosynthesis class V "GO:0000009,GO:0000030,GO:0004376,GO:0005515,GO:0005789,GO:0006506,GO:0016021,GO:0016254,GO:0031501,GO:0097502" "alpha-1,6-mannosyltransferase activity|mannosyltransferase activity|glycolipid mannosyltransferase activity|protein binding|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|mannosyltransferase complex|mannosylation" hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGW 224.9388331 227.8506403 222.0270258 0.974441088 -0.037353128 0.927927547 1 5.33800259 5.114527838 284098 phosphatidylinositol glycan anchor biosynthesis class W "GO:0005789,GO:0006505,GO:0006506,GO:0008374,GO:0016021,GO:0016254,GO:0032216,GO:0072659" endoplasmic reticulum membrane|GPI anchor metabolic process|GPI anchor biosynthetic process|O-acyltransferase activity|integral component of membrane|preassembly of GPI anchor in ER membrane|glucosaminyl-phosphatidylinositol O-acyltransferase activity|protein localization to plasma membrane hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGX 423.8075684 452.5800389 395.0350979 0.87285135 -0.196192117 0.493911161 1 7.811566906 6.704241087 54965 phosphatidylinositol glycan anchor biosynthesis class X "GO:0005789,GO:0016021,GO:0016254" endoplasmic reticulum membrane|integral component of membrane|preassembly of GPI anchor in ER membrane hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGZ 131.5884328 123.809252 139.3676136 1.125663966 0.170776217 0.70073968 1 1.147529043 1.270116706 80235 phosphatidylinositol glycan anchor biosynthesis class Z "GO:0000026,GO:0000030,GO:0005783,GO:0005789,GO:0006506,GO:0016021,GO:0016254,GO:0097502" "alpha-1,2-mannosyltransferase activity|mannosyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|mannosylation" hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIH1D1 816.0020147 743.8959261 888.1081033 1.19386069 0.2556345 0.309170032 1 33.33363422 39.12978813 55011 PIH1 domain containing 1 "GO:0000492,GO:0001164,GO:0001165,GO:0001188,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0006338,GO:0006364,GO:0019901,GO:0030855,GO:0031334,GO:0042393,GO:0048254,GO:0051117,GO:0051219,GO:0051569,GO:0070761,GO:0071169,GO:0071902,GO:0090240,GO:0097255,GO:1900110,GO:1900113,GO:1901838,GO:1902661,GO:1903939,GO:1904263,GO:1990904,GO:2000617,GO:2000619,GO:2001268" box C/D snoRNP assembly|RNA polymerase I core promoter sequence-specific DNA binding|RNA polymerase I cis-regulatory region sequence-specific DNA binding|RNA polymerase I preinitiation complex assembly|protein binding|nucleus|nucleolus|cytoplasm|chromatin remodeling|rRNA processing|protein kinase binding|epithelial cell differentiation|positive regulation of protein-containing complex assembly|histone binding|snoRNA localization|ATPase binding|phosphoprotein binding|regulation of histone H3-K4 methylation|pre-snoRNP complex|establishment of protein localization to chromatin|positive regulation of protein serine/threonine kinase activity|positive regulation of histone H4 acetylation|R2TP complex|negative regulation of histone H3-K9 dimethylation|negative regulation of histone H3-K9 trimethylation|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|positive regulation of glucose mediated signaling pathway|regulation of TORC2 signaling|positive regulation of TORC1 signaling|ribonucleoprotein complex|positive regulation of histone H3-K9 acetylation|negative regulation of histone H4-K16 acetylation|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway PIH1D2 28.3044109 23.9295193 32.6793025 1.365648097 0.449585775 0.56854528 1 0.312625328 0.419791985 120379 PIH1 domain containing 2 "GO:0000492,GO:0005515,GO:0005737,GO:0006364,GO:0031267,GO:0097255,GO:1990904" box C/D snoRNP assembly|protein binding|cytoplasm|rRNA processing|small GTPase binding|R2TP complex|ribonucleoprotein complex PIK3AP1 169.4842816 197.6786377 141.2899255 0.714745544 -0.484498373 0.211394573 1 2.114601238 1.486110551 118788 phosphoinositide-3-kinase adaptor protein 1 "GO:0005102,GO:0005515,GO:0005829,GO:0005886,GO:0014068,GO:0016020,GO:0034134,GO:0034142,GO:0034154,GO:0034162,GO:0036312,GO:0042802,GO:0050727,GO:0051897" signaling receptor binding|protein binding|cytosol|plasma membrane|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway|phosphatidylinositol 3-kinase regulatory subunit binding|identical protein binding|regulation of inflammatory response|positive regulation of protein kinase B signaling "hsa04151,hsa04662" PI3K-Akt signaling pathway|B cell receptor signaling pathway PIK3C2A 1981.523958 2134.929287 1828.118628 0.856290014 -0.223828595 0.344438103 1 13.36977848 11.2568342 5286 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha "GO:0005524,GO:0005654,GO:0005737,GO:0005802,GO:0005829,GO:0005886,GO:0005942,GO:0006661,GO:0006887,GO:0006897,GO:0007173,GO:0008286,GO:0010508,GO:0014065,GO:0014829,GO:0016020,GO:0016303,GO:0016477,GO:0030136,GO:0030276,GO:0031982,GO:0035004,GO:0035005,GO:0035091,GO:0036092,GO:0043231,GO:0046854,GO:0046934,GO:0048008,GO:0048015,GO:0048268,GO:0052742,GO:0052812,GO:0061024,GO:0070062,GO:0090050" "ATP binding|nucleoplasm|cytoplasm|trans-Golgi network|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|phosphatidylinositol biosynthetic process|exocytosis|endocytosis|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of autophagy|phosphatidylinositol 3-kinase signaling|vascular associated smooth muscle contraction|membrane|1-phosphatidylinositol-3-kinase activity|cell migration|clathrin-coated vesicle|clathrin binding|vesicle|phosphatidylinositol 3-kinase activity|1-phosphatidylinositol-4-phosphate 3-kinase activity|phosphatidylinositol binding|phosphatidylinositol-3-phosphate biosynthetic process|intracellular membrane-bounded organelle|phosphatidylinositol phosphorylation|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|platelet-derived growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|clathrin coat assembly|phosphatidylinositol kinase activity|phosphatidylinositol-3,4-bisphosphate 5-kinase activity|membrane organization|extracellular exosome|positive regulation of cell migration involved in sprouting angiogenesis" "hsa00562,hsa04070,hsa05132" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Salmonella infection PIK3C2B 220.7671167 244.4972624 197.036971 0.805886205 -0.311351957 0.376683536 1 1.359913447 1.077596491 5287 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta "GO:0001727,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0005942,GO:0006661,GO:0008150,GO:0009267,GO:0014065,GO:0016020,GO:0016303,GO:0016477,GO:0030139,GO:0035005,GO:0035091,GO:0036092,GO:0043231,GO:0043491,GO:0046854,GO:0048015,GO:0052742,GO:1905037" lipid kinase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|phosphatidylinositol biosynthetic process|biological_process|cellular response to starvation|phosphatidylinositol 3-kinase signaling|membrane|1-phosphatidylinositol-3-kinase activity|cell migration|endocytic vesicle|1-phosphatidylinositol-4-phosphate 3-kinase activity|phosphatidylinositol binding|phosphatidylinositol-3-phosphate biosynthetic process|intracellular membrane-bounded organelle|protein kinase B signaling|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|phosphatidylinositol kinase activity|autophagosome organization "hsa00562,hsa04070,hsa05132" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Salmonella infection PIK3C3 1628.857636 1543.974202 1713.74107 1.109954472 0.150500501 0.527805898 1 16.01536743 17.47886591 5289 phosphatidylinositol 3-kinase catalytic subunit type 3 "GO:0000045,GO:0000407,GO:0005515,GO:0005524,GO:0005737,GO:0005768,GO:0005770,GO:0005777,GO:0005829,GO:0005930,GO:0006497,GO:0006661,GO:0006897,GO:0006914,GO:0007049,GO:0016020,GO:0016236,GO:0016301,GO:0016303,GO:0030242,GO:0030496,GO:0030670,GO:0032465,GO:0034162,GO:0034271,GO:0034272,GO:0035032,GO:0036092,GO:0042149,GO:0044754,GO:0045022,GO:0046854,GO:0048015,GO:0051301,GO:0052742" "autophagosome assembly|phagophore assembly site|protein binding|ATP binding|cytoplasm|endosome|late endosome|peroxisome|cytosol|axoneme|protein lipidation|phosphatidylinositol biosynthetic process|endocytosis|autophagy|cell cycle|membrane|macroautophagy|kinase activity|1-phosphatidylinositol-3-kinase activity|autophagy of peroxisome|midbody|phagocytic vesicle membrane|regulation of cytokinesis|toll-like receptor 9 signaling pathway|phosphatidylinositol 3-kinase complex, class III, type I|phosphatidylinositol 3-kinase complex, class III, type II|phosphatidylinositol 3-kinase complex, class III|phosphatidylinositol-3-phosphate biosynthetic process|cellular response to glucose starvation|autolysosome|early endosome to late endosome transport|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|cell division|phosphatidylinositol kinase activity" "hsa00562,hsa04070,hsa04136,hsa04140,hsa04145,hsa04371,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022,hsa05131,hsa05132,hsa05152,hsa05167" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Autophagy - other|Autophagy - animal|Phagosome|Apelin signaling pathway|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis|Salmonella infection|Tuberculosis|Kaposi sarcoma-associated herpesvirus infection PIK3CA 803.6252598 847.9373144 759.3132052 0.895482711 -0.159262516 0.528564341 1 9.846139257 8.669506128 5290 "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha" "GO:0001525,GO:0001889,GO:0001944,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005942,GO:0005943,GO:0005944,GO:0006006,GO:0006468,GO:0006661,GO:0007173,GO:0007186,GO:0007411,GO:0010468,GO:0010592,GO:0014065,GO:0014068,GO:0014704,GO:0016020,GO:0016242,GO:0016301,GO:0016303,GO:0016310,GO:0016477,GO:0019221,GO:0030027,GO:0030036,GO:0030168,GO:0030295,GO:0030835,GO:0031295,GO:0032008,GO:0032147,GO:0033138,GO:0035004,GO:0035005,GO:0035994,GO:0036092,GO:0038028,GO:0038084,GO:0038095,GO:0038096,GO:0038128,GO:0040014,GO:0043276,GO:0043457,GO:0043491,GO:0043524,GO:0043542,GO:0043560,GO:0044029,GO:0046854,GO:0046934,GO:0048010,GO:0048015,GO:0048471,GO:0050852,GO:0050900,GO:0051897,GO:0052742,GO:0052812,GO:0055119,GO:0060048,GO:0060612,GO:0071333,GO:0071464,GO:0086003,GO:0097009,GO:0106310,GO:0106311,GO:0110053,GO:2000270,GO:2000653,GO:2000811" "angiogenesis|liver development|vasculature development|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|phosphatidylinositol 3-kinase complex, class IA|phosphatidylinositol 3-kinase complex, class IB|glucose metabolic process|protein phosphorylation|phosphatidylinositol biosynthetic process|epidermal growth factor receptor signaling pathway|G protein-coupled receptor signaling pathway|axon guidance|regulation of gene expression|positive regulation of lamellipodium assembly|phosphatidylinositol 3-kinase signaling|positive regulation of phosphatidylinositol 3-kinase signaling|intercalated disc|membrane|negative regulation of macroautophagy|kinase activity|1-phosphatidylinositol-3-kinase activity|phosphorylation|cell migration|cytokine-mediated signaling pathway|lamellipodium|actin cytoskeleton organization|platelet activation|protein kinase activator activity|negative regulation of actin filament depolymerization|T cell costimulation|positive regulation of TOR signaling|activation of protein kinase activity|positive regulation of peptidyl-serine phosphorylation|phosphatidylinositol 3-kinase activity|1-phosphatidylinositol-4-phosphate 3-kinase activity|response to muscle stretch|phosphatidylinositol-3-phosphate biosynthetic process|insulin receptor signaling pathway via phosphatidylinositol 3-kinase|vascular endothelial growth factor signaling pathway|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|ERBB2 signaling pathway|regulation of multicellular organism growth|anoikis|regulation of cellular respiration|protein kinase B signaling|negative regulation of neuron apoptotic process|endothelial cell migration|insulin receptor substrate binding|hypomethylation of CpG island|phosphatidylinositol phosphorylation|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|vascular endothelial growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|T cell receptor signaling pathway|leukocyte migration|positive regulation of protein kinase B signaling|phosphatidylinositol kinase activity|phosphatidylinositol-3,4-bisphosphate 5-kinase activity|relaxation of cardiac muscle|cardiac muscle contraction|adipose tissue development|cellular response to glucose stimulus|cellular response to hydrostatic pressure|cardiac muscle cell contraction|energy homeostasis|protein serine kinase activity|protein threonine kinase activity|regulation of actin filament organization|negative regulation of fibroblast apoptotic process|regulation of genetic imprinting|negative regulation of anoikis" "hsa00562,hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04015,hsa04024,hsa04062,hsa04066,hsa04068,hsa04070,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04670,hsa04722,hsa04725,hsa04750,hsa04810,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04923,hsa04926,hsa04929,hsa04930,hsa04931,hsa04932,hsa04933,hsa04935,hsa04960,hsa04973,hsa05010,hsa05017,hsa05020,hsa05100,hsa05131,hsa05132,hsa05135,hsa05142,hsa05146,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235,hsa05418" "Inositol phosphate metabolism|EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Cholinergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|GnRH secretion|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Carbohydrate digestion and absorption|Alzheimer disease|Spinocerebellar ataxia|Prion disease|Bacterial invasion of epithelial cells|Shigellosis|Salmonella infection|Yersinia infection|Chagas disease|Amoebiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" PIK3CB 1404.958602 1419.124536 1390.792668 0.980035672 -0.029093832 0.906290818 1 12.17230284 11.72967046 5291 "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta" "GO:0000187,GO:0001952,GO:0002931,GO:0003376,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0005942,GO:0006661,GO:0006897,GO:0006914,GO:0006935,GO:0007165,GO:0007169,GO:0007186,GO:0007411,GO:0010508,GO:0010595,GO:0010628,GO:0014065,GO:0014068,GO:0016020,GO:0016301,GO:0016303,GO:0016310,GO:0016477,GO:0019221,GO:0030168,GO:0030496,GO:0033031,GO:0035004,GO:0035005,GO:0035022,GO:0036092,GO:0038095,GO:0038096,GO:0043231,GO:0043407,GO:0046854,GO:0046934,GO:0048010,GO:0048015,GO:0050852,GO:0050900,GO:0051000,GO:0051897,GO:0051898,GO:0052742,GO:0052812,GO:0070527,GO:1900747,GO:1903671,GO:2000369" "activation of MAPK activity|regulation of cell-matrix adhesion|response to ischemia|sphingosine-1-phosphate receptor signaling pathway|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|phosphatidylinositol biosynthetic process|endocytosis|autophagy|chemotaxis|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|G protein-coupled receptor signaling pathway|axon guidance|positive regulation of autophagy|positive regulation of endothelial cell migration|positive regulation of gene expression|phosphatidylinositol 3-kinase signaling|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|kinase activity|1-phosphatidylinositol-3-kinase activity|phosphorylation|cell migration|cytokine-mediated signaling pathway|platelet activation|midbody|positive regulation of neutrophil apoptotic process|phosphatidylinositol 3-kinase activity|1-phosphatidylinositol-4-phosphate 3-kinase activity|positive regulation of Rac protein signal transduction|phosphatidylinositol-3-phosphate biosynthetic process|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|intracellular membrane-bounded organelle|negative regulation of MAP kinase activity|phosphatidylinositol phosphorylation|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|vascular endothelial growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|T cell receptor signaling pathway|leukocyte migration|positive regulation of nitric-oxide synthase activity|positive regulation of protein kinase B signaling|negative regulation of protein kinase B signaling|phosphatidylinositol kinase activity|phosphatidylinositol-3,4-bisphosphate 5-kinase activity|platelet aggregation|negative regulation of vascular endothelial growth factor signaling pathway|negative regulation of sprouting angiogenesis|regulation of clathrin-dependent endocytosis" "hsa00562,hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04015,hsa04024,hsa04062,hsa04066,hsa04068,hsa04070,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04670,hsa04722,hsa04725,hsa04750,hsa04810,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04923,hsa04926,hsa04929,hsa04930,hsa04931,hsa04932,hsa04933,hsa04935,hsa04960,hsa04973,hsa05010,hsa05017,hsa05020,hsa05100,hsa05131,hsa05132,hsa05135,hsa05142,hsa05146,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235,hsa05418" "Inositol phosphate metabolism|EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Cholinergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|GnRH secretion|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Carbohydrate digestion and absorption|Alzheimer disease|Spinocerebellar ataxia|Prion disease|Bacterial invasion of epithelial cells|Shigellosis|Salmonella infection|Yersinia infection|Chagas disease|Amoebiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" PIK3CD 3376.002965 3720.520044 3031.485885 0.814801654 -0.295479186 0.212874518 1 32.35940625 25.9252901 5293 "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta" "GO:0001779,GO:0001816,GO:0001938,GO:0002250,GO:0002551,GO:0002679,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005942,GO:0006468,GO:0006661,GO:0006954,GO:0007165,GO:0007411,GO:0010595,GO:0010628,GO:0010818,GO:0014065,GO:0014068,GO:0016020,GO:0016301,GO:0016303,GO:0016310,GO:0016477,GO:0019221,GO:0030101,GO:0030217,GO:0030335,GO:0030593,GO:0033031,GO:0035004,GO:0035005,GO:0035747,GO:0035754,GO:0036092,GO:0038089,GO:0042110,GO:0042113,GO:0043303,GO:0045087,GO:0045766,GO:0046854,GO:0046934,GO:0048015,GO:0050852,GO:0050853,GO:0051897,GO:0052742,GO:0052812,GO:0060374,GO:0072672,GO:1905278" "natural killer cell differentiation|cytokine production|positive regulation of endothelial cell proliferation|adaptive immune response|mast cell chemotaxis|respiratory burst involved in defense response|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|protein phosphorylation|phosphatidylinositol biosynthetic process|inflammatory response|signal transduction|axon guidance|positive regulation of endothelial cell migration|positive regulation of gene expression|T cell chemotaxis|phosphatidylinositol 3-kinase signaling|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|kinase activity|1-phosphatidylinositol-3-kinase activity|phosphorylation|cell migration|cytokine-mediated signaling pathway|natural killer cell activation|T cell differentiation|positive regulation of cell migration|neutrophil chemotaxis|positive regulation of neutrophil apoptotic process|phosphatidylinositol 3-kinase activity|1-phosphatidylinositol-4-phosphate 3-kinase activity|natural killer cell chemotaxis|B cell chemotaxis|phosphatidylinositol-3-phosphate biosynthetic process|positive regulation of cell migration by vascular endothelial growth factor signaling pathway|T cell activation|B cell activation|mast cell degranulation|innate immune response|positive regulation of angiogenesis|phosphatidylinositol phosphorylation|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|phosphatidylinositol-mediated signaling|T cell receptor signaling pathway|B cell receptor signaling pathway|positive regulation of protein kinase B signaling|phosphatidylinositol kinase activity|phosphatidylinositol-3,4-bisphosphate 5-kinase activity|mast cell differentiation|neutrophil extravasation|positive regulation of epithelial tube formation" "hsa00562,hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04015,hsa04024,hsa04062,hsa04066,hsa04068,hsa04070,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04670,hsa04722,hsa04725,hsa04750,hsa04810,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04923,hsa04926,hsa04929,hsa04930,hsa04931,hsa04932,hsa04933,hsa04935,hsa04960,hsa04973,hsa05010,hsa05017,hsa05020,hsa05100,hsa05131,hsa05132,hsa05135,hsa05142,hsa05146,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235,hsa05418" "Inositol phosphate metabolism|EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Cholinergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|GnRH secretion|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Carbohydrate digestion and absorption|Alzheimer disease|Spinocerebellar ataxia|Prion disease|Bacterial invasion of epithelial cells|Shigellosis|Salmonella infection|Yersinia infection|Chagas disease|Amoebiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" PIK3CG 184.3771685 210.1636043 158.5907327 0.754606076 -0.406204378 0.279983001 1 1.385552229 1.028050332 5294 "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma" "GO:0001525,GO:0001816,GO:0002250,GO:0002407,GO:0002675,GO:0002679,GO:0003376,GO:0004672,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005942,GO:0005943,GO:0005944,GO:0006468,GO:0006661,GO:0006897,GO:0006954,GO:0007186,GO:0007204,GO:0010595,GO:0010818,GO:0010897,GO:0014065,GO:0014068,GO:0016020,GO:0016301,GO:0016303,GO:0016310,GO:0016477,GO:0030168,GO:0030593,GO:0032252,GO:0033628,GO:0035004,GO:0035005,GO:0035022,GO:0035747,GO:0036092,GO:0042098,GO:0042110,GO:0042802,GO:0043303,GO:0043406,GO:0045087,GO:0046854,GO:0046875,GO:0046934,GO:0048015,GO:0051897,GO:0052742,GO:0052812,GO:0055118,GO:0070527,GO:0071320,GO:0072672,GO:0097284,GO:0106310,GO:0106311,GO:1903169,GO:2000270" "angiogenesis|cytokine production|adaptive immune response|dendritic cell chemotaxis|positive regulation of acute inflammatory response|respiratory burst involved in defense response|sphingosine-1-phosphate receptor signaling pathway|protein kinase activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|phosphatidylinositol 3-kinase complex, class IA|phosphatidylinositol 3-kinase complex, class IB|protein phosphorylation|phosphatidylinositol biosynthetic process|endocytosis|inflammatory response|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|positive regulation of endothelial cell migration|T cell chemotaxis|negative regulation of triglyceride catabolic process|phosphatidylinositol 3-kinase signaling|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|kinase activity|1-phosphatidylinositol-3-kinase activity|phosphorylation|cell migration|platelet activation|neutrophil chemotaxis|secretory granule localization|regulation of cell adhesion mediated by integrin|phosphatidylinositol 3-kinase activity|1-phosphatidylinositol-4-phosphate 3-kinase activity|positive regulation of Rac protein signal transduction|natural killer cell chemotaxis|phosphatidylinositol-3-phosphate biosynthetic process|T cell proliferation|T cell activation|identical protein binding|mast cell degranulation|positive regulation of MAP kinase activity|innate immune response|phosphatidylinositol phosphorylation|ephrin receptor binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase B signaling|phosphatidylinositol kinase activity|phosphatidylinositol-3,4-bisphosphate 5-kinase activity|negative regulation of cardiac muscle contraction|platelet aggregation|cellular response to cAMP|neutrophil extravasation|hepatocyte apoptotic process|protein serine kinase activity|protein threonine kinase activity|regulation of calcium ion transmembrane transport|negative regulation of fibroblast apoptotic process" "hsa00562,hsa04022,hsa04062,hsa04072,hsa04151,hsa04261,hsa04371,hsa04611,hsa04725,hsa04921,hsa05132,hsa05145,hsa05167" Inositol phosphate metabolism|cGMP-PKG signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Adrenergic signaling in cardiomyocytes|Apelin signaling pathway|Platelet activation|Cholinergic synapse|Oxytocin signaling pathway|Salmonella infection|Toxoplasmosis|Kaposi sarcoma-associated herpesvirus infection PIK3IP1 148.7502315 170.6278768 126.8725862 0.74356306 -0.427472995 0.295238097 1 3.751996779 2.743161908 113791 phosphoinositide-3-kinase interacting protein 1 "GO:0004252,GO:0005515,GO:0005886,GO:0006508,GO:0014067,GO:0016021,GO:0036313,GO:0043553" serine-type endopeptidase activity|protein binding|plasma membrane|proteolysis|negative regulation of phosphatidylinositol 3-kinase signaling|integral component of membrane|phosphatidylinositol 3-kinase catalytic subunit binding|negative regulation of phosphatidylinositol 3-kinase activity PIK3R1 540.5427433 564.9447383 516.1407484 0.913612807 -0.13034522 0.631501106 1 3.128573452 2.810474915 5295 phosphoinositide-3-kinase regulatory subunit 1 "GO:0001678,GO:0001784,GO:0001953,GO:0005068,GO:0005158,GO:0005159,GO:0005168,GO:0005515,GO:0005634,GO:0005737,GO:0005801,GO:0005829,GO:0005886,GO:0005911,GO:0005942,GO:0005943,GO:0006468,GO:0006606,GO:0006661,GO:0007173,GO:0007186,GO:0007411,GO:0008134,GO:0008286,GO:0008625,GO:0008630,GO:0010592,GO:0014065,GO:0014068,GO:0016020,GO:0016032,GO:0019221,GO:0019903,GO:0030168,GO:0030183,GO:0030335,GO:0031295,GO:0032760,GO:0032869,GO:0033120,GO:0034446,GO:0034644,GO:0034976,GO:0035014,GO:0036312,GO:0038095,GO:0038096,GO:0038128,GO:0042307,GO:0043066,GO:0043125,GO:0043548,GO:0043551,GO:0043559,GO:0043560,GO:0045671,GO:0045944,GO:0046326,GO:0046626,GO:0046854,GO:0046935,GO:0046982,GO:0048009,GO:0048010,GO:0048015,GO:0048471,GO:0050821,GO:0050852,GO:0050900,GO:0051491,GO:0051497,GO:0051897,GO:0060396,GO:0120183,GO:1900103,GO:1903078,GO:1990578" "cellular glucose homeostasis|phosphotyrosine residue binding|negative regulation of cell-matrix adhesion|transmembrane receptor protein tyrosine kinase adaptor activity|insulin receptor binding|insulin-like growth factor receptor binding|neurotrophin TRKA receptor binding|protein binding|nucleus|cytoplasm|cis-Golgi network|cytosol|plasma membrane|cell-cell junction|phosphatidylinositol 3-kinase complex|phosphatidylinositol 3-kinase complex, class IA|protein phosphorylation|protein import into nucleus|phosphatidylinositol biosynthetic process|epidermal growth factor receptor signaling pathway|G protein-coupled receptor signaling pathway|axon guidance|transcription factor binding|insulin receptor signaling pathway|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of lamellipodium assembly|phosphatidylinositol 3-kinase signaling|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|viral process|cytokine-mediated signaling pathway|protein phosphatase binding|platelet activation|B cell differentiation|positive regulation of cell migration|T cell costimulation|positive regulation of tumor necrosis factor production|cellular response to insulin stimulus|positive regulation of RNA splicing|substrate adhesion-dependent cell spreading|cellular response to UV|response to endoplasmic reticulum stress|phosphatidylinositol 3-kinase regulator activity|phosphatidylinositol 3-kinase regulatory subunit binding|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|ERBB2 signaling pathway|positive regulation of protein import into nucleus|negative regulation of apoptotic process|ErbB-3 class receptor binding|phosphatidylinositol 3-kinase binding|regulation of phosphatidylinositol 3-kinase activity|insulin binding|insulin receptor substrate binding|negative regulation of osteoclast differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of glucose import|regulation of insulin receptor signaling pathway|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity|protein heterodimerization activity|insulin-like growth factor receptor signaling pathway|vascular endothelial growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|protein stabilization|T cell receptor signaling pathway|leukocyte migration|positive regulation of filopodium assembly|negative regulation of stress fiber assembly|positive regulation of protein kinase B signaling|growth hormone receptor signaling pathway|positive regulation of focal adhesion disassembly|positive regulation of endoplasmic reticulum unfolded protein response|positive regulation of protein localization to plasma membrane|perinuclear endoplasmic reticulum membrane" "hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04015,hsa04024,hsa04062,hsa04066,hsa04068,hsa04070,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04670,hsa04722,hsa04725,hsa04750,hsa04810,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04923,hsa04926,hsa04929,hsa04930,hsa04931,hsa04932,hsa04933,hsa04935,hsa04960,hsa04973,hsa05010,hsa05017,hsa05020,hsa05100,hsa05131,hsa05135,hsa05142,hsa05146,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235,hsa05418" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Cholinergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|GnRH secretion|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Carbohydrate digestion and absorption|Alzheimer disease|Spinocerebellar ataxia|Prion disease|Bacterial invasion of epithelial cells|Shigellosis|Yersinia infection|Chagas disease|Amoebiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" PIK3R2 1430.097726 1347.335978 1512.859475 1.122852428 0.167168333 0.485642189 1 18.06654393 19.94660294 5296 phosphoinositide-3-kinase regulatory subunit 2 "GO:0001678,GO:0001784,GO:0005515,GO:0005634,GO:0005829,GO:0005942,GO:0006661,GO:0008286,GO:0010506,GO:0014065,GO:0015031,GO:0019903,GO:0030971,GO:0032869,GO:0034976,GO:0038095,GO:0038096,GO:0042307,GO:0043409,GO:0043551,GO:0045944,GO:0046854,GO:0046935,GO:0046982,GO:0048010,GO:0048015,GO:0050852,GO:0050900,GO:0051056,GO:0051897" cellular glucose homeostasis|phosphotyrosine residue binding|protein binding|nucleus|cytosol|phosphatidylinositol 3-kinase complex|phosphatidylinositol biosynthetic process|insulin receptor signaling pathway|regulation of autophagy|phosphatidylinositol 3-kinase signaling|protein transport|protein phosphatase binding|receptor tyrosine kinase binding|cellular response to insulin stimulus|response to endoplasmic reticulum stress|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of protein import into nucleus|negative regulation of MAPK cascade|regulation of phosphatidylinositol 3-kinase activity|positive regulation of transcription by RNA polymerase II|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity|protein heterodimerization activity|vascular endothelial growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|T cell receptor signaling pathway|leukocyte migration|regulation of small GTPase mediated signal transduction|positive regulation of protein kinase B signaling "hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04015,hsa04024,hsa04062,hsa04066,hsa04068,hsa04070,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04670,hsa04722,hsa04725,hsa04750,hsa04810,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04923,hsa04926,hsa04929,hsa04930,hsa04931,hsa04932,hsa04933,hsa04935,hsa04960,hsa04973,hsa05010,hsa05017,hsa05020,hsa05100,hsa05131,hsa05135,hsa05142,hsa05146,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235,hsa05418" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Cholinergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|GnRH secretion|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Carbohydrate digestion and absorption|Alzheimer disease|Spinocerebellar ataxia|Prion disease|Bacterial invasion of epithelial cells|Shigellosis|Yersinia infection|Chagas disease|Amoebiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" PIK3R3 7.084752362 9.363724944 4.80577978 0.513233762 -0.962312016 0.521952192 1 0.081774634 0.0412672 8503 phosphoinositide-3-kinase regulatory subunit 3 "GO:0001784,GO:0001934,GO:0002042,GO:0005515,GO:0005829,GO:0005942,GO:0006661,GO:0008286,GO:0010628,GO:0016303,GO:0030335,GO:0036092,GO:0043491,GO:0043551,GO:0046854,GO:0046935" phosphotyrosine residue binding|positive regulation of protein phosphorylation|cell migration involved in sprouting angiogenesis|protein binding|cytosol|phosphatidylinositol 3-kinase complex|phosphatidylinositol biosynthetic process|insulin receptor signaling pathway|positive regulation of gene expression|1-phosphatidylinositol-3-kinase activity|positive regulation of cell migration|phosphatidylinositol-3-phosphate biosynthetic process|protein kinase B signaling|regulation of phosphatidylinositol 3-kinase activity|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity "hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04015,hsa04024,hsa04062,hsa04066,hsa04068,hsa04070,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04670,hsa04722,hsa04725,hsa04750,hsa04810,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04923,hsa04926,hsa04929,hsa04930,hsa04931,hsa04932,hsa04933,hsa04935,hsa04960,hsa04973,hsa05010,hsa05017,hsa05020,hsa05100,hsa05131,hsa05135,hsa05142,hsa05146,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235,hsa05418" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Cholinergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|GnRH secretion|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Carbohydrate digestion and absorption|Alzheimer disease|Spinocerebellar ataxia|Prion disease|Bacterial invasion of epithelial cells|Shigellosis|Yersinia infection|Chagas disease|Amoebiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Fluid shear stress and atherosclerosis" PIK3R4 1047.995418 1056.020091 1039.970744 0.984802044 -0.022094338 0.932188563 1 11.2356163 10.87970249 30849 phosphoinositide-3-kinase regulatory subunit 4 "GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005770,GO:0005776,GO:0005829,GO:0005930,GO:0006468,GO:0006623,GO:0006661,GO:0015630,GO:0016020,GO:0016236,GO:0030242,GO:0030670,GO:0032465,GO:0032801,GO:0034162,GO:0034271,GO:0034272,GO:0035032,GO:0042149,GO:0043231,GO:0043552,GO:0045324,GO:0071561,GO:0106310,GO:0106311" "protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|late endosome|autophagosome|cytosol|axoneme|protein phosphorylation|protein targeting to vacuole|phosphatidylinositol biosynthetic process|microtubule cytoskeleton|membrane|macroautophagy|autophagy of peroxisome|phagocytic vesicle membrane|regulation of cytokinesis|receptor catabolic process|toll-like receptor 9 signaling pathway|phosphatidylinositol 3-kinase complex, class III, type I|phosphatidylinositol 3-kinase complex, class III, type II|phosphatidylinositol 3-kinase complex, class III|cellular response to glucose starvation|intracellular membrane-bounded organelle|positive regulation of phosphatidylinositol 3-kinase activity|late endosome to vacuole transport|nucleus-vacuole junction|protein serine kinase activity|protein threonine kinase activity" "hsa04136,hsa04140,hsa04371,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022,hsa05131" Autophagy - other|Autophagy - animal|Apelin signaling pathway|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis PIKFYVE 1591.010862 1547.095443 1634.926281 1.056771441 0.079663384 0.739790019 1 8.238439471 8.560461962 200576 "phosphoinositide kinase, FYVE-type zinc finger containing" "GO:0000139,GO:0000285,GO:0004674,GO:0005515,GO:0005524,GO:0005829,GO:0005911,GO:0006612,GO:0006661,GO:0006898,GO:0008270,GO:0010008,GO:0016308,GO:0019065,GO:0019886,GO:0030593,GO:0030670,GO:0031901,GO:0031902,GO:0032288,GO:0032438,GO:0034504,GO:0035556,GO:0036092,GO:0036289,GO:0042147,GO:0043231,GO:0043813,GO:0045121,GO:0046854,GO:0048471,GO:0052810,GO:0090382,GO:0090385,GO:0106310,GO:0106311,GO:1903100,GO:1903426,GO:1904562,GO:2000785" "Golgi membrane|1-phosphatidylinositol-3-phosphate 5-kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|cytosol|cell-cell junction|protein targeting to membrane|phosphatidylinositol biosynthetic process|receptor-mediated endocytosis|zinc ion binding|endosome membrane|1-phosphatidylinositol-4-phosphate 5-kinase activity|receptor-mediated endocytosis of virus by host cell|antigen processing and presentation of exogenous peptide antigen via MHC class II|neutrophil chemotaxis|phagocytic vesicle membrane|early endosome membrane|late endosome membrane|myelin assembly|melanosome organization|protein localization to nucleus|intracellular signal transduction|phosphatidylinositol-3-phosphate biosynthetic process|peptidyl-serine autophosphorylation|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|membrane raft|phosphatidylinositol phosphorylation|perinuclear region of cytoplasm|1-phosphatidylinositol-5-kinase activity|phagosome maturation|phagosome-lysosome fusion|protein serine kinase activity|protein threonine kinase activity|1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process|regulation of reactive oxygen species biosynthetic process|phosphatidylinositol 5-phosphate metabolic process|regulation of autophagosome assembly" "hsa00562,hsa04070,hsa04145,hsa04810" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Phagosome|Regulation of actin cytoskeleton PILRA 11.04826308 12.48496659 9.61155956 0.769850643 -0.377349516 0.799003187 1 0.517313448 0.391589848 29992 paired immunoglobin like type 2 receptor alpha "GO:0005515,GO:0005886,GO:0007165,GO:0016021,GO:0016032,GO:0042288,GO:0050776,GO:0070062" protein binding|plasma membrane|signal transduction|integral component of membrane|viral process|MHC class I protein binding|regulation of immune response|extracellular exosome hsa05168 Herpes simplex virus 1 infection PILRB 341.2179677 378.7106533 303.7252821 0.801998252 -0.318329002 0.293781277 1 13.51912477 10.66088299 29990 paired immunoglobin like type 2 receptor beta "GO:0005515,GO:0005886,GO:0005887,GO:0007169,GO:0007171,GO:0042288,GO:0050776" protein binding|plasma membrane|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|activation of transmembrane receptor protein tyrosine kinase activity|MHC class I protein binding|regulation of immune response hsa05168 Herpes simplex virus 1 infection PIM1 759.610845 752.2192372 767.0024529 1.019652802 0.028077989 0.917133607 1 14.85185282 14.89032347 5292 "Pim-1 proto-oncogene, serine/threonine kinase" "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0006915,GO:0007049,GO:0007275,GO:0008134,GO:0019221,GO:0022898,GO:0030145,GO:0030212,GO:0043024,GO:0043066,GO:0043433,GO:0045893,GO:0046777,GO:0050821,GO:0060045,GO:0070561,GO:0090336,GO:0106310,GO:0106311,GO:1902033,GO:1905062,GO:1990748" "protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|protein phosphorylation|apoptotic process|cell cycle|multicellular organism development|transcription factor binding|cytokine-mediated signaling pathway|regulation of transmembrane transporter activity|manganese ion binding|hyaluronan metabolic process|ribosomal small subunit binding|negative regulation of apoptotic process|negative regulation of DNA-binding transcription factor activity|positive regulation of transcription, DNA-templated|protein autophosphorylation|protein stabilization|positive regulation of cardiac muscle cell proliferation|vitamin D receptor signaling pathway|positive regulation of brown fat cell differentiation|protein serine kinase activity|protein threonine kinase activity|regulation of hematopoietic stem cell proliferation|positive regulation of cardioblast proliferation|cellular detoxification" "hsa04630,hsa04933,hsa05200,hsa05206,hsa05221" JAK-STAT signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Pathways in cancer|MicroRNAs in cancer|Acute myeloid leukemia PIM2 342.516277 337.094098 347.9384561 1.032170122 0.045680774 0.889573494 1 8.669924075 8.799089925 11040 "Pim-2 proto-oncogene, serine/threonine kinase" "GO:0000082,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0006915,GO:0007346,GO:0008285,GO:0009615,GO:0010508,GO:0043066,GO:0043123,GO:0045893,GO:0046777,GO:0050821,GO:0106310,GO:0106311" "G1/S transition of mitotic cell cycle|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|protein phosphorylation|apoptotic process|regulation of mitotic cell cycle|negative regulation of cell population proliferation|response to virus|positive regulation of autophagy|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription, DNA-templated|protein autophosphorylation|protein stabilization|protein serine kinase activity|protein threonine kinase activity" "hsa05200,hsa05221" Pathways in cancer|Acute myeloid leukemia PIM3 1796.542294 1934.129408 1658.95518 0.857727086 -0.221409416 0.350648003 1 49.10605695 41.41478073 415116 "Pim-3 proto-oncogene, serine/threonine kinase" "GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0006915,GO:0007049,GO:0007346,GO:0043066,GO:0046777,GO:0061179,GO:0106310,GO:0106311" protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytosol|protein phosphorylation|apoptotic process|cell cycle|regulation of mitotic cell cycle|negative regulation of apoptotic process|protein autophosphorylation|negative regulation of insulin secretion involved in cellular response to glucose stimulus|protein serine kinase activity|protein threonine kinase activity PIMREG 674.9202948 724.1280623 625.7125274 0.86409098 -0.210744873 0.414787233 1 16.9422989 14.39471232 54478 PICALM interacting mitotic regulator "GO:0005515,GO:0005654,GO:0005730,GO:0007049,GO:0051301" protein binding|nucleoplasm|nucleolus|cell cycle|cell division PIN1 816.71092 674.188196 959.2336441 1.42279804 0.508730893 0.042775714 1 31.95398305 44.70328492 5300 "peptidylprolyl cis/trans isomerase, NIMA-interacting 1" "GO:0000413,GO:0001666,GO:0001932,GO:0001934,GO:0003755,GO:0003774,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0007049,GO:0007088,GO:0008013,GO:0010468,GO:0016607,GO:0016859,GO:0030182,GO:0030496,GO:0030512,GO:0031434,GO:0031647,GO:0032091,GO:0032092,GO:0032465,GO:0032480,GO:0032794,GO:0035307,GO:0036064,GO:0042177,GO:0043005,GO:0043524,GO:0043525,GO:0043547,GO:0045944,GO:0046785,GO:0048156,GO:0050808,GO:0050815,GO:0050816,GO:0050821,GO:0051219,GO:0051443,GO:0060393,GO:0061051,GO:0070373,GO:0090263,GO:0098978,GO:0099524,GO:1900180,GO:1901796,GO:1902430,GO:2000146" protein peptidyl-prolyl isomerization|response to hypoxia|regulation of protein phosphorylation|positive regulation of protein phosphorylation|peptidyl-prolyl cis-trans isomerase activity|motor activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|cell cycle|regulation of mitotic nuclear division|beta-catenin binding|regulation of gene expression|nuclear speck|cis-trans isomerase activity|neuron differentiation|midbody|negative regulation of transforming growth factor beta receptor signaling pathway|mitogen-activated protein kinase kinase binding|regulation of protein stability|negative regulation of protein binding|positive regulation of protein binding|regulation of cytokinesis|negative regulation of type I interferon production|GTPase activating protein binding|positive regulation of protein dephosphorylation|ciliary basal body|negative regulation of protein catabolic process|neuron projection|negative regulation of neuron apoptotic process|positive regulation of neuron apoptotic process|positive regulation of GTPase activity|positive regulation of transcription by RNA polymerase II|microtubule polymerization|tau protein binding|synapse organization|phosphoserine residue binding|phosphothreonine residue binding|protein stabilization|phosphoprotein binding|positive regulation of ubiquitin-protein transferase activity|regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of cell growth involved in cardiac muscle cell development|negative regulation of ERK1 and ERK2 cascade|positive regulation of canonical Wnt signaling pathway|glutamatergic synapse|postsynaptic cytosol|regulation of protein localization to nucleus|regulation of signal transduction by p53 class mediator|negative regulation of amyloid-beta formation|negative regulation of cell motility hsa04622 RIG-I-like receptor signaling pathway PIN4 357.6670594 305.8816815 409.4524373 1.338597445 0.420722165 0.158860234 1 6.33217345 8.33439295 5303 "peptidylprolyl cis/trans isomerase, NIMA-interacting 4" "GO:0000413,GO:0003677,GO:0003723,GO:0003755,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0005759,GO:0005819,GO:0006364" protein peptidyl-prolyl isomerization|DNA binding|RNA binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|nucleoplasm|chromosome|nucleolus|mitochondrial matrix|spindle|rRNA processing PINK1 2094.966741 1870.664161 2319.269322 1.239810635 0.310119785 0.189828575 1 37.57392102 45.80501758 65018 PTEN induced kinase 1 "GO:0000287,GO:0000422,GO:0000785,GO:0001934,GO:0002020,GO:0002082,GO:0002931,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005741,GO:0005743,GO:0005758,GO:0005783,GO:0005829,GO:0005856,GO:0006468,GO:0006511,GO:0006979,GO:0007005,GO:0010310,GO:0010629,GO:0010821,GO:0010857,GO:0010952,GO:0016020,GO:0016236,GO:0016239,GO:0016242,GO:0016301,GO:0016504,GO:0016567,GO:0018105,GO:0022904,GO:0030424,GO:0030426,GO:0031307,GO:0031396,GO:0031398,GO:0031625,GO:0032148,GO:0032226,GO:0033138,GO:0033603,GO:0034599,GO:0035307,GO:0035556,GO:0036289,GO:0038203,GO:0042981,GO:0043123,GO:0043254,GO:0043422,GO:0043524,GO:0044297,GO:0044877,GO:0045727,GO:0046329,GO:0048471,GO:0050821,GO:0051091,GO:0051443,GO:0051881,GO:0051897,GO:0055131,GO:0061136,GO:0071456,GO:0072655,GO:0072656,GO:0090141,GO:0090200,GO:0090258,GO:0097237,GO:0097413,GO:0097449,GO:0098779,GO:0099074,GO:0106310,GO:0106311,GO:1900407,GO:1901727,GO:1902803,GO:1902902,GO:1902958,GO:1903146,GO:1903147,GO:1903202,GO:1903204,GO:1903214,GO:1903298,GO:1903384,GO:1903751,GO:1903852,GO:1903955,GO:1904544,GO:1904783,GO:1904841,GO:1904881,GO:2000377,GO:2000378,GO:2001171,GO:2001243" "magnesium ion binding|autophagy of mitochondrion|chromatin|positive regulation of protein phosphorylation|protease binding|regulation of oxidative phosphorylation|response to ischemia|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial intermembrane space|endoplasmic reticulum|cytosol|cytoskeleton|protein phosphorylation|ubiquitin-dependent protein catabolic process|response to oxidative stress|mitochondrion organization|regulation of hydrogen peroxide metabolic process|negative regulation of gene expression|regulation of mitochondrion organization|calcium-dependent protein kinase activity|positive regulation of peptidase activity|membrane|macroautophagy|positive regulation of macroautophagy|negative regulation of macroautophagy|kinase activity|peptidase activator activity|protein ubiquitination|peptidyl-serine phosphorylation|respiratory electron transport chain|axon|growth cone|integral component of mitochondrial outer membrane|regulation of protein ubiquitination|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|activation of protein kinase B activity|positive regulation of synaptic transmission, dopaminergic|positive regulation of peptidyl-serine phosphorylation|positive regulation of dopamine secretion|cellular response to oxidative stress|positive regulation of protein dephosphorylation|intracellular signal transduction|peptidyl-serine autophosphorylation|TORC2 signaling|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|regulation of protein-containing complex assembly|protein kinase B binding|negative regulation of neuron apoptotic process|cell body|protein-containing complex binding|positive regulation of translation|negative regulation of JNK cascade|perinuclear region of cytoplasm|protein stabilization|positive regulation of DNA-binding transcription factor activity|positive regulation of ubiquitin-protein transferase activity|regulation of mitochondrial membrane potential|positive regulation of protein kinase B signaling|C3HC4-type RING finger domain binding|regulation of proteasomal protein catabolic process|cellular response to hypoxia|establishment of protein localization to mitochondrion|maintenance of protein location in mitochondrion|positive regulation of mitochondrial fission|positive regulation of release of cytochrome c from mitochondria|negative regulation of mitochondrial fission|cellular response to toxic substance|Lewy body|astrocyte projection|positive regulation of mitophagy in response to mitochondrial depolarization|mitochondrion to lysosome transport|protein serine kinase activity|protein threonine kinase activity|regulation of cellular response to oxidative stress|positive regulation of histone deacetylase activity|regulation of synaptic vesicle transport|negative regulation of autophagosome assembly|positive regulation of mitochondrial electron transport, NADH to ubiquinone|regulation of autophagy of mitochondrion|negative regulation of autophagy of mitochondrion|negative regulation of oxidative stress-induced cell death|negative regulation of oxidative stress-induced neuron death|regulation of protein targeting to mitochondrion|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway|negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway|negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|positive regulation of cristae formation|positive regulation of protein targeting to mitochondrion|positive regulation of free ubiquitin chain polymerization|positive regulation of NMDA glutamate receptor activity|TORC2 complex binding|cellular response to hydrogen sulfide|regulation of reactive oxygen species metabolic process|negative regulation of reactive oxygen species metabolic process|positive regulation of ATP biosynthetic process|negative regulation of intrinsic apoptotic signaling pathway" "hsa04137,hsa05012,hsa05014,hsa05022" Mitophagy - animal|Parkinson disease|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases PINLYP 96.52133169 86.35435226 106.6883111 1.235471153 0.305061325 0.529394307 1 3.238631811 3.934280908 390940 phospholipase A2 inhibitor and LY6/PLAUR domain containing "GO:0004859,GO:0005576,GO:0043086" phospholipase inhibitor activity|extracellular region|negative regulation of catalytic activity PINX1 204.4771552 220.5677431 188.3865674 0.854098449 -0.22752572 0.533777774 1 7.61403303 6.394312667 54984 PIN2 (TERF1) interacting telomerase inhibitor 1 "GO:0000228,GO:0000776,GO:0000777,GO:0000781,GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0005819,GO:0007004,GO:0007080,GO:0008285,GO:0010521,GO:0010972,GO:0031397,GO:0031647,GO:0032211,GO:0044877,GO:0051972,GO:0051974,GO:0070034,GO:0070198,GO:1902570,GO:1904357,GO:1904744,GO:1904751" "nuclear chromosome|kinetochore|condensed chromosome kinetochore|chromosome, telomeric region|protein binding|nucleoplasm|nucleolus|mitochondrion|spindle|telomere maintenance via telomerase|mitotic metaphase plate congression|negative regulation of cell population proliferation|telomerase inhibitor activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of protein ubiquitination|regulation of protein stability|negative regulation of telomere maintenance via telomerase|protein-containing complex binding|regulation of telomerase activity|negative regulation of telomerase activity|telomerase RNA binding|protein localization to chromosome, telomeric region|protein localization to nucleolus|negative regulation of telomere maintenance via telomere lengthening|positive regulation of telomeric DNA binding|positive regulation of protein localization to nucleolus" PIP4K2A 969.2605016 957.180772 981.3402311 1.025240226 0.03596199 0.888173448 1 11.61768901 11.71160896 5305 phosphatidylinositol-5-phosphate 4-kinase type 2 alpha "GO:0005515,GO:0005524,GO:0005654,GO:0005764,GO:0005776,GO:0005829,GO:0005886,GO:0006644,GO:0006661,GO:0010506,GO:0014066,GO:0016308,GO:0016309,GO:0035855,GO:0042803,GO:0046627,GO:0046854,GO:0061909,GO:0090119,GO:0090217,GO:1902635,GO:2000786" "protein binding|ATP binding|nucleoplasm|lysosome|autophagosome|cytosol|plasma membrane|phospholipid metabolic process|phosphatidylinositol biosynthetic process|regulation of autophagy|regulation of phosphatidylinositol 3-kinase signaling|1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|megakaryocyte development|protein homodimerization activity|negative regulation of insulin receptor signaling pathway|phosphatidylinositol phosphorylation|autophagosome-lysosome fusion|vesicle-mediated cholesterol transport|negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process|positive regulation of autophagosome assembly" "hsa00562,hsa04070,hsa04810" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Regulation of actin cytoskeleton PIP4K2B 2199.190569 2222.324053 2176.057084 0.979180818 -0.030352799 0.899726376 1 21.98356817 21.16568167 8396 phosphatidylinositol-5-phosphate 4-kinase type 2 beta "GO:0005515,GO:0005524,GO:0005525,GO:0005634,GO:0005654,GO:0005776,GO:0005789,GO:0005829,GO:0005886,GO:0006644,GO:0006661,GO:0007166,GO:0010506,GO:0014066,GO:0016308,GO:0016309,GO:0042803,GO:0046627,GO:0046854,GO:0061909,GO:0090217,GO:1902635,GO:2000786" "protein binding|ATP binding|GTP binding|nucleus|nucleoplasm|autophagosome|endoplasmic reticulum membrane|cytosol|plasma membrane|phospholipid metabolic process|phosphatidylinositol biosynthetic process|cell surface receptor signaling pathway|regulation of autophagy|regulation of phosphatidylinositol 3-kinase signaling|1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|protein homodimerization activity|negative regulation of insulin receptor signaling pathway|phosphatidylinositol phosphorylation|autophagosome-lysosome fusion|negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process|positive regulation of autophagosome assembly" "hsa00562,hsa04070,hsa04810" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Regulation of actin cytoskeleton PIP4K2C 1384.883153 1447.215711 1322.550595 0.91385865 -0.12995706 0.589072488 1 23.04841618 20.7105338 79837 phosphatidylinositol-5-phosphate 4-kinase type 2 gamma "GO:0005515,GO:0005524,GO:0005654,GO:0005776,GO:0005783,GO:0005829,GO:0005886,GO:0006661,GO:0010506,GO:0014066,GO:0016308,GO:0016309,GO:0042802,GO:0043229,GO:0046627,GO:0046854,GO:0070062,GO:0090217,GO:1902635,GO:2000786" "protein binding|ATP binding|nucleoplasm|autophagosome|endoplasmic reticulum|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|regulation of autophagy|regulation of phosphatidylinositol 3-kinase signaling|1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|identical protein binding|intracellular organelle|negative regulation of insulin receptor signaling pathway|phosphatidylinositol phosphorylation|extracellular exosome|negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process|positive regulation of autophagosome assembly" "hsa00562,hsa04070,hsa04810" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Regulation of actin cytoskeleton PIP4P1 650.2673934 682.511507 618.0232797 0.905513348 -0.143192187 0.583662202 1 18.03187363 16.05487358 90809 "phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1" "GO:0005515,GO:0005654,GO:0005765,GO:0005886,GO:0006644,GO:0006991,GO:0008203,GO:0016021,GO:0030670,GO:0031902,GO:0032418,GO:0034597,GO:0046856,GO:0070070,GO:1904263" "protein binding|nucleoplasm|lysosomal membrane|plasma membrane|phospholipid metabolic process|response to sterol depletion|cholesterol metabolic process|integral component of membrane|phagocytic vesicle membrane|late endosome membrane|lysosome localization|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity|phosphatidylinositol dephosphorylation|proton-transporting V-type ATPase complex assembly|positive regulation of TORC1 signaling" hsa04070 Phosphatidylinositol signaling system PIP4P2 733.1645794 688.7539903 777.5751684 1.128959221 0.174993376 0.493752041 1 12.12719716 13.46200886 55529 "phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2" "GO:0005515,GO:0005765,GO:0005886,GO:0016021,GO:0030670,GO:0031902,GO:0034597,GO:0046856,GO:0050765" "protein binding|lysosomal membrane|plasma membrane|integral component of membrane|phagocytic vesicle membrane|late endosome membrane|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity|phosphatidylinositol dephosphorylation|negative regulation of phagocytosis" hsa04070 Phosphatidylinositol signaling system PIP5K1A 3686.495353 3822.480605 3550.510101 0.928849736 -0.10648287 0.654620359 1 43.34865373 39.59061562 8394 phosphatidylinositol-4-phosphate 5-kinase type 1 alpha "GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005847,GO:0005886,GO:0005925,GO:0006650,GO:0006661,GO:0006909,GO:0007165,GO:0008654,GO:0010761,GO:0014066,GO:0016308,GO:0016477,GO:0016607,GO:0019900,GO:0030027,GO:0030216,GO:0031532,GO:0032587,GO:0046854,GO:0048041,GO:0060326,GO:0072659,GO:0090630,GO:0097178" protein binding|ATP binding|nucleus|nucleoplasm|cytosol|mRNA cleavage and polyadenylation specificity factor complex|plasma membrane|focal adhesion|glycerophospholipid metabolic process|phosphatidylinositol biosynthetic process|phagocytosis|signal transduction|phospholipid biosynthetic process|fibroblast migration|regulation of phosphatidylinositol 3-kinase signaling|1-phosphatidylinositol-4-phosphate 5-kinase activity|cell migration|nuclear speck|kinase binding|lamellipodium|keratinocyte differentiation|actin cytoskeleton reorganization|ruffle membrane|phosphatidylinositol phosphorylation|focal adhesion assembly|cell chemotaxis|protein localization to plasma membrane|activation of GTPase activity|ruffle assembly "hsa00562,hsa04070,hsa04072,hsa04144,hsa04510,hsa04666,hsa04810,hsa05135,hsa05231" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Endocytosis|Focal adhesion|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Yersinia infection|Choline metabolism in cancer PIP5K1C 882.1073108 977.9890497 786.225572 0.803920629 -0.314875024 0.205781701 1 6.602590527 5.219137229 23396 phosphatidylinositol-4-phosphate 5-kinase type 1 gamma "GO:0001891,GO:0001931,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0005912,GO:0005925,GO:0006661,GO:0006909,GO:0010008,GO:0014066,GO:0016079,GO:0016308,GO:0030036,GO:0030593,GO:0032587,GO:0034333,GO:0046854,GO:0048488,GO:0061024,GO:0072583,GO:0098609,GO:0098793" phagocytic cup|uropod|protein binding|ATP binding|nucleoplasm|cytosol|adherens junction|focal adhesion|phosphatidylinositol biosynthetic process|phagocytosis|endosome membrane|regulation of phosphatidylinositol 3-kinase signaling|synaptic vesicle exocytosis|1-phosphatidylinositol-4-phosphate 5-kinase activity|actin cytoskeleton organization|neutrophil chemotaxis|ruffle membrane|adherens junction assembly|phosphatidylinositol phosphorylation|synaptic vesicle endocytosis|membrane organization|clathrin-dependent endocytosis|cell-cell adhesion|presynapse "hsa00562,hsa04070,hsa04072,hsa04144,hsa04510,hsa04666,hsa04810,hsa05135,hsa05231" Inositol phosphate metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Endocytosis|Focal adhesion|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Yersinia infection|Choline metabolism in cancer PIP5KL1 157.2867786 155.0216685 159.5518887 1.029223142 0.041555801 0.933961454 1 2.464468731 2.494043554 138429 phosphatidylinositol-4-phosphate 5-kinase like 1 "GO:0001933,GO:0005524,GO:0005829,GO:0010917,GO:0016020,GO:0016308,GO:0030336,GO:0042995,GO:0043065,GO:0046854" negative regulation of protein phosphorylation|ATP binding|cytosol|negative regulation of mitochondrial membrane potential|membrane|1-phosphatidylinositol-4-phosphate 5-kinase activity|negative regulation of cell migration|cell projection|positive regulation of apoptotic process|phosphatidylinositol phosphorylation "hsa00562,hsa04144" Inositol phosphate metabolism|Endocytosis PIPOX 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.070344143 0.021299313 51268 pipecolic acid and sarcosine oxidase "GO:0005515,GO:0005777,GO:0005782,GO:0005829,GO:0006554,GO:0006625,GO:0008115,GO:0033514,GO:0046653,GO:0050031,GO:0055114" protein binding|peroxisome|peroxisomal matrix|cytosol|lysine catabolic process|protein targeting to peroxisome|sarcosine oxidase activity|L-lysine catabolic process to acetyl-CoA via L-pipecolate|tetrahydrofolate metabolic process|L-pipecolate oxidase activity|oxidation-reduction process "hsa00260,hsa00310,hsa04146" "Glycine, serine and threonine metabolism|Lysine degradation|Peroxisome" PIR 275.4039368 316.2858203 234.5220533 0.741487725 -0.431505286 0.183565846 1 12.90488756 9.408694538 8544 pirin "GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006366,GO:0007586,GO:0008127,GO:0030224,GO:0046872,GO:0055114" "transcription coregulator activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|transcription by RNA polymerase II|digestion|quercetin 2,3-dioxygenase activity|monocyte differentiation|metal ion binding|oxidation-reduction process" PISD 1226.867348 1411.841639 1041.893056 0.737967367 -0.438371074 0.069715862 1 22.93680165 16.6433672 23761 phosphatidylserine decarboxylase "GO:0004609,GO:0005634,GO:0005739,GO:0006646,GO:0016540,GO:0031305" phosphatidylserine decarboxylase activity|nucleus|mitochondrion|phosphatidylethanolamine biosynthetic process|protein autoprocessing|integral component of mitochondrial inner membrane hsa00564 Glycerophospholipid metabolism PITHD1 563.1399691 539.9748051 586.3051332 1.085800907 0.118759594 0.659915851 1 18.11279882 19.33779456 57095 PITH domain containing 1 "GO:0005634,GO:0005737,GO:0007286,GO:0007341,GO:0045654,GO:0045893,GO:0061136,GO:0061956,GO:0097598" "nucleus|cytoplasm|spermatid development|penetration of zona pellucida|positive regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-templated|regulation of proteasomal protein catabolic process|penetration of cumulus oophorus|sperm cytoplasmic droplet" PITPNA 1553.501242 1508.60013 1598.402355 1.059526858 0.083420158 0.728169533 1 20.64919627 21.512273 5306 phosphatidylinositol transfer protein alpha "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006629,GO:0007601,GO:0008525,GO:0008526,GO:0015914,GO:0031210,GO:0035091,GO:0035722,GO:0070062,GO:0120009,GO:0120019,GO:1901611" protein binding|nucleus|cytoplasm|cytosol|lipid metabolic process|visual perception|phosphatidylcholine transporter activity|phosphatidylinositol transfer activity|phospholipid transport|phosphatidylcholine binding|phosphatidylinositol binding|interleukin-12-mediated signaling pathway|extracellular exosome|intermembrane lipid transfer|phosphatidylcholine transfer activity|phosphatidylglycerol binding PITPNB 2279.556532 2149.495082 2409.617982 1.121015815 0.164806632 0.486188166 1 36.00583864 39.6876925 23760 phosphatidylinositol transfer protein beta "GO:0000139,GO:0005515,GO:0005737,GO:0005789,GO:0005794,GO:0006629,GO:0006890,GO:0006997,GO:0008525,GO:0008526,GO:0015914,GO:0031210,GO:0035091,GO:0120009,GO:0120019,GO:0140338" "Golgi membrane|protein binding|cytoplasm|endoplasmic reticulum membrane|Golgi apparatus|lipid metabolic process|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|nucleus organization|phosphatidylcholine transporter activity|phosphatidylinositol transfer activity|phospholipid transport|phosphatidylcholine binding|phosphatidylinositol binding|intermembrane lipid transfer|phosphatidylcholine transfer activity|sphingomyelin transfer activity" PITPNC1 456.2692188 396.3976893 516.1407484 1.302078096 0.380815981 0.173129523 1 3.272743832 4.190059833 26207 phosphatidylinositol transfer protein cytoplasmic 1 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0008525,GO:0008526,GO:0015914,GO:0035091,GO:0070300,GO:0120009,GO:1901611,GO:1990050" protein binding|nucleoplasm|cytoplasm|cytosol|signal transduction|phosphatidylcholine transporter activity|phosphatidylinositol transfer activity|phospholipid transport|phosphatidylinositol binding|phosphatidic acid binding|intermembrane lipid transfer|phosphatidylglycerol binding|phosphatidic acid transfer activity PITPNM1 1792.734112 1644.894348 1940.573875 1.179755938 0.238488433 0.314760621 1 19.63869982 22.78117302 9600 phosphatidylinositol transfer protein membrane associated 1 "GO:0005509,GO:0005515,GO:0005737,GO:0005789,GO:0005811,GO:0005829,GO:0006629,GO:0006661,GO:0007420,GO:0007602,GO:0008525,GO:0008526,GO:0015031,GO:0015914,GO:0016020,GO:0030496,GO:0030971,GO:0031210,GO:0032154,GO:0032580,GO:0035091,GO:0043231,GO:0044297,GO:0070300,GO:0120009" calcium ion binding|protein binding|cytoplasm|endoplasmic reticulum membrane|lipid droplet|cytosol|lipid metabolic process|phosphatidylinositol biosynthetic process|brain development|phototransduction|phosphatidylcholine transporter activity|phosphatidylinositol transfer activity|protein transport|phospholipid transport|membrane|midbody|receptor tyrosine kinase binding|phosphatidylcholine binding|cleavage furrow|Golgi cisterna membrane|phosphatidylinositol binding|intracellular membrane-bounded organelle|cell body|phosphatidic acid binding|intermembrane lipid transfer PITPNM2 368.4769343 413.0443114 323.9095572 0.784200504 -0.350705526 0.236332084 1 2.696772175 2.079421616 57605 phosphatidylinositol transfer protein membrane associated 2 "GO:0005509,GO:0005737,GO:0005829,GO:0006661,GO:0008525,GO:0008526,GO:0012505,GO:0015914,GO:0016020,GO:0030971,GO:0031210,GO:0035091,GO:0044297,GO:0048015,GO:0120009" calcium ion binding|cytoplasm|cytosol|phosphatidylinositol biosynthetic process|phosphatidylcholine transporter activity|phosphatidylinositol transfer activity|endomembrane system|phospholipid transport|membrane|receptor tyrosine kinase binding|phosphatidylcholine binding|phosphatidylinositol binding|cell body|phosphatidylinositol-mediated signaling|intermembrane lipid transfer PITPNM3 113.6089028 118.6071826 108.610623 0.915717081 -0.127026162 0.79312522 1 0.660942607 0.595108622 83394 PITPNM family member 3 "GO:0004620,GO:0005509,GO:0005515,GO:0005737,GO:0005829,GO:0006661,GO:0008289,GO:0012505,GO:0016020,GO:0030134,GO:0030971,GO:0042995,GO:0044297" phospholipase activity|calcium ion binding|protein binding|cytoplasm|cytosol|phosphatidylinositol biosynthetic process|lipid binding|endomembrane system|membrane|COPII-coated ER to Golgi transport vesicle|receptor tyrosine kinase binding|cell projection|cell body PITRM1 1599.452446 1667.783454 1531.121438 0.918057698 -0.123343269 0.605523353 1 22.44239477 20.25864306 10531 pitrilysin metallopeptidase 1 "GO:0004222,GO:0005739,GO:0005759,GO:0006508,GO:0006626,GO:0008047,GO:0008237,GO:0008270,GO:0016485,GO:0050790" metalloendopeptidase activity|mitochondrion|mitochondrial matrix|proteolysis|protein targeting to mitochondrion|enzyme activator activity|metallopeptidase activity|zinc ion binding|protein processing|regulation of catalytic activity PITX1 473.985823 457.7821084 490.1895376 1.070792258 0.098678613 0.727226087 1 10.45399647 11.00674108 5307 paired like homeodomain 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001085,GO:0001228,GO:0001501,GO:0003700,GO:0005515,GO:0005634,GO:0005667,GO:0005737,GO:0006357,GO:0009653,GO:0014707,GO:0021983,GO:0035116,GO:0045892,GO:0045944,GO:0048625,GO:0051216,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|skeletal system development|DNA-binding transcription factor activity|protein binding|nucleus|transcription regulator complex|cytoplasm|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|branchiomeric skeletal muscle development|pituitary gland development|embryonic hindlimb morphogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|myoblast fate commitment|cartilage development|sequence-specific double-stranded DNA binding" Homeobox PITX3 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.116812714 0.070738811 5309 paired like homeodomain 3 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0002088,GO:0002089,GO:0005634,GO:0006355,GO:0006357,GO:0007568,GO:0007626,GO:0009653,GO:0009887,GO:0014014,GO:0030901,GO:0035902,GO:0042220,GO:0043025,GO:0043278,GO:0043525,GO:0045893,GO:0045944,GO:0048666,GO:0070306,GO:0071542,GO:1904313,GO:1904935,GO:1990792,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|lens development in camera-type eye|lens morphogenesis in camera-type eye|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|aging|locomotory behavior|anatomical structure morphogenesis|animal organ morphogenesis|negative regulation of gliogenesis|midbrain development|response to immobilization stress|response to cocaine|neuronal cell body|response to morphine|positive regulation of neuron apoptotic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|neuron development|lens fiber cell differentiation|dopaminergic neuron differentiation|response to methamphetamine hydrochloride|positive regulation of cell proliferation in midbrain|cellular response to glial cell derived neurotrophic factor|sequence-specific double-stranded DNA binding" PIWIL2 6.604174384 9.363724944 3.844623824 0.41058701 -1.284240111 0.3924594 1 0.086999441 0.035123101 55124 piwi like RNA-mediated gene silencing 2 "GO:0000966,GO:0003729,GO:0004521,GO:0005515,GO:0005634,GO:0005737,GO:0007275,GO:0007283,GO:0010370,GO:0010529,GO:0030718,GO:0031047,GO:0033391,GO:0034584,GO:0034587,GO:0042754,GO:0043046,GO:0043186,GO:0045727,GO:0046872,GO:0048477,GO:0048511,GO:0051321,GO:0060903,GO:0071442,GO:0071546,GO:0090502,GO:0097433,GO:1905538,GO:1990511,GO:1990923,GO:2000617" "RNA 5'-end processing|mRNA binding|endoribonuclease activity|protein binding|nucleus|cytoplasm|multicellular organism development|spermatogenesis|perinucleolar chromocenter|negative regulation of transposition|germ-line stem cell population maintenance|gene silencing by RNA|chromatoid body|piRNA binding|piRNA metabolic process|negative regulation of circadian rhythm|DNA methylation involved in gamete generation|P granule|positive regulation of translation|metal ion binding|oogenesis|rhythmic process|meiotic cell cycle|positive regulation of meiosis I|positive regulation of histone H3-K14 acetylation|pi-body|RNA phosphodiester bond hydrolysis, endonucleolytic|dense body|polysome binding|piRNA biosynthetic process|PET complex|positive regulation of histone H3-K9 acetylation" PIWIL4 4.964295633 4.161655531 5.766935736 1.385731158 0.470647391 0.897151737 1 0.070754988 0.096406701 143689 piwi like RNA-mediated gene silencing 4 "GO:0004521,GO:0005634,GO:0005737,GO:0006417,GO:0007275,GO:0007283,GO:0010529,GO:0010669,GO:0030154,GO:0031047,GO:0034584,GO:0034587,GO:0043046,GO:0043186,GO:0051321,GO:0071547,GO:0090502" "endoribonuclease activity|nucleus|cytoplasm|regulation of translation|multicellular organism development|spermatogenesis|negative regulation of transposition|epithelial structure maintenance|cell differentiation|gene silencing by RNA|piRNA binding|piRNA metabolic process|DNA methylation involved in gamete generation|P granule|meiotic cell cycle|piP-body|RNA phosphodiester bond hydrolysis, endonucleolytic" PJA1 703.7901864 636.7332962 770.8470767 1.210627874 0.275755474 0.282027625 1 12.12318436 14.43107079 64219 praja ring finger ubiquitin ligase 1 "GO:0005515,GO:0005737,GO:0016567,GO:0030163,GO:0046872,GO:0061630" protein binding|cytoplasm|protein ubiquitination|protein catabolic process|metal ion binding|ubiquitin protein ligase activity PJA2 4505.417892 4176.221325 4834.614459 1.157652836 0.211202673 0.377092231 1 44.66478087 50.84107515 9867 praja ring finger ubiquitin ligase 2 "GO:0000139,GO:0004842,GO:0005515,GO:0005737,GO:0005789,GO:0005886,GO:0006954,GO:0007616,GO:0010738,GO:0014069,GO:0016567,GO:0034137,GO:0034236,GO:0034237,GO:0035329,GO:0043030,GO:0045087,GO:0045111,GO:0046330,GO:0046872,GO:1900745" Golgi membrane|ubiquitin-protein transferase activity|protein binding|cytoplasm|endoplasmic reticulum membrane|plasma membrane|inflammatory response|long-term memory|regulation of protein kinase A signaling|postsynaptic density|protein ubiquitination|positive regulation of toll-like receptor 2 signaling pathway|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|hippo signaling|regulation of macrophage activation|innate immune response|intermediate filament cytoskeleton|positive regulation of JNK cascade|metal ion binding|positive regulation of p38MAPK cascade PJVK 15.4527228 14.56579436 16.33965125 1.121782366 0.165792809 0.933361885 1 0.238670456 0.263256104 494513 pejvakin "GO:0000302,GO:0000425,GO:0005737,GO:0005778,GO:0007605,GO:0030864,GO:0035253,GO:0043025,GO:0050910,GO:0097468,GO:0120044,GO:0120045,GO:1900063" response to reactive oxygen species|pexophagy|cytoplasm|peroxisomal membrane|sensory perception of sound|cortical actin cytoskeleton|ciliary rootlet|neuronal cell body|detection of mechanical stimulus involved in sensory perception of sound|programmed cell death in response to reactive oxygen species|stereocilium base|stereocilium maintenance|regulation of peroxisome organization PKD1 1241.101633 1369.18467 1113.018597 0.81290612 -0.298839346 0.215928154 1 4.917616889 3.930667097 5310 "polycystin 1, transient receptor potential channel interacting" "GO:0000139,GO:0001502,GO:0001701,GO:0001822,GO:0001889,GO:0001892,GO:0002133,GO:0005262,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0005929,GO:0006611,GO:0007050,GO:0007156,GO:0007160,GO:0007161,GO:0007204,GO:0007259,GO:0007507,GO:0009653,GO:0009986,GO:0016021,GO:0016055,GO:0016323,GO:0016328,GO:0018105,GO:0019901,GO:0019904,GO:0021510,GO:0021915,GO:0030010,GO:0030155,GO:0030246,GO:0030660,GO:0031514,GO:0032092,GO:0034405,GO:0034703,GO:0034704,GO:0036303,GO:0042813,GO:0042994,GO:0043588,GO:0044325,GO:0045737,GO:0045944,GO:0048565,GO:0048754,GO:0048806,GO:0050982,GO:0051216,GO:0051290,GO:0060170,GO:0060236,GO:0060428,GO:0060674,GO:0061136,GO:0070062,GO:0070588,GO:0072164,GO:0072177,GO:0072205,GO:0072218,GO:0072237,GO:0072287,GO:0198738,GO:2000045" Golgi membrane|cartilage condensation|in utero embryonic development|kidney development|liver development|embryonic placenta development|polycystin complex|calcium channel activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|cilium|protein export from nucleus|cell cycle arrest|homophilic cell adhesion via plasma membrane adhesion molecules|cell-matrix adhesion|calcium-independent cell-matrix adhesion|positive regulation of cytosolic calcium ion concentration|receptor signaling pathway via JAK-STAT|heart development|anatomical structure morphogenesis|cell surface|integral component of membrane|Wnt signaling pathway|basolateral plasma membrane|lateral plasma membrane|peptidyl-serine phosphorylation|protein kinase binding|protein domain specific binding|spinal cord development|neural tube development|establishment of cell polarity|regulation of cell adhesion|carbohydrate binding|Golgi-associated vesicle membrane|motile cilium|positive regulation of protein binding|response to fluid shear stress|cation channel complex|calcium channel complex|lymph vessel morphogenesis|Wnt-activated receptor activity|cytoplasmic sequestering of transcription factor|skin development|ion channel binding|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription by RNA polymerase II|digestive tract development|branching morphogenesis of an epithelial tube|genitalia development|detection of mechanical stimulus|cartilage development|protein heterotetramerization|ciliary membrane|regulation of mitotic spindle organization|lung epithelium development|placenta blood vessel development|regulation of proteasomal protein catabolic process|extracellular exosome|calcium ion transmembrane transport|mesonephric tubule development|mesonephric duct development|metanephric collecting duct development|metanephric ascending thin limb development|metanephric proximal tubule development|metanephric distal tubule morphogenesis|cell-cell signaling by wnt|regulation of G1/S transition of mitotic cell cycle PKD1L1 123.1808334 117.5667687 128.7948981 1.095504278 0.131595118 0.777856389 1 0.396531781 0.427133129 168507 "polycystin 1 like 1, transient receptor potential channel interacting" "GO:0003127,GO:0005262,GO:0005515,GO:0005929,GO:0016020,GO:0034704,GO:0050982,GO:0060170,GO:0070588,GO:0070986,GO:0097730,GO:0098609" detection of nodal flow|calcium channel activity|protein binding|cilium|membrane|calcium channel complex|detection of mechanical stimulus|ciliary membrane|calcium ion transmembrane transport|left/right axis specification|non-motile cilium|cell-cell adhesion PKD1L2 25.81723267 34.33365813 17.30080721 0.503902239 -0.988784228 0.201510925 1 0.222747901 0.110364929 114780 polycystin 1 like 2 (gene/pseudogene) "GO:0005262,GO:0005509,GO:0016020,GO:0016021,GO:0030246,GO:0050982,GO:0070588" calcium channel activity|calcium ion binding|membrane|integral component of membrane|carbohydrate binding|detection of mechanical stimulus|calcium ion transmembrane transport PKD2 1065.256596 1054.979677 1075.533515 1.019482686 0.027837274 0.913292091 1 10.67545059 10.70131746 5311 "polycystin 2, transient receptor potential cation channel" "GO:0001658,GO:0001889,GO:0001892,GO:0001947,GO:0002133,GO:0003127,GO:0005102,GO:0005244,GO:0005245,GO:0005248,GO:0005249,GO:0005261,GO:0005262,GO:0005267,GO:0005509,GO:0005515,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005887,GO:0005911,GO:0005929,GO:0006816,GO:0007050,GO:0007259,GO:0007368,GO:0007507,GO:0008092,GO:0008285,GO:0009925,GO:0015271,GO:0016020,GO:0016055,GO:0021510,GO:0021915,GO:0022843,GO:0030027,GO:0030659,GO:0031514,GO:0031587,GO:0031941,GO:0034614,GO:0034703,GO:0035502,GO:0035725,GO:0035904,GO:0036064,GO:0042127,GO:0042802,GO:0042803,GO:0042805,GO:0042994,GO:0043398,GO:0044325,GO:0044782,GO:0045180,GO:0045429,GO:0045737,GO:0045944,GO:0048763,GO:0050982,GO:0051117,GO:0051209,GO:0051219,GO:0051262,GO:0051289,GO:0051290,GO:0051298,GO:0051371,GO:0060170,GO:0060315,GO:0060674,GO:0061333,GO:0061441,GO:0070062,GO:0070588,GO:0071158,GO:0071277,GO:0071320,GO:0071458,GO:0071464,GO:0071470,GO:0071498,GO:0071556,GO:0071805,GO:0071910,GO:0072075,GO:0072164,GO:0072177,GO:0072208,GO:0072214,GO:0072218,GO:0072219,GO:0072235,GO:0072284,GO:0072686,GO:0090279,GO:0097730,GO:0098662,GO:0198738,GO:2000134" "branching involved in ureteric bud morphogenesis|liver development|embryonic placenta development|heart looping|polycystin complex|detection of nodal flow|signaling receptor binding|voltage-gated ion channel activity|voltage-gated calcium channel activity|voltage-gated sodium channel activity|voltage-gated potassium channel activity|cation channel activity|calcium channel activity|potassium channel activity|calcium ion binding|protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|cell-cell junction|cilium|calcium ion transport|cell cycle arrest|receptor signaling pathway via JAK-STAT|determination of left/right symmetry|heart development|cytoskeletal protein binding|negative regulation of cell population proliferation|basal plasma membrane|outward rectifier potassium channel activity|membrane|Wnt signaling pathway|spinal cord development|neural tube development|voltage-gated cation channel activity|lamellipodium|cytoplasmic vesicle membrane|motile cilium|positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|filamentous actin|cellular response to reactive oxygen species|cation channel complex|metanephric part of ureteric bud development|sodium ion transmembrane transport|aorta development|ciliary basal body|regulation of cell population proliferation|identical protein binding|protein homodimerization activity|actinin binding|cytoplasmic sequestering of transcription factor|HLH domain binding|ion channel binding|cilium organization|basal cortex|positive regulation of nitric oxide biosynthetic process|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription by RNA polymerase II|calcium-induced calcium release activity|detection of mechanical stimulus|ATPase binding|release of sequestered calcium ion into cytosol|phosphoprotein binding|protein tetramerization|protein homotetramerization|protein heterotetramerization|centrosome duplication|muscle alpha-actinin binding|ciliary membrane|negative regulation of ryanodine-sensitive calcium-release channel activity|placenta blood vessel development|renal tubule morphogenesis|renal artery morphogenesis|extracellular exosome|calcium ion transmembrane transport|positive regulation of cell cycle arrest|cellular response to calcium ion|cellular response to cAMP|integral component of cytoplasmic side of endoplasmic reticulum membrane|cellular response to hydrostatic pressure|cellular response to osmotic stress|cellular response to fluid shear stress|integral component of lumenal side of endoplasmic reticulum membrane|potassium ion transmembrane transport|determination of liver left/right asymmetry|metanephric mesenchyme development|mesonephric tubule development|mesonephric duct development|metanephric smooth muscle tissue development|metanephric cortex development|metanephric ascending thin limb development|metanephric cortical collecting duct development|metanephric distal tubule development|metanephric S-shaped body morphogenesis|mitotic spindle|regulation of calcium ion import|non-motile cilium|inorganic cation transmembrane transport|cell-cell signaling by wnt|negative regulation of G1/S transition of mitotic cell cycle" PKDCC 5.003924597 5.202069413 4.80577978 0.923820772 -0.11431511 1 1 0.111495937 0.101278659 91461 "protein kinase domain containing, cytoplasmic" "GO:0001501,GO:0004672,GO:0004715,GO:0005524,GO:0005576,GO:0005794,GO:0015031,GO:0018108,GO:0030154,GO:0030282,GO:0030501,GO:0032332,GO:0035108,GO:0035264,GO:0042997,GO:0048286,GO:0048566,GO:0060021" skeletal system development|protein kinase activity|non-membrane spanning protein tyrosine kinase activity|ATP binding|extracellular region|Golgi apparatus|protein transport|peptidyl-tyrosine phosphorylation|cell differentiation|bone mineralization|positive regulation of bone mineralization|positive regulation of chondrocyte differentiation|limb morphogenesis|multicellular organism growth|negative regulation of Golgi to plasma membrane protein transport|lung alveolus development|embryonic digestive tract development|roof of mouth development PKHD1 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.001734451 0.004726527 5314 PKHD1 ciliary IPT domain containing fibrocystin/polyductin "GO:0000132,GO:0000775,GO:0001822,GO:0001952,GO:0003382,GO:0005515,GO:0005737,GO:0005783,GO:0005794,GO:0005813,GO:0005929,GO:0006874,GO:0008284,GO:0010824,GO:0016021,GO:0016324,GO:0022407,GO:0030155,GO:0031362,GO:0032006,GO:0032088,GO:0036064,GO:0038023,GO:0042592,GO:0043066,GO:0045216,GO:0048471,GO:0048754,GO:0050679,GO:0051271,GO:0051660,GO:0051898,GO:0060271,GO:0070062,GO:0070372,GO:0072686,GO:0090175,GO:0097731,GO:0098609,GO:1904036,GO:1904054" "establishment of mitotic spindle orientation|chromosome, centromeric region|kidney development|regulation of cell-matrix adhesion|epithelial cell morphogenesis|protein binding|cytoplasm|endoplasmic reticulum|Golgi apparatus|centrosome|cilium|cellular calcium ion homeostasis|positive regulation of cell population proliferation|regulation of centrosome duplication|integral component of membrane|apical plasma membrane|regulation of cell-cell adhesion|regulation of cell adhesion|anchored component of external side of plasma membrane|regulation of TOR signaling|negative regulation of NF-kappaB transcription factor activity|ciliary basal body|signaling receptor activity|homeostatic process|negative regulation of apoptotic process|cell-cell junction organization|perinuclear region of cytoplasm|branching morphogenesis of an epithelial tube|positive regulation of epithelial cell proliferation|negative regulation of cellular component movement|establishment of centrosome localization|negative regulation of protein kinase B signaling|cilium assembly|extracellular exosome|regulation of ERK1 and ERK2 cascade|mitotic spindle|regulation of establishment of planar polarity|9+0 non-motile cilium|cell-cell adhesion|negative regulation of epithelial cell apoptotic process|regulation of cholangiocyte proliferation" PKIA 2016.835092 1964.30141 2069.368773 1.053488412 0.075174445 0.752221415 1 24.16578055 25.03235844 5569 cAMP-dependent protein kinase inhibitor alpha "GO:0000122,GO:0004862,GO:0005515,GO:0005634,GO:0005737,GO:0010389,GO:0034236,GO:0042308,GO:2000480" negative regulation of transcription by RNA polymerase II|cAMP-dependent protein kinase inhibitor activity|protein binding|nucleus|cytoplasm|regulation of G2/M transition of mitotic cell cycle|protein kinase A catalytic subunit binding|negative regulation of protein import into nucleus|negative regulation of cAMP-dependent protein kinase activity hsa05034 Alcoholism PKIB 74.73680682 82.19269673 67.28091692 0.818575367 -0.288812841 0.590845509 1 1.883414839 1.515918448 5570 cAMP-dependent protein kinase inhibitor beta "GO:0004862,GO:0005634,GO:0005737,GO:0032212,GO:0051973,GO:1904355,GO:2000480" cAMP-dependent protein kinase inhibitor activity|nucleus|cytoplasm|positive regulation of telomere maintenance via telomerase|positive regulation of telomerase activity|positive regulation of telomere capping|negative regulation of cAMP-dependent protein kinase activity PKIG 532.5119263 518.1261136 546.897739 1.055530159 0.0779678 0.778124773 1 13.44260496 13.95164 11142 cAMP-dependent protein kinase inhibitor gamma "GO:0000122,GO:0004862,GO:0005515,GO:0005634,GO:0005737,GO:0007165,GO:0042308,GO:2000480" negative regulation of transcription by RNA polymerase II|cAMP-dependent protein kinase inhibitor activity|protein binding|nucleus|cytoplasm|signal transduction|negative regulation of protein import into nucleus|negative regulation of cAMP-dependent protein kinase activity PKM 37360.63275 34937.09818 39784.16733 1.138737028 0.187434619 0.54068949 1 555.5806669 622.0735642 5315 pyruvate kinase M1/2 "GO:0000287,GO:0001666,GO:0001889,GO:0003723,GO:0003729,GO:0004743,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005739,GO:0005791,GO:0005829,GO:0005929,GO:0006096,GO:0006754,GO:0007584,GO:0009629,GO:0012501,GO:0014870,GO:0016301,GO:0023026,GO:0030955,GO:0031100,GO:0031982,GO:0032869,GO:0034774,GO:0042802,GO:0042866,GO:0043312,GO:0043403,GO:0043531,GO:0045296,GO:0061621,GO:0062023,GO:0070062,GO:0070324,GO:1902912,GO:1903561,GO:1903672,GO:1904813,GO:2000767" magnesium ion binding|response to hypoxia|liver development|RNA binding|mRNA binding|pyruvate kinase activity|protein binding|ATP binding|extracellular region|nucleus|cytoplasm|mitochondrion|rough endoplasmic reticulum|cytosol|cilium|glycolytic process|ATP biosynthetic process|response to nutrient|response to gravity|programmed cell death|response to muscle inactivity|kinase activity|MHC class II protein complex binding|potassium ion binding|animal organ regeneration|vesicle|cellular response to insulin stimulus|secretory granule lumen|identical protein binding|pyruvate biosynthetic process|neutrophil degranulation|skeletal muscle tissue regeneration|ADP binding|cadherin binding|canonical glycolysis|collagen-containing extracellular matrix|extracellular exosome|thyroid hormone binding|pyruvate kinase complex|extracellular vesicle|positive regulation of sprouting angiogenesis|ficolin-1-rich granule lumen|positive regulation of cytoplasmic translation "hsa00010,hsa00230,hsa00620,hsa04922,hsa04930,hsa05165,hsa05203,hsa05230" Glycolysis / Gluconeogenesis|Purine metabolism|Pyruvate metabolism|Glucagon signaling pathway|Type II diabetes mellitus|Human papillomavirus infection|Viral carcinogenesis|Central carbon metabolism in cancer PKMYT1 669.4263458 642.9757795 695.8769121 1.082275467 0.114067749 0.662121778 1 13.65476944 14.53092845 9088 "protein kinase, membrane associated tyrosine/threonine 1" "GO:0000079,GO:0000086,GO:0000139,GO:0000278,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006468,GO:0007088,GO:0010923,GO:0016020,GO:0016301,GO:0046872,GO:0051321,GO:0106310,GO:0106311" regulation of cyclin-dependent protein serine/threonine kinase activity|G2/M transition of mitotic cell cycle|Golgi membrane|mitotic cell cycle|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|protein phosphorylation|regulation of mitotic nuclear division|negative regulation of phosphatase activity|membrane|kinase activity|metal ion binding|meiotic cell cycle|protein serine kinase activity|protein threonine kinase activity "hsa04110,hsa04114,hsa04914" Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation PKN1 4851.336615 4716.19613 4986.4771 1.057309103 0.080397208 0.737892938 1 79.3238952 82.46642767 5585 protein kinase N1 "GO:0001782,GO:0001783,GO:0002634,GO:0002637,GO:0003014,GO:0003682,GO:0004672,GO:0004674,GO:0004698,GO:0005080,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005829,GO:0006357,GO:0006468,GO:0006469,GO:0006972,GO:0007165,GO:0007257,GO:0010631,GO:0018105,GO:0030374,GO:0030496,GO:0030889,GO:0031267,GO:0032154,GO:0032991,GO:0035402,GO:0035407,GO:0035556,GO:0042393,GO:0042826,GO:0045893,GO:0048536,GO:0050681,GO:2000145" "B cell homeostasis|B cell apoptotic process|regulation of germinal center formation|regulation of immunoglobulin production|renal system process|chromatin binding|protein kinase activity|protein serine/threonine kinase activity|calcium-dependent protein kinase C activity|protein kinase C binding|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|endosome|cytosol|regulation of transcription by RNA polymerase II|protein phosphorylation|negative regulation of protein kinase activity|hyperosmotic response|signal transduction|activation of JUN kinase activity|epithelial cell migration|peptidyl-serine phosphorylation|nuclear receptor coactivator activity|midbody|negative regulation of B cell proliferation|small GTPase binding|cleavage furrow|protein-containing complex|histone kinase activity (H3-T11 specific)|histone H3-T11 phosphorylation|intracellular signal transduction|histone binding|histone deacetylase binding|positive regulation of transcription, DNA-templated|spleen development|androgen receptor binding|regulation of cell motility" "hsa04151,hsa04621,hsa05132,hsa05135" PI3K-Akt signaling pathway|NOD-like receptor signaling pathway|Salmonella infection|Yersinia infection PKN2 2085.595529 2268.102264 1903.088793 0.839066572 -0.253142815 0.284539475 1 16.07282555 13.26049785 5586 protein kinase N2 "GO:0003723,GO:0004672,GO:0004674,GO:0004698,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0006468,GO:0006915,GO:0007049,GO:0007155,GO:0007165,GO:0010631,GO:0016032,GO:0016301,GO:0016604,GO:0018105,GO:0030027,GO:0030030,GO:0030496,GO:0032154,GO:0032467,GO:0032991,GO:0035556,GO:0042826,GO:0043296,GO:0043297,GO:0045070,GO:0045111,GO:0045296,GO:0045931,GO:0048471,GO:0051301,GO:0070063,GO:2000145" RNA binding|protein kinase activity|protein serine/threonine kinase activity|calcium-dependent protein kinase C activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|plasma membrane|protein phosphorylation|apoptotic process|cell cycle|cell adhesion|signal transduction|epithelial cell migration|viral process|kinase activity|nuclear body|peptidyl-serine phosphorylation|lamellipodium|cell projection organization|midbody|cleavage furrow|positive regulation of cytokinesis|protein-containing complex|intracellular signal transduction|histone deacetylase binding|apical junction complex|apical junction assembly|positive regulation of viral genome replication|intermediate filament cytoskeleton|cadherin binding|positive regulation of mitotic cell cycle|perinuclear region of cytoplasm|cell division|RNA polymerase binding|regulation of cell motility "hsa04151,hsa04621,hsa05135" PI3K-Akt signaling pathway|NOD-like receptor signaling pathway|Yersinia infection PKN3 1457.539132 1525.246752 1389.831512 0.911217487 -0.134132661 0.575892927 1 17.06490899 15.28963791 29941 protein kinase N3 "GO:0004672,GO:0004674,GO:0004698,GO:0005515,GO:0005524,GO:0005634,GO:0005794,GO:0006468,GO:0007165,GO:0010631,GO:0018105,GO:0035556,GO:0048471" protein kinase activity|protein serine/threonine kinase activity|calcium-dependent protein kinase C activity|protein binding|ATP binding|nucleus|Golgi apparatus|protein phosphorylation|signal transduction|epithelial cell migration|peptidyl-serine phosphorylation|intracellular signal transduction|perinuclear region of cytoplasm hsa04151 PI3K-Akt signaling pathway PKNOX1 493.6096477 556.6214272 430.5978683 0.773591973 -0.370355269 0.176636725 1 5.604879725 4.26333472 5316 PBX/knotted 1 homeobox 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001525,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005667,GO:0005737,GO:0006357,GO:0006366,GO:0030217,GO:0030218,GO:0043010,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|angiogenesis|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|transcription regulator complex|cytoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|T cell differentiation|erythrocyte differentiation|camera-type eye development|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" PKP2 750.8465849 736.6130289 765.080141 1.038645952 0.054703961 0.834065398 1 9.014373656 9.206069892 5318 plakophilin 2 "GO:0001533,GO:0002159,GO:0002934,GO:0005080,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005882,GO:0005886,GO:0005911,GO:0005912,GO:0007043,GO:0007507,GO:0010765,GO:0014704,GO:0016021,GO:0017080,GO:0019215,GO:0030054,GO:0030057,GO:0031424,GO:0044325,GO:0045110,GO:0045294,GO:0045296,GO:0048496,GO:0055010,GO:0060090,GO:0070268,GO:0072659,GO:0086002,GO:0086005,GO:0086019,GO:0086064,GO:0086073,GO:0086083,GO:0086091,GO:0098609,GO:0098911,GO:1990124" cornified envelope|desmosome assembly|desmosome organization|protein kinase C binding|protein binding|nucleus|nucleoplasm|cytoplasm|intermediate filament|plasma membrane|cell-cell junction|adherens junction|cell-cell junction assembly|heart development|positive regulation of sodium ion transport|intercalated disc|integral component of membrane|sodium channel regulator activity|intermediate filament binding|cell junction|desmosome|keratinization|ion channel binding|intermediate filament bundle assembly|alpha-catenin binding|cadherin binding|maintenance of animal organ identity|ventricular cardiac muscle tissue morphogenesis|molecular adaptor activity|cornification|protein localization to plasma membrane|cardiac muscle cell action potential involved in contraction|ventricular cardiac muscle cell action potential|cell-cell signaling involved in cardiac conduction|cell communication by electrical coupling involved in cardiac conduction|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|regulation of heart rate by cardiac conduction|cell-cell adhesion|regulation of ventricular cardiac muscle cell action potential|messenger ribonucleoprotein complex hsa05412 Arrhythmogenic right ventricular cardiomyopathy PKP3 429.6342548 403.6805865 455.5879231 1.12858517 0.174515297 0.542355495 1 7.352795552 8.159395938 11187 plakophilin 3 "GO:0001533,GO:0002159,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0005911,GO:0005912,GO:0006417,GO:0007043,GO:0010628,GO:0019899,GO:0030054,GO:0030057,GO:0031424,GO:0045182,GO:0045294,GO:0045296,GO:0050839,GO:0070268,GO:0072659,GO:0098609,GO:0098641,GO:1902373,GO:1990124" cornified envelope|desmosome assembly|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|plasma membrane|cell-cell junction|adherens junction|regulation of translation|cell-cell junction assembly|positive regulation of gene expression|enzyme binding|cell junction|desmosome|keratinization|translation regulator activity|alpha-catenin binding|cadherin binding|cell adhesion molecule binding|cornification|protein localization to plasma membrane|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|negative regulation of mRNA catabolic process|messenger ribonucleoprotein complex PKP4 1405.076875 1523.165924 1286.987825 0.844942632 -0.243074703 0.310305967 1 8.628443468 7.168542426 8502 plakophilin 4 "GO:0000922,GO:0001533,GO:0005515,GO:0005634,GO:0005737,GO:0005856,GO:0005886,GO:0005911,GO:0005912,GO:0007043,GO:0007267,GO:0009898,GO:0030054,GO:0030057,GO:0030155,GO:0030496,GO:0031424,GO:0032467,GO:0043547,GO:0044291,GO:0045296,GO:0048471,GO:0051233,GO:0070268,GO:0072686,GO:0098609" spindle pole|cornified envelope|protein binding|nucleus|cytoplasm|cytoskeleton|plasma membrane|cell-cell junction|adherens junction|cell-cell junction assembly|cell-cell signaling|cytoplasmic side of plasma membrane|cell junction|desmosome|regulation of cell adhesion|midbody|keratinization|positive regulation of cytokinesis|positive regulation of GTPase activity|cell-cell contact zone|cadherin binding|perinuclear region of cytoplasm|spindle midzone|cornification|mitotic spindle|cell-cell adhesion PLA2G12A 588.9276337 548.2981162 629.5571512 1.148202287 0.199376835 0.452065993 1 5.606756607 6.329964724 81579 phospholipase A2 group XIIA "GO:0004623,GO:0005509,GO:0005515,GO:0005576,GO:0005737,GO:0006654,GO:0008150,GO:0016042,GO:0036148,GO:0036149,GO:0036150,GO:0036151,GO:0036152,GO:0047498,GO:0050482,GO:0102567,GO:0102568" "phospholipase A2 activity|calcium ion binding|protein binding|extracellular region|cytoplasm|phosphatidic acid biosynthetic process|biological_process|lipid catabolic process|phosphatidylglycerol acyl-chain remodeling|phosphatidylinositol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|calcium-dependent phospholipase A2 activity|arachidonic acid secretion|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)" "hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04014,hsa04270,hsa04972,hsa04975" Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|Ras signaling pathway|Vascular smooth muscle contraction|Pancreatic secretion|Fat digestion and absorption PLA2G15 510.6582043 486.9136971 534.4027115 1.09753066 0.134261243 0.625850147 1 9.293880223 10.02962998 23659 phospholipase A2 group XV "GO:0004622,GO:0004806,GO:0005543,GO:0005576,GO:0005615,GO:0005654,GO:0005764,GO:0006629,GO:0006644,GO:0006650,GO:0006651,GO:0006658,GO:0006672,GO:0008270,GO:0008374,GO:0008970,GO:0009062,GO:0016020,GO:0016411,GO:0034638,GO:0043231,GO:0046338,GO:0046470,GO:0046471,GO:0047499,GO:0052739,GO:0052740,GO:0070062,GO:0102545,GO:0102567,GO:0102568" "lysophospholipase activity|triglyceride lipase activity|phospholipid binding|extracellular region|extracellular space|nucleoplasm|lysosome|lipid metabolic process|phospholipid metabolic process|glycerophospholipid metabolic process|diacylglycerol biosynthetic process|phosphatidylserine metabolic process|ceramide metabolic process|zinc ion binding|O-acyltransferase activity|phospholipase A1 activity|fatty acid catabolic process|membrane|acylglycerol O-acyltransferase activity|phosphatidylcholine catabolic process|intracellular membrane-bounded organelle|phosphatidylethanolamine catabolic process|phosphatidylcholine metabolic process|phosphatidylglycerol metabolic process|calcium-independent phospholipase A2 activity|phosphatidylserine 1-acylhydrolase activity|1-acyl-2-lysophosphatidylserine acylhydrolase activity|extracellular exosome|phosphatidyl phospholipase B activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)" "hsa00564,hsa04142" Glycerophospholipid metabolism|Lysosome PLA2G4A 517.2466731 634.6524684 399.8408777 0.630015477 -0.666540824 0.014015227 0.707225918 11.15988 6.913244581 5321 phospholipase A2 group IVA "GO:0000139,GO:0001516,GO:0002827,GO:0004622,GO:0004623,GO:0005509,GO:0005544,GO:0005634,GO:0005635,GO:0005737,GO:0005743,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006071,GO:0006640,GO:0006644,GO:0006654,GO:0006663,GO:0006690,GO:0008374,GO:0010314,GO:0010572,GO:0019369,GO:0019370,GO:0032266,GO:0032308,GO:0034478,GO:0034638,GO:0035965,GO:0036148,GO:0036149,GO:0036150,GO:0036151,GO:0036152,GO:0042127,GO:0043032,GO:0043231,GO:0046475,GO:0047498,GO:0047499,GO:0050482,GO:0070273,GO:0071236,GO:0102545,GO:0102567,GO:0102568,GO:1902387" "Golgi membrane|prostaglandin biosynthetic process|positive regulation of T-helper 1 type immune response|lysophospholipase activity|phospholipase A2 activity|calcium ion binding|calcium-dependent phospholipid binding|nucleus|nuclear envelope|cytoplasm|mitochondrial inner membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|glycerol metabolic process|monoacylglycerol biosynthetic process|phospholipid metabolic process|phosphatidic acid biosynthetic process|platelet activating factor biosynthetic process|icosanoid metabolic process|O-acyltransferase activity|phosphatidylinositol-5-phosphate binding|positive regulation of platelet activation|arachidonic acid metabolic process|leukotriene biosynthetic process|phosphatidylinositol-3-phosphate binding|positive regulation of prostaglandin secretion|phosphatidylglycerol catabolic process|phosphatidylcholine catabolic process|cardiolipin acyl-chain remodeling|phosphatidylglycerol acyl-chain remodeling|phosphatidylinositol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|regulation of cell population proliferation|positive regulation of macrophage activation|intracellular membrane-bounded organelle|glycerophospholipid catabolic process|calcium-dependent phospholipase A2 activity|calcium-independent phospholipase A2 activity|arachidonic acid secretion|phosphatidylinositol-4-phosphate binding|cellular response to antibiotic|phosphatidyl phospholipase B activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|ceramide 1-phosphate binding" "hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04010,hsa04014,hsa04072,hsa04217,hsa04270,hsa04370,hsa04611,hsa04664,hsa04666,hsa04724,hsa04726,hsa04730,hsa04750,hsa04912,hsa04913,hsa04921,hsa05231" Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|MAPK signaling pathway|Ras signaling pathway|Phospholipase D signaling pathway|Necroptosis|Vascular smooth muscle contraction|VEGF signaling pathway|Platelet activation|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Glutamatergic synapse|Serotonergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Ovarian steroidogenesis|Oxytocin signaling pathway|Choline metabolism in cancer PLA2G4B 5.643018428 9.363724944 1.922311912 0.205293505 -2.284240111 0.166157707 1 0.18535786 0.037416003 100137049 phospholipase A2 group IVB "GO:0004622,GO:0004623,GO:0005509,GO:0005544,GO:0005576,GO:0005743,GO:0005829,GO:0006644,GO:0006654,GO:0006954,GO:0007567,GO:0019369,GO:0019722,GO:0031901,GO:0036148,GO:0036150,GO:0036151,GO:0036152,GO:0036498,GO:0046475,GO:0047498,GO:0102545,GO:0102567,GO:0102568" "lysophospholipase activity|phospholipase A2 activity|calcium ion binding|calcium-dependent phospholipid binding|extracellular region|mitochondrial inner membrane|cytosol|phospholipid metabolic process|phosphatidic acid biosynthetic process|inflammatory response|parturition|arachidonic acid metabolic process|calcium-mediated signaling|early endosome membrane|phosphatidylglycerol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|IRE1-mediated unfolded protein response|glycerophospholipid catabolic process|calcium-dependent phospholipase A2 activity|phosphatidyl phospholipase B activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)" "hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04010,hsa04014,hsa04072,hsa04217,hsa04270,hsa04370,hsa04611,hsa04664,hsa04666,hsa04724,hsa04726,hsa04730,hsa04750,hsa04912,hsa04913,hsa04921,hsa05231" Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|MAPK signaling pathway|Ras signaling pathway|Phospholipase D signaling pathway|Necroptosis|Vascular smooth muscle contraction|VEGF signaling pathway|Platelet activation|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Glutamatergic synapse|Serotonergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Ovarian steroidogenesis|Oxytocin signaling pathway|Choline metabolism in cancer PLA2G4C 33.7442541 40.57614142 26.91236677 0.663255939 -0.592362407 0.40355072 1 0.538943278 0.351475766 8605 phospholipase A2 group IVC "GO:0004622,GO:0004623,GO:0005509,GO:0005515,GO:0005543,GO:0005544,GO:0005635,GO:0005654,GO:0005789,GO:0005811,GO:0005829,GO:0005886,GO:0006644,GO:0006663,GO:0006954,GO:0007567,GO:0008374,GO:0008970,GO:0016020,GO:0016032,GO:0019369,GO:0031966,GO:0035556,GO:0036149,GO:0036151,GO:0036152,GO:0046475,GO:0047498,GO:0047499,GO:0102545,GO:0102567,GO:0102568,GO:0140042" "lysophospholipase activity|phospholipase A2 activity|calcium ion binding|protein binding|phospholipid binding|calcium-dependent phospholipid binding|nuclear envelope|nucleoplasm|endoplasmic reticulum membrane|lipid droplet|cytosol|plasma membrane|phospholipid metabolic process|platelet activating factor biosynthetic process|inflammatory response|parturition|O-acyltransferase activity|phospholipase A1 activity|membrane|viral process|arachidonic acid metabolic process|mitochondrial membrane|intracellular signal transduction|phosphatidylinositol acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|glycerophospholipid catabolic process|calcium-dependent phospholipase A2 activity|calcium-independent phospholipase A2 activity|phosphatidyl phospholipase B activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|lipid droplet formation" "hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04010,hsa04014,hsa04072,hsa04217,hsa04270,hsa04370,hsa04611,hsa04664,hsa04666,hsa04724,hsa04726,hsa04730,hsa04750,hsa04912,hsa04913,hsa04921,hsa05231" Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|MAPK signaling pathway|Ras signaling pathway|Phospholipase D signaling pathway|Necroptosis|Vascular smooth muscle contraction|VEGF signaling pathway|Platelet activation|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Glutamatergic synapse|Serotonergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Ovarian steroidogenesis|Oxytocin signaling pathway|Choline metabolism in cancer PLA2G6 110.8046929 120.6880104 100.9213754 0.836217078 -0.258050587 0.577531255 1 1.877812624 1.543982827 8398 phospholipase A2 group VI "GO:0003847,GO:0004622,GO:0004623,GO:0005515,GO:0005516,GO:0005615,GO:0005739,GO:0005829,GO:0005886,GO:0006935,GO:0016021,GO:0016290,GO:0016787,GO:0019731,GO:0031143,GO:0032049,GO:0034451,GO:0034638,GO:0035774,GO:0035965,GO:0036151,GO:0036152,GO:0038096,GO:0042802,GO:0046338,GO:0046469,GO:0046473,GO:0047499,GO:0102545,GO:0102567,GO:0102568,GO:0102991" "1-alkyl-2-acetylglycerophosphocholine esterase activity|lysophospholipase activity|phospholipase A2 activity|protein binding|calmodulin binding|extracellular space|mitochondrion|cytosol|plasma membrane|chemotaxis|integral component of membrane|palmitoyl-CoA hydrolase activity|hydrolase activity|antibacterial humoral response|pseudopodium|cardiolipin biosynthetic process|centriolar satellite|phosphatidylcholine catabolic process|positive regulation of insulin secretion involved in cellular response to glucose stimulus|cardiolipin acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|Fc-gamma receptor signaling pathway involved in phagocytosis|identical protein binding|phosphatidylethanolamine catabolic process|platelet activating factor metabolic process|phosphatidic acid metabolic process|calcium-independent phospholipase A2 activity|phosphatidyl phospholipase B activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|myristoyl-CoA hydrolase activity" "hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04014,hsa04270,hsa04666,hsa04750" Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|Ras signaling pathway|Vascular smooth muscle contraction|Fc gamma R-mediated phagocytosis|Inflammatory mediator regulation of TRP channels PLA2G7 2.561405743 4.161655531 0.961155956 0.230955193 -2.11431511 0.482263142 1 0.057974395 0.013165433 7941 phospholipase A2 group VII "GO:0003847,GO:0005543,GO:0005576,GO:0005737,GO:0016788,GO:0034362,GO:0034364,GO:0034374,GO:0034440,GO:0034441,GO:0034638,GO:0046469,GO:0047499,GO:0050729,GO:0062234,GO:0090026" "1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding|extracellular region|cytoplasm|hydrolase activity, acting on ester bonds|low-density lipoprotein particle|high-density lipoprotein particle|low-density lipoprotein particle remodeling|lipid oxidation|plasma lipoprotein particle oxidation|phosphatidylcholine catabolic process|platelet activating factor metabolic process|calcium-independent phospholipase A2 activity|positive regulation of inflammatory response|platelet activating factor catabolic process|positive regulation of monocyte chemotaxis" hsa00565 Ether lipid metabolism PLA2R1 576.7741757 595.1167409 558.4316104 0.938356413 -0.091792093 0.733966589 1 2.001026127 1.846255339 22925 phospholipase A2 receptor 1 "GO:0001816,GO:0005576,GO:0005886,GO:0006898,GO:0009986,GO:0016021,GO:0030246,GO:0038023,GO:0043235,GO:0043274,GO:0043517,GO:0072593,GO:0090238,GO:0090399,GO:0090403,GO:1900138,GO:1900139,GO:1904635" "cytokine production|extracellular region|plasma membrane|receptor-mediated endocytosis|cell surface|integral component of membrane|carbohydrate binding|signaling receptor activity|receptor complex|phospholipase binding|positive regulation of DNA damage response, signal transduction by p53 class mediator|reactive oxygen species metabolic process|positive regulation of arachidonic acid secretion|replicative senescence|oxidative stress-induced premature senescence|negative regulation of phospholipase A2 activity|negative regulation of arachidonic acid secretion|positive regulation of glomerular visceral epithelial cell apoptotic process" "hsa04145,hsa05152" Phagosome|Tuberculosis PLAA 1405.047921 1396.235431 1413.860411 1.012623216 0.018097465 0.942938505 1 11.97020382 11.91847263 9373 phospholipase A2 activating protein "GO:0005515,GO:0005634,GO:0005737,GO:0006644,GO:0006693,GO:0006954,GO:0007165,GO:0007399,GO:0010992,GO:0016005,GO:0016236,GO:0032430,GO:0043130,GO:0043161,GO:0043162,GO:0045202,GO:0070062,GO:0071222,GO:1900045,GO:1903423,GO:1903861,GO:2001224" protein binding|nucleus|cytoplasm|phospholipid metabolic process|prostaglandin metabolic process|inflammatory response|signal transduction|nervous system development|ubiquitin recycling|phospholipase A2 activator activity|macroautophagy|positive regulation of phospholipase A2 activity|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|synapse|extracellular exosome|cellular response to lipopolysaccharide|negative regulation of protein K63-linked ubiquitination|positive regulation of synaptic vesicle recycling|positive regulation of dendrite extension|positive regulation of neuron migration hsa04141 Protein processing in endoplasmic reticulum PLAAT3 581.9517074 567.025566 596.8778487 1.052647155 0.074021929 0.785085613 1 22.21814413 22.99650194 11145 phospholipase A and acyltransferase 3 "GO:0004623,GO:0005515,GO:0005575,GO:0005737,GO:0005777,GO:0005778,GO:0005783,GO:0005829,GO:0005886,GO:0006641,GO:0006644,GO:0007031,GO:0008654,GO:0008970,GO:0009617,GO:0016021,GO:0016032,GO:0016042,GO:0016410,GO:0036149,GO:0036150,GO:0036151,GO:0036152,GO:0045786,GO:0046485,GO:0048471,GO:0052739,GO:0052740,GO:0070292,GO:0102567,GO:0102568,GO:1904177" "phospholipase A2 activity|protein binding|cellular_component|cytoplasm|peroxisome|peroxisomal membrane|endoplasmic reticulum|cytosol|plasma membrane|triglyceride metabolic process|phospholipid metabolic process|peroxisome organization|phospholipid biosynthetic process|phospholipase A1 activity|response to bacterium|integral component of membrane|viral process|lipid catabolic process|N-acyltransferase activity|phosphatidylinositol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|negative regulation of cell cycle|ether lipid metabolic process|perinuclear region of cytoplasm|phosphatidylserine 1-acylhydrolase activity|1-acyl-2-lysophosphatidylserine acylhydrolase activity|N-acylphosphatidylethanolamine metabolic process|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|regulation of adipose tissue development" "hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04014,hsa04923" Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|Ras signaling pathway|Regulation of lipolysis in adipocytes PLAAT4 27.85843147 37.45489978 18.26196316 0.487572074 -1.036312598 0.167164999 1 2.637070134 1.264246273 5920 phospholipase A and acyltransferase 4 "GO:0004623,GO:0005515,GO:0005737,GO:0005829,GO:0006644,GO:0008285,GO:0008970,GO:0016020,GO:0016021,GO:0016042,GO:0016410,GO:0036152,GO:0045618,GO:0052739,GO:0052740,GO:0070292,GO:0102567,GO:0102568,GO:0150074" "phospholipase A2 activity|protein binding|cytoplasm|cytosol|phospholipid metabolic process|negative regulation of cell population proliferation|phospholipase A1 activity|membrane|integral component of membrane|lipid catabolic process|N-acyltransferase activity|phosphatidylethanolamine acyl-chain remodeling|positive regulation of keratinocyte differentiation|phosphatidylserine 1-acylhydrolase activity|1-acyl-2-lysophosphatidylserine acylhydrolase activity|N-acylphosphatidylethanolamine metabolic process|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|positive regulation of protein-glutamine gamma-glutamyltransferase activity" PLAC1 162.7071145 120.6880104 204.7262186 1.696326072 0.762413515 0.052932811 1 4.028078361 6.718594442 10761 placenta enriched 1 "GO:0001890,GO:0003674,GO:0005575,GO:0005576" placenta development|molecular_function|cellular_component|extracellular region PLAC8 68.01877597 57.22276355 78.81478839 1.377332787 0.461877181 0.396265424 1 0.910788464 1.233467144 51316 placenta associated 8 "GO:0003682,GO:0005576,GO:0008284,GO:0009409,GO:0035578,GO:0040015,GO:0042742,GO:0043066,GO:0043312,GO:0045944,GO:0050873,GO:0120162" chromatin binding|extracellular region|positive regulation of cell population proliferation|response to cold|azurophil granule lumen|negative regulation of multicellular organism growth|defense response to bacterium|negative regulation of apoptotic process|neutrophil degranulation|positive regulation of transcription by RNA polymerase II|brown fat cell differentiation|positive regulation of cold-induced thermogenesis PLAC8L1 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.041467496 0.056501239 153770 PLAC8 like 1 PLAG1 819.2125751 727.249304 911.1758463 1.252907141 0.325279494 0.195023939 1 5.182528872 6.384572065 5324 PLAG1 zinc finger "GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005654,GO:0005813,GO:0005829,GO:0006351,GO:0006355,GO:0010629,GO:0016607,GO:0022612,GO:0035264,GO:0045944,GO:0046872,GO:0060252,GO:0060736" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleoplasm|centrosome|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of gene expression|nuclear speck|gland morphogenesis|multicellular organism growth|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of glial cell proliferation|prostate gland growth" zf-C2H2 PLAGL1 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.027253299 5325 PLAG1 like zinc finger 1 "GO:0000122,GO:0000977,GO:0000978,GO:0001227,GO:0001228,GO:0003677,GO:0005515,GO:0005654,GO:0005794,GO:0006357,GO:0006915,GO:0006977,GO:0007050,GO:0016604,GO:0043231,GO:0045944,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|protein binding|nucleoplasm|Golgi apparatus|regulation of transcription by RNA polymerase II|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|cell cycle arrest|nuclear body|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|metal ion binding" PLAGL2 908.880669 1024.807674 792.9536637 0.773758514 -0.370044715 0.135686895 1 8.218197155 6.252492441 5326 PLAG1 like zinc finger 2 "GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0006351,GO:0006357,GO:0006629,GO:0009791,GO:0034378,GO:0043565,GO:0045944,GO:0046872,GO:2001244" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|transcription, DNA-templated|regulation of transcription by RNA polymerase II|lipid metabolic process|post-embryonic development|chylomicron assembly|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of intrinsic apoptotic signaling pathway" PLAT 10040.0033 6340.282201 13739.72439 2.1670525 1.115734105 1.15E-05 0.005806819 110.5059465 235.4649448 5327 "plasminogen activator, tissue type" "GO:0004252,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0006464,GO:0006508,GO:0007596,GO:0009986,GO:0014909,GO:0031639,GO:0042730,GO:0045861,GO:0048008,GO:0051219,GO:0062023,GO:0070062" serine-type endopeptidase activity|signaling receptor binding|protein binding|extracellular region|extracellular space|cytoplasm|cellular protein modification process|proteolysis|blood coagulation|cell surface|smooth muscle cell migration|plasminogen activation|fibrinolysis|negative regulation of proteolysis|platelet-derived growth factor receptor signaling pathway|phosphoprotein binding|collagen-containing extracellular matrix|extracellular exosome "hsa04371,hsa04610,hsa05202,hsa05215,hsa05418" Apelin signaling pathway|Complement and coagulation cascades|Transcriptional misregulation in cancer|Prostate cancer|Fluid shear stress and atherosclerosis PLAU 9979.07991 10241.83426 9716.325559 0.948689982 -0.075991382 0.762521702 1 222.5520647 207.5998908 5328 "plasminogen activator, urokinase" "GO:0001666,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0005925,GO:0006508,GO:0006935,GO:0007165,GO:0007596,GO:0009986,GO:0010469,GO:0014909,GO:0014910,GO:0030335,GO:0031639,GO:0033628,GO:0035579,GO:0042127,GO:0042730,GO:0043312,GO:0061041,GO:0070062,GO:0070821,GO:2000097" response to hypoxia|serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|plasma membrane|focal adhesion|proteolysis|chemotaxis|signal transduction|blood coagulation|cell surface|regulation of signaling receptor activity|smooth muscle cell migration|regulation of smooth muscle cell migration|positive regulation of cell migration|plasminogen activation|regulation of cell adhesion mediated by integrin|specific granule membrane|regulation of cell population proliferation|fibrinolysis|neutrophil degranulation|regulation of wound healing|extracellular exosome|tertiary granule membrane|regulation of smooth muscle cell-matrix adhesion "hsa04064,hsa04610,hsa05202,hsa05205,hsa05206,hsa05215" NF-kappa B signaling pathway|Complement and coagulation cascades|Transcriptional misregulation in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Prostate cancer PLAUR 2905.708779 2350.294961 3461.122598 1.472633289 0.558398219 0.018505267 0.781047912 39.90802495 57.78645157 5329 "plasminogen activator, urokinase receptor" "GO:0001934,GO:0005102,GO:0005515,GO:0005576,GO:0005788,GO:0005789,GO:0005886,GO:0005887,GO:0005925,GO:0006935,GO:0007165,GO:0007596,GO:0009986,GO:0016021,GO:0019898,GO:0019899,GO:0019904,GO:0030162,GO:0030377,GO:0031225,GO:0034112,GO:0035579,GO:0038023,GO:0038195,GO:0042730,GO:0043066,GO:0043312,GO:0043388,GO:0045742,GO:0071438,GO:0090200,GO:2001243,GO:2001268" positive regulation of protein phosphorylation|signaling receptor binding|protein binding|extracellular region|endoplasmic reticulum lumen|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|focal adhesion|chemotaxis|signal transduction|blood coagulation|cell surface|integral component of membrane|extrinsic component of membrane|enzyme binding|protein domain specific binding|regulation of proteolysis|urokinase plasminogen activator receptor activity|anchored component of membrane|positive regulation of homotypic cell-cell adhesion|specific granule membrane|signaling receptor activity|urokinase plasminogen activator signaling pathway|fibrinolysis|negative regulation of apoptotic process|neutrophil degranulation|positive regulation of DNA binding|positive regulation of epidermal growth factor receptor signaling pathway|invadopodium membrane|positive regulation of release of cytochrome c from mitochondria|negative regulation of intrinsic apoptotic signaling pathway|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway "hsa04610,hsa05205" Complement and coagulation cascades|Proteoglycans in cancer PLB1 13.97135991 13.52538047 14.41733934 1.065947044 0.092135768 1 1 0.064305096 0.067398805 151056 phospholipase B1 "GO:0001523,GO:0004620,GO:0004622,GO:0004623,GO:0004806,GO:0005886,GO:0006644,GO:0016021,GO:0016324,GO:0031526,GO:0036151,GO:0042572,GO:0050253,GO:0102545,GO:0102567,GO:0102568,GO:2000344" "retinoid metabolic process|phospholipase activity|lysophospholipase activity|phospholipase A2 activity|triglyceride lipase activity|plasma membrane|phospholipid metabolic process|integral component of membrane|apical plasma membrane|brush border membrane|phosphatidylcholine acyl-chain remodeling|retinol metabolic process|retinyl-palmitate esterase activity|phosphatidyl phospholipase B activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|positive regulation of acrosome reaction" "hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04977" Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|Vitamin digestion and absorption PLBD1 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.084987209 0.102932188 79887 phospholipase B domain containing 1 "GO:0004620,GO:0005576,GO:0005615,GO:0005764,GO:0005829,GO:0006644,GO:0009395,GO:0036149,GO:0036151,GO:0036152" phospholipase activity|extracellular region|extracellular space|lysosome|cytosol|phospholipid metabolic process|phospholipid catabolic process|phosphatidylinositol acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling PLBD2 1223.831009 1294.27487 1153.387147 0.891145439 -0.16626719 0.492697975 1 13.94570382 12.21969046 196463 phospholipase B domain containing 2 "GO:0004620,GO:0005515,GO:0005576,GO:0009395,GO:0043202,GO:0070062" phospholipase activity|protein binding|extracellular region|phospholipid catabolic process|lysosomal lumen|extracellular exosome PLCB1 293.0519582 249.6993318 336.4045846 1.347238625 0.430005406 0.175237911 1 1.849291481 2.44974609 23236 phospholipase C beta 1 "GO:0000086,GO:0000785,GO:0004435,GO:0004629,GO:0005096,GO:0005509,GO:0005515,GO:0005516,GO:0005521,GO:0005546,GO:0005634,GO:0005737,GO:0005829,GO:0007165,GO:0007186,GO:0007213,GO:0007215,GO:0007223,GO:0007613,GO:0008277,GO:0016042,GO:0016607,GO:0019899,GO:0021987,GO:0031965,GO:0032735,GO:0032991,GO:0035722,GO:0035723,GO:0040019,GO:0042802,GO:0043547,GO:0043647,GO:0045444,GO:0045663,GO:0045892,GO:0045893,GO:0046330,GO:0046488,GO:0048009,GO:0048015,GO:0048639,GO:0060466,GO:0070062,GO:0070498,GO:0080154,GO:0098794,GO:0098978,GO:0098982,GO:0099170,GO:0099178,GO:1900087,GO:1903140,GO:2000344,GO:2000438,GO:2000560" "G2/M transition of mitotic cell cycle|chromatin|phosphatidylinositol phospholipase C activity|phospholipase C activity|GTPase activator activity|calcium ion binding|protein binding|calmodulin binding|lamin binding|phosphatidylinositol-4,5-bisphosphate binding|nucleus|cytoplasm|cytosol|signal transduction|G protein-coupled receptor signaling pathway|G protein-coupled acetylcholine receptor signaling pathway|glutamate receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|memory|regulation of G protein-coupled receptor signaling pathway|lipid catabolic process|nuclear speck|enzyme binding|cerebral cortex development|nuclear membrane|positive regulation of interleukin-12 production|protein-containing complex|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|positive regulation of embryonic development|identical protein binding|positive regulation of GTPase activity|inositol phosphate metabolic process|fat cell differentiation|positive regulation of myoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of JNK cascade|phosphatidylinositol metabolic process|insulin-like growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of developmental growth|activation of meiosis involved in egg activation|extracellular exosome|interleukin-1-mediated signaling pathway|regulation of fertilization|postsynapse|glutamatergic synapse|GABA-ergic synapse|postsynaptic modulation of chemical synaptic transmission|regulation of retrograde trans-synaptic signaling by endocanabinoid|positive regulation of G1/S transition of mitotic cell cycle|regulation of establishment of endothelial barrier|positive regulation of acrosome reaction|negative regulation of monocyte extravasation|positive regulation of CD24 production" "hsa00562,hsa04015,hsa04020,hsa04022,hsa04062,hsa04070,hsa04071,hsa04072,hsa04261,hsa04270,hsa04310,hsa04371,hsa04540,hsa04611,hsa04621,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04742,hsa04750,hsa04911,hsa04912,hsa04915,hsa04916,hsa04918,hsa04919,hsa04921,hsa04922,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04929,hsa04933,hsa04934,hsa04935,hsa04961,hsa04970,hsa04971,hsa04972,hsa04973,hsa05010,hsa05016,hsa05017,hsa05022,hsa05131,hsa05142,hsa05143,hsa05146,hsa05163,hsa05200" "Inositol phosphate metabolism|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Chemokine signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Alzheimer disease|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis|Chagas disease|African trypanosomiasis|Amoebiasis|Human cytomegalovirus infection|Pathways in cancer" PLCB2 4.483717655 4.161655531 4.80577978 1.154775965 0.207612985 1 1 0.035759122 0.040602779 5330 phospholipase C beta 2 "GO:0004435,GO:0004629,GO:0005509,GO:0005515,GO:0005829,GO:0006644,GO:0007186,GO:0007202,GO:0007223,GO:0016042,GO:0043647,GO:0046488,GO:0048015,GO:0050913" "phosphatidylinositol phospholipase C activity|phospholipase C activity|calcium ion binding|protein binding|cytosol|phospholipid metabolic process|G protein-coupled receptor signaling pathway|activation of phospholipase C activity|Wnt signaling pathway, calcium modulating pathway|lipid catabolic process|inositol phosphate metabolic process|phosphatidylinositol metabolic process|phosphatidylinositol-mediated signaling|sensory perception of bitter taste" "hsa00562,hsa04015,hsa04020,hsa04022,hsa04062,hsa04070,hsa04071,hsa04072,hsa04261,hsa04270,hsa04310,hsa04371,hsa04540,hsa04611,hsa04621,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04742,hsa04750,hsa04911,hsa04912,hsa04915,hsa04916,hsa04918,hsa04919,hsa04921,hsa04922,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04929,hsa04933,hsa04934,hsa04935,hsa04961,hsa04970,hsa04971,hsa04972,hsa04973,hsa05010,hsa05016,hsa05017,hsa05022,hsa05131,hsa05142,hsa05143,hsa05146,hsa05163,hsa05200" "Inositol phosphate metabolism|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Chemokine signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Alzheimer disease|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis|Chagas disease|African trypanosomiasis|Amoebiasis|Human cytomegalovirus infection|Pathways in cancer" PLCB3 2104.799755 2116.201837 2093.397672 0.989224012 -0.015630835 0.949445896 1 21.30499956 20.72274858 5331 phospholipase C beta 3 "GO:0003073,GO:0004435,GO:0004629,GO:0005509,GO:0005515,GO:0005516,GO:0005634,GO:0005829,GO:0007186,GO:0007223,GO:0016020,GO:0016042,GO:0032991,GO:0043647,GO:0045296,GO:0046488,GO:0048015,GO:0099524" "regulation of systemic arterial blood pressure|phosphatidylinositol phospholipase C activity|phospholipase C activity|calcium ion binding|protein binding|calmodulin binding|nucleus|cytosol|G protein-coupled receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|membrane|lipid catabolic process|protein-containing complex|inositol phosphate metabolic process|cadherin binding|phosphatidylinositol metabolic process|phosphatidylinositol-mediated signaling|postsynaptic cytosol" "hsa00562,hsa04015,hsa04020,hsa04022,hsa04062,hsa04070,hsa04071,hsa04072,hsa04261,hsa04270,hsa04310,hsa04371,hsa04540,hsa04611,hsa04621,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04742,hsa04750,hsa04911,hsa04912,hsa04915,hsa04916,hsa04918,hsa04919,hsa04921,hsa04922,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04929,hsa04933,hsa04934,hsa04935,hsa04961,hsa04970,hsa04971,hsa04972,hsa04973,hsa05010,hsa05016,hsa05017,hsa05022,hsa05131,hsa05142,hsa05143,hsa05146,hsa05163,hsa05200" "Inositol phosphate metabolism|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Chemokine signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Alzheimer disease|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis|Chagas disease|African trypanosomiasis|Amoebiasis|Human cytomegalovirus infection|Pathways in cancer" PLCB4 927.1822612 1025.848088 828.5164341 0.807640472 -0.308214887 0.213214189 1 5.531739622 4.392896613 5332 phospholipase C beta 4 "GO:0004435,GO:0004629,GO:0005509,GO:0005515,GO:0005634,GO:0005790,GO:0005829,GO:0007186,GO:0014069,GO:0016042,GO:0030425,GO:0043647,GO:0048015,GO:0050804,GO:0098688,GO:0098978" phosphatidylinositol phospholipase C activity|phospholipase C activity|calcium ion binding|protein binding|nucleus|smooth endoplasmic reticulum|cytosol|G protein-coupled receptor signaling pathway|postsynaptic density|lipid catabolic process|dendrite|inositol phosphate metabolic process|phosphatidylinositol-mediated signaling|modulation of chemical synaptic transmission|parallel fiber to Purkinje cell synapse|glutamatergic synapse "hsa00562,hsa04015,hsa04020,hsa04022,hsa04062,hsa04070,hsa04071,hsa04072,hsa04261,hsa04270,hsa04310,hsa04371,hsa04540,hsa04611,hsa04621,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04742,hsa04750,hsa04911,hsa04912,hsa04915,hsa04916,hsa04918,hsa04919,hsa04921,hsa04922,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04929,hsa04933,hsa04934,hsa04935,hsa04961,hsa04970,hsa04971,hsa04972,hsa04973,hsa05010,hsa05016,hsa05017,hsa05022,hsa05131,hsa05142,hsa05143,hsa05146,hsa05163,hsa05200" "Inositol phosphate metabolism|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Chemokine signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Alzheimer disease|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis|Chagas disease|African trypanosomiasis|Amoebiasis|Human cytomegalovirus infection|Pathways in cancer" PLCD1 820.4461034 747.0171677 893.8750391 1.196592365 0.258931762 0.302624473 1 12.97751734 15.26894476 5333 phospholipase C delta 1 "GO:0001786,GO:0004435,GO:0005509,GO:0005515,GO:0005546,GO:0005737,GO:0005886,GO:0006644,GO:0016042,GO:0032794,GO:0043647,GO:0046488,GO:0048015,GO:0070062,GO:0070300" "phosphatidylserine binding|phosphatidylinositol phospholipase C activity|calcium ion binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|plasma membrane|phospholipid metabolic process|lipid catabolic process|GTPase activating protein binding|inositol phosphate metabolic process|phosphatidylinositol metabolic process|phosphatidylinositol-mediated signaling|extracellular exosome|phosphatidic acid binding" "hsa00562,hsa04020,hsa04070,hsa04919,hsa04933,hsa05131" Inositol phosphate metabolism|Calcium signaling pathway|Phosphatidylinositol signaling system|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Shigellosis PLCD3 1281.708572 1274.507006 1288.910137 1.011300943 0.016212378 0.949847939 1 10.70308363 10.64291294 113026 phospholipase C delta 3 "GO:0001525,GO:0004435,GO:0005829,GO:0005886,GO:0016042,GO:0032154,GO:0042127,GO:0043647,GO:0046872,GO:0048015,GO:0060716" angiogenesis|phosphatidylinositol phospholipase C activity|cytosol|plasma membrane|lipid catabolic process|cleavage furrow|regulation of cell population proliferation|inositol phosphate metabolic process|metal ion binding|phosphatidylinositol-mediated signaling|labyrinthine layer blood vessel development "hsa00562,hsa04020,hsa04070,hsa04919,hsa04933,hsa05131" Inositol phosphate metabolism|Calcium signaling pathway|Phosphatidylinositol signaling system|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Shigellosis PLCD4 38.91172496 37.45489978 40.36855015 1.0777909 0.108077311 0.909612468 1 0.442822145 0.469283216 84812 phospholipase C delta 4 "GO:0004435,GO:0005085,GO:0005509,GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0005829,GO:0005886,GO:0007340,GO:0016042,GO:0043647,GO:0046488,GO:0048015,GO:0050790" phosphatidylinositol phospholipase C activity|guanyl-nucleotide exchange factor activity|calcium ion binding|protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|plasma membrane|acrosome reaction|lipid catabolic process|inositol phosphate metabolic process|phosphatidylinositol metabolic process|phosphatidylinositol-mediated signaling|regulation of catalytic activity "hsa00562,hsa04020,hsa04070,hsa04919,hsa04933,hsa05131" Inositol phosphate metabolism|Calcium signaling pathway|Phosphatidylinositol signaling system|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Shigellosis PLCE1 123.0669769 101.9605605 144.1733934 1.414011385 0.499793736 0.252778167 1 0.396693717 0.551543038 51196 phospholipase C epsilon 1 "GO:0000139,GO:0000187,GO:0001558,GO:0004435,GO:0004629,GO:0005085,GO:0005515,GO:0005829,GO:0005886,GO:0006651,GO:0006940,GO:0007010,GO:0007173,GO:0007200,GO:0007204,GO:0007265,GO:0007507,GO:0008277,GO:0010592,GO:0016042,GO:0019722,GO:0019899,GO:0030027,GO:0031267,GO:0032835,GO:0043647,GO:0045859,GO:0046578,GO:0046872,GO:0048015,GO:0048016" Golgi membrane|activation of MAPK activity|regulation of cell growth|phosphatidylinositol phospholipase C activity|phospholipase C activity|guanyl-nucleotide exchange factor activity|protein binding|cytosol|plasma membrane|diacylglycerol biosynthetic process|regulation of smooth muscle contraction|cytoskeleton organization|epidermal growth factor receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|Ras protein signal transduction|heart development|regulation of G protein-coupled receptor signaling pathway|positive regulation of lamellipodium assembly|lipid catabolic process|calcium-mediated signaling|enzyme binding|lamellipodium|small GTPase binding|glomerulus development|inositol phosphate metabolic process|regulation of protein kinase activity|regulation of Ras protein signal transduction|metal ion binding|phosphatidylinositol-mediated signaling|inositol phosphate-mediated signaling "hsa00562,hsa04014,hsa04015,hsa04020,hsa04024,hsa04070,hsa04919,hsa04933,hsa05131,hsa05205" Inositol phosphate metabolism|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Phosphatidylinositol signaling system|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Shigellosis|Proteoglycans in cancer PLCG1 4019.607662 4240.726986 3798.488338 0.895716313 -0.158886214 0.504940719 1 41.86455884 36.87127717 5335 phospholipase C gamma 1 "GO:0001701,GO:0001726,GO:0004435,GO:0004629,GO:0005168,GO:0005509,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0007165,GO:0007173,GO:0007202,GO:0007411,GO:0008180,GO:0009395,GO:0010634,GO:0010863,GO:0016032,GO:0016477,GO:0019722,GO:0019901,GO:0030027,GO:0030971,GO:0035254,GO:0038095,GO:0038096,GO:0042995,GO:0043536,GO:0043647,GO:0045766,GO:0046488,GO:0050429,GO:0050804,GO:0050852,GO:0050900,GO:0051281,GO:0071364,GO:0098685,GO:0098978,GO:1905564,GO:2000353" in utero embryonic development|ruffle|phosphatidylinositol phospholipase C activity|phospholipase C activity|neurotrophin TRKA receptor binding|calcium ion binding|protein binding|cytoplasm|cytosol|plasma membrane|cell-cell junction|signal transduction|epidermal growth factor receptor signaling pathway|activation of phospholipase C activity|axon guidance|COP9 signalosome|phospholipid catabolic process|positive regulation of epithelial cell migration|positive regulation of phospholipase C activity|viral process|cell migration|calcium-mediated signaling|protein kinase binding|lamellipodium|receptor tyrosine kinase binding|glutamate receptor binding|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|cell projection|positive regulation of blood vessel endothelial cell migration|inositol phosphate metabolic process|positive regulation of angiogenesis|phosphatidylinositol metabolic process|calcium-dependent phospholipase C activity|modulation of chemical synaptic transmission|T cell receptor signaling pathway|leukocyte migration|positive regulation of release of sequestered calcium ion into cytosol|cellular response to epidermal growth factor stimulus|Schaffer collateral - CA1 synapse|glutamatergic synapse|positive regulation of vascular endothelial cell proliferation|positive regulation of endothelial cell apoptotic process "hsa00562,hsa01521,hsa04012,hsa04014,hsa04015,hsa04020,hsa04062,hsa04064,hsa04066,hsa04070,hsa04072,hsa04360,hsa04370,hsa04650,hsa04658,hsa04659,hsa04660,hsa04664,hsa04666,hsa04670,hsa04722,hsa04750,hsa04919,hsa04933,hsa04935,hsa05012,hsa05022,hsa05110,hsa05120,hsa05131,hsa05135,hsa05167,hsa05170,hsa05171,hsa05200,hsa05205,hsa05206,hsa05214,hsa05223,hsa05225,hsa05231,hsa05235" "Inositol phosphate metabolism|EGFR tyrosine kinase inhibitor resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|HIF-1 signaling pathway|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Axon guidance|VEGF signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Inflammatory mediator regulation of TRP channels|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Yersinia infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Glioma|Non-small cell lung cancer|Hepatocellular carcinoma|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" PLCG2 101.069216 130.0517353 72.0866967 0.554292463 -0.851280704 0.067723184 1 0.800902618 0.436505646 5336 phospholipase C gamma 2 "GO:0001784,GO:0002092,GO:0002223,GO:0002316,GO:0004435,GO:0004629,GO:0005515,GO:0005829,GO:0005886,GO:0006661,GO:0009395,GO:0010634,GO:0016055,GO:0019722,GO:0030168,GO:0030183,GO:0032237,GO:0032481,GO:0032496,GO:0032959,GO:0038095,GO:0038096,GO:0043069,GO:0043647,GO:0050852,GO:0050853,GO:0051209,GO:0070062,GO:0140031" phosphotyrosine residue binding|positive regulation of receptor internalization|stimulatory C-type lectin receptor signaling pathway|follicular B cell differentiation|phosphatidylinositol phospholipase C activity|phospholipase C activity|protein binding|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|phospholipid catabolic process|positive regulation of epithelial cell migration|Wnt signaling pathway|calcium-mediated signaling|platelet activation|B cell differentiation|activation of store-operated calcium channel activity|positive regulation of type I interferon production|response to lipopolysaccharide|inositol trisphosphate biosynthetic process|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|negative regulation of programmed cell death|inositol phosphate metabolic process|T cell receptor signaling pathway|B cell receptor signaling pathway|release of sequestered calcium ion into cytosol|extracellular exosome|phosphorylation-dependent protein binding "hsa00562,hsa01521,hsa04012,hsa04014,hsa04020,hsa04062,hsa04064,hsa04066,hsa04070,hsa04072,hsa04360,hsa04370,hsa04380,hsa04611,hsa04625,hsa04650,hsa04662,hsa04664,hsa04666,hsa04670,hsa04722,hsa04750,hsa04919,hsa04933,hsa04935,hsa05110,hsa05120,hsa05131,hsa05167,hsa05169,hsa05170,hsa05171,hsa05200,hsa05205,hsa05206,hsa05214,hsa05223,hsa05225" "Inositol phosphate metabolism|EGFR tyrosine kinase inhibitor resistance|ErbB signaling pathway|Ras signaling pathway|Calcium signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|HIF-1 signaling pathway|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Platelet activation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Inflammatory mediator regulation of TRP channels|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Glioma|Non-small cell lung cancer|Hepatocellular carcinoma" PLCH1 64.04520442 79.07145508 49.01895376 0.61993236 -0.689817281 0.209117519 1 0.341388094 0.208096059 23007 phospholipase C eta 1 "GO:0004435,GO:0005509,GO:0005737,GO:0005829,GO:0005886,GO:0016042,GO:0043231,GO:0043647,GO:0048015,GO:0050429" phosphatidylinositol phospholipase C activity|calcium ion binding|cytoplasm|cytosol|plasma membrane|lipid catabolic process|intracellular membrane-bounded organelle|inositol phosphate metabolic process|phosphatidylinositol-mediated signaling|calcium-dependent phospholipase C activity hsa00562 Inositol phosphate metabolism PLCL1 27.90309085 26.01034707 29.79583464 1.145537757 0.196025011 0.836744282 1 0.220582301 0.248457007 5334 phospholipase C like 1 (inactive) "GO:0004435,GO:0004629,GO:0005737,GO:0005886,GO:0006629,GO:0007214,GO:0032228,GO:0033135,GO:0035556,GO:0048015,GO:0050811,GO:0070679,GO:0120163,GO:1900122" "phosphatidylinositol phospholipase C activity|phospholipase C activity|cytoplasm|plasma membrane|lipid metabolic process|gamma-aminobutyric acid signaling pathway|regulation of synaptic transmission, GABAergic|regulation of peptidyl-serine phosphorylation|intracellular signal transduction|phosphatidylinositol-mediated signaling|GABA receptor binding|inositol 1,4,5 trisphosphate binding|negative regulation of cold-induced thermogenesis|positive regulation of receptor binding" hsa04727 GABAergic synapse PLCL2 326.2263156 313.1645787 339.2880525 1.083417716 0.115589587 0.713616577 1 1.224486628 1.304431141 23228 phospholipase C like 2 "GO:0002322,GO:0002337,GO:0004435,GO:0005515,GO:0005737,GO:0006629,GO:0007214,GO:0032228,GO:0033135,GO:0048015,GO:0050811,GO:0050859,GO:0070679,GO:0120163,GO:1900122" "B cell proliferation involved in immune response|B-1a B cell differentiation|phosphatidylinositol phospholipase C activity|protein binding|cytoplasm|lipid metabolic process|gamma-aminobutyric acid signaling pathway|regulation of synaptic transmission, GABAergic|regulation of peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|GABA receptor binding|negative regulation of B cell receptor signaling pathway|inositol 1,4,5 trisphosphate binding|negative regulation of cold-induced thermogenesis|positive regulation of receptor binding" PLCXD1-2 65.75489464 10.40413883 121.1056505 11.64014172 3.541036719 3.05E-08 2.98E-05 0.274332889 3.139838596 55344 phosphatidylinositol specific phospholipase C X domain containing 1 PLCXD2 124.6967949 132.1325631 117.2610266 0.887449875 -0.172262459 0.703927654 1 3.282901324 2.864658393 257068 phosphatidylinositol specific phospholipase C X domain containing 2 "GO:0005634,GO:0007165,GO:0008081,GO:0016042" nucleus|signal transduction|phosphoric diester hydrolase activity|lipid catabolic process PLD1 841.3330246 891.6346974 791.0313518 0.887169773 -0.172717884 0.491540757 1 6.756340345 5.893719105 5337 phospholipase D1 "GO:0000139,GO:0004630,GO:0005515,GO:0005765,GO:0005768,GO:0005789,GO:0005794,GO:0005886,GO:0006654,GO:0006935,GO:0007264,GO:0007265,GO:0016020,GO:0016042,GO:0016324,GO:0030139,GO:0031902,GO:0032534,GO:0035091,GO:0035579,GO:0043312,GO:0045727,GO:0048017,GO:0048471,GO:0048870,GO:0070290,GO:0070821,GO:0098693,GO:0098981" Golgi membrane|phospholipase D activity|protein binding|lysosomal membrane|endosome|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|phosphatidic acid biosynthetic process|chemotaxis|small GTPase mediated signal transduction|Ras protein signal transduction|membrane|lipid catabolic process|apical plasma membrane|endocytic vesicle|late endosome membrane|regulation of microvillus assembly|phosphatidylinositol binding|specific granule membrane|neutrophil degranulation|positive regulation of translation|inositol lipid-mediated signaling|perinuclear region of cytoplasm|cell motility|N-acylphosphatidylethanolamine-specific phospholipase D activity|tertiary granule membrane|regulation of synaptic vesicle cycle|cholinergic synapse "hsa00564,hsa00565,hsa04014,hsa04024,hsa04071,hsa04072,hsa04144,hsa04666,hsa04724,hsa04912,hsa04928,hsa05200,hsa05212,hsa05231" "Glycerophospholipid metabolism|Ether lipid metabolism|Ras signaling pathway|cAMP signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Endocytosis|Fc gamma R-mediated phagocytosis|Glutamatergic synapse|GnRH signaling pathway|Parathyroid hormone synthesis, secretion and action|Pathways in cancer|Pancreatic cancer|Choline metabolism in cancer" PLD2 921.6335919 981.1102913 862.1568925 0.878756344 -0.186464896 0.452878285 1 14.97713188 12.94101396 5338 phospholipase D2 "GO:0004630,GO:0005515,GO:0005789,GO:0005886,GO:0006654,GO:0007010,GO:0007264,GO:0016042,GO:0035091,GO:0036465,GO:0038096,GO:0048017,GO:0048870,GO:0070290,GO:0098793" phospholipase D activity|protein binding|endoplasmic reticulum membrane|plasma membrane|phosphatidic acid biosynthetic process|cytoskeleton organization|small GTPase mediated signal transduction|lipid catabolic process|phosphatidylinositol binding|synaptic vesicle recycling|Fc-gamma receptor signaling pathway involved in phagocytosis|inositol lipid-mediated signaling|cell motility|N-acylphosphatidylethanolamine-specific phospholipase D activity|presynapse "hsa00564,hsa00565,hsa04014,hsa04024,hsa04071,hsa04072,hsa04144,hsa04666,hsa04724,hsa04912,hsa04928,hsa05200,hsa05212,hsa05231" "Glycerophospholipid metabolism|Ether lipid metabolism|Ras signaling pathway|cAMP signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Endocytosis|Fc gamma R-mediated phagocytosis|Glutamatergic synapse|GnRH signaling pathway|Parathyroid hormone synthesis, secretion and action|Pathways in cancer|Pancreatic cancer|Choline metabolism in cancer" PLD3 1969.832799 1928.927338 2010.73826 1.042412651 0.059926498 0.80187356 1 39.29133849 40.27241518 23646 phospholipase D family member 3 "GO:0000139,GO:0002376,GO:0004630,GO:0005515,GO:0005765,GO:0005789,GO:0006259,GO:0006954,GO:0014902,GO:0016021,GO:0031901,GO:0031902,GO:0043202,GO:0045145,GO:0070062,GO:0090305,GO:1900015" Golgi membrane|immune system process|phospholipase D activity|protein binding|lysosomal membrane|endoplasmic reticulum membrane|DNA metabolic process|inflammatory response|myotube differentiation|integral component of membrane|early endosome membrane|late endosome membrane|lysosomal lumen|single-stranded DNA 5'-3' exodeoxyribonuclease activity|extracellular exosome|nucleic acid phosphodiester bond hydrolysis|regulation of cytokine production involved in inflammatory response "hsa00564,hsa00565" Glycerophospholipid metabolism|Ether lipid metabolism PLD6 103.204764 97.79890497 108.610623 1.110550502 0.151275001 0.76060439 1 1.654309924 1.806451752 201164 phospholipase D family member 6 "GO:0004519,GO:0005515,GO:0005741,GO:0006654,GO:0007286,GO:0008053,GO:0010636,GO:0016021,GO:0016042,GO:0030719,GO:0034587,GO:0035755,GO:0042803,GO:0043046,GO:0046872,GO:0051321,GO:0090305" endonuclease activity|protein binding|mitochondrial outer membrane|phosphatidic acid biosynthetic process|spermatid development|mitochondrial fusion|positive regulation of mitochondrial fusion|integral component of membrane|lipid catabolic process|P granule organization|piRNA metabolic process|cardiolipin hydrolase activity|protein homodimerization activity|DNA methylation involved in gamete generation|metal ion binding|meiotic cell cycle|nucleic acid phosphodiester bond hydrolysis PLEC 11956.27437 13083.20457 10829.34416 0.827728719 -0.272770082 0.286332062 1 41.56110608 33.82566156 5339 plectin "GO:0003723,GO:0003779,GO:0005198,GO:0005200,GO:0005515,GO:0005737,GO:0005829,GO:0005882,GO:0005886,GO:0005903,GO:0005925,GO:0008307,GO:0016020,GO:0016528,GO:0030056,GO:0030506,GO:0031581,GO:0042060,GO:0042383,GO:0043034,GO:0045104,GO:0045111,GO:0045296,GO:0048471,GO:0070062" RNA binding|actin binding|structural molecule activity|structural constituent of cytoskeleton|protein binding|cytoplasm|cytosol|intermediate filament|plasma membrane|brush border|focal adhesion|structural constituent of muscle|membrane|sarcoplasm|hemidesmosome|ankyrin binding|hemidesmosome assembly|wound healing|sarcolemma|costamere|intermediate filament cytoskeleton organization|intermediate filament cytoskeleton|cadherin binding|perinuclear region of cytoplasm|extracellular exosome PLEK2 1981.901354 1993.432999 1970.36971 0.988430366 -0.016788761 0.945708658 1 70.31451116 68.33799295 26499 pleckstrin 2 "GO:0005737,GO:0005856,GO:0005886,GO:0031258,GO:0031532,GO:0032266,GO:0035556,GO:0043325,GO:0080025,GO:0120034" "cytoplasm|cytoskeleton|plasma membrane|lamellipodium membrane|actin cytoskeleton reorganization|phosphatidylinositol-3-phosphate binding|intracellular signal transduction|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|positive regulation of plasma membrane bounded cell projection assembly" PLEKHA1 460.3314948 452.5800389 468.0829506 1.034254519 0.048591261 0.869221638 1 3.413903162 3.471760868 59338 pleckstrin homology domain containing A1 "GO:0001553,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006661,GO:0007283,GO:0008209,GO:0008210,GO:0008289,GO:0009791,GO:0014065,GO:0016020,GO:0030165,GO:0031529,GO:0032587,GO:0033327,GO:0035264,GO:0043325,GO:0045184,GO:0048008,GO:0048705,GO:0050853,GO:0051898,GO:0060021,GO:0060325,GO:0070062,GO:0070301" "luteinization|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|spermatogenesis|androgen metabolic process|estrogen metabolic process|lipid binding|post-embryonic development|phosphatidylinositol 3-kinase signaling|membrane|PDZ domain binding|ruffle organization|ruffle membrane|Leydig cell differentiation|multicellular organism growth|phosphatidylinositol-3,4-bisphosphate binding|establishment of protein localization|platelet-derived growth factor receptor signaling pathway|skeletal system morphogenesis|B cell receptor signaling pathway|negative regulation of protein kinase B signaling|roof of mouth development|face morphogenesis|extracellular exosome|cellular response to hydrogen peroxide" PLEKHA2 684.5815442 700.198543 668.9645454 0.955392655 -0.065834309 0.802765565 1 6.474066066 6.081772967 59339 pleckstrin homology domain containing A2 "GO:0001954,GO:0001968,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0006661,GO:0008289,GO:0016020,GO:0030165,GO:0032991,GO:0043236,GO:0043325" "positive regulation of cell-matrix adhesion|fibronectin binding|protein binding|nucleus|cytoplasm|plasma membrane|phosphatidylinositol biosynthetic process|lipid binding|membrane|PDZ domain binding|protein-containing complex|laminin binding|phosphatidylinositol-3,4-bisphosphate binding" PLEKHA3 582.2492318 524.3685969 640.1298667 1.220763163 0.287783334 0.277294606 1 2.007214766 2.409330827 65977 pleckstrin homology domain containing A3 "GO:0000139,GO:0005515,GO:0005794,GO:0005829,GO:0006661,GO:0008150,GO:0016020,GO:0035627,GO:0042802,GO:0070273,GO:0120009,GO:1902387,GO:1902388,GO:1902389" Golgi membrane|protein binding|Golgi apparatus|cytosol|phosphatidylinositol biosynthetic process|biological_process|membrane|ceramide transport|identical protein binding|phosphatidylinositol-4-phosphate binding|intermembrane lipid transfer|ceramide 1-phosphate binding|ceramide 1-phosphate transfer activity|ceramide 1-phosphate transport PLEKHA4 71.14001762 63.46524684 78.81478839 1.241857431 0.312499557 0.567113935 1 1.04893886 1.280834727 57664 pleckstrin homology domain containing A4 "GO:0005546,GO:0005737,GO:0005886,GO:0006661,GO:0031234,GO:0032266,GO:0043325,GO:0080025,GO:0090263,GO:2000096" "phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|plasma membrane|phosphatidylinositol biosynthetic process|extrinsic component of cytoplasmic side of plasma membrane|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|positive regulation of canonical Wnt signaling pathway|positive regulation of Wnt signaling pathway, planar cell polarity pathway" PLEKHA5 1738.804354 1806.1585 1671.450207 0.925417236 -0.111824125 0.638778498 1 7.583302618 6.900286928 54477 pleckstrin homology domain containing A5 "GO:0005515,GO:0005654,GO:0005829,GO:0008150,GO:0010314,GO:0014069,GO:0016020,GO:0032266,GO:0061458,GO:0070273,GO:0080025,GO:0098978" "protein binding|nucleoplasm|cytosol|biological_process|phosphatidylinositol-5-phosphate binding|postsynaptic density|membrane|phosphatidylinositol-3-phosphate binding|reproductive system development|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-3,5-bisphosphate binding|glutamatergic synapse" PLEKHA6 1203.299519 1360.861358 1045.73768 0.768438073 -0.379999094 0.116395665 1 4.32018735 3.264244145 22874 pleckstrin homology domain containing A6 GO:0005515 protein binding PLEKHA7 25.42094303 23.9295193 26.91236677 1.124651374 0.169477856 0.876198655 1 0.093695852 0.103611858 144100 pleckstrin homology domain containing A7 "GO:0005515,GO:0005654,GO:0005813,GO:0005829,GO:0005915,GO:0030054,GO:0044331,GO:0045218,GO:0046930,GO:0046931,GO:0070062,GO:0070097,GO:0090136" protein binding|nucleoplasm|centrosome|cytosol|zonula adherens|cell junction|cell-cell adhesion mediated by cadherin|zonula adherens maintenance|pore complex|pore complex assembly|extracellular exosome|delta-catenin binding|epithelial cell-cell adhesion PLEKHA8 819.6233416 801.1186896 838.1279936 1.04619703 0.065154579 0.799277247 1 2.773727266 2.853306442 84725 pleckstrin homology domain containing A8 "GO:0000139,GO:0005654,GO:0005794,GO:0005802,GO:0005829,GO:0006661,GO:0006869,GO:0015031,GO:0016020,GO:0017089,GO:0035621,GO:0035627,GO:0046836,GO:0051861,GO:0070273,GO:0097001,GO:0120009,GO:1902387,GO:1902388,GO:1902389" Golgi membrane|nucleoplasm|Golgi apparatus|trans-Golgi network|cytosol|phosphatidylinositol biosynthetic process|lipid transport|protein transport|membrane|glycolipid transfer activity|ER to Golgi ceramide transport|ceramide transport|glycolipid transport|glycolipid binding|phosphatidylinositol-4-phosphate binding|ceramide binding|intermembrane lipid transfer|ceramide 1-phosphate binding|ceramide 1-phosphate transfer activity|ceramide 1-phosphate transport PLEKHB1 64.41695634 50.98028025 77.85363244 1.527132296 0.610825049 0.267454578 1 0.877936063 1.318289307 58473 pleckstrin homology domain containing B1 "GO:0005515,GO:0005737,GO:0007275,GO:0007602,GO:0016021,GO:0045595" protein binding|cytoplasm|multicellular organism development|phototransduction|integral component of membrane|regulation of cell differentiation PLEKHB2 3725.001841 2877.784799 4572.218883 1.588798052 0.667935759 0.005095833 0.430157521 30.4424352 47.55752748 55041 pleckstrin homology domain containing B2 "GO:0005515,GO:0005547,GO:0016021,GO:0045595,GO:0055038" "protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|integral component of membrane|regulation of cell differentiation|recycling endosome membrane" PLEKHF1 77.69953262 84.27352449 71.12554074 0.843984409 -0.244711747 0.647561157 1 1.317762413 1.093560256 79156 pleckstrin homology and FYVE domain containing 1 "GO:0005515,GO:0005634,GO:0005764,GO:0005765,GO:0005768,GO:0006915,GO:0007032,GO:0010008,GO:0010314,GO:0010508,GO:0016050,GO:0032266,GO:0035091,GO:0046872,GO:0048471,GO:0070273,GO:0072659,GO:2001244" protein binding|nucleus|lysosome|lysosomal membrane|endosome|apoptotic process|endosome organization|endosome membrane|phosphatidylinositol-5-phosphate binding|positive regulation of autophagy|vesicle organization|phosphatidylinositol-3-phosphate binding|phosphatidylinositol binding|metal ion binding|perinuclear region of cytoplasm|phosphatidylinositol-4-phosphate binding|protein localization to plasma membrane|positive regulation of intrinsic apoptotic signaling pathway PLEKHF2 543.7036139 572.2276355 515.1795924 0.900305334 -0.151513728 0.575594079 1 10.52696904 9.31889348 79666 pleckstrin homology and FYVE domain containing 2 "GO:0005515,GO:0005783,GO:0015031,GO:0030133,GO:0031901,GO:0035091,GO:0046872" protein binding|endoplasmic reticulum|protein transport|transport vesicle|early endosome membrane|phosphatidylinositol binding|metal ion binding PLEKHG1 5.003924597 5.202069413 4.80577978 0.923820772 -0.11431511 1 1 0.036722868 0.033357654 57480 pleckstrin homology and RhoGEF domain containing G1 "GO:0005654,GO:0050790" nucleoplasm|regulation of catalytic activity PLEKHG2 767.9687546 782.3912397 753.5462695 0.963132294 -0.054194117 0.835008343 1 4.991605797 4.727128456 64857 pleckstrin homology and RhoGEF domain containing G2 "GO:0005515,GO:0005829,GO:0007186,GO:0030833,GO:0043065,GO:0050790,GO:0051056" protein binding|cytosol|G protein-coupled receptor signaling pathway|regulation of actin filament polymerization|positive regulation of apoptotic process|regulation of catalytic activity|regulation of small GTPase mediated signal transduction PLEKHG3 1950.936158 2013.200863 1888.671454 0.938143574 -0.092119364 0.698509208 1 11.84051465 10.92222368 26030 pleckstrin homology and RhoGEF domain containing G3 GO:0050790 regulation of catalytic activity PLEKHG4 6.123596406 9.363724944 2.883467868 0.307940257 -1.699277611 0.271781165 1 0.09703394 0.029380644 25894 pleckstrin homology and RhoGEF domain containing G4 "GO:0005085,GO:0005515,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|regulation of catalytic activity PLEKHG5 1710.33824 1487.791852 1932.884628 1.299163337 0.377582825 0.111848285 1 13.01224463 16.62214835 57449 pleckstrin homology and RhoGEF domain containing G5 "GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0007186,GO:0007266,GO:0030027,GO:0030139,GO:0030424,GO:0035767,GO:0043065,GO:0043123,GO:0043542,GO:0048471,GO:0050790,GO:0051056" cytoplasm|cytosol|plasma membrane|cell-cell junction|G protein-coupled receptor signaling pathway|Rho protein signal transduction|lamellipodium|endocytic vesicle|axon|endothelial cell chemotaxis|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|endothelial cell migration|perinuclear region of cytoplasm|regulation of catalytic activity|regulation of small GTPase mediated signal transduction hsa05200 Pathways in cancer PLEKHH1 315.7429188 290.2754733 341.2103644 1.175470874 0.233238793 0.454925547 1 1.915838301 2.21432775 57475 "pleckstrin homology, MyTH4 and FERM domain containing H1" GO:0005856 cytoskeleton PLEKHH2 603.8702104 536.8535634 670.8868573 1.249664532 0.321540861 0.221233775 1 3.847306027 4.727389165 130271 "pleckstrin homology, MyTH4 and FERM domain containing H2" "GO:0003779,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0016604,GO:0030027,GO:0030835,GO:0030864,GO:0042802" actin binding|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|nuclear body|lamellipodium|negative regulation of actin filament depolymerization|cortical actin cytoskeleton|identical protein binding PLEKHH3 562.5700724 562.8639105 562.2762343 0.998955918 -0.001507079 1 1 8.646808406 8.493238869 79990 "pleckstrin homology, MyTH4 and FERM domain containing H3" "GO:0005615,GO:0005856,GO:0007165" extracellular space|cytoskeleton|signal transduction PLEKHJ1 498.4009507 493.1561804 503.6457209 1.02127022 0.030364643 0.919273579 1 12.94581356 12.99993542 55111 pleckstrin homology domain containing J1 "GO:0001881,GO:0005515,GO:0005769,GO:0005802,GO:0005829,GO:0007032,GO:0042147,GO:0055037" "receptor recycling|protein binding|early endosome|trans-Golgi network|cytosol|endosome organization|retrograde transport, endosome to Golgi|recycling endosome" PLEKHM1 1044.021232 1178.788929 909.2535344 0.771345499 -0.374550882 0.126055524 1 9.67396565 7.337103899 9842 pleckstrin homology and RUN domain containing M1 "GO:0005730,GO:0005765,GO:0006914,GO:0010008,GO:0015031,GO:0032418,GO:0035556,GO:0043231,GO:0045780,GO:0046872,GO:1900029" nucleolus|lysosomal membrane|autophagy|endosome membrane|protein transport|lysosome localization|intracellular signal transduction|intracellular membrane-bounded organelle|positive regulation of bone resorption|metal ion binding|positive regulation of ruffle assembly hsa05132 Salmonella infection PLEKHM2 2130.194931 2303.476336 1956.913526 0.849547918 -0.235232771 0.319958303 1 27.40354402 22.89105406 23207 pleckstrin homology and RUN domain containing M2 "GO:0005515,GO:0007030,GO:0010008,GO:0019894,GO:0032418,GO:0032880,GO:1903527" protein binding|Golgi organization|endosome membrane|kinesin binding|lysosome localization|regulation of protein localization|positive regulation of membrane tubulation hsa05132 Salmonella infection PLEKHM3 407.037029 428.6505196 385.4235384 0.899155654 -0.153357211 0.598769547 1 1.267314299 1.120444613 389072 pleckstrin homology domain containing M3 "GO:0005737,GO:0005794,GO:0005886,GO:0045445,GO:0046872" cytoplasm|Golgi apparatus|plasma membrane|myoblast differentiation|metal ion binding PLEKHN1 129.9831526 132.1325631 127.8337421 0.967465848 -0.047717361 0.930001521 1 1.820256077 1.731567043 84069 pleckstrin homology domain containing N1 "GO:0001666,GO:0001786,GO:0005515,GO:0005739,GO:0005856,GO:0005886,GO:0031966,GO:0043065,GO:0061158,GO:0070300,GO:1901612,GO:1901981" response to hypoxia|phosphatidylserine binding|protein binding|mitochondrion|cytoskeleton|plasma membrane|mitochondrial membrane|positive regulation of apoptotic process|3'-UTR-mediated mRNA destabilization|phosphatidic acid binding|cardiolipin binding|phosphatidylinositol phosphate binding PLEKHO1 370.597391 418.2463808 322.9484012 0.772148705 -0.373049378 0.206834799 1 8.25787667 6.269609883 51177 pleckstrin homology domain containing O1 "GO:0005515,GO:0005634,GO:0005737,GO:0007520,GO:0008360,GO:0032587,GO:0036195,GO:0051451,GO:0072673" protein binding|nucleus|cytoplasm|myoblast fusion|regulation of cell shape|ruffle membrane|muscle cell projection membrane|myoblast migration|lamellipodium morphogenesis PLEKHO2 454.1185796 466.1054194 442.1317398 0.948565971 -0.076179981 0.792043642 1 6.743071176 6.289215312 80301 pleckstrin homology domain containing O2 "GO:0005576,GO:0043312,GO:0071888,GO:1904813" extracellular region|neutrophil degranulation|macrophage apoptotic process|ficolin-1-rich granule lumen PLGLB2 3.923881751 2.080827765 5.766935736 2.771462315 1.470647391 0.503574097 1 0.036820276 0.100338407 5342 plasminogen like B2 "GO:0004252,GO:0005576,GO:0006508" serine-type endopeptidase activity|extracellular region|proteolysis PLGRKT 395.0427012 378.7106533 411.3747492 1.086250798 0.119357236 0.686911034 1 12.45292146 13.30063991 55848 plasminogen receptor with a C-terminal lysine "GO:0005515,GO:0005887,GO:0006935,GO:0006954,GO:0010756" protein binding|integral component of plasma membrane|chemotaxis|inflammatory response|positive regulation of plasminogen activation PLIN1 8.006279355 8.323311061 7.689247648 0.923820772 -0.11431511 1 1 0.150934357 0.137103017 5346 perilipin 1 "GO:0005783,GO:0005811,GO:0005829,GO:0006629,GO:0008289,GO:0016042" endoplasmic reticulum|lipid droplet|cytosol|lipid metabolic process|lipid binding|lipid catabolic process "hsa03320,hsa04371,hsa04714,hsa04923" PPAR signaling pathway|Apelin signaling pathway|Thermogenesis|Regulation of lipolysis in adipocytes PLIN2 2089.083376 1463.862333 2714.30442 1.854207434 0.89080265 0.000182316 0.056965773 34.66000099 63.19141311 123 perilipin 2 "GO:0005515,GO:0005576,GO:0005634,GO:0005783,GO:0005811,GO:0005829,GO:0005886,GO:0010890,GO:0014070,GO:0015909,GO:0019216,GO:0019915,GO:0042493" protein binding|extracellular region|nucleus|endoplasmic reticulum|lipid droplet|cytosol|plasma membrane|positive regulation of sequestering of triglyceride|response to organic cyclic compound|long-chain fatty acid transport|regulation of lipid metabolic process|lipid storage|response to drug hsa03320 PPAR signaling pathway PLIN3 2543.283787 2323.2442 2763.323373 1.189424415 0.250263595 0.289886059 1 55.5498535 64.96672067 10226 perilipin 3 "GO:0005515,GO:0005737,GO:0005768,GO:0005794,GO:0005811,GO:0005829,GO:0010008,GO:0010890,GO:0016020,GO:0016192,GO:0019915,GO:0030133,GO:0045296" protein binding|cytoplasm|endosome|Golgi apparatus|lipid droplet|cytosol|endosome membrane|positive regulation of sequestering of triglyceride|membrane|vesicle-mediated transport|lipid storage|transport vesicle|cadherin binding PLIN5 4.523346619 5.202069413 3.844623824 0.739056617 -0.436243205 0.933440272 1 0.112398738 0.081678984 440503 perilipin 5 "GO:0005515,GO:0005737,GO:0005739,GO:0005811,GO:0005829,GO:0010867,GO:0010884,GO:0010890,GO:0010897,GO:0019915,GO:0031999,GO:0032000,GO:0034389,GO:0035359,GO:0035473,GO:0042802,GO:0043231,GO:0051646,GO:0060192,GO:0060193,GO:2000378" protein binding|cytoplasm|mitochondrion|lipid droplet|cytosol|positive regulation of triglyceride biosynthetic process|positive regulation of lipid storage|positive regulation of sequestering of triglyceride|negative regulation of triglyceride catabolic process|lipid storage|negative regulation of fatty acid beta-oxidation|positive regulation of fatty acid beta-oxidation|lipid droplet organization|negative regulation of peroxisome proliferator activated receptor signaling pathway|lipase binding|identical protein binding|intracellular membrane-bounded organelle|mitochondrion localization|negative regulation of lipase activity|positive regulation of lipase activity|negative regulation of reactive oxygen species metabolic process hsa03320 PPAR signaling pathway PLK1 2860.871104 3204.474759 2517.267449 0.785547598 -0.348229401 0.141140158 1 79.17450384 61.15458649 5347 polo like kinase 1 "GO:0000070,GO:0000086,GO:0000122,GO:0000132,GO:0000278,GO:0000281,GO:0000287,GO:0000776,GO:0000785,GO:0000795,GO:0000922,GO:0000942,GO:0001578,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005814,GO:0005819,GO:0005829,GO:0005876,GO:0006468,GO:0006511,GO:0007062,GO:0007077,GO:0007094,GO:0007098,GO:0007346,GO:0008017,GO:0010389,GO:0010800,GO:0010997,GO:0015630,GO:0016301,GO:0016321,GO:0016567,GO:0018105,GO:0019901,GO:0030071,GO:0030496,GO:0031145,GO:0031648,GO:0032436,GO:0032465,GO:0034451,GO:0042802,GO:0043066,GO:0043393,GO:0045143,GO:0045184,GO:0045736,GO:0045862,GO:0051081,GO:0051233,GO:0051443,GO:0051726,GO:0070194,GO:0071168,GO:0072425,GO:0090435,GO:0097431,GO:0097711,GO:1900182,GO:1901673,GO:1901990,GO:1902749,GO:1904668,GO:1904776" mitotic sister chromatid segregation|G2/M transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|establishment of mitotic spindle orientation|mitotic cell cycle|mitotic cytokinesis|magnesium ion binding|kinetochore|chromatin|synaptonemal complex|spindle pole|condensed nuclear chromosome outer kinetochore|microtubule bundle formation|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|centriole|spindle|cytosol|spindle microtubule|protein phosphorylation|ubiquitin-dependent protein catabolic process|sister chromatid cohesion|mitotic nuclear envelope disassembly|mitotic spindle assembly checkpoint|centrosome cycle|regulation of mitotic cell cycle|microtubule binding|regulation of G2/M transition of mitotic cell cycle|positive regulation of peptidyl-threonine phosphorylation|anaphase-promoting complex binding|microtubule cytoskeleton|kinase activity|female meiosis chromosome segregation|protein ubiquitination|peptidyl-serine phosphorylation|protein kinase binding|regulation of mitotic metaphase/anaphase transition|midbody|anaphase-promoting complex-dependent catabolic process|protein destabilization|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of cytokinesis|centriolar satellite|identical protein binding|negative regulation of apoptotic process|regulation of protein binding|homologous chromosome segregation|establishment of protein localization|negative regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of proteolysis|nuclear envelope disassembly|spindle midzone|positive regulation of ubiquitin-protein transferase activity|regulation of cell cycle|synaptonemal complex disassembly|protein localization to chromatin|signal transduction involved in G2 DNA damage checkpoint|protein localization to nuclear envelope|mitotic spindle pole|ciliary basal body-plasma membrane docking|positive regulation of protein localization to nucleus|regulation of mitotic spindle assembly|regulation of mitotic cell cycle phase transition|regulation of cell cycle G2/M phase transition|positive regulation of ubiquitin protein ligase activity|regulation of protein localization to cell cortex "hsa04068,hsa04110,hsa04114,hsa04914" FoxO signaling pathway|Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation PLK2 7471.409082 6998.864189 7943.953976 1.135034737 0.182736451 0.456714492 1 134.0691021 149.6266775 10769 polo like kinase 2 "GO:0000082,GO:0000278,GO:0000785,GO:0000922,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0006468,GO:0006977,GO:0007052,GO:0007093,GO:0007265,GO:0007613,GO:0010508,GO:0016525,GO:0018105,GO:0030425,GO:0032092,GO:0032436,GO:0032465,GO:0032486,GO:0043008,GO:0043066,GO:0043123,GO:0044877,GO:0045732,GO:0046599,GO:0048167,GO:0060291,GO:0060292,GO:0061000,GO:0071866,GO:0090050,GO:2000773" "G1/S transition of mitotic cell cycle|mitotic cell cycle|chromatin|spindle pole|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|centrosome|centriole|cytosol|protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|mitotic spindle organization|mitotic cell cycle checkpoint|Ras protein signal transduction|memory|positive regulation of autophagy|negative regulation of angiogenesis|peptidyl-serine phosphorylation|dendrite|positive regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of cytokinesis|Rap protein signal transduction|ATP-dependent protein binding|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|protein-containing complex binding|positive regulation of protein catabolic process|regulation of centriole replication|regulation of synaptic plasticity|long-term synaptic potentiation|long-term synaptic depression|negative regulation of dendritic spine development|negative regulation of apoptotic process in bone marrow cell|positive regulation of cell migration involved in sprouting angiogenesis|negative regulation of cellular senescence" hsa04068 FoxO signaling pathway PLK3 692.6029148 671.0669543 714.1388753 1.064184238 0.08974794 0.730783071 1 15.30496153 16.01475293 1263 polo like kinase 3 "GO:0000082,GO:0000086,GO:0000122,GO:0000278,GO:0000302,GO:0000922,GO:0002039,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005795,GO:0005813,GO:0006468,GO:0006915,GO:0006970,GO:0006974,GO:0006977,GO:0007093,GO:0007113,GO:0009314,GO:0030425,GO:0031122,GO:0032465,GO:0043025,GO:0043066,GO:0043491,GO:0044819,GO:0051302,GO:0090166,GO:0090316,GO:1901796,GO:1904716,GO:2000777" "G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|mitotic cell cycle|response to reactive oxygen species|spindle pole|p53 binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|Golgi stack|centrosome|protein phosphorylation|apoptotic process|response to osmotic stress|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|mitotic cell cycle checkpoint|endomitotic cell cycle|response to radiation|dendrite|cytoplasmic microtubule organization|regulation of cytokinesis|neuronal cell body|negative regulation of apoptotic process|protein kinase B signaling|mitotic G1/S transition checkpoint|regulation of cell division|Golgi disassembly|positive regulation of intracellular protein transport|regulation of signal transduction by p53 class mediator|positive regulation of chaperone-mediated autophagy|positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia" "hsa04068,hsa04625,hsa05152" FoxO signaling pathway|C-type lectin receptor signaling pathway|Tuberculosis PLK4 974.1650465 1010.24188 938.088213 0.92857783 -0.106905258 0.6669941 1 12.9509374 11.82471531 10733 polo like kinase 4 "GO:0000086,GO:0000278,GO:0000922,GO:0001741,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005730,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0006468,GO:0007099,GO:0010389,GO:0032154,GO:0032465,GO:0042802,GO:0046601,GO:0060707,GO:0097711,GO:0098535,GO:0098536" G2/M transition of mitotic cell cycle|mitotic cell cycle|spindle pole|XY body|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleolus|cytoplasm|centrosome|centriole|cytosol|protein phosphorylation|centriole replication|regulation of G2/M transition of mitotic cell cycle|cleavage furrow|regulation of cytokinesis|identical protein binding|positive regulation of centriole replication|trophoblast giant cell differentiation|ciliary basal body-plasma membrane docking|de novo centriole assembly involved in multi-ciliated epithelial cell differentiation|deuterosome hsa04068 FoxO signaling pathway PLLP 14.57082478 16.64662212 12.49502743 0.750604377 -0.413875392 0.719526004 1 0.593453325 0.437994683 51090 plasmolipin "GO:0005515,GO:0006811,GO:0009611,GO:0016021,GO:0019911,GO:0042552,GO:0043218,GO:0045121" protein binding|ion transport|response to wounding|integral component of membrane|structural constituent of myelin sheath|myelination|compact myelin|membrane raft PLOD1 3268.588699 3335.566908 3201.610489 0.959839985 -0.059134181 0.8039985 1 57.1103867 53.89954724 5351 "procollagen-lysine,2-oxoglutarate 5-dioxygenase 1" "GO:0001666,GO:0005506,GO:0005515,GO:0005783,GO:0005789,GO:0006493,GO:0008475,GO:0008544,GO:0017185,GO:0018215,GO:0030867,GO:0031418,GO:0033823,GO:0055114,GO:0070062,GO:1902494" response to hypoxia|iron ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein O-linked glycosylation|procollagen-lysine 5-dioxygenase activity|epidermis development|peptidyl-lysine hydroxylation|protein phosphopantetheinylation|rough endoplasmic reticulum membrane|L-ascorbic acid binding|procollagen glucosyltransferase activity|oxidation-reduction process|extracellular exosome|catalytic complex hsa00310 Lysine degradation PLOD2 4302.084946 3998.310551 4605.859341 1.151951376 0.204079822 0.392654974 1 55.05224085 62.35629854 5352 "procollagen-lysine,2-oxoglutarate 5-dioxygenase 2" "GO:0001666,GO:0005506,GO:0005783,GO:0005789,GO:0006464,GO:0006493,GO:0008475,GO:0017185,GO:0018215,GO:0030867,GO:0031418,GO:0033823,GO:0046947,GO:0055114,GO:0070062" response to hypoxia|iron ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|cellular protein modification process|protein O-linked glycosylation|procollagen-lysine 5-dioxygenase activity|peptidyl-lysine hydroxylation|protein phosphopantetheinylation|rough endoplasmic reticulum membrane|L-ascorbic acid binding|procollagen glucosyltransferase activity|hydroxylysine biosynthetic process|oxidation-reduction process|extracellular exosome hsa00310 Lysine degradation PLOD3 1757.314766 1686.510904 1828.118628 1.083964903 0.116318045 0.625184489 1 31.90570268 34.00593443 8985 "procollagen-lysine,2-oxoglutarate 5-dioxygenase 3" "GO:0001701,GO:0001886,GO:0005506,GO:0005515,GO:0005615,GO:0005783,GO:0005788,GO:0005789,GO:0005791,GO:0005794,GO:0005802,GO:0006493,GO:0008104,GO:0008475,GO:0017185,GO:0018215,GO:0021915,GO:0030199,GO:0031418,GO:0032870,GO:0032963,GO:0033823,GO:0042311,GO:0046947,GO:0048730,GO:0050211,GO:0055114,GO:0060425,GO:0062023,GO:0070062,GO:0070831" in utero embryonic development|endothelial cell morphogenesis|iron ion binding|protein binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|rough endoplasmic reticulum|Golgi apparatus|trans-Golgi network|protein O-linked glycosylation|protein localization|procollagen-lysine 5-dioxygenase activity|peptidyl-lysine hydroxylation|protein phosphopantetheinylation|neural tube development|collagen fibril organization|L-ascorbic acid binding|cellular response to hormone stimulus|collagen metabolic process|procollagen glucosyltransferase activity|vasodilation|hydroxylysine biosynthetic process|epidermis morphogenesis|procollagen galactosyltransferase activity|oxidation-reduction process|lung morphogenesis|collagen-containing extracellular matrix|extracellular exosome|basement membrane assembly "hsa00310,hsa00514" Lysine degradation|Other types of O-glycan biosynthesis PLP2 6973.494355 6392.302895 7554.685814 1.181841026 0.241035987 0.323995694 1 309.2887189 359.4134458 5355 proteolipid protein 2 "GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0006811,GO:0006935,GO:0015075,GO:0016020,GO:0016021,GO:0019221,GO:0019956,GO:0034220" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|ion transport|chemotaxis|ion transmembrane transporter activity|membrane|integral component of membrane|cytokine-mediated signaling pathway|chemokine binding|ion transmembrane transport PLPBP 548.4898864 521.2473552 575.7324176 1.104528228 0.14343029 0.595895928 1 7.072975676 7.681573009 11212 pyridoxal phosphate binding protein "GO:0005622,GO:0005737,GO:0005829,GO:0008150,GO:0030170" intracellular anatomical structure|cytoplasm|cytosol|biological_process|pyridoxal phosphate binding PLPP1 356.661244 317.3262342 395.9962539 1.247915272 0.319519985 0.285944375 1 9.955977601 12.21631406 8611 phospholipid phosphatase 1 "GO:0000810,GO:0005515,GO:0005886,GO:0005887,GO:0005901,GO:0006644,GO:0006670,GO:0006672,GO:0007165,GO:0007205,GO:0008195,GO:0008285,GO:0016020,GO:0016324,GO:0019216,GO:0030148,GO:0030518,GO:0030521,GO:0042392,GO:0042577,GO:0045121,GO:0046839,GO:0070062,GO:0106235" diacylglycerol diphosphate phosphatase activity|protein binding|plasma membrane|integral component of plasma membrane|caveola|phospholipid metabolic process|sphingosine metabolic process|ceramide metabolic process|signal transduction|protein kinase C-activating G protein-coupled receptor signaling pathway|phosphatidate phosphatase activity|negative regulation of cell population proliferation|membrane|apical plasma membrane|regulation of lipid metabolic process|sphingolipid biosynthetic process|intracellular steroid hormone receptor signaling pathway|androgen receptor signaling pathway|sphingosine-1-phosphate phosphatase activity|lipid phosphatase activity|membrane raft|phospholipid dephosphorylation|extracellular exosome|ceramide-1-phosphate phosphatase activity "hsa00561,hsa00564,hsa00565,hsa00600,hsa04072,hsa04666,hsa04975,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Ether lipid metabolism|Sphingolipid metabolism|Phospholipase D signaling pathway|Fc gamma R-mediated phagocytosis|Fat digestion and absorption|Choline metabolism in cancer PLPP2 130.5379581 146.6983575 114.3775588 0.779678524 -0.359048699 0.404144598 1 5.336756453 4.091326456 8612 phospholipid phosphatase 2 "GO:0005515,GO:0005769,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0005901,GO:0006644,GO:0006670,GO:0006672,GO:0007165,GO:0008195,GO:0016021,GO:0030148,GO:0031901,GO:0042392,GO:0042577,GO:0046839,GO:0106235,GO:1902806" protein binding|early endosome|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|caveola|phospholipid metabolic process|sphingosine metabolic process|ceramide metabolic process|signal transduction|phosphatidate phosphatase activity|integral component of membrane|sphingolipid biosynthetic process|early endosome membrane|sphingosine-1-phosphate phosphatase activity|lipid phosphatase activity|phospholipid dephosphorylation|ceramide-1-phosphate phosphatase activity|regulation of cell cycle G1/S phase transition "hsa00561,hsa00564,hsa00565,hsa00600,hsa04072,hsa04666,hsa04975,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Ether lipid metabolism|Sphingolipid metabolism|Phospholipase D signaling pathway|Fc gamma R-mediated phagocytosis|Fat digestion and absorption|Choline metabolism in cancer PLPP3 315.1975598 351.6598923 278.7352272 0.792627289 -0.335285456 0.280167274 1 5.734018372 4.468886033 8613 phospholipid phosphatase 3 "GO:0000139,GO:0001933,GO:0005178,GO:0005515,GO:0005789,GO:0005794,GO:0005802,GO:0005886,GO:0005887,GO:0005912,GO:0006644,GO:0006670,GO:0006672,GO:0006890,GO:0007165,GO:0007229,GO:0008195,GO:0016020,GO:0016021,GO:0016323,GO:0030111,GO:0030148,GO:0033116,GO:0033631,GO:0034109,GO:0042392,GO:0042577,GO:0044328,GO:0044329,GO:0044330,GO:0045121,GO:0046839,GO:0050821,GO:0051091,GO:0060070,GO:0070971,GO:0106235" "Golgi membrane|negative regulation of protein phosphorylation|integrin binding|protein binding|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|plasma membrane|integral component of plasma membrane|adherens junction|phospholipid metabolic process|sphingosine metabolic process|ceramide metabolic process|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|signal transduction|integrin-mediated signaling pathway|phosphatidate phosphatase activity|membrane|integral component of membrane|basolateral plasma membrane|regulation of Wnt signaling pathway|sphingolipid biosynthetic process|endoplasmic reticulum-Golgi intermediate compartment membrane|cell-cell adhesion mediated by integrin|homotypic cell-cell adhesion|sphingosine-1-phosphate phosphatase activity|lipid phosphatase activity|canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration|canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt signaling pathway involved in positive regulation of wound healing|membrane raft|phospholipid dephosphorylation|protein stabilization|positive regulation of DNA-binding transcription factor activity|canonical Wnt signaling pathway|endoplasmic reticulum exit site|ceramide-1-phosphate phosphatase activity" "hsa00561,hsa00564,hsa00565,hsa00600,hsa04072,hsa04666,hsa04975,hsa05231" Glycerolipid metabolism|Glycerophospholipid metabolism|Ether lipid metabolism|Sphingolipid metabolism|Phospholipase D signaling pathway|Fc gamma R-mediated phagocytosis|Fat digestion and absorption|Choline metabolism in cancer PLPP5 405.8928195 385.9935505 425.7920885 1.103106744 0.141572402 0.628242175 1 4.294301931 4.657804911 84513 phospholipid phosphatase 5 "GO:0000810,GO:0005515,GO:0005737,GO:0005886,GO:0006644,GO:0008195,GO:0016021,GO:0046839" diacylglycerol diphosphate phosphatase activity|protein binding|cytoplasm|plasma membrane|phospholipid metabolic process|phosphatidate phosphatase activity|integral component of membrane|phospholipid dephosphorylation "hsa00561,hsa00564" Glycerolipid metabolism|Glycerophospholipid metabolism PLPP6 231.2951728 255.9418151 206.6485305 0.807404333 -0.308636766 0.372591242 1 4.606794021 3.657303898 403313 phospholipid phosphatase 6 "GO:0005515,GO:0005886,GO:0006695,GO:0016020,GO:0016021,GO:0016787,GO:0042392,GO:0042577,GO:0046839" protein binding|plasma membrane|cholesterol biosynthetic process|membrane|integral component of membrane|hydrolase activity|sphingosine-1-phosphate phosphatase activity|lipid phosphatase activity|phospholipid dephosphorylation PLPPR2 687.6933394 630.4908129 744.8958659 1.181453957 0.240563407 0.350122459 1 12.22679356 14.20366954 64748 phospholipid phosphatase related 2 "GO:0005515,GO:0005887,GO:0006644,GO:0007165,GO:0008195,GO:0042577,GO:0046839" protein binding|integral component of plasma membrane|phospholipid metabolic process|signal transduction|phosphatidate phosphatase activity|lipid phosphatase activity|phospholipid dephosphorylation PLRG1 1297.676471 1302.598181 1292.754761 0.992443241 -0.010943499 0.967265938 1 20.95787484 20.45144975 5356 pleiotropic regulator 1 "GO:0000398,GO:0000974,GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005662,GO:0016607,GO:0031965,GO:0034504,GO:0071007,GO:0071013,GO:0080008,GO:1900087" "mRNA splicing, via spliceosome|Prp19 complex|fibrillar center|protein binding|nucleus|nucleoplasm|DNA replication factor A complex|nuclear speck|nuclear membrane|protein localization to nucleus|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|Cul4-RING E3 ubiquitin ligase complex|positive regulation of G1/S transition of mitotic cell cycle" hsa03040 Spliceosome PLS1 767.2504029 776.1487565 758.3520493 0.977070495 -0.03346544 0.89994139 1 8.586573928 8.249297967 5357 plastin 1 "GO:0001951,GO:0005200,GO:0005509,GO:0005737,GO:0005884,GO:0005903,GO:0032420,GO:0032432,GO:0032532,GO:0040018,GO:0051015,GO:0051017,GO:0051639,GO:0060088,GO:0060121,GO:0070062,GO:1902896,GO:1903078,GO:1990357" intestinal D-glucose absorption|structural constituent of cytoskeleton|calcium ion binding|cytoplasm|actin filament|brush border|stereocilium|actin filament bundle|regulation of microvillus length|positive regulation of multicellular organism growth|actin filament binding|actin filament bundle assembly|actin filament network formation|auditory receptor cell stereocilium organization|vestibular receptor cell stereocilium organization|extracellular exosome|terminal web assembly|positive regulation of protein localization to plasma membrane|terminal web PLS3 11148.30282 10001.49865 12295.10699 1.229326465 0.297868095 0.240972255 1 139.8379883 169.0299167 5358 plastin 3 "GO:0005509,GO:0005737,GO:0005829,GO:0005884,GO:0005886,GO:0032432,GO:0051015,GO:0051017,GO:0051639,GO:0060348" calcium ion binding|cytoplasm|cytosol|actin filament|plasma membrane|actin filament bundle|actin filament binding|actin filament bundle assembly|actin filament network formation|bone development PLSCR1 706.7126689 738.6938567 674.7314811 0.913411524 -0.130663104 0.61258601 1 17.2528374 15.49523597 5359 phospholipid scramblase 1 "GO:0000287,GO:0001228,GO:0001618,GO:0003677,GO:0004518,GO:0005154,GO:0005509,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0005887,GO:0006659,GO:0006915,GO:0006953,GO:0008270,GO:0010288,GO:0010628,GO:0016020,GO:0017121,GO:0017124,GO:0017128,GO:0019899,GO:0030168,GO:0032791,GO:0033003,GO:0035456,GO:0042609,GO:0045071,GO:0045089,GO:0045121,GO:0045340,GO:0045944,GO:0046718,GO:0048471,GO:0050765,GO:0051607,GO:0060368,GO:0062023,GO:0070062,GO:0070782,GO:0090305,GO:1905820,GO:2000373" "magnesium ion binding|DNA-binding transcription activator activity, RNA polymerase II-specific|virus receptor activity|DNA binding|nuclease activity|epidermal growth factor receptor binding|calcium ion binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|Golgi apparatus|cytosol|plasma membrane|integral component of plasma membrane|phosphatidylserine biosynthetic process|apoptotic process|acute-phase response|zinc ion binding|response to lead ion|positive regulation of gene expression|membrane|plasma membrane phospholipid scrambling|SH3 domain binding|phospholipid scramblase activity|enzyme binding|platelet activation|lead ion binding|regulation of mast cell activation|response to interferon-beta|CD4 receptor binding|negative regulation of viral genome replication|positive regulation of innate immune response|membrane raft|mercury ion binding|positive regulation of transcription by RNA polymerase II|viral entry into host cell|perinuclear region of cytoplasm|negative regulation of phagocytosis|defense response to virus|regulation of Fc receptor mediated stimulatory signaling pathway|collagen-containing extracellular matrix|extracellular exosome|phosphatidylserine exposure on apoptotic cell surface|nucleic acid phosphodiester bond hydrolysis|positive regulation of chromosome separation|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity" PLSCR3 1111.798432 1040.413883 1183.182982 1.13722337 0.185515652 0.447392156 1 31.62014619 35.35744122 57048 phospholipid scramblase 3 "GO:0000287,GO:0005509,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005829,GO:0005886,GO:0006915,GO:0016021,GO:0017121,GO:0017124,GO:0017128,GO:0032049,GO:0032791,GO:0042593,GO:0042632,GO:0042981,GO:0043621,GO:0045340,GO:0048306,GO:0071222,GO:0090199" magnesium ion binding|calcium ion binding|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|cytosol|plasma membrane|apoptotic process|integral component of membrane|plasma membrane phospholipid scrambling|SH3 domain binding|phospholipid scramblase activity|cardiolipin biosynthetic process|lead ion binding|glucose homeostasis|cholesterol homeostasis|regulation of apoptotic process|protein self-association|mercury ion binding|calcium-dependent protein binding|cellular response to lipopolysaccharide|regulation of release of cytochrome c from mitochondria PLSCR4 206.5680438 199.7594655 213.3766222 1.068167767 0.095138256 0.80282366 1 2.211783305 2.323021466 57088 phospholipid scramblase 4 "GO:0005509,GO:0005515,GO:0005886,GO:0016021,GO:0017121,GO:0017124,GO:0017128,GO:0019899,GO:0042609,GO:0071222" calcium ion binding|protein binding|plasma membrane|integral component of membrane|plasma membrane phospholipid scrambling|SH3 domain binding|phospholipid scramblase activity|enzyme binding|CD4 receptor binding|cellular response to lipopolysaccharide PLTP 78.69528712 97.79890497 59.59166927 0.609328594 -0.714707651 0.160550175 1 2.590247053 1.551900688 5360 phospholipid transfer protein "GO:0005576,GO:0005615,GO:0005634,GO:0006629,GO:0006869,GO:0008035,GO:0008429,GO:0008525,GO:0008526,GO:0010189,GO:0010875,GO:0015914,GO:0015918,GO:0019992,GO:0030169,GO:0030317,GO:0031210,GO:0034189,GO:0034364,GO:0034375,GO:0035627,GO:0046836,GO:0070300,GO:0097001,GO:0120009,GO:0120014,GO:0120017,GO:0120019,GO:0120020,GO:0140337,GO:0140338,GO:0140339,GO:0140340,GO:1901611,GO:1904121,GO:1990050" extracellular region|extracellular space|nucleus|lipid metabolic process|lipid transport|high-density lipoprotein particle binding|phosphatidylethanolamine binding|phosphatidylcholine transporter activity|phosphatidylinositol transfer activity|vitamin E biosynthetic process|positive regulation of cholesterol efflux|phospholipid transport|sterol transport|diacylglycerol binding|low-density lipoprotein particle binding|flagellated sperm motility|phosphatidylcholine binding|very-low-density lipoprotein particle binding|high-density lipoprotein particle|high-density lipoprotein particle remodeling|ceramide transport|glycolipid transport|phosphatidic acid binding|ceramide binding|intermembrane lipid transfer|phospholipid transfer activity|ceramide transfer activity|phosphatidylcholine transfer activity|cholesterol transfer activity|diacylglyceride transfer activity|sphingomyelin transfer activity|phosphatidylglycerol transfer activity|cerebroside transfer activity|phosphatidylglycerol binding|phosphatidylethanolamine transfer activity|phosphatidic acid transfer activity "hsa03320,hsa04979" PPAR signaling pathway|Cholesterol metabolism PLXDC1 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.026737549 0.00809579 57125 plexin domain containing 1 "GO:0001525,GO:0005515,GO:0005576,GO:0005737,GO:0005886,GO:0005923,GO:0016021,GO:0021510,GO:0030425,GO:0043025,GO:0043235" angiogenesis|protein binding|extracellular region|cytoplasm|plasma membrane|bicellular tight junction|integral component of membrane|spinal cord development|dendrite|neuronal cell body|receptor complex PLXNA1 2561.908785 2913.158871 2210.658699 0.758852777 -0.398108076 0.092283851 1 16.701035 12.4615508 5361 plexin A1 "GO:0002116,GO:0005654,GO:0005829,GO:0005886,GO:0005887,GO:0007162,GO:0007275,GO:0008360,GO:0014910,GO:0017154,GO:0030334,GO:0038023,GO:0043087,GO:0050772,GO:0060666,GO:0070062,GO:1902287,GO:1990138" semaphorin receptor complex|nucleoplasm|cytosol|plasma membrane|integral component of plasma membrane|negative regulation of cell adhesion|multicellular organism development|regulation of cell shape|regulation of smooth muscle cell migration|semaphorin receptor activity|regulation of cell migration|signaling receptor activity|regulation of GTPase activity|positive regulation of axonogenesis|dichotomous subdivision of terminal units involved in salivary gland branching|extracellular exosome|semaphorin-plexin signaling pathway involved in axon guidance|neuron projection extension hsa04360 Axon guidance PLXNA2 950.8651746 890.5942835 1011.136066 1.135349827 0.183136893 0.459731498 1 3.872993813 4.32362162 5362 plexin A2 "GO:0001756,GO:0002116,GO:0005515,GO:0005886,GO:0005887,GO:0007162,GO:0008360,GO:0017154,GO:0021915,GO:0021935,GO:0030334,GO:0042802,GO:0043087,GO:0050772,GO:0051642,GO:0060037,GO:0060174,GO:0071526,GO:1902287" somitogenesis|semaphorin receptor complex|protein binding|plasma membrane|integral component of plasma membrane|negative regulation of cell adhesion|regulation of cell shape|semaphorin receptor activity|neural tube development|cerebellar granule cell precursor tangential migration|regulation of cell migration|identical protein binding|regulation of GTPase activity|positive regulation of axonogenesis|centrosome localization|pharyngeal system development|limb bud formation|semaphorin-plexin signaling pathway|semaphorin-plexin signaling pathway involved in axon guidance hsa04360 Axon guidance PLXNA3 2132.826763 2132.848459 2132.805066 0.999979655 -2.94E-05 1 1 16.85814607 16.57571058 55558 plexin A3 "GO:0002116,GO:0004888,GO:0005515,GO:0005886,GO:0005887,GO:0007162,GO:0007275,GO:0008360,GO:0016020,GO:0017154,GO:0021612,GO:0021637,GO:0021766,GO:0021785,GO:0021860,GO:0030334,GO:0043087,GO:0048843,GO:0050772,GO:0050919,GO:0051495,GO:0071526,GO:1902287,GO:1990138" semaphorin receptor complex|transmembrane signaling receptor activity|protein binding|plasma membrane|integral component of plasma membrane|negative regulation of cell adhesion|multicellular organism development|regulation of cell shape|membrane|semaphorin receptor activity|facial nerve structural organization|trigeminal nerve structural organization|hippocampus development|branchiomotor neuron axon guidance|pyramidal neuron development|regulation of cell migration|regulation of GTPase activity|negative regulation of axon extension involved in axon guidance|positive regulation of axonogenesis|negative chemotaxis|positive regulation of cytoskeleton organization|semaphorin-plexin signaling pathway|semaphorin-plexin signaling pathway involved in axon guidance|neuron projection extension hsa04360 Axon guidance PLXNB1 561.271763 604.4804658 518.0630603 0.857038547 -0.222568001 0.405142338 1 2.873687108 2.421647987 5364 plexin B1 "GO:0002116,GO:0004888,GO:0005096,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0007162,GO:0007165,GO:0007186,GO:0008360,GO:0014068,GO:0016477,GO:0017154,GO:0030215,GO:0030334,GO:0032794,GO:0033689,GO:0035556,GO:0038023,GO:0043087,GO:0043547,GO:0043931,GO:0048812,GO:0050772,GO:0051493,GO:0071526,GO:1900220,GO:1902287,GO:1904862" semaphorin receptor complex|transmembrane signaling receptor activity|GTPase activator activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|negative regulation of cell adhesion|signal transduction|G protein-coupled receptor signaling pathway|regulation of cell shape|positive regulation of phosphatidylinositol 3-kinase signaling|cell migration|semaphorin receptor activity|semaphorin receptor binding|regulation of cell migration|GTPase activating protein binding|negative regulation of osteoblast proliferation|intracellular signal transduction|signaling receptor activity|regulation of GTPase activity|positive regulation of GTPase activity|ossification involved in bone maturation|neuron projection morphogenesis|positive regulation of axonogenesis|regulation of cytoskeleton organization|semaphorin-plexin signaling pathway|semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis|semaphorin-plexin signaling pathway involved in axon guidance|inhibitory synapse assembly hsa04360 Axon guidance PLXNB2 5096.490635 5563.09303 4629.88824 0.832250731 -0.264909863 0.270220739 1 40.03938645 32.76519656 23654 plexin B2 "GO:0001843,GO:0001932,GO:0002116,GO:0005515,GO:0005887,GO:0007156,GO:0007162,GO:0007405,GO:0007420,GO:0008360,GO:0009986,GO:0010976,GO:0017154,GO:0030334,GO:0043087,GO:0045727,GO:0050772,GO:0070062,GO:0071526,GO:1902287,GO:1904861,GO:2001222" neural tube closure|regulation of protein phosphorylation|semaphorin receptor complex|protein binding|integral component of plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|negative regulation of cell adhesion|neuroblast proliferation|brain development|regulation of cell shape|cell surface|positive regulation of neuron projection development|semaphorin receptor activity|regulation of cell migration|regulation of GTPase activity|positive regulation of translation|positive regulation of axonogenesis|extracellular exosome|semaphorin-plexin signaling pathway|semaphorin-plexin signaling pathway involved in axon guidance|excitatory synapse assembly|regulation of neuron migration hsa04360 Axon guidance PLXNB3 1052.43509 970.7061525 1134.164028 1.168390687 0.224522763 0.359594269 1 8.198259737 9.418482574 5365 plexin B3 "GO:0001938,GO:0002116,GO:0005515,GO:0005886,GO:0005887,GO:0007156,GO:0007162,GO:0008360,GO:0009986,GO:0010593,GO:0010976,GO:0017154,GO:0019904,GO:0030334,GO:0030336,GO:0034260,GO:0043087,GO:0050772,GO:0050918,GO:0051022,GO:0060326,GO:0071526,GO:0098632,GO:1902287" positive regulation of endothelial cell proliferation|semaphorin receptor complex|protein binding|plasma membrane|integral component of plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|negative regulation of cell adhesion|regulation of cell shape|cell surface|negative regulation of lamellipodium assembly|positive regulation of neuron projection development|semaphorin receptor activity|protein domain specific binding|regulation of cell migration|negative regulation of cell migration|negative regulation of GTPase activity|regulation of GTPase activity|positive regulation of axonogenesis|positive chemotaxis|Rho GDP-dissociation inhibitor binding|cell chemotaxis|semaphorin-plexin signaling pathway|cell-cell adhesion mediator activity|semaphorin-plexin signaling pathway involved in axon guidance hsa04360 Axon guidance PLXNC1 66.8097854 75.95021343 57.66935736 0.759304744 -0.397249073 0.470911277 1 0.369054293 0.275535495 10154 plexin C1 "GO:0002116,GO:0005102,GO:0005515,GO:0005886,GO:0005887,GO:0007155,GO:0007162,GO:0008360,GO:0016020,GO:0017154,GO:0030334,GO:0043087,GO:0050772,GO:1902287" semaphorin receptor complex|signaling receptor binding|protein binding|plasma membrane|integral component of plasma membrane|cell adhesion|negative regulation of cell adhesion|regulation of cell shape|membrane|semaphorin receptor activity|regulation of cell migration|regulation of GTPase activity|positive regulation of axonogenesis|semaphorin-plexin signaling pathway involved in axon guidance hsa04360 Axon guidance PLXND1 1087.446242 1246.415831 928.4766535 0.74491725 -0.424847924 0.081650912 1 9.625079165 7.049909145 23129 plexin D1 "GO:0001525,GO:0001569,GO:0001822,GO:0002116,GO:0003151,GO:0003279,GO:0005515,GO:0005886,GO:0005887,GO:0007162,GO:0007221,GO:0007416,GO:0008360,GO:0017154,GO:0019904,GO:0030027,GO:0030334,GO:0031258,GO:0032092,GO:0035904,GO:0043087,GO:0043542,GO:0045765,GO:0050772,GO:0060666,GO:0060976,GO:0071526,GO:1902287" angiogenesis|branching involved in blood vessel morphogenesis|kidney development|semaphorin receptor complex|outflow tract morphogenesis|cardiac septum development|protein binding|plasma membrane|integral component of plasma membrane|negative regulation of cell adhesion|positive regulation of transcription of Notch receptor target|synapse assembly|regulation of cell shape|semaphorin receptor activity|protein domain specific binding|lamellipodium|regulation of cell migration|lamellipodium membrane|positive regulation of protein binding|aorta development|regulation of GTPase activity|endothelial cell migration|regulation of angiogenesis|positive regulation of axonogenesis|dichotomous subdivision of terminal units involved in salivary gland branching|coronary vasculature development|semaphorin-plexin signaling pathway|semaphorin-plexin signaling pathway involved in axon guidance PM20D2 596.576638 648.1778489 544.975427 0.840780702 -0.250198538 0.34285597 1 3.975185072 3.28633072 135293 peptidase M20 domain containing 2 "GO:0005515,GO:0005654,GO:0005737,GO:0006508,GO:0016805,GO:0032268,GO:0042802,GO:0046657,GO:0071713" protein binding|nucleoplasm|cytoplasm|proteolysis|dipeptidase activity|regulation of cellular protein metabolic process|identical protein binding|folic acid catabolic process|para-aminobenzoyl-glutamate hydrolase activity PMAIP1 3288.768558 3247.131728 3330.405388 1.025645298 0.036531885 0.878725769 1 90.3982537 91.16505802 5366 phorbol-12-myristate-13-acetate-induced protein 1 "GO:0001836,GO:0001844,GO:0005515,GO:0005634,GO:0005739,GO:0005741,GO:0005829,GO:0006915,GO:0006919,GO:0006974,GO:0010498,GO:0010907,GO:0010917,GO:0042149,GO:0042981,GO:0043029,GO:0043065,GO:0043280,GO:0043331,GO:0043517,GO:0046902,GO:0051607,GO:0071456,GO:0072332,GO:0072593,GO:0090200,GO:0097193,GO:1900740,GO:1902043,GO:1902237,GO:2001244" "release of cytochrome c from mitochondria|protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|protein binding|nucleus|mitochondrion|mitochondrial outer membrane|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to DNA damage stimulus|proteasomal protein catabolic process|positive regulation of glucose metabolic process|negative regulation of mitochondrial membrane potential|cellular response to glucose starvation|regulation of apoptotic process|T cell homeostasis|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|response to dsRNA|positive regulation of DNA damage response, signal transduction by p53 class mediator|regulation of mitochondrial membrane permeability|defense response to virus|cellular response to hypoxia|intrinsic apoptotic signaling pathway by p53 class mediator|reactive oxygen species metabolic process|positive regulation of release of cytochrome c from mitochondria|intrinsic apoptotic signaling pathway|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway" "hsa01524,hsa04115,hsa04210,hsa04215,hsa05200,hsa05203,hsa05210" Platinum drug resistance|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Pathways in cancer|Viral carcinogenesis|Colorectal cancer PMEL 34.5468942 36.41448589 32.6793025 0.897425893 -0.156135286 0.859898515 1 0.900544108 0.794647943 6490 premelanosome protein "GO:0005515,GO:0005576,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005887,GO:0032438,GO:0032585,GO:0042438,GO:0042470,GO:0042802" protein binding|extracellular region|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|melanosome organization|multivesicular body membrane|melanin biosynthetic process|melanosome|identical protein binding PMEPA1 251.4247277 292.356301 210.4931544 0.719988431 -0.473954371 0.156200931 1 2.829618872 2.003201514 56937 "prostate transmembrane protein, androgen induced 1" "GO:0000139,GO:0005515,GO:0005886,GO:0010008,GO:0010991,GO:0016021,GO:0030512,GO:0030521,GO:0031901,GO:0043231,GO:0050699,GO:0060394,GO:0070412" Golgi membrane|protein binding|plasma membrane|endosome membrane|negative regulation of SMAD protein complex assembly|integral component of membrane|negative regulation of transforming growth factor beta receptor signaling pathway|androgen receptor signaling pathway|early endosome membrane|intracellular membrane-bounded organelle|WW domain binding|negative regulation of pathway-restricted SMAD protein phosphorylation|R-SMAD binding PMF1 135.7450579 144.6175297 126.8725862 0.877297424 -0.188862063 0.664650925 1 6.254434168 5.395181484 11243 polyamine modulated factor 1 "GO:0000444,GO:0000777,GO:0000818,GO:0003713,GO:0005515,GO:0005654,GO:0005667,GO:0005794,GO:0005829,GO:0006366,GO:0007049,GO:0007059,GO:0043231,GO:0043522,GO:0045893,GO:0051301" "MIS12/MIND type complex|condensed chromosome kinetochore|nuclear MIS12/MIND complex|transcription coactivator activity|protein binding|nucleoplasm|transcription regulator complex|Golgi apparatus|cytosol|transcription by RNA polymerase II|cell cycle|chromosome segregation|intracellular membrane-bounded organelle|leucine zipper domain binding|positive regulation of transcription, DNA-templated|cell division" PMFBP1 18.89099616 29.13158871 8.650403604 0.296942391 -1.751745031 0.048743589 1 0.316574903 0.09243147 83449 polyamine modulated factor 1 binding protein 1 "GO:0003674,GO:0005737,GO:0007283,GO:0097224" molecular_function|cytoplasm|spermatogenesis|sperm connecting piece PML 1224.1927 1291.153628 1157.231771 0.896277364 -0.157982833 0.514637974 1 9.862100487 8.691265768 5371 PML nuclear body scaffold "GO:0000781,GO:0000785,GO:0000792,GO:0001666,GO:0001932,GO:0003677,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006355,GO:0006606,GO:0006919,GO:0006977,GO:0007050,GO:0007179,GO:0007182,GO:0008270,GO:0008285,GO:0008630,GO:0008631,GO:0009411,GO:0010332,GO:0010522,GO:0010761,GO:0016032,GO:0016363,GO:0016525,GO:0016567,GO:0016605,GO:0030099,GO:0030155,GO:0030308,GO:0030578,GO:0031625,GO:0031901,GO:0032183,GO:0032206,GO:0032469,GO:0032691,GO:0032922,GO:0034097,GO:0042406,GO:0042752,GO:0042771,GO:0042803,GO:0043153,GO:0043161,GO:0045087,GO:0045165,GO:0045892,GO:0045893,GO:0046332,GO:0048146,GO:0048384,GO:0051457,GO:0051607,GO:0060333,GO:0060444,GO:0065003,GO:0070059,GO:0071353,GO:0090398,GO:0097191,GO:0140037,GO:1901796,GO:1902187,GO:1990830,GO:2000059,GO:2000779,GO:2001238" "chromosome, telomeric region|chromatin|heterochromatin|response to hypoxia|regulation of protein phosphorylation|DNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|regulation of transcription, DNA-templated|protein import into nucleus|activation of cysteine-type endopeptidase activity involved in apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|cell cycle arrest|transforming growth factor beta receptor signaling pathway|common-partner SMAD protein phosphorylation|zinc ion binding|negative regulation of cell population proliferation|intrinsic apoptotic signaling pathway in response to DNA damage|intrinsic apoptotic signaling pathway in response to oxidative stress|response to UV|response to gamma radiation|regulation of calcium ion transport into cytosol|fibroblast migration|viral process|nuclear matrix|negative regulation of angiogenesis|protein ubiquitination|PML body|myeloid cell differentiation|regulation of cell adhesion|negative regulation of cell growth|PML body organization|ubiquitin protein ligase binding|early endosome membrane|SUMO binding|positive regulation of telomere maintenance|endoplasmic reticulum calcium ion homeostasis|negative regulation of interleukin-1 beta production|circadian regulation of gene expression|response to cytokine|extrinsic component of endoplasmic reticulum membrane|regulation of circadian rhythm|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|protein homodimerization activity|entrainment of circadian clock by photoperiod|proteasome-mediated ubiquitin-dependent protein catabolic process|innate immune response|cell fate commitment|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|SMAD binding|positive regulation of fibroblast proliferation|retinoic acid receptor signaling pathway|maintenance of protein location in nucleus|defense response to virus|interferon-gamma-mediated signaling pathway|branching involved in mammary gland duct morphogenesis|protein-containing complex assembly|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to interleukin-4|cellular senescence|extrinsic apoptotic signaling pathway|sumo-dependent protein binding|regulation of signal transduction by p53 class mediator|negative regulation of viral release from host cell|cellular response to leukemia inhibitory factor|negative regulation of ubiquitin-dependent protein catabolic process|regulation of double-strand break repair|positive regulation of extrinsic apoptotic signaling pathway" "hsa04120,hsa04144,hsa05164,hsa05168,hsa05200,hsa05202,hsa05221" Ubiquitin mediated proteolysis|Endocytosis|Influenza A|Herpes simplex virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia other PMM1 1350.035547 1163.182721 1536.888374 1.321278546 0.401934641 0.094133745 1 42.28673295 54.9376015 5372 phosphomannomutase 1 "GO:0004615,GO:0005515,GO:0005829,GO:0006013,GO:0006487,GO:0009298,GO:0043025,GO:0046872,GO:1990830" phosphomannomutase activity|protein binding|cytosol|mannose metabolic process|protein N-linked glycosylation|GDP-mannose biosynthetic process|neuronal cell body|metal ion binding|cellular response to leukemia inhibitory factor "hsa00051,hsa00520" Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism PMM2 725.3759521 736.6130289 714.1388753 0.969489878 -0.044702259 0.865955811 1 17.01068088 16.21571695 5373 phosphomannomutase 2 "GO:0004615,GO:0005515,GO:0005654,GO:0005829,GO:0006013,GO:0006486,GO:0006487,GO:0009298,GO:0043025,GO:0046872" phosphomannomutase activity|protein binding|nucleoplasm|cytosol|mannose metabolic process|protein glycosylation|protein N-linked glycosylation|GDP-mannose biosynthetic process|neuronal cell body|metal ion binding "hsa00051,hsa00520" Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism PMP22 563.8086311 570.1468077 557.4704545 0.97776651 -0.032438103 0.909851464 1 14.4755886 13.91690198 5376 peripheral myelin protein 22 "GO:0005515,GO:0005886,GO:0007268,GO:0007422,GO:0008219,GO:0016021,GO:0032060,GO:0032288,GO:0045202" protein binding|plasma membrane|chemical synaptic transmission|peripheral nervous system development|cell death|integral component of membrane|bleb assembly|myelin assembly|synapse PMPCA 1114.513323 1061.22216 1167.804487 1.100433566 0.138072052 0.572529867 1 17.57773937 19.01945326 23203 "peptidase, mitochondrial processing subunit alpha" "GO:0005515,GO:0005615,GO:0005739,GO:0005743,GO:0005759,GO:0006627,GO:0006851,GO:0046872" protein binding|extracellular space|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|protein processing involved in protein targeting to mitochondrion|mitochondrial calcium ion transmembrane transport|metal ion binding PMPCB 1630.111286 1513.802199 1746.420372 1.15366484 0.206224157 0.386311669 1 18.16295889 20.6033308 9512 "peptidase, mitochondrial processing subunit beta" "GO:0004222,GO:0005739,GO:0005743,GO:0006627,GO:0006851,GO:0017087,GO:0046872" metalloendopeptidase activity|mitochondrion|mitochondrial inner membrane|protein processing involved in protein targeting to mitochondrion|mitochondrial calcium ion transmembrane transport|mitochondrial processing peptidase complex|metal ion binding PMS1 701.1545532 618.0058463 784.3032601 1.269087121 0.343791111 0.17970811 1 6.515574115 8.130463502 5378 "PMS1 homolog 1, mismatch repair system component" "GO:0003677,GO:0005515,GO:0005524,GO:0005634,GO:0006298,GO:0016887,GO:0019899,GO:0030983,GO:0032300,GO:0042493" DNA binding|protein binding|ATP binding|nucleus|mismatch repair|ATPase activity|enzyme binding|mismatched DNA binding|mismatch repair complex|response to drug PMS2 476.2000145 528.5302524 423.8697766 0.801978268 -0.318364951 0.249924688 1 5.291068875 4.172316003 5395 "PMS1 homolog 2, mismatch repair system component" "GO:0003677,GO:0003697,GO:0004519,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006298,GO:0016446,GO:0016887,GO:0032138,GO:0032300,GO:0032389,GO:0032407,GO:0036464,GO:0042493,GO:0090305" DNA binding|single-stranded DNA binding|endonuclease activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|mismatch repair|somatic hypermutation of immunoglobulin genes|ATPase activity|single base insertion or deletion binding|mismatch repair complex|MutLalpha complex|MutSalpha complex binding|cytoplasmic ribonucleoprotein granule|response to drug|nucleic acid phosphodiester bond hydrolysis "hsa03430,hsa03460" Mismatch repair|Fanconi anemia pathway PMVK 388.027146 396.3976893 379.6566026 0.957766942 -0.062253454 0.839107954 1 16.51445443 15.55232247 10654 phosphomevalonate kinase "GO:0004631,GO:0005515,GO:0005524,GO:0005777,GO:0005829,GO:0006695,GO:0016020,GO:0016126,GO:0016310,GO:0019287,GO:0045540,GO:0070062,GO:0070723" "phosphomevalonate kinase activity|protein binding|ATP binding|peroxisome|cytosol|cholesterol biosynthetic process|membrane|sterol biosynthetic process|phosphorylation|isopentenyl diphosphate biosynthetic process, mevalonate pathway|regulation of cholesterol biosynthetic process|extracellular exosome|response to cholesterol" "hsa00900,hsa04146" Terpenoid backbone biosynthesis|Peroxisome PNCK 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.05349227 0.01619678 139728 pregnancy up-regulated nonubiquitous CaM kinase "GO:0004683,GO:0005516,GO:0005524,GO:0005622,GO:0005634,GO:0005737,GO:0018105" calmodulin-dependent protein kinase activity|calmodulin binding|ATP binding|intracellular anatomical structure|nucleus|cytoplasm|peptidyl-serine phosphorylation PNISR 1685.475904 1667.783454 1703.168354 1.021216723 0.030289068 0.901028842 1 11.16209402 11.20817164 25957 PNN interacting serine and arginine rich protein "GO:0003723,GO:0005654,GO:0005829,GO:0005886,GO:0016607,GO:0048786" RNA binding|nucleoplasm|cytosol|plasma membrane|nuclear speck|presynaptic active zone PNKD 806.4942508 784.4720675 828.5164341 1.056145232 0.078808236 0.75780734 1 11.38586686 11.82390475 25953 PNKD metallo-beta-lactamase domain containing "GO:0004416,GO:0005515,GO:0005634,GO:0005739,GO:0016020,GO:0019243,GO:0032225,GO:0042053,GO:0046872,GO:0046929,GO:0050884" "hydroxyacylglutathione hydrolase activity|protein binding|nucleus|mitochondrion|membrane|methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione|regulation of synaptic transmission, dopaminergic|regulation of dopamine metabolic process|metal ion binding|negative regulation of neurotransmitter secretion|neuromuscular process controlling posture" PNKP 363.7063674 325.6495453 401.7631896 1.233728698 0.303025175 0.309028937 1 10.04004489 12.17941701 11284 polynucleotide kinase 3'-phosphatase "GO:0000718,GO:0003684,GO:0003690,GO:0004519,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005739,GO:0006261,GO:0006281,GO:0006979,GO:0009314,GO:0010836,GO:0016020,GO:0016311,GO:0017076,GO:0032212,GO:0042769,GO:0046403,GO:0046404,GO:0046939,GO:0051973,GO:0090305,GO:0098506,GO:1904355,GO:2001034" "nucleotide-excision repair, DNA damage removal|damaged DNA binding|double-stranded DNA binding|endonuclease activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|mitochondrion|DNA-dependent DNA replication|DNA repair|response to oxidative stress|response to radiation|negative regulation of protein ADP-ribosylation|membrane|dephosphorylation|purine nucleotide binding|positive regulation of telomere maintenance via telomerase|DNA damage response, detection of DNA damage|polynucleotide 3'-phosphatase activity|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|nucleotide phosphorylation|positive regulation of telomerase activity|nucleic acid phosphodiester bond hydrolysis|polynucleotide 3' dephosphorylation|positive regulation of telomere capping|positive regulation of double-strand break repair via nonhomologous end joining" PNLIPRP3 8.085537281 10.40413883 5.766935736 0.554292463 -0.851280704 0.546153423 1 0.217403981 0.118488894 119548 pancreatic lipase related protein 3 "GO:0004806,GO:0005615,GO:0016042,GO:0016298" triglyceride lipase activity|extracellular space|lipid catabolic process|lipase activity hsa00561 Glycerolipid metabolism PNMA1 905.0863494 899.9580085 910.2146903 1.011396845 0.016349183 0.952324573 1 18.45853377 18.35650401 9240 PNMA family member 1 "GO:0002437,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0043065" inflammatory response to antigenic stimulus|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|positive regulation of apoptotic process PNMT 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.086018554 0.117203964 5409 phenylethanolamine N-methyltransferase "GO:0004603,GO:0005515,GO:0005829,GO:0008170,GO:0032259,GO:0042418,GO:0042423" phenylethanolamine N-methyltransferase activity|protein binding|cytosol|N-methyltransferase activity|methylation|epinephrine biosynthetic process|catecholamine biosynthetic process hsa00350 Tyrosine metabolism PNN 1910.607237 2014.241277 1806.973197 0.897098683 -0.156661401 0.508911514 1 30.39195785 26.80834946 5411 "pinin, desmosome associated protein" "GO:0000398,GO:0003677,GO:0003723,GO:0005198,GO:0005515,GO:0005882,GO:0005886,GO:0005911,GO:0007155,GO:0016020,GO:0016607,GO:0030057,GO:0035145,GO:0071013" "mRNA splicing, via spliceosome|DNA binding|RNA binding|structural molecule activity|protein binding|intermediate filament|plasma membrane|cell-cell junction|cell adhesion|membrane|nuclear speck|desmosome|exon-exon junction complex|catalytic step 2 spliceosome" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway PNO1 376.5329034 397.4381032 355.6277037 0.894800224 -0.160362477 0.590313312 1 6.672079618 5.870275487 56902 partner of NOB1 homolog "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005829" RNA binding|protein binding|nucleoplasm|nucleolus|cytosol PNP 1235.196918 1214.163001 1256.230834 1.0346476 0.04913947 0.841871871 1 43.87112243 44.63159206 4860 purine nucleoside phosphorylase "GO:0001882,GO:0002060,GO:0004731,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0006139,GO:0006148,GO:0006195,GO:0006738,GO:0006955,GO:0009165,GO:0032623,GO:0034418,GO:0034774,GO:0042102,GO:0042301,GO:0042493,GO:0042802,GO:0043101,GO:0043312,GO:0046638,GO:0070062,GO:1904813" nucleoside binding|purine nucleobase binding|purine-nucleoside phosphorylase activity|protein binding|extracellular region|nucleus|cytoplasm|cytosol|cytoskeleton|nucleobase-containing compound metabolic process|inosine catabolic process|purine nucleotide catabolic process|nicotinamide riboside catabolic process|immune response|nucleotide biosynthetic process|interleukin-2 production|urate biosynthetic process|secretory granule lumen|positive regulation of T cell proliferation|phosphate ion binding|response to drug|identical protein binding|purine-containing compound salvage|neutrophil degranulation|positive regulation of alpha-beta T cell differentiation|extracellular exosome|ficolin-1-rich granule lumen "hsa00230,hsa00240,hsa00760" Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism PNPLA2 1875.169613 1803.037259 1947.301967 1.080012051 0.11104741 0.640440911 1 45.97457461 48.8222173 57104 patatin like phospholipase domain containing 2 "GO:0004806,GO:0005654,GO:0005737,GO:0005788,GO:0005789,GO:0005811,GO:0005829,GO:0005886,GO:0006651,GO:0010891,GO:0010898,GO:0016020,GO:0016021,GO:0019433,GO:0019915,GO:0034389,GO:0036155,GO:0042572,GO:0043687,GO:0044267,GO:0050253,GO:0055088" triglyceride lipase activity|nucleoplasm|cytoplasm|endoplasmic reticulum lumen|endoplasmic reticulum membrane|lipid droplet|cytosol|plasma membrane|diacylglycerol biosynthetic process|negative regulation of sequestering of triglyceride|positive regulation of triglyceride catabolic process|membrane|integral component of membrane|triglyceride catabolic process|lipid storage|lipid droplet organization|acylglycerol acyl-chain remodeling|retinol metabolic process|post-translational protein modification|cellular protein metabolic process|retinyl-palmitate esterase activity|lipid homeostasis "hsa00561,hsa04714,hsa04923" Glycerolipid metabolism|Thermogenesis|Regulation of lipolysis in adipocytes PNPLA3 27.21933764 33.29324424 21.14543103 0.635126781 -0.654883491 0.396131781 1 0.645404742 0.403054483 80339 patatin like phospholipase domain containing 3 "GO:0001676,GO:0003841,GO:0004623,GO:0004806,GO:0005737,GO:0005789,GO:0005811,GO:0006650,GO:0006654,GO:0009744,GO:0016020,GO:0016021,GO:0019432,GO:0019433,GO:0032869,GO:0034389,GO:0035727,GO:0036042,GO:0036153,GO:0036155,GO:0042171,GO:0050872,GO:0051264,GO:0051265,GO:0055088,GO:1905243" "long-chain fatty acid metabolic process|1-acylglycerol-3-phosphate O-acyltransferase activity|phospholipase A2 activity|triglyceride lipase activity|cytoplasm|endoplasmic reticulum membrane|lipid droplet|glycerophospholipid metabolic process|phosphatidic acid biosynthetic process|response to sucrose|membrane|integral component of membrane|triglyceride biosynthetic process|triglyceride catabolic process|cellular response to insulin stimulus|lipid droplet organization|lysophosphatidic acid binding|long-chain fatty acyl-CoA binding|triglyceride acyl-chain remodeling|acylglycerol acyl-chain remodeling|lysophosphatidic acid acyltransferase activity|white fat cell differentiation|mono-olein transacylation activity|diolein transacylation activity|lipid homeostasis|cellular response to 3,3',5-triiodo-L-thyronine" hsa00561 Glycerolipid metabolism PNPLA4 444.398194 438.0142446 450.7821434 1.029149506 0.04145258 0.8908805 1 5.488615919 5.554084583 8228 patatin like phospholipase domain containing 4 "GO:0004806,GO:0005737,GO:0005739,GO:0005811,GO:0005829,GO:0008150,GO:0016020,GO:0019433,GO:0042572,GO:0050253,GO:0055088" triglyceride lipase activity|cytoplasm|mitochondrion|lipid droplet|cytosol|biological_process|membrane|triglyceride catabolic process|retinol metabolic process|retinyl-palmitate esterase activity|lipid homeostasis hsa00830 Retinol metabolism PNPLA6 1238.145167 1152.778582 1323.511751 1.148105779 0.199255568 0.410171595 1 12.39107235 13.98820454 10908 patatin like phospholipase domain containing 6 "GO:0004622,GO:0005783,GO:0005789,GO:0005829,GO:0016020,GO:0016021,GO:0046470,GO:0046475,GO:0102545" lysophospholipase activity|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|membrane|integral component of membrane|phosphatidylcholine metabolic process|glycerophospholipid catabolic process|phosphatidyl phospholipase B activity hsa00564 Glycerophospholipid metabolism PNPLA7 25.74300516 19.76786377 31.71814655 1.604530814 0.682151496 0.388925605 1 0.210826251 0.332616604 375775 patatin like phospholipase domain containing 7 "GO:0004622,GO:0005783,GO:0005789,GO:0005811,GO:0016021,GO:0034638,GO:0102545" lysophospholipase activity|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|integral component of membrane|phosphatidylcholine catabolic process|phosphatidyl phospholipase B activity hsa00564 Glycerophospholipid metabolism PNPLA8 1081.12573 1030.009744 1132.241716 1.099253403 0.136523999 0.577905003 1 9.920542673 10.7227067 50640 patatin like phospholipase domain containing 8 "GO:0001516,GO:0004620,GO:0004622,GO:0005524,GO:0005739,GO:0005777,GO:0005778,GO:0005789,GO:0006631,GO:0008219,GO:0016020,GO:0016021,GO:0019369,GO:0031966,GO:0034638,GO:0036151,GO:0036152,GO:0043651,GO:0046338,GO:0047499,GO:0050482,GO:0055088,GO:0070328,GO:0102545" prostaglandin biosynthetic process|phospholipase activity|lysophospholipase activity|ATP binding|mitochondrion|peroxisome|peroxisomal membrane|endoplasmic reticulum membrane|fatty acid metabolic process|cell death|membrane|integral component of membrane|arachidonic acid metabolic process|mitochondrial membrane|phosphatidylcholine catabolic process|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|linoleic acid metabolic process|phosphatidylethanolamine catabolic process|calcium-independent phospholipase A2 activity|arachidonic acid secretion|lipid homeostasis|triglyceride homeostasis|phosphatidyl phospholipase B activity PNPO 636.8263012 645.0566072 628.5959952 0.974481911 -0.03729269 0.892034665 1 9.9380732 9.522416029 55163 pyridoxamine 5'-phosphate oxidase "GO:0004733,GO:0005515,GO:0005829,GO:0008615,GO:0010181,GO:0030170,GO:0042803,GO:0042816,GO:0042823,GO:0055114" pyridoxamine-phosphate oxidase activity|protein binding|cytosol|pyridoxine biosynthetic process|FMN binding|pyridoxal phosphate binding|protein homodimerization activity|vitamin B6 metabolic process|pyridoxal phosphate biosynthetic process|oxidation-reduction process hsa00750 Vitamin B6 metabolism PNPT1 639.6946778 682.511507 596.8778487 0.874531554 -0.193417656 0.458681438 1 8.014166056 6.891360976 87178 polyribonucleotide nucleotidyltransferase 1 "GO:0000175,GO:0000957,GO:0000958,GO:0000962,GO:0000964,GO:0000965,GO:0003723,GO:0004654,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005758,GO:0005759,GO:0005789,GO:0005829,GO:0006401,GO:0006402,GO:0008266,GO:0034046,GO:0034599,GO:0035198,GO:0035458,GO:0035927,GO:0035928,GO:0042788,GO:0043457,GO:0043631,GO:0045025,GO:0045926,GO:0051260,GO:0051591,GO:0060416,GO:0061014,GO:0070207,GO:0070584,GO:0071042,GO:0071850,GO:0090503,GO:0097222,GO:0097421,GO:2000627,GO:2000772" "3'-5'-exoribonuclease activity|mitochondrial RNA catabolic process|mitochondrial mRNA catabolic process|positive regulation of mitochondrial RNA catabolic process|mitochondrial RNA 5'-end processing|mitochondrial RNA 3'-end processing|RNA binding|polyribonucleotide nucleotidyltransferase activity|protein binding|nucleus|cytoplasm|mitochondrion|mitochondrial intermembrane space|mitochondrial matrix|endoplasmic reticulum membrane|cytosol|RNA catabolic process|mRNA catabolic process|poly(U) RNA binding|poly(G) binding|cellular response to oxidative stress|miRNA binding|cellular response to interferon-beta|RNA import into mitochondrion|rRNA import into mitochondrion|polysomal ribosome|regulation of cellular respiration|RNA polyadenylation|mitochondrial degradosome|negative regulation of growth|protein homooligomerization|response to cAMP|response to growth hormone|positive regulation of mRNA catabolic process|protein homotrimerization|mitochondrion morphogenesis|nuclear polyadenylation-dependent mRNA catabolic process|mitotic cell cycle arrest|RNA phosphodiester bond hydrolysis, exonucleolytic|mitochondrial mRNA polyadenylation|liver regeneration|positive regulation of miRNA catabolic process|regulation of cellular senescence" hsa03018 RNA degradation PNRC1 790.8182311 827.1290367 754.5074255 0.912200385 -0.132577316 0.601429946 1 21.10055282 18.92584431 10957 proline rich nuclear receptor coactivator 1 "GO:0005515,GO:0005634" protein binding|nucleus PNRC2 2009.537103 1987.190516 2031.883691 1.022490634 0.032087629 0.894189683 1 42.54019476 42.76908816 55629 proline rich nuclear receptor coactivator 2 "GO:0000184,GO:0000932,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0031087" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|P-body|protein binding|nucleus|nucleoplasm|Golgi apparatus|cytosol|deadenylation-independent decapping of nuclear-transcribed mRNA" POC1A 860.8586986 836.4927616 885.2246355 1.058257377 0.081690545 0.746953137 1 14.68972731 15.28537919 25886 POC1 centriolar protein A "GO:0000922,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0030030,GO:0036064" spindle pole|protein binding|cytoplasm|centrosome|centriole|cell projection organization|ciliary basal body POC1B 847.8088656 821.9269673 873.690764 1.062978584 0.088112531 0.727926803 1 13.49684049 14.10677725 282809 POC1 centriolar protein B "GO:0000922,GO:0001895,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0007099,GO:0008283,GO:0036064,GO:0060271" spindle pole|retina homeostasis|protein binding|cytoplasm|centrosome|centriole|centriole replication|cell population proliferation|ciliary basal body|cilium assembly POC5 516.7126036 469.2266611 564.1985462 1.202400871 0.26591796 0.328142103 1 9.288488316 10.98159695 134359 POC5 centriolar protein "GO:0005515,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0007049" protein binding|nucleoplasm|centrosome|centriole|cytosol|cell cycle PODNL1 10.8104893 6.242483296 15.3784953 2.463522058 1.300722389 0.255870018 1 0.096174902 0.232964307 79883 podocan like 1 GO:0005615 extracellular space PODXL 6117.827665 5591.184205 6644.471124 1.188383512 0.249000494 0.304455852 1 49.84818324 58.24747867 5420 podocalyxin like "GO:0001726,GO:0005515,GO:0005615,GO:0005730,GO:0005737,GO:0005886,GO:0005887,GO:0007155,GO:0007162,GO:0016324,GO:0016477,GO:0022408,GO:0030027,GO:0030175,GO:0030335,GO:0031528,GO:0032534,GO:0033634,GO:0034451,GO:0036057,GO:0043231,GO:0045121,GO:0070062,GO:0072015,GO:0072175" ruffle|protein binding|extracellular space|nucleolus|cytoplasm|plasma membrane|integral component of plasma membrane|cell adhesion|negative regulation of cell adhesion|apical plasma membrane|cell migration|negative regulation of cell-cell adhesion|lamellipodium|filopodium|positive regulation of cell migration|microvillus membrane|regulation of microvillus assembly|positive regulation of cell-cell adhesion mediated by integrin|centriolar satellite|slit diaphragm|intracellular membrane-bounded organelle|membrane raft|extracellular exosome|glomerular visceral epithelial cell development|epithelial tube formation hsa05132 Salmonella infection POF1B 108.4364015 134.2133909 82.65941222 0.615880514 -0.699277611 0.124012678 1 1.812888382 1.097839135 79983 POF1B actin binding protein "GO:0003382,GO:0005884,GO:0005912,GO:0005923,GO:0007015,GO:0030036,GO:0030057,GO:0051015,GO:0070830" epithelial cell morphogenesis|actin filament|adherens junction|bicellular tight junction|actin filament organization|actin cytoskeleton organization|desmosome|actin filament binding|bicellular tight junction assembly POFUT1 2806.899144 2973.502877 2640.295411 0.887941099 -0.171464116 0.468874166 1 25.83692339 22.55776843 23509 protein O-fucosyltransferase 1 "GO:0001525,GO:0001756,GO:0005783,GO:0006004,GO:0006355,GO:0006493,GO:0007219,GO:0007399,GO:0007507,GO:0008417,GO:0008593,GO:0016020,GO:0016266,GO:0036066,GO:0046922" "angiogenesis|somitogenesis|endoplasmic reticulum|fucose metabolic process|regulation of transcription, DNA-templated|protein O-linked glycosylation|Notch signaling pathway|nervous system development|heart development|fucosyltransferase activity|regulation of Notch signaling pathway|membrane|O-glycan processing|protein O-linked fucosylation|peptide-O-fucosyltransferase activity" hsa00514 Other types of O-glycan biosynthesis POFUT2 1000.533283 869.7860059 1131.28056 1.300642402 0.379224363 0.122939756 1 8.401607337 10.74463006 23275 protein O-fucosyltransferase 2 "GO:0001707,GO:0005789,GO:0005794,GO:0006004,GO:0010468,GO:0010717,GO:0036066,GO:0046922,GO:0051046,GO:1903334" mesoderm formation|endoplasmic reticulum membrane|Golgi apparatus|fucose metabolic process|regulation of gene expression|regulation of epithelial to mesenchymal transition|protein O-linked fucosylation|peptide-O-fucosyltransferase activity|regulation of secretion|positive regulation of protein folding hsa00514 Other types of O-glycan biosynthesis POGK 1514.118386 1547.095443 1481.141328 0.957369071 -0.062852895 0.794427908 1 12.33243322 11.60912117 57645 pogo transposable element derived with KRAB domain "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0007275" "DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|multicellular organism development" POGLUT1 245.137585 291.3158871 198.9592829 0.682967499 -0.550111169 0.102587594 1 3.914147402 2.628502487 56983 protein O-glucosyltransferase 1 "GO:0001756,GO:0005783,GO:0005788,GO:0006493,GO:0007369,GO:0010470,GO:0012505,GO:0018242,GO:0035251,GO:0035252,GO:0045747,GO:0046527,GO:0048318,GO:0048339,GO:0060537,GO:0072359,GO:0140561,GO:0140562" somitogenesis|endoplasmic reticulum|endoplasmic reticulum lumen|protein O-linked glycosylation|gastrulation|regulation of gastrulation|endomembrane system|protein O-linked glycosylation via serine|UDP-glucosyltransferase activity|UDP-xylosyltransferase activity|positive regulation of Notch signaling pathway|glucosyltransferase activity|axial mesoderm development|paraxial mesoderm development|muscle tissue development|circulatory system development|EGF-domain serine glucosyltransferase activity|EGF-domain serine xylosyltransferase activity hsa00514 Other types of O-glycan biosynthesis POGLUT2 626.3032755 621.1270879 631.4794631 1.01666708 0.023847329 0.933689295 1 15.2616994 15.256427 79070 protein O-glucosyltransferase 2 "GO:0005654,GO:0005788,GO:0005829,GO:0012505,GO:0018242,GO:0035251,GO:0035252,GO:0046527" nucleoplasm|endoplasmic reticulum lumen|cytosol|endomembrane system|protein O-linked glycosylation via serine|UDP-glucosyltransferase activity|UDP-xylosyltransferase activity|glucosyltransferase activity POGLUT3 3365.370383 2974.54329 3756.197476 1.262781244 0.336604737 0.155938005 1 35.32396716 43.86001477 143888 protein O-glucosyltransferase 3 "GO:0005575,GO:0005788,GO:0012505,GO:0018242,GO:0035251,GO:0035252,GO:0046527" cellular_component|endoplasmic reticulum lumen|endomembrane system|protein O-linked glycosylation via serine|UDP-glucosyltransferase activity|UDP-xylosyltransferase activity|glucosyltransferase activity POGZ 2000.296067 2160.939634 1839.6525 0.851320634 -0.232225496 0.326537882 1 14.99094978 12.54854833 23126 pogo transposable element derived with ZNF domain "GO:0000785,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007064,GO:0010468,GO:0045944,GO:0046872,GO:0051301,GO:0051382" chromatin|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|mitotic sister chromatid cohesion|regulation of gene expression|positive regulation of transcription by RNA polymerase II|metal ion binding|cell division|kinetochore assembly POLA1 1188.665142 1203.758862 1173.571422 0.974922353 -0.036640774 0.883180975 1 6.935377098 6.64831038 5422 "DNA polymerase alpha 1, catalytic subunit" "GO:0000082,GO:0000083,GO:0000166,GO:0000731,GO:0000785,GO:0003677,GO:0003682,GO:0003688,GO:0003697,GO:0003887,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005658,GO:0005730,GO:0005829,GO:0006260,GO:0006269,GO:0006270,GO:0006271,GO:0006272,GO:0006273,GO:0006281,GO:0006289,GO:0006303,GO:0016032,GO:0016363,GO:0017076,GO:0019103,GO:0019901,GO:0032201,GO:0032479,GO:0046872,GO:0051539,GO:1902975,GO:1904161" "G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|nucleotide binding|DNA synthesis involved in DNA repair|chromatin|DNA binding|chromatin binding|DNA replication origin binding|single-stranded DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleus|nuclear envelope|nucleoplasm|alpha DNA polymerase:primase complex|nucleolus|cytosol|DNA replication|DNA replication, synthesis of RNA primer|DNA replication initiation|DNA strand elongation involved in DNA replication|leading strand elongation|lagging strand elongation|DNA repair|nucleotide-excision repair|double-strand break repair via nonhomologous end joining|viral process|nuclear matrix|purine nucleotide binding|pyrimidine nucleotide binding|protein kinase binding|telomere maintenance via semi-conservative replication|regulation of type I interferon production|metal ion binding|4 iron, 4 sulfur cluster binding|mitotic DNA replication initiation|DNA synthesis involved in UV-damage excision repair" hsa03030 DNA replication POLA2 1797.31095 1815.522225 1779.099675 0.979938251 -0.029237251 0.904196825 1 18.5757447 17.89847884 23649 "DNA polymerase alpha 2, accessory subunit" "GO:0000082,GO:0003674,GO:0003677,GO:0005515,GO:0005654,GO:0005658,GO:0005829,GO:0006260,GO:0006269,GO:0006270,GO:0032201" "G1/S transition of mitotic cell cycle|molecular_function|DNA binding|protein binding|nucleoplasm|alpha DNA polymerase:primase complex|cytosol|DNA replication|DNA replication, synthesis of RNA primer|DNA replication initiation|telomere maintenance via semi-conservative replication" hsa03030 DNA replication POLB 378.8716267 357.9023756 399.8408777 1.117178608 0.159859854 0.590992928 1 13.27351771 14.58074865 5423 DNA polymerase beta "GO:0001701,GO:0003684,GO:0003887,GO:0003906,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005874,GO:0005876,GO:0006261,GO:0006281,GO:0006284,GO:0006286,GO:0006287,GO:0006288,GO:0006290,GO:0006297,GO:0006303,GO:0006954,GO:0006974,GO:0007435,GO:0007568,GO:0008017,GO:0008630,GO:0010332,GO:0016446,GO:0016579,GO:0016829,GO:0019899,GO:0032991,GO:0045471,GO:0046872,GO:0048535,GO:0048536,GO:0048872,GO:0051402,GO:0055093,GO:0071707,GO:0071897" "in utero embryonic development|damaged DNA binding|DNA-directed DNA polymerase activity|DNA-(apurinic or apyrimidinic site) endonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|microtubule|spindle microtubule|DNA-dependent DNA replication|DNA repair|base-excision repair|base-excision repair, base-free sugar-phosphate removal|base-excision repair, gap-filling|base-excision repair, DNA ligation|pyrimidine dimer repair|nucleotide-excision repair, DNA gap filling|double-strand break repair via nonhomologous end joining|inflammatory response|cellular response to DNA damage stimulus|salivary gland morphogenesis|aging|microtubule binding|intrinsic apoptotic signaling pathway in response to DNA damage|response to gamma radiation|somatic hypermutation of immunoglobulin genes|protein deubiquitination|lyase activity|enzyme binding|protein-containing complex|response to ethanol|metal ion binding|lymph node development|spleen development|homeostasis of number of cells|neuron apoptotic process|response to hyperoxia|immunoglobulin heavy chain V-D-J recombination|DNA biosynthetic process" "hsa03410,hsa05166,hsa05203" Base excision repair|Human T-cell leukemia virus 1 infection|Viral carcinogenesis POLD1 1068.30361 1046.656366 1089.950854 1.041364568 0.058475225 0.814252707 1 14.51614516 14.86364341 5424 "DNA polymerase delta 1, catalytic subunit" "GO:0000109,GO:0000166,GO:0000723,GO:0000731,GO:0000781,GO:0003677,GO:0003682,GO:0003684,GO:0003887,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006260,GO:0006261,GO:0006281,GO:0006283,GO:0006287,GO:0006296,GO:0006297,GO:0006298,GO:0008296,GO:0009411,GO:0016020,GO:0016235,GO:0019985,GO:0032201,GO:0033683,GO:0034644,GO:0042769,GO:0043625,GO:0045004,GO:0046872,GO:0051539,GO:0055089,GO:0070987,GO:0071897" "nucleotide-excision repair complex|nucleotide binding|telomere maintenance|DNA synthesis involved in DNA repair|chromosome, telomeric region|DNA binding|chromatin binding|damaged DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleus|nucleoplasm|cytosol|DNA replication|DNA-dependent DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|base-excision repair, gap-filling|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|mismatch repair|3'-5'-exodeoxyribonuclease activity|response to UV|membrane|aggresome|translesion synthesis|telomere maintenance via semi-conservative replication|nucleotide-excision repair, DNA incision|cellular response to UV|DNA damage response, detection of DNA damage|delta DNA polymerase complex|DNA replication proofreading|metal ion binding|4 iron, 4 sulfur cluster binding|fatty acid homeostasis|error-free translesion synthesis|DNA biosynthetic process" "hsa03030,hsa03410,hsa03420,hsa03430,hsa03440" DNA replication|Base excision repair|Nucleotide excision repair|Mismatch repair|Homologous recombination POLD2 3070.459051 2966.219979 3174.698123 1.070284114 0.09799382 0.6797825 1 71.66215872 75.41541834 5425 "DNA polymerase delta 2, accessory subunit" "GO:0000723,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006260,GO:0006271,GO:0006283,GO:0006296,GO:0006297,GO:0006298,GO:0016035,GO:0019985,GO:0032201,GO:0033683,GO:0042575,GO:0042769,GO:0043625,GO:0071897" "telomere maintenance|DNA binding|protein binding|nucleus|nucleoplasm|DNA replication|DNA strand elongation involved in DNA replication|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|mismatch repair|zeta DNA polymerase complex|translesion synthesis|telomere maintenance via semi-conservative replication|nucleotide-excision repair, DNA incision|DNA polymerase complex|DNA damage response, detection of DNA damage|delta DNA polymerase complex|DNA biosynthetic process" "hsa03030,hsa03410,hsa03420,hsa03430,hsa03440" DNA replication|Base excision repair|Nucleotide excision repair|Mismatch repair|Homologous recombination POLD3 1406.553821 1435.771158 1377.336485 0.959300845 -0.059944767 0.804809031 1 18.39281514 17.34899059 10714 "DNA polymerase delta 3, accessory subunit" "GO:0000723,GO:0000731,GO:0003887,GO:0005515,GO:0005654,GO:0005737,GO:0006271,GO:0006283,GO:0006296,GO:0006297,GO:0006298,GO:0016035,GO:0019985,GO:0030674,GO:0032201,GO:0033683,GO:0042769,GO:0043625,GO:0071897,GO:1904161" "telomere maintenance|DNA synthesis involved in DNA repair|DNA-directed DNA polymerase activity|protein binding|nucleoplasm|cytoplasm|DNA strand elongation involved in DNA replication|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|mismatch repair|zeta DNA polymerase complex|translesion synthesis|protein-macromolecule adaptor activity|telomere maintenance via semi-conservative replication|nucleotide-excision repair, DNA incision|DNA damage response, detection of DNA damage|delta DNA polymerase complex|DNA biosynthetic process|DNA synthesis involved in UV-damage excision repair" "hsa03030,hsa03410,hsa03420,hsa03430,hsa03440" DNA replication|Base excision repair|Nucleotide excision repair|Mismatch repair|Homologous recombination POLD4 1161.451449 1057.060505 1265.842394 1.197511768 0.260039834 0.284397313 1 33.30187506 39.21205974 57804 "DNA polymerase delta 4, accessory subunit" "GO:0000723,GO:0000731,GO:0003887,GO:0005515,GO:0005654,GO:0006261,GO:0006283,GO:0006296,GO:0006297,GO:0006298,GO:0019985,GO:0032201,GO:0033683,GO:0042769,GO:0043625" "telomere maintenance|DNA synthesis involved in DNA repair|DNA-directed DNA polymerase activity|protein binding|nucleoplasm|DNA-dependent DNA replication|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|mismatch repair|translesion synthesis|telomere maintenance via semi-conservative replication|nucleotide-excision repair, DNA incision|DNA damage response, detection of DNA damage|delta DNA polymerase complex" "hsa03030,hsa03410,hsa03420,hsa03430,hsa03440" DNA replication|Base excision repair|Nucleotide excision repair|Mismatch repair|Homologous recombination POLDIP2 1781.387096 1876.906644 1685.867547 0.898215983 -0.154865701 0.514515005 1 37.51575206 33.13337031 26073 DNA polymerase delta interacting protein 2 "GO:0003677,GO:0005515,GO:0005634,GO:0005739,GO:0005759,GO:0016242,GO:0042645,GO:0045931,GO:0070584,GO:0070987" DNA binding|protein binding|nucleus|mitochondrion|mitochondrial matrix|negative regulation of macroautophagy|mitochondrial nucleoid|positive regulation of mitotic cell cycle|mitochondrion morphogenesis|error-free translesion synthesis POLDIP3 2078.322692 2228.566537 1928.078848 0.865165485 -0.208951984 0.377233839 1 34.35427502 29.22477336 84271 DNA polymerase delta interacting protein 3 "GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006405,GO:0006406,GO:0016607,GO:0016973,GO:0031124,GO:0036464,GO:0044877,GO:0045727" RNA binding|protein binding|nucleoplasm|cytoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|nuclear speck|poly(A)+ mRNA export from nucleus|mRNA 3'-end processing|cytoplasmic ribonucleoprotein granule|protein-containing complex binding|positive regulation of translation POLE 1989.698199 2223.364467 1756.031932 0.7898084 -0.340425384 0.150263616 1 13.40907167 10.41337813 5426 "DNA polymerase epsilon, catalytic subunit" "GO:0000082,GO:0000166,GO:0000278,GO:0000731,GO:0003677,GO:0003682,GO:0003887,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0006260,GO:0006270,GO:0006272,GO:0006287,GO:0006297,GO:0008270,GO:0008310,GO:0008622,GO:0032201,GO:0045004,GO:0048568,GO:0051539,GO:0090305" "G1/S transition of mitotic cell cycle|nucleotide binding|mitotic cell cycle|DNA synthesis involved in DNA repair|DNA binding|chromatin binding|DNA-directed DNA polymerase activity|protein binding|nucleus|nucleoplasm|plasma membrane|DNA replication|DNA replication initiation|leading strand elongation|base-excision repair, gap-filling|nucleotide-excision repair, DNA gap filling|zinc ion binding|single-stranded DNA 3'-5' exodeoxyribonuclease activity|epsilon DNA polymerase complex|telomere maintenance via semi-conservative replication|DNA replication proofreading|embryonic organ development|4 iron, 4 sulfur cluster binding|nucleic acid phosphodiester bond hydrolysis" "hsa03030,hsa03410,hsa03420" DNA replication|Base excision repair|Nucleotide excision repair POLE2 278.6591566 288.1946455 269.1236677 0.933826051 -0.098774259 0.768953996 1 7.895492069 7.249638738 5427 "DNA polymerase epsilon 2, accessory subunit" "GO:0000082,GO:0003677,GO:0003887,GO:0005515,GO:0005654,GO:0006260,GO:0006261,GO:0006270,GO:0006281,GO:0008622,GO:0016604,GO:0032201,GO:0042276,GO:0043231" G1/S transition of mitotic cell cycle|DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleoplasm|DNA replication|DNA-dependent DNA replication|DNA replication initiation|DNA repair|epsilon DNA polymerase complex|nuclear body|telomere maintenance via semi-conservative replication|error-prone translesion synthesis|intracellular membrane-bounded organelle "hsa03030,hsa03410,hsa03420" DNA replication|Base excision repair|Nucleotide excision repair POLE3 1648.704143 1686.510904 1610.897382 0.955165708 -0.066177052 0.782726385 1 41.0236952 38.52872857 54107 "DNA polymerase epsilon 3, accessory subunit" "GO:0000082,GO:0003887,GO:0005515,GO:0005634,GO:0005654,GO:0005671,GO:0006260,GO:0006270,GO:0006272,GO:0006974,GO:0008622,GO:0008623,GO:0031490,GO:0031507,GO:0032201,GO:0042766,GO:0043966,GO:0046982,GO:0071897" G1/S transition of mitotic cell cycle|DNA-directed DNA polymerase activity|protein binding|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|DNA replication|DNA replication initiation|leading strand elongation|cellular response to DNA damage stimulus|epsilon DNA polymerase complex|CHRAC|chromatin DNA binding|heterochromatin assembly|telomere maintenance via semi-conservative replication|nucleosome mobilization|histone H3 acetylation|protein heterodimerization activity|DNA biosynthetic process "hsa03030,hsa03410,hsa03420" DNA replication|Base excision repair|Nucleotide excision repair POLE4 189.163441 159.183324 219.143558 1.376674091 0.461187062 0.215176487 1 7.74413987 10.4827567 56655 "DNA polymerase epsilon 4, accessory subunit" "GO:0000082,GO:0003677,GO:0003887,GO:0005515,GO:0005634,GO:0005654,GO:0005671,GO:0006270,GO:0008622,GO:0032201,GO:0046982,GO:0071897" G1/S transition of mitotic cell cycle|DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|DNA replication initiation|epsilon DNA polymerase complex|telomere maintenance via semi-conservative replication|protein heterodimerization activity|DNA biosynthetic process "hsa03030,hsa03410,hsa03420" DNA replication|Base excision repair|Nucleotide excision repair POLG 1194.635253 1196.475965 1192.794541 0.996923111 -0.004445856 0.989280914 1 14.31056101 14.02779796 5428 "DNA polymerase gamma, catalytic subunit" "GO:0002020,GO:0003677,GO:0003682,GO:0003887,GO:0005515,GO:0005739,GO:0005760,GO:0006259,GO:0006261,GO:0006264,GO:0006287,GO:0007568,GO:0008408,GO:0009416,GO:0010332,GO:0032991,GO:0042645,GO:0043195,GO:0055093,GO:0071333,GO:0071897,GO:0090305" "protease binding|DNA binding|chromatin binding|DNA-directed DNA polymerase activity|protein binding|mitochondrion|gamma DNA polymerase complex|DNA metabolic process|DNA-dependent DNA replication|mitochondrial DNA replication|base-excision repair, gap-filling|aging|3'-5' exonuclease activity|response to light stimulus|response to gamma radiation|protein-containing complex|mitochondrial nucleoid|terminal bouton|response to hyperoxia|cellular response to glucose stimulus|DNA biosynthetic process|nucleic acid phosphodiester bond hydrolysis" POLG2 252.8368935 266.345954 239.327833 0.898560048 -0.154313178 0.651180073 1 8.985078407 7.938531174 11232 "DNA polymerase gamma 2, accessory subunit" "GO:0001701,GO:0003690,GO:0003887,GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0005760,GO:0006261,GO:0006264,GO:0006281,GO:0007005,GO:0022904,GO:0030337,GO:0032042,GO:0042645,GO:0042802,GO:0070182,GO:0070584,GO:0071897,GO:1900264" in utero embryonic development|double-stranded DNA binding|DNA-directed DNA polymerase activity|protein binding|cytoplasm|mitochondrion|mitochondrial matrix|gamma DNA polymerase complex|DNA-dependent DNA replication|mitochondrial DNA replication|DNA repair|mitochondrion organization|respiratory electron transport chain|DNA polymerase processivity factor activity|mitochondrial DNA metabolic process|mitochondrial nucleoid|identical protein binding|DNA polymerase binding|mitochondrion morphogenesis|DNA biosynthetic process|positive regulation of DNA-directed DNA polymerase activity POLH 755.9593356 769.9062732 742.012398 0.963769778 -0.053239533 0.838385972 1 3.682753677 3.489933518 5429 DNA polymerase eta "GO:0000731,GO:0003684,GO:0003887,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0005829,GO:0006260,GO:0006281,GO:0006282,GO:0006290,GO:0009314,GO:0010225,GO:0019985,GO:0035861,GO:0042276,GO:0046872,GO:0070987,GO:0071494" DNA synthesis involved in DNA repair|damaged DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleus|nucleoplasm|replication fork|cytosol|DNA replication|DNA repair|regulation of DNA repair|pyrimidine dimer repair|response to radiation|response to UV-C|translesion synthesis|site of double-strand break|error-prone translesion synthesis|metal ion binding|error-free translesion synthesis|cellular response to UV-C "hsa01524,hsa03460" Platinum drug resistance|Fanconi anemia pathway POLI 403.2766935 418.2463808 388.3070062 0.928416895 -0.107155318 0.716642403 1 4.63765648 4.233628929 11201 DNA polymerase iota "GO:0003684,GO:0003887,GO:0005515,GO:0005654,GO:0006260,GO:0006281,GO:0016607,GO:0019985,GO:0036464,GO:0042276,GO:0046872" damaged DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleoplasm|DNA replication|DNA repair|nuclear speck|translesion synthesis|cytoplasmic ribonucleoprotein granule|error-prone translesion synthesis|metal ion binding hsa03460 Fanconi anemia pathway POLK 813.2865092 824.0077951 802.5652233 0.973977708 -0.038039343 0.884417068 1 9.007738951 8.626527022 51426 DNA polymerase kappa "GO:0003684,GO:0003887,GO:0005634,GO:0005654,GO:0006260,GO:0006281,GO:0006283,GO:0006296,GO:0006297,GO:0006974,GO:0016604,GO:0019985,GO:0033683,GO:0034644,GO:0042276,GO:0046872,GO:0090734" "damaged DNA binding|DNA-directed DNA polymerase activity|nucleus|nucleoplasm|DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|cellular response to DNA damage stimulus|nuclear body|translesion synthesis|nucleotide-excision repair, DNA incision|cellular response to UV|error-prone translesion synthesis|metal ion binding|site of DNA damage" "hsa03460,hsa05169,hsa05200,hsa05202,hsa05210,hsa05212,hsa05213,hsa05214,hsa05216,hsa05217,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" Fanconi anemia pathway|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Thyroid cancer|Basal cell carcinoma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer POLL 1047.886592 1027.928916 1067.844267 1.038830848 0.05496076 0.825843398 1 19.04154009 19.449932 27343 DNA polymerase lambda "GO:0000724,GO:0003677,GO:0003887,GO:0005634,GO:0005654,GO:0006260,GO:0006287,GO:0006289,GO:0006303,GO:0016446,GO:0046872,GO:0051575,GO:0071897" "double-strand break repair via homologous recombination|DNA binding|DNA-directed DNA polymerase activity|nucleus|nucleoplasm|DNA replication|base-excision repair, gap-filling|nucleotide-excision repair|double-strand break repair via nonhomologous end joining|somatic hypermutation of immunoglobulin genes|metal ion binding|5'-deoxyribose-5-phosphate lyase activity|DNA biosynthetic process" "hsa03410,hsa03450" Base excision repair|Non-homologous end-joining POLM 917.8644244 793.8357925 1041.893056 1.312479314 0.392294685 0.113488208 1 14.81831313 19.1232813 27434 DNA polymerase mu "GO:0003677,GO:0003887,GO:0005515,GO:0005634,GO:0005654,GO:0006303,GO:0006310,GO:0046872,GO:0071897" DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleus|nucleoplasm|double-strand break repair via nonhomologous end joining|DNA recombination|metal ion binding|DNA biosynthetic process hsa03450 Non-homologous end-joining POLN 8.045908318 9.363724944 6.728091692 0.718527267 -0.476885189 0.786592357 1 0.153619671 0.108532864 353497 DNA polymerase nu "GO:0000724,GO:0003677,GO:0003887,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006261,GO:0019985,GO:0030332,GO:0036297" double-strand break repair via homologous recombination|DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|DNA-dependent DNA replication|translesion synthesis|cyclin binding|interstrand cross-link repair hsa03460 Fanconi anemia pathway POLQ 803.1742499 873.9476614 732.4008385 0.838037414 -0.25491344 0.311311733 1 5.326136855 4.388811298 10721 DNA polymerase theta "GO:0000724,GO:0003682,GO:0003684,GO:0003887,GO:0005515,GO:0005524,GO:0005654,GO:0005694,GO:0005737,GO:0005794,GO:0005829,GO:0006261,GO:0006281,GO:0006284,GO:0006302,GO:0006974,GO:0008409,GO:0016446,GO:0017116,GO:0032508,GO:0051260,GO:0051575,GO:0071897,GO:0090305,GO:0097681,GO:2000042" double-strand break repair via homologous recombination|chromatin binding|damaged DNA binding|DNA-directed DNA polymerase activity|protein binding|ATP binding|nucleoplasm|chromosome|cytoplasm|Golgi apparatus|cytosol|DNA-dependent DNA replication|DNA repair|base-excision repair|double-strand break repair|cellular response to DNA damage stimulus|5'-3' exonuclease activity|somatic hypermutation of immunoglobulin genes|single-stranded DNA helicase activity|DNA duplex unwinding|protein homooligomerization|5'-deoxyribose-5-phosphate lyase activity|DNA biosynthetic process|nucleic acid phosphodiester bond hydrolysis|double-strand break repair via alternative nonhomologous end joining|negative regulation of double-strand break repair via homologous recombination POLR1A 1293.711731 1501.317233 1086.10623 0.723435532 -0.467063637 0.052399043 1 6.420075433 4.566791087 25885 RNA polymerase I subunit A "GO:0001054,GO:0003677,GO:0003682,GO:0003899,GO:0005515,GO:0005654,GO:0005694,GO:0005736,GO:0006361,GO:0006362,GO:0006363,GO:0008270,GO:0045815,GO:1904750" "RNA polymerase I activity|DNA binding|chromatin binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|chromosome|RNA polymerase I complex|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|zinc ion binding|positive regulation of gene expression, epigenetic|negative regulation of protein localization to nucleolus" hsa03020 RNA polymerase POLR1B 916.7429094 1092.434577 741.0512421 0.678348395 -0.559901673 0.02393788 0.848442542 7.177302173 4.787240119 84172 RNA polymerase I subunit B "GO:0003677,GO:0003899,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0005736,GO:0005829,GO:0006361,GO:0006362,GO:0006363,GO:0007566,GO:0009303,GO:0017126,GO:0032549,GO:0045815,GO:0046872" "DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|chromosome|nucleolus|RNA polymerase I complex|cytosol|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|embryo implantation|rRNA transcription|nucleologenesis|ribonucleoside binding|positive regulation of gene expression, epigenetic|metal ion binding" hsa03020 RNA polymerase POLR1C 259.8524488 248.658918 271.0459796 1.090031203 0.124369435 0.715432746 1 5.405486532 5.793551856 9533 RNA polymerase I and III subunit C "GO:0001054,GO:0001056,GO:0003677,GO:0003899,GO:0005515,GO:0005654,GO:0005666,GO:0005736,GO:0005829,GO:0006360,GO:0006361,GO:0006362,GO:0006363,GO:0006383,GO:0032481,GO:0045815,GO:0046983" "RNA polymerase I activity|RNA polymerase III activity|DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|RNA polymerase III complex|RNA polymerase I complex|cytosol|transcription by RNA polymerase I|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase III|positive regulation of type I interferon production|positive regulation of gene expression, epigenetic|protein dimerization activity" "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLR1D 2007.615406 1886.270369 2128.960443 1.12866134 0.174612664 0.461073242 1 27.77780982 30.82711114 51082 RNA polymerase I and III subunit D "GO:0003677,GO:0003899,GO:0005515,GO:0005666,GO:0005736,GO:0006351,GO:0046983" "DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|RNA polymerase III complex|RNA polymerase I complex|transcription, DNA-templated|protein dimerization activity" "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLR1E 1453.837933 1566.863307 1340.812559 0.855730396 -0.224771758 0.347344296 1 42.90436887 36.10020392 64425 RNA polymerase I subunit E "GO:0001179,GO:0001188,GO:0001650,GO:0003677,GO:0003899,GO:0005515,GO:0005654,GO:0005730,GO:0005736,GO:0006361,GO:0006362,GO:0006363,GO:0042790,GO:0045815" "RNA polymerase I general transcription initiation factor binding|RNA polymerase I preinitiation complex assembly|fibrillar center|DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|nucleolus|RNA polymerase I complex|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|nucleolar large rRNA transcription by RNA polymerase I|positive regulation of gene expression, epigenetic" hsa03020 RNA polymerase POLR1F 1141.06903 1051.858435 1230.279624 1.169624716 0.226045703 0.353029445 1 14.41966387 16.58337237 221830 RNA polymerase I subunit F "GO:0003899,GO:0005654,GO:0005736,GO:0006361,GO:0006362,GO:0006363,GO:0045815" "DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|RNA polymerase I complex|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|positive regulation of gene expression, epigenetic" hsa03020 RNA polymerase POLR1G 188.7074007 197.6786377 179.7361638 0.909234128 -0.137276258 0.72234109 1 3.738393188 3.342195759 10849 RNA polymerase I subunit G "GO:0000120,GO:0001650,GO:0003723,GO:0003899,GO:0005654,GO:0005694,GO:0005730,GO:0005736,GO:0005739,GO:0005829,GO:0006361,GO:0006362,GO:0006363,GO:0007169,GO:0009303,GO:0045815" "RNA polymerase I transcription regulator complex|fibrillar center|RNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|chromosome|nucleolus|RNA polymerase I complex|mitochondrion|cytosol|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transmembrane receptor protein tyrosine kinase signaling pathway|rRNA transcription|positive regulation of gene expression, epigenetic" POLR1H 209.4169132 186.234085 232.5997414 1.248964395 0.32073235 0.372334988 1 13.69004247 16.81225745 30834 RNA polymerase I subunit H "GO:0003676,GO:0003899,GO:0005515,GO:0005654,GO:0005736,GO:0006139,GO:0006361,GO:0006362,GO:0006363,GO:0006379,GO:0008270,GO:0045815" "nucleic acid binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|RNA polymerase I complex|nucleobase-containing compound metabolic process|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|mRNA cleavage|zinc ion binding|positive regulation of gene expression, epigenetic" hsa03020 RNA polymerase POLR2A 4178.149435 4958.612565 3397.686304 0.68520907 -0.545383846 0.022424344 0.824335762 39.21055549 26.41783824 5430 RNA polymerase II subunit A "GO:0000398,GO:0000974,GO:0001055,GO:0001172,GO:0003677,GO:0003723,GO:0003899,GO:0003968,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0005694,GO:0005730,GO:0005737,GO:0006283,GO:0006351,GO:0006353,GO:0006355,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008022,GO:0008543,GO:0016032,GO:0016070,GO:0019900,GO:0031625,GO:0033120,GO:0035019,GO:0042795,GO:0046872,GO:0050434,GO:0060964,GO:1990841" "mRNA splicing, via spliceosome|Prp19 complex|RNA polymerase II activity|transcription, RNA-templated|DNA binding|RNA binding|DNA-directed 5'-3' RNA polymerase activity|RNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|chromosome|nucleolus|cytoplasm|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|DNA-templated transcription, termination|regulation of transcription, DNA-templated|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|protein C-terminus binding|fibroblast growth factor receptor signaling pathway|viral process|RNA metabolic process|kinase binding|ubiquitin protein ligase binding|positive regulation of RNA splicing|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|metal ion binding|positive regulation of viral transcription|regulation of gene silencing by miRNA|promoter-specific chromatin binding" "hsa03020,hsa05016" RNA polymerase|Huntington disease other POLR2B 3357.817687 3331.405252 3384.230121 1.015856633 0.022696809 0.925035577 1 44.86272406 44.81147501 5431 RNA polymerase II subunit B "GO:0000398,GO:0000781,GO:0001055,GO:0003677,GO:0003682,GO:0003723,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0006283,GO:0006351,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0016020,GO:0016070,GO:0032549,GO:0035019,GO:0042795,GO:0046872,GO:0050434,GO:0060964" "mRNA splicing, via spliceosome|chromosome, telomeric region|RNA polymerase II activity|DNA binding|chromatin binding|RNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|membrane|RNA metabolic process|ribonucleoside binding|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|metal ion binding|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa05016" RNA polymerase|Huntington disease POLR2C 1245.650746 1211.041759 1280.259733 1.057155728 0.080187914 0.742262194 1 36.63893021 38.08490974 5432 RNA polymerase II subunit C "GO:0000398,GO:0003677,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0005829,GO:0006283,GO:0006351,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0016070,GO:0035019,GO:0042795,GO:0046983,GO:0050434,GO:0060964" "mRNA splicing, via spliceosome|DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|cytosol|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|RNA metabolic process|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|protein dimerization activity|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa05016" RNA polymerase|Huntington disease POLR2D 1132.889143 1076.828369 1188.949918 1.104122024 0.142899623 0.558505279 1 11.40697715 12.38393954 5433 RNA polymerase II subunit D "GO:0000166,GO:0000288,GO:0000398,GO:0000932,GO:0003697,GO:0003727,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0005829,GO:0006283,GO:0006351,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0016070,GO:0016607,GO:0031369,GO:0031990,GO:0034402,GO:0035019,GO:0042795,GO:0045948,GO:0050434,GO:0060964" "nucleotide binding|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|mRNA splicing, via spliceosome|P-body|single-stranded DNA binding|single-stranded RNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|cytosol|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|RNA metabolic process|nuclear speck|translation initiation factor binding|mRNA export from nucleus in response to heat stress|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|positive regulation of translational initiation|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa05016" RNA polymerase|Huntington disease POLR2E 2003.661956 1858.179194 2149.144718 1.156586364 0.209872998 0.37541646 1 32.92417278 37.44243791 5434 "RNA polymerase II, I and III subunit E" "GO:0000398,GO:0003677,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0005666,GO:0005736,GO:0005829,GO:0006283,GO:0006351,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0016032,GO:0016070,GO:0032481,GO:0035019,GO:0042795,GO:0045815,GO:0050434,GO:0060964" "mRNA splicing, via spliceosome|DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|RNA polymerase III complex|RNA polymerase I complex|cytosol|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|viral process|RNA metabolic process|positive regulation of type I interferon production|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|positive regulation of gene expression, epigenetic|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa04623,hsa05016" RNA polymerase|Cytosolic DNA-sensing pathway|Huntington disease POLR2F 642.5837905 569.1063938 716.0611872 1.258220247 0.331384483 0.20228019 1 9.226051721 11.41415413 5435 "RNA polymerase II, I and III subunit F" "GO:0000398,GO:0001650,GO:0003677,GO:0003899,GO:0005634,GO:0005654,GO:0005665,GO:0005666,GO:0005736,GO:0005829,GO:0006283,GO:0006351,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0016070,GO:0032481,GO:0035019,GO:0042795,GO:0045815,GO:0050434,GO:0060964" "mRNA splicing, via spliceosome|fibrillar center|DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|nucleoplasm|RNA polymerase II, core complex|RNA polymerase III complex|RNA polymerase I complex|cytosol|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|RNA metabolic process|positive regulation of type I interferon production|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|positive regulation of gene expression, epigenetic|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa04623,hsa05016" RNA polymerase|Cytosolic DNA-sensing pathway|Huntington disease POLR2G 1107.913565 1140.293615 1075.533515 0.943207522 -0.084352872 0.731894978 1 76.93473386 71.35113562 5436 RNA polymerase II subunit G "GO:0000291,GO:0000398,GO:0000932,GO:0003697,GO:0003727,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0006283,GO:0006351,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006915,GO:0008543,GO:0016070,GO:0031369,GO:0035019,GO:0042795,GO:0045948,GO:0050434,GO:0060213,GO:0060964" "nuclear-transcribed mRNA catabolic process, exonucleolytic|mRNA splicing, via spliceosome|P-body|single-stranded DNA binding|single-stranded RNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|apoptotic process|fibroblast growth factor receptor signaling pathway|RNA metabolic process|translation initiation factor binding|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|positive regulation of translational initiation|positive regulation of viral transcription|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of gene silencing by miRNA" "hsa03020,hsa05016" RNA polymerase|Huntington disease POLR2H 885.1058639 791.7549647 978.4567632 1.23580755 0.305454093 0.219720189 1 18.64717885 22.65870885 5437 "RNA polymerase II, I and III subunit H" "GO:0000398,GO:0003697,GO:0003899,GO:0005634,GO:0005654,GO:0005665,GO:0005666,GO:0005736,GO:0005829,GO:0006283,GO:0006351,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0016070,GO:0032481,GO:0032993,GO:0035019,GO:0042795,GO:0045815,GO:0050434,GO:0060964" "mRNA splicing, via spliceosome|single-stranded DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|nucleoplasm|RNA polymerase II, core complex|RNA polymerase III complex|RNA polymerase I complex|cytosol|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|RNA metabolic process|positive regulation of type I interferon production|protein-DNA complex|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|positive regulation of gene expression, epigenetic|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa04623,hsa05016" RNA polymerase|Cytosolic DNA-sensing pathway|Huntington disease POLR2I 298.8981519 251.7801596 346.0161442 1.374278834 0.458674749 0.145559707 1 30.33192859 40.98699334 5438 RNA polymerase II subunit I "GO:0000398,GO:0001193,GO:0003676,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0005730,GO:0006283,GO:0006351,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006379,GO:0008270,GO:0008543,GO:0016070,GO:0035019,GO:0042795,GO:0050434,GO:0060964" "mRNA splicing, via spliceosome|maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter|nucleic acid binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|nucleolus|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|mRNA cleavage|zinc ion binding|fibroblast growth factor receptor signaling pathway|RNA metabolic process|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa05016" RNA polymerase|Huntington disease POLR2J 816.4033348 741.8150983 890.9915712 1.201096571 0.264352152 0.292852234 1 24.36265132 28.77223876 5439 RNA polymerase II subunit J "GO:0000398,GO:0001055,GO:0003677,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0006283,GO:0006351,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0016070,GO:0030275,GO:0035019,GO:0042795,GO:0046983,GO:0050434,GO:0060964" "mRNA splicing, via spliceosome|RNA polymerase II activity|DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|RNA metabolic process|LRR domain binding|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|protein dimerization activity|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa05016" RNA polymerase|Huntington disease POLR2J2 25.10391133 15.60620824 34.60161442 2.217169852 1.148719296 0.143912887 1 0.417899975 0.91105058 246721 RNA polymerase II subunit J2 "GO:0001055,GO:0003677,GO:0003899,GO:0005665,GO:0006366,GO:0046983" "RNA polymerase II activity|DNA binding|DNA-directed 5'-3' RNA polymerase activity|RNA polymerase II, core complex|transcription by RNA polymerase II|protein dimerization activity" "hsa03020,hsa05016" RNA polymerase|Huntington disease POLR2J3 30.70227037 36.41448589 24.99005486 0.686266859 -0.543158409 0.464786672 1 1.156770348 0.780569096 548644 RNA polymerase II subunit J3 "GO:0001055,GO:0003677,GO:0003899,GO:0005515,GO:0005665,GO:0006366,GO:0046983" "RNA polymerase II activity|DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|RNA polymerase II, core complex|transcription by RNA polymerase II|protein dimerization activity" "hsa03020,hsa05016" RNA polymerase|Huntington disease POLR2K 1200.650638 1076.828369 1324.472907 1.229975868 0.29863001 0.217565983 1 60.68463664 73.39162863 5440 "RNA polymerase II, I and III subunit K" "GO:0000398,GO:0003677,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0005666,GO:0005736,GO:0005829,GO:0006283,GO:0006351,GO:0006356,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006383,GO:0008270,GO:0008543,GO:0016070,GO:0032481,GO:0035019,GO:0042795,GO:0045815,GO:0050434,GO:0060964" "mRNA splicing, via spliceosome|DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|RNA polymerase III complex|RNA polymerase I complex|cytosol|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|regulation of transcription by RNA polymerase I|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|transcription by RNA polymerase III|zinc ion binding|fibroblast growth factor receptor signaling pathway|RNA metabolic process|positive regulation of type I interferon production|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|positive regulation of gene expression, epigenetic|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa04623,hsa05016" RNA polymerase|Cytosolic DNA-sensing pathway|Huntington disease POLR2L 2225.288276 1759.339876 2691.236677 1.529685488 0.613235058 0.00964727 0.604180798 107.1834882 161.2134276 5441 "RNA polymerase II, I and III subunit L" "GO:0000398,GO:0003677,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005665,GO:0005666,GO:0005736,GO:0005829,GO:0006283,GO:0006351,GO:0006356,GO:0006360,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008270,GO:0008543,GO:0016070,GO:0032481,GO:0035019,GO:0042795,GO:0042797,GO:0045815,GO:0050434,GO:0060964" "mRNA splicing, via spliceosome|DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase II, core complex|RNA polymerase III complex|RNA polymerase I complex|cytosol|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|regulation of transcription by RNA polymerase I|transcription by RNA polymerase I|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|zinc ion binding|fibroblast growth factor receptor signaling pathway|RNA metabolic process|positive regulation of type I interferon production|somatic stem cell population maintenance|snRNA transcription by RNA polymerase II|tRNA transcription by RNA polymerase III|positive regulation of gene expression, epigenetic|positive regulation of viral transcription|regulation of gene silencing by miRNA" "hsa03020,hsa04623,hsa05016" RNA polymerase|Cytosolic DNA-sensing pathway|Huntington disease POLR2M 30.58338348 33.29324424 27.87352272 0.837212574 -0.256334115 0.757078714 1 0.431890922 0.355533884 81488 RNA polymerase II subunit M "GO:0003899,GO:0005622,GO:0005635,GO:0005665,GO:0016591,GO:0032774,GO:0035556,GO:0043025,GO:0051685" "DNA-directed 5'-3' RNA polymerase activity|intracellular anatomical structure|nuclear envelope|RNA polymerase II, core complex|RNA polymerase II, holoenzyme|RNA biosynthetic process|intracellular signal transduction|neuronal cell body|maintenance of ER location" POLR3A 2264.939819 2346.133305 2183.746332 0.930785274 -0.103479709 0.662579857 1 18.94233321 17.3362098 11128 RNA polymerase III subunit A "GO:0003677,GO:0003682,GO:0003899,GO:0005654,GO:0005666,GO:0005829,GO:0006351,GO:0016020,GO:0032481,GO:0032728,GO:0045087,GO:0046872,GO:0051607" "DNA binding|chromatin binding|DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|RNA polymerase III complex|cytosol|transcription, DNA-templated|membrane|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|metal ion binding|defense response to virus" "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway other POLR3B 311.6403995 333.9728563 289.3079428 0.866261845 -0.20712492 0.509483344 1 2.778412709 2.36655783 55703 RNA polymerase III subunit B "GO:0003677,GO:0003899,GO:0005654,GO:0005666,GO:0005829,GO:0006351,GO:0032481,GO:0032549,GO:0032728,GO:0045087,GO:0045089,GO:0046872,GO:0051607" "DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|RNA polymerase III complex|cytosol|transcription, DNA-templated|positive regulation of type I interferon production|ribonucleoside binding|positive regulation of interferon-beta production|innate immune response|positive regulation of innate immune response|metal ion binding|defense response to virus" "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLR3C 600.9263775 686.6731625 515.1795924 0.750254445 -0.414548134 0.114621753 1 9.759383391 7.199496667 10623 RNA polymerase III subunit C "GO:0003697,GO:0003899,GO:0005515,GO:0005654,GO:0005666,GO:0005829,GO:0006351,GO:0006359,GO:0032481,GO:0032728,GO:0045087,GO:0045089,GO:0051607" "single-stranded DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|RNA polymerase III complex|cytosol|transcription, DNA-templated|regulation of transcription by RNA polymerase III|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|positive regulation of innate immune response|defense response to virus" "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLR3D 836.9782547 865.6243504 808.332159 0.933814025 -0.098792838 0.696295485 1 8.657567584 7.949273905 661 RNA polymerase III subunit D "GO:0003677,GO:0003682,GO:0003899,GO:0005654,GO:0005666,GO:0005829,GO:0006383,GO:0032481,GO:0032728,GO:0045087,GO:0045089,GO:0051607" DNA binding|chromatin binding|DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|RNA polymerase III complex|cytosol|transcription by RNA polymerase III|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|positive regulation of innate immune response|defense response to virus "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLR3E 787.1220623 856.2606254 717.9834991 0.83851047 -0.254099298 0.314090303 1 9.339271579 7.70003453 55718 RNA polymerase III subunit E "GO:0003899,GO:0005654,GO:0005666,GO:0005829,GO:0006351,GO:0032481,GO:0045087,GO:0051607" "DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|RNA polymerase III complex|cytosol|transcription, DNA-templated|positive regulation of type I interferon production|innate immune response|defense response to virus" "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLR3F 456.6208491 418.2463808 494.9953173 1.183501735 0.243061821 0.38615869 1 10.07267177 11.72154231 10621 RNA polymerase III subunit F "GO:0003690,GO:0003899,GO:0005515,GO:0005654,GO:0005666,GO:0005829,GO:0006359,GO:0006383,GO:0032481,GO:0032728,GO:0045087,GO:0045089,GO:0051607" double-stranded DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|RNA polymerase III complex|cytosol|regulation of transcription by RNA polymerase III|transcription by RNA polymerase III|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|positive regulation of innate immune response|defense response to virus "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLR3G 1402.864526 1149.65734 1656.071712 1.440491574 0.526561222 0.028059441 0.877967194 13.0127464 18.43108352 10622 RNA polymerase III subunit G "GO:0003682,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005666,GO:0005829,GO:0006359,GO:0006383,GO:0008283,GO:0016604,GO:0032481,GO:0032728,GO:0045087,GO:0045089,GO:0051607" chromatin binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|RNA polymerase III complex|cytosol|regulation of transcription by RNA polymerase III|transcription by RNA polymerase III|cell population proliferation|nuclear body|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|positive regulation of innate immune response|defense response to virus "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway other POLR3GL 425.8191991 429.6909335 421.9474647 0.98197898 -0.026235952 0.935276378 1 18.40434622 17.77025928 84265 RNA polymerase III subunit GL "GO:0005515,GO:0005634,GO:0005654,GO:0005666,GO:0005829,GO:0006383,GO:0032481" protein binding|nucleus|nucleoplasm|RNA polymerase III complex|cytosol|transcription by RNA polymerase III|positive regulation of type I interferon production "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLR3H 596.09606 648.1778489 544.0142711 0.839297844 -0.25274522 0.338001605 1 6.661286442 5.497248827 171568 RNA polymerase III subunit H "GO:0003677,GO:0003899,GO:0005515,GO:0005654,GO:0005666,GO:0005813,GO:0005829,GO:0006139,GO:0006383,GO:0006384,GO:0032481,GO:0043231,GO:0045087,GO:0051607" DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|RNA polymerase III complex|centrosome|cytosol|nucleobase-containing compound metabolic process|transcription by RNA polymerase III|transcription initiation from RNA polymerase III promoter|positive regulation of type I interferon production|intracellular membrane-bounded organelle|innate immune response|defense response to virus "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLR3K 290.7924929 291.3158871 290.2690987 0.99640669 -0.005193388 0.999405716 1 11.3316279 11.10197176 51728 RNA polymerase III subunit K "GO:0003676,GO:0003899,GO:0005515,GO:0005654,GO:0005666,GO:0005730,GO:0005829,GO:0006383,GO:0006386,GO:0008270,GO:0032481,GO:0042779,GO:0045087,GO:0051607" nucleic acid binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleoplasm|RNA polymerase III complex|nucleolus|cytosol|transcription by RNA polymerase III|termination of RNA polymerase III transcription|zinc ion binding|positive regulation of type I interferon production|tRNA 3'-trailer cleavage|innate immune response|defense response to virus "hsa03020,hsa04623" RNA polymerase|Cytosolic DNA-sensing pathway POLRMT 754.5176017 769.9062732 739.1289302 0.960024559 -0.058856782 0.821040199 1 10.90458672 10.29349202 5442 RNA polymerase mitochondrial "GO:0001018,GO:0003723,GO:0003899,GO:0005515,GO:0005739,GO:0005759,GO:0006390,GO:0006391,GO:0007005,GO:0032991,GO:0034245,GO:0042645,GO:0043565" mitochondrial promoter sequence-specific DNA binding|RNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|mitochondrion|mitochondrial matrix|mitochondrial transcription|transcription initiation from mitochondrial promoter|mitochondrion organization|protein-containing complex|mitochondrial DNA-directed RNA polymerase complex|mitochondrial nucleoid|sequence-specific DNA binding POM121 867.3930615 919.7258723 815.0602507 0.886199111 -0.174297215 0.486014728 1 4.834440995 4.212585734 9883 POM121 transmembrane nucleoporin "GO:0005515,GO:0005635,GO:0005643,GO:0005654,GO:0005789,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0008139,GO:0016021,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0043657,GO:0060964,GO:0075733,GO:1900034" protein binding|nuclear envelope|nuclear pore|nucleoplasm|endoplasmic reticulum membrane|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|nuclear localization sequence binding|integral component of membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|host cell|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis POM121C 1546.812165 1610.56069 1483.06364 0.920836855 -0.118982519 0.618964067 1 14.65018987 13.2646906 100101267 POM121 transmembrane nucleoporin C "GO:0005515,GO:0005635,GO:0005643,GO:0005789,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0008139,GO:0016021,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0043657,GO:0060964,GO:0075733,GO:1900034" protein binding|nuclear envelope|nuclear pore|endoplasmic reticulum membrane|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|nuclear localization sequence binding|integral component of membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|host cell|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis POMGNT1 2644.249207 2412.719794 2875.77862 1.191923997 0.253292245 0.28417726 1 36.15906234 42.37765316 55624 "protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)" "GO:0000139,GO:0005515,GO:0006493,GO:0008375,GO:0016021,GO:0016266,GO:0018215,GO:0030145,GO:0030173,GO:0047223" "Golgi membrane|protein binding|protein O-linked glycosylation|acetylglucosaminyltransferase activity|integral component of membrane|O-glycan processing|protein phosphopantetheinylation|manganese ion binding|integral component of Golgi membrane|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity" hsa00515 Mannose type O-glycan biosynthesis POMGNT2 526.9286585 459.8629361 593.9943808 1.291677007 0.369245359 0.171766592 1 8.847166442 11.23645469 84892 "protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)" "GO:0001764,GO:0005515,GO:0005783,GO:0005789,GO:0006493,GO:0008375,GO:0016021,GO:0016757,GO:0018215,GO:0035269,GO:0097363" "neuron migration|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein O-linked glycosylation|acetylglucosaminyltransferase activity|integral component of membrane|transferase activity, transferring glycosyl groups|protein phosphopantetheinylation|protein O-linked mannosylation|protein O-GlcNAc transferase activity" hsa00515 Mannose type O-glycan biosynthesis POMK 27.17970867 32.25283036 22.10658699 0.685415411 -0.544949464 0.487040553 1 0.92145304 0.62100951 84197 protein O-mannose kinase "GO:0004672,GO:0005515,GO:0005524,GO:0005789,GO:0006468,GO:0006493,GO:0007420,GO:0016021,GO:0016773,GO:0019200,GO:0046835" "protein kinase activity|protein binding|ATP binding|endoplasmic reticulum membrane|protein phosphorylation|protein O-linked glycosylation|brain development|integral component of membrane|phosphotransferase activity, alcohol group as acceptor|carbohydrate kinase activity|carbohydrate phosphorylation" hsa00515 Mannose type O-glycan biosynthesis POMP 1842.645639 1516.923441 2168.367837 1.429451071 0.515461238 0.029791571 0.891465488 60.50479526 85.04137403 51371 proteasome maturation protein "GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0016607,GO:0031090,GO:0043248" protein binding|nucleus|cytoplasm|endoplasmic reticulum|cytosol|nuclear speck|organelle membrane|proteasome assembly hsa03050 Proteasome POMT1 566.6625308 544.1364606 589.188601 1.082795666 0.114761018 0.670487309 1 8.918784651 9.495620841 10585 protein O-mannosyltransferase 1 "GO:0000030,GO:0001669,GO:0004169,GO:0005783,GO:0005789,GO:0005975,GO:0006493,GO:0007275,GO:0016021,GO:0016529,GO:0030198,GO:0035269,GO:0046872,GO:1904100" mannosyltransferase activity|acrosomal vesicle|dolichyl-phosphate-mannose-protein mannosyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|carbohydrate metabolic process|protein O-linked glycosylation|multicellular organism development|integral component of membrane|sarcoplasmic reticulum|extracellular matrix organization|protein O-linked mannosylation|metal ion binding|positive regulation of protein O-linked glycosylation "hsa00514,hsa00515" Other types of O-glycan biosynthesis|Mannose type O-glycan biosynthesis POMT2 623.1273136 651.2990905 594.9555368 0.913490508 -0.130538358 0.620631195 1 6.867938238 6.168812901 29954 protein O-mannosyltransferase 2 "GO:0000030,GO:0004169,GO:0005654,GO:0005730,GO:0005789,GO:0005829,GO:0006493,GO:0016021,GO:0035269,GO:0046872,GO:0071712,GO:1904100" mannosyltransferase activity|dolichyl-phosphate-mannose-protein mannosyltransferase activity|nucleoplasm|nucleolus|endoplasmic reticulum membrane|cytosol|protein O-linked glycosylation|integral component of membrane|protein O-linked mannosylation|metal ion binding|ER-associated misfolded protein catabolic process|positive regulation of protein O-linked glycosylation "hsa00514,hsa00515" Other types of O-glycan biosynthesis|Mannose type O-glycan biosynthesis POMZP3 284.4707517 276.7500928 292.1914106 1.055795168 0.078329968 0.817137933 1 9.665997256 10.0345411 22932 POM121 and ZP3 fusion "GO:0003674,GO:0005654,GO:0007339,GO:0008150,GO:0031012,GO:0031965,GO:0032190,GO:0035803,GO:2000344" molecular_function|nucleoplasm|binding of sperm to zona pellucida|biological_process|extracellular matrix|nuclear membrane|acrosin binding|egg coat formation|positive regulation of acrosome reaction PON2 1677.697952 1589.752413 1765.643491 1.110640548 0.151391973 0.524889188 1 50.50128835 55.15020883 5445 paraoxonase 2 "GO:0004064,GO:0005576,GO:0005886,GO:0009636,GO:0019372,GO:0019439,GO:0042802,GO:0046872,GO:0102007" arylesterase activity|extracellular region|plasma membrane|response to toxic substance|lipoxygenase pathway|aromatic compound catabolic process|identical protein binding|metal ion binding|acyl-L-homoserine-lactone lactonohydrolase activity POP1 689.6055905 655.4607461 723.7504349 1.10418578 0.142982926 0.580569079 1 7.237892682 7.858243242 10940 "POP1 homolog, ribonuclease P/MRP subunit" "GO:0000172,GO:0001682,GO:0003723,GO:0004526,GO:0005515,GO:0005615,GO:0005654,GO:0005655,GO:0005730,GO:0008033,GO:0016078,GO:0030681,GO:0033204,GO:0090502" "ribonuclease MRP complex|tRNA 5'-leader removal|RNA binding|ribonuclease P activity|protein binding|extracellular space|nucleoplasm|nucleolar ribonuclease P complex|nucleolus|tRNA processing|tRNA catabolic process|multimeric ribonuclease P complex|ribonuclease P RNA binding|RNA phosphodiester bond hydrolysis, endonucleolytic" "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport POP4 458.1468714 407.842242 508.4515007 1.246686705 0.318098958 0.255159323 1 8.515567634 10.43859647 10775 "POP4 homolog, ribonuclease P/MRP subunit" "GO:0000171,GO:0000172,GO:0001682,GO:0004526,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0030677,GO:0030681,GO:0033204,GO:0090502" "ribonuclease MRP activity|ribonuclease MRP complex|tRNA 5'-leader removal|ribonuclease P activity|protein binding|nucleoplasm|nucleolus|rRNA processing|ribonuclease P complex|multimeric ribonuclease P complex|ribonuclease P RNA binding|RNA phosphodiester bond hydrolysis, endonucleolytic" "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport POP5 350.3193811 352.7003062 347.9384561 0.986498877 -0.019610686 0.958337194 1 15.81761942 15.34295092 51367 "POP5 homolog, ribonuclease P/MRP subunit" "GO:0000172,GO:0001682,GO:0004526,GO:0005515,GO:0005654,GO:0005655,GO:0005730,GO:0006364,GO:0008033,GO:0030681,GO:0033204,GO:0090502" "ribonuclease MRP complex|tRNA 5'-leader removal|ribonuclease P activity|protein binding|nucleoplasm|nucleolar ribonuclease P complex|nucleolus|rRNA processing|tRNA processing|multimeric ribonuclease P complex|ribonuclease P RNA binding|RNA phosphodiester bond hydrolysis, endonucleolytic" "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport POP7 641.9541431 640.8949517 643.0133346 1.003305351 0.00476075 0.992248321 1 40.23927724 39.69670672 10248 "POP7 homolog, ribonuclease P/MRP subunit" "GO:0000172,GO:0001682,GO:0003723,GO:0004526,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0008033,GO:0030681,GO:0033204,GO:0043231,GO:0090502" "ribonuclease MRP complex|tRNA 5'-leader removal|RNA binding|ribonuclease P activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|rRNA processing|tRNA processing|multimeric ribonuclease P complex|ribonuclease P RNA binding|intracellular membrane-bounded organelle|RNA phosphodiester bond hydrolysis, endonucleolytic" "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport POPDC2 2.080827765 4.161655531 0 0 #NAME? 0.234194363 1 0.116587878 0 64091 popeye domain containing 2 "GO:0002027,GO:0003674,GO:0007507,GO:0007519,GO:0008150,GO:0016021,GO:0030552,GO:0042383,GO:0042391,GO:0051146" regulation of heart rate|molecular_function|heart development|skeletal muscle tissue development|biological_process|integral component of membrane|cAMP binding|sarcolemma|regulation of membrane potential|striated muscle cell differentiation POPDC3 445.8594352 488.9945248 402.7243456 0.82357639 -0.280025623 0.320082505 1 5.393002492 4.367226208 64208 popeye domain containing 3 "GO:0003674,GO:0007507,GO:0007519,GO:0008150,GO:0016021,GO:0030552,GO:0042383,GO:0042391,GO:0051146" molecular_function|heart development|skeletal muscle tissue development|biological_process|integral component of membrane|cAMP binding|sarcolemma|regulation of membrane potential|striated muscle cell differentiation POR 966.5500264 1024.807674 908.2923784 0.886305207 -0.174124505 0.481469597 1 17.20418436 14.99300091 5447 cytochrome p450 oxidoreductase "GO:0003958,GO:0005515,GO:0005789,GO:0005829,GO:0006805,GO:0009725,GO:0010181,GO:0016020,GO:0016021,GO:0016491,GO:0016709,GO:0032770,GO:0043231,GO:0050660,GO:0050661,GO:0055114,GO:0090346" "NADPH-hemoprotein reductase activity|protein binding|endoplasmic reticulum membrane|cytosol|xenobiotic metabolic process|response to hormone|FMN binding|membrane|integral component of membrane|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|positive regulation of monooxygenase activity|intracellular membrane-bounded organelle|flavin adenine dinucleotide binding|NADP binding|oxidation-reduction process|cellular organofluorine metabolic process" PORCN 363.8548225 354.781134 372.9285109 1.051150907 0.071969803 0.816815721 1 8.479183637 8.763756237 64840 porcupine O-acyltransferase "GO:0005783,GO:0005789,GO:0006497,GO:0009100,GO:0016020,GO:0016055,GO:0016746,GO:0017147,GO:0018345,GO:0030176,GO:0030258,GO:0032281,GO:0045234,GO:0060070,GO:0061355,GO:0098978,GO:0099072,GO:1990698" "endoplasmic reticulum|endoplasmic reticulum membrane|protein lipidation|glycoprotein metabolic process|membrane|Wnt signaling pathway|transferase activity, transferring acyl groups|Wnt-protein binding|protein palmitoylation|integral component of endoplasmic reticulum membrane|lipid modification|AMPA glutamate receptor complex|protein palmitoleylation|canonical Wnt signaling pathway|Wnt protein secretion|glutamatergic synapse|regulation of postsynaptic membrane neurotransmitter receptor levels|palmitoleoyltransferase activity" hsa04310 Wnt signaling pathway POT1 1098.14852 1123.646993 1072.650047 0.954614797 -0.067009395 0.786521089 1 15.28210368 14.34440315 25913 protection of telomeres 1 "GO:0000781,GO:0000783,GO:0005515,GO:0005654,GO:0007004,GO:0010521,GO:0016233,GO:0017151,GO:0032202,GO:0032210,GO:0032211,GO:0032212,GO:0032508,GO:0042162,GO:0043047,GO:0051096,GO:0051973,GO:0051974,GO:0060383,GO:0061820,GO:0061821,GO:0061849,GO:0070187,GO:0070200,GO:0098505,GO:1905773,GO:1905774,GO:1905776,GO:1990955,GO:2001032" "chromosome, telomeric region|nuclear telomere cap complex|protein binding|nucleoplasm|telomere maintenance via telomerase|telomerase inhibitor activity|telomere capping|DEAD/H-box RNA helicase binding|telomere assembly|regulation of telomere maintenance via telomerase|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance via telomerase|DNA duplex unwinding|telomeric DNA binding|single-stranded telomeric DNA binding|positive regulation of helicase activity|positive regulation of telomerase activity|negative regulation of telomerase activity|positive regulation of DNA strand elongation|telomeric D-loop disassembly|telomeric D-loop binding|telomeric G-quadruplex DNA binding|shelterin complex|establishment of protein localization to telomere|G-rich strand telomeric DNA binding|8-hydroxy-2'-deoxyguanosine DNA binding|regulation of DNA helicase activity|positive regulation of DNA helicase activity|G-rich single-stranded DNA binding|regulation of double-strand break repair via nonhomologous end joining" POU2F1 556.1835501 609.6825352 502.684565 0.824502156 -0.278404828 0.297686039 1 2.197449609 1.781483889 5451 POU class 2 homeobox 1 "GO:0000785,GO:0000978,GO:0000979,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005783,GO:0006357,GO:0019221,GO:0042795,GO:0043231,GO:0043565,GO:0045892,GO:0045944,GO:0090575" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|endoplasmic reticulum|regulation of transcription by RNA polymerase II|cytokine-mediated signaling pathway|snRNA transcription by RNA polymerase II|intracellular membrane-bounded organelle|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulator complex" hsa05168 Herpes simplex virus 1 infection POU POU2F2 1038.552435 1035.211813 1041.893056 1.006453987 0.009281216 0.974180591 1 5.828394539 5.76785117 5452 POU class 2 homeobox 2 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006959,GO:0032755,GO:0042795,GO:0043231,GO:0043565,GO:0045944,GO:0098586,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|humoral immune response|positive regulation of interleukin-6 production|snRNA transcription by RNA polymerase II|intracellular membrane-bounded organelle|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|cellular response to virus|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection POU POU2F3 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.030609138 0.009268058 25833 POU class 2 homeobox 3 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0006357,GO:0008544,GO:0016604,GO:0043565,GO:0043922,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|epidermis development|nuclear body|sequence-specific DNA binding|negative regulation by host of viral transcription|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection POU3F2 27.33822453 36.41448589 18.26196316 0.501502705 -0.995670613 0.188018719 1 0.397824808 0.196171684 5454 POU class 3 homeobox 2 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005654,GO:0005667,GO:0006357,GO:0007399,GO:0008284,GO:0008544,GO:0010629,GO:0014002,GO:0021799,GO:0021869,GO:0021979,GO:0021985,GO:0022011,GO:0030182,GO:0040018,GO:0042802,GO:0045595,GO:0045944,GO:0048663,GO:0048665,GO:0048666,GO:0050770,GO:0071310,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|nervous system development|positive regulation of cell population proliferation|epidermis development|negative regulation of gene expression|astrocyte development|cerebral cortex radially oriented cell migration|forebrain ventricular zone progenitor cell division|hypothalamus cell differentiation|neurohypophysis development|myelination in peripheral nervous system|neuron differentiation|positive regulation of multicellular organism growth|identical protein binding|regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|neuron fate commitment|neuron fate specification|neuron development|regulation of axonogenesis|cellular response to organic substance|sequence-specific double-stranded DNA binding" POU POU4F3 2.601034707 5.202069413 0 0 #NAME? 0.147074026 1 0.107815489 0 5459 POU class 4 homeobox 3 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007601,GO:0007605,GO:0021562,GO:0031290,GO:0042472,GO:0042491,GO:0045944,GO:0048675,GO:0050885,GO:0051402,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|visual perception|sensory perception of sound|vestibulocochlear nerve development|retinal ganglion cell axon guidance|inner ear morphogenesis|inner ear auditory receptor cell differentiation|positive regulation of transcription by RNA polymerase II|axon extension|neuromuscular process controlling balance|neuron apoptotic process|sequence-specific double-stranded DNA binding" POU5F1 8.927806347 7.282897178 10.57271552 1.451718356 0.537761587 0.724794316 1 0.140977453 0.201234855 5460 POU class 5 homeobox 1 "GO:0000122,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0001714,GO:0001824,GO:0003677,GO:0003700,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006355,GO:0006357,GO:0009611,GO:0009653,GO:0009786,GO:0010468,GO:0031625,GO:0035019,GO:0035198,GO:0043565,GO:0045944,GO:0060965,GO:1902894,GO:1990837" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|endodermal cell fate specification|blastocyst development|DNA binding|DNA-binding transcription factor activity|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|response to wounding|anatomical structure morphogenesis|regulation of asymmetric cell division|regulation of gene expression|ubiquitin protein ligase binding|somatic stem cell population maintenance|miRNA binding|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|negative regulation of gene silencing by miRNA|negative regulation of pri-miRNA transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" hsa04550 Signaling pathways regulating pluripotency of stem cells POU POU6F1 263.9247855 279.8713344 247.9782366 0.886043714 -0.174550217 0.601942883 1 1.46433517 1.275753654 5463 POU class 6 homeobox 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0007420,GO:0007507,GO:0007517,GO:0043565,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|brain development|heart development|muscle organ development|sequence-specific DNA binding|sequence-specific double-stranded DNA binding" POU6F2 1.922311912 0 3.844623824 Inf Inf 0.288176591 1 0 0.032362382 11281 POU class 6 homeobox 2 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0007402,GO:0007417,GO:0007601" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|ganglion mother cell fate determination|central nervous system development|visual perception" PPA1 4439.959907 4224.080364 4655.839451 1.102213748 0.140404028 0.557080905 1 174.482512 189.0988586 5464 inorganic pyrophosphatase 1 "GO:0000287,GO:0004427,GO:0005737,GO:0005829,GO:0006418,GO:0006796,GO:0070062,GO:0071344" magnesium ion binding|inorganic diphosphatase activity|cytoplasm|cytosol|tRNA aminoacylation for protein translation|phosphate-containing compound metabolic process|extracellular exosome|diphosphate metabolic process hsa00190 Oxidative phosphorylation PPA2 741.7206338 724.1280623 759.3132052 1.048589669 0.068450237 0.79213856 1 23.21044072 23.93096106 27068 inorganic pyrophosphatase 2 "GO:0000287,GO:0004427,GO:0004722,GO:0005759,GO:0005829,GO:0006418,GO:0006470,GO:0006796,GO:0051881,GO:0071344" magnesium ion binding|inorganic diphosphatase activity|protein serine/threonine phosphatase activity|mitochondrial matrix|cytosol|tRNA aminoacylation for protein translation|protein dephosphorylation|phosphate-containing compound metabolic process|regulation of mitochondrial membrane potential|diphosphate metabolic process hsa00190 Oxidative phosphorylation PPAN 41.26995547 48.89945248 33.64045846 0.687951639 -0.539620945 0.410991008 1 1.06910033 0.723181906 56342 peter pan homolog "GO:0000027,GO:0003723,GO:0005634,GO:0005730,GO:0019843,GO:0030687" "ribosomal large subunit assembly|RNA binding|nucleus|nucleolus|rRNA binding|preribosome, large subunit precursor" PPARA 377.2562856 391.1956199 363.3169514 0.928734712 -0.106661537 0.723374731 1 4.72125537 4.311420161 5465 peroxisome proliferator activated receptor alpha "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001103,GO:0001223,GO:0001227,GO:0001228,GO:0001666,GO:0003677,GO:0003700,GO:0003707,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0006367,GO:0006631,GO:0007507,GO:0008134,GO:0008144,GO:0008270,GO:0008289,GO:0008544,GO:0009267,GO:0009755,GO:0010565,GO:0010745,GO:0010876,GO:0010887,GO:0010891,GO:0019216,GO:0019217,GO:0019902,GO:0019904,GO:0030154,GO:0030512,GO:0030522,GO:0031624,GO:0032000,GO:0032091,GO:0032099,GO:0032868,GO:0032922,GO:0033993,GO:0035095,GO:0042060,GO:0042157,GO:0042752,GO:0043401,GO:0043565,GO:0044877,GO:0045070,GO:0045471,GO:0045722,GO:0045776,GO:0045820,GO:0045893,GO:0045923,GO:0045944,GO:0046321,GO:0046889,GO:0050728,GO:0051525,GO:0051898,GO:0061052,GO:0070166,GO:0097371,GO:1900016,GO:1901215,GO:1902894,GO:1903038,GO:1903427,GO:1903944,GO:2000191,GO:2000272,GO:2001171" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II repressing transcription factor binding|transcription coactivator binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|response to hypoxia|DNA binding|DNA-binding transcription factor activity|steroid hormone receptor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|fatty acid metabolic process|heart development|transcription factor binding|drug binding|zinc ion binding|lipid binding|epidermis development|cellular response to starvation|hormone-mediated signaling pathway|regulation of cellular ketone metabolic process|negative regulation of macrophage derived foam cell differentiation|lipid localization|negative regulation of cholesterol storage|negative regulation of sequestering of triglyceride|regulation of lipid metabolic process|regulation of fatty acid metabolic process|phosphatase binding|protein domain specific binding|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway|intracellular receptor signaling pathway|ubiquitin conjugating enzyme binding|positive regulation of fatty acid beta-oxidation|negative regulation of protein binding|negative regulation of appetite|response to insulin|circadian regulation of gene expression|response to lipid|behavioral response to nicotine|wound healing|lipoprotein metabolic process|regulation of circadian rhythm|steroid hormone mediated signaling pathway|sequence-specific DNA binding|protein-containing complex binding|positive regulation of viral genome replication|response to ethanol|positive regulation of gluconeogenesis|negative regulation of blood pressure|negative regulation of glycolytic process|positive regulation of transcription, DNA-templated|positive regulation of fatty acid metabolic process|positive regulation of transcription by RNA polymerase II|positive regulation of fatty acid oxidation|positive regulation of lipid biosynthetic process|negative regulation of inflammatory response|NFAT protein binding|negative regulation of protein kinase B signaling|negative regulation of cell growth involved in cardiac muscle cell development|enamel mineralization|MDM2/MDM4 family protein binding|negative regulation of cytokine production involved in inflammatory response|negative regulation of neuron death|negative regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of leukocyte cell-cell adhesion|negative regulation of reactive oxygen species biosynthetic process|negative regulation of hepatocyte apoptotic process|regulation of fatty acid transport|negative regulation of signaling receptor activity|positive regulation of ATP biosynthetic process" "hsa03320,hsa04024,hsa04920,hsa04922,hsa04931,hsa04932,hsa05160" PPAR signaling pathway|cAMP signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Hepatitis C PPARD 975.2708559 850.0181421 1100.52357 1.294705978 0.372624505 0.130495288 1 10.31466712 13.13099235 5467 peroxisome proliferator activated receptor delta "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001103,GO:0001223,GO:0001227,GO:0003677,GO:0003700,GO:0003707,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0006006,GO:0006029,GO:0006091,GO:0006357,GO:0006367,GO:0006629,GO:0006631,GO:0006635,GO:0006776,GO:0006915,GO:0007507,GO:0007566,GO:0008134,GO:0008144,GO:0008203,GO:0008270,GO:0008283,GO:0008289,GO:0008366,GO:0008654,GO:0009062,GO:0009749,GO:0009755,GO:0010887,GO:0014068,GO:0014823,GO:0014842,GO:0014912,GO:0015908,GO:0019216,GO:0030154,GO:0030308,GO:0030522,GO:0031589,GO:0032966,GO:0033189,GO:0033993,GO:0035774,GO:0042060,GO:0043066,GO:0043401,GO:0043415,GO:0043616,GO:0045600,GO:0045662,GO:0045684,GO:0045892,GO:0045893,GO:0045923,GO:0045944,GO:0046321,GO:0046697,GO:0048662,GO:0050680,GO:0050728,GO:0051059,GO:0051546,GO:0060612,GO:0070539,GO:0071222,GO:0071456,GO:0097190,GO:1902894,GO:1904659,GO:1990837,GO:2000288" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II repressing transcription factor binding|transcription coactivator binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|steroid hormone receptor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|glucose metabolic process|proteoglycan metabolic process|generation of precursor metabolites and energy|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|lipid metabolic process|fatty acid metabolic process|fatty acid beta-oxidation|vitamin A metabolic process|apoptotic process|heart development|embryo implantation|transcription factor binding|drug binding|cholesterol metabolic process|zinc ion binding|cell population proliferation|lipid binding|axon ensheathment|phospholipid biosynthetic process|fatty acid catabolic process|response to glucose|hormone-mediated signaling pathway|negative regulation of cholesterol storage|positive regulation of phosphatidylinositol 3-kinase signaling|response to activity|regulation of skeletal muscle satellite cell proliferation|negative regulation of smooth muscle cell migration|fatty acid transport|regulation of lipid metabolic process|cell differentiation|negative regulation of cell growth|intracellular receptor signaling pathway|cell-substrate adhesion|negative regulation of collagen biosynthetic process|response to vitamin A|response to lipid|positive regulation of insulin secretion involved in cellular response to glucose stimulus|wound healing|negative regulation of apoptotic process|steroid hormone mediated signaling pathway|positive regulation of skeletal muscle tissue regeneration|keratinocyte proliferation|positive regulation of fat cell differentiation|negative regulation of myoblast differentiation|positive regulation of epidermis development|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of fatty acid metabolic process|positive regulation of transcription by RNA polymerase II|positive regulation of fatty acid oxidation|decidualization|negative regulation of smooth muscle cell proliferation|negative regulation of epithelial cell proliferation|negative regulation of inflammatory response|NF-kappaB binding|keratinocyte migration|adipose tissue development|linoleic acid binding|cellular response to lipopolysaccharide|cellular response to hypoxia|apoptotic signaling pathway|negative regulation of pri-miRNA transcription by RNA polymerase II|glucose transmembrane transport|sequence-specific double-stranded DNA binding|positive regulation of myoblast proliferation" "hsa03320,hsa04310,hsa05200,hsa05221" PPAR signaling pathway|Wnt signaling pathway|Pathways in cancer|Acute myeloid leukemia PPARG 1188.566377 1150.697754 1226.435 1.06581854 0.091961834 0.706691483 1 8.681173911 9.097727104 5468 peroxisome proliferator activated receptor gamma "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001103,GO:0001227,GO:0001890,GO:0002674,GO:0003677,GO:0003682,GO:0003690,GO:0003700,GO:0004879,GO:0004955,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006367,GO:0006629,GO:0006631,GO:0006919,GO:0007165,GO:0007186,GO:0007507,GO:0007584,GO:0008022,GO:0008134,GO:0008217,GO:0008270,GO:0009409,GO:0009612,GO:0009755,GO:0010742,GO:0010745,GO:0010887,GO:0010891,GO:0015909,GO:0016525,GO:0019216,GO:0019395,GO:0019899,GO:0019903,GO:0030154,GO:0030224,GO:0030308,GO:0030331,GO:0030514,GO:0030855,GO:0031000,GO:0031100,GO:0032869,GO:0032966,GO:0033189,GO:0033613,GO:0033993,GO:0035357,GO:0035902,GO:0042277,GO:0042493,GO:0042593,GO:0042594,GO:0042752,GO:0042802,GO:0042953,GO:0043231,GO:0043235,GO:0043388,GO:0043537,GO:0043565,GO:0043621,GO:0043627,GO:0045087,GO:0045165,GO:0045600,GO:0045668,GO:0045892,GO:0045893,GO:0045923,GO:0045944,GO:0046321,GO:0046965,GO:0048384,GO:0048469,GO:0048471,GO:0048511,GO:0048662,GO:0048714,GO:0050544,GO:0050692,GO:0050693,GO:0050728,GO:0050872,GO:0051091,GO:0051393,GO:0051974,GO:0055088,GO:0060100,GO:0060336,GO:0060694,GO:0060965,GO:0070888,GO:0071300,GO:0071306,GO:0071380,GO:0071404,GO:0071455,GO:0090575,GO:1901558,GO:1902895,GO:1904706,GO:1905461,GO:1905563,GO:1905599,GO:2000230,GO:2000272" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II repressing transcription factor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|placenta development|negative regulation of acute inflammatory response|DNA binding|chromatin binding|double-stranded DNA binding|DNA-binding transcription factor activity|nuclear receptor activity|prostaglandin receptor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|lipid metabolic process|fatty acid metabolic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|G protein-coupled receptor signaling pathway|heart development|response to nutrient|protein C-terminus binding|transcription factor binding|regulation of blood pressure|zinc ion binding|response to cold|response to mechanical stimulus|hormone-mediated signaling pathway|macrophage derived foam cell differentiation|negative regulation of macrophage derived foam cell differentiation|negative regulation of cholesterol storage|negative regulation of sequestering of triglyceride|long-chain fatty acid transport|negative regulation of angiogenesis|regulation of lipid metabolic process|fatty acid oxidation|enzyme binding|protein phosphatase binding|cell differentiation|monocyte differentiation|negative regulation of cell growth|estrogen receptor binding|negative regulation of BMP signaling pathway|epithelial cell differentiation|response to caffeine|animal organ regeneration|cellular response to insulin stimulus|negative regulation of collagen biosynthetic process|response to vitamin A|activating transcription factor binding|response to lipid|peroxisome proliferator activated receptor signaling pathway|response to immobilization stress|peptide binding|response to drug|glucose homeostasis|response to starvation|regulation of circadian rhythm|identical protein binding|lipoprotein transport|intracellular membrane-bounded organelle|receptor complex|positive regulation of DNA binding|negative regulation of blood vessel endothelial cell migration|sequence-specific DNA binding|protein self-association|response to estrogen|innate immune response|cell fate commitment|positive regulation of fat cell differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of fatty acid metabolic process|positive regulation of transcription by RNA polymerase II|positive regulation of fatty acid oxidation|retinoid X receptor binding|retinoic acid receptor signaling pathway|cell maturation|perinuclear region of cytoplasm|rhythmic process|negative regulation of smooth muscle cell proliferation|positive regulation of oligodendrocyte differentiation|arachidonic acid binding|DNA binding domain binding|LBD domain binding|negative regulation of inflammatory response|white fat cell differentiation|positive regulation of DNA-binding transcription factor activity|alpha-actinin binding|negative regulation of telomerase activity|lipid homeostasis|positive regulation of phagocytosis, engulfment|negative regulation of interferon-gamma-mediated signaling pathway|regulation of cholesterol transporter activity|negative regulation of gene silencing by miRNA|E-box binding|cellular response to retinoic acid|cellular response to vitamin E|cellular response to prostaglandin E stimulus|cellular response to low-density lipoprotein particle stimulus|cellular response to hyperoxia|RNA polymerase II transcription regulator complex|response to metformin|positive regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of vascular associated smooth muscle cell proliferation|positive regulation of vascular associated smooth muscle cell apoptotic process|negative regulation of vascular endothelial cell proliferation|positive regulation of low-density lipoprotein receptor activity|negative regulation of pancreatic stellate cell proliferation|negative regulation of signaling receptor activity" "hsa03320,hsa04152,hsa04211,hsa04380,hsa04714,hsa05016,hsa05200,hsa05202,hsa05216" PPAR signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Osteoclast differentiation|Thermogenesis|Huntington disease|Pathways in cancer|Transcriptional misregulation in cancer|Thyroid cancer Cnucl_rcpt PPARGC1A 35.22561699 41.61655531 28.83467868 0.692865579 -0.529352609 0.450700514 1 0.200017928 0.136266496 10891 PPARG coactivator 1 alpha "GO:0000302,GO:0000422,GO:0000785,GO:0001659,GO:0001678,GO:0001933,GO:0002021,GO:0002931,GO:0003677,GO:0003712,GO:0003713,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006012,GO:0006094,GO:0006355,GO:0006367,GO:0006397,GO:0007005,GO:0007568,GO:0007586,GO:0007623,GO:0008134,GO:0008209,GO:0008380,GO:0009409,GO:0010628,GO:0010822,GO:0014732,GO:0014850,GO:0014878,GO:0014912,GO:0016605,GO:0016922,GO:0019395,GO:0021549,GO:0022626,GO:0022904,GO:0030331,GO:0030374,GO:0030900,GO:0031490,GO:0031625,GO:0032922,GO:0034599,GO:0035066,GO:0035865,GO:0042493,GO:0042594,GO:0042752,GO:0042975,GO:0043014,GO:0043025,GO:0043201,GO:0043231,GO:0043524,GO:0043565,GO:0045333,GO:0045722,GO:0045820,GO:0045893,GO:0045944,GO:0046321,GO:0048661,GO:0048662,GO:0050821,GO:0050873,GO:0051091,GO:0051552,GO:0060612,GO:0065003,GO:0071222,GO:0071250,GO:0071313,GO:0071332,GO:0071333,GO:0071354,GO:0071356,GO:0071372,GO:0071392,GO:0071456,GO:0071560,GO:0071871,GO:0071873,GO:0090258,GO:0097009,GO:0097067,GO:0097440,GO:0120162,GO:1901215,GO:1901558,GO:1901857,GO:1901860,GO:1901863,GO:1904635,GO:1904637,GO:1904639,GO:1904640,GO:1990841,GO:1990843,GO:1990844,GO:1990845,GO:2000184,GO:2000272,GO:2000310,GO:2001171" "response to reactive oxygen species|autophagy of mitochondrion|chromatin|temperature homeostasis|cellular glucose homeostasis|negative regulation of protein phosphorylation|response to dietary excess|response to ischemia|DNA binding|transcription coregulator activity|transcription coactivator activity|RNA binding|protein binding|nucleus|nucleoplasm|galactose metabolic process|gluconeogenesis|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|mRNA processing|mitochondrion organization|aging|digestion|circadian rhythm|transcription factor binding|androgen metabolic process|RNA splicing|response to cold|positive regulation of gene expression|positive regulation of mitochondrion organization|skeletal muscle atrophy|response to muscle activity|response to electrical stimulus involved in regulation of muscle adaptation|negative regulation of smooth muscle cell migration|PML body|nuclear receptor binding|fatty acid oxidation|cerebellum development|cytosolic ribosome|respiratory electron transport chain|estrogen receptor binding|nuclear receptor coactivator activity|forebrain development|chromatin DNA binding|ubiquitin protein ligase binding|circadian regulation of gene expression|cellular response to oxidative stress|positive regulation of histone acetylation|cellular response to potassium ion|response to drug|response to starvation|regulation of circadian rhythm|peroxisome proliferator activated receptor binding|alpha-tubulin binding|neuronal cell body|response to leucine|intracellular membrane-bounded organelle|negative regulation of neuron apoptotic process|sequence-specific DNA binding|cellular respiration|positive regulation of gluconeogenesis|negative regulation of glycolytic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of fatty acid oxidation|positive regulation of smooth muscle cell proliferation|negative regulation of smooth muscle cell proliferation|protein stabilization|brown fat cell differentiation|positive regulation of DNA-binding transcription factor activity|flavone metabolic process|adipose tissue development|protein-containing complex assembly|cellular response to lipopolysaccharide|cellular response to nitrite|cellular response to caffeine|cellular response to fructose stimulus|cellular response to glucose stimulus|cellular response to interleukin-6|cellular response to tumor necrosis factor|cellular response to follicle-stimulating hormone stimulus|cellular response to estradiol stimulus|cellular response to hypoxia|cellular response to transforming growth factor beta stimulus|response to epinephrine|response to norepinephrine|negative regulation of mitochondrial fission|energy homeostasis|cellular response to thyroid hormone stimulus|apical dendrite|positive regulation of cold-induced thermogenesis|negative regulation of neuron death|response to metformin|positive regulation of cellular respiration|positive regulation of mitochondrial DNA metabolic process|positive regulation of muscle tissue development|positive regulation of glomerular visceral epithelial cell apoptotic process|cellular response to ionomycin|cellular response to resveratrol|response to methionine|promoter-specific chromatin binding|subsarcolemmal mitochondrion|interfibrillar mitochondrion|adaptive thermogenesis|positive regulation of progesterone biosynthetic process|negative regulation of signaling receptor activity|regulation of NMDA receptor activity|positive regulation of ATP biosynthetic process" "hsa04152,hsa04211,hsa04371,hsa04714,hsa04910,hsa04920,hsa04922,hsa04931,hsa05016" AMPK signaling pathway|Longevity regulating pathway|Apelin signaling pathway|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance|Huntington disease other PPARGC1B 113.7573578 147.7387713 79.77594435 0.539979747 -0.889022798 0.046885907 1 0.601735991 0.319488064 133522 PPARG coactivator 1 beta "GO:0001503,GO:0003712,GO:0003723,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006355,GO:0006390,GO:0007015,GO:0008134,GO:0010694,GO:0016592,GO:0030331,GO:0030374,GO:0030520,GO:0034614,GO:0042327,GO:0045672,GO:0045780,GO:0045892,GO:0045944,GO:0050682,GO:0051091,GO:0051384,GO:0051591,GO:0060346,GO:0120162" "ossification|transcription coregulator activity|RNA binding|nucleus|nucleoplasm|mitochondrion|cytosol|regulation of transcription, DNA-templated|mitochondrial transcription|actin filament organization|transcription factor binding|positive regulation of alkaline phosphatase activity|mediator complex|estrogen receptor binding|nuclear receptor coactivator activity|intracellular estrogen receptor signaling pathway|cellular response to reactive oxygen species|positive regulation of phosphorylation|positive regulation of osteoclast differentiation|positive regulation of bone resorption|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|AF-2 domain binding|positive regulation of DNA-binding transcription factor activity|response to glucocorticoid|response to cAMP|bone trabecula formation|positive regulation of cold-induced thermogenesis" hsa04931 Insulin resistance PPAT 774.9295897 801.1186896 748.7404897 0.934618677 -0.097550227 0.702933453 1 11.61168715 10.67089779 5471 phosphoribosyl pyrophosphate amidotransferase "GO:0000082,GO:0001822,GO:0004044,GO:0005829,GO:0006164,GO:0006189,GO:0006543,GO:0007595,GO:0009113,GO:0009116,GO:0009168,GO:0031100,GO:0032869,GO:0035690,GO:0042802,GO:0046872,GO:0051539,GO:0060135" "G1/S transition of mitotic cell cycle|kidney development|amidophosphoribosyltransferase activity|cytosol|purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process|glutamine catabolic process|lactation|purine nucleobase biosynthetic process|nucleoside metabolic process|purine ribonucleoside monophosphate biosynthetic process|animal organ regeneration|cellular response to insulin stimulus|cellular response to drug|identical protein binding|metal ion binding|4 iron, 4 sulfur cluster binding|maternal process involved in female pregnancy" "hsa00230,hsa00250" "Purine metabolism|Alanine, aspartate and glutamate metabolism" PPCDC 196.1538442 203.921121 188.3865674 0.923820772 -0.11431511 0.766120767 1 2.018341142 1.833384159 60490 phosphopantothenoylcysteine decarboxylase "GO:0004633,GO:0005515,GO:0005829,GO:0010181,GO:0015937,GO:0042802,GO:0071513" phosphopantothenoylcysteine decarboxylase activity|protein binding|cytosol|FMN binding|coenzyme A biosynthetic process|identical protein binding|phosphopantothenoylcysteine decarboxylase complex hsa00770 Pantothenate and CoA biosynthesis PPCS 452.3598139 457.7821084 446.9375195 0.976310588 -0.034587917 0.90979536 1 10.93598467 10.49825387 79717 phosphopantothenoylcysteine synthetase "GO:0003015,GO:0004632,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006085,GO:0015937,GO:0042802,GO:0042803" heart process|phosphopantothenate--cysteine ligase activity|ATP binding|nucleus|cytoplasm|cytosol|acetyl-CoA biosynthetic process|coenzyme A biosynthetic process|identical protein binding|protein homodimerization activity hsa00770 Pantothenate and CoA biosynthesis PPDPF 2102.382388 2052.73659 2152.028185 1.048370354 0.068148462 0.774764872 1 132.4676893 136.5513099 79144 pancreatic progenitor cell differentiation and proliferation factor "GO:0007275,GO:0030154" multicellular organism development|cell differentiation PPFIA1 1466.996592 1609.520276 1324.472907 0.822899175 -0.281212419 0.239212123 1 13.24959725 10.72063432 8500 PTPRF interacting protein alpha 1 "GO:0005515,GO:0005737,GO:0005829,GO:0005925,GO:0007160,GO:0007165,GO:0007269,GO:0014047,GO:0048786,GO:0050808,GO:0051497,GO:1903077" protein binding|cytoplasm|cytosol|focal adhesion|cell-matrix adhesion|signal transduction|neurotransmitter secretion|glutamate secretion|presynaptic active zone|synapse organization|negative regulation of stress fiber assembly|negative regulation of protein localization to plasma membrane PPFIA3 168.860279 156.0620824 181.6584757 1.164014172 0.219108624 0.580186839 1 1.75786123 2.011935411 8541 PTPRF interacting protein alpha 3 "GO:0001669,GO:0005515,GO:0005829,GO:0007269,GO:0014047,GO:0016081,GO:0048172,GO:0048786,GO:0050808,GO:0098831,GO:0098875,GO:0098978" acrosomal vesicle|protein binding|cytosol|neurotransmitter secretion|glutamate secretion|synaptic vesicle docking|regulation of short-term neuronal synaptic plasticity|presynaptic active zone|synapse organization|presynaptic active zone cytoplasmic component|epididymosome|glutamatergic synapse PPFIA4 67.97914701 56.18234966 79.77594435 1.419946742 0.505836819 0.351350748 1 0.460717385 0.643247097 8497 PTPRF interacting protein alpha 4 "GO:0005515,GO:0005829,GO:0007269,GO:0009986,GO:0014047,GO:0045202,GO:0048786,GO:0050808" protein binding|cytosol|neurotransmitter secretion|cell surface|glutamate secretion|synapse|presynaptic active zone|synapse organization PPFIBP1 2369.056049 2467.86173 2270.250368 0.91992608 -0.120410155 0.611263508 1 21.72636832 19.65220329 8496 PPFIA binding protein 1 "GO:0005515,GO:0005829,GO:0005886,GO:0005925,GO:0007155,GO:0007528,GO:0045296,GO:0048786,GO:0050808" protein binding|cytosol|plasma membrane|focal adhesion|cell adhesion|neuromuscular junction development|cadherin binding|presynaptic active zone|synapse organization PPFIBP2 27.62065769 31.21241648 24.0288989 0.769850643 -0.377349516 0.642993258 1 0.201688982 0.152672153 8495 PPFIA binding protein 2 "GO:0003674,GO:0005515,GO:0005615,GO:0005829,GO:0007528,GO:0042802,GO:0048786,GO:0050808" molecular_function|protein binding|extracellular space|cytosol|neuromuscular junction development|identical protein binding|presynaptic active zone|synapse organization PPHLN1 1239.929084 1098.67706 1381.181109 1.257131107 0.330135117 0.171713591 1 12.04238558 14.88552924 51535 periphilin 1 "GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005794,GO:0005829,GO:0031424,GO:0045814,GO:0045892,GO:0090309,GO:0097355" "RNA binding|protein binding|nucleoplasm|chromosome|Golgi apparatus|cytosol|keratinization|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|positive regulation of DNA methylation-dependent heterochromatin assembly|protein localization to heterochromatin" PPIA 28161.02298 22675.82057 33646.2254 1.483793069 0.569289906 0.049515781 1 959.6882375 1400.150399 5478 peptidylprolyl isomerase A "GO:0000187,GO:0000413,GO:0001933,GO:0001934,GO:0003723,GO:0003755,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005925,GO:0006278,GO:0006457,GO:0006469,GO:0006915,GO:0016018,GO:0016020,GO:0019058,GO:0019061,GO:0019064,GO:0019068,GO:0019076,GO:0030168,GO:0030593,GO:0030595,GO:0031982,GO:0032148,GO:0032873,GO:0032991,GO:0034389,GO:0034599,GO:0034774,GO:0035307,GO:0035722,GO:0042118,GO:0043231,GO:0043312,GO:0045069,GO:0045070,GO:0046790,GO:0050714,GO:0050900,GO:0051082,GO:0051092,GO:0060352,GO:0061944,GO:0070062,GO:0070527,GO:0075713,GO:1902176,GO:1903901,GO:1904399,GO:1904813,GO:2001233" activation of MAPK activity|protein peptidyl-prolyl isomerization|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|RNA binding|peptidyl-prolyl cis-trans isomerase activity|integrin binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|cytosol|focal adhesion|RNA-dependent DNA biosynthetic process|protein folding|negative regulation of protein kinase activity|apoptotic process|cyclosporin A binding|membrane|viral life cycle|uncoating of virus|fusion of virus membrane with host plasma membrane|virion assembly|viral release from host cell|platelet activation|neutrophil chemotaxis|leukocyte chemotaxis|vesicle|activation of protein kinase B activity|negative regulation of stress-activated MAPK cascade|protein-containing complex|lipid droplet organization|cellular response to oxidative stress|secretory granule lumen|positive regulation of protein dephosphorylation|interleukin-12-mediated signaling pathway|endothelial cell activation|intracellular membrane-bounded organelle|neutrophil degranulation|regulation of viral genome replication|positive regulation of viral genome replication|virion binding|positive regulation of protein secretion|leukocyte migration|unfolded protein binding|positive regulation of NF-kappaB transcription factor activity|cell adhesion molecule production|negative regulation of protein K48-linked ubiquitination|extracellular exosome|platelet aggregation|establishment of integrated proviral latency|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|negative regulation of viral life cycle|heparan sulfate binding|ficolin-1-rich granule lumen|regulation of apoptotic signaling pathway hsa04217 Necroptosis PPIB 5527.180894 5035.603192 6018.758596 1.195240841 0.257301351 0.286060126 1 300.9416431 353.6786882 5479 peptidylprolyl isomerase B "GO:0000413,GO:0003723,GO:0003755,GO:0005515,GO:0005518,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005788,GO:0005925,GO:0006457,GO:0016018,GO:0016020,GO:0030593,GO:0032991,GO:0040018,GO:0042470,GO:0043231,GO:0044794,GO:0044829,GO:0048471,GO:0050821,GO:0051082,GO:0060348,GO:0061077,GO:0070062,GO:0070063,GO:1901873" protein peptidyl-prolyl isomerization|RNA binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|collagen binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|focal adhesion|protein folding|cyclosporin A binding|membrane|neutrophil chemotaxis|protein-containing complex|positive regulation of multicellular organism growth|melanosome|intracellular membrane-bounded organelle|positive regulation by host of viral process|positive regulation by host of viral genome replication|perinuclear region of cytoplasm|protein stabilization|unfolded protein binding|bone development|chaperone-mediated protein folding|extracellular exosome|RNA polymerase binding|regulation of post-translational protein modification PPIC 436.1491104 435.9334168 436.364804 1.000989571 0.001426944 1 1 17.05642613 16.78760605 5480 peptidylprolyl isomerase C "GO:0000413,GO:0003755,GO:0005515,GO:0005737,GO:0006457,GO:0016018,GO:0043231,GO:0070062" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|protein binding|cytoplasm|protein folding|cyclosporin A binding|intracellular membrane-bounded organelle|extracellular exosome PPID 638.6051885 603.4400519 673.7703252 1.116548898 0.159046434 0.543524483 1 17.59808005 19.32031553 5481 peptidylprolyl isomerase D "GO:0000122,GO:0000413,GO:0003755,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006457,GO:0006915,GO:0008134,GO:0015031,GO:0016018,GO:0019076,GO:0030331,GO:0030544,GO:0031072,GO:0034389,GO:0043065,GO:0045070,GO:0050714,GO:0051879,GO:0061077,GO:0065003,GO:0071492" negative regulation of transcription by RNA polymerase II|protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|protein folding|apoptotic process|transcription factor binding|protein transport|cyclosporin A binding|viral release from host cell|estrogen receptor binding|Hsp70 protein binding|heat shock protein binding|lipid droplet organization|positive regulation of apoptotic process|positive regulation of viral genome replication|positive regulation of protein secretion|Hsp90 protein binding|chaperone-mediated protein folding|protein-containing complex assembly|cellular response to UV-A "hsa04217,hsa04218,hsa05010,hsa05022,hsa05131" Necroptosis|Cellular senescence|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Shigellosis PPIE 580.544572 580.5509465 580.5381974 0.99997804 -3.17E-05 1 1 17.36711716 17.07612697 10450 peptidylprolyl isomerase E "GO:0000398,GO:0000413,GO:0003723,GO:0003729,GO:0003755,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006283,GO:0006355,GO:0006457,GO:0008143,GO:0016018,GO:0016607,GO:0034774,GO:0043312,GO:0045070,GO:0071007,GO:0071013,GO:1904813" "mRNA splicing, via spliceosome|protein peptidyl-prolyl isomerization|RNA binding|mRNA binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|transcription-coupled nucleotide-excision repair|regulation of transcription, DNA-templated|protein folding|poly(A) binding|cyclosporin A binding|nuclear speck|secretory granule lumen|neutrophil degranulation|positive regulation of viral genome replication|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|ficolin-1-rich granule lumen" hsa03040 Spliceosome PPIF 6744.58122 5492.344886 7996.817554 1.455993336 0.542003752 0.026539636 0.870334587 129.8123791 185.8432002 10105 peptidylprolyl isomerase F "GO:0000413,GO:0002931,GO:0003755,GO:0005515,GO:0005737,GO:0005739,GO:0005753,GO:0005757,GO:0005759,GO:0006457,GO:0008637,GO:0010849,GO:0010939,GO:0016018,GO:0016020,GO:0032780,GO:0043066,GO:0043231,GO:0046902,GO:0070266,GO:0070301,GO:0071243,GO:0071277,GO:0090200,GO:0090201,GO:0090324,GO:1902445,GO:1902686,GO:2000276,GO:2001243" "protein peptidyl-prolyl isomerization|response to ischemia|peptidyl-prolyl cis-trans isomerase activity|protein binding|cytoplasm|mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial permeability transition pore complex|mitochondrial matrix|protein folding|apoptotic mitochondrial changes|regulation of proton-transporting ATPase activity, rotational mechanism|regulation of necrotic cell death|cyclosporin A binding|membrane|negative regulation of ATPase activity|negative regulation of apoptotic process|intracellular membrane-bounded organelle|regulation of mitochondrial membrane permeability|necroptotic process|cellular response to hydrogen peroxide|cellular response to arsenic-containing substance|cellular response to calcium ion|positive regulation of release of cytochrome c from mitochondria|negative regulation of release of cytochrome c from mitochondria|negative regulation of oxidative phosphorylation|regulation of mitochondrial membrane permeability involved in programmed necrotic cell death|mitochondrial outer membrane permeabilization involved in programmed cell death|negative regulation of oxidative phosphorylation uncoupler activity|negative regulation of intrinsic apoptotic signaling pathway" "hsa04020,hsa04022,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05145" Calcium signaling pathway|cGMP-PKG signaling pathway|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Toxoplasmosis PPIG 1224.178223 1227.688382 1220.668064 0.994281678 -0.008273473 0.976473145 1 9.760088265 9.541889006 9360 peptidylprolyl isomerase G "GO:0000413,GO:0003723,GO:0003755,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006457,GO:0008380,GO:0016018,GO:0016363,GO:0016607,GO:0043231" protein peptidyl-prolyl isomerization|RNA binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein folding|RNA splicing|cyclosporin A binding|nuclear matrix|nuclear speck|intracellular membrane-bounded organelle PPIH 708.3330404 692.9156458 723.7504349 1.044500062 0.062812578 0.810854433 1 8.662364604 8.896437008 10465 peptidylprolyl isomerase H "GO:0000398,GO:0000413,GO:0003755,GO:0005515,GO:0005654,GO:0005681,GO:0005737,GO:0006457,GO:0016018,GO:0016607,GO:0043021,GO:0043231,GO:0045070,GO:0046540,GO:0065003,GO:0071001" "mRNA splicing, via spliceosome|protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|protein binding|nucleoplasm|spliceosomal complex|cytoplasm|protein folding|cyclosporin A binding|nuclear speck|ribonucleoprotein complex binding|intracellular membrane-bounded organelle|positive regulation of viral genome replication|U4/U6 x U5 tri-snRNP complex|protein-containing complex assembly|U4/U6 snRNP" hsa03040 Spliceosome PPIL1 587.5500664 587.8338437 587.2662891 0.999034498 -0.001393597 1 1 20.69367536 20.32774928 51645 peptidylprolyl isomerase like 1 "GO:0000398,GO:0000413,GO:0003755,GO:0005515,GO:0005634,GO:0005654,GO:0006457,GO:0016018,GO:0071007,GO:0071013,GO:0097718" "mRNA splicing, via spliceosome|protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|protein binding|nucleus|nucleoplasm|protein folding|cyclosporin A binding|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|disordered domain specific binding" hsa03040 Spliceosome PPIL2 1101.501891 1249.537073 953.4667083 0.763055958 -0.390139235 0.10944372 1 9.870559064 7.405754616 23759 peptidylprolyl isomerase like 2 "GO:0000209,GO:0000413,GO:0003755,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005796,GO:0005886,GO:0006457,GO:0016018,GO:0034450,GO:0050900,GO:0061630,GO:0072659" protein polyubiquitination|protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi lumen|plasma membrane|protein folding|cyclosporin A binding|ubiquitin-ubiquitin ligase activity|leukocyte migration|ubiquitin protein ligase activity|protein localization to plasma membrane hsa04120 Ubiquitin mediated proteolysis PPIL3 520.443371 453.6204528 587.2662891 1.294620393 0.372529135 0.16915048 1 13.61579857 17.33232166 53938 peptidylprolyl isomerase like 3 "GO:0000398,GO:0000413,GO:0003755,GO:0005515,GO:0006457,GO:0071013" "mRNA splicing, via spliceosome|protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|protein binding|protein folding|catalytic step 2 spliceosome" PPIL4 639.8538081 585.7530159 693.9546002 1.184722198 0.244548805 0.347914856 1 12.63053006 14.71327258 85313 peptidylprolyl isomerase like 4 "GO:0000413,GO:0003723,GO:0003755,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:1901407" protein peptidyl-prolyl isomerization|RNA binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of phosphorylation of RNA polymerase II C-terminal domain PPIL6 13.32723566 21.84869154 4.80577978 0.219957327 -2.184704438 0.038276994 0.982059825 0.163057546 0.035265538 285755 peptidylprolyl isomerase like 6 "GO:0000413,GO:0003755,GO:0005515,GO:0005737,GO:0006457,GO:0016018" protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|protein binding|cytoplasm|protein folding|cyclosporin A binding PPIP5K1 362.8936665 354.781134 371.006199 1.045732604 0.064513998 0.836747051 1 3.140490473 3.229158091 9677 diphosphoinositol pentakisphosphate kinase 1 "GO:0000827,GO:0000828,GO:0000829,GO:0000832,GO:0005524,GO:0005829,GO:0005886,GO:0006020,GO:0016310,GO:0032958,GO:0033857,GO:0043647,GO:0052723,GO:0052724,GO:0102092" "inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol heptakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity|ATP binding|cytosol|plasma membrane|inositol metabolic process|phosphorylation|inositol phosphate biosynthetic process|diphosphoinositol-pentakisphosphate kinase activity|inositol phosphate metabolic process|inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|5-diphosphoinositol pentakisphosphate 3-kinase activity" hsa04070 Phosphatidylinositol signaling system PPIP5K2 1163.343579 1131.970304 1194.716853 1.055431268 0.07783263 0.751166904 1 3.715324395 3.855652401 23262 diphosphoinositol pentakisphosphate kinase 2 "GO:0000827,GO:0000828,GO:0000829,GO:0000832,GO:0005524,GO:0005829,GO:0006020,GO:0007605,GO:0016310,GO:0032958,GO:0033857,GO:0043647,GO:0052723,GO:0052724,GO:0102092" "inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol heptakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity|ATP binding|cytosol|inositol metabolic process|sensory perception of sound|phosphorylation|inositol phosphate biosynthetic process|diphosphoinositol-pentakisphosphate kinase activity|inositol phosphate metabolic process|inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|5-diphosphoinositol pentakisphosphate 3-kinase activity" hsa04070 Phosphatidylinositol signaling system PPL 201.593073 321.4878897 81.69825626 0.254125455 -1.976387202 1.59E-07 0.000144969 2.690062372 0.672173981 5493 periplakin "GO:0001533,GO:0005198,GO:0005200,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005882,GO:0005886,GO:0009612,GO:0016020,GO:0030057,GO:0042060,GO:0045104,GO:0045296,GO:0070062,GO:0070268" cornified envelope|structural molecule activity|structural constituent of cytoskeleton|protein binding|cytoplasm|cytosol|cytoskeleton|intermediate filament|plasma membrane|response to mechanical stimulus|membrane|desmosome|wound healing|intermediate filament cytoskeleton organization|cadherin binding|extracellular exosome|cornification PPM1A 1310.770963 1305.719423 1315.822504 1.007737559 0.011119973 0.966635797 1 7.141933564 7.076759389 5494 "protein phosphatase, Mg2+/Mn2+ dependent 1A" "GO:0000122,GO:0000287,GO:0004722,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006470,GO:0006499,GO:0007050,GO:0010991,GO:0016020,GO:0016311,GO:0030145,GO:0030512,GO:0030514,GO:0033192,GO:0035970,GO:0043123,GO:0043124,GO:0045893,GO:0046827,GO:0070412,GO:0071560,GO:0090263,GO:0106306,GO:0106307,GO:1901223" "negative regulation of transcription by RNA polymerase II|magnesium ion binding|protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|protein dephosphorylation|N-terminal protein myristoylation|cell cycle arrest|negative regulation of SMAD protein complex assembly|membrane|dephosphorylation|manganese ion binding|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|calmodulin-dependent protein phosphatase activity|peptidyl-threonine dephosphorylation|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription, DNA-templated|positive regulation of protein export from nucleus|R-SMAD binding|cellular response to transforming growth factor beta stimulus|positive regulation of canonical Wnt signaling pathway|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of NIK/NF-kappaB signaling" hsa04010 MAPK signaling pathway PPM1B 827.2628995 825.0482089 829.47759 1.005368633 0.007724584 0.980860712 1 5.579232962 5.515323688 5495 "protein phosphatase, Mg2+/Mn2+ dependent 1B" "GO:0000287,GO:0004722,GO:0005515,GO:0005634,GO:0005730,GO:0005829,GO:0006470,GO:0006499,GO:0016020,GO:0030145,GO:0032688,GO:0035970,GO:0043124,GO:0050687,GO:0090263,GO:0106306,GO:0106307,GO:1901223" magnesium ion binding|protein serine/threonine phosphatase activity|protein binding|nucleus|nucleolus|cytosol|protein dephosphorylation|N-terminal protein myristoylation|membrane|manganese ion binding|negative regulation of interferon-beta production|peptidyl-threonine dephosphorylation|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of defense response to virus|positive regulation of canonical Wnt signaling pathway|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of NIK/NF-kappaB signaling hsa04010 MAPK signaling pathway PPM1D 319.3938139 373.5085839 265.2790439 0.710235468 -0.493630687 0.109453077 1 4.180676728 2.919578266 8493 "protein phosphatase, Mg2+/Mn2+ dependent 1D" "GO:0000086,GO:0004674,GO:0004722,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006306,GO:0006342,GO:0006367,GO:0006468,GO:0006470,GO:0008285,GO:0009267,GO:0009314,GO:0009617,GO:0030330,GO:0035970,GO:0045814,GO:0046872,GO:0051019,GO:0106306,GO:0106307" "G2/M transition of mitotic cell cycle|protein serine/threonine kinase activity|protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|DNA methylation|chromatin silencing|transcription initiation from RNA polymerase II promoter|protein phosphorylation|protein dephosphorylation|negative regulation of cell population proliferation|cellular response to starvation|response to radiation|response to bacterium|DNA damage response, signal transduction by p53 class mediator|peptidyl-threonine dephosphorylation|negative regulation of gene expression, epigenetic|metal ion binding|mitogen-activated protein kinase binding|protein serine phosphatase activity|protein threonine phosphatase activity" hsa04115 p53 signaling pathway PPM1E 6.004709516 6.242483296 5.766935736 0.923820772 -0.11431511 1 1 0.036934574 0.033549959 22843 "protein phosphatase, Mg2+/Mn2+ dependent 1E" "GO:0004722,GO:0004724,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005739,GO:0006469,GO:0006470,GO:0032991,GO:0035690,GO:0035970,GO:0046872,GO:0051496,GO:0106306,GO:0106307" protein serine/threonine phosphatase activity|magnesium-dependent protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|nucleolus|mitochondrion|negative regulation of protein kinase activity|protein dephosphorylation|protein-containing complex|cellular response to drug|peptidyl-threonine dephosphorylation|metal ion binding|positive regulation of stress fiber assembly|protein serine phosphatase activity|protein threonine phosphatase activity PPM1F 1694.171581 1555.418755 1832.924408 1.178412182 0.236844249 0.318912857 1 13.81195344 16.00381446 9647 "protein phosphatase, Mg2+/Mn2+ dependent 1F" "GO:0004722,GO:0004724,GO:0005515,GO:0005634,GO:0005829,GO:0006469,GO:0006470,GO:0008138,GO:0010628,GO:0010634,GO:0010811,GO:0016576,GO:0030335,GO:0032991,GO:0033137,GO:0033192,GO:0035690,GO:0035970,GO:0043280,GO:0044387,GO:0045892,GO:0045927,GO:0046872,GO:0048471,GO:0050921,GO:0051224,GO:0051496,GO:0051894,GO:0070262,GO:0097193,GO:0106306,GO:0106307,GO:1903827,GO:2000048" "protein serine/threonine phosphatase activity|magnesium-dependent protein serine/threonine phosphatase activity|protein binding|nucleus|cytosol|negative regulation of protein kinase activity|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|positive regulation of gene expression|positive regulation of epithelial cell migration|positive regulation of cell-substrate adhesion|histone dephosphorylation|positive regulation of cell migration|protein-containing complex|negative regulation of peptidyl-serine phosphorylation|calmodulin-dependent protein phosphatase activity|cellular response to drug|peptidyl-threonine dephosphorylation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of protein kinase activity by regulation of protein phosphorylation|negative regulation of transcription, DNA-templated|positive regulation of growth|metal ion binding|perinuclear region of cytoplasm|positive regulation of chemotaxis|negative regulation of protein transport|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|peptidyl-serine dephosphorylation|intrinsic apoptotic signaling pathway|protein serine phosphatase activity|protein threonine phosphatase activity|regulation of cellular protein localization|negative regulation of cell-cell adhesion mediated by cadherin" PPM1G 3152.909029 3187.828136 3117.989921 0.978092227 -0.031957588 0.893967624 1 76.98123469 74.03479165 5496 "protein phosphatase, Mg2+/Mn2+ dependent 1G" "GO:0004722,GO:0004724,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006470,GO:0007050,GO:0016020,GO:0035970,GO:0046872,GO:0106306,GO:0106307" protein serine/threonine phosphatase activity|magnesium-dependent protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|protein dephosphorylation|cell cycle arrest|membrane|peptidyl-threonine dephosphorylation|metal ion binding|protein serine phosphatase activity|protein threonine phosphatase activity PPM1H 51.71875368 58.26317743 45.17432993 0.775349576 -0.36708118 0.549903349 1 0.394443574 0.30071398 57460 "protein phosphatase, Mg2+/Mn2+ dependent 1H" "GO:0004721,GO:0004724,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006470,GO:0042802,GO:0098978,GO:0106306,GO:0106307" phosphoprotein phosphatase activity|magnesium-dependent protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|protein dephosphorylation|identical protein binding|glutamatergic synapse|protein serine phosphatase activity|protein threonine phosphatase activity PPM1J 332.6669437 330.8516147 334.4822727 1.010973675 0.015745431 0.969820228 1 10.30160011 10.24037152 333926 "protein phosphatase, Mg2+/Mn2+ dependent 1J" "GO:0004724,GO:0005515,GO:0006470,GO:0106306,GO:0106307" magnesium-dependent protein serine/threonine phosphatase activity|protein binding|protein dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity PPM1K 356.448008 349.5790646 363.3169514 1.039298368 0.055609892 0.86137886 1 2.089181655 2.134949603 152926 "protein phosphatase, Mg2+/Mn2+ dependent 1K" "GO:0005515,GO:0005739,GO:0005759,GO:0006470,GO:0009083,GO:0046872,GO:0106306,GO:0106307" protein binding|mitochondrion|mitochondrial matrix|protein dephosphorylation|branched-chain amino acid catabolic process|metal ion binding|protein serine phosphatase activity|protein threonine phosphatase activity PPM1L 105.5183351 120.6880104 90.34865986 0.748613384 -0.417707253 0.366954739 1 0.460261348 0.338792097 151742 "protein phosphatase, Mg2+/Mn2+ dependent 1L" "GO:0000165,GO:0004722,GO:0004724,GO:0005789,GO:0006470,GO:0007178,GO:0016021,GO:0030148,GO:0046872,GO:0070062,GO:0106306,GO:0106307" MAPK cascade|protein serine/threonine phosphatase activity|magnesium-dependent protein serine/threonine phosphatase activity|endoplasmic reticulum membrane|protein dephosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|integral component of membrane|sphingolipid biosynthetic process|metal ion binding|extracellular exosome|protein serine phosphatase activity|protein threonine phosphatase activity PPM1M 523.2173984 526.4494246 519.9853722 0.987721418 -0.017823901 0.955169288 1 11.52405177 11.19208115 132160 "protein phosphatase, Mg2+/Mn2+ dependent 1M" "GO:0004724,GO:0005634,GO:0006470,GO:0030145,GO:0106306,GO:0106307" magnesium-dependent protein serine/threonine phosphatase activity|nucleus|protein dephosphorylation|manganese ion binding|protein serine phosphatase activity|protein threonine phosphatase activity PPM1N 33.66499617 38.49531366 28.83467868 0.749043869 -0.41687788 0.568658378 1 1.173286201 0.864136591 147699 "protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)" "GO:0000287,GO:0005634,GO:0005829,GO:0006470,GO:0030145,GO:0043124,GO:0090263,GO:0106306,GO:0106307" magnesium ion binding|nucleus|cytosol|protein dephosphorylation|manganese ion binding|negative regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of canonical Wnt signaling pathway|protein serine phosphatase activity|protein threonine phosphatase activity PPME1 1243.599487 1232.890451 1254.308523 1.017372242 0.024847638 0.921494215 1 23.95234707 23.96067999 51400 protein phosphatase methylesterase 1 "GO:0000086,GO:0004864,GO:0005515,GO:0005654,GO:0006482,GO:0018215,GO:0019888,GO:0019901,GO:0019903,GO:0032515,GO:0045296,GO:0051721,GO:0051722,GO:0051723" G2/M transition of mitotic cell cycle|protein phosphatase inhibitor activity|protein binding|nucleoplasm|protein demethylation|protein phosphopantetheinylation|protein phosphatase regulator activity|protein kinase binding|protein phosphatase binding|negative regulation of phosphoprotein phosphatase activity|cadherin binding|protein phosphatase 2A binding|protein C-terminal methylesterase activity|protein methylesterase activity PPOX 428.4944613 449.4587973 407.5301253 0.90671298 -0.141282158 0.623517535 1 6.734079153 6.003703392 5498 protoporphyrinogen oxidase "GO:0004729,GO:0005758,GO:0006779,GO:0006782,GO:0006783,GO:0016491,GO:0031304,GO:0031305,GO:0031966,GO:0042493,GO:0050660,GO:0055114" oxygen-dependent protoporphyrinogen oxidase activity|mitochondrial intermembrane space|porphyrin-containing compound biosynthetic process|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|oxidoreductase activity|intrinsic component of mitochondrial inner membrane|integral component of mitochondrial inner membrane|mitochondrial membrane|response to drug|flavin adenine dinucleotide binding|oxidation-reduction process hsa00860 Porphyrin and chlorophyll metabolism PPP1CA 3592.439119 3283.546214 3901.332025 1.188145917 0.248712025 0.295064692 1 120.5205134 140.7997655 5499 protein phosphatase 1 catalytic subunit alpha "GO:0000164,GO:0000781,GO:0004721,GO:0004722,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0005977,GO:0005979,GO:0005981,GO:0006470,GO:0007049,GO:0008157,GO:0010288,GO:0016032,GO:0016311,GO:0016791,GO:0030324,GO:0032091,GO:0032922,GO:0035970,GO:0036496,GO:0042587,GO:0042752,GO:0043021,GO:0043153,GO:0043197,GO:0043204,GO:0046872,GO:0048754,GO:0051301,GO:0060828,GO:0070062,GO:0070262,GO:0072357,GO:0098609,GO:0098641,GO:0098793,GO:0098978,GO:0106306,GO:0106307,GO:1904886,GO:2001241" "protein phosphatase type 1 complex|chromosome, telomeric region|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|adherens junction|glycogen metabolic process|regulation of glycogen biosynthetic process|regulation of glycogen catabolic process|protein dephosphorylation|cell cycle|protein phosphatase 1 binding|response to lead ion|viral process|dephosphorylation|phosphatase activity|lung development|negative regulation of protein binding|circadian regulation of gene expression|peptidyl-threonine dephosphorylation|regulation of translational initiation by eIF2 alpha dephosphorylation|glycogen granule|regulation of circadian rhythm|ribonucleoprotein complex binding|entrainment of circadian clock by photoperiod|dendritic spine|perikaryon|metal ion binding|branching morphogenesis of an epithelial tube|cell division|regulation of canonical Wnt signaling pathway|extracellular exosome|peptidyl-serine dephosphorylation|PTW/PP1 phosphatase complex|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|presynapse|glutamatergic synapse|protein serine phosphatase activity|protein threonine phosphatase activity|beta-catenin destruction complex disassembly|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa03015,hsa04022,hsa04024,hsa04114,hsa04218,hsa04261,hsa04270,hsa04390,hsa04510,hsa04611,hsa04720,hsa04728,hsa04750,hsa04810,hsa04910,hsa04921,hsa04931,hsa05031,hsa05034,hsa05168,hsa05205" mRNA surveillance pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Hippo signaling pathway|Focal adhesion|Platelet activation|Long-term potentiation|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Oxytocin signaling pathway|Insulin resistance|Amphetamine addiction|Alcoholism|Herpes simplex virus 1 infection|Proteoglycans in cancer PPP1CB 3536.6468 3395.910913 3677.382688 1.0828855 0.114880706 0.628994983 1 35.30752465 37.59421217 5500 protein phosphatase 1 catalytic subunit beta "GO:0000086,GO:0000164,GO:0000781,GO:0004722,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0005977,GO:0005979,GO:0005981,GO:0006470,GO:0016791,GO:0017018,GO:0019901,GO:0030155,GO:0032922,GO:0042587,GO:0042752,GO:0043153,GO:0046872,GO:0050115,GO:0051301,GO:0070062,GO:0072357,GO:0106306,GO:0106307" "G2/M transition of mitotic cell cycle|protein phosphatase type 1 complex|chromosome, telomeric region|protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|focal adhesion|glycogen metabolic process|regulation of glycogen biosynthetic process|regulation of glycogen catabolic process|protein dephosphorylation|phosphatase activity|myosin phosphatase activity|protein kinase binding|regulation of cell adhesion|circadian regulation of gene expression|glycogen granule|regulation of circadian rhythm|entrainment of circadian clock by photoperiod|metal ion binding|myosin-light-chain-phosphatase activity|cell division|extracellular exosome|PTW/PP1 phosphatase complex|protein serine phosphatase activity|protein threonine phosphatase activity" "hsa03015,hsa04022,hsa04024,hsa04114,hsa04218,hsa04261,hsa04270,hsa04390,hsa04510,hsa04611,hsa04720,hsa04728,hsa04750,hsa04810,hsa04910,hsa04921,hsa04931,hsa05031,hsa05034,hsa05168,hsa05205" mRNA surveillance pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Hippo signaling pathway|Focal adhesion|Platelet activation|Long-term potentiation|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Oxytocin signaling pathway|Insulin resistance|Amphetamine addiction|Alcoholism|Herpes simplex virus 1 infection|Proteoglycans in cancer PPP1CC 5685.067752 5092.825956 6277.309549 1.232578848 0.301679939 0.211700295 1 80.79511327 97.91990496 5501 protein phosphatase 1 catalytic subunit gamma "GO:0000164,GO:0000777,GO:0000781,GO:0003723,GO:0004721,GO:0004722,GO:0005515,GO:0005521,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005741,GO:0005829,GO:0005925,GO:0005977,GO:0006470,GO:0007049,GO:0008022,GO:0008157,GO:0016607,GO:0016791,GO:0019901,GO:0019904,GO:0030182,GO:0030496,GO:0032154,GO:0032922,GO:0032991,GO:0042752,GO:0043153,GO:0043197,GO:0044877,GO:0046822,GO:0046872,GO:0047485,GO:0051301,GO:0060252,GO:0072357,GO:0098793,GO:0098978,GO:0106306,GO:0106307" "protein phosphatase type 1 complex|condensed chromosome kinetochore|chromosome, telomeric region|RNA binding|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein binding|lamin binding|nucleus|nucleolus|cytoplasm|mitochondrion|mitochondrial outer membrane|cytosol|focal adhesion|glycogen metabolic process|protein dephosphorylation|cell cycle|protein C-terminus binding|protein phosphatase 1 binding|nuclear speck|phosphatase activity|protein kinase binding|protein domain specific binding|neuron differentiation|midbody|cleavage furrow|circadian regulation of gene expression|protein-containing complex|regulation of circadian rhythm|entrainment of circadian clock by photoperiod|dendritic spine|protein-containing complex binding|regulation of nucleocytoplasmic transport|metal ion binding|protein N-terminus binding|cell division|positive regulation of glial cell proliferation|PTW/PP1 phosphatase complex|presynapse|glutamatergic synapse|protein serine phosphatase activity|protein threonine phosphatase activity" "hsa03015,hsa04022,hsa04024,hsa04114,hsa04218,hsa04261,hsa04270,hsa04390,hsa04510,hsa04611,hsa04720,hsa04728,hsa04750,hsa04810,hsa04910,hsa04921,hsa04931,hsa05031,hsa05034,hsa05168,hsa05205" mRNA surveillance pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Hippo signaling pathway|Focal adhesion|Platelet activation|Long-term potentiation|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Oxytocin signaling pathway|Insulin resistance|Amphetamine addiction|Alcoholism|Herpes simplex virus 1 infection|Proteoglycans in cancer PPP1R10 587.8174083 620.0866741 555.5481426 0.895920144 -0.158557948 0.551041006 1 6.952287001 6.124465215 5514 protein phosphatase 1 regulatory subunit 10 "GO:0000781,GO:0000785,GO:0003677,GO:0003723,GO:0004864,GO:0005515,GO:0005634,GO:0005654,GO:0006606,GO:0010667,GO:0016604,GO:0032206,GO:0032515,GO:0046872,GO:0072357,GO:1904290" "chromosome, telomeric region|chromatin|DNA binding|RNA binding|protein phosphatase inhibitor activity|protein binding|nucleus|nucleoplasm|protein import into nucleus|negative regulation of cardiac muscle cell apoptotic process|nuclear body|positive regulation of telomere maintenance|negative regulation of phosphoprotein phosphatase activity|metal ion binding|PTW/PP1 phosphatase complex|negative regulation of mitotic DNA damage checkpoint" PPP1R11 690.8240275 712.6835096 668.9645454 0.93865585 -0.091331792 0.726162463 1 20.38296305 18.81242956 6992 protein phosphatase 1 regulatory inhibitor subunit 11 "GO:0001818,GO:0004865,GO:0005515,GO:0005634,GO:0005737,GO:0006511,GO:0008157,GO:0016567,GO:0032515,GO:0050830,GO:0061630" negative regulation of cytokine production|protein serine/threonine phosphatase inhibitor activity|protein binding|nucleus|cytoplasm|ubiquitin-dependent protein catabolic process|protein phosphatase 1 binding|protein ubiquitination|negative regulation of phosphoprotein phosphatase activity|defense response to Gram-positive bacterium|ubiquitin protein ligase activity PPP1R12A 2587.98134 2512.599527 2663.363154 1.060003047 0.084068412 0.723226658 1 22.92968857 23.89881946 4659 protein phosphatase 1 regulatory subunit 12A "GO:0000086,GO:0000278,GO:0000776,GO:0004857,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0005925,GO:0006470,GO:0007098,GO:0007165,GO:0015629,GO:0019208,GO:0019901,GO:0030018,GO:0030155,GO:0031672,GO:0035507,GO:0035508,GO:0035690,GO:0043086,GO:0043292,GO:0045944,GO:0046822,GO:0071889,GO:0072357,GO:1903140" G2/M transition of mitotic cell cycle|mitotic cell cycle|kinetochore|enzyme inhibitor activity|protein binding|nucleoplasm|nucleolus|cytoplasm|centrosome|cytosol|plasma membrane|focal adhesion|protein dephosphorylation|centrosome cycle|signal transduction|actin cytoskeleton|phosphatase regulator activity|protein kinase binding|Z disc|regulation of cell adhesion|A band|regulation of myosin-light-chain-phosphatase activity|positive regulation of myosin-light-chain-phosphatase activity|cellular response to drug|negative regulation of catalytic activity|contractile fiber|positive regulation of transcription by RNA polymerase II|regulation of nucleocytoplasmic transport|14-3-3 protein binding|PTW/PP1 phosphatase complex|regulation of establishment of endothelial barrier "hsa04022,hsa04024,hsa04270,hsa04510,hsa04611,hsa04810,hsa04921,hsa05205" cGMP-PKG signaling pathway|cAMP signaling pathway|Vascular smooth muscle contraction|Focal adhesion|Platelet activation|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Proteoglycans in cancer PPP1R12B 397.2669536 424.4888641 370.0450431 0.87174264 -0.198025816 0.497613623 1 1.487276162 1.274826507 4660 protein phosphatase 1 regulatory subunit 12B "GO:0000086,GO:0004857,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006937,GO:0007165,GO:0008047,GO:0019208,GO:0019901,GO:0030018,GO:0031672,GO:0043086" G2/M transition of mitotic cell cycle|enzyme inhibitor activity|protein binding|nucleoplasm|cytoplasm|cytosol|cytoskeleton|regulation of muscle contraction|signal transduction|enzyme activator activity|phosphatase regulator activity|protein kinase binding|Z disc|A band|negative regulation of catalytic activity "hsa04270,hsa04510,hsa04810,hsa04921,hsa05205" Vascular smooth muscle contraction|Focal adhesion|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Proteoglycans in cancer PPP1R12C 1053.059093 1012.322708 1093.795478 1.080481026 0.111673738 0.650484133 1 17.99660305 19.11960258 54776 protein phosphatase 1 regulatory subunit 12C "GO:0004857,GO:0005515,GO:0005737,GO:0005856,GO:0007165,GO:0019208,GO:0019901,GO:0043086" enzyme inhibitor activity|protein binding|cytoplasm|cytoskeleton|signal transduction|phosphatase regulator activity|protein kinase binding|negative regulation of catalytic activity "hsa04270,hsa04510,hsa04810,hsa04921,hsa05205" Vascular smooth muscle contraction|Focal adhesion|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Proteoglycans in cancer PPP1R13B 390.6923473 441.1354862 340.2492084 0.771303192 -0.374630014 0.198170303 1 3.382070123 2.564950067 23368 protein phosphatase 1 regulatory subunit 13B "GO:0002039,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0008134,GO:0042981,GO:0045786,GO:0048471,GO:0072332,GO:1900740,GO:1901216,GO:1901796" p53 binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|plasma membrane|transcription factor binding|regulation of apoptotic process|negative regulation of cell cycle|perinuclear region of cytoplasm|intrinsic apoptotic signaling pathway by p53 class mediator|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of neuron death|regulation of signal transduction by p53 class mediator PPP1R13L 1455.682216 1362.942186 1548.422245 1.136087987 0.184074572 0.441948152 1 21.54553303 24.06802141 10848 protein phosphatase 1 regulatory subunit 13 like "GO:0000122,GO:0003215,GO:0003229,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006357,GO:0006915,GO:0008134,GO:0009791,GO:0030054,GO:0031076,GO:0035264,GO:0042633,GO:0042802,GO:0045171,GO:0045296,GO:0045597,GO:0048871,GO:0060048,GO:1901796" "negative regulation of transcription by RNA polymerase II|cardiac right ventricle morphogenesis|ventricular cardiac muscle tissue development|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription by RNA polymerase II|apoptotic process|transcription factor binding|post-embryonic development|cell junction|embryonic camera-type eye development|multicellular organism growth|hair cycle|identical protein binding|intercellular bridge|cadherin binding|positive regulation of cell differentiation|multicellular organismal homeostasis|cardiac muscle contraction|regulation of signal transduction by p53 class mediator" PPP1R14B 1865.499531 1650.096418 2080.902645 1.261079427 0.334659144 0.157831923 1 89.04207591 110.4101235 26472 protein phosphatase 1 regulatory inhibitor subunit 14B "GO:0004865,GO:0005737,GO:0032515,GO:0042325,GO:0045087" protein serine/threonine phosphatase inhibitor activity|cytoplasm|negative regulation of phosphoprotein phosphatase activity|regulation of phosphorylation|innate immune response PPP1R15A 3046.97747 3396.951327 2697.003613 0.793948265 -0.332883093 0.159818832 1 77.14427616 60.22365245 23645 protein phosphatase 1 regulatory subunit 15A "GO:0000164,GO:0005515,GO:0005737,GO:0005739,GO:0005741,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006915,GO:0006974,GO:0007050,GO:0008157,GO:0016020,GO:0019888,GO:0019901,GO:0032058,GO:0032515,GO:0032516,GO:0034976,GO:0035308,GO:0036496,GO:0070059,GO:0070972,GO:0072542,GO:1902310,GO:1903898,GO:1903917" protein phosphatase type 1 complex|protein binding|cytoplasm|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|apoptotic process|cellular response to DNA damage stimulus|cell cycle arrest|protein phosphatase 1 binding|membrane|protein phosphatase regulator activity|protein kinase binding|positive regulation of translational initiation in response to stress|negative regulation of phosphoprotein phosphatase activity|positive regulation of phosphoprotein phosphatase activity|response to endoplasmic reticulum stress|negative regulation of protein dephosphorylation|regulation of translational initiation by eIF2 alpha dephosphorylation|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|protein localization to endoplasmic reticulum|protein phosphatase activator activity|positive regulation of peptidyl-serine dephosphorylation|negative regulation of PERK-mediated unfolded protein response|positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation hsa04141 Protein processing in endoplasmic reticulum PPP1R15B 1390.616105 1332.770184 1448.462026 1.086805545 0.120093831 0.617831691 1 11.35677713 12.13607152 84919 protein phosphatase 1 regulatory subunit 15B "GO:0000164,GO:0001933,GO:0005515,GO:0005783,GO:0006983,GO:0019888,GO:0032516,GO:0034976,GO:0042542,GO:0070262,GO:1903898,GO:1903912" protein phosphatase type 1 complex|negative regulation of protein phosphorylation|protein binding|endoplasmic reticulum|ER overload response|protein phosphatase regulator activity|positive regulation of phosphoprotein phosphatase activity|response to endoplasmic reticulum stress|response to hydrogen peroxide|peptidyl-serine dephosphorylation|negative regulation of PERK-mediated unfolded protein response|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation PPP1R16A 698.1962434 704.3601985 692.0322883 0.982497719 -0.025474037 0.926689692 1 11.15773501 10.77900745 84988 protein phosphatase 1 regulatory subunit 16A "GO:0005515,GO:0005886,GO:0008157,GO:0017020,GO:0019888,GO:0035304,GO:0043666" protein binding|plasma membrane|protein phosphatase 1 binding|myosin phosphatase regulator activity|protein phosphatase regulator activity|regulation of protein dephosphorylation|regulation of phosphoprotein phosphatase activity PPP1R18 2754.04747 2645.772504 2862.322437 1.081847526 0.113497182 0.632077149 1 41.01075103 43.62495152 170954 protein phosphatase 1 regulatory subunit 18 "GO:0003779,GO:0005515,GO:0005737,GO:0005856,GO:0019902" actin binding|protein binding|cytoplasm|cytoskeleton|phosphatase binding PPP1R1C 34.26949145 29.13158871 39.4073942 1.352737559 0.435881973 0.547391819 1 0.412934754 0.549245064 151242 protein phosphatase 1 regulatory inhibitor subunit 1C "GO:0004864,GO:0005515,GO:0005737,GO:0007049,GO:0032515,GO:0035556,GO:0051301" protein phosphatase inhibitor activity|protein binding|cytoplasm|cell cycle|negative regulation of phosphoprotein phosphatase activity|intracellular signal transduction|cell division PPP1R2 1074.342918 1066.42423 1082.261606 1.014850916 0.021267808 0.934667341 1 15.9913181 15.95723677 5504 protein phosphatase 1 regulatory inhibitor subunit 2 "GO:0004864,GO:0004865,GO:0005515,GO:0005977,GO:0006091,GO:0009966,GO:0032515,GO:0043666" protein phosphatase inhibitor activity|protein serine/threonine phosphatase inhibitor activity|protein binding|glycogen metabolic process|generation of precursor metabolites and energy|regulation of signal transduction|negative regulation of phosphoprotein phosphatase activity|regulation of phosphoprotein phosphatase activity PPP1R21 547.7218449 538.9343912 556.5092985 1.032610477 0.04629614 0.869394088 1 8.960105277 9.097473893 129285 protein phosphatase 1 regulatory subunit 21 "GO:0005769,GO:0016020" early endosome|membrane PPP1R26 1840.182384 1666.74304 2013.621728 1.208117676 0.272760986 0.249847249 1 11.3270104 13.45537223 9858 protein phosphatase 1 regulatory subunit 26 "GO:0004864,GO:0005515,GO:0005730,GO:0010923,GO:0032515" protein phosphatase inhibitor activity|protein binding|nucleolus|negative regulation of phosphatase activity|negative regulation of phosphoprotein phosphatase activity PPP1R2B 9.606529142 12.48496659 6.728091692 0.53889545 -0.891922689 0.47680615 1 0.298254127 0.15803823 153743 PPP1R2 family member B "GO:0004864,GO:0005515,GO:0005977,GO:0009966,GO:0032515,GO:0043666" protein phosphatase inhibitor activity|protein binding|glycogen metabolic process|regulation of signal transduction|negative regulation of phosphoprotein phosphatase activity|regulation of phosphoprotein phosphatase activity PPP1R32 11.93016111 10.40413883 13.45618338 1.29334908 0.371111717 0.792410181 1 0.362434574 0.460910452 220004 protein phosphatase 1 regulatory subunit 32 "GO:0005515,GO:0019902,GO:0036064" protein binding|phosphatase binding|ciliary basal body PPP1R35 948.1653747 832.3311061 1063.999643 1.278336993 0.354268207 0.151637016 1 42.67049123 53.6344928 221908 protein phosphatase 1 regulatory subunit 35 "GO:0004864,GO:0010923,GO:0019902,GO:0032515" protein phosphatase inhibitor activity|negative regulation of phosphatase activity|phosphatase binding|negative regulation of phosphoprotein phosphatase activity PPP1R36 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.106915873 0.161863839 145376 protein phosphatase 1 regulatory subunit 36 "GO:0004864,GO:0010923,GO:0019902,GO:0032515" protein phosphatase inhibitor activity|negative regulation of phosphatase activity|phosphatase binding|negative regulation of phosphoprotein phosphatase activity PPP1R37 431.2986713 447.3779695 415.219373 0.928117613 -0.107620457 0.710049526 1 8.087987801 7.380991077 284352 protein phosphatase 1 regulatory subunit 37 "GO:0004864,GO:0005515,GO:0010923,GO:0032515" protein phosphatase inhibitor activity|protein binding|negative regulation of phosphatase activity|negative regulation of phosphoprotein phosphatase activity PPP1R3B 965.9851601 1035.211813 896.7585069 0.86625606 -0.207134554 0.401816981 1 9.678933398 8.244132553 79660 protein phosphatase 1 regulatory subunit 3B "GO:0000164,GO:0005515,GO:0005977,GO:0005979,GO:0005981,GO:0006470,GO:0008157,GO:0019888,GO:0042587,GO:0043231,GO:0043666,GO:0050196,GO:2001069" protein phosphatase type 1 complex|protein binding|glycogen metabolic process|regulation of glycogen biosynthetic process|regulation of glycogen catabolic process|protein dephosphorylation|protein phosphatase 1 binding|protein phosphatase regulator activity|glycogen granule|intracellular membrane-bounded organelle|regulation of phosphoprotein phosphatase activity|[phosphorylase] phosphatase activity|glycogen binding "hsa04910,hsa04931" Insulin signaling pathway|Insulin resistance PPP1R3C 190.2038549 161.2641518 219.143558 1.358910555 0.442450499 0.233603461 1 3.387001728 4.525613577 5507 protein phosphatase 1 regulatory subunit 3C "GO:0000164,GO:0004722,GO:0005515,GO:0005829,GO:0005977,GO:0005978,GO:0005979,GO:0006470,GO:0008157,GO:0019903,GO:2001069" protein phosphatase type 1 complex|protein serine/threonine phosphatase activity|protein binding|cytosol|glycogen metabolic process|glycogen biosynthetic process|regulation of glycogen biosynthetic process|protein dephosphorylation|protein phosphatase 1 binding|protein phosphatase binding|glycogen binding "hsa04910,hsa04931" Insulin signaling pathway|Insulin resistance PPP1R3D 200.8111689 174.7895323 226.8328056 1.297748227 0.376010517 0.302210411 1 2.560580864 3.267383551 5509 protein phosphatase 1 regulatory subunit 3D "GO:0000164,GO:0004722,GO:0005515,GO:0005977,GO:0005979,GO:0005981,GO:0006470,GO:0008157,GO:0042587,GO:0043231,GO:2001069" protein phosphatase type 1 complex|protein serine/threonine phosphatase activity|protein binding|glycogen metabolic process|regulation of glycogen biosynthetic process|regulation of glycogen catabolic process|protein dephosphorylation|protein phosphatase 1 binding|glycogen granule|intracellular membrane-bounded organelle|glycogen binding "hsa04910,hsa04931" Insulin signaling pathway|Insulin resistance PPP1R3E 149.9887902 177.9107739 122.0668064 0.686112503 -0.543482938 0.180472072 1 1.988433721 1.341459705 90673 protein phosphatase 1 regulatory subunit 3E "GO:0000164,GO:0005977,GO:0005979,GO:0006470,GO:0008157,GO:0042587,GO:0045725,GO:0050196,GO:2001069" protein phosphatase type 1 complex|glycogen metabolic process|regulation of glycogen biosynthetic process|protein dephosphorylation|protein phosphatase 1 binding|glycogen granule|positive regulation of glycogen biosynthetic process|[phosphorylase] phosphatase activity|glycogen binding "hsa04910,hsa04931" Insulin signaling pathway|Insulin resistance PPP1R3F 116.655917 110.2838716 123.0279624 1.115557158 0.157764436 0.736856461 1 0.638980299 0.700890985 89801 protein phosphatase 1 regulatory subunit 3F "GO:0000164,GO:0005979,GO:0008157,GO:0016020,GO:0016021,GO:0019903,GO:2000465,GO:2001069" protein phosphatase type 1 complex|regulation of glycogen biosynthetic process|protein phosphatase 1 binding|membrane|integral component of membrane|protein phosphatase binding|regulation of glycogen (starch) synthase activity|glycogen binding hsa04910 Insulin signaling pathway PPP1R3G 72.18546192 53.06110801 91.30981582 1.720842614 0.783115156 0.136861599 1 0.682848761 1.155411954 648791 protein phosphatase 1 regulatory subunit 3G "GO:0000164,GO:0005979,GO:0008157,GO:0042593,GO:0045725,GO:2000467,GO:2001069" protein phosphatase type 1 complex|regulation of glycogen biosynthetic process|protein phosphatase 1 binding|glucose homeostasis|positive regulation of glycogen biosynthetic process|positive regulation of glycogen (starch) synthase activity|glycogen binding PPP1R42 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.076235666 0.046166382 286187 protein phosphatase 1 regulatory subunit 42 "GO:0002177,GO:0003779,GO:0005737,GO:0005813,GO:0005815,GO:0010921,GO:0015630,GO:0015631,GO:0070840" manchette|actin binding|cytoplasm|centrosome|microtubule organizing center|regulation of phosphatase activity|microtubule cytoskeleton|tubulin binding|dynein complex binding PPP1R7 976.1376626 885.3922141 1066.883111 1.204983615 0.26901353 0.275257735 1 18.21578843 21.58242765 5510 protein phosphatase 1 regulatory subunit 7 "GO:0005515,GO:0005634,GO:0005694,GO:0005737,GO:0019888,GO:0030234,GO:0035307,GO:0043666,GO:0070062" protein binding|nucleus|chromosome|cytoplasm|protein phosphatase regulator activity|enzyme regulator activity|positive regulation of protein dephosphorylation|regulation of phosphoprotein phosphatase activity|extracellular exosome PPP1R8 866.8678241 931.170425 802.5652233 0.861888653 -0.214426595 0.390675238 1 22.58857007 19.14304769 5511 protein phosphatase 1 regulatory subunit 8 "GO:0003677,GO:0003723,GO:0003729,GO:0004519,GO:0004865,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0006397,GO:0006401,GO:0008283,GO:0008380,GO:0008995,GO:0016607,GO:0032515,GO:0035308,GO:0090501" DNA binding|RNA binding|mRNA binding|endonuclease activity|protein serine/threonine phosphatase inhibitor activity|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|mRNA processing|RNA catabolic process|cell population proliferation|RNA splicing|ribonuclease E activity|nuclear speck|negative regulation of phosphoprotein phosphatase activity|negative regulation of protein dephosphorylation|RNA phosphodiester bond hydrolysis PPP1R9A 320.0926583 328.7707869 311.4145297 0.947208639 -0.078245855 0.808603726 1 1.043280571 0.971668108 55607 protein phosphatase 1 regulatory subunit 9A "GO:0005515,GO:0005737,GO:0005829,GO:0007015,GO:0007568,GO:0008022,GO:0008157,GO:0010976,GO:0014069,GO:0015629,GO:0019722,GO:0019901,GO:0019904,GO:0030175,GO:0030425,GO:0030833,GO:0030864,GO:0031175,GO:0031594,GO:0042802,GO:0043025,GO:0044325,GO:0044326,GO:0045860,GO:0051015,GO:0051020,GO:0051489,GO:0051497,GO:0051823,GO:0051963,GO:0060079,GO:0060999,GO:0061001,GO:0097237,GO:0098871,GO:0098974,GO:0098978,GO:1900272,GO:1900454,GO:1904049,GO:1990761" protein binding|cytoplasm|cytosol|actin filament organization|aging|protein C-terminus binding|protein phosphatase 1 binding|positive regulation of neuron projection development|postsynaptic density|actin cytoskeleton|calcium-mediated signaling|protein kinase binding|protein domain specific binding|filopodium|dendrite|regulation of actin filament polymerization|cortical actin cytoskeleton|neuron projection development|neuromuscular junction|identical protein binding|neuronal cell body|ion channel binding|dendritic spine neck|positive regulation of protein kinase activity|actin filament binding|GTPase binding|regulation of filopodium assembly|negative regulation of stress fiber assembly|regulation of synapse structural plasticity|regulation of synapse assembly|excitatory postsynaptic potential|positive regulation of dendritic spine development|regulation of dendritic spine morphogenesis|cellular response to toxic substance|postsynaptic actin cytoskeleton|postsynaptic actin cytoskeleton organization|glutamatergic synapse|negative regulation of long-term synaptic potentiation|positive regulation of long-term synaptic depression|negative regulation of spontaneous neurotransmitter secretion|growth cone lamellipodium PPP1R9B 1316.859347 1402.477914 1231.24078 0.877903864 -0.187865131 0.43535373 1 17.77010176 15.33938875 84687 protein phosphatase 1 regulatory subunit 9B "GO:0000164,GO:0001560,GO:0001932,GO:0001975,GO:0003006,GO:0004672,GO:0004864,GO:0005515,GO:0005654,GO:0005737,GO:0005886,GO:0005912,GO:0006468,GO:0007015,GO:0007050,GO:0007096,GO:0007568,GO:0007612,GO:0008022,GO:0008157,GO:0008380,GO:0014069,GO:0015629,GO:0016358,GO:0016477,GO:0019722,GO:0019900,GO:0021766,GO:0021987,GO:0030027,GO:0030042,GO:0030175,GO:0030308,GO:0030425,GO:0030426,GO:0030864,GO:0031175,GO:0031749,GO:0032515,GO:0032587,GO:0034695,GO:0035094,GO:0035690,GO:0035902,GO:0042127,GO:0043025,GO:0044325,GO:0044326,GO:0044327,GO:0046847,GO:0048545,GO:0050804,GO:0051015,GO:0060179,GO:0061458,GO:0071315,GO:0071364,GO:0071392,GO:0097338,GO:1901653,GO:1903078,GO:1903119,GO:1904372,GO:1904373,GO:1904386,GO:1990778,GO:1990780,GO:2000474" protein phosphatase type 1 complex|regulation of cell growth by extracellular stimulus|regulation of protein phosphorylation|response to amphetamine|developmental process involved in reproduction|protein kinase activity|protein phosphatase inhibitor activity|protein binding|nucleoplasm|cytoplasm|plasma membrane|adherens junction|protein phosphorylation|actin filament organization|cell cycle arrest|regulation of exit from mitosis|aging|learning|protein C-terminus binding|protein phosphatase 1 binding|RNA splicing|postsynaptic density|actin cytoskeleton|dendrite development|cell migration|calcium-mediated signaling|kinase binding|hippocampus development|cerebral cortex development|lamellipodium|actin filament depolymerization|filopodium|negative regulation of cell growth|dendrite|growth cone|cortical actin cytoskeleton|neuron projection development|D2 dopamine receptor binding|negative regulation of phosphoprotein phosphatase activity|ruffle membrane|response to prostaglandin E|response to nicotine|cellular response to drug|response to immobilization stress|regulation of cell population proliferation|neuronal cell body|ion channel binding|dendritic spine neck|dendritic spine head|filopodium assembly|response to steroid hormone|modulation of chemical synaptic transmission|actin filament binding|male mating behavior|reproductive system development|cellular response to morphine|cellular response to epidermal growth factor stimulus|cellular response to estradiol stimulus|response to clozapine|cellular response to peptide|positive regulation of protein localization to plasma membrane|protein localization to actin cytoskeleton|positive regulation of protein localization to actin cortical patch|response to kainic acid|response to L-phenylalanine derivative|protein localization to cell periphery|cytoplasmic side of dendritic spine plasma membrane|regulation of opioid receptor signaling pathway PPP2CA 4911.187408 4470.658454 5351.716363 1.197075647 0.259514324 0.279368995 1 48.41534597 56.98700254 5515 protein phosphatase 2 catalytic subunit alpha "GO:0000159,GO:0000184,GO:0000188,GO:0000775,GO:0000922,GO:0001932,GO:0004721,GO:0004722,GO:0005515,GO:0005634,GO:0005739,GO:0005829,GO:0005886,GO:0006275,GO:0006355,GO:0006470,GO:0006672,GO:0006915,GO:0007084,GO:0007498,GO:0008022,GO:0008380,GO:0010033,GO:0010288,GO:0010719,GO:0015630,GO:0016020,GO:0019932,GO:0030111,GO:0030155,GO:0030308,GO:0035970,GO:0040008,GO:0042532,GO:0045121,GO:0045202,GO:0045595,GO:0046872,GO:0046982,GO:0048156,GO:0050811,GO:0051321,GO:0070062,GO:0070262,GO:0071902,GO:0106306,GO:0106307,GO:1904526,GO:1904528" "protein phosphatase type 2A complex|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|inactivation of MAPK activity|chromosome, centromeric region|spindle pole|regulation of protein phosphorylation|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein binding|nucleus|mitochondrion|cytosol|plasma membrane|regulation of DNA replication|regulation of transcription, DNA-templated|protein dephosphorylation|ceramide metabolic process|apoptotic process|mitotic nuclear envelope reassembly|mesoderm development|protein C-terminus binding|RNA splicing|response to organic substance|response to lead ion|negative regulation of epithelial to mesenchymal transition|microtubule cytoskeleton|membrane|second-messenger-mediated signaling|regulation of Wnt signaling pathway|regulation of cell adhesion|negative regulation of cell growth|peptidyl-threonine dephosphorylation|regulation of growth|negative regulation of tyrosine phosphorylation of STAT protein|membrane raft|synapse|regulation of cell differentiation|metal ion binding|protein heterodimerization activity|tau protein binding|GABA receptor binding|meiotic cell cycle|extracellular exosome|peptidyl-serine dephosphorylation|positive regulation of protein serine/threonine kinase activity|protein serine phosphatase activity|protein threonine phosphatase activity|regulation of microtubule binding|positive regulation of microtubule binding" "hsa03015,hsa04071,hsa04114,hsa04136,hsa04140,hsa04151,hsa04152,hsa04261,hsa04350,hsa04390,hsa04530,hsa04728,hsa04730,hsa05142,hsa05160,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|Autophagy - other|Autophagy - animal|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|TGF-beta signaling pathway|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Long-term depression|Chagas disease|Hepatitis C|Human papillomavirus infection PPP2CB 1617.487925 1434.730744 1800.245106 1.254761643 0.327413333 0.168769798 1 39.34683602 48.54474544 5516 protein phosphatase 2 catalytic subunit beta "GO:0000159,GO:0000775,GO:0000922,GO:0004722,GO:0005515,GO:0005634,GO:0005829,GO:0006470,GO:0008022,GO:0008637,GO:0010288,GO:0010468,GO:0034976,GO:0035970,GO:0042542,GO:0043161,GO:0046580,GO:0046677,GO:0046872,GO:0048156,GO:0070262,GO:0106306,GO:0106307,GO:1904528" "protein phosphatase type 2A complex|chromosome, centromeric region|spindle pole|protein serine/threonine phosphatase activity|protein binding|nucleus|cytosol|protein dephosphorylation|protein C-terminus binding|apoptotic mitochondrial changes|response to lead ion|regulation of gene expression|response to endoplasmic reticulum stress|peptidyl-threonine dephosphorylation|response to hydrogen peroxide|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of Ras protein signal transduction|response to antibiotic|metal ion binding|tau protein binding|peptidyl-serine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity|positive regulation of microtubule binding" "hsa03015,hsa04071,hsa04114,hsa04136,hsa04140,hsa04151,hsa04152,hsa04261,hsa04350,hsa04390,hsa04530,hsa04728,hsa04730,hsa05142,hsa05160,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|Autophagy - other|Autophagy - animal|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|TGF-beta signaling pathway|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Long-term depression|Chagas disease|Hepatitis C|Human papillomavirus infection PPP2R1A 3910.773627 3503.073543 4318.47371 1.232767071 0.301900231 0.204712759 1 31.9522469 38.7305449 5518 protein phosphatase 2 scaffold subunit Aalpha "GO:0000086,GO:0000159,GO:0000184,GO:0000188,GO:0000775,GO:0004722,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006275,GO:0006355,GO:0006470,GO:0006672,GO:0006915,GO:0007059,GO:0007084,GO:0008287,GO:0008380,GO:0010033,GO:0010389,GO:0015630,GO:0016020,GO:0016328,GO:0019888,GO:0019932,GO:0030111,GO:0030155,GO:0030308,GO:0030425,GO:0040008,GO:0042532,GO:0043666,GO:0045595,GO:0046982,GO:0065003,GO:0070062,GO:0097711,GO:1990405" "G2/M transition of mitotic cell cycle|protein phosphatase type 2A complex|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|inactivation of MAPK activity|chromosome, centromeric region|protein serine/threonine phosphatase activity|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|regulation of DNA replication|regulation of transcription, DNA-templated|protein dephosphorylation|ceramide metabolic process|apoptotic process|chromosome segregation|mitotic nuclear envelope reassembly|protein serine/threonine phosphatase complex|RNA splicing|response to organic substance|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|membrane|lateral plasma membrane|protein phosphatase regulator activity|second-messenger-mediated signaling|regulation of Wnt signaling pathway|regulation of cell adhesion|negative regulation of cell growth|dendrite|regulation of growth|negative regulation of tyrosine phosphorylation of STAT protein|regulation of phosphoprotein phosphatase activity|regulation of cell differentiation|protein heterodimerization activity|protein-containing complex assembly|extracellular exosome|ciliary basal body-plasma membrane docking|protein antigen binding" "hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04350,hsa04390,hsa04530,hsa04728,hsa04730,hsa05142,hsa05160,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|TGF-beta signaling pathway|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Long-term depression|Chagas disease|Hepatitis C|Human papillomavirus infection PPP2R1B 983.9055538 988.3931885 979.4179192 0.990919333 -0.013160477 0.961896569 1 4.966455878 4.839004899 5519 protein phosphatase 2 scaffold subunit Abeta "GO:0000159,GO:0004722,GO:0005515,GO:0005737,GO:0006470,GO:0008287,GO:0019888,GO:0043666,GO:0045121,GO:0060561,GO:0070062,GO:2001241" protein phosphatase type 2A complex|protein serine/threonine phosphatase activity|protein binding|cytoplasm|protein dephosphorylation|protein serine/threonine phosphatase complex|protein phosphatase regulator activity|regulation of phosphoprotein phosphatase activity|membrane raft|apoptotic process involved in morphogenesis|extracellular exosome|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04350,hsa04390,hsa04530,hsa04728,hsa04730,hsa05142,hsa05160,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|TGF-beta signaling pathway|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Long-term depression|Chagas disease|Hepatitis C|Human papillomavirus infection PPP2R2A 1186.010002 1134.051132 1237.968871 1.091634086 0.126489349 0.603526173 1 16.88678142 18.12571507 5520 protein phosphatase 2 regulatory subunit Balpha "GO:0000086,GO:0000159,GO:0000184,GO:0005515,GO:0005654,GO:0005829,GO:0006470,GO:0007084,GO:0019888,GO:0043278,GO:0043666,GO:0044877,GO:0048156,GO:0051721,GO:0070262,GO:0098978" "G2/M transition of mitotic cell cycle|protein phosphatase type 2A complex|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein binding|nucleoplasm|cytosol|protein dephosphorylation|mitotic nuclear envelope reassembly|protein phosphatase regulator activity|response to morphine|regulation of phosphoprotein phosphatase activity|protein-containing complex binding|tau protein binding|protein phosphatase 2A binding|peptidyl-serine dephosphorylation|glutamatergic synapse" "hsa03015,hsa04071,hsa04151,hsa04152,hsa04261,hsa04390,hsa04530,hsa04728,hsa05142,hsa05160,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Chagas disease|Hepatitis C|Human papillomavirus infection PPP2R2B 5.003924597 5.202069413 4.80577978 0.923820772 -0.11431511 1 1 0.023098834 0.0209821 5521 protein phosphatase 2 regulatory subunit Bbeta "GO:0000159,GO:0005515,GO:0005739,GO:0005741,GO:0005829,GO:0005856,GO:0006915,GO:0019888,GO:0043666,GO:0070262" protein phosphatase type 2A complex|protein binding|mitochondrion|mitochondrial outer membrane|cytosol|cytoskeleton|apoptotic process|protein phosphatase regulator activity|regulation of phosphoprotein phosphatase activity|peptidyl-serine dephosphorylation "hsa03015,hsa04071,hsa04151,hsa04152,hsa04261,hsa04390,hsa04530,hsa04728,hsa05142,hsa05160,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Chagas disease|Hepatitis C|Human papillomavirus infection PPP2R2C 15.21494902 8.323311061 22.10658699 2.655984719 1.409246846 0.147519434 1 0.071737696 0.187345892 5522 protein phosphatase 2 regulatory subunit Bgamma "GO:0000159,GO:0005515,GO:0005829,GO:0019888,GO:0043666,GO:0070262" protein phosphatase type 2A complex|protein binding|cytosol|protein phosphatase regulator activity|regulation of phosphoprotein phosphatase activity|peptidyl-serine dephosphorylation "hsa03015,hsa04071,hsa04151,hsa04152,hsa04261,hsa04390,hsa04530,hsa04728,hsa05142,hsa05160,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Chagas disease|Hepatitis C|Human papillomavirus infection PPP2R2D 795.7334513 754.3000649 837.1668377 1.109859162 0.150376614 0.552681147 1 4.795759843 5.233551195 55844 protein phosphatase 2 regulatory subunit Bdelta "GO:0000159,GO:0000278,GO:0005515,GO:0005829,GO:0010458,GO:0019888,GO:0043666,GO:0051301,GO:0070262" protein phosphatase type 2A complex|mitotic cell cycle|protein binding|cytosol|exit from mitosis|protein phosphatase regulator activity|regulation of phosphoprotein phosphatase activity|cell division|peptidyl-serine dephosphorylation "hsa03015,hsa04071,hsa04151,hsa04152,hsa04261,hsa04390,hsa04530,hsa04728,hsa05142,hsa05160,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Chagas disease|Hepatitis C|Human papillomavirus infection PPP2R3A 1171.715351 1326.5277 1016.903001 0.766590099 -0.38347273 0.113843592 1 9.022985638 6.801185975 5523 protein phosphatase 2 regulatory subunit B''alpha "GO:0000159,GO:0005509,GO:0005515,GO:0006470,GO:0019888,GO:0043666,GO:0061053" protein phosphatase type 2A complex|calcium ion binding|protein binding|protein dephosphorylation|protein phosphatase regulator activity|regulation of phosphoprotein phosphatase activity|somite development "hsa03015,hsa04071,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP2R3B-2 86.54808104 89.47559391 83.62056817 0.934562874 -0.097636369 0.865169578 1 1.378506928 1.266743417 28227 protein phosphatase 2 regulatory subunit B''beta PPP2R3C 556.8578569 526.4494246 587.2662891 1.115522711 0.157719885 0.557842861 1 13.46866645 14.77318692 55012 protein phosphatase 2 regulatory subunit B''gamma "GO:0000226,GO:0001782,GO:0002759,GO:0005515,GO:0005654,GO:0005794,GO:0005813,GO:0005819,GO:0005829,GO:0030865,GO:0032147,GO:0035303,GO:0043029,GO:0045579,GO:0046872,GO:0048536,GO:0051900" microtubule cytoskeleton organization|B cell homeostasis|regulation of antimicrobial humoral response|protein binding|nucleoplasm|Golgi apparatus|centrosome|spindle|cytosol|cortical cytoskeleton organization|activation of protein kinase activity|regulation of dephosphorylation|T cell homeostasis|positive regulation of B cell differentiation|metal ion binding|spleen development|regulation of mitochondrial depolarization "hsa03015,hsa04071,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP2R5A 805.9991959 721.0068207 890.9915712 1.235760253 0.305398877 0.224727075 1 11.05712898 13.43531264 5525 protein phosphatase 2 regulatory subunit B'alpha "GO:0000159,GO:0000775,GO:0004721,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0006470,GO:0007165,GO:0016020,GO:0019888,GO:0019900,GO:0030018,GO:0031430,GO:0031952,GO:0035307,GO:0043666,GO:0072542,GO:0090219,GO:1903077" "protein phosphatase type 2A complex|chromosome, centromeric region|phosphoprotein phosphatase activity|protein binding|nucleus|cytoplasm|centrosome|cytosol|protein dephosphorylation|signal transduction|membrane|protein phosphatase regulator activity|kinase binding|Z disc|M band|regulation of protein autophosphorylation|positive regulation of protein dephosphorylation|regulation of phosphoprotein phosphatase activity|protein phosphatase activator activity|negative regulation of lipid kinase activity|negative regulation of protein localization to plasma membrane" "hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP2R5B 579.1971872 545.1768745 613.2174999 1.12480468 0.169674502 0.524467618 1 9.643714882 10.66578083 5526 protein phosphatase 2 regulatory subunit B'beta "GO:0000159,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006470,GO:0010469,GO:0010976,GO:0014066,GO:0019888,GO:0031334,GO:0031952,GO:0036498,GO:0043666,GO:0045944,GO:0050730,GO:0051091,GO:0051388,GO:0051898,GO:0070317,GO:0071158,GO:0071363,GO:0072542" protein phosphatase type 2A complex|protein binding|nucleus|cytoplasm|cytosol|protein dephosphorylation|regulation of signaling receptor activity|positive regulation of neuron projection development|regulation of phosphatidylinositol 3-kinase signaling|protein phosphatase regulator activity|positive regulation of protein-containing complex assembly|regulation of protein autophosphorylation|IRE1-mediated unfolded protein response|regulation of phosphoprotein phosphatase activity|positive regulation of transcription by RNA polymerase II|regulation of peptidyl-tyrosine phosphorylation|positive regulation of DNA-binding transcription factor activity|positive regulation of neurotrophin TRK receptor signaling pathway|negative regulation of protein kinase B signaling|negative regulation of G0 to G1 transition|positive regulation of cell cycle arrest|cellular response to growth factor stimulus|protein phosphatase activator activity "hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP2R5C 2971.484525 3004.715293 2938.253757 0.977880921 -0.0322693 0.892919687 1 27.98536348 26.90841416 5527 protein phosphatase 2 regulatory subunit B'gamma "GO:0000159,GO:0000775,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006470,GO:0007165,GO:0008285,GO:0014066,GO:0019888,GO:0031952,GO:0043161,GO:0043666,GO:0051898,GO:0072542" "protein phosphatase type 2A complex|chromosome, centromeric region|protein binding|nucleus|nucleoplasm|Golgi apparatus|cytosol|protein dephosphorylation|signal transduction|negative regulation of cell population proliferation|regulation of phosphatidylinositol 3-kinase signaling|protein phosphatase regulator activity|regulation of protein autophosphorylation|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of phosphoprotein phosphatase activity|negative regulation of protein kinase B signaling|protein phosphatase activator activity" "hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP2R5D 1710.302413 1676.106765 1744.49806 1.040803663 0.057697944 0.810074377 1 29.91663461 30.61630162 5528 protein phosphatase 2 regulatory subunit B'delta "GO:0000159,GO:0004721,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006470,GO:0007165,GO:0007399,GO:0010801,GO:0019888,GO:0031952,GO:0035307,GO:0043666,GO:0072542" protein phosphatase type 2A complex|phosphoprotein phosphatase activity|protein binding|nucleus|nucleoplasm|cytosol|protein dephosphorylation|signal transduction|nervous system development|negative regulation of peptidyl-threonine phosphorylation|protein phosphatase regulator activity|regulation of protein autophosphorylation|positive regulation of protein dephosphorylation|regulation of phosphoprotein phosphatase activity|protein phosphatase activator activity "hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP2R5E 1425.454264 1540.85296 1310.055568 0.850214525 -0.234101188 0.328161391 1 8.947066752 7.479634504 5529 protein phosphatase 2 regulatory subunit B'epsilon "GO:0000159,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006470,GO:0007165,GO:0019888,GO:0031952,GO:0043666,GO:0072542" protein phosphatase type 2A complex|protein binding|nucleus|cytoplasm|cytosol|protein dephosphorylation|signal transduction|protein phosphatase regulator activity|regulation of protein autophosphorylation|regulation of phosphoprotein phosphatase activity|protein phosphatase activator activity "hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165" mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP3CA 1372.403831 1308.840664 1435.966998 1.097128961 0.133733116 0.578495284 1 14.42296525 15.55906213 5530 protein phosphatase 3 catalytic subunit alpha "GO:0000082,GO:0001975,GO:0004722,GO:0005509,GO:0005515,GO:0005516,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0005955,GO:0006470,GO:0006606,GO:0006816,GO:0007223,GO:0007420,GO:0007568,GO:0009898,GO:0014883,GO:0014898,GO:0016018,GO:0016311,GO:0019897,GO:0019899,GO:0030018,GO:0030335,GO:0033173,GO:0033192,GO:0033555,GO:0035562,GO:0036057,GO:0038095,GO:0042060,GO:0042110,GO:0042383,GO:0043197,GO:0043403,GO:0044877,GO:0045785,GO:0045807,GO:0045944,GO:0046676,GO:0046983,GO:0048741,GO:0050774,GO:0051091,GO:0051117,GO:0051592,GO:0060079,GO:0070262,GO:0071333,GO:0097720,GO:0098685,GO:0098978,GO:0099170,GO:0106306,GO:0106307,GO:1903244,GO:1903799,GO:1905205" "G1/S transition of mitotic cell cycle|response to amphetamine|protein serine/threonine phosphatase activity|calcium ion binding|protein binding|calmodulin binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|plasma membrane|calcineurin complex|protein dephosphorylation|protein import into nucleus|calcium ion transport|Wnt signaling pathway, calcium modulating pathway|brain development|aging|cytoplasmic side of plasma membrane|transition between fast and slow fiber|cardiac muscle hypertrophy in response to stress|cyclosporin A binding|dephosphorylation|extrinsic component of plasma membrane|enzyme binding|Z disc|positive regulation of cell migration|calcineurin-NFAT signaling cascade|calmodulin-dependent protein phosphatase activity|multicellular organismal response to stress|negative regulation of chromatin binding|slit diaphragm|Fc-epsilon receptor signaling pathway|wound healing|T cell activation|sarcolemma|dendritic spine|skeletal muscle tissue regeneration|protein-containing complex binding|positive regulation of cell adhesion|positive regulation of endocytosis|positive regulation of transcription by RNA polymerase II|negative regulation of insulin secretion|protein dimerization activity|skeletal muscle fiber development|negative regulation of dendrite morphogenesis|positive regulation of DNA-binding transcription factor activity|ATPase binding|response to calcium ion|excitatory postsynaptic potential|peptidyl-serine dephosphorylation|cellular response to glucose stimulus|calcineurin-mediated signaling|Schaffer collateral - CA1 synapse|glutamatergic synapse|postsynaptic modulation of chemical synaptic transmission|protein serine phosphatase activity|protein threonine phosphatase activity|positive regulation of cardiac muscle hypertrophy in response to stress|negative regulation of production of miRNAs involved in gene silencing by miRNA|positive regulation of connective tissue replacement" "hsa04010,hsa04020,hsa04022,hsa04114,hsa04218,hsa04310,hsa04360,hsa04370,hsa04380,hsa04625,hsa04650,hsa04658,hsa04659,hsa04660,hsa04662,hsa04720,hsa04724,hsa04728,hsa04921,hsa04922,hsa04924,hsa05010,hsa05014,hsa05020,hsa05022,hsa05031,hsa05152,hsa05163,hsa05166,hsa05167,hsa05170,hsa05235" MAPK signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Cellular senescence|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Long-term potentiation|Glutamatergic synapse|Dopaminergic synapse|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Alzheimer disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Tuberculosis|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer PPP3CB 1547.932451 1513.802199 1582.062704 1.04509209 0.063630073 0.791676445 1 17.45653438 17.93840262 5532 protein phosphatase 3 catalytic subunit beta "GO:0001915,GO:0001946,GO:0004722,GO:0005509,GO:0005515,GO:0005516,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005955,GO:0006468,GO:0006470,GO:0007165,GO:0007223,GO:0007507,GO:0007612,GO:0007613,GO:0016311,GO:0017156,GO:0019899,GO:0030018,GO:0030217,GO:0030315,GO:0030346,GO:0031987,GO:0033173,GO:0033192,GO:0034097,GO:0035774,GO:0038095,GO:0042098,GO:0042110,GO:0043029,GO:0045893,GO:0045944,GO:0046983,GO:0048167,GO:0048675,GO:0050796,GO:0097720,GO:0098978,GO:0106306,GO:0106307,GO:1900242" "negative regulation of T cell mediated cytotoxicity|lymphangiogenesis|protein serine/threonine phosphatase activity|calcium ion binding|protein binding|calmodulin binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|calcineurin complex|protein phosphorylation|protein dephosphorylation|signal transduction|Wnt signaling pathway, calcium modulating pathway|heart development|learning|memory|dephosphorylation|calcium-ion regulated exocytosis|enzyme binding|Z disc|T cell differentiation|T-tubule|protein phosphatase 2B binding|locomotion involved in locomotory behavior|calcineurin-NFAT signaling cascade|calmodulin-dependent protein phosphatase activity|response to cytokine|positive regulation of insulin secretion involved in cellular response to glucose stimulus|Fc-epsilon receptor signaling pathway|T cell proliferation|T cell activation|T cell homeostasis|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|regulation of synaptic plasticity|axon extension|regulation of insulin secretion|calcineurin-mediated signaling|glutamatergic synapse|protein serine phosphatase activity|protein threonine phosphatase activity|regulation of synaptic vesicle endocytosis" "hsa04010,hsa04020,hsa04022,hsa04114,hsa04218,hsa04310,hsa04360,hsa04370,hsa04380,hsa04625,hsa04650,hsa04658,hsa04659,hsa04660,hsa04662,hsa04720,hsa04724,hsa04728,hsa04921,hsa04922,hsa04924,hsa05010,hsa05014,hsa05020,hsa05022,hsa05031,hsa05152,hsa05163,hsa05166,hsa05167,hsa05170,hsa05235" MAPK signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Cellular senescence|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Long-term potentiation|Glutamatergic synapse|Dopaminergic synapse|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Alzheimer disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Tuberculosis|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer PPP3CC 465.4543062 460.90335 470.0052625 1.019747985 0.028212656 0.927345622 1 10.9517207 10.98111384 5533 protein phosphatase 3 catalytic subunit gamma "GO:0005515,GO:0005516,GO:0005737,GO:0005739,GO:0005829,GO:0005955,GO:0006470,GO:0007420,GO:0033173,GO:0033192,GO:0046872,GO:0097720,GO:0098793,GO:0098978,GO:0106306,GO:0106307,GO:1900244,GO:1900740" protein binding|calmodulin binding|cytoplasm|mitochondrion|cytosol|calcineurin complex|protein dephosphorylation|brain development|calcineurin-NFAT signaling cascade|calmodulin-dependent protein phosphatase activity|metal ion binding|calcineurin-mediated signaling|presynapse|glutamatergic synapse|protein serine phosphatase activity|protein threonine phosphatase activity|positive regulation of synaptic vesicle endocytosis|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway "hsa04010,hsa04020,hsa04022,hsa04114,hsa04218,hsa04310,hsa04360,hsa04370,hsa04380,hsa04625,hsa04650,hsa04658,hsa04659,hsa04660,hsa04662,hsa04720,hsa04724,hsa04728,hsa04921,hsa04922,hsa04924,hsa05010,hsa05014,hsa05020,hsa05022,hsa05031,hsa05152,hsa05163,hsa05166,hsa05167,hsa05170,hsa05235" MAPK signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Cellular senescence|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Long-term potentiation|Glutamatergic synapse|Dopaminergic synapse|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Alzheimer disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Tuberculosis|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer PPP3R1 1716.069348 1676.106765 1756.031932 1.047685009 0.06720503 0.779052806 1 29.58027033 30.47221663 5534 "protein phosphatase 3 regulatory subunit B, alpha" "GO:0004723,GO:0005509,GO:0005515,GO:0005516,GO:0005654,GO:0005739,GO:0005829,GO:0005955,GO:0006470,GO:0007223,GO:0008597,GO:0016018,GO:0019902,GO:0019904,GO:0033173,GO:0038095,GO:0042383,GO:0043666,GO:0045944,GO:1900740" "calcium-dependent protein serine/threonine phosphatase activity|calcium ion binding|protein binding|calmodulin binding|nucleoplasm|mitochondrion|cytosol|calcineurin complex|protein dephosphorylation|Wnt signaling pathway, calcium modulating pathway|calcium-dependent protein serine/threonine phosphatase regulator activity|cyclosporin A binding|phosphatase binding|protein domain specific binding|calcineurin-NFAT signaling cascade|Fc-epsilon receptor signaling pathway|sarcolemma|regulation of phosphoprotein phosphatase activity|positive regulation of transcription by RNA polymerase II|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" "hsa04010,hsa04020,hsa04022,hsa04114,hsa04218,hsa04310,hsa04360,hsa04370,hsa04380,hsa04625,hsa04650,hsa04658,hsa04659,hsa04660,hsa04662,hsa04720,hsa04724,hsa04921,hsa04922,hsa04924,hsa05010,hsa05014,hsa05020,hsa05022,hsa05031,hsa05152,hsa05163,hsa05166,hsa05167,hsa05170,hsa05235" MAPK signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Cellular senescence|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Long-term potentiation|Glutamatergic synapse|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Alzheimer disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Tuberculosis|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer PPP4C 2256.761775 2068.342799 2445.180752 1.182193181 0.241465804 0.307181017 1 75.1932246 87.40541477 5531 protein phosphatase 4 catalytic subunit "GO:0004704,GO:0004722,GO:0005515,GO:0005654,GO:0005815,GO:0005829,GO:0005886,GO:0006470,GO:0010569,GO:0030289,GO:0038061,GO:0046872,GO:0106306,GO:0106307" NF-kappaB-inducing kinase activity|protein serine/threonine phosphatase activity|protein binding|nucleoplasm|microtubule organizing center|cytosol|plasma membrane|protein dephosphorylation|regulation of double-strand break repair via homologous recombination|protein phosphatase 4 complex|NIK/NF-kappaB signaling|metal ion binding|protein serine phosphatase activity|protein threonine phosphatase activity hsa04922 Glucagon signaling pathway PPP4R1 2601.833813 2523.003665 2680.663961 1.062489127 0.087448077 0.712516697 1 32.42968895 33.87961419 9989 protein phosphatase 4 regulatory subunit 1 "GO:0004721,GO:0004722,GO:0005515,GO:0006468,GO:0006470,GO:0007165,GO:0008287,GO:0019888,GO:0030289,GO:0043666" phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein binding|protein phosphorylation|protein dephosphorylation|signal transduction|protein serine/threonine phosphatase complex|protein phosphatase regulator activity|protein phosphatase 4 complex|regulation of phosphoprotein phosphatase activity PPP4R2 1503.387154 1542.933788 1463.840521 0.948738392 -0.075917766 0.752436498 1 15.25728006 14.23294503 151987 protein phosphatase 4 regulatory subunit 2 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0006397,GO:0006464,GO:0006470,GO:0008380,GO:0010569,GO:0019888,GO:0030289,GO:0030674,GO:0043666" protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|mRNA processing|cellular protein modification process|protein dephosphorylation|RNA splicing|regulation of double-strand break repair via homologous recombination|protein phosphatase regulator activity|protein phosphatase 4 complex|protein-macromolecule adaptor activity|regulation of phosphoprotein phosphatase activity PPP4R3A 1063.458201 1045.615952 1081.30045 1.03412773 0.04841439 0.846592304 1 14.54708071 14.79180628 55671 protein phosphatase 4 regulatory subunit 3A "GO:0005654,GO:0005815,GO:0005829,GO:0016607" nucleoplasm|microtubule organizing center|cytosol|nuclear speck hsa04922 Glucagon signaling pathway PPP4R3B 1804.632862 1932.04858 1677.217143 0.868102987 -0.204061889 0.389729997 1 17.71038849 15.11717069 57223 protein phosphatase 4 regulatory subunit 3B "GO:0005654,GO:0005737,GO:0005813,GO:0006470,GO:0016607,GO:0019216,GO:0030289,GO:0045722" nucleoplasm|cytoplasm|centrosome|protein dephosphorylation|nuclear speck|regulation of lipid metabolic process|protein phosphatase 4 complex|positive regulation of gluconeogenesis hsa04922 Glucagon signaling pathway PPP4R4 1051.419214 1007.120638 1095.71779 1.087970744 0.121639762 0.621348028 1 11.07753039 11.85035459 57718 protein phosphatase 4 regulatory subunit 4 "GO:0001835,GO:0005515,GO:0005737,GO:0005829,GO:0008287,GO:0019888,GO:0032515,GO:0080163" blastocyst hatching|protein binding|cytoplasm|cytosol|protein serine/threonine phosphatase complex|protein phosphatase regulator activity|negative regulation of phosphoprotein phosphatase activity|regulation of protein serine/threonine phosphatase activity PPP5C 1239.140921 1166.303962 1311.97788 1.124902189 0.169799563 0.483137552 1 28.85651317 31.91756805 5536 protein phosphatase 5 catalytic subunit "GO:0000165,GO:0000278,GO:0001933,GO:0001965,GO:0003723,GO:0004721,GO:0004722,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006281,GO:0006351,GO:0006470,GO:0008017,GO:0008289,GO:0010288,GO:0016576,GO:0016791,GO:0032991,GO:0035970,GO:0042802,GO:0043123,GO:0043204,GO:0043231,GO:0043278,GO:0043531,GO:0044877,GO:0046872,GO:0048156,GO:0051879,GO:0070262,GO:0070301,GO:0071276,GO:0101031,GO:0106306,GO:0106307,GO:1901215,GO:1904550,GO:1990635,GO:2000324" "MAPK cascade|mitotic cell cycle|negative regulation of protein phosphorylation|G-protein alpha-subunit binding|RNA binding|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|DNA repair|transcription, DNA-templated|protein dephosphorylation|microtubule binding|lipid binding|response to lead ion|histone dephosphorylation|phosphatase activity|protein-containing complex|peptidyl-threonine dephosphorylation|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|perikaryon|intracellular membrane-bounded organelle|response to morphine|ADP binding|protein-containing complex binding|metal ion binding|tau protein binding|Hsp90 protein binding|peptidyl-serine dephosphorylation|cellular response to hydrogen peroxide|cellular response to cadmium ion|chaperone complex|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of neuron death|response to arachidonic acid|proximal dendrite|positive regulation of glucocorticoid receptor signaling pathway" hsa04010 MAPK signaling pathway PPP6C 1728.449905 1761.420703 1695.479106 0.962563403 -0.055046522 0.818671598 1 19.93717616 18.86966415 5537 protein phosphatase 6 catalytic subunit "GO:0000082,GO:0000139,GO:0004722,GO:0005515,GO:0005739,GO:0005829,GO:0006470,GO:0045087,GO:0046872,GO:0048208,GO:0106306,GO:0106307" G1/S transition of mitotic cell cycle|Golgi membrane|protein serine/threonine phosphatase activity|protein binding|mitochondrion|cytosol|protein dephosphorylation|innate immune response|metal ion binding|COPII vesicle coating|protein serine phosphatase activity|protein threonine phosphatase activity PPP6R1 2147.155398 2054.817418 2239.493377 1.089874632 0.124162192 0.600416457 1 27.52555949 29.49740954 22870 protein phosphatase 6 regulatory subunit 1 "GO:0000139,GO:0005515,GO:0005634,GO:0005829,GO:0019888,GO:0019903,GO:0031267,GO:0043666,GO:0048208" Golgi membrane|protein binding|nucleus|cytosol|protein phosphatase regulator activity|protein phosphatase binding|small GTPase binding|regulation of phosphoprotein phosphatase activity|COPII vesicle coating PPP6R2 991.4457321 1060.181746 922.7097178 0.87033164 -0.20036285 0.416322933 1 12.03828751 10.30197904 9701 protein phosphatase 6 regulatory subunit 2 "GO:0005515,GO:0005634,GO:0005829,GO:0019888,GO:0019903,GO:0043231,GO:0043666" protein binding|nucleus|cytosol|protein phosphatase regulator activity|protein phosphatase binding|intracellular membrane-bounded organelle|regulation of phosphoprotein phosphatase activity PPP6R3 3309.888222 3410.476707 3209.299737 0.941012067 -0.087714871 0.712170672 1 19.00698347 17.58650615 55291 protein phosphatase 6 regulatory subunit 3 "GO:0000139,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0019888,GO:0019903,GO:0043666,GO:0048208" Golgi membrane|protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|protein phosphatase regulator activity|protein phosphatase binding|regulation of phosphoprotein phosphatase activity|COPII vesicle coating PPRC1 2263.199946 2489.710421 2036.689471 0.818042714 -0.289751919 0.220295476 1 20.30739252 16.33432991 23082 PPARG related coactivator 1 "GO:0003723,GO:0005634,GO:0005654,GO:0007005,GO:0008134,GO:0030374,GO:0045944,GO:0051091" RNA binding|nucleus|nucleoplasm|mitochondrion organization|transcription factor binding|nuclear receptor coactivator activity|positive regulation of transcription by RNA polymerase II|positive regulation of DNA-binding transcription factor activity PPT1 2146.445264 2326.365442 1966.525086 0.845320796 -0.242429153 0.305324394 1 35.12131483 29.19197631 5538 palmitoyl-protein thioesterase 1 "GO:0002084,GO:0005515,GO:0005576,GO:0005634,GO:0005764,GO:0005794,GO:0005829,GO:0006898,GO:0006907,GO:0007042,GO:0007399,GO:0007420,GO:0007601,GO:0008021,GO:0008474,GO:0015031,GO:0016020,GO:0016042,GO:0016290,GO:0016790,GO:0018215,GO:0030149,GO:0030163,GO:0030308,GO:0030424,GO:0031579,GO:0035727,GO:0043066,GO:0043202,GO:0043231,GO:0043524,GO:0045121,GO:0046949,GO:0048260,GO:0048549,GO:0048666,GO:0050803,GO:0050896,GO:0070062,GO:0120146" protein depalmitoylation|protein binding|extracellular region|nucleus|lysosome|Golgi apparatus|cytosol|receptor-mediated endocytosis|pinocytosis|lysosomal lumen acidification|nervous system development|brain development|visual perception|synaptic vesicle|palmitoyl-(protein) hydrolase activity|protein transport|membrane|lipid catabolic process|palmitoyl-CoA hydrolase activity|thiolester hydrolase activity|protein phosphopantetheinylation|sphingolipid catabolic process|protein catabolic process|negative regulation of cell growth|axon|membrane raft organization|lysophosphatidic acid binding|negative regulation of apoptotic process|lysosomal lumen|intracellular membrane-bounded organelle|negative regulation of neuron apoptotic process|membrane raft|fatty-acyl-CoA biosynthetic process|positive regulation of receptor-mediated endocytosis|positive regulation of pinocytosis|neuron development|regulation of synapse structure or activity|response to stimulus|extracellular exosome|sulfatide binding "hsa00062,hsa04142" Fatty acid elongation|Lysosome PPT2 411.7635509 426.5696919 396.9574098 0.930580436 -0.103797238 0.723812997 1 11.35423464 10.38922044 9374 palmitoyl-protein thioesterase 2 "GO:0005764,GO:0008474,GO:0016790,GO:0018215,GO:0043202,GO:0043231,GO:0046949,GO:0070062,GO:0098599,GO:0098734" lysosome|palmitoyl-(protein) hydrolase activity|thiolester hydrolase activity|protein phosphopantetheinylation|lysosomal lumen|intracellular membrane-bounded organelle|fatty-acyl-CoA biosynthetic process|extracellular exosome|palmitoyl hydrolase activity|macromolecule depalmitoylation "hsa00062,hsa04142" Fatty acid elongation|Lysosome PPTC7 950.6016344 1047.69678 853.5064889 0.814650293 -0.295747212 0.231229113 1 11.79612902 9.448914316 160760 protein phosphatase targeting COQ7 "GO:0004722,GO:0005515,GO:0005739,GO:0005759,GO:0010795,GO:0046872,GO:0070262,GO:0106306,GO:0106307" protein serine/threonine phosphatase activity|protein binding|mitochondrion|mitochondrial matrix|regulation of ubiquinone biosynthetic process|metal ion binding|peptidyl-serine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity PPWD1 753.5369384 718.9259929 788.1478839 1.096285142 0.132623089 0.603806548 1 17.25169016 18.59629197 23398 peptidylprolyl isomerase domain and WD repeat containing 1 "GO:0000398,GO:0000413,GO:0003755,GO:0005654,GO:0016018,GO:0016604,GO:0071013" "mRNA splicing, via spliceosome|protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|nucleoplasm|cyclosporin A binding|nuclear body|catalytic step 2 spliceosome" PPY 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.21917754 0.265456697 5539 pancreatic polypeptide "GO:0001664,GO:0005179,GO:0005184,GO:0005515,GO:0005576,GO:0005615,GO:0007186,GO:0007218,GO:0007631,GO:0009306,GO:0031841" G protein-coupled receptor binding|hormone activity|neuropeptide hormone activity|protein binding|extracellular region|extracellular space|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|feeding behavior|protein secretion|neuropeptide Y receptor binding hsa04080 Neuroactive ligand-receptor interaction PQBP1 1017.259163 905.1600779 1129.358248 1.247688973 0.319258341 0.193487601 1 38.43017482 47.14654537 10084 polyglutamine binding protein 1 "GO:0000380,GO:0000398,GO:0002218,GO:0002230,GO:0003677,GO:0003690,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0010494,GO:0016604,GO:0016607,GO:0031175,GO:0032481,GO:0043021,GO:0043484,GO:0045087,GO:0045893,GO:0048814,GO:0051607,GO:0071360,GO:0071598" "alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|activation of innate immune response|positive regulation of defense response to virus by host|DNA binding|double-stranded DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|cytoplasmic stress granule|nuclear body|nuclear speck|neuron projection development|positive regulation of type I interferon production|ribonucleoprotein complex binding|regulation of RNA splicing|innate immune response|positive regulation of transcription, DNA-templated|regulation of dendrite morphogenesis|defense response to virus|cellular response to exogenous dsRNA|neuronal ribonucleoprotein granule" hsa03040 Spliceosome PRADC1 224.830007 199.7594655 249.9005486 1.251007295 0.323090202 0.355750336 1 9.780546357 12.03078974 84279 protease associated domain containing 1 "GO:0005515,GO:0005576" protein binding|extracellular region PRAF2 1071.622996 1058.100919 1085.145074 1.025559146 0.036410697 0.885306483 1 44.81658835 45.1929492 11230 PRA1 domain family member 2 "GO:0005515,GO:0010008,GO:0015031,GO:0015813,GO:0016020,GO:0016021" protein binding|endosome membrane|protein transport|L-glutamate transmembrane transport|membrane|integral component of membrane PRAG1 245.4942457 300.6796121 190.3088793 0.63292911 -0.659884172 0.050103697 1 2.952478063 1.837438993 157285 "PEAK1 related, kinase-activating pseudokinase 1" "GO:0004672,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005925,GO:0006468,GO:0008360,GO:0008593,GO:0010977,GO:0016477,GO:0035025,GO:0042802,GO:2000145" protein kinase activity|protein binding|ATP binding|nucleus|cytoplasm|focal adhesion|protein phosphorylation|regulation of cell shape|regulation of Notch signaling pathway|negative regulation of neuron projection development|cell migration|positive regulation of Rho protein signal transduction|identical protein binding|regulation of cell motility PRB3 5.003924597 5.202069413 4.80577978 0.923820772 -0.11431511 1 1 0.252157024 0.229049829 5544 proline rich protein BstNI subfamily 3 "GO:0005515,GO:0005576,GO:0008150,GO:0050829" protein binding|extracellular region|biological_process|defense response to Gram-negative bacterium PRC1 4863.305791 4828.560829 4898.050752 1.014391436 0.02061447 0.932360962 1 83.77484296 83.55844992 9055 protein regulator of cytokinesis 1 "GO:0000022,GO:0000226,GO:0000922,GO:0001578,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005819,GO:0005829,GO:0005876,GO:0005886,GO:0008017,GO:0008284,GO:0015630,GO:0019894,GO:0019901,GO:0030496,GO:0032465,GO:0045171,GO:0051256,GO:0051301,GO:0070938,GO:1990023" mitotic spindle elongation|microtubule cytoskeleton organization|spindle pole|microtubule bundle formation|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|spindle|cytosol|spindle microtubule|plasma membrane|microtubule binding|positive regulation of cell population proliferation|microtubule cytoskeleton|kinesin binding|protein kinase binding|midbody|regulation of cytokinesis|intercellular bridge|mitotic spindle midzone assembly|cell division|contractile ring|mitotic spindle midzone PRCC 1079.65823 1193.354723 965.9617358 0.809450633 -0.304985 0.211702344 1 24.47622917 19.48076719 5546 proline rich mitotic checkpoint control factor "GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0007093,GO:0016607" "mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|mitotic cell cycle checkpoint|nuclear speck" "hsa05202,hsa05211" Transcriptional misregulation in cancer|Renal cell carcinoma PRCD 3.884252787 1.040413883 6.728091692 6.466745402 2.693039812 0.222326747 1 0.008775877 0.055801708 768206 photoreceptor disc component "GO:0002046,GO:0005576,GO:0005737,GO:0005783,GO:0005794,GO:0007601,GO:0042622,GO:0050896" opsin binding|extracellular region|cytoplasm|endoplasmic reticulum|Golgi apparatus|visual perception|photoreceptor outer segment membrane|response to stimulus PRCP 2493.813823 2349.254547 2638.373099 1.12306821 0.167445553 0.479166832 1 34.34001573 37.92082721 5547 prolylcarboxypeptidase "GO:0002155,GO:0002353,GO:0003085,GO:0004185,GO:0005515,GO:0005886,GO:0006508,GO:0007597,GO:0008239,GO:0035577,GO:0042593,GO:0043231,GO:0043312,GO:0043535,GO:0045178,GO:0060055,GO:0070062,GO:0097009,GO:0101003,GO:2000377" "regulation of thyroid hormone mediated signaling pathway|plasma kallikrein-kinin cascade|negative regulation of systemic arterial blood pressure|serine-type carboxypeptidase activity|protein binding|plasma membrane|proteolysis|blood coagulation, intrinsic pathway|dipeptidyl-peptidase activity|azurophil granule membrane|glucose homeostasis|intracellular membrane-bounded organelle|neutrophil degranulation|regulation of blood vessel endothelial cell migration|basal part of cell|angiogenesis involved in wound healing|extracellular exosome|energy homeostasis|ficolin-1-rich granule membrane|regulation of reactive oxygen species metabolic process" "hsa04614,hsa04974" Renin-angiotensin system|Protein digestion and absorption PRDM1 7.005494435 7.282897178 6.728091692 0.923820772 -0.11431511 1 1 0.046171874 0.041940771 639 PR/SET domain 1 "GO:0000122,GO:0000978,GO:0001227,GO:0002250,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0008168,GO:0010468,GO:0032259,GO:0032823,GO:0033082,GO:0042826,GO:0045087,GO:0045165,GO:0046872,GO:0051136,GO:1990837,GO:1990841" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|adaptive immune response|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|methyltransferase activity|regulation of gene expression|methylation|regulation of natural killer cell differentiation|regulation of extrathymic T cell differentiation|histone deacetylase binding|innate immune response|cell fate commitment|metal ion binding|regulation of NK T cell differentiation|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding" zf-C2H2 PRDM10 400.5221734 396.3976893 404.6466575 1.020809829 0.029714126 0.927272334 1 3.186476296 3.198355349 56980 PR/SET domain 10 "GO:0000785,GO:0003677,GO:0005515,GO:0005634,GO:0008168,GO:0010468,GO:0017053,GO:0032259,GO:0045944,GO:0046872" chromatin|DNA binding|protein binding|nucleus|methyltransferase activity|regulation of gene expression|transcription repressor complex|methylation|positive regulation of transcription by RNA polymerase II|metal ion binding PRDM11 97.67057162 116.5263549 78.81478839 0.676368779 -0.564118027 0.232874492 1 0.433154377 0.288069606 56981 PR/SET domain 11 "GO:0003682,GO:0005515,GO:0005634,GO:0005829,GO:0008168,GO:0010468,GO:0030308,GO:0032259,GO:0043408,GO:0045892,GO:0045893,GO:0051726,GO:2000271" "chromatin binding|protein binding|nucleus|cytosol|methyltransferase activity|regulation of gene expression|negative regulation of cell growth|methylation|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|regulation of cell cycle|positive regulation of fibroblast apoptotic process" PRDM12 5.04355356 6.242483296 3.844623824 0.615880514 -0.699277611 0.760739355 1 0.134443043 0.08141529 59335 PR/SET domain 12 "GO:0000122,GO:0003677,GO:0005634,GO:0005654,GO:0008168,GO:0010468,GO:0019233,GO:0022008,GO:0031175,GO:0032259,GO:0046872,GO:0050965,GO:0051574,GO:1900111,GO:1990226" negative regulation of transcription by RNA polymerase II|DNA binding|nucleus|nucleoplasm|methyltransferase activity|regulation of gene expression|sensory perception of pain|neurogenesis|neuron projection development|methylation|metal ion binding|detection of temperature stimulus involved in sensory perception of pain|positive regulation of histone H3-K9 methylation|positive regulation of histone H3-K9 dimethylation|histone methyltransferase binding PRDM15 212.2010014 234.0931236 190.3088793 0.812962279 -0.298739681 0.403849111 1 1.052938876 0.841675594 63977 PR/SET domain 15 "GO:0000978,GO:0001228,GO:0005634,GO:0005654,GO:0006357,GO:0007275,GO:0008168,GO:0016604,GO:0032259,GO:0043409,GO:0045944,GO:0046872,GO:0090263,GO:1990841,GO:2000035" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|multicellular organism development|methyltransferase activity|nuclear body|methylation|negative regulation of MAPK cascade|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of canonical Wnt signaling pathway|promoter-specific chromatin binding|regulation of stem cell division" PRDM2 570.5316924 582.6317743 558.4316104 0.958464051 -0.061203773 0.823641831 1 2.648325267 2.495849139 7799 PR/SET domain 2 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0001228,GO:0003700,GO:0005634,GO:0005654,GO:0005794,GO:0006355,GO:0006357,GO:0008168,GO:0008270,GO:0008340,GO:0010468,GO:0032259,GO:0043565,GO:0045944" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|Golgi apparatus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|methyltransferase activity|zinc ion binding|determination of adult lifespan|regulation of gene expression|methylation|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II" hsa00310 Lysine degradation PRDM4 1445.956185 1448.256125 1443.656246 0.99682385 -0.004589508 0.987963011 1 17.79663081 17.44324939 11108 PR/SET domain 4 "GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005737,GO:0006366,GO:0008168,GO:0010468,GO:0035097,GO:0043985,GO:0045944,GO:0046872,GO:1990226,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|cytoplasm|transcription by RNA polymerase II|methyltransferase activity|regulation of gene expression|histone methyltransferase complex|histone H4-R3 methylation|positive regulation of transcription by RNA polymerase II|metal ion binding|histone methyltransferase binding|sequence-specific double-stranded DNA binding" hsa04722 Neurotrophin signaling pathway PRDM5 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.025060167 0.0227637 11107 PR/SET domain 5 "GO:0000122,GO:0000278,GO:0000976,GO:0000977,GO:0000978,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0008168,GO:0010468,GO:0016575,GO:0016604,GO:0043565,GO:0045892,GO:0046872,GO:0051567,GO:0070491,GO:1990830" "negative regulation of transcription by RNA polymerase II|mitotic cell cycle|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|methyltransferase activity|regulation of gene expression|histone deacetylation|nuclear body|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding|histone H3-K9 methylation|repressing transcription factor binding|cellular response to leukemia inhibitory factor" PRDM6 8.848548421 5.202069413 12.49502743 2.401934007 1.264196513 0.321680077 1 0.02723949 0.064332618 93166 PR/SET domain 6 "GO:0000122,GO:0005515,GO:0005634,GO:0006325,GO:0008168,GO:0010468,GO:0022008,GO:0032259,GO:0042802,GO:0046872,GO:0051151" negative regulation of transcription by RNA polymerase II|protein binding|nucleus|chromatin organization|methyltransferase activity|regulation of gene expression|neurogenesis|methylation|identical protein binding|metal ion binding|negative regulation of smooth muscle cell differentiation hsa00310 Lysine degradation zf-C2H2 PRDM8 438.3047801 353.7407201 522.8688401 1.478113235 0.563756795 0.045860938 1 3.420016682 4.970580465 56978 PR/SET domain 8 "GO:0003677,GO:0005515,GO:0005634,GO:0006355,GO:0008168,GO:0014003,GO:0032259,GO:0046872" "DNA binding|protein binding|nucleus|regulation of transcription, DNA-templated|methyltransferase activity|oligodendrocyte development|methylation|metal ion binding" PRDX1 7751.477832 6869.852867 8633.102797 1.256664875 0.329599966 0.180729595 1 286.8790464 354.4781607 5052 peroxiredoxin 1 "GO:0001501,GO:0001895,GO:0003723,GO:0004601,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0006979,GO:0008283,GO:0008379,GO:0019430,GO:0030101,GO:0033554,GO:0034599,GO:0042470,GO:0042744,GO:0045296,GO:0045321,GO:0045454,GO:0055114,GO:0070062" skeletal system development|retina homeostasis|RNA binding|peroxidase activity|protein binding|extracellular space|nucleus|cytoplasm|cytosol|response to oxidative stress|cell population proliferation|thioredoxin peroxidase activity|removal of superoxide radicals|natural killer cell activation|cellular response to stress|cellular response to oxidative stress|melanosome|hydrogen peroxide catabolic process|cadherin binding|leukocyte activation|cell redox homeostasis|oxidation-reduction process|extracellular exosome "hsa04146,hsa05146" Peroxisome|Amoebiasis PRDX2 1998.574357 1762.461117 2234.687598 1.267935829 0.342481732 0.147872354 1 101.6857411 126.7735089 7001 peroxiredoxin 2 "GO:0000187,GO:0002536,GO:0005515,GO:0005737,GO:0005829,GO:0006979,GO:0008379,GO:0010310,GO:0016209,GO:0019430,GO:0030194,GO:0031665,GO:0032088,GO:0032496,GO:0033554,GO:0034599,GO:0042098,GO:0042744,GO:0042981,GO:0043066,GO:0045321,GO:0045454,GO:0045581,GO:0048538,GO:0048872,GO:0055114,GO:0070062,GO:2001240" activation of MAPK activity|respiratory burst involved in inflammatory response|protein binding|cytoplasm|cytosol|response to oxidative stress|thioredoxin peroxidase activity|regulation of hydrogen peroxide metabolic process|antioxidant activity|removal of superoxide radicals|positive regulation of blood coagulation|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|response to lipopolysaccharide|cellular response to stress|cellular response to oxidative stress|T cell proliferation|hydrogen peroxide catabolic process|regulation of apoptotic process|negative regulation of apoptotic process|leukocyte activation|cell redox homeostasis|negative regulation of T cell differentiation|thymus development|homeostasis of number of cells|oxidation-reduction process|extracellular exosome|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand PRDX3 2403.263217 2154.697151 2651.829283 1.230720188 0.299502793 0.205195993 1 74.04522008 89.60402765 10935 peroxiredoxin 3 "GO:0001893,GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0005769,GO:0005829,GO:0006915,GO:0006979,GO:0007005,GO:0008022,GO:0008284,GO:0008379,GO:0008785,GO:0018171,GO:0019900,GO:0019901,GO:0030099,GO:0032496,GO:0032991,GO:0033673,GO:0034599,GO:0034614,GO:0042542,GO:0042744,GO:0042802,GO:0043027,GO:0043066,GO:0043154,GO:0045454,GO:0051092,GO:0051881,GO:0098869" maternal placenta development|protein binding|cytoplasm|mitochondrion|mitochondrial matrix|early endosome|cytosol|apoptotic process|response to oxidative stress|mitochondrion organization|protein C-terminus binding|positive regulation of cell population proliferation|thioredoxin peroxidase activity|alkyl hydroperoxide reductase activity|peptidyl-cysteine oxidation|kinase binding|protein kinase binding|myeloid cell differentiation|response to lipopolysaccharide|protein-containing complex|negative regulation of kinase activity|cellular response to oxidative stress|cellular response to reactive oxygen species|response to hydrogen peroxide|hydrogen peroxide catabolic process|identical protein binding|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|cell redox homeostasis|positive regulation of NF-kappaB transcription factor activity|regulation of mitochondrial membrane potential|cellular oxidant detoxification PRDX4 2064.462001 1940.371891 2188.552112 1.12790343 0.173643551 0.463402806 1 108.320169 120.1302622 10549 peroxiredoxin 4 "GO:0005515,GO:0005576,GO:0005634,GO:0005783,GO:0005790,GO:0005829,GO:0006979,GO:0007252,GO:0007283,GO:0008379,GO:0008584,GO:0018401,GO:0022417,GO:0030198,GO:0033554,GO:0034774,GO:0042744,GO:0043312,GO:0045454,GO:0055114,GO:0070062,GO:0072593,GO:0098869,GO:1904813,GO:2000255" protein binding|extracellular region|nucleus|endoplasmic reticulum|smooth endoplasmic reticulum|cytosol|response to oxidative stress|I-kappaB phosphorylation|spermatogenesis|thioredoxin peroxidase activity|male gonad development|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|protein maturation by protein folding|extracellular matrix organization|cellular response to stress|secretory granule lumen|hydrogen peroxide catabolic process|neutrophil degranulation|cell redox homeostasis|oxidation-reduction process|extracellular exosome|reactive oxygen species metabolic process|cellular oxidant detoxification|ficolin-1-rich granule lumen|negative regulation of male germ cell proliferation PRDX5 4534.158221 4211.595397 4856.721046 1.153178449 0.20561578 0.389959307 1 261.3547741 296.3453613 25824 peroxiredoxin 5 "GO:0001016,GO:0004601,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0005782,GO:0005829,GO:0006915,GO:0006954,GO:0006979,GO:0008379,GO:0016480,GO:0031410,GO:0034599,GO:0034614,GO:0042744,GO:0043027,GO:0043066,GO:0043154,GO:0043231,GO:0045454,GO:0048471,GO:0055114,GO:0070062,GO:0098869" RNA polymerase III transcription regulatory region sequence-specific DNA binding|peroxidase activity|protein binding|extracellular space|nucleus|cytoplasm|mitochondrion|mitochondrial matrix|peroxisome|peroxisomal matrix|cytosol|apoptotic process|inflammatory response|response to oxidative stress|thioredoxin peroxidase activity|negative regulation of transcription by RNA polymerase III|cytoplasmic vesicle|cellular response to oxidative stress|cellular response to reactive oxygen species|hydrogen peroxide catabolic process|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|intracellular membrane-bounded organelle|cell redox homeostasis|perinuclear region of cytoplasm|oxidation-reduction process|extracellular exosome|cellular oxidant detoxification hsa04146 Peroxisome PRDX6 4461.60358 4577.821084 4345.386077 0.949225843 -0.075176716 0.753688423 1 144.5620696 134.9258271 9588 peroxiredoxin 6 "GO:0004602,GO:0004623,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006979,GO:0016020,GO:0031625,GO:0034599,GO:0035578,GO:0042744,GO:0042802,GO:0043312,GO:0045296,GO:0045454,GO:0046475,GO:0047184,GO:0047499,GO:0048026,GO:0048471,GO:0051920,GO:0055114,GO:0070062,GO:0098869,GO:0102567,GO:0102568" "glutathione peroxidase activity|phospholipase A2 activity|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|mitochondrion|cytosol|response to oxidative stress|membrane|ubiquitin protein ligase binding|cellular response to oxidative stress|azurophil granule lumen|hydrogen peroxide catabolic process|identical protein binding|neutrophil degranulation|cadherin binding|cell redox homeostasis|glycerophospholipid catabolic process|1-acylglycerophosphocholine O-acyltransferase activity|calcium-independent phospholipase A2 activity|positive regulation of mRNA splicing, via spliceosome|perinuclear region of cytoplasm|peroxiredoxin activity|oxidation-reduction process|extracellular exosome|cellular oxidant detoxification|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)" hsa00480 Glutathione metabolism PREB 845.5795829 788.633723 902.5254427 1.144416497 0.1946122 0.437690004 1 19.78746232 22.26616326 10113 prolactin regulatory element binding "GO:0000139,GO:0003400,GO:0003677,GO:0005085,GO:0005096,GO:0005515,GO:0005634,GO:0005789,GO:0006888,GO:0009306,GO:0016020,GO:0030176,GO:0032527,GO:0036498,GO:0043547,GO:0048208,GO:0051020,GO:0070971" Golgi membrane|regulation of COPII vesicle coating|DNA binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|nucleus|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|protein secretion|membrane|integral component of endoplasmic reticulum membrane|protein exit from endoplasmic reticulum|IRE1-mediated unfolded protein response|positive regulation of GTPase activity|COPII vesicle coating|GTPase binding|endoplasmic reticulum exit site hsa04141 Protein processing in endoplasmic reticulum PRELID1 2141.086522 2009.039207 2273.133836 1.131453198 0.178176909 0.451598314 1 87.45410281 97.29442629 27166 PRELI domain containing 1 "GO:0005515,GO:0005654,GO:0005739,GO:0005758,GO:0006915,GO:0006955,GO:0007275,GO:0010917,GO:0010950,GO:0015914,GO:0032991,GO:0042981,GO:0043066,GO:0045580,GO:0051881,GO:0070234,GO:0090201,GO:0097035,GO:0120009,GO:1901857,GO:1990050,GO:2001140" protein binding|nucleoplasm|mitochondrion|mitochondrial intermembrane space|apoptotic process|immune response|multicellular organism development|negative regulation of mitochondrial membrane potential|positive regulation of endopeptidase activity|phospholipid transport|protein-containing complex|regulation of apoptotic process|negative regulation of apoptotic process|regulation of T cell differentiation|regulation of mitochondrial membrane potential|positive regulation of T cell apoptotic process|negative regulation of release of cytochrome c from mitochondria|regulation of membrane lipid distribution|intermembrane lipid transfer|positive regulation of cellular respiration|phosphatidic acid transfer activity|positive regulation of phospholipid transport PRELID2 323.4466433 353.7407201 293.1525666 0.828721575 -0.271040614 0.38014454 1 1.236636452 1.007678211 153768 PRELI domain containing 2 "GO:0005758,GO:0015914,GO:0120009,GO:1990050" mitochondrial intermembrane space|phospholipid transport|intermembrane lipid transfer|phosphatidic acid transfer activity PRELID3A 85.38374985 96.75849109 74.00900861 0.764883865 -0.38668738 0.441227918 1 2.123282416 1.596887941 10650 PRELI domain containing 3A "GO:0005515,GO:0005758,GO:0015914,GO:0120009,GO:1990050" protein binding|mitochondrial intermembrane space|phospholipid transport|intermembrane lipid transfer|phosphatidic acid transfer activity PRELID3B 3452.754474 3275.222903 3630.286046 1.108408848 0.148490133 0.53181843 1 69.83325078 76.10854543 51012 PRELI domain containing 3B "GO:0005758,GO:0015914,GO:0120009,GO:1990050" mitochondrial intermembrane space|phospholipid transport|intermembrane lipid transfer|phosphatidic acid transfer activity PRELP 10.61234448 1.040413883 20.18427508 19.40023621 4.278002313 0.003505094 0.377418567 0.009641427 0.183915996 5549 proline and arginine rich end leucine rich repeat protein "GO:0001501,GO:0005201,GO:0005576,GO:0005615,GO:0005796,GO:0007569,GO:0008201,GO:0018146,GO:0030021,GO:0031012,GO:0042340,GO:0043202,GO:0062023,GO:0070062,GO:1903561" skeletal system development|extracellular matrix structural constituent|extracellular region|extracellular space|Golgi lumen|cell aging|heparin binding|keratan sulfate biosynthetic process|extracellular matrix structural constituent conferring compression resistance|extracellular matrix|keratan sulfate catabolic process|lysosomal lumen|collagen-containing extracellular matrix|extracellular exosome|extracellular vesicle PREP 1071.147449 1045.615952 1096.678946 1.048835324 0.06878818 0.781449258 1 4.498033339 4.638751996 5550 prolyl endopeptidase "GO:0004175,GO:0004252,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0008236,GO:0016020,GO:0070012" endopeptidase activity|serine-type endopeptidase activity|protein binding|nucleus|cytoplasm|cytosol|proteolysis|serine-type peptidase activity|membrane|oligopeptidase activity hsa04614 Renin-angiotensin system PREPL 2204.184433 2252.496056 2155.872809 0.957103922 -0.063252514 0.790544401 1 16.30871993 15.34794199 9581 prolyl endopeptidase like "GO:0004252,GO:0005634,GO:0005794,GO:0005802,GO:0005829,GO:0005856,GO:0006508,GO:0008233,GO:0042147,GO:0043001,GO:2000300" "serine-type endopeptidase activity|nucleus|Golgi apparatus|trans-Golgi network|cytosol|cytoskeleton|proteolysis|peptidase activity|retrograde transport, endosome to Golgi|Golgi to plasma membrane protein transport|regulation of synaptic vesicle exocytosis" PREX1 2668.885174 2794.551689 2543.21866 0.910063203 -0.135961353 0.565881133 1 22.2166077 19.88018765 57580 "phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1" "GO:0005085,GO:0005096,GO:0005515,GO:0005543,GO:0005829,GO:0005886,GO:0006801,GO:0007186,GO:0019899,GO:0030041,GO:0030217,GO:0030335,GO:0030426,GO:0030593,GO:0030833,GO:0035556,GO:0042119,GO:0043065,GO:0043198,GO:0043547,GO:0048471,GO:0050773,GO:0051056,GO:1900026" guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|phospholipid binding|cytosol|plasma membrane|superoxide metabolic process|G protein-coupled receptor signaling pathway|enzyme binding|actin filament polymerization|T cell differentiation|positive regulation of cell migration|growth cone|neutrophil chemotaxis|regulation of actin filament polymerization|intracellular signal transduction|neutrophil activation|positive regulation of apoptotic process|dendritic shaft|positive regulation of GTPase activity|perinuclear region of cytoplasm|regulation of dendrite development|regulation of small GTPase mediated signal transduction|positive regulation of substrate adhesion-dependent cell spreading "hsa04062,hsa05167" Chemokine signaling pathway|Kaposi sarcoma-associated herpesvirus infection PRH1 8.967435311 8.323311061 9.61155956 1.154775965 0.207612985 0.965671908 1 0.38359224 0.435550711 5554 proline rich protein HaeIII subfamily 1 "GO:0005515,GO:0005615" protein binding|extracellular space hsa04970 Salivary secretion PRH1-TAS2R14 7.966650391 7.282897178 8.650403604 1.187769564 0.248254969 0.952730603 1 0.228901553 0.267332716 106707243 PRH1-TAS2R14 readthrough PRICKLE1 31.30676566 27.05076095 35.56277037 1.314668021 0.394698538 0.605291203 1 0.210413846 0.27199542 144165 prickle planar cell polarity protein 1 "GO:0001843,GO:0005515,GO:0005634,GO:0005829,GO:0006606,GO:0008270,GO:0031398,GO:0031965,GO:0032436,GO:0035904,GO:0045892,GO:0060071,GO:0060976,GO:0090090,GO:2000691" "neural tube closure|protein binding|nucleus|cytosol|protein import into nucleus|zinc ion binding|positive regulation of protein ubiquitination|nuclear membrane|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|aorta development|negative regulation of transcription, DNA-templated|Wnt signaling pathway, planar cell polarity pathway|coronary vasculature development|negative regulation of canonical Wnt signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation" hsa04310 Wnt signaling pathway PRICKLE2 59.08090878 74.90979955 43.25201802 0.577387982 -0.792387015 0.160517819 1 0.176628008 0.100276343 166336 prickle planar cell polarity protein 2 "GO:0005737,GO:0008270,GO:0031965,GO:0060071" "cytoplasm|zinc ion binding|nuclear membrane|Wnt signaling pathway, planar cell polarity pathway" hsa04310 Wnt signaling pathway PRICKLE3 602.1951187 619.0462602 585.3439772 0.945557731 -0.08076255 0.763635195 1 11.53942059 10.72860439 4007 prickle planar cell polarity protein 3 "GO:0005515,GO:0005737,GO:0005886,GO:0007275,GO:0008150,GO:0008270,GO:0030030" protein binding|cytoplasm|plasma membrane|multicellular organism development|biological_process|zinc ion binding|cell projection organization hsa04310 Wnt signaling pathway PRICKLE4 163.0191158 141.496288 184.5419436 1.30421756 0.38318455 0.332563617 1 4.426375635 5.676354217 29964 prickle planar cell polarity protein 4 "GO:0001725,GO:0003674,GO:0003779,GO:0005634,GO:0005912,GO:0007507,GO:0008150,GO:0008270,GO:0030018,GO:0030036,GO:0031941,GO:0051371,GO:0061061" stress fiber|molecular_function|actin binding|nucleus|adherens junction|heart development|biological_process|zinc ion binding|Z disc|actin cytoskeleton organization|filamentous actin|muscle alpha-actinin binding|muscle structure development hsa04310 Wnt signaling pathway PRIM1 1153.072804 1177.748515 1128.397092 0.958096807 -0.06175666 0.802296542 1 44.17025555 41.6112233 5557 DNA primase subunit 1 "GO:0000082,GO:0003896,GO:0005515,GO:0005654,GO:0005658,GO:0006269,GO:0006270,GO:0016020,GO:0032201,GO:0046872" "G1/S transition of mitotic cell cycle|DNA primase activity|protein binding|nucleoplasm|alpha DNA polymerase:primase complex|DNA replication, synthesis of RNA primer|DNA replication initiation|membrane|telomere maintenance via semi-conservative replication|metal ion binding" hsa03030 DNA replication PRIM2 653.3942798 575.3488771 731.4396825 1.271297662 0.346301863 0.181399749 1 4.512169306 5.640320906 5558 DNA primase subunit 2 "GO:0000082,GO:0003677,GO:0005515,GO:0005654,GO:0005658,GO:0006269,GO:0006270,GO:0032201,GO:0046872,GO:0051539" "G1/S transition of mitotic cell cycle|DNA binding|protein binding|nucleoplasm|alpha DNA polymerase:primase complex|DNA replication, synthesis of RNA primer|DNA replication initiation|telomere maintenance via semi-conservative replication|metal ion binding|4 iron, 4 sulfur cluster binding" hsa03030 DNA replication PRIMPOL 407.4433795 414.0847253 400.8020336 0.967922768 -0.047036157 0.878523943 1 8.562162237 8.14883149 201973 primase and DNA directed polymerase "GO:0003682,GO:0003887,GO:0003896,GO:0005515,GO:0005634,GO:0005657,GO:0005759,GO:0006264,GO:0006269,GO:0008270,GO:0009411,GO:0019985,GO:0030145,GO:0031297,GO:0042276,GO:0043504,GO:0062176" "chromatin binding|DNA-directed DNA polymerase activity|DNA primase activity|protein binding|nucleus|replication fork|mitochondrial matrix|mitochondrial DNA replication|DNA replication, synthesis of RNA primer|zinc ion binding|response to UV|translesion synthesis|manganese ion binding|replication fork processing|error-prone translesion synthesis|mitochondrial DNA repair|R-loop disassembly" PRKAA1 2667.885618 2591.670982 2744.100254 1.058815056 0.082450614 0.728383017 1 20.56083202 21.40582505 5562 protein kinase AMP-activated catalytic subunit alpha 1 "GO:0000187,GO:0001666,GO:0003682,GO:0004672,GO:0004674,GO:0004679,GO:0004691,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006006,GO:0006468,GO:0006633,GO:0006695,GO:0007050,GO:0007165,GO:0008022,GO:0008284,GO:0008610,GO:0009411,GO:0009631,GO:0010332,GO:0010508,GO:0010628,GO:0010629,GO:0014823,GO:0015721,GO:0016055,GO:0016236,GO:0016241,GO:0016324,GO:0016607,GO:0019395,GO:0030424,GO:0030425,GO:0031000,GO:0031588,GO:0031669,GO:0032007,GO:0033135,GO:0034599,GO:0035174,GO:0035404,GO:0035556,GO:0035690,GO:0038183,GO:0042149,GO:0042593,GO:0042752,GO:0043025,GO:0043066,GO:0044877,GO:0045542,GO:0045821,GO:0046318,GO:0046627,GO:0046872,GO:0047322,GO:0048156,GO:0048511,GO:0048643,GO:0050321,GO:0050405,GO:0050995,GO:0055089,GO:0060627,GO:0061744,GO:0061762,GO:0062028,GO:0070050,GO:0070301,GO:0070507,GO:0071277,GO:0071333,GO:0071361,GO:0071380,GO:0071417,GO:0071456,GO:0097009,GO:0106310,GO:0106311,GO:0120188,GO:1901563,GO:1901796,GO:1903109,GO:1903829,GO:1903955,GO:1904428,GO:1904486,GO:2000758" activation of MAPK activity|response to hypoxia|chromatin binding|protein kinase activity|protein serine/threonine kinase activity|AMP-activated protein kinase activity|cAMP-dependent protein kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|glucose metabolic process|protein phosphorylation|fatty acid biosynthetic process|cholesterol biosynthetic process|cell cycle arrest|signal transduction|protein C-terminus binding|positive regulation of cell population proliferation|lipid biosynthetic process|response to UV|cold acclimation|response to gamma radiation|positive regulation of autophagy|positive regulation of gene expression|negative regulation of gene expression|response to activity|bile acid and bile salt transport|Wnt signaling pathway|macroautophagy|regulation of macroautophagy|apical plasma membrane|nuclear speck|fatty acid oxidation|axon|dendrite|response to caffeine|nucleotide-activated protein kinase complex|cellular response to nutrient levels|negative regulation of TOR signaling|regulation of peptidyl-serine phosphorylation|cellular response to oxidative stress|histone serine kinase activity|histone-serine phosphorylation|intracellular signal transduction|cellular response to drug|bile acid signaling pathway|cellular response to glucose starvation|glucose homeostasis|regulation of circadian rhythm|neuronal cell body|negative regulation of apoptotic process|protein-containing complex binding|positive regulation of cholesterol biosynthetic process|positive regulation of glycolytic process|negative regulation of glucosylceramide biosynthetic process|negative regulation of insulin receptor signaling pathway|metal ion binding|[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity|tau protein binding|rhythmic process|positive regulation of skeletal muscle tissue development|tau-protein kinase activity|[acetyl-CoA carboxylase] kinase activity|negative regulation of lipid catabolic process|fatty acid homeostasis|regulation of vesicle-mediated transport|motor behavior|CAMKK-AMPK signaling cascade|regulation of stress granule assembly|neuron cellular homeostasis|cellular response to hydrogen peroxide|regulation of microtubule cytoskeleton organization|cellular response to calcium ion|cellular response to glucose stimulus|cellular response to ethanol|cellular response to prostaglandin E stimulus|cellular response to organonitrogen compound|cellular response to hypoxia|energy homeostasis|protein serine kinase activity|protein threonine kinase activity|regulation of bile acid secretion|response to camptothecin|regulation of signal transduction by p53 class mediator|positive regulation of mitochondrial transcription|positive regulation of cellular protein localization|positive regulation of protein targeting to mitochondrion|negative regulation of tubulin deacetylation|response to 17alpha-ethynylestradiol|positive regulation of peptidyl-lysine acetylation "hsa04068,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04371,hsa04530,hsa04710,hsa04714,hsa04910,hsa04920,hsa04921,hsa04922,hsa04931,hsa04932,hsa05410,hsa05418" FoxO signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Hypertrophic cardiomyopathy|Fluid shear stress and atherosclerosis PRKAA2 410.6344326 346.4578229 474.8110423 1.370472857 0.454673755 0.113383419 1 1.632799121 2.200261882 5563 protein kinase AMP-activated catalytic subunit alpha 2 "GO:0003682,GO:0004672,GO:0004674,GO:0004679,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006468,GO:0006633,GO:0006695,GO:0006853,GO:0007050,GO:0007165,GO:0008610,GO:0010494,GO:0010508,GO:0010629,GO:0014850,GO:0016055,GO:0016236,GO:0016239,GO:0016241,GO:0016607,GO:0030424,GO:0030425,GO:0031669,GO:0032007,GO:0034599,GO:0035174,GO:0035404,GO:0035556,GO:0035690,GO:0042149,GO:0042304,GO:0042593,GO:0042752,GO:0043025,GO:0043066,GO:0045821,GO:0046872,GO:0047322,GO:0048511,GO:0050405,GO:0055089,GO:0062028,GO:0070507,GO:0071277,GO:0071333,GO:0071380,GO:0097009,GO:0106310,GO:0106311,GO:1901796,GO:1903829,GO:1904428,GO:2000758" chromatin binding|protein kinase activity|protein serine/threonine kinase activity|AMP-activated protein kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|protein phosphorylation|fatty acid biosynthetic process|cholesterol biosynthetic process|carnitine shuttle|cell cycle arrest|signal transduction|lipid biosynthetic process|cytoplasmic stress granule|positive regulation of autophagy|negative regulation of gene expression|response to muscle activity|Wnt signaling pathway|macroautophagy|positive regulation of macroautophagy|regulation of macroautophagy|nuclear speck|axon|dendrite|cellular response to nutrient levels|negative regulation of TOR signaling|cellular response to oxidative stress|histone serine kinase activity|histone-serine phosphorylation|intracellular signal transduction|cellular response to drug|cellular response to glucose starvation|regulation of fatty acid biosynthetic process|glucose homeostasis|regulation of circadian rhythm|neuronal cell body|negative regulation of apoptotic process|positive regulation of glycolytic process|metal ion binding|[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity|rhythmic process|[acetyl-CoA carboxylase] kinase activity|fatty acid homeostasis|regulation of stress granule assembly|regulation of microtubule cytoskeleton organization|cellular response to calcium ion|cellular response to glucose stimulus|cellular response to prostaglandin E stimulus|energy homeostasis|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator|positive regulation of cellular protein localization|negative regulation of tubulin deacetylation|positive regulation of peptidyl-lysine acetylation "hsa04068,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04371,hsa04530,hsa04710,hsa04714,hsa04910,hsa04920,hsa04921,hsa04922,hsa04931,hsa04932,hsa05410,hsa05418" FoxO signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Hypertrophic cardiomyopathy|Fluid shear stress and atherosclerosis PRKAB1 829.2544085 852.0989699 806.4098471 0.946380498 -0.079507751 0.754731608 1 18.94000664 17.62451146 5564 protein kinase AMP-activated non-catalytic subunit beta 1 "GO:0004672,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006633,GO:0007050,GO:0007165,GO:0010628,GO:0016236,GO:0016241,GO:0019901,GO:0031588,GO:0035878,GO:0050790,GO:0120162,GO:1901796" protein kinase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|fatty acid biosynthetic process|cell cycle arrest|signal transduction|positive regulation of gene expression|macroautophagy|regulation of macroautophagy|protein kinase binding|nucleotide-activated protein kinase complex|nail development|regulation of catalytic activity|positive regulation of cold-induced thermogenesis|regulation of signal transduction by p53 class mediator "hsa04068,hsa04152,hsa04211,hsa04213,hsa04371,hsa04530,hsa04710,hsa04714,hsa04910,hsa04920,hsa04921,hsa04922,hsa04931,hsa04932,hsa05410" FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Hypertrophic cardiomyopathy PRKAB2 902.2670482 939.493736 865.0403604 0.9207516 -0.119116096 0.633926227 1 9.319526761 8.437378276 5565 protein kinase AMP-activated non-catalytic subunit beta 2 "GO:0004679,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006633,GO:0006853,GO:0007050,GO:0007165,GO:0016236,GO:0016241,GO:0019901,GO:0031588,GO:0042304,GO:0042802,GO:0050790,GO:0120162,GO:1901796" AMP-activated protein kinase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|fatty acid biosynthetic process|carnitine shuttle|cell cycle arrest|signal transduction|macroautophagy|regulation of macroautophagy|protein kinase binding|nucleotide-activated protein kinase complex|regulation of fatty acid biosynthetic process|identical protein binding|regulation of catalytic activity|positive regulation of cold-induced thermogenesis|regulation of signal transduction by p53 class mediator "hsa04068,hsa04152,hsa04211,hsa04213,hsa04371,hsa04530,hsa04710,hsa04714,hsa04910,hsa04920,hsa04921,hsa04922,hsa04931,hsa04932,hsa05410" FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Hypertrophic cardiomyopathy PRKACA 1503.899144 1266.183695 1741.614592 1.375483351 0.459938677 0.05404628 1 20.63955304 27.91430407 5566 protein kinase cAMP-activated catalytic subunit alpha "GO:0000086,GO:0000287,GO:0001669,GO:0001707,GO:0001843,GO:0002027,GO:0002223,GO:0003091,GO:0004672,GO:0004674,GO:0004679,GO:0004691,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005813,GO:0005829,GO:0005930,GO:0005952,GO:0006397,GO:0006468,GO:0007596,GO:0010389,GO:0010737,GO:0010881,GO:0016020,GO:0016241,GO:0016607,GO:0018105,GO:0018107,GO:0019221,GO:0019901,GO:0019904,GO:0030145,GO:0031594,GO:0031625,GO:0034199,GO:0034237,GO:0034380,GO:0034605,GO:0034704,GO:0035584,GO:0036126,GO:0043197,GO:0043393,GO:0044853,GO:0045667,GO:0046777,GO:0046827,GO:0048240,GO:0048471,GO:0050804,GO:0051480,GO:0055117,GO:0060314,GO:0061136,GO:0070062,GO:0070613,GO:0071158,GO:0071333,GO:0071374,GO:0071377,GO:0071872,GO:0086064,GO:0097546,GO:0097711,GO:1901621,GO:1903779,GO:2000810" G2/M transition of mitotic cell cycle|magnesium ion binding|acrosomal vesicle|mesoderm formation|neural tube closure|regulation of heart rate|stimulatory C-type lectin receptor signaling pathway|renal water homeostasis|protein kinase activity|protein serine/threonine kinase activity|AMP-activated protein kinase activity|cAMP-dependent protein kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|centrosome|cytosol|axoneme|cAMP-dependent protein kinase complex|mRNA processing|protein phosphorylation|blood coagulation|regulation of G2/M transition of mitotic cell cycle|protein kinase A signaling|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|membrane|regulation of macroautophagy|nuclear speck|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|cytokine-mediated signaling pathway|protein kinase binding|protein domain specific binding|manganese ion binding|neuromuscular junction|ubiquitin protein ligase binding|activation of protein kinase A activity|protein kinase A regulatory subunit binding|high-density lipoprotein particle assembly|cellular response to heat|calcium channel complex|calcium-mediated signaling using intracellular calcium source|sperm flagellum|dendritic spine|regulation of protein binding|plasma membrane raft|regulation of osteoblast differentiation|protein autophosphorylation|positive regulation of protein export from nucleus|sperm capacitation|perinuclear region of cytoplasm|modulation of chemical synaptic transmission|regulation of cytosolic calcium ion concentration|regulation of cardiac muscle contraction|regulation of ryanodine-sensitive calcium-release channel activity|regulation of proteasomal protein catabolic process|extracellular exosome|regulation of protein processing|positive regulation of cell cycle arrest|cellular response to glucose stimulus|cellular response to parathyroid hormone stimulus|cellular response to glucagon stimulus|cellular response to epinephrine stimulus|cell communication by electrical coupling involved in cardiac conduction|ciliary base|ciliary basal body-plasma membrane docking|negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|regulation of cardiac conduction|regulation of bicellular tight junction assembly "hsa01522,hsa04010,hsa04014,hsa04020,hsa04024,hsa04062,hsa04114,hsa04140,hsa04211,hsa04213,hsa04261,hsa04270,hsa04310,hsa04340,hsa04371,hsa04530,hsa04540,hsa04611,hsa04713,hsa04714,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04740,hsa04742,hsa04750,hsa04910,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04919,hsa04921,hsa04922,hsa04923,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa04961,hsa04962,hsa04970,hsa04971,hsa04976,hsa05012,hsa05020,hsa05030,hsa05031,hsa05032,hsa05034,hsa05110,hsa05146,hsa05163,hsa05165,hsa05166,hsa05200,hsa05203,hsa05205,hsa05414" "Endocrine resistance|MAPK signaling pathway|Ras signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Oocyte meiosis|Autophagy - animal|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Hedgehog signaling pathway|Apelin signaling pathway|Tight junction|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Olfactory transduction|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Vasopressin-regulated water reabsorption|Salivary secretion|Gastric acid secretion|Bile secretion|Parkinson disease|Prion disease|Cocaine addiction|Amphetamine addiction|Morphine addiction|Alcoholism|Vibrio cholerae infection|Amoebiasis|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|Dilated cardiomyopathy" PRKACB 1018.060574 1102.838716 933.2824333 0.846254688 -0.240836174 0.326895597 1 8.865262136 7.376729321 5567 protein kinase cAMP-activated catalytic subunit beta "GO:0000287,GO:0001843,GO:0002223,GO:0003091,GO:0004679,GO:0004691,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0005886,GO:0005952,GO:0006468,GO:0007165,GO:0007188,GO:0007596,GO:0010737,GO:0031625,GO:0034199,GO:0034380,GO:0048471,GO:0051447,GO:0070062,GO:0070613,GO:0071377,GO:0097338,GO:0097546,GO:1901621" magnesium ion binding|neural tube closure|stimulatory C-type lectin receptor signaling pathway|renal water homeostasis|AMP-activated protein kinase activity|cAMP-dependent protein kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|centrosome|cytosol|plasma membrane|cAMP-dependent protein kinase complex|protein phosphorylation|signal transduction|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|blood coagulation|protein kinase A signaling|ubiquitin protein ligase binding|activation of protein kinase A activity|high-density lipoprotein particle assembly|perinuclear region of cytoplasm|negative regulation of meiotic cell cycle|extracellular exosome|regulation of protein processing|cellular response to glucagon stimulus|response to clozapine|ciliary base|negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning "hsa01522,hsa04010,hsa04014,hsa04020,hsa04024,hsa04062,hsa04114,hsa04140,hsa04211,hsa04213,hsa04261,hsa04270,hsa04310,hsa04340,hsa04371,hsa04530,hsa04540,hsa04611,hsa04713,hsa04714,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04740,hsa04742,hsa04750,hsa04910,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04919,hsa04921,hsa04922,hsa04923,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04935,hsa04961,hsa04962,hsa04970,hsa04971,hsa04976,hsa05012,hsa05020,hsa05030,hsa05031,hsa05032,hsa05034,hsa05110,hsa05146,hsa05163,hsa05165,hsa05166,hsa05200,hsa05203,hsa05205,hsa05414" "Endocrine resistance|MAPK signaling pathway|Ras signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Oocyte meiosis|Autophagy - animal|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Hedgehog signaling pathway|Apelin signaling pathway|Tight junction|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Olfactory transduction|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Growth hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Vasopressin-regulated water reabsorption|Salivary secretion|Gastric acid secretion|Bile secretion|Parkinson disease|Prion disease|Cocaine addiction|Amphetamine addiction|Morphine addiction|Alcoholism|Vibrio cholerae infection|Amoebiasis|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|Dilated cardiomyopathy" PRKAG1 1638.11192 1635.530624 1640.693217 1.003156525 0.004546731 0.987663931 1 38.46860441 37.9442796 5571 protein kinase AMP-activated non-catalytic subunit gamma 1 "GO:0004672,GO:0004691,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006110,GO:0006468,GO:0006633,GO:0007050,GO:0007165,GO:0007283,GO:0008603,GO:0010628,GO:0016020,GO:0016208,GO:0016236,GO:0016241,GO:0019887,GO:0019901,GO:0031588,GO:0042149,GO:0043531,GO:0045860,GO:0050790,GO:0051170,GO:1901796,GO:2000479" protein kinase activity|cAMP-dependent protein kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of glycolytic process|protein phosphorylation|fatty acid biosynthetic process|cell cycle arrest|signal transduction|spermatogenesis|cAMP-dependent protein kinase regulator activity|positive regulation of gene expression|membrane|AMP binding|macroautophagy|regulation of macroautophagy|protein kinase regulator activity|protein kinase binding|nucleotide-activated protein kinase complex|cellular response to glucose starvation|ADP binding|positive regulation of protein kinase activity|regulation of catalytic activity|import into nucleus|regulation of signal transduction by p53 class mediator|regulation of cAMP-dependent protein kinase activity "hsa04068,hsa04152,hsa04211,hsa04213,hsa04371,hsa04530,hsa04710,hsa04714,hsa04910,hsa04920,hsa04921,hsa04922,hsa04931,hsa04932,hsa05410" FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Hypertrophic cardiomyopathy PRKAG2 1355.306199 1301.557767 1409.054631 1.082590928 0.114488204 0.635058481 1 8.189312176 8.717320005 51422 protein kinase AMP-activated non-catalytic subunit gamma 2 "GO:0004862,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005977,GO:0006110,GO:0006468,GO:0006469,GO:0006633,GO:0006754,GO:0006853,GO:0007050,GO:0008603,GO:0008607,GO:0010800,GO:0016126,GO:0016208,GO:0016236,GO:0016241,GO:0019217,GO:0019887,GO:0019901,GO:0030295,GO:0031588,GO:0032147,GO:0035556,GO:0042149,GO:0042304,GO:0043531,GO:0045860,GO:0046320,GO:0046324,GO:0050790,GO:1901796,GO:2000480" cAMP-dependent protein kinase inhibitor activity|protein binding|ATP binding|extracellular space|nucleus|nucleoplasm|cytoplasm|cytosol|glycogen metabolic process|regulation of glycolytic process|protein phosphorylation|negative regulation of protein kinase activity|fatty acid biosynthetic process|ATP biosynthetic process|carnitine shuttle|cell cycle arrest|cAMP-dependent protein kinase regulator activity|phosphorylase kinase regulator activity|positive regulation of peptidyl-threonine phosphorylation|sterol biosynthetic process|AMP binding|macroautophagy|regulation of macroautophagy|regulation of fatty acid metabolic process|protein kinase regulator activity|protein kinase binding|protein kinase activator activity|nucleotide-activated protein kinase complex|activation of protein kinase activity|intracellular signal transduction|cellular response to glucose starvation|regulation of fatty acid biosynthetic process|ADP binding|positive regulation of protein kinase activity|regulation of fatty acid oxidation|regulation of glucose import|regulation of catalytic activity|regulation of signal transduction by p53 class mediator|negative regulation of cAMP-dependent protein kinase activity "hsa04068,hsa04152,hsa04211,hsa04213,hsa04371,hsa04530,hsa04710,hsa04714,hsa04910,hsa04920,hsa04921,hsa04922,hsa04931,hsa04932,hsa05410" FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Hypertrophic cardiomyopathy PRKAR1A 7371.403589 7111.228888 7631.578291 1.073172923 0.10188256 0.678078638 1 85.51446955 90.23613622 5573 protein kinase cAMP-dependent type I regulatory subunit alpha "GO:0001707,GO:0001772,GO:0003091,GO:0004862,GO:0005515,GO:0005737,GO:0005771,GO:0005813,GO:0005829,GO:0005930,GO:0005952,GO:0006357,GO:0007143,GO:0007596,GO:0008603,GO:0010738,GO:0016020,GO:0019904,GO:0030552,GO:0031588,GO:0031594,GO:0031625,GO:0032991,GO:0034199,GO:0034236,GO:0035556,GO:0043949,GO:0044853,GO:0045214,GO:0045835,GO:0046007,GO:0060038,GO:0071377,GO:0097224,GO:0097546,GO:0098978,GO:2000480" mesoderm formation|immunological synapse|renal water homeostasis|cAMP-dependent protein kinase inhibitor activity|protein binding|cytoplasm|multivesicular body|centrosome|cytosol|axoneme|cAMP-dependent protein kinase complex|regulation of transcription by RNA polymerase II|female meiotic nuclear division|blood coagulation|cAMP-dependent protein kinase regulator activity|regulation of protein kinase A signaling|membrane|protein domain specific binding|cAMP binding|nucleotide-activated protein kinase complex|neuromuscular junction|ubiquitin protein ligase binding|protein-containing complex|activation of protein kinase A activity|protein kinase A catalytic subunit binding|intracellular signal transduction|regulation of cAMP-mediated signaling|plasma membrane raft|sarcomere organization|negative regulation of meiotic nuclear division|negative regulation of activated T cell proliferation|cardiac muscle cell proliferation|cellular response to glucagon stimulus|sperm connecting piece|ciliary base|glutamatergic synapse|negative regulation of cAMP-dependent protein kinase activity hsa04910 Insulin signaling pathway PRKAR1B 353.4406228 358.9427895 347.9384561 0.969342375 -0.044921774 0.89019817 1 5.847410552 5.573294138 5575 protein kinase cAMP-dependent type I regulatory subunit beta "GO:0003091,GO:0004862,GO:0005515,GO:0005771,GO:0005829,GO:0005886,GO:0005952,GO:0006468,GO:0007596,GO:0007611,GO:0008603,GO:0010738,GO:0030552,GO:0034199,GO:0034236,GO:0043949,GO:0050804,GO:0071377,GO:0097546,GO:0098685,GO:0098686,GO:0098693,GO:0098978,GO:2000480" renal water homeostasis|cAMP-dependent protein kinase inhibitor activity|protein binding|multivesicular body|cytosol|plasma membrane|cAMP-dependent protein kinase complex|protein phosphorylation|blood coagulation|learning or memory|cAMP-dependent protein kinase regulator activity|regulation of protein kinase A signaling|cAMP binding|activation of protein kinase A activity|protein kinase A catalytic subunit binding|regulation of cAMP-mediated signaling|modulation of chemical synaptic transmission|cellular response to glucagon stimulus|ciliary base|Schaffer collateral - CA1 synapse|hippocampal mossy fiber to CA3 synapse|regulation of synaptic vesicle cycle|glutamatergic synapse|negative regulation of cAMP-dependent protein kinase activity hsa04910 Insulin signaling pathway PRKAR2A 1207.184386 1260.981626 1153.387147 0.914674031 -0.128670403 0.596632186 1 9.669004566 8.695995235 5576 protein kinase cAMP-dependent type II regulatory subunit alpha "GO:0003091,GO:0004862,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0005925,GO:0005930,GO:0005952,GO:0007596,GO:0008603,GO:0010738,GO:0016020,GO:0019904,GO:0030552,GO:0031588,GO:0031625,GO:0032991,GO:0034199,GO:0034236,GO:0035556,GO:0043949,GO:0044853,GO:0070062,GO:0071377,GO:0097546,GO:2000480" renal water homeostasis|cAMP-dependent protein kinase inhibitor activity|protein binding|cytoplasm|centrosome|cytosol|plasma membrane|focal adhesion|axoneme|cAMP-dependent protein kinase complex|blood coagulation|cAMP-dependent protein kinase regulator activity|regulation of protein kinase A signaling|membrane|protein domain specific binding|cAMP binding|nucleotide-activated protein kinase complex|ubiquitin protein ligase binding|protein-containing complex|activation of protein kinase A activity|protein kinase A catalytic subunit binding|intracellular signal transduction|regulation of cAMP-mediated signaling|plasma membrane raft|extracellular exosome|cellular response to glucagon stimulus|ciliary base|negative regulation of cAMP-dependent protein kinase activity hsa04910 Insulin signaling pathway PRKAR2B 644.3626778 527.4898385 761.2355171 1.443128306 0.529199573 0.041586786 1 6.950904493 9.86319104 5577 protein kinase cAMP-dependent type II regulatory subunit beta "GO:0000086,GO:0003091,GO:0004862,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0005952,GO:0006631,GO:0007596,GO:0007612,GO:0008603,GO:0010389,GO:0010738,GO:0019904,GO:0030552,GO:0031625,GO:0034199,GO:0034236,GO:0035556,GO:0043025,GO:0043197,GO:0043198,GO:0043949,GO:0045121,GO:0048471,GO:0050804,GO:0070062,GO:0071377,GO:0097332,GO:0097338,GO:0097546,GO:0097711,GO:0098978,GO:2000480" G2/M transition of mitotic cell cycle|renal water homeostasis|cAMP-dependent protein kinase inhibitor activity|protein binding|cytoplasm|centrosome|cytosol|plasma membrane|cAMP-dependent protein kinase complex|fatty acid metabolic process|blood coagulation|learning|cAMP-dependent protein kinase regulator activity|regulation of G2/M transition of mitotic cell cycle|regulation of protein kinase A signaling|protein domain specific binding|cAMP binding|ubiquitin protein ligase binding|activation of protein kinase A activity|protein kinase A catalytic subunit binding|intracellular signal transduction|neuronal cell body|dendritic spine|dendritic shaft|regulation of cAMP-mediated signaling|membrane raft|perinuclear region of cytoplasm|modulation of chemical synaptic transmission|extracellular exosome|cellular response to glucagon stimulus|response to antipsychotic drug|response to clozapine|ciliary base|ciliary basal body-plasma membrane docking|glutamatergic synapse|negative regulation of cAMP-dependent protein kinase activity hsa04910 Insulin signaling pathway PRKCA 1840.230845 1844.653814 1835.807876 0.995204554 -0.006935008 0.979217489 1 7.930222629 7.760128501 5578 protein kinase C alpha "GO:0001525,GO:0001938,GO:0002159,GO:0004672,GO:0004674,GO:0004697,GO:0004698,GO:0005178,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0005886,GO:0006468,GO:0007077,GO:0007155,GO:0007411,GO:0008270,GO:0010595,GO:0010613,GO:0018105,GO:0018107,GO:0019899,GO:0030168,GO:0030335,GO:0031666,GO:0031966,GO:0034351,GO:0035403,GO:0035408,GO:0035556,GO:0035866,GO:0038128,GO:0043488,GO:0043536,GO:0045651,GO:0045766,GO:0045780,GO:0045785,GO:0045931,GO:0048471,GO:0050796,GO:0070062,GO:0070374,GO:0070555,GO:0090330,GO:0097190,GO:0106071,GO:2000707" angiogenesis|positive regulation of endothelial cell proliferation|desmosome assembly|protein kinase activity|protein serine/threonine kinase activity|protein kinase C activity|calcium-dependent protein kinase C activity|integrin binding|protein binding|ATP binding|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|plasma membrane|protein phosphorylation|mitotic nuclear envelope disassembly|cell adhesion|axon guidance|zinc ion binding|positive regulation of endothelial cell migration|positive regulation of cardiac muscle hypertrophy|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|enzyme binding|platelet activation|positive regulation of cell migration|positive regulation of lipopolysaccharide-mediated signaling pathway|mitochondrial membrane|negative regulation of glial cell apoptotic process|histone kinase activity (H3-T6 specific)|histone H3-T6 phosphorylation|intracellular signal transduction|alphav-beta3 integrin-PKCalpha complex|ERBB2 signaling pathway|regulation of mRNA stability|positive regulation of blood vessel endothelial cell migration|positive regulation of macrophage differentiation|positive regulation of angiogenesis|positive regulation of bone resorption|positive regulation of cell adhesion|positive regulation of mitotic cell cycle|perinuclear region of cytoplasm|regulation of insulin secretion|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|response to interleukin-1|regulation of platelet aggregation|apoptotic signaling pathway|positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of dense core granule biogenesis "hsa01521,hsa04010,hsa04012,hsa04014,hsa04015,hsa04020,hsa04066,hsa04070,hsa04071,hsa04072,hsa04150,hsa04151,hsa04261,hsa04270,hsa04310,hsa04360,hsa04370,hsa04510,hsa04540,hsa04650,hsa04664,hsa04666,hsa04670,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04750,hsa04911,hsa04912,hsa04916,hsa04918,hsa04919,hsa04921,hsa04925,hsa04926,hsa04928,hsa04929,hsa04933,hsa04935,hsa04960,hsa04961,hsa04970,hsa04971,hsa04972,hsa05017,hsa05022,hsa05031,hsa05032,hsa05110,hsa05143,hsa05146,hsa05161,hsa05163,hsa05164,hsa05170,hsa05171,hsa05200,hsa05205,hsa05206,hsa05214,hsa05223,hsa05225,hsa05231" "EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|HIF-1 signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Focal adhesion|Gap junction|Natural killer cell mediated cytotoxicity|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|GnRH secretion|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Morphine addiction|Vibrio cholerae infection|African trypanosomiasis|Amoebiasis|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Glioma|Non-small cell lung cancer|Hepatocellular carcinoma|Choline metabolism in cancer" PRKCD 1392.176725 1335.891425 1448.462026 1.08426628 0.116719105 0.62780165 1 22.79951075 24.30707258 5580 protein kinase C delta "GO:0002223,GO:0004672,GO:0004674,GO:0004697,GO:0004698,GO:0004699,GO:0004715,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0005886,GO:0005911,GO:0006468,GO:0006915,GO:0007049,GO:0007165,GO:0008047,GO:0008631,GO:0010469,GO:0016064,GO:0016363,GO:0016572,GO:0018105,GO:0018107,GO:0018108,GO:0019899,GO:0019900,GO:0019901,GO:0023021,GO:0030168,GO:0030837,GO:0032079,GO:0032091,GO:0032147,GO:0032930,GO:0032956,GO:0034351,GO:0034644,GO:0035307,GO:0035556,GO:0035578,GO:0036019,GO:0038096,GO:0042100,GO:0042119,GO:0042307,GO:0042742,GO:0043312,GO:0043407,GO:0043488,GO:0043560,GO:0046627,GO:0046872,GO:0048471,GO:0050728,GO:0050732,GO:0050821,GO:0051490,GO:0060326,GO:0060333,GO:0070062,GO:0070301,GO:0071447,GO:0090331,GO:0090398,GO:0106310,GO:1900163,GO:1904385,GO:2000303,GO:2000304,GO:2000753,GO:2000755,GO:2001022,GO:2001235" stimulatory C-type lectin receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|protein kinase C activity|calcium-dependent protein kinase C activity|calcium-independent protein kinase C activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|plasma membrane|cell-cell junction|protein phosphorylation|apoptotic process|cell cycle|signal transduction|enzyme activator activity|intrinsic apoptotic signaling pathway in response to oxidative stress|regulation of signaling receptor activity|immunoglobulin mediated immune response|nuclear matrix|histone phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|enzyme binding|kinase binding|protein kinase binding|termination of signal transduction|platelet activation|negative regulation of actin filament polymerization|positive regulation of endodeoxyribonuclease activity|negative regulation of protein binding|activation of protein kinase activity|positive regulation of superoxide anion generation|regulation of actin cytoskeleton organization|negative regulation of glial cell apoptotic process|cellular response to UV|positive regulation of protein dephosphorylation|intracellular signal transduction|azurophil granule lumen|endolysosome|Fc-gamma receptor signaling pathway involved in phagocytosis|B cell proliferation|neutrophil activation|positive regulation of protein import into nucleus|defense response to bacterium|neutrophil degranulation|negative regulation of MAP kinase activity|regulation of mRNA stability|insulin receptor substrate binding|negative regulation of insulin receptor signaling pathway|metal ion binding|perinuclear region of cytoplasm|negative regulation of inflammatory response|negative regulation of peptidyl-tyrosine phosphorylation|protein stabilization|negative regulation of filopodium assembly|cell chemotaxis|interferon-gamma-mediated signaling pathway|extracellular exosome|cellular response to hydrogen peroxide|cellular response to hydroperoxide|negative regulation of platelet aggregation|cellular senescence|protein serine kinase activity|positive regulation of phospholipid scramblase activity|cellular response to angiotensin|regulation of ceramide biosynthetic process|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of sphingomyelin catabolic process|positive regulation of response to DNA damage stimulus|positive regulation of apoptotic signaling pathway "hsa04062,hsa04140,hsa04270,hsa04621,hsa04625,hsa04666,hsa04722,hsa04750,hsa04912,hsa04915,hsa04930,hsa04931,hsa04933,hsa05020,hsa05131" Chemokine signaling pathway|Autophagy - animal|Vascular smooth muscle contraction|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Fc gamma R-mediated phagocytosis|Neurotrophin signaling pathway|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Estrogen signaling pathway|Type II diabetes mellitus|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|Prion disease|Shigellosis PRKCE 369.2147933 470.267075 268.1625117 0.570234503 -0.81037276 0.006218619 0.469832129 0.974084591 0.546161828 5581 protein kinase C epsilon "GO:0002281,GO:0003785,GO:0004674,GO:0004697,GO:0004698,GO:0004699,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0006468,GO:0006915,GO:0007049,GO:0007155,GO:0007165,GO:0008047,GO:0010634,GO:0010763,GO:0010811,GO:0018105,GO:0019899,GO:0030168,GO:0030546,GO:0030838,GO:0031397,GO:0031663,GO:0032024,GO:0032230,GO:0032467,GO:0035276,GO:0035556,GO:0035641,GO:0035669,GO:0038096,GO:0043123,GO:0043231,GO:0043278,GO:0043410,GO:0045111,GO:0046872,GO:0048471,GO:0050730,GO:0050790,GO:0050996,GO:0051279,GO:0051301,GO:0061178,GO:0070257,GO:0071361,GO:0071380,GO:0071456,GO:0071889,GO:0071944,GO:0090303,GO:1903078,GO:2000650,GO:2001031" "macrophage activation involved in immune response|actin monomer binding|protein serine/threonine kinase activity|protein kinase C activity|calcium-dependent protein kinase C activity|calcium-independent protein kinase C activity|protein binding|ATP binding|nucleus|cytoplasm|mitochondrion|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|protein phosphorylation|apoptotic process|cell cycle|cell adhesion|signal transduction|enzyme activator activity|positive regulation of epithelial cell migration|positive regulation of fibroblast migration|positive regulation of cell-substrate adhesion|peptidyl-serine phosphorylation|enzyme binding|platelet activation|signaling receptor activator activity|positive regulation of actin filament polymerization|negative regulation of protein ubiquitination|lipopolysaccharide-mediated signaling pathway|positive regulation of insulin secretion|positive regulation of synaptic transmission, GABAergic|positive regulation of cytokinesis|ethanol binding|intracellular signal transduction|locomotory exploration behavior|TRAM-dependent toll-like receptor 4 signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|response to morphine|positive regulation of MAPK cascade|intermediate filament cytoskeleton|metal ion binding|perinuclear region of cytoplasm|regulation of peptidyl-tyrosine phosphorylation|regulation of catalytic activity|positive regulation of lipid catabolic process|regulation of release of sequestered calcium ion into cytosol|cell division|regulation of insulin secretion involved in cellular response to glucose stimulus|positive regulation of mucus secretion|cellular response to ethanol|cellular response to prostaglandin E stimulus|cellular response to hypoxia|14-3-3 protein binding|cell periphery|positive regulation of wound healing|positive regulation of protein localization to plasma membrane|negative regulation of sodium ion transmembrane transporter activity|positive regulation of cellular glucuronidation" "hsa04022,hsa04071,hsa04270,hsa04371,hsa04530,hsa04666,hsa04750,hsa04925,hsa04930,hsa04931,hsa04933,hsa05131,hsa05206" cGMP-PKG signaling pathway|Sphingolipid signaling pathway|Vascular smooth muscle contraction|Apelin signaling pathway|Tight junction|Fc gamma R-mediated phagocytosis|Inflammatory mediator regulation of TRP channels|Aldosterone synthesis and secretion|Type II diabetes mellitus|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|Shigellosis|MicroRNAs in cancer PRKCG 21.70023652 14.56579436 28.83467868 1.979615939 0.985220564 0.238975142 1 0.255119683 0.496587847 5582 protein kinase C gamma "GO:0004672,GO:0004674,GO:0004697,GO:0004698,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0005886,GO:0005911,GO:0006468,GO:0007268,GO:0007611,GO:0007635,GO:0008270,GO:0014069,GO:0016310,GO:0018105,GO:0030168,GO:0030425,GO:0031397,GO:0032095,GO:0032425,GO:0035556,GO:0042177,GO:0042752,GO:0043278,GO:0043524,GO:0044305,GO:0046777,GO:0048265,GO:0048471,GO:0048511,GO:0050764,GO:0060384,GO:0097060,GO:0099171,GO:0099523,GO:0099524,GO:1901799,GO:1990911,GO:2000300" protein kinase activity|protein serine/threonine kinase activity|protein kinase C activity|calcium-dependent protein kinase C activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleus|cytosol|plasma membrane|cell-cell junction|protein phosphorylation|chemical synaptic transmission|learning or memory|chemosensory behavior|zinc ion binding|postsynaptic density|phosphorylation|peptidyl-serine phosphorylation|platelet activation|dendrite|negative regulation of protein ubiquitination|regulation of response to food|positive regulation of mismatch repair|intracellular signal transduction|negative regulation of protein catabolic process|regulation of circadian rhythm|response to morphine|negative regulation of neuron apoptotic process|calyx of Held|protein autophosphorylation|response to pain|perinuclear region of cytoplasm|rhythmic process|regulation of phagocytosis|innervation|synaptic membrane|presynaptic modulation of chemical synaptic transmission|presynaptic cytosol|postsynaptic cytosol|negative regulation of proteasomal protein catabolic process|response to psychosocial stress|regulation of synaptic vesicle exocytosis "hsa01521,hsa04010,hsa04012,hsa04014,hsa04015,hsa04020,hsa04066,hsa04070,hsa04071,hsa04150,hsa04270,hsa04310,hsa04370,hsa04510,hsa04540,hsa04650,hsa04666,hsa04670,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04750,hsa04911,hsa04916,hsa04918,hsa04919,hsa04921,hsa04925,hsa04928,hsa04929,hsa04935,hsa04960,hsa04961,hsa04970,hsa04971,hsa04972,hsa05017,hsa05022,hsa05031,hsa05032,hsa05143,hsa05146,hsa05161,hsa05163,hsa05170,hsa05171,hsa05200,hsa05205,hsa05206,hsa05214,hsa05223,hsa05225,hsa05231" "EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|HIF-1 signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|mTOR signaling pathway|Vascular smooth muscle contraction|Wnt signaling pathway|VEGF signaling pathway|Focal adhesion|Gap junction|Natural killer cell mediated cytotoxicity|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|Insulin secretion|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Aldosterone synthesis and secretion|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Growth hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Morphine addiction|African trypanosomiasis|Amoebiasis|Hepatitis B|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Glioma|Non-small cell lung cancer|Hepatocellular carcinoma|Choline metabolism in cancer" PRKCH 488.7893911 493.1561804 484.4226018 0.982290441 -0.025778435 0.93314194 1 3.037723795 2.933995068 5583 protein kinase C eta "GO:0004674,GO:0004697,GO:0004698,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0007165,GO:0010744,GO:0018105,GO:0019899,GO:0030168,GO:0034351,GO:0035556,GO:0045618,GO:0046872,GO:0050861,GO:0051092,GO:0060252,GO:0070062,GO:1903078,GO:2000810" protein serine/threonine kinase activity|protein kinase C activity|calcium-dependent protein kinase C activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|protein phosphorylation|signal transduction|positive regulation of macrophage derived foam cell differentiation|peptidyl-serine phosphorylation|enzyme binding|platelet activation|negative regulation of glial cell apoptotic process|intracellular signal transduction|positive regulation of keratinocyte differentiation|metal ion binding|positive regulation of B cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of glial cell proliferation|extracellular exosome|positive regulation of protein localization to plasma membrane|regulation of bicellular tight junction assembly "hsa04270,hsa04750" Vascular smooth muscle contraction|Inflammatory mediator regulation of TRP channels PRKCI 2466.449832 2476.185041 2456.714624 0.99213693 -0.011388847 0.963439122 1 27.04101588 26.37945368 5584 protein kinase C iota "GO:0000139,GO:0004672,GO:0004674,GO:0004697,GO:0004698,GO:0005515,GO:0005524,GO:0005543,GO:0005634,GO:0005654,GO:0005768,GO:0005829,GO:0005886,GO:0005923,GO:0006468,GO:0006612,GO:0007010,GO:0007015,GO:0010976,GO:0015630,GO:0016192,GO:0016324,GO:0016477,GO:0018105,GO:0031252,GO:0032869,GO:0034351,GO:0035089,GO:0035556,GO:0042462,GO:0043066,GO:0043220,GO:0043524,GO:0045171,GO:0045197,GO:0045216,GO:0045747,GO:0046326,GO:0046872,GO:0046903,GO:0048194,GO:0051092,GO:0060252,GO:0061024,GO:0070062,GO:0070555,GO:0070830,GO:0098685,GO:0098978,GO:0099072,GO:1903078,GO:2000353" Golgi membrane|protein kinase activity|protein serine/threonine kinase activity|protein kinase C activity|calcium-dependent protein kinase C activity|protein binding|ATP binding|phospholipid binding|nucleus|nucleoplasm|endosome|cytosol|plasma membrane|bicellular tight junction|protein phosphorylation|protein targeting to membrane|cytoskeleton organization|actin filament organization|positive regulation of neuron projection development|microtubule cytoskeleton|vesicle-mediated transport|apical plasma membrane|cell migration|peptidyl-serine phosphorylation|cell leading edge|cellular response to insulin stimulus|negative regulation of glial cell apoptotic process|establishment of apical/basal cell polarity|intracellular signal transduction|eye photoreceptor cell development|negative regulation of apoptotic process|Schmidt-Lanterman incisure|negative regulation of neuron apoptotic process|intercellular bridge|establishment or maintenance of epithelial cell apical/basal polarity|cell-cell junction organization|positive regulation of Notch signaling pathway|positive regulation of glucose import|metal ion binding|secretion|Golgi vesicle budding|positive regulation of NF-kappaB transcription factor activity|positive regulation of glial cell proliferation|membrane organization|extracellular exosome|response to interleukin-1|bicellular tight junction assembly|Schaffer collateral - CA1 synapse|glutamatergic synapse|regulation of postsynaptic membrane neurotransmitter receptor levels|positive regulation of protein localization to plasma membrane|positive regulation of endothelial cell apoptotic process "hsa04015,hsa04144,hsa04390,hsa04530,hsa04611,hsa04910,hsa05165" Rap1 signaling pathway|Endocytosis|Hippo signaling pathway|Tight junction|Platelet activation|Insulin signaling pathway|Human papillomavirus infection PRKCSH 5104.26467 4656.892539 5551.636802 1.192133328 0.253545596 0.291366287 1 110.457687 129.4767987 5589 protein kinase C substrate 80K-H "GO:0001889,GO:0005080,GO:0005509,GO:0005515,GO:0005783,GO:0005788,GO:0006457,GO:0006491,GO:0017177,GO:0035556,GO:0043231,GO:0043687,GO:0044267,GO:0044325,GO:0051219" liver development|protein kinase C binding|calcium ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|protein folding|N-glycan processing|glucosidase II complex|intracellular signal transduction|intracellular membrane-bounded organelle|post-translational protein modification|cellular protein metabolic process|ion channel binding|phosphoprotein binding hsa04141 Protein processing in endoplasmic reticulum PRKCZ 952.4257954 893.7155252 1011.136066 1.131384694 0.178089558 0.472215496 1 6.817603631 7.584260224 5590 protein kinase C zeta "GO:0000226,GO:0001725,GO:0001954,GO:0004672,GO:0004674,GO:0004698,GO:0005515,GO:0005524,GO:0005635,GO:0005737,GO:0005768,GO:0005815,GO:0005829,GO:0005886,GO:0005911,GO:0005923,GO:0006468,GO:0006954,GO:0007165,GO:0007179,GO:0007616,GO:0008284,GO:0014069,GO:0015459,GO:0016020,GO:0016324,GO:0016363,GO:0016477,GO:0018105,GO:0019901,GO:0030010,GO:0030054,GO:0031252,GO:0031333,GO:0031584,GO:0031982,GO:0032148,GO:0032733,GO:0032736,GO:0032753,GO:0032754,GO:0032869,GO:0035556,GO:0035748,GO:0043066,GO:0043203,GO:0043274,GO:0043560,GO:0044877,GO:0045121,GO:0045179,GO:0045630,GO:0046627,GO:0046628,GO:0046872,GO:0047496,GO:0048471,GO:0050732,GO:0051092,GO:0051222,GO:0051346,GO:0051899,GO:0060081,GO:0060291,GO:0070062,GO:0070374,GO:0070528,GO:0071889,GO:0072659,GO:0098685,GO:0098696,GO:0098978,GO:1990138,GO:2000463,GO:2000553" microtubule cytoskeleton organization|stress fiber|positive regulation of cell-matrix adhesion|protein kinase activity|protein serine/threonine kinase activity|calcium-dependent protein kinase C activity|protein binding|ATP binding|nuclear envelope|cytoplasm|endosome|microtubule organizing center|cytosol|plasma membrane|cell-cell junction|bicellular tight junction|protein phosphorylation|inflammatory response|signal transduction|transforming growth factor beta receptor signaling pathway|long-term memory|positive regulation of cell population proliferation|postsynaptic density|potassium channel regulator activity|membrane|apical plasma membrane|nuclear matrix|cell migration|peptidyl-serine phosphorylation|protein kinase binding|establishment of cell polarity|cell junction|cell leading edge|negative regulation of protein-containing complex assembly|activation of phospholipase D activity|vesicle|activation of protein kinase B activity|positive regulation of interleukin-10 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|cellular response to insulin stimulus|intracellular signal transduction|myelin sheath abaxonal region|negative regulation of apoptotic process|axon hillock|phospholipase binding|insulin receptor substrate binding|protein-containing complex binding|membrane raft|apical cortex|positive regulation of T-helper 2 cell differentiation|negative regulation of insulin receptor signaling pathway|positive regulation of insulin receptor signaling pathway|metal ion binding|vesicle transport along microtubule|perinuclear region of cytoplasm|negative regulation of peptidyl-tyrosine phosphorylation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein transport|negative regulation of hydrolase activity|membrane depolarization|membrane hyperpolarization|long-term synaptic potentiation|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|protein kinase C signaling|14-3-3 protein binding|protein localization to plasma membrane|Schaffer collateral - CA1 synapse|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane|glutamatergic synapse|neuron projection extension|positive regulation of excitatory postsynaptic potential|positive regulation of T-helper 2 cell cytokine production "hsa04015,hsa04062,hsa04071,hsa04144,hsa04360,hsa04390,hsa04530,hsa04611,hsa04910,hsa04926,hsa04930,hsa04931,hsa04933,hsa05165,hsa05418" Rap1 signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Endocytosis|Axon guidance|Hippo signaling pathway|Tight junction|Platelet activation|Insulin signaling pathway|Relaxin signaling pathway|Type II diabetes mellitus|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|Human papillomavirus infection|Fluid shear stress and atherosclerosis PRKD1 496.4685779 518.1261136 474.8110423 0.916400525 -0.12594981 0.650009749 1 3.298906992 2.972532277 5587 protein kinase D1 "GO:0000421,GO:0001525,GO:0001938,GO:0004674,GO:0004697,GO:0004698,GO:0005515,GO:0005524,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0006468,GO:0006915,GO:0006954,GO:0007030,GO:0007165,GO:0007229,GO:0007265,GO:0007399,GO:0010508,GO:0010595,GO:0010837,GO:0010976,GO:0016301,GO:0018105,GO:0018107,GO:0030148,GO:0030154,GO:0031647,GO:0032793,GO:0033138,GO:0034198,GO:0034599,GO:0035556,GO:0035924,GO:0038033,GO:0042802,GO:0043123,GO:0043536,GO:0043552,GO:0045087,GO:0045669,GO:0045766,GO:0045806,GO:0045944,GO:0046777,GO:0046872,GO:0048010,GO:0048193,GO:0051092,GO:0060548,GO:0071447,GO:0089700,GO:1901727,GO:2001028,GO:2001044" autophagosome membrane|angiogenesis|positive regulation of endothelial cell proliferation|protein serine/threonine kinase activity|protein kinase C activity|calcium-dependent protein kinase C activity|protein binding|ATP binding|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|protein phosphorylation|apoptotic process|inflammatory response|Golgi organization|signal transduction|integrin-mediated signaling pathway|Ras protein signal transduction|nervous system development|positive regulation of autophagy|positive regulation of endothelial cell migration|regulation of keratinocyte proliferation|positive regulation of neuron projection development|kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|sphingolipid biosynthetic process|cell differentiation|regulation of protein stability|positive regulation of CREB transcription factor activity|positive regulation of peptidyl-serine phosphorylation|cellular response to amino acid starvation|cellular response to oxidative stress|intracellular signal transduction|cellular response to vascular endothelial growth factor stimulus|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of blood vessel endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase activity|innate immune response|positive regulation of osteoblast differentiation|positive regulation of angiogenesis|negative regulation of endocytosis|positive regulation of transcription by RNA polymerase II|protein autophosphorylation|metal ion binding|vascular endothelial growth factor receptor signaling pathway|Golgi vesicle transport|positive regulation of NF-kappaB transcription factor activity|negative regulation of cell death|cellular response to hydroperoxide|protein kinase D signaling|positive regulation of histone deacetylase activity|positive regulation of endothelial cell chemotaxis|regulation of integrin-mediated signaling pathway "hsa04015,hsa04925" Rap1 signaling pathway|Aldosterone synthesis and secretion PRKD2 697.7703857 667.9457127 727.5950587 1.089302686 0.123404893 0.633561007 1 10.68235992 11.44160524 25865 protein kinase D2 "GO:0001525,GO:0001938,GO:0002250,GO:0004672,GO:0004674,GO:0004698,GO:0005080,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0006468,GO:0007155,GO:0008219,GO:0010595,GO:0018105,GO:0018107,GO:0030148,GO:0030949,GO:0032743,GO:0032757,GO:0032793,GO:0033138,GO:0035556,GO:0035924,GO:0038033,GO:0043536,GO:0045743,GO:0045766,GO:0045785,GO:0045944,GO:0046777,GO:0046872,GO:0048010,GO:0050852,GO:0050862,GO:0051091,GO:0051092,GO:0061154,GO:0070374,GO:0089700,GO:1901727,GO:1902533,GO:2000573,GO:2001028" angiogenesis|positive regulation of endothelial cell proliferation|adaptive immune response|protein kinase activity|protein serine/threonine kinase activity|calcium-dependent protein kinase C activity|protein kinase C binding|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|plasma membrane|protein phosphorylation|cell adhesion|cell death|positive regulation of endothelial cell migration|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|sphingolipid biosynthetic process|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of interleukin-2 production|positive regulation of interleukin-8 production|positive regulation of CREB transcription factor activity|positive regulation of peptidyl-serine phosphorylation|intracellular signal transduction|cellular response to vascular endothelial growth factor stimulus|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of angiogenesis|positive regulation of cell adhesion|positive regulation of transcription by RNA polymerase II|protein autophosphorylation|metal ion binding|vascular endothelial growth factor receptor signaling pathway|T cell receptor signaling pathway|positive regulation of T cell receptor signaling pathway|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|endothelial tube morphogenesis|positive regulation of ERK1 and ERK2 cascade|protein kinase D signaling|positive regulation of histone deacetylase activity|positive regulation of intracellular signal transduction|positive regulation of DNA biosynthetic process|positive regulation of endothelial cell chemotaxis "hsa04015,hsa04925" Rap1 signaling pathway|Aldosterone synthesis and secretion PRKD3 2322.266992 2400.234827 2244.299157 0.935033161 -0.096910564 0.68286749 1 20.65400214 18.98901378 23683 protein kinase D3 "GO:0004697,GO:0004698,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006468,GO:0007205,GO:0016020,GO:0016301,GO:0030148,GO:0046872,GO:0089700" protein kinase C activity|calcium-dependent protein kinase C activity|protein binding|ATP binding|nucleoplasm|cytosol|protein phosphorylation|protein kinase C-activating G protein-coupled receptor signaling pathway|membrane|kinase activity|sphingolipid biosynthetic process|metal ion binding|protein kinase D signaling "hsa04015,hsa04925" Rap1 signaling pathway|Aldosterone synthesis and secretion PRKDC 17302.04278 18402.84076 16201.24479 0.880366516 -0.183823821 0.492060492 1 72.97167607 63.16682034 5591 "protein kinase, DNA-activated, catalytic subunit" "GO:0000460,GO:0000723,GO:0000781,GO:0001756,GO:0001933,GO:0002218,GO:0002326,GO:0002328,GO:0002360,GO:0002638,GO:0003690,GO:0003723,GO:0004672,GO:0004674,GO:0004677,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005829,GO:0005958,GO:0006302,GO:0006303,GO:0006464,GO:0006468,GO:0006974,GO:0007420,GO:0007507,GO:0008134,GO:0008630,GO:0010332,GO:0014823,GO:0016020,GO:0016233,GO:0016567,GO:0018105,GO:0018107,GO:0019899,GO:0019904,GO:0031648,GO:0032040,GO:0032481,GO:0032869,GO:0032991,GO:0032993,GO:0033077,GO:0033152,GO:0033153,GO:0034462,GO:0034511,GO:0035234,GO:0042752,GO:0043065,GO:0043066,GO:0045087,GO:0045621,GO:0045648,GO:0045727,GO:0045944,GO:0048146,GO:0048511,GO:0048536,GO:0048538,GO:0048639,GO:0048660,GO:0050678,GO:0070419,GO:0072431,GO:0097681,GO:0106310,GO:0106311,GO:1902036,GO:1905221,GO:2000773,GO:2001034,GO:2001229" "maturation of 5.8S rRNA|telomere maintenance|chromosome, telomeric region|somitogenesis|negative regulation of protein phosphorylation|activation of innate immune response|B cell lineage commitment|pro-B cell differentiation|T cell lineage commitment|negative regulation of immunoglobulin production|double-stranded DNA binding|RNA binding|protein kinase activity|protein serine/threonine kinase activity|DNA-dependent protein kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytosol|DNA-dependent protein kinase-DNA ligase 4 complex|double-strand break repair|double-strand break repair via nonhomologous end joining|cellular protein modification process|protein phosphorylation|cellular response to DNA damage stimulus|brain development|heart development|transcription factor binding|intrinsic apoptotic signaling pathway in response to DNA damage|response to gamma radiation|response to activity|membrane|telomere capping|protein ubiquitination|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|enzyme binding|protein domain specific binding|protein destabilization|small-subunit processome|positive regulation of type I interferon production|cellular response to insulin stimulus|protein-containing complex|protein-DNA complex|T cell differentiation in thymus|immunoglobulin V(D)J recombination|T cell receptor V(D)J recombination|small-subunit processome assembly|U3 snoRNA binding|ectopic germ cell programmed cell death|regulation of circadian rhythm|positive regulation of apoptotic process|negative regulation of apoptotic process|innate immune response|positive regulation of lymphocyte differentiation|positive regulation of erythrocyte differentiation|positive regulation of translation|positive regulation of transcription by RNA polymerase II|positive regulation of fibroblast proliferation|rhythmic process|spleen development|thymus development|positive regulation of developmental growth|regulation of smooth muscle cell proliferation|regulation of epithelial cell proliferation|nonhomologous end joining complex|signal transduction involved in mitotic G1 DNA damage checkpoint|double-strand break repair via alternative nonhomologous end joining|protein serine kinase activity|protein threonine kinase activity|regulation of hematopoietic stem cell differentiation|positive regulation of platelet formation|negative regulation of cellular senescence|positive regulation of double-strand break repair via nonhomologous end joining|negative regulation of response to gamma radiation" "hsa03450,hsa04110" Non-homologous end-joining|Cell cycle other PRKG2 268.9092028 234.0931236 303.7252821 1.297454951 0.375684447 0.251604782 1 1.669756718 2.130181778 5593 protein kinase cGMP-dependent 2 "GO:0004672,GO:0004692,GO:0005524,GO:0005829,GO:0006468,GO:0007165,GO:0016324,GO:0030553,GO:0031965,GO:0036289,GO:0042802,GO:0072659,GO:2001226" protein kinase activity|cGMP-dependent protein kinase activity|ATP binding|cytosol|protein phosphorylation|signal transduction|apical plasma membrane|cGMP binding|nuclear membrane|peptidyl-serine autophosphorylation|identical protein binding|protein localization to plasma membrane|negative regulation of chloride transport "hsa04022,hsa04540,hsa04611,hsa04713,hsa04714,hsa04730,hsa04740,hsa04923,hsa04924,hsa04970" cGMP-PKG signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Long-term depression|Olfactory transduction|Regulation of lipolysis in adipocytes|Renin secretion|Salivary secretion PRKRA 769.4903609 683.5519209 855.4288008 1.251446708 0.323596856 0.200844565 1 18.86241453 23.21030372 8575 protein activator of interferon induced protein kinase EIF2AK2 "GO:0003723,GO:0003725,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006955,GO:0008047,GO:0008285,GO:0009615,GO:0010586,GO:0016020,GO:0016032,GO:0019899,GO:0030422,GO:0031054,GO:0034599,GO:0035196,GO:0042473,GO:0042474,GO:0042802,GO:0042803,GO:0048471,GO:0048705,GO:0050790,GO:0050821,GO:0070578,GO:0070883,GO:2001244" RNA binding|double-stranded RNA binding|protein binding|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|immune response|enzyme activator activity|negative regulation of cell population proliferation|response to virus|miRNA metabolic process|membrane|viral process|enzyme binding|production of siRNA involved in RNA interference|pre-miRNA processing|cellular response to oxidative stress|production of miRNAs involved in gene silencing by miRNA|outer ear morphogenesis|middle ear morphogenesis|identical protein binding|protein homodimerization activity|perinuclear region of cytoplasm|skeletal system morphogenesis|regulation of catalytic activity|protein stabilization|RISC-loading complex|pre-miRNA binding|positive regulation of intrinsic apoptotic signaling pathway PRKRIP1 472.3409138 465.0650055 479.616822 1.031289855 0.044449874 0.880087111 1 11.49590764 11.65722529 79706 PRKR interacting protein 1 "GO:0003014,GO:0003725,GO:0004860,GO:0005515,GO:0005681,GO:0005730,GO:0006397,GO:0006469,GO:0008380,GO:0019901,GO:0042326,GO:0070062" renal system process|double-stranded RNA binding|protein kinase inhibitor activity|protein binding|spliceosomal complex|nucleolus|mRNA processing|negative regulation of protein kinase activity|RNA splicing|protein kinase binding|negative regulation of phosphorylation|extracellular exosome PRKX 593.6340338 596.1571548 591.1109129 0.991535383 -0.012263838 0.969978959 1 5.213997322 5.08335218 5613 protein kinase X-linked "GO:0001525,GO:0001935,GO:0004691,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005952,GO:0007155,GO:0007165,GO:0018105,GO:0030099,GO:0030155,GO:0030334,GO:0031589,GO:0043542,GO:0046777,GO:0060562,GO:0060993,GO:0106310,GO:0106311,GO:2000696" angiogenesis|endothelial cell proliferation|cAMP-dependent protein kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cAMP-dependent protein kinase complex|cell adhesion|signal transduction|peptidyl-serine phosphorylation|myeloid cell differentiation|regulation of cell adhesion|regulation of cell migration|cell-substrate adhesion|endothelial cell migration|protein autophosphorylation|epithelial tube morphogenesis|kidney morphogenesis|protein serine kinase activity|protein threonine kinase activity|regulation of epithelial cell differentiation involved in kidney development PRLR 24.25661184 31.21241648 17.30080721 0.554292463 -0.851280704 0.286291334 1 0.130228231 0.070976617 5618 prolactin receptor "GO:0004896,GO:0004923,GO:0004924,GO:0004925,GO:0005127,GO:0005515,GO:0005576,GO:0005886,GO:0006694,GO:0007171,GO:0007566,GO:0007595,GO:0008284,GO:0009897,GO:0009986,GO:0016021,GO:0017046,GO:0019221,GO:0019955,GO:0031904,GO:0038161,GO:0038165,GO:0042976,GO:0043066,GO:0043235,GO:0046872,GO:0048861,GO:0060397,GO:0120162" cytokine receptor activity|leukemia inhibitory factor receptor activity|oncostatin-M receptor activity|prolactin receptor activity|ciliary neurotrophic factor receptor binding|protein binding|extracellular region|plasma membrane|steroid biosynthetic process|activation of transmembrane receptor protein tyrosine kinase activity|embryo implantation|lactation|positive regulation of cell population proliferation|external side of plasma membrane|cell surface|integral component of membrane|peptide hormone binding|cytokine-mediated signaling pathway|cytokine binding|endosome lumen|prolactin signaling pathway|oncostatin-M-mediated signaling pathway|activation of Janus kinase activity|negative regulation of apoptotic process|receptor complex|metal ion binding|leukemia inhibitory factor signaling pathway|growth hormone receptor signaling pathway via JAK-STAT|positive regulation of cold-induced thermogenesis "hsa04060,hsa04080,hsa04151,hsa04630,hsa04917" Cytokine-cytokine receptor interaction|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|JAK-STAT signaling pathway|Prolactin signaling pathway PRMT1 3285.295071 3319.9607 3250.629443 0.979116844 -0.030447059 0.899037813 1 102.9518888 99.11514476 3276 protein arginine methyltransferase 1 "GO:0001701,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006479,GO:0006977,GO:0007166,GO:0008168,GO:0008170,GO:0008276,GO:0008284,GO:0008327,GO:0016274,GO:0016571,GO:0018216,GO:0019899,GO:0019919,GO:0031175,GO:0034709,GO:0035241,GO:0035242,GO:0042054,GO:0042802,GO:0043985,GO:0044020,GO:0045648,GO:0045652,GO:0045653,GO:0046985,GO:0048273,GO:0051260,GO:1900745,GO:1904047" "in utero embryonic development|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein methylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|cell surface receptor signaling pathway|methyltransferase activity|N-methyltransferase activity|protein methyltransferase activity|positive regulation of cell population proliferation|methyl-CpG binding|protein-arginine N-methyltransferase activity|histone methylation|peptidyl-arginine methylation|enzyme binding|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|neuron projection development|methylosome|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N asymmetric methyltransferase activity|histone methyltransferase activity|identical protein binding|histone H4-R3 methylation|histone methyltransferase activity (H4-R3 specific)|positive regulation of erythrocyte differentiation|regulation of megakaryocyte differentiation|negative regulation of megakaryocyte differentiation|positive regulation of hemoglobin biosynthetic process|mitogen-activated protein kinase p38 binding|protein homooligomerization|positive regulation of p38MAPK cascade|S-adenosyl-L-methionine binding" "hsa04068,hsa04922" FoxO signaling pathway|Glucagon signaling pathway PRMT2 1213.036225 1149.65734 1276.41511 1.110257 0.150893667 0.534198386 1 5.389117196 5.883182582 3275 protein arginine methyltransferase 2 "GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006479,GO:0007165,GO:0008469,GO:0016274,GO:0016571,GO:0019919,GO:0030331,GO:0032088,GO:0033142,GO:0034969,GO:0035242,GO:0042054,GO:0042803,GO:0042974,GO:0042975,GO:0043065,GO:0044877,GO:0045892,GO:0045893,GO:0046966,GO:0048588,GO:0050681,GO:0060765,GO:2000134" "transcription coactivator activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|protein methylation|signal transduction|histone-arginine N-methyltransferase activity|protein-arginine N-methyltransferase activity|histone methylation|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|estrogen receptor binding|negative regulation of NF-kappaB transcription factor activity|progesterone receptor binding|histone arginine methylation|protein-arginine omega-N asymmetric methyltransferase activity|histone methyltransferase activity|protein homodimerization activity|retinoic acid receptor binding|peroxisome proliferator activated receptor binding|positive regulation of apoptotic process|protein-containing complex binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|thyroid hormone receptor binding|developmental cell growth|androgen receptor binding|regulation of androgen receptor signaling pathway|negative regulation of G1/S transition of mitotic cell cycle" PRMT3 550.9764503 611.763363 490.1895376 0.801273118 -0.319634018 0.232343964 1 10.26365492 8.086373437 10196 protein arginine methyltransferase 3 "GO:0005515,GO:0005737,GO:0005829,GO:0006479,GO:0008168,GO:0016274,GO:0031397,GO:0035246,GO:0043022,GO:0046872" protein binding|cytoplasm|cytosol|protein methylation|methyltransferase activity|protein-arginine N-methyltransferase activity|negative regulation of protein ubiquitination|peptidyl-arginine N-methylation|ribosome binding|metal ion binding PRMT5 3119.269799 2985.987843 3252.551755 1.0892716 0.123363722 0.603061386 1 66.70434624 71.44329748 10419 protein arginine methyltransferase 5 "GO:0000387,GO:0002039,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006353,GO:0006355,GO:0007088,GO:0008168,GO:0008327,GO:0008469,GO:0016274,GO:0018216,GO:0019918,GO:0032922,GO:0034709,GO:0034969,GO:0035097,GO:0035243,GO:0035246,GO:0042118,GO:0042802,GO:0043021,GO:0043985,GO:0044020,GO:0044030,GO:0045596,GO:0045892,GO:0046982,GO:0048714,GO:0070372,GO:0070888,GO:0090161,GO:0097421,GO:1901796,GO:1904992" "spliceosomal snRNP assembly|p53 binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|DNA-templated transcription, termination|regulation of transcription, DNA-templated|regulation of mitotic nuclear division|methyltransferase activity|methyl-CpG binding|histone-arginine N-methyltransferase activity|protein-arginine N-methyltransferase activity|peptidyl-arginine methylation|peptidyl-arginine methylation, to symmetrical-dimethyl arginine|circadian regulation of gene expression|methylosome|histone arginine methylation|histone methyltransferase complex|protein-arginine omega-N symmetric methyltransferase activity|peptidyl-arginine N-methylation|endothelial cell activation|identical protein binding|ribonucleoprotein complex binding|histone H4-R3 methylation|histone methyltransferase activity (H4-R3 specific)|regulation of DNA methylation|negative regulation of cell differentiation|negative regulation of transcription, DNA-templated|protein heterodimerization activity|positive regulation of oligodendrocyte differentiation|regulation of ERK1 and ERK2 cascade|E-box binding|Golgi ribbon formation|liver regeneration|regulation of signal transduction by p53 class mediator|positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" hsa03013 RNA transport PRMT6 379.5050757 475.4691444 283.541007 0.596339448 -0.745794321 0.011090692 0.6241367 9.681386631 5.676782849 55170 protein arginine methyltransferase 6 "GO:0000122,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006284,GO:0008469,GO:0010821,GO:0016032,GO:0016274,GO:0016571,GO:0019919,GO:0031064,GO:0034970,GO:0035241,GO:0035242,GO:0042054,GO:0042393,GO:0043985,GO:0044020,GO:0045652,GO:0045892,GO:0051572,GO:0070611,GO:0070612,GO:0090398,GO:1901796" "negative regulation of transcription by RNA polymerase II|chromatin binding|protein binding|nucleus|nucleoplasm|nucleolus|base-excision repair|histone-arginine N-methyltransferase activity|regulation of mitochondrion organization|viral process|protein-arginine N-methyltransferase activity|histone methylation|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|negative regulation of histone deacetylation|histone H3-R2 methylation|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N asymmetric methyltransferase activity|histone methyltransferase activity|histone binding|histone H4-R3 methylation|histone methyltransferase activity (H4-R3 specific)|regulation of megakaryocyte differentiation|negative regulation of transcription, DNA-templated|negative regulation of histone H3-K4 methylation|histone methyltransferase activity (H3-R2 specific)|histone methyltransferase activity (H2A-R3 specific)|cellular senescence|regulation of signal transduction by p53 class mediator" PRMT7 443.5559249 441.1354862 445.9763636 1.010973675 0.015745431 0.964261658 1 3.420396648 3.400067176 54496 protein arginine methyltransferase 7 "GO:0000387,GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006349,GO:0008469,GO:0008757,GO:0016277,GO:0016571,GO:0018216,GO:0019918,GO:0030154,GO:0034969,GO:0035241,GO:0035243,GO:0042393,GO:0043021,GO:0043046,GO:0043393,GO:0043985,GO:0044020" "spliceosomal snRNP assembly|fibrillar center|protein binding|nucleus|nucleoplasm|cytosol|regulation of gene expression by genetic imprinting|histone-arginine N-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|[myelin basic protein]-arginine N-methyltransferase activity|histone methylation|peptidyl-arginine methylation|peptidyl-arginine methylation, to symmetrical-dimethyl arginine|cell differentiation|histone arginine methylation|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|histone binding|ribonucleoprotein complex binding|DNA methylation involved in gamete generation|regulation of protein binding|histone H4-R3 methylation|histone methyltransferase activity (H4-R3 specific)" PRMT9 435.3860993 441.1354862 429.6367123 0.973933691 -0.038104543 0.901035328 1 3.750014356 3.591149609 90826 protein arginine methyltransferase 9 "GO:0005515,GO:0005737,GO:0006397,GO:0016274,GO:0019918,GO:0035241,GO:0035243" "protein binding|cytoplasm|mRNA processing|protein-arginine N-methyltransferase activity|peptidyl-arginine methylation, to symmetrical-dimethyl arginine|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity" PRNP 7134.87555 7020.71288 7249.03822 1.032521675 0.046172067 0.850813683 1 154.1269202 156.4764036 5621 prion protein "GO:0001540,GO:0001933,GO:0002020,GO:0005507,GO:0005509,GO:0005515,GO:0005539,GO:0005634,GO:0005737,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0006878,GO:0006979,GO:0007050,GO:0007611,GO:0007616,GO:0008017,GO:0009986,GO:0010951,GO:0010955,GO:0014069,GO:0015631,GO:0016234,GO:0019828,GO:0019898,GO:0030425,GO:0031362,GO:0031648,GO:0031802,GO:0031805,GO:0031965,GO:0032689,GO:0032700,GO:0032703,GO:0035584,GO:0038023,GO:0042802,GO:0043231,GO:0043433,GO:0043525,GO:0044877,GO:0045121,GO:0046007,GO:0050730,GO:0050731,GO:0050860,GO:0051260,GO:0061098,GO:0070062,GO:0070885,GO:0071280,GO:0090314,GO:0090647,GO:0097062,GO:0098794,GO:1900449,GO:1901216,GO:1902430,GO:1902938,GO:1902951,GO:1902992,GO:1903136,GO:1904645,GO:1904646,GO:1905664,GO:1990535" amyloid-beta binding|negative regulation of protein phosphorylation|protease binding|copper ion binding|calcium ion binding|protein binding|glycosaminoglycan binding|nucleus|cytoplasm|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|cellular copper ion homeostasis|response to oxidative stress|cell cycle arrest|learning or memory|long-term memory|microtubule binding|cell surface|negative regulation of endopeptidase activity|negative regulation of protein processing|postsynaptic density|tubulin binding|inclusion body|aspartic-type endopeptidase inhibitor activity|extrinsic component of membrane|dendrite|anchored component of external side of plasma membrane|protein destabilization|type 5 metabotropic glutamate receptor binding|type 8 metabotropic glutamate receptor binding|nuclear membrane|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-2 production|calcium-mediated signaling using intracellular calcium source|signaling receptor activity|identical protein binding|intracellular membrane-bounded organelle|negative regulation of DNA-binding transcription factor activity|positive regulation of neuron apoptotic process|protein-containing complex binding|membrane raft|negative regulation of activated T cell proliferation|regulation of peptidyl-tyrosine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of T cell receptor signaling pathway|protein homooligomerization|positive regulation of protein tyrosine kinase activity|extracellular exosome|negative regulation of calcineurin-NFAT signaling cascade|cellular response to copper ion|positive regulation of protein targeting to membrane|modulation of age-related behavioral decline|dendritic spine maintenance|postsynapse|regulation of glutamate receptor signaling pathway|positive regulation of neuron death|negative regulation of amyloid-beta formation|regulation of intracellular calcium activated chloride channel activity|negative regulation of dendritic spine maintenance|negative regulation of amyloid precursor protein catabolic process|cuprous ion binding|response to amyloid-beta|cellular response to amyloid-beta|regulation of calcium ion import across plasma membrane|neuron projection maintenance "hsa04216,hsa05020,hsa05022" Ferroptosis|Prion disease|Pathways of neurodegeneration - multiple diseases PROB1 31.8269726 28.09117483 35.56277037 1.265976613 0.340250754 0.659887996 1 0.3321902 0.413507773 389333 proline rich basic protein 1 GO:0005654 nucleoplasm PROC 6.926236509 5.202069413 8.650403604 1.662877389 0.733681797 0.660649523 1 0.121872205 0.199267318 5624 "protein C, inactivator of coagulation factors Va and VIIIa" "GO:0004252,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0005788,GO:0005794,GO:0005796,GO:0006508,GO:0006888,GO:0007596,GO:0030195,GO:0043066,GO:0043687,GO:0044267,GO:0050728,GO:0050819,GO:1903142" serine-type endopeptidase activity|calcium ion binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|Golgi apparatus|Golgi lumen|proteolysis|endoplasmic reticulum to Golgi vesicle-mediated transport|blood coagulation|negative regulation of blood coagulation|negative regulation of apoptotic process|post-translational protein modification|cellular protein metabolic process|negative regulation of inflammatory response|negative regulation of coagulation|positive regulation of establishment of endothelial barrier hsa04610 Complement and coagulation cascades PROCA1 63.44573955 75.95021343 50.94126567 0.67071919 -0.576219214 0.297857942 1 1.476082775 0.973470115 147011 protein interacting with cyclin A1 "GO:0004623,GO:0006644,GO:0030332,GO:0050482" phospholipase A2 activity|phospholipid metabolic process|cyclin binding|arachidonic acid secretion PROCR 2245.994717 2252.496056 2239.493377 0.994227436 -0.00835218 0.973900791 1 83.13386901 81.27087109 10544 protein C receptor "GO:0005515,GO:0005576,GO:0005615,GO:0005813,GO:0005886,GO:0005887,GO:0005925,GO:0007596,GO:0009986,GO:0038023,GO:0048471,GO:0050819,GO:0070062" protein binding|extracellular region|extracellular space|centrosome|plasma membrane|integral component of plasma membrane|focal adhesion|blood coagulation|cell surface|signaling receptor activity|perinuclear region of cytoplasm|negative regulation of coagulation|extracellular exosome hsa04610 Complement and coagulation cascades PROM2 5.643018428 9.363724944 1.922311912 0.205293505 -2.284240111 0.166157707 1 0.100791608 0.020345612 150696 prominin 2 "GO:0001934,GO:0005515,GO:0005887,GO:0005902,GO:0005929,GO:0009986,GO:0015485,GO:0016323,GO:0016324,GO:0031346,GO:0031410,GO:0031528,GO:0042995,GO:0043087,GO:0044393,GO:0045121,GO:0048550,GO:0060170,GO:0070062,GO:0071914,GO:2000369,GO:2001287" positive regulation of protein phosphorylation|protein binding|integral component of plasma membrane|microvillus|cilium|cell surface|cholesterol binding|basolateral plasma membrane|apical plasma membrane|positive regulation of cell projection organization|cytoplasmic vesicle|microvillus membrane|cell projection|regulation of GTPase activity|microspike|membrane raft|negative regulation of pinocytosis|ciliary membrane|extracellular exosome|prominosome|regulation of clathrin-dependent endocytosis|negative regulation of caveolin-mediated endocytosis PRORP 1241.974699 1190.233482 1293.715917 1.086942971 0.120276248 0.620242128 1 21.36581681 22.83481184 9692 protein only RNase P catalytic subunit "GO:0001682,GO:0004526,GO:0005654,GO:0005739,GO:0005759,GO:0030678,GO:0046872,GO:0070901,GO:0090502,GO:0090646,GO:0097745" "tRNA 5'-leader removal|ribonuclease P activity|nucleoplasm|mitochondrion|mitochondrial matrix|mitochondrial ribonuclease P complex|metal ion binding|mitochondrial tRNA methylation|RNA phosphodiester bond hydrolysis, endonucleolytic|mitochondrial tRNA processing|mitochondrial tRNA 5'-end processing" PROS1 708.72933 703.3197847 714.1388753 1.01538289 0.022023854 0.937271462 1 10.82320769 10.80580215 5627 protein S "GO:0000139,GO:0002576,GO:0004866,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005789,GO:0005796,GO:0005886,GO:0006888,GO:0007596,GO:0010951,GO:0030449,GO:0031093,GO:0042730,GO:0050900,GO:0070062,GO:0072562" Golgi membrane|platelet degranulation|endopeptidase inhibitor activity|calcium ion binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum membrane|Golgi lumen|plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|blood coagulation|negative regulation of endopeptidase activity|regulation of complement activation|platelet alpha granule lumen|fibrinolysis|leukocyte migration|extracellular exosome|blood microparticle hsa04610 Complement and coagulation cascades PROSER1 1159.869478 1305.719423 1014.019534 0.776598338 -0.364759475 0.132896764 1 15.47154658 11.81411964 80209 proline and serine rich 1 PROSER2 1356.104423 1208.960932 1503.247915 1.243421417 0.314315334 0.190378096 1 14.49236814 17.71857861 254427 proline and serine rich 2 GO:0005515 protein binding PROSER3 240.673989 237.2143652 244.1336128 1.029168754 0.041479563 0.915499179 1 2.565287678 2.595935193 148137 proline and serine rich 3 GO:0005515 protein binding PROX1 24.57867397 27.05076095 22.10658699 0.817226067 -0.291192872 0.749734793 1 0.151851204 0.122020171 5629 prospero homeobox 1 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0001709,GO:0001822,GO:0001889,GO:0001938,GO:0001946,GO:0002088,GO:0002194,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0007420,GO:0007623,GO:0008284,GO:0008285,GO:0010468,GO:0010595,GO:0016922,GO:0021516,GO:0021542,GO:0021707,GO:0021915,GO:0030240,GO:0030324,GO:0030910,GO:0031016,GO:0031667,GO:0042752,GO:0043049,GO:0043433,GO:0045071,GO:0045737,GO:0045787,GO:0045892,GO:0045944,GO:0046619,GO:0048845,GO:0050692,GO:0050693,GO:0055005,GO:0055009,GO:0055010,GO:0060042,GO:0060059,GO:0060214,GO:0060298,GO:0060412,GO:0060414,GO:0060421,GO:0060836,GO:0060838,GO:0061114,GO:0070309,GO:0070365,GO:0070858,GO:0072574,GO:0090425,GO:0097150,GO:1901978,GO:1990837,GO:2000179,GO:2000979" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|cell fate determination|kidney development|liver development|positive regulation of endothelial cell proliferation|lymphangiogenesis|lens development in camera-type eye|hepatocyte cell migration|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|brain development|circadian rhythm|positive regulation of cell population proliferation|negative regulation of cell population proliferation|regulation of gene expression|positive regulation of endothelial cell migration|nuclear receptor binding|dorsal spinal cord development|dentate gyrus development|cerebellar granule cell differentiation|neural tube development|skeletal muscle thin filament assembly|lung development|olfactory placode formation|pancreas development|response to nutrient levels|regulation of circadian rhythm|otic placode formation|negative regulation of DNA-binding transcription factor activity|negative regulation of viral genome replication|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|optic placode formation involved in camera-type eye formation|venous blood vessel morphogenesis|DNA binding domain binding|LBD domain binding|ventricular cardiac myofibril assembly|atrial cardiac muscle tissue morphogenesis|ventricular cardiac muscle tissue morphogenesis|retina morphogenesis in camera-type eye|embryonic retina morphogenesis in camera-type eye|endocardium formation|positive regulation of sarcomere organization|ventricular septum morphogenesis|aorta smooth muscle tissue morphogenesis|positive regulation of heart growth|lymphatic endothelial cell differentiation|lymphatic endothelial cell fate commitment|branching involved in pancreas morphogenesis|lens fiber cell morphogenesis|hepatocyte differentiation|negative regulation of bile acid biosynthetic process|hepatocyte proliferation|acinar cell differentiation|neuronal stem cell population maintenance|positive regulation of cell cycle checkpoint|sequence-specific double-stranded DNA binding|positive regulation of neural precursor cell proliferation|positive regulation of forebrain neuron differentiation" PRPF18 283.1629959 242.4164347 323.9095572 1.336169957 0.418103527 0.194148487 1 6.651578188 8.738916342 8559 pre-mRNA processing factor 18 "GO:0000350,GO:0005515,GO:0005634,GO:0005681,GO:0005682,GO:0006397,GO:0008380,GO:0016607,GO:0046540,GO:0071021,GO:0071048" generation of catalytic spliceosome for second transesterification step|protein binding|nucleus|spliceosomal complex|U5 snRNP|mRNA processing|RNA splicing|nuclear speck|U4/U6 x U5 tri-snRNP complex|U2-type post-spliceosomal complex|nuclear retention of unspliced pre-mRNA at the site of transcription hsa03040 Spliceosome PRPF19 2909.638421 3033.846882 2785.42996 0.918118174 -0.123248235 0.603098665 1 69.28148571 62.54418755 27339 pre-mRNA processing factor 19 "GO:0000209,GO:0000244,GO:0000245,GO:0000349,GO:0000398,GO:0000974,GO:0001833,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005662,GO:0005737,GO:0005811,GO:0005819,GO:0006283,GO:0006303,GO:0008610,GO:0010498,GO:0016020,GO:0016607,GO:0034450,GO:0034613,GO:0035861,GO:0042802,GO:0045666,GO:0048026,GO:0048711,GO:0061630,GO:0070534,GO:0071006,GO:0071007,GO:0071013,GO:0072422" "protein polyubiquitination|spliceosomal tri-snRNP complex assembly|spliceosomal complex assembly|generation of catalytic spliceosome for first transesterification step|mRNA splicing, via spliceosome|Prp19 complex|inner cell mass cell proliferation|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|DNA replication factor A complex|cytoplasm|lipid droplet|spindle|transcription-coupled nucleotide-excision repair|double-strand break repair via nonhomologous end joining|lipid biosynthetic process|proteasomal protein catabolic process|membrane|nuclear speck|ubiquitin-ubiquitin ligase activity|cellular protein localization|site of double-strand break|identical protein binding|positive regulation of neuron differentiation|positive regulation of mRNA splicing, via spliceosome|positive regulation of astrocyte differentiation|ubiquitin protein ligase activity|protein K63-linked ubiquitination|U2-type catalytic step 1 spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|signal transduction involved in DNA damage checkpoint" "hsa03040,hsa04120" Spliceosome|Ubiquitin mediated proteolysis PRPF3 1029.981289 1037.292641 1022.669937 0.98590301 -0.020482369 0.937621359 1 20.20379627 19.58566635 9129 pre-mRNA processing factor 3 "GO:0000244,GO:0000375,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005829,GO:0006397,GO:0008380,GO:0015030,GO:0016607,GO:0042802,GO:0046540,GO:0071005" "spliceosomal tri-snRNP complex assembly|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytosol|mRNA processing|RNA splicing|Cajal body|nuclear speck|identical protein binding|U4/U6 x U5 tri-snRNP complex|U2-type precatalytic spliceosome" hsa03040 Spliceosome PRPF31 944.2559698 893.7155252 994.7964145 1.113101861 0.154585621 0.533477094 1 24.95863684 27.31661925 26121 pre-mRNA processing factor 31 "GO:0000244,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005684,GO:0005687,GO:0005690,GO:0015030,GO:0016607,GO:0030621,GO:0030622,GO:0042802,GO:0043021,GO:0046540,GO:0048254,GO:0070990,GO:0071005,GO:0071011,GO:0071166,GO:0071339,GO:0097526" "spliceosomal tri-snRNP complex assembly|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U2-type spliceosomal complex|U4 snRNP|U4atac snRNP|Cajal body|nuclear speck|U4 snRNA binding|U4atac snRNA binding|identical protein binding|ribonucleoprotein complex binding|U4/U6 x U5 tri-snRNP complex|snoRNA localization|snRNP binding|U2-type precatalytic spliceosome|precatalytic spliceosome|ribonucleoprotein complex localization|MLL1 complex|spliceosomal tri-snRNP complex" hsa03040 Spliceosome PRPF38A 976.9296275 1007.120638 946.7386167 0.940044897 -0.089198433 0.720247335 1 10.15649612 9.387796821 84950 pre-mRNA processing factor 38A "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0071005,GO:0071011" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U2-type precatalytic spliceosome|precatalytic spliceosome" hsa03040 Spliceosome PRPF38B 1020.503708 1002.958983 1038.048432 1.034985927 0.049611151 0.843451154 1 13.78117342 14.02464319 55119 pre-mRNA processing factor 38B "GO:0003723,GO:0006397,GO:0008380,GO:0071011" RNA binding|mRNA processing|RNA splicing|precatalytic spliceosome hsa03040 Spliceosome PRPF39 701.5105995 728.2897178 674.7314811 0.92646026 -0.110199001 0.670593789 1 11.00438383 10.02452271 55015 pre-mRNA processing factor 39 "GO:0000243,GO:0000395,GO:0005515,GO:0005685,GO:0071004" commitment complex|mRNA 5'-splice site recognition|protein binding|U1 snRNP|U2-type prespliceosome PRPF4 1449.518376 1453.458194 1445.578558 0.994578698 -0.007842564 0.977051906 1 26.3927841 25.81044765 9128 pre-mRNA processing factor 4 "GO:0000375,GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0006396,GO:0008380,GO:0015030,GO:0016607,GO:0017070,GO:0030621,GO:0046540,GO:0071001,GO:0071005,GO:0097525" "RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|spliceosomal complex|RNA processing|RNA splicing|Cajal body|nuclear speck|U6 snRNA binding|U4 snRNA binding|U4/U6 x U5 tri-snRNP complex|U4/U6 snRNP|U2-type precatalytic spliceosome|spliceosomal snRNP complex" hsa03040 Spliceosome PRPF40A 3846.39507 3654.97397 4037.816171 1.104745534 0.143714099 0.546093586 1 22.6865833 24.64350787 55660 pre-mRNA processing factor 40 homolog A "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005685,GO:0007010,GO:0007049,GO:0008360,GO:0016020,GO:0016363,GO:0016477,GO:0016607,GO:0032465,GO:0045292,GO:0051301,GO:0071004" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|U1 snRNP|cytoskeleton organization|cell cycle|regulation of cell shape|membrane|nuclear matrix|cell migration|nuclear speck|regulation of cytokinesis|mRNA cis splicing, via spliceosome|cell division|U2-type prespliceosome" hsa03040 Spliceosome PRPF40B 315.4107959 319.407062 311.4145297 0.974976971 -0.036559952 0.916674772 1 3.337804553 3.199826561 25766 pre-mRNA processing factor 40 homolog B "GO:0000398,GO:0003723,GO:0005515,GO:0005685,GO:0016607,GO:0045292,GO:0071004" "mRNA splicing, via spliceosome|RNA binding|protein binding|U1 snRNP|nuclear speck|mRNA cis splicing, via spliceosome|U2-type prespliceosome" hsa03040 Spliceosome PRPF4B 1737.689712 1789.511878 1685.867547 0.942082345 -0.086074927 0.71845696 1 14.9714626 13.86833339 8899 pre-mRNA processing factor 4B "GO:0000398,GO:0003723,GO:0004672,GO:0005515,GO:0005524,GO:0005634,GO:0005694,GO:0006468,GO:0008380,GO:0016607,GO:0045292,GO:0071013,GO:0106310,GO:0106311" "mRNA splicing, via spliceosome|RNA binding|protein kinase activity|protein binding|ATP binding|nucleus|chromosome|protein phosphorylation|RNA splicing|nuclear speck|mRNA cis splicing, via spliceosome|catalytic step 2 spliceosome|protein serine kinase activity|protein threonine kinase activity" PRPF6 3217.460578 3103.554612 3331.366543 1.073403552 0.102192567 0.666994835 1 54.35871531 57.3724493 24148 pre-mRNA processing factor 6 "GO:0000244,GO:0000245,GO:0000375,GO:0000398,GO:0003713,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0006403,GO:0008380,GO:0016020,GO:0016607,GO:0043021,GO:0045944,GO:0046540,GO:0050681,GO:0071005,GO:0071013" "spliceosomal tri-snRNP complex assembly|spliceosomal complex assembly|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|transcription coactivator activity|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U5 snRNP|RNA localization|RNA splicing|membrane|nuclear speck|ribonucleoprotein complex binding|positive regulation of transcription by RNA polymerase II|U4/U6 x U5 tri-snRNP complex|androgen receptor binding|U2-type precatalytic spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome PRPF8 10904.76963 12288.32837 9521.2109 0.774817421 -0.368071702 0.146615738 1 89.92259701 68.5077015 10594 pre-mRNA processing factor 8 "GO:0000244,GO:0000375,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005682,GO:0006397,GO:0006508,GO:0008237,GO:0008380,GO:0016020,GO:0016607,GO:0017070,GO:0030619,GO:0030620,GO:0030623,GO:0046540,GO:0070122,GO:0070530,GO:0071005,GO:0071006,GO:0071007,GO:0071013,GO:0071222,GO:0071356,GO:0097157" "spliceosomal tri-snRNP complex assembly|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U5 snRNP|mRNA processing|proteolysis|metallopeptidase activity|RNA splicing|membrane|nuclear speck|U6 snRNA binding|U1 snRNA binding|U2 snRNA binding|U5 snRNA binding|U4/U6 x U5 tri-snRNP complex|isopeptidase activity|K63-linked polyubiquitin modification-dependent protein binding|U2-type precatalytic spliceosome|U2-type catalytic step 1 spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|cellular response to lipopolysaccharide|cellular response to tumor necrosis factor|pre-mRNA intronic binding" hsa03040 Spliceosome PRPH 5.806564699 1.040413883 10.57271552 10.16202849 3.345116509 0.064182317 1 0.030541791 0.30517299 5630 peripherin "GO:0005198,GO:0005515,GO:0005737,GO:0005882,GO:0016020,GO:0030424,GO:0043204,GO:0045098,GO:0045104,GO:0070062" structural molecule activity|protein binding|cytoplasm|intermediate filament|membrane|axon|perikaryon|type III intermediate filament|intermediate filament cytoskeleton organization|extracellular exosome "hsa05014,hsa05022" Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases PRPS1 1596.614252 1555.418755 1637.809749 1.052970298 0.074464741 0.756360656 1 40.10137207 41.51896623 5631 phosphoribosyl pyrophosphate synthetase 1 "GO:0000287,GO:0002189,GO:0004749,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006015,GO:0006144,GO:0006164,GO:0006221,GO:0007399,GO:0009116,GO:0009156,GO:0016301,GO:0016310,GO:0034418,GO:0042802,GO:0042803,GO:0046101" magnesium ion binding|ribose phosphate diphosphokinase complex|ribose phosphate diphosphokinase activity|protein binding|ATP binding|cytoplasm|cytosol|5-phosphoribose 1-diphosphate biosynthetic process|purine nucleobase metabolic process|purine nucleotide biosynthetic process|pyrimidine nucleotide biosynthetic process|nervous system development|nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process|kinase activity|phosphorylation|urate biosynthetic process|identical protein binding|protein homodimerization activity|hypoxanthine biosynthetic process "hsa00030,hsa00230" Pentose phosphate pathway|Purine metabolism PRPS2 1984.656489 1914.361544 2054.951434 1.073439571 0.102240977 0.666956836 1 41.37948852 43.67509895 5634 phosphoribosyl pyrophosphate synthetase 2 "GO:0000287,GO:0002189,GO:0004749,GO:0005515,GO:0005524,GO:0005737,GO:0006015,GO:0006139,GO:0006164,GO:0006167,GO:0009116,GO:0016208,GO:0016301,GO:0016310,GO:0019003,GO:0030246,GO:0031100,GO:0042802,GO:0042803,GO:0043531" magnesium ion binding|ribose phosphate diphosphokinase complex|ribose phosphate diphosphokinase activity|protein binding|ATP binding|cytoplasm|5-phosphoribose 1-diphosphate biosynthetic process|nucleobase-containing compound metabolic process|purine nucleotide biosynthetic process|AMP biosynthetic process|nucleoside metabolic process|AMP binding|kinase activity|phosphorylation|GDP binding|carbohydrate binding|animal organ regeneration|identical protein binding|protein homodimerization activity|ADP binding "hsa00030,hsa00230" Pentose phosphate pathway|Purine metabolism PRPSAP1 1651.251686 1526.287166 1776.216207 1.163749684 0.218780776 0.357739503 1 23.16040399 26.50189233 5635 phosphoribosyl pyrophosphate synthetase associated protein 1 "GO:0000287,GO:0002189,GO:0004749,GO:0004857,GO:0005515,GO:0005737,GO:0006015,GO:0006139,GO:0006164,GO:0042802,GO:0043086" magnesium ion binding|ribose phosphate diphosphokinase complex|ribose phosphate diphosphokinase activity|enzyme inhibitor activity|protein binding|cytoplasm|5-phosphoribose 1-diphosphate biosynthetic process|nucleobase-containing compound metabolic process|purine nucleotide biosynthetic process|identical protein binding|negative regulation of catalytic activity PRPSAP2 445.7701164 511.8836303 379.6566026 0.741685376 -0.431120772 0.124815516 1 9.995714799 7.289617667 5636 phosphoribosyl pyrophosphate synthetase associated protein 2 "GO:0000287,GO:0002189,GO:0004749,GO:0004857,GO:0005515,GO:0005737,GO:0006015,GO:0006139,GO:0006164,GO:0009116,GO:0042802,GO:0043086" magnesium ion binding|ribose phosphate diphosphokinase complex|ribose phosphate diphosphokinase activity|enzyme inhibitor activity|protein binding|cytoplasm|5-phosphoribose 1-diphosphate biosynthetic process|nucleobase-containing compound metabolic process|purine nucleotide biosynthetic process|nucleoside metabolic process|identical protein binding|negative regulation of catalytic activity PRR11 8041.433931 8640.637295 7442.230567 0.861305748 -0.215402636 0.382812126 1 69.00118684 58.43661954 55771 proline rich 11 "GO:0005634,GO:0005737,GO:0007050,GO:0016020,GO:0051726" nucleus|cytoplasm|cell cycle arrest|membrane|regulation of cell cycle PRR12 600.0249722 637.7737101 562.2762343 0.881623412 -0.181765559 0.491710833 1 4.589645459 3.978628888 57479 proline rich 12 "GO:0005634,GO:0014069,GO:0043005" nucleus|postsynaptic density|neuron projection PRR13 2432.542032 2443.93221 2421.151853 0.99067881 -0.013510701 0.956290557 1 118.0345433 114.9775833 54458 proline rich 13 "GO:0005515,GO:0005654,GO:0005829" protein binding|nucleoplasm|cytosol PRR14 579.5783856 593.0359131 566.1208581 0.954614797 -0.067009395 0.805827262 1 15.02099513 14.09931605 78994 proline rich 14 "GO:0005515,GO:0005652,GO:0005654,GO:0005694,GO:0007517" protein binding|nuclear lamina|nucleoplasm|chromosome|muscle organ development PRR14L 1188.060033 1314.042734 1062.077331 0.808251744 -0.307123379 0.204987443 1 6.477144693 5.147560124 253143 proline rich 14 like PRR15 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.077153743 0.046722346 222171 proline rich 15 "GO:0005515,GO:0007275" protein binding|multicellular organism development PRR16 342.4319887 347.4982368 337.3657406 0.970841589 -0.042692182 0.897430412 1 4.476307561 4.273064711 51334 proline rich 16 "GO:0005515,GO:0045727,GO:0045793" protein binding|positive regulation of translation|positive regulation of cell size PRR19 21.09574123 23.9295193 18.26196316 0.76315629 -0.389949553 0.676048262 1 0.601825855 0.451601638 284338 proline rich 19 GO:0005515 protein binding PRR22 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.040440624 0.110204164 163154 proline rich 22 PRR29 30.54375452 32.25283036 28.83467868 0.894020102 -0.161620825 0.865545159 1 0.517988046 0.455342513 92340 proline rich 29 PRR3 284.0694317 278.8309205 289.3079428 1.037574822 0.053215376 0.879298896 1 6.121223266 6.244947956 80742 proline rich 3 "GO:0003723,GO:0005515,GO:0046872" RNA binding|protein binding|metal ion binding PRR36 20.57553429 22.88910542 18.26196316 0.797845212 -0.325819215 0.74151566 1 0.273460821 0.21452847 80164 proline rich 36 PRR4 20.49627636 20.80827765 20.18427508 0.97001181 -0.043925782 1 1 1.972468089 1.881300568 11272 proline rich 4 "GO:0001895,GO:0005515,GO:0005615,GO:0007601" retina homeostasis|protein binding|extracellular space|visual perception PRR5L 160.536968 139.4154603 181.6584757 1.303000939 0.381838124 0.337200396 1 1.814276245 2.324445251 79899 proline rich 5 like "GO:0001933,GO:0001934,GO:0005515,GO:0009968,GO:0010762,GO:0014068,GO:0031625,GO:0031932,GO:0034599,GO:0038203,GO:0061014,GO:0090316" negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|protein binding|negative regulation of signal transduction|regulation of fibroblast migration|positive regulation of phosphatidylinositol 3-kinase signaling|ubiquitin protein ligase binding|TORC2 complex|cellular response to oxidative stress|TORC2 signaling|positive regulation of mRNA catabolic process|positive regulation of intracellular protein transport PRR7 289.3060996 302.7604398 275.8517594 0.911122204 -0.134283526 0.681544864 1 1.772268095 1.587732112 80758 "proline rich 7, synaptic" "GO:0002250,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0010942,GO:0016021,GO:0030425,GO:0031397,GO:0033077,GO:0036041,GO:0043065,GO:0044389,GO:0044877,GO:0046632,GO:0048471,GO:0098839,GO:0098978,GO:0099092,GO:0099527,GO:1990782,GO:2001269" "adaptive immune response|protein binding|nucleoplasm|cytosol|plasma membrane|positive regulation of cell death|integral component of membrane|dendrite|negative regulation of protein ubiquitination|T cell differentiation in thymus|long-chain fatty acid binding|positive regulation of apoptotic process|ubiquitin-like protein ligase binding|protein-containing complex binding|alpha-beta T cell differentiation|perinuclear region of cytoplasm|postsynaptic density membrane|glutamatergic synapse|postsynaptic density, intracellular component|postsynapse to nucleus signaling pathway|protein tyrosine kinase binding|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway" PRRC1 1671.9266 1501.317233 1842.535968 1.22727957 0.295463927 0.213767404 1 26.84172241 32.3910528 133619 proline rich coiled-coil 1 "GO:0005515,GO:0005737,GO:0005794,GO:0034199,GO:0034237,GO:0042802" protein binding|cytoplasm|Golgi apparatus|activation of protein kinase A activity|protein kinase A regulatory subunit binding|identical protein binding PRRC2A 6041.614641 6290.342334 5792.886947 0.920917597 -0.118856024 0.623937694 1 48.56828837 43.97893909 7916 proline rich coiled-coil 2A "GO:0003723,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0016020,GO:0030154,GO:0070062" RNA binding|protein binding|nucleoplasm|cytosol|plasma membrane|membrane|cell differentiation|extracellular exosome PRRC2B 6426.023647 6919.792733 5932.25456 0.857287897 -0.222148319 0.360892459 1 32.61473286 27.4923394 84726 proline rich coiled-coil 2B "GO:0003723,GO:0005515,GO:0030154" RNA binding|protein binding|cell differentiation PRRC2C 5642.941281 6573.334911 4712.547652 0.716918842 -0.480118285 0.047001255 1 32.75201222 23.08761973 23215 proline rich coiled-coil 2C "GO:0002244,GO:0003723,GO:0005829,GO:0008022,GO:0010494,GO:0016020,GO:0030154,GO:0034063" hematopoietic progenitor cell differentiation|RNA binding|cytosol|protein C-terminus binding|cytoplasmic stress granule|membrane|cell differentiation|stress granule assembly PRRG1 947.0111043 814.6440701 1079.378139 1.324969 0.405958605 0.100412974 1 7.3377311 9.559577276 5638 proline rich and Gla domain 1 "GO:0005509,GO:0005515,GO:0005576,GO:0005887" calcium ion binding|protein binding|extracellular region|integral component of plasma membrane PRRG2 4.92466667 3.121241648 6.728091692 2.155581801 1.108077311 0.568402303 1 0.100165322 0.212301507 5639 proline rich and Gla domain 2 "GO:0005509,GO:0005515,GO:0005615,GO:0005886,GO:0005887" calcium ion binding|protein binding|extracellular space|plasma membrane|integral component of plasma membrane PRRG4 128.5464491 119.6475965 137.4453017 1.148751047 0.200066176 0.65230818 1 1.117496031 1.262243341 79056 proline rich and Gla domain 4 "GO:0003674,GO:0005509,GO:0005515,GO:0005576,GO:0005886,GO:0008150,GO:0016021,GO:0033116,GO:0050699" molecular_function|calcium ion binding|protein binding|extracellular region|plasma membrane|biological_process|integral component of membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|WW domain binding PRRT1 11.33069624 7.282897178 15.3784953 2.111590335 1.078329968 0.33937474 1 0.183337187 0.380654886 80863 proline rich transmembrane protein 1 "GO:0006468,GO:0007611,GO:0016020,GO:0030545,GO:0030672,GO:0034394,GO:0050808,GO:0060291,GO:0060292,GO:0098839,GO:0098978,GO:0099055,GO:2000311" protein phosphorylation|learning or memory|membrane|receptor regulator activity|synaptic vesicle membrane|protein localization to cell surface|synapse organization|long-term synaptic potentiation|long-term synaptic depression|postsynaptic density membrane|glutamatergic synapse|integral component of postsynaptic membrane|regulation of AMPA receptor activity PRRT2 127.6148613 145.6579436 109.571779 0.752254057 -0.410708113 0.342226931 1 2.888701873 2.13667486 112476 proline rich transmembrane protein 2 "GO:0005515,GO:0005886,GO:0008021,GO:0016020,GO:0016021,GO:0017075,GO:0030672,GO:0031629,GO:0031982,GO:0035544,GO:0042734,GO:0043197,GO:0043679,GO:0050884,GO:0098793,GO:0098839,GO:1905513" protein binding|plasma membrane|synaptic vesicle|membrane|integral component of membrane|syntaxin-1 binding|synaptic vesicle membrane|synaptic vesicle fusion to presynaptic active zone membrane|vesicle|negative regulation of SNARE complex assembly|presynaptic membrane|dendritic spine|axon terminus|neuromuscular process controlling posture|presynapse|postsynaptic density membrane|negative regulation of short-term synaptic potentiation PRRT3 49.71718384 56.18234966 43.25201802 0.769850643 -0.377349516 0.544600252 1 0.701040155 0.530665129 285368 proline rich transmembrane protein 3 GO:0016021 integral component of membrane PRRX1 4.444088692 3.121241648 5.766935736 1.847641543 0.88568489 0.705170935 1 0.038469961 0.069889292 5396 paired related homeobox 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001102,GO:0001227,GO:0001228,GO:0002053,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0030326,GO:0042472,GO:0042474,GO:0045880,GO:0045944,GO:0048664,GO:0048701,GO:0048844,GO:0051216,GO:0060021,GO:0070570,GO:0071837,GO:0097150,GO:0100026" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II activating transcription factor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|positive regulation of mesenchymal cell proliferation|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|embryonic limb morphogenesis|inner ear morphogenesis|middle ear morphogenesis|positive regulation of smoothened signaling pathway|positive regulation of transcription by RNA polymerase II|neuron fate determination|embryonic cranial skeleton morphogenesis|artery morphogenesis|cartilage development|roof of mouth development|regulation of neuron projection regeneration|HMG box domain binding|neuronal stem cell population maintenance|positive regulation of DNA repair by transcription from RNA polymerase II promoter" PRSS12 885.8927984 925.9683556 845.8172413 0.913440763 -0.130616922 0.601859661 1 8.615277071 7.737859079 8492 serine protease 12 "GO:0004252,GO:0005044,GO:0005886,GO:0006887,GO:0006897,GO:0008236,GO:0030424,GO:0030425,GO:0031410,GO:0031638,GO:0043083,GO:0043195" serine-type endopeptidase activity|scavenger receptor activity|plasma membrane|exocytosis|endocytosis|serine-type peptidase activity|axon|dendrite|cytoplasmic vesicle|zymogen activation|synaptic cleft|terminal bouton PRSS16 32.70887063 26.01034707 39.4073942 1.515066066 0.599380705 0.405461788 1 0.509590462 0.759143784 10279 serine protease 16 "GO:0005764,GO:0005768,GO:0006508,GO:0008236,GO:0008239,GO:0030163" lysosome|endosome|proteolysis|serine-type peptidase activity|dipeptidyl-peptidase activity|protein catabolic process PRSS23 2222.10114 2811.198311 1633.003969 0.580892484 -0.783656932 0.000963915 0.194410378 39.09027803 22.32727364 11098 serine protease 23 "GO:0004252,GO:0005515,GO:0005634,GO:0005788,GO:0006508,GO:0043687,GO:0044267,GO:0070062" serine-type endopeptidase activity|protein binding|nucleus|endoplasmic reticulum lumen|proteolysis|post-translational protein modification|cellular protein metabolic process|extracellular exosome PRSS27 4.602604545 7.282897178 1.922311912 0.263948792 -1.921670032 0.302322524 1 0.259983169 0.067473943 83886 serine protease 27 "GO:0004252,GO:0005576,GO:0006508" serine-type endopeptidase activity|extracellular region|proteolysis PRSS3 973.7045902 960.3020137 987.1071668 1.027913253 0.039718519 0.87600802 1 40.00745785 40.43603842 5646 serine protease 3 "GO:0004252,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0006508,GO:0007586,GO:0009235,GO:0019730,GO:0031638,GO:0043312,GO:0043542,GO:1904724" serine-type endopeptidase activity|calcium ion binding|protein binding|extracellular region|extracellular space|proteolysis|digestion|cobalamin metabolic process|antimicrobial humoral response|zymogen activation|neutrophil degranulation|endothelial cell migration|tertiary granule lumen "hsa04080,hsa04972,hsa04974,hsa05164" Neuroactive ligand-receptor interaction|Pancreatic secretion|Protein digestion and absorption|Influenza A PRSS35 26.78341904 21.84869154 31.71814655 1.451718356 0.537761587 0.497917583 1 0.457443904 0.652967237 167681 serine protease 35 "GO:0005515,GO:0005576" protein binding|extracellular region PRSS36 6.564545421 8.323311061 4.80577978 0.577387982 -0.792387015 0.636893371 1 0.15707207 0.089173926 146547 serine protease 36 "GO:0004252,GO:0005576,GO:0005737,GO:0006508" serine-type endopeptidase activity|extracellular region|cytoplasm|proteolysis PRSS53 154.6857439 149.8195991 159.5518887 1.064960056 0.09079932 0.835745738 1 2.407587066 2.521079257 339105 serine protease 53 "GO:0004252,GO:0005515,GO:0005576,GO:0006508" serine-type endopeptidase activity|protein binding|extracellular region|proteolysis PRSS8 2.883467868 0 5.766935736 Inf Inf 0.126446699 1 0 0.164736328 5652 serine protease 8 "GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0006508,GO:0008236,GO:0010765,GO:0016021,GO:0017080,GO:0070062,GO:0070268" serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|plasma membrane|proteolysis|serine-type peptidase activity|positive regulation of sodium ion transport|integral component of membrane|sodium channel regulator activity|extracellular exosome|cornification PRTFDC1 89.03525927 79.07145508 98.99906347 1.252020256 0.324257904 0.515682065 1 2.176327092 2.679209672 56952 phosphoribosyl transferase domain containing 1 "GO:0000166,GO:0000287,GO:0004422,GO:0005515,GO:0006166,GO:0006178,GO:0042803,GO:0046038" nucleotide binding|magnesium ion binding|hypoxanthine phosphoribosyltransferase activity|protein binding|purine ribonucleoside salvage|guanine salvage|protein homodimerization activity|GMP catabolic process PRTG 346.8414788 337.094098 356.5888597 1.05783181 0.081110264 0.795947078 1 1.233719137 1.283228813 283659 protogenin "GO:0005615,GO:0005886,GO:0016021,GO:0038023,GO:0042802,GO:0050768" extracellular space|plasma membrane|integral component of membrane|signaling receptor activity|identical protein binding|negative regulation of neurogenesis PRTN3 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.051892502 0.141411511 5657 proteinase 3 "GO:0004252,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005829,GO:0005886,GO:0006508,GO:0006509,GO:0006909,GO:0007596,GO:0008236,GO:0008284,GO:0019221,GO:0019730,GO:0019899,GO:0030574,GO:0035578,GO:0043231,GO:0043312,GO:0043547,GO:0044853,GO:0045217,GO:0050765,GO:0062023,GO:0070062,GO:0072672,GO:0097029" serine-type endopeptidase activity|signaling receptor binding|protein binding|extracellular region|extracellular space|cytosol|plasma membrane|proteolysis|membrane protein ectodomain proteolysis|phagocytosis|blood coagulation|serine-type peptidase activity|positive regulation of cell population proliferation|cytokine-mediated signaling pathway|antimicrobial humoral response|enzyme binding|collagen catabolic process|azurophil granule lumen|intracellular membrane-bounded organelle|neutrophil degranulation|positive regulation of GTPase activity|plasma membrane raft|cell-cell junction maintenance|negative regulation of phagocytosis|collagen-containing extracellular matrix|extracellular exosome|neutrophil extravasation|mature conventional dendritic cell differentiation PRUNE1 436.3371944 466.1054194 406.5689694 0.872268273 -0.197156179 0.488334422 1 8.105307778 6.951695897 58497 prune exopolyphosphatase 1 "GO:0004309,GO:0004427,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005925,GO:0006798,GO:0015631,GO:0016311,GO:0016791,GO:0031113,GO:0046872,GO:0050767" exopolyphosphatase activity|inorganic diphosphatase activity|protein binding|nucleus|cytoplasm|cytosol|focal adhesion|polyphosphate catabolic process|tubulin binding|dephosphorylation|phosphatase activity|regulation of microtubule polymerization|metal ion binding|regulation of neurogenesis hsa00230 Purine metabolism PRUNE2 83.31801334 55.14193578 111.4940909 2.021947349 1.015745431 0.042631793 1 0.19461833 0.386923193 158471 prune homolog 2 with BCH domain "GO:0004309,GO:0005737,GO:0006798,GO:0006915,GO:0046872" exopolyphosphatase activity|cytoplasm|polyphosphate catabolic process|apoptotic process|metal ion binding PRX 282.1672414 228.8910542 335.4434286 1.465515679 0.551408403 0.08686287 1 1.987875489 2.86451319 57716 periaxin "GO:0003674,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0008366,GO:0030054,GO:0032287,GO:0043484" molecular_function|protein binding|nucleus|cytoplasm|plasma membrane|axon ensheathment|cell junction|peripheral nervous system myelin maintenance|regulation of RNA splicing PRXL2A 387.7447128 401.5997587 373.8896669 0.931000726 -0.103145802 0.730267333 1 2.793982664 2.557672331 84293 peroxiredoxin like 2A "GO:0005576,GO:0005737,GO:0016209,GO:0045670,GO:0055114,GO:0098869" extracellular region|cytoplasm|antioxidant activity|regulation of osteoclast differentiation|oxidation-reduction process|cellular oxidant detoxification PRXL2B 718.5440648 696.0368875 741.0512421 1.064672369 0.090409539 0.727242592 1 13.16307917 13.77985524 127281 peroxiredoxin like 2B "GO:0001516,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0016209,GO:0016616,GO:0043209,GO:0047017,GO:0055114,GO:0070062,GO:0098869" "prostaglandin biosynthetic process|protein binding|cytoplasm|endoplasmic reticulum|cytosol|antioxidant activity|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|myelin sheath|prostaglandin-F synthase activity|oxidation-reduction process|extracellular exosome|cellular oxidant detoxification" hsa00590 Arachidonic acid metabolism PRXL2C 504.3414935 459.8629361 548.8200509 1.193442671 0.255129266 0.351035118 1 8.425005049 9.88650773 195827 peroxiredoxin like 2C "GO:0016209,GO:0045821,GO:0055114,GO:0070374,GO:0098869" antioxidant activity|positive regulation of glycolytic process|oxidation-reduction process|positive regulation of ERK1 and ERK2 cascade|cellular oxidant detoxification PSAP 23438.36453 24113.67256 22763.05651 0.943989616 -0.083157105 0.766583526 1 466.7763458 433.2586434 5660 prosaposin "GO:0002020,GO:0002576,GO:0004565,GO:0005515,GO:0005543,GO:0005576,GO:0005615,GO:0005764,GO:0005765,GO:0005770,GO:0005886,GO:0006687,GO:0006869,GO:0007041,GO:0007186,GO:0007193,GO:0008047,GO:0008289,GO:0010506,GO:0019216,GO:0035577,GO:0042803,GO:0043202,GO:0043231,GO:0043312,GO:0050790,GO:0060736,GO:0060742,GO:0062023,GO:0070062,GO:1905572,GO:1905573,GO:1905574,GO:1905575,GO:1905576,GO:1905577" protease binding|platelet degranulation|beta-galactosidase activity|protein binding|phospholipid binding|extracellular region|extracellular space|lysosome|lysosomal membrane|late endosome|plasma membrane|glycosphingolipid metabolic process|lipid transport|lysosomal transport|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|enzyme activator activity|lipid binding|regulation of autophagy|regulation of lipid metabolic process|azurophil granule membrane|protein homodimerization activity|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|regulation of catalytic activity|prostate gland growth|epithelial cell differentiation involved in prostate gland development|collagen-containing extracellular matrix|extracellular exosome|ganglioside GM1 transport to membrane|ganglioside GM1 binding|ganglioside GM2 binding|ganglioside GM3 binding|ganglioside GT1b binding|ganglioside GP1c binding "hsa00600,hsa04142" Sphingolipid metabolism|Lysosome PSAT1 3616.429849 4670.417919 2562.441779 0.548653637 -0.866032426 0.000289944 0.0777447 112.9880419 60.95395971 29968 phosphoserine aminotransferase 1 "GO:0004648,GO:0005515,GO:0005737,GO:0005829,GO:0006564,GO:0008615,GO:0030170,GO:0042802,GO:0070062" O-phospho-L-serine:2-oxoglutarate aminotransferase activity|protein binding|cytoplasm|cytosol|L-serine biosynthetic process|pyridoxine biosynthetic process|pyridoxal phosphate binding|identical protein binding|extracellular exosome "hsa00260,hsa00270,hsa00750" "Glycine, serine and threonine metabolism|Cysteine and methionine metabolism|Vitamin B6 metabolism" PSCA 42.6374619 34.33365813 50.94126567 1.483712149 0.569211225 0.379558398 1 1.865910623 2.722147592 8000 prostate stem cell antigen "GO:0005576,GO:0005886,GO:0031225,GO:0033130,GO:0070062,GO:0070373,GO:0099601" extracellular region|plasma membrane|anchored component of membrane|acetylcholine receptor binding|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|regulation of neurotransmitter receptor activity PSD 20.81833849 16.64662212 24.99005486 1.501208754 0.586124608 0.507804311 1 0.216577189 0.319687002 5662 pleckstrin and Sec7 domain containing "GO:0005085,GO:0005515,GO:0005543,GO:0007165,GO:0031175,GO:0032012,GO:0032154,GO:0032587,GO:0043197,GO:0050790,GO:0098999,GO:0099092" "guanyl-nucleotide exchange factor activity|protein binding|phospholipid binding|signal transduction|neuron projection development|regulation of ARF protein signal transduction|cleavage furrow|ruffle membrane|dendritic spine|regulation of catalytic activity|extrinsic component of postsynaptic endosome membrane|postsynaptic density, intracellular component" hsa04144 Endocytosis PSD3 571.1707862 586.7934298 555.5481426 0.946752493 -0.07894078 0.771586053 1 1.466452206 1.365134836 23362 pleckstrin and Sec7 domain containing 3 "GO:0014069,GO:0032012,GO:0032587,GO:0050790" postsynaptic density|regulation of ARF protein signal transduction|ruffle membrane|regulation of catalytic activity hsa04144 Endocytosis PSD4 173.0464723 202.8807071 143.2122374 0.70589382 -0.502476903 0.191169953 1 2.036368339 1.413405883 23550 pleckstrin and Sec7 domain containing 4 "GO:0005085,GO:0005543,GO:0016020,GO:0032012,GO:0032154,GO:0032587,GO:0050790" guanyl-nucleotide exchange factor activity|phospholipid binding|membrane|regulation of ARF protein signal transduction|cleavage furrow|ruffle membrane|regulation of catalytic activity hsa04144 Endocytosis PSEN1 1485.90771 1588.711999 1383.103421 0.870581592 -0.19994858 0.402837295 1 26.20916212 22.4353989 5663 presenilin 1 "GO:0000045,GO:0000122,GO:0000139,GO:0000186,GO:0000776,GO:0001568,GO:0001708,GO:0001756,GO:0001764,GO:0001921,GO:0001947,GO:0002038,GO:0002244,GO:0002265,GO:0002286,GO:0003407,GO:0004175,GO:0004190,GO:0005262,GO:0005515,GO:0005634,GO:0005640,GO:0005654,GO:0005739,GO:0005743,GO:0005765,GO:0005783,GO:0005789,GO:0005790,GO:0005791,GO:0005794,GO:0005813,GO:0005886,GO:0005887,GO:0005938,GO:0006486,GO:0006509,GO:0006816,GO:0006839,GO:0006974,GO:0006979,GO:0007175,GO:0007220,GO:0007611,GO:0007613,GO:0008013,GO:0008021,GO:0009791,GO:0009986,GO:0010468,GO:0010628,GO:0010629,GO:0010975,GO:0015031,GO:0015871,GO:0016020,GO:0016021,GO:0016080,GO:0016235,GO:0016324,GO:0016485,GO:0021549,GO:0021795,GO:0021870,GO:0021904,GO:0030018,GO:0030054,GO:0030165,GO:0030326,GO:0030426,GO:0031293,GO:0031594,GO:0031901,GO:0031965,GO:0032092,GO:0032436,GO:0032469,GO:0032760,GO:0032991,GO:0034205,GO:0035253,GO:0035333,GO:0035556,GO:0035577,GO:0042307,GO:0042325,GO:0042327,GO:0042383,GO:0042500,GO:0042982,GO:0042987,GO:0043005,GO:0043011,GO:0043025,GO:0043065,GO:0043066,GO:0043085,GO:0043198,GO:0043312,GO:0043406,GO:0043524,GO:0043589,GO:0045121,GO:0045296,GO:0045821,GO:0045893,GO:0048013,GO:0048143,GO:0048167,GO:0048471,GO:0048538,GO:0048666,GO:0048705,GO:0048854,GO:0050435,GO:0050673,GO:0050771,GO:0050808,GO:0050820,GO:0050852,GO:0051117,GO:0051208,GO:0051402,GO:0051444,GO:0051563,GO:0051966,GO:0060075,GO:0060828,GO:0060999,GO:0070588,GO:0070765,GO:0070851,GO:0090647,GO:0098609,GO:0098712,GO:0099056,GO:1904646,GO:1904797,GO:1905598,GO:1905908,GO:1990535,GO:2000059,GO:2001234" "autophagosome assembly|negative regulation of transcription by RNA polymerase II|Golgi membrane|activation of MAPKK activity|kinetochore|blood vessel development|cell fate specification|somitogenesis|neuron migration|positive regulation of receptor recycling|heart looping|positive regulation of L-glutamate import across plasma membrane|hematopoietic progenitor cell differentiation|astrocyte activation involved in immune response|T cell activation involved in immune response|neural retina development|endopeptidase activity|aspartic-type endopeptidase activity|calcium channel activity|protein binding|nucleus|nuclear outer membrane|nucleoplasm|mitochondrion|mitochondrial inner membrane|lysosomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|smooth endoplasmic reticulum|rough endoplasmic reticulum|Golgi apparatus|centrosome|plasma membrane|integral component of plasma membrane|cell cortex|protein glycosylation|membrane protein ectodomain proteolysis|calcium ion transport|mitochondrial transport|cellular response to DNA damage stimulus|response to oxidative stress|negative regulation of epidermal growth factor-activated receptor activity|Notch receptor processing|learning or memory|memory|beta-catenin binding|synaptic vesicle|post-embryonic development|cell surface|regulation of gene expression|positive regulation of gene expression|negative regulation of gene expression|regulation of neuron projection development|protein transport|choline transport|membrane|integral component of membrane|synaptic vesicle targeting|aggresome|apical plasma membrane|protein processing|cerebellum development|cerebral cortex cell migration|Cajal-Retzius cell differentiation|dorsal/ventral neural tube patterning|Z disc|cell junction|PDZ domain binding|embryonic limb morphogenesis|growth cone|membrane protein intracellular domain proteolysis|neuromuscular junction|early endosome membrane|nuclear membrane|positive regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|endoplasmic reticulum calcium ion homeostasis|positive regulation of tumor necrosis factor production|protein-containing complex|amyloid-beta formation|ciliary rootlet|Notch receptor processing, ligand-dependent|intracellular signal transduction|azurophil granule membrane|positive regulation of protein import into nucleus|regulation of phosphorylation|positive regulation of phosphorylation|sarcolemma|aspartic endopeptidase activity, intramembrane cleaving|amyloid precursor protein metabolic process|amyloid precursor protein catabolic process|neuron projection|myeloid dendritic cell differentiation|neuronal cell body|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of catalytic activity|dendritic shaft|neutrophil degranulation|positive regulation of MAP kinase activity|negative regulation of neuron apoptotic process|skin morphogenesis|membrane raft|cadherin binding|positive regulation of glycolytic process|positive regulation of transcription, DNA-templated|ephrin receptor signaling pathway|astrocyte activation|regulation of synaptic plasticity|perinuclear region of cytoplasm|thymus development|neuron development|skeletal system morphogenesis|brain morphogenesis|amyloid-beta metabolic process|epithelial cell proliferation|negative regulation of axonogenesis|synapse organization|positive regulation of coagulation|T cell receptor signaling pathway|ATPase binding|sequestering of calcium ion|neuron apoptotic process|negative regulation of ubiquitin-protein transferase activity|smooth endoplasmic reticulum calcium ion homeostasis|regulation of synaptic transmission, glutamatergic|regulation of resting membrane potential|regulation of canonical Wnt signaling pathway|positive regulation of dendritic spine development|calcium ion transmembrane transport|gamma-secretase complex|growth factor receptor binding|modulation of age-related behavioral decline|cell-cell adhesion|L-glutamate import across plasma membrane|integral component of presynaptic membrane|cellular response to amyloid-beta|negative regulation of core promoter binding|negative regulation of low-density lipoprotein receptor activity|positive regulation of amyloid fibril formation|neuron projection maintenance|negative regulation of ubiquitin-dependent protein catabolic process|negative regulation of apoptotic signaling pathway" "hsa04310,hsa04330,hsa04722,hsa05010,hsa05022,hsa05165" Wnt signaling pathway|Notch signaling pathway|Neurotrophin signaling pathway|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection PSEN2 202.763049 200.7998793 204.7262186 1.019553494 0.027937473 0.953334797 1 4.039321714 4.049390318 5664 presenilin 2 "GO:0000139,GO:0000776,GO:0004175,GO:0005515,GO:0005634,GO:0005637,GO:0005743,GO:0005765,GO:0005783,GO:0005789,GO:0005794,GO:0005813,GO:0005886,GO:0005887,GO:0005938,GO:0006509,GO:0006816,GO:0007220,GO:0009986,GO:0016020,GO:0016324,GO:0016485,GO:0030018,GO:0030426,GO:0031293,GO:0031594,GO:0032991,GO:0034205,GO:0035253,GO:0035333,GO:0035556,GO:0042500,GO:0042987,GO:0043025,GO:0043065,GO:0043066,GO:0043085,GO:0043198,GO:0045121,GO:0048013,GO:0048471,GO:0050435,GO:0070765,GO:0110097,GO:1990456" "Golgi membrane|kinetochore|endopeptidase activity|protein binding|nucleus|nuclear inner membrane|mitochondrial inner membrane|lysosomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|centrosome|plasma membrane|integral component of plasma membrane|cell cortex|membrane protein ectodomain proteolysis|calcium ion transport|Notch receptor processing|cell surface|membrane|apical plasma membrane|protein processing|Z disc|growth cone|membrane protein intracellular domain proteolysis|neuromuscular junction|protein-containing complex|amyloid-beta formation|ciliary rootlet|Notch receptor processing, ligand-dependent|intracellular signal transduction|aspartic endopeptidase activity, intramembrane cleaving|amyloid precursor protein catabolic process|neuronal cell body|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of catalytic activity|dendritic shaft|membrane raft|ephrin receptor signaling pathway|perinuclear region of cytoplasm|amyloid-beta metabolic process|gamma-secretase complex|regulation of calcium import into the mitochondrion|mitochondrion-endoplasmic reticulum membrane tethering" "hsa04330,hsa04722,hsa05010,hsa05022" Notch signaling pathway|Neurotrophin signaling pathway|Alzheimer disease|Pathways of neurodegeneration - multiple diseases PSENEN 451.3791507 406.8018281 495.9564733 1.219159893 0.285887348 0.308700583 1 19.31518318 23.15424781 55851 "presenilin enhancer, gamma-secretase subunit" "GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005887,GO:0006509,GO:0007220,GO:0010008,GO:0010950,GO:0016021,GO:0016485,GO:0019899,GO:0031293,GO:0032580,GO:0034205,GO:0035333,GO:0042982,GO:0042987,GO:0043065,GO:0043085,GO:0044267,GO:0048013,GO:0061133,GO:0070765" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|membrane protein ectodomain proteolysis|Notch receptor processing|endosome membrane|positive regulation of endopeptidase activity|integral component of membrane|protein processing|enzyme binding|membrane protein intracellular domain proteolysis|Golgi cisterna membrane|amyloid-beta formation|Notch receptor processing, ligand-dependent|amyloid precursor protein metabolic process|amyloid precursor protein catabolic process|positive regulation of apoptotic process|positive regulation of catalytic activity|cellular protein metabolic process|ephrin receptor signaling pathway|endopeptidase activator activity|gamma-secretase complex" "hsa04330,hsa05010" Notch signaling pathway|Alzheimer disease PSG1 184.74389 194.5573961 174.930384 0.899119682 -0.15341493 0.692138711 1 3.509013398 3.102227972 5669 pregnancy specific beta-1-glycoprotein 1 "GO:0005515,GO:0005576,GO:0007565,GO:0050900" protein binding|extracellular region|female pregnancy|leukocyte migration PSG11 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.108730372 0.164610876 5680 pregnancy specific beta-1-glycoprotein 11 "GO:0005576,GO:0007565" extracellular region|female pregnancy PSG2 12.29185219 7.282897178 17.30080721 2.375539127 1.248254969 0.245646158 1 0.247091441 0.577153148 5670 pregnancy specific beta-1-glycoprotein 2 "GO:0003674,GO:0005575,GO:0005576,GO:0007565,GO:0016477" molecular_function|cellular_component|extracellular region|female pregnancy|cell migration PSG3 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.059289884 0.080785006 5671 pregnancy specific beta-1-glycoprotein 3 "GO:0005576,GO:0006952,GO:0007565" extracellular region|defense response|female pregnancy PSG4 1421.883241 1358.780531 1484.985952 1.092881388 0.128136831 0.593785401 1 24.74935822 26.59549942 5672 pregnancy specific beta-1-glycoprotein 4 "GO:0005576,GO:0007565" extracellular region|female pregnancy PSG5 7.367185523 4.161655531 10.57271552 2.540507122 1.345116509 0.341208165 1 0.093673516 0.233995992 5673 pregnancy specific beta-1-glycoprotein 5 "GO:0005515,GO:0005576,GO:0007565" protein binding|extracellular region|female pregnancy PSG6 143.6871706 113.4051132 173.969228 1.534051006 0.617346452 0.134617989 1 3.345617724 5.046465339 5675 pregnancy specific beta-1-glycoprotein 6 "GO:0003674,GO:0005576,GO:0007565" molecular_function|extracellular region|female pregnancy PSG7 29.90466069 28.09117483 31.71814655 1.129114277 0.175191507 0.852735899 1 0.725289972 0.805231489 5676 pregnancy specific beta-1-glycoprotein 7 "GO:0005576,GO:0007565" extracellular region|female pregnancy PSG9 94.36627641 67.62690237 121.1056505 1.790791034 0.840597001 0.078963417 1 0.894011267 1.574197007 5678 pregnancy specific beta-1-glycoprotein 9 "GO:0005576,GO:0007565" extracellular region|female pregnancy PSIP1 2606.8132 2489.710421 2723.915979 1.094069397 0.129704251 0.583958841 1 25.14596315 27.05106224 11168 PC4 and SFRS1 interacting protein 1 "GO:0000395,GO:0003690,GO:0003712,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006979,GO:0009408,GO:0035327,GO:0051169,GO:0075713,GO:0097100" mRNA 5'-splice site recognition|double-stranded DNA binding|transcription coregulator activity|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|response to oxidative stress|response to heat|transcriptionally active chromatin|nuclear transport|establishment of integrated proviral latency|supercoiled DNA binding PSKH1 610.721605 628.4099851 593.0332248 0.943704331 -0.08359317 0.754668312 1 9.590244763 8.898910079 5681 protein serine kinase H1 "GO:0005515,GO:0005524,GO:0005789,GO:0005794,GO:0005815,GO:0005829,GO:0005886,GO:0006468,GO:0007368,GO:0007507,GO:0016607,GO:0106310,GO:0106311" protein binding|ATP binding|endoplasmic reticulum membrane|Golgi apparatus|microtubule organizing center|cytosol|plasma membrane|protein phosphorylation|determination of left/right symmetry|heart development|nuclear speck|protein serine kinase activity|protein threonine kinase activity PSMA1 3924.560704 3675.782247 4173.339161 1.135360824 0.183150867 0.441785669 1 94.22177845 105.1856223 5682 proteasome 20S subunit alpha 1 "GO:0000165,GO:0000209,GO:0000502,GO:0001530,GO:0002223,GO:0002479,GO:0002862,GO:0003723,GO:0004175,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005839,GO:0005844,GO:0006521,GO:0010499,GO:0010972,GO:0016579,GO:0019773,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|lipopolysaccharide binding|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|negative regulation of inflammatory response to antigenic stimulus|RNA binding|endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|proteasome core complex|polysome|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|proteasome core complex, alpha-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMA2 1970.572501 1683.389662 2257.755341 1.341195916 0.423519996 0.073678153 1 62.64952045 82.61923171 5683 proteasome 20S subunit alpha 2 "GO:0000165,GO:0000209,GO:0000502,GO:0000932,GO:0002223,GO:0002479,GO:0004175,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0009615,GO:0010499,GO:0010972,GO:0016579,GO:0019773,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|P-body|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|response to virus|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|proteasome core complex, alpha-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMA3 1491.373319 1442.013641 1540.732997 1.068459377 0.095532058 0.690833083 1 80.58389291 84.65983884 5684 proteasome 20S subunit alpha 3 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019773,GO:0031145,GO:0031146,GO:0031625,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0045202,GO:0050852,GO:0052548,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, alpha-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|ubiquitin protein ligase binding|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|synapse|T cell receptor signaling pathway|regulation of endopeptidase activity|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMA4 1996.378444 1944.533547 2048.223342 1.053323737 0.074948914 0.752997311 1 23.23173975 24.06106154 5685 proteasome 20S subunit alpha 4 "GO:0000165,GO:0000209,GO:0000502,GO:0000932,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019773,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043231,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|P-body|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, alpha-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMA5 2292.442818 2172.384187 2412.50145 1.110531675 0.151250542 0.522868505 1 30.38955475 33.18382664 5686 proteasome 20S subunit alpha 5 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016579,GO:0019773,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|proteasome core complex, alpha-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMA6 2902.6398 2711.318578 3093.961022 1.141127807 0.190460383 0.4211593 1 51.64100261 57.94288731 5687 proteasome 20S subunit alpha 6 "GO:0000165,GO:0000209,GO:0000502,GO:0000932,GO:0002223,GO:0002479,GO:0003723,GO:0004175,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0005844,GO:0006521,GO:0010499,GO:0010972,GO:0016363,GO:0016579,GO:0019773,GO:0030016,GO:0030017,GO:0031145,GO:0031146,GO:0033209,GO:0035639,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050727,GO:0050852,GO:0051059,GO:0051092,GO:0051603,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|P-body|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|RNA binding|endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|polysome|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|nuclear matrix|protein deubiquitination|proteasome core complex, alpha-subunit complex|myofibril|sarcomere|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|purine ribonucleoside triphosphate binding|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|regulation of inflammatory response|T cell receptor signaling pathway|NF-kappaB binding|positive regulation of NF-kappaB transcription factor activity|proteolysis involved in cellular protein catabolic process|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMA7 4036.761857 3908.834957 4164.688757 1.065455258 0.091470011 0.701575917 1 216.8475442 227.1751919 5688 proteasome 20S subunit alpha 7 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019773,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0042802,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:0098794,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, alpha-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|postsynapse|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMB1 2074.015039 1787.43105 2360.599028 1.320665783 0.401265414 0.089910678 1 107.0616274 139.0266138 5689 proteasome 20S subunit beta 1 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMB10 180.8596372 193.5169822 168.2022923 0.86918621 -0.202262809 0.600250067 1 10.57077346 9.034222276 5699 proteasome 20S subunit beta 10 "GO:0000165,GO:0000209,GO:0000502,GO:0000902,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0006959,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0042098,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1990111" "MAPK cascade|protein polyubiquitination|proteasome complex|cell morphogenesis|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|humoral immune response|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|T cell proliferation|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|spermatoproteasome complex" hsa03050 Proteasome PSMB2 2343.864048 2273.304334 2414.423761 1.062076787 0.086888075 0.714349237 1 26.79374429 27.98082424 5690 proteasome 20S subunit beta 2 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010243,GO:0010499,GO:0010972,GO:0014070,GO:0016020,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|response to organonitrogen compound|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|response to organic cyclic compound|membrane|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMB3 2139.244082 1910.199889 2368.288276 1.239811755 0.310121087 0.189748293 1 133.7845896 163.0921353 5691 proteasome 20S subunit beta 3 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMB4 3860.65831 3739.247494 3982.069126 1.064938636 0.090770302 0.703437491 1 217.3820984 227.6247798 5692 proteasome 20S subunit beta 4 "GO:0000165,GO:0000209,GO:0000502,GO:0001530,GO:0002223,GO:0002479,GO:0002862,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0036064,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|lipopolysaccharide binding|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|negative regulation of inflammatory response to antigenic stimulus|endopeptidase activity|threonine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|ciliary basal body|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMB5 2286.765816 2048.574935 2524.956696 1.232543 0.301637979 0.202000264 1 87.95549409 106.594852 5693 proteasome 20S subunit beta 5 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005839,GO:0006508,GO:0006521,GO:0006979,GO:0008233,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|proteasome core complex|proteolysis|regulation of cellular amino acid metabolic process|response to oxidative stress|peptidase activity|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMB6 1478.581996 1282.830317 1674.333675 1.305187173 0.384256714 0.107682861 1 81.1164648 104.100542 5694 proteasome 20S subunit beta 6 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0045296,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|cadherin binding|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMB7 2809.58128 2678.025334 2941.137225 1.09824847 0.135204489 0.568207081 1 145.2452135 156.8460604 5695 proteasome 20S subunit beta 7 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0016604,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|nuclear body|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSMB8 635.1518239 626.3291574 643.9744905 1.02817262 0.040082499 0.883603896 1 21.91871212 22.15910655 5696 proteasome 20S subunit beta 8 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0045444,GO:0050852,GO:0052548,GO:0055085,GO:0060071,GO:0060337,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1990111" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|fat cell differentiation|T cell receptor signaling pathway|regulation of endopeptidase activity|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|type I interferon signaling pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|spermatoproteasome complex" hsa03050 Proteasome PSMB9 310.7289334 310.043337 311.4145297 1.004422584 0.006366373 0.995576497 1 16.26985552 16.06835226 5698 proteasome 20S subunit beta 9 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010499,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1990111,GO:2000116" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|spermatoproteasome complex|regulation of cysteine-type endopeptidase activity" hsa03050 Proteasome PSMC1 2535.252355 2377.345722 2693.158989 1.132842802 0.179947681 0.446899747 1 21.31987427 23.74791399 5700 "proteasome 26S subunit, ATPase 1" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006457,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016579,GO:0016887,GO:0017025,GO:0022624,GO:0031145,GO:0031146,GO:0033209,GO:0036402,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901215,GO:1901800,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|protein folding|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|ATPase activity|TBP-class protein binding|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|proteasome-activating ATPase activity|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|negative regulation of neuron death|positive regulation of proteasomal protein catabolic process|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05165,hsa05169,hsa05203" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Epstein-Barr virus infection|Viral carcinogenesis PSMC2 1962.237901 1893.553266 2030.922535 1.072545764 0.101039207 0.670734635 1 35.69602883 37.64496644 5701 "proteasome 26S subunit, ATPase 2" "GO:0000165,GO:0000209,GO:0000502,GO:0000932,GO:0001649,GO:0002223,GO:0002479,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016579,GO:0016887,GO:0017025,GO:0022624,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0036402,GO:0036464,GO:0038061,GO:0038095,GO:0043161,GO:0043197,GO:0043312,GO:0043488,GO:0043687,GO:0045899,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901800,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|P-body|osteoblast differentiation|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|ATPase activity|TBP-class protein binding|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|proteasome-activating ATPase activity|cytoplasmic ribonucleoprotein granule|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|dendritic spine|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|positive regulation of RNA polymerase II transcription preinitiation complex assembly|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|positive regulation of proteasomal protein catabolic process|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMC3 3257.954274 2892.350594 3623.557954 1.252807306 0.325164531 0.170216641 1 100.2333995 123.4718388 5702 "proteasome 26S subunit, ATPase 3" "GO:0000165,GO:0000209,GO:0000502,GO:0000932,GO:0002223,GO:0002479,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016032,GO:0016579,GO:0016887,GO:0022624,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0036402,GO:0038061,GO:0038095,GO:0042802,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0043921,GO:0045899,GO:0045944,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901800,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|P-body|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytosol|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|viral process|protein deubiquitination|ATPase activity|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|proteasome-activating ATPase activity|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|modulation by host of viral transcription|positive regulation of RNA polymerase II transcription preinitiation complex assembly|positive regulation of transcription by RNA polymerase II|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|positive regulation of proteasomal protein catabolic process|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMC3IP 698.8453981 683.5519209 714.1388753 1.044747083 0.06315373 0.810256398 1 22.82847916 23.45088978 29893 PSMC3 interacting protein "GO:0003677,GO:0005654,GO:0007131,GO:0030374,GO:0045893" "DNA binding|nucleoplasm|reciprocal meiotic recombination|nuclear receptor coactivator activity|positive regulation of transcription, DNA-templated" PSMC4 1360.11701 1289.072801 1431.161218 1.110225286 0.150852457 0.530751505 1 39.22203315 42.81662146 5704 "proteasome 26S subunit, ATPase 4" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006508,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016234,GO:0016579,GO:0016887,GO:0022624,GO:0031145,GO:0031146,GO:0031597,GO:0033209,GO:0036402,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0045202,GO:0045899,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901800,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|proteolysis|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|inclusion body|protein deubiquitination|ATPase activity|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cytosolic proteasome complex|tumor necrosis factor-mediated signaling pathway|proteasome-activating ATPase activity|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|synapse|positive regulation of RNA polymerase II transcription preinitiation complex assembly|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|positive regulation of proteasomal protein catabolic process|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMC5 3317.400675 3153.494478 3481.306873 1.103952107 0.142677584 0.547752832 1 107.126801 116.2838889 5705 "proteasome 26S subunit, ATPase 5" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006521,GO:0008134,GO:0008540,GO:0010972,GO:0016020,GO:0016234,GO:0016579,GO:0016887,GO:0017025,GO:0022624,GO:0031145,GO:0031146,GO:0031410,GO:0031531,GO:0031595,GO:0031597,GO:0033209,GO:0038061,GO:0038095,GO:0043069,GO:0043161,GO:0043488,GO:0043687,GO:0045892,GO:0045893,GO:0045899,GO:0050804,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0072562,GO:0090090,GO:0090261,GO:0090263,GO:0098794,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|regulation of cellular amino acid metabolic process|transcription factor binding|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|inclusion body|protein deubiquitination|ATPase activity|TBP-class protein binding|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cytoplasmic vesicle|thyrotropin-releasing hormone receptor binding|nuclear proteasome complex|cytosolic proteasome complex|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|negative regulation of programmed cell death|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of RNA polymerase II transcription preinitiation complex assembly|modulation of chemical synaptic transmission|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|blood microparticle|negative regulation of canonical Wnt signaling pathway|positive regulation of inclusion body assembly|positive regulation of canonical Wnt signaling pathway|postsynapse|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMC6 1506.480057 1321.325631 1691.634483 1.280255558 0.356431822 0.135272275 1 19.11540266 24.06308467 5706 "proteasome 26S subunit, ATPase 6" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016579,GO:0016887,GO:0022624,GO:0030433,GO:0030674,GO:0031145,GO:0031146,GO:0031597,GO:0033209,GO:0038061,GO:0038095,GO:0042802,GO:0043161,GO:0043488,GO:0043687,GO:0045899,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|ATPase activity|proteasome accessory complex|ubiquitin-dependent ERAD pathway|protein-macromolecule adaptor activity|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cytosolic proteasome complex|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|positive regulation of RNA polymerase II transcription preinitiation complex assembly|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD1 3815.118487 3553.013409 4077.223565 1.147539594 0.198543932 0.403982459 1 43.79163868 49.41172941 5707 "proteasome 26S subunit, non-ATPase 1" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0005838,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016579,GO:0022624,GO:0030234,GO:0031145,GO:0031146,GO:0031625,GO:0033209,GO:0034515,GO:0035578,GO:0038061,GO:0038095,GO:0042176,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050790,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytosol|proteasome regulatory particle|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|proteasome accessory complex|enzyme regulator activity|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|ubiquitin protein ligase binding|tumor necrosis factor-mediated signaling pathway|proteasome storage granule|azurophil granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|regulation of protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|regulation of catalytic activity|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD10 1920.820719 1613.681932 2227.959506 1.38066831 0.46536677 0.049527489 1 58.58451625 79.53227098 5716 "proteasome 26S subunit, non-ATPase 10" "GO:0000122,GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006521,GO:0006915,GO:0007253,GO:0008134,GO:0008540,GO:0010972,GO:0016579,GO:0030307,GO:0031145,GO:0031146,GO:0031398,GO:0032088,GO:0032436,GO:0033209,GO:0038061,GO:0038095,GO:0043066,GO:0043161,GO:0043409,GO:0043488,GO:0043518,GO:0043687,GO:0045111,GO:0045737,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0070682,GO:0090090,GO:0090201,GO:0090263,GO:1901990,GO:1902036" "negative regulation of transcription by RNA polymerase II|MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|apoptotic process|cytoplasmic sequestering of NF-kappaB|transcription factor binding|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|positive regulation of cell growth|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|negative regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of MAPK cascade|regulation of mRNA stability|negative regulation of DNA damage response, signal transduction by p53 class mediator|post-translational protein modification|intermediate filament cytoskeleton|positive regulation of cyclin-dependent protein serine/threonine kinase activity|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|proteasome regulatory particle assembly|negative regulation of canonical Wnt signaling pathway|negative regulation of release of cytochrome c from mitochondria|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" PSMD11 2220.667508 2294.112611 2147.222406 0.935970795 -0.09546458 0.687472823 1 31.80066848 29.26642843 5717 "proteasome 26S subunit, non-ATPase 11" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005198,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0006521,GO:0008541,GO:0010972,GO:0016020,GO:0016579,GO:0022624,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043248,GO:0043312,GO:0043488,GO:0043687,GO:0048863,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|structural molecule activity|protein binding|extracellular region|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|proteasome regulatory particle, lid subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|proteasome assembly|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|stem cell differentiation|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD12 2396.648982 2170.303359 2622.994604 1.208584317 0.273318127 0.247639996 1 23.5656361 28.00446628 5718 "proteasome 26S subunit, non-ATPase 12" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005576,GO:0005654,GO:0005737,GO:0005829,GO:0005838,GO:0006521,GO:0008541,GO:0010972,GO:0016020,GO:0016579,GO:0022624,GO:0031145,GO:0031146,GO:0031595,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|extracellular region|nucleoplasm|cytoplasm|cytosol|proteasome regulatory particle|regulation of cellular amino acid metabolic process|proteasome regulatory particle, lid subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|nuclear proteasome complex|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD13 2141.928791 2005.917966 2277.939616 1.135609559 0.183466898 0.438237779 1 63.79747027 71.23668087 5719 "proteasome 26S subunit, non-ATPase 13" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005198,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0005838,GO:0006511,GO:0006521,GO:0007127,GO:0008541,GO:0010972,GO:0016020,GO:0016579,GO:0022624,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043248,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|structural molecule activity|extracellular region|nucleus|nucleoplasm|cytosol|proteasome regulatory particle|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|meiosis I|proteasome regulatory particle, lid subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|proteasome assembly|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD14 2624.075607 2286.829714 2961.3215 1.294946223 0.372892186 0.114901417 1 77.88378993 99.1676424 10213 "proteasome 26S subunit, non-ATPase 14" "GO:0000165,GO:0000209,GO:0000502,GO:0000724,GO:0002223,GO:0002479,GO:0004843,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0006303,GO:0006511,GO:0006521,GO:0008237,GO:0008541,GO:0010950,GO:0010972,GO:0016579,GO:0018215,GO:0022624,GO:0031145,GO:0031146,GO:0031597,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0045471,GO:0046872,GO:0050852,GO:0055085,GO:0060071,GO:0061133,GO:0061136,GO:0061418,GO:0061578,GO:0070122,GO:0070498,GO:0070536,GO:0070628,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|double-strand break repair via homologous recombination|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|thiol-dependent ubiquitin-specific protease activity|protein binding|extracellular region|nucleus|nucleoplasm|cytosol|double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|metallopeptidase activity|proteasome regulatory particle, lid subcomplex|positive regulation of endopeptidase activity|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|protein phosphopantetheinylation|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cytosolic proteasome complex|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|response to ethanol|metal ion binding|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|endopeptidase activator activity|regulation of proteasomal protein catabolic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|Lys63-specific deubiquitinase activity|isopeptidase activity|interleukin-1-mediated signaling pathway|protein K63-linked deubiquitination|proteasome binding|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD2 12040.98788 10967.00274 13114.97302 1.19585755 0.258045546 0.313496097 1 193.9326639 228.0350427 5708 "proteasome 26S subunit, non-ATPase 2" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0005838,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016579,GO:0022624,GO:0030234,GO:0031145,GO:0031146,GO:0033209,GO:0034515,GO:0034774,GO:0038061,GO:0038095,GO:0042176,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050790,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytosol|proteasome regulatory particle|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|proteasome accessory complex|enzyme regulator activity|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|proteasome storage granule|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|regulation of protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|regulation of catalytic activity|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD3 2887.15125 2885.067697 2889.234804 1.001444371 0.002082283 0.994659745 1 71.71437375 70.61617965 5709 "proteasome 26S subunit, non-ATPase 3" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0006521,GO:0008541,GO:0010972,GO:0016020,GO:0016579,GO:0022624,GO:0030234,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0042176,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050790,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|extracellular region|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|proteasome regulatory particle, lid subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|proteasome accessory complex|enzyme regulator activity|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|regulation of protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|regulation of catalytic activity|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD4 2872.615024 2881.946455 2863.283593 0.993524216 -0.009372963 0.970016201 1 117.4974679 114.7831512 5710 "proteasome 26S subunit, non-ATPase 4" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006521,GO:0008540,GO:0010972,GO:0016579,GO:0022624,GO:0031145,GO:0031146,GO:0031593,GO:0033209,GO:0038061,GO:0038095,GO:0042802,GO:0043161,GO:0043248,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|polyubiquitin modification-dependent protein binding|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|proteasome assembly|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD5 1548.501119 1692.753387 1404.248852 0.829564934 -0.269573183 0.258026931 1 26.71965014 21.79477209 5711 "proteasome 26S subunit, non-ATPase 5" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005654,GO:0005829,GO:0006521,GO:0008540,GO:0010972,GO:0016579,GO:0022624,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0070682,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|nucleoplasm|cytosol|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|proteasome regulatory particle assembly|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" PSMD6 1435.279674 1407.679983 1462.879365 1.039213019 0.05549141 0.819065146 1 44.85092149 45.82971196 9861 "proteasome 26S subunit, non-ATPase 6" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005576,GO:0005654,GO:0005829,GO:0005838,GO:0006508,GO:0006521,GO:0010972,GO:0016579,GO:0016887,GO:0022624,GO:0030234,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050790,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|extracellular region|nucleoplasm|cytosol|proteasome regulatory particle|proteolysis|regulation of cellular amino acid metabolic process|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|ATPase activity|proteasome accessory complex|enzyme regulator activity|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|regulation of catalytic activity|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD7 2514.379297 2397.113586 2631.645008 1.097839094 0.13466662 0.569564191 1 78.43626386 84.66945599 5713 "proteasome 26S subunit, non-ATPase 7" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0005838,GO:0006521,GO:0008237,GO:0010972,GO:0016020,GO:0016579,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0042803,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070122,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1904813" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|extracellular region|nucleus|nucleoplasm|cytosol|proteasome regulatory particle|regulation of cellular amino acid metabolic process|metallopeptidase activity|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|protein homodimerization activity|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|isopeptidase activity|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD8 2965.070278 2722.763131 3207.377425 1.177986211 0.236322652 0.318200315 1 95.72388937 110.8745121 5714 "proteasome 26S subunit, non-ATPase 8" "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005838,GO:0006521,GO:0008541,GO:0010972,GO:0016579,GO:0022624,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|nucleus|nucleoplasm|cytosol|proteasome regulatory particle|regulation of cellular amino acid metabolic process|proteasome regulatory particle, lid subcomplex|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection PSMD9 951.9653391 843.7756588 1060.155019 1.256441814 0.329343861 0.182442401 1 16.52504812 20.41532474 5715 "proteasome 26S subunit, non-ATPase 9" "GO:0000165,GO:0000209,GO:0002223,GO:0002479,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005838,GO:0006511,GO:0006521,GO:0008540,GO:0010972,GO:0016579,GO:0031145,GO:0031146,GO:0032024,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043425,GO:0043488,GO:0043687,GO:0045893,GO:0046676,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0070682,GO:0090090,GO:0090263,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome regulatory particle|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|positive regulation of insulin secretion|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|bHLH transcription factor binding|regulation of mRNA stability|post-translational protein modification|positive regulation of transcription, DNA-templated|negative regulation of insulin secretion|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|proteasome regulatory particle assembly|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" "hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022" Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases PSME1 2208.078746 2228.566537 2187.590956 0.981613481 -0.026773032 0.911750807 1 123.2481867 118.9576103 5720 proteasome activator subunit 1 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006521,GO:0008537,GO:0010950,GO:0010972,GO:0016579,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061133,GO:0061136,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:2000045" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|nucleoplasm|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|proteasome activator complex|positive regulation of endopeptidase activity|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|endopeptidase activator activity|regulation of proteasomal protein catabolic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|regulation of G1/S transition of mitotic cell cycle" "hsa03050,hsa04612" Proteasome|Antigen processing and presentation PSME2 1809.315953 1739.572012 1879.059894 1.080185173 0.11127865 0.640056956 1 117.0715776 124.3428625 5721 proteasome activator subunit 2 "GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006521,GO:0008537,GO:0010950,GO:0010972,GO:0016020,GO:0016579,GO:0031145,GO:0031146,GO:0033209,GO:0035722,GO:0038061,GO:0038095,GO:0042802,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061133,GO:0061136,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:2000045" "MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|nucleoplasm|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|proteasome activator complex|positive regulation of endopeptidase activity|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|interleukin-12-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|endopeptidase activator activity|regulation of proteasomal protein catabolic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|regulation of G1/S transition of mitotic cell cycle" "hsa03050,hsa04612" Proteasome|Antigen processing and presentation PSME3 4395.468102 4418.63776 4372.298444 0.98951276 -0.015209784 0.950226502 1 66.46408572 64.66653818 10197 proteasome activator subunit 3 "GO:0000165,GO:0000209,GO:0000502,GO:0002039,GO:0002223,GO:0002479,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006521,GO:0006915,GO:0007049,GO:0008537,GO:0010950,GO:0010972,GO:0016020,GO:0016032,GO:0016579,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0042802,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061133,GO:0061136,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:0097371,GO:1901990,GO:1902036,GO:2000045,GO:2001237" "MAPK cascade|protein polyubiquitination|proteasome complex|p53 binding|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|apoptotic process|cell cycle|proteasome activator complex|positive regulation of endopeptidase activity|negative regulation of G2/M transition of mitotic cell cycle|membrane|viral process|protein deubiquitination|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|endopeptidase activator activity|regulation of proteasomal protein catabolic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|MDM2/MDM4 family protein binding|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|regulation of G1/S transition of mitotic cell cycle|negative regulation of extrinsic apoptotic signaling pathway" "hsa03050,hsa04612,hsa05160" Proteasome|Antigen processing and presentation|Hepatitis C PSME3IP1 2084.897913 2110.999768 2058.796058 0.975270623 -0.036125495 0.880522699 1 17.26328191 16.55463782 80011 proteasome activator subunit 3 interacting protein 1 "GO:0005515,GO:0005634,GO:0032091,GO:1901799" protein binding|nucleus|negative regulation of protein binding|negative regulation of proteasomal protein catabolic process PSME4 2018.707714 1988.23093 2049.184498 1.030657188 0.04356455 0.855825044 1 14.74954552 14.94734483 23198 proteasome activator subunit 4 "GO:0000165,GO:0000209,GO:0002223,GO:0002479,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006521,GO:0006974,GO:0007275,GO:0010499,GO:0010952,GO:0010972,GO:0016504,GO:0016579,GO:0016607,GO:0031145,GO:0031146,GO:0033209,GO:0035093,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0070577,GO:0070628,GO:0090090,GO:0090263,GO:1901990,GO:1902036,GO:1990111" "MAPK cascade|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|nucleus|nucleoplasm|cytosol|DNA repair|regulation of cellular amino acid metabolic process|cellular response to DNA damage stimulus|multicellular organism development|proteasomal ubiquitin-independent protein catabolic process|positive regulation of peptidase activity|negative regulation of G2/M transition of mitotic cell cycle|peptidase activator activity|protein deubiquitination|nuclear speck|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|spermatogenesis, exchange of chromosomal proteins|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|lysine-acetylated histone binding|proteasome binding|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation|spermatoproteasome complex" hsa03050 Proteasome PSMF1 1993.435226 1993.432999 1993.437453 1.000002234 3.22E-06 1 1 12.81602884 12.60159811 9491 proteasome inhibitor subunit 1 "GO:0000165,GO:0000209,GO:0002223,GO:0002479,GO:0004866,GO:0005515,GO:0005654,GO:0005783,GO:0005829,GO:0005839,GO:0006511,GO:0006521,GO:0010951,GO:0010972,GO:0016020,GO:0016579,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0042803,GO:0043161,GO:0043488,GO:0043687,GO:0046982,GO:0048471,GO:0050852,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0070628,GO:0090090,GO:0090263,GO:1901799,GO:1901990,GO:1902036" "MAPK cascade|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase inhibitor activity|protein binding|nucleoplasm|endoplasmic reticulum|cytosol|proteasome core complex|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|negative regulation of endopeptidase activity|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|protein homodimerization activity|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|protein heterodimerization activity|perinuclear region of cytoplasm|T cell receptor signaling pathway|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|proteasome binding|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|negative regulation of proteasomal protein catabolic process|regulation of mitotic cell cycle phase transition|regulation of hematopoietic stem cell differentiation" hsa03050 Proteasome PSMG1 779.1113669 759.5021343 798.7205994 1.05163707 0.072636903 0.777755595 1 19.98680128 20.66713897 8624 proteasome assembly chaperone 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005794,GO:0005829,GO:0021930,GO:0051131,GO:0060090,GO:0070628,GO:0080129,GO:0101031" protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|Golgi apparatus|cytosol|cerebellar granule cell precursor proliferation|chaperone-mediated protein complex assembly|molecular adaptor activity|proteasome binding|proteasome core complex assembly|chaperone complex PSMG2 1059.69848 934.2916666 1185.105294 1.268453242 0.34307034 0.160780609 1 45.08266645 56.22833664 56984 proteasome assembly chaperone 2 "GO:0005515,GO:0005634,GO:0005829,GO:0007094,GO:0043066,GO:0043248,GO:0051131,GO:0060090,GO:0101031" protein binding|nucleus|cytosol|mitotic spindle assembly checkpoint|negative regulation of apoptotic process|proteasome assembly|chaperone-mediated protein complex assembly|molecular adaptor activity|chaperone complex PSMG3 505.6045899 505.641147 505.5680329 0.999855403 -0.000208624 1 1 18.67483646 18.35968323 84262 proteasome assembly chaperone 3 "GO:0005515,GO:0032991,GO:0044877,GO:0051131,GO:0060090" protein binding|protein-containing complex|protein-containing complex binding|chaperone-mediated protein complex assembly|molecular adaptor activity PSMG4 305.7746986 280.9117483 330.6376489 1.177016094 0.235134048 0.455805383 1 2.079587143 2.406748466 389362 proteasome assembly chaperone 4 "GO:0032991,GO:0043248,GO:0044877" protein-containing complex|proteasome assembly|protein-containing complex binding PSORS1C1 67.77597177 63.46524684 72.0866967 1.135845211 0.183766243 0.753923975 1 3.607053866 4.028496195 170679 psoriasis susceptibility 1 candidate 1 PSPC1 719.5888947 786.5528953 652.6248941 0.829727915 -0.26928977 0.291752199 1 5.29877334 4.322970012 55269 paraspeckle component 1 "GO:0000398,GO:0000976,GO:0001650,GO:0002218,GO:0003676,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0016363,GO:0016607,GO:0042752,GO:0045087,GO:0045892,GO:0048511" "mRNA splicing, via spliceosome|transcription regulatory region sequence-specific DNA binding|fibrillar center|activation of innate immune response|nucleic acid binding|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|nuclear matrix|nuclear speck|regulation of circadian rhythm|innate immune response|negative regulation of transcription, DNA-templated|rhythmic process" PSPH 542.0486439 604.4804658 479.616822 0.793436429 -0.333813458 0.213769687 1 10.26408256 8.00761992 5723 phosphoserine phosphatase "GO:0000287,GO:0001701,GO:0004647,GO:0005509,GO:0005737,GO:0005829,GO:0006563,GO:0006564,GO:0009612,GO:0016311,GO:0031667,GO:0033574,GO:0042802,GO:0042803,GO:0043005" magnesium ion binding|in utero embryonic development|phosphoserine phosphatase activity|calcium ion binding|cytoplasm|cytosol|L-serine metabolic process|L-serine biosynthetic process|response to mechanical stimulus|dephosphorylation|response to nutrient levels|response to testosterone|identical protein binding|protein homodimerization activity|neuron projection hsa00260 "Glycine, serine and threonine metabolism" PSPN 2.080827765 4.161655531 0 0 #NAME? 0.234194363 1 0.316832963 0 5623 persephin "GO:0000165,GO:0005102,GO:0005576,GO:0005615,GO:0007399,GO:0007411,GO:0007417,GO:0008083,GO:0030116,GO:0030971" MAPK cascade|signaling receptor binding|extracellular region|extracellular space|nervous system development|axon guidance|central nervous system development|growth factor activity|glial cell-derived neurotrophic factor receptor binding|receptor tyrosine kinase binding PSRC1 726.2823878 773.0275148 679.5372609 0.879059604 -0.185967106 0.467262829 1 23.20306957 20.05556696 84722 proline and serine rich coiled-coil 1 "GO:0000922,GO:0001578,GO:0005515,GO:0005654,GO:0005737,GO:0005819,GO:0005829,GO:0005876,GO:0007080,GO:0008017,GO:0015630,GO:0030308,GO:0030496,GO:0031116,GO:0045737,GO:0045893,GO:0051301,GO:0060236" "spindle pole|microtubule bundle formation|protein binding|nucleoplasm|cytoplasm|spindle|cytosol|spindle microtubule|mitotic metaphase plate congression|microtubule binding|microtubule cytoskeleton|negative regulation of cell growth|midbody|positive regulation of microtubule polymerization|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription, DNA-templated|cell division|regulation of mitotic spindle organization" PSTK 24.2220133 17.687036 30.75699059 1.738956747 0.798222049 0.321533847 1 0.702324854 1.200875532 118672 phosphoseryl-tRNA kinase "GO:0000049,GO:0005524,GO:0006412,GO:0016301,GO:0016310,GO:0043915,GO:0097056" tRNA binding|ATP binding|translation|kinase activity|phosphorylation|L-seryl-tRNA(Sec) kinase activity|selenocysteinyl-tRNA(Sec) biosynthetic process "hsa00450,hsa00970" Selenocompound metabolism|Aminoacyl-tRNA biosynthesis PSTPIP2 756.5940134 685.6327487 827.5552781 1.206994969 0.271419662 0.284737045 1 11.78073395 13.98134611 9050 proline-serine-threonine phosphatase interacting protein 2 "GO:0005737,GO:0005829,GO:0005856,GO:0005884,GO:0005886,GO:0016477,GO:0030041,GO:0051015" cytoplasm|cytosol|cytoskeleton|actin filament|plasma membrane|cell migration|actin filament polymerization|actin filament binding PTAFR 7.045123399 8.323311061 5.766935736 0.692865579 -0.529352609 0.780164403 1 0.105787048 0.072069691 5724 platelet activating factor receptor "GO:0001530,GO:0001875,GO:0002693,GO:0004930,GO:0004992,GO:0005515,GO:0005543,GO:0005886,GO:0005887,GO:0006357,GO:0006935,GO:0006954,GO:0006955,GO:0007186,GO:0007567,GO:0009609,GO:0010863,GO:0016020,GO:0016021,GO:0019221,GO:0030667,GO:0031663,GO:0032755,GO:0032760,GO:0032959,GO:0035589,GO:0043312,GO:0043315,GO:0045028,GO:0045056,GO:0045727,GO:0045776,GO:0045907,GO:0048015,GO:0048661,GO:0051019,GO:0060333,GO:0060732,GO:0070821,GO:0071258,GO:0071320,GO:0071398,GO:0071548,GO:1902943,GO:1903238,GO:1904058,GO:1904300,GO:1904303,GO:1904306,GO:1904317" lipopolysaccharide binding|lipopolysaccharide immune receptor activity|positive regulation of cellular extravasation|G protein-coupled receptor activity|platelet activating factor receptor activity|protein binding|phospholipid binding|plasma membrane|integral component of plasma membrane|regulation of transcription by RNA polymerase II|chemotaxis|inflammatory response|immune response|G protein-coupled receptor signaling pathway|parturition|response to symbiotic bacterium|positive regulation of phospholipase C activity|membrane|integral component of membrane|cytokine-mediated signaling pathway|secretory granule membrane|lipopolysaccharide-mediated signaling pathway|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|inositol trisphosphate biosynthetic process|G protein-coupled purinergic nucleotide receptor signaling pathway|neutrophil degranulation|positive regulation of neutrophil degranulation|G protein-coupled purinergic nucleotide receptor activity|transcytosis|positive regulation of translation|negative regulation of blood pressure|positive regulation of vasoconstriction|phosphatidylinositol-mediated signaling|positive regulation of smooth muscle cell proliferation|mitogen-activated protein kinase binding|interferon-gamma-mediated signaling pathway|positive regulation of inositol phosphate biosynthetic process|tertiary granule membrane|cellular response to gravity|cellular response to cAMP|cellular response to fatty acid|response to dexamethasone|positive regulation of voltage-gated chloride channel activity|positive regulation of leukocyte tethering or rolling|positive regulation of sensory perception of pain|positive regulation of transcytosis|positive regulation of maternal process involved in parturition|positive regulation of gastro-intestinal system smooth muscle contraction|cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine "hsa04020,hsa04080,hsa05150" Calcium signaling pathway|Neuroactive ligand-receptor interaction|Staphylococcus aureus infection PTAR1 2205.026087 2350.294961 2059.757214 0.876382432 -0.190367531 0.421001212 1 12.25509745 10.56043021 375743 protein prenyltransferase alpha subunit repeat containing 1 "GO:0005737,GO:0008318,GO:0018215,GO:0018342" cytoplasm|protein prenyltransferase activity|protein phosphopantetheinylation|protein prenylation PTBP1 5914.848308 5927.237889 5902.458726 0.995819442 -0.006043913 0.980845712 1 82.65633456 80.93342542 5725 polypyrimidine tract binding protein 1 "GO:0000381,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006397,GO:0006417,GO:0008187,GO:0008380,GO:0008543,GO:0016020,GO:0016070,GO:0033119,GO:0035307,GO:0036002,GO:0043484,GO:0045595,GO:0048025,GO:0051148,GO:0070062,GO:0070886,GO:0075522" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|nucleolus|mRNA processing|regulation of translation|poly-pyrimidine tract binding|RNA splicing|fibroblast growth factor receptor signaling pathway|membrane|RNA metabolic process|negative regulation of RNA splicing|positive regulation of protein dephosphorylation|pre-mRNA binding|regulation of RNA splicing|regulation of cell differentiation|negative regulation of mRNA splicing, via spliceosome|negative regulation of muscle cell differentiation|extracellular exosome|positive regulation of calcineurin-NFAT signaling cascade|IRES-dependent viral translational initiation" PTBP2 303.8077273 292.356301 315.2591536 1.078338837 0.108810574 0.736581194 1 4.622968432 4.901707062 58155 polypyrimidine tract binding protein 2 "GO:0003723,GO:0003729,GO:0005634,GO:0005681,GO:0006376,GO:0006417,GO:0021510,GO:0021549,GO:0030426,GO:0033119,GO:0043025,GO:0043484,GO:2000177" RNA binding|mRNA binding|nucleus|spliceosomal complex|mRNA splice site selection|regulation of translation|spinal cord development|cerebellum development|growth cone|negative regulation of RNA splicing|neuronal cell body|regulation of RNA splicing|regulation of neural precursor cell proliferation PTBP3 1921.973146 1934.129408 1909.816885 0.987429733 -0.018250008 0.94087879 1 12.66359118 12.29516215 9991 polypyrimidine tract binding protein 3 "GO:0003723,GO:0003729,GO:0005634,GO:0006397,GO:0006417,GO:0008380,GO:0009653,GO:0033119,GO:0043249,GO:0043484,GO:0045595,GO:0048025" "RNA binding|mRNA binding|nucleus|mRNA processing|regulation of translation|RNA splicing|anatomical structure morphogenesis|negative regulation of RNA splicing|erythrocyte maturation|regulation of RNA splicing|regulation of cell differentiation|negative regulation of mRNA splicing, via spliceosome" PTCD2 292.744373 317.3262342 268.1625117 0.845068837 -0.242859231 0.446947687 1 8.535845715 7.092671113 79810 pentatricopeptide repeat domain 2 "GO:0001822,GO:0001889,GO:0003723,GO:0005515,GO:0005739,GO:0006397,GO:0007005,GO:0007275,GO:0010468,GO:0048747,GO:0050684,GO:0055010" kidney development|liver development|RNA binding|protein binding|mitochondrion|mRNA processing|mitochondrion organization|multicellular organism development|regulation of gene expression|muscle fiber development|regulation of mRNA processing|ventricular cardiac muscle tissue morphogenesis PTCD3 1553.996912 1471.14523 1636.848593 1.112635625 0.153981205 0.519095764 1 11.75158166 12.85643217 55037 pentatricopeptide repeat domain 3 "GO:0003723,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0019843,GO:0032543,GO:0043024,GO:0070125,GO:0070126" RNA binding|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|cytosol|ribosome|plasma membrane|regulation of translation|rRNA binding|mitochondrial translation|ribosomal small subunit binding|mitochondrial translational elongation|mitochondrial translational termination PTCH1 415.7861978 481.7116277 349.860768 0.726286741 -0.461388853 0.10667305 1 2.608366905 1.862721707 5727 patched 1 "GO:0000122,GO:0001658,GO:0001701,GO:0001709,GO:0001843,GO:0003007,GO:0005113,GO:0005119,GO:0005515,GO:0005634,GO:0005794,GO:0005886,GO:0005901,GO:0007224,GO:0007346,GO:0007420,GO:0008158,GO:0008201,GO:0008589,GO:0009612,GO:0009887,GO:0009953,GO:0009957,GO:0010157,GO:0010875,GO:0014069,GO:0015485,GO:0016021,GO:0016485,GO:0021522,GO:0021532,GO:0021997,GO:0030326,GO:0030332,GO:0030496,GO:0030666,GO:0030850,GO:0032355,GO:0032526,GO:0032880,GO:0035108,GO:0035137,GO:0040015,GO:0042493,GO:0042593,GO:0043231,GO:0043433,GO:0043616,GO:0044294,GO:0044295,GO:0044877,GO:0045177,GO:0045606,GO:0045668,GO:0045879,GO:0045893,GO:0048471,GO:0048568,GO:0048745,GO:0050680,GO:0051782,GO:0060037,GO:0060170,GO:0060603,GO:0060644,GO:0060831,GO:0061005,GO:0061053,GO:0071397,GO:0071679,GO:0072203,GO:0072205,GO:0072659,GO:0097108,GO:0097421" "negative regulation of transcription by RNA polymerase II|branching involved in ureteric bud morphogenesis|in utero embryonic development|cell fate determination|neural tube closure|heart morphogenesis|patched binding|smoothened binding|protein binding|nucleus|Golgi apparatus|plasma membrane|caveola|smoothened signaling pathway|regulation of mitotic cell cycle|brain development|hedgehog receptor activity|heparin binding|regulation of smoothened signaling pathway|response to mechanical stimulus|animal organ morphogenesis|dorsal/ventral pattern formation|epidermal cell fate specification|response to chlorate|positive regulation of cholesterol efflux|postsynaptic density|cholesterol binding|integral component of membrane|protein processing|spinal cord motor neuron differentiation|neural tube patterning|neural plate axis specification|embryonic limb morphogenesis|cyclin binding|midbody|endocytic vesicle membrane|prostate gland development|response to estradiol|response to retinoic acid|regulation of protein localization|limb morphogenesis|hindlimb morphogenesis|negative regulation of multicellular organism growth|response to drug|glucose homeostasis|intracellular membrane-bounded organelle|negative regulation of DNA-binding transcription factor activity|keratinocyte proliferation|dendritic growth cone|axonal growth cone|protein-containing complex binding|apical part of cell|positive regulation of epidermal cell differentiation|negative regulation of osteoblast differentiation|negative regulation of smoothened signaling pathway|positive regulation of transcription, DNA-templated|perinuclear region of cytoplasm|embryonic organ development|smooth muscle tissue development|negative regulation of epithelial cell proliferation|negative regulation of cell division|pharyngeal system development|ciliary membrane|mammary gland duct morphogenesis|mammary gland epithelial cell differentiation|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|cell differentiation involved in kidney development|somite development|cellular response to cholesterol|commissural neuron axon guidance|cell proliferation involved in metanephros development|metanephric collecting duct development|protein localization to plasma membrane|hedgehog family protein binding|liver regeneration" "hsa04024,hsa04340,hsa04360,hsa05200,hsa05205,hsa05217" cAMP signaling pathway|Hedgehog signaling pathway|Axon guidance|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma PTCH2 11.00863411 11.44455271 10.57271552 0.923820772 -0.11431511 1 1 0.115896536 0.105275995 8643 patched 2 "GO:0001558,GO:0001709,GO:0005119,GO:0005886,GO:0007224,GO:0008158,GO:0009957,GO:0016021,GO:0042633,GO:0043588,GO:0045606,GO:0045879,GO:0097108" regulation of cell growth|cell fate determination|smoothened binding|plasma membrane|smoothened signaling pathway|hedgehog receptor activity|epidermal cell fate specification|integral component of membrane|hair cycle|skin development|positive regulation of epidermal cell differentiation|negative regulation of smoothened signaling pathway|hedgehog family protein binding "hsa04340,hsa05200,hsa05217" Hedgehog signaling pathway|Pathways in cancer|Basal cell carcinoma PTCHD4 28.86424681 26.01034707 31.71814655 1.219443419 0.28622282 0.733025322 1 0.049213799 0.0590092 442213 patched domain containing 4 "GO:0003674,GO:0005575,GO:0008150,GO:0016020,GO:0016021" molecular_function|cellular_component|biological_process|membrane|integral component of membrane PTDSS1 2413.942915 2485.548766 2342.337065 0.942382261 -0.085615713 0.718318648 1 26.58299988 24.63214714 9791 phosphatidylserine synthase 1 "GO:0005789,GO:0006659,GO:0016020,GO:0016021,GO:0016740,GO:0106245,GO:0106258" endoplasmic reticulum membrane|phosphatidylserine biosynthetic process|membrane|integral component of membrane|transferase activity|L-serine-phosphatidylethanolamine phosphatidyltransferase activity|L-serine-phosphatidylcholine phosphatidyltransferase activity hsa00564 Glycerophospholipid metabolism PTDSS2 947.957169 852.0989699 1043.815368 1.224993111 0.292773636 0.236252415 1 8.718358116 10.50121449 81490 phosphatidylserine synthase 2 "GO:0003882,GO:0005789,GO:0006659,GO:0016020,GO:0016021,GO:0016740,GO:0106245" CDP-diacylglycerol-serine O-phosphatidyltransferase activity|endoplasmic reticulum membrane|phosphatidylserine biosynthetic process|membrane|integral component of membrane|transferase activity|L-serine-phosphatidylethanolamine phosphatidyltransferase activity hsa00564 Glycerophospholipid metabolism PTEN 3348.97797 3503.073543 3194.882398 0.912022645 -0.132858449 0.575750179 1 21.55321612 19.32808754 5728 phosphatase and tensin homolog "GO:0001525,GO:0001933,GO:0002902,GO:0004438,GO:0004721,GO:0004722,GO:0004725,GO:0005161,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006367,GO:0006470,GO:0006661,GO:0006915,GO:0007270,GO:0007416,GO:0007417,GO:0007507,GO:0007568,GO:0007584,GO:0007611,GO:0007613,GO:0007626,GO:0008138,GO:0008284,GO:0008285,GO:0008289,GO:0009749,GO:0009898,GO:0010043,GO:0010628,GO:0010666,GO:0010719,GO:0010975,GO:0010977,GO:0010997,GO:0014065,GO:0014067,GO:0014823,GO:0016311,GO:0016314,GO:0016324,GO:0016477,GO:0016579,GO:0016605,GO:0019899,GO:0021542,GO:0021955,GO:0030165,GO:0030336,GO:0030534,GO:0031642,GO:0031647,GO:0032228,GO:0032286,GO:0032355,GO:0032535,GO:0032869,GO:0033032,GO:0033137,GO:0033198,GO:0033555,GO:0035176,GO:0035255,GO:0035335,GO:0035749,GO:0042493,GO:0042711,GO:0042802,GO:0042995,GO:0043005,GO:0043066,GO:0043197,GO:0043220,GO:0043491,GO:0043542,GO:0043647,GO:0044320,GO:0045211,GO:0045475,GO:0045666,GO:0045736,GO:0045792,GO:0046621,GO:0046685,GO:0046855,GO:0046856,GO:0048008,GO:0048681,GO:0048738,GO:0048853,GO:0048854,GO:0048870,GO:0050680,GO:0050765,GO:0050771,GO:0050821,GO:0051091,GO:0051548,GO:0051717,GO:0051800,GO:0051895,GO:0051896,GO:0051898,GO:0060024,GO:0060044,GO:0060070,GO:0060074,GO:0060134,GO:0060179,GO:0060291,GO:0060292,GO:0060736,GO:0060997,GO:0061002,GO:0070373,GO:0070374,GO:0071257,GO:0071361,GO:0071456,GO:0090071,GO:0090344,GO:0090394,GO:0097105,GO:0097107,GO:0099524,GO:0106306,GO:0106307,GO:1901017,GO:1902807,GO:1903690,GO:1903984,GO:1904668,GO:1904706,GO:1990090,GO:1990314,GO:1990381,GO:1990782,GO:2000060,GO:2000134,GO:2000272,GO:2000463,GO:2000808" "angiogenesis|negative regulation of protein phosphorylation|regulation of B cell apoptotic process|phosphatidylinositol-3-phosphatase activity|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|platelet-derived growth factor receptor binding|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|plasma membrane|transcription initiation from RNA polymerase II promoter|protein dephosphorylation|phosphatidylinositol biosynthetic process|apoptotic process|neuron-neuron synaptic transmission|synapse assembly|central nervous system development|heart development|aging|response to nutrient|learning or memory|memory|locomotory behavior|protein tyrosine/serine/threonine phosphatase activity|positive regulation of cell population proliferation|negative regulation of cell population proliferation|lipid binding|response to glucose|cytoplasmic side of plasma membrane|response to zinc ion|positive regulation of gene expression|positive regulation of cardiac muscle cell apoptotic process|negative regulation of epithelial to mesenchymal transition|regulation of neuron projection development|negative regulation of neuron projection development|anaphase-promoting complex binding|phosphatidylinositol 3-kinase signaling|negative regulation of phosphatidylinositol 3-kinase signaling|response to activity|dephosphorylation|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|apical plasma membrane|cell migration|protein deubiquitination|PML body|enzyme binding|dentate gyrus development|central nervous system neuron axonogenesis|PDZ domain binding|negative regulation of cell migration|adult behavior|negative regulation of myelination|regulation of protein stability|regulation of synaptic transmission, GABAergic|central nervous system myelin maintenance|response to estradiol|regulation of cellular component size|cellular response to insulin stimulus|regulation of myeloid cell apoptotic process|negative regulation of peptidyl-serine phosphorylation|response to ATP|multicellular organismal response to stress|social behavior|ionotropic glutamate receptor binding|peptidyl-tyrosine dephosphorylation|myelin sheath adaxonal region|response to drug|maternal behavior|identical protein binding|cell projection|neuron projection|negative regulation of apoptotic process|dendritic spine|Schmidt-Lanterman incisure|protein kinase B signaling|endothelial cell migration|inositol phosphate metabolic process|cellular response to leptin stimulus|postsynaptic membrane|locomotor rhythm|positive regulation of neuron differentiation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of cell size|negative regulation of organ growth|response to arsenic-containing substance|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|platelet-derived growth factor receptor signaling pathway|negative regulation of axon regeneration|cardiac muscle tissue development|forebrain morphogenesis|brain morphogenesis|cell motility|negative regulation of epithelial cell proliferation|negative regulation of phagocytosis|negative regulation of axonogenesis|protein stabilization|positive regulation of DNA-binding transcription factor activity|negative regulation of keratinocyte migration|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|negative regulation of focal adhesion assembly|regulation of protein kinase B signaling|negative regulation of protein kinase B signaling|rhythmic synaptic transmission|negative regulation of cardiac muscle cell proliferation|canonical Wnt signaling pathway|synapse maturation|prepulse inhibition|male mating behavior|long-term synaptic potentiation|long-term synaptic depression|prostate gland growth|dendritic spine morphogenesis|negative regulation of dendritic spine morphogenesis|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|cellular response to electrical stimulus|cellular response to ethanol|cellular response to hypoxia|negative regulation of ribosome biogenesis|negative regulation of cell aging|negative regulation of excitatory postsynaptic potential|presynaptic membrane assembly|postsynaptic density assembly|postsynaptic cytosol|protein serine phosphatase activity|protein threonine phosphatase activity|negative regulation of potassium ion transmembrane transporter activity|negative regulation of cell cycle G1/S phase transition|negative regulation of wound healing, spreading of epidermal cells|positive regulation of TRAIL-activated apoptotic signaling pathway|positive regulation of ubiquitin protein ligase activity|negative regulation of vascular associated smooth muscle cell proliferation|cellular response to nerve growth factor stimulus|cellular response to insulin-like growth factor stimulus|ubiquitin-specific protease binding|protein tyrosine kinase binding|positive regulation of ubiquitin-dependent protein catabolic process|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of signaling receptor activity|positive regulation of excitatory postsynaptic potential|negative regulation of synaptic vesicle clustering" "hsa00562,hsa01521,hsa04068,hsa04070,hsa04071,hsa04115,hsa04140,hsa04150,hsa04151,hsa04218,hsa04510,hsa04931,hsa05165,hsa05166,hsa05200,hsa05206,hsa05213,hsa05214,hsa05215,hsa05218,hsa05222,hsa05224,hsa05225,hsa05230,hsa05235" Inositol phosphate metabolism|EGFR tyrosine kinase inhibitor resistance|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|p53 signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Focal adhesion|Insulin resistance|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|MicroRNAs in cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Central carbon metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer PTER 275.6964308 286.1138177 265.2790439 0.92718012 -0.109078462 0.745303243 1 3.986780313 3.634608139 9317 phosphotriesterase related "GO:0003674,GO:0005515,GO:0008270,GO:0009056,GO:0016788,GO:0030855,GO:0070062" "molecular_function|protein binding|zinc ion binding|catabolic process|hydrolase activity, acting on ester bonds|epithelial cell differentiation|extracellular exosome" PTGER2 71.93259688 84.27352449 59.59166927 0.707122072 -0.499968802 0.345904378 1 1.829749029 1.272204999 5732 prostaglandin E receptor 2 "GO:0004957,GO:0005886,GO:0005887,GO:0006954,GO:0007186,GO:0007189,GO:0007204,GO:0071380,GO:1904346" prostaglandin E receptor activity|plasma membrane|integral component of plasma membrane|inflammatory response|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|cellular response to prostaglandin E stimulus|positive regulation of gastric mucosal blood circulation "hsa04024,hsa04080,hsa04750,hsa04924,hsa05163,hsa05200" cAMP signaling pathway|Neuroactive ligand-receptor interaction|Inflammatory mediator regulation of TRP channels|Renin secretion|Human cytomegalovirus infection|Pathways in cancer PTGER4 38.11411528 29.13158871 47.09664184 1.616686351 0.693039812 0.302192575 1 0.682784079 1.085376305 5734 prostaglandin E receptor 4 "GO:0001818,GO:0001819,GO:0004957,GO:0005515,GO:0005886,GO:0006954,GO:0006955,GO:0007186,GO:0007188,GO:0007189,GO:0007204,GO:0007254,GO:0009612,GO:0016021,GO:0030278,GO:0032496,GO:0033624,GO:0042093,GO:0050728,GO:0050729,GO:0051492,GO:0060348,GO:0070371,GO:0071260,GO:0071380,GO:2000420" negative regulation of cytokine production|positive regulation of cytokine production|prostaglandin E receptor activity|protein binding|plasma membrane|inflammatory response|immune response|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|JNK cascade|response to mechanical stimulus|integral component of membrane|regulation of ossification|response to lipopolysaccharide|negative regulation of integrin activation|T-helper cell differentiation|negative regulation of inflammatory response|positive regulation of inflammatory response|regulation of stress fiber assembly|bone development|ERK1 and ERK2 cascade|cellular response to mechanical stimulus|cellular response to prostaglandin E stimulus|negative regulation of eosinophil extravasation "hsa04080,hsa04750,hsa04924,hsa05163,hsa05165,hsa05200" Neuroactive ligand-receptor interaction|Inflammatory mediator regulation of TRP channels|Renin secretion|Human cytomegalovirus infection|Human papillomavirus infection|Pathways in cancer PTGES 1242.706914 1360.861358 1124.552469 0.826353443 -0.275169121 0.254569883 1 41.47725274 33.70132705 9536 prostaglandin E synthase "GO:0001516,GO:0002526,GO:0002544,GO:0004364,GO:0004602,GO:0004667,GO:0005515,GO:0005641,GO:0005789,GO:0006693,GO:0007165,GO:0008285,GO:0014070,GO:0016020,GO:0016021,GO:0019233,GO:0019371,GO:0031620,GO:0032308,GO:0032496,GO:0032526,GO:0034097,GO:0043295,GO:0048471,GO:0050220,GO:0050727,GO:0051592,GO:0055114,GO:0098869" prostaglandin biosynthetic process|acute inflammatory response|chronic inflammatory response|glutathione transferase activity|glutathione peroxidase activity|prostaglandin-D synthase activity|protein binding|nuclear envelope lumen|endoplasmic reticulum membrane|prostaglandin metabolic process|signal transduction|negative regulation of cell population proliferation|response to organic cyclic compound|membrane|integral component of membrane|sensory perception of pain|cyclooxygenase pathway|regulation of fever generation|positive regulation of prostaglandin secretion|response to lipopolysaccharide|response to retinoic acid|response to cytokine|glutathione binding|perinuclear region of cytoplasm|prostaglandin-E synthase activity|regulation of inflammatory response|response to calcium ion|oxidation-reduction process|cellular oxidant detoxification hsa00590 Arachidonic acid metabolism PTGES2 1018.605319 1142.374443 894.836195 0.783312512 -0.352340091 0.151013082 1 31.45842334 24.22942986 80142 prostaglandin E synthase 2 "GO:0000139,GO:0003677,GO:0005515,GO:0005576,GO:0005634,GO:0005739,GO:0005829,GO:0006629,GO:0006749,GO:0015035,GO:0016021,GO:0016829,GO:0019371,GO:0020037,GO:0035578,GO:0043295,GO:0043312,GO:0045893,GO:0048471,GO:0050220,GO:0055114" "Golgi membrane|DNA binding|protein binding|extracellular region|nucleus|mitochondrion|cytosol|lipid metabolic process|glutathione metabolic process|protein disulfide oxidoreductase activity|integral component of membrane|lyase activity|cyclooxygenase pathway|heme binding|azurophil granule lumen|glutathione binding|neutrophil degranulation|positive regulation of transcription, DNA-templated|perinuclear region of cytoplasm|prostaglandin-E synthase activity|oxidation-reduction process" hsa00590 Arachidonic acid metabolism PTGES3 8468.555625 7527.394441 9409.716809 1.250062938 0.322000733 0.193955503 1 115.8037494 142.3395795 10728 prostaglandin E synthase 3 "GO:0000723,GO:0000781,GO:0001516,GO:0003720,GO:0005515,GO:0005634,GO:0005654,GO:0005697,GO:0005829,GO:0006457,GO:0006805,GO:0007004,GO:0007165,GO:0019371,GO:0032991,GO:0042327,GO:0050220,GO:0050821,GO:0051082,GO:0051085,GO:0051087,GO:0051131,GO:0051879,GO:0051973,GO:0070182,GO:0101031,GO:1900034,GO:1905323" "telomere maintenance|chromosome, telomeric region|prostaglandin biosynthetic process|telomerase activity|protein binding|nucleus|nucleoplasm|telomerase holoenzyme complex|cytosol|protein folding|xenobiotic metabolic process|telomere maintenance via telomerase|signal transduction|cyclooxygenase pathway|protein-containing complex|positive regulation of phosphorylation|prostaglandin-E synthase activity|protein stabilization|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding|chaperone-mediated protein complex assembly|Hsp90 protein binding|positive regulation of telomerase activity|DNA polymerase binding|chaperone complex|regulation of cellular response to heat|telomerase holoenzyme complex assembly" hsa00590 Arachidonic acid metabolism PTGES3L 13.57003986 15.60620824 11.53387147 0.739056617 -0.436243205 0.713968318 1 0.539776183 0.392249688 100885848 prostaglandin E synthase 3 like "GO:0005634,GO:0005829,GO:0006457,GO:0051087,GO:0051131,GO:0051879" nucleus|cytosol|protein folding|chaperone binding|chaperone-mediated protein complex assembly|Hsp90 protein binding PTGES3L-AARSD1 4.444088692 3.121241648 5.766935736 1.847641543 0.88568489 0.705170935 1 0.072995149 0.132612022 100885850 PTGES3L-AARSD1 readthrough PTGFRN 80.74654676 75.95021343 85.54288008 1.126302037 0.171593762 0.753195988 1 0.63135877 0.699201361 5738 prostaglandin F2 receptor inhibitor "GO:0005515,GO:0005789,GO:0005794,GO:0009986,GO:0014905,GO:0016021,GO:0034389" protein binding|endoplasmic reticulum membrane|Golgi apparatus|cell surface|myoblast fusion involved in skeletal muscle regeneration|integral component of membrane|lipid droplet organization PTGIR 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.080161179 0.097087146 5739 prostaglandin I2 receptor "GO:0005085,GO:0005829,GO:0005886,GO:0005887,GO:0006954,GO:0007186,GO:0007187,GO:0007189,GO:0007204,GO:0007267,GO:0010642,GO:0016501,GO:0032496,GO:0048662,GO:0050790" "guanyl-nucleotide exchange factor activity|cytosol|plasma membrane|integral component of plasma membrane|inflammatory response|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|cell-cell signaling|negative regulation of platelet-derived growth factor receptor signaling pathway|prostacyclin receptor activity|response to lipopolysaccharide|negative regulation of smooth muscle cell proliferation|regulation of catalytic activity" "hsa04080,hsa04270,hsa04611" Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction|Platelet activation PTGR1 1913.818412 1896.674508 1930.962316 1.018077855 0.025847893 0.915323269 1 47.63389767 47.68351796 22949 prostaglandin reductase 1 "GO:0005515,GO:0005737,GO:0006691,GO:0006693,GO:0035798,GO:0036102,GO:0036132,GO:0036185,GO:0047522,GO:0055114,GO:0070062,GO:0097257,GO:0097327,GO:2001302" protein binding|cytoplasm|leukotriene metabolic process|prostaglandin metabolic process|2-alkenal reductase (NADP+) activity|leukotriene B4 metabolic process|13-prostaglandin reductase activity|13-lipoxin reductase activity|15-oxoprostaglandin 13-oxidase activity|oxidation-reduction process|extracellular exosome|leukotriene B4 12-hydroxy dehydrogenase activity|response to antineoplastic agent|lipoxin A4 metabolic process PTGR2 308.84122 323.5687175 294.1137225 0.908968348 -0.137698037 0.665512585 1 4.516941606 4.037052666 145482 prostaglandin reductase 2 "GO:0005515,GO:0005737,GO:0006693,GO:0008270,GO:0036132,GO:0047522,GO:0055114" protein binding|cytoplasm|prostaglandin metabolic process|zinc ion binding|13-prostaglandin reductase activity|15-oxoprostaglandin 13-oxidase activity|oxidation-reduction process PTGS1 8.085537281 10.40413883 5.766935736 0.554292463 -0.851280704 0.546153423 1 0.089082267 0.048551361 5742 prostaglandin-endoperoxide synthase 1 "GO:0001516,GO:0001750,GO:0004601,GO:0004666,GO:0005515,GO:0005737,GO:0005789,GO:0005794,GO:0006805,GO:0006954,GO:0006979,GO:0008217,GO:0019371,GO:0020037,GO:0042127,GO:0043231,GO:0046872,GO:0051213,GO:0055114,GO:0070062,GO:0098869" prostaglandin biosynthetic process|photoreceptor outer segment|peroxidase activity|prostaglandin-endoperoxide synthase activity|protein binding|cytoplasm|endoplasmic reticulum membrane|Golgi apparatus|xenobiotic metabolic process|inflammatory response|response to oxidative stress|regulation of blood pressure|cyclooxygenase pathway|heme binding|regulation of cell population proliferation|intracellular membrane-bounded organelle|metal ion binding|dioxygenase activity|oxidation-reduction process|extracellular exosome|cellular oxidant detoxification "hsa00590,hsa04611,hsa04726,hsa04923" Arachidonic acid metabolism|Platelet activation|Serotonergic synapse|Regulation of lipolysis in adipocytes PTGS2 712.9551522 751.1788233 674.7314811 0.898230169 -0.154842916 0.546940683 1 8.888920885 7.850690509 5743 prostaglandin-endoperoxide synthase 2 "GO:0001516,GO:0004601,GO:0004666,GO:0005515,GO:0005637,GO:0005640,GO:0005737,GO:0005783,GO:0005788,GO:0005789,GO:0006954,GO:0006979,GO:0008217,GO:0010575,GO:0019221,GO:0019371,GO:0019372,GO:0019899,GO:0020037,GO:0031394,GO:0031622,GO:0034356,GO:0042759,GO:0043005,GO:0045429,GO:0046872,GO:0050727,GO:0051213,GO:0055114,GO:0071456,GO:0071636,GO:0090050,GO:0090271,GO:0090336,GO:0090362,GO:0098869,GO:0150077" prostaglandin biosynthetic process|peroxidase activity|prostaglandin-endoperoxide synthase activity|protein binding|nuclear inner membrane|nuclear outer membrane|cytoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|inflammatory response|response to oxidative stress|regulation of blood pressure|positive regulation of vascular endothelial growth factor production|cytokine-mediated signaling pathway|cyclooxygenase pathway|lipoxygenase pathway|enzyme binding|heme binding|positive regulation of prostaglandin biosynthetic process|positive regulation of fever generation|NAD biosynthesis via nicotinamide riboside salvage pathway|long-chain fatty acid biosynthetic process|neuron projection|positive regulation of nitric oxide biosynthetic process|metal ion binding|regulation of inflammatory response|dioxygenase activity|oxidation-reduction process|cellular response to hypoxia|positive regulation of transforming growth factor beta production|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fibroblast growth factor production|positive regulation of brown fat cell differentiation|positive regulation of platelet-derived growth factor production|cellular oxidant detoxification|regulation of neuroinflammatory response "hsa00590,hsa04064,hsa04370,hsa04625,hsa04657,hsa04668,hsa04723,hsa04726,hsa04913,hsa04921,hsa04923,hsa05010,hsa05022,hsa05140,hsa05163,hsa05165,hsa05167,hsa05200,hsa05204,hsa05206,hsa05222" Arachidonic acid metabolism|NF-kappa B signaling pathway|VEGF signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Retrograde endocannabinoid signaling|Serotonergic synapse|Ovarian steroidogenesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Leishmaniasis|Human cytomegalovirus infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Chemical carcinogenesis|MicroRNAs in cancer|Small cell lung cancer PTH1R 18.77713969 13.52538047 24.0288989 1.776578407 0.829101362 0.356603408 1 0.150851556 0.263515007 5745 parathyroid hormone 1 receptor "GO:0001501,GO:0001701,GO:0002062,GO:0002076,GO:0004991,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0005887,GO:0006874,GO:0007166,GO:0007186,GO:0007187,GO:0007188,GO:0007189,GO:0007200,GO:0007204,GO:0007568,GO:0008284,GO:0008285,GO:0008528,GO:0016323,GO:0016324,GO:0017046,GO:0030282,GO:0031526,GO:0042803,GO:0043235,GO:0043621,GO:0045453,GO:0048469,GO:0060732" "skeletal system development|in utero embryonic development|chondrocyte differentiation|osteoblast development|parathyroid hormone receptor activity|protein binding|nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|aging|positive regulation of cell population proliferation|negative regulation of cell population proliferation|G protein-coupled peptide receptor activity|basolateral plasma membrane|apical plasma membrane|peptide hormone binding|bone mineralization|brush border membrane|protein homodimerization activity|receptor complex|protein self-association|bone resorption|cell maturation|positive regulation of inositol phosphate biosynthetic process" "hsa04080,hsa04928,hsa04961" "Neuroactive ligand-receptor interaction|Parathyroid hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption" PTHLH 177.7534868 149.8195991 205.6873746 1.372900314 0.457226875 0.230443815 1 2.504101675 3.380353675 5744 parathyroid hormone like hormone "GO:0001501,GO:0002076,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0007186,GO:0007189,GO:0007267,GO:0007565,GO:0008284,GO:0008285,GO:0008544,GO:0010468,GO:0030282,GO:0032330,GO:0032331,GO:0046058,GO:0051428,GO:0061182" skeletal system development|osteoblast development|hormone activity|protein binding|extracellular region|extracellular space|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|cell-cell signaling|female pregnancy|positive regulation of cell population proliferation|negative regulation of cell population proliferation|epidermis development|regulation of gene expression|bone mineralization|regulation of chondrocyte differentiation|negative regulation of chondrocyte differentiation|cAMP metabolic process|peptide hormone receptor binding|negative regulation of chondrocyte development hsa04928 "Parathyroid hormone synthesis, secretion and action" PTK2 5443.627066 5466.334539 5420.919592 0.991691883 -0.012036148 0.960974431 1 33.0420464 32.21920898 5747 protein tyrosine kinase 2 "GO:0000165,GO:0001525,GO:0001725,GO:0001890,GO:0001932,GO:0001934,GO:0003007,GO:0003779,GO:0004672,GO:0004713,GO:0004715,GO:0005102,GO:0005178,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0005938,GO:0007169,GO:0007172,GO:0007173,GO:0007179,GO:0007229,GO:0007411,GO:0008284,GO:0008360,GO:0008432,GO:0010594,GO:0010632,GO:0010759,GO:0010763,GO:0014068,GO:0018108,GO:0019901,GO:0019903,GO:0022408,GO:0030010,GO:0030154,GO:0030155,GO:0030335,GO:0031234,GO:0033628,GO:0035995,GO:0036064,GO:0038007,GO:0038083,GO:0038096,GO:0042127,GO:0042169,GO:0043066,GO:0043087,GO:0043197,GO:0043231,GO:0043552,GO:0045087,GO:0045667,GO:0045860,GO:0046777,GO:0048010,GO:0048013,GO:0048870,GO:0051493,GO:0051893,GO:0051897,GO:0060396,GO:0090303,GO:0120041,GO:1900024,GO:2000060,GO:2000811" MAPK cascade|angiogenesis|stress fiber|placenta development|regulation of protein phosphorylation|positive regulation of protein phosphorylation|heart morphogenesis|actin binding|protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|integrin binding|protein binding|ATP binding|nucleus|cytoplasm|cytosol|cytoskeleton|plasma membrane|focal adhesion|cell cortex|transmembrane receptor protein tyrosine kinase signaling pathway|signal complex assembly|epidermal growth factor receptor signaling pathway|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|axon guidance|positive regulation of cell population proliferation|regulation of cell shape|JUN kinase binding|regulation of endothelial cell migration|regulation of epithelial cell migration|positive regulation of macrophage chemotaxis|positive regulation of fibroblast migration|positive regulation of phosphatidylinositol 3-kinase signaling|peptidyl-tyrosine phosphorylation|protein kinase binding|protein phosphatase binding|negative regulation of cell-cell adhesion|establishment of cell polarity|cell differentiation|regulation of cell adhesion|positive regulation of cell migration|extrinsic component of cytoplasmic side of plasma membrane|regulation of cell adhesion mediated by integrin|detection of muscle stretch|ciliary basal body|netrin-activated signaling pathway|peptidyl-tyrosine autophosphorylation|Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of cell population proliferation|SH2 domain binding|negative regulation of apoptotic process|regulation of GTPase activity|dendritic spine|intracellular membrane-bounded organelle|positive regulation of phosphatidylinositol 3-kinase activity|innate immune response|regulation of osteoblast differentiation|positive regulation of protein kinase activity|protein autophosphorylation|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|cell motility|regulation of cytoskeleton organization|regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|growth hormone receptor signaling pathway|positive regulation of wound healing|positive regulation of macrophage proliferation|regulation of substrate adhesion-dependent cell spreading|positive regulation of ubiquitin-dependent protein catabolic process|negative regulation of anoikis "hsa01522,hsa04012,hsa04062,hsa04151,hsa04360,hsa04370,hsa04510,hsa04670,hsa04810,hsa04935,hsa05100,hsa05131,hsa05135,hsa05146,hsa05163,hsa05165,hsa05170,hsa05200,hsa05202,hsa05205,hsa05222,hsa05418" "Endocrine resistance|ErbB signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Axon guidance|VEGF signaling pathway|Focal adhesion|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Growth hormone synthesis, secretion and action|Bacterial invasion of epithelial cells|Shigellosis|Yersinia infection|Amoebiasis|Human cytomegalovirus infection|Human papillomavirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Proteoglycans in cancer|Small cell lung cancer|Fluid shear stress and atherosclerosis" PTK2B 707.5008321 671.0669543 743.9347099 1.108584926 0.148719296 0.563683289 1 7.004422058 7.635060005 2185 protein tyrosine kinase 2 beta "GO:0000165,GO:0001525,GO:0001556,GO:0001666,GO:0001954,GO:0002040,GO:0002250,GO:0002315,GO:0004683,GO:0004713,GO:0004715,GO:0004972,GO:0005102,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005925,GO:0005938,GO:0006468,GO:0006915,GO:0006968,GO:0006970,GO:0007165,GO:0007166,GO:0007169,GO:0007172,GO:0007173,GO:0007204,GO:0007229,GO:0008022,GO:0008284,GO:0008285,GO:0008360,GO:0009612,GO:0009725,GO:0009749,GO:0010226,GO:0010595,GO:0010656,GO:0010752,GO:0010758,GO:0010976,GO:0014009,GO:0014069,GO:0017146,GO:0018108,GO:0030027,GO:0030154,GO:0030155,GO:0030307,GO:0030335,GO:0030425,GO:0030426,GO:0030502,GO:0030838,GO:0031175,GO:0031234,GO:0031625,GO:0032960,GO:0033209,GO:0035235,GO:0035902,GO:0038083,GO:0038110,GO:0042127,GO:0042220,GO:0042493,GO:0042542,GO:0042976,GO:0043025,GO:0043066,GO:0043149,GO:0043197,GO:0043267,GO:0043423,GO:0043507,GO:0043524,GO:0043534,GO:0043552,GO:0044297,GO:0044877,GO:0045087,GO:0045121,GO:0045429,GO:0045453,GO:0045471,GO:0045638,GO:0045727,GO:0045766,GO:0045860,GO:0046330,GO:0046777,GO:0048010,GO:0048041,GO:0048167,GO:0048471,GO:0050731,GO:0050848,GO:0051000,GO:0051279,GO:0051591,GO:0051592,GO:0051968,GO:0060291,GO:0060292,GO:0065003,GO:0070098,GO:0070374,GO:0071300,GO:0071498,GO:0086100,GO:0090630,GO:0097440,GO:0098978,GO:2000058,GO:2000060,GO:2000114,GO:2000249,GO:2000310,GO:2000463,GO:2000538,GO:2000573" "MAPK cascade|angiogenesis|oocyte maturation|response to hypoxia|positive regulation of cell-matrix adhesion|sprouting angiogenesis|adaptive immune response|marginal zone B cell differentiation|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|NMDA glutamate receptor activity|signaling receptor binding|protein binding|ATP binding|nucleus|cytoplasm|cytosol|cytoskeleton|focal adhesion|cell cortex|protein phosphorylation|apoptotic process|cellular defense response|response to osmotic stress|signal transduction|cell surface receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|signal complex assembly|epidermal growth factor receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|integrin-mediated signaling pathway|protein C-terminus binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|regulation of cell shape|response to mechanical stimulus|response to hormone|response to glucose|response to lithium ion|positive regulation of endothelial cell migration|negative regulation of muscle cell apoptotic process|regulation of cGMP-mediated signaling|regulation of macrophage chemotaxis|positive regulation of neuron projection development|glial cell proliferation|postsynaptic density|NMDA selective glutamate receptor complex|peptidyl-tyrosine phosphorylation|lamellipodium|cell differentiation|regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell migration|dendrite|growth cone|negative regulation of bone mineralization|positive regulation of actin filament polymerization|neuron projection development|extrinsic component of cytoplasmic side of plasma membrane|ubiquitin protein ligase binding|regulation of inositol trisphosphate biosynthetic process|tumor necrosis factor-mediated signaling pathway|ionotropic glutamate receptor signaling pathway|response to immobilization stress|peptidyl-tyrosine autophosphorylation|interleukin-2-mediated signaling pathway|regulation of cell population proliferation|response to cocaine|response to drug|response to hydrogen peroxide|activation of Janus kinase activity|neuronal cell body|negative regulation of apoptotic process|stress fiber assembly|dendritic spine|negative regulation of potassium ion transport|3-phosphoinositide-dependent protein kinase binding|positive regulation of JUN kinase activity|negative regulation of neuron apoptotic process|blood vessel endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase activity|cell body|protein-containing complex binding|innate immune response|membrane raft|positive regulation of nitric oxide biosynthetic process|bone resorption|response to ethanol|negative regulation of myeloid cell differentiation|positive regulation of translation|positive regulation of angiogenesis|positive regulation of protein kinase activity|positive regulation of JNK cascade|protein autophosphorylation|vascular endothelial growth factor receptor signaling pathway|focal adhesion assembly|regulation of synaptic plasticity|perinuclear region of cytoplasm|positive regulation of peptidyl-tyrosine phosphorylation|regulation of calcium-mediated signaling|positive regulation of nitric-oxide synthase activity|regulation of release of sequestered calcium ion into cytosol|response to cAMP|response to calcium ion|positive regulation of synaptic transmission, glutamatergic|long-term synaptic potentiation|long-term synaptic depression|protein-containing complex assembly|chemokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|cellular response to retinoic acid|cellular response to fluid shear stress|endothelin receptor signaling pathway|activation of GTPase activity|apical dendrite|glutamatergic synapse|regulation of ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-dependent protein catabolic process|regulation of establishment of cell polarity|regulation of actin cytoskeleton reorganization|regulation of NMDA receptor activity|positive regulation of excitatory postsynaptic potential|positive regulation of B cell chemotaxis|positive regulation of DNA biosynthetic process" "hsa04020,hsa04062,hsa04072,hsa04650,hsa04670,hsa04912,hsa05135,hsa05161,hsa05163,hsa05170" Calcium signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Natural killer cell mediated cytotoxicity|Leukocyte transendothelial migration|GnRH signaling pathway|Yersinia infection|Hepatitis B|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection PTK6 283.8517795 222.6485709 345.0549882 1.549774098 0.632057938 0.049327264 1 4.059564406 6.186129579 5753 protein tyrosine kinase 6 "GO:0001726,GO:0004713,GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0007169,GO:0007260,GO:0009968,GO:0010976,GO:0016477,GO:0016604,GO:0030154,GO:0031234,GO:0038083,GO:0038128,GO:0042127,GO:0042531,GO:0042802,GO:0045087,GO:0045742,GO:0045787,GO:0045926,GO:0046777,GO:0060575,GO:0061099,GO:0071300" ruffle|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|tyrosine phosphorylation of STAT protein|negative regulation of signal transduction|positive regulation of neuron projection development|cell migration|nuclear body|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|peptidyl-tyrosine autophosphorylation|ERBB2 signaling pathway|regulation of cell population proliferation|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|innate immune response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of cell cycle|negative regulation of growth|protein autophosphorylation|intestinal epithelial cell differentiation|negative regulation of protein tyrosine kinase activity|cellular response to retinoic acid PTK7 2615.739778 2698.833612 2532.645944 0.938422411 -0.091690628 0.699129188 1 32.75683184 30.2253571 5754 protein tyrosine kinase 7 (inactive) "GO:0001736,GO:0001822,GO:0003281,GO:0003401,GO:0004672,GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0005911,GO:0005925,GO:0006468,GO:0007155,GO:0007165,GO:0010976,GO:0016477,GO:0031532,GO:0042060,GO:0045198,GO:0050839,GO:0060026,GO:0060484,GO:0060828,GO:0060976,GO:0071300,GO:0090103,GO:0090179,GO:0090263,GO:1904929" "establishment of planar polarity|kidney development|ventricular septum development|axis elongation|protein kinase activity|protein binding|ATP binding|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|protein phosphorylation|cell adhesion|signal transduction|positive regulation of neuron projection development|cell migration|actin cytoskeleton reorganization|wound healing|establishment of epithelial cell apical/basal polarity|cell adhesion molecule binding|convergent extension|lung-associated mesenchyme development|regulation of canonical Wnt signaling pathway|coronary vasculature development|cellular response to retinoic acid|cochlea morphogenesis|planar cell polarity pathway involved in neural tube closure|positive regulation of canonical Wnt signaling pathway|coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway" PTMA 14358.14028 13636.70476 15079.57579 1.105807896 0.145100778 0.578504665 1 597.5089243 649.673663 5757 prothymosin alpha "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0033613,GO:0043066" "protein binding|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|activating transcription factor binding|negative regulation of apoptotic process" PTMS 1878.400909 1635.530624 2121.271195 1.296992648 0.375170302 0.113315902 1 70.44815448 89.84177288 5763 parathymosin "GO:0002376,GO:0005634,GO:0006260" immune system process|nucleus|DNA replication PTN 561.1786426 438.0142446 684.3430407 1.562376222 0.643741898 0.01583025 0.741365292 11.60676028 17.83067623 5764 pleiotrophin "GO:0001889,GO:0002232,GO:0002690,GO:0004864,GO:0005178,GO:0005515,GO:0005576,GO:0005604,GO:0005615,GO:0005783,GO:0005886,GO:0007185,GO:0007229,GO:0007399,GO:0007406,GO:0007507,GO:0007612,GO:0007613,GO:0008083,GO:0008201,GO:0008284,GO:0008360,GO:0009986,GO:0010594,GO:0010811,GO:0010976,GO:0010996,GO:0014823,GO:0016525,GO:0019901,GO:0021510,GO:0021549,GO:0021794,GO:0030282,GO:0030324,GO:0030336,GO:0030501,GO:0031104,GO:0031594,GO:0031641,GO:0032355,GO:0032515,GO:0032570,GO:0032991,GO:0034644,GO:0035373,GO:0035374,GO:0036120,GO:0038085,GO:0042246,GO:0042493,GO:0043065,GO:0043113,GO:0043932,GO:0044849,GO:0045446,GO:0045545,GO:0045778,GO:0045837,GO:0046697,GO:0048167,GO:0048471,GO:0048477,GO:0048680,GO:0048714,GO:0050680,GO:0051781,GO:0060221,GO:0060253,GO:0060291,GO:0071305,GO:0071456,GO:0072201,GO:0098793,GO:0098794,GO:0140059,GO:1900006,GO:1900272,GO:1903706,GO:1904373,GO:1904389,GO:1904391,GO:1904395,GO:1904397,GO:1904399,GO:1990089,GO:2000036,GO:2000347,GO:2000738" liver development|leukocyte chemotaxis involved in inflammatory response|positive regulation of leukocyte chemotaxis|protein phosphatase inhibitor activity|integrin binding|protein binding|extracellular region|basement membrane|extracellular space|endoplasmic reticulum|plasma membrane|transmembrane receptor protein tyrosine phosphatase signaling pathway|integrin-mediated signaling pathway|nervous system development|negative regulation of neuroblast proliferation|heart development|learning|memory|growth factor activity|heparin binding|positive regulation of cell population proliferation|regulation of cell shape|cell surface|regulation of endothelial cell migration|positive regulation of cell-substrate adhesion|positive regulation of neuron projection development|response to auditory stimulus|response to activity|negative regulation of angiogenesis|protein kinase binding|spinal cord development|cerebellum development|thalamus development|bone mineralization|lung development|negative regulation of cell migration|positive regulation of bone mineralization|dendrite regeneration|neuromuscular junction|regulation of myelination|response to estradiol|negative regulation of phosphoprotein phosphatase activity|response to progesterone|protein-containing complex|cellular response to UV|chondroitin sulfate proteoglycan binding|chondroitin sulfate binding|cellular response to platelet-derived growth factor stimulus|vascular endothelial growth factor binding|tissue regeneration|response to drug|positive regulation of apoptotic process|receptor clustering|ossification involved in bone remodeling|estrous cycle|endothelial cell differentiation|syndecan binding|positive regulation of ossification|negative regulation of membrane potential|decidualization|regulation of synaptic plasticity|perinuclear region of cytoplasm|oogenesis|positive regulation of axon regeneration|positive regulation of oligodendrocyte differentiation|negative regulation of epithelial cell proliferation|positive regulation of cell division|retinal rod cell differentiation|negative regulation of glial cell proliferation|long-term synaptic potentiation|cellular response to vitamin D|cellular response to hypoxia|negative regulation of mesenchymal cell proliferation|presynapse|postsynapse|dendrite arborization|positive regulation of dendrite development|negative regulation of long-term synaptic potentiation|regulation of hemopoiesis|response to kainic acid|rod bipolar cell differentiation|response to ciliary neurotrophic factor|positive regulation of skeletal muscle acetylcholine-gated channel clustering|negative regulation of neuromuscular junction development|heparan sulfate binding|response to nerve growth factor|regulation of stem cell population maintenance|positive regulation of hepatocyte proliferation|positive regulation of stem cell differentiation PTOV1 1348.103174 1188.152654 1508.053695 1.269242374 0.343967592 0.151991044 1 13.3157336 16.61807976 53635 PTOV1 extended AT-hook containing adaptor protein "GO:0005654,GO:0005667,GO:0005886,GO:0045944,GO:0048471" nucleoplasm|transcription regulator complex|plasma membrane|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm PTP4A1 2295.452776 2554.216082 2036.689471 0.797383387 -0.326654547 0.166999884 1 22.72654516 17.81852628 7803 protein tyrosine phosphatase 4A1 "GO:0004725,GO:0005515,GO:0005634,GO:0005737,GO:0005769,GO:0005783,GO:0005819,GO:0007049,GO:0007275,GO:0008138,GO:0009898,GO:0030335,GO:0035335" protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|early endosome|endoplasmic reticulum|spindle|cell cycle|multicellular organism development|protein tyrosine/serine/threonine phosphatase activity|cytoplasmic side of plasma membrane|positive regulation of cell migration|peptidyl-tyrosine dephosphorylation PTP4A2 3978.680505 4036.805865 3920.555144 0.971202301 -0.042156255 0.8603923 1 51.49065718 49.17103118 8073 protein tyrosine phosphatase 4A2 "GO:0004725,GO:0004727,GO:0005515,GO:0005634,GO:0005737,GO:0005769,GO:0005829,GO:0005886,GO:0035335,GO:0043687" protein tyrosine phosphatase activity|prenylated protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|early endosome|cytosol|plasma membrane|peptidyl-tyrosine dephosphorylation|post-translational protein modification PTP4A3 10.88974722 8.323311061 13.45618338 1.616686351 0.693039812 0.572357607 1 0.124043511 0.197183695 11156 protein tyrosine phosphatase 4A3 "GO:0004725,GO:0004727,GO:0005515,GO:0005634,GO:0005737,GO:0005769,GO:0005886,GO:0006355,GO:0008138,GO:0035335,GO:0043542,GO:1901224,GO:1904951" "protein tyrosine phosphatase activity|prenylated protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|early endosome|plasma membrane|regulation of transcription, DNA-templated|protein tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|endothelial cell migration|positive regulation of NIK/NF-kappaB signaling|positive regulation of establishment of protein localization" PTPA 2311.095426 2296.193439 2325.997414 1.012979732 0.018605308 0.939192706 1 39.03906455 38.88403604 5524 protein phosphatase 2 phosphatase activator "GO:0000159,GO:0000413,GO:0003755,GO:0005102,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0007052,GO:0008160,GO:0016887,GO:0019888,GO:0032515,GO:0032516,GO:0034704,GO:0035307,GO:0035308,GO:0042803,GO:0043065,GO:0043666,GO:0051721,GO:0070062" protein phosphatase type 2A complex|protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|signaling receptor binding|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitotic spindle organization|protein tyrosine phosphatase activator activity|ATPase activity|protein phosphatase regulator activity|negative regulation of phosphoprotein phosphatase activity|positive regulation of phosphoprotein phosphatase activity|calcium channel complex|positive regulation of protein dephosphorylation|negative regulation of protein dephosphorylation|protein homodimerization activity|positive regulation of apoptotic process|regulation of phosphoprotein phosphatase activity|protein phosphatase 2A binding|extracellular exosome hsa04931 Insulin resistance PTPDC1 680.1022426 784.4720675 575.7324176 0.733910666 -0.44632363 0.082691891 1 4.591558724 3.313404984 138639 protein tyrosine phosphatase domain containing 1 "GO:0004725,GO:0005515,GO:0005654,GO:0005737,GO:0008138,GO:0035335,GO:0060271" protein tyrosine phosphatase activity|protein binding|nucleoplasm|cytoplasm|protein tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|cilium assembly PTPMT1 550.6499721 527.4898385 573.8101057 1.087812625 0.121430074 0.654235696 1 11.43426612 12.23020028 114971 protein tyrosine phosphatase mitochondrial 1 "GO:0004439,GO:0004725,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0008138,GO:0008962,GO:0032049,GO:0035335,GO:0106306,GO:0106307,GO:2001242" "phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|protein tyrosine/serine/threonine phosphatase activity|phosphatidylglycerophosphatase activity|cardiolipin biosynthetic process|peptidyl-tyrosine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity|regulation of intrinsic apoptotic signaling pathway" PTPN1 3682.581532 3795.429844 3569.733221 0.940534634 -0.088447024 0.710396494 1 50.90603545 47.07770107 5770 protein tyrosine phosphatase non-receptor type 1 "GO:0003723,GO:0004725,GO:0005158,GO:0005515,GO:0005759,GO:0005769,GO:0005783,GO:0005829,GO:0005886,GO:0006470,GO:0007257,GO:0008270,GO:0008286,GO:0009966,GO:0009968,GO:0019899,GO:0019901,GO:0030061,GO:0030100,GO:0030948,GO:0030968,GO:0030971,GO:0031532,GO:0032991,GO:0033157,GO:0034620,GO:0035335,GO:0035791,GO:0036498,GO:0043407,GO:0045296,GO:0046627,GO:0046875,GO:0051721,GO:0060338,GO:0060397,GO:0061098,GO:0070373,GO:0097443,GO:0098554,GO:1902202,GO:1902236,GO:1903896,GO:1903898,GO:1990264,GO:2000646" RNA binding|protein tyrosine phosphatase activity|insulin receptor binding|protein binding|mitochondrial matrix|early endosome|endoplasmic reticulum|cytosol|plasma membrane|protein dephosphorylation|activation of JUN kinase activity|zinc ion binding|insulin receptor signaling pathway|regulation of signal transduction|negative regulation of signal transduction|enzyme binding|protein kinase binding|mitochondrial crista|regulation of endocytosis|negative regulation of vascular endothelial growth factor receptor signaling pathway|endoplasmic reticulum unfolded protein response|receptor tyrosine kinase binding|actin cytoskeleton reorganization|protein-containing complex|regulation of intracellular protein transport|cellular response to unfolded protein|peptidyl-tyrosine dephosphorylation|platelet-derived growth factor receptor-beta signaling pathway|IRE1-mediated unfolded protein response|negative regulation of MAP kinase activity|cadherin binding|negative regulation of insulin receptor signaling pathway|ephrin receptor binding|protein phosphatase 2A binding|regulation of type I interferon-mediated signaling pathway|growth hormone receptor signaling pathway via JAK-STAT|positive regulation of protein tyrosine kinase activity|negative regulation of ERK1 and ERK2 cascade|sorting endosome|cytoplasmic side of endoplasmic reticulum membrane|regulation of hepatocyte growth factor receptor signaling pathway|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of IRE1-mediated unfolded protein response|negative regulation of PERK-mediated unfolded protein response|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity|positive regulation of receptor catabolic process "hsa04520,hsa04910,hsa04931" Adherens junction|Insulin signaling pathway|Insulin resistance PTPN11 5413.914291 5657.770694 5170.057887 0.913797707 -0.130053272 0.589530268 1 47.09792909 42.31779731 5781 protein tyrosine phosphatase non-receptor type 11 "GO:0000077,GO:0000187,GO:0001784,GO:0004721,GO:0004725,GO:0004726,GO:0005158,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006641,GO:0007173,GO:0007229,GO:0007411,GO:0007420,GO:0007507,GO:0008543,GO:0009755,GO:0019221,GO:0019901,GO:0019904,GO:0021697,GO:0030159,GO:0030168,GO:0030220,GO:0030971,GO:0031295,GO:0031748,GO:0032331,GO:0032528,GO:0032728,GO:0032755,GO:0032760,GO:0032991,GO:0033277,GO:0033628,GO:0033629,GO:0035264,GO:0035265,GO:0035335,GO:0035855,GO:0036302,GO:0038127,GO:0042445,GO:0042593,GO:0043254,GO:0043274,GO:0043560,GO:0045296,GO:0045778,GO:0045931,GO:0046326,GO:0046628,GO:0046676,GO:0046825,GO:0046887,GO:0048008,GO:0048011,GO:0048013,GO:0048609,GO:0048806,GO:0048839,GO:0048873,GO:0050731,GO:0050839,GO:0050900,GO:0051428,GO:0051463,GO:0051897,GO:0060020,GO:0060125,GO:0060325,GO:0060338,GO:0061582,GO:0070102,GO:0070374,GO:0071260,GO:0071345,GO:0071364,GO:1990782" DNA damage checkpoint|activation of MAPK activity|phosphotyrosine residue binding|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|insulin receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|triglyceride metabolic process|epidermal growth factor receptor signaling pathway|integrin-mediated signaling pathway|axon guidance|brain development|heart development|fibroblast growth factor receptor signaling pathway|hormone-mediated signaling pathway|cytokine-mediated signaling pathway|protein kinase binding|protein domain specific binding|cerebellar cortex formation|signaling receptor complex adaptor activity|platelet activation|platelet formation|receptor tyrosine kinase binding|T cell costimulation|D1 dopamine receptor binding|negative regulation of chondrocyte differentiation|microvillus organization|positive regulation of interferon-beta production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|protein-containing complex|abortive mitotic cell cycle|regulation of cell adhesion mediated by integrin|negative regulation of cell adhesion mediated by integrin|multicellular organism growth|organ growth|peptidyl-tyrosine dephosphorylation|megakaryocyte development|atrioventricular canal development|ERBB signaling pathway|hormone metabolic process|glucose homeostasis|regulation of protein-containing complex assembly|phospholipase binding|insulin receptor substrate binding|cadherin binding|positive regulation of ossification|positive regulation of mitotic cell cycle|positive regulation of glucose import|positive regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|regulation of protein export from nucleus|positive regulation of hormone secretion|platelet-derived growth factor receptor signaling pathway|neurotrophin TRK receptor signaling pathway|ephrin receptor signaling pathway|multicellular organismal reproductive process|genitalia development|inner ear development|homeostasis of number of cells within a tissue|positive regulation of peptidyl-tyrosine phosphorylation|cell adhesion molecule binding|leukocyte migration|peptide hormone receptor binding|negative regulation of cortisol secretion|positive regulation of protein kinase B signaling|Bergmann glial cell differentiation|negative regulation of growth hormone secretion|face morphogenesis|regulation of type I interferon-mediated signaling pathway|intestinal epithelial cell migration|interleukin-6-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|cellular response to mechanical stimulus|cellular response to cytokine stimulus|cellular response to epidermal growth factor stimulus|protein tyrosine kinase binding "hsa04014,hsa04072,hsa04360,hsa04625,hsa04630,hsa04650,hsa04670,hsa04722,hsa04920,hsa04931,hsa05120,hsa05130,hsa05168,hsa05205,hsa05211,hsa05220,hsa05235" Ras signaling pathway|Phospholipase D signaling pathway|Axon guidance|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Adipocytokine signaling pathway|Insulin resistance|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Herpes simplex virus 1 infection|Proteoglycans in cancer|Renal cell carcinoma|Chronic myeloid leukemia|PD-L1 expression and PD-1 checkpoint pathway in cancer PTPN12 4198.126003 4082.584075 4313.66793 1.056602351 0.079432524 0.739726568 1 61.16788564 63.54863401 5782 protein tyrosine phosphatase non-receptor type 12 "GO:0002102,GO:0004721,GO:0004725,GO:0004726,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005925,GO:0006470,GO:0017124,GO:0035335,GO:0038128,GO:0042058,GO:0042246,GO:0042995,GO:0071345,GO:0071364,GO:1901185,GO:2000587" podosome|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|focal adhesion|protein dephosphorylation|SH3 domain binding|peptidyl-tyrosine dephosphorylation|ERBB2 signaling pathway|regulation of epidermal growth factor receptor signaling pathway|tissue regeneration|cell projection|cellular response to cytokine stimulus|cellular response to epidermal growth factor stimulus|negative regulation of ERBB signaling pathway|negative regulation of platelet-derived growth factor receptor-beta signaling pathway PTPN13 809.8476214 910.3621473 709.3330955 0.779176834 -0.359977311 0.151837485 1 5.678395819 4.350436887 5783 protein tyrosine phosphatase non-receptor type 13 "GO:0001650,GO:0001933,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006470,GO:0006661,GO:0014066,GO:0030027,GO:0035335,GO:0036312,GO:0043005,GO:0044297,GO:0070062,GO:0071345" fibrillar center|negative regulation of protein phosphorylation|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|plasma membrane|protein dephosphorylation|phosphatidylinositol biosynthetic process|regulation of phosphatidylinositol 3-kinase signaling|lamellipodium|peptidyl-tyrosine dephosphorylation|phosphatidylinositol 3-kinase regulatory subunit binding|neuron projection|cell body|extracellular exosome|cellular response to cytokine stimulus hsa04210 Apoptosis PTPN14 3440.359556 3921.319924 2959.399189 0.754694655 -0.406035038 0.087187047 1 15.40022351 11.42798014 5784 protein tyrosine phosphatase non-receptor type 14 "GO:0001946,GO:0003712,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005856,GO:0006355,GO:0006470,GO:0008285,GO:0030971,GO:0035335,GO:0046825,GO:0071345" "lymphangiogenesis|transcription coregulator activity|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytoskeleton|regulation of transcription, DNA-templated|protein dephosphorylation|negative regulation of cell population proliferation|receptor tyrosine kinase binding|peptidyl-tyrosine dephosphorylation|regulation of protein export from nucleus|cellular response to cytokine stimulus" PTPN18 757.034348 785.5124814 728.5562146 0.927491583 -0.108593906 0.67159936 1 11.45392279 10.44564848 26469 protein tyrosine phosphatase non-receptor type 18 "GO:0001825,GO:0004725,GO:0004726,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006470,GO:0035335,GO:0038128,GO:0071345,GO:1901185" blastocyst formation|protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein dephosphorylation|peptidyl-tyrosine dephosphorylation|ERBB2 signaling pathway|cellular response to cytokine stimulus|negative regulation of ERBB signaling pathway PTPN2 787.3057302 797.997448 776.6140124 0.973203629 -0.039186395 0.881420097 1 9.716554219 9.297949365 5771 protein tyrosine phosphatase non-receptor type 2 "GO:0000122,GO:0004725,GO:0004726,GO:0005178,GO:0005515,GO:0005654,GO:0005783,GO:0005793,GO:0005829,GO:0005886,GO:0008285,GO:0008286,GO:0010804,GO:0010888,GO:0019901,GO:0019905,GO:0030183,GO:0030217,GO:0030218,GO:0030971,GO:0035335,GO:0042059,GO:0042532,GO:0042593,GO:0045650,GO:0045722,GO:0046627,GO:0050728,GO:0050860,GO:0050922,GO:0060334,GO:0060336,GO:0060339,GO:0061099,GO:0070104,GO:0070373,GO:0071345,GO:0097677,GO:1902202,GO:1902206,GO:1902215,GO:1902227,GO:1902233,GO:1902237,GO:1903899,GO:2000587" negative regulation of transcription by RNA polymerase II|protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|integrin binding|protein binding|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cytosol|plasma membrane|negative regulation of cell population proliferation|insulin receptor signaling pathway|negative regulation of tumor necrosis factor-mediated signaling pathway|negative regulation of lipid storage|protein kinase binding|syntaxin binding|B cell differentiation|T cell differentiation|erythrocyte differentiation|receptor tyrosine kinase binding|peptidyl-tyrosine dephosphorylation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of tyrosine phosphorylation of STAT protein|glucose homeostasis|negative regulation of macrophage differentiation|positive regulation of gluconeogenesis|negative regulation of insulin receptor signaling pathway|negative regulation of inflammatory response|negative regulation of T cell receptor signaling pathway|negative regulation of chemotaxis|regulation of interferon-gamma-mediated signaling pathway|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of type I interferon-mediated signaling pathway|negative regulation of protein tyrosine kinase activity|negative regulation of interleukin-6-mediated signaling pathway|negative regulation of ERK1 and ERK2 cascade|cellular response to cytokine stimulus|STAT family protein binding|regulation of hepatocyte growth factor receptor signaling pathway|negative regulation of interleukin-2-mediated signaling pathway|negative regulation of interleukin-4-mediated signaling pathway|negative regulation of macrophage colony-stimulating factor signaling pathway|negative regulation of positive thymic T cell selection|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of PERK-mediated unfolded protein response|negative regulation of platelet-derived growth factor receptor-beta signaling pathway hsa04630 JAK-STAT signaling pathway PTPN21 728.0612752 731.4109595 724.7115908 0.990840486 -0.013275276 0.964384199 1 5.390699991 5.25194398 11099 protein tyrosine phosphatase non-receptor type 21 "GO:0004725,GO:0005515,GO:0005737,GO:0005856,GO:0006470,GO:0035335" protein tyrosine phosphatase activity|protein binding|cytoplasm|cytoskeleton|protein dephosphorylation|peptidyl-tyrosine dephosphorylation PTPN22 30.98470354 31.21241648 30.75699059 0.985408823 -0.021205706 1 1 0.299379817 0.290074895 26191 protein tyrosine phosphatase non-receptor type 22 "GO:0002230,GO:0004725,GO:0004726,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006470,GO:0006914,GO:0009898,GO:0010507,GO:0010628,GO:0010629,GO:0016791,GO:0017124,GO:0019900,GO:0030217,GO:0031625,GO:0031663,GO:0032481,GO:0032496,GO:0032715,GO:0032717,GO:0032720,GO:0032729,GO:0032817,GO:0034141,GO:0034145,GO:0034157,GO:0034165,GO:0035335,GO:0035644,GO:0043508,GO:0045088,GO:0048471,GO:0050852,GO:0050855,GO:0050860,GO:0050868,GO:0070374,GO:0070433,GO:0071225,GO:0071663,GO:1901222,GO:1902523,GO:1903753,GO:2000566" "positive regulation of defense response to virus by host|protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|cytosol|protein dephosphorylation|autophagy|cytoplasmic side of plasma membrane|negative regulation of autophagy|positive regulation of gene expression|negative regulation of gene expression|phosphatase activity|SH3 domain binding|kinase binding|T cell differentiation|ubiquitin protein ligase binding|lipopolysaccharide-mediated signaling pathway|positive regulation of type I interferon production|response to lipopolysaccharide|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of tumor necrosis factor production|positive regulation of interferon-gamma production|regulation of natural killer cell proliferation|positive regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of toll-like receptor 7 signaling pathway|positive regulation of toll-like receptor 9 signaling pathway|peptidyl-tyrosine dephosphorylation|phosphoanandamide dephosphorylation|negative regulation of JUN kinase activity|regulation of innate immune response|perinuclear region of cytoplasm|T cell receptor signaling pathway|regulation of B cell receptor signaling pathway|negative regulation of T cell receptor signaling pathway|negative regulation of T cell activation|positive regulation of ERK1 and ERK2 cascade|negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|cellular response to muramyl dipeptide|positive regulation of granzyme B production|regulation of NIK/NF-kappaB signaling|positive regulation of protein K63-linked ubiquitination|negative regulation of p38MAPK cascade|positive regulation of CD8-positive, alpha-beta T cell proliferation" PTPN23 901.5235444 995.6760857 807.371003 0.810877166 -0.302444707 0.22325073 1 10.1079328 8.05913806 25930 protein tyrosine phosphatase non-receptor type 23 "GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0010633,GO:0015031,GO:0016604,GO:0019901,GO:0032456,GO:0035335,GO:0036064,GO:0043162,GO:0043231,GO:0045022,GO:0060271,GO:0061357,GO:0070062,GO:0071345,GO:1903387,GO:1903393,GO:2000643" protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|endosome|early endosome|cytosol|negative regulation of epithelial cell migration|protein transport|nuclear body|protein kinase binding|endocytic recycling|peptidyl-tyrosine dephosphorylation|ciliary basal body|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|intracellular membrane-bounded organelle|early endosome to late endosome transport|cilium assembly|positive regulation of Wnt protein secretion|extracellular exosome|cellular response to cytokine stimulus|positive regulation of homophilic cell adhesion|positive regulation of adherens junction organization|positive regulation of early endosome to late endosome transport PTPN3 1015.71805 953.0191165 1078.416983 1.131579592 0.178338063 0.46884525 1 4.563560222 5.077618537 5774 protein tyrosine phosphatase non-receptor type 3 "GO:0001784,GO:0004725,GO:0005515,GO:0005737,GO:0005856,GO:0005886,GO:0006470,GO:0008092,GO:0009898,GO:0017080,GO:0035335,GO:0042059,GO:0045930,GO:0051045,GO:0051117,GO:0097421,GO:0098902,GO:2000649" phosphotyrosine residue binding|protein tyrosine phosphatase activity|protein binding|cytoplasm|cytoskeleton|plasma membrane|protein dephosphorylation|cytoskeletal protein binding|cytoplasmic side of plasma membrane|sodium channel regulator activity|peptidyl-tyrosine dephosphorylation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of mitotic cell cycle|negative regulation of membrane protein ectodomain proteolysis|ATPase binding|liver regeneration|regulation of membrane depolarization during action potential|regulation of sodium ion transmembrane transporter activity PTPN4 434.9401199 454.6608667 415.219373 0.91325074 -0.130917077 0.648470423 1 2.187954448 1.964714667 5775 protein tyrosine phosphatase non-receptor type 4 "GO:0004725,GO:0004726,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006470,GO:0008092,GO:0009898,GO:0035335,GO:0071345" protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|protein binding|nucleoplasm|cytoplasm|cytosol|cytoskeleton|protein dephosphorylation|cytoskeletal protein binding|cytoplasmic side of plasma membrane|peptidyl-tyrosine dephosphorylation|cellular response to cytokine stimulus PTPN6 263.2460627 274.669265 251.8228605 0.91682213 -0.125286228 0.7118614 1 5.618472155 5.064942261 5777 protein tyrosine phosphatase non-receptor type 6 "GO:0001784,GO:0002244,GO:0002924,GO:0004725,GO:0005001,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005911,GO:0006470,GO:0007186,GO:0008284,GO:0008285,GO:0014068,GO:0016020,GO:0017124,GO:0018108,GO:0019221,GO:0019901,GO:0030154,GO:0030168,GO:0030220,GO:0031295,GO:0032715,GO:0032720,GO:0032991,GO:0033277,GO:0033630,GO:0035335,GO:0035556,GO:0035580,GO:0035855,GO:0042105,GO:0042130,GO:0042169,GO:0042267,GO:0042981,GO:0043312,GO:0043407,GO:0045577,GO:0050732,GO:0050839,GO:0050853,GO:0050860,GO:0050900,GO:0051279,GO:0060338,GO:0070062,GO:0070372,GO:0070527,GO:0071345,GO:0140031,GO:1904724,GO:1905867,GO:2000045" phosphotyrosine residue binding|hematopoietic progenitor cell differentiation|negative regulation of humoral immune response mediated by circulating immunoglobulin|protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|extracellular region|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|cell-cell junction|protein dephosphorylation|G protein-coupled receptor signaling pathway|positive regulation of cell population proliferation|negative regulation of cell population proliferation|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|SH3 domain binding|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|protein kinase binding|cell differentiation|platelet activation|platelet formation|T cell costimulation|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|protein-containing complex|abortive mitotic cell cycle|positive regulation of cell adhesion mediated by integrin|peptidyl-tyrosine dephosphorylation|intracellular signal transduction|specific granule lumen|megakaryocyte development|alpha-beta T cell receptor complex|negative regulation of T cell proliferation|SH2 domain binding|natural killer cell mediated cytotoxicity|regulation of apoptotic process|neutrophil degranulation|negative regulation of MAP kinase activity|regulation of B cell differentiation|negative regulation of peptidyl-tyrosine phosphorylation|cell adhesion molecule binding|B cell receptor signaling pathway|negative regulation of T cell receptor signaling pathway|leukocyte migration|regulation of release of sequestered calcium ion into cytosol|regulation of type I interferon-mediated signaling pathway|extracellular exosome|regulation of ERK1 and ERK2 cascade|platelet aggregation|cellular response to cytokine stimulus|phosphorylation-dependent protein binding|tertiary granule lumen|epididymis development|regulation of G1/S transition of mitotic cell cycle "hsa04520,hsa04630,hsa04650,hsa04660,hsa04662,hsa05130,hsa05140,hsa05205,hsa05235" Adherens junction|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Pathogenic Escherichia coli infection|Leishmaniasis|Proteoglycans in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer PTPN9 1893.405809 1966.382238 1820.429381 0.925775948 -0.111265014 0.639667231 1 13.38719301 12.18615217 5780 protein tyrosine phosphatase non-receptor type 9 "GO:0004725,GO:0004726,GO:0005515,GO:0005654,GO:0005737,GO:0006470,GO:0010977,GO:0035335,GO:0044306,GO:0071345,GO:1903078" protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|protein binding|nucleoplasm|cytoplasm|protein dephosphorylation|negative regulation of neuron projection development|peptidyl-tyrosine dephosphorylation|neuron projection terminus|cellular response to cytokine stimulus|positive regulation of protein localization to plasma membrane PTPRA 2505.480444 2516.761182 2494.199706 0.991035512 -0.012991341 0.95799362 1 31.07702885 30.28306901 5786 protein tyrosine phosphatase receptor type A "GO:0000165,GO:0004725,GO:0005001,GO:0005515,GO:0005886,GO:0005887,GO:0005925,GO:0006468,GO:0006470,GO:0007229,GO:0007411,GO:0008286,GO:0016020,GO:0035335,GO:0043235,GO:0050804,GO:0051893,GO:0070062,GO:0098685,GO:0099699" MAPK cascade|protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|plasma membrane|integral component of plasma membrane|focal adhesion|protein phosphorylation|protein dephosphorylation|integrin-mediated signaling pathway|axon guidance|insulin receptor signaling pathway|membrane|peptidyl-tyrosine dephosphorylation|receptor complex|modulation of chemical synaptic transmission|regulation of focal adhesion assembly|extracellular exosome|Schaffer collateral - CA1 synapse|integral component of synaptic membrane PTPRB 36.98438263 49.93986637 24.0288989 0.481156652 -1.055421421 0.116129878 1 0.201863128 0.095502485 5787 protein tyrosine phosphatase receptor type B "GO:0001525,GO:0005001,GO:0005515,GO:0005886,GO:0005887,GO:0006470,GO:0006796,GO:0016311,GO:0035579,GO:0043235,GO:0043312,GO:0045296,GO:0070821,GO:1990264" angiogenesis|transmembrane receptor protein tyrosine phosphatase activity|protein binding|plasma membrane|integral component of plasma membrane|protein dephosphorylation|phosphate-containing compound metabolic process|dephosphorylation|specific granule membrane|receptor complex|neutrophil degranulation|cadherin binding|tertiary granule membrane|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity hsa04520 Adherens junction PTPRD 49.32592463 33.29324424 65.35860501 1.96311914 0.973147731 0.107792371 1 0.157797447 0.30459152 5789 protein tyrosine phosphatase receptor type D "GO:0004725,GO:0005001,GO:0005102,GO:0005515,GO:0005886,GO:0005887,GO:0006470,GO:0006796,GO:0007157,GO:0007185,GO:0030182,GO:0035335,GO:0046426,GO:0050775,GO:0050776,GO:0050804,GO:0050839,GO:0051965,GO:0070062,GO:0097105,GO:0098685,GO:0098686,GO:0098978,GO:0099056,GO:0099151,GO:0099545,GO:0099560,GO:1905606" protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|signaling receptor binding|protein binding|plasma membrane|integral component of plasma membrane|protein dephosphorylation|phosphate-containing compound metabolic process|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|transmembrane receptor protein tyrosine phosphatase signaling pathway|neuron differentiation|peptidyl-tyrosine dephosphorylation|negative regulation of receptor signaling pathway via JAK-STAT|positive regulation of dendrite morphogenesis|regulation of immune response|modulation of chemical synaptic transmission|cell adhesion molecule binding|positive regulation of synapse assembly|extracellular exosome|presynaptic membrane assembly|Schaffer collateral - CA1 synapse|hippocampal mossy fiber to CA3 synapse|glutamatergic synapse|integral component of presynaptic membrane|regulation of postsynaptic density assembly|trans-synaptic signaling by trans-synaptic complex|synaptic membrane adhesion|regulation of presynapse assembly PTPRE 360.3819506 326.6899591 394.073942 1.206262791 0.270544241 0.365684832 1 1.995289848 2.366568628 5791 protein tyrosine phosphatase receptor type E "GO:0004725,GO:0005001,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0006470,GO:0016021,GO:0035335,GO:0046627" protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|plasma membrane|protein dephosphorylation|integral component of membrane|peptidyl-tyrosine dephosphorylation|negative regulation of insulin receptor signaling pathway PTPRF 9949.387372 11178.20676 8720.567989 0.780140158 -0.358194756 0.154137165 1 79.04602489 60.63506501 5792 protein tyrosine phosphatase receptor type F "GO:0004725,GO:0005001,GO:0005886,GO:0005887,GO:0006470,GO:0007155,GO:0007185,GO:0008201,GO:0016477,GO:0031102,GO:0035335,GO:0035373,GO:0043005,GO:0043025,GO:0044877,GO:0048679,GO:0050839,GO:0070062,GO:0099560,GO:1900121" protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|plasma membrane|integral component of plasma membrane|protein dephosphorylation|cell adhesion|transmembrane receptor protein tyrosine phosphatase signaling pathway|heparin binding|cell migration|neuron projection regeneration|peptidyl-tyrosine dephosphorylation|chondroitin sulfate proteoglycan binding|neuron projection|neuronal cell body|protein-containing complex binding|regulation of axon regeneration|cell adhesion molecule binding|extracellular exosome|synaptic membrane adhesion|negative regulation of receptor binding "hsa04514,hsa04520,hsa04910,hsa04931" Cell adhesion molecules|Adherens junction|Insulin signaling pathway|Insulin resistance PTPRG 622.7555617 679.3902654 566.1208581 0.833277848 -0.263130468 0.314391207 1 3.39301982 2.780016743 5793 protein tyrosine phosphatase receptor type G "GO:0004725,GO:0005001,GO:0005515,GO:0005887,GO:0006470,GO:0007169,GO:0007420,GO:0010633,GO:0010977,GO:0035335,GO:0042802,GO:0070062,GO:1903385" protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|integral component of plasma membrane|protein dephosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|brain development|negative regulation of epithelial cell migration|negative regulation of neuron projection development|peptidyl-tyrosine dephosphorylation|identical protein binding|extracellular exosome|regulation of homophilic cell adhesion PTPRH 389.8846768 457.7821084 321.9872453 0.703363542 -0.507657538 0.081058821 1 5.498759792 3.802907662 5794 protein tyrosine phosphatase receptor type H "GO:0004725,GO:0005001,GO:0005515,GO:0005737,GO:0005887,GO:0006470,GO:0006915,GO:0016324,GO:0031528,GO:0035335,GO:0045296" protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|cytoplasm|integral component of plasma membrane|protein dephosphorylation|apoptotic process|apical plasma membrane|microvillus membrane|peptidyl-tyrosine dephosphorylation|cadherin binding PTPRJ 1407.548962 1550.216685 1264.881238 0.815938346 -0.293467952 0.220360275 1 8.598234807 6.898232429 5795 protein tyrosine phosphatase receptor type J "GO:0001772,GO:0004725,GO:0005161,GO:0005515,GO:0005886,GO:0005887,GO:0005911,GO:0006470,GO:0008013,GO:0008285,GO:0009986,GO:0010642,GO:0016791,GO:0019901,GO:0030155,GO:0030183,GO:0030308,GO:0030336,GO:0032587,GO:0032760,GO:0035335,GO:0035579,GO:0035584,GO:0042059,GO:0043116,GO:0043312,GO:0043407,GO:0043410,GO:0045295,GO:0045296,GO:0045785,GO:0048008,GO:0050731,GO:0050852,GO:0050860,GO:0050918,GO:0051019,GO:0051894,GO:0051897,GO:0051898,GO:0060242,GO:0070062,GO:0070097,GO:1905451" immunological synapse|protein tyrosine phosphatase activity|platelet-derived growth factor receptor binding|protein binding|plasma membrane|integral component of plasma membrane|cell-cell junction|protein dephosphorylation|beta-catenin binding|negative regulation of cell population proliferation|cell surface|negative regulation of platelet-derived growth factor receptor signaling pathway|phosphatase activity|protein kinase binding|regulation of cell adhesion|B cell differentiation|negative regulation of cell growth|negative regulation of cell migration|ruffle membrane|positive regulation of tumor necrosis factor production|peptidyl-tyrosine dephosphorylation|specific granule membrane|calcium-mediated signaling using intracellular calcium source|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of vascular permeability|neutrophil degranulation|negative regulation of MAP kinase activity|positive regulation of MAPK cascade|gamma-catenin binding|cadherin binding|positive regulation of cell adhesion|platelet-derived growth factor receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|T cell receptor signaling pathway|negative regulation of T cell receptor signaling pathway|positive chemotaxis|mitogen-activated protein kinase binding|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|negative regulation of protein kinase B signaling|contact inhibition|extracellular exosome|delta-catenin binding|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis hsa04520 Adherens junction PTPRK 903.4408259 1008.161052 798.7205994 0.792254965 -0.335963299 0.175868946 1 6.509824856 5.071138274 5796 protein tyrosine phosphatase receptor type K "GO:0004725,GO:0005001,GO:0005515,GO:0005886,GO:0005887,GO:0005911,GO:0005912,GO:0006470,GO:0007155,GO:0007165,GO:0007179,GO:0008013,GO:0008285,GO:0009986,GO:0010839,GO:0016021,GO:0016477,GO:0019901,GO:0030054,GO:0030336,GO:0031256,GO:0034394,GO:0034614,GO:0034644,GO:0035335,GO:0043231,GO:0045295,GO:0045786,GO:0045892,GO:0048041" "protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|plasma membrane|integral component of plasma membrane|cell-cell junction|adherens junction|protein dephosphorylation|cell adhesion|signal transduction|transforming growth factor beta receptor signaling pathway|beta-catenin binding|negative regulation of cell population proliferation|cell surface|negative regulation of keratinocyte proliferation|integral component of membrane|cell migration|protein kinase binding|cell junction|negative regulation of cell migration|leading edge membrane|protein localization to cell surface|cellular response to reactive oxygen species|cellular response to UV|peptidyl-tyrosine dephosphorylation|intracellular membrane-bounded organelle|gamma-catenin binding|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|focal adhesion assembly" PTPRM 1707.003148 1614.722346 1799.28395 1.114299281 0.156136767 0.511663782 1 12.12021995 13.27955525 5797 protein tyrosine phosphatase receptor type M "GO:0001937,GO:0004725,GO:0005001,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0005911,GO:0005912,GO:0006470,GO:0007156,GO:0007165,GO:0010596,GO:0010842,GO:0016525,GO:0030027,GO:0031175,GO:0031290,GO:0035335,GO:0042493,GO:0042802,GO:0045296,GO:0048471" negative regulation of endothelial cell proliferation|protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|cell-cell junction|adherens junction|protein dephosphorylation|homophilic cell adhesion via plasma membrane adhesion molecules|signal transduction|negative regulation of endothelial cell migration|retina layer formation|negative regulation of angiogenesis|lamellipodium|neuron projection development|retinal ganglion cell axon guidance|peptidyl-tyrosine dephosphorylation|response to drug|identical protein binding|cadherin binding|perinuclear region of cytoplasm "hsa04514,hsa04520" Cell adhesion molecules|Adherens junction PTPRN2 336.2593169 261.1438845 411.3747492 1.575280041 0.655608323 0.03111293 0.895820653 0.658077682 1.019309593 5799 protein tyrosine phosphatase receptor type N2 "GO:0005001,GO:0005788,GO:0005886,GO:0005887,GO:0006470,GO:0006629,GO:0007269,GO:0030285,GO:0030667,GO:0030672,GO:0034260,GO:0035335,GO:0035773,GO:0043195,GO:0043235,GO:0043312,GO:0101003" transmembrane receptor protein tyrosine phosphatase activity|endoplasmic reticulum lumen|plasma membrane|integral component of plasma membrane|protein dephosphorylation|lipid metabolic process|neurotransmitter secretion|integral component of synaptic vesicle membrane|secretory granule membrane|synaptic vesicle membrane|negative regulation of GTPase activity|peptidyl-tyrosine dephosphorylation|insulin secretion involved in cellular response to glucose stimulus|terminal bouton|receptor complex|neutrophil degranulation|ficolin-1-rich granule membrane hsa04940 Type I diabetes mellitus PTPRR 29.26053644 36.41448589 22.10658699 0.607082221 -0.720036171 0.333223554 1 0.478192467 0.285444332 5801 protein tyrosine phosphatase receptor type R "GO:0001701,GO:0004725,GO:0005001,GO:0005515,GO:0005615,GO:0005829,GO:0005886,GO:0006470,GO:0010633,GO:0016021,GO:0019901,GO:0030054,GO:0035335,GO:0038128,GO:0048471,GO:0070373,GO:1903385" in utero embryonic development|protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|extracellular space|cytosol|plasma membrane|protein dephosphorylation|negative regulation of epithelial cell migration|integral component of membrane|protein kinase binding|cell junction|peptidyl-tyrosine dephosphorylation|ERBB2 signaling pathway|perinuclear region of cytoplasm|negative regulation of ERK1 and ERK2 cascade|regulation of homophilic cell adhesion hsa04010 MAPK signaling pathway PTPRS 680.652632 710.6026818 650.7025822 0.915705216 -0.127044855 0.624736922 1 4.997833302 4.49995979 5802 protein tyrosine phosphatase receptor type S "GO:0004721,GO:0004725,GO:0005515,GO:0005829,GO:0005886,GO:0005887,GO:0006470,GO:0008201,GO:0010977,GO:0021510,GO:0021549,GO:0021766,GO:0021987,GO:0022038,GO:0030285,GO:0030424,GO:0030426,GO:0030517,GO:0032687,GO:0032688,GO:0034164,GO:0035335,GO:0035374,GO:0043204,GO:0043395,GO:0048671,GO:0048681,GO:0050804,GO:0061000,GO:0070062,GO:0090557,GO:0098685,GO:0098978,GO:0099056,GO:0099061,GO:0099151,GO:0099560" phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|cytosol|plasma membrane|integral component of plasma membrane|protein dephosphorylation|heparin binding|negative regulation of neuron projection development|spinal cord development|cerebellum development|hippocampus development|cerebral cortex development|corpus callosum development|integral component of synaptic vesicle membrane|axon|growth cone|negative regulation of axon extension|negative regulation of interferon-alpha production|negative regulation of interferon-beta production|negative regulation of toll-like receptor 9 signaling pathway|peptidyl-tyrosine dephosphorylation|chondroitin sulfate binding|perikaryon|heparan sulfate proteoglycan binding|negative regulation of collateral sprouting|negative regulation of axon regeneration|modulation of chemical synaptic transmission|negative regulation of dendritic spine development|extracellular exosome|establishment of endothelial intestinal barrier|Schaffer collateral - CA1 synapse|glutamatergic synapse|integral component of presynaptic membrane|integral component of postsynaptic density membrane|regulation of postsynaptic density assembly|synaptic membrane adhesion PTPRU 1034.137914 1058.100919 1010.17491 0.954705635 -0.06687212 0.788217059 1 9.832648672 9.230201594 10076 protein tyrosine phosphatase receptor type U "GO:0004725,GO:0005001,GO:0005515,GO:0005886,GO:0005887,GO:0005911,GO:0006470,GO:0007155,GO:0007185,GO:0008013,GO:0008285,GO:0030154,GO:0030336,GO:0031100,GO:0034109,GO:0034394,GO:0035335,GO:0051384,GO:0090090,GO:2000049" protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|protein binding|plasma membrane|integral component of plasma membrane|cell-cell junction|protein dephosphorylation|cell adhesion|transmembrane receptor protein tyrosine phosphatase signaling pathway|beta-catenin binding|negative regulation of cell population proliferation|cell differentiation|negative regulation of cell migration|animal organ regeneration|homotypic cell-cell adhesion|protein localization to cell surface|peptidyl-tyrosine dephosphorylation|response to glucocorticoid|negative regulation of canonical Wnt signaling pathway|positive regulation of cell-cell adhesion mediated by cadherin PTPRZ1 57.56997776 47.8590386 67.28091692 1.405814218 0.491405951 0.39616917 1 0.453990211 0.627546048 5803 protein tyrosine phosphatase receptor type Z1 "GO:0004725,GO:0005001,GO:0005178,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0006470,GO:0007417,GO:0007611,GO:0019221,GO:0031226,GO:0031641,GO:0035335,GO:0043524,GO:0048709,GO:0048714,GO:0070445" protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|integrin binding|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|protein dephosphorylation|central nervous system development|learning or memory|cytokine-mediated signaling pathway|intrinsic component of plasma membrane|regulation of myelination|peptidyl-tyrosine dephosphorylation|negative regulation of neuron apoptotic process|oligodendrocyte differentiation|positive regulation of oligodendrocyte differentiation|regulation of oligodendrocyte progenitor proliferation hsa05120 Epithelial cell signaling in Helicobacter pylori infection PTRH1 318.6609852 303.8008537 333.5211167 1.097828109 0.134652184 0.669662381 1 14.65939711 15.82419531 138428 peptidyl-tRNA hydrolase 1 homolog "GO:0003723,GO:0004045,GO:0005515" RNA binding|aminoacyl-tRNA hydrolase activity|protein binding PTRH2 524.3370702 530.6110801 518.0630603 0.976351757 -0.034527084 0.905578701 1 12.5968586 12.0931585 51651 peptidyl-tRNA hydrolase 2 "GO:0004045,GO:0005515,GO:0005739,GO:0005829,GO:0006915,GO:0010629,GO:0016020,GO:2000210,GO:2000811" aminoacyl-tRNA hydrolase activity|protein binding|mitochondrion|cytosol|apoptotic process|negative regulation of gene expression|membrane|positive regulation of anoikis|negative regulation of anoikis PTRHD1 135.3192002 108.2030438 162.4353566 1.501208754 0.586124608 0.164696714 1 5.155890695 7.610548687 391356 peptidyl-tRNA hydrolase domain containing 1 "GO:0004045,GO:0005515" aminoacyl-tRNA hydrolase activity|protein binding PTS 366.4709484 322.5283036 410.4135932 1.272488611 0.347652744 0.241552278 1 19.73938392 24.69782316 5805 6-pyruvoyltetrahydropterin synthase "GO:0003874,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0006520,GO:0006729,GO:0007417,GO:0042802,GO:0046872" 6-pyruvoyltetrahydropterin synthase activity|protein binding|cytoplasm|mitochondrion|cytosol|cellular amino acid metabolic process|tetrahydrobiopterin biosynthetic process|central nervous system development|identical protein binding|metal ion binding hsa00790 Folate biosynthesis PTTG1 3677.208928 3313.718216 4040.699639 1.219385408 0.286154187 0.228572456 1 183.0714812 219.4991625 9232 "PTTG1 regulator of sister chromatid separation, securin" "GO:0004869,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006281,GO:0006511,GO:0007283,GO:0010951,GO:0017124,GO:0031145,GO:0045143,GO:0051276,GO:0051301,GO:2000816" cysteine-type endopeptidase inhibitor activity|protein binding|nucleus|cytoplasm|cytosol|DNA repair|ubiquitin-dependent protein catabolic process|spermatogenesis|negative regulation of endopeptidase activity|SH3 domain binding|anaphase-promoting complex-dependent catabolic process|homologous chromosome segregation|chromosome organization|cell division|negative regulation of mitotic sister chromatid separation "hsa04110,hsa04114,hsa05166" Cell cycle|Oocyte meiosis|Human T-cell leukemia virus 1 infection PTTG1IP 5518.609134 5138.604166 5898.614102 1.14790202 0.198999505 0.409301257 1 105.4761 119.0501815 754 PTTG1 interacting protein "GO:0002039,GO:0003674,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006606,GO:0016020,GO:0016021,GO:0031398,GO:0043518,GO:0070062,GO:1902254,GO:1903364" "p53 binding|molecular_function|protein binding|nucleus|nucleoplasm|cytoplasm|protein import into nucleus|membrane|integral component of membrane|positive regulation of protein ubiquitination|negative regulation of DNA damage response, signal transduction by p53 class mediator|extracellular exosome|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|positive regulation of cellular protein catabolic process" PTX3 2888.991847 3286.667455 2491.316238 0.758006787 -0.399717329 0.091298763 1 93.10159313 69.39071866 5806 pentraxin 3 "GO:0001550,GO:0001849,GO:0001872,GO:0001878,GO:0005515,GO:0005576,GO:0005615,GO:0006954,GO:0008228,GO:0030198,GO:0031012,GO:0035580,GO:0042802,GO:0043312,GO:0044793,GO:0044869,GO:0044871,GO:0045087,GO:0045429,GO:0046597,GO:0046790,GO:0050766,GO:1903016,GO:1903019,GO:1904724" ovarian cumulus expansion|complement component C1q complex binding|(1->3)-beta-D-glucan binding|response to yeast|protein binding|extracellular region|extracellular space|inflammatory response|opsonization|extracellular matrix organization|extracellular matrix|specific granule lumen|identical protein binding|neutrophil degranulation|negative regulation by host of viral process|negative regulation by host of viral exo-alpha-sialidase activity|negative regulation by host of viral glycoprotein metabolic process|innate immune response|positive regulation of nitric oxide biosynthetic process|negative regulation of viral entry into host cell|virion binding|positive regulation of phagocytosis|negative regulation of exo-alpha-sialidase activity|negative regulation of glycoprotein metabolic process|tertiary granule lumen PUDP 315.064196 285.0734038 345.0549882 1.210407508 0.275492841 0.376477828 1 6.312798183 7.513195551 8226 pseudouridine 5'-phosphatase "GO:0003674,GO:0005515,GO:0005829,GO:0008150,GO:0009117,GO:0016311,GO:0016791,GO:0043097,GO:0046872,GO:1990738" molecular_function|protein binding|cytosol|biological_process|nucleotide metabolic process|dephosphorylation|phosphatase activity|pyrimidine nucleoside salvage|metal ion binding|pseudouridine 5'-phosphatase activity PUF60 2420.340113 2312.840061 2527.840164 1.092959348 0.128239741 0.588199199 1 31.91107116 34.29387573 22827 poly(U) binding splicing factor 60 "GO:0000380,GO:0000381,GO:0000398,GO:0003677,GO:0003723,GO:0005515,GO:0005654,GO:0006376,GO:0006915,GO:0030054,GO:0042802,GO:0045296" "alternative mRNA splicing, via spliceosome|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|DNA binding|RNA binding|protein binding|nucleoplasm|mRNA splice site selection|apoptotic process|cell junction|identical protein binding|cadherin binding" hsa03040 Spliceosome PUM1 2060.179616 2231.687778 1888.671454 0.84629735 -0.240763445 0.308853122 1 22.11719128 18.40450468 9698 pumilio RNA binding family member 1 "GO:0000932,GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0007283,GO:0008344,GO:0010494,GO:0010608,GO:0016441,GO:0035196,GO:0035198,GO:0043488,GO:0048863,GO:0051726,GO:0051983,GO:0060964,GO:0061157,GO:1900246,GO:2000637" P-body|RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleoplasm|cytoplasm|cytosol|spermatogenesis|adult locomotory behavior|cytoplasmic stress granule|posttranscriptional regulation of gene expression|posttranscriptional gene silencing|production of miRNAs involved in gene silencing by miRNA|miRNA binding|regulation of mRNA stability|stem cell differentiation|regulation of cell cycle|regulation of chromosome segregation|regulation of gene silencing by miRNA|mRNA destabilization|positive regulation of RIG-I signaling pathway|positive regulation of gene silencing by miRNA hsa05017 Spinocerebellar ataxia PUM2 3126.565944 3265.859178 2987.272711 0.914697343 -0.128633635 0.587599112 1 10.52938452 9.470034948 23369 pumilio RNA binding family member 2 "GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005737,GO:0005829,GO:0006417,GO:0010494,GO:0010608,GO:0031965,GO:0034063,GO:0035196,GO:0035198,GO:0043488,GO:0048471,GO:0051983,GO:0060964,GO:1900246,GO:2000637" RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|cytoplasm|cytosol|regulation of translation|cytoplasmic stress granule|posttranscriptional regulation of gene expression|nuclear membrane|stress granule assembly|production of miRNAs involved in gene silencing by miRNA|miRNA binding|regulation of mRNA stability|perinuclear region of cytoplasm|regulation of chromosome segregation|regulation of gene silencing by miRNA|positive regulation of RIG-I signaling pathway|positive regulation of gene silencing by miRNA hsa05017 Spinocerebellar ataxia PUM3 805.855157 780.310412 831.3999019 1.06547329 0.091494427 0.71951546 1 19.04148721 19.94870055 9933 pumilio RNA binding family member 3 "GO:0003677,GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0005783,GO:0006417,GO:0010835" DNA binding|RNA binding|mRNA binding|protein binding|nucleoplasm|chromosome|nucleolus|endoplasmic reticulum|regulation of translation|regulation of protein ADP-ribosylation PURA 1061.471723 1006.080225 1116.863221 1.110113482 0.150707164 0.539356025 1 4.664464641 5.091436842 5813 purine rich element binding protein A "GO:0000122,GO:0000781,GO:0000900,GO:0000977,GO:0000981,GO:0003691,GO:0003697,GO:0003723,GO:0005515,GO:0005634,GO:0006268,GO:0006270,GO:0006357,GO:0007399,GO:0008134,GO:0008284,GO:0017148,GO:0030154,GO:0032422,GO:0032839,GO:0043025,GO:0046332,GO:0046651,GO:0050673,GO:0098794,GO:0098963,GO:0098978" "negative regulation of transcription by RNA polymerase II|chromosome, telomeric region|translation repressor activity, mRNA regulatory element binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|double-stranded telomeric DNA binding|single-stranded DNA binding|RNA binding|protein binding|nucleus|DNA unwinding involved in DNA replication|DNA replication initiation|regulation of transcription by RNA polymerase II|nervous system development|transcription factor binding|positive regulation of cell population proliferation|negative regulation of translation|cell differentiation|purine-rich negative regulatory element binding|dendrite cytoplasm|neuronal cell body|SMAD binding|lymphocyte proliferation|epithelial cell proliferation|postsynapse|dendritic transport of messenger ribonucleoprotein complex|glutamatergic synapse" PURB 2259.227603 2309.718819 2208.736387 0.956279339 -0.064495989 0.786421939 1 13.35197664 12.55456054 5814 purine rich element binding protein B "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0003697,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008134,GO:0008283,GO:0030154,GO:0032422,GO:0045637,GO:0046332" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|single-stranded DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription factor binding|cell population proliferation|cell differentiation|purine-rich negative regulatory element binding|regulation of myeloid cell differentiation|SMAD binding" PURG 56.12321341 60.34400519 51.90242162 0.860108994 -0.217408603 0.727932698 1 0.94385951 0.798237312 29942 purine rich element binding protein G "GO:0000977,GO:0000981,GO:0003723,GO:0005634,GO:0006357,GO:0032422" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA binding|nucleus|regulation of transcription by RNA polymerase II|purine-rich negative regulatory element binding" PUS1 443.6200916 480.6712138 406.5689694 0.845835901 -0.241550298 0.392458411 1 10.56094658 8.783348995 80324 pseudouridine synthase 1 "GO:0000049,GO:0002153,GO:0003723,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0009982,GO:0031119,GO:0070902,GO:0106029,GO:1990481" tRNA binding|steroid receptor RNA activator RNA binding|RNA binding|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|pseudouridine synthase activity|tRNA pseudouridine synthesis|mitochondrial tRNA pseudouridine synthesis|tRNA pseudouridine synthase activity|mRNA pseudouridine synthesis PUS10 120.5797987 112.3646993 128.7948981 1.146222069 0.196886578 0.665760348 1 0.912045245 1.027912927 150962 pseudouridine synthase 10 "GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0009982,GO:0031053,GO:0031119,GO:0046872,GO:0070878,GO:0106029" protein binding|nucleus|cytoplasm|mitochondrion|pseudouridine synthase activity|primary miRNA processing|tRNA pseudouridine synthesis|metal ion binding|primary miRNA binding|tRNA pseudouridine synthase activity PUS3 243.0718485 249.6993318 236.4443652 0.946916291 -0.0786912 0.827041124 1 7.285945551 6.783732095 83480 pseudouridine synthase 3 "GO:0003723,GO:0005634,GO:0005737,GO:0005829,GO:0006400,GO:0009982,GO:0031119,GO:0106029,GO:1990481" RNA binding|nucleus|cytoplasm|cytosol|tRNA modification|pseudouridine synthase activity|tRNA pseudouridine synthesis|tRNA pseudouridine synthase activity|mRNA pseudouridine synthesis PUS7 483.9534288 568.0659799 399.8408777 0.703863445 -0.506632533 0.065632808 1 8.62247932 5.9674907 54517 pseudouridine synthase 7 "GO:0001522,GO:0003723,GO:0005634,GO:0009982,GO:0017148,GO:0019899,GO:0031119,GO:1902036,GO:1990481,GO:2000380" pseudouridine synthesis|RNA binding|nucleus|pseudouridine synthase activity|negative regulation of translation|enzyme binding|tRNA pseudouridine synthesis|regulation of hematopoietic stem cell differentiation|mRNA pseudouridine synthesis|regulation of mesoderm development PUS7L 865.5305002 870.8264198 860.2345806 0.987837026 -0.01765505 0.94855283 1 3.316994184 3.221819375 83448 pseudouridine synthase 7 like "GO:0001522,GO:0003723,GO:0005515,GO:0005634,GO:0009982" pseudouridine synthesis|RNA binding|protein binding|nucleus|pseudouridine synthase activity PUSL1 261.165235 270.5076095 251.8228605 0.930927085 -0.103259921 0.763743296 1 10.22414585 9.35866456 126789 pseudouridine synthase like 1 "GO:0003723,GO:0009982,GO:0031119,GO:0043231" RNA binding|pseudouridine synthase activity|tRNA pseudouridine synthesis|intracellular membrane-bounded organelle PVR 2024.900507 2024.645416 2025.155599 1.000251987 0.000363494 1 1 18.05071913 17.75313721 5817 PVR cell adhesion molecule "GO:0001618,GO:0002860,GO:0005515,GO:0005615,GO:0005737,GO:0005886,GO:0005912,GO:0005925,GO:0007156,GO:0007157,GO:0009986,GO:0016021,GO:0034332,GO:0038023,GO:0042271,GO:0045954,GO:0046718,GO:0050776,GO:0050839,GO:0060370" virus receptor activity|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|protein binding|extracellular space|cytoplasm|plasma membrane|adherens junction|focal adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|cell surface|integral component of membrane|adherens junction organization|signaling receptor activity|susceptibility to natural killer cell mediated cytotoxicity|positive regulation of natural killer cell mediated cytotoxicity|viral entry into host cell|regulation of immune response|cell adhesion molecule binding|susceptibility to T cell mediated cytotoxicity hsa04514 Cell adhesion molecules PWP1 2184.685754 1942.452719 2426.918789 1.249409453 0.32124635 0.174289159 1 38.78231632 47.64416394 11137 "PWP1 homolog, endonuclein" "GO:0005634,GO:0005694,GO:0005730,GO:0005794,GO:0006351,GO:0033140,GO:0034773,GO:0042254,GO:1901838,GO:1990889,GO:2000738" "nucleus|chromosome|nucleolus|Golgi apparatus|transcription, DNA-templated|negative regulation of peptidyl-serine phosphorylation of STAT protein|histone H4-K20 trimethylation|ribosome biogenesis|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|H4K20me3 modified histone binding|positive regulation of stem cell differentiation" PWP2 4.404459729 2.080827765 6.728091692 3.233372701 1.693039812 0.389066599 1 0.031281677 0.099452791 5822 PWP2 small subunit processome component "GO:0000028,GO:0000462,GO:0003723,GO:0005654,GO:0006364,GO:0032040,GO:0034388" "ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleoplasm|rRNA processing|small-subunit processome|Pwp2p-containing subcomplex of 90S preribosome" hsa03008 Ribosome biogenesis in eukaryotes PWWP2A 629.3106607 611.763363 646.8579584 1.057366291 0.08047524 0.762456675 1 3.870161962 4.023701731 114825 PWWP domain containing 2A "GO:0003682,GO:0005515,GO:0005634,GO:0042393" chromatin binding|protein binding|nucleus|histone binding PWWP2B 73.29507289 82.19269673 64.39744905 0.783493566 -0.352006668 0.510424287 1 1.825415381 1.406268726 170394 PWWP domain containing 2B "GO:0005515,GO:0005654" protein binding|nucleoplasm PWWP3A 430.466463 425.529278 435.4036481 1.023204913 0.033095097 0.915627071 1 3.126337483 3.145354884 84939 "PWWP domain containing 3A, DNA repair factor" "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006325,GO:0031491" protein binding|nucleus|nucleoplasm|cytosol|DNA repair|chromatin organization|nucleosome binding PWWP3B 138.2768956 122.7688382 153.784953 1.252638335 0.324969936 0.442388323 1 1.465104484 1.804535684 139221 PWWP domain containing 3B GO:0070062 extracellular exosome PXDC1 1016.168445 1027.928916 1004.407974 0.977118124 -0.033395115 0.895780751 1 25.26885168 24.27748831 221749 PX domain containing 1 GO:0035091 phosphatidylinositol binding PXDN 230.254759 253.8609874 206.6485305 0.814022401 -0.296859598 0.39224555 1 1.973215019 1.579362956 7837 peroxidasin "GO:0001960,GO:0004601,GO:0005152,GO:0005201,GO:0005576,GO:0005615,GO:0005783,GO:0006955,GO:0006979,GO:0019806,GO:0020037,GO:0030198,GO:0030199,GO:0042744,GO:0046872,GO:0055114,GO:0062023,GO:0070062,GO:0070831,GO:0098869" negative regulation of cytokine-mediated signaling pathway|peroxidase activity|interleukin-1 receptor antagonist activity|extracellular matrix structural constituent|extracellular region|extracellular space|endoplasmic reticulum|immune response|response to oxidative stress|bromide peroxidase activity|heme binding|extracellular matrix organization|collagen fibril organization|hydrogen peroxide catabolic process|metal ion binding|oxidation-reduction process|collagen-containing extracellular matrix|extracellular exosome|basement membrane assembly|cellular oxidant detoxification PXDNL 21.45743232 20.80827765 22.10658699 1.062393888 0.087318751 0.979502542 1 0.221745115 0.231638531 137902 peroxidasin like "GO:0004519,GO:0004601,GO:0005615,GO:0005737,GO:0006979,GO:0020037,GO:0042744,GO:0046872,GO:0055114,GO:0090305,GO:0098869" endonuclease activity|peroxidase activity|extracellular space|cytoplasm|response to oxidative stress|heme binding|hydrogen peroxide catabolic process|metal ion binding|oxidation-reduction process|nucleic acid phosphodiester bond hydrolysis|cellular oxidant detoxification PXK 764.4405481 891.6346974 637.2463988 0.714694483 -0.484601444 0.05542739 1 6.211317719 4.364910596 54899 PX domain containing serine/threonine kinase like "GO:0000166,GO:0003779,GO:0004672,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0006954,GO:0032780,GO:0032991,GO:0034451,GO:0035091,GO:0042391,GO:0043271,GO:0050804" nucleotide binding|actin binding|protein kinase activity|ATP binding|cytoplasm|cytosol|plasma membrane|protein phosphorylation|inflammatory response|negative regulation of ATPase activity|protein-containing complex|centriolar satellite|phosphatidylinositol binding|regulation of membrane potential|negative regulation of ion transport|modulation of chemical synaptic transmission PXMP2 216.6601814 199.7594655 233.5608973 1.169210664 0.225534893 0.528407543 1 10.99051086 12.63519143 5827 peroxisomal membrane protein 2 "GO:0005515,GO:0005737,GO:0005739,GO:0005778,GO:0008150,GO:0016020,GO:0016021,GO:0032991" protein binding|cytoplasm|mitochondrion|peroxisomal membrane|biological_process|membrane|integral component of membrane|protein-containing complex hsa04146 Peroxisome PXMP4 222.293139 234.0931236 210.4931544 0.899185551 -0.153309242 0.669172866 1 2.195627375 1.941239569 11264 peroxisomal membrane protein 4 "GO:0005515,GO:0005777,GO:0005778,GO:0008150,GO:0016021" protein binding|peroxisome|peroxisomal membrane|biological_process|integral component of membrane hsa04146 Peroxisome PXN 8797.509466 8227.592984 9367.425947 1.13853784 0.187182242 0.451424447 1 60.72348443 67.97908774 5829 paxillin "GO:0001725,GO:0003712,GO:0005515,GO:0005829,GO:0005875,GO:0005886,GO:0005911,GO:0005925,GO:0005938,GO:0006355,GO:0006936,GO:0007155,GO:0007160,GO:0007165,GO:0007172,GO:0007179,GO:0008013,GO:0017166,GO:0019903,GO:0030027,GO:0034446,GO:0034614,GO:0038191,GO:0043542,GO:0046872,GO:0048010,GO:0051496,GO:0060396" "stress fiber|transcription coregulator activity|protein binding|cytosol|microtubule associated complex|plasma membrane|cell-cell junction|focal adhesion|cell cortex|regulation of transcription, DNA-templated|muscle contraction|cell adhesion|cell-matrix adhesion|signal transduction|signal complex assembly|transforming growth factor beta receptor signaling pathway|beta-catenin binding|vinculin binding|protein phosphatase binding|lamellipodium|substrate adhesion-dependent cell spreading|cellular response to reactive oxygen species|neuropilin binding|endothelial cell migration|metal ion binding|vascular endothelial growth factor receptor signaling pathway|positive regulation of stress fiber assembly|growth hormone receptor signaling pathway" "hsa04062,hsa04370,hsa04510,hsa04670,hsa04810,hsa05100,hsa05131,hsa05135,hsa05163,hsa05165,hsa05170,hsa05203,hsa05205" Chemokine signaling pathway|VEGF signaling pathway|Focal adhesion|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Shigellosis|Yersinia infection|Human cytomegalovirus infection|Human papillomavirus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Proteoglycans in cancer PXYLP1 250.9045208 291.3158871 210.4931544 0.722559818 -0.468811067 0.161070492 1 3.860688721 2.74289872 92370 2-phosphoxylose phosphatase 1 "GO:0000139,GO:0005515,GO:0005794,GO:0006024,GO:0010909,GO:0016021,GO:0016311,GO:0016791,GO:0050650" Golgi membrane|protein binding|Golgi apparatus|glycosaminoglycan biosynthetic process|positive regulation of heparan sulfate proteoglycan biosynthetic process|integral component of membrane|dephosphorylation|phosphatase activity|chondroitin sulfate proteoglycan biosynthetic process PYCARD 367.3723537 371.4277561 363.3169514 0.97816317 -0.03185295 0.92397515 1 26.185491 25.18507259 29108 PYD and CARD domain containing "GO:0000139,GO:0001773,GO:0002020,GO:0002218,GO:0002230,GO:0002277,GO:0002588,GO:0002821,GO:0005138,GO:0005515,GO:0005523,GO:0005576,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0006915,GO:0006919,GO:0006954,GO:0007165,GO:0008385,GO:0008656,GO:0010506,GO:0010803,GO:0017024,GO:0019899,GO:0030838,GO:0031647,GO:0032088,GO:0032090,GO:0032688,GO:0032722,GO:0032729,GO:0032731,GO:0032733,GO:0032755,GO:0032757,GO:0032760,GO:0032991,GO:0033209,GO:0034774,GO:0035578,GO:0042104,GO:0042771,GO:0042802,GO:0042803,GO:0043025,GO:0043065,GO:0043087,GO:0043124,GO:0043280,GO:0043312,GO:0044325,GO:0044351,GO:0045087,GO:0046330,GO:0046983,GO:0050727,GO:0050766,GO:0050829,GO:0050870,GO:0051091,GO:0051092,GO:0051260,GO:0051607,GO:0070374,GO:0070700,GO:0071222,GO:0071347,GO:0071356,GO:0071901,GO:0072332,GO:0072558,GO:0072559,GO:0090200,GO:0097153,GO:0097169,GO:0097202,GO:1900016,GO:2000406,GO:2001056,GO:2001238,GO:2001242" Golgi membrane|myeloid dendritic cell activation|protease binding|activation of innate immune response|positive regulation of defense response to virus by host|myeloid dendritic cell activation involved in immune response|positive regulation of antigen processing and presentation of peptide antigen via MHC class II|positive regulation of adaptive immune response|interleukin-6 receptor binding|protein binding|tropomyosin binding|extracellular region|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|signal transduction|IkappaB kinase complex|cysteine-type endopeptidase activator activity involved in apoptotic process|regulation of autophagy|regulation of tumor necrosis factor-mediated signaling pathway|myosin I binding|enzyme binding|positive regulation of actin filament polymerization|regulation of protein stability|negative regulation of NF-kappaB transcription factor activity|Pyrin domain binding|negative regulation of interferon-beta production|positive regulation of chemokine production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-10 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|protein-containing complex|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|azurophil granule lumen|positive regulation of activated T cell proliferation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|identical protein binding|protein homodimerization activity|neuronal cell body|positive regulation of apoptotic process|regulation of GTPase activity|negative regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|neutrophil degranulation|ion channel binding|macropinocytosis|innate immune response|positive regulation of JNK cascade|protein dimerization activity|regulation of inflammatory response|positive regulation of phagocytosis|defense response to Gram-negative bacterium|positive regulation of T cell activation|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|protein homooligomerization|defense response to virus|positive regulation of ERK1 and ERK2 cascade|BMP receptor binding|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to tumor necrosis factor|negative regulation of protein serine/threonine kinase activity|intrinsic apoptotic signaling pathway by p53 class mediator|NLRP1 inflammasome complex|NLRP3 inflammasome complex|positive regulation of release of cytochrome c from mitochondria|cysteine-type endopeptidase activity involved in apoptotic process|AIM2 inflammasome complex|activation of cysteine-type endopeptidase activity|negative regulation of cytokine production involved in inflammatory response|positive regulation of T cell migration|positive regulation of cysteine-type endopeptidase activity|positive regulation of extrinsic apoptotic signaling pathway|regulation of intrinsic apoptotic signaling pathway "hsa04217,hsa04621,hsa04623,hsa04625,hsa05130,hsa05131,hsa05132,hsa05133,hsa05134,hsa05135,hsa05164" Necroptosis|NOD-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Influenza A PYCR1 1769.505395 2044.413279 1494.597512 0.731064275 -0.451929842 0.056821196 1 50.4889307 36.29300371 5831 pyrroline-5-carboxylate reductase 1 "GO:0004735,GO:0005515,GO:0005739,GO:0005759,GO:0006561,GO:0008652,GO:0034599,GO:0042802,GO:0051881,GO:0055114,GO:0055129,GO:1903206" pyrroline-5-carboxylate reductase activity|protein binding|mitochondrion|mitochondrial matrix|proline biosynthetic process|cellular amino acid biosynthetic process|cellular response to oxidative stress|identical protein binding|regulation of mitochondrial membrane potential|oxidation-reduction process|L-proline biosynthetic process|negative regulation of hydrogen peroxide-induced cell death hsa00330 Arginine and proline metabolism PYCR2 1085.059058 1108.040785 1062.077331 0.958518266 -0.061122171 0.805477809 1 35.19886917 33.17418658 29920 pyrroline-5-carboxylate reductase 2 "GO:0004735,GO:0005515,GO:0005739,GO:0005759,GO:0006561,GO:0008652,GO:0034599,GO:0055114,GO:0055129" pyrroline-5-carboxylate reductase activity|protein binding|mitochondrion|mitochondrial matrix|proline biosynthetic process|cellular amino acid biosynthetic process|cellular response to oxidative stress|oxidation-reduction process|L-proline biosynthetic process hsa00330 Arginine and proline metabolism PYCR3 240.2229792 263.2247123 217.2212461 0.825231203 -0.277129722 0.417833705 1 4.203416849 3.410745229 65263 pyrroline-5-carboxylate reductase 3 "GO:0004735,GO:0005515,GO:0005829,GO:0008652,GO:0045171,GO:0055114,GO:0055129,GO:0072686" pyrroline-5-carboxylate reductase activity|protein binding|cytosol|cellular amino acid biosynthetic process|intercellular bridge|oxidation-reduction process|L-proline biosynthetic process|mitotic spindle hsa00330 Arginine and proline metabolism PYGB 6037.987669 6346.524684 5729.450654 0.902769774 -0.147569979 0.542569796 1 82.28920262 73.04509233 5834 glycogen phosphorylase B "GO:0005515,GO:0005576,GO:0005737,GO:0005980,GO:0008184,GO:0016020,GO:0030170,GO:0035578,GO:0043312,GO:0070062,GO:0102250,GO:0102499" protein binding|extracellular region|cytoplasm|glycogen catabolic process|glycogen phosphorylase activity|membrane|pyridoxal phosphate binding|azurophil granule lumen|neutrophil degranulation|extracellular exosome|linear malto-oligosaccharide phosphorylase activity|SHG alpha-glucan phosphorylase activity "hsa00500,hsa04217,hsa04910,hsa04922,hsa04931" Starch and sucrose metabolism|Necroptosis|Insulin signaling pathway|Glucagon signaling pathway|Insulin resistance PYGL 4659.394116 4496.668801 4822.119431 1.07237594 0.100810756 0.67408208 1 85.73738813 90.4041754 5836 glycogen phosphorylase L "GO:0002060,GO:0005515,GO:0005524,GO:0005536,GO:0005576,GO:0005737,GO:0005829,GO:0005977,GO:0005980,GO:0006015,GO:0008144,GO:0008184,GO:0009617,GO:0016208,GO:0019842,GO:0030170,GO:0032052,GO:0034774,GO:0042593,GO:0042802,GO:0043312,GO:0070062,GO:0070266,GO:0102250,GO:0102499,GO:1904813" purine nucleobase binding|protein binding|ATP binding|glucose binding|extracellular region|cytoplasm|cytosol|glycogen metabolic process|glycogen catabolic process|5-phosphoribose 1-diphosphate biosynthetic process|drug binding|glycogen phosphorylase activity|response to bacterium|AMP binding|vitamin binding|pyridoxal phosphate binding|bile acid binding|secretory granule lumen|glucose homeostasis|identical protein binding|neutrophil degranulation|extracellular exosome|necroptotic process|linear malto-oligosaccharide phosphorylase activity|SHG alpha-glucan phosphorylase activity|ficolin-1-rich granule lumen "hsa00500,hsa04217,hsa04910,hsa04922,hsa04931" Starch and sucrose metabolism|Necroptosis|Insulin signaling pathway|Glucagon signaling pathway|Insulin resistance PYGO1 339.1075718 348.5386507 329.6764929 0.945882163 -0.080267629 0.799553699 1 2.060124842 1.916027569 26108 pygopus family PHD finger 1 "GO:0001822,GO:0002244,GO:0005515,GO:0005654,GO:0007289,GO:0034504,GO:0035064,GO:0045944,GO:0046872,GO:0060070,GO:1904837" kidney development|hematopoietic progenitor cell differentiation|protein binding|nucleoplasm|spermatid nucleus differentiation|protein localization to nucleus|methylated histone binding|positive regulation of transcription by RNA polymerase II|metal ion binding|canonical Wnt signaling pathway|beta-catenin-TCF complex assembly PYGO2 1052.999342 1061.22216 1044.776524 0.984503117 -0.022532322 0.930710304 1 17.80989819 17.2404942 90780 pygopus family PHD finger 2 "GO:0001822,GO:0002088,GO:0003682,GO:0005515,GO:0005654,GO:0007289,GO:0007420,GO:0030879,GO:0033599,GO:0035034,GO:0035065,GO:0035563,GO:0042393,GO:0046872,GO:0048589,GO:0051569,GO:0060021,GO:0060070,GO:1904837,GO:1990907" kidney development|lens development in camera-type eye|chromatin binding|protein binding|nucleoplasm|spermatid nucleus differentiation|brain development|mammary gland development|regulation of mammary gland epithelial cell proliferation|histone acetyltransferase regulator activity|regulation of histone acetylation|positive regulation of chromatin binding|histone binding|metal ion binding|developmental growth|regulation of histone H3-K4 methylation|roof of mouth development|canonical Wnt signaling pathway|beta-catenin-TCF complex assembly|beta-catenin-TCF complex PYM1 211.6562568 194.5573961 228.7551175 1.175771891 0.233608194 0.517186567 1 8.260278955 9.549683231 84305 "PYM homolog 1, exon junction complex associated factor" "GO:0000184,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0030054,GO:0035145,GO:0043022,GO:0045727,GO:1903259" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|cell junction|exon-exon junction complex|ribosome binding|positive regulation of translation|exon-exon junction complex disassembly" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway PYROXD1 118.647426 137.3346325 99.96021942 0.72785879 -0.458269511 0.300686894 1 1.89094348 1.35330865 79912 pyridine nucleotide-disulphide oxidoreductase domain 1 "GO:0005515,GO:0005634,GO:0016491,GO:0030017,GO:0034599,GO:0055114" protein binding|nucleus|oxidoreductase activity|sarcomere|cellular response to oxidative stress|oxidation-reduction process PYROXD2 689.2382546 771.9871009 606.4894082 0.785621168 -0.348094292 0.175217751 1 4.499239131 3.475549127 84795 pyridine nucleotide-disulphide oxidoreductase domain 2 "GO:0005515,GO:0005759,GO:0007005,GO:0016491,GO:0055114" protein binding|mitochondrial matrix|mitochondrion organization|oxidoreductase activity|oxidation-reduction process PYY 3.641448589 7.282897178 0 0 #NAME? 0.060320757 1 0.375894427 0 5697 peptide YY "GO:0001664,GO:0005179,GO:0005184,GO:0005515,GO:0005576,GO:0005615,GO:0007186,GO:0007218,GO:0007631,GO:0031841,GO:0060575" G protein-coupled receptor binding|hormone activity|neuropeptide hormone activity|protein binding|extracellular region|extracellular space|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|feeding behavior|neuropeptide Y receptor binding|intestinal epithelial cell differentiation hsa04080 Neuroactive ligand-receptor interaction QARS1 4931.761099 4796.307999 5067.2142 1.056482236 0.07926851 0.741611111 1 104.5202706 108.5760163 5859 glutaminyl-tRNA synthetase 1 "GO:0004819,GO:0004860,GO:0005515,GO:0005524,GO:0005737,GO:0005759,GO:0005829,GO:0006418,GO:0006425,GO:0006469,GO:0007420,GO:0017101,GO:0019901,GO:0032873,GO:0032991,GO:0045892,GO:2001234" "glutamine-tRNA ligase activity|protein kinase inhibitor activity|protein binding|ATP binding|cytoplasm|mitochondrial matrix|cytosol|tRNA aminoacylation for protein translation|glutaminyl-tRNA aminoacylation|negative regulation of protein kinase activity|brain development|aminoacyl-tRNA synthetase multienzyme complex|protein kinase binding|negative regulation of stress-activated MAPK cascade|protein-containing complex|negative regulation of transcription, DNA-templated|negative regulation of apoptotic signaling pathway" hsa00970 Aminoacyl-tRNA biosynthesis QDPR 751.2774731 760.5425482 742.012398 0.975635617 -0.035585669 0.893671299 1 26.9334824 25.83755027 5860 quinoid dihydropteridine reductase "GO:0001889,GO:0004155,GO:0005737,GO:0005829,GO:0006520,GO:0006559,GO:0006729,GO:0009055,GO:0010044,GO:0010288,GO:0022900,GO:0033762,GO:0035690,GO:0042802,GO:0043005,GO:0051066,GO:0070062,GO:0070402,GO:0070404" "liver development|6,7-dihydropteridine reductase activity|cytoplasm|cytosol|cellular amino acid metabolic process|L-phenylalanine catabolic process|tetrahydrobiopterin biosynthetic process|electron transfer activity|response to aluminum ion|response to lead ion|electron transport chain|response to glucagon|cellular response to drug|identical protein binding|neuron projection|dihydrobiopterin metabolic process|extracellular exosome|NADPH binding|NADH binding" hsa00790 Folate biosynthesis QKI 1837.699622 1765.582359 1909.816885 1.081692324 0.113290198 0.633836168 1 7.111924333 7.564183462 9444 "QKI, KH domain containing RNA binding" "GO:0001570,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0006397,GO:0006417,GO:0007286,GO:0008380,GO:0010628,GO:0017124,GO:0042552,GO:0042692,GO:0042759,GO:0045202,GO:0048024,GO:0051028" "vasculogenesis|RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|mRNA processing|regulation of translation|spermatid development|RNA splicing|positive regulation of gene expression|SH3 domain binding|myelination|muscle cell differentiation|long-chain fatty acid biosynthetic process|synapse|regulation of mRNA splicing, via spliceosome|mRNA transport" QPCT 141.6705095 148.7791852 134.5618338 0.904439916 -0.14490343 0.739451727 1 4.717808479 4.19557227 25797 glutaminyl-peptide cyclotransferase "GO:0005515,GO:0005576,GO:0006464,GO:0008270,GO:0016603,GO:0017186,GO:0018215,GO:0035580,GO:0043312,GO:0070062,GO:1904724,GO:1904813" "protein binding|extracellular region|cellular protein modification process|zinc ion binding|glutaminyl-peptide cyclotransferase activity|peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|protein phosphopantetheinylation|specific granule lumen|neutrophil degranulation|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen" QPCTL 278.7830739 278.8309205 278.7352272 0.999656805 -0.00049521 1 1 6.164330472 6.059098585 54814 glutaminyl-peptide cyclotransferase like "GO:0000139,GO:0005794,GO:0008270,GO:0016020,GO:0016021,GO:0016603,GO:0017186,GO:0018215" "Golgi membrane|Golgi apparatus|zinc ion binding|membrane|integral component of membrane|glutaminyl-peptide cyclotransferase activity|peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|protein phosphopantetheinylation" QPRT 2581.952707 2366.941583 2796.963832 1.181678438 0.240837498 0.308485503 1 59.41642617 69.03622181 23475 quinolinate phosphoribosyltransferase "GO:0004514,GO:0005515,GO:0005737,GO:0005829,GO:0009435,GO:0019674,GO:0034213,GO:0042802,GO:0070062,GO:1902494" nicotinate-nucleotide diphosphorylase (carboxylating) activity|protein binding|cytoplasm|cytosol|NAD biosynthetic process|NAD metabolic process|quinolinate catabolic process|identical protein binding|extracellular exosome|catalytic complex hsa00760 Nicotinate and nicotinamide metabolism QRICH1 1814.403551 1835.290089 1793.517014 0.97723898 -0.033216685 0.890820815 1 24.81531769 23.84469654 54870 glutamine rich 1 "GO:0003674,GO:0005515,GO:0005654,GO:0008150" molecular_function|protein binding|nucleoplasm|biological_process QRICH2 20.53590533 21.84869154 19.22311912 0.879829306 -0.184704438 0.882365114 1 0.124975832 0.108117411 84074 glutamine rich 2 "GO:0005515,GO:0005737,GO:0030031,GO:0030317,GO:0031965,GO:0036126,GO:2000059" protein binding|cytoplasm|cell projection assembly|flagellated sperm motility|nuclear membrane|sperm flagellum|negative regulation of ubiquitin-dependent protein catabolic process QRSL1 319.9637106 350.6194785 289.3079428 0.825133686 -0.277300214 0.370687199 1 4.59188151 3.725513738 55278 glutaminyl-tRNA amidotransferase subunit QRSL1 "GO:0005515,GO:0005524,GO:0005739,GO:0016787,GO:0030956,GO:0031647,GO:0032543,GO:0050567,GO:0070681" protein binding|ATP binding|mitochondrion|hydrolase activity|glutamyl-tRNA(Gln) amidotransferase complex|regulation of protein stability|mitochondrial translation|glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity|glutaminyl-tRNAGln biosynthesis via transamidation hsa00970 Aminoacyl-tRNA biosynthesis QSER1 2464.986133 2828.885347 2101.08692 0.742726078 -0.42909786 0.069599393 1 13.58031948 9.917674227 79832 glutamine and serine rich 1 QSOX1 5130.368138 4875.379454 5385.356821 1.1046026 0.143527428 0.550560751 1 102.1554931 110.9529782 5768 quiescin sulfhydryl oxidase 1 "GO:0000139,GO:0002576,GO:0003756,GO:0005576,GO:0005615,GO:0005788,GO:0005794,GO:0006457,GO:0016242,GO:0016971,GO:0018215,GO:0030173,GO:0031093,GO:0035580,GO:0043231,GO:0043312,GO:0043687,GO:0044267,GO:0045171,GO:0055114,GO:0070062,GO:0071949,GO:0085029,GO:1904724" Golgi membrane|platelet degranulation|protein disulfide isomerase activity|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|protein folding|negative regulation of macroautophagy|flavin-linked sulfhydryl oxidase activity|protein phosphopantetheinylation|integral component of Golgi membrane|platelet alpha granule lumen|specific granule lumen|intracellular membrane-bounded organelle|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|intercellular bridge|oxidation-reduction process|extracellular exosome|FAD binding|extracellular matrix assembly|tertiary granule lumen QSOX2 1361.889638 1461.781505 1261.99777 0.863328593 -0.212018324 0.377324813 1 17.33228 14.71305979 169714 quiescin sulfhydryl oxidase 2 "GO:0003756,GO:0005615,GO:0005654,GO:0005794,GO:0005886,GO:0006457,GO:0016971,GO:0018215,GO:0030173,GO:0031965,GO:0055114" protein disulfide isomerase activity|extracellular space|nucleoplasm|Golgi apparatus|plasma membrane|protein folding|flavin-linked sulfhydryl oxidase activity|protein phosphopantetheinylation|integral component of Golgi membrane|nuclear membrane|oxidation-reduction process QTRT1 277.5344544 296.5179566 258.5509522 0.871957149 -0.197670856 0.546453885 1 11.90716205 10.20879742 81890 queuine tRNA-ribosyltransferase catalytic subunit 1 "GO:0005634,GO:0005741,GO:0006400,GO:0008479,GO:0032991,GO:0042803,GO:0046872,GO:0046982,GO:0101030" nucleus|mitochondrial outer membrane|tRNA modification|queuine tRNA-ribosyltransferase activity|protein-containing complex|protein homodimerization activity|metal ion binding|protein heterodimerization activity|tRNA-guanine transglycosylation QTRT2 615.5764602 705.4006124 525.7523079 0.745324428 -0.42405955 0.104969199 1 9.423262632 6.905860947 79691 queuine tRNA-ribosyltransferase accessory subunit 2 "GO:0005737,GO:0005739,GO:0005741,GO:0006400,GO:0008479,GO:0032991,GO:0042803,GO:0046872,GO:0046982,GO:0101030" cytoplasm|mitochondrion|mitochondrial outer membrane|tRNA modification|queuine tRNA-ribosyltransferase activity|protein-containing complex|protein homodimerization activity|metal ion binding|protein heterodimerization activity|tRNA-guanine transglycosylation R3HCC1 434.0286537 430.7313474 437.32596 1.015310268 0.021920668 0.947091307 1 15.88620619 15.85952414 203069 R3H domain and coiled-coil containing 1 "GO:0003676,GO:0035145" nucleic acid binding|exon-exon junction complex R3HCC1L 804.6260447 848.9777282 760.2743612 0.895517439 -0.159206567 0.528645484 1 8.163672252 7.188376025 27291 R3H domain and coiled-coil containing 1 like "GO:0005515,GO:0035145" protein binding|exon-exon junction complex R3HDM1 1232.158121 1500.276819 964.0394239 0.642574365 -0.638064669 0.008373067 0.565645221 14.49701547 9.159529726 23518 R3H domain containing 1 GO:0003723 RNA binding R3HDM2 1563.067528 1620.964829 1505.170227 0.928564396 -0.106926131 0.655043138 1 15.82654843 14.45005224 22864 R3H domain containing 2 "GO:0003723,GO:0005515,GO:0005634" RNA binding|protein binding|nucleus R3HDM4 986.179496 1010.24188 962.1171119 0.952363123 -0.070416336 0.778137405 1 26.87674596 25.16810027 91300 R3H domain containing 4 "GO:0003676,GO:0005634" nucleic acid binding|nucleus RAB10 3356.371537 3242.970072 3469.773001 1.069936794 0.097525572 0.681596054 1 48.53374998 51.05909933 10890 "RAB10, member RAS oncogene family" "GO:0000139,GO:0000145,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005789,GO:0005794,GO:0005802,GO:0005829,GO:0005856,GO:0005886,GO:0005912,GO:0005925,GO:0005929,GO:0006893,GO:0006904,GO:0007409,GO:0008021,GO:0009306,GO:0016192,GO:0016197,GO:0017157,GO:0019003,GO:0019882,GO:0030659,GO:0030667,GO:0030670,GO:0030859,GO:0031489,GO:0032593,GO:0032869,GO:0043001,GO:0043312,GO:0045055,GO:0045200,GO:0048471,GO:0055037,GO:0055038,GO:0070062,GO:0070382,GO:0071782,GO:0071786,GO:0072659,GO:0090150,GO:0097051,GO:0098609,GO:0098641,GO:1903361" Golgi membrane|exocyst|GTPase activity|protein binding|GTP binding|endosome|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|cytosol|cytoskeleton|plasma membrane|adherens junction|focal adhesion|cilium|Golgi to plasma membrane transport|vesicle docking involved in exocytosis|axonogenesis|synaptic vesicle|protein secretion|vesicle-mediated transport|endosomal transport|regulation of exocytosis|GDP binding|antigen processing and presentation|cytoplasmic vesicle membrane|secretory granule membrane|phagocytic vesicle membrane|polarized epithelial cell differentiation|myosin V binding|insulin-responsive compartment|cellular response to insulin stimulus|Golgi to plasma membrane protein transport|neutrophil degranulation|regulated exocytosis|establishment of neuroblast polarity|perinuclear region of cytoplasm|recycling endosome|recycling endosome membrane|extracellular exosome|exocytic vesicle|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network organization|protein localization to plasma membrane|establishment of protein localization to membrane|establishment of protein localization to endoplasmic reticulum membrane|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|protein localization to basolateral plasma membrane "hsa04144,hsa04152" Endocytosis|AMPK signaling pathway RAB11A 3558.587882 2912.118458 4205.057307 1.443985665 0.53005642 0.025833567 0.86539048 32.22359731 45.75178915 8766 "RAB11A, member RAS oncogene family" "GO:0000922,GO:0003091,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005771,GO:0005794,GO:0005802,GO:0005813,GO:0005828,GO:0005829,GO:0006887,GO:0007080,GO:0008017,GO:0010634,GO:0010796,GO:0010971,GO:0016192,GO:0019905,GO:0030133,GO:0030424,GO:0030659,GO:0030953,GO:0031175,GO:0031410,GO:0031489,GO:0031982,GO:0032154,GO:0032402,GO:0032465,GO:0032991,GO:0034394,GO:0034451,GO:0036258,GO:0043231,GO:0043687,GO:0045335,GO:0045773,GO:0048169,GO:0048227,GO:0048471,GO:0051223,GO:0051650,GO:0055037,GO:0055038,GO:0060627,GO:0070062,GO:0072594,GO:0072659,GO:0090150,GO:0090307,GO:0097711,GO:0098685,GO:0098837,GO:0098887,GO:0098978,GO:0099003,GO:0150093,GO:1903078,GO:1990182" "spindle pole|renal water homeostasis|GTPase activity|protein binding|GTP binding|endosome|multivesicular body|Golgi apparatus|trans-Golgi network|centrosome|kinetochore microtubule|cytosol|exocytosis|mitotic metaphase plate congression|microtubule binding|positive regulation of epithelial cell migration|regulation of multivesicular body size|positive regulation of G2/M transition of mitotic cell cycle|vesicle-mediated transport|syntaxin binding|transport vesicle|axon|cytoplasmic vesicle membrane|astral microtubule organization|neuron projection development|cytoplasmic vesicle|myosin V binding|vesicle|cleavage furrow|melanosome transport|regulation of cytokinesis|protein-containing complex|protein localization to cell surface|centriolar satellite|multivesicular body assembly|intracellular membrane-bounded organelle|post-translational protein modification|phagocytic vesicle|positive regulation of axon extension|regulation of long-term neuronal synaptic plasticity|plasma membrane to endosome transport|perinuclear region of cytoplasm|regulation of protein transport|establishment of vesicle localization|recycling endosome|recycling endosome membrane|regulation of vesicle-mediated transport|extracellular exosome|establishment of protein localization to organelle|protein localization to plasma membrane|establishment of protein localization to membrane|mitotic spindle assembly|ciliary basal body-plasma membrane docking|Schaffer collateral - CA1 synapse|postsynaptic recycling endosome|neurotransmitter receptor transport, endosome to postsynaptic membrane|glutamatergic synapse|vesicle-mediated transport in synapse|amyloid-beta clearance by transcytosis|positive regulation of protein localization to plasma membrane|exosomal secretion" "hsa04144,hsa04961,hsa04962,hsa04972,hsa05164" Endocytosis|Endocrine and other factor-regulated calcium reabsorption|Vasopressin-regulated water reabsorption|Pancreatic secretion|Influenza A RAB11B 933.663747 842.7352449 1024.592249 1.215793756 0.281898515 0.25488232 1 28.28630889 33.81484235 9230 "RAB11B, member RAS oncogene family" "GO:0001881,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005829,GO:0006887,GO:0008021,GO:0019003,GO:0030670,GO:0031489,GO:0032402,GO:0033572,GO:0035773,GO:0043687,GO:0044070,GO:0045054,GO:0045055,GO:0045296,GO:0045335,GO:0055037,GO:0055038,GO:0070062,GO:0071468,GO:0090150,GO:0098993,GO:0150093,GO:1990126,GO:2000008,GO:2001135" "receptor recycling|GTPase activity|protein binding|GTP binding|endosome|cytosol|exocytosis|synaptic vesicle|GDP binding|phagocytic vesicle membrane|myosin V binding|melanosome transport|transferrin transport|insulin secretion involved in cellular response to glucose stimulus|post-translational protein modification|regulation of anion transport|constitutive secretory pathway|regulated exocytosis|cadherin binding|phagocytic vesicle|recycling endosome|recycling endosome membrane|extracellular exosome|cellular response to acidic pH|establishment of protein localization to membrane|anchored component of synaptic vesicle membrane|amyloid-beta clearance by transcytosis|retrograde transport, endosome to plasma membrane|regulation of protein localization to cell surface|regulation of endocytic recycling" "hsa04144,hsa04152,hsa04962,hsa05164" Endocytosis|AMPK signaling pathway|Vasopressin-regulated water reabsorption|Influenza A RAB11FIP1 903.7779792 966.544497 841.0114615 0.870121825 -0.20071069 0.419805171 1 6.299023491 5.389202078 80223 RAB11 family interacting protein 1 "GO:0005829,GO:0015031,GO:0030670,GO:0043231,GO:0045055,GO:0055037,GO:0070164" cytosol|protein transport|phagocytic vesicle membrane|intracellular membrane-bounded organelle|regulated exocytosis|recycling endosome|negative regulation of adiponectin secretion hsa04144 Endocytosis RAB11FIP2 475.3627758 519.1665274 431.5590242 0.83125356 -0.266639481 0.336173035 1 4.276425896 3.495309583 22841 RAB11 family interacting protein 2 "GO:0001891,GO:0003091,GO:0005515,GO:0005654,GO:0005768,GO:0006909,GO:0019901,GO:0030010,GO:0030659,GO:0035669,GO:0035773,GO:0042802,GO:0042803,GO:0042995,GO:0043231,GO:0043547,GO:0045055,GO:0055038,GO:1903078" phagocytic cup|renal water homeostasis|protein binding|nucleoplasm|endosome|phagocytosis|protein kinase binding|establishment of cell polarity|cytoplasmic vesicle membrane|TRAM-dependent toll-like receptor 4 signaling pathway|insulin secretion involved in cellular response to glucose stimulus|identical protein binding|protein homodimerization activity|cell projection|intracellular membrane-bounded organelle|positive regulation of GTPase activity|regulated exocytosis|recycling endosome membrane|positive regulation of protein localization to plasma membrane hsa04144 Endocytosis RAB11FIP3 690.2195322 722.0472346 658.3918299 0.911840387 -0.133146785 0.607103535 1 6.336841612 5.681497956 9727 RAB11 family interacting protein 3 "GO:0005509,GO:0005515,GO:0005654,GO:0005739,GO:0005768,GO:0005813,GO:0005829,GO:0007049,GO:0016192,GO:0030139,GO:0030496,GO:0031267,GO:0032154,GO:0032456,GO:0032465,GO:0034451,GO:0042803,GO:0043231,GO:0045171,GO:0051301,GO:0051959,GO:0055037,GO:0055038,GO:0061512,GO:0070164" calcium ion binding|protein binding|nucleoplasm|mitochondrion|endosome|centrosome|cytosol|cell cycle|vesicle-mediated transport|endocytic vesicle|midbody|small GTPase binding|cleavage furrow|endocytic recycling|regulation of cytokinesis|centriolar satellite|protein homodimerization activity|intracellular membrane-bounded organelle|intercellular bridge|cell division|dynein light intermediate chain binding|recycling endosome|recycling endosome membrane|protein localization to cilium|negative regulation of adiponectin secretion hsa04144 Endocytosis RAB11FIP4 41.87445076 39.53572754 44.21317398 1.118309355 0.161319333 0.83510873 1 0.241523479 0.265578243 84440 RAB11 family interacting protein 4 "GO:0003407,GO:0005509,GO:0005515,GO:0005615,GO:0005768,GO:0005813,GO:0005819,GO:0016032,GO:0030139,GO:0030496,GO:0031267,GO:0032154,GO:0032456,GO:0032465,GO:0042803,GO:0048471,GO:0055038,GO:1903452" neural retina development|calcium ion binding|protein binding|extracellular space|endosome|centrosome|spindle|viral process|endocytic vesicle|midbody|small GTPase binding|cleavage furrow|endocytic recycling|regulation of cytokinesis|protein homodimerization activity|perinuclear region of cytoplasm|recycling endosome membrane|positive regulation of G1 to G0 transition hsa04144 Endocytosis RAB11FIP5 1650.909502 1580.388688 1721.430317 1.089244899 0.123328358 0.605142354 1 13.41964036 14.37267451 26056 RAB11 family interacting protein 5 "GO:0000139,GO:0005515,GO:0005739,GO:0005741,GO:0005769,GO:0005794,GO:0030141,GO:0030658,GO:0031901,GO:0034451,GO:0035773,GO:0043015,GO:0043231,GO:0045055,GO:0045335,GO:0055037,GO:0055038,GO:0070164,GO:0071468,GO:2000008" Golgi membrane|protein binding|mitochondrion|mitochondrial outer membrane|early endosome|Golgi apparatus|secretory granule|transport vesicle membrane|early endosome membrane|centriolar satellite|insulin secretion involved in cellular response to glucose stimulus|gamma-tubulin binding|intracellular membrane-bounded organelle|regulated exocytosis|phagocytic vesicle|recycling endosome|recycling endosome membrane|negative regulation of adiponectin secretion|cellular response to acidic pH|regulation of protein localization to cell surface hsa04144 Endocytosis RAB12 1003.367061 893.7155252 1113.018597 1.245383532 0.316590107 0.197798311 1 16.06465308 19.67187012 201475 "RAB12, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005764,GO:0005765,GO:0005768,GO:0005776,GO:0005794,GO:0005829,GO:0005886,GO:0006904,GO:0006914,GO:0008021,GO:0008333,GO:0009306,GO:0017157,GO:0019003,GO:0032482,GO:0032593,GO:0032869,GO:0044257,GO:0055037,GO:0055038,GO:0072659" Golgi membrane|GTPase activity|protein binding|GTP binding|lysosome|lysosomal membrane|endosome|autophagosome|Golgi apparatus|cytosol|plasma membrane|vesicle docking involved in exocytosis|autophagy|synaptic vesicle|endosome to lysosome transport|protein secretion|regulation of exocytosis|GDP binding|Rab protein signal transduction|insulin-responsive compartment|cellular response to insulin stimulus|cellular protein catabolic process|recycling endosome|recycling endosome membrane|protein localization to plasma membrane RAB13 2514.60075 2642.651262 2386.550239 0.903089361 -0.147059345 0.534410991 1 88.58884476 78.66489056 5872 "RAB13, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0005923,GO:0006904,GO:0008021,GO:0009306,GO:0010737,GO:0016197,GO:0016328,GO:0017157,GO:0030027,GO:0030054,GO:0030139,GO:0030140,GO:0030659,GO:0030866,GO:0031175,GO:0031410,GO:0032456,GO:0032593,GO:0032869,GO:0035767,GO:0043005,GO:0043687,GO:0044795,GO:0048210,GO:0055037,GO:0055038,GO:0070062,GO:0070830,GO:0072659,GO:0097368" GTPase activity|protein binding|GTP binding|endosome|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|bicellular tight junction|vesicle docking involved in exocytosis|synaptic vesicle|protein secretion|protein kinase A signaling|endosomal transport|lateral plasma membrane|regulation of exocytosis|lamellipodium|cell junction|endocytic vesicle|trans-Golgi network transport vesicle|cytoplasmic vesicle membrane|cortical actin cytoskeleton organization|neuron projection development|cytoplasmic vesicle|endocytic recycling|insulin-responsive compartment|cellular response to insulin stimulus|endothelial cell chemotaxis|neuron projection|post-translational protein modification|trans-Golgi network to recycling endosome transport|Golgi vesicle fusion to target membrane|recycling endosome|recycling endosome membrane|extracellular exosome|bicellular tight junction assembly|protein localization to plasma membrane|establishment of Sertoli cell barrier hsa04530 Tight junction RAB14 3479.790144 3366.779324 3592.800964 1.067132894 0.093739851 0.69354336 1 43.30653764 45.44050496 51552 "RAB14, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005764,GO:0005765,GO:0005769,GO:0005770,GO:0005791,GO:0005795,GO:0005802,GO:0005829,GO:0005886,GO:0005929,GO:0006661,GO:0006886,GO:0006895,GO:0008543,GO:0012505,GO:0016192,GO:0019003,GO:0030140,GO:0031489,GO:0031901,GO:0032456,GO:0032880,GO:0042175,GO:0042742,GO:0043231,GO:0043312,GO:0045335,GO:0045995,GO:0046907,GO:0048471,GO:0055037,GO:0055038,GO:0070062,GO:0070821,GO:0090387" Golgi membrane|GTPase activity|protein binding|GTP binding|lysosome|lysosomal membrane|early endosome|late endosome|rough endoplasmic reticulum|Golgi stack|trans-Golgi network|cytosol|plasma membrane|cilium|phosphatidylinositol biosynthetic process|intracellular protein transport|Golgi to endosome transport|fibroblast growth factor receptor signaling pathway|endomembrane system|vesicle-mediated transport|GDP binding|trans-Golgi network transport vesicle|myosin V binding|early endosome membrane|endocytic recycling|regulation of protein localization|nuclear outer membrane-endoplasmic reticulum membrane network|defense response to bacterium|intracellular membrane-bounded organelle|neutrophil degranulation|phagocytic vesicle|regulation of embryonic development|intracellular transport|perinuclear region of cytoplasm|recycling endosome|recycling endosome membrane|extracellular exosome|tertiary granule membrane|phagolysosome assembly involved in apoptotic cell clearance hsa04152 AMPK signaling pathway RAB15 568.7930484 524.3685969 613.2174999 1.169439786 0.22581758 0.397124923 1 7.762715192 8.926119491 376267 "RAB15, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005768,GO:0005794,GO:0005886,GO:0005929,GO:0006904,GO:0008021,GO:0009306,GO:0010008,GO:0017157,GO:0032482,GO:0032593,GO:0032869,GO:0048471,GO:0055037,GO:0070062,GO:0072659,GO:1903307" GTPase activity|protein binding|GTP binding|cytoplasm|endosome|Golgi apparatus|plasma membrane|cilium|vesicle docking involved in exocytosis|synaptic vesicle|protein secretion|endosome membrane|regulation of exocytosis|Rab protein signal transduction|insulin-responsive compartment|cellular response to insulin stimulus|perinuclear region of cytoplasm|recycling endosome|extracellular exosome|protein localization to plasma membrane|positive regulation of regulated secretory pathway RAB17 10.5676851 12.48496659 8.650403604 0.692865579 -0.529352609 0.69159681 1 0.20203145 0.137638251 64284 "RAB17, member RAS oncogene family" "GO:0002415,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005769,GO:0005886,GO:0006886,GO:0006897,GO:0012505,GO:0016323,GO:0016324,GO:0019003,GO:0030100,GO:0030139,GO:0030425,GO:0032401,GO:0032402,GO:0032456,GO:0042470,GO:0043025,GO:0045056,GO:0046847,GO:0050773,GO:0051489,GO:0051963,GO:0055037,GO:0055038,GO:0060271,GO:0070062" immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor|GTPase activity|protein binding|GTP binding|endosome|early endosome|plasma membrane|intracellular protein transport|endocytosis|endomembrane system|basolateral plasma membrane|apical plasma membrane|GDP binding|regulation of endocytosis|endocytic vesicle|dendrite|establishment of melanosome localization|melanosome transport|endocytic recycling|melanosome|neuronal cell body|transcytosis|filopodium assembly|regulation of dendrite development|regulation of filopodium assembly|regulation of synapse assembly|recycling endosome|recycling endosome membrane|cilium assembly|extracellular exosome RAB18 1540.288478 1401.4375 1679.139455 1.198155077 0.260814648 0.274058095 1 15.10342157 17.79342514 22931 "RAB18, member RAS oncogene family" "GO:0001654,GO:0003924,GO:0005515,GO:0005525,GO:0005789,GO:0005794,GO:0005811,GO:0005829,GO:0005886,GO:0006886,GO:0007264,GO:0007420,GO:0012505,GO:0016032,GO:0016324,GO:0019003,GO:0030667,GO:0034389,GO:0043312,GO:0071782,GO:0071786" eye development|GTPase activity|protein binding|GTP binding|endoplasmic reticulum membrane|Golgi apparatus|lipid droplet|cytosol|plasma membrane|intracellular protein transport|small GTPase mediated signal transduction|brain development|endomembrane system|viral process|apical plasma membrane|GDP binding|secretory granule membrane|lipid droplet organization|neutrophil degranulation|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network organization RAB1A 3252.032624 3077.544265 3426.520983 1.113394541 0.154964914 0.51359752 1 67.0926802 73.45061008 5861 "RAB1A, member RAS oncogene family" "GO:0000045,GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005769,GO:0005783,GO:0005794,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0006897,GO:0006914,GO:0007030,GO:0012505,GO:0016192,GO:0016477,GO:0019068,GO:0030252,GO:0030658,GO:0032402,GO:0032637,GO:0034446,GO:0042470,GO:0042742,GO:0043687,GO:0045296,GO:0047496,GO:0048208,GO:0060271,GO:0070062,GO:0090110,GO:0090557,GO:1903020,GO:1904668" "autophagosome assembly|Golgi membrane|GTPase activity|protein binding|GTP binding|early endosome|endoplasmic reticulum|Golgi apparatus|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|endocytosis|autophagy|Golgi organization|endomembrane system|vesicle-mediated transport|cell migration|virion assembly|growth hormone secretion|transport vesicle membrane|melanosome transport|interleukin-8 production|substrate adhesion-dependent cell spreading|melanosome|defense response to bacterium|post-translational protein modification|cadherin binding|vesicle transport along microtubule|COPII vesicle coating|cilium assembly|extracellular exosome|COPII-coated vesicle cargo loading|establishment of endothelial intestinal barrier|positive regulation of glycoprotein metabolic process|positive regulation of ubiquitin protein ligase activity" "hsa04140,hsa05014,hsa05022,hsa05130,hsa05134" Autophagy - animal|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Legionellosis RAB1B 4716.54511 4192.867947 5240.222272 1.249794255 0.321690613 0.179310541 1 111.1050924 136.5348972 81876 "RAB1B, member RAS oncogene family" "GO:0000045,GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005789,GO:0005794,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0012505,GO:0019068,GO:0030133,GO:0033116,GO:0034045,GO:0043687,GO:0048208,GO:0048471,GO:0070062,GO:0090557,GO:1903020,GO:2000785" "autophagosome assembly|Golgi membrane|GTPase activity|protein binding|GTP binding|endoplasmic reticulum membrane|Golgi apparatus|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|endomembrane system|virion assembly|transport vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|phagophore assembly site membrane|post-translational protein modification|COPII vesicle coating|perinuclear region of cytoplasm|extracellular exosome|establishment of endothelial intestinal barrier|positive regulation of glycoprotein metabolic process|regulation of autophagosome assembly" hsa05134 Legionellosis RAB20 166.2491835 175.8299462 156.6684208 0.891022401 -0.166466392 0.679916349 1 6.226755849 5.455337687 55647 "RAB20, member RAS oncogene family" "GO:0003924,GO:0005525,GO:0005794,GO:0006886,GO:0012505,GO:0030670,GO:0043231,GO:0045335,GO:0071346,GO:0090383,GO:0090385" GTPase activity|GTP binding|Golgi apparatus|intracellular protein transport|endomembrane system|phagocytic vesicle membrane|intracellular membrane-bounded organelle|phagocytic vesicle|cellular response to interferon-gamma|phagosome acidification|phagosome-lysosome fusion RAB21 1170.017565 1067.464644 1272.570486 1.192142984 0.253557281 0.296327942 1 3.661693412 4.292215362 23011 "RAB21, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005769,GO:0005789,GO:0005802,GO:0005829,GO:0005925,GO:0006886,GO:0008089,GO:0009898,GO:0012505,GO:0012506,GO:0017157,GO:0019003,GO:0030516,GO:0030659,GO:0031901,GO:0032154,GO:0032482,GO:0032580,GO:0045202,GO:0048260,GO:0050775,GO:0050821,GO:0070062,GO:0098559,GO:1904115,GO:2000643" GTPase activity|protein binding|GTP binding|endosome|early endosome|endoplasmic reticulum membrane|trans-Golgi network|cytosol|focal adhesion|intracellular protein transport|anterograde axonal transport|cytoplasmic side of plasma membrane|endomembrane system|vesicle membrane|regulation of exocytosis|GDP binding|regulation of axon extension|cytoplasmic vesicle membrane|early endosome membrane|cleavage furrow|Rab protein signal transduction|Golgi cisterna membrane|synapse|positive regulation of receptor-mediated endocytosis|positive regulation of dendrite morphogenesis|protein stabilization|extracellular exosome|cytoplasmic side of early endosome membrane|axon cytoplasm|positive regulation of early endosome to late endosome transport RAB22A 2120.33235 2031.928313 2208.736387 1.087014917 0.120371739 0.611693046 1 12.53499937 13.39772314 57403 "RAB22A, member RAS oncogene family" "GO:0001726,GO:0003924,GO:0005515,GO:0005525,GO:0005769,GO:0005770,GO:0005886,GO:0006886,GO:0006897,GO:0007032,GO:0010008,GO:0012505,GO:0015629,GO:0019003,GO:0030670,GO:0045335,GO:0070062,GO:0097494" ruffle|GTPase activity|protein binding|GTP binding|early endosome|late endosome|plasma membrane|intracellular protein transport|endocytosis|endosome organization|endosome membrane|endomembrane system|actin cytoskeleton|GDP binding|phagocytic vesicle membrane|phagocytic vesicle|extracellular exosome|regulation of vesicle size hsa04144 Endocytosis RAB23 798.2847962 783.4316536 813.1379388 1.037918158 0.053692689 0.835628582 1 8.405771505 8.578510136 51715 "RAB23, member RAS oncogene family" "GO:0000045,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005776,GO:0005813,GO:0005829,GO:0005886,GO:0006886,GO:0006968,GO:0010008,GO:0012505,GO:0030054,GO:0030670,GO:0042308,GO:0045335,GO:0046039,GO:0060271,GO:0097094" autophagosome assembly|GTPase activity|protein binding|GTP binding|cytoplasm|autophagosome|centrosome|cytosol|plasma membrane|intracellular protein transport|cellular defense response|endosome membrane|endomembrane system|cell junction|phagocytic vesicle membrane|negative regulation of protein import into nucleus|phagocytic vesicle|GTP metabolic process|cilium assembly|craniofacial suture morphogenesis RAB24 537.1440989 551.4193578 522.8688401 0.948223585 -0.076700818 0.78123972 1 18.53163581 17.27808826 53917 "RAB24, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005776,GO:0005829,GO:0005886,GO:0006886,GO:0006914,GO:0012505,GO:0030139,GO:0030667,GO:0043312" GTPase activity|protein binding|GTP binding|endosome|autophagosome|cytosol|plasma membrane|intracellular protein transport|autophagy|endomembrane system|endocytic vesicle|secretory granule membrane|neutrophil degranulation RAB26 75.53441651 90.51600779 60.55282523 0.668973662 -0.579978682 0.263548144 1 1.54829262 1.018434827 25837 "RAB26, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005794,GO:0017157,GO:0019002,GO:0030667,GO:0031226,GO:0035272,GO:0043001,GO:0045055,GO:0098993,GO:0099575" "Golgi membrane|GTPase activity|protein binding|GTP binding|endosome|Golgi apparatus|regulation of exocytosis|GMP binding|secretory granule membrane|intrinsic component of plasma membrane|exocrine system development|Golgi to plasma membrane protein transport|regulated exocytosis|anchored component of synaptic vesicle membrane|regulation of protein catabolic process at presynapse, modulating synaptic transmission" RAB27A 487.8087278 442.1759001 533.4415556 1.206401243 0.27070982 0.325979159 1 6.030696423 7.153695032 5873 "RAB27A, member RAS oncogene family" "GO:0001750,GO:0003924,GO:0005515,GO:0005525,GO:0005576,GO:0005764,GO:0005770,GO:0005794,GO:0005829,GO:0006605,GO:0006887,GO:0007596,GO:0010628,GO:0016324,GO:0019003,GO:0019882,GO:0019904,GO:0030141,GO:0030318,GO:0030425,GO:0030667,GO:0031489,GO:0032400,GO:0032402,GO:0032585,GO:0033093,GO:0033162,GO:0035580,GO:0036257,GO:0042470,GO:0043312,GO:0043316,GO:0043320,GO:0045921,GO:0048489,GO:0050766,GO:0070062,GO:0070382,GO:0071985,GO:0097278,GO:1903307,GO:1903428,GO:1903435,GO:1990182" photoreceptor outer segment|GTPase activity|protein binding|GTP binding|extracellular region|lysosome|late endosome|Golgi apparatus|cytosol|protein targeting|exocytosis|blood coagulation|positive regulation of gene expression|apical plasma membrane|GDP binding|antigen processing and presentation|protein domain specific binding|secretory granule|melanocyte differentiation|dendrite|secretory granule membrane|myosin V binding|melanosome localization|melanosome transport|multivesicular body membrane|Weibel-Palade body|melanosome membrane|specific granule lumen|multivesicular body organization|melanosome|neutrophil degranulation|cytotoxic T cell degranulation|natural killer cell degranulation|positive regulation of exocytosis|synaptic vesicle transport|positive regulation of phagocytosis|extracellular exosome|exocytic vesicle|multivesicular body sorting pathway|complement-dependent cytotoxicity|positive regulation of regulated secretory pathway|positive regulation of reactive oxygen species biosynthetic process|positive regulation of constitutive secretory pathway|exosomal secretion RAB27B 714.7636076 735.572615 693.9546002 0.94342093 -0.084026488 0.746380893 1 3.863795132 3.584187957 5874 "RAB27B, member RAS oncogene family" "GO:0002576,GO:0003924,GO:0005515,GO:0005525,GO:0005770,GO:0005795,GO:0005886,GO:0016324,GO:0019003,GO:0019904,GO:0030140,GO:0030141,GO:0031088,GO:0031489,GO:0032402,GO:0032585,GO:0042470,GO:0042589,GO:0045921,GO:0048488,GO:0070062,GO:0071985,GO:0098993,GO:0099641,GO:1904115" platelet degranulation|GTPase activity|protein binding|GTP binding|late endosome|Golgi stack|plasma membrane|apical plasma membrane|GDP binding|protein domain specific binding|trans-Golgi network transport vesicle|secretory granule|platelet dense granule membrane|myosin V binding|melanosome transport|multivesicular body membrane|melanosome|zymogen granule membrane|positive regulation of exocytosis|synaptic vesicle endocytosis|extracellular exosome|multivesicular body sorting pathway|anchored component of synaptic vesicle membrane|anterograde axonal protein transport|axon cytoplasm hsa04972 Pancreatic secretion RAB28 558.9537759 493.1561804 624.7513714 1.26684283 0.341237549 0.201018761 1 14.16514476 17.64472661 9364 "RAB28, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005886,GO:0006886,GO:0012505,GO:0019003,GO:0035253,GO:0036064,GO:1901998" GTPase activity|protein binding|GTP binding|cytoplasm|plasma membrane|intracellular protein transport|endomembrane system|GDP binding|ciliary rootlet|ciliary basal body|toxin transport RAB29 1448.725182 1533.570063 1363.880302 0.889349847 -0.169177045 0.479992457 1 24.82372329 21.70754625 8934 "RAB29, member RAS oncogene family" "GO:0001921,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005739,GO:0005769,GO:0005773,GO:0005794,GO:0005801,GO:0005802,GO:0005829,GO:0005856,GO:0005886,GO:0006886,GO:0006888,GO:0007005,GO:0007030,GO:0007416,GO:0009617,GO:0010977,GO:0012505,GO:0019003,GO:0019894,GO:0020003,GO:0030154,GO:0031267,GO:0032438,GO:0039694,GO:0042110,GO:0042147,GO:0042470,GO:0043231,GO:0048471,GO:0050862,GO:0055037,GO:0070062,GO:0070840,GO:0072657,GO:0090316,GO:0097708,GO:1901214,GO:1901998,GO:1903441,GO:1905279" "positive regulation of receptor recycling|GTPase activity|protein binding|GTP binding|cytoplasm|mitochondrion|early endosome|vacuole|Golgi apparatus|cis-Golgi network|trans-Golgi network|cytosol|cytoskeleton|plasma membrane|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|mitochondrion organization|Golgi organization|synapse assembly|response to bacterium|negative regulation of neuron projection development|endomembrane system|GDP binding|kinesin binding|symbiont-containing vacuole|cell differentiation|small GTPase binding|melanosome organization|viral RNA genome replication|T cell activation|retrograde transport, endosome to Golgi|melanosome|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|positive regulation of T cell receptor signaling pathway|recycling endosome|extracellular exosome|dynein complex binding|protein localization to membrane|positive regulation of intracellular protein transport|intracellular vesicle|regulation of neuron death|toxin transport|protein localization to ciliary membrane|regulation of retrograde transport, endosome to Golgi" RAB2A 3743.592855 3353.253944 4133.931767 1.23281202 0.301952833 0.204111589 1 46.94569779 56.90675706 5862 "RAB2A, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005765,GO:0005789,GO:0005794,GO:0005829,GO:0006888,GO:0007030,GO:0015031,GO:0019003,GO:0033116,GO:0042470,GO:0043687,GO:0070062" Golgi membrane|GTPase activity|protein binding|GTP binding|nucleus|lysosomal membrane|endoplasmic reticulum membrane|Golgi apparatus|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|protein transport|GDP binding|endoplasmic reticulum-Golgi intermediate compartment membrane|melanosome|post-translational protein modification|extracellular exosome hsa04152 AMPK signaling pathway RAB2B 615.770189 622.1675018 609.3728761 0.9794354 -0.029977754 0.915210044 1 10.9044125 10.50144948 84932 "RAB2B, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005789,GO:0005794,GO:0005886,GO:0015031,GO:0016192,GO:0045921,GO:0070062,GO:0098793" Golgi membrane|GTPase activity|protein binding|GTP binding|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|protein transport|vesicle-mediated transport|positive regulation of exocytosis|extracellular exosome|presynapse RAB30 226.8460537 265.3055401 188.3865674 0.710074005 -0.493958703 0.154174987 1 1.40284049 0.979451836 27314 "RAB30, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005795,GO:0005801,GO:0005802,GO:0007030,GO:0031985,GO:0032482,GO:0043231" Golgi membrane|GTPase activity|protein binding|GTP binding|Golgi stack|cis-Golgi network|trans-Golgi network|Golgi organization|Golgi cisterna|Rab protein signal transduction|intracellular membrane-bounded organelle RAB31 1435.853373 1574.146204 1297.560541 0.824294806 -0.27876769 0.243865864 1 20.27740521 16.43486427 11031 "RAB31, member RAS oncogene family" "GO:0001891,GO:0003924,GO:0005515,GO:0005525,GO:0005769,GO:0005829,GO:0005886,GO:0006886,GO:0012505,GO:0019003,GO:0030667,GO:0031623,GO:0031901,GO:0032588,GO:0032869,GO:0036186,GO:0043001,GO:0043312,GO:0045055,GO:0045335,GO:0060100,GO:0090382" "phagocytic cup|GTPase activity|protein binding|GTP binding|early endosome|cytosol|plasma membrane|intracellular protein transport|endomembrane system|GDP binding|secretory granule membrane|receptor internalization|early endosome membrane|trans-Golgi network membrane|cellular response to insulin stimulus|early phagosome membrane|Golgi to plasma membrane protein transport|neutrophil degranulation|regulated exocytosis|phagocytic vesicle|positive regulation of phagocytosis, engulfment|phagosome maturation" hsa04144 Endocytosis RAB32 640.3790454 574.3084632 706.4496277 1.230087441 0.298760873 0.250826286 1 28.77914286 34.8084767 10981 "RAB32, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005739,GO:0005741,GO:0005769,GO:0005783,GO:0005802,GO:0005829,GO:0006886,GO:0007005,GO:0012505,GO:0016020,GO:0016192,GO:0019882,GO:0030670,GO:0030742,GO:0031905,GO:0032438,GO:0033162,GO:0035612,GO:0035646,GO:0035650,GO:0035651,GO:0036461,GO:0042470,GO:0044233,GO:0045335,GO:0072657,GO:0090382,GO:1903232" GTPase activity|protein binding|GTP binding|mitochondrion|mitochondrial outer membrane|early endosome|endoplasmic reticulum|trans-Golgi network|cytosol|intracellular protein transport|mitochondrion organization|endomembrane system|membrane|vesicle-mediated transport|antigen processing and presentation|phagocytic vesicle membrane|GTP-dependent protein binding|early endosome lumen|melanosome organization|melanosome membrane|AP-2 adaptor complex binding|endosome to melanosome transport|AP-1 adaptor complex binding|AP-3 adaptor complex binding|BLOC-2 complex binding|melanosome|mitochondria-associated endoplasmic reticulum membrane|phagocytic vesicle|protein localization to membrane|phagosome maturation|melanosome assembly RAB33A 11.60809898 14.56579436 8.650403604 0.593884782 -0.751745031 0.514922909 1 0.672447815 0.392673833 9363 "RAB33A, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005794,GO:0005886,GO:0019882,GO:0032482" Golgi membrane|GTPase activity|protein binding|GTP binding|endosome|Golgi apparatus|plasma membrane|antigen processing and presentation|Rab protein signal transduction RAB33B 218.899525 208.0827765 229.7162735 1.103965822 0.142695508 0.693819676 1 2.355747845 2.557146499 83452 "RAB33B, member RAS oncogene family" "GO:0000139,GO:0001558,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005794,GO:0005796,GO:0006891,GO:0006914,GO:0015031,GO:0032482,GO:0034067,GO:0048705,GO:0050678,GO:1903358,GO:1903434,GO:2000156" "Golgi membrane|regulation of cell growth|GTPase activity|protein binding|GTP binding|endosome|Golgi apparatus|Golgi lumen|intra-Golgi vesicle-mediated transport|autophagy|protein transport|Rab protein signal transduction|protein localization to Golgi apparatus|skeletal system morphogenesis|regulation of epithelial cell proliferation|regulation of Golgi organization|negative regulation of constitutive secretory pathway|regulation of retrograde vesicle-mediated transport, Golgi to ER" hsa04140 Autophagy - animal RAB34 2109.457079 2087.070249 2131.84391 1.021452877 0.03062265 0.898948606 1 72.32669045 72.64205266 83871 "RAB34, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005794,GO:0005795,GO:0005929,GO:0006897,GO:0019882,GO:0030030,GO:0030670,GO:0030742,GO:0031267,GO:0031982,GO:0031985,GO:0032418,GO:0032587,GO:0043001,GO:0044351,GO:0045335,GO:0045880,GO:0048471,GO:0070062,GO:0072659,GO:0090382,GO:0090385" GTPase activity|protein binding|GTP binding|Golgi apparatus|Golgi stack|cilium|endocytosis|antigen processing and presentation|cell projection organization|phagocytic vesicle membrane|GTP-dependent protein binding|small GTPase binding|vesicle|Golgi cisterna|lysosome localization|ruffle membrane|Golgi to plasma membrane protein transport|macropinocytosis|phagocytic vesicle|positive regulation of smoothened signaling pathway|perinuclear region of cytoplasm|extracellular exosome|protein localization to plasma membrane|phagosome maturation|phagosome-lysosome fusion RAB35 1434.228585 1531.489235 1336.967935 0.872985525 -0.195970361 0.413189006 1 28.57789011 24.53061201 11021 "RAB35, member RAS oncogene family" "GO:0000281,GO:0003924,GO:0005515,GO:0005525,GO:0005546,GO:0005829,GO:0005886,GO:0005905,GO:0008104,GO:0010008,GO:0015031,GO:0016197,GO:0019003,GO:0019882,GO:0030665,GO:0031175,GO:0031253,GO:0032456,GO:0032482,GO:0036010,GO:0042470,GO:0045171,GO:0045334,GO:0048227,GO:0055038,GO:0070062,GO:0098993,GO:1990090" "mitotic cytokinesis|GTPase activity|protein binding|GTP binding|phosphatidylinositol-4,5-bisphosphate binding|cytosol|plasma membrane|clathrin-coated pit|protein localization|endosome membrane|protein transport|endosomal transport|GDP binding|antigen processing and presentation|clathrin-coated vesicle membrane|neuron projection development|cell projection membrane|endocytic recycling|Rab protein signal transduction|protein localization to endosome|melanosome|intercellular bridge|clathrin-coated endocytic vesicle|plasma membrane to endosome transport|recycling endosome membrane|extracellular exosome|anchored component of synaptic vesicle membrane|cellular response to nerve growth factor stimulus" hsa04144 Endocytosis RAB36 163.4053446 176.87036 149.9403291 0.847741414 -0.238303827 0.551198442 1 1.492606901 1.244170855 9609 "RAB36, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005794,GO:0015031" Golgi membrane|GTPase activity|protein binding|GTP binding|Golgi apparatus|protein transport RAB37 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.044754146 0.067754933 326624 "RAB37, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005793,GO:0005794,GO:0005886,GO:0015031,GO:0035577,GO:0035579,GO:0043312" GTPase activity|protein binding|GTP binding|endosome|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|plasma membrane|protein transport|azurophil granule membrane|specific granule membrane|neutrophil degranulation RAB38 593.6887541 559.7426689 627.6348393 1.121291755 0.165161709 0.533645766 1 7.170532279 7.905715879 23682 "RAB38, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005739,GO:0005764,GO:0005769,GO:0005783,GO:0005802,GO:0005829,GO:0005886,GO:0006886,GO:0007005,GO:0007264,GO:0012505,GO:0015031,GO:0016020,GO:0016192,GO:0030670,GO:0030742,GO:0031905,GO:0032438,GO:0033162,GO:0035612,GO:0035646,GO:0035650,GO:0035651,GO:0036461,GO:0042470,GO:0043687,GO:0044233,GO:0045335,GO:0060155,GO:0072657,GO:0090383,GO:1903232,GO:2001247" GTPase activity|protein binding|GTP binding|mitochondrion|lysosome|early endosome|endoplasmic reticulum|trans-Golgi network|cytosol|plasma membrane|intracellular protein transport|mitochondrion organization|small GTPase mediated signal transduction|endomembrane system|protein transport|membrane|vesicle-mediated transport|phagocytic vesicle membrane|GTP-dependent protein binding|early endosome lumen|melanosome organization|melanosome membrane|AP-2 adaptor complex binding|endosome to melanosome transport|AP-1 adaptor complex binding|AP-3 adaptor complex binding|BLOC-2 complex binding|melanosome|post-translational protein modification|mitochondria-associated endoplasmic reticulum membrane|phagocytic vesicle|platelet dense granule organization|protein localization to membrane|phagosome acidification|melanosome assembly|positive regulation of phosphatidylcholine biosynthetic process RAB39B 290.7679552 252.8205735 328.7153369 1.300192197 0.378724901 0.234104695 1 3.953287238 5.054021725 116442 "RAB39B, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005794,GO:0005886,GO:0006914,GO:0010506,GO:0015031,GO:0016192,GO:0030659,GO:0031489,GO:0031982,GO:0032482,GO:0043005,GO:0050808" Golgi membrane|GTPase activity|protein binding|GTP binding|Golgi apparatus|plasma membrane|autophagy|regulation of autophagy|protein transport|vesicle-mediated transport|cytoplasmic vesicle membrane|myosin V binding|vesicle|Rab protein signal transduction|neuron projection|synapse organization "hsa04140,hsa05014,hsa05022" Autophagy - animal|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases RAB3A 79.4683591 67.62690237 91.30981582 1.350199589 0.433172685 0.399832205 1 2.171554444 2.882968336 5864 "RAB3A, member RAS oncogene family" "GO:0001669,GO:0001671,GO:0001778,GO:0003016,GO:0003924,GO:0005515,GO:0005525,GO:0005764,GO:0005768,GO:0005829,GO:0005886,GO:0006887,GO:0006904,GO:0007005,GO:0007269,GO:0007274,GO:0007409,GO:0008021,GO:0008022,GO:0009306,GO:0009791,GO:0010807,GO:0014047,GO:0014059,GO:0016079,GO:0016188,GO:0017157,GO:0030324,GO:0030424,GO:0030667,GO:0030742,GO:0031489,GO:0031630,GO:0032418,GO:0032781,GO:0032991,GO:0036465,GO:0043195,GO:0043312,GO:0043687,GO:0045054,GO:0045055,GO:0045921,GO:0048172,GO:0048471,GO:0048489,GO:0048786,GO:0048790,GO:0050975,GO:0051021,GO:0051117,GO:0051602,GO:0060201,GO:0060203,GO:0060478,GO:0061202,GO:0061670,GO:0070083,GO:0072659,GO:0097091,GO:0098993,GO:1903307,GO:1903561,GO:1905684,GO:2000300" acrosomal vesicle|ATPase activator activity|plasma membrane repair|respiratory system process|GTPase activity|protein binding|GTP binding|lysosome|endosome|cytosol|plasma membrane|exocytosis|vesicle docking involved in exocytosis|mitochondrion organization|neurotransmitter secretion|neuromuscular synaptic transmission|axonogenesis|synaptic vesicle|protein C-terminus binding|protein secretion|post-embryonic development|regulation of synaptic vesicle priming|glutamate secretion|regulation of dopamine secretion|synaptic vesicle exocytosis|synaptic vesicle maturation|regulation of exocytosis|lung development|axon|secretory granule membrane|GTP-dependent protein binding|myosin V binding|regulation of synaptic vesicle fusion to presynaptic active zone membrane|lysosome localization|positive regulation of ATPase activity|protein-containing complex|synaptic vesicle recycling|terminal bouton|neutrophil degranulation|post-translational protein modification|constitutive secretory pathway|regulated exocytosis|positive regulation of exocytosis|regulation of short-term neuronal synaptic plasticity|perinuclear region of cytoplasm|synaptic vesicle transport|presynaptic active zone|maintenance of presynaptic active zone structure|sensory perception of touch|GDP-dissociation inhibitor binding|ATPase binding|response to electrical stimulus|clathrin-sculpted acetylcholine transport vesicle membrane|clathrin-sculpted glutamate transport vesicle membrane|acrosomal vesicle exocytosis|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|evoked neurotransmitter secretion|clathrin-sculpted monoamine transport vesicle membrane|protein localization to plasma membrane|synaptic vesicle clustering|anchored component of synaptic vesicle membrane|positive regulation of regulated secretory pathway|extracellular vesicle|regulation of plasma membrane repair|regulation of synaptic vesicle exocytosis "hsa04721,hsa04911" Synaptic vesicle cycle|Insulin secretion RAB3B 3987.570525 3740.287908 4234.853142 1.132226515 0.179162614 0.452003418 1 15.18888231 16.9094825 5865 "RAB3B, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005768,GO:0005794,GO:0005829,GO:0005886,GO:0006904,GO:0008021,GO:0009306,GO:0017157,GO:0019003,GO:0019882,GO:0031489,GO:0031982,GO:0048471,GO:0051586,GO:0070062,GO:0072659,GO:0097494,GO:0098691,GO:0098693,GO:0098993" GTPase activity|protein binding|GTP binding|cytoplasm|endosome|Golgi apparatus|cytosol|plasma membrane|vesicle docking involved in exocytosis|synaptic vesicle|protein secretion|regulation of exocytosis|GDP binding|antigen processing and presentation|myosin V binding|vesicle|perinuclear region of cytoplasm|positive regulation of dopamine uptake involved in synaptic transmission|extracellular exosome|protein localization to plasma membrane|regulation of vesicle size|dopaminergic synapse|regulation of synaptic vesicle cycle|anchored component of synaptic vesicle membrane RAB3D 778.0067863 717.885579 838.1279936 1.167495236 0.223416663 0.377359667 1 9.03590423 10.37284564 9545 "RAB3D, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005881,GO:0005886,GO:0006904,GO:0008021,GO:0009306,GO:0017157,GO:0018125,GO:0030742,GO:0031489,GO:0035577,GO:0042588,GO:0043312,GO:0045453,GO:0070062,GO:0072659,GO:0099503,GO:1903307" GTPase activity|protein binding|GTP binding|endosome|cytoplasmic microtubule|plasma membrane|vesicle docking involved in exocytosis|synaptic vesicle|protein secretion|regulation of exocytosis|peptidyl-cysteine methylation|GTP-dependent protein binding|myosin V binding|azurophil granule membrane|zymogen granule|neutrophil degranulation|bone resorption|extracellular exosome|protein localization to plasma membrane|secretory vesicle|positive regulation of regulated secretory pathway hsa04972 Pancreatic secretion RAB3GAP1 2330.304068 2232.728192 2427.879945 1.087405065 0.120889453 0.609893249 1 22.96773324 24.55730281 22930 RAB3 GTPase activating protein catalytic subunit 1 "GO:0005085,GO:0005096,GO:0005515,GO:0005789,GO:0005794,GO:0005811,GO:0005829,GO:0007420,GO:0021854,GO:0031267,GO:0032991,GO:0034389,GO:0043010,GO:0043087,GO:0043547,GO:0048172,GO:0060079,GO:0060325,GO:0061646,GO:0070062,GO:0071782,GO:0097051,GO:0098794,GO:1903061,GO:1903233,GO:1903373,GO:2000786" guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|endoplasmic reticulum membrane|Golgi apparatus|lipid droplet|cytosol|brain development|hypothalamus development|small GTPase binding|protein-containing complex|lipid droplet organization|camera-type eye development|regulation of GTPase activity|positive regulation of GTPase activity|regulation of short-term neuronal synaptic plasticity|excitatory postsynaptic potential|face morphogenesis|positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization|extracellular exosome|endoplasmic reticulum tubular network|establishment of protein localization to endoplasmic reticulum membrane|postsynapse|positive regulation of protein lipidation|regulation of calcium ion-dependent exocytosis of neurotransmitter|positive regulation of endoplasmic reticulum tubular network organization|positive regulation of autophagosome assembly RAB3GAP2 1623.818498 1626.166899 1621.470098 0.997111735 -0.004172915 0.988938906 1 11.96052076 11.72641055 25782 RAB3 GTPase activating non-catalytic protein subunit 2 "GO:0005085,GO:0005096,GO:0005515,GO:0005789,GO:0005829,GO:0005886,GO:0006886,GO:0008047,GO:0030234,GO:0031267,GO:0032991,GO:0043087,GO:0043547,GO:0097051,GO:1903061,GO:1903373,GO:2000786" guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|endoplasmic reticulum membrane|cytosol|plasma membrane|intracellular protein transport|enzyme activator activity|enzyme regulator activity|small GTPase binding|protein-containing complex|regulation of GTPase activity|positive regulation of GTPase activity|establishment of protein localization to endoplasmic reticulum membrane|positive regulation of protein lipidation|positive regulation of endoplasmic reticulum tubular network organization|positive regulation of autophagosome assembly RAB3IL1 199.3839119 238.2547791 160.5130447 0.673703358 -0.569814606 0.117099494 1 3.362035872 2.227112899 5866 RAB3A interacting protein like 1 "GO:0005085,GO:0005515,GO:0005829,GO:0006887,GO:0015031,GO:0042802,GO:0050790,GO:0070319" guanyl-nucleotide exchange factor activity|protein binding|cytosol|exocytosis|protein transport|identical protein binding|regulation of catalytic activity|Golgi to plasma membrane transport vesicle RAB3IP 685.3099568 681.4710931 689.1488204 1.011266402 0.016163102 0.956082044 1 3.393250583 3.374059133 117177 RAB3A interacting protein "GO:0005085,GO:0005515,GO:0005634,GO:0005829,GO:0005856,GO:0006612,GO:0006887,GO:0030027,GO:0050790,GO:0070319,GO:0097711" guanyl-nucleotide exchange factor activity|protein binding|nucleus|cytosol|cytoskeleton|protein targeting to membrane|exocytosis|lamellipodium|regulation of catalytic activity|Golgi to plasma membrane transport vesicle|ciliary basal body-plasma membrane docking RAB40A 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.084598746 0.025615425 142684 "RAB40A, member RAS oncogene family" "GO:0003924,GO:0005525,GO:0005768,GO:0005886,GO:0008021,GO:0016567,GO:0035556,GO:0072659" GTPase activity|GTP binding|endosome|plasma membrane|synaptic vesicle|protein ubiquitination|intracellular signal transduction|protein localization to plasma membrane RAB40AL 4.082397604 6.242483296 1.922311912 0.307940257 -1.699277611 0.406294648 1 0.323760797 0.098030656 282808 RAB40A like "GO:0003924,GO:0005525,GO:0005737,GO:0005739,GO:0005768,GO:0005886,GO:0008021,GO:0016567,GO:0035556,GO:0072659" GTPase activity|GTP binding|cytoplasm|mitochondrion|endosome|plasma membrane|synaptic vesicle|protein ubiquitination|intracellular signal transduction|protein localization to plasma membrane RAB40B 210.2195533 182.0724295 238.3666771 1.309186008 0.388670089 0.277499248 1 1.958256938 2.520822158 10966 "RAB40B, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005635,GO:0005768,GO:0005886,GO:0008021,GO:0016567,GO:0035556,GO:0048471,GO:0072659,GO:1901998" GTPase activity|protein binding|GTP binding|nuclear envelope|endosome|plasma membrane|synaptic vesicle|protein ubiquitination|intracellular signal transduction|perinuclear region of cytoplasm|protein localization to plasma membrane|toxin transport RAB40C 350.0419784 345.417409 354.6665478 1.026776701 0.038122465 0.908809124 1 6.465903988 6.527944231 57799 "RAB40C, member RAS oncogene family" "GO:0003924,GO:0005525,GO:0005768,GO:0005886,GO:0008021,GO:0016567,GO:0019003,GO:0035556,GO:0048471,GO:0072659" GTPase activity|GTP binding|endosome|plasma membrane|synaptic vesicle|protein ubiquitination|GDP binding|intracellular signal transduction|perinuclear region of cytoplasm|protein localization to plasma membrane RAB42 135.7003986 156.0620824 115.3387147 0.739056617 -0.436243205 0.301762965 1 3.39948837 2.470372524 115273 "RAB42, member RAS oncogene family" "GO:0003924,GO:0005525,GO:0005886,GO:0007265,GO:0019003" GTPase activity|GTP binding|plasma membrane|Ras protein signal transduction|GDP binding RAB43 33.82351202 42.65696919 24.99005486 0.585837563 -0.771427396 0.26992038 1 0.486540724 0.280264176 339122 "RAB43, member RAS oncogene family" "GO:0000045,GO:0003924,GO:0005515,GO:0005525,GO:0005794,GO:0006886,GO:0007030,GO:0012505,GO:0019068,GO:0030670,GO:0032588,GO:0035526,GO:0045335,GO:0070062,GO:0071346,GO:0090382,GO:1901998" "autophagosome assembly|GTPase activity|protein binding|GTP binding|Golgi apparatus|intracellular protein transport|Golgi organization|endomembrane system|virion assembly|phagocytic vesicle membrane|trans-Golgi network membrane|retrograde transport, plasma membrane to Golgi|phagocytic vesicle|extracellular exosome|cellular response to interferon-gamma|phagosome maturation|toxin transport" RAB4A 291.8970735 332.9324424 250.8617045 0.753491317 -0.408337208 0.198303009 1 5.94844076 4.407096614 5867 "RAB4A, member RAS oncogene family" "GO:0001671,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005829,GO:0005886,GO:0006661,GO:0015031,GO:0019003,GO:0019882,GO:0019905,GO:0030100,GO:0030659,GO:0031901,GO:0031982,GO:0032482,GO:0032593,GO:0032781,GO:0035255,GO:0043231,GO:0048471,GO:0051117,GO:0055038,GO:0070062,GO:0098837,GO:0098993" ATPase activator activity|GTPase activity|protein binding|GTP binding|endosome|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|protein transport|GDP binding|antigen processing and presentation|syntaxin binding|regulation of endocytosis|cytoplasmic vesicle membrane|early endosome membrane|vesicle|Rab protein signal transduction|insulin-responsive compartment|positive regulation of ATPase activity|ionotropic glutamate receptor binding|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|ATPase binding|recycling endosome membrane|extracellular exosome|postsynaptic recycling endosome|anchored component of synaptic vesicle membrane hsa04144 Endocytosis RAB4B 176.5941861 144.6175297 208.5708425 1.442223795 0.52829505 0.166397381 1 6.659164593 9.443295602 53916 "RAB4B, member RAS oncogene family" "GO:0003674,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005886,GO:0015031,GO:0030100,GO:0030667,GO:0032482,GO:0032593,GO:0043312,GO:0046323,GO:0048471,GO:0055037" molecular_function|GTPase activity|protein binding|GTP binding|endosome|plasma membrane|protein transport|regulation of endocytosis|secretory granule membrane|Rab protein signal transduction|insulin-responsive compartment|neutrophil degranulation|glucose import|perinuclear region of cytoplasm|recycling endosome RAB5A 1336.133999 1075.787955 1596.480043 1.484009963 0.569500778 0.017905929 0.773499658 22.80096343 33.27064293 5868 "RAB5A, member RAS oncogene family" "GO:0001726,GO:0003924,GO:0005515,GO:0005525,GO:0005654,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0006661,GO:0006886,GO:0006897,GO:0006909,GO:0007596,GO:0008021,GO:0010008,GO:0012505,GO:0015629,GO:0019003,GO:0030100,GO:0030139,GO:0030424,GO:0030425,GO:0030665,GO:0030670,GO:0031901,GO:0032009,GO:0036465,GO:0036477,GO:0039694,GO:0042470,GO:0043025,GO:0043195,GO:0043231,GO:0043679,GO:0043687,GO:0045022,GO:0045121,GO:0045335,GO:0045921,GO:0048169,GO:0051036,GO:0051489,GO:0061024,GO:0070062,GO:0098559,GO:0098842,GO:0098993,GO:0150093,GO:2000286,GO:2000300,GO:2000785" ruffle|GTPase activity|protein binding|GTP binding|nucleoplasm|cytoplasm|endosome|early endosome|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|intracellular protein transport|endocytosis|phagocytosis|blood coagulation|synaptic vesicle|endosome membrane|endomembrane system|actin cytoskeleton|GDP binding|regulation of endocytosis|endocytic vesicle|axon|dendrite|clathrin-coated vesicle membrane|phagocytic vesicle membrane|early endosome membrane|early phagosome|synaptic vesicle recycling|somatodendritic compartment|viral RNA genome replication|melanosome|neuronal cell body|terminal bouton|intracellular membrane-bounded organelle|axon terminus|post-translational protein modification|early endosome to late endosome transport|membrane raft|phagocytic vesicle|positive regulation of exocytosis|regulation of long-term neuronal synaptic plasticity|regulation of endosome size|regulation of filopodium assembly|membrane organization|extracellular exosome|cytoplasmic side of early endosome membrane|postsynaptic early endosome|anchored component of synaptic vesicle membrane|amyloid-beta clearance by transcytosis|receptor internalization involved in canonical Wnt signaling pathway|regulation of synaptic vesicle exocytosis|regulation of autophagosome assembly "hsa04014,hsa04144,hsa04145,hsa04962,hsa05014,hsa05022,hsa05132,hsa05146,hsa05152" Ras signaling pathway|Endocytosis|Phagosome|Vasopressin-regulated water reabsorption|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Salmonella infection|Amoebiasis|Tuberculosis RAB5B 763.3560892 800.0782758 726.6339027 0.908203516 -0.138912474 0.585737249 1 11.67907743 10.42948575 5869 "RAB5B, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005769,GO:0005886,GO:0006886,GO:0006897,GO:0007032,GO:0012505,GO:0016020,GO:0019003,GO:0019882,GO:0030100,GO:0030139,GO:0030667,GO:0030742,GO:0031901,GO:0042470,GO:0043231,GO:0043312,GO:0048227,GO:0070062,GO:0098993" GTPase activity|protein binding|GTP binding|endosome|early endosome|plasma membrane|intracellular protein transport|endocytosis|endosome organization|endomembrane system|membrane|GDP binding|antigen processing and presentation|regulation of endocytosis|endocytic vesicle|secretory granule membrane|GTP-dependent protein binding|early endosome membrane|melanosome|intracellular membrane-bounded organelle|neutrophil degranulation|plasma membrane to endosome transport|extracellular exosome|anchored component of synaptic vesicle membrane "hsa04014,hsa04144,hsa04145,hsa04962,hsa05132,hsa05146,hsa05152" Ras signaling pathway|Endocytosis|Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection|Amoebiasis|Tuberculosis RAB5C 3161.312212 3105.63544 3216.988985 1.035855318 0.05082251 0.831265164 1 84.00509655 85.56101221 5878 "RAB5C, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005765,GO:0005768,GO:0005769,GO:0005811,GO:0005886,GO:0006886,GO:0006897,GO:0012505,GO:0019003,GO:0030100,GO:0030139,GO:0031901,GO:0035577,GO:0042470,GO:0043312,GO:0048227,GO:0070062" GTPase activity|protein binding|GTP binding|lysosomal membrane|endosome|early endosome|lipid droplet|plasma membrane|intracellular protein transport|endocytosis|endomembrane system|GDP binding|regulation of endocytosis|endocytic vesicle|early endosome membrane|azurophil granule membrane|melanosome|neutrophil degranulation|plasma membrane to endosome transport|extracellular exosome "hsa04014,hsa04144,hsa04145,hsa04962,hsa05132,hsa05146,hsa05152" Ras signaling pathway|Endocytosis|Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection|Amoebiasis|Tuberculosis RAB5IF 280.2348687 253.8609874 306.60875 1.207782075 0.272360166 0.401612571 1 12.46374822 14.80159189 55969 RAB5 interacting factor "GO:0003674,GO:0005515,GO:0005746,GO:0016021,GO:0097250" molecular_function|protein binding|mitochondrial respirasome|integral component of membrane|mitochondrial respirasome assembly RAB6A 3673.338537 3477.063196 3869.613879 1.112897195 0.154320329 0.516344596 1 53.32312419 58.35012802 5870 "RAB6A, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005789,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0006886,GO:0006890,GO:0006891,GO:0012505,GO:0016020,GO:0016032,GO:0018125,GO:0019882,GO:0019904,GO:0030667,GO:0031410,GO:0031489,GO:0032588,GO:0034067,GO:0034498,GO:0042147,GO:0043312,GO:0070062,GO:0070381,GO:0072385" "Golgi membrane|GTPase activity|protein binding|GTP binding|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|endomembrane system|membrane|viral process|peptidyl-cysteine methylation|antigen processing and presentation|protein domain specific binding|secretory granule membrane|cytoplasmic vesicle|myosin V binding|trans-Golgi network membrane|protein localization to Golgi apparatus|early endosome to Golgi transport|retrograde transport, endosome to Golgi|neutrophil degranulation|extracellular exosome|endosome to plasma membrane transport vesicle|minus-end-directed organelle transport along microtubule" RAB6B 59.45769113 34.33365813 84.58172413 2.463522058 1.300722389 0.02221858 0.822216713 0.321912198 0.779767387 51560 "RAB6B, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005793,GO:0005794,GO:0005829,GO:0006886,GO:0006890,GO:0006891,GO:0012505,GO:0031410,GO:0031489,GO:0042147,GO:0098793" "Golgi membrane|GTPase activity|protein binding|GTP binding|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|endomembrane system|cytoplasmic vesicle|myosin V binding|retrograde transport, endosome to Golgi|presynapse" RAB6C 22.29467097 30.1720026 14.41733934 0.47783833 -1.065405509 0.194403184 1 0.523990994 0.246193162 84084 "RAB6C, member RAS oncogene family" "GO:0000278,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005794,GO:0005813,GO:0005829,GO:0006886,GO:0006890,GO:0006891,GO:0007264,GO:0010824,GO:0012505,GO:0042147,GO:0042493" "mitotic cell cycle|GTPase activity|protein binding|GTP binding|nucleus|Golgi apparatus|centrosome|cytosol|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|small GTPase mediated signal transduction|regulation of centrosome duplication|endomembrane system|retrograde transport, endosome to Golgi|response to drug" RAB6D 11.40995416 9.363724944 13.45618338 1.437054534 0.523114811 0.682534404 1 0.135905573 0.192035576 150786 "RAB6D, member RAS oncogene family" "GO:0003924,GO:0005525,GO:0005794,GO:0005829,GO:0006886,GO:0006890,GO:0006891,GO:0012505,GO:0042147" "GTPase activity|GTP binding|Golgi apparatus|cytosol|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|intra-Golgi vesicle-mediated transport|endomembrane system|retrograde transport, endosome to Golgi" RAB7A 6662.640275 6293.463576 7031.816974 1.117320675 0.160043304 0.511385468 1 153.7165145 168.8766254 7879 "RAB7A, member RAS oncogene family" "GO:0000045,GO:0000421,GO:0003924,GO:0005515,GO:0005525,GO:0005764,GO:0005765,GO:0005770,GO:0005811,GO:0005829,GO:0005886,GO:0006622,GO:0006897,GO:0007174,GO:0008333,GO:0010008,GO:0015031,GO:0016042,GO:0019003,GO:0019076,GO:0019886,GO:0022615,GO:0030667,GO:0030670,GO:0030904,GO:0031902,GO:0032419,GO:0033162,GO:0042147,GO:0043312,GO:0045022,GO:0045335,GO:0045732,GO:0048524,GO:0061724,GO:0070062,GO:0090382,GO:0090383,GO:0090385,GO:0099638,GO:1902586,GO:1903542,GO:1903543,GO:1905366,GO:1905394" "autophagosome assembly|autophagosome membrane|GTPase activity|protein binding|GTP binding|lysosome|lysosomal membrane|late endosome|lipid droplet|cytosol|plasma membrane|protein targeting to lysosome|endocytosis|epidermal growth factor catabolic process|endosome to lysosome transport|endosome membrane|protein transport|lipid catabolic process|GDP binding|viral release from host cell|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein to membrane docking|secretory granule membrane|phagocytic vesicle membrane|retromer complex|late endosome membrane|extrinsic component of lysosome membrane|melanosome membrane|retrograde transport, endosome to Golgi|neutrophil degranulation|early endosome to late endosome transport|phagocytic vesicle|positive regulation of protein catabolic process|positive regulation of viral process|lipophagy|extracellular exosome|phagosome maturation|phagosome acidification|phagosome-lysosome fusion|endosome to plasma membrane protein transport|multi-organism intercellular transport|negative regulation of exosomal secretion|positive regulation of exosomal secretion|negative regulation of intralumenal vesicle formation|retromer complex binding" "hsa04137,hsa04140,hsa04144,hsa04145,hsa05132,hsa05146,hsa05152" Mitophagy - animal|Autophagy - animal|Endocytosis|Phagosome|Salmonella infection|Amoebiasis|Tuberculosis RAB8A 1212.426699 1171.506032 1253.347367 1.069859935 0.097421932 0.689429226 1 24.35571632 25.62117303 4218 "RAB8A, member RAS oncogene family" "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0005929,GO:0006904,GO:0006914,GO:0007409,GO:0008021,GO:0009306,GO:0010506,GO:0014069,GO:0017157,GO:0019003,GO:0019901,GO:0030140,GO:0030496,GO:0030670,GO:0031267,GO:0031489,GO:0032588,GO:0032869,GO:0043025,GO:0043197,GO:0043687,GO:0045335,GO:0048169,GO:0048210,GO:0051223,GO:0055038,GO:0060271,GO:0070062,GO:0072659,GO:0097730,GO:0098887,GO:0098969,GO:0098978,GO:0099003" "Golgi membrane|GTPase activity|protein binding|GTP binding|endosome|centrosome|centriole|cytosol|plasma membrane|cilium|vesicle docking involved in exocytosis|autophagy|axonogenesis|synaptic vesicle|protein secretion|regulation of autophagy|postsynaptic density|regulation of exocytosis|GDP binding|protein kinase binding|trans-Golgi network transport vesicle|midbody|phagocytic vesicle membrane|small GTPase binding|myosin V binding|trans-Golgi network membrane|cellular response to insulin stimulus|neuronal cell body|dendritic spine|post-translational protein modification|phagocytic vesicle|regulation of long-term neuronal synaptic plasticity|Golgi vesicle fusion to target membrane|regulation of protein transport|recycling endosome membrane|cilium assembly|extracellular exosome|protein localization to plasma membrane|non-motile cilium|neurotransmitter receptor transport, endosome to postsynaptic membrane|neurotransmitter receptor transport to postsynaptic membrane|glutamatergic synapse|vesicle-mediated transport in synapse" "hsa04140,hsa04144,hsa04152,hsa04530,hsa04972,hsa05014,hsa05022" Autophagy - animal|Endocytosis|AMPK signaling pathway|Tight junction|Pancreatic secretion|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases RAB8B 1131.99657 1204.799276 1059.193864 0.879145501 -0.185826139 0.445840353 1 7.53609037 6.514454189 51762 "RAB8B, member RAS oncogene family" "GO:0003924,GO:0005102,GO:0005515,GO:0005525,GO:0005654,GO:0005768,GO:0005778,GO:0005886,GO:0006904,GO:0008021,GO:0009306,GO:0016604,GO:0017157,GO:0019003,GO:0019882,GO:0030140,GO:0030670,GO:0030911,GO:0031346,GO:0032869,GO:0043231,GO:0045046,GO:0045335,GO:0048210,GO:0048471,GO:0051286,GO:0051461,GO:0055038,GO:0060271,GO:0070062,GO:0072659,GO:0150115" GTPase activity|signaling receptor binding|protein binding|GTP binding|nucleoplasm|endosome|peroxisomal membrane|plasma membrane|vesicle docking involved in exocytosis|synaptic vesicle|protein secretion|nuclear body|regulation of exocytosis|GDP binding|antigen processing and presentation|trans-Golgi network transport vesicle|phagocytic vesicle membrane|TPR domain binding|positive regulation of cell projection organization|cellular response to insulin stimulus|intracellular membrane-bounded organelle|protein import into peroxisome membrane|phagocytic vesicle|Golgi vesicle fusion to target membrane|perinuclear region of cytoplasm|cell tip|positive regulation of corticotropin secretion|recycling endosome membrane|cilium assembly|extracellular exosome|protein localization to plasma membrane|cell-substrate junction organization hsa04530 Tight junction RAB9A 642.4649036 565.9851522 718.9446551 1.270253561 0.345116509 0.184156189 1 14.85033792 18.54803625 9367 "RAB9A, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005764,GO:0005770,GO:0005789,GO:0005829,GO:0005886,GO:0015031,GO:0019003,GO:0030133,GO:0030670,GO:0032482,GO:0032588,GO:0032880,GO:0042147,GO:0042470,GO:0045335,GO:0045921,GO:0052405,GO:0070062" "GTPase activity|protein binding|GTP binding|lysosome|late endosome|endoplasmic reticulum membrane|cytosol|plasma membrane|protein transport|GDP binding|transport vesicle|phagocytic vesicle membrane|Rab protein signal transduction|trans-Golgi network membrane|regulation of protein localization|retrograde transport, endosome to Golgi|melanosome|phagocytic vesicle|positive regulation of exocytosis|negative regulation by host of symbiont molecular function|extracellular exosome" "hsa05132,hsa05162" Salmonella infection|Measles RAB9B 31.70305529 37.45489978 25.95121081 0.692865579 -0.529352609 0.470971744 1 0.529930849 0.361026737 51209 "RAB9B, member RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005764,GO:0005770,GO:0005829,GO:0005886,GO:0015031,GO:0019003,GO:0030667,GO:0030670,GO:0032482,GO:0042147,GO:0042802,GO:0043312,GO:0045335" "GTPase activity|protein binding|GTP binding|lysosome|late endosome|cytosol|plasma membrane|protein transport|GDP binding|secretory granule membrane|phagocytic vesicle membrane|Rab protein signal transduction|retrograde transport, endosome to Golgi|identical protein binding|neutrophil degranulation|phagocytic vesicle" "hsa05132,hsa05162" Salmonella infection|Measles RABAC1 945.4605444 786.5528953 1104.368193 1.404060935 0.489605549 0.047653771 1 55.96917653 77.26913526 10567 Rab acceptor 1 "GO:0005515,GO:0005794,GO:0005886,GO:0008021,GO:0008022,GO:0016020,GO:0016021,GO:0042802,GO:0070064" protein binding|Golgi apparatus|plasma membrane|synaptic vesicle|protein C-terminus binding|membrane|integral component of membrane|identical protein binding|proline-rich region binding RABEP1 1375.712543 1446.175297 1305.249788 0.902552955 -0.147916513 0.538462828 1 16.82208318 14.92875695 9135 "rabaptin, RAB GTPase binding effector protein 1" "GO:0005096,GO:0005515,GO:0005768,GO:0005769,GO:0006893,GO:0006897,GO:0006915,GO:0007165,GO:0008083,GO:0015031,GO:0016192,GO:0019904,GO:0030139,GO:0031901,GO:0032991,GO:0042803,GO:0043231,GO:0043547,GO:0055037,GO:0061025,GO:1903441" GTPase activator activity|protein binding|endosome|early endosome|Golgi to plasma membrane transport|endocytosis|apoptotic process|signal transduction|growth factor activity|protein transport|vesicle-mediated transport|protein domain specific binding|endocytic vesicle|early endosome membrane|protein-containing complex|protein homodimerization activity|intracellular membrane-bounded organelle|positive regulation of GTPase activity|recycling endosome|membrane fusion|protein localization to ciliary membrane hsa04144 Endocytosis RABEP2 154.0019907 157.1024963 150.9014851 0.960528882 -0.0580991 0.901349678 1 3.634274592 3.43241147 79874 "rabaptin, RAB GTPase binding effector protein 2" "GO:0005096,GO:0005515,GO:0005769,GO:0005813,GO:0005829,GO:0006897,GO:0007165,GO:0008083,GO:0015031,GO:0030030,GO:0036064,GO:0043231,GO:0043547,GO:1902017" GTPase activator activity|protein binding|early endosome|centrosome|cytosol|endocytosis|signal transduction|growth factor activity|protein transport|cell projection organization|ciliary basal body|intracellular membrane-bounded organelle|positive regulation of GTPase activity|regulation of cilium assembly RABEPK 524.3666383 556.6214272 492.1118495 0.884105112 -0.177710191 0.513815466 1 13.80383947 11.99982688 10244 Rab9 effector protein with kelch motifs "GO:0005515,GO:0005768,GO:0005829,GO:0006898,GO:0006904,GO:0010008,GO:0030133,GO:0032588" protein binding|endosome|cytosol|receptor-mediated endocytosis|vesicle docking involved in exocytosis|endosome membrane|transport vesicle|trans-Golgi network membrane RABGAP1 2088.831855 2088.110662 2089.553048 1.000690761 0.000996214 0.998977285 1 17.71116152 17.42681868 23637 RAB GTPase activating protein 1 "GO:0005096,GO:0005515,GO:0005813,GO:0005829,GO:0005875,GO:0006886,GO:0007049,GO:0015631,GO:0031267,GO:0043087,GO:0090630,GO:1902017" GTPase activator activity|protein binding|centrosome|cytosol|microtubule associated complex|intracellular protein transport|cell cycle|tubulin binding|small GTPase binding|regulation of GTPase activity|activation of GTPase activity|regulation of cilium assembly RABGAP1L 691.0775069 580.5509465 801.6040673 1.380764379 0.465467152 0.069832882 1 2.393059165 3.248958689 9910 RAB GTPase activating protein 1 like "GO:0005096,GO:0005634,GO:0005769,GO:0005794,GO:0006886,GO:0006897,GO:0031267,GO:0032880,GO:0090630" GTPase activator activity|nucleus|early endosome|Golgi apparatus|intracellular protein transport|endocytosis|small GTPase binding|regulation of protein localization|activation of GTPase activity RABGEF1 1281.812367 1315.083148 1248.541587 0.949401252 -0.074910143 0.758302645 1 10.04200466 9.374355029 27342 RAB guanine nucleotide exchange factor 1 "GO:0003677,GO:0005085,GO:0005515,GO:0005730,GO:0005769,GO:0005829,GO:0006612,GO:0006897,GO:0008270,GO:0031267,GO:0031901,GO:0050790,GO:0055037" DNA binding|guanyl-nucleotide exchange factor activity|protein binding|nucleolus|early endosome|cytosol|protein targeting to membrane|endocytosis|zinc ion binding|small GTPase binding|early endosome membrane|regulation of catalytic activity|recycling endosome RABGGTA 321.8168254 323.5687175 320.0649333 0.989171437 -0.015707513 0.970537318 1 8.873724439 8.630752927 5875 Rab geranylgeranyltransferase subunit alpha "GO:0004663,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005968,GO:0006464,GO:0007601,GO:0008270,GO:0018215,GO:0018344,GO:0031267,GO:0042981,GO:0043687" Rab geranylgeranyltransferase activity|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|Rab-protein geranylgeranyltransferase complex|cellular protein modification process|visual perception|zinc ion binding|protein phosphopantetheinylation|protein geranylgeranylation|small GTPase binding|regulation of apoptotic process|post-translational protein modification RABGGTB 1908.784919 1865.462092 1952.107747 1.046447288 0.065499642 0.783834566 1 68.75433926 70.743843 5876 Rab geranylgeranyltransferase subunit beta "GO:0004663,GO:0005515,GO:0005829,GO:0005886,GO:0005968,GO:0006464,GO:0007601,GO:0008270,GO:0018215,GO:0018342,GO:0018344,GO:0031267,GO:0042981,GO:0043687" Rab geranylgeranyltransferase activity|protein binding|cytosol|plasma membrane|Rab-protein geranylgeranyltransferase complex|cellular protein modification process|visual perception|zinc ion binding|protein phosphopantetheinylation|protein prenylation|protein geranylgeranylation|small GTPase binding|regulation of apoptotic process|post-translational protein modification RABIF 266.8875113 281.9521622 251.8228605 0.893140377 -0.16304115 0.625518029 1 4.824388807 4.236753562 5877 RAB interacting factor "GO:0005085,GO:0005515,GO:0005829,GO:0006892,GO:0007264,GO:0008270,GO:0015031,GO:0016020,GO:0050790,GO:0061025" guanyl-nucleotide exchange factor activity|protein binding|cytosol|post-Golgi vesicle-mediated transport|small GTPase mediated signal transduction|zinc ion binding|protein transport|membrane|regulation of catalytic activity|membrane fusion RABL2A 68.21692079 62.42483296 74.00900861 1.18556999 0.245580835 0.664476762 1 0.876479506 1.021739403 11159 "RAB, member of RAS oncogene family like 2A" "GO:0003924,GO:0005525,GO:0006886,GO:0012505" GTPase activity|GTP binding|intracellular protein transport|endomembrane system RABL2B 293.5967029 289.2350594 297.9583464 1.030159853 0.042868223 0.903362355 1 3.465636176 3.510417475 11158 "RAB, member of RAS oncogene family like 2B" "GO:0000242,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005814,GO:0006886,GO:0012505,GO:0036064,GO:0042073,GO:0060271" pericentriolar material|GTPase activity|protein binding|GTP binding|cytoplasm|centriole|intracellular protein transport|endomembrane system|ciliary basal body|intraciliary transport|cilium assembly RABL3 422.9803906 418.2463808 427.7144004 1.022637421 0.032294725 0.918422805 1 3.841170305 3.862392652 285282 "RAB, member of RAS oncogene family like 3" "GO:0001779,GO:0003924,GO:0005515,GO:0005525,GO:0006886,GO:0012505,GO:0030183,GO:0033077,GO:0042803,GO:0046578,GO:0050821,GO:1903059" natural killer cell differentiation|GTPase activity|protein binding|GTP binding|intracellular protein transport|endomembrane system|B cell differentiation|T cell differentiation in thymus|protein homodimerization activity|regulation of Ras protein signal transduction|protein stabilization|regulation of protein lipidation RABL6 2055.607808 2048.574935 2062.640682 1.006866113 0.009871855 0.968986843 1 28.71780382 28.43113041 55684 "RAB, member RAS oncogene family like 6" "GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005813,GO:0005829" protein binding|GTP binding|nucleus|cytoplasm|centrosome|cytosol RAC1 9157.813387 8350.361822 9965.264952 1.193393192 0.255069452 0.306469305 1 188.3531121 221.0179441 5879 Rac family small GTPase 1 "GO:0000139,GO:0001764,GO:0001934,GO:0002551,GO:0003376,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005789,GO:0005802,GO:0005829,GO:0005856,GO:0005884,GO:0005886,GO:0005925,GO:0005938,GO:0006954,GO:0007015,GO:0007155,GO:0007160,GO:0007163,GO:0007596,GO:0008045,GO:0008283,GO:0008360,GO:0008361,GO:0009611,GO:0009653,GO:0010310,GO:0010591,GO:0010592,GO:0010595,GO:0010764,GO:0010811,GO:0016020,GO:0016601,GO:0019899,GO:0019901,GO:0030027,GO:0030031,GO:0030032,GO:0030036,GO:0030041,GO:0030334,GO:0030667,GO:0030865,GO:0031116,GO:0031234,GO:0031295,GO:0031410,GO:0031529,GO:0031996,GO:0032587,GO:0032707,GO:0032956,GO:0034446,GO:0035025,GO:0035556,GO:0035774,GO:0036464,GO:0038095,GO:0038096,GO:0042470,GO:0042826,GO:0042995,GO:0043197,GO:0043231,GO:0043312,GO:0043652,GO:0044877,GO:0045428,GO:0045453,GO:0045740,GO:0048010,GO:0048012,GO:0048013,GO:0048261,GO:0048870,GO:0050690,GO:0051022,GO:0051056,GO:0051117,GO:0051492,GO:0051496,GO:0051668,GO:0051894,GO:0051897,GO:0055038,GO:0060071,GO:0060263,GO:0070062,GO:0071260,GO:0071526,GO:0090023,GO:0097178,GO:0098794,GO:0098978,GO:0101003,GO:1900026,GO:1902622" "Golgi membrane|neuron migration|positive regulation of protein phosphorylation|mast cell chemotaxis|sphingosine-1-phosphate receptor signaling pathway|GTPase activity|protein binding|GTP binding|cytoplasm|endoplasmic reticulum membrane|trans-Golgi network|cytosol|cytoskeleton|actin filament|plasma membrane|focal adhesion|cell cortex|inflammatory response|actin filament organization|cell adhesion|cell-matrix adhesion|establishment or maintenance of cell polarity|blood coagulation|motor neuron axon guidance|cell population proliferation|regulation of cell shape|regulation of cell size|response to wounding|anatomical structure morphogenesis|regulation of hydrogen peroxide metabolic process|regulation of lamellipodium assembly|positive regulation of lamellipodium assembly|positive regulation of endothelial cell migration|negative regulation of fibroblast migration|positive regulation of cell-substrate adhesion|membrane|Rac protein signal transduction|enzyme binding|protein kinase binding|lamellipodium|cell projection assembly|lamellipodium assembly|actin cytoskeleton organization|actin filament polymerization|regulation of cell migration|secretory granule membrane|cortical cytoskeleton organization|positive regulation of microtubule polymerization|extrinsic component of cytoplasmic side of plasma membrane|T cell costimulation|cytoplasmic vesicle|ruffle organization|thioesterase binding|ruffle membrane|negative regulation of interleukin-23 production|regulation of actin cytoskeleton organization|substrate adhesion-dependent cell spreading|positive regulation of Rho protein signal transduction|intracellular signal transduction|positive regulation of insulin secretion involved in cellular response to glucose stimulus|cytoplasmic ribonucleoprotein granule|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|melanosome|histone deacetylase binding|cell projection|dendritic spine|intracellular membrane-bounded organelle|neutrophil degranulation|engulfment of apoptotic cell|protein-containing complex binding|regulation of nitric oxide biosynthetic process|bone resorption|positive regulation of DNA replication|vascular endothelial growth factor receptor signaling pathway|hepatocyte growth factor receptor signaling pathway|ephrin receptor signaling pathway|negative regulation of receptor-mediated endocytosis|cell motility|regulation of defense response to virus by virus|Rho GDP-dissociation inhibitor binding|regulation of small GTPase mediated signal transduction|ATPase binding|regulation of stress fiber assembly|positive regulation of stress fiber assembly|localization within membrane|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|recycling endosome membrane|Wnt signaling pathway, planar cell polarity pathway|regulation of respiratory burst|extracellular exosome|cellular response to mechanical stimulus|semaphorin-plexin signaling pathway|positive regulation of neutrophil chemotaxis|ruffle assembly|postsynapse|glutamatergic synapse|ficolin-1-rich granule membrane|positive regulation of substrate adhesion-dependent cell spreading|regulation of neutrophil migration" "hsa04010,hsa04014,hsa04015,hsa04024,hsa04062,hsa04071,hsa04145,hsa04151,hsa04310,hsa04360,hsa04370,hsa04380,hsa04510,hsa04520,hsa04530,hsa04620,hsa04650,hsa04662,hsa04664,hsa04666,hsa04670,hsa04722,hsa04810,hsa04932,hsa04933,hsa04972,hsa05014,hsa05020,hsa05022,hsa05100,hsa05120,hsa05130,hsa05131,hsa05132,hsa05135,hsa05163,hsa05167,hsa05169,hsa05170,hsa05200,hsa05203,hsa05205,hsa05210,hsa05211,hsa05212,hsa05231,hsa05416,hsa05418" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Phagosome|PI3K-Akt signaling pathway|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Adherens junction|Tight junction|Toll-like receptor signaling pathway|Natural killer cell mediated cytotoxicity|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Pancreatic secretion|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Bacterial invasion of epithelial cells|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Choline metabolism in cancer|Viral myocarditis|Fluid shear stress and atherosclerosis RAC2 4400.097087 4161.655531 4638.538644 1.114589761 0.156512806 0.512547782 1 135.5921287 148.6006492 5880 Rac family small GTPase 2 "GO:0003924,GO:0005515,GO:0005525,GO:0005635,GO:0005829,GO:0005856,GO:0005884,GO:0005886,GO:0005925,GO:0005938,GO:0007015,GO:0007163,GO:0007165,GO:0007186,GO:0008045,GO:0008284,GO:0008360,GO:0010310,GO:0010592,GO:0010810,GO:0016601,GO:0019887,GO:0019901,GO:0030027,GO:0030031,GO:0030670,GO:0030865,GO:0031410,GO:0032956,GO:0042129,GO:0042995,GO:0043231,GO:0043304,GO:0043652,GO:0045453,GO:0045454,GO:0045859,GO:0051056,GO:0051897,GO:0060263,GO:0060753,GO:0070062,GO:0071593,GO:0090023,GO:1902622,GO:1903955" GTPase activity|protein binding|GTP binding|nuclear envelope|cytosol|cytoskeleton|actin filament|plasma membrane|focal adhesion|cell cortex|actin filament organization|establishment or maintenance of cell polarity|signal transduction|G protein-coupled receptor signaling pathway|motor neuron axon guidance|positive regulation of cell population proliferation|regulation of cell shape|regulation of hydrogen peroxide metabolic process|positive regulation of lamellipodium assembly|regulation of cell-substrate adhesion|Rac protein signal transduction|protein kinase regulator activity|protein kinase binding|lamellipodium|cell projection assembly|phagocytic vesicle membrane|cortical cytoskeleton organization|cytoplasmic vesicle|regulation of actin cytoskeleton organization|regulation of T cell proliferation|cell projection|intracellular membrane-bounded organelle|regulation of mast cell degranulation|engulfment of apoptotic cell|bone resorption|cell redox homeostasis|regulation of protein kinase activity|regulation of small GTPase mediated signal transduction|positive regulation of protein kinase B signaling|regulation of respiratory burst|regulation of mast cell chemotaxis|extracellular exosome|lymphocyte aggregation|positive regulation of neutrophil chemotaxis|regulation of neutrophil migration|positive regulation of protein targeting to mitochondrion "hsa04010,hsa04014,hsa04015,hsa04024,hsa04062,hsa04071,hsa04310,hsa04360,hsa04370,hsa04510,hsa04520,hsa04650,hsa04662,hsa04664,hsa04666,hsa04670,hsa04810,hsa05020,hsa05135,hsa05163,hsa05170,hsa05200,hsa05210,hsa05212,hsa05231,hsa05416,hsa05418" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Focal adhesion|Adherens junction|Natural killer cell mediated cytotoxicity|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Prion disease|Yersinia infection|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Choline metabolism in cancer|Viral myocarditis|Fluid shear stress and atherosclerosis RAC3 556.0797545 569.1063938 543.0531151 0.954220724 -0.067605075 0.805938896 1 29.26027193 27.4535418 5881 Rac family small GTPase 3 "GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0007015,GO:0007163,GO:0007264,GO:0008360,GO:0012505,GO:0014041,GO:0016055,GO:0019901,GO:0021894,GO:0030027,GO:0030031,GO:0030036,GO:0030426,GO:0030865,GO:0031175,GO:0031410,GO:0031941,GO:0032956,GO:0033630,GO:0035556,GO:0042995,GO:0043005,GO:0043025,GO:0043231,GO:0045202,GO:0048306,GO:0048471,GO:0048873,GO:0050885,GO:0051056,GO:0051932,GO:0070062,GO:0071944,GO:1900026" "GTPase activity|protein binding|GTP binding|cytosol|cytoskeleton|plasma membrane|cell cortex|actin filament organization|establishment or maintenance of cell polarity|small GTPase mediated signal transduction|regulation of cell shape|endomembrane system|regulation of neuron maturation|Wnt signaling pathway|protein kinase binding|cerebral cortex GABAergic interneuron development|lamellipodium|cell projection assembly|actin cytoskeleton organization|growth cone|cortical cytoskeleton organization|neuron projection development|cytoplasmic vesicle|filamentous actin|regulation of actin cytoskeleton organization|positive regulation of cell adhesion mediated by integrin|intracellular signal transduction|cell projection|neuron projection|neuronal cell body|intracellular membrane-bounded organelle|synapse|calcium-dependent protein binding|perinuclear region of cytoplasm|homeostasis of number of cells within a tissue|neuromuscular process controlling balance|regulation of small GTPase mediated signal transduction|synaptic transmission, GABAergic|extracellular exosome|cell periphery|positive regulation of substrate adhesion-dependent cell spreading" "hsa04010,hsa04014,hsa04015,hsa04024,hsa04062,hsa04071,hsa04310,hsa04360,hsa04370,hsa04510,hsa04520,hsa04650,hsa04662,hsa04664,hsa04810,hsa05135,hsa05163,hsa05170,hsa05200,hsa05210,hsa05212,hsa05231,hsa05416,hsa05418" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Focal adhesion|Adherens junction|Natural killer cell mediated cytotoxicity|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Regulation of actin cytoskeleton|Yersinia infection|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Choline metabolism in cancer|Viral myocarditis|Fluid shear stress and atherosclerosis other RACGAP1 4523.950384 4498.749629 4549.15114 1.011203449 0.016073289 0.947378529 1 60.82847715 60.48067991 29127 Rac GTPase activating protein 1 "GO:0000281,GO:0000915,GO:0001669,GO:0005096,GO:0005515,GO:0005547,GO:0005634,GO:0005654,GO:0005819,GO:0005829,GO:0005874,GO:0006890,GO:0007018,GO:0007283,GO:0007405,GO:0008017,GO:0008272,GO:0019886,GO:0019901,GO:0030496,GO:0031234,GO:0032154,GO:0032467,GO:0035556,GO:0043014,GO:0043015,GO:0043547,GO:0045995,GO:0046872,GO:0048487,GO:0051056,GO:0051233,GO:0051256,GO:0051988,GO:0070062,GO:0072686,GO:0090543,GO:0097149" "mitotic cytokinesis|actomyosin contractile ring assembly|acrosomal vesicle|GTPase activator activity|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|nucleoplasm|spindle|cytosol|microtubule|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|microtubule-based movement|spermatogenesis|neuroblast proliferation|microtubule binding|sulfate transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|midbody|extrinsic component of cytoplasmic side of plasma membrane|cleavage furrow|positive regulation of cytokinesis|intracellular signal transduction|alpha-tubulin binding|gamma-tubulin binding|positive regulation of GTPase activity|regulation of embryonic development|metal ion binding|beta-tubulin binding|regulation of small GTPase mediated signal transduction|spindle midzone|mitotic spindle midzone assembly|regulation of attachment of spindle microtubules to kinetochore|extracellular exosome|mitotic spindle|Flemming body|centralspindlin complex" RACK1 33262.4202 33654.26786 32870.57254 0.976713345 -0.033992886 0.909686177 1 1575.496861 1513.058928 10399 receptor for activated C kinase 1 "GO:0001891,GO:0001934,GO:0003723,GO:0005080,GO:0005102,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006915,GO:0006919,GO:0007049,GO:0007369,GO:0008200,GO:0008656,GO:0010629,GO:0010803,GO:0015935,GO:0016032,GO:0016567,GO:0017148,GO:0019899,GO:0019903,GO:0030178,GO:0030292,GO:0030308,GO:0030332,GO:0030335,GO:0030425,GO:0030496,GO:0030971,GO:0031334,GO:0032091,GO:0032436,GO:0032880,GO:0033137,GO:0035591,GO:0042169,GO:0042803,GO:0042998,GO:0043022,GO:0043025,GO:0043065,GO:0043204,GO:0043547,GO:0045296,GO:0045879,GO:0048471,GO:0048511,GO:0050765,GO:0051302,GO:0051343,GO:0051434,GO:0051726,GO:0051898,GO:0051901,GO:0060090,GO:0061099,GO:0070062,GO:0071333,GO:0071363,GO:0072344,GO:1900102,GO:1903208,GO:1990630,GO:2000114,GO:2000304,GO:2000543,GO:2001244" phagocytic cup|positive regulation of protein phosphorylation|RNA binding|protein kinase C binding|signaling receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell cycle|gastrulation|ion channel inhibitor activity|cysteine-type endopeptidase activator activity involved in apoptotic process|negative regulation of gene expression|regulation of tumor necrosis factor-mediated signaling pathway|small ribosomal subunit|viral process|protein ubiquitination|negative regulation of translation|enzyme binding|protein phosphatase binding|negative regulation of Wnt signaling pathway|protein tyrosine kinase inhibitor activity|negative regulation of cell growth|cyclin binding|positive regulation of cell migration|dendrite|midbody|receptor tyrosine kinase binding|positive regulation of protein-containing complex assembly|negative regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of protein localization|negative regulation of peptidyl-serine phosphorylation|signaling adaptor activity|SH2 domain binding|protein homodimerization activity|positive regulation of Golgi to plasma membrane protein transport|ribosome binding|neuronal cell body|positive regulation of apoptotic process|perikaryon|positive regulation of GTPase activity|cadherin binding|negative regulation of smoothened signaling pathway|perinuclear region of cytoplasm|rhythmic process|negative regulation of phagocytosis|regulation of cell division|positive regulation of cyclic-nucleotide phosphodiesterase activity|BH3 domain binding|regulation of cell cycle|negative regulation of protein kinase B signaling|positive regulation of mitochondrial depolarization|molecular adaptor activity|negative regulation of protein tyrosine kinase activity|extracellular exosome|cellular response to glucose stimulus|cellular response to growth factor stimulus|rescue of stalled ribosome|negative regulation of endoplasmic reticulum unfolded protein response|negative regulation of hydrogen peroxide-induced neuron death|IRE1-RACK1-PP2A complex|regulation of establishment of cell polarity|positive regulation of ceramide biosynthetic process|positive regulation of gastrulation|positive regulation of intrinsic apoptotic signaling pathway hsa05162 Measles RAD1 980.5660457 1026.888502 934.2435892 0.909780942 -0.136408881 0.581627652 1 12.14608866 10.86536851 5810 RAD1 checkpoint DNA exonuclease "GO:0000077,GO:0003684,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006260,GO:0006281,GO:0006974,GO:0008408,GO:0008853,GO:0021762,GO:0030896,GO:0043231,GO:0051598,GO:0071479,GO:0090305,GO:1901796" DNA damage checkpoint|damaged DNA binding|protein binding|nucleus|nucleoplasm|chromosome|DNA replication|DNA repair|cellular response to DNA damage stimulus|3'-5' exonuclease activity|exodeoxyribonuclease III activity|substantia nigra development|checkpoint clamp complex|intracellular membrane-bounded organelle|meiotic recombination checkpoint|cellular response to ionizing radiation|nucleic acid phosphodiester bond hydrolysis|regulation of signal transduction by p53 class mediator hsa04218 Cellular senescence RAD17 1024.189816 998.7973273 1049.582304 1.050846128 0.071551435 0.773741848 1 14.0978518 14.56676948 5884 RAD17 checkpoint clamp loader component "GO:0000076,GO:0000077,GO:0000781,GO:0003682,GO:0003689,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006260,GO:0006281,GO:0006974,GO:0008156,GO:0031389,GO:0031573,GO:0033314,GO:0042325,GO:1901796" "DNA replication checkpoint|DNA damage checkpoint|chromosome, telomeric region|chromatin binding|DNA clamp loader activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|DNA replication|DNA repair|cellular response to DNA damage stimulus|negative regulation of DNA replication|Rad17 RFC-like complex|intra-S DNA damage checkpoint|mitotic DNA replication checkpoint|regulation of phosphorylation|regulation of signal transduction by p53 class mediator" RAD18 1221.791039 1089.313335 1354.268742 1.243231583 0.314095059 0.194027375 1 9.623348886 11.76384907 56852 RAD18 E3 ubiquitin protein ligase "GO:0000403,GO:0003684,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0005737,GO:0005813,GO:0006281,GO:0006301,GO:0006513,GO:0006974,GO:0009411,GO:0016567,GO:0016604,GO:0031593,GO:0031625,GO:0035861,GO:0042405,GO:0042769,GO:0042802,GO:0044877,GO:0046872,GO:0051865,GO:0051984,GO:0060548,GO:0097505" "Y-form DNA binding|damaged DNA binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|replication fork|cytoplasm|centrosome|DNA repair|postreplication repair|protein monoubiquitination|cellular response to DNA damage stimulus|response to UV|protein ubiquitination|nuclear body|polyubiquitin modification-dependent protein binding|ubiquitin protein ligase binding|site of double-strand break|nuclear inclusion body|DNA damage response, detection of DNA damage|identical protein binding|protein-containing complex binding|metal ion binding|protein autoubiquitination|positive regulation of chromosome segregation|negative regulation of cell death|Rad6-Rad18 complex" RAD21 10312.87586 9857.921538 10767.83017 1.09230228 0.127372158 0.613376929 1 143.7429384 154.3833773 5885 RAD21 cohesin complex component "GO:0000775,GO:0000795,GO:0000922,GO:0003682,GO:0005515,GO:0005654,GO:0005694,GO:0005829,GO:0006302,GO:0006310,GO:0006357,GO:0006915,GO:0007064,GO:0007130,GO:0007131,GO:0007275,GO:0008278,GO:0010972,GO:0016020,GO:0016363,GO:0034990,GO:0034991,GO:0045841,GO:0045876,GO:0051301,GO:0071168,GO:1990414" "chromosome, centromeric region|synaptonemal complex|spindle pole|chromatin binding|protein binding|nucleoplasm|chromosome|cytosol|double-strand break repair|DNA recombination|regulation of transcription by RNA polymerase II|apoptotic process|mitotic sister chromatid cohesion|synaptonemal complex assembly|reciprocal meiotic recombination|multicellular organism development|cohesin complex|negative regulation of G2/M transition of mitotic cell cycle|membrane|nuclear matrix|nuclear mitotic cohesin complex|nuclear meiotic cohesin complex|negative regulation of mitotic metaphase/anaphase transition|positive regulation of sister chromatid cohesion|cell division|protein localization to chromatin|replication-born double-strand break repair via sister chromatid exchange" hsa04110 Cell cycle other RAD21L1 10.88974722 8.323311061 13.45618338 1.616686351 0.693039812 0.572357607 1 0.103254257 0.164136405 642636 RAD21 cohesin complex component like 1 "GO:0000795,GO:0000800,GO:0003682,GO:0005634,GO:0005694,GO:0007064,GO:0007130,GO:0007283,GO:0009566,GO:0030893,GO:0034990,GO:0034991,GO:0070197,GO:0072520,GO:1990414" synaptonemal complex|lateral element|chromatin binding|nucleus|chromosome|mitotic sister chromatid cohesion|synaptonemal complex assembly|spermatogenesis|fertilization|meiotic cohesin complex|nuclear mitotic cohesin complex|nuclear meiotic cohesin complex|meiotic attachment of telomere to nuclear envelope|seminiferous tubule development|replication-born double-strand break repair via sister chromatid exchange RAD23A 1942.286983 1811.36057 2073.213397 1.144561404 0.194794864 0.411010871 1 54.06542755 60.84570357 5886 "RAD23 homolog A, nucleotide excision repair protein" "GO:0000502,GO:0003684,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006289,GO:0016032,GO:0016579,GO:0019900,GO:0031593,GO:0031648,GO:0032434,GO:0032436,GO:0032991,GO:0034451,GO:0043130,GO:0043161,GO:0043231,GO:0045070,GO:0045787,GO:0070628,GO:1990381" proteasome complex|damaged DNA binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|nucleotide-excision repair|viral process|protein deubiquitination|kinase binding|polyubiquitin modification-dependent protein binding|protein destabilization|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein-containing complex|centriolar satellite|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|positive regulation of viral genome replication|positive regulation of cell cycle|proteasome binding|ubiquitin-specific protease binding "hsa03420,hsa04141" Nucleotide excision repair|Protein processing in endoplasmic reticulum RAD23B 5452.120182 5260.332591 5643.907774 1.072918428 0.101540395 0.673858529 1 64.62575559 68.17788382 5887 "RAD23 homolog B, nucleotide excision repair protein" "GO:0000502,GO:0000715,GO:0000717,GO:0000978,GO:0003684,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006289,GO:0006294,GO:0006457,GO:0007283,GO:0016579,GO:0031593,GO:0032434,GO:0043130,GO:0043161,GO:0048568,GO:0070628,GO:0070911,GO:0071942,GO:0098761" "proteasome complex|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|damaged DNA binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|cytosol|nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|protein folding|spermatogenesis|protein deubiquitination|polyubiquitin modification-dependent protein binding|regulation of proteasomal ubiquitin-dependent protein catabolic process|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|embryonic organ development|proteasome binding|global genome nucleotide-excision repair|XPC complex|cellular response to interleukin-7" "hsa03420,hsa04141" Nucleotide excision repair|Protein processing in endoplasmic reticulum RAD50 1748.787051 1878.987472 1618.58663 0.861414274 -0.215220864 0.364665999 1 12.12259526 10.26783422 10111 RAD50 double strand break repair protein "GO:0000014,GO:0000019,GO:0000722,GO:0000723,GO:0000724,GO:0000729,GO:0000781,GO:0000794,GO:0003677,GO:0003678,GO:0003691,GO:0005515,GO:0005524,GO:0005654,GO:0006260,GO:0006281,GO:0006302,GO:0006303,GO:0006310,GO:0006974,GO:0007004,GO:0007131,GO:0008408,GO:0016020,GO:0016032,GO:0030674,GO:0030870,GO:0031860,GO:0031954,GO:0032206,GO:0032508,GO:0033674,GO:0035861,GO:0042802,GO:0043047,GO:0046872,GO:0046940,GO:0051880,GO:0070192,GO:0090305,GO:1901796,GO:1904354" "single-stranded DNA endodeoxyribonuclease activity|regulation of mitotic recombination|telomere maintenance via recombination|telomere maintenance|double-strand break repair via homologous recombination|DNA double-strand break processing|chromosome, telomeric region|condensed nuclear chromosome|DNA binding|DNA helicase activity|double-stranded telomeric DNA binding|protein binding|ATP binding|nucleoplasm|DNA replication|DNA repair|double-strand break repair|double-strand break repair via nonhomologous end joining|DNA recombination|cellular response to DNA damage stimulus|telomere maintenance via telomerase|reciprocal meiotic recombination|3'-5' exonuclease activity|membrane|viral process|protein-macromolecule adaptor activity|Mre11 complex|telomeric 3' overhang formation|positive regulation of protein autophosphorylation|positive regulation of telomere maintenance|DNA duplex unwinding|positive regulation of kinase activity|site of double-strand break|identical protein binding|single-stranded telomeric DNA binding|metal ion binding|nucleoside monophosphate phosphorylation|G-quadruplex DNA binding|chromosome organization involved in meiotic cell cycle|nucleic acid phosphodiester bond hydrolysis|regulation of signal transduction by p53 class mediator|negative regulation of telomere capping" "hsa03440,hsa03450,hsa04218" Homologous recombination|Non-homologous end-joining|Cellular senescence RAD51 343.5617213 326.6899591 360.4334835 1.103289138 0.141810927 0.64471064 1 6.260266675 6.791306871 5888 RAD51 recombinase "GO:0000150,GO:0000228,GO:0000722,GO:0000724,GO:0000730,GO:0000781,GO:0000785,GO:0000793,GO:0000794,GO:0000800,GO:0001932,GO:0003682,GO:0003690,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005815,GO:0006268,GO:0006281,GO:0006310,GO:0006312,GO:0006974,GO:0007131,GO:0008022,GO:0008094,GO:0009636,GO:0010165,GO:0010212,GO:0010569,GO:0010833,GO:0016605,GO:0017116,GO:0019899,GO:0031297,GO:0032991,GO:0035861,GO:0036297,GO:0042148,GO:0042493,GO:0042802,GO:0048471,GO:0051106,GO:0051321,GO:0070182,GO:0070192,GO:0070317,GO:0071479,GO:0071480,GO:0072711,GO:0072719,GO:0072757,GO:1904631,GO:1990414,GO:1990426" "recombinase activity|nuclear chromosome|telomere maintenance via recombination|double-strand break repair via homologous recombination|DNA recombinase assembly|chromosome, telomeric region|chromatin|condensed chromosome|condensed nuclear chromosome|lateral element|regulation of protein phosphorylation|chromatin binding|double-stranded DNA binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial matrix|microtubule organizing center|DNA unwinding involved in DNA replication|DNA repair|DNA recombination|mitotic recombination|cellular response to DNA damage stimulus|reciprocal meiotic recombination|protein C-terminus binding|DNA-dependent ATPase activity|response to toxic substance|response to X-ray|response to ionizing radiation|regulation of double-strand break repair via homologous recombination|telomere maintenance via telomere lengthening|PML body|single-stranded DNA helicase activity|enzyme binding|replication fork processing|protein-containing complex|site of double-strand break|interstrand cross-link repair|strand invasion|response to drug|identical protein binding|perinuclear region of cytoplasm|positive regulation of DNA ligation|meiotic cell cycle|DNA polymerase binding|chromosome organization involved in meiotic cell cycle|negative regulation of G0 to G1 transition|cellular response to ionizing radiation|cellular response to gamma radiation|cellular response to hydroxyurea|cellular response to cisplatin|cellular response to camptothecin|response to glucoside|replication-born double-strand break repair via sister chromatid exchange|mitotic recombination-dependent replication fork processing" "hsa03440,hsa03460,hsa05200,hsa05212" Homologous recombination|Fanconi anemia pathway|Pathways in cancer|Pancreatic cancer RAD51AP1 838.6980057 771.9871009 905.4089105 1.172829066 0.229992763 0.358939372 1 19.04740302 21.96552916 10635 RAD51 associated protein 1 "GO:0000217,GO:0000724,GO:0000781,GO:0000785,GO:0003677,GO:0003690,GO:0003697,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006281,GO:0006974,GO:0010569,GO:0010845,GO:0032991,GO:0036297,GO:0051321,GO:0062037,GO:0071479,GO:1905168" "DNA secondary structure binding|double-strand break repair via homologous recombination|chromosome, telomeric region|chromatin|DNA binding|double-stranded DNA binding|single-stranded DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|chromosome|DNA repair|cellular response to DNA damage stimulus|regulation of double-strand break repair via homologous recombination|positive regulation of reciprocal meiotic recombination|protein-containing complex|interstrand cross-link repair|meiotic cell cycle|D-loop DNA binding|cellular response to ionizing radiation|positive regulation of double-strand break repair via homologous recombination" RAD51B 345.9941793 352.7003062 339.2880525 0.961972662 -0.0559322 0.861928903 1 2.03030602 1.920416421 5890 RAD51 paralog B "GO:0000400,GO:0000724,GO:0003677,GO:0003690,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005657,GO:0006281,GO:0006310,GO:0007131,GO:0007596,GO:0008094,GO:0010971,GO:0033063" four-way junction DNA binding|double-strand break repair via homologous recombination|DNA binding|double-stranded DNA binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|replication fork|DNA repair|DNA recombination|reciprocal meiotic recombination|blood coagulation|DNA-dependent ATPase activity|positive regulation of G2/M transition of mitotic cell cycle|Rad51B-Rad51C-Rad51D-XRCC2 complex hsa03440 Homologous recombination RAD51C 300.2008773 298.5987843 301.8029702 1.01073074 0.015398712 0.972823609 1 6.698473442 6.657060328 5889 RAD51 paralog C "GO:0000400,GO:0000707,GO:0000722,GO:0000724,GO:0003677,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005657,GO:0005737,GO:0005739,GO:0005829,GO:0006281,GO:0006310,GO:0007062,GO:0007066,GO:0007131,GO:0007141,GO:0007283,GO:0007596,GO:0008094,GO:0008821,GO:0010971,GO:0030054,GO:0033063,GO:0033065,GO:0043231,GO:0048471,GO:0048476" four-way junction DNA binding|meiotic DNA recombinase assembly|telomere maintenance via recombination|double-strand break repair via homologous recombination|DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|replication fork|cytoplasm|mitochondrion|cytosol|DNA repair|DNA recombination|sister chromatid cohesion|female meiosis sister chromatid cohesion|reciprocal meiotic recombination|male meiosis I|spermatogenesis|blood coagulation|DNA-dependent ATPase activity|crossover junction endodeoxyribonuclease activity|positive regulation of G2/M transition of mitotic cell cycle|cell junction|Rad51B-Rad51C-Rad51D-XRCC2 complex|Rad51C-XRCC3 complex|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|Holliday junction resolvase complex "hsa03440,hsa03460" Homologous recombination|Fanconi anemia pathway RAD51D 699.261195 744.93634 653.5860501 0.877371683 -0.188739951 0.463141929 1 3.958566497 3.415015952 5892 RAD51 paralog D "GO:0000400,GO:0000722,GO:0000723,GO:0000724,GO:0000781,GO:0003677,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005657,GO:0005737,GO:0005813,GO:0006281,GO:0007131,GO:0008094,GO:0033063,GO:0036297,GO:0042148,GO:0043015,GO:0051726" "four-way junction DNA binding|telomere maintenance via recombination|telomere maintenance|double-strand break repair via homologous recombination|chromosome, telomeric region|DNA binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|replication fork|cytoplasm|centrosome|DNA repair|reciprocal meiotic recombination|DNA-dependent ATPase activity|Rad51B-Rad51C-Rad51D-XRCC2 complex|interstrand cross-link repair|strand invasion|gamma-tubulin binding|regulation of cell cycle" hsa03440 Homologous recombination RAD52 404.8127766 382.8723088 426.7532445 1.114609844 0.1565388 0.59177672 1 4.213029161 4.617304521 5893 "RAD52 homolog, DNA repair protein" "GO:0000724,GO:0000730,GO:0003677,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0006302,GO:0006310,GO:0006312,GO:0006974,GO:0010792,GO:0032991,GO:0032993,GO:0034599,GO:0042802,GO:0045002,GO:2000819" double-strand break repair via homologous recombination|DNA recombinase assembly|DNA binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|double-strand break repair|DNA recombination|mitotic recombination|cellular response to DNA damage stimulus|DNA double-strand break processing involved in repair via single-strand annealing|protein-containing complex|protein-DNA complex|cellular response to oxidative stress|identical protein binding|double-strand break repair via single-strand annealing|regulation of nucleotide-excision repair hsa03440 Homologous recombination RAD54B 903.5508807 834.4119339 972.6898275 1.165718979 0.221220038 0.3737382 1 5.260606182 6.02977125 25788 RAD54 homolog B "GO:0000724,GO:0003677,GO:0003678,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0006312,GO:0007131,GO:0008340,GO:0010212,GO:0015616,GO:0032508,GO:0042493" double-strand break repair via homologous recombination|DNA binding|DNA helicase activity|RNA helicase activity|protein binding|ATP binding|nucleus|mitotic recombination|reciprocal meiotic recombination|determination of adult lifespan|response to ionizing radiation|DNA translocase activity|DNA duplex unwinding|response to drug hsa03440 Homologous recombination RAD54L 942.5318027 898.9175946 986.1460108 1.097037166 0.133612404 0.591047153 1 15.27334603 16.47504885 8438 RAD54 like "GO:0000733,GO:0003677,GO:0003678,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006281,GO:0006310,GO:0007131,GO:0008340,GO:0010212,GO:0015616,GO:0032508,GO:0032991,GO:0036310,GO:0042493,GO:0045003,GO:0046872,GO:0051321" DNA strand renaturation|DNA binding|DNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|DNA repair|DNA recombination|reciprocal meiotic recombination|determination of adult lifespan|response to ionizing radiation|DNA translocase activity|DNA duplex unwinding|protein-containing complex|annealing helicase activity|response to drug|double-strand break repair via synthesis-dependent strand annealing|metal ion binding|meiotic cell cycle hsa03440 Homologous recombination RAD54L2 656.3217927 664.824471 647.8191143 0.974421283 -0.03738245 0.891022429 1 3.546272876 3.397739587 23132 RAD54 like 2 "GO:0003677,GO:0003678,GO:0005515,GO:0005524,GO:0005634,GO:0032508" DNA binding|DNA helicase activity|protein binding|ATP binding|nucleus|DNA duplex unwinding RAD9A 224.5274522 254.9014012 194.1535031 0.7616808 -0.392741566 0.260056108 1 5.040244274 3.774815864 5883 RAD9 checkpoint clamp component A "GO:0000076,GO:0000077,GO:0005515,GO:0005634,GO:0005654,GO:0006260,GO:0006281,GO:0006974,GO:0008408,GO:0008853,GO:0017124,GO:0019899,GO:0019901,GO:0030896,GO:0031573,GO:0042826,GO:0071479,GO:0090305,GO:1901796" DNA replication checkpoint|DNA damage checkpoint|protein binding|nucleus|nucleoplasm|DNA replication|DNA repair|cellular response to DNA damage stimulus|3'-5' exonuclease activity|exodeoxyribonuclease III activity|SH3 domain binding|enzyme binding|protein kinase binding|checkpoint clamp complex|intra-S DNA damage checkpoint|histone deacetylase binding|cellular response to ionizing radiation|nucleic acid phosphodiester bond hydrolysis|regulation of signal transduction by p53 class mediator hsa04218 Cellular senescence RAD9B 14.16950472 18.72744989 9.61155956 0.513233762 -0.962312016 0.340500071 1 0.216424768 0.109217783 144715 RAD9 checkpoint clamp component B "GO:0000076,GO:0005515,GO:0005634,GO:0005654,GO:0006260,GO:0006281,GO:0008408,GO:0030896,GO:0031573,GO:0071479,GO:0090305,GO:1901796" DNA replication checkpoint|protein binding|nucleus|nucleoplasm|DNA replication|DNA repair|3'-5' exonuclease activity|checkpoint clamp complex|intra-S DNA damage checkpoint|cellular response to ionizing radiation|nucleic acid phosphodiester bond hydrolysis|regulation of signal transduction by p53 class mediator hsa04218 Cellular senescence RADX 658.5617507 572.2276355 744.8958659 1.301747451 0.380449582 0.141425366 1 8.204926705 10.50201466 55086 "RPA1 related single stranded DNA binding protein, X-linked" "GO:0003697,GO:0003723,GO:0005515,GO:0005657,GO:0006282,GO:0016607,GO:2000042" single-stranded DNA binding|RNA binding|protein binding|replication fork|regulation of DNA repair|nuclear speck|negative regulation of double-strand break repair via homologous recombination RAE1 1186.659156 1113.242854 1260.075458 1.131896291 0.178741779 0.461827649 1 23.28958255 25.92026992 8480 ribonucleic acid export 1 "GO:0000972,GO:0001650,GO:0003723,GO:0005515,GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005737,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0007049,GO:0008017,GO:0016032,GO:0016925,GO:0019083,GO:0043130,GO:0043657,GO:0051301,GO:0060236,GO:0060964,GO:0075733,GO:0097431,GO:1900034" transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|fibrillar center|RNA binding|protein binding|nucleus|nuclear envelope|nuclear pore|nucleoplasm|cytoplasm|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|cell cycle|microtubule binding|viral process|protein sumoylation|viral transcription|ubiquitin binding|host cell|cell division|regulation of mitotic spindle organization|regulation of gene silencing by miRNA|intracellular transport of virus|mitotic spindle pole|regulation of cellular response to heat "hsa03013,hsa05014,hsa05164" RNA transport|Amyotrophic lateral sclerosis|Influenza A RAET1E 6.564545421 8.323311061 4.80577978 0.577387982 -0.792387015 0.636893371 1 0.084112822 0.047753051 135250 retinoic acid early transcript 1E "GO:0005515,GO:0005615,GO:0005886,GO:0006955,GO:0009897,GO:0016021,GO:0042267,GO:0045954,GO:0046703,GO:0050776" protein binding|extracellular space|plasma membrane|immune response|external side of plasma membrane|integral component of membrane|natural killer cell mediated cytotoxicity|positive regulation of natural killer cell mediated cytotoxicity|natural killer cell lectin-like receptor binding|regulation of immune response hsa04650 Natural killer cell mediated cytotoxicity RAET1G 14.57082478 16.64662212 12.49502743 0.750604377 -0.413875392 0.719526004 1 0.39292332 0.289994711 353091 retinoic acid early transcript 1G "GO:0002729,GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0005886,GO:0006955,GO:0009897,GO:0016021,GO:0016032,GO:0031225,GO:0042267,GO:0046703" positive regulation of natural killer cell cytokine production|protein binding|extracellular region|extracellular space|endoplasmic reticulum|plasma membrane|immune response|external side of plasma membrane|integral component of membrane|viral process|anchored component of membrane|natural killer cell mediated cytotoxicity|natural killer cell lectin-like receptor binding hsa04650 Natural killer cell mediated cytotoxicity RAET1L 4.562975582 6.242483296 2.883467868 0.461910386 -1.11431511 0.584550016 1 0.24751104 0.112414797 154064 retinoic acid early transcript 1L "GO:0002376,GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0005886,GO:0006955,GO:0009897,GO:0016032,GO:0031225" immune system process|protein binding|extracellular region|extracellular space|endoplasmic reticulum|plasma membrane|immune response|external side of plasma membrane|viral process|anchored component of membrane hsa04650 Natural killer cell mediated cytotoxicity RAF1 2197.858275 2149.495082 2246.221469 1.044999585 0.06350237 0.789756811 1 32.07005924 32.95240062 5894 "Raf-1 proto-oncogene, serine/threonine kinase" "GO:0000165,GO:0000186,GO:0001666,GO:0002223,GO:0004672,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005741,GO:0005794,GO:0005829,GO:0005886,GO:0006468,GO:0006915,GO:0007165,GO:0007190,GO:0007507,GO:0008179,GO:0008285,GO:0010856,GO:0016607,GO:0019899,GO:0030154,GO:0030168,GO:0030878,GO:0031143,GO:0031267,GO:0031333,GO:0031434,GO:0033138,GO:0034220,GO:0035019,GO:0035023,GO:0035773,GO:0035994,GO:0042060,GO:0042802,GO:0042981,GO:0043066,GO:0043154,GO:0044877,GO:0045104,GO:0045595,GO:0045944,GO:0046872,GO:0048011,GO:0048538,GO:0060324,GO:0071550,GO:0106310,GO:0106311,GO:1902042,GO:2000145" MAPK cascade|activation of MAPKK activity|response to hypoxia|stimulatory C-type lectin receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial outer membrane|Golgi apparatus|cytosol|plasma membrane|protein phosphorylation|apoptotic process|signal transduction|activation of adenylate cyclase activity|heart development|adenylate cyclase binding|negative regulation of cell population proliferation|adenylate cyclase activator activity|nuclear speck|enzyme binding|cell differentiation|platelet activation|thyroid gland development|pseudopodium|small GTPase binding|negative regulation of protein-containing complex assembly|mitogen-activated protein kinase kinase binding|positive regulation of peptidyl-serine phosphorylation|ion transmembrane transport|somatic stem cell population maintenance|regulation of Rho protein signal transduction|insulin secretion involved in cellular response to glucose stimulus|response to muscle stretch|wound healing|identical protein binding|regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein-containing complex binding|intermediate filament cytoskeleton organization|regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|neurotrophin TRK receptor signaling pathway|thymus development|face development|death-inducing signaling complex assembly|protein serine kinase activity|protein threonine kinase activity|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of cell motility "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04068,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04210,hsa04218,hsa04270,hsa04360,hsa04370,hsa04371,hsa04510,hsa04540,hsa04550,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04720,hsa04722,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04914,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04928,hsa04929,hsa04935,hsa05010,hsa05022,hsa05034,hsa05132,hsa05152,hsa05160,hsa05161,hsa05163,hsa05164,hsa05165,hsa05167,hsa05170,hsa05200,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05235" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Cellular senescence|Vascular smooth muscle contraction|Axon guidance|VEGF signaling pathway|Apelin signaling pathway|Focal adhesion|Gap junction|Signaling pathways regulating pluripotency of stem cells|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Long-term potentiation|Neurotrophin signaling pathway|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|GnRH secretion|Growth hormone synthesis, secretion and action|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|Salmonella infection|Tuberculosis|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer" RAG1 58.80853646 55.14193578 62.47513714 1.132987739 0.180132249 0.774665892 1 0.417599513 0.465217852 5896 recombination activating 1 "GO:0002250,GO:0002331,GO:0003677,GO:0004519,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0006310,GO:0006955,GO:0008270,GO:0008542,GO:0010390,GO:0030183,GO:0033077,GO:0033151,GO:0042393,GO:0042803,GO:0043029,GO:0043154,GO:0043565,GO:0045582,GO:0046872,GO:0048538,GO:0051865,GO:0061630,GO:0070244,GO:0090305,GO:0097519,GO:1905347,GO:1990238,GO:2000822" adaptive immune response|pre-B cell allelic exclusion|DNA binding|endonuclease activity|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|DNA recombination|immune response|zinc ion binding|visual learning|histone monoubiquitination|B cell differentiation|T cell differentiation in thymus|V(D)J recombination|histone binding|protein homodimerization activity|T cell homeostasis|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|sequence-specific DNA binding|positive regulation of T cell differentiation|metal ion binding|thymus development|protein autoubiquitination|ubiquitin protein ligase activity|negative regulation of thymocyte apoptotic process|nucleic acid phosphodiester bond hydrolysis|DNA recombinase complex|endodeoxyribonuclease complex|double-stranded DNA endodeoxyribonuclease activity|regulation of behavioral fear response "hsa04068,hsa05340" FoxO signaling pathway|Primary immunodeficiency RAI1 1099.148691 1225.607554 972.6898275 0.793638897 -0.333445359 0.171404703 1 6.847615428 5.343594392 10743 retinoic acid induced 1 "GO:0001501,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0032922,GO:0040015,GO:0045893,GO:0046872" "skeletal system development|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|circadian regulation of gene expression|negative regulation of multicellular organism growth|positive regulation of transcription, DNA-templated|metal ion binding" RAI14 8021.058385 8320.189819 7721.92695 0.928095046 -0.107655536 0.662799429 1 63.09979236 57.58263879 26064 retinoic acid induced 14 "GO:0001650,GO:0003779,GO:0005515,GO:0005654,GO:0005829,GO:0005856,GO:0005938,GO:0007283,GO:0030054,GO:0030154" fibrillar center|actin binding|protein binding|nucleoplasm|cytosol|cytoskeleton|cell cortex|spermatogenesis|cell junction|cell differentiation RALA 1661.204815 1573.105791 1749.30384 1.112006485 0.153165201 0.520171156 1 20.54668742 22.46571848 5898 RAS like proto-oncogene A "GO:0001843,GO:0003924,GO:0005515,GO:0005525,GO:0005886,GO:0005925,GO:0006887,GO:0006935,GO:0007049,GO:0007165,GO:0007265,GO:0009986,GO:0017022,GO:0017157,GO:0019003,GO:0030139,GO:0030659,GO:0031532,GO:0031625,GO:0031755,GO:0032154,GO:0035722,GO:0051117,GO:0051301,GO:0051491,GO:0051665,GO:0061024,GO:0070062,GO:0090543" neural tube closure|GTPase activity|protein binding|GTP binding|plasma membrane|focal adhesion|exocytosis|chemotaxis|cell cycle|signal transduction|Ras protein signal transduction|cell surface|myosin binding|regulation of exocytosis|GDP binding|endocytic vesicle|cytoplasmic vesicle membrane|actin cytoskeleton reorganization|ubiquitin protein ligase binding|Edg-2 lysophosphatidic acid receptor binding|cleavage furrow|interleukin-12-mediated signaling pathway|ATPase binding|cell division|positive regulation of filopodium assembly|membrane raft localization|membrane organization|extracellular exosome|Flemming body "hsa04014,hsa04015,hsa04072,hsa05132,hsa05200,hsa05210,hsa05212" Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|Salmonella infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer RALB 1595.040383 1286.991973 1903.088793 1.478710694 0.56433982 0.017901848 0.773499658 25.66681472 37.31868807 5899 RAS like proto-oncogene B "GO:0001928,GO:0001934,GO:0003924,GO:0005515,GO:0005525,GO:0005886,GO:0006915,GO:0007049,GO:0007165,GO:0007265,GO:0009267,GO:0019003,GO:0030496,GO:0031625,GO:0032091,GO:0032092,GO:0051117,GO:0051301,GO:0060178,GO:0070062,GO:0071360,GO:0071902,GO:2000786" regulation of exocyst assembly|positive regulation of protein phosphorylation|GTPase activity|protein binding|GTP binding|plasma membrane|apoptotic process|cell cycle|signal transduction|Ras protein signal transduction|cellular response to starvation|GDP binding|midbody|ubiquitin protein ligase binding|negative regulation of protein binding|positive regulation of protein binding|ATPase binding|cell division|regulation of exocyst localization|extracellular exosome|cellular response to exogenous dsRNA|positive regulation of protein serine/threonine kinase activity|positive regulation of autophagosome assembly "hsa04014,hsa04015,hsa04072,hsa05200,hsa05210,hsa05212" Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|Pathways in cancer|Colorectal cancer|Pancreatic cancer RALBP1 2743.281026 2729.005614 2757.556438 1.010461988 0.015015051 0.951032978 1 33.25919478 33.04478189 10928 ralA binding protein 1 "GO:0005096,GO:0005515,GO:0005829,GO:0006897,GO:0006935,GO:0007264,GO:0016020,GO:0022857,GO:0031267,GO:0042626,GO:0042910,GO:0043087,GO:0043547,GO:0051056,GO:0055085,GO:1900753,GO:1990961" GTPase activator activity|protein binding|cytosol|endocytosis|chemotaxis|small GTPase mediated signal transduction|membrane|transmembrane transporter activity|small GTPase binding|ATPase-coupled transmembrane transporter activity|xenobiotic transmembrane transporter activity|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|transmembrane transport|doxorubicin transport|xenobiotic detoxification by transmembrane export across the plasma membrane "hsa04014,hsa05200,hsa05212" Ras signaling pathway|Pathways in cancer|Pancreatic cancer RALGAPA1 1262.871067 1410.801225 1114.940909 0.790289156 -0.339547483 0.159098734 1 5.58545018 4.340256375 253959 Ral GTPase activating protein catalytic subunit alpha 1 "GO:0005096,GO:0005634,GO:0005737,GO:0046982,GO:0051056,GO:0090630" GTPase activator activity|nucleus|cytoplasm|protein heterodimerization activity|regulation of small GTPase mediated signal transduction|activation of GTPase activity RALGAPA2 964.409448 1069.545471 859.2734247 0.803400554 -0.315808638 0.200401887 1 4.461789734 3.524620847 57186 Ral GTPase activating protein catalytic subunit alpha 2 "GO:0005096,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0046982,GO:0051056,GO:0090630" GTPase activator activity|extracellular space|nucleus|cytoplasm|cytosol|plasma membrane|protein heterodimerization activity|regulation of small GTPase mediated signal transduction|activation of GTPase activity RALGAPB 3383.817358 3509.316026 3258.318691 0.92847685 -0.107062155 0.652316631 1 20.97734615 19.1510594 57148 Ral GTPase activating protein non-catalytic subunit beta "GO:0005096,GO:0005515,GO:0046982,GO:0051056,GO:0090630" GTPase activator activity|protein binding|protein heterodimerization activity|regulation of small GTPase mediated signal transduction|activation of GTPase activity RALGDS 1012.650914 1011.282294 1014.019534 1.002706702 0.00389967 0.991932208 1 12.22983852 12.05773733 5900 ral guanine nucleotide dissociation stimulator "GO:0005085,GO:0005515,GO:0005634,GO:0005829,GO:0005903,GO:0007265,GO:0030695,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|nucleus|cytosol|brush border|Ras protein signal transduction|GTPase regulator activity|regulation of catalytic activity "hsa04014,hsa04015,hsa04072,hsa05200,hsa05210,hsa05212,hsa05231" Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Choline metabolism in cancer RALGPS1 121.3377794 119.6475965 123.0279624 1.028252685 0.040194839 0.947217166 1 0.614864932 0.621656896 9649 Ral GEF with PH domain and SH3 binding motif 1 "GO:0005085,GO:0005575,GO:0005737,GO:0005886,GO:0007264,GO:0032485,GO:0035556,GO:0050790" guanyl-nucleotide exchange factor activity|cellular_component|cytoplasm|plasma membrane|small GTPase mediated signal transduction|regulation of Ral protein signal transduction|intracellular signal transduction|regulation of catalytic activity RALGPS2 1209.611814 1299.476939 1119.746689 0.861690312 -0.214758632 0.375333917 1 27.10070181 22.96164119 55103 Ral GEF with PH domain and SH3 binding motif 2 "GO:0005085,GO:0005515,GO:0005737,GO:0005886,GO:0007264,GO:0032485,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|plasma membrane|small GTPase mediated signal transduction|regulation of Ral protein signal transduction|regulation of catalytic activity RALY 4107.457124 3783.985291 4430.928957 1.170968864 0.227702715 0.339467936 1 88.92309129 102.3837607 22913 RALY heterogeneous nuclear ribonucleoprotein "GO:0000398,GO:0003712,GO:0003723,GO:0005515,GO:0005634,GO:0006355,GO:0042632,GO:0071013,GO:1903506" "mRNA splicing, via spliceosome|transcription coregulator activity|RNA binding|protein binding|nucleus|regulation of transcription, DNA-templated|cholesterol homeostasis|catalytic step 2 spliceosome|regulation of nucleic acid-templated transcription" RAMAC 354.9767059 323.5687175 386.3846943 1.194134888 0.255965811 0.394560267 1 11.03403691 12.95564376 83640 RNA guanine-7 methyltransferase activating subunit "GO:0003723,GO:0004482,GO:0005515,GO:0005634,GO:0005654,GO:0005845,GO:0006370,GO:0008047,GO:0031533,GO:0032259,GO:0036031,GO:0050790,GO:0106005" RNA binding|mRNA (guanine-N7-)-methyltransferase activity|protein binding|nucleus|nucleoplasm|mRNA cap binding complex|7-methylguanosine mRNA capping|enzyme activator activity|mRNA cap methyltransferase complex|methylation|recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex|regulation of catalytic activity|RNA 5'-cap (guanine-N7)-methylation RAMP1 96.9622807 85.31393838 108.610623 1.273070088 0.348311848 0.46933709 1 1.695103533 2.121874638 10267 receptor activity modifying protein 1 "GO:0001525,GO:0001635,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0006816,GO:0006886,GO:0007186,GO:0007189,GO:0008277,GO:0009986,GO:0015026,GO:0015031,GO:0031623,GO:0032092,GO:0032870,GO:0043235,GO:0060050,GO:0072659,GO:0097643,GO:0097647,GO:0150056,GO:1990406,GO:1990407,GO:1990408" angiogenesis|calcitonin gene-related peptide receptor activity|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|calcium ion transport|intracellular protein transport|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|cell surface|coreceptor activity|protein transport|receptor internalization|positive regulation of protein binding|cellular response to hormone stimulus|receptor complex|positive regulation of protein glycosylation|protein localization to plasma membrane|amylin receptor activity|amylin receptor signaling pathway|amylin receptor complex 1|CGRP receptor complex|calcitonin gene-related peptide binding|calcitonin gene-related peptide receptor signaling pathway hsa04270 Vascular smooth muscle contraction RAN 8093.802838 6886.499489 9301.106186 1.350629039 0.433631481 0.079402779 1 133.1593554 176.8393645 5901 "RAN, member RAS oncogene family" "GO:0000054,GO:0000055,GO:0000056,GO:0000070,GO:0000278,GO:0000287,GO:0000785,GO:0003682,GO:0003723,GO:0003924,GO:0005049,GO:0005515,GO:0005525,GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005730,GO:0005737,GO:0005814,GO:0005829,GO:0006259,GO:0006409,GO:0006606,GO:0006611,GO:0007052,GO:0010586,GO:0016020,GO:0016032,GO:0019003,GO:0030496,GO:0032092,GO:0032991,GO:0035281,GO:0042307,GO:0042470,GO:0042565,GO:0043657,GO:0045296,GO:0045540,GO:0046039,GO:0046982,GO:0051301,GO:0055037,GO:0061015,GO:0070062,GO:0070883,GO:0075733,GO:0090543,GO:1902570" ribosomal subunit export from nucleus|ribosomal large subunit export from nucleus|ribosomal small subunit export from nucleus|mitotic sister chromatid segregation|mitotic cell cycle|magnesium ion binding|chromatin|chromatin binding|RNA binding|GTPase activity|nuclear export signal receptor activity|protein binding|GTP binding|nucleus|nuclear envelope|nuclear pore|nucleoplasm|nucleolus|cytoplasm|centriole|cytosol|DNA metabolic process|tRNA export from nucleus|protein import into nucleus|protein export from nucleus|mitotic spindle organization|miRNA metabolic process|membrane|viral process|GDP binding|midbody|positive regulation of protein binding|protein-containing complex|pre-miRNA export from nucleus|positive regulation of protein import into nucleus|melanosome|RNA nuclear export complex|host cell|cadherin binding|regulation of cholesterol biosynthetic process|GTP metabolic process|protein heterodimerization activity|cell division|recycling endosome|snRNA import into nucleus|extracellular exosome|pre-miRNA binding|intracellular transport of virus|Flemming body|protein localization to nucleolus "hsa03008,hsa03013,hsa05166" Ribosome biogenesis in eukaryotes|RNA transport|Human T-cell leukemia virus 1 infection RANBP1 3174.815512 2690.510301 3659.120724 1.36000993 0.443617185 0.061374077 1 54.20445066 72.48501034 5902 RAN binding protein 1 "GO:0005092,GO:0005096,GO:0005515,GO:0005634,GO:0005635,GO:0005643,GO:0005737,GO:0005813,GO:0005829,GO:0007165,GO:0016032,GO:0043547,GO:0045296,GO:0046604,GO:0046907" GDP-dissociation inhibitor activity|GTPase activator activity|protein binding|nucleus|nuclear envelope|nuclear pore|cytoplasm|centrosome|cytosol|signal transduction|viral process|positive regulation of GTPase activity|cadherin binding|positive regulation of mitotic centrosome separation|intracellular transport "hsa05166,hsa05203" Human T-cell leukemia virus 1 infection|Viral carcinogenesis RANBP10 673.5722957 789.6741369 557.4704545 0.705949997 -0.502362095 0.051178271 1 6.531843975 4.533993796 57610 RAN binding protein 10 "GO:0000151,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007010,GO:0007166" ubiquitin ligase complex|protein binding|nucleus|cytoplasm|cytosol|cytoskeleton organization|cell surface receptor signaling pathway RANBP17 245.6332542 253.8609874 237.4055211 0.935179224 -0.096685216 0.78432933 1 1.547115944 1.422619935 64901 RAN binding protein 17 "GO:0005049,GO:0005525,GO:0005643,GO:0005737,GO:0006606,GO:0006611,GO:0051028" nuclear export signal receptor activity|GTP binding|nuclear pore|cytoplasm|protein import into nucleus|protein export from nucleus|mRNA transport RANBP2 3837.211942 4082.584075 3591.839808 0.879795674 -0.184759588 0.4374736 1 16.55748983 14.32344542 5903 RAN binding protein 2 "GO:0000413,GO:0001975,GO:0003723,GO:0003755,GO:0005096,GO:0005515,GO:0005635,GO:0005642,GO:0005643,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006110,GO:0006111,GO:0006406,GO:0006409,GO:0006457,GO:0006607,GO:0016018,GO:0016020,GO:0016032,GO:0016925,GO:0019083,GO:0019789,GO:0031267,GO:0031965,GO:0033133,GO:0042405,GO:0043231,GO:0043547,GO:0043657,GO:0044614,GO:0044615,GO:0044877,GO:0046872,GO:0051642,GO:0060964,GO:0075733,GO:1900034,GO:1990723" protein peptidyl-prolyl isomerization|response to amphetamine|RNA binding|peptidyl-prolyl cis-trans isomerase activity|GTPase activator activity|protein binding|nuclear envelope|annulate lamellae|nuclear pore|nucleoplasm|cytoplasm|mitochondrion|cytosol|regulation of glycolytic process|regulation of gluconeogenesis|mRNA export from nucleus|tRNA export from nucleus|protein folding|NLS-bearing protein import into nucleus|cyclosporin A binding|membrane|viral process|protein sumoylation|viral transcription|SUMO transferase activity|small GTPase binding|nuclear membrane|positive regulation of glucokinase activity|nuclear inclusion body|intracellular membrane-bounded organelle|positive regulation of GTPase activity|host cell|nuclear pore cytoplasmic filaments|nuclear pore nuclear basket|protein-containing complex binding|metal ion binding|centrosome localization|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat|cytoplasmic periphery of the nuclear pore complex "hsa03013,hsa05014" RNA transport|Amyotrophic lateral sclerosis RANBP3 731.6731556 712.6835096 750.6628016 1.053290544 0.07490345 0.772982893 1 11.0888073 11.48429132 8498 RAN binding protein 3 "GO:0005096,GO:0005515,GO:0005634,GO:0005643,GO:0005654,GO:0005737,GO:0006611,GO:0043547,GO:0070412" GTPase activator activity|protein binding|nucleus|nuclear pore|nucleoplasm|cytoplasm|protein export from nucleus|positive regulation of GTPase activity|R-SMAD binding hsa05166 Human T-cell leukemia virus 1 infection RANBP6 939.821942 865.6243504 1014.019534 1.171431387 0.228272456 0.356673614 1 10.0427784 11.5675641 26953 RAN binding protein 6 "GO:0005515,GO:0005634,GO:0005737,GO:0006606,GO:0008139,GO:0061608" protein binding|nucleus|cytoplasm|protein import into nucleus|nuclear localization sequence binding|nuclear import signal receptor activity RANBP9 1791.935888 1737.491184 1846.380591 1.062670481 0.087694306 0.713092699 1 27.50718218 28.74192812 10048 RAN binding protein 9 "GO:0000151,GO:0000165,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005875,GO:0005886,GO:0007010,GO:0007020,GO:0007166,GO:0007411,GO:0016604,GO:0019899,GO:0065003,GO:0070373,GO:1902993" ubiquitin ligase complex|MAPK cascade|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|microtubule associated complex|plasma membrane|cytoskeleton organization|microtubule nucleation|cell surface receptor signaling pathway|axon guidance|nuclear body|enzyme binding|protein-containing complex assembly|negative regulation of ERK1 and ERK2 cascade|positive regulation of amyloid precursor protein catabolic process RANGAP1 8784.513854 9072.409057 8496.618651 0.936533902 -0.094596875 0.70364569 1 56.39154402 51.92884552 5905 Ran GTPase activating protein 1 "GO:0000776,GO:0000777,GO:0003723,GO:0005096,GO:0005515,GO:0005635,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0016235,GO:0016925,GO:0030425,GO:0031267,GO:0031625,GO:0031965,GO:0043231,GO:0044614,GO:0045296,GO:0046826,GO:0048471,GO:0048678,GO:0072686,GO:0090630,GO:1904115,GO:1904117,GO:1990723" kinetochore|condensed chromosome kinetochore|RNA binding|GTPase activator activity|protein binding|nuclear envelope|nuclear pore|nucleoplasm|cytoplasm|cytosol|signal transduction|aggresome|protein sumoylation|dendrite|small GTPase binding|ubiquitin protein ligase binding|nuclear membrane|intracellular membrane-bounded organelle|nuclear pore cytoplasmic filaments|cadherin binding|negative regulation of protein export from nucleus|perinuclear region of cytoplasm|response to axon injury|mitotic spindle|activation of GTPase activity|axon cytoplasm|cellular response to vasopressin|cytoplasmic periphery of the nuclear pore complex hsa03013 RNA transport RANGRF 398.8326048 415.1251392 382.5400705 0.921505431 -0.117935426 0.689597889 1 26.66000687 24.15623995 29098 RAN guanine nucleotide release factor "GO:0002027,GO:0003254,GO:0005085,GO:0005634,GO:0005654,GO:0005737,GO:0005791,GO:0005829,GO:0005886,GO:0005901,GO:0006888,GO:0014704,GO:0017080,GO:0031267,GO:0032527,GO:0042391,GO:0044325,GO:0048471,GO:0050790,GO:0090226,GO:0098905,GO:0098909,GO:1900825,GO:1902305,GO:1903078,GO:2000010,GO:2000649" regulation of heart rate|regulation of membrane depolarization|guanyl-nucleotide exchange factor activity|nucleus|nucleoplasm|cytoplasm|rough endoplasmic reticulum|cytosol|plasma membrane|caveola|endoplasmic reticulum to Golgi vesicle-mediated transport|intercalated disc|sodium channel regulator activity|small GTPase binding|protein exit from endoplasmic reticulum|regulation of membrane potential|ion channel binding|perinuclear region of cytoplasm|regulation of catalytic activity|regulation of microtubule nucleation by Ran protein signal transduction|regulation of bundle of His cell action potential|regulation of cardiac muscle cell action potential involved in regulation of contraction|regulation of membrane depolarization during cardiac muscle cell action potential|regulation of sodium ion transmembrane transport|positive regulation of protein localization to plasma membrane|positive regulation of protein localization to cell surface|regulation of sodium ion transmembrane transporter activity RAP1A 1188.388354 1095.555818 1281.220889 1.169471119 0.225856234 0.351846855 1 9.916519756 11.40302197 5906 "RAP1A, member of RAS oncogene family" "GO:0003924,GO:0005085,GO:0005515,GO:0005525,GO:0005737,GO:0005769,GO:0005770,GO:0005829,GO:0005886,GO:0007399,GO:0009743,GO:0010976,GO:0019003,GO:0030033,GO:0030054,GO:0031267,GO:0032045,GO:0032486,GO:0032966,GO:0035579,GO:0035690,GO:0038180,GO:0043005,GO:0043312,GO:0043547,GO:0044877,GO:0045335,GO:0045860,GO:0046326,GO:0048471,GO:0050796,GO:0061028,GO:0070062,GO:0070374,GO:0071320,GO:0072659,GO:0097327,GO:0097421,GO:0098696,GO:0098978,GO:1901888,GO:1905451,GO:1990090,GO:2000301,GO:2001214" GTPase activity|guanyl-nucleotide exchange factor activity|protein binding|GTP binding|cytoplasm|early endosome|late endosome|cytosol|plasma membrane|nervous system development|response to carbohydrate|positive regulation of neuron projection development|GDP binding|microvillus assembly|cell junction|small GTPase binding|guanyl-nucleotide exchange factor complex|Rap protein signal transduction|negative regulation of collagen biosynthetic process|specific granule membrane|cellular response to drug|nerve growth factor signaling pathway|neuron projection|neutrophil degranulation|positive regulation of GTPase activity|protein-containing complex binding|phagocytic vesicle|positive regulation of protein kinase activity|positive regulation of glucose import|perinuclear region of cytoplasm|regulation of insulin secretion|establishment of endothelial barrier|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|cellular response to cAMP|protein localization to plasma membrane|response to antineoplastic agent|liver regeneration|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane|glutamatergic synapse|regulation of cell junction assembly|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|cellular response to nerve growth factor stimulus|negative regulation of synaptic vesicle exocytosis|positive regulation of vasculogenesis "hsa04010,hsa04014,hsa04015,hsa04024,hsa04062,hsa04510,hsa04530,hsa04611,hsa04670,hsa04720,hsa04722,hsa04934,hsa04972,hsa05211" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Focal adhesion|Tight junction|Platelet activation|Leukocyte transendothelial migration|Long-term potentiation|Neurotrophin signaling pathway|Cushing syndrome|Pancreatic secretion|Renal cell carcinoma RAP1B 3964.701541 3644.569831 4284.833252 1.175675992 0.233490519 0.326829645 1 14.53909354 16.80723062 5908 "RAP1B, member of RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005811,GO:0005829,GO:0005886,GO:0005911,GO:0008283,GO:0009743,GO:0016020,GO:0019003,GO:0030033,GO:0032486,GO:0033625,GO:0035577,GO:0035690,GO:0035722,GO:0043312,GO:0044877,GO:0045121,GO:0045955,GO:0061028,GO:0070062,GO:0070374,GO:0071320,GO:0097211,GO:1901888,GO:2000114,GO:2000301" GTPase activity|protein binding|GTP binding|lipid droplet|cytosol|plasma membrane|cell-cell junction|cell population proliferation|response to carbohydrate|membrane|GDP binding|microvillus assembly|Rap protein signal transduction|positive regulation of integrin activation|azurophil granule membrane|cellular response to drug|interleukin-12-mediated signaling pathway|neutrophil degranulation|protein-containing complex binding|membrane raft|negative regulation of calcium ion-dependent exocytosis|establishment of endothelial barrier|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|cellular response to cAMP|cellular response to gonadotropin-releasing hormone|regulation of cell junction assembly|regulation of establishment of cell polarity|negative regulation of synaptic vesicle exocytosis "hsa04010,hsa04014,hsa04015,hsa04024,hsa04062,hsa04510,hsa04611,hsa04670,hsa04720,hsa04722,hsa04934,hsa04972,hsa05211" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Focal adhesion|Platelet activation|Leukocyte transendothelial migration|Long-term potentiation|Neurotrophin signaling pathway|Cushing syndrome|Pancreatic secretion|Renal cell carcinoma RAP1GAP 4.964295633 4.161655531 5.766935736 1.385731158 0.470647391 0.897151737 1 0.046493596 0.063349515 5909 RAP1 GTPase activating protein "GO:0000139,GO:0003924,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0007165,GO:0007411,GO:0016020,GO:0031267,GO:0042803,GO:0043087,GO:0043547,GO:0051056,GO:0090630,GO:1903697" Golgi membrane|GTPase activity|GTPase activator activity|protein binding|cytoplasm|cytosol|signal transduction|axon guidance|membrane|small GTPase binding|protein homodimerization activity|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|activation of GTPase activity|negative regulation of microvillus assembly hsa04015 Rap1 signaling pathway RAP1GAP2 1409.407721 1409.760811 1409.054631 0.999499079 -0.000722858 1 1 8.911091253 8.757587147 23108 RAP1 GTPase activating protein 2 "GO:0005096,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0008361,GO:0031965,GO:0048471,GO:0051056,GO:0090630" GTPase activator activity|protein binding|cytoplasm|centrosome|cytosol|plasma membrane|regulation of cell size|nuclear membrane|perinuclear region of cytoplasm|regulation of small GTPase mediated signal transduction|activation of GTPase activity RAP1GDS1 1224.773272 1142.374443 1307.1721 1.144258879 0.194413487 0.422100467 1 15.65650345 17.61530827 5910 Rap1 GTPase-GDP dissociation stimulator 1 "GO:0005096,GO:0005515,GO:0005739,GO:0005783,GO:0005829,GO:0014829,GO:0031034,GO:0032471,GO:0043547,GO:0051561,GO:0070062" GTPase activator activity|protein binding|mitochondrion|endoplasmic reticulum|cytosol|vascular associated smooth muscle contraction|myosin filament assembly|negative regulation of endoplasmic reticulum calcium ion concentration|positive regulation of GTPase activity|positive regulation of mitochondrial calcium ion concentration|extracellular exosome RAP2A 1071.043039 1105.959957 1036.126121 0.936856813 -0.094099529 0.702758046 1 10.65398019 9.814231156 5911 "RAP2A, member of RAS oncogene family" "GO:0000287,GO:0001934,GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005886,GO:0019003,GO:0030033,GO:0030336,GO:0030496,GO:0031532,GO:0031954,GO:0032486,GO:0034613,GO:0035690,GO:0045184,GO:0045198,GO:0046328,GO:0048814,GO:0055037,GO:0055038,GO:0072659" magnesium ion binding|positive regulation of protein phosphorylation|GTPase activity|protein binding|GTP binding|cytosol|plasma membrane|GDP binding|microvillus assembly|negative regulation of cell migration|midbody|actin cytoskeleton reorganization|positive regulation of protein autophosphorylation|Rap protein signal transduction|cellular protein localization|cellular response to drug|establishment of protein localization|establishment of epithelial cell apical/basal polarity|regulation of JNK cascade|regulation of dendrite morphogenesis|recycling endosome|recycling endosome membrane|protein localization to plasma membrane RAP2B 900.9592924 905.1600779 896.7585069 0.990718138 -0.01345343 0.961695814 1 5.749432248 5.600750847 5912 "RAP2B, member of RAS oncogene family" "GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005886,GO:0005923,GO:0007165,GO:0016020,GO:0019003,GO:0019904,GO:0030033,GO:0030168,GO:0030336,GO:0031954,GO:0032486,GO:0035579,GO:0043312,GO:0044291,GO:0045121,GO:0055038,GO:0061097,GO:0070062,GO:0070527,GO:0070821,GO:0090557" GTPase activity|protein binding|GTP binding|cytosol|plasma membrane|bicellular tight junction|signal transduction|membrane|GDP binding|protein domain specific binding|microvillus assembly|platelet activation|negative regulation of cell migration|positive regulation of protein autophosphorylation|Rap protein signal transduction|specific granule membrane|neutrophil degranulation|cell-cell contact zone|membrane raft|recycling endosome membrane|regulation of protein tyrosine kinase activity|extracellular exosome|platelet aggregation|tertiary granule membrane|establishment of endothelial intestinal barrier RAP2C 1205.51494 1229.769209 1181.26067 0.960554762 -0.05806023 0.813361447 1 16.67442136 15.74867714 57826 "RAP2C, member of RAS oncogene family" "GO:0003713,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005829,GO:0005886,GO:0005923,GO:0019003,GO:0030033,GO:0030336,GO:0031954,GO:0032486,GO:0043312,GO:0044291,GO:0045893,GO:0055038,GO:0061097,GO:0070062,GO:0070821,GO:0090557" "transcription coactivator activity|GTPase activity|protein binding|GTP binding|cytoplasm|cytosol|plasma membrane|bicellular tight junction|GDP binding|microvillus assembly|negative regulation of cell migration|positive regulation of protein autophosphorylation|Rap protein signal transduction|neutrophil degranulation|cell-cell contact zone|positive regulation of transcription, DNA-templated|recycling endosome membrane|regulation of protein tyrosine kinase activity|extracellular exosome|tertiary granule membrane|establishment of endothelial intestinal barrier" hsa04530 Tight junction RAPGEF1 1669.625663 1844.653814 1494.597512 0.81023198 -0.303593066 0.201348648 1 8.800803122 7.01136966 2889 Rap guanine nucleotide exchange factor 1 "GO:0000186,GO:0001568,GO:0005085,GO:0005515,GO:0005737,GO:0005769,GO:0005829,GO:0007165,GO:0007169,GO:0007399,GO:0010976,GO:0017124,GO:0019221,GO:0030670,GO:0032486,GO:0032991,GO:0038180,GO:0043231,GO:0043547,GO:0046328,GO:0046579,GO:0046580,GO:0048008,GO:0048471,GO:0051898,GO:0061028,GO:0070373,GO:0070374,GO:0071320,GO:0090090,GO:0090630,GO:0098609,GO:1901888,GO:1905451,GO:1990090,GO:2000178" activation of MAPKK activity|blood vessel development|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|early endosome|cytosol|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|nervous system development|positive regulation of neuron projection development|SH3 domain binding|cytokine-mediated signaling pathway|phagocytic vesicle membrane|Rap protein signal transduction|protein-containing complex|nerve growth factor signaling pathway|intracellular membrane-bounded organelle|positive regulation of GTPase activity|regulation of JNK cascade|positive regulation of Ras protein signal transduction|negative regulation of Ras protein signal transduction|platelet-derived growth factor receptor signaling pathway|perinuclear region of cytoplasm|negative regulation of protein kinase B signaling|establishment of endothelial barrier|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|cellular response to cAMP|negative regulation of canonical Wnt signaling pathway|activation of GTPase activity|cell-cell adhesion|regulation of cell junction assembly|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|cellular response to nerve growth factor stimulus|negative regulation of neural precursor cell proliferation "hsa04015,hsa04510,hsa04722,hsa04910,hsa05211" Rap1 signaling pathway|Focal adhesion|Neurotrophin signaling pathway|Insulin signaling pathway|Renal cell carcinoma RAPGEF2 1244.609104 1410.801225 1078.416983 0.764400373 -0.387599612 0.108351147 1 6.7757261 5.092697857 9693 Rap guanine nucleotide exchange factor 2 "GO:0000165,GO:0001568,GO:0001764,GO:0005085,GO:0005096,GO:0005509,GO:0005515,GO:0005737,GO:0005770,GO:0005829,GO:0005886,GO:0005887,GO:0005911,GO:0005923,GO:0007186,GO:0007218,GO:0007264,GO:0008285,GO:0010976,GO:0016020,GO:0016324,GO:0019933,GO:0019992,GO:0021591,GO:0021884,GO:0030033,GO:0030139,GO:0030165,GO:0030552,GO:0030553,GO:0031175,GO:0031547,GO:0031697,GO:0032092,GO:0032486,GO:0032991,GO:0035556,GO:0038180,GO:0043005,GO:0043025,GO:0043547,GO:0043950,GO:0045202,GO:0045860,GO:0048022,GO:0048167,GO:0048471,GO:0050699,GO:0050774,GO:0061028,GO:0070300,GO:0070374,GO:0071320,GO:0071321,GO:0071880,GO:0072659,GO:0090557,GO:1901888,GO:1990090,GO:2000481,GO:2000670,GO:2001214,GO:2001224" MAPK cascade|blood vessel development|neuron migration|guanyl-nucleotide exchange factor activity|GTPase activator activity|calcium ion binding|protein binding|cytoplasm|late endosome|cytosol|plasma membrane|integral component of plasma membrane|cell-cell junction|bicellular tight junction|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|small GTPase mediated signal transduction|negative regulation of cell population proliferation|positive regulation of neuron projection development|membrane|apical plasma membrane|cAMP-mediated signaling|diacylglycerol binding|ventricular system development|forebrain neuron development|microvillus assembly|endocytic vesicle|PDZ domain binding|cAMP binding|cGMP binding|neuron projection development|brain-derived neurotrophic factor receptor signaling pathway|beta-1 adrenergic receptor binding|positive regulation of protein binding|Rap protein signal transduction|protein-containing complex|intracellular signal transduction|nerve growth factor signaling pathway|neuron projection|neuronal cell body|positive regulation of GTPase activity|positive regulation of cAMP-mediated signaling|synapse|positive regulation of protein kinase activity|negative regulation of melanin biosynthetic process|regulation of synaptic plasticity|perinuclear region of cytoplasm|WW domain binding|negative regulation of dendrite morphogenesis|establishment of endothelial barrier|phosphatidic acid binding|positive regulation of ERK1 and ERK2 cascade|cellular response to cAMP|cellular response to cGMP|adenylate cyclase-activating adrenergic receptor signaling pathway|protein localization to plasma membrane|establishment of endothelial intestinal barrier|regulation of cell junction assembly|cellular response to nerve growth factor stimulus|positive regulation of cAMP-dependent protein kinase activity|positive regulation of dendritic cell apoptotic process|positive regulation of vasculogenesis|positive regulation of neuron migration "hsa04010,hsa04015,hsa04530" MAPK signaling pathway|Rap1 signaling pathway|Tight junction RAPGEF3 601.1647656 591.9954992 610.3340321 1.030977487 0.044012829 0.87321282 1 4.003257951 4.058204568 10411 Rap guanine nucleotide exchange factor 3 "GO:0001525,GO:0005085,GO:0005515,GO:0005886,GO:0005902,GO:0007165,GO:0012505,GO:0016020,GO:0019904,GO:0019933,GO:0030027,GO:0030175,GO:0030552,GO:0030864,GO:0032486,GO:0033138,GO:0034242,GO:0043547,GO:0045766,GO:0046827,GO:0050796,GO:0051496,GO:0060143,GO:0061028,GO:0070062,GO:0071320,GO:1901985,GO:2000249,GO:2000615" angiogenesis|guanyl-nucleotide exchange factor activity|protein binding|plasma membrane|microvillus|signal transduction|endomembrane system|membrane|protein domain specific binding|cAMP-mediated signaling|lamellipodium|filopodium|cAMP binding|cortical actin cytoskeleton|Rap protein signal transduction|positive regulation of peptidyl-serine phosphorylation|negative regulation of syncytium formation by plasma membrane fusion|positive regulation of GTPase activity|positive regulation of angiogenesis|positive regulation of protein export from nucleus|regulation of insulin secretion|positive regulation of stress fiber assembly|positive regulation of syncytium formation by plasma membrane fusion|establishment of endothelial barrier|extracellular exosome|cellular response to cAMP|positive regulation of protein acetylation|regulation of actin cytoskeleton reorganization|regulation of histone H3-K9 acetylation "hsa04015,hsa04024,hsa04072,hsa04261,hsa04670,hsa04720,hsa04726" Rap1 signaling pathway|cAMP signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Leukocyte transendothelial migration|Long-term potentiation|Serotonergic synapse RAPGEF4 31.22247732 37.45489978 24.99005486 0.667203891 -0.583800393 0.426129086 1 0.335442048 0.220063111 11069 Rap guanine nucleotide exchange factor 4 "GO:0005085,GO:0005515,GO:0005829,GO:0005886,GO:0007186,GO:0007264,GO:0016020,GO:0017156,GO:0017157,GO:0019933,GO:0030073,GO:0030552,GO:0031267,GO:0050790,GO:0050796,GO:0098686,GO:0098693" guanyl-nucleotide exchange factor activity|protein binding|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|membrane|calcium-ion regulated exocytosis|regulation of exocytosis|cAMP-mediated signaling|insulin secretion|cAMP binding|small GTPase binding|regulation of catalytic activity|regulation of insulin secretion|hippocampal mossy fiber to CA3 synapse|regulation of synaptic vesicle cycle "hsa04015,hsa04024,hsa04072,hsa04261,hsa04670,hsa04911" Rap1 signaling pathway|cAMP signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Leukocyte transendothelial migration|Insulin secretion RAPGEF5 90.67010761 96.75849109 84.58172413 0.874152988 -0.194042302 0.704589379 1 0.435178058 0.374046517 9771 Rap guanine nucleotide exchange factor 5 "GO:0005085,GO:0005634,GO:0005654,GO:0007264,GO:0007399,GO:0016604,GO:0030742,GO:0050790" guanyl-nucleotide exchange factor activity|nucleus|nucleoplasm|small GTPase mediated signal transduction|nervous system development|nuclear body|GTP-dependent protein binding|regulation of catalytic activity "hsa04014,hsa04015" Ras signaling pathway|Rap1 signaling pathway RAPGEF6 752.8230027 801.1186896 704.5273157 0.879429384 -0.185360357 0.466453321 1 4.530009755 3.917159795 51735 Rap guanine nucleotide exchange factor 6 "GO:0005085,GO:0005515,GO:0005813,GO:0005829,GO:0005886,GO:0007265,GO:0016324,GO:0030033,GO:0030139,GO:0030742,GO:0031267,GO:0043087,GO:0043547,GO:0070300,GO:0072659,GO:0090557" guanyl-nucleotide exchange factor activity|protein binding|centrosome|cytosol|plasma membrane|Ras protein signal transduction|apical plasma membrane|microvillus assembly|endocytic vesicle|GTP-dependent protein binding|small GTPase binding|regulation of GTPase activity|positive regulation of GTPase activity|phosphatidic acid binding|protein localization to plasma membrane|establishment of endothelial intestinal barrier "hsa04015,hsa04530" Rap1 signaling pathway|Tight junction RAPGEFL1 62.88590365 73.86938567 51.90242162 0.702624249 -0.509174727 0.361249647 1 0.653559905 0.451522829 51195 Rap guanine nucleotide exchange factor like 1 "GO:0005085,GO:0007186,GO:0007264,GO:0007399,GO:0016020,GO:0050790" guanyl-nucleotide exchange factor activity|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|nervous system development|membrane|regulation of catalytic activity RAPH1 1682.736475 1608.479863 1756.993088 1.092331417 0.127410641 0.592902757 1 7.001762969 7.520262633 65059 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 "GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0007165,GO:0016604,GO:0030027,GO:0030175" protein binding|cytosol|cytoskeleton|plasma membrane|signal transduction|nuclear body|lamellipodium|filopodium RARA 471.5873491 546.2172884 396.9574098 0.726739007 -0.460490751 0.096348808 1 4.732242334 3.381556329 5914 retinoic acid receptor alpha "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001972,GO:0003682,GO:0003700,GO:0004879,GO:0005102,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006367,GO:0006468,GO:0007165,GO:0008134,GO:0008270,GO:0008284,GO:0009755,GO:0009986,GO:0015629,GO:0019899,GO:0019904,GO:0030154,GO:0030853,GO:0031490,GO:0032526,GO:0032689,GO:0032720,GO:0032736,GO:0032753,GO:0032754,GO:0032991,GO:0043277,GO:0043422,GO:0044323,GO:0045630,GO:0045787,GO:0045892,GO:0045893,GO:0045944,GO:0048384,GO:0051018,GO:0051099,GO:0051393,GO:0071391,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|retinoic acid binding|chromatin binding|DNA-binding transcription factor activity|nuclear receptor activity|signaling receptor binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|transcription initiation from RNA polymerase II promoter|protein phosphorylation|signal transduction|transcription factor binding|zinc ion binding|positive regulation of cell population proliferation|hormone-mediated signaling pathway|cell surface|actin cytoskeleton|enzyme binding|protein domain specific binding|cell differentiation|negative regulation of granulocyte differentiation|chromatin DNA binding|response to retinoic acid|negative regulation of interferon-gamma production|negative regulation of tumor necrosis factor production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|protein-containing complex|apoptotic cell clearance|protein kinase B binding|retinoic acid-responsive element binding|positive regulation of T-helper 2 cell differentiation|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|retinoic acid receptor signaling pathway|protein kinase A binding|positive regulation of binding|alpha-actinin binding|cellular response to estrogen stimulus|sequence-specific double-stranded DNA binding" "hsa04659,hsa04915,hsa05200,hsa05202,hsa05221" Th17 cell differentiation|Estrogen signaling pathway|Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia ThyrH_rcpt RARB 105.8605189 66.58648849 145.1345494 2.179639633 1.124089629 0.014946512 0.712638468 0.981657047 2.103854317 5915 retinoic acid receptor beta "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001657,GO:0002068,GO:0003148,GO:0003417,GO:0003677,GO:0004879,GO:0005634,GO:0005654,GO:0005737,GO:0006367,GO:0007165,GO:0008144,GO:0008270,GO:0008285,GO:0009755,GO:0021756,GO:0022008,GO:0030154,GO:0031641,GO:0032331,GO:0035116,GO:0035264,GO:0043065,GO:0043066,GO:0044877,GO:0045666,GO:0045944,GO:0046965,GO:0048048,GO:0048384,GO:0048566,GO:0055012,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|ureteric bud development|glandular epithelial cell development|outflow tract septum morphogenesis|growth plate cartilage development|DNA binding|nuclear receptor activity|nucleus|nucleoplasm|cytoplasm|transcription initiation from RNA polymerase II promoter|signal transduction|drug binding|zinc ion binding|negative regulation of cell population proliferation|hormone-mediated signaling pathway|striatum development|neurogenesis|cell differentiation|regulation of myelination|negative regulation of chondrocyte differentiation|embryonic hindlimb morphogenesis|multicellular organism growth|positive regulation of apoptotic process|negative regulation of apoptotic process|protein-containing complex binding|positive regulation of neuron differentiation|positive regulation of transcription by RNA polymerase II|retinoid X receptor binding|embryonic eye morphogenesis|retinoic acid receptor signaling pathway|embryonic digestive tract development|ventricular cardiac muscle cell differentiation|sequence-specific double-stranded DNA binding" "hsa05200,hsa05222,hsa05223,hsa05226" Pathways in cancer|Small cell lung cancer|Non-small cell lung cancer|Gastric cancer RARG 1158.766126 1062.262574 1255.269679 1.181694347 0.240856921 0.321646878 1 16.4369386 19.0984125 5916 retinoic acid receptor gamma "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001843,GO:0002068,GO:0003430,GO:0003677,GO:0003682,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006367,GO:0008270,GO:0008284,GO:0008285,GO:0008361,GO:0009755,GO:0009952,GO:0016021,GO:0030154,GO:0031076,GO:0031641,GO:0032331,GO:0032526,GO:0035116,GO:0035264,GO:0043065,GO:0043068,GO:0045637,GO:0045944,GO:0046965,GO:0048048,GO:0048384,GO:0060070,GO:0060324,GO:0060534,GO:0060740,GO:0070384,GO:0071300,GO:1990830,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|neural tube closure|glandular epithelial cell development|growth plate cartilage chondrocyte growth|DNA binding|chromatin binding|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|transcription initiation from RNA polymerase II promoter|zinc ion binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|regulation of cell size|hormone-mediated signaling pathway|anterior/posterior pattern specification|integral component of membrane|cell differentiation|embryonic camera-type eye development|regulation of myelination|negative regulation of chondrocyte differentiation|response to retinoic acid|embryonic hindlimb morphogenesis|multicellular organism growth|positive regulation of apoptotic process|positive regulation of programmed cell death|regulation of myeloid cell differentiation|positive regulation of transcription by RNA polymerase II|retinoid X receptor binding|embryonic eye morphogenesis|retinoic acid receptor signaling pathway|canonical Wnt signaling pathway|face development|trachea cartilage development|prostate gland epithelium morphogenesis|Harderian gland development|cellular response to retinoic acid|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding" ThyrH_rcpt RARRES1 8.566115259 10.40413883 6.728091692 0.64667454 -0.628888283 0.669388466 1 0.299649092 0.190532869 5918 retinoic acid receptor responder 1 "GO:0005515,GO:0005615,GO:0008191,GO:0008285,GO:0010951,GO:0016021,GO:0070062" protein binding|extracellular space|metalloendopeptidase inhibitor activity|negative regulation of cell population proliferation|negative regulation of endopeptidase activity|integral component of membrane|extracellular exosome RARS1 2212.400146 2039.21121 2385.589083 1.169858753 0.226334351 0.338577179 1 51.28602939 58.99343497 5917 arginyl-tRNA synthetase 1 "GO:0000049,GO:0004814,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006418,GO:0006420,GO:0016020,GO:0017101,GO:0034618,GO:0045296,GO:0070062" tRNA binding|arginine-tRNA ligase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|tRNA aminoacylation for protein translation|arginyl-tRNA aminoacylation|membrane|aminoacyl-tRNA synthetase multienzyme complex|arginine binding|cadherin binding|extracellular exosome hsa00970 Aminoacyl-tRNA biosynthesis RARS2 711.5140326 650.2586767 772.7693886 1.188403041 0.249024202 0.330806808 1 8.682289329 10.14540029 57038 "arginyl-tRNA synthetase 2, mitochondrial" "GO:0003723,GO:0004814,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0006418,GO:0006420,GO:0032543" RNA binding|arginine-tRNA ligase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|tRNA aminoacylation for protein translation|arginyl-tRNA aminoacylation|mitochondrial translation hsa00970 Aminoacyl-tRNA biosynthesis RASA1 1830.417339 1650.096418 2010.73826 1.218558042 0.285174971 0.228975781 1 12.86336738 15.41246389 5921 RAS p21 protein activator 1 "GO:0000165,GO:0000281,GO:0001570,GO:0001726,GO:0001784,GO:0001953,GO:0003924,GO:0005096,GO:0005102,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007162,GO:0007165,GO:0008360,GO:0019870,GO:0030833,GO:0035556,GO:0043066,GO:0043524,GO:0043547,GO:0046580,GO:0048013,GO:0048514,GO:0051020,GO:0051252" MAPK cascade|mitotic cytokinesis|vasculogenesis|ruffle|phosphotyrosine residue binding|negative regulation of cell-matrix adhesion|GTPase activity|GTPase activator activity|signaling receptor binding|protein binding|cytoplasm|cytosol|plasma membrane|negative regulation of cell adhesion|signal transduction|regulation of cell shape|potassium channel inhibitor activity|regulation of actin filament polymerization|intracellular signal transduction|negative regulation of apoptotic process|negative regulation of neuron apoptotic process|positive regulation of GTPase activity|negative regulation of Ras protein signal transduction|ephrin receptor signaling pathway|blood vessel morphogenesis|GTPase binding|regulation of RNA metabolic process "hsa04010,hsa04014,hsa04360" MAPK signaling pathway|Ras signaling pathway|Axon guidance RASA2 740.0857854 706.4410263 773.7305446 1.09525143 0.131262099 0.608515487 1 5.128752441 5.523275983 5922 RAS p21 protein activator 2 "GO:0000165,GO:0005096,GO:0005543,GO:0005829,GO:0007165,GO:0043547,GO:0046580,GO:0046872,GO:0048471" MAPK cascade|GTPase activator activity|phospholipid binding|cytosol|signal transduction|positive regulation of GTPase activity|negative regulation of Ras protein signal transduction|metal ion binding|perinuclear region of cytoplasm "hsa04010,hsa04014,hsa05203" MAPK signaling pathway|Ras signaling pathway|Viral carcinogenesis RASA3 2345.325903 2223.364467 2467.287339 1.109708901 0.150181278 0.525789693 1 22.232879 24.25917082 22821 RAS p21 protein activator 3 "GO:0000165,GO:0005096,GO:0005829,GO:0007165,GO:0015278,GO:0031235,GO:0043547,GO:0046580,GO:0046872,GO:0051209" MAPK cascade|GTPase activator activity|cytosol|signal transduction|calcium-release channel activity|intrinsic component of the cytoplasmic side of the plasma membrane|positive regulation of GTPase activity|negative regulation of Ras protein signal transduction|metal ion binding|release of sequestered calcium ion into cytosol hsa04014 Ras signaling pathway RASA4 24.49941604 24.96993318 24.0288989 0.962313304 -0.055421421 1 1 0.224797477 0.212705686 10156 RAS p21 protein activator 4 "GO:0000165,GO:0005096,GO:0005543,GO:0005829,GO:0005886,GO:0034260,GO:0043547,GO:0046580,GO:0046872,GO:0071277" MAPK cascade|GTPase activator activity|phospholipid binding|cytosol|plasma membrane|negative regulation of GTPase activity|positive regulation of GTPase activity|negative regulation of Ras protein signal transduction|metal ion binding|cellular response to calcium ion hsa04014 Ras signaling pathway RASA4B 42.19148246 47.8590386 36.52392633 0.76315629 -0.389949553 0.558234331 1 0.397966489 0.298628443 100271927 RAS p21 protein activator 4B "GO:0005096,GO:0005543,GO:0005829,GO:0005886,GO:0035556,GO:0043547,GO:0046580,GO:0046872,GO:0071277" GTPase activator activity|phospholipid binding|cytosol|plasma membrane|intracellular signal transduction|positive regulation of GTPase activity|negative regulation of Ras protein signal transduction|metal ion binding|cellular response to calcium ion hsa04014 Ras signaling pathway RASAL2 1492.62071 1626.166899 1359.074522 0.835753405 -0.258850768 0.278306656 1 5.480268919 4.503510743 9462 RAS protein activator like 2 "GO:0000165,GO:0005096,GO:0005515,GO:0005829,GO:0007165,GO:0043547" MAPK cascade|GTPase activator activity|protein binding|cytosol|signal transduction|positive regulation of GTPase activity hsa04014 Ras signaling pathway RASD1 53.32403389 49.93986637 56.7082014 1.135529699 0.183365439 0.780797833 1 1.524713319 1.702385337 51655 ras related dexamethasone induced 1 "GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005886,GO:0007165,GO:0007186,GO:0007263,GO:0016529,GO:0045892,GO:0048471" "GTPase activity|protein binding|GTP binding|nucleus|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|nitric oxide mediated signal transduction|sarcoplasmic reticulum|negative regulation of transcription, DNA-templated|perinuclear region of cytoplasm" "hsa04713,hsa04934" Circadian entrainment|Cushing syndrome RASD2 50.12353431 41.61655531 58.63051332 1.408826677 0.494494133 0.418697441 1 0.275831976 0.38209676 23551 RASD family member 2 "GO:0003924,GO:0005525,GO:0005886,GO:0007165,GO:0007626,GO:0031397,GO:0031624,GO:0031681,GO:0033235,GO:0043548,GO:0043949,GO:0051897" GTPase activity|GTP binding|plasma membrane|signal transduction|locomotory behavior|negative regulation of protein ubiquitination|ubiquitin conjugating enzyme binding|G-protein beta-subunit binding|positive regulation of protein sumoylation|phosphatidylinositol 3-kinase binding|regulation of cAMP-mediated signaling|positive regulation of protein kinase B signaling RASEF 47.43318084 59.30359131 35.56277037 0.599673133 -0.737751758 0.22928315 1 0.467907107 0.275896005 158158 RAS and EF-hand domain containing "GO:0003924,GO:0005509,GO:0005525,GO:0005829,GO:0019003,GO:0042802,GO:0048471" GTPase activity|calcium ion binding|GTP binding|cytosol|GDP binding|identical protein binding|perinuclear region of cytoplasm RASGEF1B 4.161655531 8.323311061 0 0 #NAME? 0.039277364 1 0.139334948 0 153020 RasGEF domain family member 1B "GO:0005085,GO:0005769,GO:0005770,GO:0007264,GO:0030496,GO:0050790" guanyl-nucleotide exchange factor activity|early endosome|late endosome|small GTPase mediated signal transduction|midbody|regulation of catalytic activity RASGRF1 127.1342833 145.6579436 108.610623 0.745655337 -0.423419164 0.327815965 1 0.771256746 0.565468328 5923 Ras protein specific guanine nucleotide releasing factor 1 "GO:0000165,GO:0005085,GO:0005829,GO:0005886,GO:0007165,GO:0007264,GO:0007616,GO:0008283,GO:0030426,GO:0031175,GO:0034976,GO:0035020,GO:0035023,GO:0035254,GO:0043005,GO:0043547,GO:0046578,GO:0046579,GO:0048167,GO:0048168,GO:0090630,GO:2000310" MAPK cascade|guanyl-nucleotide exchange factor activity|cytosol|plasma membrane|signal transduction|small GTPase mediated signal transduction|long-term memory|cell population proliferation|growth cone|neuron projection development|response to endoplasmic reticulum stress|regulation of Rac protein signal transduction|regulation of Rho protein signal transduction|glutamate receptor binding|neuron projection|positive regulation of GTPase activity|regulation of Ras protein signal transduction|positive regulation of Ras protein signal transduction|regulation of synaptic plasticity|regulation of neuronal synaptic plasticity|activation of GTPase activity|regulation of NMDA receptor activity "hsa04010,hsa04014,hsa04510" MAPK signaling pathway|Ras signaling pathway|Focal adhesion RASGRF2 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.01826079 0 5924 Ras protein specific guanine nucleotide releasing factor 2 "GO:0000165,GO:0005085,GO:0005516,GO:0005783,GO:0005789,GO:0005829,GO:0005886,GO:0007186,GO:0007264,GO:0034976,GO:0035023,GO:0043065,GO:0050790,GO:0051056,GO:0060291,GO:2000310" MAPK cascade|guanyl-nucleotide exchange factor activity|calmodulin binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|response to endoplasmic reticulum stress|regulation of Rho protein signal transduction|positive regulation of apoptotic process|regulation of catalytic activity|regulation of small GTPase mediated signal transduction|long-term synaptic potentiation|regulation of NMDA receptor activity "hsa04010,hsa04014" MAPK signaling pathway|Ras signaling pathway RASGRP2 9.408384325 7.282897178 11.53387147 1.583692752 0.663292469 0.627344635 1 0.126604181 0.197146993 10235 RAS guanyl releasing protein 2 "GO:0001558,GO:0005085,GO:0005509,GO:0005829,GO:0005886,GO:0007165,GO:0007265,GO:0008289,GO:0019992,GO:0032587,GO:0043005,GO:0043547,GO:0045202,GO:0071277" regulation of cell growth|guanyl-nucleotide exchange factor activity|calcium ion binding|cytosol|plasma membrane|signal transduction|Ras protein signal transduction|lipid binding|diacylglycerol binding|ruffle membrane|neuron projection|positive regulation of GTPase activity|synapse|cellular response to calcium ion "hsa04010,hsa04014,hsa04015,hsa04062,hsa04611,hsa05200" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|Platelet activation|Pathways in cancer RASGRP3 17.85561269 14.56579436 21.14543103 1.451718356 0.537761587 0.578658858 1 0.140214588 0.200145922 25780 RAS guanyl releasing protein 3 "GO:0000165,GO:0005085,GO:0005096,GO:0005509,GO:0005515,GO:0005886,GO:0005887,GO:0007264,GO:0007265,GO:0019900,GO:0019992,GO:0031267,GO:0032045,GO:0043547,GO:0048471" MAPK cascade|guanyl-nucleotide exchange factor activity|GTPase activator activity|calcium ion binding|protein binding|plasma membrane|integral component of plasma membrane|small GTPase mediated signal transduction|Ras protein signal transduction|kinase binding|diacylglycerol binding|small GTPase binding|guanyl-nucleotide exchange factor complex|positive regulation of GTPase activity|perinuclear region of cytoplasm "hsa04010,hsa04014,hsa04015,hsa04662,hsa05200" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|B cell receptor signaling pathway|Pathways in cancer RASIP1 7.084752362 9.363724944 4.80577978 0.513233762 -0.962312016 0.521952192 1 0.156212814 0.078832092 54922 Ras interacting protein 1 "GO:0001525,GO:0001570,GO:0005515,GO:0005795,GO:0005911,GO:0007165,GO:0010507,GO:0032991,GO:0033625,GO:0035024,GO:0042803,GO:0043087,GO:0048471,GO:0048754,GO:0051020,GO:1905709,GO:2000299" angiogenesis|vasculogenesis|protein binding|Golgi stack|cell-cell junction|signal transduction|negative regulation of autophagy|protein-containing complex|positive regulation of integrin activation|negative regulation of Rho protein signal transduction|protein homodimerization activity|regulation of GTPase activity|perinuclear region of cytoplasm|branching morphogenesis of an epithelial tube|GTPase binding|negative regulation of membrane permeability|negative regulation of Rho-dependent protein serine/threonine kinase activity RASL10A 15.1356911 6.242483296 24.0288989 3.849253216 1.944578579 0.050398597 1 0.122391572 0.463232663 10633 RAS like family 10 member A "GO:0003924,GO:0005525,GO:0005730,GO:0005886,GO:0007264" GTPase activity|GTP binding|nucleolus|plasma membrane|small GTPase mediated signal transduction RASL10B 4.404459729 2.080827765 6.728091692 3.233372701 1.693039812 0.389066599 1 0.025658492 0.081575186 91608 RAS like family 10 member B "GO:0003050,GO:0003924,GO:0005515,GO:0005525,GO:0005886,GO:0007165,GO:0090277" regulation of systemic arterial blood pressure by atrial natriuretic peptide|GTPase activity|protein binding|GTP binding|plasma membrane|signal transduction|positive regulation of peptide hormone secretion RASL11A 31.0243325 32.25283036 29.79583464 0.923820772 -0.11431511 0.919541619 1 0.665355345 0.604383434 387496 RAS like family 11 member A "GO:0003924,GO:0005515,GO:0005525,GO:0005730,GO:0007165,GO:0016020,GO:0045943" GTPase activity|protein binding|GTP binding|nucleolus|signal transduction|membrane|positive regulation of transcription by RNA polymerase I RASL11B 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.112855644 0.051256882 65997 RAS like family 11 member B "GO:0003924,GO:0005160,GO:0005515,GO:0005525,GO:0007165,GO:0016020,GO:0030512" GTPase activity|transforming growth factor beta receptor binding|protein binding|GTP binding|signal transduction|membrane|negative regulation of transforming growth factor beta receptor signaling pathway RASSF1 510.2122249 500.4390776 519.9853722 1.03905829 0.05527659 0.845742038 1 10.14337782 10.36319554 11186 Ras association domain family member 1 "GO:0000922,GO:0005515,GO:0005634,GO:0005737,GO:0005815,GO:0005874,GO:0007050,GO:0007165,GO:0007265,GO:0008270,GO:0015630,GO:0070507" spindle pole|protein binding|nucleus|cytoplasm|microtubule organizing center|microtubule|cell cycle arrest|signal transduction|Ras protein signal transduction|zinc ion binding|microtubule cytoskeleton|regulation of microtubule cytoskeleton organization "hsa04014,hsa04390,hsa04392,hsa05200,hsa05206,hsa05219,hsa05223" Ras signaling pathway|Hippo signaling pathway|Hippo signaling pathway - multiple species|Pathways in cancer|MicroRNAs in cancer|Bladder cancer|Non-small cell lung cancer RASSF10 8.645373186 12.48496659 4.80577978 0.384925322 -1.377349516 0.279195182 1 0.237624722 0.089937183 644943 Ras association domain family member 10 "GO:0000922,GO:0005515,GO:0005815,GO:0005829,GO:0007165,GO:0050769,GO:2000179" spindle pole|protein binding|microtubule organizing center|cytosol|signal transduction|positive regulation of neurogenesis|positive regulation of neural precursor cell proliferation RASSF2 168.0526085 172.7087045 163.3965125 0.946081513 -0.079963605 0.851311998 1 1.595213938 1.483947958 9770 Ras association domain family member 2 "GO:0000776,GO:0000777,GO:0001501,GO:0001503,GO:0004672,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0006468,GO:0007049,GO:0007165,GO:0031954,GO:0032991,GO:0033137,GO:0038168,GO:0043065,GO:0045667,GO:0045670,GO:0045860,GO:0046330,GO:0046849,GO:0048872,GO:0050821,GO:1901222,GO:1901223" kinetochore|condensed chromosome kinetochore|skeletal system development|ossification|protein kinase activity|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|plasma membrane|protein phosphorylation|cell cycle|signal transduction|positive regulation of protein autophosphorylation|protein-containing complex|negative regulation of peptidyl-serine phosphorylation|epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade|positive regulation of apoptotic process|regulation of osteoblast differentiation|regulation of osteoclast differentiation|positive regulation of protein kinase activity|positive regulation of JNK cascade|bone remodeling|homeostasis of number of cells|protein stabilization|regulation of NIK/NF-kappaB signaling|negative regulation of NIK/NF-kappaB signaling hsa04392 Hippo signaling pathway - multiple species RASSF3 738.5446719 754.3000649 722.7892789 0.958225132 -0.061563443 0.813326517 1 10.7606544 10.13858669 283349 Ras association domain family member 3 "GO:0005515,GO:0005737,GO:0005829,GO:0005874,GO:0005886,GO:0007165,GO:0042802,GO:0042981" protein binding|cytoplasm|cytosol|microtubule|plasma membrane|signal transduction|identical protein binding|regulation of apoptotic process RASSF4 303.8423258 305.8816815 301.8029702 0.986665722 -0.019366706 0.962282337 1 6.148528495 5.965026938 83937 Ras association domain family member 4 "GO:0005515,GO:0007049,GO:0007165" protein binding|cell cycle|signal transduction hsa04392 Hippo signaling pathway - multiple species RASSF5 38.95135393 38.49531366 39.4073942 1.023693288 0.033783529 1 1 0.474572451 0.477687149 83593 Ras association domain family member 5 "GO:0005515,GO:0005634,GO:0005737,GO:0005874,GO:0006915,GO:0007165,GO:0008285,GO:0031398,GO:0035556,GO:0042981,GO:0046872,GO:1900180" protein binding|nucleus|cytoplasm|microtubule|apoptotic process|signal transduction|negative regulation of cell population proliferation|positive regulation of protein ubiquitination|intracellular signal transduction|regulation of apoptotic process|metal ion binding|regulation of protein localization to nucleus "hsa04014,hsa04015,hsa04218,hsa04670,hsa05200,hsa05223" Ras signaling pathway|Rap1 signaling pathway|Cellular senescence|Leukocyte transendothelial migration|Pathways in cancer|Non-small cell lung cancer RASSF6 53.04160072 55.14193578 50.94126567 0.923820772 -0.11431511 0.876599748 1 0.207474885 0.188462277 166824 Ras association domain family member 6 "GO:0005515,GO:0006915,GO:0007165,GO:0042981" protein binding|apoptotic process|signal transduction|regulation of apoptotic process "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species RASSF7 525.4573564 433.8525891 617.0621237 1.422285217 0.508210804 0.060068494 1 13.38376606 18.71699876 8045 Ras association domain family member 7 "GO:0005515,GO:0005737,GO:0006915,GO:0007165,GO:0034451,GO:0070507" protein binding|cytoplasm|apoptotic process|signal transduction|centriolar satellite|regulation of microtubule cytoskeleton organization RASSF8 4235.096523 3968.138548 4502.054498 1.134550733 0.182121122 0.445380533 1 26.57784403 29.64932753 11228 Ras association domain family member 8 GO:0007165 signal transduction RASSF9 6.564545421 8.323311061 4.80577978 0.577387982 -0.792387015 0.636893371 1 0.076336108 0.043338007 9182 Ras association domain family member 9 "GO:0005515,GO:0005768,GO:0005829,GO:0006605,GO:0007165,GO:0012510,GO:0016197,GO:0046907,GO:0055037,GO:0070062" protein binding|endosome|cytosol|protein targeting|signal transduction|trans-Golgi network transport vesicle membrane|endosomal transport|intracellular transport|recycling endosome|extracellular exosome RAVER1 975.388514 1054.979677 895.797351 0.849113372 -0.235970902 0.338723913 1 16.16025442 13.49227091 125950 "ribonucleoprotein, PTB binding 1" "GO:0000398,GO:0003676,GO:0003723,GO:0005515,GO:0005634,GO:0005737" "mRNA splicing, via spliceosome|nucleic acid binding|RNA binding|protein binding|nucleus|cytoplasm" RAVER2 671.0807014 711.6430957 630.5183071 0.886003547 -0.17461562 0.5004814 1 8.408032782 7.324888791 55225 "ribonucleoprotein, PTB binding 2" "GO:0000398,GO:0003676,GO:0003723,GO:0005634,GO:0005737" "mRNA splicing, via spliceosome|nucleic acid binding|RNA binding|nucleus|cytoplasm" RB1 2231.043308 2087.070249 2375.016367 1.137966663 0.186458295 0.430651381 1 23.31165829 26.08398169 5925 RB transcriptional corepressor 1 "GO:0000082,GO:0000122,GO:0000785,GO:0000977,GO:0001102,GO:0001894,GO:0003180,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005819,GO:0006338,GO:0006355,GO:0006469,GO:0007050,GO:0007265,GO:0007346,GO:0008024,GO:0008134,GO:0010629,GO:0016032,GO:0016514,GO:0016605,GO:0019900,GO:0030154,GO:0030308,GO:0031134,GO:0031175,GO:0031625,GO:0034088,GO:0034349,GO:0035189,GO:0035914,GO:0042551,GO:0042802,GO:0043353,GO:0043433,GO:0043550,GO:0045445,GO:0045651,GO:0045786,GO:0045842,GO:0045879,GO:0045892,GO:0045944,GO:0048565,GO:0048667,GO:0050680,GO:0050728,GO:0051146,GO:0051219,GO:0051301,GO:0051402,GO:0061676,GO:0071459,GO:0071466,GO:0071901,GO:0071922,GO:0071930,GO:0090230,GO:0097284,GO:0097718,GO:0120163,GO:1902948,GO:1903055,GO:1904028,GO:1904761,GO:2000134,GO:2000679,GO:2001234" "G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|tissue homeostasis|aortic valve morphogenesis|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|spindle|chromatin remodeling|regulation of transcription, DNA-templated|negative regulation of protein kinase activity|cell cycle arrest|Ras protein signal transduction|regulation of mitotic cell cycle|cyclin/CDK positive transcription elongation factor complex|transcription factor binding|negative regulation of gene expression|viral process|SWI/SNF complex|PML body|kinase binding|cell differentiation|negative regulation of cell growth|sister chromatid biorientation|neuron projection development|ubiquitin protein ligase binding|maintenance of mitotic sister chromatid cohesion|glial cell apoptotic process|Rb-E2F complex|skeletal muscle cell differentiation|neuron maturation|identical protein binding|enucleate erythrocyte differentiation|negative regulation of DNA-binding transcription factor activity|regulation of lipid kinase activity|myoblast differentiation|positive regulation of macrophage differentiation|negative regulation of cell cycle|positive regulation of mitotic metaphase/anaphase transition|negative regulation of smoothened signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|digestive tract development|cell morphogenesis involved in neuron differentiation|negative regulation of epithelial cell proliferation|negative regulation of inflammatory response|striated muscle cell differentiation|phosphoprotein binding|cell division|neuron apoptotic process|importin-alpha family protein binding|protein localization to chromosome, centromeric region|cellular response to xenobiotic stimulus|negative regulation of protein serine/threonine kinase activity|regulation of cohesin loading|negative regulation of transcription involved in G1/S transition of mitotic cell cycle|regulation of centromere complex assembly|hepatocyte apoptotic process|disordered domain specific binding|negative regulation of cold-induced thermogenesis|negative regulation of tau-protein kinase activity|positive regulation of extracellular matrix organization|positive regulation of collagen fibril organization|negative regulation of myofibroblast differentiation|negative regulation of G1/S transition of mitotic cell cycle|positive regulation of transcription regulatory region DNA binding|negative regulation of apoptotic signaling pathway" "hsa01522,hsa04110,hsa04218,hsa04934,hsa05160,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05169,hsa05200,hsa05203,hsa05212,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226" Endocrine resistance|Cell cycle|Cellular senescence|Cushing syndrome|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Pancreatic cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer chromosome_remodelling_factor RB1CC1 3017.277827 3058.816815 2975.73884 0.972839833 -0.039725793 0.86801255 1 14.57400514 13.94092021 9821 RB1 inducible coiled-coil 1 "GO:0000045,GO:0000407,GO:0000421,GO:0000422,GO:0001889,GO:0001934,GO:0005515,GO:0005764,GO:0005789,GO:0005829,GO:0006914,GO:0007049,GO:0007507,GO:0016236,GO:0016241,GO:0019898,GO:0019901,GO:0030242,GO:0031965,GO:0034045,GO:0034727,GO:0045793,GO:0046330,GO:0060090,GO:0061709,GO:0061723,GO:1990316,GO:2001237" autophagosome assembly|phagophore assembly site|autophagosome membrane|autophagy of mitochondrion|liver development|positive regulation of protein phosphorylation|protein binding|lysosome|endoplasmic reticulum membrane|cytosol|autophagy|cell cycle|heart development|macroautophagy|regulation of macroautophagy|extrinsic component of membrane|protein kinase binding|autophagy of peroxisome|nuclear membrane|phagophore assembly site membrane|piecemeal microautophagy of the nucleus|positive regulation of cell size|positive regulation of JNK cascade|molecular adaptor activity|reticulophagy|glycophagy|Atg1/ULK1 kinase complex|negative regulation of extrinsic apoptotic signaling pathway "hsa04140,hsa04211,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022" Autophagy - animal|Longevity regulating pathway|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases RBAK 448.6095393 422.4080364 474.8110423 1.124057786 0.168716204 0.551486464 1 3.569211613 3.944864716 57786 RB associated KRAB zinc finger "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0008270,GO:0045892" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding|negative regulation of transcription, DNA-templated" hsa05168 Herpes simplex virus 1 infection RBAK-RBAKDN 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.203886083 0.246936462 100533952 RBAK-RBAKDN readthrough RBBP4 2471.900351 2366.941583 2576.859118 1.088687248 0.122589564 0.604809887 1 15.86926156 16.98756114 5928 "RB binding protein 4, chromatin remodeling factor" "GO:0000785,GO:0000978,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006260,GO:0006335,GO:0006336,GO:0006338,GO:0007049,GO:0008094,GO:0008285,GO:0016580,GO:0016581,GO:0016589,GO:0031492,GO:0031497,GO:0032991,GO:0033186,GO:0034080,GO:0035098,GO:0042393,GO:0042826,GO:0043044,GO:0045814,GO:0051726,GO:0060416,GO:0070317,GO:1901796" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|cytosol|DNA replication|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|chromatin remodeling|cell cycle|DNA-dependent ATPase activity|negative regulation of cell population proliferation|Sin3 complex|NuRD complex|NURF complex|nucleosomal DNA binding|chromatin assembly|protein-containing complex|CAF-1 complex|CENP-A containing nucleosome assembly|ESC/E(Z) complex|histone binding|histone deacetylase binding|ATP-dependent chromatin remodeling|negative regulation of gene expression, epigenetic|regulation of cell cycle|response to growth hormone|negative regulation of G0 to G1 transition|regulation of signal transduction by p53 class mediator" hsa04218 Cellular senescence RBBP5 801.0739149 818.8057256 783.3421041 0.956688601 -0.063878686 0.803821216 1 9.9223789 9.333780535 5929 "RB binding protein 5, histone lysine methyltransferase complex subunit" "GO:0000976,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006974,GO:0035064,GO:0035097,GO:0042800,GO:0043627,GO:0043687,GO:0044666,GO:0045652,GO:0048188,GO:0051568,GO:0071339,GO:1904837" transcription regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cellular response to DNA damage stimulus|methylated histone binding|histone methyltransferase complex|histone methyltransferase activity (H3-K4 specific)|response to estrogen|post-translational protein modification|MLL3/4 complex|regulation of megakaryocyte differentiation|Set1C/COMPASS complex|histone H3-K4 methylation|MLL1 complex|beta-catenin-TCF complex assembly hsa04934 Cushing syndrome other RBBP6 1524.517494 1580.388688 1468.646301 0.929294364 -0.105792436 0.658892907 1 11.58868365 10.58908878 5930 "RB binding protein 6, ubiquitin ligase" "GO:0000209,GO:0001701,GO:0003723,GO:0004842,GO:0005515,GO:0005694,GO:0005730,GO:0005813,GO:0005829,GO:0006260,GO:0006275,GO:0006397,GO:0006511,GO:0006974,GO:0008270,GO:0016607,GO:0019901,GO:0032991,GO:0035264,GO:0048568,GO:0061053,GO:0061630" protein polyubiquitination|in utero embryonic development|RNA binding|ubiquitin-protein transferase activity|protein binding|chromosome|nucleolus|centrosome|cytosol|DNA replication|regulation of DNA replication|mRNA processing|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|zinc ion binding|nuclear speck|protein kinase binding|protein-containing complex|multicellular organism growth|embryonic organ development|somite development|ubiquitin protein ligase activity RBBP7 5506.837489 5132.361683 5881.313295 1.145927286 0.196515502 0.415127483 1 103.3212788 116.4174312 5931 "RB binding protein 7, chromatin remodeling factor" "GO:0000122,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006260,GO:0016581,GO:0030308,GO:0034080,GO:0035098,GO:0043687,GO:0045814,GO:0048545,GO:0070317,GO:0070370,GO:1901796" "negative regulation of transcription by RNA polymerase II|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|DNA replication|NuRD complex|negative regulation of cell growth|CENP-A containing nucleosome assembly|ESC/E(Z) complex|post-translational protein modification|negative regulation of gene expression, epigenetic|response to steroid hormone|negative regulation of G0 to G1 transition|cellular heat acclimation|regulation of signal transduction by p53 class mediator" RBBP8 1141.103014 1166.303962 1115.902065 0.956784938 -0.063733416 0.796178463 1 15.39537445 14.48357475 5932 "RB binding protein 8, endonuclease" "GO:0000014,GO:0000403,GO:0000406,GO:0000724,GO:0000729,GO:0001103,GO:0003684,GO:0003690,GO:0003697,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006260,GO:0006281,GO:0006357,GO:0010792,GO:0017053,GO:0035861,GO:0042802,GO:0043231,GO:0045892,GO:0051301,GO:0051321,GO:0070317,GO:0070336,GO:0090305,GO:1901796" "single-stranded DNA endodeoxyribonuclease activity|Y-form DNA binding|double-strand/single-strand DNA junction binding|double-strand break repair via homologous recombination|DNA double-strand break processing|RNA polymerase II repressing transcription factor binding|damaged DNA binding|double-stranded DNA binding|single-stranded DNA binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|DNA replication|DNA repair|regulation of transcription by RNA polymerase II|DNA double-strand break processing involved in repair via single-strand annealing|transcription repressor complex|site of double-strand break|identical protein binding|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated|cell division|meiotic cell cycle|negative regulation of G0 to G1 transition|flap-structured DNA binding|nucleic acid phosphodiester bond hydrolysis|regulation of signal transduction by p53 class mediator" hsa03440 Homologous recombination RBBP9 905.1159175 925.9683556 884.2634795 0.954960798 -0.066486585 0.79249855 1 12.85902401 12.07437694 10741 "RB binding protein 9, serine hydrolase" "GO:0005515,GO:0005654,GO:0016787,GO:0042127" protein binding|nucleoplasm|hydrolase activity|regulation of cell population proliferation RBCK1 1790.676593 1881.0683 1700.284886 0.903893222 -0.14577574 0.539565077 1 26.17027057 23.25929361 10616 RANBP2-type and C3HC4-type zinc finger containing 1 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005829,GO:0007249,GO:0010803,GO:0016032,GO:0032088,GO:0042802,GO:0043123,GO:0043130,GO:0043161,GO:0046872,GO:0050852,GO:0051092,GO:0060546,GO:0071797,GO:0097039,GO:1901224,GO:2001238" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytosol|I-kappaB kinase/NF-kappaB signaling|regulation of tumor necrosis factor-mediated signaling pathway|viral process|negative regulation of NF-kappaB transcription factor activity|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|negative regulation of necroptotic process|LUBAC complex|protein linear polyubiquitination|positive regulation of NIK/NF-kappaB signaling|positive regulation of extrinsic apoptotic signaling pathway "hsa04217,hsa04621,hsa05131" Necroptosis|NOD-like receptor signaling pathway|Shigellosis other RBFA 529.2321688 507.7219747 550.7423628 1.084732177 0.117338881 0.668284395 1 4.847260937 5.169994734 79863 ribosome binding factor A "GO:0003674,GO:0005515,GO:0005575,GO:0005739,GO:0006364,GO:0008150" molecular_function|protein binding|cellular_component|mitochondrion|rRNA processing|biological_process RBFOX2 5212.374095 5602.628758 4822.119431 0.86068873 -0.216436517 0.368167904 1 31.08128894 26.30366808 23543 RNA binding fox-1 homolog 2 "GO:0000381,GO:0003714,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006397,GO:0007399,GO:0008134,GO:0008380,GO:0008543,GO:0010724,GO:0016070,GO:0021942,GO:0030520,GO:0042127,GO:0045892,GO:0048813,GO:0050885" "regulation of alternative mRNA splicing, via spliceosome|transcription corepressor activity|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|mRNA processing|nervous system development|transcription factor binding|RNA splicing|fibroblast growth factor receptor signaling pathway|regulation of definitive erythrocyte differentiation|RNA metabolic process|radial glia guided migration of Purkinje cell|intracellular estrogen receptor signaling pathway|regulation of cell population proliferation|negative regulation of transcription, DNA-templated|dendrite morphogenesis|neuromuscular process controlling balance" RBIS 1110.951133 1056.020091 1165.882175 1.104034085 0.142784713 0.559488727 1 32.76619266 35.569654 401466 ribosomal biogenesis factor "GO:0005654,GO:0005730,GO:0005829,GO:0042254" nucleoplasm|nucleolus|cytosol|ribosome biogenesis RBKS 54.44370569 54.1015219 54.78588949 1.012649692 0.018135186 1 1 1.220329159 1.215087077 64080 ribokinase "GO:0004747,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0006098,GO:0019303,GO:0042802,GO:0046835,GO:0046872" ribokinase activity|protein binding|ATP binding|nucleus|cytosol|pentose-phosphate shunt|D-ribose catabolic process|identical protein binding|carbohydrate phosphorylation|metal ion binding hsa00030 Pentose phosphate pathway RBL1 1007.557056 1129.889477 885.2246355 0.783461262 -0.352066152 0.151728243 1 9.713293285 7.482646157 5933 RB transcriptional corepressor like 1 "GO:0000122,GO:0000785,GO:0000977,GO:0001102,GO:0005515,GO:0005654,GO:0005667,GO:0006325,GO:0007049,GO:0008134,GO:0010629,GO:0016032,GO:0030154,GO:0043550,GO:0045944,GO:0051302,GO:1990841,GO:2000134,GO:2000773" negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|protein binding|nucleoplasm|transcription regulator complex|chromatin organization|cell cycle|transcription factor binding|negative regulation of gene expression|viral process|cell differentiation|regulation of lipid kinase activity|positive regulation of transcription by RNA polymerase II|regulation of cell division|promoter-specific chromatin binding|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of cellular senescence "hsa04110,hsa04218,hsa04350,hsa05165,hsa05203" Cell cycle|Cellular senescence|TGF-beta signaling pathway|Human papillomavirus infection|Viral carcinogenesis other RBL2 3282.04108 3146.211581 3417.87058 1.086344796 0.119482075 0.614807511 1 31.23861016 33.36803024 5934 RB transcriptional corepressor like 2 "GO:0000785,GO:0000977,GO:0001102,GO:0005515,GO:0005654,GO:0005667,GO:0005694,GO:0005730,GO:0005829,GO:0006325,GO:0006357,GO:0006977,GO:0010629,GO:0030154,GO:0043550,GO:0051302,GO:0070062,GO:1990841,GO:2000134" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|protein binding|nucleoplasm|transcription regulator complex|chromosome|nucleolus|cytosol|chromatin organization|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of gene expression|cell differentiation|regulation of lipid kinase activity|regulation of cell division|extracellular exosome|promoter-specific chromatin binding|negative regulation of G1/S transition of mitotic cell cycle" "hsa04068,hsa04110,hsa04151,hsa04218,hsa05165,hsa05203" FoxO signaling pathway|Cell cycle|PI3K-Akt signaling pathway|Cellular senescence|Human papillomavirus infection|Viral carcinogenesis other RBM10 1535.298415 1560.620824 1509.976007 0.967548288 -0.04759443 0.844211302 1 21.95241568 20.8845992 8241 RNA binding motif protein 10 "GO:0000122,GO:0000381,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0008150,GO:0008285,GO:0016607,GO:0032991,GO:0034393,GO:0035198,GO:0042802,GO:0046872,GO:0048025,GO:0070935" "negative regulation of transcription by RNA polymerase II|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|biological_process|negative regulation of cell population proliferation|nuclear speck|protein-containing complex|positive regulation of smooth muscle cell apoptotic process|miRNA binding|identical protein binding|metal ion binding|negative regulation of mRNA splicing, via spliceosome|3'-UTR-mediated mRNA stabilization" RBM11 209.6200884 178.9511878 240.288989 1.34276275 0.42520442 0.234834772 1 5.15396438 6.804745327 54033 RNA binding motif protein 11 "GO:0000381,GO:0003727,GO:0005515,GO:0005634,GO:0005654,GO:0006397,GO:0007275,GO:0008266,GO:0008380,GO:0016607,GO:0030154,GO:0034599,GO:0042803" "regulation of alternative mRNA splicing, via spliceosome|single-stranded RNA binding|protein binding|nucleus|nucleoplasm|mRNA processing|multicellular organism development|poly(U) RNA binding|RNA splicing|nuclear speck|cell differentiation|cellular response to oxidative stress|protein homodimerization activity" RBM12 2723.240175 2770.622169 2675.858181 0.965796856 -0.050208327 0.83318961 1 22.24842206 21.12789261 10137 RNA binding motif protein 12 "GO:0003723,GO:0005515,GO:0005654,GO:0043484,GO:1990904" RNA binding|protein binding|nucleoplasm|regulation of RNA splicing|ribonucleoprotein complex RBM12B 1503.18901 1537.731719 1468.646301 0.955073166 -0.066316836 0.783294363 1 9.446980038 8.871576858 389677 RNA binding motif protein 12B "GO:0003723,GO:0005515,GO:0005654,GO:0043484,GO:1990904" RNA binding|protein binding|nucleoplasm|regulation of RNA splicing|ribonucleoprotein complex RBM14 464.3792938 445.2971418 483.4614459 1.085705253 0.118632493 0.674998143 1 5.921926248 6.321878021 10432 RNA binding motif protein 14 "GO:0000398,GO:0002218,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005737,GO:0009725,GO:0016575,GO:0016607,GO:0030374,GO:0045087,GO:0045944,GO:0046600,GO:0060395,GO:0098534,GO:1990904" "mRNA splicing, via spliceosome|activation of innate immune response|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytoplasm|response to hormone|histone deacetylation|nuclear speck|nuclear receptor coactivator activity|innate immune response|positive regulation of transcription by RNA polymerase II|negative regulation of centriole replication|SMAD protein signal transduction|centriole assembly|ribonucleoprotein complex" RBM15 311.313307 350.6194785 272.0071355 0.775790144 -0.366261648 0.239500335 1 5.547559192 4.231724452 64783 RNA binding motif protein 15 "GO:0000381,GO:0000398,GO:0001510,GO:0001569,GO:0003676,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0007221,GO:0009048,GO:0016032,GO:0016607,GO:0031965,GO:0036396,GO:0038163,GO:0045638,GO:0045652,GO:0045892,GO:0048536,GO:0060412,GO:0060674" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA methylation|branching involved in blood vessel morphogenesis|nucleic acid binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|positive regulation of transcription of Notch receptor target|dosage compensation by inactivation of X chromosome|viral process|nuclear speck|nuclear membrane|RNA N6-methyladenosine methyltransferase complex|thrombopoietin-mediated signaling pathway|negative regulation of myeloid cell differentiation|regulation of megakaryocyte differentiation|negative regulation of transcription, DNA-templated|spleen development|ventricular septum morphogenesis|placenta blood vessel development" RBM15B 1499.712336 1320.285217 1679.139455 1.271800542 0.346872429 0.146149157 1 10.63725777 13.30208957 29890 RNA binding motif protein 15B "GO:0000381,GO:0000398,GO:0001510,GO:0003676,GO:0003723,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005730,GO:0006406,GO:0006913,GO:0009048,GO:0016032,GO:0016607,GO:0036396,GO:0045892" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA methylation|nucleic acid binding|RNA binding|protein binding|nucleus|nuclear envelope|nucleoplasm|nucleolus|mRNA export from nucleus|nucleocytoplasmic transport|dosage compensation by inactivation of X chromosome|viral process|nuclear speck|RNA N6-methyladenosine methyltransferase complex|negative regulation of transcription, DNA-templated" RBM17 1152.701666 1104.919543 1200.483789 1.086489778 0.119674601 0.624207379 1 15.11600238 16.14855901 84991 RNA binding motif protein 17 "GO:0000380,GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005681" "alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|spliceosomal complex" hsa03040 Spliceosome RBM18 692.1072456 708.5218541 675.6926371 0.953665202 -0.068445219 0.794468874 1 7.628103519 7.152925352 92400 RNA binding motif protein 18 "GO:0003723,GO:0005654,GO:0005829,GO:0045171" RNA binding|nucleoplasm|cytosol|intercellular bridge RBM19 738.0294954 740.7746844 735.2843063 0.992588329 -0.010732603 0.972264717 1 7.062126371 6.892484969 9904 RNA binding motif protein 19 "GO:0000398,GO:0003723,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0007275,GO:0016020,GO:0016607,GO:0040019" "mRNA splicing, via spliceosome|RNA binding|nucleoplasm|chromosome|nucleolus|cytoplasm|multicellular organism development|membrane|nuclear speck|positive regulation of embryonic development" RBM22 1182.155317 1159.021065 1205.289569 1.03992033 0.056473006 0.818843885 1 26.90509964 27.51096674 55696 RNA binding motif protein 22 "GO:0000398,GO:0000974,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0017070,GO:0033120,GO:0035690,GO:0036002,GO:0042307,GO:0045292,GO:0046827,GO:0046872,GO:0048306,GO:0071006,GO:0071007,GO:0071013" "mRNA splicing, via spliceosome|Prp19 complex|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|U6 snRNA binding|positive regulation of RNA splicing|cellular response to drug|pre-mRNA binding|positive regulation of protein import into nucleus|mRNA cis splicing, via spliceosome|positive regulation of protein export from nucleus|metal ion binding|calcium-dependent protein binding|U2-type catalytic step 1 spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome RBM23 1263.550404 1315.083148 1212.017661 0.921628159 -0.117743298 0.627149691 1 5.580754657 5.057313132 55147 RNA binding motif protein 23 "GO:0003723,GO:0005515,GO:0005634,GO:0006397,GO:0008380,GO:0016020,GO:0045893,GO:0048024" "RNA binding|protein binding|nucleus|mRNA processing|RNA splicing|membrane|positive regulation of transcription, DNA-templated|regulation of mRNA splicing, via spliceosome" RBM24 445.5027745 479.6307999 411.3747492 0.857690435 -0.221471064 0.432998151 1 7.334388042 6.185369218 221662 RNA binding motif protein 24 "GO:0000381,GO:0003197,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006397,GO:0006974,GO:0008380,GO:0010830,GO:0010831,GO:0030154,GO:0035925,GO:0043488,GO:0045663,GO:0048255,GO:0061157,GO:0061158,GO:0097157,GO:1902811,GO:1905870,GO:1990715,GO:1990825,GO:2000738,GO:2000766" "regulation of alternative mRNA splicing, via spliceosome|endocardial cushion development|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|cytosol|mRNA processing|cellular response to DNA damage stimulus|RNA splicing|regulation of myotube differentiation|positive regulation of myotube differentiation|cell differentiation|mRNA 3'-UTR AU-rich region binding|regulation of mRNA stability|positive regulation of myoblast differentiation|mRNA stabilization|mRNA destabilization|3'-UTR-mediated mRNA destabilization|pre-mRNA intronic binding|positive regulation of skeletal muscle fiber differentiation|positive regulation of 3'-UTR-mediated mRNA stabilization|mRNA CDS binding|sequence-specific mRNA binding|positive regulation of stem cell differentiation|negative regulation of cytoplasmic translation" RBM25 2205.260059 2167.182118 2243.338001 1.035140509 0.049826612 0.834745457 1 25.67336881 26.13083833 58517 RNA binding motif protein 25 "GO:0000381,GO:0003723,GO:0003729,GO:0005515,GO:0005737,GO:0006397,GO:0008380,GO:0016607,GO:0042981" "regulation of alternative mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|cytoplasm|mRNA processing|RNA splicing|nuclear speck|regulation of apoptotic process" hsa03040 Spliceosome RBM26 1546.391338 1561.661238 1531.121438 0.98044403 -0.02849282 0.907559292 1 9.402413138 9.064280051 64062 RNA binding motif protein 26 "GO:0003723,GO:0005515,GO:0005634,GO:0006397,GO:0010923,GO:0046872" RNA binding|protein binding|nucleus|mRNA processing|negative regulation of phosphatase activity|metal ion binding RBM27 1175.208959 1203.758862 1146.659056 0.952565411 -0.070109931 0.775302245 1 9.741076279 9.123740626 54439 RNA binding motif protein 27 "GO:0003723,GO:0005634,GO:0005737,GO:0006397,GO:0016607,GO:0046872" RNA binding|nucleus|cytoplasm|mRNA processing|nuclear speck|metal ion binding RBM28 817.5374834 809.4420007 825.6329662 1.020002626 0.028572866 0.914400054 1 2.766470182 2.774587733 55131 RNA binding motif protein 28 "GO:0003723,GO:0005681,GO:0005730,GO:0006397,GO:0008380" RNA binding|spliceosomal complex|nucleolus|mRNA processing|RNA splicing hsa03008 Ribosome biogenesis in eukaryotes RBM3 6533.658522 6061.45128 7005.865763 1.155806661 0.208900089 0.390737791 1 75.26489399 85.53597807 5935 RNA binding motif protein 3 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0006396,GO:0006417,GO:0015934,GO:0030425,GO:0043023,GO:0045727,GO:0048026" "RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|RNA processing|regulation of translation|large ribosomal subunit|dendrite|ribosomal large subunit binding|positive regulation of translation|positive regulation of mRNA splicing, via spliceosome" RBM33 1881.233459 1861.300436 1901.166481 1.021418383 0.030573929 0.899523765 1 9.471222668 9.512198296 155435 RNA binding motif protein 33 GO:0003723 RNA binding RBM34 700.0493583 677.3094376 722.7892789 1.067147804 0.093760009 0.718492041 1 19.25773034 20.20695408 23029 RNA binding motif protein 34 "GO:0003723,GO:0005654,GO:0005694,GO:0005730" RNA binding|nucleoplasm|chromosome|nucleolus RBM38 318.4773173 362.0640312 274.8906034 0.759232014 -0.397387269 0.198428676 1 7.361025485 5.495206436 55544 RNA binding motif protein 38 "GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005829,GO:0006397,GO:0007049,GO:0008380,GO:0010830,GO:0016032,GO:0030154,GO:0043484" RNA binding|mRNA binding|protein binding|nucleus|cytosol|mRNA processing|cell cycle|RNA splicing|regulation of myotube differentiation|viral process|cell differentiation|regulation of RNA splicing RBM39 4278.579441 4289.626438 4267.532445 0.994849436 -0.007449895 0.976174674 1 38.3530707 37.51704964 9584 RNA binding motif protein 39 "GO:0003723,GO:0005515,GO:0005654,GO:0006396,GO:0006397,GO:0008380,GO:0015630,GO:0016607,GO:0032991,GO:0034451,GO:0048024,GO:0050733" "RNA binding|protein binding|nucleoplasm|RNA processing|mRNA processing|RNA splicing|microtubule cytoskeleton|nuclear speck|protein-containing complex|centriolar satellite|regulation of mRNA splicing, via spliceosome|RS domain binding" RBM4 813.2865092 824.0077951 802.5652233 0.973977708 -0.038039343 0.884417068 1 10.64273513 10.19232936 5936 RNA binding motif protein 4 "GO:0000381,GO:0000398,GO:0002190,GO:0002192,GO:0003723,GO:0003729,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006396,GO:0008270,GO:0010494,GO:0016607,GO:0017148,GO:0030154,GO:0030332,GO:0032055,GO:0035198,GO:0035278,GO:0043153,GO:0045947,GO:0046685,GO:0046822,GO:0051149,GO:0097157,GO:0097158,GO:0097167" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|cap-independent translational initiation|IRES-dependent translational initiation of linear mRNA|RNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|RNA processing|zinc ion binding|cytoplasmic stress granule|nuclear speck|negative regulation of translation|cell differentiation|cyclin binding|negative regulation of translation in response to stress|miRNA binding|miRNA mediated inhibition of translation|entrainment of circadian clock by photoperiod|negative regulation of translational initiation|response to arsenic-containing substance|regulation of nucleocytoplasmic transport|positive regulation of muscle cell differentiation|pre-mRNA intronic binding|pre-mRNA intronic pyrimidine-rich binding|circadian regulation of translation" RBM41 721.3728124 732.4513734 710.2942515 0.969749361 -0.044316174 0.867289803 1 5.460201649 5.206421955 55285 RNA binding motif protein 41 "GO:0000398,GO:0005515,GO:0005689,GO:0030626,GO:0097157" "mRNA splicing, via spliceosome|protein binding|U12-type spliceosomal complex|U12 snRNA binding|pre-mRNA intronic binding" RBM42 954.9180041 870.8264198 1039.009588 1.193130531 0.254751885 0.302633909 1 27.46714274 32.22349345 79171 RNA binding motif protein 42 "GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0048025,GO:1990904" "RNA binding|protein binding|nucleus|cytoplasm|negative regulation of mRNA splicing, via spliceosome|ribonucleoprotein complex" RBM43 445.5625252 430.7313474 460.3937029 1.068865096 0.096079778 0.738674029 1 5.504631312 5.785252385 375287 RNA binding motif protein 43 "GO:0003723,GO:0005515" RNA binding|protein binding RBM44 79.21549406 98.83931885 59.59166927 0.602914609 -0.729974408 0.150755331 1 0.917848058 0.544123871 375316 RNA binding motif protein 44 "GO:0003723,GO:0005737,GO:0042803,GO:0045171" RNA binding|cytoplasm|protein homodimerization activity|intercellular bridge RBM45 196.1192456 190.3957405 201.8427508 1.060122197 0.084230569 0.830848866 1 4.410186953 4.597101648 129831 RNA binding motif protein 45 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007399,GO:0030154,GO:1990904" RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|nervous system development|cell differentiation|ribonucleoprotein complex RBM47 55.67723398 73.86938567 37.48508228 0.507450846 -0.978660011 0.089683289 1 0.400393393 0.199780025 54502 RNA binding motif protein 47 "GO:0002244,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0016554" hematopoietic progenitor cell differentiation|RNA binding|mRNA binding|protein binding|nucleus|cytidine to uridine editing RBM48 213.8264033 175.8299462 251.8228605 1.432195516 0.518228455 0.14400062 1 1.788056605 2.517994352 84060 RNA binding motif protein 48 "GO:0003723,GO:0005515,GO:0005654" RNA binding|protein binding|nucleoplasm RBM4B 279.8285182 268.4267817 291.2302547 1.084952302 0.117631618 0.723917842 1 5.284191809 5.637160467 83759 RNA binding motif protein 4B "GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006417,GO:0007623,GO:0008270,GO:0016607,GO:0032922,GO:0032991,GO:0043153" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleoplasm|nucleolus|cytosol|regulation of translation|circadian rhythm|zinc ion binding|nuclear speck|circadian regulation of gene expression|protein-containing complex|entrainment of circadian clock by photoperiod" RBM5 1919.00539 1944.533547 1893.477233 0.973743671 -0.038386049 0.873279059 1 33.26159663 31.84629537 10181 RNA binding motif protein 5 "GO:0000245,GO:0000381,GO:0000398,GO:0003677,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0006396,GO:0006915,GO:0008285,GO:0043065,GO:0046872" "spliceosomal complex assembly|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|DNA binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|RNA processing|apoptotic process|negative regulation of cell population proliferation|positive regulation of apoptotic process|metal ion binding" RBM6 1527.099022 1534.610477 1519.587566 0.990210603 -0.014192697 0.95551033 1 17.9171605 17.44487795 10180 RNA binding motif protein 6 "GO:0000398,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0006396" "mRNA splicing, via spliceosome|DNA binding|RNA binding|protein binding|nucleus|RNA processing" RBM7 1109.836491 1039.373469 1180.299514 1.135587495 0.183438868 0.452593024 1 15.3654991 17.15688545 10179 RNA binding motif protein 7 "GO:0000381,GO:0003723,GO:0003727,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0016076,GO:0017069,GO:0051321,GO:0071889,GO:0097157" "regulation of alternative mRNA splicing, via spliceosome|RNA binding|single-stranded RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|snRNA catabolic process|snRNA binding|meiotic cell cycle|14-3-3 protein binding|pre-mRNA intronic binding" RBM8A 1748.58449 1785.350223 1711.818758 0.958813983 -0.060677146 0.800129553 1 19.40942352 18.29861307 9939 RNA binding motif protein 8A "GO:0000184,GO:0000381,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006405,GO:0006406,GO:0006417,GO:0008380,GO:0016607,GO:0030425,GO:0031124,GO:0035145,GO:0043025,GO:0071006,GO:0071013" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|regulation of translation|RNA splicing|nuclear speck|dendrite|mRNA 3'-end processing|exon-exon junction complex|neuronal cell body|U2-type catalytic step 1 spliceosome|catalytic step 2 spliceosome" "hsa03013,hsa03015,hsa03040" RNA transport|mRNA surveillance pathway|Spliceosome RBMS1 1313.788409 1271.385765 1356.191054 1.066703035 0.093158593 0.700611385 1 15.14542892 15.88533165 5937 RNA binding motif single stranded interacting protein 1 "GO:0003690,GO:0003697,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005829,GO:0006260,GO:0006396,GO:0008143,GO:0008266,GO:1990904" double-stranded DNA binding|single-stranded DNA binding|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytosol|DNA replication|RNA processing|poly(A) binding|poly(U) RNA binding|ribonucleoprotein complex RBMS2 1816.985079 1789.511878 1844.45828 1.030704687 0.043631037 0.856098709 1 9.846681096 9.979190242 5939 RNA binding motif single stranded interacting protein 2 "GO:0003723,GO:0003730,GO:0005634,GO:0005829,GO:0006396,GO:0008143,GO:0008266,GO:1990904" RNA binding|mRNA 3'-UTR binding|nucleus|cytosol|RNA processing|poly(A) binding|poly(U) RNA binding|ribonucleoprotein complex RBMS3 209.5358001 189.3553266 229.7162735 1.213149255 0.278757058 0.43935265 1 3.393400189 4.047813497 27303 RNA binding motif single stranded interacting protein 3 "GO:0002357,GO:0003723,GO:0003730,GO:0005634,GO:0005737,GO:0005829,GO:0008143,GO:0008266,GO:0010628,GO:0010629,GO:0035925,GO:0090090,GO:1990904" defense response to tumor cell|RNA binding|mRNA 3'-UTR binding|nucleus|cytoplasm|cytosol|poly(A) binding|poly(U) RNA binding|positive regulation of gene expression|negative regulation of gene expression|mRNA 3'-UTR AU-rich region binding|negative regulation of canonical Wnt signaling pathway|ribonucleoprotein complex RBMX 4988.864976 4907.632284 5070.097668 1.033104637 0.046986383 0.845497472 1 78.98411193 80.23340597 27316 RNA binding motif protein X-linked "GO:0000381,GO:0000398,GO:0000791,GO:0000978,GO:0001649,GO:0003682,GO:0003723,GO:0003727,GO:0003729,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005681,GO:0006366,GO:0006376,GO:0006509,GO:0016020,GO:0016070,GO:0019904,GO:0032991,GO:0042802,GO:0044530,GO:0045944,GO:0048025,GO:0048026,GO:0051260,GO:0070062,GO:0071013,GO:0071347,GO:1990904" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|euchromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|osteoblast differentiation|chromatin binding|RNA binding|single-stranded RNA binding|mRNA binding|protein binding|extracellular space|nucleus|nucleoplasm|spliceosomal complex|transcription by RNA polymerase II|mRNA splice site selection|membrane protein ectodomain proteolysis|membrane|RNA metabolic process|protein domain specific binding|protein-containing complex|identical protein binding|supraspliceosomal complex|positive regulation of transcription by RNA polymerase II|negative regulation of mRNA splicing, via spliceosome|positive regulation of mRNA splicing, via spliceosome|protein homooligomerization|extracellular exosome|catalytic step 2 spliceosome|cellular response to interleukin-1|ribonucleoprotein complex" hsa03040 Spliceosome RBMX2 1083.959508 1053.939263 1113.979753 1.056967694 0.079931282 0.74621206 1 30.85397774 32.06594579 51634 RNA binding motif protein X-linked 2 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005686,GO:0071005,GO:0071011" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|U2 snRNP|U2-type precatalytic spliceosome|precatalytic spliceosome" RBMXL1 744.9903304 759.5021343 730.4785266 0.961786009 -0.056212155 0.829571001 1 8.522546889 8.0597029 494115 RBMX like 1 "GO:0003723,GO:0005681,GO:0006397,GO:0008380,GO:0048026" "RNA binding|spliceosomal complex|mRNA processing|RNA splicing|positive regulation of mRNA splicing, via spliceosome" hsa03040 Spliceosome RBP4 328.9613284 284.03299 373.8896669 1.316360001 0.396554094 0.195336782 1 11.65128259 15.0806337 5950 retinol binding protein 4 "GO:0001523,GO:0001654,GO:0002639,GO:0005515,GO:0005576,GO:0005615,GO:0005829,GO:0006094,GO:0007507,GO:0007601,GO:0016918,GO:0019841,GO:0030277,GO:0030324,GO:0032024,GO:0032526,GO:0032991,GO:0034632,GO:0034633,GO:0042572,GO:0042593,GO:0044877,GO:0045471,GO:0048562,GO:0048706,GO:0048738,GO:0048807,GO:0060044,GO:0060059,GO:0060065,GO:0060068,GO:0060157,GO:0060347,GO:0070062" retinoid metabolic process|eye development|positive regulation of immunoglobulin production|protein binding|extracellular region|extracellular space|cytosol|gluconeogenesis|heart development|visual perception|retinal binding|retinol binding|maintenance of gastrointestinal epithelium|lung development|positive regulation of insulin secretion|response to retinoic acid|protein-containing complex|retinol transmembrane transporter activity|retinol transport|retinol metabolic process|glucose homeostasis|protein-containing complex binding|response to ethanol|embryonic organ morphogenesis|embryonic skeletal system development|cardiac muscle tissue development|female genitalia morphogenesis|negative regulation of cardiac muscle cell proliferation|embryonic retina morphogenesis in camera-type eye|uterus development|vagina development|urinary bladder development|heart trabecula formation|extracellular exosome RBP5 9.448013289 8.323311061 10.57271552 1.270253561 0.345116509 0.853432744 1 0.302176744 0.377418024 83758 retinol binding protein 5 "GO:0005501,GO:0005515,GO:0005737,GO:0016918,GO:0019841,GO:0070062" retinoid binding|protein binding|cytoplasm|retinal binding|retinol binding|extracellular exosome RBP7 66.22038136 47.8590386 84.58172413 1.767309302 0.821554553 0.130322701 1 4.086638286 7.101497548 116362 retinol binding protein 7 "GO:0005515,GO:0005737,GO:0016918,GO:0019841" protein binding|cytoplasm|retinal binding|retinol binding RBPJ 3045.753272 2658.25747 3433.249075 1.291541212 0.369093679 0.11918985 1 20.67118105 26.25093266 3516 recombination signal binding protein for immunoglobulin kappa J region "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001103,GO:0001228,GO:0001525,GO:0001756,GO:0001837,GO:0001974,GO:0002193,GO:0002437,GO:0003139,GO:0003151,GO:0003160,GO:0003176,GO:0003177,GO:0003198,GO:0003214,GO:0003222,GO:0003256,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006367,GO:0006959,GO:0007219,GO:0007221,GO:0008134,GO:0008285,GO:0009912,GO:0009957,GO:0010628,GO:0017053,GO:0021983,GO:0030183,GO:0030216,GO:0030279,GO:0030513,GO:0035019,GO:0035912,GO:0036302,GO:0042742,GO:0043011,GO:0043565,GO:0045596,GO:0045747,GO:0045892,GO:0045944,GO:0047485,GO:0048505,GO:0048733,GO:0048820,GO:0060045,GO:0060412,GO:0060486,GO:0060716,GO:0060844,GO:0061314,GO:0061419,GO:0070491,GO:0072554,GO:0097101,GO:0120163,GO:1901186,GO:1901189,GO:1901297,GO:2000138" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II repressing transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|somitogenesis|epithelial to mesenchymal transition|blood vessel remodeling|MAML1-RBP-Jkappa- ICN1 complex|inflammatory response to antigenic stimulus|secondary heart field specification|outflow tract morphogenesis|endocardium morphogenesis|aortic valve development|pulmonary valve development|epithelial to mesenchymal transition involved in endocardial cushion formation|cardiac left ventricle morphogenesis|ventricular trabecula myocardium morphogenesis|regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|transcription initiation from RNA polymerase II promoter|humoral immune response|Notch signaling pathway|positive regulation of transcription of Notch receptor target|transcription factor binding|negative regulation of cell population proliferation|auditory receptor cell fate commitment|epidermal cell fate specification|positive regulation of gene expression|transcription repressor complex|pituitary gland development|B cell differentiation|keratinocyte differentiation|negative regulation of ossification|positive regulation of BMP signaling pathway|somatic stem cell population maintenance|dorsal aorta morphogenesis|atrioventricular canal development|defense response to bacterium|myeloid dendritic cell differentiation|sequence-specific DNA binding|negative regulation of cell differentiation|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein N-terminus binding|regulation of timing of cell differentiation|sebaceous gland development|hair follicle maturation|positive regulation of cardiac muscle cell proliferation|ventricular septum morphogenesis|club cell differentiation|labyrinthine layer blood vessel development|arterial endothelial cell fate commitment|Notch signaling involved in heart development|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|repressing transcription factor binding|blood vessel lumenization|blood vessel endothelial cell fate specification|negative regulation of cold-induced thermogenesis|positive regulation of ERBB signaling pathway|positive regulation of ephrin receptor signaling pathway|positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment|positive regulation of cell proliferation involved in heart morphogenesis" "hsa04330,hsa04658,hsa05017,hsa05165,hsa05169,hsa05203" Notch signaling pathway|Th1 and Th2 cell differentiation|Spinocerebellar ataxia|Human papillomavirus infection|Epstein-Barr virus infection|Viral carcinogenesis TIG RBPMS 347.3270872 324.6091314 370.0450431 1.139971145 0.188997307 0.5344847 1 3.137799807 3.517144966 11030 "RNA binding protein, mRNA processing factor" "GO:0000932,GO:0003713,GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0005829,GO:0006396,GO:0006979,GO:0008143,GO:0010494,GO:0010862,GO:0042803,GO:0045893,GO:0060391" "P-body|transcription coactivator activity|RNA binding|mRNA binding|protein binding|nucleoplasm|cytosol|RNA processing|response to oxidative stress|poly(A) binding|cytoplasmic stress granule|positive regulation of pathway-restricted SMAD protein phosphorylation|protein homodimerization activity|positive regulation of transcription, DNA-templated|positive regulation of SMAD protein signal transduction" RBPMS2 286.3288969 237.2143652 335.4434286 1.414094076 0.499878102 0.118975437 1 6.27649712 8.727036963 348093 "RNA binding protein, mRNA processing factor 2" "GO:0003729,GO:0005515,GO:0005737,GO:0030514,GO:0042802,GO:0042803,GO:0048557,GO:0048661,GO:0051151" mRNA binding|protein binding|cytoplasm|negative regulation of BMP signaling pathway|identical protein binding|protein homodimerization activity|embryonic digestive tract morphogenesis|positive regulation of smooth muscle cell proliferation|negative regulation of smooth muscle cell differentiation RBSN 1005.20447 1005.039811 1005.36913 1.000327668 0.000472647 1 1 7.552397565 7.428451688 64145 "rabenosyn, RAB effector" "GO:0005515,GO:0005768,GO:0005829,GO:0005886,GO:0007596,GO:0008270,GO:0010008,GO:0015031,GO:0016197,GO:0031901,GO:0034498,GO:0043231,GO:0070062,GO:0090160,GO:1903358" protein binding|endosome|cytosol|plasma membrane|blood coagulation|zinc ion binding|endosome membrane|protein transport|endosomal transport|early endosome membrane|early endosome to Golgi transport|intracellular membrane-bounded organelle|extracellular exosome|Golgi to lysosome transport|regulation of Golgi organization hsa04144 Endocytosis RBX1 1106.676235 931.170425 1282.182045 1.376957441 0.461483969 0.058358701 1 42.51056815 57.5557351 9978 ring-box 1 "GO:0000165,GO:0000209,GO:0000715,GO:0000717,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006283,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006511,GO:0006513,GO:0008134,GO:0008270,GO:0010265,GO:0010972,GO:0016032,GO:0016055,GO:0016567,GO:0018215,GO:0019005,GO:0019788,GO:0030891,GO:0031146,GO:0031461,GO:0031462,GO:0031463,GO:0031464,GO:0031465,GO:0031466,GO:0031467,GO:0031625,GO:0032436,GO:0033683,GO:0034450,GO:0042769,GO:0043161,GO:0043687,GO:0044877,GO:0045116,GO:0061418,GO:0061630,GO:0061663,GO:0070498,GO:0070911,GO:0070936,GO:0090090,GO:0097602,GO:1902499" "MAPK cascade|protein polyubiquitination|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|ubiquitin-dependent protein catabolic process|protein monoubiquitination|transcription factor binding|zinc ion binding|SCF complex assembly|negative regulation of G2/M transition of mitotic cell cycle|viral process|Wnt signaling pathway|protein ubiquitination|protein phosphopantetheinylation|SCF ubiquitin ligase complex|NEDD8 transferase activity|VCB complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cullin-RING ubiquitin ligase complex|Cul2-RING ubiquitin ligase complex|Cul3-RING ubiquitin ligase complex|Cul4A-RING E3 ubiquitin ligase complex|Cul4B-RING E3 ubiquitin ligase complex|Cul5-RING ubiquitin ligase complex|Cul7-RING ubiquitin ligase complex|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair, DNA incision|ubiquitin-ubiquitin ligase activity|DNA damage response, detection of DNA damage|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|protein-containing complex binding|protein neddylation|regulation of transcription from RNA polymerase II promoter in response to hypoxia|ubiquitin protein ligase activity|NEDD8 ligase activity|interleukin-1-mediated signaling pathway|global genome nucleotide-excision repair|protein K48-linked ubiquitination|negative regulation of canonical Wnt signaling pathway|cullin family protein binding|positive regulation of protein autoubiquitination" "hsa03420,hsa04066,hsa04110,hsa04114,hsa04120,hsa04141,hsa04310,hsa04350,hsa04710,hsa05131,hsa05170,hsa05200,hsa05211" Nucleotide excision repair|HIF-1 signaling pathway|Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Wnt signaling pathway|TGF-beta signaling pathway|Circadian rhythm|Shigellosis|Human immunodeficiency virus 1 infection|Pathways in cancer|Renal cell carcinoma RC3H1 276.0581219 282.9925761 269.1236677 0.950991971 -0.072494934 0.833257305 1 1.325853188 1.239776689 149041 ring finger and CCCH-type domains 1 "GO:0000209,GO:0000288,GO:0000932,GO:0000956,GO:0001782,GO:0002634,GO:0002635,GO:0003723,GO:0003725,GO:0003729,GO:0003730,GO:0004842,GO:0005515,GO:0006511,GO:0008270,GO:0010494,GO:0010608,GO:0030889,GO:0033962,GO:0035198,GO:0035613,GO:0042098,GO:0043029,GO:0043488,GO:0045623,GO:0046007,GO:0048535,GO:0048536,GO:0050852,GO:0050856,GO:0061014,GO:0061158,GO:0061470,GO:0061630,GO:0071347,GO:1901224,GO:2000320,GO:2000628" "protein polyubiquitination|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|P-body|nuclear-transcribed mRNA catabolic process|B cell homeostasis|regulation of germinal center formation|negative regulation of germinal center formation|RNA binding|double-stranded RNA binding|mRNA binding|mRNA 3'-UTR binding|ubiquitin-protein transferase activity|protein binding|ubiquitin-dependent protein catabolic process|zinc ion binding|cytoplasmic stress granule|posttranscriptional regulation of gene expression|negative regulation of B cell proliferation|P-body assembly|miRNA binding|RNA stem-loop binding|T cell proliferation|T cell homeostasis|regulation of mRNA stability|negative regulation of T-helper cell differentiation|negative regulation of activated T cell proliferation|lymph node development|spleen development|T cell receptor signaling pathway|regulation of T cell receptor signaling pathway|positive regulation of mRNA catabolic process|3'-UTR-mediated mRNA destabilization|T follicular helper cell differentiation|ubiquitin protein ligase activity|cellular response to interleukin-1|positive regulation of NIK/NF-kappaB signaling|negative regulation of T-helper 17 cell differentiation|regulation of miRNA metabolic process" RC3H2 1890.89851 2026.726243 1755.070776 0.865963413 -0.207622022 0.380981783 1 10.10393785 8.603227121 54542 ring finger and CCCH-type domains 2 "GO:0000209,GO:0000288,GO:0000932,GO:0001782,GO:0003677,GO:0003723,GO:0003725,GO:0003729,GO:0006511,GO:0009791,GO:0009986,GO:0010494,GO:0016020,GO:0035264,GO:0035613,GO:0042098,GO:0043029,GO:0043231,GO:0043488,GO:0046872,GO:0048286,GO:0048535,GO:0048536,GO:0050852,GO:0060173,GO:0061470,GO:0061630,GO:1901224,GO:2000320,GO:2000628" "protein polyubiquitination|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|P-body|B cell homeostasis|DNA binding|RNA binding|double-stranded RNA binding|mRNA binding|ubiquitin-dependent protein catabolic process|post-embryonic development|cell surface|cytoplasmic stress granule|membrane|multicellular organism growth|RNA stem-loop binding|T cell proliferation|T cell homeostasis|intracellular membrane-bounded organelle|regulation of mRNA stability|metal ion binding|lung alveolus development|lymph node development|spleen development|T cell receptor signaling pathway|limb development|T follicular helper cell differentiation|ubiquitin protein ligase activity|positive regulation of NIK/NF-kappaB signaling|negative regulation of T-helper 17 cell differentiation|regulation of miRNA metabolic process" RCAN1 537.2730467 529.5706663 544.975427 1.02908915 0.041367969 0.884639292 1 4.685380164 4.74098971 1827 regulator of calcineurin 1 "GO:0003676,GO:0005515,GO:0005634,GO:0005737,GO:0008597,GO:0019722,GO:0033173,GO:0043666,GO:0070885" nucleic acid binding|protein binding|nucleus|cytoplasm|calcium-dependent protein serine/threonine phosphatase regulator activity|calcium-mediated signaling|calcineurin-NFAT signaling cascade|regulation of phosphoprotein phosphatase activity|negative regulation of calcineurin-NFAT signaling cascade "hsa04919,hsa04921,hsa05167" Thyroid hormone signaling pathway|Oxytocin signaling pathway|Kaposi sarcoma-associated herpesvirus infection RCAN3 321.9312963 238.2547791 405.6078134 1.702412077 0.767580291 0.012853653 0.668341104 4.148521915 6.94431254 11123 RCAN family member 3 "GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0008597,GO:0009653,GO:0019722,GO:0019902,GO:0031013,GO:0043666" RNA binding|protein binding|nucleus|cytoplasm|calcium-dependent protein serine/threonine phosphatase regulator activity|anatomical structure morphogenesis|calcium-mediated signaling|phosphatase binding|troponin I binding|regulation of phosphoprotein phosphatase activity RCBTB1 1138.75423 1230.809623 1046.698836 0.850414895 -0.23376123 0.336733658 1 12.35164488 10.32825218 55213 RCC1 and BTB domain containing protein 1 "GO:0005634,GO:0005737,GO:0006325,GO:0007049" nucleus|cytoplasm|chromatin organization|cell cycle RCBTB2 79.7853908 75.95021343 83.62056817 1.100991879 0.138803827 0.805712799 1 0.735630363 0.79637009 1102 RCC1 and BTB domain containing protein 2 "GO:0001669,GO:0005085,GO:0005515,GO:0050790" acrosomal vesicle|guanyl-nucleotide exchange factor activity|protein binding|regulation of catalytic activity RCC1 1411.26145 1281.789903 1540.732997 1.2020168 0.26545706 0.267734364 1 25.515394 30.15671246 1104 regulator of chromosome condensation 1 "GO:0000082,GO:0000785,GO:0000794,GO:0003682,GO:0005085,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007052,GO:0007059,GO:0007088,GO:0016032,GO:0031267,GO:0031291,GO:0031491,GO:0031492,GO:0031965,GO:0032991,GO:0042393,GO:0043199,GO:0046982,GO:0050790,GO:0051225,GO:0051301,GO:1901673" G1/S transition of mitotic cell cycle|chromatin|condensed nuclear chromosome|chromatin binding|guanyl-nucleotide exchange factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitotic spindle organization|chromosome segregation|regulation of mitotic nuclear division|viral process|small GTPase binding|Ran protein signal transduction|nucleosome binding|nucleosomal DNA binding|nuclear membrane|protein-containing complex|histone binding|sulfate binding|protein heterodimerization activity|regulation of catalytic activity|spindle assembly|cell division|regulation of mitotic spindle assembly RCC1L 773.0770892 727.249304 818.9048745 1.126030469 0.171245865 0.499977546 1 10.44455294 11.56408236 81554 RCC1 like "GO:0003723,GO:0005085,GO:0005515,GO:0005525,GO:0005743,GO:0019843,GO:0031966,GO:0050790,GO:0070131,GO:1990613" RNA binding|guanyl-nucleotide exchange factor activity|protein binding|GTP binding|mitochondrial inner membrane|rRNA binding|mitochondrial membrane|regulation of catalytic activity|positive regulation of mitochondrial translation|mitochondrial membrane fusion RCC2 1098.375004 1356.699703 840.0503055 0.619186622 -0.691553795 0.004650591 0.412966405 17.86003198 10.87364061 55920 regulator of chromosome condensation 2 "GO:0003723,GO:0005085,GO:0005515,GO:0005730,GO:0005829,GO:0005874,GO:0005886,GO:0007049,GO:0007229,GO:0008017,GO:0010762,GO:0010971,GO:0016020,GO:0019901,GO:0019904,GO:0030334,GO:0030496,GO:0031267,GO:0031901,GO:0034260,GO:0034506,GO:0045184,GO:0048041,GO:0051301,GO:0051895,GO:0051987,GO:0072356,GO:0090630,GO:1900025,GO:1900027,GO:1990023" "RNA binding|guanyl-nucleotide exchange factor activity|protein binding|nucleolus|cytosol|microtubule|plasma membrane|cell cycle|integrin-mediated signaling pathway|microtubule binding|regulation of fibroblast migration|positive regulation of G2/M transition of mitotic cell cycle|membrane|protein kinase binding|protein domain specific binding|regulation of cell migration|midbody|small GTPase binding|early endosome membrane|negative regulation of GTPase activity|chromosome, centromeric core domain|establishment of protein localization|focal adhesion assembly|cell division|negative regulation of focal adhesion assembly|positive regulation of attachment of spindle microtubules to kinetochore|chromosome passenger complex localization to kinetochore|activation of GTPase activity|negative regulation of substrate adhesion-dependent cell spreading|regulation of ruffle assembly|mitotic spindle midzone" RCCD1 411.7138611 450.4992112 372.9285109 0.827811685 -0.272625482 0.343419429 1 8.714140964 7.092956751 91433 RCC1 domain containing 1 "GO:0005515,GO:0005694,GO:0005829,GO:0005886,GO:0006325" protein binding|chromosome|cytosol|plasma membrane|chromatin organization RCE1 274.2251287 260.1034707 288.3467868 1.108584926 0.148719296 0.654370661 1 9.494695061 10.34954289 9986 Ras converting CAAX endopeptidase 1 "GO:0004175,GO:0004197,GO:0004222,GO:0005789,GO:0005829,GO:0005887,GO:0008238,GO:0016020,GO:0016579,GO:0018342,GO:0030176,GO:0071586" endopeptidase activity|cysteine-type endopeptidase activity|metalloendopeptidase activity|endoplasmic reticulum membrane|cytosol|integral component of plasma membrane|exopeptidase activity|membrane|protein deubiquitination|protein prenylation|integral component of endoplasmic reticulum membrane|CAAX-box protein processing hsa00900 Terpenoid backbone biosynthesis RCHY1 335.8133374 274.669265 396.9574098 1.445219616 0.531288742 0.080585453 1 3.276395586 4.6558755 25898 ring finger and CHY zinc finger domain containing 1 "GO:0000151,GO:0002039,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0008270,GO:0016567,GO:0016607,GO:0031398,GO:0032436,GO:0042803,GO:0043231,GO:0061630,GO:0070987" ubiquitin ligase complex|p53 binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|zinc ion binding|protein ubiquitination|nuclear speck|positive regulation of protein ubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein homodimerization activity|intracellular membrane-bounded organelle|ubiquitin protein ligase activity|error-free translesion synthesis "hsa04115,hsa04120,hsa05162" p53 signaling pathway|Ubiquitin mediated proteolysis|Measles RCL1 283.2963597 309.0029231 257.5897962 0.83361605 -0.26254504 0.417133373 1 6.780805134 5.557999586 10171 RNA terminal phosphate cyclase like 1 "GO:0000447,GO:0000479,GO:0000480,GO:0004521,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0008150" "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endoribonuclease activity|protein binding|nucleoplasm|nucleolus|rRNA processing|biological_process" hsa03008 Ribosome biogenesis in eukaryotes RCN1 4059.138359 4332.283407 3785.993311 0.873902502 -0.194455762 0.414501835 1 97.59645549 83.8625776 5954 reticulocalbin 1 "GO:0001701,GO:0005509,GO:0005515,GO:0005783,GO:0005788,GO:0043010,GO:0043687,GO:0044267" in utero embryonic development|calcium ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|camera-type eye development|post-translational protein modification|cellular protein metabolic process RCN2 1495.455717 1448.256125 1542.655309 1.065181278 0.091098976 0.704582736 1 12.32314534 12.90673145 5955 reticulocalbin 2 "GO:0005509,GO:0005515,GO:0005730,GO:0005783,GO:0005788" calcium ion binding|protein binding|nucleolus|endoplasmic reticulum|endoplasmic reticulum lumen RCN3 55.68226439 61.38441908 49.98010971 0.814214917 -0.296518441 0.624573405 1 1.634717378 1.308738604 57333 reticulocalbin 3 "GO:0005509,GO:0005515,GO:0005783,GO:0005788,GO:0009306,GO:0010952,GO:0015031,GO:0032964,GO:0036503,GO:0043129,GO:0043231,GO:0051896,GO:0055091,GO:0060428" calcium ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|protein secretion|positive regulation of peptidase activity|protein transport|collagen biosynthetic process|ERAD pathway|surfactant homeostasis|intracellular membrane-bounded organelle|regulation of protein kinase B signaling|phospholipid homeostasis|lung epithelium development RCOR1 1206.099313 1270.345351 1141.853276 0.898852643 -0.153843474 0.526297488 1 11.78855792 10.41886377 23186 REST corepressor 1 "GO:0000118,GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0007596,GO:0016032,GO:0016575,GO:0017053,GO:0019899,GO:0030218,GO:0045654,GO:0045892,GO:0070933,GO:1990391" "histone deacetylase complex|chromatin binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|blood coagulation|viral process|histone deacetylation|transcription repressor complex|enzyme binding|erythrocyte differentiation|positive regulation of megakaryocyte differentiation|negative regulation of transcription, DNA-templated|histone H4 deacetylation|DNA repair complex" hsa05016 Huntington disease MYB RCOR2 49.67755488 55.14193578 44.21317398 0.801806708 -0.318673608 0.614238206 1 1.009545031 0.795914761 283248 REST corepressor 2 "GO:0000118,GO:0003714,GO:0005515,GO:0005667,GO:0006357,GO:0016575,GO:0019899,GO:0045892" "histone deacetylase complex|transcription corepressor activity|protein binding|transcription regulator complex|regulation of transcription by RNA polymerase II|histone deacetylation|enzyme binding|negative regulation of transcription, DNA-templated" RCOR3 550.0448624 637.7737101 462.3160148 0.724890361 -0.46416529 0.08260141 1 5.761139257 4.106311358 55758 REST corepressor 3 "GO:0000118,GO:0003714,GO:0005515,GO:0005654,GO:0005667,GO:0005829,GO:0006357,GO:0016575,GO:0045892" "histone deacetylase complex|transcription corepressor activity|protein binding|nucleoplasm|transcription regulator complex|cytosol|regulation of transcription by RNA polymerase II|histone deacetylation|negative regulation of transcription, DNA-templated" RDH10 438.9382291 471.3074888 406.5689694 0.862640588 -0.213168497 0.452456582 1 6.353325196 5.38892516 157506 retinol dehydrogenase 10 "GO:0001523,GO:0001656,GO:0001701,GO:0002138,GO:0004745,GO:0005515,GO:0005634,GO:0005737,GO:0005789,GO:0005811,GO:0007601,GO:0008406,GO:0014032,GO:0016021,GO:0016616,GO:0031076,GO:0035115,GO:0042572,GO:0042574,GO:0043583,GO:0043584,GO:0048703,GO:0052650,GO:0055114,GO:0060431,GO:0060449,GO:1900054" "retinoid metabolic process|metanephros development|in utero embryonic development|retinoic acid biosynthetic process|retinol dehydrogenase activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum membrane|lipid droplet|visual perception|gonad development|neural crest cell development|integral component of membrane|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|embryonic camera-type eye development|embryonic forelimb morphogenesis|retinol metabolic process|retinal metabolic process|ear development|nose development|embryonic viscerocranium morphogenesis|NADP-retinol dehydrogenase activity|oxidation-reduction process|primary lung bud formation|bud elongation involved in lung branching|positive regulation of retinoic acid biosynthetic process" hsa00830 Retinol metabolism RDH11 1664.55377 1610.56069 1718.546849 1.067048798 0.093626155 0.69522539 1 33.85295942 35.5182942 51109 retinol dehydrogenase 11 "GO:0001523,GO:0004745,GO:0005515,GO:0005789,GO:0016021,GO:0016616,GO:0042572,GO:0042574,GO:0052650,GO:0055114,GO:0110095" "retinoid metabolic process|retinol dehydrogenase activity|protein binding|endoplasmic reticulum membrane|integral component of membrane|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|retinol metabolic process|retinal metabolic process|NADP-retinol dehydrogenase activity|oxidation-reduction process|cellular detoxification of aldehyde" hsa00830 Retinol metabolism RDH12 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.118264061 0.053713283 145226 retinol dehydrogenase 12 "GO:0001523,GO:0001917,GO:0004745,GO:0005515,GO:0005789,GO:0007601,GO:0042572,GO:0045494,GO:0052650,GO:0055114,GO:0060342,GO:0110095" retinoid metabolic process|photoreceptor inner segment|retinol dehydrogenase activity|protein binding|endoplasmic reticulum membrane|visual perception|retinol metabolic process|photoreceptor cell maintenance|NADP-retinol dehydrogenase activity|oxidation-reduction process|photoreceptor inner segment membrane|cellular detoxification of aldehyde hsa00830 Retinol metabolism RDH13 166.7247311 188.3149128 145.1345494 0.770701307 -0.375756258 0.337398309 1 2.086798336 1.581385512 112724 retinol dehydrogenase 13 "GO:0005743,GO:0009644,GO:0010842,GO:0042462,GO:0042572,GO:0042574,GO:0052650,GO:0055114" mitochondrial inner membrane|response to high light intensity|retina layer formation|eye photoreceptor cell development|retinol metabolic process|retinal metabolic process|NADP-retinol dehydrogenase activity|oxidation-reduction process RDH14 47.9584182 47.8590386 48.0577978 1.004153013 0.005979124 1 1 1.637274954 1.616563217 57665 retinol dehydrogenase 14 "GO:0001649,GO:0005634,GO:0005654,GO:0005765,GO:0005783,GO:0005789,GO:0005829,GO:0016020,GO:0016229,GO:0042572,GO:0052650,GO:0055114" osteoblast differentiation|nucleus|nucleoplasm|lysosomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|membrane|steroid dehydrogenase activity|retinol metabolic process|NADP-retinol dehydrogenase activity|oxidation-reduction process RDH5 51.35706259 61.38441908 41.32970611 0.673293105 -0.570693405 0.341642791 1 2.561355454 1.695685075 5959 retinol dehydrogenase 5 "GO:0001523,GO:0004745,GO:0005788,GO:0005789,GO:0007601,GO:0008202,GO:0016021,GO:0042572,GO:0042803,GO:0044297,GO:0047023,GO:0047044,GO:0050896,GO:0055114" "retinoid metabolic process|retinol dehydrogenase activity|endoplasmic reticulum lumen|endoplasmic reticulum membrane|visual perception|steroid metabolic process|integral component of membrane|retinol metabolic process|protein homodimerization activity|cell body|androsterone dehydrogenase activity|androstan-3-alpha,17-beta-diol dehydrogenase activity|response to stimulus|oxidation-reduction process" hsa00830 Retinol metabolism RDX 3180.091925 3510.35644 2849.82741 0.811834199 -0.300742979 0.204359884 1 34.64150729 27.65255733 5962 radixin "GO:0003723,GO:0003779,GO:0005515,GO:0005615,GO:0005886,GO:0005902,GO:0005912,GO:0005925,GO:0008360,GO:0008361,GO:0010628,GO:0010737,GO:0016324,GO:0030027,GO:0030175,GO:0030315,GO:0030335,GO:0030496,GO:0030864,GO:0032154,GO:0032231,GO:0032487,GO:0034111,GO:0034260,GO:0036120,GO:0043087,GO:0045176,GO:0045184,GO:0045296,GO:0045792,GO:0051016,GO:0051018,GO:0051117,GO:0051286,GO:0061028,GO:0070062,GO:0071944,GO:0072659,GO:0097067,GO:1900027,GO:1900087,GO:1902115,GO:1902966,GO:1903364,GO:1903392,GO:2000643" RNA binding|actin binding|protein binding|extracellular space|plasma membrane|microvillus|adherens junction|focal adhesion|regulation of cell shape|regulation of cell size|positive regulation of gene expression|protein kinase A signaling|apical plasma membrane|lamellipodium|filopodium|T-tubule|positive regulation of cell migration|midbody|cortical actin cytoskeleton|cleavage furrow|regulation of actin filament bundle assembly|regulation of Rap protein signal transduction|negative regulation of homotypic cell-cell adhesion|negative regulation of GTPase activity|cellular response to platelet-derived growth factor stimulus|regulation of GTPase activity|apical protein localization|establishment of protein localization|cadherin binding|negative regulation of cell size|barbed-end actin filament capping|protein kinase A binding|ATPase binding|cell tip|establishment of endothelial barrier|extracellular exosome|cell periphery|protein localization to plasma membrane|cellular response to thyroid hormone stimulus|regulation of ruffle assembly|positive regulation of G1/S transition of mitotic cell cycle|regulation of organelle assembly|positive regulation of protein localization to early endosome|positive regulation of cellular protein catabolic process|negative regulation of adherens junction organization|positive regulation of early endosome to late endosome transport "hsa04530,hsa04810,hsa05205,hsa05206" Tight junction|Regulation of actin cytoskeleton|Proteoglycans in cancer|MicroRNAs in cancer REC8 68.44966415 81.15228285 55.74704545 0.686943651 -0.541736334 0.314854069 1 1.697080009 1.146290281 9985 REC8 meiotic recombination protein "GO:0000778,GO:0000795,GO:0000800,GO:0001556,GO:0001673,GO:0003682,GO:0005515,GO:0005634,GO:0007062,GO:0007064,GO:0007130,GO:0007131,GO:0007141,GO:0007283,GO:0007286,GO:0009566,GO:0034990,GO:0034991,GO:0051177,GO:0051321,GO:0072520,GO:1990414" condensed nuclear chromosome kinetochore|synaptonemal complex|lateral element|oocyte maturation|male germ cell nucleus|chromatin binding|protein binding|nucleus|sister chromatid cohesion|mitotic sister chromatid cohesion|synaptonemal complex assembly|reciprocal meiotic recombination|male meiosis I|spermatogenesis|spermatid development|fertilization|nuclear mitotic cohesin complex|nuclear meiotic cohesin complex|meiotic sister chromatid cohesion|meiotic cell cycle|seminiferous tubule development|replication-born double-strand break repair via sister chromatid exchange hsa04114 Oocyte meiosis RECK 611.6928218 603.4400519 619.9455916 1.02735241 0.03893115 0.888117255 1 4.909968973 4.959859456 8434 reversion inducing cysteine rich protein with kazal motifs "GO:0001955,GO:0002040,GO:0004866,GO:0004867,GO:0005515,GO:0005576,GO:0005886,GO:0007566,GO:0008191,GO:0016020,GO:0017147,GO:0030198,GO:0030336,GO:0031225,GO:0035115,GO:0045765,GO:0060070,GO:0090210,GO:0090263,GO:1904684,GO:1904928,GO:1990909" blood vessel maturation|sprouting angiogenesis|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|plasma membrane|embryo implantation|metalloendopeptidase inhibitor activity|membrane|Wnt-protein binding|extracellular matrix organization|negative regulation of cell migration|anchored component of membrane|embryonic forelimb morphogenesis|regulation of angiogenesis|canonical Wnt signaling pathway|regulation of establishment of blood-brain barrier|positive regulation of canonical Wnt signaling pathway|negative regulation of metalloendopeptidase activity|coreceptor activity involved in canonical Wnt signaling pathway|Wnt signalosome hsa05206 MicroRNAs in cancer RECQL 4282.480629 3950.451512 4614.509745 1.168096794 0.224159827 0.34767253 1 59.42174087 68.24885685 5965 RecQ like helicase "GO:0000724,GO:0000733,GO:0003677,GO:0003678,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0006268,GO:0006281,GO:0006310,GO:0009378,GO:0016020,GO:0032508,GO:0036310,GO:0043138" double-strand break repair via homologous recombination|DNA strand renaturation|DNA binding|DNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|chromosome|cytoplasm|DNA unwinding involved in DNA replication|DNA repair|DNA recombination|four-way junction helicase activity|membrane|DNA duplex unwinding|annealing helicase activity|3'-5' DNA helicase activity RECQL4 1336.335945 1270.345351 1402.32654 1.103893944 0.142601573 0.554096703 1 17.06847849 18.52649821 9401 RecQ like helicase 4 "GO:0000405,GO:0000723,GO:0000724,GO:0000733,GO:0000781,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005694,GO:0005737,GO:0006260,GO:0006268,GO:0006281,GO:0006310,GO:0007275,GO:0009378,GO:0016020,GO:0032357,GO:0032508,GO:0036310,GO:0043138,GO:0061820,GO:0061821" "bubble DNA binding|telomere maintenance|double-strand break repair via homologous recombination|DNA strand renaturation|chromosome, telomeric region|helicase activity|protein binding|ATP binding|nucleus|chromosome|cytoplasm|DNA replication|DNA unwinding involved in DNA replication|DNA repair|DNA recombination|multicellular organism development|four-way junction helicase activity|membrane|oxidized purine DNA binding|DNA duplex unwinding|annealing helicase activity|3'-5' DNA helicase activity|telomeric D-loop disassembly|telomeric D-loop binding" RECQL5 587.5003766 611.763363 563.2373902 0.920678524 -0.1192306 0.65559429 1 4.831116648 4.373475674 9400 RecQ like helicase 5 "GO:0000278,GO:0000724,GO:0000993,GO:0003676,GO:0003678,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0006259,GO:0006260,GO:0006268,GO:0006281,GO:0006310,GO:0009378,GO:0016591,GO:0032508,GO:0034244,GO:0035690,GO:0043138,GO:0051301,GO:0051304,GO:0072757,GO:1990414,GO:2000042" "mitotic cell cycle|double-strand break repair via homologous recombination|RNA polymerase II complex binding|nucleic acid binding|DNA helicase activity|ATP binding|nucleus|nucleoplasm|chromosome|cytoplasm|cytosol|DNA metabolic process|DNA replication|DNA unwinding involved in DNA replication|DNA repair|DNA recombination|four-way junction helicase activity|RNA polymerase II, holoenzyme|DNA duplex unwinding|negative regulation of transcription elongation from RNA polymerase II promoter|cellular response to drug|3'-5' DNA helicase activity|cell division|chromosome separation|cellular response to camptothecin|replication-born double-strand break repair via sister chromatid exchange|negative regulation of double-strand break repair via homologous recombination" REEP2 778.2596514 686.6731625 869.8461402 1.26675424 0.341136658 0.176809011 1 17.19684873 21.41965227 51308 receptor accessory protein 2 "GO:0005515,GO:0005783,GO:0005789,GO:0005881,GO:0005887,GO:0008017,GO:0016020,GO:0031883,GO:0032386,GO:0032596,GO:0050913,GO:0050916,GO:0071782,GO:0071786" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytoplasmic microtubule|integral component of plasma membrane|microtubule binding|membrane|taste receptor binding|regulation of intracellular transport|protein transport into membrane raft|sensory perception of bitter taste|sensory perception of sweet taste|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network organization REEP3 2766.239328 2801.834586 2730.644071 0.974591464 -0.037130508 0.876678114 1 11.72314875 11.2340941 221035 receptor accessory protein 3 "GO:0005515,GO:0005789,GO:0005881,GO:0006998,GO:0007084,GO:0008017,GO:0016020,GO:0016021,GO:0051301,GO:0071782,GO:0071786" protein binding|endoplasmic reticulum membrane|cytoplasmic microtubule|nuclear envelope organization|mitotic nuclear envelope reassembly|microtubule binding|membrane|integral component of membrane|cell division|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network organization REEP4 594.7436448 625.2887435 564.1985462 0.90230082 -0.148319598 0.576535961 1 20.03031873 17.7709396 80346 receptor accessory protein 4 "GO:0005515,GO:0005783,GO:0005789,GO:0005881,GO:0006998,GO:0007084,GO:0008017,GO:0016020,GO:0016021,GO:0051301,GO:0071782,GO:0071786" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytoplasmic microtubule|nuclear envelope organization|mitotic nuclear envelope reassembly|microtubule binding|membrane|integral component of membrane|cell division|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network organization REEP5 3032.04361 2790.390033 3273.697186 1.173204157 0.230454088 0.330510988 1 28.21485175 32.54786788 7905 receptor accessory protein 5 "GO:0003674,GO:0005515,GO:0005783,GO:0007029,GO:0008150,GO:0016021,GO:0032386,GO:0071782" molecular_function|protein binding|endoplasmic reticulum|endoplasmic reticulum organization|biological_process|integral component of membrane|regulation of intracellular transport|endoplasmic reticulum tubular network REEP6 51.00543234 39.53572754 62.47513714 1.580219741 0.66012519 0.271567848 1 1.464225618 2.275079947 92840 receptor accessory protein 6 "GO:0001917,GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0007029,GO:0016021,GO:0030665,GO:0032386,GO:0050908" photoreceptor inner segment|protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum organization|integral component of membrane|clathrin-coated vesicle membrane|regulation of intracellular transport|detection of light stimulus involved in visual perception REL 333.2708246 422.4080364 244.1336128 0.577956837 -0.79096634 0.009508493 0.599243813 2.840975494 1.614485215 5966 "REL proto-oncogene, NF-kB subunit" "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006357,GO:0006954,GO:0007249,GO:0010629,GO:0032688,GO:0033554,GO:0034097,GO:0038061,GO:0043123,GO:0045087,GO:0045944,GO:1901215" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|regulation of transcription by RNA polymerase II|inflammatory response|I-kappaB kinase/NF-kappaB signaling|negative regulation of gene expression|negative regulation of interferon-beta production|cellular response to stress|response to cytokine|NIK/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of transcription by RNA polymerase II|negative regulation of neuron death" "hsa04014,hsa05202,hsa05203" Ras signaling pathway|Transcriptional misregulation in cancer|Viral carcinogenesis RHD RELA 2384.133218 2321.163372 2447.103064 1.054257142 0.076226796 0.748340819 1 49.21582164 51.01788734 5970 "RELA proto-oncogene, NF-kB subunit" "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000979,GO:0000981,GO:0001225,GO:0001227,GO:0001228,GO:0001889,GO:0001942,GO:0002223,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005737,GO:0005829,GO:0006117,GO:0006325,GO:0006351,GO:0006355,GO:0006357,GO:0006954,GO:0006968,GO:0007249,GO:0007568,GO:0008134,GO:0008284,GO:0009887,GO:0010033,GO:0010224,GO:0014040,GO:0016032,GO:0019221,GO:0019899,GO:0019901,GO:0031293,GO:0031490,GO:0031625,GO:0032481,GO:0032495,GO:0032570,GO:0032735,GO:0032757,GO:0032868,GO:0033209,GO:0033234,GO:0033554,GO:0033590,GO:0033613,GO:0034097,GO:0035525,GO:0035729,GO:0035924,GO:0035994,GO:0038061,GO:0038095,GO:0042177,GO:0042277,GO:0042301,GO:0042493,GO:0042802,GO:0042803,GO:0042805,GO:0042826,GO:0043066,GO:0043123,GO:0043200,GO:0043278,GO:0043620,GO:0044877,GO:0045087,GO:0045892,GO:0045893,GO:0045944,GO:0046627,GO:0047485,GO:0050727,GO:0050852,GO:0050862,GO:0051059,GO:0051092,GO:0051591,GO:0051607,GO:0070301,GO:0070431,GO:0070491,GO:0070498,GO:0070555,GO:0071222,GO:0071223,GO:0071224,GO:0071316,GO:0071347,GO:0071354,GO:0071356,GO:0071532,GO:0098978,GO:0099527,GO:1901222,GO:1901223,GO:1901224,GO:1901522,GO:1902004,GO:1902894,GO:1902895,GO:1904385,GO:1904996,GO:2000630,GO:2001237" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription coactivator binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|liver development|hair follicle development|stimulatory C-type lectin receptor signaling pathway|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytoplasm|cytosol|acetaldehyde metabolic process|chromatin organization|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|inflammatory response|cellular defense response|I-kappaB kinase/NF-kappaB signaling|aging|transcription factor binding|positive regulation of cell population proliferation|animal organ morphogenesis|response to organic substance|response to UV-B|positive regulation of Schwann cell differentiation|viral process|cytokine-mediated signaling pathway|enzyme binding|protein kinase binding|membrane protein intracellular domain proteolysis|chromatin DNA binding|ubiquitin protein ligase binding|positive regulation of type I interferon production|response to muramyl dipeptide|response to progesterone|positive regulation of interleukin-12 production|positive regulation of interleukin-8 production|response to insulin|tumor necrosis factor-mediated signaling pathway|negative regulation of protein sumoylation|cellular response to stress|response to cobalamin|activating transcription factor binding|response to cytokine|NF-kappaB p50/p65 complex|cellular response to hepatocyte growth factor stimulus|cellular response to vascular endothelial growth factor stimulus|response to muscle stretch|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|negative regulation of protein catabolic process|peptide binding|phosphate ion binding|response to drug|identical protein binding|protein homodimerization activity|actinin binding|histone deacetylase binding|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to amino acid|response to morphine|regulation of DNA-templated transcription in response to stress|protein-containing complex binding|innate immune response|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of insulin receptor signaling pathway|protein N-terminus binding|regulation of inflammatory response|T cell receptor signaling pathway|positive regulation of T cell receptor signaling pathway|NF-kappaB binding|positive regulation of NF-kappaB transcription factor activity|response to cAMP|defense response to virus|cellular response to hydrogen peroxide|nucleotide-binding oligomerization domain containing 2 signaling pathway|repressing transcription factor binding|interleukin-1-mediated signaling pathway|response to interleukin-1|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|cellular response to peptidoglycan|cellular response to nicotine|cellular response to interleukin-1|cellular response to interleukin-6|cellular response to tumor necrosis factor|ankyrin repeat binding|glutamatergic synapse|postsynapse to nucleus signaling pathway|regulation of NIK/NF-kappaB signaling|negative regulation of NIK/NF-kappaB signaling|positive regulation of NIK/NF-kappaB signaling|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|positive regulation of amyloid-beta formation|negative regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of pri-miRNA transcription by RNA polymerase II|cellular response to angiotensin|positive regulation of leukocyte adhesion to vascular endothelial cell|positive regulation of miRNA metabolic process|negative regulation of extrinsic apoptotic signaling pathway" "hsa01523,hsa04010,hsa04014,hsa04024,hsa04062,hsa04064,hsa04066,hsa04071,hsa04137,hsa04151,hsa04210,hsa04211,hsa04218,hsa04380,hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04722,hsa04917,hsa04920,hsa04926,hsa04931,hsa04932,hsa04933,hsa05010,hsa05022,hsa05030,hsa05120,hsa05130,hsa05131,hsa05132,hsa05133,hsa05134,hsa05135,hsa05140,hsa05142,hsa05145,hsa05146,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05202,hsa05203,hsa05212,hsa05215,hsa05220,hsa05221,hsa05222,hsa05235,hsa05321,hsa05418" Antifolate resistance|MAPK signaling pathway|Ras signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|HIF-1 signaling pathway|Sphingolipid signaling pathway|Mitophagy - animal|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Cellular senescence|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Prolactin signaling pathway|Adipocytokine signaling pathway|Relaxin signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Cocaine addiction|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Pancreatic cancer|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease|Fluid shear stress and atherosclerosis RHD RELB 524.9956713 585.7530159 464.2383267 0.792549614 -0.335426843 0.214763762 1 13.75299687 10.71753676 5971 "RELB proto-oncogene, NF-kB subunit" "GO:0000785,GO:0000978,GO:0000981,GO:0002223,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0006357,GO:0006954,GO:0007249,GO:0010628,GO:0017053,GO:0019882,GO:0019901,GO:0030098,GO:0032688,GO:0032922,GO:0032991,GO:0033554,GO:0034097,GO:0038061,GO:0042802,GO:0043011,GO:0045063,GO:0045087,GO:0045892,GO:0071470" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|stimulatory C-type lectin receptor signaling pathway|protein binding|nucleus|nucleoplasm|centrosome|cytosol|regulation of transcription by RNA polymerase II|inflammatory response|I-kappaB kinase/NF-kappaB signaling|positive regulation of gene expression|transcription repressor complex|antigen processing and presentation|protein kinase binding|lymphocyte differentiation|negative regulation of interferon-beta production|circadian regulation of gene expression|protein-containing complex|cellular response to stress|response to cytokine|NIK/NF-kappaB signaling|identical protein binding|myeloid dendritic cell differentiation|T-helper 1 cell differentiation|innate immune response|negative regulation of transcription, DNA-templated|cellular response to osmotic stress" "hsa04010,hsa04064,hsa04380,hsa04625,hsa05166,hsa05169" MAPK signaling pathway|NF-kappa B signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection RHD RELCH 1044.784857 1072.666713 1016.903001 0.948013944 -0.077019815 0.756123731 1 5.376749413 5.011938119 57614 "RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing" "GO:0005802,GO:0032367,GO:0055037" trans-Golgi network|intracellular cholesterol transport|recycling endosome RELL1 336.9525165 329.8112008 344.0938322 1.043305477 0.061161637 0.849651805 1 4.204829818 4.313512782 768211 RELT like 1 "GO:0005515,GO:0005886,GO:0015630,GO:0016021,GO:1900745" protein binding|plasma membrane|microtubule cytoskeleton|integral component of membrane|positive regulation of p38MAPK cascade RELL2 361.016014 343.3365813 378.6954467 1.102986012 0.141414495 0.640510156 1 8.482982554 9.200040884 285613 RELT like 2 "GO:0005515,GO:0005518,GO:0005604,GO:0005886,GO:0010811,GO:0016021,GO:1900745" protein binding|collagen binding|basement membrane|plasma membrane|positive regulation of cell-substrate adhesion|integral component of membrane|positive regulation of p38MAPK cascade RELN 21.65557714 26.01034707 17.30080721 0.665150956 -0.588246298 0.495969909 1 0.118562045 0.077542014 5649 reelin "GO:0000904,GO:0001764,GO:0005576,GO:0005615,GO:0005737,GO:0006508,GO:0007155,GO:0007411,GO:0007417,GO:0007420,GO:0008236,GO:0010001,GO:0010976,GO:0018108,GO:0021511,GO:0021766,GO:0021800,GO:0030425,GO:0032793,GO:0038026,GO:0043005,GO:0045860,GO:0046872,GO:0048265,GO:0050731,GO:0050795,GO:0050804,GO:0051057,GO:0051968,GO:0061003,GO:0061098,GO:0070325,GO:0070326,GO:0090129,GO:1900273,GO:2000310,GO:2000463,GO:2000969" "cell morphogenesis involved in differentiation|neuron migration|extracellular region|extracellular space|cytoplasm|proteolysis|cell adhesion|axon guidance|central nervous system development|brain development|serine-type peptidase activity|glial cell differentiation|positive regulation of neuron projection development|peptidyl-tyrosine phosphorylation|spinal cord patterning|hippocampus development|cerebral cortex tangential migration|dendrite|positive regulation of CREB transcription factor activity|reelin-mediated signaling pathway|neuron projection|positive regulation of protein kinase activity|metal ion binding|response to pain|positive regulation of peptidyl-tyrosine phosphorylation|regulation of behavior|modulation of chemical synaptic transmission|positive regulation of small GTPase mediated signal transduction|positive regulation of synaptic transmission, glutamatergic|positive regulation of dendritic spine morphogenesis|positive regulation of protein tyrosine kinase activity|lipoprotein particle receptor binding|very-low-density lipoprotein particle receptor binding|positive regulation of synapse maturation|positive regulation of long-term synaptic potentiation|regulation of NMDA receptor activity|positive regulation of excitatory postsynaptic potential|positive regulation of AMPA receptor activity" "hsa04151,hsa04510,hsa04512,hsa05017,hsa05165" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Spinocerebellar ataxia|Human papillomavirus infection RELT 591.6274336 606.5612936 576.6935736 0.950758942 -0.072848493 0.787699057 1 8.972023677 8.387489861 84957 RELT TNF receptor "GO:0005515,GO:0005654,GO:0005886,GO:0006915,GO:0016021,GO:0048471,GO:0097186" protein binding|nucleoplasm|plasma membrane|apoptotic process|integral component of membrane|perinuclear region of cytoplasm|amelogenesis hsa04060 Cytokine-cytokine receptor interaction REM2 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.025135798 0.068497201 161253 RRAD and GEM like GTPase 2 "GO:0003924,GO:0005246,GO:0005515,GO:0005525,GO:0005886,GO:0007165" GTPase activity|calcium channel regulator activity|protein binding|GTP binding|plasma membrane|signal transduction REN 8.367970443 5.202069413 11.53387147 2.217169852 1.148719296 0.387101353 1 0.189893901 0.413981716 5972 renin "GO:0001822,GO:0001823,GO:0002003,GO:0002018,GO:0004190,GO:0005102,GO:0005159,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005886,GO:0006508,GO:0008217,GO:0008233,GO:0008584,GO:0009755,GO:0032496,GO:0035690,GO:0035902,GO:0042756,GO:0043408,GO:0045177,GO:0048469,GO:0050435,GO:0051591,GO:0070305" kidney development|mesonephros development|angiotensin maturation|renin-angiotensin regulation of aldosterone production|aspartic-type endopeptidase activity|signaling receptor binding|insulin-like growth factor receptor binding|protein binding|extracellular region|extracellular space|cytoplasm|plasma membrane|proteolysis|regulation of blood pressure|peptidase activity|male gonad development|hormone-mediated signaling pathway|response to lipopolysaccharide|cellular response to drug|response to immobilization stress|drinking behavior|regulation of MAPK cascade|apical part of cell|cell maturation|amyloid-beta metabolic process|response to cAMP|response to cGMP "hsa04614,hsa04924" Renin-angiotensin system|Renin secretion RENBP 14.333051 10.40413883 18.26196316 1.755259466 0.811684309 0.429148346 1 0.391848812 0.676286997 5973 renin binding protein "GO:0004866,GO:0005515,GO:0005524,GO:0005829,GO:0005975,GO:0006044,GO:0006048,GO:0006051,GO:0008217,GO:0010951,GO:0019262,GO:0030414,GO:0042802,GO:0050121,GO:0070062" endopeptidase inhibitor activity|protein binding|ATP binding|cytosol|carbohydrate metabolic process|N-acetylglucosamine metabolic process|UDP-N-acetylglucosamine biosynthetic process|N-acetylmannosamine metabolic process|regulation of blood pressure|negative regulation of endopeptidase activity|N-acetylneuraminate catabolic process|peptidase inhibitor activity|identical protein binding|N-acylglucosamine 2-epimerase activity|extracellular exosome hsa00520 Amino sugar and nucleotide sugar metabolism REP15 8.407599406 6.242483296 10.57271552 1.693671415 0.760154008 0.593857288 1 0.289695531 0.482438692 387849 RAB15 effector protein "GO:0001881,GO:0005515,GO:0010008,GO:0031901,GO:0033572,GO:0048471,GO:0055037" receptor recycling|protein binding|endosome membrane|early endosome membrane|transferrin transport|perinuclear region of cytoplasm|recycling endosome REPIN1 1269.931896 1280.74949 1259.114302 0.983107401 -0.02457906 0.922165342 1 13.80833259 13.34791349 29803 replication initiator 1 "GO:0003677,GO:0003723,GO:0005654,GO:0005664,GO:0005694,GO:0006260,GO:0006357,GO:0043035,GO:0046872" DNA binding|RNA binding|nucleoplasm|nuclear origin of replication recognition complex|chromosome|DNA replication|regulation of transcription by RNA polymerase II|chromatin insulator sequence binding|metal ion binding zf-C2H2 REPS1 818.9936943 872.9072475 765.080141 0.876473581 -0.19021749 0.449792458 1 10.84139061 9.34318613 85021 RALBP1 associated Eps domain containing 1 "GO:0005509,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005905,GO:0006897,GO:0006898,GO:0016197,GO:0017124,GO:0061024" calcium ion binding|protein binding|cytoplasm|cytosol|plasma membrane|clathrin-coated pit|endocytosis|receptor-mediated endocytosis|endosomal transport|SH3 domain binding|membrane organization REPS2 357.0028135 364.1448589 349.860768 0.960773603 -0.057731582 0.855579788 1 1.992591187 1.882393637 9185 RALBP1 associated Eps domain containing 2 "GO:0005509,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0006897,GO:0007173,GO:0016197,GO:0061024,GO:0065003" calcium ion binding|protein binding|cytoplasm|cytosol|plasma membrane|endocytosis|epidermal growth factor receptor signaling pathway|endosomal transport|membrane organization|protein-containing complex assembly RER1 2750.718637 2558.377737 2943.059537 1.150361612 0.202087438 0.393097698 1 45.09112211 51.00310336 11079 retention in endoplasmic reticulum sorting receptor 1 "GO:0003674,GO:0005515,GO:0005783,GO:0005793,GO:0005794,GO:0005886,GO:0006621,GO:0006890,GO:0009986,GO:0030173,GO:0033130,GO:0071340,GO:1903078" "molecular_function|protein binding|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|plasma membrane|protein retention in ER lumen|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|cell surface|integral component of Golgi membrane|acetylcholine receptor binding|skeletal muscle acetylcholine-gated channel clustering|positive regulation of protein localization to plasma membrane" RERE 1820.090615 1934.129408 1706.051822 0.882077391 -0.181022856 0.445549939 1 12.19240866 10.57468355 473 arginine-glutamic acid dipeptide repeats "GO:0000118,GO:0001085,GO:0003682,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0006338,GO:0008270,GO:0021691,GO:0021930,GO:0021942,GO:0043565,GO:0045892,GO:0045893,GO:0048755,GO:0048813" "histone deacetylase complex|RNA polymerase II transcription factor binding|chromatin binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|chromatin remodeling|zinc ion binding|cerebellar Purkinje cell layer maturation|cerebellar granule cell precursor proliferation|radial glia guided migration of Purkinje cell|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|branching morphogenesis of a nerve|dendrite morphogenesis" RESF1 1111.807264 1217.284243 1006.330286 0.826701152 -0.274562197 0.259847316 1 9.699047889 7.884040111 55196 retroelement silencing factor 1 "GO:0000930,GO:0005515,GO:0005634,GO:0042393,GO:0045869,GO:0090309" gamma-tubulin complex|protein binding|nucleus|histone binding|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|positive regulation of DNA methylation-dependent heterochromatin assembly REST 851.7226866 848.9777282 854.4676449 1.006466503 0.009299157 0.975578841 1 5.555902023 5.498257588 5978 RE1 silencing transcription factor "GO:0000122,GO:0000381,GO:0000976,GO:0000978,GO:0001227,GO:0001666,GO:0002931,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0008134,GO:0008285,GO:0010468,GO:0010629,GO:0017053,GO:0032348,GO:0035019,GO:0035690,GO:0043065,GO:0043280,GO:0043922,GO:0045665,GO:0045666,GO:0045667,GO:0045892,GO:0045893,GO:0045944,GO:0045955,GO:0046676,GO:0046872,GO:0050768,GO:0060379,GO:0070933,GO:0071257,GO:0071385,GO:0097150,GO:0099563,GO:1902459,GO:1903203,GO:1903204,GO:1903223,GO:2000065,GO:2000706,GO:2000740,GO:2000798" "negative regulation of transcription by RNA polymerase II|regulation of alternative mRNA splicing, via spliceosome|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|response to hypoxia|response to ischemia|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|transcription factor binding|negative regulation of cell population proliferation|regulation of gene expression|negative regulation of gene expression|transcription repressor complex|negative regulation of aldosterone biosynthetic process|somatic stem cell population maintenance|cellular response to drug|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation by host of viral transcription|negative regulation of neuron differentiation|positive regulation of neuron differentiation|regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of calcium ion-dependent exocytosis|negative regulation of insulin secretion|metal ion binding|negative regulation of neurogenesis|cardiac muscle cell myoblast differentiation|histone H4 deacetylation|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|neuronal stem cell population maintenance|modification of synaptic structure|positive regulation of stem cell population maintenance|regulation of oxidative stress-induced neuron death|negative regulation of oxidative stress-induced neuron death|positive regulation of oxidative stress-induced neuron death|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of mesenchymal stem cell differentiation|negative regulation of amniotic stem cell differentiation" "hsa04550,hsa05016" Signaling pathways regulating pluripotency of stem cells|Huntington disease zf-C2H2 RET 6.366400604 3.121241648 9.61155956 3.079402572 1.622650484 0.289347527 1 0.024754782 0.074954336 5979 ret proto-oncogene "GO:0000165,GO:0000187,GO:0001657,GO:0001755,GO:0001838,GO:0004713,GO:0004714,GO:0005509,GO:0005515,GO:0005524,GO:0005769,GO:0005886,GO:0005887,GO:0006468,GO:0007156,GO:0007158,GO:0007165,GO:0007169,GO:0007275,GO:0007411,GO:0007497,GO:0010008,GO:0010976,GO:0014042,GO:0018108,GO:0030155,GO:0030335,GO:0030424,GO:0030425,GO:0033141,GO:0033619,GO:0033630,GO:0033674,GO:0035799,GO:0035860,GO:0038023,GO:0042493,GO:0042551,GO:0043025,GO:0043235,GO:0043410,GO:0045121,GO:0045793,GO:0045893,GO:0048265,GO:0048484,GO:0050770,GO:0051897,GO:0060041,GO:0060384,GO:0061146,GO:0071300,GO:0072300,GO:0097021,GO:0098797,GO:2001241" "MAPK cascade|activation of MAPK activity|ureteric bud development|neural crest cell migration|embryonic epithelial tube formation|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|calcium ion binding|protein binding|ATP binding|early endosome|plasma membrane|integral component of plasma membrane|protein phosphorylation|homophilic cell adhesion via plasma membrane adhesion molecules|neuron cell-cell adhesion|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|posterior midgut development|endosome membrane|positive regulation of neuron projection development|positive regulation of neuron maturation|peptidyl-tyrosine phosphorylation|regulation of cell adhesion|positive regulation of cell migration|axon|dendrite|positive regulation of peptidyl-serine phosphorylation of STAT protein|membrane protein proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of kinase activity|ureter maturation|glial cell-derived neurotrophic factor receptor signaling pathway|signaling receptor activity|response to drug|neuron maturation|neuronal cell body|receptor complex|positive regulation of MAPK cascade|membrane raft|positive regulation of cell size|positive regulation of transcription, DNA-templated|response to pain|enteric nervous system development|regulation of axonogenesis|positive regulation of protein kinase B signaling|retina development in camera-type eye|innervation|Peyer's patch morphogenesis|cellular response to retinoic acid|positive regulation of metanephric glomerulus development|lymphocyte migration into lymphoid organs|plasma membrane protein complex|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa04020,hsa05200,hsa05216,hsa05223,hsa05230" Calcium signaling pathway|Pathways in cancer|Thyroid cancer|Non-small cell lung cancer|Central carbon metabolism in cancer RETREG1 136.5923574 129.0113214 144.1733934 1.117525127 0.16030727 0.715352126 1 1.623460767 1.783899046 54463 reticulophagy regulator 1 "GO:0005515,GO:0005730,GO:0005783,GO:0005801,GO:0016604,GO:0019233,GO:0030176,GO:0043524,GO:0061709" protein binding|nucleolus|endoplasmic reticulum|cis-Golgi network|nuclear body|sensory perception of pain|integral component of endoplasmic reticulum membrane|negative regulation of neuron apoptotic process|reticulophagy RETREG2 2285.382604 2201.515776 2369.249432 1.076190077 0.105932909 0.655059874 1 24.93439107 26.38511118 79137 reticulophagy regulator family member 2 "GO:0005515,GO:0016021" protein binding|integral component of membrane RETREG3 743.2611329 777.1891703 709.3330955 0.912690401 -0.131802537 0.606701326 1 10.79010344 9.68323049 162427 reticulophagy regulator family member 3 "GO:0005515,GO:0010976,GO:0016021,GO:0032991,GO:0061709" protein binding|positive regulation of neuron projection development|integral component of membrane|protein-containing complex|reticulophagy RETSAT 1901.258603 1958.058927 1844.45828 0.941983029 -0.086227026 0.717245512 1 33.26902457 30.81444322 54884 retinol saturase "GO:0005640,GO:0005789,GO:0016020,GO:0016491,GO:0031965,GO:0042572,GO:0051786,GO:0055114" "nuclear outer membrane|endoplasmic reticulum membrane|membrane|oxidoreductase activity|nuclear membrane|retinol metabolic process|all-trans-retinol 13,14-reductase activity|oxidation-reduction process" hsa00830 Retinol metabolism REV1 926.414834 942.6149777 910.2146903 0.965627231 -0.050461734 0.842498194 1 8.729069739 8.287979078 51455 REV1 DNA directed polymerase "GO:0003684,GO:0003887,GO:0005515,GO:0005654,GO:0006260,GO:0009411,GO:0017125,GO:0019985,GO:0042276,GO:0046872,GO:0070987" damaged DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleoplasm|DNA replication|response to UV|deoxycytidyl transferase activity|translesion synthesis|error-prone translesion synthesis|metal ion binding|error-free translesion synthesis hsa03460 Fanconi anemia pathway REV3L 604.314961 725.1684762 483.4614459 0.666688448 -0.584915366 0.025908847 0.86539048 3.361788462 2.203760988 5980 "REV3 like, DNA directed polymerase zeta catalytic subunit" "GO:0000166,GO:0000724,GO:0003677,GO:0003887,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006261,GO:0008408,GO:0016035,GO:0042276,GO:0046872,GO:0051539,GO:0090305" "nucleotide binding|double-strand break repair via homologous recombination|DNA binding|DNA-directed DNA polymerase activity|protein binding|nucleus|nucleoplasm|nucleolus|DNA-dependent DNA replication|3'-5' exonuclease activity|zeta DNA polymerase complex|error-prone translesion synthesis|metal ion binding|4 iron, 4 sulfur cluster binding|nucleic acid phosphodiester bond hydrolysis" "hsa01524,hsa03460" Platinum drug resistance|Fanconi anemia pathway REX1BD 153.4025258 153.9812546 152.823797 0.992483126 -0.01088552 0.996987441 1 10.71407634 10.45560209 55049 required for excision 1-B domain containing GO:0005515 protein binding REXO1 497.1774832 448.4183834 545.936583 1.217471458 0.283887951 0.300589332 1 4.317384984 5.168336046 57455 RNA exonuclease 1 homolog "GO:0003676,GO:0004527,GO:0005634,GO:0005654,GO:0016604,GO:0090305" nucleic acid binding|exonuclease activity|nucleus|nucleoplasm|nuclear body|nucleic acid phosphodiester bond hydrolysis hsa03008 Ribosome biogenesis in eukaryotes REXO2 1480.81631 1303.638595 1657.994024 1.271820296 0.346894837 0.146372772 1 64.41925539 80.55873363 25996 RNA exonuclease 2 "GO:0000175,GO:0003676,GO:0005634,GO:0005730,GO:0005739,GO:0005758,GO:0005759,GO:0005925,GO:0006139,GO:0008408,GO:0009117,GO:0090503" "3'-5'-exoribonuclease activity|nucleic acid binding|nucleus|nucleolus|mitochondrion|mitochondrial intermembrane space|mitochondrial matrix|focal adhesion|nucleobase-containing compound metabolic process|3'-5' exonuclease activity|nucleotide metabolic process|RNA phosphodiester bond hydrolysis, exonucleolytic" hsa03008 Ribosome biogenesis in eukaryotes REXO4 793.6469787 863.5435226 723.7504349 0.838116917 -0.254776581 0.312290695 1 17.56985539 14.47918017 57109 "REX4 homolog, 3'-5' exonuclease" "GO:0000726,GO:0000737,GO:0000738,GO:0003690,GO:0003697,GO:0003723,GO:0004519,GO:0004527,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006355,GO:0006364,GO:0008408,GO:0016607" "non-recombinational repair|DNA catabolic process, endonucleolytic|DNA catabolic process, exonucleolytic|double-stranded DNA binding|single-stranded DNA binding|RNA binding|endonuclease activity|exonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription, DNA-templated|rRNA processing|3'-5' exonuclease activity|nuclear speck" REXO5 374.828858 352.7003062 396.9574098 1.125480763 0.170541398 0.56710305 1 6.590674757 7.293552866 81691 RNA exonuclease 5 "GO:0003723,GO:0004527,GO:0005634,GO:0005730,GO:0070062,GO:0090305" RNA binding|exonuclease activity|nucleus|nucleolus|extracellular exosome|nucleic acid phosphodiester bond hydrolysis hsa03008 Ribosome biogenesis in eukaryotes RFC1 2659.392501 2797.67293 2521.112073 0.901146108 -0.150167058 0.525859703 1 30.63957775 27.14870796 5981 replication factor C subunit 1 "GO:0000122,GO:0003677,GO:0003689,GO:0003690,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005663,GO:0005730,GO:0005737,GO:0006261,GO:0006283,GO:0006296,GO:0006297,GO:0007004,GO:0008047,GO:0019904,GO:0019985,GO:0031391,GO:0032201,GO:0033683,GO:0042276,GO:0042769,GO:0043565,GO:0045893,GO:0050790,GO:0061860,GO:0070062,GO:0070987,GO:0090618" "negative regulation of transcription by RNA polymerase II|DNA binding|DNA clamp loader activity|double-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|DNA replication factor C complex|nucleolus|cytoplasm|DNA-dependent DNA replication|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|telomere maintenance via telomerase|enzyme activator activity|protein domain specific binding|translesion synthesis|Elg1 RFC-like complex|telomere maintenance via semi-conservative replication|nucleotide-excision repair, DNA incision|error-prone translesion synthesis|DNA damage response, detection of DNA damage|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|regulation of catalytic activity|DNA clamp unloader activity|extracellular exosome|error-free translesion synthesis|DNA clamp unloading" "hsa03030,hsa03420,hsa03430" DNA replication|Nucleotide excision repair|Mismatch repair RFC2 1460.805027 1371.265497 1550.344557 1.13059401 0.177080958 0.459481564 1 43.0735252 47.88376328 5982 replication factor C subunit 2 "GO:0003689,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005663,GO:0006260,GO:0006261,GO:0006281,GO:0006283,GO:0006296,GO:0006297,GO:0017116,GO:0019899,GO:0019985,GO:0031390,GO:0032201,GO:0032508,GO:0033683,GO:0042276,GO:0042769,GO:0070987,GO:1900264,GO:1901796" "DNA clamp loader activity|protein binding|ATP binding|nucleus|nucleoplasm|DNA replication factor C complex|DNA replication|DNA-dependent DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|single-stranded DNA helicase activity|enzyme binding|translesion synthesis|Ctf18 RFC-like complex|telomere maintenance via semi-conservative replication|DNA duplex unwinding|nucleotide-excision repair, DNA incision|error-prone translesion synthesis|DNA damage response, detection of DNA damage|error-free translesion synthesis|positive regulation of DNA-directed DNA polymerase activity|regulation of signal transduction by p53 class mediator" "hsa03030,hsa03420,hsa03430" DNA replication|Nucleotide excision repair|Mismatch repair RFC3 1605.016821 1574.146204 1635.887437 1.039222045 0.05550394 0.817813231 1 7.470812785 7.633916101 5983 replication factor C subunit 3 "GO:0000731,GO:0003677,GO:0003689,GO:0005515,GO:0005634,GO:0005654,GO:0005663,GO:0006260,GO:0006261,GO:0006271,GO:0006281,GO:0006283,GO:0006296,GO:0006297,GO:0016887,GO:0017116,GO:0019985,GO:0031390,GO:0032201,GO:0032508,GO:0033683,GO:0042276,GO:0042769,GO:0046683,GO:0070987,GO:1900264,GO:1901796" "DNA synthesis involved in DNA repair|DNA binding|DNA clamp loader activity|protein binding|nucleus|nucleoplasm|DNA replication factor C complex|DNA replication|DNA-dependent DNA replication|DNA strand elongation involved in DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|ATPase activity|single-stranded DNA helicase activity|translesion synthesis|Ctf18 RFC-like complex|telomere maintenance via semi-conservative replication|DNA duplex unwinding|nucleotide-excision repair, DNA incision|error-prone translesion synthesis|DNA damage response, detection of DNA damage|response to organophosphorus|error-free translesion synthesis|positive regulation of DNA-directed DNA polymerase activity|regulation of signal transduction by p53 class mediator" "hsa03030,hsa03420,hsa03430" DNA replication|Nucleotide excision repair|Mismatch repair RFC4 858.7728404 844.8160727 872.729608 1.033040962 0.04689746 0.855350926 1 33.03024256 33.55061487 5984 replication factor C subunit 4 "GO:0003689,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005663,GO:0006260,GO:0006261,GO:0006271,GO:0006281,GO:0006283,GO:0006296,GO:0006297,GO:0017116,GO:0019985,GO:0031390,GO:0031391,GO:0032201,GO:0032508,GO:0033683,GO:0042276,GO:0042769,GO:0070987,GO:1900264,GO:1901796" "DNA clamp loader activity|protein binding|ATP binding|nucleus|nucleoplasm|DNA replication factor C complex|DNA replication|DNA-dependent DNA replication|DNA strand elongation involved in DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|single-stranded DNA helicase activity|translesion synthesis|Ctf18 RFC-like complex|Elg1 RFC-like complex|telomere maintenance via semi-conservative replication|DNA duplex unwinding|nucleotide-excision repair, DNA incision|error-prone translesion synthesis|DNA damage response, detection of DNA damage|error-free translesion synthesis|positive regulation of DNA-directed DNA polymerase activity|regulation of signal transduction by p53 class mediator" "hsa03030,hsa03420,hsa03430" DNA replication|Nucleotide excision repair|Mismatch repair RFC5 1275.83281 1246.415831 1305.249788 1.047202511 0.066540462 0.785116521 1 32.11922844 33.07249487 5985 replication factor C subunit 5 "GO:0003689,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005663,GO:0006260,GO:0006261,GO:0006281,GO:0006283,GO:0006296,GO:0006297,GO:0017116,GO:0019899,GO:0019985,GO:0031390,GO:0032201,GO:0032508,GO:0033683,GO:0042276,GO:0042769,GO:0070987,GO:1900264,GO:1901796" "DNA clamp loader activity|protein binding|ATP binding|nucleus|nucleoplasm|DNA replication factor C complex|DNA replication|DNA-dependent DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|single-stranded DNA helicase activity|enzyme binding|translesion synthesis|Ctf18 RFC-like complex|telomere maintenance via semi-conservative replication|DNA duplex unwinding|nucleotide-excision repair, DNA incision|error-prone translesion synthesis|DNA damage response, detection of DNA damage|error-free translesion synthesis|positive regulation of DNA-directed DNA polymerase activity|regulation of signal transduction by p53 class mediator" "hsa03030,hsa03420,hsa03430" DNA replication|Nucleotide excision repair|Mismatch repair RFESD 62.52924298 64.50566072 60.55282523 0.938721107 -0.091231497 0.897867711 1 0.887026168 0.818736578 317671 Rieske Fe-S domain containing "GO:0005515,GO:0046872,GO:0051537,GO:0055114" "protein binding|metal ion binding|2 iron, 2 sulfur cluster binding|oxidation-reduction process" RFFL 950.0713666 1071.626299 828.5164341 0.773139325 -0.371199673 0.132773332 1 7.932139531 6.030027431 117584 ring finger and FYVE like domain containing E3 ubiquitin protein ligase "GO:0000139,GO:0002020,GO:0002039,GO:0005515,GO:0005654,GO:0005737,GO:0005764,GO:0005829,GO:0005886,GO:0006511,GO:0006915,GO:0010008,GO:0010762,GO:0010804,GO:0016020,GO:0019901,GO:0031625,GO:0032006,GO:0043161,GO:0046872,GO:0055038,GO:0061630,GO:0070936,GO:1901797,GO:1902042,GO:2001271" Golgi membrane|protease binding|p53 binding|protein binding|nucleoplasm|cytoplasm|lysosome|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|apoptotic process|endosome membrane|regulation of fibroblast migration|negative regulation of tumor necrosis factor-mediated signaling pathway|membrane|protein kinase binding|ubiquitin protein ligase binding|regulation of TOR signaling|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|recycling endosome membrane|ubiquitin protein ligase activity|protein K48-linked ubiquitination|negative regulation of signal transduction by p53 class mediator|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis RFK 498.5745578 459.8629361 537.2861794 1.168361564 0.224486804 0.413787597 1 9.453790335 10.8606147 55312 riboflavin kinase "GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005829,GO:0006771,GO:0006915,GO:0008531,GO:0009231,GO:0009398,GO:0016310,GO:0033864,GO:0046872,GO:0072593" protein binding|ATP binding|cytoplasm|mitochondrion|cytosol|riboflavin metabolic process|apoptotic process|riboflavin kinase activity|riboflavin biosynthetic process|FMN biosynthetic process|phosphorylation|positive regulation of NAD(P)H oxidase activity|metal ion binding|reactive oxygen species metabolic process hsa00740 Riboflavin metabolism RFLNB 655.1373398 722.0472346 588.2274451 0.814666156 -0.29571912 0.253648548 1 10.63896572 8.522171365 359845 refilin B "GO:0001837,GO:0005737,GO:0031005,GO:0032432,GO:0048705,GO:0061182,GO:0061572,GO:1900158" epithelial to mesenchymal transition|cytoplasm|filamin binding|actin filament bundle|skeletal system morphogenesis|negative regulation of chondrocyte development|actin filament bundle organization|negative regulation of bone mineralization involved in bone maturation RFNG 700.138677 654.4203322 745.8570219 1.139721652 0.188681525 0.46333687 1 18.54764225 20.78541442 5986 RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase "GO:0003674,GO:0005576,GO:0007389,GO:0007399,GO:0008375,GO:0008593,GO:0009887,GO:0030154,GO:0030173,GO:0032092,GO:0033829,GO:0045747,GO:0046872" molecular_function|extracellular region|pattern specification process|nervous system development|acetylglucosaminyltransferase activity|regulation of Notch signaling pathway|animal organ morphogenesis|cell differentiation|integral component of Golgi membrane|positive regulation of protein binding|O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity|positive regulation of Notch signaling pathway|metal ion binding "hsa00514,hsa04330,hsa05165" Other types of O-glycan biosynthesis|Notch signaling pathway|Human papillomavirus infection RFPL4AL1 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.04737626 0.129104366 729974 ret finger protein like 4A like 1 "GO:0000785,GO:0004842,GO:0005654,GO:0016567,GO:0045893,GO:0046872" "chromatin|ubiquitin-protein transferase activity|nucleoplasm|protein ubiquitination|positive regulation of transcription, DNA-templated|metal ion binding" RFT1 757.847049 756.3808927 759.3132052 1.003876767 0.005582179 0.988360156 1 3.504658628 3.459372301 91869 RFT1 homolog "GO:0005515,GO:0005789,GO:0006488,GO:0008643,GO:0016021,GO:0034203" protein binding|endoplasmic reticulum membrane|dolichol-linked oligosaccharide biosynthetic process|carbohydrate transport|integral component of membrane|glycolipid translocation RFTN1 1223.019536 1121.566165 1324.472907 1.180913751 0.2399036 0.321485742 1 13.339854 15.48960827 23180 "raftlin, lipid raft linker 1" "GO:0001765,GO:0002457,GO:0003725,GO:0005737,GO:0005768,GO:0005769,GO:0005886,GO:0032596,GO:0032620,GO:0032991,GO:0033227,GO:0034138,GO:0040010,GO:0043330,GO:0045121,GO:0050852,GO:0050853,GO:0070062,GO:1903044" membrane raft assembly|T cell antigen processing and presentation|double-stranded RNA binding|cytoplasm|endosome|early endosome|plasma membrane|protein transport into membrane raft|interleukin-17 production|protein-containing complex|dsRNA transport|toll-like receptor 3 signaling pathway|positive regulation of growth rate|response to exogenous dsRNA|membrane raft|T cell receptor signaling pathway|B cell receptor signaling pathway|extracellular exosome|protein localization to membrane raft RFWD3 2954.778153 3020.321501 2889.234804 0.956598429 -0.064014673 0.787884911 1 25.19759378 23.70063119 55159 ring finger and WD repeat domain 3 "GO:0000724,GO:0002039,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006974,GO:0010212,GO:0016567,GO:0016605,GO:0031052,GO:0031297,GO:0031571,GO:0035861,GO:0036297,GO:0046872,GO:0061630,GO:0090734,GO:0097371,GO:2000001" double-strand break repair via homologous recombination|p53 binding|protein binding|nucleus|nucleoplasm|cytoplasm|cellular response to DNA damage stimulus|response to ionizing radiation|protein ubiquitination|PML body|chromosome breakage|replication fork processing|mitotic G1 DNA damage checkpoint|site of double-strand break|interstrand cross-link repair|metal ion binding|ubiquitin protein ligase activity|site of DNA damage|MDM2/MDM4 family protein binding|regulation of DNA damage checkpoint RFX1 262.8843717 277.7905067 247.9782366 0.892680746 -0.163783786 0.62573763 1 2.649717388 2.325770736 5989 regulatory factor X1 "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005654,GO:0006357,GO:0006955,GO:0043231,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|immune response|intracellular membrane-bounded organelle|sequence-specific double-stranded DNA binding" RFX2 139.9067135 152.9408407 126.8725862 0.829553346 -0.269593335 0.524246955 1 2.05959414 1.679953054 5990 regulatory factor X2 "GO:0000785,GO:0000978,GO:0000981,GO:0001675,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0007286,GO:0060271,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|acrosome assembly|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|spermatid development|cilium assembly|sequence-specific double-stranded DNA binding" RFX RFX3 245.3508211 259.0630568 231.6385854 0.894139783 -0.161427706 0.639433723 1 0.815243776 0.716744038 5991 regulatory factor X3 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0003677,GO:0003700,GO:0005515,GO:0005576,GO:0005634,GO:0005667,GO:0006351,GO:0006355,GO:0006357,GO:0031018,GO:0045892,GO:0045893,GO:0045944,GO:0048469,GO:0050796,GO:0060271,GO:0060285,GO:0060287,GO:0072560,GO:1990837,GO:2000078" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|extracellular region|nucleus|transcription regulator complex|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|endocrine pancreas development|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cell maturation|regulation of insulin secretion|cilium assembly|cilium-dependent cell motility|epithelial cilium movement involved in determination of left/right asymmetry|type B pancreatic cell maturation|sequence-specific double-stranded DNA binding|positive regulation of type B pancreatic cell development" RFX RFX5 1209.602368 1223.526726 1195.678009 0.97723898 -0.033216685 0.894196556 1 16.9208014 16.25896471 5993 regulatory factor X5 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0006357,GO:0043565,GO:0045944,GO:0090575,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulator complex|sequence-specific double-stranded DNA binding" "hsa04612,hsa05152,hsa05340" Antigen processing and presentation|Tuberculosis|Primary immunodeficiency RFX RFX6 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.044396303 0.026885273 222546 regulatory factor X6 "GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0003309,GO:0003310,GO:0003311,GO:0005515,GO:0005634,GO:0006357,GO:0031018,GO:0035774,GO:0042593,GO:0045893,GO:0045944,GO:0050796,GO:0090104" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|type B pancreatic cell differentiation|pancreatic A cell differentiation|pancreatic D cell differentiation|protein binding|nucleus|regulation of transcription by RNA polymerase II|endocrine pancreas development|positive regulation of insulin secretion involved in cellular response to glucose stimulus|glucose homeostasis|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of insulin secretion|pancreatic epsilon cell differentiation" hsa04950 Maturity onset diabetes of the young RFX7 331.1409214 341.2557535 321.0260893 0.940719932 -0.088162822 0.780984651 1 1.183147688 1.094385888 64864 regulatory factor X7 "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" RFX8 27.78923438 10.40413883 45.17432993 4.341957627 2.118345647 0.006954643 0.503199667 0.155227779 0.66271409 731220 regulatory factor X8 "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0006357" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II" RFXANK 557.3629726 564.9447383 549.7812068 0.973159266 -0.039252161 0.889753672 1 19.02212136 18.20178788 8625 regulatory factor X associated ankyrin containing protein "GO:0000977,GO:0001228,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007265,GO:0010468,GO:0042826,GO:0045171,GO:0045944,GO:0090575" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|Ras protein signal transduction|regulation of gene expression|histone deacetylase binding|intercellular bridge|positive regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulator complex" "hsa04612,hsa05152,hsa05340" Antigen processing and presentation|Tuberculosis|Primary immunodeficiency RFXAP 202.7284504 187.2744989 218.182402 1.16504064 0.220380281 0.548789159 1 4.334126543 4.964938129 5994 regulatory factor X associated protein "GO:0000977,GO:0001228,GO:0005634,GO:0006357,GO:0016607,GO:0045944,GO:0090575" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|nuclear speck|positive regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulator complex" "hsa04612,hsa05152,hsa05340" Antigen processing and presentation|Tuberculosis|Primary immunodeficiency RGCC 50.48019498 50.98028025 49.98010971 0.980381227 -0.028585236 0.999924193 1 2.840004028 2.737695368 28984 regulator of cell cycle "GO:0001100,GO:0001818,GO:0001819,GO:0001937,GO:0003331,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0006956,GO:0006977,GO:0008285,GO:0010628,GO:0010718,GO:0016525,GO:0019901,GO:0030295,GO:0032147,GO:0032967,GO:0043537,GO:0045737,GO:0045840,GO:0045944,GO:0051091,GO:0051496,GO:0070412,GO:0071158,GO:0071456,GO:0071850,GO:0072537,GO:0090272,GO:1900087,GO:1901203,GO:1901991,GO:2000048,GO:2000353,GO:2000573" "negative regulation of exit from mitosis|negative regulation of cytokine production|positive regulation of cytokine production|negative regulation of endothelial cell proliferation|positive regulation of extracellular matrix constituent secretion|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|cytosol|complement activation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell population proliferation|positive regulation of gene expression|positive regulation of epithelial to mesenchymal transition|negative regulation of angiogenesis|protein kinase binding|protein kinase activator activity|activation of protein kinase activity|positive regulation of collagen biosynthetic process|negative regulation of blood vessel endothelial cell migration|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of mitotic nuclear division|positive regulation of transcription by RNA polymerase II|positive regulation of DNA-binding transcription factor activity|positive regulation of stress fiber assembly|R-SMAD binding|positive regulation of cell cycle arrest|cellular response to hypoxia|mitotic cell cycle arrest|fibroblast activation|negative regulation of fibroblast growth factor production|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of extracellular matrix assembly|negative regulation of mitotic cell cycle phase transition|negative regulation of cell-cell adhesion mediated by cadherin|positive regulation of endothelial cell apoptotic process|positive regulation of DNA biosynthetic process" RGL1 304.6103674 288.1946455 321.0260893 1.113921075 0.155647017 0.625460262 1 2.933514887 3.213023454 23179 ral guanine nucleotide dissociation stimulator like 1 "GO:0005085,GO:0005515,GO:0005575,GO:0005829,GO:0007264,GO:0019216,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|cellular_component|cytosol|small GTPase mediated signal transduction|regulation of lipid metabolic process|regulation of catalytic activity hsa04014 Ras signaling pathway RGL2 1195.428447 1116.364096 1274.492798 1.141646173 0.191115589 0.430957409 1 20.50888125 23.02208611 5863 ral guanine nucleotide dissociation stimulator like 2 "GO:0005085,GO:0005515,GO:0005575,GO:0007265,GO:0010667,GO:0014068,GO:0032485,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|cellular_component|Ras protein signal transduction|negative regulation of cardiac muscle cell apoptotic process|positive regulation of phosphatidylinositol 3-kinase signaling|regulation of Ral protein signal transduction|regulation of catalytic activity hsa04014 Ras signaling pathway RGL3 421.7418319 410.9634836 432.5201802 1.052454044 0.073757238 0.803152088 1 8.672347095 8.974514655 57139 ral guanine nucleotide dissociation stimulator like 3 "GO:0005085,GO:0005515,GO:0007264,GO:0031267,GO:0043547" guanyl-nucleotide exchange factor activity|protein binding|small GTPase mediated signal transduction|small GTPase binding|positive regulation of GTPase activity RGMB 2756.110019 2397.113586 3115.106453 1.299523924 0.377983194 0.110166472 1 20.98581797 26.81521969 285704 repulsive guidance molecule BMP co-receptor b "GO:0005515,GO:0005793,GO:0005886,GO:0007155,GO:0007165,GO:0015026,GO:0030509,GO:0042802,GO:0045121,GO:0045893,GO:0046658" "protein binding|endoplasmic reticulum-Golgi intermediate compartment|plasma membrane|cell adhesion|signal transduction|coreceptor activity|BMP signaling pathway|identical protein binding|membrane raft|positive regulation of transcription, DNA-templated|anchored component of plasma membrane" hsa04350 TGF-beta signaling pathway RGP1 2113.891722 2014.241277 2213.542167 1.098945887 0.136120349 0.565691438 1 15.29544037 16.52758776 9827 "RGP1 homolog, RAB6A GEF complex partner 1" "GO:0000139,GO:0005085,GO:0005515,GO:0005829,GO:0005886,GO:0016020,GO:0031267,GO:0032588,GO:0032991,GO:0034066,GO:0042147,GO:0043547,GO:1903363" "Golgi membrane|guanyl-nucleotide exchange factor activity|protein binding|cytosol|plasma membrane|membrane|small GTPase binding|trans-Golgi network membrane|protein-containing complex|RIC1-RGP1 guanyl-nucleotide exchange factor complex|retrograde transport, endosome to Golgi|positive regulation of GTPase activity|negative regulation of cellular protein catabolic process" RGPD3 14.45193789 13.52538047 15.3784953 1.137010181 0.185245172 0.923276611 1 0.083322717 0.093153452 653489 RANBP2 like and GRIP domain containing 3 "GO:0005096,GO:0005643,GO:0005737,GO:0006607,GO:0043547" GTPase activator activity|nuclear pore|cytoplasm|NLS-bearing protein import into nucleus|positive regulation of GTPase activity RGPD4 46.95763328 46.81862472 47.09664184 1.005938174 0.008541638 1 1 0.304227926 0.300913411 285190 RANBP2 like and GRIP domain containing 4 "GO:0005096,GO:0005643,GO:0005737,GO:0006607,GO:0043547" GTPase activator activity|nuclear pore|cytoplasm|NLS-bearing protein import into nucleus|positive regulation of GTPase activity RGPD5 27.73954458 34.33365813 21.14543103 0.615880514 -0.699277611 0.358950972 1 0.178885505 0.108328516 84220 RANBP2 like and GRIP domain containing 5 "GO:0005096,GO:0005643,GO:0005737,GO:0006607,GO:0043547" GTPase activator activity|nuclear pore|cytoplasm|NLS-bearing protein import into nucleus|positive regulation of GTPase activity RGPD6 13.72855571 19.76786377 7.689247648 0.388977167 -1.362242623 0.177690477 1 0.090501378 0.034613895 729540 RANBP2 like and GRIP domain containing 6 "GO:0005096,GO:0005643,GO:0005737,GO:0006607,GO:0043547" GTPase activator activity|nuclear pore|cytoplasm|NLS-bearing protein import into nucleus|positive regulation of GTPase activity RGPD8 151.5248733 142.5367019 160.5130447 1.126117291 0.1713571 0.682750811 1 0.536340817 0.593875836 727851 RANBP2 like and GRIP domain containing 8 "GO:0005096,GO:0005643,GO:0005737,GO:0006607,GO:0008150,GO:0031267,GO:0043547" GTPase activator activity|nuclear pore|cytoplasm|NLS-bearing protein import into nucleus|biological_process|small GTPase binding|positive regulation of GTPase activity RGS10 852.1139458 871.8668337 832.3610579 0.954688292 -0.066898329 0.792768537 1 44.48368116 41.75740427 6001 regulator of G protein signaling 10 "GO:0001965,GO:0001975,GO:0003924,GO:0005096,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0007186,GO:0007213,GO:0008277,GO:0009968,GO:0043025,GO:0043197,GO:0043547,GO:0043679" G-protein alpha-subunit binding|response to amphetamine|GTPase activity|GTPase activator activity|protein binding|nucleus|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|G protein-coupled acetylcholine receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|negative regulation of signal transduction|neuronal cell body|dendritic spine|positive regulation of GTPase activity|axon terminus RGS12 358.0482578 353.7407201 362.3557954 1.024354209 0.034714667 0.917145686 1 1.489779994 1.500525819 6002 regulator of G protein signaling 12 "GO:0000794,GO:0003924,GO:0005096,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0007186,GO:0008277,GO:0009968,GO:0016363,GO:0030425,GO:0030695,GO:0043547,GO:0045202" condensed nuclear chromosome|GTPase activity|GTPase activator activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|negative regulation of signal transduction|nuclear matrix|dendrite|GTPase regulator activity|positive regulation of GTPase activity|synapse RGS14 309.8124368 298.5987843 321.0260893 1.075108494 0.104482256 0.745494479 1 6.181407416 6.534477102 10636 regulator of G protein signaling 14 "GO:0000278,GO:0000922,GO:0001965,GO:0003924,GO:0005092,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005819,GO:0005874,GO:0005886,GO:0006913,GO:0006979,GO:0007051,GO:0007059,GO:0007186,GO:0007612,GO:0007616,GO:0008017,GO:0008277,GO:0008542,GO:0010070,GO:0014069,GO:0016604,GO:0016605,GO:0019901,GO:0030159,GO:0030425,GO:0031914,GO:0032794,GO:0035556,GO:0043197,GO:0043407,GO:0043547,GO:0043620,GO:0045744,GO:0048008,GO:0050769,GO:0051301,GO:0060291,GO:0070373,GO:0098978" mitotic cell cycle|spindle pole|G-protein alpha-subunit binding|GTPase activity|GDP-dissociation inhibitor activity|GTPase activator activity|protein binding|nucleus|cytoplasm|centrosome|spindle|microtubule|plasma membrane|nucleocytoplasmic transport|response to oxidative stress|spindle organization|chromosome segregation|G protein-coupled receptor signaling pathway|learning|long-term memory|microtubule binding|regulation of G protein-coupled receptor signaling pathway|visual learning|zygote asymmetric cell division|postsynaptic density|nuclear body|PML body|protein kinase binding|signaling receptor complex adaptor activity|dendrite|negative regulation of synaptic plasticity|GTPase activating protein binding|intracellular signal transduction|dendritic spine|negative regulation of MAP kinase activity|positive regulation of GTPase activity|regulation of DNA-templated transcription in response to stress|negative regulation of G protein-coupled receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|cell division|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|glutamatergic synapse hsa04015 Rap1 signaling pathway RGS17 370.488565 390.155206 350.8219239 0.899185551 -0.153309242 0.608904029 1 2.465293188 2.179661605 26575 regulator of G protein signaling 17 "GO:0001975,GO:0003924,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0007186,GO:0009968,GO:0043005,GO:0043547,GO:0045202" response to amphetamine|GTPase activity|GTPase activator activity|protein binding|nucleus|cytoplasm|plasma membrane|G protein-coupled receptor signaling pathway|negative regulation of signal transduction|neuron projection|positive regulation of GTPase activity|synapse RGS19 319.4491485 236.1739514 402.7243456 1.705202217 0.769942836 0.012790339 0.667587345 5.492012948 9.208282187 10287 regulator of G protein signaling 19 "GO:0001965,GO:0003924,GO:0005515,GO:0005794,GO:0005886,GO:0005903,GO:0006914,GO:0007186,GO:0007264,GO:0009968,GO:0016020,GO:0030136,GO:0045121,GO:0045471" G-protein alpha-subunit binding|GTPase activity|protein binding|Golgi apparatus|plasma membrane|brush border|autophagy|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|negative regulation of signal transduction|membrane|clathrin-coated vesicle|membrane raft|response to ethanol RGS2 112.969809 114.4455271 111.4940909 0.974210996 -0.037693828 0.95446799 1 4.53096991 4.340256375 5997 regulator of G protein signaling 2 "GO:0001965,GO:0001975,GO:0003924,GO:0005096,GO:0005515,GO:0005516,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0007049,GO:0007186,GO:0007283,GO:0007420,GO:0008277,GO:0009898,GO:0010519,GO:0010614,GO:0010976,GO:0017148,GO:0030728,GO:0043005,GO:0043407,GO:0043547,GO:0043951,GO:0045471,GO:0045744,GO:0048487,GO:0050873,GO:0055119,GO:0060087,GO:0060135,GO:0060452,GO:0061052,GO:0140194,GO:1900924" G-protein alpha-subunit binding|response to amphetamine|GTPase activity|GTPase activator activity|protein binding|calmodulin binding|nucleus|nucleolus|cytoplasm|mitochondrion|cytosol|plasma membrane|cell cycle|G protein-coupled receptor signaling pathway|spermatogenesis|brain development|regulation of G protein-coupled receptor signaling pathway|cytoplasmic side of plasma membrane|negative regulation of phospholipase activity|negative regulation of cardiac muscle hypertrophy|positive regulation of neuron projection development|negative regulation of translation|ovulation|neuron projection|negative regulation of MAP kinase activity|positive regulation of GTPase activity|negative regulation of cAMP-mediated signaling|response to ethanol|negative regulation of G protein-coupled receptor signaling pathway|beta-tubulin binding|brown fat cell differentiation|relaxation of cardiac muscle|relaxation of vascular associated smooth muscle|maternal process involved in female pregnancy|positive regulation of cardiac muscle contraction|negative regulation of cell growth involved in cardiac muscle cell development|negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process|negative regulation of glycine import across plasma membrane "hsa04022,hsa04740,hsa04921" cGMP-PKG signaling pathway|Olfactory transduction|Oxytocin signaling pathway RGS20 530.7185621 496.277422 565.1597021 1.138797932 0.187511779 0.489511084 1 11.36225392 12.72278942 8601 regulator of G protein signaling 20 "GO:0003924,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005802,GO:0005886,GO:0007186,GO:0008277,GO:0009968,GO:0043547" GTPase activity|GTPase activator activity|protein binding|nucleus|cytoplasm|trans-Golgi network|plasma membrane|G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|negative regulation of signal transduction|positive regulation of GTPase activity RGS3 807.7529312 741.8150983 873.690764 1.177774308 0.236063108 0.348489663 1 5.561077174 6.440093563 5998 regulator of G protein signaling 3 "GO:0000188,GO:0003924,GO:0005096,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0007165,GO:0007186,GO:0008277,GO:0043547" inactivation of MAPK activity|GTPase activity|GTPase activator activity|protein binding|nucleus|cytosol|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|positive regulation of GTPase activity hsa04360 Axon guidance RGS4 140.8137636 88.43518002 193.1923472 2.184564413 1.127345645 0.007055006 0.504530246 1.366422415 2.935087216 5999 regulator of G protein signaling 4 "GO:0000188,GO:0001965,GO:0001975,GO:0003924,GO:0005096,GO:0005516,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007186,GO:0007420,GO:0008277,GO:0010460,GO:0032991,GO:0042220,GO:0043278,GO:0043547,GO:0045471,GO:0045744,GO:0051924,GO:0060160,GO:0061052,GO:0110053,GO:1900924,GO:1901380,GO:1990791,GO:2000463" inactivation of MAPK activity|G-protein alpha-subunit binding|response to amphetamine|GTPase activity|GTPase activator activity|calmodulin binding|nucleus|cytoplasm|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|brain development|regulation of G protein-coupled receptor signaling pathway|positive regulation of heart rate|protein-containing complex|response to cocaine|response to morphine|positive regulation of GTPase activity|response to ethanol|negative regulation of G protein-coupled receptor signaling pathway|regulation of calcium ion transport|negative regulation of dopamine receptor signaling pathway|negative regulation of cell growth involved in cardiac muscle cell development|regulation of actin filament organization|negative regulation of glycine import across plasma membrane|negative regulation of potassium ion transmembrane transport|dorsal root ganglion development|positive regulation of excitatory postsynaptic potential RGS5 50.51479353 64.50566072 36.52392633 0.566212731 -0.820583907 0.170089354 1 0.584175896 0.325232878 8490 regulator of G protein signaling 5 "GO:0003924,GO:0005096,GO:0005515,GO:0005737,GO:0005886,GO:0007186,GO:0008277,GO:0009968,GO:0043547" GTPase activity|GTPase activator activity|protein binding|cytoplasm|plasma membrane|G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|negative regulation of signal transduction|positive regulation of GTPase activity RGS7 9.408384325 7.282897178 11.53387147 1.583692752 0.663292469 0.627344635 1 0.057786922 0.089985321 6000 regulator of G protein signaling 7 "GO:0003924,GO:0005096,GO:0005829,GO:0005886,GO:0006457,GO:0007186,GO:0009968,GO:0031681,GO:0035556,GO:0043547" GTPase activity|GTPase activator activity|cytosol|plasma membrane|protein folding|G protein-coupled receptor signaling pathway|negative regulation of signal transduction|G-protein beta-subunit binding|intracellular signal transduction|positive regulation of GTPase activity RGS7BP 3.443303773 2.080827765 4.80577978 2.309551929 1.207612985 0.648665767 1 0.024083703 0.054691794 401190 regulator of G protein signaling 7 binding protein "GO:0005634,GO:0005737,GO:0007186,GO:0009968,GO:0060078,GO:0098978,GO:0099026,GO:0099031" nucleus|cytoplasm|G protein-coupled receptor signaling pathway|negative regulation of signal transduction|regulation of postsynaptic membrane potential|glutamatergic synapse|anchored component of presynaptic membrane|anchored component of postsynaptic density membrane RGS9 50.15813286 55.14193578 45.17432993 0.819237288 -0.287646713 0.651164013 1 0.572533807 0.461192276 8787 regulator of G protein signaling 9 "GO:0001975,GO:0003924,GO:0005096,GO:0005634,GO:0005737,GO:0005886,GO:0006457,GO:0007186,GO:0007212,GO:0007399,GO:0007601,GO:0008277,GO:0009968,GO:0032355,GO:0035556,GO:0043547,GO:0098839,GO:0098978,GO:1904783,GO:1905912" response to amphetamine|GTPase activity|GTPase activator activity|nucleus|cytoplasm|plasma membrane|protein folding|G protein-coupled receptor signaling pathway|dopamine receptor signaling pathway|nervous system development|visual perception|regulation of G protein-coupled receptor signaling pathway|negative regulation of signal transduction|response to estradiol|intracellular signal transduction|positive regulation of GTPase activity|postsynaptic density membrane|glutamatergic synapse|positive regulation of NMDA glutamate receptor activity|regulation of calcium ion export across plasma membrane "hsa04744,hsa05030" Phototransduction|Cocaine addiction RGS9BP 8.045908318 9.363724944 6.728091692 0.718527267 -0.476885189 0.786592357 1 0.203719849 0.143928825 388531 regulator of G protein signaling 9 binding protein "GO:0001750,GO:0009968,GO:0016021,GO:0050908" photoreceptor outer segment|negative regulation of signal transduction|integral component of membrane|detection of light stimulus involved in visual perception RHBDD1 698.0125755 762.623376 633.401775 0.830556465 -0.267849843 0.29654242 1 4.44175575 3.627396375 84236 rhomboid domain containing 1 "GO:0004252,GO:0005515,GO:0005783,GO:0005789,GO:0006915,GO:0010954,GO:0030176,GO:0031293,GO:0031966,GO:0034620,GO:0034644,GO:0036503,GO:0043066,GO:0043687,GO:0044322,GO:0048515,GO:1904211,GO:2000254" "serine-type endopeptidase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|apoptotic process|positive regulation of protein processing|integral component of endoplasmic reticulum membrane|membrane protein intracellular domain proteolysis|mitochondrial membrane|cellular response to unfolded protein|cellular response to UV|ERAD pathway|negative regulation of apoptotic process|post-translational protein modification|endoplasmic reticulum quality control compartment|spermatid differentiation|membrane protein proteolysis involved in retrograde protein transport, ER to cytosol|regulation of male germ cell proliferation" RHBDD2 920.8762256 872.9072475 968.8452036 1.109906243 0.150437813 0.545670382 1 16.24885088 17.73291473 57414 rhomboid domain containing 2 "GO:0000139,GO:0000839,GO:0004252,GO:0005654,GO:0005794,GO:0030176,GO:0030433,GO:0030968,GO:0048471,GO:0051787,GO:1990381" Golgi membrane|Hrd1p ubiquitin ligase ERAD-L complex|serine-type endopeptidase activity|nucleoplasm|Golgi apparatus|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|perinuclear region of cytoplasm|misfolded protein binding|ubiquitin-specific protease binding RHBDD3 225.8106703 250.7397457 200.8815948 0.801155773 -0.319845314 0.359479287 1 6.962288964 5.484539762 25807 rhomboid domain containing 3 "GO:0000165,GO:0001889,GO:0002673,GO:0004252,GO:0006508,GO:0009410,GO:0016021,GO:0032815,GO:0045732,GO:0050708" MAPK cascade|liver development|regulation of acute inflammatory response|serine-type endopeptidase activity|proteolysis|response to xenobiotic stimulus|integral component of membrane|negative regulation of natural killer cell activation|positive regulation of protein catabolic process|regulation of protein secretion RHBDF1 901.875789 916.6046306 887.1469474 0.967862171 -0.047126481 0.853621934 1 14.32850161 13.63595222 64285 rhomboid 5 homolog 1 "GO:0000139,GO:0004252,GO:0005515,GO:0005789,GO:0006508,GO:0008283,GO:0015031,GO:0016021,GO:0016477,GO:0019838,GO:0042058,GO:0050708,GO:0050709,GO:0061136" Golgi membrane|serine-type endopeptidase activity|protein binding|endoplasmic reticulum membrane|proteolysis|cell population proliferation|protein transport|integral component of membrane|cell migration|growth factor binding|regulation of epidermal growth factor receptor signaling pathway|regulation of protein secretion|negative regulation of protein secretion|regulation of proteasomal protein catabolic process RHBDF2 623.7217481 666.9052988 580.5381974 0.870495704 -0.200090917 0.445243557 1 6.089223281 5.211943628 79651 rhomboid 5 homolog 2 "GO:0004252,GO:0005515,GO:0005789,GO:0005886,GO:0006508,GO:0015031,GO:0016021,GO:0019838,GO:0042058,GO:0050708,GO:0050709" serine-type endopeptidase activity|protein binding|endoplasmic reticulum membrane|plasma membrane|proteolysis|protein transport|integral component of membrane|growth factor binding|regulation of epidermal growth factor receptor signaling pathway|regulation of protein secretion|negative regulation of protein secretion RHBDL1 23.89995117 21.84869154 25.95121081 1.187769564 0.248254969 0.799317396 1 0.642791902 0.750712709 9028 rhomboid like 1 "GO:0004252,GO:0005515,GO:0005887,GO:0006508,GO:0007165,GO:0016020" serine-type endopeptidase activity|protein binding|integral component of plasma membrane|proteolysis|signal transduction|membrane RHBDL2 81.18246535 87.39476614 74.97016457 0.857833574 -0.221230314 0.676386885 1 2.32275799 1.959197333 54933 rhomboid like 2 "GO:0004252,GO:0005886,GO:0006508,GO:0016021" serine-type endopeptidase activity|plasma membrane|proteolysis|integral component of membrane RHBDL3 8.967435311 8.323311061 9.61155956 1.154775965 0.207612985 0.965671908 1 0.06053418 0.068733677 162494 rhomboid like 3 "GO:0004252,GO:0005509,GO:0006508,GO:0016021" serine-type endopeptidase activity|calcium ion binding|proteolysis|integral component of membrane RHBG 1.922311912 0 3.844623824 Inf Inf 0.288176591 1 0 0.082649361 57127 Rh family B glycoprotein "GO:0005886,GO:0005887,GO:0008519,GO:0014731,GO:0015696,GO:0016323,GO:0030506,GO:0030659,GO:0046658,GO:0070634,GO:0072488" plasma membrane|integral component of plasma membrane|ammonium transmembrane transporter activity|spectrin-associated cytoskeleton|ammonium transport|basolateral plasma membrane|ankyrin binding|cytoplasmic vesicle membrane|anchored component of plasma membrane|transepithelial ammonium transport|ammonium transmembrane transport RHCE 6.445658531 5.202069413 7.689247648 1.478113235 0.563756795 0.78195947 1 0.064609002 0.093901368 6006 Rh blood group CcEe antigens "GO:0005887,GO:0008519,GO:0072488" integral component of plasma membrane|ammonium transmembrane transporter activity|ammonium transmembrane transport RHEB 1998.955556 1810.320156 2187.590956 1.208400044 0.273098142 0.248553071 1 36.18481629 42.99404266 6009 "Ras homolog, mTORC1 binding" "GO:0000139,GO:0000287,GO:0003924,GO:0005515,GO:0005525,GO:0005681,GO:0005765,GO:0005789,GO:0005829,GO:0005886,GO:0007050,GO:0007165,GO:0007264,GO:0014069,GO:0016020,GO:0016241,GO:0019003,GO:0019901,GO:0032008,GO:0048714,GO:0070062,GO:0120163,GO:2000074" Golgi membrane|magnesium ion binding|GTPase activity|protein binding|GTP binding|spliceosomal complex|lysosomal membrane|endoplasmic reticulum membrane|cytosol|plasma membrane|cell cycle arrest|signal transduction|small GTPase mediated signal transduction|postsynaptic density|membrane|regulation of macroautophagy|GDP binding|protein kinase binding|positive regulation of TOR signaling|positive regulation of oligodendrocyte differentiation|extracellular exosome|negative regulation of cold-induced thermogenesis|regulation of type B pancreatic cell development "hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04218,hsa04714,hsa04910,hsa04919,hsa05163,hsa05165,hsa05168,hsa05231" Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Cellular senescence|Thermogenesis|Insulin signaling pathway|Thyroid hormone signaling pathway|Human cytomegalovirus infection|Human papillomavirus infection|Herpes simplex virus 1 infection|Choline metabolism in cancer RHEBL1 163.3311171 162.3045657 164.3576685 1.012649692 0.018135186 0.980805881 1 6.979771449 6.949788939 121268 RHEB like 1 "GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005886,GO:0007264,GO:0012505,GO:0019003,GO:0031929,GO:0046872,GO:0051092" GTPase activity|protein binding|GTP binding|cytoplasm|plasma membrane|small GTPase mediated signal transduction|endomembrane system|GDP binding|TOR signaling|metal ion binding|positive regulation of NF-kappaB transcription factor activity RHEX 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.044032495 0.119992321 440712 regulator of hemoglobinization and erythroid cell expansion "GO:0005128,GO:0005515,GO:0005886,GO:0016021,GO:0036018,GO:0038162,GO:0043249,GO:0045648" erythropoietin receptor binding|protein binding|plasma membrane|integral component of membrane|cellular response to erythropoietin|erythropoietin-mediated signaling pathway|erythrocyte maturation|positive regulation of erythrocyte differentiation RHNO1 1415.040679 1444.094469 1385.986889 0.959761926 -0.059251513 0.806978817 1 37.64956897 35.52995884 83695 RAD9-HUS1-RAD1 interacting nuclear orphan 1 "GO:0000077,GO:0000725,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006260,GO:0007049,GO:0034644,GO:0070318,GO:0071479,GO:1901796" DNA damage checkpoint|recombinational repair|protein binding|nucleus|nucleoplasm|chromosome|DNA replication|cell cycle|cellular response to UV|positive regulation of G0 to G1 transition|cellular response to ionizing radiation|regulation of signal transduction by p53 class mediator RHOA 15168.84576 13610.69441 16726.9971 1.22895986 0.297437796 0.258165266 1 356.2421508 430.4811915 387 ras homolog family member A "GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005789,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0005938,GO:0007015,GO:0007163,GO:0007179,GO:0007186,GO:0007266,GO:0008360,GO:0010812,GO:0016032,GO:0016477,GO:0016579,GO:0017022,GO:0019901,GO:0021762,GO:0030027,GO:0030036,GO:0030054,GO:0030334,GO:0030496,GO:0030667,GO:0030865,GO:0031122,GO:0031234,GO:0031410,GO:0031532,GO:0031982,GO:0032154,GO:0032467,GO:0032956,GO:0033688,GO:0034329,GO:0034446,GO:0035385,GO:0036089,GO:0038027,GO:0042995,GO:0043123,GO:0043149,GO:0043197,GO:0043231,GO:0043296,GO:0043297,GO:0043312,GO:0043542,GO:0043931,GO:0044319,GO:0045198,GO:0045666,GO:0045792,GO:0048010,GO:0048013,GO:0048015,GO:0050771,GO:0050772,GO:0050919,GO:0051056,GO:0051496,GO:0051893,GO:0060071,GO:0060193,GO:0061383,GO:0070062,GO:0071222,GO:0071345,GO:0071902,GO:0071944,GO:0090051,GO:0090307,GO:0097498,GO:0098794,GO:0098978,GO:0101003,GO:1901224,GO:1902766,GO:1903673,GO:1904996,GO:1905274,GO:1990869,GO:2000145,GO:2000406" "GTPase activity|protein binding|GTP binding|endosome|endoplasmic reticulum membrane|cytosol|cytoskeleton|plasma membrane|focal adhesion|cell cortex|actin filament organization|establishment or maintenance of cell polarity|transforming growth factor beta receptor signaling pathway|G protein-coupled receptor signaling pathway|Rho protein signal transduction|regulation of cell shape|negative regulation of cell-substrate adhesion|viral process|cell migration|protein deubiquitination|myosin binding|protein kinase binding|substantia nigra development|lamellipodium|actin cytoskeleton organization|cell junction|regulation of cell migration|midbody|secretory granule membrane|cortical cytoskeleton organization|cytoplasmic microtubule organization|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic vesicle|actin cytoskeleton reorganization|vesicle|cleavage furrow|positive regulation of cytokinesis|regulation of actin cytoskeleton organization|regulation of osteoblast proliferation|cell junction assembly|substrate adhesion-dependent cell spreading|Roundabout signaling pathway|cleavage furrow formation|apolipoprotein A-I-mediated signaling pathway|cell projection|positive regulation of I-kappaB kinase/NF-kappaB signaling|stress fiber assembly|dendritic spine|intracellular membrane-bounded organelle|apical junction complex|apical junction assembly|neutrophil degranulation|endothelial cell migration|ossification involved in bone maturation|wound healing, spreading of cells|establishment of epithelial cell apical/basal polarity|positive regulation of neuron differentiation|negative regulation of cell size|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|phosphatidylinositol-mediated signaling|negative regulation of axonogenesis|positive regulation of axonogenesis|negative chemotaxis|regulation of small GTPase mediated signal transduction|positive regulation of stress fiber assembly|regulation of focal adhesion assembly|Wnt signaling pathway, planar cell polarity pathway|positive regulation of lipase activity|trabecula morphogenesis|extracellular exosome|cellular response to lipopolysaccharide|cellular response to cytokine stimulus|positive regulation of protein serine/threonine kinase activity|cell periphery|negative regulation of cell migration involved in sprouting angiogenesis|mitotic spindle assembly|endothelial tube lumen extension|postsynapse|glutamatergic synapse|ficolin-1-rich granule membrane|positive regulation of NIK/NF-kappaB signaling|skeletal muscle satellite cell migration|mitotic cleavage furrow formation|positive regulation of leukocyte adhesion to vascular endothelial cell|regulation of modification of postsynaptic actin cytoskeleton|cellular response to chemokine|regulation of cell motility|positive regulation of T cell migration" "hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04071,hsa04072,hsa04144,hsa04150,hsa04270,hsa04310,hsa04350,hsa04360,hsa04510,hsa04520,hsa04530,hsa04611,hsa04621,hsa04625,hsa04660,hsa04670,hsa04722,hsa04810,hsa04921,hsa04928,hsa04972,hsa05100,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05152,hsa05163,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05418" "Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Endocytosis|mTOR signaling pathway|Vascular smooth muscle contraction|Wnt signaling pathway|TGF-beta signaling pathway|Axon guidance|Focal adhesion|Adherens junction|Tight junction|Platelet activation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|T cell receptor signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Parathyroid hormone synthesis, secretion and action|Pancreatic secretion|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Tuberculosis|Human cytomegalovirus infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Fluid shear stress and atherosclerosis" RHOB 577.784407 672.1073682 483.4614459 0.719321746 -0.475290875 0.0725945 1 15.15383817 10.71808048 388 ras homolog family member B "GO:0000281,GO:0001525,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005769,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0005938,GO:0006886,GO:0006915,GO:0007015,GO:0007155,GO:0007163,GO:0007186,GO:0007266,GO:0008333,GO:0008360,GO:0010008,GO:0010595,GO:0016477,GO:0019003,GO:0019901,GO:0030154,GO:0030334,GO:0030336,GO:0030865,GO:0031410,GO:0031902,GO:0032154,GO:0032956,GO:0042995,GO:0043065,GO:0043231,GO:0045766,GO:0045786,GO:0051056,GO:0061154,GO:0070062,GO:0070301,GO:0071479" mitotic cytokinesis|angiogenesis|GTPase activity|protein binding|GTP binding|nucleus|early endosome|cytosol|cytoskeleton|plasma membrane|focal adhesion|cell cortex|intracellular protein transport|apoptotic process|actin filament organization|cell adhesion|establishment or maintenance of cell polarity|G protein-coupled receptor signaling pathway|Rho protein signal transduction|endosome to lysosome transport|regulation of cell shape|endosome membrane|positive regulation of endothelial cell migration|cell migration|GDP binding|protein kinase binding|cell differentiation|regulation of cell migration|negative regulation of cell migration|cortical cytoskeleton organization|cytoplasmic vesicle|late endosome membrane|cleavage furrow|regulation of actin cytoskeleton organization|cell projection|positive regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of angiogenesis|negative regulation of cell cycle|regulation of small GTPase mediated signal transduction|endothelial tube morphogenesis|extracellular exosome|cellular response to hydrogen peroxide|cellular response to ionizing radiation hsa05132 Salmonella infection RHOBTB1 62.75695592 95.7180772 29.79583464 0.311287434 -1.683680756 0.002811065 0.346318205 0.485533491 0.148611343 9886 Rho related BTB domain containing 1 "GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0007015,GO:0007163,GO:0007264,GO:0008360,GO:0019901,GO:0030865,GO:0031410,GO:0032956,GO:0042995,GO:0043231,GO:0043652,GO:0051056" GTPase activity|protein binding|GTP binding|cytosol|cytoskeleton|plasma membrane|cell cortex|actin filament organization|establishment or maintenance of cell polarity|small GTPase mediated signal transduction|regulation of cell shape|protein kinase binding|cortical cytoskeleton organization|cytoplasmic vesicle|regulation of actin cytoskeleton organization|cell projection|intracellular membrane-bounded organelle|engulfment of apoptotic cell|regulation of small GTPase mediated signal transduction hsa04120 Ubiquitin mediated proteolysis RHOBTB2 428.7668336 469.2266611 388.3070062 0.827546767 -0.27308725 0.337302765 1 2.307784029 1.877841308 23221 Rho related BTB domain containing 2 "GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0007015,GO:0007163,GO:0007264,GO:0008360,GO:0019901,GO:0030865,GO:0031410,GO:0032956,GO:0042995,GO:0043231,GO:0043652,GO:0051056" GTPase activity|protein binding|GTP binding|cytosol|cytoskeleton|plasma membrane|cell cortex|actin filament organization|establishment or maintenance of cell polarity|small GTPase mediated signal transduction|regulation of cell shape|protein kinase binding|cortical cytoskeleton organization|cytoplasmic vesicle|regulation of actin cytoskeleton organization|cell projection|intracellular membrane-bounded organelle|engulfment of apoptotic cell|regulation of small GTPase mediated signal transduction hsa04120 Ubiquitin mediated proteolysis RHOBTB3 3361.989403 3314.75863 3409.220176 1.028497262 0.040537953 0.865413727 1 29.78157842 30.11771575 22836 Rho related BTB domain containing 3 "GO:0003924,GO:0005515,GO:0005524,GO:0005525,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0007015,GO:0007163,GO:0008360,GO:0008584,GO:0016477,GO:0016887,GO:0019901,GO:0030865,GO:0031267,GO:0031410,GO:0032588,GO:0032956,GO:0042147,GO:0042995,GO:0043231,GO:0070062" "GTPase activity|protein binding|ATP binding|GTP binding|cytosol|cytoskeleton|plasma membrane|cell cortex|actin filament organization|establishment or maintenance of cell polarity|regulation of cell shape|male gonad development|cell migration|ATPase activity|protein kinase binding|cortical cytoskeleton organization|small GTPase binding|cytoplasmic vesicle|trans-Golgi network membrane|regulation of actin cytoskeleton organization|retrograde transport, endosome to Golgi|cell projection|intracellular membrane-bounded organelle|extracellular exosome" RHOC 5903.477867 5124.038372 6682.917362 1.304228594 0.383196755 0.11351197 1 223.5981278 286.7431547 389 ras homolog family member C "GO:0000281,GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0007015,GO:0007163,GO:0007186,GO:0007264,GO:0008360,GO:0016477,GO:0019901,GO:0030335,GO:0030865,GO:0031334,GO:0031410,GO:0032154,GO:0032420,GO:0032956,GO:0042995,GO:0043005,GO:0043123,GO:0043231,GO:0043297,GO:0044319,GO:0051056,GO:0051496,GO:0060193,GO:0070062,GO:1902766" "mitotic cytokinesis|GTPase activity|protein binding|GTP binding|cytosol|cytoskeleton|plasma membrane|cell cortex|actin filament organization|establishment or maintenance of cell polarity|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|regulation of cell shape|cell migration|protein kinase binding|positive regulation of cell migration|cortical cytoskeleton organization|positive regulation of protein-containing complex assembly|cytoplasmic vesicle|cleavage furrow|stereocilium|regulation of actin cytoskeleton organization|cell projection|neuron projection|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|apical junction assembly|wound healing, spreading of cells|regulation of small GTPase mediated signal transduction|positive regulation of stress fiber assembly|positive regulation of lipase activity|extracellular exosome|skeletal muscle satellite cell migration" RHOD 364.1718542 363.104445 365.2392633 1.00587935 0.008457272 0.987821411 1 17.55273268 17.36048324 29984 ras homolog family member D "GO:0003924,GO:0005525,GO:0005769,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0007015,GO:0007163,GO:0007266,GO:0008360,GO:0010008,GO:0016477,GO:0019901,GO:0030032,GO:0030335,GO:0030865,GO:0031410,GO:0032956,GO:0042995,GO:0043231,GO:0045785,GO:0048041,GO:0051017,GO:0051056" GTPase activity|GTP binding|early endosome|cytosol|cytoskeleton|plasma membrane|cell cortex|actin filament organization|establishment or maintenance of cell polarity|Rho protein signal transduction|regulation of cell shape|endosome membrane|cell migration|protein kinase binding|lamellipodium assembly|positive regulation of cell migration|cortical cytoskeleton organization|cytoplasmic vesicle|regulation of actin cytoskeleton organization|cell projection|intracellular membrane-bounded organelle|positive regulation of cell adhesion|focal adhesion assembly|actin filament bundle assembly|regulation of small GTPase mediated signal transduction hsa04360 Axon guidance RHOF 2922.553662 3183.666481 2661.440842 0.835967228 -0.258481709 0.274778741 1 69.77676746 57.35499904 54509 "ras homolog family member F, filopodia associated" "GO:0003924,GO:0005525,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0007015,GO:0007163,GO:0007264,GO:0008360,GO:0016477,GO:0019901,GO:0030667,GO:0030865,GO:0031410,GO:0032956,GO:0042995,GO:0043231,GO:0043312,GO:0051056,GO:0070062" GTPase activity|GTP binding|cytosol|cytoskeleton|plasma membrane|cell cortex|actin filament organization|establishment or maintenance of cell polarity|small GTPase mediated signal transduction|regulation of cell shape|cell migration|protein kinase binding|secretory granule membrane|cortical cytoskeleton organization|cytoplasmic vesicle|regulation of actin cytoskeleton organization|cell projection|intracellular membrane-bounded organelle|neutrophil degranulation|regulation of small GTPase mediated signal transduction|extracellular exosome RHOG 1042.803409 1020.646019 1064.960799 1.043418364 0.06131773 0.805671725 1 32.38406787 33.22469903 391 ras homolog family member G "GO:0003924,GO:0005515,GO:0005525,GO:0005789,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0005938,GO:0007015,GO:0007163,GO:0007266,GO:0008045,GO:0008284,GO:0008360,GO:0016601,GO:0019901,GO:0030031,GO:0030036,GO:0030667,GO:0030865,GO:0031410,GO:0032956,GO:0042995,GO:0043231,GO:0043312,GO:0043652,GO:0045893,GO:0051056,GO:0051897,GO:0060326,GO:0070062,GO:0090630,GO:1900027,GO:1902622,GO:1903078" "GTPase activity|protein binding|GTP binding|endoplasmic reticulum membrane|cytosol|cytoskeleton|plasma membrane|focal adhesion|cell cortex|actin filament organization|establishment or maintenance of cell polarity|Rho protein signal transduction|motor neuron axon guidance|positive regulation of cell population proliferation|regulation of cell shape|Rac protein signal transduction|protein kinase binding|cell projection assembly|actin cytoskeleton organization|secretory granule membrane|cortical cytoskeleton organization|cytoplasmic vesicle|regulation of actin cytoskeleton organization|cell projection|intracellular membrane-bounded organelle|neutrophil degranulation|engulfment of apoptotic cell|positive regulation of transcription, DNA-templated|regulation of small GTPase mediated signal transduction|positive regulation of protein kinase B signaling|cell chemotaxis|extracellular exosome|activation of GTPase activity|regulation of ruffle assembly|regulation of neutrophil migration|positive regulation of protein localization to plasma membrane" "hsa05100,hsa05132,hsa05135" Bacterial invasion of epithelial cells|Salmonella infection|Yersinia infection RHOJ 6.926236509 5.202069413 8.650403604 1.662877389 0.733681797 0.660649523 1 0.075978348 0.124228503 57381 ras homolog family member J "GO:0001525,GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005886,GO:0006897,GO:0008360,GO:0010594,GO:0016477,GO:0030031,GO:0030036,GO:0032488,GO:0051056,GO:0061299,GO:0070062,GO:0090050,GO:1903670" angiogenesis|GTPase activity|protein binding|GTP binding|cytosol|plasma membrane|endocytosis|regulation of cell shape|regulation of endothelial cell migration|cell migration|cell projection assembly|actin cytoskeleton organization|Cdc42 protein signal transduction|regulation of small GTPase mediated signal transduction|retina vasculature morphogenesis in camera-type eye|extracellular exosome|positive regulation of cell migration involved in sprouting angiogenesis|regulation of sprouting angiogenesis hsa05132 Salmonella infection RHOQ 1968.672884 2024.645416 1912.700352 0.944708806 -0.082058389 0.730272653 1 30.51443228 28.34486783 23433 ras homolog family member Q "GO:0003924,GO:0005515,GO:0005522,GO:0005525,GO:0005829,GO:0005884,GO:0005886,GO:0006897,GO:0007264,GO:0008286,GO:0008360,GO:0016477,GO:0030031,GO:0030660,GO:0030866,GO:0032427,GO:0032869,GO:0032956,GO:0045121,GO:0045944,GO:0046039,GO:0046326,GO:0051056,GO:0051491,GO:0070062,GO:1903077" GTPase activity|protein binding|profilin binding|GTP binding|cytosol|actin filament|plasma membrane|endocytosis|small GTPase mediated signal transduction|insulin receptor signaling pathway|regulation of cell shape|cell migration|cell projection assembly|Golgi-associated vesicle membrane|cortical actin cytoskeleton organization|GBD domain binding|cellular response to insulin stimulus|regulation of actin cytoskeleton organization|membrane raft|positive regulation of transcription by RNA polymerase II|GTP metabolic process|positive regulation of glucose import|regulation of small GTPase mediated signal transduction|positive regulation of filopodium assembly|extracellular exosome|negative regulation of protein localization to plasma membrane hsa04910 Insulin signaling pathway RHOT1 1123.559402 1172.546446 1074.572359 0.916443321 -0.125882437 0.606892743 1 8.711770675 7.850245232 55288 ras homolog family member T1 "GO:0003674,GO:0003924,GO:0005509,GO:0005515,GO:0005525,GO:0005739,GO:0005741,GO:0005829,GO:0005886,GO:0007005,GO:0010821,GO:0016020,GO:0016579,GO:0019725,GO:0031307,GO:0034640,GO:0046928,GO:0047497,GO:0051056,GO:0097345,GO:1902513" molecular_function|GTPase activity|calcium ion binding|protein binding|GTP binding|mitochondrion|mitochondrial outer membrane|cytosol|plasma membrane|mitochondrion organization|regulation of mitochondrion organization|membrane|protein deubiquitination|cellular homeostasis|integral component of mitochondrial outer membrane|establishment of mitochondrion localization by microtubule attachment|regulation of neurotransmitter secretion|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|mitochondrial outer membrane permeabilization|regulation of organelle transport along microtubule hsa04137 Mitophagy - animal RHOT2 1039.369552 1094.515405 984.2236989 0.899232386 -0.153234099 0.533217552 1 21.35732194 18.88382263 89941 ras homolog family member T2 "GO:0003924,GO:0005509,GO:0005515,GO:0005525,GO:0005739,GO:0005829,GO:0005886,GO:0007005,GO:0010821,GO:0016020,GO:0019725,GO:0031307,GO:0047497,GO:0051056,GO:0097345" GTPase activity|calcium ion binding|protein binding|GTP binding|mitochondrion|cytosol|plasma membrane|mitochondrion organization|regulation of mitochondrion organization|membrane|cellular homeostasis|integral component of mitochondrial outer membrane|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|mitochondrial outer membrane permeabilization hsa04137 Mitophagy - animal RHOU 13.01020395 13.52538047 12.49502743 0.923820772 -0.11431511 0.99665641 1 0.182049104 0.165366467 58480 ras homolog family member U "GO:0000139,GO:0002102,GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005886,GO:0005925,GO:0006897,GO:0007010,GO:0008360,GO:0016477,GO:0019221,GO:0030031,GO:0032488,GO:0042995,GO:0046872,GO:0051056,GO:1903955" Golgi membrane|podosome|GTPase activity|protein binding|GTP binding|cytosol|plasma membrane|focal adhesion|endocytosis|cytoskeleton organization|regulation of cell shape|cell migration|cytokine-mediated signaling pathway|cell projection assembly|Cdc42 protein signal transduction|cell projection|metal ion binding|regulation of small GTPase mediated signal transduction|positive regulation of protein targeting to mitochondrion RHOV 7.525701377 8.323311061 6.728091692 0.808343175 -0.306960188 0.918003413 1 0.269212008 0.213974186 171177 ras homolog family member V "GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005886,GO:0006897,GO:0010008,GO:0016477,GO:0030031,GO:0032488,GO:0046872,GO:0051056" GTPase activity|protein binding|GTP binding|cytosol|plasma membrane|endocytosis|endosome membrane|cell migration|cell projection assembly|Cdc42 protein signal transduction|metal ion binding|regulation of small GTPase mediated signal transduction RHPN1 113.1333553 106.122216 120.1444945 1.132133299 0.179043833 0.703658538 1 0.957650934 1.066046085 114822 rhophilin Rho GTPase binding protein 1 "GO:0005515,GO:0005829,GO:0007165" protein binding|cytosol|signal transduction RHPN2 449.7298255 325.6495453 573.8101057 1.762047926 0.817253164 0.003679854 0.381043789 4.964101032 8.600614996 85415 rhophilin Rho GTPase binding protein 2 "GO:0005829,GO:0007165,GO:0048471" cytosol|signal transduction|perinuclear region of cytoplasm RIBC1 20.61516325 23.9295193 17.30080721 0.722990169 -0.467952065 0.608529082 1 0.787345539 0.559717572 158787 RIB43A domain with coiled-coils 1 GO:0005515 protein binding RIBC2 110.2102584 105.0818021 115.3387147 1.097608838 0.134364003 0.783267151 1 2.96720775 3.202334753 26150 RIB43A domain with coiled-coils 2 "GO:0005515,GO:0005634" protein binding|nucleus RIC1 805.418624 869.7860059 741.0512421 0.851992602 -0.231087192 0.358824266 1 5.311692475 4.449794197 57589 "RIC1 homolog, RAB6A GEF complex partner 1" "GO:0000139,GO:0003330,GO:0005085,GO:0005515,GO:0005829,GO:0006886,GO:0016020,GO:0031267,GO:0032588,GO:0032991,GO:0034066,GO:0042147,GO:0043547,GO:1903363,GO:1904888" "Golgi membrane|regulation of extracellular matrix constituent secretion|guanyl-nucleotide exchange factor activity|protein binding|cytosol|intracellular protein transport|membrane|small GTPase binding|trans-Golgi network membrane|protein-containing complex|RIC1-RGP1 guanyl-nucleotide exchange factor complex|retrograde transport, endosome to Golgi|positive regulation of GTPase activity|negative regulation of cellular protein catabolic process|cranial skeletal system development" RIC8A 3723.555806 3584.225826 3862.885787 1.077746207 0.108017485 0.650052152 1 52.84075823 55.99596357 60626 RIC8 guanine nucleotide exchange factor A "GO:0001701,GO:0001944,GO:0001965,GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005886,GO:0007186,GO:0007193,GO:0008542,GO:0042074,GO:0043547,GO:0070586,GO:0071711" in utero embryonic development|vasculature development|G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytoplasm|plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|visual learning|cell migration involved in gastrulation|positive regulation of GTPase activity|cell-cell adhesion involved in gastrulation|basement membrane organization RIC8B 491.5489417 502.5199053 480.577978 0.956336203 -0.064410204 0.821032128 1 5.03162547 4.731404537 55188 RIC8 guanine nucleotide exchange factor B "GO:0001965,GO:0005085,GO:0005096,GO:0005737,GO:0005829,GO:0005886,GO:0005938,GO:0007186,GO:0008277,GO:0043547" G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|cytoplasm|cytosol|plasma membrane|cell cortex|G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|positive regulation of GTPase activity RICTOR 1621.340766 1712.521251 1530.160282 0.893513164 -0.16243911 0.495439927 1 9.422073369 8.277870268 253260 RPTOR independent companion of MTOR complex 2 "GO:0001938,GO:0005515,GO:0005829,GO:0009792,GO:0010468,GO:0016032,GO:0018105,GO:0019901,GO:0030838,GO:0031532,GO:0031932,GO:0032008,GO:0032148,GO:0032956,GO:0033135,GO:0038203,GO:0043022,GO:0043087,GO:0043539,GO:0050727,GO:0050731,GO:0051896,GO:0051897,GO:0071902,GO:2000114" positive regulation of endothelial cell proliferation|protein binding|cytosol|embryo development ending in birth or egg hatching|regulation of gene expression|viral process|peptidyl-serine phosphorylation|protein kinase binding|positive regulation of actin filament polymerization|actin cytoskeleton reorganization|TORC2 complex|positive regulation of TOR signaling|activation of protein kinase B activity|regulation of actin cytoskeleton organization|regulation of peptidyl-serine phosphorylation|TORC2 signaling|ribosome binding|regulation of GTPase activity|protein serine/threonine kinase activator activity|regulation of inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|regulation of protein kinase B signaling|positive regulation of protein kinase B signaling|positive regulation of protein serine/threonine kinase activity|regulation of establishment of cell polarity hsa04150 mTOR signaling pathway RIDA 287.7159107 273.6288511 301.8029702 1.102964724 0.14138665 0.665850658 1 14.7954092 16.04574116 10247 reactive intermediate imine deaminase A homolog "GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0005829,GO:0006402,GO:0016892,GO:0017148,GO:0019239,GO:0019518,GO:0061157,GO:0070062,GO:0090502,GO:0120241,GO:1901565" "RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|mitochondrion|mitochondrial matrix|peroxisome|cytosol|mRNA catabolic process|endoribonuclease activity, producing 3'-phosphomonoesters|negative regulation of translation|deaminase activity|L-threonine catabolic process to glycine|mRNA destabilization|extracellular exosome|RNA phosphodiester bond hydrolysis, endonucleolytic|2-iminobutanoate/2-iminopropanoate deaminase|organonitrogen compound catabolic process" RIF1 1929.760545 2088.110662 1771.410427 0.84833168 -0.237299656 0.316334333 1 11.18300334 9.328145656 55183 replication timing regulatory factor 1 "GO:0000122,GO:0000723,GO:0000781,GO:0000785,GO:0000793,GO:0001939,GO:0001940,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0006303,GO:0006348,GO:0006974,GO:0007049,GO:0016604,GO:0019827,GO:0031965,GO:0035861,GO:0043247,GO:0045830,GO:0051233,GO:0051574,GO:1990830,GO:2000042,GO:2001034" "negative regulation of transcription by RNA polymerase II|telomere maintenance|chromosome, telomeric region|chromatin|condensed chromosome|female pronucleus|male pronucleus|protein binding|nucleus|nucleoplasm|cytoplasm|plasma membrane|double-strand break repair via nonhomologous end joining|chromatin silencing at telomere|cellular response to DNA damage stimulus|cell cycle|nuclear body|stem cell population maintenance|nuclear membrane|site of double-strand break|telomere maintenance in response to DNA damage|positive regulation of isotype switching|spindle midzone|positive regulation of histone H3-K9 methylation|cellular response to leukemia inhibitory factor|negative regulation of double-strand break repair via homologous recombination|positive regulation of double-strand break repair via nonhomologous end joining" hsa04550 Signaling pathways regulating pluripotency of stem cells RILP 131.6230314 137.3346325 125.9114302 0.91682213 -0.125286228 0.783089481 1 4.698267261 4.235395628 83547 Rab interacting lysosomal protein "GO:0005515,GO:0005737,GO:0005764,GO:0005765,GO:0005770,GO:0005829,GO:0008333,GO:0010796,GO:0015031,GO:0019886,GO:0030670,GO:0031267,GO:0031902,GO:0032509,GO:0032991,GO:0036064,GO:0042177,GO:0045022,GO:0045732,GO:0046983,GO:0051959,GO:0060271,GO:0070676" protein binding|cytoplasm|lysosome|lysosomal membrane|late endosome|cytosol|endosome to lysosome transport|regulation of multivesicular body size|protein transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|phagocytic vesicle membrane|small GTPase binding|late endosome membrane|endosome transport via multivesicular body sorting pathway|protein-containing complex|ciliary basal body|negative regulation of protein catabolic process|early endosome to late endosome transport|positive regulation of protein catabolic process|protein dimerization activity|dynein light intermediate chain binding|cilium assembly|intralumenal vesicle formation "hsa04145,hsa05132" Phagosome|Salmonella infection RILPL1 375.39311 443.216314 307.5699059 0.693949875 -0.527096635 0.073080895 1 4.781410973 3.262536316 353116 Rab interacting lysosomal protein like 1 "GO:0003382,GO:0005515,GO:0005654,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0005929,GO:0036064,GO:0046983,GO:0060271,GO:1901214,GO:1903445" epithelial cell morphogenesis|protein binding|nucleoplasm|cytoplasm|centrosome|centriole|cytosol|plasma membrane|cilium|ciliary basal body|protein dimerization activity|cilium assembly|regulation of neuron death|protein transport from ciliary membrane to plasma membrane RILPL2 373.4022153 315.2454064 431.5590242 1.368962134 0.453082541 0.12439107 1 6.697479278 9.015171493 196383 Rab interacting lysosomal protein like 2 "GO:0003382,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005929,GO:0016020,GO:0036064,GO:0042802,GO:0046983,GO:0060271,GO:1903445" epithelial cell morphogenesis|protein binding|cytoplasm|centrosome|cytosol|cilium|membrane|ciliary basal body|identical protein binding|protein dimerization activity|cilium assembly|protein transport from ciliary membrane to plasma membrane RIMBP3 3.443303773 2.080827765 4.80577978 2.309551929 1.207612985 0.648665767 1 0.018190001 0.041307758 85376 RIMS binding protein 3 "GO:0002177,GO:0005515,GO:0005634,GO:0005737,GO:0007274,GO:0007286,GO:0009566,GO:0030156,GO:0045202" manchette|protein binding|nucleus|cytoplasm|neuromuscular synaptic transmission|spermatid development|fertilization|benzodiazepine receptor binding|synapse RIMKLB 814.6093562 820.8865534 808.332159 0.984706298 -0.02223461 0.934611544 1 7.364129539 7.130160625 57494 ribosomal modification protein rimK like family member B "GO:0005524,GO:0005737,GO:0005829,GO:0006464,GO:0008652,GO:0016879,GO:0046872,GO:0072590,GO:0072591" "ATP binding|cytoplasm|cytosol|cellular protein modification process|cellular amino acid biosynthetic process|ligase activity, forming carbon-nitrogen bonds|metal ion binding|N-acetyl-L-aspartate-L-glutamate ligase activity|citrate-L-glutamate ligase activity" hsa00250 "Alanine, aspartate and glutamate metabolism" RIMS1 348.6694416 372.46817 324.8707131 0.872210673 -0.197251451 0.515697428 1 1.372312162 1.176916055 22999 regulating synaptic membrane exocytosis 1 "GO:0003723,GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0007269,GO:0007601,GO:0010628,GO:0014047,GO:0016079,GO:0017156,GO:0030154,GO:0030695,GO:0031267,GO:0042391,GO:0042734,GO:0042995,GO:0044325,GO:0045055,GO:0046872,GO:0046903,GO:0046928,GO:0048167,GO:0048786,GO:0048788,GO:0048791,GO:0050790,GO:0050806,GO:0050896,GO:0060478,GO:0061025,GO:0065003,GO:0097151,GO:1903861,GO:2000300,GO:2000463" RNA binding|protein binding|cytosol|plasma membrane|intracellular protein transport|neurotransmitter secretion|visual perception|positive regulation of gene expression|glutamate secretion|synaptic vesicle exocytosis|calcium-ion regulated exocytosis|cell differentiation|GTPase regulator activity|small GTPase binding|regulation of membrane potential|presynaptic membrane|cell projection|ion channel binding|regulated exocytosis|metal ion binding|secretion|regulation of neurotransmitter secretion|regulation of synaptic plasticity|presynaptic active zone|cytoskeleton of presynaptic active zone|calcium ion-regulated exocytosis of neurotransmitter|regulation of catalytic activity|positive regulation of synaptic transmission|response to stimulus|acrosomal vesicle exocytosis|membrane fusion|protein-containing complex assembly|positive regulation of inhibitory postsynaptic potential|positive regulation of dendrite extension|regulation of synaptic vesicle exocytosis|positive regulation of excitatory postsynaptic potential "hsa04721,hsa04723" Synaptic vesicle cycle|Retrograde endocannabinoid signaling RIMS2 235.3530327 223.6889848 247.0170807 1.104288085 0.14311659 0.684361295 1 1.03546448 1.124316983 9699 regulating synaptic membrane exocytosis 2 "GO:0005515,GO:0006886,GO:0010628,GO:0017156,GO:0017157,GO:0019933,GO:0030073,GO:0030154,GO:0042391,GO:0042734,GO:0042995,GO:0044325,GO:0046872,GO:0048167,GO:0048786,GO:0048788,GO:0048791,GO:0050806,GO:0061669,GO:0070062,GO:0097151,GO:1903861,GO:2000300,GO:2000463" protein binding|intracellular protein transport|positive regulation of gene expression|calcium-ion regulated exocytosis|regulation of exocytosis|cAMP-mediated signaling|insulin secretion|cell differentiation|regulation of membrane potential|presynaptic membrane|cell projection|ion channel binding|metal ion binding|regulation of synaptic plasticity|presynaptic active zone|cytoskeleton of presynaptic active zone|calcium ion-regulated exocytosis of neurotransmitter|positive regulation of synaptic transmission|spontaneous neurotransmitter secretion|extracellular exosome|positive regulation of inhibitory postsynaptic potential|positive regulation of dendrite extension|regulation of synaptic vesicle exocytosis|positive regulation of excitatory postsynaptic potential hsa04911 Insulin secretion RIMS3 305.6161827 276.7500928 334.4822727 1.208607626 0.27334595 0.384826985 1 1.993742415 2.369330019 9783 regulating synaptic membrane exocytosis 3 "GO:0005515,GO:0017156,GO:0042391,GO:0042734,GO:0044325,GO:0048167,GO:0048786,GO:0048788,GO:0048791,GO:0050806,GO:2000300" protein binding|calcium-ion regulated exocytosis|regulation of membrane potential|presynaptic membrane|ion channel binding|regulation of synaptic plasticity|presynaptic active zone|cytoskeleton of presynaptic active zone|calcium ion-regulated exocytosis of neurotransmitter|positive regulation of synaptic transmission|regulation of synaptic vesicle exocytosis RIN1 416.2422381 443.216314 389.2681622 0.878280311 -0.187246632 0.516240123 1 5.453917473 4.709913029 9610 Ras and Rab interactor 1 "GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006897,GO:0007165,GO:0043547" GTPase activator activity|protein binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|endocytosis|signal transduction|positive regulation of GTPase activity hsa04014 Ras signaling pathway RIN2 2133.757736 2207.758259 2059.757214 0.932963202 -0.100107916 0.673165406 1 12.96764259 11.89588413 54453 Ras and Rab interactor 2 "GO:0005085,GO:0005096,GO:0005575,GO:0005829,GO:0006897,GO:0007264,GO:0010595,GO:0030695,GO:0043547,GO:1904906,GO:2001214" guanyl-nucleotide exchange factor activity|GTPase activator activity|cellular_component|cytosol|endocytosis|small GTPase mediated signal transduction|positive regulation of endothelial cell migration|GTPase regulator activity|positive regulation of GTPase activity|positive regulation of endothelial cell-matrix adhesion via fibronectin|positive regulation of vasculogenesis RIN3 368.2095924 380.791481 355.6277037 0.933917174 -0.098633488 0.746065527 1 3.772441336 3.464192644 79890 Ras and Rab interactor 3 "GO:0002091,GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005769,GO:0005829,GO:0006897,GO:0007165,GO:0030139,GO:0030424,GO:0030425,GO:0031267,GO:0031410,GO:0031982,GO:0043025,GO:0043547,GO:0060755,GO:0097494" negative regulation of receptor internalization|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytoplasm|early endosome|cytosol|endocytosis|signal transduction|endocytic vesicle|axon|dendrite|small GTPase binding|cytoplasmic vesicle|vesicle|neuronal cell body|positive regulation of GTPase activity|negative regulation of mast cell chemotaxis|regulation of vesicle size RING1 512.0898774 511.8836303 512.2961245 1.000805836 0.001162108 1 1 15.69114793 15.44101072 6015 ring finger protein 1 "GO:0000151,GO:0001739,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0009952,GO:0016607,GO:0031519,GO:0035102,GO:0035518,GO:0045892,GO:0046872,GO:0048593,GO:0050790,GO:0061630,GO:0070317,GO:0097027" "ubiquitin ligase complex|sex chromatin|chromatin binding|protein binding|nucleus|nucleoplasm|cytosol|anterior/posterior pattern specification|nuclear speck|PcG protein complex|PRC1 complex|histone H2A monoubiquitination|negative regulation of transcription, DNA-templated|metal ion binding|camera-type eye morphogenesis|regulation of catalytic activity|ubiquitin protein ligase activity|negative regulation of G0 to G1 transition|ubiquitin-protein transferase activator activity" other RINL 10.5676851 12.48496659 8.650403604 0.692865579 -0.529352609 0.69159681 1 0.204700375 0.139456513 126432 Ras and Rab interactor like "GO:0001726,GO:0005085,GO:0005096,GO:0006897,GO:0015031,GO:0015629,GO:0031410,GO:0043547" ruffle|guanyl-nucleotide exchange factor activity|GTPase activator activity|endocytosis|protein transport|actin cytoskeleton|cytoplasmic vesicle|positive regulation of GTPase activity RINT1 658.3384538 629.450399 687.2265085 1.091788185 0.12669299 0.627781353 1 11.60767481 12.46105468 60561 RAD50 interactor 1 "GO:0005515,GO:0005783,GO:0005789,GO:0005829,GO:0006890,GO:0007049,GO:0015031,GO:0060628,GO:0070939,GO:1902504" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|cell cycle|protein transport|regulation of ER to Golgi vesicle-mediated transport|Dsl1/NZR complex|regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" RIOK1 400.036565 408.8826559 391.1904741 0.956730418 -0.063815628 0.833239726 1 7.990229165 7.51657501 83732 RIO kinase 1 "GO:0004674,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006468,GO:0016787,GO:0030490,GO:0030688,GO:0034708,GO:0042274,GO:0046872,GO:0106310,GO:0106311,GO:2000234" "protein serine/threonine kinase activity|protein binding|ATP binding|nucleoplasm|cytosol|protein phosphorylation|hydrolase activity|maturation of SSU-rRNA|preribosome, small subunit precursor|methyltransferase complex|ribosomal small subunit biogenesis|metal ion binding|protein serine kinase activity|protein threonine kinase activity|positive regulation of rRNA processing" hsa03008 Ribosome biogenesis in eukaryotes RIOK2 566.0184066 552.4597717 579.5770415 1.049084605 0.069131031 0.800716086 1 6.234671735 6.431248411 55781 RIO kinase 2 "GO:0004672,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007049,GO:0030071,GO:0030490,GO:0030688,GO:0042274,GO:0046777,GO:0046872,GO:0106310,GO:0106311,GO:2000208,GO:2000234" "protein kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|cell cycle|regulation of mitotic metaphase/anaphase transition|maturation of SSU-rRNA|preribosome, small subunit precursor|ribosomal small subunit biogenesis|protein autophosphorylation|metal ion binding|protein serine kinase activity|protein threonine kinase activity|positive regulation of ribosomal small subunit export from nucleus|positive regulation of rRNA processing" hsa03008 Ribosome biogenesis in eukaryotes RIOK3 3036.372613 2979.74536 3092.999866 1.038008116 0.053817724 0.821342319 1 39.38175664 40.19453528 8780 RIO kinase 3 "GO:0004674,GO:0005515,GO:0005524,GO:0005829,GO:0006468,GO:0007059,GO:0030490,GO:0030688,GO:0031333,GO:0032728,GO:0039534,GO:0043124,GO:0045087,GO:0045089,GO:0046872,GO:0051607,GO:0071359,GO:0089720,GO:0098586,GO:0106310,GO:0106311,GO:1990786" "protein serine/threonine kinase activity|protein binding|ATP binding|cytosol|protein phosphorylation|chromosome segregation|maturation of SSU-rRNA|preribosome, small subunit precursor|negative regulation of protein-containing complex assembly|positive regulation of interferon-beta production|negative regulation of MDA-5 signaling pathway|negative regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of innate immune response|metal ion binding|defense response to virus|cellular response to dsRNA|caspase binding|cellular response to virus|protein serine kinase activity|protein threonine kinase activity|cellular response to dsDNA" RIOX1 192.1903335 200.7998793 183.5807876 0.914247499 -0.129343319 0.736680135 1 4.352689077 3.912844647 79697 ribosomal oxygenase 1 "GO:0005506,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0016706,GO:0032453,GO:0034720,GO:0045668,GO:0045892,GO:0051864,GO:0055114,GO:0070544" "iron ion binding|protein binding|nucleus|nucleoplasm|nucleolus|2-oxoglutarate-dependent dioxygenase activity|histone demethylase activity (H3-K4 specific)|histone H3-K4 demethylation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|histone H3-K36 demethylation" RIOX2 619.7280549 738.6938567 500.7622531 0.677902285 -0.560850762 0.031863492 0.911575844 6.324840922 4.215876528 84864 ribosomal oxygenase 2 "GO:0003714,GO:0005515,GO:0005654,GO:0005667,GO:0005730,GO:0005829,GO:0016706,GO:0032453,GO:0034720,GO:0042254,GO:0042802,GO:0045892,GO:0046872,GO:0051864,GO:0055114,GO:0070544" "transcription corepressor activity|protein binding|nucleoplasm|transcription regulator complex|nucleolus|cytosol|2-oxoglutarate-dependent dioxygenase activity|histone demethylase activity (H3-K4 specific)|histone H3-K4 demethylation|ribosome biogenesis|identical protein binding|negative regulation of transcription, DNA-templated|metal ion binding|histone demethylase activity (H3-K36 specific)|oxidation-reduction process|histone H3-K36 demethylation" RIPK1 920.5535491 977.9890497 863.1180485 0.882543673 -0.180260422 0.468226758 1 10.70415876 9.288806723 8737 receptor interacting serine/threonine kinase 1 "GO:0001934,GO:0002756,GO:0004672,GO:0004674,GO:0004706,GO:0005123,GO:0005515,GO:0005524,GO:0005739,GO:0005829,GO:0005886,GO:0006915,GO:0006919,GO:0006954,GO:0007249,GO:0007256,GO:0007257,GO:0008219,GO:0010008,GO:0010803,GO:0010940,GO:0016032,GO:0016579,GO:0031264,GO:0031625,GO:0032757,GO:0032760,GO:0032991,GO:0033209,GO:0034138,GO:0034612,GO:0035666,GO:0036289,GO:0042802,GO:0042803,GO:0043065,GO:0043066,GO:0043068,GO:0043123,GO:0043124,GO:0043235,GO:0044257,GO:0044877,GO:0045121,GO:0045651,GO:0045944,GO:0046330,GO:0046777,GO:0050729,GO:0051092,GO:0060545,GO:0060546,GO:0070105,GO:0070231,GO:0070266,GO:0070301,GO:0070513,GO:0070926,GO:0071356,GO:0071550,GO:0097190,GO:0097191,GO:0097300,GO:0097342,GO:0097343,GO:0097527,GO:0106310,GO:0106311,GO:1902041,GO:1902042,GO:1903800,GO:1905206,GO:1990000,GO:2000379,GO:2001237,GO:2001238" positive regulation of protein phosphorylation|MyD88-independent toll-like receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|JUN kinase kinase kinase activity|death receptor binding|protein binding|ATP binding|mitochondrion|cytosol|plasma membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|I-kappaB kinase/NF-kappaB signaling|activation of JNKK activity|activation of JUN kinase activity|cell death|endosome membrane|regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of necrotic cell death|viral process|protein deubiquitination|death-inducing signaling complex|ubiquitin protein ligase binding|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|protein-containing complex|tumor necrosis factor-mediated signaling pathway|toll-like receptor 3 signaling pathway|response to tumor necrosis factor|TRIF-dependent toll-like receptor signaling pathway|peptidyl-serine autophosphorylation|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of programmed cell death|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|receptor complex|cellular protein catabolic process|protein-containing complex binding|membrane raft|positive regulation of macrophage differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|protein autophosphorylation|positive regulation of inflammatory response|positive regulation of NF-kappaB transcription factor activity|positive regulation of necroptotic process|negative regulation of necroptotic process|positive regulation of interleukin-6-mediated signaling pathway|T cell apoptotic process|necroptotic process|cellular response to hydrogen peroxide|death domain binding|regulation of ATP:ADP antiporter activity|cellular response to tumor necrosis factor|death-inducing signaling complex assembly|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|programmed necrotic cell death|ripoptosome|ripoptosome assembly|necroptotic signaling pathway|protein serine kinase activity|protein threonine kinase activity|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of production of miRNAs involved in gene silencing by miRNA|positive regulation of hydrogen peroxide-induced cell death|amyloid fibril formation|positive regulation of reactive oxygen species metabolic process|negative regulation of extrinsic apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway "hsa04064,hsa04210,hsa04217,hsa04620,hsa04621,hsa04622,hsa04623,hsa04668,hsa05130,hsa05131,hsa05132,hsa05160,hsa05163,hsa05169,hsa05170" NF-kappa B signaling pathway|Apoptosis|Necroptosis|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|TNF signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Hepatitis C|Human cytomegalovirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection RIPK2 3078.180939 2487.629593 3668.732284 1.474790416 0.560509947 0.018156738 0.773499658 50.28796187 72.92316671 8767 receptor interacting serine/threonine kinase 2 "GO:0000187,GO:0001961,GO:0002250,GO:0002827,GO:0004672,GO:0004674,GO:0004706,GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005856,GO:0006915,GO:0006954,GO:0007165,GO:0007249,GO:0007254,GO:0007256,GO:0007257,GO:0010800,GO:0010942,GO:0018108,GO:0030274,GO:0031398,GO:0031663,GO:0031982,GO:0032092,GO:0032722,GO:0032727,GO:0032728,GO:0032729,GO:0032731,GO:0032735,GO:0032743,GO:0032755,GO:0032760,GO:0032991,GO:0033091,GO:0033138,GO:0034134,GO:0034142,GO:0042098,GO:0042802,GO:0042803,GO:0043065,GO:0043066,GO:0043123,GO:0043330,GO:0045087,GO:0045627,GO:0045944,GO:0046330,GO:0046641,GO:0050700,GO:0050731,GO:0050830,GO:0050852,GO:0051092,GO:0070374,GO:0070423,GO:0070427,GO:0070431,GO:0070498,GO:0070671,GO:0070673,GO:0071223,GO:0071224,GO:0071225,GO:0089720,GO:0097202,GO:0106310,GO:0106311,GO:1904417" activation of MAPK activity|positive regulation of cytokine-mediated signaling pathway|adaptive immune response|positive regulation of T-helper 1 type immune response|protein kinase activity|protein serine/threonine kinase activity|JUN kinase kinase kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|protein binding|ATP binding|cytoplasm|cytosol|cytoskeleton|apoptotic process|inflammatory response|signal transduction|I-kappaB kinase/NF-kappaB signaling|JNK cascade|activation of JNKK activity|activation of JUN kinase activity|positive regulation of peptidyl-threonine phosphorylation|positive regulation of cell death|peptidyl-tyrosine phosphorylation|LIM domain binding|positive regulation of protein ubiquitination|lipopolysaccharide-mediated signaling pathway|vesicle|positive regulation of protein binding|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-2 production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|protein-containing complex|positive regulation of immature T cell proliferation|positive regulation of peptidyl-serine phosphorylation|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway|T cell proliferation|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to exogenous dsRNA|innate immune response|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|positive regulation of alpha-beta T cell proliferation|CARD domain binding|positive regulation of peptidyl-tyrosine phosphorylation|defense response to Gram-positive bacterium|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of ERK1 and ERK2 cascade|nucleotide-binding oligomerization domain containing signaling pathway|nucleotide-binding oligomerization domain containing 1 signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|interleukin-1-mediated signaling pathway|response to interleukin-12|response to interleukin-18|cellular response to lipoteichoic acid|cellular response to peptidoglycan|cellular response to muramyl dipeptide|caspase binding|activation of cysteine-type endopeptidase activity|protein serine kinase activity|protein threonine kinase activity|positive regulation of xenophagy "hsa04621,hsa04722,hsa05131,hsa05132,hsa05152" NOD-like receptor signaling pathway|Neurotrophin signaling pathway|Shigellosis|Salmonella infection|Tuberculosis RIPK4 148.8445807 135.2538047 162.4353566 1.200967003 0.264196513 0.523337678 1 1.884167834 2.224958113 54101 receptor interacting serine/threonine kinase 4 "GO:0002009,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0016020,GO:0051092,GO:0106310,GO:0106311" morphogenesis of an epithelium|protein binding|ATP binding|cytoplasm|protein phosphorylation|membrane|positive regulation of NF-kappaB transcription factor activity|protein serine kinase activity|protein threonine kinase activity RIPOR1 2597.319913 2593.751809 2600.888017 1.002751307 0.003963847 0.988476494 1 24.40905783 24.06663834 79567 RHO family interacting cell polarization regulator 1 "GO:0005515,GO:0005737,GO:0005794,GO:0007266,GO:0009267,GO:0009611,GO:0012506,GO:0016020,GO:0030335,GO:0034067,GO:0051683,GO:0070062,GO:0071889,GO:0090316" protein binding|cytoplasm|Golgi apparatus|Rho protein signal transduction|cellular response to starvation|response to wounding|vesicle membrane|membrane|positive regulation of cell migration|protein localization to Golgi apparatus|establishment of Golgi localization|extracellular exosome|14-3-3 protein binding|positive regulation of intracellular protein transport RIPOR2 4.964295633 4.161655531 5.766935736 1.385731158 0.470647391 0.897151737 1 0.025164277 0.034287405 9750 RHO family interacting cell polarization regulator 2 "GO:0005515,GO:0005737,GO:0005856,GO:0006935,GO:0007155,GO:0007162,GO:0007605,GO:0016324,GO:0030175,GO:0032420,GO:0035024,GO:0042802,GO:0045184,GO:0045663,GO:0048741,GO:0051260,GO:0051491,GO:0060088,GO:0060171,GO:0071260,GO:0071889,GO:0090023,GO:1901741,GO:1903904,GO:1905872,GO:1990869,GO:2000114,GO:2000391,GO:2000405,GO:2001107" protein binding|cytoplasm|cytoskeleton|chemotaxis|cell adhesion|negative regulation of cell adhesion|sensory perception of sound|apical plasma membrane|filopodium|stereocilium|negative regulation of Rho protein signal transduction|identical protein binding|establishment of protein localization|positive regulation of myoblast differentiation|skeletal muscle fiber development|protein homooligomerization|positive regulation of filopodium assembly|auditory receptor cell stereocilium organization|stereocilium membrane|cellular response to mechanical stimulus|14-3-3 protein binding|positive regulation of neutrophil chemotaxis|positive regulation of myoblast fusion|negative regulation of establishment of T cell polarity|negative regulation of protein localization to cell leading edge|cellular response to chemokine|regulation of establishment of cell polarity|positive regulation of neutrophil extravasation|negative regulation of T cell migration|negative regulation of Rho guanyl-nucleotide exchange factor activity RIPOR3 18.9752845 18.72744989 19.22311912 1.026467524 0.037687984 1 1 0.158040731 0.159509084 140876 RIPOR family member 3 GO:0005515 protein binding RIPPLY2 8.967435311 8.323311061 9.61155956 1.154775965 0.207612985 0.965671908 1 0.668975623 0.759589945 134701 ripply transcriptional repressor 2 "GO:0000122,GO:0001503,GO:0001756,GO:0005515,GO:0005634,GO:0007219,GO:0007368,GO:0009880,GO:0032525,GO:0036342,GO:0060349" negative regulation of transcription by RNA polymerase II|ossification|somitogenesis|protein binding|nucleus|Notch signaling pathway|determination of left/right symmetry|embryonic pattern specification|somite rostral/caudal axis specification|post-anal tail morphogenesis|bone morphogenesis RIPPLY3 28.46292676 28.09117483 28.83467868 1.026467524 0.037687984 1 1 0.686749598 0.693130174 53820 ripply transcriptional repressor 3 "GO:0000122,GO:0005515,GO:0005634,GO:0007507,GO:0008150,GO:0008285,GO:0009880,GO:0060037" negative regulation of transcription by RNA polymerase II|protein binding|nucleus|heart development|biological_process|negative regulation of cell population proliferation|embryonic pattern specification|pharyngeal system development RIT1 475.8339074 443.216314 508.4515007 1.147185888 0.198099182 0.476566505 1 6.89409504 7.776465339 6016 Ras like without CAAX 1 "GO:0003924,GO:0005515,GO:0005516,GO:0005525,GO:0005886,GO:0007165,GO:0007265,GO:0019003" GTPase activity|protein binding|calmodulin binding|GTP binding|plasma membrane|signal transduction|Ras protein signal transduction|GDP binding RITA1 453.5090539 487.954111 419.0639968 0.858818457 -0.219574898 0.434873442 1 12.89807532 10.8917448 84934 RBPJ interacting and tubulin associated 1 "GO:0000122,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0007219,GO:0015631,GO:0022008,GO:0045746,GO:0051168" negative regulation of transcription by RNA polymerase II|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|Notch signaling pathway|tubulin binding|neurogenesis|negative regulation of Notch signaling pathway|nuclear export RLF 932.0628828 939.493736 924.6320297 0.984181154 -0.023004204 0.930490764 1 7.882259704 7.627759002 6018 RLF zinc finger "GO:0000981,GO:0001228,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0044030,GO:0045893,GO:0045944,GO:0046872,GO:0097692" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|regulation of DNA methylation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|histone H3-K4 monomethylation" RLIM 3121.320444 3065.059298 3177.581591 1.036711294 0.052014184 0.827317697 1 15.39254554 15.69059654 51132 "ring finger protein, LIM domain interacting" "GO:0000122,GO:0000209,GO:0003714,GO:0004842,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0016567,GO:0017053,GO:0043433,GO:0045892,GO:0046872,GO:0060816,GO:0061630,GO:1900095" "negative regulation of transcription by RNA polymerase II|protein polyubiquitination|transcription corepressor activity|ubiquitin-protein transferase activity|nucleus|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|transcription repressor complex|negative regulation of DNA-binding transcription factor activity|negative regulation of transcription, DNA-templated|metal ion binding|random inactivation of X chromosome|ubiquitin protein ligase activity|regulation of dosage compensation by inactivation of X chromosome" RLN1 3.121241648 6.242483296 0 0 #NAME? 0.093640883 1 0.330178256 0 6013 relaxin 1 "GO:0005179,GO:0005515,GO:0005576,GO:0007165,GO:0007565" hormone activity|protein binding|extracellular region|signal transduction|female pregnancy "hsa04080,hsa04926" Neuroactive ligand-receptor interaction|Relaxin signaling pathway RLN2 29.98391862 30.1720026 29.79583464 0.987532549 -0.018099795 1 1 0.660198575 0.641057787 6019 relaxin 2 "GO:0005179,GO:0005576,GO:0007186,GO:0007565,GO:0010628,GO:0045766,GO:0050790" hormone activity|extracellular region|G protein-coupled receptor signaling pathway|female pregnancy|positive regulation of gene expression|positive regulation of angiogenesis|regulation of catalytic activity "hsa04080,hsa04926" Neuroactive ligand-receptor interaction|Relaxin signaling pathway RMC1 944.8604651 884.3518002 1005.36913 1.136842973 0.185032995 0.455349597 1 21.44308506 23.96949745 29919 regulator of MON1-CCZ1 "GO:0005515,GO:0005765,GO:0006914,GO:0010506,GO:0031902,GO:0035658" protein binding|lysosomal membrane|autophagy|regulation of autophagy|late endosome membrane|Mon1-Ccz1 complex RMDN1 1536.741378 1358.780531 1714.702225 1.261942004 0.335645608 0.159185515 1 10.40993678 12.91691098 51115 regulator of microtubule dynamics 1 "GO:0005737,GO:0005876,GO:0007052,GO:0008017,GO:0051315,GO:0097431" cytoplasm|spindle microtubule|mitotic spindle organization|microtubule binding|attachment of mitotic spindle microtubules to kinetochore|mitotic spindle pole RMDN2 21.89838134 19.76786377 24.0288989 1.215553647 0.281613566 0.777119974 1 0.224797477 0.268680867 151393 regulator of microtubule dynamics 2 "GO:0005515,GO:0005794,GO:0005829,GO:0005876,GO:0008017,GO:0016021,GO:0072686,GO:0097431" protein binding|Golgi apparatus|cytosol|spindle microtubule|microtubule binding|integral component of membrane|mitotic spindle|mitotic spindle pole RMDN3 546.8946671 504.6007331 589.188601 1.167633264 0.223587217 0.405787014 1 7.972058528 9.152676571 55177 regulator of microtubule dynamics 3 "GO:0005515,GO:0005634,GO:0005739,GO:0005741,GO:0005876,GO:0006874,GO:0006915,GO:0008017,GO:0016021,GO:0030154,GO:0044232,GO:0045171,GO:0097431" protein binding|nucleus|mitochondrion|mitochondrial outer membrane|spindle microtubule|cellular calcium ion homeostasis|apoptotic process|microtubule binding|integral component of membrane|cell differentiation|organelle membrane contact site|intercellular bridge|mitotic spindle pole RMI1 498.1430552 536.8535634 459.432547 0.855787459 -0.224675557 0.41327731 1 7.840965513 6.597913845 80010 RecQ mediated genome instability 1 "GO:0000166,GO:0000712,GO:0000724,GO:0002023,GO:0005515,GO:0005654,GO:0006260,GO:0009749,GO:0016604,GO:0031422,GO:0035264,GO:0042593,GO:1901796" nucleotide binding|resolution of meiotic recombination intermediates|double-strand break repair via homologous recombination|reduction of food intake in response to dietary excess|protein binding|nucleoplasm|DNA replication|response to glucose|nuclear body|RecQ family helicase-topoisomerase III complex|multicellular organism growth|glucose homeostasis|regulation of signal transduction by p53 class mediator hsa03460 Fanconi anemia pathway RMI2 443.6301524 455.7012806 431.5590242 0.94702175 -0.078530535 0.786915237 1 17.04270484 15.86973426 116028 RecQ mediated genome instability 2 "GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0006260,GO:0006281,GO:0016607,GO:0033045,GO:0043007,GO:1901796,GO:2000042" DNA binding|protein binding|nucleoplasm|cytosol|DNA replication|DNA repair|nuclear speck|regulation of sister chromatid segregation|maintenance of rDNA|regulation of signal transduction by p53 class mediator|negative regulation of double-strand break repair via homologous recombination hsa03460 Fanconi anemia pathway RMND1 432.4925706 466.1054194 398.8797217 0.855771474 -0.224702506 0.429847432 1 12.59503269 10.5981066 55005 required for meiotic nuclear division 1 homolog "GO:0005515,GO:0005739,GO:0006412,GO:0070131" protein binding|mitochondrion|translation|positive regulation of mitochondrial translation RMND5A 579.3110437 560.7830827 597.8390046 1.066078887 0.092314197 0.732297705 1 4.84036268 5.073859358 64795 required for meiotic nuclear division 5 homolog A "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0034657,GO:0043161,GO:0046872" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|GID complex|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding RMND5B 403.2471254 392.2360338 414.258217 1.056145232 0.078808236 0.79215216 1 4.6178946 4.795554575 64777 required for meiotic nuclear division 5 homolog B "GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0016567,GO:0034657,GO:0043161,GO:0046872" ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|cytosol|protein ubiquitination|GID complex|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding RNASE4 294.3798357 234.0931236 354.6665478 1.515066066 0.599380705 0.058316049 1 5.642782187 8.406128727 6038 ribonuclease A family member 4 "GO:0003676,GO:0004522,GO:0004540,GO:0005576,GO:0005615,GO:0006379,GO:0090501,GO:0090502" "nucleic acid binding|ribonuclease A activity|ribonuclease activity|extracellular region|extracellular space|mRNA cleavage|RNA phosphodiester bond hydrolysis|RNA phosphodiester bond hydrolysis, endonucleolytic" RNASE7 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.122301711 0 84659 ribonuclease A family member 7 "GO:0001530,GO:0003676,GO:0004519,GO:0004540,GO:0005576,GO:0005615,GO:0005737,GO:0019730,GO:0019731,GO:0042834,GO:0045087,GO:0050829,GO:0050830,GO:0050832,GO:0051673,GO:0061844,GO:0090501" lipopolysaccharide binding|nucleic acid binding|endonuclease activity|ribonuclease activity|extracellular region|extracellular space|cytoplasm|antimicrobial humoral response|antibacterial humoral response|peptidoglycan binding|innate immune response|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|defense response to fungus|membrane disruption in other organism|antimicrobial humoral immune response mediated by antimicrobial peptide|RNA phosphodiester bond hydrolysis RNASEH1 1200.436787 1210.001346 1190.872229 0.984190831 -0.022990019 0.927941081 1 11.6836526 11.30652451 246243 ribonuclease H1 "GO:0000287,GO:0003676,GO:0003723,GO:0004523,GO:0004540,GO:0005515,GO:0005737,GO:0006401,GO:0043137,GO:0090502" "magnesium ion binding|nucleic acid binding|RNA binding|RNA-DNA hybrid ribonuclease activity|ribonuclease activity|protein binding|cytoplasm|RNA catabolic process|DNA replication, removal of RNA primer|RNA phosphodiester bond hydrolysis, endonucleolytic" hsa03030 DNA replication RNASEH2A 1344.987578 1068.505057 1621.470098 1.517512796 0.601708682 0.012361437 0.660322851 48.98982052 73.09865548 10535 ribonuclease H2 subunit A "GO:0003723,GO:0004523,GO:0004540,GO:0005654,GO:0005829,GO:0006260,GO:0006298,GO:0006401,GO:0032299,GO:0043137,GO:0046872,GO:0090502" "RNA binding|RNA-DNA hybrid ribonuclease activity|ribonuclease activity|nucleoplasm|cytosol|DNA replication|mismatch repair|RNA catabolic process|ribonuclease H2 complex|DNA replication, removal of RNA primer|metal ion binding|RNA phosphodiester bond hydrolysis, endonucleolytic" hsa03030 DNA replication RNASEH2B 489.3196589 469.2266611 509.4126567 1.085643036 0.118549816 0.671014355 1 5.552497672 5.927159501 79621 ribonuclease H2 subunit B "GO:0005654,GO:0006401,GO:0009259,GO:0032299" nucleoplasm|RNA catabolic process|ribonucleotide metabolic process|ribonuclease H2 complex hsa03030 DNA replication RNASEH2C 480.8082638 422.4080364 539.2084913 1.276510968 0.352205934 0.202020021 1 8.522926483 10.69755361 84153 ribonuclease H2 subunit C "GO:0005515,GO:0005634,GO:0006401,GO:0032299" protein binding|nucleus|RNA catabolic process|ribonuclease H2 complex hsa03030 DNA replication RNASEK 2357.761794 2171.343773 2544.179816 1.171707515 0.228612484 0.333632286 1 192.1735098 221.4032113 440400 ribonuclease K "GO:0004521,GO:0005515,GO:0005575,GO:0016021,GO:0090502" "endoribonuclease activity|protein binding|cellular_component|integral component of membrane|RNA phosphodiester bond hydrolysis, endonucleolytic" RNASEL 48.99883208 49.93986637 48.0577978 0.962313304 -0.055421421 0.963972732 1 0.628881284 0.595053945 6041 ribonuclease L "GO:0003723,GO:0004521,GO:0004540,GO:0004672,GO:0005515,GO:0005524,GO:0005575,GO:0005759,GO:0005829,GO:0006364,GO:0006396,GO:0006397,GO:0006468,GO:0016363,GO:0019843,GO:0043021,GO:0043488,GO:0045071,GO:0045444,GO:0045944,GO:0046326,GO:0046872,GO:0051607,GO:0060337,GO:0060338,GO:0090502" "RNA binding|endoribonuclease activity|ribonuclease activity|protein kinase activity|protein binding|ATP binding|cellular_component|mitochondrial matrix|cytosol|rRNA processing|RNA processing|mRNA processing|protein phosphorylation|nuclear matrix|rRNA binding|ribonucleoprotein complex binding|regulation of mRNA stability|negative regulation of viral genome replication|fat cell differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of glucose import|metal ion binding|defense response to virus|type I interferon signaling pathway|regulation of type I interferon-mediated signaling pathway|RNA phosphodiester bond hydrolysis, endonucleolytic" "hsa04621,hsa05160,hsa05164,hsa05168" NOD-like receptor signaling pathway|Hepatitis C|Influenza A|Herpes simplex virus 1 infection RNASET2 260.3625949 274.669265 246.0559247 0.895826203 -0.158709229 0.638009503 1 1.743617682 1.535840814 8635 ribonuclease T2 "GO:0003723,GO:0004521,GO:0004540,GO:0005576,GO:0005615,GO:0005758,GO:0005764,GO:0005788,GO:0006401,GO:0016829,GO:0033897,GO:0035578,GO:0043202,GO:0043312,GO:0045087,GO:0070062,GO:0090502" "RNA binding|endoribonuclease activity|ribonuclease activity|extracellular region|extracellular space|mitochondrial intermembrane space|lysosome|endoplasmic reticulum lumen|RNA catabolic process|lyase activity|ribonuclease T2 activity|azurophil granule lumen|lysosomal lumen|neutrophil degranulation|innate immune response|extracellular exosome|RNA phosphodiester bond hydrolysis, endonucleolytic" RND1 25.2177678 31.21241648 19.22311912 0.615880514 -0.699277611 0.3785228 1 1.007712826 0.61024528 27289 Rho family GTPase 1 "GO:0003924,GO:0005102,GO:0005515,GO:0005525,GO:0005829,GO:0005856,GO:0005886,GO:0005912,GO:0005938,GO:0007015,GO:0007162,GO:0007163,GO:0007264,GO:0008360,GO:0015629,GO:0016322,GO:0016477,GO:0019901,GO:0030865,GO:0031410,GO:0032956,GO:0042995,GO:0043231" GTPase activity|signaling receptor binding|protein binding|GTP binding|cytosol|cytoskeleton|plasma membrane|adherens junction|cell cortex|actin filament organization|negative regulation of cell adhesion|establishment or maintenance of cell polarity|small GTPase mediated signal transduction|regulation of cell shape|actin cytoskeleton|neuron remodeling|cell migration|protein kinase binding|cortical cytoskeleton organization|cytoplasmic vesicle|regulation of actin cytoskeleton organization|cell projection|intracellular membrane-bounded organelle hsa04360 Axon guidance RND3 5076.32195 4629.841778 5522.802123 1.192870597 0.254437547 0.289557013 1 91.99037468 107.8963864 390 Rho family GTPase 3 "GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005856,GO:0005886,GO:0005925,GO:0005938,GO:0007015,GO:0007155,GO:0007163,GO:0007264,GO:0008360,GO:0016477,GO:0019901,GO:0030036,GO:0030865,GO:0031410,GO:0032956,GO:0042995,GO:0043231" Golgi membrane|GTPase activity|protein binding|GTP binding|cytoskeleton|plasma membrane|focal adhesion|cell cortex|actin filament organization|cell adhesion|establishment or maintenance of cell polarity|small GTPase mediated signal transduction|regulation of cell shape|cell migration|protein kinase binding|actin cytoskeleton organization|cortical cytoskeleton organization|cytoplasmic vesicle|regulation of actin cytoskeleton organization|cell projection|intracellular membrane-bounded organelle RNF10 3022.699392 2822.642864 3222.75592 1.141751215 0.191248326 0.419450121 1 37.45381945 42.04736393 9921 ring finger protein 10 "GO:0000976,GO:0005515,GO:0005634,GO:0005737,GO:0010626,GO:0031643,GO:0045893,GO:0045944,GO:0046872,GO:0051865,GO:0061630" "transcription regulatory region sequence-specific DNA binding|protein binding|nucleus|cytoplasm|negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity" RNF103 573.023901 559.7426689 586.3051332 1.047454778 0.06688796 0.806745874 1 5.86193828 6.037368748 7844 ring finger protein 103 "GO:0004842,GO:0005515,GO:0005783,GO:0005789,GO:0007417,GO:0016021,GO:0016567,GO:0030433,GO:0044322,GO:0046872,GO:0061630,GO:1904380" ubiquitin-protein transferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|central nervous system development|integral component of membrane|protein ubiquitination|ubiquitin-dependent ERAD pathway|endoplasmic reticulum quality control compartment|metal ion binding|ubiquitin protein ligase activity|endoplasmic reticulum mannose trimming RNF11 2224.008245 2053.777004 2394.239486 1.165773831 0.221287922 0.349462547 1 35.65592194 40.8711776 26994 ring finger protein 11 "GO:0000151,GO:0003677,GO:0005515,GO:0005634,GO:0005769,GO:0006511,GO:0008270,GO:0051865,GO:0055037,GO:0061630,GO:0070062" ubiquitin ligase complex|DNA binding|protein binding|nucleus|early endosome|ubiquitin-dependent protein catabolic process|zinc ion binding|protein autoubiquitination|recycling endosome|ubiquitin protein ligase activity|extracellular exosome RNF111 705.4294508 742.8555122 668.0033894 0.899237306 -0.153226206 0.551839254 1 6.742318601 5.96148925 54778 ring finger protein 111 "GO:0000209,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0007389,GO:0016567,GO:0016605,GO:0030511,GO:0030579,GO:0031398,GO:0032184,GO:0032991,GO:0045893,GO:0045944,GO:0046332,GO:0046872,GO:0061630,GO:0070911" "protein polyubiquitination|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|pattern specification process|protein ubiquitination|PML body|positive regulation of transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process|positive regulation of protein ubiquitination|SUMO polymer binding|protein-containing complex|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|SMAD binding|metal ion binding|ubiquitin protein ligase activity|global genome nucleotide-excision repair" RNF112 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.007426104 0.026982358 7732 ring finger protein 112 "GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0007029,GO:0007050,GO:0008021,GO:0008270,GO:0014069,GO:0016021,GO:0016604,GO:0019898,GO:0030182,GO:0033194,GO:0036473,GO:0036474,GO:0043005,GO:0043204,GO:0043621,GO:0044297,GO:0045666,GO:0045687,GO:0051260,GO:0051865,GO:0061630,GO:0071158,GO:1990403" GTPase activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|endosome|endoplasmic reticulum organization|cell cycle arrest|synaptic vesicle|zinc ion binding|postsynaptic density|integral component of membrane|nuclear body|extrinsic component of membrane|neuron differentiation|response to hydroperoxide|cell death in response to oxidative stress|cell death in response to hydrogen peroxide|neuron projection|perikaryon|protein self-association|cell body|positive regulation of neuron differentiation|positive regulation of glial cell differentiation|protein homooligomerization|protein autoubiquitination|ubiquitin protein ligase activity|positive regulation of cell cycle arrest|embryonic brain development RNF113A 527.5576915 488.9945248 566.1208581 1.157724329 0.211291767 0.436064977 1 20.72814858 23.59591654 7737 ring finger protein 113A "GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005684,GO:0006281,GO:0016567,GO:0016607,GO:0018276,GO:0034247,GO:0046872,GO:0061630,GO:0070100,GO:0071005" "mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|U2-type spliceosomal complex|DNA repair|protein ubiquitination|nuclear speck|isopeptide cross-linking via N6-glycyl-L-lysine|snoRNA splicing|metal ion binding|ubiquitin protein ligase activity|negative regulation of chemokine-mediated signaling pathway|U2-type precatalytic spliceosome" RNF114 1902.844991 1797.835189 2007.854792 1.116818051 0.159394165 0.501605846 1 39.21011842 43.05779218 55905 ring finger protein 114 "GO:0000209,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0006511,GO:0007275,GO:0007283,GO:0030154,GO:0046872,GO:0061630" protein polyubiquitination|protein binding|nucleus|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|multicellular organism development|spermatogenesis|cell differentiation|metal ion binding|ubiquitin protein ligase activity RNF115 864.8266253 928.0491833 801.6040673 0.863751708 -0.211311436 0.397767374 1 5.411152544 4.595680995 27246 ring finger protein 115 "GO:0000209,GO:0004842,GO:0005515,GO:0005829,GO:0042059,GO:0043162,GO:0046872,GO:0051865,GO:0061630,GO:0070534,GO:0070936" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytosol|negative regulation of epidermal growth factor receptor signaling pathway|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination RNF121 505.4907334 490.0349387 520.9465281 1.063080379 0.088250682 0.751915147 1 8.940944969 9.34589081 55298 ring finger protein 121 "GO:0000139,GO:0005789,GO:0016021,GO:0016567,GO:0030433,GO:0030968,GO:0046872,GO:0061630" Golgi membrane|endoplasmic reticulum membrane|integral component of membrane|protein ubiquitination|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|metal ion binding|ubiquitin protein ligase activity RNF122 81.74230126 89.47559391 74.00900861 0.827141854 -0.273793324 0.598581058 1 2.172496814 1.766893299 79845 ring finger protein 122 "GO:0005515,GO:0005737,GO:0005783,GO:0005794,GO:0010917,GO:0012505,GO:0016021,GO:0043065,GO:0043161,GO:0046872,GO:0051865,GO:0061630" protein binding|cytoplasm|endoplasmic reticulum|Golgi apparatus|negative regulation of mitochondrial membrane potential|endomembrane system|integral component of membrane|positive regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity RNF123 820.5844976 801.1186896 840.0503055 1.048596564 0.068459724 0.789020344 1 9.788056793 10.09197322 63891 ring finger protein 123 "GO:0004842,GO:0005737,GO:0005829,GO:0016567,GO:0016579,GO:0031965,GO:0046872,GO:0051603" ubiquitin-protein transferase activity|cytoplasm|cytosol|protein ubiquitination|protein deubiquitination|nuclear membrane|metal ion binding|proteolysis involved in cellular protein catabolic process RNF125 170.8863866 196.6382238 145.1345494 0.738079029 -0.438152795 0.257469607 1 1.626002572 1.180036044 54941 ring finger protein 125 "GO:0000139,GO:0000209,GO:0002039,GO:0002250,GO:0005515,GO:0006511,GO:0008270,GO:0031624,GO:0032480,GO:0034098,GO:0039536,GO:0043231,GO:0061630,GO:1990830" Golgi membrane|protein polyubiquitination|p53 binding|adaptive immune response|protein binding|ubiquitin-dependent protein catabolic process|zinc ion binding|ubiquitin conjugating enzyme binding|negative regulation of type I interferon production|VCP-NPL4-UFD1 AAA ATPase complex|negative regulation of RIG-I signaling pathway|intracellular membrane-bounded organelle|ubiquitin protein ligase activity|cellular response to leukemia inhibitory factor hsa04622 RIG-I-like receptor signaling pathway RNF126 679.6424007 633.6120545 725.6727468 1.145295045 0.195719306 0.448798121 1 20.73250204 23.34749426 55658 ring finger protein 126 "GO:0005154,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0006513,GO:0042059,GO:0042127,GO:0042147,GO:0043161,GO:0043162,GO:0046872,GO:0061630,GO:0070534,GO:0070936,GO:0071629" "epidermal growth factor receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein monoubiquitination|negative regulation of epidermal growth factor receptor signaling pathway|regulation of cell population proliferation|retrograde transport, endosome to Golgi|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|metal ion binding|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|cytoplasm protein quality control by the ubiquitin-proteasome system" RNF128 128.2394782 86.35435226 170.1246042 1.970075622 0.978251009 0.023178336 0.842988688 1.365907845 2.64591248 79589 ring finger protein 128 "GO:0001818,GO:0005515,GO:0005737,GO:0005770,GO:0005783,GO:0005794,GO:0005829,GO:0005856,GO:0006511,GO:0016021,GO:0016567,GO:0016579,GO:0031647,GO:0046872,GO:0048471,GO:0061462,GO:0061630,GO:1904352" negative regulation of cytokine production|protein binding|cytoplasm|late endosome|endoplasmic reticulum|Golgi apparatus|cytosol|cytoskeleton|ubiquitin-dependent protein catabolic process|integral component of membrane|protein ubiquitination|protein deubiquitination|regulation of protein stability|metal ion binding|perinuclear region of cytoplasm|protein localization to lysosome|ubiquitin protein ligase activity|positive regulation of protein catabolic process in the vacuole RNF13 952.7717809 1028.96933 876.5742319 0.851895393 -0.231251807 0.349611265 1 14.55837804 12.19468091 11342 ring finger protein 13 "GO:0000139,GO:0004842,GO:0005515,GO:0005637,GO:0005654,GO:0005765,GO:0005783,GO:0005789,GO:0005829,GO:0006511,GO:0008432,GO:0016021,GO:0031902,GO:0043231,GO:0046872,GO:0051865,GO:0061630,GO:0070304" Golgi membrane|ubiquitin-protein transferase activity|protein binding|nuclear inner membrane|nucleoplasm|lysosomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|ubiquitin-dependent protein catabolic process|JUN kinase binding|integral component of membrane|late endosome membrane|intracellular membrane-bounded organelle|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|positive regulation of stress-activated protein kinase signaling cascade RNF130 959.0148786 940.5341499 977.4956072 1.039298368 0.055609892 0.825489606 1 3.694309189 3.775240855 55819 ring finger protein 130 "GO:0004842,GO:0005737,GO:0006511,GO:0006915,GO:0012501,GO:0016021,GO:0016567,GO:0046872,GO:0061630" ubiquitin-protein transferase activity|cytoplasm|ubiquitin-dependent protein catabolic process|apoptotic process|programmed cell death|integral component of membrane|protein ubiquitination|metal ion binding|ubiquitin protein ligase activity RNF135 430.6249789 429.6909335 431.5590242 1.004347522 0.006258553 0.99177073 1 7.347585833 7.256043188 84282 ring finger protein 135 "GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0010494,GO:0010994,GO:0016567,GO:0032480,GO:0032728,GO:0039529,GO:0039552,GO:0042802,GO:0043021,GO:0045087,GO:0045088,GO:0046872,GO:0051260,GO:0061630,GO:0070534,GO:0140374,GO:1990904" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|cytoplasmic stress granule|free ubiquitin chain polymerization|protein ubiquitination|negative regulation of type I interferon production|positive regulation of interferon-beta production|RIG-I signaling pathway|RIG-I binding|identical protein binding|ribonucleoprotein complex binding|innate immune response|regulation of innate immune response|metal ion binding|protein homooligomerization|ubiquitin protein ligase activity|protein K63-linked ubiquitination|antiviral innate immune response|ribonucleoprotein complex RNF138 739.8228596 762.623376 717.0223432 0.940205042 -0.088952678 0.730309215 1 11.37183792 10.51294557 51444 ring finger protein 138 "GO:0000724,GO:0003697,GO:0005515,GO:0005634,GO:0010792,GO:0016055,GO:0016567,GO:0019901,GO:0035861,GO:0046872,GO:0061630,GO:1990830" double-strand break repair via homologous recombination|single-stranded DNA binding|protein binding|nucleus|DNA double-strand break processing involved in repair via single-strand annealing|Wnt signaling pathway|protein ubiquitination|protein kinase binding|site of double-strand break|metal ion binding|ubiquitin protein ligase activity|cellular response to leukemia inhibitory factor RNF139 876.7177718 836.4927616 916.942782 1.096175393 0.132478655 0.597144263 1 13.95501134 15.04116312 11236 ring finger protein 139 "GO:0002020,GO:0004842,GO:0005515,GO:0005783,GO:0005789,GO:0008270,GO:0008285,GO:0012505,GO:0016021,GO:0016567,GO:0017148,GO:0018215,GO:0019787,GO:0031648,GO:0036503,GO:0036513,GO:0038023,GO:0044322,GO:0060628,GO:0061630,GO:0070613,GO:1904380,GO:2000060" protease binding|ubiquitin-protein transferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|zinc ion binding|negative regulation of cell population proliferation|endomembrane system|integral component of membrane|protein ubiquitination|negative regulation of translation|protein phosphopantetheinylation|ubiquitin-like protein transferase activity|protein destabilization|ERAD pathway|Derlin-1 retrotranslocation complex|signaling receptor activity|endoplasmic reticulum quality control compartment|regulation of ER to Golgi vesicle-mediated transport|ubiquitin protein ligase activity|regulation of protein processing|endoplasmic reticulum mannose trimming|positive regulation of ubiquitin-dependent protein catabolic process RNF14 1383.704345 1391.033361 1376.375329 0.989462487 -0.015283083 0.952413312 1 18.8657926 18.3546272 9604 ring finger protein 14 "GO:0000151,GO:0000209,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0006511,GO:0007165,GO:0016567,GO:0018215,GO:0019787,GO:0030521,GO:0031624,GO:0032436,GO:0045893,GO:0046872,GO:0050681,GO:0060765,GO:0061630" "ubiquitin ligase complex|protein polyubiquitination|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|ubiquitin-dependent protein catabolic process|signal transduction|protein ubiquitination|protein phosphopantetheinylation|ubiquitin-like protein transferase activity|androgen receptor signaling pathway|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-templated|metal ion binding|androgen receptor binding|regulation of androgen receptor signaling pathway|ubiquitin protein ligase activity" RNF141 527.007302 562.8639105 491.1506935 0.872592263 -0.196620413 0.468914111 1 7.41887192 6.365322469 50862 ring finger protein 141 "GO:0004842,GO:0005515,GO:0006355,GO:0016020,GO:0046872,GO:0051865" "ubiquitin-protein transferase activity|protein binding|regulation of transcription, DNA-templated|membrane|metal ion binding|protein autoubiquitination" RNF144A 37.66813585 42.65696919 32.6793025 0.766095274 -0.384404273 0.583525258 1 0.100459999 0.075674077 9781 ring finger protein 144A "GO:0000151,GO:0000209,GO:0005515,GO:0005737,GO:0005794,GO:0005886,GO:0006511,GO:0010008,GO:0016021,GO:0016567,GO:0030659,GO:0031624,GO:0032436,GO:0043231,GO:0046872,GO:0061630" ubiquitin ligase complex|protein polyubiquitination|protein binding|cytoplasm|Golgi apparatus|plasma membrane|ubiquitin-dependent protein catabolic process|endosome membrane|integral component of membrane|protein ubiquitination|cytoplasmic vesicle membrane|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|metal ion binding|ubiquitin protein ligase activity RNF144B 126.0988998 131.0921492 121.1056505 0.923820772 -0.11431511 0.80703373 1 1.38455315 1.257675305 255488 ring finger protein 144B "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0006511,GO:0006915,GO:0016021,GO:0031624,GO:0031966,GO:0032436,GO:0043066,GO:0046872,GO:0061630" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|apoptotic process|integral component of membrane|ubiquitin conjugating enzyme binding|mitochondrial membrane|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of apoptotic process|metal ion binding|ubiquitin protein ligase activity RNF145 2480.703625 2484.508352 2476.898899 0.99693724 -0.004425409 0.986987871 1 27.64671485 27.10082618 153830 ring finger protein 145 "GO:0005783,GO:0005789,GO:0008270,GO:0012505,GO:0016021,GO:0016567,GO:0061630" endoplasmic reticulum|endoplasmic reticulum membrane|zinc ion binding|endomembrane system|integral component of membrane|protein ubiquitination|ubiquitin protein ligase activity RNF146 385.5600894 356.8619617 414.258217 1.160836013 0.215164183 0.464584274 1 2.179568209 2.487783118 81847 ring finger protein 146 "GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006511,GO:0008270,GO:0016055,GO:0051865,GO:0061630,GO:0070936,GO:0072572,GO:0090263" ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|zinc ion binding|Wnt signaling pathway|protein autoubiquitination|ubiquitin protein ligase activity|protein K48-linked ubiquitination|poly-ADP-D-ribose binding|positive regulation of canonical Wnt signaling pathway RNF149 1235.276176 1216.243829 1254.308523 1.031296927 0.044459767 0.857122241 1 7.131256623 7.231376393 284996 ring finger protein 149 "GO:0005737,GO:0006511,GO:0016020,GO:0016021,GO:0016567,GO:0031647,GO:0035690,GO:0043409,GO:0046872,GO:0061630" cytoplasm|ubiquitin-dependent protein catabolic process|membrane|integral component of membrane|protein ubiquitination|regulation of protein stability|cellular response to drug|negative regulation of MAPK cascade|metal ion binding|ubiquitin protein ligase activity RNF150 92.50813117 107.1626299 77.85363244 0.72649983 -0.460965634 0.341337857 1 0.5378101 0.384180794 57484 ring finger protein 150 "GO:0005737,GO:0006511,GO:0016021,GO:0016567,GO:0046872,GO:0061630" cytoplasm|ubiquitin-dependent protein catabolic process|integral component of membrane|protein ubiquitination|metal ion binding|ubiquitin protein ligase activity RNF152 105.4837366 107.1626299 103.8048432 0.96866644 -0.045928135 0.942421363 1 0.602324655 0.573688406 220441 ring finger protein 152 "GO:0004842,GO:0005515,GO:0005764,GO:0005765,GO:0006915,GO:0010508,GO:0016567,GO:0031267,GO:0031301,GO:0034198,GO:0046872,GO:0061630,GO:0070534,GO:0070936,GO:1904262" ubiquitin-protein transferase activity|protein binding|lysosome|lysosomal membrane|apoptotic process|positive regulation of autophagy|protein ubiquitination|small GTPase binding|integral component of organelle membrane|cellular response to amino acid starvation|metal ion binding|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|negative regulation of TORC1 signaling hsa04150 mTOR signaling pathway RNF157 63.69357417 57.22276355 70.16438479 1.226162115 0.294149735 0.60826206 1 0.345969607 0.417116164 114804 ring finger protein 157 "GO:0005634,GO:0005737,GO:0005769,GO:0005886,GO:0008333,GO:0016567,GO:0043066,GO:0043951,GO:0044297,GO:0045744,GO:0046872,GO:0051865,GO:0061630,GO:1903861" nucleus|cytoplasm|early endosome|plasma membrane|endosome to lysosome transport|protein ubiquitination|negative regulation of apoptotic process|negative regulation of cAMP-mediated signaling|cell body|negative regulation of G protein-coupled receptor signaling pathway|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|positive regulation of dendrite extension RNF166 413.7600903 441.1354862 386.3846943 0.875886675 -0.191183873 0.50800549 1 7.293243534 6.281159383 115992 ring finger protein 166 "GO:0000209,GO:0005515,GO:0005737,GO:0006511,GO:0006914,GO:0045087,GO:0046872,GO:0061630" protein polyubiquitination|protein binding|cytoplasm|ubiquitin-dependent protein catabolic process|autophagy|innate immune response|metal ion binding|ubiquitin protein ligase activity RNF167 1524.007963 1453.458194 1594.557731 1.097078497 0.133666756 0.576382063 1 33.3771052 36.0045634 26001 ring finger protein 167 "GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0006511,GO:0008270,GO:0012505,GO:0016021,GO:0045786,GO:0061630" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|ubiquitin-dependent protein catabolic process|zinc ion binding|endomembrane system|integral component of membrane|negative regulation of cell cycle|ubiquitin protein ligase activity RNF168 754.4188364 716.8451651 791.9925077 1.104830647 0.143825245 0.573109253 1 7.154798758 7.772564134 165918 ring finger protein 168 "GO:0000151,GO:0003682,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006302,GO:0006303,GO:0006511,GO:0006974,GO:0010212,GO:0016567,GO:0031491,GO:0032991,GO:0034244,GO:0035518,GO:0035861,GO:0036297,GO:0036351,GO:0036352,GO:0042393,GO:0043130,GO:0045190,GO:0045739,GO:0046872,GO:0070530,GO:0070534,GO:0070535" ubiquitin ligase complex|chromatin binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytosol|double-strand break repair|double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|response to ionizing radiation|protein ubiquitination|nucleosome binding|protein-containing complex|negative regulation of transcription elongation from RNA polymerase II promoter|histone H2A monoubiquitination|site of double-strand break|interstrand cross-link repair|histone H2A-K13 ubiquitination|histone H2A-K15 ubiquitination|histone binding|ubiquitin binding|isotype switching|positive regulation of DNA repair|metal ion binding|K63-linked polyubiquitin modification-dependent protein binding|protein K63-linked ubiquitination|histone H2A K63-linked ubiquitination RNF169 1229.152579 1206.880104 1251.425055 1.036909177 0.052289533 0.831717474 1 8.147877671 8.307233095 254225 ring finger protein 169 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006974,GO:0016567,GO:0016604,GO:0016740,GO:0031491,GO:0035861,GO:0046872,GO:0070530,GO:2000780" protein binding|nucleus|nucleoplasm|nucleolus|cytosol|cellular response to DNA damage stimulus|protein ubiquitination|nuclear body|transferase activity|nucleosome binding|site of double-strand break|metal ion binding|K63-linked polyubiquitin modification-dependent protein binding|negative regulation of double-strand break repair RNF17 6.004709516 6.242483296 5.766935736 0.923820772 -0.11431511 1 1 0.039360806 0.035753856 56163 ring finger protein 17 "GO:0005634,GO:0005737,GO:0007275,GO:0007283,GO:0030154,GO:0046872" nucleus|cytoplasm|multicellular organism development|spermatogenesis|cell differentiation|metal ion binding RNF170 182.6284637 176.87036 188.3865674 1.065111007 0.091003798 0.822072349 1 1.708770102 1.78957411 81790 ring finger protein 170 "GO:0005515,GO:0005789,GO:0016021,GO:0016567,GO:0046872,GO:0061630" protein binding|endoplasmic reticulum membrane|integral component of membrane|protein ubiquitination|metal ion binding|ubiquitin protein ligase activity RNF180 50.63871083 55.14193578 46.13548589 0.836667869 -0.257273064 0.688430132 1 0.254966537 0.209752649 285671 ring finger protein 180 "GO:0000209,GO:0005635,GO:0016021,GO:0030534,GO:0031227,GO:0031398,GO:0031624,GO:0032436,GO:0042415,GO:0042428,GO:0046872,GO:0050790,GO:0061630" protein polyubiquitination|nuclear envelope|integral component of membrane|adult behavior|intrinsic component of endoplasmic reticulum membrane|positive regulation of protein ubiquitination|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|norepinephrine metabolic process|serotonin metabolic process|metal ion binding|regulation of catalytic activity|ubiquitin protein ligase activity RNF181 1388.828385 1197.516379 1580.140392 1.319514638 0.400007356 0.09514349 1 23.17231624 30.06455901 51255 ring finger protein 181 "GO:0004842,GO:0005515,GO:0005737,GO:0016567,GO:0046872,GO:0051865,GO:0061630" ubiquitin-protein transferase activity|protein binding|cytoplasm|protein ubiquitination|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity RNF182 100.331357 72.82897178 127.8337421 1.755259466 0.811684309 0.082994085 1 0.947756247 1.635720733 221687 ring finger protein 182 "GO:0004842,GO:0005515,GO:0005737,GO:0016021,GO:0016567,GO:0046872" ubiquitin-protein transferase activity|protein binding|cytoplasm|integral component of membrane|protein ubiquitination|metal ion binding RNF185 1684.738045 1610.56069 1758.915399 1.092113703 0.127123067 0.59372697 1 27.01215084 29.00669184 91445 ring finger protein 185 "GO:0005515,GO:0005741,GO:0005783,GO:0005789,GO:0006511,GO:0006914,GO:0016021,GO:0030433,GO:0036503,GO:0043130,GO:0044322,GO:0044390,GO:0044877,GO:0046872,GO:0051865,GO:0055085,GO:0061630,GO:0071712,GO:1904294,GO:1904380" protein binding|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|ubiquitin-dependent protein catabolic process|autophagy|integral component of membrane|ubiquitin-dependent ERAD pathway|ERAD pathway|ubiquitin binding|endoplasmic reticulum quality control compartment|ubiquitin-like protein conjugating enzyme binding|protein-containing complex binding|metal ion binding|protein autoubiquitination|transmembrane transport|ubiquitin protein ligase activity|ER-associated misfolded protein catabolic process|positive regulation of ERAD pathway|endoplasmic reticulum mannose trimming hsa04141 Protein processing in endoplasmic reticulum RNF187 2406.719154 2523.003665 2290.434643 0.907820577 -0.139520906 0.55563661 1 43.18411435 38.54741133 149603 ring finger protein 187 "GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008284,GO:0010468,GO:0016567,GO:0043161,GO:0045087,GO:0045893,GO:0046872,GO:0051865,GO:0061630,GO:0070936" "ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|positive regulation of cell population proliferation|regulation of gene expression|protein ubiquitination|proteasome-mediated ubiquitin-dependent protein catabolic process|innate immune response|positive regulation of transcription, DNA-templated|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|protein K48-linked ubiquitination" RNF19A 1543.686508 1515.883027 1571.489988 1.036682884 0.051974648 0.829768445 1 16.95659004 17.28445249 25897 "ring finger protein 19A, RBR E3 ubiquitin protein ligase" "GO:0000151,GO:0000209,GO:0000226,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0006511,GO:0008134,GO:0016021,GO:0031624,GO:0032436,GO:0046872,GO:0061630,GO:0098686,GO:0098794,GO:0098978,GO:0099576" "ubiquitin ligase complex|protein polyubiquitination|microtubule cytoskeleton organization|protein binding|cytoplasm|centrosome|cytosol|ubiquitin-dependent protein catabolic process|transcription factor binding|integral component of membrane|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity|hippocampal mossy fiber to CA3 synapse|postsynapse|glutamatergic synapse|regulation of protein catabolic process at postsynapse, modulating synaptic transmission" RNF19B 548.0885664 523.328183 572.8489498 1.0946266 0.130438821 0.630285516 1 6.187209413 6.65935231 127544 ring finger protein 19B "GO:0000151,GO:0000209,GO:0002250,GO:0005515,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0006511,GO:0016021,GO:0031624,GO:0032436,GO:0042267,GO:0043130,GO:0044194,GO:0046872,GO:0051865,GO:0061630" ubiquitin ligase complex|protein polyubiquitination|adaptive immune response|protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|ubiquitin-dependent protein catabolic process|integral component of membrane|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|natural killer cell mediated cytotoxicity|ubiquitin binding|cytolytic granule|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity RNF2 651.3725883 623.2079157 679.5372609 1.09038612 0.124839102 0.633553046 1 9.292948045 9.963341173 6045 ring finger protein 2 "GO:0000122,GO:0000151,GO:0000278,GO:0000791,GO:0001702,GO:0001739,GO:0003682,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0007281,GO:0008270,GO:0009948,GO:0010467,GO:0016604,GO:0031519,GO:0035102,GO:0035518,GO:0036353,GO:0043433,GO:0061630,GO:0070317,GO:0071339,GO:0071535" negative regulation of transcription by RNA polymerase II|ubiquitin ligase complex|mitotic cell cycle|euchromatin|gastrulation with mouth forming second|sex chromatin|chromatin binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|germ cell development|zinc ion binding|anterior/posterior axis specification|gene expression|nuclear body|PcG protein complex|PRC1 complex|histone H2A monoubiquitination|histone H2A-K119 monoubiquitination|negative regulation of DNA-binding transcription factor activity|ubiquitin protein ligase activity|negative regulation of G0 to G1 transition|MLL1 complex|RING-like zinc finger domain binding other RNF20 1762.625047 1825.926364 1699.32373 0.930663889 -0.103667866 0.663477956 1 22.76251673 20.82976256 56254 ring finger protein 20 "GO:0000151,GO:0000209,GO:0002039,GO:0003682,GO:0003713,GO:0003730,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006355,GO:0006511,GO:0007346,GO:0010390,GO:0016567,GO:0030336,GO:0031062,GO:0031625,GO:0033503,GO:0033523,GO:0042393,GO:0042802,GO:0045893,GO:0046872,GO:1900364,GO:2001168" "ubiquitin ligase complex|protein polyubiquitination|p53 binding|chromatin binding|transcription coactivator activity|mRNA 3'-UTR binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription, DNA-templated|ubiquitin-dependent protein catabolic process|regulation of mitotic cell cycle|histone monoubiquitination|protein ubiquitination|negative regulation of cell migration|positive regulation of histone methylation|ubiquitin protein ligase binding|HULC complex|histone H2B ubiquitination|histone binding|identical protein binding|positive regulation of transcription, DNA-templated|metal ion binding|negative regulation of mRNA polyadenylation|positive regulation of histone H2B ubiquitination" RNF207 378.2369489 442.1759001 314.2979976 0.71079857 -0.492487315 0.093322808 1 5.679450085 3.969392193 388591 ring finger protein 207 "GO:0005515,GO:0008270,GO:0010628,GO:0030544,GO:0044325,GO:0048471,GO:0051087,GO:0055117,GO:0086019,GO:1901207,GO:1902261,GO:1903762,GO:1903954" protein binding|zinc ion binding|positive regulation of gene expression|Hsp70 protein binding|ion channel binding|perinuclear region of cytoplasm|chaperone binding|regulation of cardiac muscle contraction|cell-cell signaling involved in cardiac conduction|regulation of heart looping|positive regulation of delayed rectifier potassium channel activity|positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization RNF208 41.9090493 53.06110801 30.75699059 0.579652249 -0.786740452 0.220743172 1 0.952176803 0.5426956 727800 ring finger protein 208 "GO:0004842,GO:0005515,GO:0005654,GO:0005829,GO:0046872,GO:0051865" ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytosol|metal ion binding|protein autoubiquitination RNF213 7216.746914 7883.215989 6550.27784 0.83091442 -0.267228201 0.275283267 1 20.98422608 17.14432658 57674 ring finger protein 213 "GO:0000209,GO:0001525,GO:0002040,GO:0004842,GO:0005730,GO:0005737,GO:0005829,GO:0006511,GO:0016020,GO:0016567,GO:0016887,GO:0046872,GO:0051260,GO:0051865,GO:2000051" protein polyubiquitination|angiogenesis|sprouting angiogenesis|ubiquitin-protein transferase activity|nucleolus|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|membrane|protein ubiquitination|ATPase activity|metal ion binding|protein homooligomerization|protein autoubiquitination|negative regulation of non-canonical Wnt signaling pathway RNF214 474.3770822 480.6712138 468.0829506 0.973811073 -0.038286189 0.897648137 1 8.405157026 8.048069509 257160 ring finger protein 214 "GO:0004842,GO:0016567,GO:0046872" ubiquitin-protein transferase activity|protein ubiquitination|metal ion binding RNF215 423.1043079 408.8826559 437.32596 1.069563489 0.097022123 0.73987082 1 10.85097755 11.4116019 200312 ring finger protein 215 "GO:0005768,GO:0005802,GO:0006511,GO:0006623,GO:0006896,GO:0016020,GO:0016021,GO:0016567,GO:0017119,GO:0046872,GO:0061630" endosome|trans-Golgi network|ubiquitin-dependent protein catabolic process|protein targeting to vacuole|Golgi to vacuole transport|membrane|integral component of membrane|protein ubiquitination|Golgi transport complex|metal ion binding|ubiquitin protein ligase activity RNF216 1497.485626 1678.187593 1316.78366 0.784646285 -0.349885655 0.142601311 1 14.1042185 10.88163435 54476 ring finger protein 216 "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006915,GO:0016032,GO:0032480,GO:0032648,GO:0043161,GO:0046872,GO:0050691,GO:0061630,GO:0070936,GO:0098685,GO:0098843,GO:0098978,GO:0099546" "protein binding|nucleus|nucleoplasm|cytosol|apoptotic process|viral process|negative regulation of type I interferon production|regulation of interferon-beta production|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|regulation of defense response to virus by host|ubiquitin protein ligase activity|protein K48-linked ubiquitination|Schaffer collateral - CA1 synapse|postsynaptic endocytic zone|glutamatergic synapse|protein catabolic process, modulating synaptic transmission" RNF217 621.6163826 624.2483296 618.9844357 0.991567628 -0.012216922 0.969537337 1 2.338878547 2.280348315 154214 ring finger protein 217 "GO:0000151,GO:0000209,GO:0004842,GO:0005737,GO:0005829,GO:0006511,GO:0016021,GO:0031624,GO:0032436,GO:0046872,GO:0061630" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|integral component of membrane|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity RNF220 1476.068437 1557.499582 1394.637292 0.895433494 -0.159341812 0.505595004 1 17.92557476 15.7825656 55182 ring finger protein 220 "GO:0004842,GO:0005515,GO:0005737,GO:0016567,GO:0046872,GO:0051865,GO:0061630,GO:0090263" ubiquitin-protein transferase activity|protein binding|cytoplasm|protein ubiquitination|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|positive regulation of canonical Wnt signaling pathway RNF227 46.47202489 59.30359131 33.64045846 0.567258369 -0.817922107 0.185090937 1 1.110499534 0.619398959 284023 ring finger protein 227 GO:0046872 metal ion binding RNF24 921.3423267 809.4420007 1033.242653 1.27648757 0.35217949 0.155230098 1 5.288740437 6.638042396 11237 ring finger protein 24 "GO:0000139,GO:0005515,GO:0005794,GO:0008270,GO:0012505,GO:0016021,GO:0016567,GO:0061630" Golgi membrane|protein binding|Golgi apparatus|zinc ion binding|endomembrane system|integral component of membrane|protein ubiquitination|ubiquitin protein ligase activity RNF25 538.6304922 539.9748051 537.2861794 0.995020831 -0.007201365 0.986453118 1 18.40195589 18.00393087 64320 ring finger protein 25 "GO:0004842,GO:0005515,GO:0005634,GO:0005829,GO:0016567,GO:0046872,GO:0051059,GO:0051092,GO:0061630" ubiquitin-protein transferase activity|protein binding|nucleus|cytosol|protein ubiquitination|metal ion binding|NF-kappaB binding|positive regulation of NF-kappaB transcription factor activity|ubiquitin protein ligase activity RNF26 1688.53175 1836.330503 1540.732997 0.839028157 -0.253208868 0.286519445 1 35.2143672 29.05143589 79102 ring finger protein 26 "GO:0005515,GO:0005789,GO:0007032,GO:0008270,GO:0016021,GO:0016567,GO:0032479,GO:0050687,GO:0061630,GO:0070979,GO:1905719" protein binding|endoplasmic reticulum membrane|endosome organization|zinc ion binding|integral component of membrane|protein ubiquitination|regulation of type I interferon production|negative regulation of defense response to virus|ubiquitin protein ligase activity|protein K11-linked ubiquitination|protein localization to perinuclear region of cytoplasm RNF31 806.88551 807.3611729 806.4098471 0.998821685 -0.001700952 1 1 12.18879263 11.97070778 55072 ring finger protein 31 "GO:0000209,GO:0004842,GO:0005515,GO:0005829,GO:0007249,GO:0009898,GO:0010803,GO:0023035,GO:0031625,GO:0035631,GO:0042802,GO:0043123,GO:0043130,GO:0046872,GO:0050852,GO:0051092,GO:0071797,GO:0097039,GO:1903955" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytosol|I-kappaB kinase/NF-kappaB signaling|cytoplasmic side of plasma membrane|regulation of tumor necrosis factor-mediated signaling pathway|CD40 signaling pathway|ubiquitin protein ligase binding|CD40 receptor complex|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|metal ion binding|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|LUBAC complex|protein linear polyubiquitination|positive regulation of protein targeting to mitochondrion "hsa04217,hsa04621,hsa05131" Necroptosis|NOD-like receptor signaling pathway|Shigellosis RNF32 12.45036805 11.44455271 13.45618338 1.175771891 0.233608194 0.899941244 1 0.145804427 0.168564052 140545 ring finger protein 32 "GO:0005515,GO:0005768,GO:0005829,GO:0016235,GO:0016604,GO:0046872" protein binding|endosome|cytosol|aggresome|nuclear body|metal ion binding RNF34 829.1902418 812.5632423 845.8172413 1.040924813 0.057865865 0.821652158 1 18.0989177 18.52435713 80196 ring finger protein 34 "GO:0002039,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006511,GO:0006915,GO:0012505,GO:0016567,GO:0016604,GO:0016607,GO:0031625,GO:0035872,GO:0043161,GO:0046872,GO:0061630,GO:0070936,GO:1901797,GO:1901981,GO:1902042,GO:2000374,GO:2001271" "p53 binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|apoptotic process|endomembrane system|protein ubiquitination|nuclear body|nuclear speck|ubiquitin protein ligase binding|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity|protein K48-linked ubiquitination|negative regulation of signal transduction by p53 class mediator|phosphatidylinositol phosphate binding|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of oxygen metabolic process|negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis" RNF38 669.6138154 774.0679287 565.1597021 0.730116416 -0.453801576 0.078402183 1 6.316602856 4.534682286 152006 ring finger protein 38 "GO:0005515,GO:0005634,GO:0005654,GO:0008584,GO:0016567,GO:0036126,GO:0046872,GO:0061630" protein binding|nucleus|nucleoplasm|male gonad development|protein ubiquitination|sperm flagellum|metal ion binding|ubiquitin protein ligase activity RNF4 2625.054427 2640.570434 2609.538421 0.988247989 -0.017054981 0.944193767 1 38.77886376 37.68184837 6047 ring finger protein 4 "GO:0003677,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008134,GO:0008270,GO:0016604,GO:0016605,GO:0030374,GO:0031491,GO:0032184,GO:0042802,GO:0043161,GO:0045893,GO:0045944,GO:0046685,GO:0051865,GO:0070534,GO:0070936,GO:0070979,GO:0085020,GO:0090169,GO:0090234,GO:1990752" "DNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|transcription factor binding|zinc ion binding|nuclear body|PML body|nuclear receptor coactivator activity|nucleosome binding|SUMO polymer binding|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|response to arsenic-containing substance|protein autoubiquitination|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination|protein K6-linked ubiquitination|regulation of spindle assembly|regulation of kinetochore assembly|microtubule end" RNF40 1785.127924 1836.330503 1733.925345 0.944233809 -0.082783955 0.728647728 1 15.85529589 14.72058524 9810 ring finger protein 40 "GO:0000151,GO:0003730,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0007346,GO:0010390,GO:0016020,GO:0016567,GO:0017075,GO:0019898,GO:0031624,GO:0031625,GO:0033503,GO:0033523,GO:0042803,GO:0043005,GO:0043434,GO:0043679,GO:0044877,GO:0046872,GO:1900364,GO:1901800,GO:1902916,GO:2001168" ubiquitin ligase complex|mRNA 3'-UTR binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|regulation of mitotic cell cycle|histone monoubiquitination|membrane|protein ubiquitination|syntaxin-1 binding|extrinsic component of membrane|ubiquitin conjugating enzyme binding|ubiquitin protein ligase binding|HULC complex|histone H2B ubiquitination|protein homodimerization activity|neuron projection|response to peptide hormone|axon terminus|protein-containing complex binding|metal ion binding|negative regulation of mRNA polyadenylation|positive regulation of proteasomal protein catabolic process|positive regulation of protein polyubiquitination|positive regulation of histone H2B ubiquitination RNF41 1481.221431 1490.913094 1471.529769 0.986999024 -0.018879437 0.9399764 1 13.77073237 13.36426073 10193 ring finger protein 41 "GO:0000209,GO:0004842,GO:0005128,GO:0005135,GO:0005515,GO:0005829,GO:0006914,GO:0008270,GO:0008285,GO:0010498,GO:0016567,GO:0019904,GO:0030336,GO:0030971,GO:0031267,GO:0042802,GO:0043408,GO:0045619,GO:0045637,GO:0045732,GO:0048471,GO:0051091,GO:0051865,GO:0051896,GO:0061630,GO:0071782,GO:0097191,GO:1901525,GO:2000114,GO:2000377,GO:2000379" protein polyubiquitination|ubiquitin-protein transferase activity|erythropoietin receptor binding|interleukin-3 receptor binding|protein binding|cytosol|autophagy|zinc ion binding|negative regulation of cell population proliferation|proteasomal protein catabolic process|protein ubiquitination|protein domain specific binding|negative regulation of cell migration|receptor tyrosine kinase binding|small GTPase binding|identical protein binding|regulation of MAPK cascade|regulation of lymphocyte differentiation|regulation of myeloid cell differentiation|positive regulation of protein catabolic process|perinuclear region of cytoplasm|positive regulation of DNA-binding transcription factor activity|protein autoubiquitination|regulation of protein kinase B signaling|ubiquitin protein ligase activity|endoplasmic reticulum tubular network|extrinsic apoptotic signaling pathway|negative regulation of mitophagy|regulation of establishment of cell polarity|regulation of reactive oxygen species metabolic process|positive regulation of reactive oxygen species metabolic process hsa04144 Endocytosis RNF44 685.661587 703.3197847 668.0033894 0.949786148 -0.074325379 0.777080563 1 6.82824891 6.376852245 22838 ring finger protein 44 "GO:0005515,GO:0046872" protein binding|metal ion binding RNF5 672.5029281 660.6628155 684.3430407 1.035843133 0.050805539 0.849188981 1 31.56522848 32.14949142 6048 ring finger protein 5 "GO:0004842,GO:0005515,GO:0005783,GO:0005789,GO:0006511,GO:0008270,GO:0009617,GO:0010507,GO:0016021,GO:0030433,GO:0031648,GO:0031966,GO:0036503,GO:0042802,GO:0044257,GO:0044322,GO:0044390,GO:0044877,GO:0055085,GO:0061630,GO:0070534,GO:0070936,GO:0071712,GO:1904380,GO:2000785" ubiquitin-protein transferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|ubiquitin-dependent protein catabolic process|zinc ion binding|response to bacterium|negative regulation of autophagy|integral component of membrane|ubiquitin-dependent ERAD pathway|protein destabilization|mitochondrial membrane|ERAD pathway|identical protein binding|cellular protein catabolic process|endoplasmic reticulum quality control compartment|ubiquitin-like protein conjugating enzyme binding|protein-containing complex binding|transmembrane transport|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|ER-associated misfolded protein catabolic process|endoplasmic reticulum mannose trimming|regulation of autophagosome assembly hsa04141 Protein processing in endoplasmic reticulum RNF6 1292.973872 1444.094469 1141.853276 0.790705387 -0.338787842 0.159315736 1 17.42058492 13.54405189 6049 ring finger protein 6 "GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006511,GO:0016567,GO:0016605,GO:0030424,GO:0030517,GO:0031965,GO:0043231,GO:0044314,GO:0045893,GO:0046872,GO:0050681,GO:0060765,GO:0061630,GO:0070936,GO:0085020" "ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|ubiquitin-dependent protein catabolic process|protein ubiquitination|PML body|axon|negative regulation of axon extension|nuclear membrane|intracellular membrane-bounded organelle|protein K27-linked ubiquitination|positive regulation of transcription, DNA-templated|metal ion binding|androgen receptor binding|regulation of androgen receptor signaling pathway|ubiquitin protein ligase activity|protein K48-linked ubiquitination|protein K6-linked ubiquitination" RNF7 820.6090353 839.6140033 801.6040673 0.954729273 -0.0668364 0.793992723 1 16.83270331 15.80175362 9616 ring finger protein 7 "GO:0005507,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0008270,GO:0016567,GO:0018215,GO:0019788,GO:0031461,GO:0031466,GO:0043687,GO:0045116,GO:0051775,GO:0061630,GO:0061663,GO:0097602" copper ion binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|zinc ion binding|protein ubiquitination|protein phosphopantetheinylation|NEDD8 transferase activity|cullin-RING ubiquitin ligase complex|Cul5-RING ubiquitin ligase complex|post-translational protein modification|protein neddylation|response to redox state|ubiquitin protein ligase activity|NEDD8 ligase activity|cullin family protein binding "hsa04120,hsa05170" Ubiquitin mediated proteolysis|Human immunodeficiency virus 1 infection RNF8 421.7072334 397.4381032 445.9763636 1.122127848 0.166237057 0.564048413 1 8.874703392 9.791908944 9025 ring finger protein 8 "GO:0000151,GO:0000781,GO:0003682,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006302,GO:0006303,GO:0006511,GO:0006974,GO:0007049,GO:0007286,GO:0008270,GO:0010212,GO:0016032,GO:0016567,GO:0030496,GO:0031625,GO:0033522,GO:0033523,GO:0034244,GO:0035093,GO:0035861,GO:0036297,GO:0042393,GO:0042802,GO:0042803,GO:0043130,GO:0043486,GO:0045190,GO:0045739,GO:0051301,GO:0051865,GO:0061630,GO:0070534,GO:0070535,GO:0070936" "ubiquitin ligase complex|chromosome, telomeric region|chromatin binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytosol|double-strand break repair|double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|cell cycle|spermatid development|zinc ion binding|response to ionizing radiation|viral process|protein ubiquitination|midbody|ubiquitin protein ligase binding|histone H2A ubiquitination|histone H2B ubiquitination|negative regulation of transcription elongation from RNA polymerase II promoter|spermatogenesis, exchange of chromosomal proteins|site of double-strand break|interstrand cross-link repair|histone binding|identical protein binding|protein homodimerization activity|ubiquitin binding|histone exchange|isotype switching|positive regulation of DNA repair|cell division|protein autoubiquitination|ubiquitin protein ligase activity|protein K63-linked ubiquitination|histone H2A K63-linked ubiquitination|protein K48-linked ubiquitination" RNFT1 383.9397179 402.6401726 365.2392633 0.907110835 -0.140649258 0.635945862 1 10.12637417 9.032032751 51136 "ring finger protein, transmembrane 1" "GO:0005783,GO:0005789,GO:0016021,GO:0043130,GO:0046872,GO:0051865,GO:0061630,GO:1904294" endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|ubiquitin binding|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|positive regulation of ERAD pathway RNFT2 70.98150176 59.30359131 82.65941222 1.393834849 0.479059631 0.370525707 1 1.101226052 1.509242318 84900 "ring finger protein, transmembrane 2" "GO:0016021,GO:0016567,GO:0046872,GO:0061630" integral component of membrane|protein ubiquitination|metal ion binding|ubiquitin protein ligase activity RNGTT 606.7486478 549.33853 664.1587656 1.209015442 0.273832671 0.297525026 1 5.015772063 5.962670608 8732 RNA guanylyltransferase and 5'-phosphatase "GO:0004484,GO:0004651,GO:0004725,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0006366,GO:0006370,GO:0006396,GO:0008138,GO:0008192,GO:0016032,GO:0035335,GO:0050355,GO:0098507" mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein binding|GTP binding|nucleus|nucleoplasm|transcription by RNA polymerase II|7-methylguanosine mRNA capping|RNA processing|protein tyrosine/serine/threonine phosphatase activity|RNA guanylyltransferase activity|viral process|peptidyl-tyrosine dephosphorylation|triphosphatase activity|polynucleotide 5' dephosphorylation hsa03015 mRNA surveillance pathway RNH1 1958.546762 1910.199889 2006.893636 1.050619701 0.071240543 0.765062032 1 40.16700443 41.49408223 6050 ribonuclease/angiogenin inhibitor 1 "GO:0005515,GO:0005654,GO:0005829,GO:0006402,GO:0008428,GO:0032311,GO:0043086,GO:0045765,GO:0070062" protein binding|nucleoplasm|cytosol|mRNA catabolic process|ribonuclease inhibitor activity|angiogenin-PRI complex|negative regulation of catalytic activity|regulation of angiogenesis|extracellular exosome RNLS 4.523346619 5.202069413 3.844623824 0.739056617 -0.436243205 0.933440272 1 0.008345605 0.006064663 55328 "renalase, FAD dependent amine oxidase" "GO:0002931,GO:0005515,GO:0005576,GO:0005615,GO:0010459,GO:0016651,GO:0034356,GO:0045776,GO:0051379,GO:0055114,GO:0070404,GO:0071871,GO:0097621,GO:1902074" "response to ischemia|protein binding|extracellular region|extracellular space|negative regulation of heart rate|oxidoreductase activity, acting on NAD(P)H|NAD biosynthesis via nicotinamide riboside salvage pathway|negative regulation of blood pressure|epinephrine binding|oxidation-reduction process|NADH binding|response to epinephrine|monoamine oxidase activity|response to salt" RNMT 2002.33788 2063.140729 1941.535031 0.941057972 -0.087644495 0.712451228 1 15.64006091 14.4719148 8731 RNA guanine-7 methyltransferase "GO:0001650,GO:0003723,GO:0004482,GO:0005515,GO:0005634,GO:0005654,GO:0005845,GO:0006366,GO:0006370,GO:0031533,GO:0043235,GO:0106005,GO:1990830" fibrillar center|RNA binding|mRNA (guanine-N7-)-methyltransferase activity|protein binding|nucleus|nucleoplasm|mRNA cap binding complex|transcription by RNA polymerase II|7-methylguanosine mRNA capping|mRNA cap methyltransferase complex|receptor complex|RNA 5'-cap (guanine-N7)-methylation|cellular response to leukemia inhibitory factor hsa03015 mRNA surveillance pathway RNPC3 286.546549 293.3967149 279.6963832 0.953304413 -0.068991119 0.8395787 1 7.3031919 6.845662667 55599 "RNA binding region (RNP1, RRM) containing 3" "GO:0000398,GO:0005634,GO:0005654,GO:0005689,GO:0008380,GO:0030626,GO:0097157" "mRNA splicing, via spliceosome|nucleus|nucleoplasm|U12-type spliceosomal complex|RNA splicing|U12 snRNA binding|pre-mRNA intronic binding" RNPEP 1645.339483 1787.43105 1503.247915 0.841010295 -0.249804634 0.293489888 1 37.33538552 30.87401643 6051 arginyl aminopeptidase "GO:0004177,GO:0004301,GO:0005576,GO:0005615,GO:0005886,GO:0006508,GO:0008235,GO:0008270,GO:0070006,GO:0070062" aminopeptidase activity|epoxide hydrolase activity|extracellular region|extracellular space|plasma membrane|proteolysis|metalloexopeptidase activity|zinc ion binding|metalloaminopeptidase activity|extracellular exosome RNPEPL1 1152.899811 1110.121613 1195.678009 1.077069391 0.107111199 0.661425912 1 18.98274597 20.10360295 57140 arginyl aminopeptidase like 1 "GO:0006508,GO:0008270,GO:0070006" proteolysis|zinc ion binding|metalloaminopeptidase activity RNPS1 2738.985392 2755.015961 2722.954823 0.988362631 -0.01688763 0.944702346 1 51.89909578 50.43677236 10921 RNA binding protein with serine rich domain 1 "GO:0000184,GO:0000381,GO:0000398,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0006405,GO:0006406,GO:0008380,GO:0016607,GO:0031124,GO:0035145,GO:0043065,GO:0048025,GO:0061574" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|RNA export from nucleus|mRNA export from nucleus|RNA splicing|nuclear speck|mRNA 3'-end processing|exon-exon junction complex|positive regulation of apoptotic process|negative regulation of mRNA splicing, via spliceosome|ASAP complex" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway RO60 938.0820692 1009.201466 866.9626723 0.859058078 -0.219172424 0.376234364 1 5.523456816 4.665569549 6738 "Ro60, Y RNA binding protein" "GO:0002520,GO:0003723,GO:0005654,GO:0005829,GO:0006383,GO:0007224,GO:0009411,GO:0010468,GO:0030620,GO:0035457,GO:0046872,GO:0060271,GO:1990904" immune system development|RNA binding|nucleoplasm|cytosol|transcription by RNA polymerase III|smoothened signaling pathway|response to UV|regulation of gene expression|U2 snRNA binding|cellular response to interferon-alpha|metal ion binding|cilium assembly|ribonucleoprotein complex hsa05322 Systemic lupus erythematosus ROBO1 1153.810663 1234.971279 1072.650047 0.868562747 -0.203298018 0.403269757 1 8.030723451 6.858466913 6091 roundabout guidance receptor 1 "GO:0002042,GO:0003148,GO:0003180,GO:0003184,GO:0003272,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0006919,GO:0007155,GO:0007156,GO:0007399,GO:0007411,GO:0008046,GO:0009986,GO:0010628,GO:0010629,GO:0016199,GO:0021836,GO:0030275,GO:0030336,GO:0030424,GO:0033116,GO:0033600,GO:0035025,GO:0035385,GO:0035481,GO:0035904,GO:0042802,GO:0043406,GO:0050772,GO:0050925,GO:0060412,GO:0070100,GO:1900748" cell migration involved in sprouting angiogenesis|outflow tract septum morphogenesis|aortic valve morphogenesis|pulmonary valve morphogenesis|endocardial cushion formation|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|nervous system development|axon guidance|axon guidance receptor activity|cell surface|positive regulation of gene expression|negative regulation of gene expression|axon midline choice point recognition|chemorepulsion involved in postnatal olfactory bulb interneuron migration|LRR domain binding|negative regulation of cell migration|axon|endoplasmic reticulum-Golgi intermediate compartment membrane|negative regulation of mammary gland epithelial cell proliferation|positive regulation of Rho protein signal transduction|Roundabout signaling pathway|positive regulation of Notch signaling pathway involved in heart induction|aorta development|identical protein binding|positive regulation of MAP kinase activity|positive regulation of axonogenesis|negative regulation of negative chemotaxis|ventricular septum morphogenesis|negative regulation of chemokine-mediated signaling pathway|positive regulation of vascular endothelial growth factor signaling pathway hsa04360 Axon guidance ROBO2 201.6880366 185.1936711 218.182402 1.178130984 0.236499946 0.519905647 1 0.94887153 1.099188491 6092 roundabout guidance receptor 2 "GO:0001656,GO:0001657,GO:0003148,GO:0003180,GO:0003184,GO:0003272,GO:0005515,GO:0005886,GO:0007156,GO:0007411,GO:0007417,GO:0007420,GO:0008046,GO:0009986,GO:0016021,GO:0016199,GO:0021891,GO:0030673,GO:0031290,GO:0032870,GO:0035481,GO:0035904,GO:0042802,GO:0050772,GO:0050925,GO:0051964,GO:0060412,GO:0061364,GO:0070062" metanephros development|ureteric bud development|outflow tract septum morphogenesis|aortic valve morphogenesis|pulmonary valve morphogenesis|endocardial cushion formation|protein binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|axon guidance|central nervous system development|brain development|axon guidance receptor activity|cell surface|integral component of membrane|axon midline choice point recognition|olfactory bulb interneuron development|axolemma|retinal ganglion cell axon guidance|cellular response to hormone stimulus|positive regulation of Notch signaling pathway involved in heart induction|aorta development|identical protein binding|positive regulation of axonogenesis|negative regulation of negative chemotaxis|negative regulation of synapse assembly|ventricular septum morphogenesis|apoptotic process involved in luteolysis|extracellular exosome hsa04360 Axon guidance ROBO3 1142.881901 1124.687407 1161.076395 1.032354757 0.045938822 0.853449663 1 12.41673559 12.60397621 64221 roundabout guidance receptor 3 "GO:0005515,GO:0005886,GO:0007156,GO:0007411,GO:0016021,GO:0016199,GO:0030424,GO:0061642,GO:0070593,GO:0071679,GO:0098632" protein binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|axon guidance|integral component of membrane|axon midline choice point recognition|axon|chemoattraction of axon|dendrite self-avoidance|commissural neuron axon guidance|cell-cell adhesion mediator activity hsa04360 Axon guidance ROBO4 93.90520573 118.6071826 69.20322883 0.583465751 -0.777280123 0.103980556 1 1.50531447 0.863602285 54538 roundabout guidance receptor 4 "GO:0001525,GO:0005515,GO:0005886,GO:0007156,GO:0007411,GO:0016021,GO:0030334,GO:0030424,GO:0038023,GO:0061028,GO:0070062,GO:0070593,GO:0098632" angiogenesis|protein binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|axon guidance|integral component of membrane|regulation of cell migration|axon|signaling receptor activity|establishment of endothelial barrier|extracellular exosome|dendrite self-avoidance|cell-cell adhesion mediator activity ROCK1 2149.612394 2119.323079 2179.901708 1.028583952 0.04065955 0.865294971 1 11.97378547 12.10995127 6093 Rho associated coiled-coil containing protein kinase 1 "GO:0000139,GO:0000281,GO:0001726,GO:0003180,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005576,GO:0005737,GO:0005814,GO:0005829,GO:0005856,GO:0005886,GO:0006468,GO:0006915,GO:0006939,GO:0007159,GO:0007165,GO:0007186,GO:0007249,GO:0007266,GO:0010494,GO:0010506,GO:0010508,GO:0010613,GO:0010628,GO:0010951,GO:0016525,GO:0018105,GO:0018107,GO:0019828,GO:0022614,GO:0030027,GO:0030036,GO:0030155,GO:0030334,GO:0030866,GO:0031032,GO:0031175,GO:0032059,GO:0032091,GO:0032956,GO:0034774,GO:0035509,GO:0042326,GO:0043312,GO:0043410,GO:0045616,GO:0045664,GO:0046872,GO:0048010,GO:0048013,GO:0048156,GO:0048598,GO:0050321,GO:0050900,GO:0050901,GO:0051045,GO:0051451,GO:0051492,GO:0051893,GO:0051894,GO:0061157,GO:0070168,GO:0070507,GO:0071559,GO:0072518,GO:0072659,GO:0090521,GO:0097746,GO:0106003,GO:0106310,GO:0106311,GO:0110061,GO:0140058,GO:1900223,GO:1900242,GO:1901888,GO:1902003,GO:1902430,GO:1902992,GO:1903140,GO:1903347,GO:1905205,GO:1990776,GO:2000114,GO:2000145" Golgi membrane|mitotic cytokinesis|ruffle|aortic valve morphogenesis|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|extracellular region|cytoplasm|centriole|cytosol|cytoskeleton|plasma membrane|protein phosphorylation|apoptotic process|smooth muscle contraction|leukocyte cell-cell adhesion|signal transduction|G protein-coupled receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|Rho protein signal transduction|cytoplasmic stress granule|regulation of autophagy|positive regulation of autophagy|positive regulation of cardiac muscle hypertrophy|positive regulation of gene expression|negative regulation of endopeptidase activity|negative regulation of angiogenesis|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|aspartic-type endopeptidase inhibitor activity|membrane to membrane docking|lamellipodium|actin cytoskeleton organization|regulation of cell adhesion|regulation of cell migration|cortical actin cytoskeleton organization|actomyosin structure organization|neuron projection development|bleb|negative regulation of protein binding|regulation of actin cytoskeleton organization|secretory granule lumen|negative regulation of myosin-light-chain-phosphatase activity|negative regulation of phosphorylation|neutrophil degranulation|positive regulation of MAPK cascade|regulation of keratinocyte differentiation|regulation of neuron differentiation|metal ion binding|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|tau protein binding|embryonic morphogenesis|tau-protein kinase activity|leukocyte migration|leukocyte tethering or rolling|negative regulation of membrane protein ectodomain proteolysis|myoblast migration|regulation of stress fiber assembly|regulation of focal adhesion assembly|positive regulation of focal adhesion assembly|mRNA destabilization|negative regulation of biomineral tissue development|regulation of microtubule cytoskeleton organization|response to transforming growth factor beta|Rho-dependent protein serine/threonine kinase activity|protein localization to plasma membrane|glomerular visceral epithelial cell migration|blood vessel diameter maintenance|amyloid-beta complex|protein serine kinase activity|protein threonine kinase activity|regulation of angiotensin-activated signaling pathway|neuron projection arborization|positive regulation of amyloid-beta clearance|regulation of synaptic vesicle endocytosis|regulation of cell junction assembly|regulation of amyloid-beta formation|negative regulation of amyloid-beta formation|negative regulation of amyloid precursor protein catabolic process|regulation of establishment of endothelial barrier|negative regulation of bicellular tight junction assembly|positive regulation of connective tissue replacement|response to angiotensin|regulation of establishment of cell polarity|regulation of cell motility "hsa04022,hsa04024,hsa04062,hsa04071,hsa04270,hsa04350,hsa04360,hsa04510,hsa04530,hsa04611,hsa04670,hsa04810,hsa04921,hsa05130,hsa05131,hsa05135,hsa05163,hsa05200,hsa05205,hsa05206" cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Vascular smooth muscle contraction|TGF-beta signaling pathway|Axon guidance|Focal adhesion|Tight junction|Platelet activation|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Yersinia infection|Human cytomegalovirus infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer ROCK2 1722.29674 1726.046631 1718.546849 0.995654937 -0.00628226 0.98163207 1 9.206069995 9.012687286 9475 Rho associated coiled-coil containing protein kinase 2 "GO:0000281,GO:0001934,GO:0002931,GO:0003180,GO:0003723,GO:0004674,GO:0005198,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0005856,GO:0005886,GO:0006468,GO:0006939,GO:0007186,GO:0007249,GO:0007266,GO:0010595,GO:0010613,GO:0010628,GO:0010629,GO:0010825,GO:0016525,GO:0018105,GO:0018107,GO:0030155,GO:0030335,GO:0030866,GO:0031032,GO:0031644,GO:0032723,GO:0032956,GO:0035509,GO:0036464,GO:0039694,GO:0042752,GO:0043410,GO:0045019,GO:0045616,GO:0046872,GO:0048010,GO:0048013,GO:0048156,GO:0048511,GO:0048598,GO:0050321,GO:0051246,GO:0051298,GO:0051492,GO:0051496,GO:0051893,GO:0061157,GO:0070168,GO:0071394,GO:0071559,GO:0072518,GO:0072659,GO:0090271,GO:0097746,GO:0106310,GO:0106311,GO:0110061,GO:0150033,GO:1900037,GO:1901888,GO:1902004,GO:1902961,GO:1902966,GO:1902993,GO:1903140,GO:1903347,GO:1905145,GO:1905205,GO:1990776,GO:2000114,GO:2000145" mitotic cytokinesis|positive regulation of protein phosphorylation|response to ischemia|aortic valve morphogenesis|RNA binding|protein serine/threonine kinase activity|structural molecule activity|protein binding|ATP binding|nucleus|cytoplasm|centrosome|cytosol|cytoskeleton|plasma membrane|protein phosphorylation|smooth muscle contraction|G protein-coupled receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|Rho protein signal transduction|positive regulation of endothelial cell migration|positive regulation of cardiac muscle hypertrophy|positive regulation of gene expression|negative regulation of gene expression|positive regulation of centrosome duplication|negative regulation of angiogenesis|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of cell adhesion|positive regulation of cell migration|cortical actin cytoskeleton organization|actomyosin structure organization|regulation of nervous system process|positive regulation of connective tissue growth factor production|regulation of actin cytoskeleton organization|negative regulation of myosin-light-chain-phosphatase activity|cytoplasmic ribonucleoprotein granule|viral RNA genome replication|regulation of circadian rhythm|positive regulation of MAPK cascade|negative regulation of nitric oxide biosynthetic process|regulation of keratinocyte differentiation|metal ion binding|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|tau protein binding|rhythmic process|embryonic morphogenesis|tau-protein kinase activity|regulation of protein metabolic process|centrosome duplication|regulation of stress fiber assembly|positive regulation of stress fiber assembly|regulation of focal adhesion assembly|mRNA destabilization|negative regulation of biomineral tissue development|cellular response to testosterone stimulus|response to transforming growth factor beta|Rho-dependent protein serine/threonine kinase activity|protein localization to plasma membrane|positive regulation of fibroblast growth factor production|blood vessel diameter maintenance|protein serine kinase activity|protein threonine kinase activity|regulation of angiotensin-activated signaling pathway|negative regulation of protein localization to lysosome|regulation of cellular response to hypoxia|regulation of cell junction assembly|positive regulation of amyloid-beta formation|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of protein localization to early endosome|positive regulation of amyloid precursor protein catabolic process|regulation of establishment of endothelial barrier|negative regulation of bicellular tight junction assembly|cellular response to acetylcholine|positive regulation of connective tissue replacement|response to angiotensin|regulation of establishment of cell polarity|regulation of cell motility "hsa04022,hsa04024,hsa04062,hsa04071,hsa04270,hsa04310,hsa04360,hsa04510,hsa04530,hsa04611,hsa04670,hsa04810,hsa04921,hsa05130,hsa05131,hsa05132,hsa05135,hsa05163,hsa05200,hsa05205" cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Vascular smooth muscle contraction|Wnt signaling pathway|Axon guidance|Focal adhesion|Tight junction|Platelet activation|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Human cytomegalovirus infection|Pathways in cancer|Proteoglycans in cancer ROGDI 299.1208344 295.4775427 302.7641261 1.024660363 0.035145789 0.92229959 1 11.11282127 11.19632367 79641 rogdi atypical leucine zipper "GO:0005515,GO:0005634,GO:0005635,GO:0007035,GO:0007420,GO:0008021,GO:0008284,GO:0022008,GO:0030097,GO:0030424,GO:0030425,GO:0032502,GO:0042475,GO:0043204,GO:0043291" protein binding|nucleus|nuclear envelope|vacuolar acidification|brain development|synaptic vesicle|positive regulation of cell population proliferation|neurogenesis|hemopoiesis|axon|dendrite|developmental process|odontogenesis of dentin-containing tooth|perikaryon|RAVE complex ROM1 21.97763926 21.84869154 22.10658699 1.011803702 0.016929423 1 1 0.858633661 0.854231049 6094 retinal outer segment membrane protein 1 "GO:0005515,GO:0005887,GO:0007155,GO:0007601,GO:0010468,GO:0035845,GO:0042622,GO:0042803,GO:0050908,GO:0051260,GO:0051291,GO:0060219,GO:0061298,GO:1903546" protein binding|integral component of plasma membrane|cell adhesion|visual perception|regulation of gene expression|photoreceptor cell outer segment organization|photoreceptor outer segment membrane|protein homodimerization activity|detection of light stimulus involved in visual perception|protein homooligomerization|protein heterooligomerization|camera-type eye photoreceptor cell differentiation|retina vasculature development in camera-type eye|protein localization to photoreceptor outer segment ROMO1 1053.574884 924.9279417 1182.221826 1.278177221 0.354087881 0.147949432 1 107.0752805 134.5709978 140823 reactive oxygen species modulator 1 "GO:0003674,GO:0005515,GO:0005739,GO:0005744,GO:0008284,GO:0016021,GO:0030150,GO:0031640,GO:0034614,GO:0042742,GO:0045039,GO:0050829,GO:0050830,GO:0051838,GO:0061844,GO:0090399,GO:2000379" molecular_function|protein binding|mitochondrion|TIM23 mitochondrial import inner membrane translocase complex|positive regulation of cell population proliferation|integral component of membrane|protein import into mitochondrial matrix|killing of cells of other organism|cellular response to reactive oxygen species|defense response to bacterium|protein insertion into mitochondrial inner membrane|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|cytolysis by host of symbiont cells|antimicrobial humoral immune response mediated by antimicrobial peptide|replicative senescence|positive regulation of reactive oxygen species metabolic process ROPN1B 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.127795876 152015 rhophilin associated tail protein 1B "GO:0001932,GO:0005515,GO:0005737,GO:0007266,GO:0007283,GO:0007340,GO:0007342,GO:0030159,GO:0030317,GO:0031514,GO:0044782,GO:0046982,GO:0048240,GO:0061512,GO:0061640,GO:0098609" regulation of protein phosphorylation|protein binding|cytoplasm|Rho protein signal transduction|spermatogenesis|acrosome reaction|fusion of sperm to egg plasma membrane involved in single fertilization|signaling receptor complex adaptor activity|flagellated sperm motility|motile cilium|cilium organization|protein heterodimerization activity|sperm capacitation|protein localization to cilium|cytoskeleton-dependent cytokinesis|cell-cell adhesion ROPN1L 7.203639252 12.48496659 1.922311912 0.153970129 -2.699277611 0.067487328 1 0.42575062 0.064455939 83853 rhophilin associated tail protein 1 like "GO:0001932,GO:0003351,GO:0005515,GO:0005576,GO:0005737,GO:0005929,GO:0030317,GO:0031514,GO:0042802,GO:0048240" regulation of protein phosphorylation|epithelial cilium movement involved in extracellular fluid movement|protein binding|extracellular region|cytoplasm|cilium|flagellated sperm motility|motile cilium|identical protein binding|sperm capacitation ROR1 56.12321341 60.34400519 51.90242162 0.860108994 -0.217408603 0.727932698 1 0.346657551 0.293173919 4919 receptor tyrosine kinase like orphan receptor 1 "GO:0001725,GO:0004714,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0005887,GO:0007169,GO:0007275,GO:0007605,GO:0009986,GO:0010976,GO:0014002,GO:0014068,GO:0017147,GO:0018108,GO:0033674,GO:0042813,GO:0043123,GO:0043235,GO:0043410,GO:0043679,GO:0048839,GO:0051092,GO:0060071,GO:0070374,GO:1904929" "stress fiber|transmembrane receptor protein tyrosine kinase activity|protein binding|ATP binding|cytoplasm|plasma membrane|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|sensory perception of sound|cell surface|positive regulation of neuron projection development|astrocyte development|positive regulation of phosphatidylinositol 3-kinase signaling|Wnt-protein binding|peptidyl-tyrosine phosphorylation|positive regulation of kinase activity|Wnt-activated receptor activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|receptor complex|positive regulation of MAPK cascade|axon terminus|inner ear development|positive regulation of NF-kappaB transcription factor activity|Wnt signaling pathway, planar cell polarity pathway|positive regulation of ERK1 and ERK2 cascade|coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway" hsa04310 Wnt signaling pathway ROR2 5.405244648 3.121241648 7.689247648 2.463522058 1.300722389 0.455625732 1 0.021920638 0.053098326 4920 receptor tyrosine kinase like orphan receptor 2 "GO:0001502,GO:0001756,GO:0004714,GO:0005109,GO:0005515,GO:0005524,GO:0005874,GO:0005886,GO:0005887,GO:0007165,GO:0007169,GO:0007223,GO:0007224,GO:0007254,GO:0007275,GO:0008285,GO:0009986,GO:0010976,GO:0014002,GO:0014068,GO:0017147,GO:0018108,GO:0030282,GO:0030335,GO:0030425,GO:0030509,GO:0030538,GO:0030539,GO:0030669,GO:0031435,GO:0033674,GO:0042472,GO:0042733,GO:0043025,GO:0043235,GO:0043410,GO:0043507,GO:0045165,GO:0045651,GO:0045893,GO:0046872,GO:0051968,GO:0060071,GO:0060395,GO:0070374,GO:0090090,GO:0090263,GO:1900020,GO:1904929,GO:1905517" "cartilage condensation|somitogenesis|transmembrane receptor protein tyrosine kinase activity|frizzled binding|protein binding|ATP binding|microtubule|plasma membrane|integral component of plasma membrane|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|Wnt signaling pathway, calcium modulating pathway|smoothened signaling pathway|JNK cascade|multicellular organism development|negative regulation of cell population proliferation|cell surface|positive regulation of neuron projection development|astrocyte development|positive regulation of phosphatidylinositol 3-kinase signaling|Wnt-protein binding|peptidyl-tyrosine phosphorylation|bone mineralization|positive regulation of cell migration|dendrite|BMP signaling pathway|embryonic genitalia morphogenesis|male genitalia development|clathrin-coated endocytic vesicle membrane|mitogen-activated protein kinase kinase kinase binding|positive regulation of kinase activity|inner ear morphogenesis|embryonic digit morphogenesis|neuronal cell body|receptor complex|positive regulation of MAPK cascade|positive regulation of JUN kinase activity|cell fate commitment|positive regulation of macrophage differentiation|positive regulation of transcription, DNA-templated|metal ion binding|positive regulation of synaptic transmission, glutamatergic|Wnt signaling pathway, planar cell polarity pathway|SMAD protein signal transduction|positive regulation of ERK1 and ERK2 cascade|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|positive regulation of protein kinase C activity|coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway|macrophage migration" hsa04310 Wnt signaling pathway RORA 47.88419069 33.29324424 62.47513714 1.876510943 0.908052703 0.137757363 1 0.06856258 0.126505507 6095 RAR related orphan receptor A "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001222,GO:0001223,GO:0001525,GO:0003677,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0006367,GO:0006805,GO:0006809,GO:0008013,GO:0008134,GO:0008142,GO:0008270,GO:0008589,GO:0010575,GO:0010906,GO:0019218,GO:0019221,GO:0021702,GO:0021930,GO:0030522,GO:0032922,GO:0036315,GO:0042632,GO:0042692,GO:0042753,GO:0043030,GO:0043124,GO:0043565,GO:0045599,GO:0045893,GO:0045944,GO:0046068,GO:0050728,GO:0070328,GO:0071347,GO:0071356,GO:0071456,GO:0072539,GO:0098531" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|transcription corepressor binding|transcription coactivator binding|angiogenesis|DNA binding|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|xenobiotic metabolic process|nitric oxide biosynthetic process|beta-catenin binding|transcription factor binding|oxysterol binding|zinc ion binding|regulation of smoothened signaling pathway|positive regulation of vascular endothelial growth factor production|regulation of glucose metabolic process|regulation of steroid metabolic process|cytokine-mediated signaling pathway|cerebellar Purkinje cell differentiation|cerebellar granule cell precursor proliferation|intracellular receptor signaling pathway|circadian regulation of gene expression|cellular response to sterol|cholesterol homeostasis|muscle cell differentiation|positive regulation of circadian rhythm|regulation of macrophage activation|negative regulation of I-kappaB kinase/NF-kappaB signaling|sequence-specific DNA binding|negative regulation of fat cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cGMP metabolic process|negative regulation of inflammatory response|triglyceride homeostasis|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to hypoxia|T-helper 17 cell differentiation|ligand-activated transcription factor activity" "hsa04659,hsa04710,hsa05017,hsa05321" Th17 cell differentiation|Circadian rhythm|Spinocerebellar ataxia|Inflammatory bowel disease ROR_rcpt RORB 418.1947325 368.3065145 468.0829506 1.270905977 0.345857302 0.226734825 1 2.029094844 2.535636228 6096 RAR related orphan receptor B "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0006367,GO:0007186,GO:0007601,GO:0008134,GO:0008270,GO:0008502,GO:0030522,GO:0035881,GO:0042462,GO:0042752,GO:0045668,GO:0045892,GO:0045893,GO:0045944,GO:0046548,GO:0046549,GO:0048511,GO:0060041,GO:0071300,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|G protein-coupled receptor signaling pathway|visual perception|transcription factor binding|zinc ion binding|melatonin receptor activity|intracellular receptor signaling pathway|amacrine cell differentiation|eye photoreceptor cell development|regulation of circadian rhythm|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|retinal rod cell development|retinal cone cell development|rhythmic process|retina development in camera-type eye|cellular response to retinoic acid|sequence-specific double-stranded DNA binding" hsa04710 Circadian rhythm ROS1 25.33162427 46.81862472 3.844623824 0.082117402 -3.606168206 8.19E-05 0.032569251 0.187092771 0.015106484 6098 "ROS proto-oncogene 1, receptor tyrosine kinase" "GO:0001558,GO:0002066,GO:0004713,GO:0004714,GO:0005515,GO:0005524,GO:0005887,GO:0006468,GO:0007169,GO:0007275,GO:0007283,GO:0009986,GO:0010467,GO:0010629,GO:0010966,GO:0016020,GO:0019903,GO:0030154,GO:0032006,GO:0033674,GO:0038083,GO:0043235,GO:0048471,GO:0070372" regulation of cell growth|columnar/cuboidal epithelial cell development|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|protein binding|ATP binding|integral component of plasma membrane|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|spermatogenesis|cell surface|gene expression|negative regulation of gene expression|regulation of phosphate transport|membrane|protein phosphatase binding|cell differentiation|regulation of TOR signaling|positive regulation of kinase activity|peptidyl-tyrosine autophosphorylation|receptor complex|perinuclear region of cytoplasm|regulation of ERK1 and ERK2 cascade RP1 108.6842362 115.485941 101.8825313 0.882207223 -0.180810522 0.704968712 1 0.437514901 0.379519974 6101 RP1 axonemal microtubule associated "GO:0001750,GO:0001917,GO:0005515,GO:0005874,GO:0005875,GO:0005930,GO:0007601,GO:0007603,GO:0008017,GO:0032391,GO:0035082,GO:0035556,GO:0035845,GO:0042461,GO:0045494,GO:0046548,GO:0046549,GO:0060041,GO:0071482,GO:0097542,GO:1902857" "photoreceptor outer segment|photoreceptor inner segment|protein binding|microtubule|microtubule associated complex|axoneme|visual perception|phototransduction, visible light|microtubule binding|photoreceptor connecting cilium|axoneme assembly|intracellular signal transduction|photoreceptor cell outer segment organization|photoreceptor cell development|photoreceptor cell maintenance|retinal rod cell development|retinal cone cell development|retina development in camera-type eye|cellular response to light stimulus|ciliary tip|positive regulation of non-motile cilium assembly" RP1L1 13.60966882 16.64662212 10.57271552 0.635126781 -0.654883491 0.544268462 1 0.110855956 0.069229411 94137 RP1 like 1 "GO:0001750,GO:0005874,GO:0005930,GO:0007601,GO:0032391,GO:0035082,GO:0035556,GO:0042461,GO:0045494,GO:0060041" photoreceptor outer segment|microtubule|axoneme|visual perception|photoreceptor connecting cilium|axoneme assembly|intracellular signal transduction|photoreceptor cell development|photoreceptor cell maintenance|retina development in camera-type eye RP2 734.4226453 747.0171677 721.828123 0.966280501 -0.049486046 0.850788453 1 10.77484683 10.23730163 6102 RP2 activator of ARL3 GTPase "GO:0000287,GO:0000902,GO:0005096,GO:0005515,GO:0005525,GO:0005654,GO:0005737,GO:0005794,GO:0005814,GO:0005886,GO:0005929,GO:0006457,GO:0006892,GO:0007023,GO:0007601,GO:0015031,GO:0016604,GO:0031410,GO:0036064,GO:0043547,GO:0051082,GO:0070062,GO:1990075" magnesium ion binding|cell morphogenesis|GTPase activator activity|protein binding|GTP binding|nucleoplasm|cytoplasm|Golgi apparatus|centriole|plasma membrane|cilium|protein folding|post-Golgi vesicle-mediated transport|post-chaperonin tubulin folding pathway|visual perception|protein transport|nuclear body|cytoplasmic vesicle|ciliary basal body|positive regulation of GTPase activity|unfolded protein binding|extracellular exosome|periciliary membrane compartment RP9 204.566474 197.6786377 211.4543103 1.069687209 0.097188995 0.799187906 1 5.926823357 6.233758382 6100 RP9 pre-mRNA splicing factor "GO:0003723,GO:0005515,GO:0005634,GO:0005785,GO:0008380,GO:0046872,GO:0050890" RNA binding|protein binding|nucleus|signal recognition particle receptor complex|RNA splicing|metal ion binding|cognition hsa03040 Spliceosome RPA1 3258.922419 3371.981394 3145.863444 0.932942112 -0.100140528 0.673349746 1 52.63423502 48.28299384 6117 replication protein A1 "GO:0000082,GO:0000723,GO:0000724,GO:0000781,GO:0003684,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005662,GO:0006260,GO:0006261,GO:0006268,GO:0006281,GO:0006283,GO:0006284,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006297,GO:0006298,GO:0006310,GO:0006974,GO:0007004,GO:0016605,GO:0019985,GO:0032201,GO:0033683,GO:0034502,GO:0036297,GO:0042276,GO:0042769,GO:0043047,GO:0046872,GO:0051321,GO:0070987,GO:0090734,GO:0098505,GO:1900034,GO:1901796" "G1/S transition of mitotic cell cycle|telomere maintenance|double-strand break repair via homologous recombination|chromosome, telomeric region|damaged DNA binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|DNA replication factor A complex|DNA replication|DNA-dependent DNA replication|DNA unwinding involved in DNA replication|DNA repair|transcription-coupled nucleotide-excision repair|base-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|mismatch repair|DNA recombination|cellular response to DNA damage stimulus|telomere maintenance via telomerase|PML body|translesion synthesis|telomere maintenance via semi-conservative replication|nucleotide-excision repair, DNA incision|protein localization to chromosome|interstrand cross-link repair|error-prone translesion synthesis|DNA damage response, detection of DNA damage|single-stranded telomeric DNA binding|metal ion binding|meiotic cell cycle|error-free translesion synthesis|site of DNA damage|G-rich strand telomeric DNA binding|regulation of cellular response to heat|regulation of signal transduction by p53 class mediator" "hsa03030,hsa03420,hsa03430,hsa03440,hsa03460" DNA replication|Nucleotide excision repair|Mismatch repair|Homologous recombination|Fanconi anemia pathway RPA2 713.6043069 730.3705456 696.8380681 0.954088404 -0.067805145 0.795344048 1 20.93369154 19.63837807 6118 replication protein A2 "GO:0000082,GO:0000723,GO:0000724,GO:0000781,GO:0000785,GO:0003684,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005662,GO:0006260,GO:0006283,GO:0006284,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006297,GO:0006298,GO:0010569,GO:0016604,GO:0016605,GO:0019899,GO:0019903,GO:0019985,GO:0031571,GO:0031625,GO:0032201,GO:0033683,GO:0034502,GO:0035861,GO:0036297,GO:0042276,GO:0042769,GO:0047485,GO:0070987,GO:0098505,GO:1900034,GO:1901796,GO:2000001" "G1/S transition of mitotic cell cycle|telomere maintenance|double-strand break repair via homologous recombination|chromosome, telomeric region|chromatin|damaged DNA binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|DNA replication factor A complex|DNA replication|transcription-coupled nucleotide-excision repair|base-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|mismatch repair|regulation of double-strand break repair via homologous recombination|nuclear body|PML body|enzyme binding|protein phosphatase binding|translesion synthesis|mitotic G1 DNA damage checkpoint|ubiquitin protein ligase binding|telomere maintenance via semi-conservative replication|nucleotide-excision repair, DNA incision|protein localization to chromosome|site of double-strand break|interstrand cross-link repair|error-prone translesion synthesis|DNA damage response, detection of DNA damage|protein N-terminus binding|error-free translesion synthesis|G-rich strand telomeric DNA binding|regulation of cellular response to heat|regulation of signal transduction by p53 class mediator|regulation of DNA damage checkpoint" "hsa03030,hsa03420,hsa03430,hsa03440,hsa03460" DNA replication|Nucleotide excision repair|Mismatch repair|Homologous recombination|Fanconi anemia pathway RPA3 915.2438824 737.6534428 1092.834322 1.481501012 0.567059612 0.022306574 0.822216713 19.48871708 28.38941098 6119 replication protein A3 "GO:0000082,GO:0000723,GO:0000724,GO:0003684,GO:0003697,GO:0005515,GO:0005654,GO:0005662,GO:0006260,GO:0006283,GO:0006284,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006297,GO:0006298,GO:0007346,GO:0019985,GO:0032201,GO:0033683,GO:0035861,GO:0036297,GO:0042127,GO:0042276,GO:0042769,GO:0070987,GO:1900034,GO:1901796" "G1/S transition of mitotic cell cycle|telomere maintenance|double-strand break repair via homologous recombination|damaged DNA binding|single-stranded DNA binding|protein binding|nucleoplasm|DNA replication factor A complex|DNA replication|transcription-coupled nucleotide-excision repair|base-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|mismatch repair|regulation of mitotic cell cycle|translesion synthesis|telomere maintenance via semi-conservative replication|nucleotide-excision repair, DNA incision|site of double-strand break|interstrand cross-link repair|regulation of cell population proliferation|error-prone translesion synthesis|DNA damage response, detection of DNA damage|error-free translesion synthesis|regulation of cellular response to heat|regulation of signal transduction by p53 class mediator" "hsa03030,hsa03420,hsa03430,hsa03440,hsa03460" DNA replication|Nucleotide excision repair|Mismatch repair|Homologous recombination|Fanconi anemia pathway RPA4 3.403674809 1.040413883 5.766935736 5.54292463 2.470647391 0.304382079 1 0.035592934 0.193987586 29935 replication protein A4 "GO:0000077,GO:0000082,GO:0000724,GO:0000781,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005662,GO:0006260,GO:0006270,GO:0006289,GO:0033260,GO:0035861" "DNA damage checkpoint|G1/S transition of mitotic cell cycle|double-strand break repair via homologous recombination|chromosome, telomeric region|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|DNA replication factor A complex|DNA replication|DNA replication initiation|nucleotide-excision repair|nuclear DNA replication|site of double-strand break" "hsa03030,hsa03420,hsa03430,hsa03440,hsa03460" DNA replication|Nucleotide excision repair|Mismatch repair|Homologous recombination|Fanconi anemia pathway RPAIN 619.7733286 626.3291574 613.2174999 0.979065868 -0.030522173 0.91340209 1 13.67118036 13.16100645 84268 RPA interacting protein "GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006261,GO:0006281,GO:0006310,GO:0006606,GO:0016605,GO:0044877,GO:0046872" fibrillar center|protein binding|nucleus|nucleoplasm|cytoplasm|DNA-dependent DNA replication|DNA repair|DNA recombination|protein import into nucleus|PML body|protein-containing complex binding|metal ion binding RPAP1 502.6267729 541.015219 464.2383267 0.858087371 -0.220803544 0.420479529 1 5.810623444 4.902588257 26015 RNA polymerase II associated protein 1 "GO:0003677,GO:0003899,GO:0005515,GO:0005634,GO:0006366" DNA binding|DNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|transcription by RNA polymerase II RPAP2 446.285293 525.4090107 367.1615752 0.69881096 -0.51702586 0.065529473 1 1.310102006 0.90019376 79871 RNA polymerase II associated protein 2 "GO:0004722,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0008420,GO:0009301,GO:0016591,GO:0042795,GO:0043175,GO:0046872,GO:0070940,GO:0106306,GO:0106307" "protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|RNA polymerase II CTD heptapeptide repeat phosphatase activity|snRNA transcription|RNA polymerase II, holoenzyme|snRNA transcription by RNA polymerase II|RNA polymerase core enzyme binding|metal ion binding|dephosphorylation of RNA polymerase II C-terminal domain|protein serine phosphatase activity|protein threonine phosphatase activity" RPAP3 927.737681 939.493736 915.9816261 0.974973638 -0.036564883 0.886870613 1 11.55543996 11.07772391 79657 RNA polymerase II associated protein 3 "GO:0005515,GO:0005829,GO:0097255" protein binding|cytosol|R2TP complex RPE 1929.246597 1872.744989 1985.748205 1.060340952 0.084528238 0.722564569 1 22.03857951 22.97736972 6120 ribulose-5-phosphate-3-epimerase "GO:0004750,GO:0005515,GO:0005829,GO:0005975,GO:0006098,GO:0009052,GO:0019323,GO:0042802,GO:0042803,GO:0044262,GO:0046872,GO:0070062" "ribulose-phosphate 3-epimerase activity|protein binding|cytosol|carbohydrate metabolic process|pentose-phosphate shunt|pentose-phosphate shunt, non-oxidative branch|pentose catabolic process|identical protein binding|protein homodimerization activity|cellular carbohydrate metabolic process|metal ion binding|extracellular exosome" "hsa00030,hsa00040" Pentose phosphate pathway|Pentose and glucuronate interconversions RPEL1 3.403674809 1.040413883 5.766935736 5.54292463 2.470647391 0.304382079 1 0.026068064 0.142075415 729020 ribulose-5-phosphate-3-epimerase like 1 "GO:0004750,GO:0005829,GO:0006098,GO:0009052,GO:0019323,GO:0044262,GO:0046872" "ribulose-phosphate 3-epimerase activity|cytosol|pentose-phosphate shunt|pentose-phosphate shunt, non-oxidative branch|pentose catabolic process|cellular carbohydrate metabolic process|metal ion binding" "hsa00030,hsa00040" Pentose phosphate pathway|Pentose and glucuronate interconversions RPF1 1120.904262 1102.838716 1138.969808 1.0327619 0.046507684 0.851904071 1 30.21379637 30.6815068 80135 ribosome production factor 1 homolog "GO:0000460,GO:0000470,GO:0003723,GO:0005515,GO:0005730,GO:0006364,GO:0019843,GO:0030687" "maturation of 5.8S rRNA|maturation of LSU-rRNA|RNA binding|protein binding|nucleolus|rRNA processing|rRNA binding|preribosome, large subunit precursor" RPF2 418.4916425 426.5696919 410.4135932 0.962125535 -0.05570295 0.853304531 1 5.137720707 4.860415662 84154 ribosome production factor 2 homolog "GO:0000027,GO:0000463,GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0008097,GO:0019843,GO:0042273,GO:1901796,GO:1902570" "ribosomal large subunit assembly|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|5S rRNA binding|rRNA binding|ribosomal large subunit biogenesis|regulation of signal transduction by p53 class mediator|protein localization to nucleolus" RPGR 341.1437402 364.1448589 318.1426214 0.873670501 -0.194838815 0.523743247 1 3.330547018 2.861109109 6103 retinitis pigmentosa GTPase regulator "GO:0001750,GO:0003723,GO:0005085,GO:0005515,GO:0005794,GO:0005813,GO:0006886,GO:0007601,GO:0036064,GO:0036126,GO:0042073,GO:0050790,GO:0050896,GO:0060271" photoreceptor outer segment|RNA binding|guanyl-nucleotide exchange factor activity|protein binding|Golgi apparatus|centrosome|intracellular protein transport|visual perception|ciliary basal body|sperm flagellum|intraciliary transport|regulation of catalytic activity|response to stimulus|cilium assembly RPGRIP1L 338.3741288 379.7510672 296.9971904 0.782083886 -0.354604736 0.242886289 1 1.346708519 1.035614503 23322 RPGRIP1 like "GO:0001701,GO:0001736,GO:0001822,GO:0001889,GO:0005515,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005879,GO:0005886,GO:0005911,GO:0005923,GO:0005929,GO:0005930,GO:0007163,GO:0007368,GO:0008589,GO:0021532,GO:0021549,GO:0021670,GO:0021772,GO:0022038,GO:0031870,GO:0032391,GO:0035115,GO:0035116,GO:0035253,GO:0035869,GO:0036064,GO:0043584,GO:0045744,GO:0046548,GO:0060039,GO:0090102,GO:0097711,GO:1905515" in utero embryonic development|establishment of planar polarity|kidney development|liver development|protein binding|nucleoplasm|cytoplasm|centrosome|cytosol|axonemal microtubule|plasma membrane|cell-cell junction|bicellular tight junction|cilium|axoneme|establishment or maintenance of cell polarity|determination of left/right symmetry|regulation of smoothened signaling pathway|neural tube patterning|cerebellum development|lateral ventricle development|olfactory bulb development|corpus callosum development|thromboxane A2 receptor binding|photoreceptor connecting cilium|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|ciliary rootlet|ciliary transition zone|ciliary basal body|nose development|negative regulation of G protein-coupled receptor signaling pathway|retinal rod cell development|pericardium development|cochlea development|ciliary basal body-plasma membrane docking|non-motile cilium assembly RPH3AL 41.55741905 31.21241648 51.90242162 1.662877389 0.733681797 0.257503835 1 0.612633064 1.001686542 9501 rabphilin 3A like (without C2 domains) "GO:0005515,GO:0005737,GO:0006886,GO:0006887,GO:0008092,GO:0017157,GO:0030274,GO:0030658,GO:0030667,GO:0042493,GO:0046872,GO:0050714" protein binding|cytoplasm|intracellular protein transport|exocytosis|cytoskeletal protein binding|regulation of exocytosis|LIM domain binding|transport vesicle membrane|secretory granule membrane|response to drug|metal ion binding|positive regulation of protein secretion RPIA 494.2342647 497.3178359 491.1506935 0.987599193 -0.018002437 0.955681152 1 14.63923821 14.21576982 22934 ribose 5-phosphate isomerase A "GO:0004751,GO:0005515,GO:0005829,GO:0006014,GO:0006098,GO:0009052,GO:0019693,GO:0042802,GO:0043231,GO:0048029" "ribose-5-phosphate isomerase activity|protein binding|cytosol|D-ribose metabolic process|pentose-phosphate shunt|pentose-phosphate shunt, non-oxidative branch|ribose phosphate metabolic process|identical protein binding|intracellular membrane-bounded organelle|monosaccharide binding" hsa00030 Pentose phosphate pathway RPL10 51119.14934 52009.24958 50229.0491 0.965771464 -0.050246259 0.878121691 1 1117.85665 1061.528509 6134 ribosomal protein L10 "GO:0000027,GO:0000122,GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005783,GO:0005790,GO:0005829,GO:0006412,GO:0006413,GO:0006417,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0032991,GO:0043066,GO:0045182,GO:1990403" "ribosomal large subunit assembly|negative regulation of transcription by RNA polymerase II|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|endoplasmic reticulum|smooth endoplasmic reticulum|cytosol|translation|translational initiation|regulation of translation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|protein-containing complex|negative regulation of apoptotic process|translation regulator activity|embryonic brain development" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL10A 12693.77471 12851.19228 12536.35713 0.975501484 -0.035784028 0.889694516 1 701.9902891 673.3334922 4736 ribosomal protein L10a "GO:0000184,GO:0000470,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0042788,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of LSU-rRNA|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleus|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL11 11837.68903 11698.4137 11976.96437 1.023810978 0.033949381 0.894580425 1 598.0103814 602.0044257 6135 ribosomal protein L11 "GO:0000027,GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006605,GO:0006614,GO:0008097,GO:0010628,GO:0016020,GO:0019083,GO:0022625,GO:0031625,GO:0032092,GO:0032435,GO:0032991,GO:0034504,GO:0042273,GO:0042788,GO:0050821,GO:0070062,GO:1901796,GO:1902255,GO:1904667,GO:1990948,GO:2000059,GO:2000435" "ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|translation|translational initiation|protein targeting|SRP-dependent cotranslational protein targeting to membrane|5S rRNA binding|positive regulation of gene expression|membrane|viral transcription|cytosolic large ribosomal subunit|ubiquitin protein ligase binding|positive regulation of protein binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein-containing complex|protein localization to nucleus|ribosomal large subunit biogenesis|polysomal ribosome|protein stabilization|extracellular exosome|regulation of signal transduction by p53 class mediator|positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator|negative regulation of ubiquitin protein ligase activity|ubiquitin ligase inhibitor activity|negative regulation of ubiquitin-dependent protein catabolic process|negative regulation of protein neddylation" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL12 22258.10576 23117.99647 21398.21505 0.925608544 -0.111525914 0.688052355 1 1946.00155 1771.094421 6136 ribosomal protein L12 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0015934,GO:0016020,GO:0019083,GO:0022625,GO:0070062,GO:0070180" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|large ribosomal subunit|membrane|viral transcription|cytosolic large ribosomal subunit|extracellular exosome|large ribosomal subunit rRNA binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL13 29498.98072 29363.60101 29634.36044 1.00922092 0.013242018 0.964054129 1 331.5872657 329.0449779 6137 ribosomal protein L13 "GO:0000184,GO:0001824,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005730,GO:0005783,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0022626,GO:0060348" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|blastocyst development|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleolus|endoplasmic reticulum|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|cytosolic ribosome|bone development" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL13A 38252.82568 38614.96125 37890.6901 0.981243768 -0.027316508 0.929343832 1 1844.950323 1780.052319 23521 ribosomal protein L13a "GO:0000184,GO:0003723,GO:0003729,GO:0003735,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005840,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0015934,GO:0016020,GO:0017148,GO:0019083,GO:0022625,GO:0071346,GO:0097452,GO:1901194,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|mRNA binding|structural constituent of ribosome|nucleus|nucleolus|cytoplasm|cytosol|ribosome|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|large ribosomal subunit|membrane|negative regulation of translation|viral transcription|cytosolic large ribosomal subunit|cellular response to interferon-gamma|GAIT complex|negative regulation of formation of translation preinitiation complex|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL14 11354.16649 11154.27724 11554.05575 1.035840826 0.050802326 0.841973879 1 84.73783279 86.30611253 9045 ribosomal protein L14 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0016020,GO:0019083,GO:0022625,GO:0042273,GO:0045296,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|membrane|viral transcription|cytosolic large ribosomal subunit|ribosomal large subunit biogenesis|cadherin binding|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL15 28441.0058 28525.02742 28356.98417 0.994108919 -0.008524167 0.97663565 1 257.5415812 251.7401616 6138 ribosomal protein L15 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005829,GO:0005840,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0031672,GO:0045296,GO:0045471" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleus|cytosol|ribosome|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|A band|cadherin binding|response to ethanol" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL17 118.8210331 104.0413883 133.6006779 1.284110873 0.360769773 0.418439298 1 5.258047038 6.63893121 6139 ribosomal protein L17 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0022625" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleus|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|cytosolic large ribosomal subunit" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL18 9035.664251 8852.881727 9218.446774 1.041293339 0.058376542 0.815012839 1 734.7776468 752.3158378 6141 ribosomal protein L18 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005730,GO:0005783,GO:0005791,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0042788" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleolus|endoplasmic reticulum|rough endoplasmic reticulum|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL18A 10766.37619 10963.8815 10568.87089 0.963971646 -0.052937383 0.834554219 1 922.9056856 874.7677427 6142 ribosomal protein L18a "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0042788" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL19 21109.4254 21475.18295 20743.66784 0.965936723 -0.049999412 0.856062511 1 1015.138215 964.1509487 6143 ribosomal protein L19 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005730,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0042788" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleolus|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL21 12117.91887 11964.75965 12271.07809 1.025601721 0.036470588 0.887045197 1 1128.157654 1137.678927 6144 ribosomal protein L21 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005783,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|endoplasmic reticulum|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL22 8929.753428 8911.144905 8948.36195 1.004176461 0.006012812 0.98122609 1 230.7479018 227.8342313 6146 ribosomal protein L22 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0008201,GO:0019083,GO:0022625,GO:0042802,GO:0045182,GO:0046632,GO:0070062,GO:0098793,GO:0098978,GO:0099577,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleus|cytoplasm|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|heparin binding|viral transcription|cytosolic large ribosomal subunit|identical protein binding|translation regulator activity|alpha-beta T cell differentiation|extracellular exosome|presynapse|glutamatergic synapse|regulation of translation at presynapse, modulating synaptic transmission|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL22L1 757.1683262 751.1788233 763.1578291 1.015946943 0.02282506 0.933769144 1 21.07730452 21.05509845 200916 ribosomal protein L22 like 1 "GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005840" cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|ribosome "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL23 11818.02827 12784.60579 10851.45074 0.848790406 -0.236519745 0.354576192 1 252.1400273 210.4328012 9349 ribosomal protein L23 "GO:0000122,GO:0000184,GO:0001223,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005840,GO:0005925,GO:0006412,GO:0006413,GO:0006610,GO:0006614,GO:0008284,GO:0010628,GO:0014069,GO:0016020,GO:0019083,GO:0022625,GO:0031625,GO:0032986,GO:0032991,GO:0050821,GO:0070062,GO:0070180,GO:0071157,GO:0071158,GO:0072717,GO:1901798,GO:1904667,GO:1990948,GO:2000059" "negative regulation of transcription by RNA polymerase II|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|transcription coactivator binding|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|ribosome|focal adhesion|translation|translational initiation|ribosomal protein import into nucleus|SRP-dependent cotranslational protein targeting to membrane|positive regulation of cell population proliferation|positive regulation of gene expression|postsynaptic density|membrane|viral transcription|cytosolic large ribosomal subunit|ubiquitin protein ligase binding|protein-DNA complex disassembly|protein-containing complex|protein stabilization|extracellular exosome|large ribosomal subunit rRNA binding|negative regulation of cell cycle arrest|positive regulation of cell cycle arrest|cellular response to actinomycin D|positive regulation of signal transduction by p53 class mediator|negative regulation of ubiquitin protein ligase activity|ubiquitin ligase inhibitor activity|negative regulation of ubiquitin-dependent protein catabolic process" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL23A 18255.20055 17877.43175 18632.96936 1.042262089 0.059718106 0.824796275 1 983.5934793 1008.007494 6147 ribosomal protein L23a "GO:0000027,GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0019843,GO:0022625,GO:0045296,GO:0070062,GO:1904841" "ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleolus|cytoplasm|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|rRNA binding|cytosolic large ribosomal subunit|cadherin binding|extracellular exosome|TORC2 complex binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL24 7300.768073 7187.179101 7414.357045 1.031608777 0.044895953 0.855118056 1 684.9402485 694.7665393 6152 ribosomal protein L24 "GO:0000027,GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0010458,GO:0016020,GO:0019083,GO:0021554,GO:0022625,GO:0031290,GO:0042788,GO:0045202,GO:0045296,GO:0060041,GO:0070062,GO:1902626" "ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|cytoplasm|endoplasmic reticulum|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|exit from mitosis|membrane|viral transcription|optic nerve development|cytosolic large ribosomal subunit|retinal ganglion cell axon guidance|polysomal ribosome|synapse|cadherin binding|retina development in camera-type eye|extracellular exosome|assembly of large subunit precursor of preribosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL26 20010.2567 21094.39147 18926.12193 0.897211088 -0.156480645 0.566830517 1 1245.319583 1098.617793 6154 ribosomal protein L26 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0006977,GO:0016020,GO:0019083,GO:0022625,GO:0022626,GO:0034644,GO:0042273,GO:0045727,GO:0048027,GO:0070062,GO:0071480,GO:1902164,GO:1902167,GO:1904803,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|membrane|viral transcription|cytosolic large ribosomal subunit|cytosolic ribosome|cellular response to UV|ribosomal large subunit biogenesis|positive regulation of translation|mRNA 5'-UTR binding|extracellular exosome|cellular response to gamma radiation|positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of translation involved in cellular response to UV|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL26L1 832.0296647 723.0876484 940.9716809 1.301324512 0.379980772 0.129283398 1 22.152617 28.34535025 51121 ribosomal protein L26 like 1 "GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0022625,GO:0042273,GO:0070062" cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|cytosolic large ribosomal subunit|ribosomal large subunit biogenesis|extracellular exosome "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL27 12105.88687 12405.89514 11805.87861 0.951634564 -0.071520423 0.780210872 1 1021.728121 956.0414736 6155 ribosomal protein L27 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005840,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0070062,GO:0098556,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|ribosome|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|extracellular exosome|cytoplasmic side of rough endoplasmic reticulum membrane|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL27A 20539.81892 20285.98988 20793.64795 1.025025058 0.035659178 0.89670802 1 238.7267907 240.6062036 6157 ribosomal protein L27a "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005783,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|endoplasmic reticulum|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL28 11731.25236 11869.04157 11593.46314 0.976781745 -0.033891856 0.894650927 1 117.4974837 112.8488867 6158 ribosomal protein L28 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0030425,GO:0036464,GO:0044297,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|dendrite|cytoplasmic ribonucleoprotein granule|cell body|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL29 13790.62933 14104.89101 13476.36766 0.955439333 -0.065763824 0.80038094 1 717.59019 674.1410727 6159 ribosomal protein L29 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0007566,GO:0008201,GO:0016020,GO:0019083,GO:0022625,GO:0045296" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|embryo implantation|heparin binding|membrane|viral transcription|cytosolic large ribosomal subunit|cadherin binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL3 41195.14609 42834.87996 39555.41221 0.923439315 -0.114910939 0.713116264 1 1763.903408 1601.601026 6122 ribosomal protein L3 "GO:0000027,GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0008097,GO:0019083,GO:0022625,GO:0032991,GO:0045202,GO:0070062,GO:0071353" "ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleolus|cytoplasm|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|5S rRNA binding|viral transcription|cytosolic large ribosomal subunit|protein-containing complex|synapse|extracellular exosome|cellular response to interleukin-4" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL30 14528.80974 14471.11669 14586.50279 1.007973545 0.011457774 0.965335771 1 1550.79699 1537.004934 6156 ribosomal protein L30 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0016020,GO:0019083,GO:0022625,GO:0031640,GO:0035368,GO:0042788,GO:0050829,GO:0061844,GO:0070062,GO:0097421,GO:1904571" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleus|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|membrane|viral transcription|cytosolic large ribosomal subunit|killing of cells of other organism|selenocysteine insertion sequence binding|polysomal ribosome|defense response to Gram-negative bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide|extracellular exosome|liver regeneration|positive regulation of selenocysteine incorporation" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL31 9988.327206 9853.759883 10122.89453 1.027312889 0.03887565 0.877385138 1 229.040529 231.3589227 6160 ribosomal protein L31 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0042788,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL32 16488.75922 16279.35602 16698.16242 1.025726227 0.036645717 0.890531603 1 374.643946 377.8516801 6161 ribosomal protein L32 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0042788" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL34 3221.844301 3256.495453 3187.19315 0.978718747 -0.03103376 0.897066144 1 139.1458584 133.9057944 6164 ribosomal protein L34 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005783,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0022625,GO:0045296,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|endoplasmic reticulum|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|cytosolic large ribosomal subunit|cadherin binding|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL35 10319.92662 9752.839736 10887.01351 1.116291645 0.158713999 0.528939384 1 1151.529053 1263.932125 11224 ribosomal protein L35 "GO:0000184,GO:0000463,GO:0003723,GO:0003729,GO:0003735,GO:0005730,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|mRNA binding|structural constituent of ribosome|nucleolus|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL35A 8449.694927 8218.229259 8681.160595 1.056329815 0.079060354 0.7498907 1 355.4228453 369.1612058 6165 ribosomal protein L35a "GO:0000049,GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0042273,GO:0070062" "tRNA binding|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|ribosomal large subunit biogenesis|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL36 4037.757612 3922.360338 4153.154886 1.058840731 0.082485598 0.729785433 1 344.8585869 359.040022 25873 ribosomal protein L36 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005730,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0042788" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|nucleolus|cytoplasm|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL36A 11.04826308 12.48496659 9.61155956 0.769850643 -0.377349516 0.799003187 1 0.875558109 0.662769676 6173 ribosomal protein L36a "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005783,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0022625,GO:0042788" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|endoplasmic reticulum|cytosol|ribosome|plasma membrane|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL36AL 2104.741233 1963.260997 2246.221469 1.144127792 0.194248201 0.411806581 1 154.9935371 174.3649956 6166 ribosomal protein L36a like "GO:0003735,GO:0005515,GO:0005634,GO:0005783,GO:0005829,GO:0005886,GO:0006412,GO:0022625" structural constituent of ribosome|protein binding|nucleus|endoplasmic reticulum|cytosol|plasma membrane|translation|cytosolic large ribosomal subunit "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL37 12345.50094 12590.04839 12100.95349 0.961152261 -0.0571631 0.823943186 1 88.72411769 83.85038479 6167 ribosomal protein L37 "GO:0000184,GO:0003723,GO:0003735,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0019843,GO:0022625,GO:0045202,GO:0046872" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|rRNA binding|cytosolic large ribosomal subunit|synapse|metal ion binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL37A 17314.75019 16881.75566 17747.74473 1.051297335 0.072170759 0.787480114 1 301.1190749 311.2683829 6168 ribosomal protein L37a "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0022625,GO:0046872,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|cytosolic large ribosomal subunit|metal ion binding|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL38 5364.149874 5221.837277 5506.462472 1.054506715 0.076568282 0.750992218 1 251.0629353 260.3173593 6169 ribosomal protein L38 "GO:0000184,GO:0001501,GO:0001503,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006417,GO:0006614,GO:0007605,GO:0014069,GO:0019083,GO:0022618,GO:0022625,GO:0033291,GO:0034463,GO:0042474,GO:0042788,GO:0048318" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|skeletal system development|ossification|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|cytosol|focal adhesion|translation|translational initiation|regulation of translation|SRP-dependent cotranslational protein targeting to membrane|sensory perception of sound|postsynaptic density|viral transcription|ribonucleoprotein complex assembly|cytosolic large ribosomal subunit|eukaryotic 80S initiation complex|90S preribosome assembly|middle ear morphogenesis|polysomal ribosome|axial mesoderm development" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL39 19188.16288 18373.70917 20002.6166 1.088654251 0.122545838 0.65177887 1 2514.284843 2691.383768 6170 ribosomal protein L39 "GO:0000184,GO:0002181,GO:0002227,GO:0003723,GO:0003735,GO:0005615,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0019731,GO:0022625,GO:0042788,GO:0050830,GO:0061844" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|innate immune response in mucosa|RNA binding|structural constituent of ribosome|extracellular space|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|antibacterial humoral response|cytosolic large ribosomal subunit|polysomal ribosome|defense response to Gram-positive bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL39L 224.7406882 222.6485709 226.8328056 1.018793001 0.026860953 0.952442117 1 16.29951306 16.32795374 116832 ribosomal protein L39 like "GO:0003735,GO:0005515,GO:0006412,GO:0007283,GO:0022625" structural constituent of ribosome|protein binding|translation|spermatogenesis|cytosolic large ribosomal subunit RPL4 33803.72104 35021.3717 32586.07038 0.930462423 -0.103980207 0.729223252 1 681.877505 623.8445434 6124 ribosomal protein L4 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005791,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0070062,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleolus|cytoplasm|rough endoplasmic reticulum|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|extracellular exosome|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL41 25649.19818 24673.41523 26624.98114 1.079095897 0.10982308 0.699350958 1 2347.192198 2490.461731 6171 ribosomal protein L41 "GO:0000184,GO:0002181,GO:0003723,GO:0003730,GO:0003735,GO:0005515,GO:0005783,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0022625,GO:0042788,GO:0048027" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|mRNA 3'-UTR binding|structural constituent of ribosome|protein binding|endoplasmic reticulum|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome|mRNA 5'-UTR binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL5 19647.89526 21207.79658 18087.99394 0.852893598 -0.229562324 0.399568902 1 1100.993313 923.3167501 6125 ribosomal protein L5 "GO:0000027,GO:0000184,GO:0003723,GO:0003730,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005783,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0008097,GO:0010628,GO:0016020,GO:0019083,GO:0022625,GO:0031625,GO:0032991,GO:0042273,GO:0045727,GO:0048027,GO:0050821,GO:0070062,GO:1901796,GO:1904667,GO:1990904,GO:1990948,GO:2000059,GO:2000435" "ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|mRNA 3'-UTR binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|5S rRNA binding|positive regulation of gene expression|membrane|viral transcription|cytosolic large ribosomal subunit|ubiquitin protein ligase binding|protein-containing complex|ribosomal large subunit biogenesis|positive regulation of translation|mRNA 5'-UTR binding|protein stabilization|extracellular exosome|regulation of signal transduction by p53 class mediator|negative regulation of ubiquitin protein ligase activity|ribonucleoprotein complex|ubiquitin ligase inhibitor activity|negative regulation of ubiquitin-dependent protein catabolic process|negative regulation of protein neddylation" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL6 18841.39548 21331.60584 16351.18512 0.766523873 -0.38359737 0.157013682 1 372.6443855 280.8610054 6128 ribosomal protein L6 "GO:0000027,GO:0000184,GO:0002181,GO:0003677,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005791,GO:0005829,GO:0005925,GO:0006355,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0016020,GO:0019083,GO:0022625,GO:0036464,GO:0042788,GO:0045296" "ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|DNA binding|RNA binding|structural constituent of ribosome|protein binding|nucleus|rough endoplasmic reticulum|cytosol|focal adhesion|regulation of transcription, DNA-templated|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|membrane|viral transcription|cytosolic large ribosomal subunit|cytoplasmic ribonucleoprotein granule|polysomal ribosome|cadherin binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL7 26536.477 27427.39077 25645.56322 0.935034741 -0.096908127 0.734768818 1 798.1185585 733.7807852 6129 ribosomal protein L7 "GO:0000184,GO:0000463,GO:0003677,GO:0003723,GO:0003729,GO:0003735,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0016020,GO:0019083,GO:0022625,GO:0042273,GO:0042802,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|DNA binding|RNA binding|mRNA binding|structural constituent of ribosome|protein binding|nucleus|nucleolus|cytoplasm|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|membrane|viral transcription|cytosolic large ribosomal subunit|ribosomal large subunit biogenesis|identical protein binding|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL7A 33571.71304 33850.90609 33292.52 0.983504545 -0.023996375 0.936320201 1 2036.708729 1969.592921 6130 ribosomal protein L7a "GO:0000184,GO:0000470,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0042788,GO:0045202,GO:0045296" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of LSU-rRNA|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleolus|cytoplasm|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome|synapse|cadherin binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL7L1 2803.243218 2902.754733 2703.731704 0.931436499 -0.102470679 0.665685726 1 40.66002232 37.23848836 285855 ribosomal protein L7 like 1 "GO:0000463,GO:0001825,GO:0003723,GO:0003735,GO:0005515,GO:0005730,GO:0022625" "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|blastocyst formation|RNA binding|structural constituent of ribosome|protein binding|nucleolus|cytosolic large ribosomal subunit" RPL8 33020.24695 31472.51995 34567.97396 1.098354184 0.135343352 0.650847878 1 1569.748174 1695.288335 6132 ribosomal protein L8 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0016020,GO:0019083,GO:0022625,GO:0042788,GO:0098794,GO:1990090,GO:1990932" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|membrane|viral transcription|cytosolic large ribosomal subunit|polysomal ribosome|postsynapse|cellular response to nerve growth factor stimulus|5.8S rRNA binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPL9 11038.26567 10758.91996 11317.61138 1.051928207 0.073036245 0.773620461 1 651.0020229 673.3480664 6133 ribosomal protein L9 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005829,GO:0005840,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0019843,GO:0022625" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleus|cytosol|ribosome|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|rRNA binding|cytosolic large ribosomal subunit" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPLP0 50672.34949 51369.39504 49975.30393 0.972861446 -0.039693743 0.903397621 1 2353.210472 2251.038609 6175 ribosomal protein lateral stalk subunit P0 "GO:0000027,GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0016020,GO:0019083,GO:0022625,GO:0030425,GO:0035722,GO:0036464,GO:0070062,GO:0070180,GO:0071353,GO:0098794,GO:1990904" "ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleus|cytoplasm|endoplasmic reticulum|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|membrane|viral transcription|cytosolic large ribosomal subunit|dendrite|interleukin-12-mediated signaling pathway|cytoplasmic ribonucleoprotein granule|extracellular exosome|large ribosomal subunit rRNA binding|cellular response to interleukin-4|postsynapse|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPLP1 15420.59155 15690.48176 15150.70133 0.965598225 -0.050505071 0.848150935 1 713.2642026 677.20174 6176 ribosomal protein lateral stalk subunit P1 "GO:0000184,GO:0002181,GO:0003735,GO:0005515,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006414,GO:0006614,GO:0019083,GO:0022625,GO:0030295,GO:0032147,GO:0043021" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|structural constituent of ribosome|protein binding|cytosol|focal adhesion|translation|translational initiation|translational elongation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|cytosolic large ribosomal subunit|protein kinase activator activity|activation of protein kinase activity|ribonucleoprotein complex binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPLP2 10088.98062 9922.427199 10255.53405 1.033571106 0.047637644 0.850077986 1 1146.194162 1164.849266 6181 ribosomal protein lateral stalk subunit P2 "GO:0000184,GO:0002182,GO:0003735,GO:0005515,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translational elongation|structural constituent of ribosome|protein binding|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPN1 6121.160299 5867.934298 6374.3863 1.086308397 0.119433734 0.622515157 1 137.1107131 146.4521341 6184 ribophorin I "GO:0003723,GO:0004579,GO:0005515,GO:0005783,GO:0005789,GO:0005791,GO:0005829,GO:0006464,GO:0006487,GO:0008250,GO:0016020,GO:0016021,GO:0018279,GO:0042470" RNA binding|dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|rough endoplasmic reticulum|cytosol|cellular protein modification process|protein N-linked glycosylation|oligosaccharyltransferase complex|membrane|integral component of membrane|protein N-linked glycosylation via asparagine|melanosome "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum RPN2 8461.025009 8326.432303 8595.617714 1.032329022 0.045902857 0.853398558 1 178.3171704 181.0016273 6185 ribophorin II "GO:0000421,GO:0004579,GO:0005515,GO:0005783,GO:0005789,GO:0005791,GO:0006464,GO:0006487,GO:0007568,GO:0008250,GO:0016020,GO:0016021,GO:0016604,GO:0018279,GO:0042493,GO:0043022" autophagosome membrane|dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|rough endoplasmic reticulum|cellular protein modification process|protein N-linked glycosylation|aging|oligosaccharyltransferase complex|membrane|integral component of membrane|nuclear body|protein N-linked glycosylation via asparagine|response to drug|ribosome binding "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum RPP25 9.487642252 9.363724944 9.61155956 1.026467524 0.037687984 1 1 0.212197363 0.214168885 54913 ribonuclease P and MRP subunit p25 "GO:0000172,GO:0001682,GO:0003723,GO:0004526,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0030681,GO:0033204,GO:0034451,GO:0090502" "ribonuclease MRP complex|tRNA 5'-leader removal|RNA binding|ribonuclease P activity|protein binding|nucleoplasm|nucleolus|rRNA processing|multimeric ribonuclease P complex|ribonuclease P RNA binding|centriolar satellite|RNA phosphodiester bond hydrolysis, endonucleolytic" "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport RPP25L 230.5025936 235.1335375 225.8716497 0.960610095 -0.057977126 0.87879152 1 11.66230924 11.01546608 138716 ribonuclease P/MRP subunit p25 like "GO:0000172,GO:0001682,GO:0003723,GO:0005515" ribonuclease MRP complex|tRNA 5'-leader removal|RNA binding|protein binding "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport RPP30 1716.069348 1676.106765 1756.031932 1.047685009 0.06720503 0.779052806 1 15.49198779 15.9591242 10556 ribonuclease P/MRP subunit p30 "GO:0000172,GO:0001682,GO:0003723,GO:0004526,GO:0005515,GO:0005634,GO:0005654,GO:0005655,GO:0006364,GO:0008033,GO:0030681,GO:0033204,GO:0090502" "ribonuclease MRP complex|tRNA 5'-leader removal|RNA binding|ribonuclease P activity|protein binding|nucleus|nucleoplasm|nucleolar ribonuclease P complex|rRNA processing|tRNA processing|multimeric ribonuclease P complex|ribonuclease P RNA binding|RNA phosphodiester bond hydrolysis, endonucleolytic" "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport RPP38 225.7465036 211.2040182 240.288989 1.13771031 0.186133258 0.599212394 1 6.810616479 7.618847789 10557 ribonuclease P/MRP subunit p38 "GO:0001650,GO:0001682,GO:0004526,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0030681,GO:0033204,GO:0090502" "fibrillar center|tRNA 5'-leader removal|ribonuclease P activity|protein binding|nucleoplasm|nucleolus|rRNA processing|multimeric ribonuclease P complex|ribonuclease P RNA binding|RNA phosphodiester bond hydrolysis, endonucleolytic" "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport RPP40 152.0450802 143.5771158 160.5130447 1.117957021 0.160864726 0.701876517 1 2.457487744 2.701392234 10799 ribonuclease P/MRP subunit p40 "GO:0000171,GO:0000172,GO:0000447,GO:0001682,GO:0004526,GO:0005634,GO:0005654,GO:0005655,GO:0030681,GO:0033204,GO:1905267" "ribonuclease MRP activity|ribonuclease MRP complex|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|tRNA 5'-leader removal|ribonuclease P activity|nucleus|nucleoplasm|nucleolar ribonuclease P complex|multimeric ribonuclease P complex|ribonuclease P RNA binding|endonucleolytic cleavage involved in tRNA processing" "hsa03008,hsa03013" Ribosome biogenesis in eukaryotes|RNA transport RPRD1A 1672.226697 1849.855883 1494.597512 0.807953487 -0.307655854 0.195355248 1 16.09183514 12.78389259 55197 regulation of nuclear pre-mRNA domain containing 1A "GO:0000993,GO:0005515,GO:0005654,GO:0016591,GO:0031124,GO:0042795,GO:0070940" "RNA polymerase II complex binding|protein binding|nucleoplasm|RNA polymerase II, holoenzyme|mRNA 3'-end processing|snRNA transcription by RNA polymerase II|dephosphorylation of RNA polymerase II C-terminal domain" RPRD1B 1585.759103 1560.620824 1610.897382 1.032215742 0.045744538 0.850047599 1 13.29833388 13.49705101 58490 regulation of nuclear pre-mRNA domain containing 1B "GO:0000993,GO:0005515,GO:0005634,GO:0005654,GO:0008284,GO:0010564,GO:0016591,GO:0031124,GO:0042795,GO:0042802,GO:0045944,GO:0070940" "RNA polymerase II complex binding|protein binding|nucleus|nucleoplasm|positive regulation of cell population proliferation|regulation of cell cycle process|RNA polymerase II, holoenzyme|mRNA 3'-end processing|snRNA transcription by RNA polymerase II|identical protein binding|positive regulation of transcription by RNA polymerase II|dephosphorylation of RNA polymerase II C-terminal domain" RPRD2 1030.198327 1194.395137 866.0015164 0.725054456 -0.463838741 0.058479259 1 8.264316514 5.891810177 23248 regulation of nuclear pre-mRNA domain containing 2 "GO:0000993,GO:0005654,GO:0016591,GO:0031124,GO:0042795" "RNA polymerase II complex binding|nucleoplasm|RNA polymerase II, holoenzyme|mRNA 3'-end processing|snRNA transcription by RNA polymerase II" RPS10 10.48842717 10.40413883 10.57271552 1.016202849 0.023188414 1 1 0.673846805 0.673306427 6204 ribosomal protein S10 "GO:0000028,GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0005840,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022627" "ribosomal small subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|nucleolus|cytosol|ribosome|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic small ribosomal subunit" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS11 15004.11081 14547.06691 15461.15471 1.062836571 0.087919775 0.73784685 1 1354.886954 1415.926562 6205 ribosomal protein S11 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005840,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0019843,GO:0022627,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|ribosome|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|rRNA binding|cytosolic small ribosomal subunit|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS12 7193.995473 7197.58324 7190.407707 0.999003064 -0.001438993 0.995955161 1 763.6616082 750.134183 6206 ribosomal protein S12 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005794,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022627,GO:0043231" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|Golgi apparatus|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic small ribosomal subunit|intracellular membrane-bounded organelle" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS13 7616.24868 7432.716778 7799.780583 1.049384877 0.069543904 0.777586219 1 752.69532 776.64973 6207 ribosomal protein S13 "GO:0000184,GO:0003723,GO:0003729,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005840,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0016020,GO:0019083,GO:0022627,GO:0033119,GO:0048027,GO:0070062,GO:0070181" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|mRNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|ribosome|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|membrane|viral transcription|cytosolic small ribosomal subunit|negative regulation of RNA splicing|mRNA 5'-UTR binding|extracellular exosome|small ribosomal subunit rRNA binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS14 15677.73279 15312.81152 16042.65406 1.047662216 0.067173643 0.799318129 1 345.8385981 356.2590637 6208 ribosomal protein S14 "GO:0000028,GO:0000122,GO:0000184,GO:0000462,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006417,GO:0006614,GO:0014069,GO:0016020,GO:0019083,GO:0022627,GO:0030218,GO:0030490,GO:0045182,GO:0048027,GO:0070062,GO:0070181" "ribosomal small subunit assembly|negative regulation of transcription by RNA polymerase II|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|nucleolus|cytosol|focal adhesion|rRNA processing|translation|translational initiation|regulation of translation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|membrane|viral transcription|cytosolic small ribosomal subunit|erythrocyte differentiation|maturation of SSU-rRNA|translation regulator activity|mRNA 5'-UTR binding|extracellular exosome|small ribosomal subunit rRNA binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS15 7258.324954 6968.692186 7547.957722 1.083123995 0.115198411 0.63841417 1 742.3279322 790.5787891 6209 ribosomal protein S15 "GO:0000028,GO:0000056,GO:0000184,GO:0001649,GO:0003677,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022627,GO:0042274" "ribosomal small subunit assembly|ribosomal small subunit export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|osteoblast differentiation|DNA binding|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic small ribosomal subunit|ribosomal small subunit biogenesis" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS15A 10524.26366 11016.9426 10031.58471 0.910559769 -0.135174376 0.592491727 1 266.8878704 238.9507913 6210 ribosomal protein S15a "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0008284,GO:0009615,GO:0016020,GO:0019083,GO:0022627,GO:0045787,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|cytoplasm|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|positive regulation of cell population proliferation|response to virus|membrane|viral transcription|cytosolic small ribosomal subunit|positive regulation of cell cycle|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS16 10212.62633 10178.36901 10246.88365 1.006731396 0.009678812 0.969760539 1 748.2105334 740.6424658 6217 ribosomal protein S16 "GO:0000184,GO:0000462,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0015935,GO:0016020,GO:0019083,GO:0022627,GO:0042274,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|small ribosomal subunit|membrane|viral transcription|cytosolic small ribosomal subunit|ribosomal small subunit biogenesis|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS17 14186.93022 15336.74104 13037.11939 0.850057998 -0.234366818 0.368853099 1 1677.241151 1401.894222 6218 ribosomal protein S17 "GO:0000184,GO:0003723,GO:0003735,GO:0005654,GO:0005829,GO:0005840,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022627,GO:0034101,GO:0042274" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|nucleoplasm|cytosol|ribosome|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic small ribosomal subunit|erythrocyte homeostasis|ribosomal small subunit biogenesis" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS18 22373.65771 23085.74364 21661.57178 0.938309466 -0.091864276 0.741084704 1 2244.15976 2070.480034 6222 ribosomal protein S18 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005840,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0015935,GO:0016020,GO:0019083,GO:0019843,GO:0022627,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|cytosol|ribosome|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|small ribosomal subunit|membrane|viral transcription|rRNA binding|cytosolic small ribosomal subunit|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS19 9672.160272 9224.309484 10120.01106 1.09710229 0.133698044 0.593705733 1 233.0892252 251.4435493 6223 ribosomal protein S19 "GO:0000028,GO:0000184,GO:0000462,GO:0002548,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005840,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0007000,GO:0009991,GO:0014069,GO:0016020,GO:0017134,GO:0019083,GO:0019901,GO:0022627,GO:0030218,GO:0030490,GO:0031640,GO:0042274,GO:0042802,GO:0050829,GO:0051272,GO:0060265,GO:0060266,GO:0061844,GO:0070062" "ribosomal small subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|monocyte chemotaxis|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|ribosome|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|nucleolus organization|response to extracellular stimulus|postsynaptic density|membrane|fibroblast growth factor binding|viral transcription|protein kinase binding|cytosolic small ribosomal subunit|erythrocyte differentiation|maturation of SSU-rRNA|killing of cells of other organism|ribosomal small subunit biogenesis|identical protein binding|defense response to Gram-negative bacterium|positive regulation of cellular component movement|positive regulation of respiratory burst involved in inflammatory response|negative regulation of respiratory burst involved in inflammatory response|antimicrobial humoral immune response mediated by antimicrobial peptide|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS19BP1 583.3588427 553.5001856 613.2174999 1.107890324 0.147815068 0.579484303 1 36.02352148 39.24226923 91582 ribosomal protein S19 binding protein 1 "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0019899" RNA binding|protein binding|nucleoplasm|nucleolus|cytosol|enzyme binding RPS2 37205.23427 38742.93216 35667.53637 0.920620469 -0.119321575 0.696661606 1 2187.977866 1980.590673 6187 ribosomal protein S2 "GO:0000184,GO:0003723,GO:0003729,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0017134,GO:0019083,GO:0019899,GO:0022627,GO:0045296,GO:0051443,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|mRNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|fibroblast growth factor binding|viral transcription|enzyme binding|cytosolic small ribosomal subunit|cadherin binding|positive regulation of ubiquitin-protein transferase activity|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS20 24593.67706 23609.07182 25578.2823 1.083409059 0.11557806 0.682287145 1 653.8519832 696.5352289 6224 ribosomal protein S20 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0015935,GO:0016020,GO:0019083,GO:0022627,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|small ribosomal subunit|membrane|viral transcription|cytosolic small ribosomal subunit|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS21 4364.394694 4309.394302 4419.395086 1.025525811 0.036363803 0.879848784 1 193.9160654 195.5381782 6227 ribosomal protein S21 "GO:0000184,GO:0000447,GO:0000461,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005791,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0015935,GO:0019083,GO:0022627,GO:0042788,GO:0047485" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|rough endoplasmic reticulum|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|small ribosomal subunit|viral transcription|cytosolic small ribosomal subunit|polysomal ribosome|protein N-terminus binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS23 16337.60046 16222.13326 16453.06765 1.01423576 0.020393047 0.938994982 1 266.2193841 265.4909807 6228 ribosomal protein S23 "GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005783,GO:0005791,GO:0005829,GO:0005840,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022627,GO:0034063,GO:0042788,GO:1990145" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|endoplasmic reticulum|rough endoplasmic reticulum|cytosol|ribosome|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic small ribosomal subunit|stress granule assembly|polysomal ribosome|maintenance of translational fidelity" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS24 23948.51835 25256.047 22640.9897 0.896458171 -0.157691827 0.574789881 1 476.1104945 419.6710031 6229 ribosomal protein S24 "GO:0000184,GO:0003723,GO:0003735,GO:0005634,GO:0005654,GO:0005783,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0015935,GO:0016020,GO:0019083,GO:0022627,GO:0031369,GO:0034101,GO:0042274" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|nucleus|nucleoplasm|endoplasmic reticulum|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|small ribosomal subunit|membrane|viral transcription|cytosolic small ribosomal subunit|translation initiation factor binding|erythrocyte homeostasis|ribosomal small subunit biogenesis" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS25 11107.59343 10648.63609 11566.55077 1.086200212 0.11929005 0.638495453 1 1176.600697 1256.637927 6230 ribosomal protein S25 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005840,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0014069,GO:0015935,GO:0019083,GO:0022627,GO:0042274,GO:0070062" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|ribosome|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|postsynaptic density|small ribosomal subunit|viral transcription|cytosolic small ribosomal subunit|ribosomal small subunit biogenesis|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS26 2580.383255 2186.949981 2973.816528 1.359800889 0.443395418 0.060922402 1 102.3802641 136.8871699 6231 ribosomal protein S26 "GO:0000184,GO:0002181,GO:0003723,GO:0003729,GO:0003735,GO:0005515,GO:0005654,GO:0005829,GO:0006412,GO:0006413,GO:0006614,GO:0015935,GO:0016020,GO:0019083,GO:0022627,GO:0033119,GO:0042788,GO:0045296,GO:0070062,GO:0098556" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|mRNA binding|structural constituent of ribosome|protein binding|nucleoplasm|cytosol|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|small ribosomal subunit|membrane|viral transcription|cytosolic small ribosomal subunit|negative regulation of RNA splicing|polysomal ribosome|cadherin binding|extracellular exosome|cytoplasmic side of rough endoplasmic reticulum membrane" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS27 10831.41715 11056.47833 10606.35597 0.959288813 -0.059962862 0.813033578 1 1247.492447 1176.680302 6232 ribosomal protein S27 "GO:0000028,GO:0000184,GO:0003677,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005840,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0008270,GO:0014069,GO:0019083,GO:0022627,GO:0098793,GO:0098978,GO:0098982" "ribosomal small subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|DNA binding|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|cytosol|ribosome|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|zinc ion binding|postsynaptic density|viral transcription|cytosolic small ribosomal subunit|presynapse|glutamatergic synapse|GABA-ergic synapse" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS27A 8369.389329 8141.238632 8597.540026 1.056048154 0.07867562 0.750893111 1 394.9844935 410.1426625 6233 ribosomal protein S27a "GO:0000122,GO:0000184,GO:0000187,GO:0000209,GO:0000715,GO:0000717,GO:0002755,GO:0002756,GO:0003723,GO:0003735,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005741,GO:0005789,GO:0005829,GO:0005886,GO:0006283,GO:0006294,GO:0006296,GO:0006297,GO:0006412,GO:0006413,GO:0006614,GO:0006625,GO:0007179,GO:0007249,GO:0007254,GO:0010008,GO:0015935,GO:0016020,GO:0016055,GO:0016197,GO:0016567,GO:0016579,GO:0019058,GO:0019068,GO:0019083,GO:0019221,GO:0019941,GO:0019985,GO:0022627,GO:0030512,GO:0030666,GO:0031145,GO:0031386,GO:0031625,GO:0031982,GO:0033683,GO:0035666,GO:0036297,GO:0042276,GO:0042769,GO:0043065,GO:0043066,GO:0043488,GO:0043657,GO:0044267,GO:0045944,GO:0046872,GO:0051092,GO:0051403,GO:0055085,GO:0061024,GO:0061418,GO:0070062,GO:0070423,GO:0070498,GO:0070911,GO:0070987,GO:0075733" "negative regulation of transcription by RNA polymerase II|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|activation of MAPK activity|protein polyubiquitination|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|RNA binding|structural constituent of ribosome|protein binding|extracellular space|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrial outer membrane|endoplasmic reticulum membrane|cytosol|plasma membrane|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|protein targeting to peroxisome|transforming growth factor beta receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|JNK cascade|endosome membrane|small ribosomal subunit|membrane|Wnt signaling pathway|endosomal transport|protein ubiquitination|protein deubiquitination|viral life cycle|virion assembly|viral transcription|cytokine-mediated signaling pathway|modification-dependent protein catabolic process|translesion synthesis|cytosolic small ribosomal subunit|negative regulation of transforming growth factor beta receptor signaling pathway|endocytic vesicle membrane|anaphase-promoting complex-dependent catabolic process|protein tag|ubiquitin protein ligase binding|vesicle|nucleotide-excision repair, DNA incision|TRIF-dependent toll-like receptor signaling pathway|interstrand cross-link repair|error-prone translesion synthesis|DNA damage response, detection of DNA damage|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of mRNA stability|host cell|cellular protein metabolic process|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|transmembrane transport|membrane organization|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|global genome nucleotide-excision repair|error-free translesion synthesis|intracellular transport of virus" "hsa03010,hsa04120,hsa04137,hsa05012,hsa05022,hsa05131,hsa05167,hsa05171" Ribosome|Ubiquitin mediated proteolysis|Mitophagy - animal|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Shigellosis|Kaposi sarcoma-associated herpesvirus infection|Coronavirus disease - COVID-19 RPS27L 736.1769949 666.9052988 805.4486911 1.207740728 0.272310777 0.284962518 1 5.825124399 6.917514769 51065 ribosomal protein S27 like "GO:0000028,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0006412,GO:0006919,GO:0006978,GO:0008494,GO:0008656,GO:0022627,GO:0031571,GO:0042771,GO:0045727,GO:0046872" "ribosomal small subunit assembly|RNA binding|structural constituent of ribosome|protein binding|nucleus|translation|activation of cysteine-type endopeptidase activity involved in apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|translation activator activity|cysteine-type endopeptidase activator activity involved in apoptotic process|cytosolic small ribosomal subunit|mitotic G1 DNA damage checkpoint|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of translation|metal ion binding" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS28 1448.641508 1443.054055 1454.228961 1.007743928 0.01112909 0.966061024 1 57.90461858 57.37656886 6234 ribosomal protein S28 "GO:0000028,GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0015935,GO:0019083,GO:0022627,GO:0030490,GO:0042254,GO:0042274,GO:0042788,GO:0070062,GO:0098556" "ribosomal small subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|small ribosomal subunit|viral transcription|cytosolic small ribosomal subunit|maturation of SSU-rRNA|ribosome biogenesis|ribosomal small subunit biogenesis|polysomal ribosome|extracellular exosome|cytoplasmic side of rough endoplasmic reticulum membrane" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS29 2265.554989 2210.879501 2320.230478 1.049460397 0.069647725 0.769677078 1 15.79102991 16.29474953 6235 ribosomal protein S29 "GO:0000184,GO:0002181,GO:0003735,GO:0005654,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0008270,GO:0015935,GO:0019083,GO:0022627,GO:0042788,GO:0070062,GO:0098556" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|structural constituent of ribosome|nucleoplasm|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|zinc ion binding|small ribosomal subunit|viral transcription|cytosolic small ribosomal subunit|polysomal ribosome|extracellular exosome|cytoplasmic side of rough endoplasmic reticulum membrane" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS3 37342.843 37939.73264 36745.95335 0.968534852 -0.04612413 0.880350687 1 746.0478264 710.4820354 6188 ribosomal protein S3 "GO:0000184,GO:0000977,GO:0003677,GO:0003684,GO:0003723,GO:0003729,GO:0003735,GO:0003906,GO:0004520,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005743,GO:0005759,GO:0005783,GO:0005829,GO:0005840,GO:0005844,GO:0005886,GO:0005925,GO:0006281,GO:0006412,GO:0006413,GO:0006614,GO:0006915,GO:0006974,GO:0007059,GO:0008017,GO:0008134,GO:0010628,GO:0014069,GO:0015631,GO:0016020,GO:0017148,GO:0019083,GO:0019104,GO:0019899,GO:0019900,GO:0019901,GO:0022627,GO:0030544,GO:0031116,GO:0031334,GO:0031397,GO:0032079,GO:0032357,GO:0032358,GO:0032587,GO:0032743,GO:0034614,GO:0042104,GO:0042769,GO:0042981,GO:0043507,GO:0044390,GO:0044877,GO:0045738,GO:0045739,GO:0050862,GO:0051018,GO:0051092,GO:0051225,GO:0051301,GO:0051536,GO:0051879,GO:0061481,GO:0070062,GO:0070181,GO:0070301,GO:0071159,GO:0071356,GO:0072686,GO:0097100,GO:0140078,GO:1901224,GO:1902231,GO:1902546,GO:1905053,GO:1990904,GO:2001235,GO:2001272" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding|damaged DNA binding|RNA binding|mRNA binding|structural constituent of ribosome|DNA-(apurinic or apyrimidinic site) endonuclease activity|endodeoxyribonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrial inner membrane|mitochondrial matrix|endoplasmic reticulum|cytosol|ribosome|polysome|plasma membrane|focal adhesion|DNA repair|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|apoptotic process|cellular response to DNA damage stimulus|chromosome segregation|microtubule binding|transcription factor binding|positive regulation of gene expression|postsynaptic density|tubulin binding|membrane|negative regulation of translation|viral transcription|DNA N-glycosylase activity|enzyme binding|kinase binding|protein kinase binding|cytosolic small ribosomal subunit|Hsp70 protein binding|positive regulation of microtubule polymerization|positive regulation of protein-containing complex assembly|negative regulation of protein ubiquitination|positive regulation of endodeoxyribonuclease activity|oxidized purine DNA binding|oxidized pyrimidine DNA binding|ruffle membrane|positive regulation of interleukin-2 production|cellular response to reactive oxygen species|positive regulation of activated T cell proliferation|DNA damage response, detection of DNA damage|regulation of apoptotic process|positive regulation of JUN kinase activity|ubiquitin-like protein conjugating enzyme binding|protein-containing complex binding|negative regulation of DNA repair|positive regulation of DNA repair|positive regulation of T cell receptor signaling pathway|protein kinase A binding|positive regulation of NF-kappaB transcription factor activity|spindle assembly|cell division|iron-sulfur cluster binding|Hsp90 protein binding|response to TNF agonist|extracellular exosome|small ribosomal subunit rRNA binding|cellular response to hydrogen peroxide|NF-kappaB complex|cellular response to tumor necrosis factor|mitotic spindle|supercoiled DNA binding|class I DNA-(apurinic or apyrimidinic site) endonuclease activity|positive regulation of NIK/NF-kappaB signaling|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of DNA N-glycosylase activity|positive regulation of base-excision repair|ribonucleoprotein complex|positive regulation of apoptotic signaling pathway|positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis" "hsa03010,hsa05130,hsa05132,hsa05171" Ribosome|Pathogenic Escherichia coli infection|Salmonella infection|Coronavirus disease - COVID-19 RPS3A 18215.59379 18074.06997 18357.1176 1.015660426 0.022418135 0.933894962 1 490.6306691 489.9755419 6189 ribosomal protein S3A "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005783,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0022627,GO:0030154,GO:0043066,GO:0048027,GO:0070062,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|cytosolic small ribosomal subunit|cell differentiation|negative regulation of apoptotic process|mRNA 5'-UTR binding|extracellular exosome|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS4X 51188.21222 51463.03229 50913.39214 0.989319709 -0.015491276 0.962343995 1 1863.288635 1812.541566 6191 ribosomal protein S4 X-linked "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005829,GO:0005840,GO:0005844,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0007275,GO:0008284,GO:0015935,GO:0016020,GO:0019083,GO:0019843,GO:0022627,GO:0036464,GO:0045202,GO:0045471,GO:0045727,GO:0070062,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|cytosol|ribosome|polysome|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|multicellular organism development|positive regulation of cell population proliferation|small ribosomal subunit|membrane|viral transcription|rRNA binding|cytosolic small ribosomal subunit|cytoplasmic ribonucleoprotein granule|synapse|response to ethanol|positive regulation of translation|extracellular exosome|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS5 9612.195622 9454.240952 9770.150293 1.033414564 0.047419121 0.850131249 1 680.9115566 691.8890568 6193 ribosomal protein S5 "GO:0000028,GO:0000184,GO:0003723,GO:0003729,GO:0003735,GO:0005515,GO:0005654,GO:0005829,GO:0005840,GO:0005925,GO:0006412,GO:0006413,GO:0006450,GO:0006614,GO:0016020,GO:0019083,GO:0019843,GO:0022627,GO:0070062,GO:1990904" "ribosomal small subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|mRNA binding|structural constituent of ribosome|protein binding|nucleoplasm|cytosol|ribosome|focal adhesion|translation|translational initiation|regulation of translational fidelity|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|rRNA binding|cytosolic small ribosomal subunit|extracellular exosome|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS6 21131.46659 21637.48752 20625.44566 0.953227386 -0.069107695 0.802002692 1 843.5010524 790.5936436 6194 ribosomal protein S6 "GO:0000082,GO:0000184,GO:0001890,GO:0002309,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005783,GO:0005829,GO:0005844,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0006924,GO:0007369,GO:0008284,GO:0015935,GO:0016020,GO:0019083,GO:0019901,GO:0022605,GO:0022627,GO:0030425,GO:0031929,GO:0033077,GO:0036464,GO:0042274,GO:0042593,GO:0043065,GO:0043066,GO:0044297,GO:0048471,GO:0048821,GO:1990904" "G1/S transition of mitotic cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|placenta development|T cell proliferation involved in immune response|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|nucleolus|endoplasmic reticulum|cytosol|polysome|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|activation-induced cell death of T cells|gastrulation|positive regulation of cell population proliferation|small ribosomal subunit|membrane|viral transcription|protein kinase binding|mammalian oogenesis stage|cytosolic small ribosomal subunit|dendrite|TOR signaling|T cell differentiation in thymus|cytoplasmic ribonucleoprotein granule|ribosomal small subunit biogenesis|glucose homeostasis|positive regulation of apoptotic process|negative regulation of apoptotic process|cell body|perinuclear region of cytoplasm|erythrocyte development|ribonucleoprotein complex" "hsa01521,hsa03010,hsa04066,hsa04150,hsa04151,hsa04371,hsa04714,hsa04910,hsa05171,hsa05205" EGFR tyrosine kinase inhibitor resistance|Ribosome|HIF-1 signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Thermogenesis|Insulin signaling pathway|Coronavirus disease - COVID-19|Proteoglycans in cancer RPS6KA1 1261.138068 1239.132934 1283.143201 1.035516986 0.050351219 0.83761055 1 17.81526058 18.13930256 6195 ribosomal protein S6 kinase A1 "GO:0000287,GO:0004674,GO:0004711,GO:0004712,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0007049,GO:0007165,GO:0018105,GO:0030307,GO:0035556,GO:0043027,GO:0043066,GO:0043154,GO:0043555,GO:0043620,GO:0045597,GO:0045893,GO:0045944,GO:0072574,GO:0106310,GO:0106311,GO:2000491" "magnesium ion binding|protein serine/threonine kinase activity|ribosomal protein S6 kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|cytosol|apoptotic process|cell cycle|signal transduction|peptidyl-serine phosphorylation|positive regulation of cell growth|intracellular signal transduction|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of translation in response to stress|regulation of DNA-templated transcription in response to stress|positive regulation of cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|hepatocyte proliferation|protein serine kinase activity|protein threonine kinase activity|positive regulation of hepatic stellate cell activation" "hsa04010,hsa04114,hsa04150,hsa04714,hsa04720,hsa04722,hsa04914,hsa04931,hsa05135" MAPK signaling pathway|Oocyte meiosis|mTOR signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Progesterone-mediated oocyte maturation|Insulin resistance|Yersinia infection RPS6KA2 357.7306117 446.3375557 269.1236677 0.602959944 -0.72986593 0.014492557 0.708244576 3.660706164 2.170323692 6196 ribosomal protein S6 kinase A2 "GO:0000287,GO:0004674,GO:0004711,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0008285,GO:0018105,GO:0035556,GO:0043065,GO:0045786,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|ribosomal protein S6 kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|signal transduction|negative regulation of cell population proliferation|peptidyl-serine phosphorylation|intracellular signal transduction|positive regulation of apoptotic process|negative regulation of cell cycle|protein serine kinase activity|protein threonine kinase activity "hsa04010,hsa04114,hsa04150,hsa04714,hsa04720,hsa04722,hsa04914,hsa04931,hsa05135" MAPK signaling pathway|Oocyte meiosis|mTOR signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Progesterone-mediated oocyte maturation|Insulin resistance|Yersinia infection RPS6KA3 3452.825015 3895.309577 3010.340454 0.772811607 -0.371811332 0.117248922 1 25.43875585 19.33039293 6197 ribosomal protein S6 kinase A3 "GO:0000287,GO:0001501,GO:0002224,GO:0004672,GO:0004674,GO:0004711,GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006915,GO:0007049,GO:0007165,GO:0007417,GO:0018105,GO:0019901,GO:0030307,GO:0032496,GO:0035556,GO:0043027,GO:0043066,GO:0043154,GO:0043555,GO:0043620,GO:0045597,GO:0045944,GO:0106310,GO:0106311" magnesium ion binding|skeletal system development|toll-like receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|ribosomal protein S6 kinase activity|protein binding|ATP binding|nucleoplasm|nucleolus|cytoplasm|cytosol|apoptotic process|cell cycle|signal transduction|central nervous system development|peptidyl-serine phosphorylation|protein kinase binding|positive regulation of cell growth|response to lipopolysaccharide|intracellular signal transduction|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of translation in response to stress|regulation of DNA-templated transcription in response to stress|positive regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|protein serine kinase activity|protein threonine kinase activity "hsa04010,hsa04114,hsa04150,hsa04714,hsa04720,hsa04722,hsa04914,hsa04931,hsa05135" MAPK signaling pathway|Oocyte meiosis|mTOR signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Progesterone-mediated oocyte maturation|Insulin resistance|Yersinia infection RPS6KA4 1179.217129 1195.435551 1162.998707 0.972866087 -0.03968686 0.873325145 1 20.39584343 19.51038829 8986 ribosomal protein S6 kinase A4 "GO:0000287,GO:0001818,GO:0004674,GO:0004711,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006468,GO:0006954,GO:0016572,GO:0018105,GO:0032793,GO:0033129,GO:0035066,GO:0035556,GO:0043987,GO:0043988,GO:0045944,GO:0051092,GO:0070498,GO:0106310,GO:0106311" "magnesium ion binding|negative regulation of cytokine production|protein serine/threonine kinase activity|ribosomal protein S6 kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|protein phosphorylation|inflammatory response|histone phosphorylation|peptidyl-serine phosphorylation|positive regulation of CREB transcription factor activity|positive regulation of histone phosphorylation|positive regulation of histone acetylation|intracellular signal transduction|histone H3-S10 phosphorylation|histone H3-S28 phosphorylation|positive regulation of transcription by RNA polymerase II|positive regulation of NF-kappaB transcription factor activity|interleukin-1-mediated signaling pathway|protein serine kinase activity|protein threonine kinase activity" "hsa04010,hsa04668" MAPK signaling pathway|TNF signaling pathway RPS6KA5 403.5295586 387.0339643 420.0251528 1.085241068 0.118015548 0.688491243 1 0.74358454 0.793464955 9252 ribosomal protein S6 kinase A5 "GO:0000287,GO:0001818,GO:0002223,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006468,GO:0006954,GO:0007173,GO:0007411,GO:0016572,GO:0018105,GO:0032793,GO:0033129,GO:0035066,GO:0035556,GO:0043987,GO:0043988,GO:0043990,GO:0045892,GO:0045944,GO:0051092,GO:0070498,GO:0106310,GO:0106311" "magnesium ion binding|negative regulation of cytokine production|stimulatory C-type lectin receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|protein phosphorylation|inflammatory response|epidermal growth factor receptor signaling pathway|axon guidance|histone phosphorylation|peptidyl-serine phosphorylation|positive regulation of CREB transcription factor activity|positive regulation of histone phosphorylation|positive regulation of histone acetylation|intracellular signal transduction|histone H3-S10 phosphorylation|histone H3-S28 phosphorylation|histone H2A-S1 phosphorylation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of NF-kappaB transcription factor activity|interleukin-1-mediated signaling pathway|protein serine kinase activity|protein threonine kinase activity" "hsa04010,hsa04261,hsa04668,hsa04713,hsa04722,hsa05131,hsa05200,hsa05206,hsa05219" MAPK signaling pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Circadian entrainment|Neurotrophin signaling pathway|Shigellosis|Pathways in cancer|MicroRNAs in cancer|Bladder cancer RPS6KA6 658.4227421 619.0462602 697.7992241 1.127216606 0.17276477 0.506589745 1 3.571220533 3.958177141 27330 ribosomal protein S6 kinase A6 "GO:0000287,GO:0001650,GO:0004672,GO:0004674,GO:0004711,GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0006978,GO:0007165,GO:0007417,GO:0018105,GO:0045992,GO:0070373,GO:0106310,GO:0106311,GO:2000381" "magnesium ion binding|fibrillar center|protein kinase activity|protein serine/threonine kinase activity|ribosomal protein S6 kinase activity|protein binding|ATP binding|nucleoplasm|nucleolus|cytoplasm|mitochondrion|cytosol|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|signal transduction|central nervous system development|peptidyl-serine phosphorylation|negative regulation of embryonic development|negative regulation of ERK1 and ERK2 cascade|protein serine kinase activity|protein threonine kinase activity|negative regulation of mesoderm development" "hsa04010,hsa04114,hsa04150,hsa04714,hsa04720,hsa04722,hsa04914,hsa04931,hsa05135" MAPK signaling pathway|Oocyte meiosis|mTOR signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Progesterone-mediated oocyte maturation|Insulin resistance|Yersinia infection RPS6KB1 1081.689982 1120.525752 1042.854212 0.93068295 -0.103638317 0.673592133 1 10.08608533 9.229869795 6198 ribosomal protein S6 kinase B1 "GO:0000082,GO:0001662,GO:0003009,GO:0004672,GO:0004674,GO:0004711,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005829,GO:0006915,GO:0007165,GO:0007281,GO:0007568,GO:0007584,GO:0007616,GO:0009408,GO:0009611,GO:0009612,GO:0009636,GO:0009749,GO:0009986,GO:0014732,GO:0014878,GO:0014911,GO:0016301,GO:0016477,GO:0018105,GO:0030165,GO:0031667,GO:0031929,GO:0032496,GO:0032869,GO:0033574,GO:0033762,GO:0034612,GO:0042277,GO:0042493,GO:0042802,GO:0043005,GO:0043066,GO:0043201,GO:0043491,GO:0044539,GO:0045202,GO:0045471,GO:0045727,GO:0045931,GO:0045948,GO:0046324,GO:0046627,GO:0048015,GO:0048471,GO:0048633,GO:0048661,GO:0051721,GO:0071346,GO:0071363,GO:0071549,GO:0106310,GO:0106311,GO:2001237" G1/S transition of mitotic cell cycle|behavioral fear response|skeletal muscle contraction|protein kinase activity|protein serine/threonine kinase activity|ribosomal protein S6 kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|cytosol|apoptotic process|signal transduction|germ cell development|aging|response to nutrient|long-term memory|response to heat|response to wounding|response to mechanical stimulus|response to toxic substance|response to glucose|cell surface|skeletal muscle atrophy|response to electrical stimulus involved in regulation of muscle adaptation|positive regulation of smooth muscle cell migration|kinase activity|cell migration|peptidyl-serine phosphorylation|PDZ domain binding|response to nutrient levels|TOR signaling|response to lipopolysaccharide|cellular response to insulin stimulus|response to testosterone|response to glucagon|response to tumor necrosis factor|peptide binding|response to drug|identical protein binding|neuron projection|negative regulation of apoptotic process|response to leucine|protein kinase B signaling|long-chain fatty acid import into cell|synapse|response to ethanol|positive regulation of translation|positive regulation of mitotic cell cycle|positive regulation of translational initiation|regulation of glucose import|negative regulation of insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|positive regulation of skeletal muscle tissue growth|positive regulation of smooth muscle cell proliferation|protein phosphatase 2A binding|cellular response to interferon-gamma|cellular response to growth factor stimulus|cellular response to dexamethasone stimulus|protein serine kinase activity|protein threonine kinase activity|negative regulation of extrinsic apoptotic signaling pathway "hsa01521,hsa01522,hsa04012,hsa04066,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04350,hsa04371,hsa04666,hsa04714,hsa04910,hsa04931,hsa05131,hsa05163,hsa05165,hsa05170,hsa05200,hsa05205,hsa05210,hsa05212,hsa05221,hsa05224,hsa05225,hsa05226,hsa05231,hsa05235" EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|HIF-1 signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|TGF-beta signaling pathway|Apelin signaling pathway|Fc gamma R-mediated phagocytosis|Thermogenesis|Insulin signaling pathway|Insulin resistance|Shigellosis|Human cytomegalovirus infection|Human papillomavirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Pancreatic cancer|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer RPS6KB2 835.7151583 819.8461395 851.584177 1.038712188 0.054795959 0.831070237 1 23.04038002 23.53184851 6199 ribosomal protein S6 kinase B2 "GO:0004672,GO:0004674,GO:0004711,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006412,GO:0007165,GO:0018105,GO:0031929,GO:0042277,GO:0043491,GO:0045948,GO:0106310,GO:0106311" protein kinase activity|protein serine/threonine kinase activity|ribosomal protein S6 kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|translation|signal transduction|peptidyl-serine phosphorylation|TOR signaling|peptide binding|protein kinase B signaling|positive regulation of translational initiation|protein serine kinase activity|protein threonine kinase activity "hsa01521,hsa01522,hsa04012,hsa04066,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04350,hsa04371,hsa04666,hsa04714,hsa04910,hsa04931,hsa05131,hsa05163,hsa05165,hsa05170,hsa05200,hsa05205,hsa05210,hsa05212,hsa05221,hsa05224,hsa05225,hsa05226,hsa05231,hsa05235" EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|HIF-1 signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|TGF-beta signaling pathway|Apelin signaling pathway|Fc gamma R-mediated phagocytosis|Thermogenesis|Insulin signaling pathway|Insulin resistance|Shigellosis|Human cytomegalovirus infection|Human papillomavirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Pancreatic cancer|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer RPS6KC1 932.196861 905.1600779 959.2336441 1.05973923 0.083709305 0.738423736 1 9.995185132 10.41504217 26750 ribosomal protein S6 kinase C1 "GO:0004674,GO:0005515,GO:0005524,GO:0005764,GO:0005768,GO:0005769,GO:0006468,GO:0007165,GO:0016020,GO:0035091,GO:0106310,GO:0106311" protein serine/threonine kinase activity|protein binding|ATP binding|lysosome|endosome|early endosome|protein phosphorylation|signal transduction|membrane|phosphatidylinositol binding|protein serine kinase activity|protein threonine kinase activity RPS6KL1 70.12917186 87.39476614 52.86357758 0.604882648 -0.725272819 0.171903247 1 0.851112782 0.506208482 83694 ribosomal protein S6 kinase like 1 "GO:0005524,GO:0005840,GO:0006468,GO:0106310,GO:0106311" ATP binding|ribosome|protein phosphorylation|protein serine kinase activity|protein threonine kinase activity RPS7 9235.406167 9693.536145 8777.27619 0.905477223 -0.143249744 0.56601375 1 706.7297924 629.219406 6201 ribosomal protein S7 "GO:0000184,GO:0001843,GO:0003723,GO:0003730,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005813,GO:0005829,GO:0005840,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0008266,GO:0010628,GO:0016020,GO:0019083,GO:0019901,GO:0022627,GO:0030154,GO:0032040,GO:0032991,GO:0042274,GO:0045202,GO:0048027,GO:0050821,GO:1902255,GO:1904667,GO:1990904,GO:1990948,GO:2000059" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|neural tube closure|RNA binding|mRNA 3'-UTR binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|nucleolus|centrosome|cytosol|ribosome|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|poly(U) RNA binding|positive regulation of gene expression|membrane|viral transcription|protein kinase binding|cytosolic small ribosomal subunit|cell differentiation|small-subunit processome|protein-containing complex|ribosomal small subunit biogenesis|synapse|mRNA 5'-UTR binding|protein stabilization|positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator|negative regulation of ubiquitin protein ligase activity|ribonucleoprotein complex|ubiquitin ligase inhibitor activity|negative regulation of ubiquitin-dependent protein catabolic process" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS8 21929.69225 22368.89848 21490.48602 0.960730634 -0.057796104 0.83486344 1 1534.430591 1449.506161 6202 ribosomal protein S8 "GO:0000184,GO:0000462,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005783,GO:0005829,GO:0005925,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022627,GO:0070062,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|endoplasmic reticulum|cytosol|focal adhesion|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic small ribosomal subunit|extracellular exosome|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPS9 10378.95097 10166.92446 10590.97748 1.041709075 0.058952423 0.815417898 1 532.4730839 545.400191 6203 ribosomal protein S9 "GO:0000184,GO:0003723,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005840,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0008284,GO:0015935,GO:0016020,GO:0019083,GO:0019843,GO:0022627,GO:0045182,GO:0045202,GO:0045903,GO:0070062,GO:1990904" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|ribosome|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|positive regulation of cell population proliferation|small ribosomal subunit|membrane|viral transcription|rRNA binding|cytosolic small ribosomal subunit|translation regulator activity|synapse|positive regulation of translational fidelity|extracellular exosome|ribonucleoprotein complex" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPSA 31950.57595 31235.30558 32665.84632 1.045798839 0.064605374 0.827948278 1 1462.255132 1503.635215 3921 ribosomal protein SA "GO:0000028,GO:0000184,GO:0001618,GO:0002181,GO:0003723,GO:0003735,GO:0005055,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006614,GO:0007155,GO:0016020,GO:0019083,GO:0022627,GO:0043022,GO:0043236,GO:0046718,GO:0070062" "ribosomal small subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|virus receptor activity|cytoplasmic translation|RNA binding|structural constituent of ribosome|laminin receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|cell adhesion|membrane|viral transcription|cytosolic small ribosomal subunit|ribosome binding|laminin binding|viral entry into host cell|extracellular exosome" "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RPSAP58 716.3443501 688.7539903 743.9347099 1.080116733 0.111187239 0.666797984 1 16.33668204 17.35024969 388524 ribosomal protein SA pseudogene 58 RPTOR 950.1311172 1022.726847 877.5353878 0.858034959 -0.220891666 0.37187445 1 7.982019905 6.734245856 57521 regulatory associated protein of MTOR complex 1 "GO:0001002,GO:0001003,GO:0001006,GO:0001156,GO:0001558,GO:0001938,GO:0005515,GO:0005654,GO:0005737,GO:0005764,GO:0005765,GO:0005829,GO:0007050,GO:0008361,GO:0009267,GO:0010494,GO:0010506,GO:0010800,GO:0016032,GO:0016241,GO:0019901,GO:0030291,GO:0030295,GO:0030307,GO:0030425,GO:0030674,GO:0031669,GO:0031929,GO:0031931,GO:0032008,GO:0032147,GO:0033138,GO:0038202,GO:0043025,GO:0044877,GO:0045945,GO:0071230,GO:0071233,GO:0071889,GO:0071901,GO:0071902,GO:1900034,GO:1900087" RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 3 promoter sequence-specific DNA binding|TFIIIC-class transcription factor complex binding|regulation of cell growth|positive regulation of endothelial cell proliferation|protein binding|nucleoplasm|cytoplasm|lysosome|lysosomal membrane|cytosol|cell cycle arrest|regulation of cell size|cellular response to starvation|cytoplasmic stress granule|regulation of autophagy|positive regulation of peptidyl-threonine phosphorylation|viral process|regulation of macroautophagy|protein kinase binding|protein serine/threonine kinase inhibitor activity|protein kinase activator activity|positive regulation of cell growth|dendrite|protein-macromolecule adaptor activity|cellular response to nutrient levels|TOR signaling|TORC1 complex|positive regulation of TOR signaling|activation of protein kinase activity|positive regulation of peptidyl-serine phosphorylation|TORC1 signaling|neuronal cell body|protein-containing complex binding|positive regulation of transcription by RNA polymerase III|cellular response to amino acid stimulus|cellular response to leucine|14-3-3 protein binding|negative regulation of protein serine/threonine kinase activity|positive regulation of protein serine/threonine kinase activity|regulation of cellular response to heat|positive regulation of G1/S transition of mitotic cell cycle "hsa04136,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04714,hsa04910,hsa05131,hsa05206" Autophagy - other|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Thermogenesis|Insulin signaling pathway|Shigellosis|MicroRNAs in cancer RPUSD1 476.0616203 474.4287305 477.6945101 1.006883604 0.009896917 0.980029502 1 9.874956858 9.776550649 113000 RNA pseudouridine synthase domain containing 1 "GO:0000455,GO:0003674,GO:0003723,GO:0005515,GO:0005575,GO:0008150,GO:0009982" enzyme-directed rRNA pseudouridine synthesis|molecular_function|RNA binding|protein binding|cellular_component|biological_process|pseudouridine synthase activity RPUSD2 156.6873137 151.9004269 161.4742006 1.063026641 0.088177754 0.839986873 1 3.715236756 3.883307863 27079 RNA pseudouridine synthase domain containing 2 "GO:0000455,GO:0003723,GO:0005575,GO:0008150,GO:0009982" enzyme-directed rRNA pseudouridine synthesis|RNA binding|cellular_component|biological_process|pseudouridine synthase activity RPUSD3 616.13188 619.0462602 613.2174999 0.99058429 -0.013648354 0.965250731 1 21.64964689 21.08693366 285367 RNA pseudouridine synthase D3 "GO:0000455,GO:0003723,GO:0005515,GO:0005759,GO:0006397,GO:0009982,GO:0070131" enzyme-directed rRNA pseudouridine synthesis|RNA binding|protein binding|mitochondrial matrix|mRNA processing|pseudouridine synthase activity|positive regulation of mitochondrial translation RPUSD4 551.602296 350.6194785 752.5851135 2.146444108 1.101948606 4.53E-05 0.019975 7.463868031 15.75268957 84881 RNA pseudouridine synthase D4 "GO:0000455,GO:0003723,GO:0005515,GO:0005654,GO:0005739,GO:0005759,GO:0008033,GO:0009982,GO:0070131" enzyme-directed rRNA pseudouridine synthesis|RNA binding|protein binding|nucleoplasm|mitochondrion|mitochondrial matrix|tRNA processing|pseudouridine synthase activity|positive regulation of mitochondrial translation RRAD 14.80859856 22.88910542 6.728091692 0.293942973 -1.766391806 0.073055442 1 0.831551728 0.240338602 6236 "RRAD, Ras related glycolysis inhibitor and calcium channel regulator" "GO:0003924,GO:0005246,GO:0005515,GO:0005516,GO:0005525,GO:0005886,GO:0007264,GO:1901842" GTPase activity|calcium channel regulator activity|protein binding|calmodulin binding|GTP binding|plasma membrane|small GTPase mediated signal transduction|negative regulation of high voltage-gated calcium channel activity RRAGA 1556.172089 1439.932814 1672.411363 1.16145097 0.215928253 0.365201192 1 48.05914182 54.88429263 10670 Ras related GTP binding A "GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005764,GO:0005765,GO:0005829,GO:0006915,GO:0007050,GO:0008219,GO:0009267,GO:0010506,GO:0010507,GO:0016241,GO:0016567,GO:0019048,GO:0031625,GO:0032008,GO:0034198,GO:0034448,GO:0034613,GO:0042803,GO:0046982,GO:0051219,GO:0071230,GO:1904263,GO:1990130,GO:1990131" GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|lysosome|lysosomal membrane|cytosol|apoptotic process|cell cycle arrest|cell death|cellular response to starvation|regulation of autophagy|negative regulation of autophagy|regulation of macroautophagy|protein ubiquitination|modulation by virus of host process|ubiquitin protein ligase binding|positive regulation of TOR signaling|cellular response to amino acid starvation|EGO complex|cellular protein localization|protein homodimerization activity|protein heterodimerization activity|phosphoprotein binding|cellular response to amino acid stimulus|positive regulation of TORC1 signaling|GATOR1 complex|Gtr1-Gtr2 GTPase complex "hsa04140,hsa04150,hsa05131" Autophagy - animal|mTOR signaling pathway|Shigellosis RRAGB 256.2355379 279.8713344 232.5997414 0.831095267 -0.266914235 0.424912987 1 6.320871239 5.165340208 10325 Ras related GTP binding B "GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005764,GO:0005765,GO:0005829,GO:0007050,GO:0009267,GO:0010506,GO:0016241,GO:0032006,GO:0032008,GO:0032561,GO:0034198,GO:0034448,GO:0034613,GO:0051020,GO:0071230,GO:1904263,GO:1990131,GO:1990253" GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|lysosome|lysosomal membrane|cytosol|cell cycle arrest|cellular response to starvation|regulation of autophagy|regulation of macroautophagy|regulation of TOR signaling|positive regulation of TOR signaling|guanyl ribonucleotide binding|cellular response to amino acid starvation|EGO complex|cellular protein localization|GTPase binding|cellular response to amino acid stimulus|positive regulation of TORC1 signaling|Gtr1-Gtr2 GTPase complex|cellular response to leucine starvation "hsa04140,hsa04150,hsa05131" Autophagy - animal|mTOR signaling pathway|Shigellosis RRAGC 1390.130496 1345.25515 1435.005842 1.066716483 0.09317678 0.699391442 1 26.77873737 28.08731859 64121 Ras related GTP binding C "GO:0000287,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005829,GO:0006351,GO:0006915,GO:0007050,GO:0007264,GO:0008380,GO:0009267,GO:0010506,GO:0016241,GO:0019003,GO:0032006,GO:0032008,GO:0034198,GO:0034448,GO:0034613,GO:0043200,GO:0043231,GO:0046982,GO:0051020,GO:0071230,GO:1903432,GO:1990131" "magnesium ion binding|GTPase activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|lysosome|cytosol|transcription, DNA-templated|apoptotic process|cell cycle arrest|small GTPase mediated signal transduction|RNA splicing|cellular response to starvation|regulation of autophagy|regulation of macroautophagy|GDP binding|regulation of TOR signaling|positive regulation of TOR signaling|cellular response to amino acid starvation|EGO complex|cellular protein localization|response to amino acid|intracellular membrane-bounded organelle|protein heterodimerization activity|GTPase binding|cellular response to amino acid stimulus|regulation of TORC1 signaling|Gtr1-Gtr2 GTPase complex" "hsa04140,hsa04150,hsa05131" Autophagy - animal|mTOR signaling pathway|Shigellosis RRAGD 857.5839715 813.6036562 901.5642867 1.108112383 0.148104205 0.555125452 1 6.966233241 7.590196129 58528 Ras related GTP binding D "GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005813,GO:0005829,GO:0007050,GO:0009267,GO:0010506,GO:0016241,GO:0019003,GO:0032008,GO:0034448,GO:0034613,GO:0043231,GO:0046982,GO:0051020,GO:0071230,GO:0071233,GO:1904263,GO:1990131,GO:1990253" GTPase activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|lysosome|centrosome|cytosol|cell cycle arrest|cellular response to starvation|regulation of autophagy|regulation of macroautophagy|GDP binding|positive regulation of TOR signaling|EGO complex|cellular protein localization|intracellular membrane-bounded organelle|protein heterodimerization activity|GTPase binding|cellular response to amino acid stimulus|cellular response to leucine|positive regulation of TORC1 signaling|Gtr1-Gtr2 GTPase complex|cellular response to leucine starvation "hsa04140,hsa04150,hsa05131" Autophagy - animal|mTOR signaling pathway|Shigellosis RRAS 1761.353733 1502.357647 2020.349819 1.344786193 0.427376817 0.071743692 1 81.31649734 107.5234234 6237 RAS related "GO:0002521,GO:0003924,GO:0005515,GO:0005525,GO:0005886,GO:0005925,GO:0007265,GO:0010595,GO:0019003,GO:0030336,GO:0044877,GO:0045766,GO:0051896,GO:0060325,GO:0070062,GO:0070372,GO:1904906,GO:2001214" leukocyte differentiation|GTPase activity|protein binding|GTP binding|plasma membrane|focal adhesion|Ras protein signal transduction|positive regulation of endothelial cell migration|GDP binding|negative regulation of cell migration|protein-containing complex binding|positive regulation of angiogenesis|regulation of protein kinase B signaling|face morphogenesis|extracellular exosome|regulation of ERK1 and ERK2 cascade|positive regulation of endothelial cell-matrix adhesion via fibronectin|positive regulation of vasculogenesis "hsa04010,hsa04014,hsa04015,hsa04024,hsa04072,hsa04137,hsa04140,hsa04218,hsa04360,hsa04371,hsa04625,hsa04810,hsa05132,hsa05205" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Phospholipase D signaling pathway|Mitophagy - animal|Autophagy - animal|Cellular senescence|Axon guidance|Apelin signaling pathway|C-type lectin receptor signaling pathway|Regulation of actin cytoskeleton|Salmonella infection|Proteoglycans in cancer RRAS2 2578.22194 2382.547791 2773.896089 1.164256222 0.219408592 0.353569166 1 44.80345197 51.28982559 22800 RAS related 2 "GO:0000139,GO:0001649,GO:0003924,GO:0005515,GO:0005525,GO:0005783,GO:0005886,GO:0005925,GO:0007265,GO:0016020,GO:0019003,GO:0030335,GO:0070062,GO:1901214" Golgi membrane|osteoblast differentiation|GTPase activity|protein binding|GTP binding|endoplasmic reticulum|plasma membrane|focal adhesion|Ras protein signal transduction|membrane|GDP binding|positive regulation of cell migration|extracellular exosome|regulation of neuron death "hsa04010,hsa04014,hsa04024,hsa04072,hsa04137,hsa04140,hsa04218,hsa04371,hsa04625,hsa04810,hsa05205" MAPK signaling pathway|Ras signaling pathway|cAMP signaling pathway|Phospholipase D signaling pathway|Mitophagy - animal|Autophagy - animal|Cellular senescence|Apelin signaling pathway|C-type lectin receptor signaling pathway|Regulation of actin cytoskeleton|Proteoglycans in cancer RRBP1 3961.610482 3563.417548 4359.803416 1.223489349 0.291001542 0.221692199 1 37.66548728 45.31218052 6238 ribosome binding protein 1 "GO:0001649,GO:0003723,GO:0005783,GO:0005840,GO:0006412,GO:0015031,GO:0016020,GO:0030176,GO:0038023" osteoblast differentiation|RNA binding|endoplasmic reticulum|ribosome|translation|protein transport|membrane|integral component of endoplasmic reticulum membrane|signaling receptor activity hsa04141 Protein processing in endoplasmic reticulum RREB1 579.1072541 668.9861265 489.2283816 0.731298247 -0.451468191 0.087979827 1 4.126986479 2.967554864 6239 ras responsive element binding protein 1 "GO:0000122,GO:0000977,GO:0000978,GO:0001228,GO:0001650,GO:0005634,GO:0005737,GO:0006355,GO:0006357,GO:0006366,GO:0007265,GO:0007275,GO:0010634,GO:0016604,GO:0016607,GO:0033601,GO:0045893,GO:0045944,GO:0046872,GO:0070062,GO:0090336,GO:1900026,GO:1903691,GO:2000394" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|fibrillar center|nucleus|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|Ras protein signal transduction|multicellular organism development|positive regulation of epithelial cell migration|nuclear body|nuclear speck|positive regulation of mammary gland epithelial cell proliferation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|extracellular exosome|positive regulation of brown fat cell differentiation|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of wound healing, spreading of epidermal cells|positive regulation of lamellipodium morphogenesis" RRM1 5922.502227 5219.756449 6625.248005 1.269263819 0.343991967 0.155387004 1 78.86999099 98.43167381 6240 ribonucleotide reductase catalytic subunit M1 "GO:0000278,GO:0004748,GO:0005515,GO:0005524,GO:0005635,GO:0005829,GO:0005971,GO:0006206,GO:0006260,GO:0008584,GO:0009263,GO:0010212,GO:0015949,GO:0021846,GO:0042802,GO:0042995,GO:0043025,GO:0051290,GO:0055114,GO:0060041,GO:0061731,GO:0097718" "mitotic cell cycle|ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor|protein binding|ATP binding|nuclear envelope|cytosol|ribonucleoside-diphosphate reductase complex|pyrimidine nucleobase metabolic process|DNA replication|male gonad development|deoxyribonucleotide biosynthetic process|response to ionizing radiation|nucleobase-containing small molecule interconversion|cell proliferation in forebrain|identical protein binding|cell projection|neuronal cell body|protein heterotetramerization|oxidation-reduction process|retina development in camera-type eye|ribonucleoside-diphosphate reductase activity|disordered domain specific binding" "hsa00230,hsa00240,hsa00480,hsa00983" Purine metabolism|Pyrimidine metabolism|Glutathione metabolism|Drug metabolism - other enzymes RRM2 6231.001263 5597.426689 6864.575838 1.22638066 0.294406851 0.225206856 1 87.117053 105.0508685 6241 ribonucleotide reductase regulatory subunit M2 "GO:0000083,GO:0004748,GO:0005515,GO:0005829,GO:0006260,GO:0009263,GO:0015949,GO:0046872,GO:0055114,GO:0070317" "regulation of transcription involved in G1/S transition of mitotic cell cycle|ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor|protein binding|cytosol|DNA replication|deoxyribonucleotide biosynthetic process|nucleobase-containing small molecule interconversion|metal ion binding|oxidation-reduction process|negative regulation of G0 to G1 transition" "hsa00230,hsa00240,hsa00480,hsa00983,hsa04115" Purine metabolism|Pyrimidine metabolism|Glutathione metabolism|Drug metabolism - other enzymes|p53 signaling pathway RRM2B 966.4361699 1009.201466 923.6708737 0.915249239 -0.127763426 0.606576163 1 10.6799975 9.611290549 50484 ribonucleotide reductase regulatory TP53 inducible subunit M2B "GO:0004748,GO:0005515,GO:0005654,GO:0005829,GO:0006260,GO:0006281,GO:0009263,GO:0015949,GO:0042802,GO:0046872,GO:0055114" "ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor|protein binding|nucleoplasm|cytosol|DNA replication|DNA repair|deoxyribonucleotide biosynthetic process|nucleobase-containing small molecule interconversion|identical protein binding|metal ion binding|oxidation-reduction process" "hsa00230,hsa00240,hsa00480,hsa00983,hsa04115" Purine metabolism|Pyrimidine metabolism|Glutathione metabolism|Drug metabolism - other enzymes|p53 signaling pathway RRN3 1081.383011 1087.232507 1075.533515 0.989239659 -0.015608016 0.953132407 1 15.61033109 15.18395165 54700 "RRN3 homolog, RNA polymerase I transcription factor" "GO:0001042,GO:0001164,GO:0001181,GO:0001188,GO:0005634,GO:0005654,GO:0005730,GO:0006361,GO:0010976" RNA polymerase I core binding|RNA polymerase I core promoter sequence-specific DNA binding|RNA polymerase I general transcription initiation factor activity|RNA polymerase I preinitiation complex assembly|nucleus|nucleoplasm|nucleolus|transcription initiation from RNA polymerase I promoter|positive regulation of neuron projection development RRNAD1 474.1047098 460.90335 487.3060697 1.057284721 0.080363939 0.777908995 1 9.349131389 9.719286806 51093 ribosomal RNA adenine dimethylase domain containing 1 "GO:0000179,GO:0016021,GO:0031167" "rRNA (adenine-N6,N6-)-dimethyltransferase activity|integral component of membrane|rRNA methylation" RRP1 511.0098346 508.7623886 513.2572805 1.008834953 0.012690167 0.970820036 1 8.567912154 8.498970161 8568 ribosomal RNA processing 1 "GO:0003723,GO:0005515,GO:0005634,GO:0005694,GO:0005730,GO:0006364,GO:0030687,GO:0030688" "RNA binding|protein binding|nucleus|chromosome|nucleolus|rRNA processing|preribosome, large subunit precursor|preribosome, small subunit precursor" RRP12 1537.452856 1680.26842 1394.637292 0.830008631 -0.268801755 0.259545543 1 18.91832013 15.43961112 23223 ribosomal RNA processing 12 homolog "GO:0003723,GO:0005730,GO:0005829,GO:0005886,GO:0006364,GO:0016021,GO:0031965,GO:0043231" RNA binding|nucleolus|cytosol|plasma membrane|rRNA processing|integral component of membrane|nuclear membrane|intracellular membrane-bounded organelle RRP15 470.5720873 481.7116277 459.432547 0.95375017 -0.068316685 0.812124483 1 3.108968947 2.915561397 51018 ribosomal RNA processing 15 homolog "GO:0000460,GO:0000470,GO:0030687" "maturation of 5.8S rRNA|maturation of LSU-rRNA|preribosome, large subunit precursor" RRP1B 1502.480104 1607.439449 1397.52076 0.869408027 -0.201894679 0.397993959 1 16.89367645 14.44172253 23076 ribosomal RNA processing 1B "GO:0001652,GO:0003713,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005829,GO:0006364,GO:0006397,GO:0006915,GO:0008380,GO:0010923,GO:0016032,GO:0030687,GO:0030688,GO:0034260,GO:0043065,GO:0043484,GO:0043923,GO:0045944,GO:0098586" "granular component|transcription coactivator activity|RNA binding|protein binding|nucleus|nucleoplasm|chromosome|nucleolus|cytosol|rRNA processing|mRNA processing|apoptotic process|RNA splicing|negative regulation of phosphatase activity|viral process|preribosome, large subunit precursor|preribosome, small subunit precursor|negative regulation of GTPase activity|positive regulation of apoptotic process|regulation of RNA splicing|positive regulation by host of viral transcription|positive regulation of transcription by RNA polymerase II|cellular response to virus" RRP36 671.0813158 610.7229491 731.4396825 1.197662023 0.26022084 0.313790374 1 27.55127754 32.44495669 88745 ribosomal RNA processing 36 "GO:0000462,GO:0000469,GO:0003723,GO:0005654,GO:0005730,GO:0006364,GO:0030686,GO:0042274" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cleavage involved in rRNA processing|RNA binding|nucleoplasm|nucleolus|rRNA processing|90S preribosome|ribosomal small subunit biogenesis" RRP7A 1112.611133 1011.282294 1213.939972 1.200396744 0.26351131 0.279684153 1 9.959453288 11.75523962 27341 ribosomal RNA processing 7 homolog A "GO:0000028,GO:0001825,GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0006364,GO:0032545,GO:0034456" ribosomal small subunit assembly|blastocyst formation|RNA binding|protein binding|nucleoplasm|cytoplasm|rRNA processing|CURI complex|UTP-C complex hsa03008 Ribosome biogenesis in eukaryotes RRP8 399.1250988 384.9531366 413.2970611 1.073629546 0.102496279 0.729787652 1 1.855848364 1.959151953 23378 ribosomal RNA processing 8 "GO:0000183,GO:0003723,GO:0005515,GO:0005654,GO:0005677,GO:0005730,GO:0005829,GO:0005886,GO:0006364,GO:0008757,GO:0032259,GO:0033553,GO:0035064,GO:0042149,GO:0046015,GO:0071158,GO:0072332" rDNA heterochromatin assembly|RNA binding|protein binding|nucleoplasm|chromatin silencing complex|nucleolus|cytosol|plasma membrane|rRNA processing|S-adenosylmethionine-dependent methyltransferase activity|methylation|rDNA heterochromatin|methylated histone binding|cellular response to glucose starvation|regulation of transcription by glucose|positive regulation of cell cycle arrest|intrinsic apoptotic signaling pathway by p53 class mediator RRP9 357.4286712 400.5593448 314.2979976 0.784647772 -0.34988292 0.24160097 1 13.86323997 10.69573577 9136 "ribosomal RNA processing 9, U3 small nucleolar RNA binding protein" "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0030515,GO:0031428,GO:0032040,GO:0034511" RNA binding|protein binding|nucleoplasm|nucleolus|rRNA processing|snoRNA binding|box C/D RNP complex|small-subunit processome|U3 snoRNA binding RRS1 658.2189525 727.249304 589.188601 0.810160419 -0.303720492 0.240595604 1 22.56509228 17.97543108 23212 ribosome biogenesis regulator 1 homolog "GO:0000027,GO:0000055,GO:0000447,GO:0000794,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0007080,GO:0008097,GO:0030687,GO:0042273,GO:1901796,GO:1902570" "ribosomal large subunit assembly|ribosomal large subunit export from nucleus|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|condensed nuclear chromosome|RNA binding|protein binding|nucleoplasm|nucleolus|mitotic metaphase plate congression|5S rRNA binding|preribosome, large subunit precursor|ribosomal large subunit biogenesis|regulation of signal transduction by p53 class mediator|protein localization to nucleolus" RSAD1 705.4489581 793.8357925 617.0621237 0.777317084 -0.36342487 0.155470701 1 17.17290524 13.12541867 55316 radical S-adenosyl methionine domain containing 1 "GO:0004109,GO:0005575,GO:0005737,GO:0005739,GO:0006779,GO:0008150,GO:0020037,GO:0046872,GO:0051539,GO:0055114" "coproporphyrinogen oxidase activity|cellular_component|cytoplasm|mitochondrion|porphyrin-containing compound biosynthetic process|biological_process|heme binding|metal ion binding|4 iron, 4 sulfur cluster binding|oxidation-reduction process" RSBN1 616.399222 651.2990905 581.4993534 0.892829979 -0.163542625 0.534590062 1 2.148379716 1.886040378 54665 round spermatid basic protein 1 "GO:0005634,GO:0006325,GO:0046872,GO:0051213,GO:0055114" nucleus|chromatin organization|metal ion binding|dioxygenase activity|oxidation-reduction process RSBN1L 540.2603102 570.1468077 510.3738126 0.895162098 -0.159779142 0.555153201 1 4.749873125 4.180756498 222194 round spermatid basic protein 1 like "GO:0005634,GO:0046872,GO:0051213,GO:0055114" nucleus|metal ion binding|dioxygenase activity|oxidation-reduction process RSC1A1 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.071768604 0.065191864 6248 regulator of solute carriers 1 "GO:0005515,GO:0005654,GO:0005794,GO:0005886,GO:0006355,GO:0010829,GO:0019871,GO:0030054,GO:0032243,GO:0042997,GO:0045920,GO:0051051,GO:1903077" "protein binding|nucleoplasm|Golgi apparatus|plasma membrane|regulation of transcription, DNA-templated|negative regulation of glucose transmembrane transport|sodium channel inhibitor activity|cell junction|negative regulation of nucleoside transport|negative regulation of Golgi to plasma membrane protein transport|negative regulation of exocytosis|negative regulation of transport|negative regulation of protein localization to plasma membrane" RSF1 1720.888991 1840.492158 1601.285823 0.87003132 -0.200860757 0.397866991 1 8.67470492 7.420971717 51773 remodeling and spacing factor 1 "GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0006334,GO:0006338,GO:0006352,GO:0016584,GO:0016887,GO:0031213,GO:0034080,GO:0042393,GO:0043392,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0050434" "transcription coregulator activity|protein binding|nucleus|nucleoplasm|nucleosome assembly|chromatin remodeling|DNA-templated transcription, initiation|nucleosome positioning|ATPase activity|RSF complex|CENP-A containing nucleosome assembly|histone binding|negative regulation of DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of viral transcription" RSKR 126.0592709 130.0517353 122.0668064 0.938601904 -0.091414708 0.849409853 1 1.84003767 1.698162802 124923 ribosomal protein S6 kinase related "GO:0005515,GO:0005524,GO:0006468,GO:0106310,GO:0106311" protein binding|ATP binding|protein phosphorylation|protein serine kinase activity|protein threonine kinase activity RSL1D1 2748.694488 3009.917362 2487.471614 0.826425219 -0.275043816 0.244899496 1 29.52826427 23.99455273 26156 ribosomal L1 domain containing 1 "GO:0000470,GO:0001649,GO:0003723,GO:0003730,GO:0005694,GO:0005730,GO:0016020,GO:0030686,GO:0032880,GO:0042981,GO:0045296,GO:0048027,GO:2000772" maturation of LSU-rRNA|osteoblast differentiation|RNA binding|mRNA 3'-UTR binding|chromosome|nucleolus|membrane|90S preribosome|regulation of protein localization|regulation of apoptotic process|cadherin binding|mRNA 5'-UTR binding|regulation of cellular senescence RSL24D1 1923.06325 1912.280716 1933.845783 1.011277145 0.016178429 0.947878852 1 54.02589053 53.72090312 51187 ribosomal L24 domain containing 1 "GO:0000027,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005730,GO:0006412,GO:0022625,GO:1902626" ribosomal large subunit assembly|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|nucleolus|translation|cytosolic large ribosomal subunit|assembly of large subunit precursor of preribosome "hsa03010,hsa05171" Ribosome|Coronavirus disease - COVID-19 RSPH3 295.9153044 299.6391982 292.1914106 0.975144148 -0.036312598 0.919639209 1 2.601039898 2.493945803 83861 radial spoke head 3 "GO:0005515,GO:0005737,GO:0005856,GO:0005929" protein binding|cytoplasm|cytoskeleton|cilium RSPH4A 4.082397604 6.242483296 1.922311912 0.307940257 -1.699277611 0.406294648 1 0.051997793 0.015744271 345895 radial spoke head component 4A "GO:0001534,GO:0003341,GO:0003674,GO:0005654,GO:0005730,GO:0005930,GO:0031514,GO:0035082,GO:0060294,GO:0062177" radial spoke|cilium movement|molecular_function|nucleoplasm|nucleolus|axoneme|motile cilium|axoneme assembly|cilium movement involved in cell motility|radial spoke assembly RSPO2 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.043630426 340419 R-spondin 2 "GO:0001649,GO:0005102,GO:0005515,GO:0005576,GO:0008201,GO:0009986,GO:0016055,GO:0030177,GO:0030282,GO:0035115,GO:0035116,GO:0042489,GO:0060173,GO:0060437,GO:0060441,GO:0060535,GO:0071542,GO:0090263" osteoblast differentiation|signaling receptor binding|protein binding|extracellular region|heparin binding|cell surface|Wnt signaling pathway|positive regulation of Wnt signaling pathway|bone mineralization|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|negative regulation of odontogenesis of dentin-containing tooth|limb development|lung growth|epithelial tube branching involved in lung morphogenesis|trachea cartilage morphogenesis|dopaminergic neuron differentiation|positive regulation of canonical Wnt signaling pathway hsa04310 Wnt signaling pathway RSPO3 8.967435311 8.323311061 9.61155956 1.154775965 0.207612985 0.965671908 1 0.148017265 0.168066552 84870 R-spondin 3 "GO:0001974,GO:0002040,GO:0005102,GO:0005109,GO:0005576,GO:0008201,GO:0016055,GO:0030111,GO:0030177,GO:0060670,GO:0090263,GO:2000052,GO:2000096" "blood vessel remodeling|sprouting angiogenesis|signaling receptor binding|frizzled binding|extracellular region|heparin binding|Wnt signaling pathway|regulation of Wnt signaling pathway|positive regulation of Wnt signaling pathway|branching involved in labyrinthine layer morphogenesis|positive regulation of canonical Wnt signaling pathway|positive regulation of non-canonical Wnt signaling pathway|positive regulation of Wnt signaling pathway, planar cell polarity pathway" hsa04310 Wnt signaling pathway RSPRY1 1156.000931 1166.303962 1145.6979 0.982332168 -0.025717152 0.919331011 1 14.88366784 14.37604798 89970 ring finger and SPRY domain containing 1 "GO:0004842,GO:0005576,GO:0005737,GO:0016567,GO:0046872,GO:0051603" ubiquitin-protein transferase activity|extracellular region|cytoplasm|protein ubiquitination|metal ion binding|proteolysis involved in cellular protein catabolic process RSRC1 433.8751683 414.0847253 453.6656112 1.095586443 0.131703319 0.646806398 1 8.428276405 9.079388465 51319 arginine and serine rich coiled-coil 1 "GO:0000380,GO:0000398,GO:0005515,GO:0005634,GO:0005737,GO:0006468,GO:0006913,GO:0008380,GO:0016607,GO:0046677" "alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|protein binding|nucleus|cytoplasm|protein phosphorylation|nucleocytoplasmic transport|RNA splicing|nuclear speck|response to antibiotic" RSRC2 1294.129986 1159.021065 1429.238907 1.233143167 0.302340305 0.209282165 1 16.29473764 19.75750277 65117 arginine and serine rich coiled-coil 2 "GO:0003723,GO:0005515" RNA binding|protein binding RSRP1 417.238607 355.8215479 478.6556661 1.345212703 0.427834307 0.134680233 1 6.743445326 8.919571249 57035 arginine and serine rich protein 1 GO:0005515 protein binding RSU1 1406.386474 1254.739142 1558.033805 1.241719296 0.312339074 0.192200129 1 17.82356186 21.76151397 6251 Ras suppressor protein 1 "GO:0005515,GO:0005829,GO:0005925,GO:0007165,GO:0010810,GO:0010811,GO:0043547,GO:0070062" protein binding|cytosol|focal adhesion|signal transduction|regulation of cell-substrate adhesion|positive regulation of cell-substrate adhesion|positive regulation of GTPase activity|extracellular exosome RTBDN 80.74654676 75.95021343 85.54288008 1.126302037 0.171593762 0.753195988 1 2.462529344 2.727140182 83546 retbindin "GO:0031362,GO:0032217,GO:0032218,GO:0033165,GO:0038023,GO:1902444" anchored component of external side of plasma membrane|riboflavin transmembrane transporter activity|riboflavin transport|interphotoreceptor matrix|signaling receptor activity|riboflavin binding RTCA 949.9090491 878.109317 1021.708781 1.16353256 0.218511583 0.377220327 1 17.53857797 20.06522793 8634 RNA 3'-terminal phosphate cyclase "GO:0003723,GO:0003963,GO:0005524,GO:0005634,GO:0005654,GO:0006396" RNA binding|RNA-3'-phosphate cyclase activity|ATP binding|nucleus|nucleoplasm|RNA processing RTCB 2252.986349 2095.39356 2410.579138 1.15041832 0.202158555 0.392746263 1 55.38747058 62.65251366 51493 "RNA 2',3'-cyclic phosphate and 5'-OH ligase" "GO:0000971,GO:0003723,GO:0003972,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006388,GO:0017166,GO:0043231,GO:0046872,GO:0072669" "tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate|RNA binding|RNA ligase (ATP) activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|cytosol|tRNA splicing, via endonucleolytic cleavage and ligation|vinculin binding|intracellular membrane-bounded organelle|metal ion binding|tRNA-splicing ligase complex" RTEL1 1120.59226 1082.030438 1159.154083 1.07127678 0.099331269 0.685672284 1 11.50547435 12.11929617 51750 regulator of telomere elongation helicase 1 "GO:0000723,GO:0000732,GO:0000781,GO:0003677,GO:0003678,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006281,GO:0010569,GO:0031297,GO:0032206,GO:0032508,GO:0043247,GO:0045910,GO:0046872,GO:0051539,GO:0070182,GO:0090657,GO:1902990,GO:1904355,GO:1904358,GO:1904430,GO:1904506,GO:1904535" "telomere maintenance|strand displacement|chromosome, telomeric region|DNA binding|DNA helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|DNA repair|regulation of double-strand break repair via homologous recombination|replication fork processing|positive regulation of telomere maintenance|DNA duplex unwinding|telomere maintenance in response to DNA damage|negative regulation of DNA recombination|metal ion binding|4 iron, 4 sulfur cluster binding|DNA polymerase binding|telomeric loop disassembly|mitotic telomere maintenance via semi-conservative replication|positive regulation of telomere capping|positive regulation of telomere maintenance via telomere lengthening|negative regulation of t-circle formation|negative regulation of telomere maintenance in response to DNA damage|positive regulation of telomeric loop disassembly" RTF1 1601.326297 1489.87268 1712.779914 1.149614955 0.201150734 0.398473919 1 15.83584279 17.90048364 23168 "RTF1 homolog, Paf1/RNA polymerase II complex component" "GO:0000122,GO:0001711,GO:0001832,GO:0003697,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006366,GO:0006368,GO:0016055,GO:0016567,GO:0016593,GO:0019827,GO:0051571,GO:0080182,GO:1990269" negative regulation of transcription by RNA polymerase II|endodermal cell fate commitment|blastocyst growth|single-stranded DNA binding|RNA binding|protein binding|nucleoplasm|nucleolus|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|Wnt signaling pathway|protein ubiquitination|Cdc73/Paf1 complex|stem cell population maintenance|positive regulation of histone H3-K4 methylation|histone H3-K4 trimethylation|RNA polymerase II C-terminal domain phosphoserine binding RTF2 1963.680249 1792.63312 2134.727378 1.190833392 0.251971581 0.2872271 1 50.08876172 58.64925205 51507 replication termination factor 2 "GO:0003677,GO:0005515,GO:0005634,GO:0005657,GO:0071171,GO:0072711,GO:0097752,GO:1902979" DNA binding|protein binding|nucleus|replication fork|site-specific DNA replication termination at RTS1 barrier|cellular response to hydroxyurea|regulation of DNA stability|mitotic DNA replication termination RTKN 260.9620597 277.7905067 244.1336128 0.878840734 -0.186326355 0.57841841 1 4.497927422 3.886814375 6242 rhotekin "GO:0000281,GO:0000915,GO:0005095,GO:0005515,GO:0005525,GO:0005575,GO:0005826,GO:0005829,GO:0006915,GO:0007165,GO:0007266,GO:0031106,GO:0031267,GO:0034260,GO:0042981" mitotic cytokinesis|actomyosin contractile ring assembly|GTPase inhibitor activity|protein binding|GTP binding|cellular_component|actomyosin contractile ring|cytosol|apoptotic process|signal transduction|Rho protein signal transduction|septin ring organization|small GTPase binding|negative regulation of GTPase activity|regulation of apoptotic process RTKN2 268.4135336 271.5480234 265.2790439 0.97691392 -0.03369665 0.929977066 1 1.460447337 1.402856915 219790 rhotekin 2 "GO:0005634,GO:0005737,GO:0005886,GO:0007165,GO:0008284,GO:0030097,GO:0051092,GO:1901224,GO:2001243" nucleus|cytoplasm|plasma membrane|signal transduction|positive regulation of cell population proliferation|hemopoiesis|positive regulation of NF-kappaB transcription factor activity|positive regulation of NIK/NF-kappaB signaling|negative regulation of intrinsic apoptotic signaling pathway RTL10 542.0687656 554.5405994 529.5969318 0.955019222 -0.066398324 0.810640598 1 4.448340988 4.177162419 79680 retrotransposon Gag like 10 "GO:0005515,GO:0005739,GO:0051881,GO:0097345" protein binding|mitochondrion|regulation of mitochondrial membrane potential|mitochondrial outer membrane permeabilization RTL5 6.846978582 3.121241648 10.57271552 3.38734283 1.760154008 0.229675583 1 0.038266697 0.127453365 340526 retrotransposon Gag like 5 RTL6 887.2100007 1036.252227 738.1677742 0.712343728 -0.489354541 0.049072699 1 10.20536572 7.148079198 84247 retrotransposon Gag like 6 RTL8A 1589.218113 1424.326605 1754.10962 1.231536091 0.300458907 0.20696679 1 63.13429662 76.45108767 26071 retrotransposon Gag like 8A "GO:0005515,GO:0005730" protein binding|nucleolus RTL8B 182.3013712 193.5169822 171.0857602 0.884086545 -0.17774049 0.645886066 1 5.087510182 4.422534719 441518 retrotransposon Gag like 8B "GO:0005515,GO:0005730" protein binding|nucleolus RTL8C 2549.071459 2172.384187 2925.75873 1.346796183 0.429531537 0.069409669 1 97.26187197 128.7999455 8933 retrotransposon Gag like 8C RTL9 4.964295633 4.161655531 5.766935736 1.385731158 0.470647391 0.897151737 1 0.034541199 0.047063862 57529 retrotransposon Gag like 9 RTN1 74.86575455 60.34400519 89.38750391 1.481298824 0.566862706 0.277357536 1 0.525873392 0.765940534 6252 reticulon 1 "GO:0000139,GO:0005515,GO:0005783,GO:0030176,GO:1902430" Golgi membrane|protein binding|endoplasmic reticulum|integral component of endoplasmic reticulum membrane|negative regulation of amyloid-beta formation RTN2 247.3429445 185.1936711 309.4922178 1.671181396 0.740868337 0.027777828 0.877967194 4.599090673 7.557301396 6253 reticulon 2 "GO:0005515,GO:0005783,GO:0005882,GO:0009986,GO:0014802,GO:0030018,GO:0030176,GO:0030315,GO:0046324,GO:0065002,GO:1902430" protein binding|endoplasmic reticulum|intermediate filament|cell surface|terminal cisterna|Z disc|integral component of endoplasmic reticulum membrane|T-tubule|regulation of glucose import|intracellular protein transmembrane transport|negative regulation of amyloid-beta formation RTN3 5671.727998 5499.627784 5843.828212 1.062586132 0.087579789 0.717222554 1 41.88740216 43.76417525 10313 reticulon 3 "GO:0000139,GO:0005515,GO:0005615,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0006915,GO:0016021,GO:0016032,GO:0016192,GO:0045202,GO:0071786,GO:0071787,GO:1902430" Golgi membrane|protein binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|apoptotic process|integral component of membrane|viral process|vesicle-mediated transport|synapse|endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network formation|negative regulation of amyloid-beta formation hsa05010 Alzheimer disease RTN4 8977.738227 8694.738817 9260.737636 1.065096702 0.090984421 0.714970147 1 66.48835513 69.63150906 57142 reticulon 4 "GO:0001825,GO:0003723,GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0005886,GO:0006915,GO:0007413,GO:0010634,GO:0014069,GO:0021801,GO:0030176,GO:0030308,GO:0030517,GO:0031625,GO:0033601,GO:0034165,GO:0042981,GO:0042995,GO:0043025,GO:0045296,GO:0050771,GO:0050821,GO:0051292,GO:0051897,GO:0060317,GO:0061462,GO:0071782,GO:0071786,GO:0071787,GO:0090156,GO:0098826,GO:1902430,GO:1905552,GO:1905580,GO:1990809,GO:2000172" blastocyst formation|RNA binding|protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|apoptotic process|axonal fasciculation|positive regulation of epithelial cell migration|postsynaptic density|cerebral cortex radial glia guided migration|integral component of endoplasmic reticulum membrane|negative regulation of cell growth|negative regulation of axon extension|ubiquitin protein ligase binding|positive regulation of mammary gland epithelial cell proliferation|positive regulation of toll-like receptor 9 signaling pathway|regulation of apoptotic process|cell projection|neuronal cell body|cadherin binding|negative regulation of axonogenesis|protein stabilization|nuclear pore complex assembly|positive regulation of protein kinase B signaling|cardiac epithelial to mesenchymal transition|protein localization to lysosome|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network formation|cellular sphingolipid homeostasis|endoplasmic reticulum tubular network membrane|negative regulation of amyloid-beta formation|positive regulation of protein localization to endoplasmic reticulum|positive regulation of ERBB3 signaling pathway|endoplasmic reticulum tubular network membrane organization|regulation of branching morphogenesis of a nerve hsa05010 Alzheimer disease RTN4IP1 135.26448 144.6175297 125.9114302 0.870651231 -0.199833181 0.645866631 1 2.105858599 1.802787771 84816 reticulon 4 interacting protein 1 "GO:0005515,GO:0005739,GO:0005741,GO:0007399,GO:0008270,GO:0016491,GO:0050773,GO:0055114" protein binding|mitochondrion|mitochondrial outer membrane|nervous system development|zinc ion binding|oxidoreductase activity|regulation of dendrite development|oxidation-reduction process RTN4R 48.55788307 50.98028025 46.13548589 0.904967287 -0.144062453 0.843162759 1 1.39954931 1.245352404 65078 reticulon 4 receptor "GO:0005515,GO:0005783,GO:0005886,GO:0005887,GO:0007166,GO:0008201,GO:0009986,GO:0010977,GO:0022038,GO:0023041,GO:0030517,GO:0031362,GO:0035025,GO:0035374,GO:0038023,GO:0038131,GO:0043005,GO:0043025,GO:0043198,GO:0043204,GO:0043547,GO:0044295,GO:0045121,GO:0048681,GO:0050771,GO:0070062,GO:1905573,GO:1905576" protein binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|heparin binding|cell surface|negative regulation of neuron projection development|corpus callosum development|neuronal signal transduction|negative regulation of axon extension|anchored component of external side of plasma membrane|positive regulation of Rho protein signal transduction|chondroitin sulfate binding|signaling receptor activity|neuregulin receptor activity|neuron projection|neuronal cell body|dendritic shaft|perikaryon|positive regulation of GTPase activity|axonal growth cone|membrane raft|negative regulation of axon regeneration|negative regulation of axonogenesis|extracellular exosome|ganglioside GM1 binding|ganglioside GT1b binding RTN4RL2 18.81173823 27.05076095 10.57271552 0.39084725 -1.355323209 0.123788254 1 0.649122929 0.249462453 349667 reticulon 4 receptor like 2 "GO:0005576,GO:0005615,GO:0005886,GO:0007166,GO:0009897,GO:0009986,GO:0010977,GO:0030424,GO:0030425,GO:0031012,GO:0031103,GO:0038023,GO:0043005,GO:0043204,GO:0045121,GO:0046658,GO:0070062" extracellular region|extracellular space|plasma membrane|cell surface receptor signaling pathway|external side of plasma membrane|cell surface|negative regulation of neuron projection development|axon|dendrite|extracellular matrix|axon regeneration|signaling receptor activity|neuron projection|perikaryon|membrane raft|anchored component of plasma membrane|extracellular exosome RTP1 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.075237096 0 132112 receptor transporter protein 1 "GO:0001580,GO:0005886,GO:0006612,GO:0009986,GO:0016021,GO:0031849,GO:0051205" detection of chemical stimulus involved in sensory perception of bitter taste|plasma membrane|protein targeting to membrane|cell surface|integral component of membrane|olfactory receptor binding|protein insertion into membrane RTRAF 2294.463895 2225.445295 2363.482496 1.062026778 0.086820143 0.714601821 1 16.94989656 17.70001759 51637 "RNA transcription, translation and transport factor" "GO:0000993,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006388,GO:0006469,GO:0016032,GO:0042802,GO:0045944,GO:0048471,GO:0050658,GO:0072669,GO:0072686" "RNA polymerase II complex binding|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|tRNA splicing, via endonucleolytic cleavage and ligation|negative regulation of protein kinase activity|viral process|identical protein binding|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|RNA transport|tRNA-splicing ligase complex|mitotic spindle" RTTN 1160.088359 1160.061479 1160.115239 1.000046342 6.69E-05 1 1 4.783307505 4.703483291 25914 rotatin "GO:0005737,GO:0005813,GO:0005814,GO:0007099,GO:0007368,GO:0010457,GO:0032053,GO:0036064" cytoplasm|centrosome|centriole|centriole replication|determination of left/right symmetry|centriole-centriole cohesion|ciliary basal body organization|ciliary basal body RUBCN 737.1325061 780.310412 693.9546002 0.889331463 -0.169206868 0.50784725 1 4.239842449 3.70752898 9711 rubicon autophagy regulator "GO:0002376,GO:0005515,GO:0005654,GO:0005764,GO:0005769,GO:0005770,GO:0005794,GO:0005829,GO:0006897,GO:0006909,GO:0006914,GO:0010507,GO:0043231,GO:0043553,GO:0045806,GO:0071985,GO:1901097,GO:1901981" immune system process|protein binding|nucleoplasm|lysosome|early endosome|late endosome|Golgi apparatus|cytosol|endocytosis|phagocytosis|autophagy|negative regulation of autophagy|intracellular membrane-bounded organelle|negative regulation of phosphatidylinositol 3-kinase activity|negative regulation of endocytosis|multivesicular body sorting pathway|negative regulation of autophagosome maturation|phosphatidylinositol phosphate binding hsa04140 Autophagy - animal RUFY1 534.5877236 534.7727357 534.4027115 0.999308072 -0.000998586 1 1 8.135643681 7.993969622 80230 RUN and FYVE domain containing 1 "GO:0005515,GO:0005737,GO:0005768,GO:0005829,GO:0006661,GO:0006897,GO:0007264,GO:0008289,GO:0015031,GO:0016607,GO:0017124,GO:0030100,GO:0031901,GO:0042169,GO:0043231,GO:0046872" protein binding|cytoplasm|endosome|cytosol|phosphatidylinositol biosynthetic process|endocytosis|small GTPase mediated signal transduction|lipid binding|protein transport|nuclear speck|SH3 domain binding|regulation of endocytosis|early endosome membrane|SH2 domain binding|intracellular membrane-bounded organelle|metal ion binding hsa04144 Endocytosis RUFY2 756.7273771 752.2192372 761.2355171 1.01198624 0.017189673 0.951598128 1 5.700732486 5.672525378 55680 RUN and FYVE domain containing 2 "GO:0005634,GO:0005737,GO:0005768,GO:0008150,GO:0017124,GO:0030100,GO:0046872" nucleus|cytoplasm|endosome|biological_process|SH3 domain binding|regulation of endocytosis|metal ion binding RUFY3 469.0410346 504.6007331 433.4813362 0.859058078 -0.219172424 0.431775699 1 3.334936682 2.816964004 22902 RUN and FYVE domain containing 3 "GO:0005515,GO:0005737,GO:0005829,GO:0007015,GO:0012505,GO:0016020,GO:0030027,GO:0030054,GO:0030175,GO:0030335,GO:0030424,GO:0030425,GO:0030426,GO:0043025,GO:0043204,GO:0045773,GO:0050770,GO:0050771,GO:0071437,GO:0090316,GO:2000114" protein binding|cytoplasm|cytosol|actin filament organization|endomembrane system|membrane|lamellipodium|cell junction|filopodium|positive regulation of cell migration|axon|dendrite|growth cone|neuronal cell body|perikaryon|positive regulation of axon extension|regulation of axonogenesis|negative regulation of axonogenesis|invadopodium|positive regulation of intracellular protein transport|regulation of establishment of cell polarity RUNDC1 593.9806337 630.4908129 557.4704545 0.884184897 -0.177580003 0.502724783 1 6.303509908 5.480203816 146923 RUN domain containing 1 "GO:0001701,GO:0005096,GO:0006886,GO:0090630" in utero embryonic development|GTPase activator activity|intracellular protein transport|activation of GTPase activity RUNDC3A 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.055122156 10900 RUN domain containing 3A "GO:0005515,GO:0005829,GO:0005886,GO:0007264,GO:0010753,GO:0030695,GO:0043231,GO:0050790" protein binding|cytosol|plasma membrane|small GTPase mediated signal transduction|positive regulation of cGMP-mediated signaling|GTPase regulator activity|intracellular membrane-bounded organelle|regulation of catalytic activity RUNDC3B 106.8562734 80.11186896 133.6006779 1.667676458 0.737839422 0.107088853 1 0.906193982 1.485949843 154661 RUN domain containing 3B RUNX1 1411.299851 1484.670611 1337.929091 0.901162238 -0.150141234 0.531674504 1 9.145214886 8.10341495 861 RUNX family transcription factor 1 "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001503,GO:0001959,GO:0002062,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006357,GO:0010629,GO:0010755,GO:0016513,GO:0030097,GO:0030111,GO:0030182,GO:0030854,GO:0032743,GO:0032967,GO:0033146,GO:0043231,GO:0043371,GO:0043378,GO:0045589,GO:0045595,GO:0045616,GO:0045637,GO:0045652,GO:0045766,GO:0045893,GO:0045944,GO:0048935,GO:0050855,GO:0060043,GO:0061026,GO:0071425,GO:1902036,GO:1903055,GO:1905203,GO:2000810" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|ossification|regulation of cytokine-mediated signaling pathway|chondrocyte differentiation|protein binding|ATP binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|negative regulation of gene expression|regulation of plasminogen activation|core-binding factor complex|hemopoiesis|regulation of Wnt signaling pathway|neuron differentiation|positive regulation of granulocyte differentiation|positive regulation of interleukin-2 production|positive regulation of collagen biosynthetic process|regulation of intracellular estrogen receptor signaling pathway|intracellular membrane-bounded organelle|negative regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|regulation of regulatory T cell differentiation|regulation of cell differentiation|regulation of keratinocyte differentiation|regulation of myeloid cell differentiation|regulation of megakaryocyte differentiation|positive regulation of angiogenesis|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|peripheral nervous system neuron development|regulation of B cell receptor signaling pathway|regulation of cardiac muscle cell proliferation|cardiac muscle tissue regeneration|hematopoietic stem cell proliferation|regulation of hematopoietic stem cell differentiation|positive regulation of extracellular matrix organization|regulation of connective tissue replacement|regulation of bicellular tight junction assembly" "hsa04530,hsa04659,hsa05200,hsa05202,hsa05220,hsa05221" Tight junction|Th17 cell differentiation|Pathways in cancer|Transcriptional misregulation in cancer|Chronic myeloid leukemia|Acute myeloid leukemia Runt RUNX1T1 11.04826308 12.48496659 9.61155956 0.769850643 -0.377349516 0.799003187 1 0.038137469 0.028868853 862 RUNX1 partner transcriptional co-repressor 1 "GO:0003677,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006351,GO:0016363,GO:0045599,GO:0045892,GO:0046872" "DNA binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription, DNA-templated|nuclear matrix|negative regulation of fat cell differentiation|negative regulation of transcription, DNA-templated|metal ion binding" "hsa05200,hsa05202,hsa05221" Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia other RUNX2 521.9190891 568.0659799 475.7721982 0.837529821 -0.255787536 0.345737459 1 5.17525389 4.261898655 860 RUNX family transcription factor 2 "GO:0000785,GO:0000978,GO:0000981,GO:0001503,GO:0001649,GO:0002062,GO:0003700,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006367,GO:0030097,GO:0030182,GO:0030509,GO:0045595,GO:0045669,GO:0045892,GO:0045893,GO:0045944,GO:0071773,GO:1901522,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|ossification|osteoblast differentiation|chondrocyte differentiation|DNA-binding transcription factor activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|hemopoiesis|neuron differentiation|BMP signaling pathway|regulation of cell differentiation|positive regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cellular response to BMP stimulus|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|sequence-specific double-stranded DNA binding" "hsa04928,hsa05202" "Parathyroid hormone synthesis, secretion and action|Transcriptional misregulation in cancer" Runt RUSC1 1036.362167 1103.879129 968.8452036 0.877673269 -0.188244127 0.443399603 1 11.62430945 10.03162323 23623 RUN and SH3 domain containing 1 "GO:0000209,GO:0003779,GO:0005515,GO:0005634,GO:0005769,GO:0005794,GO:0005829,GO:0005874,GO:0014069,GO:0015630,GO:0031410" protein polyubiquitination|actin binding|protein binding|nucleus|early endosome|Golgi apparatus|cytosol|microtubule|postsynaptic density|microtubule cytoskeleton|cytoplasmic vesicle RUSC2 3259.710582 3304.354491 3215.066673 0.972978741 -0.039519812 0.868750381 1 30.94898667 29.60881073 9853 RUN and SH3 domain containing 2 "GO:0005515,GO:0005829,GO:0008150,GO:0031267,GO:0031410,GO:0070062" protein binding|cytosol|biological_process|small GTPase binding|cytoplasmic vesicle|extracellular exosome RUSF1 1462.900332 1438.8924 1486.908264 1.033370017 0.04735693 0.845501395 1 27.59290075 28.03653857 64755 RUS family member 1 "GO:0005515,GO:0016020,GO:0016021" protein binding|membrane|integral component of membrane RUVBL1 1612.680916 1636.571037 1588.790795 0.970804664 -0.042747056 0.85981115 1 31.40625256 29.9791387 8607 RuvB like AAA ATPase 1 "GO:0000492,GO:0000812,GO:0001094,GO:0003678,GO:0003713,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005815,GO:0005829,GO:0006281,GO:0006310,GO:0006338,GO:0006357,GO:0007049,GO:0007283,GO:0016020,GO:0016363,GO:0016573,GO:0016579,GO:0016887,GO:0017025,GO:0031011,GO:0032508,GO:0034080,GO:0035267,GO:0040008,GO:0043139,GO:0043531,GO:0043967,GO:0043968,GO:0045296,GO:0045893,GO:0051117,GO:0051301,GO:0070062,GO:0071339,GO:0090263,GO:0097255,GO:1904837,GO:1904874,GO:1990904" "box C/D snoRNP assembly|Swr1 complex|TFIID-class transcription factor complex binding|DNA helicase activity|transcription coactivator activity|protein binding|ATP binding|nucleus|nucleoplasm|microtubule organizing center|cytosol|DNA repair|DNA recombination|chromatin remodeling|regulation of transcription by RNA polymerase II|cell cycle|spermatogenesis|membrane|nuclear matrix|histone acetylation|protein deubiquitination|ATPase activity|TBP-class protein binding|Ino80 complex|DNA duplex unwinding|CENP-A containing nucleosome assembly|NuA4 histone acetyltransferase complex|regulation of growth|5'-3' DNA helicase activity|ADP binding|histone H4 acetylation|histone H2A acetylation|cadherin binding|positive regulation of transcription, DNA-templated|ATPase binding|cell division|extracellular exosome|MLL1 complex|positive regulation of canonical Wnt signaling pathway|R2TP complex|beta-catenin-TCF complex assembly|positive regulation of telomerase RNA localization to Cajal body|ribonucleoprotein complex" hsa04310 Wnt signaling pathway RUVBL2 1741.892226 1597.03531 1886.749142 1.18140728 0.240506407 0.311056886 1 35.52765288 41.27027267 10856 RuvB like AAA ATPase 2 "GO:0000492,GO:0000791,GO:0000812,GO:0000978,GO:0000979,GO:0001094,GO:0003678,GO:0003714,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006281,GO:0006310,GO:0006338,GO:0006357,GO:0006457,GO:0008013,GO:0016020,GO:0016363,GO:0016573,GO:0016887,GO:0017025,GO:0031011,GO:0031490,GO:0032508,GO:0034644,GO:0035066,GO:0035267,GO:0040008,GO:0042802,GO:0042803,GO:0043139,GO:0043531,GO:0043967,GO:0043968,GO:0045892,GO:0045944,GO:0051082,GO:0051117,GO:0070062,GO:0071169,GO:0071339,GO:0071392,GO:0071733,GO:0071899,GO:0090090,GO:0097255,GO:1904874,GO:1990904" "box C/D snoRNP assembly|euchromatin|Swr1 complex|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|TFIID-class transcription factor complex binding|DNA helicase activity|transcription corepressor activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|DNA repair|DNA recombination|chromatin remodeling|regulation of transcription by RNA polymerase II|protein folding|beta-catenin binding|membrane|nuclear matrix|histone acetylation|ATPase activity|TBP-class protein binding|Ino80 complex|chromatin DNA binding|DNA duplex unwinding|cellular response to UV|positive regulation of histone acetylation|NuA4 histone acetyltransferase complex|regulation of growth|identical protein binding|protein homodimerization activity|5'-3' DNA helicase activity|ADP binding|histone H4 acetylation|histone H2A acetylation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|unfolded protein binding|ATPase binding|extracellular exosome|establishment of protein localization to chromatin|MLL1 complex|cellular response to estradiol stimulus|transcriptional activation by promoter-enhancer looping|negative regulation of estrogen receptor binding|negative regulation of canonical Wnt signaling pathway|R2TP complex|positive regulation of telomerase RNA localization to Cajal body|ribonucleoprotein complex" RWDD1 667.6185047 557.6618411 777.5751684 1.394348889 0.479591592 0.063185925 1 5.289032792 7.251350425 51389 RWD domain containing 1 "GO:0002181,GO:0005515,GO:0005844" cytoplasmic translation|protein binding|polysome RWDD2A 248.9230726 239.295193 258.5509522 1.080468642 0.111657202 0.748773554 1 2.911042773 3.092658255 112611 RWD domain containing 2A GO:0005515 protein binding RWDD2B 484.6623341 498.3582498 470.9664184 0.945035863 -0.081559017 0.773173945 1 8.408619617 7.813474062 10069 RWD domain containing 2B "GO:0003674,GO:0005515,GO:0005575,GO:0008150" molecular_function|protein binding|cellular_component|biological_process RWDD3 151.2474705 135.2538047 167.2411363 1.236498571 0.306260573 0.454430173 1 5.701616882 6.932068239 25950 RWD domain containing 3 "GO:0005515,GO:0005634,GO:0005737,GO:0032088,GO:0033235,GO:1902073" protein binding|nucleus|cytoplasm|negative regulation of NF-kappaB transcription factor activity|positive regulation of protein sumoylation|positive regulation of hypoxia-inducible factor-1alpha signaling pathway RWDD4 252.173262 223.6889848 280.6575392 1.254677513 0.327316599 0.329235786 1 4.589723181 5.662259719 201965 RWD domain containing 4 GO:0005515 protein binding RXRA 1812.262973 1880.027886 1744.49806 0.927910736 -0.107942068 0.650135742 1 13.67129485 12.47346257 6256 retinoid X receptor alpha "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001972,GO:0003690,GO:0003700,GO:0003707,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006357,GO:0006367,GO:0008203,GO:0008270,GO:0015721,GO:0016922,GO:0019048,GO:0019216,GO:0019899,GO:0030154,GO:0032526,GO:0035357,GO:0042277,GO:0042802,GO:0042809,GO:0043235,GO:0043401,GO:0043565,GO:0044323,GO:0045893,GO:0045944,GO:0048384,GO:0048856,GO:0050692,GO:0050693,GO:0070644,GO:0090575,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|retinoic acid binding|double-stranded DNA binding|DNA-binding transcription factor activity|steroid hormone receptor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|cholesterol metabolic process|zinc ion binding|bile acid and bile salt transport|nuclear receptor binding|modulation by virus of host process|regulation of lipid metabolic process|enzyme binding|cell differentiation|response to retinoic acid|peroxisome proliferator activated receptor signaling pathway|peptide binding|identical protein binding|vitamin D receptor binding|receptor complex|steroid hormone mediated signaling pathway|sequence-specific DNA binding|retinoic acid-responsive element binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|retinoic acid receptor signaling pathway|anatomical structure development|DNA binding domain binding|LBD domain binding|vitamin D response element binding|RNA polymerase II transcription regulator complex|sequence-specific double-stranded DNA binding" "hsa03320,hsa04151,hsa04659,hsa04919,hsa04920,hsa04928,hsa04932,hsa04976,hsa05160,hsa05200,hsa05202,hsa05216,hsa05222,hsa05223,hsa05226" "PPAR signaling pathway|PI3K-Akt signaling pathway|Th17 cell differentiation|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Parathyroid hormone synthesis, secretion and action|Non-alcoholic fatty liver disease|Bile secretion|Hepatitis C|Pathways in cancer|Transcriptional misregulation in cancer|Thyroid cancer|Small cell lung cancer|Non-small cell lung cancer|Gastric cancer" ThyrH_rcpt RXRB 753.5168167 768.8658593 738.1677742 0.960073549 -0.058783163 0.821305314 1 13.55117496 12.79241782 6257 retinoid X receptor beta "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0003707,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006367,GO:0008270,GO:0030154,GO:0032526,GO:0043401,GO:0044323,GO:0045893,GO:0045944,GO:0048384,GO:0048856,GO:0090575,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|steroid hormone receptor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|zinc ion binding|cell differentiation|response to retinoic acid|steroid hormone mediated signaling pathway|retinoic acid-responsive element binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|retinoic acid receptor signaling pathway|anatomical structure development|RNA polymerase II transcription regulator complex|sequence-specific double-stranded DNA binding" "hsa03320,hsa04659,hsa04919,hsa04920,hsa04928,hsa05200,hsa05202,hsa05216,hsa05222,hsa05223,hsa05226" "PPAR signaling pathway|Th17 cell differentiation|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Parathyroid hormone synthesis, secretion and action|Pathways in cancer|Transcriptional misregulation in cancer|Thyroid cancer|Small cell lung cancer|Non-small cell lung cancer|Gastric cancer" RXYLT1 326.71634 389.1147921 264.3178879 0.679279979 -0.557921761 0.06848224 1 8.503825263 5.679816707 10329 ribitol xylosyltransferase 1 "GO:0000139,GO:0005515,GO:0005654,GO:0005794,GO:0005887,GO:0035269,GO:0120053" "Golgi membrane|protein binding|nucleoplasm|Golgi apparatus|integral component of plasma membrane|protein O-linked mannosylation|ribitol beta-1,4-xylosyltransferase activity" hsa00515 Mannose type O-glycan biosynthesis RYBP 713.8716488 762.623376 665.1199215 0.872147304 -0.19735627 0.441337102 1 9.148080003 7.844964368 23429 RING1 and YY1 binding protein "GO:0000122,GO:0003677,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006915,GO:0007275,GO:0031519,GO:0032435,GO:0035518,GO:0043065,GO:0045893,GO:0046872,GO:0070317" "negative regulation of transcription by RNA polymerase II|DNA binding|transcription coregulator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|apoptotic process|multicellular organism development|PcG protein complex|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|histone H2A monoubiquitination|positive regulation of apoptotic process|positive regulation of transcription, DNA-templated|metal ion binding|negative regulation of G0 to G1 transition" other RYK 1559.911074 1702.117112 1417.705035 0.832906869 -0.263772904 0.26827837 1 29.70531783 24.32774337 6259 receptor like tyrosine kinase "GO:0004713,GO:0004714,GO:0004888,GO:0005109,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005886,GO:0005887,GO:0006468,GO:0007165,GO:0007169,GO:0007275,GO:0007409,GO:0007411,GO:0007416,GO:0016020,GO:0016021,GO:0016055,GO:0017147,GO:0018108,GO:0022008,GO:0022038,GO:0030182,GO:0031175,GO:0033278,GO:0033674,GO:0035567,GO:0036518,GO:0042813,GO:0043235,GO:0043410,GO:0048705,GO:0048843,GO:0060070,GO:0071679,GO:1904929,GO:1904938,GO:1904948,GO:1904953" "protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|transmembrane signaling receptor activity|frizzled binding|protein binding|ATP binding|nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|protein phosphorylation|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axonogenesis|axon guidance|synapse assembly|membrane|integral component of membrane|Wnt signaling pathway|Wnt-protein binding|peptidyl-tyrosine phosphorylation|neurogenesis|corpus callosum development|neuron differentiation|neuron projection development|cell proliferation in midbrain|positive regulation of kinase activity|non-canonical Wnt signaling pathway|chemorepulsion of dopaminergic neuron axon|Wnt-activated receptor activity|receptor complex|positive regulation of MAPK cascade|skeletal system morphogenesis|negative regulation of axon extension involved in axon guidance|canonical Wnt signaling pathway|commissural neuron axon guidance|coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway|planar cell polarity pathway involved in axon guidance|midbrain dopaminergic neuron differentiation|Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" "hsa04310,hsa04360" Wnt signaling pathway|Axon guidance RYR2 7.68421723 12.48496659 2.883467868 0.230955193 -2.11431511 0.122989943 1 0.040847212 0.009276013 6262 ryanodine receptor 2 "GO:0001666,GO:0002027,GO:0003143,GO:0003220,GO:0003300,GO:0005219,GO:0005262,GO:0005509,GO:0005513,GO:0005515,GO:0005516,GO:0005790,GO:0005886,GO:0006816,GO:0006874,GO:0010460,GO:0010881,GO:0010882,GO:0014701,GO:0014808,GO:0014850,GO:0015278,GO:0016020,GO:0016529,GO:0019722,GO:0019899,GO:0030018,GO:0030659,GO:0031000,GO:0032991,GO:0033017,GO:0034220,GO:0034236,GO:0034237,GO:0034704,GO:0035584,GO:0035994,GO:0042383,GO:0042802,GO:0043621,GO:0043924,GO:0044325,GO:0048763,GO:0051209,GO:0051284,GO:0051480,GO:0051775,GO:0055117,GO:0060048,GO:0060402,GO:0070296,GO:0071313,GO:0071872,GO:0072599,GO:0086005,GO:0086029,GO:0086064,GO:0097050,GO:0098735,GO:0098904,GO:0098907,GO:0098910,GO:0098911,GO:1901896,GO:1903779" response to hypoxia|regulation of heart rate|embryonic heart tube morphogenesis|left ventricular cardiac muscle tissue morphogenesis|cardiac muscle hypertrophy|ryanodine-sensitive calcium-release channel activity|calcium channel activity|calcium ion binding|detection of calcium ion|protein binding|calmodulin binding|smooth endoplasmic reticulum|plasma membrane|calcium ion transport|cellular calcium ion homeostasis|positive regulation of heart rate|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of cardiac muscle contraction by calcium ion signaling|junctional sarcoplasmic reticulum membrane|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to muscle activity|calcium-release channel activity|membrane|sarcoplasmic reticulum|calcium-mediated signaling|enzyme binding|Z disc|cytoplasmic vesicle membrane|response to caffeine|protein-containing complex|sarcoplasmic reticulum membrane|ion transmembrane transport|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|calcium channel complex|calcium-mediated signaling using intracellular calcium source|response to muscle stretch|sarcolemma|identical protein binding|protein self-association|suramin binding|ion channel binding|calcium-induced calcium release activity|release of sequestered calcium ion into cytosol|positive regulation of sequestering of calcium ion|regulation of cytosolic calcium ion concentration|response to redox state|regulation of cardiac muscle contraction|cardiac muscle contraction|calcium ion transport into cytosol|sarcoplasmic reticulum calcium ion transport|cellular response to caffeine|cellular response to epinephrine stimulus|establishment of protein localization to endoplasmic reticulum|ventricular cardiac muscle cell action potential|Purkinje myocyte to ventricular cardiac muscle cell signaling|cell communication by electrical coupling involved in cardiac conduction|type B pancreatic cell apoptotic process|positive regulation of the force of heart contraction|regulation of AV node cell action potential|regulation of SA node cell action potential|regulation of atrial cardiac muscle cell action potential|regulation of ventricular cardiac muscle cell action potential|positive regulation of ATPase-coupled calcium transmembrane transporter activity|regulation of cardiac conduction "hsa04020,hsa04024,hsa04260,hsa04261,hsa04371,hsa04713,hsa04911,hsa04921,hsa04972,hsa05020,hsa05022,hsa05410,hsa05412,hsa05414" Calcium signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Apelin signaling pathway|Circadian entrainment|Insulin secretion|Oxytocin signaling pathway|Pancreatic secretion|Prion disease|Pathways of neurodegeneration - multiple diseases|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy S100A1 25.33665469 34.33365813 16.33965125 0.47590767 -1.071246388 0.169114348 1 3.27786088 1.533855331 6271 S100 calcium binding protein A1 "GO:0002224,GO:0005509,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0008016,GO:0016529,GO:0021762,GO:0032991,GO:0035556,GO:0042802,GO:0042803,GO:0044548,GO:0048306,GO:0051000,GO:0051117,GO:1903672" toll-like receptor signaling pathway|calcium ion binding|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|regulation of heart contraction|sarcoplasmic reticulum|substantia nigra development|protein-containing complex|intracellular signal transduction|identical protein binding|protein homodimerization activity|S100 protein binding|calcium-dependent protein binding|positive regulation of nitric-oxide synthase activity|ATPase binding|positive regulation of sprouting angiogenesis S100A10 5549.924617 4547.649081 6552.200152 1.440788424 0.526858495 0.029233551 0.88444427 361.6984698 512.4105472 6281 S100 calcium binding protein A10 "GO:0001765,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005783,GO:0006900,GO:0008289,GO:0019897,GO:0042493,GO:0042803,GO:0043547,GO:0044325,GO:0045121,GO:0048306,GO:0051099,GO:0051496,GO:0051894,GO:0062023,GO:0070062,GO:0072659,GO:1900026,GO:1990665" membrane raft assembly|calcium ion binding|protein binding|extracellular region|extracellular space|cytoplasm|endoplasmic reticulum|vesicle budding from membrane|lipid binding|extrinsic component of plasma membrane|response to drug|protein homodimerization activity|positive regulation of GTPase activity|ion channel binding|membrane raft|calcium-dependent protein binding|positive regulation of binding|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|collagen-containing extracellular matrix|extracellular exosome|protein localization to plasma membrane|positive regulation of substrate adhesion-dependent cell spreading|AnxA2-p11 complex hsa05132 Salmonella infection S100A11 5998.660646 5351.889012 6645.43228 1.241698448 0.312314851 0.197322204 1 507.3187926 619.3958155 6282 S100 calcium binding protein A11 "GO:0001726,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005912,GO:0007165,GO:0008156,GO:0008285,GO:0014911,GO:0034774,GO:0042803,GO:0043312,GO:0044548,GO:0048306,GO:0070062,GO:0098609,GO:0098641" ruffle|calcium ion binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|adherens junction|signal transduction|negative regulation of DNA replication|negative regulation of cell population proliferation|positive regulation of smooth muscle cell migration|secretory granule lumen|protein homodimerization activity|neutrophil degranulation|S100 protein binding|calcium-dependent protein binding|extracellular exosome|cell-cell adhesion|cadherin binding involved in cell-cell adhesion S100A13 1561.879888 1387.912119 1735.847657 1.25068989 0.322724116 0.175558268 1 39.1492172 48.1441918 6284 S100 calcium binding protein A13 "GO:0001816,GO:0005507,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0008270,GO:0008284,GO:0008289,GO:0008360,GO:0015031,GO:0017134,GO:0032610,GO:0042803,GO:0043123,GO:0043303,GO:0046688,GO:0048306,GO:0048471,GO:0050786,GO:0051602" cytokine production|copper ion binding|calcium ion binding|protein binding|extracellular region|extracellular space|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|zinc ion binding|positive regulation of cell population proliferation|lipid binding|regulation of cell shape|protein transport|fibroblast growth factor binding|interleukin-1 alpha production|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|mast cell degranulation|response to copper ion|calcium-dependent protein binding|perinuclear region of cytoplasm|RAGE receptor binding|response to electrical stimulus S100A14 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.144470885 0.131231845 57402 S100 calcium binding protein A14 "GO:0005509,GO:0005515,GO:0005615,GO:0006915,GO:0032496,GO:0034142,GO:0042379,GO:0042742,GO:0048306,GO:0048471,GO:0055074,GO:0070062,GO:0071624,GO:0090026" calcium ion binding|protein binding|extracellular space|apoptotic process|response to lipopolysaccharide|toll-like receptor 4 signaling pathway|chemokine receptor binding|defense response to bacterium|calcium-dependent protein binding|perinuclear region of cytoplasm|calcium ion homeostasis|extracellular exosome|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis S100A16 4597.734867 4757.812685 4437.657049 0.932709491 -0.100500297 0.674865933 1 155.5856118 142.6878542 140576 S100 calcium binding protein A16 "GO:0003723,GO:0005509,GO:0005515,GO:0005615,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0042803,GO:0048306,GO:0051592,GO:0070062" RNA binding|calcium ion binding|protein binding|extracellular space|nucleus|nucleolus|cytoplasm|cytosol|plasma membrane|protein homodimerization activity|calcium-dependent protein binding|response to calcium ion|extracellular exosome S100A2 1180.624264 1181.910171 1179.338358 0.99782402 -0.003142696 0.993647987 1 57.39433444 56.31111891 6273 S100 calcium binding protein A2 "GO:0005509,GO:0005515,GO:0005575,GO:0042802,GO:0043542,GO:0046914,GO:0048306" calcium ion binding|protein binding|cellular_component|identical protein binding|endothelial cell migration|transition metal ion binding|calcium-dependent protein binding S100A3 45.71404416 52.02069413 39.4073942 0.757533033 -0.400619295 0.532711404 1 3.74157525 2.786937556 6274 S100 calcium binding protein A3 "GO:0005509,GO:0005515,GO:0005794,GO:0005829,GO:0005886,GO:0008270,GO:0048306" calcium ion binding|protein binding|Golgi apparatus|cytosol|plasma membrane|zinc ion binding|calcium-dependent protein binding S100A4 17.05297259 18.72744989 15.3784953 0.821174019 -0.284240111 0.809190529 1 1.778380037 1.435922345 6275 S100 calcium binding protein A4 "GO:0001837,GO:0003723,GO:0003779,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0042802,GO:0043005,GO:0043123,GO:0046914,GO:0048306,GO:0048471,GO:0050786,GO:0062023,GO:0070062" epithelial to mesenchymal transition|RNA binding|actin binding|calcium ion binding|protein binding|extracellular region|extracellular space|nucleus|identical protein binding|neuron projection|positive regulation of I-kappaB kinase/NF-kappaB signaling|transition metal ion binding|calcium-dependent protein binding|perinuclear region of cytoplasm|RAGE receptor binding|collagen-containing extracellular matrix|extracellular exosome S100A5 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.080626781 0.073238295 6276 S100 calcium binding protein A5 "GO:0005507,GO:0005509,GO:0005515,GO:0005634,GO:0008270,GO:0042803,GO:0043025,GO:0048306" copper ion binding|calcium ion binding|protein binding|nucleus|zinc ion binding|protein homodimerization activity|neuronal cell body|calcium-dependent protein binding S100A6 8778.225981 8377.412583 9179.03938 1.095689067 0.131838451 0.59584471 1 1030.154637 1109.841419 6277 S100 calcium binding protein A6 "GO:0001726,GO:0005509,GO:0005515,GO:0005523,GO:0005576,GO:0005634,GO:0005635,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0007409,GO:0008270,GO:0015075,GO:0031234,GO:0034220,GO:0042803,GO:0044548,GO:0048146,GO:0048306,GO:0048471,GO:0062023,GO:0070062" ruffle|calcium ion binding|protein binding|tropomyosin binding|extracellular region|nucleus|nuclear envelope|cytoplasm|cytosol|plasma membrane|signal transduction|axonogenesis|zinc ion binding|ion transmembrane transporter activity|extrinsic component of cytoplasmic side of plasma membrane|ion transmembrane transport|protein homodimerization activity|S100 protein binding|positive regulation of fibroblast proliferation|calcium-dependent protein binding|perinuclear region of cytoplasm|collagen-containing extracellular matrix|extracellular exosome S100P 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.353662272 0 6286 S100 calcium binding protein P "GO:0000287,GO:0005509,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0010033,GO:0016604,GO:0031528,GO:0034774,GO:0042803,GO:0043312,GO:0043542,GO:0045296,GO:0046914,GO:0048306,GO:0070062" magnesium ion binding|calcium ion binding|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|response to organic substance|nuclear body|microvillus membrane|secretory granule lumen|protein homodimerization activity|neutrophil degranulation|endothelial cell migration|cadherin binding|transition metal ion binding|calcium-dependent protein binding|extracellular exosome S100PBP 738.1880112 744.93634 731.4396825 0.981882133 -0.026378244 0.922927455 1 7.316136056 7.063375739 64766 S100P binding protein "GO:0005515,GO:0005634,GO:0005829,GO:0016607,GO:0048306" protein binding|nucleus|cytosol|nuclear speck|calcium-dependent protein binding S100Z 3.403674809 1.040413883 5.766935736 5.54292463 2.470647391 0.304382079 1 0.010550062 0.057499645 170591 S100 calcium binding protein Z "GO:0005509,GO:0005515,GO:0008150,GO:0042803,GO:0048306" calcium ion binding|protein binding|biological_process|protein homodimerization activity|calcium-dependent protein binding S1PR1 310.1546206 244.4972624 375.8119788 1.537080518 0.620192741 0.046517036 1 4.544886635 6.868957852 1901 sphingosine-1-phosphate receptor 1 "GO:0001525,GO:0001664,GO:0001955,GO:0003245,GO:0003376,GO:0004930,GO:0005515,GO:0005654,GO:0005737,GO:0005768,GO:0005886,GO:0006935,GO:0007155,GO:0007186,GO:0007189,GO:0007193,GO:0007420,GO:0009897,GO:0016021,GO:0016477,GO:0019221,GO:0019222,GO:0019226,GO:0030032,GO:0030155,GO:0030182,GO:0030335,GO:0030500,GO:0030595,GO:0031226,GO:0031532,GO:0038036,GO:0043231,GO:0043547,GO:0045121,GO:0045124,GO:0045446,GO:0045944,GO:0046625,GO:0048661,GO:0050927,GO:0051482,GO:0051497,GO:0061384,GO:0072678" angiogenesis|G protein-coupled receptor binding|blood vessel maturation|cardiac muscle tissue growth involved in heart morphogenesis|sphingosine-1-phosphate receptor signaling pathway|G protein-coupled receptor activity|protein binding|nucleoplasm|cytoplasm|endosome|plasma membrane|chemotaxis|cell adhesion|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|brain development|external side of plasma membrane|integral component of membrane|cell migration|cytokine-mediated signaling pathway|regulation of metabolic process|transmission of nerve impulse|lamellipodium assembly|regulation of cell adhesion|neuron differentiation|positive regulation of cell migration|regulation of bone mineralization|leukocyte chemotaxis|intrinsic component of plasma membrane|actin cytoskeleton reorganization|sphingosine-1-phosphate receptor activity|intracellular membrane-bounded organelle|positive regulation of GTPase activity|membrane raft|regulation of bone resorption|endothelial cell differentiation|positive regulation of transcription by RNA polymerase II|sphingolipid binding|positive regulation of smooth muscle cell proliferation|positive regulation of positive chemotaxis|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|negative regulation of stress fiber assembly|heart trabecula morphogenesis|T cell migration "hsa04068,hsa04071,hsa04080" FoxO signaling pathway|Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction S1PR2 118.0976509 110.2838716 125.9114302 1.141703029 0.191187437 0.677979904 1 1.615604593 1.813674768 9294 sphingosine-1-phosphate receptor 2 "GO:0000187,GO:0001664,GO:0003376,GO:0004930,GO:0005178,GO:0005515,GO:0005737,GO:0005886,GO:0007186,GO:0007189,GO:0008284,GO:0008289,GO:0010800,GO:0016021,GO:0019222,GO:0031532,GO:0038036,GO:0046847,GO:0090394,GO:1903142" activation of MAPK activity|G protein-coupled receptor binding|sphingosine-1-phosphate receptor signaling pathway|G protein-coupled receptor activity|integrin binding|protein binding|cytoplasm|plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cell population proliferation|lipid binding|positive regulation of peptidyl-threonine phosphorylation|integral component of membrane|regulation of metabolic process|actin cytoskeleton reorganization|sphingosine-1-phosphate receptor activity|filopodium assembly|negative regulation of excitatory postsynaptic potential|positive regulation of establishment of endothelial barrier "hsa04071,hsa04080" Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction S1PR3 52.03075497 79.07145508 24.99005486 0.316043948 -1.661802905 0.005771123 0.458837827 0.97457234 0.302853598 1903 sphingosine-1-phosphate receptor 3 "GO:0003376,GO:0004930,GO:0005178,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0006954,GO:0007186,GO:0007189,GO:0007193,GO:0007204,GO:0007219,GO:0008284,GO:0008289,GO:0009653,GO:0019222,GO:0032651,GO:0038036,GO:1903141" sphingosine-1-phosphate receptor signaling pathway|G protein-coupled receptor activity|integrin binding|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|inflammatory response|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|Notch signaling pathway|positive regulation of cell population proliferation|lipid binding|anatomical structure morphogenesis|regulation of metabolic process|regulation of interleukin-1 beta production|sphingosine-1-phosphate receptor activity|negative regulation of establishment of endothelial barrier "hsa04071,hsa04080" Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction S1PR5 59.3287434 56.18234966 62.47513714 1.112006485 0.153165201 0.812055914 1 1.20901159 1.321931534 53637 sphingosine-1-phosphate receptor 5 "GO:0003376,GO:0004930,GO:0005515,GO:0005737,GO:0005886,GO:0007186,GO:0007189,GO:0016021,GO:0019222,GO:0038036,GO:0045664" sphingosine-1-phosphate receptor signaling pathway|G protein-coupled receptor activity|protein binding|cytoplasm|plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|integral component of membrane|regulation of metabolic process|sphingosine-1-phosphate receptor activity|regulation of neuron differentiation "hsa04071,hsa04080" Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction SAA1 36.37988735 59.30359131 13.45618338 0.226903347 -2.139850202 0.002365094 0.313463325 5.466189418 1.219541991 6288 serum amyloid A1 "GO:0000187,GO:0001664,GO:0001819,GO:0005576,GO:0005881,GO:0006898,GO:0006953,GO:0007186,GO:0007204,GO:0008201,GO:0019221,GO:0030168,GO:0030593,GO:0032732,GO:0034364,GO:0044267,GO:0045087,GO:0045785,GO:0048246,GO:0048247,GO:0050708,GO:0050728,GO:0070062,GO:0071682" activation of MAPK activity|G protein-coupled receptor binding|positive regulation of cytokine production|extracellular region|cytoplasmic microtubule|receptor-mediated endocytosis|acute-phase response|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|heparin binding|cytokine-mediated signaling pathway|platelet activation|neutrophil chemotaxis|positive regulation of interleukin-1 production|high-density lipoprotein particle|cellular protein metabolic process|innate immune response|positive regulation of cell adhesion|macrophage chemotaxis|lymphocyte chemotaxis|regulation of protein secretion|negative regulation of inflammatory response|extracellular exosome|endocytic vesicle lumen SAA2 7.282897178 14.56579436 0 0 #NAME? 0.003608685 0.380284526 0.327857307 0 6289 serum amyloid A2 "GO:0005515,GO:0006953,GO:0034364,GO:0070062" protein binding|acute-phase response|high-density lipoprotein particle|extracellular exosome SAA4 2.080827765 4.161655531 0 0 #NAME? 0.234194363 1 0.352539535 0 6291 "serum amyloid A4, constitutive" "GO:0005515,GO:0005576,GO:0006953,GO:0034364,GO:0070062" protein binding|extracellular region|acute-phase response|high-density lipoprotein particle|extracellular exosome SAAL1 555.5846996 505.641147 605.5282523 1.197545445 0.260080405 0.331215893 1 17.15520578 20.2003602 113174 serum amyloid A like 1 "GO:0003674,GO:0005634,GO:0005654,GO:1901647" molecular_function|nucleus|nucleoplasm|positive regulation of synoviocyte proliferation SAC3D1 333.5538721 316.2858203 350.8219239 1.109192703 0.14951003 0.629552913 1 10.71720186 11.68852185 29901 SAC3 domain containing 1 "GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005819,GO:0051225,GO:0051298,GO:0051301" protein binding|nucleus|cytoplasm|centrosome|spindle|spindle assembly|centrosome duplication|cell division SACM1L 870.5098871 837.5331755 903.4865986 1.078747237 0.109356864 0.663724935 1 12.25263329 12.99631744 22908 SAC1 like phosphatidylinositide phosphatase "GO:0000139,GO:0004438,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0006661,GO:0016021,GO:0016791,GO:0034596,GO:0043812,GO:0046856,GO:0140268" Golgi membrane|phosphatidylinositol-3-phosphatase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|phosphatidylinositol biosynthetic process|integral component of membrane|phosphatase activity|phosphatidylinositol phosphate 4-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity|phosphatidylinositol dephosphorylation|endoplasmic reticulum-plasma membrane contact site "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system SACS 3822.918519 4073.220351 3572.616688 0.877098802 -0.189188729 0.42650803 1 13.62031854 11.74645883 26278 sacsin molecular chaperone "GO:0005634,GO:0005737,GO:0005739,GO:0006457,GO:0030424,GO:0030425,GO:0030544,GO:0051087,GO:0070628,GO:0070852,GO:0090084" nucleus|cytoplasm|mitochondrion|protein folding|axon|dendrite|Hsp70 protein binding|chaperone binding|proteasome binding|cell body fiber|negative regulation of inclusion body assembly SAE1 3492.681461 3377.183463 3608.179459 1.068399007 0.09545054 0.688239124 1 71.46474006 75.07519566 10055 SUMO1 activating enzyme subunit 1 "GO:0004839,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008022,GO:0008047,GO:0016567,GO:0016925,GO:0018215,GO:0019948,GO:0031510,GO:0032446,GO:0033235,GO:0043008,GO:0044388,GO:0046982,GO:0050790,GO:1903955" ubiquitin activating enzyme activity|protein binding|nucleus|nucleoplasm|cytoplasm|protein C-terminus binding|enzyme activator activity|protein ubiquitination|protein sumoylation|protein phosphopantetheinylation|SUMO activating enzyme activity|SUMO activating enzyme complex|protein modification by small protein conjugation|positive regulation of protein sumoylation|ATP-dependent protein binding|small protein activating enzyme binding|protein heterodimerization activity|regulation of catalytic activity|positive regulation of protein targeting to mitochondrion hsa04120 Ubiquitin mediated proteolysis SAFB 1407.153286 1438.8924 1375.414173 0.955883966 -0.065092594 0.788140163 1 25.04600222 23.54045051 6294 scaffold attachment factor B "GO:0000978,GO:0003682,GO:0003690,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0006357,GO:0030496,GO:0030520,GO:0043565,GO:0050684" RNA polymerase II cis-regulatory region sequence-specific DNA binding|chromatin binding|double-stranded DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|chromatin organization|regulation of transcription by RNA polymerase II|midbody|intracellular estrogen receptor signaling pathway|sequence-specific DNA binding|regulation of mRNA processing SAFB2 551.9822656 600.3188103 503.6457209 0.838963751 -0.253319617 0.344497494 1 9.070756389 7.482692162 9667 scaffold attachment factor B2 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0016604,GO:0042802,GO:0043231,GO:0043565,GO:0050684,GO:0060008,GO:0060765,GO:0070062" RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|nuclear body|identical protein binding|intracellular membrane-bounded organelle|sequence-specific DNA binding|regulation of mRNA processing|Sertoli cell differentiation|regulation of androgen receptor signaling pathway|extracellular exosome SALL2 194.4296771 209.1231904 179.7361638 0.859475046 -0.218472341 0.558730547 1 2.173845018 1.83710098 6297 spalt like transcription factor 2 "GO:0000122,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001654,GO:0005515,GO:0005634,GO:0006357,GO:0021915,GO:0044877,GO:0045944,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|eye development|protein binding|nucleus|regulation of transcription by RNA polymerase II|neural tube development|protein-containing complex binding|positive regulation of transcription by RNA polymerase II|metal ion binding" SALL4 269.2507723 280.9117483 257.5897962 0.916977655 -0.125041517 0.710170683 1 2.309975919 2.082751155 57167 spalt like transcription factor 4 "GO:0000122,GO:0000792,GO:0000978,GO:0000981,GO:0001833,GO:0001843,GO:0003281,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0008134,GO:0030326,GO:0032991,GO:0035019,GO:0043231,GO:0045944,GO:0046872" "negative regulation of transcription by RNA polymerase II|heterochromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|inner cell mass cell proliferation|neural tube closure|ventricular septum development|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|transcription factor binding|embryonic limb morphogenesis|protein-containing complex|somatic stem cell population maintenance|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 SAMD1 522.2858106 552.4597717 492.1118495 0.890765038 -0.166883161 0.540560315 1 13.42612142 11.75939319 90378 sterile alpha motif domain containing 1 "GO:0003682,GO:0005576,GO:0005634,GO:0005737,GO:0042393,GO:0045892" "chromatin binding|extracellular region|nucleus|cytoplasm|histone binding|negative regulation of transcription, DNA-templated" SAMD10 78.9827507 80.11186896 77.85363244 0.971811461 -0.041251648 0.962668412 1 1.32243217 1.263649416 140700 sterile alpha motif domain containing 10 SAMD11 61.17179739 54.1015219 68.24207288 1.261370669 0.334992291 0.562108763 1 0.805158614 0.998608711 148398 sterile alpha motif domain containing 11 "GO:0003682,GO:0005515,GO:0005634,GO:0042393,GO:0045892" "chromatin binding|protein binding|nucleus|histone binding|negative regulation of transcription, DNA-templated" SAMD12 457.6361109 482.7520415 432.5201802 0.895946869 -0.158514914 0.574092037 1 2.352409532 2.072365555 401474 sterile alpha motif domain containing 12 "GO:0003674,GO:0005515,GO:0005575,GO:0008150" molecular_function|protein binding|cellular_component|biological_process SAMD13 17.97449958 17.687036 18.26196316 1.032505568 0.046149562 1 1 0.569658783 0.578333539 148418 sterile alpha motif domain containing 13 "GO:0003682,GO:0005634,GO:0042393,GO:0045892" "chromatin binding|nucleus|histone binding|negative regulation of transcription, DNA-templated" SAMD14 124.5929992 91.55642167 157.6295768 1.721665984 0.783805276 0.070946139 1 0.740108748 1.252897708 201191 sterile alpha motif domain containing 14 "GO:0005737,GO:0007015,GO:0014069,GO:0015629,GO:0019722,GO:0030425,GO:0031175,GO:0051015" cytoplasm|actin filament organization|postsynaptic density|actin cytoskeleton|calcium-mediated signaling|dendrite|neuron projection development|actin filament binding SAMD15 27.02119282 28.09117483 25.95121081 0.923820772 -0.11431511 0.930963103 1 0.706491221 0.641749695 161394 sterile alpha motif domain containing 15 SAMD4A 1303.076685 1318.204389 1287.948981 0.977048014 -0.033498634 0.89242158 1 9.174510368 8.813937789 23034 sterile alpha motif domain containing 4A "GO:0000289,GO:0000932,GO:0001650,GO:0003723,GO:0003729,GO:0005515,GO:0005829,GO:0017148,GO:0030054,GO:0030371,GO:0030425,GO:0043488,GO:0045202,GO:0045727" nuclear-transcribed mRNA poly(A) tail shortening|P-body|fibrillar center|RNA binding|mRNA binding|protein binding|cytosol|negative regulation of translation|cell junction|translation repressor activity|dendrite|regulation of mRNA stability|synapse|positive regulation of translation SAMD4B 1841.949367 1952.856858 1731.041877 0.886415136 -0.173945579 0.46347748 1 9.214073141 8.030821945 55095 sterile alpha motif domain containing 4B "GO:0000289,GO:0000932,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005829,GO:0017148,GO:0030371,GO:0043488" nuclear-transcribed mRNA poly(A) tail shortening|P-body|RNA binding|mRNA binding|protein binding|nucleus|cytosol|negative regulation of translation|translation repressor activity|regulation of mRNA stability SAMD5 9.566900179 11.44455271 7.689247648 0.671869652 -0.573746729 0.681462136 1 0.085470857 0.056464341 389432 sterile alpha motif domain containing 5 GO:0005737 cytoplasm SAMD8 2369.418354 2363.820341 2375.016367 1.004736412 0.006817066 0.978995071 1 18.53007449 18.3062962 142891 sterile alpha motif domain containing 8 "GO:0002950,GO:0003674,GO:0005783,GO:0005789,GO:0005829,GO:0005887,GO:0006686,GO:0016021,GO:0030148,GO:0030173,GO:0030176,GO:0033188,GO:0046513,GO:0047493,GO:2000303" ceramide phosphoethanolamine synthase activity|molecular_function|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|integral component of plasma membrane|sphingomyelin biosynthetic process|integral component of membrane|sphingolipid biosynthetic process|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|sphingomyelin synthase activity|ceramide biosynthetic process|ceramide cholinephosphotransferase activity|regulation of ceramide biosynthetic process SAMD9 919.5382873 913.483389 925.5931856 1.013256723 0.018999748 0.943602634 1 7.162934111 7.136440168 54809 sterile alpha motif domain containing 9 "GO:0005515,GO:0005737,GO:0005829,GO:0034058,GO:0043231" protein binding|cytoplasm|cytosol|endosomal vesicle fusion|intracellular membrane-bounded organelle SAMD9L 312.1209775 333.9728563 290.2690987 0.869139791 -0.202339858 0.519323254 1 2.492799654 2.130336399 219285 sterile alpha motif domain containing 9 like "GO:0005515,GO:0005737,GO:0005769" protein binding|cytoplasm|early endosome SAMHD1 1810.940126 1883.149128 1738.731124 0.923310374 -0.115112399 0.628450179 1 16.83984716 15.28822406 25939 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 "GO:0000724,GO:0003676,GO:0003697,GO:0003723,GO:0004540,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005886,GO:0006203,GO:0006955,GO:0006974,GO:0008270,GO:0008832,GO:0009264,GO:0016032,GO:0016446,GO:0016793,GO:0032567,GO:0035861,GO:0042802,GO:0045088,GO:0046061,GO:0051289,GO:0051607,GO:0060337,GO:0060339,GO:0090501,GO:0097197,GO:0110025" double-strand break repair via homologous recombination|nucleic acid binding|single-stranded DNA binding|RNA binding|ribonuclease activity|protein binding|GTP binding|nucleus|nucleoplasm|plasma membrane|dGTP catabolic process|immune response|cellular response to DNA damage stimulus|zinc ion binding|dGTPase activity|deoxyribonucleotide catabolic process|viral process|somatic hypermutation of immunoglobulin genes|triphosphoric monoester hydrolase activity|dGTP binding|site of double-strand break|identical protein binding|regulation of innate immune response|dATP catabolic process|protein homotetramerization|defense response to virus|type I interferon signaling pathway|negative regulation of type I interferon-mediated signaling pathway|RNA phosphodiester bond hydrolysis|tetraspanin-enriched microdomain|DNA strand resection involved in replication fork processing hsa05170 Human immunodeficiency virus 1 infection SAMM50 938.2066009 898.9175946 977.4956072 1.087414033 0.120901352 0.627396887 1 28.3531796 30.31571956 25813 SAMM50 sorting and assembly machinery component "GO:0001401,GO:0005515,GO:0005739,GO:0005741,GO:0007007,GO:0016021,GO:0033108,GO:0034622,GO:0042407,GO:0045040,GO:0070062,GO:0140275" SAM complex|protein binding|mitochondrion|mitochondrial outer membrane|inner mitochondrial membrane organization|integral component of membrane|mitochondrial respiratory chain complex assembly|cellular protein-containing complex assembly|cristae formation|protein insertion into mitochondrial outer membrane|extracellular exosome|MIB complex SAMSN1 9.487642252 9.363724944 9.61155956 1.026467524 0.037687984 1 1 0.135757889 0.137019213 64092 "SAM domain, SH3 domain and nuclear localization signals 1" "GO:0001726,GO:0001784,GO:0002820,GO:0003723,GO:0005634,GO:0005737,GO:0050732,GO:0050869" ruffle|phosphotyrosine residue binding|negative regulation of adaptive immune response|RNA binding|nucleus|cytoplasm|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of B cell activation SAP130 1387.261505 1408.720397 1365.802613 0.969534207 -0.044636294 0.855016196 1 17.37882998 16.56741875 79595 Sin3A associated protein 130 "GO:0000122,GO:0016607,GO:0070822" negative regulation of transcription by RNA polymerase II|nuclear speck|Sin3-type complex SAP18 2170.510604 2037.130382 2303.890827 1.130949127 0.177534034 0.453185217 1 43.64428118 48.53349793 10284 Sin3A associated protein 18 "GO:0000118,GO:0000381,GO:0003714,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006397,GO:0008134,GO:0008380,GO:0016604,GO:0016607,GO:0035145,GO:0043065,GO:0045892,GO:0048025,GO:0061574" "histone deacetylase complex|regulation of alternative mRNA splicing, via spliceosome|transcription corepressor activity|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|mRNA processing|transcription factor binding|RNA splicing|nuclear body|nuclear speck|exon-exon junction complex|positive regulation of apoptotic process|negative regulation of transcription, DNA-templated|negative regulation of mRNA splicing, via spliceosome|ASAP complex" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway SAP25 5.925451589 4.161655531 7.689247648 1.847641543 0.88568489 0.619277139 1 0.169931069 0.308717811 100316904 Sin3A associated protein 25 "GO:0005634,GO:0005737,GO:0006355" "nucleus|cytoplasm|regulation of transcription, DNA-templated" SAP30 208.5299847 200.7998793 216.2600901 1.076993128 0.107009044 0.776039267 1 9.768751601 10.34482569 8819 Sin3A associated protein 30 "GO:0000118,GO:0000122,GO:0003677,GO:0003712,GO:0003714,GO:0005515,GO:0005654,GO:0006355,GO:0035914,GO:0046872" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|DNA binding|transcription coregulator activity|transcription corepressor activity|protein binding|nucleoplasm|regulation of transcription, DNA-templated|skeletal muscle cell differentiation|metal ion binding" hsa05169 Epstein-Barr virus infection other SAP30BP 1619.449251 1536.691305 1702.207198 1.107709267 0.147579276 0.535986267 1 25.97731727 28.29379913 29115 SAP30 binding protein "GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006915,GO:0010942,GO:0045111" "protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|apoptotic process|positive regulation of cell death|intermediate filament cytoskeleton" SAP30L 478.6330869 453.6204528 503.6457209 1.11028001 0.150923567 0.588766618 1 3.914129321 4.273058806 79685 SAP30 like "GO:0000118,GO:0001650,GO:0003677,GO:0003712,GO:0005515,GO:0005654,GO:0005730,GO:0006355,GO:0008270,GO:0010314,GO:0031491,GO:0042393,GO:0044378" "histone deacetylase complex|fibrillar center|DNA binding|transcription coregulator activity|protein binding|nucleoplasm|nucleolus|regulation of transcription, DNA-templated|zinc ion binding|phosphatidylinositol-5-phosphate binding|nucleosome binding|histone binding|non-sequence-specific DNA binding, bending" hsa05169 Epstein-Barr virus infection SAPCD1 78.02159474 80.11186896 75.93132052 0.947816116 -0.077320902 0.905091683 1 4.672593669 4.354650291 401251 suppressor APC domain containing 1 SAPCD2 595.7287241 764.7042037 426.7532445 0.55806316 -0.841499683 0.001444349 0.240871566 10.45360089 5.736149316 89958 suppressor APC domain containing 2 "GO:0000132,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0005923,GO:0008284,GO:0016324,GO:0043296,GO:0045179,GO:0090175,GO:0098725,GO:1904777" establishment of mitotic spindle orientation|protein binding|nucleoplasm|nucleolus|cytosol|bicellular tight junction|positive regulation of cell population proliferation|apical plasma membrane|apical junction complex|apical cortex|regulation of establishment of planar polarity|symmetric cell division|negative regulation of protein localization to cell cortex SAR1A 3879.593236 3062.97847 4696.208001 1.533216131 0.616561082 0.009755838 0.604180798 27.3719912 41.26491456 56681 secretion associated Ras related GTPase 1A "GO:0000139,GO:0003400,GO:0003924,GO:0005515,GO:0005525,GO:0006886,GO:0006888,GO:0016050,GO:0030127,GO:0061024,GO:0070863,GO:0070971,GO:0090110" Golgi membrane|regulation of COPII vesicle coating|GTPase activity|protein binding|GTP binding|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|vesicle organization|COPII vesicle coat|membrane organization|positive regulation of protein exit from endoplasmic reticulum|endoplasmic reticulum exit site|COPII-coated vesicle cargo loading "hsa04141,hsa05134" Protein processing in endoplasmic reticulum|Legionellosis SAR1B 994.7512561 907.2409057 1082.261606 1.192915354 0.254491677 0.301257952 1 7.296229611 8.558138288 51128 secretion associated Ras related GTPase 1B "GO:0002474,GO:0003400,GO:0003924,GO:0005515,GO:0005525,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0012507,GO:0016050,GO:0019886,GO:0030127,GO:0032580,GO:0046872,GO:0048208,GO:0061024,GO:0070863,GO:0070971" antigen processing and presentation of peptide antigen via MHC class I|regulation of COPII vesicle coating|GTPase activity|protein binding|GTP binding|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|ER to Golgi transport vesicle membrane|vesicle organization|antigen processing and presentation of exogenous peptide antigen via MHC class II|COPII vesicle coat|Golgi cisterna membrane|metal ion binding|COPII vesicle coating|membrane organization|positive regulation of protein exit from endoplasmic reticulum|endoplasmic reticulum exit site "hsa04141,hsa05134" Protein processing in endoplasmic reticulum|Legionellosis SARAF 2064.813632 1962.220583 2167.406681 1.104568314 0.143482648 0.544882347 1 32.92049861 35.7544551 51669 store-operated calcium entry associated regulatory factor "GO:0005515,GO:0005783,GO:0006816,GO:0030176,GO:0140268,GO:2001256" protein binding|endoplasmic reticulum|calcium ion transport|integral component of endoplasmic reticulum membrane|endoplasmic reticulum-plasma membrane contact site|regulation of store-operated calcium entry SARDH 79.98353562 81.15228285 78.81478839 0.971196196 -0.042165324 0.960653684 1 0.98902676 0.944465708 1757 sarcosine dehydrogenase "GO:0005737,GO:0005739,GO:0005759,GO:0008480,GO:0016491,GO:0042426,GO:0055114,GO:1901053" cytoplasm|mitochondrion|mitochondrial matrix|sarcosine dehydrogenase activity|oxidoreductase activity|choline catabolic process|oxidation-reduction process|sarcosine catabolic process hsa00260 "Glycine, serine and threonine metabolism" SARM1 404.2328191 430.7313474 377.7342907 0.876960298 -0.189416565 0.514757393 1 2.236775359 1.928739081 23098 sterile alpha and TIR motif containing 1 "GO:0003953,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0005874,GO:0007165,GO:0007399,GO:0009749,GO:0019677,GO:0030154,GO:0030424,GO:0030425,GO:0031315,GO:0034128,GO:0035591,GO:0042981,GO:0045087,GO:0045202,GO:0048678,GO:0048814,GO:0050135,GO:0061809,GO:1901214,GO:1901216" "NAD+ nucleosidase activity|protein binding|cytoplasm|mitochondrion|cytosol|microtubule|signal transduction|nervous system development|response to glucose|NAD catabolic process|cell differentiation|axon|dendrite|extrinsic component of mitochondrial outer membrane|negative regulation of MyD88-independent toll-like receptor signaling pathway|signaling adaptor activity|regulation of apoptotic process|innate immune response|synapse|response to axon injury|regulation of dendrite morphogenesis|NAD(P)+ nucleosidase activity|NAD+ nucleotidase, cyclic ADP-ribose generating|regulation of neuron death|positive regulation of neuron death" SARNP 1039.915525 932.2108388 1147.620211 1.231073662 0.299917089 0.221038456 1 55.40131307 67.06181091 84324 SAP domain containing ribonucleoprotein "GO:0000346,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006405,GO:0006406,GO:0006417,GO:0016607,GO:0016973,GO:0031124,GO:0036464" transcription export complex|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|RNA export from nucleus|mRNA export from nucleus|regulation of translation|nuclear speck|poly(A)+ mRNA export from nucleus|mRNA 3'-end processing|cytoplasmic ribonucleoprotein granule SARS1 6088.259044 6518.192975 5658.325113 0.868081865 -0.204096992 0.399784149 1 173.498244 148.0904134 6301 seryl-tRNA synthetase 1 "GO:0000049,GO:0000122,GO:0000978,GO:0003723,GO:0004828,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006412,GO:0006418,GO:0006434,GO:0008033,GO:0016259,GO:0016525,GO:0019899,GO:0042803,GO:0070062,GO:0097056,GO:1904046" tRNA binding|negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA binding|serine-tRNA ligase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|translation|tRNA aminoacylation for protein translation|seryl-tRNA aminoacylation|tRNA processing|selenocysteine metabolic process|negative regulation of angiogenesis|enzyme binding|protein homodimerization activity|extracellular exosome|selenocysteinyl-tRNA(Sec) biosynthetic process|negative regulation of vascular endothelial growth factor production hsa00970 Aminoacyl-tRNA biosynthesis SARS2 149.7560468 159.183324 140.3287696 0.881554462 -0.181878394 0.664622348 1 4.401720952 3.81542423 54938 "seryl-tRNA synthetase 2, mitochondrial" "GO:0000049,GO:0003723,GO:0004828,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0006418,GO:0006434,GO:0070158,GO:0097056" tRNA binding|RNA binding|serine-tRNA ligase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|tRNA aminoacylation for protein translation|seryl-tRNA aminoacylation|mitochondrial seryl-tRNA aminoacylation|selenocysteinyl-tRNA(Sec) biosynthetic process hsa00970 Aminoacyl-tRNA biosynthesis SART1 1558.84232 1472.185644 1645.498997 1.117725202 0.160565539 0.501230315 1 29.85100382 32.80689752 9092 "spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP" "GO:0000387,GO:0000398,GO:0000481,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0015030,GO:0016607,GO:0045292,GO:0045585,GO:0046540,GO:0071005,GO:0071013" "spliceosomal snRNP assembly|mRNA splicing, via spliceosome|maturation of 5S rRNA|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|Cajal body|nuclear speck|mRNA cis splicing, via spliceosome|positive regulation of cytotoxic T cell differentiation|U4/U6 x U5 tri-snRNP complex|U2-type precatalytic spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SART3 1553.248377 1539.812546 1566.684208 1.017451255 0.024959679 0.919355295 1 19.43636839 19.44464024 9733 "spliceosome associated factor 3, U4/U6 recycling protein" "GO:0000244,GO:0000387,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005691,GO:0005737,GO:0006334,GO:0010468,GO:0015030,GO:0016607,GO:0017070,GO:0030621,GO:0030624,GO:0042393,GO:0046540,GO:0061574,GO:0071001,GO:0071002,GO:1903586,GO:1990381" "spliceosomal tri-snRNP complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U6atac snRNP|cytoplasm|nucleosome assembly|regulation of gene expression|Cajal body|nuclear speck|U6 snRNA binding|U4 snRNA binding|U6atac snRNA binding|histone binding|U4/U6 x U5 tri-snRNP complex|ASAP complex|U4/U6 snRNP|U4atac/U6atac snRNP|positive regulation of histone deubiquitination|ubiquitin-specific protease binding" SASH1 1152.240596 1155.899824 1148.581367 0.993668607 -0.009163308 0.973885778 1 5.602929077 5.474290915 23328 SAM and SH3 domain containing 1 "GO:0000209,GO:0001965,GO:0005515,GO:0005737,GO:0008022,GO:0010595,GO:0010632,GO:0019901,GO:0031435,GO:0031666,GO:0032991,GO:0043507,GO:0045766,GO:0060090,GO:1900044,GO:1900745,GO:1901224,GO:1902498" protein polyubiquitination|G-protein alpha-subunit binding|protein binding|cytoplasm|protein C-terminus binding|positive regulation of endothelial cell migration|regulation of epithelial cell migration|protein kinase binding|mitogen-activated protein kinase kinase kinase binding|positive regulation of lipopolysaccharide-mediated signaling pathway|protein-containing complex|positive regulation of JUN kinase activity|positive regulation of angiogenesis|molecular adaptor activity|regulation of protein K63-linked ubiquitination|positive regulation of p38MAPK cascade|positive regulation of NIK/NF-kappaB signaling|regulation of protein autoubiquitination SASS6 423.4062484 454.6608667 392.15163 0.862514588 -0.213379237 0.456373124 1 4.953943411 4.201348126 163786 SAS-6 centriolar assembly protein "GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0007099,GO:0034451,GO:0051298,GO:0098536" protein binding|centrosome|centriole|cytosol|centriole replication|centriolar satellite|centrosome duplication|deuterosome SAT1 4626.062971 3331.405252 5920.720689 1.777244208 0.829641933 0.000566906 0.133662814 71.31607519 124.6251575 6303 spermidine/spermine N1-acetyltransferase 1 "GO:0001525,GO:0004145,GO:0005515,GO:0005829,GO:0006596,GO:0008080,GO:0009447,GO:0019809,GO:0032918,GO:0042802" angiogenesis|diamine N-acetyltransferase activity|protein binding|cytosol|polyamine biosynthetic process|N-acetyltransferase activity|putrescine catabolic process|spermidine binding|spermidine acetylation|identical protein binding "hsa00330,hsa04216" Arginine and proline metabolism|Ferroptosis SAT2 668.6532738 673.1477821 664.1587656 0.986646296 -0.019395112 0.946326993 1 34.87831062 33.83670845 112483 spermidine/spermine N1-acetyltransferase family member 2 "GO:0004145,GO:0005515,GO:0005737,GO:0006596,GO:0008080,GO:0019809,GO:0032918,GO:0032919,GO:0032920,GO:0042802,GO:0046204,GO:0070062" diamine N-acetyltransferase activity|protein binding|cytoplasm|polyamine biosynthetic process|N-acetyltransferase activity|spermidine binding|spermidine acetylation|spermine acetylation|putrescine acetylation|identical protein binding|nor-spermidine metabolic process|extracellular exosome "hsa00330,hsa04216" Arginine and proline metabolism|Ferroptosis SATB1 483.1664943 433.8525891 532.4803996 1.227330234 0.295523483 0.284359996 1 2.188667671 2.641267784 6304 SATB homeobox 1 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0003690,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0006338,GO:0006357,GO:0016032,GO:0016363,GO:0016604,GO:0016605,GO:0043565" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|double-stranded DNA binding|protein binding|nucleus|nucleoplasm|chromatin organization|chromatin remodeling|regulation of transcription by RNA polymerase II|viral process|nuclear matrix|nuclear body|PML body|sequence-specific DNA binding" SATB2 441.6386434 428.6505196 454.6267672 1.060600061 0.084880736 0.769807104 1 3.46715526 3.615731029 23314 SATB homeobox 2 "GO:0000118,GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001764,GO:0002076,GO:0003682,GO:0005515,GO:0005654,GO:0005667,GO:0006338,GO:0006357,GO:0009880,GO:0016363,GO:0021902,GO:0042826,GO:0045944,GO:0048704,GO:0051216,GO:0060021,GO:0071310" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|neuron migration|osteoblast development|chromatin binding|protein binding|nucleoplasm|transcription regulator complex|chromatin remodeling|regulation of transcription by RNA polymerase II|embryonic pattern specification|nuclear matrix|commitment of neuronal cell to specific neuron type in forebrain|histone deacetylase binding|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|cartilage development|roof of mouth development|cellular response to organic substance" SATL1 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.074781113 0.033964156 340562 spermidine/spermine N1-acetyl transferase like 1 GO:0008080 N-acetyltransferase activity SAV1 1185.02811 1284.911145 1085.145074 0.844529272 -0.243780666 0.31479563 1 17.47536856 14.51149745 60485 salvador family WW domain containing protein 1 "GO:0001942,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0006915,GO:0007165,GO:0030159,GO:0030216,GO:0030425,GO:0031697,GO:0035329,GO:0042802,GO:0043065,GO:0043113,GO:0045600,GO:0046332,GO:0050680,GO:0050821,GO:0051091,GO:0060044,GO:0060412,GO:0060487,GO:0060575,GO:0070699,GO:2000036" hair follicle development|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|cell-cell junction|apoptotic process|signal transduction|signaling receptor complex adaptor activity|keratinocyte differentiation|dendrite|beta-1 adrenergic receptor binding|hippo signaling|identical protein binding|positive regulation of apoptotic process|receptor clustering|positive regulation of fat cell differentiation|SMAD binding|negative regulation of epithelial cell proliferation|protein stabilization|positive regulation of DNA-binding transcription factor activity|negative regulation of cardiac muscle cell proliferation|ventricular septum morphogenesis|lung epithelial cell differentiation|intestinal epithelial cell differentiation|type II activin receptor binding|regulation of stem cell population maintenance "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species SAXO2 18.9752845 18.72744989 19.22311912 1.026467524 0.037687984 1 1 0.258255706 0.260655154 283726 stabilizer of axonemal microtubules 2 "GO:0005515,GO:0005814,GO:0005856,GO:0005879,GO:0008017,GO:0034453,GO:0036064,GO:0036126" protein binding|centriole|cytoskeleton|axonemal microtubule|microtubule binding|microtubule anchoring|ciliary basal body|sperm flagellum SAYSD1 96.75407505 105.0818021 88.42634795 0.841500109 -0.248964637 0.61091668 1 0.872843992 0.72220748 55776 SAYSVFN motif domain containing 1 "GO:0016021,GO:0030659,GO:0043231" integral component of membrane|cytoplasmic vesicle membrane|intracellular membrane-bounded organelle SBDS 1273.108472 1149.65734 1396.559604 1.214761612 0.280673223 0.244417337 1 38.03787928 45.43374472 51119 SBDS ribosome maturation factor "GO:0000922,GO:0001833,GO:0002244,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0007052,GO:0008017,GO:0019843,GO:0030282,GO:0030595,GO:0042256,GO:0043022,GO:0048539" spindle pole|inner cell mass cell proliferation|hematopoietic progenitor cell differentiation|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|mitotic spindle organization|microtubule binding|rRNA binding|bone mineralization|leukocyte chemotaxis|mature ribosome assembly|ribosome binding|bone marrow development hsa03008 Ribosome biogenesis in eukaryotes SBF1 2891.848818 2756.056375 3027.641261 1.098541122 0.135588875 0.567195239 1 18.1520009 19.6070385 6305 SET binding factor 1 "GO:0005085,GO:0005737,GO:0005789,GO:0005829,GO:0006470,GO:0006661,GO:0007283,GO:0008138,GO:0016020,GO:0016021,GO:0016604,GO:0016791,GO:0019208,GO:0043087,GO:0048471" guanyl-nucleotide exchange factor activity|cytoplasm|endoplasmic reticulum membrane|cytosol|protein dephosphorylation|phosphatidylinositol biosynthetic process|spermatogenesis|protein tyrosine/serine/threonine phosphatase activity|membrane|integral component of membrane|nuclear body|phosphatase activity|phosphatase regulator activity|regulation of GTPase activity|perinuclear region of cytoplasm SBF2 1938.386411 2049.615349 1827.157472 0.891463598 -0.165752208 0.484413317 1 9.635676897 8.446115597 81846 SET binding factor 2 "GO:0005085,GO:0005515,GO:0005737,GO:0005829,GO:0006914,GO:0010008,GO:0016020,GO:0019208,GO:0030424,GO:0042552,GO:0043087,GO:0048471" guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|cytosol|autophagy|endosome membrane|membrane|phosphatase regulator activity|axon|myelination|regulation of GTPase activity|perinuclear region of cytoplasm SBK1 4.042768641 5.202069413 2.883467868 0.554292463 -0.851280704 0.745112452 1 0.047368177 0.025816468 388228 SH3 domain binding kinase 1 "GO:0004674,GO:0005524,GO:0005737,GO:0018105,GO:0018107,GO:0106310,GO:0106311" protein serine/threonine kinase activity|ATP binding|cytoplasm|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein serine kinase activity|protein threonine kinase activity SBK2 7.887392465 5.202069413 10.57271552 2.032405698 1.023188414 0.464422034 1 0.100334255 0.200507588 646643 SH3 domain binding kinase family member 2 "GO:0000165,GO:0000187,GO:0004708,GO:0005524,GO:0006468,GO:0106310,GO:0106311" MAPK cascade|activation of MAPK activity|MAP kinase kinase activity|ATP binding|protein phosphorylation|protein serine kinase activity|protein threonine kinase activity SBNO1 1376.792585 1449.296539 1304.288632 0.899946007 -0.152089647 0.526967828 1 6.950601417 6.150494257 55206 strawberry notch homolog 1 "GO:0003674,GO:0005575,GO:0005634,GO:0006355,GO:0008150,GO:0031490,GO:0042393" "molecular_function|cellular_component|nucleus|regulation of transcription, DNA-templated|biological_process|chromatin DNA binding|histone binding" SBNO2 2691.810107 2652.014987 2731.605227 1.030011233 0.042660071 0.858262128 1 28.08755024 28.44637965 22904 strawberry notch homolog 2 "GO:0002281,GO:0005575,GO:0005634,GO:0006355,GO:0030282,GO:0030316,GO:0031490,GO:0042393,GO:0045892,GO:0045944,GO:0050727,GO:0061430,GO:0071222,GO:0071348,GO:0071354,GO:0072675,GO:1990830" "macrophage activation involved in immune response|cellular_component|nucleus|regulation of transcription, DNA-templated|bone mineralization|osteoclast differentiation|chromatin DNA binding|histone binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of inflammatory response|bone trabecula morphogenesis|cellular response to lipopolysaccharide|cellular response to interleukin-11|cellular response to interleukin-6|osteoclast fusion|cellular response to leukemia inhibitory factor" SBSN 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.1107178 0.050285915 374897 suprabasin "GO:0003674,GO:0008150,GO:0070062" molecular_function|biological_process|extracellular exosome SC5D 782.7628763 741.8150983 823.7106543 1.11039888 0.151078018 0.551670039 1 5.590920548 6.104266899 6309 sterol-C5-desaturase "GO:0000248,GO:0005506,GO:0005789,GO:0006629,GO:0016020,GO:0016021,GO:0016126,GO:0016491,GO:0033489,GO:0033490,GO:0045540,GO:0055114" C-5 sterol desaturase activity|iron ion binding|endoplasmic reticulum membrane|lipid metabolic process|membrane|integral component of membrane|sterol biosynthetic process|oxidoreductase activity|cholesterol biosynthetic process via desmosterol|cholesterol biosynthetic process via lathosterol|regulation of cholesterol biosynthetic process|oxidation-reduction process hsa00100 Steroid biosynthesis SCAF1 1454.96828 1445.134883 1464.801677 1.013608968 0.019501194 0.938024532 1 16.40591207 16.3509128 58506 SR-related CTD associated factor 1 "GO:0003723,GO:0005515,GO:0005634,GO:0006366,GO:0006397,GO:0008380,GO:0019904,GO:0099122" RNA binding|protein binding|nucleus|transcription by RNA polymerase II|mRNA processing|RNA splicing|protein domain specific binding|RNA polymerase II C-terminal domain binding SCAF11 2166.43078 2422.083519 1910.778041 0.788898494 -0.342088411 0.147942153 1 13.82926563 10.72732464 9169 SR-related CTD associated factor 11 "GO:0000245,GO:0000375,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006397,GO:0008380,GO:0016604,GO:0046872" "spliceosomal complex assembly|RNA splicing, via transesterification reactions|RNA binding|protein binding|nucleoplasm|nucleolus|mRNA processing|RNA splicing|nuclear body|metal ion binding" SCAF4 628.6067858 668.9861265 588.2274451 0.879281979 -0.185602195 0.478629264 1 5.70328435 4.930879343 57466 SR-related CTD associated factor 4 "GO:0003723,GO:0005634,GO:0005654,GO:0006397,GO:0008022,GO:1990269,GO:2000805" "RNA binding|nucleus|nucleoplasm|mRNA processing|protein C-terminus binding|RNA polymerase II C-terminal domain phosphoserine binding|negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled" SCAF8 948.2830328 1037.292641 859.2734247 0.828380913 -0.271633783 0.271770418 1 11.2129637 9.133172876 22828 SR-related CTD associated factor 8 "GO:0000993,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005849,GO:0006369,GO:0006378,GO:0016363,GO:0032786,GO:0043175,GO:1990269,GO:2000805" "RNA polymerase II complex binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|mRNA cleavage factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|nuclear matrix|positive regulation of DNA-templated transcription, elongation|RNA polymerase core enzyme binding|RNA polymerase II C-terminal domain phosphoserine binding|negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled" SCAI 422.0242651 405.7614142 438.2871159 1.080159672 0.111244591 0.702332491 1 1.777893343 1.888273251 286205 suppressor of cancer cell invasion "GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0016021,GO:0030336,GO:0031965,GO:0035024,GO:0045892" "transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|integral component of membrane|negative regulation of cell migration|nuclear membrane|negative regulation of Rho protein signal transduction|negative regulation of transcription, DNA-templated" SCAMP1 2397.17299 2360.6991 2433.646881 1.030900923 0.043905686 0.85423372 1 20.22249955 20.49854055 9522 secretory carrier membrane protein 1 "GO:0005515,GO:0005802,GO:0005886,GO:0006892,GO:0015031,GO:0016021,GO:0030136,GO:0030672,GO:0032588,GO:0035579,GO:0042589,GO:0043312,GO:0055038" protein binding|trans-Golgi network|plasma membrane|post-Golgi vesicle-mediated transport|protein transport|integral component of membrane|clathrin-coated vesicle|synaptic vesicle membrane|trans-Golgi network membrane|specific granule membrane|zymogen granule membrane|neutrophil degranulation|recycling endosome membrane SCAMP2 1136.416121 1169.425204 1103.407037 0.943546482 -0.083834503 0.732899482 1 23.21803342 21.54070486 10066 secretory carrier membrane protein 2 "GO:0005515,GO:0005794,GO:0006892,GO:0015031,GO:0016021,GO:0030133,GO:0032588,GO:0043231,GO:0055038,GO:0070062" protein binding|Golgi apparatus|post-Golgi vesicle-mediated transport|protein transport|integral component of membrane|transport vesicle|trans-Golgi network membrane|intracellular membrane-bounded organelle|recycling endosome membrane|extracellular exosome SCAMP3 1103.053065 1176.708101 1029.398029 0.874811712 -0.192955559 0.429486431 1 40.64643927 34.96296647 10067 secretory carrier membrane protein 3 "GO:0006892,GO:0015031,GO:0016021,GO:0031625,GO:0032588,GO:0043231,GO:0055038,GO:0070062" post-Golgi vesicle-mediated transport|protein transport|integral component of membrane|ubiquitin protein ligase binding|trans-Golgi network membrane|intracellular membrane-bounded organelle|recycling endosome membrane|extracellular exosome SCAMP4 820.0888284 838.5735894 801.6040673 0.955913801 -0.065047565 0.799549964 1 17.89409486 16.81897967 113178 secretory carrier membrane protein 4 "GO:0005515,GO:0015031,GO:0016021,GO:0032588,GO:0055038" protein binding|protein transport|integral component of membrane|trans-Golgi network membrane|recycling endosome membrane SCAMP5 21.29891647 16.64662212 25.95121081 1.558947552 0.640572392 0.460049006 1 0.226055885 0.346512177 192683 secretory carrier membrane protein 5 "GO:0000139,GO:0001819,GO:0005515,GO:0005886,GO:0006887,GO:0015031,GO:0016021,GO:0030672,GO:0032588,GO:0034976,GO:0044877,GO:0045806,GO:0045956,GO:0055038" Golgi membrane|positive regulation of cytokine production|protein binding|plasma membrane|exocytosis|protein transport|integral component of membrane|synaptic vesicle membrane|trans-Golgi network membrane|response to endoplasmic reticulum stress|protein-containing complex binding|negative regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|recycling endosome membrane SCAND1 692.5783771 632.5716406 752.5851135 1.189723132 0.250625874 0.329666518 1 26.190214 30.63769803 51282 SCAN domain containing 1 "GO:0005515,GO:0005634,GO:0045893" "protein binding|nucleus|positive regulation of transcription, DNA-templated" SCAP 1254.796205 1274.507006 1235.085403 0.969069136 -0.0453285 0.854036848 1 14.91297884 14.20987776 22937 SREBF chaperone "GO:0000139,GO:0001666,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0006955,GO:0007568,GO:0008203,GO:0012507,GO:0016021,GO:0032868,GO:0032933,GO:0032934,GO:0032991,GO:0042304,GO:0044255,GO:0044877,GO:0045541,GO:0045542,GO:0051082,GO:0090110" Golgi membrane|response to hypoxia|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|immune response|aging|cholesterol metabolic process|ER to Golgi transport vesicle membrane|integral component of membrane|response to insulin|SREBP signaling pathway|sterol binding|protein-containing complex|regulation of fatty acid biosynthetic process|cellular lipid metabolic process|protein-containing complex binding|negative regulation of cholesterol biosynthetic process|positive regulation of cholesterol biosynthetic process|unfolded protein binding|COPII-coated vesicle cargo loading SCAPER 405.9028803 361.0236173 450.7821434 1.248622311 0.32033715 0.267015092 1 1.323112685 1.624422898 49855 S-phase cyclin A associated protein in the ER "GO:0003676,GO:0005515,GO:0005654,GO:0005783,GO:0005829,GO:0008270,GO:0016607" nucleic acid binding|protein binding|nucleoplasm|endoplasmic reticulum|cytosol|zinc ion binding|nuclear speck SCARA3 7.367185523 4.161655531 10.57271552 2.540507122 1.345116509 0.341208165 1 0.028035838 0.070033388 51435 scavenger receptor class A member 3 "GO:0000139,GO:0005044,GO:0005515,GO:0005581,GO:0005615,GO:0005783,GO:0005789,GO:0006897,GO:0006979,GO:0009650,GO:0016021,GO:0034138,GO:0062023" Golgi membrane|scavenger receptor activity|protein binding|collagen trimer|extracellular space|endoplasmic reticulum|endoplasmic reticulum membrane|endocytosis|response to oxidative stress|UV protection|integral component of membrane|toll-like receptor 3 signaling pathway|collagen-containing extracellular matrix SCARB1 694.1729821 750.1384094 638.2075548 0.850786397 -0.233131128 0.364442546 1 8.888434328 7.435616529 949 scavenger receptor class B member 1 "GO:0001530,GO:0001540,GO:0001618,GO:0001786,GO:0001875,GO:0001935,GO:0005044,GO:0005215,GO:0005515,GO:0005545,GO:0005737,GO:0005764,GO:0005765,GO:0005886,GO:0005887,GO:0005901,GO:0006702,GO:0006707,GO:0006898,GO:0008035,GO:0008289,GO:0009986,GO:0010595,GO:0010867,GO:0010886,GO:0010899,GO:0015914,GO:0015920,GO:0030169,GO:0030666,GO:0031528,GO:0031663,GO:0032497,GO:0033344,GO:0034185,GO:0034186,GO:0034375,GO:0034381,GO:0034383,GO:0034384,GO:0035461,GO:0042060,GO:0042632,GO:0042802,GO:0043231,GO:0043534,GO:0043654,GO:0043691,GO:0044406,GO:0046718,GO:0050764,GO:0050892,GO:0051000,GO:0070062,GO:0070328,GO:0070506,GO:0070508" lipopolysaccharide binding|amyloid-beta binding|virus receptor activity|phosphatidylserine binding|lipopolysaccharide immune receptor activity|endothelial cell proliferation|scavenger receptor activity|transporter activity|protein binding|1-phosphatidylinositol binding|cytoplasm|lysosome|lysosomal membrane|plasma membrane|integral component of plasma membrane|caveola|androgen biosynthetic process|cholesterol catabolic process|receptor-mediated endocytosis|high-density lipoprotein particle binding|lipid binding|cell surface|positive regulation of endothelial cell migration|positive regulation of triglyceride biosynthetic process|positive regulation of cholesterol storage|regulation of phosphatidylcholine catabolic process|phospholipid transport|lipopolysaccharide transport|low-density lipoprotein particle binding|endocytic vesicle membrane|microvillus membrane|lipopolysaccharide-mediated signaling pathway|detection of lipopolysaccharide|cholesterol efflux|apolipoprotein binding|apolipoprotein A-I binding|high-density lipoprotein particle remodeling|plasma lipoprotein particle clearance|low-density lipoprotein particle clearance|high-density lipoprotein particle clearance|vitamin transmembrane transport|wound healing|cholesterol homeostasis|identical protein binding|intracellular membrane-bounded organelle|blood vessel endothelial cell migration|recognition of apoptotic cell|reverse cholesterol transport|adhesion of symbiont to host|viral entry into host cell|regulation of phagocytosis|intestinal absorption|positive regulation of nitric-oxide synthase activity|extracellular exosome|triglyceride homeostasis|high-density lipoprotein particle receptor activity|cholesterol import "hsa04145,hsa04913,hsa04925,hsa04927,hsa04934,hsa04975,hsa04976,hsa04977,hsa04979,hsa05160" Phagosome|Ovarian steroidogenesis|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome|Fat digestion and absorption|Bile secretion|Vitamin digestion and absorption|Cholesterol metabolism|Hepatitis C SCARB2 5201.644706 5295.706663 5107.58275 0.964476146 -0.052182538 0.828823597 1 60.20923125 57.09863833 950 scavenger receptor class B member 2 "GO:0000139,GO:0001618,GO:0001786,GO:0004888,GO:0005044,GO:0005515,GO:0005737,GO:0005765,GO:0005789,GO:0005886,GO:0005925,GO:0006622,GO:0006898,GO:0010008,GO:0010976,GO:0015485,GO:0015917,GO:0016020,GO:0016021,GO:0019899,GO:0030665,GO:0030666,GO:0031210,GO:0031902,GO:0038024,GO:0042803,GO:0043202,GO:0043471,GO:0046718,GO:0061024,GO:0070062,GO:1904978,GO:1905123,GO:1905671" Golgi membrane|virus receptor activity|phosphatidylserine binding|transmembrane signaling receptor activity|scavenger receptor activity|protein binding|cytoplasm|lysosomal membrane|endoplasmic reticulum membrane|plasma membrane|focal adhesion|protein targeting to lysosome|receptor-mediated endocytosis|endosome membrane|positive regulation of neuron projection development|cholesterol binding|aminophospholipid transport|membrane|integral component of membrane|enzyme binding|clathrin-coated vesicle membrane|endocytic vesicle membrane|phosphatidylcholine binding|late endosome membrane|cargo receptor activity|protein homodimerization activity|lysosomal lumen|regulation of cellular carbohydrate catabolic process|viral entry into host cell|membrane organization|extracellular exosome|regulation of endosome organization|regulation of glucosylceramidase activity|regulation of lysosome organization hsa04142 Lysosome SCARF1 23.93958014 22.88910542 24.99005486 1.091788185 0.12669299 0.928499056 1 0.38030806 0.408267771 8578 scavenger receptor class F member 1 "GO:0004888,GO:0005044,GO:0005515,GO:0005886,GO:0006707,GO:0006898,GO:0007155,GO:0010976,GO:0016021,GO:0016322,GO:0016358,GO:0030169,GO:0030666,GO:0048680" transmembrane signaling receptor activity|scavenger receptor activity|protein binding|plasma membrane|cholesterol catabolic process|receptor-mediated endocytosis|cell adhesion|positive regulation of neuron projection development|integral component of membrane|neuron remodeling|dendrite development|low-density lipoprotein particle binding|endocytic vesicle membrane|positive regulation of axon regeneration SCARF2 423.6194845 422.4080364 424.8309325 1.005735914 0.008251532 0.986319273 1 6.362726657 6.292140385 91179 scavenger receptor class F member 2 "GO:0005044,GO:0005515,GO:0005925,GO:0006897,GO:0007157,GO:0016021" scavenger receptor activity|protein binding|focal adhesion|endocytosis|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|integral component of membrane SCCPDH 1357.783931 1215.203415 1500.364447 1.234661151 0.304115153 0.205148374 1 30.29106623 36.7733777 51097 saccharopine dehydrogenase (putative) "GO:0002576,GO:0005576,GO:0005634,GO:0005739,GO:0005811,GO:0005886,GO:0009247,GO:0016020,GO:0016491,GO:0030496,GO:0031093,GO:0055114" platelet degranulation|extracellular region|nucleus|mitochondrion|lipid droplet|plasma membrane|glycolipid biosynthetic process|membrane|oxidoreductase activity|midbody|platelet alpha granule lumen|oxidation-reduction process SCD 1688.604135 2153.656737 1223.551532 0.56812746 -0.815713458 0.000628679 0.143286309 21.91357518 12.24137487 6319 stearoyl-CoA desaturase "GO:0004768,GO:0005506,GO:0005515,GO:0005730,GO:0005783,GO:0005789,GO:0006636,GO:0016020,GO:0016021,GO:0016491,GO:0030176,GO:0032896,GO:0045540,GO:0046949,GO:0055114,GO:0070542,GO:0120162,GO:1903966" stearoyl-CoA 9-desaturase activity|iron ion binding|protein binding|nucleolus|endoplasmic reticulum|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|membrane|integral component of membrane|oxidoreductase activity|integral component of endoplasmic reticulum membrane|palmitoyl-CoA 9-desaturase activity|regulation of cholesterol biosynthetic process|fatty-acyl-CoA biosynthetic process|oxidation-reduction process|response to fatty acid|positive regulation of cold-induced thermogenesis|monounsaturated fatty acid biosynthetic process "hsa01040,hsa03320,hsa04152" Biosynthesis of unsaturated fatty acids|PPAR signaling pathway|AMPK signaling pathway SCD5 550.3228796 544.1364606 556.5092985 1.022738483 0.032437292 0.910519935 1 6.863522293 6.902125076 79966 stearoyl-CoA desaturase 5 "GO:0004768,GO:0005506,GO:0005789,GO:0006636,GO:0016021,GO:0016491,GO:0046949,GO:0055114,GO:1903966" stearoyl-CoA 9-desaturase activity|iron ion binding|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|integral component of membrane|oxidoreductase activity|fatty-acyl-CoA biosynthetic process|oxidation-reduction process|monounsaturated fatty acid biosynthetic process "hsa01040,hsa03320,hsa04152" Biosynthesis of unsaturated fatty acids|PPAR signaling pathway|AMPK signaling pathway SCFD1 1284.547994 1185.031412 1384.064577 1.167956024 0.223985955 0.352931162 1 24.79143414 28.47077703 23256 sec1 family domain containing 1 "GO:0000139,GO:0000902,GO:0001666,GO:0005515,GO:0005789,GO:0005798,GO:0005801,GO:0005829,GO:0005886,GO:0006886,GO:0006888,GO:0006890,GO:0006892,GO:0006904,GO:0009636,GO:0016192,GO:0019905,GO:0032580,GO:0044877,GO:0047485,GO:0048208,GO:0051223,GO:0060628,GO:1901998,GO:1902902" "Golgi membrane|cell morphogenesis|response to hypoxia|protein binding|endoplasmic reticulum membrane|Golgi-associated vesicle|cis-Golgi network|cytosol|plasma membrane|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|post-Golgi vesicle-mediated transport|vesicle docking involved in exocytosis|response to toxic substance|vesicle-mediated transport|syntaxin binding|Golgi cisterna membrane|protein-containing complex binding|protein N-terminus binding|COPII vesicle coating|regulation of protein transport|regulation of ER to Golgi vesicle-mediated transport|toxin transport|negative regulation of autophagosome assembly" SCFD2 260.1449428 218.4869154 301.8029702 1.381332011 0.466060121 0.158838831 1 1.064473718 1.44578661 152579 sec1 family domain containing 2 "GO:0003674,GO:0005575,GO:0005886,GO:0006886,GO:0006904,GO:0008150,GO:0016192,GO:0019905,GO:0030141" molecular_function|cellular_component|plasma membrane|intracellular protein transport|vesicle docking involved in exocytosis|biological_process|vesicle-mediated transport|syntaxin binding|secretory granule SCGB2B2 22.93879522 21.84869154 24.0288989 1.099786633 0.137223657 0.921166331 1 0.172412319 0.186443784 284402 secretoglobin family 2B member 2 "GO:0005515,GO:0005576" protein binding|extracellular region SCIN 2.40288989 0 4.80577978 Inf Inf 0.18976424 1 0 0.076165467 85477 scinderin "GO:0001786,GO:0002102,GO:0003779,GO:0005509,GO:0005545,GO:0005546,GO:0005737,GO:0005886,GO:0005938,GO:0007417,GO:0008154,GO:0008285,GO:0015629,GO:0017156,GO:0030031,GO:0030054,GO:0032330,GO:0032991,GO:0042989,GO:0042995,GO:0043065,GO:0045010,GO:0045654,GO:0051014,GO:0051015,GO:0051016,GO:0051047,GO:0051127,GO:0051693,GO:0070062" "phosphatidylserine binding|podosome|actin binding|calcium ion binding|1-phosphatidylinositol binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|plasma membrane|cell cortex|central nervous system development|actin polymerization or depolymerization|negative regulation of cell population proliferation|actin cytoskeleton|calcium-ion regulated exocytosis|cell projection assembly|cell junction|regulation of chondrocyte differentiation|protein-containing complex|sequestering of actin monomers|cell projection|positive regulation of apoptotic process|actin nucleation|positive regulation of megakaryocyte differentiation|actin filament severing|actin filament binding|barbed-end actin filament capping|positive regulation of secretion|positive regulation of actin nucleation|actin filament capping|extracellular exosome" "hsa04666,hsa04810,hsa05203" Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Viral carcinogenesis SCLT1 372.3467102 350.6194785 394.073942 1.12393625 0.168560208 0.572478663 1 2.310113229 2.552972428 132320 sodium channel and clathrin linker 1 "GO:0005813,GO:0005814,GO:0005829,GO:0008022,GO:0017080,GO:0030276,GO:0045162,GO:0060271,GO:0071439,GO:0097539,GO:0097711" centrosome|centriole|cytosol|protein C-terminus binding|sodium channel regulator activity|clathrin binding|clustering of voltage-gated sodium channels|cilium assembly|clathrin complex|ciliary transition fiber|ciliary basal body-plasma membrane docking SCLY 354.1734514 428.6505196 279.6963832 0.652504477 -0.615940294 0.039461635 1 9.337261391 5.99065337 51540 selenocysteine lyase "GO:0001887,GO:0005515,GO:0005794,GO:0005829,GO:0006520,GO:0009000,GO:0016740" selenium compound metabolic process|protein binding|Golgi apparatus|cytosol|cellular amino acid metabolic process|selenocysteine lyase activity|transferase activity hsa00450 Selenocompound metabolism SCMH1 688.1286436 742.8555122 633.401775 0.852658107 -0.229960719 0.371705011 1 10.26536338 8.606378298 22955 Scm polycomb group protein homolog 1 "GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006338,GO:0007283,GO:0009952,GO:0010369,GO:0016458,GO:0042393,GO:0045892" "chromatin binding|protein binding|nucleus|nucleoplasm|chromatin remodeling|spermatogenesis|anterior/posterior pattern specification|chromocenter|gene silencing|histone binding|negative regulation of transcription, DNA-templated" SCML1 1318.276543 1363.9826 1272.570486 0.932981466 -0.100079673 0.679194417 1 7.956415398 7.298971101 6322 Scm polycomb group protein like 1 "GO:0003682,GO:0005634,GO:0042393,GO:0045892" "chromatin binding|nucleus|histone binding|negative regulation of transcription, DNA-templated" SCML2 302.8119728 278.8309205 326.793025 1.172011427 0.228986636 0.469283947 1 3.385053176 3.900933258 10389 Scm polycomb group protein like 2 "GO:0003682,GO:0005515,GO:0005634,GO:0009653,GO:0031519,GO:0042393,GO:0045892" "chromatin binding|protein binding|nucleus|anatomical structure morphogenesis|PcG protein complex|histone binding|negative regulation of transcription, DNA-templated" SCN1A 13.85247302 10.40413883 17.30080721 1.662877389 0.733681797 0.488071191 1 0.041927793 0.068554097 6323 sodium voltage-gated channel alpha subunit 1 "GO:0001518,GO:0005244,GO:0005248,GO:0005654,GO:0005886,GO:0006814,GO:0016604,GO:0019228,GO:0030018,GO:0030424,GO:0034765,GO:0035725,GO:0050966,GO:0086002,GO:0086010" voltage-gated sodium channel complex|voltage-gated ion channel activity|voltage-gated sodium channel activity|nucleoplasm|plasma membrane|sodium ion transport|nuclear body|neuronal action potential|Z disc|axon|regulation of ion transmembrane transport|sodium ion transmembrane transport|detection of mechanical stimulus involved in sensory perception of pain|cardiac muscle cell action potential involved in contraction|membrane depolarization during action potential hsa04728 Dopaminergic synapse SCN1B 212.8551865 200.7998793 224.9104937 1.120072853 0.163592572 0.653455017 1 4.924779644 5.423807322 6324 sodium voltage-gated channel beta subunit 1 "GO:0001518,GO:0005244,GO:0005248,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0007155,GO:0007411,GO:0010765,GO:0010976,GO:0014704,GO:0017080,GO:0019227,GO:0019871,GO:0021966,GO:0030315,GO:0033268,GO:0035725,GO:0040011,GO:0043204,GO:0044325,GO:0046684,GO:0051899,GO:0060048,GO:0060307,GO:0060371,GO:0061337,GO:0086002,GO:0086006,GO:0086012,GO:0086047,GO:0086062,GO:0086091,GO:1905150,GO:2000649" voltage-gated sodium channel complex|voltage-gated ion channel activity|voltage-gated sodium channel activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|cell adhesion|axon guidance|positive regulation of sodium ion transport|positive regulation of neuron projection development|intercalated disc|sodium channel regulator activity|neuronal action potential propagation|sodium channel inhibitor activity|corticospinal neuron axon guidance|T-tubule|node of Ranvier|sodium ion transmembrane transport|locomotion|perikaryon|ion channel binding|response to pyrethroid|membrane depolarization|cardiac muscle contraction|regulation of ventricular cardiac muscle cell membrane repolarization|regulation of atrial cardiac muscle cell membrane depolarization|cardiac conduction|cardiac muscle cell action potential involved in contraction|voltage-gated sodium channel activity involved in cardiac muscle cell action potential|membrane depolarization during cardiac muscle cell action potential|membrane depolarization during Purkinje myocyte cell action potential|voltage-gated sodium channel activity involved in Purkinje myocyte action potential|regulation of heart rate by cardiac conduction|regulation of voltage-gated sodium channel activity|regulation of sodium ion transmembrane transporter activity hsa04261 Adrenergic signaling in cardiomyocytes SCN2A 49.40518255 35.37407201 63.4362931 1.793299145 0.842616168 0.163665395 1 0.17688084 0.311892343 6326 sodium voltage-gated channel alpha subunit 2 "GO:0001518,GO:0005244,GO:0005248,GO:0005886,GO:0005887,GO:0006814,GO:0007399,GO:0007613,GO:0008627,GO:0014704,GO:0016020,GO:0019228,GO:0030315,GO:0030424,GO:0031226,GO:0033268,GO:0033270,GO:0034706,GO:0034765,GO:0035725,GO:0042552,GO:0051402,GO:0071456,GO:0086010,GO:0098978,GO:0099056" voltage-gated sodium channel complex|voltage-gated ion channel activity|voltage-gated sodium channel activity|plasma membrane|integral component of plasma membrane|sodium ion transport|nervous system development|memory|intrinsic apoptotic signaling pathway in response to osmotic stress|intercalated disc|membrane|neuronal action potential|T-tubule|axon|intrinsic component of plasma membrane|node of Ranvier|paranode region of axon|sodium channel complex|regulation of ion transmembrane transport|sodium ion transmembrane transport|myelination|neuron apoptotic process|cellular response to hypoxia|membrane depolarization during action potential|glutamatergic synapse|integral component of presynaptic membrane hsa04742 Taste transduction SCN3A 10.48842717 10.40413883 10.57271552 1.016202849 0.023188414 1 1 0.049713472 0.049673605 6328 sodium voltage-gated channel alpha subunit 3 "GO:0001518,GO:0005244,GO:0005248,GO:0005737,GO:0006814,GO:0019228,GO:0030424,GO:0034765,GO:0035725,GO:0086010" voltage-gated sodium channel complex|voltage-gated ion channel activity|voltage-gated sodium channel activity|cytoplasm|sodium ion transport|neuronal action potential|axon|regulation of ion transmembrane transport|sodium ion transmembrane transport|membrane depolarization during action potential hsa04742 Taste transduction SCN4B 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.03225545 6330 sodium voltage-gated channel beta subunit 4 "GO:0001518,GO:0005244,GO:0005248,GO:0005515,GO:0006814,GO:0010765,GO:0014704,GO:0017080,GO:0031226,GO:0035725,GO:0044325,GO:0060048,GO:0060307,GO:0086002,GO:0086006,GO:0086012,GO:0086016,GO:0086091,GO:2000649" voltage-gated sodium channel complex|voltage-gated ion channel activity|voltage-gated sodium channel activity|protein binding|sodium ion transport|positive regulation of sodium ion transport|intercalated disc|sodium channel regulator activity|intrinsic component of plasma membrane|sodium ion transmembrane transport|ion channel binding|cardiac muscle contraction|regulation of ventricular cardiac muscle cell membrane repolarization|cardiac muscle cell action potential involved in contraction|voltage-gated sodium channel activity involved in cardiac muscle cell action potential|membrane depolarization during cardiac muscle cell action potential|AV node cell action potential|regulation of heart rate by cardiac conduction|regulation of sodium ion transmembrane transporter activity hsa04261 Adrenergic signaling in cardiomyocytes SCN5A 8.447228369 7.282897178 9.61155956 1.31974396 0.400258063 0.833324456 1 0.045131774 0.05856569 6331 sodium voltage-gated channel alpha subunit 5 "GO:0001518,GO:0002027,GO:0003231,GO:0003360,GO:0005244,GO:0005248,GO:0005515,GO:0005516,GO:0005654,GO:0005730,GO:0005783,GO:0005886,GO:0005901,GO:0006814,GO:0009986,GO:0010765,GO:0014704,GO:0014894,GO:0016021,GO:0016328,GO:0017134,GO:0019228,GO:0019899,GO:0019901,GO:0019904,GO:0021537,GO:0021549,GO:0030018,GO:0030315,GO:0030506,GO:0031625,GO:0035725,GO:0042383,GO:0042475,GO:0044325,GO:0045760,GO:0048471,GO:0050679,GO:0050998,GO:0051899,GO:0060048,GO:0060307,GO:0060371,GO:0060372,GO:0060373,GO:0061337,GO:0071277,GO:0086002,GO:0086004,GO:0086005,GO:0086006,GO:0086010,GO:0086012,GO:0086014,GO:0086015,GO:0086016,GO:0086043,GO:0086045,GO:0086046,GO:0086047,GO:0086048,GO:0086060,GO:0086061,GO:0086062,GO:0086063,GO:0086067,GO:0086091,GO:0097110,GO:0098912,GO:1902305" voltage-gated sodium channel complex|regulation of heart rate|cardiac ventricle development|brainstem development|voltage-gated ion channel activity|voltage-gated sodium channel activity|protein binding|calmodulin binding|nucleoplasm|nucleolus|endoplasmic reticulum|plasma membrane|caveola|sodium ion transport|cell surface|positive regulation of sodium ion transport|intercalated disc|response to denervation involved in regulation of muscle adaptation|integral component of membrane|lateral plasma membrane|fibroblast growth factor binding|neuronal action potential|enzyme binding|protein kinase binding|protein domain specific binding|telencephalon development|cerebellum development|Z disc|T-tubule|ankyrin binding|ubiquitin protein ligase binding|sodium ion transmembrane transport|sarcolemma|odontogenesis of dentin-containing tooth|ion channel binding|positive regulation of action potential|perinuclear region of cytoplasm|positive regulation of epithelial cell proliferation|nitric-oxide synthase binding|membrane depolarization|cardiac muscle contraction|regulation of ventricular cardiac muscle cell membrane repolarization|regulation of atrial cardiac muscle cell membrane depolarization|regulation of atrial cardiac muscle cell membrane repolarization|regulation of ventricular cardiac muscle cell membrane depolarization|cardiac conduction|cellular response to calcium ion|cardiac muscle cell action potential involved in contraction|regulation of cardiac muscle cell contraction|ventricular cardiac muscle cell action potential|voltage-gated sodium channel activity involved in cardiac muscle cell action potential|membrane depolarization during action potential|membrane depolarization during cardiac muscle cell action potential|atrial cardiac muscle cell action potential|SA node cell action potential|AV node cell action potential|bundle of His cell action potential|membrane depolarization during AV node cell action potential|membrane depolarization during SA node cell action potential|membrane depolarization during Purkinje myocyte cell action potential|membrane depolarization during bundle of His cell action potential|voltage-gated sodium channel activity involved in AV node cell action potential|voltage-gated sodium channel activity involved in bundle of His cell action potential|voltage-gated sodium channel activity involved in Purkinje myocyte action potential|voltage-gated sodium channel activity involved in SA node cell action potential|AV node cell to bundle of His cell communication|regulation of heart rate by cardiac conduction|scaffold protein binding|membrane depolarization during atrial cardiac muscle cell action potential|regulation of sodium ion transmembrane transport hsa04261 Adrenergic signaling in cardiomyocytes SCN9A 285.7388785 310.043337 261.43442 0.843218959 -0.246020789 0.446348465 1 1.656466419 1.373390938 6335 sodium voltage-gated channel alpha subunit 9 "GO:0001518,GO:0005244,GO:0005248,GO:0005887,GO:0006814,GO:0006954,GO:0009636,GO:0009791,GO:0019228,GO:0019233,GO:0030424,GO:0031402,GO:0034765,GO:0035725,GO:0048266,GO:0086010" voltage-gated sodium channel complex|voltage-gated ion channel activity|voltage-gated sodium channel activity|integral component of plasma membrane|sodium ion transport|inflammatory response|response to toxic substance|post-embryonic development|neuronal action potential|sensory perception of pain|axon|sodium ion binding|regulation of ion transmembrane transport|sodium ion transmembrane transport|behavioral response to pain|membrane depolarization during action potential hsa04742 Taste transduction SCNN1A 72.6163501 76.99062732 68.24207288 0.886368578 -0.174021356 0.760460019 1 1.061717901 0.925325798 6337 sodium channel epithelial 1 subunit alpha "GO:0001669,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0015280,GO:0016324,GO:0031514,GO:0034220,GO:0034706,GO:0035725,GO:0050699,GO:0050891,GO:0050896,GO:0050909,GO:0055078,GO:0060170,GO:0070062,GO:0097228" acrosomal vesicle|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|ligand-gated sodium channel activity|apical plasma membrane|motile cilium|ion transmembrane transport|sodium channel complex|sodium ion transmembrane transport|WW domain binding|multicellular organismal water homeostasis|response to stimulus|sensory perception of taste|sodium ion homeostasis|ciliary membrane|extracellular exosome|sperm principal piece "hsa04742,hsa04960" Taste transduction|Aldosterone-regulated sodium reabsorption SCNN1D 53.12085865 57.22276355 49.01895376 0.856633807 -0.223249481 0.726827088 1 1.001270072 0.84336898 6339 sodium channel epithelial 1 subunit delta "GO:0005515,GO:0005886,GO:0005887,GO:0006814,GO:0015280,GO:0015629,GO:0016020,GO:0034220,GO:0034706,GO:0035725,GO:0050896,GO:0050909" protein binding|plasma membrane|integral component of plasma membrane|sodium ion transport|ligand-gated sodium channel activity|actin cytoskeleton|membrane|ion transmembrane transport|sodium channel complex|sodium ion transmembrane transport|response to stimulus|sensory perception of taste SCO1 770.8226544 756.3808927 785.264416 1.038186479 0.054065604 0.835351481 1 4.214958554 4.302688005 6341 synthesis of cytochrome C oxidase 1 "GO:0005515,GO:0005739,GO:0006878,GO:0016531,GO:0030016,GO:0031305,GO:0033617" protein binding|mitochondrion|cellular copper ion homeostasis|copper chaperone activity|myofibril|integral component of mitochondrial inner membrane|mitochondrial cytochrome c oxidase assembly SCO2 207.5688288 200.7998793 214.3377782 1.067419855 0.094127753 0.804625462 1 7.902891229 8.294542947 9997 synthesis of cytochrome C oxidase 2 "GO:0001654,GO:0001701,GO:0003012,GO:0005507,GO:0005515,GO:0005739,GO:0005759,GO:0006878,GO:0014823,GO:0015035,GO:0016531,GO:0022904,GO:0030016,GO:0031305,GO:0033617,GO:0055114" eye development|in utero embryonic development|muscle system process|copper ion binding|protein binding|mitochondrion|mitochondrial matrix|cellular copper ion homeostasis|response to activity|protein disulfide oxidoreductase activity|copper chaperone activity|respiratory electron transport chain|myofibril|integral component of mitochondrial inner membrane|mitochondrial cytochrome c oxidase assembly|oxidation-reduction process hsa05230 Central carbon metabolism in cancer SCOC 2037.705578 1553.337927 2522.073229 1.623647492 0.699238445 0.003218815 0.367925679 15.07250732 24.06292558 60592 short coiled-coil protein "GO:0000139,GO:0005515,GO:0005654,GO:0005768,GO:0005794,GO:0005802,GO:0005829,GO:0016239,GO:0061635" Golgi membrane|protein binding|nucleoplasm|endosome|Golgi apparatus|trans-Golgi network|cytosol|positive regulation of macroautophagy|regulation of protein complex stability SCP2 1627.65429 1449.296539 1806.012041 1.246130101 0.317454699 0.182004652 1 18.4773752 22.63991765 6342 sterol carrier protein 2 "GO:0000062,GO:0003988,GO:0005102,GO:0005515,GO:0005654,GO:0005739,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0006635,GO:0006694,GO:0006699,GO:0008206,GO:0015485,GO:0015914,GO:0016020,GO:0032385,GO:0032934,GO:0032991,GO:0033540,GO:0033814,GO:0036042,GO:0036109,GO:0043231,GO:0050632,GO:0050633,GO:0070538,GO:1901373" fatty-acyl-CoA binding|acetyl-CoA C-acyltransferase activity|signaling receptor binding|protein binding|nucleoplasm|mitochondrion|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid beta-oxidation|steroid biosynthetic process|bile acid biosynthetic process|bile acid metabolic process|cholesterol binding|phospholipid transport|membrane|positive regulation of intracellular cholesterol transport|sterol binding|protein-containing complex|fatty acid beta-oxidation using acyl-CoA oxidase|propanoyl-CoA C-acyltransferase activity|long-chain fatty acyl-CoA binding|alpha-linolenic acid metabolic process|intracellular membrane-bounded organelle|propionyl-CoA C2-trimethyltridecanoyltransferase activity|acetyl-CoA C-myristoyltransferase activity|oleic acid binding|lipid hydroperoxide transport "hsa00120,hsa01040,hsa03320,hsa04146" Primary bile acid biosynthesis|Biosynthesis of unsaturated fatty acids|PPAR signaling pathway|Peroxisome SCPEP1 1362.752028 1408.720397 1316.78366 0.934737413 -0.097366956 0.686796838 1 39.09558943 35.93259393 59342 serine carboxypeptidase 1 "GO:0004185,GO:0005829,GO:0006508,GO:0042573,GO:0045776,GO:0070062,GO:0097746" serine-type carboxypeptidase activity|cytosol|proteolysis|retinoic acid metabolic process|negative regulation of blood pressure|extracellular exosome|blood vessel diameter maintenance SCRIB 1744.819124 1787.43105 1702.207198 0.952320481 -0.070480934 0.76828182 1 17.01300339 15.93071586 23513 scribble planar cell polarity protein "GO:0001768,GO:0001772,GO:0001843,GO:0001921,GO:0005515,GO:0005654,GO:0005886,GO:0005911,GO:0005912,GO:0008283,GO:0008328,GO:0009790,GO:0014069,GO:0016323,GO:0016477,GO:0030027,GO:0030054,GO:0030683,GO:0030859,GO:0031252,GO:0032729,GO:0034750,GO:0035089,GO:0039563,GO:0039564,GO:0042734,GO:0043065,GO:0043113,GO:0045197,GO:0045211,GO:0045296,GO:0045930,GO:0046007,GO:0050918,GO:0060561,GO:0060603,GO:0070062,GO:0071896,GO:0090630,GO:0097120,GO:0098609,GO:0098887,GO:0098968" "establishment of T cell polarity|immunological synapse|neural tube closure|positive regulation of receptor recycling|protein binding|nucleoplasm|plasma membrane|cell-cell junction|adherens junction|cell population proliferation|ionotropic glutamate receptor complex|embryo development|postsynaptic density|basolateral plasma membrane|cell migration|lamellipodium|cell junction|mitigation of host immune response by virus|polarized epithelial cell differentiation|cell leading edge|positive regulation of interferon-gamma production|Scrib-APC-beta-catenin complex|establishment of apical/basal cell polarity|suppression by virus of host STAT1 activity|suppression by virus of host STAT2 activity|presynaptic membrane|positive regulation of apoptotic process|receptor clustering|establishment or maintenance of epithelial cell apical/basal polarity|postsynaptic membrane|cadherin binding|negative regulation of mitotic cell cycle|negative regulation of activated T cell proliferation|positive chemotaxis|apoptotic process involved in morphogenesis|mammary gland duct morphogenesis|extracellular exosome|protein localization to adherens junction|activation of GTPase activity|receptor localization to synapse|cell-cell adhesion|neurotransmitter receptor transport, endosome to postsynaptic membrane|neurotransmitter receptor transport postsynaptic membrane to endosome" "hsa04390,hsa04530,hsa05165,hsa05203" Hippo signaling pathway|Tight junction|Human papillomavirus infection|Viral carcinogenesis SCRN1 7015.485849 6737.720304 7293.251394 1.082450898 0.114301583 0.64028965 1 58.98617933 62.78120549 9805 secernin 1 "GO:0003674,GO:0005515,GO:0005634,GO:0005737,GO:0006508,GO:0006887,GO:0016805,GO:0031965,GO:0070004" molecular_function|protein binding|nucleus|cytoplasm|proteolysis|exocytosis|dipeptidase activity|nuclear membrane|cysteine-type exopeptidase activity SCRN2 697.0470035 674.188196 719.905811 1.067811355 0.094656796 0.716053204 1 16.42180964 17.24196371 90507 secernin 2 "GO:0003674,GO:0005515,GO:0006508,GO:0008150,GO:0016805,GO:0070004,GO:0070062" molecular_function|protein binding|proteolysis|biological_process|dipeptidase activity|cysteine-type exopeptidase activity|extracellular exosome SCRN3 485.8266653 491.0753526 480.577978 0.978623699 -0.031173875 0.917557758 1 5.100776374 4.908210623 79634 secernin 3 "GO:0006508,GO:0016805,GO:0070004" proteolysis|dipeptidase activity|cysteine-type exopeptidase activity SCUBE2 14.97214483 14.56579436 15.3784953 1.055795168 0.078329968 1 1 0.105978142 0.110018863 57758 "signal peptide, CUB domain and EGF like domain containing 2" "GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0007165,GO:0007275,GO:0008289,GO:0009986" calcium ion binding|protein binding|extracellular region|extracellular space|signal transduction|multicellular organism development|lipid binding|cell surface SCUBE3 9.527271215 10.40413883 8.650403604 0.831438695 -0.266318203 0.910300494 1 0.069198625 0.056571654 222663 "signal peptide, CUB domain and EGF like domain containing 3" "GO:0005509,GO:0005515,GO:0005615,GO:0005886,GO:0007165,GO:0009986,GO:0022617,GO:0042802" calcium ion binding|protein binding|extracellular space|plasma membrane|signal transduction|cell surface|extracellular matrix disassembly|identical protein binding SCX 29.06239162 31.21241648 26.91236677 0.86223272 -0.213850783 0.81124801 1 0.797009235 0.675707955 642658 scleraxis bHLH transcription factor "GO:0000785,GO:0000977,GO:0000981,GO:0001228,GO:0001707,GO:0001894,GO:0001958,GO:0002062,GO:0003179,GO:0003188,GO:0003677,GO:0005515,GO:0005634,GO:0005667,GO:0006351,GO:0006357,GO:0008284,GO:0010628,GO:0030154,GO:0030199,GO:0030509,GO:0032502,GO:0032967,GO:0035914,GO:0035989,GO:0035990,GO:0035992,GO:0035993,GO:0043066,GO:0043425,GO:0043565,GO:0045892,GO:0045893,GO:0045944,GO:0046983,GO:0048706,GO:0060008,GO:0060325,GO:0061035,GO:0061036,GO:0061056,GO:0070888,GO:0071260,GO:0071560,GO:2000543" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|mesoderm formation|tissue homeostasis|endochondral ossification|chondrocyte differentiation|heart valve morphogenesis|heart valve formation|DNA binding|protein binding|nucleus|transcription regulator complex|transcription, DNA-templated|regulation of transcription by RNA polymerase II|positive regulation of cell population proliferation|positive regulation of gene expression|cell differentiation|collagen fibril organization|BMP signaling pathway|developmental process|positive regulation of collagen biosynthetic process|skeletal muscle cell differentiation|tendon development|tendon cell differentiation|tendon formation|deltoid tuberosity development|negative regulation of apoptotic process|bHLH transcription factor binding|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|embryonic skeletal system development|Sertoli cell differentiation|face morphogenesis|regulation of cartilage development|positive regulation of cartilage development|sclerotome development|E-box binding|cellular response to mechanical stimulus|cellular response to transforming growth factor beta stimulus|positive regulation of gastrulation" SCYL1 2075.247339 2009.039207 2141.45547 1.065910243 0.092085958 0.698317651 1 40.5057537 42.45301429 57410 SCY1 like pseudokinase 1 "GO:0003677,GO:0004713,GO:0005524,GO:0005634,GO:0005737,GO:0005793,GO:0005794,GO:0005801,GO:0005815,GO:0005829,GO:0006890,GO:0006954,GO:0016020,GO:0018108,GO:0021522,GO:0030126,GO:0034613,GO:0045296,GO:0048666" "DNA binding|protein tyrosine kinase activity|ATP binding|nucleus|cytoplasm|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|microtubule organizing center|cytosol|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|inflammatory response|membrane|peptidyl-tyrosine phosphorylation|spinal cord motor neuron differentiation|COPI vesicle coat|cellular protein localization|cadherin binding|neuron development" SCYL2 1783.632084 1771.824842 1795.439326 1.013327775 0.01910091 0.938307266 1 16.50532996 16.44543389 55681 SCY1 like pseudokinase 2 "GO:0002092,GO:0004672,GO:0005102,GO:0005515,GO:0005524,GO:0005794,GO:0006468,GO:0007420,GO:0008333,GO:0010008,GO:0021860,GO:0030136,GO:0090090,GO:2000286,GO:2000370" positive regulation of receptor internalization|protein kinase activity|signaling receptor binding|protein binding|ATP binding|Golgi apparatus|protein phosphorylation|brain development|endosome to lysosome transport|endosome membrane|pyramidal neuron development|clathrin-coated vesicle|negative regulation of canonical Wnt signaling pathway|receptor internalization involved in canonical Wnt signaling pathway|positive regulation of clathrin-dependent endocytosis SCYL3 174.8599581 174.7895323 174.930384 1.000805836 0.001162108 1 1 1.380932063 1.358918219 57147 SCY1 like pseudokinase 3 "GO:0000139,GO:0005515,GO:0005524,GO:0005737,GO:0005794,GO:0006468,GO:0006954,GO:0016301,GO:0016477,GO:0021522,GO:0030027,GO:0034613,GO:0042802,GO:0048666" Golgi membrane|protein binding|ATP binding|cytoplasm|Golgi apparatus|protein phosphorylation|inflammatory response|kinase activity|cell migration|spinal cord motor neuron differentiation|lamellipodium|cellular protein localization|identical protein binding|neuron development SDAD1 803.2585383 863.5435226 742.973554 0.860377659 -0.216958032 0.389325736 1 14.68633865 12.4243547 55153 SDA1 domain containing 1 "GO:0000055,GO:0003674,GO:0005654,GO:0005730,GO:0030036,GO:0042273" ribosomal large subunit export from nucleus|molecular_function|nucleoplasm|nucleolus|actin cytoskeleton organization|ribosomal large subunit biogenesis SDC1 2733.493901 2270.183092 3196.80471 1.408170434 0.493821957 0.037021035 0.976206556 32.72703922 45.31407479 6382 syndecan 1 "GO:0001523,GO:0001657,GO:0005515,GO:0005796,GO:0005886,GO:0005887,GO:0006024,GO:0006027,GO:0006954,GO:0008022,GO:0009636,GO:0009897,GO:0009986,GO:0016477,GO:0019221,GO:0032991,GO:0042060,GO:0042476,GO:0042542,GO:0042802,GO:0043202,GO:0048627,GO:0050900,GO:0051384,GO:0051591,GO:0051592,GO:0055002,GO:0060009,GO:0060070,GO:0070062,GO:1903543,GO:1903553" retinoid metabolic process|ureteric bud development|protein binding|Golgi lumen|plasma membrane|integral component of plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|inflammatory response|protein C-terminus binding|response to toxic substance|external side of plasma membrane|cell surface|cell migration|cytokine-mediated signaling pathway|protein-containing complex|wound healing|odontogenesis|response to hydrogen peroxide|identical protein binding|lysosomal lumen|myoblast development|leukocyte migration|response to glucocorticoid|response to cAMP|response to calcium ion|striated muscle cell development|Sertoli cell development|canonical Wnt signaling pathway|extracellular exosome|positive regulation of exosomal secretion|positive regulation of extracellular exosome assembly "hsa04512,hsa04514,hsa05144,hsa05205,hsa05418" ECM-receptor interaction|Cell adhesion molecules|Malaria|Proteoglycans in cancer|Fluid shear stress and atherosclerosis SDC2 37.23221725 31.21241648 43.25201802 1.385731158 0.470647391 0.497523412 1 0.42591391 0.580325941 6383 syndecan 2 "GO:0001523,GO:0005515,GO:0005788,GO:0005796,GO:0005886,GO:0006024,GO:0006027,GO:0008150,GO:0009986,GO:0016021,GO:0016477,GO:0030165,GO:0042802,GO:0043202,GO:0043687,GO:0044267,GO:0048013,GO:0048813,GO:0048814,GO:0050900,GO:0062023" retinoid metabolic process|protein binding|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|biological_process|cell surface|integral component of membrane|cell migration|PDZ domain binding|identical protein binding|lysosomal lumen|post-translational protein modification|cellular protein metabolic process|ephrin receptor signaling pathway|dendrite morphogenesis|regulation of dendrite morphogenesis|leukocyte migration|collagen-containing extracellular matrix "hsa04514,hsa05144,hsa05205,hsa05418" Cell adhesion molecules|Malaria|Proteoglycans in cancer|Fluid shear stress and atherosclerosis SDC3 1301.114744 1317.163975 1285.065513 0.975630625 -0.035593049 0.885529071 1 12.15539003 11.66072361 9672 syndecan 3 "GO:0001523,GO:0005515,GO:0005796,GO:0005886,GO:0006024,GO:0006027,GO:0009986,GO:0016020,GO:0016021,GO:0016477,GO:0042802,GO:0043202,GO:0044393,GO:0050900,GO:0062023" retinoid metabolic process|protein binding|Golgi lumen|plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|cell surface|membrane|integral component of membrane|cell migration|identical protein binding|lysosomal lumen|microspike|leukocyte migration|collagen-containing extracellular matrix hsa04514 Cell adhesion molecules SDC4 7842.975348 8590.697429 7095.253267 0.825922846 -0.275921078 0.262770945 1 175.8610406 142.8171283 6385 syndecan 4 "GO:0001523,GO:0001657,GO:0001843,GO:0001968,GO:0005080,GO:0005515,GO:0005796,GO:0005886,GO:0005887,GO:0005925,GO:0006024,GO:0006027,GO:0009986,GO:0010762,GO:0016477,GO:0042060,GO:0042130,GO:0042802,GO:0043034,GO:0043202,GO:0045121,GO:0045860,GO:0050900,GO:0051496,GO:0051894,GO:0060122,GO:0070053,GO:0070062,GO:1903543,GO:1903553" retinoid metabolic process|ureteric bud development|neural tube closure|fibronectin binding|protein kinase C binding|protein binding|Golgi lumen|plasma membrane|integral component of plasma membrane|focal adhesion|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|cell surface|regulation of fibroblast migration|cell migration|wound healing|negative regulation of T cell proliferation|identical protein binding|costamere|lysosomal lumen|membrane raft|positive regulation of protein kinase activity|leukocyte migration|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|inner ear receptor cell stereocilium organization|thrombospondin receptor activity|extracellular exosome|positive regulation of exosomal secretion|positive regulation of extracellular exosome assembly "hsa04512,hsa04514,hsa05205,hsa05418" ECM-receptor interaction|Cell adhesion molecules|Proteoglycans in cancer|Fluid shear stress and atherosclerosis SDCBP 10347.36496 10435.35124 10259.37867 0.983136881 -0.024535799 0.922825765 1 127.207747 122.969874 6386 syndecan binding protein "GO:0002091,GO:0005109,GO:0005137,GO:0005515,GO:0005546,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005789,GO:0005829,GO:0005856,GO:0005886,GO:0005895,GO:0005912,GO:0005925,GO:0006612,GO:0006930,GO:0007268,GO:0007346,GO:0008093,GO:0008284,GO:0010718,GO:0010862,GO:0016020,GO:0030036,GO:0030307,GO:0030335,GO:0030511,GO:0031965,GO:0032435,GO:0035556,GO:0035578,GO:0042327,GO:0042470,GO:0042802,GO:0043312,GO:0045121,GO:0045202,GO:0045545,GO:0046330,GO:0046982,GO:0047485,GO:0048013,GO:0070062,GO:0072562,GO:1903543,GO:1903553,GO:1903561" "negative regulation of receptor internalization|frizzled binding|interleukin-5 receptor binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular region|extracellular space|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum membrane|cytosol|cytoskeleton|plasma membrane|interleukin-5 receptor complex|adherens junction|focal adhesion|protein targeting to membrane|substrate-dependent cell migration, cell extension|chemical synaptic transmission|regulation of mitotic cell cycle|cytoskeletal anchor activity|positive regulation of cell population proliferation|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|membrane|actin cytoskeleton organization|positive regulation of cell growth|positive regulation of cell migration|positive regulation of transforming growth factor beta receptor signaling pathway|nuclear membrane|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|intracellular signal transduction|azurophil granule lumen|positive regulation of phosphorylation|melanosome|identical protein binding|neutrophil degranulation|membrane raft|synapse|syndecan binding|positive regulation of JNK cascade|protein heterodimerization activity|protein N-terminus binding|ephrin receptor signaling pathway|extracellular exosome|blood microparticle|positive regulation of exosomal secretion|positive regulation of extracellular exosome assembly|extracellular vesicle" SDCBP2 74.45940408 74.90979955 74.00900861 0.987974992 -0.017453571 1 1 2.351646073 2.284489101 27111 syndecan binding protein 2 "GO:0005515,GO:0005546,GO:0005654,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0007399,GO:0008022,GO:0008283,GO:0016607,GO:0035556,GO:0042802,GO:0042803,GO:0046907,GO:0046982,GO:0070062" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|nucleoplasm|nucleolus|cytoplasm|Golgi apparatus|cytosol|plasma membrane|nervous system development|protein C-terminus binding|cell population proliferation|nuclear speck|intracellular signal transduction|identical protein binding|protein homodimerization activity|intracellular transport|protein heterodimerization activity|extracellular exosome" SDCCAG8 722.6956595 729.3301317 716.0611872 0.981806669 -0.026489129 0.922929891 1 3.491165905 3.370292888 10806 SHH signaling and ciliogenesis regulator SDCCAG8 "GO:0000086,GO:0001764,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0005911,GO:0007098,GO:0010389,GO:0030010,GO:0031023,GO:0034451,GO:0035148,GO:0036064,GO:0097711,GO:0097733,GO:1902017" G2/M transition of mitotic cell cycle|neuron migration|protein binding|centrosome|centriole|cytosol|cell-cell junction|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|establishment of cell polarity|microtubule organizing center organization|centriolar satellite|tube formation|ciliary basal body|ciliary basal body-plasma membrane docking|photoreceptor cell cilium|regulation of cilium assembly SDE2 711.2360155 743.8959261 678.5761049 0.912192259 -0.132590168 0.606914232 1 9.957451305 8.93111645 163859 SDE2 telomere maintenance homolog "GO:0003684,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0005886,GO:0006260,GO:0007049,GO:0016485,GO:0016567,GO:0016607,GO:0034644,GO:0051301,GO:0071156" damaged DNA binding|protein binding|nucleus|nucleoplasm|Golgi apparatus|cytosol|plasma membrane|DNA replication|cell cycle|protein processing|protein ubiquitination|nuclear speck|cellular response to UV|cell division|regulation of cell cycle arrest SDF2 547.816194 503.5603192 592.0720689 1.175771891 0.233608194 0.384686156 1 18.04841419 20.86571644 6388 stromal cell derived factor 2 "GO:0005783,GO:0016020,GO:0051085,GO:0051787,GO:0101031" endoplasmic reticulum|membrane|chaperone cofactor-dependent protein refolding|misfolded protein binding|chaperone complex SDF2L1 385.0247912 393.2764476 376.7731347 0.958036356 -0.06184769 0.840617018 1 25.44053479 23.96510881 23753 stromal cell derived factor 2 like 1 "GO:0004169,GO:0005515,GO:0005783,GO:0005788,GO:0005789,GO:0034663,GO:0035269,GO:0042981,GO:0051085,GO:0051087,GO:0051117,GO:0051787,GO:0071712,GO:0101031" dolichyl-phosphate-mannose-protein mannosyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endoplasmic reticulum chaperone complex|protein O-linked mannosylation|regulation of apoptotic process|chaperone cofactor-dependent protein refolding|chaperone binding|ATPase binding|misfolded protein binding|ER-associated misfolded protein catabolic process|chaperone complex SDF4 3012.229858 2964.139152 3060.320564 1.032448346 0.046069604 0.846939117 1 40.84447681 41.46415781 51150 stromal cell derived factor 4 "GO:0005509,GO:0005515,GO:0005737,GO:0005770,GO:0005783,GO:0005794,GO:0005796,GO:0005886,GO:0009650,GO:0016020,GO:0017156,GO:0021549,GO:0032059,GO:0042802,GO:0045444,GO:0045471,GO:0070062,GO:0070625" calcium ion binding|protein binding|cytoplasm|late endosome|endoplasmic reticulum|Golgi apparatus|Golgi lumen|plasma membrane|UV protection|membrane|calcium-ion regulated exocytosis|cerebellum development|bleb|identical protein binding|fat cell differentiation|response to ethanol|extracellular exosome|zymogen granule exocytosis SDHA 3109.188337 2860.097763 3358.27891 1.174183258 0.231657591 0.328155596 1 36.23887963 41.83905096 6389 succinate dehydrogenase complex flavoprotein subunit A "GO:0000104,GO:0005515,GO:0005730,GO:0005739,GO:0005743,GO:0005749,GO:0006099,GO:0006105,GO:0006121,GO:0007399,GO:0008177,GO:0009055,GO:0022904,GO:0050660,GO:0055114" "succinate dehydrogenase activity|protein binding|nucleolus|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)|tricarboxylic acid cycle|succinate metabolic process|mitochondrial electron transport, succinate to ubiquinone|nervous system development|succinate dehydrogenase (ubiquinone) activity|electron transfer activity|respiratory electron transport chain|flavin adenine dinucleotide binding|oxidation-reduction process" "hsa00020,hsa00190,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Citrate cycle (TCA cycle)|Oxidative phosphorylation|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases SDHAF1 126.9116008 101.9605605 151.862641 1.489425326 0.574755794 0.182923025 1 4.836842416 7.083564474 644096 succinate dehydrogenase complex assembly factor 1 "GO:0005515,GO:0005739,GO:0005759,GO:0034553" protein binding|mitochondrion|mitochondrial matrix|mitochondrial respiratory chain complex II assembly SDHAF2 670.2786757 614.8846046 725.6727468 1.180177128 0.239003404 0.355256459 1 27.66885433 32.10772608 54949 succinate dehydrogenase complex assembly factor 2 "GO:0005515,GO:0005730,GO:0005739,GO:0005759,GO:0005829,GO:0006099,GO:0006121,GO:0006470,GO:0010719,GO:0018293,GO:0034553,GO:0090090" "protein binding|nucleolus|mitochondrion|mitochondrial matrix|cytosol|tricarboxylic acid cycle|mitochondrial electron transport, succinate to ubiquinone|protein dephosphorylation|negative regulation of epithelial to mesenchymal transition|protein-FAD linkage|mitochondrial respiratory chain complex II assembly|negative regulation of canonical Wnt signaling pathway" SDHAF3 213.5043412 179.9916017 247.0170807 1.372381146 0.456681212 0.198532798 1 10.09014808 13.61580935 57001 succinate dehydrogenase complex assembly factor 3 "GO:0005758,GO:0005759,GO:0006105,GO:0006111,GO:0034553" mitochondrial intermembrane space|mitochondrial matrix|succinate metabolic process|regulation of gluconeogenesis|mitochondrial respiratory chain complex II assembly SDHAF4 184.7243827 143.5771158 225.8716497 1.573173053 0.65367738 0.081263149 1 6.477131688 10.01913906 135154 succinate dehydrogenase complex assembly factor 4 "GO:0003674,GO:0005515,GO:0005575,GO:0005739,GO:0005749,GO:0005759,GO:0008177,GO:0034553,GO:0045087,GO:0045333" "molecular_function|protein binding|cellular_component|mitochondrion|mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)|mitochondrial matrix|succinate dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex II assembly|innate immune response|cellular respiration" SDHB 1407.258311 1277.628248 1536.888374 1.202922976 0.266544268 0.265854199 1 67.17701617 79.45655074 6390 succinate dehydrogenase complex iron sulfur subunit B "GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005749,GO:0005886,GO:0006099,GO:0006105,GO:0008177,GO:0009055,GO:0009060,GO:0022904,GO:0031966,GO:0046872,GO:0048039,GO:0051537,GO:0051538,GO:0051539" "protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)|plasma membrane|tricarboxylic acid cycle|succinate metabolic process|succinate dehydrogenase (ubiquinone) activity|electron transfer activity|aerobic respiration|respiratory electron transport chain|mitochondrial membrane|metal ion binding|ubiquinone binding|2 iron, 2 sulfur cluster binding|3 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding" "hsa00020,hsa00190,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Citrate cycle (TCA cycle)|Oxidative phosphorylation|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases SDHC 2037.673552 1931.008166 2144.338938 1.110476369 0.151178693 0.523506792 1 78.78773455 86.02785867 6391 succinate dehydrogenase complex subunit C "GO:0000104,GO:0005515,GO:0005739,GO:0005743,GO:0005749,GO:0006099,GO:0006121,GO:0009055,GO:0009060,GO:0016021,GO:0020037,GO:0045273,GO:0046872,GO:0055114" "succinate dehydrogenase activity|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)|tricarboxylic acid cycle|mitochondrial electron transport, succinate to ubiquinone|electron transfer activity|aerobic respiration|integral component of membrane|heme binding|respiratory chain complex II|metal ion binding|oxidation-reduction process" "hsa00020,hsa00190,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Citrate cycle (TCA cycle)|Oxidative phosphorylation|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases SDHD 1547.585852 1479.468541 1615.703162 1.092083486 0.12708315 0.595159182 1 53.74847984 57.7155986 6392 succinate dehydrogenase complex subunit D "GO:0000104,GO:0005515,GO:0005739,GO:0005740,GO:0005743,GO:0005749,GO:0006099,GO:0006121,GO:0009055,GO:0016021,GO:0020037,GO:0046872,GO:0048039" "succinate dehydrogenase activity|protein binding|mitochondrion|mitochondrial envelope|mitochondrial inner membrane|mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)|tricarboxylic acid cycle|mitochondrial electron transport, succinate to ubiquinone|electron transfer activity|integral component of membrane|heme binding|metal ion binding|ubiquinone binding" "hsa00020,hsa00190,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Citrate cycle (TCA cycle)|Oxidative phosphorylation|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases SDK1 262.96866 267.3863678 258.5509522 0.966956372 -0.048477297 0.894573439 1 1.374354138 1.306702472 221935 sidekick cell adhesion molecule 1 "GO:0005886,GO:0007156,GO:0007416,GO:0010842,GO:0016021,GO:0042802,GO:0045202,GO:0045216,GO:0048148,GO:0060998" plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|synapse assembly|retina layer formation|integral component of membrane|identical protein binding|synapse|cell-cell junction organization|behavioral response to cocaine|regulation of dendritic spine development SDK2 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.014415831 0.008729861 54549 sidekick cell adhesion molecule 2 "GO:0005515,GO:0005886,GO:0007156,GO:0007416,GO:0010842,GO:0016021,GO:0045202,GO:0045216,GO:0060219" protein binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|synapse assembly|retina layer formation|integral component of membrane|synapse|cell-cell junction organization|camera-type eye photoreceptor cell differentiation SDR16C5 27.78420396 22.88910542 32.6793025 1.427723011 0.513716113 0.51218899 1 0.398158242 0.558947282 195814 short chain dehydrogenase/reductase family 16C member 5 "GO:0000122,GO:0000785,GO:0003714,GO:0004745,GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0005811,GO:0005886,GO:0008134,GO:0016021,GO:0016616,GO:0017053,GO:0031065,GO:0033613,GO:0035067,GO:0042572,GO:0042574,GO:0043616,GO:0055114" "negative regulation of transcription by RNA polymerase II|chromatin|transcription corepressor activity|retinol dehydrogenase activity|protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|plasma membrane|transcription factor binding|integral component of membrane|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|transcription repressor complex|positive regulation of histone deacetylation|activating transcription factor binding|negative regulation of histone acetylation|retinol metabolic process|retinal metabolic process|keratinocyte proliferation|oxidation-reduction process" hsa00830 Retinol metabolism SDR39U1 451.1659146 439.0546585 463.2771708 1.055169697 0.077475038 0.788906307 1 16.2719029 16.88230853 56948 short chain dehydrogenase/reductase family 39U member 1 "GO:0005634,GO:0016491,GO:0055114" nucleus|oxidoreductase activity|oxidation-reduction process SDR42E1 34.46763627 34.33365813 34.60161442 1.007804478 0.011215772 1 1 0.15414522 0.152748701 93517 "short chain dehydrogenase/reductase family 42E, member 1" "GO:0003854,GO:0006694,GO:0016021,GO:0016616,GO:0055114" "3-beta-hydroxy-delta5-steroid dehydrogenase activity|steroid biosynthetic process|integral component of membrane|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|oxidation-reduction process" SDSL 63.69357417 57.22276355 70.16438479 1.226162115 0.294149735 0.60826206 1 1.435765736 1.731022277 113675 serine dehydratase like "GO:0003674,GO:0003941,GO:0004794,GO:0005829,GO:0006567,GO:0008150,GO:0009097,GO:0019518,GO:0030170,GO:0042802" molecular_function|L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|cytosol|threonine catabolic process|biological_process|isoleucine biosynthetic process|L-threonine catabolic process to glycine|pyridoxal phosphate binding|identical protein binding "hsa00260,hsa00270,hsa00290" "Glycine, serine and threonine metabolism|Cysteine and methionine metabolism|Valine, leucine and isoleucine biosynthesis" SEC11A 2329.798338 2295.153025 2364.443652 1.030189981 0.042910415 0.857597685 1 97.75586483 99.02191541 23478 "SEC11 homolog A, signal peptidase complex subunit" "GO:0004252,GO:0005515,GO:0005787,GO:0005789,GO:0006465,GO:0008233,GO:0016021" serine-type endopeptidase activity|protein binding|signal peptidase complex|endoplasmic reticulum membrane|signal peptide processing|peptidase activity|integral component of membrane hsa03060 Protein export SEC11C 294.7509732 306.9220954 282.5798511 0.920689176 -0.119213909 0.714085913 1 17.00920886 15.39814234 90701 "SEC11 homolog C, signal peptidase complex subunit" "GO:0004252,GO:0005515,GO:0005787,GO:0005789,GO:0006465,GO:0008233,GO:0016021" serine-type endopeptidase activity|protein binding|signal peptidase complex|endoplasmic reticulum membrane|signal peptide processing|peptidase activity|integral component of membrane hsa03060 Protein export SEC13 2302.317918 2015.281691 2589.354145 1.284859659 0.361610787 0.126161942 1 47.80083551 60.38962877 6396 "SEC13 homolog, nuclear pore and COPII coat complex component" "GO:0000139,GO:0000776,GO:0002474,GO:0005198,GO:0005515,GO:0005635,GO:0005654,GO:0005765,GO:0005789,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006886,GO:0012507,GO:0016032,GO:0019083,GO:0019886,GO:0030127,GO:0031080,GO:0032008,GO:0032527,GO:0042802,GO:0043231,GO:0043657,GO:0048208,GO:0060964,GO:0061700,GO:0070062,GO:0075733,GO:0090110,GO:0090114,GO:1900034,GO:1904263" Golgi membrane|kinetochore|antigen processing and presentation of peptide antigen via MHC class I|structural molecule activity|protein binding|nuclear envelope|nucleoplasm|lysosomal membrane|endoplasmic reticulum membrane|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|intracellular protein transport|ER to Golgi transport vesicle membrane|viral process|viral transcription|antigen processing and presentation of exogenous peptide antigen via MHC class II|COPII vesicle coat|nuclear pore outer ring|positive regulation of TOR signaling|protein exit from endoplasmic reticulum|identical protein binding|intracellular membrane-bounded organelle|host cell|COPII vesicle coating|regulation of gene silencing by miRNA|GATOR2 complex|extracellular exosome|intracellular transport of virus|COPII-coated vesicle cargo loading|COPII-coated vesicle budding|regulation of cellular response to heat|positive regulation of TORC1 signaling "hsa03013,hsa04141,hsa04150,hsa05014" RNA transport|Protein processing in endoplasmic reticulum|mTOR signaling pathway|Amyotrophic lateral sclerosis SEC14L1 5924.885725 5963.652375 5886.119075 0.986999024 -0.018879437 0.938524243 1 52.12400369 50.58545594 6397 SEC14 like lipid binding 1 "GO:0005515,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0015871,GO:0039536,GO:0039552,GO:0045087" protein binding|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|choline transport|negative regulation of RIG-I signaling pathway|RIG-I binding|innate immune response SEC14L2 892.2843511 866.6647642 917.903938 1.059122253 0.082869128 0.742267735 1 9.678239298 10.07891141 23541 SEC14 like lipid binding 2 "GO:0005543,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008431,GO:0045540,GO:0045893,GO:0070062" "phospholipid binding|nucleus|nucleoplasm|cytoplasm|cytosol|vitamin E binding|regulation of cholesterol biosynthetic process|positive regulation of transcription, DNA-templated|extracellular exosome" SEC16A 3689.700269 3919.239096 3460.161442 0.882865617 -0.179734237 0.44961926 1 20.58281709 17.86778001 9919 "SEC16 homolog A, endoplasmic reticulum export factor" "GO:0000139,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006888,GO:0006914,GO:0007029,GO:0007030,GO:0012507,GO:0021762,GO:0031090,GO:0032527,GO:0034976,GO:0043000,GO:0048208,GO:0048471,GO:0050821,GO:0070863,GO:0070971,GO:0070973,GO:0072659" Golgi membrane|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|autophagy|endoplasmic reticulum organization|Golgi organization|ER to Golgi transport vesicle membrane|substantia nigra development|organelle membrane|protein exit from endoplasmic reticulum|response to endoplasmic reticulum stress|Golgi to plasma membrane CFTR protein transport|COPII vesicle coating|perinuclear region of cytoplasm|protein stabilization|positive regulation of protein exit from endoplasmic reticulum|endoplasmic reticulum exit site|protein localization to endoplasmic reticulum exit site|protein localization to plasma membrane SEC22A 421.1027381 406.8018281 435.4036481 1.070308976 0.098027333 0.737532042 1 6.204705886 6.529825058 26984 "SEC22 homolog A, vesicle trafficking protein" "GO:0005215,GO:0005515,GO:0005789,GO:0006888,GO:0015031,GO:0016021" transporter activity|protein binding|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|protein transport|integral component of membrane SEC22B 8973.151328 8549.080874 9397.221782 1.099208432 0.136464976 0.583672446 1 50.49792293 54.57889578 9554 "SEC22 homolog B, vesicle trafficking protein" "GO:0000139,GO:0002479,GO:0005484,GO:0005515,GO:0005789,GO:0005793,GO:0006888,GO:0006890,GO:0008021,GO:0012507,GO:0015031,GO:0016021,GO:0019905,GO:0030133,GO:0030137,GO:0030670,GO:0031201,GO:0033116,GO:0042470,GO:0045732,GO:0048208,GO:0048280,GO:1902902,GO:1990668" "Golgi membrane|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|SNAP receptor activity|protein binding|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|synaptic vesicle|ER to Golgi transport vesicle membrane|protein transport|integral component of membrane|syntaxin binding|transport vesicle|COPI-coated vesicle|phagocytic vesicle membrane|SNARE complex|endoplasmic reticulum-Golgi intermediate compartment membrane|melanosome|positive regulation of protein catabolic process|COPII vesicle coating|vesicle fusion with Golgi apparatus|negative regulation of autophagosome assembly|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane" "hsa04130,hsa04145,hsa05134" SNARE interactions in vesicular transport|Phagosome|Legionellosis SEC22C 1580.170191 1615.76276 1544.577621 0.955943323 -0.065003011 0.786968049 1 12.70708648 11.94398662 9117 "SEC22 homolog C, vesicle trafficking protein" "GO:0005515,GO:0005783,GO:0005789,GO:0006888,GO:0015031,GO:0016021" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|protein transport|integral component of membrane SEC23A 4806.736598 4781.742205 4831.730991 1.010454095 0.015003781 0.951001047 1 62.6701358 62.26563228 10484 "SEC23 homolog A, COPII coat complex component" "GO:0000139,GO:0002474,GO:0005096,GO:0005515,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0008270,GO:0012507,GO:0019886,GO:0019898,GO:0030127,GO:0043547,GO:0048208,GO:0048471,GO:0070971,GO:0072659,GO:0090110" Golgi membrane|antigen processing and presentation of peptide antigen via MHC class I|GTPase activator activity|protein binding|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|zinc ion binding|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|extrinsic component of membrane|COPII vesicle coat|positive regulation of GTPase activity|COPII vesicle coating|perinuclear region of cytoplasm|endoplasmic reticulum exit site|protein localization to plasma membrane|COPII-coated vesicle cargo loading hsa04141 Protein processing in endoplasmic reticulum SEC23B 2241.17446 2189.030809 2293.318111 1.047640856 0.067144228 0.777833784 1 33.6961497 34.71074094 10483 "SEC23 homolog B, COPII coat complex component" "GO:0000139,GO:0005096,GO:0005515,GO:0005783,GO:0005789,GO:0005829,GO:0006886,GO:0008270,GO:0012505,GO:0030127,GO:0043547,GO:0048471,GO:0070971,GO:0090110" Golgi membrane|GTPase activator activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|intracellular protein transport|zinc ion binding|endomembrane system|COPII vesicle coat|positive regulation of GTPase activity|perinuclear region of cytoplasm|endoplasmic reticulum exit site|COPII-coated vesicle cargo loading hsa04141 Protein processing in endoplasmic reticulum SEC23IP 996.8314694 1012.322708 981.3402311 0.969394664 -0.044843954 0.859123027 1 11.13016118 10.60897087 11196 SEC23 interacting protein "GO:0000139,GO:0003723,GO:0004620,GO:0005515,GO:0005737,GO:0005783,GO:0005793,GO:0005794,GO:0005829,GO:0006886,GO:0007030,GO:0012507,GO:0030134,GO:0043231,GO:0046872,GO:0048208" Golgi membrane|RNA binding|phospholipase activity|protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|intracellular protein transport|Golgi organization|ER to Golgi transport vesicle membrane|COPII-coated ER to Golgi transport vesicle|intracellular membrane-bounded organelle|metal ion binding|COPII vesicle coating SEC24A 1907.75518 1737.491184 2078.019177 1.195988328 0.25820331 0.27569662 1 11.81834197 13.89807569 10802 "SEC24 homolog A, COPII coat complex component" "GO:0000139,GO:0000149,GO:0002474,GO:0005515,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0008270,GO:0012507,GO:0019886,GO:0030127,GO:0048208,GO:0070971,GO:0090110" Golgi membrane|SNARE binding|antigen processing and presentation of peptide antigen via MHC class I|protein binding|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|zinc ion binding|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|COPII vesicle coat|COPII vesicle coating|endoplasmic reticulum exit site|COPII-coated vesicle cargo loading "hsa04141,hsa05130" Protein processing in endoplasmic reticulum|Pathogenic Escherichia coli infection SEC24B 1334.943287 1347.335978 1322.550595 0.981604156 -0.026786738 0.914396447 1 13.52103137 13.05020661 10427 "SEC24 homolog B, COPII coat complex component" "GO:0000139,GO:0000149,GO:0001843,GO:0002474,GO:0003151,GO:0005515,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0008270,GO:0012507,GO:0019886,GO:0021747,GO:0030127,GO:0035909,GO:0048208,GO:0060088,GO:0060463,GO:0060982,GO:0061156,GO:0070971,GO:0090110,GO:0090178,GO:1901301" Golgi membrane|SNARE binding|neural tube closure|antigen processing and presentation of peptide antigen via MHC class I|outflow tract morphogenesis|protein binding|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|zinc ion binding|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|cochlear nucleus development|COPII vesicle coat|aorta morphogenesis|COPII vesicle coating|auditory receptor cell stereocilium organization|lung lobe morphogenesis|coronary artery morphogenesis|pulmonary artery morphogenesis|endoplasmic reticulum exit site|COPII-coated vesicle cargo loading|regulation of establishment of planar polarity involved in neural tube closure|regulation of cargo loading into COPII-coated vesicle "hsa04141,hsa05130" Protein processing in endoplasmic reticulum|Pathogenic Escherichia coli infection SEC24C 5005.545582 5055.371056 4955.720109 0.980288104 -0.028722279 0.905552022 1 56.02073544 53.99750795 9632 "SEC24 homolog C, COPII coat complex component" "GO:0000139,GO:0000149,GO:0002474,GO:0005515,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0008270,GO:0012507,GO:0019886,GO:0030127,GO:0048208,GO:0070971,GO:0090110" Golgi membrane|SNARE binding|antigen processing and presentation of peptide antigen via MHC class I|protein binding|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|zinc ion binding|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|COPII vesicle coat|COPII vesicle coating|endoplasmic reticulum exit site|COPII-coated vesicle cargo loading "hsa04141,hsa05130" Protein processing in endoplasmic reticulum|Pathogenic Escherichia coli infection SEC24D 2295.379778 2337.809994 2252.949561 0.963700885 -0.053342665 0.823005293 1 28.31055654 26.82636588 9871 "SEC24 homolog D, COPII coat complex component" "GO:0000139,GO:0000149,GO:0001701,GO:0002474,GO:0005515,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0008270,GO:0012507,GO:0019886,GO:0030127,GO:0043231,GO:0048208,GO:0070971,GO:0090110" Golgi membrane|SNARE binding|in utero embryonic development|antigen processing and presentation of peptide antigen via MHC class I|protein binding|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|zinc ion binding|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|COPII vesicle coat|intracellular membrane-bounded organelle|COPII vesicle coating|endoplasmic reticulum exit site|COPII-coated vesicle cargo loading "hsa04141,hsa05130" Protein processing in endoplasmic reticulum|Pathogenic Escherichia coli infection SEC31A 3905.235134 4228.242019 3582.228248 0.847214571 -0.239200693 0.314891439 1 47.95017114 39.94429464 22872 "SEC31 homolog A, COPII coat complex component" "GO:0000139,GO:0002474,GO:0005198,GO:0005515,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0007029,GO:0012507,GO:0019886,GO:0030120,GO:0030127,GO:0030134,GO:0036498,GO:0043231,GO:0048208,GO:0048306,GO:0048471,GO:0051592,GO:0070971,GO:0090110" Golgi membrane|antigen processing and presentation of peptide antigen via MHC class I|structural molecule activity|protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|endoplasmic reticulum organization|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|vesicle coat|COPII vesicle coat|COPII-coated ER to Golgi transport vesicle|IRE1-mediated unfolded protein response|intracellular membrane-bounded organelle|COPII vesicle coating|calcium-dependent protein binding|perinuclear region of cytoplasm|response to calcium ion|endoplasmic reticulum exit site|COPII-coated vesicle cargo loading hsa04141 Protein processing in endoplasmic reticulum SEC31B 372.7279086 398.4785171 346.9773001 0.870755349 -0.199660665 0.501954799 1 4.589138127 3.929148645 25956 "SEC31 homolog B, COPII coat complex component" "GO:0000139,GO:0005198,GO:0005789,GO:0006886,GO:0007029,GO:0030120,GO:0030127,GO:0070971,GO:0090110" Golgi membrane|structural molecule activity|endoplasmic reticulum membrane|intracellular protein transport|endoplasmic reticulum organization|vesicle coat|COPII vesicle coat|endoplasmic reticulum exit site|COPII-coated vesicle cargo loading hsa04141 Protein processing in endoplasmic reticulum SEC61A1 6099.417976 6256.008676 5942.827276 0.949939104 -0.074093063 0.760264218 1 93.57390275 87.40206376 29927 SEC61 translocon subunit alpha 1 "GO:0005048,GO:0005262,GO:0005515,GO:0005784,GO:0005789,GO:0005829,GO:0006613,GO:0006614,GO:0006616,GO:0006620,GO:0007029,GO:0008320,GO:0016020,GO:0030176,GO:0031204,GO:0039019,GO:0043022,GO:0045047,GO:0070588" "signal sequence binding|calcium channel activity|protein binding|Sec61 translocon complex|endoplasmic reticulum membrane|cytosol|cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane, translocation|posttranslational protein targeting to endoplasmic reticulum membrane|endoplasmic reticulum organization|protein transmembrane transporter activity|membrane|integral component of endoplasmic reticulum membrane|posttranslational protein targeting to membrane, translocation|pronephric nephron development|ribosome binding|protein targeting to ER|calcium ion transmembrane transport" "hsa03060,hsa04141,hsa04145,hsa05110" Protein export|Protein processing in endoplasmic reticulum|Phagosome|Vibrio cholerae infection SEC61A2 185.3483853 185.1936711 185.5030995 1.001670837 0.002408496 1 1 3.057996861 3.01184934 55176 SEC61 translocon subunit alpha 2 "GO:0003674,GO:0005048,GO:0005784,GO:0005829,GO:0006616,GO:0008150,GO:0008320,GO:0016021,GO:0031204,GO:0043022" "molecular_function|signal sequence binding|Sec61 translocon complex|cytosol|SRP-dependent cotranslational protein targeting to membrane, translocation|biological_process|protein transmembrane transporter activity|integral component of membrane|posttranslational protein targeting to membrane, translocation|ribosome binding" "hsa03060,hsa04141,hsa04145,hsa05110" Protein export|Protein processing in endoplasmic reticulum|Phagosome|Vibrio cholerae infection SEC61B 901.3215979 801.1186896 1001.524506 1.25015746 0.322109817 0.194687003 1 75.80537601 93.18283121 10952 SEC61 translocon subunit beta "GO:0003723,GO:0005515,GO:0005783,GO:0005784,GO:0005789,GO:0005829,GO:0006616,GO:0016020,GO:0016021,GO:0030433,GO:0030970,GO:0031204,GO:0031205,GO:0044322,GO:0048408,GO:0050790" "RNA binding|protein binding|endoplasmic reticulum|Sec61 translocon complex|endoplasmic reticulum membrane|cytosol|SRP-dependent cotranslational protein targeting to membrane, translocation|membrane|integral component of membrane|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|posttranslational protein targeting to membrane, translocation|endoplasmic reticulum Sec complex|endoplasmic reticulum quality control compartment|epidermal growth factor binding|regulation of catalytic activity" "hsa03060,hsa04141,hsa04145,hsa05110" Protein export|Protein processing in endoplasmic reticulum|Phagosome|Vibrio cholerae infection SEC61G 1241.09906 977.9890497 1504.209071 1.538063306 0.621114885 0.010252678 0.610531935 122.8081838 185.725997 23480 SEC61 translocon subunit gamma "GO:0005515,GO:0005789,GO:0005829,GO:0008320,GO:0015450,GO:0016020,GO:0016021,GO:0031204,GO:0045047,GO:0071261" "protein binding|endoplasmic reticulum membrane|cytosol|protein transmembrane transporter activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|membrane|integral component of membrane|posttranslational protein targeting to membrane, translocation|protein targeting to ER|Ssh1 translocon complex" "hsa03060,hsa04141,hsa04145,hsa05110" Protein export|Protein processing in endoplasmic reticulum|Phagosome|Vibrio cholerae infection SEC62 2113.727561 2123.484734 2103.970388 0.990810225 -0.013319338 0.957245494 1 15.53694509 15.13656357 7095 "SEC62 homolog, preprotein translocation factor" "GO:0005783,GO:0005789,GO:0005791,GO:0005829,GO:0006613,GO:0006620,GO:0016020,GO:0016021,GO:0030176,GO:0031204,GO:0038023" "endoplasmic reticulum|endoplasmic reticulum membrane|rough endoplasmic reticulum|cytosol|cotranslational protein targeting to membrane|posttranslational protein targeting to endoplasmic reticulum membrane|membrane|integral component of membrane|integral component of endoplasmic reticulum membrane|posttranslational protein targeting to membrane, translocation|signaling receptor activity" "hsa03060,hsa04141" Protein export|Protein processing in endoplasmic reticulum SEC63 1675.458608 1581.429102 1769.488115 1.118917132 0.162103193 0.495865077 1 13.32880048 14.66426057 11231 "SEC63 homolog, protein translocation regulator" "GO:0001889,GO:0003723,GO:0005515,GO:0005783,GO:0005789,GO:0005829,GO:0006612,GO:0006614,GO:0006620,GO:0006807,GO:0008320,GO:0010259,GO:0016020,GO:0016021,GO:0031204,GO:0031207,GO:0038023" "liver development|RNA binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane|posttranslational protein targeting to endoplasmic reticulum membrane|nitrogen compound metabolic process|protein transmembrane transporter activity|multicellular organism aging|membrane|integral component of membrane|posttranslational protein targeting to membrane, translocation|Sec62/Sec63 complex|signaling receptor activity" "hsa03060,hsa04141" Protein export|Protein processing in endoplasmic reticulum SECISBP2 889.7028237 912.4429751 866.9626723 0.950155457 -0.073764519 0.77031583 1 9.829512431 9.183279909 79048 SECIS binding protein 2 "GO:0001514,GO:0003723,GO:0003730,GO:0005515,GO:0005654,GO:0005739,GO:0021756,GO:0035368,GO:0043021,GO:0048666,GO:1990904,GO:2000623" "selenocysteine incorporation|RNA binding|mRNA 3'-UTR binding|protein binding|nucleoplasm|mitochondrion|striatum development|selenocysteine insertion sequence binding|ribonucleoprotein complex binding|neuron development|ribonucleoprotein complex|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" SECISBP2L 1532.895526 1560.620824 1505.170227 0.964468886 -0.052193398 0.82909741 1 11.79876258 11.18911822 9728 SECIS binding protein 2 like "GO:0001514,GO:0003723,GO:0003730,GO:0005515,GO:0035368,GO:0043021,GO:1990904" selenocysteine incorporation|RNA binding|mRNA 3'-UTR binding|protein binding|selenocysteine insertion sequence binding|ribonucleoprotein complex binding|ribonucleoprotein complex SECTM1 333.083355 291.3158871 374.8508228 1.286750361 0.363732187 0.233450101 1 6.194021307 7.836789331 6398 secreted and transmembrane 1 "GO:0005125,GO:0005515,GO:0005615,GO:0005794,GO:0005886,GO:0006955,GO:0007165,GO:0007498,GO:0016021,GO:0043123,GO:0070062" cytokine activity|protein binding|extracellular space|Golgi apparatus|plasma membrane|immune response|signal transduction|mesoderm development|integral component of membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|extracellular exosome SEH1L 1142.218269 1082.030438 1202.406101 1.111249794 0.152183151 0.532741258 1 14.05353511 15.35565885 81929 SEH1 like nucleoporin "GO:0000776,GO:0000777,GO:0005198,GO:0005515,GO:0005635,GO:0005765,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006999,GO:0007080,GO:0016032,GO:0016925,GO:0019083,GO:0031080,GO:0032008,GO:0034198,GO:0034629,GO:0035859,GO:0043657,GO:0050830,GO:0051301,GO:0051315,GO:0060964,GO:0061700,GO:0075733,GO:1900034,GO:1904263" kinetochore|condensed chromosome kinetochore|structural molecule activity|protein binding|nuclear envelope|lysosomal membrane|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|nuclear pore organization|mitotic metaphase plate congression|viral process|protein sumoylation|viral transcription|nuclear pore outer ring|positive regulation of TOR signaling|cellular response to amino acid starvation|cellular protein-containing complex localization|Seh1-associated complex|host cell|defense response to Gram-positive bacterium|cell division|attachment of mitotic spindle microtubules to kinetochore|regulation of gene silencing by miRNA|GATOR2 complex|intracellular transport of virus|regulation of cellular response to heat|positive regulation of TORC1 signaling "hsa03013,hsa04150,hsa05014" RNA transport|mTOR signaling pathway|Amyotrophic lateral sclerosis SEL1L 3194.947026 3219.040553 3170.853499 0.985030616 -0.021759529 0.928175654 1 20.04600676 19.41550899 6400 SEL1L adaptor subunit of ERAD E3 ubiquitin ligase "GO:0000836,GO:0000839,GO:0004842,GO:0005515,GO:0005783,GO:0005789,GO:0006641,GO:0007219,GO:0009306,GO:0016021,GO:0016567,GO:0030433,GO:0030970,GO:0036503,GO:0036513,GO:0044322,GO:0050821,GO:0055085,GO:1904380" "Hrd1p ubiquitin ligase complex|Hrd1p ubiquitin ligase ERAD-L complex|ubiquitin-protein transferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|triglyceride metabolic process|Notch signaling pathway|protein secretion|integral component of membrane|protein ubiquitination|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|ERAD pathway|Derlin-1 retrotranslocation complex|endoplasmic reticulum quality control compartment|protein stabilization|transmembrane transport|endoplasmic reticulum mannose trimming" hsa04141 Protein processing in endoplasmic reticulum SEL1L3 356.496469 527.4898385 185.5030995 0.351671418 -1.50770001 7.60E-07 0.000577584 3.863203403 1.335844252 23231 SEL1L family member 3 "GO:0005654,GO:0016021" nucleoplasm|integral component of membrane SELENOF 2745.650546 2513.63994 2977.661152 1.184601304 0.24440158 0.301559858 1 86.99633187 101.3314661 9403 selenoprotein F "GO:0005515,GO:0005788,GO:0016491,GO:0051084,GO:0055114" protein binding|endoplasmic reticulum lumen|oxidoreductase activity|'de novo' posttranslational protein folding|oxidation-reduction process SELENOH 860.7102435 807.3611729 914.0593141 1.132156642 0.179073579 0.47454239 1 36.76397776 40.92608406 280636 selenoprotein H "GO:0003723,GO:0005794" RNA binding|Golgi apparatus SELENOI 1237.886657 1297.396112 1178.377202 0.908263245 -0.138817596 0.566952227 1 8.584136619 7.666189303 85465 selenoprotein I "GO:0004307,GO:0005789,GO:0005794,GO:0006646,GO:0016021,GO:0046872" ethanolaminephosphotransferase activity|endoplasmic reticulum membrane|Golgi apparatus|phosphatidylethanolamine biosynthetic process|integral component of membrane|metal ion binding "hsa00440,hsa00564,hsa00565" Phosphonate and phosphinate metabolism|Glycerophospholipid metabolism|Ether lipid metabolism SELENOK 536.1143603 423.4484502 648.7802703 1.532135187 0.615543598 0.022270446 0.822216713 15.09596895 22.74203163 58515 selenoprotein K "GO:0002230,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0006816,GO:0006979,GO:0010742,GO:0016021,GO:0018345,GO:0032469,GO:0032755,GO:0032760,GO:0042102,GO:0042802,GO:0045728,GO:0050848,GO:0051223,GO:0070059,GO:0071639,GO:2000406" positive regulation of defense response to virus by host|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|calcium ion transport|response to oxidative stress|macrophage derived foam cell differentiation|integral component of membrane|protein palmitoylation|endoplasmic reticulum calcium ion homeostasis|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of T cell proliferation|identical protein binding|respiratory burst after phagocytosis|regulation of calcium-mediated signaling|regulation of protein transport|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|positive regulation of monocyte chemotactic protein-1 production|positive regulation of T cell migration SELENOM 54.08201461 57.22276355 50.94126567 0.890227289 -0.167754369 0.80028609 1 4.400394408 3.851799618 140606 selenoprotein M "GO:0005515,GO:0005788,GO:0005794,GO:0010269,GO:0016491,GO:0035264,GO:0035934,GO:0042445,GO:0048471,GO:0055114,GO:0060612" protein binding|endoplasmic reticulum lumen|Golgi apparatus|response to selenium ion|oxidoreductase activity|multicellular organism growth|corticosterone secretion|hormone metabolic process|perinuclear region of cytoplasm|oxidation-reduction process|adipose tissue development SELENON 3140.993345 3240.889244 3041.097445 0.938352784 -0.091797673 0.699148032 1 40.09279149 36.99164297 57190 selenoprotein N "GO:0005509,GO:0005515,GO:0005789,GO:0016491,GO:0048741,GO:0055074,GO:0055114,GO:0060314,GO:1902884" calcium ion binding|protein binding|endoplasmic reticulum membrane|oxidoreductase activity|skeletal muscle fiber development|calcium ion homeostasis|oxidation-reduction process|regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of response to oxidative stress SELENOO 612.9861007 574.3084632 651.6637382 1.134692904 0.182301896 0.488772446 1 13.42522433 14.97859468 83642 selenoprotein O "GO:0005524,GO:0005694,GO:0005739,GO:0018117,GO:0046872,GO:0070733" ATP binding|chromosome|mitochondrion|protein adenylylation|metal ion binding|protein adenylyltransferase activity SELENOP 21.62097859 12.48496659 30.75699059 2.463522058 1.300722389 0.11989425 1 0.306626655 0.74274124 6414 selenoprotein P "GO:0001887,GO:0002576,GO:0005576,GO:0006979,GO:0008430,GO:0031089,GO:0070062" selenium compound metabolic process|platelet degranulation|extracellular region|response to oxidative stress|selenium binding|platelet dense granule lumen|extracellular exosome SELENOS 868.1768087 763.6637899 972.6898275 1.273714743 0.349042212 0.1615372 1 19.83227879 24.83796284 55829 selenoprotein S "GO:0002865,GO:0005515,GO:0005783,GO:0005789,GO:0005881,GO:0005886,GO:0006111,GO:0006983,GO:0009749,GO:0016209,GO:0016567,GO:0019899,GO:0030176,GO:0030433,GO:0030968,GO:0030970,GO:0032715,GO:0032720,GO:0032869,GO:0034361,GO:0034362,GO:0034599,GO:0036502,GO:0036513,GO:0038023,GO:0045184,GO:0045454,GO:0045719,GO:0046325,GO:0050728,GO:0051117,GO:0051771,GO:0051775,GO:0071222,GO:0080164,GO:0098869,GO:1902236,GO:1990381,GO:2000110" "negative regulation of acute inflammatory response to antigenic stimulus|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytoplasmic microtubule|plasma membrane|regulation of gluconeogenesis|ER overload response|response to glucose|antioxidant activity|protein ubiquitination|enzyme binding|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|retrograde protein transport, ER to cytosol|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|cellular response to insulin stimulus|very-low-density lipoprotein particle|low-density lipoprotein particle|cellular response to oxidative stress|Derlin-1-VIMP complex|Derlin-1 retrotranslocation complex|signaling receptor activity|establishment of protein localization|cell redox homeostasis|negative regulation of glycogen biosynthetic process|negative regulation of glucose import|negative regulation of inflammatory response|ATPase binding|negative regulation of nitric-oxide synthase biosynthetic process|response to redox state|cellular response to lipopolysaccharide|regulation of nitric oxide metabolic process|cellular oxidant detoxification|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|ubiquitin-specific protease binding|negative regulation of macrophage apoptotic process" hsa04141 Protein processing in endoplasmic reticulum SELENOT 1526.975719 1443.054055 1610.897382 1.116311185 0.158739251 0.506548163 1 22.40708254 24.59471355 51714 selenoprotein T "GO:0001514,GO:0004791,GO:0005783,GO:0005789,GO:0007204,GO:0008430,GO:0009749,GO:0016021,GO:0031016,GO:0035773,GO:0042593,GO:0045454,GO:0055114,GO:0060124,GO:0098869" selenocysteine incorporation|thioredoxin-disulfide reductase activity|endoplasmic reticulum|endoplasmic reticulum membrane|positive regulation of cytosolic calcium ion concentration|selenium binding|response to glucose|integral component of membrane|pancreas development|insulin secretion involved in cellular response to glucose stimulus|glucose homeostasis|cell redox homeostasis|oxidation-reduction process|positive regulation of growth hormone secretion|cellular oxidant detoxification SELENOW 674.2969066 581.5913604 767.0024529 1.318799599 0.399225353 0.121361783 1 40.94783903 53.09834346 6415 selenoprotein W "GO:0005829,GO:0010269,GO:0016209,GO:0098869" cytosol|response to selenium ion|antioxidant activity|cellular oxidant detoxification SELPLG 41.79519283 37.45489978 46.13548589 1.231761029 0.300722389 0.662769552 1 0.714913863 0.865867337 6404 selectin P ligand "GO:0001618,GO:0001931,GO:0005102,GO:0005515,GO:0005886,GO:0005887,GO:0007155,GO:0016020,GO:0016021,GO:0030097,GO:0044853,GO:0046718,GO:0050900,GO:0050901,GO:0050902,GO:0071354" virus receptor activity|uropod|signaling receptor binding|protein binding|plasma membrane|integral component of plasma membrane|cell adhesion|membrane|integral component of membrane|hemopoiesis|plasma membrane raft|viral entry into host cell|leukocyte migration|leukocyte tethering or rolling|leukocyte adhesive activation|cellular response to interleukin-6 "hsa04514,hsa05150" Cell adhesion molecules|Staphylococcus aureus infection SEM1 1034.054855 866.6647642 1201.444945 1.386285672 0.471224584 0.054620554 1 27.81257102 37.91098343 7979 SEM1 26S proteasome complex subunit "hsa03050,hsa03440,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05169" Proteasome|Homologous recombination|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Epstein-Barr virus infection SEMA3A 1179.271849 1159.021065 1199.522633 1.034944635 0.049553592 0.841245461 1 6.739466557 6.858257998 10371 semaphorin 3A "GO:0001755,GO:0001764,GO:0002027,GO:0005576,GO:0005615,GO:0005887,GO:0006915,GO:0007411,GO:0007413,GO:0008045,GO:0010633,GO:0010977,GO:0021612,GO:0021637,GO:0021675,GO:0021772,GO:0021785,GO:0021828,GO:0030215,GO:0030335,GO:0030424,GO:0030425,GO:0036486,GO:0038191,GO:0045499,GO:0046330,GO:0048485,GO:0048841,GO:0048843,GO:0048846,GO:0048880,GO:0050919,GO:0060385,GO:0060666,GO:0061549,GO:0061551,GO:0071526,GO:0097490,GO:0097491,GO:0150020,GO:1901166,GO:1902285,GO:1902287,GO:1903045,GO:1903375,GO:2000020,GO:2001224" neural crest cell migration|neuron migration|regulation of heart rate|extracellular region|extracellular space|integral component of plasma membrane|apoptotic process|axon guidance|axonal fasciculation|motor neuron axon guidance|negative regulation of epithelial cell migration|negative regulation of neuron projection development|facial nerve structural organization|trigeminal nerve structural organization|nerve development|olfactory bulb development|branchiomotor neuron axon guidance|gonadotrophin-releasing hormone neuronal migration to the hypothalamus|semaphorin receptor binding|positive regulation of cell migration|axon|dendrite|ventral trunk neural crest cell migration|neuropilin binding|chemorepellent activity|positive regulation of JNK cascade|sympathetic nervous system development|regulation of axon extension involved in axon guidance|negative regulation of axon extension involved in axon guidance|axon extension involved in axon guidance|sensory system development|negative chemotaxis|axonogenesis involved in innervation|dichotomous subdivision of terminal units involved in salivary gland branching|sympathetic ganglion development|trigeminal ganglion development|semaphorin-plexin signaling pathway|sympathetic neuron projection extension|sympathetic neuron projection guidance|basal dendrite arborization|neural crest cell migration involved in autonomic nervous system development|semaphorin-plexin signaling pathway involved in neuron projection guidance|semaphorin-plexin signaling pathway involved in axon guidance|neural crest cell migration involved in sympathetic nervous system development|facioacoustic ganglion development|positive regulation of male gonad development|positive regulation of neuron migration hsa04360 Axon guidance SEMA3B 88.10367145 105.0818021 71.12554074 0.676858783 -0.563073227 0.251238811 1 1.618009997 1.076838187 7869 semaphorin 3B "GO:0001755,GO:0005615,GO:0005783,GO:0005887,GO:0007267,GO:0007411,GO:0030215,GO:0030335,GO:0045499,GO:0048843,GO:0050919,GO:0061643,GO:0062023,GO:0071526" neural crest cell migration|extracellular space|endoplasmic reticulum|integral component of plasma membrane|cell-cell signaling|axon guidance|semaphorin receptor binding|positive regulation of cell migration|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|chemorepulsion of axon|collagen-containing extracellular matrix|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA3C 5870.397475 6715.871612 5024.923338 0.748216111 -0.418473064 0.083892022 1 70.45679668 51.83476428 10512 semaphorin 3C "GO:0001755,GO:0001756,GO:0001974,GO:0003148,GO:0003215,GO:0003350,GO:0005615,GO:0005887,GO:0006955,GO:0007411,GO:0009791,GO:0021915,GO:0030215,GO:0030335,GO:0042493,GO:0045499,GO:0048843,GO:0050919,GO:0060174,GO:0060666,GO:0070062,GO:0071526,GO:0140074,GO:1905312" neural crest cell migration|somitogenesis|blood vessel remodeling|outflow tract septum morphogenesis|cardiac right ventricle morphogenesis|pulmonary myocardium development|extracellular space|integral component of plasma membrane|immune response|axon guidance|post-embryonic development|neural tube development|semaphorin receptor binding|positive regulation of cell migration|response to drug|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|limb bud formation|dichotomous subdivision of terminal units involved in salivary gland branching|extracellular exosome|semaphorin-plexin signaling pathway|cardiac endothelial to mesenchymal transition|positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis hsa04360 Axon guidance SEMA3D 232.9847414 237.2143652 228.7551175 0.964339227 -0.052387361 0.891245594 1 1.613316515 1.529750455 223117 semaphorin 3D "GO:0001755,GO:0005615,GO:0005887,GO:0007411,GO:0030215,GO:0030335,GO:0045499,GO:0048843,GO:0050919,GO:0071526" neural crest cell migration|extracellular space|integral component of plasma membrane|axon guidance|semaphorin receptor binding|positive regulation of cell migration|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA3E 212.7413301 185.1936711 240.288989 1.297501084 0.375735744 0.291820856 1 1.340491775 1.710184876 9723 semaphorin 3E "GO:0001569,GO:0001755,GO:0001953,GO:0002040,GO:0005515,GO:0005576,GO:0005615,GO:0005887,GO:0007411,GO:0008360,GO:0016525,GO:0030215,GO:0030335,GO:0045499,GO:0048843,GO:0050808,GO:0050919,GO:0071526,GO:2000249" branching involved in blood vessel morphogenesis|neural crest cell migration|negative regulation of cell-matrix adhesion|sprouting angiogenesis|protein binding|extracellular region|extracellular space|integral component of plasma membrane|axon guidance|regulation of cell shape|negative regulation of angiogenesis|semaphorin receptor binding|positive regulation of cell migration|chemorepellent activity|negative regulation of axon extension involved in axon guidance|synapse organization|negative chemotaxis|semaphorin-plexin signaling pathway|regulation of actin cytoskeleton reorganization hsa04360 Axon guidance SEMA3F 112.8855206 124.8496659 100.9213754 0.808343175 -0.306960188 0.501233269 1 1.406882856 1.118213914 6405 semaphorin 3F "GO:0001755,GO:0005615,GO:0005887,GO:0007411,GO:0021612,GO:0021637,GO:0021675,GO:0021785,GO:0030215,GO:0030335,GO:0036486,GO:0045499,GO:0048843,GO:0048846,GO:0050919,GO:0061549,GO:0071526,GO:0097490,GO:0097491,GO:0098978,GO:0099175,GO:1901166,GO:1902285,GO:1902287" neural crest cell migration|extracellular space|integral component of plasma membrane|axon guidance|facial nerve structural organization|trigeminal nerve structural organization|nerve development|branchiomotor neuron axon guidance|semaphorin receptor binding|positive regulation of cell migration|ventral trunk neural crest cell migration|chemorepellent activity|negative regulation of axon extension involved in axon guidance|axon extension involved in axon guidance|negative chemotaxis|sympathetic ganglion development|semaphorin-plexin signaling pathway|sympathetic neuron projection extension|sympathetic neuron projection guidance|glutamatergic synapse|regulation of postsynapse organization|neural crest cell migration involved in autonomic nervous system development|semaphorin-plexin signaling pathway involved in neuron projection guidance|semaphorin-plexin signaling pathway involved in axon guidance hsa04360 Axon guidance SEMA3G 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.032939476 0 56920 semaphorin 3G "GO:0001755,GO:0005102,GO:0005515,GO:0005615,GO:0005887,GO:0007411,GO:0030215,GO:0030335,GO:0030517,GO:0045499,GO:0048843,GO:0050919,GO:0070062,GO:0071526" neural crest cell migration|signaling receptor binding|protein binding|extracellular space|integral component of plasma membrane|axon guidance|semaphorin receptor binding|positive regulation of cell migration|negative regulation of axon extension|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|extracellular exosome|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA4A 4.92466667 3.121241648 6.728091692 2.155581801 1.108077311 0.568402303 1 0.045301858 0.096017788 64218 semaphorin 4A "GO:0001525,GO:0001755,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0007411,GO:0008360,GO:0010594,GO:0016525,GO:0030215,GO:0030335,GO:0045063,GO:0045499,GO:0048843,GO:0050919,GO:0071526,GO:1904891,GO:1905704" angiogenesis|neural crest cell migration|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|axon guidance|regulation of cell shape|regulation of endothelial cell migration|negative regulation of angiogenesis|semaphorin receptor binding|positive regulation of cell migration|T-helper 1 cell differentiation|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|semaphorin-plexin signaling pathway|positive regulation of excitatory synapse assembly|positive regulation of inhibitory synapse assembly hsa04360 Axon guidance SEMA4B 5414.301018 4797.348413 6031.253624 1.25720567 0.330220683 0.170623266 1 62.52153056 77.2871176 10509 semaphorin 4B "GO:0001755,GO:0005615,GO:0005887,GO:0007411,GO:0030215,GO:0030335,GO:0045202,GO:0045499,GO:0048843,GO:0050919,GO:0071526" neural crest cell migration|extracellular space|integral component of plasma membrane|axon guidance|semaphorin receptor binding|positive regulation of cell migration|synapse|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA4C 684.9482657 684.5923348 685.3041966 1.001039833 0.001499383 1 1 7.534632848 7.416254629 54910 semaphorin 4C "GO:0001755,GO:0001843,GO:0005515,GO:0005615,GO:0005887,GO:0007411,GO:0014069,GO:0021535,GO:0021549,GO:0030215,GO:0030335,GO:0030672,GO:0032874,GO:0042692,GO:0045499,GO:0048843,GO:0050919,GO:0071526,GO:0098839" neural crest cell migration|neural tube closure|protein binding|extracellular space|integral component of plasma membrane|axon guidance|postsynaptic density|cell migration in hindbrain|cerebellum development|semaphorin receptor binding|positive regulation of cell migration|synaptic vesicle membrane|positive regulation of stress-activated MAPK cascade|muscle cell differentiation|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|semaphorin-plexin signaling pathway|postsynaptic density membrane hsa04360 Axon guidance SEMA4D 38.83246704 35.37407201 42.29086206 1.195532763 0.257653667 0.724474736 1 0.15018689 0.176548766 10507 semaphorin 4D "GO:0000122,GO:0001755,GO:0001934,GO:0004888,GO:0005102,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0006955,GO:0007155,GO:0007162,GO:0007411,GO:0008360,GO:0010693,GO:0014068,GO:0030215,GO:0030335,GO:0031344,GO:0038023,GO:0043066,GO:0043547,GO:0043931,GO:0045499,GO:0045668,GO:0048672,GO:0048814,GO:0048843,GO:0050731,GO:0050732,GO:0050919,GO:0070486,GO:0071526,GO:1900220,GO:1905704" negative regulation of transcription by RNA polymerase II|neural crest cell migration|positive regulation of protein phosphorylation|transmembrane signaling receptor activity|signaling receptor binding|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|immune response|cell adhesion|negative regulation of cell adhesion|axon guidance|regulation of cell shape|negative regulation of alkaline phosphatase activity|positive regulation of phosphatidylinositol 3-kinase signaling|semaphorin receptor binding|positive regulation of cell migration|regulation of cell projection organization|signaling receptor activity|negative regulation of apoptotic process|positive regulation of GTPase activity|ossification involved in bone maturation|chemorepellent activity|negative regulation of osteoblast differentiation|positive regulation of collateral sprouting|regulation of dendrite morphogenesis|negative regulation of axon extension involved in axon guidance|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of peptidyl-tyrosine phosphorylation|negative chemotaxis|leukocyte aggregation|semaphorin-plexin signaling pathway|semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis|positive regulation of inhibitory synapse assembly hsa04360 Axon guidance SEMA4F 750.5245228 740.7746844 760.2743612 1.026323357 0.037485344 0.88776405 1 4.195456163 4.233841339 10505 ssemaphorin 4F "GO:0001755,GO:0005615,GO:0005783,GO:0005886,GO:0005887,GO:0007267,GO:0007399,GO:0007411,GO:0014069,GO:0016020,GO:0030215,GO:0030335,GO:0030425,GO:0031290,GO:0043204,GO:0045211,GO:0045499,GO:0048843,GO:0050919,GO:0071526" neural crest cell migration|extracellular space|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|cell-cell signaling|nervous system development|axon guidance|postsynaptic density|membrane|semaphorin receptor binding|positive regulation of cell migration|dendrite|retinal ganglion cell axon guidance|perikaryon|postsynaptic membrane|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA4G 402.9791691 460.90335 345.0549882 0.748649339 -0.417637965 0.147721266 1 5.208038257 3.833750006 57715 semaphorin 4G "GO:0001755,GO:0005515,GO:0005615,GO:0005887,GO:0007411,GO:0030215,GO:0030335,GO:0045499,GO:0048843,GO:0050919,GO:0071526" neural crest cell migration|protein binding|extracellular space|integral component of plasma membrane|axon guidance|semaphorin receptor binding|positive regulation of cell migration|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA5A 43.71247433 49.93986637 37.48508228 0.750604377 -0.413875392 0.526027801 1 0.166211343 0.122671289 9037 semaphorin 5A "GO:0001755,GO:0001938,GO:0002043,GO:0005886,GO:0007155,GO:0007162,GO:0007267,GO:0007399,GO:0007411,GO:0007413,GO:0016020,GO:0016021,GO:0021536,GO:0030215,GO:0030335,GO:0030836,GO:0035373,GO:0043395,GO:0045499,GO:0045545,GO:0045766,GO:0048675,GO:0048842,GO:0048843,GO:0050918,GO:0050919,GO:0051897,GO:0060326,GO:0070062,GO:0071526,GO:0090263,GO:1990256,GO:2000352,GO:2001028" neural crest cell migration|positive regulation of endothelial cell proliferation|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|plasma membrane|cell adhesion|negative regulation of cell adhesion|cell-cell signaling|nervous system development|axon guidance|axonal fasciculation|membrane|integral component of membrane|diencephalon development|semaphorin receptor binding|positive regulation of cell migration|positive regulation of actin filament depolymerization|chondroitin sulfate proteoglycan binding|heparan sulfate proteoglycan binding|chemorepellent activity|syndecan binding|positive regulation of angiogenesis|axon extension|positive regulation of axon extension involved in axon guidance|negative regulation of axon extension involved in axon guidance|positive chemotaxis|negative chemotaxis|positive regulation of protein kinase B signaling|cell chemotaxis|extracellular exosome|semaphorin-plexin signaling pathway|positive regulation of canonical Wnt signaling pathway|signal clustering|negative regulation of endothelial cell apoptotic process|positive regulation of endothelial cell chemotaxis hsa04360 Axon guidance SEMA6A 107.2525631 90.51600779 123.9891183 1.369803213 0.45396865 0.323666468 1 0.60954864 0.820989733 57556 semaphorin 6A "GO:0001755,GO:0005515,GO:0005615,GO:0005887,GO:0006915,GO:0007010,GO:0007166,GO:0007399,GO:0007411,GO:0009887,GO:0016021,GO:0016525,GO:0030215,GO:0030335,GO:0030424,GO:0035924,GO:0045499,GO:0048843,GO:0050919,GO:0070373,GO:0071526,GO:0106089,GO:1900747,GO:1903671,GO:2001224" neural crest cell migration|protein binding|extracellular space|integral component of plasma membrane|apoptotic process|cytoskeleton organization|cell surface receptor signaling pathway|nervous system development|axon guidance|animal organ morphogenesis|integral component of membrane|negative regulation of angiogenesis|semaphorin receptor binding|positive regulation of cell migration|axon|cellular response to vascular endothelial growth factor stimulus|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|negative regulation of ERK1 and ERK2 cascade|semaphorin-plexin signaling pathway|negative regulation of cell adhesion involved in sprouting angiogenesis|negative regulation of vascular endothelial growth factor signaling pathway|negative regulation of sprouting angiogenesis|positive regulation of neuron migration hsa04360 Axon guidance SEMA6B 254.0754522 273.6288511 234.5220533 0.857080868 -0.222496762 0.508939801 1 3.62899326 3.058293354 10501 semaphorin 6B "GO:0001755,GO:0005515,GO:0005615,GO:0005887,GO:0007411,GO:0030215,GO:0030335,GO:0045499,GO:0048843,GO:0050919,GO:0071526" neural crest cell migration|protein binding|extracellular space|integral component of plasma membrane|axon guidance|semaphorin receptor binding|positive regulation of cell migration|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA6C 193.438953 183.1128433 203.7650627 1.112784111 0.154173726 0.685076034 1 1.472411617 1.611058572 10500 semaphorin 6C "GO:0001755,GO:0005615,GO:0005887,GO:0007411,GO:0030215,GO:0030335,GO:0045499,GO:0048843,GO:0050919,GO:0071526" neural crest cell migration|extracellular space|integral component of plasma membrane|axon guidance|semaphorin receptor binding|positive regulation of cell migration|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA6D 148.6068069 129.0113214 168.2022923 1.303779315 0.382699692 0.35052617 1 0.716973562 0.9191331 80031 semaphorin 6D "GO:0001755,GO:0005615,GO:0005794,GO:0005886,GO:0005887,GO:0007411,GO:0014911,GO:0014912,GO:0021591,GO:0030215,GO:0030335,GO:0045499,GO:0048843,GO:0050919,GO:0071526" neural crest cell migration|extracellular space|Golgi apparatus|plasma membrane|integral component of plasma membrane|axon guidance|positive regulation of smooth muscle cell migration|negative regulation of smooth muscle cell migration|ventricular system development|semaphorin receptor binding|positive regulation of cell migration|chemorepellent activity|negative regulation of axon extension involved in axon guidance|negative chemotaxis|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA7A 2964.382723 2540.690701 3388.074745 1.33352507 0.415244947 0.07956609 1 38.8404449 50.92799272 8482 semaphorin 7A (John Milton Hagen blood group) "GO:0001649,GO:0001755,GO:0001934,GO:0005178,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0007229,GO:0007411,GO:0009897,GO:0016020,GO:0021988,GO:0030215,GO:0030335,GO:0031225,GO:0045499,GO:0045773,GO:0048675,GO:0048843,GO:0050727,GO:0050919,GO:0060907,GO:0062023,GO:0070374,GO:0071526" osteoblast differentiation|neural crest cell migration|positive regulation of protein phosphorylation|integrin binding|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|integrin-mediated signaling pathway|axon guidance|external side of plasma membrane|membrane|olfactory lobe development|semaphorin receptor binding|positive regulation of cell migration|anchored component of membrane|chemorepellent activity|positive regulation of axon extension|axon extension|negative regulation of axon extension involved in axon guidance|regulation of inflammatory response|negative chemotaxis|positive regulation of macrophage cytokine production|collagen-containing extracellular matrix|positive regulation of ERK1 and ERK2 cascade|semaphorin-plexin signaling pathway hsa04360 Axon guidance SENP1 810.4326094 850.0181421 770.8470767 0.906859558 -0.141048952 0.576883556 1 8.95458073 7.984660765 29843 SUMO specific peptidase 1 "GO:0004175,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005925,GO:0006508,GO:0006919,GO:0016925,GO:0016926,GO:0016929,GO:0031965,GO:0045944,GO:0070140,GO:0097190" endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|focal adhesion|proteolysis|activation of cysteine-type endopeptidase activity involved in apoptotic process|protein sumoylation|protein desumoylation|SUMO-specific protease activity|nuclear membrane|positive regulation of transcription by RNA polymerase II|SUMO-specific isopeptidase activity|apoptotic signaling pathway SENP2 1103.549349 1038.333055 1168.765642 1.125617293 0.170716398 0.484968187 1 18.16850058 20.10856236 59343 SUMO specific peptidase 2 "GO:0001934,GO:0005515,GO:0005634,GO:0005643,GO:0005654,GO:0005829,GO:0007507,GO:0009950,GO:0015031,GO:0016055,GO:0016605,GO:0016925,GO:0016926,GO:0016929,GO:0019904,GO:0030111,GO:0031397,GO:0031398,GO:0031648,GO:0031965,GO:0032091,GO:0032875,GO:0035562,GO:0045444,GO:0045944,GO:0051028,GO:0060707,GO:0060711,GO:0070139,GO:0070140,GO:2000045" positive regulation of protein phosphorylation|protein binding|nucleus|nuclear pore|nucleoplasm|cytosol|heart development|dorsal/ventral axis specification|protein transport|Wnt signaling pathway|PML body|protein sumoylation|protein desumoylation|SUMO-specific protease activity|protein domain specific binding|regulation of Wnt signaling pathway|negative regulation of protein ubiquitination|positive regulation of protein ubiquitination|protein destabilization|nuclear membrane|negative regulation of protein binding|regulation of DNA endoreduplication|negative regulation of chromatin binding|fat cell differentiation|positive regulation of transcription by RNA polymerase II|mRNA transport|trophoblast giant cell differentiation|labyrinthine layer development|SUMO-specific endopeptidase activity|SUMO-specific isopeptidase activity|regulation of G1/S transition of mitotic cell cycle "hsa03013,hsa04310" RNA transport|Wnt signaling pathway SENP3 1259.943554 1321.325631 1198.561477 0.907090159 -0.140682142 0.56115098 1 27.47047933 24.50122911 26168 SUMO specific peptidase 3 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0008234,GO:0016926,GO:0016929,GO:0071339" protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|rRNA processing|cysteine-type peptidase activity|protein desumoylation|SUMO-specific protease activity|MLL1 complex SENP5 468.3277133 485.8732832 450.7821434 0.927777178 -0.108149737 0.702262564 1 7.798545602 7.11423947 205564 SUMO specific peptidase 5 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005813,GO:0005829,GO:0007049,GO:0016925,GO:0016926,GO:0016929,GO:0019783,GO:0051301" protein binding|nucleus|nucleoplasm|nucleolus|centrosome|cytosol|cell cycle|protein sumoylation|protein desumoylation|SUMO-specific protease activity|ubiquitin-like protein-specific protease activity|cell division SENP6 1127.453716 1148.616926 1106.290505 0.963150098 -0.054167449 0.827055069 1 10.41447066 9.862848282 26054 SUMO specific peptidase 6 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016925,GO:0016926,GO:0070139,GO:0070646,GO:0090169,GO:0090234" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein sumoylation|protein desumoylation|SUMO-specific endopeptidase activity|protein modification by small protein removal|regulation of spindle assembly|regulation of kinetochore assembly SENP7 436.9467201 444.2567279 429.6367123 0.967091066 -0.048276348 0.872175137 1 3.579822597 3.404082326 57337 SUMO specific peptidase 7 "GO:0005515,GO:0005634,GO:0005737,GO:0016926,GO:0070139" protein binding|nucleus|cytoplasm|protein desumoylation|SUMO-specific endopeptidase activity SENP8 36.14714399 40.57614142 31.71814655 0.781694499 -0.355323209 0.622061862 1 0.437469514 0.336245149 123228 "SUMO peptidase family member, NEDD8 specific" "GO:0005515,GO:0005829,GO:0016579,GO:0019784,GO:0043687" protein binding|cytosol|protein deubiquitination|NEDD8-specific protease activity|post-translational protein modification SEPHS1 978.1140804 949.8978749 1006.330286 1.059408924 0.083259567 0.738479633 1 15.14619174 15.77750244 22929 selenophosphate synthetase 1 "GO:0004756,GO:0005515,GO:0005524,GO:0005525,GO:0005737,GO:0005886,GO:0006464,GO:0016260,GO:0016310,GO:0031965,GO:0042802,GO:0046872" "selenide, water dikinase activity|protein binding|ATP binding|GTP binding|cytoplasm|plasma membrane|cellular protein modification process|selenocysteine biosynthetic process|phosphorylation|nuclear membrane|identical protein binding|metal ion binding" hsa00450 Selenocompound metabolism SEPHS2 1336.652363 1379.588808 1293.715917 0.93775472 -0.092717475 0.701566019 1 32.81021351 30.2530729 22928 selenophosphate synthetase 2 "GO:0001887,GO:0004756,GO:0005524,GO:0005575,GO:0005737,GO:0005829,GO:0016259,GO:0016260,GO:0016310,GO:0046872" "selenium compound metabolic process|selenide, water dikinase activity|ATP binding|cellular_component|cytoplasm|cytosol|selenocysteine metabolic process|selenocysteine biosynthetic process|phosphorylation|metal ion binding" hsa00450 Selenocompound metabolism SEPSECS 349.1204514 346.4578229 351.7830799 1.015370578 0.022006361 0.952043524 1 3.003056236 2.998190464 51091 Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase "GO:0000049,GO:0001514,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0016259,GO:0016785,GO:0097056" "tRNA binding|selenocysteine incorporation|protein binding|nucleus|cytoplasm|cytosol|selenocysteine metabolic process|transferase activity, transferring selenium-containing groups|selenocysteinyl-tRNA(Sec) biosynthetic process" "hsa00450,hsa00970" Selenocompound metabolism|Aminoacyl-tRNA biosynthesis SEPTIN1 40.67552102 33.29324424 48.0577978 1.443469956 0.52954108 0.424424027 1 1.170486993 1.661290262 1731 septin 1 "GO:0003924,GO:0005515,GO:0005525,GO:0005815,GO:0005940,GO:0008021,GO:0015630,GO:0017157,GO:0030496,GO:0031105,GO:0032153,GO:0034613,GO:0042802,GO:0060090,GO:0061640" GTPase activity|protein binding|GTP binding|microtubule organizing center|septin ring|synaptic vesicle|microtubule cytoskeleton|regulation of exocytosis|midbody|septin complex|cell division site|cellular protein localization|identical protein binding|molecular adaptor activity|cytoskeleton-dependent cytokinesis hsa05100 Bacterial invasion of epithelial cells SEPTIN10 3896.312857 3312.677802 4479.947911 1.352364515 0.435484067 0.067495272 1 31.91182777 42.4342592 151011 septin 10 "GO:0003924,GO:0005515,GO:0005525,GO:0005940,GO:0015630,GO:0031105,GO:0032153,GO:0034613,GO:0060090,GO:0061640" GTPase activity|protein binding|GTP binding|septin ring|microtubule cytoskeleton|septin complex|cell division site|cellular protein localization|molecular adaptor activity|cytoskeleton-dependent cytokinesis SEPTIN11 4566.166404 4585.103981 4547.228828 0.991739521 -0.011966846 0.961076278 1 35.62879621 34.74321055 55752 septin 11 "GO:0001725,GO:0003924,GO:0005515,GO:0005525,GO:0005940,GO:0015630,GO:0030424,GO:0031105,GO:0032153,GO:0034613,GO:0043197,GO:0050807,GO:0060090,GO:0061640,GO:0098978,GO:0098982,GO:0099629" stress fiber|GTPase activity|protein binding|GTP binding|septin ring|microtubule cytoskeleton|axon|septin complex|cell division site|cellular protein localization|dendritic spine|regulation of synapse organization|molecular adaptor activity|cytoskeleton-dependent cytokinesis|glutamatergic synapse|GABA-ergic synapse|postsynaptic specialization of symmetric synapse "hsa05100,hsa05131" Bacterial invasion of epithelial cells|Shigellosis SEPTIN14 5.885822626 3.121241648 8.650403604 2.771462315 1.470647391 0.36367629 1 0.043401493 0.118272786 346288 septin 14 "GO:0003924,GO:0005515,GO:0005525,GO:0005940,GO:0015630,GO:0031105,GO:0032153,GO:0034613,GO:0060090,GO:0061640" GTPase activity|protein binding|GTP binding|septin ring|microtubule cytoskeleton|septin complex|cell division site|cellular protein localization|molecular adaptor activity|cytoskeleton-dependent cytokinesis SEPTIN2 9780.235366 7670.971557 11889.49918 1.549933941 0.632206728 0.011984865 0.65036916 94.52451012 144.0551545 4735 septin 2 "GO:0000145,GO:0000777,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005819,GO:0005886,GO:0005930,GO:0005938,GO:0005940,GO:0007224,GO:0007283,GO:0008021,GO:0015629,GO:0015630,GO:0017157,GO:0030496,GO:0031105,GO:0031175,GO:0032153,GO:0032154,GO:0032391,GO:0034613,GO:0045171,GO:0045296,GO:0048471,GO:0060090,GO:0060170,GO:0060271,GO:0061640,GO:0070062,GO:0097227,GO:0097730" exocyst|condensed chromosome kinetochore|GTPase activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|spindle|plasma membrane|axoneme|cell cortex|septin ring|smoothened signaling pathway|spermatogenesis|synaptic vesicle|actin cytoskeleton|microtubule cytoskeleton|regulation of exocytosis|midbody|septin complex|neuron projection development|cell division site|cleavage furrow|photoreceptor connecting cilium|cellular protein localization|intercellular bridge|cadherin binding|perinuclear region of cytoplasm|molecular adaptor activity|ciliary membrane|cilium assembly|cytoskeleton-dependent cytokinesis|extracellular exosome|sperm annulus|non-motile cilium "hsa05100,hsa05131" Bacterial invasion of epithelial cells|Shigellosis SEPTIN3 47.28975624 17.687036 76.89247648 4.347391867 2.120150144 0.000974883 0.194410378 0.142200151 0.607855045 55964 septin 3 "GO:0003674,GO:0003924,GO:0005515,GO:0005525,GO:0005940,GO:0015630,GO:0031105,GO:0032153,GO:0034613,GO:0042802,GO:0043005,GO:0060090,GO:0061640,GO:0098793,GO:0099569" molecular_function|GTPase activity|protein binding|GTP binding|septin ring|microtubule cytoskeleton|septin complex|cell division site|cellular protein localization|identical protein binding|neuron projection|molecular adaptor activity|cytoskeleton-dependent cytokinesis|presynapse|presynaptic cytoskeleton "hsa05100,hsa05131" Bacterial invasion of epithelial cells|Shigellosis SEPTIN4 41.91911014 28.09117483 55.74704545 1.98450388 0.988778383 0.124214224 1 0.342590121 0.668494698 5414 septin 4 "GO:0000287,GO:0003924,GO:0005198,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005739,GO:0005741,GO:0005829,GO:0005940,GO:0006915,GO:0007283,GO:0008021,GO:0015630,GO:0017157,GO:0030154,GO:0031105,GO:0031398,GO:0032153,GO:0034613,GO:0042802,GO:0042981,GO:0043065,GO:0060090,GO:0061640,GO:0097227,GO:2001244" magnesium ion binding|GTPase activity|structural molecule activity|protein binding|GTP binding|nucleus|nucleoplasm|mitochondrion|mitochondrial outer membrane|cytosol|septin ring|apoptotic process|spermatogenesis|synaptic vesicle|microtubule cytoskeleton|regulation of exocytosis|cell differentiation|septin complex|positive regulation of protein ubiquitination|cell division site|cellular protein localization|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|molecular adaptor activity|cytoskeleton-dependent cytokinesis|sperm annulus|positive regulation of intrinsic apoptotic signaling pathway "hsa04210,hsa04215" Apoptosis|Apoptosis - multiple species SEPTIN5 495.3545509 400.5593448 590.149757 1.473314166 0.5590651 0.041308882 1 8.8812281 12.86588211 5413 septin 5 "GO:0003924,GO:0005198,GO:0005515,GO:0005525,GO:0005886,GO:0005940,GO:0008021,GO:0015630,GO:0016080,GO:0017157,GO:0030534,GO:0031105,GO:0032153,GO:0034613,GO:0035176,GO:0042802,GO:0060090,GO:0061640,GO:2000300" GTPase activity|structural molecule activity|protein binding|GTP binding|plasma membrane|septin ring|synaptic vesicle|microtubule cytoskeleton|synaptic vesicle targeting|regulation of exocytosis|adult behavior|septin complex|cell division site|cellular protein localization|social behavior|identical protein binding|molecular adaptor activity|cytoskeleton-dependent cytokinesis|regulation of synaptic vesicle exocytosis "hsa05012,hsa05022" Parkinson disease|Pathways of neurodegeneration - multiple diseases SEPTIN6 1449.276186 1358.780531 1539.771842 1.133201284 0.180404141 0.451256467 1 13.15118237 14.65355628 23157 septin 6 "GO:0000281,GO:0000777,GO:0003924,GO:0005515,GO:0005525,GO:0005819,GO:0005940,GO:0007283,GO:0008021,GO:0015630,GO:0016032,GO:0030154,GO:0030496,GO:0031105,GO:0032153,GO:0032154,GO:0032173,GO:0034613,GO:0043679,GO:0060090,GO:0060271,GO:0061640,GO:0097227" mitotic cytokinesis|condensed chromosome kinetochore|GTPase activity|protein binding|GTP binding|spindle|septin ring|spermatogenesis|synaptic vesicle|microtubule cytoskeleton|viral process|cell differentiation|midbody|septin complex|cell division site|cleavage furrow|septin collar|cellular protein localization|axon terminus|molecular adaptor activity|cilium assembly|cytoskeleton-dependent cytokinesis|sperm annulus "hsa05100,hsa05131" Bacterial invasion of epithelial cells|Shigellosis SEPTIN7 4157.120817 3674.741833 4639.4998 1.262537618 0.336326374 0.158495039 1 67.34691544 83.6051855 989 septin 7 "GO:0000777,GO:0001725,GO:0003924,GO:0005198,GO:0005515,GO:0005525,GO:0005634,GO:0005819,GO:0005829,GO:0005930,GO:0005940,GO:0007283,GO:0015630,GO:0016324,GO:0016476,GO:0030154,GO:0030496,GO:0031105,GO:0032153,GO:0032154,GO:0034613,GO:0042802,GO:0045296,GO:0060090,GO:0060271,GO:0061640,GO:0070062,GO:0097227,GO:0097730,GO:1902857" condensed chromosome kinetochore|stress fiber|GTPase activity|structural molecule activity|protein binding|GTP binding|nucleus|spindle|cytosol|axoneme|septin ring|spermatogenesis|microtubule cytoskeleton|apical plasma membrane|regulation of embryonic cell shape|cell differentiation|midbody|septin complex|cell division site|cleavage furrow|cellular protein localization|identical protein binding|cadherin binding|molecular adaptor activity|cilium assembly|cytoskeleton-dependent cytokinesis|extracellular exosome|sperm annulus|non-motile cilium|positive regulation of non-motile cilium assembly hsa05131 Shigellosis SEPTIN8 3066.996854 2812.238725 3321.754984 1.181178168 0.240226596 0.310473985 1 24.79907668 28.80196386 23176 septin 8 "GO:0003924,GO:0005515,GO:0005525,GO:0005940,GO:0015630,GO:0030424,GO:0030672,GO:0031105,GO:0032153,GO:0034613,GO:0035542,GO:0060090,GO:0061640,GO:0098793" GTPase activity|protein binding|GTP binding|septin ring|microtubule cytoskeleton|axon|synaptic vesicle membrane|septin complex|cell division site|cellular protein localization|regulation of SNARE complex assembly|molecular adaptor activity|cytoskeleton-dependent cytokinesis|presynapse "hsa05100,hsa05131" Bacterial invasion of epithelial cells|Shigellosis SEPTIN9 7210.838282 6743.962787 7677.713776 1.138457316 0.187080202 0.444979133 1 58.76128965 65.77778573 10801 septin 9 "GO:0001725,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005874,GO:0005930,GO:0005940,GO:0015629,GO:0015630,GO:0031105,GO:0032153,GO:0034613,GO:0045296,GO:0048471,GO:0060090,GO:0061640,GO:0097730,GO:1902857" stress fiber|GTPase activity|protein binding|GTP binding|cytoplasm|microtubule|axoneme|septin ring|actin cytoskeleton|microtubule cytoskeleton|septin complex|cell division site|cellular protein localization|cadherin binding|perinuclear region of cytoplasm|molecular adaptor activity|cytoskeleton-dependent cytokinesis|non-motile cilium|positive regulation of non-motile cilium assembly "hsa05100,hsa05131" Bacterial invasion of epithelial cells|Shigellosis SERAC1 200.3154997 212.2444321 188.3865674 0.887592506 -0.172030608 0.64419313 1 2.612337465 2.279891002 84947 serine active site containing 1 "GO:0003674,GO:0005739,GO:0005783,GO:0008654,GO:0016021,GO:0030198,GO:0031012,GO:0032367,GO:0036148,GO:0044233" molecular_function|mitochondrion|endoplasmic reticulum|phospholipid biosynthetic process|integral component of membrane|extracellular matrix organization|extracellular matrix|intracellular cholesterol transport|phosphatidylglycerol acyl-chain remodeling|mitochondria-associated endoplasmic reticulum membrane SERBP1 6651.593971 6773.094376 6530.093565 0.96412263 -0.052711435 0.829166889 1 53.74183741 50.94668918 26135 SERPINE1 mRNA binding protein 1 "GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030578,GO:0032183,GO:0042981,GO:0043488,GO:0045296,GO:0048471,GO:0070062" RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|membrane|PML body organization|SUMO binding|regulation of apoptotic process|regulation of mRNA stability|cadherin binding|perinuclear region of cytoplasm|extracellular exosome SERF1A 5.885822626 3.121241648 8.650403604 2.771462315 1.470647391 0.36367629 1 0.072771922 0.198309721 8293 small EDRK-rich factor 1A "GO:0003674,GO:0005515,GO:0005634,GO:0005829,GO:0007399,GO:0031648,GO:0032991,GO:1990000" molecular_function|protein binding|nucleus|cytosol|nervous system development|protein destabilization|protein-containing complex|amyloid fibril formation SERF1B 27.38288391 24.96993318 29.79583464 1.193268497 0.2549187 0.774245821 1 0.582175378 0.683066817 728492 small EDRK-rich factor 1B "GO:0003674,GO:0005515,GO:0005634,GO:0005829,GO:0007399,GO:0031648,GO:0032991,GO:1990000" molecular_function|protein binding|nucleus|cytosol|nervous system development|protein destabilization|protein-containing complex|amyloid fibril formation SERF2 3188.237712 2576.064773 3800.41065 1.475277598 0.560986447 0.018122709 0.773499658 38.47742579 55.81500082 10169 small EDRK-rich factor 2 "GO:0003674,GO:0005634,GO:0005829,GO:0031648" molecular_function|nucleus|cytosol|protein destabilization SERGEF 267.8090383 280.9117483 254.7063283 0.90671298 -0.141282158 0.673586782 1 10.33200807 9.211402258 26297 secretion regulating guanine nucleotide exchange factor "GO:0005085,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0050709,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|signal transduction|negative regulation of protein secretion|regulation of catalytic activity SERHL2 41.7159349 35.37407201 48.0577978 1.358559958 0.442078239 0.505628678 1 1.2387462 1.654749749 253190 serine hydrolase like 2 "GO:0003674,GO:0005575,GO:0005777,GO:0008150,GO:0016787,GO:0048471" molecular_function|cellular_component|peroxisome|biological_process|hydrolase activity|perinuclear region of cytoplasm SERINC1 3194.956357 2500.11456 3889.798154 1.555847966 0.637701091 0.007279331 0.515776454 42.6964861 65.31763768 57515 serine incorporator 1 "GO:0005515,GO:0005789,GO:0005886,GO:0006658,GO:0006665,GO:0008654,GO:0016020,GO:0016021,GO:0019899,GO:0030674,GO:0044091,GO:1904219,GO:1904222" protein binding|endoplasmic reticulum membrane|plasma membrane|phosphatidylserine metabolic process|sphingolipid metabolic process|phospholipid biosynthetic process|membrane|integral component of membrane|enzyme binding|protein-macromolecule adaptor activity|membrane biogenesis|positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity|positive regulation of serine C-palmitoyltransferase activity SERINC2 1475.345669 1462.821919 1487.86942 1.017122727 0.024493767 0.921254488 1 30.66304684 30.66619152 347735 serine incorporator 2 "GO:0006658,GO:0006665,GO:0016020,GO:0016021,GO:0070062,GO:1904219,GO:1904222" phosphatidylserine metabolic process|sphingolipid metabolic process|membrane|integral component of membrane|extracellular exosome|positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity|positive regulation of serine C-palmitoyltransferase activity SERINC3 5023.908768 4704.751577 5343.065959 1.135674407 0.18354928 0.444700045 1 55.41468654 61.87994208 10955 serine incorporator 3 "GO:0000139,GO:0005515,GO:0005886,GO:0006564,GO:0006658,GO:0006665,GO:0009597,GO:0016020,GO:0016021,GO:0016032,GO:0045087,GO:0048471,GO:0051607,GO:1902237" Golgi membrane|protein binding|plasma membrane|L-serine biosynthetic process|phosphatidylserine metabolic process|sphingolipid metabolic process|detection of virus|membrane|integral component of membrane|viral process|innate immune response|perinuclear region of cytoplasm|defense response to virus|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway SERINC4 3.081612685 5.202069413 0.961155956 0.184764154 -2.436243205 0.338470402 1 0.103979357 0.018890177 619189 serine incorporator 4 "GO:0008654,GO:0016020,GO:0016021" phospholipid biosynthetic process|membrane|integral component of membrane SERINC5 471.0922943 482.7520415 459.432547 0.951694674 -0.071429297 0.803282811 1 3.608345826 3.376579438 256987 serine incorporator 5 "GO:0005794,GO:0005813,GO:0005829,GO:0005886,GO:0006564,GO:0006658,GO:0006665,GO:0008654,GO:0009597,GO:0016020,GO:0016021,GO:0016032,GO:0042552,GO:0043209,GO:0043231,GO:0045087,GO:0048471,GO:0051607,GO:0070062,GO:1904219,GO:1904222" Golgi apparatus|centrosome|cytosol|plasma membrane|L-serine biosynthetic process|phosphatidylserine metabolic process|sphingolipid metabolic process|phospholipid biosynthetic process|detection of virus|membrane|integral component of membrane|viral process|myelination|myelin sheath|intracellular membrane-bounded organelle|innate immune response|perinuclear region of cytoplasm|defense response to virus|extracellular exosome|positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity|positive regulation of serine C-palmitoyltransferase activity SERP1 1847.92255 1440.973227 2254.871873 1.564825654 0.646001927 0.006538927 0.483289646 25.44741653 39.15442355 27230 stress associated endoplasmic reticulum protein 1 "GO:0005515,GO:0005783,GO:0005789,GO:0005829,GO:0005840,GO:0005881,GO:0006464,GO:0006486,GO:0007009,GO:0015031,GO:0016021,GO:0030968,GO:0036498" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|ribosome|cytoplasmic microtubule|cellular protein modification process|protein glycosylation|plasma membrane organization|protein transport|integral component of membrane|endoplasmic reticulum unfolded protein response|IRE1-mediated unfolded protein response SERPINA1 965.5536575 1112.202441 818.9048745 0.736291204 -0.441651627 0.073249842 1 16.27534963 11.78287087 5265 serpin family A member 1 "GO:0000139,GO:0002020,GO:0002576,GO:0004867,GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0005788,GO:0005794,GO:0006888,GO:0006953,GO:0007596,GO:0010951,GO:0030134,GO:0031093,GO:0033116,GO:0042802,GO:0043231,GO:0043312,GO:0043687,GO:0044267,GO:0048208,GO:0062023,GO:0070062,GO:1904813" Golgi membrane|protease binding|platelet degranulation|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|Golgi apparatus|endoplasmic reticulum to Golgi vesicle-mediated transport|acute-phase response|blood coagulation|negative regulation of endopeptidase activity|COPII-coated ER to Golgi transport vesicle|platelet alpha granule lumen|endoplasmic reticulum-Golgi intermediate compartment membrane|identical protein binding|intracellular membrane-bounded organelle|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|COPII vesicle coating|collagen-containing extracellular matrix|extracellular exosome|ficolin-1-rich granule lumen hsa04610 Complement and coagulation cascades SERPINA3 2.601034707 5.202069413 0 0 #NAME? 0.147074026 1 0.153979414 0 12 serpin family A member 3 "GO:0002576,GO:0003677,GO:0004867,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0006953,GO:0006954,GO:0010951,GO:0019216,GO:0030277,GO:0031093,GO:0034774,GO:0035578,GO:0043312,GO:0062023,GO:0070062,GO:0072562" platelet degranulation|DNA binding|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|extracellular space|nucleus|acute-phase response|inflammatory response|negative regulation of endopeptidase activity|regulation of lipid metabolic process|maintenance of gastrointestinal epithelium|platelet alpha granule lumen|secretory granule lumen|azurophil granule lumen|neutrophil degranulation|collagen-containing extracellular matrix|extracellular exosome|blood microparticle SERPINA5 5.682647391 10.40413883 0.961155956 0.092382077 -3.436243205 0.058049477 1 0.243744411 0.022140813 5104 serpin family A member 5 "GO:0001972,GO:0002020,GO:0002080,GO:0004867,GO:0005515,GO:0005539,GO:0005576,GO:0005615,GO:0006869,GO:0007283,GO:0007342,GO:0007596,GO:0008201,GO:0009897,GO:0010951,GO:0016020,GO:0031091,GO:0031094,GO:0031210,GO:0032190,GO:0032991,GO:0036024,GO:0036025,GO:0036026,GO:0036027,GO:0036028,GO:0036029,GO:0036030,GO:0051346,GO:0061107,GO:0062023,GO:0070062,GO:0097181,GO:0097182,GO:0097183" retinoic acid binding|protease binding|acrosomal membrane|serine-type endopeptidase inhibitor activity|protein binding|glycosaminoglycan binding|extracellular region|extracellular space|lipid transport|spermatogenesis|fusion of sperm to egg plasma membrane involved in single fertilization|blood coagulation|heparin binding|external side of plasma membrane|negative regulation of endopeptidase activity|membrane|platelet alpha granule|platelet dense tubular network|phosphatidylcholine binding|acrosin binding|protein-containing complex|protein C inhibitor-TMPRSS7 complex|protein C inhibitor-TMPRSS11E complex|protein C inhibitor-PLAT complex|protein C inhibitor-PLAU complex|protein C inhibitor-thrombin complex|protein C inhibitor-KLK3 complex|protein C inhibitor-plasma kallikrein complex|negative regulation of hydrolase activity|seminal vesicle development|collagen-containing extracellular matrix|extracellular exosome|protein C inhibitor-coagulation factor V complex|protein C inhibitor-coagulation factor Xa complex|protein C inhibitor-coagulation factor XI complex hsa04610 Complement and coagulation cascades SERPINA6 21.85875237 18.72744989 24.99005486 1.334407781 0.416199607 0.646716568 1 0.67667541 0.887851105 866 serpin family A member 6 "GO:0004867,GO:0005496,GO:0005615,GO:0008211,GO:0010951,GO:0070062" serine-type endopeptidase inhibitor activity|steroid binding|extracellular space|glucocorticoid metabolic process|negative regulation of endopeptidase activity|extracellular exosome SERPINA9 15.21494902 8.323311061 22.10658699 2.655984719 1.409246846 0.147519434 1 0.141735741 0.370148617 327657 serpin family A member 9 "GO:0004867,GO:0005615,GO:0005737,GO:0010951,GO:0016020" serine-type endopeptidase inhibitor activity|extracellular space|cytoplasm|negative regulation of endopeptidase activity|membrane SERPINB1 1526.281905 1475.306886 1577.256924 1.069104292 0.096402596 0.687766627 1 25.18695361 26.4768853 1992 serpin family B member 1 "GO:0004867,GO:0005515,GO:0005576,GO:0005615,GO:0010951,GO:0016020,GO:0030414,GO:0032691,GO:0034774,GO:0036464,GO:0043312,GO:0044342,GO:0062023,GO:0070062" serine-type endopeptidase inhibitor activity|protein binding|extracellular region|extracellular space|negative regulation of endopeptidase activity|membrane|peptidase inhibitor activity|negative regulation of interleukin-1 beta production|secretory granule lumen|cytoplasmic ribonucleoprotein granule|neutrophil degranulation|type B pancreatic cell proliferation|collagen-containing extracellular matrix|extracellular exosome SERPINB10 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.070048331 0.084838978 5273 serpin family B member 10 "GO:0004867,GO:0005615,GO:0005654,GO:0005829,GO:0005886,GO:0010951,GO:0030667,GO:0043312,GO:0101003" serine-type endopeptidase inhibitor activity|extracellular space|nucleoplasm|cytosol|plasma membrane|negative regulation of endopeptidase activity|secretory granule membrane|neutrophil degranulation|ficolin-1-rich granule membrane hsa05146 Amoebiasis SERPINB2 23213.61904 25493.26137 20933.97672 0.821157263 -0.284269551 0.309569934 1 600.6748364 484.9946587 5055 serpin family B member 2 "GO:0004867,GO:0005576,GO:0005615,GO:0005737,GO:0005886,GO:0010951,GO:0035722,GO:0042060,GO:0042730,GO:0043066" serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|cytoplasm|plasma membrane|negative regulation of endopeptidase activity|interleukin-12-mediated signaling pathway|wound healing|fibrinolysis|negative regulation of apoptotic process hsa04610 Complement and coagulation cascades SERPINB5 965.8473803 880.1901447 1051.504616 1.19463348 0.25656806 0.298655486 1 31.2327994 36.68738628 5268 serpin family B member 5 "GO:0002009,GO:0004867,GO:0005515,GO:0005615,GO:0005737,GO:0010951,GO:0030198,GO:0050678,GO:0060512" morphogenesis of an epithelium|serine-type endopeptidase inhibitor activity|protein binding|extracellular space|cytoplasm|negative regulation of endopeptidase activity|extracellular matrix organization|regulation of epithelial cell proliferation|prostate gland morphogenesis "hsa04115,hsa05206" p53 signaling pathway|MicroRNAs in cancer SERPINB6 3170.399763 2915.239699 3425.559827 1.175052545 0.232725271 0.32606978 1 30.23338219 34.93133632 5269 serpin family B member 6 "GO:0002020,GO:0004867,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007605,GO:0010951,GO:0030667,GO:0043312,GO:0062023,GO:0070062,GO:0070821,GO:0071470,GO:0097180,GO:0101003" protease binding|serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|nucleus|cytoplasm|cytosol|plasma membrane|sensory perception of sound|negative regulation of endopeptidase activity|secretory granule membrane|neutrophil degranulation|collagen-containing extracellular matrix|extracellular exosome|tertiary granule membrane|cellular response to osmotic stress|serine protease inhibitor complex|ficolin-1-rich granule membrane hsa05146 Amoebiasis SERPINB7 770.125653 498.3582498 1041.893056 2.090650765 1.063952086 3.07E-05 0.013997734 11.42459787 23.48516376 8710 serpin family B member 7 "GO:0004867,GO:0005615,GO:0005737,GO:0010951,GO:0032914,GO:0032967,GO:0072126,GO:0090362" serine-type endopeptidase inhibitor activity|extracellular space|cytoplasm|negative regulation of endopeptidase activity|positive regulation of transforming growth factor beta1 production|positive regulation of collagen biosynthetic process|positive regulation of glomerular mesangial cell proliferation|positive regulation of platelet-derived growth factor production SERPINB8 2957.45906 2926.684252 2988.233867 1.021030494 0.030025954 0.900451029 1 33.61854488 33.75116773 5271 serpin family B member 8 "GO:0004867,GO:0005515,GO:0005615,GO:0005737,GO:0005829,GO:0010951,GO:0062023,GO:0070062,GO:0090136" serine-type endopeptidase inhibitor activity|protein binding|extracellular space|cytoplasm|cytosol|negative regulation of endopeptidase activity|collagen-containing extracellular matrix|extracellular exosome|epithelial cell-cell adhesion SERPINE1 48404.23854 43375.89518 53432.58191 1.231849664 0.300826199 0.35287837 1 695.58047 842.5123345 5054 serpin family E member 1 "GO:0001525,GO:0002020,GO:0002576,GO:0004867,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0007623,GO:0010469,GO:0010757,GO:0010951,GO:0014912,GO:0030194,GO:0030195,GO:0030198,GO:0030336,GO:0031093,GO:0032757,GO:0033629,GO:0035491,GO:0042730,GO:0045766,GO:0045944,GO:0048260,GO:0050729,GO:0050829,GO:0051918,GO:0061044,GO:0061045,GO:0062023,GO:0070062,GO:0071222,GO:0090026,GO:0090399,GO:0097187,GO:1901331,GO:1902042,GO:2000098,GO:2000352" angiogenesis|protease binding|platelet degranulation|serine-type endopeptidase inhibitor activity|signaling receptor binding|protein binding|extracellular region|extracellular space|plasma membrane|circadian rhythm|regulation of signaling receptor activity|negative regulation of plasminogen activation|negative regulation of endopeptidase activity|negative regulation of smooth muscle cell migration|positive regulation of blood coagulation|negative regulation of blood coagulation|extracellular matrix organization|negative regulation of cell migration|platelet alpha granule lumen|positive regulation of interleukin-8 production|negative regulation of cell adhesion mediated by integrin|positive regulation of leukotriene production involved in inflammatory response|fibrinolysis|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|positive regulation of receptor-mediated endocytosis|positive regulation of inflammatory response|defense response to Gram-negative bacterium|negative regulation of fibrinolysis|negative regulation of vascular wound healing|negative regulation of wound healing|collagen-containing extracellular matrix|extracellular exosome|cellular response to lipopolysaccharide|positive regulation of monocyte chemotaxis|replicative senescence|dentinogenesis|positive regulation of odontoblast differentiation|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of endothelial cell apoptotic process "hsa04066,hsa04115,hsa04218,hsa04371,hsa04390,hsa04610,hsa04933,hsa05142" HIF-1 signaling pathway|p53 signaling pathway|Cellular senescence|Apelin signaling pathway|Hippo signaling pathway|Complement and coagulation cascades|AGE-RAGE signaling pathway in diabetic complications|Chagas disease SERPINE2 653.9069988 992.554844 315.2591536 0.317623913 -1.654608561 4.91E-10 1.12E-06 20.57918717 6.427063456 5270 serpin family E member 2 "GO:0004867,GO:0005102,GO:0005515,GO:0005539,GO:0005576,GO:0005615,GO:0005829,GO:0007596,GO:0008201,GO:0008285,GO:0010757,GO:0010766,GO:0010951,GO:0010955,GO:0014067,GO:0021683,GO:0030195,GO:0030308,GO:0030334,GO:0031091,GO:0031232,GO:0031594,GO:0032940,GO:0033363,GO:0042177,GO:0042628,GO:0045861,GO:0045879,GO:0048505,GO:0048711,GO:0050974,GO:0051966,GO:0060291,GO:0060384,GO:0061108,GO:0062023,GO:0090331,GO:1903561" "serine-type endopeptidase inhibitor activity|signaling receptor binding|protein binding|glycosaminoglycan binding|extracellular region|extracellular space|cytosol|blood coagulation|heparin binding|negative regulation of cell population proliferation|negative regulation of plasminogen activation|negative regulation of sodium ion transport|negative regulation of endopeptidase activity|negative regulation of protein processing|negative regulation of phosphatidylinositol 3-kinase signaling|cerebellar granular layer morphogenesis|negative regulation of blood coagulation|negative regulation of cell growth|regulation of cell migration|platelet alpha granule|extrinsic component of external side of plasma membrane|neuromuscular junction|secretion by cell|secretory granule organization|negative regulation of protein catabolic process|mating plug formation|negative regulation of proteolysis|negative regulation of smoothened signaling pathway|regulation of timing of cell differentiation|positive regulation of astrocyte differentiation|detection of mechanical stimulus involved in sensory perception|regulation of synaptic transmission, glutamatergic|long-term synaptic potentiation|innervation|seminal vesicle epithelium development|collagen-containing extracellular matrix|negative regulation of platelet aggregation|extracellular vesicle" SERPINF2 6.004709516 6.242483296 5.766935736 0.923820772 -0.11431511 1 1 0.132412504 0.120278471 5345 serpin family F member 2 "GO:0002020,GO:0002034,GO:0002576,GO:0004866,GO:0004867,GO:0005515,GO:0005576,GO:0005577,GO:0005615,GO:0006953,GO:0009986,GO:0010033,GO:0010757,GO:0010951,GO:0030199,GO:0031093,GO:0032967,GO:0042730,GO:0042803,GO:0045597,GO:0045944,GO:0046330,GO:0048514,GO:0048661,GO:0051496,GO:0051918,GO:0062023,GO:0070062,GO:0070374,GO:0071636,GO:0072562,GO:2000049" protease binding|maintenance of blood vessel diameter homeostasis by renin-angiotensin|platelet degranulation|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|fibrinogen complex|extracellular space|acute-phase response|cell surface|response to organic substance|negative regulation of plasminogen activation|negative regulation of endopeptidase activity|collagen fibril organization|platelet alpha granule lumen|positive regulation of collagen biosynthetic process|fibrinolysis|protein homodimerization activity|positive regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|blood vessel morphogenesis|positive regulation of smooth muscle cell proliferation|positive regulation of stress fiber assembly|negative regulation of fibrinolysis|collagen-containing extracellular matrix|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|positive regulation of transforming growth factor beta production|blood microparticle|positive regulation of cell-cell adhesion mediated by cadherin hsa04610 Complement and coagulation cascades SERPING1 9.690817487 2.080827765 17.30080721 8.314386946 3.055609892 0.021734746 0.822216713 0.059448583 0.486007442 710 serpin family G member 1 "GO:0001869,GO:0002576,GO:0004867,GO:0005515,GO:0005576,GO:0005615,GO:0006958,GO:0007597,GO:0008015,GO:0010951,GO:0030449,GO:0031093,GO:0042730,GO:0045087,GO:0062023,GO:0070062,GO:0072562" "negative regulation of complement activation, lectin pathway|platelet degranulation|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|extracellular space|complement activation, classical pathway|blood coagulation, intrinsic pathway|blood circulation|negative regulation of endopeptidase activity|regulation of complement activation|platelet alpha granule lumen|fibrinolysis|innate immune response|collagen-containing extracellular matrix|extracellular exosome|blood microparticle" "hsa04610,hsa05133" Complement and coagulation cascades|Pertussis SERPINH1 1159.036041 1485.711024 832.3610579 0.56024425 -0.835872159 0.000607967 0.14091439 30.86401976 17.0020416 871 serpin family H member 1 "GO:0003433,GO:0003723,GO:0004867,GO:0005515,GO:0005518,GO:0005615,GO:0005783,GO:0005788,GO:0005793,GO:0006986,GO:0010951,GO:0030199,GO:0032964,GO:0045121,GO:0051082,GO:0051604,GO:0062023" chondrocyte development involved in endochondral bone morphogenesis|RNA binding|serine-type endopeptidase inhibitor activity|protein binding|collagen binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|response to unfolded protein|negative regulation of endopeptidase activity|collagen fibril organization|collagen biosynthetic process|membrane raft|unfolded protein binding|protein maturation|collagen-containing extracellular matrix SERPINI1 73.42402062 60.34400519 86.50403604 1.433514991 0.519556991 0.32403348 1 2.012780406 2.837068445 5274 serpin family I member 1 "GO:0004867,GO:0005615,GO:0007417,GO:0007422,GO:0010951,GO:0010976,GO:0030155,GO:0034774,GO:0043025,GO:0043204,GO:0060205,GO:0070062" serine-type endopeptidase inhibitor activity|extracellular space|central nervous system development|peripheral nervous system development|negative regulation of endopeptidase activity|positive regulation of neuron projection development|regulation of cell adhesion|secretory granule lumen|neuronal cell body|perikaryon|cytoplasmic vesicle lumen|extracellular exosome SERTAD1 147.1946411 155.0216685 139.3676136 0.899020214 -0.15357454 0.719061258 1 3.969875974 3.509276388 29950 SERTA domain containing 1 "GO:0000079,GO:0005515,GO:0005634,GO:0005737,GO:0008284,GO:0045944,GO:0048096,GO:0140110" regulation of cyclin-dependent protein serine/threonine kinase activity|protein binding|nucleus|cytoplasm|positive regulation of cell population proliferation|positive regulation of transcription by RNA polymerase II|chromatin-mediated maintenance of transcription|transcription regulator activity SERTAD2 2022.849248 2046.494107 1999.204388 0.976892326 -0.033728539 0.888650193 1 16.29627413 15.65331043 9792 SERTA domain containing 2 "GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0030308,GO:0048096,GO:0140110" transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|negative regulation of cell growth|chromatin-mediated maintenance of transcription|transcription regulator activity SERTAD3 251.251735 224.7293987 277.7740713 1.236037977 0.30572307 0.363258151 1 6.382860549 7.757438644 29946 SERTA domain containing 3 "GO:0005515,GO:0005634,GO:0006355,GO:0030308,GO:0045893" "protein binding|nucleus|regulation of transcription, DNA-templated|negative regulation of cell growth|positive regulation of transcription, DNA-templated" SERTAD4 258.0735615 290.2754733 225.8716497 0.778128607 -0.361919475 0.275783807 1 2.834669443 2.168827357 56256 SERTA domain containing 4 "GO:0005515,GO:0005634" protein binding|nucleus SESN1 114.2580575 97.79890497 130.71721 1.336591755 0.41855888 0.352759803 1 0.856051798 1.125045275 27244 sestrin 1 "GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016239,GO:0016684,GO:0031932,GO:0034198,GO:0042149,GO:0055114,GO:0061700,GO:0070728,GO:0071233,GO:0072593,GO:0098869,GO:1901031,GO:1904262,GO:1990253" "fibrillar center|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|positive regulation of macroautophagy|oxidoreductase activity, acting on peroxide as acceptor|TORC2 complex|cellular response to amino acid starvation|cellular response to glucose starvation|oxidation-reduction process|GATOR2 complex|leucine binding|cellular response to leucine|reactive oxygen species metabolic process|cellular oxidant detoxification|regulation of response to reactive oxygen species|negative regulation of TORC1 signaling|cellular response to leucine starvation" "hsa04115,hsa04211" p53 signaling pathway|Longevity regulating pathway SESN2 608.3181007 729.3301317 487.3060697 0.668155679 -0.581743807 0.026537442 0.870334587 11.24292567 7.386321082 83667 sestrin 2 "GO:0001932,GO:0005092,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006111,GO:0006635,GO:0009749,GO:0016239,GO:0016684,GO:0030308,GO:0030330,GO:0031588,GO:0031932,GO:0032042,GO:0032542,GO:0032868,GO:0034198,GO:0034599,GO:0036091,GO:0042149,GO:0042593,GO:0043491,GO:0046323,GO:0061700,GO:0070328,GO:0070728,GO:0071230,GO:0071233,GO:0072593,GO:0098869,GO:1900182,GO:1901031,GO:1902010,GO:1904262,GO:1904504,GO:1990253,GO:1990316,GO:2000479" "regulation of protein phosphorylation|GDP-dissociation inhibitor activity|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|regulation of gluconeogenesis|fatty acid beta-oxidation|response to glucose|positive regulation of macroautophagy|oxidoreductase activity, acting on peroxide as acceptor|negative regulation of cell growth|DNA damage response, signal transduction by p53 class mediator|nucleotide-activated protein kinase complex|TORC2 complex|mitochondrial DNA metabolic process|sulfiredoxin activity|response to insulin|cellular response to amino acid starvation|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress|cellular response to glucose starvation|glucose homeostasis|protein kinase B signaling|glucose import|GATOR2 complex|triglyceride homeostasis|leucine binding|cellular response to amino acid stimulus|cellular response to leucine|reactive oxygen species metabolic process|cellular oxidant detoxification|positive regulation of protein localization to nucleus|regulation of response to reactive oxygen species|negative regulation of translation in response to endoplasmic reticulum stress|negative regulation of TORC1 signaling|positive regulation of lipophagy|cellular response to leucine starvation|Atg1/ULK1 kinase complex|regulation of cAMP-dependent protein kinase activity" "hsa04115,hsa04150,hsa04211" p53 signaling pathway|mTOR signaling pathway|Longevity regulating pathway SESN3 249.4533404 215.3656737 283.541007 1.316556172 0.396769077 0.23762899 1 1.153172487 1.492811061 143686 sestrin 3 "GO:0005515,GO:0005634,GO:0005737,GO:0016239,GO:0016684,GO:0031932,GO:0032868,GO:0034198,GO:0038203,GO:0042149,GO:0042593,GO:0046626,GO:0051896,GO:0055114,GO:0061700,GO:0070728,GO:0071233,GO:1901031,GO:1904262,GO:1990253" "protein binding|nucleus|cytoplasm|positive regulation of macroautophagy|oxidoreductase activity, acting on peroxide as acceptor|TORC2 complex|response to insulin|cellular response to amino acid starvation|TORC2 signaling|cellular response to glucose starvation|glucose homeostasis|regulation of insulin receptor signaling pathway|regulation of protein kinase B signaling|oxidation-reduction process|GATOR2 complex|leucine binding|cellular response to leucine|regulation of response to reactive oxygen species|negative regulation of TORC1 signaling|cellular response to leucine starvation" "hsa04115,hsa04211" p53 signaling pathway|Longevity regulating pathway SESTD1 961.1705482 858.3414532 1063.999643 1.239599508 0.309874088 0.209315756 1 4.277134061 5.213212605 91404 SEC14 and spectrin domain containing 1 "GO:0001786,GO:0005515,GO:0005545,GO:0005546,GO:0010314,GO:0031210,GO:0032266,GO:0034704,GO:0043325,GO:0045111,GO:0070273,GO:0070300,GO:0080025,GO:1904878" "phosphatidylserine binding|protein binding|1-phosphatidylinositol binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding|phosphatidylcholine binding|phosphatidylinositol-3-phosphate binding|calcium channel complex|phosphatidylinositol-3,4-bisphosphate binding|intermediate filament cytoskeleton|phosphatidylinositol-4-phosphate binding|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel" SET 7988.440062 8069.450074 7907.43005 0.979921801 -0.02926147 0.906036053 1 116.2039178 111.9652796 6418 SET nuclear proto-oncogene "GO:0003677,GO:0003682,GO:0004864,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005811,GO:0005829,GO:0006260,GO:0006334,GO:0006337,GO:0016032,GO:0019888,GO:0032515,GO:0032991,GO:0035067,GO:0042393,GO:0043488,GO:0043524,GO:0045892,GO:0048471" "DNA binding|chromatin binding|protein phosphatase inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|lipid droplet|cytosol|DNA replication|nucleosome assembly|nucleosome disassembly|viral process|protein phosphatase regulator activity|negative regulation of phosphoprotein phosphatase activity|protein-containing complex|negative regulation of histone acetylation|histone binding|regulation of mRNA stability|negative regulation of neuron apoptotic process|negative regulation of transcription, DNA-templated|perinuclear region of cytoplasm" SETBP1 62.54433423 27.05076095 98.03790751 3.624219951 1.857670514 0.001169499 0.212360525 0.045276757 0.161347053 26040 SET binding protein 1 "GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0016604" DNA binding|protein binding|nucleoplasm|cytosol|nuclear body SETD1A 705.1023583 759.5021343 650.7025822 0.856748853 -0.22305574 0.384567552 1 5.487103425 4.622403532 9739 "SET domain containing 1A, histone lysine methyltransferase" "GO:0000785,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0007420,GO:0008013,GO:0008134,GO:0016607,GO:0035097,GO:0042800,GO:0044648,GO:0045652,GO:0048188,GO:0080182,GO:0097692,GO:1902036,GO:1902275" chromatin|RNA binding|protein binding|nucleus|nucleoplasm|brain development|beta-catenin binding|transcription factor binding|nuclear speck|histone methyltransferase complex|histone methyltransferase activity (H3-K4 specific)|histone H3-K4 dimethylation|regulation of megakaryocyte differentiation|Set1C/COMPASS complex|histone H3-K4 trimethylation|histone H3-K4 monomethylation|regulation of hematopoietic stem cell differentiation|regulation of chromatin organization hsa00310 Lysine degradation SETD1B 534.8349438 616.9654324 452.7044553 0.733759837 -0.446620155 0.096883678 1 3.78376364 2.729914937 23067 "SET domain containing 1B, histone lysine methyltransferase" "GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0016607,GO:0035097,GO:0042800,GO:0044648,GO:0048188,GO:0051568,GO:0080182,GO:0097692" RNA binding|protein binding|nucleoplasm|chromosome|nuclear speck|histone methyltransferase complex|histone methyltransferase activity (H3-K4 specific)|histone H3-K4 dimethylation|Set1C/COMPASS complex|histone H3-K4 methylation|histone H3-K4 trimethylation|histone H3-K4 monomethylation hsa00310 Lysine degradation SETD2 1875.832016 2047.534521 1704.12951 0.832283653 -0.264852794 0.263579555 1 12.56735528 10.28457704 29072 "SET domain containing 2, histone lysine methyltransferase" "GO:0001525,GO:0001763,GO:0001843,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006298,GO:0006355,GO:0006368,GO:0010569,GO:0010793,GO:0016032,GO:0016279,GO:0018023,GO:0018024,GO:0018026,GO:0030900,GO:0032465,GO:0032727,GO:0034340,GO:0034728,GO:0035441,GO:0035987,GO:0043014,GO:0046872,GO:0046975,GO:0048332,GO:0048701,GO:0048863,GO:0048864,GO:0051607,GO:0060039,GO:0060669,GO:0060977,GO:0097198,GO:0097676,GO:1902850,GO:1905634" "angiogenesis|morphogenesis of a branching structure|neural tube closure|protein binding|nucleus|nucleoplasm|chromosome|mismatch repair|regulation of transcription, DNA-templated|transcription elongation from RNA polymerase II promoter|regulation of double-strand break repair via homologous recombination|regulation of mRNA export from nucleus|viral process|protein-lysine N-methyltransferase activity|peptidyl-lysine trimethylation|histone-lysine N-methyltransferase activity|peptidyl-lysine monomethylation|forebrain development|regulation of cytokinesis|positive regulation of interferon-alpha production|response to type I interferon|nucleosome organization|cell migration involved in vasculogenesis|endodermal cell differentiation|alpha-tubulin binding|metal ion binding|histone methyltransferase activity (H3-K36 specific)|mesoderm morphogenesis|embryonic cranial skeleton morphogenesis|stem cell differentiation|stem cell development|defense response to virus|pericardium development|embryonic placenta morphogenesis|coronary vasculature morphogenesis|histone H3-K36 trimethylation|histone H3-K36 dimethylation|microtubule cytoskeleton organization involved in mitosis|regulation of protein localization to chromatin" hsa00310 Lysine degradation SETD3 1466.53172 1471.14523 1461.918209 0.993728001 -0.009077077 0.972861734 1 15.41573082 15.06269993 84193 "SET domain containing 3, actin histidine methyltransferase" "GO:0001102,GO:0003713,GO:0003779,GO:0005515,GO:0005654,GO:0005737,GO:0010452,GO:0016279,GO:0018021,GO:0018023,GO:0018026,GO:0018027,GO:0018064,GO:0030047,GO:0042800,GO:0045893,GO:0045944,GO:0046975,GO:0051149,GO:0051568,GO:0070472" "RNA polymerase II activating transcription factor binding|transcription coactivator activity|actin binding|protein binding|nucleoplasm|cytoplasm|histone H3-K36 methylation|protein-lysine N-methyltransferase activity|peptidyl-histidine methylation|peptidyl-lysine trimethylation|peptidyl-lysine monomethylation|peptidyl-lysine dimethylation|protein-histidine N-methyltransferase activity|actin modification|histone methyltransferase activity (H3-K4 specific)|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|histone methyltransferase activity (H3-K36 specific)|positive regulation of muscle cell differentiation|histone H3-K4 methylation|regulation of uterine smooth muscle contraction" SETD4 300.2801352 300.6796121 299.8806583 0.99734284 -0.003838574 1 1 4.052201584 3.973806307 54093 SET domain containing 4 "GO:0005634,GO:0005829,GO:0016279,GO:0018023,GO:0018026" nucleus|cytosol|protein-lysine N-methyltransferase activity|peptidyl-lysine trimethylation|peptidyl-lysine monomethylation SETD5 3711.544544 3874.501299 3548.58779 0.915882462 -0.12676563 0.594192762 1 12.2562393 11.03743486 55209 SET domain containing 5 "GO:0000791,GO:0005634,GO:0005654,GO:0016569,GO:0016593,GO:0032784,GO:0035065,GO:0046974,GO:0046975,GO:0050890,GO:0051567,GO:0051963,GO:0097198,GO:1902275" "euchromatin|nucleus|nucleoplasm|covalent chromatin modification|Cdc73/Paf1 complex|regulation of DNA-templated transcription, elongation|regulation of histone acetylation|histone methyltransferase activity (H3-K9 specific)|histone methyltransferase activity (H3-K36 specific)|cognition|histone H3-K9 methylation|regulation of synapse assembly|histone H3-K36 trimethylation|regulation of chromatin organization" SETD6 220.6532602 228.8910542 212.4154663 0.928019957 -0.107772264 0.768843974 1 1.940507526 1.770695265 79918 "SET domain containing 6, protein lysine methyltransferase" "GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0016279,GO:0018026,GO:0019827,GO:0032088,GO:0034968,GO:0048863,GO:0050727,GO:0051059" protein binding|nucleus|nucleoplasm|cytosol|protein-lysine N-methyltransferase activity|peptidyl-lysine monomethylation|stem cell population maintenance|negative regulation of NF-kappaB transcription factor activity|histone lysine methylation|stem cell differentiation|regulation of inflammatory response|NF-kappaB binding SETD7 1562.32844 1765.582359 1359.074522 0.769759912 -0.377519555 0.112980848 1 8.589415268 6.501148233 80854 "SET domain containing 7, histone lysine methyltransferase" "GO:0002039,GO:0003682,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0006325,GO:0006974,GO:0016279,GO:0018024,GO:0018026,GO:0018027,GO:0034968,GO:0045471,GO:0045893,GO:0051570,GO:0070828" "p53 binding|chromatin binding|protein binding|nucleoplasm|chromosome|nucleolus|chromatin organization|cellular response to DNA damage stimulus|protein-lysine N-methyltransferase activity|histone-lysine N-methyltransferase activity|peptidyl-lysine monomethylation|peptidyl-lysine dimethylation|histone lysine methylation|response to ethanol|positive regulation of transcription, DNA-templated|regulation of histone H3-K9 methylation|heterochromatin organization" "hsa00310,hsa04068" Lysine degradation|FoxO signaling pathway SETD9 97.51708619 99.87973273 95.15443964 0.952690171 -0.069920991 0.904265231 1 0.86800159 0.813098919 133383 SET domain containing 9 "GO:0005654,GO:0016278,GO:0032259,GO:1901796" nucleoplasm|lysine N-methyltransferase activity|methylation|regulation of signal transduction by p53 class mediator SETDB1 669.1432983 749.0979955 589.188601 0.78653074 -0.346424943 0.179322146 1 8.427062234 6.517230493 9869 SET domain bifurcated histone lysine methyltransferase 1 "GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0007265,GO:0008270,GO:0010629,GO:0018024,GO:0033273,GO:0043231,GO:0045471,GO:0045869,GO:0046974,GO:0051567,GO:0070828,GO:0090309,GO:1990841" DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|Ras protein signal transduction|zinc ion binding|negative regulation of gene expression|histone-lysine N-methyltransferase activity|response to vitamin|intracellular membrane-bounded organelle|response to ethanol|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|histone methyltransferase activity (H3-K9 specific)|histone H3-K9 methylation|heterochromatin organization|positive regulation of DNA methylation-dependent heterochromatin assembly|promoter-specific chromatin binding "hsa00310,hsa04550" Lysine degradation|Signaling pathways regulating pluripotency of stem cells chromosome_remodelling_factor SETDB2 75.61870485 80.11186896 71.12554074 0.887827755 -0.171648285 0.75973384 1 0.685273795 0.598224259 83852 SET domain bifurcated histone lysine methyltransferase 2 "GO:0000278,GO:0001947,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0007059,GO:0008270,GO:0010629,GO:0045892,GO:0046974,GO:0051301,GO:0051567,GO:0070828,GO:0070986,GO:0090309" "mitotic cell cycle|heart looping|DNA binding|protein binding|nucleus|nucleoplasm|chromosome|cytosol|chromosome segregation|zinc ion binding|negative regulation of gene expression|negative regulation of transcription, DNA-templated|histone methyltransferase activity (H3-K9 specific)|cell division|histone H3-K9 methylation|heterochromatin organization|left/right axis specification|positive regulation of DNA methylation-dependent heterochromatin assembly" hsa00310 Lysine degradation SETMAR 104.4433227 105.0818021 103.8048432 0.987847954 -0.017639091 0.993165958 1 1.035454699 1.005755431 6419 SET domain and mariner transposase fusion gene "GO:0000014,GO:0000729,GO:0000737,GO:0000793,GO:0003677,GO:0003690,GO:0003697,GO:0004519,GO:0005515,GO:0005634,GO:0005730,GO:0006303,GO:0008270,GO:0008283,GO:0010452,GO:0015074,GO:0031297,GO:0035861,GO:0042800,GO:0042803,GO:0044547,GO:0044774,GO:0046975,GO:0051568,GO:0071157,GO:0090305,GO:0097676,GO:2000373,GO:2001034,GO:2001251" "single-stranded DNA endodeoxyribonuclease activity|DNA double-strand break processing|DNA catabolic process, endonucleolytic|condensed chromosome|DNA binding|double-stranded DNA binding|single-stranded DNA binding|endonuclease activity|protein binding|nucleus|nucleolus|double-strand break repair via nonhomologous end joining|zinc ion binding|cell population proliferation|histone H3-K36 methylation|DNA integration|replication fork processing|site of double-strand break|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|DNA topoisomerase binding|mitotic DNA integrity checkpoint|histone methyltransferase activity (H3-K36 specific)|histone H3-K4 methylation|negative regulation of cell cycle arrest|nucleic acid phosphodiester bond hydrolysis|histone H3-K36 dimethylation|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity|positive regulation of double-strand break repair via nonhomologous end joining|negative regulation of chromosome organization" hsa00310 Lysine degradation SETSIP 8.927806347 7.282897178 10.57271552 1.451718356 0.537761587 0.724794316 1 0.374806979 0.535009157 646817 SET like protein "GO:0003682,GO:0005634,GO:0005654,GO:0005737,GO:0005811,GO:0006334,GO:0042393,GO:0045446,GO:0045944" chromatin binding|nucleus|nucleoplasm|cytoplasm|lipid droplet|nucleosome assembly|histone binding|endothelial cell differentiation|positive regulation of transcription by RNA polymerase II SETX 3325.191261 3597.751206 3052.631316 0.848483161 -0.237042066 0.31751102 1 15.09001646 12.58937355 23064 senataxin "GO:0000165,GO:0000228,GO:0000781,GO:0001147,GO:0003677,GO:0003678,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006302,GO:0006310,GO:0006353,GO:0006369,GO:0006376,GO:0006396,GO:0006974,GO:0007283,GO:0007399,GO:0007623,GO:0008543,GO:0010976,GO:0016604,GO:0030154,GO:0030424,GO:0030426,GO:0032508,GO:0033120,GO:0034599,GO:0042802,GO:0043066,GO:0043491,GO:0044344,GO:0045171,GO:0045944,GO:0060566,GO:0070301,GO:0071300,GO:2000144,GO:2000806" "MAPK cascade|nuclear chromosome|chromosome, telomeric region|transcription termination site sequence-specific DNA binding|DNA binding|DNA helicase activity|RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|double-strand break repair|DNA recombination|DNA-templated transcription, termination|termination of RNA polymerase II transcription|mRNA splice site selection|RNA processing|cellular response to DNA damage stimulus|spermatogenesis|nervous system development|circadian rhythm|fibroblast growth factor receptor signaling pathway|positive regulation of neuron projection development|nuclear body|cell differentiation|axon|growth cone|DNA duplex unwinding|positive regulation of RNA splicing|cellular response to oxidative stress|identical protein binding|negative regulation of apoptotic process|protein kinase B signaling|cellular response to fibroblast growth factor stimulus|intercellular bridge|positive regulation of transcription by RNA polymerase II|positive regulation of DNA-templated transcription, termination|cellular response to hydrogen peroxide|cellular response to retinoic acid|positive regulation of DNA-templated transcription, initiation|positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled" hsa05014 Amyotrophic lateral sclerosis SEZ6L2 1436.528294 1389.992947 1483.06364 1.066957673 0.093502944 0.697770204 1 19.30298436 20.25083002 26470 seizure related 6 homolog like 2 "GO:0005789,GO:0005886,GO:0016021" endoplasmic reticulum membrane|plasma membrane|integral component of membrane SF1 2737.631748 2933.967149 2541.296348 0.866163873 -0.207288096 0.380948625 1 27.81180006 23.68647 7536 splicing factor 1 "GO:0000245,GO:0000389,GO:0000398,GO:0003714,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005840,GO:0008270,GO:0042802,GO:0045131,GO:0045892,GO:0048024" "spliceosomal complex assembly|mRNA 3'-splice site recognition|mRNA splicing, via spliceosome|transcription corepressor activity|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|ribosome|zinc ion binding|identical protein binding|pre-mRNA branch point binding|negative regulation of transcription, DNA-templated|regulation of mRNA splicing, via spliceosome" SF3A1 2481.84219 2640.570434 2323.113946 0.879777307 -0.184789706 0.434665671 1 27.68612788 23.95003513 10291 splicing factor 3a subunit 1 "GO:0000389,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005684,GO:0005686,GO:0006397,GO:0016607,GO:0071004,GO:0071005,GO:0071013,GO:1903241" "mRNA 3'-splice site recognition|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U2-type spliceosomal complex|U2 snRNP|mRNA processing|nuclear speck|U2-type prespliceosome|U2-type precatalytic spliceosome|catalytic step 2 spliceosome|U2-type prespliceosome assembly" hsa03040 Spliceosome SF3A2 1067.877138 1111.162027 1024.592249 0.92209077 -0.117019319 0.634257589 1 36.62796488 33.20914104 8175 splicing factor 3a subunit 2 "GO:0000245,GO:0000389,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005686,GO:0006397,GO:0008270,GO:0010976,GO:0016607,GO:0071004,GO:0071005,GO:0071013,GO:1903241" "spliceosomal complex assembly|mRNA 3'-splice site recognition|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U2 snRNP|mRNA processing|zinc ion binding|positive regulation of neuron projection development|nuclear speck|U2-type prespliceosome|U2-type precatalytic spliceosome|catalytic step 2 spliceosome|U2-type prespliceosome assembly" hsa03040 Spliceosome SF3A3 1928.057728 1841.532572 2014.582884 1.093970812 0.129574247 0.585163541 1 35.42869819 38.10939974 10946 splicing factor 3a subunit 3 "GO:0000375,GO:0000389,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005686,GO:0006397,GO:0008270,GO:0016607,GO:0071005,GO:0071013,GO:1903241" "RNA splicing, via transesterification reactions|mRNA 3'-splice site recognition|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U2 snRNP|mRNA processing|zinc ion binding|nuclear speck|U2-type precatalytic spliceosome|catalytic step 2 spliceosome|U2-type prespliceosome assembly" hsa03040 Spliceosome SF3B1 8489.968513 8354.523478 8625.413549 1.032424359 0.046036086 0.853014013 1 54.64038763 55.46808764 23451 splicing factor 3b subunit 1 "GO:0000245,GO:0000375,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005686,GO:0005689,GO:0008380,GO:0016607,GO:0034693,GO:0045815,GO:0071004,GO:0071005,GO:0071013,GO:1990935" "spliceosomal complex assembly|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U2 snRNP|U12-type spliceosomal complex|RNA splicing|nuclear speck|U11/U12 snRNP|positive regulation of gene expression, epigenetic|U2-type prespliceosome|U2-type precatalytic spliceosome|catalytic step 2 spliceosome|splicing factor binding" hsa03040 Spliceosome SF3B2 6536.660877 6064.572522 7008.749231 1.155687265 0.20875105 0.391089058 1 98.82598146 112.3007463 10992 splicing factor 3b subunit 2 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005684,GO:0005686,GO:0005689,GO:0006397,GO:0008380,GO:0016032,GO:0016607,GO:0071005,GO:0071011,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U2-type spliceosomal complex|U2 snRNP|U12-type spliceosomal complex|mRNA processing|RNA splicing|viral process|nuclear speck|U2-type precatalytic spliceosome|precatalytic spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SF3B3 6132.934517 6265.372401 6000.496633 0.957723859 -0.062318352 0.797628295 1 34.49973275 32.48831715 23450 splicing factor 3b subunit 3 "GO:0000375,GO:0000398,GO:0003676,GO:0005515,GO:0005634,GO:0005654,GO:0005689,GO:0005730,GO:0008380,GO:0042177,GO:0044877,GO:0071005,GO:0071013" "RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|nucleic acid binding|protein binding|nucleus|nucleoplasm|U12-type spliceosomal complex|nucleolus|RNA splicing|negative regulation of protein catabolic process|protein-containing complex binding|U2-type precatalytic spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SF3B4 1562.275563 1499.236405 1625.314722 1.084095021 0.116491214 0.626262281 1 51.82091415 55.23871895 10262 splicing factor 3b subunit 4 "GO:0000375,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005689,GO:0005730,GO:0006397,GO:0008380,GO:0048026,GO:0071005,GO:1990935" "RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U12-type spliceosomal complex|nucleolus|mRNA processing|RNA splicing|positive regulation of mRNA splicing, via spliceosome|U2-type precatalytic spliceosome|splicing factor binding" hsa03040 Spliceosome SF3B5 1083.573279 1018.565191 1148.581367 1.127646397 0.173314743 0.478997379 1 78.78109015 87.35064199 83443 splicing factor 3b subunit 5 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005686,GO:0005689,GO:0071005,GO:0071011,GO:1990935" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U2 snRNP|U12-type spliceosomal complex|U2-type precatalytic spliceosome|precatalytic spliceosome|splicing factor binding" hsa03040 Spliceosome SF3B6 1552.467088 1292.194042 1812.740133 1.40283895 0.488349393 0.040563002 1 105.9324441 146.1194358 51639 splicing factor 3b subunit 6 "GO:0000398,GO:0001825,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005684,GO:0005686,GO:0005689,GO:0071011,GO:0071013" "mRNA splicing, via spliceosome|blastocyst formation|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|U2-type spliceosomal complex|U2 snRNP|U12-type spliceosomal complex|precatalytic spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SFI1 712.3707786 710.6026818 714.1388753 1.00497633 0.007161522 0.983873074 1 8.031249279 7.936154567 9814 SFI1 centrin binding protein "GO:0000086,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0010389,GO:0010923,GO:0019902,GO:0097711" G2/M transition of mitotic cell cycle|protein binding|centrosome|centriole|cytosol|regulation of G2/M transition of mitotic cell cycle|negative regulation of phosphatase activity|phosphatase binding|ciliary basal body-plasma membrane docking SFMBT1 380.4913837 413.0443114 347.9384561 0.842375616 -0.24746442 0.400837703 1 2.33461298 1.933712306 51460 Scm like with four mbt domains 1 "GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0007283,GO:0030154,GO:0042393,GO:0045892,GO:0048635" "chromatin binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|chromatin organization|spermatogenesis|cell differentiation|histone binding|negative regulation of transcription, DNA-templated|negative regulation of muscle organ development" other SFMBT2 42.75131837 49.93986637 35.56277037 0.712111845 -0.489824245 0.451672414 1 0.315744448 0.221082878 57713 Scm like with four mbt domains 2 "GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0010629,GO:0016235,GO:0016604,GO:0016607,GO:0042393,GO:0043231,GO:0045892" "chromatin binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytosol|negative regulation of gene expression|aggresome|nuclear body|nuclear speck|histone binding|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated" SFN 1318.748903 1086.192093 1551.305713 1.428205676 0.514203757 0.032605395 0.920517339 44.31810068 62.23620076 2810 stratifin "GO:0000079,GO:0001836,GO:0003334,GO:0005515,GO:0005615,GO:0005634,GO:0005739,GO:0005829,GO:0006469,GO:0006977,GO:0007165,GO:0008426,GO:0008630,GO:0010482,GO:0010839,GO:0019901,GO:0030307,GO:0031424,GO:0042802,GO:0043154,GO:0045296,GO:0045606,GO:0046827,GO:0051219,GO:0061024,GO:0061436,GO:0070062,GO:0071901,GO:1900740" "regulation of cyclin-dependent protein serine/threonine kinase activity|release of cytochrome c from mitochondria|keratinocyte development|protein binding|extracellular space|nucleus|mitochondrion|cytosol|negative regulation of protein kinase activity|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|signal transduction|protein kinase C inhibitor activity|intrinsic apoptotic signaling pathway in response to DNA damage|regulation of epidermal cell division|negative regulation of keratinocyte proliferation|protein kinase binding|positive regulation of cell growth|keratinization|identical protein binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|cadherin binding|positive regulation of epidermal cell differentiation|positive regulation of protein export from nucleus|phosphoprotein binding|membrane organization|establishment of skin barrier|extracellular exosome|negative regulation of protein serine/threonine kinase activity|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" "hsa04110,hsa04115,hsa04960" Cell cycle|p53 signaling pathway|Aldosterone-regulated sodium reabsorption SFPQ 3493.848365 3761.096186 3226.600544 0.857888335 -0.22113822 0.351557736 1 22.5101257 18.9880279 6421 splicing factor proline and glutamine rich "GO:0000122,GO:0000380,GO:0000398,GO:0000724,GO:0000785,GO:0000976,GO:0002218,GO:0003676,GO:0003677,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006397,GO:0008380,GO:0016363,GO:0016607,GO:0032839,GO:0042382,GO:0042752,GO:0042754,GO:0042803,GO:0042826,GO:0045087,GO:0045876,GO:0045892,GO:0045944,GO:0048511,GO:0070932,GO:0090575,GO:0098963,GO:1902177" "negative regulation of transcription by RNA polymerase II|alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|double-strand break repair via homologous recombination|chromatin|transcription regulatory region sequence-specific DNA binding|activation of innate immune response|nucleic acid binding|DNA binding|chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|mRNA processing|RNA splicing|nuclear matrix|nuclear speck|dendrite cytoplasm|paraspeckles|regulation of circadian rhythm|negative regulation of circadian rhythm|protein homodimerization activity|histone deacetylase binding|innate immune response|positive regulation of sister chromatid cohesion|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|rhythmic process|histone H3 deacetylation|RNA polymerase II transcription regulator complex|dendritic transport of messenger ribonucleoprotein complex|positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway" SFR1 810.9679076 813.6036562 808.332159 0.993520804 -0.009377917 0.97570863 1 18.85390004 18.4182916 119392 SWI5 dependent homologous recombination repair protein 1 "GO:0000724,GO:0005515,GO:0005634,GO:0030374,GO:0032798,GO:0045893,GO:0071391" "double-strand break repair via homologous recombination|protein binding|nucleus|nuclear receptor coactivator activity|Swi5-Sfr1 complex|positive regulation of transcription, DNA-templated|cellular response to estrogen stimulus" SFSWAP 1034.470037 1028.96933 1039.970744 1.010691684 0.015342963 0.954384596 1 12.83942062 12.75954821 6433 splicing factor SWAP "GO:0000380,GO:0000395,GO:0003723,GO:0005515,GO:0005634,GO:0048025" "alternative mRNA splicing, via spliceosome|mRNA 5'-splice site recognition|RNA binding|protein binding|nucleus|negative regulation of mRNA splicing, via spliceosome" SFT2D1 579.1330205 505.641147 652.6248941 1.290687868 0.368140151 0.164564573 1 26.12307714 33.15253479 113402 SFT2 domain containing 1 "GO:0005515,GO:0015031,GO:0016021,GO:0016192" protein binding|protein transport|integral component of membrane|vesicle-mediated transport SFT2D2 1114.944212 1085.15168 1144.736744 1.054909434 0.077119145 0.754353084 1 5.245702058 5.441140931 375035 SFT2 domain containing 2 "GO:0003674,GO:0005515,GO:0008150,GO:0015031,GO:0016021,GO:0016192,GO:0070062" molecular_function|protein binding|biological_process|protein transport|integral component of membrane|vesicle-mediated transport|extracellular exosome SFT2D3 221.143899 203.921121 238.3666771 1.168916079 0.225171356 0.525794438 1 2.905204334 3.3391136 84826 SFT2 domain containing 3 "GO:0015031,GO:0016021,GO:0016192" protein transport|integral component of membrane|vesicle-mediated transport SFXN1 1514.158015 1548.135857 1480.180172 0.956104831 -0.064759285 0.788245406 1 19.61566129 18.44079521 94081 sideroflexin 1 "GO:0005515,GO:0005739,GO:0006730,GO:0015194,GO:0015825,GO:0022857,GO:0022889,GO:0031305,GO:0042942,GO:0042945,GO:0140300,GO:1990542" protein binding|mitochondrion|one-carbon metabolic process|L-serine transmembrane transporter activity|L-serine transport|transmembrane transporter activity|serine transmembrane transporter activity|integral component of mitochondrial inner membrane|D-serine transport|D-serine transmembrane transporter activity|serine import into mitochondrion|mitochondrial transmembrane transport SFXN2 267.432256 321.4878897 213.3766222 0.663715894 -0.591362271 0.070704815 1 5.346593271 3.489237602 118980 sideroflexin 2 "GO:0005515,GO:0005739,GO:0022857,GO:0022889,GO:0031305,GO:0140300,GO:1990542" protein binding|mitochondrion|transmembrane transporter activity|serine transmembrane transporter activity|integral component of mitochondrial inner membrane|serine import into mitochondrion|mitochondrial transmembrane transport SFXN3 4778.67622 4549.729909 5007.622531 1.100641715 0.138344914 0.563932934 1 76.98501052 83.31502346 81855 sideroflexin 3 "GO:0005739,GO:0006730,GO:0022857,GO:0022889,GO:0031305,GO:0140300,GO:1990542" mitochondrion|one-carbon metabolic process|transmembrane transporter activity|serine transmembrane transporter activity|integral component of mitochondrial inner membrane|serine import into mitochondrion|mitochondrial transmembrane transport SFXN4 236.1802105 258.0226429 214.3377782 0.830693678 -0.26761152 0.437197915 1 6.898894903 5.634970058 119559 sideroflexin 4 "GO:0005739,GO:0006865,GO:0015075,GO:0022857,GO:0031305,GO:0034220,GO:1990542" mitochondrion|amino acid transport|ion transmembrane transporter activity|transmembrane transporter activity|integral component of mitochondrial inner membrane|ion transmembrane transport|mitochondrial transmembrane transport SFXN5 185.9824487 201.8402932 170.1246042 0.842867405 -0.246622402 0.515154052 1 2.061597222 1.708575829 94097 sideroflexin 5 "GO:0005515,GO:0005739,GO:0006865,GO:0015137,GO:0015746,GO:0022857,GO:0031305,GO:0034220,GO:1990542" protein binding|mitochondrion|amino acid transport|citrate transmembrane transporter activity|citrate transport|transmembrane transporter activity|integral component of mitochondrial inner membrane|ion transmembrane transport|mitochondrial transmembrane transport SGCA 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.030127497 0.082100009 6442 sarcoglycan alpha "GO:0005509,GO:0005515,GO:0005737,GO:0005856,GO:0005911,GO:0006936,GO:0007517,GO:0014894,GO:0016010,GO:0016012,GO:0016021,GO:0042383,GO:0043403,GO:0045121" calcium ion binding|protein binding|cytoplasm|cytoskeleton|cell-cell junction|muscle contraction|muscle organ development|response to denervation involved in regulation of muscle adaptation|dystrophin-associated glycoprotein complex|sarcoglycan complex|integral component of membrane|sarcolemma|skeletal muscle tissue regeneration|membrane raft "hsa05410,hsa05412,hsa05414,hsa05416" Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Viral myocarditis SGCB 1381.931103 1319.244803 1444.617402 1.095033612 0.130975154 0.586243656 1 16.57383957 17.84521395 6443 sarcoglycan beta "GO:0005515,GO:0005737,GO:0005856,GO:0005887,GO:0007517,GO:0016010,GO:0016012,GO:0042383,GO:0048747,GO:0055013,GO:0097084" protein binding|cytoplasm|cytoskeleton|integral component of plasma membrane|muscle organ development|dystrophin-associated glycoprotein complex|sarcoglycan complex|sarcolemma|muscle fiber development|cardiac muscle cell development|vascular associated smooth muscle cell development "hsa05410,hsa05412,hsa05414,hsa05416" Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Viral myocarditis SGCE 720.3424594 705.4006124 735.2843063 1.042364145 0.059859365 0.819363694 1 8.397486998 8.60676575 8910 sarcoglycan epsilon "GO:0005794,GO:0005856,GO:0005886,GO:0005887,GO:0007160,GO:0007517,GO:0016010,GO:0016012,GO:0032590,GO:0042383" Golgi apparatus|cytoskeleton|plasma membrane|integral component of plasma membrane|cell-matrix adhesion|muscle organ development|dystrophin-associated glycoprotein complex|sarcoglycan complex|dendrite membrane|sarcolemma SGCZ 10.32991132 6.242483296 14.41733934 2.309551929 1.207612985 0.304444422 1 0.045357367 0.103002258 137868 sarcoglycan zeta "GO:0005737,GO:0005856,GO:0016012,GO:0016021,GO:0042383,GO:0046716,GO:0048738,GO:0055001,GO:0060047,GO:0061024" cytoplasm|cytoskeleton|sarcoglycan complex|integral component of membrane|sarcolemma|muscle cell cellular homeostasis|cardiac muscle tissue development|muscle cell development|heart contraction|membrane organization SGF29 143.7859358 166.4662212 121.1056505 0.727508858 -0.458963281 0.266623874 1 5.241295737 3.749282193 112869 SAGA complex associated factor 29 "GO:0000124,GO:0005515,GO:0005671,GO:0016573,GO:0019899,GO:0035064,GO:0043966,GO:0047485,GO:0070461,GO:0071169" SAGA complex|protein binding|Ada2/Gcn5/Ada3 transcription activator complex|histone acetylation|enzyme binding|methylated histone binding|histone H3 acetylation|protein N-terminus binding|SAGA-type complex|establishment of protein localization to chromatin SGIP1 5.643018428 9.363724944 1.922311912 0.205293505 -2.284240111 0.166157707 1 0.042185108 0.00851541 84251 SH3GL interacting endocytic adaptor 1 "GO:0002021,GO:0005515,GO:0005543,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005905,GO:0008017,GO:0017124,GO:0030122,GO:0030136,GO:0048260,GO:0048268,GO:0061024,GO:0072583,GO:0097009,GO:2000253" response to dietary excess|protein binding|phospholipid binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|clathrin-coated pit|microtubule binding|SH3 domain binding|AP-2 adaptor complex|clathrin-coated vesicle|positive regulation of receptor-mediated endocytosis|clathrin coat assembly|membrane organization|clathrin-dependent endocytosis|energy homeostasis|positive regulation of feeding behavior SGK1 345.1569407 343.3365813 346.9773001 1.010603935 0.015217703 0.970489046 1 4.875796252 4.845043859 6446 serum/glucocorticoid regulated kinase 1 "GO:0001558,GO:0004674,GO:0004712,GO:0005246,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005789,GO:0005829,GO:0005886,GO:0006468,GO:0006814,GO:0006915,GO:0006974,GO:0007616,GO:0008217,GO:0015459,GO:0016607,GO:0017080,GO:0017081,GO:0018105,GO:0030334,GO:0032411,GO:0034220,GO:0035556,GO:0042127,GO:0042981,GO:0048812,GO:0050790,GO:0051090,GO:0060453,GO:0070294,GO:0106310,GO:0106311,GO:1904045" regulation of cell growth|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|calcium channel regulator activity|protein binding|ATP binding|nucleus|cytoplasm|mitochondrion|endoplasmic reticulum membrane|cytosol|plasma membrane|protein phosphorylation|sodium ion transport|apoptotic process|cellular response to DNA damage stimulus|long-term memory|regulation of blood pressure|potassium channel regulator activity|nuclear speck|sodium channel regulator activity|chloride channel regulator activity|peptidyl-serine phosphorylation|regulation of cell migration|positive regulation of transporter activity|ion transmembrane transport|intracellular signal transduction|regulation of cell population proliferation|regulation of apoptotic process|neuron projection morphogenesis|regulation of catalytic activity|regulation of DNA-binding transcription factor activity|regulation of gastric acid secretion|renal sodium ion absorption|protein serine kinase activity|protein threonine kinase activity|cellular response to aldosterone "hsa04068,hsa04150,hsa04151,hsa04960" FoxO signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Aldosterone-regulated sodium reabsorption SGK2 11.48921209 11.44455271 11.53387147 1.007804478 0.011215772 1 1 0.234103006 0.231982088 10110 serum/glucocorticoid regulated kinase 2 "GO:0001558,GO:0004674,GO:0005524,GO:0005654,GO:0005829,GO:0006468,GO:0006979,GO:0015459,GO:0017080,GO:0018105,GO:0032411,GO:0034220,GO:0035556,GO:0042127,GO:0106310,GO:0106311" regulation of cell growth|protein serine/threonine kinase activity|ATP binding|nucleoplasm|cytosol|protein phosphorylation|response to oxidative stress|potassium channel regulator activity|sodium channel regulator activity|peptidyl-serine phosphorylation|positive regulation of transporter activity|ion transmembrane transport|intracellular signal transduction|regulation of cell population proliferation|protein serine kinase activity|protein threonine kinase activity "hsa04068,hsa04151" FoxO signaling pathway|PI3K-Akt signaling pathway SGMS1 740.2939911 686.6731625 793.9148197 1.156175693 0.209360647 0.411496237 1 3.410244243 3.876863388 259230 sphingomyelin synthase 1 "GO:0000138,GO:0000139,GO:0002950,GO:0005634,GO:0005783,GO:0005886,GO:0005887,GO:0006686,GO:0006915,GO:0006954,GO:0010628,GO:0016020,GO:0016301,GO:0016310,GO:0030148,GO:0030173,GO:0030176,GO:0033188,GO:0046513,GO:0047493,GO:0071222,GO:0071356,GO:2001242" Golgi trans cisterna|Golgi membrane|ceramide phosphoethanolamine synthase activity|nucleus|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|sphingomyelin biosynthetic process|apoptotic process|inflammatory response|positive regulation of gene expression|membrane|kinase activity|phosphorylation|sphingolipid biosynthetic process|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|sphingomyelin synthase activity|ceramide biosynthetic process|ceramide cholinephosphotransferase activity|cellular response to lipopolysaccharide|cellular response to tumor necrosis factor|regulation of intrinsic apoptotic signaling pathway "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway SGMS2 946.5594801 941.5745638 951.5443964 1.010588469 0.015195623 0.955635538 1 6.493100391 6.452048667 166929 sphingomyelin synthase 2 "GO:0002950,GO:0005515,GO:0005794,GO:0005886,GO:0005887,GO:0006686,GO:0016301,GO:0016310,GO:0030148,GO:0030173,GO:0030176,GO:0030500,GO:0033188,GO:0046513,GO:0047493,GO:1905373" ceramide phosphoethanolamine synthase activity|protein binding|Golgi apparatus|plasma membrane|integral component of plasma membrane|sphingomyelin biosynthetic process|kinase activity|phosphorylation|sphingolipid biosynthetic process|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|regulation of bone mineralization|sphingomyelin synthase activity|ceramide biosynthetic process|ceramide cholinephosphotransferase activity|ceramide phosphoethanolamine biosynthetic process "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway SGO1 615.5173239 653.3799183 577.6547296 0.884102363 -0.177714678 0.499428008 1 6.004767587 5.219993144 151648 shugoshin 1 "GO:0000070,GO:0000775,GO:0000776,GO:0000777,GO:0000779,GO:0000922,GO:0005515,GO:0005654,GO:0005813,GO:0005829,GO:0007059,GO:0008608,GO:0010457,GO:0019900,GO:0045132,GO:0045143,GO:0051177,GO:0051301,GO:0071962" "mitotic sister chromatid segregation|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|condensed chromosome, centromeric region|spindle pole|protein binding|nucleoplasm|centrosome|cytosol|chromosome segregation|attachment of spindle microtubules to kinetochore|centriole-centriole cohesion|kinase binding|meiotic chromosome segregation|homologous chromosome segregation|meiotic sister chromatid cohesion|cell division|mitotic sister chromatid cohesion, centromeric" hsa04114 Oocyte meiosis SGO2 1023.27209 1189.193068 857.3511127 0.720951993 -0.472024898 0.054318875 1 10.25117887 7.266936028 151246 shugoshin 2 "GO:0000070,GO:0000775,GO:0000776,GO:0000777,GO:0005515,GO:0005654,GO:0005829,GO:0016604,GO:0030892,GO:0045143,GO:0051177,GO:0051301,GO:0051754" "mitotic sister chromatid segregation|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|protein binding|nucleoplasm|cytosol|nuclear body|mitotic cohesin complex|homologous chromosome segregation|meiotic sister chromatid cohesion|cell division|meiotic sister chromatid cohesion, centromeric" SGPL1 1148.533751 1310.921492 986.1460108 0.752254057 -0.410708113 0.090888078 1 13.79366535 10.20270671 8879 sphingosine-1-phosphate lyase 1 "GO:0001553,GO:0001570,GO:0001667,GO:0001822,GO:0005515,GO:0005783,GO:0005789,GO:0006631,GO:0006672,GO:0007283,GO:0008117,GO:0008209,GO:0008210,GO:0009791,GO:0010761,GO:0016831,GO:0030097,GO:0030148,GO:0030149,GO:0030170,GO:0030176,GO:0033327,GO:0040014,GO:0048008,GO:0048705,GO:0060021,GO:0060325,GO:0097190" luteinization|vasculogenesis|ameboidal-type cell migration|kidney development|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|fatty acid metabolic process|ceramide metabolic process|spermatogenesis|sphinganine-1-phosphate aldolase activity|androgen metabolic process|estrogen metabolic process|post-embryonic development|fibroblast migration|carboxy-lyase activity|hemopoiesis|sphingolipid biosynthetic process|sphingolipid catabolic process|pyridoxal phosphate binding|integral component of endoplasmic reticulum membrane|Leydig cell differentiation|regulation of multicellular organism growth|platelet-derived growth factor receptor signaling pathway|skeletal system morphogenesis|roof of mouth development|face morphogenesis|apoptotic signaling pathway "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway SGPP1 1159.608395 1059.141333 1260.075458 1.189714177 0.250615014 0.302335165 1 16.36491786 19.14377781 81537 sphingosine-1-phosphate phosphatase 1 "GO:0005789,GO:0005886,GO:0006668,GO:0006670,GO:0016020,GO:0016021,GO:0030148,GO:0035621,GO:0042392,GO:0045616,GO:0045682,GO:0046839,GO:0097191,GO:0097193" endoplasmic reticulum membrane|plasma membrane|sphinganine-1-phosphate metabolic process|sphingosine metabolic process|membrane|integral component of membrane|sphingolipid biosynthetic process|ER to Golgi ceramide transport|sphingosine-1-phosphate phosphatase activity|regulation of keratinocyte differentiation|regulation of epidermis development|phospholipid dephosphorylation|extrinsic apoptotic signaling pathway|intrinsic apoptotic signaling pathway "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway SGPP2 25.33665469 34.33365813 16.33965125 0.47590767 -1.071246388 0.169114348 1 0.346309626 0.162053512 130367 sphingosine-1-phosphate phosphatase 2 "GO:0005783,GO:0005789,GO:0006670,GO:0016020,GO:0016021,GO:0030148,GO:0042392,GO:0046839,GO:0061469" endoplasmic reticulum|endoplasmic reticulum membrane|sphingosine metabolic process|membrane|integral component of membrane|sphingolipid biosynthetic process|sphingosine-1-phosphate phosphatase activity|phospholipid dephosphorylation|regulation of type B pancreatic cell proliferation "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway SGSH 860.466825 914.5238028 806.4098471 0.881781146 -0.181507465 0.468404219 1 12.18029811 10.5606319 6448 N-sulfoglucosamine sulfohydrolase "GO:0005539,GO:0005764,GO:0006027,GO:0008449,GO:0016250,GO:0030200,GO:0043202,GO:0046872,GO:0070062" glycosaminoglycan binding|lysosome|glycosaminoglycan catabolic process|N-acetylglucosamine-6-sulfatase activity|N-sulfoglucosamine sulfohydrolase activity|heparan sulfate proteoglycan catabolic process|lysosomal lumen|metal ion binding|extracellular exosome "hsa00531,hsa04142" Glycosaminoglycan degradation|Lysosome SGSM2 1244.634256 1348.376392 1140.89212 0.846122883 -0.241060893 0.318369199 1 10.21728948 8.500418684 9905 small G protein signaling modulator 2 "GO:0005096,GO:0005737,GO:0006886,GO:0031267,GO:0034499,GO:0042470,GO:0043547,GO:0090630" GTPase activator activity|cytoplasm|intracellular protein transport|small GTPase binding|late endosome to Golgi transport|melanosome|positive regulation of GTPase activity|activation of GTPase activity SGSM3 846.8030503 833.37152 860.2345806 1.032234196 0.04577033 0.859201764 1 14.0834409 14.29414543 27352 small G protein signaling modulator 3 "GO:0005096,GO:0005515,GO:0005829,GO:0005921,GO:0006886,GO:0007050,GO:0031267,GO:0032483,GO:0032486,GO:0043547,GO:0045732,GO:0048227,GO:0090630,GO:1902017" GTPase activator activity|protein binding|cytosol|gap junction|intracellular protein transport|cell cycle arrest|small GTPase binding|regulation of Rab protein signal transduction|Rap protein signal transduction|positive regulation of GTPase activity|positive regulation of protein catabolic process|plasma membrane to endosome transport|activation of GTPase activity|regulation of cilium assembly SGTA 1424.884982 1462.821919 1386.948044 0.948131845 -0.076840404 0.750285939 1 32.39340965 30.19927905 6449 small glutamine rich tetratricopeptide repeat co-chaperone alpha "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006620,GO:0016020,GO:0016032,GO:0030433,GO:0042802,GO:0043621,GO:0060090,GO:0071816,GO:0072380,GO:1903070,GO:1903071,GO:1903646,GO:1904288,GO:2000059" protein binding|nucleus|cytoplasm|cytosol|posttranslational protein targeting to endoplasmic reticulum membrane|membrane|viral process|ubiquitin-dependent ERAD pathway|identical protein binding|protein self-association|molecular adaptor activity|tail-anchored membrane protein insertion into ER membrane|TRC complex|negative regulation of ER-associated ubiquitin-dependent protein catabolic process|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|positive regulation of chaperone-mediated protein folding|BAT3 complex binding|negative regulation of ubiquitin-dependent protein catabolic process SGTB 1035.95643 1017.524777 1054.388084 1.036228412 0.051342046 0.83763702 1 9.657376352 9.83979002 54557 small glutamine rich tetratricopeptide repeat co-chaperone beta "GO:0005515,GO:0006620,GO:0016020,GO:0030433,GO:0060090,GO:0072380,GO:1903646" protein binding|posttranslational protein targeting to endoplasmic reticulum membrane|membrane|ubiquitin-dependent ERAD pathway|molecular adaptor activity|TRC complex|positive regulation of chaperone-mediated protein folding SH2B1 571.2902875 488.9945248 653.5860501 1.336591755 0.41855888 0.114949388 1 7.718645092 10.14404176 25970 SH2B adaptor protein 1 "GO:0005068,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0007169,GO:0007596,GO:0030032,GO:0035556,GO:0045840,GO:0060391,GO:2000278" transmembrane receptor protein tyrosine kinase adaptor activity|protein binding|nucleus|cytosol|plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|blood coagulation|lamellipodium assembly|intracellular signal transduction|positive regulation of mitotic nuclear division|positive regulation of SMAD protein signal transduction|regulation of DNA biosynthetic process hsa04722 Neurotrophin signaling pathway SH2B2 187.320387 161.2641518 213.3766222 1.32314975 0.403976351 0.280212563 1 2.847905821 3.705150054 10603 SH2B adaptor protein 2 "GO:0005068,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007596,GO:0008286,GO:0035556,GO:0035591,GO:0042169,GO:0050851,GO:0050853" transmembrane receptor protein tyrosine kinase adaptor activity|protein binding|cytoplasm|cytosol|plasma membrane|blood coagulation|insulin receptor signaling pathway|intracellular signal transduction|signaling adaptor activity|SH2 domain binding|antigen receptor-mediated signaling pathway|B cell receptor signaling pathway "hsa04722,hsa04910" Neurotrophin signaling pathway|Insulin signaling pathway SH2B3 7687.700085 7617.910449 7757.489721 1.018322514 0.026194551 0.915702543 1 54.13500393 54.2044194 10019 SH2B adaptor protein 3 "GO:0001780,GO:0005068,GO:0005173,GO:0005515,GO:0005829,GO:0005886,GO:0007169,GO:0007596,GO:0008285,GO:0030159,GO:0035162,GO:0035556,GO:0035702,GO:0035855,GO:0036016,GO:0038163,GO:0042532,GO:0043407,GO:0046426,GO:0048821,GO:0051898,GO:0060761,GO:0070100,GO:0090331,GO:1900235,GO:1990782,GO:1990869" neutrophil homeostasis|transmembrane receptor protein tyrosine kinase adaptor activity|stem cell factor receptor binding|protein binding|cytosol|plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|blood coagulation|negative regulation of cell population proliferation|signaling receptor complex adaptor activity|embryonic hemopoiesis|intracellular signal transduction|monocyte homeostasis|megakaryocyte development|cellular response to interleukin-3|thrombopoietin-mediated signaling pathway|negative regulation of tyrosine phosphorylation of STAT protein|negative regulation of MAP kinase activity|negative regulation of receptor signaling pathway via JAK-STAT|erythrocyte development|negative regulation of protein kinase B signaling|negative regulation of response to cytokine stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of platelet aggregation|negative regulation of Kit signaling pathway|protein tyrosine kinase binding|cellular response to chemokine hsa04722 Neurotrophin signaling pathway SH2D1B 7.56533034 9.363724944 5.766935736 0.615880514 -0.699277611 0.654804973 1 0.19744164 0.11956564 117157 SH2 domain containing 1B "GO:0002250,GO:0002366,GO:0002717,GO:0005515,GO:0005829,GO:0030674,GO:0045087,GO:0045089,GO:0050776" adaptive immune response|leukocyte activation involved in immune response|positive regulation of natural killer cell mediated immunity|protein binding|cytosol|protein-macromolecule adaptor activity|innate immune response|positive regulation of innate immune response|regulation of immune response hsa04650 Natural killer cell mediated cytotoxicity SH2D2A 145.5000421 186.234085 104.7659992 0.562550079 -0.829946562 0.043038047 1 5.624771269 3.11126666 9047 SH2 domain containing 2A "GO:0001525,GO:0005515,GO:0005737,GO:0005829,GO:0007165,GO:0008283,GO:0017124,GO:0030154,GO:0048010" angiogenesis|protein binding|cytoplasm|cytosol|signal transduction|cell population proliferation|SH3 domain binding|cell differentiation|vascular endothelial growth factor receptor signaling pathway hsa04370 VEGF signaling pathway SH2D3A 165.4962332 156.0620824 174.930384 1.120902536 0.16466084 0.68420469 1 2.732528382 3.011644544 10045 SH2 domain containing 3A "GO:0001784,GO:0005085,GO:0005515,GO:0007254,GO:0007264,GO:0033138,GO:0050790" phosphotyrosine residue binding|guanyl-nucleotide exchange factor activity|protein binding|JNK cascade|small GTPase mediated signal transduction|positive regulation of peptidyl-serine phosphorylation|regulation of catalytic activity SH2D3C 3.403674809 1.040413883 5.766935736 5.54292463 2.470647391 0.304382079 1 0.013619077 0.074226302 10044 SH2 domain containing 3C "GO:0001784,GO:0005085,GO:0005515,GO:0005737,GO:0007254,GO:0007264,GO:0030424,GO:0032587,GO:0033138,GO:0050790" phosphotyrosine residue binding|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|JNK cascade|small GTPase mediated signal transduction|axon|ruffle membrane|positive regulation of peptidyl-serine phosphorylation|regulation of catalytic activity SH2D4A 309.0544561 291.3158871 326.793025 1.121782366 0.165792809 0.600697845 1 4.625704695 5.1022025 63898 SH2 domain containing 4A "GO:0005515,GO:0005737,GO:0005829,GO:0010923,GO:0019902" protein binding|cytoplasm|cytosol|negative regulation of phosphatase activity|phosphatase binding SH2D4B 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.038541168 0.023339552 387694 SH2 domain containing 4B GO:0005737 cytoplasm SH2D5 329.3771253 345.417409 313.3368417 0.907125216 -0.140626387 0.651812712 1 3.750618977 3.345348482 400745 SH2 domain containing 5 GO:0014069 postsynaptic density SH2D6 10.92937619 9.363724944 12.49502743 1.334407781 0.416199607 0.772652545 1 0.071892503 0.094328592 284948 SH2 domain containing 6 "GO:0005737,GO:0007169,GO:0035556" cytoplasm|transmembrane receptor protein tyrosine kinase signaling pathway|intracellular signal transduction SH3BGRL 3166.695377 2666.580781 3666.809972 1.375098027 0.459534469 0.052651863 1 62.7471408 84.83963252 6451 SH3 domain binding glutamate rich protein like "GO:0005615,GO:0005634,GO:0005737,GO:0017124,GO:0070062" extracellular space|nucleus|cytoplasm|SH3 domain binding|extracellular exosome SH3BGRL2 217.204926 239.295193 195.1146591 0.815372246 -0.294469244 0.406536535 1 2.562862662 2.054719002 83699 SH3 domain binding glutamate rich protein like 2 "GO:0005654,GO:0017124,GO:0031965" nucleoplasm|SH3 domain binding|nuclear membrane SH3BGRL3 2779.346339 2376.305308 3182.38737 1.339216539 0.42138925 0.075021656 1 168.8669066 222.365051 83442 SH3 domain binding glutamate rich protein like 3 "GO:0005515,GO:0005737,GO:0015035,GO:0016604,GO:0055114,GO:0070062" protein binding|cytoplasm|protein disulfide oxidoreductase activity|nuclear body|oxidation-reduction process|extracellular exosome SH3BP1 843.0125323 897.8771807 788.1478839 0.877790305 -0.18805176 0.453453842 1 18.02786114 15.5598771 23616 SH3 domain binding protein 1 "GO:0000145,GO:0001891,GO:0005096,GO:0005515,GO:0005622,GO:0005634,GO:0005829,GO:0005912,GO:0005923,GO:0006911,GO:0007015,GO:0016477,GO:0017124,GO:0030027,GO:0030215,GO:0030834,GO:0031252,GO:0032956,GO:0034329,GO:0035020,GO:0043535,GO:0043547,GO:0045198,GO:0046847,GO:0051058,GO:0071526,GO:0097178" "exocyst|phagocytic cup|GTPase activator activity|protein binding|intracellular anatomical structure|nucleus|cytosol|adherens junction|bicellular tight junction|phagocytosis, engulfment|actin filament organization|cell migration|SH3 domain binding|lamellipodium|semaphorin receptor binding|regulation of actin filament depolymerization|cell leading edge|regulation of actin cytoskeleton organization|cell junction assembly|regulation of Rac protein signal transduction|regulation of blood vessel endothelial cell migration|positive regulation of GTPase activity|establishment of epithelial cell apical/basal polarity|filopodium assembly|negative regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway|ruffle assembly" SH3BP2 1628.28148 1781.188567 1475.374392 0.828308928 -0.271759156 0.253216539 1 9.829258623 8.005422973 6452 SH3 domain binding protein 2 "GO:0001784,GO:0005515,GO:0007165,GO:0017124" phosphotyrosine residue binding|protein binding|signal transduction|SH3 domain binding hsa04650 Natural killer cell mediated cytotoxicity SH3BP4 3755.185978 4200.150844 3310.221112 0.788119578 -0.343513554 0.148579732 1 35.13941543 27.23063866 23677 SH3 domain binding protein 4 "GO:0005092,GO:0005515,GO:0005634,GO:0005737,GO:0005905,GO:0006897,GO:0008285,GO:0010508,GO:0030136,GO:0030308,GO:0031267,GO:0032007,GO:0034260,GO:0042802,GO:0043090,GO:0050790,GO:0061462,GO:0070062,GO:0071230" GDP-dissociation inhibitor activity|protein binding|nucleus|cytoplasm|clathrin-coated pit|endocytosis|negative regulation of cell population proliferation|positive regulation of autophagy|clathrin-coated vesicle|negative regulation of cell growth|small GTPase binding|negative regulation of TOR signaling|negative regulation of GTPase activity|identical protein binding|amino acid import|regulation of catalytic activity|protein localization to lysosome|extracellular exosome|cellular response to amino acid stimulus SH3BP5 831.048387 773.0275148 889.0692593 1.150113343 0.201776045 0.421829769 1 10.67953862 12.07714585 9467 SH3 domain binding protein 5 "GO:0004860,GO:0005085,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0007165,GO:0016604,GO:0017124,GO:0030659,GO:0035556,GO:0061099" protein kinase inhibitor activity|guanyl-nucleotide exchange factor activity|protein binding|nucleoplasm|cytoplasm|mitochondrion|signal transduction|nuclear body|SH3 domain binding|cytoplasmic vesicle membrane|intracellular signal transduction|negative regulation of protein tyrosine kinase activity SH3BP5L 1401.471253 1327.568114 1475.374392 1.111336116 0.152295217 0.526008768 1 15.5270371 16.96700539 80851 SH3 binding domain protein 5 like "GO:0004860,GO:0005085,GO:0005515,GO:0005737,GO:0035556,GO:0061099" protein kinase inhibitor activity|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|intracellular signal transduction|negative regulation of protein tyrosine kinase activity SH3D19 715.2586625 799.0378619 631.4794631 0.790299801 -0.33952805 0.183683725 1 5.206102078 4.045532834 152503 SH3 domain containing 19 "GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0007010,GO:0022604,GO:0051044" protein binding|nucleoplasm|cytosol|plasma membrane|cytoskeleton organization|regulation of cell morphogenesis|positive regulation of membrane protein ectodomain proteolysis SH3D21 203.1297705 185.1936711 221.0658699 1.193700997 0.25544151 0.484864167 1 3.466659367 4.068908328 79729 SH3 domain containing 21 "GO:0005654,GO:0005886" nucleoplasm|plasma membrane SH3GL1 1495.302232 1431.609503 1558.994961 1.08898059 0.12297824 0.607814518 1 29.00621411 31.05863507 6455 "SH3 domain containing GRB2 like 1, endophilin A2" "GO:0002102,GO:0005515,GO:0005737,GO:0005829,GO:0007165,GO:0007417,GO:0008022,GO:0008289,GO:0016191,GO:0017124,GO:0019902,GO:0031697,GO:0031901,GO:0042802,GO:0042995,GO:0044325,GO:0045296,GO:0051020,GO:0098685,GO:0098686,GO:0098793,GO:0098815,GO:0098978,GO:0099092,GO:1900244" "podosome|protein binding|cytoplasm|cytosol|signal transduction|central nervous system development|protein C-terminus binding|lipid binding|synaptic vesicle uncoating|SH3 domain binding|phosphatase binding|beta-1 adrenergic receptor binding|early endosome membrane|identical protein binding|cell projection|ion channel binding|cadherin binding|GTPase binding|Schaffer collateral - CA1 synapse|hippocampal mossy fiber to CA3 synapse|presynapse|modulation of excitatory postsynaptic potential|glutamatergic synapse|postsynaptic density, intracellular component|positive regulation of synaptic vesicle endocytosis" hsa04144 Endocytosis SH3GL3 14.49156685 14.56579436 14.41733934 0.98980797 -0.014779436 1 1 0.110309305 0.107357966 6457 "SH3 domain containing GRB2 like 3, endophilin A3" "GO:0001669,GO:0005515,GO:0006897,GO:0007165,GO:0007417,GO:0008022,GO:0008289,GO:0031901,GO:0042802,GO:0045666,GO:0098793,GO:0098845,GO:0098978,GO:0099092,GO:1900186" "acrosomal vesicle|protein binding|endocytosis|signal transduction|central nervous system development|protein C-terminus binding|lipid binding|early endosome membrane|identical protein binding|positive regulation of neuron differentiation|presynapse|postsynaptic endosome|glutamatergic synapse|postsynaptic density, intracellular component|negative regulation of clathrin-dependent endocytosis" hsa04144 Endocytosis SH3GLB1 2887.730593 2938.128805 2837.332382 0.965693668 -0.050362477 0.83268771 1 22.41637373 21.28511108 51100 "SH3 domain containing GRB2 like, endophilin B1" "GO:0000139,GO:0000421,GO:0005515,GO:0005737,GO:0005741,GO:0005829,GO:0006914,GO:0006915,GO:0008289,GO:0010508,GO:0016241,GO:0030496,GO:0031334,GO:0031410,GO:0031647,GO:0032465,GO:0032801,GO:0032991,GO:0034198,GO:0042149,GO:0042802,GO:0042803,GO:0045296,GO:0048102,GO:0090148,GO:1903527,GO:1903778,GO:1903955,GO:2000786" Golgi membrane|autophagosome membrane|protein binding|cytoplasm|mitochondrial outer membrane|cytosol|autophagy|apoptotic process|lipid binding|positive regulation of autophagy|regulation of macroautophagy|midbody|positive regulation of protein-containing complex assembly|cytoplasmic vesicle|regulation of protein stability|regulation of cytokinesis|receptor catabolic process|protein-containing complex|cellular response to amino acid starvation|cellular response to glucose starvation|identical protein binding|protein homodimerization activity|cadherin binding|autophagic cell death|membrane fission|positive regulation of membrane tubulation|protein localization to vacuolar membrane|positive regulation of protein targeting to mitochondrion|positive regulation of autophagosome assembly "hsa04140,hsa04144" Autophagy - animal|Endocytosis SH3GLB2 1806.309182 1648.01559 1964.602774 1.192102056 0.253507751 0.285107002 1 24.64319505 28.88561578 56904 "SH3 domain containing GRB2 like, endophilin B2" "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0042802,GO:0045296" protein binding|nucleoplasm|cytoplasm|cytosol|identical protein binding|cadherin binding hsa04144 Endocytosis SH3KBP1 4923.758622 4977.340015 4870.177229 0.978469868 -0.031400671 0.896646082 1 48.58816327 46.74650184 30011 SH3 domain containing kinase binding protein 1 "GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005911,GO:0005925,GO:0006897,GO:0006915,GO:0007010,GO:0007015,GO:0007267,GO:0007411,GO:0008360,GO:0016477,GO:0017124,GO:0030139,GO:0030659,GO:0042059,GO:0043005,GO:0045202,GO:0050871,GO:0061024" protein binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|cell-cell junction|focal adhesion|endocytosis|apoptotic process|cytoskeleton organization|actin filament organization|cell-cell signaling|axon guidance|regulation of cell shape|cell migration|SH3 domain binding|endocytic vesicle|cytoplasmic vesicle membrane|negative regulation of epidermal growth factor receptor signaling pathway|neuron projection|synapse|positive regulation of B cell activation|membrane organization hsa04144 Endocytosis SH3PXD2A 785.5218125 852.0989699 718.9446551 0.843733745 -0.245140292 0.331685741 1 3.908126154 3.242240093 9644 SH3 and PX domains 2A "GO:0001701,GO:0002020,GO:0002102,GO:0005515,GO:0005546,GO:0005737,GO:0005829,GO:0006801,GO:0010314,GO:0016176,GO:0030054,GO:0030198,GO:0032266,GO:0042995,GO:0043325,GO:0050790,GO:0070273,GO:0072675" "in utero embryonic development|protease binding|podosome|protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|cytosol|superoxide metabolic process|phosphatidylinositol-5-phosphate binding|superoxide-generating NADPH oxidase activator activity|cell junction|extracellular matrix organization|phosphatidylinositol-3-phosphate binding|cell projection|phosphatidylinositol-3,4-bisphosphate binding|regulation of catalytic activity|phosphatidylinositol-4-phosphate binding|osteoclast fusion" SH3PXD2B 3050.027671 3678.903489 2421.151853 0.658117795 -0.603582263 0.010971374 0.623624625 24.35632275 15.76110031 285590 SH3 and PX domains 2B "GO:0001501,GO:0001654,GO:0002102,GO:0005515,GO:0005737,GO:0006801,GO:0007507,GO:0010314,GO:0016176,GO:0022617,GO:0030054,GO:0030154,GO:0032266,GO:0042169,GO:0042995,GO:0050790,GO:0060348,GO:0060612,GO:0070273,GO:0071800,GO:0072657,GO:0080025" "skeletal system development|eye development|podosome|protein binding|cytoplasm|superoxide metabolic process|heart development|phosphatidylinositol-5-phosphate binding|superoxide-generating NADPH oxidase activator activity|extracellular matrix disassembly|cell junction|cell differentiation|phosphatidylinositol-3-phosphate binding|SH2 domain binding|cell projection|regulation of catalytic activity|bone development|adipose tissue development|phosphatidylinositol-4-phosphate binding|podosome assembly|protein localization to membrane|phosphatidylinositol-3,5-bisphosphate binding" SH3RF1 1239.468014 1149.65734 1329.278687 1.156239029 0.209439677 0.38651113 1 11.98341783 13.6238391 57630 SH3 domain containing ring finger 1 "GO:0001764,GO:0005078,GO:0005515,GO:0005794,GO:0005829,GO:0016032,GO:0030027,GO:0043066,GO:0043154,GO:0043370,GO:0046330,GO:0046872,GO:0048471,GO:0051865,GO:0061630,GO:2000564,GO:2001237" "neuron migration|MAP-kinase scaffold activity|protein binding|Golgi apparatus|cytosol|viral process|lamellipodium|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of JNK cascade|metal ion binding|perinuclear region of cytoplasm|protein autoubiquitination|ubiquitin protein ligase activity|regulation of CD8-positive, alpha-beta T cell proliferation|negative regulation of extrinsic apoptotic signaling pathway" SH3RF2 839.3459316 953.0191165 725.6727468 0.76144616 -0.393186064 0.115952718 1 8.036163481 6.016710876 153769 SH3 domain containing ring finger 2 "GO:0004864,GO:0005515,GO:0005634,GO:0005654,GO:0008157,GO:0010923,GO:0019902,GO:0030335,GO:0031397,GO:0032436,GO:0032515,GO:0043066,GO:0046329,GO:0046330,GO:0046872,GO:0051865,GO:0061630" protein phosphatase inhibitor activity|protein binding|nucleus|nucleoplasm|protein phosphatase 1 binding|negative regulation of phosphatase activity|phosphatase binding|positive regulation of cell migration|negative regulation of protein ubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of phosphoprotein phosphatase activity|negative regulation of apoptotic process|negative regulation of JNK cascade|positive regulation of JNK cascade|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity SH3RF3 7.723846193 13.52538047 1.922311912 0.142126273 -2.814754828 0.050094394 1 0.065865927 0.00920463 344558 SH3 domain containing ring finger 3 "GO:0005515,GO:0006915,GO:0046330,GO:0046872,GO:0051865,GO:0061630" protein binding|apoptotic process|positive regulation of JNK cascade|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity SH3TC1 162.6523943 157.1024963 168.2022923 1.070653212 0.098491263 0.816301616 1 1.333376508 1.40369516 54436 SH3 domain and tetratricopeptide repeats 1 "GO:0005575,GO:0008150" cellular_component|biological_process SH3TC2 507.6904481 497.3178359 518.0630603 1.041714218 0.058959545 0.835278682 1 1.002755738 1.027105195 79628 SH3 domain and tetratricopeptide repeats 2 "GO:0005886,GO:0031410,GO:0032287,GO:0033157,GO:1901184" plasma membrane|cytoplasmic vesicle|peripheral nervous system myelin maintenance|regulation of intracellular protein transport|regulation of ERBB signaling pathway SH3YL1 33.50648032 34.33365813 32.6793025 0.951815341 -0.071246388 0.965552154 1 0.891641962 0.834477012 26751 SH3 and SYLF domain containing 1 "GO:0005515,GO:0006661,GO:0019902,GO:0032587,GO:0035091" protein binding|phosphatidylinositol biosynthetic process|phosphatase binding|ruffle membrane|phosphatidylinositol binding SHANK1 472.0484198 495.2370081 448.8598314 0.906353572 -0.141854134 0.612940425 1 2.74254321 2.444118781 50944 SH3 and multiple ankyrin repeat domains 1 "GO:0005515,GO:0005829,GO:0005886,GO:0007610,GO:0007616,GO:0008022,GO:0008306,GO:0008328,GO:0014069,GO:0016020,GO:0017124,GO:0017146,GO:0030160,GO:0030425,GO:0030534,GO:0031877,GO:0032232,GO:0035176,GO:0035255,GO:0035418,GO:0042802,GO:0043005,GO:0043197,GO:0044877,GO:0045211,GO:0048854,GO:0050885,GO:0050894,GO:0051124,GO:0051968,GO:0060074,GO:0060076,GO:0060291,GO:0060997,GO:0060999,GO:0065003,GO:0071532,GO:0071625,GO:0097107,GO:0097110,GO:2000311,GO:2000463" "protein binding|cytosol|plasma membrane|behavior|long-term memory|protein C-terminus binding|associative learning|ionotropic glutamate receptor complex|postsynaptic density|membrane|SH3 domain binding|NMDA selective glutamate receptor complex|synaptic receptor adaptor activity|dendrite|adult behavior|somatostatin receptor binding|negative regulation of actin filament bundle assembly|social behavior|ionotropic glutamate receptor binding|protein localization to synapse|identical protein binding|neuron projection|dendritic spine|protein-containing complex binding|postsynaptic membrane|brain morphogenesis|neuromuscular process controlling balance|determination of affect|synaptic growth at neuromuscular junction|positive regulation of synaptic transmission, glutamatergic|synapse maturation|excitatory synapse|long-term synaptic potentiation|dendritic spine morphogenesis|positive regulation of dendritic spine development|protein-containing complex assembly|ankyrin repeat binding|vocalization behavior|postsynaptic density assembly|scaffold protein binding|regulation of AMPA receptor activity|positive regulation of excitatory postsynaptic potential" hsa04724 Glutamatergic synapse SHANK2 144.9056076 170.6278768 119.1833385 0.698498632 -0.517670804 0.208139292 1 0.616777037 0.423608763 22941 SH3 and multiple ankyrin repeat domains 2 "GO:0001750,GO:0001917,GO:0005515,GO:0005575,GO:0005829,GO:0005883,GO:0005886,GO:0007416,GO:0007610,GO:0007612,GO:0008284,GO:0008328,GO:0014069,GO:0016324,GO:0017124,GO:0030160,GO:0030426,GO:0030534,GO:0031526,GO:0035176,GO:0035255,GO:0035331,GO:0043005,GO:0043025,GO:0043197,GO:0045211,GO:0048854,GO:0051124,GO:0051968,GO:0060170,GO:0060291,GO:0060292,GO:0060997,GO:0060999,GO:0071625,GO:0097107,GO:2000311,GO:2000463" "photoreceptor outer segment|photoreceptor inner segment|protein binding|cellular_component|cytosol|neurofilament|plasma membrane|synapse assembly|behavior|learning|positive regulation of cell population proliferation|ionotropic glutamate receptor complex|postsynaptic density|apical plasma membrane|SH3 domain binding|synaptic receptor adaptor activity|growth cone|adult behavior|brush border membrane|social behavior|ionotropic glutamate receptor binding|negative regulation of hippo signaling|neuron projection|neuronal cell body|dendritic spine|postsynaptic membrane|brain morphogenesis|synaptic growth at neuromuscular junction|positive regulation of synaptic transmission, glutamatergic|ciliary membrane|long-term synaptic potentiation|long-term synaptic depression|dendritic spine morphogenesis|positive regulation of dendritic spine development|vocalization behavior|postsynaptic density assembly|regulation of AMPA receptor activity|positive regulation of excitatory postsynaptic potential" hsa04724 Glutamatergic synapse SHANK3 104.5225806 107.1626299 101.8825313 0.950728173 -0.072895183 0.895055847 1 0.747395792 0.698679805 85358 SH3 and multiple ankyrin repeat domains 3 "GO:0000165,GO:0003779,GO:0005515,GO:0005829,GO:0007411,GO:0007416,GO:0007610,GO:0007612,GO:0007613,GO:0008022,GO:0008270,GO:0008328,GO:0014069,GO:0017124,GO:0021773,GO:0030160,GO:0030534,GO:0031234,GO:0032232,GO:0035176,GO:0035255,GO:0042297,GO:0043005,GO:0043197,GO:0043621,GO:0044309,GO:0045211,GO:0045794,GO:0048170,GO:0048854,GO:0051124,GO:0051835,GO:0051968,GO:0060170,GO:0060291,GO:0060997,GO:0060999,GO:0061001,GO:0071625,GO:0097107,GO:0097110,GO:0097113,GO:0097114,GO:0097117,GO:1900271,GO:1900273,GO:1900451,GO:1900452,GO:2000311,GO:2000463,GO:2000969" "MAPK cascade|actin binding|protein binding|cytosol|axon guidance|synapse assembly|behavior|learning|memory|protein C-terminus binding|zinc ion binding|ionotropic glutamate receptor complex|postsynaptic density|SH3 domain binding|striatal medium spiny neuron differentiation|synaptic receptor adaptor activity|adult behavior|extrinsic component of cytoplasmic side of plasma membrane|negative regulation of actin filament bundle assembly|social behavior|ionotropic glutamate receptor binding|vocal learning|neuron projection|dendritic spine|protein self-association|neuron spine|postsynaptic membrane|negative regulation of cell volume|positive regulation of long-term neuronal synaptic plasticity|brain morphogenesis|synaptic growth at neuromuscular junction|positive regulation of synapse structural plasticity|positive regulation of synaptic transmission, glutamatergic|ciliary membrane|long-term synaptic potentiation|dendritic spine morphogenesis|positive regulation of dendritic spine development|regulation of dendritic spine morphogenesis|vocalization behavior|postsynaptic density assembly|scaffold protein binding|AMPA glutamate receptor clustering|NMDA glutamate receptor clustering|guanylate kinase-associated protein clustering|regulation of long-term synaptic potentiation|positive regulation of long-term synaptic potentiation|positive regulation of glutamate receptor signaling pathway|regulation of long-term synaptic depression|regulation of AMPA receptor activity|positive regulation of excitatory postsynaptic potential|positive regulation of AMPA receptor activity" hsa04724 Glutamatergic synapse SHARPIN 1103.539288 1063.302988 1143.775588 1.075681721 0.105251267 0.668233894 1 42.09682953 44.52504385 81858 SHANK associated RH domain interactor "GO:0000151,GO:0004842,GO:0005515,GO:0005829,GO:0007005,GO:0007249,GO:0007420,GO:0010803,GO:0014069,GO:0030262,GO:0030425,GO:0031424,GO:0031593,GO:0042802,GO:0043123,GO:0043130,GO:0043161,GO:0044877,GO:0046872,GO:0050728,GO:0071797,GO:0097039,GO:2000348" ubiquitin ligase complex|ubiquitin-protein transferase activity|protein binding|cytosol|mitochondrion organization|I-kappaB kinase/NF-kappaB signaling|brain development|regulation of tumor necrosis factor-mediated signaling pathway|postsynaptic density|apoptotic nuclear changes|dendrite|keratinization|polyubiquitin modification-dependent protein binding|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein-containing complex binding|metal ion binding|negative regulation of inflammatory response|LUBAC complex|protein linear polyubiquitination|regulation of CD40 signaling pathway "hsa04217,hsa04621,hsa05131" Necroptosis|NOD-like receptor signaling pathway|Shigellosis SHB 1204.623595 1155.899824 1253.347367 1.084304488 0.116769943 0.631446435 1 10.22174799 10.89802008 6461 SH2 domain containing adaptor protein B "GO:0001525,GO:0001784,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006915,GO:0007165,GO:0030154,GO:0036464,GO:0048010" angiogenesis|phosphotyrosine residue binding|protein binding|nucleoplasm|cytosol|plasma membrane|apoptotic process|signal transduction|cell differentiation|cytoplasmic ribonucleoprotein granule|vascular endothelial growth factor receptor signaling pathway SHBG 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.089172875 0.054000827 6462 sex hormone binding globulin "GO:0005496,GO:0005497,GO:0005515,GO:0005576,GO:0070062" steroid binding|androgen binding|protein binding|extracellular region|extracellular exosome SHC1 7488.497998 7624.152932 7352.843063 0.964414425 -0.052274866 0.831799355 1 120.2740258 114.0530028 6464 SHC adaptor protein 1 "GO:0000165,GO:0000187,GO:0001525,GO:0001784,GO:0005068,GO:0005154,GO:0005158,GO:0005159,GO:0005168,GO:0005515,GO:0005543,GO:0005759,GO:0005829,GO:0005886,GO:0007169,GO:0007173,GO:0007176,GO:0007265,GO:0007411,GO:0007507,GO:0008284,GO:0008286,GO:0016032,GO:0019221,GO:0019901,GO:0030971,GO:0031532,GO:0035723,GO:0036498,GO:0038095,GO:0038110,GO:0038128,GO:0040008,GO:0042742,GO:0043066,GO:0043410,GO:0045892,GO:0045893,GO:0046579,GO:0046875,GO:0048408,GO:0050900,GO:0070374,GO:0070435,GO:0071363,GO:0098609" "MAPK cascade|activation of MAPK activity|angiogenesis|phosphotyrosine residue binding|transmembrane receptor protein tyrosine kinase adaptor activity|epidermal growth factor receptor binding|insulin receptor binding|insulin-like growth factor receptor binding|neurotrophin TRKA receptor binding|protein binding|phospholipid binding|mitochondrial matrix|cytosol|plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|epidermal growth factor receptor signaling pathway|regulation of epidermal growth factor-activated receptor activity|Ras protein signal transduction|axon guidance|heart development|positive regulation of cell population proliferation|insulin receptor signaling pathway|viral process|cytokine-mediated signaling pathway|protein kinase binding|receptor tyrosine kinase binding|actin cytoskeleton reorganization|interleukin-15-mediated signaling pathway|IRE1-mediated unfolded protein response|Fc-epsilon receptor signaling pathway|interleukin-2-mediated signaling pathway|ERBB2 signaling pathway|regulation of growth|defense response to bacterium|negative regulation of apoptotic process|positive regulation of MAPK cascade|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of Ras protein signal transduction|ephrin receptor binding|epidermal growth factor binding|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|Shc-EGFR complex|cellular response to growth factor stimulus|cell-cell adhesion" "hsa01521,hsa01522,hsa04012,hsa04014,hsa04062,hsa04072,hsa04510,hsa04650,hsa04722,hsa04910,hsa04915,hsa04917,hsa04926,hsa04935,hsa05034,hsa05100,hsa05206,hsa05214,hsa05220,hsa05224,hsa05225,hsa05226" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|Ras signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Focal adhesion|Natural killer cell mediated cytotoxicity|Neurotrophin signaling pathway|Insulin signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Alcoholism|Bacterial invasion of epithelial cells|MicroRNAs in cancer|Glioma|Chronic myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer" SHC3 239.9852054 256.982229 222.9881818 0.867718296 -0.204701346 0.55263647 1 0.651590139 0.555935537 53358 SHC adaptor protein 3 "GO:0000165,GO:0001784,GO:0005515,GO:0005575,GO:0005829,GO:0005886,GO:0007169,GO:0007173,GO:0007265,GO:0007411,GO:0007417,GO:0019901,GO:0030971" MAPK cascade|phosphotyrosine residue binding|protein binding|cellular_component|cytosol|plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|epidermal growth factor receptor signaling pathway|Ras protein signal transduction|axon guidance|central nervous system development|protein kinase binding|receptor tyrosine kinase binding "hsa01521,hsa01522,hsa04012,hsa04014,hsa04062,hsa04072,hsa04510,hsa04650,hsa04722,hsa04910,hsa04915,hsa04917,hsa04926,hsa04935,hsa05034,hsa05100,hsa05214,hsa05220,hsa05224,hsa05225,hsa05226" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|Ras signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Focal adhesion|Natural killer cell mediated cytotoxicity|Neurotrophin signaling pathway|Insulin signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Alcoholism|Bacterial invasion of epithelial cells|Glioma|Chronic myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer" SHC4 24.62333335 15.60620824 33.64045846 2.155581801 1.108077311 0.161928887 1 0.160229829 0.339608894 399694 SHC adaptor protein 4 "GO:0005515,GO:0005886,GO:0006915,GO:0007169,GO:0008284,GO:0010468,GO:0019901,GO:0019904,GO:0030971,GO:0035556,GO:0045211,GO:0048863" protein binding|plasma membrane|apoptotic process|transmembrane receptor protein tyrosine kinase signaling pathway|positive regulation of cell population proliferation|regulation of gene expression|protein kinase binding|protein domain specific binding|receptor tyrosine kinase binding|intracellular signal transduction|postsynaptic membrane|stem cell differentiation "hsa01521,hsa01522,hsa04012,hsa04014,hsa04062,hsa04072,hsa04510,hsa04650,hsa04722,hsa04910,hsa04915,hsa04917,hsa04926,hsa04935,hsa05034,hsa05100,hsa05206,hsa05214,hsa05220,hsa05224,hsa05225,hsa05226" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|Ras signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Focal adhesion|Natural killer cell mediated cytotoxicity|Neurotrophin signaling pathway|Insulin signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Alcoholism|Bacterial invasion of epithelial cells|MicroRNAs in cancer|Glioma|Chronic myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer" SHCBP1 1890.597183 1880.027886 1901.166481 1.011243767 0.01613081 0.948096991 1 16.290572 16.19807367 79801 SHC binding and spindle associated 1 "GO:0005515,GO:0005737,GO:0005819,GO:0008543,GO:0030496,GO:2000177" protein binding|cytoplasm|spindle|fibroblast growth factor receptor signaling pathway|midbody|regulation of neural precursor cell proliferation SHF 50.80225711 46.81862472 54.78588949 1.170172978 0.226721808 0.728380573 1 0.655290835 0.753972207 90525 Src homology 2 domain containing F "GO:0001784,GO:0006915" phosphotyrosine residue binding|apoptotic process SHFL 501.5819429 450.4992112 552.6646747 1.22678278 0.294879821 0.281122521 1 9.369569337 11.30208266 55337 shiftless antiviral inhibitor of ribosomal frameshifting "GO:0000932,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006449,GO:0034340,GO:0034341,GO:0034342,GO:0035456,GO:0043022,GO:0045071,GO:0051607,GO:0075523,GO:1990825,GO:2001125" P-body|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of translational termination|response to type I interferon|response to interferon-gamma|response to type III interferon|response to interferon-beta|ribosome binding|negative regulation of viral genome replication|defense response to virus|viral translational frameshifting|sequence-specific mRNA binding|negative regulation of translational frameshifting SHH 7.084752362 9.363724944 4.80577978 0.513233762 -0.962312016 0.521952192 1 0.094806449 0.047843647 6469 sonic hedgehog signaling molecule "GO:0000122,GO:0001569,GO:0001570,GO:0001656,GO:0001658,GO:0001708,GO:0001755,GO:0001947,GO:0002052,GO:0002076,GO:0002320,GO:0003140,GO:0005113,GO:0005509,GO:0005515,GO:0005539,GO:0005576,GO:0005615,GO:0005788,GO:0005829,GO:0005886,GO:0006897,GO:0007224,GO:0007228,GO:0007267,GO:0007389,GO:0007398,GO:0007405,GO:0007411,GO:0007417,GO:0007418,GO:0007442,GO:0007507,GO:0007596,GO:0008209,GO:0008233,GO:0008270,GO:0008284,GO:0009880,GO:0009949,GO:0009953,GO:0009986,GO:0010468,GO:0014003,GO:0014706,GO:0014858,GO:0014902,GO:0016015,GO:0016539,GO:0016540,GO:0021513,GO:0021522,GO:0021794,GO:0021904,GO:0021930,GO:0021938,GO:0021978,GO:0030010,GO:0030162,GO:0030177,GO:0030324,GO:0030326,GO:0030336,GO:0030539,GO:0030850,GO:0030878,GO:0030900,GO:0030901,GO:0030902,GO:0031016,GO:0031069,GO:0032435,GO:0033077,GO:0033089,GO:0033092,GO:0034244,GO:0034504,GO:0035115,GO:0035116,GO:0042127,GO:0042130,GO:0042307,GO:0042475,GO:0042481,GO:0042733,GO:0043010,GO:0043066,GO:0043237,GO:0043369,GO:0045059,GO:0045060,GO:0045109,GO:0045121,GO:0045445,GO:0045596,GO:0045880,GO:0045893,GO:0045944,GO:0046638,GO:0046639,GO:0048468,GO:0048538,GO:0048557,GO:0048617,GO:0048643,GO:0048645,GO:0048663,GO:0048706,GO:0048709,GO:0048714,GO:0048745,GO:0048754,GO:0048839,GO:0048859,GO:0048864,GO:0051155,GO:0051781,GO:0060020,GO:0060021,GO:0060070,GO:0060174,GO:0060428,GO:0060439,GO:0060445,GO:0060447,GO:0060458,GO:0060459,GO:0060463,GO:0060484,GO:0060516,GO:0060523,GO:0060662,GO:0060664,GO:0060685,GO:0060738,GO:0060769,GO:0060782,GO:0060783,GO:0060840,GO:0060916,GO:0061053,GO:0061189,GO:0062023,GO:0071285,GO:0071542,GO:0072136,GO:0072205,GO:0090090,GO:0090370,GO:0097190,GO:1900175,GO:1900180,GO:1904339,GO:1905327,GO:2000062,GO:2000063,GO:2000357,GO:2000358,GO:2000729,GO:2001054" "negative regulation of transcription by RNA polymerase II|branching involved in blood vessel morphogenesis|vasculogenesis|metanephros development|branching involved in ureteric bud morphogenesis|cell fate specification|neural crest cell migration|heart looping|positive regulation of neuroblast proliferation|osteoblast development|lymphoid progenitor cell differentiation|determination of left/right asymmetry in lateral mesoderm|patched binding|calcium ion binding|protein binding|glycosaminoglycan binding|extracellular region|extracellular space|endoplasmic reticulum lumen|cytosol|plasma membrane|endocytosis|smoothened signaling pathway|positive regulation of hh target transcription factor activity|cell-cell signaling|pattern specification process|ectoderm development|neuroblast proliferation|axon guidance|central nervous system development|ventral midline development|hindgut morphogenesis|heart development|blood coagulation|androgen metabolic process|peptidase activity|zinc ion binding|positive regulation of cell population proliferation|embryonic pattern specification|polarity specification of anterior/posterior axis|dorsal/ventral pattern formation|cell surface|regulation of gene expression|oligodendrocyte development|striated muscle tissue development|positive regulation of skeletal muscle cell proliferation|myotube differentiation|morphogen activity|intein-mediated protein splicing|protein autoprocessing|spinal cord dorsal/ventral patterning|spinal cord motor neuron differentiation|thalamus development|dorsal/ventral neural tube patterning|cerebellar granule cell precursor proliferation|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|telencephalon regionalization|establishment of cell polarity|regulation of proteolysis|positive regulation of Wnt signaling pathway|lung development|embryonic limb morphogenesis|negative regulation of cell migration|male genitalia development|prostate gland development|thyroid gland development|forebrain development|midbrain development|hindbrain development|pancreas development|hair follicle morphogenesis|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|T cell differentiation in thymus|positive regulation of T cell differentiation in thymus|positive regulation of immature T cell proliferation in thymus|negative regulation of transcription elongation from RNA polymerase II promoter|protein localization to nucleus|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|regulation of cell population proliferation|negative regulation of T cell proliferation|positive regulation of protein import into nucleus|odontogenesis of dentin-containing tooth|regulation of odontogenesis|embryonic digit morphogenesis|camera-type eye development|negative regulation of apoptotic process|laminin-1 binding|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|positive thymic T cell selection|negative thymic T cell selection|intermediate filament organization|membrane raft|myoblast differentiation|negative regulation of cell differentiation|positive regulation of smoothened signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of alpha-beta T cell differentiation|negative regulation of alpha-beta T cell differentiation|cell development|thymus development|embryonic digestive tract morphogenesis|embryonic foregut morphogenesis|positive regulation of skeletal muscle tissue development|animal organ formation|neuron fate commitment|embryonic skeletal system development|oligodendrocyte differentiation|positive regulation of oligodendrocyte differentiation|smooth muscle tissue development|branching morphogenesis of an epithelial tube|inner ear development|formation of anatomical boundary|stem cell development|positive regulation of striated muscle cell differentiation|positive regulation of cell division|Bergmann glial cell differentiation|roof of mouth development|canonical Wnt signaling pathway|limb bud formation|lung epithelium development|trachea morphogenesis|branching involved in salivary gland morphogenesis|bud outgrowth involved in lung branching|right lung development|left lung development|lung lobe morphogenesis|lung-associated mesenchyme development|primary prostatic bud elongation|prostate epithelial cord elongation|salivary gland cavitation|epithelial cell proliferation involved in salivary gland morphogenesis|regulation of prostatic bud formation|epithelial-mesenchymal signaling involved in prostate gland development|positive regulation of epithelial cell proliferation involved in prostate gland development|regulation of mesenchymal cell proliferation involved in prostate gland development|mesenchymal smoothened signaling pathway involved in prostate gland development|artery development|mesenchymal cell proliferation involved in lung development|somite development|positive regulation of sclerotome development|collagen-containing extracellular matrix|cellular response to lithium ion|dopaminergic neuron differentiation|metanephric mesenchymal cell proliferation involved in metanephros development|metanephric collecting duct development|negative regulation of canonical Wnt signaling pathway|negative regulation of cholesterol efflux|apoptotic signaling pathway|regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|regulation of protein localization to nucleus|negative regulation of dopaminergic neuron differentiation|tracheoesophageal septum formation|negative regulation of ureter smooth muscle cell differentiation|positive regulation of ureter smooth muscle cell differentiation|negative regulation of kidney smooth muscle cell differentiation|positive regulation of kidney smooth muscle cell differentiation|positive regulation of mesenchymal cell proliferation involved in ureter development|negative regulation of mesenchymal cell apoptotic process" "hsa04340,hsa04360,hsa05200,hsa05205,hsa05217,hsa05226" Hedgehog signaling pathway|Axon guidance|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Gastric cancer SHISA2 324.576376 332.9324424 316.2203095 0.949803231 -0.074299431 0.817774625 1 4.621064382 4.315656205 387914 shisa family member 2 "GO:0005515,GO:0005783,GO:0005789,GO:0007275,GO:0016021,GO:0030178,GO:0040037" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|multicellular organism development|integral component of membrane|negative regulation of Wnt signaling pathway|negative regulation of fibroblast growth factor receptor signaling pathway SHISA3 82.019704 96.75849109 67.28091692 0.695348968 -0.524190904 0.298833798 1 2.223868577 1.5204884 152573 shisa family member 3 "GO:0005515,GO:0005789,GO:0007275,GO:0016021,GO:0090090" protein binding|endoplasmic reticulum membrane|multicellular organism development|integral component of membrane|negative regulation of canonical Wnt signaling pathway SHISA4 420.9637295 453.6204528 388.3070062 0.856017412 -0.224287952 0.434067233 1 16.90564934 14.22936874 149345 shisa family member 4 "GO:0005515,GO:0016021" protein binding|integral component of membrane SHISA5 3434.110698 3328.284011 3539.937386 1.063592342 0.088945295 0.708481818 1 54.33600505 56.82429875 51246 shisa family member 5 "GO:0005515,GO:0005783,GO:0005788,GO:0005789,GO:0016021,GO:0031965,GO:0042771,GO:0043123,GO:0043687,GO:0044267" protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral component of membrane|nuclear membrane|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of I-kappaB kinase/NF-kappaB signaling|post-translational protein modification|cellular protein metabolic process hsa04115 p53 signaling pathway SHISA8 34.19023353 27.05076095 41.32970611 1.52785743 0.611509927 0.386640309 1 0.257702498 0.387144093 440829 shisa family member 8 "GO:0014069,GO:0032281,GO:0032591,GO:0045211,GO:0048172,GO:2000311" postsynaptic density|AMPA glutamate receptor complex|dendritic spine membrane|postsynaptic membrane|regulation of short-term neuronal synaptic plasticity|regulation of AMPA receptor activity SHISAL1 8.085537281 10.40413883 5.766935736 0.554292463 -0.851280704 0.546153423 1 0.078736496 0.042912739 85352 shisa like 1 "GO:0005515,GO:0016021" protein binding|integral component of membrane SHKBP1 1548.952744 1565.822893 1532.082594 0.978452033 -0.031426968 0.89775723 1 34.63120181 33.31795074 92799 SH3KBP1 binding protein 1 "GO:0005515,GO:0005764,GO:0042802,GO:0045742,GO:0051260" protein binding|lysosome|identical protein binding|positive regulation of epidermal growth factor receptor signaling pathway|protein homooligomerization SHLD1 48.23582094 55.14193578 41.32970611 0.749514966 -0.41597081 0.506476842 1 0.676822393 0.498799727 149840 shieldin complex subunit 1 "GO:0005515,GO:0005694,GO:0006281,GO:0035861,GO:0045830,GO:2000042,GO:2001034" protein binding|chromosome|DNA repair|site of double-strand break|positive regulation of isotype switching|negative regulation of double-strand break repair via homologous recombination|positive regulation of double-strand break repair via nonhomologous end joining SHLD2 1497.332755 1560.620824 1434.044686 0.918893728 -0.122030075 0.610530749 1 13.67161278 12.35253847 54537 shieldin complex subunit 2 "GO:0005515,GO:0005634,GO:0005694,GO:0006281,GO:0010569,GO:0035861,GO:0045830,GO:2000042,GO:2001034" protein binding|nucleus|chromosome|DNA repair|regulation of double-strand break repair via homologous recombination|site of double-strand break|positive regulation of isotype switching|negative regulation of double-strand break repair via homologous recombination|positive regulation of double-strand break repair via nonhomologous end joining SHLD3 45.99647733 46.81862472 45.17432993 0.964879473 -0.051579355 0.972526606 1 1.621430209 1.538305192 112441434 shieldin complex subunit 3 "GO:0005515,GO:0005694,GO:0006281,GO:0035861,GO:0045830,GO:2000042,GO:2001034" protein binding|chromosome|DNA repair|site of double-strand break|positive regulation of isotype switching|negative regulation of double-strand break repair via homologous recombination|positive regulation of double-strand break repair via nonhomologous end joining SHMT1 1306.371534 1291.153628 1321.589439 1.023572571 0.033613393 0.892036251 1 26.22012789 26.38910274 6470 serine hydroxymethyltransferase 1 "GO:0000900,GO:0004372,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006544,GO:0006563,GO:0006565,GO:0006730,GO:0008270,GO:0008732,GO:0009113,GO:0017148,GO:0019264,GO:0030170,GO:0035999,GO:0036094,GO:0042802,GO:0042803,GO:0045329,GO:0046653,GO:0046655,GO:0048027,GO:0050897,GO:0051289,GO:0070062,GO:0070905,GO:1904482,GO:1990830" "translation repressor activity, mRNA regulatory element binding|glycine hydroxymethyltransferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|glycine metabolic process|L-serine metabolic process|L-serine catabolic process|one-carbon metabolic process|zinc ion binding|L-allo-threonine aldolase activity|purine nucleobase biosynthetic process|negative regulation of translation|glycine biosynthetic process from serine|pyridoxal phosphate binding|tetrahydrofolate interconversion|small molecule binding|identical protein binding|protein homodimerization activity|carnitine biosynthetic process|tetrahydrofolate metabolic process|folic acid metabolic process|mRNA 5'-UTR binding|cobalt ion binding|protein homotetramerization|extracellular exosome|serine binding|cellular response to tetrahydrofolate|cellular response to leukemia inhibitory factor" "hsa00260,hsa00630,hsa00670,hsa01523" "Glycine, serine and threonine metabolism|Glyoxylate and dicarboxylate metabolism|One carbon pool by folate|Antifolate resistance" SHMT2 5094.706103 5718.114699 4471.297507 0.781953099 -0.354846017 0.139823636 1 114.0804755 87.71284674 6472 serine hydroxymethyltransferase 2 "GO:0000900,GO:0002082,GO:0003682,GO:0004372,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005743,GO:0005758,GO:0005759,GO:0005829,GO:0006544,GO:0006563,GO:0006564,GO:0006565,GO:0006730,GO:0008270,GO:0008284,GO:0008732,GO:0009113,GO:0015630,GO:0017148,GO:0019264,GO:0030170,GO:0034340,GO:0035999,GO:0042645,GO:0042803,GO:0046653,GO:0046655,GO:0048027,GO:0050897,GO:0051262,GO:0051289,GO:0070062,GO:0070129,GO:0070536,GO:0070552,GO:0070905,GO:1903715" "translation repressor activity, mRNA regulatory element binding|regulation of oxidative phosphorylation|chromatin binding|glycine hydroxymethyltransferase activity|protein binding|nucleus|cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|cytosol|glycine metabolic process|L-serine metabolic process|L-serine biosynthetic process|L-serine catabolic process|one-carbon metabolic process|zinc ion binding|positive regulation of cell population proliferation|L-allo-threonine aldolase activity|purine nucleobase biosynthetic process|microtubule cytoskeleton|negative regulation of translation|glycine biosynthetic process from serine|pyridoxal phosphate binding|response to type I interferon|tetrahydrofolate interconversion|mitochondrial nucleoid|protein homodimerization activity|tetrahydrofolate metabolic process|folic acid metabolic process|mRNA 5'-UTR binding|cobalt ion binding|protein tetramerization|protein homotetramerization|extracellular exosome|regulation of mitochondrial translation|protein K63-linked deubiquitination|BRISC complex|serine binding|regulation of aerobic respiration" "hsa00260,hsa00630,hsa00670,hsa01523" "Glycine, serine and threonine metabolism|Glyoxylate and dicarboxylate metabolism|One carbon pool by folate|Antifolate resistance" SHOC1 3.121241648 6.242483296 0 0 #NAME? 0.093640883 1 0.041297863 0 158401 shortage in chiasmata 1 "GO:0000712,GO:0000794,GO:0003697,GO:0005694,GO:0007131,GO:0016887" resolution of meiotic recombination intermediates|condensed nuclear chromosome|single-stranded DNA binding|chromosome|reciprocal meiotic recombination|ATPase activity SHOC2 881.6172864 902.0388363 861.1957366 0.954721351 -0.066848371 0.792032331 1 11.62524869 10.91314852 8036 SHOC2 leucine rich repeat scaffold protein "GO:0000164,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0007265,GO:0008157,GO:0008543,GO:0019888,GO:0019903,GO:0043666,GO:0046579" protein phosphatase type 1 complex|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|signal transduction|Ras protein signal transduction|protein phosphatase 1 binding|fibroblast growth factor receptor signaling pathway|protein phosphatase regulator activity|protein phosphatase binding|regulation of phosphoprotein phosphatase activity|positive regulation of Ras protein signal transduction hsa04014 Ras signaling pathway SHOX2 8.486857333 8.323311061 8.650403604 1.039298368 0.055609892 1 1 0.113751553 0.116243521 6474 short stature homeobox 2 "GO:0000122,GO:0000785,GO:0000981,GO:0001501,GO:0001649,GO:0002053,GO:0002063,GO:0003170,GO:0003209,GO:0005634,GO:0006357,GO:0007399,GO:0007507,GO:0032330,GO:0035115,GO:0045880,GO:0048557,GO:0048743,GO:0050772,GO:0060272,GO:0060351,GO:0060415,GO:0060931,GO:1990837,GO:2000172" "negative regulation of transcription by RNA polymerase II|chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|skeletal system development|osteoblast differentiation|positive regulation of mesenchymal cell proliferation|chondrocyte development|heart valve development|cardiac atrium morphogenesis|nucleus|regulation of transcription by RNA polymerase II|nervous system development|heart development|regulation of chondrocyte differentiation|embryonic forelimb morphogenesis|positive regulation of smoothened signaling pathway|embryonic digestive tract morphogenesis|positive regulation of skeletal muscle fiber development|positive regulation of axonogenesis|embryonic skeletal joint morphogenesis|cartilage development involved in endochondral bone morphogenesis|muscle tissue morphogenesis|sinoatrial node cell development|sequence-specific double-stranded DNA binding|regulation of branching morphogenesis of a nerve" SHPK 1455.791042 1391.033361 1520.548722 1.093107301 0.128435024 0.592407507 1 19.59791285 21.06414305 23729 sedoheptulokinase "GO:0005524,GO:0005737,GO:0005829,GO:0005975,GO:0006098,GO:0009052,GO:0016310,GO:0016773,GO:0035963,GO:0043030,GO:0050277,GO:0050727,GO:0071222,GO:0071353" "ATP binding|cytoplasm|cytosol|carbohydrate metabolic process|pentose-phosphate shunt|pentose-phosphate shunt, non-oxidative branch|phosphorylation|phosphotransferase activity, alcohol group as acceptor|cellular response to interleukin-13|regulation of macrophage activation|sedoheptulokinase activity|regulation of inflammatory response|cellular response to lipopolysaccharide|cellular response to interleukin-4" SHPRH 352.8210363 405.7614142 299.8806583 0.739056617 -0.436243205 0.145235029 1 1.339275213 0.973237243 257218 SNF2 histone linker PHD RING helicase "GO:0000209,GO:0000786,GO:0003677,GO:0004386,GO:0004842,GO:0005515,GO:0005524,GO:0005654,GO:0006281,GO:0006334,GO:0006974,GO:0016567,GO:0031625,GO:0046872,GO:0061630" protein polyubiquitination|nucleosome|DNA binding|helicase activity|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleoplasm|DNA repair|nucleosome assembly|cellular response to DNA damage stimulus|protein ubiquitination|ubiquitin protein ligase binding|metal ion binding|ubiquitin protein ligase activity SHQ1 317.2192513 303.8008537 330.6376489 1.0883368 0.122125086 0.700255387 1 2.472669392 2.646065227 55164 "SHQ1, H/ACA ribonucleoprotein assembly factor" "GO:0000493,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0015030,GO:0022618,GO:0043065,GO:0051082,GO:1904874,GO:2000233" box H/ACA snoRNP assembly|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|Cajal body|ribonucleoprotein complex assembly|positive regulation of apoptotic process|unfolded protein binding|positive regulation of telomerase RNA localization to Cajal body|negative regulation of rRNA processing SHROOM1 216.8136668 216.4060876 217.2212461 1.0037668 0.005424134 1 1 2.378335082 2.347345666 134549 shroom family member 1 "GO:0000902,GO:0005874,GO:0005912,GO:0007015,GO:0016324,GO:0030864,GO:0043296,GO:0045159,GO:0051015,GO:0051017" cell morphogenesis|microtubule|adherens junction|actin filament organization|apical plasma membrane|cortical actin cytoskeleton|apical junction complex|myosin II binding|actin filament binding|actin filament bundle assembly SHROOM2 40.22451117 59.30359131 21.14543103 0.356562403 -1.487773505 0.023470037 0.846928903 0.384512656 0.134808528 357 shroom family member 2 "GO:0000902,GO:0002089,GO:0003779,GO:0005515,GO:0005856,GO:0005874,GO:0005886,GO:0005912,GO:0005923,GO:0007015,GO:0007420,GO:0008013,GO:0008057,GO:0015280,GO:0016324,GO:0016477,GO:0030864,GO:0032401,GO:0032438,GO:0035725,GO:0043010,GO:0043296,GO:0043482,GO:0043583,GO:0045176,GO:0048593,GO:0051015,GO:0051017,GO:0070062" cell morphogenesis|lens morphogenesis in camera-type eye|actin binding|protein binding|cytoskeleton|microtubule|plasma membrane|adherens junction|bicellular tight junction|actin filament organization|brain development|beta-catenin binding|eye pigment granule organization|ligand-gated sodium channel activity|apical plasma membrane|cell migration|cortical actin cytoskeleton|establishment of melanosome localization|melanosome organization|sodium ion transmembrane transport|camera-type eye development|apical junction complex|cellular pigment accumulation|ear development|apical protein localization|camera-type eye morphogenesis|actin filament binding|actin filament bundle assembly|extracellular exosome SHROOM3 524.4905556 547.2577023 501.723409 0.916795519 -0.125328103 0.647282997 1 2.681676407 2.417408426 57619 shroom family member 3 "GO:0000902,GO:0001843,GO:0002064,GO:0005856,GO:0005874,GO:0005912,GO:0007015,GO:0007389,GO:0008360,GO:0016324,GO:0030864,GO:0043296,GO:0043482,GO:0045176,GO:0051015" cell morphogenesis|neural tube closure|epithelial cell development|cytoskeleton|microtubule|adherens junction|actin filament organization|pattern specification process|regulation of cell shape|apical plasma membrane|cortical actin cytoskeleton|apical junction complex|cellular pigment accumulation|apical protein localization|actin filament binding SHROOM4 114.6493167 120.6880104 108.610623 0.899928855 -0.152117143 0.748210928 1 0.615529176 0.544663157 57477 shroom family member 4 "GO:0000902,GO:0001725,GO:0005654,GO:0005737,GO:0005884,GO:0005912,GO:0005925,GO:0007015,GO:0007420,GO:0009898,GO:0009925,GO:0015629,GO:0016324,GO:0030036,GO:0030864,GO:0043231,GO:0043296,GO:0045159,GO:0050890,GO:0051015" cell morphogenesis|stress fiber|nucleoplasm|cytoplasm|actin filament|adherens junction|focal adhesion|actin filament organization|brain development|cytoplasmic side of plasma membrane|basal plasma membrane|actin cytoskeleton|apical plasma membrane|actin cytoskeleton organization|cortical actin cytoskeleton|intracellular membrane-bounded organelle|apical junction complex|myosin II binding|cognition|actin filament binding SHTN1 1391.085393 1559.58041 1222.590376 0.78392263 -0.351216823 0.142654191 1 5.555091777 4.281891106 57698 shootin 1 "GO:0005515,GO:0005737,GO:0005874,GO:0005875,GO:0006930,GO:0007265,GO:0007409,GO:0015630,GO:0019894,GO:0030027,GO:0030175,GO:0030424,GO:0030426,GO:0031252,GO:0032488,GO:0038007,GO:0043204,GO:0044295,GO:0045296,GO:0045773,GO:0048471,GO:0048812,GO:0051015,GO:0060327,GO:0061163,GO:0061573,GO:2000114,GO:2001224" "protein binding|cytoplasm|microtubule|microtubule associated complex|substrate-dependent cell migration, cell extension|Ras protein signal transduction|axonogenesis|microtubule cytoskeleton|kinesin binding|lamellipodium|filopodium|axon|growth cone|cell leading edge|Cdc42 protein signal transduction|netrin-activated signaling pathway|perikaryon|axonal growth cone|cadherin binding|positive regulation of axon extension|perinuclear region of cytoplasm|neuron projection morphogenesis|actin filament binding|cytoplasmic actin-based contraction involved in cell motility|endoplasmic reticulum polarization|actin filament bundle retrograde transport|regulation of establishment of cell polarity|positive regulation of neuron migration" SIAE 683.1844696 688.7539903 677.614949 0.983827257 -0.023523069 0.933140081 1 4.337684044 4.196120429 54414 sialic acid acetylesterase "GO:0001681,GO:0002682,GO:0005615,GO:0005764,GO:0005975,GO:0070062,GO:0106330,GO:0106331" sialate O-acetylesterase activity|regulation of immune system process|extracellular space|lysosome|carbohydrate metabolic process|extracellular exosome|sialate 9-O-acetylesterase activity|sialate 4-O-acetylesterase activity SIAH1 374.0608165 370.3873422 377.7342907 1.019835852 0.028336961 0.933056343 1 2.094616055 2.100418728 6477 siah E3 ubiquitin protein ligase 1 "GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005769,GO:0005829,GO:0005886,GO:0006511,GO:0006915,GO:0007049,GO:0007283,GO:0007399,GO:0007411,GO:0008022,GO:0008270,GO:0009653,GO:0030163,GO:0030877,GO:0031624,GO:0031648,GO:0042802,GO:0043065,GO:0043161,GO:0044267,GO:0051402,GO:0061630,GO:1902842,GO:2001244" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|early endosome|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|apoptotic process|cell cycle|spermatogenesis|nervous system development|axon guidance|protein C-terminus binding|zinc ion binding|anatomical structure morphogenesis|protein catabolic process|beta-catenin destruction complex|ubiquitin conjugating enzyme binding|protein destabilization|identical protein binding|positive regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|cellular protein metabolic process|neuron apoptotic process|ubiquitin protein ligase activity|negative regulation of netrin-activated signaling pathway|positive regulation of intrinsic apoptotic signaling pathway "hsa04115,hsa04120,hsa04310" p53 signaling pathway|Ubiquitin mediated proteolysis|Wnt signaling pathway SIAH2 529.6825642 582.6317743 476.7333542 0.818241255 -0.289401816 0.283967137 1 13.45477584 10.82502773 6478 siah E3 ubiquitin protein ligase 2 "GO:0000209,GO:0003714,GO:0004842,GO:0005515,GO:0005654,GO:0005737,GO:0005769,GO:0005829,GO:0006511,GO:0006915,GO:0007049,GO:0007264,GO:0007275,GO:0008270,GO:0016579,GO:0031396,GO:0031624,GO:0042752,GO:0043005,GO:0043025,GO:0043066,GO:0043154,GO:0043161,GO:0043231,GO:0044257,GO:0044267,GO:0045892,GO:0048511,GO:0061630,GO:0090090,GO:1902842,GO:2001237" "protein polyubiquitination|transcription corepressor activity|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytoplasm|early endosome|cytosol|ubiquitin-dependent protein catabolic process|apoptotic process|cell cycle|small GTPase mediated signal transduction|multicellular organism development|zinc ion binding|protein deubiquitination|regulation of protein ubiquitination|ubiquitin conjugating enzyme binding|regulation of circadian rhythm|neuron projection|neuronal cell body|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|cellular protein catabolic process|cellular protein metabolic process|negative regulation of transcription, DNA-templated|rhythmic process|ubiquitin protein ligase activity|negative regulation of canonical Wnt signaling pathway|negative regulation of netrin-activated signaling pathway|negative regulation of extrinsic apoptotic signaling pathway" SIDT1 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.031182128 0 54847 SID1 transmembrane family member 1 "GO:0003725,GO:0005764,GO:0005886,GO:0015485,GO:0016021,GO:0050658,GO:0051033" double-stranded RNA binding|lysosome|plasma membrane|cholesterol binding|integral component of membrane|RNA transport|RNA transmembrane transporter activity SIDT2 496.2106825 561.8234966 430.5978683 0.766429085 -0.383775785 0.160889531 1 6.820629533 5.140053234 51092 SID1 transmembrane family member 2 "GO:0003677,GO:0003725,GO:0005764,GO:0005765,GO:0005886,GO:0006401,GO:0016021,GO:0035612,GO:0035650,GO:0050658,GO:0051032,GO:0051033" DNA binding|double-stranded RNA binding|lysosome|lysosomal membrane|plasma membrane|RNA catabolic process|integral component of membrane|AP-2 adaptor complex binding|AP-1 adaptor complex binding|RNA transport|nucleic acid transmembrane transporter activity|RNA transmembrane transporter activity SIGIRR 354.8873871 346.4578229 363.3169514 1.048661417 0.068548947 0.827339981 1 8.660335947 8.929789205 59307 single Ig and TIR domain containing "GO:0001960,GO:0005515,GO:0005886,GO:0006953,GO:0007165,GO:0016020,GO:0016021,GO:0031665,GO:0032682,GO:0043433,GO:0071345" negative regulation of cytokine-mediated signaling pathway|protein binding|plasma membrane|acute-phase response|signal transduction|membrane|integral component of membrane|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of chemokine production|negative regulation of DNA-binding transcription factor activity|cellular response to cytokine stimulus SIGLEC15 1635.431013 1729.167873 1541.694153 0.891581539 -0.16556135 0.48700237 1 31.30342989 27.4425315 284266 sialic acid binding Ig like lectin 15 "GO:0005886,GO:0016021,GO:0032956,GO:0032991,GO:0045087,GO:0045124,GO:2001204" plasma membrane|integral component of membrane|regulation of actin cytoskeleton organization|protein-containing complex|innate immune response|regulation of bone resorption|regulation of osteoclast development SIGMAR1 1704.678901 1717.72332 1691.634483 0.984811967 -0.022079801 0.928476823 1 54.08362039 52.37092587 10280 sigma non-opioid intracellular receptor 1 "GO:0004985,GO:0005515,GO:0005635,GO:0005637,GO:0005640,GO:0005783,GO:0005789,GO:0005811,GO:0006869,GO:0007399,GO:0014069,GO:0016020,GO:0016021,GO:0030426,GO:0031410,GO:0036474,GO:0038003,GO:0043523,GO:0070207,GO:0098839" opioid receptor activity|protein binding|nuclear envelope|nuclear inner membrane|nuclear outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|lipid transport|nervous system development|postsynaptic density|membrane|integral component of membrane|growth cone|cytoplasmic vesicle|cell death in response to hydrogen peroxide|opioid receptor signaling pathway|regulation of neuron apoptotic process|protein homotrimerization|postsynaptic density membrane "hsa05014,hsa05022" Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases SIK1 30.82618768 27.05076095 34.60161442 1.279136453 0.355170173 0.649096864 1 0.304438928 0.382902532 150094 salt inducible kinase 1 "GO:0000287,GO:0002028,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0007049,GO:0007346,GO:0008140,GO:0010830,GO:0010868,GO:0019901,GO:0032792,GO:0035556,GO:0042149,GO:0043153,GO:0045595,GO:0045721,GO:0046777,GO:0048511,GO:0055007,GO:0071889,GO:0106310,GO:0106311,GO:2000210" magnesium ion binding|regulation of sodium ion transport|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|cell cycle|regulation of mitotic cell cycle|cAMP response element binding protein binding|regulation of myotube differentiation|negative regulation of triglyceride biosynthetic process|protein kinase binding|negative regulation of CREB transcription factor activity|intracellular signal transduction|cellular response to glucose starvation|entrainment of circadian clock by photoperiod|regulation of cell differentiation|negative regulation of gluconeogenesis|protein autophosphorylation|rhythmic process|cardiac muscle cell differentiation|14-3-3 protein binding|protein serine kinase activity|protein threonine kinase activity|positive regulation of anoikis hsa04922 Glucagon signaling pathway SIK1B 198.9976831 202.8807071 195.1146591 0.961721111 -0.056309506 0.890885914 1 2.293448519 2.168749161 102724428 salt inducible kinase 1B (putative) "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0035556,GO:0042149,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|intracellular signal transduction|cellular response to glucose starvation|protein serine kinase activity|protein threonine kinase activity hsa04922 Glucagon signaling pathway SIK2 578.1762806 594.076327 562.2762343 0.946471369 -0.079369231 0.769722991 1 6.192336271 5.76279528 23235 salt inducible kinase 2 "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0035556,GO:0042149,GO:0046626,GO:0046777,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|intracellular signal transduction|cellular response to glucose starvation|regulation of insulin receptor signaling pathway|protein autophosphorylation|protein serine kinase activity|protein threonine kinase activity hsa04922 Glucagon signaling pathway SIK3 416.0636006 488.9945248 343.1326763 0.701710671 -0.511051792 0.073857618 1 3.099375185 2.138471227 23387 SIK family kinase 3 "GO:0000226,GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0035556,GO:0050321,GO:0106310,GO:0106311,GO:1904263,GO:1904515" microtubule cytoskeleton organization|magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|protein phosphorylation|intracellular signal transduction|tau-protein kinase activity|protein serine kinase activity|protein threonine kinase activity|positive regulation of TORC1 signaling|positive regulation of TORC2 signaling SIKE1 1238.585501 1252.658315 1224.512688 0.977531282 -0.032785224 0.89534044 1 12.14167671 11.67025935 80143 suppressor of IKBKE 1 "GO:0005515,GO:0005829,GO:0019901,GO:0031267" protein binding|cytosol|protein kinase binding|small GTPase binding hsa04622 RIG-I-like receptor signaling pathway SIL1 525.3428856 519.1665274 531.5192437 1.02379336 0.033924555 0.907351532 1 12.85705957 12.94270771 64374 SIL1 nucleotide exchange factor "GO:0000774,GO:0005515,GO:0005615,GO:0005783,GO:0005788,GO:0006457,GO:0006613,GO:0006886,GO:0050790,GO:0051082" adenyl-nucleotide exchange factor activity|protein binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|protein folding|cotranslational protein targeting to membrane|intracellular protein transport|regulation of catalytic activity|unfolded protein binding hsa04141 Protein processing in endoplasmic reticulum SIM1 4.885037707 2.080827765 7.689247648 3.695283087 1.88568489 0.299624042 1 0.013069313 0.047486663 6492 SIM bHLH transcription factor 1 "GO:0000785,GO:0000977,GO:0000981,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0007399,GO:0030154,GO:0046982" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|nervous system development|cell differentiation|protein heterodimerization activity" SIM2 555.7532763 484.8328693 626.6736833 1.292556101 0.3702269 0.165735342 1 4.459606886 5.667834467 6493 SIM bHLH transcription factor 2 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0003677,GO:0003700,GO:0005654,GO:0006357,GO:0007399,GO:0009880,GO:0016604,GO:0030154,GO:0030324,GO:0046982" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleoplasm|regulation of transcription by RNA polymerase II|nervous system development|embryonic pattern specification|nuclear body|cell differentiation|lung development|protein heterodimerization activity" SIMC1 154.9631466 157.1024963 152.823797 0.972764919 -0.039836894 0.937960983 1 1.001107043 0.957545887 375484 SUMO interacting motifs containing 1 "GO:0005515,GO:0005737,GO:0010466,GO:0030017,GO:0030414,GO:0032184" protein binding|cytoplasm|negative regulation of peptidase activity|sarcomere|peptidase inhibitor activity|SUMO polymer binding SIN3A 1887.732608 2031.928313 1743.536904 0.858070087 -0.220832603 0.35136214 1 14.57530639 12.29735283 25942 SIN3 transcription regulator family member A "GO:0000118,GO:0000122,GO:0000776,GO:0000785,GO:0001102,GO:0001103,GO:0001701,GO:0002218,GO:0002230,GO:0002244,GO:0003677,GO:0003682,GO:0003713,GO:0003714,GO:0003723,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006260,GO:0006476,GO:0007568,GO:0010817,GO:0010971,GO:0016575,GO:0016580,GO:0017053,GO:0019216,GO:0021895,GO:0030516,GO:0031937,GO:0034613,GO:0042754,GO:0043066,GO:0043619,GO:0044877,GO:0045652,GO:0045666,GO:0045892,GO:0045944,GO:0048511,GO:0051595,GO:0071333,GO:0140416,GO:1900181,GO:1901675,GO:1903351,GO:2000678" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|kinetochore|chromatin|RNA polymerase II activating transcription factor binding|RNA polymerase II repressing transcription factor binding|in utero embryonic development|activation of innate immune response|positive regulation of defense response to virus by host|hematopoietic progenitor cell differentiation|DNA binding|chromatin binding|transcription coactivator activity|transcription corepressor activity|RNA binding|histone deacetylase activity|protein binding|nucleus|nucleoplasm|nucleolus|DNA replication|protein deacetylation|aging|regulation of hormone levels|positive regulation of G2/M transition of mitotic cell cycle|histone deacetylation|Sin3 complex|transcription repressor complex|regulation of lipid metabolic process|cerebral cortex neuron differentiation|regulation of axon extension|positive regulation of chromatin silencing|cellular protein localization|negative regulation of circadian rhythm|negative regulation of apoptotic process|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|protein-containing complex binding|regulation of megakaryocyte differentiation|positive regulation of neuron differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|rhythmic process|response to methylglyoxal|cellular response to glucose stimulus|transcription regulator inhibitor activity|negative regulation of protein localization to nucleus|negative regulation of histone H3-K27 acetylation|cellular response to dopamine|negative regulation of transcription regulatory region DNA binding" "hsa04919,hsa05016,hsa05169,hsa05202" Thyroid hormone signaling pathway|Huntington disease|Epstein-Barr virus infection|Transcriptional misregulation in cancer other SIN3B 1387.543938 1403.518328 1371.569549 0.97723665 -0.033220123 0.89270876 1 13.50580483 12.97751067 23309 SIN3 transcription regulator family member B "GO:0000118,GO:0000122,GO:0000785,GO:0000805,GO:0000806,GO:0001741,GO:0003682,GO:0003714,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0016575,GO:0016580,GO:0019216,GO:0030849" histone deacetylase complex|negative regulation of transcription by RNA polymerase II|chromatin|X chromosome|Y chromosome|XY body|chromatin binding|transcription corepressor activity|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|histone deacetylation|Sin3 complex|regulation of lipid metabolic process|autosome SINHCAF 2029.636476 2098.514801 1960.75815 0.934355168 -0.097957042 0.680058829 1 32.64175985 29.9886376 58516 SIN3-HDAC complex associated factor "GO:0005515,GO:0008284,GO:0016580,GO:0030336,GO:0045596" protein binding|positive regulation of cell population proliferation|Sin3 complex|negative regulation of cell migration|negative regulation of cell differentiation SIPA1 1641.338186 1480.508955 1802.167417 1.217262085 0.283639824 0.232986352 1 20.50130822 24.53786927 6494 signal-induced proliferation-associated 1 "GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007010,GO:0007162,GO:0007165,GO:0008022,GO:0016020,GO:0030133,GO:0030308,GO:0032991,GO:0035556,GO:0042631,GO:0045786,GO:0048471,GO:0051056,GO:0090630" GTPase activator activity|protein binding|nucleus|cytoplasm|cytosol|cytoskeleton organization|negative regulation of cell adhesion|signal transduction|protein C-terminus binding|membrane|transport vesicle|negative regulation of cell growth|protein-containing complex|intracellular signal transduction|cellular response to water deprivation|negative regulation of cell cycle|perinuclear region of cytoplasm|regulation of small GTPase mediated signal transduction|activation of GTPase activity "hsa04015,hsa04670" Rap1 signaling pathway|Leukocyte transendothelial migration SIPA1L1 1609.31184 1649.056004 1569.567676 0.951797678 -0.071273159 0.766501521 1 7.834691364 7.332257568 26037 signal induced proliferation associated 1 like 1 "GO:0003674,GO:0005096,GO:0005575,GO:0005737,GO:0005886,GO:0008150,GO:0014069,GO:0015629,GO:0031532,GO:0043087,GO:0043197,GO:0046875,GO:0048013,GO:0048167,GO:0048814,GO:0050770,GO:0051056,GO:0061001,GO:0090630" molecular_function|GTPase activator activity|cellular_component|cytoplasm|plasma membrane|biological_process|postsynaptic density|actin cytoskeleton|actin cytoskeleton reorganization|regulation of GTPase activity|dendritic spine|ephrin receptor binding|ephrin receptor signaling pathway|regulation of synaptic plasticity|regulation of dendrite morphogenesis|regulation of axonogenesis|regulation of small GTPase mediated signal transduction|regulation of dendritic spine morphogenesis|activation of GTPase activity hsa04015 Rap1 signaling pathway SIPA1L2 67.92442679 92.59683556 43.25201802 0.46710039 -1.098195445 0.041082834 1 0.700456829 0.321708683 57568 signal induced proliferation associated 1 like 2 "GO:0005096,GO:0005575,GO:0005737,GO:0008150,GO:0051056,GO:0090630" GTPase activator activity|cellular_component|cytoplasm|biological_process|regulation of small GTPase mediated signal transduction|activation of GTPase activity hsa04015 Rap1 signaling pathway SIPA1L3 2116.551893 2071.46404 2161.639745 1.043532353 0.06147533 0.796503169 1 11.16556193 11.45665095 23094 signal induced proliferation associated 1 like 3 "GO:0001654,GO:0001725,GO:0002244,GO:0003382,GO:0005096,GO:0005515,GO:0005615,GO:0005654,GO:0005737,GO:0005794,GO:0005886,GO:0007010,GO:0016324,GO:0045177,GO:0051056,GO:0061689,GO:0090162,GO:0090630" eye development|stress fiber|hematopoietic progenitor cell differentiation|epithelial cell morphogenesis|GTPase activator activity|protein binding|extracellular space|nucleoplasm|cytoplasm|Golgi apparatus|plasma membrane|cytoskeleton organization|apical plasma membrane|apical part of cell|regulation of small GTPase mediated signal transduction|tricellular tight junction|establishment of epithelial cell polarity|activation of GTPase activity hsa04015 Rap1 signaling pathway SIRPA 726.7428442 822.9673812 630.5183071 0.766152246 -0.38429699 0.131378591 1 9.467612973 7.132253216 140885 signal regulatory protein alpha "GO:0001933,GO:0005886,GO:0005887,GO:0007155,GO:0009986,GO:0010468,GO:0016020,GO:0016477,GO:0017124,GO:0019903,GO:0030695,GO:0032649,GO:0032651,GO:0032675,GO:0032680,GO:0032688,GO:0032715,GO:0032720,GO:0034113,GO:0035696,GO:0043312,GO:0045019,GO:0045428,GO:0046329,GO:0050728,GO:0050765,GO:0050766,GO:0050790,GO:0050870,GO:0050900,GO:0070062,GO:0070301,GO:0070373,GO:0070821,GO:0071222,GO:0071346,GO:0071347,GO:0071349,GO:0071641,GO:0071650,GO:0086080,GO:0098632,GO:0101003,GO:1900016,GO:1903720,GO:1990405,GO:1990782" negative regulation of protein phosphorylation|plasma membrane|integral component of plasma membrane|cell adhesion|cell surface|regulation of gene expression|membrane|cell migration|SH3 domain binding|protein phosphatase binding|GTPase regulator activity|regulation of interferon-gamma production|regulation of interleukin-1 beta production|regulation of interleukin-6 production|regulation of tumor necrosis factor production|negative regulation of interferon-beta production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|heterotypic cell-cell adhesion|monocyte extravasation|neutrophil degranulation|negative regulation of nitric oxide biosynthetic process|regulation of nitric oxide biosynthetic process|negative regulation of JNK cascade|negative regulation of inflammatory response|negative regulation of phagocytosis|positive regulation of phagocytosis|regulation of catalytic activity|positive regulation of T cell activation|leukocyte migration|extracellular exosome|cellular response to hydrogen peroxide|negative regulation of ERK1 and ERK2 cascade|tertiary granule membrane|cellular response to lipopolysaccharide|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to interleukin-12|negative regulation of macrophage inflammatory protein 1 alpha production|negative regulation of chemokine (C-C motif) ligand 5 production|protein binding involved in heterotypic cell-cell adhesion|cell-cell adhesion mediator activity|ficolin-1-rich granule membrane|negative regulation of cytokine production involved in inflammatory response|negative regulation of I-kappaB phosphorylation|protein antigen binding|protein tyrosine kinase binding hsa04380 Osteoclast differentiation SIRPB1 3831.794793 4407.193207 3256.396379 0.738882147 -0.436583825 0.066649215 1 24.21037585 17.58927275 10326 signal regulatory protein beta 1 "GO:0005515,GO:0005886,GO:0005887,GO:0007165,GO:0007166,GO:0009986,GO:0030667,GO:0043312,GO:0045087,GO:0050766,GO:0050870" protein binding|plasma membrane|integral component of plasma membrane|signal transduction|cell surface receptor signaling pathway|cell surface|secretory granule membrane|neutrophil degranulation|innate immune response|positive regulation of phagocytosis|positive regulation of T cell activation hsa04380 Osteoclast differentiation SIRPB2 17.48889119 30.1720026 4.80577978 0.159279443 -2.65036801 0.006393045 0.47773166 0.363153885 0.056875025 284759 signal regulatory protein beta 2 "GO:0005886,GO:0016021" plasma membrane|integral component of membrane SIRPD 114.4014821 139.4154603 89.38750391 0.641159192 -0.641245489 0.150854588 1 9.073593756 5.720268085 128646 signal regulatory protein delta "GO:0005576,GO:0005886" extracellular region|plasma membrane SIRT1 1180.479611 1342.133909 1018.825313 0.759108541 -0.397621911 0.10091578 1 16.09238822 12.01145331 23411 sirtuin 1 "GO:0000012,GO:0000122,GO:0000183,GO:0000720,GO:0000731,GO:0000785,GO:0000791,GO:0000792,GO:0000978,GO:0001525,GO:0001542,GO:0001650,GO:0001678,GO:0001934,GO:0001938,GO:0002039,GO:0002821,GO:0003713,GO:0003714,GO:0003950,GO:0004407,GO:0005515,GO:0005634,GO:0005635,GO:0005637,GO:0005654,GO:0005677,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0006325,GO:0006346,GO:0006471,GO:0006476,GO:0006642,GO:0006974,GO:0006979,GO:0007179,GO:0007283,GO:0007346,GO:0007517,GO:0007569,GO:0008022,GO:0008134,GO:0008284,GO:0009267,GO:0010629,GO:0010824,GO:0010875,GO:0010883,GO:0010906,GO:0010934,GO:0014068,GO:0016032,GO:0016239,GO:0016567,GO:0016575,GO:0016605,GO:0017136,GO:0018394,GO:0019213,GO:0019899,GO:0030225,GO:0030308,GO:0030512,GO:0031393,GO:0031507,GO:0031648,GO:0032007,GO:0032071,GO:0032088,GO:0032868,GO:0032922,GO:0033210,GO:0033553,GO:0033558,GO:0034391,GO:0034979,GO:0034983,GO:0035098,GO:0035257,GO:0035356,GO:0035358,GO:0042127,GO:0042326,GO:0042393,GO:0042542,GO:0042595,GO:0042632,GO:0042771,GO:0042802,GO:0042981,GO:0043065,GO:0043066,GO:0043124,GO:0043161,GO:0043280,GO:0043398,GO:0043425,GO:0043433,GO:0043518,GO:0043536,GO:0044321,GO:0045348,GO:0045599,GO:0045722,GO:0045739,GO:0045766,GO:0045892,GO:0045944,GO:0046628,GO:0046872,GO:0046969,GO:0050872,GO:0051019,GO:0051097,GO:0051152,GO:0051574,GO:0051898,GO:0055089,GO:0060766,GO:0061647,GO:0070301,GO:0070403,GO:0070829,GO:0070857,GO:0070914,GO:0070932,GO:0071356,GO:0071441,GO:0071456,GO:0071479,GO:0071900,GO:0090335,GO:0090400,GO:0106230,GO:0106231,GO:1900034,GO:1900113,GO:1901215,GO:1901984,GO:1902166,GO:1902176,GO:1902237,GO:1904179,GO:1990254,GO:1990619,GO:1990830,GO:1990841,GO:2000111,GO:2000480,GO:2000481,GO:2000619,GO:2000655,GO:2000757,GO:2000773,GO:2000774" "single strand break repair|negative regulation of transcription by RNA polymerase II|rDNA heterochromatin assembly|pyrimidine dimer repair by nucleotide-excision repair|DNA synthesis involved in DNA repair|chromatin|euchromatin|heterochromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|angiogenesis|ovulation from ovarian follicle|fibrillar center|cellular glucose homeostasis|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|p53 binding|positive regulation of adaptive immune response|transcription coactivator activity|transcription corepressor activity|NAD+ ADP-ribosyltransferase activity|histone deacetylase activity|protein binding|nucleus|nuclear envelope|nuclear inner membrane|nucleoplasm|chromatin silencing complex|nucleolus|cytoplasm|mitochondrion|cytosol|chromatin organization|DNA methylation-dependent heterochromatin assembly|protein ADP-ribosylation|protein deacetylation|triglyceride mobilization|cellular response to DNA damage stimulus|response to oxidative stress|transforming growth factor beta receptor signaling pathway|spermatogenesis|regulation of mitotic cell cycle|muscle organ development|cell aging|protein C-terminus binding|transcription factor binding|positive regulation of cell population proliferation|cellular response to starvation|negative regulation of gene expression|regulation of centrosome duplication|positive regulation of cholesterol efflux|regulation of lipid storage|regulation of glucose metabolic process|macrophage cytokine production|positive regulation of phosphatidylinositol 3-kinase signaling|viral process|positive regulation of macroautophagy|protein ubiquitination|histone deacetylation|PML body|NAD-dependent histone deacetylase activity|peptidyl-lysine acetylation|deacetylase activity|enzyme binding|macrophage differentiation|negative regulation of cell growth|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of prostaglandin biosynthetic process|heterochromatin assembly|protein destabilization|negative regulation of TOR signaling|regulation of endodeoxyribonuclease activity|negative regulation of NF-kappaB transcription factor activity|response to insulin|circadian regulation of gene expression|leptin-mediated signaling pathway|rDNA heterochromatin|protein deacetylase activity|regulation of smooth muscle cell apoptotic process|NAD-dependent protein deacetylase activity|peptidyl-lysine deacetylation|ESC/E(Z) complex|nuclear hormone receptor binding|cellular triglyceride homeostasis|regulation of peroxisome proliferator activated receptor signaling pathway|regulation of cell population proliferation|negative regulation of phosphorylation|histone binding|response to hydrogen peroxide|behavioral response to starvation|cholesterol homeostasis|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of I-kappaB kinase/NF-kappaB signaling|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|HLH domain binding|bHLH transcription factor binding|negative regulation of DNA-binding transcription factor activity|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of blood vessel endothelial cell migration|response to leptin|positive regulation of MHC class II biosynthetic process|negative regulation of fat cell differentiation|positive regulation of gluconeogenesis|positive regulation of DNA repair|positive regulation of angiogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of insulin receptor signaling pathway|metal ion binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|white fat cell differentiation|mitogen-activated protein kinase binding|negative regulation of helicase activity|positive regulation of smooth muscle cell differentiation|positive regulation of histone H3-K9 methylation|negative regulation of protein kinase B signaling|fatty acid homeostasis|negative regulation of androgen receptor signaling pathway|histone H3-K9 modification|cellular response to hydrogen peroxide|NAD+ binding|heterochromatin maintenance|regulation of bile acid biosynthetic process|UV-damage excision repair|histone H3 deacetylation|cellular response to tumor necrosis factor|negative regulation of histone H3-K14 acetylation|cellular response to hypoxia|cellular response to ionizing radiation|regulation of protein serine/threonine kinase activity|regulation of brown fat cell differentiation|stress-induced premature senescence|protein depropionylation|protein-propionyllysine depropionylase activity|regulation of cellular response to heat|negative regulation of histone H3-K9 trimethylation|negative regulation of neuron death|negative regulation of protein acetylation|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of adipose tissue development|keratin filament binding|histone H3-K9 deacetylation|cellular response to leukemia inhibitory factor|promoter-specific chromatin binding|positive regulation of macrophage apoptotic process|negative regulation of cAMP-dependent protein kinase activity|positive regulation of cAMP-dependent protein kinase activity|negative regulation of histone H4-K16 acetylation|negative regulation of cellular response to testosterone stimulus|negative regulation of peptidyl-lysine acetylation|negative regulation of cellular senescence|positive regulation of cellular senescence" "hsa00760,hsa04068,hsa04152,hsa04211,hsa04213,hsa04218,hsa04922,hsa05031,hsa05206" Nicotinate and nicotinamide metabolism|FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Glucagon signaling pathway|Amphetamine addiction|MicroRNAs in cancer SIRT2 565.3000548 546.2172884 584.3828212 1.069872437 0.097438791 0.719130264 1 14.67066572 15.43309391 22933 sirtuin 2 "GO:0000122,GO:0000183,GO:0000781,GO:0000792,GO:0003682,GO:0003950,GO:0004407,GO:0005515,GO:0005634,GO:0005677,GO:0005694,GO:0005730,GO:0005737,GO:0005739,GO:0005813,GO:0005814,GO:0005819,GO:0005829,GO:0005874,GO:0005886,GO:0006342,GO:0006348,GO:0006471,GO:0006476,GO:0006914,GO:0007096,GO:0008134,GO:0008270,GO:0008285,GO:0010507,GO:0010801,GO:0014065,GO:0016575,GO:0017136,GO:0021762,GO:0022011,GO:0030426,GO:0030496,GO:0031641,GO:0032436,GO:0033010,GO:0033270,GO:0033558,GO:0034599,GO:0034979,GO:0034983,GO:0035035,GO:0035729,GO:0042177,GO:0042325,GO:0042826,GO:0042903,GO:0043130,GO:0043161,GO:0043204,GO:0043209,GO:0043219,GO:0043220,GO:0043388,GO:0043491,GO:0044224,GO:0044242,GO:0045087,GO:0045599,GO:0045836,GO:0045843,GO:0045892,GO:0045944,GO:0046970,GO:0048012,GO:0048471,GO:0051301,GO:0051321,GO:0051726,GO:0051775,GO:0051781,GO:0051987,GO:0061428,GO:0061433,GO:0070403,GO:0070446,GO:0070932,GO:0070933,GO:0071219,GO:0071456,GO:0071872,GO:0072686,GO:0072687,GO:0090042,GO:0097386,GO:1900119,GO:1900195,GO:1900226,GO:1900425,GO:2000378,GO:2000777" "negative regulation of transcription by RNA polymerase II|rDNA heterochromatin assembly|chromosome, telomeric region|heterochromatin|chromatin binding|NAD+ ADP-ribosyltransferase activity|histone deacetylase activity|protein binding|nucleus|chromatin silencing complex|chromosome|nucleolus|cytoplasm|mitochondrion|centrosome|centriole|spindle|cytosol|microtubule|plasma membrane|chromatin silencing|chromatin silencing at telomere|protein ADP-ribosylation|protein deacetylation|autophagy|regulation of exit from mitosis|transcription factor binding|zinc ion binding|negative regulation of cell population proliferation|negative regulation of autophagy|negative regulation of peptidyl-threonine phosphorylation|phosphatidylinositol 3-kinase signaling|histone deacetylation|NAD-dependent histone deacetylase activity|substantia nigra development|myelination in peripheral nervous system|growth cone|midbody|regulation of myelination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|paranodal junction|paranode region of axon|protein deacetylase activity|cellular response to oxidative stress|NAD-dependent protein deacetylase activity|peptidyl-lysine deacetylation|histone acetyltransferase binding|cellular response to hepatocyte growth factor stimulus|negative regulation of protein catabolic process|regulation of phosphorylation|histone deacetylase binding|tubulin deacetylase activity|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|perikaryon|myelin sheath|lateral loop|Schmidt-Lanterman incisure|positive regulation of DNA binding|protein kinase B signaling|juxtaparanode region of axon|cellular lipid catabolic process|innate immune response|negative regulation of fat cell differentiation|positive regulation of meiotic nuclear division|negative regulation of striated muscle tissue development|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|NAD-dependent histone deacetylase activity (H4-K16 specific)|hepatocyte growth factor receptor signaling pathway|perinuclear region of cytoplasm|cell division|meiotic cell cycle|regulation of cell cycle|response to redox state|positive regulation of cell division|positive regulation of attachment of spindle microtubules to kinetochore|negative regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to caloric restriction|NAD+ binding|negative regulation of oligodendrocyte progenitor proliferation|histone H3 deacetylation|histone H4 deacetylation|cellular response to molecule of bacterial origin|cellular response to hypoxia|cellular response to epinephrine stimulus|mitotic spindle|meiotic spindle|tubulin deacetylation|glial cell projection|positive regulation of execution phase of apoptosis|positive regulation of oocyte maturation|negative regulation of NLRP3 inflammasome complex assembly|negative regulation of defense response to bacterium|negative regulation of reactive oxygen species metabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia" hsa00760 Nicotinate and nicotinamide metabolism SIRT3 509.2359777 537.8939773 480.577978 0.893443686 -0.162551296 0.553665845 1 6.426329295 5.645486049 23410 sirtuin 3 "GO:0003950,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0006471,GO:0006476,GO:0007005,GO:0007568,GO:0008270,GO:0009060,GO:0016575,GO:0017136,GO:0019899,GO:0032024,GO:0032991,GO:0034979,GO:0034983,GO:0043565,GO:0070373,GO:0070403,GO:1901671,GO:1902553,GO:2000304,GO:2000378" NAD+ ADP-ribosyltransferase activity|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|protein ADP-ribosylation|protein deacetylation|mitochondrion organization|aging|zinc ion binding|aerobic respiration|histone deacetylation|NAD-dependent histone deacetylase activity|enzyme binding|positive regulation of insulin secretion|protein-containing complex|NAD-dependent protein deacetylase activity|peptidyl-lysine deacetylation|sequence-specific DNA binding|negative regulation of ERK1 and ERK2 cascade|NAD+ binding|positive regulation of superoxide dismutase activity|positive regulation of catalase activity|positive regulation of ceramide biosynthetic process|negative regulation of reactive oxygen species metabolic process "hsa00760,hsa05230" Nicotinate and nicotinamide metabolism|Central carbon metabolism in cancer SIRT4 43.47470055 43.69738307 43.25201802 0.98980797 -0.014779436 1 1 0.948372925 0.922999088 23409 sirtuin 4 "GO:0000820,GO:0003950,GO:0005515,GO:0005739,GO:0005743,GO:0005759,GO:0006471,GO:0006541,GO:0006974,GO:0007005,GO:0008270,GO:0010667,GO:0034979,GO:0034983,GO:0046322,GO:0046676,GO:0046889,GO:0047708,GO:0061690,GO:0070403,GO:0071456,GO:0072350,GO:1903217,GO:1904182" regulation of glutamine family amino acid metabolic process|NAD+ ADP-ribosyltransferase activity|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|protein ADP-ribosylation|glutamine metabolic process|cellular response to DNA damage stimulus|mitochondrion organization|zinc ion binding|negative regulation of cardiac muscle cell apoptotic process|NAD-dependent protein deacetylase activity|peptidyl-lysine deacetylation|negative regulation of fatty acid oxidation|negative regulation of insulin secretion|positive regulation of lipid biosynthetic process|biotinidase activity|lipoamidase activity|NAD+ binding|cellular response to hypoxia|tricarboxylic acid metabolic process|negative regulation of protein processing involved in protein targeting to mitochondrion|regulation of pyruvate dehydrogenase activity hsa00760 Nicotinate and nicotinamide metabolism SIRT5 393.2587835 432.8121752 353.7053918 0.817226067 -0.291192872 0.317362004 1 3.237789503 2.601728656 23408 sirtuin 5 "GO:0003950,GO:0005634,GO:0005739,GO:0005758,GO:0005759,GO:0005829,GO:0006471,GO:0006476,GO:0007005,GO:0008270,GO:0010566,GO:0034979,GO:0036046,GO:0036047,GO:0036048,GO:0036049,GO:0036054,GO:0036055,GO:0061697,GO:0061698,GO:0061699,GO:0070403,GO:2000378" NAD+ ADP-ribosyltransferase activity|nucleus|mitochondrion|mitochondrial intermembrane space|mitochondrial matrix|cytosol|protein ADP-ribosylation|protein deacetylation|mitochondrion organization|zinc ion binding|regulation of ketone biosynthetic process|NAD-dependent protein deacetylase activity|protein demalonylation|peptidyl-lysine demalonylation|protein desuccinylation|peptidyl-lysine desuccinylation|protein-malonyllysine demalonylase activity|protein-succinyllysine desuccinylase activity|protein-glutaryllysine deglutarylase activity|protein deglutarylation|peptidyl-lysine deglutarylation|NAD+ binding|negative regulation of reactive oxygen species metabolic process hsa00760 Nicotinate and nicotinamide metabolism SIRT6 317.5809424 300.6796121 334.4822727 1.11242086 0.153702703 0.625204213 1 8.458997507 9.252502257 51548 sirtuin 6 "GO:0000122,GO:0003247,GO:0003714,GO:0003950,GO:0003956,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006471,GO:0006476,GO:0008270,GO:0010569,GO:0017136,GO:0019213,GO:0031667,GO:0031940,GO:0032206,GO:0034979,GO:0046969,GO:0061647,GO:0070403,GO:0070932,GO:0099115,GO:0120162,GO:1901485,GO:1902732,GO:1905549,GO:1905555,GO:1905564,GO:1990619" "negative regulation of transcription by RNA polymerase II|post-embryonic cardiac muscle cell growth involved in heart morphogenesis|transcription corepressor activity|NAD+ ADP-ribosyltransferase activity|NAD(P)+-protein-arginine ADP-ribosyltransferase activity|histone deacetylase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|protein ADP-ribosylation|protein deacetylation|zinc ion binding|regulation of double-strand break repair via homologous recombination|NAD-dependent histone deacetylase activity|deacetylase activity|response to nutrient levels|positive regulation of chromatin silencing at telomere|positive regulation of telomere maintenance|NAD-dependent protein deacetylase activity|NAD-dependent histone deacetylase activity (H3-K9 specific)|histone H3-K9 modification|NAD+ binding|histone H3 deacetylation|chromosome, subtelomeric region|positive regulation of cold-induced thermogenesis|positive regulation of transcription factor catabolic process|positive regulation of chondrocyte proliferation|positive regulation of subtelomeric heterochromatin assembly|positive regulation of blood vessel branching|positive regulation of vascular endothelial cell proliferation|histone H3-K9 deacetylation" "hsa00760,hsa04714,hsa05230" Nicotinate and nicotinamide metabolism|Thermogenesis|Central carbon metabolism in cancer other SIRT7 701.3917126 725.1684762 677.614949 0.934424167 -0.097850508 0.706348104 1 11.18523375 10.2768568 51547 sirtuin 7 "GO:0000122,GO:0000785,GO:0001649,GO:0003682,GO:0003714,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005731,GO:0005737,GO:0006111,GO:0006281,GO:0006282,GO:0006476,GO:0006974,GO:0007072,GO:0007129,GO:0009303,GO:0010529,GO:0010821,GO:0016570,GO:0016607,GO:0019213,GO:0031397,GO:0034979,GO:0035861,GO:0036049,GO:0036055,GO:0045944,GO:0046825,GO:0046872,GO:0061697,GO:0061698,GO:0061699,GO:0062176,GO:0070403,GO:0070932,GO:0070933,GO:0097372,GO:0106230,GO:0106231,GO:1901836,GO:1990258,GO:2000234,GO:2001032" negative regulation of transcription by RNA polymerase II|chromatin|osteoblast differentiation|chromatin binding|transcription corepressor activity|histone deacetylase activity|protein binding|nucleus|nucleoplasm|nucleolus|nucleolus organizer region|cytoplasm|regulation of gluconeogenesis|DNA repair|regulation of DNA repair|protein deacetylation|cellular response to DNA damage stimulus|positive regulation of transcription involved in exit from mitosis|homologous chromosome pairing at meiosis|rRNA transcription|negative regulation of transposition|regulation of mitochondrion organization|histone modification|nuclear speck|deacetylase activity|negative regulation of protein ubiquitination|NAD-dependent protein deacetylase activity|site of double-strand break|peptidyl-lysine desuccinylation|protein-succinyllysine desuccinylase activity|positive regulation of transcription by RNA polymerase II|regulation of protein export from nucleus|metal ion binding|protein-glutaryllysine deglutarylase activity|protein deglutarylation|peptidyl-lysine deglutarylation|R-loop disassembly|NAD+ binding|histone H3 deacetylation|histone H4 deacetylation|NAD-dependent histone deacetylase activity (H3-K18 specific)|protein depropionylation|protein-propionyllysine depropionylase activity|regulation of transcription of nucleolar large rRNA by RNA polymerase I|histone glutamine methylation|positive regulation of rRNA processing|regulation of double-strand break repair via nonhomologous end joining hsa00760 Nicotinate and nicotinamide metabolism SIVA1 548.9062977 481.7116277 616.1009678 1.278982969 0.354997053 0.185055637 1 15.18491685 19.09626172 10572 SIVA1 apoptosis inducing factor "GO:0001618,GO:0005164,GO:0005175,GO:0005515,GO:0005654,GO:0005737,GO:0046718,GO:0046872,GO:0097191" virus receptor activity|tumor necrosis factor receptor binding|CD27 receptor binding|protein binding|nucleoplasm|cytoplasm|viral entry into host cell|metal ion binding|extrinsic apoptotic signaling pathway hsa04115 p53 signaling pathway SIX1 446.8558041 401.5997587 492.1118495 1.225378847 0.293227853 0.297588898 1 5.335484444 6.428585374 6495 SIX homeobox 1 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001223,GO:0001228,GO:0001657,GO:0001658,GO:0001759,GO:0001822,GO:0003151,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005737,GO:0006355,GO:0006357,GO:0006915,GO:0007389,GO:0007519,GO:0007605,GO:0008582,GO:0014842,GO:0014857,GO:0021610,GO:0030855,GO:0030878,GO:0030910,GO:0032880,GO:0034504,GO:0035909,GO:0042472,GO:0042474,GO:0043524,GO:0043565,GO:0045664,GO:0045893,GO:0045944,GO:0048538,GO:0048665,GO:0048699,GO:0048701,GO:0048704,GO:0048741,GO:0048839,GO:0050678,GO:0051451,GO:0060037,GO:0061055,GO:0061197,GO:0061551,GO:0071599,GO:0072075,GO:0072095,GO:0072107,GO:0072172,GO:0072193,GO:0072513,GO:0090103,GO:0090190,GO:0090336,GO:1905243,GO:1990837,GO:2000729,GO:2001014" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|transcription coactivator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|ureteric bud development|branching involved in ureteric bud morphogenesis|organ induction|kidney development|outflow tract morphogenesis|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|apoptotic process|pattern specification process|skeletal muscle tissue development|sensory perception of sound|regulation of synaptic growth at neuromuscular junction|regulation of skeletal muscle satellite cell proliferation|regulation of skeletal muscle cell proliferation|facial nerve morphogenesis|epithelial cell differentiation|thyroid gland development|olfactory placode formation|regulation of protein localization|protein localization to nucleus|aorta morphogenesis|inner ear morphogenesis|middle ear morphogenesis|negative regulation of neuron apoptotic process|sequence-specific DNA binding|regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|thymus development|neuron fate specification|generation of neurons|embryonic cranial skeleton morphogenesis|embryonic skeletal system morphogenesis|skeletal muscle fiber development|inner ear development|regulation of epithelial cell proliferation|myoblast migration|pharyngeal system development|myotome development|fungiform papilla morphogenesis|trigeminal ganglion development|otic vesicle development|metanephric mesenchyme development|regulation of branch elongation involved in ureteric bud branching|positive regulation of ureteric bud formation|mesonephric tubule formation|ureter smooth muscle cell differentiation|positive regulation of secondary heart field cardioblast proliferation|cochlea morphogenesis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of brown fat cell differentiation|cellular response to 3,3',5-triiodo-L-thyronine|sequence-specific double-stranded DNA binding|positive regulation of mesenchymal cell proliferation involved in ureter development|regulation of skeletal muscle cell differentiation" hsa05202 Transcriptional misregulation in cancer Homeobox SIX4 840.8769843 930.1300111 751.6239576 0.808084836 -0.307421334 0.219179392 1 7.938482198 6.3076213 51804 SIX homeobox 4 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0005634,GO:0005667,GO:0005737,GO:0006357,GO:0007519,GO:0008582,GO:0008584,GO:0009653,GO:0030238,GO:0030910,GO:0032880,GO:0034504,GO:0042472,GO:0043066,GO:0043524,GO:0043586,GO:0045214,GO:0045892,GO:0045893,GO:0045944,GO:0046661,GO:0048538,GO:0048699,GO:0048701,GO:0050678,GO:0051451,GO:0060037,GO:0061055,GO:0061197,GO:0061551,GO:0072075,GO:0072095,GO:0072107,GO:0090190,GO:0098528,GO:1902725,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|transcription regulator complex|cytoplasm|regulation of transcription by RNA polymerase II|skeletal muscle tissue development|regulation of synaptic growth at neuromuscular junction|male gonad development|anatomical structure morphogenesis|male sex determination|olfactory placode formation|regulation of protein localization|protein localization to nucleus|inner ear morphogenesis|negative regulation of apoptotic process|negative regulation of neuron apoptotic process|tongue development|sarcomere organization|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|male sex differentiation|thymus development|generation of neurons|embryonic cranial skeleton morphogenesis|regulation of epithelial cell proliferation|myoblast migration|pharyngeal system development|myotome development|fungiform papilla morphogenesis|trigeminal ganglion development|metanephric mesenchyme development|regulation of branch elongation involved in ureteric bud branching|positive regulation of ureteric bud formation|positive regulation of branching involved in ureteric bud morphogenesis|skeletal muscle fiber differentiation|negative regulation of satellite cell differentiation|sequence-specific double-stranded DNA binding" hsa05202 Transcriptional misregulation in cancer SIX5 226.5095147 206.0019488 247.0170807 1.199100699 0.261952819 0.454608535 1 3.287663095 3.876271082 147912 SIX homeobox 5 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0002088,GO:0005515,GO:0005634,GO:0005667,GO:0005737,GO:0006357,GO:0007286,GO:0045892,GO:0045944,GO:1902723" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|lens development in camera-type eye|protein binding|nucleus|transcription regulator complex|cytoplasm|regulation of transcription by RNA polymerase II|spermatid development|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of skeletal muscle satellite cell proliferation" Homeobox SKA1 1135.544284 1146.536099 1124.552469 0.980826046 -0.027930804 0.912254184 1 21.47719352 20.71289002 220134 spindle and kinetochore associated complex subunit 1 "GO:0000278,GO:0000940,GO:0005515,GO:0005829,GO:0005876,GO:0007059,GO:0008017,GO:0015630,GO:0031110,GO:0051301,GO:0072686" mitotic cell cycle|condensed chromosome outer kinetochore|protein binding|cytosol|spindle microtubule|chromosome segregation|microtubule binding|microtubule cytoskeleton|regulation of microtubule polymerization or depolymerization|cell division|mitotic spindle SKA2 1563.093295 1457.61985 1668.56674 1.1447201 0.194994882 0.413596216 1 25.89563661 29.14721599 348235 spindle and kinetochore associated complex subunit 2 "GO:0000278,GO:0000940,GO:0005515,GO:0005829,GO:0005876,GO:0007059,GO:0008017,GO:0031110,GO:0051301" mitotic cell cycle|condensed chromosome outer kinetochore|protein binding|cytosol|spindle microtubule|chromosome segregation|microtubule binding|regulation of microtubule polymerization or depolymerization|cell division SKA3 1410.868348 1561.661238 1260.075458 0.806881434 -0.309571401 0.195978965 1 28.77865679 22.83239246 221150 spindle and kinetochore associated complex subunit 3 "GO:0000278,GO:0000776,GO:0000940,GO:0005515,GO:0005813,GO:0005829,GO:0005876,GO:0007059,GO:0031110,GO:0051301,GO:0072686" mitotic cell cycle|kinetochore|condensed chromosome outer kinetochore|protein binding|centrosome|cytosol|spindle microtubule|chromosome segregation|regulation of microtubule polymerization or depolymerization|cell division|mitotic spindle SKAP1 4.042768641 5.202069413 2.883467868 0.554292463 -0.851280704 0.745112452 1 0.114154969 0.062216413 8631 src kinase associated phosphoprotein 1 "GO:0001772,GO:0001954,GO:0002250,GO:0002821,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0017124,GO:0019901,GO:0019903,GO:0033625,GO:0033634,GO:0034116,GO:0042101,GO:0042169,GO:0044853,GO:0044877,GO:0045893,GO:0045944,GO:0050852,GO:0072659,GO:1903039" "immunological synapse|positive regulation of cell-matrix adhesion|adaptive immune response|positive regulation of adaptive immune response|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|cell-cell junction|SH3 domain binding|protein kinase binding|protein phosphatase binding|positive regulation of integrin activation|positive regulation of cell-cell adhesion mediated by integrin|positive regulation of heterotypic cell-cell adhesion|T cell receptor complex|SH2 domain binding|plasma membrane raft|protein-containing complex binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|T cell receptor signaling pathway|protein localization to plasma membrane|positive regulation of leukocyte cell-cell adhesion" hsa04015 Rap1 signaling pathway SKAP2 1711.556677 1545.014616 1878.098738 1.215586389 0.281652426 0.235625436 1 11.33396432 13.54686642 8935 src kinase associated phosphoprotein 2 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0008285,GO:0042113,GO:0065003" protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|signal transduction|negative regulation of cell population proliferation|B cell activation|protein-containing complex assembly hsa05135 Yersinia infection SKI 1495.514853 1500.276819 1490.752888 0.993651884 -0.009187588 0.972402214 1 7.238677916 7.072365422 6497 SKI proto-oncogene "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0001843,GO:0002089,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005813,GO:0006351,GO:0007179,GO:0008270,GO:0008285,GO:0009948,GO:0010626,GO:0014902,GO:0016604,GO:0016605,GO:0017053,GO:0019901,GO:0019904,GO:0021772,GO:0022011,GO:0030177,GO:0030326,GO:0030509,GO:0030512,GO:0030514,GO:0031064,GO:0031625,GO:0032926,GO:0032991,GO:0035019,GO:0042802,GO:0043010,GO:0043388,GO:0043585,GO:0045668,GO:0045944,GO:0046332,GO:0046811,GO:0048147,GO:0048593,GO:0048741,GO:0048870,GO:0060021,GO:0060041,GO:0060325,GO:0060349,GO:0060395,GO:0070491" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|neural tube closure|lens morphogenesis in camera-type eye|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|centrosome|transcription, DNA-templated|transforming growth factor beta receptor signaling pathway|zinc ion binding|negative regulation of cell population proliferation|anterior/posterior axis specification|negative regulation of Schwann cell proliferation|myotube differentiation|nuclear body|PML body|transcription repressor complex|protein kinase binding|protein domain specific binding|olfactory bulb development|myelination in peripheral nervous system|positive regulation of Wnt signaling pathway|embryonic limb morphogenesis|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of histone deacetylation|ubiquitin protein ligase binding|negative regulation of activin receptor signaling pathway|protein-containing complex|somatic stem cell population maintenance|identical protein binding|camera-type eye development|positive regulation of DNA binding|nose morphogenesis|negative regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|SMAD binding|histone deacetylase inhibitor activity|negative regulation of fibroblast proliferation|camera-type eye morphogenesis|skeletal muscle fiber development|cell motility|roof of mouth development|retina development in camera-type eye|face morphogenesis|bone morphogenesis|SMAD protein signal transduction|repressing transcription factor binding" other SKIDA1 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.011912675 0.016231529 387640 SKI/DACH domain containing 1 SKIL 885.5254625 1042.49471 728.5562146 0.698858428 -0.516927865 0.03769765 0.980067228 7.572618303 5.203630523 6498 SKI like proto-oncogene "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0001669,GO:0001825,GO:0002260,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0007050,GO:0007179,GO:0007283,GO:0030512,GO:0030514,GO:0032991,GO:0034097,GO:0045596,GO:0046332,GO:0050772,GO:0070306,GO:1902043,GO:1902231" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|acrosomal vesicle|blastocyst formation|lymphocyte homeostasis|chromatin binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|cell cycle arrest|transforming growth factor beta receptor signaling pathway|spermatogenesis|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|protein-containing complex|response to cytokine|negative regulation of cell differentiation|SMAD binding|positive regulation of axonogenesis|lens fiber cell differentiation|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage" hsa04550 Signaling pathways regulating pluripotency of stem cells SKIV2L 920.6478983 942.6149777 898.6808189 0.953391194 -0.068859795 0.784665642 1 13.02242529 12.20770959 6499 Ski2 like RNA helicase "GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0006401,GO:0043928,GO:0055087,GO:0070478" "RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|cytosol|RNA catabolic process|exonucleolytic catabolism of deadenylated mRNA|Ski complex|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay" hsa03018 RNA degradation SKOR1 11.93016111 10.40413883 13.45618338 1.29334908 0.371111717 0.792410181 1 0.148541939 0.188901769 390598 SKI family transcriptional corepressor 1 "GO:0000122,GO:0000978,GO:0000981,GO:0005634,GO:0005667,GO:0006355,GO:0030425,GO:0030514,GO:0043025,GO:0046332,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|transcription regulator complex|regulation of transcription, DNA-templated|dendrite|negative regulation of BMP signaling pathway|neuronal cell body|SMAD binding|sequence-specific double-stranded DNA binding" SKP1 3945.553879 3457.295332 4433.812425 1.282451165 0.358903889 0.131807028 1 18.31905258 23.10016192 6500 S-phase kinase associated protein 1 "GO:0000086,GO:0000209,GO:0002223,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006879,GO:0008013,GO:0010265,GO:0010972,GO:0016032,GO:0016055,GO:0016567,GO:0019005,GO:0019904,GO:0031146,GO:0031467,GO:0031519,GO:0035518,GO:0038061,GO:0038095,GO:0043687,GO:0050852,GO:0051403,GO:0051457,GO:0070498,GO:0070936,GO:0097602,GO:1901990,GO:1904668,GO:1990444,GO:1990756" G2/M transition of mitotic cell cycle|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|cellular iron ion homeostasis|beta-catenin binding|SCF complex assembly|negative regulation of G2/M transition of mitotic cell cycle|viral process|Wnt signaling pathway|protein ubiquitination|SCF ubiquitin ligase complex|protein domain specific binding|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|Cul7-RING ubiquitin ligase complex|PcG protein complex|histone H2A monoubiquitination|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|post-translational protein modification|T cell receptor signaling pathway|stress-activated MAPK cascade|maintenance of protein location in nucleus|interleukin-1-mediated signaling pathway|protein K48-linked ubiquitination|cullin family protein binding|regulation of mitotic cell cycle phase transition|positive regulation of ubiquitin protein ligase activity|F-box domain binding|ubiquitin ligase-substrate adaptor activity "hsa04110,hsa04114,hsa04120,hsa04141,hsa04310,hsa04350,hsa04710,hsa05131,hsa05132,hsa05170,hsa05200" Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Wnt signaling pathway|TGF-beta signaling pathway|Circadian rhythm|Shigellosis|Salmonella infection|Human immunodeficiency virus 1 infection|Pathways in cancer SKP2 953.3272008 942.6149777 964.0394239 1.022728735 0.032423541 0.899818556 1 8.338410228 8.385228357 6502 S-phase kinase associated protein 2 "GO:0000082,GO:0000086,GO:0000209,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0016032,GO:0016579,GO:0019005,GO:0031146,GO:0042802,GO:0042981,GO:0043161,GO:0043687,GO:0045087,GO:0051607,GO:0051726,GO:0070936" G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|protein polyubiquitination|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|viral process|protein deubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|identical protein binding|regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|innate immune response|defense response to virus|regulation of cell cycle|protein K48-linked ubiquitination "hsa04068,hsa04110,hsa04120,hsa04150,hsa05169,hsa05200,hsa05203,hsa05222" FoxO signaling pathway|Cell cycle|Ubiquitin mediated proteolysis|mTOR signaling pathway|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Small cell lung cancer SLAIN1 218.4636064 196.6382238 240.288989 1.221985148 0.289226751 0.414475399 1 2.949471782 3.543899126 122060 SLAIN motif family member 1 "GO:0005515,GO:0005737,GO:0005856" protein binding|cytoplasm|cytoskeleton SLAIN2 1926.496493 1939.331477 1913.661508 0.986763496 -0.019223749 0.937587495 1 16.65838671 16.16282211 57606 SLAIN motif family member 2 "GO:0005515,GO:0005813,GO:0005829,GO:0007020,GO:0015630,GO:0031116,GO:0031122,GO:0035371" protein binding|centrosome|cytosol|microtubule nucleation|microtubule cytoskeleton|positive regulation of microtubule polymerization|cytoplasmic microtubule organization|microtubule plus-end SLAMF9 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.052942728 89886 SLAM family member 9 "GO:0003674,GO:0008150,GO:0016021" molecular_function|biological_process|integral component of membrane SLBP 2205.360053 2018.402932 2392.317174 1.185252526 0.245194468 0.299814583 1 59.51295847 69.3575284 7884 stem-loop binding protein "GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006369,GO:0006398,GO:0006406,GO:0008334,GO:0042802,GO:0051028,GO:0071204,GO:0071207,GO:0071208,GO:1990904" RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|termination of RNA polymerase II transcription|mRNA 3'-end processing by stem-loop binding and cleavage|mRNA export from nucleus|histone mRNA metabolic process|identical protein binding|mRNA transport|histone pre-mRNA 3'end processing complex|histone pre-mRNA stem-loop binding|histone pre-mRNA DCP binding|ribonucleoprotein complex SLC10A3 709.7546526 742.8555122 676.653793 0.910882105 -0.134663755 0.601335283 1 12.15726261 10.88852737 8273 solute carrier family 10 member 3 "GO:0008508,GO:0015721,GO:0016021,GO:0055085" bile acid:sodium symporter activity|bile acid and bile salt transport|integral component of membrane|transmembrane transport SLC10A5 2.561405743 4.161655531 0.961155956 0.230955193 -2.11431511 0.482263142 1 0.155532148 0.035319869 347051 solute carrier family 10 member 5 "GO:0006814,GO:0008508,GO:0015721,GO:0016021,GO:0055085" sodium ion transport|bile acid:sodium symporter activity|bile acid and bile salt transport|integral component of membrane|transmembrane transport SLC10A7 267.8933267 270.5076095 265.2790439 0.980671281 -0.028158466 0.943703372 1 1.125564786 1.085338311 84068 solute carrier family 10 member 7 "GO:0000139,GO:0005783,GO:0005789,GO:0005794,GO:0005797,GO:0005801,GO:0005802,GO:0005886,GO:0006814,GO:0006874,GO:0015125,GO:0015293,GO:0015721,GO:0016021,GO:0030210,GO:0031226,GO:0034436,GO:0048193,GO:0055085,GO:0060348" Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|Golgi medial cisterna|cis-Golgi network|trans-Golgi network|plasma membrane|sodium ion transport|cellular calcium ion homeostasis|bile acid transmembrane transporter activity|symporter activity|bile acid and bile salt transport|integral component of membrane|heparin biosynthetic process|intrinsic component of plasma membrane|glycoprotein transport|Golgi vesicle transport|transmembrane transport|bone development SLC11A2 2340.448469 2599.994293 2080.902645 0.800348928 -0.321298986 0.174054773 1 18.35651764 14.44577486 4891 solute carrier family 11 member 2 "GO:0001666,GO:0005375,GO:0005381,GO:0005384,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005741,GO:0005765,GO:0005769,GO:0005773,GO:0005886,GO:0005887,GO:0006783,GO:0006824,GO:0006825,GO:0006826,GO:0006828,GO:0006879,GO:0007611,GO:0009986,GO:0010039,GO:0015086,GO:0015087,GO:0015093,GO:0015094,GO:0015099,GO:0015295,GO:0015692,GO:0016020,GO:0016324,GO:0031410,GO:0031526,GO:0031902,GO:0033212,GO:0034755,GO:0035434,GO:0035444,GO:0045177,GO:0045178,GO:0046870,GO:0046915,GO:0048471,GO:0048813,GO:0048821,GO:0055037,GO:0060586,GO:0070574,GO:0070826,GO:0071421,GO:1902600,GO:1903561" response to hypoxia|copper ion transmembrane transporter activity|iron ion transmembrane transporter activity|manganese ion transmembrane transporter activity|protein binding|nucleus|cytoplasm|mitochondrion|mitochondrial outer membrane|lysosomal membrane|early endosome|vacuole|plasma membrane|integral component of plasma membrane|heme biosynthetic process|cobalt ion transport|copper ion transport|iron ion transport|manganese ion transport|cellular iron ion homeostasis|learning or memory|cell surface|response to iron ion|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|nickel cation transmembrane transporter activity|solute:proton symporter activity|lead ion transport|membrane|apical plasma membrane|cytoplasmic vesicle|brush border membrane|late endosome membrane|iron import into cell|iron ion transmembrane transport|copper ion transmembrane transport|nickel cation transmembrane transport|apical part of cell|basal part of cell|cadmium ion binding|transition metal ion transmembrane transporter activity|perinuclear region of cytoplasm|dendrite morphogenesis|erythrocyte development|recycling endosome|multicellular organismal iron ion homeostasis|cadmium ion transmembrane transport|paraferritin complex|manganese ion transmembrane transport|proton transmembrane transport|extracellular vesicle "hsa04142,hsa04216,hsa04978" Lysosome|Ferroptosis|Mineral absorption SLC12A2 507.997419 530.6110801 485.3837578 0.914763705 -0.128528969 0.641294769 1 2.602972527 2.34126023 6558 solute carrier family 12 member 2 "GO:0005515,GO:0005829,GO:0005886,GO:0005887,GO:0006811,GO:0006883,GO:0006884,GO:0006972,GO:0007214,GO:0007568,GO:0008511,GO:0008519,GO:0009925,GO:0010818,GO:0015079,GO:0015377,GO:0015379,GO:0015696,GO:0016020,GO:0016324,GO:0016328,GO:0019901,GO:0030007,GO:0030321,GO:0030644,GO:0030659,GO:0031253,GO:0035633,GO:0035725,GO:0035865,GO:0042995,GO:0043005,GO:0043025,GO:0044297,GO:0044298,GO:0045795,GO:0046873,GO:0051087,GO:0051879,GO:0055064,GO:0055075,GO:0055078,GO:0061044,GO:0070062,GO:0070634,GO:0071944,GO:0072488,GO:0089717,GO:0098658,GO:0098659,GO:0098719,GO:0150003,GO:0150104,GO:1902476,GO:1903561,GO:1904450,GO:1904464,GO:1990573,GO:1990869" protein binding|cytosol|plasma membrane|integral component of plasma membrane|ion transport|cellular sodium ion homeostasis|cell volume homeostasis|hyperosmotic response|gamma-aminobutyric acid signaling pathway|aging|sodium:potassium:chloride symporter activity|ammonium transmembrane transporter activity|basal plasma membrane|T cell chemotaxis|potassium ion transmembrane transporter activity|cation:chloride symporter activity|potassium:chloride symporter activity|ammonium transport|membrane|apical plasma membrane|lateral plasma membrane|protein kinase binding|cellular potassium ion homeostasis|transepithelial chloride transport|cellular chloride ion homeostasis|cytoplasmic vesicle membrane|cell projection membrane|maintenance of blood-brain barrier|sodium ion transmembrane transport|cellular response to potassium ion|cell projection|neuron projection|neuronal cell body|cell body|cell body membrane|positive regulation of cell volume|metal ion transmembrane transporter activity|chaperone binding|Hsp90 protein binding|chloride ion homeostasis|potassium ion homeostasis|sodium ion homeostasis|negative regulation of vascular wound healing|extracellular exosome|transepithelial ammonium transport|cell periphery|ammonium transmembrane transport|spanning component of membrane|inorganic anion import across plasma membrane|inorganic cation import across plasma membrane|sodium ion import across plasma membrane|regulation of spontaneous synaptic transmission|transport across blood-brain barrier|chloride transmembrane transport|extracellular vesicle|positive regulation of aspartate secretion|regulation of matrix metallopeptidase secretion|potassium ion import across plasma membrane|cellular response to chemokine "hsa04970,hsa04972,hsa05110" Salivary secretion|Pancreatic secretion|Vibrio cholerae infection SLC12A4 1560.224918 1420.16495 1700.284886 1.197244649 0.259717987 0.275813039 1 15.55656675 18.31335187 6560 solute carrier family 12 member 4 "GO:0005515,GO:0005765,GO:0005886,GO:0005887,GO:0006811,GO:0006884,GO:0007268,GO:0008519,GO:0015379,GO:0016020,GO:0019901,GO:0045202,GO:0055064,GO:0055075,GO:0140157,GO:1902476,GO:1990573" protein binding|lysosomal membrane|plasma membrane|integral component of plasma membrane|ion transport|cell volume homeostasis|chemical synaptic transmission|ammonium transmembrane transporter activity|potassium:chloride symporter activity|membrane|protein kinase binding|synapse|chloride ion homeostasis|potassium ion homeostasis|ammonium import across plasma membrane|chloride transmembrane transport|potassium ion import across plasma membrane SLC12A6 1099.555655 1110.121613 1088.989698 0.980964325 -0.027727425 0.913272997 1 6.469223647 6.239884591 9990 solute carrier family 12 member 6 "GO:0001525,GO:0005886,GO:0005887,GO:0006811,GO:0006884,GO:0007268,GO:0008519,GO:0015379,GO:0016021,GO:0016323,GO:0045202,GO:0055064,GO:0055075,GO:0071477,GO:0140157,GO:1902476,GO:1990573" angiogenesis|plasma membrane|integral component of plasma membrane|ion transport|cell volume homeostasis|chemical synaptic transmission|ammonium transmembrane transporter activity|potassium:chloride symporter activity|integral component of membrane|basolateral plasma membrane|synapse|chloride ion homeostasis|potassium ion homeostasis|cellular hypotonic salinity response|ammonium import across plasma membrane|chloride transmembrane transport|potassium ion import across plasma membrane SLC12A7 712.6330901 755.3404788 669.9257013 0.88691884 -0.173126002 0.500105959 1 6.135636697 5.350750432 10723 solute carrier family 12 member 7 "GO:0005886,GO:0005887,GO:0006811,GO:0006884,GO:0007268,GO:0008519,GO:0015379,GO:0019901,GO:0032991,GO:0045202,GO:0055064,GO:0055075,GO:0140157,GO:1902476,GO:1990573" plasma membrane|integral component of plasma membrane|ion transport|cell volume homeostasis|chemical synaptic transmission|ammonium transmembrane transporter activity|potassium:chloride symporter activity|protein kinase binding|protein-containing complex|synapse|chloride ion homeostasis|potassium ion homeostasis|ammonium import across plasma membrane|chloride transmembrane transport|potassium ion import across plasma membrane hsa04966 Collecting duct acid secretion SLC12A8 4.642233509 8.323311061 0.961155956 0.115477596 -3.11431511 0.11677594 1 0.127277884 0.014451797 84561 solute carrier family 12 member 8 "GO:0005515,GO:0006884,GO:0015379,GO:0016021,GO:0055064,GO:0055075,GO:1902476,GO:1990573" protein binding|cell volume homeostasis|potassium:chloride symporter activity|integral component of membrane|chloride ion homeostasis|potassium ion homeostasis|chloride transmembrane transport|potassium ion import across plasma membrane SLC12A9 443.2288324 457.7821084 428.6755564 0.936418328 -0.094774924 0.742490974 1 6.478650161 5.965208293 56996 solute carrier family 12 member 9 "GO:0005886,GO:0006884,GO:0015377,GO:0015379,GO:0016021,GO:0055064,GO:0055075,GO:0070062,GO:1902476,GO:1990573" plasma membrane|cell volume homeostasis|cation:chloride symporter activity|potassium:chloride symporter activity|integral component of membrane|chloride ion homeostasis|potassium ion homeostasis|extracellular exosome|chloride transmembrane transport|potassium ion import across plasma membrane SLC13A3 97.71020059 117.5667687 77.85363244 0.66220781 -0.594644069 0.208116315 1 1.483992992 0.966267399 64849 solute carrier family 13 member 3 "GO:0005310,GO:0005515,GO:0005886,GO:0006814,GO:0006835,GO:0015137,GO:0015139,GO:0015141,GO:0015362,GO:0015742,GO:0015746,GO:0016021,GO:0016323,GO:0017153,GO:0034634,GO:0034775,GO:0070062,GO:0071422,GO:0098656,GO:0150104" dicarboxylic acid transmembrane transporter activity|protein binding|plasma membrane|sodium ion transport|dicarboxylic acid transport|citrate transmembrane transporter activity|alpha-ketoglutarate transmembrane transporter activity|succinate transmembrane transporter activity|high-affinity sodium:dicarboxylate symporter activity|alpha-ketoglutarate transport|citrate transport|integral component of membrane|basolateral plasma membrane|sodium:dicarboxylate symporter activity|glutathione transmembrane transporter activity|glutathione transmembrane transport|extracellular exosome|succinate transmembrane transport|anion transmembrane transport|transport across blood-brain barrier SLC14A1 40.67552102 33.29324424 48.0577978 1.443469956 0.52954108 0.424424027 1 0.319395875 0.453323498 6563 solute carrier family 14 member 1 (Kidd blood group) "GO:0005372,GO:0005886,GO:0005887,GO:0006833,GO:0015265,GO:0015840,GO:0016323,GO:0055085,GO:0071918" water transmembrane transporter activity|plasma membrane|integral component of plasma membrane|water transport|urea channel activity|urea transport|basolateral plasma membrane|transmembrane transport|urea transmembrane transport SLC15A1 43.91564956 42.65696919 45.17432993 1.059014055 0.082721737 0.933838568 1 0.728720885 0.758811876 6564 solute carrier family 15 member 1 "GO:0005427,GO:0005886,GO:0005887,GO:0005903,GO:0006811,GO:0015031,GO:0015333,GO:0016324,GO:0042937,GO:0071916,GO:0089717,GO:0140206,GO:0140207,GO:1902600" proton-dependent oligopeptide secondary active transmembrane transporter activity|plasma membrane|integral component of plasma membrane|brush border|ion transport|protein transport|peptide:proton symporter activity|apical plasma membrane|tripeptide transmembrane transporter activity|dipeptide transmembrane transporter activity|spanning component of membrane|dipeptide import across plasma membrane|tripeptide import across plasma membrane|proton transmembrane transport hsa04974 Protein digestion and absorption SLC15A2 16.53276565 17.687036 15.3784953 0.869478373 -0.201777951 0.890777234 1 0.159770583 0.136592478 6565 solute carrier family 15 member 2 "GO:0005515,GO:0005886,GO:0005887,GO:0006811,GO:0015031,GO:0015333,GO:0015835,GO:0016324,GO:0042908,GO:0042938,GO:0044214,GO:0045087,GO:0070062,GO:0070293,GO:0070424,GO:0071916,GO:0089717,GO:0140206,GO:0150104,GO:1902600,GO:1990961" protein binding|plasma membrane|integral component of plasma membrane|ion transport|protein transport|peptide:proton symporter activity|peptidoglycan transport|apical plasma membrane|xenobiotic transport|dipeptide transport|spanning component of plasma membrane|innate immune response|extracellular exosome|renal absorption|regulation of nucleotide-binding oligomerization domain containing signaling pathway|dipeptide transmembrane transporter activity|spanning component of membrane|dipeptide import across plasma membrane|transport across blood-brain barrier|proton transmembrane transport|xenobiotic detoxification by transmembrane export across the plasma membrane SLC15A3 117.2207833 99.87973273 134.5618338 1.347238625 0.430005406 0.334964537 1 2.165947893 2.86921907 51296 solute carrier family 15 member 3 "GO:0005515,GO:0005765,GO:0006811,GO:0010008,GO:0015031,GO:0015293,GO:0015647,GO:0015835,GO:0016021,GO:0043231,GO:0045087,GO:0070434,GO:0071916,GO:0140206" protein binding|lysosomal membrane|ion transport|endosome membrane|protein transport|symporter activity|peptidoglycan transmembrane transporter activity|peptidoglycan transport|integral component of membrane|intracellular membrane-bounded organelle|innate immune response|positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|dipeptide transmembrane transporter activity|dipeptide import across plasma membrane SLC15A4 934.0304685 827.1290367 1040.9319 1.258487919 0.331691368 0.180144991 1 11.44770656 14.16572211 121260 solute carrier family 15 member 4 "GO:0005290,GO:0005515,GO:0005765,GO:0005886,GO:0006811,GO:0015031,GO:0015333,GO:0015647,GO:0015817,GO:0015835,GO:0031303,GO:0031901,GO:0033023,GO:0034157,GO:0034161,GO:0034165,GO:0035579,GO:0036020,GO:0043312,GO:0045087,GO:0045089,GO:0048302,GO:0070424,GO:0070430,GO:0070434,GO:0071916,GO:0089708,GO:0140206,GO:1902600,GO:1905103" L-histidine transmembrane transporter activity|protein binding|lysosomal membrane|plasma membrane|ion transport|protein transport|peptide:proton symporter activity|peptidoglycan transmembrane transporter activity|histidine transport|peptidoglycan transport|integral component of endosome membrane|early endosome membrane|mast cell homeostasis|positive regulation of toll-like receptor 7 signaling pathway|positive regulation of toll-like receptor 8 signaling pathway|positive regulation of toll-like receptor 9 signaling pathway|specific granule membrane|endolysosome membrane|neutrophil degranulation|innate immune response|positive regulation of innate immune response|regulation of isotype switching to IgG isotypes|regulation of nucleotide-binding oligomerization domain containing signaling pathway|positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway|positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|dipeptide transmembrane transporter activity|L-histidine transmembrane export from vacuole|dipeptide import across plasma membrane|proton transmembrane transport|integral component of lysosomal membrane SLC16A1 3139.718959 3421.92126 2857.516657 0.835062072 -0.260044655 0.272340788 1 40.47465612 33.23327221 6566 solute carrier family 16 member 1 "GO:0005515,GO:0005813,GO:0005886,GO:0005887,GO:0006090,GO:0006629,GO:0007098,GO:0008028,GO:0009925,GO:0015129,GO:0015130,GO:0015293,GO:0015718,GO:0015728,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0016328,GO:0030054,GO:0032094,GO:0035879,GO:0042593,GO:0042802,GO:0043231,GO:0045202,GO:0046943,GO:0050796,GO:0050900,GO:0051780,GO:0070062,GO:0071407,GO:0097159,GO:0150104,GO:1905039" protein binding|centrosome|plasma membrane|integral component of plasma membrane|pyruvate metabolic process|lipid metabolic process|centrosome cycle|monocarboxylic acid transmembrane transporter activity|basal plasma membrane|lactate transmembrane transporter activity|mevalonate transmembrane transporter activity|symporter activity|monocarboxylic acid transport|mevalonate transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|cell junction|response to food|plasma membrane lactate transport|glucose homeostasis|identical protein binding|intracellular membrane-bounded organelle|synapse|carboxylic acid transmembrane transporter activity|regulation of insulin secretion|leukocyte migration|behavioral response to nutrient|extracellular exosome|cellular response to organic cyclic compound|organic cyclic compound binding|transport across blood-brain barrier|carboxylic acid transmembrane transport SLC16A10 40.74974853 47.8590386 33.64045846 0.702907109 -0.508594049 0.442453998 1 0.27390337 0.18930692 117247 solute carrier family 16 member 10 "GO:0003333,GO:0005515,GO:0005886,GO:0005887,GO:0006590,GO:0006865,GO:0015171,GO:0015173,GO:0015349,GO:0015801,GO:0016021,GO:0016323,GO:0030054,GO:0043231,GO:0070327,GO:0070460" amino acid transmembrane transport|protein binding|plasma membrane|integral component of plasma membrane|thyroid hormone generation|amino acid transport|amino acid transmembrane transporter activity|aromatic amino acid transmembrane transporter activity|thyroid hormone transmembrane transporter activity|aromatic amino acid transport|integral component of membrane|basolateral plasma membrane|cell junction|intracellular membrane-bounded organelle|thyroid hormone transport|thyroid-stimulating hormone secretion "hsa04919,hsa04974" Thyroid hormone signaling pathway|Protein digestion and absorption SLC16A12 51.52563928 40.57614142 62.47513714 1.539701286 0.622650484 0.298676874 1 0.275330463 0.416832829 387700 solute carrier family 16 member 12 "GO:0005308,GO:0005515,GO:0005886,GO:0005887,GO:0008028,GO:0015293,GO:0015718,GO:0015881,GO:0016021,GO:0016323,GO:0150104" creatine transmembrane transporter activity|protein binding|plasma membrane|integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport|creatine transmembrane transport|integral component of membrane|basolateral plasma membrane|transport across blood-brain barrier SLC16A13 97.55168473 113.4051132 81.69825626 0.720410694 -0.473108499 0.319062791 1 3.3548905 2.37645546 201232 solute carrier family 16 member 13 "GO:0000139,GO:0005515,GO:0005794,GO:0005829,GO:0005887,GO:0008028,GO:0015293,GO:0015718,GO:0016021,GO:0055085" Golgi membrane|protein binding|Golgi apparatus|cytosol|integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport|integral component of membrane|transmembrane transport SLC16A14 123.9287533 149.8195991 98.03790751 0.654373047 -0.611814769 0.158815986 1 1.537319102 0.989146468 151473 solute carrier family 16 member 14 "GO:0005887,GO:0008028,GO:0015293,GO:0015718,GO:0016021,GO:0055085" integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport|integral component of membrane|transmembrane transport SLC16A2 1474.885213 1412.882053 1536.888374 1.087768346 0.121371349 0.612813904 1 18.26621085 19.53691836 6567 solute carrier family 16 member 2 "GO:0005215,GO:0005886,GO:0005887,GO:0006520,GO:0008028,GO:0015171,GO:0015293,GO:0015349,GO:0015718,GO:0016021,GO:0016324,GO:0042403,GO:0043252,GO:0070327,GO:0089718,GO:0150104,GO:2000178" transporter activity|plasma membrane|integral component of plasma membrane|cellular amino acid metabolic process|monocarboxylic acid transmembrane transporter activity|amino acid transmembrane transporter activity|symporter activity|thyroid hormone transmembrane transporter activity|monocarboxylic acid transport|integral component of membrane|apical plasma membrane|thyroid hormone metabolic process|sodium-independent organic anion transport|thyroid hormone transport|amino acid import across plasma membrane|transport across blood-brain barrier|negative regulation of neural precursor cell proliferation hsa04919 Thyroid hormone signaling pathway SLC16A3 5497.425303 4935.723459 6059.127147 1.227606692 0.295848415 0.219883168 1 81.62704975 98.52910225 9123 solute carrier family 16 member 3 "GO:0003723,GO:0005515,GO:0005886,GO:0005887,GO:0006090,GO:0008028,GO:0015129,GO:0015293,GO:0015718,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0016328,GO:0031965,GO:0035879,GO:0050900,GO:0098688,GO:0099061" RNA binding|protein binding|plasma membrane|integral component of plasma membrane|pyruvate metabolic process|monocarboxylic acid transmembrane transporter activity|lactate transmembrane transporter activity|symporter activity|monocarboxylic acid transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|nuclear membrane|plasma membrane lactate transport|leukocyte migration|parallel fiber to Purkinje cell synapse|integral component of postsynaptic density membrane hsa05230 Central carbon metabolism in cancer SLC16A4 5.885822626 3.121241648 8.650403604 2.771462315 1.470647391 0.36367629 1 0.061740152 0.168247202 9122 solute carrier family 16 member 4 "GO:0005887,GO:0008028,GO:0015293,GO:0015718,GO:0016020,GO:0016021,GO:0055085" integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport|membrane|integral component of membrane|transmembrane transport SLC16A5 767.948633 832.3311061 703.5661598 0.845296006 -0.242471461 0.338430005 1 18.8860465 15.69715875 9121 solute carrier family 16 member 5 "GO:0005515,GO:0005887,GO:0008028,GO:0015293,GO:0015718,GO:0016020,GO:0016021,GO:0055085" protein binding|integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport|membrane|integral component of membrane|transmembrane transport SLC16A6 170.5045738 249.6993318 91.30981582 0.365679055 -1.451350097 0.000218433 0.062280513 3.007446268 1.081357114 9120 solute carrier family 16 member 6 "GO:0005515,GO:0005887,GO:0008028,GO:0015293,GO:0015718,GO:0016020,GO:0016021,GO:0055085" protein binding|integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport|membrane|integral component of membrane|transmembrane transport SLC16A7 535.1821581 550.3789439 519.9853722 0.944777009 -0.081954238 0.766354511 1 2.017633788 1.874316104 9194 solute carrier family 16 member 7 "GO:0005477,GO:0005515,GO:0005654,GO:0005886,GO:0005887,GO:0008028,GO:0015129,GO:0015293,GO:0015718,GO:0016021,GO:0035873,GO:0050833,GO:0150104,GO:1901475" pyruvate secondary active transmembrane transporter activity|protein binding|nucleoplasm|plasma membrane|integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|lactate transmembrane transporter activity|symporter activity|monocarboxylic acid transport|integral component of membrane|lactate transmembrane transport|pyruvate transmembrane transporter activity|transport across blood-brain barrier|pyruvate transmembrane transport SLC16A9 37.54421854 52.02069413 23.06774294 0.44343397 -1.173208799 0.079270426 1 0.636316488 0.277442708 220963 solute carrier family 16 member 9 "GO:0005515,GO:0005887,GO:0008028,GO:0015293,GO:0015718,GO:0016021,GO:0046415,GO:0055085" protein binding|integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport|integral component of membrane|urate metabolic process|transmembrane transport SLC17A5 658.2296277 601.3592242 715.1000313 1.18913954 0.249918019 0.335009281 1 9.408805788 11.00116055 26503 solute carrier family 17 member 5 "GO:0005351,GO:0005764,GO:0005765,GO:0005829,GO:0005886,GO:0005887,GO:0006811,GO:0006820,GO:0006865,GO:0009617,GO:0015136,GO:0015538,GO:0015739,GO:0016020,GO:0016021,GO:0022857,GO:0030672,GO:0034219,GO:1902600" carbohydrate:proton symporter activity|lysosome|lysosomal membrane|cytosol|plasma membrane|integral component of plasma membrane|ion transport|anion transport|amino acid transport|response to bacterium|sialic acid transmembrane transporter activity|sialic acid:proton symporter activity|sialic acid transport|membrane|integral component of membrane|transmembrane transporter activity|synaptic vesicle membrane|carbohydrate transmembrane transport|proton transmembrane transport hsa04142 Lysosome SLC17A7 36.10751502 39.53572754 32.6793025 0.82657648 -0.274779782 0.713419355 1 0.715479524 0.581502292 57030 solute carrier family 17 member 7 "GO:0003407,GO:0005313,GO:0005326,GO:0005436,GO:0005886,GO:0006811,GO:0006817,GO:0006820,GO:0007420,GO:0014047,GO:0015319,GO:0015813,GO:0016021,GO:0022857,GO:0030285,GO:0030672,GO:0035249,GO:0035725,GO:0043005,GO:0043229,GO:0048786,GO:0050803,GO:0060076,GO:0060203,GO:0098700,GO:1900242" "neural retina development|L-glutamate transmembrane transporter activity|neurotransmitter transmembrane transporter activity|sodium:phosphate symporter activity|plasma membrane|ion transport|phosphate ion transport|anion transport|brain development|glutamate secretion|sodium:inorganic phosphate symporter activity|L-glutamate transmembrane transport|integral component of membrane|transmembrane transporter activity|integral component of synaptic vesicle membrane|synaptic vesicle membrane|synaptic transmission, glutamatergic|sodium ion transmembrane transport|neuron projection|intracellular organelle|presynaptic active zone|regulation of synapse structure or activity|excitatory synapse|clathrin-sculpted glutamate transport vesicle membrane|neurotransmitter loading into synaptic vesicle|regulation of synaptic vesicle endocytosis" "hsa04721,hsa04723,hsa04724,hsa05033" Synaptic vesicle cycle|Retrograde endocannabinoid signaling|Glutamatergic synapse|Nicotine addiction SLC17A9 299.0862359 281.9521622 316.2203095 1.12153887 0.165479622 0.605313867 1 5.864095359 6.466756862 63910 solute carrier family 17 member 9 "GO:0001409,GO:0005347,GO:0005515,GO:0006887,GO:0015217,GO:0015866,GO:0015867,GO:0016021,GO:0042584,GO:1903790,GO:1904669" guanine nucleotide transmembrane transporter activity|ATP transmembrane transporter activity|protein binding|exocytosis|ADP transmembrane transporter activity|ADP transport|ATP transport|integral component of membrane|chromaffin granule membrane|guanine nucleotide transmembrane transport|ATP export SLC18B1 192.1507045 199.7594655 184.5419436 0.923820772 -0.11431511 0.768172757 1 3.920851611 3.561552149 116843 solute carrier family 18 member B1 "GO:0016021,GO:0022857,GO:0055085" integral component of membrane|transmembrane transporter activity|transmembrane transport SLC19A1 252.470172 281.9521622 222.9881818 0.790872395 -0.338483156 0.312164587 1 1.845158638 1.434865872 6573 solute carrier family 19 member 1 "GO:0005542,GO:0005886,GO:0005887,GO:0007565,GO:0008514,GO:0008517,GO:0008518,GO:0015350,GO:0015711,GO:0015884,GO:0016323,GO:0016324,GO:0031526,GO:0046655,GO:0051958,GO:0055085,GO:0061507,GO:0098838,GO:0140360,GO:0140361,GO:0150104,GO:1904447" folic acid binding|plasma membrane|integral component of plasma membrane|female pregnancy|organic anion transmembrane transporter activity|folic acid transmembrane transporter activity|folate:anion antiporter activity|methotrexate transmembrane transporter activity|organic anion transport|folic acid transport|basolateral plasma membrane|apical plasma membrane|brush border membrane|folic acid metabolic process|methotrexate transport|transmembrane transport|cyclic-GMP-AMP binding|folate transmembrane transport|cyclic-GMP-AMP transmembrane transporter activity|cyclic-GMP-AMP transmembrane import across plasma membrane|transport across blood-brain barrier|folate import across plasma membrane "hsa01523,hsa04977" Antifolate resistance|Vitamin digestion and absorption SLC19A2 287.4183862 316.2858203 258.5509522 0.817459828 -0.290780261 0.365803146 1 4.673198483 3.756226956 10560 solute carrier family 19 member 2 "GO:0005515,GO:0005886,GO:0008517,GO:0015234,GO:0015884,GO:0015888,GO:0016021,GO:0042723,GO:0055085,GO:0071934" protein binding|plasma membrane|folic acid transmembrane transporter activity|thiamine transmembrane transporter activity|folic acid transport|thiamine transport|integral component of membrane|thiamine-containing compound metabolic process|transmembrane transport|thiamine transmembrane transport hsa04977 Vitamin digestion and absorption SLC19A3 12.76739975 19.76786377 5.766935736 0.291732875 -1.777280123 0.091403032 1 0.167695844 0.048103741 80704 solute carrier family 19 member 3 "GO:0005515,GO:0005886,GO:0015234,GO:0016021,GO:0042723,GO:0055085,GO:0071934" protein binding|plasma membrane|thiamine transmembrane transporter activity|integral component of membrane|thiamine-containing compound metabolic process|transmembrane transport|thiamine transmembrane transport hsa04977 Vitamin digestion and absorption SLC1A1 86.22601891 93.63724944 78.81478839 0.84170337 -0.248616202 0.627535569 1 1.039793571 0.860552504 6505 solute carrier family 1 member 1 "GO:0001662,GO:0001932,GO:0005313,GO:0005314,GO:0005515,GO:0005783,GO:0005886,GO:0005887,GO:0006749,GO:0006811,GO:0006882,GO:0006919,GO:0007268,GO:0007611,GO:0009986,GO:0010460,GO:0010842,GO:0014047,GO:0015108,GO:0015183,GO:0015501,GO:0015813,GO:0016020,GO:0016021,GO:0016324,GO:0016595,GO:0018105,GO:0030424,GO:0030425,GO:0031901,GO:0031902,GO:0032279,GO:0033229,GO:0035633,GO:0036293,GO:0036475,GO:0042802,GO:0042883,GO:0043025,GO:0043083,GO:0043197,GO:0043198,GO:0043204,GO:0043679,GO:0046872,GO:0048514,GO:0048678,GO:0051938,GO:0055038,GO:0060013,GO:0060047,GO:0060291,GO:0070062,GO:0070633,GO:0070777,GO:0070778,GO:0070779,GO:0071242,GO:0071944,GO:0072347,GO:0090313,GO:0090461,GO:0097049,GO:0097386,GO:0097440,GO:0098712,GO:0098793,GO:0098877,GO:0099544,GO:0140009,GO:0140010,GO:0150002,GO:0150104,GO:1902476,GO:1903712,GO:1990635" behavioral fear response|regulation of protein phosphorylation|L-glutamate transmembrane transporter activity|high-affinity glutamate transmembrane transporter activity|protein binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|glutathione metabolic process|ion transport|cellular zinc ion homeostasis|activation of cysteine-type endopeptidase activity involved in apoptotic process|chemical synaptic transmission|learning or memory|cell surface|positive regulation of heart rate|retina layer formation|glutamate secretion|chloride transmembrane transporter activity|L-aspartate transmembrane transporter activity|glutamate:sodium symporter activity|L-glutamate transmembrane transport|membrane|integral component of membrane|apical plasma membrane|glutamate binding|peptidyl-serine phosphorylation|axon|dendrite|early endosome membrane|late endosome membrane|asymmetric synapse|cysteine transmembrane transporter activity|maintenance of blood-brain barrier|response to decreased oxygen levels|neuron death in response to oxidative stress|identical protein binding|cysteine transport|neuronal cell body|synaptic cleft|dendritic spine|dendritic shaft|perikaryon|axon terminus|metal ion binding|blood vessel morphogenesis|response to axon injury|L-glutamate import|recycling endosome membrane|righting reflex|heart contraction|long-term synaptic potentiation|extracellular exosome|transepithelial transport|D-aspartate transport|L-aspartate transmembrane transport|D-aspartate import across plasma membrane|cellular response to ammonium ion|cell periphery|response to anesthetic|regulation of protein targeting to membrane|glutamate homeostasis|motor neuron apoptotic process|glial cell projection|apical dendrite|L-glutamate import across plasma membrane|presynapse|neurotransmitter receptor transport to plasma membrane|perisynaptic space|L-aspartate import across plasma membrane|D-aspartate transmembrane transporter activity|distal dendrite|transport across blood-brain barrier|chloride transmembrane transport|cysteine transmembrane transport|proximal dendrite "hsa04721,hsa04724,hsa04974" Synaptic vesicle cycle|Glutamatergic synapse|Protein digestion and absorption SLC1A3 16.40884834 27.05076095 5.766935736 0.213189409 -2.229792327 0.021136776 0.821508434 0.386726331 0.081066337 6507 solute carrier family 1 member 3 "GO:0001504,GO:0005313,GO:0005314,GO:0005515,GO:0005886,GO:0005887,GO:0006811,GO:0007268,GO:0009925,GO:0014047,GO:0015501,GO:0015813,GO:0016020,GO:0031410,GO:0043005,GO:0043025,GO:0045202,GO:0046872,GO:0048471,GO:0051938,GO:0070633,GO:0070779,GO:0071805,GO:0098712,GO:0098796,GO:0140009,GO:0150104,GO:1902476" neurotransmitter uptake|L-glutamate transmembrane transporter activity|high-affinity glutamate transmembrane transporter activity|protein binding|plasma membrane|integral component of plasma membrane|ion transport|chemical synaptic transmission|basal plasma membrane|glutamate secretion|glutamate:sodium symporter activity|L-glutamate transmembrane transport|membrane|cytoplasmic vesicle|neuron projection|neuronal cell body|synapse|metal ion binding|perinuclear region of cytoplasm|L-glutamate import|transepithelial transport|D-aspartate import across plasma membrane|potassium ion transmembrane transport|L-glutamate import across plasma membrane|membrane protein complex|L-aspartate import across plasma membrane|transport across blood-brain barrier|chloride transmembrane transport "hsa04721,hsa04724,hsa05016" Synaptic vesicle cycle|Glutamatergic synapse|Huntington disease SLC1A4 205.155878 225.7698125 184.5419436 0.817389807 -0.290903842 0.422669269 1 2.597309754 2.087488746 6509 solute carrier family 1 member 4 "GO:0005254,GO:0005813,GO:0005882,GO:0005886,GO:0005887,GO:0006865,GO:0006868,GO:0009986,GO:0015171,GO:0015180,GO:0015183,GO:0015184,GO:0015186,GO:0015193,GO:0015194,GO:0015195,GO:0015293,GO:0015808,GO:0015811,GO:0015824,GO:0015825,GO:0015826,GO:0016020,GO:0016021,GO:0030425,GO:0034589,GO:0034590,GO:0035249,GO:0035524,GO:0042470,GO:0043025,GO:0045202,GO:0050890,GO:0070062,GO:0140009,GO:0150104,GO:1902476,GO:1903812,GO:1904273" "chloride channel activity|centrosome|intermediate filament|plasma membrane|integral component of plasma membrane|amino acid transport|glutamine transport|cell surface|amino acid transmembrane transporter activity|L-alanine transmembrane transporter activity|L-aspartate transmembrane transporter activity|L-cystine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|symporter activity|L-alanine transport|L-cystine transport|proline transport|L-serine transport|threonine transport|membrane|integral component of membrane|dendrite|hydroxyproline transport|L-hydroxyproline transmembrane transporter activity|synaptic transmission, glutamatergic|proline transmembrane transport|melanosome|neuronal cell body|synapse|cognition|extracellular exosome|L-aspartate import across plasma membrane|transport across blood-brain barrier|chloride transmembrane transport|L-serine import across plasma membrane|L-alanine import across plasma membrane" SLC1A5 2239.304411 2556.29691 1922.311912 0.75199086 -0.411212968 0.082024153 1 43.21345195 31.95234233 6510 solute carrier family 1 member 5 "GO:0001618,GO:0005515,GO:0005886,GO:0005887,GO:0006865,GO:0006868,GO:0009925,GO:0010585,GO:0015171,GO:0015175,GO:0015183,GO:0015186,GO:0015194,GO:0015293,GO:0015804,GO:0015825,GO:0016020,GO:0016021,GO:0038023,GO:0042470,GO:0046718,GO:0046872,GO:0070062,GO:0070207,GO:0140009,GO:0150104,GO:1903803" virus receptor activity|protein binding|plasma membrane|integral component of plasma membrane|amino acid transport|glutamine transport|basal plasma membrane|glutamine secretion|amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-aspartate transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-serine transmembrane transporter activity|symporter activity|neutral amino acid transport|L-serine transport|membrane|integral component of membrane|signaling receptor activity|melanosome|viral entry into host cell|metal ion binding|extracellular exosome|protein homotrimerization|L-aspartate import across plasma membrane|transport across blood-brain barrier|L-glutamine import across plasma membrane "hsa04974,hsa05230" Protein digestion and absorption|Central carbon metabolism in cancer SLC20A1 2870.811599 2885.067697 2856.555501 0.990117322 -0.01432861 0.953283121 1 45.37894502 44.17862878 6574 solute carrier family 20 member 1 "GO:0005315,GO:0005316,GO:0005436,GO:0005886,GO:0005887,GO:0006796,GO:0006811,GO:0016020,GO:0016032,GO:0031214,GO:0035435,GO:0035725,GO:0038023,GO:0043123" inorganic phosphate transmembrane transporter activity|high-affinity inorganic phosphate:sodium symporter activity|sodium:phosphate symporter activity|plasma membrane|integral component of plasma membrane|phosphate-containing compound metabolic process|ion transport|membrane|viral process|biomineral tissue development|phosphate ion transmembrane transport|sodium ion transmembrane transport|signaling receptor activity|positive regulation of I-kappaB kinase/NF-kappaB signaling SLC20A2 307.8008061 321.4878897 294.1137225 0.914851638 -0.128390295 0.687961108 1 2.137971066 1.923196554 6575 solute carrier family 20 member 2 "GO:0001618,GO:0005315,GO:0005436,GO:0005886,GO:0005887,GO:0006811,GO:0016020,GO:0035435,GO:0035725,GO:0038023,GO:0046718,GO:0070062" virus receptor activity|inorganic phosphate transmembrane transporter activity|sodium:phosphate symporter activity|plasma membrane|integral component of plasma membrane|ion transport|membrane|phosphate ion transmembrane transport|sodium ion transmembrane transport|signaling receptor activity|viral entry into host cell|extracellular exosome SLC22A1 5.16244045 9.363724944 0.961155956 0.102646752 -3.284240111 0.082212168 1 0.110412017 0.011143785 6580 solute carrier family 22 member 1 "GO:0005277,GO:0005326,GO:0005330,GO:0005334,GO:0005515,GO:0005886,GO:0005887,GO:0006836,GO:0006855,GO:0008504,GO:0008513,GO:0010248,GO:0015101,GO:0015214,GO:0015651,GO:0015695,GO:0015697,GO:0015874,GO:0016020,GO:0016323,GO:0016324,GO:0019534,GO:0042802,GO:0042908,GO:0042910,GO:0048241,GO:0051610,GO:0051620,GO:0072531,GO:0090494,GO:0098655,GO:0098793,GO:0150104,GO:1901374,GO:1901998,GO:1990962" acetylcholine transmembrane transporter activity|neurotransmitter transmembrane transporter activity|dopamine:sodium symporter activity|norepinephrine:sodium symporter activity|protein binding|plasma membrane|integral component of plasma membrane|neurotransmitter transport|drug transmembrane transport|monoamine transmembrane transporter activity|secondary active organic cation transmembrane transporter activity|establishment or maintenance of transmembrane electrochemical gradient|organic cation transmembrane transporter activity|pyrimidine nucleoside transmembrane transporter activity|quaternary ammonium group transmembrane transporter activity|organic cation transport|quaternary ammonium group transport|norepinephrine transport|membrane|basolateral plasma membrane|apical plasma membrane|toxin transmembrane transporter activity|identical protein binding|xenobiotic transport|xenobiotic transmembrane transporter activity|epinephrine transport|serotonin uptake|norepinephrine uptake|pyrimidine-containing compound transmembrane transport|dopamine uptake|cation transmembrane transport|presynapse|transport across blood-brain barrier|acetate ester transport|toxin transport|xenobiotic transport across blood-brain barrier "hsa04976,hsa05231" Bile secretion|Choline metabolism in cancer SLC22A13 4.845408743 1.040413883 8.650403604 8.314386946 3.055609892 0.118982446 1 0.018526852 0.151461779 9390 solute carrier family 22 member 13 "GO:0002854,GO:0005783,GO:0005794,GO:0005886,GO:0015747,GO:0016021,GO:0016324,GO:0034356,GO:0045922,GO:0055085,GO:0070062,GO:0090416,GO:2001142" positive regulation of T cell mediated cytotoxicity directed against tumor cell target|endoplasmic reticulum|Golgi apparatus|plasma membrane|urate transport|integral component of membrane|apical plasma membrane|NAD biosynthesis via nicotinamide riboside salvage pathway|negative regulation of fatty acid metabolic process|transmembrane transport|extracellular exosome|nicotinate transmembrane transporter activity|nicotinate transport SLC22A14 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.055636249 0.016845949 9389 solute carrier family 22 member 14 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021,GO:0022857,GO:0055085" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane|transmembrane transporter activity|transmembrane transport SLC22A15 774.9597722 726.2088901 823.7106543 1.13426132 0.181753058 0.473643151 1 4.793029155 5.345574315 55356 solute carrier family 22 member 15 "GO:0003674,GO:0005575,GO:0006811,GO:0008150,GO:0016021,GO:0022857,GO:0055085" molecular_function|cellular_component|ion transport|biological_process|integral component of membrane|transmembrane transporter activity|transmembrane transport SLC22A17 23.26085734 17.687036 28.83467868 1.63027195 0.705112644 0.393311735 1 0.386854346 0.62012425 51310 solute carrier family 22 member 17 "GO:0004888,GO:0005515,GO:0005774,GO:0005886,GO:0005887,GO:0006879,GO:0015891,GO:0022857,GO:0031301,GO:0055085" transmembrane signaling receptor activity|protein binding|vacuolar membrane|plasma membrane|integral component of plasma membrane|cellular iron ion homeostasis|siderophore transport|transmembrane transporter activity|integral component of organelle membrane|transmembrane transport SLC22A18 638.0749208 627.3695712 648.7802703 1.03412773 0.04841439 0.858058937 1 14.35744467 14.59897999 5002 solute carrier family 22 member 18 "GO:0005515,GO:0005635,GO:0005737,GO:0005886,GO:0007588,GO:0015293,GO:0015695,GO:0016020,GO:0016021,GO:0016324,GO:0022857,GO:0031625,GO:0042908,GO:1990961" protein binding|nuclear envelope|cytoplasm|plasma membrane|excretion|symporter activity|organic cation transport|membrane|integral component of membrane|apical plasma membrane|transmembrane transporter activity|ubiquitin protein ligase binding|xenobiotic transport|xenobiotic detoxification by transmembrane export across the plasma membrane SLC22A23 108.06968 149.8195991 66.31976096 0.44266412 -1.175715655 0.01021997 0.610531935 0.790625595 0.344125115 63027 solute carrier family 22 member 23 "GO:0005515,GO:0006811,GO:0016021,GO:0022857,GO:0055085" protein binding|ion transport|integral component of membrane|transmembrane transporter activity|transmembrane transport SLC22A3 4.483717655 4.161655531 4.80577978 1.154775965 0.207612985 1 1 0.015219619 0.017281153 6581 solute carrier family 22 member 3 "GO:0001692,GO:0005326,GO:0005330,GO:0005515,GO:0005886,GO:0005887,GO:0006836,GO:0006855,GO:0008504,GO:0008514,GO:0015101,GO:0015651,GO:0015695,GO:0015697,GO:0015711,GO:0015718,GO:0015844,GO:0016020,GO:0019534,GO:0032098,GO:0042908,GO:0043025,GO:0051610,GO:0051615,GO:0051620,GO:0051625,GO:0090494,GO:0098793,GO:0150104,GO:1901998" histamine metabolic process|neurotransmitter transmembrane transporter activity|dopamine:sodium symporter activity|protein binding|plasma membrane|integral component of plasma membrane|neurotransmitter transport|drug transmembrane transport|monoamine transmembrane transporter activity|organic anion transmembrane transporter activity|organic cation transmembrane transporter activity|quaternary ammonium group transmembrane transporter activity|organic cation transport|quaternary ammonium group transport|organic anion transport|monocarboxylic acid transport|monoamine transport|membrane|toxin transmembrane transporter activity|regulation of appetite|xenobiotic transport|neuronal cell body|serotonin uptake|histamine uptake|norepinephrine uptake|epinephrine uptake|dopamine uptake|presynapse|transport across blood-brain barrier|toxin transport hsa05231 Choline metabolism in cancer SLC22A4 261.4822667 278.8309205 244.1336128 0.875561478 -0.191719614 0.566875723 1 5.204859657 4.480916467 6583 solute carrier family 22 member 4 "GO:0000166,GO:0005515,GO:0005524,GO:0005739,GO:0005886,GO:0005887,GO:0006641,GO:0006814,GO:0007589,GO:0008513,GO:0009437,GO:0015171,GO:0015226,GO:0015293,GO:0015491,GO:0015651,GO:0015695,GO:0015697,GO:0015879,GO:0016324,GO:0030165,GO:0042908,GO:0089718,GO:1902603" nucleotide binding|protein binding|ATP binding|mitochondrion|plasma membrane|integral component of plasma membrane|triglyceride metabolic process|sodium ion transport|body fluid secretion|secondary active organic cation transmembrane transporter activity|carnitine metabolic process|amino acid transmembrane transporter activity|carnitine transmembrane transporter activity|symporter activity|cation:cation antiporter activity|quaternary ammonium group transmembrane transporter activity|organic cation transport|quaternary ammonium group transport|carnitine transport|apical plasma membrane|PDZ domain binding|xenobiotic transport|amino acid import across plasma membrane|carnitine transmembrane transport hsa05231 Choline metabolism in cancer SLC22A5 251.6725623 273.6288511 229.7162735 0.839517736 -0.252367291 0.453968085 1 4.357824195 3.597251147 6584 solute carrier family 22 member 5 "GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006814,GO:0009609,GO:0015226,GO:0015293,GO:0015651,GO:0015697,GO:0015879,GO:0016021,GO:0016324,GO:0030165,GO:0031526,GO:0042910,GO:0060731,GO:0070062,GO:0070715,GO:0150104,GO:1901235,GO:1902270,GO:1902603,GO:1990961" protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|sodium ion transport|response to symbiotic bacterium|carnitine transmembrane transporter activity|symporter activity|quaternary ammonium group transmembrane transporter activity|quaternary ammonium group transport|carnitine transport|integral component of membrane|apical plasma membrane|PDZ domain binding|brush border membrane|xenobiotic transmembrane transporter activity|positive regulation of intestinal epithelial structure maintenance|extracellular exosome|sodium-dependent organic cation transport|transport across blood-brain barrier|(R)-carnitine transmembrane transporter activity|(R)-carnitine transmembrane transport|carnitine transmembrane transport|xenobiotic detoxification by transmembrane export across the plasma membrane hsa05231 Choline metabolism in cancer SLC23A1 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.057518968 0.052248038 9963 solute carrier family 23 member 1 "GO:0005215,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0006814,GO:0007420,GO:0008520,GO:0009636,GO:0009925,GO:0015081,GO:0015205,GO:0015229,GO:0015851,GO:0015882,GO:0016324,GO:0019852,GO:0030324,GO:0033300,GO:0035725,GO:0043229,GO:0070062,GO:0070837,GO:0070904" transporter activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|sodium ion transport|brain development|L-ascorbate:sodium symporter activity|response to toxic substance|basal plasma membrane|sodium ion transmembrane transporter activity|nucleobase transmembrane transporter activity|L-ascorbic acid transmembrane transporter activity|nucleobase transport|L-ascorbic acid transmembrane transport|apical plasma membrane|L-ascorbic acid metabolic process|lung development|dehydroascorbic acid transmembrane transporter activity|sodium ion transmembrane transport|intracellular organelle|extracellular exosome|dehydroascorbic acid transport|transepithelial L-ascorbic acid transport hsa04977 Vitamin digestion and absorption SLC23A2 1784.007638 1933.088994 1634.926281 0.845758414 -0.241682471 0.308289784 1 14.56110187 12.10909665 9962 solute carrier family 23 member 2 "GO:0005215,GO:0005737,GO:0005886,GO:0005887,GO:0006814,GO:0006979,GO:0008520,GO:0009925,GO:0015229,GO:0015882,GO:0016021,GO:0016323,GO:0016324,GO:0019852,GO:0070904,GO:0071361,GO:1901215,GO:1903861" transporter activity|cytoplasm|plasma membrane|integral component of plasma membrane|sodium ion transport|response to oxidative stress|L-ascorbate:sodium symporter activity|basal plasma membrane|L-ascorbic acid transmembrane transporter activity|L-ascorbic acid transmembrane transport|integral component of membrane|basolateral plasma membrane|apical plasma membrane|L-ascorbic acid metabolic process|transepithelial L-ascorbic acid transport|cellular response to ethanol|negative regulation of neuron death|positive regulation of dendrite extension SLC23A3 24.37549873 34.33365813 14.41733934 0.419918533 -1.251818634 0.11363035 1 0.781041872 0.322485757 151295 solute carrier family 23 member 3 "GO:0005215,GO:0016021,GO:0022857,GO:0055085" transporter activity|integral component of membrane|transmembrane transporter activity|transmembrane transport SLC24A1 260.9570293 290.2754733 231.6385854 0.79799572 -0.325547086 0.325779054 1 1.444156661 1.133146466 9187 solute carrier family 24 member 1 "GO:0005262,GO:0005515,GO:0005886,GO:0005887,GO:0006811,GO:0006816,GO:0006874,GO:0007601,GO:0008273,GO:0009642,GO:0015293,GO:0016020,GO:0019867,GO:0035725,GO:0043025,GO:0044214,GO:0060291,GO:0060292,GO:0070588,GO:0071805,GO:0098656,GO:0098703" "calcium channel activity|protein binding|plasma membrane|integral component of plasma membrane|ion transport|calcium ion transport|cellular calcium ion homeostasis|visual perception|calcium, potassium:sodium antiporter activity|response to light intensity|symporter activity|membrane|outer membrane|sodium ion transmembrane transport|neuronal cell body|spanning component of plasma membrane|long-term synaptic potentiation|long-term synaptic depression|calcium ion transmembrane transport|potassium ion transmembrane transport|anion transmembrane transport|calcium ion import across plasma membrane" hsa04744 Phototransduction SLC25A1 2174.569079 1903.957405 2445.180752 1.284262319 0.360939912 0.12694727 1 56.04561908 70.77283447 6576 solute carrier family 25 member 1 "GO:0005634,GO:0005743,GO:0006094,GO:0006843,GO:0015137,GO:0015142,GO:0016021,GO:0046949,GO:0070062,GO:0071913" nucleus|mitochondrial inner membrane|gluconeogenesis|mitochondrial citrate transmembrane transport|citrate transmembrane transporter activity|tricarboxylic acid transmembrane transporter activity|integral component of membrane|fatty-acyl-CoA biosynthetic process|extracellular exosome|citrate secondary active transmembrane transporter activity SLC25A10 412.5315924 408.8826559 416.1805289 1.017848331 0.025522603 0.938157979 1 9.856059553 9.864102273 1468 solute carrier family 25 member 10 "GO:0005310,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005743,GO:0006094,GO:0006811,GO:0006835,GO:0006839,GO:0008272,GO:0015116,GO:0015117,GO:0015131,GO:0015140,GO:0015141,GO:0015297,GO:0015709,GO:0015729,GO:0016021,GO:0035435,GO:0070221,GO:0071422,GO:0071423,GO:1902356,GO:1902358" "dicarboxylic acid transmembrane transporter activity|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial inner membrane|gluconeogenesis|ion transport|dicarboxylic acid transport|mitochondrial transport|sulfate transport|sulfate transmembrane transporter activity|thiosulfate transmembrane transporter activity|oxaloacetate transmembrane transporter activity|malate transmembrane transporter activity|succinate transmembrane transporter activity|antiporter activity|thiosulfate transport|oxaloacetate transport|integral component of membrane|phosphate ion transmembrane transport|sulfide oxidation, using sulfide:quinone oxidoreductase|succinate transmembrane transport|malate transmembrane transport|oxaloacetate(2-) transmembrane transport|sulfate transmembrane transport" hsa04964 Proximal tubule bicarbonate reclamation SLC25A11 937.5719231 983.1911191 891.9527272 0.907201774 -0.140504634 0.571968023 1 26.48717971 23.62712002 8402 solute carrier family 25 member 11 "GO:0003723,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005887,GO:0006094,GO:0008272,GO:0015116,GO:0015117,GO:0015131,GO:0015140,GO:0015141,GO:0015297,GO:0015367,GO:0015709,GO:0015729,GO:0015742,GO:0035435,GO:0071422,GO:0071423,GO:1902356,GO:1902358" RNA binding|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|integral component of plasma membrane|gluconeogenesis|sulfate transport|sulfate transmembrane transporter activity|thiosulfate transmembrane transporter activity|oxaloacetate transmembrane transporter activity|malate transmembrane transporter activity|succinate transmembrane transporter activity|antiporter activity|oxoglutarate:malate antiporter activity|thiosulfate transport|oxaloacetate transport|alpha-ketoglutarate transport|phosphate ion transmembrane transport|succinate transmembrane transport|malate transmembrane transport|oxaloacetate(2-) transmembrane transport|sulfate transmembrane transport SLC25A12 922.2575945 1022.726847 821.7883424 0.803526714 -0.315582106 0.202686183 1 13.51016141 10.6741189 8604 solute carrier family 25 member 12 "GO:0005313,GO:0005509,GO:0005739,GO:0005743,GO:0006094,GO:0006537,GO:0006810,GO:0010907,GO:0015183,GO:0015810,GO:0015813,GO:0016021,GO:0022857,GO:0031643,GO:0042802,GO:0043490,GO:0051592,GO:0070778,GO:1904024,GO:2001171" L-glutamate transmembrane transporter activity|calcium ion binding|mitochondrion|mitochondrial inner membrane|gluconeogenesis|glutamate biosynthetic process|transport|positive regulation of glucose metabolic process|L-aspartate transmembrane transporter activity|aspartate transmembrane transport|L-glutamate transmembrane transport|integral component of membrane|transmembrane transporter activity|positive regulation of myelination|identical protein binding|malate-aspartate shuttle|response to calcium ion|L-aspartate transmembrane transport|negative regulation of glucose catabolic process to lactate via pyruvate|positive regulation of ATP biosynthetic process SLC25A13 628.3639816 675.2286098 581.4993534 0.861188855 -0.215598446 0.409783622 1 10.29885964 8.720848036 10165 solute carrier family 25 member 13 "GO:0005313,GO:0005509,GO:0005739,GO:0005743,GO:0005887,GO:0006094,GO:0006754,GO:0006810,GO:0006839,GO:0015183,GO:0015810,GO:0015813,GO:0022857,GO:0042802,GO:0043490,GO:0045333,GO:0051592,GO:0070778" L-glutamate transmembrane transporter activity|calcium ion binding|mitochondrion|mitochondrial inner membrane|integral component of plasma membrane|gluconeogenesis|ATP biosynthetic process|transport|mitochondrial transport|L-aspartate transmembrane transporter activity|aspartate transmembrane transport|L-glutamate transmembrane transport|transmembrane transporter activity|identical protein binding|malate-aspartate shuttle|cellular respiration|response to calcium ion|L-aspartate transmembrane transport SLC25A14 351.8504338 329.8112008 373.8896669 1.133647572 0.180972205 0.550772106 1 4.321487262 4.817064682 9016 solute carrier family 25 member 14 "GO:0005739,GO:0005743,GO:0005887,GO:0006839,GO:0008272,GO:0009060,GO:0015116,GO:0015117,GO:0015131,GO:0015140,GO:0015141,GO:0015297,GO:0015709,GO:0015729,GO:0035435,GO:0071422,GO:0071423,GO:1902356,GO:1902358,GO:1902600" mitochondrion|mitochondrial inner membrane|integral component of plasma membrane|mitochondrial transport|sulfate transport|aerobic respiration|sulfate transmembrane transporter activity|thiosulfate transmembrane transporter activity|oxaloacetate transmembrane transporter activity|malate transmembrane transporter activity|succinate transmembrane transporter activity|antiporter activity|thiosulfate transport|oxaloacetate transport|phosphate ion transmembrane transport|succinate transmembrane transport|malate transmembrane transport|oxaloacetate(2-) transmembrane transport|sulfate transmembrane transport|proton transmembrane transport SLC25A15 480.1043889 479.6307999 480.577978 1.001974807 0.002846234 1 1 6.699035401 6.599944041 10166 solute carrier family 25 member 15 "GO:0000050,GO:0000064,GO:0005743,GO:0016021,GO:1990575" urea cycle|L-ornithine transmembrane transporter activity|mitochondrial inner membrane|integral component of membrane|mitochondrial L-ornithine transmembrane transport SLC25A16 507.1702412 496.277422 518.0630603 1.043898105 0.061980897 0.826594362 1 3.389482198 3.479065818 8034 solute carrier family 25 member 16 "GO:0005739,GO:0005743,GO:0006839,GO:0015291,GO:0015297,GO:0016021,GO:0055085" mitochondrion|mitochondrial inner membrane|mitochondrial transport|secondary active transmembrane transporter activity|antiporter activity|integral component of membrane|transmembrane transport SLC25A17 885.402774 850.0181421 920.7874058 1.08325618 0.115374468 0.645539318 1 19.90518033 21.20159189 10478 solute carrier family 25 member 17 "GO:0000295,GO:0001561,GO:0005347,GO:0005515,GO:0005777,GO:0005778,GO:0005779,GO:0006635,GO:0015217,GO:0015228,GO:0015230,GO:0015866,GO:0015867,GO:0015908,GO:0016020,GO:0035349,GO:0035350,GO:0035352,GO:0044610,GO:0051087,GO:0051724,GO:0080121,GO:0080122" adenine nucleotide transmembrane transporter activity|fatty acid alpha-oxidation|ATP transmembrane transporter activity|protein binding|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|fatty acid beta-oxidation|ADP transmembrane transporter activity|coenzyme A transmembrane transporter activity|FAD transmembrane transporter activity|ADP transport|ATP transport|fatty acid transport|membrane|coenzyme A transmembrane transport|FAD transmembrane transport|NAD transmembrane transport|FMN transmembrane transporter activity|chaperone binding|NAD transmembrane transporter activity|AMP transport|AMP transmembrane transporter activity hsa04146 Peroxisome SLC25A19 231.7908421 218.4869154 245.0947688 1.121782366 0.165792809 0.637661947 1 3.976891238 4.386554213 60386 solute carrier family 25 member 19 "GO:0005634,GO:0005743,GO:0015234,GO:0030233,GO:0030302,GO:0030974,GO:0031305,GO:0042723,GO:0071934,GO:0090422" nucleus|mitochondrial inner membrane|thiamine transmembrane transporter activity|deoxynucleotide transmembrane transporter activity|deoxynucleotide transport|thiamine pyrophosphate transmembrane transport|integral component of mitochondrial inner membrane|thiamine-containing compound metabolic process|thiamine transmembrane transport|thiamine pyrophosphate transmembrane transporter activity SLC25A20 304.0605923 261.1438845 346.9773001 1.328682465 0.409996363 0.191171757 1 7.838452844 10.24053702 788 solute carrier family 25 member 20 "GO:0001701,GO:0005515,GO:0005739,GO:0005743,GO:0005829,GO:0006853,GO:0015227,GO:0016021,GO:1902603,GO:1902616" in utero embryonic development|protein binding|mitochondrion|mitochondrial inner membrane|cytosol|carnitine shuttle|acyl carnitine transmembrane transporter activity|integral component of membrane|carnitine transmembrane transport|acyl carnitine transmembrane transport hsa04714 Thermogenesis SLC25A21 28.66610199 20.80827765 36.52392633 1.755259466 0.811684309 0.278850963 1 0.219509692 0.378849051 89874 solute carrier family 25 member 21 "GO:0005743,GO:0006554,GO:0015139,GO:0016021,GO:1990550" mitochondrial inner membrane|lysine catabolic process|alpha-ketoglutarate transmembrane transporter activity|integral component of membrane|mitochondrial alpha-ketoglutarate transmembrane transport SLC25A22 424.684436 462.9841778 386.3846943 0.834552697 -0.260924945 0.360730975 1 6.89414471 5.657249578 79751 solute carrier family 25 member 22 "GO:0005313,GO:0005743,GO:0006810,GO:0006811,GO:0015183,GO:0015293,GO:0015810,GO:0015813,GO:0016021,GO:0022857,GO:0043490,GO:0070778" L-glutamate transmembrane transporter activity|mitochondrial inner membrane|transport|ion transport|L-aspartate transmembrane transporter activity|symporter activity|aspartate transmembrane transport|L-glutamate transmembrane transport|integral component of membrane|transmembrane transporter activity|malate-aspartate shuttle|L-aspartate transmembrane transport SLC25A23 751.7234526 747.0171677 756.4297374 1.012600205 0.018064682 0.948912934 1 9.548966056 9.507482598 79085 solute carrier family 25 member 23 "GO:0002082,GO:0005347,GO:0005509,GO:0005515,GO:0005739,GO:0005743,GO:0006851,GO:0015867,GO:0016021,GO:0036444,GO:0043457,GO:0051282,GO:0051561,GO:0071277,GO:0097274,GO:1900069" regulation of oxidative phosphorylation|ATP transmembrane transporter activity|calcium ion binding|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial calcium ion transmembrane transport|ATP transport|integral component of membrane|calcium import into the mitochondrion|regulation of cellular respiration|regulation of sequestering of calcium ion|positive regulation of mitochondrial calcium ion concentration|cellular response to calcium ion|urea homeostasis|regulation of cellular hyperosmotic salinity response SLC25A24 2609.701699 2477.225455 2742.177942 1.106955339 0.146597016 0.535782323 1 28.80910211 31.3567469 29957 solute carrier family 25 member 24 "GO:0005347,GO:0005509,GO:0005739,GO:0005743,GO:0006839,GO:0010941,GO:0015867,GO:0016021,GO:0034599,GO:0055085,GO:0071277" ATP transmembrane transporter activity|calcium ion binding|mitochondrion|mitochondrial inner membrane|mitochondrial transport|regulation of cell death|ATP transport|integral component of membrane|cellular response to oxidative stress|transmembrane transport|cellular response to calcium ion SLC25A25 383.2219806 295.4775427 470.9664184 1.59391612 0.67257571 0.021688147 0.822216713 3.196653839 5.009936845 114789 solute carrier family 25 member 25 "GO:0002021,GO:0005347,GO:0005509,GO:0005743,GO:0014823,GO:0015867,GO:0016021,GO:0032094,GO:0035264,GO:0043010,GO:0045333,GO:0046034,GO:0060612,GO:0070588" response to dietary excess|ATP transmembrane transporter activity|calcium ion binding|mitochondrial inner membrane|response to activity|ATP transport|integral component of membrane|response to food|multicellular organism growth|camera-type eye development|cellular respiration|ATP metabolic process|adipose tissue development|calcium ion transmembrane transport SLC25A26 167.2153699 163.3449796 171.0857602 1.047389155 0.066797572 0.878941761 1 1.225217336 1.261805408 115286 solute carrier family 25 member 26 "GO:0000095,GO:0005739,GO:0005743,GO:0006811,GO:0015805,GO:0016021,GO:1901962" S-adenosyl-L-methionine transmembrane transporter activity|mitochondrion|mitochondrial inner membrane|ion transport|S-adenosyl-L-methionine transport|integral component of membrane|S-adenosyl-L-methionine transmembrane transport SLC25A27 311.016397 292.356301 329.6764929 1.127653113 0.173323336 0.583028466 1 5.278253876 5.852440095 9481 solute carrier family 25 member 27 "GO:0005739,GO:0005743,GO:0008284,GO:0009409,GO:0010917,GO:0016021,GO:0031966,GO:0035356,GO:0043025,GO:0043066,GO:0045177,GO:0046324,GO:0048839,GO:0051562,GO:0070997,GO:1902600" mitochondrion|mitochondrial inner membrane|positive regulation of cell population proliferation|response to cold|negative regulation of mitochondrial membrane potential|integral component of membrane|mitochondrial membrane|cellular triglyceride homeostasis|neuronal cell body|negative regulation of apoptotic process|apical part of cell|regulation of glucose import|inner ear development|negative regulation of mitochondrial calcium ion concentration|neuron death|proton transmembrane transport SLC25A28 1127.49899 1036.252227 1218.745752 1.176109175 0.234021988 0.336706427 1 10.58428264 12.23996696 81894 solute carrier family 25 member 28 "GO:0005381,GO:0005743,GO:0016021,GO:0048250,GO:0055072" iron ion transmembrane transporter activity|mitochondrial inner membrane|integral component of membrane|iron import into the mitochondrion|iron ion homeostasis SLC25A29 1387.677917 1369.18467 1406.171164 1.027013518 0.03845517 0.875407661 1 15.24215047 15.39194784 123096 solute carrier family 25 member 29 "GO:0005289,GO:0005292,GO:0005739,GO:0005743,GO:0006844,GO:0006865,GO:0015174,GO:0015227,GO:0015822,GO:0015879,GO:0016021,GO:0089709,GO:1902616,GO:1903400,GO:1903401,GO:1990575" high-affinity arginine transmembrane transporter activity|high-affinity lysine transmembrane transporter activity|mitochondrion|mitochondrial inner membrane|acyl carnitine transport|amino acid transport|basic amino acid transmembrane transporter activity|acyl carnitine transmembrane transporter activity|ornithine transport|carnitine transport|integral component of membrane|L-histidine transmembrane transport|acyl carnitine transmembrane transport|L-arginine transmembrane transport|L-lysine transmembrane transport|mitochondrial L-ornithine transmembrane transport hsa04714 Thermogenesis SLC25A3 9488.650525 8948.599805 10028.70124 1.120700608 0.164400918 0.51107512 1 78.17487719 86.14458714 5250 solute carrier family 25 member 3 "GO:0005315,GO:0005739,GO:0005743,GO:0005887,GO:0015317,GO:0016020,GO:0031305,GO:0035435,GO:0044877,GO:0070062,GO:1902600" inorganic phosphate transmembrane transporter activity|mitochondrion|mitochondrial inner membrane|integral component of plasma membrane|phosphate:proton symporter activity|membrane|integral component of mitochondrial inner membrane|phosphate ion transmembrane transport|protein-containing complex binding|extracellular exosome|proton transmembrane transport SLC25A30 656.4010506 666.9052988 645.8968024 0.968498531 -0.046178234 0.864014679 1 7.097010982 6.758426925 253512 solute carrier family 25 member 30 "GO:0003674,GO:0005515,GO:0005739,GO:0005743,GO:0006839,GO:0008150,GO:0008272,GO:0015116,GO:0015117,GO:0015131,GO:0015140,GO:0015141,GO:0015297,GO:0015709,GO:0015729,GO:0016021,GO:0035435,GO:0071422,GO:0071423,GO:1902356,GO:1902358" molecular_function|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial transport|biological_process|sulfate transport|sulfate transmembrane transporter activity|thiosulfate transmembrane transporter activity|oxaloacetate transmembrane transporter activity|malate transmembrane transporter activity|succinate transmembrane transporter activity|antiporter activity|thiosulfate transport|oxaloacetate transport|integral component of membrane|phosphate ion transmembrane transport|succinate transmembrane transport|malate transmembrane transport|oxaloacetate(2-) transmembrane transport|sulfate transmembrane transport SLC25A32 1083.493407 1117.40451 1049.582304 0.939303801 -0.090336247 0.713976229 1 20.62740401 19.05117794 81034 solute carrier family 25 member 32 "GO:0005739,GO:0005743,GO:0008517,GO:0015230,GO:0015884,GO:0016021,GO:0046655,GO:1904947,GO:1990548" mitochondrion|mitochondrial inner membrane|folic acid transmembrane transporter activity|FAD transmembrane transporter activity|folic acid transport|integral component of membrane|folic acid metabolic process|folate import into mitochondrion|mitochondrial FAD transmembrane transport SLC25A33 174.136576 181.0320156 167.2411363 0.923820772 -0.11431511 0.777863607 1 6.012038549 5.461106653 84275 solute carrier family 25 member 33 "GO:0000002,GO:0002082,GO:0005743,GO:0006390,GO:0006864,GO:0007005,GO:0008284,GO:0015218,GO:0016021,GO:0030307,GO:0031930,GO:0031966,GO:0032869,GO:0034551,GO:0051881,GO:0071156,GO:1903426,GO:1990314,GO:1990519" mitochondrial genome maintenance|regulation of oxidative phosphorylation|mitochondrial inner membrane|mitochondrial transcription|pyrimidine nucleotide transport|mitochondrion organization|positive regulation of cell population proliferation|pyrimidine nucleotide transmembrane transporter activity|integral component of membrane|positive regulation of cell growth|mitochondria-nucleus signaling pathway|mitochondrial membrane|cellular response to insulin stimulus|mitochondrial respiratory chain complex III assembly|regulation of mitochondrial membrane potential|regulation of cell cycle arrest|regulation of reactive oxygen species biosynthetic process|cellular response to insulin-like growth factor stimulus|pyrimidine nucleotide import into mitochondrion SLC25A34 4.562975582 6.242483296 2.883467868 0.461910386 -1.11431511 0.584550016 1 0.075441544 0.034264112 284723 solute carrier family 25 member 34 "GO:0001835,GO:0005743,GO:0016021" blastocyst hatching|mitochondrial inner membrane|integral component of membrane SLC25A35 208.6784397 229.9314681 187.4254114 0.815135975 -0.294887356 0.413103916 1 3.105015145 2.488656531 399512 solute carrier family 25 member 35 "GO:0005743,GO:0016021" mitochondrial inner membrane|integral component of membrane SLC25A36 2078.922771 2130.767632 2027.077911 0.951336918 -0.07197173 0.762395083 1 20.99227475 19.6365429 55186 solute carrier family 25 member 36 "GO:0000002,GO:0005739,GO:0005743,GO:0006864,GO:0007005,GO:0015218,GO:0016021,GO:0051881,GO:1990519" mitochondrial genome maintenance|mitochondrion|mitochondrial inner membrane|pyrimidine nucleotide transport|mitochondrion organization|pyrimidine nucleotide transmembrane transporter activity|integral component of membrane|regulation of mitochondrial membrane potential|pyrimidine nucleotide import into mitochondrion SLC25A37 2028.000399 2282.668059 1773.332739 0.776868425 -0.364257819 0.123652119 1 44.4118844 33.92484324 51312 solute carrier family 25 member 37 "GO:0005381,GO:0005515,GO:0005743,GO:0016021,GO:0048250,GO:0055072" iron ion transmembrane transporter activity|protein binding|mitochondrial inner membrane|integral component of membrane|iron import into the mitochondrion|iron ion homeostasis SLC25A38 668.7425926 650.2586767 687.2265085 1.056850963 0.079771942 0.761861319 1 9.989381246 10.38062528 54977 solute carrier family 25 member 38 "GO:0005739,GO:0005743,GO:0006783,GO:0015187,GO:0016021,GO:0030218,GO:1904983" mitochondrion|mitochondrial inner membrane|heme biosynthetic process|glycine transmembrane transporter activity|integral component of membrane|erythrocyte differentiation|glycine import into mitochondrion SLC25A39 2254.164542 2252.496056 2255.833029 1.001481456 0.002135707 0.994947078 1 75.98708887 74.82623561 51629 solute carrier family 25 member 39 "GO:0005743,GO:0006783,GO:0016021" mitochondrial inner membrane|heme biosynthetic process|integral component of membrane SLC25A4 446.2066494 422.4080364 470.0052625 1.112680683 0.154039628 0.587832175 1 5.106034099 5.586315217 291 solute carrier family 25 member 4 "GO:0000002,GO:0005471,GO:0005515,GO:0005739,GO:0005743,GO:0005887,GO:0006091,GO:0008637,GO:0015207,GO:0015853,GO:0015866,GO:0016020,GO:0016032,GO:0032592,GO:0050796,GO:0060546,GO:0140021,GO:1990544" mitochondrial genome maintenance|ATP:ADP antiporter activity|protein binding|mitochondrion|mitochondrial inner membrane|integral component of plasma membrane|generation of precursor metabolites and energy|apoptotic mitochondrial changes|adenine transmembrane transporter activity|adenine transport|ADP transport|membrane|viral process|integral component of mitochondrial membrane|regulation of insulin secretion|negative regulation of necroptotic process|mitochondrial ADP transmembrane transport|mitochondrial ATP transmembrane transport "hsa04020,hsa04022,hsa04217,hsa04218,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05164,hsa05166" Calcium signaling pathway|cGMP-PKG signaling pathway|Necroptosis|Cellular senescence|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Influenza A|Human T-cell leukemia virus 1 infection SLC25A40 938.419837 866.6647642 1010.17491 1.165588993 0.221059159 0.372230175 1 11.4034284 13.06929185 55972 solute carrier family 25 member 40 "GO:0005743,GO:0016021,GO:0055085" mitochondrial inner membrane|integral component of membrane|transmembrane transport SLC25A42 203.5606587 209.1231904 197.9981269 0.946801388 -0.078866274 0.839617357 1 3.000946577 2.79375507 284439 solute carrier family 25 member 42 "GO:0005347,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0015217,GO:0015228,GO:0015866,GO:0015867,GO:0016021,GO:0035349,GO:0043262,GO:0080121,GO:0080122" ATP transmembrane transporter activity|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|ADP transmembrane transporter activity|coenzyme A transmembrane transporter activity|ADP transport|ATP transport|integral component of membrane|coenzyme A transmembrane transport|adenosine-diphosphatase activity|AMP transport|AMP transmembrane transporter activity SLC25A43 1739.294993 1781.188567 1697.401418 0.952959978 -0.069512469 0.771439504 1 27.4023523 25.67637359 203427 solute carrier family 25 member 43 "GO:0005743,GO:0016021,GO:0055085" mitochondrial inner membrane|integral component of membrane|transmembrane transport SLC25A44 549.3862613 582.6317743 516.1407484 0.885878133 -0.174819849 0.516393679 1 4.019907817 3.501557435 9673 solute carrier family 25 member 44 "GO:0005739,GO:0009083,GO:0015658,GO:0015803,GO:0016021,GO:0031966,GO:0055085,GO:0120161" mitochondrion|branched-chain amino acid catabolic process|branched-chain amino acid transmembrane transporter activity|branched-chain amino acid transport|integral component of membrane|mitochondrial membrane|transmembrane transport|regulation of cold-induced thermogenesis SLC25A45 28.77995846 36.41448589 21.14543103 0.580687342 -0.784166508 0.293285448 1 0.613438821 0.350255364 283130 solute carrier family 25 member 45 "GO:0005743,GO:0006844,GO:0006865,GO:0015227,GO:0016021,GO:1902616" mitochondrial inner membrane|acyl carnitine transport|amino acid transport|acyl carnitine transmembrane transporter activity|integral component of membrane|acyl carnitine transmembrane transport SLC25A46 1507.772107 1494.034335 1521.509878 1.018390168 0.026290396 0.915105003 1 16.44675465 16.46893784 91137 solute carrier family 25 member 46 "GO:0005515,GO:0005739,GO:0005741,GO:0016021,GO:0090149" protein binding|mitochondrion|mitochondrial outer membrane|integral component of membrane|mitochondrial membrane fission SLC25A5 14400.67076 13340.1868 15461.15471 1.15899087 0.212869201 0.415223932 1 544.7140409 620.7543383 292 solute carrier family 25 member 5 "GO:0000295,GO:0003723,GO:0005471,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005887,GO:0007059,GO:0008284,GO:0015207,GO:0015853,GO:0016020,GO:0016032,GO:0031625,GO:0042645,GO:0045121,GO:0050796,GO:0051503,GO:0071817,GO:0140021,GO:1901029,GO:1990544,GO:1990830" adenine nucleotide transmembrane transporter activity|RNA binding|ATP:ADP antiporter activity|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|integral component of plasma membrane|chromosome segregation|positive regulation of cell population proliferation|adenine transmembrane transporter activity|adenine transport|membrane|viral process|ubiquitin protein ligase binding|mitochondrial nucleoid|membrane raft|regulation of insulin secretion|adenine nucleotide transport|MMXD complex|mitochondrial ADP transmembrane transport|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|mitochondrial ATP transmembrane transport|cellular response to leukemia inhibitory factor "hsa04020,hsa04022,hsa04217,hsa04218,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05164,hsa05166" Calcium signaling pathway|cGMP-PKG signaling pathway|Necroptosis|Cellular senescence|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Influenza A|Human T-cell leukemia virus 1 infection SLC25A51 303.9215838 307.9625093 299.8806583 0.97375703 -0.038366257 0.91339354 1 14.03534851 13.43832022 92014 solute carrier family 25 member 51 "GO:0005739,GO:0005743,GO:0016021,GO:0051724,GO:1990549" mitochondrion|mitochondrial inner membrane|integral component of membrane|NAD transmembrane transporter activity|mitochondrial NAD transmembrane transport SLC25A53 52.16473311 44.73779695 59.59166927 1.332020648 0.413616446 0.496324702 1 0.300929418 0.394136613 401612 solute carrier family 25 member 53 "GO:0005743,GO:0016021" mitochondrial inner membrane|integral component of membrane SLC25A6-2 245.762202 232.0122958 259.5121081 1.118527392 0.161600587 0.639061757 1 8.533473334 9.3852023 293 solute carrier family 25 member 6 SLC26A11 234.4661043 238.2547791 230.6774294 0.968196442 -0.046628302 0.904432033 1 3.619476137 3.445723133 284129 solute carrier family 26 member 11 "GO:0005515,GO:0005654,GO:0005765,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0006811,GO:0008271,GO:0008272,GO:0008509,GO:0015116,GO:0015301,GO:0016021,GO:0043231,GO:0070062,GO:1902358" protein binding|nucleoplasm|lysosomal membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|ion transport|secondary active sulfate transmembrane transporter activity|sulfate transport|anion transmembrane transporter activity|sulfate transmembrane transporter activity|anion:anion antiporter activity|integral component of membrane|intracellular membrane-bounded organelle|extracellular exosome|sulfate transmembrane transport SLC26A2 1075.312906 1243.29459 907.3312225 0.729779756 -0.454466963 0.062790185 1 8.345157487 5.988216968 1836 solute carrier family 26 member 2 "GO:0001503,GO:0005886,GO:0005887,GO:0006811,GO:0008271,GO:0015106,GO:0015108,GO:0015116,GO:0015301,GO:0015701,GO:0016020,GO:0016324,GO:0019531,GO:0019532,GO:0031528,GO:0050428,GO:0070062,GO:1902358,GO:1902476" ossification|plasma membrane|integral component of plasma membrane|ion transport|secondary active sulfate transmembrane transporter activity|bicarbonate transmembrane transporter activity|chloride transmembrane transporter activity|sulfate transmembrane transporter activity|anion:anion antiporter activity|bicarbonate transport|membrane|apical plasma membrane|oxalate transmembrane transporter activity|oxalate transport|microvillus membrane|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|extracellular exosome|sulfate transmembrane transport|chloride transmembrane transport SLC26A4 10.68657199 15.60620824 5.766935736 0.369528309 -1.436243205 0.20707843 1 0.160817658 0.058432252 5172 solute carrier family 26 member 4 "GO:0005886,GO:0005887,GO:0006811,GO:0006885,GO:0007605,GO:0008271,GO:0008272,GO:0015106,GO:0015108,GO:0015111,GO:0015116,GO:0015301,GO:0015698,GO:0015701,GO:0015705,GO:0016021,GO:0016324,GO:0019531,GO:0019532,GO:0031526,GO:0032880,GO:0070062,GO:1902358,GO:1902476" plasma membrane|integral component of plasma membrane|ion transport|regulation of pH|sensory perception of sound|secondary active sulfate transmembrane transporter activity|sulfate transport|bicarbonate transmembrane transporter activity|chloride transmembrane transporter activity|iodide transmembrane transporter activity|sulfate transmembrane transporter activity|anion:anion antiporter activity|inorganic anion transport|bicarbonate transport|iodide transport|integral component of membrane|apical plasma membrane|oxalate transmembrane transporter activity|oxalate transport|brush border membrane|regulation of protein localization|extracellular exosome|sulfate transmembrane transport|chloride transmembrane transport hsa04918 Thyroid hormone synthesis SLC26A6 555.673404 583.6721882 527.6746198 0.9040599 -0.145509732 0.589281175 1 10.96427735 9.746493497 65010 solute carrier family 26 member 6 "GO:0005254,GO:0005783,GO:0005886,GO:0005887,GO:0006811,GO:0006821,GO:0008271,GO:0008272,GO:0012506,GO:0015106,GO:0015108,GO:0015116,GO:0015301,GO:0015499,GO:0015562,GO:0015660,GO:0015701,GO:0015724,GO:0015797,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0019531,GO:0019532,GO:0030165,GO:0030321,GO:0030659,GO:0031526,GO:0031982,GO:0034707,GO:0042045,GO:0046724,GO:0048240,GO:0050892,GO:0051453,GO:0051454,GO:0070633,GO:0071320,GO:0071332,GO:0071346,GO:0097225,GO:1902358,GO:1902476,GO:2001150" chloride channel activity|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|ion transport|chloride transport|secondary active sulfate transmembrane transporter activity|sulfate transport|vesicle membrane|bicarbonate transmembrane transporter activity|chloride transmembrane transporter activity|sulfate transmembrane transporter activity|anion:anion antiporter activity|formate transmembrane transporter activity|efflux transmembrane transporter activity|formate efflux transmembrane transporter activity|bicarbonate transport|formate transport|mannitol transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|oxalate transmembrane transporter activity|oxalate transport|PDZ domain binding|transepithelial chloride transport|cytoplasmic vesicle membrane|brush border membrane|vesicle|chloride channel complex|epithelial fluid transport|oxalic acid secretion|sperm capacitation|intestinal absorption|regulation of intracellular pH|intracellular pH elevation|transepithelial transport|cellular response to cAMP|cellular response to fructose stimulus|cellular response to interferon-gamma|sperm midpiece|sulfate transmembrane transport|chloride transmembrane transport|positive regulation of dipeptide transmembrane transport hsa04978 Mineral absorption SLC26A7 7.203639252 12.48496659 1.922311912 0.153970129 -2.699277611 0.067487328 1 0.112913018 0.017094314 115111 solute carrier family 26 member 7 "GO:0001696,GO:0005254,GO:0005737,GO:0005768,GO:0005886,GO:0005887,GO:0006811,GO:0006820,GO:0006821,GO:0008271,GO:0008272,GO:0015106,GO:0015108,GO:0015116,GO:0015301,GO:0015701,GO:0016323,GO:0019531,GO:0019532,GO:0055038,GO:1902358,GO:1902476" gastric acid secretion|chloride channel activity|cytoplasm|endosome|plasma membrane|integral component of plasma membrane|ion transport|anion transport|chloride transport|secondary active sulfate transmembrane transporter activity|sulfate transport|bicarbonate transmembrane transporter activity|chloride transmembrane transporter activity|sulfate transmembrane transporter activity|anion:anion antiporter activity|bicarbonate transport|basolateral plasma membrane|oxalate transmembrane transporter activity|oxalate transport|recycling endosome membrane|sulfate transmembrane transport|chloride transmembrane transport hsa04971 Gastric acid secretion SLC26A9 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.034416308 0 115019 solute carrier family 26 member 9 "GO:0005254,GO:0005886,GO:0005887,GO:0006811,GO:0006820,GO:0006821,GO:0008271,GO:0009986,GO:0010628,GO:0015106,GO:0015108,GO:0015116,GO:0015301,GO:0015701,GO:0016324,GO:0019531,GO:0019532,GO:0051117,GO:0070062,GO:1902358,GO:1902476" chloride channel activity|plasma membrane|integral component of plasma membrane|ion transport|anion transport|chloride transport|secondary active sulfate transmembrane transporter activity|cell surface|positive regulation of gene expression|bicarbonate transmembrane transporter activity|chloride transmembrane transporter activity|sulfate transmembrane transporter activity|anion:anion antiporter activity|bicarbonate transport|apical plasma membrane|oxalate transmembrane transporter activity|oxalate transport|ATPase binding|extracellular exosome|sulfate transmembrane transport|chloride transmembrane transport hsa04978 Mineral absorption SLC27A1 428.554212 400.5593448 456.5490791 1.139778874 0.188753958 0.509616252 1 5.308446992 5.949209553 376497 solute carrier family 27 member 1 "GO:0000166,GO:0001579,GO:0001676,GO:0004467,GO:0005324,GO:0005515,GO:0005743,GO:0005783,GO:0005886,GO:0005887,GO:0006646,GO:0006654,GO:0006655,GO:0006656,GO:0006659,GO:0006661,GO:0009409,GO:0009925,GO:0010867,GO:0015225,GO:0015245,GO:0015562,GO:0015878,GO:0015909,GO:0015911,GO:0016020,GO:0019216,GO:0031652,GO:0031957,GO:0032049,GO:0032868,GO:0033211,GO:0044381,GO:0044539,GO:0047676,GO:0071072,GO:0071902,GO:0090434,GO:0140115,GO:0150104,GO:1905135,GO:1990379" nucleotide binding|medium-chain fatty acid transport|long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity|protein binding|mitochondrial inner membrane|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|phosphatidylethanolamine biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylglycerol biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylserine biosynthetic process|phosphatidylinositol biosynthetic process|response to cold|basal plasma membrane|positive regulation of triglyceride biosynthetic process|biotin transmembrane transporter activity|fatty acid transmembrane transporter activity|efflux transmembrane transporter activity|biotin transport|long-chain fatty acid transport|long-chain fatty acid import across plasma membrane|membrane|regulation of lipid metabolic process|positive regulation of heat generation|very long-chain fatty acid-CoA ligase activity|cardiolipin biosynthetic process|response to insulin|adiponectin-activated signaling pathway|glucose import in response to insulin stimulus|long-chain fatty acid import into cell|arachidonate-CoA ligase activity|negative regulation of phospholipid biosynthetic process|positive regulation of protein serine/threonine kinase activity|oleoyl-CoA ligase activity|export across plasma membrane|transport across blood-brain barrier|biotin import across plasma membrane|lipid transport across blood-brain barrier "hsa03320,hsa04931,hsa04975" PPAR signaling pathway|Insulin resistance|Fat digestion and absorption SLC27A2 9.046693237 10.40413883 7.689247648 0.739056617 -0.436243205 0.791668951 1 0.232906782 0.169250914 11001 solute carrier family 27 member 2 "GO:0001561,GO:0001676,GO:0004467,GO:0005324,GO:0005524,GO:0005778,GO:0005779,GO:0005783,GO:0005788,GO:0005789,GO:0005829,GO:0005886,GO:0006625,GO:0006635,GO:0006699,GO:0015245,GO:0019899,GO:0030176,GO:0031957,GO:0035579,GO:0042760,GO:0043312,GO:0044539,GO:0047676,GO:0047747,GO:0050197,GO:0070062,GO:0070251,GO:0097089" fatty acid alpha-oxidation|long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity|ATP binding|peroxisomal membrane|integral component of peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|cytosol|plasma membrane|protein targeting to peroxisome|fatty acid beta-oxidation|bile acid biosynthetic process|fatty acid transmembrane transporter activity|enzyme binding|integral component of endoplasmic reticulum membrane|very long-chain fatty acid-CoA ligase activity|specific granule membrane|very long-chain fatty acid catabolic process|neutrophil degranulation|long-chain fatty acid import into cell|arachidonate-CoA ligase activity|cholate-CoA ligase activity|phytanate-CoA ligase activity|extracellular exosome|pristanate-CoA ligase activity|methyl-branched fatty acid metabolic process "hsa03320,hsa04146,hsa04931" PPAR signaling pathway|Peroxisome|Insulin resistance SLC27A3 74.18200134 67.62690237 80.7371003 1.19386069 0.2556345 0.638814285 1 1.57054982 1.84364181 11000 solute carrier family 27 member 3 "GO:0001676,GO:0004467,GO:0005324,GO:0005524,GO:0005739,GO:0005783,GO:0015908,GO:0015909,GO:0016020,GO:0016021,GO:0031957,GO:0031966,GO:0047676" long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity|ATP binding|mitochondrion|endoplasmic reticulum|fatty acid transport|long-chain fatty acid transport|membrane|integral component of membrane|very long-chain fatty acid-CoA ligase activity|mitochondrial membrane|arachidonate-CoA ligase activity hsa04931 Insulin resistance SLC27A4 774.2653438 859.3818671 689.1488204 0.80191222 -0.318483773 0.207519453 1 14.1554416 11.16147092 10999 solute carrier family 27 member 4 "GO:0000166,GO:0001579,GO:0001676,GO:0004467,GO:0005324,GO:0005783,GO:0005789,GO:0005886,GO:0005902,GO:0006631,GO:0007584,GO:0015908,GO:0015909,GO:0016020,GO:0016021,GO:0031526,GO:0031957,GO:0042760,GO:0043065,GO:0043588,GO:0044381,GO:0044539,GO:0046627,GO:0047676,GO:0062003,GO:0090433,GO:0090434,GO:0090630,GO:0150104,GO:1990379" "nucleotide binding|medium-chain fatty acid transport|long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|microvillus|fatty acid metabolic process|response to nutrient|fatty acid transport|long-chain fatty acid transport|membrane|integral component of membrane|brush border membrane|very long-chain fatty acid-CoA ligase activity|very long-chain fatty acid catabolic process|positive regulation of apoptotic process|skin development|glucose import in response to insulin stimulus|long-chain fatty acid import into cell|negative regulation of insulin receptor signaling pathway|arachidonate-CoA ligase activity|negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity|palmitoyl-CoA ligase activity|oleoyl-CoA ligase activity|activation of GTPase activity|transport across blood-brain barrier|lipid transport across blood-brain barrier" "hsa03320,hsa04931,hsa04975" PPAR signaling pathway|Insulin resistance|Fat digestion and absorption SLC28A3 3.601819626 6.242483296 0.961155956 0.153970129 -2.699277611 0.237188726 1 0.038670907 0.00585453 64078 solute carrier family 28 member 3 "GO:0005337,GO:0005345,GO:0005415,GO:0005789,GO:0005886,GO:0005887,GO:0015213,GO:0015293,GO:0015389,GO:0015390,GO:0015855,GO:0015860,GO:0015862,GO:0015864,GO:0031526,GO:0072531,GO:1901642,GO:1904823" nucleoside transmembrane transporter activity|purine nucleobase transmembrane transporter activity|nucleoside:sodium symporter activity|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|uridine transmembrane transporter activity|symporter activity|pyrimidine- and adenine-specific:sodium symporter activity|purine-specific nucleoside:sodium symporter activity|pyrimidine nucleobase transport|purine nucleoside transmembrane transport|uridine transport|pyrimidine nucleoside transport|brush border membrane|pyrimidine-containing compound transmembrane transport|nucleoside transmembrane transport|purine nucleobase transmembrane transport SLC29A1 1133.111826 1120.525752 1145.6979 1.022464587 0.032050876 0.898809971 1 19.32161548 19.42508325 2030 solute carrier family 29 member 1 (Augustine blood group) "GO:0001504,GO:0005326,GO:0005337,GO:0005886,GO:0005887,GO:0006139,GO:0006836,GO:0007595,GO:0015211,GO:0015213,GO:0015858,GO:0015860,GO:0015862,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0030431,GO:0032238,GO:0060079,GO:0071333,GO:0071456,GO:0072531,GO:0098793,GO:0098794,GO:0098810,GO:0150104,GO:1901642" neurotransmitter uptake|neurotransmitter transmembrane transporter activity|nucleoside transmembrane transporter activity|plasma membrane|integral component of plasma membrane|nucleobase-containing compound metabolic process|neurotransmitter transport|lactation|purine nucleoside transmembrane transporter activity|uridine transmembrane transporter activity|nucleoside transport|purine nucleoside transmembrane transport|uridine transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|sleep|adenosine transport|excitatory postsynaptic potential|cellular response to glucose stimulus|cellular response to hypoxia|pyrimidine-containing compound transmembrane transport|presynapse|postsynapse|neurotransmitter reuptake|transport across blood-brain barrier|nucleoside transmembrane transport hsa05034 Alcoholism SLC29A2 10.92937619 9.363724944 12.49502743 1.334407781 0.416199607 0.772652545 1 0.130136664 0.17074949 3177 solute carrier family 29 member 2 "GO:0001504,GO:0005326,GO:0005337,GO:0005730,GO:0005886,GO:0005887,GO:0006836,GO:0015211,GO:0015213,GO:0015853,GO:0015854,GO:0015858,GO:0015860,GO:0015862,GO:0016021,GO:0016323,GO:0031965,GO:0032238,GO:0035344,GO:0035364,GO:0072531,GO:0098793,GO:0098810,GO:0150104,GO:1901642" neurotransmitter uptake|neurotransmitter transmembrane transporter activity|nucleoside transmembrane transporter activity|nucleolus|plasma membrane|integral component of plasma membrane|neurotransmitter transport|purine nucleoside transmembrane transporter activity|uridine transmembrane transporter activity|adenine transport|guanine transport|nucleoside transport|purine nucleoside transmembrane transport|uridine transport|integral component of membrane|basolateral plasma membrane|nuclear membrane|adenosine transport|hypoxanthine transport|thymine transport|pyrimidine-containing compound transmembrane transport|presynapse|neurotransmitter reuptake|transport across blood-brain barrier|nucleoside transmembrane transport hsa05034 Alcoholism SLC29A3 44.03453645 45.77821084 42.29086206 0.923820772 -0.11431511 0.89133833 1 0.911944373 0.828375507 55315 solute carrier family 29 member 3 "GO:0005337,GO:0005515,GO:0005765,GO:0005794,GO:0005886,GO:0016021,GO:0031902,GO:0043231,GO:1901642" nucleoside transmembrane transporter activity|protein binding|lysosomal membrane|Golgi apparatus|plasma membrane|integral component of membrane|late endosome membrane|intracellular membrane-bounded organelle|nucleoside transmembrane transport hsa05034 Alcoholism SLC29A4 163.5443532 130.0517353 197.036971 1.515066066 0.599380705 0.127227753 1 2.286860656 3.406767161 222962 solute carrier family 29 member 4 "GO:0001692,GO:0005326,GO:0005337,GO:0005342,GO:0005886,GO:0006836,GO:0008324,GO:0008504,GO:0015101,GO:0015562,GO:0015695,GO:0015844,GO:0016021,GO:0016323,GO:0016324,GO:0019534,GO:0042908,GO:0042910,GO:0051610,GO:0051615,GO:0051620,GO:0051625,GO:0090494,GO:0098655,GO:0098793,GO:0140115,GO:0150104,GO:1901642,GO:1901998,GO:1903825" histamine metabolic process|neurotransmitter transmembrane transporter activity|nucleoside transmembrane transporter activity|organic acid transmembrane transporter activity|plasma membrane|neurotransmitter transport|cation transmembrane transporter activity|monoamine transmembrane transporter activity|organic cation transmembrane transporter activity|efflux transmembrane transporter activity|organic cation transport|monoamine transport|integral component of membrane|basolateral plasma membrane|apical plasma membrane|toxin transmembrane transporter activity|xenobiotic transport|xenobiotic transmembrane transporter activity|serotonin uptake|histamine uptake|norepinephrine uptake|epinephrine uptake|dopamine uptake|cation transmembrane transport|presynapse|export across plasma membrane|transport across blood-brain barrier|nucleoside transmembrane transport|toxin transport|organic acid transmembrane transport SLC2A1 1586.814608 1525.246752 1648.382465 1.080731667 0.112008363 0.639463818 1 24.05426001 25.5611893 6513 solute carrier family 2 member 1 "GO:0000139,GO:0001666,GO:0001917,GO:0001939,GO:0005324,GO:0005355,GO:0005515,GO:0005829,GO:0005886,GO:0005887,GO:0005901,GO:0005989,GO:0007417,GO:0007565,GO:0010827,GO:0014704,GO:0015911,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0019852,GO:0019900,GO:0021987,GO:0030018,GO:0030496,GO:0030864,GO:0032868,GO:0033300,GO:0042149,GO:0042383,GO:0042470,GO:0042802,GO:0042908,GO:0042910,GO:0043621,GO:0045494,GO:0050796,GO:0055056,GO:0065003,GO:0070062,GO:0070837,GO:0071260,GO:0071474,GO:0072562,GO:0098708,GO:0098793,GO:0150104,GO:1904016,GO:1904659" Golgi membrane|response to hypoxia|photoreceptor inner segment|female pronucleus|long-chain fatty acid transporter activity|glucose transmembrane transporter activity|protein binding|cytosol|plasma membrane|integral component of plasma membrane|caveola|lactose biosynthetic process|central nervous system development|female pregnancy|regulation of glucose transmembrane transport|intercalated disc|long-chain fatty acid import across plasma membrane|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|L-ascorbic acid metabolic process|kinase binding|cerebral cortex development|Z disc|midbody|cortical actin cytoskeleton|response to insulin|dehydroascorbic acid transmembrane transporter activity|cellular response to glucose starvation|sarcolemma|melanosome|identical protein binding|xenobiotic transport|xenobiotic transmembrane transporter activity|protein self-association|photoreceptor cell maintenance|regulation of insulin secretion|D-glucose transmembrane transporter activity|protein-containing complex assembly|extracellular exosome|dehydroascorbic acid transport|cellular response to mechanical stimulus|cellular hyperosmotic response|blood microparticle|glucose import across plasma membrane|presynapse|transport across blood-brain barrier|response to Thyroglobulin triiodothyronine|glucose transmembrane transport "hsa04066,hsa04911,hsa04919,hsa04920,hsa04922,hsa04931,hsa04976,hsa05166,hsa05200,hsa05211,hsa05230" HIF-1 signaling pathway|Insulin secretion|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance|Bile secretion|Human T-cell leukemia virus 1 infection|Pathways in cancer|Renal cell carcinoma|Central carbon metabolism in cancer SLC2A10 83.57529441 112.3646993 54.78588949 0.487572074 -1.036312598 0.037863248 0.980643794 0.900405028 0.43166607 81031 solute carrier family 2 member 10 "GO:0005351,GO:0005886,GO:0005887,GO:0008645,GO:0010628,GO:0010629,GO:0012505,GO:0015757,GO:0016021,GO:0030511,GO:0030512,GO:0032683,GO:0033300,GO:0043588,GO:0045454,GO:0048471,GO:0055056,GO:0060392,GO:0060840,GO:0070837,GO:0072498,GO:0098708,GO:0150104,GO:1902600,GO:1902729,GO:1902730,GO:1903053,GO:1904659,GO:2001045" carbohydrate:proton symporter activity|plasma membrane|integral component of plasma membrane|hexose transmembrane transport|positive regulation of gene expression|negative regulation of gene expression|endomembrane system|galactose transmembrane transport|integral component of membrane|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of connective tissue growth factor production|dehydroascorbic acid transmembrane transporter activity|skin development|cell redox homeostasis|perinuclear region of cytoplasm|D-glucose transmembrane transporter activity|negative regulation of SMAD protein signal transduction|artery development|dehydroascorbic acid transport|embryonic skeletal joint development|glucose import across plasma membrane|transport across blood-brain barrier|proton transmembrane transport|negative regulation of proteoglycan biosynthetic process|positive regulation of proteoglycan biosynthetic process|regulation of extracellular matrix organization|glucose transmembrane transport|negative regulation of integrin-mediated signaling pathway SLC2A11 233.6634642 242.4164347 224.9104937 0.927785668 -0.108136535 0.762611288 1 3.566947774 3.253985314 66035 solute carrier family 2 member 11 "GO:0005355,GO:0005654,GO:0005886,GO:0008645,GO:0016021,GO:0030054,GO:1904659" glucose transmembrane transporter activity|nucleoplasm|plasma membrane|hexose transmembrane transport|integral component of membrane|cell junction|glucose transmembrane transport SLC2A12 127.6544902 146.6983575 108.610623 0.740367001 -0.4336875 0.315264714 1 0.929040194 0.676320788 154091 solute carrier family 2 member 12 "GO:0005886,GO:0008645,GO:0012505,GO:0016021,GO:0022857,GO:0048471,GO:1904659" plasma membrane|hexose transmembrane transport|endomembrane system|integral component of membrane|transmembrane transporter activity|perinuclear region of cytoplasm|glucose transmembrane transport SLC2A13 342.0602368 375.5894116 308.5310619 0.821458359 -0.28374065 0.349683148 1 1.433594378 1.157931907 114134 solute carrier family 2 member 13 "GO:0002020,GO:0005365,GO:0005366,GO:0005515,GO:0005737,GO:0005764,GO:0005769,GO:0005886,GO:0005887,GO:0008021,GO:0015798,GO:0016020,GO:0030426,GO:0031090,GO:0042995,GO:0043231,GO:0044297,GO:0051117,GO:0055085,GO:0071944,GO:0097450,GO:0150104,GO:1902004" protease binding|myo-inositol transmembrane transporter activity|myo-inositol:proton symporter activity|protein binding|cytoplasm|lysosome|early endosome|plasma membrane|integral component of plasma membrane|synaptic vesicle|myo-inositol transport|membrane|growth cone|organelle membrane|cell projection|intracellular membrane-bounded organelle|cell body|ATPase binding|transmembrane transport|cell periphery|astrocyte end-foot|transport across blood-brain barrier|positive regulation of amyloid-beta formation SLC2A3 1260.915385 1195.435551 1326.395219 1.109549752 0.149974359 0.535425567 1 16.67055089 18.18728661 6515 solute carrier family 2 member 3 "GO:0005355,GO:0005515,GO:0005536,GO:0005886,GO:0005887,GO:0005975,GO:0016021,GO:0019852,GO:0030667,GO:0035579,GO:0042995,GO:0043204,GO:0043312,GO:0070062,GO:0070821,GO:0098708,GO:0101003,GO:0150104,GO:1904659" glucose transmembrane transporter activity|protein binding|glucose binding|plasma membrane|integral component of plasma membrane|carbohydrate metabolic process|integral component of membrane|L-ascorbic acid metabolic process|secretory granule membrane|specific granule membrane|cell projection|perikaryon|neutrophil degranulation|extracellular exosome|tertiary granule membrane|glucose import across plasma membrane|ficolin-1-rich granule membrane|transport across blood-brain barrier|glucose transmembrane transport SLC2A4 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.049355535 0 6517 solute carrier family 2 member 4 "GO:0005355,GO:0005515,GO:0005771,GO:0005802,GO:0005829,GO:0005886,GO:0005887,GO:0005905,GO:0005975,GO:0007611,GO:0007614,GO:0007616,GO:0009897,GO:0010021,GO:0012505,GO:0012506,GO:0016020,GO:0016529,GO:0030136,GO:0030140,GO:0030315,GO:0030659,GO:0031550,GO:0032593,GO:0032869,GO:0042383,GO:0042593,GO:0044381,GO:0045121,GO:0045471,GO:0046323,GO:0048471,GO:0050873,GO:0055056,GO:0070062,GO:0071356,GO:0071456,GO:0071470,GO:0098694,GO:0098793,GO:0150104,GO:1904659" glucose transmembrane transporter activity|protein binding|multivesicular body|trans-Golgi network|cytosol|plasma membrane|integral component of plasma membrane|clathrin-coated pit|carbohydrate metabolic process|learning or memory|short-term memory|long-term memory|external side of plasma membrane|amylopectin biosynthetic process|endomembrane system|vesicle membrane|membrane|sarcoplasmic reticulum|clathrin-coated vesicle|trans-Golgi network transport vesicle|T-tubule|cytoplasmic vesicle membrane|positive regulation of brain-derived neurotrophic factor receptor signaling pathway|insulin-responsive compartment|cellular response to insulin stimulus|sarcolemma|glucose homeostasis|glucose import in response to insulin stimulus|membrane raft|response to ethanol|glucose import|perinuclear region of cytoplasm|brown fat cell differentiation|D-glucose transmembrane transporter activity|extracellular exosome|cellular response to tumor necrosis factor|cellular response to hypoxia|cellular response to osmotic stress|regulation of synaptic vesicle budding from presynaptic endocytic zone membrane|presynapse|transport across blood-brain barrier|glucose transmembrane transport "hsa04068,hsa04152,hsa04910,hsa04920,hsa04930,hsa04931" FoxO signaling pathway|AMPK signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Type II diabetes mellitus|Insulin resistance SLC2A4RG 1957.947912 1806.1585 2109.737323 1.168079835 0.224138882 0.343930851 1 40.82649707 46.8906037 56731 SLC2A4 regulator "GO:0000978,GO:0003700,GO:0005634,GO:0005737,GO:0006355,GO:0006357,GO:0016607,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|nucleus|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|nuclear speck|metal ion binding" SLC2A6 387.9472736 495.2370081 280.6575392 0.566713583 -0.819308314 0.005043177 0.430157521 9.86189885 5.495349824 11182 solute carrier family 2 member 6 "GO:0005353,GO:0005355,GO:0005515,GO:0005765,GO:0005886,GO:0006110,GO:0008645,GO:0015755,GO:0016020,GO:0016021,GO:0033300,GO:0070837,GO:1904659" fructose transmembrane transporter activity|glucose transmembrane transporter activity|protein binding|lysosomal membrane|plasma membrane|regulation of glycolytic process|hexose transmembrane transport|fructose transmembrane transport|membrane|integral component of membrane|dehydroascorbic acid transmembrane transporter activity|dehydroascorbic acid transport|glucose transmembrane transport SLC2A8 166.7001933 149.8195991 183.5807876 1.225345607 0.293188717 0.457252436 1 3.446377865 4.152337725 29988 solute carrier family 2 member 8 "GO:0001666,GO:0005353,GO:0005355,GO:0005536,GO:0005765,GO:0005886,GO:0005887,GO:0005975,GO:0007141,GO:0008021,GO:0008286,GO:0008645,GO:0015755,GO:0030665,GO:0033300,GO:0061024,GO:0070837,GO:1904659" response to hypoxia|fructose transmembrane transporter activity|glucose transmembrane transporter activity|glucose binding|lysosomal membrane|plasma membrane|integral component of plasma membrane|carbohydrate metabolic process|male meiosis I|synaptic vesicle|insulin receptor signaling pathway|hexose transmembrane transport|fructose transmembrane transport|clathrin-coated vesicle membrane|dehydroascorbic acid transmembrane transporter activity|membrane organization|dehydroascorbic acid transport|glucose transmembrane transport SLC2A9 10.04747816 11.44455271 8.650403604 0.755853359 -0.403821727 0.795727704 1 0.038757202 0.028804553 56606 solute carrier family 2 member 9 "GO:0005351,GO:0005355,GO:0005515,GO:0005886,GO:0008645,GO:0015143,GO:0015747,GO:0016021,GO:0016323,GO:0016324,GO:0022857,GO:0046415,GO:1902600,GO:1904659" carbohydrate:proton symporter activity|glucose transmembrane transporter activity|protein binding|plasma membrane|hexose transmembrane transport|urate transmembrane transporter activity|urate transport|integral component of membrane|basolateral plasma membrane|apical plasma membrane|transmembrane transporter activity|urate metabolic process|proton transmembrane transport|glucose transmembrane transport SLC30A1 661.3747927 747.0171677 575.7324176 0.770708415 -0.375742951 0.145924834 1 6.765133766 5.126697208 7779 solute carrier family 30 member 1 "GO:0001701,GO:0005385,GO:0005515,GO:0005737,GO:0005783,GO:0005794,GO:0005886,GO:0006829,GO:0006874,GO:0006882,GO:0019855,GO:0030315,GO:0031965,GO:0046929,GO:0070509,GO:0070574,GO:0071577,GO:0071584,GO:0071585,GO:0090281,GO:0098685,GO:0099061" in utero embryonic development|zinc ion transmembrane transporter activity|protein binding|cytoplasm|endoplasmic reticulum|Golgi apparatus|plasma membrane|zinc ion transport|cellular calcium ion homeostasis|cellular zinc ion homeostasis|calcium channel inhibitor activity|T-tubule|nuclear membrane|negative regulation of neurotransmitter secretion|calcium ion import|cadmium ion transmembrane transport|zinc ion transmembrane transport|negative regulation of zinc ion transmembrane import|detoxification of cadmium ion|negative regulation of calcium ion import|Schaffer collateral - CA1 synapse|integral component of postsynaptic density membrane hsa04978 Mineral absorption SLC30A4 258.0490237 251.7801596 264.3178879 1.049796332 0.070109461 0.843416109 1 1.493336782 1.541466148 7782 solute carrier family 30 member 4 "GO:0005385,GO:0005515,GO:0005737,GO:0005765,GO:0005770,GO:0005886,GO:0009636,GO:0010043,GO:0016021,GO:0031902,GO:0055069,GO:0061088,GO:0071577" zinc ion transmembrane transporter activity|protein binding|cytoplasm|lysosomal membrane|late endosome|plasma membrane|response to toxic substance|response to zinc ion|integral component of membrane|late endosome membrane|zinc ion homeostasis|regulation of sequestering of zinc ion|zinc ion transmembrane transport SLC30A5 1248.930504 1221.445898 1276.41511 1.045003394 0.063507628 0.795236515 1 13.85174727 14.23290134 64924 solute carrier family 30 member 5 "GO:0005385,GO:0005654,GO:0005730,GO:0005794,GO:0005887,GO:0006824,GO:0006829,GO:0006882,GO:0008270,GO:0010043,GO:0010155,GO:0016020,GO:0016324,GO:0030141,GO:0030667,GO:0071577" zinc ion transmembrane transporter activity|nucleoplasm|nucleolus|Golgi apparatus|integral component of plasma membrane|cobalt ion transport|zinc ion transport|cellular zinc ion homeostasis|zinc ion binding|response to zinc ion|regulation of proton transport|membrane|apical plasma membrane|secretory granule|secretory granule membrane|zinc ion transmembrane transport SLC30A6 768.2606342 853.1393838 683.3818847 0.801020206 -0.32008946 0.205686505 1 6.519255571 5.134671413 55676 solute carrier family 30 member 6 "GO:0000139,GO:0005385,GO:0005794,GO:0016021,GO:0071577" Golgi membrane|zinc ion transmembrane transporter activity|Golgi apparatus|integral component of membrane|zinc ion transmembrane transport SLC30A7 762.122561 780.310412 743.9347099 0.953383036 -0.068872139 0.789928256 1 4.247626738 3.98185045 148867 solute carrier family 30 member 7 "GO:0005737,GO:0005794,GO:0006829,GO:0008324,GO:0016021,GO:0031410,GO:0031982,GO:0032119,GO:0048471,GO:0098655" cytoplasm|Golgi apparatus|zinc ion transport|cation transmembrane transporter activity|integral component of membrane|cytoplasmic vesicle|vesicle|sequestering of zinc ion|perinuclear region of cytoplasm|cation transmembrane transport SLC30A9 1827.537673 1839.451745 1815.623601 0.987046062 -0.018810683 0.939172563 1 15.85403082 15.38679958 10463 solute carrier family 30 member 9 "GO:0003682,GO:0005634,GO:0005783,GO:0005856,GO:0006289,GO:0006829,GO:0006882,GO:0008324,GO:0016021,GO:0016922,GO:0030374,GO:0031410,GO:0045944,GO:0098655" chromatin binding|nucleus|endoplasmic reticulum|cytoskeleton|nucleotide-excision repair|zinc ion transport|cellular zinc ion homeostasis|cation transmembrane transporter activity|integral component of membrane|nuclear receptor binding|nuclear receptor coactivator activity|cytoplasmic vesicle|positive regulation of transcription by RNA polymerase II|cation transmembrane transport SLC31A1 1620.87528 1675.066351 1566.684208 0.935296806 -0.096503834 0.686561914 1 18.77261918 17.2641619 1317 solute carrier family 31 member 1 "GO:0005375,GO:0005770,GO:0005886,GO:0005887,GO:0006825,GO:0006878,GO:0042802,GO:0043025,GO:0055037,GO:0072719,GO:0098705" copper ion transmembrane transporter activity|late endosome|plasma membrane|integral component of plasma membrane|copper ion transport|cellular copper ion homeostasis|identical protein binding|neuronal cell body|recycling endosome|cellular response to cisplatin|copper ion import across plasma membrane "hsa01524,hsa04978" Platinum drug resistance|Mineral absorption SLC31A2 289.4400778 268.4267817 310.4533738 1.156566315 0.209847989 0.515911437 1 6.401002678 7.27930182 1318 solute carrier family 31 member 2 "GO:0005375,GO:0005515,GO:0005770,GO:0005886,GO:0005887,GO:0006825,GO:0006878,GO:0035434,GO:0055037,GO:1902311" copper ion transmembrane transporter activity|protein binding|late endosome|plasma membrane|integral component of plasma membrane|copper ion transport|cellular copper ion homeostasis|copper ion transmembrane transport|recycling endosome|regulation of copper ion transmembrane transport SLC33A1 876.7272183 912.4429751 841.0114615 0.921713997 -0.117608936 0.639378493 1 5.190854342 4.704421257 9197 solute carrier family 33 member 1 "GO:0000139,GO:0005789,GO:0005887,GO:0008521,GO:0015295,GO:0015876,GO:0016020,GO:0030509,GO:0055085,GO:0060395,GO:1902600" Golgi membrane|endoplasmic reticulum membrane|integral component of plasma membrane|acetyl-CoA transmembrane transporter activity|solute:proton symporter activity|acetyl-CoA transport|membrane|BMP signaling pathway|transmembrane transport|SMAD protein signal transduction|proton transmembrane transport hsa00604 Glycosphingolipid biosynthesis - ganglio series SLC35A1 544.3678599 513.964458 574.7712617 1.118309355 0.161319333 0.55074896 1 14.79468096 16.26817145 10559 solute carrier family 35 member A1 "GO:0000139,GO:0005456,GO:0005459,GO:0005515,GO:0005794,GO:0005887,GO:0005975,GO:0006464,GO:0008643,GO:0015297,GO:0015782,GO:0016021,GO:0030173,GO:0072334" Golgi membrane|CMP-N-acetylneuraminate transmembrane transporter activity|UDP-galactose transmembrane transporter activity|protein binding|Golgi apparatus|integral component of plasma membrane|carbohydrate metabolic process|cellular protein modification process|carbohydrate transport|antiporter activity|CMP-N-acetylneuraminate transmembrane transport|integral component of membrane|integral component of Golgi membrane|UDP-galactose transmembrane transport SLC35A2 792.6367474 786.5528953 798.7205994 1.015469658 0.022147133 0.935279039 1 14.18617181 14.16456838 7355 solute carrier family 35 member A2 "GO:0000139,GO:0005459,GO:0005654,GO:0005783,GO:0005794,GO:0006012,GO:0008643,GO:0030173,GO:0072334" Golgi membrane|UDP-galactose transmembrane transporter activity|nucleoplasm|endoplasmic reticulum|Golgi apparatus|galactose metabolic process|carbohydrate transport|integral component of Golgi membrane|UDP-galactose transmembrane transport SLC35A3 1120.037455 1067.464644 1172.610266 1.098500333 0.135535307 0.57950562 1 3.478787623 3.757502582 23443 solute carrier family 35 member A3 "GO:0000139,GO:0005459,GO:0005462,GO:0005515,GO:0005794,GO:0006047,GO:0008643,GO:0030173,GO:0072334,GO:1990569" Golgi membrane|UDP-galactose transmembrane transporter activity|UDP-N-acetylglucosamine transmembrane transporter activity|protein binding|Golgi apparatus|UDP-N-acetylglucosamine metabolic process|carbohydrate transport|integral component of Golgi membrane|UDP-galactose transmembrane transport|UDP-N-acetylglucosamine transmembrane transport SLC35A4 1088.319308 1067.464644 1109.173973 1.039073266 0.055297383 0.82407651 1 21.36857694 21.83197123 113829 solute carrier family 35 member A4 "GO:0005515,GO:0005794,GO:0008643,GO:0015165,GO:0030173,GO:0090481" protein binding|Golgi apparatus|carbohydrate transport|pyrimidine nucleotide-sugar transmembrane transporter activity|integral component of Golgi membrane|pyrimidine nucleotide-sugar transmembrane transport SLC35A5 589.6755535 580.5509465 598.8001606 1.031434303 0.044651931 0.871879406 1 6.691779051 6.786632653 55032 solute carrier family 35 member A5 "GO:0005515,GO:0008643,GO:0015165,GO:0030173,GO:0090481" protein binding|carbohydrate transport|pyrimidine nucleotide-sugar transmembrane transporter activity|integral component of Golgi membrane|pyrimidine nucleotide-sugar transmembrane transport SLC35B1 789.0695263 793.8357925 784.3032601 0.987991808 -0.017429015 0.950311527 1 23.84105641 23.16061128 10237 solute carrier family 35 member B1 "GO:0005459,GO:0005460,GO:0005515,GO:0008643,GO:0015786,GO:0022857,GO:0030173,GO:0030176,GO:0043231,GO:0072334" UDP-galactose transmembrane transporter activity|UDP-glucose transmembrane transporter activity|protein binding|carbohydrate transport|UDP-glucose transmembrane transport|transmembrane transporter activity|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|intracellular membrane-bounded organelle|UDP-galactose transmembrane transport SLC35B2 1121.83585 1076.828369 1166.843331 1.083592673 0.115822544 0.636328072 1 25.48485628 27.15310051 347734 solute carrier family 35 member B2 "GO:0000139,GO:0005515,GO:0005794,GO:0016020,GO:0016021,GO:0022857,GO:0030173,GO:0030176,GO:0043123,GO:0046963,GO:0046964,GO:0050428,GO:1902559" Golgi membrane|protein binding|Golgi apparatus|membrane|integral component of membrane|transmembrane transporter activity|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|3'-phosphoadenosine 5'-phosphosulfate transport|3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|3'-phospho-5'-adenylyl sulfate transmembrane transport SLC35B3 350.1658957 336.0536841 364.2781073 1.083987841 0.116348574 0.705319801 1 3.95034526 4.210470644 51000 solute carrier family 35 member B3 "GO:0000139,GO:0022857,GO:0030173,GO:0030176,GO:0046964,GO:0050428,GO:1902559" Golgi membrane|transmembrane transporter activity|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|3'-phospho-5'-adenylyl sulfate transmembrane transport SLC35B4 1347.433284 1359.820945 1335.045623 0.981780453 -0.026527652 0.915174195 1 10.60206641 10.23472269 84912 solute carrier family 35 member B4 "GO:0000139,GO:0005462,GO:0005464,GO:0005515,GO:0005783,GO:0005794,GO:0006111,GO:0008643,GO:0015790,GO:0022857,GO:0030173,GO:0030176,GO:1990569" Golgi membrane|UDP-N-acetylglucosamine transmembrane transporter activity|UDP-xylose transmembrane transporter activity|protein binding|endoplasmic reticulum|Golgi apparatus|regulation of gluconeogenesis|carbohydrate transport|UDP-xylose transmembrane transport|transmembrane transporter activity|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|UDP-N-acetylglucosamine transmembrane transport SLC35C1 429.5745042 452.5800389 406.5689694 0.898336061 -0.154672848 0.589969476 1 5.756283335 5.084545927 55343 solute carrier family 35 member C1 "GO:0000139,GO:0005457,GO:0005794,GO:0008643,GO:0015297,GO:0016021,GO:0030259,GO:0036066,GO:0036085,GO:0045746" Golgi membrane|GDP-fucose transmembrane transporter activity|Golgi apparatus|carbohydrate transport|antiporter activity|integral component of membrane|lipid glycosylation|protein O-linked fucosylation|GDP-fucose import into Golgi lumen|negative regulation of Notch signaling pathway SLC35C2 1081.62017 1194.395137 968.8452036 0.811159702 -0.301942113 0.216236583 1 9.703558117 7.739422521 51006 solute carrier family 35 member C2 "GO:0005654,GO:0005793,GO:0005794,GO:0005801,GO:0010629,GO:0015297,GO:0015786,GO:0016021,GO:0033116,GO:0036066,GO:0045747" nucleoplasm|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|negative regulation of gene expression|antiporter activity|UDP-glucose transmembrane transport|integral component of membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|protein O-linked fucosylation|positive regulation of Notch signaling pathway SLC35D1 620.635105 674.188196 567.082014 0.84113311 -0.249593969 0.340427697 1 5.500716238 4.549410747 23169 solute carrier family 35 member D1 "GO:0005461,GO:0005462,GO:0005463,GO:0005789,GO:0005794,GO:0006065,GO:0008643,GO:0015297,GO:0015787,GO:0015789,GO:0016021,GO:1990569" UDP-glucuronic acid transmembrane transporter activity|UDP-N-acetylglucosamine transmembrane transporter activity|UDP-N-acetylgalactosamine transmembrane transporter activity|endoplasmic reticulum membrane|Golgi apparatus|UDP-glucuronate biosynthetic process|carbohydrate transport|antiporter activity|UDP-glucuronic acid transmembrane transport|UDP-N-acetylgalactosamine transmembrane transport|integral component of membrane|UDP-N-acetylglucosamine transmembrane transport SLC35D2 1201.859014 1159.021065 1244.696963 1.073920915 0.102887755 0.673021518 1 38.01771608 40.14481881 11046 solute carrier family 35 member D2 "GO:0000139,GO:0005338,GO:0005461,GO:0005462,GO:0005463,GO:0005794,GO:0006024,GO:0008150,GO:0008643,GO:0015297,GO:0015787,GO:0015789,GO:0016021,GO:0018146,GO:1990569" Golgi membrane|nucleotide-sugar transmembrane transporter activity|UDP-glucuronic acid transmembrane transporter activity|UDP-N-acetylglucosamine transmembrane transporter activity|UDP-N-acetylgalactosamine transmembrane transporter activity|Golgi apparatus|glycosaminoglycan biosynthetic process|biological_process|carbohydrate transport|antiporter activity|UDP-glucuronic acid transmembrane transport|UDP-N-acetylgalactosamine transmembrane transport|integral component of membrane|keratan sulfate biosynthetic process|UDP-N-acetylglucosamine transmembrane transport SLC35E1 1110.886352 1117.40451 1104.368193 0.988333395 -0.016930305 0.948571565 1 11.63359832 11.30547238 79939 solute carrier family 35 member E1 "GO:0005515,GO:0005794,GO:0015297,GO:0016021,GO:0055085" protein binding|Golgi apparatus|antiporter activity|integral component of membrane|transmembrane transport SLC35E2A 424.1101233 397.4381032 450.7821434 1.134219743 0.181700175 0.527020672 1 2.878737935 3.210484017 9906 solute carrier family 35 member E2A "GO:0005515,GO:0005794,GO:0015297,GO:0016021,GO:0055085" protein binding|Golgi apparatus|antiporter activity|integral component of membrane|transmembrane transport SLC35E2B 1812.580005 1888.351197 1736.808812 0.919748834 -0.120688152 0.611791499 1 15.01233915 13.57653026 728661 solute carrier family 35 member E2B "GO:0001835,GO:0005794,GO:0015297,GO:0016021,GO:0055085" blastocyst hatching|Golgi apparatus|antiporter activity|integral component of membrane|transmembrane transport SLC35E3 589.9624027 663.7840571 516.1407484 0.777573283 -0.362949446 0.168812129 1 1.959994199 1.498536392 55508 solute carrier family 35 member E3 "GO:0005338,GO:0005515,GO:0005794,GO:0015297,GO:0015931,GO:0016021,GO:0055085,GO:1901264" nucleotide-sugar transmembrane transporter activity|protein binding|Golgi apparatus|antiporter activity|nucleobase-containing compound transport|integral component of membrane|transmembrane transport|carbohydrate derivative transport SLC35E4 419.1061987 392.2360338 445.9763636 1.137010181 0.185245172 0.520213222 1 3.467436843 3.876538409 339665 solute carrier family 35 member E4 "GO:0005515,GO:0005794,GO:0015297,GO:0016021,GO:0055085" protein binding|Golgi apparatus|antiporter activity|integral component of membrane|transmembrane transport SLC35F1 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.03233209 0 222553 solute carrier family 35 member F1 "GO:0005515,GO:0016021,GO:0022857,GO:0055085" protein binding|integral component of membrane|transmembrane transporter activity|transmembrane transport SLC35F2 1073.544694 1159.021065 988.0683228 0.852502472 -0.230224078 0.346512306 1 22.33832577 18.72481112 54733 solute carrier family 35 member F2 "GO:0003674,GO:0005575,GO:0008150,GO:0016021,GO:0022857,GO:0055085" molecular_function|cellular_component|biological_process|integral component of membrane|transmembrane transporter activity|transmembrane transport SLC35F3 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.047606439 0.02882925 148641 solute carrier family 35 member F3 "GO:0015888,GO:0016021" thiamine transport|integral component of membrane SLC35F5 1511.760155 1535.650891 1487.86942 0.9688852 -0.04560236 0.850928392 1 5.633411165 5.36679431 80255 solute carrier family 35 member F5 GO:0016021 integral component of membrane SLC35F6 618.2271847 686.6731625 549.7812068 0.800644669 -0.320765987 0.220105619 1 9.391718256 7.393601689 54978 solute carrier family 35 member F6 "GO:0005515,GO:0005654,GO:0005739,GO:0005765,GO:0005829,GO:0008284,GO:0016020,GO:0016021,GO:0022857,GO:0043231,GO:0055085,GO:0070062,GO:1901029" protein binding|nucleoplasm|mitochondrion|lysosomal membrane|cytosol|positive regulation of cell population proliferation|membrane|integral component of membrane|transmembrane transporter activity|intracellular membrane-bounded organelle|transmembrane transport|extracellular exosome|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway SLC35G1 507.1551499 533.7323218 480.577978 0.900410109 -0.151345841 0.582179826 1 5.421452808 4.799845105 159371 solute carrier family 35 member G1 "GO:0005515,GO:0005789,GO:0005886,GO:0016021,GO:0051480,GO:1990034" protein binding|endoplasmic reticulum membrane|plasma membrane|integral component of membrane|regulation of cytosolic calcium ion concentration|calcium ion export across plasma membrane SLC35G2 274.096181 281.9521622 266.2401998 0.944274368 -0.082721985 0.808873029 1 2.121724294 1.969964177 80723 solute carrier family 35 member G2 "GO:0005515,GO:0005794,GO:0005886,GO:0005887,GO:0016021" protein binding|Golgi apparatus|plasma membrane|integral component of plasma membrane|integral component of membrane SLC36A1 361.1638546 473.3883166 248.9393926 0.525867209 -0.927229557 0.00190553 0.274821698 2.057988303 1.064118935 206358 solute carrier family 36 member 1 "GO:0003333,GO:0005280,GO:0005368,GO:0005515,GO:0005765,GO:0005783,GO:0005886,GO:0006811,GO:0006865,GO:0015171,GO:0015180,GO:0015187,GO:0015193,GO:0015734,GO:0015808,GO:0015816,GO:0015824,GO:0016021,GO:0022858,GO:0032328,GO:0035524,GO:0089718,GO:1902600" amino acid transmembrane transport|amino acid:proton symporter activity|taurine transmembrane transporter activity|protein binding|lysosomal membrane|endoplasmic reticulum|plasma membrane|ion transport|amino acid transport|amino acid transmembrane transporter activity|L-alanine transmembrane transporter activity|glycine transmembrane transporter activity|L-proline transmembrane transporter activity|taurine transport|L-alanine transport|glycine transport|proline transport|integral component of membrane|alanine transmembrane transporter activity|alanine transport|proline transmembrane transport|amino acid import across plasma membrane|proton transmembrane transport hsa04974 Protein digestion and absorption SLC36A4 687.4253831 699.1581291 675.6926371 0.966437504 -0.049251654 0.8532866 1 5.613477411 5.334293812 120103 solute carrier family 36 member 4 "GO:0003333,GO:0005886,GO:0015171,GO:0015180,GO:0015193,GO:0015196,GO:0015293,GO:0015808,GO:0015824,GO:0015827,GO:0016021,GO:1904271,GO:1904556" amino acid transmembrane transport|plasma membrane|amino acid transmembrane transporter activity|L-alanine transmembrane transporter activity|L-proline transmembrane transporter activity|L-tryptophan transmembrane transporter activity|symporter activity|L-alanine transport|proline transport|tryptophan transport|integral component of membrane|L-proline import across plasma membrane|L-tryptophan transmembrane transport hsa04974 Protein digestion and absorption SLC37A1 285.5457641 292.356301 278.7352272 0.953409337 -0.06883234 0.840181236 1 1.390103213 1.303159657 54020 solute carrier family 37 member 1 "GO:0005789,GO:0008643,GO:0015760,GO:0016020,GO:0030176,GO:0035435,GO:0061513" endoplasmic reticulum membrane|carbohydrate transport|glucose-6-phosphate transport|membrane|integral component of endoplasmic reticulum membrane|phosphate ion transmembrane transport|glucose 6-phosphate:inorganic phosphate antiporter activity SLC37A2 816.3926595 867.7051781 765.080141 0.881728219 -0.181594063 0.470956642 1 11.55384995 10.01688393 219855 solute carrier family 37 member 2 "GO:0005789,GO:0008643,GO:0015760,GO:0030176,GO:0035435,GO:0061513,GO:0070062" endoplasmic reticulum membrane|carbohydrate transport|glucose-6-phosphate transport|integral component of endoplasmic reticulum membrane|phosphate ion transmembrane transport|glucose 6-phosphate:inorganic phosphate antiporter activity|extracellular exosome SLC37A3 915.5898678 872.9072475 958.2724881 1.097794171 0.134607584 0.589400962 1 13.98962627 15.10073935 84255 solute carrier family 37 member 3 "GO:0008643,GO:0015760,GO:0030176,GO:0035435,GO:0061513" carbohydrate transport|glucose-6-phosphate transport|integral component of endoplasmic reticulum membrane|phosphate ion transmembrane transport|glucose 6-phosphate:inorganic phosphate antiporter activity SLC37A4 809.2242332 767.8254454 850.6230211 1.107833852 0.147741529 0.558893622 1 13.74159384 14.96865981 2542 solute carrier family 37 member 4 "GO:0005515,GO:0005783,GO:0005789,GO:0006006,GO:0006094,GO:0008643,GO:0015152,GO:0015760,GO:0016020,GO:0016021,GO:0030176,GO:0035435,GO:0061513" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|glucose metabolic process|gluconeogenesis|carbohydrate transport|glucose-6-phosphate transmembrane transporter activity|glucose-6-phosphate transport|membrane|integral component of membrane|integral component of endoplasmic reticulum membrane|phosphate ion transmembrane transport|glucose 6-phosphate:inorganic phosphate antiporter activity hsa04973 Carbohydrate digestion and absorption SLC38A1 6741.352113 7741.719701 5740.984525 0.741564503 -0.431355907 0.077173592 1 37.40709387 27.27558545 81539 solute carrier family 38 member 1 "GO:0001504,GO:0003333,GO:0005283,GO:0005295,GO:0005515,GO:0005886,GO:0005887,GO:0006814,GO:0006865,GO:0006868,GO:0015171,GO:0015175,GO:0015179,GO:0015186,GO:0015804,GO:0015807,GO:0016021,GO:0016323,GO:0043025,GO:0070062,GO:0098591,GO:0150104,GO:1902475" neurotransmitter uptake|amino acid transmembrane transport|amino acid:sodium symporter activity|neutral amino acid:sodium symporter activity|protein binding|plasma membrane|integral component of plasma membrane|sodium ion transport|amino acid transport|glutamine transport|amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|L-glutamine transmembrane transporter activity|neutral amino acid transport|L-amino acid transport|integral component of membrane|basolateral plasma membrane|neuronal cell body|extracellular exosome|external side of apical plasma membrane|transport across blood-brain barrier|L-alpha-amino acid transmembrane transport "hsa04724,hsa04727" Glutamatergic synapse|GABAergic synapse SLC38A10 1177.185991 1167.344376 1187.027606 1.016861545 0.024123256 0.924412483 1 12.06410222 12.06224126 124565 solute carrier family 38 member 10 "GO:0003333,GO:0005794,GO:0006814,GO:0015171,GO:0016021,GO:0060348" amino acid transmembrane transport|Golgi apparatus|sodium ion transport|amino acid transmembrane transporter activity|integral component of membrane|bone development SLC38A2 9951.638504 10063.92349 9839.353522 0.977685645 -0.032557425 0.897221542 1 112.011074 107.6790904 54407 solute carrier family 38 member 2 "GO:0003333,GO:0005295,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0005903,GO:0006814,GO:0006865,GO:0006868,GO:0007565,GO:0010628,GO:0014047,GO:0015171,GO:0015186,GO:0015194,GO:0015804,GO:0015825,GO:0021987,GO:0030424,GO:0030425,GO:0031460,GO:0032328,GO:0033120,GO:0034198,GO:0042383,GO:0043025,GO:0071260,GO:0080135,GO:0150104,GO:1903841" amino acid transmembrane transport|neutral amino acid:sodium symporter activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|brush border|sodium ion transport|amino acid transport|glutamine transport|female pregnancy|positive regulation of gene expression|glutamate secretion|amino acid transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-serine transmembrane transporter activity|neutral amino acid transport|L-serine transport|cerebral cortex development|axon|dendrite|glycine betaine transport|alanine transport|positive regulation of RNA splicing|cellular response to amino acid starvation|sarcolemma|neuronal cell body|cellular response to mechanical stimulus|regulation of cellular response to stress|transport across blood-brain barrier|cellular response to arsenite(3-) "hsa04724,hsa04727,hsa04974" Glutamatergic synapse|GABAergic synapse|Protein digestion and absorption SLC38A4 43.15263842 47.8590386 38.44623824 0.80332241 -0.315948971 0.639091649 1 0.626170367 0.494599386 55089 solute carrier family 38 member 4 "GO:0003333,GO:0005515,GO:0005886,GO:0005887,GO:0006814,GO:0006865,GO:0015171,GO:0015293" amino acid transmembrane transport|protein binding|plasma membrane|integral component of plasma membrane|sodium ion transport|amino acid transport|amino acid transmembrane transporter activity|symporter activity SLC38A5 3.601819626 6.242483296 0.961155956 0.153970129 -2.699277611 0.237188726 1 0.164032428 0.024833467 92745 solute carrier family 38 member 5 "GO:0003333,GO:0005290,GO:0005886,GO:0005887,GO:0006865,GO:0006867,GO:0006868,GO:0015171,GO:0015182,GO:0015186,GO:0015187,GO:0015194,GO:0015816,GO:0015825,GO:0022858,GO:0022889,GO:0032329,GO:0089709,GO:0150104,GO:1903713,GO:1904557" amino acid transmembrane transport|L-histidine transmembrane transporter activity|plasma membrane|integral component of plasma membrane|amino acid transport|asparagine transport|glutamine transport|amino acid transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|glycine transmembrane transporter activity|L-serine transmembrane transporter activity|glycine transport|L-serine transport|alanine transmembrane transporter activity|serine transmembrane transporter activity|serine transport|L-histidine transmembrane transport|transport across blood-brain barrier|asparagine transmembrane transport|L-alanine transmembrane transport hsa04727 GABAergic synapse SLC38A6 346.0338083 353.7407201 338.3268965 0.956426211 -0.064274427 0.83995221 1 3.86537512 3.635082693 145389 solute carrier family 38 member 6 "GO:0003333,GO:0005515,GO:0005886,GO:0005887,GO:0006814,GO:0006868,GO:0015171,GO:0015186" amino acid transmembrane transport|protein binding|plasma membrane|integral component of plasma membrane|sodium ion transport|glutamine transport|amino acid transmembrane transporter activity|L-glutamine transmembrane transporter activity SLC38A7 490.7110886 594.076327 387.3458503 0.652013609 -0.617026017 0.024563428 0.86041596 7.350976514 4.712733425 55238 solute carrier family 38 member 7 "GO:0003333,GO:0005290,GO:0005313,GO:0005515,GO:0006814,GO:0006867,GO:0006868,GO:0015171,GO:0015179,GO:0015180,GO:0015182,GO:0015183,GO:0015186,GO:0015190,GO:0015191,GO:0015194,GO:0015803,GO:0015808,GO:0015813,GO:0015821,GO:0015825,GO:0016021,GO:0030424,GO:0043025,GO:0070778,GO:0089709" amino acid transmembrane transport|L-histidine transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding|sodium ion transport|asparagine transport|glutamine transport|amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-aspartate transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-leucine transmembrane transporter activity|L-methionine transmembrane transporter activity|L-serine transmembrane transporter activity|branched-chain amino acid transport|L-alanine transport|L-glutamate transmembrane transport|methionine transport|L-serine transport|integral component of membrane|axon|neuronal cell body|L-aspartate transmembrane transport|L-histidine transmembrane transport SLC38A9 419.6459129 444.2567279 395.0350979 0.889204537 -0.169412786 0.556842793 1 7.002116083 6.122124466 153129 solute carrier family 38 member 9 "GO:0003333,GO:0005515,GO:0005764,GO:0005765,GO:0005770,GO:0007050,GO:0015171,GO:0015190,GO:0015803,GO:0015804,GO:0016241,GO:0032008,GO:0046872,GO:0061459,GO:0071230,GO:0071986,GO:1903400,GO:1905103" amino acid transmembrane transport|protein binding|lysosome|lysosomal membrane|late endosome|cell cycle arrest|amino acid transmembrane transporter activity|L-leucine transmembrane transporter activity|branched-chain amino acid transport|neutral amino acid transport|regulation of macroautophagy|positive regulation of TOR signaling|metal ion binding|L-arginine transmembrane transporter activity|cellular response to amino acid stimulus|Ragulator complex|L-arginine transmembrane transport|integral component of lysosomal membrane hsa04150 mTOR signaling pathway SLC39A1 3380.573428 3310.596975 3450.549882 1.042274221 0.059734898 0.802133047 1 58.46475047 59.91661574 27173 solute carrier family 39 member 1 "GO:0001701,GO:0005102,GO:0005385,GO:0005515,GO:0005789,GO:0005886,GO:0006812,GO:0016020,GO:0016021,GO:0022890,GO:0048701,GO:0060173,GO:0071577" in utero embryonic development|signaling receptor binding|zinc ion transmembrane transporter activity|protein binding|endoplasmic reticulum membrane|plasma membrane|cation transport|membrane|integral component of membrane|inorganic cation transmembrane transporter activity|embryonic cranial skeleton morphogenesis|limb development|zinc ion transmembrane transport SLC39A10 1406.241206 1515.883027 1296.599385 0.855342636 -0.225425639 0.346841904 1 7.329216441 6.164088233 57181 solute carrier family 39 member 10 "GO:0002903,GO:0005385,GO:0005887,GO:0006882,GO:0030890,GO:0050861,GO:0071578,GO:1903615" negative regulation of B cell apoptotic process|zinc ion transmembrane transporter activity|integral component of plasma membrane|cellular zinc ion homeostasis|positive regulation of B cell proliferation|positive regulation of B cell receptor signaling pathway|zinc ion import across plasma membrane|positive regulation of protein tyrosine phosphatase activity SLC39A11 267.7002123 252.8205735 282.5798511 1.117709082 0.160544731 0.630836876 1 1.586241399 1.743288393 201266 solute carrier family 39 member 11 "GO:0005385,GO:0005634,GO:0005737,GO:0005794,GO:0005886,GO:0016020,GO:0016021,GO:0071577" zinc ion transmembrane transporter activity|nucleus|cytoplasm|Golgi apparatus|plasma membrane|membrane|integral component of membrane|zinc ion transmembrane transport SLC39A13 1041.322661 918.6854584 1163.959863 1.266984094 0.341398412 0.163465774 1 16.81363321 20.94613557 91252 solute carrier family 39 member 13 "GO:0005385,GO:0005515,GO:0005783,GO:0005794,GO:0006882,GO:0010043,GO:0016021,GO:0030173,GO:0042803,GO:0048471,GO:0061448,GO:0071577" zinc ion transmembrane transporter activity|protein binding|endoplasmic reticulum|Golgi apparatus|cellular zinc ion homeostasis|response to zinc ion|integral component of membrane|integral component of Golgi membrane|protein homodimerization activity|perinuclear region of cytoplasm|connective tissue development|zinc ion transmembrane transport SLC39A14 3436.322432 3802.712741 3069.932123 0.807300559 -0.308822203 0.193099193 1 33.51119384 26.60090009 23516 solute carrier family 39 member 14 "GO:0002062,GO:0005381,GO:0005384,GO:0005385,GO:0005765,GO:0005886,GO:0005887,GO:0006094,GO:0006882,GO:0008286,GO:0010817,GO:0015086,GO:0015093,GO:0015296,GO:0015698,GO:0016021,GO:0016323,GO:0016324,GO:0031901,GO:0031902,GO:0032869,GO:0033212,GO:0034755,GO:0045745,GO:0051344,GO:0055071,GO:0070574,GO:0071333,GO:0071421,GO:0071577,GO:0071578,GO:0098739" chondrocyte differentiation|iron ion transmembrane transporter activity|manganese ion transmembrane transporter activity|zinc ion transmembrane transporter activity|lysosomal membrane|plasma membrane|integral component of plasma membrane|gluconeogenesis|cellular zinc ion homeostasis|insulin receptor signaling pathway|regulation of hormone levels|cadmium ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|anion:cation symporter activity|inorganic anion transport|integral component of membrane|basolateral plasma membrane|apical plasma membrane|early endosome membrane|late endosome membrane|cellular response to insulin stimulus|iron import into cell|iron ion transmembrane transport|positive regulation of G protein-coupled receptor signaling pathway|negative regulation of cyclic-nucleotide phosphodiesterase activity|manganese ion homeostasis|cadmium ion transmembrane transport|cellular response to glucose stimulus|manganese ion transmembrane transport|zinc ion transmembrane transport|zinc ion import across plasma membrane|import across plasma membrane hsa04216 Ferroptosis SLC39A3 333.0236044 340.2153396 325.8318691 0.957722451 -0.062320472 0.847187436 1 4.598953239 4.33081708 29985 solute carrier family 39 member 3 "GO:0005385,GO:0005886,GO:0016020,GO:0016021,GO:0071577" zinc ion transmembrane transporter activity|plasma membrane|membrane|integral component of membrane|zinc ion transmembrane transport SLC39A4 291.4567388 233.0527097 349.860768 1.501208754 0.586124608 0.064924625 1 4.977028725 7.346532669 55630 solute carrier family 39 member 4 "GO:0005385,GO:0005886,GO:0005887,GO:0006882,GO:0016324,GO:0031410,GO:0034224,GO:0055038,GO:0071578" zinc ion transmembrane transporter activity|plasma membrane|integral component of plasma membrane|cellular zinc ion homeostasis|apical plasma membrane|cytoplasmic vesicle|cellular response to zinc ion starvation|recycling endosome membrane|zinc ion import across plasma membrane hsa04978 Mineral absorption SLC39A6 2366.895963 2461.619246 2272.17268 0.923039858 -0.115535148 0.625838615 1 27.08144608 24.57895895 25800 solute carrier family 39 member 6 "GO:0005385,GO:0005783,GO:0005886,GO:0005887,GO:0006882,GO:0009986,GO:0031258,GO:0071577,GO:0071578" zinc ion transmembrane transporter activity|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|cellular zinc ion homeostasis|cell surface|lamellipodium membrane|zinc ion transmembrane transport|zinc ion import across plasma membrane SLC39A7 2205.180801 2165.10129 2245.260313 1.037023221 0.052448199 0.826072516 1 62.72935752 63.9632466 7922 solute carrier family 39 member 7 "GO:0005385,GO:0005515,GO:0005654,GO:0005783,GO:0005789,GO:0005794,GO:0006882,GO:0016020,GO:0016021,GO:0071577" zinc ion transmembrane transporter activity|protein binding|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cellular zinc ion homeostasis|membrane|integral component of membrane|zinc ion transmembrane transport SLC39A8 567.573997 568.0659799 567.082014 0.998267867 -0.002501107 1 1 4.719277286 4.632268944 64116 solute carrier family 39 member 8 "GO:0005381,GO:0005384,GO:0005385,GO:0005765,GO:0005886,GO:0005887,GO:0006351,GO:0006355,GO:0006487,GO:0006525,GO:0006824,GO:0006829,GO:0006876,GO:0006882,GO:0015086,GO:0015087,GO:0015106,GO:0015296,GO:0015698,GO:0015701,GO:0016323,GO:0016324,GO:0030026,GO:0030198,GO:0031090,GO:0042391,GO:0061757,GO:0070574,GO:0071421,GO:0071577,GO:0071578,GO:0097079,GO:0097080,GO:0098711,GO:0140412,GO:1990079,GO:1990540" "iron ion transmembrane transporter activity|manganese ion transmembrane transporter activity|zinc ion transmembrane transporter activity|lysosomal membrane|plasma membrane|integral component of plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|protein N-linked glycosylation|arginine metabolic process|cobalt ion transport|zinc ion transport|cellular cadmium ion homeostasis|cellular zinc ion homeostasis|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|bicarbonate transmembrane transporter activity|anion:cation symporter activity|inorganic anion transport|bicarbonate transport|basolateral plasma membrane|apical plasma membrane|cellular manganese ion homeostasis|extracellular matrix organization|organelle membrane|regulation of membrane potential|leukocyte adhesion to arterial endothelial cell|cadmium ion transmembrane transport|manganese ion transmembrane transport|zinc ion transmembrane transport|zinc ion import across plasma membrane|selenite:proton symporter activity|plasma membrane selenite transport|iron ion import across plasma membrane|zinc:bicarbonate symporter activity|cartilage homeostasis|mitochondrial manganese ion transmembrane transport" hsa04216 Ferroptosis SLC39A9 1323.713199 1090.353749 1557.072649 1.428043559 0.514039986 0.032616894 0.920517339 10.35780983 14.5438895 55334 solute carrier family 39 member 9 "GO:0005515,GO:0006829,GO:0016021,GO:0046873,GO:0055085" protein binding|zinc ion transport|integral component of membrane|metal ion transmembrane transporter activity|transmembrane transport SLC3A2 4684.686227 5337.323218 4032.049235 0.755444081 -0.404603125 0.091245129 1 116.7389879 86.71404101 6520 solute carrier family 3 member 2 "GO:0003723,GO:0003725,GO:0003824,GO:0005432,GO:0005515,GO:0005654,GO:0005765,GO:0005886,GO:0005975,GO:0006816,GO:0006865,GO:0009925,GO:0009986,GO:0015173,GO:0015175,GO:0015180,GO:0015190,GO:0015823,GO:0015827,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0030054,GO:0035725,GO:0042470,GO:0043330,GO:0045296,GO:0050900,GO:0070062,GO:0098713,GO:1902475,GO:1903801,GO:1904273,GO:1990184" RNA binding|double-stranded RNA binding|catalytic activity|calcium:sodium antiporter activity|protein binding|nucleoplasm|lysosomal membrane|plasma membrane|carbohydrate metabolic process|calcium ion transport|amino acid transport|basal plasma membrane|cell surface|aromatic amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-alanine transmembrane transporter activity|L-leucine transmembrane transporter activity|phenylalanine transport|tryptophan transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|cell junction|sodium ion transmembrane transport|melanosome|response to exogenous dsRNA|cadherin binding|leukocyte migration|extracellular exosome|leucine import across plasma membrane|L-alpha-amino acid transmembrane transport|L-leucine import across plasma membrane|L-alanine import across plasma membrane|amino acid transport complex "hsa04150,hsa04216,hsa04974" mTOR signaling pathway|Ferroptosis|Protein digestion and absorption SLC40A1 72.33391693 82.19269673 62.47513714 0.760105698 -0.395728045 0.45894813 1 1.21711242 0.90965322 30061 solute carrier family 40 member 1 "GO:0005381,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006879,GO:0015093,GO:0016021,GO:0016323,GO:0017046,GO:0034755,GO:0055072,GO:0060586,GO:0072511,GO:1903988" iron ion transmembrane transporter activity|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|integral component of plasma membrane|cellular iron ion homeostasis|ferrous iron transmembrane transporter activity|integral component of membrane|basolateral plasma membrane|peptide hormone binding|iron ion transmembrane transport|iron ion homeostasis|multicellular organismal iron ion homeostasis|divalent inorganic cation transport|iron ion export across plasma membrane "hsa04216,hsa04978" Ferroptosis|Mineral absorption SLC41A1 1523.268875 1598.075724 1448.462026 0.906378843 -0.141813909 0.55316297 1 16.78204727 14.9563589 254428 solute carrier family 41 member 1 "GO:0005515,GO:0005886,GO:0010961,GO:0015095,GO:0015693,GO:0016021,GO:0016323,GO:0022857,GO:0032991,GO:0035725,GO:0061768,GO:0070838,GO:0071286,GO:0072509,GO:1903830" protein binding|plasma membrane|cellular magnesium ion homeostasis|magnesium ion transmembrane transporter activity|magnesium ion transport|integral component of membrane|basolateral plasma membrane|transmembrane transporter activity|protein-containing complex|sodium ion transmembrane transport|magnesium:sodium antiporter activity|divalent metal ion transport|cellular response to magnesium ion|divalent inorganic cation transmembrane transporter activity|magnesium ion transmembrane transport SLC41A2 553.1962866 569.1063938 537.2861794 0.944087407 -0.08300766 0.761512231 1 2.741664765 2.545058291 84102 solute carrier family 41 member 2 "GO:0005515,GO:0005886,GO:0016021,GO:0070838,GO:0072509,GO:0098655" protein binding|plasma membrane|integral component of membrane|divalent metal ion transport|divalent inorganic cation transmembrane transporter activity|cation transmembrane transport SLC41A3 562.0398046 586.7934298 537.2861794 0.915630871 -0.127161989 0.637082119 1 13.55088138 12.19998085 54946 solute carrier family 41 member 3 "GO:0005515,GO:0005886,GO:0008324,GO:0016021,GO:0098655" protein binding|plasma membrane|cation transmembrane transporter activity|integral component of membrane|cation transmembrane transport SLC43A1 365.7073229 428.6505196 302.7641261 0.706319279 -0.501607619 0.090461079 1 6.736245703 4.678322525 8501 solute carrier family 43 member 1 "GO:0005515,GO:0005886,GO:0005887,GO:0006865,GO:0015171,GO:0015175,GO:0015179,GO:0015804,GO:0015807,GO:0051956,GO:0060358,GO:1902475" protein binding|plasma membrane|integral component of plasma membrane|amino acid transport|amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|neutral amino acid transport|L-amino acid transport|negative regulation of amino acid transport|negative regulation of leucine import|L-alpha-amino acid transmembrane transport SLC43A2 55.99426568 82.19269673 29.79583464 0.362511948 -1.463899548 0.011851613 0.645700407 0.476790561 0.169949994 124935 solute carrier family 43 member 2 "GO:0005515,GO:0005886,GO:0006865,GO:0015171,GO:0015175,GO:0015179,GO:0015804,GO:0015807,GO:0016021,GO:0051956,GO:0060358,GO:1902475" protein binding|plasma membrane|amino acid transport|amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|neutral amino acid transport|L-amino acid transport|integral component of membrane|negative regulation of amino acid transport|negative regulation of leucine import|L-alpha-amino acid transmembrane transport SLC43A3 467.0149271 464.0245917 470.0052625 1.012888694 0.018475645 0.955425599 1 8.74131296 8.70581775 29015 solute carrier family 43 member 3 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021,GO:0022857,GO:0055085" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane|transmembrane transporter activity|transmembrane transport SLC44A1 2544.709201 2562.539393 2526.879008 0.986083966 -0.020217596 0.933567627 1 10.91444674 10.58246405 23446 solute carrier family 44 member 1 "GO:0005654,GO:0005739,GO:0005741,GO:0005829,GO:0005886,GO:0006656,GO:0015220,GO:0015871,GO:0016020,GO:0016021,GO:0022857,GO:0042426,GO:0055085,GO:0070062,GO:0150104" nucleoplasm|mitochondrion|mitochondrial outer membrane|cytosol|plasma membrane|phosphatidylcholine biosynthetic process|choline transmembrane transporter activity|choline transport|membrane|integral component of membrane|transmembrane transporter activity|choline catabolic process|transmembrane transport|extracellular exosome|transport across blood-brain barrier hsa05231 Choline metabolism in cancer SLC44A2 2734.938822 2560.458565 2909.419079 1.136288288 0.184328907 0.436060765 1 37.8943338 42.3383555 57153 solute carrier family 44 member 2 "GO:0005739,GO:0005765,GO:0005886,GO:0006656,GO:0015220,GO:0015871,GO:0016020,GO:0016021,GO:0022857,GO:0035579,GO:0043123,GO:0043312,GO:0055085,GO:0070062" mitochondrion|lysosomal membrane|plasma membrane|phosphatidylcholine biosynthetic process|choline transmembrane transporter activity|choline transport|membrane|integral component of membrane|transmembrane transporter activity|specific granule membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|neutrophil degranulation|transmembrane transport|extracellular exosome hsa05231 Choline metabolism in cancer SLC44A3 78.46757418 66.58648849 90.34865986 1.356861758 0.440273742 0.394130188 1 1.134972376 1.51423079 126969 solute carrier family 44 member 3 "GO:0005515,GO:0005886,GO:0006656,GO:0016020,GO:0016021,GO:0022857,GO:0055085" protein binding|plasma membrane|phosphatidylcholine biosynthetic process|membrane|integral component of membrane|transmembrane transporter activity|transmembrane transport hsa05231 Choline metabolism in cancer SLC44A4 4.562975582 6.242483296 2.883467868 0.461910386 -1.11431511 0.584550016 1 0.123663645 0.056165671 80736 solute carrier family 44 member 4 "GO:0005886,GO:0006656,GO:0008292,GO:0015220,GO:0015871,GO:0016020,GO:0016021,GO:0016324,GO:0022857,GO:0030307,GO:0030974,GO:0032475,GO:0035675,GO:0055085,GO:0061526,GO:0070062,GO:0090422" plasma membrane|phosphatidylcholine biosynthetic process|acetylcholine biosynthetic process|choline transmembrane transporter activity|choline transport|membrane|integral component of membrane|apical plasma membrane|transmembrane transporter activity|positive regulation of cell growth|thiamine pyrophosphate transmembrane transport|otolith formation|neuromast hair cell development|transmembrane transport|acetylcholine secretion|extracellular exosome|thiamine pyrophosphate transmembrane transporter activity hsa05231 Choline metabolism in cancer SLC44A5 137.4987932 165.4258073 109.571779 0.662362063 -0.594308051 0.155775174 1 1.008622335 0.656893871 204962 solute carrier family 44 member 5 "GO:0005515,GO:0005886,GO:0006656,GO:0016020,GO:0016021,GO:0022857,GO:0055085" protein binding|plasma membrane|phosphatidylcholine biosynthetic process|membrane|integral component of membrane|transmembrane transporter activity|transmembrane transport hsa05231 Choline metabolism in cancer SLC45A1 93.31077128 103.0009744 83.62056817 0.811842496 -0.300728234 0.540263563 1 2.202312778 1.758012498 50651 solute carrier family 45 member 1 "GO:0008506,GO:0015770,GO:0016020,GO:0016021,GO:1904659" sucrose:proton symporter activity|sucrose transport|membrane|integral component of membrane|glucose transmembrane transport SLC45A3 312.3191223 339.1749257 285.4633189 0.841640396 -0.248724143 0.426320395 1 5.337995402 4.417493775 85414 solute carrier family 45 member 3 "GO:0005886,GO:0008506,GO:0008645,GO:0010907,GO:0015770,GO:0016020,GO:0016021,GO:0045723,GO:0048713,GO:0051119" plasma membrane|sucrose:proton symporter activity|hexose transmembrane transport|positive regulation of glucose metabolic process|sucrose transport|membrane|integral component of membrane|positive regulation of fatty acid biosynthetic process|regulation of oligodendrocyte differentiation|sugar transmembrane transporter activity "hsa05202,hsa05206" Transcriptional misregulation in cancer|MicroRNAs in cancer SLC45A4 112.1571081 143.5771158 80.7371003 0.562325687 -0.830522144 0.064548213 1 0.552766324 0.305633305 57210 solute carrier family 45 member 4 "GO:0008506,GO:0015770,GO:0016020,GO:0016021" sucrose:proton symporter activity|sucrose transport|membrane|integral component of membrane SLC46A1 278.6440653 325.6495453 231.6385854 0.711312479 -0.491444621 0.128179316 1 2.607158373 1.823471668 113235 solute carrier family 46 member 1 "GO:0005542,GO:0005737,GO:0005886,GO:0006879,GO:0008517,GO:0009986,GO:0015078,GO:0015232,GO:0015350,GO:0015884,GO:0015886,GO:0016021,GO:0016323,GO:0016324,GO:0031526,GO:0046655,GO:0051958,GO:0098829,GO:1902600,GO:1904447" folic acid binding|cytoplasm|plasma membrane|cellular iron ion homeostasis|folic acid transmembrane transporter activity|cell surface|proton transmembrane transporter activity|heme transmembrane transporter activity|methotrexate transmembrane transporter activity|folic acid transport|heme transport|integral component of membrane|basolateral plasma membrane|apical plasma membrane|brush border membrane|folic acid metabolic process|methotrexate transport|intestinal folate absorption|proton transmembrane transport|folate import across plasma membrane "hsa01523,hsa04977,hsa04978" Antifolate resistance|Vitamin digestion and absorption|Mineral absorption SLC47A2 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.035403811 0.010719824 146802 solute carrier family 47 member 2 "GO:0005886,GO:0015297,GO:0016020,GO:0016021,GO:0022857,GO:0042908,GO:0042910,GO:0055085" plasma membrane|antiporter activity|membrane|integral component of membrane|transmembrane transporter activity|xenobiotic transport|xenobiotic transmembrane transporter activity|transmembrane transport SLC48A1 472.7120513 537.8939773 407.5301253 0.757640246 -0.400415126 0.148112546 1 5.233621324 3.89884986 55652 solute carrier family 48 member 1 "GO:0005515,GO:0005765,GO:0005886,GO:0010008,GO:0015232,GO:0015886,GO:0016021,GO:0020037" protein binding|lysosomal membrane|plasma membrane|endosome membrane|heme transmembrane transporter activity|heme transport|integral component of membrane|heme binding SLC49A3 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.031494598 0.019072328 84179 solute carrier family 49 member 3 "GO:0016021,GO:0022857,GO:0055085" integral component of membrane|transmembrane transporter activity|transmembrane transport SLC49A4 299.3139488 313.1645787 285.4633189 0.911544084 -0.133615666 0.678387415 1 5.031010834 4.50924786 84925 solute carrier family 49 member 4 "GO:0005765,GO:0016021,GO:0043231" lysosomal membrane|integral component of membrane|intracellular membrane-bounded organelle SLC4A11 119.4500661 133.172977 105.7271552 0.793908476 -0.332955396 0.454932029 1 1.163588248 0.908324322 83959 solute carrier family 4 member 11 "GO:0005272,GO:0005452,GO:0005886,GO:0006814,GO:0012506,GO:0015106,GO:0015252,GO:0015293,GO:0015301,GO:0015701,GO:0016021,GO:0016323,GO:0016324,GO:0022857,GO:0030003,GO:0035445,GO:0035725,GO:0042044,GO:0046713,GO:0046715,GO:0046983,GO:0050801,GO:0055085,GO:1902600" sodium channel activity|inorganic anion exchanger activity|plasma membrane|sodium ion transport|vesicle membrane|bicarbonate transmembrane transporter activity|proton channel activity|symporter activity|anion:anion antiporter activity|bicarbonate transport|integral component of membrane|basolateral plasma membrane|apical plasma membrane|transmembrane transporter activity|cellular cation homeostasis|borate transmembrane transport|sodium ion transmembrane transport|fluid transport|borate transport|active borate transmembrane transporter activity|protein dimerization activity|ion homeostasis|transmembrane transport|proton transmembrane transport SLC4A1AP 590.4536559 537.8939773 643.0133346 1.195427652 0.25752682 0.329982497 1 9.66545891 11.36101034 22950 solute carrier family 4 member 1 adaptor protein "GO:0003729,GO:0005515,GO:0005654,GO:0005737,GO:0005886,GO:0043231" mRNA binding|protein binding|nucleoplasm|cytoplasm|plasma membrane|intracellular membrane-bounded organelle SLC4A2 2488.074612 2678.025334 2298.123891 0.858141206 -0.220713033 0.350595018 1 24.75256149 20.88575038 6522 solute carrier family 4 member 2 "GO:0005452,GO:0005886,GO:0005925,GO:0006820,GO:0007283,GO:0008509,GO:0015301,GO:0015698,GO:0015701,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0019899,GO:0022857,GO:0048565,GO:0050801,GO:0051453,GO:0055085,GO:0098656" inorganic anion exchanger activity|plasma membrane|focal adhesion|anion transport|spermatogenesis|anion transmembrane transporter activity|anion:anion antiporter activity|inorganic anion transport|bicarbonate transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|enzyme binding|transmembrane transporter activity|digestive tract development|ion homeostasis|regulation of intracellular pH|transmembrane transport|anion transmembrane transport "hsa04970,hsa04971,hsa04972,hsa04976" Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion SLC4A3 571.0223312 557.6618411 584.3828212 1.047916099 0.067523213 0.805033819 1 6.170721028 6.358191498 6508 solute carrier family 4 member 3 "GO:0005452,GO:0005515,GO:0005886,GO:0005887,GO:0009897,GO:0015106,GO:0015301,GO:0015698,GO:0015701,GO:0016020,GO:0022857,GO:0050801,GO:0051453,GO:0055085,GO:0061337,GO:0086001,GO:0098656,GO:0150104" inorganic anion exchanger activity|protein binding|plasma membrane|integral component of plasma membrane|external side of plasma membrane|bicarbonate transmembrane transporter activity|anion:anion antiporter activity|inorganic anion transport|bicarbonate transport|membrane|transmembrane transporter activity|ion homeostasis|regulation of intracellular pH|transmembrane transport|cardiac conduction|cardiac muscle cell action potential|anion transmembrane transport|transport across blood-brain barrier SLC4A4 162.2907032 160.2237379 164.3576685 1.025800987 0.036750864 0.942521465 1 0.739372798 0.745757724 8671 solute carrier family 4 member 4 "GO:0005452,GO:0005515,GO:0005886,GO:0005887,GO:0006814,GO:0008510,GO:0009986,GO:0015293,GO:0015698,GO:0015701,GO:0016020,GO:0016323,GO:0022857,GO:0035725,GO:0036376,GO:0042391,GO:0042802,GO:0044214,GO:0045821,GO:0050801,GO:0051453,GO:0055085,GO:0070062,GO:0098656,GO:0150104" inorganic anion exchanger activity|protein binding|plasma membrane|integral component of plasma membrane|sodium ion transport|sodium:bicarbonate symporter activity|cell surface|symporter activity|inorganic anion transport|bicarbonate transport|membrane|basolateral plasma membrane|transmembrane transporter activity|sodium ion transmembrane transport|sodium ion export across plasma membrane|regulation of membrane potential|identical protein binding|spanning component of plasma membrane|positive regulation of glycolytic process|ion homeostasis|regulation of intracellular pH|transmembrane transport|extracellular exosome|anion transmembrane transport|transport across blood-brain barrier "hsa04964,hsa04972,hsa04976" Proximal tubule bicarbonate reclamation|Pancreatic secretion|Bile secretion SLC4A5 13.411524 11.44455271 15.3784953 1.343739304 0.426253271 0.726340813 1 0.093821005 0.123961345 57835 solute carrier family 4 member 5 "GO:0002064,GO:0003014,GO:0003073,GO:0005452,GO:0005886,GO:0008510,GO:0010468,GO:0015301,GO:0015698,GO:0015701,GO:0016021,GO:0016324,GO:0022857,GO:0033326,GO:0035725,GO:0048311,GO:0050801,GO:0051453,GO:0055085,GO:0060041,GO:0098656" epithelial cell development|renal system process|regulation of systemic arterial blood pressure|inorganic anion exchanger activity|plasma membrane|sodium:bicarbonate symporter activity|regulation of gene expression|anion:anion antiporter activity|inorganic anion transport|bicarbonate transport|integral component of membrane|apical plasma membrane|transmembrane transporter activity|cerebrospinal fluid secretion|sodium ion transmembrane transport|mitochondrion distribution|ion homeostasis|regulation of intracellular pH|transmembrane transport|retina development in camera-type eye|anion transmembrane transport hsa04976 Bile secretion SLC4A7 2855.185269 2903.795146 2806.575392 0.966519761 -0.049128865 0.836764154 1 18.16766823 17.26557741 9497 solute carrier family 4 member 7 "GO:0005452,GO:0005515,GO:0005886,GO:0008510,GO:0015698,GO:0015701,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0022857,GO:0031410,GO:0032420,GO:0035725,GO:0045202,GO:0050801,GO:0051453,GO:0055085,GO:0060117,GO:0098656" inorganic anion exchanger activity|protein binding|plasma membrane|sodium:bicarbonate symporter activity|inorganic anion transport|bicarbonate transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|transmembrane transporter activity|cytoplasmic vesicle|stereocilium|sodium ion transmembrane transport|synapse|ion homeostasis|regulation of intracellular pH|transmembrane transport|auditory receptor cell development|anion transmembrane transport SLC4A8 232.7570284 206.0019488 259.5121081 1.259755598 0.333143867 0.334509711 1 0.778939024 0.964852525 9498 solute carrier family 4 member 8 "GO:0005452,GO:0005886,GO:0008021,GO:0008510,GO:0015081,GO:0015106,GO:0015108,GO:0015301,GO:0015701,GO:0016020,GO:0016021,GO:0022857,GO:0030425,GO:0032279,GO:0032280,GO:0032809,GO:0035725,GO:0042391,GO:0042734,GO:0043005,GO:0043195,GO:0043679,GO:0050801,GO:0050804,GO:0051453,GO:0055085,GO:0097386,GO:0097457,GO:0098793,GO:0098978,GO:0150104,GO:1902476,GO:2000302" inorganic anion exchanger activity|plasma membrane|synaptic vesicle|sodium:bicarbonate symporter activity|sodium ion transmembrane transporter activity|bicarbonate transmembrane transporter activity|chloride transmembrane transporter activity|anion:anion antiporter activity|bicarbonate transport|membrane|integral component of membrane|transmembrane transporter activity|dendrite|asymmetric synapse|symmetric synapse|neuronal cell body membrane|sodium ion transmembrane transport|regulation of membrane potential|presynaptic membrane|neuron projection|terminal bouton|axon terminus|ion homeostasis|modulation of chemical synaptic transmission|regulation of intracellular pH|transmembrane transport|glial cell projection|hippocampal mossy fiber|presynapse|glutamatergic synapse|transport across blood-brain barrier|chloride transmembrane transport|positive regulation of synaptic vesicle exocytosis SLC50A1 653.8050463 649.2182628 658.3918299 1.014130174 0.020242849 0.944073158 1 21.92885156 21.86657536 55974 solute carrier family 50 member 1 "GO:0000139,GO:0005515,GO:0005794,GO:0005886,GO:0008643,GO:0008645,GO:0012505,GO:0016021,GO:0042946,GO:0042947,GO:0051119" Golgi membrane|protein binding|Golgi apparatus|plasma membrane|carbohydrate transport|hexose transmembrane transport|endomembrane system|integral component of membrane|glucoside transport|glucoside transmembrane transporter activity|sugar transmembrane transporter activity SLC52A1 13.85247302 10.40413883 17.30080721 1.662877389 0.733681797 0.488071191 1 0.271648614 0.444159443 55065 solute carrier family 52 member 1 "GO:0001618,GO:0005515,GO:0005886,GO:0005887,GO:0006771,GO:0032217,GO:0032218,GO:0046718" virus receptor activity|protein binding|plasma membrane|integral component of plasma membrane|riboflavin metabolic process|riboflavin transmembrane transporter activity|riboflavin transport|viral entry into host cell SLC52A2 1133.662215 1046.656366 1220.668064 1.166254851 0.221883082 0.36226233 1 24.19147968 27.74131698 79581 solute carrier family 52 member 2 "GO:0001618,GO:0005515,GO:0005886,GO:0005887,GO:0006771,GO:0032217,GO:0032218,GO:0046718,GO:0062124" virus receptor activity|protein binding|plasma membrane|integral component of plasma membrane|riboflavin metabolic process|riboflavin transmembrane transporter activity|riboflavin transport|viral entry into host cell|4-hydroxybutyrate receptor activity SLC52A3 13.33226608 9.363724944 17.30080721 1.847641543 0.88568489 0.401500149 1 0.184809464 0.335747745 113278 solute carrier family 52 member 3 "GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0006771,GO:0007605,GO:0016324,GO:0031965,GO:0032217,GO:0032218,GO:0034605" protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|riboflavin metabolic process|sensory perception of sound|apical plasma membrane|nuclear membrane|riboflavin transmembrane transporter activity|riboflavin transport|cellular response to heat hsa04977 Vitamin digestion and absorption SLC5A12 51.9168985 63.46524684 40.36855015 0.636073318 -0.652735025 0.272519652 1 0.459257435 0.287233144 159963 solute carrier family 5 member 12 "GO:0005343,GO:0005654,GO:0005886,GO:0006811,GO:0006814,GO:0015129,GO:0015293,GO:0016021,GO:0016324,GO:0035873,GO:0070062" organic acid:sodium symporter activity|nucleoplasm|plasma membrane|ion transport|sodium ion transport|lactate transmembrane transporter activity|symporter activity|integral component of membrane|apical plasma membrane|lactate transmembrane transport|extracellular exosome SLC5A3 1405.057982 1371.265497 1438.850466 1.049286567 0.069408741 0.774296221 1 6.327331775 6.52808648 6526 solute carrier family 5 member 3 "GO:0005365,GO:0005367,GO:0005412,GO:0005886,GO:0005887,GO:0006020,GO:0006814,GO:0007422,GO:0015146,GO:0015150,GO:0015166,GO:0015459,GO:0015750,GO:0015756,GO:0015791,GO:0015798,GO:0016021,GO:0043085,GO:0043576,GO:0044325,GO:0048471,GO:0150104,GO:1903428,GO:1904659,GO:1904679,GO:1905477" myo-inositol transmembrane transporter activity|myo-inositol:sodium symporter activity|glucose:sodium symporter activity|plasma membrane|integral component of plasma membrane|inositol metabolic process|sodium ion transport|peripheral nervous system development|pentose transmembrane transporter activity|fucose transmembrane transporter activity|polyol transmembrane transporter activity|potassium channel regulator activity|pentose transmembrane transport|fucose transmembrane transport|polyol transport|myo-inositol transport|integral component of membrane|positive regulation of catalytic activity|regulation of respiratory gaseous exchange|ion channel binding|perinuclear region of cytoplasm|transport across blood-brain barrier|positive regulation of reactive oxygen species biosynthetic process|glucose transmembrane transport|myo-inositol import across plasma membrane|positive regulation of protein localization to membrane SLC5A4 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.064190725 0.097180679 6527 solute carrier family 5 member 4 "GO:0005412,GO:0005515,GO:0005886,GO:0006814,GO:0016021,GO:1904659" glucose:sodium symporter activity|protein binding|plasma membrane|sodium ion transport|integral component of membrane|glucose transmembrane transport SLC5A6 281.4136767 310.043337 252.7840164 0.815318332 -0.294564641 0.362739338 1 4.79190358 3.841549705 8884 solute carrier family 5 member 6 "GO:0005886,GO:0005887,GO:0006768,GO:0006814,GO:0008523,GO:0009925,GO:0012506,GO:0015225,GO:0015233,GO:0015293,GO:0015878,GO:0015887,GO:0015939,GO:0016020,GO:0016323,GO:0016324,GO:0031526,GO:0055085,GO:0150104,GO:1905135" plasma membrane|integral component of plasma membrane|biotin metabolic process|sodium ion transport|sodium-dependent multivitamin transmembrane transporter activity|basal plasma membrane|vesicle membrane|biotin transmembrane transporter activity|pantothenate transmembrane transporter activity|symporter activity|biotin transport|pantothenate transmembrane transport|pantothenate metabolic process|membrane|basolateral plasma membrane|apical plasma membrane|brush border membrane|transmembrane transport|transport across blood-brain barrier|biotin import across plasma membrane hsa04977 Vitamin digestion and absorption SLC66A1 275.205792 311.0837509 239.327833 0.769335693 -0.378314852 0.244291491 1 2.703463286 2.045066979 54896 solute carrier family 66 member 1 "GO:0005765,GO:0015174,GO:0015181,GO:0015189,GO:0015809,GO:0015819,GO:0016021,GO:0031301,GO:0043231,GO:0055085,GO:0080144,GO:1903401,GO:1903826" lysosomal membrane|basic amino acid transmembrane transporter activity|arginine transmembrane transporter activity|L-lysine transmembrane transporter activity|arginine transport|lysine transport|integral component of membrane|integral component of organelle membrane|intracellular membrane-bounded organelle|transmembrane transport|amino acid homeostasis|L-lysine transmembrane transport|arginine transmembrane transport SLC66A2 705.4250348 654.4203322 756.4297374 1.1558775 0.208988509 0.415640124 1 8.144871818 9.256935599 80148 solute carrier family 66 member 2 "GO:0005515,GO:0005768,GO:0005802,GO:0005829,GO:0016021,GO:0042147,GO:0045332" "protein binding|endosome|trans-Golgi network|cytosol|integral component of membrane|retrograde transport, endosome to Golgi|phospholipid translocation" SLC66A3 492.1880355 506.6815608 477.6945101 0.942790397 -0.08499103 0.762617188 1 15.74878489 14.59934529 130814 solute carrier family 66 member 3 GO:0016021 integral component of membrane SLC6A16 48.95920312 48.89945248 49.01895376 1.002443816 0.00352138 1 1 0.70455559 0.694458799 28968 solute carrier family 6 member 16 "GO:0005326,GO:0005886,GO:0006836,GO:0015293,GO:0016021,GO:0035725" neurotransmitter transmembrane transporter activity|plasma membrane|neurotransmitter transport|symporter activity|integral component of membrane|sodium ion transmembrane transport SLC6A6 1323.914531 1385.831292 1261.99777 0.910643148 -0.135042276 0.575641922 1 10.8001269 9.670485121 6533 solute carrier family 6 member 6 "GO:0005368,GO:0005369,GO:0005886,GO:0005887,GO:0006836,GO:0006865,GO:0010940,GO:0015171,GO:0015185,GO:0015734,GO:0016021,GO:0016323,GO:0016324,GO:0022858,GO:0030425,GO:0031528,GO:0032328,GO:0035725,GO:0043025,GO:0045597,GO:0051939,GO:0071705,GO:0089718,GO:0098739,GO:0098797,GO:0150104" taurine transmembrane transporter activity|taurine:sodium symporter activity|plasma membrane|integral component of plasma membrane|neurotransmitter transport|amino acid transport|positive regulation of necrotic cell death|amino acid transmembrane transporter activity|gamma-aminobutyric acid transmembrane transporter activity|taurine transport|integral component of membrane|basolateral plasma membrane|apical plasma membrane|alanine transmembrane transporter activity|dendrite|microvillus membrane|alanine transport|sodium ion transmembrane transport|neuronal cell body|positive regulation of cell differentiation|gamma-aminobutyric acid import|nitrogen compound transport|amino acid import across plasma membrane|import across plasma membrane|plasma membrane protein complex|transport across blood-brain barrier SLC6A7 2.601034707 5.202069413 0 0 #NAME? 0.147074026 1 0.069702456 0 6534 solute carrier family 6 member 7 "GO:0005298,GO:0005886,GO:0005887,GO:0006836,GO:0015193,GO:0015824,GO:0016020,GO:0035524,GO:0035725" proline:sodium symporter activity|plasma membrane|integral component of plasma membrane|neurotransmitter transport|L-proline transmembrane transporter activity|proline transport|membrane|proline transmembrane transport|sodium ion transmembrane transport hsa04721 Synaptic vesicle cycle SLC6A8 2083.667572 2381.507377 1785.827766 0.749872868 -0.415282071 0.079181787 1 31.57681285 23.28236597 6535 solute carrier family 6 member 8 "GO:0003674,GO:0005308,GO:0005309,GO:0005886,GO:0005887,GO:0006600,GO:0006836,GO:0006936,GO:0015881,GO:0016021,GO:0035725,GO:0071705" molecular_function|creatine transmembrane transporter activity|creatine:sodium symporter activity|plasma membrane|integral component of plasma membrane|creatine metabolic process|neurotransmitter transport|muscle contraction|creatine transmembrane transport|integral component of membrane|sodium ion transmembrane transport|nitrogen compound transport SLC6A9 109.7491877 156.0620824 63.4362931 0.40648114 -1.298739681 0.004479948 0.412329403 2.295052771 0.91728492 6536 solute carrier family 6 member 9 "GO:0005768,GO:0005886,GO:0005887,GO:0006836,GO:0009925,GO:0014069,GO:0015187,GO:0015375,GO:0015816,GO:0016020,GO:0016323,GO:0016324,GO:0016328,GO:0030285,GO:0031045,GO:0035725,GO:0046985,GO:0070455,GO:0098686,GO:0098688,GO:0099055,GO:0099056,GO:0150104,GO:1903804,GO:1904256,GO:1904440,GO:1904782" endosome|plasma membrane|integral component of plasma membrane|neurotransmitter transport|basal plasma membrane|postsynaptic density|glycine transmembrane transporter activity|glycine:sodium symporter activity|glycine transport|membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|integral component of synaptic vesicle membrane|dense core granule|sodium ion transmembrane transport|positive regulation of hemoglobin biosynthetic process|positive regulation of heme biosynthetic process|hippocampal mossy fiber to CA3 synapse|parallel fiber to Purkinje cell synapse|integral component of postsynaptic membrane|integral component of presynaptic membrane|transport across blood-brain barrier|glycine import across plasma membrane|positive regulation of iron ion transmembrane transporter activity|positive regulation of iron ion import across plasma membrane|negative regulation of NMDA glutamate receptor activity hsa04721 Synaptic vesicle cycle SLC7A1 2842.405965 3211.757656 2473.054275 0.770000274 -0.377069136 0.111078131 1 23.11606246 17.501526 6541 solute carrier family 7 member 1 "GO:0000064,GO:0005290,GO:0005515,GO:0005886,GO:0005887,GO:0006865,GO:0009925,GO:0015171,GO:0015174,GO:0015181,GO:0015189,GO:0015807,GO:0015819,GO:0015822,GO:0016020,GO:0016323,GO:0016324,GO:0032991,GO:0042102,GO:0061459,GO:0089718,GO:0097638,GO:0150104,GO:1903352,GO:1903401,GO:1903810,GO:1903826,GO:1990822" L-ornithine transmembrane transporter activity|L-histidine transmembrane transporter activity|protein binding|plasma membrane|integral component of plasma membrane|amino acid transport|basal plasma membrane|amino acid transmembrane transporter activity|basic amino acid transmembrane transporter activity|arginine transmembrane transporter activity|L-lysine transmembrane transporter activity|L-amino acid transport|lysine transport|ornithine transport|membrane|basolateral plasma membrane|apical plasma membrane|protein-containing complex|positive regulation of T cell proliferation|L-arginine transmembrane transporter activity|amino acid import across plasma membrane|L-arginine import across plasma membrane|transport across blood-brain barrier|L-ornithine transmembrane transport|L-lysine transmembrane transport|L-histidine import across plasma membrane|arginine transmembrane transport|basic amino acid transmembrane transport hsa05206 MicroRNAs in cancer SLC7A11 4488.263197 5403.909706 3572.616688 0.661117021 -0.597022436 0.012710752 0.667587345 29.6034417 19.24383934 23657 solute carrier family 7 member 11 "GO:0003333,GO:0005515,GO:0005791,GO:0005856,GO:0005886,GO:0006749,GO:0006865,GO:0008542,GO:0009636,GO:0009986,GO:0014070,GO:0015179,GO:0015327,GO:0016021,GO:0021591,GO:0021756,GO:0030534,GO:0031526,GO:0033029,GO:0034599,GO:0034775,GO:0035094,GO:0042127,GO:0045177,GO:0048021,GO:0048286,GO:0050804,GO:0050807,GO:0050900,GO:0051223,GO:0051775,GO:0060173,GO:0070306,GO:0070527,GO:0090461,GO:0097449,GO:0098712,GO:0140206,GO:1901494,GO:1903204,GO:1903786,GO:1904717,GO:2000211" amino acid transmembrane transport|protein binding|rough endoplasmic reticulum|cytoskeleton|plasma membrane|glutathione metabolic process|amino acid transport|visual learning|response to toxic substance|cell surface|response to organic cyclic compound|L-amino acid transmembrane transporter activity|cystine:glutamate antiporter activity|integral component of membrane|ventricular system development|striatum development|adult behavior|brush border membrane|regulation of neutrophil apoptotic process|cellular response to oxidative stress|glutathione transmembrane transport|response to nicotine|regulation of cell population proliferation|apical part of cell|regulation of melanin biosynthetic process|lung alveolus development|modulation of chemical synaptic transmission|regulation of synapse organization|leukocyte migration|regulation of protein transport|response to redox state|limb development|lens fiber cell differentiation|platelet aggregation|glutamate homeostasis|astrocyte projection|L-glutamate import across plasma membrane|dipeptide import across plasma membrane|regulation of cysteine metabolic process|negative regulation of oxidative stress-induced neuron death|regulation of glutathione biosynthetic process|regulation of AMPA glutamate receptor clustering|regulation of glutamate metabolic process hsa04216 Ferroptosis SLC7A2 960.474891 1193.354723 727.5950587 0.609705601 -0.713815296 0.003891103 0.385585724 7.833597576 4.696265274 6542 solute carrier family 7 member 2 "GO:0000064,GO:0005886,GO:0005887,GO:0006865,GO:0015171,GO:0015174,GO:0015181,GO:0015189,GO:0030054,GO:0097638,GO:0150104,GO:1903352,GO:1903401" L-ornithine transmembrane transporter activity|plasma membrane|integral component of plasma membrane|amino acid transport|amino acid transmembrane transporter activity|basic amino acid transmembrane transporter activity|arginine transmembrane transporter activity|L-lysine transmembrane transporter activity|cell junction|L-arginine import across plasma membrane|transport across blood-brain barrier|L-ornithine transmembrane transport|L-lysine transmembrane transport SLC7A5 8510.774564 10389.57303 6631.976096 0.638329994 -0.647625655 0.009212637 0.589887864 103.4849603 64.95217045 8140 solute carrier family 7 member 5 "GO:0002720,GO:0003333,GO:0005515,GO:0005765,GO:0005829,GO:0005886,GO:0009925,GO:0010629,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015190,GO:0015196,GO:0015349,GO:0015804,GO:0015823,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0031528,GO:0032729,GO:0032740,GO:0032753,GO:0042605,GO:0042908,GO:0043231,GO:0050900,GO:0070062,GO:0070327,GO:0089718,GO:0098591,GO:0098713,GO:0150104,GO:1902475,GO:1903801,GO:1904556,GO:1990184" positive regulation of cytokine production involved in immune response|amino acid transmembrane transport|protein binding|lysosomal membrane|cytosol|plasma membrane|basal plasma membrane|negative regulation of gene expression|amino acid transmembrane transporter activity|aromatic amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|L-leucine transmembrane transporter activity|L-tryptophan transmembrane transporter activity|thyroid hormone transmembrane transporter activity|neutral amino acid transport|phenylalanine transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|microvillus membrane|positive regulation of interferon-gamma production|positive regulation of interleukin-17 production|positive regulation of interleukin-4 production|peptide antigen binding|xenobiotic transport|intracellular membrane-bounded organelle|leukocyte migration|extracellular exosome|thyroid hormone transport|amino acid import across plasma membrane|external side of apical plasma membrane|leucine import across plasma membrane|transport across blood-brain barrier|L-alpha-amino acid transmembrane transport|L-leucine import across plasma membrane|L-tryptophan transmembrane transport|amino acid transport complex "hsa04150,hsa05230" mTOR signaling pathway|Central carbon metabolism in cancer SLC7A6 782.9453155 885.3922141 680.4984168 0.768584144 -0.379724882 0.132177573 1 6.975458398 5.271513852 9057 solute carrier family 7 member 6 "GO:0003333,GO:0005515,GO:0005886,GO:0005887,GO:0006865,GO:0015171,GO:0015174,GO:0015179,GO:0015297,GO:0015807,GO:0015822,GO:0016323,GO:0043231,GO:0050900,GO:1902475,GO:1990822" amino acid transmembrane transport|protein binding|plasma membrane|integral component of plasma membrane|amino acid transport|amino acid transmembrane transporter activity|basic amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|antiporter activity|L-amino acid transport|ornithine transport|basolateral plasma membrane|intracellular membrane-bounded organelle|leukocyte migration|L-alpha-amino acid transmembrane transport|basic amino acid transmembrane transport SLC7A6OS 566.1769224 556.6214272 575.7324176 1.034333911 0.048702002 0.861095037 1 6.743669136 6.85848505 84138 solute carrier family 7 member 6 opposite strand "GO:0002244,GO:0005634,GO:0005737,GO:0015031,GO:0032502" hematopoietic progenitor cell differentiation|nucleus|cytoplasm|protein transport|developmental process SLC7A7 11.96979007 11.44455271 12.49502743 1.091788185 0.12669299 0.995605371 1 0.260903351 0.280084597 9056 solute carrier family 7 member 7 "GO:0000821,GO:0003333,GO:0005886,GO:0005887,GO:0006865,GO:0015174,GO:0015179,GO:0015807,GO:0016323,GO:0050900,GO:1902475,GO:1990822" regulation of arginine metabolic process|amino acid transmembrane transport|plasma membrane|integral component of plasma membrane|amino acid transport|basic amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|L-amino acid transport|basolateral plasma membrane|leukocyte migration|L-alpha-amino acid transmembrane transport|basic amino acid transmembrane transport hsa04974 Protein digestion and absorption SLC7A8 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.047620049 0.021628119 23428 solute carrier family 7 member 8 "GO:0003333,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0006865,GO:0009636,GO:0009925,GO:0015101,GO:0015171,GO:0015175,GO:0015179,GO:0015180,GO:0015187,GO:0015190,GO:0015349,GO:0015695,GO:0015804,GO:0015816,GO:0015820,GO:0015827,GO:0015829,GO:0016323,GO:0016324,GO:0019534,GO:0031528,GO:0035524,GO:0042605,GO:0050900,GO:0055065,GO:0070327,GO:0089718,GO:0098713,GO:0150104,GO:1901998,GO:1903801,GO:1904273" amino acid transmembrane transport|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|amino acid transport|response to toxic substance|basal plasma membrane|organic cation transmembrane transporter activity|amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|L-alanine transmembrane transporter activity|glycine transmembrane transporter activity|L-leucine transmembrane transporter activity|thyroid hormone transmembrane transporter activity|organic cation transport|neutral amino acid transport|glycine transport|leucine transport|tryptophan transport|valine transport|basolateral plasma membrane|apical plasma membrane|toxin transmembrane transporter activity|microvillus membrane|proline transmembrane transport|peptide antigen binding|leukocyte migration|metal ion homeostasis|thyroid hormone transport|amino acid import across plasma membrane|leucine import across plasma membrane|transport across blood-brain barrier|toxin transport|L-leucine import across plasma membrane|L-alanine import across plasma membrane hsa04974 Protein digestion and absorption SLC8A1 584.1168235 560.7830827 607.4505642 1.083218419 0.115324176 0.666881421 1 1.159010241 1.234452797 6546 solute carrier family 8 member A1 "GO:0002026,GO:0002027,GO:0002028,GO:0005432,GO:0005509,GO:0005515,GO:0005516,GO:0005654,GO:0005739,GO:0005874,GO:0005886,GO:0005887,GO:0006811,GO:0006874,GO:0006883,GO:0006936,GO:0007584,GO:0008092,GO:0009749,GO:0010468,GO:0010649,GO:0010763,GO:0010881,GO:0010882,GO:0014069,GO:0014704,GO:0014829,GO:0015491,GO:0016020,GO:0021537,GO:0030001,GO:0030018,GO:0030315,GO:0030424,GO:0030425,GO:0030501,GO:0030506,GO:0033198,GO:0035725,GO:0035902,GO:0035994,GO:0036376,GO:0042383,GO:0042493,GO:0042542,GO:0043025,GO:0043197,GO:0043198,GO:0043679,GO:0044325,GO:0044557,GO:0045202,GO:0051481,GO:0055013,GO:0055074,GO:0055119,GO:0060048,GO:0060401,GO:0060402,GO:0070509,GO:0070588,GO:0071313,GO:0071320,GO:0071456,GO:0071901,GO:0071944,GO:0086012,GO:0086064,GO:0098703,GO:0098719,GO:0098735,GO:0098794,GO:0099055,GO:0099566,GO:0099580,GO:1903779,GO:1905060" regulation of the force of heart contraction|regulation of heart rate|regulation of sodium ion transport|calcium:sodium antiporter activity|calcium ion binding|protein binding|calmodulin binding|nucleoplasm|mitochondrion|microtubule|plasma membrane|integral component of plasma membrane|ion transport|cellular calcium ion homeostasis|cellular sodium ion homeostasis|muscle contraction|response to nutrient|cytoskeletal protein binding|response to glucose|regulation of gene expression|regulation of cell communication by electrical coupling|positive regulation of fibroblast migration|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of cardiac muscle contraction by calcium ion signaling|postsynaptic density|intercalated disc|vascular associated smooth muscle contraction|cation:cation antiporter activity|membrane|telencephalon development|metal ion transport|Z disc|T-tubule|axon|dendrite|positive regulation of bone mineralization|ankyrin binding|response to ATP|sodium ion transmembrane transport|response to immobilization stress|response to muscle stretch|sodium ion export across plasma membrane|sarcolemma|response to drug|response to hydrogen peroxide|neuronal cell body|dendritic spine|dendritic shaft|axon terminus|ion channel binding|relaxation of smooth muscle|synapse|negative regulation of cytosolic calcium ion concentration|cardiac muscle cell development|calcium ion homeostasis|relaxation of cardiac muscle|cardiac muscle contraction|cytosolic calcium ion transport|calcium ion transport into cytosol|calcium ion import|calcium ion transmembrane transport|cellular response to caffeine|cellular response to cAMP|cellular response to hypoxia|negative regulation of protein serine/threonine kinase activity|cell periphery|membrane depolarization during cardiac muscle cell action potential|cell communication by electrical coupling involved in cardiac conduction|calcium ion import across plasma membrane|sodium ion import across plasma membrane|positive regulation of the force of heart contraction|postsynapse|integral component of postsynaptic membrane|regulation of postsynaptic cytosolic calcium ion concentration|ion antiporter activity involved in regulation of postsynaptic membrane potential|regulation of cardiac conduction|calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration "hsa04020,hsa04022,hsa04260,hsa04261,hsa04371,hsa04740,hsa04961,hsa04974,hsa04978,hsa05410,hsa05412,hsa05414" Calcium signaling pathway|cGMP-PKG signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Apelin signaling pathway|Olfactory transduction|Endocrine and other factor-regulated calcium reabsorption|Protein digestion and absorption|Mineral absorption|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy SLC8B1 889.4594051 1019.605605 759.3132052 0.744712663 -0.425244206 0.087098304 1 16.03727592 11.7433098 80024 solute carrier family 8 member B1 "GO:0005432,GO:0005743,GO:0005886,GO:0006811,GO:0006812,GO:0006851,GO:0006874,GO:0008324,GO:0015368,GO:0016020,GO:0030061,GO:0032592,GO:0035725,GO:0042593,GO:0042803,GO:0050796,GO:0050896,GO:0051480,GO:0051560,GO:0086036,GO:0086038,GO:0099093,GO:1901623,GO:2001256" calcium:sodium antiporter activity|mitochondrial inner membrane|plasma membrane|ion transport|cation transport|mitochondrial calcium ion transmembrane transport|cellular calcium ion homeostasis|cation transmembrane transporter activity|calcium:cation antiporter activity|membrane|mitochondrial crista|integral component of mitochondrial membrane|sodium ion transmembrane transport|glucose homeostasis|protein homodimerization activity|regulation of insulin secretion|response to stimulus|regulation of cytosolic calcium ion concentration|mitochondrial calcium ion homeostasis|regulation of cardiac muscle cell membrane potential|calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential|calcium export from the mitochondrion|regulation of lymphocyte chemotaxis|regulation of store-operated calcium entry SLC9A1 585.0679186 585.7530159 584.3828212 0.997660798 -0.003378709 0.997221298 1 8.181251476 8.025531954 6548 solute carrier family 9 member A1 "GO:0005515,GO:0005516,GO:0005546,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0005925,GO:0006811,GO:0006883,GO:0006885,GO:0009986,GO:0010447,GO:0010613,GO:0010882,GO:0014704,GO:0015299,GO:0015385,GO:0015386,GO:0016021,GO:0016323,GO:0016324,GO:0016477,GO:0030011,GO:0030027,GO:0030214,GO:0030307,GO:0030315,GO:0030346,GO:0030674,GO:0032869,GO:0035794,GO:0035994,GO:0036376,GO:0043065,GO:0043066,GO:0045121,GO:0045760,GO:0045944,GO:0048306,GO:0048471,GO:0051259,GO:0051453,GO:0051492,GO:0051893,GO:0051930,GO:0055007,GO:0060090,GO:0070062,GO:0070417,GO:0070886,GO:0070997,GO:0071236,GO:0071257,GO:0071260,GO:0071456,GO:0071468,GO:0071805,GO:0071872,GO:0086003,GO:0086036,GO:0086040,GO:0086092,GO:0090533,GO:0098656,GO:0098719,GO:0098735,GO:1902600,GO:1903281" "protein binding|calmodulin binding|phosphatidylinositol-4,5-bisphosphate binding|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|focal adhesion|ion transport|cellular sodium ion homeostasis|regulation of pH|cell surface|response to acidic pH|positive regulation of cardiac muscle hypertrophy|regulation of cardiac muscle contraction by calcium ion signaling|intercalated disc|solute:proton antiporter activity|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|basolateral plasma membrane|apical plasma membrane|cell migration|maintenance of cell polarity|lamellipodium|hyaluronan catabolic process|positive regulation of cell growth|T-tubule|protein phosphatase 2B binding|protein-macromolecule adaptor activity|cellular response to insulin stimulus|positive regulation of mitochondrial membrane permeability|response to muscle stretch|sodium ion export across plasma membrane|positive regulation of apoptotic process|negative regulation of apoptotic process|membrane raft|positive regulation of action potential|positive regulation of transcription by RNA polymerase II|calcium-dependent protein binding|perinuclear region of cytoplasm|protein complex oligomerization|regulation of intracellular pH|regulation of stress fiber assembly|regulation of focal adhesion assembly|regulation of sensory perception of pain|cardiac muscle cell differentiation|molecular adaptor activity|extracellular exosome|cellular response to cold|positive regulation of calcineurin-NFAT signaling cascade|neuron death|cellular response to antibiotic|cellular response to electrical stimulus|cellular response to mechanical stimulus|cellular response to hypoxia|cellular response to acidic pH|potassium ion transmembrane transport|cellular response to epinephrine stimulus|cardiac muscle cell contraction|regulation of cardiac muscle cell membrane potential|sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential|regulation of the force of heart contraction by cardiac conduction|cation-transporting ATPase complex|anion transmembrane transport|sodium ion import across plasma membrane|positive regulation of the force of heart contraction|proton transmembrane transport|positive regulation of calcium:sodium antiporter activity" "hsa04024,hsa04260,hsa04261,hsa04371,hsa04810,hsa04919,hsa04970,hsa04971,hsa04972,hsa04976,hsa05205" cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Apelin signaling pathway|Regulation of actin cytoskeleton|Thyroid hormone signaling pathway|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Proteoglycans in cancer SLC9A2 8.125166245 11.44455271 4.80577978 0.419918533 -1.251818634 0.34524811 1 0.109047446 0.045024792 6549 solute carrier family 9 member A2 "GO:0005886,GO:0006811,GO:0008104,GO:0015385,GO:0015386,GO:0016021,GO:0051453,GO:0071805,GO:0098656,GO:0098719,GO:1902600" plasma membrane|ion transport|protein localization|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|regulation of intracellular pH|potassium ion transmembrane transport|anion transmembrane transport|sodium ion import across plasma membrane|proton transmembrane transport SLC9A3 260.5311716 253.8609874 267.2013558 1.052549896 0.073888625 0.8337359 1 2.438900867 2.5241085 6550 solute carrier family 9 member A3 "GO:0005515,GO:0005886,GO:0005903,GO:0006811,GO:0009986,GO:0015385,GO:0015386,GO:0016021,GO:0016324,GO:0030165,GO:0031526,GO:0051453,GO:0070062,GO:0071805,GO:0098656,GO:0098719,GO:1902600" protein binding|plasma membrane|brush border|ion transport|cell surface|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|apical plasma membrane|PDZ domain binding|brush border membrane|regulation of intracellular pH|extracellular exosome|potassium ion transmembrane transport|anion transmembrane transport|sodium ion import across plasma membrane|proton transmembrane transport "hsa04964,hsa04974,hsa04976,hsa04978" Proximal tubule bicarbonate reclamation|Protein digestion and absorption|Bile secretion|Mineral absorption SLC9A3R1 1284.086924 1236.011693 1332.162155 1.0777909 0.108077311 0.655598306 1 33.09767804 35.07544731 9368 SLC9A3 regulator 1 "GO:0001726,GO:0002009,GO:0003096,GO:0005102,GO:0005515,GO:0005634,GO:0005737,GO:0005902,GO:0007009,GO:0007097,GO:0007191,GO:0007605,GO:0008013,GO:0008285,GO:0008360,GO:0008361,GO:0010642,GO:0012505,GO:0014067,GO:0015185,GO:0015629,GO:0016020,GO:0016055,GO:0016324,GO:0017081,GO:0019902,GO:0022612,GO:0030033,GO:0030036,GO:0030165,GO:0030175,GO:0030336,GO:0030643,GO:0031526,GO:0031528,GO:0031698,GO:0031799,GO:0031800,GO:0031982,GO:0032415,GO:0032416,GO:0032426,GO:0032782,GO:0034635,GO:0034767,GO:0043495,GO:0043621,GO:0044062,GO:0044782,GO:0044877,GO:0045121,GO:0045159,GO:0045198,GO:0045199,GO:0045859,GO:0045930,GO:0047485,GO:0048471,GO:0050780,GO:0051683,GO:0051898,GO:0051939,GO:0060088,GO:0060158,GO:0065003,GO:0070062,GO:0070293,GO:0070373,GO:0070851,GO:0071944,GO:0072659,GO:0090090,GO:0090660,GO:0097225,GO:0097291,GO:0098739,GO:0098797,GO:0150104,GO:2001244" ruffle|morphogenesis of an epithelium|renal sodium ion transport|signaling receptor binding|protein binding|nucleus|cytoplasm|microvillus|plasma membrane organization|nuclear migration|adenylate cyclase-activating dopamine receptor signaling pathway|sensory perception of sound|beta-catenin binding|negative regulation of cell population proliferation|regulation of cell shape|regulation of cell size|negative regulation of platelet-derived growth factor receptor signaling pathway|endomembrane system|negative regulation of phosphatidylinositol 3-kinase signaling|gamma-aminobutyric acid transmembrane transporter activity|actin cytoskeleton|membrane|Wnt signaling pathway|apical plasma membrane|chloride channel regulator activity|phosphatase binding|gland morphogenesis|microvillus assembly|actin cytoskeleton organization|PDZ domain binding|filopodium|negative regulation of cell migration|cellular phosphate ion homeostasis|brush border membrane|microvillus membrane|beta-2 adrenergic receptor binding|type 2 metabotropic glutamate receptor binding|type 3 metabotropic glutamate receptor binding|vesicle|regulation of sodium:proton antiporter activity|negative regulation of sodium:proton antiporter activity|stereocilium tip|bile acid secretion|glutathione transport|positive regulation of ion transmembrane transport|protein-membrane adaptor activity|protein self-association|regulation of excretion|cilium organization|protein-containing complex binding|membrane raft|myosin II binding|establishment of epithelial cell apical/basal polarity|maintenance of epithelial cell apical/basal polarity|regulation of protein kinase activity|negative regulation of mitotic cell cycle|protein N-terminus binding|perinuclear region of cytoplasm|dopamine receptor binding|establishment of Golgi localization|negative regulation of protein kinase B signaling|gamma-aminobutyric acid import|auditory receptor cell stereocilium organization|phospholipase C-activating dopamine receptor signaling pathway|protein-containing complex assembly|extracellular exosome|renal absorption|negative regulation of ERK1 and ERK2 cascade|growth factor receptor binding|cell periphery|protein localization to plasma membrane|negative regulation of canonical Wnt signaling pathway|cerebrospinal fluid circulation|sperm midpiece|renal phosphate ion absorption|import across plasma membrane|plasma membrane protein complex|transport across blood-brain barrier|positive regulation of intrinsic apoptotic signaling pathway "hsa04530,hsa04928,hsa05130,hsa05165" "Tight junction|Parathyroid hormone synthesis, secretion and action|Pathogenic Escherichia coli infection|Human papillomavirus infection" SLC9A3R2 512.2534237 503.5603192 520.9465281 1.034526567 0.048970694 0.863946263 1 4.776766571 4.858999399 9351 SLC9A3 regulator 2 "GO:0005102,GO:0005515,GO:0005634,GO:0005886,GO:0005925,GO:0008013,GO:0008022,GO:0012505,GO:0016324,GO:0019902,GO:0031799,GO:0031800,GO:0042802,GO:0043495,GO:0045296,GO:0065003,GO:0070062,GO:0072659" signaling receptor binding|protein binding|nucleus|plasma membrane|focal adhesion|beta-catenin binding|protein C-terminus binding|endomembrane system|apical plasma membrane|phosphatase binding|type 2 metabotropic glutamate receptor binding|type 3 metabotropic glutamate receptor binding|identical protein binding|protein-membrane adaptor activity|cadherin binding|protein-containing complex assembly|extracellular exosome|protein localization to plasma membrane hsa04960 Aldosterone-regulated sodium reabsorption SLC9A5 136.7559037 120.6880104 152.823797 1.266271575 0.34058685 0.422071534 1 1.253580634 1.560810978 6553 solute carrier family 9 member A5 "GO:0005886,GO:0006811,GO:0015385,GO:0015386,GO:0016021,GO:0051453,GO:0071805,GO:0098656,GO:0098719,GO:1902600" plasma membrane|ion transport|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|regulation of intracellular pH|potassium ion transmembrane transport|anion transmembrane transport|sodium ion import across plasma membrane|proton transmembrane transport SLC9A6 921.029711 889.5538697 952.5055524 1.070767702 0.098645528 0.693499048 1 9.085905281 9.56609405 10479 solute carrier family 9 member A6 "GO:0005739,GO:0005789,GO:0005886,GO:0006811,GO:0015385,GO:0015386,GO:0016021,GO:0031901,GO:0043231,GO:0048675,GO:0048812,GO:0051453,GO:0055037,GO:0055038,GO:0071805,GO:0097484,GO:0098656,GO:0098719,GO:1902600" mitochondrion|endoplasmic reticulum membrane|plasma membrane|ion transport|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|early endosome membrane|intracellular membrane-bounded organelle|axon extension|neuron projection morphogenesis|regulation of intracellular pH|recycling endosome|recycling endosome membrane|potassium ion transmembrane transport|dendrite extension|anion transmembrane transport|sodium ion import across plasma membrane|proton transmembrane transport hsa04260 Cardiac muscle contraction SLC9A7 3074.299259 2877.784799 3270.813718 1.136573422 0.184690885 0.435699372 1 15.33520575 17.13792674 84679 solute carrier family 9 member A7 "GO:0000139,GO:0005515,GO:0005802,GO:0005886,GO:0006811,GO:0006885,GO:0015385,GO:0015386,GO:0016021,GO:0043231,GO:0051453,GO:0055037,GO:0055038,GO:0071805,GO:0098656,GO:0098719,GO:1902600,GO:1905526" Golgi membrane|protein binding|trans-Golgi network|plasma membrane|ion transport|regulation of pH|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|intracellular membrane-bounded organelle|regulation of intracellular pH|recycling endosome|recycling endosome membrane|potassium ion transmembrane transport|anion transmembrane transport|sodium ion import across plasma membrane|proton transmembrane transport|regulation of Golgi lumen acidification hsa04260 Cardiac muscle contraction SLC9A8 530.1826495 633.6120545 426.7532445 0.673524504 -0.570197661 0.03443587 0.945603463 4.453405877 2.94928578 23315 solute carrier family 9 member A8 "GO:0000139,GO:0005515,GO:0005794,GO:0006811,GO:0015385,GO:0015386,GO:0016021,GO:0035725,GO:0051453,GO:0071805,GO:0098656,GO:1902600" Golgi membrane|protein binding|Golgi apparatus|ion transport|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|sodium ion transmembrane transport|regulation of intracellular pH|potassium ion transmembrane transport|anion transmembrane transport|proton transmembrane transport SLC9A9 38.6292918 42.65696919 34.60161442 0.811159702 -0.301942113 0.672136163 1 0.248339047 0.198071758 285195 solute carrier family 9 member A9 "GO:0005515,GO:0005886,GO:0006811,GO:0015385,GO:0015386,GO:0016021,GO:0031902,GO:0051453,GO:0055037,GO:0071805,GO:0098656,GO:0098719,GO:1902600" protein binding|plasma membrane|ion transport|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|late endosome membrane|regulation of intracellular pH|recycling endosome|potassium ion transmembrane transport|anion transmembrane transport|sodium ion import across plasma membrane|proton transmembrane transport SLC9B1 3.443303773 2.080827765 4.80577978 2.309551929 1.207612985 0.648665767 1 0.052258802 0.118674758 150159 solute carrier family 9 member B1 "GO:0005886,GO:0006814,GO:0007338,GO:0015299,GO:0015672,GO:0016021,GO:0030317,GO:0034220,GO:0051453,GO:0097228,GO:1902600" plasma membrane|sodium ion transport|single fertilization|solute:proton antiporter activity|monovalent inorganic cation transport|integral component of membrane|flagellated sperm motility|ion transmembrane transport|regulation of intracellular pH|sperm principal piece|proton transmembrane transport SLC9B2 162.4391582 189.3553266 135.5229898 0.715707301 -0.482558398 0.220815424 1 1.137499523 0.800493573 133308 solute carrier family 9 member B2 "GO:0005451,GO:0005515,GO:0005743,GO:0005886,GO:0006814,GO:0010008,GO:0010348,GO:0015385,GO:0015672,GO:0016021,GO:0016323,GO:0016324,GO:0030317,GO:0030672,GO:0031966,GO:0034220,GO:0035725,GO:0042802,GO:0061178,GO:0072583,GO:0097228,GO:1902600,GO:2001206" monovalent cation:proton antiporter activity|protein binding|mitochondrial inner membrane|plasma membrane|sodium ion transport|endosome membrane|lithium:proton antiporter activity|sodium:proton antiporter activity|monovalent inorganic cation transport|integral component of membrane|basolateral plasma membrane|apical plasma membrane|flagellated sperm motility|synaptic vesicle membrane|mitochondrial membrane|ion transmembrane transport|sodium ion transmembrane transport|identical protein binding|regulation of insulin secretion involved in cellular response to glucose stimulus|clathrin-dependent endocytosis|sperm principal piece|proton transmembrane transport|positive regulation of osteoclast development SLC9C1 5.003924597 5.202069413 4.80577978 0.923820772 -0.11431511 1 1 0.046071172 0.041849297 285335 solute carrier family 9 member C1 "GO:0005216,GO:0005886,GO:0007275,GO:0007283,GO:0015385,GO:0015386,GO:0016021,GO:0030154,GO:0030317,GO:0031514,GO:0051453,GO:0071805,GO:0098656,GO:0098719,GO:1902600" ion channel activity|plasma membrane|multicellular organism development|spermatogenesis|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|cell differentiation|flagellated sperm motility|motile cilium|regulation of intracellular pH|potassium ion transmembrane transport|anion transmembrane transport|sodium ion import across plasma membrane|proton transmembrane transport SLCO1A2 6.366400604 3.121241648 9.61155956 3.079402572 1.622650484 0.289347527 1 0.012618357 0.038206782 6579 solute carrier organic anion transporter family member 1A2 "GO:0005886,GO:0005887,GO:0008514,GO:0015125,GO:0015347,GO:0015711,GO:0015721,GO:0043252,GO:0055085" plasma membrane|integral component of plasma membrane|organic anion transmembrane transporter activity|bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|organic anion transport|bile acid and bile salt transport|sodium-independent organic anion transport|transmembrane transport hsa04976 Bile secretion SLCO1B3 5.325986721 1.040413883 9.61155956 9.238207717 3.207612985 0.087285241 1 0.017688747 0.160677835 28234 solute carrier organic anion transporter family member 1B3 "GO:0005886,GO:0005887,GO:0008514,GO:0015125,GO:0015347,GO:0015711,GO:0015721,GO:0016323,GO:0043252,GO:0055085" plasma membrane|integral component of plasma membrane|organic anion transmembrane transporter activity|bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|organic anion transport|bile acid and bile salt transport|basolateral plasma membrane|sodium-independent organic anion transport|transmembrane transport hsa04976 Bile secretion SLCO3A1 393.917999 387.0339643 400.8020336 1.035573284 0.050429652 0.870682414 1 3.461587287 3.524741759 28232 solute carrier organic anion transporter family member 3A1 "GO:0001934,GO:0005886,GO:0005887,GO:0015347,GO:0015732,GO:0043252,GO:0051092,GO:0055085,GO:0150104" positive regulation of protein phosphorylation|plasma membrane|integral component of plasma membrane|sodium-independent organic anion transmembrane transporter activity|prostaglandin transport|sodium-independent organic anion transport|positive regulation of NF-kappaB transcription factor activity|transmembrane transport|transport across blood-brain barrier SLCO4A1 5811.137698 5096.987611 6525.287785 1.280224376 0.356396684 0.140647714 1 45.11059054 56.78528152 28231 solute carrier organic anion transporter family member 4A1 "GO:0005515,GO:0005886,GO:0005887,GO:0015347,GO:0015349,GO:0043252,GO:0055085,GO:0070327" protein binding|plasma membrane|integral component of plasma membrane|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity|sodium-independent organic anion transport|transmembrane transport|thyroid hormone transport SLCO5A1 9.046693237 10.40413883 7.689247648 0.739056617 -0.436243205 0.791668951 1 0.050036025 0.036360654 81796 solute carrier organic anion transporter family member 5A1 "GO:0005886,GO:0005887,GO:0015347,GO:0043231,GO:0043252,GO:0055085" plasma membrane|integral component of plasma membrane|sodium-independent organic anion transmembrane transporter activity|intracellular membrane-bounded organelle|sodium-independent organic anion transport|transmembrane transport SLF1 440.5139412 436.9738307 444.0540517 1.016202849 0.023188414 0.943137494 1 1.734897353 1.733506088 84250 SMC5-SMC6 complex localization factor 1 "GO:0000786,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0006281,GO:0006974,GO:0031334,GO:0031625,GO:0034184,GO:0035861,GO:0042405,GO:0044877,GO:1990166,GO:2000781" nucleosome|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|DNA repair|cellular response to DNA damage stimulus|positive regulation of protein-containing complex assembly|ubiquitin protein ligase binding|positive regulation of maintenance of mitotic sister chromatid cohesion|site of double-strand break|nuclear inclusion body|protein-containing complex binding|protein localization to site of double-strand break|positive regulation of double-strand break repair SLF2 3502.677406 3715.317975 3290.036837 0.885533044 -0.175381951 0.460175217 1 17.75586029 15.4602912 55719 SMC5-SMC6 complex localization factor 2 "GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006974,GO:0031334,GO:0031625,GO:0034184,GO:0035861,GO:0043231,GO:0044877,GO:1990166,GO:2000781" chromatin|protein binding|nucleus|nucleoplasm|DNA repair|cellular response to DNA damage stimulus|positive regulation of protein-containing complex assembly|ubiquitin protein ligase binding|positive regulation of maintenance of mitotic sister chromatid cohesion|site of double-strand break|intracellular membrane-bounded organelle|protein-containing complex binding|protein localization to site of double-strand break|positive regulation of double-strand break repair SLFN11 1452.272282 1576.227032 1328.317531 0.842719674 -0.246875288 0.301885308 1 16.17387805 13.40196489 91607 schlafen family member 11 "GO:0000049,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006974,GO:0008156,GO:0010942,GO:0016887,GO:0043111,GO:0051607,GO:0090734,GO:2000134" tRNA binding|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|cellular response to DNA damage stimulus|negative regulation of DNA replication|positive regulation of cell death|ATPase activity|replication fork arrest|defense response to virus|site of DNA damage|negative regulation of G1/S transition of mitotic cell cycle SLFN12 389.3298713 443.216314 335.4434286 0.756839083 -0.401941504 0.167647797 1 4.940192164 3.676364569 55106 schlafen family member 12 GO:0005515 protein binding SLFN13 29.33979437 38.49531366 20.18427508 0.524330708 -0.931451053 0.205754918 1 0.199846706 0.103032317 146857 schlafen family member 13 "GO:0000049,GO:0004521,GO:0005524,GO:0005737,GO:0008270,GO:0016075,GO:0016078,GO:0051607,GO:0090502" "tRNA binding|endoribonuclease activity|ATP binding|cytoplasm|zinc ion binding|rRNA catabolic process|tRNA catabolic process|defense response to virus|RNA phosphodiester bond hydrolysis, endonucleolytic" SLFN5 3318.218522 3906.754129 2729.682915 0.698708653 -0.517237088 0.029361863 0.886365277 19.75331952 13.57086059 162394 schlafen family member 5 "GO:0005524,GO:0005634,GO:0030154" ATP binding|nucleus|cell differentiation SLFNL1 3.522561699 4.161655531 2.883467868 0.692865579 -0.529352609 0.940314863 1 0.040492235 0.027586202 200172 schlafen like 1 GO:0005524 ATP binding SLIRP 435.2527355 374.5489978 495.9564733 1.324143106 0.405059049 0.152174775 1 47.14384816 61.38060033 81892 SRA stem-loop interacting RNA binding protein "GO:0000961,GO:0003723,GO:0005515,GO:0005634,GO:0005739,GO:0070584" negative regulation of mitochondrial RNA catabolic process|RNA binding|protein binding|nucleus|mitochondrion|mitochondrion morphogenesis SLIT2 483.6219202 496.277422 470.9664184 0.948998277 -0.075522627 0.790291446 1 2.581424356 2.408773729 9353 slit guidance ligand 2 "GO:0001657,GO:0001933,GO:0002042,GO:0002689,GO:0003180,GO:0003184,GO:0005095,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005886,GO:0007411,GO:0008045,GO:0008201,GO:0010593,GO:0010596,GO:0014912,GO:0016020,GO:0021834,GO:0021836,GO:0021972,GO:0030308,GO:0030336,GO:0030837,GO:0031290,GO:0032870,GO:0034260,GO:0035385,GO:0042802,GO:0042803,GO:0043065,GO:0043116,GO:0043237,GO:0043394,GO:0048495,GO:0048754,GO:0048846,GO:0050772,GO:0050919,GO:0050929,GO:0051058,GO:0051414,GO:0060412,GO:0061364,GO:0070062,GO:0070100,GO:0071504,GO:0071672,GO:0071676,GO:0090024,GO:0090027,GO:0090260,GO:0090288" ureteric bud development|negative regulation of protein phosphorylation|cell migration involved in sprouting angiogenesis|negative regulation of leukocyte chemotaxis|aortic valve morphogenesis|pulmonary valve morphogenesis|GTPase inhibitor activity|calcium ion binding|protein binding|extracellular region|extracellular space|cytoplasm|plasma membrane|axon guidance|motor neuron axon guidance|heparin binding|negative regulation of lamellipodium assembly|negative regulation of endothelial cell migration|negative regulation of smooth muscle cell migration|membrane|chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|negative regulation of cell growth|negative regulation of cell migration|negative regulation of actin filament polymerization|retinal ganglion cell axon guidance|cellular response to hormone stimulus|negative regulation of GTPase activity|Roundabout signaling pathway|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|negative regulation of vascular permeability|laminin-1 binding|proteoglycan binding|Roundabout binding|branching morphogenesis of an epithelial tube|axon extension involved in axon guidance|positive regulation of axonogenesis|negative chemotaxis|induction of negative chemotaxis|negative regulation of small GTPase mediated signal transduction|response to cortisol|ventricular septum morphogenesis|apoptotic process involved in luteolysis|extracellular exosome|negative regulation of chemokine-mediated signaling pathway|cellular response to heparin|negative regulation of smooth muscle cell chemotaxis|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of monocyte chemotaxis|negative regulation of retinal ganglion cell axon guidance|negative regulation of cellular response to growth factor stimulus hsa04360 Axon guidance SLIT3 2.962725795 2.080827765 3.844623824 1.847641543 0.88568489 0.829811711 1 0.011406117 0.020721764 6586 slit guidance ligand 3 "GO:0003180,GO:0003181,GO:0005509,GO:0005615,GO:0005739,GO:0007411,GO:0008201,GO:0008285,GO:0010629,GO:0021834,GO:0030308,GO:0032870,GO:0035385,GO:0048495,GO:0048846,GO:0050919,GO:0051414,GO:0060412,GO:0061364,GO:0070100" aortic valve morphogenesis|atrioventricular valve morphogenesis|calcium ion binding|extracellular space|mitochondrion|axon guidance|heparin binding|negative regulation of cell population proliferation|negative regulation of gene expression|chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration|negative regulation of cell growth|cellular response to hormone stimulus|Roundabout signaling pathway|Roundabout binding|axon extension involved in axon guidance|negative chemotaxis|response to cortisol|ventricular septum morphogenesis|apoptotic process involved in luteolysis|negative regulation of chemokine-mediated signaling pathway hsa04360 Axon guidance SLITRK3 27.02119282 28.09117483 25.95121081 0.923820772 -0.11431511 0.930963103 1 0.283237176 0.257281854 22865 SLIT and NTRK like family member 3 "GO:0005515,GO:0005886,GO:0007409,GO:0051965,GO:0098982,GO:0099060,GO:0099061,GO:0099560,GO:1905606" protein binding|plasma membrane|axonogenesis|positive regulation of synapse assembly|GABA-ergic synapse|integral component of postsynaptic specialization membrane|integral component of postsynaptic density membrane|synaptic membrane adhesion|regulation of presynapse assembly SLITRK4 467.5250732 490.0349387 445.0152076 0.908129548 -0.139029976 0.621056431 1 2.775659524 2.478478625 139065 SLIT and NTRK like family member 4 "GO:0005886,GO:0007409,GO:0016021,GO:0050807,GO:0098978,GO:1905606" plasma membrane|axonogenesis|integral component of membrane|regulation of synapse organization|glutamatergic synapse|regulation of presynapse assembly SLITRK5 6.564545421 8.323311061 4.80577978 0.577387982 -0.792387015 0.636893371 1 0.078438957 0.044531849 26050 SLIT and NTRK like family member 5 "GO:0005515,GO:0005886,GO:0007268,GO:0007409,GO:0007625,GO:0009410,GO:0016021,GO:0021756,GO:0030534,GO:0043235,GO:0043588,GO:0045202,GO:0048813,GO:0051965,GO:0072359,GO:1905606" protein binding|plasma membrane|chemical synaptic transmission|axonogenesis|grooming behavior|response to xenobiotic stimulus|integral component of membrane|striatum development|adult behavior|receptor complex|skin development|synapse|dendrite morphogenesis|positive regulation of synapse assembly|circulatory system development|regulation of presynapse assembly SLITRK6 6.564545421 8.323311061 4.80577978 0.577387982 -0.792387015 0.636893371 1 0.104542201 0.059351344 84189 SLIT and NTRK like family member 6 "GO:0001964,GO:0002088,GO:0002093,GO:0005886,GO:0005887,GO:0007409,GO:0007416,GO:0007601,GO:0007605,GO:0008344,GO:0009986,GO:0021562,GO:0031223,GO:0035264,GO:0051965,GO:0060007,GO:0060384,GO:0090102,GO:1905606" startle response|lens development in camera-type eye|auditory receptor cell morphogenesis|plasma membrane|integral component of plasma membrane|axonogenesis|synapse assembly|visual perception|sensory perception of sound|adult locomotory behavior|cell surface|vestibulocochlear nerve development|auditory behavior|multicellular organism growth|positive regulation of synapse assembly|linear vestibuloocular reflex|innervation|cochlea development|regulation of presynapse assembly SLK 4167.317479 4409.274035 3925.360924 0.890251069 -0.167715831 0.481993027 1 29.91163739 26.18326914 9748 STE20 like kinase "GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0006915,GO:0030334,GO:0031122,GO:0031252,GO:0042802,GO:0042803,GO:0042981,GO:0045296,GO:0046777,GO:0048471,GO:0051893,GO:0070062,GO:0106310,GO:0106311" protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|apoptotic process|regulation of cell migration|cytoplasmic microtubule organization|cell leading edge|identical protein binding|protein homodimerization activity|regulation of apoptotic process|cadherin binding|protein autophosphorylation|perinuclear region of cytoplasm|regulation of focal adhesion assembly|extracellular exosome|protein serine kinase activity|protein threonine kinase activity hsa04114 Oocyte meiosis SLMAP 1844.055347 1894.59368 1793.517014 0.946649951 -0.079097046 0.740147433 1 15.12505349 14.07853661 7871 sarcolemma associated protein "GO:0005515,GO:0005790,GO:0005815,GO:0005887,GO:0006936,GO:0042383,GO:0072659,GO:1900825,GO:1902305,GO:1905150" protein binding|smooth endoplasmic reticulum|microtubule organizing center|integral component of plasma membrane|muscle contraction|sarcolemma|protein localization to plasma membrane|regulation of membrane depolarization during cardiac muscle cell action potential|regulation of sodium ion transmembrane transport|regulation of voltage-gated sodium channel activity SLPI 16.36921938 26.01034707 6.728091692 0.258669816 -1.950816378 0.040487506 1 2.329067815 0.592378199 6590 secretory leukocyte peptidase inhibitor "GO:0003677,GO:0003729,GO:0004866,GO:0004867,GO:0005515,GO:0005576,GO:0005615,GO:0005794,GO:0006955,GO:0010951,GO:0019731,GO:0019899,GO:0032091,GO:0032496,GO:0035580,GO:0035821,GO:0043312,GO:0045071,GO:0045087,GO:0062023,GO:0070062" DNA binding|mRNA binding|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|protein binding|extracellular region|extracellular space|Golgi apparatus|immune response|negative regulation of endopeptidase activity|antibacterial humoral response|enzyme binding|negative regulation of protein binding|response to lipopolysaccharide|specific granule lumen|modulation of process of other organism|neutrophil degranulation|negative regulation of viral genome replication|innate immune response|collagen-containing extracellular matrix|extracellular exosome SLTM 1295.758575 1391.033361 1200.483789 0.863015814 -0.212541098 0.377768848 1 10.7356318 9.109982455 79811 SAFB like transcription modulator "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006915,GO:0016604,GO:0043565,GO:0050684" RNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|apoptotic process|nuclear body|sequence-specific DNA binding|regulation of mRNA processing SLU7 1370.714263 1327.568114 1413.860411 1.065000278 0.090853808 0.706884023 1 17.55012888 18.37812538 10569 "SLU7 homolog, splicing factor" "GO:0000375,GO:0000380,GO:0000386,GO:0000389,GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0005829,GO:0006405,GO:0006406,GO:0006886,GO:0008270,GO:0008380,GO:0016020,GO:0016607,GO:0030532,GO:0030628,GO:0031124,GO:0034605,GO:0043231,GO:0071013" "RNA splicing, via transesterification reactions|alternative mRNA splicing, via spliceosome|second spliceosomal transesterification activity|mRNA 3'-splice site recognition|mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|intracellular protein transport|zinc ion binding|RNA splicing|membrane|nuclear speck|small nuclear ribonucleoprotein complex|pre-mRNA 3'-splice site binding|mRNA 3'-end processing|cellular response to heat|intracellular membrane-bounded organelle|catalytic step 2 spliceosome" hsa03040 Spliceosome SLX1A 31.30676566 27.05076095 35.56277037 1.314668021 0.394698538 0.605291203 1 1.23918403 1.601854573 548593 "SLX1 homolog A, structure-specific endonuclease subunit" "GO:0000724,GO:0005515,GO:0005654,GO:0006281,GO:0008821,GO:0010792,GO:0010833,GO:0017108,GO:0033557,GO:0036297,GO:0046872,GO:0061820,GO:0090305,GO:0090656,GO:1904357,GO:1904431" double-strand break repair via homologous recombination|protein binding|nucleoplasm|DNA repair|crossover junction endodeoxyribonuclease activity|DNA double-strand break processing involved in repair via single-strand annealing|telomere maintenance via telomere lengthening|5'-flap endonuclease activity|Slx1-Slx4 complex|interstrand cross-link repair|metal ion binding|telomeric D-loop disassembly|nucleic acid phosphodiester bond hydrolysis|t-circle formation|negative regulation of telomere maintenance via telomere lengthening|positive regulation of t-circle formation hsa03460 Fanconi anemia pathway SLX1B 13.97135991 13.52538047 14.41733934 1.065947044 0.092135768 1 1 0.619592015 0.649400503 79008 "SLX1 homolog B, structure-specific endonuclease subunit" "GO:0000724,GO:0005515,GO:0005654,GO:0006281,GO:0008821,GO:0010792,GO:0010833,GO:0017108,GO:0033557,GO:0036297,GO:0046872,GO:0061820,GO:0090305,GO:0090656,GO:1904357,GO:1904431" double-strand break repair via homologous recombination|protein binding|nucleoplasm|DNA repair|crossover junction endodeoxyribonuclease activity|DNA double-strand break processing involved in repair via single-strand annealing|telomere maintenance via telomere lengthening|5'-flap endonuclease activity|Slx1-Slx4 complex|interstrand cross-link repair|metal ion binding|telomeric D-loop disassembly|nucleic acid phosphodiester bond hydrolysis|t-circle formation|negative regulation of telomere maintenance via telomere lengthening|positive regulation of t-circle formation hsa03460 Fanconi anemia pathway SLX4 370.2356999 421.3676225 319.1037774 0.757304929 -0.401053776 0.174682258 1 2.176923095 1.621007592 84464 SLX4 structure-specific endonuclease subunit "GO:0000706,GO:0000712,GO:0000724,GO:0000781,GO:0000785,GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0006260,GO:0006281,GO:0006289,GO:0008047,GO:0008821,GO:0010792,GO:0017108,GO:0019899,GO:0030054,GO:0033557,GO:0036297,GO:0046872,GO:0048257,GO:0048476,GO:0050790,GO:0061820,GO:0070522,GO:0072429,GO:0090656,GO:1904357,GO:1904431" "meiotic DNA double-strand break processing|resolution of meiotic recombination intermediates|double-strand break repair via homologous recombination|chromosome, telomeric region|chromatin|DNA binding|protein binding|nucleoplasm|cytosol|DNA replication|DNA repair|nucleotide-excision repair|enzyme activator activity|crossover junction endodeoxyribonuclease activity|DNA double-strand break processing involved in repair via single-strand annealing|5'-flap endonuclease activity|enzyme binding|cell junction|Slx1-Slx4 complex|interstrand cross-link repair|metal ion binding|3'-flap endonuclease activity|Holliday junction resolvase complex|regulation of catalytic activity|telomeric D-loop disassembly|ERCC4-ERCC1 complex|response to intra-S DNA damage checkpoint signaling|t-circle formation|negative regulation of telomere maintenance via telomere lengthening|positive regulation of t-circle formation" hsa03460 Fanconi anemia pathway SLX4IP 322.1388875 319.407062 324.8707131 1.017105605 0.024469481 0.9476009 1 1.299349634 1.299461015 128710 SLX4 interacting protein GO:0005515 protein binding SMAD1 420.2057488 446.3375557 394.073942 0.882905633 -0.179668848 0.532597376 1 8.213867245 7.130716092 4086 SMAD family member 1 "GO:0000165,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001657,GO:0001710,GO:0002051,GO:0003700,GO:0005515,GO:0005634,GO:0005637,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006468,GO:0006954,GO:0007165,GO:0007179,GO:0007183,GO:0007276,GO:0008285,GO:0009653,GO:0009880,GO:0010628,GO:0016021,GO:0016579,GO:0017151,GO:0019901,GO:0030154,GO:0030509,GO:0030901,GO:0030902,GO:0031053,GO:0032991,GO:0042592,GO:0042802,GO:0045669,GO:0045944,GO:0046872,GO:0051216,GO:0060038,GO:0060348,GO:0060395,GO:0061036,GO:0070410,GO:0070411,GO:0070878,GO:0071141,GO:0071144,GO:0071407,GO:1901522,GO:1902895,GO:1903672" "MAPK cascade|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|ureteric bud development|mesodermal cell fate commitment|osteoblast fate commitment|DNA-binding transcription factor activity|protein binding|nucleus|nuclear inner membrane|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|protein phosphorylation|inflammatory response|signal transduction|transforming growth factor beta receptor signaling pathway|SMAD protein complex assembly|gamete generation|negative regulation of cell population proliferation|anatomical structure morphogenesis|embryonic pattern specification|positive regulation of gene expression|integral component of membrane|protein deubiquitination|DEAD/H-box RNA helicase binding|protein kinase binding|cell differentiation|BMP signaling pathway|midbrain development|hindbrain development|primary miRNA processing|protein-containing complex|homeostatic process|identical protein binding|positive regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|cartilage development|cardiac muscle cell proliferation|bone development|SMAD protein signal transduction|positive regulation of cartilage development|co-SMAD binding|I-SMAD binding|primary miRNA binding|SMAD protein complex|heteromeric SMAD protein complex|cellular response to organic cyclic compound|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of sprouting angiogenesis" "hsa04350,hsa04390,hsa04550,hsa05202" TGF-beta signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Transcriptional misregulation in cancer MH1 SMAD2 1664.305935 1629.28814 1699.32373 1.042985392 0.060718952 0.800423797 1 2.087786053 2.141092334 4087 SMAD family member 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0000987,GO:0001228,GO:0001657,GO:0001701,GO:0001706,GO:0001707,GO:0003677,GO:0003682,GO:0003690,GO:0003700,GO:0005160,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006357,GO:0007179,GO:0007182,GO:0007183,GO:0007352,GO:0007369,GO:0008134,GO:0008285,GO:0009653,GO:0009749,GO:0009791,GO:0009952,GO:0010718,GO:0016579,GO:0017015,GO:0019902,GO:0023019,GO:0030073,GO:0030154,GO:0030324,GO:0030325,GO:0030509,GO:0030512,GO:0030513,GO:0031016,GO:0031053,GO:0031625,GO:0032444,GO:0032924,GO:0032991,GO:0033613,GO:0034713,GO:0035019,GO:0035265,GO:0035556,GO:0038092,GO:0042060,GO:0045165,GO:0045892,GO:0045893,GO:0045944,GO:0046332,GO:0046872,GO:0048156,GO:0048340,GO:0048617,GO:0048701,GO:0051098,GO:0060039,GO:0060395,GO:0062009,GO:0070410,GO:0070411,GO:0070412,GO:0070723,GO:0071141,GO:0071144,GO:0097718,GO:1900224" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|ureteric bud development|in utero embryonic development|endoderm formation|mesoderm formation|DNA binding|chromatin binding|double-stranded DNA binding|DNA-binding transcription factor activity|transforming growth factor beta receptor binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|transforming growth factor beta receptor signaling pathway|common-partner SMAD protein phosphorylation|SMAD protein complex assembly|zygotic specification of dorsal/ventral axis|gastrulation|transcription factor binding|negative regulation of cell population proliferation|anatomical structure morphogenesis|response to glucose|post-embryonic development|anterior/posterior pattern specification|positive regulation of epithelial to mesenchymal transition|protein deubiquitination|regulation of transforming growth factor beta receptor signaling pathway|phosphatase binding|signal transduction involved in regulation of gene expression|insulin secretion|cell differentiation|lung development|adrenal gland development|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of BMP signaling pathway|pancreas development|primary miRNA processing|ubiquitin protein ligase binding|activin responsive factor complex|activin receptor signaling pathway|protein-containing complex|activating transcription factor binding|type I transforming growth factor beta receptor binding|somatic stem cell population maintenance|organ growth|intracellular signal transduction|nodal signaling pathway|wound healing|cell fate commitment|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|SMAD binding|metal ion binding|tau protein binding|paraxial mesoderm morphogenesis|embryonic foregut morphogenesis|embryonic cranial skeleton morphogenesis|regulation of binding|pericardium development|SMAD protein signal transduction|secondary palate development|co-SMAD binding|I-SMAD binding|R-SMAD binding|response to cholesterol|SMAD protein complex|heteromeric SMAD protein complex|disordered domain specific binding|positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" "hsa04110,hsa04144,hsa04218,hsa04350,hsa04371,hsa04390,hsa04550,hsa04659,hsa04926,hsa04933,hsa05142,hsa05166,hsa05200,hsa05205,hsa05210,hsa05212,hsa05225,hsa05226,hsa05321" Cell cycle|Endocytosis|Cellular senescence|TGF-beta signaling pathway|Apelin signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Th17 cell differentiation|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Chagas disease|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Pancreatic cancer|Hepatocellular carcinoma|Gastric cancer|Inflammatory bowel disease MH1 SMAD3 6583.595432 7460.807952 5706.382911 0.764847849 -0.386755314 0.112418947 1 54.82164506 41.22857187 4088 SMAD family member 3 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0000987,GO:0001102,GO:0001223,GO:0001228,GO:0001657,GO:0001666,GO:0001701,GO:0001707,GO:0001756,GO:0001889,GO:0001947,GO:0002076,GO:0002520,GO:0003700,GO:0005160,GO:0005515,GO:0005518,GO:0005634,GO:0005637,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0005886,GO:0006357,GO:0006919,GO:0006955,GO:0007050,GO:0007179,GO:0007183,GO:0007492,GO:0008013,GO:0008134,GO:0008270,GO:0009653,GO:0009880,GO:0010628,GO:0010694,GO:0010718,GO:0016032,GO:0016202,GO:0016579,GO:0017015,GO:0017151,GO:0019901,GO:0019902,GO:0023019,GO:0030154,GO:0030308,GO:0030325,GO:0030335,GO:0030501,GO:0030509,GO:0030512,GO:0030878,GO:0031053,GO:0031490,GO:0031625,GO:0031962,GO:0032332,GO:0032731,GO:0032909,GO:0032916,GO:0032924,GO:0033689,GO:0035259,GO:0038092,GO:0042060,GO:0042110,GO:0042177,GO:0042307,GO:0042802,GO:0042803,GO:0043066,GO:0043130,GO:0043235,GO:0043425,GO:0043565,GO:0045216,GO:0045429,GO:0045599,GO:0045668,GO:0045893,GO:0045930,GO:0045944,GO:0048340,GO:0048589,GO:0048617,GO:0048701,GO:0050678,GO:0050728,GO:0050776,GO:0050821,GO:0050927,GO:0051091,GO:0051098,GO:0051481,GO:0051496,GO:0051894,GO:0060039,GO:0060290,GO:0060395,GO:0061045,GO:0061767,GO:0070306,GO:0070410,GO:0070411,GO:0070412,GO:0071141,GO:0071144,GO:0071345,GO:0071560,GO:0090263,GO:0097191,GO:0097296,GO:1901203,GO:1902895,GO:1903243" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|transcription coactivator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|ureteric bud development|response to hypoxia|in utero embryonic development|mesoderm formation|somitogenesis|liver development|heart looping|osteoblast development|immune system development|DNA-binding transcription factor activity|transforming growth factor beta receptor binding|protein binding|collagen binding|nucleus|nuclear inner membrane|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|activation of cysteine-type endopeptidase activity involved in apoptotic process|immune response|cell cycle arrest|transforming growth factor beta receptor signaling pathway|SMAD protein complex assembly|endoderm development|beta-catenin binding|transcription factor binding|zinc ion binding|anatomical structure morphogenesis|embryonic pattern specification|positive regulation of gene expression|positive regulation of alkaline phosphatase activity|positive regulation of epithelial to mesenchymal transition|viral process|regulation of striated muscle tissue development|protein deubiquitination|regulation of transforming growth factor beta receptor signaling pathway|DEAD/H-box RNA helicase binding|protein kinase binding|phosphatase binding|signal transduction involved in regulation of gene expression|cell differentiation|negative regulation of cell growth|adrenal gland development|positive regulation of cell migration|positive regulation of bone mineralization|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|thyroid gland development|primary miRNA processing|chromatin DNA binding|ubiquitin protein ligase binding|mineralocorticoid receptor binding|positive regulation of chondrocyte differentiation|positive regulation of interleukin-1 beta production|regulation of transforming growth factor beta2 production|positive regulation of transforming growth factor beta3 production|activin receptor signaling pathway|negative regulation of osteoblast proliferation|glucocorticoid receptor binding|nodal signaling pathway|wound healing|T cell activation|negative regulation of protein catabolic process|positive regulation of protein import into nucleus|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|ubiquitin binding|receptor complex|bHLH transcription factor binding|sequence-specific DNA binding|cell-cell junction organization|positive regulation of nitric oxide biosynthetic process|negative regulation of fat cell differentiation|negative regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|paraxial mesoderm morphogenesis|developmental growth|embryonic foregut morphogenesis|embryonic cranial skeleton morphogenesis|regulation of epithelial cell proliferation|negative regulation of inflammatory response|regulation of immune response|protein stabilization|positive regulation of positive chemotaxis|positive regulation of DNA-binding transcription factor activity|regulation of binding|negative regulation of cytosolic calcium ion concentration|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|pericardium development|transdifferentiation|SMAD protein signal transduction|negative regulation of wound healing|negative regulation of lung blood pressure|lens fiber cell differentiation|co-SMAD binding|I-SMAD binding|R-SMAD binding|SMAD protein complex|heteromeric SMAD protein complex|cellular response to cytokine stimulus|cellular response to transforming growth factor beta stimulus|positive regulation of canonical Wnt signaling pathway|extrinsic apoptotic signaling pathway|activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|positive regulation of extracellular matrix assembly|positive regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of cardiac muscle hypertrophy in response to stress" "hsa04068,hsa04110,hsa04144,hsa04218,hsa04310,hsa04350,hsa04371,hsa04390,hsa04520,hsa04550,hsa04659,hsa04933,hsa05161,hsa05166,hsa05200,hsa05210,hsa05212,hsa05220,hsa05225,hsa05226,hsa05321" FoxO signaling pathway|Cell cycle|Endocytosis|Cellular senescence|Wnt signaling pathway|TGF-beta signaling pathway|Apelin signaling pathway|Hippo signaling pathway|Adherens junction|Signaling pathways regulating pluripotency of stem cells|Th17 cell differentiation|AGE-RAGE signaling pathway in diabetic complications|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer|Inflammatory bowel disease MH1 SMAD4 1770.031862 1831.128433 1708.93529 0.933268939 -0.099635215 0.675862561 1 11.1404422 10.22304848 4089 SMAD family member 4 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001085,GO:0001223,GO:0001228,GO:0001541,GO:0001658,GO:0001666,GO:0001701,GO:0001702,GO:0003148,GO:0003190,GO:0003198,GO:0003220,GO:0003251,GO:0003360,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005518,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005813,GO:0005829,GO:0006357,GO:0006879,GO:0007179,GO:0007183,GO:0007283,GO:0007338,GO:0007411,GO:0008283,GO:0008285,GO:0009653,GO:0010614,GO:0010718,GO:0010862,GO:0014033,GO:0016579,GO:0017015,GO:0030154,GO:0030308,GO:0030509,GO:0030511,GO:0030513,GO:0032444,GO:0032525,GO:0032909,GO:0033686,GO:0035019,GO:0035556,GO:0036302,GO:0042118,GO:0042733,GO:0042802,GO:0042803,GO:0043199,GO:0043565,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0046881,GO:0048382,GO:0048589,GO:0048663,GO:0048733,GO:0048859,GO:0051098,GO:0051571,GO:0051797,GO:0060065,GO:0060391,GO:0060395,GO:0060412,GO:0060548,GO:0060956,GO:0061040,GO:0062009,GO:0070102,GO:0070373,GO:0070411,GO:0070412,GO:0071141,GO:0071144,GO:0071559,GO:0071773,GO:0072133,GO:0072134,GO:0072520,GO:0140537,GO:1901522,GO:1902895,GO:1905305,GO:2000617" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|transcription coactivator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|ovarian follicle development|branching involved in ureteric bud morphogenesis|response to hypoxia|in utero embryonic development|gastrulation with mouth forming second|outflow tract septum morphogenesis|atrioventricular valve formation|epithelial to mesenchymal transition involved in endocardial cushion formation|left ventricular cardiac muscle tissue morphogenesis|positive regulation of cell proliferation involved in heart valve morphogenesis|brainstem development|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|collagen binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|centrosome|cytosol|regulation of transcription by RNA polymerase II|cellular iron ion homeostasis|transforming growth factor beta receptor signaling pathway|SMAD protein complex assembly|spermatogenesis|single fertilization|axon guidance|cell population proliferation|negative regulation of cell population proliferation|anatomical structure morphogenesis|negative regulation of cardiac muscle hypertrophy|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|neural crest cell differentiation|protein deubiquitination|regulation of transforming growth factor beta receptor signaling pathway|cell differentiation|negative regulation of cell growth|BMP signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of BMP signaling pathway|activin responsive factor complex|somite rostral/caudal axis specification|regulation of transforming growth factor beta2 production|positive regulation of luteinizing hormone secretion|somatic stem cell population maintenance|intracellular signal transduction|atrioventricular canal development|endothelial cell activation|embryonic digit morphogenesis|identical protein binding|protein homodimerization activity|sulfate binding|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of follicle-stimulating hormone secretion|mesendoderm development|developmental growth|neuron fate commitment|sebaceous gland development|formation of anatomical boundary|regulation of binding|positive regulation of histone H3-K4 methylation|regulation of hair follicle development|uterus development|positive regulation of SMAD protein signal transduction|SMAD protein signal transduction|ventricular septum morphogenesis|negative regulation of cell death|endocardial cell differentiation|female gonad morphogenesis|secondary palate development|interleukin-6-mediated signaling pathway|negative regulation of ERK1 and ERK2 cascade|I-SMAD binding|R-SMAD binding|SMAD protein complex|heteromeric SMAD protein complex|response to transforming growth factor beta|cellular response to BMP stimulus|metanephric mesenchyme morphogenesis|nephrogenic mesenchyme morphogenesis|seminiferous tubule development|transcription regulator activator activity|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|positive regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of cardiac myofibril assembly|positive regulation of histone H3-K9 acetylation" "hsa04068,hsa04110,hsa04310,hsa04350,hsa04371,hsa04390,hsa04520,hsa04550,hsa04659,hsa04933,hsa05161,hsa05166,hsa05200,hsa05210,hsa05212,hsa05220,hsa05225,hsa05226" FoxO signaling pathway|Cell cycle|Wnt signaling pathway|TGF-beta signaling pathway|Apelin signaling pathway|Hippo signaling pathway|Adherens junction|Signaling pathways regulating pluripotency of stem cells|Th17 cell differentiation|AGE-RAGE signaling pathway in diabetic complications|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer MH1 SMAD5 2082.475516 2060.019488 2104.931544 1.021801763 0.03111533 0.897333605 1 14.47714694 14.54523722 4090 SMAD family member 5 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001657,GO:0001880,GO:0002051,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006468,GO:0007165,GO:0007179,GO:0007281,GO:0009653,GO:0009880,GO:0017151,GO:0030154,GO:0030218,GO:0030509,GO:0031625,GO:0032991,GO:0045669,GO:0045893,GO:0046872,GO:0051216,GO:0060048,GO:0060348,GO:0060395,GO:0070411,GO:0071141,GO:0071144,GO:0071407,GO:1901522,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|ureteric bud development|Mullerian duct regression|osteoblast fate commitment|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|protein phosphorylation|signal transduction|transforming growth factor beta receptor signaling pathway|germ cell development|anatomical structure morphogenesis|embryonic pattern specification|DEAD/H-box RNA helicase binding|cell differentiation|erythrocyte differentiation|BMP signaling pathway|ubiquitin protein ligase binding|protein-containing complex|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|metal ion binding|cartilage development|cardiac muscle contraction|bone development|SMAD protein signal transduction|I-SMAD binding|SMAD protein complex|heteromeric SMAD protein complex|cellular response to organic cyclic compound|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|sequence-specific double-stranded DNA binding" "hsa04350,hsa04550" TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells SMAD6 7.124381325 10.40413883 3.844623824 0.369528309 -1.436243205 0.311438224 1 0.072838747 0.026465576 4091 SMAD family member 6 "GO:0000785,GO:0000976,GO:0001657,GO:0003148,GO:0003180,GO:0003183,GO:0003184,GO:0003281,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006357,GO:0006955,GO:0007179,GO:0007352,GO:0008285,GO:0009653,GO:0010991,GO:0016604,GO:0030154,GO:0030279,GO:0030509,GO:0030512,GO:0030514,GO:0031589,GO:0031625,GO:0032496,GO:0032991,GO:0034616,GO:0034713,GO:0035904,GO:0042802,GO:0043066,GO:0043627,GO:0045444,GO:0045668,GO:0046872,GO:0060394,GO:0060395,GO:0060976,GO:0070410,GO:0070411,GO:0070412,GO:0070698,GO:0071144,GO:0140416,GO:1902895" chromatin|transcription regulatory region sequence-specific DNA binding|ureteric bud development|outflow tract septum morphogenesis|aortic valve morphogenesis|mitral valve morphogenesis|pulmonary valve morphogenesis|ventricular septum development|chromatin binding|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|regulation of transcription by RNA polymerase II|immune response|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis|negative regulation of cell population proliferation|anatomical structure morphogenesis|negative regulation of SMAD protein complex assembly|nuclear body|cell differentiation|negative regulation of ossification|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|cell-substrate adhesion|ubiquitin protein ligase binding|response to lipopolysaccharide|protein-containing complex|response to laminar fluid shear stress|type I transforming growth factor beta receptor binding|aorta development|identical protein binding|negative regulation of apoptotic process|response to estrogen|fat cell differentiation|negative regulation of osteoblast differentiation|metal ion binding|negative regulation of pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction|coronary vasculature development|co-SMAD binding|I-SMAD binding|R-SMAD binding|type I activin receptor binding|heteromeric SMAD protein complex|transcription regulator inhibitor activity|positive regulation of pri-miRNA transcription by RNA polymerase II hsa04350 TGF-beta signaling pathway SMAD7 104.8396123 115.485941 94.19328369 0.815625546 -0.294021132 0.531748526 1 1.666650194 1.336615384 4092 SMAD family member 7 "GO:0000122,GO:0000785,GO:0001650,GO:0001657,GO:0002725,GO:0003677,GO:0005515,GO:0005518,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0005912,GO:0006357,GO:0007179,GO:0008013,GO:0009653,GO:0010717,GO:0010719,GO:0010801,GO:0010944,GO:0016342,GO:0016579,GO:0017015,GO:0022409,GO:0030154,GO:0030279,GO:0030336,GO:0030509,GO:0030512,GO:0030514,GO:0031397,GO:0031398,GO:0031625,GO:0032436,GO:0032925,GO:0032991,GO:0033137,GO:0034333,GO:0034616,GO:0034629,GO:0034713,GO:0043433,GO:0045944,GO:0046872,GO:0048185,GO:0048844,GO:0050821,GO:0051444,GO:0055010,GO:0055117,GO:0060373,GO:0060389,GO:0060394,GO:0060395,GO:0060412,GO:0070411,GO:0071144,GO:0071560,GO:0140416,GO:1902731,GO:1903043,GO:1990830,GO:2000317,GO:2000320" negative regulation of transcription by RNA polymerase II|chromatin|fibrillar center|ureteric bud development|negative regulation of T cell cytokine production|DNA binding|protein binding|collagen binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|plasma membrane|adherens junction|regulation of transcription by RNA polymerase II|transforming growth factor beta receptor signaling pathway|beta-catenin binding|anatomical structure morphogenesis|regulation of epithelial to mesenchymal transition|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-threonine phosphorylation|negative regulation of transcription by competitive promoter binding|catenin complex|protein deubiquitination|regulation of transforming growth factor beta receptor signaling pathway|positive regulation of cell-cell adhesion|cell differentiation|negative regulation of ossification|negative regulation of cell migration|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of protein ubiquitination|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of activin receptor signaling pathway|protein-containing complex|negative regulation of peptidyl-serine phosphorylation|adherens junction assembly|response to laminar fluid shear stress|cellular protein-containing complex localization|type I transforming growth factor beta receptor binding|negative regulation of DNA-binding transcription factor activity|positive regulation of transcription by RNA polymerase II|metal ion binding|activin binding|artery morphogenesis|protein stabilization|negative regulation of ubiquitin-protein transferase activity|ventricular cardiac muscle tissue morphogenesis|regulation of cardiac muscle contraction|regulation of ventricular cardiac muscle cell membrane depolarization|pathway-restricted SMAD protein phosphorylation|negative regulation of pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction|ventricular septum morphogenesis|I-SMAD binding|heteromeric SMAD protein complex|cellular response to transforming growth factor beta stimulus|transcription regulator inhibitor activity|negative regulation of chondrocyte proliferation|positive regulation of chondrocyte hypertrophy|cellular response to leukemia inhibitory factor|negative regulation of T-helper 17 type immune response|negative regulation of T-helper 17 cell differentiation "hsa04350,hsa04390" TGF-beta signaling pathway|Hippo signaling pathway SMAD9 180.3991809 143.5771158 217.2212461 1.512923873 0.597339396 0.114432324 1 0.87371115 1.299738946 4093 SMAD family member 9 "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0007179,GO:0009653,GO:0030154,GO:0030509,GO:0046872,GO:0060395,GO:0070411,GO:0071141,GO:0071144,GO:0071773,GO:1901522" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|transforming growth factor beta receptor signaling pathway|anatomical structure morphogenesis|cell differentiation|BMP signaling pathway|metal ion binding|SMAD protein signal transduction|I-SMAD binding|SMAD protein complex|heteromeric SMAD protein complex|cellular response to BMP stimulus|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" "hsa04350,hsa04550" TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells SMAGP 928.005023 971.7465664 884.2634795 0.909973351 -0.136103799 0.584601748 1 25.58476974 22.89187497 57228 small cell adhesion glycoprotein "GO:0005515,GO:0005654,GO:0005886,GO:0016021,GO:0030054,GO:0030659" protein binding|nucleoplasm|plasma membrane|integral component of membrane|cell junction|cytoplasmic vesicle membrane SMAP1 857.1329616 839.6140033 874.65192 1.041730982 0.058982762 0.817345795 1 9.517556544 9.748823885 60682 small ArfGAP 1 "GO:0005096,GO:0005737,GO:0005886,GO:0030276,GO:0043547,GO:0045648,GO:0046872,GO:2000369" GTPase activator activity|cytoplasm|plasma membrane|clathrin binding|positive regulation of GTPase activity|positive regulation of erythrocyte differentiation|metal ion binding|regulation of clathrin-dependent endocytosis hsa04144 Endocytosis SMAP2 847.8484946 822.9673812 872.729608 1.060466828 0.084699493 0.738267844 1 12.82717774 13.37517211 64744 small ArfGAP2 "GO:0005096,GO:0005515,GO:0005737,GO:0043547,GO:0046872" GTPase activator activity|protein binding|cytoplasm|positive regulation of GTPase activity|metal ion binding hsa04144 Endocytosis SMARCA1 4715.271952 4172.059669 5258.484235 1.260404848 0.333887209 0.1633959 1 54.39901213 67.41743992 6594 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1" "GO:0000733,GO:0003677,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006338,GO:0007420,GO:0008094,GO:0008134,GO:0016589,GO:0030182,GO:0031491,GO:0036310,GO:0043044,GO:0043231,GO:0045893,GO:0045944,GO:0070615,GO:0090537" "DNA strand renaturation|DNA binding|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|chromatin remodeling|brain development|DNA-dependent ATPase activity|transcription factor binding|NURF complex|neuron differentiation|nucleosome binding|annealing helicase activity|ATP-dependent chromatin remodeling|intracellular membrane-bounded organelle|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|nucleosome-dependent ATPase activity|CERF complex" SMARCA2 1264.501499 1340.053081 1188.949918 0.887240912 -0.172602203 0.475105909 1 10.55277704 9.206180819 6595 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2" "GO:0000122,GO:0000785,GO:0000976,GO:0003677,GO:0003682,GO:0003713,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006338,GO:0006355,GO:0006357,GO:0007286,GO:0007399,GO:0008094,GO:0008285,GO:0016514,GO:0030308,GO:0042393,GO:0043044,GO:0043231,GO:0045111,GO:0045892,GO:0045893,GO:0045944,GO:0071564,GO:0071565" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|DNA binding|chromatin binding|transcription coactivator activity|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|chromatin remodeling|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|spermatid development|nervous system development|DNA-dependent ATPase activity|negative regulation of cell population proliferation|SWI/SNF complex|negative regulation of cell growth|histone binding|ATP-dependent chromatin remodeling|intracellular membrane-bounded organelle|intermediate filament cytoskeleton|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|npBAF complex|nBAF complex" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma SMARCA4 2231.364141 2284.748886 2177.979396 0.953268611 -0.069045303 0.77164596 1 20.11761242 18.85657914 6597 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4" "GO:0000122,GO:0000785,GO:0001164,GO:0001188,GO:0002039,GO:0003407,GO:0003677,GO:0003713,GO:0003714,GO:0003723,GO:0004386,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005654,GO:0005730,GO:0006325,GO:0006337,GO:0006338,GO:0006357,GO:0007399,GO:0008094,GO:0008134,GO:0016020,GO:0016514,GO:0030177,GO:0030308,GO:0030957,GO:0031492,GO:0032991,GO:0038111,GO:0043044,GO:0043923,GO:0045892,GO:0045893,GO:0045944,GO:0047485,GO:0050681,GO:0051091,GO:0060766,GO:0070182,GO:0070577,GO:0071564,GO:0071565,GO:1901838,GO:1902661,GO:1902895,GO:1904837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase I core promoter sequence-specific DNA binding|RNA polymerase I preinitiation complex assembly|p53 binding|neural retina development|DNA binding|transcription coactivator activity|transcription corepressor activity|RNA binding|helicase activity|protein binding|ATP binding|extracellular space|nucleus|nucleoplasm|nucleolus|chromatin organization|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|nervous system development|DNA-dependent ATPase activity|transcription factor binding|membrane|SWI/SNF complex|positive regulation of Wnt signaling pathway|negative regulation of cell growth|Tat protein binding|nucleosomal DNA binding|protein-containing complex|interleukin-7-mediated signaling pathway|ATP-dependent chromatin remodeling|positive regulation by host of viral transcription|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein N-terminus binding|androgen receptor binding|positive regulation of DNA-binding transcription factor activity|negative regulation of androgen receptor signaling pathway|DNA polymerase binding|lysine-acetylated histone binding|npBAF complex|nBAF complex|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|positive regulation of glucose mediated signaling pathway|positive regulation of pri-miRNA transcription by RNA polymerase II|beta-catenin-TCF complex assembly" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma chromosome_remodelling_factor SMARCA5 3142.35079 3251.293383 3033.408197 0.932985074 -0.100074094 0.67340407 1 22.58140971 20.71557178 8467 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5" "GO:0000183,GO:0000793,GO:0001650,GO:0003677,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005677,GO:0005829,GO:0006334,GO:0006338,GO:0006352,GO:0006357,GO:0008094,GO:0016584,GO:0016589,GO:0016887,GO:0031213,GO:0031491,GO:0034080,GO:0042393,GO:0043044,GO:0043231,GO:0043596,GO:0045815,GO:0045944,GO:1990830" "rDNA heterochromatin assembly|condensed chromosome|fibrillar center|DNA binding|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|chromatin silencing complex|cytosol|nucleosome assembly|chromatin remodeling|DNA-templated transcription, initiation|regulation of transcription by RNA polymerase II|DNA-dependent ATPase activity|nucleosome positioning|NURF complex|ATPase activity|RSF complex|nucleosome binding|CENP-A containing nucleosome assembly|histone binding|ATP-dependent chromatin remodeling|intracellular membrane-bounded organelle|nuclear replication fork|positive regulation of gene expression, epigenetic|positive regulation of transcription by RNA polymerase II|cellular response to leukemia inhibitory factor" SMARCAD1 1030.327889 1071.626299 989.0294787 0.922923858 -0.115716465 0.639206095 1 10.41725428 9.453449683 56916 "SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1" "GO:0000018,GO:0000729,GO:0000792,GO:0003677,GO:0003678,GO:0003682,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006338,GO:0008094,GO:0032508,GO:0035861,GO:0043044,GO:0043130,GO:0043596,GO:0051304,GO:0070932,GO:0070933" regulation of DNA recombination|DNA double-strand break processing|heterochromatin|DNA binding|DNA helicase activity|chromatin binding|protein binding|ATP binding|nucleus|nucleoplasm|chromatin remodeling|DNA-dependent ATPase activity|DNA duplex unwinding|site of double-strand break|ATP-dependent chromatin remodeling|ubiquitin binding|nuclear replication fork|chromosome separation|histone H3 deacetylation|histone H4 deacetylation hsa04550 Signaling pathways regulating pluripotency of stem cells SMARCAL1 1173.896173 1181.910171 1165.882175 0.986438905 -0.019698394 0.938995631 1 19.4981062 18.91184076 50485 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1" "GO:0000733,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005662,GO:0006259,GO:0006281,GO:0006303,GO:0006357,GO:0006974,GO:0008094,GO:0031297,GO:0032508,GO:0035861,GO:0036310,GO:0043596,GO:0048478,GO:0090656" DNA strand renaturation|protein binding|ATP binding|nucleus|nucleoplasm|DNA replication factor A complex|DNA metabolic process|DNA repair|double-strand break repair via nonhomologous end joining|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|DNA-dependent ATPase activity|replication fork processing|DNA duplex unwinding|site of double-strand break|annealing helicase activity|nuclear replication fork|replication fork protection|t-circle formation SMARCB1 1185.821918 1103.879129 1267.764706 1.148463335 0.199704798 0.410734344 1 11.40821075 12.88266901 6598 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1" "GO:0000228,GO:0000785,GO:0001164,GO:0001188,GO:0001650,GO:0002039,GO:0003677,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006337,GO:0006338,GO:0006357,GO:0007049,GO:0007399,GO:0015074,GO:0016514,GO:0030957,GO:0031492,GO:0032991,GO:0035060,GO:0039692,GO:0043044,GO:0043231,GO:0043923,GO:0045944,GO:0051091,GO:0071564,GO:0071565,GO:0090240,GO:1900110,GO:1900113,GO:1901838,GO:1902661,GO:2000617,GO:2000618" nuclear chromosome|chromatin|RNA polymerase I core promoter sequence-specific DNA binding|RNA polymerase I preinitiation complex assembly|fibrillar center|p53 binding|DNA binding|transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|nucleoplasm|nucleolus|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|cell cycle|nervous system development|DNA integration|SWI/SNF complex|Tat protein binding|nucleosomal DNA binding|protein-containing complex|brahma complex|single stranded viral RNA replication via double stranded DNA intermediate|ATP-dependent chromatin remodeling|intracellular membrane-bounded organelle|positive regulation by host of viral transcription|positive regulation of transcription by RNA polymerase II|positive regulation of DNA-binding transcription factor activity|npBAF complex|nBAF complex|positive regulation of histone H4 acetylation|negative regulation of histone H3-K9 dimethylation|negative regulation of histone H3-K9 trimethylation|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|positive regulation of glucose mediated signaling pathway|positive regulation of histone H3-K9 acetylation|regulation of histone H4-K16 acetylation "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma chromosome_remodelling_factor SMARCC1 2646.140108 2689.469887 2602.810329 0.967778201 -0.047251652 0.842995006 1 22.58924533 21.49555863 6599 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1" "GO:0000785,GO:0001741,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006337,GO:0006338,GO:0006357,GO:0007399,GO:0008286,GO:0009887,GO:0016514,GO:0030850,GO:0031492,GO:0032435,GO:0032991,GO:0042393,GO:0043044,GO:0045893,GO:0045944,GO:0047485,GO:0071564,GO:0071565" "chromatin|XY body|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|nervous system development|insulin receptor signaling pathway|animal organ morphogenesis|SWI/SNF complex|prostate gland development|nucleosomal DNA binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein-containing complex|histone binding|ATP-dependent chromatin remodeling|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein N-terminus binding|npBAF complex|nBAF complex" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma chromosome_remodelling_factor SMARCC2 3180.727831 3224.242622 3137.21304 0.973007744 -0.039476808 0.868871807 1 33.95262487 32.48335142 6601 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2" "GO:0000785,GO:0003713,GO:0005515,GO:0005654,GO:0006337,GO:0006338,GO:0006357,GO:0007399,GO:0016514,GO:0031492,GO:0032991,GO:0042393,GO:0043044,GO:0045892,GO:0045893,GO:0071564,GO:0071565" "chromatin|transcription coactivator activity|protein binding|nucleoplasm|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|nervous system development|SWI/SNF complex|nucleosomal DNA binding|protein-containing complex|histone binding|ATP-dependent chromatin remodeling|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|npBAF complex|nBAF complex" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma chromosome_remodelling_factor SMARCD1 1771.429551 1741.65284 1801.206262 1.034193624 0.048506315 0.840087788 1 27.07509788 27.53233656 6602 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1" "GO:0001228,GO:0003682,GO:0003713,GO:0005102,GO:0005515,GO:0005634,GO:0005654,GO:0006337,GO:0006338,GO:0006357,GO:0007399,GO:0016514,GO:0043231,GO:0045944,GO:0048096,GO:0060090,GO:0071398,GO:0071564,GO:0071565" "DNA-binding transcription activator activity, RNA polymerase II-specific|chromatin binding|transcription coactivator activity|signaling receptor binding|protein binding|nucleus|nucleoplasm|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|nervous system development|SWI/SNF complex|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|chromatin-mediated maintenance of transcription|molecular adaptor activity|cellular response to fatty acid|npBAF complex|nBAF complex" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma SMARCD2 1694.734604 1847.775056 1541.694153 0.834351643 -0.26127255 0.271364893 1 37.05838356 30.40232351 6603 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2" "GO:0000785,GO:0001228,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006337,GO:0006338,GO:0006357,GO:0016514,GO:0031492,GO:0032991,GO:0043044,GO:0045944" "chromatin|DNA-binding transcription activator activity, RNA polymerase II-specific|transcription coactivator activity|protein binding|nucleus|nucleoplasm|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|SWI/SNF complex|nucleosomal DNA binding|protein-containing complex|ATP-dependent chromatin remodeling|positive regulation of transcription by RNA polymerase II" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma SMARCD3 323.2585594 323.5687175 322.9484012 0.998082892 -0.002768457 1 1 8.184013156 8.031637684 6604 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3" "GO:0000785,GO:0001228,GO:0002052,GO:0003139,GO:0003219,GO:0003407,GO:0003682,GO:0003713,GO:0005102,GO:0005634,GO:0005654,GO:0006337,GO:0006338,GO:0006357,GO:0008134,GO:0010971,GO:0016514,GO:0019216,GO:0035257,GO:0042692,GO:0043393,GO:0045893,GO:0045944,GO:0051152,GO:0071564,GO:0071565" "chromatin|DNA-binding transcription activator activity, RNA polymerase II-specific|positive regulation of neuroblast proliferation|secondary heart field specification|cardiac right ventricle formation|neural retina development|chromatin binding|transcription coactivator activity|signaling receptor binding|nucleus|nucleoplasm|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|transcription factor binding|positive regulation of G2/M transition of mitotic cell cycle|SWI/SNF complex|regulation of lipid metabolic process|nuclear hormone receptor binding|muscle cell differentiation|regulation of protein binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of smooth muscle cell differentiation|npBAF complex|nBAF complex" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma SMARCE1 2099.161767 2094.353146 2103.970388 1.004591987 0.006609672 0.979968084 1 21.70325789 21.43807664 6605 "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1" "GO:0000228,GO:0000785,GO:0003682,GO:0003713,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006337,GO:0006338,GO:0006357,GO:0008080,GO:0016514,GO:0016922,GO:0022008,GO:0031492,GO:0032991,GO:0043044,GO:0045892,GO:0045893,GO:0047485,GO:0071564,GO:0071565" "nuclear chromosome|chromatin|chromatin binding|transcription coactivator activity|RNA binding|protein binding|nucleus|nucleoplasm|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|N-acetyltransferase activity|SWI/SNF complex|nuclear receptor binding|neurogenesis|nucleosomal DNA binding|protein-containing complex|ATP-dependent chromatin remodeling|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein N-terminus binding|npBAF complex|nBAF complex" "hsa04714,hsa05225" Thermogenesis|Hepatocellular carcinoma chromosome_remodelling_factor SMC1A 4066.592406 4717.236544 3415.948268 0.724141822 -0.46565582 0.050890867 1 25.54284136 18.18712348 8243 structural maintenance of chromosomes 1A "GO:0000070,GO:0000775,GO:0000776,GO:0000777,GO:0000794,GO:0003682,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006281,GO:0007062,GO:0007064,GO:0008278,GO:0009314,GO:0016363,GO:0019827,GO:0030893,GO:0036033,GO:0046982,GO:0051301,GO:0051321,GO:0072423,GO:0090307,GO:0097431" "mitotic sister chromatid segregation|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|condensed nuclear chromosome|chromatin binding|RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|chromosome|cytosol|DNA repair|sister chromatid cohesion|mitotic sister chromatid cohesion|cohesin complex|response to radiation|nuclear matrix|stem cell population maintenance|meiotic cohesin complex|mediator complex binding|protein heterodimerization activity|cell division|meiotic cell cycle|response to DNA damage checkpoint signaling|mitotic spindle assembly|mitotic spindle pole" "hsa04110,hsa04114" Cell cycle|Oocyte meiosis other SMC1B 6.004709516 6.242483296 5.766935736 0.923820772 -0.11431511 1 1 0.076993266 0.069937748 27127 structural maintenance of chromosomes 1B "GO:0000775,GO:0000800,GO:0003677,GO:0005524,GO:0005654,GO:0005829,GO:0007064,GO:0030893,GO:0034991,GO:0051321" "chromosome, centromeric region|lateral element|DNA binding|ATP binding|nucleoplasm|cytosol|mitotic sister chromatid cohesion|meiotic cohesin complex|nuclear meiotic cohesin complex|meiotic cell cycle" "hsa04110,hsa04114" Cell cycle|Oocyte meiosis SMC2 3150.298548 3106.675854 3193.921242 1.028083196 0.039957018 0.867279907 1 18.7575043 18.96157875 10592 structural maintenance of chromosomes 2 "GO:0000228,GO:0000793,GO:0000796,GO:0003682,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0007076,GO:0010032,GO:0045132,GO:0051301,GO:0051383,GO:0070062" nuclear chromosome|condensed chromosome|condensin complex|chromatin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|mitotic chromosome condensation|meiotic chromosome condensation|meiotic chromosome segregation|cell division|kinetochore organization|extracellular exosome SMC3 2110.25972 2082.908593 2137.610846 1.026262436 0.037399704 0.87623866 1 20.13056925 20.31354251 9126 structural maintenance of chromosomes 3 "GO:0000278,GO:0000775,GO:0000785,GO:0000800,GO:0003682,GO:0003777,GO:0005515,GO:0005524,GO:0005654,GO:0005694,GO:0005829,GO:0006275,GO:0006281,GO:0007062,GO:0008278,GO:0016363,GO:0019827,GO:0030893,GO:0034991,GO:0036033,GO:0046982,GO:0048487,GO:0051301,GO:0051321,GO:0070840,GO:0090307,GO:0097431" "mitotic cell cycle|chromosome, centromeric region|chromatin|lateral element|chromatin binding|microtubule motor activity|protein binding|ATP binding|nucleoplasm|chromosome|cytosol|regulation of DNA replication|DNA repair|sister chromatid cohesion|cohesin complex|nuclear matrix|stem cell population maintenance|meiotic cohesin complex|nuclear meiotic cohesin complex|mediator complex binding|protein heterodimerization activity|beta-tubulin binding|cell division|meiotic cell cycle|dynein complex binding|mitotic spindle assembly|mitotic spindle pole" "hsa04110,hsa04114" Cell cycle|Oocyte meiosis other SMC4 5084.348467 5383.101429 4785.595505 0.889003406 -0.169739149 0.479937716 1 53.28997023 46.58220916 10051 structural maintenance of chromosomes 4 "GO:0000070,GO:0000775,GO:0000796,GO:0003682,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0007076,GO:0010032,GO:0016607,GO:0045132,GO:0051301,GO:0051383" "mitotic sister chromatid segregation|chromosome, centromeric region|condensin complex|chromatin binding|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|mitotic chromosome condensation|meiotic chromosome condensation|nuclear speck|meiotic chromosome segregation|cell division|kinetochore organization" SMC5 1712.92234 1833.209261 1592.635419 0.868769023 -0.202955432 0.393017243 1 16.77555024 14.33020093 23137 structural maintenance of chromosomes 5 "GO:0000722,GO:0000724,GO:0000775,GO:0000781,GO:0000803,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006303,GO:0006974,GO:0007062,GO:0016605,GO:0016607,GO:0018393,GO:0019827,GO:0030054,GO:0030261,GO:0030915,GO:0034184,GO:0035061,GO:0035861,GO:0044772,GO:0051301,GO:0051984,GO:0071459,GO:0090398" "telomere maintenance via recombination|double-strand break repair via homologous recombination|chromosome, centromeric region|chromosome, telomeric region|sex chromosome|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|double-strand break repair via nonhomologous end joining|cellular response to DNA damage stimulus|sister chromatid cohesion|PML body|nuclear speck|internal peptidyl-lysine acetylation|stem cell population maintenance|cell junction|chromosome condensation|Smc5-Smc6 complex|positive regulation of maintenance of mitotic sister chromatid cohesion|interchromatin granule|site of double-strand break|mitotic cell cycle phase transition|cell division|positive regulation of chromosome segregation|protein localization to chromosome, centromeric region|cellular senescence" SMC6 1075.729932 1102.838716 1048.621148 0.950838172 -0.072728273 0.768901598 1 10.60477033 9.914688044 79677 structural maintenance of chromosomes 6 "GO:0000722,GO:0000775,GO:0000781,GO:0000803,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006281,GO:0006974,GO:0016605,GO:0016607,GO:0030915,GO:0031625,GO:0035061,GO:0035861,GO:0051984,GO:0090398,GO:0097431" "telomere maintenance via recombination|chromosome, centromeric region|chromosome, telomeric region|sex chromosome|protein binding|ATP binding|nucleus|nucleoplasm|DNA repair|cellular response to DNA damage stimulus|PML body|nuclear speck|Smc5-Smc6 complex|ubiquitin protein ligase binding|interchromatin granule|site of double-strand break|positive regulation of chromosome segregation|cellular senescence|mitotic spindle pole" SMCHD1 3560.243582 3573.821687 3546.665478 0.992401353 -0.011004393 0.964315189 1 17.3342084 16.91463147 23347 structural maintenance of chromosomes flexible hinge domain containing 1 "GO:0000781,GO:0001740,GO:0003677,GO:0005515,GO:0005524,GO:0006302,GO:0009048,GO:0016887,GO:0035861,GO:0042803,GO:0043584,GO:0045739,GO:0060820,GO:0060821,GO:0070868,GO:2000042,GO:2001034" "chromosome, telomeric region|Barr body|DNA binding|protein binding|ATP binding|double-strand break repair|dosage compensation by inactivation of X chromosome|ATPase activity|site of double-strand break|protein homodimerization activity|nose development|positive regulation of DNA repair|inactivation of X chromosome by heterochromatin assembly|inactivation of X chromosome by DNA methylation|heterochromatin organization involved in chromatin silencing|negative regulation of double-strand break repair via homologous recombination|positive regulation of double-strand break repair via nonhomologous end joining" SMCO2 28.58181365 31.21241648 25.95121081 0.831438695 -0.266318203 0.755121625 1 0.259907833 0.212481332 341346 single-pass membrane protein with coiled-coil domains 2 GO:0016021 integral component of membrane SMCO4 180.1859449 175.8299462 184.5419436 1.049547859 0.069767955 0.867938389 1 1.98345404 2.04689501 56935 single-pass membrane protein with coiled-coil domains 4 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane SMCR8 1328.318376 1488.832266 1167.804487 0.784376127 -0.350382468 0.144766221 1 9.576502553 7.385883864 140775 SMCR8-C9orf72 complex subunit "GO:0000785,GO:0004860,GO:0005085,GO:0005515,GO:0005654,GO:0005737,GO:0006469,GO:0006914,GO:0010506,GO:0010629,GO:0016242,GO:0019901,GO:0032008,GO:0032045,GO:1901098,GO:1902902,GO:1903432,GO:1990316" chromatin|protein kinase inhibitor activity|guanyl-nucleotide exchange factor activity|protein binding|nucleoplasm|cytoplasm|negative regulation of protein kinase activity|autophagy|regulation of autophagy|negative regulation of gene expression|negative regulation of macroautophagy|protein kinase binding|positive regulation of TOR signaling|guanyl-nucleotide exchange factor complex|positive regulation of autophagosome maturation|negative regulation of autophagosome assembly|regulation of TORC1 signaling|Atg1/ULK1 kinase complex "hsa04140,hsa05014,hsa05022" Autophagy - animal|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases SMDT1 308.7770533 284.03299 333.5211167 1.174233728 0.231719602 0.46110095 1 9.704429349 11.20458387 91689 single-pass membrane protein with aspartate rich tail 1 "GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005759,GO:0006851,GO:0031305,GO:0036444,GO:0051560,GO:1990246" protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|mitochondrial calcium ion transmembrane transport|integral component of mitochondrial inner membrane|calcium import into the mitochondrion|mitochondrial calcium ion homeostasis|uniplex complex SMG1 4099.826514 4731.802338 3467.850689 0.732881562 -0.448348026 0.060160804 1 15.22718247 10.97297845 23049 SMG1 nonsense mediated mRNA decay associated PI3K related kinase "GO:0000184,GO:0003723,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006281,GO:0006406,GO:0016242,GO:0018105,GO:0031931,GO:0031932,GO:0032204,GO:0038202,GO:0042162,GO:0046777,GO:0046854,GO:0046872,GO:0106310,GO:0106311,GO:2001020" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA repair|mRNA export from nucleus|negative regulation of macroautophagy|peptidyl-serine phosphorylation|TORC1 complex|TORC2 complex|regulation of telomere maintenance|TORC1 signaling|telomeric DNA binding|protein autophosphorylation|phosphatidylinositol phosphorylation|metal ion binding|protein serine kinase activity|protein threonine kinase activity|regulation of response to DNA damage stimulus" hsa03015 mRNA surveillance pathway SMG5 2694.984226 2924.603424 2465.365027 0.84297413 -0.246439738 0.297420205 1 31.46788499 26.08272603 23381 SMG5 nonsense mediated mRNA decay factor "GO:0000184,GO:0005515,GO:0005634,GO:0005697,GO:0005737,GO:0005829,GO:0006406,GO:0031625,GO:0032204,GO:0032210,GO:0035303,GO:0042162,GO:0042826,GO:0051721,GO:0070034" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein binding|nucleus|telomerase holoenzyme complex|cytoplasm|cytosol|mRNA export from nucleus|ubiquitin protein ligase binding|regulation of telomere maintenance|regulation of telomere maintenance via telomerase|regulation of dephosphorylation|telomeric DNA binding|histone deacetylase binding|protein phosphatase 2A binding|telomerase RNA binding" hsa03015 mRNA surveillance pathway SMG6 1145.250192 1111.162027 1179.338358 1.061355887 0.085908492 0.726313596 1 4.473496917 4.668521401 23293 SMG6 nonsense mediated mRNA decay factor "GO:0000184,GO:0000781,GO:0003723,GO:0004521,GO:0005515,GO:0005634,GO:0005697,GO:0005730,GO:0005737,GO:0005829,GO:0006406,GO:0032204,GO:0032210,GO:0035145,GO:0035303,GO:0042162,GO:0043021,GO:0046872,GO:0051972,GO:0070034,GO:0070182,GO:0090502,GO:1904354" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|chromosome, telomeric region|RNA binding|endoribonuclease activity|protein binding|nucleus|telomerase holoenzyme complex|nucleolus|cytoplasm|cytosol|mRNA export from nucleus|regulation of telomere maintenance|regulation of telomere maintenance via telomerase|exon-exon junction complex|regulation of dephosphorylation|telomeric DNA binding|ribonucleoprotein complex binding|metal ion binding|regulation of telomerase activity|telomerase RNA binding|DNA polymerase binding|RNA phosphodiester bond hydrolysis, endonucleolytic|negative regulation of telomere capping" hsa03015 mRNA surveillance pathway SMG7 2070.166729 2392.95193 1747.381528 0.730220071 -0.453596772 0.055252857 1 17.94904377 12.88742827 9887 SMG7 nonsense mediated mRNA decay factor "GO:0000184,GO:0005515,GO:0005634,GO:0005697,GO:0005737,GO:0005829,GO:0006406,GO:0035303,GO:0042162,GO:0045111,GO:0051721,GO:0070034" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein binding|nucleus|telomerase holoenzyme complex|cytoplasm|cytosol|mRNA export from nucleus|regulation of dephosphorylation|telomeric DNA binding|intermediate filament cytoskeleton|protein phosphatase 2A binding|telomerase RNA binding" hsa03015 mRNA surveillance pathway SMG8 717.3250134 739.7342706 694.9157562 0.939412684 -0.090169023 0.727962798 1 12.25652234 11.32126247 55181 SMG8 nonsense mediated mRNA decay factor "GO:0000184,GO:0005515,GO:0005575,GO:0005829,GO:0045859" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein binding|cellular_component|cytosol|regulation of protein kinase activity" SMG9 756.8166959 729.3301317 784.3032601 1.075374821 0.104839598 0.682594987 1 6.797591456 7.187636438 56006 SMG9 nonsense mediated mRNA decay factor "GO:0000184,GO:0001654,GO:0001701,GO:0005515,GO:0005829,GO:0007420,GO:0007507,GO:0042802" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|eye development|in utero embryonic development|protein binding|cytosol|brain development|heart development|identical protein binding" SMIM1 47.64138649 39.53572754 55.74704545 1.410042231 0.495738372 0.426915719 1 4.169859912 5.781290113 388588 small integral membrane protein 1 (Vel blood group) "GO:0005515,GO:0005886,GO:0009986,GO:0016021,GO:0042803" protein binding|plasma membrane|cell surface|integral component of membrane|protein homodimerization activity SMIM10 155.8500751 142.5367019 169.1634483 1.186806247 0.247084426 0.544215407 1 5.129414572 5.98575316 644538 small integral membrane protein 10 GO:0016021 integral component of membrane SMIM10L1 476.6264866 464.0245917 489.2283816 1.054315634 0.076306836 0.78897696 1 5.134592498 5.322893869 100129361 small integral membrane protein 10 like 1 SMIM10L2A 5.04355356 6.242483296 3.844623824 0.615880514 -0.699277611 0.760739355 1 0.063699782 0.038574969 399668 small integral membrane protein 10 like 2A SMIM10L2B 7.406814487 5.202069413 9.61155956 1.847641543 0.88568489 0.555147706 1 0.098553384 0.179044275 644596 small integral membrane protein 10 like 2B SMIM11A 7.927021428 6.242483296 9.61155956 1.539701286 0.622650484 0.695278173 1 0.396606977 0.600437766 54065 small integral membrane protein 11A "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane SMIM11B 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.040667708 0 102723553 small integral membrane protein 11B SMIM12 486.7632835 452.5800389 520.9465281 1.151059444 0.202962341 0.463144174 1 2.892618548 3.273859954 113444 small integral membrane protein 12 "GO:0005515,GO:0016021" protein binding|integral component of membrane SMIM13 696.1651055 676.2690237 716.0611872 1.058840731 0.082485598 0.752107597 1 7.385151395 7.688847025 221710 small integral membrane protein 13 GO:0016021 integral component of membrane SMIM14 991.6545521 939.493736 1043.815368 1.111040264 0.1519111 0.538672729 1 7.672387754 8.381688567 201895 small integral membrane protein 14 "GO:0001835,GO:0005515,GO:0005783,GO:0005789,GO:0016021" blastocyst hatching|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane SMIM15 1446.521666 1336.931839 1556.111493 1.16394228 0.219019516 0.360088302 1 24.70553846 28.27463104 643155 small integral membrane protein 15 GO:0016021 integral component of membrane SMIM19 112.4942614 101.9605605 123.0279624 1.206623049 0.270975046 0.555872652 1 1.762126852 2.090643414 114926 small integral membrane protein 19 "GO:0005515,GO:0016021" protein binding|integral component of membrane SMIM20 392.3573782 383.9127227 400.8020336 1.043992579 0.062111457 0.838982419 1 20.716599 21.26606074 389203 small integral membrane protein 20 "GO:0005515,GO:0005576,GO:0005743,GO:0016021,GO:0033617" protein binding|extracellular region|mitochondrial inner membrane|integral component of membrane|mitochondrial cytochrome c oxidase assembly SMIM26 648.4746436 559.7426689 737.2066182 1.317045598 0.397305295 0.125568345 1 55.21707481 71.50647764 388789 small integral membrane protein 26 GO:0016021 integral component of membrane SMIM27 60.21567185 41.61655531 78.81478839 1.893832582 0.9213088 0.101264938 1 1.728403944 3.218533334 100129250 small integral membrane protein 27 GO:0016021 integral component of membrane SMIM29 453.7669493 444.2567279 463.2771708 1.04281408 0.060481967 0.836138309 1 22.15809819 22.72011615 221491 small integral membrane protein 29 GO:0016021 integral component of membrane SMIM3 185.0810434 152.9408407 217.2212461 1.42029588 0.506191508 0.177018525 1 5.366319249 7.494221271 85027 small integral membrane protein 3 "GO:0005515,GO:0016021,GO:0042802" protein binding|integral component of membrane|identical protein binding SMIM30 1104.129306 990.4740163 1217.784596 1.229496762 0.298067936 0.221548057 1 48.098069 58.14685221 401397 small integral membrane protein 30 GO:0016021 integral component of membrane SMIM38 10.92937619 9.363724944 12.49502743 1.334407781 0.416199607 0.772652545 1 0.211927392 0.278065327 107984345 small integral membrane protein 38 GO:0016021 integral component of membrane SMIM4 125.2616612 121.7284243 128.7948981 1.05805114 0.081409361 0.868648325 1 3.446377865 3.585425728 440957 small integral membrane protein 4 GO:0016021 integral component of membrane SMIM7 576.8785857 534.7727357 618.9844357 1.15747194 0.210977219 0.427847663 1 14.51670297 16.52150631 79086 small integral membrane protein 7 GO:0016021 integral component of membrane SMIM8 108.4514928 96.75849109 120.1444945 1.241694586 0.312310364 0.500509034 1 2.118056946 2.585970691 57150 small integral membrane protein 8 GO:0016021 integral component of membrane SMKR1 9.046693237 10.40413883 7.689247648 0.739056617 -0.436243205 0.791668951 1 0.573013176 0.416402661 100287482 small lysine rich protein 1 SMN1 349.5614004 345.417409 353.7053918 1.023994108 0.034207415 0.91932257 1 9.986073819 10.05456784 6606 "survival of motor neuron 1, telomeric" "GO:0000245,GO:0000387,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006353,GO:0007399,GO:0015030,GO:0016604,GO:0030018,GO:0030424,GO:0032797,GO:0034719,GO:0036464,GO:0042802,GO:0043005,GO:0043204,GO:0051170,GO:0097504" "spliceosomal complex assembly|spliceosomal snRNP assembly|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA-templated transcription, termination|nervous system development|Cajal body|nuclear body|Z disc|axon|SMN complex|SMN-Sm protein complex|cytoplasmic ribonucleoprotein granule|identical protein binding|neuron projection|perikaryon|import into nucleus|Gemini of coiled bodies" hsa03013 RNA transport SMN2 320.6185101 216.4060876 424.8309325 1.96311914 0.973147731 0.001702144 0.264245783 6.256335405 12.07641028 6607 "survival of motor neuron 2, centromeric" "GO:0000245,GO:0000387,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006353,GO:0007399,GO:0015030,GO:0016604,GO:0030018,GO:0030424,GO:0032797,GO:0034719,GO:0036464,GO:0042802,GO:0043005,GO:0043204,GO:0051170,GO:0097504" "spliceosomal complex assembly|spliceosomal snRNP assembly|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA-templated transcription, termination|nervous system development|Cajal body|nuclear body|Z disc|axon|SMN complex|SMN-Sm protein complex|cytoplasmic ribonucleoprotein granule|identical protein binding|neuron projection|perikaryon|import into nucleus|Gemini of coiled bodies" hsa03013 RNA transport SMNDC1 640.0173543 577.4297049 702.6050038 1.216780152 0.283068525 0.276770726 1 6.774315691 8.104919894 10285 survival motor neuron domain containing 1 "GO:0000375,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0006915,GO:0015030,GO:0016607" "RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|apoptotic process|Cajal body|nuclear speck" hsa03040 Spliceosome SMO 417.9418675 399.5189309 436.364804 1.0922256 0.127270877 0.661575909 1 4.45406122 4.783433184 6608 "smoothened, frizzled class receptor" "GO:0000122,GO:0001570,GO:0001649,GO:0001701,GO:0001708,GO:0001755,GO:0001947,GO:0002052,GO:0002053,GO:0003140,GO:0003323,GO:0004930,GO:0005113,GO:0005515,GO:0005794,GO:0005886,GO:0005901,GO:0005929,GO:0007186,GO:0007224,GO:0007228,GO:0007371,GO:0007417,GO:0007494,GO:0009952,GO:0010628,GO:0010629,GO:0016021,GO:0021542,GO:0021696,GO:0021794,GO:0021904,GO:0021910,GO:0021938,GO:0021953,GO:0021987,GO:0030335,GO:0030425,GO:0030666,GO:0030857,GO:0031069,GO:0034504,GO:0035264,GO:0040018,GO:0042307,GO:0042475,GO:0043066,GO:0043231,GO:0043392,GO:0045880,GO:0045944,GO:0046622,GO:0048143,GO:0048741,GO:0048745,GO:0048853,GO:0048873,GO:0050679,GO:0050821,GO:0051451,GO:0051799,GO:0060170,GO:0060242,GO:0060413,GO:0060644,GO:0060684,GO:0061053,GO:0061113,GO:0070062,GO:0070986,GO:0071397,GO:0071679,GO:0072285,GO:0090190,GO:0097542,GO:0097731,GO:2000036,GO:2000826" negative regulation of transcription by RNA polymerase II|vasculogenesis|osteoblast differentiation|in utero embryonic development|cell fate specification|neural crest cell migration|heart looping|positive regulation of neuroblast proliferation|positive regulation of mesenchymal cell proliferation|determination of left/right asymmetry in lateral mesoderm|type B pancreatic cell development|G protein-coupled receptor activity|patched binding|protein binding|Golgi apparatus|plasma membrane|caveola|cilium|G protein-coupled receptor signaling pathway|smoothened signaling pathway|positive regulation of hh target transcription factor activity|ventral midline determination|central nervous system development|midgut development|anterior/posterior pattern specification|positive regulation of gene expression|negative regulation of gene expression|integral component of membrane|dentate gyrus development|cerebellar cortex morphogenesis|thalamus development|dorsal/ventral neural tube patterning|smoothened signaling pathway involved in ventral spinal cord patterning|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|central nervous system neuron differentiation|cerebral cortex development|positive regulation of cell migration|dendrite|endocytic vesicle membrane|negative regulation of epithelial cell differentiation|hair follicle morphogenesis|protein localization to nucleus|multicellular organism growth|positive regulation of multicellular organism growth|positive regulation of protein import into nucleus|odontogenesis of dentin-containing tooth|negative regulation of apoptotic process|intracellular membrane-bounded organelle|negative regulation of DNA binding|positive regulation of smoothened signaling pathway|positive regulation of transcription by RNA polymerase II|positive regulation of organ growth|astrocyte activation|skeletal muscle fiber development|smooth muscle tissue development|forebrain morphogenesis|homeostasis of number of cells within a tissue|positive regulation of epithelial cell proliferation|protein stabilization|myoblast migration|negative regulation of hair follicle development|ciliary membrane|contact inhibition|atrial septum morphogenesis|mammary gland epithelial cell differentiation|epithelial-mesenchymal cell signaling|somite development|pancreas morphogenesis|extracellular exosome|left/right axis specification|cellular response to cholesterol|commissural neuron axon guidance|mesenchymal to epithelial transition involved in metanephric renal vesicle formation|positive regulation of branching involved in ureteric bud morphogenesis|ciliary tip|9+0 non-motile cilium|regulation of stem cell population maintenance|regulation of heart morphogenesis "hsa04340,hsa04360,hsa05200,hsa05205,hsa05217" Hedgehog signaling pathway|Axon guidance|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma SMOX 915.4112303 918.6854584 912.1370022 0.992871928 -0.010320461 0.971691151 1 20.03618898 19.56048099 54498 spermine oxidase "GO:0005654,GO:0005829,GO:0006596,GO:0006598,GO:0016491,GO:0031965,GO:0043231,GO:0046208,GO:0046592,GO:0052894,GO:0052895,GO:0052901,GO:0055114" nucleoplasm|cytosol|polyamine biosynthetic process|polyamine catabolic process|oxidoreductase activity|nuclear membrane|intracellular membrane-bounded organelle|spermine catabolic process|polyamine oxidase activity|norspermine:oxygen oxidoreductase activity|N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity|spermine:oxygen oxidoreductase (spermidine-forming) activity|oxidation-reduction process "hsa00330,hsa00410" Arginine and proline metabolism|beta-Alanine metabolism SMPD1 398.2086023 373.5085839 422.9086206 1.132259442 0.17920457 0.540031013 1 8.070229409 8.984688194 6609 sphingomyelin phosphodiesterase 1 "GO:0001778,GO:0004767,GO:0005515,GO:0005615,GO:0005764,GO:0005768,GO:0005886,GO:0006684,GO:0006685,GO:0006687,GO:0007165,GO:0007399,GO:0008081,GO:0008203,GO:0008270,GO:0009615,GO:0010212,GO:0016798,GO:0023021,GO:0034340,GO:0034612,GO:0034644,GO:0035307,GO:0036019,GO:0042060,GO:0042220,GO:0042493,GO:0042599,GO:0043065,GO:0043202,GO:0043407,GO:0045807,GO:0046513,GO:0046718,GO:0061750,GO:0070062,GO:0070555,GO:0071277" "plasma membrane repair|sphingomyelin phosphodiesterase activity|protein binding|extracellular space|lysosome|endosome|plasma membrane|sphingomyelin metabolic process|sphingomyelin catabolic process|glycosphingolipid metabolic process|signal transduction|nervous system development|phosphoric diester hydrolase activity|cholesterol metabolic process|zinc ion binding|response to virus|response to ionizing radiation|hydrolase activity, acting on glycosyl bonds|termination of signal transduction|response to type I interferon|response to tumor necrosis factor|cellular response to UV|positive regulation of protein dephosphorylation|endolysosome|wound healing|response to cocaine|response to drug|lamellar body|positive regulation of apoptotic process|lysosomal lumen|negative regulation of MAP kinase activity|positive regulation of endocytosis|ceramide biosynthetic process|viral entry into host cell|acid sphingomyelin phosphodiesterase activity|extracellular exosome|response to interleukin-1|cellular response to calcium ion" "hsa00600,hsa04071,hsa04142,hsa04217" Sphingolipid metabolism|Sphingolipid signaling pathway|Lysosome|Necroptosis SMPD2 150.5140275 166.4662212 134.5618338 0.808343175 -0.306960188 0.453754566 1 5.213612837 4.143866274 6610 sphingomyelin phosphodiesterase 2 "GO:0004620,GO:0004767,GO:0005515,GO:0005783,GO:0005886,GO:0005887,GO:0005901,GO:0006684,GO:0006685,GO:0006687,GO:0009612,GO:0016020,GO:0030149,GO:0035556,GO:0046513,GO:0046872,GO:0071944,GO:2000304" phospholipase activity|sphingomyelin phosphodiesterase activity|protein binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|caveola|sphingomyelin metabolic process|sphingomyelin catabolic process|glycosphingolipid metabolic process|response to mechanical stimulus|membrane|sphingolipid catabolic process|intracellular signal transduction|ceramide biosynthetic process|metal ion binding|cell periphery|positive regulation of ceramide biosynthetic process "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway SMPD4 2644.391403 2656.176642 2632.606163 0.991126163 -0.012859382 0.958352866 1 24.26900626 23.65114184 55627 sphingomyelin phosphodiesterase 4 "GO:0000139,GO:0004767,GO:0005635,GO:0005640,GO:0005783,GO:0005789,GO:0005794,GO:0005802,GO:0006685,GO:0006687,GO:0007029,GO:0016021,GO:0042383,GO:0046475,GO:0046513,GO:0046872,GO:0050290,GO:0071356" Golgi membrane|sphingomyelin phosphodiesterase activity|nuclear envelope|nuclear outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|sphingomyelin catabolic process|glycosphingolipid metabolic process|endoplasmic reticulum organization|integral component of membrane|sarcolemma|glycerophospholipid catabolic process|ceramide biosynthetic process|metal ion binding|sphingomyelin phosphodiesterase D activity|cellular response to tumor necrosis factor hsa00600 Sphingolipid metabolism SMPDL3A 53.24477596 47.8590386 58.63051332 1.225066676 0.292860272 0.636582397 1 0.95339639 1.14842968 10924 sphingomyelin phosphodiesterase acid like 3A "GO:0004767,GO:0005515,GO:0005615,GO:0006685,GO:0008081,GO:0008270,GO:0009143,GO:0070062" sphingomyelin phosphodiesterase activity|protein binding|extracellular space|sphingomyelin catabolic process|phosphoric diester hydrolase activity|zinc ion binding|nucleoside triphosphate catabolic process|extracellular exosome SMPDL3B 48.80068727 44.73779695 52.86357758 1.18163122 0.240779849 0.715229116 1 0.796654654 0.92559976 27293 sphingomyelin phosphodiesterase acid like 3B "GO:0004767,GO:0005615,GO:0005886,GO:0006685,GO:0006954,GO:0008081,GO:0008150,GO:0008270,GO:0016798,GO:0031225,GO:0034122,GO:0045087,GO:0046466,GO:0050728,GO:0070062" "sphingomyelin phosphodiesterase activity|extracellular space|plasma membrane|sphingomyelin catabolic process|inflammatory response|phosphoric diester hydrolase activity|biological_process|zinc ion binding|hydrolase activity, acting on glycosyl bonds|anchored component of membrane|negative regulation of toll-like receptor signaling pathway|innate immune response|membrane lipid catabolic process|negative regulation of inflammatory response|extracellular exosome" SMS 2681.943109 2292.031783 3071.854435 1.340232041 0.422482803 0.074185285 1 52.45348358 69.12346675 6611 spermine synthase "GO:0005829,GO:0006555,GO:0006595,GO:0006597,GO:0016768,GO:0070062" cytosol|methionine metabolic process|polyamine metabolic process|spermine biosynthetic process|spermine synthase activity|extracellular exosome "hsa00270,hsa00330,hsa00480" Cysteine and methionine metabolism|Arginine and proline metabolism|Glutathione metabolism SMTN 3365.751582 3022.402329 3709.100834 1.227202877 0.29537377 0.213060053 1 29.5800582 35.69328893 6525 smoothelin "GO:0003779,GO:0005737,GO:0005815,GO:0005856,GO:0006939,GO:0007517,GO:0008307,GO:0015629,GO:0030036,GO:0031941" actin binding|cytoplasm|microtubule organizing center|cytoskeleton|smooth muscle contraction|muscle organ development|structural constituent of muscle|actin cytoskeleton|actin cytoskeleton organization|filamentous actin SMU1 1687.363617 1654.258073 1720.469161 1.040024642 0.056617712 0.813723975 1 12.31822422 12.59687771 55234 SMU1 DNA replication regulator and spliceosomal factor "GO:0000381,GO:0000398,GO:0005515,GO:0005634,GO:0005737,GO:0008380,GO:0016032,GO:0016607,GO:0071005,GO:0071011" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|protein binding|nucleus|cytoplasm|RNA splicing|viral process|nuclear speck|U2-type precatalytic spliceosome|precatalytic spliceosome" SMUG1 664.219246 645.0566072 683.3818847 1.05941382 0.083266234 0.751784473 1 10.23349749 10.66009071 23583 single-strand-selective monofunctional uracil-DNA glycosylase 1 "GO:0000703,GO:0001650,GO:0003677,GO:0004844,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006284,GO:0017065,GO:0019104,GO:0045008" oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity|fibrillar center|DNA binding|uracil DNA N-glycosylase activity|protein binding|nucleoplasm|nucleolus|cytosol|base-excision repair|single-strand selective uracil DNA N-glycosylase activity|DNA N-glycosylase activity|depyrimidination hsa03410 Base excision repair SMURF1 1768.684477 1795.754361 1741.614592 0.969851239 -0.044164619 0.854465478 1 16.6642514 15.89139828 57154 SMAD specific E3 ubiquitin protein ligase 1 "GO:0000209,GO:0004842,GO:0005515,GO:0005543,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006511,GO:0006611,GO:0007179,GO:0007398,GO:0016567,GO:0030154,GO:0030424,GO:0030509,GO:0030512,GO:0030514,GO:0030579,GO:0032801,GO:0034394,GO:0043025,GO:0043161,GO:0045732,GO:0048185,GO:0060071,GO:0061630,GO:0061736,GO:0061753,GO:0070062,GO:0070411,GO:0070412,GO:0071211,GO:0072659,GO:1903861,GO:2000060" "protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|phospholipid binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|protein export from nucleus|transforming growth factor beta receptor signaling pathway|ectoderm development|protein ubiquitination|cell differentiation|axon|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|ubiquitin-dependent SMAD protein catabolic process|receptor catabolic process|protein localization to cell surface|neuronal cell body|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of protein catabolic process|activin binding|Wnt signaling pathway, planar cell polarity pathway|ubiquitin protein ligase activity|engulfment of target by autophagosome|substrate localization to autophagosome|extracellular exosome|I-SMAD binding|R-SMAD binding|protein targeting to vacuole involved in autophagy|protein localization to plasma membrane|positive regulation of dendrite extension|positive regulation of ubiquitin-dependent protein catabolic process" "hsa04120,hsa04144,hsa04340,hsa04350" Ubiquitin mediated proteolysis|Endocytosis|Hedgehog signaling pathway|TGF-beta signaling pathway SMURF2 7702.741311 6864.650798 8540.831825 1.244175717 0.315190254 0.200310882 1 62.73181445 76.74334918 64750 SMAD specific E3 ubiquitin protein ligase 2 "GO:0000122,GO:0000151,GO:0000209,GO:0004842,GO:0005160,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006511,GO:0016567,GO:0016579,GO:0016607,GO:0017015,GO:0030509,GO:0030512,GO:0030514,GO:0030579,GO:0042802,GO:0043161,GO:0045121,GO:0045732,GO:0045892,GO:0046332,GO:0060071,GO:0061630,GO:0090263,GO:1901165" "negative regulation of transcription by RNA polymerase II|ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|transforming growth factor beta receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|protein ubiquitination|protein deubiquitination|nuclear speck|regulation of transforming growth factor beta receptor signaling pathway|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|ubiquitin-dependent SMAD protein catabolic process|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|membrane raft|positive regulation of protein catabolic process|negative regulation of transcription, DNA-templated|SMAD binding|Wnt signaling pathway, planar cell polarity pathway|ubiquitin protein ligase activity|positive regulation of canonical Wnt signaling pathway|positive regulation of trophoblast cell migration" "hsa04120,hsa04144,hsa04340,hsa04350" Ubiquitin mediated proteolysis|Endocytosis|Hedgehog signaling pathway|TGF-beta signaling pathway SMYD2 699.1378921 653.3799183 744.8958659 1.140065443 0.189116641 0.462395354 1 19.98262772 22.40028572 56950 SET and MYND domain containing 2 "GO:0000122,GO:0000993,GO:0002039,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007507,GO:0008285,GO:0010452,GO:0016278,GO:0016279,GO:0018024,GO:0018026,GO:0018027,GO:0034968,GO:0043516,GO:0046872,GO:0046975,GO:1901796" "negative regulation of transcription by RNA polymerase II|RNA polymerase II complex binding|p53 binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|heart development|negative regulation of cell population proliferation|histone H3-K36 methylation|lysine N-methyltransferase activity|protein-lysine N-methyltransferase activity|histone-lysine N-methyltransferase activity|peptidyl-lysine monomethylation|peptidyl-lysine dimethylation|histone lysine methylation|regulation of DNA damage response, signal transduction by p53 class mediator|metal ion binding|histone methyltransferase activity (H3-K36 specific)|regulation of signal transduction by p53 class mediator" hsa00310 Lysine degradation SMYD3 452.7862861 393.2764476 512.2961245 1.302636168 0.381434189 0.173260771 1 2.615382081 3.349881579 64754 SET and MYND domain containing 3 "GO:0000978,GO:0000993,GO:0001162,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0006469,GO:0014904,GO:0018024,GO:0033138,GO:0034968,GO:0045184,GO:0045944,GO:0046872,GO:0071549" RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II complex binding|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|negative regulation of protein kinase activity|myotube cell development|histone-lysine N-methyltransferase activity|positive regulation of peptidyl-serine phosphorylation|histone lysine methylation|establishment of protein localization|positive regulation of transcription by RNA polymerase II|metal ion binding|cellular response to dexamethasone stimulus hsa00310 Lysine degradation SMYD4 414.6419883 439.0546585 390.2293181 0.888794392 -0.170078381 0.556585805 1 5.003531961 4.372694764 114826 SET and MYND domain containing 4 "GO:0008168,GO:0032259,GO:0046872" methyltransferase activity|methylation|metal ion binding SMYD5 635.9192511 709.562268 562.2762343 0.792426908 -0.335650224 0.197092943 1 14.8269515 11.55266712 10322 SMYD family member 5 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0008168,GO:0032259,GO:0046872" molecular_function|protein binding|cellular_component|biological_process|methyltransferase activity|methylation|metal ion binding SNAI1 17.13223052 20.80827765 13.45618338 0.64667454 -0.628888283 0.513000638 1 0.651319375 0.414143585 6615 snail family transcriptional repressor 1 "GO:0000122,GO:0000977,GO:0000978,GO:0001227,GO:0001649,GO:0001650,GO:0001707,GO:0001837,GO:0003180,GO:0003198,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005721,GO:0005737,GO:0005829,GO:0006357,GO:0010718,GO:0010957,GO:0016477,GO:0019900,GO:0030335,GO:0031069,GO:0043231,GO:0043518,GO:0045893,GO:0046872,GO:0060021,GO:0060536,GO:0060707,GO:0060806,GO:0060972,GO:0061314,GO:0070828,GO:0070888,GO:1902230,GO:1990837,GO:2000810" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|osteoblast differentiation|fibrillar center|mesoderm formation|epithelial to mesenchymal transition|aortic valve morphogenesis|epithelial to mesenchymal transition involved in endocardial cushion formation|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|pericentric heterochromatin|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|positive regulation of epithelial to mesenchymal transition|negative regulation of vitamin D biosynthetic process|cell migration|kinase binding|positive regulation of cell migration|hair follicle morphogenesis|intracellular membrane-bounded organelle|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of transcription, DNA-templated|metal ion binding|roof of mouth development|cartilage morphogenesis|trophoblast giant cell differentiation|negative regulation of cell differentiation involved in embryonic placenta development|left/right pattern formation|Notch signaling involved in heart development|heterochromatin organization|E-box binding|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|sequence-specific double-stranded DNA binding|regulation of bicellular tight junction assembly" hsa04520 Adherens junction zf-C2H2 SNAI2 1368.277389 1213.122587 1523.43219 1.255794102 0.328599942 0.170752691 1 29.69822149 36.67077257 6591 snail family transcriptional repressor 2 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001649,GO:0001837,GO:0003180,GO:0003198,GO:0003273,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0007219,GO:0007605,GO:0010839,GO:0010957,GO:0014032,GO:0030335,GO:0032331,GO:0032642,GO:0033629,GO:0035921,GO:0043473,GO:0043518,GO:0043565,GO:0045667,GO:0046872,GO:0060429,GO:0061314,GO:0070563,GO:0070888,GO:0071364,GO:0090090,GO:1902230,GO:1990837,GO:2000810,GO:2000811,GO:2001240" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|osteoblast differentiation|epithelial to mesenchymal transition|aortic valve morphogenesis|epithelial to mesenchymal transition involved in endocardial cushion formation|cell migration involved in endocardial cushion formation|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|Notch signaling pathway|sensory perception of sound|negative regulation of keratinocyte proliferation|negative regulation of vitamin D biosynthetic process|neural crest cell development|positive regulation of cell migration|negative regulation of chondrocyte differentiation|regulation of chemokine production|negative regulation of cell adhesion mediated by integrin|desmosome disassembly|pigmentation|negative regulation of DNA damage response, signal transduction by p53 class mediator|sequence-specific DNA binding|regulation of osteoblast differentiation|metal ion binding|epithelium development|Notch signaling involved in heart development|negative regulation of vitamin D receptor signaling pathway|E-box binding|cellular response to epidermal growth factor stimulus|negative regulation of canonical Wnt signaling pathway|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|sequence-specific double-stranded DNA binding|regulation of bicellular tight junction assembly|negative regulation of anoikis|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa04390,hsa04520" Hippo signaling pathway|Adherens junction zf-C2H2 SNAI3 36.31069026 32.25283036 40.36855015 1.251628142 0.323806002 0.65739431 1 0.989238091 1.217439333 333929 snail family transcriptional repressor 3 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0005507,GO:0005634,GO:0005667,GO:0006355,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|copper ion binding|nucleus|transcription regulator complex|regulation of transcription, DNA-templated|sequence-specific double-stranded DNA binding" SNAP23 1480.309965 1466.983575 1493.636356 1.018168425 0.025976231 0.916283097 1 20.72814858 20.75158704 8773 synaptosome associated protein 23 "GO:0002479,GO:0002553,GO:0005484,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005886,GO:0005912,GO:0005925,GO:0006887,GO:0006892,GO:0006903,GO:0006906,GO:0015031,GO:0016082,GO:0019905,GO:0030670,GO:0031201,GO:0031629,GO:0035579,GO:0042581,GO:0042582,GO:0043005,GO:0043312,GO:0061025,GO:0070062,GO:0070821,GO:0098793" "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|histamine secretion by mast cell|SNAP receptor activity|protein binding|nucleoplasm|cytoplasm|mitochondrion|plasma membrane|adherens junction|focal adhesion|exocytosis|post-Golgi vesicle-mediated transport|vesicle targeting|vesicle fusion|protein transport|synaptic vesicle priming|syntaxin binding|phagocytic vesicle membrane|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|specific granule membrane|specific granule|azurophil granule|neuron projection|neutrophil degranulation|membrane fusion|extracellular exosome|tertiary granule membrane|presynapse" "hsa04130,hsa04611" SNARE interactions in vesicular transport|Platelet activation SNAP25 65.65551504 58.26317743 73.04785266 1.253756762 0.326257481 0.561859904 1 1.013493708 1.249411571 6616 synaptosome associated protein 25 "GO:0001504,GO:0001917,GO:0005249,GO:0005484,GO:0005515,GO:0005737,GO:0005802,GO:0005829,GO:0005856,GO:0005886,GO:0006887,GO:0006906,GO:0007268,GO:0007269,GO:0007626,GO:0008021,GO:0008076,GO:0008306,GO:0010975,GO:0014047,GO:0016020,GO:0016079,GO:0016081,GO:0016082,GO:0017075,GO:0019905,GO:0030426,GO:0031083,GO:0031201,GO:0031234,GO:0031629,GO:0031982,GO:0035579,GO:0036477,GO:0042734,GO:0043005,GO:0043312,GO:0048306,GO:0048471,GO:0050796,GO:0060291,GO:0070032,GO:0070821,GO:0071805,GO:0098794,GO:0098967,GO:0098978,GO:0099590" neurotransmitter uptake|photoreceptor inner segment|voltage-gated potassium channel activity|SNAP receptor activity|protein binding|cytoplasm|trans-Golgi network|cytosol|cytoskeleton|plasma membrane|exocytosis|vesicle fusion|chemical synaptic transmission|neurotransmitter secretion|locomotory behavior|synaptic vesicle|voltage-gated potassium channel complex|associative learning|regulation of neuron projection development|glutamate secretion|membrane|synaptic vesicle exocytosis|synaptic vesicle docking|synaptic vesicle priming|syntaxin-1 binding|syntaxin binding|growth cone|BLOC-1 complex|SNARE complex|extrinsic component of cytoplasmic side of plasma membrane|synaptic vesicle fusion to presynaptic active zone membrane|vesicle|specific granule membrane|somatodendritic compartment|presynaptic membrane|neuron projection|neutrophil degranulation|calcium-dependent protein binding|perinuclear region of cytoplasm|regulation of insulin secretion|long-term synaptic potentiation|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex|tertiary granule membrane|potassium ion transmembrane transport|postsynapse|exocytic insertion of neurotransmitter receptor to postsynaptic membrane|glutamatergic synapse|neurotransmitter receptor internalization "hsa04721,hsa04911" Synaptic vesicle cycle|Insulin secretion SNAP29 1123.653751 1137.172374 1110.135129 0.976224146 -0.034715659 0.89018327 1 14.24954204 13.67796949 9342 synaptosome associated protein 29 "GO:0000139,GO:0000421,GO:0005484,GO:0005515,GO:0005654,GO:0005737,GO:0005776,GO:0005813,GO:0005829,GO:0005886,GO:0006887,GO:0006903,GO:0006906,GO:0015031,GO:0016082,GO:0016240,GO:0019905,GO:0020018,GO:0031201,GO:0031629,GO:0035577,GO:0043312,GO:0060271,GO:0061025,GO:0097352,GO:0098793" Golgi membrane|autophagosome membrane|SNAP receptor activity|protein binding|nucleoplasm|cytoplasm|autophagosome|centrosome|cytosol|plasma membrane|exocytosis|vesicle targeting|vesicle fusion|protein transport|synaptic vesicle priming|autophagosome membrane docking|syntaxin binding|ciliary pocket membrane|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|azurophil granule membrane|neutrophil degranulation|cilium assembly|membrane fusion|autophagosome maturation|presynapse "hsa04130,hsa04140" SNARE interactions in vesicular transport|Autophagy - animal SNAP47 637.1137648 627.3695712 646.8579584 1.031063647 0.044133393 0.871147905 1 4.707756041 4.772771063 116841 synaptosome associated protein 47 "GO:0005484,GO:0005515,GO:0005886,GO:0006887,GO:0006906,GO:0012505,GO:0016082,GO:0019905,GO:0031083,GO:0031201,GO:0031629,GO:0048471,GO:0098793" SNAP receptor activity|protein binding|plasma membrane|exocytosis|vesicle fusion|endomembrane system|synaptic vesicle priming|syntaxin binding|BLOC-1 complex|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|perinuclear region of cytoplasm|presynapse SNAPC1 1821.755646 1876.906644 1766.604647 0.941232028 -0.087377682 0.713923251 1 38.62979483 35.75117146 6617 small nuclear RNA activating complex polypeptide 1 "GO:0000995,GO:0005515,GO:0005654,GO:0005730,GO:0016251,GO:0019185,GO:0042795,GO:0042796,GO:0043565" RNA polymerase III general transcription initiation factor activity|protein binding|nucleoplasm|nucleolus|RNA polymerase II general transcription initiation factor activity|snRNA-activating protein complex|snRNA transcription by RNA polymerase II|snRNA transcription by RNA polymerase III|sequence-specific DNA binding other SNAPC2 635.0876573 586.7934298 683.3818847 1.164603845 0.219839287 0.399822995 1 20.60268873 23.59246391 6618 small nuclear RNA activating complex polypeptide 2 "GO:0005634,GO:0005654,GO:0005829,GO:0006366,GO:0006383,GO:0009301,GO:0016251,GO:0016604,GO:0042795" nucleus|nucleoplasm|cytosol|transcription by RNA polymerase II|transcription by RNA polymerase III|snRNA transcription|RNA polymerase II general transcription initiation factor activity|nuclear body|snRNA transcription by RNA polymerase II other SNAPC3 1053.718308 966.544497 1140.89212 1.180382407 0.239254323 0.328749305 1 6.279087446 7.287699184 6619 small nuclear RNA activating complex polypeptide 3 "GO:0000978,GO:0000995,GO:0001006,GO:0001046,GO:0003677,GO:0003681,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006366,GO:0006383,GO:0009301,GO:0016604,GO:0019185,GO:0042795,GO:0042796" RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase III general transcription initiation factor activity|RNA polymerase III type 3 promoter sequence-specific DNA binding|core promoter sequence-specific DNA binding|DNA binding|bent DNA binding|protein binding|nucleus|nucleoplasm|nucleolus|transcription by RNA polymerase II|transcription by RNA polymerase III|snRNA transcription|nuclear body|snRNA-activating protein complex|snRNA transcription by RNA polymerase II|snRNA transcription by RNA polymerase III SNAPC4 440.9397989 473.3883166 408.4912813 0.862909512 -0.212718814 0.452880038 1 4.44082693 3.767907937 6621 small nuclear RNA activating complex polypeptide 4 "GO:0000995,GO:0003677,GO:0005634,GO:0005654,GO:0016251,GO:0019185,GO:0042795,GO:0042796" RNA polymerase III general transcription initiation factor activity|DNA binding|nucleus|nucleoplasm|RNA polymerase II general transcription initiation factor activity|snRNA-activating protein complex|snRNA transcription by RNA polymerase II|snRNA transcription by RNA polymerase III MYB SNAPC5 213.5930456 258.0226429 169.1634483 0.655614741 -0.609079802 0.085517616 1 5.694869407 3.671162918 10302 small nuclear RNA activating complex polypeptide 5 "GO:0000995,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006384,GO:0016251,GO:0016604,GO:0042795,GO:0042796" RNA polymerase III general transcription initiation factor activity|protein binding|nucleus|nucleoplasm|nucleolus|transcription initiation from RNA polymerase III promoter|RNA polymerase II general transcription initiation factor activity|nuclear body|snRNA transcription by RNA polymerase II|snRNA transcription by RNA polymerase III other SNAPIN 653.8000159 661.7032294 645.8968024 0.976112514 -0.034880642 0.898816013 1 35.20826041 33.79213462 23557 SNAP associated protein "GO:0000139,GO:0000149,GO:0001669,GO:0002177,GO:0005515,GO:0005765,GO:0006886,GO:0007040,GO:0007042,GO:0007269,GO:0008021,GO:0008089,GO:0008090,GO:0008333,GO:0010977,GO:0016032,GO:0016079,GO:0016188,GO:0030141,GO:0030672,GO:0031083,GO:0031175,GO:0031629,GO:0032418,GO:0032438,GO:0034629,GO:0043393,GO:0045202,GO:0048471,GO:0048489,GO:0048490,GO:0051604,GO:0072553,GO:0097352,GO:0099078,GO:1902774,GO:1902824,GO:1904115,GO:2000300" Golgi membrane|SNARE binding|acrosomal vesicle|manchette|protein binding|lysosomal membrane|intracellular protein transport|lysosome organization|lysosomal lumen acidification|neurotransmitter secretion|synaptic vesicle|anterograde axonal transport|retrograde axonal transport|endosome to lysosome transport|negative regulation of neuron projection development|viral process|synaptic vesicle exocytosis|synaptic vesicle maturation|secretory granule|synaptic vesicle membrane|BLOC-1 complex|neuron projection development|synaptic vesicle fusion to presynaptic active zone membrane|lysosome localization|melanosome organization|cellular protein-containing complex localization|regulation of protein binding|synapse|perinuclear region of cytoplasm|synaptic vesicle transport|anterograde synaptic vesicle transport|protein maturation|terminal button organization|autophagosome maturation|BORC complex|late endosome to lysosome transport|positive regulation of late endosome to lysosome transport|axon cytoplasm|regulation of synaptic vesicle exocytosis SNCA 417.8921777 423.4484502 412.3359051 0.97375703 -0.038366257 0.901713264 1 5.112820254 4.895333788 6622 synuclein alpha "GO:0000122,GO:0000149,GO:0000287,GO:0000976,GO:0001774,GO:0001921,GO:0003779,GO:0004860,GO:0005504,GO:0005507,GO:0005509,GO:0005515,GO:0005543,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005739,GO:0005764,GO:0005829,GO:0005886,GO:0005938,GO:0006469,GO:0006915,GO:0006919,GO:0007268,GO:0008198,GO:0008270,GO:0010040,GO:0010517,GO:0010642,GO:0014059,GO:0015629,GO:0016020,GO:0016079,GO:0016082,GO:0016234,GO:0016491,GO:0019894,GO:0022898,GO:0030424,GO:0030426,GO:0030544,GO:0031092,GO:0031115,GO:0031623,GO:0031648,GO:0032026,GO:0032410,GO:0032496,GO:0032769,GO:0032991,GO:0033138,GO:0034341,GO:0034599,GO:0035067,GO:0035493,GO:0035543,GO:0042393,GO:0042416,GO:0042802,GO:0043014,GO:0043025,GO:0043027,GO:0043065,GO:0043066,GO:0043154,GO:0043679,GO:0044267,GO:0045807,GO:0045920,GO:0045921,GO:0048156,GO:0048471,GO:0048488,GO:0050729,GO:0050808,GO:0051219,GO:0051262,GO:0051281,GO:0051583,GO:0051585,GO:0051612,GO:0051621,GO:0051622,GO:0055074,GO:0055114,GO:0060732,GO:0060961,GO:0070495,GO:0070555,GO:0070840,GO:0071280,GO:0071872,GO:0071902,GO:0097435,GO:0099512,GO:1901214,GO:1901215,GO:1901216,GO:1902957,GO:1903136,GO:1903284,GO:1903285,GO:1903421,GO:1903426,GO:1904715,GO:1905606" "negative regulation of transcription by RNA polymerase II|SNARE binding|magnesium ion binding|transcription regulatory region sequence-specific DNA binding|microglial cell activation|positive regulation of receptor recycling|actin binding|protein kinase inhibitor activity|fatty acid binding|copper ion binding|calcium ion binding|protein binding|phospholipid binding|extracellular region|extracellular space|nucleus|cytoplasm|mitochondrion|lysosome|cytosol|plasma membrane|cell cortex|negative regulation of protein kinase activity|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|chemical synaptic transmission|ferrous iron binding|zinc ion binding|response to iron(II) ion|regulation of phospholipase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|regulation of dopamine secretion|actin cytoskeleton|membrane|synaptic vesicle exocytosis|synaptic vesicle priming|inclusion body|oxidoreductase activity|kinesin binding|regulation of transmembrane transporter activity|axon|growth cone|Hsp70 protein binding|platelet alpha granule membrane|negative regulation of microtubule polymerization|receptor internalization|protein destabilization|response to magnesium ion|negative regulation of transporter activity|response to lipopolysaccharide|negative regulation of monooxygenase activity|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|response to interferon-gamma|cellular response to oxidative stress|negative regulation of histone acetylation|SNARE complex assembly|positive regulation of SNARE complex assembly|histone binding|dopamine biosynthetic process|identical protein binding|alpha-tubulin binding|neuronal cell body|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|axon terminus|cellular protein metabolic process|positive regulation of endocytosis|negative regulation of exocytosis|positive regulation of exocytosis|tau protein binding|perinuclear region of cytoplasm|synaptic vesicle endocytosis|positive regulation of inflammatory response|synapse organization|phosphoprotein binding|protein tetramerization|positive regulation of release of sequestered calcium ion into cytosol|dopamine uptake involved in synaptic transmission|negative regulation of dopamine uptake involved in synaptic transmission|negative regulation of serotonin uptake|regulation of norepinephrine uptake|negative regulation of norepinephrine uptake|calcium ion homeostasis|oxidation-reduction process|positive regulation of inositol phosphate biosynthetic process|phospholipase D inhibitor activity|negative regulation of thrombin-activated receptor signaling pathway|response to interleukin-1|dynein complex binding|cellular response to copper ion|cellular response to epinephrine stimulus|positive regulation of protein serine/threonine kinase activity|supramolecular fiber organization|supramolecular fiber|regulation of neuron death|negative regulation of neuron death|positive regulation of neuron death|negative regulation of mitochondrial electron transport, NADH to ubiquinone|cuprous ion binding|positive regulation of glutathione peroxidase activity|positive regulation of hydrogen peroxide catabolic process|regulation of synaptic vesicle recycling|regulation of reactive oxygen species biosynthetic process|negative regulation of chaperone-mediated autophagy|regulation of presynapse assembly" "hsa05010,hsa05012,hsa05022" Alzheimer disease|Parkinson disease|Pathways of neurodegeneration - multiple diseases SNCAIP 12.25222323 6.242483296 18.26196316 2.925432444 1.548649903 0.150303853 1 0.040303637 0.115932576 9627 synuclein alpha interacting protein "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0008021,GO:0008219,GO:0031625,GO:0036464,GO:0042417,GO:0042734,GO:0042802,GO:0043025,GO:0044267,GO:0046928,GO:0090083" protein binding|nucleoplasm|cytoplasm|cytosol|synaptic vesicle|cell death|ubiquitin protein ligase binding|cytoplasmic ribonucleoprotein granule|dopamine metabolic process|presynaptic membrane|identical protein binding|neuronal cell body|cellular protein metabolic process|regulation of neurotransmitter secretion|regulation of inclusion body assembly "hsa05012,hsa05022" Parkinson disease|Pathways of neurodegeneration - multiple diseases SNCB 2.923096831 1.040413883 4.80577978 4.619103859 2.207612985 0.416510993 1 0.028621122 0.129991681 6620 synuclein beta "GO:0004859,GO:0005509,GO:0005515,GO:0005737,GO:0005829,GO:0007268,GO:0010038,GO:0016234,GO:0042417,GO:0043025,GO:0043086,GO:0043524,GO:0043679,GO:0046914,GO:0048488,GO:0050808,GO:1901214,GO:1903136" phospholipase inhibitor activity|calcium ion binding|protein binding|cytoplasm|cytosol|chemical synaptic transmission|response to metal ion|inclusion body|dopamine metabolic process|neuronal cell body|negative regulation of catalytic activity|negative regulation of neuron apoptotic process|axon terminus|transition metal ion binding|synaptic vesicle endocytosis|synapse organization|regulation of neuron death|cuprous ion binding SNCG 70.13420228 74.90979955 65.35860501 0.872497396 -0.19677727 0.730520326 1 3.946493903 3.385686595 6623 synuclein gamma "GO:0005515,GO:0005737,GO:0005813,GO:0005819,GO:0007268,GO:0008344,GO:0009306,GO:0014059,GO:0043025,GO:0043679,GO:0046928,GO:0048471,GO:0048488,GO:0050808,GO:0070062,GO:1901214,GO:1903136" protein binding|cytoplasm|centrosome|spindle|chemical synaptic transmission|adult locomotory behavior|protein secretion|regulation of dopamine secretion|neuronal cell body|axon terminus|regulation of neurotransmitter secretion|perinuclear region of cytoplasm|synaptic vesicle endocytosis|synapse organization|extracellular exosome|regulation of neuron death|cuprous ion binding SND1 7308.931524 6606.628155 8011.234893 1.21260569 0.278110497 0.256653775 1 43.62578596 52.01565177 27044 staphylococcal nuclease and tudor domain containing 1 "GO:0001649,GO:0003712,GO:0003723,GO:0004518,GO:0004519,GO:0004521,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006355,GO:0006401,GO:0010564,GO:0010587,GO:0016020,GO:0016032,GO:0016442,GO:0031047,GO:0042470,GO:0045296,GO:0070062,GO:0090502,GO:0097433,GO:1905172" "osteoblast differentiation|transcription coregulator activity|RNA binding|nuclease activity|endonuclease activity|endoribonuclease activity|protein binding|nucleus|cytoplasm|cytosol|regulation of transcription, DNA-templated|RNA catabolic process|regulation of cell cycle process|miRNA catabolic process|membrane|viral process|RISC complex|gene silencing by RNA|melanosome|cadherin binding|extracellular exosome|RNA phosphodiester bond hydrolysis, endonucleolytic|dense body|RISC complex binding" hsa05203 Viral carcinogenesis SNED1 5.603389465 8.323311061 2.883467868 0.346432789 -1.529352609 0.352439314 1 0.041576171 0.014162328 25992 "sushi, nidogen and EGF like domains 1" "GO:0005112,GO:0005509,GO:0005576,GO:0007160" Notch binding|calcium ion binding|extracellular region|cell-matrix adhesion SNF8 1181.169623 1120.525752 1241.813495 1.108241817 0.14827271 0.542266572 1 28.80558763 31.38935929 11267 SNF8 subunit of ESCRT-II "GO:0000814,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0005886,GO:0006357,GO:0008022,GO:0008134,GO:0010008,GO:0010628,GO:0010797,GO:0016020,GO:0016197,GO:0016236,GO:0016247,GO:0031902,GO:0032456,GO:0036258,GO:0042176,GO:0042803,GO:0043328,GO:0043405,GO:0045022,GO:0045732,GO:0047485,GO:0048471,GO:0055037,GO:0061635,GO:0070062,GO:0071985,GO:1903543,GO:1903772" ESCRT II complex|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|protein C-terminus binding|transcription factor binding|endosome membrane|positive regulation of gene expression|regulation of multivesicular body size involved in endosome transport|membrane|endosomal transport|macroautophagy|channel regulator activity|late endosome membrane|endocytic recycling|multivesicular body assembly|regulation of protein catabolic process|protein homodimerization activity|protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|regulation of MAP kinase activity|early endosome to late endosome transport|positive regulation of protein catabolic process|protein N-terminus binding|perinuclear region of cytoplasm|recycling endosome|regulation of protein complex stability|extracellular exosome|multivesicular body sorting pathway|positive regulation of exosomal secretion|regulation of viral budding via host ESCRT complex hsa04144 Endocytosis SNIP1 295.870645 311.0837509 280.6575392 0.902192861 -0.148492225 0.644980234 1 3.645579279 3.233978377 79753 Smad nuclear interacting protein 1 "GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007249,GO:0035196,GO:0071005" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|I-kappaB kinase/NF-kappaB signaling|production of miRNAs involved in gene silencing by miRNA|U2-type precatalytic spliceosome" SNN 745.6740837 752.2192372 739.1289302 0.98259775 -0.025327159 0.926075381 1 11.68351518 11.28809021 8303 stannin "GO:0005737,GO:0005741,GO:0009636,GO:0016021,GO:0046872" cytoplasm|mitochondrial outer membrane|response to toxic substance|integral component of membrane|metal ion binding SNORC 62.48961401 63.46524684 61.51398118 0.96925458 -0.045052447 0.966973776 1 0.680535178 0.648574127 389084 secondary ossification center associated regulator of chondrocyte maturation "GO:0005515,GO:0005737,GO:0016021,GO:0051216,GO:0062023,GO:0071944" protein binding|cytoplasm|integral component of membrane|cartilage development|collagen-containing extracellular matrix|cell periphery SNPH 743.3108227 753.259651 733.3619944 0.973584598 -0.03862175 0.884370469 1 7.060077826 6.758562928 9751 syntaphilin "GO:0005515,GO:0005737,GO:0005739,GO:0005881,GO:0007269,GO:0007420,GO:0008017,GO:0016021,GO:0016081,GO:0017075,GO:0030182,GO:0031966,GO:0042734,GO:0043005,GO:0043025" protein binding|cytoplasm|mitochondrion|cytoplasmic microtubule|neurotransmitter secretion|brain development|microtubule binding|integral component of membrane|synaptic vesicle docking|syntaxin-1 binding|neuron differentiation|mitochondrial membrane|presynaptic membrane|neuron projection|neuronal cell body SNRK 843.4886943 809.4420007 877.5353878 1.084123862 0.116529595 0.644103991 1 8.203272291 8.744544847 54861 SNF related kinase "GO:0000287,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0030099,GO:0035556,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|myeloid cell differentiation|intracellular signal transduction|protein serine kinase activity|protein threonine kinase activity SNRNP200 7126.883863 7870.731022 6383.036704 0.810983972 -0.302254694 0.216880001 1 58.3884416 46.55971716 23020 small nuclear ribonucleoprotein U5 subunit 200 "GO:0000354,GO:0000388,GO:0000398,GO:0001649,GO:0003723,GO:0003724,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0016020,GO:0042802,GO:0046540,GO:0071005,GO:0071006,GO:0071013" "cis assembly of pre-catalytic spliceosome|spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)|mRNA splicing, via spliceosome|osteoblast differentiation|RNA binding|RNA helicase activity|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|spliceosomal complex|U5 snRNP|membrane|identical protein binding|U4/U6 x U5 tri-snRNP complex|U2-type precatalytic spliceosome|U2-type catalytic step 1 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SNRNP25 546.7116135 461.9437639 631.4794631 1.367005061 0.451018584 0.092328708 1 22.67993529 30.48478329 79622 small nuclear ribonucleoprotein U11/U12 subunit 25 "GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005689,GO:0005829,GO:0008380,GO:0045171" "mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|U12-type spliceosomal complex|cytosol|RNA splicing|intercellular bridge" SNRNP27 547.7419665 488.9945248 606.4894082 1.240278525 0.310664139 0.246634278 1 18.31350109 22.33375674 11017 small nuclear ribonucleoprotein U4/U6.U5 subunit 27 "GO:0000398,GO:0003676,GO:0005515,GO:0005575,GO:0005654,GO:0008150" "mRNA splicing, via spliceosome|nucleic acid binding|protein binding|cellular_component|nucleoplasm|biological_process" hsa03040 Spliceosome SNRNP35 287.4435383 253.8609874 321.0260893 1.264574335 0.338651845 0.291598636 1 5.076093788 6.311683016 11066 small nuclear ribonucleoprotein U11/U12 subunit 35 "GO:0000398,GO:0003729,GO:0005634,GO:0005654,GO:0005689,GO:0005730,GO:0008380,GO:0017069" "mRNA splicing, via spliceosome|mRNA binding|nucleus|nucleoplasm|U12-type spliceosomal complex|nucleolus|RNA splicing|snRNA binding" SNRNP40 917.1995641 953.0191165 881.3800116 0.92482931 -0.112740974 0.651843041 1 31.49280413 28.63809304 9410 small nuclear ribonucleoprotein U5 subunit 40 "GO:0000375,GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005682,GO:0005732,GO:0005829,GO:0006396,GO:0008380,GO:0016607,GO:0071007,GO:0071013" "RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|U5 snRNP|sno(s)RNA-containing ribonucleoprotein complex|cytosol|RNA processing|RNA splicing|nuclear speck|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SNRNP48 484.82085 502.5199053 467.1217946 0.929558789 -0.105381985 0.707200839 1 6.589327704 6.022671098 154007 small nuclear ribonucleoprotein U11/U12 subunit 48 "GO:0000398,GO:0005515,GO:0005654,GO:0005689,GO:0005829,GO:0008380,GO:0046872" "mRNA splicing, via spliceosome|protein binding|nucleoplasm|U12-type spliceosomal complex|cytosol|RNA splicing|metal ion binding" SNRNP70 3171.168419 2796.632517 3545.704322 1.267847778 0.342381541 0.148542444 1 76.1485395 94.92921084 6625 small nuclear ribonucleoprotein U1 subunit 70 "GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005685,GO:0016607,GO:0017069,GO:0030619,GO:0043462,GO:0043484,GO:0048026,GO:0061084,GO:0071004,GO:1904715" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U1 snRNP|nuclear speck|snRNA binding|U1 snRNA binding|regulation of ATPase activity|regulation of RNA splicing|positive regulation of mRNA splicing, via spliceosome|negative regulation of protein refolding|U2-type prespliceosome|negative regulation of chaperone-mediated autophagy" hsa03040 Spliceosome SNRPA 1943.981582 1780.148153 2107.815011 1.184067184 0.243750942 0.303348176 1 74.39564226 86.6153812 6626 small nuclear ribonucleoprotein polypeptide A "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005681,GO:0005685,GO:0030619,GO:0042802,GO:1900363,GO:1990446" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|spliceosomal complex|U1 snRNP|U1 snRNA binding|identical protein binding|regulation of mRNA polyadenylation|U1 snRNP binding" hsa03040 Spliceosome SNRPA1 1235.495057 1070.585885 1400.404228 1.308072755 0.387442785 0.108812588 1 54.31102761 69.85397085 6627 small nuclear ribonucleoprotein polypeptide A' "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005686,GO:0007283,GO:0008380,GO:0016604,GO:0016607,GO:0030532,GO:0030620,GO:0035722,GO:0071005,GO:0071007,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U2 snRNP|spermatogenesis|RNA splicing|nuclear body|nuclear speck|small nuclear ribonucleoprotein complex|U2 snRNA binding|interleukin-12-mediated signaling pathway|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SNRPB 4003.46604 3451.052849 4555.879231 1.320141832 0.400692937 0.092687771 1 170.218436 220.952219 6628 small nuclear ribonucleoprotein polypeptides B and B1 "GO:0000387,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0005683,GO:0005685,GO:0005686,GO:0005687,GO:0005689,GO:0005697,GO:0005737,GO:0005829,GO:0006369,GO:0006479,GO:0007420,GO:0008334,GO:0008380,GO:0030532,GO:0034709,GO:0034719,GO:0046540,GO:0051170,GO:0070034,GO:0071004,GO:0071005,GO:0071007,GO:0071013,GO:0071204,GO:0071208,GO:1990446,GO:1990447" "spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U5 snRNP|U7 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|U12-type spliceosomal complex|telomerase holoenzyme complex|cytoplasm|cytosol|termination of RNA polymerase II transcription|protein methylation|brain development|histone mRNA metabolic process|RNA splicing|small nuclear ribonucleoprotein complex|methylosome|SMN-Sm protein complex|U4/U6 x U5 tri-snRNP complex|import into nucleus|telomerase RNA binding|U2-type prespliceosome|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|histone pre-mRNA 3'end processing complex|histone pre-mRNA DCP binding|U1 snRNP binding|U2 snRNP binding" "hsa03040,hsa05322" Spliceosome|Systemic lupus erythematosus SNRPB2 1484.240106 1254.739142 1713.74107 1.365814624 0.449761686 0.059731959 1 28.97582082 38.91335574 6629 small nuclear ribonucleoprotein polypeptide B2 "GO:0000398,GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005685,GO:0005686,GO:0016607,GO:0030619,GO:0036464,GO:0070990,GO:0071005,GO:0071007,GO:0071013" "mRNA splicing, via spliceosome|fibrillar center|protein binding|nucleus|nucleoplasm|spliceosomal complex|U1 snRNP|U2 snRNP|nuclear speck|U1 snRNA binding|cytoplasmic ribonucleoprotein granule|snRNP binding|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SNRPC 1195.517766 1093.474991 1297.560541 1.186639431 0.246881628 0.30843607 1 72.40291629 84.47846487 6631 small nuclear ribonucleoprotein polypeptide C "GO:0000243,GO:0000387,GO:0000395,GO:0000398,GO:0003723,GO:0003727,GO:0003729,GO:0005515,GO:0005654,GO:0005685,GO:0008270,GO:0015030,GO:0030619,GO:0030627,GO:0042803,GO:0071004" "commitment complex|spliceosomal snRNP assembly|mRNA 5'-splice site recognition|mRNA splicing, via spliceosome|RNA binding|single-stranded RNA binding|mRNA binding|protein binding|nucleoplasm|U1 snRNP|zinc ion binding|Cajal body|U1 snRNA binding|pre-mRNA 5'-splice site binding|protein homodimerization activity|U2-type prespliceosome" hsa03040 Spliceosome SNRPD1 1334.617423 1162.142307 1507.092539 1.296822713 0.374981264 0.11860373 1 12.76685858 16.27930405 6632 small nuclear ribonucleoprotein D1 polypeptide "GO:0000243,GO:0000245,GO:0000387,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005682,GO:0005685,GO:0005686,GO:0005687,GO:0005689,GO:0005829,GO:0008380,GO:0030532,GO:0034709,GO:0034715,GO:0034719,GO:0046540,GO:0051170,GO:0071005,GO:0071007,GO:0071011,GO:0071013,GO:0097526,GO:1990446" "commitment complex|spliceosomal complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|U5 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|U12-type spliceosomal complex|cytosol|RNA splicing|small nuclear ribonucleoprotein complex|methylosome|pICln-Sm protein complex|SMN-Sm protein complex|U4/U6 x U5 tri-snRNP complex|import into nucleus|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|precatalytic spliceosome|catalytic step 2 spliceosome|spliceosomal tri-snRNP complex|U1 snRNP binding" "hsa03040,hsa05322" Spliceosome|Systemic lupus erythematosus SNRPD2 2266.863974 2043.372866 2490.355082 1.21874726 0.285398976 0.227377673 1 123.5006277 147.9973694 6633 small nuclear ribonucleoprotein D2 polypeptide "GO:0000245,GO:0000387,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0005685,GO:0005686,GO:0005687,GO:0005689,GO:0005829,GO:0008380,GO:0030532,GO:0034709,GO:0034715,GO:0034719,GO:0046540,GO:0051170,GO:0070062,GO:0071005,GO:0071007,GO:0071011,GO:0071013,GO:1990446" "spliceosomal complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U5 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|U12-type spliceosomal complex|cytosol|RNA splicing|small nuclear ribonucleoprotein complex|methylosome|pICln-Sm protein complex|SMN-Sm protein complex|U4/U6 x U5 tri-snRNP complex|import into nucleus|extracellular exosome|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|precatalytic spliceosome|catalytic step 2 spliceosome|U1 snRNP binding" hsa03040 Spliceosome SNRPD3 1892.583662 1919.563613 1865.603711 0.971889495 -0.041135808 0.864171756 1 29.67658808 28.35972629 6634 small nuclear ribonucleoprotein D3 polypeptide "GO:0000243,GO:0000387,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0005683,GO:0005685,GO:0005686,GO:0005687,GO:0005689,GO:0005697,GO:0005829,GO:0006369,GO:0006479,GO:0008334,GO:0008380,GO:0016604,GO:0019899,GO:0030532,GO:0034709,GO:0034715,GO:0034719,GO:0046540,GO:0051170,GO:0070034,GO:0071005,GO:0071007,GO:0071011,GO:0071013,GO:0071208,GO:0071209,GO:0097526" "commitment complex|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U5 snRNP|U7 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|U12-type spliceosomal complex|telomerase holoenzyme complex|cytosol|termination of RNA polymerase II transcription|protein methylation|histone mRNA metabolic process|RNA splicing|nuclear body|enzyme binding|small nuclear ribonucleoprotein complex|methylosome|pICln-Sm protein complex|SMN-Sm protein complex|U4/U6 x U5 tri-snRNP complex|import into nucleus|telomerase RNA binding|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|precatalytic spliceosome|catalytic step 2 spliceosome|histone pre-mRNA DCP binding|U7 snRNA binding|spliceosomal tri-snRNP complex" "hsa03040,hsa05322" Spliceosome|Systemic lupus erythematosus SNRPE 964.3458957 929.0895972 999.6021942 1.075894292 0.105536338 0.671445671 1 29.46155924 31.16710829 6635 small nuclear ribonucleoprotein polypeptide E "GO:0000245,GO:0000387,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0005683,GO:0005685,GO:0005686,GO:0005687,GO:0005689,GO:0005697,GO:0005829,GO:0006369,GO:0008334,GO:0030532,GO:0034709,GO:0034715,GO:0034719,GO:0042633,GO:0046540,GO:0051170,GO:0071005,GO:0071007,GO:0071011,GO:0071013" "spliceosomal complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U5 snRNP|U7 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|U12-type spliceosomal complex|telomerase holoenzyme complex|cytosol|termination of RNA polymerase II transcription|histone mRNA metabolic process|small nuclear ribonucleoprotein complex|methylosome|pICln-Sm protein complex|SMN-Sm protein complex|hair cycle|U4/U6 x U5 tri-snRNP complex|import into nucleus|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|precatalytic spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SNRPF 783.1050601 687.7135764 878.4965438 1.277416317 0.353228784 0.161594655 1 25.9012065 32.53296396 6636 small nuclear ribonucleoprotein polypeptide F "GO:0000387,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005683,GO:0005685,GO:0005687,GO:0005689,GO:0005732,GO:0005829,GO:0006369,GO:0008334,GO:0008380,GO:0030532,GO:0034709,GO:0034715,GO:0034719,GO:0046540,GO:0051170,GO:0071005,GO:0071007,GO:0071013" "spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U7 snRNP|U1 snRNP|U4 snRNP|U12-type spliceosomal complex|sno(s)RNA-containing ribonucleoprotein complex|cytosol|termination of RNA polymerase II transcription|histone mRNA metabolic process|RNA splicing|small nuclear ribonucleoprotein complex|methylosome|pICln-Sm protein complex|SMN-Sm protein complex|U4/U6 x U5 tri-snRNP complex|import into nucleus|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" hsa03040 Spliceosome SNRPG 1260.202678 1075.787955 1444.617402 1.342845861 0.425293714 0.077953255 1 36.59198593 48.31514905 6637 small nuclear ribonucleoprotein polypeptide G "GO:0000245,GO:0000387,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0005683,GO:0005685,GO:0005686,GO:0005687,GO:0005689,GO:0005829,GO:0006369,GO:0008334,GO:0008380,GO:0030532,GO:0034709,GO:0034719,GO:0043186,GO:0046540,GO:0051170,GO:0071004,GO:0071005,GO:0071007,GO:0071011,GO:0071013,GO:0097526,GO:1990904" "spliceosomal complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U5 snRNP|U7 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|U12-type spliceosomal complex|cytosol|termination of RNA polymerase II transcription|histone mRNA metabolic process|RNA splicing|small nuclear ribonucleoprotein complex|methylosome|SMN-Sm protein complex|P granule|U4/U6 x U5 tri-snRNP complex|import into nucleus|U2-type prespliceosome|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|precatalytic spliceosome|catalytic step 2 spliceosome|spliceosomal tri-snRNP complex|ribonucleoprotein complex" hsa03040 Spliceosome SNRPN 9.928591267 8.323311061 11.53387147 1.385731158 0.470647391 0.750315201 1 0.131071057 0.178589929 6638 small nuclear ribonucleoprotein polypeptide N "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005681,GO:0005682,GO:0005685,GO:0005686,GO:0005687,GO:0005737,GO:0008380,GO:0009725,GO:0030532,GO:0046540,GO:0071004,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|spliceosomal complex|U5 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|cytoplasm|RNA splicing|response to hormone|small nuclear ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|U2-type prespliceosome|catalytic step 2 spliceosome" SNTA1 1009.024556 966.544497 1051.504616 1.087900887 0.121547126 0.622979274 1 20.64960103 22.08880263 6640 syntrophin alpha 1 "GO:0002027,GO:0003117,GO:0003779,GO:0005198,GO:0005515,GO:0005516,GO:0005622,GO:0005737,GO:0005856,GO:0006936,GO:0007528,GO:0016010,GO:0016013,GO:0016328,GO:0017080,GO:0030165,GO:0031594,GO:0032991,GO:0042383,GO:0044325,GO:0045202,GO:0045211,GO:0050998,GO:0051117,GO:0060307,GO:0086005,GO:1902083,GO:1902305" regulation of heart rate|regulation of vasoconstriction by circulating norepinephrine|actin binding|structural molecule activity|protein binding|calmodulin binding|intracellular anatomical structure|cytoplasm|cytoskeleton|muscle contraction|neuromuscular junction development|dystrophin-associated glycoprotein complex|syntrophin complex|lateral plasma membrane|sodium channel regulator activity|PDZ domain binding|neuromuscular junction|protein-containing complex|sarcolemma|ion channel binding|synapse|postsynaptic membrane|nitric-oxide synthase binding|ATPase binding|regulation of ventricular cardiac muscle cell membrane repolarization|ventricular cardiac muscle cell action potential|negative regulation of peptidyl-cysteine S-nitrosylation|regulation of sodium ion transmembrane transport SNTB1 6.723061274 12.48496659 0.961155956 0.076985064 -3.699277611 0.029231409 0.88444427 0.129655521 0.009814511 6641 syntrophin beta 1 "GO:0003779,GO:0005198,GO:0005515,GO:0005516,GO:0005622,GO:0005737,GO:0005856,GO:0005925,GO:0006936,GO:0016010,GO:0030165,GO:0032991,GO:0042383,GO:0045202" actin binding|structural molecule activity|protein binding|calmodulin binding|intracellular anatomical structure|cytoplasm|cytoskeleton|focal adhesion|muscle contraction|dystrophin-associated glycoprotein complex|PDZ domain binding|protein-containing complex|sarcolemma|synapse SNTB2 994.1807449 1031.050158 957.3113322 0.928481825 -0.107054425 0.665904367 1 5.631486227 5.141236851 6645 syntrophin beta 2 "GO:0003723,GO:0003779,GO:0005198,GO:0005515,GO:0005516,GO:0005622,GO:0005654,GO:0005737,GO:0005794,GO:0005874,GO:0005886,GO:0005925,GO:0016010,GO:0016020,GO:0030658,GO:0032991,GO:0045202" RNA binding|actin binding|structural molecule activity|protein binding|calmodulin binding|intracellular anatomical structure|nucleoplasm|cytoplasm|Golgi apparatus|microtubule|plasma membrane|focal adhesion|dystrophin-associated glycoprotein complex|membrane|transport vesicle membrane|protein-containing complex|synapse SNTG2 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.013575789 0 54221 syntrophin gamma 2 "GO:0003779,GO:0005198,GO:0005515,GO:0005622,GO:0005654,GO:0005737,GO:0005856,GO:0005886,GO:0007417,GO:0016010,GO:0016013,GO:0030165,GO:0042383,GO:0097109" actin binding|structural molecule activity|protein binding|intracellular anatomical structure|nucleoplasm|cytoplasm|cytoskeleton|plasma membrane|central nervous system development|dystrophin-associated glycoprotein complex|syntrophin complex|PDZ domain binding|sarcolemma|neuroligin family protein binding SNU13 1614.495017 1507.559716 1721.430317 1.141865426 0.191392633 0.421682038 1 30.32630654 34.04909887 4809 small nuclear ribonucleoprotein 13 "GO:0000398,GO:0000470,GO:0001651,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005690,GO:0005730,GO:0006364,GO:0030490,GO:0030515,GO:0030621,GO:0030622,GO:0031428,GO:0032040,GO:0032991,GO:0034511,GO:0034512,GO:0046540,GO:0051117,GO:0071005,GO:0071011" "mRNA splicing, via spliceosome|maturation of LSU-rRNA|dense fibrillar component|RNA binding|protein binding|nucleus|nucleoplasm|U4atac snRNP|nucleolus|rRNA processing|maturation of SSU-rRNA|snoRNA binding|U4 snRNA binding|U4atac snRNA binding|box C/D RNP complex|small-subunit processome|protein-containing complex|U3 snoRNA binding|box C/D RNA binding|U4/U6 x U5 tri-snRNP complex|ATPase binding|U2-type precatalytic spliceosome|precatalytic spliceosome" "hsa03008,hsa03040" Ribosome biogenesis in eukaryotes|Spliceosome SNUPN 482.3739151 413.0443114 551.7035187 1.335700562 0.41759662 0.129822793 1 10.44216758 13.71421475 10073 snurportin 1 "GO:0000339,GO:0000387,GO:0005515,GO:0005643,GO:0005829,GO:0006606,GO:0051170,GO:0061015,GO:0061608" RNA cap binding|spliceosomal snRNP assembly|protein binding|nuclear pore|cytosol|protein import into nucleus|import into nucleus|snRNA import into nucleus|nuclear import signal receptor activity hsa03013 RNA transport SNW1 2020.728791 2041.292038 2000.165544 0.979852715 -0.029363186 0.903298499 1 49.31643473 47.51422512 22938 SNW domain containing 1 "GO:0000122,GO:0000398,GO:0003713,GO:0003714,GO:0003723,GO:0005112,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0006357,GO:0006367,GO:0007219,GO:0007221,GO:0008024,GO:0016032,GO:0016363,GO:0016604,GO:0016607,GO:0019899,GO:0030511,GO:0035257,GO:0042771,GO:0042809,GO:0042974,GO:0043923,GO:0045747,GO:0045892,GO:0045944,GO:0046332,GO:0048026,GO:0048384,GO:0048385,GO:0050681,GO:0050769,GO:0051571,GO:0070562,GO:0070564,GO:0071007,GO:0071013,GO:0071300" "negative regulation of transcription by RNA polymerase II|mRNA splicing, via spliceosome|transcription coactivator activity|transcription corepressor activity|RNA binding|Notch binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|Notch signaling pathway|positive regulation of transcription of Notch receptor target|cyclin/CDK positive transcription elongation factor complex|viral process|nuclear matrix|nuclear body|nuclear speck|enzyme binding|positive regulation of transforming growth factor beta receptor signaling pathway|nuclear hormone receptor binding|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|vitamin D receptor binding|retinoic acid receptor binding|positive regulation by host of viral transcription|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|SMAD binding|positive regulation of mRNA splicing, via spliceosome|retinoic acid receptor signaling pathway|regulation of retinoic acid receptor signaling pathway|androgen receptor binding|positive regulation of neurogenesis|positive regulation of histone H3-K4 methylation|regulation of vitamin D receptor signaling pathway|positive regulation of vitamin D receptor signaling pathway|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|cellular response to retinoic acid" "hsa03040,hsa04330,hsa05169,hsa05203" Spliceosome|Notch signaling pathway|Epstein-Barr virus infection|Viral carcinogenesis SNX1 2014.11014 1968.463066 2059.757214 1.04637839 0.065404651 0.783867797 1 12.38251485 12.73998151 6642 sorting nexin 1 "GO:0005154,GO:0005158,GO:0005515,GO:0005737,GO:0005764,GO:0005768,GO:0005794,GO:0005829,GO:0006886,GO:0010008,GO:0016020,GO:0030027,GO:0030904,GO:0030905,GO:0031623,GO:0031901,GO:0031982,GO:0032991,GO:0034498,GO:0035091,GO:0042147,GO:0042802,GO:0042803,GO:0043231,GO:0045296,GO:0045732,GO:0046982,GO:0072673,GO:1990459,GO:1990460" "epidermal growth factor receptor binding|insulin receptor binding|protein binding|cytoplasm|lysosome|endosome|Golgi apparatus|cytosol|intracellular protein transport|endosome membrane|membrane|lamellipodium|retromer complex|retromer, tubulation complex|receptor internalization|early endosome membrane|vesicle|protein-containing complex|early endosome to Golgi transport|phosphatidylinositol binding|retrograde transport, endosome to Golgi|identical protein binding|protein homodimerization activity|intracellular membrane-bounded organelle|cadherin binding|positive regulation of protein catabolic process|protein heterodimerization activity|lamellipodium morphogenesis|transferrin receptor binding|leptin receptor binding" hsa04144 Endocytosis SNX10 310.2980452 286.1138177 334.4822727 1.169053195 0.225340578 0.473074803 1 3.65996371 4.207094147 29887 sorting nexin 10 "GO:0001696,GO:0005515,GO:0005545,GO:0005634,GO:0005783,GO:0005813,GO:0006886,GO:0006897,GO:0007032,GO:0030141,GO:0030316,GO:0031313,GO:0035630,GO:0044691,GO:0045453,GO:0051117,GO:0055074,GO:0060271,GO:0061512,GO:0071539,GO:0090651,GO:0097178,GO:1990830" gastric acid secretion|protein binding|1-phosphatidylinositol binding|nucleus|endoplasmic reticulum|centrosome|intracellular protein transport|endocytosis|endosome organization|secretory granule|osteoclast differentiation|extrinsic component of endosome membrane|bone mineralization involved in bone maturation|tooth eruption|bone resorption|ATPase binding|calcium ion homeostasis|cilium assembly|protein localization to cilium|protein localization to centrosome|apical cytoplasm|ruffle assembly|cellular response to leukemia inhibitory factor SNX11 323.5309317 343.3365813 303.7252821 0.884628375 -0.176856576 0.570091331 1 5.980170469 5.201703677 29916 sorting nexin 11 "GO:0005515,GO:0005768,GO:0006886,GO:0016020,GO:0016050,GO:1901981" protein binding|endosome|intracellular protein transport|membrane|vesicle organization|phosphatidylinositol phosphate binding SNX12 1799.991857 1721.884976 1878.098738 1.090722531 0.12528414 0.59833109 1 37.72324978 40.45708259 29934 sorting nexin 12 "GO:0005515,GO:0005769,GO:0010629,GO:0010955,GO:0015031,GO:0019899,GO:0030100,GO:0030904,GO:0031901,GO:0032266,GO:0032456,GO:0033157,GO:0034499,GO:0035091,GO:0042177,GO:0051224,GO:2000642" protein binding|early endosome|negative regulation of gene expression|negative regulation of protein processing|protein transport|enzyme binding|regulation of endocytosis|retromer complex|early endosome membrane|phosphatidylinositol-3-phosphate binding|endocytic recycling|regulation of intracellular protein transport|late endosome to Golgi transport|phosphatidylinositol binding|negative regulation of protein catabolic process|negative regulation of protein transport|negative regulation of early endosome to late endosome transport hsa04144 Endocytosis SNX13 948.5560195 956.1403581 940.9716809 0.984135512 -0.023071112 0.930074319 1 4.103534669 3.970856465 23161 sorting nexin 13 "GO:0005769,GO:0006886,GO:0009968,GO:0031901,GO:0032266,GO:0035091,GO:0043547" early endosome|intracellular protein transport|negative regulation of signal transduction|early endosome membrane|phosphatidylinositol-3-phosphate binding|phosphatidylinositol binding|positive regulation of GTPase activity SNX14 1716.54551 1587.671585 1845.419436 1.162343304 0.217036239 0.360969701 1 21.12468573 24.14325678 57231 sorting nexin 14 "GO:0005764,GO:0005765,GO:0005770,GO:0005829,GO:0015031,GO:0016021,GO:0030425,GO:0031902,GO:0043231,GO:0080025,GO:0097352" "lysosome|lysosomal membrane|late endosome|cytosol|protein transport|integral component of membrane|dendrite|late endosome membrane|intracellular membrane-bounded organelle|phosphatidylinositol-3,5-bisphosphate binding|autophagosome maturation" SNX15 677.4275947 663.7840571 691.0711324 1.041108362 0.058120237 0.82661581 1 18.56652785 19.00630992 29907 sorting nexin 15 "GO:0005515,GO:0005730,GO:0005769,GO:0005829,GO:0005886,GO:0006886,GO:0016020,GO:0030659,GO:0035091,GO:0043231" protein binding|nucleolus|early endosome|cytosol|plasma membrane|intracellular protein transport|membrane|cytoplasmic vesicle membrane|phosphatidylinositol binding|intracellular membrane-bounded organelle SNX16 480.5509828 365.1852728 595.9166927 1.631820167 0.706482075 0.010580796 0.6183435 5.845610926 9.379363786 64089 sorting nexin 16 "GO:0005764,GO:0005769,GO:0005770,GO:0005829,GO:0006622,GO:0008333,GO:0031313,GO:0031901,GO:0031902,GO:0035091,GO:0042802,GO:0043231,GO:0045022" lysosome|early endosome|late endosome|cytosol|protein targeting to lysosome|endosome to lysosome transport|extrinsic component of endosome membrane|early endosome membrane|late endosome membrane|phosphatidylinositol binding|identical protein binding|intracellular membrane-bounded organelle|early endosome to late endosome transport SNX17 1573.428236 1451.377366 1695.479106 1.168186266 0.224270329 0.346684786 1 39.72171411 45.62588023 9784 sorting nexin 17 "GO:0001822,GO:0003279,GO:0005102,GO:0005515,GO:0005768,GO:0005769,GO:0005794,GO:0005829,GO:0006707,GO:0006886,GO:0006898,GO:0007165,GO:0008022,GO:0010008,GO:0016020,GO:0016197,GO:0030100,GO:0030659,GO:0031410,GO:0032456,GO:0032991,GO:0035091,GO:0035904,GO:0043231,GO:0050750,GO:0060976,GO:1990126" "kidney development|cardiac septum development|signaling receptor binding|protein binding|endosome|early endosome|Golgi apparatus|cytosol|cholesterol catabolic process|intracellular protein transport|receptor-mediated endocytosis|signal transduction|protein C-terminus binding|endosome membrane|membrane|endosomal transport|regulation of endocytosis|cytoplasmic vesicle membrane|cytoplasmic vesicle|endocytic recycling|protein-containing complex|phosphatidylinositol binding|aorta development|intracellular membrane-bounded organelle|low-density lipoprotein particle receptor binding|coronary vasculature development|retrograde transport, endosome to plasma membrane" SNX18 438.284044 504.6007331 371.967355 0.737151832 -0.439966291 0.118839417 1 3.554595262 2.576429634 112574 sorting nexin 18 "GO:0000281,GO:0005515,GO:0005546,GO:0006897,GO:0010008,GO:0015031,GO:0016197,GO:0030136,GO:0030659,GO:0031234,GO:0031410,GO:0036089,GO:0043547,GO:0070062" "mitotic cytokinesis|protein binding|phosphatidylinositol-4,5-bisphosphate binding|endocytosis|endosome membrane|protein transport|endosomal transport|clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic vesicle|cleavage furrow formation|positive regulation of GTPase activity|extracellular exosome" hsa05132 Salmonella infection SNX19 1280.955007 1355.659289 1206.250725 0.889789001 -0.16846483 0.485384786 1 1.849318661 1.617968133 399979 sorting nexin 19 "GO:0002062,GO:0005515,GO:0005737,GO:0006887,GO:0030073,GO:0030659,GO:0031901,GO:0032266,GO:1990502" chondrocyte differentiation|protein binding|cytoplasm|exocytosis|insulin secretion|cytoplasmic vesicle membrane|early endosome membrane|phosphatidylinositol-3-phosphate binding|dense core granule maturation SNX2 1654.833384 1582.469515 1727.197253 1.091456888 0.126255146 0.596513156 1 11.8714492 12.74035422 6643 sorting nexin 2 "GO:0005154,GO:0005158,GO:0005515,GO:0005737,GO:0005764,GO:0005768,GO:0005829,GO:0006886,GO:0006897,GO:0010008,GO:0016020,GO:0030027,GO:0030904,GO:0030905,GO:0031901,GO:0032991,GO:0034498,GO:0035091,GO:0042147,GO:0042802,GO:0042803,GO:0045296,GO:0046982,GO:0072673,GO:1990459,GO:1990460" "epidermal growth factor receptor binding|insulin receptor binding|protein binding|cytoplasm|lysosome|endosome|cytosol|intracellular protein transport|endocytosis|endosome membrane|membrane|lamellipodium|retromer complex|retromer, tubulation complex|early endosome membrane|protein-containing complex|early endosome to Golgi transport|phosphatidylinositol binding|retrograde transport, endosome to Golgi|identical protein binding|protein homodimerization activity|cadherin binding|protein heterodimerization activity|lamellipodium morphogenesis|transferrin receptor binding|leptin receptor binding" hsa04144 Endocytosis SNX21 821.9218215 861.4626948 782.3809482 0.908200614 -0.138917083 0.582057536 1 9.248577896 8.259008791 90203 sorting nexin family member 21 "GO:0005546,GO:0015031,GO:0030659,GO:0031901,GO:0032266" "phosphatidylinositol-4,5-bisphosphate binding|protein transport|cytoplasmic vesicle membrane|early endosome membrane|phosphatidylinositol-3-phosphate binding" SNX22 17.41466368 15.60620824 19.22311912 1.231761029 0.300722389 0.792076496 1 0.229252588 0.277659083 79856 sorting nexin 22 "GO:0015031,GO:0030659,GO:1901981" protein transport|cytoplasmic vesicle membrane|phosphatidylinositol phosphate binding SNX24 1055.28396 957.180772 1153.387147 1.204983615 0.26901353 0.27188122 1 8.74109832 10.35662677 28966 sorting nexin 24 "GO:0005515,GO:0015031,GO:0030659,GO:1901981" protein binding|protein transport|cytoplasmic vesicle membrane|phosphatidylinositol phosphate binding SNX25 502.2160064 467.1458333 537.2861794 1.150146573 0.201817728 0.462322474 1 2.092029416 2.365876961 83891 sorting nexin 25 "GO:0003674,GO:0010008,GO:0015031,GO:0030512,GO:0032801,GO:0035091,GO:0043231,GO:0060394" molecular_function|endosome membrane|protein transport|negative regulation of transforming growth factor beta receptor signaling pathway|receptor catabolic process|phosphatidylinositol binding|intracellular membrane-bounded organelle|negative regulation of pathway-restricted SMAD protein phosphorylation SNX27 742.6616681 774.0679287 711.2554074 0.918853993 -0.122092461 0.633894825 1 5.534643981 5.000430272 81609 sorting nexin 27 "GO:0001770,GO:0001772,GO:0005515,GO:0005654,GO:0005768,GO:0005769,GO:0005829,GO:0006886,GO:0007165,GO:0008333,GO:0016197,GO:0030904,GO:0031901,GO:0032266,GO:0035091,GO:0071203,GO:1990126" "establishment of natural killer cell polarity|immunological synapse|protein binding|nucleoplasm|endosome|early endosome|cytosol|intracellular protein transport|signal transduction|endosome to lysosome transport|endosomal transport|retromer complex|early endosome membrane|phosphatidylinositol-3-phosphate binding|phosphatidylinositol binding|WASH complex|retrograde transport, endosome to plasma membrane" SNX29 247.2831938 234.0931236 260.4732641 1.112690796 0.15405274 0.654633414 1 0.908524454 0.993990641 92017 sorting nexin 29 GO:0035091 phosphatidylinositol binding SNX3 2990.674889 2688.429473 3292.920305 1.224849057 0.292603971 0.21652032 1 93.47005853 112.570933 8724 sorting nexin 3 "GO:0005515,GO:0005737,GO:0005769,GO:0005829,GO:0009617,GO:0010008,GO:0010314,GO:0010324,GO:0010976,GO:0015031,GO:0016055,GO:0016579,GO:0019903,GO:0022615,GO:0030111,GO:0030136,GO:0030904,GO:0031901,GO:0032009,GO:0032266,GO:0032456,GO:0033157,GO:0034499,GO:0042177,GO:0046597,GO:0050765,GO:0051224,GO:0070062,GO:0070273,GO:0070676,GO:0080025,GO:2000642" "protein binding|cytoplasm|early endosome|cytosol|response to bacterium|endosome membrane|phosphatidylinositol-5-phosphate binding|membrane invagination|positive regulation of neuron projection development|protein transport|Wnt signaling pathway|protein deubiquitination|protein phosphatase binding|protein to membrane docking|regulation of Wnt signaling pathway|clathrin-coated vesicle|retromer complex|early endosome membrane|early phagosome|phosphatidylinositol-3-phosphate binding|endocytic recycling|regulation of intracellular protein transport|late endosome to Golgi transport|negative regulation of protein catabolic process|negative regulation of viral entry into host cell|negative regulation of phagocytosis|negative regulation of protein transport|extracellular exosome|phosphatidylinositol-4-phosphate binding|intralumenal vesicle formation|phosphatidylinositol-3,5-bisphosphate binding|negative regulation of early endosome to late endosome transport" hsa04144 Endocytosis SNX30 1038.919156 1019.605605 1058.232708 1.037884357 0.053645705 0.830207944 1 6.57417871 6.709059607 401548 sorting nexin family member 30 "GO:0005515,GO:0015031,GO:0035091" protein binding|protein transport|phosphatidylinositol binding SNX33 1211.52971 1211.041759 1212.017661 1.000805836 0.001162108 1 1 14.93324235 14.69518714 257364 sorting nexin 33 "GO:0000281,GO:0005515,GO:0005829,GO:0006886,GO:0006897,GO:0007032,GO:0016020,GO:0016197,GO:0017038,GO:0019898,GO:0030659,GO:0031410,GO:0035091,GO:0036089,GO:0042802,GO:0044351,GO:0045806,GO:0051044,GO:0097320,GO:2000009,GO:2000010" mitotic cytokinesis|protein binding|cytosol|intracellular protein transport|endocytosis|endosome organization|membrane|endosomal transport|protein import|extrinsic component of membrane|cytoplasmic vesicle membrane|cytoplasmic vesicle|phosphatidylinositol binding|cleavage furrow formation|identical protein binding|macropinocytosis|negative regulation of endocytosis|positive regulation of membrane protein ectodomain proteolysis|plasma membrane tubulation|negative regulation of protein localization to cell surface|positive regulation of protein localization to cell surface hsa05132 Salmonella infection SNX4 465.1819339 441.1354862 489.2283816 1.109020691 0.149286282 0.59560436 1 9.006346644 9.82108536 8723 sorting nexin 4 "GO:0005154,GO:0005158,GO:0005515,GO:0005737,GO:0005868,GO:0005886,GO:0015031,GO:0016020,GO:0031201,GO:0031901,GO:0032456,GO:0032991,GO:0035091,GO:1903595,GO:1990459,GO:1990460" epidermal growth factor receptor binding|insulin receptor binding|protein binding|cytoplasm|cytoplasmic dynein complex|plasma membrane|protein transport|membrane|SNARE complex|early endosome membrane|endocytic recycling|protein-containing complex|phosphatidylinositol binding|positive regulation of histamine secretion by mast cell|transferrin receptor binding|leptin receptor binding hsa04144 Endocytosis SNX5 3014.57484 2710.278164 3318.871516 1.224550144 0.292251852 0.217120659 1 61.78665713 74.39477786 27131 sorting nexin 5 "GO:0001726,GO:0001891,GO:0005515,GO:0005768,GO:0005829,GO:0005903,GO:0006886,GO:0006907,GO:0007174,GO:0010314,GO:0016241,GO:0030659,GO:0030904,GO:0030905,GO:0031234,GO:0031313,GO:0031748,GO:0031901,GO:0034452,GO:0035091,GO:0035815,GO:0042147,GO:0043231,GO:0045296,GO:0045776,GO:0045893,GO:0046628,GO:0048471,GO:0070273,GO:0070685,GO:0080025,GO:0097422" "ruffle|phagocytic cup|protein binding|endosome|cytosol|brush border|intracellular protein transport|pinocytosis|epidermal growth factor catabolic process|phosphatidylinositol-5-phosphate binding|regulation of macroautophagy|cytoplasmic vesicle membrane|retromer complex|retromer, tubulation complex|extrinsic component of cytoplasmic side of plasma membrane|extrinsic component of endosome membrane|D1 dopamine receptor binding|early endosome membrane|dynactin binding|phosphatidylinositol binding|positive regulation of renal sodium excretion|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|cadherin binding|negative regulation of blood pressure|positive regulation of transcription, DNA-templated|positive regulation of insulin receptor signaling pathway|perinuclear region of cytoplasm|phosphatidylinositol-4-phosphate binding|macropinocytic cup|phosphatidylinositol-3,5-bisphosphate binding|tubular endosome" hsa04144 Endocytosis SNX6 3558.73388 3344.930633 3772.537127 1.127837179 0.173558807 0.46504253 1 51.9234439 57.58124826 58533 sorting nexin 6 "GO:0005515,GO:0005634,GO:0005737,GO:0005768,GO:0005829,GO:0006886,GO:0007175,GO:0016241,GO:0030512,GO:0030904,GO:0030905,GO:0031901,GO:0034452,GO:0035091,GO:0042147,GO:0042803,GO:0043524,GO:0045892,GO:0097422,GO:1903593,GO:1904646" "protein binding|nucleus|cytoplasm|endosome|cytosol|intracellular protein transport|negative regulation of epidermal growth factor-activated receptor activity|regulation of macroautophagy|negative regulation of transforming growth factor beta receptor signaling pathway|retromer complex|retromer, tubulation complex|early endosome membrane|dynactin binding|phosphatidylinositol binding|retrograde transport, endosome to Golgi|protein homodimerization activity|negative regulation of neuron apoptotic process|negative regulation of transcription, DNA-templated|tubular endosome|regulation of histamine secretion by mast cell|cellular response to amyloid-beta" hsa04144 Endocytosis SNX7 1320.095674 1222.486312 1417.705035 1.159689905 0.213739088 0.374541415 1 27.18410318 30.99759968 51375 sorting nexin 7 "GO:0005515,GO:0015031,GO:0030659,GO:0035091" protein binding|protein transport|cytoplasmic vesicle membrane|phosphatidylinositol binding SNX8 1183.487611 1231.850037 1135.125184 0.92148001 -0.117975226 0.628354003 1 11.70820524 10.60833983 29886 sorting nexin 8 "GO:0005515,GO:0005829,GO:0006886,GO:0030904,GO:0031901,GO:0034498,GO:0035091,GO:0042802,GO:0043231" protein binding|cytosol|intracellular protein transport|retromer complex|early endosome membrane|early endosome to Golgi transport|phosphatidylinositol binding|identical protein binding|intracellular membrane-bounded organelle SNX9 2385.910877 2481.38711 2290.434643 0.923046079 -0.115525425 0.625859951 1 45.83837642 41.60291746 51429 sorting nexin 9 "GO:0000281,GO:0001726,GO:0005515,GO:0005545,GO:0005737,GO:0005802,GO:0005829,GO:0005886,GO:0006886,GO:0006897,GO:0006898,GO:0016197,GO:0030136,GO:0030659,GO:0030838,GO:0031234,GO:0031410,GO:0031625,GO:0032437,GO:0035091,GO:0036089,GO:0042802,GO:0042803,GO:0043547,GO:0045296,GO:0045860,GO:0051044,GO:0060988,GO:0061024,GO:0065003,GO:0070062,GO:0071933,GO:0097320" mitotic cytokinesis|ruffle|protein binding|1-phosphatidylinositol binding|cytoplasm|trans-Golgi network|cytosol|plasma membrane|intracellular protein transport|endocytosis|receptor-mediated endocytosis|endosomal transport|clathrin-coated vesicle|cytoplasmic vesicle membrane|positive regulation of actin filament polymerization|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic vesicle|ubiquitin protein ligase binding|cuticular plate|phosphatidylinositol binding|cleavage furrow formation|identical protein binding|protein homodimerization activity|positive regulation of GTPase activity|cadherin binding|positive regulation of protein kinase activity|positive regulation of membrane protein ectodomain proteolysis|lipid tube assembly|membrane organization|protein-containing complex assembly|extracellular exosome|Arp2/3 complex binding|plasma membrane tubulation hsa05132 Salmonella infection SOAT1 1691.137815 1829.047606 1553.228025 0.849200436 -0.235822982 0.32095255 1 13.31872139 11.12100207 6646 sterol O-acyltransferase 1 "GO:0000062,GO:0004772,GO:0005515,GO:0005783,GO:0005789,GO:0008203,GO:0008374,GO:0010742,GO:0010878,GO:0015485,GO:0016020,GO:0016021,GO:0033344,GO:0034379,GO:0034383,GO:0034435,GO:0034736,GO:0042632,GO:0042986" fatty-acyl-CoA binding|sterol O-acyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol metabolic process|O-acyltransferase activity|macrophage derived foam cell differentiation|cholesterol storage|cholesterol binding|membrane|integral component of membrane|cholesterol efflux|very-low-density lipoprotein particle assembly|low-density lipoprotein particle clearance|cholesterol esterification|cholesterol O-acyltransferase activity|cholesterol homeostasis|positive regulation of amyloid precursor protein biosynthetic process "hsa00100,hsa04979" Steroid biosynthesis|Cholesterol metabolism SOBP 70.01531539 71.7885579 68.24207288 0.950598185 -0.073092447 0.918250134 1 0.412891841 0.385926375 55084 sine oculis binding protein homolog "GO:0005634,GO:0007605,GO:0007626,GO:0032184,GO:0042472,GO:0046872,GO:0050890,GO:0090102" nucleus|sensory perception of sound|locomotory behavior|SUMO polymer binding|inner ear morphogenesis|metal ion binding|cognition|cochlea development SOCS1 20.97685434 20.80827765 21.14543103 1.016202849 0.023188414 1 1 0.897010932 0.896291593 8651 suppressor of cytokine signaling 1 "GO:0001817,GO:0001932,GO:0004860,GO:0005159,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005942,GO:0006469,GO:0007259,GO:0010533,GO:0016567,GO:0019210,GO:0019221,GO:0019901,GO:0031410,GO:0035556,GO:0036464,GO:0038111,GO:0040008,GO:0042532,GO:0043372,GO:0043377,GO:0043551,GO:0045444,GO:0045591,GO:0046426,GO:0046627,GO:0046854,GO:0046935,GO:0060334,GO:0071230" "regulation of cytokine production|regulation of protein phosphorylation|protein kinase inhibitor activity|insulin-like growth factor receptor binding|protein binding|nucleoplasm|cytoplasm|cytosol|phosphatidylinositol 3-kinase complex|negative regulation of protein kinase activity|receptor signaling pathway via JAK-STAT|regulation of activation of Janus kinase activity|protein ubiquitination|kinase inhibitor activity|cytokine-mediated signaling pathway|protein kinase binding|cytoplasmic vesicle|intracellular signal transduction|cytoplasmic ribonucleoprotein granule|interleukin-7-mediated signaling pathway|regulation of growth|negative regulation of tyrosine phosphorylation of STAT protein|positive regulation of CD4-positive, alpha-beta T cell differentiation|negative regulation of CD8-positive, alpha-beta T cell differentiation|regulation of phosphatidylinositol 3-kinase activity|fat cell differentiation|positive regulation of regulatory T cell differentiation|negative regulation of receptor signaling pathway via JAK-STAT|negative regulation of insulin receptor signaling pathway|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity|regulation of interferon-gamma-mediated signaling pathway|cellular response to amino acid stimulus" "hsa04120,hsa04380,hsa04630,hsa04910,hsa04917,hsa04930,hsa04935,hsa05145,hsa05206" "Ubiquitin mediated proteolysis|Osteoclast differentiation|JAK-STAT signaling pathway|Insulin signaling pathway|Prolactin signaling pathway|Type II diabetes mellitus|Growth hormone synthesis, secretion and action|Toxoplasmosis|MicroRNAs in cancer" SOCS2 752.4562812 816.7248979 688.1876645 0.842618691 -0.247048176 0.330655887 1 7.262097088 6.016782574 8835 suppressor of cytokine signaling 2 "GO:0001558,GO:0005131,GO:0005159,GO:0005515,GO:0005737,GO:0005829,GO:0005942,GO:0007259,GO:0007595,GO:0008269,GO:0009966,GO:0016567,GO:0032355,GO:0032870,GO:0035556,GO:0038111,GO:0040015,GO:0043066,GO:0043551,GO:0043687,GO:0045666,GO:0046426,GO:0046854,GO:0046935,GO:0060396,GO:0060749" regulation of cell growth|growth hormone receptor binding|insulin-like growth factor receptor binding|protein binding|cytoplasm|cytosol|phosphatidylinositol 3-kinase complex|receptor signaling pathway via JAK-STAT|lactation|JAK pathway signal transduction adaptor activity|regulation of signal transduction|protein ubiquitination|response to estradiol|cellular response to hormone stimulus|intracellular signal transduction|interleukin-7-mediated signaling pathway|negative regulation of multicellular organism growth|negative regulation of apoptotic process|regulation of phosphatidylinositol 3-kinase activity|post-translational protein modification|positive regulation of neuron differentiation|negative regulation of receptor signaling pathway via JAK-STAT|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity|growth hormone receptor signaling pathway|mammary gland alveolus development "hsa04630,hsa04910,hsa04917,hsa04930,hsa04935" "JAK-STAT signaling pathway|Insulin signaling pathway|Prolactin signaling pathway|Type II diabetes mellitus|Growth hormone synthesis, secretion and action" SOCS3 667.1920326 622.1675018 712.2165634 1.144734435 0.195012948 0.451828131 1 11.74529044 13.22025056 9021 suppressor of cytokine signaling 3 "GO:0001784,GO:0004860,GO:0005515,GO:0005829,GO:0005942,GO:0006469,GO:0007259,GO:0016567,GO:0019221,GO:0035556,GO:0040008,GO:0042531,GO:0042532,GO:0043066,GO:0043551,GO:0043687,GO:0045597,GO:0046426,GO:0046627,GO:0046854,GO:0046935,GO:0050728,GO:0060334,GO:0060670,GO:0060674,GO:0060707,GO:0070102,GO:1990830" phosphotyrosine residue binding|protein kinase inhibitor activity|protein binding|cytosol|phosphatidylinositol 3-kinase complex|negative regulation of protein kinase activity|receptor signaling pathway via JAK-STAT|protein ubiquitination|cytokine-mediated signaling pathway|intracellular signal transduction|regulation of growth|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of tyrosine phosphorylation of STAT protein|negative regulation of apoptotic process|regulation of phosphatidylinositol 3-kinase activity|post-translational protein modification|positive regulation of cell differentiation|negative regulation of receptor signaling pathway via JAK-STAT|negative regulation of insulin receptor signaling pathway|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity|negative regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|branching involved in labyrinthine layer morphogenesis|placenta blood vessel development|trophoblast giant cell differentiation|interleukin-6-mediated signaling pathway|cellular response to leukemia inhibitory factor "hsa04120,hsa04380,hsa04630,hsa04668,hsa04910,hsa04917,hsa04920,hsa04930,hsa04931,hsa04932,hsa04935,hsa05160,hsa05164,hsa05168" "Ubiquitin mediated proteolysis|Osteoclast differentiation|JAK-STAT signaling pathway|TNF signaling pathway|Insulin signaling pathway|Prolactin signaling pathway|Adipocytokine signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|Growth hormone synthesis, secretion and action|Hepatitis C|Influenza A|Herpes simplex virus 1 infection" SOCS4 1359.194868 1391.033361 1327.356375 0.95422325 -0.067601256 0.780592553 1 10.50472532 9.856117537 122809 suppressor of cytokine signaling 4 "GO:0005515,GO:0005942,GO:0007175,GO:0016567,GO:0032436,GO:0035556,GO:0040008,GO:0043551,GO:0046854,GO:0046935" protein binding|phosphatidylinositol 3-kinase complex|negative regulation of epidermal growth factor-activated receptor activity|protein ubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|intracellular signal transduction|regulation of growth|regulation of phosphatidylinositol 3-kinase activity|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity "hsa04630,hsa04910,hsa04917,hsa04930" JAK-STAT signaling pathway|Insulin signaling pathway|Prolactin signaling pathway|Type II diabetes mellitus SOCS5 610.0724503 649.2182628 570.9266379 0.879406312 -0.185398208 0.481577449 1 7.012261783 6.063437114 9655 suppressor of cytokine signaling 5 "GO:0005154,GO:0005515,GO:0005829,GO:0005942,GO:0007173,GO:0007175,GO:0007259,GO:0009968,GO:0016567,GO:0019221,GO:0030971,GO:0032436,GO:0032715,GO:0035556,GO:0040008,GO:0043551,GO:0043687,GO:0045627,GO:0045629,GO:0046854,GO:0046935,GO:0050728,GO:0071404,GO:0071638,GO:0097699" epidermal growth factor receptor binding|protein binding|cytosol|phosphatidylinositol 3-kinase complex|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor-activated receptor activity|receptor signaling pathway via JAK-STAT|negative regulation of signal transduction|protein ubiquitination|cytokine-mediated signaling pathway|receptor tyrosine kinase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of interleukin-6 production|intracellular signal transduction|regulation of growth|regulation of phosphatidylinositol 3-kinase activity|post-translational protein modification|positive regulation of T-helper 1 cell differentiation|negative regulation of T-helper 2 cell differentiation|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity|negative regulation of inflammatory response|cellular response to low-density lipoprotein particle stimulus|negative regulation of monocyte chemotactic protein-1 production|vascular endothelial cell response to fluid shear stress "hsa04630,hsa04917" JAK-STAT signaling pathway|Prolactin signaling pathway SOCS6 863.344648 1027.928916 698.76038 0.679775001 -0.556870788 0.025609229 0.86539048 8.875372431 5.93229793 9306 suppressor of cytokine signaling 6 "GO:0001772,GO:0005515,GO:0005737,GO:0005829,GO:0005942,GO:0006952,GO:0007259,GO:0009968,GO:0010498,GO:0016567,GO:0035556,GO:0040008,GO:0043551,GO:0043687,GO:0046854,GO:0046935,GO:0050868" immunological synapse|protein binding|cytoplasm|cytosol|phosphatidylinositol 3-kinase complex|defense response|receptor signaling pathway via JAK-STAT|negative regulation of signal transduction|proteasomal protein catabolic process|protein ubiquitination|intracellular signal transduction|regulation of growth|regulation of phosphatidylinositol 3-kinase activity|post-translational protein modification|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity|negative regulation of T cell activation "hsa04630,hsa04917" JAK-STAT signaling pathway|Prolactin signaling pathway SOCS7 596.2596063 639.8545378 552.6646747 0.863734868 -0.211339564 0.423787256 1 4.13512481 3.511884731 30837 suppressor of cytokine signaling 7 "GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0005942,GO:0008150,GO:0009968,GO:0016567,GO:0017124,GO:0035556,GO:0040008,GO:0043551,GO:0046854,GO:0046935" protein binding|nucleus|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|biological_process|negative regulation of signal transduction|protein ubiquitination|SH3 domain binding|intracellular signal transduction|regulation of growth|regulation of phosphatidylinositol 3-kinase activity|phosphatidylinositol phosphorylation|1-phosphatidylinositol-3-kinase regulator activity "hsa04630,hsa04917" JAK-STAT signaling pathway|Prolactin signaling pathway SOD1 2550.479208 2057.93866 3043.019757 1.478673692 0.564303719 0.017186012 0.770503287 122.7133005 178.4165601 6647 superoxide dismutase 1 "GO:0000187,GO:0000303,GO:0001541,GO:0001819,GO:0001890,GO:0001895,GO:0001975,GO:0002262,GO:0002576,GO:0004784,GO:0005507,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005758,GO:0005759,GO:0005764,GO:0005777,GO:0005829,GO:0005886,GO:0006749,GO:0006801,GO:0006879,GO:0007283,GO:0007566,GO:0007569,GO:0007605,GO:0007626,GO:0008089,GO:0008090,GO:0008217,GO:0008270,GO:0009408,GO:0010033,GO:0019226,GO:0019430,GO:0030346,GO:0031045,GO:0031267,GO:0031410,GO:0031667,GO:0032287,GO:0032839,GO:0032930,GO:0032991,GO:0033081,GO:0034465,GO:0034599,GO:0035722,GO:0035865,GO:0040014,GO:0042493,GO:0042542,GO:0042554,GO:0042802,GO:0043025,GO:0043065,GO:0043085,GO:0043087,GO:0043524,GO:0045471,GO:0045541,GO:0045859,GO:0046620,GO:0046677,GO:0046688,GO:0046716,GO:0048538,GO:0048678,GO:0050665,GO:0050728,GO:0050766,GO:0051087,GO:0051881,GO:0055114,GO:0060047,GO:0060052,GO:0060087,GO:0060088,GO:0070062,GO:0071276,GO:0071318,GO:0072593,GO:0097332,GO:1902177,GO:1904115" activation of MAPK activity|response to superoxide|ovarian follicle development|positive regulation of cytokine production|placenta development|retina homeostasis|response to amphetamine|myeloid cell homeostasis|platelet degranulation|superoxide dismutase activity|copper ion binding|protein binding|extracellular region|extracellular space|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial intermembrane space|mitochondrial matrix|lysosome|peroxisome|cytosol|plasma membrane|glutathione metabolic process|superoxide metabolic process|cellular iron ion homeostasis|spermatogenesis|embryo implantation|cell aging|sensory perception of sound|locomotory behavior|anterograde axonal transport|retrograde axonal transport|regulation of blood pressure|zinc ion binding|response to heat|response to organic substance|transmission of nerve impulse|removal of superoxide radicals|protein phosphatase 2B binding|dense core granule|small GTPase binding|cytoplasmic vesicle|response to nutrient levels|peripheral nervous system myelin maintenance|dendrite cytoplasm|positive regulation of superoxide anion generation|protein-containing complex|regulation of T cell differentiation in thymus|response to carbon monoxide|cellular response to oxidative stress|interleukin-12-mediated signaling pathway|cellular response to potassium ion|regulation of multicellular organism growth|response to drug|response to hydrogen peroxide|superoxide anion generation|identical protein binding|neuronal cell body|positive regulation of apoptotic process|positive regulation of catalytic activity|regulation of GTPase activity|negative regulation of neuron apoptotic process|response to ethanol|negative regulation of cholesterol biosynthetic process|regulation of protein kinase activity|regulation of organ growth|response to antibiotic|response to copper ion|muscle cell cellular homeostasis|thymus development|response to axon injury|hydrogen peroxide biosynthetic process|negative regulation of inflammatory response|positive regulation of phagocytosis|chaperone binding|regulation of mitochondrial membrane potential|oxidation-reduction process|heart contraction|neurofilament cytoskeleton organization|relaxation of vascular associated smooth muscle|auditory receptor cell stereocilium organization|extracellular exosome|cellular response to cadmium ion|cellular response to ATP|reactive oxygen species metabolic process|response to antipsychotic drug|positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|axon cytoplasm "hsa04146,hsa04213,hsa05014,hsa05016,hsa05020,hsa05022" Peroxisome|Longevity regulating pathway - multiple species|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases SOD2 10477.29904 10490.49318 10464.10489 0.997484552 -0.003633596 0.988933468 1 31.82459869 31.2133436 6648 superoxide dismutase 2 "GO:0000303,GO:0001315,GO:0001666,GO:0001836,GO:0003069,GO:0003677,GO:0004784,GO:0005515,GO:0005739,GO:0005759,GO:0006357,GO:0006801,GO:0008217,GO:0008285,GO:0009314,GO:0009409,GO:0010042,GO:0010043,GO:0010269,GO:0010729,GO:0014823,GO:0019430,GO:0019825,GO:0019899,GO:0030145,GO:0030335,GO:0032364,GO:0032496,GO:0033591,GO:0034021,GO:0034599,GO:0035722,GO:0035900,GO:0035902,GO:0042493,GO:0042542,GO:0042645,GO:0042802,GO:0043524,GO:0046686,GO:0050665,GO:0051289,GO:0051602,GO:0055114,GO:0070062,GO:0071000,GO:0071361,GO:1902176,GO:1902631,GO:1904706,GO:1905461,GO:1905932" response to superoxide|age-dependent response to reactive oxygen species|response to hypoxia|release of cytochrome c from mitochondria|acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure|DNA binding|superoxide dismutase activity|protein binding|mitochondrion|mitochondrial matrix|regulation of transcription by RNA polymerase II|superoxide metabolic process|regulation of blood pressure|negative regulation of cell population proliferation|response to radiation|response to cold|response to manganese ion|response to zinc ion|response to selenium ion|positive regulation of hydrogen peroxide biosynthetic process|response to activity|removal of superoxide radicals|oxygen binding|enzyme binding|manganese ion binding|positive regulation of cell migration|oxygen homeostasis|response to lipopolysaccharide|response to L-ascorbic acid|response to silicon dioxide|cellular response to oxidative stress|interleukin-12-mediated signaling pathway|response to isolation stress|response to immobilization stress|response to drug|response to hydrogen peroxide|mitochondrial nucleoid|identical protein binding|negative regulation of neuron apoptotic process|response to cadmium ion|hydrogen peroxide biosynthetic process|protein homotetramerization|response to electrical stimulus|oxidation-reduction process|extracellular exosome|response to magnetism|cellular response to ethanol|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|negative regulation of membrane hyperpolarization|negative regulation of vascular associated smooth muscle cell proliferation|positive regulation of vascular associated smooth muscle cell apoptotic process|positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching "hsa04068,hsa04146,hsa04211,hsa04213,hsa05016" FoxO signaling pathway|Peroxisome|Longevity regulating pathway|Longevity regulating pathway - multiple species|Huntington disease SOGA1 689.1640271 757.4213066 620.9067476 0.819764036 -0.286719395 0.264565887 1 7.076712719 5.704158779 140710 "suppressor of glucose, autophagy associated 1" "GO:0003674,GO:0005615,GO:0008286,GO:0010506,GO:0045721,GO:0070062" molecular_function|extracellular space|insulin receptor signaling pathway|regulation of autophagy|negative regulation of gluconeogenesis|extracellular exosome SOGA3 269.6571227 266.345954 272.9682915 1.024863669 0.03543201 0.925607738 1 1.237433102 1.246978615 387104 SOGA family member 3 "GO:0005615,GO:0010506,GO:0016021" extracellular space|regulation of autophagy|integral component of membrane SON 5802.868608 5939.722856 5666.014361 0.953918979 -0.068061359 0.77876038 1 29.61159197 27.77438329 6651 SON DNA and RNA binding protein "GO:0000226,GO:0000281,GO:0003677,GO:0003723,GO:0005515,GO:0006397,GO:0008380,GO:0016607,GO:0043066,GO:0043484,GO:0048024,GO:0051726" "microtubule cytoskeleton organization|mitotic cytokinesis|DNA binding|RNA binding|protein binding|mRNA processing|RNA splicing|nuclear speck|negative regulation of apoptotic process|regulation of RNA splicing|regulation of mRNA splicing, via spliceosome|regulation of cell cycle" SORBS1 820.0976604 1015.443949 624.7513714 0.615249489 -0.70075654 0.005294697 0.441493785 5.635060547 3.408953108 10580 sorbin and SH3 domain containing 1 "GO:0001725,GO:0003779,GO:0005158,GO:0005515,GO:0005634,GO:0005813,GO:0005829,GO:0005886,GO:0005912,GO:0005915,GO:0005925,GO:0006936,GO:0007160,GO:0008092,GO:0008286,GO:0016363,GO:0030055,GO:0030159,GO:0032869,GO:0043149,GO:0045121,GO:0045725,GO:0046326,GO:0046628,GO:0046889,GO:0048041,GO:1903078" stress fiber|actin binding|insulin receptor binding|protein binding|nucleus|centrosome|cytosol|plasma membrane|adherens junction|zonula adherens|focal adhesion|muscle contraction|cell-matrix adhesion|cytoskeletal protein binding|insulin receptor signaling pathway|nuclear matrix|cell-substrate junction|signaling receptor complex adaptor activity|cellular response to insulin stimulus|stress fiber assembly|membrane raft|positive regulation of glycogen biosynthetic process|positive regulation of glucose import|positive regulation of insulin receptor signaling pathway|positive regulation of lipid biosynthetic process|focal adhesion assembly|positive regulation of protein localization to plasma membrane "hsa03320,hsa04520,hsa04910" PPAR signaling pathway|Adherens junction|Insulin signaling pathway SORBS3 1248.905966 1182.950585 1314.861348 1.111509952 0.152520866 0.528787531 1 16.27110787 17.78286201 10174 sorbin and SH3 domain containing 3 "GO:0000122,GO:0005200,GO:0005515,GO:0005634,GO:0005829,GO:0005856,GO:0005925,GO:0006936,GO:0007015,GO:0007155,GO:0008134,GO:0017166,GO:0031589,GO:0043410,GO:0051495,GO:0051496" negative regulation of transcription by RNA polymerase II|structural constituent of cytoskeleton|protein binding|nucleus|cytosol|cytoskeleton|focal adhesion|muscle contraction|actin filament organization|cell adhesion|transcription factor binding|vinculin binding|cell-substrate adhesion|positive regulation of MAPK cascade|positive regulation of cytoskeleton organization|positive regulation of stress fiber assembly SORCS1 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.00752779 0.020513872 114815 sortilin related VPS10 domain containing receptor 1 "GO:0005515,GO:0005794,GO:0006892,GO:0007218,GO:0008188,GO:0016020,GO:0016021" protein binding|Golgi apparatus|post-Golgi vesicle-mediated transport|neuropeptide signaling pathway|neuropeptide receptor activity|membrane|integral component of membrane SORCS2 7.723846193 13.52538047 1.922311912 0.142126273 -2.814754828 0.050094394 1 0.136347695 0.019054315 57537 sortilin related VPS10 domain containing receptor 2 "GO:0005887,GO:0006886,GO:0007218,GO:0008188,GO:0016020,GO:0016021,GO:0030659,GO:0031901,GO:0043197,GO:0043204,GO:0055038,GO:0060292,GO:0098839" integral component of plasma membrane|intracellular protein transport|neuropeptide signaling pathway|neuropeptide receptor activity|membrane|integral component of membrane|cytoplasmic vesicle membrane|early endosome membrane|dendritic spine|perikaryon|recycling endosome membrane|long-term synaptic depression|postsynaptic density membrane SORD 569.8032798 601.3592242 538.2473354 0.895051267 -0.159957775 0.550071404 1 6.661153288 5.86230646 6652 sorbitol dehydrogenase "GO:0000721,GO:0003939,GO:0005615,GO:0005829,GO:0006006,GO:0006062,GO:0006970,GO:0008270,GO:0009725,GO:0016020,GO:0019640,GO:0030246,GO:0030317,GO:0031514,GO:0031667,GO:0031966,GO:0042493,GO:0042802,GO:0046370,GO:0046526,GO:0046686,GO:0046688,GO:0050255,GO:0051160,GO:0051164,GO:0051287,GO:0055114,GO:0070062" "(R,R)-butanediol dehydrogenase activity|L-iditol 2-dehydrogenase activity|extracellular space|cytosol|glucose metabolic process|sorbitol catabolic process|response to osmotic stress|zinc ion binding|response to hormone|membrane|glucuronate catabolic process to xylulose 5-phosphate|carbohydrate binding|flagellated sperm motility|motile cilium|response to nutrient levels|mitochondrial membrane|response to drug|identical protein binding|fructose biosynthetic process|D-xylulose reductase activity|response to cadmium ion|response to copper ion|ribitol 2-dehydrogenase activity|L-xylitol catabolic process|L-xylitol metabolic process|NAD binding|oxidation-reduction process|extracellular exosome" "hsa00040,hsa00051" Pentose and glucuronate interconversions|Fructose and mannose metabolism SORL1 191.5065803 208.0827765 174.930384 0.840676902 -0.250376659 0.503562536 1 1.022277027 0.845023711 6653 sortilin related receptor 1 "GO:0000139,GO:0001540,GO:0002024,GO:0004888,GO:0005041,GO:0005515,GO:0005615,GO:0005641,GO:0005768,GO:0005769,GO:0005771,GO:0005783,GO:0005789,GO:0005794,GO:0005802,GO:0005886,GO:0005887,GO:0006605,GO:0006622,GO:0006892,GO:0006898,GO:0007218,GO:0009986,GO:0010008,GO:0010897,GO:0014910,GO:0016020,GO:0016021,GO:0030169,GO:0030514,GO:0030658,GO:0031267,GO:0031333,GO:0031901,GO:0031985,GO:0032091,GO:0032585,GO:0034067,GO:0038020,GO:0042923,GO:0043407,GO:0044267,GO:0045053,GO:0045732,GO:0046628,GO:0050768,GO:0051604,GO:0055037,GO:0055038,GO:0070062,GO:0070863,GO:0097356,GO:1900168,GO:1901215,GO:1902430,GO:1902771,GO:1902948,GO:1902953,GO:1902955,GO:1902960,GO:1902963,GO:1902966,GO:1902997,GO:1904179,GO:1990845,GO:2001137" Golgi membrane|amyloid-beta binding|diet induced thermogenesis|transmembrane signaling receptor activity|low-density lipoprotein particle receptor activity|protein binding|extracellular space|nuclear envelope lumen|endosome|early endosome|multivesicular body|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|plasma membrane|integral component of plasma membrane|protein targeting|protein targeting to lysosome|post-Golgi vesicle-mediated transport|receptor-mediated endocytosis|neuropeptide signaling pathway|cell surface|endosome membrane|negative regulation of triglyceride catabolic process|regulation of smooth muscle cell migration|membrane|integral component of membrane|low-density lipoprotein particle binding|negative regulation of BMP signaling pathway|transport vesicle membrane|small GTPase binding|negative regulation of protein-containing complex assembly|early endosome membrane|Golgi cisterna|negative regulation of protein binding|multivesicular body membrane|protein localization to Golgi apparatus|insulin receptor recycling|neuropeptide binding|negative regulation of MAP kinase activity|cellular protein metabolic process|protein retention in Golgi apparatus|positive regulation of protein catabolic process|positive regulation of insulin receptor signaling pathway|negative regulation of neurogenesis|protein maturation|recycling endosome|recycling endosome membrane|extracellular exosome|positive regulation of protein exit from endoplasmic reticulum|perinucleolar compartment|positive regulation of glial cell-derived neurotrophic factor production|negative regulation of neuron death|negative regulation of amyloid-beta formation|positive regulation of choline O-acetyltransferase activity|negative regulation of tau-protein kinase activity|positive regulation of ER to Golgi vesicle-mediated transport|positive regulation of early endosome to recycling endosome transport|negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of protein localization to early endosome|negative regulation of neurofibrillary tangle assembly|positive regulation of adipose tissue development|adaptive thermogenesis|positive regulation of endocytic recycling SORT1 1443.891678 1204.799276 1682.984079 1.396899975 0.482228721 0.043859775 1 8.052338514 11.06008621 6272 sortilin 1 "GO:0001503,GO:0005515,GO:0005764,GO:0005765,GO:0005769,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0005905,GO:0006622,GO:0006892,GO:0006895,GO:0006897,GO:0007186,GO:0007218,GO:0007275,GO:0008333,GO:0008625,GO:0009986,GO:0010008,GO:0010465,GO:0010468,GO:0014902,GO:0016021,GO:0016050,GO:0019899,GO:0030136,GO:0030140,GO:0030379,GO:0030425,GO:0030659,GO:0031410,GO:0031965,GO:0032509,GO:0032580,GO:0032868,GO:0038180,GO:0043025,GO:0045599,GO:0046323,GO:0048011,GO:0048227,GO:0048406,GO:0048471,GO:0051005,GO:0090160,GO:1904037,GO:1905394" "ossification|protein binding|lysosome|lysosomal membrane|early endosome|endoplasmic reticulum membrane|Golgi apparatus|cytosol|plasma membrane|clathrin-coated pit|protein targeting to lysosome|post-Golgi vesicle-mediated transport|Golgi to endosome transport|endocytosis|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|multicellular organism development|endosome to lysosome transport|extrinsic apoptotic signaling pathway via death domain receptors|cell surface|endosome membrane|nerve growth factor receptor activity|regulation of gene expression|myotube differentiation|integral component of membrane|vesicle organization|enzyme binding|clathrin-coated vesicle|trans-Golgi network transport vesicle|neurotensin receptor activity, non-G protein-coupled|dendrite|cytoplasmic vesicle membrane|cytoplasmic vesicle|nuclear membrane|endosome transport via multivesicular body sorting pathway|Golgi cisterna membrane|response to insulin|nerve growth factor signaling pathway|neuronal cell body|negative regulation of fat cell differentiation|glucose import|neurotrophin TRK receptor signaling pathway|plasma membrane to endosome transport|nerve growth factor binding|perinuclear region of cytoplasm|negative regulation of lipoprotein lipase activity|Golgi to lysosome transport|positive regulation of epithelial cell apoptotic process|retromer complex binding" "hsa04142,hsa04722,hsa04979" Lysosome|Neurotrophin signaling pathway|Cholesterol metabolism SOS1 1261.325537 1370.225083 1152.425991 0.841048675 -0.249738797 0.300702557 1 7.994576838 6.611314099 6654 SOS Ras/Rac guanine nucleotide exchange factor 1 "GO:0000165,GO:0001782,GO:0001942,GO:0003209,GO:0003344,GO:0003677,GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0007173,GO:0007186,GO:0007265,GO:0007296,GO:0007411,GO:0008286,GO:0014069,GO:0017124,GO:0019221,GO:0033081,GO:0035264,GO:0038095,GO:0038128,GO:0042129,GO:0043025,GO:0043065,GO:0043547,GO:0045742,GO:0046982,GO:0048011,GO:0048514,GO:0050900,GO:0051056,GO:0051057,GO:0060021,GO:0061029,GO:0061384,GO:1904693,GO:2000973" MAPK cascade|B cell homeostasis|hair follicle development|cardiac atrium morphogenesis|pericardium morphogenesis|DNA binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytoplasm|cytosol|plasma membrane|signal transduction|epidermal growth factor receptor signaling pathway|G protein-coupled receptor signaling pathway|Ras protein signal transduction|vitellogenesis|axon guidance|insulin receptor signaling pathway|postsynaptic density|SH3 domain binding|cytokine-mediated signaling pathway|regulation of T cell differentiation in thymus|multicellular organism growth|Fc-epsilon receptor signaling pathway|ERBB2 signaling pathway|regulation of T cell proliferation|neuronal cell body|positive regulation of apoptotic process|positive regulation of GTPase activity|positive regulation of epidermal growth factor receptor signaling pathway|protein heterodimerization activity|neurotrophin TRK receptor signaling pathway|blood vessel morphogenesis|leukocyte migration|regulation of small GTPase mediated signal transduction|positive regulation of small GTPase mediated signal transduction|roof of mouth development|eyelid development in camera-type eye|heart trabecula morphogenesis|midbrain morphogenesis|regulation of pro-B cell differentiation "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04062,hsa04068,hsa04072,hsa04150,hsa04151,hsa04510,hsa04540,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04714,hsa04722,hsa04810,hsa04910,hsa04912,hsa04915,hsa04917,hsa04926,hsa04935,hsa05034,hsa05160,hsa05161,hsa05163,hsa05165,hsa05200,hsa05205,hsa05206,hsa05210,hsa05211,hsa05213,hsa05214,hsa05215,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05231" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Thermogenesis|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Alcoholism|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Endometrial cancer|Glioma|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Choline metabolism in cancer" SOS2 1065.747235 1030.009744 1101.484726 1.06939253 0.096791504 0.694746929 1 9.979979475 10.4939254 6655 SOS Ras/Rho guanine nucleotide exchange factor 2 "GO:0001782,GO:0003677,GO:0005085,GO:0005515,GO:0005829,GO:0007186,GO:0007264,GO:0033081,GO:0042129,GO:0043065,GO:0046982,GO:0050790,GO:0051056,GO:0051057,GO:2000973" B cell homeostasis|DNA binding|guanyl-nucleotide exchange factor activity|protein binding|cytosol|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|regulation of T cell differentiation in thymus|regulation of T cell proliferation|positive regulation of apoptotic process|protein heterodimerization activity|regulation of catalytic activity|regulation of small GTPase mediated signal transduction|positive regulation of small GTPase mediated signal transduction|regulation of pro-B cell differentiation "hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04062,hsa04068,hsa04072,hsa04150,hsa04151,hsa04510,hsa04540,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04714,hsa04722,hsa04810,hsa04910,hsa04912,hsa04915,hsa04917,hsa04926,hsa04935,hsa05034,hsa05160,hsa05161,hsa05163,hsa05165,hsa05200,hsa05205,hsa05206,hsa05210,hsa05211,hsa05213,hsa05214,hsa05215,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05231" "EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|JAK-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Thermogenesis|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Alcoholism|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Endometrial cancer|Glioma|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Choline metabolism in cancer" SOWAHA 12.8516881 9.363724944 16.33965125 1.744994791 0.80322273 0.460499144 1 0.143393053 0.246033036 134548 sosondowah ankyrin repeat domain family member A SOWAHB 6.524916457 7.282897178 5.766935736 0.791846376 -0.336707531 0.922510643 1 0.097339053 0.075787787 345079 sosondowah ankyrin repeat domain family member B GO:0005515 protein binding SOWAHC 634.1856376 638.8141239 629.5571512 0.985509129 -0.021058859 0.942015754 1 7.36812961 7.139849988 65124 sosondowah ankyrin repeat domain family member C SOWAHD 5.965080553 5.202069413 6.728091692 1.29334908 0.371111717 0.919461532 1 0.171903953 0.218611397 347454 sosondowah ankyrin repeat domain family member D SOX12 955.5067938 999.8377412 911.1758463 0.911323717 -0.133964482 0.589456343 1 11.41868235 10.23198378 6666 SRY-box transcription factor 12 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0005654,GO:0006355,GO:0009653,GO:0021510,GO:0030154,GO:0032993,GO:0045165,GO:0045591,GO:0045944,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|nucleoplasm|regulation of transcription, DNA-templated|anatomical structure morphogenesis|spinal cord development|cell differentiation|protein-DNA complex|cell fate commitment|positive regulation of regulatory T cell differentiation|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" SOX13 636.370261 683.5519209 589.188601 0.861951496 -0.214321407 0.411526574 1 8.908402858 7.550120014 9580 SRY-box transcription factor 13 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001217,GO:0001227,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006357,GO:0009653,GO:0021529,GO:0042492,GO:0042802,GO:0043565,GO:0045165,GO:0045588,GO:0045892,GO:0090090,GO:0090336" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|spinal cord oligodendrocyte cell differentiation|gamma-delta T cell differentiation|identical protein binding|sequence-specific DNA binding|cell fate commitment|positive regulation of gamma-delta T cell differentiation|negative regulation of transcription, DNA-templated|negative regulation of canonical Wnt signaling pathway|positive regulation of brown fat cell differentiation" SOX15 4.523346619 5.202069413 3.844623824 0.739056617 -0.436243205 0.933440272 1 0.210321882 0.152838704 6665 SRY-box transcription factor 15 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005667,GO:0005737,GO:0006325,GO:0006355,GO:0006357,GO:0008584,GO:0009653,GO:0014718,GO:0030154,GO:0043403,GO:0045843,GO:0045944,GO:0048627,GO:0060707,GO:0070318,GO:2000288" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|transcription regulator complex|cytoplasm|chromatin organization|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|male gonad development|anatomical structure morphogenesis|positive regulation of satellite cell activation involved in skeletal muscle regeneration|cell differentiation|skeletal muscle tissue regeneration|negative regulation of striated muscle tissue development|positive regulation of transcription by RNA polymerase II|myoblast development|trophoblast giant cell differentiation|positive regulation of G0 to G1 transition|positive regulation of myoblast proliferation" SOX18 15.49235177 15.60620824 15.3784953 0.985408823 -0.021205706 1 1 0.447301101 0.433398688 54345 SRY-box transcription factor 18 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001525,GO:0001570,GO:0001701,GO:0001942,GO:0001944,GO:0001946,GO:0001947,GO:0003151,GO:0005634,GO:0005667,GO:0006355,GO:0009653,GO:0022405,GO:0030154,GO:0035050,GO:0043534,GO:0045892,GO:0045893,GO:0045944,GO:0048469,GO:0048866,GO:0060214,GO:0060836,GO:0060956,GO:0061028,GO:0072091,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|vasculogenesis|in utero embryonic development|hair follicle development|vasculature development|lymphangiogenesis|heart looping|outflow tract morphogenesis|nucleus|transcription regulator complex|regulation of transcription, DNA-templated|anatomical structure morphogenesis|hair cycle process|cell differentiation|embryonic heart tube development|blood vessel endothelial cell migration|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cell maturation|stem cell fate specification|endocardium formation|lymphatic endothelial cell differentiation|endocardial cell differentiation|establishment of endothelial barrier|regulation of stem cell proliferation|sequence-specific double-stranded DNA binding" SOX21 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.05696817 0.051747714 11166 SRY-box transcription factor 21 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001942,GO:0003677,GO:0003700,GO:0005575,GO:0005634,GO:0006355,GO:0006357,GO:0009653,GO:0030154,GO:0045944,GO:0048863" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|hair follicle development|DNA binding|DNA-binding transcription factor activity|cellular_component|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|cell differentiation|positive regulation of transcription by RNA polymerase II|stem cell differentiation" SOX4 376.6517903 400.5593448 352.7442358 0.880629151 -0.183393493 0.53684347 1 4.390453078 3.801662653 6659 SRY-box transcription factor 4 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001501,GO:0001841,GO:0002328,GO:0003183,GO:0003211,GO:0003215,GO:0003289,GO:0003357,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005739,GO:0006355,GO:0006977,GO:0007507,GO:0008284,GO:0008285,GO:0009653,GO:0014009,GO:0021510,GO:0021522,GO:0021782,GO:0030154,GO:0030217,GO:0031018,GO:0031397,GO:0031647,GO:0032024,GO:0035019,GO:0035198,GO:0035910,GO:0042593,GO:0042769,GO:0043065,GO:0045588,GO:0045727,GO:0045893,GO:0045944,GO:0048485,GO:0050821,GO:0060174,GO:0060412,GO:0060548,GO:0060563,GO:0060993,GO:0061484,GO:0071333,GO:0090263,GO:1990837,GO:2000761" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|skeletal system development|neural tube formation|pro-B cell differentiation|mitral valve morphogenesis|cardiac ventricle formation|cardiac right ventricle morphogenesis|atrial septum primum morphogenesis|noradrenergic neuron differentiation|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|mitochondrion|regulation of transcription, DNA-templated|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|heart development|positive regulation of cell population proliferation|negative regulation of cell population proliferation|anatomical structure morphogenesis|glial cell proliferation|spinal cord development|spinal cord motor neuron differentiation|glial cell development|cell differentiation|T cell differentiation|endocrine pancreas development|negative regulation of protein ubiquitination|regulation of protein stability|positive regulation of insulin secretion|somatic stem cell population maintenance|miRNA binding|ascending aorta morphogenesis|glucose homeostasis|DNA damage response, detection of DNA damage|positive regulation of apoptotic process|positive regulation of gamma-delta T cell differentiation|positive regulation of translation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|sympathetic nervous system development|protein stabilization|limb bud formation|ventricular septum morphogenesis|negative regulation of cell death|neuroepithelial cell differentiation|kidney morphogenesis|hematopoietic stem cell homeostasis|cellular response to glucose stimulus|positive regulation of canonical Wnt signaling pathway|sequence-specific double-stranded DNA binding|positive regulation of N-terminal peptidyl-lysine acetylation" hsa05206 MicroRNAs in cancer HMG SOX5 71.9376273 71.7885579 72.0866967 1.004153013 0.005979124 1 1 0.235001128 0.232028334 6660 SRY-box transcription factor 5 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001502,GO:0002062,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0006366,GO:0032332,GO:0045165,GO:0051216,GO:0055059,GO:0061036,GO:0071560,GO:2000741" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cartilage condensation|chondrocyte differentiation|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|positive regulation of chondrocyte differentiation|cell fate commitment|cartilage development|asymmetric neuroblast division|positive regulation of cartilage development|cellular response to transforming growth factor beta stimulus|positive regulation of mesenchymal stem cell differentiation" SOX6 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.01499161 55553 SRY-box transcription factor 6 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001217,GO:0001502,GO:0002062,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0007417,GO:0007517,GO:0021529,GO:0032332,GO:0045165,GO:0045892,GO:0048708,GO:0051216,GO:0061036,GO:0071560,GO:2000726,GO:2000741" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity|cartilage condensation|chondrocyte differentiation|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|central nervous system development|muscle organ development|spinal cord oligodendrocyte cell differentiation|positive regulation of chondrocyte differentiation|cell fate commitment|negative regulation of transcription, DNA-templated|astrocyte differentiation|cartilage development|positive regulation of cartilage development|cellular response to transforming growth factor beta stimulus|negative regulation of cardiac muscle cell differentiation|positive regulation of mesenchymal stem cell differentiation" SOX7 734.4031381 696.0368875 772.7693886 1.110242004 0.150874181 0.55574907 1 11.55403092 12.61311508 83595 SRY-box transcription factor 7 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001706,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006357,GO:0008285,GO:0009653,GO:0030154,GO:0043280,GO:0045892,GO:0045893,GO:0060828,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|endoderm formation|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|negative regulation of cell population proliferation|anatomical structure morphogenesis|cell differentiation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|regulation of canonical Wnt signaling pathway|sequence-specific double-stranded DNA binding" SOX9 948.3975037 951.9787026 944.8163047 0.992476305 -0.010895437 0.969552234 1 12.92428229 12.61240072 6662 SRY-box transcription factor 9 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0000987,GO:0001228,GO:0001501,GO:0001502,GO:0001503,GO:0001658,GO:0001708,GO:0001837,GO:0001894,GO:0001934,GO:0001942,GO:0002009,GO:0002053,GO:0002062,GO:0002683,GO:0003170,GO:0003179,GO:0003180,GO:0003188,GO:0003203,GO:0003413,GO:0003415,GO:0003430,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006334,GO:0006338,GO:0006357,GO:0006367,GO:0007010,GO:0007165,GO:0007173,GO:0007219,GO:0007283,GO:0007507,GO:0008013,GO:0008284,GO:0008584,GO:0010564,GO:0010628,GO:0010634,GO:0014032,GO:0014036,GO:0014068,GO:0019100,GO:0019933,GO:0030155,GO:0030198,GO:0030279,GO:0030502,GO:0030850,GO:0030857,GO:0030858,GO:0030879,GO:0030903,GO:0030916,GO:0031018,GO:0032331,GO:0032332,GO:0032808,GO:0032991,GO:0034236,GO:0034504,GO:0035019,GO:0035622,GO:0042127,GO:0042981,GO:0043066,GO:0043425,GO:0043491,GO:0043565,GO:0045662,GO:0045668,GO:0045732,GO:0045892,GO:0045893,GO:0045944,GO:0046322,GO:0046533,GO:0048709,GO:0050679,GO:0050680,GO:0051216,GO:0060008,GO:0060009,GO:0060018,GO:0060041,GO:0060174,GO:0060221,GO:0060441,GO:0060487,GO:0060517,GO:0060532,GO:0060534,GO:0060729,GO:0060784,GO:0061036,GO:0061046,GO:0061138,GO:0061145,GO:0065003,GO:0070168,GO:0070371,GO:0070384,GO:0070542,GO:0071260,GO:0071300,GO:0071347,GO:0071364,GO:0071504,GO:0071560,GO:0071773,GO:0072034,GO:0072190,GO:0072193,GO:0072197,GO:0072289,GO:0090090,GO:0090103,GO:0090184,GO:0090190,GO:0097065,GO:0097157,GO:0098609,GO:1901203,GO:1902732,GO:1902894,GO:1904864,GO:1990837,GO:2000020,GO:2000138,GO:2000741,GO:2000794,GO:2001054" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|skeletal system development|cartilage condensation|ossification|branching involved in ureteric bud morphogenesis|cell fate specification|epithelial to mesenchymal transition|tissue homeostasis|positive regulation of protein phosphorylation|hair follicle development|morphogenesis of an epithelium|positive regulation of mesenchymal cell proliferation|chondrocyte differentiation|negative regulation of immune system process|heart valve development|heart valve morphogenesis|aortic valve morphogenesis|heart valve formation|endocardial cushion morphogenesis|chondrocyte differentiation involved in endochondral bone morphogenesis|chondrocyte hypertrophy|growth plate cartilage chondrocyte growth|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleosome assembly|chromatin remodeling|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|cytoskeleton organization|signal transduction|epidermal growth factor receptor signaling pathway|Notch signaling pathway|spermatogenesis|heart development|beta-catenin binding|positive regulation of cell population proliferation|male gonad development|regulation of cell cycle process|positive regulation of gene expression|positive regulation of epithelial cell migration|neural crest cell development|neural crest cell fate specification|positive regulation of phosphatidylinositol 3-kinase signaling|male germ-line sex determination|cAMP-mediated signaling|regulation of cell adhesion|extracellular matrix organization|negative regulation of ossification|negative regulation of bone mineralization|prostate gland development|negative regulation of epithelial cell differentiation|positive regulation of epithelial cell differentiation|mammary gland development|notochord development|otic vesicle formation|endocrine pancreas development|negative regulation of chondrocyte differentiation|positive regulation of chondrocyte differentiation|lacrimal gland development|protein-containing complex|protein kinase A catalytic subunit binding|protein localization to nucleus|somatic stem cell population maintenance|intrahepatic bile duct development|regulation of cell population proliferation|regulation of apoptotic process|negative regulation of apoptotic process|bHLH transcription factor binding|protein kinase B signaling|sequence-specific DNA binding|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|positive regulation of protein catabolic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of fatty acid oxidation|negative regulation of photoreceptor cell differentiation|oligodendrocyte differentiation|positive regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|cartilage development|Sertoli cell differentiation|Sertoli cell development|astrocyte fate commitment|retina development in camera-type eye|limb bud formation|retinal rod cell differentiation|epithelial tube branching involved in lung morphogenesis|lung epithelial cell differentiation|epithelial cell proliferation involved in prostatic bud elongation|bronchus cartilage development|trachea cartilage development|intestinal epithelial structure maintenance|regulation of cell proliferation involved in tissue homeostasis|positive regulation of cartilage development|regulation of branching involved in lung morphogenesis|morphogenesis of a branching epithelium|lung smooth muscle development|protein-containing complex assembly|negative regulation of biomineral tissue development|ERK1 and ERK2 cascade|Harderian gland development|response to fatty acid|cellular response to mechanical stimulus|cellular response to retinoic acid|cellular response to interleukin-1|cellular response to epidermal growth factor stimulus|cellular response to heparin|cellular response to transforming growth factor beta stimulus|cellular response to BMP stimulus|renal vesicle induction|ureter urothelium development|ureter smooth muscle cell differentiation|ureter morphogenesis|metanephric nephron tubule formation|negative regulation of canonical Wnt signaling pathway|cochlea morphogenesis|positive regulation of kidney development|positive regulation of branching involved in ureteric bud morphogenesis|anterior head development|pre-mRNA intronic binding|cell-cell adhesion|positive regulation of extracellular matrix assembly|positive regulation of chondrocyte proliferation|negative regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of beta-catenin-TCF complex assembly|sequence-specific double-stranded DNA binding|positive regulation of male gonad development|positive regulation of cell proliferation involved in heart morphogenesis|positive regulation of mesenchymal stem cell differentiation|regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell apoptotic process" hsa04024 cAMP signaling pathway HMG SP1 3714.309125 3871.380057 3557.238193 0.918855328 -0.122090365 0.607910834 1 26.75928485 24.17646607 6667 Sp1 transcription factor "GO:0000785,GO:0000791,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0000987,GO:0001103,GO:0001228,GO:0003677,GO:0003690,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006357,GO:0008022,GO:0008134,GO:0010628,GO:0016032,GO:0017053,GO:0032869,GO:0032993,GO:0033194,GO:0035035,GO:0042795,GO:0042803,GO:0042826,GO:0043425,GO:0043536,GO:0043565,GO:0043923,GO:0045540,GO:0045766,GO:0045893,GO:0045944,GO:0046872,GO:0048511,GO:0070491,GO:0071837,GO:1902004,GO:1904828,GO:1905564,GO:1990837" "chromatin|euchromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|RNA polymerase II repressing transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|double-stranded DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|protein C-terminus binding|transcription factor binding|positive regulation of gene expression|viral process|transcription repressor complex|cellular response to insulin stimulus|protein-DNA complex|response to hydroperoxide|histone acetyltransferase binding|snRNA transcription by RNA polymerase II|protein homodimerization activity|histone deacetylase binding|bHLH transcription factor binding|positive regulation of blood vessel endothelial cell migration|sequence-specific DNA binding|positive regulation by host of viral transcription|regulation of cholesterol biosynthetic process|positive regulation of angiogenesis|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|rhythmic process|repressing transcription factor binding|HMG box domain binding|positive regulation of amyloid-beta formation|positive regulation of hydrogen sulfide biosynthetic process|positive regulation of vascular endothelial cell proliferation|sequence-specific double-stranded DNA binding" "hsa01522,hsa04137,hsa04350,hsa04915,hsa04927,hsa04928,hsa04934,hsa05016,hsa05017,hsa05163,hsa05200,hsa05202,hsa05224,hsa05231" "Endocrine resistance|Mitophagy - animal|TGF-beta signaling pathway|Estrogen signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Huntington disease|Spinocerebellar ataxia|Human cytomegalovirus infection|Pathways in cancer|Transcriptional misregulation in cancer|Breast cancer|Choline metabolism in cancer" zf-C2H2 SP100 2105.642638 2012.160449 2199.124827 1.092917232 0.128184147 0.588688135 1 14.12592804 15.18012828 6672 SP100 nuclear antigen "GO:0000122,GO:0000723,GO:0000781,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006978,GO:0010596,GO:0016032,GO:0016604,GO:0016605,GO:0019900,GO:0019904,GO:0030870,GO:0034340,GO:0034341,GO:0042802,GO:0043392,GO:0043433,GO:0045185,GO:0045765,GO:0045893,GO:0046826,GO:0046983,GO:0051271,GO:0060333,GO:0060337,GO:0070087,GO:1902041,GO:1902044" "negative regulation of transcription by RNA polymerase II|telomere maintenance|chromosome, telomeric region|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of endothelial cell migration|viral process|nuclear body|PML body|kinase binding|protein domain specific binding|Mre11 complex|response to type I interferon|response to interferon-gamma|identical protein binding|negative regulation of DNA binding|negative regulation of DNA-binding transcription factor activity|maintenance of protein location|regulation of angiogenesis|positive regulation of transcription, DNA-templated|negative regulation of protein export from nucleus|protein dimerization activity|negative regulation of cellular component movement|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|chromo shadow domain binding|regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of Fas signaling pathway" "hsa05168,hsa05203" Herpes simplex virus 1 infection|Viral carcinogenesis SP110 345.2016001 331.8920286 358.5111716 1.080204225 0.111304097 0.719227103 1 2.54672431 2.704948396 3431 SP110 nuclear body protein "GO:0000981,GO:0003677,GO:0005634,GO:0005654,GO:0006357,GO:0016032,GO:0046872" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|viral process|metal ion binding" SP140 53.83921041 63.46524684 44.21317398 0.69665173 -0.521490491 0.377967585 1 0.463341119 0.317385982 11262 SP140 nuclear body protein "GO:0000981,GO:0001650,GO:0003677,GO:0005515,GO:0005634,GO:0005739,GO:0006357,GO:0006952,GO:0016605,GO:0046872" "DNA-binding transcription factor activity, RNA polymerase II-specific|fibrillar center|DNA binding|protein binding|nucleus|mitochondrion|regulation of transcription by RNA polymerase II|defense response|PML body|metal ion binding" SP140L 439.1068058 450.4992112 427.7144004 0.949423195 -0.074876799 0.7976226 1 4.104885593 3.832057999 93349 SP140 nuclear body protein like "GO:0000981,GO:0003677,GO:0005634,GO:0006357,GO:0016604,GO:0046872" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription by RNA polymerase II|nuclear body|metal ion binding" SP2 338.9886849 345.417409 332.5599608 0.962777069 -0.054726314 0.866120787 1 2.273312649 2.152068472 6668 Sp2 transcription factor "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005654,GO:0006357,GO:0006955,GO:0035264,GO:0042826,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|immune response|multicellular organism growth|histone deacetylase binding|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 SP3 2315.672879 2365.901169 2265.444588 0.957539824 -0.062595606 0.792578581 1 10.49225503 9.878633244 6670 Sp3 transcription factor "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0000987,GO:0001227,GO:0001503,GO:0001779,GO:0001829,GO:0001889,GO:0001892,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0016605,GO:0017053,GO:0030183,GO:0030217,GO:0030219,GO:0030224,GO:0030324,GO:0030851,GO:0032993,GO:0043353,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0048596,GO:0048706,GO:0060136,GO:0060216,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|ossification|natural killer cell differentiation|trophectodermal cell differentiation|liver development|embryonic placenta development|chromatin binding|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|PML body|transcription repressor complex|B cell differentiation|T cell differentiation|megakaryocyte differentiation|monocyte differentiation|lung development|granulocyte differentiation|protein-DNA complex|enucleate erythrocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|embryonic camera-type eye morphogenesis|embryonic skeletal system development|embryonic process involved in female pregnancy|definitive hemopoiesis|sequence-specific double-stranded DNA binding" zf-C2H2 SP4 330.0212496 337.094098 322.9484012 0.958036356 -0.06184769 0.848913416 1 1.546204766 1.456532489 6671 Sp4 transcription factor "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0042802,GO:0043565,GO:0046872" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|identical protein binding|sequence-specific DNA binding|metal ion binding" zf-C2H2 SP5 44.67363028 49.93986637 39.4073942 0.789096909 -0.341725606 0.603422348 1 0.842351101 0.653573852 389058 Sp5 transcription factor "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0036342,GO:0046872,GO:0060349,GO:0071407" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|post-anal tail morphogenesis|metal ion binding|bone morphogenesis|cellular response to organic cyclic compound" SP6 55.8061817 52.02069413 59.59166927 1.145537757 0.196025011 0.758379635 1 0.685155191 0.771737386 80320 Sp6 transcription factor "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005829,GO:0006357,GO:0042481,GO:0046872" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|cytosol|regulation of transcription by RNA polymerase II|regulation of odontogenesis|metal ion binding" SP9 6.524916457 7.282897178 5.766935736 0.791846376 -0.336707531 0.922510643 1 0.152182787 0.118488894 100131390 Sp9 transcription factor "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0030326,GO:0046872,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|embryonic limb morphogenesis|metal ion binding|sequence-specific double-stranded DNA binding" SPA17 82.27256904 65.54607461 98.99906347 1.510373643 0.594905494 0.237492522 1 2.634091516 3.911888218 53340 sperm autoantigenic protein 17 "GO:0003351,GO:0005515,GO:0005516,GO:0005576,GO:0005737,GO:0005929,GO:0007283,GO:0007338,GO:0007339,GO:0009897,GO:0031514,GO:0035686,GO:0097228" epithelial cilium movement involved in extracellular fluid movement|protein binding|calmodulin binding|extracellular region|cytoplasm|cilium|spermatogenesis|single fertilization|binding of sperm to zona pellucida|external side of plasma membrane|motile cilium|sperm fibrous sheath|sperm principal piece SPAAR 3.562190663 5.202069413 1.922311912 0.369528309 -1.436243205 0.543489417 1 0.172975005 0.062849561 158376 small regulatory polypeptide of amino acid response "GO:0031902,GO:0043416,GO:0046611,GO:0071230,GO:1904262,GO:1905103" late endosome membrane|regulation of skeletal muscle tissue regeneration|lysosomal proton-transporting V-type ATPase complex|cellular response to amino acid stimulus|negative regulation of TORC1 signaling|integral component of lysosomal membrane SPACA6 45.15923868 37.45489978 52.86357758 1.411392846 0.497119602 0.435545365 1 0.273222958 0.379172017 147650 sperm acrosome associated 6 "GO:0002080,GO:0005515,GO:0007342,GO:0016021" acrosomal membrane|protein binding|fusion of sperm to egg plasma membrane involved in single fertilization|integral component of membrane SPACA9 108.2086886 103.0009744 113.4164028 1.101119708 0.138971319 0.776995344 1 2.017978229 2.184852841 11092 sperm acrosome associated 9 "GO:0001669,GO:0005515,GO:0005634,GO:0005881,GO:0036064,GO:0036126,GO:0048306,GO:0097546" acrosomal vesicle|protein binding|nucleus|cytoplasmic microtubule|ciliary basal body|sperm flagellum|calcium-dependent protein binding|ciliary base SPAG1 737.8955172 775.1083426 700.6826919 0.903980326 -0.145636721 0.569352478 1 10.40656796 9.249913724 6674 sperm associated antigen 1 "GO:0005525,GO:0005737,GO:0005829,GO:0007338,GO:0016787,GO:0070286" GTP binding|cytoplasm|cytosol|single fertilization|hydrolase activity|axonemal dynein complex assembly SPAG16 400.1856344 337.094098 463.2771708 1.374325963 0.458724223 0.112704267 1 1.128046931 1.524361944 79582 sperm associated antigen 16 "GO:0005576,GO:0005930,GO:0007288,GO:0035082,GO:0036126,GO:0060271,GO:0090660,GO:0120197,GO:1990716" extracellular region|axoneme|sperm axoneme assembly|axoneme assembly|sperm flagellum|cilium assembly|cerebrospinal fluid circulation|mucociliary clearance|axonemal central apparatus SPAG4 282.8409338 246.5780902 319.1037774 1.294128676 0.371981073 0.248644347 1 8.318217119 10.58470823 6676 sperm associated antigen 4 "GO:0005198,GO:0005515,GO:0005635,GO:0005637,GO:0005737,GO:0005856,GO:0006998,GO:0007283,GO:0016021,GO:0030154,GO:0031514,GO:0034993,GO:0043495" structural molecule activity|protein binding|nuclear envelope|nuclear inner membrane|cytoplasm|cytoskeleton|nuclear envelope organization|spermatogenesis|integral component of membrane|cell differentiation|motile cilium|meiotic nuclear membrane microtubule tethering complex|protein-membrane adaptor activity SPAG5 2454.503965 2604.155948 2304.851982 0.885066804 -0.176141742 0.456518299 1 36.70866791 31.94595355 10615 sperm associated antigen 5 "GO:0000070,GO:0000776,GO:0000777,GO:0005515,GO:0005737,GO:0005829,GO:0007051,GO:0007059,GO:0008017,GO:0016604,GO:0030496,GO:0032388,GO:0034451,GO:0035371,GO:0051301,GO:0051988,GO:0071539,GO:0072686,GO:0090235,GO:0097431,GO:1905832" mitotic sister chromatid segregation|kinetochore|condensed chromosome kinetochore|protein binding|cytoplasm|cytosol|spindle organization|chromosome segregation|microtubule binding|nuclear body|midbody|positive regulation of intracellular transport|centriolar satellite|microtubule plus-end|cell division|regulation of attachment of spindle microtubules to kinetochore|protein localization to centrosome|mitotic spindle|regulation of metaphase plate congression|mitotic spindle pole|positive regulation of spindle assembly SPAG7 712.1279744 716.8451651 707.4107836 0.986839025 -0.019113327 0.946298842 1 21.88598911 21.23653573 9552 sperm associated antigen 7 "GO:0003676,GO:0005515,GO:0005634" nucleic acid binding|protein binding|nucleus SPAG8 8.006279355 8.323311061 7.689247648 0.923820772 -0.11431511 1 1 0.187742947 0.170538537 26206 sperm associated antigen 8 "GO:0001669,GO:0003674,GO:0005515,GO:0005634,GO:0005737,GO:0005819,GO:0007049,GO:0007283,GO:0007338,GO:0008017,GO:0008150,GO:0016020,GO:0030154,GO:0045944" acrosomal vesicle|molecular_function|protein binding|nucleus|cytoplasm|spindle|cell cycle|spermatogenesis|single fertilization|microtubule binding|biological_process|membrane|cell differentiation|positive regulation of transcription by RNA polymerase II SPAG9 4609.651166 4603.831431 4615.470901 1.002528214 0.003642838 0.98888425 1 28.02532474 27.62602725 9043 sperm associated antigen 9 "GO:0001669,GO:0001933,GO:0005078,GO:0005515,GO:0005737,GO:0005765,GO:0005829,GO:0007257,GO:0008432,GO:0016192,GO:0019894,GO:0030159,GO:0030335,GO:0032418,GO:0034451,GO:0042147,GO:0042802,GO:0045665,GO:0045666,GO:0048471,GO:0051146,GO:0051149,GO:0070062,GO:1903860" "acrosomal vesicle|negative regulation of protein phosphorylation|MAP-kinase scaffold activity|protein binding|cytoplasm|lysosomal membrane|cytosol|activation of JUN kinase activity|JUN kinase binding|vesicle-mediated transport|kinesin binding|signaling receptor complex adaptor activity|positive regulation of cell migration|lysosome localization|centriolar satellite|retrograde transport, endosome to Golgi|identical protein binding|negative regulation of neuron differentiation|positive regulation of neuron differentiation|perinuclear region of cytoplasm|striated muscle cell differentiation|positive regulation of muscle cell differentiation|extracellular exosome|negative regulation of dendrite extension" SPANXA1 15.41309384 13.52538047 17.30080721 1.279136453 0.355170173 0.762138602 1 1.726853343 2.171918427 30014 "sperm protein associated with the nucleus, X-linked, family member A1" "GO:0005515,GO:0005634,GO:0005737,GO:0007283" protein binding|nucleus|cytoplasm|spermatogenesis SPANXA2 3.443303773 2.080827765 4.80577978 2.309551929 1.207612985 0.648665767 1 0.272181258 0.618097701 728712 SPANX family member A2 "GO:0005515,GO:0005634,GO:0005737,GO:0007283" protein binding|nucleus|cytoplasm|spermatogenesis SPANXB1 148.3344345 109.2434577 187.4254114 1.715667148 0.778769686 0.056245699 1 12.51099261 21.10551633 728695 SPANX family member B1 "GO:0003674,GO:0005515,GO:0005634,GO:0005737,GO:0007286" molecular_function|protein binding|nucleus|cytoplasm|spermatid development SPANXC 21.97763926 21.84869154 22.10658699 1.011803702 0.016929423 1 1 2.857903213 2.843249422 64663 SPANX family member C "GO:0003674,GO:0005515,GO:0005634,GO:0005737,GO:0008150" molecular_function|protein binding|nucleus|cytoplasm|biological_process SPANXD 13.93173094 12.48496659 15.3784953 1.231761029 0.300722389 0.825910327 1 0.976979062 1.183267387 64648 SPANX family member D "GO:0005515,GO:0005634,GO:0005737" protein binding|nucleus|cytoplasm SPANXN1 4.523346619 5.202069413 3.844623824 0.739056617 -0.436243205 0.933440272 1 0.398314037 0.28945063 494118 SPANX family member N1 SPANXN3 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.127350864 0.173521006 139067 SPANX family member N3 GO:0005515 protein binding SPARC 4897.552088 5412.233018 4382.871159 0.809808289 -0.304347685 0.204535677 1 83.69774815 66.64493827 6678 secreted protein acidic and cysteine rich "GO:0001503,GO:0001937,GO:0002576,GO:0005201,GO:0005509,GO:0005515,GO:0005518,GO:0005576,GO:0005604,GO:0005615,GO:0005737,GO:0005739,GO:0005886,GO:0006898,GO:0007507,GO:0009629,GO:0009986,GO:0010288,GO:0010595,GO:0016363,GO:0016525,GO:0022604,GO:0030198,GO:0030324,GO:0031091,GO:0031092,GO:0031093,GO:0032496,GO:0033591,GO:0034097,GO:0042060,GO:0043231,GO:0043434,GO:0045471,GO:0046686,GO:0048839,GO:0048856,GO:0050807,GO:0050840,GO:0051384,GO:0051591,GO:0051592,GO:0062023,GO:0071682,GO:0098978" ossification|negative regulation of endothelial cell proliferation|platelet degranulation|extracellular matrix structural constituent|calcium ion binding|protein binding|collagen binding|extracellular region|basement membrane|extracellular space|cytoplasm|mitochondrion|plasma membrane|receptor-mediated endocytosis|heart development|response to gravity|cell surface|response to lead ion|positive regulation of endothelial cell migration|nuclear matrix|negative regulation of angiogenesis|regulation of cell morphogenesis|extracellular matrix organization|lung development|platelet alpha granule|platelet alpha granule membrane|platelet alpha granule lumen|response to lipopolysaccharide|response to L-ascorbic acid|response to cytokine|wound healing|intracellular membrane-bounded organelle|response to peptide hormone|response to ethanol|response to cadmium ion|inner ear development|anatomical structure development|regulation of synapse organization|extracellular matrix binding|response to glucocorticoid|response to cAMP|response to calcium ion|collagen-containing extracellular matrix|endocytic vesicle lumen|glutamatergic synapse SPART 1477.367361 1414.96288 1539.771842 1.088206527 0.121952386 0.611067962 1 13.83039713 14.79848156 23111 spartin "GO:0005515,GO:0005737,GO:0005741,GO:0005811,GO:0005829,GO:0005886,GO:0009838,GO:0030496,GO:0030514,GO:0031625,GO:0034389,GO:0045202,GO:0048698,GO:0050905,GO:0051301,GO:0051881,GO:0060612" protein binding|cytoplasm|mitochondrial outer membrane|lipid droplet|cytosol|plasma membrane|abscission|midbody|negative regulation of BMP signaling pathway|ubiquitin protein ligase binding|lipid droplet organization|synapse|negative regulation of collateral sprouting in absence of injury|neuromuscular process|cell division|regulation of mitochondrial membrane potential|adipose tissue development hsa04144 Endocytosis SPAST 460.5642381 471.3074888 449.8209874 0.954410864 -0.06731763 0.816066693 1 4.770114632 4.476466805 6683 spastin "GO:0000281,GO:0001578,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005783,GO:0005789,GO:0005811,GO:0005813,GO:0005819,GO:0005829,GO:0005874,GO:0006888,GO:0007409,GO:0008017,GO:0008089,GO:0008152,GO:0008568,GO:0010458,GO:0015630,GO:0016021,GO:0016853,GO:0016887,GO:0019896,GO:0030496,GO:0031117,GO:0031122,GO:0031410,GO:0031468,GO:0031965,GO:0032467,GO:0032506,GO:0034214,GO:0043014,GO:0044877,GO:0048471,GO:0048487,GO:0051013,GO:0051228,GO:0051260,GO:0061640,GO:0070062,GO:0090148,GO:1904115" mitotic cytokinesis|microtubule bundle formation|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|endosome|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|centrosome|spindle|cytosol|microtubule|endoplasmic reticulum to Golgi vesicle-mediated transport|axonogenesis|microtubule binding|anterograde axonal transport|metabolic process|microtubule-severing ATPase activity|exit from mitosis|microtubule cytoskeleton|integral component of membrane|isomerase activity|ATPase activity|axonal transport of mitochondrion|midbody|positive regulation of microtubule depolymerization|cytoplasmic microtubule organization|cytoplasmic vesicle|nuclear envelope reassembly|nuclear membrane|positive regulation of cytokinesis|cytokinetic process|protein hexamerization|alpha-tubulin binding|protein-containing complex binding|perinuclear region of cytoplasm|beta-tubulin binding|microtubule severing|mitotic spindle disassembly|protein homooligomerization|cytoskeleton-dependent cytokinesis|extracellular exosome|membrane fission|axon cytoplasm SPATA1 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.059789996 0.018103651 100505741 spermatogenesis associated 1 SPATA12 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.126407951 353324 spermatogenesis associated 12 GO:0005515 protein binding SPATA13 472.9944845 532.6919079 413.2970611 0.775865101 -0.36612226 0.186150275 1 3.093448104 2.35993603 221178 spermatogenesis associated 13 "GO:0005085,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0016477,GO:0030027,GO:0030032,GO:0030175,GO:0030334,GO:0032587,GO:0046847,GO:0050790" guanyl-nucleotide exchange factor activity|protein binding|nucleoplasm|cytoplasm|cytosol|cell migration|lamellipodium|lamellipodium assembly|filopodium|regulation of cell migration|ruffle membrane|filopodium assembly|regulation of catalytic activity hsa04810 Regulation of actin cytoskeleton SPATA17 24.65793189 29.13158871 20.18427508 0.692865579 -0.529352609 0.519783326 1 0.257485815 0.175417724 128153 spermatogenesis associated 17 "GO:0005515,GO:0005516,GO:0005737" protein binding|calmodulin binding|cytoplasm SPATA18 30.54375452 32.25283036 28.83467868 0.894020102 -0.161620825 0.865545159 1 0.38890065 0.341866961 132671 spermatogenesis associated 18 "GO:0005515,GO:0005737,GO:0005739,GO:0005741,GO:0006974,GO:0035694,GO:0035695,GO:0042802,GO:0043231" protein binding|cytoplasm|mitochondrion|mitochondrial outer membrane|cellular response to DNA damage stimulus|mitochondrial protein catabolic process|mitophagy by induced vacuole formation|identical protein binding|intracellular membrane-bounded organelle SPATA2 330.3382813 345.417409 315.2591536 0.912690401 -0.131802537 0.672708623 1 4.249491072 3.813568772 9825 spermatogenesis associated 2 "GO:0001650,GO:0005515,GO:0005654,GO:0005737,GO:0007283,GO:0010803,GO:0030159,GO:0044877,GO:0050727,GO:0060544,GO:0070266,GO:0070536,GO:0072520,GO:1990108,GO:1990381" fibrillar center|protein binding|nucleoplasm|cytoplasm|spermatogenesis|regulation of tumor necrosis factor-mediated signaling pathway|signaling receptor complex adaptor activity|protein-containing complex binding|regulation of inflammatory response|regulation of necroptotic process|necroptotic process|protein K63-linked deubiquitination|seminiferous tubule development|protein linear deubiquitination|ubiquitin-specific protease binding hsa04217 Necroptosis SPATA20 1969.595025 1922.684855 2016.505196 1.048796525 0.068734811 0.773148943 1 38.15922535 39.35156133 64847 spermatogenesis associated 20 "GO:0005576,GO:0005975,GO:0007275,GO:0007283,GO:0030154" extracellular region|carbohydrate metabolic process|multicellular organism development|spermatogenesis|cell differentiation SPATA21 7.406814487 5.202069413 9.61155956 1.847641543 0.88568489 0.555147706 1 0.039700398 0.072124657 374955 spermatogenesis associated 21 GO:0005509 calcium ion binding SPATA24 49.39512172 60.34400519 38.44623824 0.637117774 -0.65036801 0.283461704 1 1.339063888 0.838865237 202051 spermatogenesis associated 24 "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0007275,GO:0007283,GO:0030154" DNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|multicellular organism development|spermatogenesis|cell differentiation SPATA25 8.085537281 10.40413883 5.766935736 0.554292463 -0.851280704 0.546153423 1 0.185951027 0.101346495 128497 spermatogenesis associated 25 "GO:0003674,GO:0005515,GO:0005575,GO:0007283,GO:0016021,GO:0030154" molecular_function|protein binding|cellular_component|spermatogenesis|integral component of membrane|cell differentiation SPATA2L 166.3183806 202.8807071 129.7560541 0.639568227 -0.644829827 0.098064706 1 4.387103104 2.758899623 124044 spermatogenesis associated 2 like "GO:0005515,GO:0005737" protein binding|cytoplasm hsa04217 Necroptosis SPATA33 140.0010627 117.5667687 162.4353566 1.381643455 0.466385364 0.264220013 1 2.350813926 3.193636017 124045 spermatogenesis associated 33 "GO:0005515,GO:0005634,GO:0005737,GO:0005829" protein binding|nucleus|cytoplasm|cytosol SPATA4 10.85011826 7.282897178 14.41733934 1.979615939 0.985220564 0.397526524 1 0.340345742 0.662479497 132851 spermatogenesis associated 4 "GO:0003674,GO:0005515,GO:0005575,GO:0005634,GO:0005930,GO:0008017,GO:0051493" molecular_function|protein binding|cellular_component|nucleus|axoneme|microtubule binding|regulation of cytoskeleton organization SPATA5 213.5685079 219.5273292 207.6096865 0.945712259 -0.080526796 0.832360032 1 0.528618422 0.491555423 166378 spermatogenesis associated 5 "GO:0005524,GO:0005737,GO:0005739,GO:0005819,GO:0007283,GO:0007420,GO:0016887,GO:0030154" ATP binding|cytoplasm|mitochondrion|spindle|spermatogenesis|brain development|ATPase activity|cell differentiation hsa03008 Ribosome biogenesis in eukaryotes SPATA5L1 248.5217525 241.3760208 255.6674843 1.059208299 0.08298633 0.815471941 1 4.794117826 4.992996445 79029 spermatogenesis associated 5 like 1 "GO:0005524,GO:0005737,GO:0005819,GO:0016887" ATP binding|cytoplasm|spindle|ATPase activity SPATA6 53.12085865 57.22276355 49.01895376 0.856633807 -0.223249481 0.726827088 1 0.309943542 0.261065197 54558 spermatogenesis associated 6 "GO:0005576,GO:0007275,GO:0007283,GO:0030154,GO:0032027,GO:0044458,GO:0097224" extracellular region|multicellular organism development|spermatogenesis|cell differentiation|myosin light chain binding|motile cilium assembly|sperm connecting piece SPATA6L 41.87445076 39.53572754 44.21317398 1.118309355 0.161319333 0.83510873 1 0.394678099 0.433986444 55064 spermatogenesis associated 6 like "GO:0007283,GO:0032027,GO:0097224" spermatogenesis|myosin light chain binding|sperm connecting piece SPATA7 212.5727534 206.0019488 219.143558 1.063793616 0.089218284 0.81347831 1 3.660987476 3.829365334 55812 spermatogenesis associated 7 "GO:0000226,GO:0005515,GO:0005654,GO:0005739,GO:0005829,GO:0005930,GO:0007601,GO:0015630,GO:0032391,GO:0036064,GO:0045494,GO:0050896,GO:0120200,GO:0120206,GO:1903546,GO:1903621" microtubule cytoskeleton organization|protein binding|nucleoplasm|mitochondrion|cytosol|axoneme|visual perception|microtubule cytoskeleton|photoreceptor connecting cilium|ciliary basal body|photoreceptor cell maintenance|response to stimulus|rod photoreceptor outer segment|photoreceptor distal connecting cilium|protein localization to photoreceptor outer segment|protein localization to photoreceptor connecting cilium SPATA9 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.032328953 0.044049583 83890 spermatogenesis associated 9 "GO:0003674,GO:0005575,GO:0007275,GO:0007283,GO:0008150,GO:0016021,GO:0030154" molecular_function|cellular_component|multicellular organism development|spermatogenesis|biological_process|integral component of membrane|cell differentiation SPATC1L 444.839143 436.9738307 452.7044553 1.035999008 0.051022622 0.863738944 1 7.222201989 7.356989713 84221 spermatogenesis and centriole associated 1 like "GO:0003674,GO:0005515,GO:0005575,GO:0005813,GO:0007283,GO:0008150,GO:0008154,GO:0010739,GO:0034237,GO:0097224,GO:2000481" molecular_function|protein binding|cellular_component|centrosome|spermatogenesis|biological_process|actin polymerization or depolymerization|positive regulation of protein kinase A signaling|protein kinase A regulatory subunit binding|sperm connecting piece|positive regulation of cAMP-dependent protein kinase activity SPATS2 1984.433806 1870.664161 2098.203452 1.121635564 0.165604 0.484681312 1 29.04681645 32.03476115 65244 spermatogenesis associated serine rich 2 "GO:0003723,GO:0005737,GO:0005829" RNA binding|cytoplasm|cytosol SPATS2L 2566.805112 2688.429473 2445.180752 0.909520141 -0.136822509 0.563357553 1 36.07657527 32.2633012 26010 spermatogenesis associated serine rich 2 like "GO:0003723,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0032991" RNA binding|nucleoplasm|nucleolus|cytoplasm|cytosol|protein-containing complex SPC24 985.8674947 989.4336024 982.301387 0.992791618 -0.01043716 0.97075118 1 20.79726383 20.30184378 147841 SPC24 component of NDC80 kinetochore complex "GO:0000777,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0007049,GO:0031262,GO:0051301" condensed chromosome kinetochore|protein binding|nucleoplasm|nucleolus|cytosol|cell cycle|Ndc80 complex|cell division SPC25 701.2835009 596.1571548 806.4098471 1.352679978 0.435820562 0.088875552 1 18.78147087 24.98019599 57405 SPC25 component of NDC80 kinetochore complex "GO:0000777,GO:0005515,GO:0005634,GO:0005829,GO:0007052,GO:0007059,GO:0031262,GO:0051301" condensed chromosome kinetochore|protein binding|nucleus|cytosol|mitotic spindle organization|chromosome segregation|Ndc80 complex|cell division SPCS1 1332.937915 1155.899824 1509.976007 1.306320821 0.385509254 0.108644209 1 16.29377949 20.92872937 28972 signal peptidase complex subunit 1 "GO:0003674,GO:0005515,GO:0005787,GO:0005789,GO:0006465,GO:0006508,GO:0008233,GO:0019068,GO:0019082,GO:0030176,GO:0043022,GO:0045047" molecular_function|protein binding|signal peptidase complex|endoplasmic reticulum membrane|signal peptide processing|proteolysis|peptidase activity|virion assembly|viral protein processing|integral component of endoplasmic reticulum membrane|ribosome binding|protein targeting to ER hsa03060 Protein export SPCS2 1016.441432 946.7766332 1086.10623 1.147162057 0.198069212 0.420750689 1 18.77656217 21.17932098 9789 signal peptidase complex subunit 2 "GO:0005787,GO:0005789,GO:0006465,GO:0008233,GO:0016021,GO:0045047" signal peptidase complex|endoplasmic reticulum membrane|signal peptide processing|peptidase activity|integral component of membrane|protein targeting to ER hsa03060 Protein export SPCS3 3240.646593 3207.596 3273.697186 1.020607703 0.029428436 0.902455469 1 37.4662953 37.59852192 60559 signal peptidase complex subunit 3 "GO:0005515,GO:0005783,GO:0005787,GO:0005789,GO:0006465,GO:0006508,GO:0008233,GO:0016021,GO:0019082,GO:0045047" protein binding|endoplasmic reticulum|signal peptidase complex|endoplasmic reticulum membrane|signal peptide processing|proteolysis|peptidase activity|integral component of membrane|viral protein processing|protein targeting to ER hsa03060 Protein export SPDL1 1060.168383 1060.181746 1060.155019 0.99997479 -3.64E-05 1 1 18.85998376 18.54391997 54908 spindle apparatus coiled-coil protein 1 "GO:0000132,GO:0000922,GO:0000940,GO:0005515,GO:0005634,GO:0005815,GO:0005829,GO:0007080,GO:0007094,GO:0016477,GO:0019899,GO:0034501,GO:0043515,GO:0051301" establishment of mitotic spindle orientation|spindle pole|condensed chromosome outer kinetochore|protein binding|nucleus|microtubule organizing center|cytosol|mitotic metaphase plate congression|mitotic spindle assembly checkpoint|cell migration|enzyme binding|protein localization to kinetochore|kinetochore binding|cell division SPDYE18 9.685787068 14.56579436 4.80577978 0.32993599 -1.599741937 0.1811519 1 0.625885406 0.203046588 100505767 speedy/RINGO cell cycle regulator family member E18 "hsa04114,hsa04914" Oocyte meiosis|Progesterone-mediated oocyte maturation SPECC1 1648.149338 1671.945109 1624.353566 0.971535224 -0.041661792 0.863247324 1 10.15924372 9.704900978 92521 sperm antigen with calponin homology and coiled-coil domains 1 "GO:0001650,GO:0005654,GO:0005815,GO:0005829,GO:0016020,GO:0030036,GO:0031941,GO:0043231" fibrillar center|nucleoplasm|microtubule organizing center|cytosol|membrane|actin cytoskeleton organization|filamentous actin|intracellular membrane-bounded organelle SPECC1L 2225.868963 2405.436897 2046.30103 0.85069828 -0.233280558 0.323856501 1 17.93430374 15.00138144 23384 sperm antigen with calponin homology and coiled-coil domains 1 like "GO:0005515,GO:0005737,GO:0005815,GO:0005819,GO:0005921,GO:0007049,GO:0007155,GO:0015629,GO:0030036,GO:0031941,GO:0051301" protein binding|cytoplasm|microtubule organizing center|spindle|gap junction|cell cycle|cell adhesion|actin cytoskeleton|actin cytoskeleton organization|filamentous actin|cell division SPEF1 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.140569561 0.063844016 25876 sperm flagellar 1 "GO:0001578,GO:0003341,GO:0003674,GO:0003779,GO:0005515,GO:0005737,GO:0005874,GO:0005902,GO:0005930,GO:0007026,GO:0008017,GO:0016323,GO:0016324,GO:0016477,GO:0030027,GO:0030032,GO:0030175,GO:0046847,GO:0051493,GO:0060548,GO:0097542,GO:0097729,GO:1904158,GO:1990716,GO:2000095" "microtubule bundle formation|cilium movement|molecular_function|actin binding|protein binding|cytoplasm|microtubule|microvillus|axoneme|negative regulation of microtubule depolymerization|microtubule binding|basolateral plasma membrane|apical plasma membrane|cell migration|lamellipodium|lamellipodium assembly|filopodium|filopodium assembly|regulation of cytoskeleton organization|negative regulation of cell death|ciliary tip|9+2 motile cilium|axonemal central apparatus assembly|axonemal central apparatus|regulation of Wnt signaling pathway, planar cell polarity pathway" SPEF2 145.2773596 142.5367019 148.0180172 1.038455466 0.054439348 0.911842709 1 0.836201144 0.85382686 79925 sperm flagellar 2 "GO:0002177,GO:0003351,GO:0003674,GO:0005576,GO:0005737,GO:0005794,GO:0007283,GO:0007288,GO:0036126,GO:0048705,GO:0048854,GO:0060541,GO:0097225" manchette|epithelial cilium movement involved in extracellular fluid movement|molecular_function|extracellular region|cytoplasm|Golgi apparatus|spermatogenesis|sperm axoneme assembly|sperm flagellum|skeletal system morphogenesis|brain morphogenesis|respiratory system development|sperm midpiece SPEG 1429.736035 1350.45722 1509.014851 1.117410333 0.160159066 0.504227695 1 4.268622351 4.689986532 10290 striated muscle enriched protein kinase "GO:0004672,GO:0005515,GO:0005524,GO:0005634,GO:0006468,GO:0007517,GO:0008285,GO:0042692,GO:0106310,GO:0106311" protein kinase activity|protein binding|ATP binding|nucleus|protein phosphorylation|muscle organ development|negative regulation of cell population proliferation|muscle cell differentiation|protein serine kinase activity|protein threonine kinase activity SPEN 1875.835203 2337.809994 1413.860411 0.604779864 -0.725517988 0.002265462 0.306734565 10.07384923 5.990512083 23013 spen family transcriptional repressor "GO:0000122,GO:0000398,GO:0001085,GO:0003676,GO:0003677,GO:0003714,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0007219,GO:0016032,GO:0017053,GO:0045892,GO:0050769,GO:0070062" "negative regulation of transcription by RNA polymerase II|mRNA splicing, via spliceosome|RNA polymerase II transcription factor binding|nucleic acid binding|DNA binding|transcription corepressor activity|RNA binding|protein binding|nucleus|nucleoplasm|Notch signaling pathway|viral process|transcription repressor complex|negative regulation of transcription, DNA-templated|positive regulation of neurogenesis|extracellular exosome" SPG11 1065.667362 1128.849063 1002.485662 0.888059968 -0.171270995 0.484780967 1 7.183949408 6.273020936 80208 "SPG11 vesicle trafficking associated, spatacsin" "GO:0005515,GO:0005730,GO:0005737,GO:0005765,GO:0005829,GO:0005886,GO:0007268,GO:0008088,GO:0030424,GO:0030425,GO:0031410,GO:0045202,GO:0048489,GO:0048675,GO:0090389,GO:0090659" protein binding|nucleolus|cytoplasm|lysosomal membrane|cytosol|plasma membrane|chemical synaptic transmission|axo-dendritic transport|axon|dendrite|cytoplasmic vesicle|synapse|synaptic vesicle transport|axon extension|phagosome-lysosome fusion involved in apoptotic cell clearance|walking behavior "hsa05014,hsa05022" Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases SPG21 1198.088618 1173.58686 1222.590376 1.041755338 0.059016493 0.81042141 1 24.37998199 24.97297565 51324 "SPG21 abhydrolase domain containing, maspardin" "GO:0005515,GO:0005794,GO:0005829,GO:0010008,GO:0030140,GO:0042609,GO:0043231,GO:0050851" protein binding|Golgi apparatus|cytosol|endosome membrane|trans-Golgi network transport vesicle|CD4 receptor binding|intracellular membrane-bounded organelle|antigen receptor-mediated signaling pathway hsa04144 Endocytosis SPG7 1475.826862 1361.901772 1589.751951 1.167302946 0.223179027 0.350494033 1 12.21960231 14.02528942 6687 "SPG7 matrix AAA peptidase subunit, paraplegin" "GO:0004176,GO:0004222,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0005757,GO:0006508,GO:0006851,GO:0007399,GO:0008053,GO:0008233,GO:0008270,GO:0034982,GO:0042407,GO:0046902,GO:0051082,GO:0065003,GO:1902686" ATP-dependent peptidase activity|metalloendopeptidase activity|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|mitochondrial permeability transition pore complex|proteolysis|mitochondrial calcium ion transmembrane transport|nervous system development|mitochondrial fusion|peptidase activity|zinc ion binding|mitochondrial protein processing|cristae formation|regulation of mitochondrial membrane permeability|unfolded protein binding|protein-containing complex assembly|mitochondrial outer membrane permeabilization involved in programmed cell death SPHK1 1472.036958 1325.487286 1618.58663 1.22112573 0.288211751 0.227725678 1 30.01222755 36.03543685 8877 sphingosine kinase 1 "GO:0000287,GO:0001568,GO:0001727,GO:0003376,GO:0003677,GO:0003951,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005905,GO:0006457,GO:0006473,GO:0006665,GO:0006670,GO:0006954,GO:0007420,GO:0008289,GO:0008481,GO:0010800,GO:0010803,GO:0016020,GO:0016310,GO:0016407,GO:0017050,GO:0019722,GO:0030100,GO:0030139,GO:0030148,GO:0030307,GO:0030335,GO:0031398,GO:0031901,GO:0032651,GO:0032740,GO:0034612,GO:0035556,GO:0035924,GO:0038036,GO:0043066,GO:0043231,GO:0045766,GO:0045840,GO:0045931,GO:0045987,GO:0046512,GO:0046521,GO:0046834,GO:0048146,GO:0050764,GO:0051092,GO:0051721,GO:0070301,GO:0071363,GO:0071897,GO:0098793,GO:0150077,GO:1900060,GO:1900745,GO:1901224,GO:1903978,GO:1905364" magnesium ion binding|blood vessel development|lipid kinase activity|sphingosine-1-phosphate receptor signaling pathway|DNA binding|NAD+ kinase activity|protein binding|calmodulin binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|clathrin-coated pit|protein folding|protein acetylation|sphingolipid metabolic process|sphingosine metabolic process|inflammatory response|brain development|lipid binding|sphinganine kinase activity|positive regulation of peptidyl-threonine phosphorylation|regulation of tumor necrosis factor-mediated signaling pathway|membrane|phosphorylation|acetyltransferase activity|D-erythro-sphingosine kinase activity|calcium-mediated signaling|regulation of endocytosis|endocytic vesicle|sphingolipid biosynthetic process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of protein ubiquitination|early endosome membrane|regulation of interleukin-1 beta production|positive regulation of interleukin-17 production|response to tumor necrosis factor|intracellular signal transduction|cellular response to vascular endothelial growth factor stimulus|sphingosine-1-phosphate receptor activity|negative regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of angiogenesis|positive regulation of mitotic nuclear division|positive regulation of mitotic cell cycle|positive regulation of smooth muscle contraction|sphingosine biosynthetic process|sphingoid catabolic process|lipid phosphorylation|positive regulation of fibroblast proliferation|regulation of phagocytosis|positive regulation of NF-kappaB transcription factor activity|protein phosphatase 2A binding|cellular response to hydrogen peroxide|cellular response to growth factor stimulus|DNA biosynthetic process|presynapse|regulation of neuroinflammatory response|negative regulation of ceramide biosynthetic process|positive regulation of p38MAPK cascade|positive regulation of NIK/NF-kappaB signaling|regulation of microglial cell activation|regulation of endosomal vesicle fusion "hsa00600,hsa04020,hsa04071,hsa04072,hsa04370,hsa04371,hsa04666,hsa05152" Sphingolipid metabolism|Calcium signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|VEGF signaling pathway|Apelin signaling pathway|Fc gamma R-mediated phagocytosis|Tuberculosis SPHK2 118.7763737 115.485941 122.0668064 1.056984126 0.079953711 0.874740124 1 1.492317776 1.550961281 56848 sphingosine kinase 2 "GO:0000786,GO:0001727,GO:0002367,GO:0003376,GO:0003951,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005743,GO:0005765,GO:0005783,GO:0005829,GO:0006665,GO:0006669,GO:0006670,GO:0008481,GO:0016020,GO:0016310,GO:0017050,GO:0030148,GO:0030308,GO:0031064,GO:0031267,GO:0031493,GO:0032616,GO:0032635,GO:0032640,GO:0033008,GO:0038036,GO:0043065,GO:0043122,GO:0043231,GO:0043306,GO:0043977,GO:0043980,GO:0045815,GO:0046512,GO:0046834,GO:0090037,GO:0090280,GO:1901726,GO:1903426,GO:1904628,GO:1904959,GO:2000304,GO:2000617,GO:2001169" "nucleosome|lipid kinase activity|cytokine production involved in immune response|sphingosine-1-phosphate receptor signaling pathway|NAD+ kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial inner membrane|lysosomal membrane|endoplasmic reticulum|cytosol|sphingolipid metabolic process|sphinganine-1-phosphate biosynthetic process|sphingosine metabolic process|sphinganine kinase activity|membrane|phosphorylation|D-erythro-sphingosine kinase activity|sphingolipid biosynthetic process|negative regulation of cell growth|negative regulation of histone deacetylation|small GTPase binding|nucleosomal histone binding|interleukin-13 production|interleukin-6 production|tumor necrosis factor production|positive regulation of mast cell activation involved in immune response|sphingosine-1-phosphate receptor activity|positive regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|positive regulation of mast cell degranulation|histone H2A-K5 acetylation|histone H2B-K12 acetylation|positive regulation of gene expression, epigenetic|sphingosine biosynthetic process|lipid phosphorylation|positive regulation of protein kinase C signaling|positive regulation of calcium ion import|negative regulation of histone deacetylase activity|regulation of reactive oxygen species biosynthetic process|cellular response to phorbol 13-acetate 12-myristate|regulation of cytochrome-c oxidase activity|positive regulation of ceramide biosynthetic process|positive regulation of histone H3-K9 acetylation|regulation of ATP biosynthetic process" "hsa00600,hsa04020,hsa04071,hsa04072,hsa04370,hsa04371,hsa04666,hsa05152" Sphingolipid metabolism|Calcium signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|VEGF signaling pathway|Apelin signaling pathway|Fc gamma R-mediated phagocytosis|Tuberculosis SPICE1 604.8905026 588.8742576 620.9067476 1.054396146 0.076417002 0.776236153 1 5.556424473 5.760635599 152185 spindle and centriole associated protein 1 "GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0005819,GO:0046599,GO:0051301,GO:0051310,GO:0090307" protein binding|cytoplasm|centrosome|centriole|spindle|regulation of centriole replication|cell division|metaphase plate congression|mitotic spindle assembly SPIDR 1206.342732 1163.182721 1249.502743 1.0742102 0.103276325 0.671746118 1 14.3829759 15.1917989 23514 scaffold protein involved in DNA repair "GO:0000228,GO:0000724,GO:0005515,GO:0005654,GO:0006974,GO:0010569,GO:0031334,GO:0070202,GO:0071479,GO:0072711,GO:0072757,GO:2000781" nuclear chromosome|double-strand break repair via homologous recombination|protein binding|nucleoplasm|cellular response to DNA damage stimulus|regulation of double-strand break repair via homologous recombination|positive regulation of protein-containing complex assembly|regulation of establishment of protein localization to chromosome|cellular response to ionizing radiation|cellular response to hydroxyurea|cellular response to camptothecin|positive regulation of double-strand break repair SPIN1 2402.806562 2294.112611 2511.500513 1.094759037 0.130613359 0.581286225 1 27.45740607 29.5562427 10927 spindlin 1 "GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006325,GO:0006355,GO:0007275,GO:0007276,GO:0009303,GO:0016055,GO:0030177,GO:0031965,GO:0035064,GO:0045893,GO:0051321" "protein binding|nucleus|nucleoplasm|nucleolus|cytosol|chromatin organization|regulation of transcription, DNA-templated|multicellular organism development|gamete generation|rRNA transcription|Wnt signaling pathway|positive regulation of Wnt signaling pathway|nuclear membrane|methylated histone binding|positive regulation of transcription, DNA-templated|meiotic cell cycle" SPIN2B 82.06436338 85.31393838 78.81478839 0.923820772 -0.11431511 0.842022959 1 3.360183093 3.052262239 474343 spindlin family member 2B "GO:0005515,GO:0005654,GO:0005829,GO:0006355,GO:0006915,GO:0007049,GO:0007276,GO:0035064,GO:0051726" "protein binding|nucleoplasm|cytosol|regulation of transcription, DNA-templated|apoptotic process|cell cycle|gamete generation|methylated histone binding|regulation of cell cycle" SPIN3 326.9295761 356.8619617 296.9971904 0.832246701 -0.264916848 0.389594072 1 3.917126083 3.20546332 169981 spindlin family member 3 "GO:0005515,GO:0005654,GO:0005829,GO:0006355,GO:0007276,GO:0035064" "protein binding|nucleoplasm|cytosol|regulation of transcription, DNA-templated|gamete generation|methylated histone binding" SPIN4 605.524566 605.5208797 605.5282523 1.000012176 1.76E-05 1 1 7.872237868 7.740600874 139886 spindlin family member 4 "GO:0005515,GO:0005654,GO:0005829,GO:0006355,GO:0007276,GO:0035064" "protein binding|nucleoplasm|cytosol|regulation of transcription, DNA-templated|gamete generation|methylated histone binding" SPINDOC 990.8468816 956.1403581 1025.553405 1.072597131 0.1011083 0.683820772 1 18.3618041 19.36525229 144097 spindlin interactor and repressor of chromatin binding "GO:0005515,GO:0045892" "protein binding|negative regulation of transcription, DNA-templated" SPINK13 4.885037707 2.080827765 7.689247648 3.695283087 1.88568489 0.299624042 1 0.179112828 0.650797063 153218 serine peptidase inhibitor Kazal type 13 "GO:0004867,GO:0005515,GO:0005576,GO:0010951,GO:1902225" serine-type endopeptidase inhibitor activity|protein binding|extracellular region|negative regulation of endopeptidase activity|negative regulation of acrosome reaction SPINT1 354.7339017 329.8112008 379.6566026 1.151133138 0.203054703 0.501160761 1 5.884793587 6.660824167 6692 "serine peptidase inhibitor, Kunitz type 1" "GO:0001843,GO:0004867,GO:0005576,GO:0005615,GO:0005886,GO:0010951,GO:0016020,GO:0030198,GO:0045687,GO:0060670,GO:0060674,GO:0070062,GO:0071773,GO:2000178" neural tube closure|serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|plasma membrane|negative regulation of endopeptidase activity|membrane|extracellular matrix organization|positive regulation of glial cell differentiation|branching involved in labyrinthine layer morphogenesis|placenta blood vessel development|extracellular exosome|cellular response to BMP stimulus|negative regulation of neural precursor cell proliferation "hsa05202,hsa05215" Transcriptional misregulation in cancer|Prostate cancer SPINT2 1127.370656 957.180772 1297.560541 1.355606567 0.438938531 0.071324633 1 30.26242807 40.33746605 10653 "serine peptidase inhibitor, Kunitz type 2" "GO:0001843,GO:0004866,GO:0004867,GO:0005576,GO:0005737,GO:0005886,GO:0007163,GO:0010951,GO:0016021,GO:0022408,GO:0060672,GO:0071711,GO:0071773,GO:2000146,GO:2000178" neural tube closure|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|extracellular region|cytoplasm|plasma membrane|establishment or maintenance of cell polarity|negative regulation of endopeptidase activity|integral component of membrane|negative regulation of cell-cell adhesion|epithelial cell morphogenesis involved in placental branching|basement membrane organization|cellular response to BMP stimulus|negative regulation of cell motility|negative regulation of neural precursor cell proliferation SPIRE1 2229.020388 2336.76958 2121.271195 0.90777936 -0.139586408 0.555565017 1 18.56066345 16.56704221 56907 spire type actin nucleation factor 1 "GO:0003779,GO:0005515,GO:0005654,GO:0005829,GO:0005856,GO:0005938,GO:0015031,GO:0016192,GO:0030036,GO:0030041,GO:0030659,GO:0031307,GO:0032154,GO:0036089,GO:0040038,GO:0045010,GO:0046907,GO:0048193,GO:0048471,GO:0051295,GO:0051639,GO:0070649,GO:0090141,GO:2000781" actin binding|protein binding|nucleoplasm|cytosol|cytoskeleton|cell cortex|protein transport|vesicle-mediated transport|actin cytoskeleton organization|actin filament polymerization|cytoplasmic vesicle membrane|integral component of mitochondrial outer membrane|cleavage furrow|cleavage furrow formation|polar body extrusion after meiotic divisions|actin nucleation|intracellular transport|Golgi vesicle transport|perinuclear region of cytoplasm|establishment of meiotic spindle localization|actin filament network formation|formin-nucleated actin cable assembly|positive regulation of mitochondrial fission|positive regulation of double-strand break repair SPIRE2 87.63818472 67.62690237 107.6494671 1.591814253 0.670671999 0.172363367 1 1.104382952 1.728555234 84501 spire type actin nucleation factor 2 "GO:0003779,GO:0005829,GO:0005856,GO:0005938,GO:0015031,GO:0016192,GO:0030036,GO:0030041,GO:0030659,GO:0032154,GO:0036089,GO:0040038,GO:0045010,GO:0046907,GO:0048193,GO:0051295,GO:0051639,GO:0070649,GO:2000781" actin binding|cytosol|cytoskeleton|cell cortex|protein transport|vesicle-mediated transport|actin cytoskeleton organization|actin filament polymerization|cytoplasmic vesicle membrane|cleavage furrow|cleavage furrow formation|polar body extrusion after meiotic divisions|actin nucleation|intracellular transport|Golgi vesicle transport|establishment of meiotic spindle localization|actin filament network formation|formin-nucleated actin cable assembly|positive regulation of double-strand break repair SPNS1 551.9772352 612.8037769 491.1506935 0.801481179 -0.319259453 0.232714899 1 10.34943395 8.156072999 83985 sphingolipid transporter 1 (putative) "GO:0005515,GO:0005743,GO:0005765,GO:0006869,GO:0016021,GO:0022857,GO:0055085" protein binding|mitochondrial inner membrane|lysosomal membrane|lipid transport|integral component of membrane|transmembrane transporter activity|transmembrane transport SPNS2 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.047430219 0.071806339 124976 sphingolipid transporter 2 "GO:0001782,GO:0002920,GO:0003376,GO:0005886,GO:0006665,GO:0006869,GO:0010008,GO:0016021,GO:0022857,GO:0043029,GO:0046624,GO:0048073,GO:0048535,GO:0055085,GO:0060348,GO:0072676" B cell homeostasis|regulation of humoral immune response|sphingosine-1-phosphate receptor signaling pathway|plasma membrane|sphingolipid metabolic process|lipid transport|endosome membrane|integral component of membrane|transmembrane transporter activity|T cell homeostasis|sphingolipid transporter activity|regulation of eye pigmentation|lymph node development|transmembrane transport|bone development|lymphocyte migration SPNS3 3.641448589 7.282897178 0 0 #NAME? 0.060320757 1 0.140824216 0 201305 sphingolipid transporter 3 (putative) "GO:0006869,GO:0016021,GO:0022857,GO:0055085" lipid transport|integral component of membrane|transmembrane transporter activity|transmembrane transport SPOCD1 309.1387444 280.9117483 337.3657406 1.200967003 0.264196513 0.399476825 1 3.614210153 4.267913958 90853 SPOC domain containing 1 "GO:0005634,GO:0006306,GO:0006351,GO:0007283,GO:0010529,GO:0010923" "nucleus|DNA methylation|transcription, DNA-templated|spermatogenesis|negative regulation of transposition|negative regulation of phosphatase activity" SPOCK1 51.36209301 48.89945248 53.82473354 1.100722622 0.13845096 0.846163358 1 0.540977178 0.585501503 6695 "SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1" "GO:0001558,GO:0001764,GO:0004867,GO:0004869,GO:0005509,GO:0005515,GO:0005615,GO:0005737,GO:0007155,GO:0007399,GO:0008191,GO:0010812,GO:0010951,GO:0010977,GO:0014069,GO:0016528,GO:0021953,GO:0022008,GO:0031594,GO:0033268" regulation of cell growth|neuron migration|serine-type endopeptidase inhibitor activity|cysteine-type endopeptidase inhibitor activity|calcium ion binding|protein binding|extracellular space|cytoplasm|cell adhesion|nervous system development|metalloendopeptidase inhibitor activity|negative regulation of cell-substrate adhesion|negative regulation of endopeptidase activity|negative regulation of neuron projection development|postsynaptic density|sarcoplasm|central nervous system neuron differentiation|neurogenesis|neuromuscular junction|node of Ranvier SPOCK2 52.52139378 54.1015219 50.94126567 0.941586556 -0.086834373 0.915972431 1 0.374099351 0.346352544 9806 "SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2" "GO:0005509,GO:0005515,GO:0005539,GO:0007416,GO:0008191,GO:0010811,GO:0010951,GO:0019800,GO:0030198,GO:0031012,GO:0045595,GO:0050840,GO:1990830,GO:2000147" calcium ion binding|protein binding|glycosaminoglycan binding|synapse assembly|metalloendopeptidase inhibitor activity|positive regulation of cell-substrate adhesion|negative regulation of endopeptidase activity|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|extracellular matrix organization|extracellular matrix|regulation of cell differentiation|extracellular matrix binding|cellular response to leukemia inhibitory factor|positive regulation of cell motility SPOCK3 119.4601269 108.2030438 130.71721 1.208073317 0.272708013 0.544131972 1 1.616628661 1.92032504 50859 "SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3" "GO:0005509,GO:0005539,GO:0005576,GO:0008191,GO:0010951,GO:0019800,GO:2000146" calcium ion binding|glycosaminoglycan binding|extracellular region|metalloendopeptidase inhibitor activity|negative regulation of endopeptidase activity|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|negative regulation of cell motility SPON2 64.02066671 40.57614142 87.465192 2.155581801 1.108077311 0.044404431 1 1.059948161 2.246571848 10417 spondin 2 "GO:0005515,GO:0007155,GO:0031012,GO:0045087,GO:0046872,GO:0070062" protein binding|cell adhesion|extracellular matrix|innate immune response|metal ion binding|extracellular exosome SPOP 787.6177315 818.8057256 756.4297374 0.923820772 -0.11431511 0.653312873 1 12.26098672 11.13741298 8405 speckle type BTB/POZ protein "GO:0000209,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0016607,GO:0030162,GO:0031463,GO:0031625,GO:0043161" protein polyubiquitination|protein binding|nucleus|nucleoplasm|cytoplasm|nuclear speck|regulation of proteolysis|Cul3-RING ubiquitin ligase complex|ubiquitin protein ligase binding|proteasome-mediated ubiquitin-dependent protein catabolic process hsa04340 Hedgehog signaling pathway SPOPL 699.7675395 581.5913604 817.9437186 1.406389046 0.491995739 0.054890781 1 5.313895221 7.348346735 339745 speckle type BTB/POZ protein like "GO:0005515,GO:0005634,GO:0005737,GO:0016567,GO:0030162,GO:0031397,GO:0031463,GO:0031625,GO:0043161" protein binding|nucleus|cytoplasm|protein ubiquitination|regulation of proteolysis|negative regulation of protein ubiquitination|Cul3-RING ubiquitin ligase complex|ubiquitin protein ligase binding|proteasome-mediated ubiquitin-dependent protein catabolic process hsa04340 Hedgehog signaling pathway SPOUT1 687.4599816 712.6835096 662.2364537 0.929215346 -0.105915115 0.683918673 1 8.759698077 8.003439926 51490 SPOUT domain containing methyltransferase 1 "GO:0000776,GO:0000777,GO:0003723,GO:0005515,GO:0005737,GO:0007049,GO:0008168,GO:0010608,GO:0031616,GO:0032259,GO:0035196,GO:0035198,GO:0051301,GO:0051661,GO:0072686" kinetochore|condensed chromosome kinetochore|RNA binding|protein binding|cytoplasm|cell cycle|methyltransferase activity|posttranscriptional regulation of gene expression|spindle pole centrosome|methylation|production of miRNAs involved in gene silencing by miRNA|miRNA binding|cell division|maintenance of centrosome location|mitotic spindle SPP1 142.264944 164.3853935 120.1444945 0.730870864 -0.452311573 0.275633715 1 5.013112184 3.602626597 6696 secreted phosphoprotein 1 "GO:0001649,GO:0005125,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005794,GO:0006710,GO:0006954,GO:0007155,GO:0007165,GO:0007566,GO:0030198,GO:0031214,GO:0033280,GO:0042995,GO:0043687,GO:0044267,GO:0045780,GO:0045893,GO:0046697,GO:0048471,GO:0048545,GO:0048685,GO:0050840,GO:0070062,GO:0071394,GO:2000866" "osteoblast differentiation|cytokine activity|integrin binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|androgen catabolic process|inflammatory response|cell adhesion|signal transduction|embryo implantation|extracellular matrix organization|biomineral tissue development|response to vitamin D|cell projection|post-translational protein modification|cellular protein metabolic process|positive regulation of bone resorption|positive regulation of transcription, DNA-templated|decidualization|perinuclear region of cytoplasm|response to steroid hormone|negative regulation of collateral sprouting of intact axon in response to injury|extracellular matrix binding|extracellular exosome|cellular response to testosterone stimulus|positive regulation of estradiol secretion" "hsa04151,hsa04371,hsa04510,hsa04512,hsa04620,hsa04929,hsa05165" PI3K-Akt signaling pathway|Apelin signaling pathway|Focal adhesion|ECM-receptor interaction|Toll-like receptor signaling pathway|GnRH secretion|Human papillomavirus infection SPPL2A 817.5620212 847.9373144 787.186728 0.928354861 -0.107251717 0.672248132 1 6.173650208 5.635432001 84888 signal peptide peptidase like 2A "GO:0005515,GO:0005765,GO:0005770,GO:0005886,GO:0006509,GO:0010803,GO:0016020,GO:0030660,GO:0031293,GO:0031902,GO:0033619,GO:0042500,GO:0042803,GO:0043231,GO:0050776,GO:0070062,GO:0071458,GO:0071556" "protein binding|lysosomal membrane|late endosome|plasma membrane|membrane protein ectodomain proteolysis|regulation of tumor necrosis factor-mediated signaling pathway|membrane|Golgi-associated vesicle membrane|membrane protein intracellular domain proteolysis|late endosome membrane|membrane protein proteolysis|aspartic endopeptidase activity, intramembrane cleaving|protein homodimerization activity|intracellular membrane-bounded organelle|regulation of immune response|extracellular exosome|integral component of cytoplasmic side of endoplasmic reticulum membrane|integral component of lumenal side of endoplasmic reticulum membrane" SPPL2B 377.1719973 401.5997587 352.7442358 0.878347729 -0.187135894 0.528229764 1 3.914637628 3.380875882 56928 signal peptide peptidase like 2B "GO:0000139,GO:0005515,GO:0005654,GO:0005765,GO:0005813,GO:0005886,GO:0006509,GO:0010008,GO:0010803,GO:0015629,GO:0016020,GO:0030660,GO:0031293,GO:0033619,GO:0042500,GO:0042803,GO:0050776,GO:0071458,GO:0071556" "Golgi membrane|protein binding|nucleoplasm|lysosomal membrane|centrosome|plasma membrane|membrane protein ectodomain proteolysis|endosome membrane|regulation of tumor necrosis factor-mediated signaling pathway|actin cytoskeleton|membrane|Golgi-associated vesicle membrane|membrane protein intracellular domain proteolysis|membrane protein proteolysis|aspartic endopeptidase activity, intramembrane cleaving|protein homodimerization activity|regulation of immune response|integral component of cytoplasmic side of endoplasmic reticulum membrane|integral component of lumenal side of endoplasmic reticulum membrane" SPPL3 951.0677355 984.231533 917.903938 0.932609764 -0.10065456 0.686395245 1 12.58725808 11.54256353 121665 signal peptide peptidase like 3 "GO:0005515,GO:0005791,GO:0005794,GO:0005886,GO:0006465,GO:0006509,GO:0007204,GO:0016020,GO:0030660,GO:0032092,GO:0033116,GO:0033619,GO:0035307,GO:0042500,GO:0042803,GO:0043231,GO:0050852,GO:0070886,GO:0071458,GO:0071556" "protein binding|rough endoplasmic reticulum|Golgi apparatus|plasma membrane|signal peptide processing|membrane protein ectodomain proteolysis|positive regulation of cytosolic calcium ion concentration|membrane|Golgi-associated vesicle membrane|positive regulation of protein binding|endoplasmic reticulum-Golgi intermediate compartment membrane|membrane protein proteolysis|positive regulation of protein dephosphorylation|aspartic endopeptidase activity, intramembrane cleaving|protein homodimerization activity|intracellular membrane-bounded organelle|T cell receptor signaling pathway|positive regulation of calcineurin-NFAT signaling cascade|integral component of cytoplasmic side of endoplasmic reticulum membrane|integral component of lumenal side of endoplasmic reticulum membrane" SPR 416.4108148 422.4080364 410.4135932 0.971604605 -0.041558767 0.892910237 1 15.74241658 15.03945656 6697 sepiapterin reductase "GO:0004033,GO:0004757,GO:0005654,GO:0005829,GO:0006729,GO:0006809,GO:0050661,GO:0050999,GO:0055114,GO:0070062" aldo-keto reductase (NADP) activity|sepiapterin reductase activity|nucleoplasm|cytosol|tetrahydrobiopterin biosynthetic process|nitric oxide biosynthetic process|NADP binding|regulation of nitric-oxide synthase activity|oxidation-reduction process|extracellular exosome hsa00790 Folate biosynthesis SPRED1 1043.175161 992.554844 1093.795478 1.10200004 0.140124276 0.56907839 1 5.960484729 6.458540221 161742 sprouty related EVH1 domain containing 1 "GO:0000165,GO:0000188,GO:0005173,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0005901,GO:0006469,GO:0008543,GO:0010719,GO:0010801,GO:0010923,GO:0016525,GO:0019901,GO:0019902,GO:0030291,GO:0030512,GO:0031410,GO:0043408,GO:0043409,GO:0043517,GO:0060979,GO:0070373,GO:0090051,GO:0090311,GO:1902747" "MAPK cascade|inactivation of MAPK activity|stem cell factor receptor binding|protein binding|nucleoplasm|cytosol|plasma membrane|caveola|negative regulation of protein kinase activity|fibroblast growth factor receptor signaling pathway|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-threonine phosphorylation|negative regulation of phosphatase activity|negative regulation of angiogenesis|protein kinase binding|phosphatase binding|protein serine/threonine kinase inhibitor activity|negative regulation of transforming growth factor beta receptor signaling pathway|cytoplasmic vesicle|regulation of MAPK cascade|negative regulation of MAPK cascade|positive regulation of DNA damage response, signal transduction by p53 class mediator|vasculogenesis involved in coronary vascular morphogenesis|negative regulation of ERK1 and ERK2 cascade|negative regulation of cell migration involved in sprouting angiogenesis|regulation of protein deacetylation|negative regulation of lens fiber cell differentiation" SPRED2 1253.423668 1301.557767 1205.289569 0.926036169 -0.110859551 0.647836679 1 11.2197942 10.21607374 200734 sprouty related EVH1 domain containing 2 "GO:0000188,GO:0005173,GO:0005515,GO:0005829,GO:0005886,GO:0007275,GO:0008543,GO:0010719,GO:0010801,GO:0019901,GO:0030291,GO:0030512,GO:0030658,GO:0043517,GO:0070373,GO:0090311,GO:1902747" "inactivation of MAPK activity|stem cell factor receptor binding|protein binding|cytosol|plasma membrane|multicellular organism development|fibroblast growth factor receptor signaling pathway|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-threonine phosphorylation|protein kinase binding|protein serine/threonine kinase inhibitor activity|negative regulation of transforming growth factor beta receptor signaling pathway|transport vesicle membrane|positive regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of ERK1 and ERK2 cascade|regulation of protein deacetylation|negative regulation of lens fiber cell differentiation" SPRED3 220.3362285 220.5677431 220.1047139 0.997900739 -0.003031776 1 1 2.257632348 2.215193876 399473 sprouty related EVH1 domain containing 3 "GO:0000188,GO:0005886,GO:0007275,GO:0010719,GO:0010801,GO:0019901,GO:0030512,GO:0043517,GO:0070373,GO:0090311,GO:1902747" "inactivation of MAPK activity|plasma membrane|multicellular organism development|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-threonine phosphorylation|protein kinase binding|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of ERK1 and ERK2 cascade|regulation of protein deacetylation|negative regulation of lens fiber cell differentiation" SPRING1 1536.338829 1562.701652 1509.976007 0.966259942 -0.049516742 0.837873331 1 9.897758726 9.403770399 79794 SREBF pathway regulator in golgi 1 "GO:0000139,GO:0005515,GO:0016021,GO:2000640" Golgi membrane|protein binding|integral component of membrane|positive regulation of SREBP signaling pathway SPRTN 367.5308696 375.5894116 359.4723275 0.957088556 -0.063275677 0.839269525 1 5.330988456 5.016849166 83932 SprT-like N-terminal domain "GO:0000785,GO:0003690,GO:0003697,GO:0004222,GO:0005515,GO:0005634,GO:0005654,GO:0006508,GO:0006974,GO:0009411,GO:0016540,GO:0016607,GO:0019985,GO:0031398,GO:0031593,GO:0043130,GO:0046872,GO:0070530,GO:0070987,GO:0106300" chromatin|double-stranded DNA binding|single-stranded DNA binding|metalloendopeptidase activity|protein binding|nucleus|nucleoplasm|proteolysis|cellular response to DNA damage stimulus|response to UV|protein autoprocessing|nuclear speck|translesion synthesis|positive regulation of protein ubiquitination|polyubiquitin modification-dependent protein binding|ubiquitin binding|metal ion binding|K63-linked polyubiquitin modification-dependent protein binding|error-free translesion synthesis|protein-DNA covalent cross-linking repair SPRY1 23.93958014 22.88910542 24.99005486 1.091788185 0.12669299 0.928499056 1 0.40909226 0.439168145 10252 sprouty RTK signaling antagonist 1 "GO:0000132,GO:0001656,GO:0001657,GO:0001759,GO:0005515,GO:0005654,GO:0005794,GO:0005829,GO:0005886,GO:0008285,GO:0010719,GO:0030512,GO:0034260,GO:0040037,GO:0042059,GO:0043407,GO:0046580,GO:0048513,GO:0051387,GO:0060449,GO:0060940,GO:0070373,GO:1902747" establishment of mitotic spindle orientation|metanephros development|ureteric bud development|organ induction|protein binding|nucleoplasm|Golgi apparatus|cytosol|plasma membrane|negative regulation of cell population proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of GTPase activity|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of Ras protein signal transduction|animal organ development|negative regulation of neurotrophin TRK receptor signaling pathway|bud elongation involved in lung branching|epithelial to mesenchymal transition involved in cardiac fibroblast development|negative regulation of ERK1 and ERK2 cascade|negative regulation of lens fiber cell differentiation SPRY2 1817.854343 1421.205364 2214.503323 1.558186719 0.639868123 0.007083715 0.504530246 21.89581934 33.54686014 10253 sprouty RTK signaling antagonist 2 "GO:0000132,GO:0005515,GO:0005634,GO:0005829,GO:0005856,GO:0005886,GO:0007605,GO:0008285,GO:0010628,GO:0010719,GO:0010801,GO:0015629,GO:0015630,GO:0016020,GO:0016525,GO:0019901,GO:0030291,GO:0030335,GO:0030512,GO:0031345,GO:0031397,GO:0032587,GO:0033138,GO:0034260,GO:0035924,GO:0040037,GO:0042059,GO:0042472,GO:0043066,GO:0043407,GO:0043539,GO:0045165,GO:0046580,GO:0048513,GO:0051387,GO:0051897,GO:0060437,GO:0060449,GO:0070373,GO:0070374,GO:0071902,GO:1900747,GO:1902747,GO:1990752,GO:1990830" establishment of mitotic spindle orientation|protein binding|nucleus|cytosol|cytoskeleton|plasma membrane|sensory perception of sound|negative regulation of cell population proliferation|positive regulation of gene expression|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-threonine phosphorylation|actin cytoskeleton|microtubule cytoskeleton|membrane|negative regulation of angiogenesis|protein kinase binding|protein serine/threonine kinase inhibitor activity|positive regulation of cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of cell projection organization|negative regulation of protein ubiquitination|ruffle membrane|positive regulation of peptidyl-serine phosphorylation|negative regulation of GTPase activity|cellular response to vascular endothelial growth factor stimulus|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|inner ear morphogenesis|negative regulation of apoptotic process|negative regulation of MAP kinase activity|protein serine/threonine kinase activator activity|cell fate commitment|negative regulation of Ras protein signal transduction|animal organ development|negative regulation of neurotrophin TRK receptor signaling pathway|positive regulation of protein kinase B signaling|lung growth|bud elongation involved in lung branching|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein serine/threonine kinase activity|negative regulation of vascular endothelial growth factor signaling pathway|negative regulation of lens fiber cell differentiation|microtubule end|cellular response to leukemia inhibitory factor hsa05206 MicroRNAs in cancer SPRY3 7.966650391 7.282897178 8.650403604 1.187769564 0.248254969 0.952730603 1 0.042441017 0.049566603 10251 sprouty RTK signaling antagonist 3 "GO:0003674,GO:0005515,GO:0005829,GO:0007275,GO:0016020,GO:0040037,GO:0043407,GO:0043409,GO:0046580,GO:0048513,GO:0061564,GO:0070373,GO:0150013" molecular_function|protein binding|cytosol|multicellular organism development|membrane|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of MAPK cascade|negative regulation of Ras protein signal transduction|animal organ development|axon development|negative regulation of ERK1 and ERK2 cascade|negative regulation of neuron projection arborization SPRY4 1634.337722 1460.741091 1807.934353 1.237682957 0.307641803 0.195829114 1 10.88633812 13.24836878 81848 sprouty RTK signaling antagonist 4 "GO:0004860,GO:0005515,GO:0005737,GO:0005829,GO:0005925,GO:0032587,GO:0040037,GO:0043407,GO:0046580,GO:0048513,GO:0070373,GO:1900025" protein kinase inhibitor activity|protein binding|cytoplasm|cytosol|focal adhesion|ruffle membrane|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of Ras protein signal transduction|animal organ development|negative regulation of ERK1 and ERK2 cascade|negative regulation of substrate adhesion-dependent cell spreading SPRYD3 855.2647555 904.119664 806.4098471 0.891928225 -0.165000476 0.510471939 1 16.62687966 14.58182357 84926 SPRY domain containing 3 "GO:0005737,GO:0007010,GO:0007166" cytoplasm|cytoskeleton organization|cell surface receptor signaling pathway SPRYD4 196.5947932 202.8807071 190.3088793 0.938033399 -0.092288804 0.813078405 1 1.00542023 0.927335958 283377 SPRY domain containing 4 "GO:0003674,GO:0005515,GO:0005634,GO:0008150" molecular_function|protein binding|nucleus|biological_process SPRYD7 501.1605012 502.5199053 499.8010971 0.994589651 -0.007826676 0.985409708 1 6.183666994 6.047295741 57213 SPRY domain containing 7 GO:0005515 protein binding SPSB1 775.0233245 866.6647642 683.3818847 0.78851929 -0.342782046 0.174763638 1 14.89127676 11.54557152 80176 splA/ryanodine receptor domain and SOCS box containing 1 "GO:0000209,GO:0005515,GO:0005829,GO:0006511,GO:0016567,GO:0019005,GO:0043161,GO:0043687,GO:1990756" protein polyubiquitination|protein binding|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|SCF ubiquitin ligase complex|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|ubiquitin ligase-substrate adaptor activity SPSB2 217.6062461 237.2143652 197.9981269 0.834680171 -0.260704597 0.463344569 1 8.724806817 7.160561755 84727 splA/ryanodine receptor domain and SOCS box containing 2 "GO:0005515,GO:0005829,GO:0006511,GO:0016032,GO:0016567,GO:0019005,GO:0035556,GO:0043161,GO:0043687,GO:1990756" protein binding|cytosol|ubiquitin-dependent protein catabolic process|viral process|protein ubiquitination|SCF ubiquitin ligase complex|intracellular signal transduction|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|ubiquitin ligase-substrate adaptor activity SPSB3 480.5006786 490.0349387 470.9664184 0.961087427 -0.057260421 0.84256233 1 14.91857617 14.09812804 90864 splA/ryanodine receptor domain and SOCS box containing 3 "GO:0005515,GO:0005829,GO:0016567,GO:0019005,GO:0043161,GO:0043687" protein binding|cytosol|protein ubiquitination|SCF ubiquitin ligase complex|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification SPTAN1 7176.577123 7787.497912 6565.656335 0.843102163 -0.246220634 0.314591645 1 51.91162262 43.03442318 6709 "spectrin alpha, non-erythrocytic 1" "GO:0000165,GO:0003779,GO:0005200,GO:0005509,GO:0005515,GO:0005516,GO:0005576,GO:0005829,GO:0006888,GO:0007010,GO:0007411,GO:0008091,GO:0015630,GO:0016020,GO:0035580,GO:0043231,GO:0043312,GO:0045296,GO:0051693,GO:0070062,GO:1903561,GO:1904724" MAPK cascade|actin binding|structural constituent of cytoskeleton|calcium ion binding|protein binding|calmodulin binding|extracellular region|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|cytoskeleton organization|axon guidance|spectrin|microtubule cytoskeleton|membrane|specific granule lumen|intracellular membrane-bounded organelle|neutrophil degranulation|cadherin binding|actin filament capping|extracellular exosome|extracellular vesicle|tertiary granule lumen hsa04210 Apoptosis SPTB 20.21887362 13.52538047 26.91236677 1.989767816 0.992600094 0.249662632 1 0.054166644 0.105975508 6710 "spectrin beta, erythrocytic" "GO:0000165,GO:0003779,GO:0005200,GO:0005515,GO:0005829,GO:0006888,GO:0007010,GO:0007411,GO:0008091,GO:0014731,GO:0015629,GO:0030506,GO:0031235,GO:0032991,GO:0051015,GO:0051693" MAPK cascade|actin binding|structural constituent of cytoskeleton|protein binding|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|cytoskeleton organization|axon guidance|spectrin|spectrin-associated cytoskeleton|actin cytoskeleton|ankyrin binding|intrinsic component of the cytoplasmic side of the plasma membrane|protein-containing complex|actin filament binding|actin filament capping SPTBN1 6286.284281 6947.883908 5624.684654 0.809553632 -0.304801434 0.209475357 1 29.47971017 23.46605119 6711 "spectrin beta, non-erythrocytic 1" "GO:0000165,GO:0000281,GO:0003723,GO:0003779,GO:0005200,GO:0005515,GO:0005516,GO:0005543,GO:0005730,GO:0005737,GO:0005829,GO:0006888,GO:0007009,GO:0007010,GO:0007411,GO:0008091,GO:0014731,GO:0030506,GO:0030673,GO:0031430,GO:0032743,GO:0043001,GO:0045296,GO:0051020,GO:0051693,GO:0070062,GO:0071709,GO:0072659,GO:1903076,GO:1903078" MAPK cascade|mitotic cytokinesis|RNA binding|actin binding|structural constituent of cytoskeleton|protein binding|calmodulin binding|phospholipid binding|nucleolus|cytoplasm|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|plasma membrane organization|cytoskeleton organization|axon guidance|spectrin|spectrin-associated cytoskeleton|ankyrin binding|axolemma|M band|positive regulation of interleukin-2 production|Golgi to plasma membrane protein transport|cadherin binding|GTPase binding|actin filament capping|extracellular exosome|membrane assembly|protein localization to plasma membrane|regulation of protein localization to plasma membrane|positive regulation of protein localization to plasma membrane SPTBN2 161.7755267 146.6983575 176.8526959 1.205553348 0.269695494 0.500329452 1 0.496922991 0.589042597 6712 "spectrin beta, non-erythrocytic 2" "GO:0000165,GO:0003779,GO:0005200,GO:0005543,GO:0005615,GO:0005829,GO:0006888,GO:0007010,GO:0007411,GO:0007416,GO:0008091,GO:0016192,GO:0016324,GO:0019886,GO:0021692,GO:0030534,GO:0035264,GO:0043025,GO:0045296,GO:0051693,GO:0098688,GO:0098793,GO:0098918,GO:0098978,GO:0099173,GO:0099189" MAPK cascade|actin binding|structural constituent of cytoskeleton|phospholipid binding|extracellular space|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|cytoskeleton organization|axon guidance|synapse assembly|spectrin|vesicle-mediated transport|apical plasma membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|cerebellar Purkinje cell layer morphogenesis|adult behavior|multicellular organism growth|neuronal cell body|cadherin binding|actin filament capping|parallel fiber to Purkinje cell synapse|presynapse|structural constituent of synapse|glutamatergic synapse|postsynapse organization|postsynaptic spectrin-associated cytoskeleton "hsa05017,hsa05022" Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases SPTBN4 48.99883208 49.93986637 48.0577978 0.962313304 -0.055421421 0.963972732 1 0.249293694 0.235884259 57731 "spectrin beta, non-erythrocytic 4" "GO:0000165,GO:0002028,GO:0003779,GO:0005200,GO:0005515,GO:0005543,GO:0005737,GO:0005829,GO:0005884,GO:0005886,GO:0005912,GO:0006888,GO:0007010,GO:0007409,GO:0007411,GO:0007605,GO:0007628,GO:0008091,GO:0009566,GO:0010459,GO:0014704,GO:0016020,GO:0016192,GO:0016363,GO:0016605,GO:0019226,GO:0019902,GO:0021952,GO:0030506,GO:0030507,GO:0033135,GO:0033268,GO:0033270,GO:0040018,GO:0043025,GO:0043194,GO:0043203,GO:0045162,GO:0051693,GO:0061337,GO:0070062,GO:0070852,GO:0072659,GO:0106006" MAPK cascade|regulation of sodium ion transport|actin binding|structural constituent of cytoskeleton|protein binding|phospholipid binding|cytoplasm|cytosol|actin filament|plasma membrane|adherens junction|endoplasmic reticulum to Golgi vesicle-mediated transport|cytoskeleton organization|axonogenesis|axon guidance|sensory perception of sound|adult walking behavior|spectrin|fertilization|negative regulation of heart rate|intercalated disc|membrane|vesicle-mediated transport|nuclear matrix|PML body|transmission of nerve impulse|phosphatase binding|central nervous system projection neuron axonogenesis|ankyrin binding|spectrin binding|regulation of peptidyl-serine phosphorylation|node of Ranvier|paranode region of axon|positive regulation of multicellular organism growth|neuronal cell body|axon initial segment|axon hillock|clustering of voltage-gated sodium channels|actin filament capping|cardiac conduction|extracellular exosome|cell body fiber|protein localization to plasma membrane|cytoskeletal protein-membrane anchor activity SPTBN5 12.52962597 13.52538047 11.53387147 0.852757635 -0.229792327 0.900893758 1 0.056072764 0.047016334 51332 "spectrin beta, non-erythrocytic 5" "GO:0000165,GO:0002046,GO:0003779,GO:0005737,GO:0005829,GO:0005875,GO:0006888,GO:0007030,GO:0007041,GO:0007411,GO:0008022,GO:0008091,GO:0016020,GO:0019894,GO:0030036,GO:0030507,GO:0032029,GO:0032391,GO:0034452,GO:0042802,GO:0043621,GO:0045179,GO:0045505,GO:0051015,GO:0051693,GO:0097381" MAPK cascade|opsin binding|actin binding|cytoplasm|cytosol|microtubule associated complex|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|lysosomal transport|axon guidance|protein C-terminus binding|spectrin|membrane|kinesin binding|actin cytoskeleton organization|spectrin binding|myosin tail binding|photoreceptor connecting cilium|dynactin binding|identical protein binding|protein self-association|apical cortex|dynein intermediate chain binding|actin filament binding|actin filament capping|photoreceptor disc membrane SPTLC1 2038.903279 1761.420703 2316.385854 1.315066781 0.395136063 0.094976942 1 18.77072396 24.27168957 10558 serine palmitoyltransferase long chain base subunit 1 "GO:0004758,GO:0005515,GO:0005783,GO:0005789,GO:0006665,GO:0016021,GO:0017059,GO:0030148,GO:0030170,GO:0035339,GO:0046512,GO:0046513,GO:1904504,GO:1904649" serine C-palmitoyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|sphingolipid metabolic process|integral component of membrane|serine C-palmitoyltransferase complex|sphingolipid biosynthetic process|pyridoxal phosphate binding|SPOTS complex|sphingosine biosynthetic process|ceramide biosynthetic process|positive regulation of lipophagy|regulation of fat cell apoptotic process "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway SPTLC2 2735.691772 2580.226429 2891.157116 1.120505194 0.164149336 0.488055985 1 16.26528966 17.92036514 9517 serine palmitoyltransferase long chain base subunit 2 "GO:0004758,GO:0005789,GO:0006686,GO:0016021,GO:0017059,GO:0030148,GO:0030170,GO:0046511,GO:0046512,GO:0046513,GO:0060612,GO:1904504" serine C-palmitoyltransferase activity|endoplasmic reticulum membrane|sphingomyelin biosynthetic process|integral component of membrane|serine C-palmitoyltransferase complex|sphingolipid biosynthetic process|pyridoxal phosphate binding|sphinganine biosynthetic process|sphingosine biosynthetic process|ceramide biosynthetic process|adipose tissue development|positive regulation of lipophagy "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway SPTLC3 25.09385049 40.57614142 9.61155956 0.236877121 -2.077789234 0.010079044 0.610531935 0.32825134 0.076454104 55304 serine palmitoyltransferase long chain base subunit 3 "GO:0004758,GO:0005515,GO:0005789,GO:0016021,GO:0017059,GO:0030148,GO:0030170,GO:0046512,GO:0046513,GO:0046520" serine C-palmitoyltransferase activity|protein binding|endoplasmic reticulum membrane|integral component of membrane|serine C-palmitoyltransferase complex|sphingolipid biosynthetic process|pyridoxal phosphate binding|sphingosine biosynthetic process|ceramide biosynthetic process|sphingoid biosynthetic process "hsa00600,hsa04071" Sphingolipid metabolism|Sphingolipid signaling pathway SPTSSA 793.0034689 770.946687 815.0602507 1.057219992 0.080275612 0.753904972 1 15.45605099 16.06701088 171546 serine palmitoyltransferase small subunit A "GO:0004758,GO:0005515,GO:0005783,GO:0005789,GO:0008104,GO:0016021,GO:0017059,GO:0030148,GO:0046513" serine C-palmitoyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein localization|integral component of membrane|serine C-palmitoyltransferase complex|sphingolipid biosynthetic process|ceramide biosynthetic process SPTSSB 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.02339207 0.021248465 165679 serine palmitoyltransferase small subunit B "GO:0004758,GO:0005515,GO:0005789,GO:0007029,GO:0016021,GO:0017059,GO:0030148,GO:0046513,GO:1904220" serine C-palmitoyltransferase activity|protein binding|endoplasmic reticulum membrane|endoplasmic reticulum organization|integral component of membrane|serine C-palmitoyltransferase complex|sphingolipid biosynthetic process|ceramide biosynthetic process|regulation of serine C-palmitoyltransferase activity SPTY2D1 1054.604622 1052.898849 1056.310396 1.003240146 0.004666986 0.989202839 1 9.79454008 9.661846405 144108 SPT2 chromatin protein domain containing 1 "GO:0001042,GO:0003677,GO:0005654,GO:0005730,GO:0006334,GO:0006355,GO:0010847,GO:0042393,GO:0043486" "RNA polymerase I core binding|DNA binding|nucleoplasm|nucleolus|nucleosome assembly|regulation of transcription, DNA-templated|regulation of chromatin assembly|histone binding|histone exchange" SPTY2D1OS 14.37267996 11.44455271 17.30080721 1.511706717 0.596178273 0.578096882 1 1.33356931 1.982231228 100506540 SPTY2D1 opposite strand GO:0016021 integral component of membrane SPX 60.43835437 85.31393838 35.56277037 0.416845958 -1.262413749 0.024815277 0.86041596 1.996950917 0.818491481 80763 spexin hormone "GO:0003084,GO:0005184,GO:0005515,GO:0005615,GO:0005737,GO:0007165,GO:0010459,GO:0030133,GO:0031045,GO:0032099,GO:0035814,GO:0044539,GO:0051930,GO:1904306" positive regulation of systemic arterial blood pressure|neuropeptide hormone activity|protein binding|extracellular space|cytoplasm|signal transduction|negative regulation of heart rate|transport vesicle|dense core granule|negative regulation of appetite|negative regulation of renal sodium excretion|long-chain fatty acid import into cell|regulation of sensory perception of pain|positive regulation of gastro-intestinal system smooth muscle contraction SQLE 1275.273588 1143.414857 1407.13232 1.230640227 0.299409057 0.214227937 1 18.62128453 22.5326319 6713 squalene epoxidase "GO:0004506,GO:0005515,GO:0005783,GO:0005789,GO:0006695,GO:0006725,GO:0008203,GO:0010033,GO:0016021,GO:0016126,GO:0042127,GO:0043231,GO:0045540,GO:0055114,GO:0071949,GO:0140042" squalene monooxygenase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol biosynthetic process|cellular aromatic compound metabolic process|cholesterol metabolic process|response to organic substance|integral component of membrane|sterol biosynthetic process|regulation of cell population proliferation|intracellular membrane-bounded organelle|regulation of cholesterol biosynthetic process|oxidation-reduction process|FAD binding|lipid droplet formation hsa00100 Steroid biosynthesis SQOR 1639.216501 1677.147179 1601.285823 0.954767621 -0.066778453 0.780832936 1 47.68580845 44.767002 58472 sulfide quinone oxidoreductase "GO:0005739,GO:0005743,GO:0048038,GO:0070221,GO:0070224,GO:0070813,GO:0071949" "mitochondrion|mitochondrial inner membrane|quinone binding|sulfide oxidation, using sulfide:quinone oxidoreductase|sulfide:quinone oxidoreductase activity|hydrogen sulfide metabolic process|FAD binding" hsa00920 Sulfur metabolism SQSTM1 11179.11929 12438.14797 9920.090622 0.797553675 -0.32634648 0.199081161 1 203.4327602 159.5335359 8878 sequestosome 1 "GO:0000122,GO:0000407,GO:0000422,GO:0000423,GO:0000932,GO:0001934,GO:0002376,GO:0002931,GO:0004674,GO:0005080,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005770,GO:0005776,GO:0005783,GO:0005829,GO:0006468,GO:0006511,GO:0006914,GO:0006915,GO:0007032,GO:0008104,GO:0008270,GO:0010821,GO:0016197,GO:0016234,GO:0016235,GO:0016236,GO:0016605,GO:0019899,GO:0019901,GO:0030017,GO:0030154,GO:0030971,GO:0031397,GO:0031625,GO:0035255,GO:0035556,GO:0035973,GO:0042169,GO:0042802,GO:0043065,GO:0043066,GO:0043122,GO:0043130,GO:0043231,GO:0044753,GO:0044754,GO:0044877,GO:0045944,GO:0046578,GO:0061635,GO:0061912,GO:0070062,GO:0070498,GO:0070530,GO:0097225,GO:0097413,GO:0098780,GO:1900273,GO:1903078,GO:1905719" negative regulation of transcription by RNA polymerase II|phagophore assembly site|autophagy of mitochondrion|mitophagy|P-body|positive regulation of protein phosphorylation|immune system process|response to ischemia|protein serine/threonine kinase activity|protein kinase C binding|protein binding|nucleoplasm|cytoplasm|mitochondrion|late endosome|autophagosome|endoplasmic reticulum|cytosol|protein phosphorylation|ubiquitin-dependent protein catabolic process|autophagy|apoptotic process|endosome organization|protein localization|zinc ion binding|regulation of mitochondrion organization|endosomal transport|inclusion body|aggresome|macroautophagy|PML body|enzyme binding|protein kinase binding|sarcomere|cell differentiation|receptor tyrosine kinase binding|negative regulation of protein ubiquitination|ubiquitin protein ligase binding|ionotropic glutamate receptor binding|intracellular signal transduction|aggrephagy|SH2 domain binding|identical protein binding|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|intracellular membrane-bounded organelle|amphisome|autolysosome|protein-containing complex binding|positive regulation of transcription by RNA polymerase II|regulation of Ras protein signal transduction|regulation of protein complex stability|selective autophagy|extracellular exosome|interleukin-1-mediated signaling pathway|K63-linked polyubiquitin modification-dependent protein binding|sperm midpiece|Lewy body|response to mitochondrial depolarisation|positive regulation of long-term synaptic potentiation|positive regulation of protein localization to plasma membrane|protein localization to perinuclear region of cytoplasm "hsa04137,hsa04140,hsa04217,hsa04218,hsa04380,hsa05014,hsa05022,hsa05131,hsa05418" Mitophagy - animal|Autophagy - animal|Necroptosis|Cellular senescence|Osteoclast differentiation|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Shigellosis|Fluid shear stress and atherosclerosis SRA1 591.9991855 578.4701187 605.5282523 1.046775335 0.065951836 0.808094357 1 20.81718615 21.42627551 10011 steroid receptor RNA activator 1 "GO:0002153,GO:0003677,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0005886,GO:0006357,GO:0006915,GO:0007346,GO:0015630,GO:0030154,GO:0030374,GO:0031209,GO:0031252,GO:0042981,GO:0045171,GO:0045662,GO:0045893,GO:0071391,GO:1990904" "steroid receptor RNA activator RNA binding|DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|apoptotic process|regulation of mitotic cell cycle|microtubule cytoskeleton|cell differentiation|nuclear receptor coactivator activity|SCAR complex|cell leading edge|regulation of apoptotic process|intercellular bridge|negative regulation of myoblast differentiation|positive regulation of transcription, DNA-templated|cellular response to estrogen stimulus|ribonucleoprotein complex" SRBD1 483.5030333 493.1561804 473.8498863 0.960851562 -0.057614522 0.84126869 1 5.606910729 5.297257941 55133 S1 RNA binding domain 1 "GO:0003729,GO:0003735,GO:0006139,GO:0006412" mRNA binding|structural constituent of ribosome|nucleobase-containing compound metabolic process|translation SRC 2182.81006 2423.123933 1942.496187 0.80164954 -0.318956428 0.177306668 1 28.14312748 22.18339868 6714 "SRC proto-oncogene, non-receptor tyrosine kinase" "GO:0001545,GO:0002102,GO:0002223,GO:0004672,GO:0004713,GO:0004715,GO:0005080,GO:0005102,GO:0005158,GO:0005178,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0005743,GO:0005764,GO:0005770,GO:0005829,GO:0005884,GO:0005886,GO:0005901,GO:0005925,GO:0007049,GO:0007155,GO:0007165,GO:0007169,GO:0007172,GO:0007173,GO:0007179,GO:0007186,GO:0007229,GO:0007411,GO:0008022,GO:0008283,GO:0009612,GO:0009615,GO:0010447,GO:0010632,GO:0010634,GO:0010907,GO:0010954,GO:0014068,GO:0014069,GO:0014911,GO:0016032,GO:0016236,GO:0016301,GO:0018105,GO:0018108,GO:0019899,GO:0019900,GO:0020037,GO:0022407,GO:0030054,GO:0030154,GO:0030168,GO:0030331,GO:0030900,GO:0031234,GO:0031295,GO:0031333,GO:0031625,GO:0031648,GO:0031667,GO:0031954,GO:0032148,GO:0032211,GO:0032587,GO:0032869,GO:0033146,GO:0033625,GO:0034332,GO:0034446,GO:0035306,GO:0035556,GO:0035635,GO:0036035,GO:0036120,GO:0038083,GO:0038096,GO:0038128,GO:0042127,GO:0042169,GO:0042476,GO:0042493,GO:0043005,GO:0043065,GO:0043066,GO:0043114,GO:0043149,GO:0043154,GO:0043393,GO:0043406,GO:0043552,GO:0044325,GO:0045056,GO:0045087,GO:0045121,GO:0045124,GO:0045296,GO:0045453,GO:0045737,GO:0045747,GO:0045892,GO:0045893,GO:0046628,GO:0046777,GO:0046875,GO:0048010,GO:0048011,GO:0048013,GO:0048041,GO:0048471,GO:0048477,GO:0050731,GO:0050847,GO:0050900,GO:0051057,GO:0051117,GO:0051219,GO:0051222,GO:0051385,GO:0051602,GO:0051895,GO:0051897,GO:0051902,GO:0051974,GO:0060065,GO:0060444,GO:0060491,GO:0060576,GO:0070062,GO:0070102,GO:0070301,GO:0070374,GO:0070555,GO:0070700,GO:0070851,GO:0071222,GO:0071253,GO:0071375,GO:0071393,GO:0071398,GO:0071456,GO:0071498,GO:0071803,GO:0071902,GO:0086098,GO:0090263,GO:0097110,GO:0098609,GO:0098962,GO:0098978,GO:0099091,GO:1900182,GO:1903997,GO:2000386,GO:2000394,GO:2000573,GO:2000588,GO:2000641,GO:2000811,GO:2001237,GO:2001243,GO:2001286" "primary ovarian follicle growth|podosome|stimulatory C-type lectin receptor signaling pathway|protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein kinase C binding|signaling receptor binding|insulin receptor binding|integrin binding|protein binding|ATP binding|nucleoplasm|cytoplasm|mitochondrion|mitochondrial inner membrane|lysosome|late endosome|cytosol|actin filament|plasma membrane|caveola|focal adhesion|cell cycle|cell adhesion|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|signal complex assembly|epidermal growth factor receptor signaling pathway|transforming growth factor beta receptor signaling pathway|G protein-coupled receptor signaling pathway|integrin-mediated signaling pathway|axon guidance|protein C-terminus binding|cell population proliferation|response to mechanical stimulus|response to virus|response to acidic pH|regulation of epithelial cell migration|positive regulation of epithelial cell migration|positive regulation of glucose metabolic process|positive regulation of protein processing|positive regulation of phosphatidylinositol 3-kinase signaling|postsynaptic density|positive regulation of smooth muscle cell migration|viral process|macroautophagy|kinase activity|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|enzyme binding|kinase binding|heme binding|regulation of cell-cell adhesion|cell junction|cell differentiation|platelet activation|estrogen receptor binding|forebrain development|extrinsic component of cytoplasmic side of plasma membrane|T cell costimulation|negative regulation of protein-containing complex assembly|ubiquitin protein ligase binding|protein destabilization|response to nutrient levels|positive regulation of protein autophosphorylation|activation of protein kinase B activity|negative regulation of telomere maintenance via telomerase|ruffle membrane|cellular response to insulin stimulus|regulation of intracellular estrogen receptor signaling pathway|positive regulation of integrin activation|adherens junction organization|substrate adhesion-dependent cell spreading|positive regulation of dephosphorylation|intracellular signal transduction|entry of bacterium into host cell|osteoclast development|cellular response to platelet-derived growth factor stimulus|peptidyl-tyrosine autophosphorylation|Fc-gamma receptor signaling pathway involved in phagocytosis|ERBB2 signaling pathway|regulation of cell population proliferation|SH2 domain binding|odontogenesis|response to drug|neuron projection|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of vascular permeability|stress fiber assembly|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of protein binding|positive regulation of MAP kinase activity|positive regulation of phosphatidylinositol 3-kinase activity|ion channel binding|transcytosis|innate immune response|membrane raft|regulation of bone resorption|cadherin binding|bone resorption|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of insulin receptor signaling pathway|protein autophosphorylation|ephrin receptor binding|vascular endothelial growth factor receptor signaling pathway|neurotrophin TRK receptor signaling pathway|ephrin receptor signaling pathway|focal adhesion assembly|perinuclear region of cytoplasm|oogenesis|positive regulation of peptidyl-tyrosine phosphorylation|progesterone receptor signaling pathway|leukocyte migration|positive regulation of small GTPase mediated signal transduction|ATPase binding|phosphoprotein binding|positive regulation of protein transport|response to mineralocorticoid|response to electrical stimulus|negative regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|negative regulation of mitochondrial depolarization|negative regulation of telomerase activity|uterus development|branching involved in mammary gland duct morphogenesis|regulation of cell projection assembly|intestinal epithelial cell development|extracellular exosome|interleukin-6-mediated signaling pathway|cellular response to hydrogen peroxide|positive regulation of ERK1 and ERK2 cascade|response to interleukin-1|BMP receptor binding|growth factor receptor binding|cellular response to lipopolysaccharide|connexin binding|cellular response to peptide hormone stimulus|cellular response to progesterone stimulus|cellular response to fatty acid|cellular response to hypoxia|cellular response to fluid shear stress|positive regulation of podosome assembly|positive regulation of protein serine/threonine kinase activity|angiotensin-activated signaling pathway involved in heart process|positive regulation of canonical Wnt signaling pathway|scaffold protein binding|cell-cell adhesion|regulation of postsynaptic neurotransmitter receptor activity|glutamatergic synapse|postsynaptic specialization, intracellular component|positive regulation of protein localization to nucleus|positive regulation of non-membrane spanning protein tyrosine kinase activity|positive regulation of ovarian follicle development|positive regulation of lamellipodium morphogenesis|positive regulation of DNA biosynthetic process|positive regulation of platelet-derived growth factor receptor-beta signaling pathway|regulation of early endosome to late endosome transport|negative regulation of anoikis|negative regulation of extrinsic apoptotic signaling pathway|negative regulation of intrinsic apoptotic signaling pathway|regulation of caveolin-mediated endocytosis" "hsa01521,hsa01522,hsa04012,hsa04015,hsa04062,hsa04137,hsa04144,hsa04360,hsa04370,hsa04510,hsa04520,hsa04530,hsa04540,hsa04611,hsa04625,hsa04727,hsa04750,hsa04810,hsa04912,hsa04915,hsa04917,hsa04919,hsa04921,hsa04926,hsa05100,hsa05120,hsa05130,hsa05131,hsa05135,hsa05152,hsa05161,hsa05163,hsa05167,hsa05168,hsa05203,hsa05205,hsa05219,hsa05418" EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|Mitophagy - animal|Endocytosis|Axon guidance|VEGF signaling pathway|Focal adhesion|Adherens junction|Tight junction|Gap junction|Platelet activation|C-type lectin receptor signaling pathway|GABAergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|GnRH signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Bacterial invasion of epithelial cells|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Yersinia infection|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Viral carcinogenesis|Proteoglycans in cancer|Bladder cancer|Fluid shear stress and atherosclerosis other SRCAP 2070.22648 2344.052478 1796.400482 0.766365301 -0.383895854 0.104611855 1 10.67022966 8.040457825 10847 Snf2 related CREBBP activator protein "GO:0000812,GO:0003677,GO:0003713,GO:0004386,GO:0004402,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005794,GO:0006357,GO:0016032,GO:0016458,GO:0016573,GO:0016604,GO:0016887,GO:0032991,GO:0042393,GO:0043044,GO:0043486,GO:0045893,GO:0048471" "Swr1 complex|DNA binding|transcription coactivator activity|helicase activity|histone acetyltransferase activity|protein binding|ATP binding|nucleus|nucleoplasm|Golgi apparatus|regulation of transcription by RNA polymerase II|viral process|gene silencing|histone acetylation|nuclear body|ATPase activity|protein-containing complex|histone binding|ATP-dependent chromatin remodeling|histone exchange|positive regulation of transcription, DNA-templated|perinuclear region of cytoplasm" SRCIN1 85.51269757 74.90979955 96.1155956 1.283084405 0.359616078 0.475687829 1 0.373800685 0.471592074 80725 SRC kinase signaling inhibitor 1 "GO:0005515,GO:0005737,GO:0005925,GO:0006887,GO:0014069,GO:0015629,GO:0019901,GO:0030234,GO:0030334,GO:0030424,GO:0030425,GO:0034446,GO:0045202,GO:0061001,GO:0061098,GO:0061099,GO:0098793" protein binding|cytoplasm|focal adhesion|exocytosis|postsynaptic density|actin cytoskeleton|protein kinase binding|enzyme regulator activity|regulation of cell migration|axon|dendrite|substrate adhesion-dependent cell spreading|synapse|regulation of dendritic spine morphogenesis|positive regulation of protein tyrosine kinase activity|negative regulation of protein tyrosine kinase activity|presynapse SRD5A1 598.0781225 599.2783964 596.8778487 0.99599427 -0.005790653 0.989670429 1 4.243384183 4.155663478 6715 steroid 5 alpha-reductase 1 "GO:0001655,GO:0001889,GO:0003865,GO:0005789,GO:0006694,GO:0006702,GO:0006710,GO:0007530,GO:0008584,GO:0009055,GO:0009267,GO:0014850,GO:0016021,GO:0016101,GO:0016491,GO:0021510,GO:0021766,GO:0021794,GO:0021854,GO:0021983,GO:0021987,GO:0022900,GO:0030154,GO:0030539,GO:0030540,GO:0032354,GO:0032869,GO:0033218,GO:0042428,GO:0042448,GO:0042493,GO:0042747,GO:0043025,GO:0043209,GO:0043627,GO:0047751,GO:0048471,GO:0060348,GO:0060416,GO:0060992,GO:0070402,GO:0070852,GO:0071320,GO:0071363,GO:0071392,GO:0071394,GO:0071549,GO:0071872" "urogenital system development|liver development|3-oxo-5-alpha-steroid 4-dehydrogenase activity|endoplasmic reticulum membrane|steroid biosynthetic process|androgen biosynthetic process|androgen catabolic process|sex determination|male gonad development|electron transfer activity|cellular response to starvation|response to muscle activity|integral component of membrane|diterpenoid metabolic process|oxidoreductase activity|spinal cord development|hippocampus development|thalamus development|hypothalamus development|pituitary gland development|cerebral cortex development|electron transport chain|cell differentiation|male genitalia development|female genitalia development|response to follicle-stimulating hormone|cellular response to insulin stimulus|amide binding|serotonin metabolic process|progesterone metabolic process|response to drug|circadian sleep/wake cycle, REM sleep|neuronal cell body|myelin sheath|response to estrogen|cholestenone 5-alpha-reductase activity|perinuclear region of cytoplasm|bone development|response to growth hormone|response to fungicide|NADPH binding|cell body fiber|cellular response to cAMP|cellular response to growth factor stimulus|cellular response to estradiol stimulus|cellular response to testosterone stimulus|cellular response to dexamethasone stimulus|cellular response to epinephrine stimulus" hsa00140 Steroid hormone biosynthesis SRD5A3 153.6057011 146.6983575 160.5130447 1.094170701 0.12983783 0.759806632 1 3.084720929 3.318731672 79644 steroid 5 alpha-reductase 3 "GO:0003865,GO:0005783,GO:0005789,GO:0006488,GO:0006489,GO:0006702,GO:0016021,GO:0016095,GO:0016628,GO:0019348,GO:0019408,GO:0047751,GO:0055114,GO:0102389" "3-oxo-5-alpha-steroid 4-dehydrogenase activity|endoplasmic reticulum|endoplasmic reticulum membrane|dolichol-linked oligosaccharide biosynthetic process|dolichyl diphosphate biosynthetic process|androgen biosynthetic process|integral component of membrane|polyprenol catabolic process|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor|dolichol metabolic process|dolichol biosynthetic process|cholestenone 5-alpha-reductase activity|oxidation-reduction process|polyprenol reductase activity" "hsa00140,hsa00510" Steroid hormone biosynthesis|N-Glycan biosynthesis SREBF1 446.1959742 548.2981162 344.0938322 0.627567052 -0.672158484 0.016763806 0.768814547 5.749982851 3.548116429 6720 sterol regulatory element binding transcription factor 1 "GO:0000122,GO:0000139,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0003062,GO:0003677,GO:0003682,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005789,GO:0005829,GO:0006357,GO:0006629,GO:0007568,GO:0007623,GO:0008203,GO:0008286,GO:0008610,GO:0009267,GO:0009749,GO:0010867,GO:0010876,GO:0010883,GO:0012507,GO:0016021,GO:0019217,GO:0019901,GO:0030324,GO:0030522,GO:0031065,GO:0031647,GO:0032094,GO:0032526,GO:0032570,GO:0032810,GO:0032933,GO:0032991,GO:0033762,GO:0042493,GO:0042789,GO:0044877,GO:0045444,GO:0045471,GO:0045540,GO:0045542,GO:0045944,GO:0046676,GO:0046983,GO:0051591,GO:0071398,GO:1903146,GO:1903214,GO:1990837" "negative regulation of transcription by RNA polymerase II|Golgi membrane|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|regulation of heart rate by chemical signal|DNA binding|chromatin binding|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|endoplasmic reticulum membrane|cytosol|regulation of transcription by RNA polymerase II|lipid metabolic process|aging|circadian rhythm|cholesterol metabolic process|insulin receptor signaling pathway|lipid biosynthetic process|cellular response to starvation|response to glucose|positive regulation of triglyceride biosynthetic process|lipid localization|regulation of lipid storage|ER to Golgi transport vesicle membrane|integral component of membrane|regulation of fatty acid metabolic process|protein kinase binding|lung development|intracellular receptor signaling pathway|positive regulation of histone deacetylation|regulation of protein stability|response to food|response to retinoic acid|response to progesterone|sterol response element binding|SREBP signaling pathway|protein-containing complex|response to glucagon|response to drug|mRNA transcription by RNA polymerase II|protein-containing complex binding|fat cell differentiation|response to ethanol|regulation of cholesterol biosynthetic process|positive regulation of cholesterol biosynthetic process|positive regulation of transcription by RNA polymerase II|negative regulation of insulin secretion|protein dimerization activity|response to cAMP|cellular response to fatty acid|regulation of autophagy of mitochondrion|regulation of protein targeting to mitochondrion|sequence-specific double-stranded DNA binding" "hsa04152,hsa04910,hsa04931,hsa04932" AMPK signaling pathway|Insulin signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease bHLH SREBF2 2820.513843 2977.664532 2663.363154 0.894447016 -0.160932071 0.496703259 1 21.76287091 19.14000222 6721 sterol regulatory element binding transcription factor 2 "GO:0000122,GO:0000139,GO:0000247,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0006357,GO:0006629,GO:0008022,GO:0008203,GO:0008593,GO:0009267,GO:0010886,GO:0012507,GO:0032933,GO:0032937,GO:0042632,GO:0043231,GO:0045540,GO:0045944,GO:0046983,GO:0070888,GO:0071404,GO:0071499,GO:0090370,GO:1902895,GO:1903146,GO:1903955,GO:1990837" "negative regulation of transcription by RNA polymerase II|Golgi membrane|C-8 sterol isomerase activity|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|regulation of transcription by RNA polymerase II|lipid metabolic process|protein C-terminus binding|cholesterol metabolic process|regulation of Notch signaling pathway|cellular response to starvation|positive regulation of cholesterol storage|ER to Golgi transport vesicle membrane|SREBP signaling pathway|SREBP-SCAP-Insig complex|cholesterol homeostasis|intracellular membrane-bounded organelle|regulation of cholesterol biosynthetic process|positive regulation of transcription by RNA polymerase II|protein dimerization activity|E-box binding|cellular response to low-density lipoprotein particle stimulus|cellular response to laminar fluid shear stress|negative regulation of cholesterol efflux|positive regulation of pri-miRNA transcription by RNA polymerase II|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion|sequence-specific double-stranded DNA binding" bHLH SREK1 1152.6759 1268.264523 1037.087277 0.817721585 -0.290318371 0.232048437 1 8.488204993 6.824840404 140890 splicing regulatory glutamic acid and lysine rich protein 1 "GO:0003723,GO:0005515,GO:0005654,GO:0005681,GO:0006397,GO:0008380,GO:0016607" RNA binding|protein binding|nucleoplasm|spliceosomal complex|mRNA processing|RNA splicing|nuclear speck SREK1IP1 706.4704791 644.0161934 768.9247648 1.193952532 0.255745481 0.318354038 1 4.891824735 5.742871889 285672 SREK1 interacting protein 1 "GO:0003676,GO:0005515,GO:0006397,GO:0008270,GO:0008380" nucleic acid binding|protein binding|mRNA processing|zinc ion binding|RNA splicing SRF 764.8330361 712.6835096 816.9825626 1.146346943 0.197043743 0.437723343 1 8.872080488 10.0002931 6722 serum response factor "GO:0000978,GO:0000981,GO:0001228,GO:0001569,GO:0001666,GO:0001707,GO:0001764,GO:0001829,GO:0001947,GO:0002011,GO:0002042,GO:0003257,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007160,GO:0007507,GO:0007616,GO:0008134,GO:0008285,GO:0008306,GO:0009636,GO:0009725,GO:0010669,GO:0010735,GO:0010736,GO:0021766,GO:0022028,GO:0030036,GO:0030155,GO:0030168,GO:0030220,GO:0030336,GO:0030878,GO:0031175,GO:0031490,GO:0033561,GO:0034097,GO:0035855,GO:0035912,GO:0042803,GO:0042826,GO:0043149,GO:0043589,GO:0045059,GO:0045214,GO:0045597,GO:0045773,GO:0045944,GO:0045987,GO:0046016,GO:0046716,GO:0048538,GO:0048589,GO:0048666,GO:0048821,GO:0051091,GO:0051150,GO:0051491,GO:0055003,GO:0060055,GO:0060218,GO:0060261,GO:0060292,GO:0060324,GO:0060347,GO:0060425,GO:0060532,GO:0060534,GO:0060947,GO:0061029,GO:0061145,GO:0061629,GO:0070830,GO:0070878,GO:0071333,GO:0090009,GO:0090136,GO:0090398,GO:1900222,GO:1902894,GO:1902895,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|branching involved in blood vessel morphogenesis|response to hypoxia|mesoderm formation|neuron migration|trophectodermal cell differentiation|heart looping|morphogenesis of an epithelial sheet|cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|cell-matrix adhesion|heart development|long-term memory|transcription factor binding|negative regulation of cell population proliferation|associative learning|response to toxic substance|response to hormone|epithelial structure maintenance|positive regulation of transcription via serum response element binding|serum response element binding|hippocampus development|tangential migration from the subventricular zone to the olfactory bulb|actin cytoskeleton organization|regulation of cell adhesion|platelet activation|platelet formation|negative regulation of cell migration|thyroid gland development|neuron projection development|chromatin DNA binding|regulation of water loss via skin|response to cytokine|megakaryocyte development|dorsal aorta morphogenesis|protein homodimerization activity|histone deacetylase binding|stress fiber assembly|skin morphogenesis|positive thymic T cell selection|sarcomere organization|positive regulation of cell differentiation|positive regulation of axon extension|positive regulation of transcription by RNA polymerase II|positive regulation of smooth muscle contraction|positive regulation of transcription by glucose|muscle cell cellular homeostasis|thymus development|developmental growth|neuron development|erythrocyte development|positive regulation of DNA-binding transcription factor activity|regulation of smooth muscle cell differentiation|positive regulation of filopodium assembly|cardiac myofibril assembly|angiogenesis involved in wound healing|hematopoietic stem cell differentiation|positive regulation of transcription initiation from RNA polymerase II promoter|long-term synaptic depression|face development|heart trabecula formation|lung morphogenesis|bronchus cartilage development|trachea cartilage development|cardiac vascular smooth muscle cell differentiation|eyelid development in camera-type eye|lung smooth muscle development|RNA polymerase II-specific DNA-binding transcription factor binding|bicellular tight junction assembly|primary miRNA binding|cellular response to glucose stimulus|primitive streak formation|epithelial cell-cell adhesion|cellular senescence|negative regulation of amyloid-beta clearance|negative regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of pri-miRNA transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" "hsa04010,hsa04022,hsa05166,hsa05203" MAPK signaling pathway|cGMP-PKG signaling pathway|Human T-cell leukemia virus 1 infection|Viral carcinogenesis SRF SRFBP1 369.5223786 402.6401726 336.4045846 0.835496822 -0.259293754 0.382439869 1 6.789309949 5.577526169 153443 serum response factor binding protein 1 "GO:0003723,GO:0005634,GO:0030490,GO:0030686,GO:0048471" RNA binding|nucleus|maturation of SSU-rRNA|90S preribosome|perinuclear region of cytoplasm SRGAP1 1623.020274 1718.763734 1527.276814 0.888590319 -0.170409672 0.474408732 1 8.245147104 7.203957868 57522 SLIT-ROBO Rho GTPase activating protein 1 "GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0007165,GO:0030336,GO:0043547,GO:0051056" GTPase activator activity|protein binding|cytoplasm|cytosol|signal transduction|negative regulation of cell migration|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction hsa04360 Axon guidance SRGAP2 1833.580782 2048.574935 1618.58663 0.790103697 -0.339886083 0.151506613 1 11.40979745 8.864070617 23380 SLIT-ROBO Rho GTPase activating protein 2 "GO:0003363,GO:0005096,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0014069,GO:0021816,GO:0030027,GO:0030336,GO:0031267,GO:0034446,GO:0042802,GO:0042803,GO:0043547,GO:0044327,GO:0045211,GO:0045335,GO:0046847,GO:0048812,GO:0051014,GO:0051056,GO:0060548,GO:0060996,GO:2001223" lamellipodium assembly involved in ameboidal cell migration|GTPase activator activity|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|signal transduction|postsynaptic density|extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration|lamellipodium|negative regulation of cell migration|small GTPase binding|substrate adhesion-dependent cell spreading|identical protein binding|protein homodimerization activity|positive regulation of GTPase activity|dendritic spine head|postsynaptic membrane|phagocytic vesicle|filopodium assembly|neuron projection morphogenesis|actin filament severing|regulation of small GTPase mediated signal transduction|negative regulation of cell death|dendritic spine development|negative regulation of neuron migration hsa04360 Axon guidance SRGAP2B 242.115723 237.2143652 247.0170807 1.041324291 0.058419425 0.875074376 1 1.184809985 1.213125924 647135 SLIT-ROBO Rho GTPase activating protein 2B "GO:0005737,GO:0007399,GO:0030336" cytoplasm|nervous system development|negative regulation of cell migration SRGAP2C 512.4119395 507.7219747 517.1019043 1.018474539 0.026409915 0.930206551 1 3.821208382 3.826679387 653464 SLIT-ROBO Rho GTPase activating protein 2C "GO:0005737,GO:0021816,GO:0030336,GO:0042803,GO:0046982,GO:0051490,GO:0061000,GO:2001224" cytoplasm|extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration|negative regulation of cell migration|protein homodimerization activity|protein heterodimerization activity|negative regulation of filopodium assembly|negative regulation of dendritic spine development|positive regulation of neuron migration SRGAP3 4.003139677 4.161655531 3.844623824 0.923820772 -0.11431511 1 1 0.015677272 0.014240636 9901 SLIT-ROBO Rho GTPase activating protein 3 "GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0007165,GO:0030336,GO:0043547,GO:0051056" GTPase activator activity|protein binding|cytoplasm|cytosol|signal transduction|negative regulation of cell migration|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction hsa04360 Axon guidance SRGN 13355.02143 11033.58923 15676.45364 1.420793662 0.506697051 0.05079713 1 211.4335289 295.3765735 5552 serglycin "GO:0001818,GO:0002576,GO:0005515,GO:0005576,GO:0005615,GO:0005794,GO:0006915,GO:0016485,GO:0030141,GO:0030502,GO:0031093,GO:0031214,GO:0033363,GO:0033364,GO:0033371,GO:0033373,GO:0033382,GO:0042629,GO:0050804,GO:0098685,GO:0098978,GO:0099091,GO:0099175,GO:0140507" "negative regulation of cytokine production|platelet degranulation|protein binding|extracellular region|extracellular space|Golgi apparatus|apoptotic process|protein processing|secretory granule|negative regulation of bone mineralization|platelet alpha granule lumen|biomineral tissue development|secretory granule organization|mast cell secretory granule organization|T cell secretory granule organization|maintenance of protease location in mast cell secretory granule|maintenance of granzyme B location in T cell secretory granule|mast cell granule|modulation of chemical synaptic transmission|Schaffer collateral - CA1 synapse|glutamatergic synapse|postsynaptic specialization, intracellular component|regulation of postsynapse organization|granzyme-mediated programmed cell death signaling pathway" SRI 2522.451586 2142.212184 2902.690987 1.354996955 0.43828961 0.063918239 1 48.60796219 64.76150193 6717 sorcin "GO:0001508,GO:0002020,GO:0005102,GO:0005246,GO:0005509,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005789,GO:0005790,GO:0005829,GO:0006816,GO:0006880,GO:0006942,GO:0007165,GO:0007507,GO:0007517,GO:0008016,GO:0010459,GO:0010649,GO:0010880,GO:0016020,GO:0016529,GO:0030018,GO:0030315,GO:0033017,GO:0035774,GO:0042584,GO:0042994,GO:0043679,GO:0044325,GO:0044326,GO:0046982,GO:0051281,GO:0051924,GO:0055118,GO:0060315,GO:0070062,GO:0070491,GO:0086004,GO:1901077,GO:1901841,GO:1901844,GO:2000678" action potential|protease binding|signaling receptor binding|calcium channel regulator activity|calcium ion binding|protein binding|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum membrane|smooth endoplasmic reticulum|cytosol|calcium ion transport|intracellular sequestering of iron ion|regulation of striated muscle contraction|signal transduction|heart development|muscle organ development|regulation of heart contraction|negative regulation of heart rate|regulation of cell communication by electrical coupling|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|membrane|sarcoplasmic reticulum|Z disc|T-tubule|sarcoplasmic reticulum membrane|positive regulation of insulin secretion involved in cellular response to glucose stimulus|chromaffin granule membrane|cytoplasmic sequestering of transcription factor|axon terminus|ion channel binding|dendritic spine neck|protein heterodimerization activity|positive regulation of release of sequestered calcium ion into cytosol|regulation of calcium ion transport|negative regulation of cardiac muscle contraction|negative regulation of ryanodine-sensitive calcium-release channel activity|extracellular exosome|repressing transcription factor binding|regulation of cardiac muscle cell contraction|regulation of relaxation of muscle|regulation of high voltage-gated calcium channel activity|regulation of cell communication by electrical coupling involved in cardiac conduction|negative regulation of transcription regulatory region DNA binding SRM 866.3035722 840.6544172 891.9527272 1.061021876 0.085454402 0.735287899 1 30.23192802 31.53997625 6723 spermidine synthase "GO:0004766,GO:0005515,GO:0005829,GO:0006595,GO:0006596,GO:0008295,GO:0042802,GO:0042803,GO:1990830" spermidine synthase activity|protein binding|cytosol|polyamine metabolic process|polyamine biosynthetic process|spermidine biosynthetic process|identical protein binding|protein homodimerization activity|cellular response to leukemia inhibitory factor "hsa00270,hsa00330,hsa00480" Cysteine and methionine metabolism|Arginine and proline metabolism|Glutathione metabolism SRMS 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.02720479 0.037067692 6725 src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites "GO:0004713,GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0007169,GO:0009968,GO:0018108,GO:0030154,GO:0031234,GO:0038083,GO:0042127,GO:0045087" protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|protein binding|ATP binding|cytoplasm|cytosol|transmembrane receptor protein tyrosine kinase signaling pathway|negative regulation of signal transduction|peptidyl-tyrosine phosphorylation|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|peptidyl-tyrosine autophosphorylation|regulation of cell population proliferation|innate immune response SRP14 2077.775375 1797.835189 2357.71556 1.311419186 0.391128906 0.098303511 1 82.78443466 106.748406 6727 signal recognition particle 14 "GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005786,GO:0005829,GO:0006613,GO:0006614,GO:0008312,GO:0030942,GO:0034774,GO:0043312,GO:0045047,GO:1904813" "RNA binding|protein binding|extracellular region|nucleus|cytoplasm|signal recognition particle, endoplasmic reticulum targeting|cytosol|cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane|7S RNA binding|endoplasmic reticulum signal peptide binding|secretory granule lumen|neutrophil degranulation|protein targeting to ER|ficolin-1-rich granule lumen" hsa03060 Protein export SRP19 624.1186521 576.389291 671.8480132 1.165615017 0.221091369 0.39860607 1 3.21194916 3.681247142 6728 signal recognition particle 19 "GO:0003723,GO:0005515,GO:0005730,GO:0005786,GO:0005829,GO:0006613,GO:0006614,GO:0006617,GO:0008312,GO:0043022,GO:0048500" "RNA binding|protein binding|nucleolus|signal recognition particle, endoplasmic reticulum targeting|cytosol|cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|7S RNA binding|ribosome binding|signal recognition particle" hsa03060 Protein export SRP54 1943.912385 1753.097392 2134.727378 1.217688982 0.284145692 0.23010936 1 39.03195068 46.73344656 6729 signal recognition particle 54 "GO:0003723,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005730,GO:0005737,GO:0005783,GO:0005786,GO:0005829,GO:0006614,GO:0006616,GO:0006617,GO:0008312,GO:0016607,GO:0019003,GO:0030593,GO:0030851,GO:0030942,GO:0031017,GO:0043021,GO:0045047" "RNA binding|GTPase activity|protein binding|GTP binding|nucleus|nucleolus|cytoplasm|endoplasmic reticulum|signal recognition particle, endoplasmic reticulum targeting|cytosol|SRP-dependent cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane, translocation|SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|7S RNA binding|nuclear speck|GDP binding|neutrophil chemotaxis|granulocyte differentiation|endoplasmic reticulum signal peptide binding|exocrine pancreas development|ribonucleoprotein complex binding|protein targeting to ER" hsa03060 Protein export SRP68 2485.267215 2389.830688 2580.703742 1.07986886 0.110856122 0.639968403 1 41.96803933 44.56161033 6730 signal recognition particle 68 "GO:0003723,GO:0005047,GO:0005515,GO:0005730,GO:0005783,GO:0005786,GO:0005829,GO:0005840,GO:0005925,GO:0006614,GO:0008312,GO:0019904,GO:0030942,GO:0042493,GO:0043022,GO:0048500" "RNA binding|signal recognition particle binding|protein binding|nucleolus|endoplasmic reticulum|signal recognition particle, endoplasmic reticulum targeting|cytosol|ribosome|focal adhesion|SRP-dependent cotranslational protein targeting to membrane|7S RNA binding|protein domain specific binding|endoplasmic reticulum signal peptide binding|response to drug|ribosome binding|signal recognition particle" hsa03060 Protein export SRP72 2881.883785 3036.968123 2726.799447 0.897868972 -0.15542317 0.511673553 1 37.91284375 33.47113993 6731 signal recognition particle 72 "GO:0003723,GO:0005047,GO:0005515,GO:0005783,GO:0005786,GO:0005829,GO:0006614,GO:0008312,GO:0030911,GO:0043022,GO:0048500" "RNA binding|signal recognition particle binding|protein binding|endoplasmic reticulum|signal recognition particle, endoplasmic reticulum targeting|cytosol|SRP-dependent cotranslational protein targeting to membrane|7S RNA binding|TPR domain binding|ribosome binding|signal recognition particle" hsa03060 Protein export SRP9 4976.634718 4548.689495 5404.579941 1.188161985 0.248731536 0.300096061 1 151.2493447 176.7015396 6726 signal recognition particle 9 "GO:0003723,GO:0005047,GO:0005515,GO:0005785,GO:0005786,GO:0005829,GO:0006614,GO:0008312,GO:0045900" "RNA binding|signal recognition particle binding|protein binding|signal recognition particle receptor complex|signal recognition particle, endoplasmic reticulum targeting|cytosol|SRP-dependent cotranslational protein targeting to membrane|7S RNA binding|negative regulation of translational elongation" hsa03060 Protein export SRPK1 3120.551788 3183.666481 3057.437096 0.96035094 -0.058366391 0.806422629 1 39.07691554 36.89957978 6732 SRSF protein kinase 1 "GO:0000165,GO:0000245,GO:0000287,GO:0000785,GO:0003723,GO:0004672,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0006468,GO:0007059,GO:0008380,GO:0010468,GO:0016032,GO:0016363,GO:0016607,GO:0035092,GO:0035556,GO:0045070,GO:0045071,GO:0045087,GO:0048024,GO:0050684,GO:0106310,GO:0106311" "MAPK cascade|spliceosomal complex assembly|magnesium ion binding|chromatin|RNA binding|protein kinase activity|protein serine/threonine kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|protein phosphorylation|chromosome segregation|RNA splicing|regulation of gene expression|viral process|nuclear matrix|nuclear speck|sperm chromatin condensation|intracellular signal transduction|positive regulation of viral genome replication|negative regulation of viral genome replication|innate immune response|regulation of mRNA splicing, via spliceosome|regulation of mRNA processing|protein serine kinase activity|protein threonine kinase activity" hsa05168 Herpes simplex virus 1 infection SRPK2 1135.930512 1181.910171 1089.950854 0.922194327 -0.116857304 0.632852189 1 8.627598625 7.823184223 6733 SRSF protein kinase 2 "GO:0000165,GO:0000245,GO:0000287,GO:0000785,GO:0001525,GO:0003723,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006468,GO:0008284,GO:0008380,GO:0010468,GO:0010628,GO:0016607,GO:0018105,GO:0030154,GO:0035063,GO:0035556,GO:0043525,GO:0045070,GO:0045071,GO:0045087,GO:0045787,GO:0048024,GO:0050684,GO:0062176,GO:0071889,GO:0106310,GO:0106311" "MAPK cascade|spliceosomal complex assembly|magnesium ion binding|chromatin|angiogenesis|RNA binding|protein serine/threonine kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|protein phosphorylation|positive regulation of cell population proliferation|RNA splicing|regulation of gene expression|positive regulation of gene expression|nuclear speck|peptidyl-serine phosphorylation|cell differentiation|nuclear speck organization|intracellular signal transduction|positive regulation of neuron apoptotic process|positive regulation of viral genome replication|negative regulation of viral genome replication|innate immune response|positive regulation of cell cycle|regulation of mRNA splicing, via spliceosome|regulation of mRNA processing|R-loop disassembly|14-3-3 protein binding|protein serine kinase activity|protein threonine kinase activity" SRPRA 3240.121356 3219.040553 3261.202159 1.013097569 0.018773123 0.938226725 1 35.78301978 35.64506741 6734 SRP receptor subunit alpha "GO:0003723,GO:0003924,GO:0005047,GO:0005525,GO:0005785,GO:0005789,GO:0006605,GO:0006613,GO:0006614,GO:0016020,GO:0036498,GO:0045047,GO:0070062" RNA binding|GTPase activity|signal recognition particle binding|GTP binding|signal recognition particle receptor complex|endoplasmic reticulum membrane|protein targeting|cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane|membrane|IRE1-mediated unfolded protein response|protein targeting to ER|extracellular exosome hsa03060 Protein export SRPRB 493.0598727 529.5706663 456.5490791 0.862111722 -0.214053253 0.437112124 1 9.96200675 8.444648175 58477 SRP receptor subunit beta "GO:0005525,GO:0005737,GO:0005785,GO:0005789,GO:0005881,GO:0016020,GO:0016021,GO:0036498,GO:0045047" GTP binding|cytoplasm|signal recognition particle receptor complex|endoplasmic reticulum membrane|cytoplasmic microtubule|membrane|integral component of membrane|IRE1-mediated unfolded protein response|protein targeting to ER hsa03060 Protein export SRPX 841.377684 880.1901447 802.5652233 0.911808918 -0.133196576 0.596833243 1 24.1885326 21.68625382 8406 sushi repeat containing protein X-linked "GO:0001845,GO:0005201,GO:0005515,GO:0005776,GO:0005783,GO:0006914,GO:0007155,GO:0009986,GO:0016020,GO:0034976,GO:0060244,GO:0062023,GO:2001241" phagolysosome assembly|extracellular matrix structural constituent|protein binding|autophagosome|endoplasmic reticulum|autophagy|cell adhesion|cell surface|membrane|response to endoplasmic reticulum stress|negative regulation of cell proliferation involved in contact inhibition|collagen-containing extracellular matrix|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand SRPX2 285.0406484 253.8609874 316.2203095 1.245643582 0.316891326 0.325394347 1 2.038533602 2.49679478 27286 sushi repeat containing protein X-linked 2 "GO:0001525,GO:0005102,GO:0005201,GO:0005515,GO:0005615,GO:0005737,GO:0009986,GO:0036458,GO:0042325,GO:0042802,GO:0048870,GO:0051965,GO:0060076,GO:0062023,GO:0071625,GO:0090050,GO:0097060,GO:0098609" angiogenesis|signaling receptor binding|extracellular matrix structural constituent|protein binding|extracellular space|cytoplasm|cell surface|hepatocyte growth factor binding|regulation of phosphorylation|identical protein binding|cell motility|positive regulation of synapse assembly|excitatory synapse|collagen-containing extracellular matrix|vocalization behavior|positive regulation of cell migration involved in sprouting angiogenesis|synaptic membrane|cell-cell adhesion SRR 504.6484644 493.1561804 516.1407484 1.046607077 0.065719919 0.816062633 1 5.652671599 5.81712774 63826 serine racemase "GO:0000287,GO:0003941,GO:0005509,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006563,GO:0006564,GO:0007420,GO:0007568,GO:0008721,GO:0009069,GO:0016594,GO:0018114,GO:0030165,GO:0030170,GO:0030378,GO:0032496,GO:0042493,GO:0042802,GO:0042803,GO:0042866,GO:0043025,GO:0043278,GO:0045177,GO:0070178,GO:0070179" magnesium ion binding|L-serine ammonia-lyase activity|calcium ion binding|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|L-serine metabolic process|L-serine biosynthetic process|brain development|aging|D-serine ammonia-lyase activity|serine family amino acid metabolic process|glycine binding|threonine racemase activity|PDZ domain binding|pyridoxal phosphate binding|serine racemase activity|response to lipopolysaccharide|response to drug|identical protein binding|protein homodimerization activity|pyruvate biosynthetic process|neuronal cell body|response to morphine|apical part of cell|D-serine metabolic process|D-serine biosynthetic process hsa00260 "Glycine, serine and threonine metabolism" SRRD 325.6016986 372.46817 278.7352272 0.748346435 -0.418221797 0.172854384 1 14.65924902 10.78662536 402055 SRR1 domain containing "GO:0005634,GO:0005737,GO:0006783,GO:0007017,GO:0007623,GO:0042752,GO:0070453" nucleus|cytoplasm|heme biosynthetic process|microtubule-based process|circadian rhythm|regulation of circadian rhythm|regulation of heme biosynthetic process SRRM1 1831.932072 1866.502505 1797.361638 0.962956992 -0.05445673 0.82021842 1 17.06558304 16.15843144 10250 serine and arginine repetitive matrix 1 "GO:0000375,GO:0000398,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006405,GO:0006406,GO:0008380,GO:0016363,GO:0016607,GO:0031124,GO:0071013" "RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|RNA splicing|nuclear matrix|nuclear speck|mRNA 3'-end processing|catalytic step 2 spliceosome" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway SRRM2 9066.893832 10164.84363 7968.944031 0.783971138 -0.351127553 0.159000356 1 46.42127525 35.78395342 23524 serine/arginine repetitive matrix 2 "GO:0000398,GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0015030,GO:0016607,GO:0047485,GO:0070742,GO:0071005,GO:0071007,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|nucleoplasm|Cajal body|nuclear speck|protein N-terminus binding|C2H2 zinc finger domain binding|U2-type precatalytic spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome" SRRM3 136.5231603 101.9605605 171.0857602 1.677960177 0.746708477 0.075648576 1 1.472253171 2.429043691 222183 serine/arginine repetitive matrix 3 GO:0003729 mRNA binding SRRM5 5.524131538 6.242483296 4.80577978 0.769850643 -0.377349516 0.927604977 1 0.138179121 0.104597205 100170229 serine/arginine repetitive matrix 5 SRRT 1351.499976 1504.438474 1198.561477 0.796683612 -0.327921197 0.171854652 1 22.12430872 17.33112569 51593 "serrate, RNA effector molecule" "GO:0000398,GO:0003677,GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0006355,GO:0016604,GO:0031053,GO:0032991,GO:0042795,GO:0046685,GO:0050769,GO:0097150" "mRNA splicing, via spliceosome|DNA binding|RNA binding|protein binding|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|nuclear body|primary miRNA processing|protein-containing complex|snRNA transcription by RNA polymerase II|response to arsenic-containing substance|positive regulation of neurogenesis|neuronal stem cell population maintenance" SRSF1 3672.668032 3749.651633 3595.684431 0.958938265 -0.060490155 0.799916112 1 36.10175286 34.04004427 6426 serine and arginine rich splicing factor 1 "GO:0000380,GO:0000395,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006376,GO:0006397,GO:0006405,GO:0006406,GO:0016607,GO:0031124,GO:0035145,GO:0044547,GO:0071013" "alternative mRNA splicing, via spliceosome|mRNA 5'-splice site recognition|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|mRNA splice site selection|mRNA processing|RNA export from nucleus|mRNA export from nucleus|nuclear speck|mRNA 3'-end processing|exon-exon junction complex|DNA topoisomerase binding|catalytic step 2 spliceosome" "hsa03040,hsa04657,hsa05168" Spliceosome|IL-17 signaling pathway|Herpes simplex virus 1 infection SRSF10 2322.604146 2358.618272 2286.590019 0.969461674 -0.044744229 0.851482289 1 11.49019829 10.95290565 10772 serine and arginine rich splicing factor 10 "GO:0000244,GO:0000375,GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006376,GO:0016482,GO:0016607,GO:0048024,GO:0048025,GO:0050733,GO:0051082" "spliceosomal tri-snRNP complex assembly|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|mRNA splice site selection|cytosolic transport|nuclear speck|regulation of mRNA splicing, via spliceosome|negative regulation of mRNA splicing, via spliceosome|RS domain binding|unfolded protein binding" hsa03040 Spliceosome SRSF11 4522.706181 4604.871845 4440.540517 0.964313594 -0.052425709 0.827176354 1 36.28965549 34.40902072 9295 serine and arginine rich splicing factor 11 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006397,GO:0006405,GO:0006406,GO:0008380,GO:0016607,GO:0031124" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|mRNA processing|RNA export from nucleus|mRNA export from nucleus|RNA splicing|nuclear speck|mRNA 3'-end processing" SRSF2 2889.871786 2792.470861 2987.272711 1.069759672 0.097286722 0.681809005 1 78.93487156 83.02833077 6427 serine and arginine rich splicing factor 2 "GO:0000398,GO:0003714,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006397,GO:0006405,GO:0006406,GO:0008380,GO:0016605,GO:0016607,GO:0031124,GO:0045892" "mRNA splicing, via spliceosome|transcription corepressor activity|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|mRNA processing|RNA export from nucleus|mRNA export from nucleus|RNA splicing|PML body|nuclear speck|mRNA 3'-end processing|negative regulation of transcription, DNA-templated" "hsa03040,hsa05168" Spliceosome|Herpes simplex virus 1 infection SRSF3 2641.443768 2616.640915 2666.246622 1.018957782 0.027094278 0.910373752 1 33.02869358 33.0916761 6428 serine and arginine rich splicing factor 3 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0006405,GO:0006406,GO:0016607,GO:0031124,GO:0043274,GO:0048024,GO:1990825,GO:1990830" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|cytoplasm|RNA export from nucleus|mRNA export from nucleus|nuclear speck|mRNA 3'-end processing|phospholipase binding|regulation of mRNA splicing, via spliceosome|sequence-specific mRNA binding|cellular response to leukemia inhibitory factor" "hsa03040,hsa05014,hsa05168" Spliceosome|Amyotrophic lateral sclerosis|Herpes simplex virus 1 infection SRSF4 1604.596608 1424.326605 1784.86661 1.253130148 0.325536259 0.171356283 1 33.07819544 40.75765286 6429 serine and arginine rich splicing factor 4 "GO:0000375,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0006397,GO:0006405,GO:0006406,GO:0008380,GO:0016607,GO:0031124,GO:0032868,GO:0048025,GO:1990825" "RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|mRNA processing|RNA export from nucleus|mRNA export from nucleus|RNA splicing|nuclear speck|mRNA 3'-end processing|response to insulin|negative regulation of mRNA splicing, via spliceosome|sequence-specific mRNA binding" "hsa03040,hsa05168" Spliceosome|Herpes simplex virus 1 infection SRSF5 4052.378126 3915.07744 4189.678812 1.070139448 0.097798804 0.681979696 1 86.48198981 90.99912695 6430 serine and arginine rich splicing factor 5 "GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006376,GO:0006397,GO:0006405,GO:0006406,GO:0016607,GO:0031124,GO:0032869,GO:0033120,GO:0043422,GO:0051726,GO:0097421" "mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleoplasm|nucleolus|cytosol|mRNA splice site selection|mRNA processing|RNA export from nucleus|mRNA export from nucleus|nuclear speck|mRNA 3'-end processing|cellular response to insulin stimulus|positive regulation of RNA splicing|protein kinase B binding|regulation of cell cycle|liver regeneration" "hsa03040,hsa05168" Spliceosome|Herpes simplex virus 1 infection SRSF6 2953.970482 3036.968123 2870.972841 0.945341776 -0.081092083 0.732818157 1 37.23349576 34.60938182 6431 serine and arginine rich splicing factor 6 "GO:0000380,GO:0000381,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0006376,GO:0006405,GO:0006406,GO:0010837,GO:0016607,GO:0031124,GO:0032868,GO:0036002,GO:0045617,GO:0048025,GO:0060501,GO:0060548,GO:0061041,GO:2000675" "alternative mRNA splicing, via spliceosome|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleoplasm|mRNA splice site selection|RNA export from nucleus|mRNA export from nucleus|regulation of keratinocyte proliferation|nuclear speck|mRNA 3'-end processing|response to insulin|pre-mRNA binding|negative regulation of keratinocyte differentiation|negative regulation of mRNA splicing, via spliceosome|positive regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of cell death|regulation of wound healing|negative regulation of type B pancreatic cell apoptotic process" "hsa03040,hsa05168" Spliceosome|Herpes simplex virus 1 infection SRSF7 2075.831712 2049.615349 2102.048076 1.02558174 0.036442481 0.879492304 1 36.71843039 37.02760025 6432 serine and arginine rich splicing factor 7 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006397,GO:0006405,GO:0006406,GO:0008270,GO:0008380,GO:0016607,GO:0019904,GO:0031124,GO:0048025,GO:0070062,GO:1990830" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|mRNA processing|RNA export from nucleus|mRNA export from nucleus|zinc ion binding|RNA splicing|nuclear speck|protein domain specific binding|mRNA 3'-end processing|negative regulation of mRNA splicing, via spliceosome|extracellular exosome|cellular response to leukemia inhibitory factor" "hsa03040,hsa05014,hsa05168" Spliceosome|Amyotrophic lateral sclerosis|Herpes simplex virus 1 infection SRSF8 444.3088752 460.90335 427.7144004 0.92799152 -0.107816473 0.707199924 1 5.711066795 5.21113622 10929 serine and arginine rich splicing factor 8 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0016607" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|cytoplasm|cytosol|nuclear speck" "hsa03040,hsa05168" Spliceosome|Herpes simplex virus 1 infection SRSF9 2986.656658 2721.722717 3251.590599 1.194681067 0.256625526 0.278418614 1 126.087968 148.1142369 8683 serine and arginine rich splicing factor 9 "GO:0000380,GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006376,GO:0006397,GO:0006405,GO:0006406,GO:0009636,GO:0016607,GO:0019904,GO:0031124,GO:0043279,GO:0048025" "alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|nucleolus|mRNA splice site selection|mRNA processing|RNA export from nucleus|mRNA export from nucleus|response to toxic substance|nuclear speck|protein domain specific binding|mRNA 3'-end processing|response to alkaloid|negative regulation of mRNA splicing, via spliceosome" "hsa03040,hsa05168" Spliceosome|Herpes simplex virus 1 infection SRXN1 1825.57193 1649.056004 2002.087856 1.214081178 0.279864889 0.237798279 1 34.81293042 41.55846394 140809 sulfiredoxin 1 "GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006979,GO:0016667,GO:0032542,GO:0034599,GO:0055114,GO:0098869" "protein binding|ATP binding|cytoplasm|cytosol|response to oxidative stress|oxidoreductase activity, acting on a sulfur group of donors|sulfiredoxin activity|cellular response to oxidative stress|oxidation-reduction process|cellular oxidant detoxification" SS18 2559.230336 2603.115534 2515.345137 0.966282558 -0.049482975 0.835620157 1 33.74386489 32.06048901 6760 SS18 subunit of BAF chromatin remodeling complex "GO:0000226,GO:0000902,GO:0005515,GO:0005634,GO:0015630,GO:0016514,GO:0030374,GO:0035556,GO:0042493,GO:0045944,GO:0048013,GO:0071564,GO:0097150" microtubule cytoskeleton organization|cell morphogenesis|protein binding|nucleus|microtubule cytoskeleton|SWI/SNF complex|nuclear receptor coactivator activity|intracellular signal transduction|response to drug|positive regulation of transcription by RNA polymerase II|ephrin receptor signaling pathway|npBAF complex|neuronal stem cell population maintenance hsa05202 Transcriptional misregulation in cancer SS18L1 668.707994 636.7332962 700.6826919 1.100433566 0.138072052 0.595713696 1 5.115352364 5.534909988 26039 SS18L1 subunit of BAF chromatin remodeling complex "GO:0000776,GO:0000777,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006325,GO:0016358,GO:0016604,GO:0045893,GO:0045944,GO:0050775,GO:0071565" "kinetochore|condensed chromosome kinetochore|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytosol|chromatin organization|dendrite development|nuclear body|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of dendrite morphogenesis|nBAF complex" SS18L2 309.9514454 251.7801596 368.1227311 1.462079982 0.548022235 0.078553407 1 4.686796081 6.737803912 51188 SS18 like 2 "GO:0003713,GO:0005515,GO:0005634,GO:0045944,GO:0050775" transcription coactivator activity|protein binding|nucleus|positive regulation of transcription by RNA polymerase II|positive regulation of dendrite morphogenesis SSB 1818.328048 1736.45077 1900.205325 1.094304174 0.130013806 0.584404658 1 49.68964404 53.46568309 6741 small RNA binding exonuclease protection factor La "GO:0000049,GO:0000781,GO:0001682,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0006400,GO:0006409,GO:0008033,GO:0008266,GO:0008334,GO:0042780,GO:0071045,GO:0075522,GO:1903608,GO:1990825,GO:1990904" "tRNA binding|chromosome, telomeric region|tRNA 5'-leader removal|RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|tRNA modification|tRNA export from nucleus|tRNA processing|poly(U) RNA binding|histone mRNA metabolic process|tRNA 3'-end processing|nuclear histone mRNA catabolic process|IRES-dependent viral translational initiation|protein localization to cytoplasmic stress granule|sequence-specific mRNA binding|ribonucleoprotein complex" hsa05322 Systemic lupus erythematosus SSBP1 1303.166618 1194.395137 1411.938099 1.18213651 0.241396644 0.316135174 1 49.45125933 57.47992133 6742 single stranded DNA binding protein 1 "GO:0003682,GO:0003697,GO:0003723,GO:0005515,GO:0005634,GO:0005739,GO:0005759,GO:0006264,GO:0006268,GO:0007005,GO:0009295,GO:0042645,GO:0051096,GO:0070062,GO:0070584,GO:1905776" chromatin binding|single-stranded DNA binding|RNA binding|protein binding|nucleus|mitochondrion|mitochondrial matrix|mitochondrial DNA replication|DNA unwinding involved in DNA replication|mitochondrion organization|nucleoid|mitochondrial nucleoid|positive regulation of helicase activity|extracellular exosome|mitochondrion morphogenesis|positive regulation of DNA helicase activity "hsa03030,hsa03430,hsa03440" DNA replication|Mismatch repair|Homologous recombination SSBP2 401.8255131 342.2961674 461.3548589 1.347823618 0.430631712 0.136102101 1 1.793590313 2.376990745 23635 single stranded DNA binding protein 2 "GO:0003697,GO:0005634,GO:0005737,GO:0006355,GO:0045944" "single-stranded DNA binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II" SSBP3 640.5470077 654.4203322 626.6736833 0.957601182 -0.062503163 0.815222802 1 8.659858754 8.153924022 23648 single stranded DNA binding protein 3 "GO:0003697,GO:0005515,GO:0005634,GO:0045944" single-stranded DNA binding|protein binding|nucleus|positive regulation of transcription by RNA polymerase II SSBP4 524.1735239 538.9343912 509.4126567 0.945222025 -0.081274848 0.769454303 1 8.009450832 7.444023768 170463 single stranded DNA binding protein 4 "GO:0003697,GO:0005515,GO:0005634,GO:0045944" single-stranded DNA binding|protein binding|nucleus|positive regulation of transcription by RNA polymerase II SSC4D 20.73405014 27.05076095 14.41733934 0.532973522 -0.907864232 0.286166467 1 0.500225015 0.262145386 136853 scavenger receptor cysteine rich family member with 4 domains "GO:0005044,GO:0005576,GO:0006897,GO:0016020" scavenger receptor activity|extracellular region|endocytosis|membrane SSC5D 9.606529142 12.48496659 6.728091692 0.53889545 -0.891922689 0.47680615 1 0.12806068 0.067856507 284297 scavenger receptor cysteine rich family member with 5 domains "GO:0001968,GO:0005044,GO:0005515,GO:0005615,GO:0005737,GO:0006897,GO:0006952,GO:0007275,GO:0016020,GO:0031012,GO:0032717,GO:0042494,GO:0043236,GO:0045087,GO:0050829,GO:0050830,GO:0050840,GO:0062023" fibronectin binding|scavenger receptor activity|protein binding|extracellular space|cytoplasm|endocytosis|defense response|multicellular organism development|membrane|extracellular matrix|negative regulation of interleukin-8 production|detection of bacterial lipoprotein|laminin binding|innate immune response|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|extracellular matrix binding|collagen-containing extracellular matrix SSH1 2508.093498 2989.109085 2027.077911 0.678154545 -0.560314008 0.017946905 0.773499658 10.03985513 6.69464113 54434 slingshot protein phosphatase 1 "GO:0000902,GO:0003779,GO:0004721,GO:0004725,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006470,GO:0008138,GO:0030027,GO:0030036,GO:0030426,GO:0030496,GO:0030837,GO:0031915,GO:0032154,GO:0032268,GO:0035335,GO:0045202,GO:0071318,GO:0098976,GO:0106306,GO:0106307,GO:1901216,GO:1904719,GO:1904754,GO:2000463" cell morphogenesis|actin binding|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|lamellipodium|actin cytoskeleton organization|growth cone|midbody|negative regulation of actin filament polymerization|positive regulation of synaptic plasticity|cleavage furrow|regulation of cellular protein metabolic process|peptidyl-tyrosine dephosphorylation|synapse|cellular response to ATP|excitatory chemical synaptic transmission|protein serine phosphatase activity|protein threonine phosphatase activity|positive regulation of neuron death|positive regulation of AMPA glutamate receptor clustering|positive regulation of vascular associated smooth muscle cell migration|positive regulation of excitatory postsynaptic potential "hsa04360,hsa04810" Axon guidance|Regulation of actin cytoskeleton SSH2 811.53719 891.6346974 731.4396825 0.820335598 -0.285713861 0.255586464 1 3.424113481 2.761918671 85464 slingshot protein phosphatase 2 "GO:0003779,GO:0004721,GO:0004725,GO:0005615,GO:0005737,GO:0005856,GO:0006470,GO:0008138,GO:0030036,GO:0030837,GO:0035335,GO:0106306,GO:0106307" actin binding|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|extracellular space|cytoplasm|cytoskeleton|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|actin cytoskeleton organization|negative regulation of actin filament polymerization|peptidyl-tyrosine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity "hsa04360,hsa04810" Axon guidance|Regulation of actin cytoskeleton SSH3 968.7994309 1008.161052 929.4378094 0.921914021 -0.117295886 0.636635497 1 18.54021449 16.80646412 54961 slingshot protein phosphatase 3 "GO:0003779,GO:0004721,GO:0004725,GO:0005515,GO:0005634,GO:0005737,GO:0005856,GO:0008138,GO:0030036,GO:0030837,GO:0035335,GO:0106306,GO:0106307" actin binding|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|cytoskeleton|protein tyrosine/serine/threonine phosphatase activity|actin cytoskeleton organization|negative regulation of actin filament polymerization|peptidyl-tyrosine dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity "hsa04360,hsa04810" Axon guidance|Regulation of actin cytoskeleton SSNA1 658.140309 624.2483296 692.0322883 1.108584926 0.148719296 0.568303363 1 38.60369181 42.07934658 8636 SS nuclear autoantigen 1 "GO:0000086,GO:0005515,GO:0005634,GO:0005813,GO:0005829,GO:0010389,GO:0036064,GO:0042073,GO:0042802,GO:0060830,GO:0097711" G2/M transition of mitotic cell cycle|protein binding|nucleus|centrosome|cytosol|regulation of G2/M transition of mitotic cell cycle|ciliary basal body|intraciliary transport|identical protein binding|ciliary receptor clustering involved in smoothened signaling pathway|ciliary basal body-plasma membrane docking SSPN 128.1055001 120.6880104 135.5229898 1.122920076 0.167255247 0.71001836 1 1.220097992 1.347146221 8082 sarcospan "GO:0005887,GO:0006936,GO:0007155,GO:0016010,GO:0030133,GO:0042383,GO:0045211" integral component of plasma membrane|muscle contraction|cell adhesion|dystrophin-associated glycoprotein complex|transport vesicle|sarcolemma|postsynaptic membrane SSR1 3440.555742 3434.406227 3446.705258 1.003581123 0.00515724 0.984041881 1 18.97194371 18.72127789 6745 signal sequence receptor subunit 1 "GO:0005515,GO:0005783,GO:0005789,GO:0006613,GO:0008284,GO:0016021,GO:0036498" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cotranslational protein targeting to membrane|positive regulation of cell population proliferation|integral component of membrane|IRE1-mediated unfolded protein response hsa04141 Protein processing in endoplasmic reticulum SSR2 3843.549388 3958.774823 3728.323953 0.941787326 -0.086526788 0.716694648 1 190.6791845 176.5742238 6746 signal sequence receptor subunit 2 "GO:0005515,GO:0005783,GO:0005789,GO:0006613,GO:0016021" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cotranslational protein targeting to membrane|integral component of membrane hsa04141 Protein processing in endoplasmic reticulum SSR3 10416.79886 9167.08672 11666.51099 1.272651972 0.347837944 0.168204841 1 108.3087381 135.5327746 6747 signal sequence receptor subunit 3 "GO:0005515,GO:0005783,GO:0005789,GO:0006614,GO:0016021" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|SRP-dependent cotranslational protein targeting to membrane|integral component of membrane hsa04141 Protein processing in endoplasmic reticulum SSR4 2557.710573 2399.194413 2716.226732 1.132141154 0.179053843 0.449178416 1 76.99374402 85.70915135 6748 signal sequence receptor subunit 4 "GO:0005783,GO:0005784,GO:0012505,GO:0016021,GO:0070062" endoplasmic reticulum|Sec61 translocon complex|endomembrane system|integral component of membrane|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum SSRP1 4957.326082 4760.933927 5153.718236 1.082501525 0.114369057 0.63397996 1 68.11857733 72.50455051 6749 structure specific recognition protein 1 "GO:0003677,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006260,GO:0006281,GO:0006366,GO:0006368,GO:0016032,GO:0031491,GO:0035101,GO:0042393,GO:1901796,GO:1902275" DNA binding|RNA binding|protein binding|nucleoplasm|nucleolus|DNA replication|DNA repair|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|viral process|nucleosome binding|FACT complex|histone binding|regulation of signal transduction by p53 class mediator|regulation of chromatin organization SSTR2 9.249868472 3.121241648 15.3784953 4.927044116 2.300722389 0.071472036 1 0.021675332 0.105008244 6752 somatostatin receptor 2 "GO:0004930,GO:0004994,GO:0005515,GO:0005829,GO:0005886,GO:0005887,GO:0006937,GO:0007186,GO:0007187,GO:0007193,GO:0007218,GO:0007283,GO:0008285,GO:0021549,GO:0030165,GO:0030432,GO:0030900,GO:0038170,GO:0042277,GO:0042594,GO:0042923,GO:0043005,GO:0071385,GO:0071392" "G protein-coupled receptor activity|somatostatin receptor activity|protein binding|cytosol|plasma membrane|integral component of plasma membrane|regulation of muscle contraction|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|spermatogenesis|negative regulation of cell population proliferation|cerebellum development|PDZ domain binding|peristalsis|forebrain development|somatostatin signaling pathway|peptide binding|response to starvation|neuropeptide binding|neuron projection|cellular response to glucocorticoid stimulus|cellular response to estradiol stimulus" "hsa04024,hsa04080,hsa04935,hsa04971" "cAMP signaling pathway|Neuroactive ligand-receptor interaction|Growth hormone synthesis, secretion and action|Gastric acid secretion" SSU72 1124.228679 1101.798302 1146.659056 1.04071594 0.057576344 0.816184278 1 45.79513267 46.8622036 29101 "SSU72 homolog, RNA polymerase II CTD phosphatase" "GO:0005515,GO:0005654,GO:0005829,GO:0005847,GO:0006369,GO:0006378,GO:0008420,GO:0070940,GO:0106306,GO:0106307" protein binding|nucleoplasm|cytosol|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|RNA polymerase II CTD heptapeptide repeat phosphatase activity|dephosphorylation of RNA polymerase II C-terminal domain|protein serine phosphatase activity|protein threonine phosphatase activity hsa03015 mRNA surveillance pathway SSUH2 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.014182625 0.012882956 51066 ssu-2 homolog "GO:0005634,GO:0005737,GO:0042476" nucleus|cytoplasm|odontogenesis SSX2IP 626.4517305 650.2586767 602.6447844 0.926776998 -0.109705857 0.678149257 1 5.734155725 5.225356291 117178 SSX family member 2 interacting protein "GO:0005515,GO:0005634,GO:0005737,GO:0005912,GO:0007098,GO:0007155,GO:0019904,GO:0031252,GO:0032991,GO:0034451,GO:0035020,GO:0035735,GO:0036064,GO:0060271,GO:2000145" protein binding|nucleus|cytoplasm|adherens junction|centrosome cycle|cell adhesion|protein domain specific binding|cell leading edge|protein-containing complex|centriolar satellite|regulation of Rac protein signal transduction|intraciliary transport involved in cilium assembly|ciliary basal body|cilium assembly|regulation of cell motility hsa04520 Adherens junction ST13 9354.853545 8640.637295 10069.06979 1.165315642 0.220720782 0.377022018 1 143.5662925 164.5005066 6767 ST13 Hsp70 interacting protein "GO:0005515,GO:0005737,GO:0005829,GO:0006457,GO:0009617,GO:0019904,GO:0030544,GO:0030674,GO:0031072,GO:0032564,GO:0032991,GO:0042802,GO:0044877,GO:0046983,GO:0051082,GO:0051085,GO:0051087,GO:0061084,GO:0065003,GO:0070062" protein binding|cytoplasm|cytosol|protein folding|response to bacterium|protein domain specific binding|Hsp70 protein binding|protein-macromolecule adaptor activity|heat shock protein binding|dATP binding|protein-containing complex|identical protein binding|protein-containing complex binding|protein dimerization activity|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding|negative regulation of protein refolding|protein-containing complex assembly|extracellular exosome ST18 10.16636505 14.56579436 5.766935736 0.395923188 -1.336707531 0.252942837 1 0.058241528 0.022673307 9705 ST18 C2H2C-type zinc finger transcription factor "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0008270,GO:0008285,GO:0032993,GO:0033209,GO:0045944,GO:0070102,GO:0070498,GO:2001269" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding|negative regulation of cell population proliferation|protein-DNA complex|tumor necrosis factor-mediated signaling pathway|positive regulation of transcription by RNA polymerase II|interleukin-6-mediated signaling pathway|interleukin-1-mediated signaling pathway|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway" ST20-MTHFS 17.37503472 14.56579436 20.18427508 1.385731158 0.470647391 0.640298426 1 0.34274677 0.467007151 100528021 ST20-MTHFS readthrough hsa00670 One carbon pool by folate ST3GAL1 1530.427855 1622.005243 1438.850466 0.887081267 -0.172861817 0.469175748 1 8.685004385 7.575383588 6482 "ST3 beta-galactoside alpha-2,3-sialyltransferase 1" "GO:0000139,GO:0002319,GO:0003836,GO:0006054,GO:0006464,GO:0006468,GO:0006487,GO:0010706,GO:0016020,GO:0016021,GO:0016266,GO:0018146,GO:0032588,GO:0047288,GO:0070062,GO:0097503,GO:1905403,GO:1990675,GO:1990676,GO:1990743" "Golgi membrane|memory B cell differentiation|beta-galactoside (CMP) alpha-2,3-sialyltransferase activity|N-acetylneuraminate metabolic process|cellular protein modification process|protein phosphorylation|protein N-linked glycosylation|ganglioside biosynthetic process via lactosylceramide|membrane|integral component of membrane|O-glycan processing|keratan sulfate biosynthetic process|trans-Golgi network membrane|monosialoganglioside sialyltransferase activity|extracellular exosome|sialylation|negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process|Golgi medial cisterna membrane|Golgi trans cisterna membrane|protein sialylation" "hsa00512,hsa00533,hsa00603,hsa00604" Mucin type O-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - globo and isoglobo series|Glycosphingolipid biosynthesis - ganglio series ST3GAL2 731.0089097 770.946687 691.0711324 0.896392895 -0.157796882 0.537701517 1 5.194950473 4.578792844 6483 "ST3 beta-galactoside alpha-2,3-sialyltransferase 2" "GO:0000139,GO:0003836,GO:0005576,GO:0006486,GO:0009101,GO:0009247,GO:0009312,GO:0010706,GO:0010707,GO:0016021,GO:0016266,GO:0018146,GO:0030259,GO:0032580,GO:0042803,GO:0047288,GO:0097503,GO:1990743" "Golgi membrane|beta-galactoside (CMP) alpha-2,3-sialyltransferase activity|extracellular region|protein glycosylation|glycoprotein biosynthetic process|glycolipid biosynthetic process|oligosaccharide biosynthetic process|ganglioside biosynthetic process via lactosylceramide|globoside biosynthetic process via lactosylceramide|integral component of membrane|O-glycan processing|keratan sulfate biosynthetic process|lipid glycosylation|Golgi cisterna membrane|protein homodimerization activity|monosialoganglioside sialyltransferase activity|sialylation|protein sialylation" "hsa00512,hsa00533,hsa00603,hsa00604" Mucin type O-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - globo and isoglobo series|Glycosphingolipid biosynthesis - ganglio series ST3GAL3 598.5932991 612.8037769 584.3828212 0.953621442 -0.06851142 0.799981442 1 4.930530874 4.623180702 6487 "ST3 beta-galactoside alpha-2,3-sialyltransferase 3" "GO:0000139,GO:0005515,GO:0005576,GO:0006486,GO:0008118,GO:0008373,GO:0016021,GO:0016266,GO:0018146,GO:0032580,GO:0097503" "Golgi membrane|protein binding|extracellular region|protein glycosylation|N-acetyllactosaminide alpha-2,3-sialyltransferase activity|sialyltransferase activity|integral component of membrane|O-glycan processing|keratan sulfate biosynthetic process|Golgi cisterna membrane|sialylation" "hsa00513,hsa00514,hsa00515,hsa00533,hsa00601" Various types of N-glycan biosynthesis|Other types of O-glycan biosynthesis|Mannose type O-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - lacto and neolacto series ST3GAL4 748.3097169 770.946687 725.6727468 0.941274875 -0.087312008 0.734755333 1 14.10974203 13.05890368 6484 "ST3 beta-galactoside alpha-2,3-sialyltransferase 4" "GO:0000139,GO:0003836,GO:0004513,GO:0005576,GO:0006486,GO:0008118,GO:0008373,GO:0009101,GO:0009247,GO:0009312,GO:0016020,GO:0016021,GO:0016266,GO:0018146,GO:0030194,GO:0030259,GO:0032580,GO:0047288,GO:0050890,GO:0097503,GO:1903238,GO:1990743" "Golgi membrane|beta-galactoside (CMP) alpha-2,3-sialyltransferase activity|neolactotetraosylceramide alpha-2,3-sialyltransferase activity|extracellular region|protein glycosylation|N-acetyllactosaminide alpha-2,3-sialyltransferase activity|sialyltransferase activity|glycoprotein biosynthetic process|glycolipid biosynthetic process|oligosaccharide biosynthetic process|membrane|integral component of membrane|O-glycan processing|keratan sulfate biosynthetic process|positive regulation of blood coagulation|lipid glycosylation|Golgi cisterna membrane|monosialoganglioside sialyltransferase activity|cognition|sialylation|positive regulation of leukocyte tethering or rolling|protein sialylation" hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series ST3GAL5 82.22790966 76.99062732 87.465192 1.136049868 0.184026165 0.731929597 1 0.57740982 0.644989641 8869 "ST3 beta-galactoside alpha-2,3-sialyltransferase 5" "GO:0000139,GO:0001574,GO:0004513,GO:0005887,GO:0005975,GO:0006486,GO:0006688,GO:0008373,GO:0016021,GO:0047291,GO:0097503" "Golgi membrane|ganglioside biosynthetic process|neolactotetraosylceramide alpha-2,3-sialyltransferase activity|integral component of plasma membrane|carbohydrate metabolic process|protein glycosylation|glycosphingolipid biosynthetic process|sialyltransferase activity|integral component of membrane|lactosylceramide alpha-2,3-sialyltransferase activity|sialylation" hsa00604 Glycosphingolipid biosynthesis - ganglio series ST3GAL6 152.1539063 171.6682906 132.6395219 0.7726501 -0.372112867 0.359386512 1 2.150110575 1.633483827 10402 "ST3 beta-galactoside alpha-2,3-sialyltransferase 6" "GO:0000139,GO:0006464,GO:0006486,GO:0006664,GO:0008373,GO:0009311,GO:0016021,GO:0018146,GO:0052798,GO:0070062,GO:0071354,GO:0097503" "Golgi membrane|cellular protein modification process|protein glycosylation|glycolipid metabolic process|sialyltransferase activity|oligosaccharide metabolic process|integral component of membrane|keratan sulfate biosynthetic process|beta-galactoside alpha-2,3-sialyltransferase activity|extracellular exosome|cellular response to interleukin-6|sialylation" hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series ST6GAL1 23.22122838 16.64662212 29.79583464 1.789902745 0.8398812 0.304457087 1 0.18593546 0.327237326 6480 "ST6 beta-galactoside alpha-2,6-sialyltransferase 1" "GO:0000139,GO:0003835,GO:0005515,GO:0005576,GO:0006054,GO:0006959,GO:0008373,GO:0016021,GO:0016266,GO:0018279,GO:0032580,GO:0042803,GO:0097503" "Golgi membrane|beta-galactoside alpha-2,6-sialyltransferase activity|protein binding|extracellular region|N-acetylneuraminate metabolic process|humoral immune response|sialyltransferase activity|integral component of membrane|O-glycan processing|protein N-linked glycosylation via asparagine|Golgi cisterna membrane|protein homodimerization activity|sialylation" "hsa00510,hsa00514" N-Glycan biosynthesis|Other types of O-glycan biosynthesis ST6GALNAC2 6.485287494 6.242483296 6.728091692 1.0777909 0.108077311 1 1 0.147803842 0.156635939 10610 "ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2" "GO:0000139,GO:0001665,GO:0006486,GO:0006493,GO:0008373,GO:0016021,GO:0016266,GO:1990743" "Golgi membrane|alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity|protein glycosylation|protein O-linked glycosylation|sialyltransferase activity|integral component of membrane|O-glycan processing|protein sialylation" ST6GALNAC4 587.5695737 638.8141239 536.3250234 0.839563503 -0.252288643 0.340252342 1 18.9401865 15.63539943 27090 "ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4" "GO:0000139,GO:0001574,GO:0001665,GO:0006664,GO:0008373,GO:0009311,GO:0016021,GO:0016266,GO:0047290,GO:0097503" "Golgi membrane|ganglioside biosynthetic process|alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity|glycolipid metabolic process|sialyltransferase activity|oligosaccharide metabolic process|integral component of membrane|O-glycan processing|(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity|sialylation" hsa00604 Glycosphingolipid biosynthesis - ganglio series ST6GALNAC6 983.1079441 980.0698774 986.1460108 1.006199694 0.008916656 0.975744602 1 15.85946879 15.6907606 30815 "ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6" "GO:0000139,GO:0001574,GO:0001665,GO:0005515,GO:0005737,GO:0005886,GO:0006486,GO:0006677,GO:0006687,GO:0008373,GO:0009100,GO:0009311,GO:0009312,GO:0009988,GO:0016021,GO:0097503" "Golgi membrane|ganglioside biosynthetic process|alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity|protein binding|cytoplasm|plasma membrane|protein glycosylation|glycosylceramide metabolic process|glycosphingolipid metabolic process|sialyltransferase activity|glycoprotein metabolic process|oligosaccharide metabolic process|oligosaccharide biosynthetic process|cell-cell recognition|integral component of membrane|sialylation" hsa00604 Glycosphingolipid biosynthesis - ganglio series ST7 343.6409793 328.7707869 358.5111716 1.090459329 0.124935962 0.685747714 1 4.54792448 4.876339059 7982 suppression of tumorigenicity 7 "GO:0016021,GO:0030198,GO:0045595" integral component of membrane|extracellular matrix organization|regulation of cell differentiation ST7L 200.5583039 206.0019488 195.1146591 0.947149579 -0.078335813 0.841875707 1 1.73982361 1.620298273 54879 suppression of tumorigenicity 7 like "GO:0016021,GO:0030308" integral component of membrane|negative regulation of cell growth ST8SIA4 72.49243279 86.35435226 58.63051332 0.678952615 -0.558617204 0.289284428 1 0.537254962 0.358666719 7903 "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4" "GO:0000139,GO:0001574,GO:0003828,GO:0006464,GO:0006486,GO:0006491,GO:0007399,GO:0009311,GO:0016021,GO:0033691,GO:0097503" "Golgi membrane|ganglioside biosynthetic process|alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity|cellular protein modification process|protein glycosylation|N-glycan processing|nervous system development|oligosaccharide metabolic process|integral component of membrane|sialic acid binding|sialylation" ST8SIA6 22.69599102 28.09117483 17.30080721 0.615880514 -0.699277611 0.400507774 1 0.141191785 0.085502157 338596 "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6" "GO:0000139,GO:0001574,GO:0001835,GO:0003828,GO:0006486,GO:0006491,GO:0006493,GO:0008373,GO:0009100,GO:0009247,GO:0009311,GO:0016021,GO:0016051,GO:0097503" "Golgi membrane|ganglioside biosynthetic process|blastocyst hatching|alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity|protein glycosylation|N-glycan processing|protein O-linked glycosylation|sialyltransferase activity|glycoprotein metabolic process|glycolipid biosynthetic process|oligosaccharide metabolic process|integral component of membrane|carbohydrate biosynthetic process|sialylation" STAC 94.23229827 101.9605605 86.50403604 0.848406831 -0.237171858 0.632568068 1 1.493672171 1.2460361 6769 SH3 and cysteine rich domain "GO:0003009,GO:0005515,GO:0005829,GO:0007165,GO:0030315,GO:0031234,GO:0034605,GO:0035556,GO:0044325,GO:0046872,GO:1901387,GO:1903078,GO:2001259" skeletal muscle contraction|protein binding|cytosol|signal transduction|T-tubule|extrinsic component of cytoplasmic side of plasma membrane|cellular response to heat|intracellular signal transduction|ion channel binding|metal ion binding|positive regulation of voltage-gated calcium channel activity|positive regulation of protein localization to plasma membrane|positive regulation of cation channel activity STAC3 6.445658531 5.202069413 7.689247648 1.478113235 0.563756795 0.78195947 1 0.168257505 0.244541927 246329 SH3 and cysteine rich domain 3 "GO:0003009,GO:0005515,GO:0005654,GO:0005829,GO:0005891,GO:0007274,GO:0030315,GO:0031234,GO:0035556,GO:0042802,GO:0045202,GO:0046872,GO:0048741,GO:1901387,GO:1903078" skeletal muscle contraction|protein binding|nucleoplasm|cytosol|voltage-gated calcium channel complex|neuromuscular synaptic transmission|T-tubule|extrinsic component of cytoplasmic side of plasma membrane|intracellular signal transduction|identical protein binding|synapse|metal ion binding|skeletal muscle fiber development|positive regulation of voltage-gated calcium channel activity|positive regulation of protein localization to plasma membrane STAG1 871.4553374 975.9082219 767.0024529 0.785937074 -0.347514286 0.163038457 1 7.847284641 6.064267643 10274 stromal antigen 1 "GO:0000775,GO:0000785,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0007062,GO:0008278,GO:0016363,GO:0016604,GO:0051301,GO:0090307,GO:0097431" "chromosome, centromeric region|chromatin|chromatin binding|protein binding|nucleus|nucleoplasm|chromosome|cytosol|sister chromatid cohesion|cohesin complex|nuclear matrix|nuclear body|cell division|mitotic spindle assembly|mitotic spindle pole" hsa04110 Cell cycle other STAG2 5393.363908 5572.456755 5214.271061 0.935722122 -0.095847933 0.69105155 1 43.36421337 39.89785507 10735 stromal antigen 2 "GO:0000775,GO:0000785,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0007062,GO:0008278,GO:0016020,GO:0016363,GO:0051301,GO:0051321,GO:0090307,GO:0097431" "chromosome, centromeric region|chromatin|chromatin binding|protein binding|nucleus|nucleoplasm|chromosome|cytosol|sister chromatid cohesion|cohesin complex|membrane|nuclear matrix|cell division|meiotic cell cycle|mitotic spindle assembly|mitotic spindle pole" hsa04110 Cell cycle STAG3 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.035707381 0.021623482 10734 stromal antigen 3 "GO:0000775,GO:0000785,GO:0000795,GO:0003682,GO:0005615,GO:0005634,GO:0005654,GO:0005730,GO:0007062,GO:0007130,GO:0008278,GO:0030893" "chromosome, centromeric region|chromatin|synaptonemal complex|chromatin binding|extracellular space|nucleus|nucleoplasm|nucleolus|sister chromatid cohesion|synaptonemal complex assembly|cohesin complex|meiotic cohesin complex" hsa04114 Oocyte meiosis STAM 951.1375469 910.3621473 991.9129466 1.089580613 0.123772939 0.618638978 1 9.511424164 10.19004485 8027 signal transducing adaptor molecule "GO:0005515,GO:0005829,GO:0007165,GO:0016197,GO:0016236,GO:0016579,GO:0031901,GO:0033565,GO:0036258,GO:0042059,GO:0043231,GO:0043328,GO:0044389,GO:0061024,GO:1903543,GO:1903551" protein binding|cytosol|signal transduction|endosomal transport|macroautophagy|protein deubiquitination|early endosome membrane|ESCRT-0 complex|multivesicular body assembly|negative regulation of epidermal growth factor receptor signaling pathway|intracellular membrane-bounded organelle|protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|ubiquitin-like protein ligase binding|membrane organization|positive regulation of exosomal secretion|regulation of extracellular exosome assembly "hsa04144,hsa04630" Endocytosis|JAK-STAT signaling pathway STAM2 1342.746391 1362.942186 1322.550595 0.970364414 -0.043401452 0.859459967 1 13.2927119 12.68293106 10254 signal transducing adaptor molecule 2 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006886,GO:0007165,GO:0016197,GO:0016236,GO:0016579,GO:0030139,GO:0031901,GO:0033565,GO:0036258,GO:0042059,GO:0043231,GO:0061024" protein binding|nucleoplasm|cytoplasm|cytosol|intracellular protein transport|signal transduction|endosomal transport|macroautophagy|protein deubiquitination|endocytic vesicle|early endosome membrane|ESCRT-0 complex|multivesicular body assembly|negative regulation of epidermal growth factor receptor signaling pathway|intracellular membrane-bounded organelle|membrane organization "hsa04144,hsa04630" Endocytosis|JAK-STAT signaling pathway STAMBP 905.7009055 865.6243504 945.7774607 1.09259572 0.127759677 0.609122197 1 18.41976899 19.78859011 10617 STAM binding protein "GO:0000281,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0007259,GO:0008237,GO:0008284,GO:0014067,GO:0016020,GO:0016579,GO:0018215,GO:0019904,GO:0032154,GO:0046580,GO:0046872,GO:0061578,GO:0070062,GO:0070122,GO:0070536" mitotic cytokinesis|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|endosome|early endosome|cytosol|plasma membrane|receptor signaling pathway via JAK-STAT|metallopeptidase activity|positive regulation of cell population proliferation|negative regulation of phosphatidylinositol 3-kinase signaling|membrane|protein deubiquitination|protein phosphopantetheinylation|protein domain specific binding|cleavage furrow|negative regulation of Ras protein signal transduction|metal ion binding|Lys63-specific deubiquitinase activity|extracellular exosome|isopeptidase activity|protein K63-linked deubiquitination hsa04144 Endocytosis STAMBPL1 1021.286226 1048.737194 993.8352585 0.947649482 -0.077574563 0.754940143 1 12.33072847 11.48967231 57559 STAM binding protein like 1 "GO:0004843,GO:0005515,GO:0005768,GO:0005829,GO:0008237,GO:0016020,GO:0016579,GO:0018215,GO:0046872,GO:0061578,GO:0070122,GO:0070536" thiol-dependent ubiquitin-specific protease activity|protein binding|endosome|cytosol|metallopeptidase activity|membrane|protein deubiquitination|protein phosphopantetheinylation|metal ion binding|Lys63-specific deubiquitinase activity|isopeptidase activity|protein K63-linked deubiquitination STAP2 508.9736662 493.1561804 524.791152 1.064147978 0.089698782 0.747423782 1 17.38364529 18.18921909 55620 signal transducing adaptor family member 2 "GO:0005515,GO:0005829,GO:0005886,GO:0035591,GO:0042531" protein binding|cytosol|plasma membrane|signaling adaptor activity|positive regulation of tyrosine phosphorylation of STAT protein STARD10 1026.276288 889.5538697 1162.998707 1.307395478 0.386695612 0.114910637 1 20.3750451 26.19248693 10809 StAR related lipid transfer domain containing 10 "GO:0005515,GO:0005829,GO:0005902,GO:0006656,GO:0006869,GO:0008289,GO:0016020,GO:0031514,GO:0046581" protein binding|cytosol|microvillus|phosphatidylcholine biosynthetic process|lipid transport|lipid binding|membrane|motile cilium|intercellular canaliculus STARD13 1509.461675 1475.306886 1543.616465 1.046301946 0.06529925 0.786561876 1 9.160490632 9.424253218 90627 StAR related lipid transfer domain containing 13 "GO:0005096,GO:0005515,GO:0005811,GO:0005829,GO:0007165,GO:0008289,GO:0030036,GO:0031966,GO:0035023,GO:0043542,GO:0043547,GO:0051056,GO:0090051,GO:0097498" GTPase activator activity|protein binding|lipid droplet|cytosol|signal transduction|lipid binding|actin cytoskeleton organization|mitochondrial membrane|regulation of Rho protein signal transduction|endothelial cell migration|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|negative regulation of cell migration involved in sprouting angiogenesis|endothelial tube lumen extension STARD3 1187.025263 1198.556793 1175.493734 0.980757642 -0.028031423 0.911448721 1 19.43036852 18.73759799 10948 StAR related lipid transfer domain containing 3 "GO:0005515,GO:0005654,GO:0005737,GO:0005765,GO:0005768,GO:0005789,GO:0005829,GO:0006629,GO:0006700,GO:0006839,GO:0008202,GO:0008203,GO:0015485,GO:0016021,GO:0030301,GO:0031902,GO:0042803,GO:0043231,GO:0044232,GO:0099044,GO:0120009,GO:0120020,GO:0140284" protein binding|nucleoplasm|cytoplasm|lysosomal membrane|endosome|endoplasmic reticulum membrane|cytosol|lipid metabolic process|C21-steroid hormone biosynthetic process|mitochondrial transport|steroid metabolic process|cholesterol metabolic process|cholesterol binding|integral component of membrane|cholesterol transport|late endosome membrane|protein homodimerization activity|intracellular membrane-bounded organelle|organelle membrane contact site|vesicle tethering to endoplasmic reticulum|intermembrane lipid transfer|cholesterol transfer activity|endoplasmic reticulum-endosome membrane contact site hsa04979 Cholesterol metabolism STARD3NL 1362.148762 1216.243829 1508.053695 1.239927109 0.310255313 0.196047999 1 30.10607504 36.70468267 83930 STARD3 N-terminal like "GO:0005515,GO:0005765,GO:0005768,GO:0005789,GO:0005829,GO:0006700,GO:0015485,GO:0016020,GO:0016021,GO:0031902,GO:0042803,GO:0043231,GO:0044232,GO:0099044,GO:0140284" protein binding|lysosomal membrane|endosome|endoplasmic reticulum membrane|cytosol|C21-steroid hormone biosynthetic process|cholesterol binding|membrane|integral component of membrane|late endosome membrane|protein homodimerization activity|intracellular membrane-bounded organelle|organelle membrane contact site|vesicle tethering to endoplasmic reticulum|endoplasmic reticulum-endosome membrane contact site STARD4 1344.049731 1308.840664 1379.258797 1.053801914 0.075603705 0.755239689 1 6.909726057 7.159636793 134429 StAR related lipid transfer domain containing 4 "GO:0005515,GO:0005737,GO:0005783,GO:0005829,GO:0010873,GO:0010879,GO:0015485,GO:0031410,GO:0032367,GO:0070508,GO:0070859,GO:0120009,GO:0120020" protein binding|cytoplasm|endoplasmic reticulum|cytosol|positive regulation of cholesterol esterification|cholesterol transport involved in cholesterol storage|cholesterol binding|cytoplasmic vesicle|intracellular cholesterol transport|cholesterol import|positive regulation of bile acid biosynthetic process|intermembrane lipid transfer|cholesterol transfer activity STARD5 70.25308917 78.0310412 62.47513714 0.800644669 -0.320765987 0.557532993 1 0.852132853 0.670839002 80765 StAR related lipid transfer domain containing 5 "GO:0005829,GO:0015485,GO:0015721,GO:0032052,GO:0070508,GO:0120009,GO:0120020" cytosol|cholesterol binding|bile acid and bile salt transport|bile acid binding|cholesterol import|intermembrane lipid transfer|cholesterol transfer activity STARD6 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.087717183 0.119518418 147323 StAR related lipid transfer domain containing 6 "GO:0006869,GO:0008289" lipid transport|lipid binding STARD7 2586.276681 2568.781876 2603.771485 1.01362109 0.019518447 0.935915073 1 40.59554857 40.45993969 56910 StAR related lipid transfer domain containing 7 "GO:0005515,GO:0005741,GO:0006656,GO:0008289" protein binding|mitochondrial outer membrane|phosphatidylcholine biosynthetic process|lipid binding STARD8 187.4839333 152.9408407 222.0270258 1.451718356 0.537761587 0.149321068 1 1.564533559 2.23325559 9754 StAR related lipid transfer domain containing 8 "GO:0005096,GO:0005829,GO:0005925,GO:0007165,GO:0008289,GO:0030036,GO:0035023,GO:0043547,GO:0051056" GTPase activator activity|cytosol|focal adhesion|signal transduction|lipid binding|actin cytoskeleton organization|regulation of Rho protein signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction STARD9 618.5939062 671.0669543 566.1208581 0.843613077 -0.245346636 0.349066497 1 2.143757332 1.778238891 57519 StAR related lipid transfer domain containing 9 "GO:0003777,GO:0005524,GO:0005634,GO:0005737,GO:0005814,GO:0007018,GO:0008017,GO:0008289,GO:0051225" microtubule motor activity|ATP binding|nucleus|cytoplasm|centriole|microtubule-based movement|microtubule binding|lipid binding|spindle assembly STAT1 2999.532269 2870.501902 3128.562637 1.08990091 0.124196977 0.600439876 1 34.248471 36.70281557 6772 signal transducer and activator of transcription 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000979,GO:0000981,GO:0001937,GO:0002053,GO:0002230,GO:0003340,GO:0003690,GO:0003700,GO:0005164,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006952,GO:0007221,GO:0007259,GO:0008015,GO:0010742,GO:0016032,GO:0016525,GO:0019221,GO:0019899,GO:0030424,GO:0030425,GO:0032727,GO:0032991,GO:0033209,GO:0034097,GO:0035035,GO:0035257,GO:0035456,GO:0035458,GO:0038113,GO:0038114,GO:0042127,GO:0042393,GO:0042802,GO:0042803,GO:0042981,GO:0043124,GO:0043434,GO:0043542,GO:0044389,GO:0045296,GO:0045648,GO:0045893,GO:0045944,GO:0046725,GO:0048471,GO:0048661,GO:0051591,GO:0051607,GO:0060333,GO:0060334,GO:0060337,GO:0061326,GO:0070102,GO:0070106,GO:0070491,GO:0070757,GO:0071346,GO:0072136,GO:0072162,GO:0072308,GO:1990841" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|negative regulation of endothelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of defense response to virus by host|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|double-stranded DNA binding|DNA-binding transcription factor activity|tumor necrosis factor receptor binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|defense response|positive regulation of transcription of Notch receptor target|receptor signaling pathway via JAK-STAT|blood circulation|macrophage derived foam cell differentiation|viral process|negative regulation of angiogenesis|cytokine-mediated signaling pathway|enzyme binding|axon|dendrite|positive regulation of interferon-alpha production|protein-containing complex|tumor necrosis factor-mediated signaling pathway|response to cytokine|histone acetyltransferase binding|nuclear hormone receptor binding|response to interferon-beta|cellular response to interferon-beta|interleukin-9-mediated signaling pathway|interleukin-21-mediated signaling pathway|regulation of cell population proliferation|histone binding|identical protein binding|protein homodimerization activity|regulation of apoptotic process|negative regulation of I-kappaB kinase/NF-kappaB signaling|response to peptide hormone|endothelial cell migration|ubiquitin-like protein ligase binding|cadherin binding|positive regulation of erythrocyte differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation by virus of viral protein levels in host cell|perinuclear region of cytoplasm|positive regulation of smooth muscle cell proliferation|response to cAMP|defense response to virus|interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|renal tubule development|interleukin-6-mediated signaling pathway|interleukin-27-mediated signaling pathway|repressing transcription factor binding|interleukin-35-mediated signaling pathway|cellular response to interferon-gamma|metanephric mesenchymal cell proliferation involved in metanephros development|metanephric mesenchymal cell differentiation|negative regulation of metanephric nephron tubule epithelial cell differentiation|promoter-specific chromatin binding" "hsa04062,hsa04217,hsa04380,hsa04620,hsa04621,hsa04625,hsa04630,hsa04658,hsa04659,hsa04917,hsa04919,hsa04933,hsa04935,hsa05140,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05171,hsa05200,hsa05212,hsa05235,hsa05321" "Chemokine signaling pathway|Necroptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Prolactin signaling pathway|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Leishmaniasis|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Pathways in cancer|Pancreatic cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease" STAT STAT2 1838.809233 1794.713948 1882.904518 1.049139068 0.069205926 0.772033396 1 20.15584698 20.79243204 6773 signal transducer and activator of transcription 2 "GO:0000785,GO:0000978,GO:0000981,GO:0001932,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006357,GO:0006952,GO:0007259,GO:0016032,GO:0019221,GO:0042127,GO:0042802,GO:0043434,GO:0044389,GO:0051607,GO:0060337,GO:0090140" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|regulation of protein phosphorylation|protein binding|nucleoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|defense response|receptor signaling pathway via JAK-STAT|viral process|cytokine-mediated signaling pathway|regulation of cell population proliferation|identical protein binding|response to peptide hormone|ubiquitin-like protein ligase binding|defense response to virus|type I interferon signaling pathway|regulation of mitochondrial fission" "hsa04062,hsa04217,hsa04380,hsa04621,hsa04625,hsa04630,hsa05160,hsa05161,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05171,hsa05200" Chemokine signaling pathway|Necroptosis|Osteoclast differentiation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Pathways in cancer STAT STAT3 2007.84692 2106.838112 1908.855729 0.906028668 -0.142371395 0.548132255 1 22.26937569 19.83906316 6774 signal transducer and activator of transcription 3 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001103,GO:0001228,GO:0001659,GO:0001754,GO:0003677,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006357,GO:0006606,GO:0006952,GO:0006954,GO:0007165,GO:0007259,GO:0007399,GO:0008134,GO:0010507,GO:0010628,GO:0016032,GO:0016310,GO:0019221,GO:0019901,GO:0019903,GO:0019953,GO:0030335,GO:0030522,GO:0031490,GO:0032355,GO:0032731,GO:0032733,GO:0032755,GO:0032757,GO:0032760,GO:0032870,GO:0033210,GO:0035019,GO:0035723,GO:0038111,GO:0038113,GO:0038114,GO:0038155,GO:0042127,GO:0042531,GO:0042593,GO:0042755,GO:0042802,GO:0042803,GO:0043434,GO:0044320,GO:0044321,GO:0045648,GO:0045747,GO:0045893,GO:0045944,GO:0046983,GO:0048708,GO:0051092,GO:0051726,GO:0060019,GO:0060259,GO:0060396,GO:0060397,GO:0070102,GO:0070106,GO:0070757,GO:0070878,GO:0071345,GO:0072538,GO:0072540,GO:0090575,GO:0097009,GO:1900017,GO:1902895,GO:1904685,GO:1905618,GO:2000635,GO:2000637" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II repressing transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|temperature homeostasis|eye photoreceptor cell differentiation|DNA binding|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|plasma membrane|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|protein import into nucleus|defense response|inflammatory response|signal transduction|receptor signaling pathway via JAK-STAT|nervous system development|transcription factor binding|negative regulation of autophagy|positive regulation of gene expression|viral process|phosphorylation|cytokine-mediated signaling pathway|protein kinase binding|protein phosphatase binding|sexual reproduction|positive regulation of cell migration|intracellular receptor signaling pathway|chromatin DNA binding|response to estradiol|positive regulation of interleukin-1 beta production|positive regulation of interleukin-10 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|cellular response to hormone stimulus|leptin-mediated signaling pathway|somatic stem cell population maintenance|interleukin-15-mediated signaling pathway|interleukin-7-mediated signaling pathway|interleukin-9-mediated signaling pathway|interleukin-21-mediated signaling pathway|interleukin-23-mediated signaling pathway|regulation of cell population proliferation|positive regulation of tyrosine phosphorylation of STAT protein|glucose homeostasis|eating behavior|identical protein binding|protein homodimerization activity|response to peptide hormone|cellular response to leptin stimulus|response to leptin|positive regulation of erythrocyte differentiation|positive regulation of Notch signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|astrocyte differentiation|positive regulation of NF-kappaB transcription factor activity|regulation of cell cycle|radial glial cell differentiation|regulation of feeding behavior|growth hormone receptor signaling pathway|growth hormone receptor signaling pathway via JAK-STAT|interleukin-6-mediated signaling pathway|interleukin-27-mediated signaling pathway|interleukin-35-mediated signaling pathway|primary miRNA binding|cellular response to cytokine stimulus|T-helper 17 type immune response|T-helper 17 cell lineage commitment|RNA polymerase II transcription regulator complex|energy homeostasis|positive regulation of cytokine production involved in inflammatory response|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of metalloendopeptidase activity|positive regulation of miRNA mediated inhibition of translation|negative regulation of primary miRNA processing|positive regulation of gene silencing by miRNA" "hsa01521,hsa04062,hsa04066,hsa04068,hsa04217,hsa04550,hsa04630,hsa04659,hsa04917,hsa04920,hsa04931,hsa04933,hsa04935,hsa05145,hsa05160,hsa05161,hsa05162,hsa05163,hsa05167,hsa05169,hsa05171,hsa05200,hsa05203,hsa05205,hsa05206,hsa05212,hsa05221,hsa05223,hsa05235,hsa05321" "EGFR tyrosine kinase inhibitor resistance|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Necroptosis|Signaling pathways regulating pluripotency of stem cells|JAK-STAT signaling pathway|Th17 cell differentiation|Prolactin signaling pathway|Adipocytokine signaling pathway|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Toxoplasmosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Pancreatic cancer|Acute myeloid leukemia|Non-small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease" STAT STAT4 134.1347473 165.4258073 102.8436873 0.621690708 -0.685731079 0.104270805 1 2.370059409 1.448787824 6775 signal transducer and activator of transcription 4 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0006952,GO:0007259,GO:0019221,GO:0035722,GO:0038114,GO:0038155,GO:0042127,GO:0042802,GO:0043434,GO:0045944,GO:0070757" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|defense response|receptor signaling pathway via JAK-STAT|cytokine-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-21-mediated signaling pathway|interleukin-23-mediated signaling pathway|regulation of cell population proliferation|identical protein binding|response to peptide hormone|positive regulation of transcription by RNA polymerase II|interleukin-35-mediated signaling pathway" "hsa04217,hsa04630,hsa04658,hsa05161,hsa05200,hsa05321" Necroptosis|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Hepatitis B|Pathways in cancer|Inflammatory bowel disease STAT STAT5A 152.3570815 164.3853935 140.3287696 0.853657169 -0.228271299 0.57959208 1 2.039745715 1.7121062 6776 signal transducer and activator of transcription 5A "GO:0000785,GO:0000978,GO:0000981,GO:0001938,GO:0003700,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0006952,GO:0007259,GO:0007595,GO:0019221,GO:0019530,GO:0035723,GO:0038026,GO:0038110,GO:0038111,GO:0038113,GO:0040014,GO:0042127,GO:0043434,GO:0043536,GO:0060397" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|positive regulation of endothelial cell proliferation|DNA-binding transcription factor activity|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|defense response|receptor signaling pathway via JAK-STAT|lactation|cytokine-mediated signaling pathway|taurine metabolic process|interleukin-15-mediated signaling pathway|reelin-mediated signaling pathway|interleukin-2-mediated signaling pathway|interleukin-7-mediated signaling pathway|interleukin-9-mediated signaling pathway|regulation of multicellular organism growth|regulation of cell population proliferation|response to peptide hormone|positive regulation of blood vessel endothelial cell migration|growth hormone receptor signaling pathway via JAK-STAT" "hsa04012,hsa04217,hsa04630,hsa04658,hsa04659,hsa04917,hsa04933,hsa04935,hsa05161,hsa05162,hsa05166,hsa05200,hsa05203,hsa05220,hsa05221,hsa05223" "ErbB signaling pathway|Necroptosis|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Prolactin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Hepatitis B|Measles|Human T-cell leukemia virus 1 infection|Pathways in cancer|Viral carcinogenesis|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer" STAT STAT5B 1519.320455 1557.499582 1481.141328 0.95097382 -0.072522469 0.763167993 1 12.93307766 12.09321086 6777 signal transducer and activator of transcription 5B "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001553,GO:0001779,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006952,GO:0007259,GO:0007565,GO:0007595,GO:0019218,GO:0019221,GO:0019530,GO:0019915,GO:0030856,GO:0032355,GO:0032743,GO:0032819,GO:0032825,GO:0032870,GO:0033077,GO:0035259,GO:0035723,GO:0038110,GO:0038111,GO:0038113,GO:0040014,GO:0040018,GO:0042104,GO:0042127,GO:0042448,GO:0042802,GO:0043029,GO:0043066,GO:0043434,GO:0045579,GO:0045588,GO:0045647,GO:0045648,GO:0045931,GO:0045944,GO:0045954,GO:0046543,GO:0046544,GO:0046983,GO:0048541,GO:0050729,GO:0060397,GO:0070670,GO:0071363,GO:0071364,GO:0097531" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|luteinization|natural killer cell differentiation|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|defense response|receptor signaling pathway via JAK-STAT|female pregnancy|lactation|regulation of steroid metabolic process|cytokine-mediated signaling pathway|taurine metabolic process|lipid storage|regulation of epithelial cell differentiation|response to estradiol|positive regulation of interleukin-2 production|positive regulation of natural killer cell proliferation|positive regulation of natural killer cell differentiation|cellular response to hormone stimulus|T cell differentiation in thymus|glucocorticoid receptor binding|interleukin-15-mediated signaling pathway|interleukin-2-mediated signaling pathway|interleukin-7-mediated signaling pathway|interleukin-9-mediated signaling pathway|regulation of multicellular organism growth|positive regulation of multicellular organism growth|positive regulation of activated T cell proliferation|regulation of cell population proliferation|progesterone metabolic process|identical protein binding|T cell homeostasis|negative regulation of apoptotic process|response to peptide hormone|positive regulation of B cell differentiation|positive regulation of gamma-delta T cell differentiation|negative regulation of erythrocyte differentiation|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|positive regulation of natural killer cell mediated cytotoxicity|development of secondary female sexual characteristics|development of secondary male sexual characteristics|protein dimerization activity|Peyer's patch development|positive regulation of inflammatory response|growth hormone receptor signaling pathway via JAK-STAT|response to interleukin-4|cellular response to growth factor stimulus|cellular response to epidermal growth factor stimulus|mast cell migration" "hsa04012,hsa04062,hsa04217,hsa04630,hsa04658,hsa04659,hsa04917,hsa04933,hsa04935,hsa05161,hsa05162,hsa05166,hsa05200,hsa05203,hsa05220,hsa05221,hsa05223" "ErbB signaling pathway|Chemokine signaling pathway|Necroptosis|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Prolactin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Hepatitis B|Measles|Human T-cell leukemia virus 1 infection|Pathways in cancer|Viral carcinogenesis|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer" STAT STAT6 2984.498531 3207.596 2761.401062 0.860894284 -0.216092006 0.361426747 1 38.93188611 32.95538936 6778 signal transducer and activator of transcription 6 "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0003700,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0006952,GO:0007165,GO:0007259,GO:0019221,GO:0019903,GO:0032481,GO:0035771,GO:0042127,GO:0042802,GO:0043434,GO:0045944,GO:0060397,GO:0120162" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|defense response|signal transduction|receptor signaling pathway via JAK-STAT|cytokine-mediated signaling pathway|protein phosphatase binding|positive regulation of type I interferon production|interleukin-4-mediated signaling pathway|regulation of cell population proliferation|identical protein binding|response to peptide hormone|positive regulation of transcription by RNA polymerase II|growth hormone receptor signaling pathway via JAK-STAT|positive regulation of cold-induced thermogenesis" "hsa04217,hsa04630,hsa04658,hsa04659,hsa05161,hsa05200,hsa05321" Necroptosis|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Hepatitis B|Pathways in cancer|Inflammatory bowel disease STAT STAU1 5999.494813 5865.85347 6133.136155 1.045565865 0.064283946 0.791145795 1 74.34096859 76.42769994 6780 staufen double-stranded RNA binding protein 1 "GO:0003723,GO:0003725,GO:0005515,GO:0005737,GO:0005783,GO:0005791,GO:0005829,GO:0005875,GO:0005886,GO:0008157,GO:0010494,GO:0016020,GO:0016032,GO:0030425,GO:0034599,GO:0036464,GO:0043025,GO:0044297,GO:0045070,GO:0046726,GO:0070062,GO:0098978,GO:0099010,GO:1900273" RNA binding|double-stranded RNA binding|protein binding|cytoplasm|endoplasmic reticulum|rough endoplasmic reticulum|cytosol|microtubule associated complex|plasma membrane|protein phosphatase 1 binding|cytoplasmic stress granule|membrane|viral process|dendrite|cellular response to oxidative stress|cytoplasmic ribonucleoprotein granule|neuronal cell body|cell body|positive regulation of viral genome replication|positive regulation by virus of viral protein levels in host cell|extracellular exosome|glutamatergic synapse|modification of postsynaptic structure|positive regulation of long-term synaptic potentiation STAU2 1683.513963 1666.74304 1700.284886 1.020124186 0.02874479 0.90620404 1 15.91537175 15.96397393 27067 staufen double-stranded RNA binding protein 2 "GO:0003723,GO:0003725,GO:0005515,GO:0005730,GO:0005783,GO:0005874,GO:0016020" RNA binding|double-stranded RNA binding|protein binding|nucleolus|endoplasmic reticulum|microtubule|membrane STBD1 10.00784919 10.40413883 9.61155956 0.923820772 -0.11431511 1 1 0.247437508 0.2247628 8987 starch binding domain 1 "GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0005980,GO:0016020,GO:0019899,GO:0030247,GO:0030315,GO:0034045,GO:0043312,GO:0046907,GO:0048471,GO:0061723,GO:0070821,GO:0101003,GO:2001069,GO:2001070" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|glycogen catabolic process|membrane|enzyme binding|polysaccharide binding|T-tubule|phagophore assembly site membrane|neutrophil degranulation|intracellular transport|perinuclear region of cytoplasm|glycophagy|tertiary granule membrane|ficolin-1-rich granule membrane|glycogen binding|starch binding STC1 4442.730018 3312.677802 5572.782233 1.682259056 0.750399888 0.00177033 0.266035882 45.70618559 75.60300056 6781 stanniocalcin 1 "GO:0001503,GO:0001886,GO:0003421,GO:0005179,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0006874,GO:0007165,GO:0007566,GO:0010596,GO:0016324,GO:0030336,GO:0033280,GO:0035988,GO:0042802,GO:0044070,GO:0046697,GO:0051926,GO:0060348,GO:0071320,GO:0071385,GO:0071456,GO:0086004,GO:0090280,GO:1903403" ossification|endothelial cell morphogenesis|growth plate cartilage axis specification|hormone activity|protein binding|extracellular space|nucleus|cytoplasm|cellular calcium ion homeostasis|signal transduction|embryo implantation|negative regulation of endothelial cell migration|apical plasma membrane|negative regulation of cell migration|response to vitamin D|chondrocyte proliferation|identical protein binding|regulation of anion transport|decidualization|negative regulation of calcium ion transport|bone development|cellular response to cAMP|cellular response to glucocorticoid stimulus|cellular response to hypoxia|regulation of cardiac muscle cell contraction|positive regulation of calcium ion import|negative regulation of renal phosphate excretion STC2 6540.025153 7654.324935 5425.725372 0.708844401 -0.49645912 0.041673574 1 96.02662287 66.92890926 8614 stanniocalcin 2 "GO:0005179,GO:0005615,GO:0005783,GO:0005788,GO:0006874,GO:0007165,GO:0007566,GO:0010629,GO:0019899,GO:0020037,GO:0033280,GO:0042803,GO:0043434,GO:0043687,GO:0044267,GO:0046697,GO:0046885,GO:0048471,GO:0071456" hormone activity|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|cellular calcium ion homeostasis|signal transduction|embryo implantation|negative regulation of gene expression|enzyme binding|heme binding|response to vitamin D|protein homodimerization activity|response to peptide hormone|post-translational protein modification|cellular protein metabolic process|decidualization|regulation of hormone biosynthetic process|perinuclear region of cytoplasm|cellular response to hypoxia STEAP1 715.2894594 623.2079157 807.371003 1.295508261 0.373518215 0.143677766 1 27.28421744 34.75544609 26872 STEAP family member 1 "GO:0005215,GO:0005768,GO:0005886,GO:0005887,GO:0005911,GO:0006811,GO:0010008,GO:0015267,GO:0016020,GO:0016491,GO:0046872,GO:0055072,GO:0055085,GO:0055114" transporter activity|endosome|plasma membrane|integral component of plasma membrane|cell-cell junction|ion transport|endosome membrane|channel activity|membrane|oxidoreductase activity|metal ion binding|iron ion homeostasis|transmembrane transport|oxidation-reduction process hsa04978 Mineral absorption STEAP1B 248.6852988 233.0527097 264.3178879 1.134154965 0.181617776 0.59503137 1 7.783225773 8.679669837 256227 STEAP family member 1B "GO:0005515,GO:0005768,GO:0005886,GO:0016021" protein binding|endosome|plasma membrane|integral component of membrane STEAP2 561.0490805 560.7830827 561.3150783 1.000948665 0.001367986 1 1 3.306957177 3.254704426 261729 STEAP2 metalloreductase "GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0006893,GO:0006897,GO:0008823,GO:0009725,GO:0010008,GO:0015677,GO:0030140,GO:0030173,GO:0045055,GO:0046872,GO:0052851,GO:0055072,GO:0055114" endosome|early endosome|cytosol|plasma membrane|Golgi to plasma membrane transport|endocytosis|cupric reductase activity|response to hormone|endosome membrane|copper ion import|trans-Golgi network transport vesicle|integral component of Golgi membrane|regulated exocytosis|metal ion binding|ferric-chelate reductase (NADPH) activity|iron ion homeostasis|oxidation-reduction process hsa04978 Mineral absorption STEAP3 713.9993677 942.6149777 485.3837578 0.514933212 -0.957542772 0.000194063 0.058973703 10.31910337 5.224732316 55240 STEAP3 metalloreductase "GO:0005515,GO:0005737,GO:0005768,GO:0005771,GO:0005886,GO:0006915,GO:0007049,GO:0008823,GO:0009306,GO:0010008,GO:0015677,GO:0016021,GO:0033572,GO:0042981,GO:0046872,GO:0052851,GO:0055072,GO:0055114" protein binding|cytoplasm|endosome|multivesicular body|plasma membrane|apoptotic process|cell cycle|cupric reductase activity|protein secretion|endosome membrane|copper ion import|integral component of membrane|transferrin transport|regulation of apoptotic process|metal ion binding|ferric-chelate reductase (NADPH) activity|iron ion homeostasis|oxidation-reduction process "hsa04115,hsa04216" p53 signaling pathway|Ferroptosis STEAP4 6.926236509 5.202069413 8.650403604 1.662877389 0.733681797 0.660649523 1 0.027514855 0.044988201 79689 STEAP4 metalloreductase "GO:0000139,GO:0005654,GO:0005768,GO:0005886,GO:0008823,GO:0009055,GO:0015677,GO:0016021,GO:0020037,GO:0022900,GO:0031901,GO:0045444,GO:0046872,GO:0052851,GO:0055072,GO:0055114,GO:0070062,GO:0070207,GO:0071949" Golgi membrane|nucleoplasm|endosome|plasma membrane|cupric reductase activity|electron transfer activity|copper ion import|integral component of membrane|heme binding|electron transport chain|early endosome membrane|fat cell differentiation|metal ion binding|ferric-chelate reductase (NADPH) activity|iron ion homeostasis|oxidation-reduction process|extracellular exosome|protein homotrimerization|FAD binding STEEP1 722.9931839 686.6731625 759.3132052 1.105785469 0.145071519 0.572140258 1 15.2186398 16.54694774 63932 STING1 ER exit protein 1 STIL 1444.132024 1602.237379 1286.026669 0.802644281 -0.317167345 0.184653018 1 15.37922017 12.13748227 6491 STIL centriolar assembly protein "GO:0000578,GO:0001701,GO:0001843,GO:0001947,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0007052,GO:0007224,GO:0007368,GO:0021915,GO:0030900,GO:0030903,GO:0033504,GO:0035264,GO:0042802,GO:0043066,GO:0046599,GO:0051298,GO:0071539" embryonic axis specification|in utero embryonic development|neural tube closure|heart looping|protein binding|cytoplasm|centrosome|centriole|cytosol|mitotic spindle organization|smoothened signaling pathway|determination of left/right symmetry|neural tube development|forebrain development|notochord development|floor plate development|multicellular organism growth|identical protein binding|negative regulation of apoptotic process|regulation of centriole replication|centrosome duplication|protein localization to centrosome STIM1 1156.560767 1168.38479 1144.736744 0.979760053 -0.029499624 0.906908602 1 10.79358644 10.39816442 6786 stromal interaction molecule 1 "GO:0002020,GO:0002115,GO:0005246,GO:0005509,GO:0005513,GO:0005515,GO:0005783,GO:0005789,GO:0005874,GO:0005886,GO:0005887,GO:0006874,GO:0030176,GO:0032237,GO:0032541,GO:0033017,GO:0042802,GO:0044853,GO:0045762,GO:0045766,GO:0051010,GO:0051924,GO:0070166,GO:1903779,GO:2001256" protease binding|store-operated calcium entry|calcium channel regulator activity|calcium ion binding|detection of calcium ion|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|microtubule|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|integral component of endoplasmic reticulum membrane|activation of store-operated calcium channel activity|cortical endoplasmic reticulum|sarcoplasmic reticulum membrane|identical protein binding|plasma membrane raft|positive regulation of adenylate cyclase activity|positive regulation of angiogenesis|microtubule plus-end binding|regulation of calcium ion transport|enamel mineralization|regulation of cardiac conduction|regulation of store-operated calcium entry "hsa04020,hsa04611" Calcium signaling pathway|Platelet activation STIM2 362.1602235 385.9935505 338.3268965 0.876509196 -0.190158868 0.526471849 1 4.042340338 3.483858687 57620 stromal interaction molecule 2 "GO:0002115,GO:0005246,GO:0005509,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0006874,GO:0015279,GO:0016021,GO:0032237,GO:0051928,GO:0070588" store-operated calcium entry|calcium channel regulator activity|calcium ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|cellular calcium ion homeostasis|store-operated calcium channel activity|integral component of membrane|activation of store-operated calcium channel activity|positive regulation of calcium ion transport|calcium ion transmembrane transport hsa04020 Calcium signaling pathway STIMATE 539.4777917 524.3685969 554.5869866 1.057628145 0.080832475 0.769200895 1 5.898943564 6.134489387 375346 STIM activating enhancer "GO:0005246,GO:0005515,GO:0005789,GO:0016020,GO:0016021,GO:0032237,GO:0032541,GO:0035584,GO:0070886,GO:0140268" calcium channel regulator activity|protein binding|endoplasmic reticulum membrane|membrane|integral component of membrane|activation of store-operated calcium channel activity|cortical endoplasmic reticulum|calcium-mediated signaling using intracellular calcium source|positive regulation of calcineurin-NFAT signaling cascade|endoplasmic reticulum-plasma membrane contact site STING1 381.4525397 413.0443114 349.860768 0.847029624 -0.239515667 0.416016011 1 8.93893583 7.444843933 340061 stimulator of interferon response cGAMP interactor 1 "GO:0000045,GO:0000421,GO:0002218,GO:0002230,GO:0005515,GO:0005654,GO:0005741,GO:0005768,GO:0005776,GO:0005777,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0008134,GO:0016032,GO:0016239,GO:0019901,GO:0030176,GO:0030659,GO:0030667,GO:0031625,GO:0032092,GO:0032479,GO:0032481,GO:0032608,GO:0035438,GO:0035458,GO:0042802,GO:0042803,GO:0043312,GO:0045087,GO:0045944,GO:0048471,GO:0050727,GO:0051091,GO:0051259,GO:0051607,GO:0061507,GO:0061709,GO:0071360,GO:0071407,GO:1990701" autophagosome assembly|autophagosome membrane|activation of innate immune response|positive regulation of defense response to virus by host|protein binding|nucleoplasm|mitochondrial outer membrane|endosome|autophagosome|peroxisome|endoplasmic reticulum membrane|Golgi apparatus|cytosol|plasma membrane|transcription factor binding|viral process|positive regulation of macroautophagy|protein kinase binding|integral component of endoplasmic reticulum membrane|cytoplasmic vesicle membrane|secretory granule membrane|ubiquitin protein ligase binding|positive regulation of protein binding|regulation of type I interferon production|positive regulation of type I interferon production|interferon-beta production|cyclic-di-GMP binding|cellular response to interferon-beta|identical protein binding|protein homodimerization activity|neutrophil degranulation|innate immune response|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|regulation of inflammatory response|positive regulation of DNA-binding transcription factor activity|protein complex oligomerization|defense response to virus|cyclic-GMP-AMP binding|reticulophagy|cellular response to exogenous dsRNA|cellular response to organic cyclic compound|integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane "hsa04621,hsa04622,hsa04623,hsa05131,hsa05163,hsa05168,hsa05170,hsa05171" NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Shigellosis|Human cytomegalovirus infection|Herpes simplex virus 1 infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19 STIP1 6261.720583 6088.502041 6434.939125 1.056900216 0.079839176 0.742623976 1 114.2920027 118.7738976 10963 stress induced phosphoprotein 1 "GO:0003723,GO:0005515,GO:0005634,GO:0005794,GO:0005829,GO:0008022,GO:0030544,GO:0032991,GO:0051087,GO:0051879,GO:0098761,GO:0101031" RNA binding|protein binding|nucleus|Golgi apparatus|cytosol|protein C-terminus binding|Hsp70 protein binding|protein-containing complex|chaperone binding|Hsp90 protein binding|cellular response to interleukin-7|chaperone complex hsa05020 Prion disease STK10 1771.938468 1969.50348 1574.373456 0.799375818 -0.323054164 0.1731734 1 17.79393616 13.9860222 6793 serine/threonine kinase 10 "GO:0004674,GO:0005515,GO:0005524,GO:0005886,GO:0006468,GO:0007049,GO:0035579,GO:0042802,GO:0042803,GO:0043312,GO:0046777,GO:0070062,GO:0071593,GO:0106310,GO:0106311,GO:2000401" protein serine/threonine kinase activity|protein binding|ATP binding|plasma membrane|protein phosphorylation|cell cycle|specific granule membrane|identical protein binding|protein homodimerization activity|neutrophil degranulation|protein autophosphorylation|extracellular exosome|lymphocyte aggregation|protein serine kinase activity|protein threonine kinase activity|regulation of lymphocyte migration hsa04914 Progesterone-mediated oocyte maturation STK11 994.6172779 941.5745638 1047.659992 1.112668112 0.154023328 0.53287281 1 15.25967322 16.69483203 6794 serine/threonine kinase 11 "GO:0000287,GO:0001558,GO:0001894,GO:0001944,GO:0002039,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006468,GO:0006470,GO:0006914,GO:0006974,GO:0007050,GO:0007283,GO:0007409,GO:0008285,GO:0010212,GO:0010508,GO:0016020,GO:0030010,GO:0030275,GO:0030295,GO:0030308,GO:0030511,GO:0032147,GO:0042593,GO:0043276,GO:0045059,GO:0046777,GO:0048814,GO:0050772,GO:0050852,GO:0051645,GO:0051896,GO:0060070,GO:0060770,GO:0070062,GO:0071493,GO:0072332,GO:0090090,GO:0097484,GO:0106310,GO:0106311,GO:0120163,GO:1900182,GO:1901610,GO:1901796,GO:1904262" magnesium ion binding|regulation of cell growth|tissue homeostasis|vasculature development|p53 binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|protein phosphorylation|protein dephosphorylation|autophagy|cellular response to DNA damage stimulus|cell cycle arrest|spermatogenesis|axonogenesis|negative regulation of cell population proliferation|response to ionizing radiation|positive regulation of autophagy|membrane|establishment of cell polarity|LRR domain binding|protein kinase activator activity|negative regulation of cell growth|positive regulation of transforming growth factor beta receptor signaling pathway|activation of protein kinase activity|glucose homeostasis|anoikis|positive thymic T cell selection|protein autophosphorylation|regulation of dendrite morphogenesis|positive regulation of axonogenesis|T cell receptor signaling pathway|Golgi localization|regulation of protein kinase B signaling|canonical Wnt signaling pathway|negative regulation of epithelial cell proliferation involved in prostate gland development|extracellular exosome|cellular response to UV-B|intrinsic apoptotic signaling pathway by p53 class mediator|negative regulation of canonical Wnt signaling pathway|dendrite extension|protein serine kinase activity|protein threonine kinase activity|negative regulation of cold-induced thermogenesis|positive regulation of protein localization to nucleus|positive regulation of vesicle transport along microtubule|regulation of signal transduction by p53 class mediator|negative regulation of TORC1 signaling "hsa04068,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04530,hsa04920" FoxO signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Tight junction|Adipocytokine signaling pathway STK11IP 329.8923019 358.9427895 300.8418142 0.838133048 -0.254748815 0.40702692 1 4.155339906 3.424448969 114790 serine/threonine kinase 11 interacting protein "GO:0005576,GO:0005737,GO:0005765,GO:0008104,GO:0019901,GO:0035578,GO:0043312" extracellular region|cytoplasm|lysosomal membrane|protein localization|protein kinase binding|azurophil granule lumen|neutrophil degranulation STK16 719.5895091 685.6327487 753.5462695 1.099052329 0.136260079 0.596285561 1 11.69787713 12.64144167 8576 serine/threonine kinase 16 "GO:0004674,GO:0004715,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0018108,GO:0046777,GO:0048471,GO:0106310,GO:0106311" protein serine/threonine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|plasma membrane|peptidyl-tyrosine phosphorylation|protein autophosphorylation|perinuclear region of cytoplasm|protein serine kinase activity|protein threonine kinase activity STK17A 2170.121188 1711.480837 2628.76154 1.535957332 0.619138139 0.008984469 0.582287276 33.14172231 50.05245733 9263 serine/threonine kinase 17a "GO:0004674,GO:0005524,GO:0005634,GO:0005886,GO:0006468,GO:0006915,GO:0016607,GO:0035556,GO:0043065,GO:0106310,GO:0106311,GO:2000271,GO:2000377" protein serine/threonine kinase activity|ATP binding|nucleus|plasma membrane|protein phosphorylation|apoptotic process|nuclear speck|intracellular signal transduction|positive regulation of apoptotic process|protein serine kinase activity|protein threonine kinase activity|positive regulation of fibroblast apoptotic process|regulation of reactive oxygen species metabolic process STK17B 836.9688082 789.6741369 884.2634795 1.119782754 0.163218866 0.516270092 1 7.605749382 8.374270091 9262 serine/threonine kinase 17b "GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0005793,GO:0005886,GO:0006468,GO:0006915,GO:0015629,GO:0035556,GO:0043065,GO:0046777,GO:0106310,GO:0106311,GO:2000271" protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|endoplasmic reticulum-Golgi intermediate compartment|plasma membrane|protein phosphorylation|apoptotic process|actin cytoskeleton|intracellular signal transduction|positive regulation of apoptotic process|protein autophosphorylation|protein serine kinase activity|protein threonine kinase activity|positive regulation of fibroblast apoptotic process STK19 124.7515151 95.7180772 153.784953 1.60664482 0.684051029 0.114783245 1 3.153270283 4.981409616 8859 serine/threonine kinase 19 "GO:0004674,GO:0005524,GO:0005634,GO:0006468,GO:0016607,GO:0031267,GO:0046579,GO:0106310,GO:0106311" protein serine/threonine kinase activity|ATP binding|nucleus|protein phosphorylation|nuclear speck|small GTPase binding|positive regulation of Ras protein signal transduction|protein serine kinase activity|protein threonine kinase activity STK24 3294.353669 3002.634465 3586.072872 1.194308836 0.25617595 0.279969701 1 14.56376287 17.10257181 8428 serine/threonine kinase 24 "GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0006468,GO:0007165,GO:0008631,GO:0009267,GO:0016020,GO:0030336,GO:0042542,GO:0045296,GO:0046777,GO:0046872,GO:0048679,GO:0070062,GO:0097194,GO:0106310,GO:0106311" protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|Golgi apparatus|cytosol|protein phosphorylation|signal transduction|intrinsic apoptotic signaling pathway in response to oxidative stress|cellular response to starvation|membrane|negative regulation of cell migration|response to hydrogen peroxide|cadherin binding|protein autophosphorylation|metal ion binding|regulation of axon regeneration|extracellular exosome|execution phase of apoptosis|protein serine kinase activity|protein threonine kinase activity STK25 3057.648221 2756.056375 3359.240066 1.21885753 0.285529502 0.227969181 1 25.04864839 30.01984322 10494 serine/threonine kinase 25 "GO:0000139,GO:0004672,GO:0005515,GO:0005524,GO:0005737,GO:0005794,GO:0006468,GO:0006979,GO:0007163,GO:0007165,GO:0032874,GO:0036481,GO:0042542,GO:0042803,GO:0046777,GO:0046872,GO:0050772,GO:0051645,GO:0051683,GO:0070062,GO:0090168,GO:0106310,GO:0106311" Golgi membrane|protein kinase activity|protein binding|ATP binding|cytoplasm|Golgi apparatus|protein phosphorylation|response to oxidative stress|establishment or maintenance of cell polarity|signal transduction|positive regulation of stress-activated MAPK cascade|intrinsic apoptotic signaling pathway in response to hydrogen peroxide|response to hydrogen peroxide|protein homodimerization activity|protein autophosphorylation|metal ion binding|positive regulation of axonogenesis|Golgi localization|establishment of Golgi localization|extracellular exosome|Golgi reassembly|protein serine kinase activity|protein threonine kinase activity STK26 656.9514401 593.0359131 720.866967 1.215553647 0.281613566 0.277119735 1 9.197685768 10.99319363 51765 serine/threonine kinase 26 "GO:0000287,GO:0004672,GO:0005515,GO:0005524,GO:0005737,GO:0005794,GO:0005798,GO:0005829,GO:0006468,GO:0006915,GO:0009267,GO:0012506,GO:0016020,GO:0016324,GO:0030033,GO:0030336,GO:0042542,GO:0042802,GO:0042803,GO:0042981,GO:0046777,GO:0048471,GO:0070062,GO:0071944,GO:0106310,GO:0106311,GO:1903205" magnesium ion binding|protein kinase activity|protein binding|ATP binding|cytoplasm|Golgi apparatus|Golgi-associated vesicle|cytosol|protein phosphorylation|apoptotic process|cellular response to starvation|vesicle membrane|membrane|apical plasma membrane|microvillus assembly|negative regulation of cell migration|response to hydrogen peroxide|identical protein binding|protein homodimerization activity|regulation of apoptotic process|protein autophosphorylation|perinuclear region of cytoplasm|extracellular exosome|cell periphery|protein serine kinase activity|protein threonine kinase activity|regulation of hydrogen peroxide-induced cell death STK3 848.5573999 753.259651 943.8551488 1.253027621 0.325418217 0.193021719 1 4.457266121 5.491618856 6788 serine/threonine kinase 3 "GO:0000287,GO:0001841,GO:0003157,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0006915,GO:0007165,GO:0007417,GO:0008285,GO:0031098,GO:0032092,GO:0032147,GO:0032991,GO:0035329,GO:0035556,GO:0042802,GO:0043065,GO:0043539,GO:0045600,GO:0046330,GO:0046621,GO:0050821,GO:0051091,GO:0051897,GO:0060215,GO:0060706,GO:0060800,GO:0071902,GO:0090090,GO:0097284,GO:0106310,GO:0106311,GO:1902043" magnesium ion binding|neural tube formation|endocardium development|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|protein phosphorylation|apoptotic process|signal transduction|central nervous system development|negative regulation of cell population proliferation|stress-activated protein kinase signaling cascade|positive regulation of protein binding|activation of protein kinase activity|protein-containing complex|hippo signaling|intracellular signal transduction|identical protein binding|positive regulation of apoptotic process|protein serine/threonine kinase activator activity|positive regulation of fat cell differentiation|positive regulation of JNK cascade|negative regulation of organ growth|protein stabilization|positive regulation of DNA-binding transcription factor activity|positive regulation of protein kinase B signaling|primitive hemopoiesis|cell differentiation involved in embryonic placenta development|regulation of cell differentiation involved in embryonic placenta development|positive regulation of protein serine/threonine kinase activity|negative regulation of canonical Wnt signaling pathway|hepatocyte apoptotic process|protein serine kinase activity|protein threonine kinase activity|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors "hsa04010,hsa04390,hsa04392" MAPK signaling pathway|Hippo signaling pathway|Hippo signaling pathway - multiple species STK31 18.85639761 15.60620824 22.10658699 1.416525183 0.502356251 0.597410597 1 0.221509216 0.30852281 56164 serine/threonine kinase 31 "GO:0001669,GO:0004518,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0090305,GO:0106310,GO:0106311" acrosomal vesicle|nuclease activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|nucleic acid phosphodiester bond hydrolysis|protein serine kinase activity|protein threonine kinase activity STK32A 13.60966882 16.64662212 10.57271552 0.635126781 -0.654883491 0.544268462 1 0.147599207 0.092175527 202374 serine/threonine kinase 32A "GO:0004674,GO:0005524,GO:0005886,GO:0018105,GO:0035556,GO:0046872,GO:0106310,GO:0106311" protein serine/threonine kinase activity|ATP binding|plasma membrane|peptidyl-serine phosphorylation|intracellular signal transduction|metal ion binding|protein serine kinase activity|protein threonine kinase activity STK32C 281.5476549 275.7096789 287.3856308 1.04234872 0.059838015 0.863320964 1 2.529502979 2.592503857 282974 serine/threonine kinase 32C "GO:0004674,GO:0005515,GO:0005524,GO:0018105,GO:0035556,GO:0046872,GO:0106310,GO:0106311" protein serine/threonine kinase activity|protein binding|ATP binding|peptidyl-serine phosphorylation|intracellular signal transduction|metal ion binding|protein serine kinase activity|protein threonine kinase activity STK35 1048.2181 1099.717474 996.7187264 0.906340719 -0.141874592 0.563967343 1 5.711912447 5.090309775 140901 serine/threonine kinase 35 "GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006468,GO:0016604,GO:0051321,GO:0106310,GO:0106311" protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|protein phosphorylation|nuclear body|meiotic cell cycle|protein serine kinase activity|protein threonine kinase activity STK36 437.2882895 491.0753526 383.5012264 0.780941712 -0.356713223 0.206718696 1 5.065285854 3.88949984 27148 serine/threonine kinase 36 "GO:0003351,GO:0004674,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0007224,GO:0007228,GO:0007420,GO:0008134,GO:0009791,GO:0045880,GO:0046872,GO:0051090,GO:0060271,GO:0106310,GO:0106311" epithelial cilium movement involved in extracellular fluid movement|protein serine/threonine kinase activity|protein binding|ATP binding|extracellular region|nucleus|cytoplasm|cytosol|protein phosphorylation|smoothened signaling pathway|positive regulation of hh target transcription factor activity|brain development|transcription factor binding|post-embryonic development|positive regulation of smoothened signaling pathway|metal ion binding|regulation of DNA-binding transcription factor activity|cilium assembly|protein serine kinase activity|protein threonine kinase activity STK38 700.6633 743.8959261 657.4306739 0.883767004 -0.178262027 0.488467178 1 10.75307648 9.344190762 11329 serine/threonine kinase 38 "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0018105,GO:0031435,GO:0035556,GO:0043407,GO:0045296,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|cellular protein modification process|protein phosphorylation|peptidyl-serine phosphorylation|mitogen-activated protein kinase kinase kinase binding|intracellular signal transduction|negative regulation of MAP kinase activity|cadherin binding|protein serine kinase activity|protein threonine kinase activity STK38L 816.318432 853.1393838 779.4974803 0.913681275 -0.130237105 0.606469232 1 7.916967642 7.112540842 23012 serine/threonine kinase 38 like "GO:0000287,GO:0003779,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0015629,GO:0016020,GO:0018105,GO:0035556,GO:0051128,GO:0106310,GO:0106311" magnesium ion binding|actin binding|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytosol|protein phosphorylation|actin cytoskeleton|membrane|peptidyl-serine phosphorylation|intracellular signal transduction|regulation of cellular component organization|protein serine kinase activity|protein threonine kinase activity STK39 1841.709635 1454.498608 2228.920662 1.53243231 0.615823349 0.009509024 0.599243813 7.101264061 10.7001075 27347 serine/threonine kinase 39 "GO:0000187,GO:0004674,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0005856,GO:0006468,GO:0007165,GO:0008217,GO:0010820,GO:0016301,GO:0016323,GO:0016324,GO:0018105,GO:0018107,GO:0019898,GO:0019901,GO:0032414,GO:0035556,GO:0036438,GO:0038146,GO:0043231,GO:0043268,GO:0046777,GO:0050727,GO:0050801,GO:0071476,GO:0090188,GO:0106310,GO:0106311,GO:1901017,GO:1901380,GO:1905408,GO:1990869,GO:2000650" activation of MAPK activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleoplasm|cytosol|cytoskeleton|protein phosphorylation|signal transduction|regulation of blood pressure|positive regulation of T cell chemotaxis|kinase activity|basolateral plasma membrane|apical plasma membrane|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|extrinsic component of membrane|protein kinase binding|positive regulation of ion transmembrane transporter activity|intracellular signal transduction|maintenance of lens transparency|chemokine (C-X-C motif) ligand 12 signaling pathway|intracellular membrane-bounded organelle|positive regulation of potassium ion transport|protein autophosphorylation|regulation of inflammatory response|ion homeostasis|cellular hypotonic response|negative regulation of pancreatic juice secretion|protein serine kinase activity|protein threonine kinase activity|negative regulation of potassium ion transmembrane transporter activity|negative regulation of potassium ion transmembrane transport|negative regulation of creatine transmembrane transporter activity|cellular response to chemokine|negative regulation of sodium ion transmembrane transporter activity STK4 2437.352228 2532.36739 2342.337065 0.924959417 -0.112538027 0.634850019 1 18.29783284 16.64153997 6789 serine/threonine kinase 4 "GO:0000287,GO:0000902,GO:0001569,GO:0001841,GO:0001934,GO:0003157,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006915,GO:0007165,GO:0007417,GO:0008134,GO:0008285,GO:0016604,GO:0018105,GO:0030216,GO:0031098,GO:0032092,GO:0032147,GO:0032991,GO:0033138,GO:0035329,GO:0035556,GO:0042802,GO:0042803,GO:0043065,GO:0043539,GO:0045600,GO:0046621,GO:0046777,GO:0050821,GO:0060215,GO:0060706,GO:0060800,GO:0071902,GO:0090090,GO:0097284,GO:0106310,GO:0106311,GO:1902043,GO:1904237,GO:1905461" "magnesium ion binding|cell morphogenesis|branching involved in blood vessel morphogenesis|neural tube formation|positive regulation of protein phosphorylation|endocardium development|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|apoptotic process|signal transduction|central nervous system development|transcription factor binding|negative regulation of cell population proliferation|nuclear body|peptidyl-serine phosphorylation|keratinocyte differentiation|stress-activated protein kinase signaling cascade|positive regulation of protein binding|activation of protein kinase activity|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|hippo signaling|intracellular signal transduction|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|protein serine/threonine kinase activator activity|positive regulation of fat cell differentiation|negative regulation of organ growth|protein autophosphorylation|protein stabilization|primitive hemopoiesis|cell differentiation involved in embryonic placenta development|regulation of cell differentiation involved in embryonic placenta development|positive regulation of protein serine/threonine kinase activity|negative regulation of canonical Wnt signaling pathway|hepatocyte apoptotic process|protein serine kinase activity|protein threonine kinase activity|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of substrate-dependent cell migration, cell attachment to substrate|positive regulation of vascular associated smooth muscle cell apoptotic process" "hsa04010,hsa04014,hsa04068,hsa05200,hsa05223" MAPK signaling pathway|Ras signaling pathway|FoxO signaling pathway|Pathways in cancer|Non-small cell lung cancer STK40 569.6749464 522.2877691 617.0621237 1.181460031 0.240570823 0.36656989 1 7.180200493 8.341166372 83931 serine/threonine kinase 40 "GO:0003016,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0005977,GO:0006468,GO:0010468,GO:0035264,GO:0043066,GO:0043408,GO:0048286,GO:0060425,GO:0106310,GO:0106311" respiratory system process|protein binding|ATP binding|nucleoplasm|cytosol|glycogen metabolic process|protein phosphorylation|regulation of gene expression|multicellular organism growth|negative regulation of apoptotic process|regulation of MAPK cascade|lung alveolus development|lung morphogenesis|protein serine kinase activity|protein threonine kinase activity STKLD1 4.042768641 5.202069413 2.883467868 0.554292463 -0.851280704 0.745112452 1 0.09823952 0.053542221 169436 serine/threonine kinase like domain containing 1 "GO:0004674,GO:0005524,GO:0006468" protein serine/threonine kinase activity|ATP binding|protein phosphorylation STMN1 7243.960991 6339.241787 8148.680195 1.285434515 0.362256116 0.139443802 1 98.89321343 124.9935563 3925 stathmin 1 "GO:0000281,GO:0005515,GO:0005737,GO:0005829,GO:0005874,GO:0007019,GO:0007052,GO:0007165,GO:0007409,GO:0007420,GO:0009615,GO:0015631,GO:0016020,GO:0031110,GO:0031115,GO:0031175,GO:0035024,GO:0035556,GO:0043005,GO:0048012,GO:0051272,GO:0051497,GO:0061436,GO:0070062,GO:0070495,GO:1905098" mitotic cytokinesis|protein binding|cytoplasm|cytosol|microtubule|microtubule depolymerization|mitotic spindle organization|signal transduction|axonogenesis|brain development|response to virus|tubulin binding|membrane|regulation of microtubule polymerization or depolymerization|negative regulation of microtubule polymerization|neuron projection development|negative regulation of Rho protein signal transduction|intracellular signal transduction|neuron projection|hepatocyte growth factor receptor signaling pathway|positive regulation of cellular component movement|negative regulation of stress fiber assembly|establishment of skin barrier|extracellular exosome|negative regulation of thrombin-activated receptor signaling pathway|negative regulation of guanyl-nucleotide exchange factor activity "hsa04010,hsa05206" MAPK signaling pathway|MicroRNAs in cancer STMN3 4536.561726 4110.67525 4962.448201 1.207209983 0.271676642 0.255989333 1 89.83586528 106.6359769 50861 stathmin 3 "GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0007019,GO:0007399,GO:0015631,GO:0019904,GO:0030426,GO:0031110,GO:0031122,GO:0031175,GO:0035021,GO:0043005,GO:0043087,GO:0051493" protein binding|cytoplasm|Golgi apparatus|cytosol|microtubule depolymerization|nervous system development|tubulin binding|protein domain specific binding|growth cone|regulation of microtubule polymerization or depolymerization|cytoplasmic microtubule organization|neuron projection development|negative regulation of Rac protein signal transduction|neuron projection|regulation of GTPase activity|regulation of cytoskeleton organization STMP1 1166.524571 1089.313335 1243.735807 1.141761298 0.191261065 0.43152381 1 23.62236921 26.51978197 647087 short transmembrane mitochondrial protein 1 "GO:0005515,GO:0005741,GO:0005746,GO:0005758,GO:0016021,GO:0032731,GO:0045087,GO:1900227" protein binding|mitochondrial outer membrane|mitochondrial respirasome|mitochondrial intermembrane space|integral component of membrane|positive regulation of interleukin-1 beta production|innate immune response|positive regulation of NLRP3 inflammasome complex assembly STN1 1347.479172 1146.536099 1548.422245 1.350522017 0.43351716 0.071062134 1 9.607242007 12.75767629 79991 STN1 subunit of CST complex "GO:0000723,GO:0000781,GO:0001650,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0010833,GO:0016233,GO:0032211,GO:0042162,GO:0043047,GO:0043231,GO:0045111,GO:0045740,GO:1990879" "telomere maintenance|chromosome, telomeric region|fibrillar center|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|telomere maintenance via telomere lengthening|telomere capping|negative regulation of telomere maintenance via telomerase|telomeric DNA binding|single-stranded telomeric DNA binding|intracellular membrane-bounded organelle|intermediate filament cytoskeleton|positive regulation of DNA replication|CST complex" STOM 1674.13699 1382.71005 1965.56393 1.421530081 0.507444629 0.032864839 0.920517339 23.46349573 32.79592988 2040 stomatin "GO:0005515,GO:0005615,GO:0005739,GO:0005783,GO:0005856,GO:0005886,GO:0005887,GO:0016020,GO:0031982,GO:0035577,GO:0035579,GO:0042470,GO:0042802,GO:0042803,GO:0043312,GO:0044829,GO:0045121,GO:0048471,GO:0070062,GO:0070063,GO:0070821,GO:0072562,GO:0090314,GO:1901585" protein binding|extracellular space|mitochondrion|endoplasmic reticulum|cytoskeleton|plasma membrane|integral component of plasma membrane|membrane|vesicle|azurophil granule membrane|specific granule membrane|melanosome|identical protein binding|protein homodimerization activity|neutrophil degranulation|positive regulation by host of viral genome replication|membrane raft|perinuclear region of cytoplasm|extracellular exosome|RNA polymerase binding|tertiary granule membrane|blood microparticle|positive regulation of protein targeting to membrane|regulation of acid-sensing ion channel activity STOML1 120.4212829 108.2030438 132.6395219 1.225839101 0.293769629 0.510910849 1 0.76171977 0.918120906 9399 stomatin like 1 "GO:0003674,GO:0005515,GO:0005575,GO:0005886,GO:0006869,GO:0008150,GO:0016021,GO:0031902,GO:0045121" molecular_function|protein binding|cellular_component|plasma membrane|lipid transport|biological_process|integral component of membrane|late endosome membrane|membrane raft STOML2 2352.004305 2247.293987 2456.714624 1.093187913 0.128541414 0.587340751 1 85.54489993 91.95177615 30968 stomatin like 2 "GO:0001772,GO:0005102,GO:0005515,GO:0005743,GO:0005758,GO:0005856,GO:0006851,GO:0006874,GO:0007005,GO:0008180,GO:0010876,GO:0010918,GO:0015629,GO:0019897,GO:0032623,GO:0034982,GO:0035710,GO:0042101,GO:0042776,GO:0045121,GO:0050852,GO:0051020,GO:0051259,GO:0090297,GO:1900210,GO:1901612,GO:1990046" "immunological synapse|signaling receptor binding|protein binding|mitochondrial inner membrane|mitochondrial intermembrane space|cytoskeleton|mitochondrial calcium ion transmembrane transport|cellular calcium ion homeostasis|mitochondrion organization|COP9 signalosome|lipid localization|positive regulation of mitochondrial membrane potential|actin cytoskeleton|extrinsic component of plasma membrane|interleukin-2 production|mitochondrial protein processing|CD4-positive, alpha-beta T cell activation|T cell receptor complex|mitochondrial ATP synthesis coupled proton transport|membrane raft|T cell receptor signaling pathway|GTPase binding|protein complex oligomerization|positive regulation of mitochondrial DNA replication|positive regulation of cardiolipin metabolic process|cardiolipin binding|stress-induced mitochondrial fusion" STON1 206.3101484 243.4568485 169.1634483 0.694839555 -0.525248211 0.143500133 1 2.301247707 1.572240867 11037 stonin 1 "GO:0008021,GO:0016020,GO:0016192,GO:0030100,GO:0030136,GO:0031410,GO:0035615,GO:0043231,GO:0048488" synaptic vesicle|membrane|vesicle-mediated transport|regulation of endocytosis|clathrin-coated vesicle|cytoplasmic vesicle|clathrin adaptor activity|intracellular membrane-bounded organelle|synaptic vesicle endocytosis STON2 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.028859136 0.017476359 85439 stonin 2 "GO:0005515,GO:0005730,GO:0005829,GO:0008021,GO:0016020,GO:0016192,GO:0030100,GO:0030136,GO:0031410,GO:0035615,GO:0043005,GO:0043231,GO:0048488,GO:0061024" protein binding|nucleolus|cytosol|synaptic vesicle|membrane|vesicle-mediated transport|regulation of endocytosis|clathrin-coated vesicle|cytoplasmic vesicle|clathrin adaptor activity|neuron projection|intracellular membrane-bounded organelle|synaptic vesicle endocytosis|membrane organization STOX1 16.09181664 18.72744989 13.45618338 0.718527267 -0.476885189 0.64781365 1 0.156237233 0.110382181 219736 storkhead box 1 "GO:0000977,GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0007049,GO:0008284,GO:0010468,GO:0010628,GO:0010629,GO:0010800,GO:0010821,GO:0010971,GO:0033138,GO:0051301,GO:0051881,GO:0061418,GO:0071500,GO:1901858,GO:1902882,GO:1904031" RNA polymerase II transcription regulatory region sequence-specific DNA binding|fibrillar center|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|cell cycle|positive regulation of cell population proliferation|regulation of gene expression|positive regulation of gene expression|negative regulation of gene expression|positive regulation of peptidyl-threonine phosphorylation|regulation of mitochondrion organization|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of peptidyl-serine phosphorylation|cell division|regulation of mitochondrial membrane potential|regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to nitrosative stress|regulation of mitochondrial DNA metabolic process|regulation of response to oxidative stress|positive regulation of cyclin-dependent protein kinase activity STOX2 14.05061783 15.60620824 12.49502743 0.800644669 -0.320765987 0.805610112 1 0.043272959 0.034066506 56977 storkhead box 2 "GO:0001893,GO:0003674,GO:0005575,GO:0006357,GO:0009792" maternal placenta development|molecular_function|cellular_component|regulation of transcription by RNA polymerase II|embryo development ending in birth or egg hatching STPG1 365.2323897 315.2454064 415.219373 1.317130605 0.397398409 0.180717873 1 5.427118692 7.028608277 90529 sperm tail PG-rich repeat containing 1 "GO:0003674,GO:0005634,GO:0005739,GO:0043065,GO:1902110" molecular_function|nucleus|mitochondrion|positive regulation of apoptotic process|positive regulation of mitochondrial membrane permeability involved in apoptotic process STRA6 3.641448589 7.282897178 0 0 #NAME? 0.060320757 1 0.074061516 0 64220 signaling receptor and transporter of retinol STRA6 "GO:0001523,GO:0001568,GO:0001822,GO:0003184,GO:0003281,GO:0005886,GO:0005887,GO:0007507,GO:0007612,GO:0007631,GO:0016918,GO:0019841,GO:0030324,GO:0030325,GO:0030540,GO:0032991,GO:0034632,GO:0034633,GO:0038023,GO:0042297,GO:0043010,GO:0043583,GO:0043585,GO:0048286,GO:0048520,GO:0048546,GO:0048566,GO:0048589,GO:0048745,GO:0048844,GO:0050890,GO:0050905,GO:0060322,GO:0060323,GO:0060325,GO:0060426,GO:0060539,GO:0060900,GO:0061029,GO:0061038,GO:0061143,GO:0061156,GO:0061205,GO:0071939,GO:0097070" retinoid metabolic process|blood vessel development|kidney development|pulmonary valve morphogenesis|ventricular septum development|plasma membrane|integral component of plasma membrane|heart development|learning|feeding behavior|retinal binding|retinol binding|lung development|adrenal gland development|female genitalia development|protein-containing complex|retinol transmembrane transporter activity|retinol transport|signaling receptor activity|vocal learning|camera-type eye development|ear development|nose morphogenesis|lung alveolus development|positive regulation of behavior|digestive tract morphogenesis|embryonic digestive tract development|developmental growth|smooth muscle tissue development|artery morphogenesis|cognition|neuromuscular process|head development|head morphogenesis|face morphogenesis|lung vasculature development|diaphragm development|embryonic camera-type eye formation|eyelid development in camera-type eye|uterus morphogenesis|alveolar primary septum development|pulmonary artery morphogenesis|paramesonephric duct development|vitamin A import|ductus arteriosus closure STRADA 711.0825301 727.249304 694.9157562 0.95553994 -0.065611918 0.802140394 1 14.97952865 14.07402023 92335 STE20 related adaptor alpha "GO:0004672,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006611,GO:0007050,GO:0019900,GO:0030295,GO:0032147,GO:0043539,GO:0071902" protein kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|protein export from nucleus|cell cycle arrest|kinase binding|protein kinase activator activity|activation of protein kinase activity|protein serine/threonine kinase activator activity|positive regulation of protein serine/threonine kinase activity "hsa04150,hsa04152" mTOR signaling pathway|AMPK signaling pathway STRADB 970.1323387 980.0698774 960.1948 0.979720755 -0.029557492 0.908814374 1 23.22581175 22.37403889 55437 STE20 related adaptor beta "GO:0000902,GO:0004672,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0006611,GO:0007050,GO:0007254,GO:0016235,GO:0032147,GO:2001240" cell morphogenesis|protein kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|protein phosphorylation|protein export from nucleus|cell cycle arrest|JNK cascade|aggresome|activation of protein kinase activity|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand "hsa04150,hsa04152" mTOR signaling pathway|AMPK signaling pathway STRAP 2879.567641 2622.883398 3136.251884 1.195726766 0.257887759 0.275860599 1 74.49625668 87.58658234 11171 serine/threonine kinase receptor associated protein "GO:0000122,GO:0000387,GO:0003723,GO:0005102,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0010633,GO:0010719,GO:0030277,GO:0030512,GO:0032797,GO:0034719,GO:0050680,GO:0060394" negative regulation of transcription by RNA polymerase II|spliceosomal snRNP assembly|RNA binding|signaling receptor binding|protein binding|nucleus|cytoplasm|cytosol|negative regulation of epithelial cell migration|negative regulation of epithelial to mesenchymal transition|maintenance of gastrointestinal epithelium|negative regulation of transforming growth factor beta receptor signaling pathway|SMN complex|SMN-Sm protein complex|negative regulation of epithelial cell proliferation|negative regulation of pathway-restricted SMAD protein phosphorylation hsa03013 RNA transport STRBP 811.53719 891.6346974 731.4396825 0.820335598 -0.285713861 0.255586464 1 4.879502158 3.935847392 55342 spermatid perinuclear RNA binding protein "GO:0002177,GO:0003677,GO:0003723,GO:0003725,GO:0003727,GO:0005515,GO:0005634,GO:0005737,GO:0007275,GO:0007286,GO:0007638,GO:0008017" manchette|DNA binding|RNA binding|double-stranded RNA binding|single-stranded RNA binding|protein binding|nucleus|cytoplasm|multicellular organism development|spermatid development|mechanosensory behavior|microtubule binding STRIP1 871.1829651 956.1403581 786.225572 0.822290959 -0.282279128 0.257499778 1 15.29599928 12.36729011 85369 striatin interacting protein 1 "GO:0003674,GO:0005515,GO:0005634,GO:0005829,GO:0007010,GO:0019901,GO:0022604,GO:0030866,GO:0031267,GO:0070062" molecular_function|protein binding|nucleus|cytosol|cytoskeleton organization|protein kinase binding|regulation of cell morphogenesis|cortical actin cytoskeleton organization|small GTPase binding|extracellular exosome STRIP2 784.4813986 850.0181421 718.9446551 0.845799189 -0.241612918 0.33881586 1 8.183998914 6.806189018 57464 striatin interacting protein 2 "GO:0003674,GO:0005737,GO:0005829,GO:0007010,GO:0008360,GO:0016477" molecular_function|cytoplasm|cytosol|cytoskeleton organization|regulation of cell shape|cell migration STRN 1327.966746 1466.983575 1188.949918 0.810472549 -0.303164772 0.207109729 1 5.462616325 4.3532157 6801 striatin "GO:0005515,GO:0005516,GO:0005737,GO:0005923,GO:0007626,GO:0008285,GO:0014069,GO:0016020,GO:0016055,GO:0016358,GO:0030331,GO:0030425,GO:0043025,GO:0043197,GO:0044877,GO:0045211,GO:0051721,GO:0070016,GO:0070830,GO:0090443" protein binding|calmodulin binding|cytoplasm|bicellular tight junction|locomotory behavior|negative regulation of cell population proliferation|postsynaptic density|membrane|Wnt signaling pathway|dendrite development|estrogen receptor binding|dendrite|neuronal cell body|dendritic spine|protein-containing complex binding|postsynaptic membrane|protein phosphatase 2A binding|armadillo repeat domain binding|bicellular tight junction assembly|FAR/SIN/STRIPAK complex STRN3 755.9794573 719.9664068 791.9925077 1.100040919 0.13755719 0.590051536 1 9.11152096 9.855323791 29966 striatin 3 "GO:0005515,GO:0005516,GO:0005654,GO:0005794,GO:0005886,GO:0030425,GO:0031267,GO:0032355,GO:0032991,GO:0033147,GO:0043025,GO:0044877,GO:0045892,GO:0051721,GO:0070016,GO:0090443" "protein binding|calmodulin binding|nucleoplasm|Golgi apparatus|plasma membrane|dendrite|small GTPase binding|response to estradiol|protein-containing complex|negative regulation of intracellular estrogen receptor signaling pathway|neuronal cell body|protein-containing complex binding|negative regulation of transcription, DNA-templated|protein phosphatase 2A binding|armadillo repeat domain binding|FAR/SIN/STRIPAK complex" STRN4 1229.766521 1273.466592 1186.06645 0.931368327 -0.102576273 0.673311716 1 17.89430529 16.38730308 29888 striatin 4 "GO:0005515,GO:0005516,GO:0005737,GO:0008150,GO:0016020,GO:0030425,GO:0043197,GO:0044877,GO:0051721,GO:0070016,GO:0090443" protein binding|calmodulin binding|cytoplasm|biological_process|membrane|dendrite|dendritic spine|protein-containing complex binding|protein phosphatase 2A binding|armadillo repeat domain binding|FAR/SIN/STRIPAK complex STS 126.4756822 90.51600779 162.4353566 1.794548396 0.843620831 0.050852634 1 0.630307016 1.112188743 412 steroid sulfatase "GO:0004065,GO:0004773,GO:0005764,GO:0005768,GO:0005783,GO:0005788,GO:0005789,GO:0005794,GO:0005886,GO:0006687,GO:0006706,GO:0007565,GO:0008484,GO:0008544,GO:0016020,GO:0016021,GO:0043231,GO:0046872" arylsulfatase activity|steryl-sulfatase activity|lysosome|endosome|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|glycosphingolipid metabolic process|steroid catabolic process|female pregnancy|sulfuric ester hydrolase activity|epidermis development|membrane|integral component of membrane|intracellular membrane-bounded organelle|metal ion binding hsa00140 Steroid hormone biosynthesis STT3A 4927.301305 4931.561804 4923.040807 0.99827215 -0.002494916 0.992660321 1 84.9817209 83.41528835 3703 STT3 oligosaccharyltransferase complex catalytic subunit A "GO:0004579,GO:0005515,GO:0005789,GO:0006487,GO:0008250,GO:0016020,GO:0016021,GO:0018279,GO:0035000,GO:0043686,GO:0043687,GO:0046872" dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding|endoplasmic reticulum membrane|protein N-linked glycosylation|oligosaccharyltransferase complex|membrane|integral component of membrane|protein N-linked glycosylation via asparagine|oligosaccharyltransferase III complex|co-translational protein modification|post-translational protein modification|metal ion binding "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum STT3B 4394.791222 4110.67525 4678.907194 1.138233236 0.186796212 0.434332999 1 33.69879923 37.7152393 201595 STT3 oligosaccharyltransferase complex catalytic subunit B "GO:0004579,GO:0005515,GO:0005783,GO:0006487,GO:0006516,GO:0006986,GO:0008250,GO:0016020,GO:0016021,GO:0018279,GO:0030433,GO:0032991,GO:0034998,GO:0043686,GO:0043687,GO:0046872" dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding|endoplasmic reticulum|protein N-linked glycosylation|glycoprotein catabolic process|response to unfolded protein|oligosaccharyltransferase complex|membrane|integral component of membrane|protein N-linked glycosylation via asparagine|ubiquitin-dependent ERAD pathway|protein-containing complex|oligosaccharyltransferase I complex|co-translational protein modification|post-translational protein modification|metal ion binding "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum STUB1 1003.153825 925.9683556 1080.339295 1.166712975 0.222449684 0.366141311 1 34.58168599 39.67175097 10273 STIP1 homology and U-box containing protein 1 "GO:0000151,GO:0000209,GO:0001664,GO:0002931,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0006281,GO:0006511,GO:0006515,GO:0016567,GO:0019899,GO:0019900,GO:0030018,GO:0030433,GO:0030512,GO:0030544,GO:0030579,GO:0030674,GO:0030911,GO:0030968,GO:0031072,GO:0031371,GO:0031398,GO:0031625,GO:0031647,GO:0031943,GO:0032091,GO:0032436,GO:0034450,GO:0034605,GO:0038128,GO:0042405,GO:0042803,GO:0043161,GO:0045862,GO:0046332,GO:0048156,GO:0051087,GO:0051443,GO:0051604,GO:0051787,GO:0051865,GO:0051879,GO:0061630,GO:0061684,GO:0070534,GO:0071218,GO:0071456,GO:0090035,GO:0101031" ubiquitin ligase complex|protein polyubiquitination|G protein-coupled receptor binding|response to ischemia|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|DNA repair|ubiquitin-dependent protein catabolic process|protein quality control for misfolded or incompletely synthesized proteins|protein ubiquitination|enzyme binding|kinase binding|Z disc|ubiquitin-dependent ERAD pathway|negative regulation of transforming growth factor beta receptor signaling pathway|Hsp70 protein binding|ubiquitin-dependent SMAD protein catabolic process|protein-macromolecule adaptor activity|TPR domain binding|endoplasmic reticulum unfolded protein response|heat shock protein binding|ubiquitin conjugating enzyme complex|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|regulation of protein stability|regulation of glucocorticoid metabolic process|negative regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|ubiquitin-ubiquitin ligase activity|cellular response to heat|ERBB2 signaling pathway|nuclear inclusion body|protein homodimerization activity|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of proteolysis|SMAD binding|tau protein binding|chaperone binding|positive regulation of ubiquitin-protein transferase activity|protein maturation|misfolded protein binding|protein autoubiquitination|Hsp90 protein binding|ubiquitin protein ligase activity|chaperone-mediated autophagy|protein K63-linked ubiquitination|cellular response to misfolded protein|cellular response to hypoxia|positive regulation of chaperone-mediated protein complex assembly|chaperone complex "hsa04120,hsa04141" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum STX10 717.5036509 693.9560597 741.0512421 1.06786479 0.094728989 0.714551306 1 25.79050102 27.07991051 8677 syntaxin 10 "GO:0000149,GO:0005484,GO:0005515,GO:0005802,GO:0005829,GO:0006886,GO:0006906,GO:0012505,GO:0016021,GO:0019905,GO:0030285,GO:0031201,GO:0031982,GO:0032588,GO:0032880,GO:0034498,GO:0042147,GO:0048278,GO:0048471" "SNARE binding|SNAP receptor activity|protein binding|trans-Golgi network|cytosol|intracellular protein transport|vesicle fusion|endomembrane system|integral component of membrane|syntaxin binding|integral component of synaptic vesicle membrane|SNARE complex|vesicle|trans-Golgi network membrane|regulation of protein localization|early endosome to Golgi transport|retrograde transport, endosome to Golgi|vesicle docking|perinuclear region of cytoplasm" hsa05132 Salmonella infection STX11 121.5359243 124.8496659 118.2221826 0.946916291 -0.0786912 0.875434041 1 1.35261819 1.259383476 8676 syntaxin 11 "GO:0000149,GO:0005484,GO:0005515,GO:0005794,GO:0005886,GO:0006886,GO:0006887,GO:0006906,GO:0008021,GO:0012505,GO:0016021,GO:0031201,GO:0031629,GO:0048278,GO:0048787,GO:0061025" SNARE binding|SNAP receptor activity|protein binding|Golgi apparatus|plasma membrane|intracellular protein transport|exocytosis|vesicle fusion|synaptic vesicle|endomembrane system|integral component of membrane|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|vesicle docking|presynaptic active zone membrane|membrane fusion hsa04130 SNARE interactions in vesicular transport STX12 862.4495019 764.7042037 960.1948 1.25564211 0.328425318 0.188132603 1 13.45117267 16.60722992 23673 syntaxin 12 "GO:0000045,GO:0000139,GO:0000149,GO:0000407,GO:0005484,GO:0005515,GO:0005654,GO:0005794,GO:0006886,GO:0006906,GO:0008021,GO:0012505,GO:0016021,GO:0030285,GO:0031083,GO:0031201,GO:0031901,GO:0031982,GO:0033344,GO:0043231,GO:0045121,GO:0045335,GO:0048278,GO:0050821,GO:0055038,GO:0098837" autophagosome assembly|Golgi membrane|SNARE binding|phagophore assembly site|SNAP receptor activity|protein binding|nucleoplasm|Golgi apparatus|intracellular protein transport|vesicle fusion|synaptic vesicle|endomembrane system|integral component of membrane|integral component of synaptic vesicle membrane|BLOC-1 complex|SNARE complex|early endosome membrane|vesicle|cholesterol efflux|intracellular membrane-bounded organelle|membrane raft|phagocytic vesicle|vesicle docking|protein stabilization|recycling endosome membrane|postsynaptic recycling endosome hsa04145 Phagosome STX16 5592.426987 5613.032897 5571.821077 0.992657834 -0.010631584 0.965650472 1 69.68068141 68.01162349 8675 syntaxin 16 "GO:0000139,GO:0000149,GO:0005484,GO:0005515,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0005925,GO:0006886,GO:0006906,GO:0012505,GO:0016021,GO:0019905,GO:0030285,GO:0031201,GO:0031985,GO:0032588,GO:0042147,GO:0043231,GO:0048278,GO:0048471,GO:0090161" "Golgi membrane|SNARE binding|SNAP receptor activity|protein binding|cytoplasm|Golgi apparatus|trans-Golgi network|cytosol|focal adhesion|intracellular protein transport|vesicle fusion|endomembrane system|integral component of membrane|syntaxin binding|integral component of synaptic vesicle membrane|SNARE complex|Golgi cisterna|trans-Golgi network membrane|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|vesicle docking|perinuclear region of cytoplasm|Golgi ribbon formation" hsa04130 SNARE interactions in vesicular transport STX17 838.1023425 958.2211859 717.9834991 0.749287857 -0.416408023 0.095993976 1 6.657792417 4.905125498 55014 syntaxin 17 "GO:0000149,GO:0000421,GO:0005484,GO:0005515,GO:0005739,GO:0005765,GO:0005776,GO:0005789,GO:0005791,GO:0005793,GO:0005829,GO:0005886,GO:0006886,GO:0006887,GO:0006888,GO:0006906,GO:0007030,GO:0012505,GO:0012507,GO:0016021,GO:0016240,GO:0019901,GO:0019903,GO:0030134,GO:0030868,GO:0030897,GO:0031201,GO:0033116,GO:0034497,GO:0044233,GO:0048278,GO:0097111,GO:0097352" SNARE binding|autophagosome membrane|SNAP receptor activity|protein binding|mitochondrion|lysosomal membrane|autophagosome|endoplasmic reticulum membrane|rough endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cytosol|plasma membrane|intracellular protein transport|exocytosis|endoplasmic reticulum to Golgi vesicle-mediated transport|vesicle fusion|Golgi organization|endomembrane system|ER to Golgi transport vesicle membrane|integral component of membrane|autophagosome membrane docking|protein kinase binding|protein phosphatase binding|COPII-coated ER to Golgi transport vesicle|smooth endoplasmic reticulum membrane|HOPS complex|SNARE complex|endoplasmic reticulum-Golgi intermediate compartment membrane|protein localization to phagophore assembly site|mitochondria-associated endoplasmic reticulum membrane|vesicle docking|endoplasmic reticulum-Golgi intermediate compartment organization|autophagosome maturation "hsa04130,hsa04140" SNARE interactions in vesicular transport|Autophagy - animal STX18 655.8462451 652.3395044 659.3529858 1.010751275 0.015428023 0.958953005 1 14.1406013 14.05346297 53407 syntaxin 18 "GO:0000139,GO:0005484,GO:0005515,GO:0005783,GO:0005789,GO:0006886,GO:0006890,GO:0016021,GO:0019904,GO:0031201,GO:0061025,GO:0090158,GO:1902117,GO:1902953,GO:1903358" "Golgi membrane|SNAP receptor activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|integral component of membrane|protein domain specific binding|SNARE complex|membrane fusion|endoplasmic reticulum membrane organization|positive regulation of organelle assembly|positive regulation of ER to Golgi vesicle-mediated transport|regulation of Golgi organization" "hsa04130,hsa04145" SNARE interactions in vesicular transport|Phagosome STX1A 797.5563836 802.1591035 792.9536637 0.988524172 -0.016651851 0.952662252 1 15.48833468 15.05439117 6804 syntaxin 1A "GO:0000149,GO:0001956,GO:0005484,GO:0005515,GO:0005576,GO:0005829,GO:0005886,GO:0006886,GO:0006887,GO:0006906,GO:0007269,GO:0008021,GO:0008076,GO:0009629,GO:0010701,GO:0010807,GO:0012505,GO:0014047,GO:0014069,GO:0016021,GO:0016079,GO:0016081,GO:0016925,GO:0017156,GO:0019221,GO:0019855,GO:0019869,GO:0019900,GO:0019904,GO:0030073,GO:0030141,GO:0030285,GO:0030424,GO:0031201,GO:0031629,GO:0031965,GO:0032028,GO:0032940,GO:0033605,GO:0035493,GO:0042641,GO:0042802,GO:0043005,GO:0043008,GO:0044325,GO:0044877,GO:0045956,GO:0047485,GO:0048278,GO:0048306,GO:0048488,GO:0048787,GO:0050796,GO:0070032,GO:0070033,GO:0070044,GO:0072657,GO:0098978,GO:0099056,GO:2000463" SNARE binding|positive regulation of neurotransmitter secretion|SNAP receptor activity|protein binding|extracellular region|cytosol|plasma membrane|intracellular protein transport|exocytosis|vesicle fusion|neurotransmitter secretion|synaptic vesicle|voltage-gated potassium channel complex|response to gravity|positive regulation of norepinephrine secretion|regulation of synaptic vesicle priming|endomembrane system|glutamate secretion|postsynaptic density|integral component of membrane|synaptic vesicle exocytosis|synaptic vesicle docking|protein sumoylation|calcium-ion regulated exocytosis|cytokine-mediated signaling pathway|calcium channel inhibitor activity|chloride channel inhibitor activity|kinase binding|protein domain specific binding|insulin secretion|secretory granule|integral component of synaptic vesicle membrane|axon|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|nuclear membrane|myosin head/neck binding|secretion by cell|positive regulation of catecholamine secretion|SNARE complex assembly|actomyosin|identical protein binding|neuron projection|ATP-dependent protein binding|ion channel binding|protein-containing complex binding|positive regulation of calcium ion-dependent exocytosis|protein N-terminus binding|vesicle docking|calcium-dependent protein binding|synaptic vesicle endocytosis|presynaptic active zone membrane|regulation of insulin secretion|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex|synaptobrevin 2-SNAP-25-syntaxin-1a complex|protein localization to membrane|glutamatergic synapse|integral component of presynaptic membrane|positive regulation of excitatory postsynaptic potential "hsa04130,hsa04721,hsa04911,hsa05016,hsa05022,hsa05031" SNARE interactions in vesicular transport|Synaptic vesicle cycle|Insulin secretion|Huntington disease|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction STX1B 104.5622096 108.2030438 100.9213754 0.932703664 -0.10050931 0.846520847 1 1.228376426 1.126539268 112755 syntaxin 1B "GO:0000149,GO:0001956,GO:0005102,GO:0005484,GO:0005515,GO:0005634,GO:0005815,GO:0005819,GO:0005829,GO:0005886,GO:0006886,GO:0006887,GO:0006904,GO:0006906,GO:0008021,GO:0010468,GO:0010807,GO:0010977,GO:0012505,GO:0016020,GO:0016021,GO:0016081,GO:0017157,GO:0019901,GO:0019904,GO:0030424,GO:0031201,GO:0031594,GO:0031629,GO:0048278,GO:0048787,GO:0048791,GO:0060025,GO:0061669,GO:0098967,GO:1903422,GO:1904050,GO:1905302,GO:2000463" SNARE binding|positive regulation of neurotransmitter secretion|signaling receptor binding|SNAP receptor activity|protein binding|nucleus|microtubule organizing center|spindle|cytosol|plasma membrane|intracellular protein transport|exocytosis|vesicle docking involved in exocytosis|vesicle fusion|synaptic vesicle|regulation of gene expression|regulation of synaptic vesicle priming|negative regulation of neuron projection development|endomembrane system|membrane|integral component of membrane|synaptic vesicle docking|regulation of exocytosis|protein kinase binding|protein domain specific binding|axon|SNARE complex|neuromuscular junction|synaptic vesicle fusion to presynaptic active zone membrane|vesicle docking|presynaptic active zone membrane|calcium ion-regulated exocytosis of neurotransmitter|regulation of synaptic activity|spontaneous neurotransmitter secretion|exocytic insertion of neurotransmitter receptor to postsynaptic membrane|negative regulation of synaptic vesicle recycling|positive regulation of spontaneous neurotransmitter secretion|negative regulation of macropinocytosis|positive regulation of excitatory postsynaptic potential "hsa04130,hsa04721" SNARE interactions in vesicular transport|Synaptic vesicle cycle STX2 1364.22959 1220.405484 1508.053695 1.235698884 0.305327229 0.203211301 1 7.102595168 8.629803254 2054 syntaxin 2 "GO:0000149,GO:0005198,GO:0005484,GO:0005515,GO:0005615,GO:0005886,GO:0006886,GO:0006887,GO:0006906,GO:0007165,GO:0007340,GO:0007398,GO:0008021,GO:0009887,GO:0012505,GO:0016021,GO:0016323,GO:0030027,GO:0030154,GO:0031201,GO:0031629,GO:0032991,GO:0034599,GO:0043231,GO:0048278,GO:0048306,GO:0048787,GO:1903575" SNARE binding|structural molecule activity|SNAP receptor activity|protein binding|extracellular space|plasma membrane|intracellular protein transport|exocytosis|vesicle fusion|signal transduction|acrosome reaction|ectoderm development|synaptic vesicle|animal organ morphogenesis|endomembrane system|integral component of membrane|basolateral plasma membrane|lamellipodium|cell differentiation|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|protein-containing complex|cellular response to oxidative stress|intracellular membrane-bounded organelle|vesicle docking|calcium-dependent protein binding|presynaptic active zone membrane|cornified envelope assembly "hsa04130,hsa04721" SNARE interactions in vesicular transport|Synaptic vesicle cycle STX3 967.0853246 988.3931885 945.7774607 0.956883831 -0.063584308 0.800054058 1 8.391461642 7.895288578 6809 syntaxin 3 "GO:0000149,GO:0005484,GO:0005515,GO:0005773,GO:0005886,GO:0005911,GO:0006886,GO:0006887,GO:0006906,GO:0008021,GO:0008284,GO:0012505,GO:0016021,GO:0016081,GO:0016324,GO:0019221,GO:0030027,GO:0030425,GO:0030426,GO:0031175,GO:0031201,GO:0031629,GO:0042470,GO:0042581,GO:0042582,GO:0042589,GO:0043005,GO:0045785,GO:0048278,GO:0048787,GO:0050544,GO:0050921,GO:0060291,GO:0070062,GO:0098685,GO:0098794,GO:0098967,GO:0098978,GO:1903078,GO:2000010" SNARE binding|SNAP receptor activity|protein binding|vacuole|plasma membrane|cell-cell junction|intracellular protein transport|exocytosis|vesicle fusion|synaptic vesicle|positive regulation of cell population proliferation|endomembrane system|integral component of membrane|synaptic vesicle docking|apical plasma membrane|cytokine-mediated signaling pathway|lamellipodium|dendrite|growth cone|neuron projection development|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|melanosome|specific granule|azurophil granule|zymogen granule membrane|neuron projection|positive regulation of cell adhesion|vesicle docking|presynaptic active zone membrane|arachidonic acid binding|positive regulation of chemotaxis|long-term synaptic potentiation|extracellular exosome|Schaffer collateral - CA1 synapse|postsynapse|exocytic insertion of neurotransmitter receptor to postsynaptic membrane|glutamatergic synapse|positive regulation of protein localization to plasma membrane|positive regulation of protein localization to cell surface "hsa04130,hsa04721" SNARE interactions in vesicular transport|Synaptic vesicle cycle STX4 879.7893237 866.6647642 892.9138831 1.030287511 0.043046991 0.867094232 1 25.46933128 25.80163079 6810 syntaxin 4 "GO:0000149,GO:0000322,GO:0002639,GO:0005484,GO:0005515,GO:0005615,GO:0005768,GO:0005773,GO:0005802,GO:0005829,GO:0005886,GO:0006886,GO:0006887,GO:0006892,GO:0006906,GO:0008021,GO:0008284,GO:0009986,GO:0012505,GO:0016020,GO:0016021,GO:0016230,GO:0016323,GO:0017157,GO:0019221,GO:0030027,GO:0030335,GO:0030670,GO:0031201,GO:0031629,GO:0034599,GO:0035493,GO:0035749,GO:0035774,GO:0036477,GO:0042581,GO:0043085,GO:0043197,GO:0043219,GO:0043311,GO:0045202,GO:0045785,GO:0048278,GO:0048284,GO:0048471,GO:0048787,GO:0050921,GO:0060291,GO:0070062,GO:0071346,GO:0098794,GO:0098978,GO:1902041,GO:1903078,GO:1903575,GO:1990668,GO:2000010" SNARE binding|storage vacuole|positive regulation of immunoglobulin production|SNAP receptor activity|protein binding|extracellular space|endosome|vacuole|trans-Golgi network|cytosol|plasma membrane|intracellular protein transport|exocytosis|post-Golgi vesicle-mediated transport|vesicle fusion|synaptic vesicle|positive regulation of cell population proliferation|cell surface|endomembrane system|membrane|integral component of membrane|sphingomyelin phosphodiesterase activator activity|basolateral plasma membrane|regulation of exocytosis|cytokine-mediated signaling pathway|lamellipodium|positive regulation of cell migration|phagocytic vesicle membrane|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|cellular response to oxidative stress|SNARE complex assembly|myelin sheath adaxonal region|positive regulation of insulin secretion involved in cellular response to glucose stimulus|somatodendritic compartment|specific granule|positive regulation of catalytic activity|dendritic spine|lateral loop|positive regulation of eosinophil degranulation|synapse|positive regulation of cell adhesion|vesicle docking|organelle fusion|perinuclear region of cytoplasm|presynaptic active zone membrane|positive regulation of chemotaxis|long-term synaptic potentiation|extracellular exosome|cellular response to interferon-gamma|postsynapse|glutamatergic synapse|regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of protein localization to plasma membrane|cornified envelope assembly|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane|positive regulation of protein localization to cell surface "hsa04130,hsa04962" SNARE interactions in vesicular transport|Vasopressin-regulated water reabsorption STX5 890.0544539 934.2916666 845.8172413 0.905303206 -0.143527031 0.565815878 1 27.21693728 24.22727057 6811 syntaxin 5 "GO:0000139,GO:0000149,GO:0005484,GO:0005515,GO:0005789,GO:0005794,GO:0005829,GO:0006886,GO:0006888,GO:0006906,GO:0012505,GO:0012507,GO:0016021,GO:0031201,GO:0031982,GO:0033116,GO:0034498,GO:0042147,GO:0045296,GO:0045732,GO:0047485,GO:0048208,GO:0048278,GO:0048280,GO:0090166,GO:1903358" "Golgi membrane|SNARE binding|SNAP receptor activity|protein binding|endoplasmic reticulum membrane|Golgi apparatus|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|vesicle fusion|endomembrane system|ER to Golgi transport vesicle membrane|integral component of membrane|SNARE complex|vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|early endosome to Golgi transport|retrograde transport, endosome to Golgi|cadherin binding|positive regulation of protein catabolic process|protein N-terminus binding|COPII vesicle coating|vesicle docking|vesicle fusion with Golgi apparatus|Golgi disassembly|regulation of Golgi organization" hsa04130 SNARE interactions in vesicular transport STX6 1171.017735 1169.425204 1172.610266 1.002723613 0.003924002 0.991118932 1 12.65667691 12.47877961 10228 syntaxin 6 "GO:0000139,GO:0000149,GO:0005484,GO:0005515,GO:0005654,GO:0005769,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0006886,GO:0006906,GO:0007032,GO:0012505,GO:0016021,GO:0016189,GO:0019905,GO:0030136,GO:0030285,GO:0031201,GO:0032456,GO:0032588,GO:0032880,GO:0042147,GO:0045335,GO:0048193,GO:0048278,GO:0048471,GO:0090161,GO:1903827" "Golgi membrane|SNARE binding|SNAP receptor activity|protein binding|nucleoplasm|early endosome|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|intracellular protein transport|vesicle fusion|endosome organization|endomembrane system|integral component of membrane|synaptic vesicle to endosome fusion|syntaxin binding|clathrin-coated vesicle|integral component of synaptic vesicle membrane|SNARE complex|endocytic recycling|trans-Golgi network membrane|regulation of protein localization|retrograde transport, endosome to Golgi|phagocytic vesicle|Golgi vesicle transport|vesicle docking|perinuclear region of cytoplasm|Golgi ribbon formation|regulation of cellular protein localization" hsa04130 SNARE interactions in vesicular transport STX7 1709.707978 1660.500557 1758.915399 1.059268178 0.083067887 0.728172741 1 5.356171825 5.578681984 8417 syntaxin 7 "GO:0000149,GO:0001772,GO:0001916,GO:0005484,GO:0005515,GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005886,GO:0006886,GO:0006906,GO:0008021,GO:0012505,GO:0016021,GO:0019869,GO:0019905,GO:0030139,GO:0031201,GO:0031901,GO:0031982,GO:0042582,GO:0048278,GO:0048471,GO:0051640,GO:0055037,GO:0070062,GO:0070820,GO:0070925,GO:1902685,GO:1903076" SNARE binding|immunological synapse|positive regulation of T cell mediated cytotoxicity|SNAP receptor activity|protein binding|lysosome|lysosomal membrane|endosome|early endosome|late endosome|plasma membrane|intracellular protein transport|vesicle fusion|synaptic vesicle|endomembrane system|integral component of membrane|chloride channel inhibitor activity|syntaxin binding|endocytic vesicle|SNARE complex|early endosome membrane|vesicle|azurophil granule|vesicle docking|perinuclear region of cytoplasm|organelle localization|recycling endosome|extracellular exosome|tertiary granule|organelle assembly|positive regulation of receptor localization to synapse|regulation of protein localization to plasma membrane "hsa04130,hsa04145" SNARE interactions in vesicular transport|Phagosome STX8 383.1471387 381.8318949 384.4623824 1.006889125 0.009904827 0.983115004 1 16.04540666 15.88559759 9482 syntaxin 8 "GO:0000149,GO:0005484,GO:0005515,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005783,GO:0005802,GO:0005829,GO:0005887,GO:0006886,GO:0006906,GO:0008333,GO:0012505,GO:0016021,GO:0019869,GO:0019905,GO:0031201,GO:0031625,GO:0031902,GO:0031982,GO:0045022,GO:0045335,GO:0048278,GO:0048471,GO:0055037,GO:0071346,GO:1903076" SNARE binding|SNAP receptor activity|protein binding|lysosomal membrane|endosome|early endosome|late endosome|endoplasmic reticulum|trans-Golgi network|cytosol|integral component of plasma membrane|intracellular protein transport|vesicle fusion|endosome to lysosome transport|endomembrane system|integral component of membrane|chloride channel inhibitor activity|syntaxin binding|SNARE complex|ubiquitin protein ligase binding|late endosome membrane|vesicle|early endosome to late endosome transport|phagocytic vesicle|vesicle docking|perinuclear region of cytoplasm|recycling endosome|cellular response to interferon-gamma|regulation of protein localization to plasma membrane hsa04130 SNARE interactions in vesicular transport STXBP1 2582.611309 2422.083519 2743.139098 1.132553472 0.179579167 0.44786199 1 23.86231231 26.57311211 6812 syntaxin binding protein 1 "GO:0000149,GO:0002576,GO:0003006,GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005856,GO:0005886,GO:0006886,GO:0006904,GO:0007269,GO:0007274,GO:0007412,GO:0010807,GO:0014047,GO:0016082,GO:0016188,GO:0016192,GO:0017075,GO:0019901,GO:0019904,GO:0019905,GO:0030141,GO:0030424,GO:0031091,GO:0031333,GO:0031630,GO:0032229,GO:0032355,GO:0032991,GO:0035493,GO:0035542,GO:0042802,GO:0043274,GO:0043306,GO:0043524,GO:0045335,GO:0045956,GO:0047485,GO:0048471,GO:0048787,GO:0050821,GO:0060292,GO:0070062,GO:0070527,GO:0071346,GO:0072659,GO:0098794,GO:0098978,GO:0099525,GO:0106022,GO:1903296,GO:2000367" "SNARE binding|platelet degranulation|developmental process involved in reproduction|RNA binding|protein binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|cytoskeleton|plasma membrane|intracellular protein transport|vesicle docking involved in exocytosis|neurotransmitter secretion|neuromuscular synaptic transmission|axon target recognition|regulation of synaptic vesicle priming|glutamate secretion|synaptic vesicle priming|synaptic vesicle maturation|vesicle-mediated transport|syntaxin-1 binding|protein kinase binding|protein domain specific binding|syntaxin binding|secretory granule|axon|platelet alpha granule|negative regulation of protein-containing complex assembly|regulation of synaptic vesicle fusion to presynaptic active zone membrane|negative regulation of synaptic transmission, GABAergic|response to estradiol|protein-containing complex|SNARE complex assembly|regulation of SNARE complex assembly|identical protein binding|phospholipase binding|positive regulation of mast cell degranulation|negative regulation of neuron apoptotic process|phagocytic vesicle|positive regulation of calcium ion-dependent exocytosis|protein N-terminus binding|perinuclear region of cytoplasm|presynaptic active zone membrane|protein stabilization|long-term synaptic depression|extracellular exosome|platelet aggregation|cellular response to interferon-gamma|protein localization to plasma membrane|postsynapse|glutamatergic synapse|presynaptic dense core vesicle exocytosis|positive regulation of vesicle docking|positive regulation of glutamate secretion, neurotransmission|regulation of acrosomal vesicle exocytosis" hsa04721 Synaptic vesicle cycle STXBP2 1547.605973 1429.528675 1665.683272 1.165197524 0.22057454 0.355060832 1 28.62713621 32.79809625 6813 syntaxin binding protein 2 "GO:0001909,GO:0002576,GO:0005515,GO:0005576,GO:0005829,GO:0005886,GO:0006886,GO:0006904,GO:0007269,GO:0016192,GO:0017075,GO:0019905,GO:0030141,GO:0030348,GO:0042581,GO:0042582,GO:0043304,GO:0043312,GO:0044194,GO:0070062,GO:0070820,GO:0098793" leukocyte mediated cytotoxicity|platelet degranulation|protein binding|extracellular region|cytosol|plasma membrane|intracellular protein transport|vesicle docking involved in exocytosis|neurotransmitter secretion|vesicle-mediated transport|syntaxin-1 binding|syntaxin binding|secretory granule|syntaxin-3 binding|specific granule|azurophil granule|regulation of mast cell degranulation|neutrophil degranulation|cytolytic granule|extracellular exosome|tertiary granule|presynapse STXBP3 1146.92467 1129.889477 1163.959863 1.030153733 0.042859652 0.863396879 1 24.22664713 24.53954654 6814 syntaxin binding protein 3 "GO:0001678,GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0006904,GO:0007269,GO:0007420,GO:0016192,GO:0016323,GO:0016324,GO:0017075,GO:0019905,GO:0022615,GO:0030073,GO:0030141,GO:0031091,GO:0032868,GO:0042581,GO:0043312,GO:0044877,GO:0045335,GO:0045955,GO:0046325,GO:0070062,GO:0070527,GO:0070820,GO:0071346,GO:0098793" cellular glucose homeostasis|protein binding|cytosol|plasma membrane|intracellular protein transport|vesicle docking involved in exocytosis|neurotransmitter secretion|brain development|vesicle-mediated transport|basolateral plasma membrane|apical plasma membrane|syntaxin-1 binding|syntaxin binding|protein to membrane docking|insulin secretion|secretory granule|platelet alpha granule|response to insulin|specific granule|neutrophil degranulation|protein-containing complex binding|phagocytic vesicle|negative regulation of calcium ion-dependent exocytosis|negative regulation of glucose import|extracellular exosome|platelet aggregation|tertiary granule|cellular response to interferon-gamma|presynapse STXBP4 203.6694847 237.2143652 170.1246042 0.717176652 -0.479599574 0.184065886 1 1.533393252 1.081311617 252983 syntaxin binding protein 4 "GO:0005515,GO:0006605,GO:0006974,GO:0008286,GO:0010827,GO:0010838,GO:0019905,GO:0045335,GO:0050821,GO:0061178,GO:0070062,GO:0071346,GO:1902808" protein binding|protein targeting|cellular response to DNA damage stimulus|insulin receptor signaling pathway|regulation of glucose transmembrane transport|positive regulation of keratinocyte proliferation|syntaxin binding|phagocytic vesicle|protein stabilization|regulation of insulin secretion involved in cellular response to glucose stimulus|extracellular exosome|cellular response to interferon-gamma|positive regulation of cell cycle G1/S phase transition STXBP5 671.5807867 762.623376 580.5381974 0.761238399 -0.393579759 0.126756932 1 3.716198679 2.781575101 134957 syntaxin binding protein 5 "GO:0005096,GO:0005737,GO:0005829,GO:0005886,GO:0005892,GO:0006887,GO:0008021,GO:0010807,GO:0015031,GO:0017075,GO:0017157,GO:0019905,GO:0031201,GO:0031594,GO:0043547,GO:0045159,GO:0045921,GO:0050708,GO:0098674,GO:0098685,GO:0098686,GO:0098888,GO:0099504,GO:0099523,GO:2000300" GTPase activator activity|cytoplasm|cytosol|plasma membrane|acetylcholine-gated channel complex|exocytosis|synaptic vesicle|regulation of synaptic vesicle priming|protein transport|syntaxin-1 binding|regulation of exocytosis|syntaxin binding|SNARE complex|neuromuscular junction|positive regulation of GTPase activity|myosin II binding|positive regulation of exocytosis|regulation of protein secretion|extrinsic component of neuronal dense core vesicle membrane|Schaffer collateral - CA1 synapse|hippocampal mossy fiber to CA3 synapse|extrinsic component of presynaptic membrane|synaptic vesicle cycle|presynaptic cytosol|regulation of synaptic vesicle exocytosis STXBP6 179.651261 111.3242854 247.9782366 2.227530459 1.155445159 0.002506162 0.320296819 0.666573826 1.459967157 29091 syntaxin binding protein 6 "GO:0000145,GO:0005546,GO:0005886,GO:0005912,GO:0006887,GO:0006893,GO:0016021,GO:0035542,GO:0045920,GO:0051601,GO:0098609,GO:0098641" "exocyst|phosphatidylinositol-4,5-bisphosphate binding|plasma membrane|adherens junction|exocytosis|Golgi to plasma membrane transport|integral component of membrane|regulation of SNARE complex assembly|negative regulation of exocytosis|exocyst localization|cell-cell adhesion|cadherin binding involved in cell-cell adhesion" STYK1 411.120041 333.9728563 488.2672256 1.461996735 0.54794009 0.05633273 1 5.396160317 7.757154211 55359 serine/threonine/tyrosine kinase 1 "GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005886,GO:0007169,GO:0016021,GO:0030154,GO:0031234,GO:0038083,GO:0042127,GO:0045087" non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|protein binding|ATP binding|plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|integral component of membrane|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|peptidyl-tyrosine autophosphorylation|regulation of cell population proliferation|innate immune response STYX 532.0609164 544.1364606 519.9853722 0.955615751 -0.065497462 0.814127532 1 6.172064362 5.799424835 6815 serine/threonine/tyrosine interacting protein "GO:0001691,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006470,GO:0008138,GO:0032091,GO:0043086,GO:0045204,GO:0062026,GO:0070372,GO:1990444" pseudophosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|negative regulation of protein binding|negative regulation of catalytic activity|MAPK export from nucleus|negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process|regulation of ERK1 and ERK2 cascade|F-box domain binding STYXL1 900.4994505 754.3000649 1046.698836 1.387642511 0.472635944 0.057069166 1 14.91500857 20.35036869 51657 serine/threonine/tyrosine interacting like 1 "GO:0001691,GO:0004864,GO:0005515,GO:0005739,GO:0005759,GO:0006470,GO:0008138,GO:0010976,GO:0019903,GO:0032515,GO:0035556,GO:0062030,GO:2001242,GO:2001244" pseudophosphatase activity|protein phosphatase inhibitor activity|protein binding|mitochondrion|mitochondrial matrix|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|positive regulation of neuron projection development|protein phosphatase binding|negative regulation of phosphoprotein phosphatase activity|intracellular signal transduction|negative regulation of stress granule assembly|regulation of intrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway SUB1 2524.680254 2276.425575 2772.934933 1.218109199 0.284643471 0.228634809 1 30.04170353 35.98172311 10923 SUB1 regulator of transcription "GO:0000978,GO:0003697,GO:0003713,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0006357,GO:0042802,GO:0051053,GO:0060261,GO:0060395,GO:0070062" RNA polymerase II cis-regulatory region sequence-specific DNA binding|single-stranded DNA binding|transcription coactivator activity|RNA binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|regulation of transcription by RNA polymerase II|identical protein binding|negative regulation of DNA metabolic process|positive regulation of transcription initiation from RNA polymerase II promoter|SMAD protein signal transduction|extracellular exosome SUCLA2 793.7520031 702.2793708 885.2246355 1.26050212 0.333998544 0.184971848 1 17.75431515 22.00486374 8803 succinate-CoA ligase ADP-forming subunit beta "GO:0000287,GO:0004775,GO:0004776,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0006099,GO:0006104,GO:0006781,GO:0042709,GO:0070062" magnesium ion binding|succinate-CoA ligase (ADP-forming) activity|succinate-CoA ligase (GDP-forming) activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|tricarboxylic acid cycle|succinyl-CoA metabolic process|succinyl-CoA pathway|succinate-CoA ligase complex|extracellular exosome "hsa00020,hsa00640" Citrate cycle (TCA cycle)|Propanoate metabolism SUCLG1 1494.044166 1373.346325 1614.742006 1.175771891 0.233608194 0.32807333 1 57.71099942 66.7195099 8802 succinate-CoA ligase GDP/ADP-forming subunit alpha "GO:0000166,GO:0003723,GO:0004775,GO:0004776,GO:0005515,GO:0005739,GO:0005759,GO:0006099,GO:0009361" nucleotide binding|RNA binding|succinate-CoA ligase (ADP-forming) activity|succinate-CoA ligase (GDP-forming) activity|protein binding|mitochondrion|mitochondrial matrix|tricarboxylic acid cycle|succinate-CoA ligase complex (ADP-forming) "hsa00020,hsa00640" Citrate cycle (TCA cycle)|Propanoate metabolism SUCLG2 1592.319847 1379.588808 1805.050885 1.308397745 0.387801178 0.10333969 1 22.28393436 28.66835911 8801 succinate-CoA ligase GDP-forming subunit beta "GO:0000287,GO:0004775,GO:0004776,GO:0005515,GO:0005524,GO:0005525,GO:0005739,GO:0005759,GO:0005886,GO:0006099,GO:0006104,GO:0006105,GO:0019003,GO:0042709,GO:0044877,GO:0045244" magnesium ion binding|succinate-CoA ligase (ADP-forming) activity|succinate-CoA ligase (GDP-forming) activity|protein binding|ATP binding|GTP binding|mitochondrion|mitochondrial matrix|plasma membrane|tricarboxylic acid cycle|succinyl-CoA metabolic process|succinate metabolic process|GDP binding|succinate-CoA ligase complex|protein-containing complex binding|succinate-CoA ligase complex (GDP-forming) "hsa00020,hsa00640" Citrate cycle (TCA cycle)|Propanoate metabolism SUCNR1 4.042768641 5.202069413 2.883467868 0.554292463 -0.851280704 0.745112452 1 0.066401551 0.036189983 56670 succinate receptor 1 "GO:0002001,GO:0002281,GO:0004930,GO:0005515,GO:0005886,GO:0007186,GO:0016021,GO:0042593,GO:0050729,GO:0050921,GO:0051592,GO:0060177,GO:0070062" renin secretion into blood stream|macrophage activation involved in immune response|G protein-coupled receptor activity|protein binding|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|glucose homeostasis|positive regulation of inflammatory response|positive regulation of chemotaxis|response to calcium ion|regulation of angiotensin metabolic process|extracellular exosome hsa04024 cAMP signaling pathway SUCO 1177.711228 1155.899824 1199.522633 1.037739265 0.053444008 0.828678924 1 11.89515024 12.13750326 51430 SUN domain containing ossification factor "GO:0001503,GO:0005737,GO:0005791,GO:0007275,GO:0016020,GO:0016021,GO:0030867,GO:0032967,GO:0045669,GO:0046850" ossification|cytoplasm|rough endoplasmic reticulum|multicellular organism development|membrane|integral component of membrane|rough endoplasmic reticulum membrane|positive regulation of collagen biosynthetic process|positive regulation of osteoblast differentiation|regulation of bone remodeling SUDS3 1512.979821 1391.033361 1634.926281 1.175332186 0.233068566 0.328898081 1 11.34426862 13.11016959 64426 "SDS3 homolog, SIN3A corepressor complex component" "GO:0000122,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006915,GO:0016575,GO:0016579,GO:0016580,GO:0016604,GO:0019899,GO:0021762,GO:0042826,GO:0043065,GO:0045892,GO:0070822" "negative regulation of transcription by RNA polymerase II|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytosol|apoptotic process|histone deacetylation|protein deubiquitination|Sin3 complex|nuclear body|enzyme binding|substantia nigra development|histone deacetylase binding|positive regulation of apoptotic process|negative regulation of transcription, DNA-templated|Sin3-type complex" SUFU 1042.589559 1153.818996 931.3601214 0.807197771 -0.309005905 0.207081448 1 9.836613287 7.807225626 51684 SUFU negative regulator of hedgehog signaling "GO:0000122,GO:0001501,GO:0001843,GO:0001947,GO:0003281,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006508,GO:0007165,GO:0007275,GO:0008013,GO:0008134,GO:0019901,GO:0021775,GO:0021776,GO:0035904,GO:0042308,GO:0042994,GO:0043433,GO:0043588,GO:0045668,GO:0045879,GO:0060976,GO:0097542,GO:0097546,GO:1901621,GO:2000059" "negative regulation of transcription by RNA polymerase II|skeletal system development|neural tube closure|heart looping|ventricular septum development|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|proteolysis|signal transduction|multicellular organism development|beta-catenin binding|transcription factor binding|protein kinase binding|smoothened signaling pathway involved in ventral spinal cord interneuron specification|smoothened signaling pathway involved in spinal cord motor neuron cell fate specification|aorta development|negative regulation of protein import into nucleus|cytoplasmic sequestering of transcription factor|negative regulation of DNA-binding transcription factor activity|skin development|negative regulation of osteoblast differentiation|negative regulation of smoothened signaling pathway|coronary vasculature development|ciliary tip|ciliary base|negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|negative regulation of ubiquitin-dependent protein catabolic process" "hsa04340,hsa05200,hsa05217" Hedgehog signaling pathway|Pathways in cancer|Basal cell carcinoma SUGCT 15.85404286 12.48496659 19.22311912 1.539701286 0.622650484 0.53684871 1 0.084331062 0.12767187 79783 succinyl-CoA:glutarate-CoA transferase "GO:0005739,GO:0047369" mitochondrion|succinate-hydroxymethylglutarate CoA-transferase activity SUGP1 378.7376485 392.2360338 365.2392633 0.931172131 -0.102880215 0.732834406 1 7.980524675 7.306890392 57794 SURP and G-patch domain containing 1 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005681" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|spliceosomal complex" SUGP2 2065.021223 2043.372866 2086.66958 1.021188847 0.030249686 0.900265878 1 14.39427855 14.45330422 10147 SURP and G-patch domain containing 2 "GO:0003723,GO:0005654,GO:0006397,GO:0008380,GO:0016604" RNA binding|nucleoplasm|mRNA processing|RNA splicing|nuclear body SUGT1 1045.300648 985.2719469 1105.329349 1.121852046 0.16588242 0.499561917 1 3.626855632 4.00070963 10910 "SGT1 homolog, MIS12 kinetochore complex assembly cochaperone" "GO:0000151,GO:0000278,GO:0000776,GO:0005515,GO:0005634,GO:0005829,GO:0031647,GO:0032991,GO:0043947,GO:0050821" ubiquitin ligase complex|mitotic cell cycle|kinetochore|protein binding|nucleus|cytosol|regulation of protein stability|protein-containing complex|positive regulation by host of symbiont catalytic activity|protein stabilization hsa04621 NOD-like receptor signaling pathway SULT1A3 3.443303773 2.080827765 4.80577978 2.309551929 1.207612985 0.648665767 1 0.081955685 0.186113551 6818 sulfotransferase family 1A member 3 "GO:0004062,GO:0005515,GO:0005737,GO:0005829,GO:0006068,GO:0006805,GO:0007212,GO:0008146,GO:0008202,GO:0009812,GO:0036498,GO:0042420,GO:0043199,GO:0047685,GO:0050427,GO:0051923,GO:0070371,GO:0097720,GO:0098989,GO:1901215,GO:1903351" aryl sulfotransferase activity|protein binding|cytoplasm|cytosol|ethanol catabolic process|xenobiotic metabolic process|dopamine receptor signaling pathway|sulfotransferase activity|steroid metabolic process|flavonoid metabolic process|IRE1-mediated unfolded protein response|dopamine catabolic process|sulfate binding|amine sulfotransferase activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|ERK1 and ERK2 cascade|calcineurin-mediated signaling|NMDA selective glutamate receptor signaling pathway|negative regulation of neuron death|cellular response to dopamine hsa05204 Chemical carcinogenesis SULT1A4 3.403674809 1.040413883 5.766935736 5.54292463 2.470647391 0.304382079 1 0.040947623 0.223171559 445329 sulfotransferase family 1A member 4 "GO:0004062,GO:0005515,GO:0005737,GO:0005829,GO:0006068,GO:0006584,GO:0006805,GO:0007212,GO:0008146,GO:0008202,GO:0009812,GO:0036498,GO:0042420,GO:0043199,GO:0047685,GO:0050427,GO:0051923,GO:0070371,GO:0097720,GO:0098989,GO:1901215,GO:1903351" aryl sulfotransferase activity|protein binding|cytoplasm|cytosol|ethanol catabolic process|catecholamine metabolic process|xenobiotic metabolic process|dopamine receptor signaling pathway|sulfotransferase activity|steroid metabolic process|flavonoid metabolic process|IRE1-mediated unfolded protein response|dopamine catabolic process|sulfate binding|amine sulfotransferase activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|ERK1 and ERK2 cascade|calcineurin-mediated signaling|NMDA selective glutamate receptor signaling pathway|negative regulation of neuron death|cellular response to dopamine hsa05204 Chemical carcinogenesis SULT1C2 15.76975451 22.88910542 8.650403604 0.377926679 -1.403821727 0.139520198 1 0.491173899 0.182521492 6819 sulfotransferase family 1C member 2 "GO:0004062,GO:0005515,GO:0005737,GO:0005829,GO:0008146,GO:0009308,GO:0050427,GO:0051923" aryl sulfotransferase activity|protein binding|cytoplasm|cytosol|sulfotransferase activity|amine metabolic process|3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation SULT2B1 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.118558669 0.035898059 6820 sulfotransferase family 2B member 1 "GO:0003676,GO:0004027,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0008146,GO:0008202,GO:0008203,GO:0008285,GO:0015485,GO:0043231,GO:0045606,GO:0050294,GO:0050427,GO:0051923,GO:0070062,GO:1990239" nucleic acid binding|alcohol sulfotransferase activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum|cytosol|sulfotransferase activity|steroid metabolic process|cholesterol metabolic process|negative regulation of cell population proliferation|cholesterol binding|intracellular membrane-bounded organelle|positive regulation of epidermal cell differentiation|steroid sulfotransferase activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|extracellular exosome|steroid hormone binding hsa00140 Steroid hormone biosynthesis SUMF1 376.2460542 314.2049926 438.2871159 1.394908185 0.480170165 0.102647378 1 2.341648229 3.211725764 285362 sulfatase modifying factor 1 "GO:0005783,GO:0005788,GO:0006687,GO:0016491,GO:0018158,GO:0042802,GO:0043687,GO:0120147,GO:1903135" endoplasmic reticulum|endoplasmic reticulum lumen|glycosphingolipid metabolic process|oxidoreductase activity|protein oxidation|identical protein binding|post-translational protein modification|Formylglycine-generating oxidase activity|cupric ion binding hsa04142 Lysosome SUMF2 3325.871213 3401.112982 3250.629443 0.955754619 -0.065287827 0.783982979 1 78.33886443 73.61983778 25870 sulfatase modifying factor 2 "GO:0005515,GO:0005783,GO:0005788,GO:0006687,GO:0043687,GO:0046872" protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|glycosphingolipid metabolic process|post-translational protein modification|metal ion binding SUMO1 3111.094943 2998.47281 3223.717076 1.075119663 0.104497243 0.659783695 1 95.87955836 101.3570608 7341 small ubiquitin like modifier 1 "GO:0000122,GO:0003723,GO:0005515,GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0006281,GO:0006303,GO:0008076,GO:0008134,GO:0015459,GO:0016032,GO:0016604,GO:0016605,GO:0016607,GO:0016925,GO:0019899,GO:0031334,GO:0031386,GO:0031625,GO:0031965,GO:0032436,GO:0032880,GO:0034605,GO:0043392,GO:0043433,GO:0044388,GO:0044389,GO:0045759,GO:0045892,GO:0050821,GO:0060021,GO:0060334,GO:0071276,GO:0097165,GO:1902260,GO:1990381" "negative regulation of transcription by RNA polymerase II|RNA binding|protein binding|nucleus|nuclear envelope|nuclear pore|nucleoplasm|nucleolus|cytosol|plasma membrane|DNA repair|double-strand break repair via nonhomologous end joining|voltage-gated potassium channel complex|transcription factor binding|potassium channel regulator activity|viral process|nuclear body|PML body|nuclear speck|protein sumoylation|enzyme binding|positive regulation of protein-containing complex assembly|protein tag|ubiquitin protein ligase binding|nuclear membrane|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of protein localization|cellular response to heat|negative regulation of DNA binding|negative regulation of DNA-binding transcription factor activity|small protein activating enzyme binding|ubiquitin-like protein ligase binding|negative regulation of action potential|negative regulation of transcription, DNA-templated|protein stabilization|roof of mouth development|regulation of interferon-gamma-mediated signaling pathway|cellular response to cadmium ion|nuclear stress granule|negative regulation of delayed rectifier potassium channel activity|ubiquitin-specific protease binding" "hsa03013,hsa05418" RNA transport|Fluid shear stress and atherosclerosis other SUMO2 6401.584481 5950.126995 6853.041966 1.151747177 0.203824061 0.401785347 1 100.2992236 113.5862877 6613 small ubiquitin like modifier 2 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0016605,GO:0016925,GO:0031386,GO:0031625,GO:0032436,GO:0044389" RNA binding|protein binding|nucleus|nucleoplasm|PML body|protein sumoylation|protein tag|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|ubiquitin-like protein ligase binding "hsa03013,hsa05418" RNA transport|Fluid shear stress and atherosclerosis other SUMO3 2194.401109 1983.02886 2405.773358 1.213181213 0.278795062 0.238387844 1 57.08231155 68.09236312 6612 small ubiquitin like modifier 3 "GO:0000776,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0016605,GO:0016925,GO:0031386,GO:0043392,GO:0044389,GO:1900180" kinetochore|protein binding|nucleus|nucleoplasm|cytoplasm|PML body|protein sumoylation|protein tag|negative regulation of DNA binding|ubiquitin-like protein ligase binding|regulation of protein localization to nucleus "hsa03013,hsa05418" RNA transport|Fluid shear stress and atherosclerosis SUN1 3336.889908 3387.587602 3286.192214 0.970068556 -0.043841387 0.854422223 1 27.38402366 26.11986136 23353 Sad1 and UNC84 domain containing 1 "GO:0005515,GO:0005635,GO:0005639,GO:0006998,GO:0007283,GO:0030154,GO:0031965,GO:0034993,GO:0043231,GO:0043495,GO:0051321,GO:0090292,GO:0140444" protein binding|nuclear envelope|integral component of nuclear inner membrane|nuclear envelope organization|spermatogenesis|cell differentiation|nuclear membrane|meiotic nuclear membrane microtubule tethering complex|intracellular membrane-bounded organelle|protein-membrane adaptor activity|meiotic cell cycle|nuclear matrix anchoring at nuclear membrane|cytoskeleton-nuclear membrane anchor activity SUN2 2346.697826 2297.233853 2396.161798 1.043063942 0.060827601 0.798361779 1 21.47095422 22.02081848 25777 Sad1 and UNC84 domain containing 2 "GO:0000781,GO:0000794,GO:0005515,GO:0005521,GO:0005635,GO:0005639,GO:0006998,GO:0007052,GO:0007097,GO:0008017,GO:0010008,GO:0021817,GO:0030335,GO:0031022,GO:0031965,GO:0034993,GO:0042802,GO:0043495,GO:0051321,GO:0051642,GO:0090292,GO:0140444" "chromosome, telomeric region|condensed nuclear chromosome|protein binding|lamin binding|nuclear envelope|integral component of nuclear inner membrane|nuclear envelope organization|mitotic spindle organization|nuclear migration|microtubule binding|endosome membrane|nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration|positive regulation of cell migration|nuclear migration along microfilament|nuclear membrane|meiotic nuclear membrane microtubule tethering complex|identical protein binding|protein-membrane adaptor activity|meiotic cell cycle|centrosome localization|nuclear matrix anchoring at nuclear membrane|cytoskeleton-nuclear membrane anchor activity" SUN3 298.7144839 310.043337 287.3856308 0.926920841 -0.109481956 0.736301262 1 10.31573757 9.401867167 256979 Sad1 and UNC84 domain containing 3 "GO:0005635,GO:0005637,GO:0006998,GO:0016021,GO:0034993,GO:0043495" nuclear envelope|nuclear inner membrane|nuclear envelope organization|integral component of membrane|meiotic nuclear membrane microtubule tethering complex|protein-membrane adaptor activity SUOX 348.6298126 371.4277561 325.8318691 0.877241573 -0.188953911 0.533897646 1 2.705024111 2.333251341 6821 sulfite oxidase "GO:0005515,GO:0005739,GO:0005758,GO:0005759,GO:0006790,GO:0008482,GO:0020037,GO:0030151,GO:0043546,GO:0070221" "protein binding|mitochondrion|mitochondrial intermembrane space|mitochondrial matrix|sulfur compound metabolic process|sulfite oxidase activity|heme binding|molybdenum ion binding|molybdopterin cofactor binding|sulfide oxidation, using sulfide:quinone oxidoreductase" hsa00920 Sulfur metabolism SUPT16H 5219.694048 5227.039346 5212.348749 0.997189499 -0.004060404 0.987422731 1 59.52997931 58.36931637 11198 "SPT16 homolog, facilitates chromatin remodeling subunit" "GO:0003723,GO:0005515,GO:0005654,GO:0006260,GO:0006281,GO:0006337,GO:0006366,GO:0006368,GO:0016032,GO:0031491,GO:0032786,GO:0032968,GO:0034724,GO:0035101,GO:1901796" "RNA binding|protein binding|nucleoplasm|DNA replication|DNA repair|nucleosome disassembly|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|viral process|nucleosome binding|positive regulation of DNA-templated transcription, elongation|positive regulation of transcription elongation from RNA polymerase II promoter|DNA replication-independent nucleosome organization|FACT complex|regulation of signal transduction by p53 class mediator" SUPT20H 1756.615922 1731.248701 1781.983142 1.029305115 0.041670701 0.862812248 1 26.11463009 26.43012322 55578 "SPT20 homolog, SAGA complex component" "GO:0000124,GO:0003712,GO:0005515,GO:0006357,GO:0006914,GO:0007369,GO:0070461" SAGA complex|transcription coregulator activity|protein binding|regulation of transcription by RNA polymerase II|autophagy|gastrulation|SAGA-type complex hsa04140 Autophagy - animal other SUPT3H 234.6743099 218.4869154 250.8617045 1.148177245 0.199345369 0.566928643 1 1.110393783 1.253594666 8464 "SPT3 homolog, SAGA and STAGA complex component" "GO:0003713,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0006366,GO:0016578,GO:0030914,GO:0033276,GO:0043966,GO:0045893,GO:0046982" "transcription coactivator activity|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|histone deubiquitination|STAGA complex|transcription factor TFTC complex|histone H3 acetylation|positive regulation of transcription, DNA-templated|protein heterodimerization activity" hsa05202 Transcriptional misregulation in cancer SUPT4H1 811.0723176 753.259651 868.8849842 1.153499969 0.206017965 0.413442003 1 27.01618491 30.64169504 6827 "SPT4 homolog, DSIF elongation factor subunit" "GO:0000122,GO:0000993,GO:0005515,GO:0005654,GO:0006325,GO:0006355,GO:0006366,GO:0006368,GO:0006397,GO:0008270,GO:0032044,GO:0032785,GO:0032786,GO:0034243,GO:0034244,GO:0045944,GO:0046982,GO:0050434" "negative regulation of transcription by RNA polymerase II|RNA polymerase II complex binding|protein binding|nucleoplasm|chromatin organization|regulation of transcription, DNA-templated|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|mRNA processing|zinc ion binding|DSIF complex|negative regulation of DNA-templated transcription, elongation|positive regulation of DNA-templated transcription, elongation|regulation of transcription elongation from RNA polymerase II promoter|negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|positive regulation of viral transcription" SUPT5H 1679.128396 1816.562639 1541.694153 0.848687582 -0.236694527 0.319277169 1 25.12872197 20.96956528 6829 "SPT5 homolog, DSIF elongation factor subunit" "GO:0000122,GO:0003682,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006366,GO:0006368,GO:0006370,GO:0016239,GO:0019899,GO:0032044,GO:0032785,GO:0032786,GO:0045944,GO:0046982,GO:0050434,GO:1900364" "negative regulation of transcription by RNA polymerase II|chromatin binding|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|positive regulation of macroautophagy|enzyme binding|DSIF complex|negative regulation of DNA-templated transcription, elongation|positive regulation of DNA-templated transcription, elongation|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|positive regulation of viral transcription|negative regulation of mRNA polyadenylation" chromosome_remodelling_factor SUPT6H 2571.292632 2881.946455 2260.638808 0.784413883 -0.350313026 0.138444553 1 23.23677074 17.92223729 6830 "SPT6 homolog, histone chaperone and transcription elongation factor" "GO:0001825,GO:0003677,GO:0003723,GO:0005515,GO:0005654,GO:0006366,GO:0006368,GO:0006397,GO:0008023,GO:0008380,GO:0010793,GO:0016032,GO:0031491,GO:0032968,GO:0034728,GO:0035327,GO:0042393,GO:0042789,GO:0045191,GO:0050684,GO:0051028,GO:0051147,GO:0061086,GO:0070827" blastocyst formation|DNA binding|RNA binding|protein binding|nucleoplasm|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|mRNA processing|transcription elongation factor complex|RNA splicing|regulation of mRNA export from nucleus|viral process|nucleosome binding|positive regulation of transcription elongation from RNA polymerase II promoter|nucleosome organization|transcriptionally active chromatin|histone binding|mRNA transcription by RNA polymerase II|regulation of isotype switching|regulation of mRNA processing|mRNA transport|regulation of muscle cell differentiation|negative regulation of histone H3-K27 methylation|chromatin maintenance SUPT7L 1013.596978 1048.737194 978.4567632 0.93298566 -0.100073187 0.686198051 1 11.84783584 10.86888956 9913 "SPT7 like, STAGA complex subunit gamma" "GO:0003713,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0030914,GO:0043966,GO:0045893,GO:0046982,GO:0051457" "transcription coactivator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|STAGA complex|histone H3 acetylation|positive regulation of transcription, DNA-templated|protein heterodimerization activity|maintenance of protein location in nucleus" SUPV3L1 916.649789 925.9683556 907.3312225 0.979872819 -0.029333586 0.910288327 1 18.08167921 17.42126349 6832 Suv3 like RNA helicase "GO:0000958,GO:0000962,GO:0000965,GO:0003677,GO:0003678,GO:0003723,GO:0003724,GO:0003725,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005739,GO:0005759,GO:0006310,GO:0006401,GO:0030307,GO:0032508,GO:0034458,GO:0035945,GO:0035946,GO:0042645,GO:0042803,GO:0043066,GO:0045025,GO:0070584,GO:0070827,GO:2000827" mitochondrial mRNA catabolic process|positive regulation of mitochondrial RNA catabolic process|mitochondrial RNA 3'-end processing|DNA binding|DNA helicase activity|RNA binding|RNA helicase activity|double-stranded RNA binding|helicase activity|protein binding|ATP binding|nucleus|mitochondrion|mitochondrial matrix|DNA recombination|RNA catabolic process|positive regulation of cell growth|DNA duplex unwinding|3'-5' RNA helicase activity|mitochondrial ncRNA surveillance|mitochondrial mRNA surveillance|mitochondrial nucleoid|protein homodimerization activity|negative regulation of apoptotic process|mitochondrial degradosome|mitochondrion morphogenesis|chromatin maintenance|mitochondrial RNA surveillance SURF1 558.918563 580.5509465 537.2861794 0.925476365 -0.111731949 0.679710355 1 25.27156363 22.9968644 6834 SURF1 cytochrome c oxidase assembly factor "GO:0004129,GO:0005515,GO:0005746,GO:0006119,GO:0008535,GO:0009060,GO:0016021,GO:0022900,GO:0033617,GO:0055114,GO:1902600" cytochrome-c oxidase activity|protein binding|mitochondrial respirasome|oxidative phosphorylation|respiratory chain complex IV assembly|aerobic respiration|integral component of membrane|electron transport chain|mitochondrial cytochrome c oxidase assembly|oxidation-reduction process|proton transmembrane transport SURF2 172.6847812 206.0019488 139.3676136 0.676535414 -0.56376264 0.142466151 1 13.19801367 8.779510195 6835 surfeit 2 "GO:0003674,GO:0005654,GO:0005730,GO:0005886,GO:0008150,GO:0016607" molecular_function|nucleoplasm|nucleolus|plasma membrane|biological_process|nuclear speck SURF4 6990.843623 6570.213669 7411.473577 1.128041484 0.173820124 0.477023714 1 60.48649784 67.08952073 6836 surfeit 4 "GO:0000139,GO:0005515,GO:0005789,GO:0005793,GO:0005829,GO:0005886,GO:0006890,GO:0007030,GO:0010638,GO:0016021,GO:0030133,GO:0032527,GO:0033116,GO:0034498,GO:0035577,GO:0043312" "Golgi membrane|protein binding|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|cytosol|plasma membrane|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|positive regulation of organelle organization|integral component of membrane|transport vesicle|protein exit from endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment membrane|early endosome to Golgi transport|azurophil granule membrane|neutrophil degranulation" SURF6 520.6163637 521.2473552 519.9853722 0.997578917 -0.003497119 0.997841894 1 6.570149583 6.444566331 6838 surfeit 6 "GO:0001652,GO:0003677,GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0042273,GO:0042274" granular component|DNA binding|RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|ribosomal large subunit biogenesis|ribosomal small subunit biogenesis SUSD1 264.2072187 274.669265 253.7451724 0.923820772 -0.11431511 0.7368725 1 4.54530042 4.128777644 64420 sushi domain containing 1 "GO:0005509,GO:0016021" calcium ion binding|integral component of membrane SUSD4 5.365615685 2.080827765 8.650403604 4.157193473 2.055609892 0.230262796 1 0.029339486 0.119928917 55061 sushi domain containing 4 "GO:0005576,GO:0006958,GO:0016021,GO:0030449,GO:0045087,GO:0045957,GO:0045959" "extracellular region|complement activation, classical pathway|integral component of membrane|regulation of complement activation|innate immune response|negative regulation of complement activation, alternative pathway|negative regulation of complement activation, classical pathway" SUSD5 70.49589337 71.7885579 69.20322883 0.963986892 -0.052914565 0.949271007 1 0.749310267 0.71023814 26032 sushi domain containing 5 "GO:0005540,GO:0007155,GO:0007219,GO:0016021" hyaluronic acid binding|cell adhesion|Notch signaling pathway|integral component of membrane SUSD6 592.7263693 761.5829621 423.8697766 0.556564153 -0.845380103 0.001388457 0.237339298 7.540683294 4.126645011 9766 sushi domain containing 6 "GO:0003674,GO:0005515,GO:0005575,GO:0006974,GO:0008219,GO:0016021" molecular_function|protein binding|cellular_component|cellular response to DNA damage stimulus|cell death|integral component of membrane SUV39H1 621.5320943 634.6524684 608.4117201 0.958653358 -0.060918853 0.821104516 1 11.09045049 10.4539872 6839 suppressor of variegation 3-9 homolog 1 "GO:0000122,GO:0000183,GO:0000775,GO:0000792,GO:0000794,GO:0000976,GO:0003682,GO:0005515,GO:0005634,GO:0005652,GO:0005654,GO:0005677,GO:0006325,GO:0006364,GO:0006974,GO:0007049,GO:0008270,GO:0008757,GO:0016032,GO:0018024,GO:0030154,GO:0033553,GO:0034968,GO:0036123,GO:0036124,GO:0042054,GO:0042754,GO:0045892,GO:0046974,GO:0047485,GO:0048511,GO:0071456" "negative regulation of transcription by RNA polymerase II|rDNA heterochromatin assembly|chromosome, centromeric region|heterochromatin|condensed nuclear chromosome|transcription regulatory region sequence-specific DNA binding|chromatin binding|protein binding|nucleus|nuclear lamina|nucleoplasm|chromatin silencing complex|chromatin organization|rRNA processing|cellular response to DNA damage stimulus|cell cycle|zinc ion binding|S-adenosylmethionine-dependent methyltransferase activity|viral process|histone-lysine N-methyltransferase activity|cell differentiation|rDNA heterochromatin|histone lysine methylation|histone H3-K9 dimethylation|histone H3-K9 trimethylation|histone methyltransferase activity|negative regulation of circadian rhythm|negative regulation of transcription, DNA-templated|histone methyltransferase activity (H3-K9 specific)|protein N-terminus binding|rhythmic process|cellular response to hypoxia" hsa00310 Lysine degradation SUV39H2 327.0981528 336.0536841 318.1426214 0.946701782 -0.079018058 0.805186898 1 6.29503948 5.85980051 79723 suppressor of variegation 3-9 homolog 2 "GO:0000122,GO:0000775,GO:0000785,GO:0000976,GO:0005515,GO:0005634,GO:0005654,GO:0006333,GO:0006338,GO:0007049,GO:0008270,GO:0030154,GO:0034968,GO:0036123,GO:0036124,GO:0042754,GO:0045892,GO:0046974,GO:0048511,GO:0071456,GO:1904047" "negative regulation of transcription by RNA polymerase II|chromosome, centromeric region|chromatin|transcription regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|chromatin assembly or disassembly|chromatin remodeling|cell cycle|zinc ion binding|cell differentiation|histone lysine methylation|histone H3-K9 dimethylation|histone H3-K9 trimethylation|negative regulation of circadian rhythm|negative regulation of transcription, DNA-templated|histone methyltransferase activity (H3-K9 specific)|rhythmic process|cellular response to hypoxia|S-adenosyl-L-methionine binding" hsa00310 Lysine degradation SUZ12 1654.193676 1679.228007 1629.159345 0.970183524 -0.043670415 0.856556917 1 19.92824381 19.01052461 23512 SUZ12 polycomb repressive complex 2 subunit "GO:0001226,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0016604,GO:0021510,GO:0031490,GO:0032526,GO:0032682,GO:0035064,GO:0035098,GO:0042054,GO:0042532,GO:0045596,GO:0045814,GO:0046872,GO:0046976,GO:0050680,GO:0070317,GO:0098532" "RNA polymerase II transcription corepressor binding|protein binding|nucleus|nucleoplasm|nucleolus|nuclear body|spinal cord development|chromatin DNA binding|response to retinoic acid|negative regulation of chemokine production|methylated histone binding|ESC/E(Z) complex|histone methyltransferase activity|negative regulation of tyrosine phosphorylation of STAT protein|negative regulation of cell differentiation|negative regulation of gene expression, epigenetic|metal ion binding|histone methyltransferase activity (H3-K27 specific)|negative regulation of epithelial cell proliferation|negative regulation of G0 to G1 transition|histone H3-K27 trimethylation" other SV2A 506.4172908 476.5095583 536.3250234 1.125528364 0.170602414 0.534567082 1 5.634930055 6.236144245 9900 synaptic vesicle glycoprotein 2A "GO:0005783,GO:0005886,GO:0005911,GO:0006874,GO:0008021,GO:0014052,GO:0016021,GO:0016082,GO:0019901,GO:0022857,GO:0030285,GO:0030425,GO:0030672,GO:0031594,GO:0043005,GO:0043025,GO:0048786,GO:0055085,GO:0098978,GO:0098982" endoplasmic reticulum|plasma membrane|cell-cell junction|cellular calcium ion homeostasis|synaptic vesicle|regulation of gamma-aminobutyric acid secretion|integral component of membrane|synaptic vesicle priming|protein kinase binding|transmembrane transporter activity|integral component of synaptic vesicle membrane|dendrite|synaptic vesicle membrane|neuromuscular junction|neuron projection|neuronal cell body|presynaptic active zone|transmembrane transport|glutamatergic synapse|GABA-ergic synapse hsa04512 ECM-receptor interaction SVBP 164.3419628 138.3750464 190.3088793 1.375312126 0.459759075 0.242169078 1 9.219503 12.46751676 374969 small vasohibin binding protein "GO:0005515,GO:0005576,GO:0005737,GO:0005856,GO:0006508,GO:0008017,GO:0009306,GO:0010596,GO:0031397,GO:0045177,GO:0061564,GO:1905048" protein binding|extracellular region|cytoplasm|cytoskeleton|proteolysis|microtubule binding|protein secretion|negative regulation of endothelial cell migration|negative regulation of protein ubiquitination|apical part of cell|axon development|regulation of metallopeptidase activity SVEP1 45.36241391 30.1720026 60.55282523 2.006920987 1.004983818 0.107502545 1 0.13193153 0.260345486 79987 "sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1" "GO:0005509,GO:0005576,GO:0005634,GO:0005737,GO:0007155,GO:0016020" calcium ion binding|extracellular region|nucleus|cytoplasm|cell adhesion|membrane SVIL 1330.007945 1470.104816 1189.911074 0.809405602 -0.305065261 0.204225853 1 6.699410136 5.331801228 6840 supervillin "GO:0002102,GO:0005515,GO:0005546,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0007519,GO:0008154,GO:0015629,GO:0030496,GO:0032154,GO:0032467,GO:0036449,GO:0043034,GO:0051014,GO:0051015,GO:0051016,GO:0071437" "podosome|protein binding|phosphatidylinositol-4,5-bisphosphate binding|nucleus|cytoplasm|cytosol|plasma membrane|focal adhesion|skeletal muscle tissue development|actin polymerization or depolymerization|actin cytoskeleton|midbody|cleavage furrow|positive regulation of cytokinesis|microtubule minus-end|costamere|actin filament severing|actin filament binding|barbed-end actin filament capping|invadopodium" SVIP 514.0373414 449.4587973 578.6158855 1.287361353 0.364417065 0.179878988 1 3.751452916 4.74866077 258010 small VCP interacting protein "GO:0000139,GO:0005515,GO:0005789,GO:0005886,GO:0010508,GO:0030667,GO:0030868,GO:0031225,GO:0031333,GO:0043312,GO:0043621,GO:0051117,GO:0070062,GO:0070821,GO:1903061,GO:1903070,GO:1904153,GO:1904240" "Golgi membrane|protein binding|endoplasmic reticulum membrane|plasma membrane|positive regulation of autophagy|secretory granule membrane|smooth endoplasmic reticulum membrane|anchored component of membrane|negative regulation of protein-containing complex assembly|neutrophil degranulation|protein self-association|ATPase binding|extracellular exosome|tertiary granule membrane|positive regulation of protein lipidation|negative regulation of ER-associated ubiquitin-dependent protein catabolic process|negative regulation of retrograde protein transport, ER to cytosol|negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" hsa04141 Protein processing in endoplasmic reticulum SWAP70 2320.766122 2348.214133 2293.318111 0.976622225 -0.034127485 0.886940336 1 23.81149011 22.86569235 23075 switching B cell complex subunit SWAP70 "GO:0003677,GO:0005509,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005886,GO:0007204,GO:0015629,GO:0030027,GO:0030835,GO:0032233,GO:0032880,GO:0033633,GO:0045190,GO:0045296,GO:0051017,GO:0060754,GO:1902309" DNA binding|calcium ion binding|protein binding|ATP binding|nucleus|cytoplasm|plasma membrane|positive regulation of cytosolic calcium ion concentration|actin cytoskeleton|lamellipodium|negative regulation of actin filament depolymerization|positive regulation of actin filament bundle assembly|regulation of protein localization|negative regulation of cell-cell adhesion mediated by integrin|isotype switching|cadherin binding|actin filament bundle assembly|positive regulation of mast cell chemotaxis|negative regulation of peptidyl-serine dephosphorylation SWI5 693.0589551 632.5716406 753.5462695 1.191242574 0.252467221 0.326050399 1 34.03143734 39.86132009 375757 SWI5 homologous recombination repair protein "GO:0000724,GO:0000730,GO:0005515,GO:0005634,GO:0032798,GO:0071479" double-strand break repair via homologous recombination|DNA recombinase assembly|protein binding|nucleus|Swi5-Sfr1 complex|cellular response to ionizing radiation SWSAP1 21.9380103 20.80827765 23.06774294 1.108584926 0.148719296 0.913376404 1 1.205754109 1.314313286 126074 SWIM-type zinc finger 7 associated protein 1 "GO:0000724,GO:0003697,GO:0005515,GO:0005634,GO:0016887,GO:0050821,GO:0097196" double-strand break repair via homologous recombination|single-stranded DNA binding|protein binding|nucleus|ATPase activity|protein stabilization|Shu complex SWT1 199.8449826 187.2744989 212.4154663 1.134246614 0.181734353 0.625425181 1 1.317492197 1.469354955 54823 SWT1 RNA endoribonuclease homolog GO:0005634 nucleus SYAP1 1704.521 1612.641518 1796.400482 1.113949047 0.155683244 0.512917364 1 13.98727676 15.32038478 94056 synapse associated protein 1 "GO:0005515,GO:0005654,GO:0005794,GO:0005829,GO:0030154,GO:0030424,GO:0030425,GO:0030426,GO:0031234,GO:0032869,GO:0036120,GO:0038203,GO:0042734,GO:0043204,GO:0045211,GO:0045600,GO:0048471,GO:0070062,GO:0071364,GO:0071902,GO:1990314" protein binding|nucleoplasm|Golgi apparatus|cytosol|cell differentiation|axon|dendrite|growth cone|extrinsic component of cytoplasmic side of plasma membrane|cellular response to insulin stimulus|cellular response to platelet-derived growth factor stimulus|TORC2 signaling|presynaptic membrane|perikaryon|postsynaptic membrane|positive regulation of fat cell differentiation|perinuclear region of cytoplasm|extracellular exosome|cellular response to epidermal growth factor stimulus|positive regulation of protein serine/threonine kinase activity|cellular response to insulin-like growth factor stimulus SYBU 94.6285879 112.3646993 76.89247648 0.684311683 -0.547274517 0.252765121 1 0.812670753 0.546814174 55638 syntabulin "GO:0000139,GO:0005515,GO:0005874,GO:0005881,GO:0008017,GO:0016021,GO:0017075,GO:0019894,GO:0019896,GO:0031410,GO:0031982,GO:0043231,GO:0060074,GO:1904115" Golgi membrane|protein binding|microtubule|cytoplasmic microtubule|microtubule binding|integral component of membrane|syntaxin-1 binding|kinesin binding|axonal transport of mitochondrion|cytoplasmic vesicle|vesicle|intracellular membrane-bounded organelle|synapse maturation|axon cytoplasm SYCE1L 81.87124899 67.62690237 96.1155956 1.421262726 0.507173267 0.316471839 1 3.414497149 4.771690857 100130958 synaptonemal complex central element protein 1 like "GO:0000795,GO:0007130,GO:0045111" synaptonemal complex|synaptonemal complex assembly|intermediate filament cytoskeleton SYCE2 10.36954028 7.282897178 13.45618338 1.847641543 0.88568489 0.46436189 1 0.209981003 0.381477479 256126 synaptonemal complex central element protein 2 "GO:0000801,GO:0005515,GO:0005654,GO:0005694,GO:0007130,GO:0051301" central element|protein binding|nucleoplasm|chromosome|synaptonemal complex assembly|cell division SYCP2 28.54218468 30.1720026 26.91236677 0.891964883 -0.164941183 0.868564601 1 0.256609454 0.225056514 10388 synaptonemal complex protein 2 "GO:0000080,GO:0000795,GO:0000800,GO:0003677,GO:0005634,GO:0007130,GO:0007140,GO:0007143,GO:0009566,GO:0043066,GO:0048808,GO:0051301,GO:0140013" mitotic G1 phase|synaptonemal complex|lateral element|DNA binding|nucleus|synaptonemal complex assembly|male meiotic nuclear division|female meiotic nuclear division|fertilization|negative regulation of apoptotic process|male genitalia morphogenesis|cell division|meiotic nuclear division SYCP2L 11.56847002 13.52538047 9.61155956 0.710631363 -0.492826733 0.700204091 1 0.248134994 0.173381823 221711 synaptonemal complex protein 2 like "GO:0000080,GO:0000779,GO:0000800,GO:0005654,GO:0140013" "mitotic G1 phase|condensed chromosome, centromeric region|lateral element|nucleoplasm|meiotic nuclear division" SYDE1 948.8485135 925.9683556 971.7286715 1.049418877 0.069590646 0.781682222 1 15.19594996 15.68006668 85360 synapse defective Rho GTPase homolog 1 "GO:0005096,GO:0005829,GO:0007165,GO:0016477,GO:0030695,GO:0031532,GO:0051056,GO:0051493,GO:0090630,GO:1901165" GTPase activator activity|cytosol|signal transduction|cell migration|GTPase regulator activity|actin cytoskeleton reorganization|regulation of small GTPase mediated signal transduction|regulation of cytoskeleton organization|activation of GTPase activity|positive regulation of trophoblast cell migration SYDE2 112.5735194 104.0413883 121.1056505 1.164014172 0.219108624 0.637648292 1 0.615030757 0.703924825 84144 synapse defective Rho GTPase homolog 2 "GO:0005096,GO:0005829,GO:0007165,GO:0016477,GO:0051056,GO:0090630" GTPase activator activity|cytosol|signal transduction|cell migration|regulation of small GTPase mediated signal transduction|activation of GTPase activity SYF2 683.2838492 640.8949517 725.6727468 1.132280329 0.179231184 0.48794913 1 19.46692411 21.67317196 25949 SYF2 pre-mRNA splicing factor "GO:0000398,GO:0000974,GO:0001701,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0007095,GO:0007369,GO:0008284,GO:0016607,GO:0048568,GO:0071007,GO:0071013,GO:0071014" "mRNA splicing, via spliceosome|Prp19 complex|in utero embryonic development|RNA binding|protein binding|nucleus|nucleoplasm|mitotic G2 DNA damage checkpoint|gastrulation|positive regulation of cell population proliferation|nuclear speck|embryonic organ development|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|post-mRNA release spliceosomal complex" hsa03040 Spliceosome SYMPK 1201.774111 1270.345351 1133.202872 0.892043153 -0.164814592 0.497146338 1 16.05398924 14.08121113 8189 symplekin "GO:0000398,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005847,GO:0005856,GO:0005886,GO:0005923,GO:0006369,GO:0006378,GO:0006406,GO:0007155,GO:0016604,GO:0031124,GO:0032091,GO:0035307,GO:0097165" "mRNA splicing, via spliceosome|protein binding|nucleoplasm|cytoplasm|cytosol|mRNA cleavage and polyadenylation specificity factor complex|cytoskeleton|plasma membrane|bicellular tight junction|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA export from nucleus|cell adhesion|nuclear body|mRNA 3'-end processing|negative regulation of protein binding|positive regulation of protein dephosphorylation|nuclear stress granule" "hsa03015,hsa04530" mRNA surveillance pathway|Tight junction SYN2 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.027537598 0 6854 synapsin II "GO:0005524,GO:0005886,GO:0007268,GO:0007269,GO:0014069,GO:0017156,GO:0030672,GO:0031201,GO:0042802,GO:0045202,GO:0097091,GO:0098685,GO:0098978" ATP binding|plasma membrane|chemical synaptic transmission|neurotransmitter secretion|postsynaptic density|calcium-ion regulated exocytosis|synaptic vesicle membrane|SNARE complex|identical protein binding|synapse|synaptic vesicle clustering|Schaffer collateral - CA1 synapse|glutamatergic synapse SYNC 137.2710802 134.2133909 140.3287696 1.045564594 0.064282194 0.895645833 1 1.201597382 1.235324403 81493 "syncoilin, intermediate filament protein" "GO:0005515,GO:0005829,GO:0005882,GO:0030018,GO:0031594,GO:0042383,GO:0045103,GO:0048471" protein binding|cytosol|intermediate filament|Z disc|neuromuscular junction|sarcolemma|intermediate filament-based process|perinuclear region of cytoplasm SYNCRIP 2829.288778 2867.380661 2791.196896 0.973430886 -0.038849545 0.87093018 1 16.89224372 16.1682732 10492 synaptotagmin binding cytoplasmic RNA interacting protein "GO:0000398,GO:0001649,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005783,GO:0006396,GO:0008380,GO:0016020,GO:0016032,GO:0017148,GO:0048027,GO:0070934,GO:0070937,GO:0071013,GO:0071204,GO:0071346,GO:0097452,GO:1990904" "mRNA splicing, via spliceosome|osteoblast differentiation|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|endoplasmic reticulum|RNA processing|RNA splicing|membrane|viral process|negative regulation of translation|mRNA 5'-UTR binding|CRD-mediated mRNA stabilization|CRD-mediated mRNA stability complex|catalytic step 2 spliceosome|histone pre-mRNA 3'end processing complex|cellular response to interferon-gamma|GAIT complex|ribonucleoprotein complex" SYNDIG1L 18.57396445 20.80827765 16.33965125 0.785247656 -0.348780364 0.735839075 1 0.20220312 0.156122566 646658 synapse differentiation inducing 1 like "GO:0005794,GO:0016021" Golgi apparatus|integral component of membrane SYNE1 855.3987337 869.7860059 841.0114615 0.966917674 -0.048535035 0.850221148 1 1.623094533 1.543137026 23345 spectrin repeat containing nuclear envelope protein 1 "GO:0000932,GO:0003723,GO:0003779,GO:0005515,GO:0005521,GO:0005634,GO:0005635,GO:0005640,GO:0005654,GO:0005730,GO:0005737,GO:0005794,GO:0005856,GO:0006997,GO:0007030,GO:0007283,GO:0016021,GO:0019899,GO:0030017,GO:0031965,GO:0034993,GO:0042692,GO:0042803,GO:0045211,GO:0051015,GO:0090292,GO:0140444" P-body|RNA binding|actin binding|protein binding|lamin binding|nucleus|nuclear envelope|nuclear outer membrane|nucleoplasm|nucleolus|cytoplasm|Golgi apparatus|cytoskeleton|nucleus organization|Golgi organization|spermatogenesis|integral component of membrane|enzyme binding|sarcomere|nuclear membrane|meiotic nuclear membrane microtubule tethering complex|muscle cell differentiation|protein homodimerization activity|postsynaptic membrane|actin filament binding|nuclear matrix anchoring at nuclear membrane|cytoskeleton-nuclear membrane anchor activity SYNE2 2559.30272 2920.441769 2198.163671 0.752681904 -0.409887808 0.083062025 1 6.547305593 4.845574392 23224 spectrin repeat containing nuclear envelope protein 2 "GO:0003779,GO:0005515,GO:0005634,GO:0005635,GO:0005640,GO:0005654,GO:0005737,GO:0005739,GO:0005925,GO:0007097,GO:0016021,GO:0016529,GO:0021817,GO:0030018,GO:0030335,GO:0031022,GO:0031258,GO:0031527,GO:0031965,GO:0031981,GO:0033017,GO:0034993,GO:0045111,GO:0051015,GO:0051642,GO:0070062,GO:0140444,GO:1902017" actin binding|protein binding|nucleus|nuclear envelope|nuclear outer membrane|nucleoplasm|cytoplasm|mitochondrion|focal adhesion|nuclear migration|integral component of membrane|sarcoplasmic reticulum|nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration|Z disc|positive regulation of cell migration|nuclear migration along microfilament|lamellipodium membrane|filopodium membrane|nuclear membrane|nuclear lumen|sarcoplasmic reticulum membrane|meiotic nuclear membrane microtubule tethering complex|intermediate filament cytoskeleton|actin filament binding|centrosome localization|extracellular exosome|cytoskeleton-nuclear membrane anchor activity|regulation of cilium assembly SYNE3 540.9887228 551.4193578 530.5580877 0.962168049 -0.055639203 0.842220713 1 1.843181615 1.743774167 161176 spectrin repeat containing nuclear envelope family member 3 "GO:0005515,GO:0005635,GO:0005640,GO:0005737,GO:0005791,GO:0007010,GO:0007097,GO:0008360,GO:0016020,GO:0016021,GO:0031965,GO:0034993,GO:0051015,GO:0090150,GO:0140444" protein binding|nuclear envelope|nuclear outer membrane|cytoplasm|rough endoplasmic reticulum|cytoskeleton organization|nuclear migration|regulation of cell shape|membrane|integral component of membrane|nuclear membrane|meiotic nuclear membrane microtubule tethering complex|actin filament binding|establishment of protein localization to membrane|cytoskeleton-nuclear membrane anchor activity SYNE4 4.562975582 6.242483296 2.883467868 0.461910386 -1.11431511 0.584550016 1 0.241938896 0.109884036 163183 spectrin repeat containing nuclear envelope family member 4 "GO:0005515,GO:0031309,GO:0034993,GO:0045198" protein binding|integral component of nuclear outer membrane|meiotic nuclear membrane microtubule tethering complex|establishment of epithelial cell apical/basal polarity SYNGAP1 641.2156697 684.5923348 597.8390046 0.873277386 -0.195488114 0.453643969 1 6.075063964 5.216440374 8831 synaptic Ras GTPase activating protein 1 "GO:0000165,GO:0005096,GO:0005515,GO:0005829,GO:0005886,GO:0007265,GO:0007389,GO:0008542,GO:0014069,GO:0016358,GO:0017124,GO:0043113,GO:0043198,GO:0043408,GO:0043524,GO:0043547,GO:0046580,GO:0048167,GO:0048169,GO:0050771,GO:0050803,GO:0098880,GO:0098978" MAPK cascade|GTPase activator activity|protein binding|cytosol|plasma membrane|Ras protein signal transduction|pattern specification process|visual learning|postsynaptic density|dendrite development|SH3 domain binding|receptor clustering|dendritic shaft|regulation of MAPK cascade|negative regulation of neuron apoptotic process|positive regulation of GTPase activity|negative regulation of Ras protein signal transduction|regulation of synaptic plasticity|regulation of long-term neuronal synaptic plasticity|negative regulation of axonogenesis|regulation of synapse structure or activity|maintenance of postsynaptic specialization structure|glutamatergic synapse hsa04014 Ras signaling pathway SYNGR1 460.574299 446.3375557 474.8110423 1.063793616 0.089218284 0.755153011 1 4.480010346 4.68605709 9145 synaptogyrin 1 "GO:0005515,GO:0005886,GO:0006605,GO:0030285,GO:0030672,GO:0031594,GO:0035577,GO:0042470,GO:0043312,GO:0045055,GO:0048169,GO:0048172,GO:0048499,GO:1990830" protein binding|plasma membrane|protein targeting|integral component of synaptic vesicle membrane|synaptic vesicle membrane|neuromuscular junction|azurophil granule membrane|melanosome|neutrophil degranulation|regulated exocytosis|regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity|synaptic vesicle membrane organization|cellular response to leukemia inhibitory factor SYNGR2 2025.357162 1885.229955 2165.484369 1.148657946 0.199949248 0.398398239 1 65.71604037 74.22210851 9144 synaptogyrin 2 "GO:0005515,GO:0005811,GO:0016021,GO:0016032,GO:0030672,GO:0031594,GO:0045055,GO:0048499,GO:0070062" protein binding|lipid droplet|integral component of membrane|viral process|synaptic vesicle membrane|neuromuscular junction|regulated exocytosis|synaptic vesicle membrane organization|extracellular exosome SYNGR3 284.2826677 246.5780902 321.9872453 1.30582261 0.384958927 0.231621446 1 6.495271215 8.339742715 9143 synaptogyrin 3 "GO:0005515,GO:0008021,GO:0016021,GO:0021762,GO:0030672,GO:0031594,GO:0032411,GO:0045055" protein binding|synaptic vesicle|integral component of membrane|substantia nigra development|synaptic vesicle membrane|neuromuscular junction|positive regulation of transporter activity|regulated exocytosis SYNJ1 518.897227 513.964458 523.829996 1.019194981 0.027430078 0.926891193 1 3.827705624 3.835897424 8867 synaptojanin 1 "GO:0003723,GO:0004438,GO:0004439,GO:0005829,GO:0005874,GO:0006661,GO:0006836,GO:0007420,GO:0007612,GO:0012506,GO:0016082,GO:0016191,GO:0017124,GO:0030117,GO:0030132,GO:0034595,GO:0043195,GO:0043647,GO:0043812,GO:0046488,GO:0046855,GO:0046856,GO:0048471,GO:0048488,GO:0048489,GO:0061024,GO:0097060,GO:0098793,GO:1904980" "RNA binding|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|cytosol|microtubule|phosphatidylinositol biosynthetic process|neurotransmitter transport|brain development|learning|vesicle membrane|synaptic vesicle priming|synaptic vesicle uncoating|SH3 domain binding|membrane coat|clathrin coat of coated pit|phosphatidylinositol phosphate 5-phosphatase activity|terminal bouton|inositol phosphate metabolic process|phosphatidylinositol-4-phosphate phosphatase activity|phosphatidylinositol metabolic process|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|perinuclear region of cytoplasm|synaptic vesicle endocytosis|synaptic vesicle transport|membrane organization|synaptic membrane|presynapse|positive regulation of endosome organization" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system SYNJ2 1522.217786 1721.884976 1322.550595 0.76808301 -0.380665857 0.110415258 1 8.684796944 6.55902077 8871 synaptojanin 2 "GO:0003723,GO:0004439,GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0006661,GO:0007420,GO:0017124,GO:0030165,GO:0042995,GO:0045121,GO:0046855,GO:0046856,GO:0048471,GO:0048488,GO:0061024,GO:0098793" "RNA binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding|cytosol|cytoskeleton|plasma membrane|phosphatidylinositol biosynthetic process|brain development|SH3 domain binding|PDZ domain binding|cell projection|membrane raft|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|perinuclear region of cytoplasm|synaptic vesicle endocytosis|membrane organization|presynapse" "hsa00562,hsa04070" Inositol phosphate metabolism|Phosphatidylinositol signaling system SYNJ2BP 755.0327782 783.4316536 726.6339027 0.927501333 -0.10857874 0.671762195 1 5.924657428 5.40317414 55333 synaptojanin 2 binding protein "GO:0001937,GO:0005515,GO:0005739,GO:0005741,GO:0007268,GO:0008328,GO:0008593,GO:0009790,GO:0010596,GO:0016323,GO:0016525,GO:0030054,GO:0031594,GO:0043005,GO:0043113,GO:0045197,GO:0070373,GO:0097120,GO:0098609,GO:0098839,GO:1903671" negative regulation of endothelial cell proliferation|protein binding|mitochondrion|mitochondrial outer membrane|chemical synaptic transmission|ionotropic glutamate receptor complex|regulation of Notch signaling pathway|embryo development|negative regulation of endothelial cell migration|basolateral plasma membrane|negative regulation of angiogenesis|cell junction|neuromuscular junction|neuron projection|receptor clustering|establishment or maintenance of epithelial cell apical/basal polarity|negative regulation of ERK1 and ERK2 cascade|receptor localization to synapse|cell-cell adhesion|postsynaptic density membrane|negative regulation of sprouting angiogenesis SYNM 208.6683789 254.9014012 162.4353566 0.637247798 -0.650073613 0.068875184 1 2.068047932 1.295806405 23336 synemin "GO:0005200,GO:0005515,GO:0005882,GO:0005912,GO:0008307,GO:0017166,GO:0019215,GO:0031443,GO:0042383,GO:0043034,GO:0045104,GO:0045111,GO:0060053" structural constituent of cytoskeleton|protein binding|intermediate filament|adherens junction|structural constituent of muscle|vinculin binding|intermediate filament binding|fast-twitch skeletal muscle fiber contraction|sarcolemma|costamere|intermediate filament cytoskeleton organization|intermediate filament cytoskeleton|neurofilament cytoskeleton SYNPO 556.8817802 665.8648849 447.8986755 0.672656999 -0.57205706 0.032028865 0.912489023 3.34708346 2.213764333 11346 synaptopodin "GO:0001725,GO:0003779,GO:0005515,GO:0005634,GO:0005829,GO:0005923,GO:0014069,GO:0015629,GO:0030018,GO:0032233,GO:0043197,GO:0043204,GO:0097444,GO:0098886,GO:1905355" stress fiber|actin binding|protein binding|nucleus|cytosol|bicellular tight junction|postsynaptic density|actin cytoskeleton|Z disc|positive regulation of actin filament bundle assembly|dendritic spine|perikaryon|spine apparatus|modification of dendritic spine|spine apparatus assembly hsa04530 Tight junction SYNPO2 46.43742634 45.77821084 47.09664184 1.028800405 0.040963116 0.98679606 1 0.177396092 0.179451194 171024 synaptopodin 2 "GO:0000045,GO:0001725,GO:0003779,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005925,GO:0015629,GO:0030018,GO:0030674,GO:0031005,GO:0032233,GO:0043231,GO:0051371,GO:0051393,GO:0061684,GO:0071889,GO:0099023" autophagosome assembly|stress fiber|actin binding|protein binding|nucleus|nucleoplasm|cytosol|focal adhesion|actin cytoskeleton|Z disc|protein-macromolecule adaptor activity|filamin binding|positive regulation of actin filament bundle assembly|intracellular membrane-bounded organelle|muscle alpha-actinin binding|alpha-actinin binding|chaperone-mediated autophagy|14-3-3 protein binding|vesicle tethering complex SYNRG 1289.823677 1310.921492 1268.725862 0.967812237 -0.047200914 0.847531239 1 8.051728699 7.6621636 11276 synergin gamma "GO:0005515,GO:0005737,GO:0005794,GO:0006886,GO:0006897,GO:0030121,GO:0030130" protein binding|cytoplasm|Golgi apparatus|intracellular protein transport|endocytosis|AP-1 adaptor complex|clathrin coat of trans-Golgi network vesicle SYP 20.05532735 21.84869154 18.26196316 0.835837841 -0.258705019 0.811013347 1 0.48162929 0.395827623 6855 synaptophysin "GO:0005515,GO:0006897,GO:0008021,GO:0015485,GO:0016188,GO:0017075,GO:0030285,GO:0030672,GO:0031594,GO:0042169,GO:0042734,GO:0042802,GO:0043005,GO:0043195,GO:0043621,GO:0048168,GO:0048169,GO:0048172,GO:0048471,GO:0048488,GO:0048499,GO:0048786,GO:0060076,GO:0071310,GO:0098685,GO:2000300,GO:2000474" protein binding|endocytosis|synaptic vesicle|cholesterol binding|synaptic vesicle maturation|syntaxin-1 binding|integral component of synaptic vesicle membrane|synaptic vesicle membrane|neuromuscular junction|SH2 domain binding|presynaptic membrane|identical protein binding|neuron projection|terminal bouton|protein self-association|regulation of neuronal synaptic plasticity|regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity|perinuclear region of cytoplasm|synaptic vesicle endocytosis|synaptic vesicle membrane organization|presynaptic active zone|excitatory synapse|cellular response to organic substance|Schaffer collateral - CA1 synapse|regulation of synaptic vesicle exocytosis|regulation of opioid receptor signaling pathway SYPL1 2508.513596 2344.052478 2672.974714 1.140322044 0.189441321 0.423224108 1 51.52297057 57.76963095 6856 synaptophysin like 1 "GO:0005515,GO:0005887,GO:0007268,GO:0016021,GO:0017075,GO:0030141,GO:0030285,GO:0030672,GO:0042470,GO:0070062" protein binding|integral component of plasma membrane|chemical synaptic transmission|integral component of membrane|syntaxin-1 binding|secretory granule|integral component of synaptic vesicle membrane|synaptic vesicle membrane|melanosome|extracellular exosome SYS1 883.0539899 914.5238028 851.584177 0.931177706 -0.102871577 0.682261358 1 9.184504052 8.409292494 90196 SYS1 golgi trafficking protein "GO:0005515,GO:0005802,GO:0005829,GO:0006895,GO:0030173,GO:0032588,GO:0034067,GO:0043001" protein binding|trans-Golgi network|cytosol|Golgi to endosome transport|integral component of Golgi membrane|trans-Golgi network membrane|protein localization to Golgi apparatus|Golgi to plasma membrane protein transport SYT1 12.89131706 10.40413883 15.3784953 1.478113235 0.563756795 0.626027011 1 0.104566811 0.151975209 6857 synaptotagmin 1 "GO:0000149,GO:0001786,GO:0005509,GO:0005513,GO:0005515,GO:0005516,GO:0005544,GO:0005546,GO:0005737,GO:0005794,GO:0005886,GO:0007268,GO:0007269,GO:0007420,GO:0008021,GO:0008022,GO:0014047,GO:0014059,GO:0016192,GO:0017075,GO:0017156,GO:0017157,GO:0017158,GO:0019905,GO:0030154,GO:0030276,GO:0030285,GO:0030348,GO:0030424,GO:0030665,GO:0030672,GO:0031045,GO:0033603,GO:0042584,GO:0042734,GO:0042802,GO:0043005,GO:0044306,GO:0046982,GO:0048278,GO:0048306,GO:0048488,GO:0048791,GO:0050750,GO:0050806,GO:0051291,GO:0051966,GO:0060076,GO:0060201,GO:0060203,GO:0061024,GO:0061202,GO:0061669,GO:0061891,GO:0070083,GO:0070382,GO:0071277,GO:0071911,GO:0098686,GO:0098746,GO:0098978,GO:0099502,GO:1903235,GO:1903305,GO:1903861" "SNARE binding|phosphatidylserine binding|calcium ion binding|detection of calcium ion|protein binding|calmodulin binding|calcium-dependent phospholipid binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|Golgi apparatus|plasma membrane|chemical synaptic transmission|neurotransmitter secretion|brain development|synaptic vesicle|protein C-terminus binding|glutamate secretion|regulation of dopamine secretion|vesicle-mediated transport|syntaxin-1 binding|calcium-ion regulated exocytosis|regulation of exocytosis|regulation of calcium ion-dependent exocytosis|syntaxin binding|cell differentiation|clathrin binding|integral component of synaptic vesicle membrane|syntaxin-3 binding|axon|clathrin-coated vesicle membrane|synaptic vesicle membrane|dense core granule|positive regulation of dopamine secretion|chromaffin granule membrane|presynaptic membrane|identical protein binding|neuron projection|neuron projection terminus|protein heterodimerization activity|vesicle docking|calcium-dependent protein binding|synaptic vesicle endocytosis|calcium ion-regulated exocytosis of neurotransmitter|low-density lipoprotein particle receptor binding|positive regulation of synaptic transmission|protein heterooligomerization|regulation of synaptic transmission, glutamatergic|excitatory synapse|clathrin-sculpted acetylcholine transport vesicle membrane|clathrin-sculpted glutamate transport vesicle membrane|membrane organization|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|spontaneous neurotransmitter secretion|calcium ion sensor activity|clathrin-sculpted monoamine transport vesicle membrane|exocytic vesicle|cellular response to calcium ion|synchronous neurotransmitter secretion|hippocampal mossy fiber to CA3 synapse|fast, calcium ion-dependent exocytosis of neurotransmitter|glutamatergic synapse|calcium-dependent activation of synaptic vesicle fusion|positive regulation of calcium ion-dependent exocytosis of neurotransmitter|regulation of regulated secretory pathway|positive regulation of dendrite extension" hsa04721 Synaptic vesicle cycle SYT11 36.51386549 24.96993318 48.0577978 1.924626608 0.944578579 0.163680939 1 0.253538706 0.479801868 23208 synaptotagmin 11 "GO:0000149,GO:0001778,GO:0001786,GO:0001818,GO:0001891,GO:0005509,GO:0005515,GO:0005544,GO:0005764,GO:0005765,GO:0005802,GO:0005886,GO:0006906,GO:0006914,GO:0007612,GO:0007613,GO:0008021,GO:0014059,GO:0014069,GO:0016192,GO:0017156,GO:0017158,GO:0030276,GO:0030424,GO:0030425,GO:0030665,GO:0031369,GO:0031625,GO:0031982,GO:0032009,GO:0032715,GO:0032720,GO:0033602,GO:0042802,GO:0043005,GO:0043195,GO:0043197,GO:0043204,GO:0045202,GO:0045335,GO:0045806,GO:0046929,GO:0048471,GO:0048487,GO:0048787,GO:0050765,GO:0051650,GO:0055037,GO:0055038,GO:0060076,GO:0060077,GO:0070382,GO:0071277,GO:0098685,GO:0098793,GO:0099059,GO:1900186,GO:1900243,GO:1900424,GO:1903979,GO:1905154,GO:1905162,GO:1905171,GO:1905469,GO:1990927" SNARE binding|plasma membrane repair|phosphatidylserine binding|negative regulation of cytokine production|phagocytic cup|calcium ion binding|protein binding|calcium-dependent phospholipid binding|lysosome|lysosomal membrane|trans-Golgi network|plasma membrane|vesicle fusion|autophagy|learning|memory|synaptic vesicle|regulation of dopamine secretion|postsynaptic density|vesicle-mediated transport|calcium-ion regulated exocytosis|regulation of calcium ion-dependent exocytosis|clathrin binding|axon|dendrite|clathrin-coated vesicle membrane|translation initiation factor binding|ubiquitin protein ligase binding|vesicle|early phagosome|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|negative regulation of dopamine secretion|identical protein binding|neuron projection|terminal bouton|dendritic spine|perikaryon|synapse|phagocytic vesicle|negative regulation of endocytosis|negative regulation of neurotransmitter secretion|perinuclear region of cytoplasm|beta-tubulin binding|presynaptic active zone membrane|negative regulation of phagocytosis|establishment of vesicle localization|recycling endosome|recycling endosome membrane|excitatory synapse|inhibitory synapse|exocytic vesicle|cellular response to calcium ion|Schaffer collateral - CA1 synapse|presynapse|integral component of presynaptic active zone membrane|negative regulation of clathrin-dependent endocytosis|negative regulation of synaptic vesicle endocytosis|regulation of defense response to bacterium|negative regulation of microglial cell activation|negative regulation of membrane invagination|regulation of phagosome maturation|positive regulation of protein localization to phagocytic vesicle|negative regulation of clathrin-coated pit assembly|calcium ion regulated lysosome exocytosis SYT12 12.12830592 15.60620824 8.650403604 0.554292463 -0.851280704 0.441608596 1 0.154093367 0.083983525 91683 synaptotagmin 12 "GO:0000149,GO:0001786,GO:0005509,GO:0005544,GO:0005886,GO:0014059,GO:0016021,GO:0016192,GO:0017156,GO:0017158,GO:0019905,GO:0030276,GO:0030672,GO:0046928,GO:0048792,GO:0060291,GO:0070382,GO:0071277,GO:0098686" SNARE binding|phosphatidylserine binding|calcium ion binding|calcium-dependent phospholipid binding|plasma membrane|regulation of dopamine secretion|integral component of membrane|vesicle-mediated transport|calcium-ion regulated exocytosis|regulation of calcium ion-dependent exocytosis|syntaxin binding|clathrin binding|synaptic vesicle membrane|regulation of neurotransmitter secretion|spontaneous exocytosis of neurotransmitter|long-term synaptic potentiation|exocytic vesicle|cellular response to calcium ion|hippocampal mossy fiber to CA3 synapse SYT15 3.562190663 5.202069413 1.922311912 0.369528309 -1.436243205 0.543489417 1 0.039329209 0.014290062 83849 synaptotagmin 15 "GO:0000149,GO:0001786,GO:0005509,GO:0005544,GO:0005886,GO:0014059,GO:0016021,GO:0016192,GO:0017156,GO:0017158,GO:0030276,GO:0070382,GO:0071277" SNARE binding|phosphatidylserine binding|calcium ion binding|calcium-dependent phospholipid binding|plasma membrane|regulation of dopamine secretion|integral component of membrane|vesicle-mediated transport|calcium-ion regulated exocytosis|regulation of calcium ion-dependent exocytosis|clathrin binding|exocytic vesicle|cellular response to calcium ion SYT16 350.0224711 294.4371288 405.6078134 1.377570197 0.462125836 0.123969877 1 0.896841985 1.214788992 83851 synaptotagmin 16 "GO:0005515,GO:0005543,GO:0006887,GO:0042802" protein binding|phospholipid binding|exocytosis|identical protein binding SYT17 63.24256432 83.23311061 43.25201802 0.519649184 -0.944390108 0.086280381 1 0.950363316 0.485591518 51760 synaptotagmin 17 "GO:0000149,GO:0001786,GO:0005509,GO:0005515,GO:0005544,GO:0005886,GO:0014059,GO:0016192,GO:0017156,GO:0017158,GO:0019905,GO:0030154,GO:0030276,GO:0070382,GO:0071277,GO:1903861" SNARE binding|phosphatidylserine binding|calcium ion binding|protein binding|calcium-dependent phospholipid binding|plasma membrane|regulation of dopamine secretion|vesicle-mediated transport|calcium-ion regulated exocytosis|regulation of calcium ion-dependent exocytosis|syntaxin binding|cell differentiation|clathrin binding|exocytic vesicle|cellular response to calcium ion|positive regulation of dendrite extension SYT5 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.036634029 0.022184637 6861 synaptotagmin 5 "GO:0000149,GO:0001786,GO:0005509,GO:0005544,GO:0005546,GO:0005886,GO:0007268,GO:0014059,GO:0016192,GO:0017156,GO:0017158,GO:0019905,GO:0030276,GO:0030424,GO:0030672,GO:0031045,GO:0043025,GO:0046982,GO:0048471,GO:0048488,GO:0048791,GO:0055038,GO:0070382,GO:0071277,GO:0099066,GO:1990769" "SNARE binding|phosphatidylserine binding|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylinositol-4,5-bisphosphate binding|plasma membrane|chemical synaptic transmission|regulation of dopamine secretion|vesicle-mediated transport|calcium-ion regulated exocytosis|regulation of calcium ion-dependent exocytosis|syntaxin binding|clathrin binding|axon|synaptic vesicle membrane|dense core granule|neuronal cell body|protein heterodimerization activity|perinuclear region of cytoplasm|synaptic vesicle endocytosis|calcium ion-regulated exocytosis of neurotransmitter|recycling endosome membrane|exocytic vesicle|cellular response to calcium ion|integral component of neuronal dense core vesicle membrane|proximal neuron projection" SYTL1 142.2353759 138.3750464 146.0957053 1.055795168 0.078329968 0.866265661 1 3.430014818 3.560793961 84958 synaptotagmin like 1 "GO:0005515,GO:0005886,GO:0006886,GO:0006887,GO:0019897,GO:0031528,GO:0042043,GO:0042470,GO:0070062,GO:0070382" protein binding|plasma membrane|intracellular protein transport|exocytosis|extrinsic component of plasma membrane|microvillus membrane|neurexin family protein binding|melanosome|extracellular exosome|exocytic vesicle SYTL2 247.4712778 264.2651262 230.6774294 0.872901517 -0.196109201 0.565515481 1 1.414152621 1.213759688 54843 synaptotagmin like 2 "GO:0001786,GO:0005515,GO:0005546,GO:0005737,GO:0005886,GO:0006886,GO:0006887,GO:0006904,GO:0010923,GO:0016020,GO:0016192,GO:0019897,GO:0019902,GO:0042043,GO:0042470,GO:0070382" "phosphatidylserine binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|plasma membrane|intracellular protein transport|exocytosis|vesicle docking involved in exocytosis|negative regulation of phosphatase activity|membrane|vesicle-mediated transport|extrinsic component of plasma membrane|phosphatase binding|neurexin family protein binding|melanosome|exocytic vesicle" SYTL3 297.6350555 206.0019488 389.2681622 1.889633397 0.918106368 0.003761675 0.381043789 2.078250546 3.86141641 94120 synaptotagmin like 3 "GO:0005515,GO:0005544,GO:0005886,GO:0006886,GO:0006887,GO:0019897,GO:0042043,GO:0070382" protein binding|calcium-dependent phospholipid binding|plasma membrane|intracellular protein transport|exocytosis|extrinsic component of plasma membrane|neurexin family protein binding|exocytic vesicle SYTL4 556.1891949 496.277422 616.1009678 1.241444685 0.312019981 0.243032768 1 3.865919412 4.719014901 94121 synaptotagmin like 4 "GO:0001778,GO:0002576,GO:0005515,GO:0005543,GO:0005768,GO:0005886,GO:0006886,GO:0006887,GO:0019898,GO:0030658,GO:0031092,GO:0032418,GO:0042043,GO:0045921,GO:0046676,GO:0046872,GO:0050714,GO:0070382,GO:0071985,GO:1905684" plasma membrane repair|platelet degranulation|protein binding|phospholipid binding|endosome|plasma membrane|intracellular protein transport|exocytosis|extrinsic component of membrane|transport vesicle membrane|platelet alpha granule membrane|lysosome localization|neurexin family protein binding|positive regulation of exocytosis|negative regulation of insulin secretion|metal ion binding|positive regulation of protein secretion|exocytic vesicle|multivesicular body sorting pathway|regulation of plasma membrane repair SYVN1 916.8284265 880.1901447 953.4667083 1.083250834 0.115367347 0.644264262 1 12.04773796 12.83233603 84447 synoviolin 1 "GO:0000836,GO:0000839,GO:0002327,GO:0005515,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0005790,GO:0006511,GO:0016020,GO:0016567,GO:0030176,GO:0030433,GO:0030970,GO:0036498,GO:0036503,GO:0036513,GO:0044322,GO:0046872,GO:0050821,GO:0051082,GO:0051087,GO:0051117,GO:0061630,GO:0070936,GO:1902236,GO:1904380,GO:1990381" "Hrd1p ubiquitin ligase complex|Hrd1p ubiquitin ligase ERAD-L complex|immature B cell differentiation|protein binding|nucleoplasm|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|smooth endoplasmic reticulum|ubiquitin-dependent protein catabolic process|membrane|protein ubiquitination|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|IRE1-mediated unfolded protein response|ERAD pathway|Derlin-1 retrotranslocation complex|endoplasmic reticulum quality control compartment|metal ion binding|protein stabilization|unfolded protein binding|chaperone binding|ATPase binding|ubiquitin protein ligase activity|protein K48-linked ubiquitination|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|endoplasmic reticulum mannose trimming|ubiquitin-specific protease binding" "hsa04120,hsa04141" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum SZRD1 3364.619391 3446.891193 3282.34759 0.952263186 -0.070567735 0.766925451 1 52.86041605 49.49470621 26099 SUZ RNA binding domain containing 1 SZT2 1080.078443 1343.174322 816.9825626 0.608247603 -0.717269364 0.003384161 0.373212871 6.226784654 3.724049384 23334 SZT2 subunit of KICSTOR complex "GO:0003674,GO:0005515,GO:0005765,GO:0005777,GO:0007417,GO:0009791,GO:0021540,GO:0034198,GO:0042149,GO:0043473,GO:0061462,GO:0061700,GO:0140007,GO:1901668,GO:1904262,GO:1990130" molecular_function|protein binding|lysosomal membrane|peroxisome|central nervous system development|post-embryonic development|corpus callosum morphogenesis|cellular response to amino acid starvation|cellular response to glucose starvation|pigmentation|protein localization to lysosome|GATOR2 complex|KICSTOR complex|regulation of superoxide dismutase activity|negative regulation of TORC1 signaling|GATOR1 complex TAB1 614.8882909 624.2483296 605.5282523 0.97001181 -0.043925782 0.872760227 1 8.673518883 8.272628635 10454 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 "GO:0000185,GO:0000187,GO:0001701,GO:0002223,GO:0002755,GO:0003007,GO:0003279,GO:0004724,GO:0005515,GO:0005634,GO:0005829,GO:0006469,GO:0006470,GO:0007179,GO:0007249,GO:0007254,GO:0008047,GO:0010008,GO:0016579,GO:0016607,GO:0019209,GO:0030324,GO:0032991,GO:0035904,GO:0038095,GO:0044877,GO:0048273,GO:0051092,GO:0060976,GO:0070423,GO:0070498" activation of MAPKKK activity|activation of MAPK activity|in utero embryonic development|stimulatory C-type lectin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|heart morphogenesis|cardiac septum development|magnesium-dependent protein serine/threonine phosphatase activity|protein binding|nucleus|cytosol|negative regulation of protein kinase activity|protein dephosphorylation|transforming growth factor beta receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|JNK cascade|enzyme activator activity|endosome membrane|protein deubiquitination|nuclear speck|kinase activator activity|lung development|protein-containing complex|aorta development|Fc-epsilon receptor signaling pathway|protein-containing complex binding|mitogen-activated protein kinase p38 binding|positive regulation of NF-kappaB transcription factor activity|coronary vasculature development|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway "hsa04010,hsa04064,hsa04380,hsa04620,hsa04621,hsa04668,hsa05130,hsa05131,hsa05132,hsa05135,hsa05140,hsa05145,hsa05161,hsa05168,hsa05169,hsa05170" MAPK signaling pathway|NF-kappa B signaling pathway|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|TNF signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Leishmaniasis|Toxoplasmosis|Hepatitis B|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection TAB2 2363.843919 2482.427524 2245.260313 0.904461577 -0.144868879 0.540540628 1 20.96243583 18.64245257 23118 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 "GO:0000187,GO:0002223,GO:0002755,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0007249,GO:0007254,GO:0007507,GO:0010008,GO:0010507,GO:0032496,GO:0038095,GO:0043123,GO:0043130,GO:0045860,GO:0046872,GO:0050852,GO:0051092,GO:0070423,GO:0070498,GO:0070530" activation of MAPK activity|stimulatory C-type lectin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|protein binding|nucleoplasm|cytosol|plasma membrane|I-kappaB kinase/NF-kappaB signaling|JNK cascade|heart development|endosome membrane|negative regulation of autophagy|response to lipopolysaccharide|Fc-epsilon receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|positive regulation of protein kinase activity|metal ion binding|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|K63-linked polyubiquitin modification-dependent protein binding "hsa04010,hsa04064,hsa04380,hsa04620,hsa04621,hsa04657,hsa04668,hsa05130,hsa05131,hsa05132,hsa05135,hsa05140,hsa05145,hsa05161,hsa05162,hsa05168,hsa05169,hsa05170,hsa05171" MAPK signaling pathway|NF-kappa B signaling pathway|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Leishmaniasis|Toxoplasmosis|Hepatitis B|Measles|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19 TAB3 1803.032612 1927.886925 1678.178299 0.870475482 -0.200124432 0.398981873 1 10.80300103 9.246388549 257397 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 "GO:0000187,GO:0002223,GO:0002755,GO:0005515,GO:0005829,GO:0005886,GO:0007249,GO:0007254,GO:0010008,GO:0010507,GO:0038095,GO:0043123,GO:0043130,GO:0046872,GO:0051092,GO:0070062,GO:0070423,GO:0070498" activation of MAPK activity|stimulatory C-type lectin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|protein binding|cytosol|plasma membrane|I-kappaB kinase/NF-kappaB signaling|JNK cascade|endosome membrane|negative regulation of autophagy|Fc-epsilon receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|metal ion binding|positive regulation of NF-kappaB transcription factor activity|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway "hsa04064,hsa04621,hsa04657,hsa04668,hsa05130,hsa05131,hsa05132" NF-kappa B signaling pathway|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection TACC1 1804.598877 1817.603053 1791.594702 0.985690852 -0.020792858 0.932548842 1 8.838463264 8.566208991 6867 transforming acidic coiled-coil containing protein 1 "GO:0000226,GO:0005515,GO:0005634,GO:0005737,GO:0005815,GO:0005829,GO:0007052,GO:0008283,GO:0016020,GO:0016922,GO:0021987,GO:0030331,GO:0030374,GO:0030496,GO:0035259,GO:0042974,GO:0042975,GO:0045893,GO:0046965,GO:0046966,GO:0051301" "microtubule cytoskeleton organization|protein binding|nucleus|cytoplasm|microtubule organizing center|cytosol|mitotic spindle organization|cell population proliferation|membrane|nuclear receptor binding|cerebral cortex development|estrogen receptor binding|nuclear receptor coactivator activity|midbody|glucocorticoid receptor binding|retinoic acid receptor binding|peroxisome proliferator activated receptor binding|positive regulation of transcription, DNA-templated|retinoid X receptor binding|thyroid hormone receptor binding|cell division" TACC2 244.9394402 286.1138177 203.7650627 0.712181831 -0.489682464 0.146492866 1 1.262244242 0.883904748 10579 transforming acidic coiled-coil containing protein 2 "GO:0000226,GO:0005654,GO:0005737,GO:0005815,GO:0005829,GO:0005886,GO:0007052,GO:0008283,GO:0021987,GO:0035257" microtubule cytoskeleton organization|nucleoplasm|cytoplasm|microtubule organizing center|cytosol|plasma membrane|mitotic spindle organization|cell population proliferation|cerebral cortex development|nuclear hormone receptor binding TACC3 3564.093236 3561.33672 3566.849753 1.001548023 0.002231599 0.993856846 1 58.10516518 57.22129692 10460 transforming acidic coiled-coil containing protein 3 "GO:0000226,GO:0000922,GO:0005515,GO:0005737,GO:0005829,GO:0007052,GO:0007091,GO:0008283,GO:0021987,GO:0034451,GO:0043231,GO:0051301,GO:0060236,GO:0072686,GO:1902850" microtubule cytoskeleton organization|spindle pole|protein binding|cytoplasm|cytosol|mitotic spindle organization|metaphase/anaphase transition of mitotic cell cycle|cell population proliferation|cerebral cortex development|centriolar satellite|intracellular membrane-bounded organelle|cell division|regulation of mitotic spindle organization|mitotic spindle|microtubule cytoskeleton organization involved in mitosis hsa03013 RNA transport TACO1 494.1600372 482.7520415 505.5680329 1.04726234 0.066622884 0.814507439 1 17.81714329 18.34698635 51204 translational activator of cytochrome c oxidase I "GO:0003729,GO:0005515,GO:0005739,GO:0019843,GO:0033617,GO:0061743,GO:0070129,GO:0097177,GO:1904959" mRNA binding|protein binding|mitochondrion|rRNA binding|mitochondrial cytochrome c oxidase assembly|motor learning|regulation of mitochondrial translation|mitochondrial ribosome binding|regulation of cytochrome-c oxidase activity TACSTD2 418.9325916 425.529278 412.3359051 0.968995382 -0.045438305 0.881839763 1 12.47786565 11.88866777 4070 tumor associated calcium signal transducer 2 "GO:0005515,GO:0005615,GO:0005634,GO:0005829,GO:0007601,GO:0009925,GO:0010633,GO:0016020,GO:0016021,GO:0016328,GO:0050896,GO:0051497,GO:0070062,GO:0090191,GO:1900025,GO:1900028,GO:2000146,GO:2000738" protein binding|extracellular space|nucleus|cytosol|visual perception|basal plasma membrane|negative regulation of epithelial cell migration|membrane|integral component of membrane|lateral plasma membrane|response to stimulus|negative regulation of stress fiber assembly|extracellular exosome|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of substrate adhesion-dependent cell spreading|negative regulation of ruffle assembly|negative regulation of cell motility|positive regulation of stem cell differentiation TADA1 280.2694672 267.3863678 293.1525666 1.096363173 0.132725773 0.688547296 1 6.80816747 7.339320406 117143 transcriptional adaptor 1 "GO:0000124,GO:0003713,GO:0005634,GO:0005654,GO:0005829,GO:0005925,GO:0006357,GO:0030914,GO:0043966,GO:0045893" "SAGA complex|transcription coactivator activity|nucleus|nucleoplasm|cytosol|focal adhesion|regulation of transcription by RNA polymerase II|STAGA complex|histone H3 acetylation|positive regulation of transcription, DNA-templated" TADA2A 325.4928726 344.3769952 306.60875 0.89032878 -0.167589903 0.590264675 1 3.951573273 3.459327109 6871 transcriptional adaptor 2A "GO:0000125,GO:0003677,GO:0003682,GO:0003713,GO:0004402,GO:0005515,GO:0005634,GO:0005694,GO:0006338,GO:0006357,GO:0035066,GO:0043966,GO:0045893,GO:0070461" "PCAF complex|DNA binding|chromatin binding|transcription coactivator activity|histone acetyltransferase activity|protein binding|nucleus|chromosome|chromatin remodeling|regulation of transcription by RNA polymerase II|positive regulation of histone acetylation|histone H3 acetylation|positive regulation of transcription, DNA-templated|SAGA-type complex" TADA2B 423.2081036 449.4587973 396.9574098 0.883189766 -0.179204641 0.532872039 1 4.385153554 3.808114623 93624 transcriptional adaptor 2B "GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006338,GO:0006357,GO:0008270,GO:0016579,GO:0030914,GO:0035066,GO:0045893,GO:0070461" "chromatin binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|chromatin remodeling|regulation of transcription by RNA polymerase II|zinc ion binding|protein deubiquitination|STAGA complex|positive regulation of histone acetylation|positive regulation of transcription, DNA-templated|SAGA-type complex" TADA3 1800.795726 1515.883027 2085.708425 1.375903277 0.460379055 0.052320406 1 26.38613538 35.69725898 10474 transcriptional adaptor 3 "GO:0000124,GO:0000278,GO:0001932,GO:0003713,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005671,GO:0006357,GO:0010628,GO:0016579,GO:0016922,GO:0019904,GO:0030374,GO:0030520,GO:0030914,GO:0031063,GO:0031647,GO:0033276,GO:0043966,GO:0043967,GO:0045893,GO:0072686,GO:0090043" "SAGA complex|mitotic cell cycle|regulation of protein phosphorylation|transcription coactivator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|regulation of transcription by RNA polymerase II|positive regulation of gene expression|protein deubiquitination|nuclear receptor binding|protein domain specific binding|nuclear receptor coactivator activity|intracellular estrogen receptor signaling pathway|STAGA complex|regulation of histone deacetylation|regulation of protein stability|transcription factor TFTC complex|histone H3 acetylation|histone H4 acetylation|positive regulation of transcription, DNA-templated|mitotic spindle|regulation of tubulin deacetylation" hsa05165 Human papillomavirus infection TAF1 1404.467349 1545.014616 1263.920082 0.818063512 -0.289715241 0.22638651 1 10.50644628 8.451115654 6872 TATA-box binding protein associated factor 1 "GO:0000122,GO:0000209,GO:0000785,GO:0000979,GO:0001181,GO:0002039,GO:0004402,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005667,GO:0005669,GO:0005730,GO:0006361,GO:0006366,GO:0006367,GO:0006468,GO:0006511,GO:0006974,GO:0007049,GO:0008134,GO:0010629,GO:0016032,GO:0016251,GO:0016301,GO:0016573,GO:0017025,GO:0018105,GO:0018107,GO:0030901,GO:0032092,GO:0032436,GO:0034644,GO:0035257,GO:0036369,GO:0043433,GO:0043565,GO:0046777,GO:0046982,GO:0050821,GO:0051123,GO:0061628,GO:0061629,GO:0061631,GO:0070577,GO:0071318,GO:0071339,GO:0106310,GO:0106311,GO:0140416,GO:1901796,GO:1902806,GO:1903026,GO:1905502,GO:1905524,GO:2000059,GO:2000825" negative regulation of transcription by RNA polymerase II|protein polyubiquitination|chromatin|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase I general transcription initiation factor activity|p53 binding|histone acetyltransferase activity|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|transcription regulator complex|transcription factor TFIID complex|nucleolus|transcription initiation from RNA polymerase I promoter|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|protein phosphorylation|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|cell cycle|transcription factor binding|negative regulation of gene expression|viral process|RNA polymerase II general transcription initiation factor activity|kinase activity|histone acetylation|TBP-class protein binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|midbrain development|positive regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|cellular response to UV|nuclear hormone receptor binding|transcription factor catabolic process|negative regulation of DNA-binding transcription factor activity|sequence-specific DNA binding|protein autophosphorylation|protein heterodimerization activity|protein stabilization|RNA polymerase II preinitiation complex assembly|H3K27me3 modified histone binding|RNA polymerase II-specific DNA-binding transcription factor binding|ubiquitin conjugating enzyme activity|lysine-acetylated histone binding|cellular response to ATP|MLL1 complex|protein serine kinase activity|protein threonine kinase activity|transcription regulator inhibitor activity|regulation of signal transduction by p53 class mediator|regulation of cell cycle G1/S phase transition|negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding|acetyl-CoA binding|negative regulation of protein autoubiquitination|negative regulation of ubiquitin-dependent protein catabolic process|positive regulation of androgen receptor activity hsa03022 Basal transcription factors other TAF10 1016.148938 976.9486358 1055.34924 1.080250487 0.111365881 0.652505212 1 9.81512672 10.425372 6881 TATA-box binding protein associated factor 10 "GO:0000082,GO:0000125,GO:0003677,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0005737,GO:0006352,GO:0006366,GO:0006367,GO:0006915,GO:0010468,GO:0016251,GO:0016578,GO:0016579,GO:0019899,GO:0030331,GO:0030914,GO:0033276,GO:0034622,GO:0035264,GO:0042802,GO:0043966,GO:0048471,GO:0051101,GO:0070063,GO:0070365,GO:1901796,GO:1990841" "G1/S transition of mitotic cell cycle|PCAF complex|DNA binding|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|cytoplasm|DNA-templated transcription, initiation|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|apoptotic process|regulation of gene expression|RNA polymerase II general transcription initiation factor activity|histone deubiquitination|protein deubiquitination|enzyme binding|estrogen receptor binding|STAGA complex|transcription factor TFTC complex|cellular protein-containing complex assembly|multicellular organism growth|identical protein binding|histone H3 acetylation|perinuclear region of cytoplasm|regulation of DNA binding|RNA polymerase binding|hepatocyte differentiation|regulation of signal transduction by p53 class mediator|promoter-specific chromatin binding" hsa03022 Basal transcription factors TAF11 286.8239518 300.6796121 272.9682915 0.907837713 -0.139493673 0.670366894 1 6.285436064 5.610671113 6882 TATA-box binding protein associated factor 11 "GO:0003713,GO:0005515,GO:0005654,GO:0005669,GO:0005794,GO:0006366,GO:0006367,GO:0008134,GO:0016251,GO:0017025,GO:0042795,GO:0042809,GO:0043923,GO:0045893,GO:0046966,GO:0046982,GO:0047485,GO:0051123,GO:1901796" "transcription coactivator activity|protein binding|nucleoplasm|transcription factor TFIID complex|Golgi apparatus|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription factor binding|RNA polymerase II general transcription initiation factor activity|TBP-class protein binding|snRNA transcription by RNA polymerase II|vitamin D receptor binding|positive regulation by host of viral transcription|positive regulation of transcription, DNA-templated|thyroid hormone receptor binding|protein heterodimerization activity|protein N-terminus binding|RNA polymerase II preinitiation complex assembly|regulation of signal transduction by p53 class mediator" hsa03022 Basal transcription factors TAF12 380.2932389 407.842242 352.7442358 0.864903631 -0.209388701 0.47838716 1 9.484004738 8.065488216 6883 TATA-box binding protein associated factor 12 "GO:0000124,GO:0003677,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0006352,GO:0006366,GO:0006367,GO:0008134,GO:0016251,GO:0017025,GO:0030914,GO:0033276,GO:0043966,GO:0045893,GO:0046695,GO:0046982,GO:0051091,GO:0051123,GO:1901796" "SAGA complex|DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|DNA-templated transcription, initiation|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription factor binding|RNA polymerase II general transcription initiation factor activity|TBP-class protein binding|STAGA complex|transcription factor TFTC complex|histone H3 acetylation|positive regulation of transcription, DNA-templated|SLIK (SAGA-like) complex|protein heterodimerization activity|positive regulation of DNA-binding transcription factor activity|RNA polymerase II preinitiation complex assembly|regulation of signal transduction by p53 class mediator" hsa03022 Basal transcription factors TAF13 414.7715504 316.2858203 513.2572805 1.622764119 0.698453308 0.014881352 0.712638468 20.73660064 33.08751406 6884 TATA-box binding protein associated factor 13 "GO:0003677,GO:0005515,GO:0005654,GO:0005669,GO:0005730,GO:0006352,GO:0006366,GO:0006367,GO:0008022,GO:0016251,GO:0017025,GO:0042795,GO:0046982,GO:1901796" "DNA binding|protein binding|nucleoplasm|transcription factor TFIID complex|nucleolus|DNA-templated transcription, initiation|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|protein C-terminus binding|RNA polymerase II general transcription initiation factor activity|TBP-class protein binding|snRNA transcription by RNA polymerase II|protein heterodimerization activity|regulation of signal transduction by p53 class mediator" hsa03022 Basal transcription factors TAF15 2912.378464 2992.230326 2832.526602 0.946627196 -0.079131725 0.739050111 1 73.86208744 68.74984651 8148 TATA-box binding protein associated factor 15 "GO:0003677,GO:0003712,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006366,GO:0006367,GO:0045893,GO:0046872,GO:0048255,GO:1901796" "DNA binding|transcription coregulator activity|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-templated|metal ion binding|mRNA stabilization|regulation of signal transduction by p53 class mediator" "hsa03022,hsa05202" Basal transcription factors|Transcriptional misregulation in cancer TAF1A 447.9452934 480.6712138 415.219373 0.86383241 -0.211176649 0.454340607 1 5.674085212 4.819439429 9015 "TATA-box binding protein associated factor, RNA polymerase I subunit A" "GO:0000120,GO:0003677,GO:0005515,GO:0005654,GO:0006360,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0015630,GO:0045815" "RNA polymerase I transcription regulator complex|DNA binding|protein binding|nucleoplasm|transcription by RNA polymerase I|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|microtubule cytoskeleton|positive regulation of gene expression, epigenetic" TAF1B 317.1299325 326.6899591 307.5699059 0.941473398 -0.087007764 0.787063119 1 6.586642497 6.097380867 9014 "TATA-box binding protein associated factor, RNA polymerase I subunit B" "GO:0001164,GO:0001188,GO:0005515,GO:0005634,GO:0005654,GO:0005668,GO:0005730,GO:0006351,GO:0006361,GO:0006362,GO:0006363,GO:0017025,GO:0042790,GO:0045815,GO:0046872,GO:0070860" "RNA polymerase I core promoter sequence-specific DNA binding|RNA polymerase I preinitiation complex assembly|protein binding|nucleus|nucleoplasm|RNA polymerase transcription factor SL1 complex|nucleolus|transcription, DNA-templated|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|TBP-class protein binding|nucleolar large rRNA transcription by RNA polymerase I|positive regulation of gene expression, epigenetic|metal ion binding|RNA polymerase I core factor complex" TAF1C 589.4126277 636.7332962 542.0919592 0.851364241 -0.2321516 0.380242155 1 8.168578305 6.838062407 9013 "TATA-box binding protein associated factor, RNA polymerase I subunit C" "GO:0001164,GO:0001181,GO:0001188,GO:0001650,GO:0005515,GO:0005654,GO:0005730,GO:0006360,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0045815" "RNA polymerase I core promoter sequence-specific DNA binding|RNA polymerase I general transcription initiation factor activity|RNA polymerase I preinitiation complex assembly|fibrillar center|protein binding|nucleoplasm|nucleolus|transcription by RNA polymerase I|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|positive regulation of gene expression, epigenetic" TAF1D 1493.993247 1599.116138 1388.870356 0.868523757 -0.203362782 0.394691774 1 52.29282427 44.65755886 79101 "TATA-box binding protein associated factor, RNA polymerase I subunit D" "GO:0003677,GO:0005515,GO:0005654,GO:0005668,GO:0005730,GO:0005829,GO:0006355,GO:0006361,GO:0006362,GO:0006363,GO:0034451,GO:0042802,GO:0045815,GO:0072686" "DNA binding|protein binding|nucleoplasm|RNA polymerase transcription factor SL1 complex|nucleolus|cytosol|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|centriolar satellite|identical protein binding|positive regulation of gene expression, epigenetic|mitotic spindle" TAF2 1804.98069 1764.541945 1845.419436 1.045834836 0.064655031 0.786943139 1 16.73247344 17.20657479 6873 TATA-box binding protein associated factor 2 "GO:0000086,GO:0000976,GO:0003682,GO:0005515,GO:0005654,GO:0005669,GO:0006366,GO:0006367,GO:0014070,GO:0016251,GO:0033276,GO:1901796" G2/M transition of mitotic cell cycle|transcription regulatory region sequence-specific DNA binding|chromatin binding|protein binding|nucleoplasm|transcription factor TFIID complex|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|response to organic cyclic compound|RNA polymerase II general transcription initiation factor activity|transcription factor TFTC complex|regulation of signal transduction by p53 class mediator hsa03022 Basal transcription factors TAF3 240.8721338 242.4164347 239.327833 0.987259108 -0.018499322 0.970118048 1 2.653809144 2.576155142 83860 TATA-box binding protein associated factor 3 "GO:0000122,GO:0002039,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0006366,GO:0006367,GO:0016251,GO:0031965,GO:0043433,GO:0046872,GO:0046982,GO:0051457,GO:0140416,GO:1901796" negative regulation of transcription by RNA polymerase II|p53 binding|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|RNA polymerase II general transcription initiation factor activity|nuclear membrane|negative regulation of DNA-binding transcription factor activity|metal ion binding|protein heterodimerization activity|maintenance of protein location in nucleus|transcription regulator inhibitor activity|regulation of signal transduction by p53 class mediator hsa03022 Basal transcription factors other TAF4 556.1741037 533.7323218 578.6158855 1.084093771 0.116489551 0.66702236 1 6.06178188 6.461574157 6874 TATA-box binding protein associated factor 4 "GO:0000785,GO:0001046,GO:0001541,GO:0003677,GO:0005515,GO:0005654,GO:0005669,GO:0005829,GO:0006352,GO:0006366,GO:0006367,GO:0016032,GO:0016251,GO:0017162,GO:0032991,GO:0033276,GO:0046982,GO:0071339,GO:1901796" "chromatin|core promoter sequence-specific DNA binding|ovarian follicle development|DNA binding|protein binding|nucleoplasm|transcription factor TFIID complex|cytosol|DNA-templated transcription, initiation|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|viral process|RNA polymerase II general transcription initiation factor activity|aryl hydrocarbon receptor binding|protein-containing complex|transcription factor TFTC complex|protein heterodimerization activity|MLL1 complex|regulation of signal transduction by p53 class mediator" "hsa03022,hsa05016" Basal transcription factors|Huntington disease TAF4B 389.979026 422.4080364 357.5500156 0.846456471 -0.240492216 0.411131446 1 4.10696676 3.418196269 6875 TATA-box binding protein associated factor 4b "GO:0001650,GO:0003677,GO:0005654,GO:0005669,GO:0005737,GO:0006366,GO:0006367,GO:0007283,GO:0016251,GO:0046982,GO:0048477,GO:0051059,GO:1901796" fibrillar center|DNA binding|nucleoplasm|transcription factor TFIID complex|cytoplasm|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|spermatogenesis|RNA polymerase II general transcription initiation factor activity|protein heterodimerization activity|oogenesis|NF-kappaB binding|regulation of signal transduction by p53 class mediator "hsa03022,hsa05016" Basal transcription factors|Huntington disease TAF5 469.9575312 516.0452858 423.8697766 0.821380968 -0.283876575 0.306955252 1 8.450564115 6.824982084 6877 TATA-box binding protein associated factor 5 "GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0005730,GO:0006352,GO:0006355,GO:0006366,GO:0006367,GO:0015629,GO:0016032,GO:0016251,GO:0033276,GO:0042795,GO:0042802,GO:0043966,GO:1901796" "chromatin|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|nucleolus|DNA-templated transcription, initiation|regulation of transcription, DNA-templated|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|actin cytoskeleton|viral process|RNA polymerase II general transcription initiation factor activity|transcription factor TFTC complex|snRNA transcription by RNA polymerase II|identical protein binding|histone H3 acetylation|regulation of signal transduction by p53 class mediator" hsa03022 Basal transcription factors TAF5L 744.251857 803.1995174 685.3041966 0.853217889 -0.229013881 0.368145318 1 6.300012055 5.285334905 27097 TATA-box binding protein associated factor 5 like "GO:0003713,GO:0005515,GO:0005634,GO:0006355,GO:0006366,GO:0016607,GO:0030914,GO:0033276,GO:0036464,GO:0043966,GO:0045893,GO:1904672" "transcription coactivator activity|protein binding|nucleus|regulation of transcription, DNA-templated|transcription by RNA polymerase II|nuclear speck|STAGA complex|transcription factor TFTC complex|cytoplasmic ribonucleoprotein granule|histone H3 acetylation|positive regulation of transcription, DNA-templated|regulation of somatic stem cell population maintenance" hsa03022 Basal transcription factors TAF6 1872.360372 1817.603053 1927.117692 1.060252231 0.084407519 0.723147776 1 28.37149293 29.5775749 6878 TATA-box binding protein associated factor 6 "GO:0000124,GO:0003677,GO:0003713,GO:0005515,GO:0005654,GO:0005669,GO:0005829,GO:0006352,GO:0006366,GO:0006367,GO:0006915,GO:0016251,GO:0016573,GO:0017162,GO:0032991,GO:0033276,GO:0042795,GO:0045786,GO:0045944,GO:0046695,GO:0046982,GO:0071339,GO:1901796" "SAGA complex|DNA binding|transcription coactivator activity|protein binding|nucleoplasm|transcription factor TFIID complex|cytosol|DNA-templated transcription, initiation|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|apoptotic process|RNA polymerase II general transcription initiation factor activity|histone acetylation|aryl hydrocarbon receptor binding|protein-containing complex|transcription factor TFTC complex|snRNA transcription by RNA polymerase II|negative regulation of cell cycle|positive regulation of transcription by RNA polymerase II|SLIK (SAGA-like) complex|protein heterodimerization activity|MLL1 complex|regulation of signal transduction by p53 class mediator" hsa03022 Basal transcription factors TAF6L 185.8585314 211.2040182 160.5130447 0.759990487 -0.395946735 0.290979425 1 4.987420475 3.726965037 10629 TATA-box binding protein associated factor 6 like "GO:0000118,GO:0000124,GO:0003677,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0006338,GO:0006355,GO:0006357,GO:0006367,GO:0016251,GO:0016573,GO:0030914,GO:0043966,GO:0045944,GO:0046695,GO:0046982,GO:0070062,GO:1904672" "histone deacetylase complex|SAGA complex|DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|chromatin remodeling|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|RNA polymerase II general transcription initiation factor activity|histone acetylation|STAGA complex|histone H3 acetylation|positive regulation of transcription by RNA polymerase II|SLIK (SAGA-like) complex|protein heterodimerization activity|extracellular exosome|regulation of somatic stem cell population maintenance" hsa03022 Basal transcription factors TAF7 2807.624984 2563.579807 3051.67016 1.190394054 0.251439226 0.287934073 1 59.61374407 69.77636263 6879 TATA-box binding protein associated factor 7 "GO:0000122,GO:0000296,GO:0000976,GO:0001097,GO:0005515,GO:0005654,GO:0005667,GO:0005669,GO:0005737,GO:0006352,GO:0006357,GO:0006366,GO:0006367,GO:0006469,GO:0008134,GO:0016251,GO:0030520,GO:0033276,GO:0035035,GO:0035067,GO:0042809,GO:0045344,GO:0045347,GO:0045892,GO:0045944,GO:0046966,GO:0046982,GO:0051123,GO:0061628,GO:0071339,GO:0090241,GO:0106140,GO:1901796" "negative regulation of transcription by RNA polymerase II|spermine transport|transcription regulatory region sequence-specific DNA binding|TFIIH-class transcription factor complex binding|protein binding|nucleoplasm|transcription regulator complex|transcription factor TFIID complex|cytoplasm|DNA-templated transcription, initiation|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|negative regulation of protein kinase activity|transcription factor binding|RNA polymerase II general transcription initiation factor activity|intracellular estrogen receptor signaling pathway|transcription factor TFTC complex|histone acetyltransferase binding|negative regulation of histone acetylation|vitamin D receptor binding|negative regulation of MHC class I biosynthetic process|negative regulation of MHC class II biosynthetic process|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|thyroid hormone receptor binding|protein heterodimerization activity|RNA polymerase II preinitiation complex assembly|H3K27me3 modified histone binding|MLL1 complex|negative regulation of histone H4 acetylation|P-TEFb complex binding|regulation of signal transduction by p53 class mediator" hsa03022 Basal transcription factors other TAF8 371.9749583 378.7106533 365.2392633 0.964428278 -0.052254142 0.868255335 1 3.24832715 3.080355753 129685 TATA-box binding protein associated factor 8 "GO:0001112,GO:0001833,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0006367,GO:0016251,GO:0030154,GO:0042795,GO:0045598,GO:0046982,GO:0048471,GO:0051457" DNA-templated transcription open complex formation|inner cell mass cell proliferation|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription initiation from RNA polymerase II promoter|RNA polymerase II general transcription initiation factor activity|cell differentiation|snRNA transcription by RNA polymerase II|regulation of fat cell differentiation|protein heterodimerization activity|perinuclear region of cytoplasm|maintenance of protein location in nucleus hsa03022 Basal transcription factors TAF9 1593.126289 1564.782479 1621.470098 1.036227156 0.051340297 0.831554546 1 62.74197219 63.92699848 6880 TATA-box binding protein associated factor 9 "GO:0000124,GO:0000125,GO:0000492,GO:0000976,GO:0002039,GO:0003677,GO:0003713,GO:0004402,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0006366,GO:0006367,GO:0006974,GO:0016251,GO:0030914,GO:0032435,GO:0033276,GO:0033613,GO:0042795,GO:0043066,GO:0043966,GO:0045944,GO:0046982,GO:0050821,GO:0051117,GO:0060760,GO:0070555,GO:0070742,GO:0070761,GO:0071339,GO:1901796,GO:1902166" SAGA complex|PCAF complex|box C/D snoRNP assembly|transcription regulatory region sequence-specific DNA binding|p53 binding|DNA binding|transcription coactivator activity|histone acetyltransferase activity|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|cellular response to DNA damage stimulus|RNA polymerase II general transcription initiation factor activity|STAGA complex|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|transcription factor TFTC complex|activating transcription factor binding|snRNA transcription by RNA polymerase II|negative regulation of apoptotic process|histone H3 acetylation|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|protein stabilization|ATPase binding|positive regulation of response to cytokine stimulus|response to interleukin-1|C2H2 zinc finger domain binding|pre-snoRNP complex|MLL1 complex|regulation of signal transduction by p53 class mediator|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator hsa03022 Basal transcription factors TAF9B 1238.986821 1250.577487 1227.396156 0.981463499 -0.026993481 0.914425114 1 25.11893941 24.2407822 51616 TATA-box binding protein associated factor 9b "GO:0000122,GO:0003714,GO:0005515,GO:0005654,GO:0005669,GO:0006366,GO:0006367,GO:0016251,GO:0016579,GO:0030307,GO:0033276,GO:0043066,GO:0046982,GO:0050821,GO:1901796,GO:1902166" negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleoplasm|transcription factor TFIID complex|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|RNA polymerase II general transcription initiation factor activity|protein deubiquitination|positive regulation of cell growth|transcription factor TFTC complex|negative regulation of apoptotic process|protein heterodimerization activity|protein stabilization|regulation of signal transduction by p53 class mediator|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator hsa03022 Basal transcription factors TAFA2 3.923881751 2.080827765 5.766935736 2.771462315 1.470647391 0.503574097 1 0.024481912 0.066715307 338811 TAFA chemokine like family member 2 "GO:0005615,GO:0005634,GO:0005737,GO:0007165,GO:0007613,GO:0008542,GO:0048018" extracellular space|nucleus|cytoplasm|signal transduction|memory|visual learning|receptor ligand activity TAFA3 59.69043449 53.06110801 66.31976096 1.249875162 0.321784005 0.582595644 1 1.864235558 2.291071292 284467 TAFA chemokine like family member 3 "GO:0005615,GO:0007165,GO:0014016,GO:0048018,GO:1902692,GO:1903979,GO:1903980" extracellular space|signal transduction|neuroblast differentiation|receptor ligand activity|regulation of neuroblast proliferation|negative regulation of microglial cell activation|positive regulation of microglial cell activation TAGAP 3.884252787 1.040413883 6.728091692 6.466745402 2.693039812 0.222326747 1 0.014157312 0.090019736 117289 T cell activation RhoGTPase activating protein "GO:0005085,GO:0005096,GO:0005515,GO:0005829,GO:0007165,GO:0043547,GO:0051056" guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytosol|signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction TAGLN 296.1838751 130.0517353 462.3160148 3.55486233 1.829793689 2.37E-08 2.70E-05 1.629636555 5.696193357 6876 transgelin "GO:0005515,GO:0005737,GO:0007517,GO:0030855,GO:0051015" protein binding|cytoplasm|muscle organ development|epithelial cell differentiation|actin filament binding TAGLN2 8657.697716 7938.357925 9377.037507 1.181231383 0.240291591 0.333082446 1 238.5448043 277.061459 8407 transgelin 2 "GO:0002576,GO:0005515,GO:0005576,GO:0005829,GO:0030855,GO:0031982,GO:0045296,GO:0070062" platelet degranulation|protein binding|extracellular region|cytosol|epithelial cell differentiation|vesicle|cadherin binding|extracellular exosome TAGLN3 213.8515554 113.4051132 314.2979976 2.771462315 1.470647391 4.80E-05 0.020521502 4.644836886 12.65757833 29114 transgelin 3 "GO:0000122,GO:0005634,GO:0007417" negative regulation of transcription by RNA polymerase II|nucleus|central nervous system development TAL1 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.022694132 0.034357474 6886 "TAL bHLH transcription factor 1, erythroid differentiation factor" "GO:0000118,GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001085,GO:0001525,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0006366,GO:0007626,GO:0019899,GO:0021527,GO:0030097,GO:0030218,GO:0030219,GO:0030220,GO:0030221,GO:0031334,GO:0033193,GO:0035162,GO:0035855,GO:0042127,GO:0042826,GO:0043249,GO:0045165,GO:0045647,GO:0045648,GO:0045799,GO:0045893,GO:0045931,GO:0045944,GO:0046983,GO:0051781,GO:0060018,GO:0060216,GO:0060217,GO:0060218,GO:0060375,GO:0061098,GO:0070888,GO:1902036,GO:2000036,GO:2000273" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|angiogenesis|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|locomotory behavior|enzyme binding|spinal cord association neuron differentiation|hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|platelet formation|basophil differentiation|positive regulation of protein-containing complex assembly|Lsd1/2 complex|embryonic hemopoiesis|megakaryocyte development|regulation of cell population proliferation|histone deacetylase binding|erythrocyte maturation|cell fate commitment|negative regulation of erythrocyte differentiation|positive regulation of erythrocyte differentiation|positive regulation of chromatin assembly or disassembly|positive regulation of transcription, DNA-templated|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|protein dimerization activity|positive regulation of cell division|astrocyte fate commitment|definitive hemopoiesis|hemangioblast cell differentiation|hematopoietic stem cell differentiation|regulation of mast cell differentiation|positive regulation of protein tyrosine kinase activity|E-box binding|regulation of hematopoietic stem cell differentiation|regulation of stem cell population maintenance|positive regulation of signaling receptor activity" bHLH TALDO1 5776.464429 5473.617437 6079.311422 1.110656982 0.15141332 0.531158004 1 243.6337802 266.0655423 6888 transaldolase 1 "GO:0004801,GO:0005515,GO:0005622,GO:0005634,GO:0005737,GO:0005829,GO:0005975,GO:0005999,GO:0006002,GO:0006098,GO:0009052,GO:0019682,GO:0035722,GO:0048029,GO:0070062" "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity|protein binding|intracellular anatomical structure|nucleus|cytoplasm|cytosol|carbohydrate metabolic process|xylulose biosynthetic process|fructose 6-phosphate metabolic process|pentose-phosphate shunt|pentose-phosphate shunt, non-oxidative branch|glyceraldehyde-3-phosphate metabolic process|interleukin-12-mediated signaling pathway|monosaccharide binding|extracellular exosome" hsa00030 Pentose phosphate pathway TAMM41 222.1100854 191.4361544 252.7840164 1.320461212 0.401041923 0.252394816 1 1.905725744 2.474327762 132001 TAM41 mitochondrial translocator assembly and maintenance homolog "GO:0004605,GO:0005515,GO:0005743,GO:0016024,GO:0019898,GO:0031314,GO:0032049" phosphatidate cytidylyltransferase activity|protein binding|mitochondrial inner membrane|CDP-diacylglycerol biosynthetic process|extrinsic component of membrane|extrinsic component of mitochondrial inner membrane|cardiolipin biosynthetic process TANC1 1035.772763 1075.787955 995.7575704 0.925607659 -0.111527293 0.651368625 1 6.653473859 6.055452099 85461 "tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1" "GO:0005515,GO:0007520,GO:0008542,GO:0014069,GO:0030425,GO:0043025,GO:0043679,GO:0097062" protein binding|myoblast fusion|visual learning|postsynaptic density|dendrite|neuronal cell body|axon terminus|dendritic spine maintenance TANC2 2321.531706 2734.207684 1908.855729 0.698138528 -0.518414763 0.028456011 0.880398072 7.920084608 5.436790594 26115 "tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2" "GO:0001701,GO:0030424,GO:0043197,GO:0060998,GO:0061001,GO:0099519" in utero embryonic development|axon|dendritic spine|regulation of dendritic spine development|regulation of dendritic spine morphogenesis|dense core granule cytoskeletal transport TANGO2 584.2206191 601.3592242 567.082014 0.943000442 -0.084669648 0.753793416 1 10.92356588 10.12855538 128989 transport and golgi organization 2 homolog "GO:0005794,GO:0007030,GO:0009306" Golgi apparatus|Golgi organization|protein secretion TANGO6 520.4628783 504.6007331 536.3250234 1.062870084 0.087965265 0.75094508 1 5.050565212 5.278266875 79613 transport and golgi organization 6 homolog "GO:0009306,GO:0016021" protein secretion|integral component of membrane TANK 1017.972484 923.8875278 1112.057441 1.203671884 0.267442173 0.276226105 1 16.32114509 19.31656591 10010 TRAF family member associated NFKB activator "GO:0004843,GO:0005515,GO:0005829,GO:0006508,GO:0006974,GO:0007165,GO:0007249,GO:0016032,GO:0018215,GO:0031625,GO:0032991,GO:0035666,GO:0035800,GO:0043124,GO:0046872,GO:0071347,GO:0071356,GO:0071479,GO:1903003,GO:2000158" thiol-dependent ubiquitin-specific protease activity|protein binding|cytosol|proteolysis|cellular response to DNA damage stimulus|signal transduction|I-kappaB kinase/NF-kappaB signaling|viral process|protein phosphopantetheinylation|ubiquitin protein ligase binding|protein-containing complex|TRIF-dependent toll-like receptor signaling pathway|deubiquitinase activator activity|negative regulation of I-kappaB kinase/NF-kappaB signaling|metal ion binding|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to ionizing radiation|positive regulation of protein deubiquitination|positive regulation of ubiquitin-specific protease activity "hsa04140,hsa04621,hsa04622,hsa05014,hsa05022" Autophagy - animal|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases TAOK1 4525.205993 4960.693392 4089.718593 0.824424787 -0.278540214 0.244098509 1 20.93989472 16.97448916 57551 TAO kinase 1 "GO:0000165,GO:0000187,GO:0000226,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006281,GO:0006468,GO:0006974,GO:0007026,GO:0007095,GO:0007165,GO:0007257,GO:0015630,GO:0016301,GO:0016310,GO:0016740,GO:0031098,GO:0032147,GO:0032874,GO:0032956,GO:0043014,GO:0043539,GO:0046330,GO:0046777,GO:0048156,GO:0048471,GO:0048487,GO:0048812,GO:0050321,GO:0051493,GO:0070050,GO:0070062,GO:0070507,GO:0097194,GO:0106310,GO:0106311,GO:1901985" MAPK cascade|activation of MAPK activity|microtubule cytoskeleton organization|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytosol|DNA repair|protein phosphorylation|cellular response to DNA damage stimulus|negative regulation of microtubule depolymerization|mitotic G2 DNA damage checkpoint|signal transduction|activation of JUN kinase activity|microtubule cytoskeleton|kinase activity|phosphorylation|transferase activity|stress-activated protein kinase signaling cascade|activation of protein kinase activity|positive regulation of stress-activated MAPK cascade|regulation of actin cytoskeleton organization|alpha-tubulin binding|protein serine/threonine kinase activator activity|positive regulation of JNK cascade|protein autophosphorylation|tau protein binding|perinuclear region of cytoplasm|beta-tubulin binding|neuron projection morphogenesis|tau-protein kinase activity|regulation of cytoskeleton organization|neuron cellular homeostasis|extracellular exosome|regulation of microtubule cytoskeleton organization|execution phase of apoptosis|protein serine kinase activity|protein threonine kinase activity|positive regulation of protein acetylation hsa04010 MAPK signaling pathway TAOK2 1562.622163 1533.570063 1591.674263 1.037888194 0.053651038 0.824145566 1 12.70077835 12.96140519 9344 TAO kinase 2 "GO:0000165,GO:0000186,GO:0000187,GO:0001558,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006612,GO:0006915,GO:0006974,GO:0007095,GO:0007165,GO:0007409,GO:0008360,GO:0015629,GO:0016021,GO:0016477,GO:0030036,GO:0030424,GO:0030659,GO:0031098,GO:0031410,GO:0031434,GO:0031954,GO:0032147,GO:0032874,GO:0032956,GO:0038191,GO:0043005,GO:0043235,GO:0044294,GO:0044295,GO:0046330,GO:0046777,GO:0048041,GO:0048156,GO:0048812,GO:0050321,GO:0051403,GO:0106310,GO:0106311,GO:0150019,GO:0150020" MAPK cascade|activation of MAPKK activity|activation of MAPK activity|regulation of cell growth|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|nucleoplasm|nucleolus|cytoplasm|cytosol|protein targeting to membrane|apoptotic process|cellular response to DNA damage stimulus|mitotic G2 DNA damage checkpoint|signal transduction|axonogenesis|regulation of cell shape|actin cytoskeleton|integral component of membrane|cell migration|actin cytoskeleton organization|axon|cytoplasmic vesicle membrane|stress-activated protein kinase signaling cascade|cytoplasmic vesicle|mitogen-activated protein kinase kinase binding|positive regulation of protein autophosphorylation|activation of protein kinase activity|positive regulation of stress-activated MAPK cascade|regulation of actin cytoskeleton organization|neuropilin binding|neuron projection|receptor complex|dendritic growth cone|axonal growth cone|positive regulation of JNK cascade|protein autophosphorylation|focal adhesion assembly|tau protein binding|neuron projection morphogenesis|tau-protein kinase activity|stress-activated MAPK cascade|protein serine kinase activity|protein threonine kinase activity|basal dendrite morphogenesis|basal dendrite arborization hsa04010 MAPK signaling pathway TAOK3 1790.122402 1765.582359 1814.662445 1.027798242 0.03955709 0.869737218 1 15.11483566 15.27504431 51347 TAO kinase 3 "GO:0000165,GO:0004674,GO:0004860,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0006281,GO:0006468,GO:0006469,GO:0006974,GO:0007095,GO:0007165,GO:0016740,GO:0031098,GO:0032147,GO:0032874,GO:0043507,GO:0046329,GO:0046330,GO:0046777,GO:0048812,GO:0106310,GO:0106311" MAPK cascade|protein serine/threonine kinase activity|protein kinase inhibitor activity|protein binding|ATP binding|cytoplasm|plasma membrane|DNA repair|protein phosphorylation|negative regulation of protein kinase activity|cellular response to DNA damage stimulus|mitotic G2 DNA damage checkpoint|signal transduction|transferase activity|stress-activated protein kinase signaling cascade|activation of protein kinase activity|positive regulation of stress-activated MAPK cascade|positive regulation of JUN kinase activity|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation|neuron projection morphogenesis|protein serine kinase activity|protein threonine kinase activity hsa04010 MAPK signaling pathway TAP1 719.0642717 697.0773014 741.0512421 1.063083306 0.088254655 0.733604464 1 13.0440864 13.63490585 6890 "transporter 1, ATP binding cassette subfamily B member" "GO:0002250,GO:0002474,GO:0002479,GO:0005515,GO:0005524,GO:0005783,GO:0005789,GO:0006952,GO:0015031,GO:0015433,GO:0015440,GO:0015833,GO:0016020,GO:0016021,GO:0016032,GO:0016887,GO:0019885,GO:0023029,GO:0030176,GO:0030670,GO:0033116,GO:0034451,GO:0042288,GO:0042605,GO:0042626,GO:0042803,GO:0042824,GO:0042825,GO:0043531,GO:0046967,GO:0046978,GO:0046979,GO:0055085,GO:0098656,GO:1904680,GO:1990668" "adaptive immune response|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|ATP binding|endoplasmic reticulum|endoplasmic reticulum membrane|defense response|protein transport|ATPase-coupled peptide antigen transmembrane transporter activity|ATPase-coupled peptide transmembrane transporter activity|peptide transport|membrane|integral component of membrane|viral process|ATPase activity|antigen processing and presentation of endogenous peptide antigen via MHC class I|MHC class Ib protein binding|integral component of endoplasmic reticulum membrane|phagocytic vesicle membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|centriolar satellite|MHC class I protein binding|peptide antigen binding|ATPase-coupled transmembrane transporter activity|protein homodimerization activity|MHC class I peptide loading complex|TAP complex|ADP binding|cytosol to endoplasmic reticulum transport|TAP1 binding|TAP2 binding|transmembrane transport|anion transmembrane transport|peptide transmembrane transporter activity|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane" "hsa02010,hsa04145,hsa04612,hsa05163,hsa05168,hsa05169,hsa05170,hsa05340" ABC transporters|Phagosome|Antigen processing and presentation|Human cytomegalovirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Primary immunodeficiency TAP2 776.4499672 904.119664 648.7802703 0.717582303 -0.478783785 0.057916297 1 7.870038292 5.552898604 6891 "transporter 2, ATP binding cassette subfamily B member" "GO:0002250,GO:0002474,GO:0002479,GO:0002489,GO:0005515,GO:0005524,GO:0005783,GO:0005789,GO:0015031,GO:0015433,GO:0015440,GO:0015833,GO:0016020,GO:0016021,GO:0016032,GO:0016607,GO:0016887,GO:0019885,GO:0023029,GO:0030176,GO:0030670,GO:0033116,GO:0042288,GO:0042605,GO:0042626,GO:0042824,GO:0042825,GO:0046967,GO:0046968,GO:0046978,GO:0046980,GO:0055085,GO:0098656,GO:1904680,GO:1990668" "adaptive immune response|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|protein binding|ATP binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein transport|ATPase-coupled peptide antigen transmembrane transporter activity|ATPase-coupled peptide transmembrane transporter activity|peptide transport|membrane|integral component of membrane|viral process|nuclear speck|ATPase activity|antigen processing and presentation of endogenous peptide antigen via MHC class I|MHC class Ib protein binding|integral component of endoplasmic reticulum membrane|phagocytic vesicle membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|MHC class I protein binding|peptide antigen binding|ATPase-coupled transmembrane transporter activity|MHC class I peptide loading complex|TAP complex|cytosol to endoplasmic reticulum transport|peptide antigen transport|TAP1 binding|tapasin binding|transmembrane transport|anion transmembrane transport|peptide transmembrane transporter activity|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane" "hsa02010,hsa04145,hsa04612,hsa05163,hsa05168,hsa05169,hsa05170,hsa05340" ABC transporters|Phagosome|Antigen processing and presentation|Human cytomegalovirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Primary immunodeficiency TAPBP 1475.865262 1564.782479 1386.948044 0.886351977 -0.174048377 0.466925579 1 21.98198604 19.15774217 6892 TAP binding protein "GO:0000139,GO:0002398,GO:0002474,GO:0002479,GO:0005515,GO:0005783,GO:0005789,GO:0006890,GO:0006955,GO:0010468,GO:0015433,GO:0015833,GO:0016021,GO:0019885,GO:0030670,GO:0033116,GO:0042288,GO:0042605,GO:0042824,GO:0046978,GO:0046979,GO:0050823,GO:0051082,GO:0061635,GO:0062061,GO:0065003,GO:0071556,GO:1990668" "Golgi membrane|MHC class Ib protein complex assembly|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|immune response|regulation of gene expression|ATPase-coupled peptide antigen transmembrane transporter activity|peptide transport|integral component of membrane|antigen processing and presentation of endogenous peptide antigen via MHC class I|phagocytic vesicle membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|MHC class I protein binding|peptide antigen binding|MHC class I peptide loading complex|TAP1 binding|TAP2 binding|peptide antigen stabilization|unfolded protein binding|regulation of protein complex stability|TAP complex binding|protein-containing complex assembly|integral component of lumenal side of endoplasmic reticulum membrane|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane" "hsa04612,hsa05163,hsa05168,hsa05169,hsa05170" Antigen processing and presentation|Human cytomegalovirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection TAPBPL 127.2135412 147.7387713 106.6883111 0.722141589 -0.469646363 0.276657443 1 2.70853545 1.923215985 55080 TAP binding protein like "GO:0000139,GO:0002502,GO:0002590,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0016021,GO:0023024" Golgi membrane|peptide antigen assembly with MHC class I protein complex|negative regulation of antigen processing and presentation of peptide antigen via MHC class I|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of membrane|MHC class I protein complex binding TAPT1 419.5024883 402.6401726 436.364804 1.083758735 0.116043621 0.690269081 1 4.56224331 4.861633684 202018 transmembrane anterior posterior transformation 1 "GO:0001503,GO:0005813,GO:0007186,GO:0014032,GO:0016021,GO:0016032,GO:0016520,GO:0030030,GO:0030176,GO:0035437,GO:0036064,GO:0045724,GO:0048706,GO:0051216,GO:0061036,GO:1903012" ossification|centrosome|G protein-coupled receptor signaling pathway|neural crest cell development|integral component of membrane|viral process|growth hormone-releasing hormone receptor activity|cell projection organization|integral component of endoplasmic reticulum membrane|maintenance of protein localization in endoplasmic reticulum|ciliary basal body|positive regulation of cilium assembly|embryonic skeletal system development|cartilage development|positive regulation of cartilage development|positive regulation of bone development TARBP1 658.4020061 769.9062732 546.897739 0.710343269 -0.493411728 0.056350479 1 7.740859603 5.406654761 6894 TAR (HIV-1) RNA binding protein 1 "GO:0003723,GO:0005634,GO:0006357,GO:0016423,GO:0030488" RNA binding|nucleus|regulation of transcription by RNA polymerase II|tRNA (guanine) methyltransferase activity|tRNA methylation TARBP2 291.1095246 299.6391982 282.5798511 0.943067038 -0.084567767 0.79933517 1 8.908742782 8.260953245 6895 TARBP2 subunit of RISC loading complex "GO:0003725,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006469,GO:0007286,GO:0007338,GO:0010586,GO:0016442,GO:0016604,GO:0019899,GO:0030422,GO:0030423,GO:0031054,GO:0035087,GO:0035196,GO:0035197,GO:0035198,GO:0035264,GO:0035280,GO:0036002,GO:0042802,GO:0042803,GO:0043403,GO:0045070,GO:0045727,GO:0046782,GO:0047485,GO:0048471,GO:0050689,GO:0051149,GO:0061351,GO:0070578,GO:0070883,GO:0090065,GO:1903798" double-stranded RNA binding|protein binding|nucleoplasm|cytoplasm|cytosol|negative regulation of protein kinase activity|spermatid development|single fertilization|miRNA metabolic process|RISC complex|nuclear body|enzyme binding|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|pre-miRNA processing|siRNA loading onto RISC involved in RNA interference|production of miRNAs involved in gene silencing by miRNA|siRNA binding|miRNA binding|multicellular organism growth|miRNA loading onto RISC involved in gene silencing by miRNA|pre-mRNA binding|identical protein binding|protein homodimerization activity|skeletal muscle tissue regeneration|positive regulation of viral genome replication|positive regulation of translation|regulation of viral transcription|protein N-terminus binding|perinuclear region of cytoplasm|negative regulation of defense response to virus by host|positive regulation of muscle cell differentiation|neural precursor cell proliferation|RISC-loading complex|pre-miRNA binding|regulation of production of siRNA involved in RNA interference|regulation of production of miRNAs involved in gene silencing by miRNA TARDBP 3139.305619 2956.856254 3321.754984 1.123407666 0.167881553 0.478822526 1 36.44387617 40.25623217 23435 TAR DNA binding protein "GO:0000978,GO:0001933,GO:0003690,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005654,GO:0005726,GO:0006397,GO:0008380,GO:0010468,GO:0010494,GO:0010629,GO:0016607,GO:0031647,GO:0032024,GO:0034976,GO:0035061,GO:0042307,GO:0042752,GO:0042802,GO:0042981,GO:0043922,GO:0048511,GO:0051726,GO:0061158,GO:0070935,GO:0071765,GO:0097157" RNA polymerase II cis-regulatory region sequence-specific DNA binding|negative regulation of protein phosphorylation|double-stranded DNA binding|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|nucleoplasm|perichromatin fibrils|mRNA processing|RNA splicing|regulation of gene expression|cytoplasmic stress granule|negative regulation of gene expression|nuclear speck|regulation of protein stability|positive regulation of insulin secretion|response to endoplasmic reticulum stress|interchromatin granule|positive regulation of protein import into nucleus|regulation of circadian rhythm|identical protein binding|regulation of apoptotic process|negative regulation by host of viral transcription|rhythmic process|regulation of cell cycle|3'-UTR-mediated mRNA destabilization|3'-UTR-mediated mRNA stabilization|nuclear inner membrane organization|pre-mRNA intronic binding "hsa03013,hsa03015,hsa05014,hsa05022" RNA transport|mRNA surveillance pathway|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases TARS1 6962.634291 7204.866137 6720.402444 0.932758821 -0.100423996 0.681301721 1 134.1159622 123.0045038 6897 threonyl-tRNA synthetase 1 "GO:0000049,GO:0004829,GO:0005515,GO:0005524,GO:0005829,GO:0006418,GO:0006435,GO:0008270,GO:0042802,GO:0070062" tRNA binding|threonine-tRNA ligase activity|protein binding|ATP binding|cytosol|tRNA aminoacylation for protein translation|threonyl-tRNA aminoacylation|zinc ion binding|identical protein binding|extracellular exosome hsa00970 Aminoacyl-tRNA biosynthesis TARS2 873.8538113 887.4730419 860.2345806 0.969307844 -0.044973169 0.861070973 1 17.31729621 16.50490357 80222 "threonyl-tRNA synthetase 2, mitochondrial" "GO:0002161,GO:0004829,GO:0005515,GO:0005524,GO:0005575,GO:0005759,GO:0006435,GO:0042803,GO:0070159,GO:0106074" aminoacyl-tRNA editing activity|threonine-tRNA ligase activity|protein binding|ATP binding|cellular_component|mitochondrial matrix|threonyl-tRNA aminoacylation|protein homodimerization activity|mitochondrial threonyl-tRNA aminoacylation|aminoacyl-tRNA metabolism involved in translational fidelity hsa00970 Aminoacyl-tRNA biosynthesis TARS3 190.8328879 190.3957405 191.2700352 1.004591987 0.006609672 1 1 2.174886716 2.148312864 123283 threonyl-tRNA synthetase 3 "GO:0003674,GO:0004829,GO:0005515,GO:0005524,GO:0005575,GO:0005634,GO:0005737,GO:0006435,GO:0008150" molecular_function|threonine-tRNA ligase activity|protein binding|ATP binding|cellular_component|nucleus|cytoplasm|threonyl-tRNA aminoacylation|biological_process hsa00970 Aminoacyl-tRNA biosynthesis TAS2R10 3.364045846 0 6.728091692 Inf Inf 0.085118512 1 0 0.38209676 50839 taste 2 receptor member 10 "GO:0001580,GO:0004930,GO:0005515,GO:0005886,GO:0007186,GO:0008527,GO:0016021,GO:0033038" detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|protein binding|plasma membrane|G protein-coupled receptor signaling pathway|taste receptor activity|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TAS2R14 5.524131538 6.242483296 4.80577978 0.769850643 -0.377349516 0.927604977 1 0.34921369 0.264343671 50840 taste 2 receptor member 14 "GO:0001580,GO:0004930,GO:0005886,GO:0007186,GO:0008527,GO:0016021,GO:0033038" detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|taste receptor activity|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TAS2R19 5.484502575 5.202069413 5.766935736 1.108584926 0.148719296 1 1 0.277070742 0.302016601 259294 taste 2 receptor member 19 "GO:0001580,GO:0004930,GO:0005515,GO:0005886,GO:0007186,GO:0016021,GO:0033038" detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|protein binding|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TAS2R20 25.13850987 29.13158871 21.14543103 0.725859178 -0.462238413 0.576863127 1 0.66326764 0.473382676 259295 taste 2 receptor member 20 "GO:0001580,GO:0004930,GO:0005886,GO:0007186,GO:0016021,GO:0033038" detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TAS2R3 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.151294214 0.045809966 50831 taste 2 receptor member 3 "GO:0001580,GO:0004930,GO:0005886,GO:0007186,GO:0008527,GO:0016021,GO:0033038" detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|taste receptor activity|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TAS2R31 4.92466667 3.121241648 6.728091692 2.155581801 1.108077311 0.568402303 1 0.163148805 0.345795697 259290 taste 2 receptor member 31 "GO:0001580,GO:0004930,GO:0005886,GO:0007186,GO:0016021,GO:0033038" detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TAS2R38 3.041983721 4.161655531 1.922311912 0.461910386 -1.11431511 0.721843574 1 0.194313129 0.08825332 5726 taste 2 receptor member 38 "GO:0001580,GO:0004930,GO:0005886,GO:0007186,GO:0016021,GO:0033038" detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TAS2R4 9.527271215 10.40413883 8.650403604 0.831438695 -0.266318203 0.910300494 1 0.110651608 0.090460532 50832 taste 2 receptor member 4 "GO:0001580,GO:0004930,GO:0005886,GO:0007186,GO:0007585,GO:0008527,GO:0016021,GO:0033038,GO:0060170" detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|respiratory gaseous exchange by respiratory system|taste receptor activity|integral component of membrane|bitter taste receptor activity|ciliary membrane hsa04742 Taste transduction TAS2R5 5.524131538 6.242483296 4.80577978 0.769850643 -0.377349516 0.927604977 1 0.28944384 0.219099793 54429 taste 2 receptor member 5 "GO:0001580,GO:0004930,GO:0005515,GO:0005886,GO:0007186,GO:0007635,GO:0008527,GO:0016021,GO:0033038" detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|protein binding|plasma membrane|G protein-coupled receptor signaling pathway|chemosensory behavior|taste receptor activity|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TASOR 2691.403756 2666.580781 2716.226732 1.018617831 0.026612877 0.911972433 1 17.61268754 17.64038598 23272 transcription activation suppressor "GO:0000792,GO:0001701,GO:0003682,GO:0003723,GO:0005515,GO:0005654,GO:0008595,GO:0045814,GO:0045869,GO:0060809,GO:0090307,GO:0090309,GO:0097355" "heterochromatin|in utero embryonic development|chromatin binding|RNA binding|protein binding|nucleoplasm|anterior/posterior axis specification, embryo|negative regulation of gene expression, epigenetic|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|mesodermal to mesenchymal transition involved in gastrulation|mitotic spindle assembly|positive regulation of DNA methylation-dependent heterochromatin assembly|protein localization to heterochromatin" TASOR2 1565.469189 1822.805122 1308.133256 0.717648442 -0.478650818 0.044558021 1 5.823391751 4.109215635 54906 transcription activation suppressor family member 2 "GO:0005515,GO:0005654,GO:0005829" protein binding|nucleoplasm|cytosol TASP1 142.7901813 152.9408407 132.6395219 0.867260316 -0.205462998 0.628778967 1 2.711684909 2.312383583 55617 taspase 1 "GO:0004298,GO:0005737,GO:0006508,GO:0042802,GO:0045893,GO:0051604" "threonine-type endopeptidase activity|cytoplasm|proteolysis|identical protein binding|positive regulation of transcription, DNA-templated|protein maturation" TATDN1 529.1378196 543.0960467 515.1795924 0.948597574 -0.076131916 0.783666313 1 21.99092401 20.51146433 83940 TatD DNase domain containing 1 "GO:0005515,GO:0005654,GO:0006259,GO:0008296,GO:0016888,GO:0046872,GO:0090305" "protein binding|nucleoplasm|DNA metabolic process|3'-5'-exodeoxyribonuclease activity|endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|nucleic acid phosphodiester bond hydrolysis" TATDN2 1197.409895 1168.38479 1226.435 1.049684154 0.069955291 0.775449585 1 12.63004838 13.03571431 9797 TatD DNase domain containing 2 "GO:0005654,GO:0006259,GO:0016888,GO:0036498,GO:0046872,GO:0090305" "nucleoplasm|DNA metabolic process|endodeoxyribonuclease activity, producing 5'-phosphomonoesters|IRE1-mediated unfolded protein response|metal ion binding|nucleic acid phosphodiester bond hydrolysis" TATDN3 258.8912928 248.658918 269.1236677 1.082300486 0.114101099 0.739429274 1 4.973939069 5.293214491 128387 TatD DNase domain containing 3 "GO:0004518,GO:0005634,GO:0046872,GO:0090305" nuclease activity|nucleus|metal ion binding|nucleic acid phosphodiester bond hydrolysis TAX1BP1 2927.851923 2855.936108 2999.767739 1.050362342 0.070887098 0.765584445 1 43.860737 45.29875296 8887 Tax1 binding protein 1 "GO:0005515,GO:0005829,GO:0006915,GO:0010803,GO:0019900,GO:0032088,GO:0032480,GO:0043066,GO:0046872,GO:0070062" protein binding|cytosol|apoptotic process|regulation of tumor necrosis factor-mediated signaling pathway|kinase binding|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of apoptotic process|metal ion binding|extracellular exosome hsa04137 Mitophagy - animal TAX1BP3 1539.258124 1374.386739 1704.12951 1.239919931 0.31024696 0.193143636 1 57.30351113 69.86281047 30851 Tax1 binding protein 3 "GO:0001650,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007266,GO:0008013,GO:0008022,GO:0008285,GO:0015629,GO:0016055,GO:0030178,GO:0043231,GO:0070062,GO:0090630,GO:2000009" fibrillar center|protein binding|cytoplasm|cytosol|plasma membrane|Rho protein signal transduction|beta-catenin binding|protein C-terminus binding|negative regulation of cell population proliferation|actin cytoskeleton|Wnt signaling pathway|negative regulation of Wnt signaling pathway|intracellular membrane-bounded organelle|extracellular exosome|activation of GTPase activity|negative regulation of protein localization to cell surface TAZ 978.7928032 955.0999443 1002.485662 1.04961336 0.069857989 0.780103059 1 18.34842643 18.93648437 6901 tafazzin "GO:0003841,GO:0005739,GO:0005743,GO:0006936,GO:0007007,GO:0007507,GO:0007519,GO:0008374,GO:0016021,GO:0030097,GO:0031966,GO:0032049,GO:0032981,GO:0035965,GO:0042407,GO:0042775,GO:0047184,GO:0048738,GO:0060048" 1-acylglycerol-3-phosphate O-acyltransferase activity|mitochondrion|mitochondrial inner membrane|muscle contraction|inner mitochondrial membrane organization|heart development|skeletal muscle tissue development|O-acyltransferase activity|integral component of membrane|hemopoiesis|mitochondrial membrane|cardiolipin biosynthetic process|mitochondrial respiratory chain complex I assembly|cardiolipin acyl-chain remodeling|cristae formation|mitochondrial ATP synthesis coupled electron transport|1-acylglycerophosphocholine O-acyltransferase activity|cardiac muscle tissue development|cardiac muscle contraction hsa00564 Glycerophospholipid metabolism other TBC1D1 3072.723547 2912.118458 3233.328636 1.110301206 0.150951109 0.52425512 1 19.81568403 21.63321461 23216 TBC1 domain family member 1 "GO:0005096,GO:0005515,GO:0005634,GO:0005829,GO:0006886,GO:0032880,GO:0061024,GO:0090630,GO:1902017" GTPase activator activity|protein binding|nucleus|cytosol|intracellular protein transport|regulation of protein localization|membrane organization|activation of GTPase activity|regulation of cilium assembly hsa04152 AMPK signaling pathway TBC1D10A 551.2890659 531.651494 570.9266379 1.073873852 0.10282453 0.705528044 1 14.23645916 15.03233456 83874 TBC1 domain family member 10A "GO:0005085,GO:0005096,GO:0005515,GO:0005829,GO:0005886,GO:0005902,GO:0006886,GO:0030165,GO:0042147,GO:0045296,GO:0045862,GO:0070062,GO:0090630,GO:0097202,GO:1902017" "guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytosol|plasma membrane|microvillus|intracellular protein transport|PDZ domain binding|retrograde transport, endosome to Golgi|cadherin binding|positive regulation of proteolysis|extracellular exosome|activation of GTPase activity|activation of cysteine-type endopeptidase activity|regulation of cilium assembly" TBC1D10B 1223.876282 1181.910171 1265.842394 1.071014046 0.098977401 0.684436401 1 17.7980738 18.7430105 26000 TBC1 domain family member 10B "GO:0005096,GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0042147,GO:0043087,GO:0090630,GO:1902017" "GTPase activator activity|protein binding|cytosol|plasma membrane|intracellular protein transport|retrograde transport, endosome to Golgi|regulation of GTPase activity|activation of GTPase activity|regulation of cilium assembly" TBC1D12 1392.578046 1333.810598 1451.345494 1.08811963 0.121837178 0.612663582 1 12.44893672 13.31925958 23232 TBC1 domain family member 12 "GO:0005096,GO:0005776,GO:0006886,GO:0055037,GO:0090630,GO:2000785" GTPase activator activity|autophagosome|intracellular protein transport|recycling endosome|activation of GTPase activity|regulation of autophagosome assembly TBC1D13 872.2780992 921.8067 822.7494983 0.892540159 -0.164011012 0.512085373 1 12.7547652 11.19364199 54662 TBC1 domain family member 13 "GO:0005096,GO:0005515,GO:0005829,GO:0006886,GO:0016020,GO:0090630,GO:1902017" GTPase activator activity|protein binding|cytosol|intracellular protein transport|membrane|activation of GTPase activity|regulation of cilium assembly TBC1D14 1801.903494 1847.775056 1756.031932 0.950349409 -0.073470058 0.758380468 1 16.44635735 15.36824268 57533 TBC1 domain family member 14 "GO:0005096,GO:0005515,GO:0005654,GO:0005776,GO:0005794,GO:0005829,GO:0006886,GO:0006914,GO:0010507,GO:0019901,GO:0043231,GO:0055037,GO:0071955,GO:0090630,GO:1902017,GO:2000785" GTPase activator activity|protein binding|nucleoplasm|autophagosome|Golgi apparatus|cytosol|intracellular protein transport|autophagy|negative regulation of autophagy|protein kinase binding|intracellular membrane-bounded organelle|recycling endosome|recycling endosome to Golgi transport|activation of GTPase activity|regulation of cilium assembly|regulation of autophagosome assembly TBC1D15 1319.80318 1252.658315 1386.948044 1.107203799 0.146920798 0.542430192 1 17.83197438 19.41324687 64786 TBC1 domain family member 15 "GO:0005096,GO:0005515,GO:0005576,GO:0005737,GO:0006886,GO:0043087,GO:0090630,GO:1902017" GTPase activator activity|protein binding|extracellular region|cytoplasm|intracellular protein transport|regulation of GTPase activity|activation of GTPase activity|regulation of cilium assembly hsa04137 Mitophagy - animal TBC1D16 1654.866754 1797.835189 1511.898319 0.840954904 -0.249899657 0.293206774 1 7.335970622 6.06598692 125058 TBC1 domain family member 16 "GO:0001919,GO:0005096,GO:0005515,GO:0005769,GO:0005829,GO:0006886,GO:0090630,GO:1902017" regulation of receptor recycling|GTPase activator activity|protein binding|early endosome|cytosol|intracellular protein transport|activation of GTPase activity|regulation of cilium assembly TBC1D17 546.200853 536.8535634 555.5481426 1.034822492 0.049383317 0.860350853 1 9.91723364 10.09084611 79735 TBC1 domain family member 17 "GO:0005096,GO:0005515,GO:0005776,GO:0005829,GO:0006886,GO:0006914,GO:0042147,GO:0055037,GO:0090630,GO:1902017" "GTPase activator activity|protein binding|autophagosome|cytosol|intracellular protein transport|autophagy|retrograde transport, endosome to Golgi|recycling endosome|activation of GTPase activity|regulation of cilium assembly" hsa04137 Mitophagy - animal TBC1D19 253.3426236 203.921121 302.7641261 1.484711955 0.570183064 0.08739557 1 1.981229826 2.892332659 55296 TBC1 domain family member 19 "GO:0005096,GO:0005515,GO:0043547,GO:1902017" GTPase activator activity|protein binding|positive regulation of GTPase activity|regulation of cilium assembly TBC1D2 2590.46729 2704.035681 2476.898899 0.916000819 -0.126579207 0.593048682 1 22.04880282 19.85875667 55357 TBC1 domain family member 2 "GO:0005096,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006886,GO:0030054,GO:0031410,GO:0043547,GO:0045296,GO:0090630,GO:1902017" GTPase activator activity|protein binding|nucleoplasm|cytosol|plasma membrane|intracellular protein transport|cell junction|cytoplasmic vesicle|positive regulation of GTPase activity|cadherin binding|activation of GTPase activity|regulation of cilium assembly TBC1D20 1119.165003 1145.495685 1092.834322 0.954027445 -0.067897325 0.783317306 1 17.60743069 16.51688081 128637 TBC1 domain family member 20 "GO:0005096,GO:0005515,GO:0005783,GO:0005789,GO:0006888,GO:0007030,GO:0019068,GO:0030173,GO:0031267,GO:0031965,GO:0033116,GO:0043547,GO:0044829,GO:0046726,GO:0048208,GO:0090110,GO:1902017,GO:1902953" GTPase activator activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|virion assembly|integral component of Golgi membrane|small GTPase binding|nuclear membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|positive regulation of GTPase activity|positive regulation by host of viral genome replication|positive regulation by virus of viral protein levels in host cell|COPII vesicle coating|COPII-coated vesicle cargo loading|regulation of cilium assembly|positive regulation of ER to Golgi vesicle-mediated transport TBC1D22A 607.6752052 535.8131496 679.5372609 1.268235506 0.342822673 0.191516646 1 2.702775332 3.370396792 25771 TBC1 domain family member 22A "GO:0005096,GO:0005515,GO:0006886,GO:0042803,GO:0071889,GO:0090630,GO:1902017" GTPase activator activity|protein binding|intracellular protein transport|protein homodimerization activity|14-3-3 protein binding|activation of GTPase activity|regulation of cilium assembly TBC1D22B 432.7800342 448.4183834 417.1416849 0.930251079 -0.104307937 0.718597129 1 6.214298874 5.684123398 55633 TBC1 domain family member 22B "GO:0005096,GO:0005515,GO:0006886,GO:0071889,GO:0090630,GO:1902017" GTPase activator activity|protein binding|intracellular protein transport|14-3-3 protein binding|activation of GTPase activity|regulation of cilium assembly TBC1D23 1374.777153 1282.830317 1466.723989 1.143349958 0.193267053 0.420953817 1 17.94555604 20.17470894 55773 TBC1 domain family member 23 "GO:0005515,GO:0005794,GO:0005802,GO:0005829,GO:0007420,GO:0016192,GO:0031175,GO:0031410,GO:0042147,GO:0071203,GO:0099041,GO:1990403" "protein binding|Golgi apparatus|trans-Golgi network|cytosol|brain development|vesicle-mediated transport|neuron projection development|cytoplasmic vesicle|retrograde transport, endosome to Golgi|WASH complex|vesicle tethering to Golgi|embryonic brain development" TBC1D24 336.9770542 368.3065145 305.647594 0.829872897 -0.269037705 0.377729638 1 2.895248455 2.362482488 57465 TBC1 domain family member 24 "GO:0005096,GO:0005515,GO:0005737,GO:0005886,GO:0030054,GO:0030659,GO:0031175,GO:0031594,GO:0036475,GO:0043195,GO:0043547,GO:1902017" GTPase activator activity|protein binding|cytoplasm|plasma membrane|cell junction|cytoplasmic vesicle membrane|neuron projection development|neuromuscular junction|neuron death in response to oxidative stress|terminal bouton|positive regulation of GTPase activity|regulation of cilium assembly TBC1D25 610.865644 569.1063938 652.6248941 1.146753755 0.197555632 0.453021822 1 7.923861796 8.934664345 4943 TBC1 domain family member 25 "GO:0005096,GO:0005515,GO:0005776,GO:0006886,GO:0006914,GO:0031410,GO:0090630,GO:1901096" GTPase activator activity|protein binding|autophagosome|intracellular protein transport|autophagy|cytoplasmic vesicle|activation of GTPase activity|regulation of autophagosome maturation TBC1D2B 1670.042074 1805.118086 1534.966062 0.850341079 -0.23388646 0.32515548 1 15.42854494 12.89998806 23102 TBC1 domain family member 2B "GO:0005096,GO:0005515,GO:0005829,GO:0006886,GO:0090630,GO:1902017" GTPase activator activity|protein binding|cytosol|intracellular protein transport|activation of GTPase activity|regulation of cilium assembly TBC1D3 5.04355356 6.242483296 3.844623824 0.615880514 -0.699277611 0.760739355 1 0.160399548 0.09713389 729873 TBC1 domain family member 3 "GO:0005096,GO:0005886,GO:0006886,GO:0031901,GO:0090630,GO:1902017" GTPase activator activity|plasma membrane|intracellular protein transport|early endosome membrane|activation of GTPase activity|regulation of cilium assembly TBC1D30 25.30205614 20.80827765 29.79583464 1.431922196 0.517953106 0.526521888 1 0.122951676 0.173111154 23329 TBC1 domain family member 30 "GO:0005096,GO:0005829,GO:0005886,GO:0005929,GO:0006886,GO:0031267,GO:0036064,GO:0043547,GO:0090630,GO:1902018" GTPase activator activity|cytosol|plasma membrane|cilium|intracellular protein transport|small GTPase binding|ciliary basal body|positive regulation of GTPase activity|activation of GTPase activity|negative regulation of cilium assembly TBC1D31 977.3900838 1057.060505 897.7196629 0.849260434 -0.235721057 0.339144361 1 13.16531537 10.9936862 93594 TBC1 domain family member 31 GO:0005813 centrosome TBC1D32 88.3118771 85.31393838 91.30981582 1.070280162 0.097988494 0.863389777 1 0.388983177 0.40935441 221322 TBC1 domain family member 32 "GO:0001822,GO:0002088,GO:0003406,GO:0005515,GO:0005737,GO:0005929,GO:0007368,GO:0007507,GO:0042733,GO:0060021,GO:0060831,GO:0061512,GO:1905515" kidney development|lens development in camera-type eye|retinal pigment epithelium development|protein binding|cytoplasm|cilium|determination of left/right symmetry|heart development|embryonic digit morphogenesis|roof of mouth development|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|protein localization to cilium|non-motile cilium assembly TBC1D3C 12.20756385 17.687036 6.728091692 0.380396788 -1.394423029 0.191425962 1 0.256153217 0.095809337 414060 TBC1 domain family member 3C "GO:0005096,GO:0005886,GO:0006886,GO:0090630" GTPase activator activity|plasma membrane|intracellular protein transport|activation of GTPase activity TBC1D3E 4.562975582 6.242483296 2.883467868 0.461910386 -1.11431511 0.584550016 1 0.130035074 0.059059452 102723859 TBC1 domain family member 3E "GO:0005096,GO:0005886,GO:0006886,GO:0090630" GTPase activator activity|plasma membrane|intracellular protein transport|activation of GTPase activity TBC1D3F 9.086322201 11.44455271 6.728091692 0.587885946 -0.766391806 0.566347083 1 0.294065837 0.169984307 84218 TBC1 domain family member 3F "GO:0005096,GO:0005515,GO:0005886,GO:0006886,GO:0090630" GTPase activator activity|protein binding|plasma membrane|intracellular protein transport|activation of GTPase activity TBC1D3G 10.44879821 9.363724944 11.53387147 1.231761029 0.300722389 0.870906207 1 0.128463956 0.155589015 101060321 TBC1 domain family member 3G "GO:0005096,GO:0005515,GO:0005886,GO:0006886,GO:0090630" GTPase activator activity|protein binding|plasma membrane|intracellular protein transport|activation of GTPase activity TBC1D3I 15.53198073 16.64662212 14.41733934 0.866081974 -0.207424514 0.893114177 1 0.230813101 0.196557959 102724862 TBC1 domain family member 3I "GO:0005096,GO:0005886,GO:0006886,GO:0090630" GTPase activator activity|plasma membrane|intracellular protein transport|activation of GTPase activity TBC1D4 784.8135216 820.8865534 748.7404897 0.912112017 -0.132717082 0.601411622 1 3.810821732 3.417731878 9882 TBC1 domain family member 4 "GO:0005096,GO:0005515,GO:0005829,GO:0006886,GO:0016192,GO:0031339,GO:0031982,GO:0032869,GO:0090630" GTPase activator activity|protein binding|cytosol|intracellular protein transport|vesicle-mediated transport|negative regulation of vesicle fusion|vesicle|cellular response to insulin stimulus|activation of GTPase activity "hsa04919,hsa04931" Thyroid hormone signaling pathway|Insulin resistance TBC1D5 1947.677137 1851.936711 2043.417562 1.103394922 0.141949246 0.549581417 1 10.62393406 11.52623649 9779 TBC1 domain family member 5 "GO:0002092,GO:0005096,GO:0005515,GO:0005776,GO:0005794,GO:0005829,GO:0006886,GO:0006914,GO:0010008,GO:0016236,GO:0030122,GO:0030904,GO:0035612,GO:0042147,GO:0042594,GO:0043231,GO:0044877,GO:0090630,GO:1902017,GO:1905394,GO:1990316" "positive regulation of receptor internalization|GTPase activator activity|protein binding|autophagosome|Golgi apparatus|cytosol|intracellular protein transport|autophagy|endosome membrane|macroautophagy|AP-2 adaptor complex|retromer complex|AP-2 adaptor complex binding|retrograde transport, endosome to Golgi|response to starvation|intracellular membrane-bounded organelle|protein-containing complex binding|activation of GTPase activity|regulation of cilium assembly|retromer complex binding|Atg1/ULK1 kinase complex" TBC1D7 5.885822626 3.121241648 8.650403604 2.771462315 1.470647391 0.36367629 1 0.047921441 0.130590032 51256 TBC1 domain family member 7 "GO:0005096,GO:0005515,GO:0005829,GO:0031267,GO:0031398,GO:0031410,GO:0032007,GO:0036064,GO:0043547,GO:0070848,GO:0090630,GO:1902018" GTPase activator activity|protein binding|cytosol|small GTPase binding|positive regulation of protein ubiquitination|cytoplasmic vesicle|negative regulation of TOR signaling|ciliary basal body|positive regulation of GTPase activity|response to growth factor|activation of GTPase activity|negative regulation of cilium assembly hsa04150 mTOR signaling pathway TBC1D7-LOC100130357 5.405244648 3.121241648 7.689247648 2.463522058 1.300722389 0.455625732 1 0.072079156 0.174597222 107080638 TBC1D7-LOC100130357 readthrough "GO:0005096,GO:0005515,GO:0005829,GO:0031267,GO:0031398,GO:0031410,GO:0032007,GO:0036064,GO:0043547,GO:0070848,GO:0090630,GO:1902018" GTPase activator activity|protein binding|cytosol|small GTPase binding|positive regulation of protein ubiquitination|cytoplasmic vesicle|negative regulation of TOR signaling|ciliary basal body|positive regulation of GTPase activity|response to growth factor|activation of GTPase activity|negative regulation of cilium assembly hsa04150 mTOR signaling pathway TBC1D8 1300.103284 1442.013641 1158.192927 0.803177511 -0.316209221 0.188846189 1 12.30140948 9.714883423 11138 TBC1 domain family member 8 "GO:0005096,GO:0005515,GO:0006886,GO:0008015,GO:0008284,GO:0016020,GO:0090630,GO:1902017" GTPase activator activity|protein binding|intracellular protein transport|blood circulation|positive regulation of cell population proliferation|membrane|activation of GTPase activity|regulation of cilium assembly TBC1D8B 449.595233 460.90335 438.2871159 0.950930636 -0.072587984 0.802619521 1 3.89325177 3.640260873 54885 TBC1 domain family member 8B "GO:0003094,GO:0005096,GO:0005509,GO:0005515,GO:0005829,GO:0006886,GO:0016192,GO:0090630" glomerular filtration|GTPase activator activity|calcium ion binding|protein binding|cytosol|intracellular protein transport|vesicle-mediated transport|activation of GTPase activity TBC1D9 1563.013422 1556.459168 1569.567676 1.008422006 0.012099506 0.962440521 1 14.9559534 14.82953714 23158 TBC1 domain family member 9 "GO:0005096,GO:0005509,GO:0005515,GO:0006886,GO:0090630" GTPase activator activity|calcium ion binding|protein binding|intracellular protein transport|activation of GTPase activity TBC1D9B 2351.170868 2427.285588 2275.056148 0.937284083 -0.093441711 0.693681711 1 24.88278346 22.93197084 23061 TBC1 domain family member 9B "GO:0005096,GO:0005509,GO:0005515,GO:0006886,GO:0016021,GO:0090630,GO:1902017" GTPase activator activity|calcium ion binding|protein binding|intracellular protein transport|integral component of membrane|activation of GTPase activity|regulation of cilium assembly TBCA 1304.965627 1102.838716 1507.092539 1.366557519 0.450546185 0.061229693 1 24.24072295 32.57201774 6902 tubulin folding cofactor A "GO:0003723,GO:0005515,GO:0005730,GO:0005737,GO:0005829,GO:0005874,GO:0006457,GO:0007021,GO:0007023,GO:0015630,GO:0015631,GO:0048487,GO:0051087" RNA binding|protein binding|nucleolus|cytoplasm|cytosol|microtubule|protein folding|tubulin complex assembly|post-chaperonin tubulin folding pathway|microtubule cytoskeleton|tubulin binding|beta-tubulin binding|chaperone binding TBCB 1009.793212 847.9373144 1171.64911 1.381763829 0.466511052 0.057597158 1 39.48765796 53.64958596 1155 tubulin folding cofactor B "GO:0005515,GO:0005737,GO:0005829,GO:0005874,GO:0007399,GO:0015630,GO:0030154" protein binding|cytoplasm|cytosol|microtubule|nervous system development|microtubule cytoskeleton|cell differentiation TBCC 253.6741321 275.7096789 231.6385854 0.840153985 -0.251274323 0.454702067 1 9.161966893 7.568656376 6903 tubulin folding cofactor C "GO:0000902,GO:0003924,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005874,GO:0006457,GO:0007021,GO:0007023,GO:0015631,GO:0032391,GO:0051087" cell morphogenesis|GTPase activity|protein binding|cytoplasm|cytosol|cytoskeleton|microtubule|protein folding|tubulin complex assembly|post-chaperonin tubulin folding pathway|tubulin binding|photoreceptor connecting cilium|chaperone binding TBCCD1 225.4540096 241.3760208 209.5319984 0.868072967 -0.20411178 0.563161473 1 4.4236932 3.775829799 55171 TBCC domain containing 1 "GO:0000902,GO:0005515,GO:0005737,GO:0008360,GO:0030334,GO:0031616,GO:0051661,GO:0051684" cell morphogenesis|protein binding|cytoplasm|regulation of cell shape|regulation of cell migration|spindle pole centrosome|maintenance of centrosome location|maintenance of Golgi location TBCD 1864.652232 1665.702626 2063.601838 1.2388777 0.309033773 0.19215262 1 7.448926406 9.073885559 6904 tubulin folding cofactor D "GO:0000226,GO:0000278,GO:0005096,GO:0005515,GO:0005737,GO:0005813,GO:0005874,GO:0005912,GO:0005923,GO:0006457,GO:0007021,GO:0007023,GO:0010812,GO:0016328,GO:0031115,GO:0034333,GO:0043547,GO:0048487,GO:0048667,GO:0051087,GO:0070830" microtubule cytoskeleton organization|mitotic cell cycle|GTPase activator activity|protein binding|cytoplasm|centrosome|microtubule|adherens junction|bicellular tight junction|protein folding|tubulin complex assembly|post-chaperonin tubulin folding pathway|negative regulation of cell-substrate adhesion|lateral plasma membrane|negative regulation of microtubule polymerization|adherens junction assembly|positive regulation of GTPase activity|beta-tubulin binding|cell morphogenesis involved in neuron differentiation|chaperone binding|bicellular tight junction assembly TBCE 430.0204836 439.0546585 420.9863087 0.958847152 -0.060627239 0.838301965 1 4.196944326 3.956888106 6905 tubulin folding cofactor E "GO:0000226,GO:0005515,GO:0005737,GO:0005874,GO:0006457,GO:0007021,GO:0007023,GO:0007052,GO:0043014,GO:0051087" microtubule cytoskeleton organization|protein binding|cytoplasm|microtubule|protein folding|tubulin complex assembly|post-chaperonin tubulin folding pathway|mitotic spindle organization|alpha-tubulin binding|chaperone binding TBCEL 324.1800864 322.5283036 325.8318691 1.010242715 0.014701948 0.973089585 1 3.353349461 3.331008344 219899 tubulin folding cofactor E like "GO:0000226,GO:0005515,GO:0005737,GO:0005856,GO:0007021,GO:0007023,GO:0043014" microtubule cytoskeleton organization|protein binding|cytoplasm|cytoskeleton|tubulin complex assembly|post-chaperonin tubulin folding pathway|alpha-tubulin binding TBCK 158.7681415 156.0620824 161.4742006 1.034679264 0.049183622 0.917982671 1 0.913139624 0.928996575 93627 TBC1 domain containing kinase "GO:0004672,GO:0005096,GO:0005524,GO:0005737,GO:0006468,GO:0006886,GO:0008283,GO:0030036,GO:0030496,GO:0032006,GO:0072686,GO:0090630" protein kinase activity|GTPase activator activity|ATP binding|cytoplasm|protein phosphorylation|intracellular protein transport|cell population proliferation|actin cytoskeleton organization|midbody|regulation of TOR signaling|mitotic spindle|activation of GTPase activity TBK1 1252.502141 1302.598181 1202.406101 0.923082896 -0.115467883 0.634129909 1 20.35048912 18.47084374 29110 TANK binding kinase 1 "GO:0002218,GO:0003676,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006954,GO:0007249,GO:0009615,GO:0010008,GO:0016032,GO:0016239,GO:0018105,GO:0018107,GO:0019903,GO:0032479,GO:0032480,GO:0032481,GO:0032606,GO:0032727,GO:0032728,GO:0033138,GO:0035666,GO:0042802,GO:0043123,GO:0043231,GO:0044565,GO:0045087,GO:0045944,GO:0050830,GO:0051219,GO:0051607,GO:0060340,GO:0071345,GO:0106310,GO:0106311,GO:1901214,GO:1904417" activation of innate immune response|nucleic acid binding|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|inflammatory response|I-kappaB kinase/NF-kappaB signaling|response to virus|endosome membrane|viral process|positive regulation of macroautophagy|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein phosphatase binding|regulation of type I interferon production|negative regulation of type I interferon production|positive regulation of type I interferon production|type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of peptidyl-serine phosphorylation|TRIF-dependent toll-like receptor signaling pathway|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|dendritic cell proliferation|innate immune response|positive regulation of transcription by RNA polymerase II|defense response to Gram-positive bacterium|phosphoprotein binding|defense response to virus|positive regulation of type I interferon-mediated signaling pathway|cellular response to cytokine stimulus|protein serine kinase activity|protein threonine kinase activity|regulation of neuron death|positive regulation of xenophagy "hsa04014,hsa04137,hsa04140,hsa04620,hsa04621,hsa04622,hsa04623,hsa04657,hsa05014,hsa05022,hsa05131,hsa05135,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05171" Ras signaling pathway|Mitophagy - animal|Autophagy - animal|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|IL-17 signaling pathway|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Shigellosis|Yersinia infection|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19 TBKBP1 309.0840242 317.3262342 300.8418142 0.948052136 -0.076961695 0.81418033 1 3.261143443 3.039998026 9755 TBK1 binding protein 1 "GO:0005515,GO:0005737,GO:0007249,GO:0016032,GO:0045087,GO:0046872" protein binding|cytoplasm|I-kappaB kinase/NF-kappaB signaling|viral process|innate immune response|metal ion binding hsa04622 RIG-I-like receptor signaling pathway TBL1X 1339.956658 1428.488261 1251.425055 0.87604854 -0.190917287 0.427339974 1 12.45479383 10.72842307 6907 transducin beta like 1 X-linked "GO:0000118,GO:0000122,GO:0000976,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006508,GO:0007605,GO:0008013,GO:0008022,GO:0008134,GO:0016575,GO:0017053,GO:0019216,GO:0019904,GO:0042393,GO:0043161,GO:0045893,GO:0045944,GO:0050821,GO:0072686,GO:0090263" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|proteolysis|sensory perception of sound|beta-catenin binding|protein C-terminus binding|transcription factor binding|histone deacetylation|transcription repressor complex|regulation of lipid metabolic process|protein domain specific binding|histone binding|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein stabilization|mitotic spindle|positive regulation of canonical Wnt signaling pathway" hsa04310 Wnt signaling pathway other TBL1XR1 1690.689263 1451.377366 1930.00116 1.329772122 0.411179037 0.083527342 1 8.880685912 11.6116761 79718 TBL1X receptor 1 "GO:0000118,GO:0000122,GO:0000976,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008013,GO:0016575,GO:0017053,GO:0019216,GO:0042393,GO:0043161,GO:0045893,GO:0045944,GO:0047485,GO:0072686,GO:0090263" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|beta-catenin binding|histone deacetylation|transcription repressor complex|regulation of lipid metabolic process|histone binding|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein N-terminus binding|mitotic spindle|positive regulation of canonical Wnt signaling pathway" hsa04310 Wnt signaling pathway other TBL2 975.8596455 979.0294636 972.6898275 0.993524571 -0.009372448 0.974292332 1 10.66523843 10.41886377 26608 transducin beta like 2 "GO:0003723,GO:0005783,GO:0019901,GO:0030176,GO:0030968,GO:0031369,GO:0042149,GO:0051219,GO:0071456" RNA binding|endoplasmic reticulum|protein kinase binding|integral component of endoplasmic reticulum membrane|endoplasmic reticulum unfolded protein response|translation initiation factor binding|cellular response to glucose starvation|phosphoprotein binding|cellular response to hypoxia TBL3 607.327991 602.399638 612.256344 1.016362403 0.023414914 0.935588121 1 4.739637553 4.736580273 10607 transducin beta like 3 "GO:0000472,GO:0000480,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0030686,GO:0032040,GO:0034511" "endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|protein binding|nucleoplasm|nucleolus|rRNA processing|90S preribosome|small-subunit processome|U3 snoRNA binding" hsa03008 Ribosome biogenesis in eukaryotes TBP 311.8536356 301.720026 321.9872453 1.067172271 0.093793085 0.771432721 1 8.67110568 9.098717685 6908 TATA-box binding protein "GO:0000785,GO:0000791,GO:0000976,GO:0000978,GO:0000979,GO:0000995,GO:0001046,GO:0001091,GO:0001093,GO:0001103,GO:0001939,GO:0001940,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0005672,GO:0005737,GO:0006352,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006383,GO:0007283,GO:0008134,GO:0016032,GO:0016251,GO:0017162,GO:0019899,GO:0032991,GO:0042795,GO:0045815,GO:0045893,GO:0051123,GO:0070491,GO:0097550,GO:0140223,GO:1901796" "chromatin|euchromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase III general transcription initiation factor activity|core promoter sequence-specific DNA binding|RNA polymerase II general transcription initiation factor binding|TFIIB-class transcription factor binding|RNA polymerase II repressing transcription factor binding|female pronucleus|male pronucleus|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIA complex|cytoplasm|DNA-templated transcription, initiation|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|transcription by RNA polymerase III|spermatogenesis|transcription factor binding|viral process|RNA polymerase II general transcription initiation factor activity|aryl hydrocarbon receptor binding|enzyme binding|protein-containing complex|snRNA transcription by RNA polymerase II|positive regulation of gene expression, epigenetic|positive regulation of transcription, DNA-templated|RNA polymerase II preinitiation complex assembly|repressing transcription factor binding|transcription preinitiation complex|general transcription initiation factor activity|regulation of signal transduction by p53 class mediator" "hsa03022,hsa05016,hsa05017,hsa05165,hsa05166,hsa05203" Basal transcription factors|Huntington disease|Spinocerebellar ataxia|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis other TBPL1 471.0381884 418.2463808 523.829996 1.252443584 0.324745619 0.242033197 1 4.557174488 5.612094924 9519 TATA-box binding protein like 1 "GO:0000979,GO:0001675,GO:0005515,GO:0005672,GO:0005737,GO:0006235,GO:0006352,GO:0006366,GO:0007289,GO:0016251,GO:0140223" "RNA polymerase II core promoter sequence-specific DNA binding|acrosome assembly|protein binding|transcription factor TFIIA complex|cytoplasm|dTTP biosynthetic process|DNA-templated transcription, initiation|transcription by RNA polymerase II|spermatid nucleus differentiation|RNA polymerase II general transcription initiation factor activity|general transcription initiation factor activity" "hsa03022,hsa05016,hsa05017,hsa05165,hsa05166,hsa05203" Basal transcription factors|Huntington disease|Spinocerebellar ataxia|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis TBRG1 1330.454539 1355.659289 1305.249788 0.962815509 -0.054668714 0.822739451 1 9.610659493 9.0984507 84897 transforming growth factor beta regulator 1 "GO:0005515,GO:0005634,GO:0005654,GO:0006260,GO:0007050,GO:0008285,GO:0050821,GO:1990173" protein binding|nucleus|nucleoplasm|DNA replication|cell cycle arrest|negative regulation of cell population proliferation|protein stabilization|protein localization to nucleoplasm TBRG4 1398.533065 1363.9826 1433.08353 1.050661152 0.071297462 0.768311481 1 32.70136769 33.78312111 9238 transforming growth factor beta regulator 4 "GO:0003723,GO:0005515,GO:0005739,GO:0005759,GO:0007050,GO:0008284,GO:0016071,GO:0044528,GO:0090615" RNA binding|protein binding|mitochondrion|mitochondrial matrix|cell cycle arrest|positive regulation of cell population proliferation|mRNA metabolic process|regulation of mitochondrial mRNA stability|mitochondrial mRNA processing TBX1 2.442518853 1.040413883 3.844623824 3.695283087 1.88568489 0.568729642 1 0.010800423 0.039242772 6899 T-box transcription factor 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001525,GO:0001568,GO:0001708,GO:0001755,GO:0001934,GO:0001945,GO:0002053,GO:0003007,GO:0003148,GO:0003151,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0007368,GO:0007389,GO:0007498,GO:0007507,GO:0007517,GO:0007605,GO:0008283,GO:0008284,GO:0009952,GO:0021644,GO:0030855,GO:0030878,GO:0035176,GO:0035909,GO:0042471,GO:0042472,GO:0042473,GO:0042474,GO:0042475,GO:0042693,GO:0042803,GO:0043410,GO:0043565,GO:0043587,GO:0044344,GO:0045596,GO:0045893,GO:0045944,GO:0048384,GO:0048514,GO:0048538,GO:0048644,GO:0048701,GO:0048703,GO:0048752,GO:0048844,GO:0050679,GO:0060017,GO:0060023,GO:0060037,GO:0060325,GO:0060415,GO:0060982,GO:0070166,GO:0071300,GO:0090103,GO:0097152,GO:1990837,GO:2000027,GO:2001037,GO:2001054" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|angiogenesis|blood vessel development|cell fate specification|neural crest cell migration|positive regulation of protein phosphorylation|lymph vessel development|positive regulation of mesenchymal cell proliferation|heart morphogenesis|outflow tract septum morphogenesis|outflow tract morphogenesis|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|determination of left/right symmetry|pattern specification process|mesoderm development|heart development|muscle organ development|sensory perception of sound|cell population proliferation|positive regulation of cell population proliferation|anterior/posterior pattern specification|vagus nerve morphogenesis|epithelial cell differentiation|thyroid gland development|social behavior|aorta morphogenesis|ear morphogenesis|inner ear morphogenesis|outer ear morphogenesis|middle ear morphogenesis|odontogenesis of dentin-containing tooth|muscle cell fate commitment|protein homodimerization activity|positive regulation of MAPK cascade|sequence-specific DNA binding|tongue morphogenesis|cellular response to fibroblast growth factor stimulus|negative regulation of cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|retinoic acid receptor signaling pathway|blood vessel morphogenesis|thymus development|muscle organ morphogenesis|embryonic cranial skeleton morphogenesis|embryonic viscerocranium morphogenesis|semicircular canal morphogenesis|artery morphogenesis|positive regulation of epithelial cell proliferation|parathyroid gland development|soft palate development|pharyngeal system development|face morphogenesis|muscle tissue morphogenesis|coronary artery morphogenesis|enamel mineralization|cellular response to retinoic acid|cochlea morphogenesis|mesenchymal cell apoptotic process|sequence-specific double-stranded DNA binding|regulation of animal organ morphogenesis|positive regulation of tongue muscle cell differentiation|negative regulation of mesenchymal cell apoptotic process" TBX15 2.883467868 0 5.766935736 Inf Inf 0.126446699 1 0 0.066393294 6913 T-box transcription factor 15 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001708,GO:0005515,GO:0006357,GO:0042803,GO:0048701,GO:0090571,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|cell fate specification|protein binding|regulation of transcription by RNA polymerase II|protein homodimerization activity|embryonic cranial skeleton morphogenesis|RNA polymerase II transcription repressor complex|sequence-specific double-stranded DNA binding" TBX19 46.35816841 43.69738307 49.01895376 1.121782366 0.165792809 0.819093195 1 0.781255954 0.861733799 9095 T-box transcription factor 19 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001707,GO:0001708,GO:0001756,GO:0003007,GO:0005515,GO:0005634,GO:0006357,GO:0009653,GO:0021983,GO:0042127,GO:0045595,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|mesoderm formation|cell fate specification|somitogenesis|heart morphogenesis|protein binding|nucleus|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|pituitary gland development|regulation of cell population proliferation|regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" TBX2 240.9564222 232.0122958 249.9005486 1.077100451 0.107152803 0.762120388 1 3.606778272 3.819854592 6909 T-box transcription factor 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001708,GO:0001947,GO:0003148,GO:0003151,GO:0003203,GO:0003256,GO:0003677,GO:0005515,GO:0005634,GO:0005667,GO:0006357,GO:0007219,GO:0007521,GO:0007569,GO:0008016,GO:0008284,GO:0035050,GO:0035909,GO:0036302,GO:0042733,GO:0043565,GO:0045892,GO:0048596,GO:0048738,GO:0051145,GO:0060021,GO:0060045,GO:0060465,GO:0060560,GO:0060596,GO:0072105,GO:0090398,GO:1901208,GO:1901211,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|cell fate specification|heart looping|outflow tract septum morphogenesis|outflow tract morphogenesis|endocardial cushion morphogenesis|regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|DNA binding|protein binding|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|Notch signaling pathway|muscle cell fate determination|cell aging|regulation of heart contraction|positive regulation of cell population proliferation|embryonic heart tube development|aorta morphogenesis|atrioventricular canal development|embryonic digit morphogenesis|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|embryonic camera-type eye morphogenesis|cardiac muscle tissue development|smooth muscle cell differentiation|roof of mouth development|positive regulation of cardiac muscle cell proliferation|pharynx development|developmental growth involved in morphogenesis|mammary placode formation|ureteric peristalsis|cellular senescence|negative regulation of heart looping|negative regulation of cardiac chamber formation|sequence-specific double-stranded DNA binding" TBX20 94.15807076 87.39476614 100.9213754 1.154775965 0.207612985 0.679005766 1 0.647971387 0.735740636 57057 T-box transcription factor 20 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001085,GO:0001102,GO:0001228,GO:0001569,GO:0001570,GO:0001706,GO:0001708,GO:0001764,GO:0001947,GO:0003143,GO:0003148,GO:0003175,GO:0003180,GO:0003193,GO:0003203,GO:0003207,GO:0003215,GO:0003272,GO:0003279,GO:0003344,GO:0005634,GO:0005737,GO:0006357,GO:0006936,GO:0008015,GO:0008283,GO:0009953,GO:0010991,GO:0021524,GO:0035922,GO:0036306,GO:0045892,GO:0045944,GO:0048370,GO:0055008,GO:0060045,GO:0060413,GO:0060577,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|branching involved in blood vessel morphogenesis|vasculogenesis|endoderm formation|cell fate specification|neuron migration|heart looping|embryonic heart tube morphogenesis|outflow tract septum morphogenesis|tricuspid valve development|aortic valve morphogenesis|pulmonary valve formation|endocardial cushion morphogenesis|cardiac chamber formation|cardiac right ventricle morphogenesis|endocardial cushion formation|cardiac septum development|pericardium morphogenesis|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|muscle contraction|blood circulation|cell population proliferation|dorsal/ventral pattern formation|negative regulation of SMAD protein complex assembly|visceral motor neuron differentiation|foramen ovale closure|embryonic heart tube elongation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|lateral mesoderm formation|cardiac muscle tissue morphogenesis|positive regulation of cardiac muscle cell proliferation|atrial septum morphogenesis|pulmonary vein morphogenesis|sequence-specific double-stranded DNA binding" TBX22 7.248298633 1.040413883 13.45618338 12.9334908 3.693039812 0.025945894 0.86539048 0.022700318 0.288681444 50945 T-box transcription factor 22 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001708,GO:0001947,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0007275,GO:0045892" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cell fate specification|heart looping|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|negative regulation of transcription, DNA-templated" TBX3 254.754175 278.8309205 230.6774294 0.827302184 -0.273513705 0.414279654 1 3.10467218 2.525521671 6926 T-box transcription factor 3 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001085,GO:0001102,GO:0001227,GO:0001501,GO:0001568,GO:0001701,GO:0001708,GO:0001947,GO:0003151,GO:0003167,GO:0003205,GO:0005515,GO:0005634,GO:0006357,GO:0007417,GO:0007569,GO:0008284,GO:0008595,GO:0009887,GO:0010159,GO:0019827,GO:0021761,GO:0030539,GO:0030540,GO:0030857,GO:0030879,GO:0032275,GO:0035115,GO:0035116,GO:0035136,GO:0042733,GO:0043066,GO:0043565,GO:0045662,GO:0045787,GO:0045892,GO:0045893,GO:0046884,GO:0048332,GO:0051145,GO:0060021,GO:0060412,GO:0060444,GO:0060596,GO:0060923,GO:0060931,GO:0072105,GO:0090398,GO:1990837,GO:2000648" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|skeletal system development|blood vessel development|in utero embryonic development|cell fate specification|heart looping|outflow tract morphogenesis|atrioventricular bundle cell differentiation|cardiac chamber development|protein binding|nucleus|regulation of transcription by RNA polymerase II|central nervous system development|cell aging|positive regulation of cell population proliferation|anterior/posterior axis specification, embryo|animal organ morphogenesis|specification of animal organ position|stem cell population maintenance|limbic system development|male genitalia development|female genitalia development|negative regulation of epithelial cell differentiation|mammary gland development|luteinizing hormone secretion|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|forelimb morphogenesis|embryonic digit morphogenesis|negative regulation of apoptotic process|sequence-specific DNA binding|negative regulation of myoblast differentiation|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|follicle-stimulating hormone secretion|mesoderm morphogenesis|smooth muscle cell differentiation|roof of mouth development|ventricular septum morphogenesis|branching involved in mammary gland duct morphogenesis|mammary placode formation|cardiac muscle cell fate commitment|sinoatrial node cell development|ureteric peristalsis|cellular senescence|sequence-specific double-stranded DNA binding|positive regulation of stem cell proliferation" hsa04550 Signaling pathways regulating pluripotency of stem cells T-box TBX6 35.58730808 38.49531366 32.6793025 0.848916385 -0.236305634 0.760493828 1 0.909439636 0.759119194 6911 T-box transcription factor 6 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001085,GO:0001102,GO:0001707,GO:0001708,GO:0001947,GO:0003205,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0007417,GO:0007498,GO:0008284,GO:0009653,GO:0010977,GO:0014043,GO:0023019,GO:0032525,GO:0043433,GO:0045944,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|mesoderm formation|cell fate specification|heart looping|cardiac chamber development|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|central nervous system development|mesoderm development|positive regulation of cell population proliferation|anatomical structure morphogenesis|negative regulation of neuron projection development|negative regulation of neuron maturation|signal transduction involved in regulation of gene expression|somite rostral/caudal axis specification|negative regulation of DNA-binding transcription factor activity|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" TBXA2R 44.55474339 46.81862472 42.29086206 0.903291421 -0.146736588 0.847554402 1 0.539193775 0.478899004 6915 thromboxane A2 receptor "GO:0001669,GO:0004961,GO:0005085,GO:0005515,GO:0005886,GO:0005887,GO:0006954,GO:0007186,GO:0007189,GO:0007204,GO:0007584,GO:0016607,GO:0030194,GO:0033574,GO:0038193,GO:0042493,GO:0045471,GO:0045766,GO:0045777,GO:0045907,GO:0045987,GO:0050790,GO:0071222,GO:0090051" acrosomal vesicle|thromboxane A2 receptor activity|guanyl-nucleotide exchange factor activity|protein binding|plasma membrane|integral component of plasma membrane|inflammatory response|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|response to nutrient|nuclear speck|positive regulation of blood coagulation|response to testosterone|thromboxane A2 signaling pathway|response to drug|response to ethanol|positive regulation of angiogenesis|positive regulation of blood pressure|positive regulation of vasoconstriction|positive regulation of smooth muscle contraction|regulation of catalytic activity|cellular response to lipopolysaccharide|negative regulation of cell migration involved in sprouting angiogenesis "hsa04020,hsa04080,hsa04611" Calcium signaling pathway|Neuroactive ligand-receptor interaction|Platelet activation TBXAS1 47.67598504 53.06110801 42.29086206 0.797021842 -0.327308833 0.610188123 1 0.320010601 0.250787432 6916 thromboxane A synthase 1 "GO:0001516,GO:0004497,GO:0004796,GO:0005506,GO:0005789,GO:0006690,GO:0016021,GO:0016705,GO:0019371,GO:0020037,GO:0036134,GO:0055114,GO:0106256" "prostaglandin biosynthetic process|monooxygenase activity|thromboxane-A synthase activity|iron ion binding|endoplasmic reticulum membrane|icosanoid metabolic process|integral component of membrane|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|cyclooxygenase pathway|heme binding|12-hydroxyheptadecatrienoic acid synthase activity|oxidation-reduction process|hydroperoxy icosatetraenoate dehydratase activity" "hsa00590,hsa04611" Arachidonic acid metabolism|Platelet activation TC2N 38.3122601 34.33365813 42.29086206 1.231761029 0.300722389 0.675647955 1 0.337382477 0.408620509 123036 "tandem C2 domains, nuclear" "GO:0003674,GO:0005575,GO:0005634" molecular_function|cellular_component|nucleus TCAF1 1302.432561 1326.5277 1278.337421 0.963671864 -0.053386111 0.827224485 1 11.29276524 10.70041589 9747 TRPM8 channel associated factor 1 "GO:0005515,GO:0005886,GO:0010359,GO:0030336,GO:0044325,GO:0090314,GO:1901529" protein binding|plasma membrane|regulation of anion channel activity|negative regulation of cell migration|ion channel binding|positive regulation of protein targeting to membrane|positive regulation of anion channel activity TCAF2 88.38610461 99.87973273 76.89247648 0.769850643 -0.377349516 0.446883565 1 0.591346546 0.447630551 285966 TRPM8 channel associated factor 2 "GO:0005886,GO:0010359,GO:0010360,GO:0030054,GO:0030335,GO:0044325,GO:0090314" plasma membrane|regulation of anion channel activity|negative regulation of anion channel activity|cell junction|positive regulation of cell migration|ion channel binding|positive regulation of protein targeting to membrane TCAIM 593.7327991 649.2182628 538.2473354 0.829069923 -0.270434312 0.305401656 1 6.734224581 5.48971672 285343 "T cell activation inhibitor, mitochondrial" GO:0005739 mitochondrion TCAP 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.173515552 0.262691523 8557 titin-cap "GO:0001756,GO:0003009,GO:0003300,GO:0005515,GO:0005829,GO:0007512,GO:0008307,GO:0014898,GO:0030018,GO:0030049,GO:0030240,GO:0030241,GO:0030674,GO:0030916,GO:0031432,GO:0031674,GO:0035994,GO:0035995,GO:0036122,GO:0044325,GO:0045214,GO:0048739,GO:0048769,GO:0050982,GO:0051373,GO:0055003,GO:0055008,GO:0060048,GO:0065003,GO:0070080" somitogenesis|skeletal muscle contraction|cardiac muscle hypertrophy|protein binding|cytosol|adult heart development|structural constituent of muscle|cardiac muscle hypertrophy in response to stress|Z disc|muscle filament sliding|skeletal muscle thin filament assembly|skeletal muscle myosin thick filament assembly|protein-macromolecule adaptor activity|otic vesicle formation|titin binding|I band|response to muscle stretch|detection of muscle stretch|BMP binding|ion channel binding|sarcomere organization|cardiac muscle fiber development|sarcomerogenesis|detection of mechanical stimulus|FATZ binding|cardiac myofibril assembly|cardiac muscle tissue morphogenesis|cardiac muscle contraction|protein-containing complex assembly|titin Z domain binding TCEA1 5838.394937 6228.957915 5447.831959 0.874597651 -0.193308622 0.424126731 1 110.3312431 94.88072544 6917 transcription elongation factor A1 "GO:0003677,GO:0005515,GO:0005654,GO:0005669,GO:0005730,GO:0006283,GO:0006366,GO:0006368,GO:0008270,GO:0045944,GO:1901919" DNA binding|protein binding|nucleoplasm|transcription factor TFIID complex|nucleolus|transcription-coupled nucleotide-excision repair|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|zinc ion binding|positive regulation of transcription by RNA polymerase II|positive regulation of exoribonuclease activity TCEA2 418.5268555 339.1749257 497.8787852 1.467911533 0.553765024 0.052636192 1 3.523679659 5.085896064 6919 transcription elongation factor A2 "GO:0003677,GO:0005515,GO:0005654,GO:0005813,GO:0006354,GO:0008023,GO:0008270,GO:0032784,GO:0045944" "DNA binding|protein binding|nucleoplasm|centrosome|DNA-templated transcription, elongation|transcription elongation factor complex|zinc ion binding|regulation of DNA-templated transcription, elongation|positive regulation of transcription by RNA polymerase II" TCEA3 320.6776463 268.4267817 372.9285109 1.389311858 0.474370477 0.123956387 1 6.011516573 8.212114006 6920 transcription elongation factor A3 "GO:0003677,GO:0005515,GO:0005634,GO:0006351,GO:0006355,GO:0008270" "DNA binding|protein binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding" TCEAL1 588.6502309 541.015219 636.2852429 1.176094906 0.234004484 0.37673549 1 22.80646753 26.37373089 9338 transcription elongation factor A like 1 "GO:0005634,GO:0005654,GO:0010629,GO:0050699" nucleus|nucleoplasm|negative regulation of gene expression|WW domain binding TCEAL3 1163.829802 1018.565191 1309.094412 1.285233801 0.362030828 0.135848471 1 51.4762805 65.05197344 85012 transcription elongation factor A like 3 "GO:0005634,GO:0050699" nucleus|WW domain binding TCEAL4 1828.56361 1778.067325 1879.059894 1.056799069 0.079701101 0.73830746 1 43.4886275 45.18968376 79921 transcription elongation factor A like 4 "GO:0005515,GO:0005634,GO:0050699" protein binding|nucleus|WW domain binding TCEAL8 1612.023544 1379.588808 1844.45828 1.336962339 0.418958826 0.078346334 1 62.71390045 82.44307169 90843 transcription elongation factor A like 8 "GO:0005515,GO:0005634,GO:0050699" protein binding|nucleus|WW domain binding TCEAL9 1586.666768 1395.195017 1778.138519 1.2744731 0.349900924 0.141674037 1 72.4309278 90.76656505 51186 transcription elongation factor A like 9 "GO:0005634,GO:0050699" nucleus|WW domain binding TCEANC 26.09966583 29.13158871 23.06774294 0.791846376 -0.336707531 0.693708007 1 0.456057304 0.355084346 170082 transcription elongation factor A N-terminal and central domain containing "GO:0005515,GO:0005634,GO:0006351" "protein binding|nucleus|transcription, DNA-templated" TCEANC2 440.6774875 428.6505196 452.7044553 1.056115494 0.078767613 0.786746522 1 2.193526743 2.277852122 127428 transcription elongation factor A N-terminal and central domain containing 2 "GO:0005515,GO:0005634,GO:0006351" "protein binding|nucleus|transcription, DNA-templated" TCERG1 1819.036338 1767.663187 1870.40949 1.058125498 0.081510748 0.732574964 1 17.35730183 18.0588701 10915 transcription elongation regulator 1 "GO:0000122,GO:0001103,GO:0003711,GO:0003712,GO:0003713,GO:0003714,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006397,GO:0008380,GO:0016607,GO:0032968,GO:0034244,GO:0042802,GO:0044390,GO:0045944,GO:0070063" negative regulation of transcription by RNA polymerase II|RNA polymerase II repressing transcription factor binding|transcription elongation regulator activity|transcription coregulator activity|transcription coactivator activity|transcription corepressor activity|RNA binding|protein binding|nucleus|nucleoplasm|mRNA processing|RNA splicing|nuclear speck|positive regulation of transcription elongation from RNA polymerase II promoter|negative regulation of transcription elongation from RNA polymerase II promoter|identical protein binding|ubiquitin-like protein conjugating enzyme binding|positive regulation of transcription by RNA polymerase II|RNA polymerase binding hsa03040 Spliceosome TCF12 1599.700281 1649.056004 1550.344557 0.940140634 -0.089051512 0.709999141 1 10.41134368 9.624336191 6938 transcription factor 12 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0000987,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006357,GO:0006955,GO:0007399,GO:0007517,GO:0008134,GO:0016607,GO:0030154,GO:0035497,GO:0043231,GO:0043425,GO:0045666,GO:0045944,GO:0046332,GO:0046982,GO:0070888,GO:0071837,GO:0090575,GO:1902036,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|regulation of transcription by RNA polymerase II|immune response|nervous system development|muscle organ development|transcription factor binding|nuclear speck|cell differentiation|cAMP response element binding|intracellular membrane-bounded organelle|bHLH transcription factor binding|positive regulation of neuron differentiation|positive regulation of transcription by RNA polymerase II|SMAD binding|protein heterodimerization activity|E-box binding|HMG box domain binding|RNA polymerase II transcription regulator complex|regulation of hematopoietic stem cell differentiation|sequence-specific double-stranded DNA binding" bHLH TCF19 1523.344331 1410.801225 1635.887437 1.159544951 0.213558749 0.370969824 1 24.00888662 27.37352888 6941 transcription factor 19 "GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0010468,GO:0046872" "DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of gene expression|metal ion binding" TCF20 1683.563038 1743.733667 1623.39241 0.930986446 -0.103167931 0.665518244 1 10.37919484 9.501194347 6942 transcription factor 20 "GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0016604,GO:0045944,GO:0046872" DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|nuclear body|positive regulation of transcription by RNA polymerase II|metal ion binding TCF21 12.049048 13.52538047 10.57271552 0.781694499 -0.355323209 0.80166462 1 0.197058339 0.151461779 6943 transcription factor 21 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0001228,GO:0001657,GO:0001658,GO:0001763,GO:0001822,GO:0001944,GO:0005515,GO:0005634,GO:0006357,GO:0007530,GO:0014707,GO:0030855,GO:0032502,GO:0032835,GO:0042826,GO:0043425,GO:0045944,GO:0046983,GO:0048286,GO:0048536,GO:0048557,GO:0048608,GO:0048732,GO:0050681,GO:0060008,GO:0060021,GO:0060425,GO:0060426,GO:0060435,GO:0060539,GO:0060541,GO:0060766,GO:0070888,GO:0072162,GO:0072277,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|ureteric bud development|branching involved in ureteric bud morphogenesis|morphogenesis of a branching structure|kidney development|vasculature development|protein binding|nucleus|regulation of transcription by RNA polymerase II|sex determination|branchiomeric skeletal muscle development|epithelial cell differentiation|developmental process|glomerulus development|histone deacetylase binding|bHLH transcription factor binding|positive regulation of transcription by RNA polymerase II|protein dimerization activity|lung alveolus development|spleen development|embryonic digestive tract morphogenesis|reproductive structure development|gland development|androgen receptor binding|Sertoli cell differentiation|roof of mouth development|lung morphogenesis|lung vasculature development|bronchiole development|diaphragm development|respiratory system development|negative regulation of androgen receptor signaling pathway|E-box binding|metanephric mesenchymal cell differentiation|metanephric glomerular capillary formation|sequence-specific double-stranded DNA binding" bHLH TCF25 1618.542201 1601.196965 1635.887437 1.021665337 0.030922695 0.899158057 1 26.1323973 26.25180017 22980 transcription factor 25 "GO:0000122,GO:0003677,GO:0003714,GO:0005515,GO:0005634,GO:0007507,GO:1990112" negative regulation of transcription by RNA polymerase II|DNA binding|transcription corepressor activity|protein binding|nucleus|heart development|RQC complex TCF3 1526.13345 1446.175297 1606.091602 1.110578784 0.151311741 0.526761523 1 15.53224344 16.96112832 6929 transcription factor 3 "GO:0000122,GO:0000785,GO:0000791,GO:0000978,GO:0000981,GO:0000987,GO:0001102,GO:0001227,GO:0001228,GO:0002326,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006355,GO:0006357,GO:0007399,GO:0008134,GO:0030183,GO:0031435,GO:0033152,GO:0042803,GO:0043425,GO:0045666,GO:0045893,GO:0045944,GO:0046982,GO:0051091,GO:0051149,GO:0070491,GO:0070644,GO:0070888,GO:0090575,GO:1902036" "negative regulation of transcription by RNA polymerase II|chromatin|euchromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|B cell lineage commitment|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|nervous system development|transcription factor binding|B cell differentiation|mitogen-activated protein kinase kinase kinase binding|immunoglobulin V(D)J recombination|protein homodimerization activity|bHLH transcription factor binding|positive regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|positive regulation of DNA-binding transcription factor activity|positive regulation of muscle cell differentiation|repressing transcription factor binding|vitamin D response element binding|E-box binding|RNA polymerase II transcription regulator complex|regulation of hematopoietic stem cell differentiation" "hsa04550,hsa05166,hsa05202" Signaling pathways regulating pluripotency of stem cells|Human T-cell leukemia virus 1 infection|Transcriptional misregulation in cancer bHLH TCF4 751.5303382 729.3301317 773.7305446 1.060878347 0.085259229 0.740794658 1 3.468146545 3.61771378 6925 transcription factor 4 "GO:0000785,GO:0000978,GO:0000981,GO:0001093,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005667,GO:0006357,GO:0007399,GO:0008013,GO:0008022,GO:0030154,GO:0042802,GO:0045666,GO:0045893,GO:0045944,GO:0046982,GO:0065004,GO:0070369,GO:0070888,GO:1990837,GO:1990907" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|TFIIB-class transcription factor binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|nervous system development|beta-catenin binding|protein C-terminus binding|cell differentiation|identical protein binding|positive regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|protein-DNA complex assembly|beta-catenin-TCF7L2 complex|E-box binding|sequence-specific double-stranded DNA binding|beta-catenin-TCF complex" bHLH TCF7 160.2841029 170.6278768 149.9403291 0.878756344 -0.186464896 0.647106297 1 0.636745415 0.550180861 6932 transcription factor 7 "GO:0000976,GO:0000978,GO:0000981,GO:0001217,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0006955,GO:0008013,GO:0016604,GO:0033153,GO:0042492,GO:0045586,GO:0045892,GO:0060070,GO:0071353,GO:1904837,GO:1990837,GO:1990907" "transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|immune response|beta-catenin binding|nuclear body|T cell receptor V(D)J recombination|gamma-delta T cell differentiation|regulation of gamma-delta T cell differentiation|negative regulation of transcription, DNA-templated|canonical Wnt signaling pathway|cellular response to interleukin-4|beta-catenin-TCF complex assembly|sequence-specific double-stranded DNA binding|beta-catenin-TCF complex" "hsa04310,hsa04390,hsa04520,hsa04550,hsa04916,hsa04934,hsa05132,hsa05165,hsa05167,hsa05200,hsa05210,hsa05213,hsa05215,hsa05216,hsa05217,hsa05221,hsa05224,hsa05225,hsa05226,hsa05412" Wnt signaling pathway|Hippo signaling pathway|Adherens junction|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Salmonella infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy TCF7L1 203.8034629 202.8807071 204.7262186 1.009096535 0.013064197 0.986605936 1 3.623617958 3.595392407 83439 transcription factor 7 like 1 "GO:0000978,GO:0000981,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0006325,GO:0006355,GO:0006357,GO:0008013,GO:0030111,GO:0060070,GO:1904837,GO:1990837,GO:1990907" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytosol|chromatin organization|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|beta-catenin binding|regulation of Wnt signaling pathway|canonical Wnt signaling pathway|beta-catenin-TCF complex assembly|sequence-specific double-stranded DNA binding|beta-catenin-TCF complex" "hsa04310,hsa04390,hsa04520,hsa04916,hsa04934,hsa05132,hsa05165,hsa05167,hsa05200,hsa05210,hsa05213,hsa05215,hsa05216,hsa05217,hsa05221,hsa05224,hsa05225,hsa05226,hsa05412" Wnt signaling pathway|Hippo signaling pathway|Adherens junction|Melanogenesis|Cushing syndrome|Salmonella infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy TCF7L2 231.3398322 244.4972624 218.182402 0.892371554 -0.164283569 0.640877287 1 2.463815999 2.16184806 6934 transcription factor 7 like 2 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001103,GO:0001568,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007050,GO:0007223,GO:0008013,GO:0008134,GO:0009749,GO:0010909,GO:0016605,GO:0019901,GO:0031016,GO:0032024,GO:0032092,GO:0032350,GO:0032993,GO:0035257,GO:0042593,GO:0043433,GO:0043565,GO:0043570,GO:0044334,GO:0045295,GO:0045444,GO:0045892,GO:0045944,GO:0046827,GO:0048625,GO:0048660,GO:0050679,GO:0051897,GO:0060070,GO:0070016,GO:0070369,GO:0071664,GO:0090090,GO:1904837,GO:1990907,GO:2000675,GO:2001237" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II repressing transcription factor binding|blood vessel development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cell cycle arrest|Wnt signaling pathway, calcium modulating pathway|beta-catenin binding|transcription factor binding|response to glucose|positive regulation of heparan sulfate proteoglycan biosynthetic process|PML body|protein kinase binding|pancreas development|positive regulation of insulin secretion|positive regulation of protein binding|regulation of hormone metabolic process|protein-DNA complex|nuclear hormone receptor binding|glucose homeostasis|negative regulation of DNA-binding transcription factor activity|sequence-specific DNA binding|maintenance of DNA repeat elements|canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition|gamma-catenin binding|fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of protein export from nucleus|myoblast fate commitment|regulation of smooth muscle cell proliferation|positive regulation of epithelial cell proliferation|positive regulation of protein kinase B signaling|canonical Wnt signaling pathway|armadillo repeat domain binding|beta-catenin-TCF7L2 complex|catenin-TCF7L2 complex|negative regulation of canonical Wnt signaling pathway|beta-catenin-TCF complex assembly|beta-catenin-TCF complex|negative regulation of type B pancreatic cell apoptotic process|negative regulation of extrinsic apoptotic signaling pathway" "hsa04310,hsa04390,hsa04520,hsa04916,hsa04934,hsa05132,hsa05165,hsa05167,hsa05200,hsa05210,hsa05213,hsa05215,hsa05216,hsa05217,hsa05221,hsa05224,hsa05225,hsa05226,hsa05412" Wnt signaling pathway|Hippo signaling pathway|Adherens junction|Melanogenesis|Cushing syndrome|Salmonella infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy HMG TCFL5 830.0822007 785.5124814 874.65192 1.113479341 0.155074791 0.538042083 1 8.31443027 9.103027142 10732 transcription factor like 5 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001673,GO:0003677,GO:0003700,GO:0005634,GO:0006355,GO:0006366,GO:0007275,GO:0007283,GO:0030154,GO:0042127,GO:0045595,GO:0046983,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|male germ cell nucleus|DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|transcription by RNA polymerase II|multicellular organism development|spermatogenesis|cell differentiation|regulation of cell population proliferation|regulation of cell differentiation|protein dimerization activity|sequence-specific double-stranded DNA binding" TCHP 628.9489696 614.8846046 643.0133346 1.045746356 0.064532971 0.809867257 1 8.997878048 9.252042969 84260 trichoplein keratin filament binding "GO:0005515,GO:0005737,GO:0005739,GO:0005813,GO:0005829,GO:0005886,GO:0006915,GO:0030030,GO:0030057,GO:0030308,GO:0045095,GO:0045179,GO:1902018" protein binding|cytoplasm|mitochondrion|centrosome|cytosol|plasma membrane|apoptotic process|cell projection organization|desmosome|negative regulation of cell growth|keratin filament|apical cortex|negative regulation of cilium assembly TCIM 13.32723566 21.84869154 4.80577978 0.219957327 -2.184704438 0.038276994 0.982059825 0.637520236 0.137880734 56892 transcriptional and immune response regulator "GO:0002264,GO:0005112,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006915,GO:0010739,GO:0016607,GO:0034605,GO:0043066,GO:0043620,GO:0045746,GO:1900020,GO:1901224,GO:1902806,GO:1903706" endothelial cell activation involved in immune response|Notch binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|apoptotic process|positive regulation of protein kinase A signaling|nuclear speck|cellular response to heat|negative regulation of apoptotic process|regulation of DNA-templated transcription in response to stress|negative regulation of Notch signaling pathway|positive regulation of protein kinase C activity|positive regulation of NIK/NF-kappaB signaling|regulation of cell cycle G1/S phase transition|regulation of hemopoiesis TCIRG1 1545.415705 1498.195991 1592.635419 1.06303543 0.088189681 0.713204379 1 18.88426228 19.73871795 10312 "T cell immune regulator 1, ATPase H+ transporting V0 subunit a3" "GO:0000045,GO:0000220,GO:0001503,GO:0002158,GO:0005215,GO:0005515,GO:0005634,GO:0005765,GO:0005770,GO:0005886,GO:0005887,GO:0006874,GO:0006915,GO:0006954,GO:0006968,GO:0007035,GO:0007039,GO:0008284,GO:0008286,GO:0010008,GO:0010155,GO:0010272,GO:0010467,GO:0010468,GO:0016064,GO:0016236,GO:0016324,GO:0016471,GO:0021554,GO:0030010,GO:0030183,GO:0030217,GO:0030316,GO:0030670,GO:0031529,GO:0033365,GO:0033572,GO:0034220,GO:0035709,GO:0035711,GO:0043029,GO:0043312,GO:0044691,GO:0045453,GO:0045667,GO:0046961,GO:0050796,GO:0051117,GO:0051650,GO:0060041,GO:0061484,GO:0070166,GO:0071345,GO:0090383,GO:0097188,GO:0101003,GO:1902600" "autophagosome assembly|vacuolar proton-transporting V-type ATPase, V0 domain|ossification|osteoclast proliferation|transporter activity|protein binding|nucleus|lysosomal membrane|late endosome|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|apoptotic process|inflammatory response|cellular defense response|vacuolar acidification|protein catabolic process in the vacuole|positive regulation of cell population proliferation|insulin receptor signaling pathway|endosome membrane|regulation of proton transport|response to silver ion|gene expression|regulation of gene expression|immunoglobulin mediated immune response|macroautophagy|apical plasma membrane|vacuolar proton-transporting V-type ATPase complex|optic nerve development|establishment of cell polarity|B cell differentiation|T cell differentiation|osteoclast differentiation|phagocytic vesicle membrane|ruffle organization|protein localization to organelle|transferrin transport|ion transmembrane transport|memory T cell activation|T-helper 1 cell activation|T cell homeostasis|neutrophil degranulation|tooth eruption|bone resorption|regulation of osteoblast differentiation|proton-transporting ATPase activity, rotational mechanism|regulation of insulin secretion|ATPase binding|establishment of vesicle localization|retina development in camera-type eye|hematopoietic stem cell homeostasis|enamel mineralization|cellular response to cytokine stimulus|phagosome acidification|dentin mineralization|ficolin-1-rich granule membrane|proton transmembrane transport" "hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323" Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis TCN2 57.48568942 58.26317743 56.7082014 0.97331117 -0.039026983 0.979599862 1 1.47295059 1.409649251 6948 transcobalamin 2 "GO:0005515,GO:0005576,GO:0005615,GO:0005768,GO:0006824,GO:0009235,GO:0015889,GO:0031419,GO:0043202,GO:0046872" protein binding|extracellular region|extracellular space|endosome|cobalt ion transport|cobalamin metabolic process|cobalamin transport|cobalamin binding|lysosomal lumen|metal ion binding hsa04977 Vitamin digestion and absorption TCOF1 2695.885631 2973.502877 2418.268385 0.81327259 -0.298189104 0.2073505 1 26.22548066 20.9715616 6949 treacle ribosome biogenesis factor 1 "GO:0001501,GO:0001650,GO:0003723,GO:0005215,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006417,GO:0014029,GO:0014032,GO:0030674,GO:0042790,GO:0046982,GO:0097110" skeletal system development|fibrillar center|RNA binding|transporter activity|protein binding|nucleoplasm|nucleolus|cytosol|regulation of translation|neural crest formation|neural crest cell development|protein-macromolecule adaptor activity|nucleolar large rRNA transcription by RNA polymerase I|protein heterodimerization activity|scaffold protein binding hsa03008 Ribosome biogenesis in eukaryotes TCP1 4229.077337 3898.430818 4559.723855 1.169630569 0.226052922 0.343418392 1 88.45752031 101.731313 6950 t-complex 1 "GO:0000242,GO:0000792,GO:0001669,GO:0002199,GO:0003723,GO:0005515,GO:0005524,GO:0005794,GO:0005813,GO:0005829,GO:0005832,GO:0005874,GO:0006457,GO:0007021,GO:0007339,GO:0031625,GO:0032212,GO:0035722,GO:0044053,GO:0044183,GO:0044297,GO:0050821,GO:0051082,GO:0051973,GO:0070062,GO:0090666,GO:1901998,GO:1904851,GO:1904871,GO:1904874,GO:2000109" pericentriolar material|heterochromatin|acrosomal vesicle|zona pellucida receptor complex|RNA binding|protein binding|ATP binding|Golgi apparatus|centrosome|cytosol|chaperonin-containing T-complex|microtubule|protein folding|tubulin complex assembly|binding of sperm to zona pellucida|ubiquitin protein ligase binding|positive regulation of telomere maintenance via telomerase|interleukin-12-mediated signaling pathway|translocation of peptides or proteins into host cell cytoplasm|protein folding chaperone|cell body|protein stabilization|unfolded protein binding|positive regulation of telomerase activity|extracellular exosome|scaRNA localization to Cajal body|toxin transport|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body|regulation of macrophage apoptotic process TCP11 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.064190725 0.058308407 6954 t-complex 11 "GO:0001669,GO:0007165,GO:0007275,GO:0007283,GO:0010737,GO:0016021,GO:0030154,GO:0036126,GO:0043949,GO:0097225,GO:1902490" acrosomal vesicle|signal transduction|multicellular organism development|spermatogenesis|protein kinase A signaling|integral component of membrane|cell differentiation|sperm flagellum|regulation of cAMP-mediated signaling|sperm midpiece|regulation of sperm capacitation TCP11L1 1261.707964 1216.243829 1307.1721 1.074761548 0.104016612 0.668319224 1 6.945077871 7.339397647 55346 t-complex 11 like 1 "GO:0005515,GO:0005874,GO:0007165" protein binding|microtubule|signal transduction TCP11L2 187.8651317 200.7998793 174.930384 0.871167774 -0.198977507 0.600736472 1 2.049009657 1.755161103 255394 t-complex 11 like 2 "GO:0005515,GO:0007165" protein binding|signal transduction TCTA 284.6688965 281.9521622 287.3856308 1.019270888 0.027537523 0.943480008 1 7.008508938 7.024031177 6988 T cell leukemia translocation altered "GO:0003674,GO:0005515,GO:0016021,GO:0045671,GO:0072675" molecular_function|protein binding|integral component of membrane|negative regulation of osteoclast differentiation|osteoclast fusion TCTN1 339.3006862 366.2256867 312.3756857 0.852959519 -0.229450821 0.452067536 1 7.403330229 6.209072355 79600 tectonic family member 1 "GO:0001701,GO:0001841,GO:0005615,GO:0005829,GO:0005856,GO:0008589,GO:0016020,GO:0021523,GO:0021537,GO:0021904,GO:0021956,GO:0036038,GO:0060271,GO:0097711,GO:1904491" in utero embryonic development|neural tube formation|extracellular space|cytosol|cytoskeleton|regulation of smoothened signaling pathway|membrane|somatic motor neuron differentiation|telencephalon development|dorsal/ventral neural tube patterning|central nervous system interneuron axonogenesis|MKS complex|cilium assembly|ciliary basal body-plasma membrane docking|protein localization to ciliary transition zone TCTN2 510.5789464 484.8328693 536.3250234 1.106205988 0.145620057 0.596341624 1 8.882471387 9.661420864 79867 tectonic family member 2 "GO:0005737,GO:0005856,GO:0007224,GO:0016021,GO:0036038,GO:0060170,GO:0060271,GO:0097711,GO:1904491" cytoplasm|cytoskeleton|smoothened signaling pathway|integral component of membrane|MKS complex|ciliary membrane|cilium assembly|ciliary basal body-plasma membrane docking|protein localization to ciliary transition zone TCTN3 2075.088823 2004.877552 2145.300094 1.070040458 0.097665346 0.680889371 1 42.49270458 44.70805239 26123 tectonic family member 3 "GO:0005515,GO:0005634,GO:0006915,GO:0007224,GO:0016021,GO:0043065,GO:0060170,GO:0060271,GO:0097711" protein binding|nucleus|apoptotic process|smoothened signaling pathway|integral component of membrane|positive regulation of apoptotic process|ciliary membrane|cilium assembly|ciliary basal body-plasma membrane docking TDG 380.9373632 399.5189309 362.3557954 0.906980289 -0.140856897 0.636227589 1 6.6360383 5.918040205 6996 thymine DNA glycosylase "GO:0000122,GO:0000287,GO:0003677,GO:0003684,GO:0003690,GO:0004844,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005886,GO:0006284,GO:0006285,GO:0006298,GO:0006325,GO:0008134,GO:0008263,GO:0019104,GO:0019904,GO:0030983,GO:0031402,GO:0031404,GO:0032183,GO:0035511,GO:0040029,GO:0042803,GO:0043621,GO:0043739,GO:0045008,GO:0045995,GO:0080111,GO:1902544" "negative regulation of transcription by RNA polymerase II|magnesium ion binding|DNA binding|damaged DNA binding|double-stranded DNA binding|uracil DNA N-glycosylase activity|protein binding|ATP binding|nucleus|nucleoplasm|plasma membrane|base-excision repair|base-excision repair, AP site formation|mismatch repair|chromatin organization|transcription factor binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity|DNA N-glycosylase activity|protein domain specific binding|mismatched DNA binding|sodium ion binding|chloride ion binding|SUMO binding|oxidative DNA demethylation|regulation of gene expression, epigenetic|protein homodimerization activity|protein self-association|G/U mismatch-specific uracil-DNA glycosylase activity|depyrimidination|regulation of embryonic development|DNA demethylation|regulation of DNA N-glycosylase activity" hsa03410 Base excision repair TDO2 1.922311912 0 3.844623824 Inf Inf 0.288176591 1 0 0.118674758 6999 "tryptophan 2,3-dioxygenase" "GO:0004833,GO:0005515,GO:0005829,GO:0006569,GO:0016597,GO:0019441,GO:0019442,GO:0019825,GO:0020037,GO:0042802,GO:0046872,GO:0051289,GO:0055114,GO:1904842" "tryptophan 2,3-dioxygenase activity|protein binding|cytosol|tryptophan catabolic process|amino acid binding|tryptophan catabolic process to kynurenine|tryptophan catabolic process to acetyl-CoA|oxygen binding|heme binding|identical protein binding|metal ion binding|protein homotetramerization|oxidation-reduction process|response to nitroglycerin" hsa00380 Tryptophan metabolism TDP1 997.0447055 980.0698774 1014.019534 1.034640036 0.049128924 0.845407457 1 9.930610987 10.10267607 55775 tyrosyl-DNA phosphodiesterase 1 "GO:0000012,GO:0003690,GO:0003697,GO:0004527,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0006281,GO:0006302,GO:0017005,GO:0043231,GO:0090305" single strand break repair|double-stranded DNA binding|single-stranded DNA binding|exonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|plasma membrane|DNA repair|double-strand break repair|3'-tyrosyl-DNA phosphodiesterase activity|intracellular membrane-bounded organelle|nucleic acid phosphodiester bond hydrolysis TDP2 702.0358368 716.8451651 687.2265085 0.958681933 -0.060875851 0.817010849 1 19.77090902 18.63684353 51567 tyrosyl-DNA phosphodiesterase 2 "GO:0000287,GO:0003697,GO:0003714,GO:0004518,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006302,GO:0007166,GO:0016032,GO:0016235,GO:0016604,GO:0016605,GO:0030145,GO:0036317,GO:0045892,GO:0048666,GO:0070260,GO:0090305" "magnesium ion binding|single-stranded DNA binding|transcription corepressor activity|nuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|double-strand break repair|cell surface receptor signaling pathway|viral process|aggresome|nuclear body|PML body|manganese ion binding|tyrosyl-RNA phosphodiesterase activity|negative regulation of transcription, DNA-templated|neuron development|5'-tyrosyl-DNA phosphodiesterase activity|nucleic acid phosphodiester bond hydrolysis" TDRD3 304.2090473 290.2754733 318.1426214 1.096002421 0.132250985 0.680112671 1 4.338131757 4.675041067 81550 tudor domain containing 3 "GO:0003682,GO:0003713,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006325,GO:0035064,GO:0035145,GO:0045893" "chromatin binding|transcription coactivator activity|RNA binding|protein binding|nucleus|nucleoplasm|Golgi apparatus|cytosol|chromatin organization|methylated histone binding|exon-exon junction complex|positive regulation of transcription, DNA-templated" TDRD6 4.082397604 6.242483296 1.922311912 0.307940257 -1.699277611 0.406294648 1 0.037152878 0.01124942 221400 tudor domain containing 6 "GO:0005737,GO:0007275,GO:0007283,GO:0030154,GO:0033391" cytoplasm|multicellular organism development|spermatogenesis|cell differentiation|chromatoid body TDRD7 929.4178031 844.8160727 1014.019534 1.200284377 0.263376256 0.287780205 1 12.22513045 14.42808971 23424 tudor domain containing 7 "GO:0002089,GO:0003729,GO:0005515,GO:0005737,GO:0005759,GO:0007283,GO:0010608,GO:0033391,GO:0035770,GO:0047485,GO:0070306" lens morphogenesis in camera-type eye|mRNA binding|protein binding|cytoplasm|mitochondrial matrix|spermatogenesis|posttranscriptional regulation of gene expression|chromatoid body|ribonucleoprotein granule|protein N-terminus binding|lens fiber cell differentiation TDRKH 588.4068123 648.1778489 528.6357758 0.81557211 -0.294115655 0.265565305 1 7.899534253 6.334830966 11022 tudor and KH domain containing "GO:0003723,GO:0005515,GO:0005739,GO:0007140,GO:0007283,GO:0009566,GO:0030154,GO:0031047,GO:0034587,GO:0043046,GO:0071546,GO:0071547" RNA binding|protein binding|mitochondrion|male meiotic nuclear division|spermatogenesis|fertilization|cell differentiation|gene silencing by RNA|piRNA metabolic process|DNA methylation involved in gamete generation|pi-body|piP-body TEAD1 4293.416994 4439.446037 4147.38795 0.934212944 -0.098176661 0.68130381 1 25.15929443 23.11082858 7003 TEA domain transcription factor 1 "GO:0000785,GO:0000978,GO:0000981,GO:0000987,GO:0003677,GO:0003700,GO:0005515,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0035329,GO:0045893,GO:0045944,GO:0048568,GO:0065003,GO:0140552,GO:1902895,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA binding|DNA-binding transcription factor activity|protein binding|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|hippo signaling|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|embryonic organ development|protein-containing complex assembly|TEAD-YAP complex|positive regulation of pri-miRNA transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species TEA TEAD2 409.8066404 413.0443114 406.5689694 0.984322888 -0.022796454 0.945914078 1 7.533634913 7.291440434 8463 TEA domain transcription factor 2 "GO:0000785,GO:0000978,GO:0000981,GO:0001223,GO:0001570,GO:0001843,GO:0003143,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006355,GO:0006357,GO:0006367,GO:0030903,GO:0035329,GO:0043231,GO:0045893,GO:0045944,GO:0048339,GO:0048368,GO:0048568,GO:0060548,GO:0065003,GO:0071300,GO:0097718,GO:0140552,GO:1990837,GO:2000736" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|transcription coactivator binding|vasculogenesis|neural tube closure|embryonic heart tube morphogenesis|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|notochord development|hippo signaling|intracellular membrane-bounded organelle|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|paraxial mesoderm development|lateral mesoderm development|embryonic organ development|negative regulation of cell death|protein-containing complex assembly|cellular response to retinoic acid|disordered domain specific binding|TEAD-YAP complex|sequence-specific double-stranded DNA binding|regulation of stem cell differentiation" "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species TEAD3 487.6848105 451.5396251 523.829996 1.160097513 0.214246077 0.438117087 1 8.07027458 9.205639965 7005 TEA domain transcription factor 3 "GO:0000785,GO:0000978,GO:0000981,GO:0001085,GO:0003700,GO:0005515,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0007565,GO:0035329,GO:0045944,GO:0048568,GO:0055059" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|DNA-binding transcription factor activity|protein binding|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|female pregnancy|hippo signaling|positive regulation of transcription by RNA polymerase II|embryonic organ development|asymmetric neuroblast division" "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species TEAD4 755.6869633 750.1384094 761.2355171 1.014793414 0.021186061 0.938976464 1 23.23476971 23.18393715 7004 TEA domain transcription factor 4 "GO:0000785,GO:0000978,GO:0000981,GO:0001501,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0007517,GO:0035329,GO:0048568" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|skeletal system development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|muscle organ development|hippo signaling|embryonic organ development" "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species TEA TEC 209.8974911 186.234085 233.5608973 1.254125405 0.326681616 0.362945318 1 1.877048316 2.314662074 7006 tec protein tyrosine kinase "GO:0002250,GO:0004715,GO:0005515,GO:0005524,GO:0005543,GO:0005829,GO:0005856,GO:0005886,GO:0006468,GO:0007229,GO:0010543,GO:0018108,GO:0019221,GO:0035556,GO:0038083,GO:0038095,GO:0042246,GO:0046872,GO:0050731,GO:0050852,GO:0050853" adaptive immune response|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|phospholipid binding|cytosol|cytoskeleton|plasma membrane|protein phosphorylation|integrin-mediated signaling pathway|regulation of platelet activation|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|intracellular signal transduction|peptidyl-tyrosine autophosphorylation|Fc-epsilon receptor signaling pathway|tissue regeneration|metal ion binding|positive regulation of peptidyl-tyrosine phosphorylation|T cell receptor signaling pathway|B cell receptor signaling pathway "hsa04380,hsa04660" Osteoclast differentiation|T cell receptor signaling pathway TECPR1 607.36762 603.4400519 611.295188 1.01301726 0.018658755 0.950132775 1 4.877989472 4.858798428 25851 tectonin beta-propeller repeat containing 1 "GO:0000421,GO:0005515,GO:0005654,GO:0005765,GO:0006914,GO:0016021,GO:0031410,GO:0032266,GO:0043231,GO:0097352" autophagosome membrane|protein binding|nucleoplasm|lysosomal membrane|autophagy|integral component of membrane|cytoplasmic vesicle|phosphatidylinositol-3-phosphate binding|intracellular membrane-bounded organelle|autophagosome maturation hsa05131 Shigellosis TECPR2 473.2920089 490.0349387 456.5490791 0.931666383 -0.102114656 0.717849287 1 2.884971212 2.642853488 9895 tectonin beta-propeller repeat containing 2 "GO:0005515,GO:0005737,GO:0006914,GO:0032527" protein binding|cytoplasm|autophagy|protein exit from endoplasmic reticulum TECR 1224.193928 1089.313335 1359.074522 1.247643335 0.319205568 0.186795892 1 35.64356261 43.7263005 9524 "trans-2,3-enoyl-CoA reductase" "GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0006665,GO:0016491,GO:0030176,GO:0030497,GO:0035338,GO:0042761,GO:0055114,GO:0102758" protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|sphingolipid metabolic process|oxidoreductase activity|integral component of endoplasmic reticulum membrane|fatty acid elongation|long-chain fatty-acyl-CoA biosynthetic process|very long-chain fatty acid biosynthetic process|oxidation-reduction process|very-long-chain enoyl-CoA reductase activity "hsa00062,hsa01040" Fatty acid elongation|Biosynthesis of unsaturated fatty acids TEDC1 286.6604055 309.0029231 264.3178879 0.855389603 -0.225346422 0.485804053 1 7.322787782 6.159019716 283643 tubulin epsilon and delta complex 1 "GO:0005515,GO:0005737,GO:0005814,GO:0005929,GO:0045880" protein binding|cytoplasm|centriole|cilium|positive regulation of smoothened signaling pathway TEDC2 249.8345387 263.2247123 236.4443652 0.898260513 -0.154794179 0.65157097 1 8.602461182 7.597946112 80178 tubulin epsilon and delta complex 2 "GO:0005515,GO:0005737,GO:0005814,GO:0005929,GO:0045880" protein binding|cytoplasm|centriole|cilium|positive regulation of smoothened signaling pathway TEF 305.085915 300.6796121 309.4922178 1.029308957 0.041676086 0.904825906 1 3.545452557 3.588298873 7008 "TEF transcription factor, PAR bZIP family member" "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0048511,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|rhythmic process|sequence-specific double-stranded DNA binding" TEFM 192.9929736 196.6382238 189.3477233 0.962924296 -0.054505715 0.896544916 1 3.88674837 3.680016354 79736 "transcription elongation factor, mitochondrial" "GO:0003723,GO:0005515,GO:0005739,GO:0005759,GO:0006119,GO:0006259,GO:0006264,GO:0006390,GO:0006392,GO:0008821,GO:0030337,GO:0042645,GO:0050790,GO:1990904" RNA binding|protein binding|mitochondrion|mitochondrial matrix|oxidative phosphorylation|DNA metabolic process|mitochondrial DNA replication|mitochondrial transcription|transcription elongation from mitochondrial promoter|crossover junction endodeoxyribonuclease activity|DNA polymerase processivity factor activity|mitochondrial nucleoid|regulation of catalytic activity|ribonucleoprotein complex TEK 2.080827765 4.161655531 0 0 #NAME? 0.234194363 1 0.046620467 0 7010 TEK receptor tyrosine kinase "GO:0000165,GO:0001525,GO:0001666,GO:0001725,GO:0001934,GO:0001935,GO:0001938,GO:0001958,GO:0002040,GO:0004672,GO:0004713,GO:0004714,GO:0005515,GO:0005524,GO:0005576,GO:0005737,GO:0005884,GO:0005886,GO:0005887,GO:0005902,GO:0005911,GO:0005925,GO:0007165,GO:0007169,GO:0007267,GO:0007275,GO:0007507,GO:0009925,GO:0009986,GO:0010595,GO:0014068,GO:0016323,GO:0016324,GO:0016525,GO:0018108,GO:0019838,GO:0032878,GO:0033674,GO:0034446,GO:0034451,GO:0038023,GO:0042802,GO:0043066,GO:0043114,GO:0043235,GO:0043410,GO:0043434,GO:0043552,GO:0043627,GO:0045121,GO:0045766,GO:0046777,GO:0048014,GO:0050728,GO:0050900,GO:0051591,GO:0051894,GO:0051897,GO:0060216,GO:0060347,GO:0070374,GO:0072012,GO:1902533,GO:2000251,GO:2000351,GO:2000352" MAPK cascade|angiogenesis|response to hypoxia|stress fiber|positive regulation of protein phosphorylation|endothelial cell proliferation|positive regulation of endothelial cell proliferation|endochondral ossification|sprouting angiogenesis|protein kinase activity|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|protein binding|ATP binding|extracellular region|cytoplasm|actin filament|plasma membrane|integral component of plasma membrane|microvillus|cell-cell junction|focal adhesion|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|cell-cell signaling|multicellular organism development|heart development|basal plasma membrane|cell surface|positive regulation of endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase signaling|basolateral plasma membrane|apical plasma membrane|negative regulation of angiogenesis|peptidyl-tyrosine phosphorylation|growth factor binding|regulation of establishment or maintenance of cell polarity|positive regulation of kinase activity|substrate adhesion-dependent cell spreading|centriolar satellite|signaling receptor activity|identical protein binding|negative regulation of apoptotic process|regulation of vascular permeability|receptor complex|positive regulation of MAPK cascade|response to peptide hormone|positive regulation of phosphatidylinositol 3-kinase activity|response to estrogen|membrane raft|positive regulation of angiogenesis|protein autophosphorylation|Tie signaling pathway|negative regulation of inflammatory response|leukocyte migration|response to cAMP|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|definitive hemopoiesis|heart trabecula formation|positive regulation of ERK1 and ERK2 cascade|glomerulus vasculature development|positive regulation of intracellular signal transduction|positive regulation of actin cytoskeleton reorganization|regulation of endothelial cell apoptotic process|negative regulation of endothelial cell apoptotic process "hsa04010,hsa04014,hsa04015,hsa04066,hsa04151,hsa05323" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|HIF-1 signaling pathway|PI3K-Akt signaling pathway|Rheumatoid arthritis TEKT2 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.100346343 0.091150793 27285 tektin 2 "GO:0005634,GO:0005737,GO:0005815,GO:0005874,GO:0015630,GO:0030317,GO:0031514,GO:0036159,GO:0060271,GO:0060294" nucleus|cytoplasm|microtubule organizing center|microtubule|microtubule cytoskeleton|flagellated sperm motility|motile cilium|inner dynein arm assembly|cilium assembly|cilium movement involved in cell motility TELO2 504.2817429 508.7623886 499.8010971 0.982386097 -0.025637952 0.93281587 1 6.822038597 6.589729052 9894 telomere maintenance 2 "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007004,GO:0016020,GO:0016604,GO:0019901,GO:0031931,GO:0031932,GO:0032006,GO:0034399,GO:0042162,GO:0044877,GO:0050821,GO:0051879,GO:0060090,GO:0070209,GO:0071902,GO:1904263,GO:1904515" protein binding|nucleus|cytoplasm|cytosol|telomere maintenance via telomerase|membrane|nuclear body|protein kinase binding|TORC1 complex|TORC2 complex|regulation of TOR signaling|nuclear periphery|telomeric DNA binding|protein-containing complex binding|protein stabilization|Hsp90 protein binding|molecular adaptor activity|ASTRA complex|positive regulation of protein serine/threonine kinase activity|positive regulation of TORC1 signaling|positive regulation of TORC2 signaling "hsa03460,hsa04150" Fanconi anemia pathway|mTOR signaling pathway TEN1 164.0148703 155.0216685 173.0080721 1.116025093 0.158369466 0.697396476 1 8.49406728 9.320964091 100134934 TEN1 subunit of CST complex "GO:0000781,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0010521,GO:0016233,GO:0032211,GO:0042162,GO:0051974,GO:1990879" "chromosome, telomeric region|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|telomerase inhibitor activity|telomere capping|negative regulation of telomere maintenance via telomerase|telomeric DNA binding|negative regulation of telomerase activity|CST complex" TENM1 91.62120273 121.7284243 61.51398118 0.505337858 -0.984679829 0.041444059 1 0.417668913 0.207532045 10178 teneurin transmembrane protein 1 "GO:0005576,GO:0005634,GO:0005737,GO:0005783,GO:0005794,GO:0005856,GO:0005886,GO:0005887,GO:0006359,GO:0006955,GO:0007157,GO:0007218,GO:0007399,GO:0008201,GO:0008285,GO:0016363,GO:0016607,GO:0030838,GO:0033138,GO:0042803,GO:0043005,GO:0043406,GO:0046982,GO:0048471,GO:0048666,GO:0050839,GO:0051491,GO:0090316" extracellular region|nucleus|cytoplasm|endoplasmic reticulum|Golgi apparatus|cytoskeleton|plasma membrane|integral component of plasma membrane|regulation of transcription by RNA polymerase III|immune response|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|neuropeptide signaling pathway|nervous system development|heparin binding|negative regulation of cell population proliferation|nuclear matrix|nuclear speck|positive regulation of actin filament polymerization|positive regulation of peptidyl-serine phosphorylation|protein homodimerization activity|neuron projection|positive regulation of MAP kinase activity|protein heterodimerization activity|perinuclear region of cytoplasm|neuron development|cell adhesion molecule binding|positive regulation of filopodium assembly|positive regulation of intracellular protein transport TENM2 10.52805613 11.44455271 9.61155956 0.839837065 -0.251818634 0.906931683 1 0.037641732 0.031083922 57451 teneurin transmembrane protein 2 "GO:0000122,GO:0005509,GO:0005634,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0007157,GO:0007165,GO:0016605,GO:0030054,GO:0030175,GO:0030425,GO:0030426,GO:0042803,GO:0043005,GO:0043197,GO:0045202,GO:0045211,GO:0046982,GO:0048666,GO:0050839,GO:0051491,GO:0098609" negative regulation of transcription by RNA polymerase II|calcium ion binding|nucleus|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|signal transduction|PML body|cell junction|filopodium|dendrite|growth cone|protein homodimerization activity|neuron projection|dendritic spine|synapse|postsynaptic membrane|protein heterodimerization activity|neuron development|cell adhesion molecule binding|positive regulation of filopodium assembly|cell-cell adhesion TENM3 536.1628213 601.3592242 470.9664184 0.783169858 -0.352602853 0.190028831 1 2.747490501 2.115745095 55714 teneurin transmembrane protein 3 "GO:0005887,GO:0007156,GO:0007157,GO:0007165,GO:0010976,GO:0016020,GO:0030424,GO:0042803,GO:0043005,GO:0046982,GO:0048593,GO:0048666,GO:0050839,GO:1903385" integral component of plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|signal transduction|positive regulation of neuron projection development|membrane|axon|protein homodimerization activity|neuron projection|protein heterodimerization activity|camera-type eye morphogenesis|neuron development|cell adhesion molecule binding|regulation of homophilic cell adhesion TENM4 126.4851286 166.4662212 86.50403604 0.519649184 -0.944390108 0.028650926 0.882435626 0.553761533 0.282946426 26011 teneurin transmembrane protein 4 "GO:0001702,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0005887,GO:0007157,GO:0007165,GO:0031641,GO:0031643,GO:0032289,GO:0042803,GO:0043005,GO:0046982,GO:0048666,GO:0048714,GO:0050839,GO:0060038,GO:0060912,GO:2000543" gastrulation with mouth forming second|protein binding|nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|signal transduction|regulation of myelination|positive regulation of myelination|central nervous system myelin formation|protein homodimerization activity|neuron projection|protein heterodimerization activity|neuron development|positive regulation of oligodendrocyte differentiation|cell adhesion molecule binding|cardiac muscle cell proliferation|cardiac cell fate specification|positive regulation of gastrulation TENT2 1220.79467 1176.708101 1264.881238 1.074932039 0.10424545 0.66849723 1 13.16535611 13.91505082 167153 terminal nucleotidyltransferase 2 "GO:0002244,GO:0004652,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006378,GO:0006397,GO:0016779,GO:0021766,GO:0030182,GO:0031380,GO:0034062,GO:0043489,GO:0043631,GO:0046872,GO:0060041,GO:0070566,GO:0071044,GO:1990603,GO:2000626" hematopoietic progenitor cell differentiation|polynucleotide adenylyltransferase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|mRNA polyadenylation|mRNA processing|nucleotidyltransferase activity|hippocampus development|neuron differentiation|nuclear RNA-directed RNA polymerase complex|5'-3' RNA polymerase activity|RNA stabilization|RNA polyadenylation|metal ion binding|retina development in camera-type eye|adenylyltransferase activity|histone mRNA catabolic process|dark adaptation|negative regulation of miRNA catabolic process TENT4A 1305.588401 1346.295564 1264.881238 0.939527153 -0.089993238 0.710525935 1 9.031969814 8.343782832 11044 terminal nucleotidyltransferase 4A "GO:0004652,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005794,GO:0006302,GO:0006397,GO:0007062,GO:0007076,GO:0031123,GO:0031499,GO:0031965,GO:0042493,GO:0043221,GO:0043631,GO:0046872,GO:0060212,GO:0070568,GO:0071076,GO:1905870" polynucleotide adenylyltransferase activity|ATP binding|nucleus|nucleoplasm|nucleolus|Golgi apparatus|double-strand break repair|mRNA processing|sister chromatid cohesion|mitotic chromosome condensation|RNA 3'-end processing|TRAMP complex|nuclear membrane|response to drug|SMC family protein binding|RNA polyadenylation|metal ion binding|negative regulation of nuclear-transcribed mRNA poly(A) tail shortening|guanylyltransferase activity|RNA 3' uridylation|positive regulation of 3'-UTR-mediated mRNA stabilization hsa03018 RNA degradation TENT4B 430.2481965 470.267075 390.2293181 0.829803614 -0.269158155 0.343931963 1 2.931241471 2.391652602 64282 terminal nucleotidyltransferase 4B "GO:0003677,GO:0003723,GO:0003887,GO:0004652,GO:0005515,GO:0005730,GO:0005737,GO:0006364,GO:0006378,GO:0007049,GO:0010587,GO:0031123,GO:0031499,GO:0032211,GO:0033500,GO:0043629,GO:0043630,GO:0046872,GO:0051301,GO:0060212,GO:0070034,GO:0070568,GO:0071044,GO:0071050,GO:0071076,GO:0071897,GO:1905870" DNA binding|RNA binding|DNA-directed DNA polymerase activity|polynucleotide adenylyltransferase activity|protein binding|nucleolus|cytoplasm|rRNA processing|mRNA polyadenylation|cell cycle|miRNA catabolic process|RNA 3'-end processing|TRAMP complex|negative regulation of telomere maintenance via telomerase|carbohydrate homeostasis|ncRNA polyadenylation|ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process|metal ion binding|cell division|negative regulation of nuclear-transcribed mRNA poly(A) tail shortening|telomerase RNA binding|guanylyltransferase activity|histone mRNA catabolic process|sno(s)RNA polyadenylation|RNA 3' uridylation|DNA biosynthetic process|positive regulation of 3'-UTR-mediated mRNA stabilization hsa03018 RNA degradation TENT5A 137.4641946 151.9004269 123.0279624 0.80992506 -0.304139669 0.473589662 1 1.452283519 1.156558019 55603 terminal nucleotidyltransferase 5A "GO:0003723,GO:0005515,GO:0048255,GO:1990817" RNA binding|protein binding|mRNA stabilization|RNA adenylyltransferase activity TENT5B 118.0083321 133.172977 102.8436873 0.772256426 -0.372848124 0.403127374 1 2.983709916 2.265631672 115572 terminal nucleotidyltransferase 5B "GO:0005515,GO:0048255,GO:1990817" protein binding|mRNA stabilization|RNA adenylyltransferase activity TENT5C 10.60731406 13.52538047 7.689247648 0.56850509 -0.814754828 0.49718369 1 0.1276662 0.071364375 54855 terminal nucleotidyltransferase 5C "GO:0001701,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0016032,GO:0048255,GO:1990817" in utero embryonic development|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|viral process|mRNA stabilization|RNA adenylyltransferase activity TEP1 670.3076295 741.8150983 598.8001606 0.807209454 -0.308985023 0.231112431 1 3.671796364 2.91431174 7011 telomerase associated protein 1 "GO:0000722,GO:0000781,GO:0002039,GO:0003720,GO:0003723,GO:0005515,GO:0005524,GO:0005697,GO:0005737,GO:0006278,GO:0016363,GO:0019899,GO:0070034,GO:1990904" "telomere maintenance via recombination|chromosome, telomeric region|p53 binding|telomerase activity|RNA binding|protein binding|ATP binding|telomerase holoenzyme complex|cytoplasm|RNA-dependent DNA biosynthetic process|nuclear matrix|enzyme binding|telomerase RNA binding|ribonucleoprotein complex" TEPSIN 260.3179355 286.1138177 234.5220533 0.819680976 -0.286865581 0.38790237 1 4.193729359 3.379997928 146705 TEPSIN adaptor related protein complex 4 accessory protein "GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0016607,GO:0030124,GO:0030662,GO:0031312,GO:0031965,GO:0032588" protein binding|cytoplasm|Golgi apparatus|cytosol|nuclear speck|AP-4 adaptor complex|coated vesicle membrane|extrinsic component of organelle membrane|nuclear membrane|trans-Golgi network membrane TERF1 1038.943694 1058.100919 1019.786469 0.963789419 -0.053210133 0.831570506 1 18.03542042 17.09147732 7013 telomeric repeat binding factor 1 "GO:0000723,GO:0000781,GO:0000783,GO:0001650,GO:0003677,GO:0003691,GO:0003720,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005819,GO:0007004,GO:0007049,GO:0008017,GO:0008156,GO:0008301,GO:0016233,GO:0016604,GO:0032211,GO:0032214,GO:0042162,GO:0042802,GO:0042803,GO:0051301,GO:0051974,GO:0061820,GO:0070187,GO:0071532,GO:0090656,GO:0098505,GO:1904357,GO:1904792,GO:1904850,GO:1904911,GO:1904914,GO:1905778,GO:1905839" "telomere maintenance|chromosome, telomeric region|nuclear telomere cap complex|fibrillar center|DNA binding|double-stranded telomeric DNA binding|telomerase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|spindle|telomere maintenance via telomerase|cell cycle|microtubule binding|negative regulation of DNA replication|DNA binding, bending|telomere capping|nuclear body|negative regulation of telomere maintenance via telomerase|negative regulation of telomere maintenance via semi-conservative replication|telomeric DNA binding|identical protein binding|protein homodimerization activity|cell division|negative regulation of telomerase activity|telomeric D-loop disassembly|shelterin complex|ankyrin repeat binding|t-circle formation|G-rich strand telomeric DNA binding|negative regulation of telomere maintenance via telomere lengthening|positive regulation of shelterin complex assembly|negative regulation of establishment of protein localization to telomere|negative regulation of establishment of RNA localization to telomere|negative regulation of establishment of protein-containing complex localization to telomere|negative regulation of exonuclease activity|negative regulation of telomeric D-loop disassembly" MYB TERF2 685.7754435 718.9259929 652.6248941 0.907777575 -0.139589246 0.589947934 1 12.78073248 11.40791753 7014 telomeric repeat binding factor 2 "GO:0000723,GO:0000781,GO:0000783,GO:0001673,GO:0001701,GO:0003691,GO:0003720,GO:0005515,GO:0005634,GO:0005654,GO:0006278,GO:0007049,GO:0008022,GO:0010628,GO:0010629,GO:0016233,GO:0016604,GO:0019899,GO:0030870,GO:0031627,GO:0031848,GO:0032204,GO:0032205,GO:0032206,GO:0032208,GO:0032210,GO:0032211,GO:0032214,GO:0042162,GO:0042803,GO:0044877,GO:0051000,GO:0061820,GO:0070187,GO:0070198,GO:0090398,GO:0098505,GO:0099087,GO:1903770,GO:1903824,GO:1904115,GO:1904354,GO:1904357,GO:1904430,GO:1905778,GO:1905839,GO:2000773" "telomere maintenance|chromosome, telomeric region|nuclear telomere cap complex|male germ cell nucleus|in utero embryonic development|double-stranded telomeric DNA binding|telomerase activity|protein binding|nucleus|nucleoplasm|RNA-dependent DNA biosynthetic process|cell cycle|protein C-terminus binding|positive regulation of gene expression|negative regulation of gene expression|telomere capping|nuclear body|enzyme binding|Mre11 complex|telomeric loop formation|protection from non-homologous end joining at telomere|regulation of telomere maintenance|negative regulation of telomere maintenance|positive regulation of telomere maintenance|negative regulation of telomere maintenance via recombination|regulation of telomere maintenance via telomerase|negative regulation of telomere maintenance via telomerase|negative regulation of telomere maintenance via semi-conservative replication|telomeric DNA binding|protein homodimerization activity|protein-containing complex binding|positive regulation of nitric-oxide synthase activity|telomeric D-loop disassembly|shelterin complex|protein localization to chromosome, telomeric region|cellular senescence|G-rich strand telomeric DNA binding|anterograde axonal transport of messenger ribonucleoprotein complex|negative regulation of beta-galactosidase activity|negative regulation of telomere single strand break repair|axon cytoplasm|negative regulation of telomere capping|negative regulation of telomere maintenance via telomere lengthening|negative regulation of t-circle formation|negative regulation of exonuclease activity|negative regulation of telomeric D-loop disassembly|negative regulation of cellular senescence" TERF2IP 1233.290311 1075.787955 1390.792668 1.292813014 0.370513626 0.125200955 1 26.94172967 34.24777551 54386 TERF2 interacting protein "GO:0000228,GO:0000723,GO:0000781,GO:0000783,GO:0001933,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0007004,GO:0010569,GO:0010833,GO:0016233,GO:0016604,GO:0019902,GO:0030870,GO:0031848,GO:0032204,GO:0032205,GO:0033138,GO:0042162,GO:0043123,GO:0048239,GO:0051092,GO:0070187,GO:0070198,GO:0098505,GO:1901224,GO:1901985" "nuclear chromosome|telomere maintenance|chromosome, telomeric region|nuclear telomere cap complex|negative regulation of protein phosphorylation|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|telomere maintenance via telomerase|regulation of double-strand break repair via homologous recombination|telomere maintenance via telomere lengthening|telomere capping|nuclear body|phosphatase binding|Mre11 complex|protection from non-homologous end joining at telomere|regulation of telomere maintenance|negative regulation of telomere maintenance|positive regulation of peptidyl-serine phosphorylation|telomeric DNA binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of DNA recombination at telomere|positive regulation of NF-kappaB transcription factor activity|shelterin complex|protein localization to chromosome, telomeric region|G-rich strand telomeric DNA binding|positive regulation of NIK/NF-kappaB signaling|positive regulation of protein acetylation" TERT 321.9608644 264.2651262 379.6566026 1.436650413 0.522709046 0.089610135 1 3.491791059 4.932539015 7015 telomerase reverse transcriptase "GO:0000049,GO:0000333,GO:0000723,GO:0000781,GO:0000783,GO:0001172,GO:0001223,GO:0003677,GO:0003720,GO:0003721,GO:0003723,GO:0003964,GO:0003968,GO:0005515,GO:0005634,GO:0005654,GO:0005697,GO:0005730,GO:0005829,GO:0005886,GO:0006278,GO:0007004,GO:0007005,GO:0008022,GO:0010629,GO:0016605,GO:0016607,GO:0022616,GO:0030177,GO:0030422,GO:0031379,GO:0031647,GO:0032092,GO:0042162,GO:0042635,GO:0042645,GO:0042802,GO:0042803,GO:0043524,GO:0045766,GO:0046326,GO:0046686,GO:0046872,GO:0047485,GO:0051000,GO:0051087,GO:0062103,GO:0070034,GO:0070200,GO:0071456,GO:0071897,GO:0090399,GO:0098680,GO:1900087,GO:1902895,GO:1903620,GO:1903704,GO:1903799,GO:1904707,GO:1904751,GO:1904754,GO:1904837,GO:1990572,GO:2000352,GO:2000648,GO:2000773,GO:2001240" "tRNA binding|telomerase catalytic core complex|telomere maintenance|chromosome, telomeric region|nuclear telomere cap complex|transcription, RNA-templated|transcription coactivator binding|DNA binding|telomerase activity|telomerase RNA reverse transcriptase activity|RNA binding|RNA-directed DNA polymerase activity|RNA-directed 5'-3' RNA polymerase activity|protein binding|nucleus|nucleoplasm|telomerase holoenzyme complex|nucleolus|cytosol|plasma membrane|RNA-dependent DNA biosynthetic process|telomere maintenance via telomerase|mitochondrion organization|protein C-terminus binding|negative regulation of gene expression|PML body|nuclear speck|DNA strand elongation|positive regulation of Wnt signaling pathway|production of siRNA involved in RNA interference|RNA-directed RNA polymerase complex|regulation of protein stability|positive regulation of protein binding|telomeric DNA binding|positive regulation of hair cycle|mitochondrial nucleoid|identical protein binding|protein homodimerization activity|negative regulation of neuron apoptotic process|positive regulation of angiogenesis|positive regulation of glucose import|response to cadmium ion|metal ion binding|protein N-terminus binding|positive regulation of nitric-oxide synthase activity|chaperone binding|double-stranded RNA biosynthetic process|telomerase RNA binding|establishment of protein localization to telomere|cellular response to hypoxia|DNA biosynthetic process|replicative senescence|template-free RNA nucleotidyltransferase|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of transdifferentiation|negative regulation of production of siRNA involved in RNA interference|negative regulation of production of miRNAs involved in gene silencing by miRNA|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of protein localization to nucleolus|positive regulation of vascular associated smooth muscle cell migration|beta-catenin-TCF complex assembly|TERT-RMRP complex|negative regulation of endothelial cell apoptotic process|positive regulation of stem cell proliferation|negative regulation of cellular senescence|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa05165,hsa05166,hsa05200,hsa05225,hsa05226" Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Hepatocellular carcinoma|Gastric cancer TES 1995.376431 2145.333426 1845.419436 0.860201689 -0.217253132 0.358780298 1 40.74466263 34.46213628 26136 testin LIM domain protein "GO:0003723,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0005925,GO:0008270,GO:0008285,GO:0030054,GO:0032991,GO:0045296" RNA binding|protein binding|nucleus|cytosol|plasma membrane|focal adhesion|zinc ion binding|negative regulation of cell population proliferation|cell junction|protein-containing complex|cadherin binding TESC 3.443303773 2.080827765 4.80577978 2.309551929 1.207612985 0.648665767 1 0.107710915 0.244601224 54997 tescalcin "GO:0000287,GO:0001726,GO:0004860,GO:0005509,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006469,GO:0008285,GO:0008584,GO:0010628,GO:0015031,GO:0019212,GO:0030027,GO:0030219,GO:0030854,GO:0032417,GO:0032587,GO:0033628,GO:0042803,GO:0045654,GO:0045893,GO:0050821,GO:0051604,GO:0071300,GO:0072659" "magnesium ion binding|ruffle|protein kinase inhibitor activity|calcium ion binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|negative regulation of protein kinase activity|negative regulation of cell population proliferation|male gonad development|positive regulation of gene expression|protein transport|phosphatase inhibitor activity|lamellipodium|megakaryocyte differentiation|positive regulation of granulocyte differentiation|positive regulation of sodium:proton antiporter activity|ruffle membrane|regulation of cell adhesion mediated by integrin|protein homodimerization activity|positive regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-templated|protein stabilization|protein maturation|cellular response to retinoic acid|protein localization to plasma membrane" TESK1 882.7124205 867.7051781 897.7196629 1.034590648 0.049060056 0.847944917 1 18.30349035 18.61974126 7016 testis associated actin remodelling kinase 1 "GO:0001934,GO:0004672,GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0007283,GO:0008022,GO:0018108,GO:0019901,GO:0030036,GO:0031410,GO:0031953,GO:0032880,GO:0032956,GO:0042326,GO:0046872,GO:0048471,GO:0051496,GO:0051650,GO:0071901,GO:0090521,GO:1900026,GO:1900182,GO:1902018" positive regulation of protein phosphorylation|protein kinase activity|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|centrosome|cytosol|spermatogenesis|protein C-terminus binding|peptidyl-tyrosine phosphorylation|protein kinase binding|actin cytoskeleton organization|cytoplasmic vesicle|negative regulation of protein autophosphorylation|regulation of protein localization|regulation of actin cytoskeleton organization|negative regulation of phosphorylation|metal ion binding|perinuclear region of cytoplasm|positive regulation of stress fiber assembly|establishment of vesicle localization|negative regulation of protein serine/threonine kinase activity|glomerular visceral epithelial cell migration|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of protein localization to nucleus|negative regulation of cilium assembly TESK2 216.0110267 220.5677431 211.4543103 0.958681933 -0.060875851 0.875908728 1 3.833049516 3.613184604 10420 testis associated actin remodelling kinase 2 "GO:0004672,GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006468,GO:0007283,GO:0016604,GO:0018108,GO:0030036,GO:0046872,GO:0048041" protein kinase activity|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|protein phosphorylation|spermatogenesis|nuclear body|peptidyl-tyrosine phosphorylation|actin cytoskeleton organization|metal ion binding|focal adhesion assembly TESMIN 44.63903174 36.41448589 52.86357758 1.451718356 0.537761587 0.39912089 1 0.337040268 0.481099979 9633 testis expressed metallothionein like protein "GO:0005634,GO:0005737,GO:0006355,GO:0006875,GO:0007275,GO:0007283,GO:0010038,GO:0030154,GO:0046872" "nucleus|cytoplasm|regulation of transcription, DNA-templated|cellular metal ion homeostasis|multicellular organism development|spermatogenesis|response to metal ion|cell differentiation|metal ion binding" TET1 157.6484697 151.9004269 163.3965125 1.075681721 0.105251267 0.805481096 1 0.481049525 0.508797253 80312 tet methylcytosine dioxygenase 1 "GO:0001826,GO:0003677,GO:0005506,GO:0005634,GO:0006211,GO:0006325,GO:0006493,GO:0008270,GO:0008284,GO:0008327,GO:0019827,GO:0031062,GO:0045944,GO:0070579,GO:0070989,GO:0080111,GO:0090310" inner cell mass cell differentiation|DNA binding|iron ion binding|nucleus|5-methylcytosine catabolic process|chromatin organization|protein O-linked glycosylation|zinc ion binding|positive regulation of cell population proliferation|methyl-CpG binding|stem cell population maintenance|positive regulation of histone methylation|positive regulation of transcription by RNA polymerase II|methylcytosine dioxygenase activity|oxidative demethylation|DNA demethylation|negative regulation of DNA methylation-dependent heterochromatin assembly TET2 306.5125576 338.1345119 274.8906034 0.812962279 -0.298739681 0.340827999 1 1.617425601 1.292902832 54790 tet methylcytosine dioxygenase 2 "GO:0003677,GO:0005515,GO:0005634,GO:0006211,GO:0006493,GO:0007049,GO:0008198,GO:0008270,GO:0030099,GO:0045944,GO:0070579,GO:0070989,GO:0080111,GO:0080182" DNA binding|protein binding|nucleus|5-methylcytosine catabolic process|protein O-linked glycosylation|cell cycle|ferrous iron binding|zinc ion binding|myeloid cell differentiation|positive regulation of transcription by RNA polymerase II|methylcytosine dioxygenase activity|oxidative demethylation|DNA demethylation|histone H3-K4 trimethylation other TET3 400.3485663 429.6909335 371.006199 0.863425709 -0.211856044 0.466587958 1 1.570457155 1.33328271 200424 tet methylcytosine dioxygenase 3 "GO:0001939,GO:0001940,GO:0005515,GO:0005634,GO:0005694,GO:0005737,GO:0006211,GO:0006493,GO:0008270,GO:0008327,GO:0044727,GO:0045944,GO:0070579,GO:0070989,GO:0080111,GO:0080182" female pronucleus|male pronucleus|protein binding|nucleus|chromosome|cytoplasm|5-methylcytosine catabolic process|protein O-linked glycosylation|zinc ion binding|methyl-CpG binding|DNA demethylation of male pronucleus|positive regulation of transcription by RNA polymerase II|methylcytosine dioxygenase activity|oxidative demethylation|DNA demethylation|histone H3-K4 trimethylation TEX10 1227.041569 1277.628248 1176.45489 0.920811584 -0.119022113 0.624222174 1 21.8260792 19.76139865 54881 testis expressed 10 "GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0006364,GO:0071339,GO:0097344" protein binding|nucleoplasm|nucleolus|mitochondrion|rRNA processing|MLL1 complex|Rix1 complex TEX12 1.922311912 0 3.844623824 Inf Inf 0.288176591 1 0 0.176352351 56158 testis expressed 12 "GO:0000711,GO:0000801,GO:0005515,GO:0005694,GO:0007130" meiotic DNA repair synthesis|central element|protein binding|chromosome|synaptonemal complex assembly TEX14 9.329126399 5.202069413 13.45618338 2.586698161 1.371111717 0.266650381 1 0.052800472 0.134293422 56155 "testis expressed 14, intercellular bridge forming factor" "GO:0000776,GO:0000777,GO:0004672,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0007094,GO:0007140,GO:0008608,GO:0019901,GO:0030496,GO:0032091,GO:0032466,GO:0043063,GO:0045171,GO:0051301,GO:0051306,GO:0070062,GO:1990830" kinetochore|condensed chromosome kinetochore|protein kinase activity|protein binding|ATP binding|cytoplasm|protein phosphorylation|mitotic spindle assembly checkpoint|male meiotic nuclear division|attachment of spindle microtubules to kinetochore|protein kinase binding|midbody|negative regulation of protein binding|negative regulation of cytokinesis|intercellular bridge organization|intercellular bridge|cell division|mitotic sister chromatid separation|extracellular exosome|cellular response to leukemia inhibitory factor TEX15 8.164795208 12.48496659 3.844623824 0.307940257 -1.699277611 0.194385442 1 0.058060275 0.017579914 56154 "testis expressed 15, meiosis and synapsis associated" "GO:0005634,GO:0005737,GO:0006281,GO:0006306,GO:0007129,GO:0007140,GO:0007283,GO:0010529,GO:0010569,GO:0030154,GO:1990511" nucleus|cytoplasm|DNA repair|DNA methylation|homologous chromosome pairing at meiosis|male meiotic nuclear division|spermatogenesis|negative regulation of transposition|regulation of double-strand break repair via homologous recombination|cell differentiation|piRNA biosynthetic process TEX19 25.69834578 31.21241648 20.18427508 0.64667454 -0.628888283 0.428229942 1 0.784990246 0.499138652 400629 testis expressed 19 "GO:0001890,GO:0005515,GO:0005634,GO:0005737,GO:0007131,GO:0007140,GO:0007283,GO:0008584,GO:0010529,GO:0030154,GO:0034584" placenta development|protein binding|nucleus|cytoplasm|reciprocal meiotic recombination|male meiotic nuclear division|spermatogenesis|male gonad development|negative regulation of transposition|cell differentiation|piRNA binding TEX2 1337.702837 1356.699703 1318.705972 0.971995475 -0.040978498 0.86747196 1 5.526644503 5.28198242 55852 testis expressed 2 "GO:0003674,GO:0005783,GO:0005789,GO:0006665,GO:0006869,GO:0007165,GO:0008289,GO:0016021,GO:0031965" molecular_function|endoplasmic reticulum|endoplasmic reticulum membrane|sphingolipid metabolic process|lipid transport|signal transduction|lipid binding|integral component of membrane|nuclear membrane TEX22 5.003924597 5.202069413 4.80577978 0.923820772 -0.11431511 1 1 0.097583439 0.088641076 647310 testis expressed 22 GO:0001669 acrosomal vesicle TEX261 1835.286671 1790.552292 1880.02105 1.049967129 0.070344163 0.768362152 1 28.3977667 29.31777912 113419 testis expressed 261 "GO:0006888,GO:0006897,GO:0030134,GO:0030173,GO:0030176,GO:0097020" endoplasmic reticulum to Golgi vesicle-mediated transport|endocytosis|COPII-coated ER to Golgi transport vesicle|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|COPII receptor activity TEX264 559.5381495 533.7323218 585.3439772 1.096699513 0.133168292 0.621396557 1 11.85858162 12.78767459 51368 "testis expressed 264, ER-phagy receptor" "GO:0000421,GO:0002576,GO:0005515,GO:0005576,GO:0005634,GO:0005657,GO:0005789,GO:0005829,GO:0016021,GO:0031093,GO:0038023,GO:0061709,GO:0106300" autophagosome membrane|platelet degranulation|protein binding|extracellular region|nucleus|replication fork|endoplasmic reticulum membrane|cytosol|integral component of membrane|platelet alpha granule lumen|signaling receptor activity|reticulophagy|protein-DNA covalent cross-linking repair TEX29 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.022068751 0.060139236 121793 testis expressed 29 "GO:0005515,GO:0016021" protein binding|integral component of membrane TEX30 428.6831597 378.7106533 478.6556661 1.263908638 0.337892182 0.234592408 1 6.902695193 8.578385463 93081 testis expressed 30 GO:0016787 hydrolase activity TEX45 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.098565047 0.089532732 374877 testis expressed 45 GO:0005515 protein binding TEX46 2.601034707 5.202069413 0 0 #NAME? 0.147074026 1 0.542236101 0 729059 testis expressed 46 TEX48 4.003139677 4.161655531 3.844623824 0.923820772 -0.11431511 1 1 0.266306843 0.241902985 100505478 testis expressed 48 GO:0005515 protein binding TEX9 81.54415644 84.27352449 78.81478839 0.935225966 -0.096613108 0.871085485 1 1.101524152 1.012935423 374618 testis expressed 9 GO:0005515 protein binding TF 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.005232035 0.007128872 7018 transferrin "GO:0001895,GO:0002576,GO:0005515,GO:0005576,GO:0005615,GO:0005769,GO:0005770,GO:0005788,GO:0005886,GO:0005905,GO:0006826,GO:0006879,GO:0007015,GO:0007257,GO:0008198,GO:0008199,GO:0009925,GO:0009986,GO:0010008,GO:0016324,GO:0019731,GO:0030139,GO:0030316,GO:0030665,GO:0031232,GO:0031410,GO:0031647,GO:0031982,GO:0033572,GO:0034756,GO:0034774,GO:0034986,GO:0043687,GO:0044267,GO:0045178,GO:0045780,GO:0045893,GO:0048260,GO:0048471,GO:0055037,GO:0055072,GO:0060395,GO:0061024,GO:0070062,GO:0070371,GO:0071281,GO:0072562,GO:1990459,GO:1990712,GO:2000147" "retina homeostasis|platelet degranulation|protein binding|extracellular region|extracellular space|early endosome|late endosome|endoplasmic reticulum lumen|plasma membrane|clathrin-coated pit|iron ion transport|cellular iron ion homeostasis|actin filament organization|activation of JUN kinase activity|ferrous iron binding|ferric iron binding|basal plasma membrane|cell surface|endosome membrane|apical plasma membrane|antibacterial humoral response|endocytic vesicle|osteoclast differentiation|clathrin-coated vesicle membrane|extrinsic component of external side of plasma membrane|cytoplasmic vesicle|regulation of protein stability|vesicle|transferrin transport|regulation of iron ion transport|secretory granule lumen|iron chaperone activity|post-translational protein modification|cellular protein metabolic process|basal part of cell|positive regulation of bone resorption|positive regulation of transcription, DNA-templated|positive regulation of receptor-mediated endocytosis|perinuclear region of cytoplasm|recycling endosome|iron ion homeostasis|SMAD protein signal transduction|membrane organization|extracellular exosome|ERK1 and ERK2 cascade|cellular response to iron ion|blood microparticle|transferrin receptor binding|HFE-transferrin receptor complex|positive regulation of cell motility" "hsa04066,hsa04216,hsa04978" HIF-1 signaling pathway|Ferroptosis|Mineral absorption TF family TFAM 1389.208355 1447.215711 1331.200999 0.919835923 -0.120551554 0.616453009 1 15.3671394 13.89871264 7019 "transcription factor A, mitochondrial" "GO:0000976,GO:0001018,GO:0001223,GO:0003682,GO:0003700,GO:0003723,GO:0005515,GO:0005634,GO:0005739,GO:0005759,GO:0005829,GO:0006390,GO:0006391,GO:0007005,GO:0008301,GO:0031072,GO:0032991,GO:0033108,GO:0034246,GO:0042645,GO:0043565,GO:0045893" "transcription regulatory region sequence-specific DNA binding|mitochondrial promoter sequence-specific DNA binding|transcription coactivator binding|chromatin binding|DNA-binding transcription factor activity|RNA binding|protein binding|nucleus|mitochondrion|mitochondrial matrix|cytosol|mitochondrial transcription|transcription initiation from mitochondrial promoter|mitochondrion organization|DNA binding, bending|heat shock protein binding|protein-containing complex|mitochondrial respiratory chain complex assembly|mitochondrial transcription factor activity|mitochondrial nucleoid|sequence-specific DNA binding|positive regulation of transcription, DNA-templated" "hsa04371,hsa05016" Apelin signaling pathway|Huntington disease TFAP2A 923.0413417 866.6647642 979.4179192 1.13010008 0.176450541 0.477742318 1 10.32417536 11.47211407 7020 transcription factor AP-2 alpha "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0001822,GO:0003404,GO:0003409,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007605,GO:0008285,GO:0010628,GO:0010842,GO:0010944,GO:0021559,GO:0021623,GO:0030501,GO:0035115,GO:0042127,GO:0042472,GO:0042802,GO:0043066,GO:0043525,GO:0043565,GO:0045595,GO:0045892,GO:0045893,GO:0045944,GO:0048701,GO:0048856,GO:0060021,GO:0060349,GO:0061029,GO:0070172,GO:0071281,GO:1990837,GO:2000378" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|kidney development|optic vesicle morphogenesis|optic cup structural organization|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|sensory perception of sound|negative regulation of cell population proliferation|positive regulation of gene expression|retina layer formation|negative regulation of transcription by competitive promoter binding|trigeminal nerve development|oculomotor nerve formation|positive regulation of bone mineralization|embryonic forelimb morphogenesis|regulation of cell population proliferation|inner ear morphogenesis|identical protein binding|negative regulation of apoptotic process|positive regulation of neuron apoptotic process|sequence-specific DNA binding|regulation of cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|embryonic cranial skeleton morphogenesis|anatomical structure development|roof of mouth development|bone morphogenesis|eyelid development in camera-type eye|positive regulation of tooth mineralization|cellular response to iron ion|sequence-specific double-stranded DNA binding|negative regulation of reactive oxygen species metabolic process" AP_2 TFAP2C 561.2371645 590.9550853 531.5192437 0.899424096 -0.152926559 0.569276494 1 11.019632 9.745469992 7022 transcription factor AP-2 gamma "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006357,GO:0007267,GO:0008584,GO:0040029,GO:0042127,GO:0045944,GO:0048856,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|regulation of transcription by RNA polymerase II|cell-cell signaling|male gonad development|regulation of gene expression, epigenetic|regulation of cell population proliferation|positive regulation of transcription by RNA polymerase II|anatomical structure development|sequence-specific double-stranded DNA binding" AP_2 TFAP2E 14.61045374 17.687036 11.53387147 0.65210878 -0.61681545 0.556527256 1 0.133266215 0.085449847 339488 transcription factor AP-2 epsilon "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0005634,GO:0006357,GO:0042127,GO:0045944,GO:0048856,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|regulation of cell population proliferation|positive regulation of transcription by RNA polymerase II|anatomical structure development|sequence-specific double-stranded DNA binding" TFAP4 214.9951505 256.982229 173.0080721 0.673229712 -0.570829245 0.106243141 1 4.896347465 3.241206364 7023 transcription factor AP-4 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006357,GO:0006978,GO:0008285,GO:0017053,GO:0042803,GO:0042826,GO:0043065,GO:0043392,GO:0043565,GO:0043922,GO:0043923,GO:0045736,GO:0045892,GO:0045893,GO:0045944,GO:0065003,GO:0070888,GO:0071157,GO:0071549,GO:1901990,GO:1990837,GO:2001269" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of cell population proliferation|transcription repressor complex|protein homodimerization activity|histone deacetylase binding|positive regulation of apoptotic process|negative regulation of DNA binding|sequence-specific DNA binding|negative regulation by host of viral transcription|positive regulation by host of viral transcription|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein-containing complex assembly|E-box binding|negative regulation of cell cycle arrest|cellular response to dexamethasone stimulus|regulation of mitotic cell cycle phase transition|sequence-specific double-stranded DNA binding|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway" hsa05205 Proteoglycans in cancer bHLH TFB1M 516.3358213 509.8028025 522.8688401 1.025629591 0.036509792 0.900220531 1 3.97650374 4.010173073 51106 "transcription factor B1, mitochondrial" "GO:0000154,GO:0000179,GO:0003677,GO:0003723,GO:0005515,GO:0005759,GO:0006391,GO:0007005,GO:0031167,GO:0034246,GO:0042645" "rRNA modification|rRNA (adenine-N6,N6-)-dimethyltransferase activity|DNA binding|RNA binding|protein binding|mitochondrial matrix|transcription initiation from mitochondrial promoter|mitochondrion organization|rRNA methylation|mitochondrial transcription factor activity|mitochondrial nucleoid" TFB2M 311.016397 292.356301 329.6764929 1.127653113 0.173323336 0.583028466 1 9.039697832 10.02306658 64216 "transcription factor B2, mitochondrial" "GO:0000179,GO:0003712,GO:0003723,GO:0005739,GO:0005759,GO:0006355,GO:0006390,GO:0006391,GO:0007005,GO:0031167,GO:0034246,GO:0042645" "rRNA (adenine-N6,N6-)-dimethyltransferase activity|transcription coregulator activity|RNA binding|mitochondrion|mitochondrial matrix|regulation of transcription, DNA-templated|mitochondrial transcription|transcription initiation from mitochondrial promoter|mitochondrion organization|rRNA methylation|mitochondrial transcription factor activity|mitochondrial nucleoid" TFCP2 725.8760374 787.5933092 664.1587656 0.843276292 -0.2459227 0.335313265 1 11.04082148 9.154665012 7024 transcription factor CP2 "GO:0000785,GO:0000978,GO:0000981,GO:0000987,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0008134,GO:0032991,GO:0042789,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription factor binding|protein-containing complex|mRNA transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" TFCP2L1 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.005432441 0.014803866 29842 transcription factor CP2 like 1 "GO:0000122,GO:0000785,GO:0000902,GO:0000978,GO:0000981,GO:0001228,GO:0002070,GO:0005634,GO:0005737,GO:0006357,GO:0007028,GO:0007431,GO:0008340,GO:0016020,GO:0045927,GO:0045944,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|cell morphogenesis|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|epithelial cell maturation|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|cytoplasm organization|salivary gland development|determination of adult lifespan|membrane|positive regulation of growth|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" TFDP1 2736.900148 2662.419126 2811.381171 1.055949886 0.078541367 0.740882722 1 46.73961034 48.52880235 7027 transcription factor Dp-1 "GO:0000083,GO:0000785,GO:0000977,GO:0000981,GO:0000987,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006357,GO:0006366,GO:0006977,GO:0008134,GO:0008544,GO:0019904,GO:0043276,GO:0045944,GO:0051091,GO:0070317,GO:0070345,GO:0090575,GO:1900087,GO:1900740,GO:2000278" "regulation of transcription involved in G1/S transition of mitotic cell cycle|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|transcription factor binding|epidermis development|protein domain specific binding|anoikis|positive regulation of transcription by RNA polymerase II|positive regulation of DNA-binding transcription factor activity|negative regulation of G0 to G1 transition|negative regulation of fat cell proliferation|RNA polymerase II transcription regulator complex|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|regulation of DNA biosynthetic process" "hsa04110,hsa04350" Cell cycle|TGF-beta signaling pathway E2F TFDP2 1637.30425 1652.177246 1622.431254 0.981995883 -0.026211118 0.91483118 1 8.432022858 8.141653605 7029 transcription factor Dp-2 "GO:0000083,GO:0000785,GO:0000977,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006357,GO:0006977,GO:0007507,GO:0008134,GO:0019904,GO:0045892,GO:0045944,GO:0070317,GO:0072686,GO:0090575,GO:1900740" "regulation of transcription involved in G1/S transition of mitotic cell cycle|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|heart development|transcription factor binding|protein domain specific binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of G0 to G1 transition|mitotic spindle|RNA polymerase II transcription regulator complex|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" hsa04110 Cell cycle TFE3 3914.339619 3697.630939 4131.048299 1.117214878 0.159906691 0.501920924 1 60.92490499 66.92721445 7030 transcription factor binding to IGHM enhancer 3 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0002250,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006959,GO:0045670,GO:0045785,GO:0045893,GO:0045944,GO:0046983,GO:0090336,GO:0120163,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|adaptive immune response|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|humoral immune response|regulation of osteoclast differentiation|positive regulation of cell adhesion|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|positive regulation of brown fat cell differentiation|negative regulation of cold-induced thermogenesis|sequence-specific double-stranded DNA binding" "hsa04137,hsa05202,hsa05211" Mitophagy - animal|Transcriptional misregulation in cancer|Renal cell carcinoma bHLH TFEB 74.61791993 79.07145508 70.16438479 0.887354162 -0.172418064 0.759980648 1 1.227071309 1.070626456 7942 transcription factor EB "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001892,GO:0002250,GO:0003700,GO:0005515,GO:0005634,GO:0005737,GO:0005765,GO:0005829,GO:0006355,GO:0006357,GO:0006914,GO:0006959,GO:0007040,GO:0009267,GO:0010468,GO:0010508,GO:0019899,GO:0032418,GO:0034198,GO:0045893,GO:0045944,GO:0046983,GO:1990837" "chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|embryonic placenta development|adaptive immune response|DNA-binding transcription factor activity|protein binding|nucleus|cytoplasm|lysosomal membrane|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|autophagy|humoral immune response|lysosome organization|cellular response to starvation|regulation of gene expression|positive regulation of autophagy|enzyme binding|lysosome localization|cellular response to amino acid starvation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|protein dimerization activity|sequence-specific double-stranded DNA binding" hsa04137 Mitophagy - animal TFEC 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.014124899 0.019245779 22797 transcription factor EC "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0034605,GO:0045944,GO:0046983,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cellular response to heat|positive regulation of transcription by RNA polymerase II|protein dimerization activity|sequence-specific double-stranded DNA binding" TFG 3292.202415 3173.262342 3411.142488 1.074963908 0.104288222 0.660668889 1 71.94187722 76.0408263 10342 trafficking from ER to golgi regulator "GO:0000139,GO:0005515,GO:0005737,GO:0005829,GO:0006888,GO:0042802,GO:0043123,GO:0043231,GO:0048208,GO:0070971" Golgi membrane|protein binding|cytoplasm|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|COPII vesicle coating|endoplasmic reticulum exit site "hsa05200,hsa05216" Pathways in cancer|Thyroid cancer TFIP11 810.3734732 797.997448 822.7494983 1.031017706 0.044069109 0.865478585 1 7.035793349 7.132641193 24144 tuftelin interacting protein 11 "GO:0000390,GO:0000398,GO:0000781,GO:0003676,GO:0005515,GO:0005654,GO:0005681,GO:0005730,GO:0005737,GO:0006396,GO:0016607,GO:0031012,GO:0031214,GO:0031333,GO:0031848,GO:0032091,GO:0071008,GO:0071013,GO:1904876,GO:2001033" "spliceosomal complex disassembly|mRNA splicing, via spliceosome|chromosome, telomeric region|nucleic acid binding|protein binding|nucleoplasm|spliceosomal complex|nucleolus|cytoplasm|RNA processing|nuclear speck|extracellular matrix|biomineral tissue development|negative regulation of protein-containing complex assembly|protection from non-homologous end joining at telomere|negative regulation of protein binding|U2-type post-mRNA release spliceosomal complex|catalytic step 2 spliceosome|negative regulation of DNA ligase activity|negative regulation of double-strand break repair via nonhomologous end joining" TFPI 3317.147196 3285.627041 3348.667351 1.019186691 0.027418343 0.909196745 1 33.70778094 33.77964531 7035 tissue factor pathway inhibitor "GO:0004866,GO:0004867,GO:0005576,GO:0005615,GO:0005783,GO:0005886,GO:0005901,GO:0007596,GO:0007598,GO:0009986,GO:0010951,GO:0030195,GO:0031090,GO:0031225,GO:0032355,GO:0071222,GO:0071347,GO:0071383" "endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|endoplasmic reticulum|plasma membrane|caveola|blood coagulation|blood coagulation, extrinsic pathway|cell surface|negative regulation of endopeptidase activity|negative regulation of blood coagulation|organelle membrane|anchored component of membrane|response to estradiol|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to steroid hormone stimulus" hsa04610 Complement and coagulation cascades TFPI2 14205.58605 11675.52459 16735.64751 1.433395765 0.519436997 0.046870291 1 282.3295373 397.9180246 7980 tissue factor pathway inhibitor 2 "GO:0004867,GO:0005201,GO:0005615,GO:0007596,GO:0010951,GO:0031012" serine-type endopeptidase inhibitor activity|extracellular matrix structural constituent|extracellular space|blood coagulation|negative regulation of endopeptidase activity|extracellular matrix TFPT 519.7545873 473.3883166 566.1208581 1.195891065 0.258085979 0.342067129 1 20.72507334 24.37018779 29844 TCF3 fusion partner "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006281,GO:0006310,GO:0016579,GO:0031011,GO:0043065,GO:0097190" DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|DNA repair|DNA recombination|protein deubiquitination|Ino80 complex|positive regulation of apoptotic process|apoptotic signaling pathway TFRC 3228.58184 3332.445666 3124.718013 0.937665104 -0.092855352 0.695939528 1 24.15736219 22.2724731 7037 transferrin receptor "GO:0001558,GO:0001618,GO:0001934,GO:0003723,GO:0003725,GO:0004998,GO:0005515,GO:0005576,GO:0005615,GO:0005768,GO:0005769,GO:0005886,GO:0005887,GO:0005905,GO:0006826,GO:0006879,GO:0009897,GO:0009986,GO:0010008,GO:0010628,GO:0010637,GO:0016020,GO:0016323,GO:0019901,GO:0030316,GO:0030665,GO:0030890,GO:0031334,GO:0031410,GO:0031623,GO:0033138,GO:0033572,GO:0035556,GO:0035690,GO:0042102,GO:0042127,GO:0042470,GO:0042802,GO:0042803,GO:0043066,GO:0043123,GO:0043231,GO:0044877,GO:0045780,GO:0045830,GO:0046718,GO:0048471,GO:0051092,GO:0055037,GO:0061024,GO:0070062,GO:0072562,GO:0150104,GO:1900182,GO:1903561,GO:1990712,GO:1990830" regulation of cell growth|virus receptor activity|positive regulation of protein phosphorylation|RNA binding|double-stranded RNA binding|transferrin receptor activity|protein binding|extracellular region|extracellular space|endosome|early endosome|plasma membrane|integral component of plasma membrane|clathrin-coated pit|iron ion transport|cellular iron ion homeostasis|external side of plasma membrane|cell surface|endosome membrane|positive regulation of gene expression|negative regulation of mitochondrial fusion|membrane|basolateral plasma membrane|protein kinase binding|osteoclast differentiation|clathrin-coated vesicle membrane|positive regulation of B cell proliferation|positive regulation of protein-containing complex assembly|cytoplasmic vesicle|receptor internalization|positive regulation of peptidyl-serine phosphorylation|transferrin transport|intracellular signal transduction|cellular response to drug|positive regulation of T cell proliferation|regulation of cell population proliferation|melanosome|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|protein-containing complex binding|positive regulation of bone resorption|positive regulation of isotype switching|viral entry into host cell|perinuclear region of cytoplasm|positive regulation of NF-kappaB transcription factor activity|recycling endosome|membrane organization|extracellular exosome|blood microparticle|transport across blood-brain barrier|positive regulation of protein localization to nucleus|extracellular vesicle|HFE-transferrin receptor complex|cellular response to leukemia inhibitory factor "hsa04066,hsa04144,hsa04145,hsa04216,hsa04640" HIF-1 signaling pathway|Endocytosis|Phagosome|Ferroptosis|Hematopoietic cell lineage TGDS 409.6581854 383.9127227 435.4036481 1.134121435 0.181575124 0.531282539 1 10.27003329 11.45256034 23483 "TDP-glucose 4,6-dehydratase" "GO:0005515,GO:0008460,GO:0009225" "protein binding|dTDP-glucose 4,6-dehydratase activity|nucleotide-sugar metabolic process" TGFA 1451.422409 1200.637621 1702.207198 1.417752675 0.503605878 0.035290535 0.95006405 14.62918336 20.3934986 7039 transforming growth factor alpha "GO:0000139,GO:0000165,GO:0000187,GO:0005154,GO:0005515,GO:0005576,GO:0005615,GO:0005789,GO:0005886,GO:0006357,GO:0006888,GO:0007165,GO:0007173,GO:0008083,GO:0008284,GO:0009986,GO:0012507,GO:0016021,GO:0016323,GO:0030665,GO:0031410,GO:0033116,GO:0035556,GO:0042059,GO:0045741,GO:0045840,GO:0048208,GO:0048471,GO:0050679,GO:0051781,GO:0051897,GO:0061024" Golgi membrane|MAPK cascade|activation of MAPK activity|epidermal growth factor receptor binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum membrane|plasma membrane|regulation of transcription by RNA polymerase II|endoplasmic reticulum to Golgi vesicle-mediated transport|signal transduction|epidermal growth factor receptor signaling pathway|growth factor activity|positive regulation of cell population proliferation|cell surface|ER to Golgi transport vesicle membrane|integral component of membrane|basolateral plasma membrane|clathrin-coated vesicle membrane|cytoplasmic vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|intracellular signal transduction|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of epidermal growth factor-activated receptor activity|positive regulation of mitotic nuclear division|COPII vesicle coating|perinuclear region of cytoplasm|positive regulation of epithelial cell proliferation|positive regulation of cell division|positive regulation of protein kinase B signaling|membrane organization "hsa01521,hsa04010,hsa04012,hsa04014,hsa04151,hsa04915,hsa05200,hsa05210,hsa05211,hsa05212,hsa05214,hsa05215,hsa05223,hsa05225" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|PI3K-Akt signaling pathway|Estrogen signaling pathway|Pathways in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Glioma|Prostate cancer|Non-small cell lung cancer|Hepatocellular carcinoma TGFB1 1842.118558 1831.128433 1853.108683 1.012003664 0.017214513 0.944535508 1 46.46883453 46.23970381 7040 transforming growth factor beta 1 "GO:0000165,GO:0001570,GO:0001837,GO:0001843,GO:0001933,GO:0001934,GO:0002062,GO:0002244,GO:0002248,GO:0002576,GO:0003179,GO:0003180,GO:0003823,GO:0005114,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005796,GO:0005886,GO:0005902,GO:0006468,GO:0006611,GO:0006754,GO:0006796,GO:0006954,GO:0007050,GO:0007173,GO:0007179,GO:0007182,GO:0007183,GO:0007435,GO:0007507,GO:0008083,GO:0008284,GO:0008285,GO:0009611,GO:0009986,GO:0010575,GO:0010628,GO:0010629,GO:0010716,GO:0010718,GO:0010742,GO:0010763,GO:0010800,GO:0010862,GO:0010936,GO:0014008,GO:0016202,GO:0016477,GO:0017015,GO:0019221,GO:0019899,GO:0021915,GO:0022408,GO:0030214,GO:0030308,GO:0030334,GO:0030335,GO:0030501,GO:0030509,GO:0030512,GO:0031012,GO:0031093,GO:0031293,GO:0031334,GO:0031663,GO:0032270,GO:0032355,GO:0032570,GO:0032740,GO:0032801,GO:0032930,GO:0032967,GO:0033138,GO:0034713,GO:0034714,GO:0035307,GO:0042127,GO:0042306,GO:0042307,GO:0042802,GO:0043117,GO:0043406,GO:0043491,GO:0043536,GO:0043537,GO:0043552,GO:0043932,GO:0045216,GO:0045596,GO:0045599,GO:0045662,GO:0045786,GO:0045892,GO:0045893,GO:0045918,GO:0045930,GO:0045944,GO:0048298,GO:0048535,GO:0048642,GO:0050680,GO:0050714,GO:0050731,GO:0050900,GO:0050921,GO:0051098,GO:0051101,GO:0051781,GO:0051897,GO:0055010,GO:0060312,GO:0060389,GO:0060390,GO:0060391,GO:0060395,GO:0060965,GO:0062023,GO:0070168,GO:0070374,GO:0070723,GO:0071407,GO:0071560,GO:0072562,GO:0085029,GO:0090263,GO:0097191,GO:1900126,GO:1900182,GO:1901203,GO:1901666,GO:1902893,GO:1902895,GO:1903077,GO:1903799,GO:1903800,GO:1905005,GO:1905313,GO:1990402,GO:2000679,GO:2000727" "MAPK cascade|vasculogenesis|epithelial to mesenchymal transition|neural tube closure|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|chondrocyte differentiation|hematopoietic progenitor cell differentiation|connective tissue replacement involved in inflammatory response wound healing|platelet degranulation|heart valve morphogenesis|aortic valve morphogenesis|antigen binding|type II transforming growth factor beta receptor binding|cytokine activity|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|Golgi lumen|plasma membrane|microvillus|protein phosphorylation|protein export from nucleus|ATP biosynthetic process|phosphate-containing compound metabolic process|inflammatory response|cell cycle arrest|epidermal growth factor receptor signaling pathway|transforming growth factor beta receptor signaling pathway|common-partner SMAD protein phosphorylation|SMAD protein complex assembly|salivary gland morphogenesis|heart development|growth factor activity|positive regulation of cell population proliferation|negative regulation of cell population proliferation|response to wounding|cell surface|positive regulation of vascular endothelial growth factor production|positive regulation of gene expression|negative regulation of gene expression|negative regulation of extracellular matrix disassembly|positive regulation of epithelial to mesenchymal transition|macrophage derived foam cell differentiation|positive regulation of fibroblast migration|positive regulation of peptidyl-threonine phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of macrophage cytokine production|positive regulation of microglia differentiation|regulation of striated muscle tissue development|cell migration|regulation of transforming growth factor beta receptor signaling pathway|cytokine-mediated signaling pathway|enzyme binding|neural tube development|negative regulation of cell-cell adhesion|hyaluronan catabolic process|negative regulation of cell growth|regulation of cell migration|positive regulation of cell migration|positive regulation of bone mineralization|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|extracellular matrix|platelet alpha granule lumen|membrane protein intracellular domain proteolysis|positive regulation of protein-containing complex assembly|lipopolysaccharide-mediated signaling pathway|positive regulation of cellular protein metabolic process|response to estradiol|response to progesterone|positive regulation of interleukin-17 production|receptor catabolic process|positive regulation of superoxide anion generation|positive regulation of collagen biosynthetic process|positive regulation of peptidyl-serine phosphorylation|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding|positive regulation of protein dephosphorylation|regulation of cell population proliferation|regulation of protein import into nucleus|positive regulation of protein import into nucleus|identical protein binding|positive regulation of vascular permeability|positive regulation of MAP kinase activity|protein kinase B signaling|positive regulation of blood vessel endothelial cell migration|negative regulation of blood vessel endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase activity|ossification involved in bone remodeling|cell-cell junction organization|negative regulation of cell differentiation|negative regulation of fat cell differentiation|negative regulation of myoblast differentiation|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of cytolysis|negative regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|positive regulation of isotype switching to IgA isotypes|lymph node development|negative regulation of skeletal muscle tissue development|negative regulation of epithelial cell proliferation|positive regulation of protein secretion|positive regulation of peptidyl-tyrosine phosphorylation|leukocyte migration|positive regulation of chemotaxis|regulation of binding|regulation of DNA binding|positive regulation of cell division|positive regulation of protein kinase B signaling|ventricular cardiac muscle tissue morphogenesis|regulation of blood vessel remodeling|pathway-restricted SMAD protein phosphorylation|regulation of SMAD protein signal transduction|positive regulation of SMAD protein signal transduction|SMAD protein signal transduction|negative regulation of gene silencing by miRNA|collagen-containing extracellular matrix|negative regulation of biomineral tissue development|positive regulation of ERK1 and ERK2 cascade|response to cholesterol|cellular response to organic cyclic compound|cellular response to transforming growth factor beta stimulus|blood microparticle|extracellular matrix assembly|positive regulation of canonical Wnt signaling pathway|extrinsic apoptotic signaling pathway|negative regulation of hyaluronan biosynthetic process|positive regulation of protein localization to nucleus|positive regulation of extracellular matrix assembly|positive regulation of NAD+ ADP-ribosyltransferase activity|regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of protein localization to plasma membrane|negative regulation of production of miRNAs involved in gene silencing by miRNA|positive regulation of production of miRNAs involved in gene silencing by miRNA|regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|transforming growth factor beta receptor signaling pathway involved in heart development|embryonic liver development|positive regulation of transcription regulatory region DNA binding|positive regulation of cardiac muscle cell differentiation" "hsa04010,hsa04060,hsa04068,hsa04110,hsa04218,hsa04350,hsa04380,hsa04390,hsa04659,hsa04672,hsa04926,hsa04932,hsa04933,hsa05140,hsa05142,hsa05144,hsa05145,hsa05146,hsa05152,hsa05161,hsa05166,hsa05200,hsa05205,hsa05210,hsa05211,hsa05212,hsa05220,hsa05225,hsa05226,hsa05321,hsa05323,hsa05410,hsa05414" MAPK signaling pathway|Cytokine-cytokine receptor interaction|FoxO signaling pathway|Cell cycle|Cellular senescence|TGF-beta signaling pathway|Osteoclast differentiation|Hippo signaling pathway|Th17 cell differentiation|Intestinal immune network for IgA production|Relaxin signaling pathway|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Leishmaniasis|Chagas disease|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer|Inflammatory bowel disease|Rheumatoid arthritis|Hypertrophic cardiomyopathy|Dilated cardiomyopathy TGFB1I1 1297.667024 1226.647968 1368.686081 1.115793706 0.158070318 0.512544734 1 33.67487014 36.94545465 7041 transforming growth factor beta 1 induced transcript 1 "GO:0003712,GO:0003713,GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0007155,GO:0008285,GO:0009408,GO:0010718,GO:0016055,GO:0016331,GO:0016363,GO:0030511,GO:0030512,GO:0030579,GO:0030855,GO:0045165,GO:0045599,GO:0045893,GO:0046872,GO:0048495,GO:0050681,GO:0062023,GO:0070411" "transcription coregulator activity|transcription coactivator activity|protein binding|cytosol|cytoskeleton|plasma membrane|focal adhesion|cell adhesion|negative regulation of cell population proliferation|response to heat|positive regulation of epithelial to mesenchymal transition|Wnt signaling pathway|morphogenesis of embryonic epithelium|nuclear matrix|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process|epithelial cell differentiation|cell fate commitment|negative regulation of fat cell differentiation|positive regulation of transcription, DNA-templated|metal ion binding|Roundabout binding|androgen receptor binding|collagen-containing extracellular matrix|I-SMAD binding" TGFB2 44.03453645 45.77821084 42.29086206 0.923820772 -0.11431511 0.89133833 1 0.410466898 0.372852484 7042 transforming growth factor beta 2 "GO:0000902,GO:0001501,GO:0001540,GO:0001654,GO:0001666,GO:0001822,GO:0001837,GO:0001843,GO:0001942,GO:0002576,GO:0003007,GO:0003148,GO:0003149,GO:0003179,GO:0003181,GO:0003184,GO:0003203,GO:0003215,GO:0003222,GO:0003274,GO:0003289,GO:0003407,GO:0005102,GO:0005114,GO:0005125,GO:0005160,GO:0005515,GO:0005576,GO:0005615,GO:0006468,GO:0007050,GO:0007179,GO:0007435,GO:0007507,GO:0008083,GO:0008219,GO:0008284,GO:0008285,GO:0008347,GO:0008584,GO:0009611,GO:0009792,GO:0010002,GO:0010629,GO:0010634,GO:0010693,GO:0010718,GO:0010862,GO:0010936,GO:0014068,GO:0016477,GO:0016525,GO:0030097,GO:0030199,GO:0030307,GO:0030308,GO:0030326,GO:0030424,GO:0030509,GO:0030593,GO:0031069,GO:0031093,GO:0032147,GO:0032570,GO:0032874,GO:0032909,GO:0033630,GO:0034714,GO:0035910,GO:0042060,GO:0042127,GO:0042416,GO:0042476,GO:0042493,GO:0042704,GO:0042803,GO:0043025,GO:0043525,GO:0045216,GO:0045726,GO:0045747,GO:0045778,GO:0045787,GO:0045823,GO:0046580,GO:0048103,GO:0048566,GO:0048666,GO:0048699,GO:0048839,GO:0050680,GO:0050714,GO:0050778,GO:0051781,GO:0051794,GO:0051795,GO:0051891,GO:0060038,GO:0060065,GO:0060317,GO:0060389,GO:0060395,GO:0060412,GO:0060413,GO:0061626,GO:0062009,GO:0062023,GO:0097191,GO:1902256,GO:1902895,GO:1903659,GO:1903701,GO:1904888,GO:1905006,GO:1905007" cell morphogenesis|skeletal system development|amyloid-beta binding|eye development|response to hypoxia|kidney development|epithelial to mesenchymal transition|neural tube closure|hair follicle development|platelet degranulation|heart morphogenesis|outflow tract septum morphogenesis|membranous septum morphogenesis|heart valve morphogenesis|atrioventricular valve morphogenesis|pulmonary valve morphogenesis|endocardial cushion morphogenesis|cardiac right ventricle morphogenesis|ventricular trabecula myocardium morphogenesis|endocardial cushion fusion|atrial septum primum morphogenesis|neural retina development|signaling receptor binding|type II transforming growth factor beta receptor binding|cytokine activity|transforming growth factor beta receptor binding|protein binding|extracellular region|extracellular space|protein phosphorylation|cell cycle arrest|transforming growth factor beta receptor signaling pathway|salivary gland morphogenesis|heart development|growth factor activity|cell death|positive regulation of cell population proliferation|negative regulation of cell population proliferation|glial cell migration|male gonad development|response to wounding|embryo development ending in birth or egg hatching|cardioblast differentiation|negative regulation of gene expression|positive regulation of epithelial cell migration|negative regulation of alkaline phosphatase activity|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of macrophage cytokine production|positive regulation of phosphatidylinositol 3-kinase signaling|cell migration|negative regulation of angiogenesis|hemopoiesis|collagen fibril organization|positive regulation of cell growth|negative regulation of cell growth|embryonic limb morphogenesis|axon|BMP signaling pathway|neutrophil chemotaxis|hair follicle morphogenesis|platelet alpha granule lumen|activation of protein kinase activity|response to progesterone|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor beta2 production|positive regulation of cell adhesion mediated by integrin|type III transforming growth factor beta receptor binding|ascending aorta morphogenesis|wound healing|regulation of cell population proliferation|dopamine biosynthetic process|odontogenesis|response to drug|uterine wall breakdown|protein homodimerization activity|neuronal cell body|positive regulation of neuron apoptotic process|cell-cell junction organization|positive regulation of integrin biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of ossification|positive regulation of cell cycle|positive regulation of heart contraction|negative regulation of Ras protein signal transduction|somatic stem cell division|embryonic digestive tract development|neuron development|generation of neurons|inner ear development|negative regulation of epithelial cell proliferation|positive regulation of protein secretion|positive regulation of immune response|positive regulation of cell division|regulation of timing of catagen|positive regulation of timing of catagen|positive regulation of cardioblast differentiation|cardiac muscle cell proliferation|uterus development|cardiac epithelial to mesenchymal transition|pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction|ventricular septum morphogenesis|atrial septum morphogenesis|pharyngeal arch artery morphogenesis|secondary palate development|collagen-containing extracellular matrix|extrinsic apoptotic signaling pathway|regulation of apoptotic process involved in outflow tract morphogenesis|positive regulation of pri-miRNA transcription by RNA polymerase II|regulation of complement-dependent cytotoxicity|substantia propria of cornea development|cranial skeletal system development|negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation "hsa04010,hsa04060,hsa04068,hsa04110,hsa04218,hsa04350,hsa04380,hsa04390,hsa04933,hsa05140,hsa05142,hsa05144,hsa05145,hsa05146,hsa05152,hsa05161,hsa05166,hsa05200,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05220,hsa05225,hsa05226,hsa05321,hsa05323,hsa05410,hsa05414" MAPK signaling pathway|Cytokine-cytokine receptor interaction|FoxO signaling pathway|Cell cycle|Cellular senescence|TGF-beta signaling pathway|Osteoclast differentiation|Hippo signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Leishmaniasis|Chagas disease|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer|Inflammatory bowel disease|Rheumatoid arthritis|Hypertrophic cardiomyopathy|Dilated cardiomyopathy TGFB3 33.98705829 34.33365813 33.64045846 0.979809909 -0.029426212 1 1 0.469225155 0.452058139 7043 transforming growth factor beta 3 "GO:0000187,GO:0001666,GO:0001701,GO:0002576,GO:0005114,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005886,GO:0007179,GO:0007435,GO:0007565,GO:0007568,GO:0008083,GO:0008284,GO:0008285,GO:0009986,GO:0010718,GO:0010862,GO:0010936,GO:0030315,GO:0030501,GO:0030509,GO:0030512,GO:0030879,GO:0031093,GO:0032570,GO:0032967,GO:0034616,GO:0034713,GO:0034714,GO:0042060,GO:0042127,GO:0042476,GO:0042704,GO:0042802,GO:0043025,GO:0043065,GO:0043231,GO:0043524,GO:0043627,GO:0043932,GO:0044877,GO:0045216,GO:0045893,GO:0045944,GO:0048286,GO:0048565,GO:0048702,GO:0048839,GO:0050431,GO:0050714,GO:0051491,GO:0051496,GO:0051781,GO:0060325,GO:0060364,GO:0060391,GO:0060395,GO:0062009,GO:0062023,GO:0070483,GO:1904706,GO:1905005,GO:1905075" "activation of MAPK activity|response to hypoxia|in utero embryonic development|platelet degranulation|type II transforming growth factor beta receptor binding|cytokine activity|protein binding|extracellular region|extracellular space|nucleus|plasma membrane|transforming growth factor beta receptor signaling pathway|salivary gland morphogenesis|female pregnancy|aging|growth factor activity|positive regulation of cell population proliferation|negative regulation of cell population proliferation|cell surface|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of macrophage cytokine production|T-tubule|positive regulation of bone mineralization|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|mammary gland development|platelet alpha granule lumen|response to progesterone|positive regulation of collagen biosynthetic process|response to laminar fluid shear stress|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding|wound healing|regulation of cell population proliferation|odontogenesis|uterine wall breakdown|identical protein binding|neuronal cell body|positive regulation of apoptotic process|intracellular membrane-bounded organelle|negative regulation of neuron apoptotic process|response to estrogen|ossification involved in bone remodeling|protein-containing complex binding|cell-cell junction organization|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|lung alveolus development|digestive tract development|embryonic neurocranium morphogenesis|inner ear development|transforming growth factor beta binding|positive regulation of protein secretion|positive regulation of filopodium assembly|positive regulation of stress fiber assembly|positive regulation of cell division|face morphogenesis|frontal suture morphogenesis|positive regulation of SMAD protein signal transduction|SMAD protein signal transduction|secondary palate development|collagen-containing extracellular matrix|detection of hypoxia|negative regulation of vascular associated smooth muscle cell proliferation|regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|positive regulation of tight junction disassembly" "hsa04010,hsa04060,hsa04068,hsa04110,hsa04218,hsa04350,hsa04390,hsa04933,hsa05140,hsa05142,hsa05144,hsa05145,hsa05146,hsa05152,hsa05161,hsa05166,hsa05200,hsa05210,hsa05211,hsa05212,hsa05220,hsa05225,hsa05226,hsa05321,hsa05323,hsa05410,hsa05414" MAPK signaling pathway|Cytokine-cytokine receptor interaction|FoxO signaling pathway|Cell cycle|Cellular senescence|TGF-beta signaling pathway|Hippo signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Leishmaniasis|Chagas disease|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer|Inflammatory bowel disease|Rheumatoid arthritis|Hypertrophic cardiomyopathy|Dilated cardiomyopathy TGFBI 689.6200673 718.9259929 660.3141418 0.918473039 -0.122690721 0.636118069 1 14.14740373 12.77657176 7045 transforming growth factor beta induced "GO:0001525,GO:0002062,GO:0005178,GO:0005201,GO:0005515,GO:0005518,GO:0005576,GO:0005604,GO:0005615,GO:0005802,GO:0005886,GO:0007155,GO:0007162,GO:0007601,GO:0008283,GO:0030198,GO:0031012,GO:0042802,GO:0044267,GO:0050839,GO:0050840,GO:0050896,GO:0062023,GO:0070062" angiogenesis|chondrocyte differentiation|integrin binding|extracellular matrix structural constituent|protein binding|collagen binding|extracellular region|basement membrane|extracellular space|trans-Golgi network|plasma membrane|cell adhesion|negative regulation of cell adhesion|visual perception|cell population proliferation|extracellular matrix organization|extracellular matrix|identical protein binding|cellular protein metabolic process|cell adhesion molecule binding|extracellular matrix binding|response to stimulus|collagen-containing extracellular matrix|extracellular exosome TGFBR1 334.4106181 376.6298255 292.1914106 0.775805289 -0.366233484 0.229299211 1 3.283783952 2.504946708 7046 transforming growth factor beta receptor 1 "GO:0000186,GO:0001501,GO:0001701,GO:0001822,GO:0001824,GO:0001837,GO:0001937,GO:0001938,GO:0002088,GO:0003222,GO:0003223,GO:0003342,GO:0004672,GO:0004674,GO:0005024,GO:0005025,GO:0005114,GO:0005515,GO:0005524,GO:0005634,GO:0005768,GO:0005886,GO:0005923,GO:0006355,GO:0006468,GO:0006915,GO:0007050,GO:0007165,GO:0007179,GO:0007399,GO:0007507,GO:0008284,GO:0008354,GO:0008584,GO:0009791,GO:0009952,GO:0009986,GO:0010628,GO:0010717,GO:0010718,GO:0010862,GO:0016361,GO:0016579,GO:0018105,GO:0018107,GO:0019838,GO:0030199,GO:0030307,GO:0030335,GO:0030512,GO:0031396,GO:0032331,GO:0032924,GO:0035556,GO:0042060,GO:0042118,GO:0043062,GO:0043235,GO:0043393,GO:0043542,GO:0045121,GO:0045893,GO:0046332,GO:0046872,GO:0048179,GO:0048185,GO:0048538,GO:0048663,GO:0048701,GO:0048705,GO:0048762,GO:0048844,GO:0048870,GO:0050431,GO:0051272,GO:0051491,GO:0051496,GO:0051897,GO:0060017,GO:0060021,GO:0060037,GO:0060043,GO:0060317,GO:0060389,GO:0060391,GO:0060412,GO:0060978,GO:0060982,GO:0070411,GO:0070723,GO:0071363,GO:0071560,GO:1905007,GO:1905075,GO:1905223,GO:2001235,GO:2001237" "activation of MAPKK activity|skeletal system development|in utero embryonic development|kidney development|blastocyst development|epithelial to mesenchymal transition|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|lens development in camera-type eye|ventricular trabecula myocardium morphogenesis|ventricular compact myocardium morphogenesis|proepicardium development|protein kinase activity|protein serine/threonine kinase activity|transforming growth factor beta-activated receptor activity|transforming growth factor beta receptor activity, type I|type II transforming growth factor beta receptor binding|protein binding|ATP binding|nucleus|endosome|plasma membrane|bicellular tight junction|regulation of transcription, DNA-templated|protein phosphorylation|apoptotic process|cell cycle arrest|signal transduction|transforming growth factor beta receptor signaling pathway|nervous system development|heart development|positive regulation of cell population proliferation|germ cell migration|male gonad development|post-embryonic development|anterior/posterior pattern specification|cell surface|positive regulation of gene expression|regulation of epithelial to mesenchymal transition|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|activin receptor activity, type I|protein deubiquitination|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|growth factor binding|collagen fibril organization|positive regulation of cell growth|positive regulation of cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of protein ubiquitination|negative regulation of chondrocyte differentiation|activin receptor signaling pathway|intracellular signal transduction|wound healing|endothelial cell activation|extracellular structure organization|receptor complex|regulation of protein binding|endothelial cell migration|membrane raft|positive regulation of transcription, DNA-templated|SMAD binding|metal ion binding|activin receptor complex|activin binding|thymus development|neuron fate commitment|embryonic cranial skeleton morphogenesis|skeletal system morphogenesis|mesenchymal cell differentiation|artery morphogenesis|cell motility|transforming growth factor beta binding|positive regulation of cellular component movement|positive regulation of filopodium assembly|positive regulation of stress fiber assembly|positive regulation of protein kinase B signaling|parathyroid gland development|roof of mouth development|pharyngeal system development|regulation of cardiac muscle cell proliferation|cardiac epithelial to mesenchymal transition|pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein signal transduction|ventricular septum morphogenesis|angiogenesis involved in coronary vascular morphogenesis|coronary artery morphogenesis|I-SMAD binding|response to cholesterol|cellular response to growth factor stimulus|cellular response to transforming growth factor beta stimulus|positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|positive regulation of tight junction disassembly|epicardium morphogenesis|positive regulation of apoptotic signaling pathway|negative regulation of extrinsic apoptotic signaling pathway" "hsa04010,hsa04060,hsa04068,hsa04144,hsa04218,hsa04350,hsa04371,hsa04380,hsa04390,hsa04520,hsa04659,hsa04926,hsa04933,hsa05142,hsa05161,hsa05166,hsa05200,hsa05210,hsa05212,hsa05220,hsa05225,hsa05226" MAPK signaling pathway|Cytokine-cytokine receptor interaction|FoxO signaling pathway|Endocytosis|Cellular senescence|TGF-beta signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Hippo signaling pathway|Adherens junction|Th17 cell differentiation|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Chagas disease|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer TGFBR2 6400.974456 6867.772039 5934.176872 0.864061422 -0.210794225 0.385852375 1 54.92587611 46.66516298 7048 transforming growth factor beta receptor 2 "GO:0001568,GO:0001569,GO:0001570,GO:0001666,GO:0001701,GO:0001947,GO:0002053,GO:0002088,GO:0002651,GO:0002663,GO:0002666,GO:0003148,GO:0003149,GO:0003151,GO:0003181,GO:0003186,GO:0003214,GO:0003274,GO:0003430,GO:0004674,GO:0004675,GO:0005024,GO:0005026,GO:0005515,GO:0005524,GO:0005539,GO:0005829,GO:0005886,GO:0005887,GO:0005901,GO:0006468,GO:0006898,GO:0006915,GO:0007179,GO:0007182,GO:0007219,GO:0007224,GO:0007369,GO:0007420,GO:0007507,GO:0007566,GO:0007568,GO:0007584,GO:0008284,GO:0009612,GO:0009749,GO:0009897,GO:0010468,GO:0010634,GO:0010718,GO:0016021,GO:0017002,GO:0018105,GO:0018107,GO:0030512,GO:0031100,GO:0031435,GO:0032147,GO:0032924,GO:0034713,GO:0035162,GO:0042060,GO:0042127,GO:0042493,GO:0043011,GO:0043235,GO:0043415,GO:0043627,GO:0045121,GO:0045766,GO:0046332,GO:0046872,GO:0048185,GO:0048545,GO:0048565,GO:0048661,GO:0048701,GO:0050431,GO:0051138,GO:0060044,GO:0060389,GO:0060412,GO:0060434,GO:0060440,GO:0060443,GO:0060463,GO:0062009,GO:0070723,GO:0071363,GO:1905007,GO:1905315,GO:1905316,GO:1905317,GO:1990086,GO:1990428,GO:2000379,GO:2000563" "blood vessel development|branching involved in blood vessel morphogenesis|vasculogenesis|response to hypoxia|in utero embryonic development|heart looping|positive regulation of mesenchymal cell proliferation|lens development in camera-type eye|positive regulation of tolerance induction to self antigen|positive regulation of B cell tolerance induction|positive regulation of T cell tolerance induction|outflow tract septum morphogenesis|membranous septum morphogenesis|outflow tract morphogenesis|atrioventricular valve morphogenesis|tricuspid valve morphogenesis|cardiac left ventricle morphogenesis|endocardial cushion fusion|growth plate cartilage chondrocyte growth|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|transforming growth factor beta-activated receptor activity|transforming growth factor beta receptor activity, type II|protein binding|ATP binding|glycosaminoglycan binding|cytosol|plasma membrane|integral component of plasma membrane|caveola|protein phosphorylation|receptor-mediated endocytosis|apoptotic process|transforming growth factor beta receptor signaling pathway|common-partner SMAD protein phosphorylation|Notch signaling pathway|smoothened signaling pathway|gastrulation|brain development|heart development|embryo implantation|aging|response to nutrient|positive regulation of cell population proliferation|response to mechanical stimulus|response to glucose|external side of plasma membrane|regulation of gene expression|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|integral component of membrane|activin-activated receptor activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|negative regulation of transforming growth factor beta receptor signaling pathway|animal organ regeneration|mitogen-activated protein kinase kinase kinase binding|activation of protein kinase activity|activin receptor signaling pathway|type I transforming growth factor beta receptor binding|embryonic hemopoiesis|wound healing|regulation of cell population proliferation|response to drug|myeloid dendritic cell differentiation|receptor complex|positive regulation of skeletal muscle tissue regeneration|response to estrogen|membrane raft|positive regulation of angiogenesis|SMAD binding|metal ion binding|activin binding|response to steroid hormone|digestive tract development|positive regulation of smooth muscle cell proliferation|embryonic cranial skeleton morphogenesis|transforming growth factor beta binding|positive regulation of NK T cell differentiation|negative regulation of cardiac muscle cell proliferation|pathway-restricted SMAD protein phosphorylation|ventricular septum morphogenesis|bronchus morphogenesis|trachea formation|mammary gland morphogenesis|lung lobe morphogenesis|secondary palate development|response to cholesterol|cellular response to growth factor stimulus|positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|cell proliferation involved in endocardial cushion morphogenesis|superior endocardial cushion morphogenesis|inferior endocardial cushion morphogenesis|lens fiber cell apoptotic process|miRNA transport|positive regulation of reactive oxygen species metabolic process|positive regulation of CD4-positive, alpha-beta T cell proliferation" "hsa04010,hsa04060,hsa04068,hsa04144,hsa04218,hsa04350,hsa04380,hsa04390,hsa04520,hsa04659,hsa04926,hsa04933,hsa05142,hsa05161,hsa05166,hsa05200,hsa05202,hsa05210,hsa05212,hsa05220,hsa05225,hsa05226" MAPK signaling pathway|Cytokine-cytokine receptor interaction|FoxO signaling pathway|Endocytosis|Cellular senescence|TGF-beta signaling pathway|Osteoclast differentiation|Hippo signaling pathway|Adherens junction|Th17 cell differentiation|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Chagas disease|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Colorectal cancer|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer TGFBR3 366.6294643 326.6899591 406.5689694 1.244510148 0.315577994 0.288095288 1 2.650880749 3.243842893 7049 transforming growth factor beta receptor 3 "GO:0001525,GO:0001570,GO:0001666,GO:0001837,GO:0001889,GO:0003007,GO:0003150,GO:0003151,GO:0003223,GO:0005024,GO:0005114,GO:0005160,GO:0005515,GO:0005539,GO:0005615,GO:0005737,GO:0005887,GO:0006955,GO:0007179,GO:0007181,GO:0008201,GO:0009897,GO:0009986,GO:0015026,GO:0016477,GO:0017015,GO:0017134,GO:0030165,GO:0030509,GO:0030511,GO:0030512,GO:0031012,GO:0031100,GO:0032354,GO:0034673,GO:0034695,GO:0034699,GO:0035556,GO:0043235,GO:0043393,GO:0046328,GO:0046332,GO:0048185,GO:0050431,GO:0050680,GO:0051271,GO:0055010,GO:0060038,GO:0060045,GO:0060216,GO:0060317,GO:0060318,GO:0060347,GO:0060389,GO:0060412,GO:0060939,GO:0060979,GO:0061384,GO:0062009,GO:0070062,GO:0070123,GO:0070372" "angiogenesis|vasculogenesis|response to hypoxia|epithelial to mesenchymal transition|liver development|heart morphogenesis|muscular septum morphogenesis|outflow tract morphogenesis|ventricular compact myocardium morphogenesis|transforming growth factor beta-activated receptor activity|type II transforming growth factor beta receptor binding|transforming growth factor beta receptor binding|protein binding|glycosaminoglycan binding|extracellular space|cytoplasm|integral component of plasma membrane|immune response|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor complex assembly|heparin binding|external side of plasma membrane|cell surface|coreceptor activity|cell migration|regulation of transforming growth factor beta receptor signaling pathway|fibroblast growth factor binding|PDZ domain binding|BMP signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|extracellular matrix|animal organ regeneration|response to follicle-stimulating hormone|inhibin-betaglycan-ActRII complex|response to prostaglandin E|response to luteinizing hormone|intracellular signal transduction|receptor complex|regulation of protein binding|regulation of JNK cascade|SMAD binding|activin binding|transforming growth factor beta binding|negative regulation of epithelial cell proliferation|negative regulation of cellular component movement|ventricular cardiac muscle tissue morphogenesis|cardiac muscle cell proliferation|positive regulation of cardiac muscle cell proliferation|definitive hemopoiesis|cardiac epithelial to mesenchymal transition|definitive erythrocyte differentiation|heart trabecula formation|pathway-restricted SMAD protein phosphorylation|ventricular septum morphogenesis|epicardium-derived cardiac fibroblast cell development|vasculogenesis involved in coronary vascular morphogenesis|heart trabecula morphogenesis|secondary palate development|extracellular exosome|transforming growth factor beta receptor activity, type III|regulation of ERK1 and ERK2 cascade" TGFBR3L 53.16551803 45.77821084 60.55282523 1.322743378 0.403533195 0.504263704 1 0.823146555 1.070591866 100507588 transforming growth factor beta receptor 3 like "GO:0001525,GO:0001570,GO:0001837,GO:0005024,GO:0005114,GO:0005539,GO:0005615,GO:0007179,GO:0009986,GO:0016021,GO:0016477,GO:0017015,GO:0050431" angiogenesis|vasculogenesis|epithelial to mesenchymal transition|transforming growth factor beta-activated receptor activity|type II transforming growth factor beta receptor binding|glycosaminoglycan binding|extracellular space|transforming growth factor beta receptor signaling pathway|cell surface|integral component of membrane|cell migration|regulation of transforming growth factor beta receptor signaling pathway|transforming growth factor beta binding TGFBRAP1 819.9246677 947.8170471 692.0322883 0.730132772 -0.453769257 0.070402946 1 7.535118991 5.40957487 9392 transforming growth factor beta receptor associated protein 1 "GO:0005160,GO:0005515,GO:0005737,GO:0005769,GO:0006355,GO:0006886,GO:0006914,GO:0007165,GO:0007179,GO:0008333,GO:0016020,GO:0033263,GO:0034058,GO:0043231,GO:0046332" "transforming growth factor beta receptor binding|protein binding|cytoplasm|early endosome|regulation of transcription, DNA-templated|intracellular protein transport|autophagy|signal transduction|transforming growth factor beta receptor signaling pathway|endosome to lysosome transport|membrane|CORVET complex|endosomal vesicle fusion|intracellular membrane-bounded organelle|SMAD binding" TGIF1 1506.676973 1528.367994 1484.985952 0.971615447 -0.041542668 0.864375143 1 17.09983036 16.33643885 7050 TGFB induced factor homeobox 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005654,GO:0006357,GO:0042493,GO:0070410,GO:0071363,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|response to drug|co-SMAD binding|cellular response to growth factor stimulus|sequence-specific double-stranded DNA binding" hsa04350 TGF-beta signaling pathway TGIF2 398.9068323 429.6909335 368.1227311 0.856715147 -0.223112499 0.443338753 1 6.54260068 5.511350589 60436 TGFB induced factor homeobox 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0005654,GO:0005813,GO:0006355,GO:0006357,GO:0010470,GO:0038092,GO:0045666,GO:0060041,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|centrosome|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|regulation of gastrulation|nodal signaling pathway|positive regulation of neuron differentiation|retina development in camera-type eye|sequence-specific double-stranded DNA binding" hsa04350 TGF-beta signaling pathway TGM1 13.69395716 6.242483296 21.14543103 3.38734283 1.760154008 0.087326476 1 0.121410299 0.404376455 7051 transglutaminase 1 "GO:0001533,GO:0003810,GO:0005515,GO:0005829,GO:0005886,GO:0006464,GO:0010838,GO:0016020,GO:0018149,GO:0018215,GO:0030216,GO:0031224,GO:0042802,GO:0043163,GO:0045787,GO:0046872,GO:0070062,GO:0070268" cornified envelope|protein-glutamine gamma-glutamyltransferase activity|protein binding|cytosol|plasma membrane|cellular protein modification process|positive regulation of keratinocyte proliferation|membrane|peptide cross-linking|protein phosphopantetheinylation|keratinocyte differentiation|intrinsic component of membrane|identical protein binding|cell envelope organization|positive regulation of cell cycle|metal ion binding|extracellular exosome|cornification TGM2 21376.68846 21918.39927 20834.97766 0.950570222 -0.073134887 0.79108092 1 222.9783996 208.4098198 7052 transglutaminase 2 "GO:0001974,GO:0003810,GO:0005515,GO:0005525,GO:0005739,GO:0005783,GO:0005829,GO:0005886,GO:0005925,GO:0018149,GO:0018153,GO:0018215,GO:0019904,GO:0031226,GO:0032471,GO:0042802,GO:0043065,GO:0043123,GO:0043277,GO:0045785,GO:0046872,GO:0048661,GO:0050729,GO:0051482,GO:0051561,GO:0060445,GO:0060662,GO:0062023,GO:0070062" blood vessel remodeling|protein-glutamine gamma-glutamyltransferase activity|protein binding|GTP binding|mitochondrion|endoplasmic reticulum|cytosol|plasma membrane|focal adhesion|peptide cross-linking|isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|protein phosphopantetheinylation|protein domain specific binding|intrinsic component of plasma membrane|negative regulation of endoplasmic reticulum calcium ion concentration|identical protein binding|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|apoptotic cell clearance|positive regulation of cell adhesion|metal ion binding|positive regulation of smooth muscle cell proliferation|positive regulation of inflammatory response|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|positive regulation of mitochondrial calcium ion concentration|branching involved in salivary gland morphogenesis|salivary gland cavitation|collagen-containing extracellular matrix|extracellular exosome hsa05016 Huntington disease TGM4 5.524131538 6.242483296 4.80577978 0.769850643 -0.377349516 0.927604977 1 0.106200147 0.080390138 7047 transglutaminase 4 "GO:0003810,GO:0005737,GO:0005794,GO:0018149,GO:0018215,GO:0046872,GO:0062023,GO:0070062" protein-glutamine gamma-glutamyltransferase activity|cytoplasm|Golgi apparatus|peptide cross-linking|protein phosphopantetheinylation|metal ion binding|collagen-containing extracellular matrix|extracellular exosome TGOLN2 9455.260474 9321.067975 9589.452973 1.028793374 0.040953256 0.870256915 1 81.44208684 82.38501602 10618 trans-golgi network protein 2 "GO:0005515,GO:0005654,GO:0005768,GO:0005788,GO:0005794,GO:0005802,GO:0005886,GO:0016021,GO:0030133,GO:0030140,GO:0030665,GO:0043687,GO:0044267,GO:0061024" protein binding|nucleoplasm|endosome|endoplasmic reticulum lumen|Golgi apparatus|trans-Golgi network|plasma membrane|integral component of membrane|transport vesicle|trans-Golgi network transport vesicle|clathrin-coated vesicle membrane|post-translational protein modification|cellular protein metabolic process|membrane organization TGS1 830.0866167 873.9476614 786.225572 0.899625466 -0.152603595 0.544508516 1 13.40258059 11.85554017 96764 trimethylguanosine synthase 1 "GO:0000387,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0008173,GO:0009452,GO:0015030,GO:0019216,GO:0022613,GO:0030532,GO:0036261,GO:0071164" spliceosomal snRNP assembly|protein binding|extracellular space|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|RNA methyltransferase activity|7-methylguanosine RNA capping|Cajal body|regulation of lipid metabolic process|ribonucleoprotein complex biogenesis|small nuclear ribonucleoprotein complex|7-methylguanosine cap hypermethylation|RNA trimethylguanosine synthase activity hsa03013 RNA transport TH 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.086757776 0.131345761 7054 tyrosine hydroxylase "GO:0001666,GO:0001963,GO:0001975,GO:0003007,GO:0004511,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005790,GO:0005829,GO:0006585,GO:0006631,GO:0006665,GO:0007507,GO:0007601,GO:0007605,GO:0007612,GO:0007613,GO:0007617,GO:0007626,GO:0008016,GO:0008021,GO:0008198,GO:0008199,GO:0009414,GO:0009416,GO:0009635,GO:0009651,GO:0009653,GO:0009887,GO:0009898,GO:0010043,GO:0010259,GO:0014823,GO:0015842,GO:0016137,GO:0016597,GO:0018963,GO:0019825,GO:0019899,GO:0019904,GO:0021987,GO:0030424,GO:0030425,GO:0031410,GO:0031667,GO:0032355,GO:0032496,GO:0033076,GO:0033162,GO:0034617,GO:0035176,GO:0035240,GO:0035690,GO:0035900,GO:0035902,GO:0042136,GO:0042214,GO:0042416,GO:0042418,GO:0042421,GO:0042423,GO:0042462,GO:0042745,GO:0042755,GO:0043005,GO:0043195,GO:0043204,GO:0043434,GO:0043473,GO:0045471,GO:0045472,GO:0046684,GO:0048471,GO:0048596,GO:0051412,GO:0051602,GO:0052314,GO:0055114,GO:0071287,GO:0071312,GO:0071316,GO:0071333,GO:0071363,GO:1990384" "response to hypoxia|synaptic transmission, dopaminergic|response to amphetamine|heart morphogenesis|tyrosine 3-monooxygenase activity|protein binding|nucleus|cytoplasm|mitochondrion|smooth endoplasmic reticulum|cytosol|dopamine biosynthetic process from tyrosine|fatty acid metabolic process|sphingolipid metabolic process|heart development|visual perception|sensory perception of sound|learning|memory|mating behavior|locomotory behavior|regulation of heart contraction|synaptic vesicle|ferrous iron binding|ferric iron binding|response to water deprivation|response to light stimulus|response to herbicide|response to salt stress|anatomical structure morphogenesis|animal organ morphogenesis|cytoplasmic side of plasma membrane|response to zinc ion|multicellular organism aging|response to activity|aminergic neurotransmitter loading into synaptic vesicle|glycoside metabolic process|amino acid binding|phthalate metabolic process|oxygen binding|enzyme binding|protein domain specific binding|cerebral cortex development|axon|dendrite|cytoplasmic vesicle|response to nutrient levels|response to estradiol|response to lipopolysaccharide|isoquinoline alkaloid metabolic process|melanosome membrane|tetrahydrobiopterin binding|social behavior|dopamine binding|cellular response to drug|response to isolation stress|response to immobilization stress|neurotransmitter biosynthetic process|terpene metabolic process|dopamine biosynthetic process|epinephrine biosynthetic process|norepinephrine biosynthetic process|catecholamine biosynthetic process|eye photoreceptor cell development|circadian sleep/wake cycle|eating behavior|neuron projection|terminal bouton|perikaryon|response to peptide hormone|pigmentation|response to ethanol|response to ether|response to pyrethroid|perinuclear region of cytoplasm|embryonic camera-type eye morphogenesis|response to corticosterone|response to electrical stimulus|phytoalexin metabolic process|oxidation-reduction process|cellular response to manganese ion|cellular response to alkaloid|cellular response to nicotine|cellular response to glucose stimulus|cellular response to growth factor stimulus|hyaloid vascular plexus regression" "hsa00350,hsa00790,hsa04728,hsa04917,hsa05012,hsa05030,hsa05031,hsa05034" Tyrosine metabolism|Folate biosynthesis|Dopaminergic synapse|Prolactin signaling pathway|Parkinson disease|Cocaine addiction|Amphetamine addiction|Alcoholism THADA 636.0677061 738.6938567 533.4415556 0.722141589 -0.469646363 0.070917551 1 5.63584467 4.001773933 63892 THADA armadillo repeat containing "GO:0005515,GO:0005829,GO:0030488,GO:0032471,GO:0055088,GO:0098554,GO:1901895,GO:1990845" protein binding|cytosol|tRNA methylation|negative regulation of endoplasmic reticulum calcium ion concentration|lipid homeostasis|cytoplasmic side of endoplasmic reticulum membrane|negative regulation of ATPase-coupled calcium transmembrane transporter activity|adaptive thermogenesis THAP1 175.1423913 169.5874629 180.6973197 1.065511074 0.091545588 0.824358744 1 4.188140308 4.387835819 55145 THAP domain containing 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001650,GO:0001935,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0006357,GO:0007049,GO:0007346,GO:0008270,GO:0016605,GO:0042802,GO:0042803,GO:0043231,GO:0043565" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|fibrillar center|endothelial cell proliferation|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|cell cycle|regulation of mitotic cell cycle|zinc ion binding|PML body|identical protein binding|protein homodimerization activity|intracellular membrane-bounded organelle|sequence-specific DNA binding" THAP THAP10 110.7751248 94.67766332 126.8725862 1.340047713 0.422284369 0.353793784 1 2.468379522 3.252395677 56906 THAP domain containing 10 "GO:0003677,GO:0005515,GO:0046872" DNA binding|protein binding|metal ion binding THAP11 495.7898551 512.9240441 478.6556661 0.933190151 -0.099757014 0.721050027 1 14.59158503 13.38886601 57215 THAP domain containing 11 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0008270" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|zinc ion binding" THAP THAP12 1380.161662 1436.811572 1323.511751 0.921144969 -0.11849987 0.622664985 1 21.97134466 19.9001248 5612 THAP domain containing 12 "GO:0003677,GO:0005515,GO:0005634,GO:0007165,GO:0008285,GO:0046872,GO:0046983" DNA binding|protein binding|nucleus|signal transduction|negative regulation of cell population proliferation|metal ion binding|protein dimerization activity THAP2 104.0124345 81.15228285 126.8725862 1.563388998 0.644676791 0.163358572 1 0.9771995 1.502178238 83591 THAP domain containing 2 "GO:0003677,GO:0005634,GO:0005730,GO:0046872" DNA binding|nucleus|nucleolus|metal ion binding THAP3 301.3205491 302.7604398 299.8806583 0.99048825 -0.013788234 0.976829486 1 4.331841347 4.21883994 90326 THAP domain containing 3 "GO:0003677,GO:0005515,GO:0045944,GO:0046872" DNA binding|protein binding|positive regulation of transcription by RNA polymerase II|metal ion binding THAP4 1426.257519 1435.771158 1416.743879 0.986747694 -0.019246852 0.93898644 1 31.90027805 30.95079203 51078 THAP domain containing 4 "GO:0003677,GO:0005515,GO:0005575,GO:0006570,GO:0020037,GO:0042126,GO:0042802,GO:0046872,GO:0062213,GO:0070026" DNA binding|protein binding|cellular_component|tyrosine metabolic process|heme binding|nitrate metabolic process|identical protein binding|metal ion binding|peroxynitrite isomerase activity|nitric oxide binding THAP5 607.1745056 585.7530159 628.5959952 1.073141714 0.101840604 0.70237841 1 8.224299366 8.678150256 168451 THAP domain containing 5 "GO:0000122,GO:0000785,GO:0002020,GO:0003677,GO:0005634,GO:0005654,GO:0007049,GO:0045786,GO:0046872" negative regulation of transcription by RNA polymerase II|chromatin|protease binding|DNA binding|nucleus|nucleoplasm|cell cycle|negative regulation of cell cycle|metal ion binding THAP6 372.8964853 377.6702394 368.1227311 0.974719988 -0.036940266 0.909652244 1 3.430150876 3.287488736 152815 THAP domain containing 6 "GO:0003677,GO:0005515,GO:0015630,GO:0046872" DNA binding|protein binding|microtubule cytoskeleton|metal ion binding THAP7 174.5032975 165.4258073 183.5807876 1.109746965 0.150230763 0.705694053 1 5.085524941 5.549207097 80764 THAP domain containing 7 "GO:0000122,GO:0001226,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006355,GO:0016607,GO:0031493,GO:0031965,GO:0035064,GO:0035067,GO:0042802,GO:0042826,GO:0043231,GO:0045892,GO:0046872,GO:0047485,GO:0070577,GO:0070742,GO:0106153,GO:0140296" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription corepressor binding|DNA binding|protein binding|nucleus|nucleoplasm|chromosome|regulation of transcription, DNA-templated|nuclear speck|nucleosomal histone binding|nuclear membrane|methylated histone binding|negative regulation of histone acetylation|identical protein binding|histone deacetylase binding|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated|metal ion binding|protein N-terminus binding|lysine-acetylated histone binding|C2H2 zinc finger domain binding|phosphorylated histone binding|general transcription initiation factor binding" THAP8 47.55206773 62.42483296 32.6793025 0.523498437 -0.933742864 0.126536864 1 1.889675895 0.972688747 199745 THAP domain containing 8 "GO:0003677,GO:0005515,GO:0046872" DNA binding|protein binding|metal ion binding THAP9 87.94515559 100.9201466 74.97016457 0.742866188 -0.428825733 0.386009251 1 1.234736988 0.901895517 79725 THAP domain containing 9 "GO:0003677,GO:0004803,GO:0006310,GO:0006313,GO:0015074,GO:0016740,GO:0043565,GO:0046872" "DNA binding|transposase activity|DNA recombination|transposition, DNA-mediated|DNA integration|transferase activity|sequence-specific DNA binding|metal ion binding" THBD 2111.52969 1813.441397 2409.617982 1.32875426 0.410074317 0.083041822 1 23.95545406 31.29826443 7056 thrombomodulin "GO:0004888,GO:0005509,GO:0005515,GO:0005615,GO:0005774,GO:0005886,GO:0005887,GO:0007565,GO:0007596,GO:0009897,GO:0009986,GO:0010165,GO:0010544,GO:0016327,GO:0030195,GO:0032496,GO:0038023,GO:0050900,GO:0051591,GO:0051918" transmembrane signaling receptor activity|calcium ion binding|protein binding|extracellular space|vacuolar membrane|plasma membrane|integral component of plasma membrane|female pregnancy|blood coagulation|external side of plasma membrane|cell surface|response to X-ray|negative regulation of platelet activation|apicolateral plasma membrane|negative regulation of blood coagulation|response to lipopolysaccharide|signaling receptor activity|leukocyte migration|response to cAMP|negative regulation of fibrinolysis "hsa04610,hsa04933,hsa05418" Complement and coagulation cascades|AGE-RAGE signaling pathway in diabetic complications|Fluid shear stress and atherosclerosis THBS1 914.5639308 934.2916666 894.836195 0.957769642 -0.062249387 0.805523087 1 8.611645784 8.109954243 7057 thrombospondin 1 "GO:0000187,GO:0001666,GO:0001786,GO:0001937,GO:0001953,GO:0001968,GO:0002040,GO:0002544,GO:0002576,GO:0002581,GO:0002605,GO:0005178,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005577,GO:0005615,GO:0005783,GO:0005788,GO:0006954,GO:0006955,GO:0006986,GO:0007050,GO:0007155,GO:0008201,GO:0008284,GO:0009612,GO:0009749,GO:0009897,GO:0009986,GO:0010595,GO:0010596,GO:0010748,GO:0010751,GO:0010754,GO:0010757,GO:0010759,GO:0010763,GO:0016477,GO:0016525,GO:0016529,GO:0017134,GO:0018149,GO:0030141,GO:0030169,GO:0030194,GO:0030198,GO:0030335,GO:0030511,GO:0031012,GO:0031091,GO:0031093,GO:0032026,GO:0032570,GO:0032695,GO:0032760,GO:0032914,GO:0033574,GO:0034605,GO:0034976,GO:0040037,GO:0042327,GO:0042493,GO:0042802,GO:0043032,GO:0043066,GO:0043154,GO:0043236,GO:0043394,GO:0043536,GO:0043537,GO:0043652,GO:0045652,GO:0045727,GO:0045766,GO:0048266,GO:0048661,GO:0050431,GO:0050921,GO:0051592,GO:0051895,GO:0051897,GO:0051918,GO:0062023,GO:0070051,GO:0070052,GO:0070062,GO:0071356,GO:0071363,GO:0090051,GO:1902043,GO:1903588,GO:1903671,GO:2000353,GO:2000379,GO:2001027,GO:2001237" activation of MAPK activity|response to hypoxia|phosphatidylserine binding|negative regulation of endothelial cell proliferation|negative regulation of cell-matrix adhesion|fibronectin binding|sprouting angiogenesis|chronic inflammatory response|platelet degranulation|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of dendritic cell antigen processing and presentation|integrin binding|extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|fibrinogen complex|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|inflammatory response|immune response|response to unfolded protein|cell cycle arrest|cell adhesion|heparin binding|positive regulation of cell population proliferation|response to mechanical stimulus|response to glucose|external side of plasma membrane|cell surface|positive regulation of endothelial cell migration|negative regulation of endothelial cell migration|negative regulation of long-chain fatty acid import across plasma membrane|negative regulation of nitric oxide mediated signal transduction|negative regulation of cGMP-mediated signaling|negative regulation of plasminogen activation|positive regulation of macrophage chemotaxis|positive regulation of fibroblast migration|cell migration|negative regulation of angiogenesis|sarcoplasmic reticulum|fibroblast growth factor binding|peptide cross-linking|secretory granule|low-density lipoprotein particle binding|positive regulation of blood coagulation|extracellular matrix organization|positive regulation of cell migration|positive regulation of transforming growth factor beta receptor signaling pathway|extracellular matrix|platelet alpha granule|platelet alpha granule lumen|response to magnesium ion|response to progesterone|negative regulation of interleukin-12 production|positive regulation of tumor necrosis factor production|positive regulation of transforming growth factor beta1 production|response to testosterone|cellular response to heat|response to endoplasmic reticulum stress|negative regulation of fibroblast growth factor receptor signaling pathway|positive regulation of phosphorylation|response to drug|identical protein binding|positive regulation of macrophage activation|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|laminin binding|proteoglycan binding|positive regulation of blood vessel endothelial cell migration|negative regulation of blood vessel endothelial cell migration|engulfment of apoptotic cell|regulation of megakaryocyte differentiation|positive regulation of translation|positive regulation of angiogenesis|behavioral response to pain|positive regulation of smooth muscle cell proliferation|transforming growth factor beta binding|positive regulation of chemotaxis|response to calcium ion|negative regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|negative regulation of fibrinolysis|collagen-containing extracellular matrix|fibrinogen binding|collagen V binding|extracellular exosome|cellular response to tumor necrosis factor|cellular response to growth factor stimulus|negative regulation of cell migration involved in sprouting angiogenesis|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|negative regulation of sprouting angiogenesis|positive regulation of endothelial cell apoptotic process|positive regulation of reactive oxygen species metabolic process|negative regulation of endothelial cell chemotaxis|negative regulation of extrinsic apoptotic signaling pathway "hsa04015,hsa04115,hsa04145,hsa04151,hsa04350,hsa04510,hsa04512,hsa05144,hsa05165,hsa05205,hsa05206,hsa05219" Rap1 signaling pathway|p53 signaling pathway|Phagosome|PI3K-Akt signaling pathway|TGF-beta signaling pathway|Focal adhesion|ECM-receptor interaction|Malaria|Human papillomavirus infection|Proteoglycans in cancer|MicroRNAs in cancer|Bladder cancer THBS2 601.1100454 628.4099851 573.8101057 0.91311424 -0.131132728 0.621478206 1 5.11626025 4.593555011 7058 thrombospondin 2 "GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0007155,GO:0008201,GO:0016525,GO:0031091,GO:0062023" extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|cell adhesion|heparin binding|negative regulation of angiogenesis|platelet alpha granule|collagen-containing extracellular matrix "hsa04145,hsa04151,hsa04510,hsa04512,hsa05144,hsa05165" Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Malaria|Human papillomavirus infection THBS3 322.4458584 352.7003062 292.1914106 0.828441046 -0.27152906 0.37973164 1 3.754830861 3.058603391 7059 thrombospondin 3 "GO:0003417,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0007160,GO:0008201,GO:0043931,GO:0048471,GO:0060346,GO:0062023" growth plate cartilage development|extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|cell-matrix adhesion|heparin binding|ossification involved in bone maturation|perinuclear region of cytoplasm|bone trabecula formation|collagen-containing extracellular matrix "hsa04145,hsa04151,hsa04510,hsa04512,hsa05144,hsa05165" Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Malaria|Human papillomavirus infection THBS4 11.00863411 11.44455271 10.57271552 0.923820772 -0.11431511 1 1 0.157254054 0.142843588 7060 thrombospondin 4 "GO:0001938,GO:0005178,GO:0005509,GO:0005515,GO:0005576,GO:0005604,GO:0005615,GO:0005783,GO:0006986,GO:0007165,GO:0008083,GO:0008201,GO:0016525,GO:0016529,GO:0034103,GO:0034976,GO:0048266,GO:0048771,GO:0050731,GO:0051451,GO:0051781,GO:0062023,GO:0070062,GO:0071603,GO:0090023" positive regulation of endothelial cell proliferation|integrin binding|calcium ion binding|protein binding|extracellular region|basement membrane|extracellular space|endoplasmic reticulum|response to unfolded protein|signal transduction|growth factor activity|heparin binding|negative regulation of angiogenesis|sarcoplasmic reticulum|regulation of tissue remodeling|response to endoplasmic reticulum stress|behavioral response to pain|tissue remodeling|positive regulation of peptidyl-tyrosine phosphorylation|myoblast migration|positive regulation of cell division|collagen-containing extracellular matrix|extracellular exosome|endothelial cell-cell adhesion|positive regulation of neutrophil chemotaxis "hsa04145,hsa04151,hsa04510,hsa04512,hsa05144,hsa05165" Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Malaria|Human papillomavirus infection THEM4 266.4610392 346.4578229 186.4642555 0.538201891 -0.893780635 0.006526848 0.483289646 3.828119513 2.025824811 117145 thioesterase superfamily member 4 "GO:0005515,GO:0005739,GO:0005743,GO:0005758,GO:0005759,GO:0005829,GO:0005886,GO:0006631,GO:0006637,GO:0016290,GO:0032587,GO:0043491,GO:0051898,GO:0102991,GO:1902108" protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|cytosol|plasma membrane|fatty acid metabolic process|acyl-CoA metabolic process|palmitoyl-CoA hydrolase activity|ruffle membrane|protein kinase B signaling|negative regulation of protein kinase B signaling|myristoyl-CoA hydrolase activity|regulation of mitochondrial membrane permeability involved in apoptotic process "hsa00062,hsa04151" Fatty acid elongation|PI3K-Akt signaling pathway THEM6 65.04095892 92.59683556 37.48508228 0.404820338 -1.304646322 0.017405503 0.770503287 2.375828331 0.945689482 51337 thioesterase superfamily member 6 GO:0005576 extracellular region THEMIS2 95.72875242 65.54607461 125.9114302 1.920960652 0.941827968 0.04814221 1 1.494903219 2.823597085 9473 thymocyte selection associated family member 2 "GO:0005515,GO:0005634,GO:0005737,GO:0006954,GO:0007155,GO:0050852" protein binding|nucleus|cytoplasm|inflammatory response|cell adhesion|T cell receptor signaling pathway THG1L 558.9978209 582.6317743 535.3638675 0.918871732 -0.12206461 0.651309705 1 9.500148781 8.583343173 54974 tRNA-histidine guanylyltransferase 1 like "GO:0000049,GO:0000287,GO:0005085,GO:0005515,GO:0005524,GO:0005525,GO:0005739,GO:0005741,GO:0005829,GO:0006400,GO:0006979,GO:0008033,GO:0008053,GO:0008193,GO:0016779,GO:0042802,GO:0050790,GO:0051289,GO:0099116,GO:1990046,GO:1990234" tRNA binding|magnesium ion binding|guanyl-nucleotide exchange factor activity|protein binding|ATP binding|GTP binding|mitochondrion|mitochondrial outer membrane|cytosol|tRNA modification|response to oxidative stress|tRNA processing|mitochondrial fusion|tRNA guanylyltransferase activity|nucleotidyltransferase activity|identical protein binding|regulation of catalytic activity|protein homotetramerization|tRNA 5'-end processing|stress-induced mitochondrial fusion|transferase complex THNSL1 88.74779569 96.75849109 80.7371003 0.834418762 -0.261156498 0.604952778 1 1.280075071 1.050245136 79896 threonine synthase like 1 "GO:0003674,GO:0005575,GO:0008150" molecular_function|cellular_component|biological_process THOC1 663.0750365 602.399638 723.7504349 1.201445667 0.264771407 0.306300862 1 8.298647785 9.803533709 9984 THO complex 1 "GO:0000018,GO:0000346,GO:0000347,GO:0000445,GO:0000781,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006396,GO:0006405,GO:0006406,GO:0006915,GO:0007165,GO:0008380,GO:0016363,GO:0016607,GO:0031124,GO:0031297,GO:0032784,GO:0032786,GO:0046784,GO:0048297,GO:2000002" "regulation of DNA recombination|transcription export complex|THO complex|THO complex part of transcription export complex|chromosome, telomeric region|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|RNA processing|RNA export from nucleus|mRNA export from nucleus|apoptotic process|signal transduction|RNA splicing|nuclear matrix|nuclear speck|mRNA 3'-end processing|replication fork processing|regulation of DNA-templated transcription, elongation|positive regulation of DNA-templated transcription, elongation|viral mRNA export from host cell nucleus|negative regulation of isotype switching to IgA isotypes|negative regulation of DNA damage checkpoint" "hsa03013,hsa03040" RNA transport|Spliceosome THOC2 2561.642672 2679.065748 2444.219596 0.912340281 -0.13235608 0.576209552 1 18.34447204 16.45633976 57187 THO complex 2 "GO:0000346,GO:0000347,GO:0000445,GO:0000781,GO:0003729,GO:0005515,GO:0005654,GO:0006405,GO:0006406,GO:0008380,GO:0016607,GO:0016973,GO:0031124,GO:0046784,GO:0048666,GO:0048699" "transcription export complex|THO complex|THO complex part of transcription export complex|chromosome, telomeric region|mRNA binding|protein binding|nucleoplasm|RNA export from nucleus|mRNA export from nucleus|RNA splicing|nuclear speck|poly(A)+ mRNA export from nucleus|mRNA 3'-end processing|viral mRNA export from host cell nucleus|neuron development|generation of neurons" "hsa03013,hsa03040" RNA transport|Spliceosome THOC3 678.428994 563.9043244 792.9536637 1.406184754 0.491786158 0.056148731 1 11.13375412 15.39413141 84321 THO complex 3 "GO:0000346,GO:0000445,GO:0000781,GO:0003723,GO:0005654,GO:0006405,GO:0006406,GO:0008380,GO:0016607,GO:0031124,GO:0046784" "transcription export complex|THO complex part of transcription export complex|chromosome, telomeric region|RNA binding|nucleoplasm|RNA export from nucleus|mRNA export from nucleus|RNA splicing|nuclear speck|mRNA 3'-end processing|viral mRNA export from host cell nucleus" "hsa03013,hsa03040" RNA transport|Spliceosome THOC5 1329.309715 1413.922467 1244.696963 0.880314863 -0.183908468 0.444836375 1 14.49451467 12.54621979 8563 THO complex 5 "GO:0000346,GO:0000347,GO:0000445,GO:0000781,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006405,GO:0006406,GO:0008380,GO:0030224,GO:0031124,GO:0032786,GO:0046784,GO:0060215,GO:2000002" "transcription export complex|THO complex|THO complex part of transcription export complex|chromosome, telomeric region|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|RNA export from nucleus|mRNA export from nucleus|RNA splicing|monocyte differentiation|mRNA 3'-end processing|positive regulation of DNA-templated transcription, elongation|viral mRNA export from host cell nucleus|primitive hemopoiesis|negative regulation of DNA damage checkpoint" hsa03013 RNA transport THOC6 493.7536867 497.3178359 490.1895376 0.985666514 -0.020828481 0.947408426 1 20.33788419 19.71092253 79228 THO complex 6 "GO:0000346,GO:0000347,GO:0000445,GO:0000781,GO:0003723,GO:0005634,GO:0005654,GO:0006405,GO:0006406,GO:0006915,GO:0007417,GO:0008380,GO:0016604,GO:0016607,GO:0031124,GO:0043066,GO:0046784" "transcription export complex|THO complex|THO complex part of transcription export complex|chromosome, telomeric region|RNA binding|nucleus|nucleoplasm|RNA export from nucleus|mRNA export from nucleus|apoptotic process|central nervous system development|RNA splicing|nuclear body|nuclear speck|mRNA 3'-end processing|negative regulation of apoptotic process|viral mRNA export from host cell nucleus" hsa03013 RNA transport THOC7 728.5273763 667.9457127 789.1090399 1.181396968 0.240493815 0.346085136 1 28.26886206 32.83789858 80145 THO complex 7 "GO:0000346,GO:0000347,GO:0000445,GO:0000781,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006405,GO:0006406,GO:0008380,GO:0016607,GO:0031124,GO:0046784" "transcription export complex|THO complex|THO complex part of transcription export complex|chromosome, telomeric region|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|RNA splicing|nuclear speck|mRNA 3'-end processing|viral mRNA export from host cell nucleus" hsa03013 RNA transport THOP1 1425.677561 1483.630197 1367.724925 0.92187725 -0.11735343 0.625351653 1 18.43936115 16.71437519 7064 thimet oligopeptidase 1 "GO:0000209,GO:0004222,GO:0005515,GO:0005758,GO:0005829,GO:0006508,GO:0006518,GO:0042277,GO:0046872" protein polyubiquitination|metalloendopeptidase activity|protein binding|mitochondrial intermembrane space|cytosol|proteolysis|peptide metabolic process|peptide binding|metal ion binding "hsa04614,hsa05143" Renin-angiotensin system|African trypanosomiasis THRA 810.174714 893.7155252 726.6339027 0.813048316 -0.298587007 0.234800342 1 7.557590715 6.041863398 7067 thyroid hormone receptor alpha "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001502,GO:0001503,GO:0002154,GO:0002155,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006366,GO:0006367,GO:0007611,GO:0008016,GO:0008050,GO:0008134,GO:0008270,GO:0009409,GO:0009755,GO:0017025,GO:0017055,GO:0019904,GO:0030154,GO:0030218,GO:0030878,GO:0031490,GO:0033032,GO:0044877,GO:0045892,GO:0045925,GO:0045944,GO:0050994,GO:0060509,GO:0070324,GO:0120162,GO:2000143" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cartilage condensation|ossification|thyroid hormone mediated signaling pathway|regulation of thyroid hormone mediated signaling pathway|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|learning or memory|regulation of heart contraction|female courtship behavior|transcription factor binding|zinc ion binding|response to cold|hormone-mediated signaling pathway|TBP-class protein binding|negative regulation of RNA polymerase II transcription preinitiation complex assembly|protein domain specific binding|cell differentiation|erythrocyte differentiation|thyroid gland development|chromatin DNA binding|regulation of myeloid cell apoptotic process|protein-containing complex binding|negative regulation of transcription, DNA-templated|positive regulation of female receptivity|positive regulation of transcription by RNA polymerase II|regulation of lipid catabolic process|type I pneumocyte differentiation|thyroid hormone binding|positive regulation of cold-induced thermogenesis|negative regulation of DNA-templated transcription, initiation" "hsa04080,hsa04919" Neuroactive ligand-receptor interaction|Thyroid hormone signaling pathway THRAP3 2949.525779 3134.767028 2764.284529 0.881814982 -0.181452107 0.443536547 1 33.92067211 29.41122411 9967 thyroid hormone receptor associated protein 3 "GO:0000381,GO:0000956,GO:0000978,GO:0003677,GO:0003712,GO:0003713,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006397,GO:0008380,GO:0016592,GO:0016607,GO:0030374,GO:0035145,GO:0042753,GO:0042809,GO:0045893,GO:0045944,GO:0046966,GO:0048026,GO:0048255,GO:0048511,GO:0051219,GO:0070062" "regulation of alternative mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA binding|transcription coregulator activity|transcription coactivator activity|RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|mRNA processing|RNA splicing|mediator complex|nuclear speck|nuclear receptor coactivator activity|exon-exon junction complex|positive regulation of circadian rhythm|vitamin D receptor binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|thyroid hormone receptor binding|positive regulation of mRNA splicing, via spliceosome|mRNA stabilization|rhythmic process|phosphoprotein binding|extracellular exosome" THRB 232.9205747 197.6786377 268.1625117 1.35655787 0.439950594 0.200909718 1 0.97457234 1.29994083 7068 thyroid hormone receptor beta "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001225,GO:0002154,GO:0003677,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0006351,GO:0006367,GO:0007605,GO:0007621,GO:0008016,GO:0008050,GO:0008270,GO:0009755,GO:0016604,GO:0019899,GO:0030154,GO:0031490,GO:0042480,GO:0045944,GO:0046549,GO:0060509,GO:0070324,GO:0097067,GO:0097474,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription coactivator binding|thyroid hormone mediated signaling pathway|DNA binding|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|sensory perception of sound|negative regulation of female receptivity|regulation of heart contraction|female courtship behavior|zinc ion binding|hormone-mediated signaling pathway|nuclear body|enzyme binding|cell differentiation|chromatin DNA binding|negative regulation of eye photoreceptor cell development|positive regulation of transcription by RNA polymerase II|retinal cone cell development|type I pneumocyte differentiation|thyroid hormone binding|cellular response to thyroid hormone stimulus|retinal cone cell apoptotic process|sequence-specific double-stranded DNA binding" "hsa04080,hsa04919" Neuroactive ligand-receptor interaction|Thyroid hormone signaling pathway THSD1 402.9797835 359.9832034 445.9763636 1.238881035 0.309037658 0.285359626 1 6.348857219 7.733860666 55901 thrombospondin type 1 domain containing 1 "GO:0005515,GO:0005576,GO:0005768,GO:0005829,GO:0005925,GO:0010008,GO:0016021,GO:0048041,GO:0050840,GO:0071944" protein binding|extracellular region|endosome|cytosol|focal adhesion|endosome membrane|integral component of membrane|focal adhesion assembly|extracellular matrix binding|cell periphery THSD4 4313.404353 4232.403675 4394.405031 1.038276443 0.054190614 0.821183991 1 15.68689529 16.01478736 79875 thrombospondin type 1 domain containing 4 "GO:0001527,GO:0004222,GO:0005201,GO:0006508,GO:0030198,GO:0031012,GO:0048251,GO:0062023,GO:0070062" microfibril|metalloendopeptidase activity|extracellular matrix structural constituent|proteolysis|extracellular matrix organization|extracellular matrix|elastic fiber assembly|collagen-containing extracellular matrix|extracellular exosome hsa04350 TGF-beta signaling pathway THSD7A 3.522561699 4.161655531 2.883467868 0.692865579 -0.529352609 0.940314863 1 0.016297322 0.0111029 221981 thrombospondin type 1 domain containing 7A "GO:0001525,GO:0005515,GO:0005576,GO:0005886,GO:0016021,GO:0030154,GO:0031532,GO:0042995" angiogenesis|protein binding|extracellular region|plasma membrane|integral component of membrane|cell differentiation|actin cytoskeleton reorganization|cell projection THSD7B 12.48999701 12.48496659 12.49502743 1.000805836 0.001162108 1 1 0.103030728 0.101388285 80731 thrombospondin type 1 domain containing 7B "GO:0005886,GO:0016021,GO:0031532" plasma membrane|integral component of membrane|actin cytoskeleton reorganization THTPA 154.2793934 164.3853935 144.1733934 0.877045036 -0.189277168 0.64714928 1 3.025153904 2.60879857 79178 thiamine triphosphatase "GO:0000287,GO:0005515,GO:0005829,GO:0006091,GO:0006772,GO:0016311,GO:0016787,GO:0042357,GO:0042723,GO:0050333" magnesium ion binding|protein binding|cytosol|generation of precursor metabolites and energy|thiamine metabolic process|dephosphorylation|hydrolase activity|thiamine diphosphate metabolic process|thiamine-containing compound metabolic process|thiamin-triphosphatase activity hsa00730 Thiamine metabolism THUMPD1 1036.655275 972.7869803 1100.52357 1.131309929 0.177994218 0.468877114 1 9.826964458 10.93130879 55623 THUMP domain containing 1 "GO:0000154,GO:0003723,GO:0005515,GO:0005654,GO:0006400" rRNA modification|RNA binding|protein binding|nucleoplasm|tRNA modification THUMPD2 195.1083999 214.3252598 175.8915399 0.820675734 -0.285115799 0.44125942 1 3.834443582 3.094176782 80745 THUMP domain containing 2 "GO:0003723,GO:0005515,GO:0016423,GO:0030488" RNA binding|protein binding|tRNA (guanine) methyltransferase activity|tRNA methylation THUMPD3 1003.510486 935.3320805 1071.688891 1.145784383 0.196335579 0.425402529 1 11.16460614 12.5781707 25917 THUMP domain containing 3 "GO:0003723,GO:0005515,GO:0005730,GO:0005829,GO:0016423,GO:0030488" RNA binding|protein binding|nucleolus|cytosol|tRNA (guanine) methyltransferase activity|tRNA methylation THYN1 671.3442417 554.5405994 788.1478839 1.421262726 0.507173267 0.049271158 1 22.69540843 31.71637526 29087 thymocyte nuclear protein 1 GO:0005634 nucleus TIA1 1205.975396 1279.709076 1132.241716 0.884764934 -0.176633886 0.466485131 1 12.50608338 10.87978719 7072 TIA1 cytotoxic granule associated RNA binding protein "GO:0001818,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0008143,GO:0008543,GO:0010494,GO:0017148,GO:0035925,GO:0048024,GO:0097165,GO:1903608,GO:1904037,GO:1990904" "negative regulation of cytokine production|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|apoptotic process|poly(A) binding|fibroblast growth factor receptor signaling pathway|cytoplasmic stress granule|negative regulation of translation|mRNA 3'-UTR AU-rich region binding|regulation of mRNA splicing, via spliceosome|nuclear stress granule|protein localization to cytoplasmic stress granule|positive regulation of epithelial cell apoptotic process|ribonucleoprotein complex" TIAF1 6.524916457 7.282897178 5.766935736 0.791846376 -0.336707531 0.922510643 1 0.186057844 0.144863875 9220 TGFB1-induced anti-apoptotic factor 1 "GO:0003674,GO:0005515,GO:0005634,GO:0006915,GO:0007249,GO:0042802,GO:0043066" molecular_function|protein binding|nucleus|apoptotic process|I-kappaB kinase/NF-kappaB signaling|identical protein binding|negative regulation of apoptotic process TIAL1 1432.213153 1365.023014 1499.403291 1.09844543 0.135463199 0.572531063 1 17.46554051 18.86390911 7073 TIA1 cytotoxic granule associated RNA binding protein like 1 "GO:0003677,GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0006357,GO:0006915,GO:0006952,GO:0008543,GO:0010494,GO:1990904" DNA binding|RNA binding|nucleus|nucleoplasm|cytoplasm|lysosome|regulation of transcription by RNA polymerase II|apoptotic process|defense response|fibroblast growth factor receptor signaling pathway|cytoplasmic stress granule|ribonucleoprotein complex TIAM1 498.1185175 498.3582498 497.8787852 0.999037912 -0.001388668 1 1 2.805534161 2.755933342 7074 TIAM Rac1 associated GEF 1 "GO:0003300,GO:0005085,GO:0005515,GO:0005634,GO:0005829,GO:0005874,GO:0005886,GO:0005911,GO:0006915,GO:0007160,GO:0007186,GO:0007264,GO:0008017,GO:0008284,GO:0008289,GO:0010717,GO:0010718,GO:0016020,GO:0016477,GO:0016601,GO:0019900,GO:0030335,GO:0030971,GO:0031234,GO:0032092,GO:0032587,GO:0034622,GO:0042220,GO:0043025,GO:0043065,GO:0043197,GO:0043507,GO:0044291,GO:0044295,GO:0044304,GO:0045202,GO:0048013,GO:0050772,GO:0051056,GO:0060071,GO:0061003,GO:0061178,GO:0070372,GO:0072657,GO:0090630,GO:0098978,GO:0098989,GO:0099147,GO:1904268,GO:1904338,GO:1905274,GO:1990138,GO:2000050" "cardiac muscle hypertrophy|guanyl-nucleotide exchange factor activity|protein binding|nucleus|cytosol|microtubule|plasma membrane|cell-cell junction|apoptotic process|cell-matrix adhesion|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|microtubule binding|positive regulation of cell population proliferation|lipid binding|regulation of epithelial to mesenchymal transition|positive regulation of epithelial to mesenchymal transition|membrane|cell migration|Rac protein signal transduction|kinase binding|positive regulation of cell migration|receptor tyrosine kinase binding|extrinsic component of cytoplasmic side of plasma membrane|positive regulation of protein binding|ruffle membrane|cellular protein-containing complex assembly|response to cocaine|neuronal cell body|positive regulation of apoptotic process|dendritic spine|positive regulation of JUN kinase activity|cell-cell contact zone|axonal growth cone|main axon|synapse|ephrin receptor signaling pathway|positive regulation of axonogenesis|regulation of small GTPase mediated signal transduction|Wnt signaling pathway, planar cell polarity pathway|positive regulation of dendritic spine morphogenesis|regulation of insulin secretion involved in cellular response to glucose stimulus|regulation of ERK1 and ERK2 cascade|protein localization to membrane|activation of GTPase activity|glutamatergic synapse|NMDA selective glutamate receptor signaling pathway|extrinsic component of postsynaptic density membrane|positive regulation of Schwann cell chemotaxis|regulation of dopaminergic neuron differentiation|regulation of modification of postsynaptic actin cytoskeleton|neuron projection extension|regulation of non-canonical Wnt signaling pathway" "hsa04014,hsa04015,hsa04024,hsa04062,hsa04530,hsa04810,hsa05205" Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Tight junction|Regulation of actin cytoskeleton|Proteoglycans in cancer TIAM2 21.93297988 33.29324424 10.57271552 0.31756339 -1.654883491 0.047101113 1 0.275216737 0.08593626 26230 TIAM Rac1 associated GEF 2 "GO:0005096,GO:0005829,GO:0007186,GO:0007264,GO:0016020,GO:0019216,GO:0030027,GO:0030175,GO:0030426,GO:0043065,GO:0043204,GO:0045202,GO:0050772,GO:0051056,GO:0070062,GO:0090630" GTPase activator activity|cytosol|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|membrane|regulation of lipid metabolic process|lamellipodium|filopodium|growth cone|positive regulation of apoptotic process|perikaryon|synapse|positive regulation of axonogenesis|regulation of small GTPase mediated signal transduction|extracellular exosome|activation of GTPase activity TICAM1 521.8448616 553.5001856 490.1895376 0.885617657 -0.175244109 0.520227955 1 11.00569583 9.583738414 148022 toll like receptor adaptor molecule 1 "GO:0002281,GO:0002735,GO:0002756,GO:0005515,GO:0005739,GO:0005776,GO:0005829,GO:0006954,GO:0007249,GO:0010008,GO:0010508,GO:0010628,GO:0016032,GO:0019901,GO:0030890,GO:0031398,GO:0031663,GO:0032092,GO:0032722,GO:0032728,GO:0032755,GO:0032760,GO:0032816,GO:0034128,GO:0034138,GO:0035666,GO:0043123,GO:0043254,GO:0043330,GO:0045087,GO:0045429,GO:0051092,GO:0051607,GO:0070266,GO:0071222,GO:0097190,GO:0097342,GO:0140052,GO:1900017" macrophage activation involved in immune response|positive regulation of myeloid dendritic cell cytokine production|MyD88-independent toll-like receptor signaling pathway|protein binding|mitochondrion|autophagosome|cytosol|inflammatory response|I-kappaB kinase/NF-kappaB signaling|endosome membrane|positive regulation of autophagy|positive regulation of gene expression|viral process|protein kinase binding|positive regulation of B cell proliferation|positive regulation of protein ubiquitination|lipopolysaccharide-mediated signaling pathway|positive regulation of protein binding|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of natural killer cell activation|negative regulation of MyD88-independent toll-like receptor signaling pathway|toll-like receptor 3 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|regulation of protein-containing complex assembly|response to exogenous dsRNA|innate immune response|positive regulation of nitric oxide biosynthetic process|positive regulation of NF-kappaB transcription factor activity|defense response to virus|necroptotic process|cellular response to lipopolysaccharide|apoptotic signaling pathway|ripoptosome|cellular response to oxidised low-density lipoprotein particle stimulus|positive regulation of cytokine production involved in inflammatory response "hsa04064,hsa04217,hsa04620,hsa04621,hsa05133,hsa05135,hsa05142,hsa05160,hsa05161,hsa05164,hsa05165,hsa05167,hsa05168,hsa05235" NF-kappa B signaling pathway|Necroptosis|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Pertussis|Yersinia infection|Chagas disease|Hepatitis C|Hepatitis B|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer TICAM2 8.967435311 8.323311061 9.61155956 1.154775965 0.207612985 0.965671908 1 0.138682427 0.157467288 353376 toll like receptor adaptor molecule 2 "GO:0001891,GO:0002756,GO:0005515,GO:0005783,GO:0005793,GO:0005794,GO:0005886,GO:0006886,GO:0006888,GO:0006909,GO:0006954,GO:0007030,GO:0007249,GO:0010008,GO:0030134,GO:0030667,GO:0031901,GO:0031902,GO:0034128,GO:0034142,GO:0034145,GO:0035666,GO:0035669,GO:0042995,GO:0043123,GO:0043312,GO:0045087,GO:0070266,GO:0071222,GO:0097190,GO:2000494" phagocytic cup|MyD88-independent toll-like receptor signaling pathway|protein binding|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|plasma membrane|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|phagocytosis|inflammatory response|Golgi organization|I-kappaB kinase/NF-kappaB signaling|endosome membrane|COPII-coated ER to Golgi transport vesicle|secretory granule membrane|early endosome membrane|late endosome membrane|negative regulation of MyD88-independent toll-like receptor signaling pathway|toll-like receptor 4 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|TRAM-dependent toll-like receptor 4 signaling pathway|cell projection|positive regulation of I-kappaB kinase/NF-kappaB signaling|neutrophil degranulation|innate immune response|necroptotic process|cellular response to lipopolysaccharide|apoptotic signaling pathway|positive regulation of interleukin-18-mediated signaling pathway "hsa04064,hsa04217,hsa04620,hsa05133,hsa05161,hsa05235" NF-kappa B signaling pathway|Necroptosis|Toll-like receptor signaling pathway|Pertussis|Hepatitis B|PD-L1 expression and PD-1 checkpoint pathway in cancer TICRR 688.6633274 807.3611729 569.9654819 0.705960976 -0.502339658 0.050395211 1 6.34758131 4.406158811 90381 TOPBP1 interacting checkpoint and replication regulator "GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006260,GO:0006281,GO:0007093,GO:0007095,GO:0010212,GO:0030174,GO:0033314,GO:0043231" chromatin binding|protein binding|nucleus|nucleoplasm|cytosol|DNA replication|DNA repair|mitotic cell cycle checkpoint|mitotic G2 DNA damage checkpoint|response to ionizing radiation|regulation of DNA-dependent DNA replication initiation|mitotic DNA replication checkpoint|intracellular membrane-bounded organelle TIE1 119.8960455 119.6475965 120.1444945 1.004153013 0.005979124 1 1 1.256221193 1.240329834 7075 tyrosine kinase with immunoglobulin like and EGF like domains 1 "GO:0001525,GO:0001570,GO:0001701,GO:0001936,GO:0003180,GO:0004714,GO:0005515,GO:0005524,GO:0005887,GO:0007165,GO:0007169,GO:0007275,GO:0007498,GO:0016525,GO:0018108,GO:0030336,GO:0032526,GO:0033674,GO:0043235,GO:0045026,GO:0045766,GO:0048771,GO:0060836,GO:0060854,GO:1901201" angiogenesis|vasculogenesis|in utero embryonic development|regulation of endothelial cell proliferation|aortic valve morphogenesis|transmembrane receptor protein tyrosine kinase activity|protein binding|ATP binding|integral component of plasma membrane|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|mesoderm development|negative regulation of angiogenesis|peptidyl-tyrosine phosphorylation|negative regulation of cell migration|response to retinoic acid|positive regulation of kinase activity|receptor complex|plasma membrane fusion|positive regulation of angiogenesis|tissue remodeling|lymphatic endothelial cell differentiation|branching involved in lymph vessel morphogenesis|regulation of extracellular matrix assembly TIFA 521.6020574 559.7426689 483.4614459 0.863720907 -0.211362883 0.436905303 1 7.175699609 6.094089959 92610 TRAF interacting protein with forkhead associated domain "GO:0002753,GO:0005515,GO:0005737,GO:0007249,GO:0043123,GO:0045087,GO:0051260" cytoplasmic pattern recognition receptor signaling pathway|protein binding|cytoplasm|I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|protein homooligomerization hsa05131 Shigellosis TIGAR 389.0725903 385.9935505 392.15163 1.015953841 0.022834855 0.947116619 1 2.509412396 2.506785616 57103 TP53 induced glycolysis regulatory phosphatase "GO:0002931,GO:0004083,GO:0004331,GO:0005515,GO:0005634,GO:0005737,GO:0005741,GO:0005829,GO:0006003,GO:0006914,GO:0006915,GO:0006974,GO:0009410,GO:0010332,GO:0010666,GO:0016311,GO:0030388,GO:0043069,GO:0043456,GO:0045739,GO:0045820,GO:0060576,GO:0071279,GO:0071456,GO:1901215,GO:1901525,GO:1902153,GO:1903301,GO:1904024,GO:2000378" "response to ischemia|bisphosphoglycerate 2-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|protein binding|nucleus|cytoplasm|mitochondrial outer membrane|cytosol|fructose 2,6-bisphosphate metabolic process|autophagy|apoptotic process|cellular response to DNA damage stimulus|response to xenobiotic stimulus|response to gamma radiation|positive regulation of cardiac muscle cell apoptotic process|dephosphorylation|fructose 1,6-bisphosphate metabolic process|negative regulation of programmed cell death|regulation of pentose-phosphate shunt|positive regulation of DNA repair|negative regulation of glycolytic process|intestinal epithelial cell development|cellular response to cobalt ion|cellular response to hypoxia|negative regulation of neuron death|negative regulation of mitophagy|regulation of response to DNA damage checkpoint signaling|positive regulation of hexokinase activity|negative regulation of glucose catabolic process to lactate via pyruvate|negative regulation of reactive oxygen species metabolic process" "hsa00051,hsa05230" Fructose and mannose metabolism|Central carbon metabolism in cancer TIGD1 155.6915592 138.3750464 173.0080721 1.250283751 0.322255551 0.425318503 1 1.10634036 1.360092738 200765 tigger transposable element derived 1 "GO:0003677,GO:0005515,GO:0005634" DNA binding|protein binding|nucleus TIGD2 420.1214605 456.7416945 383.5012264 0.839645758 -0.252147303 0.378697218 1 7.192524278 5.938115129 166815 tigger transposable element derived 2 "GO:0003677,GO:0005634" DNA binding|nucleus TIGD3 8.967435311 8.323311061 9.61155956 1.154775965 0.207612985 0.965671908 1 0.219033439 0.248702033 220359 tigger transposable element derived 3 "GO:0003677,GO:0005515,GO:0005634" DNA binding|protein binding|nucleus TIGD4 16.49313669 16.64662212 16.33965125 0.98155957 -0.026852269 1 1 0.280694985 0.270908414 201798 tigger transposable element derived 4 "GO:0003677,GO:0005515,GO:0005634" DNA binding|protein binding|nucleus TIGD5 171.0103039 187.2744989 154.7461089 0.826306357 -0.275251328 0.481126357 1 1.852891325 1.505435734 84948 tigger transposable element derived 5 "GO:0003674,GO:0003677,GO:0005575,GO:0005634,GO:0008150" molecular_function|DNA binding|cellular_component|nucleus|biological_process TIGD6 71.53127683 86.35435226 56.7082014 0.656691874 -0.606711492 0.251140306 1 1.141018338 0.736758992 81789 tigger transposable element derived 6 "GO:0003677,GO:0005634" DNA binding|nucleus TIGD7 103.3236509 100.9201466 105.7271552 1.047631803 0.067131761 0.906067664 1 1.574370869 1.621761169 91151 tigger transposable element derived 7 "GO:0003677,GO:0005515,GO:0005634" DNA binding|protein binding|nucleus TIMELESS 1852.814577 1922.684855 1782.944298 0.927320093 -0.10886068 0.647142215 1 19.89339996 18.13885474 8914 timeless circadian regulator "GO:0000076,GO:0000122,GO:0000785,GO:0002009,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006260,GO:0006281,GO:0006974,GO:0007623,GO:0009582,GO:0030324,GO:0031298,GO:0035861,GO:0042127,GO:0042752,GO:0043111,GO:0044770,GO:0045892,GO:0048478,GO:0048754,GO:0051301,GO:0072711,GO:0072719,GO:1904976,GO:1905168,GO:2000781" "DNA replication checkpoint|negative regulation of transcription by RNA polymerase II|chromatin|morphogenesis of an epithelium|DNA binding|protein binding|nucleus|nucleoplasm|DNA replication|DNA repair|cellular response to DNA damage stimulus|circadian rhythm|detection of abiotic stimulus|lung development|replication fork protection complex|site of double-strand break|regulation of cell population proliferation|regulation of circadian rhythm|replication fork arrest|cell cycle phase transition|negative regulation of transcription, DNA-templated|replication fork protection|branching morphogenesis of an epithelial tube|cell division|cellular response to hydroxyurea|cellular response to cisplatin|cellular response to bleomycin|positive regulation of double-strand break repair via homologous recombination|positive regulation of double-strand break repair" TIMM10 324.7298614 349.5790646 299.8806583 0.857833574 -0.221230314 0.474757277 1 11.33438164 9.560311651 26519 translocase of inner mitochondrial membrane 10 "GO:0005515,GO:0005739,GO:0005743,GO:0005744,GO:0005758,GO:0006626,GO:0007605,GO:0008270,GO:0042719,GO:0042803,GO:0045039,GO:0051087,GO:0072321,GO:0140318" protein binding|mitochondrion|mitochondrial inner membrane|TIM23 mitochondrial import inner membrane translocase complex|mitochondrial intermembrane space|protein targeting to mitochondrion|sensory perception of sound|zinc ion binding|mitochondrial intermembrane space protein transporter complex|protein homodimerization activity|protein insertion into mitochondrial inner membrane|chaperone binding|chaperone-mediated protein transport|protein transporter activity TIMM10B 434.9797488 455.7012806 414.258217 0.909056513 -0.13755811 0.631499652 1 8.723077404 7.797076359 26515 translocase of inner mitochondrial membrane 10B "GO:0005515,GO:0005743,GO:0005758,GO:0006626,GO:0007160,GO:0042719,GO:0042721,GO:0045039,GO:0046872,GO:0140318" protein binding|mitochondrial inner membrane|mitochondrial intermembrane space|protein targeting to mitochondrion|cell-matrix adhesion|mitochondrial intermembrane space protein transporter complex|TIM22 mitochondrial import inner membrane insertion complex|protein insertion into mitochondrial inner membrane|metal ion binding|protein transporter activity TIMM13 402.280939 404.7210003 399.8408777 0.987942008 -0.017501737 0.961130145 1 12.98029804 12.60919309 26517 translocase of inner mitochondrial membrane 13 "GO:0001650,GO:0005515,GO:0005739,GO:0005743,GO:0006626,GO:0007605,GO:0008270,GO:0042719,GO:0045039,GO:0072321" fibrillar center|protein binding|mitochondrion|mitochondrial inner membrane|protein targeting to mitochondrion|sensory perception of sound|zinc ion binding|mitochondrial intermembrane space protein transporter complex|protein insertion into mitochondrial inner membrane|chaperone-mediated protein transport TIMM17A 935.7691125 885.3922141 986.1460108 1.113795666 0.155484584 0.53145878 1 28.63742739 31.36250209 10440 translocase of inner mitochondrial membrane 17A "GO:0005654,GO:0005739,GO:0005743,GO:0005744,GO:0006626,GO:0008320,GO:0010954,GO:0030150,GO:0031305" nucleoplasm|mitochondrion|mitochondrial inner membrane|TIM23 mitochondrial import inner membrane translocase complex|protein targeting to mitochondrion|protein transmembrane transporter activity|positive regulation of protein processing|protein import into mitochondrial matrix|integral component of mitochondrial inner membrane TIMM17B 713.1142824 654.4203322 771.8082327 1.179376915 0.238024861 0.352597572 1 31.75019123 36.81884382 10245 translocase of inner mitochondrial membrane 17B "GO:0005515,GO:0005743,GO:0005744,GO:0006626,GO:0008320,GO:0030150,GO:0031305" protein binding|mitochondrial inner membrane|TIM23 mitochondrial import inner membrane translocase complex|protein targeting to mitochondrion|protein transmembrane transporter activity|protein import into mitochondrial matrix|integral component of mitochondrial inner membrane TIMM21 441.8367882 433.8525891 449.8209874 1.036806046 0.052146036 0.860861002 1 7.49317647 7.638967464 29090 translocase of inner mitochondrial membrane 21 "GO:0003674,GO:0005515,GO:0005744,GO:0016021,GO:0030150,GO:0032981,GO:0033617" molecular_function|protein binding|TIM23 mitochondrial import inner membrane translocase complex|integral component of membrane|protein import into mitochondrial matrix|mitochondrial respiratory chain complex I assembly|mitochondrial cytochrome c oxidase assembly TIMM22 400.517143 408.8826559 392.15163 0.959081107 -0.06027527 0.842851847 1 6.857735968 6.467065721 29928 translocase of inner mitochondrial membrane 22 "GO:0005515,GO:0005743,GO:0006626,GO:0008320,GO:0016021,GO:0030943,GO:0042721,GO:0045039,GO:0071806,GO:0140318" protein binding|mitochondrial inner membrane|protein targeting to mitochondrion|protein transmembrane transporter activity|integral component of membrane|mitochondrion targeting sequence binding|TIM22 mitochondrial import inner membrane insertion complex|protein insertion into mitochondrial inner membrane|protein transmembrane transport|protein transporter activity TIMM23 1390.606658 1256.81997 1524.393346 1.212897139 0.278457206 0.245367977 1 56.36485031 67.22077392 100287932 translocase of inner mitochondrial membrane 23 "GO:0005515,GO:0005739,GO:0005743,GO:0005744,GO:0005758,GO:0006626,GO:0008320,GO:0030150,GO:0031305" protein binding|mitochondrion|mitochondrial inner membrane|TIM23 mitochondrial import inner membrane translocase complex|mitochondrial intermembrane space|protein targeting to mitochondrion|protein transmembrane transporter activity|protein import into mitochondrial matrix|integral component of mitochondrial inner membrane TIMM23B 301.2066926 287.1542316 315.2591536 1.097873961 0.134712438 0.675315831 1 6.142241913 6.630565665 100652748 translocase of inner mitochondrial membrane 23 homolog B "GO:0003674,GO:0005575,GO:0005744,GO:0008150,GO:0008320,GO:0030150,GO:0031305" molecular_function|cellular_component|TIM23 mitochondrial import inner membrane translocase complex|biological_process|protein transmembrane transporter activity|protein import into mitochondrial matrix|integral component of mitochondrial inner membrane TIMM29 174.3051527 160.2237379 188.3865674 1.175771891 0.233608194 0.549270973 1 6.348067123 7.338980982 90580 translocase of inner mitochondrial membrane 29 "GO:0005515,GO:0005743,GO:0005758,GO:0016021,GO:0042721,GO:0045039,GO:0140318" protein binding|mitochondrial inner membrane|mitochondrial intermembrane space|integral component of membrane|TIM22 mitochondrial import inner membrane insertion complex|protein insertion into mitochondrial inner membrane|protein transporter activity TIMM44 407.4628868 465.0650055 349.860768 0.752283581 -0.410651491 0.153407429 1 13.4669911 9.961467791 10469 translocase of inner mitochondrial membrane 44 "GO:0001650,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0005759,GO:0006626,GO:0030150,GO:0051087" fibrillar center|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|protein targeting to mitochondrion|protein import into mitochondrial matrix|chaperone binding TIMM50 679.1517618 658.5819877 699.721536 1.062466859 0.087417841 0.738528488 1 23.49419135 24.54409778 92609 translocase of inner mitochondrial membrane 50 "GO:0001836,GO:0003723,GO:0004721,GO:0004722,GO:0004725,GO:0005134,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005744,GO:0006470,GO:0007006,GO:0016021,GO:0016607,GO:0030150,GO:0035335,GO:0043021" release of cytochrome c from mitochondria|RNA binding|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|interleukin-2 receptor binding|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|TIM23 mitochondrial import inner membrane translocase complex|protein dephosphorylation|mitochondrial membrane organization|integral component of membrane|nuclear speck|protein import into mitochondrial matrix|peptidyl-tyrosine dephosphorylation|ribonucleoprotein complex binding TIMM8A 464.3396649 444.2567279 484.4226018 1.090411403 0.124872554 0.65854187 1 8.034281619 8.614074304 1678 translocase of inner mitochondrial membrane 8A "GO:0005515,GO:0005739,GO:0005743,GO:0005758,GO:0007399,GO:0042802,GO:0046872,GO:0072321" protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|nervous system development|identical protein binding|metal ion binding|chaperone-mediated protein transport TIMM8B 323.5806215 319.407062 327.754181 1.02613317 0.037217974 0.914093996 1 21.85406135 22.04992228 26521 translocase of inner mitochondrial membrane 8 homolog B "GO:0005615,GO:0005743,GO:0006626,GO:0007605,GO:0008270,GO:0042719,GO:0045039,GO:0072321,GO:0140318" extracellular space|mitochondrial inner membrane|protein targeting to mitochondrion|sensory perception of sound|zinc ion binding|mitochondrial intermembrane space protein transporter complex|protein insertion into mitochondrial inner membrane|chaperone-mediated protein transport|protein transporter activity TIMM9 493.1888204 507.7219747 478.6556661 0.942751525 -0.085050515 0.762326935 1 21.62505079 20.04589995 26520 translocase of inner mitochondrial membrane 9 "GO:0005515,GO:0005739,GO:0005743,GO:0005758,GO:0006626,GO:0007605,GO:0008270,GO:0042719,GO:0042803,GO:0045039,GO:0051087,GO:0072321,GO:0140318" protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|protein targeting to mitochondrion|sensory perception of sound|zinc ion binding|mitochondrial intermembrane space protein transporter complex|protein homodimerization activity|protein insertion into mitochondrial inner membrane|chaperone binding|chaperone-mediated protein transport|protein transporter activity TIMMDC1 1208.244922 1213.122587 1203.367257 0.991958496 -0.011648336 0.965372652 1 26.96464925 26.30022449 51300 translocase of inner mitochondrial membrane domain containing 1 "GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0016021,GO:0032981" protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|integral component of membrane|mitochondrial respiratory chain complex I assembly TIMP1 5541.510028 4061.775798 7021.244259 1.728614431 0.78961611 0.001126198 0.210969289 271.9818182 462.2843439 7076 TIMP metallopeptidase inhibitor 1 "GO:0001775,GO:0002020,GO:0002248,GO:0002576,GO:0005125,GO:0005515,GO:0005576,GO:0005604,GO:0005615,GO:0005788,GO:0007568,GO:0008083,GO:0008191,GO:0008270,GO:0008284,GO:0009725,GO:0010033,GO:0010951,GO:0019221,GO:0022617,GO:0030414,GO:0031012,GO:0031093,GO:0034097,GO:0043066,GO:0043086,GO:0043434,GO:0043687,GO:0044267,GO:0051045,GO:0051216,GO:0070062,GO:0071492,GO:1901164,GO:1905049,GO:2001044" cell activation|protease binding|connective tissue replacement involved in inflammatory response wound healing|platelet degranulation|cytokine activity|protein binding|extracellular region|basement membrane|extracellular space|endoplasmic reticulum lumen|aging|growth factor activity|metalloendopeptidase inhibitor activity|zinc ion binding|positive regulation of cell population proliferation|response to hormone|response to organic substance|negative regulation of endopeptidase activity|cytokine-mediated signaling pathway|extracellular matrix disassembly|peptidase inhibitor activity|extracellular matrix|platelet alpha granule lumen|response to cytokine|negative regulation of apoptotic process|negative regulation of catalytic activity|response to peptide hormone|post-translational protein modification|cellular protein metabolic process|negative regulation of membrane protein ectodomain proteolysis|cartilage development|extracellular exosome|cellular response to UV-A|negative regulation of trophoblast cell migration|negative regulation of metallopeptidase activity|regulation of integrin-mediated signaling pathway hsa04066 HIF-1 signaling pathway TIMP2 10782.03774 10857.75928 10706.31619 0.986052087 -0.020264238 0.936539296 1 158.6688546 153.83768 7077 TIMP metallopeptidase inhibitor 2 "GO:0002020,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0007417,GO:0007568,GO:0008191,GO:0008270,GO:0008285,GO:0009725,GO:0009986,GO:0010033,GO:0010951,GO:0022617,GO:0030414,GO:0030426,GO:0031012,GO:0032487,GO:0034097,GO:0035580,GO:0042493,GO:0043025,GO:0043312,GO:0043410,GO:0045666,GO:0045762,GO:0045930,GO:0046580,GO:0051045,GO:0062023,GO:1904724,GO:1904813,GO:1905049" protease binding|integrin binding|protein binding|extracellular region|extracellular space|central nervous system development|aging|metalloendopeptidase inhibitor activity|zinc ion binding|negative regulation of cell population proliferation|response to hormone|cell surface|response to organic substance|negative regulation of endopeptidase activity|extracellular matrix disassembly|peptidase inhibitor activity|growth cone|extracellular matrix|regulation of Rap protein signal transduction|response to cytokine|specific granule lumen|response to drug|neuronal cell body|neutrophil degranulation|positive regulation of MAPK cascade|positive regulation of neuron differentiation|positive regulation of adenylate cyclase activity|negative regulation of mitotic cell cycle|negative regulation of Ras protein signal transduction|negative regulation of membrane protein ectodomain proteolysis|collagen-containing extracellular matrix|tertiary granule lumen|ficolin-1-rich granule lumen|negative regulation of metallopeptidase activity TIMP4 117.5969512 160.2237379 74.97016457 0.467909222 -1.095699432 0.013551401 0.688904876 7.16151291 3.294864526 7079 TIMP metallopeptidase inhibitor 4 "GO:0002020,GO:0005615,GO:0007219,GO:0007417,GO:0008150,GO:0008191,GO:0009725,GO:0010033,GO:0010951,GO:0030017,GO:0031012,GO:0032496,GO:0034097,GO:0042493,GO:0042698,GO:0043434,GO:0046872,GO:0051045" protease binding|extracellular space|Notch signaling pathway|central nervous system development|biological_process|metalloendopeptidase inhibitor activity|response to hormone|response to organic substance|negative regulation of endopeptidase activity|sarcomere|extracellular matrix|response to lipopolysaccharide|response to cytokine|response to drug|ovulation cycle|response to peptide hormone|metal ion binding|negative regulation of membrane protein ectodomain proteolysis TINAGL1 6191.900955 6425.596139 5958.205771 0.927261166 -0.108952359 0.653611209 1 143.9640034 131.2584181 64129 tubulointerstitial nephritis antigen like 1 "GO:0005201,GO:0005515,GO:0005576,GO:0005615,GO:0005764,GO:0006508,GO:0008234,GO:0016197,GO:0043236,GO:0062023,GO:0070062" extracellular matrix structural constituent|protein binding|extracellular region|extracellular space|lysosome|proteolysis|cysteine-type peptidase activity|endosomal transport|laminin binding|collagen-containing extracellular matrix|extracellular exosome TINF2 1308.417763 1281.789903 1335.045623 1.041547932 0.058729233 0.809844224 1 31.80231116 32.56935231 26277 TERF1 interacting nuclear factor 2 "GO:0000781,GO:0000783,GO:0003677,GO:0005515,GO:0005654,GO:0010370,GO:0010836,GO:0016233,GO:0016363,GO:0016604,GO:0032202,GO:0032211,GO:0042162,GO:0050680,GO:0070187,GO:0070198,GO:1904356" "chromosome, telomeric region|nuclear telomere cap complex|DNA binding|protein binding|nucleoplasm|perinucleolar chromocenter|negative regulation of protein ADP-ribosylation|telomere capping|nuclear matrix|nuclear body|telomere assembly|negative regulation of telomere maintenance via telomerase|telomeric DNA binding|negative regulation of epithelial cell proliferation|shelterin complex|protein localization to chromosome, telomeric region|regulation of telomere maintenance via telomere lengthening" TIPARP 1285.557611 1362.942186 1208.173037 0.886444817 -0.173897272 0.471218789 1 16.69061944 14.54773356 25976 TCDD inducible poly(ADP-ribose) polymerase "GO:0000987,GO:0001570,GO:0001822,GO:0003950,GO:0005634,GO:0006471,GO:0008209,GO:0008210,GO:0008585,GO:0009791,GO:0010629,GO:0030097,GO:0045732,GO:0046872,GO:0048008,GO:0048705,GO:0048745,GO:0060021,GO:0060325,GO:0070213,GO:0071407,GO:0140289,GO:1904612,GO:1990404" "cis-regulatory region sequence-specific DNA binding|vasculogenesis|kidney development|NAD+ ADP-ribosyltransferase activity|nucleus|protein ADP-ribosylation|androgen metabolic process|estrogen metabolic process|female gonad development|post-embryonic development|negative regulation of gene expression|hemopoiesis|positive regulation of protein catabolic process|metal ion binding|platelet-derived growth factor receptor signaling pathway|skeletal system morphogenesis|smooth muscle tissue development|roof of mouth development|face morphogenesis|protein auto-ADP-ribosylation|cellular response to organic cyclic compound|protein mono-ADP-ribosylation|response to 2,3,7,8-tetrachlorodibenzodioxine|protein ADP-ribosylase activity" TIPIN 249.6414243 245.5376763 253.7451724 1.033426626 0.04743596 0.899632125 1 3.666450617 3.725603778 54962 TIMELESS interacting protein "GO:0000076,GO:0000785,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006260,GO:0008284,GO:0009411,GO:0031298,GO:0031573,GO:0033262,GO:0043111,GO:0044770,GO:0048478,GO:0051301" DNA replication checkpoint|chromatin|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|DNA replication|positive regulation of cell population proliferation|response to UV|replication fork protection complex|intra-S DNA damage checkpoint|regulation of nuclear cell cycle DNA replication|replication fork arrest|cell cycle phase transition|replication fork protection|cell division TIPRL 1292.251105 1349.416806 1235.085403 0.915273471 -0.12772523 0.597330566 1 22.60385901 20.3425149 261726 TOR signaling pathway regulator "GO:0000077,GO:0005515,GO:0005829,GO:0031929,GO:0032515,GO:0043666" DNA damage checkpoint|protein binding|cytosol|TOR signaling|negative regulation of phosphoprotein phosphatase activity|regulation of phosphoprotein phosphatase activity TIRAP 192.5469941 210.1636043 174.930384 0.832353369 -0.264731952 0.477766012 1 4.524423274 3.7029014 114609 TIR domain containing adaptor protein "GO:0002755,GO:0005080,GO:0005515,GO:0005546,GO:0005737,GO:0005829,GO:0005886,GO:0006954,GO:0007166,GO:0007250,GO:0030099,GO:0030139,GO:0030674,GO:0030890,GO:0031334,GO:0032496,GO:0032587,GO:0032648,GO:0032735,GO:0032738,GO:0032755,GO:0032757,GO:0032760,GO:0034137,GO:0034141,GO:0034145,GO:0035662,GO:0035663,GO:0035665,GO:0042802,GO:0043123,GO:0045087,GO:0045088,GO:0046330,GO:0050830,GO:0051092,GO:0070374,GO:0070935,GO:0071221,GO:0071223,GO:0090023,GO:2000340,GO:2000343" "MyD88-dependent toll-like receptor signaling pathway|protein kinase C binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|cytosol|plasma membrane|inflammatory response|cell surface receptor signaling pathway|activation of NF-kappaB-inducing kinase activity|myeloid cell differentiation|endocytic vesicle|protein-macromolecule adaptor activity|positive regulation of B cell proliferation|positive regulation of protein-containing complex assembly|response to lipopolysaccharide|ruffle membrane|regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-15 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|positive regulation of toll-like receptor 2 signaling pathway|positive regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|Toll-like receptor 4 binding|Toll-like receptor 2 binding|TIRAP-dependent toll-like receptor 4 signaling pathway|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|regulation of innate immune response|positive regulation of JNK cascade|defense response to Gram-positive bacterium|positive regulation of NF-kappaB transcription factor activity|positive regulation of ERK1 and ERK2 cascade|3'-UTR-mediated mRNA stabilization|cellular response to bacterial lipopeptide|cellular response to lipoteichoic acid|positive regulation of neutrophil chemotaxis|positive regulation of chemokine (C-X-C motif) ligand 1 production|positive regulation of chemokine (C-X-C motif) ligand 2 production" "hsa04064,hsa04620,hsa05130,hsa05132,hsa05133,hsa05152,hsa05161,hsa05235" NF-kappa B signaling pathway|Toll-like receptor signaling pathway|Pathogenic Escherichia coli infection|Salmonella infection|Pertussis|Tuberculosis|Hepatitis B|PD-L1 expression and PD-1 checkpoint pathway in cancer TJAP1 533.2497853 575.3488771 491.1506935 0.853657169 -0.228271299 0.398349063 1 9.084411871 7.625204342 93643 tight junction associated protein 1 "GO:0005515,GO:0005794,GO:0005802,GO:0005923,GO:0007030" protein binding|Golgi apparatus|trans-Golgi network|bicellular tight junction|Golgi organization hsa04530 Tight junction TJP1 2005.413848 2181.747912 1829.079784 0.838355235 -0.25436641 0.282438224 1 13.33133457 10.98937232 7082 tight junction protein 1 "GO:0002102,GO:0005515,GO:0005516,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0005921,GO:0005923,GO:0007043,GO:0008284,GO:0016323,GO:0030054,GO:0030335,GO:0031032,GO:0032991,GO:0034334,GO:0035329,GO:0035633,GO:0042995,GO:0043066,GO:0043296,GO:0045177,GO:0045216,GO:0045296,GO:0050839,GO:0051493,GO:0051497,GO:0070160,GO:0071896,GO:0090557,GO:0098609,GO:0150105,GO:1901888,GO:1902396,GO:1903672,GO:1905605,GO:2000049,GO:2000250,GO:2000810" podosome|protein binding|calmodulin binding|cytoplasm|cytosol|plasma membrane|adherens junction|gap junction|bicellular tight junction|cell-cell junction assembly|positive regulation of cell population proliferation|basolateral plasma membrane|cell junction|positive regulation of cell migration|actomyosin structure organization|protein-containing complex|adherens junction maintenance|hippo signaling|maintenance of blood-brain barrier|cell projection|negative regulation of apoptotic process|apical junction complex|apical part of cell|cell-cell junction organization|cadherin binding|cell adhesion molecule binding|regulation of cytoskeleton organization|negative regulation of stress fiber assembly|tight junction|protein localization to adherens junction|establishment of endothelial intestinal barrier|cell-cell adhesion|protein localization to cell-cell junction|regulation of cell junction assembly|protein localization to bicellular tight junction|positive regulation of sprouting angiogenesis|positive regulation of blood-brain barrier permeability|positive regulation of cell-cell adhesion mediated by cadherin|negative regulation of actin cytoskeleton reorganization|regulation of bicellular tight junction assembly "hsa04520,hsa04530,hsa04540,hsa05110,hsa05120,hsa05130" Adherens junction|Tight junction|Gap junction|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection TJP2 3023.341059 3218.000139 2828.681978 0.8790186 -0.186034401 0.432221803 1 29.14778564 25.19270554 9414 tight junction protein 2 "GO:0004385,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0005912,GO:0005923,GO:0019904,GO:0030674,GO:0034109,GO:0035329,GO:0035633,GO:0044291,GO:0045216,GO:0045296,GO:0046037,GO:0046710,GO:0050839,GO:0050892,GO:0090557,GO:0090559,GO:0098609,GO:0150105,GO:1905605,GO:1990782" guanylate kinase activity|protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|adherens junction|bicellular tight junction|protein domain specific binding|protein-macromolecule adaptor activity|homotypic cell-cell adhesion|hippo signaling|maintenance of blood-brain barrier|cell-cell contact zone|cell-cell junction organization|cadherin binding|GMP metabolic process|GDP metabolic process|cell adhesion molecule binding|intestinal absorption|establishment of endothelial intestinal barrier|regulation of membrane permeability|cell-cell adhesion|protein localization to cell-cell junction|positive regulation of blood-brain barrier permeability|protein tyrosine kinase binding "hsa04530,hsa05110" Tight junction|Vibrio cholerae infection TJP3 5.484502575 5.202069413 5.766935736 1.108584926 0.148719296 1 1 0.085423041 0.093114041 27134 tight junction protein 3 "GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0005923,GO:0030054,GO:0035633,GO:0045216,GO:0050839,GO:0090557,GO:0098609,GO:0150105,GO:1905605" protein binding|nucleus|nucleoplasm|plasma membrane|bicellular tight junction|cell junction|maintenance of blood-brain barrier|cell-cell junction organization|cell adhesion molecule binding|establishment of endothelial intestinal barrier|cell-cell adhesion|protein localization to cell-cell junction|positive regulation of blood-brain barrier permeability hsa04530 Tight junction TK1 3209.782005 2977.664532 3441.899478 1.155905725 0.209023737 0.377895517 1 103.0560852 117.1297548 7083 thymidine kinase 1 "GO:0004797,GO:0005515,GO:0005524,GO:0005829,GO:0006139,GO:0008270,GO:0009157,GO:0016310,GO:0042802,GO:0043097,GO:0046104,GO:0051289,GO:0071897" thymidine kinase activity|protein binding|ATP binding|cytosol|nucleobase-containing compound metabolic process|zinc ion binding|deoxyribonucleoside monophosphate biosynthetic process|phosphorylation|identical protein binding|pyrimidine nucleoside salvage|thymidine metabolic process|protein homotetramerization|DNA biosynthetic process "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes TK2 470.5771177 469.2266611 471.9275744 1.005756095 0.008280481 0.984883734 1 4.707983549 4.655847947 7084 thymidine kinase 2 "GO:0004797,GO:0005524,GO:0005737,GO:0005759,GO:0006139,GO:0009157,GO:0009165,GO:0016310,GO:0019136,GO:0019206,GO:0043097,GO:0071897" thymidine kinase activity|ATP binding|cytoplasm|mitochondrial matrix|nucleobase-containing compound metabolic process|deoxyribonucleoside monophosphate biosynthetic process|nucleotide biosynthetic process|phosphorylation|deoxynucleoside kinase activity|nucleoside kinase activity|pyrimidine nucleoside salvage|DNA biosynthetic process "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes TKFC 708.3129187 742.8555122 673.7703252 0.907000506 -0.14082474 0.584675318 1 5.366838145 4.786270127 26007 triokinase and FMN cyclase "GO:0004371,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0019563,GO:0034012,GO:0039534,GO:0044262,GO:0045087,GO:0045088,GO:0046835,GO:0046872,GO:0050354,GO:0061624,GO:0070062" glycerone kinase activity|protein binding|ATP binding|nucleus|cytosol|glycerol catabolic process|FAD-AMP lyase (cyclizing) activity|negative regulation of MDA-5 signaling pathway|cellular carbohydrate metabolic process|innate immune response|regulation of innate immune response|carbohydrate phosphorylation|metal ion binding|triokinase activity|fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate|extracellular exosome "hsa00051,hsa00561,hsa04622" Fructose and mannose metabolism|Glycerolipid metabolism|RIG-I-like receptor signaling pathway TKT 10453.88162 10960.76025 9947.002989 0.907510315 -0.140014054 0.579061322 1 187.4257064 167.2445233 7086 transketolase "GO:0000287,GO:0004802,GO:0005509,GO:0005515,GO:0005654,GO:0005777,GO:0005789,GO:0005829,GO:0005999,GO:0006098,GO:0009052,GO:0016604,GO:0030976,GO:0031982,GO:0040008,GO:0042803,GO:0046166,GO:0046390,GO:0070062" "magnesium ion binding|transketolase activity|calcium ion binding|protein binding|nucleoplasm|peroxisome|endoplasmic reticulum membrane|cytosol|xylulose biosynthetic process|pentose-phosphate shunt|pentose-phosphate shunt, non-oxidative branch|nuclear body|thiamine pyrophosphate binding|vesicle|regulation of growth|protein homodimerization activity|glyceraldehyde-3-phosphate biosynthetic process|ribose phosphate biosynthetic process|extracellular exosome" hsa00030 Pentose phosphate pathway TKTL1 3.562190663 5.202069413 1.922311912 0.369528309 -1.436243205 0.543489417 1 0.104685099 0.038036782 8277 transketolase like 1 "GO:0004802,GO:0005634,GO:0005829,GO:0006007,GO:0006772,GO:0030976,GO:0046872" transketolase activity|nucleus|cytosol|glucose catabolic process|thiamine metabolic process|thiamine pyrophosphate binding|metal ion binding hsa00030 Pentose phosphate pathway TLCD1 86.89971129 111.3242854 62.47513714 0.561199534 -0.833414283 0.089849018 1 2.013956783 1.111318713 116238 TLC domain containing 1 "GO:0005515,GO:0005886,GO:0007009,GO:0016021,GO:0055088,GO:0055091,GO:0071709,GO:0097035" protein binding|plasma membrane|plasma membrane organization|integral component of membrane|lipid homeostasis|phospholipid homeostasis|membrane assembly|regulation of membrane lipid distribution TLCD2 132.6187859 150.860013 114.3775588 0.758170151 -0.399406437 0.349341461 1 1.36830755 1.020050291 727910 TLC domain containing 2 "GO:0005886,GO:0007009,GO:0016021,GO:0055088,GO:0055091,GO:0071709,GO:0097035" plasma membrane|plasma membrane organization|integral component of membrane|lipid homeostasis|phospholipid homeostasis|membrane assembly|regulation of membrane lipid distribution TLCD3A 654.607072 745.9767539 563.2373902 0.755033434 -0.405387564 0.117260224 1 17.90081309 13.28954524 79850 TLC domain containing 3A "GO:0005515,GO:0005783,GO:0005886,GO:0008150,GO:0016021,GO:0055088" protein binding|endoplasmic reticulum|plasma membrane|biological_process|integral component of membrane|lipid homeostasis TLCD3B 40.63589206 32.25283036 49.01895376 1.519834173 0.603913922 0.359121322 1 0.42458665 0.634503056 83723 TLC domain containing 3B "GO:0000139,GO:0005783,GO:0005789,GO:0016021,GO:0045599,GO:0046513,GO:0050291,GO:0055088" Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|negative regulation of fat cell differentiation|ceramide biosynthetic process|sphingosine N-acyltransferase activity|lipid homeostasis TLCD4 544.5766799 393.2764476 695.8769121 1.769434494 0.823288353 0.002225781 0.304375601 2.927258187 5.092918158 148534 TLC domain containing 4 "GO:0003674,GO:0005515,GO:0005575,GO:0005783,GO:0008150,GO:0016021,GO:0055088" molecular_function|protein binding|cellular_component|endoplasmic reticulum|biological_process|integral component of membrane|lipid homeostasis TLCD4-RWDD3 11.64772794 15.60620824 7.689247648 0.492704412 -1.021205706 0.35686789 1 0.558601375 0.270619838 100527978 TLCD4-RWDD3 readthrough TLCD5 661.5043548 624.2483296 698.76038 1.119362835 0.162677754 0.531700086 1 7.749473373 8.529316936 219902 TLC domain containing 5 GO:0016021 integral component of membrane TLE1 1410.378324 1485.711024 1335.045623 0.898590373 -0.15426449 0.520410883 1 24.87909217 21.98201343 7088 "TLE family member 1, transcriptional corepressor" "GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0007165,GO:0007275,GO:0008134,GO:0009887,GO:0010628,GO:0016055,GO:0030178,GO:0042802,GO:0043124,GO:0045892,GO:0070491,GO:0090090,GO:1904837,GO:1990907,GO:2000811" "transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|signal transduction|multicellular organism development|transcription factor binding|animal organ morphogenesis|positive regulation of gene expression|Wnt signaling pathway|negative regulation of Wnt signaling pathway|identical protein binding|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of transcription, DNA-templated|repressing transcription factor binding|negative regulation of canonical Wnt signaling pathway|beta-catenin-TCF complex assembly|beta-catenin-TCF complex|negative regulation of anoikis" TLE2 118.0234234 95.7180772 140.3287696 1.466063399 0.551947493 0.212739413 1 1.679808569 2.421495812 7089 "TLE family member 2, transcriptional corepressor" "GO:0003714,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005667,GO:0005925,GO:0007165,GO:0009887,GO:0016055,GO:0016604,GO:0045892,GO:0070491,GO:0090090,GO:1904837" "transcription corepressor activity|protein binding|extracellular space|nucleus|nucleoplasm|transcription regulator complex|focal adhesion|signal transduction|animal organ morphogenesis|Wnt signaling pathway|nuclear body|negative regulation of transcription, DNA-templated|repressing transcription factor binding|negative regulation of canonical Wnt signaling pathway|beta-catenin-TCF complex assembly" TLE3 295.5139844 301.720026 289.3079428 0.958862249 -0.060604523 0.8581383 1 2.553479741 2.407464079 7090 "TLE family member 3, transcriptional corepressor" "GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0007165,GO:0009887,GO:0016055,GO:0045892,GO:0070491,GO:0090090,GO:0120163,GO:1904837,GO:1990907" "transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|signal transduction|animal organ morphogenesis|Wnt signaling pathway|negative regulation of transcription, DNA-templated|repressing transcription factor binding|negative regulation of canonical Wnt signaling pathway|negative regulation of cold-induced thermogenesis|beta-catenin-TCF complex assembly|beta-catenin-TCF complex" TLE4 506.0109404 491.0753526 520.9465281 1.06082809 0.085190882 0.760464604 1 4.771993629 4.977554738 7091 "TLE family member 4, transcriptional corepressor" "GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0008150,GO:0016055,GO:0045892,GO:0070491,GO:0090090,GO:1904837,GO:1990907" "transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|biological_process|Wnt signaling pathway|negative regulation of transcription, DNA-templated|repressing transcription factor binding|negative regulation of canonical Wnt signaling pathway|beta-catenin-TCF complex assembly|beta-catenin-TCF complex" TLE5 4001.597834 3515.558509 4487.637159 1.276507601 0.352202128 0.139322081 1 90.85660839 114.0383972 166 "TLE family member 5, transcriptional modulator" "GO:0000122,GO:0001501,GO:0003714,GO:0005515,GO:0005634,GO:0005667,GO:0007275,GO:0009887,GO:0010629,GO:0016055,GO:0031668,GO:0032091,GO:0040008,GO:0045892,GO:0060761,GO:0070491,GO:0070555,GO:0090090,GO:2000210" "negative regulation of transcription by RNA polymerase II|skeletal system development|transcription corepressor activity|protein binding|nucleus|transcription regulator complex|multicellular organism development|animal organ morphogenesis|negative regulation of gene expression|Wnt signaling pathway|cellular response to extracellular stimulus|negative regulation of protein binding|regulation of growth|negative regulation of transcription, DNA-templated|negative regulation of response to cytokine stimulus|repressing transcription factor binding|response to interleukin-1|negative regulation of canonical Wnt signaling pathway|positive regulation of anoikis" TLE6 21.81912341 17.687036 25.95121081 1.467244755 0.553109551 0.525459936 1 0.317072423 0.457437976 79816 "TLE family member 6, subcortical maternal complex member" "GO:0000122,GO:0003714,GO:0005515,GO:0005634,GO:0005667,GO:0005938,GO:0007015,GO:0032991,GO:0040019,GO:0051293,GO:0051302,GO:0051643,GO:0051646,GO:0060136,GO:0070491,GO:0090090,GO:0106333" negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein binding|nucleus|transcription regulator complex|cell cortex|actin filament organization|protein-containing complex|positive regulation of embryonic development|establishment of spindle localization|regulation of cell division|endoplasmic reticulum localization|mitochondrion localization|embryonic process involved in female pregnancy|repressing transcription factor binding|negative regulation of canonical Wnt signaling pathway|subcortical maternal complex TLK1 1230.792458 1212.082173 1249.502743 1.030872964 0.043866558 0.859110793 1 10.59914761 10.74353663 9874 tousled like kinase 1 "GO:0001672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006325,GO:0006468,GO:0006886,GO:0006974,GO:0007049,GO:0007059,GO:0018105,GO:0035556,GO:0106310,GO:0106311" regulation of chromatin assembly or disassembly|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|chromatin organization|protein phosphorylation|intracellular protein transport|cellular response to DNA damage stimulus|cell cycle|chromosome segregation|peptidyl-serine phosphorylation|intracellular signal transduction|protein serine kinase activity|protein threonine kinase activity TLK2 1306.817513 1277.628248 1336.006779 1.045692893 0.064459212 0.791375128 1 9.355745254 9.619527111 11011 tousled like kinase 2 "GO:0001672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005882,GO:0006325,GO:0006468,GO:0006974,GO:0007049,GO:0007059,GO:0010507,GO:0018105,GO:0032435,GO:0035556,GO:0042802,GO:0048471,GO:0071480,GO:0106310,GO:0106311" regulation of chromatin assembly or disassembly|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|intermediate filament|chromatin organization|protein phosphorylation|cellular response to DNA damage stimulus|cell cycle|chromosome segregation|negative regulation of autophagy|peptidyl-serine phosphorylation|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|intracellular signal transduction|identical protein binding|perinuclear region of cytoplasm|cellular response to gamma radiation|protein serine kinase activity|protein threonine kinase activity TLL1 6.044338479 7.282897178 4.80577978 0.65987198 -0.599741937 0.771875613 1 0.037009602 0.024012937 7092 tolloid like 1 "GO:0001501,GO:0004222,GO:0005509,GO:0005576,GO:0006508,GO:0008270,GO:0022617,GO:0030154" skeletal system development|metalloendopeptidase activity|calcium ion binding|extracellular region|proteolysis|zinc ion binding|extracellular matrix disassembly|cell differentiation TLL2 109.0408968 124.8496659 93.23212773 0.746755124 -0.421292863 0.357002458 1 0.984339962 0.722760662 7093 tolloid like 2 "GO:0004222,GO:0005509,GO:0005576,GO:0006508,GO:0007275,GO:0008270,GO:0022617,GO:0030154,GO:0048632" metalloendopeptidase activity|calcium ion binding|extracellular region|proteolysis|multicellular organism development|zinc ion binding|extracellular matrix disassembly|cell differentiation|negative regulation of skeletal muscle tissue growth TLN1 13574.27674 13837.50464 13311.04883 0.961954426 -0.055959549 0.829380061 1 85.6409823 81.0041587 7094 talin 1 "GO:0001726,GO:0001786,GO:0002576,GO:0005178,GO:0005200,GO:0005515,GO:0005576,GO:0005829,GO:0005856,GO:0005886,GO:0005912,GO:0005925,GO:0006936,GO:0007043,GO:0007044,GO:0007229,GO:0009986,GO:0016032,GO:0017166,GO:0030274,GO:0030866,GO:0032587,GO:0033622,GO:0035091,GO:0036498,GO:0045296,GO:0051015,GO:0070062,GO:0070527,GO:0098609" ruffle|phosphatidylserine binding|platelet degranulation|integrin binding|structural constituent of cytoskeleton|protein binding|extracellular region|cytosol|cytoskeleton|plasma membrane|adherens junction|focal adhesion|muscle contraction|cell-cell junction assembly|cell-substrate junction assembly|integrin-mediated signaling pathway|cell surface|viral process|vinculin binding|LIM domain binding|cortical actin cytoskeleton organization|ruffle membrane|integrin activation|phosphatidylinositol binding|IRE1-mediated unfolded protein response|cadherin binding|actin filament binding|extracellular exosome|platelet aggregation|cell-cell adhesion "hsa04015,hsa04510,hsa04611,hsa05131,hsa05166" Rap1 signaling pathway|Focal adhesion|Platelet activation|Shigellosis|Human T-cell leukemia virus 1 infection TLN2 219.0385336 161.2641518 276.8129153 1.716518595 0.779485486 0.026732137 0.872462931 0.534955954 0.902895975 83660 talin 2 "GO:0001726,GO:0003779,GO:0005178,GO:0005198,GO:0005200,GO:0005515,GO:0005737,GO:0005886,GO:0005925,GO:0007010,GO:0007043,GO:0007155,GO:0015629,GO:0045202,GO:0051015,GO:0098609" ruffle|actin binding|integrin binding|structural molecule activity|structural constituent of cytoskeleton|protein binding|cytoplasm|plasma membrane|focal adhesion|cytoskeleton organization|cell-cell junction assembly|cell adhesion|actin cytoskeleton|synapse|actin filament binding|cell-cell adhesion "hsa04015,hsa04510,hsa04611,hsa05131,hsa05166" Rap1 signaling pathway|Focal adhesion|Platelet activation|Shigellosis|Human T-cell leukemia virus 1 infection TLNRD1 378.3017299 380.791481 375.8119788 0.986923283 -0.018990151 0.958304219 1 4.176354599 4.05276983 59274 talin rod domain containing 1 "GO:0001725,GO:0003779,GO:0005515,GO:0042802" stress fiber|actin binding|protein binding|identical protein binding TLR1 27.66028665 32.25283036 23.06774294 0.715216081 -0.48354892 0.539168717 1 0.215806705 0.151765614 7096 toll like receptor 1 "GO:0001774,GO:0001775,GO:0002224,GO:0002755,GO:0004888,GO:0005515,GO:0005794,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0007165,GO:0016020,GO:0030670,GO:0032755,GO:0032757,GO:0032760,GO:0034130,GO:0034137,GO:0035354,GO:0035663,GO:0038023,GO:0038123,GO:0042116,GO:0042495,GO:0042802,GO:0045087,GO:0045121,GO:0050135,GO:0061809,GO:0071221,GO:0071723,GO:0071727" "microglial cell activation|cell activation|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|transmembrane signaling receptor activity|protein binding|Golgi apparatus|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|signal transduction|membrane|phagocytic vesicle membrane|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|toll-like receptor 1 signaling pathway|positive regulation of toll-like receptor 2 signaling pathway|Toll-like receptor 1-Toll-like receptor 2 protein complex|Toll-like receptor 2 binding|signaling receptor activity|toll-like receptor TLR1:TLR2 signaling pathway|macrophage activation|detection of triacyl bacterial lipopeptide|identical protein binding|innate immune response|membrane raft|NAD(P)+ nucleosidase activity|NAD+ nucleotidase, cyclic ADP-ribose generating|cellular response to bacterial lipopeptide|lipopeptide binding|cellular response to triacyl bacterial lipopeptide" "hsa04620,hsa05152" Toll-like receptor signaling pathway|Tuberculosis TLR2 106.8757807 131.0921492 82.65941222 0.630544336 -0.665330279 0.145496998 1 0.740881824 0.459341568 7097 toll like receptor 2 "GO:0001530,GO:0001540,GO:0001666,GO:0001774,GO:0001775,GO:0001875,GO:0002224,GO:0002755,GO:0004888,GO:0005515,GO:0005737,GO:0005794,GO:0005886,GO:0005887,GO:0006691,GO:0006915,GO:0006954,GO:0006955,GO:0007165,GO:0007252,GO:0007612,GO:0008285,GO:0009636,GO:0009986,GO:0010628,GO:0014005,GO:0030177,GO:0030667,GO:0030670,GO:0031226,GO:0031663,GO:0032289,GO:0032570,GO:0032613,GO:0032722,GO:0032728,GO:0032733,GO:0032735,GO:0032741,GO:0032755,GO:0032757,GO:0032760,GO:0032868,GO:0034123,GO:0034134,GO:0035325,GO:0035354,GO:0038023,GO:0038123,GO:0038124,GO:0038187,GO:0042495,GO:0042496,GO:0042497,GO:0042802,GO:0042834,GO:0042995,GO:0043312,GO:0044297,GO:0044877,GO:0045087,GO:0045121,GO:0045944,GO:0046209,GO:0048714,GO:0050135,GO:0050729,GO:0050765,GO:0050830,GO:0051092,GO:0051770,GO:0051964,GO:0061809,GO:0070542,GO:0071221,GO:0071223,GO:0071346,GO:0071726,GO:0071727,GO:1901224,GO:1903974,GO:1904466" "lipopolysaccharide binding|amyloid-beta binding|response to hypoxia|microglial cell activation|cell activation|lipopolysaccharide immune receptor activity|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|transmembrane signaling receptor activity|protein binding|cytoplasm|Golgi apparatus|plasma membrane|integral component of plasma membrane|leukotriene metabolic process|apoptotic process|inflammatory response|immune response|signal transduction|I-kappaB phosphorylation|learning|negative regulation of cell population proliferation|response to toxic substance|cell surface|positive regulation of gene expression|microglia development|positive regulation of Wnt signaling pathway|secretory granule membrane|phagocytic vesicle membrane|intrinsic component of plasma membrane|lipopolysaccharide-mediated signaling pathway|central nervous system myelin formation|response to progesterone|interleukin-10 production|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|response to insulin|positive regulation of toll-like receptor signaling pathway|toll-like receptor 2 signaling pathway|Toll-like receptor binding|Toll-like receptor 1-Toll-like receptor 2 protein complex|signaling receptor activity|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|pattern recognition receptor activity|detection of triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|triacyl lipopeptide binding|identical protein binding|peptidoglycan binding|cell projection|neutrophil degranulation|cell body|protein-containing complex binding|innate immune response|membrane raft|positive regulation of transcription by RNA polymerase II|nitric oxide metabolic process|positive regulation of oligodendrocyte differentiation|NAD(P)+ nucleosidase activity|positive regulation of inflammatory response|negative regulation of phagocytosis|defense response to Gram-positive bacterium|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|negative regulation of synapse assembly|NAD+ nucleotidase, cyclic ADP-ribose generating|response to fatty acid|cellular response to bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to interferon-gamma|cellular response to diacyl bacterial lipopeptide|cellular response to triacyl bacterial lipopeptide|positive regulation of NIK/NF-kappaB signaling|positive regulation of cellular response to macrophage colony-stimulating factor stimulus|positive regulation of matrix metallopeptidase secretion" "hsa04145,hsa04151,hsa04620,hsa05132,hsa05134,hsa05140,hsa05142,hsa05144,hsa05145,hsa05146,hsa05152,hsa05161,hsa05162,hsa05168,hsa05169,hsa05170,hsa05171,hsa05205,hsa05235,hsa05321,hsa05323" Phagosome|PI3K-Akt signaling pathway|Toll-like receptor signaling pathway|Salmonella infection|Legionellosis|Leishmaniasis|Chagas disease|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis B|Measles|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Proteoglycans in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease|Rheumatoid arthritis TLR3 64.09489422 55.14193578 73.04785266 1.324724126 0.405691949 0.46917858 1 0.489247509 0.637272602 7098 toll like receptor 3 "GO:0000139,GO:0001774,GO:0002224,GO:0002730,GO:0002756,GO:0003725,GO:0004888,GO:0005515,GO:0005615,GO:0005737,GO:0005765,GO:0005769,GO:0005789,GO:0005887,GO:0006954,GO:0006972,GO:0007165,GO:0007249,GO:0007250,GO:0007252,GO:0008584,GO:0009597,GO:0009986,GO:0010008,GO:0010628,GO:0016020,GO:0031012,GO:0032722,GO:0032727,GO:0032728,GO:0032729,GO:0032735,GO:0032755,GO:0032757,GO:0032760,GO:0034123,GO:0034128,GO:0034138,GO:0034346,GO:0035458,GO:0035666,GO:0035690,GO:0036020,GO:0038023,GO:0042742,GO:0042802,GO:0043065,GO:0043123,GO:0043330,GO:0043331,GO:0045087,GO:0045671,GO:0045766,GO:0045944,GO:0046330,GO:0050729,GO:0051092,GO:0051607,GO:0070266,GO:0071260,GO:0071346,GO:0071360,GO:0097190,GO:0097191,GO:0097527,GO:1901224" Golgi membrane|microglial cell activation|toll-like receptor signaling pathway|regulation of dendritic cell cytokine production|MyD88-independent toll-like receptor signaling pathway|double-stranded RNA binding|transmembrane signaling receptor activity|protein binding|extracellular space|cytoplasm|lysosomal membrane|early endosome|endoplasmic reticulum membrane|integral component of plasma membrane|inflammatory response|hyperosmotic response|signal transduction|I-kappaB kinase/NF-kappaB signaling|activation of NF-kappaB-inducing kinase activity|I-kappaB phosphorylation|male gonad development|detection of virus|cell surface|endosome membrane|positive regulation of gene expression|membrane|extracellular matrix|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|positive regulation of toll-like receptor signaling pathway|negative regulation of MyD88-independent toll-like receptor signaling pathway|toll-like receptor 3 signaling pathway|positive regulation of type III interferon production|cellular response to interferon-beta|TRIF-dependent toll-like receptor signaling pathway|cellular response to drug|endolysosome membrane|signaling receptor activity|defense response to bacterium|identical protein binding|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to exogenous dsRNA|response to dsRNA|innate immune response|negative regulation of osteoclast differentiation|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|positive regulation of inflammatory response|positive regulation of NF-kappaB transcription factor activity|defense response to virus|necroptotic process|cellular response to mechanical stimulus|cellular response to interferon-gamma|cellular response to exogenous dsRNA|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|necroptotic signaling pathway|positive regulation of NIK/NF-kappaB signaling "hsa04217,hsa04620,hsa05160,hsa05161,hsa05164,hsa05165,hsa05167,hsa05168,hsa05171" Necroptosis|Toll-like receptor signaling pathway|Hepatitis C|Hepatitis B|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Coronavirus disease - COVID-19 TLR4 173.7302255 195.5978099 151.862641 0.776402563 -0.365123213 0.343695997 1 0.815714279 0.62272486 7099 toll like receptor 4 "GO:0000187,GO:0001530,GO:0001540,GO:0001726,GO:0001875,GO:0001891,GO:0002218,GO:0002224,GO:0002322,GO:0002537,GO:0002730,GO:0002755,GO:0002756,GO:0004888,GO:0005102,GO:0005515,GO:0005737,GO:0005769,GO:0005794,GO:0005886,GO:0005887,GO:0006909,GO:0006954,GO:0006955,GO:0007249,GO:0007252,GO:0009897,GO:0009986,GO:0010008,GO:0010572,GO:0010628,GO:0010838,GO:0014002,GO:0016046,GO:0030890,GO:0031226,GO:0031663,GO:0032496,GO:0032497,GO:0032611,GO:0032689,GO:0032700,GO:0032707,GO:0032715,GO:0032720,GO:0032722,GO:0032727,GO:0032728,GO:0032729,GO:0032731,GO:0032732,GO:0032733,GO:0032735,GO:0032755,GO:0032757,GO:0032760,GO:0034128,GO:0034142,GO:0035666,GO:0038023,GO:0042088,GO:0042116,GO:0042742,GO:0042802,GO:0043032,GO:0043123,GO:0043235,GO:0045087,GO:0045348,GO:0045429,GO:0045671,GO:0045944,GO:0046330,GO:0046696,GO:0046982,GO:0048471,GO:0050135,GO:0050729,GO:0050829,GO:0051092,GO:0051770,GO:0060729,GO:0060907,GO:0061809,GO:0070266,GO:0070373,GO:0070374,GO:0070430,GO:0070434,GO:0071222,GO:0071223,GO:0071260,GO:0071346,GO:0097190,GO:0120163,GO:0140052,GO:1900017,GO:1900227,GO:1901224,GO:1903223,GO:1903428,GO:1903974,GO:1904466,GO:1904646,GO:2000343" "activation of MAPK activity|lipopolysaccharide binding|amyloid-beta binding|ruffle|lipopolysaccharide immune receptor activity|phagocytic cup|activation of innate immune response|toll-like receptor signaling pathway|B cell proliferation involved in immune response|nitric oxide production involved in inflammatory response|regulation of dendritic cell cytokine production|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|transmembrane signaling receptor activity|signaling receptor binding|protein binding|cytoplasm|early endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|phagocytosis|inflammatory response|immune response|I-kappaB kinase/NF-kappaB signaling|I-kappaB phosphorylation|external side of plasma membrane|cell surface|endosome membrane|positive regulation of platelet activation|positive regulation of gene expression|positive regulation of keratinocyte proliferation|astrocyte development|detection of fungus|positive regulation of B cell proliferation|intrinsic component of plasma membrane|lipopolysaccharide-mediated signaling pathway|response to lipopolysaccharide|detection of lipopolysaccharide|interleukin-1 beta production|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|negative regulation of MyD88-independent toll-like receptor signaling pathway|toll-like receptor 4 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|signaling receptor activity|T-helper 1 type immune response|macrophage activation|defense response to bacterium|identical protein binding|positive regulation of macrophage activation|positive regulation of I-kappaB kinase/NF-kappaB signaling|receptor complex|innate immune response|positive regulation of MHC class II biosynthetic process|positive regulation of nitric oxide biosynthetic process|negative regulation of osteoclast differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|lipopolysaccharide receptor complex|protein heterodimerization activity|perinuclear region of cytoplasm|NAD(P)+ nucleosidase activity|positive regulation of inflammatory response|defense response to Gram-negative bacterium|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|intestinal epithelial structure maintenance|positive regulation of macrophage cytokine production|NAD+ nucleotidase, cyclic ADP-ribose generating|necroptotic process|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway|positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|cellular response to mechanical stimulus|cellular response to interferon-gamma|apoptotic signaling pathway|negative regulation of cold-induced thermogenesis|cellular response to oxidised low-density lipoprotein particle stimulus|positive regulation of cytokine production involved in inflammatory response|positive regulation of NLRP3 inflammasome complex assembly|positive regulation of NIK/NF-kappaB signaling|positive regulation of oxidative stress-induced neuron death|positive regulation of reactive oxygen species biosynthetic process|positive regulation of cellular response to macrophage colony-stimulating factor stimulus|positive regulation of matrix metallopeptidase secretion|cellular response to amyloid-beta|positive regulation of chemokine (C-X-C motif) ligand 2 production" "hsa04064,hsa04066,hsa04145,hsa04151,hsa04217,hsa04620,hsa04621,hsa05130,hsa05131,hsa05132,hsa05133,hsa05134,hsa05135,hsa05140,hsa05142,hsa05144,hsa05145,hsa05146,hsa05152,hsa05161,hsa05162,hsa05164,hsa05170,hsa05171,hsa05205,hsa05235,hsa05321,hsa05323" NF-kappa B signaling pathway|HIF-1 signaling pathway|Phagosome|PI3K-Akt signaling pathway|Necroptosis|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Leishmaniasis|Chagas disease|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis B|Measles|Influenza A|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Proteoglycans in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease|Rheumatoid arthritis TLR6 396.8555727 451.5396251 342.1715203 0.757788467 -0.400132911 0.167318943 1 3.103791846 2.312659835 10333 toll like receptor 6 "GO:0001540,GO:0001774,GO:0001775,GO:0002224,GO:0002755,GO:0004888,GO:0005102,GO:0005515,GO:0005794,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0007165,GO:0007250,GO:0010628,GO:0030670,GO:0032611,GO:0032717,GO:0032755,GO:0034136,GO:0034150,GO:0035355,GO:0035663,GO:0035666,GO:0038023,GO:0038124,GO:0042496,GO:0042742,GO:0042802,GO:0043032,GO:0043123,GO:0043235,GO:0043507,GO:0045087,GO:0045121,GO:0045429,GO:0046209,GO:0046982,GO:0050135,GO:0051092,GO:0061809,GO:0071221,GO:0071723,GO:0071726,GO:0140052,GO:1900017,GO:1900227,GO:1903223,GO:1903428,GO:1904646" "amyloid-beta binding|microglial cell activation|cell activation|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|transmembrane signaling receptor activity|signaling receptor binding|protein binding|Golgi apparatus|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|signal transduction|activation of NF-kappaB-inducing kinase activity|positive regulation of gene expression|phagocytic vesicle membrane|interleukin-1 beta production|negative regulation of interleukin-8 production|positive regulation of interleukin-6 production|negative regulation of toll-like receptor 2 signaling pathway|toll-like receptor 6 signaling pathway|Toll-like receptor 2-Toll-like receptor 6 protein complex|Toll-like receptor 2 binding|TRIF-dependent toll-like receptor signaling pathway|signaling receptor activity|toll-like receptor TLR6:TLR2 signaling pathway|detection of diacyl bacterial lipopeptide|defense response to bacterium|identical protein binding|positive regulation of macrophage activation|positive regulation of I-kappaB kinase/NF-kappaB signaling|receptor complex|positive regulation of JUN kinase activity|innate immune response|membrane raft|positive regulation of nitric oxide biosynthetic process|nitric oxide metabolic process|protein heterodimerization activity|NAD(P)+ nucleosidase activity|positive regulation of NF-kappaB transcription factor activity|NAD+ nucleotidase, cyclic ADP-ribose generating|cellular response to bacterial lipopeptide|lipopeptide binding|cellular response to diacyl bacterial lipopeptide|cellular response to oxidised low-density lipoprotein particle stimulus|positive regulation of cytokine production involved in inflammatory response|positive regulation of NLRP3 inflammasome complex assembly|positive regulation of oxidative stress-induced neuron death|positive regulation of reactive oxygen species biosynthetic process|cellular response to amyloid-beta" "hsa04145,hsa04620,hsa05132,hsa05142,hsa05152" Phagosome|Toll-like receptor signaling pathway|Salmonella infection|Chagas disease|Tuberculosis TLR9 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.049694192 0 54106 toll like receptor 9 "GO:0000139,GO:0002224,GO:0002237,GO:0002639,GO:0002755,GO:0004888,GO:0005149,GO:0005576,GO:0005737,GO:0005764,GO:0005768,GO:0005783,GO:0005789,GO:0005886,GO:0006954,GO:0006955,GO:0007249,GO:0007252,GO:0010008,GO:0010628,GO:0016021,GO:0016323,GO:0016324,GO:0030277,GO:0030890,GO:0032009,GO:0032088,GO:0032640,GO:0032715,GO:0032717,GO:0032722,GO:0032725,GO:0032727,GO:0032728,GO:0032729,GO:0032733,GO:0032735,GO:0032741,GO:0032755,GO:0032757,GO:0032760,GO:0034122,GO:0034123,GO:0034162,GO:0034163,GO:0035197,GO:0036019,GO:0036020,GO:0038187,GO:0042742,GO:0042803,GO:0043123,GO:0043410,GO:0043507,GO:0045087,GO:0045322,GO:0045577,GO:0045944,GO:0046330,GO:0050729,GO:0050829,GO:0050871,GO:0051092,GO:0051607,GO:0051770,GO:1901224,GO:1901895" Golgi membrane|toll-like receptor signaling pathway|response to molecule of bacterial origin|positive regulation of immunoglobulin production|MyD88-dependent toll-like receptor signaling pathway|transmembrane signaling receptor activity|interleukin-1 receptor binding|extracellular region|cytoplasm|lysosome|endosome|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|inflammatory response|immune response|I-kappaB kinase/NF-kappaB signaling|I-kappaB phosphorylation|endosome membrane|positive regulation of gene expression|integral component of membrane|basolateral plasma membrane|apical plasma membrane|maintenance of gastrointestinal epithelium|positive regulation of B cell proliferation|early phagosome|negative regulation of NF-kappaB transcription factor activity|tumor necrosis factor production|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|positive regulation of chemokine production|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|negative regulation of toll-like receptor signaling pathway|positive regulation of toll-like receptor signaling pathway|toll-like receptor 9 signaling pathway|regulation of toll-like receptor 9 signaling pathway|siRNA binding|endolysosome|endolysosome membrane|pattern recognition receptor activity|defense response to bacterium|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAPK cascade|positive regulation of JUN kinase activity|innate immune response|unmethylated CpG binding|regulation of B cell differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|positive regulation of inflammatory response|defense response to Gram-negative bacterium|positive regulation of B cell activation|positive regulation of NF-kappaB transcription factor activity|defense response to virus|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of NIK/NF-kappaB signaling|negative regulation of ATPase-coupled calcium transmembrane transporter activity "hsa04620,hsa05132,hsa05142,hsa05143,hsa05144,hsa05152,hsa05162,hsa05168,hsa05235" Toll-like receptor signaling pathway|Salmonella infection|Chagas disease|African trypanosomiasis|Malaria|Tuberculosis|Measles|Herpes simplex virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer TM2D1 646.9681286 621.1270879 672.8091692 1.083206935 0.115308881 0.660551324 1 34.20888658 36.43523287 83941 TM2 domain containing 1 "GO:0001540,GO:0004930,GO:0005515,GO:0007186,GO:0016021,GO:0097190" amyloid-beta binding|G protein-coupled receptor activity|protein binding|G protein-coupled receptor signaling pathway|integral component of membrane|apoptotic signaling pathway TM2D2 573.4006834 519.1665274 627.6348393 1.208927783 0.273728066 0.303098392 1 7.446106794 8.85117236 83877 TM2 domain containing 2 "GO:0005515,GO:0016021" protein binding|integral component of membrane TM2D3 383.4295718 376.6298255 390.2293181 1.036108379 0.05117492 0.86985709 1 9.361919689 9.537647685 80213 TM2 domain containing 3 "GO:0044214,GO:0045747,GO:0046331" spanning component of plasma membrane|positive regulation of Notch signaling pathway|lateral inhibition TM4SF1 6150.922649 4857.692418 7444.152879 1.532446322 0.615836541 0.011334938 0.63010276 151.8723587 228.8417117 4071 transmembrane 4 L six family member 1 "GO:0003674,GO:0005515,GO:0005887,GO:0008150,GO:0016021" molecular_function|protein binding|integral component of plasma membrane|biological_process|integral component of membrane TM4SF19 1012.333268 1103.879129 920.7874058 0.834137888 -0.261642205 0.286913773 1 57.4191036 47.09398433 116211 transmembrane 4 L six family member 19 "GO:0005515,GO:0016021" protein binding|integral component of membrane TM6SF1 10.60731406 13.52538047 7.689247648 0.56850509 -0.814754828 0.49718369 1 0.112961611 0.063144629 53346 transmembrane 6 superfamily member 1 "GO:0003674,GO:0005765,GO:0008150,GO:0016021" molecular_function|lysosomal membrane|biological_process|integral component of membrane TM7SF2 203.2385965 213.2848459 193.1923472 0.905795001 -0.142743518 0.702346821 1 7.213320803 6.424455795 7108 transmembrane 7 superfamily member 2 "GO:0005515,GO:0005637,GO:0005783,GO:0005789,GO:0005887,GO:0006695,GO:0016126,GO:0016627,GO:0030176,GO:0043231,GO:0043235,GO:0045540,GO:0050613,GO:0050661,GO:0055114" "protein binding|nuclear inner membrane|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of plasma membrane|cholesterol biosynthetic process|sterol biosynthetic process|oxidoreductase activity, acting on the CH-CH group of donors|integral component of endoplasmic reticulum membrane|intracellular membrane-bounded organelle|receptor complex|regulation of cholesterol biosynthetic process|delta14-sterol reductase activity|NADP binding|oxidation-reduction process" hsa00100 Steroid biosynthesis TM7SF3 1821.329788 1840.492158 1802.167417 0.979176906 -0.030358562 0.900374806 1 10.35896265 9.973523326 51768 transmembrane 7 superfamily member 3 "GO:0003674,GO:0005886,GO:0016021,GO:0032024,GO:0034620,GO:0043069,GO:0070062" molecular_function|plasma membrane|integral component of membrane|positive regulation of insulin secretion|cellular response to unfolded protein|negative regulation of programmed cell death|extracellular exosome TM9SF1 1247.552937 1260.981626 1234.124247 0.978701214 -0.031059606 0.900941943 1 26.47374972 25.47632404 10548 transmembrane 9 superfamily member 1 "GO:0000421,GO:0005765,GO:0006914,GO:0016020,GO:0016021,GO:0031410,GO:0072657" autophagosome membrane|lysosomal membrane|autophagy|membrane|integral component of membrane|cytoplasmic vesicle|protein localization to membrane TM9SF2 4529.619783 4243.848227 4815.39134 1.134675672 0.182279986 0.446016921 1 66.28223003 73.95031593 9375 transmembrane 9 superfamily member 2 "GO:0005768,GO:0005856,GO:0005887,GO:0010008,GO:0016020,GO:0070062,GO:0072657,GO:0150051" endosome|cytoskeleton|integral component of plasma membrane|endosome membrane|membrane|extracellular exosome|protein localization to membrane|postsynaptic Golgi apparatus TM9SF3 11572.018 10981.56853 12162.46747 1.107534632 0.147351812 0.563264601 1 90.17789341 98.20386482 56889 transmembrane 9 superfamily member 3 "GO:0016020,GO:0016021,GO:0072657" membrane|integral component of membrane|protein localization to membrane TM9SF4 3087.380618 3410.476707 2764.284529 0.810527315 -0.303067289 0.200681427 1 45.74286848 36.45543034 9777 transmembrane 9 superfamily member 4 "GO:0001666,GO:0005515,GO:0005769,GO:0005794,GO:0006909,GO:0007155,GO:0016020,GO:0016021,GO:0051453,GO:0070072,GO:0070863,GO:0072657,GO:2000010" response to hypoxia|protein binding|early endosome|Golgi apparatus|phagocytosis|cell adhesion|membrane|integral component of membrane|regulation of intracellular pH|vacuolar proton-transporting V-type ATPase complex assembly|positive regulation of protein exit from endoplasmic reticulum|protein localization to membrane|positive regulation of protein localization to cell surface TMA16 439.9440444 459.8629361 420.0251528 0.913370311 -0.1307282 0.647919865 1 14.032041 12.60198372 55319 translation machinery associated 16 homolog "GO:0005515,GO:0005634,GO:0005654,GO:0005730" protein binding|nucleus|nucleoplasm|nucleolus TMA7 1390.404097 1163.182721 1617.625474 1.390689051 0.475799879 0.047203914 1 110.6540534 151.3103171 51372 translation machinery associated 7 homolog GO:0002181 cytoplasmic translation TMBIM1 3371.463183 3159.736962 3583.189404 1.134015093 0.181439842 0.444498884 1 53.84079 60.03457451 64114 transmembrane BAX inhibitor motif containing 1 "GO:0005123,GO:0005515,GO:0005765,GO:0005794,GO:0005886,GO:0010008,GO:0016021,GO:0035579,GO:0043086,GO:0043231,GO:0043312,GO:0070062,GO:1902042,GO:1902045,GO:1903077,GO:2000504" death receptor binding|protein binding|lysosomal membrane|Golgi apparatus|plasma membrane|endosome membrane|integral component of membrane|specific granule membrane|negative regulation of catalytic activity|intracellular membrane-bounded organelle|neutrophil degranulation|extracellular exosome|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of Fas signaling pathway|negative regulation of protein localization to plasma membrane|positive regulation of blood vessel remodeling TMBIM4 851.1232217 845.8564866 856.3899568 1.012453023 0.01785497 0.948116749 1 14.9624813 14.89531461 51643 transmembrane BAX inhibitor motif containing 4 "GO:0000139,GO:0005515,GO:0005795,GO:0006915,GO:0016021,GO:0043066,GO:0050848" Golgi membrane|protein binding|Golgi stack|apoptotic process|integral component of membrane|negative regulation of apoptotic process|regulation of calcium-mediated signaling TMBIM6 17131.31394 15926.65572 18335.97217 1.151275729 0.203233399 0.446915304 1 231.0974289 261.6047597 7009 transmembrane BAX inhibitor motif containing 6 "GO:0002638,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0005887,GO:0006914,GO:0010523,GO:0016020,GO:0016021,GO:0019899,GO:0031625,GO:0031966,GO:0032091,GO:0032469,GO:0033119,GO:0034620,GO:0043066,GO:0060698,GO:0060702,GO:0070059,GO:1902065,GO:1902236,GO:1903298,GO:1990441,GO:2001234" negative regulation of immunoglobulin production|protein binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of plasma membrane|autophagy|negative regulation of calcium ion transport into cytosol|membrane|integral component of membrane|enzyme binding|ubiquitin protein ligase binding|mitochondrial membrane|negative regulation of protein binding|endoplasmic reticulum calcium ion homeostasis|negative regulation of RNA splicing|cellular response to unfolded protein|negative regulation of apoptotic process|endoribonuclease inhibitor activity|negative regulation of endoribonuclease activity|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|response to L-glutamate|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway|negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|negative regulation of apoptotic signaling pathway hsa05130 Pathogenic Escherichia coli infection TMC4 21.89838134 19.76786377 24.0288989 1.215553647 0.281613566 0.777119974 1 0.44085857 0.526919895 147798 transmembrane channel like 4 "GO:0005887,GO:0008381,GO:0034220,GO:0070062" integral component of plasma membrane|mechanosensitive ion channel activity|ion transmembrane transport|extracellular exosome TMC6 282.7321077 218.4869154 346.9773001 1.588091898 0.667294399 0.038242018 0.982059825 1.320974862 2.062725141 11322 transmembrane channel like 6 "GO:0005515,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005887,GO:0008150,GO:0008381,GO:0031965,GO:0034220,GO:0035579,GO:0043312,GO:0070062,GO:0070821" protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|biological_process|mechanosensitive ion channel activity|nuclear membrane|ion transmembrane transport|specific granule membrane|neutrophil degranulation|extracellular exosome|tertiary granule membrane TMC7 156.3205922 167.5066351 145.1345494 0.8664406 -0.206827249 0.613536373 1 1.903645922 1.621795704 79905 transmembrane channel like 7 "GO:0005887,GO:0008381,GO:0034220" integral component of plasma membrane|mechanosensitive ion channel activity|ion transmembrane transport TMC8 6.485287494 6.242483296 6.728091692 1.0777909 0.108077311 1 1 0.053977618 0.057203079 147138 transmembrane channel like 8 "GO:0001558,GO:0005515,GO:0005615,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005887,GO:0008381,GO:0031333,GO:0031965,GO:0032091,GO:0034220,GO:0043120,GO:0055069,GO:0070062,GO:0140311,GO:1902041" regulation of cell growth|protein binding|extracellular space|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|integral component of plasma membrane|mechanosensitive ion channel activity|negative regulation of protein-containing complex assembly|nuclear membrane|negative regulation of protein binding|ion transmembrane transport|tumor necrosis factor binding|zinc ion homeostasis|extracellular exosome|protein sequestering activity|regulation of extrinsic apoptotic signaling pathway via death domain receptors TMCC1 452.1962677 466.1054194 438.2871159 0.940317571 -0.088780018 0.757482191 1 3.107456536 2.873100337 23023 transmembrane and coiled-coil domain family 1 "GO:0005515,GO:0005789,GO:0005791,GO:0005829,GO:0007029,GO:0012505,GO:0016021,GO:0016197,GO:0042802,GO:0090148,GO:0097750,GO:0140284,GO:0140285" protein binding|endoplasmic reticulum membrane|rough endoplasmic reticulum|cytosol|endoplasmic reticulum organization|endomembrane system|integral component of membrane|endosomal transport|identical protein binding|membrane fission|endosome membrane tubulation|endoplasmic reticulum-endosome membrane contact site|endosome fission TMCC2 301.7319299 275.7096789 327.754181 1.188765597 0.24946427 0.430282964 1 2.720805997 3.180277251 9911 transmembrane and coiled-coil domain family 2 "GO:0005515,GO:0005783,GO:0005789,GO:0012505,GO:0016021,GO:0042982" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endomembrane system|integral component of membrane|amyloid precursor protein metabolic process TMCC3 629.2911534 560.7830827 697.7992241 1.244330019 0.315369165 0.226746207 1 5.027374845 6.151032544 57458 transmembrane and coiled-coil domain family 3 "GO:0005515,GO:0005783,GO:0005789,GO:0012505,GO:0016021,GO:0042802,GO:0071889" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endomembrane system|integral component of membrane|identical protein binding|14-3-3 protein binding TMCO1 1336.692606 1279.709076 1393.676136 1.089057007 0.123079475 0.610007639 1 14.62435147 15.66023981 54499 transmembrane and coiled-coil domains 1 "GO:0000139,GO:0005262,GO:0005737,GO:0005783,GO:0006874,GO:0006983,GO:0030176,GO:0032469,GO:0070588" Golgi membrane|calcium channel activity|cytoplasm|endoplasmic reticulum|cellular calcium ion homeostasis|ER overload response|integral component of endoplasmic reticulum membrane|endoplasmic reticulum calcium ion homeostasis|calcium ion transmembrane transport TMCO3 1744.43351 1651.136832 1837.730188 1.113009021 0.154465285 0.515923135 1 7.50324745 8.211436372 55002 transmembrane and coiled-coil domains 3 "GO:0015299,GO:0016021,GO:1902600" solute:proton antiporter activity|integral component of membrane|proton transmembrane transport TMCO4 206.4390961 221.608157 191.2700352 0.863100158 -0.21240011 0.560677205 1 1.983367439 1.683199346 255104 transmembrane and coiled-coil domains 4 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMCO6 269.0972868 264.2651262 273.9294475 1.036570551 0.051818312 0.885389655 1 4.740619861 4.831758025 55374 transmembrane and coiled-coil domains 6 "GO:0005515,GO:0006606,GO:0016021,GO:0061608" protein binding|protein import into nucleus|integral component of membrane|nuclear import signal receptor activity TMED1 193.7855528 217.4465015 170.1246042 0.782374529 -0.354068692 0.338011006 1 6.586106773 5.066577019 11018 transmembrane p24 trafficking protein 1 "GO:0005102,GO:0005515,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0005886,GO:0006886,GO:0006888,GO:0007030,GO:0007165,GO:0007267,GO:0016021,GO:0030134,GO:0033116" signaling receptor binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|plasma membrane|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|signal transduction|cell-cell signaling|integral component of membrane|COPII-coated ER to Golgi transport vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane TMED10 6634.195627 6518.192975 6750.198279 1.0355935 0.050457816 0.836382498 1 84.65903605 86.20526948 10972 transmembrane p24 trafficking protein 10 "GO:0000139,GO:0001822,GO:0005515,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0005801,GO:0005886,GO:0006886,GO:0006888,GO:0006890,GO:0007030,GO:0008320,GO:0012507,GO:0016021,GO:0019905,GO:0030133,GO:0030134,GO:0030137,GO:0030140,GO:0030667,GO:0032612,GO:0033116,GO:0035459,GO:0035964,GO:0042470,GO:0042589,GO:0043279,GO:0044877,GO:0045055,GO:0048199,GO:0048205,GO:0048208,GO:0050714,GO:0070765,GO:0071806,GO:0106272,GO:0106273,GO:1902003,GO:1902960" "Golgi membrane|kidney development|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|plasma membrane|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|protein transmembrane transporter activity|ER to Golgi transport vesicle membrane|integral component of membrane|syntaxin binding|transport vesicle|COPII-coated ER to Golgi transport vesicle|COPI-coated vesicle|trans-Golgi network transport vesicle|secretory granule membrane|interleukin-1 production|endoplasmic reticulum-Golgi intermediate compartment membrane|vesicle cargo loading|COPI-coated vesicle budding|melanosome|zymogen granule membrane|response to alkaloid|protein-containing complex binding|regulated exocytosis|vesicle targeting, to, from or within Golgi|COPI coating of Golgi vesicle|COPII vesicle coating|positive regulation of protein secretion|gamma-secretase complex|protein transmembrane transport|protein localization to ERGIC|cytosol to ERGIC protein transport|regulation of amyloid-beta formation|negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" hsa05130 Pathogenic Escherichia coli infection TMED2 5224.139365 5028.320295 5419.958436 1.077886475 0.108205238 0.653130478 1 104.6207456 110.8822454 10959 transmembrane p24 trafficking protein 2 "GO:0000139,GO:0001843,GO:0001893,GO:0001947,GO:0005515,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0006886,GO:0006888,GO:0006890,GO:0007030,GO:0010628,GO:0012507,GO:0016021,GO:0030133,GO:0030134,GO:0030137,GO:0030663,GO:0032525,GO:0032580,GO:0033116,GO:0034260,GO:0035264,GO:0035459,GO:0036342,GO:0036499,GO:0042589,GO:0043231,GO:0048205,GO:0048208,GO:0060716,GO:0072659,GO:0090158,GO:1903912,GO:2000638" "Golgi membrane|neural tube closure|maternal placenta development|heart looping|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|positive regulation of gene expression|ER to Golgi transport vesicle membrane|integral component of membrane|transport vesicle|COPII-coated ER to Golgi transport vesicle|COPI-coated vesicle|COPI-coated vesicle membrane|somite rostral/caudal axis specification|Golgi cisterna membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|negative regulation of GTPase activity|multicellular organism growth|vesicle cargo loading|post-anal tail morphogenesis|PERK-mediated unfolded protein response|zymogen granule membrane|intracellular membrane-bounded organelle|COPI coating of Golgi vesicle|COPII vesicle coating|labyrinthine layer blood vessel development|protein localization to plasma membrane|endoplasmic reticulum membrane organization|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation|regulation of SREBP signaling pathway" TMED3 1475.979733 1479.468541 1472.490925 0.995283701 -0.006820278 0.980400362 1 12.31002758 12.04694968 23423 transmembrane p24 trafficking protein 3 "GO:0000139,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0006886,GO:0006888,GO:0006890,GO:0007030,GO:0016021,GO:0030126,GO:0030133,GO:0030134,GO:0032580,GO:0033116" "Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|integral component of membrane|COPI vesicle coat|transport vesicle|COPII-coated ER to Golgi transport vesicle|Golgi cisterna membrane|endoplasmic reticulum-Golgi intermediate compartment membrane" TMED4 2479.754373 2156.777979 2802.730768 1.299498973 0.377955493 0.109967081 1 31.00007453 39.61045737 222068 transmembrane p24 trafficking protein 4 "GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0006886,GO:0006888,GO:0007030,GO:0016021,GO:0030134,GO:0043123" endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|integral component of membrane|COPII-coated ER to Golgi transport vesicle|positive regulation of I-kappaB kinase/NF-kappaB signaling TMED5 2564.210337 2468.902144 2659.51853 1.077206943 0.107295434 0.650810707 1 22.56950492 23.90519855 50999 transmembrane p24 trafficking protein 5 "GO:0005515,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0005801,GO:0006886,GO:0006888,GO:0007030,GO:0016021,GO:0030134,GO:0033116,GO:0070971,GO:0090161" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|integral component of membrane|COPII-coated ER to Golgi transport vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|endoplasmic reticulum exit site|Golgi ribbon formation TMED7 2738.848227 2499.074146 2978.622308 1.19189033 0.253251494 0.284370898 1 34.04058042 39.89371045 51014 transmembrane p24 trafficking protein 7 "GO:0000139,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0006886,GO:0006888,GO:0006890,GO:0007030,GO:0016021,GO:0030126,GO:0030127,GO:0030133,GO:0030134,GO:0033116" "Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|integral component of membrane|COPI vesicle coat|COPII vesicle coat|transport vesicle|COPII-coated ER to Golgi transport vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane" TMED8 1623.917263 1679.228007 1568.60652 0.934123606 -0.098314631 0.680926389 1 11.21618428 10.30197904 283578 transmembrane p24 trafficking protein family member 8 GO:0005515 protein binding TMED9 2726.833163 2599.994293 2853.672033 1.097568576 0.134311082 0.570699919 1 54.49996733 58.81648749 54732 transmembrane p24 trafficking protein 9 "GO:0000139,GO:0005515,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0007030,GO:0008021,GO:0010638,GO:0016021,GO:0019905,GO:0030133,GO:0030134,GO:0030140,GO:0032527,GO:0033116,GO:0034498,GO:0048205,GO:0070062" "Golgi membrane|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|synaptic vesicle|positive regulation of organelle organization|integral component of membrane|syntaxin binding|transport vesicle|COPII-coated ER to Golgi transport vesicle|trans-Golgi network transport vesicle|protein exit from endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment membrane|early endosome to Golgi transport|COPI coating of Golgi vesicle|extracellular exosome" TMEFF1 15.89367182 13.52538047 18.26196316 1.350199589 0.433172685 0.689082402 1 0.280320271 0.372154825 8577 transmembrane protein with EGF like and two follistatin like domains 1 "GO:0005102,GO:0005604,GO:0005886,GO:0008045,GO:0009887,GO:0009888,GO:0016021,GO:0016358" signaling receptor binding|basement membrane|plasma membrane|motor neuron axon guidance|animal organ morphogenesis|tissue development|integral component of membrane|dendrite development TMEFF2 205.5823502 161.2641518 249.9005486 1.549634843 0.631928298 0.079094383 1 1.013348804 1.544043426 23671 transmembrane protein with EGF like and two follistatin like domains 2 "GO:0003674,GO:0005515,GO:0005604,GO:0005886,GO:0009887,GO:0009888,GO:0016021,GO:0016477,GO:0030336,GO:0034446,GO:0044319,GO:0045720,GO:0051497" "molecular_function|protein binding|basement membrane|plasma membrane|animal organ morphogenesis|tissue development|integral component of membrane|cell migration|negative regulation of cell migration|substrate adhesion-dependent cell spreading|wound healing, spreading of cells|negative regulation of integrin biosynthetic process|negative regulation of stress fiber assembly" TMEM101 690.1754872 632.5716406 747.7793338 1.182125922 0.241383722 0.348198271 1 15.99961414 18.59706583 84336 transmembrane protein 101 "GO:0005515,GO:0005575,GO:0016021,GO:0043123" protein binding|cellular_component|integral component of membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling TMEM102 254.8485242 243.4568485 266.2401998 1.093582708 0.129062337 0.706745827 1 6.079945976 6.537663053 284114 transmembrane protein 102 "GO:0005515,GO:0005739,GO:0005886,GO:0006915,GO:0007165,GO:0009986,GO:0010820,GO:0016021,GO:0032991,GO:0034097,GO:0042981,GO:0045785,GO:0050730,GO:1901028,GO:2000406" protein binding|mitochondrion|plasma membrane|apoptotic process|signal transduction|cell surface|positive regulation of T cell chemotaxis|integral component of membrane|protein-containing complex|response to cytokine|regulation of apoptotic process|positive regulation of cell adhesion|regulation of peptidyl-tyrosine phosphorylation|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of T cell migration TMEM104 472.0188517 469.2266611 474.8110423 1.011901244 0.017068498 0.959303747 1 3.076383845 3.060904858 54868 transmembrane protein 104 "GO:0003674,GO:0005575,GO:0008150,GO:0016021" molecular_function|cellular_component|biological_process|integral component of membrane TMEM106A 149.9642525 139.4154603 160.5130447 1.151328872 0.203299992 0.626099783 1 2.262879221 2.561721711 113277 transmembrane protein 106A "GO:0003674,GO:0005515,GO:0005886,GO:0008150,GO:0016021,GO:0032611,GO:0032635,GO:0032640,GO:0035780,GO:0035781,GO:0042116,GO:0043123,GO:0043410,GO:0045087,GO:0045348,GO:1904407" molecular_function|protein binding|plasma membrane|biological_process|integral component of membrane|interleukin-1 beta production|interleukin-6 production|tumor necrosis factor production|CD80 biosynthetic process|CD86 biosynthetic process|macrophage activation|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAPK cascade|innate immune response|positive regulation of MHC class II biosynthetic process|positive regulation of nitric oxide metabolic process TMEM106B 2027.93243 2053.777004 2002.087856 0.974832152 -0.03677426 0.878445733 1 16.69809629 16.00545351 54664 transmembrane protein 106B "GO:0003674,GO:0005515,GO:0005764,GO:0005765,GO:0005768,GO:0007040,GO:0007041,GO:0016021,GO:0031902,GO:0032418,GO:0048813" molecular_function|protein binding|lysosome|lysosomal membrane|endosome|lysosome organization|lysosomal transport|integral component of membrane|late endosome membrane|lysosome localization|dendrite morphogenesis TMEM106C 3461.362062 2983.907015 3938.817108 1.320020057 0.40055985 0.091607272 1 97.75668092 126.8814568 79022 transmembrane protein 106C "GO:0003674,GO:0005515,GO:0005575,GO:0005789,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|endoplasmic reticulum membrane|biological_process|integral component of membrane TMEM107 468.0358337 415.1251392 520.9465281 1.254914432 0.327588995 0.238651591 1 9.712611008 11.98453776 84314 transmembrane protein 107 "GO:0003127,GO:0003674,GO:0005515,GO:0010468,GO:0016021,GO:0021532,GO:0035869,GO:0036038,GO:0042733,GO:0060021,GO:0060271,GO:0097094,GO:1904491,GO:1905515" detection of nodal flow|molecular_function|protein binding|regulation of gene expression|integral component of membrane|neural tube patterning|ciliary transition zone|MKS complex|embryonic digit morphogenesis|roof of mouth development|cilium assembly|craniofacial suture morphogenesis|protein localization to ciliary transition zone|non-motile cilium assembly TMEM109 1889.234707 1882.108714 1896.360701 1.007572351 0.010883438 0.965812131 1 47.17927801 46.7410765 79073 transmembrane protein 109 "GO:0003674,GO:0005244,GO:0005515,GO:0005640,GO:0016021,GO:0033017,GO:0034220,GO:0034765,GO:0042771,GO:0060548,GO:0070062,GO:0071480" molecular_function|voltage-gated ion channel activity|protein binding|nuclear outer membrane|integral component of membrane|sarcoplasmic reticulum membrane|ion transmembrane transport|regulation of ion transmembrane transport|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of cell death|extracellular exosome|cellular response to gamma radiation TMEM11 474.5009995 471.3074888 477.6945101 1.013551708 0.019419692 0.952370844 1 26.25554745 26.16604996 8834 transmembrane protein 11 "GO:0003674,GO:0005515,GO:0005739,GO:0005887,GO:0007005,GO:0007007,GO:0031305" molecular_function|protein binding|mitochondrion|integral component of plasma membrane|mitochondrion organization|inner mitochondrial membrane organization|integral component of mitochondrial inner membrane TMEM115 796.4518031 760.5425482 832.3610579 1.094430627 0.130180509 0.607858843 1 19.26376743 20.73006401 11070 transmembrane protein 115 "GO:0000139,GO:0003674,GO:0005515,GO:0005634,GO:0005794,GO:0006888,GO:0006890,GO:0008285,GO:0015031,GO:0016021,GO:0017119,GO:0032580,GO:0042802" "Golgi membrane|molecular_function|protein binding|nucleus|Golgi apparatus|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|negative regulation of cell population proliferation|protein transport|integral component of membrane|Golgi transport complex|Golgi cisterna membrane|identical protein binding" TMEM116 143.5978519 136.2942186 150.9014851 1.107174513 0.146882637 0.734553765 1 2.118163061 2.305932807 89894 transmembrane protein 116 "GO:0003674,GO:0005575,GO:0008150,GO:0016021" molecular_function|cellular_component|biological_process|integral component of membrane TMEM117 106.1278608 98.83931885 113.4164028 1.147482643 0.198472331 0.67887687 1 1.528505589 1.724583929 84216 transmembrane protein 117 "GO:0003674,GO:0005783,GO:0005886,GO:0016021,GO:0070059" molecular_function|endoplasmic reticulum|plasma membrane|integral component of membrane|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress TMEM120A 487.7936366 479.6307999 495.9564733 1.034038 0.048289205 0.86780075 1 15.3000683 15.5561115 83862 transmembrane protein 120A "GO:0003674,GO:0005216,GO:0005515,GO:0005575,GO:0005637,GO:0005886,GO:0016020,GO:0016021,GO:0034220,GO:0045444,GO:0050966,GO:0051260,GO:0051291" molecular_function|ion channel activity|protein binding|cellular_component|nuclear inner membrane|plasma membrane|membrane|integral component of membrane|ion transmembrane transport|fat cell differentiation|detection of mechanical stimulus involved in sensory perception of pain|protein homooligomerization|protein heterooligomerization TMEM120B 236.6211596 256.982229 216.2600901 0.84153714 -0.24890115 0.470331572 1 5.702565176 4.718616957 144404 transmembrane protein 120B "GO:0003674,GO:0005216,GO:0005515,GO:0005575,GO:0005637,GO:0008150,GO:0016020,GO:0016021,GO:0034220,GO:0045444,GO:0051291" molecular_function|ion channel activity|protein binding|cellular_component|nuclear inner membrane|biological_process|membrane|integral component of membrane|ion transmembrane transport|fat cell differentiation|protein heterooligomerization TMEM121 43.07841091 33.29324424 52.86357758 1.587816951 0.667044604 0.297909022 1 0.810213979 1.264944131 80757 transmembrane protein 121 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane TMEM121B 7.44644345 6.242483296 8.650403604 1.385731158 0.470647391 0.809847313 1 0.065787887 0.089638813 27439 transmembrane protein 121B TMEM123 8214.564577 8038.237657 8390.891496 1.043872034 0.061944866 0.802464106 1 129.8383687 133.2666534 114908 transmembrane protein 123 "GO:0005515,GO:0009897,GO:0016021,GO:0031410,GO:0038023,GO:0070267" protein binding|external side of plasma membrane|integral component of membrane|cytoplasmic vesicle|signaling receptor activity|oncosis TMEM126A 386.0802963 357.9023756 414.258217 1.15746149 0.210964194 0.473318356 1 25.16547034 28.64064412 84233 transmembrane protein 126A "GO:0003674,GO:0005739,GO:0005743,GO:0016021,GO:0021554,GO:0032981" molecular_function|mitochondrion|mitochondrial inner membrane|integral component of membrane|optic nerve development|mitochondrial respiratory chain complex I assembly TMEM126B 710.6566723 690.8348181 730.4785266 1.057385221 0.080501067 0.75721319 1 27.90960223 29.01737093 55863 transmembrane protein 126B "GO:0003674,GO:0005515,GO:0005739,GO:0005743,GO:0016021,GO:0032981" molecular_function|protein binding|mitochondrion|mitochondrial inner membrane|integral component of membrane|mitochondrial respiratory chain complex I assembly TMEM127 1497.991356 1615.76276 1380.219953 0.854221911 -0.22731719 0.341150679 1 13.53268814 11.36647914 55654 transmembrane protein 127 "GO:0003674,GO:0005737,GO:0005769,GO:0005886,GO:0007032,GO:0008285,GO:0016020,GO:0016021,GO:0031267,GO:0032006,GO:0032007" molecular_function|cytoplasm|early endosome|plasma membrane|endosome organization|negative regulation of cell population proliferation|membrane|integral component of membrane|small GTPase binding|regulation of TOR signaling|negative regulation of TOR signaling TMEM128 484.4396516 454.6608667 514.2184365 1.130993393 0.177590502 0.522213474 1 13.88124418 15.43688399 85013 transmembrane protein 128 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane TMEM129 721.7445644 704.3601985 739.1289302 1.049362147 0.069512654 0.789814488 1 9.756140472 10.06641006 92305 "transmembrane protein 129, E3 ubiquitin ligase" "GO:0000209,GO:0005783,GO:0005789,GO:0006986,GO:0016021,GO:0016567,GO:0030433,GO:0030970,GO:0046872,GO:0061630" "protein polyubiquitination|endoplasmic reticulum|endoplasmic reticulum membrane|response to unfolded protein|integral component of membrane|protein ubiquitination|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|metal ion binding|ubiquitin protein ligase activity" TMEM131 1431.62252 1538.772132 1324.472907 0.86073362 -0.216361274 0.366152671 1 12.20229429 10.32717271 23505 transmembrane protein 131 "GO:0003674,GO:0005575,GO:0008150,GO:0016020,GO:0016021" molecular_function|cellular_component|biological_process|membrane|integral component of membrane TMEM131L 440.647305 503.5603192 377.7342907 0.750127197 -0.414792845 0.140967459 1 4.33453044 3.197040571 23240 transmembrane 131 like "GO:0005737,GO:0005783,GO:0005886,GO:0016020,GO:0016021,GO:0016055,GO:0033088,GO:0090090" cytoplasm|endoplasmic reticulum|plasma membrane|membrane|integral component of membrane|Wnt signaling pathway|negative regulation of immature T cell proliferation in thymus|negative regulation of canonical Wnt signaling pathway TMEM132A 4114.052582 4411.354862 3816.750301 0.865210444 -0.208877014 0.380910702 1 43.66207368 37.14473721 54972 transmembrane protein 132A "GO:0000139,GO:0003674,GO:0005783,GO:0005788,GO:0005789,GO:0005794,GO:0008150,GO:0016021,GO:0043687,GO:0044267,GO:0070062" Golgi membrane|molecular_function|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi apparatus|biological_process|integral component of membrane|post-translational protein modification|cellular protein metabolic process|extracellular exosome TMEM132B 2.080827765 4.161655531 0 0 #NAME? 0.234194363 1 0.013820778 0 114795 transmembrane protein 132B "GO:0003674,GO:0005575,GO:0008150,GO:0016021" molecular_function|cellular_component|biological_process|integral component of membrane TMEM134 266.0207046 246.5780902 285.4633189 1.157699448 0.211260762 0.524736931 1 2.914600107 3.31776775 80194 transmembrane protein 134 "GO:0005515,GO:0005829,GO:0016021,GO:0016032,GO:0048471" protein binding|cytosol|integral component of membrane|viral process|perinuclear region of cytoplasm TMEM135 289.7866776 302.7604398 276.8129153 0.914296846 -0.129265451 0.693094629 1 3.971919426 3.570744946 65084 transmembrane protein 135 "GO:0005777,GO:0005778,GO:0005811,GO:0007031,GO:0009409,GO:0016021,GO:0031966,GO:0032094,GO:0090140" peroxisome|peroxisomal membrane|lipid droplet|peroxisome organization|response to cold|integral component of membrane|mitochondrial membrane|response to food|regulation of mitochondrial fission TMEM138 400.5020517 446.3375557 354.6665478 0.794615069 -0.331671941 0.251761037 1 6.94062209 5.422834791 51524 transmembrane protein 138 "GO:0005774,GO:0005929,GO:0016021,GO:0060271" vacuolar membrane|cilium|integral component of membrane|cilium assembly TMEM139 321.4702256 289.2350594 353.7053918 1.222899439 0.290305773 0.347989812 1 7.09698553 8.53366999 135932 transmembrane protein 139 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM140 49.83607073 59.30359131 40.36855015 0.680710042 -0.554887701 0.361373799 1 1.584839095 1.060763365 55281 transmembrane protein 140 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM141 463.4527364 458.8225222 468.0829506 1.020183029 0.028828007 0.925684943 1 29.18535725 29.2761718 85014 transmembrane protein 141 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM143 49.999617 50.98028025 49.01895376 0.961527742 -0.056599612 0.961269656 1 1.202264189 1.136666103 55260 transmembrane protein 143 "GO:0003674,GO:0005515,GO:0005739,GO:0008150,GO:0016021" molecular_function|protein binding|mitochondrion|biological_process|integral component of membrane TMEM144 161.1559401 193.5169822 128.7948981 0.665548298 -0.587384731 0.136657733 1 2.764359119 1.809027702 55314 transmembrane protein 144 "GO:0005515,GO:0015144,GO:0016021,GO:0034219" protein binding|carbohydrate transmembrane transporter activity|integral component of membrane|carbohydrate transmembrane transport TMEM145 6.524916457 7.282897178 5.766935736 0.791846376 -0.336707531 0.922510643 1 0.172284945 0.134140352 284339 transmembrane protein 145 "GO:0007186,GO:0016021,GO:0019236" G protein-coupled receptor signaling pathway|integral component of membrane|response to pheromone TMEM147 725.6042794 666.9052988 784.3032601 1.176033931 0.233929685 0.359778421 1 41.00404387 47.41521457 10430 transmembrane protein 147 "GO:0005515,GO:0005789,GO:0005886,GO:0016021,GO:0032991" protein binding|endoplasmic reticulum membrane|plasma membrane|integral component of membrane|protein-containing complex TMEM14A 468.3283277 384.9531366 551.7035187 1.433170603 0.519210356 0.061471386 1 20.50323492 28.89292149 28978 transmembrane protein 14A "GO:0005515,GO:0005789,GO:0006839,GO:0006915,GO:0016021,GO:0031966,GO:0043066,GO:1901029" protein binding|endoplasmic reticulum membrane|mitochondrial transport|apoptotic process|integral component of membrane|mitochondrial membrane|negative regulation of apoptotic process|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway TMEM14B 2048.836286 1858.179194 2239.493377 1.20520851 0.269282765 0.255081129 1 56.18561383 66.58225473 81853 transmembrane protein 14B "GO:0005515,GO:0005743,GO:0006839,GO:0016021,GO:0021987,GO:0031966,GO:0042802,GO:0061351,GO:2000045" protein binding|mitochondrial inner membrane|mitochondrial transport|integral component of membrane|cerebral cortex development|mitochondrial membrane|identical protein binding|neural precursor cell proliferation|regulation of G1/S transition of mitotic cell cycle TMEM14C 2589.528099 2351.335375 2827.720823 1.202602084 0.266159364 0.260355134 1 121.8315023 144.0630915 51522 transmembrane protein 14C "GO:0005515,GO:0005743,GO:0006783,GO:0006839,GO:0016021,GO:0030218,GO:0031966,GO:0070453" protein binding|mitochondrial inner membrane|heme biosynthetic process|mitochondrial transport|integral component of membrane|erythrocyte differentiation|mitochondrial membrane|regulation of heme biosynthetic process TMEM150A 123.1707726 142.5367019 103.8048432 0.72826747 -0.457459691 0.295100998 1 3.057444457 2.189377578 129303 transmembrane protein 150A "GO:0005515,GO:0005764,GO:0005887,GO:0009056,GO:0010506,GO:0046854,GO:0072659" protein binding|lysosome|integral component of plasma membrane|catabolic process|regulation of autophagy|phosphatidylinositol phosphorylation|protein localization to plasma membrane TMEM154 340.167493 401.5997587 278.7352272 0.694062238 -0.526863057 0.081648051 1 1.671682475 1.140836439 201799 transmembrane protein 154 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM156 569.0692224 733.4917873 404.6466575 0.551671695 -0.858118134 0.00128777 0.222914621 5.362343642 2.908750844 80008 transmembrane protein 156 GO:0016021 integral component of membrane TMEM158 500.7447043 441.1354862 560.3539223 1.270253561 0.345116509 0.206897079 1 12.92128986 16.13865987 25907 transmembrane protein 158 "GO:0016021,GO:0042277" integral component of membrane|peptide binding TMEM159 1377.685159 1321.325631 1434.044686 1.085307552 0.118103929 0.623929784 1 24.77748434 26.44120322 57146 transmembrane protein 159 "GO:0005515,GO:0005789,GO:0005811,GO:0016021,GO:0140042" protein binding|endoplasmic reticulum membrane|lipid droplet|integral component of membrane|lipid droplet formation TMEM160 258.9806116 225.7698125 292.1914106 1.294200528 0.372061171 0.262256803 1 18.39529763 23.40882259 54958 transmembrane protein 160 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM161A 386.7489583 388.0743782 385.4235384 0.993169248 -0.009888504 0.982972513 1 7.968763492 7.781895235 54929 transmembrane protein 161A "GO:0005515,GO:0016021,GO:0032526,GO:0034599,GO:0034644,GO:0045739,GO:1902230" protein binding|integral component of membrane|response to retinoic acid|cellular response to oxidative stress|cellular response to UV|positive regulation of DNA repair|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage TMEM161B 750.470417 676.2690237 824.6718102 1.219443419 0.28622282 0.259688059 1 2.295150071 2.751971427 153396 transmembrane protein 161B GO:0016021 integral component of membrane TMEM164 727.5014393 729.3301317 725.6727468 0.994985282 -0.00725291 0.983379405 1 2.779817789 2.719594567 84187 transmembrane protein 164 GO:0016021 integral component of membrane TMEM165 1409.724753 1418.084122 1401.365384 0.988210334 -0.017109952 0.946197606 1 22.5979526 21.95784237 55858 transmembrane protein 165 "GO:0005384,GO:0005765,GO:0005794,GO:0006487,GO:0006874,GO:0010008,GO:0015085,GO:0016021,GO:0031901,GO:0031902,GO:0032468,GO:0032472,GO:0032588,GO:0035751,GO:0043231,GO:0046873,GO:0070588,GO:0071421" manganese ion transmembrane transporter activity|lysosomal membrane|Golgi apparatus|protein N-linked glycosylation|cellular calcium ion homeostasis|endosome membrane|calcium ion transmembrane transporter activity|integral component of membrane|early endosome membrane|late endosome membrane|Golgi calcium ion homeostasis|Golgi calcium ion transport|trans-Golgi network membrane|regulation of lysosomal lumen pH|intracellular membrane-bounded organelle|metal ion transmembrane transporter activity|calcium ion transmembrane transport|manganese ion transmembrane transport TMEM167A 1983.219171 2002.796724 1963.641618 0.980449785 -0.028484352 0.906315506 1 23.60547265 22.75669742 153339 transmembrane protein 167A "GO:0000139,GO:0005515,GO:0005794,GO:0009306,GO:0016021,GO:0045054,GO:0046907" Golgi membrane|protein binding|Golgi apparatus|protein secretion|integral component of membrane|constitutive secretory pathway|intracellular transport TMEM167B 1364.620849 1243.29459 1485.947108 1.195168965 0.257214591 0.283889823 1 23.96256669 28.16007587 56900 transmembrane protein 167B "GO:0000139,GO:0003674,GO:0005515,GO:0005794,GO:0016021,GO:0045054" Golgi membrane|molecular_function|protein binding|Golgi apparatus|integral component of membrane|constitutive secretory pathway TMEM168 724.7318279 744.93634 704.5273157 0.945755064 -0.080461499 0.756517161 1 3.473646425 3.23024501 64418 transmembrane protein 168 "GO:0016021,GO:0030133" integral component of membrane|transport vesicle TMEM169 33.26367612 40.57614142 25.95121081 0.639568227 -0.644829827 0.363625167 1 0.566729676 0.356396978 92691 transmembrane protein 169 GO:0016021 integral component of membrane TMEM17 94.95568045 95.7180772 94.19328369 0.984069953 -0.023167222 0.986217494 1 1.050873865 1.016828573 200728 transmembrane protein 17 "GO:0005515,GO:0007224,GO:0016021,GO:0035869,GO:0036038,GO:0060170,GO:0060271,GO:1905515" protein binding|smoothened signaling pathway|integral component of membrane|ciliary transition zone|MKS complex|ciliary membrane|cilium assembly|non-motile cilium assembly TMEM170A 623.6280133 601.3592242 645.8968024 1.07406152 0.10307663 0.697327961 1 5.446951212 5.752462836 124491 transmembrane protein 170A "GO:0005515,GO:0005635,GO:0005789,GO:0006998,GO:0016021,GO:0051292,GO:0071786" protein binding|nuclear envelope|endoplasmic reticulum membrane|nuclear envelope organization|integral component of membrane|nuclear pore complex assembly|endoplasmic reticulum tubular network organization TMEM170B 191.4820426 169.5874629 213.3766222 1.258209885 0.331372602 0.373201671 1 1.017947498 1.259359292 100113407 transmembrane protein 170B "GO:0005515,GO:0005886,GO:0016021,GO:0016055,GO:0090090" protein binding|plasma membrane|integral component of membrane|Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway TMEM171 103.8438578 101.9605605 105.7271552 1.036941683 0.052334759 0.931927079 1 4.356643489 4.441989559 134285 transmembrane protein 171 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM175 221.2130961 230.9718819 211.4543103 0.915498062 -0.127371263 0.725492172 1 5.016908763 4.516113113 84286 transmembrane protein 175 "GO:0005267,GO:0005764,GO:0005765,GO:0005768,GO:0010008,GO:0016021,GO:0022841,GO:0035751,GO:0071805,GO:0090385" potassium channel activity|lysosome|lysosomal membrane|endosome|endosome membrane|integral component of membrane|potassium ion leak channel activity|regulation of lysosomal lumen pH|potassium ion transmembrane transport|phagosome-lysosome fusion TMEM177 180.1463159 174.7895323 185.5030995 1.061294101 0.085824505 0.834060278 1 7.109905555 7.419433739 80775 transmembrane protein 177 "GO:0005515,GO:0031305" protein binding|integral component of mitochondrial inner membrane TMEM178A 29.62222753 33.29324424 25.95121081 0.779473776 -0.359427608 0.649946143 1 0.192398403 0.147459973 130733 transmembrane protein 178A "GO:0005789,GO:0016020,GO:0016021,GO:0045671,GO:0051480" endoplasmic reticulum membrane|membrane|integral component of membrane|negative regulation of osteoclast differentiation|regulation of cytosolic calcium ion concentration TMEM178B 337.4771395 419.2867947 255.6674843 0.609767557 -0.713668703 0.018735538 0.785915575 1.628926666 0.976645661 100507421 transmembrane protein 178B "GO:0016020,GO:0016021" membrane|integral component of membrane TMEM179B 551.6803252 554.5405994 548.8200509 0.989684166 -0.014959897 0.962851926 1 29.56524734 28.77062639 374395 transmembrane protein 179B "GO:0005515,GO:0005730,GO:0005886,GO:0016021,GO:0016607,GO:0030667,GO:0035577,GO:0043312,GO:0101003" protein binding|nucleolus|plasma membrane|integral component of membrane|nuclear speck|secretory granule membrane|azurophil granule membrane|neutrophil degranulation|ficolin-1-rich granule membrane TMEM18 471.6470997 497.3178359 445.9763636 0.89676326 -0.157200923 0.57434584 1 3.903653312 3.442074184 129787 transmembrane protein 18 "GO:0003677,GO:0005737,GO:0016021,GO:0016477,GO:0031965" DNA binding|cytoplasm|integral component of membrane|cell migration|nuclear membrane TMEM181 1259.611431 1350.45722 1168.765642 0.865459213 -0.208462264 0.388039319 1 7.385123453 6.284569648 57583 transmembrane protein 181 "GO:0009405,GO:0015643,GO:0016021" pathogenesis|toxic substance binding|integral component of membrane TMEM182 130.8254217 129.0113214 132.6395219 1.028123117 0.040013036 0.944580511 1 1.405982665 1.421334406 130827 transmembrane protein 182 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM183A 824.3693708 850.0181421 798.7205994 0.939651238 -0.089802711 0.723725925 1 14.29234593 13.20509068 92703 transmembrane protein 183A "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM184A 28.66107157 33.29324424 24.0288989 0.721734978 -0.47045892 0.544841767 1 0.268277103 0.190384918 202915 transmembrane protein 184A "GO:0005215,GO:0005768,GO:0005886,GO:0006810,GO:0008201,GO:0016021,GO:0030658,GO:0030659,GO:0030667,GO:0031901,GO:0048471" transporter activity|endosome|plasma membrane|transport|heparin binding|integral component of membrane|transport vesicle membrane|cytoplasmic vesicle membrane|secretory granule membrane|early endosome membrane|perinuclear region of cytoplasm TMEM184B 2656.683255 2663.45954 2649.906971 0.994911667 -0.007359653 0.976938185 1 36.10463307 35.31983272 25829 transmembrane protein 184B "GO:0005215,GO:0006810,GO:0016021" transporter activity|transport|integral component of membrane TMEM184C 690.6504204 745.9767539 635.3240869 0.851667406 -0.231637957 0.36792527 1 9.560856942 8.006413672 55751 transmembrane protein 184C "GO:0005215,GO:0006810,GO:0016021" transporter activity|transport|integral component of membrane TMEM185A 347.4409437 340.2153396 354.6665478 1.042476651 0.060015071 0.851020094 1 6.050205727 6.201655782 84548 transmembrane protein 185A "GO:0005515,GO:0016021,GO:0030425" protein binding|integral component of membrane|dendrite TMEM185B 1004.223193 1054.979677 953.4667083 0.903777323 -0.145960737 0.554279855 1 9.507316175 8.448712966 79134 transmembrane protein 185B GO:0016021 integral component of membrane TMEM186 179.4229337 181.0320156 177.8138519 0.982223234 -0.025877145 0.961713983 1 6.713930472 6.484227163 25880 transmembrane protein 186 "GO:0005515,GO:0005739,GO:0016021" protein binding|mitochondrion|integral component of membrane TMEM187 339.5686425 297.5583704 381.5789145 1.282366596 0.35880875 0.237162791 1 8.881511936 11.19876881 8269 transmembrane protein 187 "GO:0003674,GO:0005515,GO:0008150,GO:0016021,GO:0030133" molecular_function|protein binding|biological_process|integral component of membrane|transport vesicle TMEM19 783.2686064 679.3902654 887.1469474 1.305798732 0.384932546 0.127113473 1 6.403710667 8.222031242 55266 transmembrane protein 19 "GO:0005515,GO:0016020,GO:0016021" protein binding|membrane|integral component of membrane TMEM191B 22.29970139 17.687036 26.91236677 1.521587153 0.605576971 0.477957666 1 0.674713799 1.009456488 728229 transmembrane protein 191B GO:0016021 integral component of membrane TMEM191C 4.845408743 1.040413883 8.650403604 8.314386946 3.055609892 0.118982446 1 0.050661475 0.414170576 645426 transmembrane protein 191C GO:0016021 integral component of membrane TMEM192 678.22459 773.0275148 583.4216653 0.754723026 -0.405980804 0.114645011 1 4.131289575 3.065804208 201931 transmembrane protein 192 "GO:0005634,GO:0005654,GO:0005764,GO:0005765,GO:0005768,GO:0005770,GO:0005783,GO:0005794,GO:0005886,GO:0016021,GO:0042803,GO:0048471" nucleus|nucleoplasm|lysosome|lysosomal membrane|endosome|late endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of membrane|protein homodimerization activity|perinuclear region of cytoplasm TMEM198 30.06820696 19.76786377 40.36855015 2.042130127 1.030074799 0.159028594 1 0.411777735 0.826832334 130612 transmembrane protein 198 "GO:0005886,GO:0007275,GO:0016021,GO:0016055,GO:0031410,GO:0090263" plasma membrane|multicellular organism development|integral component of membrane|Wnt signaling pathway|cytoplasmic vesicle|positive regulation of canonical Wnt signaling pathway TMEM199 386.104834 396.3976893 375.8119788 0.948068036 -0.0769375 0.799837478 1 6.864054552 6.398695001 147007 transmembrane protein 199 "GO:0005515,GO:0005764,GO:0005783,GO:0005789,GO:0006879,GO:0007042,GO:0012505,GO:0016021,GO:0016471,GO:0030663,GO:0033116,GO:0036295,GO:0070072,GO:1905146" protein binding|lysosome|endoplasmic reticulum|endoplasmic reticulum membrane|cellular iron ion homeostasis|lysosomal lumen acidification|endomembrane system|integral component of membrane|vacuolar proton-transporting V-type ATPase complex|COPI-coated vesicle membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|cellular response to increased oxygen levels|vacuolar proton-transporting V-type ATPase complex assembly|lysosomal protein catabolic process TMEM200B 481.0705753 467.1458333 494.9953173 1.059616253 0.083541877 0.768144369 1 8.951782602 9.326728103 399474 transmembrane protein 200B GO:0016021 integral component of membrane TMEM201 308.8066215 310.043337 307.5699059 0.992022305 -0.011555535 0.982146706 1 3.844433797 3.7499459 199953 transmembrane protein 201 "GO:0000922,GO:0005521,GO:0005639,GO:0005737,GO:0010761,GO:0030473,GO:0031965,GO:0051015" spindle pole|lamin binding|integral component of nuclear inner membrane|cytoplasm|fibroblast migration|nuclear migration along microtubule|nuclear membrane|actin filament binding TMEM203 743.0535417 696.0368875 790.0701958 1.135098168 0.182817073 0.473593173 1 23.70530276 26.45757938 94107 transmembrane protein 203 "GO:0005515,GO:0005783,GO:0005789,GO:0006874,GO:0007283,GO:0016021" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|cellular calcium ion homeostasis|spermatogenesis|integral component of membrane TMEM205 1041.332107 994.6356718 1088.028542 1.093896562 0.129476325 0.599137193 1 32.78682998 35.2652417 374882 transmembrane protein 205 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane TMEM208 336.288885 287.1542316 385.4235384 1.34221786 0.42461886 0.162606359 1 17.16113502 22.64853944 29100 transmembrane protein 208 "GO:0005515,GO:0005773,GO:0005789,GO:0006624,GO:0006914,GO:0016021,GO:0043231" protein binding|vacuole|endoplasmic reticulum membrane|vacuolar protein processing|autophagy|integral component of membrane|intracellular membrane-bounded organelle TMEM209 1130.990754 1216.243829 1045.73768 0.859809238 -0.217911483 0.370938867 1 16.81136954 14.21269317 84928 transmembrane protein 209 GO:0016021 integral component of membrane TMEM214 1565.594335 1611.601104 1519.587566 0.942905513 -0.084814886 0.723623983 1 26.91962095 24.95791459 54867 transmembrane protein 214 "GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005881,GO:0006915,GO:0016021" endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|cytoplasmic microtubule|apoptotic process|integral component of membrane TMEM216 203.9619787 207.0423626 200.8815948 0.970243926 -0.043580598 0.917949268 1 10.40439771 9.925880813 51259 transmembrane protein 216 "GO:0005515,GO:0005829,GO:0005856,GO:0005929,GO:0016021,GO:0035869,GO:0036038,GO:0060271,GO:0097711,GO:1905515" protein binding|cytosol|cytoskeleton|cilium|integral component of membrane|ciliary transition zone|MKS complex|cilium assembly|ciliary basal body-plasma membrane docking|non-motile cilium assembly TMEM217 6.886607545 4.161655531 9.61155956 2.309551929 1.207612985 0.417805055 1 0.053363745 0.12118398 221468 transmembrane protein 217 GO:0016021 integral component of membrane TMEM218 399.3477814 428.6505196 370.0450431 0.863279119 -0.212101002 0.466379665 1 4.99264304 4.237921728 219854 transmembrane protein 218 "GO:0005515,GO:0005929,GO:0016021" protein binding|cilium|integral component of membrane TMEM219 1317.578927 1206.880104 1428.277751 1.183446264 0.242994201 0.312559427 1 61.57645602 71.65300548 124446 transmembrane protein 219 "GO:0005515,GO:0005886,GO:0006915,GO:0016021,GO:0042981" protein binding|plasma membrane|apoptotic process|integral component of membrane|regulation of apoptotic process TMEM222 514.5669948 526.4494246 502.684565 0.954858229 -0.066641548 0.812402224 1 17.60378335 16.52783956 84065 transmembrane protein 222 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM223 189.6238973 209.1231904 170.1246042 0.813513814 -0.297761251 0.426040467 1 8.767101587 7.01281124 79064 transmembrane protein 223 "GO:0007399,GO:0016021" nervous system development|integral component of membrane TMEM225B 35.94899917 35.37407201 36.52392633 1.032505568 0.046149562 0.992801931 1 0.235833755 0.239425028 100289187 transmembrane protein 225B "GO:0005515,GO:0010923,GO:0016021" protein binding|negative regulation of phosphatase activity|integral component of membrane TMEM229B 51.39669156 62.42483296 40.36855015 0.64667454 -0.628888283 0.292837433 1 0.747140301 0.475071639 161145 transmembrane protein 229B "GO:0005515,GO:0009617,GO:0016021" protein binding|response to bacterium|integral component of membrane TMEM230 2530.990706 2517.801596 2544.179816 1.010476687 0.015036037 0.951079682 1 47.71677687 47.40984959 29058 transmembrane protein 230 "GO:0005769,GO:0005770,GO:0005776,GO:0005783,GO:0005802,GO:0008021,GO:0016021,GO:0048489,GO:0055037" early endosome|late endosome|autophagosome|endoplasmic reticulum|trans-Golgi network|synaptic vesicle|integral component of membrane|synaptic vesicle transport|recycling endosome TMEM231 244.2657478 268.4267817 220.1047139 0.819980452 -0.286338577 0.399382885 1 3.272143443 2.638195722 79583 transmembrane protein 231 "GO:0001701,GO:0001944,GO:0005515,GO:0007224,GO:0016021,GO:0032880,GO:0035869,GO:0036038,GO:0042733,GO:0043010,GO:0060170,GO:0060271,GO:0060563" in utero embryonic development|vasculature development|protein binding|smoothened signaling pathway|integral component of membrane|regulation of protein localization|ciliary transition zone|MKS complex|embryonic digit morphogenesis|camera-type eye development|ciliary membrane|cilium assembly|neuroepithelial cell differentiation TMEM232 9.408384325 7.282897178 11.53387147 1.583692752 0.663292469 0.627344635 1 0.021324126 0.033205753 642987 transmembrane protein 232 GO:0016021 integral component of membrane TMEM234 118.3851145 92.59683556 144.1733934 1.557001301 0.63877015 0.148308227 1 1.087287773 1.664579946 56063 transmembrane protein 234 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM237 755.6177662 723.0876484 788.1478839 1.089975587 0.124295822 0.626910341 1 7.06644549 7.573366295 65062 transmembrane protein 237 "GO:0005515,GO:0016020,GO:0016021,GO:0030111,GO:0032391,GO:0035869,GO:0060271,GO:0120199,GO:0120200" protein binding|membrane|integral component of membrane|regulation of Wnt signaling pathway|photoreceptor connecting cilium|ciliary transition zone|cilium assembly|cone photoreceptor outer segment|rod photoreceptor outer segment TMEM238 6.083967443 8.323311061 3.844623824 0.461910386 -1.11431511 0.492415049 1 0.639136423 0.290283582 388564 transmembrane protein 238 GO:0016021 integral component of membrane TMEM240 26.30284106 21.84869154 30.75699059 1.40772689 0.493367467 0.541187841 1 0.844333462 1.168701459 339453 transmembrane protein 240 "GO:0016021,GO:0097060" integral component of membrane|synaptic membrane TMEM241 450.6111091 424.4888641 476.7333542 1.123076232 0.167455859 0.554050826 1 2.814185155 3.10765703 85019 transmembrane protein 241 "GO:0005515,GO:0005794,GO:0015297,GO:0016021,GO:0055085" protein binding|Golgi apparatus|antiporter activity|integral component of membrane|transmembrane transport TMEM242 340.1133871 337.094098 343.1326763 1.017913628 0.025615151 0.943087725 1 4.162446195 4.166110072 729515 transmembrane protein 242 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM243 546.4140891 504.6007331 588.2274451 1.165728479 0.221231796 0.410893155 1 12.43862065 14.25741556 79161 transmembrane protein 243 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM245 4050.15326 3970.219376 4130.087143 1.040266734 0.056953496 0.81186712 1 26.49534965 27.10101423 23731 transmembrane protein 245 "GO:0003674,GO:0008150,GO:0016021" molecular_function|biological_process|integral component of membrane TMEM248 1695.394434 1701.076698 1689.712171 0.993319215 -0.009670675 0.970263066 1 18.36232543 17.93443483 55069 transmembrane protein 248 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM249 17.41466368 15.60620824 19.22311912 1.231761029 0.300722389 0.792076496 1 0.839591382 1.016870411 340393 transmembrane protein 249 GO:0016021 integral component of membrane TMEM25 494.358182 487.954111 500.7622531 1.026248661 0.03738034 0.899003254 1 6.661860855 6.722322435 84866 transmembrane protein 25 "GO:0005515,GO:0005576,GO:0005764,GO:0005770,GO:0005886,GO:0016021,GO:0031647,GO:0090394" protein binding|extracellular region|lysosome|late endosome|plasma membrane|integral component of membrane|regulation of protein stability|negative regulation of excitatory postsynaptic potential TMEM250 751.624073 794.8762063 708.3719396 0.891172655 -0.166223129 0.514277057 1 12.44750065 10.90724801 90120 transmembrane protein 250 "GO:0003924,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005940,GO:0008284,GO:0015630,GO:0016021,GO:0016032,GO:0031105,GO:0032153,GO:0034613,GO:0048524,GO:0060090,GO:0060271,GO:0061640" GTPase activity|protein binding|nucleus|nucleoplasm|cytoplasm|septin ring|positive regulation of cell population proliferation|microtubule cytoskeleton|integral component of membrane|viral process|septin complex|cell division site|cellular protein localization|positive regulation of viral process|molecular adaptor activity|cilium assembly|cytoskeleton-dependent cytokinesis TMEM251 328.2473927 366.2256867 290.2690987 0.79259623 -0.335341989 0.274097011 1 8.036509788 6.263118936 26175 transmembrane protein 251 GO:0016021 integral component of membrane TMEM253 4.404459729 2.080827765 6.728091692 3.233372701 1.693039812 0.389066599 1 0.044868668 0.142649457 643382 transmembrane protein 253 GO:0016021 integral component of membrane TMEM254 421.6128842 432.8121752 410.4135932 0.948248725 -0.076662568 0.795136092 1 6.833843288 6.371746094 80195 transmembrane protein 254 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM255A 197.8239054 134.2133909 261.43442 1.947901162 0.961920476 0.008710347 0.573019799 1.69091643 3.238621832 55026 transmembrane protein 255A GO:0016021 integral component of membrane TMEM255B 34.02668726 35.37407201 32.6793025 0.923820772 -0.11431511 0.912013575 1 0.423379504 0.384581803 348013 transmembrane protein 255B "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM256 483.5130942 468.1862472 498.8399412 1.06547329 0.091494427 0.745677641 1 56.02295857 58.69211851 254863 transmembrane protein 256 "GO:0003674,GO:0008150,GO:0016021,GO:0070062" molecular_function|biological_process|integral component of membrane|extracellular exosome TMEM258 683.0209234 697.0773014 668.9645454 0.959670533 -0.059388899 0.822435344 1 64.36286228 60.73355288 746 transmembrane protein 258 "GO:0005515,GO:0005783,GO:0006487,GO:0016021,GO:0032991,GO:0034998,GO:0043227" protein binding|endoplasmic reticulum|protein N-linked glycosylation|integral component of membrane|protein-containing complex|oligosaccharyltransferase I complex|membrane-bounded organelle TMEM259 1705.97218 1688.591732 1723.352629 1.020585732 0.029397378 0.903945098 1 32.25377137 32.3669051 91304 transmembrane protein 259 "GO:0005783,GO:0005789,GO:0016021,GO:0034976,GO:1901215,GO:1904294" endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|response to endoplasmic reticulum stress|negative regulation of neuron death|positive regulation of ERAD pathway TMEM260 280.3782933 295.4775427 265.2790439 0.897797651 -0.155537773 0.636368346 1 3.095621003 2.732734427 54916 transmembrane protein 260 GO:0016021 integral component of membrane TMEM263 2387.043067 2056.898246 2717.187888 1.321012302 0.401643902 0.089420791 1 29.19491462 37.92147752 90488 transmembrane protein 263 GO:0016021 integral component of membrane TMEM265 181.9843395 185.1936711 178.7750078 0.965340806 -0.05088973 0.907480819 1 5.99359967 5.689047701 100862671 transmembrane protein 265 GO:0016021 integral component of membrane TMEM267 328.3562188 394.3168615 262.395576 0.665443458 -0.587612007 0.054662779 1 4.392395361 2.873980141 64417 transmembrane protein 267 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM268 351.3346429 417.2059669 285.4633189 0.684226357 -0.547454416 0.067774706 1 3.994530977 2.687427591 203197 transmembrane protein 268 "GO:0003674,GO:0005575,GO:0008150,GO:0016021" molecular_function|cellular_component|biological_process|integral component of membrane TMEM269 3.522561699 4.161655531 2.883467868 0.692865579 -0.529352609 0.940314863 1 0.065246741 0.044450739 100129924 transmembrane protein 269 GO:0016021 integral component of membrane TMEM270 7.927021428 6.242483296 9.61155956 1.539701286 0.622650484 0.695278173 1 0.296133209 0.448326865 135886 transmembrane protein 270 GO:0016021 integral component of membrane TMEM30A 4037.120361 3615.438242 4458.80248 1.233267499 0.302485758 0.204248415 1 43.67344819 52.9597526 55754 transmembrane protein 30A "GO:0005515,GO:0005783,GO:0005794,GO:0005886,GO:0006855,GO:0010976,GO:0015247,GO:0015917,GO:0016020,GO:0016021,GO:0016324,GO:0030658,GO:0035577,GO:0035579,GO:0036010,GO:0043312,GO:0045332,GO:0061092,GO:0070863,GO:0140331,GO:1990531" protein binding|endoplasmic reticulum|Golgi apparatus|plasma membrane|drug transmembrane transport|positive regulation of neuron projection development|aminophospholipid flippase activity|aminophospholipid transport|membrane|integral component of membrane|apical plasma membrane|transport vesicle membrane|azurophil granule membrane|specific granule membrane|protein localization to endosome|neutrophil degranulation|phospholipid translocation|positive regulation of phospholipid translocation|positive regulation of protein exit from endoplasmic reticulum|aminophospholipid translocation|phospholipid-translocating ATPase complex TMEM33 1691.540364 1625.126485 1757.954244 1.081733797 0.113345512 0.634554934 1 11.41935663 12.14599824 55161 transmembrane protein 33 "GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0030176,GO:0034976,GO:0042470,GO:0061024,GO:0071786,GO:1903371,GO:1903896,GO:1903899" protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of endoplasmic reticulum membrane|response to endoplasmic reticulum stress|melanosome|membrane organization|endoplasmic reticulum tubular network organization|regulation of endoplasmic reticulum tubular network organization|positive regulation of IRE1-mediated unfolded protein response|positive regulation of PERK-mediated unfolded protein response TMEM35B 331.0817852 289.2350594 372.9285109 1.289361365 0.36665666 0.23053367 1 16.68750652 21.15618127 100506144 transmembrane protein 35B GO:0016021 integral component of membrane TMEM37 18.53433549 19.76786377 17.30080721 0.875198626 -0.192317622 0.886403646 1 0.459483692 0.395410236 140738 transmembrane protein 37 "GO:0005244,GO:0005262,GO:0016021,GO:0034765,GO:0070588" voltage-gated ion channel activity|calcium channel activity|integral component of membrane|regulation of ion transmembrane transport|calcium ion transmembrane transport TMEM38A 78.26439894 73.86938567 82.65941222 1.118994174 0.162202525 0.771027708 1 1.498393518 1.648636421 79041 transmembrane protein 38A "GO:0005267,GO:0007029,GO:0010881,GO:0014808,GO:0016021,GO:0031965,GO:0033017,GO:0042802,GO:0070062,GO:0071313,GO:0071805" potassium channel activity|endoplasmic reticulum organization|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|integral component of membrane|nuclear membrane|sarcoplasmic reticulum membrane|identical protein binding|extracellular exosome|cellular response to caffeine|potassium ion transmembrane transport TMEM38B 615.3002862 496.277422 734.3231504 1.47966262 0.565268262 0.030893659 0.895820653 7.288226168 10.60365825 55151 transmembrane protein 38B "GO:0005267,GO:0005515,GO:0005634,GO:0007029,GO:0008654,GO:0010881,GO:0014808,GO:0016021,GO:0030282,GO:0031965,GO:0033017,GO:0048286,GO:0060348,GO:0060487,GO:0061033,GO:0070278,GO:0071313,GO:0071805" potassium channel activity|protein binding|nucleus|endoplasmic reticulum organization|phospholipid biosynthetic process|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|integral component of membrane|bone mineralization|nuclear membrane|sarcoplasmic reticulum membrane|lung alveolus development|bone development|lung epithelial cell differentiation|secretion by lung epithelial cell involved in lung growth|extracellular matrix constituent secretion|cellular response to caffeine|potassium ion transmembrane transport TMEM39A 1064.721912 990.4740163 1138.969808 1.149923965 0.201538471 0.410665946 1 9.539754166 10.78642398 55254 transmembrane protein 39A "GO:0005515,GO:0005789,GO:0006914,GO:0016020,GO:0016021,GO:0045070,GO:1901097,GO:1902902" protein binding|endoplasmic reticulum membrane|autophagy|membrane|integral component of membrane|positive regulation of viral genome replication|negative regulation of autophagosome maturation|negative regulation of autophagosome assembly TMEM39B 258.2767367 282.9925761 233.5608973 0.825325175 -0.276965448 0.406060449 1 3.556108704 2.885833691 55116 transmembrane protein 39B "GO:0005789,GO:0016020,GO:0016021,GO:0045070,GO:1901097,GO:1902902" endoplasmic reticulum membrane|membrane|integral component of membrane|positive regulation of viral genome replication|negative regulation of autophagosome maturation|negative regulation of autophagosome assembly TMEM40 1121.633903 882.2709725 1360.996834 1.542606383 0.625369986 0.010337034 0.610531935 18.55939308 28.15075667 55287 transmembrane protein 40 GO:0016021 integral component of membrane TMEM41A 543.6048487 519.1665274 568.04317 1.094144441 0.129803205 0.632622133 1 9.877705305 10.62678519 90407 transmembrane protein 41A "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM41B 876.6391283 733.4917873 1019.786469 1.390317502 0.475414384 0.056314376 1 9.882632816 13.51007712 440026 transmembrane protein 41B "GO:0000045,GO:0005515,GO:0005789,GO:0007399,GO:0016021,GO:0044233" autophagosome assembly|protein binding|endoplasmic reticulum membrane|nervous system development|integral component of membrane|mitochondria-associated endoplasmic reticulum membrane TMEM42 359.6831061 371.4277561 347.9384561 0.936759438 -0.094249487 0.759208407 1 20.28906519 18.68793408 131616 transmembrane protein 42 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM43 1827.325051 1770.784428 1883.865674 1.063859408 0.089307507 0.707843937 1 26.94710875 28.18821609 79188 transmembrane protein 43 "GO:0005515,GO:0005639,GO:0005783,GO:0005794,GO:0042802,GO:0071763" protein binding|integral component of nuclear inner membrane|endoplasmic reticulum|Golgi apparatus|identical protein binding|nuclear membrane organization TMEM44 776.8072422 812.5632423 741.0512421 0.911992081 -0.132906798 0.601389475 1 15.75190949 14.12522757 93109 transmembrane protein 44 GO:0016021 integral component of membrane TMEM45A 72.33894735 69.70773014 74.97016457 1.075492839 0.104997918 0.866816679 1 1.760612134 1.861840153 55076 transmembrane protein 45A "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM47 904.6454004 900.9984224 908.2923784 1.008095415 0.011632194 0.967565998 1 11.9021361 11.79771037 83604 transmembrane protein 47 "GO:0003674,GO:0005515,GO:0005886,GO:0005911,GO:0005912,GO:0008150,GO:0016021,GO:0098609" molecular_function|protein binding|plasma membrane|cell-cell junction|adherens junction|biological_process|integral component of membrane|cell-cell adhesion TMEM50A 2490.618968 2227.526123 2753.711814 1.236219762 0.305935233 0.195666498 1 45.25275034 55.0062249 23585 transmembrane protein 50A "GO:0005515,GO:0005783,GO:0016021,GO:0032511,GO:0043025,GO:0097386" protein binding|endoplasmic reticulum|integral component of membrane|late endosome to vacuole transport via multivesicular body sorting pathway|neuronal cell body|glial cell projection TMEM50B 599.3368029 556.6214272 642.0521786 1.153480889 0.205994101 0.435439414 1 9.277283743 10.52209992 757 transmembrane protein 50B "GO:0000139,GO:0003674,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0008150,GO:0016021,GO:0032511" Golgi membrane|molecular_function|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|biological_process|integral component of membrane|late endosome to vacuole transport via multivesicular body sorting pathway TMEM51 229.8534389 255.9418151 203.7650627 0.796138226 -0.328909161 0.34260356 1 4.864367618 3.807904466 55092 transmembrane protein 51 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane TMEM52 15.13066068 18.72744989 11.53387147 0.615880514 -0.699277611 0.488765132 1 1.068930033 0.647316865 339456 transmembrane protein 52 GO:0016021 integral component of membrane TMEM53 51.36209301 48.89945248 53.82473354 1.100722622 0.13845096 0.846163358 1 0.987390808 1.068656546 79639 transmembrane protein 53 "GO:0005634,GO:0016021" nucleus|integral component of membrane TMEM54 750.1584157 655.4607461 844.8560853 1.288949934 0.366196227 0.148994902 1 32.27005104 40.89845286 113452 transmembrane protein 54 "GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016021" molecular_function|protein binding|cellular_component|biological_process|integral component of membrane TMEM59 2224.464286 2015.281691 2433.646881 1.207596383 0.272138341 0.249757723 1 15.61665165 18.54303871 9528 transmembrane protein 59 "GO:0000137,GO:0000138,GO:0000139,GO:0004175,GO:0005515,GO:0005764,GO:0005765,GO:0005770,GO:0005797,GO:0005886,GO:0006508,GO:0006914,GO:0010508,GO:0010955,GO:0016021,GO:0031902,GO:0070062,GO:0090285,GO:1903077" Golgi cis cisterna|Golgi trans cisterna|Golgi membrane|endopeptidase activity|protein binding|lysosome|lysosomal membrane|late endosome|Golgi medial cisterna|plasma membrane|proteolysis|autophagy|positive regulation of autophagy|negative regulation of protein processing|integral component of membrane|late endosome membrane|extracellular exosome|negative regulation of protein glycosylation in Golgi|negative regulation of protein localization to plasma membrane TMEM59L 87.07834882 65.54607461 108.610623 1.65701186 0.728583929 0.138886177 1 2.157972568 3.515950202 25789 transmembrane protein 59 like "GO:0000139,GO:0016020,GO:0016021" Golgi membrane|membrane|integral component of membrane TMEM60 597.0974593 548.2981162 645.8968024 1.178002958 0.236343161 0.370597381 1 33.36563595 38.64710493 85025 transmembrane protein 60 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM61 4.444088692 3.121241648 5.766935736 1.847641543 0.88568489 0.705170935 1 0.075033752 0.136315601 199964 transmembrane protein 61 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM62 286.2741767 273.6288511 298.9195023 1.092426844 0.127536671 0.698500532 1 3.803873112 4.085917219 80021 transmembrane protein 62 "GO:0016021,GO:0016787" integral component of membrane|hydrolase activity TMEM63A 1018.471955 1075.787955 961.155956 0.893443686 -0.162551296 0.509203525 1 12.8411599 11.28087058 9725 transmembrane protein 63A "GO:0003676,GO:0005227,GO:0005515,GO:0005765,GO:0005886,GO:0008381,GO:0016021,GO:0034451,GO:0035579,GO:0043231,GO:0043312,GO:0070062,GO:0070821,GO:0098655,GO:1990760" nucleic acid binding|calcium activated cation channel activity|protein binding|lysosomal membrane|plasma membrane|mechanosensitive ion channel activity|integral component of membrane|centriolar satellite|specific granule membrane|intracellular membrane-bounded organelle|neutrophil degranulation|extracellular exosome|tertiary granule membrane|cation transmembrane transport|osmolarity-sensing cation channel activity TMEM63B 771.555483 826.0886228 717.0223432 0.867972665 -0.204278487 0.420259241 1 10.70588429 9.136918937 55362 transmembrane protein 63B "GO:0005227,GO:0005886,GO:0008381,GO:0015629,GO:0016021,GO:0098655,GO:1990760" calcium activated cation channel activity|plasma membrane|mechanosensitive ion channel activity|actin cytoskeleton|integral component of membrane|cation transmembrane transport|osmolarity-sensing cation channel activity TMEM64 549.3862613 582.6317743 516.1407484 0.885878133 -0.174819849 0.516393679 1 6.222530911 5.420161448 169200 transmembrane protein 64 "GO:0005783,GO:0016021,GO:0043462,GO:0045600,GO:0045668,GO:0045672,GO:0045780,GO:0051480,GO:0090090" endoplasmic reticulum|integral component of membrane|regulation of ATPase activity|positive regulation of fat cell differentiation|negative regulation of osteoblast differentiation|positive regulation of osteoclast differentiation|positive regulation of bone resorption|regulation of cytosolic calcium ion concentration|negative regulation of canonical Wnt signaling pathway TMEM65 1183.711522 1073.707127 1293.715917 1.204905774 0.268920329 0.26749747 1 6.340094708 7.511384775 157378 transmembrane protein 65 "GO:0003231,GO:0005515,GO:0005743,GO:0005886,GO:0014704,GO:0016021,GO:1903779" cardiac ventricle development|protein binding|mitochondrial inner membrane|plasma membrane|intercalated disc|integral component of membrane|regulation of cardiac conduction TMEM67 483.2948277 512.9240441 453.6656112 0.88446938 -0.177115897 0.523420682 1 6.210030291 5.400670725 91147 transmembrane protein 67 "GO:0005515,GO:0005789,GO:0005813,GO:0010826,GO:0016021,GO:0030433,GO:0030659,GO:0031005,GO:0035869,GO:0036038,GO:0051082,GO:0060170,GO:0060271,GO:0097711" protein binding|endoplasmic reticulum membrane|centrosome|negative regulation of centrosome duplication|integral component of membrane|ubiquitin-dependent ERAD pathway|cytoplasmic vesicle membrane|filamin binding|ciliary transition zone|MKS complex|unfolded protein binding|ciliary membrane|cilium assembly|ciliary basal body-plasma membrane docking TMEM68 455.3527223 384.9531366 525.7523079 1.365756654 0.449700452 0.10771752 1 4.59089193 6.165120555 137695 transmembrane protein 68 "GO:0016021,GO:0016746" "integral component of membrane|transferase activity, transferring acyl groups" TMEM69 1103.147414 1141.334029 1064.960799 0.933084243 -0.099920754 0.684260877 1 41.52072219 38.0940312 51249 transmembrane protein 69 "GO:0005515,GO:0016021" protein binding|integral component of membrane TMEM70 721.3086458 692.9156458 749.7016457 1.081952255 0.113636837 0.659445468 1 18.19863902 19.36057207 54968 transmembrane protein 70 "GO:0003674,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0032592,GO:0033615" molecular_function|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|integral component of mitochondrial membrane|mitochondrial proton-transporting ATP synthase complex assembly TMEM71 298.259058 247.6185041 348.899612 1.409020757 0.494692865 0.116642282 1 4.769016405 6.607198978 137835 transmembrane protein 71 "GO:0005739,GO:0016021" mitochondrion|integral component of membrane TMEM74 46.15499318 50.98028025 41.32970611 0.810699861 -0.302760199 0.644752998 1 0.433029422 0.345182431 157753 transmembrane protein 74 "GO:0000421,GO:0005515,GO:0005765,GO:0016021,GO:0016236,GO:0031410" autophagosome membrane|protein binding|lysosomal membrane|integral component of membrane|macroautophagy|cytoplasmic vesicle TMEM74B 179.3537366 153.9812546 204.7262186 1.329552867 0.410941145 0.280082129 1 1.641241573 2.145602659 55321 transmembrane protein 74B GO:0016021 integral component of membrane TMEM79 119.4846646 146.6983575 92.27097178 0.628984355 -0.668903962 0.128041179 1 3.632956713 2.246835335 84283 transmembrane protein 79 "GO:0002070,GO:0005515,GO:0005765,GO:0016021,GO:0031069,GO:0032588,GO:0042335,GO:0042802,GO:0045055,GO:0045684,GO:0061436,GO:0070268" epithelial cell maturation|protein binding|lysosomal membrane|integral component of membrane|hair follicle morphogenesis|trans-Golgi network membrane|cuticle development|identical protein binding|regulated exocytosis|positive regulation of epidermis development|establishment of skin barrier|cornification TMEM80 82.57953991 98.83931885 66.31976096 0.670985613 -0.575646261 0.251693955 1 2.378211356 1.569042963 283232 transmembrane protein 80 "GO:0005515,GO:0016021,GO:0035869,GO:1905515" protein binding|integral component of membrane|ciliary transition zone|non-motile cilium assembly TMEM81 47.64641691 27.05076095 68.24207288 2.522741338 1.334992291 0.030510387 0.895820653 1.083820867 2.688446575 388730 transmembrane protein 81 GO:0016021 integral component of membrane TMEM86A 59.76969242 55.14193578 64.39744905 1.1678489 0.223853626 0.711867871 1 0.815864643 0.936862697 144110 transmembrane protein 86A "GO:0005515,GO:0016021,GO:0047408,GO:0047409" protein binding|integral component of membrane|alkenylglycerophosphocholine hydrolase activity|alkenylglycerophosphoethanolamine hydrolase activity TMEM86B 44.39622754 42.65696919 46.13548589 1.081546269 0.113095386 0.892744716 1 1.51869516 1.615053418 255043 transmembrane protein 86B "GO:0005515,GO:0005737,GO:0005789,GO:0016020,GO:0016021,GO:0016803,GO:0036151,GO:0042802,GO:0046485,GO:0047408,GO:0047409" protein binding|cytoplasm|endoplasmic reticulum membrane|membrane|integral component of membrane|ether hydrolase activity|phosphatidylcholine acyl-chain remodeling|identical protein binding|ether lipid metabolic process|alkenylglycerophosphocholine hydrolase activity|alkenylglycerophosphoethanolamine hydrolase activity hsa00565 Ether lipid metabolism TMEM87A 662.123327 678.3498515 645.8968024 0.952158832 -0.070725841 0.78924406 1 6.804940756 6.370960719 25963 transmembrane protein 87A "GO:0005794,GO:0005829,GO:0006810,GO:0016020,GO:0016021,GO:0032580,GO:0042147" "Golgi apparatus|cytosol|transport|membrane|integral component of membrane|Golgi cisterna membrane|retrograde transport, endosome to Golgi" TMEM87B 1744.393881 1650.096418 1838.691344 1.114293276 0.156128993 0.511391274 1 18.68900957 20.4765589 84910 transmembrane protein 87B "GO:0000139,GO:0005794,GO:0005829,GO:0006810,GO:0016020,GO:0016021,GO:0042147" "Golgi membrane|Golgi apparatus|cytosol|transport|membrane|integral component of membrane|retrograde transport, endosome to Golgi" TMEM8B 286.5220113 254.9014012 318.1426214 1.248100716 0.319734358 0.320219912 1 2.222450465 2.727425527 51754 transmembrane protein 8B "GO:0005515,GO:0005634,GO:0005739,GO:0005783,GO:0005886,GO:0007160,GO:0007346,GO:0009986,GO:0016021,GO:0040008" protein binding|nucleus|mitochondrion|endoplasmic reticulum|plasma membrane|cell-matrix adhesion|regulation of mitotic cell cycle|cell surface|integral component of membrane|regulation of growth TMEM9 1748.064898 1683.389662 1812.740133 1.076839293 0.106802958 0.654006154 1 42.02030511 44.49193296 252839 transmembrane protein 9 "GO:0003674,GO:0005515,GO:0005764,GO:0005765,GO:0005770,GO:0007042,GO:0015031,GO:0015630,GO:0016021,GO:0032585,GO:0042176,GO:0043231,GO:0045171,GO:0048388,GO:0070070,GO:0072686,GO:0090263" molecular_function|protein binding|lysosome|lysosomal membrane|late endosome|lysosomal lumen acidification|protein transport|microtubule cytoskeleton|integral component of membrane|multivesicular body membrane|regulation of protein catabolic process|intracellular membrane-bounded organelle|intercellular bridge|endosomal lumen acidification|proton-transporting V-type ATPase complex assembly|mitotic spindle|positive regulation of canonical Wnt signaling pathway TMEM91 44.48051588 32.25283036 56.7082014 1.758239533 0.814131629 0.19608064 1 1.192844268 2.062210374 641649 transmembrane protein 91 "GO:0003674,GO:0005575,GO:0008150,GO:0016021" molecular_function|cellular_component|biological_process|integral component of membrane TMEM92 260.5016034 227.8506403 293.1525666 1.286599705 0.363563263 0.272479471 1 4.31817113 5.46278962 162461 transmembrane protein 92 "GO:0005515,GO:0005654,GO:0016021" protein binding|nucleoplasm|integral component of membrane TMEM94 1178.454118 1200.637621 1156.270615 0.96304713 -0.054321691 0.825806035 1 10.82727664 10.252693 9772 transmembrane protein 94 GO:0016021 integral component of membrane TMEM97 756.5688613 748.0575816 765.080141 1.022755681 0.03246155 0.903390651 1 15.22595662 15.31185004 27346 transmembrane protein 97 "GO:0001558,GO:0005515,GO:0005764,GO:0005783,GO:0005791,GO:0005886,GO:0016021,GO:0030867,GO:0031965,GO:0042632" regulation of cell growth|protein binding|lysosome|endoplasmic reticulum|rough endoplasmic reticulum|plasma membrane|integral component of membrane|rough endoplasmic reticulum membrane|nuclear membrane|cholesterol homeostasis TMEM98 976.2961785 889.5538697 1063.038487 1.195024297 0.257039951 0.297269643 1 11.06616669 13.00304667 26022 transmembrane protein 98 "GO:0005515,GO:0005615,GO:0005783,GO:0005789,GO:0005886,GO:0010955,GO:0016021,GO:0031642,GO:0045063,GO:0048715,GO:0070062,GO:1900181" protein binding|extracellular space|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|negative regulation of protein processing|integral component of membrane|negative regulation of myelination|T-helper 1 cell differentiation|negative regulation of oligodendrocyte differentiation|extracellular exosome|negative regulation of protein localization to nucleus TMEM9B 727.9524491 703.3197847 752.5851135 1.070046841 0.097673951 0.705261872 1 19.73442916 20.76340313 56674 TMEM9 domain family member B "GO:0005515,GO:0005765,GO:0016021,GO:0031901,GO:0043123" protein binding|lysosomal membrane|integral component of membrane|early endosome membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling TMF1 1454.631741 1385.831292 1523.43219 1.099291234 0.136573648 0.569018452 1 10.73740839 11.60602268 7110 TATA element modulatory factor 1 "GO:0000139,GO:0001675,GO:0001819,GO:0003677,GO:0005515,GO:0005634,GO:0005783,GO:0005794,GO:0005829,GO:0007289,GO:0010629,GO:0030317,GO:0030374,GO:0030521,GO:0032275,GO:0033327,GO:0042742,GO:0043066,GO:0045944,GO:0050681,GO:0061136,GO:2000845" Golgi membrane|acrosome assembly|positive regulation of cytokine production|DNA binding|protein binding|nucleus|endoplasmic reticulum|Golgi apparatus|cytosol|spermatid nucleus differentiation|negative regulation of gene expression|flagellated sperm motility|nuclear receptor coactivator activity|androgen receptor signaling pathway|luteinizing hormone secretion|Leydig cell differentiation|defense response to bacterium|negative regulation of apoptotic process|positive regulation of transcription by RNA polymerase II|androgen receptor binding|regulation of proteasomal protein catabolic process|positive regulation of testosterone secretion TMIE 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.024183352 0.065901706 259236 transmembrane inner ear "GO:0007605,GO:0016021,GO:0042472" sensory perception of sound|integral component of membrane|inner ear morphogenesis TMLHE 391.2131687 341.2557535 441.1705838 1.292785775 0.370483229 0.203376924 1 4.195391007 5.332982841 55217 "trimethyllysine hydroxylase, epsilon" "GO:0005506,GO:0005739,GO:0005759,GO:0045329,GO:0050353,GO:0055114" iron ion binding|mitochondrion|mitochondrial matrix|carnitine biosynthetic process|trimethyllysine dioxygenase activity|oxidation-reduction process hsa00310 Lysine degradation TMOD1 292.5261065 362.0640312 222.9881818 0.615880514 -0.699277611 0.027386137 0.877061895 6.6355398 4.018314282 7111 tropomodulin 1 "GO:0003779,GO:0005523,GO:0005829,GO:0005856,GO:0005865,GO:0005884,GO:0006936,GO:0007015,GO:0008180,GO:0008344,GO:0016020,GO:0030016,GO:0030017,GO:0030049,GO:0030239,GO:0030863,GO:0051015,GO:0051694,GO:0070307" actin binding|tropomyosin binding|cytosol|cytoskeleton|striated muscle thin filament|actin filament|muscle contraction|actin filament organization|COP9 signalosome|adult locomotory behavior|membrane|myofibril|sarcomere|muscle filament sliding|myofibril assembly|cortical cytoskeleton|actin filament binding|pointed-end actin filament capping|lens fiber cell development TMOD2 816.9229273 843.7756588 790.0701958 0.936351016 -0.09487863 0.708841523 1 4.902107132 4.513284006 29767 tropomodulin 2 "GO:0003779,GO:0005515,GO:0005523,GO:0005856,GO:0005865,GO:0006936,GO:0007015,GO:0007270,GO:0007399,GO:0007611,GO:0030016,GO:0030239,GO:0030426,GO:0045202,GO:0045745,GO:0051694" actin binding|protein binding|tropomyosin binding|cytoskeleton|striated muscle thin filament|muscle contraction|actin filament organization|neuron-neuron synaptic transmission|nervous system development|learning or memory|myofibril|myofibril assembly|growth cone|synapse|positive regulation of G protein-coupled receptor signaling pathway|pointed-end actin filament capping TMOD3 1868.178595 1859.219608 1877.137582 1.009637363 0.013837205 0.955876597 1 21.00405025 20.85161228 29766 tropomodulin 3 "GO:0003779,GO:0005523,GO:0005856,GO:0005865,GO:0005912,GO:0006936,GO:0007015,GO:0030016,GO:0030239,GO:0048821,GO:0051694,GO:0098609,GO:0098641,GO:1901992" actin binding|tropomyosin binding|cytoskeleton|striated muscle thin filament|adherens junction|muscle contraction|actin filament organization|myofibril|myofibril assembly|erythrocyte development|pointed-end actin filament capping|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|positive regulation of mitotic cell cycle phase transition TMOD4 7.604959303 10.40413883 4.80577978 0.461910386 -1.11431511 0.425432296 1 0.450324223 0.204528679 29765 tropomodulin 4 "GO:0005515,GO:0005523,GO:0005856,GO:0005865,GO:0006936,GO:0007015,GO:0030016,GO:0030239,GO:0051015,GO:0051694" protein binding|tropomyosin binding|cytoskeleton|striated muscle thin filament|muscle contraction|actin filament organization|myofibril|myofibril assembly|actin filament binding|pointed-end actin filament capping TMPO 5781.867216 5880.419265 5683.315168 0.966481285 -0.049186298 0.839306872 1 43.60527559 41.43846533 7112 thymopoietin "GO:0000785,GO:0003677,GO:0005515,GO:0005521,GO:0005634,GO:0005635,GO:0006355,GO:0045296" "chromatin|DNA binding|protein binding|lamin binding|nucleus|nuclear envelope|regulation of transcription, DNA-templated|cadherin binding" TMPPE 36.70697989 42.65696919 30.75699059 0.721030846 -0.471867115 0.497644221 1 0.528195834 0.374472556 643853 transmembrane protein with metallophosphoesterase domain "GO:0005515,GO:0016021,GO:0016787,GO:0046872" protein binding|integral component of membrane|hydrolase activity|metal ion binding TMPRSS11E 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.078499025 0.047537014 28983 transmembrane serine protease 11E "GO:0004252,GO:0005515,GO:0005576,GO:0005886,GO:0005887,GO:0006508,GO:0008236,GO:0050890" serine-type endopeptidase activity|protein binding|extracellular region|plasma membrane|integral component of plasma membrane|proteolysis|serine-type peptidase activity|cognition TMPRSS15 249.1715216 119.6475965 378.6954467 3.165090296 1.662246659 1.47E-06 0.001008398 1.505628937 4.685708161 5651 transmembrane serine protease 15 "GO:0004252,GO:0005044,GO:0005515,GO:0005903,GO:0006508,GO:0006897,GO:0016020,GO:0016021" serine-type endopeptidase activity|scavenger receptor activity|protein binding|brush border|proteolysis|endocytosis|membrane|integral component of membrane TMPRSS5 7.367185523 4.161655531 10.57271552 2.540507122 1.345116509 0.341208165 1 0.097669264 0.243977351 80975 transmembrane serine protease 5 "GO:0004252,GO:0005044,GO:0005886,GO:0006508,GO:0006897,GO:0008233,GO:0016021,GO:0043025" serine-type endopeptidase activity|scavenger receptor activity|plasma membrane|proteolysis|endocytosis|peptidase activity|integral component of membrane|neuronal cell body TMPRSS7 4.483717655 4.161655531 4.80577978 1.154775965 0.207612985 1 1 0.069996819 0.079478053 344805 transmembrane serine protease 7 "GO:0004252,GO:0005886,GO:0006508,GO:0008236,GO:0016021" serine-type endopeptidase activity|plasma membrane|proteolysis|serine-type peptidase activity|integral component of membrane TMSB10 29048.36696 23677.73914 34418.99478 1.453643635 0.539673631 0.06526598 1 2741.079002 3917.875962 9168 thymosin beta 10 "GO:0003785,GO:0005515,GO:0005737,GO:0005856,GO:0007015,GO:0030334,GO:0042989" actin monomer binding|protein binding|cytoplasm|cytoskeleton|actin filament organization|regulation of cell migration|sequestering of actin monomers TMSB15B 8.848548421 5.202069413 12.49502743 2.401934007 1.264196513 0.321680077 1 0.092203548 0.21776089 286527 thymosin beta 15B "GO:0003674,GO:0003785,GO:0005575,GO:0005737,GO:0005856,GO:0007015,GO:0030334,GO:0030335,GO:0042989" molecular_function|actin monomer binding|cellular_component|cytoplasm|cytoskeleton|actin filament organization|regulation of cell migration|positive regulation of cell migration|sequestering of actin monomers TMSB4X 10928.41564 9262.804797 12594.02649 1.359634233 0.443218591 0.080716737 1 794.757022 1062.49683 7114 thymosin beta 4 X-linked "GO:0002576,GO:0003723,GO:0003785,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0007015,GO:0007253,GO:0019899,GO:0030334,GO:0031093,GO:0032088,GO:0032717,GO:0033209,GO:0042989,GO:0043536,GO:0050727,GO:1901222,GO:1901223,GO:1903026,GO:1905273,GO:2001028,GO:2001171" "platelet degranulation|RNA binding|actin monomer binding|protein binding|extracellular region|nucleus|cytoplasm|cytosol|cytoskeleton|actin filament organization|cytoplasmic sequestering of NF-kappaB|enzyme binding|regulation of cell migration|platelet alpha granule lumen|negative regulation of NF-kappaB transcription factor activity|negative regulation of interleukin-8 production|tumor necrosis factor-mediated signaling pathway|sequestering of actin monomers|positive regulation of blood vessel endothelial cell migration|regulation of inflammatory response|regulation of NIK/NF-kappaB signaling|negative regulation of NIK/NF-kappaB signaling|negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding|positive regulation of proton-transporting ATP synthase activity, rotational mechanism|positive regulation of endothelial cell chemotaxis|positive regulation of ATP biosynthetic process" hsa04810 Regulation of actin cytoskeleton TMTC1 6.445658531 5.202069413 7.689247648 1.478113235 0.563756795 0.78195947 1 0.017239498 0.025055525 83857 transmembrane O-mannosyltransferase targeting cadherins 1 "GO:0000030,GO:0004169,GO:0005783,GO:0006396,GO:0016021,GO:0035269" mannosyltransferase activity|dolichyl-phosphate-mannose-protein mannosyltransferase activity|endoplasmic reticulum|RNA processing|integral component of membrane|protein O-linked mannosylation TMTC2 669.9515832 631.5312268 708.3719396 1.121673655 0.165652993 0.523234852 1 3.256077757 3.591141071 160335 transmembrane O-mannosyltransferase targeting cadherins 2 "GO:0000030,GO:0004169,GO:0005515,GO:0005783,GO:0005789,GO:0016021,GO:0035269,GO:0055074" mannosyltransferase activity|dolichyl-phosphate-mannose-protein mannosyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|protein O-linked mannosylation|calcium ion homeostasis TMTC3 622.2755981 578.4701187 666.0810775 1.151452868 0.20345536 0.437909245 1 4.29253157 4.859939272 160418 transmembrane O-mannosyltransferase targeting cadherins 3 "GO:0000030,GO:0004169,GO:0005515,GO:0005783,GO:0016021,GO:0034976,GO:0035269,GO:1901800" mannosyltransferase activity|dolichyl-phosphate-mannose-protein mannosyltransferase activity|protein binding|endoplasmic reticulum|integral component of membrane|response to endoplasmic reticulum stress|protein O-linked mannosylation|positive regulation of proteasomal protein catabolic process TMTC4 532.0659468 531.651494 532.4803996 1.001559115 0.002247575 1 1 5.125228162 5.047321512 84899 transmembrane O-mannosyltransferase targeting cadherins 4 "GO:0000030,GO:0004169,GO:0005783,GO:0007605,GO:0016021,GO:0030968,GO:0032470,GO:0035269,GO:0051117,GO:1905584" mannosyltransferase activity|dolichyl-phosphate-mannose-protein mannosyltransferase activity|endoplasmic reticulum|sensory perception of sound|integral component of membrane|endoplasmic reticulum unfolded protein response|positive regulation of endoplasmic reticulum calcium ion concentration|protein O-linked mannosylation|ATPase binding|outer hair cell apoptotic process TMUB1 733.2488677 678.3498515 788.1478839 1.16186048 0.216436835 0.396385854 1 23.34125391 26.66547604 83590 transmembrane and ubiquitin like domain containing 1 "GO:0005515,GO:0005730,GO:0005815,GO:0016021,GO:0030433,GO:0045211,GO:0055037" protein binding|nucleolus|microtubule organizing center|integral component of membrane|ubiquitin-dependent ERAD pathway|postsynaptic membrane|recycling endosome TMUB2 627.2392794 683.5519209 570.9266379 0.835235218 -0.259745549 0.320074426 1 13.30897837 10.93011411 79089 transmembrane and ubiquitin like domain containing 2 "GO:0005515,GO:0016021,GO:0030433" protein binding|integral component of membrane|ubiquitin-dependent ERAD pathway TMX1 1403.804332 1401.4375 1406.171164 1.00337772 0.004864809 0.987175601 1 18.58189904 18.3326703 81542 thioredoxin related transmembrane protein 1 "GO:0005515,GO:0005789,GO:0015036,GO:0016021,GO:0034976,GO:0055114" protein binding|endoplasmic reticulum membrane|disulfide oxidoreductase activity|integral component of membrane|response to endoplasmic reticulum stress|oxidation-reduction process TMX2 1527.074484 1496.115163 1558.033805 1.04138628 0.058505305 0.80850462 1 43.7986377 44.84805705 51075 thioredoxin related transmembrane protein 2 "GO:0005515,GO:0005739,GO:0005789,GO:0007420,GO:0015036,GO:0016021,GO:0031966,GO:0042802,GO:0043227,GO:0044233,GO:0055114" protein binding|mitochondrion|endoplasmic reticulum membrane|brain development|disulfide oxidoreductase activity|integral component of membrane|mitochondrial membrane|identical protein binding|membrane-bounded organelle|mitochondria-associated endoplasmic reticulum membrane|oxidation-reduction process TMX3 2242.19721 1837.370917 2647.023503 1.440658214 0.526728107 0.026067049 0.866576205 13.14967264 18.62717864 54495 thioredoxin related transmembrane protein 3 "GO:0002576,GO:0003756,GO:0005515,GO:0005789,GO:0005886,GO:0009986,GO:0016021,GO:0016972,GO:0018171,GO:0018215,GO:0031092" platelet degranulation|protein disulfide isomerase activity|protein binding|endoplasmic reticulum membrane|plasma membrane|cell surface|integral component of membrane|thiol oxidase activity|peptidyl-cysteine oxidation|protein phosphopantetheinylation|platelet alpha granule membrane TMX4 1537.805101 1601.196965 1474.413236 0.920819405 -0.119009859 0.618982838 1 14.00179242 12.67737323 56255 thioredoxin related transmembrane protein 4 "GO:0005637,GO:0016021,GO:0055114" nuclear inner membrane|integral component of membrane|oxidation-reduction process TNC 1577.792568 2348.214133 807.371003 0.343823415 -1.540260295 2.50E-10 8.54E-07 13.69167185 4.628743448 3371 tenascin C "GO:0001649,GO:0005201,GO:0005515,GO:0005576,GO:0005604,GO:0005614,GO:0005615,GO:0005788,GO:0005925,GO:0007155,GO:0007162,GO:0007528,GO:0008284,GO:0009611,GO:0009612,GO:0010628,GO:0014012,GO:0016020,GO:0030198,GO:0042060,GO:0042475,GO:0043687,GO:0044267,GO:0045471,GO:0045545,GO:0060447,GO:0060739,GO:0060740,GO:0062023,GO:0071300,GO:0071305,GO:0071774,GO:0071799,GO:0098966" osteoblast differentiation|extracellular matrix structural constituent|protein binding|extracellular region|basement membrane|interstitial matrix|extracellular space|endoplasmic reticulum lumen|focal adhesion|cell adhesion|negative regulation of cell adhesion|neuromuscular junction development|positive regulation of cell population proliferation|response to wounding|response to mechanical stimulus|positive regulation of gene expression|peripheral nervous system axon regeneration|membrane|extracellular matrix organization|wound healing|odontogenesis of dentin-containing tooth|post-translational protein modification|cellular protein metabolic process|response to ethanol|syndecan binding|bud outgrowth involved in lung branching|mesenchymal-epithelial cell signaling involved in prostate gland development|prostate gland epithelium morphogenesis|collagen-containing extracellular matrix|cellular response to retinoic acid|cellular response to vitamin D|response to fibroblast growth factor|cellular response to prostaglandin D stimulus|perisynaptic extracellular matrix "hsa04151,hsa04510,hsa04512,hsa05165,hsa05206" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Human papillomavirus infection|MicroRNAs in cancer TNF 822.3967547 974.867808 669.9257013 0.687196455 -0.541205502 0.030941872 0.895820653 31.00530583 20.95019686 7124 tumor necrosis factor "GO:0000122,GO:0000165,GO:0000185,GO:0000187,GO:0000976,GO:0001774,GO:0001819,GO:0001891,GO:0001934,GO:0001937,GO:0002020,GO:0002439,GO:0002637,GO:0002719,GO:0002876,GO:0002925,GO:0005125,GO:0005164,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0005887,GO:0006006,GO:0006357,GO:0006919,GO:0006954,GO:0006959,GO:0007249,GO:0007254,GO:0008625,GO:0008630,GO:0009615,GO:0009651,GO:0009897,GO:0009986,GO:0010573,GO:0010628,GO:0010629,GO:0010693,GO:0010803,GO:0010888,GO:0014068,GO:0019221,GO:0030198,GO:0030316,GO:0030730,GO:0030866,GO:0031334,GO:0031622,GO:0031663,GO:0032715,GO:0032722,GO:0032724,GO:0032729,GO:0032731,GO:0032755,GO:0032757,GO:0033138,GO:0033209,GO:0034116,GO:0035509,GO:0042531,GO:0042802,GO:0043065,GO:0043068,GO:0043122,GO:0043123,GO:0043154,GO:0043242,GO:0043243,GO:0043280,GO:0043406,GO:0043491,GO:0043507,GO:0043525,GO:0043537,GO:0045071,GO:0045121,GO:0045429,GO:0045598,GO:0045599,GO:0045662,GO:0045668,GO:0045672,GO:0045732,GO:0045785,GO:0045860,GO:0045892,GO:0045893,GO:0045930,GO:0045944,GO:0045994,GO:0046325,GO:0046330,GO:0046427,GO:0048143,GO:0048566,GO:0048661,GO:0050729,GO:0050766,GO:0050768,GO:0050796,GO:0050806,GO:0050807,GO:0050830,GO:0050890,GO:0050901,GO:0050995,GO:0051000,GO:0051044,GO:0051091,GO:0051092,GO:0051173,GO:0051222,GO:0051384,GO:0051798,GO:0051897,GO:0051966,GO:0055037,GO:0060252,GO:0060557,GO:0060559,GO:0060664,GO:0060693,GO:0061044,GO:0061048,GO:0070374,GO:0070886,GO:0071230,GO:0071316,GO:0071407,GO:0071550,GO:0071677,GO:0071803,GO:0072577,GO:0072659,GO:0097191,GO:0097527,GO:0150078,GO:0150129,GO:1900017,GO:1900222,GO:1901224,GO:1901647,GO:1901671,GO:1902004,GO:1902895,GO:1903078,GO:1903140,GO:1903347,GO:1903721,GO:1903799,GO:1904707,GO:1904996,GO:1904999,GO:2000010,GO:2000272,GO:2000304,GO:2000334,GO:2000343,GO:2000351,GO:2001234,GO:2001238,GO:2001240" "negative regulation of transcription by RNA polymerase II|MAPK cascade|activation of MAPKKK activity|activation of MAPK activity|transcription regulatory region sequence-specific DNA binding|microglial cell activation|positive regulation of cytokine production|phagocytic cup|positive regulation of protein phosphorylation|negative regulation of endothelial cell proliferation|protease binding|chronic inflammatory response to antigenic stimulus|regulation of immunoglobulin production|negative regulation of cytokine production involved in immune response|positive regulation of chronic inflammatory response to antigenic stimulus|positive regulation of humoral immune response mediated by circulating immunoglobulin|cytokine activity|tumor necrosis factor receptor binding|protein binding|extracellular region|extracellular space|plasma membrane|integral component of plasma membrane|glucose metabolic process|regulation of transcription by RNA polymerase II|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|humoral immune response|I-kappaB kinase/NF-kappaB signaling|JNK cascade|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|response to virus|response to salt stress|external side of plasma membrane|cell surface|vascular endothelial growth factor production|positive regulation of gene expression|negative regulation of gene expression|negative regulation of alkaline phosphatase activity|regulation of tumor necrosis factor-mediated signaling pathway|negative regulation of lipid storage|positive regulation of phosphatidylinositol 3-kinase signaling|cytokine-mediated signaling pathway|extracellular matrix organization|osteoclast differentiation|sequestering of triglyceride|cortical actin cytoskeleton organization|positive regulation of protein-containing complex assembly|positive regulation of fever generation|lipopolysaccharide-mediated signaling pathway|negative regulation of interleukin-6 production|positive regulation of chemokine production|positive regulation of fractalkine production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of peptidyl-serine phosphorylation|tumor necrosis factor-mediated signaling pathway|positive regulation of heterotypic cell-cell adhesion|negative regulation of myosin-light-chain-phosphatase activity|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|positive regulation of apoptotic process|positive regulation of programmed cell death|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of protein-containing complex disassembly|positive regulation of protein-containing complex disassembly|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of MAP kinase activity|protein kinase B signaling|positive regulation of JUN kinase activity|positive regulation of neuron apoptotic process|negative regulation of blood vessel endothelial cell migration|negative regulation of viral genome replication|membrane raft|positive regulation of nitric oxide biosynthetic process|regulation of fat cell differentiation|negative regulation of fat cell differentiation|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|positive regulation of osteoclast differentiation|positive regulation of protein catabolic process|positive regulation of cell adhesion|positive regulation of protein kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|positive regulation of translational initiation by iron|negative regulation of glucose import|positive regulation of JNK cascade|positive regulation of receptor signaling pathway via JAK-STAT|astrocyte activation|embryonic digestive tract development|positive regulation of smooth muscle cell proliferation|positive regulation of inflammatory response|positive regulation of phagocytosis|negative regulation of neurogenesis|regulation of insulin secretion|positive regulation of synaptic transmission|regulation of synapse organization|defense response to Gram-positive bacterium|cognition|leukocyte tethering or rolling|negative regulation of lipid catabolic process|positive regulation of nitric-oxide synthase activity|positive regulation of membrane protein ectodomain proteolysis|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitrogen compound metabolic process|positive regulation of protein transport|response to glucocorticoid|positive regulation of hair follicle development|positive regulation of protein kinase B signaling|regulation of synaptic transmission, glutamatergic|recycling endosome|positive regulation of glial cell proliferation|positive regulation of vitamin D biosynthetic process|positive regulation of calcidiol 1-monooxygenase activity|epithelial cell proliferation involved in salivary gland morphogenesis|regulation of branching involved in salivary gland morphogenesis|negative regulation of vascular wound healing|negative regulation of branching involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of calcineurin-NFAT signaling cascade|cellular response to amino acid stimulus|cellular response to nicotine|cellular response to organic cyclic compound|death-inducing signaling complex assembly|positive regulation of mononuclear cell migration|positive regulation of podosome assembly|endothelial cell apoptotic process|protein localization to plasma membrane|extrinsic apoptotic signaling pathway|necroptotic signaling pathway|positive regulation of neuroinflammatory response|positive regulation of interleukin-33 production|positive regulation of cytokine production involved in inflammatory response|negative regulation of amyloid-beta clearance|positive regulation of NIK/NF-kappaB signaling|positive regulation of synoviocyte proliferation|positive regulation of superoxide dismutase activity|positive regulation of amyloid-beta formation|positive regulation of pri-miRNA transcription by RNA polymerase II|positive regulation of protein localization to plasma membrane|regulation of establishment of endothelial barrier|negative regulation of bicellular tight junction assembly|positive regulation of I-kappaB phosphorylation|negative regulation of production of miRNAs involved in gene silencing by miRNA|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of leukocyte adhesion to vascular endothelial cell|positive regulation of leukocyte adhesion to arterial endothelial cell|positive regulation of protein localization to cell surface|negative regulation of signaling receptor activity|positive regulation of ceramide biosynthetic process|positive regulation of blood microparticle formation|positive regulation of chemokine (C-X-C motif) ligand 2 production|regulation of endothelial cell apoptotic process|negative regulation of apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand" "hsa01523,hsa04010,hsa04060,hsa04061,hsa04064,hsa04071,hsa04150,hsa04210,hsa04217,hsa04350,hsa04380,hsa04612,hsa04620,hsa04621,hsa04622,hsa04625,hsa04640,hsa04650,hsa04657,hsa04660,hsa04664,hsa04668,hsa04920,hsa04930,hsa04931,hsa04932,hsa04933,hsa04940,hsa05010,hsa05014,hsa05020,hsa05022,hsa05130,hsa05131,hsa05132,hsa05133,hsa05134,hsa05135,hsa05140,hsa05142,hsa05143,hsa05144,hsa05145,hsa05146,hsa05152,hsa05160,hsa05161,hsa05163,hsa05164,hsa05165,hsa05166,hsa05168,hsa05169,hsa05170,hsa05171,hsa05205,hsa05310,hsa05321,hsa05322,hsa05323,hsa05330,hsa05332,hsa05410,hsa05414,hsa05418" Antifolate resistance|MAPK signaling pathway|Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|NF-kappa B signaling pathway|Sphingolipid signaling pathway|mTOR signaling pathway|Apoptosis|Necroptosis|TGF-beta signaling pathway|Osteoclast differentiation|Antigen processing and presentation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|Hematopoietic cell lineage|Natural killer cell mediated cytotoxicity|IL-17 signaling pathway|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Adipocytokine signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease|AGE-RAGE signaling pathway in diabetic complications|Type I diabetes mellitus|Alzheimer disease|Amyotrophic lateral sclerosis|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Yersinia infection|Leishmaniasis|Chagas disease|African trypanosomiasis|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Proteoglycans in cancer|Asthma|Inflammatory bowel disease|Systemic lupus erythematosus|Rheumatoid arthritis|Allograft rejection|Graft-versus-host disease|Hypertrophic cardiomyopathy|Dilated cardiomyopathy|Fluid shear stress and atherosclerosis TNFAIP1 2204.754329 2229.606951 2179.901708 0.977706724 -0.03252632 0.892424248 1 32.51093582 31.25426222 7126 TNF alpha induced protein 1 "GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005768,GO:0006915,GO:0006955,GO:0016477,GO:0016567,GO:0031267,GO:0031463,GO:0035024,GO:0042802,GO:0043149,GO:0043161,GO:0045740,GO:0051260" ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|endosome|apoptotic process|immune response|cell migration|protein ubiquitination|small GTPase binding|Cul3-RING ubiquitin ligase complex|negative regulation of Rho protein signal transduction|identical protein binding|stress fiber assembly|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of DNA replication|protein homooligomerization TNFAIP2 3750.358234 4552.85115 2947.865317 0.647476761 -0.627099681 0.008512314 0.570617113 55.99845543 35.65097507 7127 TNF alpha induced protein 2 "GO:0000145,GO:0000149,GO:0001525,GO:0005515,GO:0005615,GO:0006887,GO:0030154,GO:0051601" exocyst|SNARE binding|angiogenesis|protein binding|extracellular space|exocytosis|cell differentiation|exocyst localization TNFAIP3 6719.727947 7438.959261 6000.496633 0.8066312 -0.310018886 0.203600505 1 66.7794085 52.9649739 7128 TNF alpha induced protein 3 "GO:0001922,GO:0002020,GO:0002237,GO:0002634,GO:0002677,GO:0003677,GO:0004842,GO:0004843,GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005829,GO:0006915,GO:0006954,GO:0007010,GO:0008022,GO:0008234,GO:0008270,GO:0010803,GO:0016477,GO:0016579,GO:0018215,GO:0019900,GO:0030177,GO:0031397,GO:0032088,GO:0032480,GO:0032495,GO:0032691,GO:0032703,GO:0032715,GO:0032720,GO:0034136,GO:0034140,GO:0034144,GO:0034148,GO:0035523,GO:0035871,GO:0042802,GO:0043124,GO:0043130,GO:0043621,GO:0045732,GO:0045736,GO:0045779,GO:0045824,GO:0048662,GO:0050691,GO:0050728,GO:0050869,GO:0061043,GO:0061578,GO:0070062,GO:0070301,GO:0070423,GO:0070429,GO:0070433,GO:0070530,GO:0070536,GO:0070936,GO:0071108,GO:0071222,GO:0071947,GO:0072573,GO:0072666,GO:0090291,GO:1902042,GO:1903364,GO:1990168,GO:2000347,GO:2000349,GO:2000352" B-1 B cell homeostasis|protease binding|response to molecule of bacterial origin|regulation of germinal center formation|negative regulation of chronic inflammatory response|DNA binding|ubiquitin-protein transferase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytoplasm|lysosome|cytosol|apoptotic process|inflammatory response|cytoskeleton organization|protein C-terminus binding|cysteine-type peptidase activity|zinc ion binding|regulation of tumor necrosis factor-mediated signaling pathway|cell migration|protein deubiquitination|protein phosphopantetheinylation|kinase binding|positive regulation of Wnt signaling pathway|negative regulation of protein ubiquitination|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|response to muramyl dipeptide|negative regulation of interleukin-1 beta production|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of toll-like receptor 5 signaling pathway|protein K29-linked deubiquitination|protein K11-linked deubiquitination|identical protein binding|negative regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|protein self-association|positive regulation of protein catabolic process|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of bone resorption|negative regulation of innate immune response|negative regulation of smooth muscle cell proliferation|regulation of defense response to virus by host|negative regulation of inflammatory response|negative regulation of B cell activation|regulation of vascular wound healing|Lys63-specific deubiquitinase activity|extracellular exosome|cellular response to hydrogen peroxide|nucleotide-binding oligomerization domain containing signaling pathway|negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway|negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|K63-linked polyubiquitin modification-dependent protein binding|protein K63-linked deubiquitination|protein K48-linked ubiquitination|protein K48-linked deubiquitination|cellular response to lipopolysaccharide|protein deubiquitination involved in ubiquitin-dependent protein catabolic process|tolerance induction to lipopolysaccharide|establishment of protein localization to vacuole|negative regulation of osteoclast proliferation|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of cellular protein catabolic process|protein K33-linked deubiquitination|positive regulation of hepatocyte proliferation|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptotic process "hsa04064,hsa04217,hsa04621,hsa04657,hsa04668,hsa05162,hsa05169" NF-kappa B signaling pathway|Necroptosis|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Measles|Epstein-Barr virus infection TNFAIP6 62.00903603 63.46524684 60.55282523 0.954109977 -0.067772524 0.933366615 1 2.381873122 2.234540548 7130 TNF alpha induced protein 6 "GO:0005515,GO:0005540,GO:0005576,GO:0005615,GO:0006954,GO:0007155,GO:0007165,GO:0007267,GO:0030335,GO:0030728,GO:0043312,GO:0050728,GO:1904724,GO:1904813" protein binding|hyaluronic acid binding|extracellular region|extracellular space|inflammatory response|cell adhesion|signal transduction|cell-cell signaling|positive regulation of cell migration|ovulation|neutrophil degranulation|negative regulation of inflammatory response|tertiary granule lumen|ficolin-1-rich granule lumen TNFAIP8 483.2457523 435.9334168 530.5580877 1.21706221 0.283402913 0.304718709 1 7.073568028 8.464912844 25816 TNF alpha induced protein 8 "GO:0005515,GO:0005654,GO:0005737,GO:0006915,GO:0043027,GO:0043065,GO:0043066,GO:0043154" protein binding|nucleoplasm|cytoplasm|apoptotic process|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process TNFAIP8L1 850.3897787 877.0689031 823.7106543 0.939162991 -0.090552537 0.720404415 1 9.831454605 9.0788309 126282 TNF alpha induced protein 8 like 1 "GO:0005515,GO:0005737,GO:0032007,GO:0042802,GO:0042981" protein binding|cytoplasm|negative regulation of TOR signaling|identical protein binding|regulation of apoptotic process TNFAIP8L3 57.48568942 58.26317743 56.7082014 0.97331117 -0.039026983 0.979599862 1 1.254801734 1.200875532 388121 TNF alpha induced protein 8 like 3 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006644,GO:0008526,GO:0015914,GO:0019216,GO:0035091,GO:0042981,GO:0043552,GO:0048017,GO:0051897,GO:0070374,GO:0120009" protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|phospholipid metabolic process|phosphatidylinositol transfer activity|phospholipid transport|regulation of lipid metabolic process|phosphatidylinositol binding|regulation of apoptotic process|positive regulation of phosphatidylinositol 3-kinase activity|inositol lipid-mediated signaling|positive regulation of protein kinase B signaling|positive regulation of ERK1 and ERK2 cascade|intermembrane lipid transfer TNFRSF10A 310.9962753 342.2961674 279.6963832 0.817118069 -0.291383541 0.350819683 1 6.790972989 5.456171285 8797 TNF receptor superfamily member 10a "GO:0002020,GO:0005035,GO:0005515,GO:0005794,GO:0005829,GO:0005886,GO:0006915,GO:0006919,GO:0007165,GO:0007166,GO:0007250,GO:0008134,GO:0008625,GO:0009986,GO:0016021,GO:0036462,GO:0038023,GO:0042802,GO:0042981,GO:0043065,GO:0045121,GO:0045569,GO:0050900,GO:0071260,GO:0097191,GO:1902041,GO:1902042" protease binding|death receptor activity|protein binding|Golgi apparatus|cytosol|plasma membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|cell surface receptor signaling pathway|activation of NF-kappaB-inducing kinase activity|transcription factor binding|extrinsic apoptotic signaling pathway via death domain receptors|cell surface|integral component of membrane|TRAIL-activated apoptotic signaling pathway|signaling receptor activity|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|membrane raft|TRAIL binding|leukocyte migration|cellular response to mechanical stimulus|extrinsic apoptotic signaling pathway|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors "hsa04060,hsa04061,hsa04115,hsa04210,hsa04217,hsa04650,hsa05130,hsa05132,hsa05164" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|p53 signaling pathway|Apoptosis|Necroptosis|Natural killer cell mediated cytotoxicity|Pathogenic Escherichia coli infection|Salmonella infection|Influenza A TNFRSF10B 3856.503643 4210.554983 3502.452304 0.831826759 -0.265645 0.26420102 1 56.20549794 45.97088506 8795 TNF receptor superfamily member 10b "GO:0005515,GO:0005886,GO:0006915,GO:0006919,GO:0007166,GO:0007250,GO:0008625,GO:0009986,GO:0016021,GO:0034976,GO:0036462,GO:0038023,GO:0042981,GO:0043065,GO:0043123,GO:0045569,GO:0050900,GO:0070059,GO:0071260,GO:1902041,GO:1902042" protein binding|plasma membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell surface receptor signaling pathway|activation of NF-kappaB-inducing kinase activity|extrinsic apoptotic signaling pathway via death domain receptors|cell surface|integral component of membrane|response to endoplasmic reticulum stress|TRAIL-activated apoptotic signaling pathway|signaling receptor activity|regulation of apoptotic process|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|TRAIL binding|leukocyte migration|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to mechanical stimulus|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors "hsa04060,hsa04061,hsa04115,hsa04210,hsa04217,hsa04650,hsa05130,hsa05132,hsa05164" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|p53 signaling pathway|Apoptosis|Necroptosis|Natural killer cell mediated cytotoxicity|Pathogenic Escherichia coli infection|Salmonella infection|Influenza A TNFRSF10C 38.99098289 39.53572754 38.44623824 0.972442918 -0.040314528 0.995654494 1 1.512508326 1.446215695 8794 TNF receptor superfamily member 10c "GO:0004888,GO:0005515,GO:0005886,GO:0009986,GO:0031225,GO:0036462,GO:0042981,GO:0043065,GO:0045569" transmembrane signaling receptor activity|protein binding|plasma membrane|cell surface|anchored component of membrane|TRAIL-activated apoptotic signaling pathway|regulation of apoptotic process|positive regulation of apoptotic process|TRAIL binding "hsa04060,hsa04061" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor TNFRSF10D 373.5506704 344.3769952 402.7243456 1.169428711 0.225803917 0.446632444 1 5.199085514 5.978219977 8793 TNF receptor superfamily member 10d "GO:0004888,GO:0005515,GO:0005886,GO:0006915,GO:0007165,GO:0007166,GO:0009986,GO:0016021,GO:0042981,GO:0043066,GO:0045569,GO:0050900" transmembrane signaling receptor activity|protein binding|plasma membrane|apoptotic process|signal transduction|cell surface receptor signaling pathway|cell surface|integral component of membrane|regulation of apoptotic process|negative regulation of apoptotic process|TRAIL binding|leukocyte migration "hsa04060,hsa04061" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor TNFRSF11A 242.8636429 269.4671956 216.2600901 0.802547002 -0.317342206 0.35044752 1 2.688534113 2.121569224 8792 TNF receptor superfamily member 11a "GO:0001503,GO:0002250,GO:0002548,GO:0004888,GO:0005031,GO:0005515,GO:0005829,GO:0005886,GO:0007165,GO:0007267,GO:0008284,GO:0009314,GO:0009897,GO:0016021,GO:0019955,GO:0030316,GO:0032496,GO:0033209,GO:0034097,GO:0034612,GO:0038023,GO:0043507,GO:0045780,GO:0046872,GO:0048535,GO:0051091,GO:0051092,GO:0060086,GO:0060749,GO:0070555,GO:0071812,GO:0071847,GO:0071848,GO:0072674" ossification|adaptive immune response|monocyte chemotaxis|transmembrane signaling receptor activity|tumor necrosis factor-activated receptor activity|protein binding|cytosol|plasma membrane|signal transduction|cell-cell signaling|positive regulation of cell population proliferation|response to radiation|external side of plasma membrane|integral component of membrane|cytokine binding|osteoclast differentiation|response to lipopolysaccharide|tumor necrosis factor-mediated signaling pathway|response to cytokine|response to tumor necrosis factor|signaling receptor activity|positive regulation of JUN kinase activity|positive regulation of bone resorption|metal ion binding|lymph node development|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|circadian temperature homeostasis|mammary gland alveolus development|response to interleukin-1|positive regulation of fever generation by positive regulation of prostaglandin secretion|TNFSF11-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|multinuclear osteoclast differentiation "hsa04060,hsa04064,hsa04380,hsa04917,hsa05323" Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Osteoclast differentiation|Prolactin signaling pathway|Rheumatoid arthritis TNFRSF11B 65.71968171 97.79890497 33.64045846 0.343975819 -1.539620945 0.005205555 0.436723714 2.500885391 0.845849081 4982 TNF receptor superfamily member 11b "GO:0001501,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0006915,GO:0007165,GO:0007584,GO:0030198,GO:0031012,GO:0032026,GO:0033209,GO:0038023,GO:0042489,GO:0042493,GO:0043627,GO:0045779,GO:0046685" skeletal system development|cytokine activity|protein binding|extracellular region|extracellular space|plasma membrane|apoptotic process|signal transduction|response to nutrient|extracellular matrix organization|extracellular matrix|response to magnesium ion|tumor necrosis factor-mediated signaling pathway|signaling receptor activity|negative regulation of odontogenesis of dentin-containing tooth|response to drug|response to estrogen|negative regulation of bone resorption|response to arsenic-containing substance "hsa04060,hsa04380" Cytokine-cytokine receptor interaction|Osteoclast differentiation TNFRSF12A 2840.165277 2610.398432 3069.932123 1.176039675 0.233936732 0.322893118 1 142.5917775 164.8874626 51330 TNF receptor superfamily member 12A "GO:0001525,GO:0005515,GO:0005886,GO:0006915,GO:0007155,GO:0016021,GO:0030154,GO:0033209,GO:0043065,GO:0061041,GO:2001238" angiogenesis|protein binding|plasma membrane|apoptotic process|cell adhesion|integral component of membrane|cell differentiation|tumor necrosis factor-mediated signaling pathway|positive regulation of apoptotic process|regulation of wound healing|positive regulation of extrinsic apoptotic signaling pathway hsa04060 Cytokine-cytokine receptor interaction TNFRSF13C 32.22326223 38.49531366 25.95121081 0.674139482 -0.568880973 0.432720919 1 0.52368701 0.347130475 115650 TNF receptor superfamily member 13C "GO:0002250,GO:0005886,GO:0009897,GO:0016021,GO:0030890,GO:0031295,GO:0031296,GO:0033209,GO:0038023,GO:0042102" adaptive immune response|plasma membrane|external side of plasma membrane|integral component of membrane|positive regulation of B cell proliferation|T cell costimulation|B cell costimulation|tumor necrosis factor-mediated signaling pathway|signaling receptor activity|positive regulation of T cell proliferation "hsa04060,hsa04064,hsa04672,hsa05166,hsa05340" Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Intestinal immune network for IgA production|Human T-cell leukemia virus 1 infection|Primary immunodeficiency TNFRSF14 128.5464491 119.6475965 137.4453017 1.148751047 0.200066176 0.65230818 1 2.153582571 2.43253236 8764 TNF receptor superfamily member 14 "GO:0001618,GO:0002250,GO:0002720,GO:0005031,GO:0005515,GO:0005886,GO:0006955,GO:0007166,GO:0009897,GO:0016021,GO:0019955,GO:0031295,GO:0031625,GO:0033209,GO:0045087,GO:0046642,GO:0046718,GO:0050731,GO:0050829,GO:0050830,GO:1905675,GO:2000406" virus receptor activity|adaptive immune response|positive regulation of cytokine production involved in immune response|tumor necrosis factor-activated receptor activity|protein binding|plasma membrane|immune response|cell surface receptor signaling pathway|external side of plasma membrane|integral component of membrane|cytokine binding|T cell costimulation|ubiquitin protein ligase binding|tumor necrosis factor-mediated signaling pathway|innate immune response|negative regulation of alpha-beta T cell proliferation|viral entry into host cell|positive regulation of peptidyl-tyrosine phosphorylation|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|negative regulation of adaptive immune memory response|positive regulation of T cell migration "hsa04060,hsa04061,hsa05168" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Herpes simplex virus 1 infection TNFRSF17 4.042768641 5.202069413 2.883467868 0.554292463 -0.851280704 0.745112452 1 0.311587973 0.169820782 608 TNF receptor superfamily member 17 "GO:0002250,GO:0002260,GO:0005515,GO:0005886,GO:0007165,GO:0007275,GO:0012505,GO:0016021,GO:0033209,GO:0038023" adaptive immune response|lymphocyte homeostasis|protein binding|plasma membrane|signal transduction|multicellular organism development|endomembrane system|integral component of membrane|tumor necrosis factor-mediated signaling pathway|signaling receptor activity "hsa04060,hsa04672" Cytokine-cytokine receptor interaction|Intestinal immune network for IgA production TNFRSF19 106.9305009 94.67766332 119.1833385 1.2588327 0.33208656 0.475039119 1 0.822793174 1.018426929 55504 TNF receptor superfamily member 19 "GO:0001942,GO:0005031,GO:0005515,GO:0005886,GO:0006915,GO:0007254,GO:0016021,GO:0033209,GO:0038023,GO:0043123,GO:0046330" hair follicle development|tumor necrosis factor-activated receptor activity|protein binding|plasma membrane|apoptotic process|JNK cascade|integral component of membrane|tumor necrosis factor-mediated signaling pathway|signaling receptor activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of JNK cascade hsa04060 Cytokine-cytokine receptor interaction TNFRSF1A 2643.281178 2727.9652 2558.597155 0.937914147 -0.092472224 0.696683023 1 63.60266009 58.65560857 7132 TNF receptor superfamily member 1A "GO:0000139,GO:0002947,GO:0003176,GO:0003177,GO:0003332,GO:0005031,GO:0005515,GO:0005576,GO:0005615,GO:0005739,GO:0005886,GO:0005887,GO:0006693,GO:0006954,GO:0007249,GO:0008625,GO:0008630,GO:0009986,GO:0010614,GO:0010803,GO:0016020,GO:0016032,GO:0019221,GO:0033209,GO:0042531,GO:0042742,GO:0043120,GO:0043123,GO:0043235,GO:0045121,GO:0045944,GO:0050728,GO:0050729,GO:0071260,GO:0071550,GO:0072659,GO:1902339,GO:1903140,GO:2000304" Golgi membrane|tumor necrosis factor receptor superfamily complex|aortic valve development|pulmonary valve development|negative regulation of extracellular matrix constituent secretion|tumor necrosis factor-activated receptor activity|protein binding|extracellular region|extracellular space|mitochondrion|plasma membrane|integral component of plasma membrane|prostaglandin metabolic process|inflammatory response|I-kappaB kinase/NF-kappaB signaling|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|cell surface|negative regulation of cardiac muscle hypertrophy|regulation of tumor necrosis factor-mediated signaling pathway|membrane|viral process|cytokine-mediated signaling pathway|tumor necrosis factor-mediated signaling pathway|positive regulation of tyrosine phosphorylation of STAT protein|defense response to bacterium|tumor necrosis factor binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|receptor complex|membrane raft|positive regulation of transcription by RNA polymerase II|negative regulation of inflammatory response|positive regulation of inflammatory response|cellular response to mechanical stimulus|death-inducing signaling complex assembly|protein localization to plasma membrane|positive regulation of apoptotic process involved in morphogenesis|regulation of establishment of endothelial barrier|positive regulation of ceramide biosynthetic process "hsa04010,hsa04060,hsa04061,hsa04064,hsa04071,hsa04150,hsa04210,hsa04215,hsa04217,hsa04380,hsa04668,hsa04920,hsa04931,hsa04932,hsa05010,hsa05014,hsa05022,hsa05130,hsa05131,hsa05132,hsa05142,hsa05145,hsa05152,hsa05160,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05170,hsa05171,hsa05418" MAPK signaling pathway|Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|NF-kappa B signaling pathway|Sphingolipid signaling pathway|mTOR signaling pathway|Apoptosis|Apoptosis - multiple species|Necroptosis|Osteoclast differentiation|TNF signaling pathway|Adipocytokine signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Alzheimer disease|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis C|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Fluid shear stress and atherosclerosis TNFRSF1B 10.25065339 4.161655531 16.33965125 3.92623828 1.973147731 0.097278628 1 0.058431967 0.225578829 7133 TNF receptor superfamily member 1B "GO:0002718,GO:0002724,GO:0002947,GO:0003176,GO:0003177,GO:0003332,GO:0005031,GO:0005515,GO:0005576,GO:0005634,GO:0005886,GO:0006954,GO:0007568,GO:0008630,GO:0010614,GO:0016020,GO:0016021,GO:0019221,GO:0031625,GO:0031641,GO:0031643,GO:0033209,GO:0035579,GO:0042129,GO:0043025,GO:0043120,GO:0043196,GO:0043312,GO:0045121,GO:0048471,GO:0048714,GO:0050779,GO:0051044,GO:0060548,GO:0071222,GO:0071363,GO:0097191,GO:0150077,GO:0150079,GO:0150098,GO:1901215,GO:1902339,GO:2001141" regulation of cytokine production involved in immune response|regulation of T cell cytokine production|tumor necrosis factor receptor superfamily complex|aortic valve development|pulmonary valve development|negative regulation of extracellular matrix constituent secretion|tumor necrosis factor-activated receptor activity|protein binding|extracellular region|nucleus|plasma membrane|inflammatory response|aging|intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of cardiac muscle hypertrophy|membrane|integral component of membrane|cytokine-mediated signaling pathway|ubiquitin protein ligase binding|regulation of myelination|positive regulation of myelination|tumor necrosis factor-mediated signaling pathway|specific granule membrane|regulation of T cell proliferation|neuronal cell body|tumor necrosis factor binding|varicosity|neutrophil degranulation|membrane raft|perinuclear region of cytoplasm|positive regulation of oligodendrocyte differentiation|RNA destabilization|positive regulation of membrane protein ectodomain proteolysis|negative regulation of cell death|cellular response to lipopolysaccharide|cellular response to growth factor stimulus|extrinsic apoptotic signaling pathway|regulation of neuroinflammatory response|negative regulation of neuroinflammatory response|glial cell-neuron signaling|negative regulation of neuron death|positive regulation of apoptotic process involved in morphogenesis|regulation of RNA biosynthetic process "hsa04060,hsa04061,hsa04668,hsa04920,hsa05014,hsa05022,hsa05170" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|TNF signaling pathway|Adipocytokine signaling pathway|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Human immunodeficiency virus 1 infection TNFRSF21 349.4865585 431.7717613 267.2013558 0.618848613 -0.692341563 0.021195549 0.821508434 6.172747211 3.756073591 27242 TNF receptor superfamily member 21 "GO:0001783,GO:0002250,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0006915,GO:0006959,GO:0007413,GO:0016032,GO:0019216,GO:0030424,GO:0030889,GO:0031226,GO:0031642,GO:0032693,GO:0032696,GO:0032714,GO:0042130,GO:0042552,GO:0048713,GO:0050852,GO:0051402,GO:0071356,GO:0097252" B cell apoptotic process|adaptive immune response|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|apoptotic process|humoral immune response|axonal fasciculation|viral process|regulation of lipid metabolic process|axon|negative regulation of B cell proliferation|intrinsic component of plasma membrane|negative regulation of myelination|negative regulation of interleukin-10 production|negative regulation of interleukin-13 production|negative regulation of interleukin-5 production|negative regulation of T cell proliferation|myelination|regulation of oligodendrocyte differentiation|T cell receptor signaling pathway|neuron apoptotic process|cellular response to tumor necrosis factor|oligodendrocyte apoptotic process hsa04060 Cytokine-cytokine receptor interaction TNFRSF25 362.9137882 304.8412676 420.9863087 1.3810017 0.465715095 0.11718426 1 7.201778742 9.779241387 8718 TNF receptor superfamily member 25 "GO:0005031,GO:0005576,GO:0005829,GO:0005886,GO:0005887,GO:0006915,GO:0007165,GO:0007166,GO:0033209,GO:0038023,GO:0042981,GO:0097190" tumor necrosis factor-activated receptor activity|extracellular region|cytosol|plasma membrane|integral component of plasma membrane|apoptotic process|signal transduction|cell surface receptor signaling pathway|tumor necrosis factor-mediated signaling pathway|signaling receptor activity|regulation of apoptotic process|apoptotic signaling pathway hsa04060 Cytokine-cytokine receptor interaction TNFRSF6B 4277.832021 3361.577255 5194.086786 1.545133844 0.627731814 0.008715767 0.573019799 157.3694735 239.0879981 8771 TNF receptor superfamily member 6b "GO:0005515,GO:0005576,GO:0005615,GO:0006915,GO:0033209,GO:0038023,GO:0043066" protein binding|extracellular region|extracellular space|apoptotic process|tumor necrosis factor-mediated signaling pathway|signaling receptor activity|negative regulation of apoptotic process hsa04060 Cytokine-cytokine receptor interaction TNFRSF9 317.8225178 496.277422 139.3676136 0.280826021 -1.832251476 9.95E-09 1.24E-05 3.855227641 1.064531586 3604 TNF receptor superfamily member 9 "GO:0005515,GO:0005886,GO:0005887,GO:0006915,GO:0008285,GO:0009897,GO:0019955,GO:0033209,GO:0038023,GO:0042127" protein binding|plasma membrane|integral component of plasma membrane|apoptotic process|negative regulation of cell population proliferation|external side of plasma membrane|cytokine binding|tumor necrosis factor-mediated signaling pathway|signaling receptor activity|regulation of cell population proliferation hsa04060 Cytokine-cytokine receptor interaction TNFSF10 28.02197774 29.13158871 26.91236677 0.923820772 -0.11431511 0.927935804 1 0.520488566 0.472791974 8743 TNF superfamily member 10 "GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005576,GO:0005887,GO:0006915,GO:0006919,GO:0006955,GO:0007165,GO:0007166,GO:0007267,GO:0008270,GO:0008584,GO:0032868,GO:0042802,GO:0043065,GO:0043123,GO:0043280,GO:0045569,GO:0070062,GO:0090200,GO:1902041,GO:1902042,GO:2001238" signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|extracellular region|integral component of plasma membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|immune response|signal transduction|cell surface receptor signaling pathway|cell-cell signaling|zinc ion binding|male gonad development|response to insulin|identical protein binding|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|TRAIL binding|extracellular exosome|positive regulation of release of cytochrome c from mitochondria|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of extrinsic apoptotic signaling pathway "hsa04060,hsa04061,hsa04068,hsa04210,hsa04217,hsa04650,hsa05130,hsa05132,hsa05164" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|FoxO signaling pathway|Apoptosis|Necroptosis|Natural killer cell mediated cytotoxicity|Pathogenic Escherichia coli infection|Salmonella infection|Influenza A TNFSF12 187.7959346 173.7491184 201.8427508 1.161690791 0.216226115 0.568728463 1 6.733965949 7.691882495 8742 TNF superfamily member 12 "GO:0001525,GO:0001938,GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0005887,GO:0006915,GO:0006955,GO:0007165,GO:0030154,GO:0033209,GO:0043542,GO:0045732,GO:0045766,GO:0048471,GO:0097191,GO:2001238" angiogenesis|positive regulation of endothelial cell proliferation|signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|extracellular region|extracellular space|plasma membrane|integral component of plasma membrane|apoptotic process|immune response|signal transduction|cell differentiation|tumor necrosis factor-mediated signaling pathway|endothelial cell migration|positive regulation of protein catabolic process|positive regulation of angiogenesis|perinuclear region of cytoplasm|extrinsic apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway hsa04060 Cytokine-cytokine receptor interaction TNFSF13 3.522561699 4.161655531 2.883467868 0.692865579 -0.529352609 0.940314863 1 0.116587878 0.079427988 8741 TNF superfamily member 13 "GO:0005102,GO:0005125,GO:0005164,GO:0005576,GO:0005615,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006955,GO:0007165,GO:0008284,GO:0033209,GO:0043488,GO:0048298,GO:0070062" signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|extracellular region|extracellular space|nucleoplasm|cytoplasm|cytosol|plasma membrane|immune response|signal transduction|positive regulation of cell population proliferation|tumor necrosis factor-mediated signaling pathway|regulation of mRNA stability|positive regulation of isotype switching to IgA isotypes|extracellular exosome "hsa04060,hsa04672,hsa05323" Cytokine-cytokine receptor interaction|Intestinal immune network for IgA production|Rheumatoid arthritis TNFSF13B 19.61437834 22.88910542 16.33965125 0.713861505 -0.486283887 0.601783098 1 0.458367538 0.321735508 10673 TNF superfamily member 13b "GO:0001782,GO:0002636,GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005886,GO:0005925,GO:0006955,GO:0007165,GO:0016021,GO:0030890,GO:0031295,GO:0031296,GO:0033209,GO:0042102,GO:0043231,GO:0048471" B cell homeostasis|positive regulation of germinal center formation|signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|extracellular region|extracellular space|cytoplasm|plasma membrane|focal adhesion|immune response|signal transduction|integral component of membrane|positive regulation of B cell proliferation|T cell costimulation|B cell costimulation|tumor necrosis factor-mediated signaling pathway|positive regulation of T cell proliferation|intracellular membrane-bounded organelle|perinuclear region of cytoplasm "hsa04060,hsa04064,hsa04672,hsa05323" Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Intestinal immune network for IgA production|Rheumatoid arthritis TNFSF14 4.602604545 7.282897178 1.922311912 0.263948792 -1.921670032 0.302322524 1 0.071159802 0.018468243 8740 TNF superfamily member 14 "GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005615,GO:0005737,GO:0005886,GO:0006915,GO:0006955,GO:0007165,GO:0016021,GO:0031295,GO:0033209,GO:0042098,GO:0042110,GO:0043027,GO:0043029,GO:0043154,GO:0071260,GO:1901224" signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|extracellular space|cytoplasm|plasma membrane|apoptotic process|immune response|signal transduction|integral component of membrane|T cell costimulation|tumor necrosis factor-mediated signaling pathway|T cell proliferation|T cell activation|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|T cell homeostasis|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to mechanical stimulus|positive regulation of NIK/NF-kappaB signaling "hsa04060,hsa04061,hsa04064,hsa05168" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|NF-kappa B signaling pathway|Herpes simplex virus 1 infection TNFSF15 17.97449958 17.687036 18.26196316 1.032505568 0.046149562 1 1 0.143018879 0.145196769 9966 TNF superfamily member 15 "GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0006915,GO:0006919,GO:0006955,GO:0007165,GO:0007250,GO:0016021,GO:0033209" signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|immune response|signal transduction|activation of NF-kappaB-inducing kinase activity|integral component of membrane|tumor necrosis factor-mediated signaling pathway hsa04060 Cytokine-cytokine receptor interaction TNFSF4 31.53950902 45.77821084 17.30080721 0.377926679 -1.403821727 0.050423653 1 0.188089843 0.069894673 7292 TNF superfamily member 4 "GO:0001819,GO:0002215,GO:0002526,GO:0002639,GO:0002726,GO:0002819,GO:0002830,GO:0002891,GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0007165,GO:0008284,GO:0009615,GO:0009986,GO:0032689,GO:0032700,GO:0032729,GO:0032733,GO:0032735,GO:0032736,GO:0032753,GO:0032755,GO:0032813,GO:0033209,GO:0035709,GO:0035712,GO:0035713,GO:0042102,GO:0043372,GO:0043382,GO:0043433,GO:0045590,GO:0045626,GO:0045630,GO:0045892,GO:0046641,GO:0050727,GO:0050729,GO:0050871,GO:0071222,GO:0071380,GO:0071954,GO:1900281,GO:2000572" "positive regulation of cytokine production|defense response to nematode|acute inflammatory response|positive regulation of immunoglobulin production|positive regulation of T cell cytokine production|regulation of adaptive immune response|positive regulation of type 2 immune response|positive regulation of immunoglobulin mediated immune response|signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|signal transduction|positive regulation of cell population proliferation|response to virus|cell surface|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|tumor necrosis factor receptor superfamily binding|tumor necrosis factor-mediated signaling pathway|memory T cell activation|T-helper 2 cell activation|response to nitrogen dioxide|positive regulation of T cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of memory T cell differentiation|negative regulation of DNA-binding transcription factor activity|negative regulation of regulatory T cell differentiation|negative regulation of T-helper 1 cell differentiation|positive regulation of T-helper 2 cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of alpha-beta T cell proliferation|regulation of inflammatory response|positive regulation of inflammatory response|positive regulation of B cell activation|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|positive regulation of CD4-positive, alpha-beta T cell costimulation|positive regulation of interleukin-4-dependent isotype switching to IgE isotypes" hsa04060 Cytokine-cytokine receptor interaction TNFSF8 4.483717655 4.161655531 4.80577978 1.154775965 0.207612985 1 1 0.047416718 0.053839424 944 TNF superfamily member 8 "GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0006955,GO:0007267,GO:0033209,GO:0042129,GO:0043374,GO:0045944,GO:0050830" "signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|immune response|cell-cell signaling|tumor necrosis factor-mediated signaling pathway|regulation of T cell proliferation|CD8-positive, alpha-beta T cell differentiation|positive regulation of transcription by RNA polymerase II|defense response to Gram-positive bacterium" hsa04060 Cytokine-cytokine receptor interaction TNFSF9 108.6842362 115.485941 101.8825313 0.882207223 -0.180810522 0.704968712 1 3.771892543 3.271908121 8744 TNF superfamily member 9 "GO:0005102,GO:0005125,GO:0005164,GO:0005615,GO:0005886,GO:0006955,GO:0007267,GO:0016021,GO:0032813,GO:0033209,GO:0042104,GO:0042129,GO:0042981,GO:0045585" signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|extracellular space|plasma membrane|immune response|cell-cell signaling|integral component of membrane|tumor necrosis factor receptor superfamily binding|tumor necrosis factor-mediated signaling pathway|positive regulation of activated T cell proliferation|regulation of T cell proliferation|regulation of apoptotic process|positive regulation of cytotoxic T cell differentiation hsa04060 Cytokine-cytokine receptor interaction TNIK 720.7884388 691.875232 749.7016457 1.083579251 0.115804673 0.653299549 1 3.732724375 3.977020061 23043 TRAF2 and NCK interacting kinase "GO:0000165,GO:0001934,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006468,GO:0007010,GO:0007165,GO:0007256,GO:0016055,GO:0016324,GO:0030033,GO:0031098,GO:0031532,GO:0032147,GO:0035556,GO:0046777,GO:0048812,GO:0048814,GO:0055037,GO:0070062,GO:0072659,GO:0098793,GO:0098978,GO:0099092,GO:0106310,GO:0106311" "MAPK cascade|positive regulation of protein phosphorylation|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|protein phosphorylation|cytoskeleton organization|signal transduction|activation of JNKK activity|Wnt signaling pathway|apical plasma membrane|microvillus assembly|stress-activated protein kinase signaling cascade|actin cytoskeleton reorganization|activation of protein kinase activity|intracellular signal transduction|protein autophosphorylation|neuron projection morphogenesis|regulation of dendrite morphogenesis|recycling endosome|extracellular exosome|protein localization to plasma membrane|presynapse|glutamatergic synapse|postsynaptic density, intracellular component|protein serine kinase activity|protein threonine kinase activity" TNIP1 7076.490414 7405.666017 6747.314811 0.911101688 -0.134316012 0.583036057 1 110.2138272 98.73567819 10318 TNFAIP3 interacting protein 1 "GO:0002755,GO:0005515,GO:0005654,GO:0005829,GO:0006412,GO:0006952,GO:0006954,GO:0007159,GO:0009101,GO:0016579,GO:0031593,GO:0042802,GO:0043124,GO:0045071,GO:0045944,GO:0050729,GO:0051019,GO:0070373,GO:0085032,GO:1903003" MyD88-dependent toll-like receptor signaling pathway|protein binding|nucleoplasm|cytosol|translation|defense response|inflammatory response|leukocyte cell-cell adhesion|glycoprotein biosynthetic process|protein deubiquitination|polyubiquitin modification-dependent protein binding|identical protein binding|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of viral genome replication|positive regulation of transcription by RNA polymerase II|positive regulation of inflammatory response|mitogen-activated protein kinase binding|negative regulation of ERK1 and ERK2 cascade|modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade|positive regulation of protein deubiquitination hsa05131 Shigellosis TNIP2 838.3507915 838.5735894 838.1279936 0.999468626 -0.000766814 1 1 22.25416769 21.87014694 79155 TNFAIP3 interacting protein 2 "GO:0005515,GO:0005654,GO:0005829,GO:0006915,GO:0006954,GO:0016579,GO:0019901,GO:0023035,GO:0031593,GO:0034134,GO:0034138,GO:0034162,GO:0043032,GO:0043123,GO:0045944,GO:0046872,GO:0050821,GO:0050871,GO:0051403,GO:0070498,GO:0070530,GO:0071222,GO:2000352" protein binding|nucleoplasm|cytosol|apoptotic process|inflammatory response|protein deubiquitination|protein kinase binding|CD40 signaling pathway|polyubiquitin modification-dependent protein binding|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 9 signaling pathway|positive regulation of macrophage activation|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription by RNA polymerase II|metal ion binding|protein stabilization|positive regulation of B cell activation|stress-activated MAPK cascade|interleukin-1-mediated signaling pathway|K63-linked polyubiquitin modification-dependent protein binding|cellular response to lipopolysaccharide|negative regulation of endothelial cell apoptotic process TNIP3 21.37314398 31.21241648 11.53387147 0.369528309 -1.436243205 0.086041329 1 0.387383558 0.140753783 79931 TNFAIP3 interacting protein 3 "GO:0002756,GO:0005515,GO:0005829,GO:0006954,GO:0016579,GO:0031593,GO:0034142,GO:0043124,GO:0045944,GO:0071222" MyD88-independent toll-like receptor signaling pathway|protein binding|cytosol|inflammatory response|protein deubiquitination|polyubiquitin modification-dependent protein binding|toll-like receptor 4 signaling pathway|negative regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription by RNA polymerase II|cellular response to lipopolysaccharide TNK1 110.9927769 150.860013 71.12554074 0.471467152 -1.084770834 0.016543799 0.766903206 2.657135849 1.23178916 8711 tyrosine kinase non receptor 1 "GO:0004713,GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0007169,GO:0016020,GO:0030154,GO:0031234,GO:0038083,GO:0042127,GO:0045087,GO:0046777" protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|protein binding|ATP binding|cytoplasm|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|membrane|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|peptidyl-tyrosine autophosphorylation|regulation of cell population proliferation|innate immune response|protein autophosphorylation TNK2 674.5592181 626.3291574 722.7892789 1.154008672 0.206654065 0.424187799 1 5.436011707 6.168231065 10188 tyrosine kinase non receptor 2 "GO:0004712,GO:0004713,GO:0004715,GO:0005095,GO:0005102,GO:0005154,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005768,GO:0005829,GO:0005886,GO:0005905,GO:0005912,GO:0006897,GO:0007166,GO:0007169,GO:0007264,GO:0016020,GO:0016310,GO:0030136,GO:0030154,GO:0030659,GO:0031234,GO:0031625,GO:0034260,GO:0038083,GO:0042127,GO:0042802,GO:0045087,GO:0046872,GO:0048471,GO:0050699,GO:0050731,GO:0070436,GO:0097268,GO:0106310,GO:0106311,GO:2000369" protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|GTPase inhibitor activity|signaling receptor binding|epidermal growth factor receptor binding|protein binding|ATP binding|nucleus|cytoplasm|endosome|cytosol|plasma membrane|clathrin-coated pit|adherens junction|endocytosis|cell surface receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|small GTPase mediated signal transduction|membrane|phosphorylation|clathrin-coated vesicle|cell differentiation|cytoplasmic vesicle membrane|extrinsic component of cytoplasmic side of plasma membrane|ubiquitin protein ligase binding|negative regulation of GTPase activity|peptidyl-tyrosine autophosphorylation|regulation of cell population proliferation|identical protein binding|innate immune response|metal ion binding|perinuclear region of cytoplasm|WW domain binding|positive regulation of peptidyl-tyrosine phosphorylation|Grb2-EGFR complex|cytoophidium|protein serine kinase activity|protein threonine kinase activity|regulation of clathrin-dependent endocytosis TNKS 1509.139613 1479.468541 1538.810686 1.040110447 0.056736733 0.814408782 1 5.681960053 5.810972406 8658 tankyrase "GO:0000139,GO:0000209,GO:0000242,GO:0000781,GO:0003950,GO:0005515,GO:0005634,GO:0005643,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006471,GO:0007052,GO:0008270,GO:0015031,GO:0016055,GO:0016604,GO:0018105,GO:0018107,GO:0031670,GO:0031965,GO:0032210,GO:0032212,GO:0042393,GO:0045944,GO:0051028,GO:0051225,GO:0051301,GO:0051973,GO:0070198,GO:0070212,GO:0070213,GO:0090263,GO:0097431,GO:1904355,GO:1904357,GO:1904743,GO:1904908,GO:1990404" "Golgi membrane|protein polyubiquitination|pericentriolar material|chromosome, telomeric region|NAD+ ADP-ribosyltransferase activity|protein binding|nucleus|nuclear pore|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|protein ADP-ribosylation|mitotic spindle organization|zinc ion binding|protein transport|Wnt signaling pathway|nuclear body|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|cellular response to nutrient|nuclear membrane|regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance via telomerase|histone binding|positive regulation of transcription by RNA polymerase II|mRNA transport|spindle assembly|cell division|positive regulation of telomerase activity|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein auto-ADP-ribosylation|positive regulation of canonical Wnt signaling pathway|mitotic spindle pole|positive regulation of telomere capping|negative regulation of telomere maintenance via telomere lengthening|negative regulation of telomeric DNA binding|negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric|protein ADP-ribosylase activity" TNKS1BP1 2723.958527 2776.864653 2671.052402 0.961895064 -0.056048581 0.813921009 1 23.89489888 22.59977272 85456 tankyrase 1 binding protein 1 "GO:0000289,GO:0000792,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0006302,GO:0006977,GO:0007004,GO:0010800,GO:0015629,GO:0019899,GO:0030014,GO:0031954,GO:0033138,GO:0044877,GO:0045296,GO:0071479,GO:0071532" "nuclear-transcribed mRNA poly(A) tail shortening|heterochromatin|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|adherens junction|double-strand break repair|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|telomere maintenance via telomerase|positive regulation of peptidyl-threonine phosphorylation|actin cytoskeleton|enzyme binding|CCR4-NOT complex|positive regulation of protein autophosphorylation|positive regulation of peptidyl-serine phosphorylation|protein-containing complex binding|cadherin binding|cellular response to ionizing radiation|ankyrin repeat binding" TNKS2 6350.078464 6755.40734 5944.749588 0.879998687 -0.184426724 0.447845931 1 43.11452689 37.30584036 80351 tankyrase 2 "GO:0000139,GO:0000209,GO:0000242,GO:0000781,GO:0003950,GO:0005515,GO:0005634,GO:0005635,GO:0005737,GO:0005829,GO:0006471,GO:0016055,GO:0019899,GO:0032212,GO:0035264,GO:0040014,GO:0046872,GO:0048471,GO:0070198,GO:0070212,GO:0070213,GO:0090263,GO:1904355,GO:1904357,GO:1990404" "Golgi membrane|protein polyubiquitination|pericentriolar material|chromosome, telomeric region|NAD+ ADP-ribosyltransferase activity|protein binding|nucleus|nuclear envelope|cytoplasm|cytosol|protein ADP-ribosylation|Wnt signaling pathway|enzyme binding|positive regulation of telomere maintenance via telomerase|multicellular organism growth|regulation of multicellular organism growth|metal ion binding|perinuclear region of cytoplasm|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein auto-ADP-ribosylation|positive regulation of canonical Wnt signaling pathway|positive regulation of telomere capping|negative regulation of telomere maintenance via telomere lengthening|protein ADP-ribosylase activity" TNNC1 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.242467147 0.146831943 7134 "troponin C1, slow skeletal and cardiac type" "GO:0002086,GO:0003009,GO:0005509,GO:0005515,GO:0005829,GO:0005861,GO:0006937,GO:0010038,GO:0014883,GO:0030049,GO:0031013,GO:0031014,GO:0032972,GO:0042803,GO:0043462,GO:0048306,GO:0051015,GO:0055010,GO:0060048,GO:1990584" diaphragm contraction|skeletal muscle contraction|calcium ion binding|protein binding|cytosol|troponin complex|regulation of muscle contraction|response to metal ion|transition between fast and slow fiber|muscle filament sliding|troponin I binding|troponin T binding|regulation of muscle filament sliding speed|protein homodimerization activity|regulation of ATPase activity|calcium-dependent protein binding|actin filament binding|ventricular cardiac muscle tissue morphogenesis|cardiac muscle contraction|cardiac Troponin complex "hsa04020,hsa04260,hsa04261,hsa05410,hsa05414" Calcium signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Hypertrophic cardiomyopathy|Dilated cardiomyopathy TNNC2 2.601034707 5.202069413 0 0 #NAME? 0.147074026 1 0.365295899 0 7125 "troponin C2, fast skeletal type" "GO:0003009,GO:0003779,GO:0005509,GO:0005515,GO:0005829,GO:0005861,GO:0006937,GO:0030049,GO:0048306,GO:0051015" skeletal muscle contraction|actin binding|calcium ion binding|protein binding|cytosol|troponin complex|regulation of muscle contraction|muscle filament sliding|calcium-dependent protein binding|actin filament binding hsa04020 Calcium signaling pathway TNNI3 21.97763926 21.84869154 22.10658699 1.011803702 0.016929423 1 1 1.383184473 1.376092247 7137 "troponin I3, cardiac type" "GO:0001570,GO:0001980,GO:0003009,GO:0003779,GO:0005515,GO:0005829,GO:0005861,GO:0006874,GO:0006936,GO:0007507,GO:0010882,GO:0019855,GO:0019901,GO:0019904,GO:0030017,GO:0030049,GO:0030172,GO:0031014,GO:0032780,GO:0046872,GO:0048306,GO:0051015,GO:0055010,GO:0060047,GO:0060048,GO:0097512,GO:1990584" vasculogenesis|regulation of systemic arterial blood pressure by ischemic conditions|skeletal muscle contraction|actin binding|protein binding|cytosol|troponin complex|cellular calcium ion homeostasis|muscle contraction|heart development|regulation of cardiac muscle contraction by calcium ion signaling|calcium channel inhibitor activity|protein kinase binding|protein domain specific binding|sarcomere|muscle filament sliding|troponin C binding|troponin T binding|negative regulation of ATPase activity|metal ion binding|calcium-dependent protein binding|actin filament binding|ventricular cardiac muscle tissue morphogenesis|heart contraction|cardiac muscle contraction|cardiac myofibril|cardiac Troponin complex "hsa04024,hsa04260,hsa04261,hsa05410,hsa05414" cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Hypertrophic cardiomyopathy|Dilated cardiomyopathy TNNT1 1369.976404 1270.345351 1469.607457 1.156856642 0.210210096 0.381336522 1 55.79917413 63.47146086 7138 "troponin T1, slow skeletal type" "GO:0003009,GO:0005515,GO:0005523,GO:0005829,GO:0005861,GO:0006936,GO:0014883,GO:0030049,GO:0031014,GO:0031444,GO:0045214,GO:0045932" skeletal muscle contraction|protein binding|tropomyosin binding|cytosol|troponin complex|muscle contraction|transition between fast and slow fiber|muscle filament sliding|troponin T binding|slow-twitch skeletal muscle fiber contraction|sarcomere organization|negative regulation of muscle contraction TNPO1 6308.432955 6545.243736 6071.622174 0.92763882 -0.1083649 0.655697935 1 35.89268686 32.73829542 3842 transportin 1 "GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005929,GO:0006606,GO:0008139,GO:0016032,GO:0035735,GO:0043488,GO:0061608,GO:0070062" RNA binding|protein binding|nucleus|cytoplasm|cytosol|cilium|protein import into nucleus|nuclear localization sequence binding|viral process|intraciliary transport involved in cilium assembly|regulation of mRNA stability|nuclear import signal receptor activity|extracellular exosome TNPO2 1980.10799 1971.584308 1988.631673 1.008646531 0.012420687 0.960475748 1 19.99996785 19.83533207 30000 transportin 2 "GO:0005515,GO:0005634,GO:0005737,GO:0006606,GO:0008139,GO:0061608" protein binding|nucleus|cytoplasm|protein import into nucleus|nuclear localization sequence binding|nuclear import signal receptor activity TNPO3 2223.793781 2287.870128 2159.717433 0.943986027 -0.08316259 0.726260533 1 27.58685581 25.6058354 23534 transportin 3 "GO:0005515,GO:0005635,GO:0005642,GO:0005737,GO:0006606,GO:0031267,GO:0042802,GO:0043231,GO:0061608" protein binding|nuclear envelope|annulate lamellae|cytoplasm|protein import into nucleus|small GTPase binding|identical protein binding|intracellular membrane-bounded organelle|nuclear import signal receptor activity TNRC18 2605.879155 2919.401355 2292.356955 0.785214733 -0.348840853 0.140137879 1 11.18953495 8.639162746 84629 trinucleotide repeat containing 18 "GO:0003682,GO:0005654,GO:0005739,GO:0005829,GO:0031965" chromatin binding|nucleoplasm|mitochondrion|cytosol|nuclear membrane TNRC6A 1543.49155 1800.956431 1286.026669 0.714079834 -0.485842719 0.041581981 1 12.60177458 8.84809249 27327 trinucleotide repeat containing adaptor 6A "GO:0000932,GO:0003723,GO:0005515,GO:0005654,GO:0005794,GO:0005829,GO:0007223,GO:0009267,GO:0010628,GO:0010629,GO:0016442,GO:0035194,GO:0035195,GO:0035278,GO:0043231,GO:0045652,GO:0060213,GO:0060964" "P-body|RNA binding|protein binding|nucleoplasm|Golgi apparatus|cytosol|Wnt signaling pathway, calcium modulating pathway|cellular response to starvation|positive regulation of gene expression|negative regulation of gene expression|RISC complex|post-transcriptional gene silencing by RNA|gene silencing by miRNA|miRNA mediated inhibition of translation|intracellular membrane-bounded organelle|regulation of megakaryocyte differentiation|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of gene silencing by miRNA" TNRC6B 769.9998926 810.4824146 729.5173706 0.900102652 -0.151838553 0.550424998 1 2.315770257 2.04955082 23112 trinucleotide repeat containing adaptor 6B "GO:0000932,GO:0003723,GO:0005515,GO:0005654,GO:0005829,GO:0007223,GO:0010628,GO:0010629,GO:0031047,GO:0035194,GO:0035195,GO:0035278,GO:0045652,GO:0060213,GO:1900153,GO:1905618" "P-body|RNA binding|protein binding|nucleoplasm|cytosol|Wnt signaling pathway, calcium modulating pathway|positive regulation of gene expression|negative regulation of gene expression|gene silencing by RNA|post-transcriptional gene silencing by RNA|gene silencing by miRNA|miRNA mediated inhibition of translation|regulation of megakaryocyte differentiation|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|positive regulation of miRNA mediated inhibition of translation" TNRC6C 306.2005563 317.3262342 295.0748785 0.929878613 -0.104885697 0.745370897 1 1.281895231 1.172060337 57690 trinucleotide repeat containing adaptor 6C "GO:0000932,GO:0003723,GO:0005515,GO:0005654,GO:0005829,GO:0007223,GO:0010628,GO:0010629,GO:0035194,GO:0035195,GO:0035278,GO:0045652,GO:0060213,GO:1900153" "P-body|RNA binding|protein binding|nucleoplasm|cytosol|Wnt signaling pathway, calcium modulating pathway|positive regulation of gene expression|negative regulation of gene expression|post-transcriptional gene silencing by RNA|gene silencing by miRNA|miRNA mediated inhibition of translation|regulation of megakaryocyte differentiation|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" TNS1 44.15845376 36.41448589 51.90242162 1.425323476 0.511289375 0.426046167 1 0.133528527 0.187136575 7145 tensin 1 "GO:0003723,GO:0003779,GO:0005515,GO:0005737,GO:0005856,GO:0005925,GO:0009986" RNA binding|actin binding|protein binding|cytoplasm|cytoskeleton|focal adhesion|cell surface TNS2 107.3959877 132.1325631 82.65941222 0.62557942 -0.676735042 0.138001925 1 1.048575768 0.644990695 23371 tensin 2 "GO:0001822,GO:0004725,GO:0005515,GO:0005886,GO:0005925,GO:0008285,GO:0014850,GO:0019725,GO:0019900,GO:0032963,GO:0035264,GO:0035335,GO:0035556,GO:0042802,GO:0046627,GO:0046872,GO:0048871" kidney development|protein tyrosine phosphatase activity|protein binding|plasma membrane|focal adhesion|negative regulation of cell population proliferation|response to muscle activity|cellular homeostasis|kinase binding|collagen metabolic process|multicellular organism growth|peptidyl-tyrosine dephosphorylation|intracellular signal transduction|identical protein binding|negative regulation of insulin receptor signaling pathway|metal ion binding|multicellular organismal homeostasis TNS3 1562.704608 1825.926364 1299.482853 0.71168415 -0.490690989 0.039492696 1 7.805698025 5.462232957 64759 tensin 3 "GO:0005515,GO:0005829,GO:0005925" protein binding|cytosol|focal adhesion TNXB 12.16793489 16.64662212 7.689247648 0.461910386 -1.11431511 0.300886484 1 0.063918241 0.029030447 7148 tenascin XB "GO:0005178,GO:0005201,GO:0005515,GO:0005576,GO:0005615,GO:0007155,GO:0008201,GO:0030036,GO:0030199,GO:0031012,GO:0032963,GO:0048251,GO:0062023,GO:0070062,GO:0098633" integrin binding|extracellular matrix structural constituent|protein binding|extracellular region|extracellular space|cell adhesion|heparin binding|actin cytoskeleton organization|collagen fibril organization|extracellular matrix|collagen metabolic process|elastic fiber assembly|collagen-containing extracellular matrix|extracellular exosome|collagen fibril binding "hsa04151,hsa04510,hsa04512,hsa05165,hsa05206" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Human papillomavirus infection|MicroRNAs in cancer TOB1 291.1195855 274.669265 307.5699059 1.119782754 0.163218866 0.613597587 1 5.814594944 6.402128979 10140 "transducer of ERBB2, 1" "GO:0003714,GO:0005515,GO:0005634,GO:0005737,GO:0008285,GO:0010468,GO:0017148,GO:0030014,GO:0030514,GO:0030971,GO:0045668,GO:0045892,GO:0046332,GO:0060212,GO:0060213,GO:0060390,GO:1900153" "transcription corepressor activity|protein binding|nucleus|cytoplasm|negative regulation of cell population proliferation|regulation of gene expression|negative regulation of translation|CCR4-NOT complex|negative regulation of BMP signaling pathway|receptor tyrosine kinase binding|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|SMAD binding|negative regulation of nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of SMAD protein signal transduction|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" hsa03018 RNA degradation TOB2 1305.657598 1373.346325 1237.968871 0.901425117 -0.149720446 0.534962597 1 9.143334489 8.104112126 10766 "transducer of ERBB2, 2" "GO:0003714,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007292,GO:0008285,GO:0010468,GO:0042809,GO:0045671,GO:0045778,GO:0045892" "transcription corepressor activity|protein binding|nucleus|cytoplasm|cytosol|female gamete generation|negative regulation of cell population proliferation|regulation of gene expression|vitamin D receptor binding|negative regulation of osteoclast differentiation|positive regulation of ossification|negative regulation of transcription, DNA-templated" hsa03018 RNA degradation TOE1 220.2519402 230.9718819 209.5319984 0.907175352 -0.140546651 0.697496933 1 5.545004422 4.946116228 114034 "target of EGR1, exonuclease" "GO:0000175,GO:0003723,GO:0004535,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0015030,GO:0016604,GO:0016607,GO:0017069,GO:0034472,GO:0046872,GO:0090503" "3'-5'-exoribonuclease activity|RNA binding|poly(A)-specific ribonuclease activity|protein binding|nucleoplasm|nucleolus|cytoplasm|Cajal body|nuclear body|nuclear speck|snRNA binding|snRNA 3'-end processing|metal ion binding|RNA phosphodiester bond hydrolysis, exonucleolytic" TOGARAM1 362.3533379 403.6805865 321.0260893 0.795247778 -0.33052366 0.266967511 1 3.709313183 2.900461771 23116 TOG array regulator of axonemal microtubules 1 "GO:0000226,GO:0005815,GO:0005874,GO:0005876,GO:0005881,GO:0005929,GO:0008017,GO:0031110,GO:0031116,GO:0035082,GO:0036064,GO:0072686,GO:0090307,GO:1905515" microtubule cytoskeleton organization|microtubule organizing center|microtubule|spindle microtubule|cytoplasmic microtubule|cilium|microtubule binding|regulation of microtubule polymerization or depolymerization|positive regulation of microtubule polymerization|axoneme assembly|ciliary basal body|mitotic spindle|mitotic spindle assembly|non-motile cilium assembly TOLLIP 1125.363442 1068.505057 1182.221826 1.106426046 0.145907024 0.55041499 1 13.35147532 14.5252236 54472 toll interacting protein "GO:0005150,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0006511,GO:0006914,GO:0006954,GO:0007165,GO:0016310,GO:0016604,GO:0019900,GO:0030855,GO:0031624,GO:0031625,GO:0032183,GO:0032991,GO:0033235,GO:0035325,GO:0035578,GO:0035580,GO:0036010,GO:0043130,GO:0043312,GO:0045087,GO:0045321,GO:0048471,GO:0070062,GO:0070498" "interleukin-1, type I receptor binding|protein binding|extracellular region|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|autophagy|inflammatory response|signal transduction|phosphorylation|nuclear body|kinase binding|epithelial cell differentiation|ubiquitin conjugating enzyme binding|ubiquitin protein ligase binding|SUMO binding|protein-containing complex|positive regulation of protein sumoylation|Toll-like receptor binding|azurophil granule lumen|specific granule lumen|protein localization to endosome|ubiquitin binding|neutrophil degranulation|innate immune response|leukocyte activation|perinuclear region of cytoplasm|extracellular exosome|interleukin-1-mediated signaling pathway" hsa04620 Toll-like receptor signaling pathway TOM1 697.0960789 751.1788233 643.0133346 0.856005674 -0.224307736 0.382713759 1 15.87684483 13.36324781 10043 target of myb1 membrane trafficking protein "GO:0005515,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0006886,GO:0006897,GO:0007165,GO:0015031,GO:0016020,GO:0016197,GO:0030276,GO:0035577,GO:0035579,GO:0043312,GO:0070062" protein binding|cytoplasm|endosome|early endosome|cytosol|plasma membrane|intracellular protein transport|endocytosis|signal transduction|protein transport|membrane|endosomal transport|clathrin binding|azurophil granule membrane|specific granule membrane|neutrophil degranulation|extracellular exosome TOM1L1 1644.195888 1643.853935 1644.537841 1.000416038 0.000600092 1 1 28.70728508 28.23865102 10040 target of myb1 like 1 membrane trafficking protein "GO:0005515,GO:0005737,GO:0005764,GO:0005768,GO:0005795,GO:0005829,GO:0006886,GO:0007165,GO:0010008,GO:0016020,GO:0017124,GO:0019901,GO:0030276,GO:0030295,GO:0031954,GO:0032147,GO:0043130,GO:0043162,GO:0045839,GO:0070062,GO:2000278" protein binding|cytoplasm|lysosome|endosome|Golgi stack|cytosol|intracellular protein transport|signal transduction|endosome membrane|membrane|SH3 domain binding|protein kinase binding|clathrin binding|protein kinase activator activity|positive regulation of protein autophosphorylation|activation of protein kinase activity|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|negative regulation of mitotic nuclear division|extracellular exosome|regulation of DNA biosynthetic process TOM1L2 820.2674659 792.7953786 847.7395532 1.069304358 0.096672548 0.703406208 1 7.263524851 7.636949909 146691 target of myb1 like 2 membrane trafficking protein "GO:0005515,GO:0005768,GO:0006886,GO:0007165,GO:0016020,GO:0019901,GO:0030276,GO:0045839,GO:0070062" protein binding|endosome|intracellular protein transport|signal transduction|membrane|protein kinase binding|clathrin binding|negative regulation of mitotic nuclear division|extracellular exosome TOMM20 5377.380918 5581.82048 5172.941355 0.92674807 -0.10975089 0.648903438 1 90.7375876 82.68373708 9804 translocase of outer mitochondrial membrane 20 "GO:0005515,GO:0005739,GO:0005741,GO:0005742,GO:0006626,GO:0008320,GO:0014850,GO:0015450,GO:0016031,GO:0016236,GO:0016579,GO:0030150,GO:0030943,GO:0031307,GO:0044233,GO:0051082,GO:1905242" "protein binding|mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|protein targeting to mitochondrion|protein transmembrane transporter activity|response to muscle activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|tRNA import into mitochondrion|macroautophagy|protein deubiquitination|protein import into mitochondrial matrix|mitochondrion targeting sequence binding|integral component of mitochondrial outer membrane|mitochondria-associated endoplasmic reticulum membrane|unfolded protein binding|response to 3,3',5-triiodo-L-thyronine" TOMM22 1049.546592 983.1911191 1115.902065 1.134979805 0.182666628 0.45670601 1 25.83510734 28.83165569 56993 translocase of outer mitochondrial membrane 22 "GO:0005515,GO:0005739,GO:0005741,GO:0005742,GO:0006626,GO:0008320,GO:0016020,GO:0016021,GO:0016236,GO:0043065,GO:0045040,GO:0071806" protein binding|mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|protein targeting to mitochondrion|protein transmembrane transporter activity|membrane|integral component of membrane|macroautophagy|positive regulation of apoptotic process|protein insertion into mitochondrial outer membrane|protein transmembrane transport TOMM34 3010.030143 2956.856254 3063.204032 1.035966502 0.050977355 0.830699172 1 62.47109415 63.63499347 10953 translocase of outer mitochondrial membrane 34 "GO:0005515,GO:0005634,GO:0005739,GO:0005741,GO:0005829,GO:0006626,GO:0016020,GO:0016021,GO:0031072,GO:0043231" protein binding|nucleus|mitochondrion|mitochondrial outer membrane|cytosol|protein targeting to mitochondrion|membrane|integral component of membrane|heat shock protein binding|intracellular membrane-bounded organelle TOMM40 870.4947958 874.9880753 866.0015164 0.989729507 -0.014893804 0.957373232 1 25.54513426 24.85970016 10452 translocase of outer mitochondrial membrane 40 "GO:0005515,GO:0005739,GO:0005741,GO:0005742,GO:0005743,GO:0005829,GO:0006626,GO:0008320,GO:0015288,GO:0016021,GO:0016236,GO:0030150,GO:0031307,GO:0044233,GO:0046930" protein binding|mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|mitochondrial inner membrane|cytosol|protein targeting to mitochondrion|protein transmembrane transporter activity|porin activity|integral component of membrane|macroautophagy|protein import into mitochondrial matrix|integral component of mitochondrial outer membrane|mitochondria-associated endoplasmic reticulum membrane|pore complex "hsa05014,hsa05022" Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases TOMM40L 446.7859926 475.4691444 418.1028409 0.879347999 -0.185493874 0.51219202 1 8.728900709 7.547298238 84134 translocase of outer mitochondrial membrane 40 like "GO:0003674,GO:0005742,GO:0008150,GO:0008320,GO:0015288,GO:0030150,GO:0030943,GO:0032991,GO:0046930,GO:0070678" molecular_function|mitochondrial outer membrane translocase complex|biological_process|protein transmembrane transporter activity|porin activity|protein import into mitochondrial matrix|mitochondrion targeting sequence binding|protein-containing complex|pore complex|preprotein binding "hsa05014,hsa05022" Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases TOMM5 1266.657783 1156.940237 1376.375329 1.189668476 0.250559595 0.299070078 1 71.38008568 83.49763933 401505 translocase of outer mitochondrial membrane 5 "GO:0005739,GO:0005741,GO:0005742,GO:0006626,GO:0016021,GO:0016236" mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|protein targeting to mitochondrion|integral component of membrane|macroautophagy TOMM6 1075.517924 933.2512527 1217.784596 1.304883966 0.383921524 0.116068628 1 82.73405999 106.1518116 100188893 translocase of outer mitochondrial membrane 6 "GO:0005515,GO:0005739,GO:0005741,GO:0005742,GO:0015031,GO:0016236" protein binding|mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|protein transport|macroautophagy TOMM7 1429.205768 1374.386739 1484.024796 1.079772348 0.110727176 0.645170027 1 169.0057471 179.4340473 54543 translocase of outer mitochondrial membrane 7 "GO:0005515,GO:0005739,GO:0005741,GO:0005742,GO:0006626,GO:0008320,GO:0016021,GO:0016236,GO:0030150,GO:0031647,GO:0098779,GO:1903955" protein binding|mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|protein targeting to mitochondrion|protein transmembrane transporter activity|integral component of membrane|macroautophagy|protein import into mitochondrial matrix|regulation of protein stability|positive regulation of mitophagy in response to mitochondrial depolarization|positive regulation of protein targeting to mitochondrion hsa04137 Mitophagy - animal TOMM70 2227.535223 2146.37384 2308.696606 1.075626512 0.10517722 0.657435987 1 27.93854316 29.54856761 9868 translocase of outer mitochondrial membrane 70 "GO:0002218,GO:0002230,GO:0005515,GO:0005739,GO:0005741,GO:0005742,GO:0006626,GO:0008320,GO:0016020,GO:0016021,GO:0016236,GO:0030150,GO:0030943,GO:0032728,GO:0042981,GO:0045039,GO:0070062,GO:0098586" activation of innate immune response|positive regulation of defense response to virus by host|protein binding|mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|protein targeting to mitochondrion|protein transmembrane transporter activity|membrane|integral component of membrane|macroautophagy|protein import into mitochondrial matrix|mitochondrion targeting sequence binding|positive regulation of interferon-beta production|regulation of apoptotic process|protein insertion into mitochondrial inner membrane|extracellular exosome|cellular response to virus TONSL 813.1971904 846.8969005 779.4974803 0.920416027 -0.11964199 0.636628526 1 9.861953098 8.925206717 4796 "tonsoku like, DNA repair protein" "GO:0000724,GO:0005515,GO:0005654,GO:0005662,GO:0005737,GO:0016604,GO:0031297,GO:0035101,GO:0042393,GO:0042555,GO:0043596" double-strand break repair via homologous recombination|protein binding|nucleoplasm|DNA replication factor A complex|cytoplasm|nuclear body|replication fork processing|FACT complex|histone binding|MCM complex|nuclear replication fork TOP1 3068.207803 3285.627041 2850.788565 0.867654341 -0.204807683 0.387245542 1 46.95979552 40.06306021 7150 DNA topoisomerase I "GO:0000228,GO:0000932,GO:0000978,GO:0001650,GO:0003677,GO:0003682,GO:0003690,GO:0003697,GO:0003723,GO:0003917,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006260,GO:0006265,GO:0006338,GO:0007059,GO:0007623,GO:0012501,GO:0016032,GO:0016310,GO:0018105,GO:0019904,GO:0032922,GO:0032993,GO:0040016,GO:0042493,GO:0043204,GO:0097100" "nuclear chromosome|P-body|RNA polymerase II cis-regulatory region sequence-specific DNA binding|fibrillar center|DNA binding|chromatin binding|double-stranded DNA binding|single-stranded DNA binding|RNA binding|DNA topoisomerase type I (single strand cut, ATP-independent) activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|DNA replication|DNA topological change|chromatin remodeling|chromosome segregation|circadian rhythm|programmed cell death|viral process|phosphorylation|peptidyl-serine phosphorylation|protein domain specific binding|circadian regulation of gene expression|protein-DNA complex|embryonic cleavage|response to drug|perikaryon|supercoiled DNA binding" other TOP1MT 1075.338673 1079.94961 1070.727735 0.991460828 -0.012372321 0.963789329 1 21.43359086 20.89496631 116447 DNA topoisomerase I mitochondrial "GO:0003677,GO:0003917,GO:0005654,GO:0005694,GO:0005739,GO:0006260,GO:0006265,GO:0042645" "DNA binding|DNA topoisomerase type I (single strand cut, ATP-independent) activity|nucleoplasm|chromosome|mitochondrion|DNA replication|DNA topological change|mitochondrial nucleoid" TOP2A 11791.71844 12283.1263 11300.31057 0.919986516 -0.120315378 0.637645359 1 112.5756268 101.8349876 7153 DNA topoisomerase II alpha "GO:0000228,GO:0000287,GO:0000712,GO:0000775,GO:0000793,GO:0000819,GO:0002244,GO:0003677,GO:0003682,GO:0003723,GO:0003918,GO:0005080,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005814,GO:0006265,GO:0006266,GO:0006974,GO:0007059,GO:0007143,GO:0008022,GO:0008094,GO:0008301,GO:0009330,GO:0019899,GO:0030263,GO:0032991,GO:0040016,GO:0042752,GO:0042803,GO:0042826,GO:0043065,GO:0043130,GO:0044774,GO:0045870,GO:0045944,GO:0046982,GO:0048511,GO:1905463,GO:1990904" "nuclear chromosome|magnesium ion binding|resolution of meiotic recombination intermediates|chromosome, centromeric region|condensed chromosome|sister chromatid segregation|hematopoietic progenitor cell differentiation|DNA binding|chromatin binding|RNA binding|DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity|protein kinase C binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centriole|DNA topological change|DNA ligation|cellular response to DNA damage stimulus|chromosome segregation|female meiotic nuclear division|protein C-terminus binding|DNA-dependent ATPase activity|DNA binding, bending|DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex|enzyme binding|apoptotic chromosome condensation|protein-containing complex|embryonic cleavage|regulation of circadian rhythm|protein homodimerization activity|histone deacetylase binding|positive regulation of apoptotic process|ubiquitin binding|mitotic DNA integrity checkpoint|positive regulation of single stranded viral RNA replication via double stranded DNA intermediate|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|rhythmic process|negative regulation of DNA duplex unwinding|ribonucleoprotein complex" hsa01524 Platinum drug resistance TOP2B 4492.134701 4243.848227 4740.421175 1.117010063 0.159642183 0.504444092 1 38.53775396 42.32672474 7155 DNA topoisomerase II beta "GO:0000712,GO:0000792,GO:0000819,GO:0001764,GO:0003677,GO:0003682,GO:0003918,GO:0005080,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006265,GO:0007409,GO:0008022,GO:0019899,GO:0030900,GO:0042826,GO:0044774,GO:0045870,GO:0046872,GO:0046982,GO:1990904" "resolution of meiotic recombination intermediates|heterochromatin|sister chromatid segregation|neuron migration|DNA binding|chromatin binding|DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity|protein kinase C binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytosol|DNA topological change|axonogenesis|protein C-terminus binding|enzyme binding|forebrain development|histone deacetylase binding|mitotic DNA integrity checkpoint|positive regulation of single stranded viral RNA replication via double stranded DNA intermediate|metal ion binding|protein heterodimerization activity|ribonucleoprotein complex" hsa01524 Platinum drug resistance TOP3A 853.4116407 931.170425 775.6528565 0.832986998 -0.263634119 0.291516936 1 6.133652698 5.023756516 7156 DNA topoisomerase III alpha "GO:0003677,GO:0003697,GO:0003916,GO:0003917,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005759,GO:0006260,GO:0006265,GO:0008270,GO:0016605,GO:0032042,GO:0051304,GO:0051321,GO:1901796" "DNA binding|single-stranded DNA binding|DNA topoisomerase activity|DNA topoisomerase type I (single strand cut, ATP-independent) activity|protein binding|nucleus|nucleoplasm|chromosome|mitochondrial matrix|DNA replication|DNA topological change|zinc ion binding|PML body|mitochondrial DNA metabolic process|chromosome separation|meiotic cell cycle|regulation of signal transduction by p53 class mediator" "hsa03440,hsa03460" Homologous recombination|Fanconi anemia pathway TOP3B 399.3874103 429.6909335 369.0838871 0.858952001 -0.219350581 0.451028734 1 6.668163822 5.631788481 8940 DNA topoisomerase III beta "GO:0000793,GO:0003677,GO:0003723,GO:0003916,GO:0003917,GO:0005515,GO:0005634,GO:0006265,GO:0007059" "condensed chromosome|DNA binding|RNA binding|DNA topoisomerase activity|DNA topoisomerase type I (single strand cut, ATP-independent) activity|protein binding|nucleus|DNA topological change|chromosome segregation" "hsa03440,hsa03460" Homologous recombination|Fanconi anemia pathway TOPBP1 2381.922214 2540.690701 2223.153726 0.875019429 -0.192613044 0.415409597 1 23.87603331 20.54239381 11073 DNA topoisomerase II binding protein 1 "GO:0000794,GO:0000922,GO:0001673,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005815,GO:0005886,GO:0006259,GO:0006260,GO:0006270,GO:0006281,GO:0006974,GO:0007095,GO:0008022,GO:0010212,GO:0015629,GO:0016604,GO:0016605,GO:0033314,GO:0042802,GO:0043231,GO:1901796" condensed nuclear chromosome|spindle pole|male germ cell nucleus|DNA binding|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|microtubule organizing center|plasma membrane|DNA metabolic process|DNA replication|DNA replication initiation|DNA repair|cellular response to DNA damage stimulus|mitotic G2 DNA damage checkpoint|protein C-terminus binding|response to ionizing radiation|actin cytoskeleton|nuclear body|PML body|mitotic DNA replication checkpoint|identical protein binding|intracellular membrane-bounded organelle|regulation of signal transduction by p53 class mediator hsa03440 Homologous recombination TOPORS 1290.026852 1303.638595 1276.41511 0.979117306 -0.030446378 0.902608017 1 16.8416354 16.21399993 10210 "TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase" "GO:0000151,GO:0000209,GO:0000922,GO:0000930,GO:0003677,GO:0003823,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005814,GO:0005868,GO:0006351,GO:0006511,GO:0006513,GO:0006974,GO:0008630,GO:0010842,GO:0016605,GO:0016607,GO:0016925,GO:0019789,GO:0030496,GO:0032391,GO:0034504,GO:0035845,GO:0036064,GO:0042127,GO:0042771,GO:0043066,GO:0043161,GO:0044547,GO:0045893,GO:0046548,GO:0046549,GO:0046872,GO:0051443,GO:0051457,GO:0061630,GO:0070936" "ubiquitin ligase complex|protein polyubiquitination|spindle pole|gamma-tubulin complex|DNA binding|antigen binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|centriole|cytoplasmic dynein complex|transcription, DNA-templated|ubiquitin-dependent protein catabolic process|protein monoubiquitination|cellular response to DNA damage stimulus|intrinsic apoptotic signaling pathway in response to DNA damage|retina layer formation|PML body|nuclear speck|protein sumoylation|SUMO transferase activity|midbody|photoreceptor connecting cilium|protein localization to nucleus|photoreceptor cell outer segment organization|ciliary basal body|regulation of cell population proliferation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|DNA topoisomerase binding|positive regulation of transcription, DNA-templated|retinal rod cell development|retinal cone cell development|metal ion binding|positive regulation of ubiquitin-protein transferase activity|maintenance of protein location in nucleus|ubiquitin protein ligase activity|protein K48-linked ubiquitination" TOR1A 1341.770144 1400.397086 1283.143201 0.916270973 -0.126153778 0.600883174 1 35.93106666 32.37167841 1861 torsin family 1 member A "GO:0000338,GO:0005515,GO:0005524,GO:0005635,GO:0005783,GO:0005788,GO:0005829,GO:0005856,GO:0006979,GO:0006996,GO:0006998,GO:0007155,GO:0008021,GO:0008092,GO:0016020,GO:0016887,GO:0019894,GO:0030141,GO:0030426,GO:0030659,GO:0031175,GO:0031965,GO:0034504,GO:0042406,GO:0042802,GO:0043231,GO:0044319,GO:0045104,GO:0048489,GO:0051082,GO:0051085,GO:0051584,GO:0051787,GO:0061077,GO:0070062,GO:0071712,GO:0071763,GO:0072321,GO:1900244,GO:2000008" "protein deneddylation|protein binding|ATP binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum lumen|cytosol|cytoskeleton|response to oxidative stress|organelle organization|nuclear envelope organization|cell adhesion|synaptic vesicle|cytoskeletal protein binding|membrane|ATPase activity|kinesin binding|secretory granule|growth cone|cytoplasmic vesicle membrane|neuron projection development|nuclear membrane|protein localization to nucleus|extrinsic component of endoplasmic reticulum membrane|identical protein binding|intracellular membrane-bounded organelle|wound healing, spreading of cells|intermediate filament cytoskeleton organization|synaptic vesicle transport|unfolded protein binding|chaperone cofactor-dependent protein refolding|regulation of dopamine uptake involved in synaptic transmission|misfolded protein binding|chaperone-mediated protein folding|extracellular exosome|ER-associated misfolded protein catabolic process|nuclear membrane organization|chaperone-mediated protein transport|positive regulation of synaptic vesicle endocytosis|regulation of protein localization to cell surface" TOR1AIP1 1330.454539 1355.659289 1305.249788 0.962815509 -0.054668714 0.822739451 1 18.98925057 17.97720128 26092 torsin 1A interacting protein 1 "GO:0001671,GO:0005515,GO:0005634,GO:0005637,GO:0008092,GO:0016021,GO:0031965,GO:0032781,GO:0034504,GO:0051117" ATPase activator activity|protein binding|nucleus|nuclear inner membrane|cytoskeletal protein binding|integral component of membrane|nuclear membrane|positive regulation of ATPase activity|protein localization to nucleus|ATPase binding TOR1AIP2 1754.360872 1861.300436 1647.421309 0.885091561 -0.176101388 0.458514099 1 5.938198431 5.167899798 163590 torsin 1A interacting protein 2 "GO:0001671,GO:0005515,GO:0005783,GO:0005789,GO:0007029,GO:0016021,GO:0031965,GO:0032781,GO:0051117,GO:0090435" ATPase activator activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum organization|integral component of membrane|nuclear membrane|positive regulation of ATPase activity|ATPase binding|protein localization to nuclear envelope TOR1B 893.7355315 942.6149777 844.8560853 0.896289689 -0.157962995 0.526801341 1 18.13468958 15.98194769 27348 torsin family 1 member B "GO:0005515,GO:0005524,GO:0005635,GO:0005783,GO:0005788,GO:0006986,GO:0007029,GO:0016887,GO:0019894,GO:0031965,GO:0034504,GO:0042802,GO:0051085,GO:0070062,GO:0071763" protein binding|ATP binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum lumen|response to unfolded protein|endoplasmic reticulum organization|ATPase activity|kinesin binding|nuclear membrane|protein localization to nucleus|identical protein binding|chaperone cofactor-dependent protein refolding|extracellular exosome|nuclear membrane organization TOR2A 144.950267 159.183324 130.71721 0.821174019 -0.284240111 0.495267039 1 3.428297594 2.768119871 27433 torsin family 2 member A "GO:0005524,GO:0005635,GO:0005788,GO:0016887,GO:0042802,GO:0051085" ATP binding|nuclear envelope|endoplasmic reticulum lumen|ATPase activity|identical protein binding|chaperone cofactor-dependent protein refolding TOR3A 651.8726736 674.188196 629.5571512 0.933800317 -0.098814016 0.707113828 1 17.71550217 16.26592117 64222 torsin family 3 member A "GO:0005524,GO:0005635,GO:0005783,GO:0005788,GO:0016887,GO:0070062" ATP binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum lumen|ATPase activity|extracellular exosome TOR4A 1676.642447 1625.126485 1728.158409 1.063399326 0.088683457 0.710629999 1 20.79357795 21.74186447 54863 torsin family 4 member A "GO:0002576,GO:0005524,GO:0005576,GO:0005635,GO:0005788,GO:0016021,GO:0016887,GO:0031093" platelet degranulation|ATP binding|extracellular region|nuclear envelope|endoplasmic reticulum lumen|integral component of membrane|ATPase activity|platelet alpha granule lumen TOX 2.52177678 3.121241648 1.922311912 0.615880514 -0.699277611 0.948776152 1 0.039454034 0.02389236 9760 thymocyte selection associated high mobility group box "GO:0001779,GO:0002362,GO:0002364,GO:0002521,GO:0005515,GO:0005634,GO:0006325,GO:0006357,GO:0010976,GO:0021895,GO:0031490,GO:0032825,GO:0043373,GO:0043375,GO:0048535,GO:0048541,GO:1901537,GO:1902232,GO:2000179" "natural killer cell differentiation|CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment|NK T cell lineage commitment|leukocyte differentiation|protein binding|nucleus|chromatin organization|regulation of transcription by RNA polymerase II|positive regulation of neuron projection development|cerebral cortex neuron differentiation|chromatin DNA binding|positive regulation of natural killer cell differentiation|CD4-positive, alpha-beta T cell lineage commitment|CD8-positive, alpha-beta T cell lineage commitment|lymph node development|Peyer's patch development|positive regulation of DNA demethylation|regulation of positive thymic T cell selection|positive regulation of neural precursor cell proliferation" TOX2 899.0709647 1019.605605 778.5363244 0.763566148 -0.389174951 0.116994884 1 19.17352966 14.3952733 84969 TOX high mobility group box family member 2 "GO:0003713,GO:0005634,GO:0005654,GO:0006357,GO:0031490,GO:0045944" transcription coactivator activity|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|chromatin DNA binding|positive regulation of transcription by RNA polymerase II TOX4 1798.658335 1850.896297 1746.420372 0.943553874 -0.083823201 0.725282842 1 21.88279432 20.30208582 9878 TOX high mobility group box family member 4 "GO:0000781,GO:0000785,GO:0005515,GO:0005634,GO:0006357,GO:0031490,GO:0072357" "chromosome, telomeric region|chromatin|protein binding|nucleus|regulation of transcription by RNA polymerase II|chromatin DNA binding|PTW/PP1 phosphatase complex" TP53 132.4451788 184.1532572 80.7371003 0.438423417 -1.189603237 0.005341941 0.442733617 3.547985877 1.52949057 7157 tumor protein p53 "GO:0000122,GO:0000733,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0000987,GO:0001046,GO:0001085,GO:0001094,GO:0001216,GO:0001228,GO:0001701,GO:0001756,GO:0001836,GO:0002020,GO:0002039,GO:0002244,GO:0002309,GO:0002326,GO:0002360,GO:0002931,GO:0003677,GO:0003682,GO:0003700,GO:0003730,GO:0005507,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005657,GO:0005667,GO:0005669,GO:0005730,GO:0005737,GO:0005739,GO:0005759,GO:0005783,GO:0005813,GO:0005829,GO:0006289,GO:0006302,GO:0006355,GO:0006357,GO:0006606,GO:0006914,GO:0006974,GO:0006977,GO:0006978,GO:0006983,GO:0007050,GO:0007179,GO:0007265,GO:0007369,GO:0007406,GO:0007569,GO:0008104,GO:0008134,GO:0008156,GO:0008270,GO:0008285,GO:0008340,GO:0009299,GO:0009303,GO:0009651,GO:0010165,GO:0010332,GO:0010628,GO:0010666,GO:0016032,GO:0016363,GO:0016579,GO:0016604,GO:0016605,GO:0019221,GO:0019899,GO:0019901,GO:0019903,GO:0021549,GO:0030308,GO:0030330,GO:0030512,GO:0030971,GO:0031065,GO:0031497,GO:0031571,GO:0031625,GO:0032991,GO:0033077,GO:0033209,GO:0034103,GO:0034644,GO:0035033,GO:0035035,GO:0035264,GO:0035690,GO:0035794,GO:0035861,GO:0036003,GO:0042149,GO:0042771,GO:0042802,GO:0042826,GO:0042981,GO:0043065,GO:0043066,GO:0043153,GO:0043504,GO:0043516,GO:0043525,GO:0043621,GO:0045861,GO:0045892,GO:0045893,GO:0045899,GO:0045944,GO:0046677,GO:0046827,GO:0046982,GO:0047485,GO:0048147,GO:0048512,GO:0048539,GO:0048568,GO:0050731,GO:0050821,GO:0051087,GO:0051097,GO:0051262,GO:0051402,GO:0051721,GO:0051974,GO:0060218,GO:0060333,GO:0060411,GO:0061419,GO:0062100,GO:0065003,GO:0070059,GO:0070245,GO:0070266,GO:0071158,GO:0071456,GO:0071479,GO:0071480,GO:0071494,GO:0071850,GO:0072331,GO:0072332,GO:0072717,GO:0090200,GO:0090343,GO:0090399,GO:0090403,GO:0097193,GO:0097252,GO:0097371,GO:0097718,GO:1900119,GO:1900740,GO:1901525,GO:1901796,GO:1902108,GO:1902253,GO:1902749,GO:1902895,GO:1903799,GO:1903800,GO:1904024,GO:1905856,GO:1990144,GO:1990248,GO:1990440,GO:1990841,GO:2000269,GO:2000378,GO:2000379,GO:2000772,GO:2001244" "negative regulation of transcription by RNA polymerase II|DNA strand renaturation|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|core promoter sequence-specific DNA binding|RNA polymerase II transcription factor binding|TFIID-class transcription factor complex binding|DNA-binding transcription activator activity|DNA-binding transcription activator activity, RNA polymerase II-specific|in utero embryonic development|somitogenesis|release of cytochrome c from mitochondria|protease binding|p53 binding|hematopoietic progenitor cell differentiation|T cell proliferation involved in immune response|B cell lineage commitment|T cell lineage commitment|response to ischemia|DNA binding|chromatin binding|DNA-binding transcription factor activity|mRNA 3'-UTR binding|copper ion binding|protein binding|ATP binding|nucleus|nucleoplasm|replication fork|transcription regulator complex|transcription factor TFIID complex|nucleolus|cytoplasm|mitochondrion|mitochondrial matrix|endoplasmic reticulum|centrosome|cytosol|nucleotide-excision repair|double-strand break repair|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|protein import into nucleus|autophagy|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|cell cycle arrest|transforming growth factor beta receptor signaling pathway|Ras protein signal transduction|gastrulation|negative regulation of neuroblast proliferation|cell aging|protein localization|transcription factor binding|negative regulation of DNA replication|zinc ion binding|negative regulation of cell population proliferation|determination of adult lifespan|mRNA transcription|rRNA transcription|response to salt stress|response to X-ray|response to gamma radiation|positive regulation of gene expression|positive regulation of cardiac muscle cell apoptotic process|viral process|nuclear matrix|protein deubiquitination|nuclear body|PML body|cytokine-mediated signaling pathway|enzyme binding|protein kinase binding|protein phosphatase binding|cerebellum development|negative regulation of cell growth|DNA damage response, signal transduction by p53 class mediator|negative regulation of transforming growth factor beta receptor signaling pathway|receptor tyrosine kinase binding|positive regulation of histone deacetylation|chromatin assembly|mitotic G1 DNA damage checkpoint|ubiquitin protein ligase binding|protein-containing complex|T cell differentiation in thymus|tumor necrosis factor-mediated signaling pathway|regulation of tissue remodeling|cellular response to UV|histone deacetylase regulator activity|histone acetyltransferase binding|multicellular organism growth|cellular response to drug|positive regulation of mitochondrial membrane permeability|site of double-strand break|positive regulation of transcription from RNA polymerase II promoter in response to stress|cellular response to glucose starvation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|identical protein binding|histone deacetylase binding|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|entrainment of circadian clock by photoperiod|mitochondrial DNA repair|regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of neuron apoptotic process|protein self-association|negative regulation of proteolysis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of RNA polymerase II transcription preinitiation complex assembly|positive regulation of transcription by RNA polymerase II|response to antibiotic|positive regulation of protein export from nucleus|protein heterodimerization activity|protein N-terminus binding|negative regulation of fibroblast proliferation|circadian behavior|bone marrow development|embryonic organ development|positive regulation of peptidyl-tyrosine phosphorylation|protein stabilization|chaperone binding|negative regulation of helicase activity|protein tetramerization|neuron apoptotic process|protein phosphatase 2A binding|negative regulation of telomerase activity|hematopoietic stem cell differentiation|interferon-gamma-mediated signaling pathway|cardiac septum morphogenesis|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|positive regulation of programmed necrotic cell death|protein-containing complex assembly|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|positive regulation of thymocyte apoptotic process|necroptotic process|positive regulation of cell cycle arrest|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to gamma radiation|cellular response to UV-C|mitotic cell cycle arrest|signal transduction by p53 class mediator|intrinsic apoptotic signaling pathway by p53 class mediator|cellular response to actinomycin D|positive regulation of release of cytochrome c from mitochondria|positive regulation of cell aging|replicative senescence|oxidative stress-induced premature senescence|intrinsic apoptotic signaling pathway|oligodendrocyte apoptotic process|MDM2/MDM4 family protein binding|disordered domain specific binding|positive regulation of execution phase of apoptosis|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|negative regulation of mitophagy|regulation of signal transduction by p53 class mediator|regulation of mitochondrial membrane permeability involved in apoptotic process|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|regulation of cell cycle G2/M phase transition|positive regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of production of miRNAs involved in gene silencing by miRNA|positive regulation of production of miRNAs involved in gene silencing by miRNA|negative regulation of glucose catabolic process to lactate via pyruvate|negative regulation of pentose-phosphate shunt|intrinsic apoptotic signaling pathway in response to hypoxia|regulation of transcription from RNA polymerase II promoter in response to DNA damage|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|promoter-specific chromatin binding|regulation of fibroblast apoptotic process|negative regulation of reactive oxygen species metabolic process|positive regulation of reactive oxygen species metabolic process|regulation of cellular senescence|positive regulation of intrinsic apoptotic signaling pathway" "hsa01522,hsa01524,hsa04010,hsa04071,hsa04110,hsa04115,hsa04137,hsa04151,hsa04210,hsa04211,hsa04216,hsa04218,hsa04310,hsa04722,hsa04919,hsa05012,hsa05014,hsa05016,hsa05131,hsa05160,hsa05161,hsa05162,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05200,hsa05202,hsa05203,hsa05205,hsa05206,hsa05210,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05217,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05418" Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|Sphingolipid signaling pathway|Cell cycle|p53 signaling pathway|Mitophagy - animal|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Ferroptosis|Cellular senescence|Wnt signaling pathway|Neurotrophin signaling pathway|Thyroid hormone signaling pathway|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Shigellosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Fluid shear stress and atherosclerosis P53 TP53BP1 2711.458469 2789.349619 2633.567319 0.944151031 -0.082910436 0.72690768 1 12.88294786 11.95990967 7158 tumor protein p53 binding protein 1 "GO:0000077,GO:0000777,GO:0000781,GO:0001102,GO:0002039,GO:0003684,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0005737,GO:0006303,GO:0006974,GO:0016604,GO:0035064,GO:0035861,GO:0042162,GO:0042393,GO:0045830,GO:0045893,GO:0045944,GO:0051091,GO:0051260,GO:0061649,GO:0071481,GO:1990391,GO:2000042" "DNA damage checkpoint|condensed chromosome kinetochore|chromosome, telomeric region|RNA polymerase II activating transcription factor binding|p53 binding|damaged DNA binding|transcription coregulator activity|protein binding|nucleus|nucleoplasm|replication fork|cytoplasm|double-strand break repair via nonhomologous end joining|cellular response to DNA damage stimulus|nuclear body|methylated histone binding|site of double-strand break|telomeric DNA binding|histone binding|positive regulation of isotype switching|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of DNA-binding transcription factor activity|protein homooligomerization|ubiquitin modification-dependent histone binding|cellular response to X-ray|DNA repair complex|negative regulation of double-strand break repair via homologous recombination" hsa04621 NOD-like receptor signaling pathway TP53BP2 3095.693254 3553.013409 2638.373099 0.742573358 -0.429394539 0.069988216 1 38.2756955 27.9468995 7159 tumor protein p53 binding protein 2 "GO:0002039,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0007049,GO:0007165,GO:0017124,GO:0030054,GO:0042802,GO:0042981,GO:0045786,GO:0048471,GO:0051059,GO:0072332,GO:1900119,GO:1900740,GO:1901216,GO:1901796" p53 binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|cell cycle|signal transduction|SH3 domain binding|cell junction|identical protein binding|regulation of apoptotic process|negative regulation of cell cycle|perinuclear region of cytoplasm|NF-kappaB binding|intrinsic apoptotic signaling pathway by p53 class mediator|positive regulation of execution phase of apoptosis|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of neuron death|regulation of signal transduction by p53 class mediator hsa04390 Hippo signaling pathway TP53I13 651.5707331 628.4099851 674.7314811 1.073712221 0.102607371 0.696279074 1 17.08460822 18.03699144 90313 tumor protein p53 inducible protein 13 "GO:0003674,GO:0005515,GO:0005737,GO:0005886,GO:0009411,GO:0014070,GO:0016021,GO:0042493,GO:0045786" molecular_function|protein binding|cytoplasm|plasma membrane|response to UV|response to organic cyclic compound|integral component of membrane|response to drug|negative regulation of cell cycle TP53I3 203.2782255 214.3252598 192.2311912 0.896913371 -0.156959447 0.672868639 1 9.085103418 8.012195768 9540 tumor protein p53 inducible protein 3 "GO:0003960,GO:0005829,GO:0006739,GO:0042803,GO:0042981,GO:0048038,GO:0055114,GO:0070402" NADPH:quinone reductase activity|cytosol|NADP metabolic process|protein homodimerization activity|regulation of apoptotic process|quinone binding|oxidation-reduction process|NADPH binding hsa04115 p53 signaling pathway TP53INP1 417.0203405 400.5593448 433.4813362 1.082190047 0.113953878 0.696221586 1 3.731386985 3.970498226 94241 tumor protein p53 inducible nuclear protein 1 "GO:0000045,GO:0005515,GO:0005634,GO:0005654,GO:0005776,GO:0005829,GO:0006915,GO:0007050,GO:0008285,GO:0009408,GO:0010508,GO:0010629,GO:0016209,GO:0016605,GO:0030336,GO:0031410,GO:0034644,GO:0042981,GO:0043065,GO:0045893,GO:0048102,GO:0048147,GO:0071361,GO:0071447,GO:0072703,GO:0098869,GO:1901796,GO:1904761" "autophagosome assembly|protein binding|nucleus|nucleoplasm|autophagosome|cytosol|apoptotic process|cell cycle arrest|negative regulation of cell population proliferation|response to heat|positive regulation of autophagy|negative regulation of gene expression|antioxidant activity|PML body|negative regulation of cell migration|cytoplasmic vesicle|cellular response to UV|regulation of apoptotic process|positive regulation of apoptotic process|positive regulation of transcription, DNA-templated|autophagic cell death|negative regulation of fibroblast proliferation|cellular response to ethanol|cellular response to hydroperoxide|cellular response to methyl methanesulfonate|cellular oxidant detoxification|regulation of signal transduction by p53 class mediator|negative regulation of myofibroblast differentiation" TP53INP2 987.8394964 965.5040831 1010.17491 1.046266844 0.065250849 0.794368428 1 12.29765594 12.65132405 58476 tumor protein p53 inducible nuclear protein 2 "GO:0000045,GO:0001649,GO:0001894,GO:0005515,GO:0005634,GO:0005776,GO:0005829,GO:0006511,GO:0010508,GO:0016605,GO:0031410,GO:0043130,GO:0045893,GO:1903828" "autophagosome assembly|osteoblast differentiation|tissue homeostasis|protein binding|nucleus|autophagosome|cytosol|ubiquitin-dependent protein catabolic process|positive regulation of autophagy|PML body|cytoplasmic vesicle|ubiquitin binding|positive regulation of transcription, DNA-templated|negative regulation of cellular protein localization" hsa04140 Autophagy - animal TP53RK 447.2866923 425.529278 469.0441065 1.102260481 0.140465195 0.621626218 1 7.141419961 7.739982677 112858 TP53 regulating kinase "GO:0000408,GO:0002039,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006468,GO:0008033,GO:0016787,GO:0070525,GO:0106310,GO:0106311,GO:1901796" EKC/KEOPS complex|p53 binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|protein phosphorylation|tRNA processing|hydrolase activity|tRNA threonylcarbamoyladenosine metabolic process|protein serine kinase activity|protein threonine kinase activity|regulation of signal transduction by p53 class mediator TP73 338.8402299 316.2858203 361.3946395 1.142620428 0.192346228 0.530265318 1 3.029903594 3.404097363 7161 tumor protein p73 "GO:0000187,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001822,GO:0002039,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005794,GO:0005829,GO:0006298,GO:0006357,GO:0006974,GO:0007050,GO:0007346,GO:0008134,GO:0008630,GO:0010243,GO:0010468,GO:0016032,GO:0019901,GO:0030054,GO:0042493,GO:0042771,GO:0042802,GO:0042981,GO:0043065,GO:0043231,GO:0045665,GO:0045893,GO:0045944,GO:0046872,GO:0048714,GO:0051262,GO:0060044,GO:0071158,GO:0097371,GO:1900740,GO:1901796,GO:1902036" "activation of MAPK activity|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|kidney development|p53 binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|mitochondrion|Golgi apparatus|cytosol|mismatch repair|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|cell cycle arrest|regulation of mitotic cell cycle|transcription factor binding|intrinsic apoptotic signaling pathway in response to DNA damage|response to organonitrogen compound|regulation of gene expression|viral process|protein kinase binding|cell junction|response to drug|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|intracellular membrane-bounded organelle|negative regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of oligodendrocyte differentiation|protein tetramerization|negative regulation of cardiac muscle cell proliferation|positive regulation of cell cycle arrest|MDM2/MDM4 family protein binding|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|regulation of signal transduction by p53 class mediator|regulation of hematopoietic stem cell differentiation" "hsa04115,hsa04390,hsa04722,hsa05162" p53 signaling pathway|Hippo signaling pathway|Neurotrophin signaling pathway|Measles P53 TPBG 1382.980348 1498.195991 1267.764706 0.846194165 -0.240939357 0.315048014 1 21.58638404 17.96061089 7162 trophoblast glycoprotein "GO:0005783,GO:0005887,GO:0007155,GO:0008285,GO:0008355,GO:0009986,GO:0030425,GO:0043679,GO:0050921,GO:0051897,GO:0051932,GO:0051965,GO:0060326,GO:0070374,GO:0072659,GO:0090497,GO:0140059" "endoplasmic reticulum|integral component of plasma membrane|cell adhesion|negative regulation of cell population proliferation|olfactory learning|cell surface|dendrite|axon terminus|positive regulation of chemotaxis|positive regulation of protein kinase B signaling|synaptic transmission, GABAergic|positive regulation of synapse assembly|cell chemotaxis|positive regulation of ERK1 and ERK2 cascade|protein localization to plasma membrane|mesenchymal cell migration|dendrite arborization" TPCN1 3042.091203 3596.710792 2487.471614 0.691596227 -0.531998096 0.024852193 0.86041596 30.58474259 20.79833761 53373 two pore segment channel 1 "GO:0005245,GO:0005248,GO:0005515,GO:0005764,GO:0005765,GO:0005768,GO:0010008,GO:0010508,GO:0015280,GO:0016021,GO:0034220,GO:0034765,GO:0035725,GO:0042802,GO:0042803,GO:0051209,GO:0072345,GO:0080025" "voltage-gated calcium channel activity|voltage-gated sodium channel activity|protein binding|lysosome|lysosomal membrane|endosome|endosome membrane|positive regulation of autophagy|ligand-gated sodium channel activity|integral component of membrane|ion transmembrane transport|regulation of ion transmembrane transport|sodium ion transmembrane transport|identical protein binding|protein homodimerization activity|release of sequestered calcium ion into cytosol|NAADP-sensitive calcium-release channel activity|phosphatidylinositol-3,5-bisphosphate binding" hsa04020 Calcium signaling pathway TPCN2 255.9185062 271.5480234 240.288989 0.884885797 -0.176436822 0.60190114 1 2.916485998 2.537571562 219931 two pore segment channel 2 "GO:0005245,GO:0005515,GO:0005764,GO:0005765,GO:0006874,GO:0006939,GO:0007040,GO:0010008,GO:0010506,GO:0016021,GO:0019065,GO:0019722,GO:0019901,GO:0034220,GO:0034765,GO:0042802,GO:0051209,GO:0072345" voltage-gated calcium channel activity|protein binding|lysosome|lysosomal membrane|cellular calcium ion homeostasis|smooth muscle contraction|lysosome organization|endosome membrane|regulation of autophagy|integral component of membrane|receptor-mediated endocytosis of virus by host cell|calcium-mediated signaling|protein kinase binding|ion transmembrane transport|regulation of ion transmembrane transport|identical protein binding|release of sequestered calcium ion into cytosol|NAADP-sensitive calcium-release channel activity "hsa04020,hsa04972" Calcium signaling pathway|Pancreatic secretion TPD52 2178.24071 1836.330503 2520.150917 1.372384172 0.456684392 0.053585111 1 12.07510891 16.29438358 7163 tumor protein D52 "GO:0005509,GO:0005515,GO:0005737,GO:0005783,GO:0009653,GO:0030183,GO:0042803,GO:0046903,GO:0048471" calcium ion binding|protein binding|cytoplasm|endoplasmic reticulum|anatomical structure morphogenesis|B cell differentiation|protein homodimerization activity|secretion|perinuclear region of cytoplasm TPD52L1 311.4422547 328.7707869 294.1137225 0.894585937 -0.160708015 0.611143155 1 9.215279749 8.105909844 7164 TPD52 like 1 "GO:0000086,GO:0005515,GO:0005737,GO:0042802,GO:0042803,GO:0043406,GO:0046330,GO:0048471,GO:2001235" G2/M transition of mitotic cell cycle|protein binding|cytoplasm|identical protein binding|protein homodimerization activity|positive regulation of MAP kinase activity|positive regulation of JNK cascade|perinuclear region of cytoplasm|positive regulation of apoptotic signaling pathway TPD52L2 7724.235915 7290.180076 8158.291754 1.119079593 0.16231265 0.509578716 1 136.3221836 150.0025662 7165 TPD52 like 2 "GO:0003723,GO:0005515,GO:0005975" RNA binding|protein binding|carbohydrate metabolic process TPGS1 83.43186981 70.74814402 96.1155956 1.358559958 0.442078239 0.381198428 1 3.389316353 4.527537914 91978 tubulin polyglutamylase complex subunit 1 "GO:0005737,GO:0005813,GO:0005874,GO:0007268,GO:0007275,GO:0007288,GO:0008017,GO:0018095,GO:0018215,GO:0030424,GO:0030425,GO:0030534,GO:0031514,GO:0045202,GO:0051648,GO:0070740" cytoplasm|centrosome|microtubule|chemical synaptic transmission|multicellular organism development|sperm axoneme assembly|microtubule binding|protein polyglutamylation|protein phosphopantetheinylation|axon|dendrite|adult behavior|motile cilium|synapse|vesicle localization|tubulin-glutamic acid ligase activity TPGS2 3447.279418 3345.971047 3548.58779 1.060555438 0.084820037 0.721502238 1 17.1948315 17.93091609 25941 tubulin polyglutamylase complex subunit 2 "GO:0005515,GO:0005737,GO:0005874,GO:0018095" protein binding|cytoplasm|microtubule|protein polyglutamylation TPH1 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.034516148 0.010451051 7166 tryptophan hydroxylase 1 "GO:0004510,GO:0005506,GO:0005515,GO:0005829,GO:0007623,GO:0009072,GO:0030279,GO:0035902,GO:0042427,GO:0043005,GO:0045600,GO:0046219,GO:0046849,GO:0055114,GO:0060749" tryptophan 5-monooxygenase activity|iron ion binding|protein binding|cytosol|circadian rhythm|aromatic amino acid family metabolic process|negative regulation of ossification|response to immobilization stress|serotonin biosynthetic process|neuron projection|positive regulation of fat cell differentiation|indolalkylamine biosynthetic process|bone remodeling|oxidation-reduction process|mammary gland alveolus development "hsa00380,hsa00790,hsa04726" Tryptophan metabolism|Folate biosynthesis|Serotonergic synapse TPI1 17664.97857 14279.68054 21050.27659 1.474141983 0.559875486 0.03741142 0.976326461 408.1844164 591.652786 7167 triosephosphate isomerase 1 "GO:0004807,GO:0005515,GO:0005615,GO:0005634,GO:0005829,GO:0006094,GO:0006096,GO:0007275,GO:0008929,GO:0019242,GO:0019563,GO:0031625,GO:0042803,GO:0046166,GO:0061621,GO:0070062" triose-phosphate isomerase activity|protein binding|extracellular space|nucleus|cytosol|gluconeogenesis|glycolytic process|multicellular organism development|methylglyoxal synthase activity|methylglyoxal biosynthetic process|glycerol catabolic process|ubiquitin protein ligase binding|protein homodimerization activity|glyceraldehyde-3-phosphate biosynthetic process|canonical glycolysis|extracellular exosome "hsa00010,hsa00051,hsa00562" Glycolysis / Gluconeogenesis|Fructose and mannose metabolism|Inositol phosphate metabolism TPK1 141.4427966 117.5667687 165.3188244 1.40616967 0.491770682 0.236971621 1 0.495602083 0.685238929 27010 thiamin pyrophosphokinase 1 "GO:0004788,GO:0005515,GO:0005524,GO:0005829,GO:0006772,GO:0009229,GO:0016301,GO:0016310,GO:0030975,GO:0042723,GO:0042802" thiamine diphosphokinase activity|protein binding|ATP binding|cytosol|thiamine metabolic process|thiamine diphosphate biosynthetic process|kinase activity|phosphorylation|thiamine binding|thiamine-containing compound metabolic process|identical protein binding hsa00730 Thiamine metabolism TPM1 2198.432588 2215.041156 2181.82402 0.985003829 -0.021798762 0.92851705 1 29.80652431 28.86824843 7168 tropomyosin 1 "GO:0001725,GO:0003065,GO:0003779,GO:0005200,GO:0005515,GO:0005829,GO:0005856,GO:0005862,GO:0005884,GO:0006936,GO:0006937,GO:0007010,GO:0007015,GO:0008016,GO:0008092,GO:0008307,GO:0008360,GO:0015629,GO:0030017,GO:0030049,GO:0030336,GO:0031529,GO:0032059,GO:0032587,GO:0032781,GO:0034614,GO:0042060,GO:0042802,GO:0042803,GO:0045214,GO:0045785,GO:0046982,GO:0051015,GO:0051496,GO:0055010,GO:0060048,GO:1904706,GO:1904753" stress fiber|positive regulation of heart rate by epinephrine|actin binding|structural constituent of cytoskeleton|protein binding|cytosol|cytoskeleton|muscle thin filament tropomyosin|actin filament|muscle contraction|regulation of muscle contraction|cytoskeleton organization|actin filament organization|regulation of heart contraction|cytoskeletal protein binding|structural constituent of muscle|regulation of cell shape|actin cytoskeleton|sarcomere|muscle filament sliding|negative regulation of cell migration|ruffle organization|bleb|ruffle membrane|positive regulation of ATPase activity|cellular response to reactive oxygen species|wound healing|identical protein binding|protein homodimerization activity|sarcomere organization|positive regulation of cell adhesion|protein heterodimerization activity|actin filament binding|positive regulation of stress fiber assembly|ventricular cardiac muscle tissue morphogenesis|cardiac muscle contraction|negative regulation of vascular associated smooth muscle cell proliferation|negative regulation of vascular associated smooth muscle cell migration "hsa04260,hsa04261,hsa05206,hsa05410,hsa05414" Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|MicroRNAs in cancer|Hypertrophic cardiomyopathy|Dilated cardiomyopathy TPM2 4619.607981 4045.129176 5194.086786 1.284034838 0.360684346 0.131914248 1 117.0087314 147.7291696 7169 tropomyosin 2 "GO:0003779,GO:0005829,GO:0005862,GO:0005884,GO:0006936,GO:0007015,GO:0008307,GO:0015629,GO:0030049,GO:0042802,GO:0042803,GO:0043462,GO:0046982,GO:0051015" actin binding|cytosol|muscle thin filament tropomyosin|actin filament|muscle contraction|actin filament organization|structural constituent of muscle|actin cytoskeleton|muscle filament sliding|identical protein binding|protein homodimerization activity|regulation of ATPase activity|protein heterodimerization activity|actin filament binding "hsa04260,hsa04261,hsa05410,hsa05414" Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Hypertrophic cardiomyopathy|Dilated cardiomyopathy TPM3 12099.97947 11064.80164 13135.15729 1.187111863 0.247455889 0.334004044 1 59.79223647 69.79231785 7170 tropomyosin 3 "GO:0001725,GO:0003674,GO:0005515,GO:0005829,GO:0005856,GO:0005862,GO:0005884,GO:0006936,GO:0007015,GO:0015629,GO:0030049,GO:0051015,GO:0070062" stress fiber|molecular_function|protein binding|cytosol|cytoskeleton|muscle thin filament tropomyosin|actin filament|muscle contraction|actin filament organization|actin cytoskeleton|muscle filament sliding|actin filament binding|extracellular exosome "hsa04260,hsa04261,hsa05200,hsa05216,hsa05410,hsa05414" Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Pathways in cancer|Thyroid cancer|Hypertrophic cardiomyopathy|Dilated cardiomyopathy TPM4 17821.26222 15632.21859 20010.30585 1.280068196 0.356220672 0.185201985 1 125.1331596 157.4985996 7171 tropomyosin 4 "GO:0001649,GO:0001725,GO:0005509,GO:0005515,GO:0005829,GO:0005856,GO:0005862,GO:0005884,GO:0005925,GO:0006936,GO:0007015,GO:0008307,GO:0016020,GO:0030049,GO:0042802,GO:0042803,GO:0046982,GO:0051015,GO:0070062" osteoblast differentiation|stress fiber|calcium ion binding|protein binding|cytosol|cytoskeleton|muscle thin filament tropomyosin|actin filament|focal adhesion|muscle contraction|actin filament organization|structural constituent of muscle|membrane|muscle filament sliding|identical protein binding|protein homodimerization activity|protein heterodimerization activity|actin filament binding|extracellular exosome "hsa04260,hsa04261,hsa05410,hsa05414" Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Hypertrophic cardiomyopathy|Dilated cardiomyopathy TPMT 511.6885574 513.964458 509.4126567 0.991143743 -0.012833792 0.970337981 1 7.698382963 7.502522973 7172 thiopurine S-methyltransferase "GO:0005515,GO:0005829,GO:0006139,GO:0008119,GO:0017144,GO:0032259,GO:1904047" protein binding|cytosol|nucleobase-containing compound metabolic process|thiopurine S-methyltransferase activity|drug metabolic process|methylation|S-adenosyl-L-methionine binding hsa00983 Drug metabolism - other enzymes TPP1 6197.414527 7352.604909 5042.224145 0.685773846 -0.544195211 0.025177919 0.86292743 112.3697052 75.7707067 1200 tripeptidyl peptidase 1 "GO:0004175,GO:0004252,GO:0005515,GO:0005764,GO:0005794,GO:0006508,GO:0006629,GO:0007040,GO:0007399,GO:0007417,GO:0008233,GO:0008236,GO:0008240,GO:0030163,GO:0030855,GO:0035727,GO:0036498,GO:0042277,GO:0042470,GO:0043171,GO:0043202,GO:0045121,GO:0045453,GO:0046872,GO:0050885,GO:0055037,GO:0070062,GO:0070198,GO:0120146,GO:1905146" "endopeptidase activity|serine-type endopeptidase activity|protein binding|lysosome|Golgi apparatus|proteolysis|lipid metabolic process|lysosome organization|nervous system development|central nervous system development|peptidase activity|serine-type peptidase activity|tripeptidyl-peptidase activity|protein catabolic process|epithelial cell differentiation|lysophosphatidic acid binding|IRE1-mediated unfolded protein response|peptide binding|melanosome|peptide catabolic process|lysosomal lumen|membrane raft|bone resorption|metal ion binding|neuromuscular process controlling balance|recycling endosome|extracellular exosome|protein localization to chromosome, telomeric region|sulfatide binding|lysosomal protein catabolic process" hsa04142 Lysosome TPP2 1948.652155 2016.322105 1880.982206 0.932877838 -0.100239925 0.673216721 1 19.17793707 17.59129629 7174 tripeptidyl peptidase 2 "GO:0000209,GO:0004175,GO:0004177,GO:0004252,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006508,GO:0008240,GO:0016604,GO:0042802" protein polyubiquitination|endopeptidase activity|aminopeptidase activity|serine-type endopeptidase activity|protein binding|nucleoplasm|cytoplasm|cytosol|proteolysis|tripeptidyl-peptidase activity|nuclear body|identical protein binding TPPP 27.46717225 14.56579436 40.36855015 2.771462315 1.470647391 0.053957157 1 0.090822488 0.247499058 11076 tubulin polymerization promoting protein "GO:0000287,GO:0001578,GO:0003924,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005874,GO:0008017,GO:0014003,GO:0015631,GO:0030953,GO:0031334,GO:0031643,GO:0032273,GO:0032288,GO:0042803,GO:0046785,GO:0048471,GO:0048709,GO:0051301,GO:0051418,GO:0070507,GO:0072686,GO:0097427,GO:0150051,GO:1904428" magnesium ion binding|microtubule bundle formation|GTPase activity|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|microtubule|microtubule binding|oligodendrocyte development|tubulin binding|astral microtubule organization|positive regulation of protein-containing complex assembly|positive regulation of myelination|positive regulation of protein polymerization|myelin assembly|protein homodimerization activity|microtubule polymerization|perinuclear region of cytoplasm|oligodendrocyte differentiation|cell division|microtubule nucleation by microtubule organizing center|regulation of microtubule cytoskeleton organization|mitotic spindle|microtubule bundle|postsynaptic Golgi apparatus|negative regulation of tubulin deacetylation TPPP3 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.025261591 0.068839999 51673 tubulin polymerization promoting protein family member 3 "GO:0001578,GO:0005874,GO:0007566,GO:0015631,GO:0032273,GO:0046697,GO:0046785,GO:0048471,GO:0097427" microtubule bundle formation|microtubule|embryo implantation|tubulin binding|positive regulation of protein polymerization|decidualization|microtubule polymerization|perinuclear region of cytoplasm|microtubule bundle TPR 4442.571732 4898.268559 3986.874905 0.813935548 -0.297013536 0.213929965 1 27.12864159 21.71147071 7175 "translocated promoter region, nuclear basket protein" "GO:0000122,GO:0000776,GO:0003682,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005737,GO:0005868,GO:0006110,GO:0006404,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0006611,GO:0006999,GO:0007094,GO:0010793,GO:0010965,GO:0015631,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0019898,GO:0031072,GO:0031453,GO:0031647,GO:0031965,GO:0031990,GO:0032880,GO:0034399,GO:0034605,GO:0035457,GO:0042306,GO:0042307,GO:0042405,GO:0042803,GO:0043495,GO:0043578,GO:0043657,GO:0044615,GO:0045947,GO:0046825,GO:0046827,GO:0046832,GO:0051019,GO:0051292,GO:0051301,GO:0060964,GO:0070840,GO:0070849,GO:0072686,GO:0075733,GO:0090267,GO:0090316,GO:1900034,GO:1901673" negative regulation of transcription by RNA polymerase II|kinetochore|chromatin binding|RNA binding|mRNA binding|protein binding|nucleus|nuclear envelope|nuclear pore|nucleoplasm|cytoplasm|cytoplasmic dynein complex|regulation of glycolytic process|RNA import into nucleus|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|protein export from nucleus|nuclear pore organization|mitotic spindle assembly checkpoint|regulation of mRNA export from nucleus|regulation of mitotic sister chromatid separation|tubulin binding|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|extrinsic component of membrane|heat shock protein binding|positive regulation of heterochromatin assembly|regulation of protein stability|nuclear membrane|mRNA export from nucleus in response to heat stress|regulation of protein localization|nuclear periphery|cellular response to heat|cellular response to interferon-alpha|regulation of protein import into nucleus|positive regulation of protein import into nucleus|nuclear inclusion body|protein homodimerization activity|protein-membrane adaptor activity|nuclear matrix organization|host cell|nuclear pore nuclear basket|negative regulation of translational initiation|regulation of protein export from nucleus|positive regulation of protein export from nucleus|negative regulation of RNA export from nucleus|mitogen-activated protein kinase binding|nuclear pore complex assembly|cell division|regulation of gene silencing by miRNA|dynein complex binding|response to epidermal growth factor|mitotic spindle|intracellular transport of virus|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of intracellular protein transport|regulation of cellular response to heat|regulation of mitotic spindle assembly "hsa03013,hsa05014,hsa05200,hsa05216" RNA transport|Amyotrophic lateral sclerosis|Pathways in cancer|Thyroid cancer TPRA1 845.762022 932.2108388 759.3132052 0.814529475 -0.295961189 0.236600525 1 9.64902621 7.727899567 131601 transmembrane protein adipocyte associated 1 "GO:0004930,GO:0005515,GO:0006629,GO:0007186,GO:0007568,GO:0016021,GO:0040016,GO:1901991" G protein-coupled receptor activity|protein binding|lipid metabolic process|G protein-coupled receptor signaling pathway|aging|integral component of membrane|embryonic cleavage|negative regulation of mitotic cell cycle phase transition TPRG1L 902.1141772 821.9269673 982.301387 1.195120036 0.257155528 0.300843138 1 18.26935927 21.4687136 127262 tumor protein p63 regulated 1 like "GO:0003674,GO:0005737,GO:0008021,GO:0008150,GO:0030672,GO:0042802,GO:0044305,GO:0048786,GO:0051966,GO:0070062" "molecular_function|cytoplasm|synaptic vesicle|biological_process|synaptic vesicle membrane|identical protein binding|calyx of Held|presynaptic active zone|regulation of synaptic transmission, glutamatergic|extracellular exosome" TPRKB 535.3557652 517.0856997 553.6258307 1.070665522 0.09850785 0.719512975 1 28.42009622 29.91923881 51002 TP53RK binding protein "GO:0000408,GO:0000722,GO:0002949,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0019901" EKC/KEOPS complex|telomere maintenance via recombination|tRNA threonylcarbamoyladenosine modification|protein binding|nucleus|cytoplasm|cytosol|protein kinase binding TPRN 292.8387221 281.9521622 303.7252821 1.077222745 0.107316597 0.743416103 1 5.658995371 5.993990247 286262 taperin "GO:0003674,GO:0005515,GO:0007605,GO:0019902,GO:0032420,GO:0060088,GO:0120044,GO:0120045" molecular_function|protein binding|sensory perception of sound|phosphatase binding|stereocilium|auditory receptor cell stereocilium organization|stereocilium base|stereocilium maintenance TPST1 319.5875426 290.2754733 348.899612 1.201960359 0.265389316 0.392384213 1 4.803556125 5.677069261 8460 tyrosylprotein sulfotransferase 1 "GO:0000139,GO:0005794,GO:0006478,GO:0006954,GO:0008146,GO:0008476,GO:0016020,GO:0018215,GO:0030173,GO:0042803,GO:0050427" Golgi membrane|Golgi apparatus|peptidyl-tyrosine sulfation|inflammatory response|sulfotransferase activity|protein-tyrosine sulfotransferase activity|membrane|protein phosphopantetheinylation|integral component of Golgi membrane|protein homodimerization activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process TPST2 456.7894258 397.4381032 516.1407484 1.298669514 0.37703434 0.177330742 1 3.566595108 4.554320961 8459 tyrosylprotein sulfotransferase 2 "GO:0000139,GO:0005783,GO:0005794,GO:0006478,GO:0008146,GO:0008476,GO:0016021,GO:0018215,GO:0042803,GO:0050427" Golgi membrane|endoplasmic reticulum|Golgi apparatus|peptidyl-tyrosine sulfation|sulfotransferase activity|protein-tyrosine sulfotransferase activity|integral component of membrane|protein phosphopantetheinylation|protein homodimerization activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process TPT1 43398.05544 40499.1508 46296.96009 1.143158787 0.19302581 0.541359716 1 458.5964871 515.4760134 7178 "tumor protein, translationally-controlled 1" "GO:0000922,GO:0003723,GO:0005509,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005771,GO:0005829,GO:0005881,GO:0006816,GO:0006874,GO:0009615,GO:0042981,GO:0043066,GO:0070062,GO:1902230" spindle pole|RNA binding|calcium ion binding|protein binding|extracellular space|nucleus|cytoplasm|multivesicular body|cytosol|cytoplasmic microtubule|calcium ion transport|cellular calcium ion homeostasis|response to virus|regulation of apoptotic process|negative regulation of apoptotic process|extracellular exosome|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage TPTE2 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.061036836 93492 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 "GO:0000139,GO:0004725,GO:0005634,GO:0005789,GO:0005829,GO:0005886,GO:0006470,GO:0006661,GO:0008138,GO:0008285,GO:0014065,GO:0016021,GO:0016311,GO:0016314,GO:0035335,GO:0042995,GO:0046856,GO:0048870,GO:0051896" "Golgi membrane|protein tyrosine phosphatase activity|nucleus|endoplasmic reticulum membrane|cytosol|plasma membrane|protein dephosphorylation|phosphatidylinositol biosynthetic process|protein tyrosine/serine/threonine phosphatase activity|negative regulation of cell population proliferation|phosphatidylinositol 3-kinase signaling|integral component of membrane|dephosphorylation|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|peptidyl-tyrosine dephosphorylation|cell projection|phosphatidylinositol dephosphorylation|cell motility|regulation of protein kinase B signaling" TPTEP2-CSNK1E 62.20718085 68.66731625 55.74704545 0.811842496 -0.300728234 0.602518446 1 1.081017246 0.862930029 102800317 TPTEP2-CSNK1E readthrough "hsa04068,hsa04310,hsa04340,hsa04390,hsa04392,hsa04710,hsa05010,hsa05022" FoxO signaling pathway|Wnt signaling pathway|Hedgehog signaling pathway|Hippo signaling pathway|Hippo signaling pathway - multiple species|Circadian rhythm|Alzheimer disease|Pathways of neurodegeneration - multiple diseases TPX2 9923.66253 10616.38326 9230.941801 0.869499676 -0.201742605 0.421815611 1 161.1882966 137.8078981 22974 TPX2 microtubule nucleation factor "GO:0000278,GO:0000922,GO:0005515,GO:0005634,GO:0005654,GO:0005819,GO:0005829,GO:0005880,GO:0006915,GO:0007020,GO:0007026,GO:0008017,GO:0010389,GO:0015630,GO:0019901,GO:0030295,GO:0032147,GO:0043203,GO:0045171,GO:0051301,GO:0060236,GO:0061676,GO:0072686,GO:0090307,GO:1901796" mitotic cell cycle|spindle pole|protein binding|nucleus|nucleoplasm|spindle|cytosol|nuclear microtubule|apoptotic process|microtubule nucleation|negative regulation of microtubule depolymerization|microtubule binding|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|protein kinase binding|protein kinase activator activity|activation of protein kinase activity|axon hillock|intercellular bridge|cell division|regulation of mitotic spindle organization|importin-alpha family protein binding|mitotic spindle|mitotic spindle assembly|regulation of signal transduction by p53 class mediator TRA2A 663.4310827 712.6835096 614.1786559 0.861783172 -0.214603167 0.407545412 1 17.39122499 14.73667011 29896 transformer 2 alpha homolog "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005730,GO:0043231,GO:0048026" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|nucleolus|intracellular membrane-bounded organelle|positive regulation of mRNA splicing, via spliceosome" hsa03040 Spliceosome TRA2B 2227.594359 2198.394534 2256.794185 1.026564682 0.037824531 0.874669623 1 21.56299868 21.76540002 6434 transformer 2 beta homolog "GO:0000302,GO:0000375,GO:0000381,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005637,GO:0005654,GO:0005681,GO:0019904,GO:0021796,GO:0032991,GO:0036002,GO:0042802,GO:0043484,GO:0048026,GO:0048471,GO:0071333,GO:1990403" "response to reactive oxygen species|RNA splicing, via transesterification reactions|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nuclear inner membrane|nucleoplasm|spliceosomal complex|protein domain specific binding|cerebral cortex regionalization|protein-containing complex|pre-mRNA binding|identical protein binding|regulation of RNA splicing|positive regulation of mRNA splicing, via spliceosome|perinuclear region of cytoplasm|cellular response to glucose stimulus|embryonic brain development" hsa03040 Spliceosome TRABD 1024.759712 975.9082219 1073.611203 1.100114928 0.137654248 0.576606825 1 25.17275407 27.22951896 80305 TraB domain containing TRABD2A 503.642649 504.6007331 502.684565 0.996202605 -0.005488911 0.992252865 1 6.311135155 6.181962021 129293 TraB domain containing 2A "GO:0004175,GO:0004222,GO:0005887,GO:0006508,GO:0016020,GO:0016055,GO:0017147,GO:0030178,GO:0031301,GO:0031334,GO:0046872,GO:0060322,GO:1904808" endopeptidase activity|metalloendopeptidase activity|integral component of plasma membrane|proteolysis|membrane|Wnt signaling pathway|Wnt-protein binding|negative regulation of Wnt signaling pathway|integral component of organelle membrane|positive regulation of protein-containing complex assembly|metal ion binding|head development|positive regulation of protein oxidation TRADD 475.6854523 414.0847253 537.2861794 1.297527164 0.375764742 0.17445798 1 13.52444353 17.25468528 8717 TNFRSF1A associated via death domain "GO:0002947,GO:0005068,GO:0005164,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006915,GO:0006919,GO:0007165,GO:0007169,GO:0007249,GO:0008625,GO:0010803,GO:0019900,GO:0030335,GO:0031264,GO:0033209,GO:0042802,GO:0043065,GO:0043123,GO:0043235,GO:0044877,GO:0045121,GO:0050729,GO:0051092,GO:0051798,GO:0070513,GO:0071356,GO:0071550,GO:0097191,GO:1901224,GO:1902041,GO:1902042" tumor necrosis factor receptor superfamily complex|transmembrane receptor protein tyrosine kinase adaptor activity|tumor necrosis factor receptor binding|protein binding|nucleus|cytoplasm|cytosol|cytoskeleton|plasma membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|I-kappaB kinase/NF-kappaB signaling|extrinsic apoptotic signaling pathway via death domain receptors|regulation of tumor necrosis factor-mediated signaling pathway|kinase binding|positive regulation of cell migration|death-inducing signaling complex|tumor necrosis factor-mediated signaling pathway|identical protein binding|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|receptor complex|protein-containing complex binding|membrane raft|positive regulation of inflammatory response|positive regulation of NF-kappaB transcription factor activity|positive regulation of hair follicle development|death domain binding|cellular response to tumor necrosis factor|death-inducing signaling complex assembly|extrinsic apoptotic signaling pathway|positive regulation of NIK/NF-kappaB signaling|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors "hsa04010,hsa04064,hsa04071,hsa04210,hsa04217,hsa04622,hsa04657,hsa04668,hsa04920,hsa05130,hsa05131,hsa05132,hsa05152,hsa05160,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05203" MAPK signaling pathway|NF-kappa B signaling pathway|Sphingolipid signaling pathway|Apoptosis|Necroptosis|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Adipocytokine signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Tuberculosis|Hepatitis C|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis TRAF1 275.5228237 319.407062 231.6385854 0.725214352 -0.463520619 0.152896886 1 3.800706322 2.710203375 7185 TNF receptor associated factor 1 "GO:0005164,GO:0005515,GO:0005737,GO:0005829,GO:0006915,GO:0008270,GO:0009898,GO:0010803,GO:0031625,GO:0031996,GO:0033209,GO:0042802,GO:0043122,GO:0046330,GO:0051092,GO:0065003,GO:0070534,GO:0098802,GO:2001236" tumor necrosis factor receptor binding|protein binding|cytoplasm|cytosol|apoptotic process|zinc ion binding|cytoplasmic side of plasma membrane|regulation of tumor necrosis factor-mediated signaling pathway|ubiquitin protein ligase binding|thioesterase binding|tumor necrosis factor-mediated signaling pathway|identical protein binding|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein-containing complex assembly|protein K63-linked ubiquitination|plasma membrane signaling receptor complex|regulation of extrinsic apoptotic signaling pathway "hsa04064,hsa04210,hsa04668,hsa05200,hsa05202,hsa05203,hsa05222" NF-kappa B signaling pathway|Apoptosis|TNF signaling pathway|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Small cell lung cancer TRAF2 694.3711269 755.3404788 633.401775 0.838564585 -0.254006193 0.322762801 1 11.94403944 9.848246811 7186 TNF receptor associated factor 2 "GO:0000151,GO:0002637,GO:0002726,GO:0002947,GO:0004842,GO:0005164,GO:0005174,GO:0005515,GO:0005654,GO:0005829,GO:0005938,GO:0006919,GO:0007165,GO:0007249,GO:0007250,GO:0008270,GO:0009898,GO:0010803,GO:0012506,GO:0016579,GO:0019899,GO:0019901,GO:0019903,GO:0030163,GO:0030674,GO:0031435,GO:0031625,GO:0031996,GO:0032743,GO:0033209,GO:0034351,GO:0034622,GO:0034976,GO:0035631,GO:0042802,GO:0042981,GO:0043120,GO:0043122,GO:0043123,GO:0043254,GO:0043507,GO:0044877,GO:0045121,GO:0046330,GO:0046625,GO:0051091,GO:0051092,GO:0051865,GO:0065003,GO:0070059,GO:0070534,GO:0071550,GO:0071732,GO:0097057,GO:0097300,GO:0098802,GO:1901215,GO:1902041,GO:1902042,GO:1903265,GO:1903721,GO:1990604,GO:2001238" ubiquitin ligase complex|regulation of immunoglobulin production|positive regulation of T cell cytokine production|tumor necrosis factor receptor superfamily complex|ubiquitin-protein transferase activity|tumor necrosis factor receptor binding|CD40 receptor binding|protein binding|nucleoplasm|cytosol|cell cortex|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|I-kappaB kinase/NF-kappaB signaling|activation of NF-kappaB-inducing kinase activity|zinc ion binding|cytoplasmic side of plasma membrane|regulation of tumor necrosis factor-mediated signaling pathway|vesicle membrane|protein deubiquitination|enzyme binding|protein kinase binding|protein phosphatase binding|protein catabolic process|protein-macromolecule adaptor activity|mitogen-activated protein kinase kinase kinase binding|ubiquitin protein ligase binding|thioesterase binding|positive regulation of interleukin-2 production|tumor necrosis factor-mediated signaling pathway|negative regulation of glial cell apoptotic process|cellular protein-containing complex assembly|response to endoplasmic reticulum stress|CD40 receptor complex|identical protein binding|regulation of apoptotic process|tumor necrosis factor binding|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|regulation of protein-containing complex assembly|positive regulation of JUN kinase activity|protein-containing complex binding|membrane raft|positive regulation of JNK cascade|sphingolipid binding|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|protein autoubiquitination|protein-containing complex assembly|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|protein K63-linked ubiquitination|death-inducing signaling complex assembly|cellular response to nitric oxide|TRAF2-GSTP1 complex|programmed necrotic cell death|plasma membrane signaling receptor complex|negative regulation of neuron death|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of I-kappaB phosphorylation|IRE1-TRAF2-ASK1 complex|positive regulation of extrinsic apoptotic signaling pathway "hsa04010,hsa04064,hsa04071,hsa04141,hsa04210,hsa04217,hsa04380,hsa04621,hsa04622,hsa04657,hsa04668,hsa04920,hsa04932,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022,hsa05130,hsa05131,hsa05132,hsa05135,hsa05160,hsa05163,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05203,hsa05222" MAPK signaling pathway|NF-kappa B signaling pathway|Sphingolipid signaling pathway|Protein processing in endoplasmic reticulum|Apoptosis|Necroptosis|Osteoclast differentiation|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Adipocytokine signaling pathway|Non-alcoholic fatty liver disease|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection|Hepatitis C|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Small cell lung cancer TRAF3 1429.481327 1684.430076 1174.532578 0.697287822 -0.52017381 0.029777154 0.891465488 8.371664864 5.739777968 7187 TNF receptor associated factor 3 "GO:0001817,GO:0002224,GO:0004842,GO:0005164,GO:0005515,GO:0005739,GO:0005768,GO:0005829,GO:0006915,GO:0007165,GO:0008063,GO:0008270,GO:0009898,GO:0016579,GO:0019901,GO:0019903,GO:0030162,GO:0031625,GO:0031996,GO:0032088,GO:0032648,GO:0033209,GO:0035631,GO:0035666,GO:0042802,GO:0042981,GO:0043122,GO:0045087,GO:0046330,GO:0050688,GO:0070534,GO:0098802" regulation of cytokine production|toll-like receptor signaling pathway|ubiquitin-protein transferase activity|tumor necrosis factor receptor binding|protein binding|mitochondrion|endosome|cytosol|apoptotic process|signal transduction|Toll signaling pathway|zinc ion binding|cytoplasmic side of plasma membrane|protein deubiquitination|protein kinase binding|protein phosphatase binding|regulation of proteolysis|ubiquitin protein ligase binding|thioesterase binding|negative regulation of NF-kappaB transcription factor activity|regulation of interferon-beta production|tumor necrosis factor-mediated signaling pathway|CD40 receptor complex|TRIF-dependent toll-like receptor signaling pathway|identical protein binding|regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of JNK cascade|regulation of defense response to virus|protein K63-linked ubiquitination|plasma membrane signaling receptor complex "hsa04064,hsa04620,hsa04621,hsa04622,hsa04657,hsa04668,hsa05160,hsa05161,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05171,hsa05200,hsa05203,hsa05222" NF-kappa B signaling pathway|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Small cell lung cancer TRAF3IP1 484.9001079 504.6007331 465.1994827 0.921915987 -0.11729281 0.674988679 1 5.855536792 5.307979522 26146 TRAF3 interacting protein 1 "GO:0001738,GO:0001822,GO:0001933,GO:0005515,GO:0005813,GO:0005929,GO:0005930,GO:0008017,GO:0030992,GO:0031333,GO:0032480,GO:0035735,GO:0035869,GO:0036064,GO:0042073,GO:0050687,GO:0060271,GO:0070507,GO:0097542,GO:0097546" morphogenesis of a polarized epithelium|kidney development|negative regulation of protein phosphorylation|protein binding|centrosome|cilium|axoneme|microtubule binding|intraciliary transport particle B|negative regulation of protein-containing complex assembly|negative regulation of type I interferon production|intraciliary transport involved in cilium assembly|ciliary transition zone|ciliary basal body|intraciliary transport|negative regulation of defense response to virus|cilium assembly|regulation of microtubule cytoskeleton organization|ciliary tip|ciliary base TRAF3IP2 599.6582507 653.3799183 545.936583 0.835557641 -0.259188739 0.325174789 1 5.803875729 4.768323352 10758 TRAF3 interacting protein 2 "GO:0001783,GO:0002230,GO:0005102,GO:0005515,GO:0005575,GO:0006954,GO:0006959,GO:0035556,GO:0043123,GO:0061630,GO:0070534,GO:0097400" B cell apoptotic process|positive regulation of defense response to virus by host|signaling receptor binding|protein binding|cellular_component|inflammatory response|humoral immune response|intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin protein ligase activity|protein K63-linked ubiquitination|interleukin-17-mediated signaling pathway "hsa04218,hsa04657" Cellular senescence|IL-17 signaling pathway TRAF4 1094.724724 1172.546446 1016.903001 0.867260316 -0.205462998 0.400322597 1 15.2849655 13.03422207 9618 TNF receptor associated factor 4 "GO:0001650,GO:0005164,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005923,GO:0006915,GO:0007250,GO:0007585,GO:0008270,GO:0019901,GO:0030323,GO:0031625,GO:0031996,GO:0033209,GO:0042802,GO:0042981,GO:0043122,GO:0045860,GO:0046330,GO:0048471,GO:0050699,GO:0070534,GO:0098802" fibrillar center|tumor necrosis factor receptor binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|plasma membrane|bicellular tight junction|apoptotic process|activation of NF-kappaB-inducing kinase activity|respiratory gaseous exchange by respiratory system|zinc ion binding|protein kinase binding|respiratory tube development|ubiquitin protein ligase binding|thioesterase binding|tumor necrosis factor-mediated signaling pathway|identical protein binding|regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of protein kinase activity|positive regulation of JNK cascade|perinuclear region of cytoplasm|WW domain binding|protein K63-linked ubiquitination|plasma membrane signaling receptor complex "hsa04657,hsa05200,hsa05222" IL-17 signaling pathway|Pathways in cancer|Small cell lung cancer TRAF5 672.6463527 702.2793708 643.0133346 0.915609032 -0.127196401 0.625008767 1 5.161024413 4.646406047 7188 TNF receptor associated factor 5 "GO:0004842,GO:0005164,GO:0005515,GO:0005813,GO:0005829,GO:0006915,GO:0007165,GO:0008270,GO:0008284,GO:0009898,GO:0031625,GO:0031996,GO:0033209,GO:0035631,GO:0042802,GO:0042981,GO:0043122,GO:0043123,GO:0046330,GO:0051091,GO:0051092,GO:0070534,GO:0098802" ubiquitin-protein transferase activity|tumor necrosis factor receptor binding|protein binding|centrosome|cytosol|apoptotic process|signal transduction|zinc ion binding|positive regulation of cell population proliferation|cytoplasmic side of plasma membrane|ubiquitin protein ligase binding|thioesterase binding|tumor necrosis factor-mediated signaling pathway|CD40 receptor complex|identical protein binding|regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of JNK cascade|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|protein K63-linked ubiquitination|plasma membrane signaling receptor complex "hsa04064,hsa04217,hsa04621,hsa04657,hsa04668,hsa05131,hsa05163,hsa05168,hsa05169,hsa05170,hsa05200,hsa05203,hsa05222" NF-kappa B signaling pathway|Necroptosis|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Shigellosis|Human cytomegalovirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Small cell lung cancer TRAF6 555.3469258 499.3986637 611.295188 1.224062523 0.29167725 0.275479188 1 2.795760917 3.36492051 7189 TNF receptor associated factor 6 "GO:0000122,GO:0000187,GO:0000209,GO:0001503,GO:0001701,GO:0001843,GO:0002223,GO:0002224,GO:0002637,GO:0002726,GO:0002755,GO:0004842,GO:0005164,GO:0005515,GO:0005634,GO:0005737,GO:0005811,GO:0005829,GO:0005886,GO:0005938,GO:0006974,GO:0007249,GO:0007250,GO:0007254,GO:0008270,GO:0009898,GO:0010008,GO:0016579,GO:0019886,GO:0019901,GO:0030316,GO:0031293,GO:0031398,GO:0031435,GO:0031624,GO:0031625,GO:0031666,GO:0031996,GO:0032147,GO:0032735,GO:0032743,GO:0032755,GO:0032991,GO:0033209,GO:0034162,GO:0035631,GO:0038095,GO:0042088,GO:0042102,GO:0042475,GO:0042802,GO:0042826,GO:0043011,GO:0043065,GO:0043066,GO:0043122,GO:0043123,GO:0043422,GO:0043507,GO:0045453,GO:0045672,GO:0045892,GO:0045944,GO:0046330,GO:0047485,GO:0048468,GO:0048471,GO:0048661,GO:0050852,GO:0051091,GO:0051092,GO:0051865,GO:0061630,GO:0070423,GO:0070498,GO:0070534,GO:0070555,GO:0071222,GO:0071345,GO:0098802,GO:1901224,GO:1904996,GO:2000679" "negative regulation of transcription by RNA polymerase II|activation of MAPK activity|protein polyubiquitination|ossification|in utero embryonic development|neural tube closure|stimulatory C-type lectin receptor signaling pathway|toll-like receptor signaling pathway|regulation of immunoglobulin production|positive regulation of T cell cytokine production|MyD88-dependent toll-like receptor signaling pathway|ubiquitin-protein transferase activity|tumor necrosis factor receptor binding|protein binding|nucleus|cytoplasm|lipid droplet|cytosol|plasma membrane|cell cortex|cellular response to DNA damage stimulus|I-kappaB kinase/NF-kappaB signaling|activation of NF-kappaB-inducing kinase activity|JNK cascade|zinc ion binding|cytoplasmic side of plasma membrane|endosome membrane|protein deubiquitination|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|osteoclast differentiation|membrane protein intracellular domain proteolysis|positive regulation of protein ubiquitination|mitogen-activated protein kinase kinase kinase binding|ubiquitin conjugating enzyme binding|ubiquitin protein ligase binding|positive regulation of lipopolysaccharide-mediated signaling pathway|thioesterase binding|activation of protein kinase activity|positive regulation of interleukin-12 production|positive regulation of interleukin-2 production|positive regulation of interleukin-6 production|protein-containing complex|tumor necrosis factor-mediated signaling pathway|toll-like receptor 9 signaling pathway|CD40 receptor complex|Fc-epsilon receptor signaling pathway|T-helper 1 type immune response|positive regulation of T cell proliferation|odontogenesis of dentin-containing tooth|identical protein binding|histone deacetylase binding|myeloid dendritic cell differentiation|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|protein kinase B binding|positive regulation of JUN kinase activity|bone resorption|positive regulation of osteoclast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|protein N-terminus binding|cell development|perinuclear region of cytoplasm|positive regulation of smooth muscle cell proliferation|T cell receptor signaling pathway|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|protein autoubiquitination|ubiquitin protein ligase activity|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|protein K63-linked ubiquitination|response to interleukin-1|cellular response to lipopolysaccharide|cellular response to cytokine stimulus|plasma membrane signaling receptor complex|positive regulation of NIK/NF-kappaB signaling|positive regulation of leukocyte adhesion to vascular endothelial cell|positive regulation of transcription regulatory region DNA binding" "hsa04010,hsa04064,hsa04120,hsa04140,hsa04144,hsa04380,hsa04620,hsa04621,hsa04622,hsa04657,hsa04722,hsa05130,hsa05131,hsa05132,hsa05133,hsa05135,hsa05140,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05168,hsa05169,hsa05170,hsa05171,hsa05200,hsa05222,hsa05235" MAPK signaling pathway|NF-kappa B signaling pathway|Ubiquitin mediated proteolysis|Autophagy - animal|Endocytosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|Neurotrophin signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Pertussis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer TRAF7 2506.530304 2594.792223 2418.268385 0.931969953 -0.101644653 0.668126672 1 37.33601832 34.21378249 84231 TNF receptor associated factor 7 "GO:0000027,GO:0000151,GO:0000185,GO:0004842,GO:0005515,GO:0005730,GO:0005886,GO:0006915,GO:0007219,GO:0008270,GO:0016567,GO:0031410,GO:0043231,GO:0043410,GO:0070372,GO:2001235" ribosomal large subunit assembly|ubiquitin ligase complex|activation of MAPKKK activity|ubiquitin-protein transferase activity|protein binding|nucleolus|plasma membrane|apoptotic process|Notch signaling pathway|zinc ion binding|protein ubiquitination|cytoplasmic vesicle|intracellular membrane-bounded organelle|positive regulation of MAPK cascade|regulation of ERK1 and ERK2 cascade|positive regulation of apoptotic signaling pathway TRAFD1 548.6628791 588.8742576 508.4515007 0.863429661 -0.211849441 0.430637866 1 11.93586662 10.13332798 10906 TRAF-type zinc finger domain containing 1 "GO:0005515,GO:0045824,GO:0046872" protein binding|negative regulation of innate immune response|metal ion binding TRAIP 399.4716987 419.2867947 379.6566026 0.905481898 -0.143242295 0.625545382 1 11.02837142 9.818888656 10293 TRAF interacting protein "GO:0004842,GO:0005515,GO:0005654,GO:0005730,GO:0006915,GO:0006974,GO:0007165,GO:0010804,GO:0016567,GO:0031297,GO:0032088,GO:0032688,GO:0042802,GO:0046872,GO:0048471,GO:0061630,GO:0090734,GO:0106300" ubiquitin-protein transferase activity|protein binding|nucleoplasm|nucleolus|apoptotic process|cellular response to DNA damage stimulus|signal transduction|negative regulation of tumor necrosis factor-mediated signaling pathway|protein ubiquitination|replication fork processing|negative regulation of NF-kappaB transcription factor activity|negative regulation of interferon-beta production|identical protein binding|metal ion binding|perinuclear region of cytoplasm|ubiquitin protein ligase activity|site of DNA damage|protein-DNA covalent cross-linking repair TRAK1 1324.56933 1251.617901 1397.52076 1.116571407 0.159075517 0.50922009 1 8.075994075 8.866529684 22906 trafficking kinesin protein 1 "GO:0005102,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005769,GO:0005938,GO:0006357,GO:0006493,GO:0006605,GO:0008333,GO:0017022,GO:0022008,GO:0030425,GO:0031410,GO:0031966,GO:0047496,GO:0048311,GO:0050811,GO:0098957,GO:1904115" signaling receptor binding|protein binding|nucleus|cytoplasm|mitochondrion|early endosome|cell cortex|regulation of transcription by RNA polymerase II|protein O-linked glycosylation|protein targeting|endosome to lysosome transport|myosin binding|neurogenesis|dendrite|cytoplasmic vesicle|mitochondrial membrane|vesicle transport along microtubule|mitochondrion distribution|GABA receptor binding|anterograde axonal transport of mitochondrion|axon cytoplasm TRAK2 1356.379369 1619.924415 1092.834322 0.674620564 -0.5678518 0.018077066 0.773499658 13.34141802 8.849785521 66008 trafficking kinesin protein 2 "GO:0005102,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005769,GO:0005886,GO:0006357,GO:0006493,GO:0006605,GO:0008333,GO:0017022,GO:0019894,GO:0019899,GO:0022008,GO:0030425,GO:0030911,GO:0031410,GO:0032839,GO:0043025,GO:0044295,GO:0047496,GO:0048311,GO:0048813,GO:0050771,GO:0050811,GO:0098957,GO:0098972,GO:1904115" signaling receptor binding|protein binding|nucleus|cytoplasm|mitochondrion|early endosome|plasma membrane|regulation of transcription by RNA polymerase II|protein O-linked glycosylation|protein targeting|endosome to lysosome transport|myosin binding|kinesin binding|enzyme binding|neurogenesis|dendrite|TPR domain binding|cytoplasmic vesicle|dendrite cytoplasm|neuronal cell body|axonal growth cone|vesicle transport along microtubule|mitochondrion distribution|dendrite morphogenesis|negative regulation of axonogenesis|GABA receptor binding|anterograde axonal transport of mitochondrion|anterograde dendritic transport of mitochondrion|axon cytoplasm hsa04727 GABAergic synapse TRAM1 5509.406498 5515.233992 5503.579004 0.997886765 -0.00305198 0.990749152 1 81.15188905 79.62529874 23471 translocation associated membrane protein 1 "GO:0005515,GO:0005783,GO:0006613,GO:0006616,GO:0016021,GO:0016032,GO:0030176,GO:0038023,GO:0045048" "protein binding|endoplasmic reticulum|cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane, translocation|integral component of membrane|viral process|integral component of endoplasmic reticulum membrane|signaling receptor activity|protein insertion into ER membrane" hsa04141 Protein processing in endoplasmic reticulum TRAM1L1 91.39348978 90.51600779 92.27097178 1.019388438 0.027703895 0.979844322 1 2.387875914 2.393440508 133022 translocation associated membrane protein 1 like 1 "GO:0005515,GO:0006616,GO:0030176,GO:0045048" "protein binding|SRP-dependent cotranslational protein targeting to membrane, translocation|integral component of endoplasmic reticulum membrane|protein insertion into ER membrane" hsa04141 Protein processing in endoplasmic reticulum TRAM2 1682.615745 1908.119061 1457.112429 0.763638108 -0.389038995 0.101482186 1 14.06142051 10.5581534 9697 translocation associated membrane protein 2 "GO:0005515,GO:0006616,GO:0030176,GO:0032964,GO:0045048" "protein binding|SRP-dependent cotranslational protein targeting to membrane, translocation|integral component of endoplasmic reticulum membrane|collagen biosynthetic process|protein insertion into ER membrane" TRANK1 489.7795008 620.0866741 359.4723275 0.579713035 -0.78658917 0.004249895 0.400809036 2.782551595 1.586088696 9881 tetratricopeptide repeat and ankyrin repeat containing 1 TRAP1 1817.851271 1925.806097 1709.896446 0.88788609 -0.171553495 0.469816675 1 44.93954172 39.23350154 10131 TNF receptor associated protein 1 "GO:0003723,GO:0005164,GO:0005515,GO:0005524,GO:0005654,GO:0005739,GO:0005743,GO:0005758,GO:0005759,GO:0006457,GO:0009386,GO:0016020,GO:0019901,GO:0051082,GO:0061077,GO:1901856,GO:1903427,GO:1903751" RNA binding|tumor necrosis factor receptor binding|protein binding|ATP binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|protein folding|translational attenuation|membrane|protein kinase binding|unfolded protein binding|chaperone-mediated protein folding|negative regulation of cellular respiration|negative regulation of reactive oxygen species biosynthetic process|negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide "hsa05012,hsa05022" Parkinson disease|Pathways of neurodegeneration - multiple diseases TRAPPC1 1760.070515 1506.519302 2013.621728 1.336605329 0.418573532 0.077783361 1 92.52032944 121.5938298 58485 trafficking protein particle complex subunit 1 "GO:0000139,GO:0005515,GO:0005576,GO:0005783,GO:0005829,GO:0006888,GO:0030008,GO:0035578,GO:0043312,GO:0048208" Golgi membrane|protein binding|extracellular region|endoplasmic reticulum|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|TRAPP complex|azurophil granule lumen|neutrophil degranulation|COPII vesicle coating TRAPPC10 946.7771322 997.7569135 895.797351 0.897811219 -0.15551597 0.530789897 1 6.285228125 5.548521228 7109 trafficking protein particle complex subunit 10 "GO:0000139,GO:0005515,GO:0005829,GO:0006891,GO:0030008,GO:0034498,GO:0048208,GO:1990071" Golgi membrane|protein binding|cytosol|intra-Golgi vesicle-mediated transport|TRAPP complex|early endosome to Golgi transport|COPII vesicle coating|TRAPPII protein complex TRAPPC11 1015.692897 1015.443949 1015.941845 1.000490323 0.000707214 1 1 9.512441158 9.357849462 60684 trafficking protein particle complex subunit 11 "GO:0005515,GO:0005794,GO:0005829,GO:0006888,GO:0007030,GO:0030008,GO:0045054,GO:0061635" protein binding|Golgi apparatus|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|TRAPP complex|constitutive secretory pathway|regulation of protein complex stability TRAPPC12 818.6118815 925.9683556 711.2554074 0.768120642 -0.380595175 0.129211285 1 5.244320204 3.960862947 51112 trafficking protein particle complex subunit 12 "GO:0000776,GO:0004175,GO:0005515,GO:0005634,GO:0005654,GO:0005793,GO:0005794,GO:0005829,GO:0006508,GO:0006888,GO:0007030,GO:0030008,GO:0048471,GO:0051310,GO:0090234,GO:1905342" kinetochore|endopeptidase activity|protein binding|nucleus|nucleoplasm|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|proteolysis|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|TRAPP complex|perinuclear region of cytoplasm|metaphase plate congression|regulation of kinetochore assembly|positive regulation of protein localization to kinetochore TRAPPC13 376.191334 350.6194785 401.7631896 1.145866714 0.196439241 0.508066802 1 6.423589823 7.237408461 80006 trafficking protein particle complex subunit 13 "GO:0005515,GO:0005829,GO:1990072" protein binding|cytosol|TRAPPIII protein complex TRAPPC14 337.8293841 340.2153396 335.4434286 0.985973851 -0.020378709 0.957129377 1 7.106327744 6.889406479 55262 trafficking protein particle complex subunit 14 "GO:0005515,GO:0005886,GO:0030496,GO:0034451,GO:0042127,GO:0043014,GO:0043231,GO:0060271,GO:0072686,GO:1990071" protein binding|plasma membrane|midbody|centriolar satellite|regulation of cell population proliferation|alpha-tubulin binding|intracellular membrane-bounded organelle|cilium assembly|mitotic spindle|TRAPPII protein complex TRAPPC2 261.9829663 228.8910542 295.0748785 1.289149895 0.366420022 0.267769654 1 4.19200236 5.313688783 6399 trafficking protein particle complex subunit 2 "GO:0000139,GO:0001501,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005793,GO:0005829,GO:0006355,GO:0006888,GO:0008134,GO:0030008,GO:0043231,GO:0044325,GO:0048208,GO:0048471" "Golgi membrane|skeletal system development|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cytosol|regulation of transcription, DNA-templated|endoplasmic reticulum to Golgi vesicle-mediated transport|transcription factor binding|TRAPP complex|intracellular membrane-bounded organelle|ion channel binding|COPII vesicle coating|perinuclear region of cytoplasm" TRAPPC2B 47.27969541 42.65696919 51.90242162 1.216739553 0.283020388 0.666212562 1 3.059844147 3.660733478 10597 trafficking protein particle complex subunit 2B "GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005793,GO:0006888,GO:0030008,GO:0043231,GO:0048471" nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|endoplasmic reticulum to Golgi vesicle-mediated transport|TRAPP complex|intracellular membrane-bounded organelle|perinuclear region of cytoplasm TRAPPC2L 636.2765262 618.0058463 654.547206 1.059127854 0.082876757 0.754876031 1 13.19273447 13.73897679 51693 trafficking protein particle complex subunit 2L "GO:0000139,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0006888,GO:0030008,GO:0043231,GO:0048208,GO:0048471" Golgi membrane|protein binding|nucleus|cytoplasm|endoplasmic reticulum|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|TRAPP complex|intracellular membrane-bounded organelle|COPII vesicle coating|perinuclear region of cytoplasm TRAPPC3 880.9385636 896.8367668 865.0403604 0.964546049 -0.052077978 0.838405857 1 28.18759124 26.73327157 27095 trafficking protein particle complex subunit 3 "GO:0000139,GO:0005515,GO:0005783,GO:0005794,GO:0005829,GO:0006888,GO:0006891,GO:0030008,GO:0033106,GO:0048208" Golgi membrane|protein binding|endoplasmic reticulum|Golgi apparatus|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|TRAPP complex|cis-Golgi network membrane|COPII vesicle coating TRAPPC4 900.4151622 764.7042037 1036.126121 1.354937132 0.438225913 0.077653105 1 31.48985948 41.95280911 51399 trafficking protein particle complex subunit 4 "GO:0000139,GO:0005515,GO:0005783,GO:0005795,GO:0005829,GO:0006888,GO:0006914,GO:0008021,GO:0016358,GO:0030008,GO:0030425,GO:0045202,GO:0045211,GO:0048208" Golgi membrane|protein binding|endoplasmic reticulum|Golgi stack|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|autophagy|synaptic vesicle|dendrite development|TRAPP complex|dendrite|synapse|postsynaptic membrane|COPII vesicle coating TRAPPC5 305.378409 270.5076095 340.2492084 1.257817512 0.330922627 0.29166968 1 2.621004711 3.241579052 126003 trafficking protein particle complex subunit 5 "GO:0000139,GO:0005515,GO:0005783,GO:0005829,GO:0006888,GO:0030008,GO:0048208,GO:1990070,GO:1990071,GO:1990072" Golgi membrane|protein binding|endoplasmic reticulum|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|TRAPP complex|COPII vesicle coating|TRAPPI protein complex|TRAPPII protein complex|TRAPPIII protein complex TRAPPC6A 55.72692378 49.93986637 61.51398118 1.231761029 0.300722389 0.619826871 1 3.331498603 4.034941789 79090 trafficking protein particle complex subunit 6A "GO:0000139,GO:0005515,GO:0005783,GO:0005801,GO:0005802,GO:0005829,GO:0006888,GO:0030008,GO:0043087,GO:0048208,GO:1903232" Golgi membrane|protein binding|endoplasmic reticulum|cis-Golgi network|trans-Golgi network|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|TRAPP complex|regulation of GTPase activity|COPII vesicle coating|melanosome assembly TRAPPC6B 710.1660335 715.8047513 704.5273157 0.984245095 -0.022910476 0.934432452 1 10.14909245 9.822038826 122553 trafficking protein particle complex subunit 6B "GO:0000139,GO:0005515,GO:0005783,GO:0005801,GO:0005802,GO:0005829,GO:0006888,GO:0007399,GO:0030008,GO:0043087,GO:0048208" Golgi membrane|protein binding|endoplasmic reticulum|cis-Golgi network|trans-Golgi network|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|nervous system development|TRAPP complex|regulation of GTPase activity|COPII vesicle coating TRAPPC8 1363.628896 1419.124536 1308.133256 0.921788908 -0.117491687 0.6259324 1 11.57689823 10.49288401 22878 trafficking protein particle complex subunit 8 "GO:0000407,GO:0005515,GO:0005829,GO:0006888,GO:0007030,GO:0030008,GO:0030242,GO:0031410,GO:0034497,GO:1990072" phagophore assembly site|protein binding|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|TRAPP complex|autophagy of peroxisome|cytoplasmic vesicle|protein localization to phagophore assembly site|TRAPPIII protein complex TRAPPC9 629.286123 573.2680493 685.3041966 1.195434138 0.257534648 0.324160731 1 2.620942532 3.080734918 83696 trafficking protein particle complex subunit 9 "GO:0000139,GO:0005515,GO:0005783,GO:0005802,GO:0005829,GO:0021987,GO:0030008,GO:0030182,GO:0048208,GO:0051092" Golgi membrane|protein binding|endoplasmic reticulum|trans-Golgi network|cytosol|cerebral cortex development|TRAPP complex|neuron differentiation|COPII vesicle coating|positive regulation of NF-kappaB transcription factor activity TRDMT1 217.8094213 229.9314681 205.6873746 0.89455948 -0.160750683 0.656122191 1 0.795012624 0.699285344 1787 tRNA aspartic acid methyltransferase 1 "GO:0001975,GO:0003723,GO:0005654,GO:0005737,GO:0006400,GO:0008175,GO:0016428,GO:0030488,GO:0036416" response to amphetamine|RNA binding|nucleoplasm|cytoplasm|tRNA modification|tRNA methyltransferase activity|tRNA (cytosine-5-)-methyltransferase activity|tRNA methylation|tRNA stabilization TRERF1 646.2145639 702.2793708 590.149757 0.840334746 -0.250963956 0.334295686 1 3.114714476 2.573604108 55809 transcriptional regulating factor 1 "GO:0000118,GO:0001650,GO:0003677,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006357,GO:0008134,GO:0016575,GO:0030374,GO:0033142,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0050847,GO:0071393" "histone deacetylase complex|fibrillar center|DNA binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|regulation of transcription by RNA polymerase II|transcription factor binding|histone deacetylation|nuclear receptor coactivator activity|progesterone receptor binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|progesterone receptor signaling pathway|cellular response to progesterone stimulus" TRHDE 4.444088692 3.121241648 5.766935736 1.847641543 0.88568489 0.705170935 1 0.01596922 0.029011661 29953 thyrotropin releasing hormone degrading enzyme "GO:0004177,GO:0005737,GO:0005886,GO:0005887,GO:0006508,GO:0007165,GO:0007267,GO:0008217,GO:0008270,GO:0042277,GO:0043171,GO:0070006,GO:0070062" aminopeptidase activity|cytoplasm|plasma membrane|integral component of plasma membrane|proteolysis|signal transduction|cell-cell signaling|regulation of blood pressure|zinc ion binding|peptide binding|peptide catabolic process|metalloaminopeptidase activity|extracellular exosome TRIAP1 318.7352127 318.3666481 319.1037774 1.002315347 0.003336479 1 1 14.76163586 14.54822626 51499 TP53 regulated inhibitor of apoptosis 1 "GO:0002039,GO:0005515,GO:0005654,GO:0005739,GO:0005758,GO:0006915,GO:0006977,GO:0015914,GO:0030330,GO:0032991,GO:0034644,GO:0042981,GO:0043066,GO:0043154,GO:0045944,GO:0090201,GO:0097035,GO:0120009,GO:1902166,GO:1990050,GO:2001140" "p53 binding|protein binding|nucleoplasm|mitochondrion|mitochondrial intermembrane space|apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|phospholipid transport|DNA damage response, signal transduction by p53 class mediator|protein-containing complex|cellular response to UV|regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of transcription by RNA polymerase II|negative regulation of release of cytochrome c from mitochondria|regulation of membrane lipid distribution|intermembrane lipid transfer|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|phosphatidic acid transfer activity|positive regulation of phospholipid transport" TRIB1 596.8351478 503.5603192 690.1099764 1.370461393 0.454661687 0.084138308 1 7.239786835 9.755819654 10221 tribbles pseudokinase 1 "GO:0004672,GO:0004860,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0006469,GO:0007254,GO:0008134,GO:0014912,GO:0031434,GO:0031625,GO:0031665,GO:0032436,GO:0032496,GO:0043405,GO:0043433,GO:0045645,GO:0045651,GO:0045659,GO:0048662,GO:0055106" protein kinase activity|protein kinase inhibitor activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|negative regulation of protein kinase activity|JNK cascade|transcription factor binding|negative regulation of smooth muscle cell migration|mitogen-activated protein kinase kinase binding|ubiquitin protein ligase binding|negative regulation of lipopolysaccharide-mediated signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|response to lipopolysaccharide|regulation of MAP kinase activity|negative regulation of DNA-binding transcription factor activity|positive regulation of eosinophil differentiation|positive regulation of macrophage differentiation|negative regulation of neutrophil differentiation|negative regulation of smooth muscle cell proliferation|ubiquitin-protein transferase regulator activity TRIB3 1248.388332 1573.105791 923.6708737 0.587163864 -0.768164913 0.001514852 0.247303919 27.1871 15.69615876 57761 tribbles pseudokinase 3 "GO:0000122,GO:0003714,GO:0004860,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006468,GO:0006469,GO:0010506,GO:0010827,GO:0016301,GO:0019216,GO:0019901,GO:0031434,GO:0031625,GO:0032092,GO:0032436,GO:0032869,GO:0034976,GO:0043405,GO:0045599,GO:0045717,GO:0045892,GO:0051443,GO:0051898,GO:0055106,GO:0070059" "negative regulation of transcription by RNA polymerase II|transcription corepressor activity|protein kinase inhibitor activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|protein phosphorylation|negative regulation of protein kinase activity|regulation of autophagy|regulation of glucose transmembrane transport|kinase activity|regulation of lipid metabolic process|protein kinase binding|mitogen-activated protein kinase kinase binding|ubiquitin protein ligase binding|positive regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|cellular response to insulin stimulus|response to endoplasmic reticulum stress|regulation of MAP kinase activity|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of transcription, DNA-templated|positive regulation of ubiquitin-protein transferase activity|negative regulation of protein kinase B signaling|ubiquitin-protein transferase regulator activity|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" hsa04931 Insulin resistance TRIM11 574.2473685 604.4804658 544.0142711 0.899969977 -0.15205122 0.569634561 1 11.8865186 10.51850153 81559 tripartite motif containing 11 "GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0008134,GO:0008270,GO:0010468,GO:0016567,GO:0019904,GO:0032897,GO:0045087,GO:0045892,GO:0046597,GO:0046598,GO:0050768,GO:0051607,GO:0061630,GO:1902187" "protein binding|nucleoplasm|cytoplasm|cytosol|transcription factor binding|zinc ion binding|regulation of gene expression|protein ubiquitination|protein domain specific binding|negative regulation of viral transcription|innate immune response|negative regulation of transcription, DNA-templated|negative regulation of viral entry into host cell|positive regulation of viral entry into host cell|negative regulation of neurogenesis|defense response to virus|ubiquitin protein ligase activity|negative regulation of viral release from host cell" TRIM13 366.0299994 323.5687175 408.4912813 1.262456039 0.336233151 0.257657123 1 2.526817056 3.136615197 10206 tripartite motif containing 13 "GO:0003713,GO:0004842,GO:0005515,GO:0005737,GO:0005789,GO:0008270,GO:0009653,GO:0010332,GO:0010942,GO:0016021,GO:0016239,GO:0016567,GO:0030433,GO:0032897,GO:0043123,GO:0043161,GO:0044322,GO:0045087,GO:0045893,GO:0051092,GO:0051865,GO:0061630,GO:0097038,GO:1902187,GO:1904380" "transcription coactivator activity|ubiquitin-protein transferase activity|protein binding|cytoplasm|endoplasmic reticulum membrane|zinc ion binding|anatomical structure morphogenesis|response to gamma radiation|positive regulation of cell death|integral component of membrane|positive regulation of macroautophagy|protein ubiquitination|ubiquitin-dependent ERAD pathway|negative regulation of viral transcription|positive regulation of I-kappaB kinase/NF-kappaB signaling|proteasome-mediated ubiquitin-dependent protein catabolic process|endoplasmic reticulum quality control compartment|innate immune response|positive regulation of transcription, DNA-templated|positive regulation of NF-kappaB transcription factor activity|protein autoubiquitination|ubiquitin protein ligase activity|perinuclear endoplasmic reticulum|negative regulation of viral release from host cell|endoplasmic reticulum mannose trimming" TRIM14 1181.798042 1250.577487 1113.018597 0.890003705 -0.168116753 0.489105051 1 6.576118043 5.754831254 9830 tripartite motif containing 14 "GO:0000209,GO:0003713,GO:0005515,GO:0005654,GO:0005737,GO:0005741,GO:0005829,GO:0008270,GO:0010468,GO:0010508,GO:0016567,GO:0019901,GO:0032880,GO:0032897,GO:0042803,GO:0043123,GO:0045087,GO:0045335,GO:0045893,GO:0046596,GO:0051091,GO:0051092,GO:0061630" "protein polyubiquitination|transcription coactivator activity|protein binding|nucleoplasm|cytoplasm|mitochondrial outer membrane|cytosol|zinc ion binding|regulation of gene expression|positive regulation of autophagy|protein ubiquitination|protein kinase binding|regulation of protein localization|negative regulation of viral transcription|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|phagocytic vesicle|positive regulation of transcription, DNA-templated|regulation of viral entry into host cell|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|ubiquitin protein ligase activity" TRIM16 657.9805643 821.9269673 494.0341614 0.601068198 -0.734399404 0.00459834 0.412329403 13.06275509 7.720220665 10626 tripartite motif containing 16 "GO:0003677,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0008270,GO:0016605,GO:0016740,GO:0019966,GO:0032089,GO:0032526,GO:0032731,GO:0043966,GO:0043967,GO:0045618,GO:0045893,GO:0046683,GO:0048386,GO:0060416" "DNA binding|protein binding|cytoplasm|cytosol|plasma membrane|zinc ion binding|PML body|transferase activity|interleukin-1 binding|NACHT domain binding|response to retinoic acid|positive regulation of interleukin-1 beta production|histone H3 acetylation|histone H4 acetylation|positive regulation of keratinocyte differentiation|positive regulation of transcription, DNA-templated|response to organophosphorus|positive regulation of retinoic acid receptor signaling pathway|response to growth hormone" TRIM16L 504.5138718 628.4099851 380.6177586 0.605683817 -0.723363229 0.008058464 0.553766277 8.90286327 5.302087033 147166 tripartite motif containing 16 like "GO:0005829,GO:0005886" cytosol|plasma membrane TRIM2 376.6467599 413.0443114 340.2492084 0.82375958 -0.279704757 0.34297346 1 2.373833271 1.922745791 23321 tripartite motif containing 2 "GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0008270,GO:0043161,GO:0043523,GO:0061630" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of neuron apoptotic process|ubiquitin protein ligase activity TRIM21 508.9290068 504.6007331 513.2572805 1.017155241 0.024539885 0.935881824 1 13.91711303 13.91898524 6737 tripartite motif containing 21 "GO:0000209,GO:0000932,GO:0003677,GO:0003713,GO:0003723,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005776,GO:0005829,GO:0006513,GO:0007049,GO:0008270,GO:0010468,GO:0010508,GO:0016567,GO:0019005,GO:0019901,GO:0031410,GO:0031648,GO:0032088,GO:0032092,GO:0032479,GO:0032880,GO:0032897,GO:0034341,GO:0042802,GO:0042803,GO:0043123,GO:0045087,GO:0045787,GO:0045824,GO:0045893,GO:0046596,GO:0046598,GO:0051091,GO:0051092,GO:0051865,GO:0060333,GO:0061630,GO:0070534,GO:0090086,GO:1902187,GO:1990904" "protein polyubiquitination|P-body|DNA binding|transcription coactivator activity|RNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|autophagosome|cytosol|protein monoubiquitination|cell cycle|zinc ion binding|regulation of gene expression|positive regulation of autophagy|protein ubiquitination|SCF ubiquitin ligase complex|protein kinase binding|cytoplasmic vesicle|protein destabilization|negative regulation of NF-kappaB transcription factor activity|positive regulation of protein binding|regulation of type I interferon production|regulation of protein localization|negative regulation of viral transcription|response to interferon-gamma|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of cell cycle|negative regulation of innate immune response|positive regulation of transcription, DNA-templated|regulation of viral entry into host cell|positive regulation of viral entry into host cell|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|protein autoubiquitination|interferon-gamma-mediated signaling pathway|ubiquitin protein ligase activity|protein K63-linked ubiquitination|negative regulation of protein deubiquitination|negative regulation of viral release from host cell|ribonucleoprotein complex" hsa05322 Systemic lupus erythematosus TRIM22 164.2872426 174.7895323 153.784953 0.879829306 -0.184704438 0.646993448 1 3.229984795 2.794281017 10346 tripartite motif containing 22 "GO:0000209,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006355,GO:0006955,GO:0008270,GO:0009615,GO:0010468,GO:0010508,GO:0015030,GO:0016032,GO:0016567,GO:0016604,GO:0016607,GO:0019901,GO:0030674,GO:0032880,GO:0042802,GO:0042803,GO:0043123,GO:0045087,GO:0045892,GO:0045893,GO:0046596,GO:0051091,GO:0051092,GO:0051607,GO:0060333,GO:0061630" "protein polyubiquitination|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|regulation of transcription, DNA-templated|immune response|zinc ion binding|response to virus|regulation of gene expression|positive regulation of autophagy|Cajal body|viral process|protein ubiquitination|nuclear body|nuclear speck|protein kinase binding|protein-macromolecule adaptor activity|regulation of protein localization|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|regulation of viral entry into host cell|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|defense response to virus|interferon-gamma-mediated signaling pathway|ubiquitin protein ligase activity" TRIM23 378.7577702 342.2961674 415.219373 1.213041257 0.278628619 0.344374173 1 4.728893953 5.640353523 373 tripartite motif containing 23 "GO:0000139,GO:0003924,GO:0004842,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005765,GO:0005886,GO:0006886,GO:0008047,GO:0008270,GO:0016032,GO:0016192,GO:0016567,GO:0019003,GO:0042802,GO:0045087,GO:0050790" Golgi membrane|GTPase activity|ubiquitin-protein transferase activity|protein binding|GTP binding|nucleus|cytoplasm|lysosomal membrane|plasma membrane|intracellular protein transport|enzyme activator activity|zinc ion binding|viral process|vesicle-mediated transport|protein ubiquitination|GDP binding|identical protein binding|innate immune response|regulation of catalytic activity TRIM24 452.4390719 459.8629361 445.0152076 0.967712709 -0.047349286 0.873391889 1 5.524997683 5.257142189 8805 tripartite motif containing 24 "GO:0000791,GO:0002039,GO:0003682,GO:0003713,GO:0004672,GO:0005102,GO:0005515,GO:0005634,GO:0005654,GO:0005726,GO:0005829,GO:0006366,GO:0008270,GO:0008285,GO:0016567,GO:0016922,GO:0030163,GO:0031647,GO:0034056,GO:0035064,GO:0042981,GO:0045892,GO:0045893,GO:0046777,GO:0055074,GO:0061630,GO:0070562,GO:0070577,GO:0071391,GO:1901796" "euchromatin|p53 binding|chromatin binding|transcription coactivator activity|protein kinase activity|signaling receptor binding|protein binding|nucleus|nucleoplasm|perichromatin fibrils|cytosol|transcription by RNA polymerase II|zinc ion binding|negative regulation of cell population proliferation|protein ubiquitination|nuclear receptor binding|protein catabolic process|regulation of protein stability|estrogen response element binding|methylated histone binding|regulation of apoptotic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein autophosphorylation|calcium ion homeostasis|ubiquitin protein ligase activity|regulation of vitamin D receptor signaling pathway|lysine-acetylated histone binding|cellular response to estrogen stimulus|regulation of signal transduction by p53 class mediator" other TRIM25 2443.440611 2629.125881 2257.755341 0.858747524 -0.219694061 0.352810003 1 24.42325782 20.62245053 7706 tripartite motif containing 25 "GO:0003713,GO:0003723,GO:0005515,GO:0005654,GO:0005829,GO:0006511,GO:0006513,GO:0010494,GO:0016032,GO:0016604,GO:0016874,GO:0019985,GO:0030433,GO:0032480,GO:0032880,GO:0033280,GO:0039529,GO:0039552,GO:0043123,GO:0043627,GO:0045087,GO:0045296,GO:0045893,GO:0046596,GO:0046597,GO:0046872,GO:0051091,GO:0051092,GO:0060333,GO:0061630,GO:1902186,GO:1902187,GO:1990830" "transcription coactivator activity|RNA binding|protein binding|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein monoubiquitination|cytoplasmic stress granule|viral process|nuclear body|ligase activity|translesion synthesis|ubiquitin-dependent ERAD pathway|negative regulation of type I interferon production|regulation of protein localization|response to vitamin D|RIG-I signaling pathway|RIG-I binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to estrogen|innate immune response|cadherin binding|positive regulation of transcription, DNA-templated|regulation of viral entry into host cell|negative regulation of viral entry into host cell|metal ion binding|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|interferon-gamma-mediated signaling pathway|ubiquitin protein ligase activity|regulation of viral release from host cell|negative regulation of viral release from host cell|cellular response to leukemia inhibitory factor" "hsa04064,hsa04622,hsa05164" NF-kappa B signaling pathway|RIG-I-like receptor signaling pathway|Influenza A TRIM26 481.3825766 487.954111 474.8110423 0.973064949 -0.039391991 0.893966854 1 7.398072182 7.078342485 7726 tripartite motif containing 26 "GO:0003677,GO:0005515,GO:0005575,GO:0005634,GO:0005737,GO:0005829,GO:0008270,GO:0010468,GO:0016567,GO:0045087,GO:0046597,GO:0046872,GO:0051091,GO:0060333,GO:0061630,GO:1902187" DNA binding|protein binding|cellular_component|nucleus|cytoplasm|cytosol|zinc ion binding|regulation of gene expression|protein ubiquitination|innate immune response|negative regulation of viral entry into host cell|metal ion binding|positive regulation of DNA-binding transcription factor activity|interferon-gamma-mediated signaling pathway|ubiquitin protein ligase activity|negative regulation of viral release from host cell TRIM27 1290.388543 1300.517353 1280.259733 0.984423414 -0.022649122 0.928416432 1 23.42430675 22.6735676 5987 tripartite motif containing 27 "GO:0000122,GO:0000209,GO:0001650,GO:0002820,GO:0003676,GO:0003677,GO:0003713,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0006469,GO:0007283,GO:0008270,GO:0010468,GO:0010508,GO:0016567,GO:0016605,GO:0019901,GO:0030904,GO:0031965,GO:0032609,GO:0032703,GO:0032720,GO:0032880,GO:0032897,GO:0034314,GO:0042147,GO:0042802,GO:0042803,GO:0043123,GO:0045087,GO:0045814,GO:0045893,GO:0046596,GO:0046872,GO:0051091,GO:0051092,GO:0061630,GO:0070534,GO:0090281" "negative regulation of transcription by RNA polymerase II|protein polyubiquitination|fibrillar center|negative regulation of adaptive immune response|nucleic acid binding|DNA binding|transcription coactivator activity|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|endosome|early endosome|cytosol|negative regulation of protein kinase activity|spermatogenesis|zinc ion binding|regulation of gene expression|positive regulation of autophagy|protein ubiquitination|PML body|protein kinase binding|retromer complex|nuclear membrane|interferon-gamma production|negative regulation of interleukin-2 production|negative regulation of tumor necrosis factor production|regulation of protein localization|negative regulation of viral transcription|Arp2/3 complex-mediated actin nucleation|retrograde transport, endosome to Golgi|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|negative regulation of gene expression, epigenetic|positive regulation of transcription, DNA-templated|regulation of viral entry into host cell|metal ion binding|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|ubiquitin protein ligase activity|protein K63-linked ubiquitination|negative regulation of calcium ion import" TRIM28 3611.382993 3579.023756 3643.742229 1.018082717 0.025854782 0.914479615 1 54.8552326 54.91263757 10155 tripartite motif containing 28 "GO:0000122,GO:0000785,GO:0000791,GO:0000792,GO:0001837,GO:0003677,GO:0003682,GO:0003713,GO:0003714,GO:0003723,GO:0004672,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006325,GO:0006367,GO:0007265,GO:0007566,GO:0008270,GO:0016032,GO:0016567,GO:0016925,GO:0019789,GO:0031625,GO:0032991,GO:0035851,GO:0042307,GO:0043045,GO:0043388,GO:0045087,GO:0045739,GO:0045869,GO:0045892,GO:0045893,GO:0046777,GO:0060028,GO:0060669,GO:0070087,GO:0090309,GO:0090575,GO:1901536,GO:1902187,GO:1990841,GO:2000653" "negative regulation of transcription by RNA polymerase II|chromatin|euchromatin|heterochromatin|epithelial to mesenchymal transition|DNA binding|chromatin binding|transcription coactivator activity|transcription corepressor activity|RNA binding|protein kinase activity|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|DNA repair|chromatin organization|transcription initiation from RNA polymerase II promoter|Ras protein signal transduction|embryo implantation|zinc ion binding|viral process|protein ubiquitination|protein sumoylation|SUMO transferase activity|ubiquitin protein ligase binding|protein-containing complex|Krueppel-associated box domain binding|positive regulation of protein import into nucleus|DNA methylation involved in embryo development|positive regulation of DNA binding|innate immune response|positive regulation of DNA repair|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein autophosphorylation|convergent extension involved in axis elongation|embryonic placenta morphogenesis|chromo shadow domain binding|positive regulation of DNA methylation-dependent heterochromatin assembly|RNA polymerase II transcription regulator complex|negative regulation of DNA demethylation|negative regulation of viral release from host cell|promoter-specific chromatin binding|regulation of genetic imprinting" other TRIM3 418.4916425 426.5696919 410.4135932 0.962125535 -0.05570295 0.853304531 1 6.733286144 6.36986152 10612 tripartite motif containing 3 "GO:0000209,GO:0005515,GO:0005737,GO:0005769,GO:0005794,GO:0007399,GO:0008022,GO:0008270,GO:0015031,GO:0030425,GO:0042802,GO:0043161,GO:0061630" protein polyubiquitination|protein binding|cytoplasm|early endosome|Golgi apparatus|nervous system development|protein C-terminus binding|zinc ion binding|protein transport|dendrite|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity TRIM32 827.0496634 857.3010393 796.7982875 0.92942648 -0.105587346 0.676670697 1 11.81321477 10.79578732 22954 tripartite motif containing 32 "GO:0000209,GO:0001894,GO:0003713,GO:0003723,GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005863,GO:0006511,GO:0007014,GO:0008270,GO:0009411,GO:0016567,GO:0017022,GO:0030307,GO:0030335,GO:0030957,GO:0031369,GO:0032479,GO:0032897,GO:0034612,GO:0042802,GO:0043123,GO:0043130,GO:0043621,GO:0045087,GO:0045444,GO:0045666,GO:0045732,GO:0045787,GO:0045862,GO:0045893,GO:0046716,GO:0048147,GO:0050769,GO:0051091,GO:0051092,GO:0051155,GO:0061564,GO:0061630,GO:0070936,GO:1902187,GO:1902230,GO:1903265,GO:1903883,GO:1903886,GO:2000147" "protein polyubiquitination|tissue homeostasis|transcription coactivator activity|RNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|cytosol|striated muscle myosin thick filament|ubiquitin-dependent protein catabolic process|actin ubiquitination|zinc ion binding|response to UV|protein ubiquitination|myosin binding|positive regulation of cell growth|positive regulation of cell migration|Tat protein binding|translation initiation factor binding|regulation of type I interferon production|negative regulation of viral transcription|response to tumor necrosis factor|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|protein self-association|innate immune response|fat cell differentiation|positive regulation of neuron differentiation|positive regulation of protein catabolic process|positive regulation of cell cycle|positive regulation of proteolysis|positive regulation of transcription, DNA-templated|muscle cell cellular homeostasis|negative regulation of fibroblast proliferation|positive regulation of neurogenesis|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of striated muscle cell differentiation|axon development|ubiquitin protein ligase activity|protein K48-linked ubiquitination|negative regulation of viral release from host cell|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of interleukin-17-mediated signaling pathway|positive regulation of chemokine (C-C motif) ligand 20 production|positive regulation of cell motility" hsa04120 Ubiquitin mediated proteolysis TRIM33 1385.576353 1515.883027 1255.269679 0.828078193 -0.27216109 0.256219669 1 9.570553777 7.792549947 51592 tripartite motif containing 33 "GO:0000122,GO:0003677,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0008270,GO:0016567,GO:0017015,GO:0030514,GO:0045892,GO:0070410,GO:0070412" "negative regulation of transcription by RNA polymerase II|DNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|zinc ion binding|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-templated|co-SMAD binding|R-SMAD binding" TRIM35 436.2975654 465.0650055 407.5301253 0.87628637 -0.190525677 0.503327765 1 5.828948941 5.022355914 23087 tripartite motif containing 35 "GO:0003674,GO:0005634,GO:0005737,GO:0006915,GO:0008270,GO:0016567,GO:0043065,GO:0045087,GO:0045930,GO:0061630,GO:1902187" molecular_function|nucleus|cytoplasm|apoptotic process|zinc ion binding|protein ubiquitination|positive regulation of apoptotic process|innate immune response|negative regulation of mitotic cell cycle|ubiquitin protein ligase activity|negative regulation of viral release from host cell TRIM36 466.9312531 373.5085839 560.3539223 1.50024376 0.585196929 0.035250961 0.95006405 3.920052437 5.782623065 55521 tripartite motif containing 36 "GO:0000209,GO:0000281,GO:0001669,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0007051,GO:0007340,GO:0008270,GO:0043014,GO:0051726,GO:0070507" protein polyubiquitination|mitotic cytokinesis|acrosomal vesicle|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|cytoskeleton|spindle organization|acrosome reaction|zinc ion binding|alpha-tubulin binding|regulation of cell cycle|regulation of microtubule cytoskeleton organization TRIM37 2468.786712 2739.409753 2198.163671 0.802422372 -0.317566266 0.179137115 1 18.17017943 14.33617927 4591 tripartite motif containing 37 "GO:0000122,GO:0003682,GO:0003713,GO:0004842,GO:0005164,GO:0005515,GO:0005737,GO:0005777,GO:0005829,GO:0008270,GO:0016235,GO:0031625,GO:0032088,GO:0035098,GO:0035518,GO:0036353,GO:0042803,GO:0045893,GO:0046600,GO:0048471,GO:0051091,GO:0051092,GO:0051865,GO:0061630,GO:0070842" "negative regulation of transcription by RNA polymerase II|chromatin binding|transcription coactivator activity|ubiquitin-protein transferase activity|tumor necrosis factor receptor binding|protein binding|cytoplasm|peroxisome|cytosol|zinc ion binding|aggresome|ubiquitin protein ligase binding|negative regulation of NF-kappaB transcription factor activity|ESC/E(Z) complex|histone H2A monoubiquitination|histone H2A-K119 monoubiquitination|protein homodimerization activity|positive regulation of transcription, DNA-templated|negative regulation of centriole replication|perinuclear region of cytoplasm|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|protein autoubiquitination|ubiquitin protein ligase activity|aggresome assembly" hsa04120 Ubiquitin mediated proteolysis TRIM38 965.1233837 987.3527746 942.8939928 0.954971736 -0.066470061 0.791019639 1 7.221214596 6.78065968 10475 tripartite motif containing 38 "GO:0000209,GO:0003713,GO:0005515,GO:0005575,GO:0005654,GO:0005737,GO:0005829,GO:0008270,GO:0010468,GO:0010508,GO:0016567,GO:0019901,GO:0032880,GO:0042803,GO:0043123,GO:0045087,GO:0045893,GO:0046596,GO:0046598,GO:0051091,GO:0051092,GO:0060333,GO:0061630" "protein polyubiquitination|transcription coactivator activity|protein binding|cellular_component|nucleoplasm|cytoplasm|cytosol|zinc ion binding|regulation of gene expression|positive regulation of autophagy|protein ubiquitination|protein kinase binding|regulation of protein localization|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of transcription, DNA-templated|regulation of viral entry into host cell|positive regulation of viral entry into host cell|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|interferon-gamma-mediated signaling pathway|ubiquitin protein ligase activity" TRIM39 164.9068292 127.9709076 201.8427508 1.577254976 0.657415902 0.093277044 1 1.677203373 2.601110559 56658 tripartite motif containing 39 "GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006915,GO:0007095,GO:0008270,GO:0010468,GO:0016567,GO:0032435,GO:0042802,GO:0043124,GO:0045087,GO:0050821,GO:0061630,GO:1902806,GO:2000059,GO:2001235" protein binding|nucleus|cytoplasm|mitochondrion|cytosol|apoptotic process|mitotic G2 DNA damage checkpoint|zinc ion binding|regulation of gene expression|protein ubiquitination|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|identical protein binding|negative regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|protein stabilization|ubiquitin protein ligase activity|regulation of cell cycle G1/S phase transition|negative regulation of ubiquitin-dependent protein catabolic process|positive regulation of apoptotic signaling pathway TRIM4 980.3483936 970.7061525 989.9906347 1.019866447 0.028380241 0.91251607 1 15.27264248 15.31541142 89122 tripartite motif containing 4 "GO:0005737,GO:0005829,GO:0005886,GO:0008270,GO:0010468,GO:0016567,GO:0042802,GO:0045087,GO:0061630" cytoplasm|cytosol|plasma membrane|zinc ion binding|regulation of gene expression|protein ubiquitination|identical protein binding|innate immune response|ubiquitin protein ligase activity TRIM41 436.1591713 410.9634836 461.3548589 1.122617647 0.166866643 0.558917708 1 8.060406396 8.897335808 90933 tripartite motif containing 41 "GO:0005515,GO:0005730,GO:0005737,GO:0008270,GO:0016567,GO:0016604,GO:0042802,GO:0051091,GO:0061630,GO:0071222,GO:0071225" protein binding|nucleolus|cytoplasm|zinc ion binding|protein ubiquitination|nuclear body|identical protein binding|positive regulation of DNA-binding transcription factor activity|ubiquitin protein ligase activity|cellular response to lipopolysaccharide|cellular response to muramyl dipeptide TRIM44 3094.849027 3064.018884 3125.679169 1.02012399 0.028744513 0.9047408 1 12.50447782 12.54266145 54765 tripartite motif containing 44 "GO:0001961,GO:0002230,GO:0005515,GO:0005737,GO:0008270,GO:0010468,GO:0016567,GO:0045893,GO:0050821,GO:0061630,GO:0061944,GO:1901224" "positive regulation of cytokine-mediated signaling pathway|positive regulation of defense response to virus by host|protein binding|cytoplasm|zinc ion binding|regulation of gene expression|protein ubiquitination|positive regulation of transcription, DNA-templated|protein stabilization|ubiquitin protein ligase activity|negative regulation of protein K48-linked ubiquitination|positive regulation of NIK/NF-kappaB signaling" TRIM45 313.6174317 297.5583704 329.6764929 1.107938898 0.147878319 0.640144103 1 2.293161493 2.498167931 80263 tripartite motif containing 45 "GO:0000785,GO:0004842,GO:0005654,GO:0005829,GO:0008270,GO:0016567,GO:0045171,GO:0045893,GO:0060348" "chromatin|ubiquitin-protein transferase activity|nucleoplasm|cytosol|zinc ion binding|protein ubiquitination|intercellular bridge|positive regulation of transcription, DNA-templated|bone development" TRIM46 49.32089421 45.77821084 52.86357758 1.154775965 0.207612985 0.757117941 1 0.590263101 0.670215627 80128 tripartite motif containing 46 "GO:0001578,GO:0001764,GO:0005856,GO:0007409,GO:0008270,GO:0030517,GO:0043194,GO:0044304,GO:0048490,GO:0099612,GO:1901953,GO:1903827,GO:1904115,GO:1990769" microtubule bundle formation|neuron migration|cytoskeleton|axonogenesis|zinc ion binding|negative regulation of axon extension|axon initial segment|main axon|anterograde synaptic vesicle transport|protein localization to axon|positive regulation of anterograde dense core granule transport|regulation of cellular protein localization|axon cytoplasm|proximal neuron projection TRIM47 391.193047 391.1956199 391.1904741 0.999986846 -1.90E-05 1 1 8.630587534 8.486054713 91107 tripartite motif containing 47 "GO:0004842,GO:0005634,GO:0005829,GO:0008270,GO:0016567" ubiquitin-protein transferase activity|nucleus|cytosol|zinc ion binding|protein ubiquitination TRIM49 3.403674809 1.040413883 5.766935736 5.54292463 2.470647391 0.304382079 1 0.019002388 0.103566268 57093 tripartite motif containing 49 "GO:0005515,GO:0005737,GO:0008270,GO:0010468,GO:0016567,GO:0019901,GO:0045087,GO:0061630" protein binding|cytoplasm|zinc ion binding|regulation of gene expression|protein ubiquitination|protein kinase binding|innate immune response|ubiquitin protein ligase activity TRIM5 978.4908627 909.3217334 1047.659992 1.152133457 0.20430784 0.407851405 1 10.93484219 12.38758041 85363 tripartite motif containing 5 "GO:0000209,GO:0000932,GO:0002218,GO:0003713,GO:0004842,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006914,GO:0008270,GO:0010468,GO:0010508,GO:0016032,GO:0016567,GO:0019901,GO:0030674,GO:0031664,GO:0032880,GO:0038187,GO:0042802,GO:0042803,GO:0043123,GO:0043410,GO:0045087,GO:0045893,GO:0046596,GO:0046597,GO:0051091,GO:0051092,GO:0051607,GO:0060333,GO:0061630,GO:0070534,GO:1902187,GO:1990462" "protein polyubiquitination|P-body|activation of innate immune response|transcription coactivator activity|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytoplasm|cytosol|autophagy|zinc ion binding|regulation of gene expression|positive regulation of autophagy|viral process|protein ubiquitination|protein kinase binding|protein-macromolecule adaptor activity|regulation of lipopolysaccharide-mediated signaling pathway|regulation of protein localization|pattern recognition receptor activity|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAPK cascade|innate immune response|positive regulation of transcription, DNA-templated|regulation of viral entry into host cell|negative regulation of viral entry into host cell|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|defense response to virus|interferon-gamma-mediated signaling pathway|ubiquitin protein ligase activity|protein K63-linked ubiquitination|negative regulation of viral release from host cell|omegasome" hsa05170 Human immunodeficiency virus 1 infection TRIM52 329.2682993 317.3262342 341.2103644 1.0752668 0.104694672 0.739830395 1 2.167001651 2.29111378 84851 tripartite motif containing 52 "GO:0003713,GO:0005634,GO:0005737,GO:0005829,GO:0008270,GO:0016567,GO:0016604,GO:0043123,GO:0045893,GO:0051091,GO:0051092,GO:0051607,GO:0051865,GO:0061630" "transcription coactivator activity|nucleus|cytoplasm|cytosol|zinc ion binding|protein ubiquitination|nuclear body|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription, DNA-templated|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|defense response to virus|protein autoubiquitination|ubiquitin protein ligase activity" TRIM55 470.0034193 302.7604398 637.2463988 2.104787531 1.073674607 0.000125308 0.04393817 3.813492619 7.892277573 84675 tripartite motif containing 55 "GO:0002523,GO:0005515,GO:0005634,GO:0005737,GO:0005874,GO:0007165,GO:0008270,GO:0016567,GO:0042802,GO:0050904,GO:0061630,GO:1905517" leukocyte migration involved in inflammatory response|protein binding|nucleus|cytoplasm|microtubule|signal transduction|zinc ion binding|protein ubiquitination|identical protein binding|diapedesis|ubiquitin protein ligase activity|macrophage migration TRIM56 2010.556167 2241.051503 1780.060831 0.794297154 -0.332249261 0.160243396 1 10.90551654 8.517270212 81844 tripartite motif containing 56 "GO:0000785,GO:0003723,GO:0004842,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0008270,GO:0032479,GO:0032608,GO:0034340,GO:0045087,GO:0045893,GO:0051607,GO:0070534" "chromatin|RNA binding|ubiquitin-protein transferase activity|protein binding|nucleoplasm|cytoplasm|cytosol|zinc ion binding|regulation of type I interferon production|interferon-beta production|response to type I interferon|innate immune response|positive regulation of transcription, DNA-templated|defense response to virus|protein K63-linked ubiquitination" TRIM59 498.6286636 524.3685969 472.8887303 0.901825039 -0.149080528 0.589484304 1 7.318145467 6.48925 286827 tripartite motif containing 59 "GO:0005515,GO:0005783,GO:0005789,GO:0008270,GO:0016021,GO:0016567,GO:0030992,GO:0043124,GO:0045087,GO:0061630" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|zinc ion binding|integral component of membrane|protein ubiquitination|intraciliary transport particle B|negative regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|ubiquitin protein ligase activity TRIM6 183.5896197 176.87036 190.3088793 1.075979487 0.105650574 0.790897976 1 2.702332105 2.858998262 117854 tripartite motif containing 6 "GO:0000209,GO:0002230,GO:0002720,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0008134,GO:0008270,GO:0010468,GO:0010508,GO:0010629,GO:0010800,GO:0010994,GO:0016032,GO:0016567,GO:0019901,GO:0030674,GO:0032496,GO:0032880,GO:0033138,GO:0035458,GO:0042802,GO:0042803,GO:0043123,GO:0045071,GO:0045087,GO:0045892,GO:0046596,GO:0051092,GO:0060340,GO:0061630,GO:0098586,GO:1901222,GO:1990782,GO:2000679,GO:2000737" "protein polyubiquitination|positive regulation of defense response to virus by host|positive regulation of cytokine production involved in immune response|protein binding|nucleoplasm|cytoplasm|cytosol|transcription factor binding|zinc ion binding|regulation of gene expression|positive regulation of autophagy|negative regulation of gene expression|positive regulation of peptidyl-threonine phosphorylation|free ubiquitin chain polymerization|viral process|protein ubiquitination|protein kinase binding|protein-macromolecule adaptor activity|response to lipopolysaccharide|regulation of protein localization|positive regulation of peptidyl-serine phosphorylation|cellular response to interferon-beta|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of viral genome replication|innate immune response|negative regulation of transcription, DNA-templated|regulation of viral entry into host cell|positive regulation of NF-kappaB transcription factor activity|positive regulation of type I interferon-mediated signaling pathway|ubiquitin protein ligase activity|cellular response to virus|regulation of NIK/NF-kappaB signaling|protein tyrosine kinase binding|positive regulation of transcription regulatory region DNA binding|negative regulation of stem cell differentiation" TRIM62 201.5936874 220.5677431 182.6196316 0.827952578 -0.272379956 0.456617844 1 1.650027343 1.343283817 55223 tripartite motif containing 62 "GO:0003713,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0008270,GO:0010719,GO:0016567,GO:0032897,GO:0042802,GO:0043123,GO:0045087,GO:0045893,GO:0046596,GO:0051091,GO:0051092,GO:0060333,GO:0061630,GO:1902186" "transcription coactivator activity|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|zinc ion binding|negative regulation of epithelial to mesenchymal transition|protein ubiquitination|negative regulation of viral transcription|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of transcription, DNA-templated|regulation of viral entry into host cell|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|interferon-gamma-mediated signaling pathway|ubiquitin protein ligase activity|regulation of viral release from host cell" TRIM65 741.1255849 809.4420007 672.8091692 0.831201209 -0.266730343 0.294366392 1 10.90318826 8.911090523 201292 tripartite motif containing 65 "GO:0005654,GO:0005829,GO:0008270,GO:0010508" nucleoplasm|cytosol|zinc ion binding|positive regulation of autophagy TRIM66 456.2736349 484.8328693 427.7144004 0.882189364 -0.180839729 0.520717499 1 1.685314867 1.46188782 9866 tripartite motif containing 66 "GO:0005654,GO:0008270,GO:0016235" nucleoplasm|zinc ion binding|aggresome TRIM68 496.5528663 507.7219747 485.3837578 0.956003053 -0.06491287 0.819100487 1 8.151681299 7.662626367 55128 tripartite motif containing 68 "GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0008270,GO:0010468,GO:0010508,GO:0016567,GO:0019901,GO:0032880,GO:0035035,GO:0042802,GO:0042803,GO:0043123,GO:0045087,GO:0046596,GO:0048471,GO:0050681,GO:0051092,GO:0051865,GO:0060333,GO:0060765,GO:0061630" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|Golgi apparatus|cytosol|zinc ion binding|regulation of gene expression|positive regulation of autophagy|protein ubiquitination|protein kinase binding|regulation of protein localization|histone acetyltransferase binding|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|regulation of viral entry into host cell|perinuclear region of cytoplasm|androgen receptor binding|positive regulation of NF-kappaB transcription factor activity|protein autoubiquitination|interferon-gamma-mediated signaling pathway|regulation of androgen receptor signaling pathway|ubiquitin protein ligase activity TRIM7 299.5221545 293.3967149 305.647594 1.041755338 0.059016493 0.861507071 1 2.821777516 2.890411536 81786 tripartite motif containing 7 "GO:0005515,GO:0005634,GO:0005737,GO:0005794,GO:0008270,GO:0016567,GO:0061630" protein binding|nucleus|cytoplasm|Golgi apparatus|zinc ion binding|protein ubiquitination|ubiquitin protein ligase activity TRIM73 6.524916457 7.282897178 5.766935736 0.791846376 -0.336707531 0.922510643 1 0.287907287 0.224163433 375593 tripartite motif containing 73 "GO:0005737,GO:0005829,GO:0008270,GO:0016567,GO:0061630" cytoplasm|cytosol|zinc ion binding|protein ubiquitination|ubiquitin protein ligase activity TRIM74 111.5626736 127.9709076 95.15443964 0.74356306 -0.427472995 0.34581332 1 2.196003902 1.605543557 378108 tripartite motif containing 74 "GO:0005737,GO:0005829,GO:0008270,GO:0016567,GO:0061630" cytoplasm|cytosol|zinc ion binding|protein ubiquitination|ubiquitin protein ligase activity TRIM8 5928.301304 5636.962416 6219.640191 1.103367334 0.141913174 0.557803674 1 108.9979434 118.2523022 81603 tripartite motif containing 8 "GO:0003713,GO:0005515,GO:0005829,GO:0008270,GO:0010508,GO:0016567,GO:0016605,GO:0016740,GO:0019827,GO:0032897,GO:0042802,GO:0042803,GO:0043123,GO:0045087,GO:0045893,GO:0046597,GO:0051091,GO:0051092,GO:0060333,GO:1900182,GO:1902187" "transcription coactivator activity|protein binding|cytosol|zinc ion binding|positive regulation of autophagy|protein ubiquitination|PML body|transferase activity|stem cell population maintenance|negative regulation of viral transcription|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of transcription, DNA-templated|negative regulation of viral entry into host cell|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|interferon-gamma-mediated signaling pathway|positive regulation of protein localization to nucleus|negative regulation of viral release from host cell" TRIM9 29.86000131 39.53572754 20.18427508 0.510532532 -0.969925201 0.184211076 1 0.242857863 0.121912088 114088 tripartite motif containing 9 "GO:0000149,GO:0005515,GO:0005737,GO:0005856,GO:0008021,GO:0008270,GO:0016079,GO:0016567,GO:0019904,GO:0030425,GO:0035544,GO:0042803,GO:0043161,GO:0045955,GO:0061630,GO:0099523" SNARE binding|protein binding|cytoplasm|cytoskeleton|synaptic vesicle|zinc ion binding|synaptic vesicle exocytosis|protein ubiquitination|protein domain specific binding|dendrite|negative regulation of SNARE complex assembly|protein homodimerization activity|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of calcium ion-dependent exocytosis|ubiquitin protein ligase activity|presynaptic cytosol TRIML2 1970.666851 1648.01559 2293.318111 1.391563359 0.476706598 0.044165019 1 38.60911463 52.82798018 205860 tripartite motif family like 2 "GO:0000209,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0010468,GO:0010508,GO:0016567,GO:0019901,GO:0032526,GO:0032880,GO:0042802,GO:0042803,GO:0043123,GO:0045087,GO:0046596,GO:0051092,GO:0061630" protein polyubiquitination|protein binding|nucleoplasm|cytoplasm|cytosol|regulation of gene expression|positive regulation of autophagy|protein ubiquitination|protein kinase binding|response to retinoic acid|regulation of protein localization|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|regulation of viral entry into host cell|positive regulation of NF-kappaB transcription factor activity|ubiquitin protein ligase activity TRIO 4063.601341 4487.305076 3639.897605 0.811154478 -0.301951405 0.205095231 1 11.92091317 9.507892724 7204 trio Rho guanine nucleotide exchange factor "GO:0004674,GO:0005085,GO:0005515,GO:0005524,GO:0005829,GO:0006468,GO:0007185,GO:0007186,GO:0007411,GO:0007417,GO:0042995,GO:0043065,GO:0045599,GO:0048812,GO:0050790,GO:0051056,GO:0106310,GO:0106311" protein serine/threonine kinase activity|guanyl-nucleotide exchange factor activity|protein binding|ATP binding|cytosol|protein phosphorylation|transmembrane receptor protein tyrosine phosphatase signaling pathway|G protein-coupled receptor signaling pathway|axon guidance|central nervous system development|cell projection|positive regulation of apoptotic process|negative regulation of fat cell differentiation|neuron projection morphogenesis|regulation of catalytic activity|regulation of small GTPase mediated signal transduction|protein serine kinase activity|protein threonine kinase activity TRIOBP 2152.916689 2168.222531 2137.610846 0.985881668 -0.020513599 0.932903756 1 10.70435259 10.37663106 11078 TRIO and F-actin binding protein "GO:0005634,GO:0005737,GO:0005815,GO:0005925,GO:0007015,GO:0007049,GO:0007605,GO:0015629,GO:0030047,GO:0030496,GO:0031267,GO:0031625,GO:0045159,GO:0051015,GO:0051016,GO:0051301,GO:0060088,GO:0120044,GO:1900026" nucleus|cytoplasm|microtubule organizing center|focal adhesion|actin filament organization|cell cycle|sensory perception of sound|actin cytoskeleton|actin modification|midbody|small GTPase binding|ubiquitin protein ligase binding|myosin II binding|actin filament binding|barbed-end actin filament capping|cell division|auditory receptor cell stereocilium organization|stereocilium base|positive regulation of substrate adhesion-dependent cell spreading TRIP10 2117.840141 2054.817418 2180.862864 1.061341433 0.085888846 0.717782063 1 46.94427612 48.99016973 9322 thyroid hormone receptor interactor 10 "GO:0001891,GO:0005515,GO:0005654,GO:0005737,GO:0005764,GO:0005794,GO:0005829,GO:0005856,GO:0005938,GO:0006897,GO:0007154,GO:0007165,GO:0008289,GO:0030036,GO:0042802,GO:0042995,GO:0043231,GO:0048471,GO:0051056,GO:0061024,GO:0070062" phagocytic cup|protein binding|nucleoplasm|cytoplasm|lysosome|Golgi apparatus|cytosol|cytoskeleton|cell cortex|endocytosis|cell communication|signal transduction|lipid binding|actin cytoskeleton organization|identical protein binding|cell projection|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|regulation of small GTPase mediated signal transduction|membrane organization|extracellular exosome hsa04910 Insulin signaling pathway TRIP11 853.3720118 930.1300111 776.6140124 0.834952107 -0.260234648 0.297816764 1 4.950072715 4.063912252 9321 thyroid hormone receptor interactor 11 "GO:0000139,GO:0002079,GO:0002081,GO:0003281,GO:0003413,GO:0003713,GO:0005515,GO:0005654,GO:0005793,GO:0005794,GO:0005801,GO:0005856,GO:0005929,GO:0006366,GO:0006486,GO:0016607,GO:0030133,GO:0033116,GO:0035735,GO:0045893,GO:0051216,GO:0060122,GO:0090161,GO:0099041" "Golgi membrane|inner acrosomal membrane|outer acrosomal membrane|ventricular septum development|chondrocyte differentiation involved in endochondral bone morphogenesis|transcription coactivator activity|protein binding|nucleoplasm|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|cytoskeleton|cilium|transcription by RNA polymerase II|protein glycosylation|nuclear speck|transport vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|intraciliary transport involved in cilium assembly|positive regulation of transcription, DNA-templated|cartilage development|inner ear receptor cell stereocilium organization|Golgi ribbon formation|vesicle tethering to Golgi" TRIP12 6404.136555 6673.214643 6135.058467 0.919355782 -0.121304816 0.617943885 1 22.55460422 20.38872185 9320 thyroid hormone receptor interactor 12 "GO:0000209,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006511,GO:0006974,GO:0016607,GO:0045995,GO:0046966,GO:0061630,GO:1901315,GO:2000779,GO:2000780" protein polyubiquitination|protein binding|nucleus|nucleoplasm|cytosol|DNA repair|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|nuclear speck|regulation of embryonic development|thyroid hormone receptor binding|ubiquitin protein ligase activity|negative regulation of histone H2A K63-linked ubiquitination|regulation of double-strand break repair|negative regulation of double-strand break repair hsa04120 Ubiquitin mediated proteolysis TRIP13 1501.659186 1358.780531 1644.537841 1.210304242 0.275369753 0.248683818 1 22.4437077 26.70916667 9319 thyroid hormone receptor interactor 13 "GO:0001556,GO:0001673,GO:0003712,GO:0005515,GO:0005524,GO:0005634,GO:0005694,GO:0006302,GO:0006355,GO:0006366,GO:0007094,GO:0007130,GO:0007131,GO:0007141,GO:0007144,GO:0007283,GO:0007286,GO:0016887,GO:0042802,GO:0048477,GO:0051598" "oocyte maturation|male germ cell nucleus|transcription coregulator activity|protein binding|ATP binding|nucleus|chromosome|double-strand break repair|regulation of transcription, DNA-templated|transcription by RNA polymerase II|mitotic spindle assembly checkpoint|synaptonemal complex assembly|reciprocal meiotic recombination|male meiosis I|female meiosis I|spermatogenesis|spermatid development|ATPase activity|identical protein binding|oogenesis|meiotic recombination checkpoint" TRIP4 555.2676679 497.3178359 613.2174999 1.233049482 0.302230696 0.258388854 1 13.18476844 15.98542512 9325 thyroid hormone receptor interactor 4 "GO:0002020,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006355,GO:0008270,GO:0016604,GO:0016922,GO:0019901,GO:0030331,GO:0030520,GO:0031594,GO:0032991,GO:0035035,GO:0044389,GO:0045661,GO:0045893,GO:0099053,GO:1901998" "protease binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|regulation of transcription, DNA-templated|zinc ion binding|nuclear body|nuclear receptor binding|protein kinase binding|estrogen receptor binding|intracellular estrogen receptor signaling pathway|neuromuscular junction|protein-containing complex|histone acetyltransferase binding|ubiquitin-like protein ligase binding|regulation of myoblast differentiation|positive regulation of transcription, DNA-templated|activating signal cointegrator 1 complex|toxin transport" TRIP6 1400.608863 1380.629222 1420.588503 1.028942804 0.041162789 0.866372563 1 43.52134915 44.03162998 7205 thyroid hormone receptor interactor 6 "GO:0001725,GO:0003723,GO:0005149,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0007165,GO:0019900,GO:0030335,GO:0043009,GO:0046872,GO:0046966,GO:0048041,GO:1901224" stress fiber|RNA binding|interleukin-1 receptor binding|protein binding|nucleus|cytoplasm|cytosol|cytoskeleton|plasma membrane|focal adhesion|signal transduction|kinase binding|positive regulation of cell migration|chordate embryonic development|metal ion binding|thyroid hormone receptor binding|focal adhesion assembly|positive regulation of NIK/NF-kappaB signaling hsa04621 NOD-like receptor signaling pathway TRIQK 1562.80706 1273.466592 1852.147527 1.454413911 0.540437904 0.023448774 0.846928903 15.68849758 22.435748 286144 triple QxxK/R motif containing "GO:0005789,GO:0016021" endoplasmic reticulum membrane|integral component of membrane TRIR 1711.061008 1582.469515 1839.6525 1.162520024 0.217255567 0.360531614 1 96.07905527 109.8247808 79002 telomerase RNA component interacting RNase "GO:0003723,GO:0005515,GO:0008408,GO:0008409,GO:0016075,GO:0090503" "RNA binding|protein binding|3'-5' exonuclease activity|5'-3' exonuclease activity|rRNA catabolic process|RNA phosphodiester bond hydrolysis, exonucleolytic" TRIT1 555.9212386 564.9447383 546.897739 0.968055284 -0.046838655 0.867224378 1 5.500832395 5.236001364 54802 tRNA isopentenyltransferase 1 "GO:0003676,GO:0005524,GO:0005575,GO:0005739,GO:0005759,GO:0006400,GO:0008270,GO:0052381,GO:0070900" nucleic acid binding|ATP binding|cellular_component|mitochondrion|mitochondrial matrix|tRNA modification|zinc ion binding|tRNA dimethylallyltransferase activity|mitochondrial tRNA modification TRMO 149.6371599 156.0620824 143.2122374 0.917661967 -0.12396528 0.773538228 1 1.982562844 1.78887862 51531 tRNA methyltransferase O "GO:0005515,GO:0016430,GO:0030488" protein binding|tRNA (adenine-N6-)-methyltransferase activity|tRNA methylation TRMT1 512.6295916 563.9043244 461.3548589 0.818143857 -0.289573556 0.287242801 1 12.81163788 10.30636472 55621 tRNA methyltransferase 1 "GO:0000049,GO:0002940,GO:0003723,GO:0004809,GO:0005515,GO:0005634,GO:0005654,GO:0006400,GO:0046872" tRNA binding|tRNA N2-guanine methylation|RNA binding|tRNA (guanine-N2-)-methyltransferase activity|protein binding|nucleus|nucleoplasm|tRNA modification|metal ion binding TRMT10A 64.84784452 74.90979955 54.78588949 0.731358111 -0.451350097 0.415190157 1 1.027183536 0.738668043 93587 tRNA methyltransferase 10A "GO:0000049,GO:0002939,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005739,GO:0005829,GO:0009019,GO:0015629,GO:0030488,GO:0052905,GO:0070062,GO:0090646" tRNA binding|tRNA N1-guanine methylation|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|mitochondrion|cytosol|tRNA (guanine-N1-)-methyltransferase activity|actin cytoskeleton|tRNA methylation|tRNA (guanine(9)-N(1))-methyltransferase activity|extracellular exosome|mitochondrial tRNA processing TRMT10B 273.9672333 303.8008537 244.1336128 0.803597521 -0.315454982 0.333393652 1 2.002382759 1.582183547 158234 tRNA methyltransferase 10B "GO:0000049,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0009019,GO:0030488,GO:0052905,GO:0090646" tRNA binding|protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|tRNA (guanine-N1-)-methyltransferase activity|tRNA methylation|tRNA (guanine(9)-N(1))-methyltransferase activity|mitochondrial tRNA processing TRMT10C 427.3848503 420.3272086 434.4424921 1.033581656 0.04765237 0.874896917 1 12.37291263 12.5744187 54931 "tRNA methyltransferase 10C, mitochondrial RNase P subunit" "GO:0000049,GO:0000964,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0009019,GO:0016429,GO:0030678,GO:0042645,GO:0042802,GO:0052905,GO:0061953,GO:0070131,GO:0070901,GO:0080009,GO:0090646,GO:0097745,GO:1990180" tRNA binding|mitochondrial RNA 5'-end processing|RNA binding|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|tRNA (guanine-N1-)-methyltransferase activity|tRNA (adenine-N1-)-methyltransferase activity|mitochondrial ribonuclease P complex|mitochondrial nucleoid|identical protein binding|tRNA (guanine(9)-N(1))-methyltransferase activity|mRNA (adenine-N1-)-methyltransferase activity|positive regulation of mitochondrial translation|mitochondrial tRNA methylation|mRNA methylation|mitochondrial tRNA processing|mitochondrial tRNA 5'-end processing|mitochondrial tRNA 3'-end processing TRMT11 506.9821572 466.1054194 547.8588949 1.175396964 0.233148077 0.393933253 1 8.928639472 10.31908121 60487 tRNA methyltransferase 11 homolog "GO:0000049,GO:0004809,GO:0005515,GO:0005737,GO:0008168,GO:0030488" tRNA binding|tRNA (guanine-N2-)-methyltransferase activity|protein binding|cytoplasm|methyltransferase activity|tRNA methylation TRMT112 1661.338793 1538.772132 1783.905454 1.159304498 0.213259548 0.369932573 1 83.11886697 94.74762095 51504 tRNA methyltransferase subunit 11-2 "GO:0005515,GO:0005654,GO:0005829,GO:0006415,GO:0008276,GO:0016435,GO:0018364,GO:0030488,GO:0031167,GO:0032259,GO:0032991,GO:0034968,GO:0046982,GO:0048471,GO:0070476,GO:2000234" protein binding|nucleoplasm|cytosol|translational termination|protein methyltransferase activity|rRNA (guanine) methyltransferase activity|peptidyl-glutamine methylation|tRNA methylation|rRNA methylation|methylation|protein-containing complex|histone lysine methylation|protein heterodimerization activity|perinuclear region of cytoplasm|rRNA (guanine-N7)-methylation|positive regulation of rRNA processing TRMT12 254.8088952 242.4164347 267.2013558 1.102241092 0.140439818 0.681162862 1 5.861948154 6.353159364 55039 tRNA methyltransferase 12 homolog "GO:0005515,GO:0005737,GO:0008175,GO:0030488,GO:0102522" protein binding|cytoplasm|tRNA methyltransferase activity|tRNA methylation|tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity TRMT13 426.0022527 472.3479027 379.6566026 0.803764768 -0.315154754 0.268333063 1 5.256117479 4.153987715 54482 tRNA methyltransferase 13 homolog "GO:0008175,GO:0030488,GO:0046872,GO:0106050" tRNA methyltransferase activity|tRNA methylation|metal ion binding|tRNA 2'-O-methyltransferase activity TRMT1L 668.5444478 645.0566072 692.0322883 1.072824122 0.101413581 0.69838745 1 6.109225477 6.444450062 81627 tRNA methyltransferase 1 like "GO:0000049,GO:0002940,GO:0003723,GO:0004809,GO:0005515,GO:0005634,GO:0007610,GO:0046872" tRNA binding|tRNA N2-guanine methylation|RNA binding|tRNA (guanine-N2-)-methyltransferase activity|protein binding|nucleus|behavior|metal ion binding TRMT2A 495.8244537 526.4494246 465.1994827 0.883654651 -0.178445447 0.517624798 1 9.293959054 8.075222568 27037 tRNA methyltransferase 2 homolog A "GO:0001510,GO:0003723,GO:0005515,GO:0006396,GO:0008173" RNA methylation|RNA binding|protein binding|RNA processing|RNA methyltransferase activity TRMT2B 667.6870875 685.6327487 649.7414263 0.947652264 -0.077570329 0.768426392 1 5.898913374 5.496575547 79979 tRNA methyltransferase 2 homolog B "GO:0005515,GO:0030488,GO:0030697" protein binding|tRNA methylation|S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity TRMT44 243.1957658 240.3356069 246.0559247 1.023801375 0.033935849 0.933042316 1 1.85056552 1.862907766 152992 tRNA methyltransferase 44 homolog "GO:0005737,GO:0016300,GO:0030488,GO:0046872" cytoplasm|tRNA (uracil) methyltransferase activity|tRNA methylation|metal ion binding TRMT5 602.427862 637.7737101 567.082014 0.889158655 -0.169487229 0.521485385 1 5.640837045 4.93166982 57570 tRNA methyltransferase 5 "GO:0002939,GO:0005634,GO:0005737,GO:0005759,GO:0008175,GO:0009019,GO:0030488,GO:0052906,GO:0070901" tRNA N1-guanine methylation|nucleus|cytoplasm|mitochondrial matrix|tRNA methyltransferase activity|tRNA (guanine-N1-)-methyltransferase activity|tRNA methylation|tRNA (guanine(37)-N(1))-methyltransferase activity|mitochondrial tRNA methylation TRMT6 646.2346856 652.3395044 640.1298667 0.981283308 -0.027258376 0.922559704 1 11.41447882 11.01340669 51605 tRNA methyltransferase 6 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006400,GO:0016429,GO:0030488,GO:0031515,GO:0080009" RNA binding|protein binding|nucleus|nucleoplasm|tRNA modification|tRNA (adenine-N1-)-methyltransferase activity|tRNA methylation|tRNA (m1A) methyltransferase complex|mRNA methylation TRMT61A 273.803687 312.1241648 235.4832092 0.75445363 -0.406495861 0.211354722 1 5.177958662 3.841159226 115708 tRNA methyltransferase 61A "GO:0005515,GO:0005634,GO:0005654,GO:0006400,GO:0016429,GO:0030488,GO:0031515,GO:0061953,GO:0080009" protein binding|nucleus|nucleoplasm|tRNA modification|tRNA (adenine-N1-)-methyltransferase activity|tRNA methylation|tRNA (m1A) methyltransferase complex|mRNA (adenine-N1-)-methyltransferase activity|mRNA methylation TRMT61B 295.1026035 328.7707869 261.43442 0.7951875 -0.330633017 0.296936739 1 8.089392643 6.32494333 55006 tRNA methyltransferase 61B "GO:0005515,GO:0005739,GO:0005759,GO:0016429,GO:0016433,GO:0030488,GO:0031167,GO:0031515,GO:0051260,GO:0061953,GO:0070901,GO:0080009" protein binding|mitochondrion|mitochondrial matrix|tRNA (adenine-N1-)-methyltransferase activity|rRNA (adenine) methyltransferase activity|tRNA methylation|rRNA methylation|tRNA (m1A) methyltransferase complex|protein homooligomerization|mRNA (adenine-N1-)-methyltransferase activity|mitochondrial tRNA methylation|mRNA methylation TRMT9B 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.013617964 0.004123346 57604 tRNA methyltransferase 9B (putative) "GO:0000049,GO:0002098,GO:0005634,GO:0005737,GO:0006400,GO:0008175,GO:0016300,GO:0016706,GO:0030488,GO:0055114" tRNA binding|tRNA wobble uridine modification|nucleus|cytoplasm|tRNA modification|tRNA methyltransferase activity|tRNA (uracil) methyltransferase activity|2-oxoglutarate-dependent dioxygenase activity|tRNA methylation|oxidation-reduction process TRMU 377.2562856 391.1956199 363.3169514 0.928734712 -0.106661537 0.723374731 1 11.2244039 10.25005374 55687 tRNA mitochondrial 2-thiouridylase "GO:0000049,GO:0002143,GO:0005524,GO:0005739,GO:0016783" tRNA binding|tRNA wobble position uridine thiolation|ATP binding|mitochondrion|sulfurtransferase activity TRNAU1AP 408.0975646 380.791481 435.4036481 1.143417513 0.193352292 0.504964192 1 11.29635435 12.70031011 54952 tRNA selenocysteine 1 associated protein 1 "GO:0000049,GO:0001514,GO:0003723,GO:0005515,GO:0005634,GO:0005737" tRNA binding|selenocysteine incorporation|RNA binding|protein binding|nucleus|cytoplasm TRNP1 611.2072134 615.9250185 606.4894082 0.984680586 -0.022272281 0.938930932 1 16.36991345 15.84940406 388610 TMF1 regulated nuclear protein 1 "GO:0000791,GO:0003677,GO:0005634,GO:0007049,GO:0021696,GO:0042127,GO:0051726,GO:0061351" euchromatin|DNA binding|nucleus|cell cycle|cerebellar cortex morphogenesis|regulation of cell population proliferation|regulation of cell cycle|neural precursor cell proliferation TRNT1 652.7300339 633.6120545 671.8480132 1.060346009 0.084535118 0.748817575 1 6.645973039 6.929108467 51095 tRNA nucleotidyl transferase 1 "GO:0000049,GO:0001680,GO:0005524,GO:0005654,GO:0005739,GO:0005759,GO:0034062,GO:0042780,GO:0052927,GO:0052928,GO:0052929,GO:1990180" tRNA binding|tRNA 3'-terminal CCA addition|ATP binding|nucleoplasm|mitochondrion|mitochondrial matrix|5'-3' RNA polymerase activity|tRNA 3'-end processing|CTP:tRNA cytidylyltransferase activity|CTP:3'-cytidine-tRNA cytidylyltransferase activity|ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity|mitochondrial tRNA 3'-end processing hsa03013 RNA transport TROAP 1143.441123 1227.688382 1059.193864 0.862754653 -0.212977746 0.381492074 1 21.44663585 18.19355913 10024 trophinin associated protein "GO:0005515,GO:0005737,GO:0007155" protein binding|cytoplasm|cell adhesion TRPC1 729.8596698 740.7746844 718.9446551 0.970530811 -0.043154081 0.870625866 1 4.483304992 4.27837443 7220 transient receptor potential cation channel subfamily C member 1 "GO:0005102,GO:0005261,GO:0005262,GO:0005515,GO:0005886,GO:0005887,GO:0006816,GO:0006828,GO:0015279,GO:0034703,GO:0042438,GO:0043235,GO:0051117,GO:0051281,GO:0051480,GO:0051592,GO:0070588,GO:0070679,GO:1903779" "signaling receptor binding|cation channel activity|calcium channel activity|protein binding|plasma membrane|integral component of plasma membrane|calcium ion transport|manganese ion transport|store-operated calcium channel activity|cation channel complex|melanin biosynthetic process|receptor complex|ATPase binding|positive regulation of release of sequestered calcium ion into cytosol|regulation of cytosolic calcium ion concentration|response to calcium ion|calcium ion transmembrane transport|inositol 1,4,5 trisphosphate binding|regulation of cardiac conduction" "hsa04360,hsa04724,hsa04726,hsa04929,hsa04972" Axon guidance|Glutamatergic synapse|Serotonergic synapse|GnRH secretion|Pancreatic secretion TRPC3 5.806564699 1.040413883 10.57271552 10.16202849 3.345116509 0.064182317 1 0.006517016 0.065117899 7222 transient receptor potential cation channel subfamily C member 3 "GO:0005262,GO:0005515,GO:0005886,GO:0005887,GO:0006816,GO:0006828,GO:0007338,GO:0007602,GO:0010524,GO:0015279,GO:0030168,GO:0033198,GO:0034703,GO:0051480,GO:0051592,GO:0070588,GO:0070679,GO:1903244" "calcium channel activity|protein binding|plasma membrane|integral component of plasma membrane|calcium ion transport|manganese ion transport|single fertilization|phototransduction|positive regulation of calcium ion transport into cytosol|store-operated calcium channel activity|platelet activation|response to ATP|cation channel complex|regulation of cytosolic calcium ion concentration|response to calcium ion|calcium ion transmembrane transport|inositol 1,4,5 trisphosphate binding|positive regulation of cardiac muscle hypertrophy in response to stress" "hsa04360,hsa05017,hsa05022" Axon guidance|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases TRPC4 7.084752362 9.363724944 4.80577978 0.513233762 -0.962312016 0.521952192 1 0.062512483 0.031546643 7223 transient receptor potential cation channel subfamily C member 4 "GO:0005515,GO:0005886,GO:0005887,GO:0005901,GO:0005911,GO:0006816,GO:0006828,GO:0008013,GO:0009986,GO:0014051,GO:0015279,GO:0016323,GO:0030863,GO:0034703,GO:0034704,GO:0045296,GO:0048709,GO:0051480,GO:0070509,GO:0070588,GO:0070679" "protein binding|plasma membrane|integral component of plasma membrane|caveola|cell-cell junction|calcium ion transport|manganese ion transport|beta-catenin binding|cell surface|gamma-aminobutyric acid secretion|store-operated calcium channel activity|basolateral plasma membrane|cortical cytoskeleton|cation channel complex|calcium channel complex|cadherin binding|oligodendrocyte differentiation|regulation of cytosolic calcium ion concentration|calcium ion import|calcium ion transmembrane transport|inositol 1,4,5 trisphosphate binding" "hsa04360,hsa04929" Axon guidance|GnRH secretion TRPC4AP 4059.081066 3977.502273 4140.659858 1.041020111 0.05799794 0.808472602 1 60.68381532 62.11595636 26133 transient receptor potential cation channel subfamily C member 4 associated protein "GO:0005515,GO:0005886,GO:0006511,GO:0016567,GO:0019902,GO:0031464,GO:0048820,GO:0070588" protein binding|plasma membrane|ubiquitin-dependent protein catabolic process|protein ubiquitination|phosphatase binding|Cul4A-RING E3 ubiquitin ligase complex|hair follicle maturation|calcium ion transmembrane transport TRPC6 10.00784919 10.40413883 9.61155956 0.923820772 -0.11431511 1 1 0.111294802 0.101095956 7225 transient receptor potential cation channel subfamily C member 6 "GO:0003779,GO:0005261,GO:0005515,GO:0005737,GO:0005886,GO:0005887,GO:0006812,GO:0006828,GO:0007204,GO:0007338,GO:0007568,GO:0010800,GO:0015279,GO:0016020,GO:0030168,GO:0030182,GO:0030276,GO:0032414,GO:0034703,GO:0036057,GO:0042803,GO:0042805,GO:0045666,GO:0050774,GO:0051117,GO:0051480,GO:0051928,GO:0070301,GO:0070588,GO:0070679,GO:0071456" "actin binding|cation channel activity|protein binding|cytoplasm|plasma membrane|integral component of plasma membrane|cation transport|manganese ion transport|positive regulation of cytosolic calcium ion concentration|single fertilization|aging|positive regulation of peptidyl-threonine phosphorylation|store-operated calcium channel activity|membrane|platelet activation|neuron differentiation|clathrin binding|positive regulation of ion transmembrane transporter activity|cation channel complex|slit diaphragm|protein homodimerization activity|actinin binding|positive regulation of neuron differentiation|negative regulation of dendrite morphogenesis|ATPase binding|regulation of cytosolic calcium ion concentration|positive regulation of calcium ion transport|cellular response to hydrogen peroxide|calcium ion transmembrane transport|inositol 1,4,5 trisphosphate binding|cellular response to hypoxia" "hsa04022,hsa04360" cGMP-PKG signaling pathway|Axon guidance TRPM2 489.5624631 462.9841778 516.1407484 1.114812931 0.156801642 0.571876654 1 3.942654322 4.321772261 7226 transient receptor potential cation channel subfamily M member 2 "GO:0001659,GO:0002407,GO:0005261,GO:0005262,GO:0005272,GO:0005509,GO:0005764,GO:0005765,GO:0005886,GO:0005887,GO:0006816,GO:0014074,GO:0015278,GO:0016787,GO:0030659,GO:0035579,GO:0035584,GO:0035725,GO:0042995,GO:0043204,GO:0043312,GO:0047631,GO:0051209,GO:0051289,GO:0051489,GO:0070301,GO:0070588,GO:0070821,GO:0070838,GO:0071277,GO:0071415,GO:0071502,GO:0071577,GO:0072571,GO:0097028,GO:0097553,GO:0098655,GO:0098703,GO:0099604,GO:0101003,GO:2000249" temperature homeostasis|dendritic cell chemotaxis|cation channel activity|calcium channel activity|sodium channel activity|calcium ion binding|lysosome|lysosomal membrane|plasma membrane|integral component of plasma membrane|calcium ion transport|response to purine-containing compound|calcium-release channel activity|hydrolase activity|cytoplasmic vesicle membrane|specific granule membrane|calcium-mediated signaling using intracellular calcium source|sodium ion transmembrane transport|cell projection|perikaryon|neutrophil degranulation|ADP-ribose diphosphatase activity|release of sequestered calcium ion into cytosol|protein homotetramerization|regulation of filopodium assembly|cellular response to hydrogen peroxide|calcium ion transmembrane transport|tertiary granule membrane|divalent metal ion transport|cellular response to calcium ion|cellular response to purine-containing compound|cellular response to temperature stimulus|zinc ion transmembrane transport|mono-ADP-D-ribose binding|dendritic cell differentiation|calcium ion transmembrane import into cytosol|cation transmembrane transport|calcium ion import across plasma membrane|ligand-gated calcium channel activity|ficolin-1-rich granule membrane|regulation of actin cytoskeleton reorganization "hsa04621,hsa04921" NOD-like receptor signaling pathway|Oxytocin signaling pathway TRPM3 3.403674809 1.040413883 5.766935736 5.54292463 2.470647391 0.304382079 1 0.004212821 0.022960594 80036 transient receptor potential cation channel subfamily M member 3 "GO:0005227,GO:0005261,GO:0005262,GO:0005886,GO:0005887,GO:0006812,GO:0016048,GO:0050951,GO:0051262,GO:0070588,GO:0070838,GO:0098655" calcium activated cation channel activity|cation channel activity|calcium channel activity|plasma membrane|integral component of plasma membrane|cation transport|detection of temperature stimulus|sensory perception of temperature stimulus|protein tetramerization|calcium ion transmembrane transport|divalent metal ion transport|cation transmembrane transport TRPM4 433.6870843 383.9127227 483.4614459 1.259300402 0.332622474 0.240582469 1 5.0427557 6.244079867 54795 transient receptor potential cation channel subfamily M member 4 "GO:0002250,GO:0002407,GO:0002724,GO:0005227,GO:0005261,GO:0005509,GO:0005515,GO:0005516,GO:0005524,GO:0005654,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0005887,GO:0007204,GO:0008284,GO:0010460,GO:0016925,GO:0019722,GO:0030502,GO:0034706,GO:0035774,GO:0042310,GO:0043025,GO:0044214,GO:0045600,GO:0045668,GO:0045907,GO:0051289,GO:0070588,GO:0070838,GO:0071318,GO:0086045,GO:0086047,GO:0086048,GO:0086091,GO:0089717,GO:0090263,GO:0098655,GO:0098662,GO:0098719,GO:0098911,GO:0099604,GO:1903949,GO:1904179,GO:1904199" adaptive immune response|dendritic cell chemotaxis|regulation of T cell cytokine production|calcium activated cation channel activity|cation channel activity|calcium ion binding|protein binding|calmodulin binding|ATP binding|nucleoplasm|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|integral component of plasma membrane|positive regulation of cytosolic calcium ion concentration|positive regulation of cell population proliferation|positive regulation of heart rate|protein sumoylation|calcium-mediated signaling|negative regulation of bone mineralization|sodium channel complex|positive regulation of insulin secretion involved in cellular response to glucose stimulus|vasoconstriction|neuronal cell body|spanning component of plasma membrane|positive regulation of fat cell differentiation|negative regulation of osteoblast differentiation|positive regulation of vasoconstriction|protein homotetramerization|calcium ion transmembrane transport|divalent metal ion transport|cellular response to ATP|membrane depolarization during AV node cell action potential|membrane depolarization during Purkinje myocyte cell action potential|membrane depolarization during bundle of His cell action potential|regulation of heart rate by cardiac conduction|spanning component of membrane|positive regulation of canonical Wnt signaling pathway|cation transmembrane transport|inorganic cation transmembrane transport|sodium ion import across plasma membrane|regulation of ventricular cardiac muscle cell action potential|ligand-gated calcium channel activity|positive regulation of atrial cardiac muscle cell action potential|positive regulation of adipose tissue development|positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization hsa04911 Insulin secretion TRPM6 30.66767183 22.88910542 38.44623824 1.67967413 0.748181366 0.306316637 1 0.144408262 0.238499928 140803 transient receptor potential cation channel subfamily M member 6 "GO:0005261,GO:0005262,GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0006468,GO:0009636,GO:0016324,GO:0031526,GO:0046872,GO:0051262,GO:0070588,GO:0070838,GO:0098655,GO:0106310,GO:0106311" cation channel activity|calcium channel activity|protein binding|ATP binding|plasma membrane|integral component of plasma membrane|protein phosphorylation|response to toxic substance|apical plasma membrane|brush border membrane|metal ion binding|protein tetramerization|calcium ion transmembrane transport|divalent metal ion transport|cation transmembrane transport|protein serine kinase activity|protein threonine kinase activity hsa04978 Mineral absorption TRPM7 1487.061366 1707.319181 1266.80355 0.74198402 -0.430539978 0.071353194 1 8.575669345 6.256533268 54822 transient receptor potential cation channel subfamily M member 7 "GO:0001726,GO:0003779,GO:0005261,GO:0005262,GO:0005524,GO:0005886,GO:0005887,GO:0006816,GO:0010961,GO:0016340,GO:0017022,GO:0031032,GO:0046777,GO:0046872,GO:0051262,GO:0070266,GO:0070588,GO:0070838,GO:0072507,GO:0098655,GO:0106310,GO:0106311" ruffle|actin binding|cation channel activity|calcium channel activity|ATP binding|plasma membrane|integral component of plasma membrane|calcium ion transport|cellular magnesium ion homeostasis|calcium-dependent cell-matrix adhesion|myosin binding|actomyosin structure organization|protein autophosphorylation|metal ion binding|protein tetramerization|necroptotic process|calcium ion transmembrane transport|divalent metal ion transport|divalent inorganic cation homeostasis|cation transmembrane transport|protein serine kinase activity|protein threonine kinase activity "hsa04217,hsa04218,hsa04621,hsa04978" Necroptosis|Cellular senescence|NOD-like receptor signaling pathway|Mineral absorption TRPS1 519.2192891 509.8028025 528.6357758 1.036941683 0.052334759 0.853598363 1 2.692719576 2.745469596 7227 transcriptional repressor GATA binding 1 "GO:0000122,GO:0000785,GO:0000977,GO:0001227,GO:0001501,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008270,GO:0019904,GO:0032330,GO:0032991" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|skeletal system development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|zinc ion binding|protein domain specific binding|regulation of chondrocyte differentiation|protein-containing complex" TRPT1 402.1274536 388.0743782 416.1805289 1.072424649 0.100876285 0.733464538 1 20.24517724 21.34811577 83707 tRNA phosphotransferase 1 "GO:0000215,GO:0003674,GO:0003950,GO:0006388,GO:0008033,GO:0008150,GO:0045859" "tRNA 2'-phosphotransferase activity|molecular_function|NAD+ ADP-ribosyltransferase activity|tRNA splicing, via endonucleolytic cleavage and ligation|tRNA processing|biological_process|regulation of protein kinase activity" TRPV1 76.05965387 79.07145508 73.04785266 0.923820772 -0.11431511 0.848081344 1 0.852332505 0.774226358 7442 transient receptor potential cation channel subfamily V member 1 "GO:0004888,GO:0005216,GO:0005230,GO:0005231,GO:0005262,GO:0005515,GO:0005516,GO:0005524,GO:0005886,GO:0005887,GO:0007166,GO:0007635,GO:0015278,GO:0016021,GO:0031226,GO:0032591,GO:0034605,GO:0035091,GO:0045211,GO:0046872,GO:0050955,GO:0051209,GO:0051219,GO:0051289,GO:0060079,GO:0070588,GO:0071312,GO:0071318,GO:0071468,GO:0098703,GO:1901594" transmembrane signaling receptor activity|ion channel activity|extracellular ligand-gated ion channel activity|excitatory extracellular ligand-gated ion channel activity|calcium channel activity|protein binding|calmodulin binding|ATP binding|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|chemosensory behavior|calcium-release channel activity|integral component of membrane|intrinsic component of plasma membrane|dendritic spine membrane|cellular response to heat|phosphatidylinositol binding|postsynaptic membrane|metal ion binding|thermoception|release of sequestered calcium ion into cytosol|phosphoprotein binding|protein homotetramerization|excitatory postsynaptic potential|calcium ion transmembrane transport|cellular response to alkaloid|cellular response to ATP|cellular response to acidic pH|calcium ion import across plasma membrane|response to capsazepine "hsa04080,hsa04750" Neuroactive ligand-receptor interaction|Inflammatory mediator regulation of TRP channels TRPV2 1160.831863 1103.879129 1217.784596 1.103186539 0.141676758 0.561092556 1 17.58042384 19.06994646 51393 transient receptor potential cation channel subfamily V member 2 "GO:0005216,GO:0005261,GO:0005262,GO:0005886,GO:0005887,GO:0007600,GO:0009266,GO:0009408,GO:0009986,GO:0015075,GO:0032584,GO:0042470,GO:0044295,GO:0044297,GO:0045773,GO:0070588,GO:0090280,GO:0098703,GO:0120162" ion channel activity|cation channel activity|calcium channel activity|plasma membrane|integral component of plasma membrane|sensory perception|response to temperature stimulus|response to heat|cell surface|ion transmembrane transporter activity|growth cone membrane|melanosome|axonal growth cone|cell body|positive regulation of axon extension|calcium ion transmembrane transport|positive regulation of calcium ion import|calcium ion import across plasma membrane|positive regulation of cold-induced thermogenesis "hsa04621,hsa04750" NOD-like receptor signaling pathway|Inflammatory mediator regulation of TRP channels TRPV3 33.63542804 12.48496659 54.78588949 4.388148666 2.133612404 0.003484764 0.377418567 0.11236083 0.4848054 162514 transient receptor potential cation channel subfamily V member 3 "GO:0005216,GO:0005262,GO:0005886,GO:0005887,GO:0009408,GO:0042636,GO:0043235,GO:0070588,GO:0090280,GO:0098703" ion channel activity|calcium channel activity|plasma membrane|integral component of plasma membrane|response to heat|negative regulation of hair cycle|receptor complex|calcium ion transmembrane transport|positive regulation of calcium ion import|calcium ion import across plasma membrane hsa04750 Inflammatory mediator regulation of TRP channels TRPV4 121.040255 162.3045657 79.77594435 0.491520026 -1.024677897 0.019522889 0.80560651 1.522569233 0.735850256 59341 transient receptor potential cation channel subfamily V member 4 "GO:0003779,GO:0005080,GO:0005216,GO:0005261,GO:0005262,GO:0005515,GO:0005516,GO:0005524,GO:0005783,GO:0005881,GO:0005886,GO:0005887,GO:0005912,GO:0005925,GO:0005929,GO:0006816,GO:0006874,GO:0006884,GO:0007015,GO:0007043,GO:0007204,GO:0007231,GO:0008017,GO:0008289,GO:0009612,GO:0010977,GO:0015275,GO:0016021,GO:0016324,GO:0019901,GO:0030027,GO:0030175,GO:0030426,GO:0030864,GO:0031117,GO:0031532,GO:0032587,GO:0034605,GO:0042169,GO:0042802,GO:0043014,GO:0043117,GO:0043622,GO:0046785,GO:0046872,GO:0048487,GO:0050891,GO:0051015,GO:0060351,GO:0070509,GO:0070588,GO:0071470,GO:0071476,GO:0097497,GO:0098703,GO:1902656" "actin binding|protein kinase C binding|ion channel activity|cation channel activity|calcium channel activity|protein binding|calmodulin binding|ATP binding|endoplasmic reticulum|cytoplasmic microtubule|plasma membrane|integral component of plasma membrane|adherens junction|focal adhesion|cilium|calcium ion transport|cellular calcium ion homeostasis|cell volume homeostasis|actin filament organization|cell-cell junction assembly|positive regulation of cytosolic calcium ion concentration|osmosensory signaling pathway|microtubule binding|lipid binding|response to mechanical stimulus|negative regulation of neuron projection development|stretch-activated, cation-selective, calcium channel activity|integral component of membrane|apical plasma membrane|protein kinase binding|lamellipodium|filopodium|growth cone|cortical actin cytoskeleton|positive regulation of microtubule depolymerization|actin cytoskeleton reorganization|ruffle membrane|cellular response to heat|SH2 domain binding|identical protein binding|alpha-tubulin binding|positive regulation of vascular permeability|cortical microtubule organization|microtubule polymerization|metal ion binding|beta-tubulin binding|multicellular organismal water homeostasis|actin filament binding|cartilage development involved in endochondral bone morphogenesis|calcium ion import|calcium ion transmembrane transport|cellular response to osmotic stress|cellular hypotonic response|blood vessel endothelial cell delamination|calcium ion import across plasma membrane|calcium ion import into cytosol" "hsa04218,hsa04750,hsa05418" Cellular senescence|Inflammatory mediator regulation of TRP channels|Fluid shear stress and atherosclerosis TRRAP 3199.379211 3549.892168 2848.866254 0.802521913 -0.317387309 0.18047249 1 14.94684186 11.79444523 8295 transformation/transcription domain associated protein "GO:0000124,GO:0000125,GO:0000812,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0006281,GO:0006355,GO:0016301,GO:0016310,GO:0016573,GO:0016578,GO:0016579,GO:0030914,GO:0033276,GO:0035267,GO:0043967,GO:0043968,GO:1904837" "SAGA complex|PCAF complex|Swr1 complex|transcription coregulator activity|protein binding|nucleus|nucleoplasm|Golgi apparatus|DNA repair|regulation of transcription, DNA-templated|kinase activity|phosphorylation|histone acetylation|histone deubiquitination|protein deubiquitination|STAGA complex|transcription factor TFTC complex|NuA4 histone acetyltransferase complex|histone H4 acetylation|histone H2A acetylation|beta-catenin-TCF complex assembly" hsa05166 Human T-cell leukemia virus 1 infection other TRUB1 603.934377 576.389291 631.4794631 1.095578063 0.131692284 0.619741115 1 9.031367323 9.728995726 142940 TruB pseudouridine synthase family member 1 "GO:0003723,GO:0005634,GO:0005739,GO:0005829,GO:0006400,GO:0009982,GO:1990481" RNA binding|nucleus|mitochondrion|cytosol|tRNA modification|pseudouridine synthase activity|mRNA pseudouridine synthesis TRUB2 644.7086633 662.7436432 626.6736833 0.945574793 -0.080736518 0.760527087 1 6.031618378 5.607908523 26995 TruB pseudouridine synthase family member 2 "GO:0001522,GO:0003723,GO:0005759,GO:0006397,GO:0009982,GO:0070131" pseudouridine synthesis|RNA binding|mitochondrial matrix|mRNA processing|pseudouridine synthase activity|positive regulation of mitochondrial translation TSACC 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.176971131 128229 TSSK6 activating cochaperone "GO:0005515,GO:0005737,GO:0051087" protein binding|cytoplasm|chaperone binding TSC1 949.4373032 1054.979677 843.8949294 0.799915816 -0.322079917 0.192251885 1 6.260683464 4.924217295 7248 TSC complex subunit 1 "GO:0001822,GO:0001843,GO:0001952,GO:0002250,GO:0005515,GO:0005634,GO:0005737,GO:0005811,GO:0005829,GO:0005884,GO:0005886,GO:0005938,GO:0006407,GO:0006417,GO:0006813,GO:0007160,GO:0008285,GO:0008344,GO:0010977,GO:0014069,GO:0016020,GO:0016239,GO:0016242,GO:0017148,GO:0021766,GO:0021987,GO:0030027,GO:0030030,GO:0030426,GO:0030544,GO:0032007,GO:0032780,GO:0032794,GO:0032868,GO:0032991,GO:0033596,GO:0034260,GO:0042030,GO:0042552,GO:0043379,GO:0043666,GO:0044877,GO:0045792,GO:0045859,GO:0046323,GO:0046627,GO:0047485,GO:0048471,GO:0050808,GO:0050821,GO:0051087,GO:0051492,GO:0051496,GO:0051726,GO:0051879,GO:0051894,GO:0055007,GO:0090630,GO:0090650,GO:0101031,GO:1901214,GO:1903204" kidney development|neural tube closure|regulation of cell-matrix adhesion|adaptive immune response|protein binding|nucleus|cytoplasm|lipid droplet|cytosol|actin filament|plasma membrane|cell cortex|rRNA export from nucleus|regulation of translation|potassium ion transport|cell-matrix adhesion|negative regulation of cell population proliferation|adult locomotory behavior|negative regulation of neuron projection development|postsynaptic density|membrane|positive regulation of macroautophagy|negative regulation of macroautophagy|negative regulation of translation|hippocampus development|cerebral cortex development|lamellipodium|cell projection organization|growth cone|Hsp70 protein binding|negative regulation of TOR signaling|negative regulation of ATPase activity|GTPase activating protein binding|response to insulin|protein-containing complex|TSC1-TSC2 complex|negative regulation of GTPase activity|ATPase inhibitor activity|myelination|memory T cell differentiation|regulation of phosphoprotein phosphatase activity|protein-containing complex binding|negative regulation of cell size|regulation of protein kinase activity|glucose import|negative regulation of insulin receptor signaling pathway|protein N-terminus binding|perinuclear region of cytoplasm|synapse organization|protein stabilization|chaperone binding|regulation of stress fiber assembly|positive regulation of stress fiber assembly|regulation of cell cycle|Hsp90 protein binding|positive regulation of focal adhesion assembly|cardiac muscle cell differentiation|activation of GTPase activity|cellular response to oxygen-glucose deprivation|chaperone complex|regulation of neuron death|negative regulation of oxidative stress-induced neuron death "hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04218,hsa04714,hsa04910,hsa05163,hsa05165,hsa05168,hsa05231" Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Cellular senescence|Thermogenesis|Insulin signaling pathway|Human cytomegalovirus infection|Human papillomavirus infection|Herpes simplex virus 1 infection|Choline metabolism in cancer TSC2 1122.32526 1253.698729 990.9517906 0.790422586 -0.339303924 0.163274491 1 9.826347032 7.636996961 7249 TSC complex subunit 2 "GO:0001843,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005794,GO:0005829,GO:0006469,GO:0006606,GO:0006897,GO:0007507,GO:0008104,GO:0008285,GO:0014067,GO:0014069,GO:0016020,GO:0016032,GO:0016192,GO:0016239,GO:0019902,GO:0030100,GO:0030178,GO:0031267,GO:0032007,GO:0033596,GO:0042803,GO:0043276,GO:0043491,GO:0043547,GO:0046626,GO:0046627,GO:0048009,GO:0048471,GO:0050918,GO:0051056,GO:0051726,GO:0051879,GO:0051898,GO:1901525" neural tube closure|GTPase activator activity|protein binding|nucleus|cytoplasm|lysosome|Golgi apparatus|cytosol|negative regulation of protein kinase activity|protein import into nucleus|endocytosis|heart development|protein localization|negative regulation of cell population proliferation|negative regulation of phosphatidylinositol 3-kinase signaling|postsynaptic density|membrane|viral process|vesicle-mediated transport|positive regulation of macroautophagy|phosphatase binding|regulation of endocytosis|negative regulation of Wnt signaling pathway|small GTPase binding|negative regulation of TOR signaling|TSC1-TSC2 complex|protein homodimerization activity|anoikis|protein kinase B signaling|positive regulation of GTPase activity|regulation of insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|perinuclear region of cytoplasm|positive chemotaxis|regulation of small GTPase mediated signal transduction|regulation of cell cycle|Hsp90 protein binding|negative regulation of protein kinase B signaling|negative regulation of mitophagy "hsa04072,hsa04115,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04218,hsa04714,hsa04910,hsa04919,hsa05163,hsa05165,hsa05168,hsa05231" Phospholipase D signaling pathway|p53 signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Cellular senescence|Thermogenesis|Insulin signaling pathway|Thyroid hormone signaling pathway|Human cytomegalovirus infection|Human papillomavirus infection|Herpes simplex virus 1 infection|Choline metabolism in cancer TSC22D1 3175.459752 3477.063196 2873.856308 0.826518285 -0.274881359 0.245997509 1 16.62317228 13.50944633 8848 TSC22 domain family member 1 "GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0006366" protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II TSC22D2 789.635007 682.511507 896.7585069 1.313909726 0.393866156 0.118147192 1 3.191761718 4.123511095 9819 TSC22 domain family member 2 "GO:0006357,GO:0006970" regulation of transcription by RNA polymerase II|response to osmotic stress TSC22D3 240.2179488 275.7096789 204.7262186 0.742542734 -0.429454039 0.206416514 1 4.272392227 3.11934742 1831 TSC22 domain family member 3 "GO:0005515,GO:0005634,GO:0005829,GO:0006357,GO:0006970,GO:0034220,GO:0070236" protein binding|nucleus|cytosol|regulation of transcription by RNA polymerase II|response to osmotic stress|ion transmembrane transport|negative regulation of activation-induced cell death of T cells TSC22D4 1039.305999 954.0595304 1124.552469 1.17870262 0.237199781 0.333523928 1 21.96566163 25.45773238 81628 TSC22 domain family member 4 "GO:0005515,GO:0005634,GO:0006357,GO:0006970,GO:0045892" "protein binding|nucleus|regulation of transcription by RNA polymerase II|response to osmotic stress|negative regulation of transcription, DNA-templated" TSC22 TSEN15 1115.850033 1222.486312 1009.213754 0.825541966 -0.276586539 0.256197613 1 18.12777095 14.71481272 116461 tRNA splicing endonuclease subunit 15 "GO:0003676,GO:0004518,GO:0005515,GO:0005654,GO:0005730,GO:0006388,GO:0006397,GO:0090305" "nucleic acid binding|nuclease activity|protein binding|nucleoplasm|nucleolus|tRNA splicing, via endonucleolytic cleavage and ligation|mRNA processing|nucleic acid phosphodiester bond hydrolysis" TSEN2 211.9978262 241.3760208 182.6196316 0.756577356 -0.402440497 0.258593755 1 3.135782522 2.33276211 80746 tRNA splicing endonuclease subunit 2 "GO:0000213,GO:0000214,GO:0000379,GO:0003676,GO:0005515,GO:0005654,GO:0005730,GO:0005813,GO:0005829,GO:0006388,GO:0006397,GO:0016829,GO:0090502" "tRNA-intron endonuclease activity|tRNA-intron endonuclease complex|tRNA-type intron splice site recognition and cleavage|nucleic acid binding|protein binding|nucleoplasm|nucleolus|centrosome|cytosol|tRNA splicing, via endonucleolytic cleavage and ligation|mRNA processing|lyase activity|RNA phosphodiester bond hydrolysis, endonucleolytic" TSEN34 946.8028987 834.4119339 1059.193864 1.269389639 0.344134972 0.163765315 1 16.56660392 20.67757557 79042 tRNA splicing endonuclease subunit 34 "GO:0000213,GO:0000214,GO:0000379,GO:0003676,GO:0005654,GO:0005730,GO:0006388,GO:0006397,GO:0016829,GO:0090502" "tRNA-intron endonuclease activity|tRNA-intron endonuclease complex|tRNA-type intron splice site recognition and cleavage|nucleic acid binding|nucleoplasm|nucleolus|tRNA splicing, via endonucleolytic cleavage and ligation|mRNA processing|lyase activity|RNA phosphodiester bond hydrolysis, endonucleolytic" TSEN54 388.7951875 378.7106533 398.8797217 1.053257199 0.074857776 0.80506503 1 10.43422381 10.80601989 283989 tRNA splicing endonuclease subunit 54 "GO:0000214,GO:0000379,GO:0005515,GO:0005654,GO:0005730,GO:0006388,GO:0006397" "tRNA-intron endonuclease complex|tRNA-type intron splice site recognition and cleavage|protein binding|nucleoplasm|nucleolus|tRNA splicing, via endonucleolytic cleavage and ligation|mRNA processing" TSFM 494.3286139 461.9437639 526.7134639 1.140211223 0.189301107 0.492583302 1 10.4373792 11.70167284 10102 "Ts translation elongation factor, mitochondrial" "GO:0003723,GO:0003746,GO:0005515,GO:0005654,GO:0005739,GO:0005759,GO:0006414,GO:0032784,GO:0070125,GO:0070129" "RNA binding|translation elongation factor activity|protein binding|nucleoplasm|mitochondrion|mitochondrial matrix|translational elongation|regulation of DNA-templated transcription, elongation|mitochondrial translational elongation|regulation of mitochondrial translation" TSG101 2670.135637 2474.104213 2866.167061 1.158466586 0.212216433 0.36968173 1 83.88716305 95.55429173 7251 tumor susceptibility 101 "GO:0000122,GO:0000813,GO:0001558,GO:0003677,GO:0003714,GO:0005515,GO:0005730,GO:0005737,GO:0005768,GO:0005769,GO:0005770,GO:0005771,GO:0005815,GO:0005829,GO:0005886,GO:0006513,GO:0006858,GO:0007050,GO:0007175,GO:0008285,GO:0008333,GO:0010008,GO:0015031,GO:0016197,GO:0016236,GO:0019058,GO:0030216,GO:0030374,GO:0031625,GO:0031901,GO:0031902,GO:0036258,GO:0039702,GO:0042059,GO:0042803,GO:0043130,GO:0043162,GO:0043405,GO:0043657,GO:0044877,GO:0045893,GO:0046755,GO:0046790,GO:0048306,GO:0051301,GO:0070062,GO:0075733,GO:0090543,GO:0097352,GO:1902186,GO:1902188,GO:1903543,GO:1903551,GO:1903774,GO:1990182,GO:2000397" "negative regulation of transcription by RNA polymerase II|ESCRT I complex|regulation of cell growth|DNA binding|transcription corepressor activity|protein binding|nucleolus|cytoplasm|endosome|early endosome|late endosome|multivesicular body|microtubule organizing center|cytosol|plasma membrane|protein monoubiquitination|extracellular transport|cell cycle arrest|negative regulation of epidermal growth factor-activated receptor activity|negative regulation of cell population proliferation|endosome to lysosome transport|endosome membrane|protein transport|endosomal transport|macroautophagy|viral life cycle|keratinocyte differentiation|nuclear receptor coactivator activity|ubiquitin protein ligase binding|early endosome membrane|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|negative regulation of epidermal growth factor receptor signaling pathway|protein homodimerization activity|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|regulation of MAP kinase activity|host cell|protein-containing complex binding|positive regulation of transcription, DNA-templated|viral budding|virion binding|calcium-dependent protein binding|cell division|extracellular exosome|intracellular transport of virus|Flemming body|autophagosome maturation|regulation of viral release from host cell|positive regulation of viral release from host cell|positive regulation of exosomal secretion|regulation of extracellular exosome assembly|positive regulation of viral budding via host ESCRT complex|exosomal secretion|positive regulation of ubiquitin-dependent endocytosis" hsa04144 Endocytosis TSGA10 70.97144093 84.27352449 57.66935736 0.684311683 -0.547274517 0.303263119 1 0.675811137 0.454726723 80705 testis specific 10 "GO:0003674,GO:0005515,GO:0005575,GO:0005737,GO:0005814,GO:0007283" molecular_function|protein binding|cellular_component|cytoplasm|centriole|spermatogenesis TSHZ1 610.4687399 659.6224016 561.3150783 0.850964244 -0.232829581 0.375594464 1 6.170523267 5.163028056 10194 teashirt zinc finger homeobox 1 "GO:0000785,GO:0000981,GO:0003677,GO:0005634,GO:0006357,GO:0009952,GO:0042474,GO:0046872,GO:0060023" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|middle ear morphogenesis|metal ion binding|soft palate development" TSKU 718.0087666 732.4513734 703.5661598 0.960563643 -0.05804689 0.824982172 1 10.32477116 9.7516422 25987 "tsukushi, small leucine rich proteoglycan" "GO:0003431,GO:0005615,GO:0008203,GO:0010468,GO:0010977,GO:0021540,GO:0021670,GO:0021766,GO:0021960,GO:0030178,GO:0032911,GO:0033344,GO:0042060,GO:0042632,GO:0042635,GO:0043010,GO:0050431,GO:0060122,GO:0061073,GO:0097009,GO:0098868,GO:1904761" growth plate cartilage chondrocyte development|extracellular space|cholesterol metabolic process|regulation of gene expression|negative regulation of neuron projection development|corpus callosum morphogenesis|lateral ventricle development|hippocampus development|anterior commissure morphogenesis|negative regulation of Wnt signaling pathway|negative regulation of transforming growth factor beta1 production|cholesterol efflux|wound healing|cholesterol homeostasis|positive regulation of hair cycle|camera-type eye development|transforming growth factor beta binding|inner ear receptor cell stereocilium organization|ciliary body morphogenesis|energy homeostasis|bone growth|negative regulation of myofibroblast differentiation TSLP 10.40916924 8.323311061 12.49502743 1.501208754 0.586124608 0.656643747 1 0.160592847 0.237049183 85480 thymic stromal lymphopoietin "GO:0001961,GO:0005125,GO:0005139,GO:0005576,GO:0005615,GO:0008284,GO:0032722,GO:0032733,GO:0032736,GO:0032754,GO:0032755,GO:0033005,GO:0038111,GO:0042531,GO:0043066,GO:0050729,GO:0071654,GO:0071657,GO:1904894" positive regulation of cytokine-mediated signaling pathway|cytokine activity|interleukin-7 receptor binding|extracellular region|extracellular space|positive regulation of cell population proliferation|positive regulation of chemokine production|positive regulation of interleukin-10 production|positive regulation of interleukin-13 production|positive regulation of interleukin-5 production|positive regulation of interleukin-6 production|positive regulation of mast cell activation|interleukin-7-mediated signaling pathway|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of apoptotic process|positive regulation of inflammatory response|positive regulation of chemokine (C-C motif) ligand 1 production|positive regulation of granulocyte colony-stimulating factor production|positive regulation of receptor signaling pathway via STAT "hsa04060,hsa04630" Cytokine-cytokine receptor interaction|JAK-STAT signaling pathway TSN 1983.076361 1860.260022 2105.8927 1.13204212 0.178927638 0.450120782 1 30.06621998 33.46667724 7247 translin "GO:0003677,GO:0003697,GO:0003723,GO:0004521,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0006310,GO:0030422,GO:0042802,GO:0043565,GO:0044877,GO:0090502" "DNA binding|single-stranded DNA binding|RNA binding|endoribonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|DNA recombination|production of siRNA involved in RNA interference|identical protein binding|sequence-specific DNA binding|protein-containing complex binding|RNA phosphodiester bond hydrolysis, endonucleolytic" TSNARE1 501.1900693 528.5302524 473.8498863 0.896542599 -0.15755596 0.567618536 1 2.283018063 2.012572139 203062 t-SNARE domain containing 1 "GO:0000149,GO:0005484,GO:0006886,GO:0006906,GO:0012505,GO:0016021,GO:0031201,GO:0048278" SNARE binding|SNAP receptor activity|intracellular protein transport|vesicle fusion|endomembrane system|integral component of membrane|SNARE complex|vesicle docking TSNAX 801.9904115 830.2502783 773.7305446 0.931924463 -0.101715073 0.689270865 1 16.82191778 15.41442739 7257 translin associated factor X "GO:0003677,GO:0003723,GO:0004521,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0007275,GO:0007283,GO:0030154,GO:0030422,GO:0043565,GO:0046872,GO:0048471,GO:0090502" "DNA binding|RNA binding|endoribonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|multicellular organism development|spermatogenesis|cell differentiation|production of siRNA involved in RNA interference|sequence-specific DNA binding|metal ion binding|perinuclear region of cytoplasm|RNA phosphodiester bond hydrolysis, endonucleolytic" TSNAXIP1 10.85011826 7.282897178 14.41733934 1.979615939 0.985220564 0.397526524 1 0.126357229 0.245953051 55815 translin associated factor X interacting protein 1 "GO:0003674,GO:0005515,GO:0005575,GO:0005737,GO:0007275,GO:0007283,GO:0008150,GO:0030154,GO:0048471" molecular_function|protein binding|cellular_component|cytoplasm|multicellular organism development|spermatogenesis|biological_process|cell differentiation|perinuclear region of cytoplasm TSPAN1 91.83946922 76.99062732 106.6883111 1.385731158 0.470647391 0.333133641 1 2.154613674 2.935753399 10103 tetraspanin 1 "GO:0005515,GO:0005654,GO:0005737,GO:0005765,GO:0005886,GO:0005887,GO:0016020,GO:0030054,GO:0031982,GO:0043231,GO:0048471,GO:0050821,GO:0070062" protein binding|nucleoplasm|cytoplasm|lysosomal membrane|plasma membrane|integral component of plasma membrane|membrane|cell junction|vesicle|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|protein stabilization|extracellular exosome TSPAN10 30.5884139 20.80827765 40.36855015 1.940023621 0.956074218 0.188460412 1 0.588500018 1.122599067 83882 tetraspanin 10 "GO:0005887,GO:0019899,GO:0072594" integral component of plasma membrane|enzyme binding|establishment of protein localization to organelle TSPAN12 170.1334363 176.87036 163.3965125 0.923820772 -0.11431511 0.780116807 1 3.313178674 3.009565216 23554 tetraspanin 12 "GO:0001525,GO:0005515,GO:0005887,GO:0007166,GO:0010842,GO:0016020,GO:0016021,GO:0016055,GO:0042813,GO:0045765,GO:1900746" angiogenesis|protein binding|integral component of plasma membrane|cell surface receptor signaling pathway|retina layer formation|membrane|integral component of membrane|Wnt signaling pathway|Wnt-activated receptor activity|regulation of angiogenesis|regulation of vascular endothelial growth factor signaling pathway TSPAN13 643.1140583 545.1768745 741.0512421 1.359285907 0.442848938 0.088174046 1 15.53394971 20.76174666 27075 tetraspanin 13 "GO:0005246,GO:0005887,GO:0016020,GO:1903169" calcium channel regulator activity|integral component of plasma membrane|membrane|regulation of calcium ion transmembrane transport TSPAN14 3884.404161 3845.36971 3923.438612 1.020302054 0.028996316 0.904063667 1 44.55499651 44.69885036 81619 tetraspanin 14 "GO:0005515,GO:0005788,GO:0005886,GO:0005887,GO:0009986,GO:0019899,GO:0035579,GO:0043312,GO:0044267,GO:0045747,GO:0051604,GO:0070821,GO:0072659,GO:0097197" protein binding|endoplasmic reticulum lumen|plasma membrane|integral component of plasma membrane|cell surface|enzyme binding|specific granule membrane|neutrophil degranulation|cellular protein metabolic process|positive regulation of Notch signaling pathway|protein maturation|tertiary granule membrane|protein localization to plasma membrane|tetraspanin-enriched microdomain TSPAN15 532.5861538 532.6919079 532.4803996 0.999602944 -0.000572944 1 1 2.940503525 2.890150175 23555 tetraspanin 15 "GO:0005515,GO:0005788,GO:0005829,GO:0005886,GO:0005887,GO:0008593,GO:0009986,GO:0016604,GO:0019899,GO:0030054,GO:0031902,GO:0043231,GO:0044267,GO:0045746,GO:0051604,GO:0072659,GO:0097197" protein binding|endoplasmic reticulum lumen|cytosol|plasma membrane|integral component of plasma membrane|regulation of Notch signaling pathway|cell surface|nuclear body|enzyme binding|cell junction|late endosome membrane|intracellular membrane-bounded organelle|cellular protein metabolic process|negative regulation of Notch signaling pathway|protein maturation|protein localization to plasma membrane|tetraspanin-enriched microdomain TSPAN17 1120.879724 1064.343402 1177.416046 1.106236995 0.145660494 0.551231398 1 22.95032371 24.96365501 26262 tetraspanin 17 "GO:0000151,GO:0004842,GO:0005887,GO:0016567,GO:0019899,GO:0051604,GO:0072594,GO:0072659" ubiquitin ligase complex|ubiquitin-protein transferase activity|integral component of plasma membrane|protein ubiquitination|enzyme binding|protein maturation|establishment of protein localization to organelle|protein localization to plasma membrane TSPAN2 320.3700611 336.0536841 304.686438 0.906660014 -0.141366434 0.652979948 1 5.580139228 4.974628761 10100 tetraspanin 2 "GO:0005515,GO:0005654,GO:0005887,GO:0006954,GO:0007420,GO:0014002,GO:0014005,GO:0016021,GO:0042552,GO:0043209,GO:0048709,GO:0061564" protein binding|nucleoplasm|integral component of plasma membrane|inflammatory response|brain development|astrocyte development|microglia development|integral component of membrane|myelination|myelin sheath|oligodendrocyte differentiation|axon development TSPAN3 2606.045773 2406.477311 2805.614236 1.165859418 0.221393835 0.349248651 1 20.40503196 23.3913153 10099 tetraspanin 3 "GO:0003674,GO:0005887,GO:0008150,GO:0070062" molecular_function|integral component of plasma membrane|biological_process|extracellular exosome TSPAN31 714.7541612 659.6224016 769.8859208 1.167161574 0.223004292 0.383873563 1 19.93365529 22.87647489 6302 tetraspanin 31 "GO:0005515,GO:0005887,GO:0008284,GO:0016020" protein binding|integral component of plasma membrane|positive regulation of cell population proliferation|membrane TSPAN33 158.8970892 134.2133909 183.5807876 1.367827654 0.451886463 0.256633773 1 3.433711408 4.618132081 340348 tetraspanin 33 "GO:0005515,GO:0005788,GO:0005886,GO:0005887,GO:0005912,GO:0009986,GO:0019899,GO:0044267,GO:0046930,GO:0046931,GO:0051604,GO:0072659,GO:0097197" protein binding|endoplasmic reticulum lumen|plasma membrane|integral component of plasma membrane|adherens junction|cell surface|enzyme binding|cellular protein metabolic process|pore complex|pore complex assembly|protein maturation|protein localization to plasma membrane|tetraspanin-enriched microdomain TSPAN4 1948.232557 1765.582359 2130.882754 1.206900796 0.271307095 0.251857782 1 36.14341599 42.89157051 7106 tetraspanin 4 "GO:0003823,GO:0005178,GO:0005515,GO:0005886,GO:0005887,GO:0005925,GO:0031982,GO:0065003" antigen binding|integrin binding|protein binding|plasma membrane|integral component of plasma membrane|focal adhesion|vesicle|protein-containing complex assembly TSPAN5 1255.787543 1199.597207 1311.97788 1.093682006 0.129193328 0.593983371 1 19.12766602 20.56952324 10098 tetraspanin 5 "GO:0005515,GO:0005788,GO:0005886,GO:0005887,GO:0019899,GO:0044267,GO:0045747,GO:0051604,GO:0072659" protein binding|endoplasmic reticulum lumen|plasma membrane|integral component of plasma membrane|enzyme binding|cellular protein metabolic process|positive regulation of Notch signaling pathway|protein maturation|protein localization to plasma membrane TSPAN6 681.3363852 703.3197847 659.3529858 0.937486759 -0.09312978 0.721508711 1 9.862029496 9.090810783 7105 tetraspanin 6 "GO:0005515,GO:0005887,GO:0039532,GO:0043123,GO:0070062,GO:1901223" protein binding|integral component of plasma membrane|negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|extracellular exosome|negative regulation of NIK/NF-kappaB signaling TSPAN7 33.62536721 37.45489978 29.79583464 0.795512331 -0.330043801 0.661346911 1 1.147473686 0.897554502 7102 tetraspanin 7 "GO:0005515,GO:0005887,GO:0016032" protein binding|integral component of plasma membrane|viral process hsa05202 Transcriptional misregulation in cancer TSPAN9 594.8826534 578.4701187 611.295188 1.056744624 0.079626773 0.767620145 1 6.755336336 7.019209458 10867 tetraspanin 9 "GO:0003674,GO:0005886,GO:0005887,GO:0005925,GO:0008150,GO:0097197" molecular_function|plasma membrane|integral component of plasma membrane|focal adhesion|biological_process|tetraspanin-enriched microdomain TSPO 1542.429056 1356.699703 1728.158409 1.273795819 0.349134041 0.143022379 1 64.4168769 80.68088675 706 translocator protein "GO:0005497,GO:0005515,GO:0005739,GO:0005741,GO:0005783,GO:0005829,GO:0006626,GO:0006700,GO:0006783,GO:0006820,GO:0006821,GO:0006869,GO:0007568,GO:0008202,GO:0008347,GO:0008503,GO:0010042,GO:0010266,GO:0010940,GO:0014012,GO:0015485,GO:0016021,GO:0030325,GO:0031397,GO:0032374,GO:0032570,GO:0032720,GO:0033574,GO:0042127,GO:0042493,GO:0043065,GO:0043231,GO:0044325,GO:0045019,GO:0048266,GO:0050810,GO:0051901,GO:0051928,GO:0060242,GO:0060252,GO:0060253,GO:0070062,GO:0071222,GO:0071294,GO:0071476,GO:0072656,GO:1903147,GO:1903579,GO:2000379" androgen binding|protein binding|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|cytosol|protein targeting to mitochondrion|C21-steroid hormone biosynthetic process|heme biosynthetic process|anion transport|chloride transport|lipid transport|aging|steroid metabolic process|glial cell migration|benzodiazepine receptor activity|response to manganese ion|response to vitamin B1|positive regulation of necrotic cell death|peripheral nervous system axon regeneration|cholesterol binding|integral component of membrane|adrenal gland development|negative regulation of protein ubiquitination|regulation of cholesterol transport|response to progesterone|negative regulation of tumor necrosis factor production|response to testosterone|regulation of cell population proliferation|response to drug|positive regulation of apoptotic process|intracellular membrane-bounded organelle|ion channel binding|negative regulation of nitric oxide biosynthetic process|behavioral response to pain|regulation of steroid biosynthetic process|positive regulation of mitochondrial depolarization|positive regulation of calcium ion transport|contact inhibition|positive regulation of glial cell proliferation|negative regulation of glial cell proliferation|extracellular exosome|cellular response to lipopolysaccharide|cellular response to zinc ion|cellular hypotonic response|maintenance of protein location in mitochondrion|negative regulation of autophagy of mitochondrion|negative regulation of ATP metabolic process|positive regulation of reactive oxygen species metabolic process "hsa04080,hsa04979,hsa05166" Neuroactive ligand-receptor interaction|Cholesterol metabolism|Human T-cell leukemia virus 1 infection TSPYL1 1558.415848 1536.691305 1580.140392 1.028274441 0.040225363 0.868467238 1 16.16605374 16.34497413 7259 TSPY like 1 "GO:0003682,GO:0005634,GO:0005654,GO:0005730,GO:0006334,GO:0008150,GO:0019899,GO:0042393" chromatin binding|nucleus|nucleoplasm|nucleolus|nucleosome assembly|biological_process|enzyme binding|histone binding TSPYL2 840.3378845 777.1891703 903.4865986 1.162505389 0.217237404 0.386275929 1 9.713620049 11.10317705 64061 TSPY like 2 "GO:0000182,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006334,GO:0007049,GO:0008156,GO:0009966,GO:0030308,GO:0036498,GO:0042393,GO:0045786,GO:0045859" rDNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|nucleosome assembly|cell cycle|negative regulation of DNA replication|regulation of signal transduction|negative regulation of cell growth|IRE1-mediated unfolded protein response|histone binding|negative regulation of cell cycle|regulation of protein kinase activity TSPYL4 804.6121822 684.5923348 924.6320297 1.350631584 0.4336342 0.084650915 1 8.885076527 11.79965346 23270 TSPY like 4 "GO:0003682,GO:0005515,GO:0005634,GO:0006334,GO:0042393" chromatin binding|protein binding|nucleus|nucleosome assembly|histone binding TSR1 1600.497276 1758.299462 1442.69509 0.820505904 -0.285414379 0.230416553 1 22.10534998 17.8340625 55720 TSR1 ribosome maturation factor "GO:0000462,GO:0000479,GO:0003723,GO:0003924,GO:0005515,GO:0005525,GO:0005654,GO:0005730,GO:0005829,GO:0030688,GO:0034511" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|GTPase activity|protein binding|GTP binding|nucleoplasm|nucleolus|cytosol|preribosome, small subunit precursor|U3 snoRNA binding" TSR2 1062.274363 1001.918569 1122.630157 1.120480438 0.164117461 0.503553492 1 13.11838876 14.45293182 90121 TSR2 ribosome maturation factor "GO:0000462,GO:0005515" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|protein binding" TSR3 592.806856 561.8234966 623.7902154 1.110295705 0.150943961 0.570080714 1 24.77974168 27.05245063 115939 TSR3 ribosome maturation factor "GO:0000154,GO:0000455,GO:0005829,GO:0016740,GO:0030490,GO:1904047" rRNA modification|enzyme-directed rRNA pseudouridine synthesis|cytosol|transferase activity|maturation of SSU-rRNA|S-adenosyl-L-methionine binding TSSC4 388.8002179 366.2256867 411.3747492 1.123282075 0.167720258 0.569518309 1 3.787016432 4.182704625 10078 tumor suppressing subtransferable candidate 4 GO:0005515 protein binding TSSK3 8.045908318 9.363724944 6.728091692 0.718527267 -0.476885189 0.786592357 1 0.418179741 0.295445528 81629 testis specific serine kinase 3 "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0007275,GO:0007283,GO:0030154,GO:0035556,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|multicellular organism development|spermatogenesis|cell differentiation|intracellular signal transduction|protein serine kinase activity|protein threonine kinase activity TSSK6 31.18284835 36.41448589 25.95121081 0.712661738 -0.488710625 0.511782134 1 1.461183598 1.023904401 83983 testis specific serine kinase 6 "GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0007275,GO:0018105,GO:0035092,GO:0035556,GO:0044877,GO:0106310,GO:0106311" magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|multicellular organism development|peptidyl-serine phosphorylation|sperm chromatin condensation|intracellular signal transduction|protein-containing complex binding|protein serine kinase activity|protein threonine kinase activity TST 145.1534423 151.9004269 138.4064577 0.911165693 -0.134214667 0.756996014 1 7.030916393 6.299128552 7263 thiosulfate sulfurtransferase "GO:0000098,GO:0004792,GO:0005615,GO:0005739,GO:0005759,GO:0008097,GO:0009440,GO:0019346,GO:0030855,GO:0035928,GO:0051029" sulfur amino acid catabolic process|thiosulfate sulfurtransferase activity|extracellular space|mitochondrion|mitochondrial matrix|5S rRNA binding|cyanate catabolic process|transsulfuration|epithelial cell differentiation|rRNA import into mitochondrion|rRNA transport "hsa00270,hsa00920,hsa04122" Cysteine and methionine metabolism|Sulfur metabolism|Sulfur relay system TSTD1 76.14394221 68.66731625 83.62056817 1.217763745 0.284234267 0.594976151 1 5.612019086 6.719753745 100131187 thiosulfate sulfurtransferase like domain containing 1 "GO:0005737,GO:0005829,GO:0036464,GO:0048471,GO:0050337,GO:0070221" "cytoplasm|cytosol|cytoplasmic ribonucleoprotein granule|perinuclear region of cytoplasm|thiosulfate-thiol sulfurtransferase activity|sulfide oxidation, using sulfide:quinone oxidoreductase" TSTD2 538.8085154 595.1167409 482.5002899 0.810765782 -0.302642893 0.260567872 1 7.716299 6.151423646 158427 thiosulfate sulfurtransferase like domain containing 2 "GO:0003674,GO:0005515,GO:0005575,GO:0008150" molecular_function|protein binding|cellular_component|biological_process TSTD3 70.46129482 58.26317743 82.65941222 1.418724757 0.504594723 0.346051809 1 3.679761771 5.133209968 100130890 thiosulfate sulfurtransferase like domain containing 3 TTBK2 1435.001657 1501.317233 1368.686081 0.911656811 -0.133437263 0.578228427 1 6.421619091 5.756348789 146057 tau tubulin kinase 2 "GO:0000226,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005737,GO:0005814,GO:0005829,GO:0007026,GO:0007224,GO:0018105,GO:0019894,GO:0021549,GO:0021681,GO:0021935,GO:0030334,GO:0035869,GO:0036064,GO:0048156,GO:0050321,GO:0051010,GO:0060271,GO:0097711,GO:0106310,GO:0106311,GO:1902817,GO:1904527" microtubule cytoskeleton organization|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|extracellular space|nucleus|cytoplasm|centriole|cytosol|negative regulation of microtubule depolymerization|smoothened signaling pathway|peptidyl-serine phosphorylation|kinesin binding|cerebellum development|cerebellar granular layer development|cerebellar granule cell precursor tangential migration|regulation of cell migration|ciliary transition zone|ciliary basal body|tau protein binding|tau-protein kinase activity|microtubule plus-end binding|cilium assembly|ciliary basal body-plasma membrane docking|protein serine kinase activity|protein threonine kinase activity|negative regulation of protein localization to microtubule|negative regulation of microtubule binding TTC1 1009.401339 925.9683556 1092.834322 1.180206986 0.239039903 0.33104099 1 34.36524985 39.87942293 7265 tetratricopeptide repeat domain 1 "GO:0005515,GO:0005778,GO:0005829,GO:0006457,GO:0051082" protein binding|peroxisomal membrane|cytosol|protein folding|unfolded protein binding TTC12 126.7430241 122.7688382 130.71721 1.064742584 0.090504682 0.850912314 1 1.726013502 1.80700765 54970 tetratricopeptide repeat domain 12 "GO:0005737,GO:0005813,GO:0007288,GO:0070286" cytoplasm|centrosome|sperm axoneme assembly|axonemal dynein complex assembly TTC13 399.1892655 424.4888641 373.8896669 0.880799706 -0.183114107 0.530573386 1 5.522718308 4.783009373 79573 tetratricopeptide repeat domain 13 TTC14 836.3743738 774.0679287 898.6808189 1.160984438 0.215348634 0.390709125 1 8.945557098 10.21186275 151613 tetratricopeptide repeat domain 14 GO:0003676 nucleic acid binding TTC17 1843.399933 2129.727218 1557.072649 0.731113654 -0.451832399 0.056638176 1 20.00697542 14.38260363 55761 tetratricopeptide repeat domain 17 "GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0015629,GO:0030041,GO:0044782" protein binding|cytoplasm|cytosol|plasma membrane|actin cytoskeleton|actin filament polymerization|cilium organization TTC19 1151.463108 1097.636646 1205.289569 1.098077012 0.134979239 0.580173628 1 13.59138061 14.67464328 54902 tetratricopeptide repeat domain 19 "GO:0000281,GO:0005515,GO:0005739,GO:0005743,GO:0005813,GO:0030496,GO:0034551,GO:0055114,GO:0070469" mitotic cytokinesis|protein binding|mitochondrion|mitochondrial inner membrane|centrosome|midbody|mitochondrial respiratory chain complex III assembly|oxidation-reduction process|respirasome TTC21A 131.0235665 134.2133909 127.8337421 0.952466377 -0.07025993 0.886694666 1 1.607433123 1.505406356 199223 tetratricopeptide repeat domain 21A "GO:0005929,GO:0007286,GO:0030317,GO:0030991,GO:0035721,GO:0061512" cilium|spermatid development|flagellated sperm motility|intraciliary transport particle A|intraciliary retrograde transport|protein localization to cilium TTC21B 1015.831906 968.6253247 1063.038487 1.097471293 0.134183203 0.586662923 1 2.800766827 3.022325959 79809 tetratricopeptide repeat domain 21B "GO:0005737,GO:0005856,GO:0005929,GO:0006357,GO:0030991,GO:0035721,GO:0035735,GO:0061512,GO:0097542,GO:1905799" cytoplasm|cytoskeleton|cilium|regulation of transcription by RNA polymerase II|intraciliary transport particle A|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|protein localization to cilium|ciliary tip|regulation of intraciliary retrograde transport TTC23 539.7205959 518.1261136 561.3150783 1.083356086 0.115507517 0.671851491 1 5.814011439 6.193245387 64927 tetratricopeptide repeat domain 23 "GO:0005515,GO:0005929,GO:0045880" protein binding|cilium|positive regulation of smoothened signaling pathway TTC23L 6.004709516 6.242483296 5.766935736 0.923820772 -0.11431511 1 1 0.050067607 0.045479506 153657 tetratricopeptide repeat domain 23 like "GO:0005515,GO:0005737,GO:0005815,GO:0005819,GO:0030496,GO:0034976" protein binding|cytoplasm|microtubule organizing center|spindle|midbody|response to endoplasmic reticulum stress TTC26 409.0832582 419.2867947 398.8797217 0.951329083 -0.071983612 0.809709548 1 4.621347711 4.322854302 79989 tetratricopeptide repeat domain 26 "GO:0005813,GO:0005929,GO:0007224,GO:0030992,GO:0035082,GO:0035720,GO:0035735,GO:0036064,GO:0042073,GO:0060271,GO:0061512,GO:0097542,GO:0097546,GO:0120170,GO:1905198" centrosome|cilium|smoothened signaling pathway|intraciliary transport particle B|axoneme assembly|intraciliary anterograde transport|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|cilium assembly|protein localization to cilium|ciliary tip|ciliary base|intraciliary transport particle B binding|manchette assembly TTC27 409.5537754 444.2567279 374.8508228 0.843770728 -0.245077056 0.39567585 1 8.167125408 6.775866766 55622 tetratricopeptide repeat domain 27 "GO:0003674,GO:0005515,GO:0005575,GO:0008150" molecular_function|protein binding|cellular_component|biological_process TTC28 888.4196056 916.6046306 860.2345806 0.938501238 -0.091569447 0.715898479 1 3.023518418 2.790092791 23331 tetratricopeptide repeat domain 28 "GO:0000922,GO:0005737,GO:0005815,GO:0007049,GO:0007346,GO:0019900,GO:0030496,GO:0051301" spindle pole|cytoplasm|microtubule organizing center|cell cycle|regulation of mitotic cell cycle|kinase binding|midbody|cell division TTC3 4157.232215 4094.028628 4220.435803 1.030875987 0.043870789 0.854887053 1 16.95698746 17.18803783 7267 tetratricopeptide repeat domain 3 "GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005794,GO:0005829,GO:0006511,GO:0046872,GO:0070936" ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|nucleolus|Golgi apparatus|cytosol|ubiquitin-dependent protein catabolic process|metal ion binding|protein K48-linked ubiquitination TTC30A 134.0655502 138.3750464 129.7560541 0.937712813 -0.092781948 0.842462607 1 1.285658409 1.185404643 92104 tetratricopeptide repeat domain 30A "GO:0005879,GO:0030992,GO:0036064,GO:0042073,GO:0120170" axonemal microtubule|intraciliary transport particle B|ciliary basal body|intraciliary transport|intraciliary transport particle B binding TTC30B 114.8870905 126.9304937 102.8436873 0.810236251 -0.303585461 0.503342769 1 1.78311323 1.42056716 150737 tetratricopeptide repeat domain 30B "GO:0005515,GO:0005879,GO:0005929,GO:0030992,GO:0035735,GO:0036064,GO:0042073,GO:0097542,GO:0120170" protein binding|axonemal microtubule|cilium|intraciliary transport particle B|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|ciliary tip|intraciliary transport particle B binding TTC31 609.9189649 632.5716406 587.2662891 0.928379098 -0.107214054 0.68677736 1 10.4002421 9.493797878 64427 tetratricopeptide repeat domain 31 TTC32 92.11687196 84.27352449 99.96021942 1.18614025 0.246274605 0.622335711 1 4.779514468 5.574308529 130502 tetratricopeptide repeat domain 32 GO:0005515 protein binding TTC33 640.7457669 558.702255 722.7892789 1.293693148 0.371495464 0.152943713 1 5.29890039 6.740439455 23548 tetratricopeptide repeat domain 33 GO:0005515 protein binding TTC34 3.443303773 2.080827765 4.80577978 2.309551929 1.207612985 0.648665767 1 0.015685022 0.03561919 100287898 tetratricopeptide repeat domain 34 TTC37 2958.038403 2979.74536 2936.331446 0.985430327 -0.021174222 0.9301801 1 28.01189595 27.14186006 9652 tetratricopeptide repeat domain 37 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0034427,GO:0035327,GO:0043928,GO:0055087" "protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|transcriptionally active chromatin|exonucleolytic catabolism of deadenylated mRNA|Ski complex" hsa03018 RNA degradation TTC38 326.8157196 341.2557535 312.3756857 0.915371192 -0.127571207 0.684019767 1 4.27315635 3.846070159 55020 tetratricopeptide repeat domain 38 GO:0070062 extracellular exosome TTC39A 23.30048631 18.72744989 27.87352272 1.48837791 0.573740884 0.49496389 1 0.223891035 0.327658243 22996 tetratricopeptide repeat domain 39A "GO:0003674,GO:0005575,GO:0005813,GO:0008150" molecular_function|cellular_component|centrosome|biological_process TTC39B 317.4274569 284.03299 350.8219239 1.235144988 0.304680403 0.326245042 1 1.250892775 1.51917989 158219 tetratricopeptide repeat domain 39B "GO:0005515,GO:0006629,GO:0010874,GO:0010887,GO:0042632,GO:0090181" protein binding|lipid metabolic process|regulation of cholesterol efflux|negative regulation of cholesterol storage|cholesterol homeostasis|regulation of cholesterol metabolic process TTC39C 378.3262676 419.2867947 337.3657406 0.804618092 -0.313623918 0.286432065 1 2.380992298 1.883731336 125488 tetratricopeptide repeat domain 39C "GO:0032474,GO:0060271" otolith morphogenesis|cilium assembly TTC4 724.4097657 749.0979955 699.721536 0.934085447 -0.098373566 0.703356261 1 16.96858372 15.58487703 7268 tetratricopeptide repeat domain 4 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0045087,GO:0051607,GO:0051879" protein binding|nucleus|nucleoplasm|cytoplasm|innate immune response|defense response to virus|Hsp90 protein binding TTC5 387.987517 395.3572754 380.6177586 0.962718488 -0.054814098 0.859330827 1 4.454188548 4.216373624 91875 tetratricopeptide repeat domain 5 "GO:0003677,GO:0003682,GO:0005515,GO:0005654,GO:0005737,GO:0006281,GO:0045944,GO:1901796" DNA binding|chromatin binding|protein binding|nucleoplasm|cytoplasm|DNA repair|positive regulation of transcription by RNA polymerase II|regulation of signal transduction by p53 class mediator TTC6 18.45507756 17.687036 19.22311912 1.086847967 0.120150144 0.958973096 1 0.095220882 0.101758847 319089 tetratricopeptide repeat domain 6 TTC7A 721.1444851 802.1591035 640.1298667 0.798008604 -0.325523793 0.201960804 1 5.570560449 4.370968171 57217 tetratricopeptide repeat domain 7A "GO:0005737,GO:0005886,GO:0006879,GO:0030097,GO:0046854,GO:0072659" cytoplasm|plasma membrane|cellular iron ion homeostasis|hemopoiesis|phosphatidylinositol phosphorylation|protein localization to plasma membrane TTC7B 1147.123429 1034.171399 1260.075458 1.21843967 0.285034819 0.240992426 1 2.835002407 3.396476709 145567 tetratricopeptide repeat domain 7B "GO:0005515,GO:0005829,GO:0005886,GO:0046854,GO:0072659" protein binding|cytosol|plasma membrane|phosphatidylinositol phosphorylation|protein localization to plasma membrane TTC8 570.0561448 570.1468077 569.9654819 0.999681967 -0.000458898 1 1 8.899586792 8.747881255 123016 tetratricopeptide repeat domain 8 "GO:0001103,GO:0005515,GO:0005813,GO:0005829,GO:0005929,GO:0015031,GO:0034464,GO:0036064,GO:0048560,GO:0050893,GO:0060170,GO:0060271,GO:0097730,GO:1905515" RNA polymerase II repressing transcription factor binding|protein binding|centrosome|cytosol|cilium|protein transport|BBSome|ciliary basal body|establishment of anatomical structure orientation|sensory processing|ciliary membrane|cilium assembly|non-motile cilium|non-motile cilium assembly TTC9 32.03014784 20.80827765 43.25201802 2.078596736 1.055609892 0.138939387 1 0.218001479 0.445554526 23508 tetratricopeptide repeat domain 9 TTC9C 715.0711929 667.9457127 762.1966731 1.14110572 0.190432459 0.457709876 1 34.84558656 39.09712657 283237 tetratricopeptide repeat domain 9C GO:0005515 protein binding TTF1 505.084383 504.6007331 505.5680329 1.001916961 0.002762942 1 1 8.381454624 8.257000393 7270 transcription termination factor 1 "GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0006353,GO:0006363,GO:0008156,GO:0044267" "DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|plasma membrane|DNA-templated transcription, termination|termination of RNA polymerase I transcription|negative regulation of DNA replication|cellular protein metabolic process" hsa04918 Thyroid hormone synthesis TTF2 1495.01857 1638.651865 1351.385274 0.824693337 -0.278070344 0.244063978 1 9.809516358 7.954470212 8458 transcription termination factor 2 "GO:0003677,GO:0004386,GO:0005515,GO:0005524,GO:0005681,GO:0005829,GO:0006353,GO:0006369,GO:0006397,GO:0008023,GO:0008094,GO:0008270,GO:0008380" "DNA binding|helicase activity|protein binding|ATP binding|spliceosomal complex|cytosol|DNA-templated transcription, termination|termination of RNA polymerase II transcription|mRNA processing|transcription elongation factor complex|DNA-dependent ATPase activity|zinc ion binding|RNA splicing" hsa04918 Thyroid hormone synthesis other TTI1 1363.301189 1536.691305 1189.911074 0.774333186 -0.368973621 0.123995053 1 19.55888161 14.89165852 9675 TELO2 interacting protein 1 "GO:0005515,GO:0005737,GO:0031931,GO:0031932,GO:0032006,GO:0070209" protein binding|cytoplasm|TORC1 complex|TORC2 complex|regulation of TOR signaling|ASTRA complex hsa04150 mTOR signaling pathway TTI2 234.3522478 222.6485709 246.0559247 1.10513139 0.144217904 0.682465594 1 4.752938007 5.16472549 80185 TELO2 interacting protein 2 "GO:0005654,GO:0005813,GO:0005829,GO:0070209" nucleoplasm|centrosome|cytosol|ASTRA complex TTK 1648.089587 1720.844562 1575.334612 0.915442712 -0.12745849 0.593006288 1 25.86266164 23.2796029 7272 TTK protein kinase "GO:0000776,GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005819,GO:0007051,GO:0007052,GO:0007059,GO:0007094,GO:0008284,GO:0010862,GO:0016020,GO:0016321,GO:0018105,GO:0018107,GO:0018108,GO:0033316,GO:0034501,GO:0043515,GO:0046777,GO:0051304,GO:1903096" kinetochore|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|spindle|spindle organization|mitotic spindle organization|chromosome segregation|mitotic spindle assembly checkpoint|positive regulation of cell population proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|membrane|female meiosis chromosome segregation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|meiotic spindle assembly checkpoint|protein localization to kinetochore|kinetochore binding|protein autophosphorylation|chromosome separation|protein localization to meiotic spindle midzone hsa04110 Cell cycle TTL 2329.387572 2221.283639 2437.491504 1.09733465 0.134003566 0.571503784 1 8.223212076 8.872617557 150465 tubulin tyrosine ligase "GO:0000226,GO:0004835,GO:0005524,GO:0005876,GO:0018166,GO:0018215,GO:0030516,GO:0045931,GO:0090235" microtubule cytoskeleton organization|tubulin-tyrosine ligase activity|ATP binding|spindle microtubule|C-terminal protein-tyrosinylation|protein phosphopantetheinylation|regulation of axon extension|positive regulation of mitotic cell cycle|regulation of metaphase plate congression TTLL1 41.15106858 45.77821084 36.52392633 0.797845212 -0.325819215 0.634831261 1 1.214867715 0.953056862 25809 tubulin tyrosine ligase like 1 "GO:0000226,GO:0002395,GO:0005524,GO:0005576,GO:0005737,GO:0005874,GO:0005929,GO:0007288,GO:0015631,GO:0018095,GO:0018215,GO:0021702,GO:0036064,GO:0070740,GO:0120197,GO:0120222" microtubule cytoskeleton organization|immune response in nasopharyngeal-associated lymphoid tissue|ATP binding|extracellular region|cytoplasm|microtubule|cilium|sperm axoneme assembly|tubulin binding|protein polyglutamylation|protein phosphopantetheinylation|cerebellar Purkinje cell differentiation|ciliary basal body|tubulin-glutamic acid ligase activity|mucociliary clearance|regulation of blastocyst development TTLL11 138.6039881 106.122216 171.0857602 1.612157817 0.688992979 0.099278688 1 0.405669195 0.643058913 158135 tubulin tyrosine ligase like 11 "GO:0000226,GO:0005524,GO:0005829,GO:0005874,GO:0005929,GO:0015631,GO:0018095,GO:0018215,GO:0036064,GO:0051013,GO:0070740" microtubule cytoskeleton organization|ATP binding|cytosol|microtubule|cilium|tubulin binding|protein polyglutamylation|protein phosphopantetheinylation|ciliary basal body|microtubule severing|tubulin-glutamic acid ligase activity TTLL12 1531.136146 1653.21766 1409.054631 0.852310416 -0.230549131 0.333806141 1 26.05705493 21.83706683 23170 tubulin tyrosine ligase like 12 "GO:0004835,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005815,GO:0005819,GO:0007346,GO:0015631,GO:0018024,GO:0018215,GO:0030496,GO:0034968,GO:0045087,GO:0060339,GO:0070510,GO:1990889" tubulin-tyrosine ligase activity|protein binding|ATP binding|nucleus|cytoplasm|microtubule organizing center|spindle|regulation of mitotic cell cycle|tubulin binding|histone-lysine N-methyltransferase activity|protein phosphopantetheinylation|midbody|histone lysine methylation|innate immune response|negative regulation of type I interferon-mediated signaling pathway|regulation of histone H4-K20 methylation|H4K20me3 modified histone binding TTLL3 60.36915728 58.26317743 62.47513714 1.072291967 0.100697781 0.886674989 1 0.70459975 0.742893769 26140 tubulin tyrosine ligase like 3 "GO:0005524,GO:0005829,GO:0005874,GO:0005929,GO:0005930,GO:0015630,GO:0018094,GO:0018215,GO:0035082,GO:0060271,GO:0070735,GO:0070736" "ATP binding|cytosol|microtubule|cilium|axoneme|microtubule cytoskeleton|protein polyglycylation|protein phosphopantetheinylation|axoneme assembly|cilium assembly|protein-glycine ligase activity|protein-glycine ligase activity, initiating" TTLL4 900.6762449 1011.282294 790.0701958 0.781255838 -0.35613303 0.151414899 1 6.71105165 5.155312967 9654 tubulin tyrosine ligase like 4 "GO:0000226,GO:0005524,GO:0005829,GO:0005874,GO:0005929,GO:0015631,GO:0018095,GO:0018200,GO:0018215,GO:0036064,GO:0070739,GO:0070740,GO:0097731,GO:0120222" microtubule cytoskeleton organization|ATP binding|cytosol|microtubule|cilium|tubulin binding|protein polyglutamylation|peptidyl-glutamic acid modification|protein phosphopantetheinylation|ciliary basal body|protein-glutamic acid ligase activity|tubulin-glutamic acid ligase activity|9+0 non-motile cilium|regulation of blastocyst development TTLL5 1284.944284 1195.435551 1374.453017 1.14975083 0.201321239 0.403960369 1 13.52803186 15.29359298 23093 tubulin tyrosine ligase like 5 "GO:0000226,GO:0005524,GO:0005634,GO:0005813,GO:0005829,GO:0005874,GO:0005886,GO:0005929,GO:0015631,GO:0018095,GO:0018215,GO:0060041,GO:0070740" microtubule cytoskeleton organization|ATP binding|nucleus|centrosome|cytosol|microtubule|plasma membrane|cilium|tubulin binding|protein polyglutamylation|protein phosphopantetheinylation|retina development in camera-type eye|tubulin-glutamic acid ligase activity TTLL6 22.78027936 17.687036 27.87352272 1.575929552 0.656203044 0.433950845 1 0.227506533 0.352534683 284076 tubulin tyrosine ligase like 6 "GO:0000226,GO:0001578,GO:0003353,GO:0005515,GO:0005524,GO:0005829,GO:0005874,GO:0005929,GO:0015631,GO:0018095,GO:0018215,GO:0036064,GO:0051013,GO:0070739,GO:0070740,GO:0097731" microtubule cytoskeleton organization|microtubule bundle formation|positive regulation of cilium movement|protein binding|ATP binding|cytosol|microtubule|cilium|tubulin binding|protein polyglutamylation|protein phosphopantetheinylation|ciliary basal body|microtubule severing|protein-glutamic acid ligase activity|tubulin-glutamic acid ligase activity|9+0 non-motile cilium TTLL7 685.1269032 638.8141239 731.4396825 1.144996103 0.195342688 0.449093642 1 4.271152055 4.80861736 79739 tubulin tyrosine ligase like 7 "GO:0000226,GO:0005524,GO:0005829,GO:0005874,GO:0005929,GO:0007399,GO:0015631,GO:0018095,GO:0018215,GO:0030154,GO:0030425,GO:0043014,GO:0043204,GO:0048487,GO:0070740" microtubule cytoskeleton organization|ATP binding|cytosol|microtubule|cilium|nervous system development|tubulin binding|protein polyglutamylation|protein phosphopantetheinylation|cell differentiation|dendrite|alpha-tubulin binding|perikaryon|beta-tubulin binding|tubulin-glutamic acid ligase activity TTN 2.923096831 1.040413883 4.80577978 4.619103859 2.207612985 0.416510993 1 0.000474901 0.002156911 7273 titin "GO:0000794,GO:0002020,GO:0002576,GO:0003300,GO:0004674,GO:0004713,GO:0005509,GO:0005515,GO:0005516,GO:0005524,GO:0005576,GO:0005829,GO:0006936,GO:0006941,GO:0007076,GO:0008307,GO:0010628,GO:0010737,GO:0018108,GO:0019899,GO:0019901,GO:0030018,GO:0030049,GO:0030240,GO:0030241,GO:0031433,GO:0031674,GO:0035995,GO:0042802,GO:0042805,GO:0043621,GO:0045214,GO:0045859,GO:0048739,GO:0048769,GO:0050714,GO:0050790,GO:0051015,GO:0051371,GO:0051592,GO:0055003,GO:0055008,GO:0060048,GO:0070062,GO:0097493,GO:0106310,GO:0106311" condensed nuclear chromosome|protease binding|platelet degranulation|cardiac muscle hypertrophy|protein serine/threonine kinase activity|protein tyrosine kinase activity|calcium ion binding|protein binding|calmodulin binding|ATP binding|extracellular region|cytosol|muscle contraction|striated muscle contraction|mitotic chromosome condensation|structural constituent of muscle|positive regulation of gene expression|protein kinase A signaling|peptidyl-tyrosine phosphorylation|enzyme binding|protein kinase binding|Z disc|muscle filament sliding|skeletal muscle thin filament assembly|skeletal muscle myosin thick filament assembly|telethonin binding|I band|detection of muscle stretch|identical protein binding|actinin binding|protein self-association|sarcomere organization|regulation of protein kinase activity|cardiac muscle fiber development|sarcomerogenesis|positive regulation of protein secretion|regulation of catalytic activity|actin filament binding|muscle alpha-actinin binding|response to calcium ion|cardiac myofibril assembly|cardiac muscle tissue morphogenesis|cardiac muscle contraction|extracellular exosome|structural molecule activity conferring elasticity|protein serine kinase activity|protein threonine kinase activity "hsa05410,hsa05414" Hypertrophic cardiomyopathy|Dilated cardiomyopathy TTPA 61.6127464 53.06110801 70.16438479 1.322331693 0.403084107 0.479078841 1 0.91259227 1.186556359 7274 alpha tocopherol transfer protein "GO:0005515,GO:0005546,GO:0005770,GO:0005829,GO:0006629,GO:0007584,GO:0008431,GO:0009268,GO:0032502,GO:0042360,GO:0043325,GO:0051180,GO:0051452,GO:0060548,GO:0120009,GO:0120013,GO:1902936" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|late endosome|cytosol|lipid metabolic process|response to nutrient|vitamin E binding|response to pH|developmental process|vitamin E metabolic process|phosphatidylinositol-3,4-bisphosphate binding|vitamin transport|intracellular pH reduction|negative regulation of cell death|intermembrane lipid transfer|lipid transfer activity|phosphatidylinositol bisphosphate binding" TTPAL 1161.113682 1199.597207 1122.630157 0.935839255 -0.095667349 0.695854682 1 8.734010662 8.036855405 79183 alpha tocopherol transfer protein like "GO:0016020,GO:1902936" membrane|phosphatidylinositol bisphosphate binding TTYH2 17.05297259 18.72744989 15.3784953 0.821174019 -0.284240111 0.809190529 1 0.240194564 0.193940966 94015 tweety family member 2 "GO:0005229,GO:0005515,GO:0005886,GO:0034707,GO:0072320,GO:1902476" intracellular calcium activated chloride channel activity|protein binding|plasma membrane|chloride channel complex|volume-sensitive chloride channel activity|chloride transmembrane transport TTYH3 1063.026084 1223.526726 902.5254427 0.737642606 -0.439006107 0.07253487 1 34.95576693 25.35338825 80727 tweety family member 3 "GO:0005229,GO:0005254,GO:0005886,GO:0006821,GO:0034220,GO:0034707,GO:0070062,GO:0072320,GO:1902476" intracellular calcium activated chloride channel activity|chloride channel activity|plasma membrane|chloride transport|ion transmembrane transport|chloride channel complex|extracellular exosome|volume-sensitive chloride channel activity|chloride transmembrane transport TUBA1A 4624.772265 3751.732461 5497.812068 1.465406216 0.55130064 0.021492757 0.822216713 89.70567475 129.2555277 7846 tubulin alpha 1a "GO:0000086,GO:0000226,GO:0000278,GO:0003924,GO:0005198,GO:0005200,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005829,GO:0005874,GO:0005881,GO:0007017,GO:0010389,GO:0015630,GO:0019904,GO:0030705,GO:0031594,GO:0036464,GO:0042802,GO:0043209,GO:0045121,GO:0050807,GO:0051301,GO:0055037,GO:0070062,GO:0097711" G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|mitotic cell cycle|GTPase activity|structural molecule activity|structural constituent of cytoskeleton|protein binding|GTP binding|nucleus|cytoplasm|cytosol|microtubule|cytoplasmic microtubule|microtubule-based process|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|protein domain specific binding|cytoskeleton-dependent intracellular transport|neuromuscular junction|cytoplasmic ribonucleoprotein granule|identical protein binding|myelin sheath|membrane raft|regulation of synapse organization|cell division|recycling endosome|extracellular exosome|ciliary basal body-plasma membrane docking "hsa04145,hsa04210,hsa04530,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Apoptosis|Tight junction|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBA1B 42396.76971 38713.80057 46079.73884 1.190266472 0.251284595 0.42436 1 1269.873622 1486.195292 10376 tubulin alpha 1b "GO:0000226,GO:0000278,GO:0003725,GO:0003924,GO:0005198,GO:0005200,GO:0005515,GO:0005525,GO:0005737,GO:0005874,GO:0005881,GO:0007017,GO:0015630,GO:0030705,GO:0031625,GO:0045121,GO:0051301,GO:0071353" microtubule cytoskeleton organization|mitotic cell cycle|double-stranded RNA binding|GTPase activity|structural molecule activity|structural constituent of cytoskeleton|protein binding|GTP binding|cytoplasm|microtubule|cytoplasmic microtubule|microtubule-based process|microtubule cytoskeleton|cytoskeleton-dependent intracellular transport|ubiquitin protein ligase binding|membrane raft|cell division|cellular response to interleukin-4 "hsa04145,hsa04210,hsa04530,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Apoptosis|Tight junction|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBA1C 15862.69188 15967.23186 15758.1519 0.986905685 -0.019015876 0.942900069 1 258.4597567 250.8070618 84790 tubulin alpha 1c "GO:0000226,GO:0000278,GO:0003924,GO:0005198,GO:0005200,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005874,GO:0007017,GO:0015630,GO:0030705,GO:0031982,GO:0051301" microtubule cytoskeleton organization|mitotic cell cycle|GTPase activity|structural molecule activity|structural constituent of cytoskeleton|protein binding|GTP binding|nucleus|cytoplasm|microtubule|microtubule-based process|microtubule cytoskeleton|cytoskeleton-dependent intracellular transport|vesicle|cell division "hsa04145,hsa04210,hsa04530,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Apoptosis|Tight junction|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBA4A 1892.979952 1929.967752 1855.992151 0.961670032 -0.056386132 0.813680065 1 38.24687405 36.16539452 7277 tubulin alpha 4a "GO:0000086,GO:0000226,GO:0000278,GO:0002576,GO:0003924,GO:0005200,GO:0005515,GO:0005525,GO:0005576,GO:0005737,GO:0005829,GO:0005856,GO:0005874,GO:0010389,GO:0015630,GO:0019901,GO:0070062,GO:0097711" G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|mitotic cell cycle|platelet degranulation|GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|extracellular region|cytoplasm|cytosol|cytoskeleton|microtubule|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|protein kinase binding|extracellular exosome|ciliary basal body-plasma membrane docking "hsa04145,hsa04210,hsa04530,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Apoptosis|Tight junction|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBA8 10.12673608 13.52538047 6.728091692 0.497441954 -1.007399906 0.399736103 1 0.365666007 0.178853803 51807 tubulin alpha 8 "GO:0000226,GO:0000278,GO:0003924,GO:0005200,GO:0005515,GO:0005525,GO:0005737,GO:0005874,GO:0015630" microtubule cytoskeleton organization|mitotic cell cycle|GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|cytoplasm|microtubule|microtubule cytoskeleton "hsa04145,hsa04210,hsa04530,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Apoptosis|Tight junction|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBAL3 12.76739975 19.76786377 5.766935736 0.291732875 -1.777280123 0.091403032 1 0.588385141 0.168778937 79861 tubulin alpha like 3 "GO:0000226,GO:0000278,GO:0003924,GO:0005200,GO:0005525,GO:0005737,GO:0005874" microtubule cytoskeleton organization|mitotic cell cycle|GTPase activity|structural constituent of cytoskeleton|GTP binding|cytoplasm|microtubule "hsa04145,hsa04210,hsa04530,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Apoptosis|Tight junction|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBB 40381.19341 37501.7184 43260.66842 1.153564964 0.206099252 0.507931252 1 754.6748815 855.9987508 203068 tubulin beta class I "GO:0000086,GO:0000226,GO:0000278,GO:0003924,GO:0005198,GO:0005200,GO:0005515,GO:0005525,GO:0005576,GO:0005634,GO:0005641,GO:0005737,GO:0005856,GO:0005874,GO:0007017,GO:0009987,GO:0010389,GO:0019904,GO:0030705,GO:0031625,GO:0032794,GO:0032991,GO:0035578,GO:0036464,GO:0042267,GO:0042288,GO:0043312,GO:0044297,GO:0044877,GO:0045121,GO:0050807,GO:0051225,GO:0051301,GO:0070062,GO:0097711" G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|mitotic cell cycle|GTPase activity|structural molecule activity|structural constituent of cytoskeleton|protein binding|GTP binding|extracellular region|nucleus|nuclear envelope lumen|cytoplasm|cytoskeleton|microtubule|microtubule-based process|cellular process|regulation of G2/M transition of mitotic cell cycle|protein domain specific binding|cytoskeleton-dependent intracellular transport|ubiquitin protein ligase binding|GTPase activating protein binding|protein-containing complex|azurophil granule lumen|cytoplasmic ribonucleoprotein granule|natural killer cell mediated cytotoxicity|MHC class I protein binding|neutrophil degranulation|cell body|protein-containing complex binding|membrane raft|regulation of synapse organization|spindle assembly|cell division|extracellular exosome|ciliary basal body-plasma membrane docking "hsa04145,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBB2A 647.6713891 664.824471 630.5183071 0.948398163 -0.076435226 0.773082486 1 20.29774607 18.92821663 7280 tubulin beta 2A class IIa "GO:0000226,GO:0000278,GO:0001764,GO:0003924,GO:0005200,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005874,GO:0070062,GO:1903561" microtubule cytoskeleton organization|mitotic cell cycle|neuron migration|GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|nucleus|cytoplasm|microtubule|extracellular exosome|extracellular vesicle "hsa04145,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBB2B 62.93056303 62.42483296 63.4362931 1.016202849 0.023188414 0.999791484 1 1.73334995 1.731959925 347733 tubulin beta 2B class IIb "GO:0000226,GO:0000278,GO:0001764,GO:0003924,GO:0005200,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005874,GO:0007017,GO:0015630,GO:0046982,GO:0050804,GO:0098685,GO:1902669,GO:1990403" microtubule cytoskeleton organization|mitotic cell cycle|neuron migration|GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|nucleus|cytoplasm|microtubule|microtubule-based process|microtubule cytoskeleton|protein heterodimerization activity|modulation of chemical synaptic transmission|Schaffer collateral - CA1 synapse|positive regulation of axon guidance|embryonic brain development "hsa04145,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBB3 1841.734173 1492.993922 2190.474424 1.467169017 0.553035078 0.019785498 0.808379488 39.30850596 56.70715551 10381 tubulin beta 3 class III "GO:0000226,GO:0000278,GO:0003924,GO:0005200,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005874,GO:0007411,GO:0030027,GO:0030175,GO:0030424,GO:0030425,GO:0030426,GO:0038007,GO:0070062,GO:1990791,GO:1990890" microtubule cytoskeleton organization|mitotic cell cycle|GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|nucleus|cytoplasm|microtubule|axon guidance|lamellipodium|filopodium|axon|dendrite|growth cone|netrin-activated signaling pathway|extracellular exosome|dorsal root ganglion development|netrin receptor binding "hsa04145,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBB4A 29.30519582 24.96993318 33.64045846 1.347238625 0.430005406 0.581325278 1 0.544584978 0.721408677 10382 tubulin beta 4A class IVa "GO:0000086,GO:0000226,GO:0000278,GO:0003924,GO:0005200,GO:0005509,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005829,GO:0005874,GO:0005930,GO:0010389,GO:0031115,GO:0033269,GO:0043025,GO:0043209,GO:0070062,GO:0097711" G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|mitotic cell cycle|GTPase activity|structural constituent of cytoskeleton|calcium ion binding|protein binding|GTP binding|nucleus|cytoplasm|cytosol|microtubule|axoneme|regulation of G2/M transition of mitotic cell cycle|negative regulation of microtubule polymerization|internode region of axon|neuronal cell body|myelin sheath|extracellular exosome|ciliary basal body-plasma membrane docking "hsa04145,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBB4B 15028.14412 14635.50209 15420.78616 1.053656107 0.075404076 0.774146968 1 499.7247905 517.7271758 10383 tubulin beta 4B class IVb "GO:0000086,GO:0000226,GO:0000278,GO:0003725,GO:0003924,GO:0005200,GO:0005515,GO:0005525,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005874,GO:0010389,GO:0035578,GO:0042267,GO:0042288,GO:0043312,GO:0051082,GO:0070062,GO:0097711,GO:1903561" G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|mitotic cell cycle|double-stranded RNA binding|GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|extracellular region|nucleus|cytoplasm|cytosol|cytoskeleton|microtubule|regulation of G2/M transition of mitotic cell cycle|azurophil granule lumen|natural killer cell mediated cytotoxicity|MHC class I protein binding|neutrophil degranulation|unfolded protein binding|extracellular exosome|ciliary basal body-plasma membrane docking|extracellular vesicle "hsa04145,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBB6 12014.8881 10142.99494 13886.78125 1.369100678 0.45322854 0.076964742 1 173.0540275 232.9637107 84617 tubulin beta 6 class V "GO:0000226,GO:0000278,GO:0003674,GO:0003924,GO:0005200,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005874,GO:0070062" microtubule cytoskeleton organization|mitotic cell cycle|molecular_function|GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|nucleus|cytoplasm|microtubule|extracellular exosome "hsa04145,hsa04540,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05130,hsa05132" Phagosome|Gap junction|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Pathogenic Escherichia coli infection|Salmonella infection TUBD1 150.5140275 166.4662212 134.5618338 0.808343175 -0.306960188 0.453754566 1 3.396023041 2.699215646 51174 tubulin delta 1 "GO:0000226,GO:0000278,GO:0003924,GO:0005200,GO:0005525,GO:0005654,GO:0005737,GO:0005814,GO:0005829,GO:0005874,GO:0005929,GO:0007275,GO:0030030,GO:0045880" microtubule cytoskeleton organization|mitotic cell cycle|GTPase activity|structural constituent of cytoskeleton|GTP binding|nucleoplasm|cytoplasm|centriole|cytosol|microtubule|cilium|multicellular organism development|cell projection organization|positive regulation of smoothened signaling pathway TUBE1 321.8860225 350.6194785 293.1525666 0.836098918 -0.258254459 0.404081479 1 8.117968396 6.673846234 51175 tubulin epsilon 1 "GO:0000226,GO:0000242,GO:0000278,GO:0003924,GO:0005200,GO:0005525,GO:0005737,GO:0005874,GO:0007098" microtubule cytoskeleton organization|pericentriolar material|mitotic cell cycle|GTPase activity|structural constituent of cytoskeleton|GTP binding|cytoplasm|microtubule|centrosome cycle TUBG1 2923.606594 2757.096789 3090.116399 1.120786333 0.164511268 0.487337795 1 77.40199279 85.29943353 7283 tubulin gamma 1 "GO:0000070,GO:0000086,GO:0000212,GO:0000226,GO:0000278,GO:0000794,GO:0000930,GO:0003924,GO:0005200,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005813,GO:0005819,GO:0005827,GO:0005829,GO:0005874,GO:0007020,GO:0007052,GO:0010389,GO:0031122,GO:0042802,GO:0055037,GO:0097711,GO:1990498" mitotic sister chromatid segregation|G2/M transition of mitotic cell cycle|meiotic spindle organization|microtubule cytoskeleton organization|mitotic cell cycle|condensed nuclear chromosome|gamma-tubulin complex|GTPase activity|structural constituent of cytoskeleton|protein binding|GTP binding|nucleus|cytoplasm|centrosome|spindle|polar microtubule|cytosol|microtubule|microtubule nucleation|mitotic spindle organization|regulation of G2/M transition of mitotic cell cycle|cytoplasmic microtubule organization|identical protein binding|recycling endosome|ciliary basal body-plasma membrane docking|mitotic spindle microtubule hsa05165 Human papillomavirus infection TUBG2 1081.07101 1066.42423 1095.71779 1.027468956 0.039094805 0.876469667 1 26.92199675 27.19863789 27175 tubulin gamma 2 "GO:0000070,GO:0000212,GO:0000226,GO:0000242,GO:0000278,GO:0000930,GO:0003924,GO:0005198,GO:0005200,GO:0005525,GO:0005634,GO:0005737,GO:0005813,GO:0005819,GO:0005829,GO:0005874,GO:0005876,GO:0005881,GO:0007020,GO:0007052,GO:0015630,GO:0031122" mitotic sister chromatid segregation|meiotic spindle organization|microtubule cytoskeleton organization|pericentriolar material|mitotic cell cycle|gamma-tubulin complex|GTPase activity|structural molecule activity|structural constituent of cytoskeleton|GTP binding|nucleus|cytoplasm|centrosome|spindle|cytosol|microtubule|spindle microtubule|cytoplasmic microtubule|microtubule nucleation|mitotic spindle organization|microtubule cytoskeleton|cytoplasmic microtubule organization hsa05165 Human papillomavirus infection TUBGCP2 1252.453066 1225.607554 1279.298577 1.04380768 0.061855922 0.800493654 1 16.29913346 16.72846848 10844 tubulin gamma complex associated protein 2 "GO:0000278,GO:0000922,GO:0000923,GO:0000930,GO:0001764,GO:0005515,GO:0005654,GO:0005813,GO:0005815,GO:0005829,GO:0005881,GO:0007020,GO:0007420,GO:0008275,GO:0016020,GO:0031122,GO:0043015,GO:0051011,GO:0051225,GO:0051321,GO:0065003" mitotic cell cycle|spindle pole|equatorial microtubule organizing center|gamma-tubulin complex|neuron migration|protein binding|nucleoplasm|centrosome|microtubule organizing center|cytosol|cytoplasmic microtubule|microtubule nucleation|brain development|gamma-tubulin small complex|membrane|cytoplasmic microtubule organization|gamma-tubulin binding|microtubule minus-end binding|spindle assembly|meiotic cell cycle|protein-containing complex assembly TUBGCP3 1035.024843 1043.535124 1026.514561 0.983689516 -0.023725069 0.92699634 1 9.633549844 9.317846892 10426 tubulin gamma complex associated protein 3 "GO:0000278,GO:0000923,GO:0000930,GO:0005198,GO:0005200,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0005819,GO:0005827,GO:0005829,GO:0007020,GO:0007338,GO:0008275,GO:0016020,GO:0031122,GO:0043015,GO:0051011,GO:0051225,GO:0051321" mitotic cell cycle|equatorial microtubule organizing center|gamma-tubulin complex|structural molecule activity|structural constituent of cytoskeleton|protein binding|cytoplasm|centrosome|centriole|spindle|polar microtubule|cytosol|microtubule nucleation|single fertilization|gamma-tubulin small complex|membrane|cytoplasmic microtubule organization|gamma-tubulin binding|microtubule minus-end binding|spindle assembly|meiotic cell cycle TUBGCP4 647.5525022 661.7032294 633.401775 0.957229385 -0.06306341 0.813135964 1 5.124638687 4.823368595 27229 tubulin gamma complex associated protein 4 "GO:0000278,GO:0000922,GO:0000923,GO:0000930,GO:0005200,GO:0005515,GO:0005813,GO:0005829,GO:0005874,GO:0007020,GO:0008274,GO:0015630,GO:0016020,GO:0031122,GO:0043015,GO:0051011,GO:0051225,GO:0051321,GO:0055037,GO:0065003" mitotic cell cycle|spindle pole|equatorial microtubule organizing center|gamma-tubulin complex|structural constituent of cytoskeleton|protein binding|centrosome|cytosol|microtubule|microtubule nucleation|gamma-tubulin ring complex|microtubule cytoskeleton|membrane|cytoplasmic microtubule organization|gamma-tubulin binding|microtubule minus-end binding|spindle assembly|meiotic cell cycle|recycling endosome|protein-containing complex assembly TUBGCP5 388.4334964 381.8318949 395.0350979 1.034578575 0.049043221 0.875094536 1 3.539018141 3.600123904 114791 tubulin gamma complex associated protein 5 "GO:0000278,GO:0000922,GO:0000923,GO:0000930,GO:0005515,GO:0005813,GO:0005829,GO:0005874,GO:0007020,GO:0008017,GO:0008274,GO:0031122,GO:0043015,GO:0051011,GO:0051225,GO:0051321" mitotic cell cycle|spindle pole|equatorial microtubule organizing center|gamma-tubulin complex|protein binding|centrosome|cytosol|microtubule|microtubule nucleation|microtubule binding|gamma-tubulin ring complex|cytoplasmic microtubule organization|gamma-tubulin binding|microtubule minus-end binding|spindle assembly|meiotic cell cycle TUBGCP6 987.0664244 995.6760857 978.4567632 0.982705899 -0.025168378 0.922823956 1 8.75987516 8.464331399 85378 tubulin gamma complex associated protein 6 "GO:0000278,GO:0000922,GO:0000923,GO:0000930,GO:0005813,GO:0005829,GO:0005874,GO:0007020,GO:0008017,GO:0008274,GO:0008275,GO:0016020,GO:0031122,GO:0043015,GO:0051011,GO:0051225,GO:0051321" mitotic cell cycle|spindle pole|equatorial microtubule organizing center|gamma-tubulin complex|centrosome|cytosol|microtubule|microtubule nucleation|microtubule binding|gamma-tubulin ring complex|gamma-tubulin small complex|membrane|cytoplasmic microtubule organization|gamma-tubulin binding|microtubule minus-end binding|spindle assembly|meiotic cell cycle TUFM 4097.071878 3915.07744 4279.066316 1.092971054 0.128255193 0.590832086 1 103.8988003 111.6581355 7284 "Tu translation elongation factor, mitochondrial" "GO:0003723,GO:0003746,GO:0003924,GO:0005515,GO:0005525,GO:0005739,GO:0006414,GO:0016020,GO:0016032,GO:0042645,GO:0045202,GO:0045471,GO:0070062,GO:0070125" RNA binding|translation elongation factor activity|GTPase activity|protein binding|GTP binding|mitochondrion|translational elongation|membrane|viral process|mitochondrial nucleoid|synapse|response to ethanol|extracellular exosome|mitochondrial translational elongation TUFT1 497.6970758 550.3789439 445.0152076 0.808561469 -0.306570639 0.262965242 1 8.0363099 6.389117812 7286 tuftelin 1 "GO:0005515,GO:0005576,GO:0005622,GO:0005737,GO:0030282,GO:0030345,GO:0035556,GO:0042476" protein binding|extracellular region|intracellular anatomical structure|cytoplasm|bone mineralization|structural constituent of tooth enamel|intracellular signal transduction|odontogenesis TULP3 780.3448952 779.2699981 781.4197922 1.002758728 0.003974524 0.993258836 1 21.05732028 20.76207389 7289 TUB like protein 3 "GO:0001664,GO:0001843,GO:0005515,GO:0005546,GO:0005576,GO:0005634,GO:0005654,GO:0005730,GO:0005886,GO:0005929,GO:0005930,GO:0006355,GO:0007186,GO:0007420,GO:0008277,GO:0009952,GO:0019899,GO:0021914,GO:0021953,GO:0031076,GO:0035091,GO:0042733,GO:0044877,GO:0045879,GO:0048702,GO:0060348,GO:0060434,GO:0060831,GO:0061512,GO:0061548,GO:0097546,GO:0097731,GO:0120160,GO:1901621" "G protein-coupled receptor binding|neural tube closure|protein binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular region|nucleus|nucleoplasm|nucleolus|plasma membrane|cilium|axoneme|regulation of transcription, DNA-templated|G protein-coupled receptor signaling pathway|brain development|regulation of G protein-coupled receptor signaling pathway|anterior/posterior pattern specification|enzyme binding|negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning|central nervous system neuron differentiation|embryonic camera-type eye development|phosphatidylinositol binding|embryonic digit morphogenesis|protein-containing complex binding|negative regulation of smoothened signaling pathway|embryonic neurocranium morphogenesis|bone development|bronchus morphogenesis|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|protein localization to cilium|ganglion development|ciliary base|9+0 non-motile cilium|intraciliary transport particle A binding|negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" TULP4 359.4151498 440.0950724 278.7352272 0.633352302 -0.658919873 0.026985269 0.873268385 1.978857962 1.232341729 56995 TUB like protein 4 "GO:0005737,GO:0005829,GO:0016567,GO:0043687" cytoplasm|cytosol|protein ubiquitination|post-translational protein modification TUSC1 324.7348918 337.094098 312.3756857 0.92667207 -0.109869205 0.728019803 1 12.18840952 11.10565787 286319 tumor suppressor candidate 1 TUSC2 420.1019532 405.7614142 434.4424921 1.070684587 0.098533539 0.736357298 1 12.97468 13.6593296 11334 "tumor suppressor 2, mitochondrial calcium regulator" "GO:0001779,GO:0005515,GO:0005739,GO:0006909,GO:0006954,GO:0007049,GO:0032700,GO:0032733,GO:0048469,GO:0051881,GO:0070945,GO:2000377" natural killer cell differentiation|protein binding|mitochondrion|phagocytosis|inflammatory response|cell cycle|negative regulation of interleukin-17 production|positive regulation of interleukin-10 production|cell maturation|regulation of mitochondrial membrane potential|neutrophil-mediated killing of gram-negative bacterium|regulation of reactive oxygen species metabolic process TUSC3 2055.896501 1829.047606 2282.745395 1.248051384 0.319677333 0.176621197 1 10.41093313 12.7759529 7991 tumor suppressor candidate 3 "GO:0005739,GO:0005789,GO:0005886,GO:0005887,GO:0006487,GO:0008250,GO:0015095,GO:0015693,GO:0018279,GO:0050890,GO:0055085,GO:1903830" mitochondrion|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|protein N-linked glycosylation|oligosaccharyltransferase complex|magnesium ion transmembrane transporter activity|magnesium ion transport|protein N-linked glycosylation via asparagine|cognition|transmembrane transport|magnesium ion transmembrane transport "hsa00510,hsa00513,hsa04141" N-Glycan biosynthesis|Various types of N-glycan biosynthesis|Protein processing in endoplasmic reticulum TUT1 586.9606624 559.7426689 614.1786559 1.097251809 0.133894648 0.61585213 1 11.04341496 11.91463865 64852 "terminal uridylyl transferase 1, U6 snRNA-specific" "GO:0003723,GO:0003730,GO:0004652,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005847,GO:0006378,GO:0006397,GO:0016180,GO:0016607,GO:0016779,GO:0017070,GO:0019899,GO:0034477,GO:0046872,GO:0050265,GO:0071044,GO:0098789" RNA binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|mRNA cleavage and polyadenylation specificity factor complex|mRNA polyadenylation|mRNA processing|snRNA processing|nuclear speck|nucleotidyltransferase activity|U6 snRNA binding|enzyme binding|U6 snRNA 3'-end processing|metal ion binding|RNA uridylyltransferase activity|histone mRNA catabolic process|pre-mRNA cleavage required for polyadenylation TUT4 1310.745811 1368.144256 1253.347367 0.916092993 -0.12643404 0.600683133 1 10.17210147 9.16265689 23318 terminal uridylyl transferase 4 "GO:0000289,GO:0001556,GO:0003723,GO:0004652,GO:0005515,GO:0005615,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0006378,GO:0006397,GO:0008270,GO:0010526,GO:0010586,GO:0010587,GO:0016779,GO:0019827,GO:0031054,GO:0031123,GO:0035198,GO:0036464,GO:0050265,GO:0070062,GO:0071044,GO:0071076,GO:1990074" "nuclear-transcribed mRNA poly(A) tail shortening|oocyte maturation|RNA binding|polynucleotide adenylyltransferase activity|protein binding|extracellular space|nucleus|nucleolus|cytoplasm|cytosol|mRNA polyadenylation|mRNA processing|zinc ion binding|negative regulation of transposition, RNA-mediated|miRNA metabolic process|miRNA catabolic process|nucleotidyltransferase activity|stem cell population maintenance|pre-miRNA processing|RNA 3'-end processing|miRNA binding|cytoplasmic ribonucleoprotein granule|RNA uridylyltransferase activity|extracellular exosome|histone mRNA catabolic process|RNA 3' uridylation|polyuridylation-dependent mRNA catabolic process" TUT7 1196.804785 1278.668662 1114.940909 0.871954512 -0.19767522 0.415084932 1 6.121294975 5.248175093 79670 terminal uridylyl transferase 7 "GO:0000289,GO:0001556,GO:0003723,GO:0004652,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006378,GO:0006397,GO:0008270,GO:0010526,GO:0010586,GO:0016779,GO:0031054,GO:0031123,GO:0035198,GO:0050265,GO:0070569,GO:0071044,GO:0071076,GO:1990074" "nuclear-transcribed mRNA poly(A) tail shortening|oocyte maturation|RNA binding|polynucleotide adenylyltransferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|mRNA polyadenylation|mRNA processing|zinc ion binding|negative regulation of transposition, RNA-mediated|miRNA metabolic process|nucleotidyltransferase activity|pre-miRNA processing|RNA 3'-end processing|miRNA binding|RNA uridylyltransferase activity|uridylyltransferase activity|histone mRNA catabolic process|RNA 3' uridylation|polyuridylation-dependent mRNA catabolic process" TVP23B 634.8744212 619.0462602 650.7025822 1.051137248 0.071951055 0.787327123 1 10.40546808 10.75454957 51030 trans-golgi network vesicle protein 23 homolog B "GO:0005515,GO:0009306,GO:0016192,GO:0030173" protein binding|protein secretion|vesicle-mediated transport|integral component of Golgi membrane TVP23C 88.51505233 78.0310412 98.99906347 1.26871386 0.343366727 0.491056275 1 0.824955082 1.029117978 201158 trans-golgi network vesicle protein 23 homolog C "GO:0009306,GO:0016192,GO:0030173" protein secretion|vesicle-mediated transport|integral component of Golgi membrane TWF1 3251.340039 2907.956802 3594.723275 1.236168045 0.305874877 0.196963438 1 51.59318814 62.71061457 5756 twinfilin actin binding protein 1 "GO:0003779,GO:0003785,GO:0004713,GO:0005515,GO:0005524,GO:0005546,GO:0005730,GO:0005737,GO:0005829,GO:0005884,GO:0005911,GO:0005925,GO:0010591,GO:0010976,GO:0015629,GO:0018108,GO:0030016,GO:0030042,GO:0030175,GO:0030837,GO:0032587,GO:0042989,GO:0043538,GO:0045296,GO:0048471,GO:0051015,GO:0051016" "actin binding|actin monomer binding|protein tyrosine kinase activity|protein binding|ATP binding|phosphatidylinositol-4,5-bisphosphate binding|nucleolus|cytoplasm|cytosol|actin filament|cell-cell junction|focal adhesion|regulation of lamellipodium assembly|positive regulation of neuron projection development|actin cytoskeleton|peptidyl-tyrosine phosphorylation|myofibril|actin filament depolymerization|filopodium|negative regulation of actin filament polymerization|ruffle membrane|sequestering of actin monomers|regulation of actin phosphorylation|cadherin binding|perinuclear region of cytoplasm|actin filament binding|barbed-end actin filament capping" TWF2 2637.144333 2453.295935 2820.992731 1.149878696 0.201481675 0.394392721 1 81.12013327 91.71742682 11344 twinfilin actin binding protein 2 "GO:0003723,GO:0003785,GO:0005080,GO:0005515,GO:0005524,GO:0005546,GO:0005737,GO:0005884,GO:0010591,GO:0010592,GO:0010976,GO:0030016,GO:0030027,GO:0030030,GO:0030042,GO:0030175,GO:0030426,GO:0030837,GO:0032420,GO:0032532,GO:0032956,GO:0042989,GO:0045296,GO:0045773,GO:0048471,GO:0051015,GO:0051016,GO:0070062,GO:0071300,GO:0071363" "RNA binding|actin monomer binding|protein kinase C binding|protein binding|ATP binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|actin filament|regulation of lamellipodium assembly|positive regulation of lamellipodium assembly|positive regulation of neuron projection development|myofibril|lamellipodium|cell projection organization|actin filament depolymerization|filopodium|growth cone|negative regulation of actin filament polymerization|stereocilium|regulation of microvillus length|regulation of actin cytoskeleton organization|sequestering of actin monomers|cadherin binding|positive regulation of axon extension|perinuclear region of cytoplasm|actin filament binding|barbed-end actin filament capping|extracellular exosome|cellular response to retinoic acid|cellular response to growth factor stimulus" TWNK 418.2683456 483.7924554 352.7442358 0.729123061 -0.455765763 0.110454658 1 14.53778951 10.42246366 56652 twinkle mtDNA helicase "GO:0002020,GO:0003678,GO:0003697,GO:0005524,GO:0005739,GO:0005759,GO:0006264,GO:0006268,GO:0006390,GO:0007005,GO:0034214,GO:0042645,GO:0042802,GO:0043139,GO:0071333" protease binding|DNA helicase activity|single-stranded DNA binding|ATP binding|mitochondrion|mitochondrial matrix|mitochondrial DNA replication|DNA unwinding involved in DNA replication|mitochondrial transcription|mitochondrion organization|protein hexamerization|mitochondrial nucleoid|identical protein binding|5'-3' DNA helicase activity|cellular response to glucose stimulus hsa05017 Spinocerebellar ataxia TWSG1 2710.36395 2722.763131 2697.964768 0.990892207 -0.01319997 0.957166476 1 38.74903042 37.75360534 57045 twisted gastrulation BMP signaling modulator 1 "GO:0001503,GO:0001707,GO:0001818,GO:0005515,GO:0005615,GO:0007179,GO:0007435,GO:0010862,GO:0030097,GO:0030154,GO:0030509,GO:0030510,GO:0030513,GO:0030514,GO:0030900,GO:0043010,GO:0045668,GO:0050431,GO:2000515,GO:2000562" "ossification|mesoderm formation|negative regulation of cytokine production|protein binding|extracellular space|transforming growth factor beta receptor signaling pathway|salivary gland morphogenesis|positive regulation of pathway-restricted SMAD protein phosphorylation|hemopoiesis|cell differentiation|BMP signaling pathway|regulation of BMP signaling pathway|positive regulation of BMP signaling pathway|negative regulation of BMP signaling pathway|forebrain development|camera-type eye development|negative regulation of osteoblast differentiation|transforming growth factor beta binding|negative regulation of CD4-positive, alpha-beta T cell activation|negative regulation of CD4-positive, alpha-beta T cell proliferation" TXK 90.38264403 114.4455271 66.31976096 0.579487575 -0.787150367 0.104278456 1 1.025650284 0.584405927 7294 TXK tyrosine kinase "GO:0001816,GO:0002250,GO:0004715,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005886,GO:0006468,GO:0007202,GO:0007229,GO:0010468,GO:0010543,GO:0032729,GO:0038083,GO:0042246,GO:0045944,GO:0046777,GO:0050852,GO:0060335" cytokine production|adaptive immune response|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|plasma membrane|protein phosphorylation|activation of phospholipase C activity|integrin-mediated signaling pathway|regulation of gene expression|regulation of platelet activation|positive regulation of interferon-gamma production|peptidyl-tyrosine autophosphorylation|tissue regeneration|positive regulation of transcription by RNA polymerase II|protein autophosphorylation|T cell receptor signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway hsa04670 Leukocyte transendothelial migration TXLNA 1674.867976 1755.17822 1594.557731 0.908487647 -0.138461197 0.56105463 1 18.02398224 16.10055904 200081 taxilin alpha "GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0006887,GO:0016020,GO:0019221,GO:0019905,GO:0042113" protein binding|extracellular region|cytoplasm|cytosol|exocytosis|membrane|cytokine-mediated signaling pathway|syntaxin binding|B cell activation TXLNG 1137.381693 1257.860384 1016.903001 0.80843869 -0.306789727 0.207056076 1 7.1111967 5.652765377 55787 taxilin gamma "GO:0005829,GO:0007049,GO:0008134,GO:0010564,GO:0019905,GO:0030500,GO:0031965,GO:0033613,GO:0051726" cytosol|cell cycle|transcription factor binding|regulation of cell cycle process|syntaxin binding|regulation of bone mineralization|nuclear membrane|activating transcription factor binding|regulation of cell cycle TXN 4913.393382 4263.616091 5563.170673 1.304801031 0.383829828 0.109790008 1 308.7399655 396.1031729 7295 thioredoxin "GO:0000122,GO:0003723,GO:0004791,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006662,GO:0009314,GO:0015035,GO:0015037,GO:0032148,GO:0033138,GO:0042803,GO:0043388,GO:0045454,GO:0046826,GO:0047134,GO:0051897,GO:0055114,GO:0070062,GO:0071731,GO:0098869,GO:1903206,GO:2000170" negative regulation of transcription by RNA polymerase II|RNA binding|thioredoxin-disulfide reductase activity|protein binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|glycerol ether metabolic process|response to radiation|protein disulfide oxidoreductase activity|peptide disulfide oxidoreductase activity|activation of protein kinase B activity|positive regulation of peptidyl-serine phosphorylation|protein homodimerization activity|positive regulation of DNA binding|cell redox homeostasis|negative regulation of protein export from nucleus|protein-disulfide reductase activity|positive regulation of protein kinase B signaling|oxidation-reduction process|extracellular exosome|response to nitric oxide|cellular oxidant detoxification|negative regulation of hydrogen peroxide-induced cell death|positive regulation of peptidyl-cysteine S-nitrosylation "hsa04621,hsa05012,hsa05132,hsa05418" NOD-like receptor signaling pathway|Parkinson disease|Salmonella infection|Fluid shear stress and atherosclerosis TXN2 1109.484861 1017.524777 1201.444945 1.18075252 0.239706615 0.32570162 1 35.17061349 40.83287918 25828 thioredoxin 2 "GO:0000098,GO:0001666,GO:0005515,GO:0005730,GO:0005739,GO:0005759,GO:0006662,GO:0006979,GO:0008113,GO:0009725,GO:0009749,GO:0014070,GO:0015035,GO:0030425,GO:0031669,GO:0033743,GO:0042493,GO:0043025,GO:0044877,GO:0045454,GO:0048678,GO:0055114" sulfur amino acid catabolic process|response to hypoxia|protein binding|nucleolus|mitochondrion|mitochondrial matrix|glycerol ether metabolic process|response to oxidative stress|peptide-methionine (S)-S-oxide reductase activity|response to hormone|response to glucose|response to organic cyclic compound|protein disulfide oxidoreductase activity|dendrite|cellular response to nutrient levels|peptide-methionine (R)-S-oxide reductase activity|response to drug|neuronal cell body|protein-containing complex binding|cell redox homeostasis|response to axon injury|oxidation-reduction process "hsa04621,hsa05012,hsa05132,hsa05418" NOD-like receptor signaling pathway|Parkinson disease|Salmonella infection|Fluid shear stress and atherosclerosis TXNDC11 634.8347922 618.0058463 651.6637382 1.054462093 0.076507232 0.773791481 1 9.934288003 10.30003966 51061 thioredoxin domain containing 11 "GO:0005515,GO:0005789,GO:0016021" protein binding|endoplasmic reticulum membrane|integral component of membrane TXNDC12 1968.816923 1965.341824 1972.292022 1.003536381 0.005092919 0.985264079 1 74.07251484 73.0905769 51060 thioredoxin domain containing 12 "GO:0005515,GO:0005783,GO:0005788,GO:0015037,GO:0019153,GO:0055114,GO:0060548,GO:1902236" protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|peptide disulfide oxidoreductase activity|protein-disulfide reductase (glutathione) activity|oxidation-reduction process|negative regulation of cell death|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway hsa00480 Glutathione metabolism TXNDC15 807.2962765 881.2305586 733.3619944 0.832202183 -0.264994022 0.29216148 1 12.74171099 10.42624148 79770 thioredoxin domain containing 15 "GO:0005515,GO:0005929,GO:0016021,GO:0045880,GO:0060170,GO:0060271" protein binding|cilium|integral component of membrane|positive regulation of smoothened signaling pathway|ciliary membrane|cilium assembly TXNDC16 273.5759741 280.9117483 266.2401998 0.947771681 -0.077388541 0.821928932 1 3.178236954 2.961837173 57544 thioredoxin domain containing 16 "GO:0005515,GO:0005788,GO:0008150,GO:0070062" protein binding|endoplasmic reticulum lumen|biological_process|extracellular exosome TXNDC17 467.6936499 469.2266611 466.1606387 0.993465797 -0.009457796 0.981505561 1 13.06299661 12.7604771 84817 thioredoxin domain containing 17 "GO:0004601,GO:0005515,GO:0005829,GO:0033209,GO:0047134,GO:0055114,GO:0070062,GO:0098869" peroxidase activity|protein binding|cytosol|tumor necrosis factor-mediated signaling pathway|protein-disulfide reductase activity|oxidation-reduction process|extracellular exosome|cellular oxidant detoxification TXNDC5 5147.424298 5184.382377 5110.466218 0.985742533 -0.020717218 0.932122136 1 86.38181673 83.72535705 81567 thioredoxin domain containing 5 "GO:0003756,GO:0005515,GO:0005576,GO:0005783,GO:0005788,GO:0018215,GO:0035578,GO:0043066,GO:0043202,GO:0043277,GO:0043312,GO:0070062" protein disulfide isomerase activity|protein binding|extracellular region|endoplasmic reticulum|endoplasmic reticulum lumen|protein phosphopantetheinylation|azurophil granule lumen|negative regulation of apoptotic process|lysosomal lumen|apoptotic cell clearance|neutrophil degranulation|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum TXNDC9 946.2430628 832.3311061 1060.155019 1.273717889 0.349045776 0.15785109 1 21.05212387 26.36576299 10190 thioredoxin domain containing 9 "GO:0005515,GO:0005634,GO:0005813,GO:0005829,GO:0008150,GO:0030496,GO:0045296" protein binding|nucleus|centrosome|cytosol|biological_process|midbody|cadherin binding TXNIP 3132.973318 3863.056746 2402.88989 0.622017756 -0.68497233 0.003944824 0.388096891 64.97454729 39.73902644 10628 thioredoxin interacting protein "GO:0000122,GO:0004857,GO:0005515,GO:0005634,GO:0005737,GO:0005758,GO:0005829,GO:0006606,GO:0007049,GO:0009612,GO:0009749,GO:0015031,GO:0030216,GO:0031625,GO:0032355,GO:0032570,GO:0042127,GO:0042493,GO:0042542,GO:0043065,GO:0043086,GO:0048008,GO:0051592,GO:0051782,GO:0071228" negative regulation of transcription by RNA polymerase II|enzyme inhibitor activity|protein binding|nucleus|cytoplasm|mitochondrial intermembrane space|cytosol|protein import into nucleus|cell cycle|response to mechanical stimulus|response to glucose|protein transport|keratinocyte differentiation|ubiquitin protein ligase binding|response to estradiol|response to progesterone|regulation of cell population proliferation|response to drug|response to hydrogen peroxide|positive regulation of apoptotic process|negative regulation of catalytic activity|platelet-derived growth factor receptor signaling pathway|response to calcium ion|negative regulation of cell division|cellular response to tumor cell hsa04621 NOD-like receptor signaling pathway TXNL1 1542.978217 1484.670611 1601.285823 1.078546185 0.109087956 0.648727402 1 10.29549659 10.91835535 9352 thioredoxin like 1 "GO:0000502,GO:0005634,GO:0005737,GO:0005829,GO:0015036,GO:0055114" proteasome complex|nucleus|cytoplasm|cytosol|disulfide oxidoreductase activity|oxidation-reduction process TXNL4A 1051.63245 974.867808 1128.397092 1.157487285 0.210996346 0.389450649 1 13.82223783 15.73134186 10907 thioredoxin like 4A "GO:0000245,GO:0000375,GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0005829,GO:0007049,GO:0031965,GO:0046540,GO:0051301,GO:0071005" "spliceosomal complex assembly|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|spliceosomal complex|U5 snRNP|cytosol|cell cycle|nuclear membrane|U4/U6 x U5 tri-snRNP complex|cell division|U2-type precatalytic spliceosome" hsa03040 Spliceosome TXNL4B 329.5010427 336.0536841 322.9484012 0.961002413 -0.057388042 0.860591577 1 5.753791299 5.436880178 54957 thioredoxin like 4B "GO:0000398,GO:0005515,GO:0005654,GO:0005681,GO:0005682,GO:0005829,GO:0007049,GO:0046540" "mRNA splicing, via spliceosome|protein binding|nucleoplasm|spliceosomal complex|U5 snRNP|cytosol|cell cycle|U4/U6 x U5 tri-snRNP complex" TXNRD1 33393.35598 27048.68012 39738.03184 1.469130163 0.554962223 0.064752146 1 366.5663648 529.5220712 7296 thioredoxin reductase 1 "GO:0001650,GO:0001707,GO:0001887,GO:0004791,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0007165,GO:0008283,GO:0015035,GO:0015949,GO:0019216,GO:0034599,GO:0045454,GO:0050660,GO:0055114,GO:0070062,GO:0098869" fibrillar center|mesoderm formation|selenium compound metabolic process|thioredoxin-disulfide reductase activity|protein binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|signal transduction|cell population proliferation|protein disulfide oxidoreductase activity|nucleobase-containing small molecule interconversion|regulation of lipid metabolic process|cellular response to oxidative stress|cell redox homeostasis|flavin adenine dinucleotide binding|oxidation-reduction process|extracellular exosome|cellular oxidant detoxification "hsa00450,hsa05200,hsa05225" Selenocompound metabolism|Pathways in cancer|Hepatocellular carcinoma TXNRD2 812.0133519 803.1995174 820.8271864 1.021946812 0.031320112 0.905775569 1 11.51982855 11.57565267 10587 thioredoxin reductase 2 "GO:0000305,GO:0004791,GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0034599,GO:0043231,GO:0045454,GO:0050660,GO:0055114,GO:0098869" response to oxygen radical|thioredoxin-disulfide reductase activity|protein binding|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|cellular response to oxidative stress|intracellular membrane-bounded organelle|cell redox homeostasis|flavin adenine dinucleotide binding|oxidation-reduction process|cellular oxidant detoxification "hsa00450,hsa05200,hsa05225" Selenocompound metabolism|Pathways in cancer|Hepatocellular carcinoma TXNRD3 194.5636552 174.7895323 214.3377782 1.226262096 0.294267367 0.427318004 1 3.193494039 3.850530721 114112 thioredoxin reductase 3 "GO:0004791,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0007275,GO:0007283,GO:0015035,GO:0030154,GO:0045454,GO:0050660,GO:0055114,GO:0098869" thioredoxin-disulfide reductase activity|protein binding|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|multicellular organism development|spermatogenesis|protein disulfide oxidoreductase activity|cell differentiation|cell redox homeostasis|flavin adenine dinucleotide binding|oxidation-reduction process|cellular oxidant detoxification "hsa00450,hsa05200,hsa05225" Selenocompound metabolism|Pathways in cancer|Hepatocellular carcinoma TYK2 1352.521497 1354.618875 1350.424118 0.996903367 -0.004474428 0.988621817 1 14.29573259 14.012985 7297 tyrosine kinase 2 "GO:0004713,GO:0004715,GO:0005131,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0006468,GO:0016020,GO:0018108,GO:0019221,GO:0031702,GO:0035556,GO:0035722,GO:0038155,GO:0060337,GO:0070062,GO:0070106" protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|growth hormone receptor binding|protein binding|ATP binding|nucleus|cytoplasm|cytosol|cytoskeleton|protein phosphorylation|membrane|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|type 1 angiotensin receptor binding|intracellular signal transduction|interleukin-12-mediated signaling pathway|interleukin-23-mediated signaling pathway|type I interferon signaling pathway|extracellular exosome|interleukin-27-mediated signaling pathway "hsa04217,hsa04380,hsa04621,hsa04630,hsa04658,hsa04659,hsa05145,hsa05160,hsa05161,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05171" Necroptosis|Osteoclast differentiation|NOD-like receptor signaling pathway|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Toxoplasmosis|Hepatitis C|Hepatitis B|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 TYMP 342.2093062 303.8008537 380.6177586 1.252852827 0.325216951 0.283275984 1 9.160052656 11.28415924 1890 thymidine phosphorylase "GO:0000002,GO:0001525,GO:0004645,GO:0005515,GO:0005829,GO:0006206,GO:0006213,GO:0006935,GO:0007165,GO:0008083,GO:0009032,GO:0016154,GO:0030154,GO:0031641,GO:0042803,GO:0043097,GO:0046074,GO:0046135,GO:0051969,GO:1905333" "mitochondrial genome maintenance|angiogenesis|1,4-alpha-oligoglucan phosphorylase activity|protein binding|cytosol|pyrimidine nucleobase metabolic process|pyrimidine nucleoside metabolic process|chemotaxis|signal transduction|growth factor activity|thymidine phosphorylase activity|pyrimidine-nucleoside phosphorylase activity|cell differentiation|regulation of myelination|protein homodimerization activity|pyrimidine nucleoside salvage|dTMP catabolic process|pyrimidine nucleoside catabolic process|regulation of transmission of nerve impulse|regulation of gastric motility" "hsa00240,hsa00983,hsa05219" Pyrimidine metabolism|Drug metabolism - other enzymes|Bladder cancer TYMS 2902.051625 2481.38711 3322.71614 1.339055936 0.421216227 0.075271228 1 76.99248225 101.3720477 7298 thymidylate synthetase "GO:0000083,GO:0000900,GO:0004799,GO:0005542,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005743,GO:0005759,GO:0005829,GO:0006231,GO:0006235,GO:0007568,GO:0007623,GO:0008144,GO:0009636,GO:0015949,GO:0017148,GO:0019048,GO:0019860,GO:0032259,GO:0032570,GO:0033189,GO:0034097,GO:0035999,GO:0042493,GO:0042803,GO:0045471,GO:0046683,GO:0048589,GO:0051216,GO:0051384,GO:0051593,GO:0060574,GO:0071897,GO:0097421,GO:1990825" "regulation of transcription involved in G1/S transition of mitotic cell cycle|translation repressor activity, mRNA regulatory element binding|thymidylate synthase activity|folic acid binding|nucleus|nucleolus|cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|cytosol|dTMP biosynthetic process|dTTP biosynthetic process|aging|circadian rhythm|drug binding|response to toxic substance|nucleobase-containing small molecule interconversion|negative regulation of translation|modulation by virus of host process|uracil metabolic process|methylation|response to progesterone|response to vitamin A|response to cytokine|tetrahydrofolate interconversion|response to drug|protein homodimerization activity|response to ethanol|response to organophosphorus|developmental growth|cartilage development|response to glucocorticoid|response to folic acid|intestinal epithelial cell maturation|DNA biosynthetic process|liver regeneration|sequence-specific mRNA binding" "hsa00240,hsa00670,hsa01523" Pyrimidine metabolism|One carbon pool by folate|Antifolate resistance TYRO3 559.9344391 544.1364606 575.7324176 1.058066238 0.081429947 0.765477604 1 2.785569575 2.89799776 7301 TYRO3 protein tyrosine kinase "GO:0001618,GO:0001779,GO:0004713,GO:0004714,GO:0005515,GO:0005524,GO:0005634,GO:0005635,GO:0005789,GO:0005887,GO:0006909,GO:0007155,GO:0007165,GO:0007169,GO:0007218,GO:0007275,GO:0007283,GO:0007399,GO:0009986,GO:0014065,GO:0016477,GO:0018108,GO:0021885,GO:0030168,GO:0032940,GO:0033674,GO:0034122,GO:0034446,GO:0042698,GO:0043235,GO:0043277,GO:0043491,GO:0043524,GO:0043548,GO:0045824,GO:0046718,GO:0046777,GO:0050728,GO:0051250,GO:0060068,GO:0070050,GO:0070527,GO:1903902" virus receptor activity|natural killer cell differentiation|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nuclear envelope|endoplasmic reticulum membrane|integral component of plasma membrane|phagocytosis|cell adhesion|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|neuropeptide signaling pathway|multicellular organism development|spermatogenesis|nervous system development|cell surface|phosphatidylinositol 3-kinase signaling|cell migration|peptidyl-tyrosine phosphorylation|forebrain cell migration|platelet activation|secretion by cell|positive regulation of kinase activity|negative regulation of toll-like receptor signaling pathway|substrate adhesion-dependent cell spreading|ovulation cycle|receptor complex|apoptotic cell clearance|protein kinase B signaling|negative regulation of neuron apoptotic process|phosphatidylinositol 3-kinase binding|negative regulation of innate immune response|viral entry into host cell|protein autophosphorylation|negative regulation of inflammatory response|negative regulation of lymphocyte activation|vagina development|neuron cellular homeostasis|platelet aggregation|positive regulation of viral life cycle TYSND1 369.7356147 370.3873422 369.0838871 0.996480832 -0.00508604 0.996764988 1 5.259949897 5.153730864 219743 trypsin like peroxisomal matrix peptidase 1 "GO:0002020,GO:0004252,GO:0005777,GO:0005782,GO:0005829,GO:0006508,GO:0006625,GO:0016020,GO:0016485,GO:0031998" protease binding|serine-type endopeptidase activity|peroxisome|peroxisomal matrix|cytosol|proteolysis|protein targeting to peroxisome|membrane|protein processing|regulation of fatty acid beta-oxidation TYW1 255.1259269 250.7397457 259.5121081 1.034985927 0.049611151 0.893358479 1 1.984799672 2.019864808 55253 tRNA-yW synthesizing protein 1 homolog "GO:0010181,GO:0031591,GO:0046872,GO:0051539,GO:0055114,GO:0102521" "FMN binding|wybutosine biosynthetic process|metal ion binding|4 iron, 4 sulfur cluster binding|oxidation-reduction process|tRNA-4-demethylwyosine synthase activity" TYW1B 12.37111012 9.363724944 15.3784953 1.642348039 0.715759889 0.526718487 1 0.160322358 0.258899056 441250 tRNA-yW synthesizing protein 1 homolog B "GO:0005515,GO:0010181,GO:0031591,GO:0046872,GO:0051539,GO:0055114,GO:0102521" "protein binding|FMN binding|wybutosine biosynthetic process|metal ion binding|4 iron, 4 sulfur cluster binding|oxidation-reduction process|tRNA-4-demethylwyosine synthase activity" TYW3 145.5151334 148.7791852 142.2510815 0.956122197 -0.064733081 0.891310964 1 6.089012017 5.724418949 127253 tRNA-yW synthesizing protein 3 homolog "GO:0005515,GO:0005737,GO:0008175,GO:0030488" protein binding|cytoplasm|tRNA methyltransferase activity|tRNA methylation TYW5 496.8403298 490.0349387 503.6457209 1.027775126 0.039524642 0.892590218 1 4.982332641 5.035029285 129450 tRNA-yW synthesizing protein 5 "GO:0000049,GO:0005506,GO:0005737,GO:0006400,GO:0016706,GO:0031591,GO:0042803,GO:0055114,GO:0102524" tRNA binding|iron ion binding|cytoplasm|tRNA modification|2-oxoglutarate-dependent dioxygenase activity|wybutosine biosynthetic process|protein homodimerization activity|oxidation-reduction process|tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity U2AF1 110.0272049 62.42483296 157.6295768 2.525110109 1.336346299 0.003576105 0.380284526 2.995951981 7.438516787 7307 U2 small nuclear RNA auxiliary factor 1 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005681,GO:0006397,GO:0006405,GO:0006406,GO:0008380,GO:0015030,GO:0016607,GO:0030628,GO:0031124,GO:0046872,GO:0071013,GO:0089701" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|spliceosomal complex|mRNA processing|RNA export from nucleus|mRNA export from nucleus|RNA splicing|Cajal body|nuclear speck|pre-mRNA 3'-splice site binding|mRNA 3'-end processing|metal ion binding|catalytic step 2 spliceosome|U2AF complex" "hsa03040,hsa05131" Spliceosome|Shigellosis U2AF1L4 57.08436936 60.34400519 53.82473354 0.891964883 -0.164941183 0.798718307 1 3.889430736 3.411182672 199746 U2 small nuclear RNA auxiliary factor 1 like 4 "GO:0000398,GO:0005654,GO:0005681,GO:0005737,GO:0006405,GO:0006406,GO:0016607,GO:0030628,GO:0031124,GO:0046872,GO:0089701" "mRNA splicing, via spliceosome|nucleoplasm|spliceosomal complex|cytoplasm|RNA export from nucleus|mRNA export from nucleus|nuclear speck|pre-mRNA 3'-splice site binding|mRNA 3'-end processing|metal ion binding|U2AF complex" "hsa03040,hsa05131" Spliceosome|Shigellosis U2AF1L5 89.14408533 107.1626299 71.12554074 0.663715894 -0.591362271 0.22581944 1 4.913292613 3.206461473 102724594 U2 small nuclear RNA auxiliary factor 1 like 5 "GO:0000398,GO:0005515,GO:0005654,GO:0005681,GO:0016607,GO:0030628,GO:0046872,GO:0089701" "mRNA splicing, via spliceosome|protein binding|nucleoplasm|spliceosomal complex|nuclear speck|pre-mRNA 3'-splice site binding|metal ion binding|U2AF complex" "hsa03040,hsa05131" Spliceosome|Shigellosis U2AF2 2360.663541 2424.164347 2297.162735 0.947610148 -0.077634447 0.74381043 1 40.21547894 37.4709002 11338 U2 small nuclear RNA auxiliary factor 2 "GO:0000243,GO:0000398,GO:0000974,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0006397,GO:0006405,GO:0006406,GO:0008187,GO:0016607,GO:0019899,GO:0030628,GO:0031124,GO:0031397,GO:0033120,GO:0048025,GO:0070742,GO:0071004,GO:0089701" "commitment complex|mRNA splicing, via spliceosome|Prp19 complex|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|mRNA processing|RNA export from nucleus|mRNA export from nucleus|poly-pyrimidine tract binding|nuclear speck|enzyme binding|pre-mRNA 3'-splice site binding|mRNA 3'-end processing|negative regulation of protein ubiquitination|positive regulation of RNA splicing|negative regulation of mRNA splicing, via spliceosome|C2H2 zinc finger domain binding|U2-type prespliceosome|U2AF complex" hsa03040 Spliceosome U2SURP 3830.75242 3912.996613 3748.508228 0.957963576 -0.061957292 0.795311613 1 30.0647045 28.31894791 23350 U2 snRNP associated SURP domain containing "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm" hsa03040 Spliceosome UACA 3102.164679 3394.870499 2809.458859 0.82755995 -0.273064268 0.248965141 1 23.16261813 18.84769696 55075 uveal autoantigen with coiled-coil domains and ankyrin repeats "GO:0003674,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0005856,GO:0008150,GO:0043280,GO:0070062,GO:0097190,GO:1901223" molecular_function|protein binding|extracellular region|nucleus|nucleoplasm|cytosol|cytoskeleton|biological_process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|extracellular exosome|apoptotic signaling pathway|negative regulation of NIK/NF-kappaB signaling UAP1 7055.553572 5695.225594 8415.881551 1.477708198 0.56336141 0.021537318 0.822216713 116.9464111 169.9208845 6675 UDP-N-acetylglucosamine pyrophosphorylase 1 "GO:0003977,GO:0005654,GO:0005829,GO:0005886,GO:0006048,GO:0030246,GO:0042802,GO:0052630" UDP-N-acetylglucosamine diphosphorylase activity|nucleoplasm|cytosol|plasma membrane|UDP-N-acetylglucosamine biosynthetic process|carbohydrate binding|identical protein binding|UDP-N-acetylgalactosamine diphosphorylase activity hsa00520 Amino sugar and nucleotide sugar metabolism UAP1L1 562.1681379 665.8648849 458.471391 0.688535169 -0.538397749 0.043155996 1 8.908494635 6.031170824 91373 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 "GO:0003977,GO:0006048" UDP-N-acetylglucosamine diphosphorylase activity|UDP-N-acetylglucosamine biosynthetic process hsa00520 Amino sugar and nucleotide sugar metabolism UBA1 12604.78338 12066.72021 13142.84654 1.089181344 0.123244177 0.631926267 1 81.19766485 86.95907518 7317 ubiquitin like modifier activating enzyme 1 "GO:0000792,GO:0003723,GO:0004839,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005765,GO:0005829,GO:0006511,GO:0006974,GO:0010008,GO:0016567,GO:0018215,GO:0030057,GO:0030867,GO:0032446,GO:0070062" heterochromatin|RNA binding|ubiquitin activating enzyme activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|lysosomal membrane|cytosol|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|endosome membrane|protein ubiquitination|protein phosphopantetheinylation|desmosome|rough endoplasmic reticulum membrane|protein modification by small protein conjugation|extracellular exosome "hsa04120,hsa05012,hsa05022" Ubiquitin mediated proteolysis|Parkinson disease|Pathways of neurodegeneration - multiple diseases UBA2 2681.153717 2561.498979 2800.808456 1.09342556 0.128855006 0.58647477 1 46.43427061 49.92281069 10054 ubiquitin like modifier activating enzyme 2 "GO:0000287,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0008134,GO:0016740,GO:0016925,GO:0018215,GO:0019948,GO:0031510,GO:0032183,GO:0032446,GO:0033235,GO:0044388,GO:0044390,GO:0046982" magnesium ion binding|protein binding|ATP binding|nucleoplasm|cytoplasm|transcription factor binding|transferase activity|protein sumoylation|protein phosphopantetheinylation|SUMO activating enzyme activity|SUMO activating enzyme complex|SUMO binding|protein modification by small protein conjugation|positive regulation of protein sumoylation|small protein activating enzyme binding|ubiquitin-like protein conjugating enzyme binding|protein heterodimerization activity hsa04120 Ubiquitin mediated proteolysis UBA3 1424.384896 1411.841639 1436.928154 1.017768647 0.025409654 0.918456947 1 35.69274913 35.71907848 9039 ubiquitin like modifier activating enzyme 3 "GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0007113,GO:0016922,GO:0018215,GO:0019781,GO:0019788,GO:0032446,GO:0032991,GO:0042802,GO:0043687,GO:0044877,GO:0045116,GO:0045892,GO:0046982,GO:0051726" "protein binding|ATP binding|nucleus|cytoplasm|cytosol|cellular protein modification process|proteolysis|endomitotic cell cycle|nuclear receptor binding|protein phosphopantetheinylation|NEDD8 activating enzyme activity|NEDD8 transferase activity|protein modification by small protein conjugation|protein-containing complex|identical protein binding|post-translational protein modification|protein-containing complex binding|protein neddylation|negative regulation of transcription, DNA-templated|protein heterodimerization activity|regulation of cell cycle" hsa04120 Ubiquitin mediated proteolysis UBA5 741.2696239 750.1384094 732.4008385 0.976354269 -0.034523372 0.897267187 1 6.944233862 6.666577717 79876 ubiquitin like modifier activating enzyme 5 "GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005789,GO:0005794,GO:0005829,GO:0008270,GO:0018215,GO:0030218,GO:0030219,GO:0032446,GO:0033146,GO:0034976,GO:0042803,GO:0043231,GO:0050905,GO:0061709,GO:0071566,GO:0071569,GO:1990592" protein binding|ATP binding|nucleus|cytoplasm|endoplasmic reticulum membrane|Golgi apparatus|cytosol|zinc ion binding|protein phosphopantetheinylation|erythrocyte differentiation|megakaryocyte differentiation|protein modification by small protein conjugation|regulation of intracellular estrogen receptor signaling pathway|response to endoplasmic reticulum stress|protein homodimerization activity|intracellular membrane-bounded organelle|neuromuscular process|reticulophagy|UFM1 activating enzyme activity|protein ufmylation|protein K69-linked ufmylation UBA52 7036.133652 6283.059437 7789.207867 1.23971577 0.310009391 0.204971798 1 84.76120687 103.3214366 7311 ubiquitin A-52 residue ribosomal protein fusion product 1 "GO:0000122,GO:0000184,GO:0000187,GO:0000209,GO:0000715,GO:0000717,GO:0002755,GO:0002756,GO:0003735,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005741,GO:0005765,GO:0005783,GO:0005789,GO:0005829,GO:0005886,GO:0006283,GO:0006294,GO:0006296,GO:0006297,GO:0006413,GO:0006464,GO:0006614,GO:0006625,GO:0007179,GO:0007249,GO:0007254,GO:0010008,GO:0016055,GO:0016197,GO:0016567,GO:0016579,GO:0019058,GO:0019068,GO:0019083,GO:0019221,GO:0019941,GO:0019985,GO:0022627,GO:0030512,GO:0030666,GO:0031145,GO:0031386,GO:0031625,GO:0031982,GO:0033683,GO:0035666,GO:0036297,GO:0042276,GO:0042769,GO:0043065,GO:0043066,GO:0043488,GO:0043657,GO:0044267,GO:0045944,GO:0051092,GO:0051403,GO:0055085,GO:0061024,GO:0061418,GO:0070062,GO:0070423,GO:0070498,GO:0070911,GO:0070987,GO:0075733" "negative regulation of transcription by RNA polymerase II|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|activation of MAPK activity|protein polyubiquitination|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|structural constituent of ribosome|protein binding|extracellular space|nucleus|nucleoplasm|cytoplasm|mitochondrial outer membrane|lysosomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|plasma membrane|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|translational initiation|cellular protein modification process|SRP-dependent cotranslational protein targeting to membrane|protein targeting to peroxisome|transforming growth factor beta receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|JNK cascade|endosome membrane|Wnt signaling pathway|endosomal transport|protein ubiquitination|protein deubiquitination|viral life cycle|virion assembly|viral transcription|cytokine-mediated signaling pathway|modification-dependent protein catabolic process|translesion synthesis|cytosolic small ribosomal subunit|negative regulation of transforming growth factor beta receptor signaling pathway|endocytic vesicle membrane|anaphase-promoting complex-dependent catabolic process|protein tag|ubiquitin protein ligase binding|vesicle|nucleotide-excision repair, DNA incision|TRIF-dependent toll-like receptor signaling pathway|interstrand cross-link repair|error-prone translesion synthesis|DNA damage response, detection of DNA damage|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of mRNA stability|host cell|cellular protein metabolic process|positive regulation of transcription by RNA polymerase II|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|transmembrane transport|membrane organization|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|global genome nucleotide-excision repair|error-free translesion synthesis|intracellular transport of virus" "hsa03010,hsa04120,hsa04137,hsa05012,hsa05022,hsa05131,hsa05167,hsa05171" Ribosome|Ubiquitin mediated proteolysis|Mitophagy - animal|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Shigellosis|Kaposi sarcoma-associated herpesvirus infection|Coronavirus disease - COVID-19 UBA6 3822.268021 3500.992715 4143.543326 1.183533833 0.243100948 0.306825694 1 19.58506778 22.79171128 55236 ubiquitin like modifier activating enzyme 6 "GO:0004839,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006511,GO:0006974,GO:0007612,GO:0007626,GO:0016567,GO:0018215,GO:0019780,GO:0021764,GO:0021766,GO:0032446,GO:0060996" ubiquitin activating enzyme activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|learning|locomotory behavior|protein ubiquitination|protein phosphopantetheinylation|FAT10 activating enzyme activity|amygdala development|hippocampus development|protein modification by small protein conjugation|dendritic spine development hsa04120 Ubiquitin mediated proteolysis UBA7 219.860681 208.0827765 231.6385854 1.11320403 0.154718037 0.667786959 1 3.195682113 3.497917162 7318 ubiquitin like modifier activating enzyme 7 "GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006464,GO:0006974,GO:0016567,GO:0018215,GO:0019782,GO:0019941,GO:0032020,GO:0032446,GO:0032480" ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|cellular protein modification process|cellular response to DNA damage stimulus|protein ubiquitination|protein phosphopantetheinylation|ISG15 activating enzyme activity|modification-dependent protein catabolic process|ISG15-protein conjugation|protein modification by small protein conjugation|negative regulation of type I interferon production "hsa04120,hsa05012,hsa05022" Ubiquitin mediated proteolysis|Parkinson disease|Pathways of neurodegeneration - multiple diseases UBAC1 860.7549029 795.9166202 925.5931856 1.162927324 0.21776094 0.383816623 1 22.83688559 26.11323214 10422 UBA domain containing 1 "GO:0005515,GO:0005794,GO:0005829,GO:0005886,GO:0016567,GO:0070062" protein binding|Golgi apparatus|cytosol|plasma membrane|protein ubiquitination|extracellular exosome UBAC2 1171.305199 1151.738168 1190.872229 1.033978262 0.048205855 0.845720812 1 9.328600581 9.484164662 337867 UBA domain containing 2 "GO:0005515,GO:0005783,GO:0005789,GO:0016021,GO:0016055,GO:0070972,GO:0090090,GO:1904153" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|Wnt signaling pathway|protein localization to endoplasmic reticulum|negative regulation of canonical Wnt signaling pathway|negative regulation of retrograde protein transport, ER to cytosol" UBALD1 216.4865743 233.0527097 199.9204388 0.857833574 -0.221230314 0.536359807 1 9.05210683 7.635261027 124402 UBA like domain containing 1 GO:0005515 protein binding UBALD2 1068.352685 1123.646993 1013.058378 0.901580642 -0.149471555 0.542400749 1 41.47093697 36.7637331 283991 UBA like domain containing 2 UBAP1 1645.048218 1615.76276 1674.333675 1.0362497 0.051371684 0.831173041 1 22.81224573 23.24361308 51271 ubiquitin associated protein 1 "GO:0000813,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0010008,GO:0015031,GO:0016197,GO:0019058,GO:0043130,GO:0043162,GO:0043231,GO:0043657,GO:0075733" ESCRT I complex|protein binding|cytoplasm|cytosol|plasma membrane|endosome membrane|protein transport|endosomal transport|viral life cycle|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|intracellular membrane-bounded organelle|host cell|intracellular transport of virus UBAP1L 21.65557714 26.01034707 17.30080721 0.665150956 -0.588246298 0.495969909 1 0.0807096 0.052785738 390595 ubiquitin associated protein 1 like "GO:0000813,GO:0043130,GO:0043162" ESCRT I complex|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway UBAP2 1507.255702 1682.349248 1332.162155 0.791846376 -0.336707531 0.15813425 1 18.95374443 14.75730768 55833 ubiquitin associated protein 2 "GO:0000932,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0010629,GO:0043065,GO:0045296,GO:0045893,GO:0045926,GO:0046426" "P-body|RNA binding|protein binding|nucleus|cytoplasm|negative regulation of gene expression|positive regulation of apoptotic process|cadherin binding|positive regulation of transcription, DNA-templated|negative regulation of growth|negative regulation of receptor signaling pathway via JAK-STAT" UBAP2L 3151.94603 3490.588576 2813.303483 0.805968226 -0.311205131 0.188999108 1 34.34481875 27.2176314 9898 ubiquitin associated protein 2 like "GO:0003723,GO:0005515,GO:0005634,GO:0005671,GO:0005737,GO:0007339,GO:0010494,GO:0031519,GO:0034063,GO:0061484" RNA binding|protein binding|nucleus|Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|binding of sperm to zona pellucida|cytoplasmic stress granule|PcG protein complex|stress granule assembly|hematopoietic stem cell homeostasis UBASH3B 2666.781652 2449.13428 2884.429024 1.177734127 0.236013889 0.318371107 1 13.5643208 15.70784079 84959 ubiquitin associated and SH3 domain containing B "GO:0004725,GO:0005515,GO:0005634,GO:0005737,GO:0006469,GO:0009968,GO:0031625,GO:0035335,GO:0038063,GO:0042802,GO:0043393,GO:0045670,GO:0045671,GO:0045779,GO:0051219,GO:0051279,GO:0070527,GO:0090331" protein tyrosine phosphatase activity|protein binding|nucleus|cytoplasm|negative regulation of protein kinase activity|negative regulation of signal transduction|ubiquitin protein ligase binding|peptidyl-tyrosine dephosphorylation|collagen-activated tyrosine kinase receptor signaling pathway|identical protein binding|regulation of protein binding|regulation of osteoclast differentiation|negative regulation of osteoclast differentiation|negative regulation of bone resorption|phosphoprotein binding|regulation of release of sequestered calcium ion into cytosol|platelet aggregation|negative regulation of platelet aggregation UBB 15356.48464 15168.194 15544.77528 1.024827035 0.035380439 0.893332275 1 533.6180854 537.7151743 7314 ubiquitin B "GO:0000122,GO:0000187,GO:0000209,GO:0000715,GO:0000717,GO:0002755,GO:0002756,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005789,GO:0005829,GO:0005886,GO:0006283,GO:0006294,GO:0006296,GO:0006297,GO:0006625,GO:0007141,GO:0007144,GO:0007179,GO:0007249,GO:0007254,GO:0008585,GO:0010008,GO:0016055,GO:0016197,GO:0016567,GO:0016579,GO:0019058,GO:0019068,GO:0019221,GO:0019941,GO:0019985,GO:0021888,GO:0030512,GO:0030666,GO:0031145,GO:0031386,GO:0031398,GO:0031625,GO:0031982,GO:0033683,GO:0035666,GO:0036297,GO:0042276,GO:0042769,GO:0043005,GO:0043025,GO:0043065,GO:0043066,GO:0043488,GO:0043657,GO:0044267,GO:0045944,GO:0047497,GO:0048812,GO:0051092,GO:0051403,GO:0051881,GO:0055085,GO:0060613,GO:0061024,GO:0061136,GO:0061418,GO:0070062,GO:0070423,GO:0070498,GO:0070911,GO:0070987,GO:0072520,GO:0075733,GO:0097009,GO:1901214,GO:1902255,GO:1902527" "negative regulation of transcription by RNA polymerase II|activation of MAPK activity|protein polyubiquitination|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|protein binding|extracellular space|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum membrane|cytosol|plasma membrane|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|protein targeting to peroxisome|male meiosis I|female meiosis I|transforming growth factor beta receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|JNK cascade|female gonad development|endosome membrane|Wnt signaling pathway|endosomal transport|protein ubiquitination|protein deubiquitination|viral life cycle|virion assembly|cytokine-mediated signaling pathway|modification-dependent protein catabolic process|translesion synthesis|hypothalamus gonadotrophin-releasing hormone neuron development|negative regulation of transforming growth factor beta receptor signaling pathway|endocytic vesicle membrane|anaphase-promoting complex-dependent catabolic process|protein tag|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|vesicle|nucleotide-excision repair, DNA incision|TRIF-dependent toll-like receptor signaling pathway|interstrand cross-link repair|error-prone translesion synthesis|DNA damage response, detection of DNA damage|neuron projection|neuronal cell body|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of mRNA stability|host cell|cellular protein metabolic process|positive regulation of transcription by RNA polymerase II|mitochondrion transport along microtubule|neuron projection morphogenesis|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|regulation of mitochondrial membrane potential|transmembrane transport|fat pad development|membrane organization|regulation of proteasomal protein catabolic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|global genome nucleotide-excision repair|error-free translesion synthesis|seminiferous tubule development|intracellular transport of virus|energy homeostasis|regulation of neuron death|positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator|positive regulation of protein monoubiquitination" "hsa04120,hsa04137,hsa05012,hsa05022,hsa05131,hsa05167" Ubiquitin mediated proteolysis|Mitophagy - animal|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Shigellosis|Kaposi sarcoma-associated herpesvirus infection UBC 24207.47223 23361.45332 25053.49115 1.07242862 0.100881626 0.72017664 1 568.5170211 599.4915223 7316 ubiquitin C "GO:0000122,GO:0000187,GO:0000209,GO:0000715,GO:0000717,GO:0002020,GO:0002755,GO:0002756,GO:0003723,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005741,GO:0005789,GO:0005829,GO:0005886,GO:0006283,GO:0006294,GO:0006296,GO:0006297,GO:0006625,GO:0007179,GO:0007249,GO:0007254,GO:0010008,GO:0016055,GO:0016197,GO:0016567,GO:0016579,GO:0019058,GO:0019068,GO:0019221,GO:0019941,GO:0019985,GO:0030512,GO:0030666,GO:0031145,GO:0031386,GO:0031625,GO:0031982,GO:0033683,GO:0035666,GO:0036297,GO:0042276,GO:0042769,GO:0043065,GO:0043066,GO:0043488,GO:0043657,GO:0044267,GO:0045944,GO:0051092,GO:0051403,GO:0055085,GO:0061024,GO:0061418,GO:0070062,GO:0070423,GO:0070498,GO:0070911,GO:0070987,GO:0075733" "negative regulation of transcription by RNA polymerase II|activation of MAPK activity|protein polyubiquitination|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|protease binding|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|RNA binding|protein binding|extracellular space|nucleus|nucleoplasm|cytoplasm|mitochondrial outer membrane|endoplasmic reticulum membrane|cytosol|plasma membrane|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|protein targeting to peroxisome|transforming growth factor beta receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|JNK cascade|endosome membrane|Wnt signaling pathway|endosomal transport|protein ubiquitination|protein deubiquitination|viral life cycle|virion assembly|cytokine-mediated signaling pathway|modification-dependent protein catabolic process|translesion synthesis|negative regulation of transforming growth factor beta receptor signaling pathway|endocytic vesicle membrane|anaphase-promoting complex-dependent catabolic process|protein tag|ubiquitin protein ligase binding|vesicle|nucleotide-excision repair, DNA incision|TRIF-dependent toll-like receptor signaling pathway|interstrand cross-link repair|error-prone translesion synthesis|DNA damage response, detection of DNA damage|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of mRNA stability|host cell|cellular protein metabolic process|positive regulation of transcription by RNA polymerase II|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|transmembrane transport|membrane organization|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|global genome nucleotide-excision repair|error-free translesion synthesis|intracellular transport of virus" "hsa03320,hsa04120,hsa04137,hsa05012,hsa05022,hsa05131,hsa05167" PPAR signaling pathway|Ubiquitin mediated proteolysis|Mitophagy - animal|Parkinson disease|Pathways of neurodegeneration - multiple diseases|Shigellosis|Kaposi sarcoma-associated herpesvirus infection UBD 1.922311912 0 3.844623824 Inf Inf 0.288176591 1 0 0.225667885 10537 ubiquitin D "GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006508,GO:0006511,GO:0016235,GO:0016567,GO:0032446,GO:0034341,GO:0034612,GO:0043011,GO:0043065,GO:0043123,GO:0043687,GO:0070628,GO:0070842,GO:1901990" fibrillar center|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteolysis|ubiquitin-dependent protein catabolic process|aggresome|protein ubiquitination|protein modification by small protein conjugation|response to interferon-gamma|response to tumor necrosis factor|myeloid dendritic cell differentiation|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|post-translational protein modification|proteasome binding|aggresome assembly|regulation of mitotic cell cycle phase transition UBE2A 3003.130287 2687.389059 3318.871516 1.234979917 0.304487581 0.198464156 1 80.75507593 98.06203545 7319 ubiquitin conjugating enzyme E2 A "GO:0000209,GO:0000785,GO:0001741,GO:0001835,GO:0004842,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006281,GO:0006301,GO:0006511,GO:0008284,GO:0009411,GO:0016567,GO:0016574,GO:0031625,GO:0033503,GO:0033522,GO:0043161,GO:0051865,GO:0060135,GO:0061631,GO:0070936,GO:0070979" protein polyubiquitination|chromatin|XY body|blastocyst hatching|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleoplasm|cytosol|DNA repair|postreplication repair|ubiquitin-dependent protein catabolic process|positive regulation of cell population proliferation|response to UV|protein ubiquitination|histone ubiquitination|ubiquitin protein ligase binding|HULC complex|histone H2A ubiquitination|proteasome-mediated ubiquitin-dependent protein catabolic process|protein autoubiquitination|maternal process involved in female pregnancy|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination|protein K11-linked ubiquitination hsa04120 Ubiquitin mediated proteolysis UBE2B 998.0461048 880.1901447 1115.902065 1.267796591 0.342323294 0.163911914 1 20.96123619 26.12989411 7320 ubiquitin conjugating enzyme E2 B "GO:0000209,GO:0000785,GO:0001701,GO:0001741,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005657,GO:0005737,GO:0005886,GO:0006281,GO:0006301,GO:0006511,GO:0006513,GO:0006974,GO:0007283,GO:0007288,GO:0009411,GO:0010845,GO:0016567,GO:0016574,GO:0031625,GO:0033128,GO:0033503,GO:0033522,GO:0042493,GO:0042769,GO:0043066,GO:0043161,GO:0043951,GO:0045141,GO:0050821,GO:0051026,GO:0051865,GO:0061631,GO:0070076,GO:0070193,GO:0070534,GO:0070829,GO:0070936,GO:0070979,GO:0090263" "protein polyubiquitination|chromatin|in utero embryonic development|XY body|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|replication fork|cytoplasm|plasma membrane|DNA repair|postreplication repair|ubiquitin-dependent protein catabolic process|protein monoubiquitination|cellular response to DNA damage stimulus|spermatogenesis|sperm axoneme assembly|response to UV|positive regulation of reciprocal meiotic recombination|protein ubiquitination|histone ubiquitination|ubiquitin protein ligase binding|negative regulation of histone phosphorylation|HULC complex|histone H2A ubiquitination|response to drug|DNA damage response, detection of DNA damage|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of cAMP-mediated signaling|meiotic telomere clustering|protein stabilization|chiasma assembly|protein autoubiquitination|ubiquitin conjugating enzyme activity|histone lysine demethylation|synaptonemal complex organization|protein K63-linked ubiquitination|heterochromatin maintenance|protein K48-linked ubiquitination|protein K11-linked ubiquitination|positive regulation of canonical Wnt signaling pathway" hsa04120 Ubiquitin mediated proteolysis UBE2C 4339.607814 4302.111405 4377.104224 1.017431631 0.024931852 0.917793172 1 187.5782506 187.6544619 11065 ubiquitin conjugating enzyme E2 C "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005680,GO:0005829,GO:0005886,GO:0006511,GO:0010458,GO:0010994,GO:0016567,GO:0030071,GO:0031145,GO:0031536,GO:0044389,GO:0051301,GO:0061631,GO:0070936,GO:0070979,GO:1901990,GO:1904668" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|anaphase-promoting complex|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|exit from mitosis|free ubiquitin chain polymerization|protein ubiquitination|regulation of mitotic metaphase/anaphase transition|anaphase-promoting complex-dependent catabolic process|positive regulation of exit from mitosis|ubiquitin-like protein ligase binding|cell division|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination|protein K11-linked ubiquitination|regulation of mitotic cell cycle phase transition|positive regulation of ubiquitin protein ligase activity hsa04120 Ubiquitin mediated proteolysis UBE2D1 801.7727594 774.0679287 829.47759 1.071582427 0.099742828 0.695167616 1 15.74936435 16.59433265 7321 ubiquitin conjugating enzyme E2 D1 "GO:0000122,GO:0000151,GO:0000209,GO:0002756,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0006625,GO:0016567,GO:0016579,GO:0030509,GO:0031145,GO:0031398,GO:0031625,GO:0032991,GO:0035666,GO:0061630,GO:0061631,GO:0070936,GO:1901990,GO:1902916" negative regulation of transcription by RNA polymerase II|ubiquitin ligase complex|protein polyubiquitination|MyD88-independent toll-like receptor signaling pathway|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein targeting to peroxisome|protein ubiquitination|protein deubiquitination|BMP signaling pathway|anaphase-promoting complex-dependent catabolic process|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|protein-containing complex|TRIF-dependent toll-like receptor signaling pathway|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination|regulation of mitotic cell cycle phase transition|positive regulation of protein polyubiquitination "hsa04120,hsa04141,hsa05131" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Shigellosis UBE2D2 2440.133129 2289.950956 2590.315301 1.131166279 0.177811018 0.452296788 1 39.75617233 44.21831539 7322 ubiquitin conjugating enzyme E2 D2 "GO:0000151,GO:0000209,GO:0002756,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006464,GO:0006511,GO:0006625,GO:0016567,GO:0032991,GO:0035666,GO:0051865,GO:0061630,GO:0061631,GO:0070062,GO:0070936" ubiquitin ligase complex|protein polyubiquitination|MyD88-independent toll-like receptor signaling pathway|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|cellular protein modification process|ubiquitin-dependent protein catabolic process|protein targeting to peroxisome|protein ubiquitination|protein-containing complex|TRIF-dependent toll-like receptor signaling pathway|protein autoubiquitination|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|extracellular exosome|protein K48-linked ubiquitination "hsa04120,hsa04141,hsa05131" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Shigellosis UBE2D3 5050.360064 4755.731858 5344.988271 1.123904465 0.168519408 0.48300211 1 48.7149076 53.83471998 7323 ubiquitin conjugating enzyme E2 D3 "GO:0000122,GO:0000209,GO:0002756,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006281,GO:0006464,GO:0006513,GO:0006625,GO:0006915,GO:0010008,GO:0016567,GO:0030509,GO:0035666,GO:0043161,GO:0051865,GO:0061630,GO:0061631,GO:0070062,GO:0070936,GO:0070979,GO:0071276,GO:0071288,GO:1903955" negative regulation of transcription by RNA polymerase II|protein polyubiquitination|MyD88-independent toll-like receptor signaling pathway|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|DNA repair|cellular protein modification process|protein monoubiquitination|protein targeting to peroxisome|apoptotic process|endosome membrane|protein ubiquitination|BMP signaling pathway|TRIF-dependent toll-like receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|protein autoubiquitination|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|extracellular exosome|protein K48-linked ubiquitination|protein K11-linked ubiquitination|cellular response to cadmium ion|cellular response to mercury ion|positive regulation of protein targeting to mitochondrion "hsa04120,hsa04141,hsa05131" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Shigellosis UBE2D4 126.9311081 152.9408407 100.9213754 0.65987198 -0.599741937 0.16372416 1 2.066895816 1.341063838 51619 ubiquitin conjugating enzyme E2 D4 (putative) "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0006511,GO:0016567,GO:0031625,GO:0035519,GO:0044314,GO:0061631,GO:0070534,GO:0070936,GO:0070979,GO:0085020" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|ubiquitin-dependent protein catabolic process|protein ubiquitination|ubiquitin protein ligase binding|protein K29-linked ubiquitination|protein K27-linked ubiquitination|ubiquitin conjugating enzyme activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination|protein K6-linked ubiquitination "hsa04120,hsa04141,hsa05131" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Shigellosis UBE2E1 2244.2919 2005.917966 2482.665834 1.237670671 0.307627482 0.193213157 1 55.72730615 67.8178985 7324 ubiquitin conjugating enzyme E2 E1 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0010390,GO:0016567,GO:0018215,GO:0031145,GO:0032020,GO:0033523,GO:0042296,GO:0061631,GO:0070936,GO:1901990" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|histone monoubiquitination|protein ubiquitination|protein phosphopantetheinylation|anaphase-promoting complex-dependent catabolic process|ISG15-protein conjugation|histone H2B ubiquitination|ISG15 transferase activity|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination|regulation of mitotic cell cycle phase transition hsa04120 Ubiquitin mediated proteolysis UBE2E2 675.0001671 625.2887435 724.7115908 1.159003098 0.212884423 0.410178051 1 1.542289181 1.757606247 7325 ubiquitin conjugating enzyme E2 E2 "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0006974,GO:0018215,GO:0032020,GO:0042296,GO:0061631,GO:0070534,GO:0070936,GO:0070979,GO:1900087" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|cellular response to DNA damage stimulus|protein phosphopantetheinylation|ISG15-protein conjugation|ISG15 transferase activity|ubiquitin conjugating enzyme activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination|positive regulation of G1/S transition of mitotic cell cycle hsa04120 Ubiquitin mediated proteolysis UBE2E3 1411.474687 1249.537073 1573.4123 1.259196173 0.332503061 0.164943727 1 8.832516164 10.93576111 10477 ubiquitin conjugating enzyme E2 E3 "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0016567,GO:0040008,GO:0061631,GO:0070534,GO:0070936,GO:0070979" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|protein ubiquitination|regulation of growth|ubiquitin conjugating enzyme activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination hsa04120 Ubiquitin mediated proteolysis UBE2F 862.1022877 831.2906922 892.9138831 1.074129533 0.103167984 0.68230433 1 19.63898026 20.74181564 140739 ubiquitin conjugating enzyme E2 F (putative) "GO:0000209,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0018215,GO:0019788,GO:0043687,GO:0045116,GO:0061631,GO:0061654" protein polyubiquitination|protein binding|ATP binding|nucleus|cytosol|protein phosphopantetheinylation|NEDD8 transferase activity|post-translational protein modification|protein neddylation|ubiquitin conjugating enzyme activity|NEDD8 conjugating enzyme activity hsa04120 Ubiquitin mediated proteolysis UBE2G1 1742.059574 1778.067325 1706.051822 0.959497876 -0.059648482 0.803521814 1 22.77230267 21.48434628 7326 ubiquitin conjugating enzyme E2 G1 "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005829,GO:0006511,GO:0016567,GO:0031625,GO:0043161,GO:0044257,GO:0061631,GO:0070062,GO:0070534,GO:0070936" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|ubiquitin protein ligase binding|proteasome-mediated ubiquitin-dependent protein catabolic process|cellular protein catabolic process|ubiquitin conjugating enzyme activity|extracellular exosome|protein K63-linked ubiquitination|protein K48-linked ubiquitination "hsa04120,hsa04141,hsa05012,hsa05022" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Parkinson disease|Pathways of neurodegeneration - multiple diseases UBE2G2 1737.585917 1748.935737 1726.236097 0.987020884 -0.018847484 0.939256534 1 26.24050769 25.46652886 7327 ubiquitin conjugating enzyme E2 G2 "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005783,GO:0005811,GO:0005829,GO:0006511,GO:0016567,GO:0030433,GO:0035458,GO:0042802,GO:0044257,GO:0061631,GO:0070936,GO:1904153" "protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|endoplasmic reticulum|lipid droplet|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|ubiquitin-dependent ERAD pathway|cellular response to interferon-beta|identical protein binding|cellular protein catabolic process|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination|negative regulation of retrograde protein transport, ER to cytosol" "hsa04120,hsa04141,hsa05012,hsa05022" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Parkinson disease|Pathways of neurodegeneration - multiple diseases UBE2H 5216.70617 5287.383352 5146.028988 0.973265724 -0.039094346 0.87156066 1 54.6644579 52.31276234 7328 ubiquitin conjugating enzyme E2 H "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0006511,GO:0016567,GO:0043161,GO:0061631,GO:0070936,GO:0070979" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination|protein K11-linked ubiquitination hsa04120 Ubiquitin mediated proteolysis UBE2I 2637.074522 2527.165321 2746.983722 1.086982201 0.120328317 0.611557987 1 34.63537967 37.01805224 7329 ubiquitin conjugating enzyme E2 I "GO:0000122,GO:0000795,GO:0001221,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005829,GO:0006464,GO:0006511,GO:0007049,GO:0007059,GO:0008134,GO:0016032,GO:0016605,GO:0016925,GO:0019789,GO:0019899,GO:0044388,GO:0045892,GO:0051301,GO:0061656,GO:0071535,GO:1903755,GO:1990234,GO:1990356" "negative regulation of transcription by RNA polymerase II|synaptonemal complex|transcription coregulator binding|RNA binding|protein binding|ATP binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|cytosol|cellular protein modification process|ubiquitin-dependent protein catabolic process|cell cycle|chromosome segregation|transcription factor binding|viral process|PML body|protein sumoylation|SUMO transferase activity|enzyme binding|small protein activating enzyme binding|negative regulation of transcription, DNA-templated|cell division|SUMO conjugating enzyme activity|RING-like zinc finger domain binding|positive regulation of SUMO transferase activity|transferase complex|sumoylated E2 ligase complex" "hsa03013,hsa04064,hsa04120,hsa05206" RNA transport|NF-kappa B signaling pathway|Ubiquitin mediated proteolysis|MicroRNAs in cancer other UBE2J1 1587.681415 1560.620824 1614.742006 1.034679264 0.049183622 0.838686717 1 20.00179277 20.34913006 51465 ubiquitin conjugating enzyme E2 J1 "GO:0000209,GO:0005515,GO:0005524,GO:0005634,GO:0005789,GO:0007286,GO:0016021,GO:0018279,GO:0030433,GO:0031625,GO:0032680,GO:0061631,GO:1904153" "protein polyubiquitination|protein binding|ATP binding|nucleus|endoplasmic reticulum membrane|spermatid development|integral component of membrane|protein N-linked glycosylation via asparagine|ubiquitin-dependent ERAD pathway|ubiquitin protein ligase binding|regulation of tumor necrosis factor production|ubiquitin conjugating enzyme activity|negative regulation of retrograde protein transport, ER to cytosol" "hsa04120,hsa04141,hsa05012,hsa05022" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Parkinson disease|Pathways of neurodegeneration - multiple diseases UBE2J2 1193.020527 1128.849063 1257.19199 1.113693612 0.155352388 0.522668153 1 13.90046141 15.22180393 118424 ubiquitin conjugating enzyme E2 J2 "GO:0000151,GO:0000209,GO:0005515,GO:0005524,GO:0005634,GO:0005783,GO:0005789,GO:0006986,GO:0016021,GO:0016567,GO:0030433,GO:0031625,GO:0061631,GO:1903955" ubiquitin ligase complex|protein polyubiquitination|protein binding|ATP binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|response to unfolded protein|integral component of membrane|protein ubiquitination|ubiquitin-dependent ERAD pathway|ubiquitin protein ligase binding|ubiquitin conjugating enzyme activity|positive regulation of protein targeting to mitochondrion "hsa04120,hsa04141,hsa05012,hsa05022" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Parkinson disease|Pathways of neurodegeneration - multiple diseases UBE2K 2463.260008 2341.97165 2584.548366 1.10357799 0.142188589 0.548111132 1 24.67654938 26.7767978 3093 ubiquitin conjugating enzyme E2 K "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0006511,GO:0010800,GO:0010994,GO:0016567,GO:0031625,GO:0032433,GO:0032434,GO:0034450,GO:0035458,GO:0043161,GO:0060340,GO:0061631,GO:0070059,GO:0070936,GO:1903265" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|cytosol|ubiquitin-dependent protein catabolic process|positive regulation of peptidyl-threonine phosphorylation|free ubiquitin chain polymerization|protein ubiquitination|ubiquitin protein ligase binding|filopodium tip|regulation of proteasomal ubiquitin-dependent protein catabolic process|ubiquitin-ubiquitin ligase activity|cellular response to interferon-beta|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of type I interferon-mediated signaling pathway|ubiquitin conjugating enzyme activity|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|protein K48-linked ubiquitination|positive regulation of tumor necrosis factor-mediated signaling pathway hsa04120 Ubiquitin mediated proteolysis UBE2L3 3189.375048 2933.967149 3444.782946 1.17410413 0.231560365 0.328544067 1 47.56392295 54.91050794 7332 ubiquitin conjugating enzyme E2 L3 "GO:0000151,GO:0000209,GO:0003713,GO:0003723,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006464,GO:0006511,GO:0008283,GO:0016567,GO:0019899,GO:0031398,GO:0031625,GO:0044770,GO:0045893,GO:0051443,GO:0061631,GO:0070979,GO:0071383,GO:0071385,GO:0097027,GO:1903955" "ubiquitin ligase complex|protein polyubiquitination|transcription coactivator activity|RNA binding|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|cellular protein modification process|ubiquitin-dependent protein catabolic process|cell population proliferation|protein ubiquitination|enzyme binding|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|cell cycle phase transition|positive regulation of transcription, DNA-templated|positive regulation of ubiquitin-protein transferase activity|ubiquitin conjugating enzyme activity|protein K11-linked ubiquitination|cellular response to steroid hormone stimulus|cellular response to glucocorticoid stimulus|ubiquitin-protein transferase activator activity|positive regulation of protein targeting to mitochondrion" "hsa04120,hsa05012,hsa05022" Ubiquitin mediated proteolysis|Parkinson disease|Pathways of neurodegeneration - multiple diseases UBE2L6 1478.704685 1475.306886 1482.102484 1.004606227 0.006630123 0.981045004 1 60.28668988 59.55092112 9246 ubiquitin conjugating enzyme E2 L6 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006464,GO:0006511,GO:0018215,GO:0019985,GO:0031625,GO:0032020,GO:0032480,GO:0042296,GO:0043130,GO:0044267,GO:0061631" ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytosol|cellular protein modification process|ubiquitin-dependent protein catabolic process|protein phosphopantetheinylation|translesion synthesis|ubiquitin protein ligase binding|ISG15-protein conjugation|negative regulation of type I interferon production|ISG15 transferase activity|ubiquitin binding|cellular protein metabolic process|ubiquitin conjugating enzyme activity "hsa04120,hsa05012,hsa05022" Ubiquitin mediated proteolysis|Parkinson disease|Pathways of neurodegeneration - multiple diseases UBE2M 1055.170103 941.5745638 1168.765642 1.241288462 0.311838422 0.202617575 1 43.35643135 52.91726936 9040 ubiquitin conjugating enzyme E2 M "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006464,GO:0018215,GO:0019788,GO:0043525,GO:0043687,GO:0045116,GO:0061631" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|cellular protein modification process|protein phosphopantetheinylation|NEDD8 transferase activity|positive regulation of neuron apoptotic process|post-translational protein modification|protein neddylation|ubiquitin conjugating enzyme activity hsa04120 Ubiquitin mediated proteolysis UBE2N 2268.73218 1978.867205 2558.597155 1.292960512 0.370678215 0.116959486 1 21.65439937 27.52976995 7334 ubiquitin conjugating enzyme E2 N "GO:0000151,GO:0000187,GO:0000209,GO:0000724,GO:0000729,GO:0001650,GO:0003723,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006282,GO:0006301,GO:0006303,GO:0006511,GO:0007254,GO:0016567,GO:0016574,GO:0031058,GO:0031372,GO:0031625,GO:0032991,GO:0033182,GO:0035370,GO:0043123,GO:0043130,GO:0045739,GO:0050852,GO:0051092,GO:0051443,GO:0061631,GO:0070062,GO:0070423,GO:0070498,GO:0070534" ubiquitin ligase complex|activation of MAPK activity|protein polyubiquitination|double-strand break repair via homologous recombination|DNA double-strand break processing|fibrillar center|RNA binding|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of DNA repair|postreplication repair|double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process|JNK cascade|protein ubiquitination|histone ubiquitination|positive regulation of histone modification|UBC13-MMS2 complex|ubiquitin protein ligase binding|protein-containing complex|regulation of histone ubiquitination|UBC13-UEV1A complex|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|positive regulation of DNA repair|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein transferase activity|ubiquitin conjugating enzyme activity|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|protein K63-linked ubiquitination "hsa04120,hsa05131" Ubiquitin mediated proteolysis|Shigellosis UBE2O 1089.071644 1188.152654 989.9906347 0.833218384 -0.263233423 0.280920232 1 11.47475994 9.400990867 63893 ubiquitin conjugating enzyme E2 O "GO:0003723,GO:0004842,GO:0004869,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006513,GO:0010951,GO:0016604,GO:0030513,GO:0042147,GO:0043066,GO:0061630,GO:0061631,GO:0070534" "RNA binding|ubiquitin-protein transferase activity|cysteine-type endopeptidase inhibitor activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein monoubiquitination|negative regulation of endopeptidase activity|nuclear body|positive regulation of BMP signaling pathway|retrograde transport, endosome to Golgi|negative regulation of apoptotic process|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|protein K63-linked ubiquitination" hsa04120 Ubiquitin mediated proteolysis UBE2Q1 1543.052444 1499.236405 1586.868483 1.058451141 0.081954675 0.732901753 1 24.70252901 25.70889508 55585 ubiquitin conjugating enzyme E2 Q1 "GO:0000209,GO:0001967,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0007566,GO:0007617,GO:0009566,GO:0030175,GO:0061458,GO:0061631,GO:0070459" protein polyubiquitination|suckling behavior|protein binding|ATP binding|nucleus|cytosol|embryo implantation|mating behavior|fertilization|filopodium|reproductive system development|ubiquitin conjugating enzyme activity|prolactin secretion hsa04120 Ubiquitin mediated proteolysis UBE2Q2 685.0029859 648.1778489 721.828123 1.113626645 0.155265635 0.548477805 1 5.133114779 5.62071762 92912 ubiquitin conjugating enzyme E2 Q2 "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0016567,GO:0061631,GO:0070936" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|cytosol|protein ubiquitination|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination hsa04120 Ubiquitin mediated proteolysis UBE2R2 3396.457654 3248.172142 3544.743166 1.091303974 0.126053009 0.595636287 1 38.71989665 41.54809392 54926 ubiquitin conjugating enzyme E2 R2 "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005829,GO:0006511,GO:0006513,GO:0016567,GO:0061631,GO:0070936" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|cytosol|ubiquitin-dependent protein catabolic process|protein monoubiquitination|protein ubiquitination|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination hsa04120 Ubiquitin mediated proteolysis UBE2S 3025.419314 2830.966175 3219.872453 1.137375812 0.185709029 0.433074333 1 44.50175601 49.76824371 27338 ubiquitin conjugating enzyme E2 S "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005680,GO:0005829,GO:0006464,GO:0006511,GO:0010458,GO:0010994,GO:0010997,GO:0016567,GO:0031145,GO:0035519,GO:0044314,GO:0051301,GO:0061631,GO:0070534,GO:0070979,GO:0085020,GO:1904668" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|anaphase-promoting complex|cytosol|cellular protein modification process|ubiquitin-dependent protein catabolic process|exit from mitosis|free ubiquitin chain polymerization|anaphase-promoting complex binding|protein ubiquitination|anaphase-promoting complex-dependent catabolic process|protein K29-linked ubiquitination|protein K27-linked ubiquitination|cell division|ubiquitin conjugating enzyme activity|protein K63-linked ubiquitination|protein K11-linked ubiquitination|protein K6-linked ubiquitination|positive regulation of ubiquitin protein ligase activity hsa04120 Ubiquitin mediated proteolysis UBE2T 1387.108634 1291.153628 1483.06364 1.148634529 0.199919837 0.404811555 1 78.12527903 88.23575936 29089 ubiquitin conjugating enzyme E2 T "GO:0000209,GO:0003682,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006281,GO:0006513,GO:0006974,GO:0016567,GO:0031625,GO:0035519,GO:0036297,GO:0044314,GO:0051865,GO:0061631,GO:0070534,GO:0070936,GO:0070979,GO:0085020" protein polyubiquitination|chromatin binding|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|DNA repair|protein monoubiquitination|cellular response to DNA damage stimulus|protein ubiquitination|ubiquitin protein ligase binding|protein K29-linked ubiquitination|interstrand cross-link repair|protein K27-linked ubiquitination|protein autoubiquitination|ubiquitin conjugating enzyme activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination|protein K6-linked ubiquitination hsa03460 Fanconi anemia pathway UBE2U 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.035336218 0 148581 ubiquitin conjugating enzyme E2 U "GO:0000209,GO:0005515,GO:0005524,GO:0006281,GO:0016574,GO:0033503,GO:0043161,GO:0061631" protein polyubiquitination|protein binding|ATP binding|DNA repair|histone ubiquitination|HULC complex|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin conjugating enzyme activity hsa04120 Ubiquitin mediated proteolysis UBE2V1 73.22084538 67.62690237 78.81478839 1.165435435 0.220869082 0.690521221 1 0.847411009 0.971076622 7335 ubiquitin conjugating enzyme E2 V1 "GO:0000151,GO:0000187,GO:0000209,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006282,GO:0006301,GO:0006355,GO:0007254,GO:0030154,GO:0031371,GO:0032991,GO:0035370,GO:0043123,GO:0045893,GO:0051092,GO:0061631,GO:0070062,GO:0070423,GO:0070498,GO:0070534" "ubiquitin ligase complex|activation of MAPK activity|protein polyubiquitination|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of DNA repair|postreplication repair|regulation of transcription, DNA-templated|JNK cascade|cell differentiation|ubiquitin conjugating enzyme complex|protein-containing complex|UBC13-UEV1A complex|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription, DNA-templated|positive regulation of NF-kappaB transcription factor activity|ubiquitin conjugating enzyme activity|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|protein K63-linked ubiquitination" hsa05131 Shigellosis UBE2V2 1749.725512 1537.731719 1961.719306 1.27572273 0.351314803 0.138769575 1 18.32237455 22.98313293 7336 ubiquitin conjugating enzyme E2 V2 "GO:0000209,GO:0000729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006282,GO:0006301,GO:0006303,GO:0010976,GO:0016567,GO:0031372,GO:0032436,GO:0042275,GO:0043524,GO:0045739,GO:0051965,GO:0061631,GO:0070062,GO:0070534" protein polyubiquitination|DNA double-strand break processing|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of DNA repair|postreplication repair|double-strand break repair via nonhomologous end joining|positive regulation of neuron projection development|protein ubiquitination|UBC13-MMS2 complex|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|error-free postreplication DNA repair|negative regulation of neuron apoptotic process|positive regulation of DNA repair|positive regulation of synapse assembly|ubiquitin conjugating enzyme activity|extracellular exosome|protein K63-linked ubiquitination hsa05131 Shigellosis UBE2W 1393.534171 1346.295564 1440.772778 1.070175685 0.097847656 0.684904858 1 8.133271437 8.558379191 55284 ubiquitin conjugating enzyme E2 W "GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006281,GO:0006513,GO:0006515,GO:0016567,GO:0031625,GO:0043161,GO:0061631,GO:0070979,GO:0071218" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|DNA repair|protein monoubiquitination|protein quality control for misfolded or incompletely synthesized proteins|protein ubiquitination|ubiquitin protein ligase binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin conjugating enzyme activity|protein K11-linked ubiquitination|cellular response to misfolded protein hsa04120 Ubiquitin mediated proteolysis UBE2Z 4478.531407 4807.752552 4149.310262 0.86304572 -0.212491107 0.374052451 1 83.19744404 70.6016687 65264 ubiquitin conjugating enzyme E2 Z "GO:0004869,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0006915,GO:0010951,GO:0016567,GO:0043065,GO:0043066,GO:0061631" cysteine-type endopeptidase inhibitor activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|apoptotic process|negative regulation of endopeptidase activity|protein ubiquitination|positive regulation of apoptotic process|negative regulation of apoptotic process|ubiquitin conjugating enzyme activity hsa04120 Ubiquitin mediated proteolysis UBE3A 1347.869817 1270.345351 1425.394283 1.122052584 0.166140288 0.489956202 1 5.892229843 6.500759031 7337 ubiquitin protein ligase E3A "GO:0000502,GO:0001541,GO:0003713,GO:0004842,GO:0005515,GO:0005634,GO:0005829,GO:0006508,GO:0006511,GO:0007420,GO:0014068,GO:0016032,GO:0030521,GO:0031398,GO:0032570,GO:0035037,GO:0042220,GO:0042542,GO:0042752,GO:0045944,GO:0046872,GO:0048511,GO:0050847,GO:0051865,GO:0060736,GO:0061002,GO:0061630,GO:0070936,GO:1905528,GO:1990416,GO:2000058" proteasome complex|ovarian follicle development|transcription coactivator activity|ubiquitin-protein transferase activity|protein binding|nucleus|cytosol|proteolysis|ubiquitin-dependent protein catabolic process|brain development|positive regulation of phosphatidylinositol 3-kinase signaling|viral process|androgen receptor signaling pathway|positive regulation of protein ubiquitination|response to progesterone|sperm entry|response to cocaine|response to hydrogen peroxide|regulation of circadian rhythm|positive regulation of transcription by RNA polymerase II|metal ion binding|rhythmic process|progesterone receptor signaling pathway|protein autoubiquitination|prostate gland growth|negative regulation of dendritic spine morphogenesis|ubiquitin protein ligase activity|protein K48-linked ubiquitination|positive regulation of Golgi lumen acidification|cellular response to brain-derived neurotrophic factor stimulus|regulation of ubiquitin-dependent protein catabolic process "hsa04120,hsa05165,hsa05203" Ubiquitin mediated proteolysis|Human papillomavirus infection|Viral carcinogenesis UBE3B 1065.706991 1129.889477 1001.524506 0.886391569 -0.173983935 0.477838521 1 9.154413954 7.978611933 89910 ubiquitin protein ligase E3B "GO:0000209,GO:0004842,GO:0006511,GO:0061630" protein polyubiquitination|ubiquitin-protein transferase activity|ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity hsa04120 Ubiquitin mediated proteolysis UBE3C 3394.75741 3392.789671 3396.725148 1.001159953 0.001672489 0.995803209 1 34.66059515 34.12012893 9690 ubiquitin protein ligase E3C "GO:0000209,GO:0000502,GO:0005515,GO:0005634,GO:0006511,GO:0061630" protein polyubiquitination|proteasome complex|protein binding|nucleus|ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity hsa04120 Ubiquitin mediated proteolysis UBE3D 103.3582494 114.4455271 92.27097178 0.806243583 -0.310712323 0.509941442 1 0.81512711 0.6461938 90025 ubiquitin protein ligase E3D "GO:0000151,GO:0000209,GO:0005515,GO:0005634,GO:0005829,GO:0006513,GO:0030332,GO:0031624,GO:0043161,GO:0044390,GO:0051865,GO:0061630" ubiquitin ligase complex|protein polyubiquitination|protein binding|nucleus|cytosol|protein monoubiquitination|cyclin binding|ubiquitin conjugating enzyme binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-like protein conjugating enzyme binding|protein autoubiquitination|ubiquitin protein ligase activity UBE4A 2029.82959 2116.201837 1943.457343 0.918370502 -0.122851792 0.604511983 1 18.55088742 16.75150357 9354 ubiquitination factor E4A "GO:0000151,GO:0000209,GO:0005515,GO:0005634,GO:0005737,GO:0006511,GO:0030433,GO:0034450" ubiquitin ligase complex|protein polyubiquitination|protein binding|nucleus|cytoplasm|ubiquitin-dependent protein catabolic process|ubiquitin-dependent ERAD pathway|ubiquitin-ubiquitin ligase activity hsa04120 Ubiquitin mediated proteolysis UBE4B 1634.925283 1791.592706 1478.25786 0.825108215 -0.277344749 0.243506333 1 13.67086215 11.09118614 10277 ubiquitination factor E4B "GO:0000151,GO:0000209,GO:0005634,GO:0005737,GO:0006511,GO:0008626,GO:0009411,GO:0019899,GO:0030433,GO:0034450,GO:0043161,GO:0051117" ubiquitin ligase complex|protein polyubiquitination|nucleus|cytoplasm|ubiquitin-dependent protein catabolic process|granzyme-mediated apoptotic signaling pathway|response to UV|enzyme binding|ubiquitin-dependent ERAD pathway|ubiquitin-ubiquitin ligase activity|proteasome-mediated ubiquitin-dependent protein catabolic process|ATPase binding "hsa04120,hsa04141" Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum UBFD1 1703.375562 1771.824842 1634.926281 0.922735838 -0.116010404 0.626425512 1 18.69864254 16.96518683 56061 ubiquitin family domain containing 1 "GO:0003723,GO:0045296" RNA binding|cadherin binding UBIAD1 444.1799275 482.7520415 405.6078134 0.840199064 -0.251196916 0.373452079 1 3.083244279 2.547189796 29914 UbiA prenyltransferase domain containing 1 "GO:0004659,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0006744,GO:0009234,GO:0016020,GO:0016209,GO:0030173,GO:0031966,GO:0032194,GO:0042371,GO:0042373,GO:0098869" "prenyltransferase activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|ubiquinone biosynthetic process|menaquinone biosynthetic process|membrane|antioxidant activity|integral component of Golgi membrane|mitochondrial membrane|ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate|vitamin K biosynthetic process|vitamin K metabolic process|cellular oxidant detoxification" UBL3 713.3570866 648.1778489 778.5363244 1.201115289 0.264374635 0.301504991 1 8.012985984 9.46346667 5412 ubiquitin like 3 "GO:0005515,GO:0005886,GO:0070062" protein binding|plasma membrane|extracellular exosome UBL4A 1985.235832 1967.422652 2003.049012 1.018108138 0.025890804 0.915045604 1 45.1215002 45.16984684 8266 ubiquitin like 4A "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006464,GO:0016020,GO:0018215,GO:0019787,GO:0051087,GO:0071816,GO:0071818" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cellular protein modification process|membrane|protein phosphopantetheinylation|ubiquitin-like protein transferase activity|chaperone binding|tail-anchored membrane protein insertion into ER membrane|BAT3 complex UBL5 793.7670944 664.824471 922.7097178 1.387899751 0.472903365 0.060498405 1 87.1755777 118.9663427 59286 ubiquitin like 5 "GO:0000398,GO:0005515,GO:0005634,GO:0005737,GO:0006464,GO:0031386,GO:1903955" "mRNA splicing, via spliceosome|protein binding|nucleus|cytoplasm|cellular protein modification process|protein tag|positive regulation of protein targeting to mitochondrion" UBL7 791.2793018 776.1487565 806.4098471 1.038988777 0.05518007 0.83120966 1 23.25751411 23.75993937 84993 ubiquitin like 7 "GO:0005515,GO:0005829,GO:0006511,GO:0031593" protein binding|cytosol|ubiquitin-dependent protein catabolic process|polyubiquitin modification-dependent protein binding UBLCP1 881.5185212 848.9777282 914.0593141 1.076658767 0.106561079 0.671477661 1 20.79319917 22.01256104 134510 ubiquitin like domain containing CTD phosphatase 1 "GO:0004722,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006470,GO:0106306,GO:0106307" protein serine/threonine phosphatase activity|protein binding|nucleus|nucleoplasm|nucleolus|protein dephosphorylation|protein serine phosphatase activity|protein threonine phosphatase activity UBN1 1152.492232 1326.5277 978.4567632 0.737607487 -0.439074796 0.070628238 1 8.785597582 6.37188313 29855 ubinuclein 1 "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005923,GO:0006336,GO:0016032,GO:0016604,GO:0016605,GO:0034451" DNA binding|protein binding|nucleus|nucleoplasm|bicellular tight junction|DNA replication-independent nucleosome assembly|viral process|nuclear body|PML body|centriolar satellite other UBN2 310.6295538 357.9023756 263.3567319 0.735833987 -0.442547782 0.154961209 1 1.640521514 1.186951441 254048 ubinuclein 2 "GO:0005615,GO:0005654" extracellular space|nucleoplasm UBOX5 211.2995961 185.1936711 237.4055211 1.281931071 0.358318691 0.316358704 1 2.29847578 2.89718204 22888 U-box domain containing 5 "GO:0000209,GO:0005515,GO:0005634,GO:0005654,GO:0005925,GO:0016604,GO:0031625,GO:0034450,GO:0046872" protein polyubiquitination|protein binding|nucleus|nucleoplasm|focal adhesion|nuclear body|ubiquitin protein ligase binding|ubiquitin-ubiquitin ligase activity|metal ion binding hsa04120 Ubiquitin mediated proteolysis UBP1 1947.993554 1961.180169 1934.806939 0.986552368 -0.019532461 0.936508987 1 25.06936075 24.31837671 7342 upstream binding protein 1 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001525,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0032897,GO:0045944,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|negative regulation of viral transcription|positive regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" CP2 UBQLN1 5922.879739 5873.136368 5972.623111 1.016939287 0.024233551 0.920925305 1 62.52513337 62.52026799 29979 ubiquilin 1 "GO:0000045,GO:0000502,GO:0005515,GO:0005654,GO:0005737,GO:0005776,GO:0005783,GO:0005829,GO:0005886,GO:0006511,GO:0016235,GO:0016236,GO:0016241,GO:0019900,GO:0030433,GO:0031396,GO:0031398,GO:0031410,GO:0031593,GO:0032991,GO:0034976,GO:0035973,GO:0042802,GO:0048471,GO:0071456,GO:0097352,GO:1901340,GO:1902175,GO:1903071" autophagosome assembly|proteasome complex|protein binding|nucleoplasm|cytoplasm|autophagosome|endoplasmic reticulum|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|aggresome|macroautophagy|regulation of macroautophagy|kinase binding|ubiquitin-dependent ERAD pathway|regulation of protein ubiquitination|positive regulation of protein ubiquitination|cytoplasmic vesicle|polyubiquitin modification-dependent protein binding|protein-containing complex|response to endoplasmic reticulum stress|aggrephagy|identical protein binding|perinuclear region of cytoplasm|cellular response to hypoxia|autophagosome maturation|negative regulation of store-operated calcium channel activity|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|positive regulation of ER-associated ubiquitin-dependent protein catabolic process "hsa04141,hsa05014" Protein processing in endoplasmic reticulum|Amyotrophic lateral sclerosis UBQLN2 1368.766799 1389.992947 1347.54065 0.969458624 -0.044748768 0.854803162 1 17.48735712 16.66957917 29978 ubiquilin 2 "GO:0000045,GO:0005515,GO:0005634,GO:0005737,GO:0005776,GO:0005829,GO:0005886,GO:0006511,GO:0016241,GO:0030433,GO:0031410,GO:0031593,GO:0042802,GO:1900186,GO:1903071,GO:1904021,GO:2000785" autophagosome assembly|protein binding|nucleus|cytoplasm|autophagosome|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|regulation of macroautophagy|ubiquitin-dependent ERAD pathway|cytoplasmic vesicle|polyubiquitin modification-dependent protein binding|identical protein binding|negative regulation of clathrin-dependent endocytosis|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|negative regulation of G protein-coupled receptor internalization|regulation of autophagosome assembly "hsa04141,hsa05014" Protein processing in endoplasmic reticulum|Amyotrophic lateral sclerosis UBQLN4 1266.666001 1434.730744 1098.601258 0.765719465 -0.385112163 0.11016112 1 20.20288731 15.21087884 56893 ubiquilin 4 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005776,GO:0005789,GO:0005829,GO:0006281,GO:0006511,GO:0006914,GO:0006974,GO:0031410,GO:0031593,GO:0031595,GO:0031597,GO:0032434,GO:0032991,GO:0036435,GO:0042802,GO:0048471,GO:0090734,GO:1901097,GO:2000042" protein binding|nucleus|nucleoplasm|cytoplasm|autophagosome|endoplasmic reticulum membrane|cytosol|DNA repair|ubiquitin-dependent protein catabolic process|autophagy|cellular response to DNA damage stimulus|cytoplasmic vesicle|polyubiquitin modification-dependent protein binding|nuclear proteasome complex|cytosolic proteasome complex|regulation of proteasomal ubiquitin-dependent protein catabolic process|protein-containing complex|K48-linked polyubiquitin modification-dependent protein binding|identical protein binding|perinuclear region of cytoplasm|site of DNA damage|negative regulation of autophagosome maturation|negative regulation of double-strand break repair via homologous recombination "hsa04141,hsa05014" Protein processing in endoplasmic reticulum|Amyotrophic lateral sclerosis UBR1 1057.08677 1054.979677 1059.193864 1.003994567 0.005751462 0.98563433 1 7.313890152 7.220229039 197131 ubiquitin protein ligase E3 component n-recognin 1 "GO:0000151,GO:0000502,GO:0005515,GO:0005737,GO:0005829,GO:0008270,GO:0016567,GO:0032007,GO:0061630,GO:0070728,GO:0071233,GO:0071596" ubiquitin ligase complex|proteasome complex|protein binding|cytoplasm|cytosol|zinc ion binding|protein ubiquitination|negative regulation of TOR signaling|ubiquitin protein ligase activity|leucine binding|cellular response to leucine|ubiquitin-dependent protein catabolic process via the N-end rule pathway UBR2 872.2139325 882.2709725 862.1568925 0.977201925 -0.03327139 0.898384837 1 5.144234705 4.942836754 23304 ubiquitin protein ligase E3 component n-recognin 2 "GO:0000151,GO:0000209,GO:0000785,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006342,GO:0007131,GO:0007140,GO:0007141,GO:0007283,GO:0008270,GO:0010529,GO:0016567,GO:0032007,GO:0033522,GO:0061630,GO:0070728,GO:0071233,GO:0071596" ubiquitin ligase complex|protein polyubiquitination|chromatin|protein binding|nucleus|cytoplasm|cytosol|chromatin silencing|reciprocal meiotic recombination|male meiotic nuclear division|male meiosis I|spermatogenesis|zinc ion binding|negative regulation of transposition|protein ubiquitination|negative regulation of TOR signaling|histone H2A ubiquitination|ubiquitin protein ligase activity|leucine binding|cellular response to leucine|ubiquitin-dependent protein catabolic process via the N-end rule pathway UBR3 672.1512978 638.8141239 705.4884717 1.104372063 0.143226298 0.58152151 1 3.904298638 4.239646234 130507 ubiquitin protein ligase E3 component n-recognin 3 "GO:0000151,GO:0001967,GO:0004842,GO:0005737,GO:0006511,GO:0007608,GO:0008270,GO:0009792,GO:0016021,GO:0016567,GO:0061630,GO:0071596" ubiquitin ligase complex|suckling behavior|ubiquitin-protein transferase activity|cytoplasm|ubiquitin-dependent protein catabolic process|sensory perception of smell|zinc ion binding|embryo development ending in birth or egg hatching|integral component of membrane|protein ubiquitination|ubiquitin protein ligase activity|ubiquitin-dependent protein catabolic process via the N-end rule pathway UBR4 8187.466814 9194.137481 7180.796147 0.781019009 -0.356570432 0.149300841 1 30.64606953 23.53464033 23352 ubiquitin protein ligase E3 component n-recognin 4 "GO:0004842,GO:0005515,GO:0005516,GO:0005654,GO:0005813,GO:0005829,GO:0005886,GO:0006511,GO:0008270,GO:0016020,GO:0016021,GO:0016032,GO:0016567,GO:0035579,GO:0043312,GO:0061630,GO:0070821,GO:0101003" ubiquitin-protein transferase activity|protein binding|calmodulin binding|nucleoplasm|centrosome|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|zinc ion binding|membrane|integral component of membrane|viral process|protein ubiquitination|specific granule membrane|neutrophil degranulation|ubiquitin protein ligase activity|tertiary granule membrane|ficolin-1-rich granule membrane "hsa05165,hsa05203" Human papillomavirus infection|Viral carcinogenesis UBR5 4693.339088 4933.642631 4453.035544 0.902585752 -0.14786409 0.537073898 1 24.86537346 22.06757639 51366 ubiquitin protein ligase E3 component n-recognin 5 "GO:0000209,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006974,GO:0008270,GO:0010628,GO:0016020,GO:0016032,GO:0032991,GO:0034450,GO:0042307,GO:0043130,GO:0048471,GO:0050847,GO:0061630,GO:0070936,GO:0090263,GO:1901315,GO:2000779,GO:2000780" protein polyubiquitination|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|DNA repair|cellular response to DNA damage stimulus|zinc ion binding|positive regulation of gene expression|membrane|viral process|protein-containing complex|ubiquitin-ubiquitin ligase activity|positive regulation of protein import into nucleus|ubiquitin binding|perinuclear region of cytoplasm|progesterone receptor signaling pathway|ubiquitin protein ligase activity|protein K48-linked ubiquitination|positive regulation of canonical Wnt signaling pathway|negative regulation of histone H2A K63-linked ubiquitination|regulation of double-strand break repair|negative regulation of double-strand break repair hsa04120 Ubiquitin mediated proteolysis UBR7 1818.739428 1709.400009 1928.078848 1.127927248 0.173674016 0.464378131 1 26.1097701 28.95711659 55148 ubiquitin protein ligase E3 component n-recognin 7 "GO:0003674,GO:0005737,GO:0008150,GO:0008270,GO:0016567,GO:0061630" molecular_function|cytoplasm|biological_process|zinc ion binding|protein ubiquitination|ubiquitin protein ligase activity UBTD1 1136.456364 1069.545471 1203.367257 1.12512024 0.170079188 0.485519959 1 34.65675535 38.34052155 80019 ubiquitin domain containing 1 GO:0005515 protein binding UBTD2 905.0064771 998.7973273 811.2156269 0.812192428 -0.300106517 0.226676547 1 16.88972676 13.48816092 92181 ubiquitin domain containing 2 "GO:0005515,GO:0005737" protein binding|cytoplasm UBTF 1343.265369 1565.822893 1120.707845 0.71573091 -0.482510808 0.044550965 1 16.05477233 11.29861221 7343 upstream binding transcription factor "GO:0001164,GO:0001165,GO:0001181,GO:0001188,GO:0001650,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006360,GO:0006361,GO:0006362,GO:0006363,GO:0045943,GO:0097110,GO:1902659" RNA polymerase I core promoter sequence-specific DNA binding|RNA polymerase I cis-regulatory region sequence-specific DNA binding|RNA polymerase I general transcription initiation factor activity|RNA polymerase I preinitiation complex assembly|fibrillar center|chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|transcription by RNA polymerase I|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|positive regulation of transcription by RNA polymerase I|scaffold protein binding|regulation of glucose mediated signaling pathway HMG UBXN1 1732.899024 1752.056978 1713.74107 0.9781309 -0.031900545 0.8954642 1 73.97473164 71.14617494 51035 UBX domain protein 1 "GO:0005515,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0006457,GO:0016032,GO:0030425,GO:0031397,GO:0031593,GO:0031625,GO:0032435,GO:0034098,GO:0036435,GO:0043025,GO:0043130,GO:0043161,GO:0051117,GO:0071796,GO:1903094,GO:1904293,GO:1904855,GO:2000157" protein binding|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|protein folding|viral process|dendrite|negative regulation of protein ubiquitination|polyubiquitin modification-dependent protein binding|ubiquitin protein ligase binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|VCP-NPL4-UFD1 AAA ATPase complex|K48-linked polyubiquitin modification-dependent protein binding|neuronal cell body|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ATPase binding|K6-linked polyubiquitin modification-dependent protein binding|negative regulation of protein K48-linked deubiquitination|negative regulation of ERAD pathway|proteasome regulatory particle binding|negative regulation of ubiquitin-specific protease activity hsa04141 Protein processing in endoplasmic reticulum UBXN11 182.6580318 202.8807071 162.4353566 0.800644669 -0.320765987 0.397410656 1 5.170664021 4.070589555 91544 UBX domain protein 11 "GO:0005515,GO:0005737,GO:0005856,GO:0043130,GO:0043161" protein binding|cytoplasm|cytoskeleton|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process UBXN2A 551.0758299 563.9043244 538.2473354 0.954501166 -0.067181134 0.807594569 1 10.10562034 9.484416562 165324 UBX domain protein 2A "GO:0000045,GO:0005515,GO:0005634,GO:0005783,GO:0005801,GO:0005829,GO:0007030,GO:0010468,GO:0031396,GO:0031468,GO:0033130,GO:0042176,GO:0043130,GO:0043161,GO:0061025,GO:1990830" autophagosome assembly|protein binding|nucleus|endoplasmic reticulum|cis-Golgi network|cytosol|Golgi organization|regulation of gene expression|regulation of protein ubiquitination|nuclear envelope reassembly|acetylcholine receptor binding|regulation of protein catabolic process|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|membrane fusion|cellular response to leukemia inhibitory factor hsa04141 Protein processing in endoplasmic reticulum UBXN2B 1527.37581 1642.813521 1411.938099 0.859463403 -0.218491885 0.359838413 1 16.8054319 14.20195871 137886 UBX domain protein 2B "GO:0000045,GO:0000132,GO:0005515,GO:0005634,GO:0005783,GO:0005794,GO:0005829,GO:0007030,GO:0031468,GO:0031616,GO:0043130,GO:0043161,GO:0046604,GO:0061025,GO:1904780" autophagosome assembly|establishment of mitotic spindle orientation|protein binding|nucleus|endoplasmic reticulum|Golgi apparatus|cytosol|Golgi organization|nuclear envelope reassembly|spindle pole centrosome|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of mitotic centrosome separation|membrane fusion|negative regulation of protein localization to centrosome UBXN4 3746.152418 3660.176039 3832.128797 1.046979368 0.066233013 0.781364322 1 51.79975287 53.32575216 23190 UBX domain protein 4 "GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0005829,GO:0006986,GO:0030433" protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|response to unfolded protein|ubiquitin-dependent ERAD pathway hsa04141 Protein processing in endoplasmic reticulum UBXN6 1273.227359 1152.778582 1393.676136 1.208971227 0.273779909 0.256218664 1 23.59864757 28.05267354 80700 UBX domain protein 6 "GO:0005515,GO:0005634,GO:0005737,GO:0005765,GO:0005768,GO:0005815,GO:0005829,GO:0016236,GO:0019898,GO:0031901,GO:0031902,GO:0032510,GO:0032991,GO:0036503,GO:0070062" protein binding|nucleus|cytoplasm|lysosomal membrane|endosome|microtubule organizing center|cytosol|macroautophagy|extrinsic component of membrane|early endosome membrane|late endosome membrane|endosome to lysosome transport via multivesicular body sorting pathway|protein-containing complex|ERAD pathway|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum UBXN7 2522.280552 2566.701048 2477.860055 0.965387089 -0.050820562 0.831204685 1 12.89831615 12.24350274 26043 UBX domain protein 7 "GO:0005515,GO:0005654,GO:0005829,GO:0008134,GO:0016604,GO:0031625,GO:0034098,GO:0043130,GO:0043687" protein binding|nucleoplasm|cytosol|transcription factor binding|nuclear body|ubiquitin protein ligase binding|VCP-NPL4-UFD1 AAA ATPase complex|ubiquitin binding|post-translational protein modification UBXN8 82.34679655 80.11186896 84.58172413 1.055795168 0.078329968 0.900396784 1 1.618865281 1.680589159 7993 UBX domain protein 8 "GO:0000151,GO:0005515,GO:0005654,GO:0005730,GO:0005783,GO:0007338,GO:0030176,GO:0030433,GO:0030674" ubiquitin ligase complex|protein binding|nucleoplasm|nucleolus|endoplasmic reticulum|single fertilization|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|protein-macromolecule adaptor activity hsa04141 Protein processing in endoplasmic reticulum UCHL1 8.447228369 7.282897178 9.61155956 1.31974396 0.400258063 0.833324456 1 0.352379725 0.457269015 7345 ubiquitin C-terminal hydrolase L1 "GO:0004197,GO:0004843,GO:0005515,GO:0005654,GO:0005737,GO:0005789,GO:0005829,GO:0005886,GO:0008242,GO:0016241,GO:0016579,GO:0016874,GO:0018215,GO:0031625,GO:0031694,GO:0043130,GO:0043161,GO:0043407" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleoplasm|cytoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|omega peptidase activity|regulation of macroautophagy|protein deubiquitination|ligase activity|protein phosphopantetheinylation|ubiquitin protein ligase binding|alpha-2A adrenergic receptor binding|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of MAP kinase activity "hsa05012,hsa05022" Parkinson disease|Pathways of neurodegeneration - multiple diseases UCHL3 950.7915615 775.1083426 1126.47478 1.453312677 0.539345129 0.029107252 0.88444427 9.825678778 14.04083069 7347 ubiquitin C-terminal hydrolase L3 "GO:0004843,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0008233,GO:0016567,GO:0016579,GO:0018215,GO:0019784,GO:0030163,GO:0043130,GO:0043687" thiol-dependent ubiquitin-specific protease activity|protein binding|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|peptidase activity|protein ubiquitination|protein deubiquitination|protein phosphopantetheinylation|NEDD8-specific protease activity|protein catabolic process|ubiquitin binding|post-translational protein modification UCHL5 1132.685353 1185.031412 1080.339295 0.911654563 -0.133440821 0.584999706 1 8.648017022 7.752076047 51377 ubiquitin C-terminal hydrolase L5 "GO:0000502,GO:0003723,GO:0004843,GO:0004866,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006281,GO:0006310,GO:0006511,GO:0008234,GO:0010951,GO:0016579,GO:0018215,GO:0031011,GO:0032435,GO:0045880,GO:0061136,GO:0070628" proteasome complex|RNA binding|thiol-dependent ubiquitin-specific protease activity|endopeptidase inhibitor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|DNA repair|DNA recombination|ubiquitin-dependent protein catabolic process|cysteine-type peptidase activity|negative regulation of endopeptidase activity|protein deubiquitination|protein phosphopantetheinylation|Ino80 complex|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of smoothened signaling pathway|regulation of proteasomal protein catabolic process|proteasome binding UCK1 682.9863248 683.5519209 682.4207288 0.998345126 -0.002389456 0.999135245 1 16.55168317 16.24778057 83549 uridine-cytidine kinase 1 "GO:0004849,GO:0005524,GO:0005829,GO:0016301,GO:0016310,GO:0043097,GO:0044206,GO:0044211" uridine kinase activity|ATP binding|cytosol|kinase activity|phosphorylation|pyrimidine nucleoside salvage|UMP salvage|CTP salvage "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes UCK2 1380.092465 1409.760811 1350.424118 0.957910099 -0.062037831 0.798295379 1 14.93080838 14.06304131 7371 uridine-cytidine kinase 2 "GO:0004849,GO:0005524,GO:0005575,GO:0005829,GO:0016301,GO:0016310,GO:0042802,GO:0043097,GO:0044206,GO:0044211" uridine kinase activity|ATP binding|cellular_component|cytosol|kinase activity|phosphorylation|identical protein binding|pyrimidine nucleoside salvage|UMP salvage|CTP salvage "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes UCKL1 945.9606296 837.5331755 1054.388084 1.258920977 0.332187727 0.178953464 1 10.23765604 12.67273002 54963 uridine-cytidine kinase 1 like 1 "GO:0004849,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0016032,GO:0016301,GO:0016310,GO:0043097,GO:0044206,GO:0044211" uridine kinase activity|protein binding|ATP binding|nucleus|cytosol|viral process|kinase activity|phosphorylation|pyrimidine nucleoside salvage|UMP salvage|CTP salvage "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes UCN 25.50020096 26.01034707 24.99005486 0.960773603 -0.057731582 0.998553223 1 1.74606845 1.649504505 7349 urocortin "GO:0001964,GO:0005184,GO:0005515,GO:0005576,GO:0006954,GO:0006979,GO:0007186,GO:0007218,GO:0007565,GO:0007605,GO:0008306,GO:0009060,GO:0010629,GO:0010996,GO:0030157,GO:0030307,GO:0030425,GO:0031064,GO:0031175,GO:0032099,GO:0032355,GO:0032755,GO:0032967,GO:0033138,GO:0034199,GO:0035176,GO:0035483,GO:0042756,GO:0043066,GO:0043117,GO:0043196,GO:0043204,GO:0043679,GO:0043950,GO:0045727,GO:0045740,GO:0045776,GO:0045792,GO:0045944,GO:0046811,GO:0046888,GO:0048265,GO:0051384,GO:0051430,GO:0051431,GO:0051461,GO:0051966,GO:0060452,GO:0060455,GO:0060547,GO:0090280,GO:1901215,GO:2000252,GO:2000987" "startle response|neuropeptide hormone activity|protein binding|extracellular region|inflammatory response|response to oxidative stress|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|female pregnancy|sensory perception of sound|associative learning|aerobic respiration|negative regulation of gene expression|response to auditory stimulus|pancreatic juice secretion|positive regulation of cell growth|dendrite|negative regulation of histone deacetylation|neuron projection development|negative regulation of appetite|response to estradiol|positive regulation of interleukin-6 production|positive regulation of collagen biosynthetic process|positive regulation of peptidyl-serine phosphorylation|activation of protein kinase A activity|social behavior|gastric emptying|drinking behavior|negative regulation of apoptotic process|positive regulation of vascular permeability|varicosity|perikaryon|axon terminus|positive regulation of cAMP-mediated signaling|positive regulation of translation|positive regulation of DNA replication|negative regulation of blood pressure|negative regulation of cell size|positive regulation of transcription by RNA polymerase II|histone deacetylase inhibitor activity|negative regulation of hormone secretion|response to pain|response to glucocorticoid|corticotropin-releasing hormone receptor 1 binding|corticotropin-releasing hormone receptor 2 binding|positive regulation of corticotropin secretion|regulation of synaptic transmission, glutamatergic|positive regulation of cardiac muscle contraction|negative regulation of gastric acid secretion|negative regulation of necrotic cell death|positive regulation of calcium ion import|negative regulation of neuron death|negative regulation of feeding behavior|positive regulation of behavioral fear response" hsa04080 Neuroactive ligand-receptor interaction UCN2 24.90073609 22.88910542 26.91236677 1.175771891 0.233608194 0.809462121 1 0.815453597 0.942743409 90226 urocortin 2 "GO:0005179,GO:0005576,GO:0005615,GO:0007189,GO:0007586,GO:0009755,GO:0031669,GO:0042562,GO:0051429,GO:0051431" hormone activity|extracellular region|extracellular space|adenylate cyclase-activating G protein-coupled receptor signaling pathway|digestion|hormone-mediated signaling pathway|cellular response to nutrient levels|hormone binding|corticotropin-releasing hormone receptor binding|corticotropin-releasing hormone receptor 2 binding hsa04080 Neuroactive ligand-receptor interaction UCP1 39.18912771 44.73779695 33.64045846 0.75194714 -0.411296848 0.547890944 1 0.411721676 0.304412318 7350 uncoupling protein 1 "GO:0002024,GO:0005739,GO:0005743,GO:0006357,GO:0009266,GO:0009409,GO:0016021,GO:0017077,GO:0022857,GO:0031667,GO:0032555,GO:0032870,GO:0034614,GO:0036041,GO:0050873,GO:0070417,GO:0071398,GO:0120162,GO:1901612,GO:1902600,GO:1903426,GO:1990542,GO:1990845" diet induced thermogenesis|mitochondrion|mitochondrial inner membrane|regulation of transcription by RNA polymerase II|response to temperature stimulus|response to cold|integral component of membrane|oxidative phosphorylation uncoupler activity|transmembrane transporter activity|response to nutrient levels|purine ribonucleotide binding|cellular response to hormone stimulus|cellular response to reactive oxygen species|long-chain fatty acid binding|brown fat cell differentiation|cellular response to cold|cellular response to fatty acid|positive regulation of cold-induced thermogenesis|cardiolipin binding|proton transmembrane transport|regulation of reactive oxygen species biosynthetic process|mitochondrial transmembrane transport|adaptive thermogenesis "hsa03320,hsa04371,hsa04714,hsa05016" PPAR signaling pathway|Apelin signaling pathway|Thermogenesis|Huntington disease UCP2 320.5682059 341.2557535 299.8806583 0.878756344 -0.186464896 0.549979715 1 8.888332046 7.679977051 7351 uncoupling protein 2 "GO:0000303,GO:0001666,GO:0005515,GO:0005739,GO:0005743,GO:0007565,GO:0007568,GO:0009409,GO:0010942,GO:0016021,GO:0017077,GO:0032869,GO:0034198,GO:0043066,GO:0051881,GO:0061179,GO:0070542,GO:0071333,GO:0097421,GO:0120162,GO:1902600,GO:1990542,GO:1990845" response to superoxide|response to hypoxia|protein binding|mitochondrion|mitochondrial inner membrane|female pregnancy|aging|response to cold|positive regulation of cell death|integral component of membrane|oxidative phosphorylation uncoupler activity|cellular response to insulin stimulus|cellular response to amino acid starvation|negative regulation of apoptotic process|regulation of mitochondrial membrane potential|negative regulation of insulin secretion involved in cellular response to glucose stimulus|response to fatty acid|cellular response to glucose stimulus|liver regeneration|positive regulation of cold-induced thermogenesis|proton transmembrane transport|mitochondrial transmembrane transport|adaptive thermogenesis UCP3 8.685002149 13.52538047 3.844623824 0.284252545 -1.814754828 0.153112967 1 0.215020762 0.060097435 7352 uncoupling protein 3 "GO:0000303,GO:0001666,GO:0005215,GO:0005515,GO:0005739,GO:0005743,GO:0006629,GO:0006631,GO:0007568,GO:0007584,GO:0007585,GO:0009409,GO:0014823,GO:0016021,GO:0017077,GO:0032868,GO:0032870,GO:0051384,GO:1902600,GO:1990542,GO:1990845" response to superoxide|response to hypoxia|transporter activity|protein binding|mitochondrion|mitochondrial inner membrane|lipid metabolic process|fatty acid metabolic process|aging|response to nutrient|respiratory gaseous exchange by respiratory system|response to cold|response to activity|integral component of membrane|oxidative phosphorylation uncoupler activity|response to insulin|cellular response to hormone stimulus|response to glucocorticoid|proton transmembrane transport|mitochondrial transmembrane transport|adaptive thermogenesis UEVLD 847.2439993 832.3311061 862.1568925 1.03583404 0.050792875 0.843338736 1 9.544473866 9.721053891 55293 UEV and lactate/malate dehyrogenase domains "GO:0003674,GO:0005975,GO:0006464,GO:0008150,GO:0015031,GO:0016616,GO:0019752,GO:0055114,GO:0070062" "molecular_function|carbohydrate metabolic process|cellular protein modification process|biological_process|protein transport|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|carboxylic acid metabolic process|oxidation-reduction process|extracellular exosome" UFC1 1225.853314 1145.495685 1306.210944 1.140301934 0.189415877 0.434159042 1 42.36521093 47.50074403 51506 ubiquitin-fold modifier conjugating enzyme 1 "GO:0005515,GO:0007420,GO:0018215,GO:0034976,GO:0061657,GO:0061709,GO:0070062,GO:0071568,GO:0071569,GO:1990592" protein binding|brain development|protein phosphopantetheinylation|response to endoplasmic reticulum stress|UFM1 conjugating enzyme activity|reticulophagy|extracellular exosome|UFM1 transferase activity|protein ufmylation|protein K69-linked ufmylation UFD1 1175.888296 1108.040785 1243.735807 1.122463924 0.166669077 0.493141455 1 28.85998058 31.85221251 7353 ubiquitin recognition factor in ER associated degradation 1 "GO:0001501,GO:0004843,GO:0005102,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0016579,GO:0018215,GO:0030433,GO:0030970,GO:0031593,GO:0032480,GO:0034098,GO:0036435,GO:0036501,GO:0039536,GO:0044877,GO:0051117,GO:0070987,GO:0071712" "skeletal system development|thiol-dependent ubiquitin-specific protease activity|signaling receptor binding|protein binding|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein deubiquitination|protein phosphopantetheinylation|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|polyubiquitin modification-dependent protein binding|negative regulation of type I interferon production|VCP-NPL4-UFD1 AAA ATPase complex|K48-linked polyubiquitin modification-dependent protein binding|UFD1-NPL4 complex|negative regulation of RIG-I signaling pathway|protein-containing complex binding|ATPase binding|error-free translesion synthesis|ER-associated misfolded protein catabolic process" hsa04141 Protein processing in endoplasmic reticulum UFL1 998.7889943 924.9279417 1072.650047 1.159712015 0.213766593 0.385443292 1 11.68047901 13.31931802 23376 UFM1 specific ligase 1 "GO:0001649,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0006281,GO:0006974,GO:0008284,GO:0010508,GO:0016020,GO:0016570,GO:0018215,GO:0019901,GO:0030218,GO:0031397,GO:0032088,GO:0032434,GO:0032880,GO:0032991,GO:0033146,GO:0034976,GO:0035861,GO:0043005,GO:0043066,GO:0043122,GO:0050727,GO:0060218,GO:0060252,GO:0061666,GO:0061709,GO:0071568,GO:0071569,GO:1902065,GO:1903895,GO:1990592" osteoblast differentiation|protein binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|DNA repair|cellular response to DNA damage stimulus|positive regulation of cell population proliferation|positive regulation of autophagy|membrane|histone modification|protein phosphopantetheinylation|protein kinase binding|erythrocyte differentiation|negative regulation of protein ubiquitination|negative regulation of NF-kappaB transcription factor activity|regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of protein localization|protein-containing complex|regulation of intracellular estrogen receptor signaling pathway|response to endoplasmic reticulum stress|site of double-strand break|neuron projection|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|regulation of inflammatory response|hematopoietic stem cell differentiation|positive regulation of glial cell proliferation|UFM1 ligase activity|reticulophagy|UFM1 transferase activity|protein ufmylation|response to L-glutamate|negative regulation of IRE1-mediated unfolded protein response|protein K69-linked ufmylation UFM1 2139.763675 2012.160449 2267.3669 1.126832058 0.172272514 0.466780728 1 27.97949582 31.00061126 51569 ubiquitin fold modifier 1 "GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0007420,GO:0033146,GO:0034976,GO:0042308,GO:0043066,GO:0061709,GO:0071569,GO:1990592" protein binding|nucleus|cytoplasm|endoplasmic reticulum|brain development|regulation of intracellular estrogen receptor signaling pathway|response to endoplasmic reticulum stress|negative regulation of protein import into nucleus|negative regulation of apoptotic process|reticulophagy|protein ufmylation|protein K69-linked ufmylation UFSP1 9.527271215 10.40413883 8.650403604 0.831438695 -0.266318203 0.910300494 1 0.558039967 0.456212011 402682 UFM1 specific peptidase 1 (inactive) "GO:0003674,GO:0005515,GO:0008150" molecular_function|protein binding|biological_process UFSP2 391.0395615 374.5489978 407.5301253 1.088055576 0.121752248 0.681704205 1 8.466324277 9.057683812 55325 UFM1 specific peptidase 2 "GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0006508,GO:0016790,GO:0033146,GO:0071567" protein binding|nucleus|cytoplasm|endoplasmic reticulum|proteolysis|thiolester hydrolase activity|regulation of intracellular estrogen receptor signaling pathway|UFM1 hydrolase activity UGCG 4033.182732 4243.848227 3822.517237 0.90071959 -0.150850055 0.526803299 1 44.93777382 39.7990166 7357 UDP-glucose ceramide glucosyltransferase "GO:0000139,GO:0005515,GO:0006497,GO:0006679,GO:0006687,GO:0008120,GO:0008544,GO:0009966,GO:0016020,GO:0016021,GO:0030154,GO:0030216,GO:0033210,GO:0048666,GO:0061436,GO:0098856,GO:0102769,GO:1903575" Golgi membrane|protein binding|protein lipidation|glucosylceramide biosynthetic process|glycosphingolipid metabolic process|ceramide glucosyltransferase activity|epidermis development|regulation of signal transduction|membrane|integral component of membrane|cell differentiation|keratinocyte differentiation|leptin-mediated signaling pathway|neuron development|establishment of skin barrier|intestinal lipid absorption|dihydroceramide glucosyltransferase activity|cornified envelope assembly hsa00600 Sphingolipid metabolism UGDH 1687.889469 1541.893374 1833.885564 1.189372492 0.250200614 0.292389114 1 26.61320035 31.12333818 7358 UDP-glucose 6-dehydrogenase "GO:0001702,GO:0003979,GO:0005634,GO:0005654,GO:0005829,GO:0005975,GO:0006024,GO:0006065,GO:0015012,GO:0030206,GO:0034214,GO:0042802,GO:0048666,GO:0051287,GO:0055114,GO:0070062" gastrulation with mouth forming second|UDP-glucose 6-dehydrogenase activity|nucleus|nucleoplasm|cytosol|carbohydrate metabolic process|glycosaminoglycan biosynthetic process|UDP-glucuronate biosynthetic process|heparan sulfate proteoglycan biosynthetic process|chondroitin sulfate biosynthetic process|protein hexamerization|identical protein binding|neuron development|NAD binding|oxidation-reduction process|extracellular exosome "hsa00040,hsa00053,hsa00520" Pentose and glucuronate interconversions|Ascorbate and aldarate metabolism|Amino sugar and nucleotide sugar metabolism UGGT1 4653.420933 5008.552431 4298.289435 0.858189965 -0.220631064 0.356694862 1 22.48462634 18.97318691 56886 UDP-glucose glycoprotein glucosyltransferase 1 "GO:0003980,GO:0005515,GO:0005783,GO:0005788,GO:0005793,GO:0018279,GO:0032991,GO:0044322,GO:0051082,GO:0051084,GO:0070062,GO:0071712,GO:0097359,GO:1904380" UDP-glucose:glycoprotein glucosyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|protein N-linked glycosylation via asparagine|protein-containing complex|endoplasmic reticulum quality control compartment|unfolded protein binding|'de novo' posttranslational protein folding|extracellular exosome|ER-associated misfolded protein catabolic process|UDP-glucosylation|endoplasmic reticulum mannose trimming hsa04141 Protein processing in endoplasmic reticulum UGGT2 1103.870796 1135.091546 1072.650047 0.9449899 -0.081629184 0.740450196 1 9.818111766 9.122761419 55757 UDP-glucose glycoprotein glucosyltransferase 2 "GO:0003980,GO:0005515,GO:0005783,GO:0005788,GO:0005793,GO:0018279,GO:0032991,GO:0044322,GO:0051082,GO:0071712,GO:0097359,GO:1904380" UDP-glucose:glycoprotein glucosyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|protein N-linked glycosylation via asparagine|protein-containing complex|endoplasmic reticulum quality control compartment|unfolded protein binding|ER-associated misfolded protein catabolic process|UDP-glucosylation|endoplasmic reticulum mannose trimming hsa04141 Protein processing in endoplasmic reticulum UGP2 1608.71802 1532.529649 1684.906391 1.09942825 0.136753456 0.566589548 1 28.9413626 31.28650458 7360 UDP-glucose pyrophosphorylase 2 "GO:0003983,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005977,GO:0005978,GO:0006011,GO:0006065,GO:0007420,GO:0042802,GO:0046872,GO:0070062" UTP:glucose-1-phosphate uridylyltransferase activity|protein binding|nucleus|cytoplasm|cytosol|glycogen metabolic process|glycogen biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|brain development|identical protein binding|metal ion binding|extracellular exosome "hsa00040,hsa00052,hsa00500,hsa00520" Pentose and glucuronate interconversions|Galactose metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism UGT2B7 106.8065836 104.0413883 109.571779 1.05315568 0.074718714 0.890737869 1 2.469972274 2.557736677 7364 UDP glucuronosyltransferase family 2 member B7 "GO:0001972,GO:0005789,GO:0006629,GO:0008194,GO:0008209,GO:0008210,GO:0015020,GO:0016020,GO:0016021,GO:0043231,GO:0052695" retinoic acid binding|endoplasmic reticulum membrane|lipid metabolic process|UDP-glycosyltransferase activity|androgen metabolic process|estrogen metabolic process|glucuronosyltransferase activity|membrane|integral component of membrane|intracellular membrane-bounded organelle|cellular glucuronidation "hsa00040,hsa00053,hsa00140,hsa00830,hsa00860,hsa00980,hsa00982,hsa00983,hsa04976,hsa05204" Pentose and glucuronate interconversions|Ascorbate and aldarate metabolism|Steroid hormone biosynthesis|Retinol metabolism|Porphyrin and chlorophyll metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Bile secretion|Chemical carcinogenesis UGT8 924.6164394 933.2512527 915.9816261 0.981495201 -0.026946881 0.917861919 1 5.41309685 5.224023917 7368 UDP glycosyltransferase 8 "GO:0002175,GO:0003851,GO:0005783,GO:0005886,GO:0006682,GO:0006687,GO:0007010,GO:0007417,GO:0007422,GO:0008194,GO:0008489,GO:0016021,GO:0030913,GO:0043231,GO:0047263,GO:0048812" "protein localization to paranode region of axon|2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|endoplasmic reticulum|plasma membrane|galactosylceramide biosynthetic process|glycosphingolipid metabolic process|cytoskeleton organization|central nervous system development|peripheral nervous system development|UDP-glycosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity|integral component of membrane|paranodal junction assembly|intracellular membrane-bounded organelle|N-acylsphingosine galactosyltransferase activity|neuron projection morphogenesis" "hsa00565,hsa00600" Ether lipid metabolism|Sphingolipid metabolism UHMK1 5468.625953 5643.204899 5294.047006 0.938127731 -0.092143729 0.702620751 1 34.77684454 32.07918501 127933 U2AF homology motif kinase 1 "GO:0003723,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005794,GO:0007050,GO:0016740,GO:0018105,GO:0030424,GO:0030496,GO:0031175,GO:0032839,GO:0043021,GO:0045948,GO:0046777,GO:0046825,GO:0071598,GO:0106310,GO:0106311" RNA binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|Golgi apparatus|cell cycle arrest|transferase activity|peptidyl-serine phosphorylation|axon|midbody|neuron projection development|dendrite cytoplasm|ribonucleoprotein complex binding|positive regulation of translational initiation|protein autophosphorylation|regulation of protein export from nucleus|neuronal ribonucleoprotein granule|protein serine kinase activity|protein threonine kinase activity UHRF1 943.5816631 976.9486358 910.2146903 0.931691449 -0.102075842 0.682397942 1 11.10499534 10.17329572 29128 ubiquitin like with PHD and ring finger domains 1 "GO:0000122,GO:0000785,GO:0000791,GO:0000792,GO:0000987,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0006281,GO:0006511,GO:0007049,GO:0008270,GO:0008327,GO:0010216,GO:0010390,GO:0016363,GO:0016567,GO:0016574,GO:0031493,GO:0032270,GO:0035064,GO:0042393,GO:0042802,GO:0044729,GO:0045944,GO:0050678,GO:0051865,GO:0061630,GO:2000373" negative regulation of transcription by RNA polymerase II|chromatin|euchromatin|heterochromatin|cis-regulatory region sequence-specific DNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|replication fork|DNA repair|ubiquitin-dependent protein catabolic process|cell cycle|zinc ion binding|methyl-CpG binding|maintenance of DNA methylation|histone monoubiquitination|nuclear matrix|protein ubiquitination|histone ubiquitination|nucleosomal histone binding|positive regulation of cellular protein metabolic process|methylated histone binding|histone binding|identical protein binding|hemi-methylated DNA-binding|positive regulation of transcription by RNA polymerase II|regulation of epithelial cell proliferation|protein autoubiquitination|ubiquitin protein ligase activity|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity UHRF1BP1 968.4566327 1163.182721 773.7305446 0.665184008 -0.58817461 0.017124121 0.770503287 6.488650985 4.243921998 54887 UHRF1 binding protein 1 "GO:0005515,GO:0042802,GO:0042826" protein binding|identical protein binding|histone deacetylase binding UHRF1BP1L 1075.765145 1015.443949 1136.08634 1.118807533 0.161961873 0.508742603 1 6.390610528 7.030219921 23074 UHRF1 binding protein 1 like "GO:0005515,GO:0005769,GO:0005829,GO:0042803,GO:0062069" protein binding|early endosome|cytosol|protein homodimerization activity|GARP complex binding UHRF2 1280.302051 1187.11224 1373.491861 1.157002527 0.210392015 0.383150301 1 16.44704009 18.71083793 115426 ubiquitin like with PHD and ring finger domains 2 "GO:0000792,GO:0003677,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005721,GO:0007049,GO:0008134,GO:0010216,GO:0016567,GO:0030154,GO:0042393,GO:0046872,GO:0051726,GO:0051865,GO:0061630,GO:0071158" heterochromatin|DNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|pericentric heterochromatin|cell cycle|transcription factor binding|maintenance of DNA methylation|protein ubiquitination|cell differentiation|histone binding|metal ion binding|regulation of cell cycle|protein autoubiquitination|ubiquitin protein ligase activity|positive regulation of cell cycle arrest UIMC1 721.6898441 740.7746844 702.6050038 0.948473292 -0.076320945 0.769142112 1 12.20932163 11.38643626 51720 ubiquitin interaction motif containing 1 "GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006302,GO:0006303,GO:0010212,GO:0016579,GO:0016604,GO:0042393,GO:0045739,GO:0045892,GO:0046872,GO:0070530,GO:0070531,GO:0070537,GO:0072425" "DNA binding|protein binding|nucleus|nucleoplasm|double-strand break repair|double-strand break repair via nonhomologous end joining|response to ionizing radiation|protein deubiquitination|nuclear body|histone binding|positive regulation of DNA repair|negative regulation of transcription, DNA-templated|metal ion binding|K63-linked polyubiquitin modification-dependent protein binding|BRCA1-A complex|histone H2A K63-linked deubiquitination|signal transduction involved in G2 DNA damage checkpoint" hsa03440 Homologous recombination ULBP1 30.69723996 48.89945248 12.49502743 0.255524894 -1.968464243 0.008036568 0.553766277 0.812729338 0.204197459 80329 UL16 binding protein 1 "GO:0005515,GO:0005615,GO:0005783,GO:0005829,GO:0005886,GO:0006955,GO:0009897,GO:0016032,GO:0030101,GO:0042267,GO:0046658,GO:0046703,GO:0050776" protein binding|extracellular space|endoplasmic reticulum|cytosol|plasma membrane|immune response|external side of plasma membrane|viral process|natural killer cell activation|natural killer cell mediated cytotoxicity|anchored component of plasma membrane|natural killer cell lectin-like receptor binding|regulation of immune response hsa04650 Natural killer cell mediated cytotoxicity ULBP2 235.7644136 196.6382238 274.8906034 1.397951009 0.483313803 0.157917384 1 7.485178744 10.28881376 80328 UL16 binding protein 2 "GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0005886,GO:0006955,GO:0009897,GO:0009986,GO:0016032,GO:0030101,GO:0042267,GO:0046658,GO:0046703" protein binding|extracellular region|extracellular space|endoplasmic reticulum|plasma membrane|immune response|external side of plasma membrane|cell surface|viral process|natural killer cell activation|natural killer cell mediated cytotoxicity|anchored component of plasma membrane|natural killer cell lectin-like receptor binding hsa04650 Natural killer cell mediated cytotoxicity ULBP3 161.6415485 181.0320156 142.2510815 0.785778587 -0.34780524 0.381149225 1 3.105543539 2.399435008 79465 UL16 binding protein 3 "GO:0005515,GO:0005615,GO:0005886,GO:0006955,GO:0009897,GO:0016032,GO:0030101,GO:0042267,GO:0046658,GO:0046703,GO:0050776" protein binding|extracellular space|plasma membrane|immune response|external side of plasma membrane|viral process|natural killer cell activation|natural killer cell mediated cytotoxicity|anchored component of plasma membrane|natural killer cell lectin-like receptor binding|regulation of immune response hsa04650 Natural killer cell mediated cytotoxicity ULK1 1227.206344 1067.464644 1386.948044 1.299291787 0.377725459 0.118159978 1 10.56735784 13.50032694 8408 unc-51 like autophagy activating kinase 1 "GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005741,GO:0005776,GO:0005789,GO:0005829,GO:0006468,GO:0006914,GO:0007165,GO:0008104,GO:0010508,GO:0016236,GO:0016241,GO:0016301,GO:0018105,GO:0018107,GO:0030424,GO:0031102,GO:0031175,GO:0031267,GO:0031333,GO:0031669,GO:0032045,GO:0034045,GO:0042594,GO:0042802,GO:0044877,GO:0046777,GO:0048675,GO:0051020,GO:0055037,GO:0075044,GO:0097629,GO:0097632,GO:0097635,GO:0106310,GO:0106311,GO:1990316,GO:2000786" protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|mitochondrial outer membrane|autophagosome|endoplasmic reticulum membrane|cytosol|protein phosphorylation|autophagy|signal transduction|protein localization|positive regulation of autophagy|macroautophagy|regulation of macroautophagy|kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|axon|neuron projection regeneration|neuron projection development|small GTPase binding|negative regulation of protein-containing complex assembly|cellular response to nutrient levels|guanyl-nucleotide exchange factor complex|phagophore assembly site membrane|response to starvation|identical protein binding|protein-containing complex binding|protein autophosphorylation|axon extension|GTPase binding|recycling endosome|positive regulation by symbiont of host autophagy|extrinsic component of omegasome membrane|extrinsic component of phagophore assembly site membrane|extrinsic component of autophagosome membrane|protein serine kinase activity|protein threonine kinase activity|Atg1/ULK1 kinase complex|positive regulation of autophagosome assembly "hsa04137,hsa04140,hsa04150,hsa04152,hsa04211,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022" Mitophagy - animal|Autophagy - animal|mTOR signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ULK2 237.3099432 237.2143652 237.4055211 1.000805836 0.001162108 1 1 1.370541809 1.348693599 9706 unc-51 like autophagy activating kinase 2 "GO:0004674,GO:0005515,GO:0005524,GO:0006914,GO:0007165,GO:0030659,GO:0034045,GO:0042594,GO:0046777,GO:0048675,GO:0075044,GO:0106310,GO:0106311" protein serine/threonine kinase activity|protein binding|ATP binding|autophagy|signal transduction|cytoplasmic vesicle membrane|phagophore assembly site membrane|response to starvation|protein autophosphorylation|axon extension|positive regulation by symbiont of host autophagy|protein serine kinase activity|protein threonine kinase activity "hsa04136,hsa04140,hsa04150,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022" Autophagy - other|Autophagy - animal|mTOR signaling pathway|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases ULK3 268.2103584 278.8309205 257.5897962 0.923820772 -0.11431511 0.735471785 1 5.430910131 4.933231749 25989 unc-51 like kinase 3 "GO:0000407,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0006914,GO:0007224,GO:0045879,GO:0045880,GO:0046777,GO:0072537,GO:0090398,GO:0097542,GO:0106310,GO:0106311" phagophore assembly site|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|autophagy|smoothened signaling pathway|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway|protein autophosphorylation|fibroblast activation|cellular senescence|ciliary tip|protein serine kinase activity|protein threonine kinase activity ULK4 78.66571899 71.7885579 85.54288008 1.191594908 0.252893864 0.634554525 1 0.618437997 0.724596084 54986 unc-51 like kinase 4 "GO:0000226,GO:0005524,GO:0006468,GO:0010975,GO:0043408,GO:0046328,GO:0090036,GO:0106310,GO:0106311,GO:1900744,GO:2001222" microtubule cytoskeleton organization|ATP binding|protein phosphorylation|regulation of neuron projection development|regulation of MAPK cascade|regulation of JNK cascade|regulation of protein kinase C signaling|protein serine kinase activity|protein threonine kinase activity|regulation of p38MAPK cascade|regulation of neuron migration UMAD1 452.8756049 370.3873422 535.3638675 1.445416207 0.531484976 0.05764833 1 8.451001159 12.01080898 729852 UBAP1-MVB12-associated (UMA) domain containing 1 GO:0005515 protein binding UMPS 536.7125964 628.4099851 445.0152076 0.708160625 -0.497851466 0.064023054 1 5.041654531 3.510557066 7372 uridine monophosphate synthetase "GO:0004588,GO:0004590,GO:0005634,GO:0005737,GO:0005829,GO:0006207,GO:0006222,GO:0007565,GO:0007595,GO:0019856,GO:0035690,GO:0044205,GO:0046134" orotate phosphoribosyltransferase activity|orotidine-5'-phosphate decarboxylase activity|nucleus|cytoplasm|cytosol|'de novo' pyrimidine nucleobase biosynthetic process|UMP biosynthetic process|female pregnancy|lactation|pyrimidine nucleobase biosynthetic process|cellular response to drug|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes UNC119 514.0518183 512.9240441 515.1795924 1.004397431 0.006330244 0.989586052 1 16.25523368 16.05350949 9094 unc-119 lipid binding chaperone "GO:0000281,GO:0000922,GO:0005515,GO:0005813,GO:0005829,GO:0006897,GO:0007268,GO:0007399,GO:0007601,GO:0007602,GO:0008289,GO:0042953,GO:0045171,GO:0045202,GO:0051233,GO:0061098,GO:1900186,GO:2001287" mitotic cytokinesis|spindle pole|protein binding|centrosome|cytosol|endocytosis|chemical synaptic transmission|nervous system development|visual perception|phototransduction|lipid binding|lipoprotein transport|intercellular bridge|synapse|spindle midzone|positive regulation of protein tyrosine kinase activity|negative regulation of clathrin-dependent endocytosis|negative regulation of caveolin-mediated endocytosis UNC119B 1083.831175 974.867808 1192.794541 1.223544907 0.291067053 0.233341169 1 11.87557708 14.28715693 84747 unc-119 lipid binding chaperone B "GO:0005515,GO:0005829,GO:0005929,GO:0007399,GO:0008289,GO:0035869,GO:0042953,GO:0060271" protein binding|cytosol|cilium|nervous system development|lipid binding|ciliary transition zone|lipoprotein transport|cilium assembly UNC13B 1148.048757 1222.486312 1073.611203 0.878219406 -0.187346681 0.441569594 1 3.030135509 2.616593504 10497 unc-13 homolog B "GO:0005509,GO:0005515,GO:0005516,GO:0005543,GO:0005794,GO:0005829,GO:0005886,GO:0007268,GO:0007269,GO:0007528,GO:0010808,GO:0014047,GO:0016020,GO:0016081,GO:0016082,GO:0016188,GO:0017075,GO:0019992,GO:0030672,GO:0030742,GO:0031267,GO:0031594,GO:0035249,GO:0035556,GO:0042734,GO:0043065,GO:0043195,GO:0048786,GO:0050714,GO:0060478,GO:0061789,GO:0071333,GO:0097151,GO:0098831,GO:0099011,GO:0099525" "calcium ion binding|protein binding|calmodulin binding|phospholipid binding|Golgi apparatus|cytosol|plasma membrane|chemical synaptic transmission|neurotransmitter secretion|neuromuscular junction development|positive regulation of synaptic vesicle priming|glutamate secretion|membrane|synaptic vesicle docking|synaptic vesicle priming|synaptic vesicle maturation|syntaxin-1 binding|diacylglycerol binding|synaptic vesicle membrane|GTP-dependent protein binding|small GTPase binding|neuromuscular junction|synaptic transmission, glutamatergic|intracellular signal transduction|presynaptic membrane|positive regulation of apoptotic process|terminal bouton|presynaptic active zone|positive regulation of protein secretion|acrosomal vesicle exocytosis|dense core granule priming|cellular response to glucose stimulus|positive regulation of inhibitory postsynaptic potential|presynaptic active zone cytoplasmic component|neuronal dense core vesicle exocytosis|presynaptic dense core vesicle exocytosis" hsa04721 Synaptic vesicle cycle UNC13D 62.37072712 60.34400519 64.39744905 1.067172271 0.093793085 0.894546543 1 0.789325649 0.828250919 201294 unc-13 homolog D "GO:0002432,GO:0002467,GO:0005515,GO:0005576,GO:0005764,GO:0005770,GO:0005829,GO:0006909,GO:0016020,GO:0031267,GO:0033093,GO:0035578,GO:0043231,GO:0043304,GO:0043312,GO:0043320,GO:0045921,GO:0046872,GO:0051607,GO:0055037,GO:0070382,GO:1900026,GO:1903307" granuloma formation|germinal center formation|protein binding|extracellular region|lysosome|late endosome|cytosol|phagocytosis|membrane|small GTPase binding|Weibel-Palade body|azurophil granule lumen|intracellular membrane-bounded organelle|regulation of mast cell degranulation|neutrophil degranulation|natural killer cell degranulation|positive regulation of exocytosis|metal ion binding|defense response to virus|recycling endosome|exocytic vesicle|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of regulated secretory pathway UNC45A 1859.314955 1891.472439 1827.157472 0.965997408 -0.049908777 0.835139551 1 24.00009693 22.79607805 55898 unc-45 myosin chaperone A "GO:0005515,GO:0005794,GO:0005829,GO:0007517,GO:0016607,GO:0030154,GO:0045296,GO:0048471,GO:0051879,GO:0061077" protein binding|Golgi apparatus|cytosol|muscle organ development|nuclear speck|cell differentiation|cadherin binding|perinuclear region of cytoplasm|Hsp90 protein binding|chaperone-mediated protein folding UNC50 701.9024731 650.2586767 753.5462695 1.158840776 0.212682355 0.407734457 1 27.36838363 31.18488133 25972 unc-50 inner nuclear membrane RNA binding protein "GO:0003723,GO:0005515,GO:0005637,GO:0006810,GO:0015031,GO:0030173" RNA binding|protein binding|nuclear inner membrane|transport|protein transport|integral component of Golgi membrane UNC5B 31.05893104 45.77821084 16.33965125 0.356930753 -1.486283887 0.0399619 1 0.501560044 0.17602651 219699 unc-5 netrin receptor B "GO:0001525,GO:0005042,GO:0005515,GO:0005886,GO:0006915,GO:0007411,GO:0014068,GO:0016021,GO:0033564,GO:0038007,GO:0043524,GO:0045121,GO:2001240" angiogenesis|netrin receptor activity|protein binding|plasma membrane|apoptotic process|axon guidance|positive regulation of phosphatidylinositol 3-kinase signaling|integral component of membrane|anterior/posterior axon guidance|netrin-activated signaling pathway|negative regulation of neuron apoptotic process|membrane raft|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand hsa04360 Axon guidance UNC5CL 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.052780396 0.079906167 222643 unc-5 family C-terminal like "GO:0005042,GO:0005515,GO:0005737,GO:0006508,GO:0008233,GO:0016020,GO:0016021,GO:0038007,GO:0043123,GO:0046330" netrin receptor activity|protein binding|cytoplasm|proteolysis|peptidase activity|membrane|integral component of membrane|netrin-activated signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of JNK cascade UNC93B1 387.1502783 385.9935505 388.3070062 1.005993509 0.008620996 0.986509144 1 8.975933055 8.87863008 81622 "unc-93 homolog B1, TLR signaling regulator" "GO:0000139,GO:0002224,GO:0002250,GO:0005515,GO:0005764,GO:0005768,GO:0005783,GO:0005789,GO:0006886,GO:0016021,GO:0032009,GO:0034138,GO:0034154,GO:0034162,GO:0035325,GO:0045087,GO:0051607" Golgi membrane|toll-like receptor signaling pathway|adaptive immune response|protein binding|lysosome|endosome|endoplasmic reticulum|endoplasmic reticulum membrane|intracellular protein transport|integral component of membrane|early phagosome|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway|Toll-like receptor binding|innate immune response|defense response to virus UNG 703.7455271 648.1778489 759.3132052 1.171458121 0.22830538 0.373699959 1 14.9878945 17.26388655 7374 uracil DNA glycosylase "GO:0003684,GO:0004844,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006281,GO:0006284,GO:0016032,GO:0016446,GO:0043024,GO:0043066,GO:0045008,GO:0045190,GO:0097510" "damaged DNA binding|uracil DNA N-glycosylase activity|protein binding|nucleus|nucleoplasm|mitochondrion|DNA repair|base-excision repair|viral process|somatic hypermutation of immunoglobulin genes|ribosomal small subunit binding|negative regulation of apoptotic process|depyrimidination|isotype switching|base-excision repair, AP site formation via deaminated base removal" "hsa03410,hsa05340" Base excision repair|Primary immunodeficiency UNK 828.848058 866.6647642 791.0313518 0.912730486 -0.131739175 0.601575041 1 5.458787396 4.89902793 85451 unk zinc finger "GO:0001701,GO:0001764,GO:0003723,GO:0005737,GO:0005844,GO:0046872,GO:0048667,GO:1905538,GO:1990715,GO:2000766" in utero embryonic development|neuron migration|RNA binding|cytoplasm|polysome|metal ion binding|cell morphogenesis involved in neuron differentiation|polysome binding|mRNA CDS binding|negative regulation of cytoplasmic translation UNKL 270.0433515 301.720026 238.3666771 0.790026039 -0.34002789 0.298899693 1 2.465887174 1.91551601 64718 unk like zinc finger "GO:0000209,GO:0005515,GO:0005634,GO:0005829,GO:0016740,GO:0046872" protein polyubiquitination|protein binding|nucleus|cytosol|transferase activity|metal ion binding UPF1 1678.752228 1756.218634 1601.285823 0.911780454 -0.133241613 0.575969401 1 15.88848291 14.24439104 5976 UPF1 RNA helicase and ATPase "GO:0000184,GO:0000294,GO:0000781,GO:0000785,GO:0000932,GO:0000956,GO:0003682,GO:0003723,GO:0003724,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006260,GO:0006281,GO:0006406,GO:0006449,GO:0008270,GO:0009048,GO:0016032,GO:0032201,GO:0032204,GO:0035145,GO:0042162,GO:0044530,GO:0044770,GO:0061014,GO:0061158,GO:0071044,GO:0071222,GO:0071347" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay|chromosome, telomeric region|chromatin|P-body|nuclear-transcribed mRNA catabolic process|chromatin binding|RNA binding|RNA helicase activity|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA replication|DNA repair|mRNA export from nucleus|regulation of translational termination|zinc ion binding|dosage compensation by inactivation of X chromosome|viral process|telomere maintenance via semi-conservative replication|regulation of telomere maintenance|exon-exon junction complex|telomeric DNA binding|supraspliceosomal complex|cell cycle phase transition|positive regulation of mRNA catabolic process|3'-UTR-mediated mRNA destabilization|histone mRNA catabolic process|cellular response to lipopolysaccharide|cellular response to interleukin-1" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway UPF2 792.3838823 817.7653118 767.0024529 0.937924906 -0.092455676 0.717204614 1 7.169809709 6.612213626 26019 UPF2 regulator of nonsense mediated mRNA decay "GO:0000184,GO:0001889,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0006406,GO:0031100,GO:0035145,GO:0036464,GO:0042162,GO:0048471" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|liver development|RNA binding|protein binding|nucleus|cytoplasm|cytosol|polysome|mRNA export from nucleus|animal organ regeneration|exon-exon junction complex|cytoplasmic ribonucleoprotein granule|telomeric DNA binding|perinuclear region of cytoplasm" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway UPF3A 699.593318 715.8047513 683.3818847 0.954704315 -0.066874115 0.798854384 1 7.545167683 7.082864932 65110 UPF3A regulator of nonsense mediated mRNA decay "GO:0000184,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006913,GO:0017056,GO:0035145,GO:0042162,GO:0043231,GO:0045727,GO:0051028" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|nucleocytoplasmic transport|structural constituent of nuclear pore|exon-exon junction complex|telomeric DNA binding|intracellular membrane-bounded organelle|positive regulation of translation|mRNA transport" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway UPF3B 564.115602 603.4400519 524.791152 0.869665761 -0.201467059 0.451140785 1 10.38854403 8.883379906 65109 UPF3B regulator of nonsense mediated mRNA decay "GO:0000184,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006405,GO:0006406,GO:0017056,GO:0031124,GO:0034451,GO:0035145,GO:0045727" "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|structural constituent of nuclear pore|mRNA 3'-end processing|centriolar satellite|exon-exon junction complex|positive regulation of translation" "hsa03013,hsa03015" RNA transport|mRNA surveillance pathway UPK2 3.443303773 2.080827765 4.80577978 2.309551929 1.207612985 0.648665767 1 0.118897166 0.270004135 7379 uroplakin 2 "GO:0005515,GO:0005887,GO:0007275,GO:0016324,GO:0030855,GO:0070062" protein binding|integral component of plasma membrane|multicellular organism development|apical plasma membrane|epithelial cell differentiation|extracellular exosome UPK3BL2 15.65086762 19.76786377 11.53387147 0.583465751 -0.777280123 0.427928737 1 0.568106924 0.325924216 107983993 uroplakin 3B like 2 GO:0016021 integral component of membrane UPP1 1561.144602 1721.884976 1400.404228 0.813297199 -0.29814545 0.210722796 1 38.25721751 30.59382903 7378 uridine phosphorylase 1 "GO:0004850,GO:0005654,GO:0005829,GO:0006139,GO:0006218,GO:0009032,GO:0042149,GO:0042802,GO:0043097,GO:0044206,GO:0046050,GO:0046074,GO:0046135" uridine phosphorylase activity|nucleoplasm|cytosol|nucleobase-containing compound metabolic process|uridine catabolic process|thymidine phosphorylase activity|cellular response to glucose starvation|identical protein binding|pyrimidine nucleoside salvage|UMP salvage|UMP catabolic process|dTMP catabolic process|pyrimidine nucleoside catabolic process "hsa00240,hsa00983" Pyrimidine metabolism|Drug metabolism - other enzymes UPRT 304.3675632 294.4371288 314.2979976 1.067453683 0.094173473 0.772378626 1 3.561552224 3.738174198 139596 uracil phosphoribosyltransferase homolog "GO:0005515,GO:0005525,GO:0005654,GO:0005829,GO:0006222,GO:0007565,GO:0007595,GO:0009116,GO:0016301,GO:0016310,GO:0032868,GO:0043231" protein binding|GTP binding|nucleoplasm|cytosol|UMP biosynthetic process|female pregnancy|lactation|nucleoside metabolic process|kinase activity|phosphorylation|response to insulin|intracellular membrane-bounded organelle hsa00240 Pyrimidine metabolism UQCC1 1092.108598 1204.799276 979.4179192 0.812930368 -0.298796312 0.220699015 1 24.94100971 19.93602445 55245 ubiquinol-cytochrome c reductase complex assembly factor 1 "GO:0005515,GO:0005743,GO:0031410,GO:0034551,GO:0070131" protein binding|mitochondrial inner membrane|cytoplasmic vesicle|mitochondrial respiratory chain complex III assembly|positive regulation of mitochondrial translation UQCC2 449.0158898 407.842242 490.1895376 1.201909678 0.265328483 0.345780734 1 16.95155052 20.03329743 84300 ubiquinol-cytochrome c reductase complex assembly factor 2 "GO:0002082,GO:0005515,GO:0005739,GO:0005743,GO:0005758,GO:0005759,GO:0016604,GO:0034551,GO:0042645,GO:0050796,GO:0070131,GO:1903364,GO:2001014" regulation of oxidative phosphorylation|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|nuclear body|mitochondrial respiratory chain complex III assembly|mitochondrial nucleoid|regulation of insulin secretion|positive regulation of mitochondrial translation|positive regulation of cellular protein catabolic process|regulation of skeletal muscle cell differentiation UQCC3 237.0771998 218.4869154 255.6674843 1.170172978 0.226721808 0.511765973 1 6.050983451 6.962211442 790955 ubiquinol-cytochrome c reductase complex assembly factor 3 "GO:0005654,GO:0005739,GO:0005750,GO:0005829,GO:0006122,GO:0006754,GO:0031305,GO:0034551,GO:0042407,GO:0070300,GO:1901612" "nucleoplasm|mitochondrion|mitochondrial respiratory chain complex III|cytosol|mitochondrial electron transport, ubiquinol to cytochrome c|ATP biosynthetic process|integral component of mitochondrial inner membrane|mitochondrial respiratory chain complex III assembly|cristae formation|phosphatidic acid binding|cardiolipin binding" UQCR10 1228.994678 1101.798302 1356.191054 1.230888677 0.299700289 0.215080828 1 64.19317723 77.69245175 29796 "ubiquinol-cytochrome c reductase, complex III subunit X" "GO:0005743,GO:0005750,GO:0006122,GO:0008121,GO:0009060,GO:0016021" "mitochondrial inner membrane|mitochondrial respiratory chain complex III|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|aerobic respiration|integral component of membrane" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases UQCR11 1018.9783 912.4429751 1125.513624 1.233516675 0.302777218 0.217481857 1 37.48683955 45.46686716 10975 "ubiquinol-cytochrome c reductase, complex III subunit XI" "GO:0005743,GO:0006091,GO:0006122,GO:0008121,GO:0009055,GO:0016021,GO:0070469" "mitochondrial inner membrane|generation of precursor metabolites and energy|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|electron transfer activity|integral component of membrane|respirasome" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases UQCRB 3246.509721 2869.461488 3623.557954 1.262800692 0.336626957 0.15563938 1 17.58184682 21.83084177 7381 ubiquinol-cytochrome c reductase binding protein "GO:0005515,GO:0005743,GO:0005746,GO:0005750,GO:0006119,GO:0006122,GO:0009060,GO:0055114" "protein binding|mitochondrial inner membrane|mitochondrial respirasome|mitochondrial respiratory chain complex III|oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration|oxidation-reduction process" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases UQCRC1 3447.40395 3235.687175 3659.120724 1.130863562 0.17742488 0.454849079 1 108.2650016 120.3841958 7384 ubiquinol-cytochrome c reductase core protein 1 "GO:0005515,GO:0005739,GO:0005743,GO:0005746,GO:0005750,GO:0006119,GO:0006122,GO:0008121,GO:0009060,GO:0014823,GO:0031625,GO:0043279,GO:0044877,GO:0046872,GO:0055114" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respirasome|mitochondrial respiratory chain complex III|oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|aerobic respiration|response to activity|ubiquitin protein ligase binding|response to alkaloid|protein-containing complex binding|metal ion binding|oxidation-reduction process" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases UQCRC2 3171.330122 3091.069645 3251.590599 1.051930552 0.073039462 0.758802068 1 86.18845654 89.14712691 7385 ubiquinol-cytochrome c reductase core protein 2 "GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005750,GO:0005751,GO:0006119,GO:0006122,GO:0006508,GO:0009060,GO:0042493,GO:0044877,GO:0046872" "protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex III|mitochondrial respiratory chain complex IV|oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c|proteolysis|aerobic respiration|response to drug|protein-containing complex binding|metal ion binding" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases UQCRFS1 1203.88132 1010.24188 1397.52076 1.383352628 0.468168959 0.053213327 1 17.4707558 23.76379359 7386 "ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1" "GO:0005515,GO:0005739,GO:0005743,GO:0005750,GO:0005751,GO:0006122,GO:0008121,GO:0016021,GO:0016491,GO:0022904,GO:0034551,GO:0046872,GO:0051537" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex III|mitochondrial respiratory chain complex IV|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|integral component of membrane|oxidoreductase activity|respiratory electron transport chain|mitochondrial respiratory chain complex III assembly|metal ion binding|2 iron, 2 sulfur cluster binding" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases UQCRH 2857.827161 2708.197337 3007.456986 1.110501419 0.151211237 0.523217366 1 210.9949115 230.3892857 7388 ubiquinol-cytochrome c reductase hinge protein "GO:0005515,GO:0005739,GO:0005743,GO:0005746,GO:0005750,GO:0006119,GO:0006122,GO:0008121,GO:0009060,GO:0055114" "protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respirasome|mitochondrial respiratory chain complex III|oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|aerobic respiration|oxidation-reduction process" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases UQCRHL 86.71162731 81.15228285 92.27097178 1.137010181 0.185245172 0.724005642 1 8.050089561 8.999870161 440567 ubiquinol-cytochrome c reductase hinge protein like "GO:0005750,GO:0006122,GO:0008121,GO:0009060" "mitochondrial respiratory chain complex III|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|aerobic respiration" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases UQCRQ 875.4798275 728.2897178 1022.669937 1.404207573 0.489756214 0.049327866 1 24.70914412 34.11616389 27089 ubiquinol-cytochrome c reductase complex III subunit VII "GO:0005739,GO:0005743,GO:0005750,GO:0006122,GO:0008121,GO:0016021,GO:0021539,GO:0021548,GO:0021680,GO:0021766,GO:0021794,GO:0021854,GO:0021860,GO:0030901" "mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex III|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|integral component of membrane|subthalamus development|pons development|cerebellar Purkinje cell layer development|hippocampus development|thalamus development|hypothalamus development|pyramidal neuron development|midbrain development" "hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022" Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases URB1 1330.672191 1411.841639 1249.502743 0.885016215 -0.176224207 0.464161423 1 6.965002164 6.060991317 9875 URB1 ribosome biogenesis homolog "GO:0000463,GO:0000466,GO:0001650,GO:0003723,GO:0005730,GO:0008150" "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|fibrillar center|RNA binding|nucleolus|biological_process" URB2 284.3764025 312.1241648 256.6286403 0.822200487 -0.282437869 0.381552631 1 2.957651459 2.391089883 9816 URB2 ribosome biogenesis homolog "GO:0005730,GO:0016235,GO:0030496,GO:0042254" nucleolus|aggresome|midbody|ribosome biogenesis URGCP 972.391804 938.4533221 1006.330286 1.072328545 0.100746994 0.685481109 1 11.67992747 12.31513542 55665 upregulator of cell proliferation "GO:0005525,GO:0005634,GO:0005829,GO:0007049" GTP binding|nucleus|cytosol|cell cycle URI1 1129.803114 983.1911191 1276.41511 1.298237021 0.376553802 0.121721781 1 12.47529791 15.92487725 8725 URI1 prefoldin like chaperone "GO:0000122,GO:0000993,GO:0001558,GO:0003682,GO:0003714,GO:0004864,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006357,GO:0009615,GO:0010923,GO:0019212,GO:0030425,GO:0032515,GO:0051219,GO:0071363,GO:0071383,GO:2001243" negative regulation of transcription by RNA polymerase II|RNA polymerase II complex binding|regulation of cell growth|chromatin binding|transcription corepressor activity|protein phosphatase inhibitor activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|regulation of transcription by RNA polymerase II|response to virus|negative regulation of phosphatase activity|phosphatase inhibitor activity|dendrite|negative regulation of phosphoprotein phosphatase activity|phosphoprotein binding|cellular response to growth factor stimulus|cellular response to steroid hormone stimulus|negative regulation of intrinsic apoptotic signaling pathway URM1 915.7873983 979.0294636 852.545333 0.870806615 -0.199575728 0.421815464 1 19.71660494 16.88204418 81605 ubiquitin related modifier 1 "GO:0002098,GO:0005515,GO:0005634,GO:0005829,GO:0006400,GO:0031386,GO:0032447,GO:0034227,GO:0097163" tRNA wobble uridine modification|protein binding|nucleus|cytosol|tRNA modification|protein tag|protein urmylation|tRNA thio-modification|sulfur carrier activity hsa04122 Sulfur relay system UROD 2269.216559 2168.222531 2370.210587 1.09315836 0.128502412 0.587513586 1 96.99417559 104.2557256 7389 uroporphyrinogen decarboxylase "GO:0004853,GO:0005515,GO:0005654,GO:0005829,GO:0006782,GO:0006783" uroporphyrinogen decarboxylase activity|protein binding|nucleoplasm|cytosol|protoporphyrinogen IX biosynthetic process|heme biosynthetic process hsa00860 Porphyrin and chlorophyll metabolism UROS 496.2855243 475.4691444 517.1019043 1.087561434 0.121096898 0.663078897 1 4.338333794 4.639251758 7390 uroporphyrinogen III synthase "GO:0004852,GO:0005739,GO:0005829,GO:0006780,GO:0006782,GO:0006783" uroporphyrinogen-III synthase activity|mitochondrion|cytosol|uroporphyrinogen III biosynthetic process|protoporphyrinogen IX biosynthetic process|heme biosynthetic process hsa00860 Porphyrin and chlorophyll metabolism USB1 1838.178971 1967.422652 1708.93529 0.868616252 -0.203209149 0.391507353 1 21.56010903 18.41408239 79650 U6 snRNA biogenesis phosphodiesterase 1 "GO:0000175,GO:0005634,GO:0005654,GO:0008380,GO:0034477,GO:0045171,GO:0090503,GO:1990838" "3'-5'-exoribonuclease activity|nucleus|nucleoplasm|RNA splicing|U6 snRNA 3'-end processing|intercellular bridge|RNA phosphodiester bond hydrolysis, exonucleolytic|poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends" USE1 119.8564165 118.6071826 121.1056505 1.021065064 0.030074799 0.966524276 1 7.394681479 7.424104343 55850 unconventional SNARE in the ER 1 "GO:0005484,GO:0005515,GO:0005764,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0006888,GO:0006890,GO:0007041,GO:0015031,GO:0016021,GO:0030137,GO:0030163,GO:0031201,GO:0032940,GO:0061025" "SNAP receptor activity|protein binding|lysosome|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|lysosomal transport|protein transport|integral component of membrane|COPI-coated vesicle|protein catabolic process|SNARE complex|secretion by cell|membrane fusion" hsa04130 SNARE interactions in vesicular transport USF1 753.4721574 780.310412 726.6339027 0.931211338 -0.102819471 0.688614637 1 22.15092156 20.28202123 7391 upstream transcription factor 1 "GO:0000430,GO:0000432,GO:0000785,GO:0000978,GO:0000981,GO:0001666,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006006,GO:0006357,GO:0009411,GO:0019086,GO:0019899,GO:0019901,GO:0032869,GO:0042593,GO:0042802,GO:0042803,GO:0042826,GO:0043425,GO:0043565,GO:0044877,GO:0045944,GO:0045990,GO:0046982,GO:0051918,GO:0055088,GO:1990837" "regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter by glucose|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|response to hypoxia|protein binding|nucleus|nucleoplasm|transcription regulator complex|glucose metabolic process|regulation of transcription by RNA polymerase II|response to UV|late viral transcription|enzyme binding|protein kinase binding|cellular response to insulin stimulus|glucose homeostasis|identical protein binding|protein homodimerization activity|histone deacetylase binding|bHLH transcription factor binding|sequence-specific DNA binding|protein-containing complex binding|positive regulation of transcription by RNA polymerase II|carbon catabolite regulation of transcription|protein heterodimerization activity|negative regulation of fibrinolysis|lipid homeostasis|sequence-specific double-stranded DNA binding" bHLH USF2 781.2274076 676.2690237 886.1857914 1.310404233 0.390011923 0.12229247 1 8.315952734 10.71490878 7392 "upstream transcription factor 2, c-fos interacting" "GO:0000430,GO:0000432,GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0019086,GO:0042803,GO:0043231,GO:0043425,GO:0043565,GO:0045944,GO:0046982,GO:0055088,GO:1990837" "regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter by glucose|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|late viral transcription|protein homodimerization activity|intracellular membrane-bounded organelle|bHLH transcription factor binding|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|lipid homeostasis|sequence-specific double-stranded DNA binding" bHLH USF3 330.9031476 335.0132702 326.793025 0.975462927 -0.035841052 0.916828978 1 1.304658677 1.251350161 205717 upstream transcription factor family member 3 "GO:0003677,GO:0005634,GO:0010719,GO:0046983" DNA binding|nucleus|negative regulation of epithelial to mesenchymal transition|protein dimerization activity USH2A 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.008228361 0.007474329 7399 usherin "GO:0001917,GO:0002141,GO:0002142,GO:0005515,GO:0005518,GO:0005604,GO:0005737,GO:0007601,GO:0007605,GO:0009887,GO:0009888,GO:0016021,GO:0016324,GO:0016477,GO:0017022,GO:0032391,GO:0032421,GO:0034446,GO:0035315,GO:0036064,GO:0042802,GO:0043025,GO:0043195,GO:0045184,GO:0045494,GO:0048496,GO:0050896,GO:0050953,GO:0060113,GO:0060171,GO:1990075,GO:1990696" photoreceptor inner segment|stereocilia ankle link|stereocilia ankle link complex|protein binding|collagen binding|basement membrane|cytoplasm|visual perception|sensory perception of sound|animal organ morphogenesis|tissue development|integral component of membrane|apical plasma membrane|cell migration|myosin binding|photoreceptor connecting cilium|stereocilium bundle|substrate adhesion-dependent cell spreading|hair cell differentiation|ciliary basal body|identical protein binding|neuronal cell body|terminal bouton|establishment of protein localization|photoreceptor cell maintenance|maintenance of animal organ identity|response to stimulus|sensory perception of light stimulus|inner ear receptor cell differentiation|stereocilium membrane|periciliary membrane compartment|USH2 complex USO1 2356.269756 2296.193439 2416.346073 1.052326878 0.07358291 0.756872877 1 29.10083676 30.11114835 8615 USO1 vesicle transport factor "GO:0000139,GO:0001650,GO:0003723,GO:0005515,GO:0005783,GO:0005794,GO:0005795,GO:0005829,GO:0006886,GO:0006888,GO:0007030,GO:0007264,GO:0012507,GO:0016020,GO:0030133,GO:0032252,GO:0045056,GO:0045296,GO:0048208,GO:0048211,GO:0048280,GO:0048471,GO:0061025,GO:1900076" Golgi membrane|fibrillar center|RNA binding|protein binding|endoplasmic reticulum|Golgi apparatus|Golgi stack|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|small GTPase mediated signal transduction|ER to Golgi transport vesicle membrane|membrane|transport vesicle|secretory granule localization|transcytosis|cadherin binding|COPII vesicle coating|Golgi vesicle docking|vesicle fusion with Golgi apparatus|perinuclear region of cytoplasm|membrane fusion|regulation of cellular response to insulin stimulus USP1 2458.587592 2408.558138 2508.617045 1.041543073 0.058722503 0.805201754 1 34.97695812 35.8204016 7398 ubiquitin specific peptidase 1 "GO:0001501,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006282,GO:0006511,GO:0008233,GO:0009411,GO:0016579,GO:0018215,GO:0035520,GO:0036297,GO:0042769" "skeletal system development|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of DNA repair|ubiquitin-dependent protein catabolic process|peptidase activity|response to UV|protein deubiquitination|protein phosphopantetheinylation|monoubiquitinated protein deubiquitination|interstrand cross-link repair|DNA damage response, detection of DNA damage" hsa03460 Fanconi anemia pathway USP10 4536.02397 4550.770323 4521.277617 0.993519184 -0.00938027 0.96971161 1 51.11897457 49.93781881 9100 ubiquitin specific peptidase 10 "GO:0002039,GO:0003723,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005769,GO:0005829,GO:0006511,GO:0006914,GO:0006974,GO:0010506,GO:0016579,GO:0018215,GO:0019985,GO:0030330,GO:0032991,GO:0043124,GO:0044325,GO:0045111,GO:0071347" "p53 binding|RNA binding|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytoplasm|early endosome|cytosol|ubiquitin-dependent protein catabolic process|autophagy|cellular response to DNA damage stimulus|regulation of autophagy|protein deubiquitination|protein phosphopantetheinylation|translesion synthesis|DNA damage response, signal transduction by p53 class mediator|protein-containing complex|negative regulation of I-kappaB kinase/NF-kappaB signaling|ion channel binding|intermediate filament cytoskeleton|cellular response to interleukin-1" USP11 2124.414133 2139.090943 2109.737323 0.986277526 -0.019934435 0.934892501 1 35.71944685 34.63977326 8237 ubiquitin specific peptidase 11 "GO:0001226,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006511,GO:0016032,GO:0016579,GO:0018215" RNA polymerase II transcription corepressor binding|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|chromosome|cytosol|ubiquitin-dependent protein catabolic process|viral process|protein deubiquitination|protein phosphopantetheinylation USP12 1410.592174 1352.538047 1468.646301 1.085844722 0.11881781 0.621285689 1 16.05124966 17.13751127 219333 ubiquitin specific peptidase 12 "GO:0004197,GO:0004843,GO:0005515,GO:0005575,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0016579,GO:0018215,GO:0046872" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|cellular_component|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein deubiquitination|protein phosphopantetheinylation|metal ion binding USP13 607.7387575 676.2690237 539.2084913 0.797328389 -0.326754057 0.213018639 1 10.26777663 8.049794963 8975 ubiquitin specific peptidase 13 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006511,GO:0006914,GO:0008270,GO:0008283,GO:0010506,GO:0016579,GO:0018215,GO:0030318,GO:0031625,GO:0035523,GO:0043130,GO:0044313,GO:0044389,GO:0050821,GO:0051087,GO:0070536,GO:0070628,GO:0071108,GO:1904288,GO:1904294,GO:1904378,GO:1990380" "cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|ubiquitin-dependent protein catabolic process|autophagy|zinc ion binding|cell population proliferation|regulation of autophagy|protein deubiquitination|protein phosphopantetheinylation|melanocyte differentiation|ubiquitin protein ligase binding|protein K29-linked deubiquitination|ubiquitin binding|protein K6-linked deubiquitination|ubiquitin-like protein ligase binding|protein stabilization|chaperone binding|protein K63-linked deubiquitination|proteasome binding|protein K48-linked deubiquitination|BAT3 complex binding|positive regulation of ERAD pathway|maintenance of unfolded protein involved in ERAD pathway|Lys48-specific deubiquitinase activity" USP14 3867.941822 3652.893142 4082.990501 1.117741566 0.16058666 0.4999663 1 39.20921023 43.09239923 9097 ubiquitin specific peptidase 14 "GO:0000502,GO:0004197,GO:0004843,GO:0004866,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0006511,GO:0009986,GO:0010951,GO:0016579,GO:0018215,GO:0031410,GO:0045087,GO:0050920,GO:0061136,GO:0070062,GO:0070628,GO:1903070" proteasome complex|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|endopeptidase inhibitor activity|protein binding|nucleus|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|cell surface|negative regulation of endopeptidase activity|protein deubiquitination|protein phosphopantetheinylation|cytoplasmic vesicle|innate immune response|regulation of chemotaxis|regulation of proteasomal protein catabolic process|extracellular exosome|proteasome binding|negative regulation of ER-associated ubiquitin-dependent protein catabolic process USP15 1382.733128 1416.003294 1349.462962 0.953008349 -0.069439241 0.774416961 1 4.082410097 3.825467473 9958 ubiquitin specific peptidase 15 "GO:0004197,GO:0004843,GO:0005160,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006511,GO:0007179,GO:0016032,GO:0016579,GO:0018215,GO:0030509,GO:0035520,GO:0035616,GO:0042802,GO:0046332,GO:0060389,GO:0061649,GO:0071108,GO:1900246,GO:1990380" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|transforming growth factor beta receptor binding|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|transforming growth factor beta receptor signaling pathway|viral process|protein deubiquitination|protein phosphopantetheinylation|BMP signaling pathway|monoubiquitinated protein deubiquitination|histone H2B conserved C-terminal lysine deubiquitination|identical protein binding|SMAD binding|pathway-restricted SMAD protein phosphorylation|ubiquitin modification-dependent histone binding|protein K48-linked deubiquitination|positive regulation of RIG-I signaling pathway|Lys48-specific deubiquitinase activity hsa04137 Mitophagy - animal USP16 807.1830344 764.7042037 849.6618651 1.111098724 0.15198701 0.5476514 1 12.56105198 13.72302455 10600 ubiquitin specific peptidase 16 "GO:0000278,GO:0003713,GO:0004197,GO:0004843,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006511,GO:0006974,GO:0008270,GO:0016578,GO:0016579,GO:0018215,GO:0035522,GO:0042393,GO:0043130,GO:0045893,GO:0045901,GO:0045944,GO:0051289,GO:0051301,GO:0051726,GO:0070537,GO:0140014" "mitotic cell cycle|transcription coactivator activity|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|zinc ion binding|histone deubiquitination|protein deubiquitination|protein phosphopantetheinylation|monoubiquitinated histone H2A deubiquitination|histone binding|ubiquitin binding|positive regulation of transcription, DNA-templated|positive regulation of translational elongation|positive regulation of transcription by RNA polymerase II|protein homotetramerization|cell division|regulation of cell cycle|histone H2A K63-linked deubiquitination|mitotic nuclear division" USP18 104.7207254 112.3646993 97.07675156 0.863943499 -0.210991129 0.659812334 1 2.759639892 2.34427704 11274 ubiquitin specific peptidase 18 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005829,GO:0006511,GO:0016579,GO:0018215,GO:0043231,GO:0050727,GO:0060338" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytosol|ubiquitin-dependent protein catabolic process|protein deubiquitination|protein phosphopantetheinylation|intracellular membrane-bounded organelle|regulation of inflammatory response|regulation of type I interferon-mediated signaling pathway USP19 1286.974808 1324.446873 1249.502743 0.943414771 -0.084035906 0.729434421 1 13.37179254 12.4040492 10869 ubiquitin specific peptidase 19 "GO:0004843,GO:0005515,GO:0005789,GO:0005829,GO:0008234,GO:0016021,GO:0016579,GO:0018215,GO:0030433,GO:0031625,GO:0031647,GO:0034976,GO:0046872,GO:0048642,GO:0050821,GO:0051879,GO:0071108,GO:0090068,GO:1900037,GO:1901799,GO:1904292,GO:1990380" thiol-dependent ubiquitin-specific protease activity|protein binding|endoplasmic reticulum membrane|cytosol|cysteine-type peptidase activity|integral component of membrane|protein deubiquitination|protein phosphopantetheinylation|ubiquitin-dependent ERAD pathway|ubiquitin protein ligase binding|regulation of protein stability|response to endoplasmic reticulum stress|metal ion binding|negative regulation of skeletal muscle tissue development|protein stabilization|Hsp90 protein binding|protein K48-linked deubiquitination|positive regulation of cell cycle process|regulation of cellular response to hypoxia|negative regulation of proteasomal protein catabolic process|regulation of ERAD pathway|Lys48-specific deubiquitinase activity USP2 8.367970443 5.202069413 11.53387147 2.217169852 1.148719296 0.387101353 1 0.064850475 0.141378479 9099 ubiquitin specific peptidase 2 "GO:0000122,GO:0004197,GO:0004843,GO:0005515,GO:0005654,GO:0005737,GO:0005813,GO:0006511,GO:0007049,GO:0007517,GO:0016020,GO:0016579,GO:0018215,GO:0030332,GO:0031625,GO:0032922,GO:0042802,GO:0043153,GO:0045475,GO:0045931,GO:0046872,GO:0048471,GO:0048512,GO:0050821" negative regulation of transcription by RNA polymerase II|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleoplasm|cytoplasm|centrosome|ubiquitin-dependent protein catabolic process|cell cycle|muscle organ development|membrane|protein deubiquitination|protein phosphopantetheinylation|cyclin binding|ubiquitin protein ligase binding|circadian regulation of gene expression|identical protein binding|entrainment of circadian clock by photoperiod|locomotor rhythm|positive regulation of mitotic cell cycle|metal ion binding|perinuclear region of cytoplasm|circadian behavior|protein stabilization USP20 626.9769679 638.8141239 615.1398118 0.962940218 -0.05448186 0.840177574 1 6.321590155 5.985450456 10868 ubiquitin specific peptidase 20 "GO:0001664,GO:0004197,GO:0004843,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0006511,GO:0006897,GO:0008270,GO:0008277,GO:0016579,GO:0018215,GO:0048471,GO:0070536,GO:0071108" G protein-coupled receptor binding|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|cytoplasm|centrosome|cytosol|ubiquitin-dependent protein catabolic process|endocytosis|zinc ion binding|regulation of G protein-coupled receptor signaling pathway|protein deubiquitination|protein phosphopantetheinylation|perinuclear region of cytoplasm|protein K63-linked deubiquitination|protein K48-linked deubiquitination USP21 758.0055648 760.5425482 755.4685814 0.993328491 -0.009657204 0.975414101 1 16.02398657 15.65073157 27005 ubiquitin specific peptidase 21 "GO:0003713,GO:0004843,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006511,GO:0008234,GO:0016578,GO:0016579,GO:0018215,GO:0019784,GO:0031175,GO:0045893,GO:0046872" "transcription coactivator activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|cysteine-type peptidase activity|histone deubiquitination|protein deubiquitination|protein phosphopantetheinylation|NEDD8-specific protease activity|neuron projection development|positive regulation of transcription, DNA-templated|metal ion binding" hsa04217 Necroptosis USP22 4956.695205 5034.562778 4878.827633 0.969066798 -0.04533198 0.850857661 1 50.90666206 48.50645254 23326 ubiquitin specific peptidase 22 "GO:0000124,GO:0003713,GO:0004843,GO:0005515,GO:0005654,GO:0006511,GO:0007049,GO:0008234,GO:0008270,GO:0009792,GO:0010485,GO:0016574,GO:0016578,GO:0016579,GO:0018215,GO:0019899,GO:0030374,GO:0043967,GO:0045893,GO:0045931,GO:0070461" "SAGA complex|transcription coactivator activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleoplasm|ubiquitin-dependent protein catabolic process|cell cycle|cysteine-type peptidase activity|zinc ion binding|embryo development ending in birth or egg hatching|H4 histone acetyltransferase activity|histone ubiquitination|histone deubiquitination|protein deubiquitination|protein phosphopantetheinylation|enzyme binding|nuclear receptor coactivator activity|histone H4 acetylation|positive regulation of transcription, DNA-templated|positive regulation of mitotic cell cycle|SAGA-type complex" USP24 2658.297367 2832.006589 2484.588146 0.877324282 -0.188817896 0.424816401 1 13.45011895 11.60265699 23358 ubiquitin specific peptidase 24 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0016032,GO:0016579,GO:0018215" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|viral process|protein deubiquitination|protein phosphopantetheinylation USP25 2045.462179 1883.149128 2207.775231 1.172384703 0.229446049 0.332300866 1 15.92713278 18.36026404 29761 ubiquitin specific peptidase 25 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005783,GO:0005829,GO:0006464,GO:0006508,GO:0006511,GO:0008233,GO:0016579,GO:0018215,GO:0019783,GO:0031625,GO:0032183,GO:0043130,GO:0051117,GO:0070536,GO:0071108,GO:1904293" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|endoplasmic reticulum|cytosol|cellular protein modification process|proteolysis|ubiquitin-dependent protein catabolic process|peptidase activity|protein deubiquitination|protein phosphopantetheinylation|ubiquitin-like protein-specific protease activity|ubiquitin protein ligase binding|SUMO binding|ubiquitin binding|ATPase binding|protein K63-linked deubiquitination|protein K48-linked deubiquitination|negative regulation of ERAD pathway hsa04657 IL-17 signaling pathway USP27X 166.36304 191.4361544 141.2899255 0.738052464 -0.438204721 0.262400992 1 3.322470152 2.411123752 389856 ubiquitin specific peptidase 27 X-linked "GO:0004843,GO:0005634,GO:0005829,GO:0006511,GO:0008234,GO:0016579,GO:0018215,GO:0043065,GO:0050821,GO:0061578,GO:0070536,GO:0071108,GO:1990380" thiol-dependent ubiquitin-specific protease activity|nucleus|cytosol|ubiquitin-dependent protein catabolic process|cysteine-type peptidase activity|protein deubiquitination|protein phosphopantetheinylation|positive regulation of apoptotic process|protein stabilization|Lys63-specific deubiquitinase activity|protein K63-linked deubiquitination|protein K48-linked deubiquitination|Lys48-specific deubiquitinase activity USP28 1292.815357 1439.932814 1145.6979 0.795660665 -0.329774817 0.170720699 1 14.16265532 11.08010185 57646 ubiquitin specific peptidase 28 "GO:0000077,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006511,GO:0006974,GO:0007265,GO:0008283,GO:0010212,GO:0016579,GO:0016604,GO:0018215,GO:0031647,GO:0032991,GO:0034644,GO:0042771" DNA damage checkpoint|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytosol|DNA repair|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|Ras protein signal transduction|cell population proliferation|response to ionizing radiation|protein deubiquitination|nuclear body|protein phosphopantetheinylation|regulation of protein stability|protein-containing complex|cellular response to UV|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator USP3 708.9224444 721.0068207 696.8380681 0.966479162 -0.049189467 0.852635572 1 5.201244778 4.942776421 9960 ubiquitin specific peptidase 3 "GO:0000122,GO:0000278,GO:0000785,GO:0000978,GO:0004843,GO:0005634,GO:0005654,GO:0005737,GO:0006281,GO:0006511,GO:0008234,GO:0008270,GO:0016578,GO:0016579,GO:0018215,GO:0031647,GO:0036464,GO:0042393,GO:0090543,GO:1990841" negative regulation of transcription by RNA polymerase II|mitotic cell cycle|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|thiol-dependent ubiquitin-specific protease activity|nucleus|nucleoplasm|cytoplasm|DNA repair|ubiquitin-dependent protein catabolic process|cysteine-type peptidase activity|zinc ion binding|histone deubiquitination|protein deubiquitination|protein phosphopantetheinylation|regulation of protein stability|cytoplasmic ribonucleoprotein granule|histone binding|Flemming body|promoter-specific chromatin binding USP30 408.0428443 417.2059669 398.8797217 0.956073866 -0.06480601 0.82947092 1 4.76064051 4.475360387 84749 ubiquitin specific peptidase 30 "GO:0000422,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005739,GO:0005741,GO:0005829,GO:0006511,GO:0008053,GO:0016021,GO:0016579,GO:0018215,GO:0035871,GO:0044313,GO:1901525" autophagy of mitochondrion|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|mitochondrion|mitochondrial outer membrane|cytosol|ubiquitin-dependent protein catabolic process|mitochondrial fusion|integral component of membrane|protein deubiquitination|protein phosphopantetheinylation|protein K11-linked deubiquitination|protein K6-linked deubiquitination|negative regulation of mitophagy hsa04137 Mitophagy - animal USP31 738.0741548 729.3301317 746.8181778 1.023978231 0.034185044 0.898445023 1 2.970768484 2.991098468 57478 ubiquitin specific peptidase 31 "GO:0004843,GO:0005634,GO:0006511,GO:0008234,GO:0016579,GO:0018215" thiol-dependent ubiquitin-specific protease activity|nucleus|ubiquitin-dependent protein catabolic process|cysteine-type peptidase activity|protein deubiquitination|protein phosphopantetheinylation USP32 2313.185086 2477.225455 2149.144718 0.867561212 -0.204962542 0.386099814 1 17.59682811 15.01086424 84669 ubiquitin specific peptidase 32 "GO:0004843,GO:0005509,GO:0005515,GO:0005794,GO:0005829,GO:0006511,GO:0008234,GO:0016020,GO:0016579,GO:0018215" thiol-dependent ubiquitin-specific protease activity|calcium ion binding|protein binding|Golgi apparatus|cytosol|ubiquitin-dependent protein catabolic process|cysteine-type peptidase activity|membrane|protein deubiquitination|protein phosphopantetheinylation USP33 2088.133625 2031.928313 2144.338938 1.055322141 0.077683454 0.744006611 1 21.84974401 22.67266555 23032 ubiquitin specific peptidase 33 "GO:0001664,GO:0004197,GO:0004843,GO:0005515,GO:0005654,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0005925,GO:0006511,GO:0006897,GO:0007411,GO:0008270,GO:0008277,GO:0009267,GO:0010506,GO:0016477,GO:0016579,GO:0018215,GO:0030891,GO:0031267,GO:0032091,GO:0032092,GO:0043130,GO:0044297,GO:0048471,GO:0050821,GO:0051298,GO:0070536,GO:0071108" G protein-coupled receptor binding|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleoplasm|cytoplasm|Golgi apparatus|centrosome|cytosol|focal adhesion|ubiquitin-dependent protein catabolic process|endocytosis|axon guidance|zinc ion binding|regulation of G protein-coupled receptor signaling pathway|cellular response to starvation|regulation of autophagy|cell migration|protein deubiquitination|protein phosphopantetheinylation|VCB complex|small GTPase binding|negative regulation of protein binding|positive regulation of protein binding|ubiquitin binding|cell body|perinuclear region of cytoplasm|protein stabilization|centrosome duplication|protein K63-linked deubiquitination|protein K48-linked deubiquitination USP34 2898.539854 3146.211581 2650.868127 0.842558759 -0.247150793 0.296339763 1 14.38180125 11.91474246 9736 ubiquitin specific peptidase 34 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005829,GO:0006511,GO:0016055,GO:0016579,GO:0018215,GO:0071108,GO:0090263" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytosol|ubiquitin-dependent protein catabolic process|Wnt signaling pathway|protein deubiquitination|protein phosphopantetheinylation|protein K48-linked deubiquitination|positive regulation of canonical Wnt signaling pathway USP35 535.0978697 560.7830827 509.4126567 0.908395193 -0.138608023 0.610431252 1 6.899023156 6.162169053 57558 ubiquitin specific peptidase 35 "GO:0004197,GO:0004843,GO:0005634,GO:0005829,GO:0006511,GO:0016579,GO:0018215" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|nucleus|cytosol|ubiquitin-dependent protein catabolic process|protein deubiquitination|protein phosphopantetheinylation USP36 1560.094741 1643.853935 1476.335548 0.898094117 -0.155061452 0.51601561 1 12.23392319 10.8033583 57602 ubiquitin specific peptidase 36 "GO:0003723,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006511,GO:0007000,GO:0016242,GO:0016578,GO:0016579,GO:0016607,GO:0018215,GO:0031647,GO:0042981,GO:0050821,GO:1903146,GO:1903955,GO:2000232" RNA binding|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|nucleolus organization|negative regulation of macroautophagy|histone deubiquitination|protein deubiquitination|nuclear speck|protein phosphopantetheinylation|regulation of protein stability|regulation of apoptotic process|protein stabilization|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion|regulation of rRNA processing USP37 541.0132605 589.9146715 492.1118495 0.834208528 -0.261520035 0.331070256 1 3.865749239 3.170877634 57695 ubiquitin specific peptidase 37 "GO:0000082,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006275,GO:0006511,GO:0016579,GO:0018215,GO:0019901,GO:0035871,GO:0051301,GO:0071108" G1/S transition of mitotic cell cycle|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of DNA replication|ubiquitin-dependent protein catabolic process|protein deubiquitination|protein phosphopantetheinylation|protein kinase binding|protein K11-linked deubiquitination|cell division|protein K48-linked deubiquitination USP38 614.6851157 631.5312268 597.8390046 0.946649951 -0.079097046 0.767540836 1 4.31048227 4.012235888 84640 ubiquitin specific peptidase 38 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005829,GO:0006511,GO:0016579,GO:0018215" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytosol|ubiquitin-dependent protein catabolic process|protein deubiquitination|protein phosphopantetheinylation USP39 1947.107854 1773.90567 2120.310039 1.195277784 0.257345942 0.277122692 1 34.48819137 40.53315841 10713 ubiquitin specific peptidase 39 "GO:0000245,GO:0000398,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0006397,GO:0007049,GO:0008270,GO:0008380,GO:0016579,GO:0018215,GO:0046540,GO:0051301" "spliceosomal complex assembly|mRNA splicing, via spliceosome|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|spliceosomal complex|mRNA processing|cell cycle|zinc ion binding|RNA splicing|protein deubiquitination|protein phosphopantetheinylation|U4/U6 x U5 tri-snRNP complex|cell division" hsa03040 Spliceosome USP4 1300.659933 1153.818996 1447.50087 1.254530282 0.327147295 0.174094488 1 12.56934051 15.50475182 7375 ubiquitin specific peptidase 4 "GO:0000244,GO:0004843,GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005829,GO:0005886,GO:0006511,GO:0008234,GO:0016579,GO:0018215,GO:0031397,GO:0031647,GO:0031685,GO:0034394,GO:0042802,GO:0046872" spliceosomal tri-snRNP complex assembly|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytoplasm|lysosome|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|cysteine-type peptidase activity|protein deubiquitination|protein phosphopantetheinylation|negative regulation of protein ubiquitination|regulation of protein stability|adenosine receptor binding|protein localization to cell surface|identical protein binding|metal ion binding USP40 1034.217172 1060.181746 1008.252598 0.951018635 -0.072454484 0.770646734 1 6.216210863 5.812807538 55230 ubiquitin specific peptidase 40 "GO:0004197,GO:0004843,GO:0005634,GO:0005829,GO:0006511,GO:0016579,GO:0018215,GO:0031647" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|nucleus|cytosol|ubiquitin-dependent protein catabolic process|protein deubiquitination|protein phosphopantetheinylation|regulation of protein stability USP42 398.8822946 391.1956199 406.5689694 1.039298368 0.055609892 0.855902981 1 3.203527888 3.27370795 84132 ubiquitin specific peptidase 42 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0007283,GO:0016579,GO:0018215,GO:0030154,GO:0042981" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|spermatogenesis|protein deubiquitination|protein phosphopantetheinylation|cell differentiation|regulation of apoptotic process USP43 226.340938 226.8102264 225.8716497 0.995861841 -0.005982488 1 1 1.865666604 1.826855966 124739 ubiquitin specific peptidase 43 "GO:0004843,GO:0005654,GO:0006511,GO:0016579,GO:0018215,GO:0019785,GO:0019985" thiol-dependent ubiquitin-specific protease activity|nucleoplasm|ubiquitin-dependent protein catabolic process|protein deubiquitination|protein phosphopantetheinylation|ISG15-specific protease activity|translesion synthesis USP45 452.3598139 457.7821084 446.9375195 0.976310588 -0.034587917 0.90979536 1 1.990466821 1.910795107 85015 ubiquitin specific peptidase 45 "GO:0001917,GO:0003407,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006281,GO:0006511,GO:0008234,GO:0008270,GO:0016477,GO:0016579,GO:0018215,GO:0045494,GO:0070911" photoreceptor inner segment|neural retina development|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytoplasm|DNA repair|ubiquitin-dependent protein catabolic process|cysteine-type peptidase activity|zinc ion binding|cell migration|protein deubiquitination|protein phosphopantetheinylation|photoreceptor cell maintenance|global genome nucleotide-excision repair USP46 574.2077395 603.4400519 544.975427 0.903114444 -0.147019275 0.582690941 1 3.861912279 3.429386009 64854 ubiquitin specific peptidase 46 "GO:0001662,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005829,GO:0006511,GO:0008343,GO:0016579,GO:0018215,GO:0032228,GO:0046872,GO:0048149,GO:0060013,GO:0098978,GO:0099149" "behavioral fear response|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytosol|ubiquitin-dependent protein catabolic process|adult feeding behavior|protein deubiquitination|protein phosphopantetheinylation|regulation of synaptic transmission, GABAergic|metal ion binding|behavioral response to ethanol|righting reflex|glutamatergic synapse|regulation of postsynaptic neurotransmitter receptor internalization" USP47 1662.298721 1740.612426 1583.985015 0.910015919 -0.136036313 0.568083187 1 10.99068694 9.834335169 55031 ubiquitin specific peptidase 47 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006284,GO:0006511,GO:0006974,GO:0010972,GO:0016579,GO:0018215,GO:0019005,GO:0030307,GO:0031647,GO:0034644,GO:0035520,GO:0042493,GO:0043066,GO:0043154,GO:0045892,GO:0071987,GO:0090263,GO:0101005,GO:1902230" "cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|base-excision repair|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|protein phosphopantetheinylation|SCF ubiquitin ligase complex|positive regulation of cell growth|regulation of protein stability|cellular response to UV|monoubiquitinated protein deubiquitination|response to drug|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of transcription, DNA-templated|WD40-repeat domain binding|positive regulation of canonical Wnt signaling pathway|ubiquitinyl hydrolase activity|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage" USP48 1581.805653 1532.529649 1631.081657 1.064306755 0.089914025 0.707474254 1 15.19945934 15.90618894 84196 ubiquitin specific peptidase 48 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006511,GO:0016579,GO:0018215" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|ubiquitin-dependent protein catabolic process|protein deubiquitination|protein phosphopantetheinylation USP49 397.019119 443.216314 350.8219239 0.791536577 -0.337272076 0.244919605 1 2.358759482 1.835801946 25862 ubiquitin specific peptidase 49 "GO:0000398,GO:0004197,GO:0004843,GO:0005515,GO:0005654,GO:0005737,GO:0006511,GO:0008270,GO:0016579,GO:0018215,GO:0035616,GO:0042393" "mRNA splicing, via spliceosome|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleoplasm|cytoplasm|ubiquitin-dependent protein catabolic process|zinc ion binding|protein deubiquitination|protein phosphopantetheinylation|histone H2B conserved C-terminal lysine deubiquitination|histone binding" USP5 2226.411135 2053.777004 2399.045266 1.168113803 0.224180834 0.343184875 1 34.91758651 40.10518758 8078 ubiquitin specific peptidase 5 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005764,GO:0005829,GO:0006511,GO:0008270,GO:0016567,GO:0016579,GO:0018215,GO:0032436,GO:0043130,GO:0071108" cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|lysosome|cytosol|ubiquitin-dependent protein catabolic process|zinc ion binding|protein ubiquitination|protein deubiquitination|protein phosphopantetheinylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|ubiquitin binding|protein K48-linked deubiquitination USP51 15.57160969 17.687036 13.45618338 0.760793577 -0.394423029 0.724394511 1 0.199350497 0.149126676 158880 ubiquitin specific peptidase 51 "GO:0003682,GO:0004843,GO:0005694,GO:0006281,GO:0006511,GO:0008234,GO:0008270,GO:0010564,GO:0010569,GO:0016578,GO:0016579,GO:0018215,GO:0042393,GO:2001020,GO:2001032" chromatin binding|thiol-dependent ubiquitin-specific protease activity|chromosome|DNA repair|ubiquitin-dependent protein catabolic process|cysteine-type peptidase activity|zinc ion binding|regulation of cell cycle process|regulation of double-strand break repair via homologous recombination|histone deubiquitination|protein deubiquitination|protein phosphopantetheinylation|histone binding|regulation of response to DNA damage stimulus|regulation of double-strand break repair via nonhomologous end joining USP53 1480.389837 1368.144256 1592.635419 1.164084425 0.219195693 0.35911119 1 9.98159185 11.42498042 54532 ubiquitin specific peptidase 53 "GO:0001508,GO:0004843,GO:0005515,GO:0005575,GO:0005911,GO:0005923,GO:0007605,GO:0008150,GO:0010996,GO:0016579,GO:0018215,GO:0051402" action potential|thiol-dependent ubiquitin-specific protease activity|protein binding|cellular_component|cell-cell junction|bicellular tight junction|sensory perception of sound|biological_process|response to auditory stimulus|protein deubiquitination|protein phosphopantetheinylation|neuron apoptotic process USP54 968.9523019 1125.727821 812.1767828 0.721468163 -0.470992363 0.056042543 1 6.200642461 4.398707054 159195 ubiquitin specific peptidase 54 "GO:0004843,GO:0005515,GO:0016579,GO:0018215" thiol-dependent ubiquitin-specific protease activity|protein binding|protein deubiquitination|protein phosphopantetheinylation USP6NL 566.3549456 611.763363 520.9465281 0.851549079 -0.231838413 0.384764221 1 3.717259058 3.112459367 9712 USP6 N-terminal like "GO:0005096,GO:0005829,GO:0005886,GO:0006886,GO:0007030,GO:0019068,GO:0031267,GO:0031410,GO:0032588,GO:0035526,GO:0043547,GO:0048227,GO:0090630,GO:1902017,GO:1903358" "GTPase activator activity|cytosol|plasma membrane|intracellular protein transport|Golgi organization|virion assembly|small GTPase binding|cytoplasmic vesicle|trans-Golgi network membrane|retrograde transport, plasma membrane to Golgi|positive regulation of GTPase activity|plasma membrane to endosome transport|activation of GTPase activity|regulation of cilium assembly|regulation of Golgi organization" USP7 2336.961734 2407.517724 2266.405744 0.94138694 -0.087140256 0.713530343 1 19.57117991 18.1157516 7874 ubiquitin specific peptidase 7 "GO:0002039,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006111,GO:0006283,GO:0006511,GO:0007275,GO:0008022,GO:0008134,GO:0010216,GO:0016032,GO:0016567,GO:0016579,GO:0016604,GO:0016605,GO:0018215,GO:0031625,GO:0031647,GO:0032088,GO:0032435,GO:0032991,GO:0035520,GO:0035616,GO:0042752,GO:0048511,GO:0050821,GO:0051090,GO:0070536,GO:0071108,GO:0101005,GO:1901537,GO:1904353,GO:1905279,GO:1990380" "p53 binding|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|chromosome|cytosol|regulation of gluconeogenesis|transcription-coupled nucleotide-excision repair|ubiquitin-dependent protein catabolic process|multicellular organism development|protein C-terminus binding|transcription factor binding|maintenance of DNA methylation|viral process|protein ubiquitination|protein deubiquitination|nuclear body|PML body|protein phosphopantetheinylation|ubiquitin protein ligase binding|regulation of protein stability|negative regulation of NF-kappaB transcription factor activity|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein-containing complex|monoubiquitinated protein deubiquitination|histone H2B conserved C-terminal lysine deubiquitination|regulation of circadian rhythm|rhythmic process|protein stabilization|regulation of DNA-binding transcription factor activity|protein K63-linked deubiquitination|protein K48-linked deubiquitination|ubiquitinyl hydrolase activity|positive regulation of DNA demethylation|regulation of telomere capping|regulation of retrograde transport, endosome to Golgi|Lys48-specific deubiquitinase activity" "hsa04068,hsa05169,hsa05203" FoxO signaling pathway|Epstein-Barr virus infection|Viral carcinogenesis USP8 1153.716928 1169.425204 1138.008652 0.973135048 -0.039288065 0.874920444 1 13.25336034 12.68149044 9101 ubiquitin specific peptidase 8 "GO:0000281,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005737,GO:0005769,GO:0005829,GO:0006511,GO:0007032,GO:0007265,GO:0014069,GO:0016579,GO:0017124,GO:0018215,GO:0019897,GO:0030496,GO:0031313,GO:0031647,GO:0032880,GO:0043197,GO:0045296,GO:0070536,GO:0071108,GO:0071549,GO:0090263,GO:0098978,GO:0099576,GO:1990090" "mitotic cytokinesis|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytoplasm|early endosome|cytosol|ubiquitin-dependent protein catabolic process|endosome organization|Ras protein signal transduction|postsynaptic density|protein deubiquitination|SH3 domain binding|protein phosphopantetheinylation|extrinsic component of plasma membrane|midbody|extrinsic component of endosome membrane|regulation of protein stability|regulation of protein localization|dendritic spine|cadherin binding|protein K63-linked deubiquitination|protein K48-linked deubiquitination|cellular response to dexamethasone stimulus|positive regulation of canonical Wnt signaling pathway|glutamatergic synapse|regulation of protein catabolic process at postsynapse, modulating synaptic transmission|cellular response to nerve growth factor stimulus" "hsa04137,hsa04144,hsa04934" Mitophagy - animal|Endocytosis|Cushing syndrome USP9X 7300.703906 7147.643374 7453.764439 1.042828251 0.060501572 0.805419336 1 38.16092337 39.12936871 8239 ubiquitin specific peptidase 9 X-linked "GO:0000122,GO:0001764,GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006625,GO:0007049,GO:0007059,GO:0007179,GO:0007292,GO:0008234,GO:0016020,GO:0016477,GO:0016567,GO:0016579,GO:0018215,GO:0030426,GO:0030509,GO:0042752,GO:0044267,GO:0048511,GO:0048675,GO:0050821,GO:0051301,GO:0070410,GO:0071108,GO:0071947,GO:0101005,GO:1901537,GO:1990380" negative regulation of transcription by RNA polymerase II|neuron migration|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytoplasm|cytosol|protein targeting to peroxisome|cell cycle|chromosome segregation|transforming growth factor beta receptor signaling pathway|female gamete generation|cysteine-type peptidase activity|membrane|cell migration|protein ubiquitination|protein deubiquitination|protein phosphopantetheinylation|growth cone|BMP signaling pathway|regulation of circadian rhythm|cellular protein metabolic process|rhythmic process|axon extension|protein stabilization|cell division|co-SMAD binding|protein K48-linked deubiquitination|protein deubiquitination involved in ubiquitin-dependent protein catabolic process|ubiquitinyl hydrolase activity|positive regulation of DNA demethylation|Lys48-specific deubiquitinase activity USPL1 677.0608732 679.3902654 674.7314811 0.993142698 -0.009927071 0.975664338 1 7.058168152 6.892469184 10208 ubiquitin specific peptidase like 1 "GO:0005515,GO:0005615,GO:0008283,GO:0009301,GO:0015030,GO:0016926,GO:0030576,GO:0032183,GO:0043130,GO:0070140" protein binding|extracellular space|cell population proliferation|snRNA transcription|Cajal body|protein desumoylation|Cajal body organization|SUMO binding|ubiquitin binding|SUMO-specific isopeptidase activity UST 165.842833 190.3957405 141.2899255 0.742085538 -0.430342603 0.271773962 1 1.459504559 1.064953395 10090 uronyl 2-sulfotransferase "GO:0000139,GO:0006477,GO:0008146,GO:0016021,GO:0030010,GO:0030208,GO:0050770" Golgi membrane|protein sulfation|sulfotransferase activity|integral component of membrane|establishment of cell polarity|dermatan sulfate biosynthetic process|regulation of axonogenesis hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate UTP11 474.640008 424.4888641 524.791152 1.236289562 0.306016689 0.269563402 1 11.09955439 13.49263974 51118 UTP11 small subunit processome component "GO:0003723,GO:0005515,GO:0005615,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0007399,GO:0032040,GO:0043065" RNA binding|protein binding|extracellular space|nucleoplasm|nucleolus|cytoplasm|rRNA processing|nervous system development|small-subunit processome|positive regulation of apoptotic process UTP14A 966.0933718 1164.223135 767.9636088 0.659636101 -0.600257738 0.015008401 0.712638468 22.52808156 14.61166828 10813 UTP14A small subunit processome component "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0006364,GO:0032040" RNA binding|protein binding|nucleoplasm|nucleolus|cytosol|rRNA processing|small-subunit processome hsa03008 Ribosome biogenesis in eukaryotes UTP15 360.9612937 379.7510672 342.1715203 0.901041629 -0.150334333 0.618844526 1 3.781085168 3.34990503 84135 UTP15 small subunit processome component "GO:0001650,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005783,GO:0006364,GO:0045943,GO:2000234" fibrillar center|RNA binding|protein binding|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum|rRNA processing|positive regulation of transcription by RNA polymerase I|positive regulation of rRNA processing hsa03008 Ribosome biogenesis in eukaryotes UTP18 1098.906501 1130.92989 1066.883111 0.943368037 -0.084107374 0.732854146 1 21.23703367 19.69909125 51096 UTP18 small subunit processome component "GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0031965,GO:0032040,GO:0034388" RNA binding|nucleus|nucleoplasm|nucleolus|rRNA processing|nuclear membrane|small-subunit processome|Pwp2p-containing subcomplex of 90S preribosome hsa03008 Ribosome biogenesis in eukaryotes UTP20 1160.820573 1330.689356 990.9517906 0.744690552 -0.425287041 0.079746397 1 7.863630298 5.757979438 27340 UTP20 small subunit processome component "GO:0000447,GO:0000472,GO:0000480,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005886,GO:0006364,GO:0008285,GO:0030686,GO:0030688,GO:0032040" "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|protein binding|nucleoplasm|nucleolus|cytoplasm|plasma membrane|rRNA processing|negative regulation of cell population proliferation|90S preribosome|preribosome, small subunit precursor|small-subunit processome" UTP23 466.8463504 484.8328693 448.8598314 0.92580322 -0.111222515 0.694236498 1 7.046470357 6.414480581 84294 UTP23 small subunit processome component "GO:0000480,GO:0003723,GO:0003730,GO:0005515,GO:0005730,GO:0032040,GO:0048027,GO:0070181" "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|mRNA 3'-UTR binding|protein binding|nucleolus|small-subunit processome|mRNA 5'-UTR binding|small ribosomal subunit rRNA binding" UTP25 983.1865877 1083.070852 883.3023236 0.815553592 -0.294148412 0.232278123 1 6.787400277 5.44285977 27042 UTP25 small subunit processor component "GO:0000462,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0007275,GO:0019843,GO:0030163,GO:0031648,GO:0032040,GO:0034511,GO:0040019" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|protein binding|nucleoplasm|nucleolus|rRNA processing|multicellular organism development|rRNA binding|protein catabolic process|protein destabilization|small-subunit processome|U3 snoRNA binding|positive regulation of embryonic development" UTP3 768.2763399 714.7643374 821.7883424 1.149733275 0.201299211 0.427529919 1 18.88398961 21.34823781 57050 UTP3 small subunit processome component "GO:0000462,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006325,GO:0006364,GO:0007420,GO:0032040" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|chromatin organization|rRNA processing|brain development|small-subunit processome" UTP4 1476.381053 1477.387713 1475.374392 0.998637243 -0.001967384 0.996678404 1 33.6371446 33.02920033 84916 UTP4 small subunit processome component "GO:0000462,GO:0001650,GO:0003723,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0006355,GO:0006364,GO:0030490,GO:0030686,GO:0032040,GO:0034455" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|fibrillar center|RNA binding|protein binding|nucleoplasm|chromosome|nucleolus|regulation of transcription, DNA-templated|rRNA processing|maturation of SSU-rRNA|90S preribosome|small-subunit processome|t-UTP complex" hsa03008 Ribosome biogenesis in eukaryotes UTP6 1229.994848 1203.758862 1256.230834 1.043590103 0.061555167 0.801787698 1 14.72098947 15.10560529 55813 UTP6 small subunit processome component "GO:0000462,GO:0005515,GO:0005654,GO:0005694,GO:0005730,GO:0006364,GO:0030515,GO:0032040,GO:0034388" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|protein binding|nucleoplasm|chromosome|nucleolus|rRNA processing|snoRNA binding|small-subunit processome|Pwp2p-containing subcomplex of 90S preribosome" hsa03008 Ribosome biogenesis in eukaryotes UTRN 1590.93602 1633.449796 1548.422245 0.947946028 -0.077123175 0.747862565 1 5.370185021 5.005460499 7402 utrophin "GO:0001954,GO:0003779,GO:0005178,GO:0005515,GO:0005654,GO:0005737,GO:0005856,GO:0005886,GO:0006936,GO:0007517,GO:0007528,GO:0008270,GO:0014894,GO:0016010,GO:0016020,GO:0017166,GO:0019901,GO:0030175,GO:0030426,GO:0030864,GO:0031527,GO:0031594,GO:0032991,GO:0042383,GO:0045211,GO:0051015,GO:0070062,GO:0070938,GO:2000649" positive regulation of cell-matrix adhesion|actin binding|integrin binding|protein binding|nucleoplasm|cytoplasm|cytoskeleton|plasma membrane|muscle contraction|muscle organ development|neuromuscular junction development|zinc ion binding|response to denervation involved in regulation of muscle adaptation|dystrophin-associated glycoprotein complex|membrane|vinculin binding|protein kinase binding|filopodium|growth cone|cortical actin cytoskeleton|filopodium membrane|neuromuscular junction|protein-containing complex|sarcolemma|postsynaptic membrane|actin filament binding|extracellular exosome|contractile ring|regulation of sodium ion transmembrane transporter activity UTS2B 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.014950182 0.040740527 257313 urotensin 2B "GO:0001664,GO:0005179,GO:0005576,GO:0007186,GO:0008217,GO:0097746" G protein-coupled receptor binding|hormone activity|extracellular region|G protein-coupled receptor signaling pathway|regulation of blood pressure|blood vessel diameter maintenance hsa04080 Neuroactive ligand-receptor interaction UVRAG 748.0769735 752.2192372 743.9347099 0.988986552 -0.015977191 0.955544832 1 4.735703452 4.605174213 7405 UV radiation resistance associated "GO:0000149,GO:0000323,GO:0000421,GO:0000775,GO:0005515,GO:0005737,GO:0005764,GO:0005768,GO:0005769,GO:0005770,GO:0005783,GO:0005813,GO:0006281,GO:0006890,GO:0006914,GO:0007051,GO:0007059,GO:0007098,GO:0017124,GO:0030496,GO:0032465,GO:0032801,GO:0035493,GO:0045335,GO:0046718,GO:0051684,GO:0070418,GO:0071900,GO:0071985,GO:0097352,GO:0097680,GO:1901098" "SNARE binding|lytic vacuole|autophagosome membrane|chromosome, centromeric region|protein binding|cytoplasm|lysosome|endosome|early endosome|late endosome|endoplasmic reticulum|centrosome|DNA repair|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|autophagy|spindle organization|chromosome segregation|centrosome cycle|SH3 domain binding|midbody|regulation of cytokinesis|receptor catabolic process|SNARE complex assembly|phagocytic vesicle|viral entry into host cell|maintenance of Golgi location|DNA-dependent protein kinase complex|regulation of protein serine/threonine kinase activity|multivesicular body sorting pathway|autophagosome maturation|double-strand break repair via classical nonhomologous end joining|positive regulation of autophagosome maturation" hsa04140 Autophagy - animal UVSSA 463.2841597 479.6307999 446.9375195 0.93183657 -0.101851144 0.720113101 1 1.532571804 1.404209026 57654 UV stimulated scaffold protein A "GO:0000993,GO:0005515,GO:0005654,GO:0005694,GO:0006283,GO:0009411,GO:0016567" RNA polymerase II complex binding|protein binding|nucleoplasm|chromosome|transcription-coupled nucleotide-excision repair|response to UV|protein ubiquitination UXS1 1753.078883 1663.621798 1842.535968 1.107544978 0.147365288 0.535434894 1 23.38278582 25.46412763 80146 UDP-glucuronate decarboxylase 1 "GO:0005737,GO:0016021,GO:0032580,GO:0033320,GO:0042802,GO:0042803,GO:0048040,GO:0070062,GO:0070403,GO:1902494" cytoplasm|integral component of membrane|Golgi cisterna membrane|UDP-D-xylose biosynthetic process|identical protein binding|protein homodimerization activity|UDP-glucuronate decarboxylase activity|extracellular exosome|NAD+ binding|catalytic complex hsa00520 Amino sugar and nucleotide sugar metabolism UXT 934.6890696 882.2709725 987.1071668 1.118825392 0.161984902 0.51433077 1 60.91226424 67.00978682 8409 ubiquitously expressed prefoldin like chaperone "GO:0000122,GO:0000226,GO:0000785,GO:0000922,GO:0000930,GO:0003682,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005856,GO:0006915,GO:0007098,GO:0008017,GO:0016592,GO:0045944,GO:0047497,GO:0048487,GO:0051015,GO:0070317" negative regulation of transcription by RNA polymerase II|microtubule cytoskeleton organization|chromatin|spindle pole|gamma-tubulin complex|chromatin binding|transcription coregulator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytoskeleton|apoptotic process|centrosome cycle|microtubule binding|mediator complex|positive regulation of transcription by RNA polymerase II|mitochondrion transport along microtubule|beta-tubulin binding|actin filament binding|negative regulation of G0 to G1 transition VAC14 1649.025591 1783.269395 1514.781787 0.849440803 -0.235414685 0.322211101 1 5.241205534 4.377594077 55697 VAC14 component of PIKFYVE complex "GO:0000139,GO:0000306,GO:0005515,GO:0005783,GO:0005829,GO:0006661,GO:0007165,GO:0010008,GO:0016032,GO:0031901,GO:0031902,GO:0033674,GO:0038023,GO:0042802,GO:0043231,GO:0070772" Golgi membrane|extrinsic component of vacuolar membrane|protein binding|endoplasmic reticulum|cytosol|phosphatidylinositol biosynthetic process|signal transduction|endosome membrane|viral process|early endosome membrane|late endosome membrane|positive regulation of kinase activity|signaling receptor activity|identical protein binding|intracellular membrane-bounded organelle|PAS complex "hsa05166,hsa05203" Human T-cell leukemia virus 1 infection|Viral carcinogenesis VAMP1 199.2455177 184.1532572 214.3377782 1.163909786 0.21897924 0.554186401 1 3.130908212 3.583115717 6843 vesicle associated membrane protein 1 "GO:0005484,GO:0005515,GO:0005741,GO:0005829,GO:0005886,GO:0005887,GO:0006906,GO:0019905,GO:0030285,GO:0030672,GO:0031201,GO:0035493,GO:0035577,GO:0035579,GO:0043005,GO:0070821" SNAP receptor activity|protein binding|mitochondrial outer membrane|cytosol|plasma membrane|integral component of plasma membrane|vesicle fusion|syntaxin binding|integral component of synaptic vesicle membrane|synaptic vesicle membrane|SNARE complex|SNARE complex assembly|azurophil granule membrane|specific granule membrane|neuron projection|tertiary granule membrane hsa04130 SNARE interactions in vesicular transport VAMP2 517.7479871 483.7924554 551.7035187 1.140372307 0.189504911 0.487326209 1 10.08165333 11.30445425 6844 vesicle associated membrane protein 2 "GO:0000149,GO:0005484,GO:0005515,GO:0005516,GO:0005543,GO:0005802,GO:0005829,GO:0005886,GO:0005887,GO:0006887,GO:0006892,GO:0006906,GO:0007269,GO:0008021,GO:0008076,GO:0009749,GO:0014047,GO:0015031,GO:0016020,GO:0016079,GO:0016192,GO:0017075,GO:0017156,GO:0017157,GO:0019905,GO:0030136,GO:0030141,GO:0030665,GO:0030667,GO:0030672,GO:0031201,GO:0031410,GO:0031982,GO:0032869,GO:0035493,GO:0042589,GO:0043001,GO:0043005,GO:0043231,GO:0043308,GO:0043312,GO:0043320,GO:0043621,GO:0044306,GO:0045202,GO:0048306,GO:0048471,GO:0048488,GO:0060203,GO:0060291,GO:0060627,GO:0061024,GO:0061025,GO:0061202,GO:0065003,GO:0070032,GO:0070033,GO:0070044,GO:0070083,GO:0070254,GO:0090316,GO:1902259,GO:1903593" SNARE binding|SNAP receptor activity|protein binding|calmodulin binding|phospholipid binding|trans-Golgi network|cytosol|plasma membrane|integral component of plasma membrane|exocytosis|post-Golgi vesicle-mediated transport|vesicle fusion|neurotransmitter secretion|synaptic vesicle|voltage-gated potassium channel complex|response to glucose|glutamate secretion|protein transport|membrane|synaptic vesicle exocytosis|vesicle-mediated transport|syntaxin-1 binding|calcium-ion regulated exocytosis|regulation of exocytosis|syntaxin binding|clathrin-coated vesicle|secretory granule|clathrin-coated vesicle membrane|secretory granule membrane|synaptic vesicle membrane|SNARE complex|cytoplasmic vesicle|vesicle|cellular response to insulin stimulus|SNARE complex assembly|zymogen granule membrane|Golgi to plasma membrane protein transport|neuron projection|intracellular membrane-bounded organelle|eosinophil degranulation|neutrophil degranulation|natural killer cell degranulation|protein self-association|neuron projection terminus|synapse|calcium-dependent protein binding|perinuclear region of cytoplasm|synaptic vesicle endocytosis|clathrin-sculpted glutamate transport vesicle membrane|long-term synaptic potentiation|regulation of vesicle-mediated transport|membrane organization|membrane fusion|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|protein-containing complex assembly|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex|synaptobrevin 2-SNAP-25-syntaxin-1a complex|clathrin-sculpted monoamine transport vesicle membrane|mucus secretion|positive regulation of intracellular protein transport|regulation of delayed rectifier potassium channel activity|regulation of histamine secretion by mast cell "hsa04130,hsa04721,hsa04911,hsa04962,hsa04970" SNARE interactions in vesicular transport|Synaptic vesicle cycle|Insulin secretion|Vasopressin-regulated water reabsorption|Salivary secretion VAMP3 4192.327541 3564.457962 4820.197119 1.352294562 0.43540944 0.068144693 1 86.50685322 115.0251994 9341 vesicle associated membrane protein 3 "GO:0001921,GO:0002479,GO:0002639,GO:0005484,GO:0005515,GO:0005769,GO:0005829,GO:0005886,GO:0006887,GO:0006904,GO:0006906,GO:0009986,GO:0016021,GO:0016192,GO:0016324,GO:0017075,GO:0017156,GO:0019905,GO:0030133,GO:0030136,GO:0030141,GO:0030285,GO:0030665,GO:0030670,GO:0031201,GO:0032588,GO:0034446,GO:0035493,GO:0042147,GO:0043001,GO:0043005,GO:0043231,GO:0048471,GO:0055037,GO:0055038,GO:0061024,GO:0061025,GO:0065003,GO:0070254,GO:0071346,GO:1903531,GO:1903593" "positive regulation of receptor recycling|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|positive regulation of immunoglobulin production|SNAP receptor activity|protein binding|early endosome|cytosol|plasma membrane|exocytosis|vesicle docking involved in exocytosis|vesicle fusion|cell surface|integral component of membrane|vesicle-mediated transport|apical plasma membrane|syntaxin-1 binding|calcium-ion regulated exocytosis|syntaxin binding|transport vesicle|clathrin-coated vesicle|secretory granule|integral component of synaptic vesicle membrane|clathrin-coated vesicle membrane|phagocytic vesicle membrane|SNARE complex|trans-Golgi network membrane|substrate adhesion-dependent cell spreading|SNARE complex assembly|retrograde transport, endosome to Golgi|Golgi to plasma membrane protein transport|neuron projection|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|recycling endosome|recycling endosome membrane|membrane organization|membrane fusion|protein-containing complex assembly|mucus secretion|cellular response to interferon-gamma|negative regulation of secretion by cell|regulation of histamine secretion by mast cell" "hsa04130,hsa04145" SNARE interactions in vesicular transport|Phagosome VAMP4 794.6433476 776.1487565 813.1379388 1.047657336 0.067166923 0.793940171 1 7.196253063 7.413048891 8674 vesicle associated membrane protein 4 "GO:0000139,GO:0000226,GO:0005515,GO:0005764,GO:0005768,GO:0005794,GO:0005802,GO:0005886,GO:0006888,GO:0008021,GO:0009986,GO:0016189,GO:0030133,GO:0030285,GO:0030665,GO:0031201,GO:0032588,GO:0035493,GO:0043001,GO:0061024,GO:0090161,GO:1900242" Golgi membrane|microtubule cytoskeleton organization|protein binding|lysosome|endosome|Golgi apparatus|trans-Golgi network|plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|synaptic vesicle|cell surface|synaptic vesicle to endosome fusion|transport vesicle|integral component of synaptic vesicle membrane|clathrin-coated vesicle membrane|SNARE complex|trans-Golgi network membrane|SNARE complex assembly|Golgi to plasma membrane protein transport|membrane organization|Golgi ribbon formation|regulation of synaptic vesicle endocytosis hsa04130 SNARE interactions in vesicular transport VAMP5 256.1367727 226.8102264 285.4633189 1.258599859 0.331819686 0.319908816 1 18.34006807 22.69654756 10791 vesicle associated membrane protein 5 "GO:0005515,GO:0005770,GO:0005794,GO:0005886,GO:0005887,GO:0007517,GO:0007519,GO:0009986,GO:0014704,GO:0030154,GO:0030659,GO:0031301,GO:0043001,GO:0048471,GO:0070062" protein binding|late endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|muscle organ development|skeletal muscle tissue development|cell surface|intercalated disc|cell differentiation|cytoplasmic vesicle membrane|integral component of organelle membrane|Golgi to plasma membrane protein transport|perinuclear region of cytoplasm|extracellular exosome hsa04130 SNARE interactions in vesicular transport VAMP7 35.94899917 35.37407201 36.52392633 1.032505568 0.046149562 0.992801931 1 0.738595152 0.749842469 6845 vesicle associated membrane protein 7 "GO:0000149,GO:0005484,GO:0005515,GO:0005737,GO:0005765,GO:0005789,GO:0005802,GO:0005886,GO:0006887,GO:0006888,GO:0006892,GO:0006906,GO:0006911,GO:0008333,GO:0015031,GO:0016020,GO:0016192,GO:0017156,GO:0019905,GO:0030027,GO:0030141,GO:0030175,GO:0030285,GO:0030665,GO:0030667,GO:0030670,GO:0031091,GO:0031143,GO:0031201,GO:0031902,GO:0034197,GO:0035577,GO:0043005,GO:0043231,GO:0043308,GO:0043312,GO:0043320,GO:0045335,GO:0047496,GO:0048280,GO:0048471,GO:0061024,GO:0070062,GO:0097352,GO:0098686,GO:1903595" "SNARE binding|SNAP receptor activity|protein binding|cytoplasm|lysosomal membrane|endoplasmic reticulum membrane|trans-Golgi network|plasma membrane|exocytosis|endoplasmic reticulum to Golgi vesicle-mediated transport|post-Golgi vesicle-mediated transport|vesicle fusion|phagocytosis, engulfment|endosome to lysosome transport|protein transport|membrane|vesicle-mediated transport|calcium-ion regulated exocytosis|syntaxin binding|lamellipodium|secretory granule|filopodium|integral component of synaptic vesicle membrane|clathrin-coated vesicle membrane|secretory granule membrane|phagocytic vesicle membrane|platelet alpha granule|pseudopodium|SNARE complex|late endosome membrane|triglyceride transport|azurophil granule membrane|neuron projection|intracellular membrane-bounded organelle|eosinophil degranulation|neutrophil degranulation|natural killer cell degranulation|phagocytic vesicle|vesicle transport along microtubule|vesicle fusion with Golgi apparatus|perinuclear region of cytoplasm|membrane organization|extracellular exosome|autophagosome maturation|hippocampal mossy fiber to CA3 synapse|positive regulation of histamine secretion by mast cell" hsa04130 SNARE interactions in vesicular transport VAMP8 1290.71122 1195.435551 1385.986889 1.159399089 0.213377257 0.376121951 1 73.92606981 84.27558024 8673 vesicle associated membrane protein 8 "GO:0002479,GO:0005484,GO:0005515,GO:0005737,GO:0005765,GO:0005769,GO:0005829,GO:0005886,GO:0006892,GO:0006906,GO:0015031,GO:0016020,GO:0016021,GO:0016240,GO:0019869,GO:0019905,GO:0030665,GO:0030667,GO:0030670,GO:0031201,GO:0031901,GO:0031902,GO:0031982,GO:0035493,GO:0035577,GO:0035579,GO:0043308,GO:0043312,GO:0046718,GO:0048471,GO:0051607,GO:0055037,GO:0055038,GO:0061024,GO:0070062,GO:0070254,GO:0070821,GO:0097352,GO:0098594,GO:1903076,GO:1903531,GO:1903595" "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|SNAP receptor activity|protein binding|cytoplasm|lysosomal membrane|early endosome|cytosol|plasma membrane|post-Golgi vesicle-mediated transport|vesicle fusion|protein transport|membrane|integral component of membrane|autophagosome membrane docking|chloride channel inhibitor activity|syntaxin binding|clathrin-coated vesicle membrane|secretory granule membrane|phagocytic vesicle membrane|SNARE complex|early endosome membrane|late endosome membrane|vesicle|SNARE complex assembly|azurophil granule membrane|specific granule membrane|eosinophil degranulation|neutrophil degranulation|viral entry into host cell|perinuclear region of cytoplasm|defense response to virus|recycling endosome|recycling endosome membrane|membrane organization|extracellular exosome|mucus secretion|tertiary granule membrane|autophagosome maturation|mucin granule|regulation of protein localization to plasma membrane|negative regulation of secretion by cell|positive regulation of histamine secretion by mast cell" "hsa04130,hsa04140,hsa04611" SNARE interactions in vesicular transport|Autophagy - animal|Platelet activation VANGL1 1624.833146 1791.592706 1458.073585 0.813842108 -0.297179167 0.211481843 1 10.9285644 8.745294739 81839 VANGL planar cell polarity protein 1 "GO:0005515,GO:0005886,GO:0007275,GO:0016021,GO:0016328,GO:0043473,GO:0060071" "protein binding|plasma membrane|multicellular organism development|integral component of membrane|lateral plasma membrane|pigmentation|Wnt signaling pathway, planar cell polarity pathway" hsa04310 Wnt signaling pathway VAPA 3340.477865 3229.444692 3451.511038 1.068763013 0.095941986 0.686487641 1 39.45730946 41.46484651 9218 VAMP associated protein A "GO:0000139,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0005923,GO:0006888,GO:0007029,GO:0008017,GO:0008219,GO:0016021,GO:0016032,GO:0019904,GO:0030148,GO:0031175,GO:0031965,GO:0031982,GO:0033149,GO:0034975,GO:0035577,GO:0043123,GO:0043312,GO:0044791,GO:0044828,GO:0044829,GO:0045296,GO:0046982,GO:0048471,GO:0061025,GO:0070971,GO:0070972,GO:0090114" Golgi membrane|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|bicellular tight junction|endoplasmic reticulum to Golgi vesicle-mediated transport|endoplasmic reticulum organization|microtubule binding|cell death|integral component of membrane|viral process|protein domain specific binding|sphingolipid biosynthetic process|neuron projection development|nuclear membrane|vesicle|FFAT motif binding|protein folding in endoplasmic reticulum|azurophil granule membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|neutrophil degranulation|positive regulation by host of viral release from host cell|negative regulation by host of viral genome replication|positive regulation by host of viral genome replication|cadherin binding|protein heterodimerization activity|perinuclear region of cytoplasm|membrane fusion|endoplasmic reticulum exit site|protein localization to endoplasmic reticulum|COPII-coated vesicle budding hsa04979 Cholesterol metabolism VAPB 2080.840667 2042.332452 2119.348883 1.037710037 0.053403373 0.823099062 1 13.92202443 14.20527309 9217 VAMP associated protein B and C "GO:0000139,GO:0005515,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0006874,GO:0006888,GO:0007029,GO:0008017,GO:0016021,GO:0019048,GO:0019899,GO:0030148,GO:0030968,GO:0033149,GO:0036498,GO:0042803,GO:0045070,GO:0045296,GO:0046982,GO:0048487,GO:0061817,GO:0070971,GO:0090114,GO:0090158" Golgi membrane|protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|cellular calcium ion homeostasis|endoplasmic reticulum to Golgi vesicle-mediated transport|endoplasmic reticulum organization|microtubule binding|integral component of membrane|modulation by virus of host process|enzyme binding|sphingolipid biosynthetic process|endoplasmic reticulum unfolded protein response|FFAT motif binding|IRE1-mediated unfolded protein response|protein homodimerization activity|positive regulation of viral genome replication|cadherin binding|protein heterodimerization activity|beta-tubulin binding|endoplasmic reticulum-plasma membrane tethering|endoplasmic reticulum exit site|COPII-coated vesicle budding|endoplasmic reticulum membrane organization "hsa04979,hsa05014,hsa05022" Cholesterol metabolism|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases VARS1 1970.466248 2046.494107 1894.438389 0.925699411 -0.111384291 0.63902328 1 27.81905991 25.32116106 7407 valyl-tRNA synthetase 1 "GO:0002161,GO:0004832,GO:0005515,GO:0005524,GO:0005829,GO:0006418,GO:0006438,GO:0106074" aminoacyl-tRNA editing activity|valine-tRNA ligase activity|protein binding|ATP binding|cytosol|tRNA aminoacylation for protein translation|valyl-tRNA aminoacylation|aminoacyl-tRNA metabolism involved in translational fidelity hsa00970 Aminoacyl-tRNA biosynthesis VARS2 619.8821547 654.4203322 585.3439772 0.894446502 -0.160932899 0.540789222 1 9.755645351 8.579886695 57176 "valyl-tRNA synthetase 2, mitochondrial" "GO:0002161,GO:0004832,GO:0005515,GO:0005524,GO:0005739,GO:0005829,GO:0006438,GO:0106074" aminoacyl-tRNA editing activity|valine-tRNA ligase activity|protein binding|ATP binding|mitochondrion|cytosol|valyl-tRNA aminoacylation|aminoacyl-tRNA metabolism involved in translational fidelity hsa00970 Aminoacyl-tRNA biosynthesis VASH1 209.5408305 176.87036 242.2113009 1.369428438 0.453573877 0.204844476 1 1.409263368 1.897591316 22846 vasohibin 1 "GO:0001525,GO:0001937,GO:0003779,GO:0004181,GO:0005515,GO:0005615,GO:0005737,GO:0005783,GO:0006508,GO:0007050,GO:0009611,GO:0010596,GO:0016525,GO:0043537,GO:0045177,GO:0045765,GO:0060716,GO:1901491,GO:2000772" angiogenesis|negative regulation of endothelial cell proliferation|actin binding|metallocarboxypeptidase activity|protein binding|extracellular space|cytoplasm|endoplasmic reticulum|proteolysis|cell cycle arrest|response to wounding|negative regulation of endothelial cell migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|apical part of cell|regulation of angiogenesis|labyrinthine layer blood vessel development|negative regulation of lymphangiogenesis|regulation of cellular senescence VASH2 64.6496997 69.70773014 59.59166927 0.854878923 -0.22620799 0.698152515 1 0.869809081 0.731138622 79805 vasohibin 2 "GO:0000768,GO:0001938,GO:0003779,GO:0004181,GO:0005515,GO:0005576,GO:0005737,GO:0005856,GO:0006508,GO:0008017,GO:0045765,GO:0045766,GO:0060716,GO:0061564,GO:0140253" syncytium formation by plasma membrane fusion|positive regulation of endothelial cell proliferation|actin binding|metallocarboxypeptidase activity|protein binding|extracellular region|cytoplasm|cytoskeleton|proteolysis|microtubule binding|regulation of angiogenesis|positive regulation of angiogenesis|labyrinthine layer blood vessel development|axon development|cell-cell fusion VASN 5.003924597 5.202069413 4.80577978 0.923820772 -0.11431511 1 1 0.098588382 0.089553928 114990 vasorin "GO:0005515,GO:0005615,GO:0005739,GO:0005765,GO:0005886,GO:0009986,GO:0010719,GO:0016021,GO:0030512,GO:0031012,GO:0045296,GO:0050431,GO:0070062,GO:0071456,GO:0071461" protein binding|extracellular space|mitochondrion|lysosomal membrane|plasma membrane|cell surface|negative regulation of epithelial to mesenchymal transition|integral component of membrane|negative regulation of transforming growth factor beta receptor signaling pathway|extracellular matrix|cadherin binding|transforming growth factor beta binding|extracellular exosome|cellular response to hypoxia|cellular response to redox state VASP 2044.758304 1940.371891 2149.144718 1.107594234 0.147429448 0.533881374 1 45.77987691 49.85703935 7408 vasodilator stimulated phosphoprotein "GO:0001843,GO:0003779,GO:0005515,GO:0005522,GO:0005829,GO:0005886,GO:0005923,GO:0005925,GO:0007411,GO:0008154,GO:0015629,GO:0017124,GO:0030036,GO:0030838,GO:0031258,GO:0031527,GO:0034329,GO:0045296,GO:0051289,GO:0070062" neural tube closure|actin binding|protein binding|profilin binding|cytosol|plasma membrane|bicellular tight junction|focal adhesion|axon guidance|actin polymerization or depolymerization|actin cytoskeleton|SH3 domain binding|actin cytoskeleton organization|positive regulation of actin filament polymerization|lamellipodium membrane|filopodium membrane|cell junction assembly|cadherin binding|protein homotetramerization|extracellular exosome "hsa04015,hsa04022,hsa04510,hsa04530,hsa04611,hsa04666,hsa04670" Rap1 signaling pathway|cGMP-PKG signaling pathway|Focal adhesion|Tight junction|Platelet activation|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration VAT1 9492.478829 9187.894998 9797.062659 1.066301113 0.092614898 0.711381911 1 181.6750905 190.4787035 10493 vesicle amine transport 1 "GO:0005515,GO:0005576,GO:0005741,GO:0008270,GO:0010637,GO:0016021,GO:0016491,GO:0035578,GO:0043312,GO:0055114,GO:0070062" protein binding|extracellular region|mitochondrial outer membrane|zinc ion binding|negative regulation of mitochondrial fusion|integral component of membrane|oxidoreductase activity|azurophil granule lumen|neutrophil degranulation|oxidation-reduction process|extracellular exosome VAT1L 3.522561699 4.161655531 2.883467868 0.692865579 -0.529352609 0.940314863 1 0.0585861 0.039913035 57687 vesicle amine transport 1 like "GO:0005515,GO:0008270,GO:0016491,GO:0055114" protein binding|zinc ion binding|oxidoreductase activity|oxidation-reduction process VAV2 1800.462374 1746.854909 1854.069839 1.061375979 0.085935803 0.71860864 1 13.91854821 14.52560972 7410 vav guanine nucleotide exchange factor 2 "GO:0001525,GO:0001784,GO:0005085,GO:0005154,GO:0005515,GO:0005829,GO:0005886,GO:0007165,GO:0007186,GO:0007264,GO:0008361,GO:0016477,GO:0030032,GO:0030168,GO:0038095,GO:0038096,GO:0043065,GO:0043087,GO:0043552,GO:0046872,GO:0048010,GO:0048013,GO:0051056" angiogenesis|phosphotyrosine residue binding|guanyl-nucleotide exchange factor activity|epidermal growth factor receptor binding|protein binding|cytosol|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|small GTPase mediated signal transduction|regulation of cell size|cell migration|lamellipodium assembly|platelet activation|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of apoptotic process|regulation of GTPase activity|positive regulation of phosphatidylinositol 3-kinase activity|metal ion binding|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|regulation of small GTPase mediated signal transduction "hsa04015,hsa04024,hsa04062,hsa04510,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04670,hsa04810,hsa05135,hsa05205" Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Focal adhesion|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Yersinia infection|Proteoglycans in cancer VAX2 64.96673141 78.0310412 51.90242162 0.665150956 -0.588246298 0.283332264 1 0.97640639 0.638589849 25806 ventral anterior homeobox 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001162,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0007398,GO:0007409,GO:0007417,GO:0007601,GO:0009950,GO:0016055,GO:0030182,GO:0030900,GO:0031490,GO:0048048,GO:0060041,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|ectoderm development|axonogenesis|central nervous system development|visual perception|dorsal/ventral axis specification|Wnt signaling pathway|neuron differentiation|forebrain development|chromatin DNA binding|embryonic eye morphogenesis|retina development in camera-type eye|sequence-specific double-stranded DNA binding" VBP1 2553.723753 2155.737565 2951.709941 1.369234358 0.453369399 0.055341658 1 56.28559284 75.77853617 7411 VHL binding protein 1 "GO:0001540,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0006457,GO:0007017,GO:0007021,GO:0015631,GO:0016272,GO:0043231,GO:0051082,GO:1905907" amyloid-beta binding|protein binding|nucleus|cytoplasm|cytosol|polysome|protein folding|microtubule-based process|tubulin complex assembly|tubulin binding|prefoldin complex|intracellular membrane-bounded organelle|unfolded protein binding|negative regulation of amyloid fibril formation VCAN 5735.331639 5680.659799 5790.003479 1.019248412 0.027505709 0.910053864 1 24.55782688 24.6116741 1462 versican "GO:0001501,GO:0001649,GO:0001750,GO:0005509,GO:0005515,GO:0005539,GO:0005540,GO:0005576,GO:0005615,GO:0005788,GO:0005796,GO:0007155,GO:0007275,GO:0007417,GO:0008037,GO:0016020,GO:0030021,GO:0030198,GO:0030206,GO:0030207,GO:0030208,GO:0030246,GO:0031012,GO:0033165,GO:0043202,GO:0043687,GO:0044267,GO:0062023" skeletal system development|osteoblast differentiation|photoreceptor outer segment|calcium ion binding|protein binding|glycosaminoglycan binding|hyaluronic acid binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi lumen|cell adhesion|multicellular organism development|central nervous system development|cell recognition|membrane|extracellular matrix structural constituent conferring compression resistance|extracellular matrix organization|chondroitin sulfate biosynthetic process|chondroitin sulfate catabolic process|dermatan sulfate biosynthetic process|carbohydrate binding|extracellular matrix|interphotoreceptor matrix|lysosomal lumen|post-translational protein modification|cellular protein metabolic process|collagen-containing extracellular matrix hsa04514 Cell adhesion molecules VCL 13181.74207 14092.40604 12271.07809 0.870758198 -0.199655944 0.439978228 1 136.8175022 117.1413994 7414 vinculin "GO:0002009,GO:0002102,GO:0002162,GO:0002576,GO:0003779,GO:0005198,GO:0005515,GO:0005576,GO:0005829,GO:0005856,GO:0005911,GO:0005912,GO:0005916,GO:0005925,GO:0006936,GO:0007155,GO:0007160,GO:0008013,GO:0030032,GO:0030055,GO:0030336,GO:0031625,GO:0032991,GO:0034333,GO:0034394,GO:0034774,GO:0035580,GO:0035633,GO:0042383,GO:0043034,GO:0043297,GO:0043312,GO:0044291,GO:0045294,GO:0045296,GO:0048675,GO:0051893,GO:0070062,GO:0070527,GO:0090136,GO:1903140,GO:1903561,GO:1904702,GO:1904813" morphogenesis of an epithelium|podosome|dystroglycan binding|platelet degranulation|actin binding|structural molecule activity|protein binding|extracellular region|cytosol|cytoskeleton|cell-cell junction|adherens junction|fascia adherens|focal adhesion|muscle contraction|cell adhesion|cell-matrix adhesion|beta-catenin binding|lamellipodium assembly|cell-substrate junction|negative regulation of cell migration|ubiquitin protein ligase binding|protein-containing complex|adherens junction assembly|protein localization to cell surface|secretory granule lumen|specific granule lumen|maintenance of blood-brain barrier|sarcolemma|costamere|apical junction assembly|neutrophil degranulation|cell-cell contact zone|alpha-catenin binding|cadherin binding|axon extension|regulation of focal adhesion assembly|extracellular exosome|platelet aggregation|epithelial cell-cell adhesion|regulation of establishment of endothelial barrier|extracellular vesicle|regulation of protein localization to adherens junction|ficolin-1-rich granule lumen "hsa04510,hsa04520,hsa04670,hsa04810,hsa05100,hsa05131,hsa05146" Focal adhesion|Adherens junction|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Shigellosis|Amoebiasis VCP 9574.780351 9380.371566 9769.189137 1.041450125 0.05859375 0.815219742 1 115.7219579 118.5019312 7415 valosin containing protein "GO:0000502,GO:0003723,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0005811,GO:0005829,GO:0006281,GO:0006302,GO:0006457,GO:0006734,GO:0006888,GO:0006914,GO:0006919,GO:0006974,GO:0008289,GO:0010494,GO:0010498,GO:0010918,GO:0016236,GO:0016567,GO:0016579,GO:0016887,GO:0019079,GO:0019903,GO:0019904,GO:0019985,GO:0030433,GO:0030968,GO:0030970,GO:0031334,GO:0031593,GO:0031625,GO:0032436,GO:0032510,GO:0032991,GO:0034098,GO:0034605,GO:0034774,GO:0035578,GO:0035617,GO:0035800,GO:0035861,GO:0036297,GO:0036435,GO:0036503,GO:0036513,GO:0042288,GO:0042802,GO:0042981,GO:0043161,GO:0043231,GO:0043312,GO:0043531,GO:0044389,GO:0045184,GO:0045732,GO:0045879,GO:0046034,GO:0048471,GO:0050807,GO:0051228,GO:0055085,GO:0061857,GO:0070062,GO:0070842,GO:0070987,GO:0071712,GO:0072389,GO:0090263,GO:0097352,GO:0098978,GO:0106300,GO:1903006,GO:1903007,GO:1903715,GO:1903843,GO:1903862,GO:1904288,GO:1904813,GO:1904949,GO:1905634,GO:1990381,GO:1990730,GO:2000158,GO:2001171" "proteasome complex|RNA binding|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|cytosol|DNA repair|double-strand break repair|protein folding|NADH metabolic process|endoplasmic reticulum to Golgi vesicle-mediated transport|autophagy|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to DNA damage stimulus|lipid binding|cytoplasmic stress granule|proteasomal protein catabolic process|positive regulation of mitochondrial membrane potential|macroautophagy|protein ubiquitination|protein deubiquitination|ATPase activity|viral genome replication|protein phosphatase binding|protein domain specific binding|translesion synthesis|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|retrograde protein transport, ER to cytosol|positive regulation of protein-containing complex assembly|polyubiquitin modification-dependent protein binding|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|endosome to lysosome transport via multivesicular body sorting pathway|protein-containing complex|VCP-NPL4-UFD1 AAA ATPase complex|cellular response to heat|secretory granule lumen|azurophil granule lumen|stress granule disassembly|deubiquitinase activator activity|site of double-strand break|interstrand cross-link repair|K48-linked polyubiquitin modification-dependent protein binding|ERAD pathway|Derlin-1 retrotranslocation complex|MHC class I protein binding|identical protein binding|regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|neutrophil degranulation|ADP binding|ubiquitin-like protein ligase binding|establishment of protein localization|positive regulation of protein catabolic process|negative regulation of smoothened signaling pathway|ATP metabolic process|perinuclear region of cytoplasm|regulation of synapse organization|mitotic spindle disassembly|transmembrane transport|endoplasmic reticulum stress-induced pre-emptive quality control|extracellular exosome|aggresome assembly|error-free translesion synthesis|ER-associated misfolded protein catabolic process|flavin adenine dinucleotide catabolic process|positive regulation of canonical Wnt signaling pathway|autophagosome maturation|glutamatergic synapse|protein-DNA covalent cross-linking repair|positive regulation of protein K63-linked deubiquitination|positive regulation of Lys63-specific deubiquitinase activity|regulation of aerobic respiration|cellular response to arsenite ion|positive regulation of oxidative phosphorylation|BAT3 complex binding|ficolin-1-rich granule lumen|ATPase complex|regulation of protein localization to chromatin|ubiquitin-specific protease binding|VCP-NSFL1C complex|positive regulation of ubiquitin-specific protease activity|positive regulation of ATP biosynthetic process" "hsa04141,hsa05014,hsa05022,hsa05134" Protein processing in endoplasmic reticulum|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Legionellosis VCPIP1 1107.650639 1196.475965 1018.825313 0.851521755 -0.231884706 0.341749973 1 6.413592128 5.369925543 80124 valosin containing protein interacting protein 1 "GO:0000278,GO:0004843,GO:0005634,GO:0005737,GO:0005788,GO:0005795,GO:0006974,GO:0008234,GO:0016320,GO:0016567,GO:0016579,GO:0018215,GO:0035871,GO:0071108,GO:0090168,GO:0106300,GO:1905634" mitotic cell cycle|thiol-dependent ubiquitin-specific protease activity|nucleus|cytoplasm|endoplasmic reticulum lumen|Golgi stack|cellular response to DNA damage stimulus|cysteine-type peptidase activity|endoplasmic reticulum membrane fusion|protein ubiquitination|protein deubiquitination|protein phosphopantetheinylation|protein K11-linked deubiquitination|protein K48-linked deubiquitination|Golgi reassembly|protein-DNA covalent cross-linking repair|regulation of protein localization to chromatin VCPKMT 151.2820691 148.7791852 153.784953 1.033645619 0.047741648 0.923199043 1 0.920161278 0.935204957 79609 valosin containing protein lysine methyltransferase "GO:0005515,GO:0005737,GO:0005829,GO:0006479,GO:0016279,GO:0018022,GO:0018023,GO:0032780,GO:0032991,GO:0051117" protein binding|cytoplasm|cytosol|protein methylation|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation|peptidyl-lysine trimethylation|negative regulation of ATPase activity|protein-containing complex|ATPase binding VDAC1 5458.17581 5040.805261 5875.546359 1.165596776 0.221068792 0.359063346 1 116.4582304 133.4718569 7416 voltage dependent anion channel 1 "GO:0001662,GO:0005515,GO:0005634,GO:0005739,GO:0005741,GO:0005757,GO:0005886,GO:0006090,GO:0006820,GO:0006851,GO:0006915,GO:0007270,GO:0007612,GO:0008021,GO:0008308,GO:0015288,GO:0015485,GO:0015698,GO:0016020,GO:0016032,GO:0016236,GO:0019901,GO:0030855,GO:0031210,GO:0031966,GO:0042645,GO:0042802,GO:0043066,GO:0044325,GO:0044877,GO:0045121,GO:0046930,GO:0070062,GO:0097001,GO:0098656,GO:0110099,GO:1901526,GO:1903146,GO:2000378" behavioral fear response|protein binding|nucleus|mitochondrion|mitochondrial outer membrane|mitochondrial permeability transition pore complex|plasma membrane|pyruvate metabolic process|anion transport|mitochondrial calcium ion transmembrane transport|apoptotic process|neuron-neuron synaptic transmission|learning|synaptic vesicle|voltage-gated anion channel activity|porin activity|cholesterol binding|inorganic anion transport|membrane|viral process|macroautophagy|protein kinase binding|epithelial cell differentiation|phosphatidylcholine binding|mitochondrial membrane|mitochondrial nucleoid|identical protein binding|negative regulation of apoptotic process|ion channel binding|protein-containing complex binding|membrane raft|pore complex|extracellular exosome|ceramide binding|anion transmembrane transport|negative regulation of calcium import into the mitochondrion|positive regulation of mitophagy|regulation of autophagy of mitochondrion|negative regulation of reactive oxygen species metabolic process "hsa04020,hsa04022,hsa04217,hsa04218,hsa04621,hsa04979,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022,hsa05131,hsa05164,hsa05166" Calcium signaling pathway|cGMP-PKG signaling pathway|Necroptosis|Cellular senescence|NOD-like receptor signaling pathway|Cholesterol metabolism|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Shigellosis|Influenza A|Human T-cell leukemia virus 1 infection VDAC2 4794.968024 4270.898988 5319.03706 1.245413922 0.316625312 0.18653514 1 113.2853029 138.726192 7417 voltage dependent anion channel 2 "GO:0000166,GO:0001669,GO:0005515,GO:0005634,GO:0005739,GO:0005741,GO:0006820,GO:0007339,GO:0008021,GO:0008308,GO:0015288,GO:0015485,GO:0015698,GO:0016020,GO:0031210,GO:0031966,GO:0032272,GO:0042645,GO:0046930,GO:0097001,GO:0097345,GO:0098656,GO:2001243" nucleotide binding|acrosomal vesicle|protein binding|nucleus|mitochondrion|mitochondrial outer membrane|anion transport|binding of sperm to zona pellucida|synaptic vesicle|voltage-gated anion channel activity|porin activity|cholesterol binding|inorganic anion transport|membrane|phosphatidylcholine binding|mitochondrial membrane|negative regulation of protein polymerization|mitochondrial nucleoid|pore complex|ceramide binding|mitochondrial outer membrane permeabilization|anion transmembrane transport|negative regulation of intrinsic apoptotic signaling pathway "hsa04020,hsa04022,hsa04216,hsa04217,hsa04218,hsa04621,hsa04979,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05166" Calcium signaling pathway|cGMP-PKG signaling pathway|Ferroptosis|Necroptosis|Cellular senescence|NOD-like receptor signaling pathway|Cholesterol metabolism|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Human T-cell leukemia virus 1 infection VDAC3 1808.989475 1655.298487 1962.680462 1.185695799 0.245733921 0.300146005 1 52.67754201 61.41436444 7419 voltage dependent anion channel 3 "GO:0000166,GO:0005515,GO:0005634,GO:0005739,GO:0005741,GO:0008308,GO:0015288,GO:0015698,GO:0015853,GO:0016020,GO:0046930,GO:0070062,GO:0098656,GO:1902017" nucleotide binding|protein binding|nucleus|mitochondrion|mitochondrial outer membrane|voltage-gated anion channel activity|porin activity|inorganic anion transport|adenine transport|membrane|pore complex|extracellular exosome|anion transmembrane transport|regulation of cilium assembly "hsa04020,hsa04022,hsa04216,hsa04217,hsa04218,hsa04621,hsa04979,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05161,hsa05166,hsa05203" Calcium signaling pathway|cGMP-PKG signaling pathway|Ferroptosis|Necroptosis|Cellular senescence|NOD-like receptor signaling pathway|Cholesterol metabolism|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Hepatitis B|Human T-cell leukemia virus 1 infection|Viral carcinogenesis VDR 370.4879506 491.0753526 249.9005486 0.508884323 -0.974590346 0.001024924 0.197406218 5.112717325 2.558244404 7421 vitamin D receptor "GO:0000122,GO:0000785,GO:0000902,GO:0000978,GO:0000981,GO:0003677,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006367,GO:0007275,GO:0008270,GO:0008285,GO:0010628,GO:0010629,GO:0010839,GO:0010980,GO:0030154,GO:0038183,GO:0038186,GO:0042359,GO:0043235,GO:0045618,GO:0045892,GO:0045944,GO:0046697,GO:0046965,GO:0060558,GO:0070561,GO:0070644,GO:0090575,GO:1902098,GO:1902121" "negative regulation of transcription by RNA polymerase II|chromatin|cell morphogenesis|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytosol|transcription initiation from RNA polymerase II promoter|multicellular organism development|zinc ion binding|negative regulation of cell population proliferation|positive regulation of gene expression|negative regulation of gene expression|negative regulation of keratinocyte proliferation|positive regulation of vitamin D 24-hydroxylase activity|cell differentiation|bile acid signaling pathway|lithocholic acid receptor activity|vitamin D metabolic process|receptor complex|positive regulation of keratinocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|decidualization|retinoid X receptor binding|regulation of calcidiol 1-monooxygenase activity|vitamin D receptor signaling pathway|vitamin D response element binding|RNA polymerase II transcription regulator complex|calcitriol binding|lithocholic acid binding" "hsa04928,hsa04961,hsa04978,hsa05152" "Parathyroid hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Mineral absorption|Tuberculosis" ThyrH_rcpt VEGFA 2384.533309 2520.922838 2248.143781 0.891793968 -0.165217653 0.484999397 1 36.09793898 31.65323599 7422 vascular endothelial growth factor A "GO:0000122,GO:0001525,GO:0001541,GO:0001569,GO:0001570,GO:0001666,GO:0001701,GO:0001822,GO:0001934,GO:0001938,GO:0001968,GO:0002040,GO:0002042,GO:0002052,GO:0002053,GO:0002092,GO:0002576,GO:0002687,GO:0003007,GO:0003151,GO:0003169,GO:0005125,GO:0005161,GO:0005172,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005912,GO:0006357,GO:0007399,GO:0007498,GO:0007595,GO:0008083,GO:0008201,GO:0008284,GO:0008360,GO:0009986,GO:0010595,GO:0010628,GO:0010629,GO:0010749,GO:0016020,GO:0019221,GO:0030141,GO:0030224,GO:0030225,GO:0030324,GO:0030335,GO:0030855,GO:0031012,GO:0031077,GO:0031093,GO:0031334,GO:0031954,GO:0032147,GO:0032793,GO:0033138,GO:0035148,GO:0035767,GO:0035924,GO:0036303,GO:0036324,GO:0038033,GO:0038084,GO:0038091,GO:0038190,GO:0042056,GO:0042462,GO:0042531,GO:0042802,GO:0042803,GO:0043066,GO:0043117,GO:0043129,GO:0043154,GO:0043183,GO:0043184,GO:0043406,GO:0043536,GO:0045766,GO:0045785,GO:0045944,GO:0048010,GO:0048018,GO:0048469,GO:0048593,GO:0048739,GO:0048754,GO:0048842,GO:0048844,GO:0050679,GO:0050731,GO:0050840,GO:0050918,GO:0050927,GO:0050930,GO:0051272,GO:0051781,GO:0051894,GO:0060319,GO:0060749,GO:0060754,GO:0060948,GO:0060982,GO:0061042,GO:0061418,GO:0061419,GO:0071456,GO:0071542,GO:0071679,GO:0090037,GO:0090050,GO:0090190,GO:0090259,GO:0097475,GO:0097533,GO:0120162,GO:1900086,GO:1900745,GO:1901165,GO:1901727,GO:1902336,GO:1903141,GO:1903392,GO:1903572,GO:1903589,GO:1903672,GO:1905604,GO:2000048" negative regulation of transcription by RNA polymerase II|angiogenesis|ovarian follicle development|branching involved in blood vessel morphogenesis|vasculogenesis|response to hypoxia|in utero embryonic development|kidney development|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|fibronectin binding|sprouting angiogenesis|cell migration involved in sprouting angiogenesis|positive regulation of neuroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of receptor internalization|platelet degranulation|positive regulation of leukocyte migration|heart morphogenesis|outflow tract morphogenesis|coronary vein morphogenesis|cytokine activity|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor binding|protein binding|extracellular region|extracellular space|cytoplasm|adherens junction|regulation of transcription by RNA polymerase II|nervous system development|mesoderm development|lactation|growth factor activity|heparin binding|positive regulation of cell population proliferation|regulation of cell shape|cell surface|positive regulation of endothelial cell migration|positive regulation of gene expression|negative regulation of gene expression|regulation of nitric oxide mediated signal transduction|membrane|cytokine-mediated signaling pathway|secretory granule|monocyte differentiation|macrophage differentiation|lung development|positive regulation of cell migration|epithelial cell differentiation|extracellular matrix|post-embryonic camera-type eye development|platelet alpha granule lumen|positive regulation of protein-containing complex assembly|positive regulation of protein autophosphorylation|activation of protein kinase activity|positive regulation of CREB transcription factor activity|positive regulation of peptidyl-serine phosphorylation|tube formation|endothelial cell chemotaxis|cellular response to vascular endothelial growth factor stimulus|lymph vessel morphogenesis|vascular endothelial growth factor receptor-2 signaling pathway|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway|vascular endothelial growth factor signaling pathway|positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway|VEGF-activated neuropilin signaling pathway|chemoattractant activity|eye photoreceptor cell development|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|positive regulation of vascular permeability|surfactant homeostasis|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|vascular endothelial growth factor receptor 1 binding|vascular endothelial growth factor receptor 2 binding|positive regulation of MAP kinase activity|positive regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of cell adhesion|positive regulation of transcription by RNA polymerase II|vascular endothelial growth factor receptor signaling pathway|receptor ligand activity|cell maturation|camera-type eye morphogenesis|cardiac muscle fiber development|branching morphogenesis of an epithelial tube|positive regulation of axon extension involved in axon guidance|artery morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|extracellular matrix binding|positive chemotaxis|positive regulation of positive chemotaxis|induction of positive chemotaxis|positive regulation of cellular component movement|positive regulation of cell division|positive regulation of focal adhesion assembly|primitive erythrocyte differentiation|mammary gland alveolus development|positive regulation of mast cell chemotaxis|cardiac vascular smooth muscle cell development|coronary artery morphogenesis|vascular wound healing|regulation of transcription from RNA polymerase II promoter in response to hypoxia|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to hypoxia|dopaminergic neuron differentiation|commissural neuron axon guidance|positive regulation of protein kinase C signaling|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of branching involved in ureteric bud morphogenesis|regulation of retinal ganglion cell axon guidance|motor neuron migration|cellular stress response to acid chemical|positive regulation of cold-induced thermogenesis|positive regulation of peptidyl-tyrosine autophosphorylation|positive regulation of p38MAPK cascade|positive regulation of trophoblast cell migration|positive regulation of histone deacetylase activity|positive regulation of retinal ganglion cell axon guidance|negative regulation of establishment of endothelial barrier|negative regulation of adherens junction organization|positive regulation of protein kinase D signaling|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|positive regulation of sprouting angiogenesis|negative regulation of blood-brain barrier permeability|negative regulation of cell-cell adhesion mediated by cadherin "hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04066,hsa04151,hsa04370,hsa04510,hsa04926,hsa04933,hsa05163,hsa05165,hsa05167,hsa05200,hsa05205,hsa05206,hsa05211,hsa05212,hsa05219,hsa05323,hsa05418" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|HIF-1 signaling pathway|PI3K-Akt signaling pathway|VEGF signaling pathway|Focal adhesion|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Human cytomegalovirus infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Renal cell carcinoma|Pancreatic cancer|Bladder cancer|Rheumatoid arthritis|Fluid shear stress and atherosclerosis VEGFB 971.8621506 861.4626948 1082.261606 1.256306992 0.329189045 0.181789219 1 25.47073724 31.46360425 7423 vascular endothelial growth factor B "GO:0001666,GO:0001934,GO:0001938,GO:0002040,GO:0002576,GO:0005172,GO:0005515,GO:0005576,GO:0005615,GO:0006493,GO:0008083,GO:0008201,GO:0016020,GO:0031093,GO:0038084,GO:0042056,GO:0042493,GO:0042802,GO:0043183,GO:0045766,GO:0048010,GO:0050918,GO:0050930,GO:0051781,GO:0060048,GO:0060754,GO:0060976" response to hypoxia|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|sprouting angiogenesis|platelet degranulation|vascular endothelial growth factor receptor binding|protein binding|extracellular region|extracellular space|protein O-linked glycosylation|growth factor activity|heparin binding|membrane|platelet alpha granule lumen|vascular endothelial growth factor signaling pathway|chemoattractant activity|response to drug|identical protein binding|vascular endothelial growth factor receptor 1 binding|positive regulation of angiogenesis|vascular endothelial growth factor receptor signaling pathway|positive chemotaxis|induction of positive chemotaxis|positive regulation of cell division|cardiac muscle contraction|positive regulation of mast cell chemotaxis|coronary vasculature development "hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04510,hsa04926,hsa04933,hsa05200" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Pathways in cancer VEGFC 1407.104825 1260.981626 1553.228025 1.231761029 0.300722389 0.209267961 1 29.79029295 36.08048877 7424 vascular endothelial growth factor C "GO:0001666,GO:0001934,GO:0001938,GO:0002040,GO:0002052,GO:0002576,GO:0005172,GO:0005515,GO:0005576,GO:0005615,GO:0006929,GO:0007165,GO:0008083,GO:0008284,GO:0009887,GO:0016020,GO:0016331,GO:0030947,GO:0031093,GO:0031954,GO:0038084,GO:0042056,GO:0042493,GO:0043185,GO:0043536,GO:0045668,GO:0045766,GO:0045776,GO:0045860,GO:0048010,GO:0050714,GO:0050918,GO:0050930,GO:0051781,GO:0060754,GO:1901492,GO:1902462,GO:1990830" response to hypoxia|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|sprouting angiogenesis|positive regulation of neuroblast proliferation|platelet degranulation|vascular endothelial growth factor receptor binding|protein binding|extracellular region|extracellular space|substrate-dependent cell migration|signal transduction|growth factor activity|positive regulation of cell population proliferation|animal organ morphogenesis|membrane|morphogenesis of embryonic epithelium|regulation of vascular endothelial growth factor receptor signaling pathway|platelet alpha granule lumen|positive regulation of protein autophosphorylation|vascular endothelial growth factor signaling pathway|chemoattractant activity|response to drug|vascular endothelial growth factor receptor 3 binding|positive regulation of blood vessel endothelial cell migration|negative regulation of osteoblast differentiation|positive regulation of angiogenesis|negative regulation of blood pressure|positive regulation of protein kinase activity|vascular endothelial growth factor receptor signaling pathway|positive regulation of protein secretion|positive chemotaxis|induction of positive chemotaxis|positive regulation of cell division|positive regulation of mast cell chemotaxis|positive regulation of lymphangiogenesis|positive regulation of mesenchymal stem cell proliferation|cellular response to leukemia inhibitory factor "hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04510,hsa04668,hsa04926,hsa04933,hsa05200" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|TNF signaling pathway|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Pathways in cancer VEPH1 802.461543 754.3000649 850.6230211 1.127698459 0.17338135 0.492489055 1 6.852018403 7.597709539 79674 ventricular zone expressed PH domain containing 1 "GO:0005515,GO:0005886,GO:0009966,GO:0010314,GO:0030512,GO:0060392" protein binding|plasma membrane|regulation of signal transduction|phosphatidylinositol-5-phosphate binding|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of SMAD protein signal transduction VEZF1 2010.848661 2210.879501 1810.817821 0.819048628 -0.287978986 0.223565743 1 24.24297833 19.52391188 7716 vascular endothelial zinc finger 1 "GO:0000977,GO:0000981,GO:0001228,GO:0001525,GO:0001885,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006968,GO:0045603,GO:0045944,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|endothelial cell development|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cellular defense response|positive regulation of endothelial cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 VEZT 1548.070846 1567.903721 1528.23797 0.974701411 -0.036967761 0.879316762 1 12.74967849 12.21917843 55591 "vezatin, adherens junctions transmembrane protein" "GO:0001669,GO:0002142,GO:0005654,GO:0005829,GO:0005912,GO:0016021,GO:0017022,GO:0060171,GO:0098609" acrosomal vesicle|stereocilia ankle link complex|nucleoplasm|cytosol|adherens junction|integral component of membrane|myosin binding|stereocilium membrane|cell-cell adhesion VGF 36.8308972 33.29324424 40.36855015 1.212514763 0.278002313 0.707736953 1 0.579895318 0.691365679 7425 VGF nerve growth factor inducible "GO:0001541,GO:0002021,GO:0003674,GO:0005179,GO:0005184,GO:0005615,GO:0005788,GO:0005794,GO:0006091,GO:0007165,GO:0008083,GO:0009409,GO:0019953,GO:0030073,GO:0030133,GO:0031410,GO:0032868,GO:0033500,GO:0042593,GO:0042742,GO:0043231,GO:0043687,GO:0044267,GO:0048167,GO:0051591" ovarian follicle development|response to dietary excess|molecular_function|hormone activity|neuropeptide hormone activity|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|generation of precursor metabolites and energy|signal transduction|growth factor activity|response to cold|sexual reproduction|insulin secretion|transport vesicle|cytoplasmic vesicle|response to insulin|carbohydrate homeostasis|glucose homeostasis|defense response to bacterium|intracellular membrane-bounded organelle|post-translational protein modification|cellular protein metabolic process|regulation of synaptic plasticity|response to cAMP VGLL3 718.9554457 668.9861265 768.9247648 1.149388207 0.200866153 0.43284401 1 3.077806899 3.478398094 389136 vestigial like family member 3 "GO:0005634,GO:0006357" nucleus|regulation of transcription by RNA polymerase II VGLL4 975.5224921 1020.646019 930.3989654 0.911578499 -0.133561199 0.589811954 1 10.32802468 9.257261215 9686 vestigial like family member 4 "GO:0001223,GO:0005515,GO:0005634,GO:0030178,GO:0030308,GO:0035331,GO:0045892,GO:0060044,GO:1903364" "transcription coactivator binding|protein binding|nucleus|negative regulation of Wnt signaling pathway|negative regulation of cell growth|negative regulation of hippo signaling|negative regulation of transcription, DNA-templated|negative regulation of cardiac muscle cell proliferation|positive regulation of cellular protein catabolic process" VHL 2223.87181 2491.791249 1955.95237 0.784958359 -0.349311971 0.139523399 1 28.45759025 21.96422678 7428 von Hippel-Lindau tumor suppressor "GO:0000122,GO:0000902,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005783,GO:0005829,GO:0006355,GO:0006508,GO:0008134,GO:0008285,GO:0010629,GO:0016020,GO:0016567,GO:0019899,GO:0043066,GO:0043687,GO:0045597,GO:0045893,GO:0046426,GO:0050821,GO:0061418,GO:0061428,GO:1990756" "negative regulation of transcription by RNA polymerase II|cell morphogenesis|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|mitochondrion|endoplasmic reticulum|cytosol|regulation of transcription, DNA-templated|proteolysis|transcription factor binding|negative regulation of cell population proliferation|negative regulation of gene expression|membrane|protein ubiquitination|enzyme binding|negative regulation of apoptotic process|post-translational protein modification|positive regulation of cell differentiation|positive regulation of transcription, DNA-templated|negative regulation of receptor signaling pathway via JAK-STAT|protein stabilization|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of transcription from RNA polymerase II promoter in response to hypoxia|ubiquitin ligase-substrate adaptor activity" "hsa04066,hsa04120,hsa05200,hsa05211" HIF-1 signaling pathway|Ubiquitin mediated proteolysis|Pathways in cancer|Renal cell carcinoma VILL 124.057701 127.9709076 120.1444945 0.938842248 -0.091045331 0.851218286 1 2.098823644 1.937491255 50853 villin like "GO:0005200,GO:0005546,GO:0005737,GO:0008154,GO:0015629,GO:0051014,GO:0051015,GO:0051016" "structural constituent of cytoskeleton|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|actin polymerization or depolymerization|actin cytoskeleton|actin filament severing|actin filament binding|barbed-end actin filament capping" VIM 81280.47676 73843.37532 88717.57821 1.201429076 0.264751485 0.471264749 1 1827.021429 2158.305702 7431 vimentin "GO:0003725,GO:0005200,GO:0005212,GO:0005515,GO:0005737,GO:0005777,GO:0005829,GO:0005844,GO:0005856,GO:0005882,GO:0005886,GO:0005925,GO:0010977,GO:0014002,GO:0016032,GO:0016363,GO:0019221,GO:0019904,GO:0030049,GO:0031252,GO:0032967,GO:0042802,GO:0043005,GO:0043488,GO:0045109,GO:0045111,GO:0045335,GO:0045727,GO:0060020,GO:0060395,GO:0070062,GO:0070307,GO:0071222,GO:0071225,GO:0071346,GO:0097110,GO:1990254,GO:1990904" double-stranded RNA binding|structural constituent of cytoskeleton|structural constituent of eye lens|protein binding|cytoplasm|peroxisome|cytosol|polysome|cytoskeleton|intermediate filament|plasma membrane|focal adhesion|negative regulation of neuron projection development|astrocyte development|viral process|nuclear matrix|cytokine-mediated signaling pathway|protein domain specific binding|muscle filament sliding|cell leading edge|positive regulation of collagen biosynthetic process|identical protein binding|neuron projection|regulation of mRNA stability|intermediate filament organization|intermediate filament cytoskeleton|phagocytic vesicle|positive regulation of translation|Bergmann glial cell differentiation|SMAD protein signal transduction|extracellular exosome|lens fiber cell development|cellular response to lipopolysaccharide|cellular response to muramyl dipeptide|cellular response to interferon-gamma|scaffold protein binding|keratin filament binding|ribonucleoprotein complex "hsa05169,hsa05206" Epstein-Barr virus infection|MicroRNAs in cancer VIPAS39 620.78356 703.3197847 538.2473354 0.765295314 -0.385911529 0.13957254 1 11.23462564 8.453933709 63894 "VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog" "GO:0005515,GO:0005737,GO:0005769,GO:0005770,GO:0005794,GO:0006886,GO:0007034,GO:0007283,GO:0008333,GO:0017185,GO:0030154,GO:0030897,GO:0032963,GO:0044877,GO:0055037,GO:0097352" protein binding|cytoplasm|early endosome|late endosome|Golgi apparatus|intracellular protein transport|vacuolar transport|spermatogenesis|endosome to lysosome transport|peptidyl-lysine hydroxylation|cell differentiation|HOPS complex|collagen metabolic process|protein-containing complex binding|recycling endosome|autophagosome maturation VIRMA 2471.682084 2411.67938 2531.684788 1.0497601 0.070059669 0.768209486 1 19.09597864 19.7107505 25962 vir like m6A methyltransferase associated "GO:0003723,GO:0005515,GO:0005654,GO:0005829,GO:0006397,GO:0007275,GO:0008380,GO:0016604,GO:0016607,GO:0036396,GO:0080009,GO:0110104" RNA binding|protein binding|nucleoplasm|cytosol|mRNA processing|multicellular organism development|RNA splicing|nuclear body|nuclear speck|RNA N6-methyladenosine methyltransferase complex|mRNA methylation|mRNA alternative polyadenylation VKORC1 1793.367561 1762.461117 1824.274004 1.035071915 0.049731008 0.835960289 1 101.7957906 103.6028073 79001 vitamin K epoxide reductase complex subunit 1 "GO:0005515,GO:0005783,GO:0005789,GO:0007596,GO:0010243,GO:0014070,GO:0016021,GO:0017144,GO:0017187,GO:0030193,GO:0042373,GO:0046677,GO:0047057,GO:0047058,GO:0048038,GO:0055114,GO:0060348" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|blood coagulation|response to organonitrogen compound|response to organic cyclic compound|integral component of membrane|drug metabolic process|peptidyl-glutamic acid carboxylation|regulation of blood coagulation|vitamin K metabolic process|response to antibiotic|vitamin-K-epoxide reductase (warfarin-sensitive) activity|vitamin-K-epoxide reductase (warfarin-insensitive) activity|quinone binding|oxidation-reduction process|bone development hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis VKORC1L1 1043.120441 1028.96933 1057.271552 1.027505408 0.039145988 0.87681536 1 8.844290864 8.935488742 154807 vitamin K epoxide reductase complex subunit 1 like 1 "GO:0005515,GO:0005783,GO:0005789,GO:0016021,GO:0017187,GO:0034599,GO:0042373,GO:0047057,GO:0048038,GO:0055114" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|peptidyl-glutamic acid carboxylation|cellular response to oxidative stress|vitamin K metabolic process|vitamin-K-epoxide reductase (warfarin-sensitive) activity|quinone binding|oxidation-reduction process hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis VLDLR 603.0027892 602.399638 603.6059404 1.002002495 0.002886101 0.998519233 1 3.489521493 3.437999896 7436 very low density lipoprotein receptor "GO:0005041,GO:0005509,GO:0005515,GO:0005765,GO:0005886,GO:0005905,GO:0006869,GO:0006898,GO:0007165,GO:0007399,GO:0007411,GO:0007613,GO:0008203,GO:0016020,GO:0016021,GO:0021517,GO:0030229,GO:0032802,GO:0034185,GO:0034189,GO:0034361,GO:0034436,GO:0034447,GO:0038024,GO:0038025,GO:0038026,GO:0043235,GO:0045860,GO:0048306,GO:0048813,GO:1900006" low-density lipoprotein particle receptor activity|calcium ion binding|protein binding|lysosomal membrane|plasma membrane|clathrin-coated pit|lipid transport|receptor-mediated endocytosis|signal transduction|nervous system development|axon guidance|memory|cholesterol metabolic process|membrane|integral component of membrane|ventral spinal cord development|very-low-density lipoprotein particle receptor activity|low-density lipoprotein particle receptor catabolic process|apolipoprotein binding|very-low-density lipoprotein particle binding|very-low-density lipoprotein particle|glycoprotein transport|very-low-density lipoprotein particle clearance|cargo receptor activity|reelin receptor activity|reelin-mediated signaling pathway|receptor complex|positive regulation of protein kinase activity|calcium-dependent protein binding|dendrite morphogenesis|positive regulation of dendrite development hsa05017 Spinocerebellar ataxia VMA21 1894.507203 1717.72332 2071.291085 1.205835108 0.270032639 0.2543323 1 17.70408199 20.99097034 203547 vacuolar ATPase assembly factor VMA21 "GO:0005515,GO:0005764,GO:0005773,GO:0005789,GO:0012507,GO:0016021,GO:0033116,GO:0043462,GO:0070072" protein binding|lysosome|vacuole|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|integral component of membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly VMAC 56.04395548 58.26317743 53.82473354 0.923820772 -0.11431511 0.872251291 1 1.388124418 1.260919309 400673 vimentin type intermediate filament associated coiled-coil protein "GO:0005515,GO:0005737,GO:0045098" protein binding|cytoplasm|type III intermediate filament VMO1 35.58730808 38.49531366 32.6793025 0.848916385 -0.236305634 0.760493828 1 2.798942968 2.336308257 284013 vitelline membrane outer layer 1 homolog "GO:0003674,GO:0008150,GO:0070062" molecular_function|biological_process|extracellular exosome VMP1 6509.615146 5997.986033 7021.244259 1.170600301 0.227248555 0.350368256 1 85.93328611 98.91023412 81671 vacuole membrane protein 1 "GO:0000045,GO:0000407,GO:0000421,GO:0005515,GO:0005730,GO:0005783,GO:0005886,GO:0006914,GO:0007030,GO:0007566,GO:0012505,GO:0016020,GO:0016021,GO:0033116,GO:0034329,GO:0098609" autophagosome assembly|phagophore assembly site|autophagosome membrane|protein binding|nucleolus|endoplasmic reticulum|plasma membrane|autophagy|Golgi organization|embryo implantation|endomembrane system|membrane|integral component of membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|cell junction assembly|cell-cell adhesion hsa04140 Autophagy - animal VN1R1 17.7367258 11.44455271 24.0288989 2.099592663 1.070109461 0.240135862 1 0.259793596 0.536333181 57191 vomeronasal 1 receptor 1 "GO:0005886,GO:0007186,GO:0008150,GO:0016021,GO:0016503,GO:0019236" plasma membrane|G protein-coupled receptor signaling pathway|biological_process|integral component of membrane|pheromone receptor activity|response to pheromone VNN1 19.25268725 26.01034707 12.49502743 0.480386801 -1.057731582 0.22603821 1 0.360271066 0.170173382 8876 vanin 1 "GO:0002526,GO:0002544,GO:0005576,GO:0005886,GO:0006954,GO:0006979,GO:0015939,GO:0016021,GO:0017159,GO:0031225,GO:0033089,GO:0035577,GO:0043312,GO:0045087,GO:0098609,GO:1902176" acute inflammatory response|chronic inflammatory response|extracellular region|plasma membrane|inflammatory response|response to oxidative stress|pantothenate metabolic process|integral component of membrane|pantetheine hydrolase activity|anchored component of membrane|positive regulation of T cell differentiation in thymus|azurophil granule membrane|neutrophil degranulation|innate immune response|cell-cell adhesion|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway hsa00770 Pantothenate and CoA biosynthesis VNN2 6.123596406 9.363724944 2.883467868 0.307940257 -1.699277611 0.271781165 1 0.158844498 0.048096096 8875 vanin 2 "GO:0005515,GO:0005576,GO:0005886,GO:0015939,GO:0017159,GO:0031225" protein binding|extracellular region|plasma membrane|pantothenate metabolic process|pantetheine hydrolase activity|anchored component of membrane hsa00770 Pantothenate and CoA biosynthesis VNN3 2.041198802 3.121241648 0.961155956 0.307940257 -1.699277611 0.684095484 1 0.095458413 0.028903594 55350 vanin 3 "GO:0005575,GO:0005576,GO:0005886,GO:0008150,GO:0015939,GO:0017159" cellular_component|extracellular region|plasma membrane|biological_process|pantothenate metabolic process|pantetheine hydrolase activity hsa00770 Pantothenate and CoA biosynthesis VOPP1 2368.606882 2191.111637 2546.102127 1.162013877 0.216627297 0.35963538 1 20.40760924 23.31710471 81552 VOPP1 WW domain binding protein "GO:0005768,GO:0030659,GO:0031301" endosome|cytoplasmic vesicle membrane|integral component of organelle membrane VPS11 1036.24328 1100.757888 971.7286715 0.882781475 -0.17987174 0.464083708 1 17.17200391 14.90545947 55823 VPS11 core subunit of CORVET and HOPS complexes "GO:0000166,GO:0005515,GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005776,GO:0006886,GO:0006904,GO:0006914,GO:0007032,GO:0007033,GO:0008333,GO:0016567,GO:0019904,GO:0019905,GO:0030136,GO:0030139,GO:0030674,GO:0030897,GO:0031647,GO:0031902,GO:0033147,GO:0034058,GO:0035542,GO:0046872,GO:0061630,GO:1902115,GO:1903364,GO:1903955,GO:2000643" nucleotide binding|protein binding|lysosome|lysosomal membrane|endosome|early endosome|late endosome|autophagosome|intracellular protein transport|vesicle docking involved in exocytosis|autophagy|endosome organization|vacuole organization|endosome to lysosome transport|protein ubiquitination|protein domain specific binding|syntaxin binding|clathrin-coated vesicle|endocytic vesicle|protein-macromolecule adaptor activity|HOPS complex|regulation of protein stability|late endosome membrane|negative regulation of intracellular estrogen receptor signaling pathway|endosomal vesicle fusion|regulation of SNARE complex assembly|metal ion binding|ubiquitin protein ligase activity|regulation of organelle assembly|positive regulation of cellular protein catabolic process|positive regulation of protein targeting to mitochondrion|positive regulation of early endosome to late endosome transport hsa05132 Salmonella infection VPS13A 2473.975533 2484.508352 2463.442715 0.991521205 -0.012284468 0.960405355 1 8.005895689 7.805183406 23230 vacuolar protein sorting 13 homolog A "GO:0005515,GO:0005741,GO:0005765,GO:0005789,GO:0005794,GO:0005811,GO:0005829,GO:0006623,GO:0006895,GO:0006914,GO:0007399,GO:0007626,GO:0008104,GO:0010008,GO:0019898,GO:0030317,GO:0030382,GO:0031966,GO:0035176,GO:0045053,GO:0097225,GO:0099013,GO:1905146" protein binding|mitochondrial outer membrane|lysosomal membrane|endoplasmic reticulum membrane|Golgi apparatus|lipid droplet|cytosol|protein targeting to vacuole|Golgi to endosome transport|autophagy|nervous system development|locomotory behavior|protein localization|endosome membrane|extrinsic component of membrane|flagellated sperm motility|sperm mitochondrion organization|mitochondrial membrane|social behavior|protein retention in Golgi apparatus|sperm midpiece|neuronal dense core vesicle lumen|lysosomal protein catabolic process VPS13B 1282.252702 1414.96288 1149.542523 0.812418855 -0.299704372 0.213469978 1 5.148913701 4.113076486 157680 vacuolar protein sorting 13 homolog B GO:0015031 protein transport VPS13C 1222.820163 1318.204389 1127.435936 0.855281583 -0.225528621 0.351343547 1 4.013357607 3.375111757 54832 vacuolar protein sorting 13 homolog C "GO:0005737,GO:0005741,GO:0005829,GO:0006623,GO:0006895,GO:0007005,GO:0019898,GO:0032127,GO:0032868,GO:0045053,GO:0070062,GO:1905090" cytoplasm|mitochondrial outer membrane|cytosol|protein targeting to vacuole|Golgi to endosome transport|mitochondrion organization|extrinsic component of membrane|dense core granule membrane|response to insulin|protein retention in Golgi apparatus|extracellular exosome|negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization VPS13D 2174.006171 2406.477311 1941.535031 0.806795486 -0.309725083 0.190190041 1 7.851639735 6.228665414 55187 vacuolar protein sorting 13 homolog D "GO:0006623,GO:0007005,GO:0019898,GO:0045053,GO:0070062,GO:1901526" protein targeting to vacuole|mitochondrion organization|extrinsic component of membrane|protein retention in Golgi apparatus|extracellular exosome|positive regulation of mitophagy VPS16 531.7835137 536.8535634 526.7134639 0.981111982 -0.027510282 0.926025556 1 10.58009158 10.20655512 64601 VPS16 core subunit of CORVET and HOPS complexes "GO:0003779,GO:0005515,GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005776,GO:0006886,GO:0007033,GO:0008333,GO:0016197,GO:0030136,GO:0030424,GO:0030897,GO:0031902,GO:0032889,GO:0035542,GO:0043025,GO:0051015,GO:0055037,GO:0097352" "actin binding|protein binding|lysosome|lysosomal membrane|endosome|early endosome|late endosome|autophagosome|intracellular protein transport|vacuole organization|endosome to lysosome transport|endosomal transport|clathrin-coated vesicle|axon|HOPS complex|late endosome membrane|regulation of vacuole fusion, non-autophagic|regulation of SNARE complex assembly|neuronal cell body|actin filament binding|recycling endosome|autophagosome maturation" hsa05132 Salmonella infection VPS18 551.0311705 575.3488771 526.7134639 0.915467962 -0.127418697 0.63787096 1 7.643841704 6.880595284 57617 VPS18 core subunit of CORVET and HOPS complexes "GO:0003779,GO:0005515,GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005776,GO:0005884,GO:0006886,GO:0006904,GO:0006914,GO:0007032,GO:0007033,GO:0007040,GO:0008333,GO:0016567,GO:0019905,GO:0030123,GO:0030136,GO:0030674,GO:0030897,GO:0031902,GO:0033147,GO:0033263,GO:0035542,GO:0046718,GO:0046872,GO:0061630,GO:0098793,GO:0098978,GO:2000300" actin binding|protein binding|lysosome|lysosomal membrane|endosome|early endosome|late endosome|autophagosome|actin filament|intracellular protein transport|vesicle docking involved in exocytosis|autophagy|endosome organization|vacuole organization|lysosome organization|endosome to lysosome transport|protein ubiquitination|syntaxin binding|AP-3 adaptor complex|clathrin-coated vesicle|protein-macromolecule adaptor activity|HOPS complex|late endosome membrane|negative regulation of intracellular estrogen receptor signaling pathway|CORVET complex|regulation of SNARE complex assembly|viral entry into host cell|metal ion binding|ubiquitin protein ligase activity|presynapse|glutamatergic synapse|regulation of synaptic vesicle exocytosis hsa05132 Salmonella infection VPS25 1674.001169 1719.804148 1628.198189 0.946734657 -0.07896796 0.741407626 1 84.35917878 78.52931285 84313 vacuolar protein sorting 25 homolog "GO:0000814,GO:0005198,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007175,GO:0010008,GO:0016197,GO:0016236,GO:0036258,GO:0042803,GO:0043328,GO:0047485,GO:0070062" ESCRT II complex|structural molecule activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|negative regulation of epidermal growth factor-activated receptor activity|endosome membrane|endosomal transport|macroautophagy|multivesicular body assembly|protein homodimerization activity|protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein N-terminus binding|extracellular exosome hsa04144 Endocytosis VPS26A 3763.571498 3764.217427 3762.925568 0.999656805 -0.00049521 0.999621295 1 46.68588561 45.8889063 9559 "VPS26, retromer complex component A" "GO:0005515,GO:0005764,GO:0005768,GO:0005769,GO:0005829,GO:0006886,GO:0010008,GO:0016055,GO:0016241,GO:0030904,GO:0030906,GO:0031982,GO:0042147,GO:0097422,GO:1990126" "protein binding|lysosome|endosome|early endosome|cytosol|intracellular protein transport|endosome membrane|Wnt signaling pathway|regulation of macroautophagy|retromer complex|retromer, cargo-selective complex|vesicle|retrograde transport, endosome to Golgi|tubular endosome|retrograde transport, endosome to plasma membrane" hsa04144 Endocytosis VPS26B 1048.906884 1079.94961 1017.864157 0.942510787 -0.085418964 0.729950703 1 13.45353077 12.46791362 112936 "VPS26, retromer complex component B" "GO:0005515,GO:0005768,GO:0005769,GO:0005770,GO:0005829,GO:0006886,GO:0016241,GO:0030904,GO:0030906,GO:0042147,GO:0045335,GO:0071346" "protein binding|endosome|early endosome|late endosome|cytosol|intracellular protein transport|regulation of macroautophagy|retromer complex|retromer, cargo-selective complex|retrograde transport, endosome to Golgi|phagocytic vesicle|cellular response to interferon-gamma" hsa04144 Endocytosis VPS26C 1183.488839 1030.009744 1336.967935 1.298014842 0.37630688 0.120592879 1 17.97571189 22.942299 10311 VPS26 endosomal protein sorting factor C "GO:0003674,GO:0005515,GO:0005634,GO:0005768,GO:0006886,GO:0032456,GO:1990126" "molecular_function|protein binding|nucleus|endosome|intracellular protein transport|endocytic recycling|retrograde transport, endosome to plasma membrane" VPS28 1804.791992 1835.290089 1774.293895 0.966764821 -0.048763118 0.839101724 1 82.86468606 78.77011995 51160 VPS28 subunit of ESCRT-I "GO:0000813,GO:0005515,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0010008,GO:0016197,GO:0016236,GO:0019058,GO:0031397,GO:0031902,GO:0036258,GO:0039702,GO:0043130,GO:0043162,GO:0043328,GO:0043657,GO:0044877,GO:0045732,GO:0070062,GO:0075733,GO:2000397" ESCRT I complex|protein binding|cytoplasm|endosome|early endosome|cytosol|plasma membrane|endosome membrane|endosomal transport|macroautophagy|viral life cycle|negative regulation of protein ubiquitination|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|host cell|protein-containing complex binding|positive regulation of protein catabolic process|extracellular exosome|intracellular transport of virus|positive regulation of ubiquitin-dependent endocytosis hsa04144 Endocytosis VPS29 2075.585106 1866.502505 2284.667707 1.224036775 0.291646903 0.217628639 1 54.61173697 65.72818416 51699 VPS29 retromer complex component "GO:0005515,GO:0005768,GO:0005769,GO:0005770,GO:0005829,GO:0006886,GO:0010008,GO:0010506,GO:0016032,GO:0016055,GO:0030904,GO:0030906,GO:0032456,GO:0042147,GO:0043231,GO:0046872,GO:1990126" "protein binding|endosome|early endosome|late endosome|cytosol|intracellular protein transport|endosome membrane|regulation of autophagy|viral process|Wnt signaling pathway|retromer complex|retromer, cargo-selective complex|endocytic recycling|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|metal ion binding|retrograde transport, endosome to plasma membrane" hsa04144 Endocytosis VPS33A 870.0884454 889.5538697 850.6230211 0.956235536 -0.064562075 0.799495724 1 8.549226561 8.038275444 65082 VPS33A core subunit of CORVET and HOPS complexes "GO:0005515,GO:0005764,GO:0005765,GO:0005769,GO:0005770,GO:0005776,GO:0006886,GO:0006904,GO:0008333,GO:0016192,GO:0030123,GO:0030136,GO:0030220,GO:0030897,GO:0031902,GO:0032400,GO:0032418,GO:0033263,GO:0035751,GO:0048070,GO:0048471,GO:0071439,GO:0097352" protein binding|lysosome|lysosomal membrane|early endosome|late endosome|autophagosome|intracellular protein transport|vesicle docking involved in exocytosis|endosome to lysosome transport|vesicle-mediated transport|AP-3 adaptor complex|clathrin-coated vesicle|platelet formation|HOPS complex|late endosome membrane|melanosome localization|lysosome localization|CORVET complex|regulation of lysosomal lumen pH|regulation of developmental pigmentation|perinuclear region of cytoplasm|clathrin complex|autophagosome maturation hsa05132 Salmonella infection VPS33B 500.4125813 470.267075 530.5580877 1.128205898 0.174030384 0.527443544 1 8.815345794 9.779100226 26276 VPS33B late endosome and lysosome associated "GO:0005515,GO:0005737,GO:0005764,GO:0005765,GO:0005770,GO:0005794,GO:0006886,GO:0006904,GO:0007032,GO:0008333,GO:0015031,GO:0016192,GO:0017185,GO:0030136,GO:0030897,GO:0031091,GO:0031901,GO:0031902,GO:0032400,GO:0032418,GO:0032963,GO:0033263,GO:0044877,GO:0048471,GO:0055037,GO:0061025,GO:0070889,GO:0097352" protein binding|cytoplasm|lysosome|lysosomal membrane|late endosome|Golgi apparatus|intracellular protein transport|vesicle docking involved in exocytosis|endosome organization|endosome to lysosome transport|protein transport|vesicle-mediated transport|peptidyl-lysine hydroxylation|clathrin-coated vesicle|HOPS complex|platelet alpha granule|early endosome membrane|late endosome membrane|melanosome localization|lysosome localization|collagen metabolic process|CORVET complex|protein-containing complex binding|perinuclear region of cytoplasm|recycling endosome|membrane fusion|platelet alpha granule organization|autophagosome maturation VPS35 4788.282135 4663.135022 4913.429247 1.053675097 0.075430078 0.753483857 1 32.70639317 33.88523857 55737 VPS35 retromer complex component "GO:0005515,GO:0005739,GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005829,GO:0006886,GO:0010008,GO:0010628,GO:0010821,GO:0016032,GO:0016055,GO:0016241,GO:0030904,GO:0030906,GO:0031647,GO:0031748,GO:0032268,GO:0036010,GO:0042147,GO:0043653,GO:0045056,GO:0050728,GO:0060161,GO:0060548,GO:0070062,GO:0090141,GO:0097422,GO:0099073,GO:0099074,GO:0099639,GO:1901215,GO:1902823,GO:1902950,GO:1903364,GO:1905606,GO:1990126,GO:2000331" "protein binding|mitochondrion|lysosome|lysosomal membrane|endosome|early endosome|late endosome|cytosol|intracellular protein transport|endosome membrane|positive regulation of gene expression|regulation of mitochondrion organization|viral process|Wnt signaling pathway|regulation of macroautophagy|retromer complex|retromer, cargo-selective complex|regulation of protein stability|D1 dopamine receptor binding|regulation of cellular protein metabolic process|protein localization to endosome|retrograde transport, endosome to Golgi|mitochondrial fragmentation involved in apoptotic process|transcytosis|negative regulation of inflammatory response|positive regulation of dopamine receptor signaling pathway|negative regulation of cell death|extracellular exosome|positive regulation of mitochondrial fission|tubular endosome|mitochondrion-derived vesicle|mitochondrion to lysosome transport|neurotransmitter receptor transport, endosome to plasma membrane|negative regulation of neuron death|negative regulation of late endosome to lysosome transport|regulation of dendritic spine maintenance|positive regulation of cellular protein catabolic process|regulation of presynapse assembly|retrograde transport, endosome to plasma membrane|regulation of terminal button organization" hsa04144 Endocytosis VPS35L 577.888817 611.763363 544.0142711 0.889256049 -0.169329212 0.525374679 1 8.748308229 7.649306848 57020 VPS35 endosomal protein sorting factor like "GO:0005515,GO:0005768,GO:0005886,GO:0006893,GO:0015031,GO:0016021,GO:0032456,GO:0043312,GO:0101003,GO:1990126" "protein binding|endosome|plasma membrane|Golgi to plasma membrane transport|protein transport|integral component of membrane|endocytic recycling|neutrophil degranulation|ficolin-1-rich granule membrane|retrograde transport, endosome to plasma membrane" VPS36 653.3144075 674.188196 632.440619 0.938077265 -0.092221339 0.726158352 1 7.592358074 7.003037817 51028 vacuolar protein sorting 36 homolog "GO:0000814,GO:0005515,GO:0005634,GO:0005768,GO:0005829,GO:0008022,GO:0016197,GO:0016236,GO:0031902,GO:0032266,GO:0036258,GO:0043130,GO:0043328,GO:0070062" ESCRT II complex|protein binding|nucleus|endosome|cytosol|protein C-terminus binding|endosomal transport|macroautophagy|late endosome membrane|phosphatidylinositol-3-phosphate binding|multivesicular body assembly|ubiquitin binding|protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|extracellular exosome hsa04144 Endocytosis VPS37A 870.5746681 776.1487565 965.0005798 1.243319108 0.314196624 0.207577353 1 4.165908944 5.092881369 137492 VPS37A subunit of ESCRT-I "GO:0000813,GO:0005515,GO:0005654,GO:0005813,GO:0005829,GO:0006612,GO:0006623,GO:0010008,GO:0016197,GO:0016236,GO:0019058,GO:0031902,GO:0036258,GO:0039702,GO:0043162,GO:0043231,GO:0043657,GO:0075733" ESCRT I complex|protein binding|nucleoplasm|centrosome|cytosol|protein targeting to membrane|protein targeting to vacuole|endosome membrane|endosomal transport|macroautophagy|viral life cycle|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|intracellular membrane-bounded organelle|host cell|intracellular transport of virus hsa04144 Endocytosis VPS37B 1127.235449 1193.354723 1061.116175 0.889187561 -0.169440329 0.487383303 1 10.34050143 9.040785304 79720 VPS37B subunit of ESCRT-I "GO:0000813,GO:0005515,GO:0005737,GO:0005768,GO:0005886,GO:0006612,GO:0006623,GO:0010008,GO:0016197,GO:0016236,GO:0019058,GO:0030496,GO:0031902,GO:0036258,GO:0039702,GO:0043162,GO:0043231,GO:0043657,GO:0048306,GO:0070062,GO:0075733,GO:1902188,GO:1903774" ESCRT I complex|protein binding|cytoplasm|endosome|plasma membrane|protein targeting to membrane|protein targeting to vacuole|endosome membrane|endosomal transport|macroautophagy|viral life cycle|midbody|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|intracellular membrane-bounded organelle|host cell|calcium-dependent protein binding|extracellular exosome|intracellular transport of virus|positive regulation of viral release from host cell|positive regulation of viral budding via host ESCRT complex hsa04144 Endocytosis VPS37C 422.4501228 442.1759001 402.7243456 0.910778596 -0.134827707 0.641183173 1 8.176755061 7.322594463 55048 VPS37C subunit of ESCRT-I "GO:0000813,GO:0005515,GO:0006612,GO:0006623,GO:0010008,GO:0016197,GO:0016236,GO:0019058,GO:0031902,GO:0036258,GO:0039702,GO:0043162,GO:0043231,GO:0043657,GO:0048306,GO:0070062,GO:0075733" ESCRT I complex|protein binding|protein targeting to membrane|protein targeting to vacuole|endosome membrane|endosomal transport|macroautophagy|viral life cycle|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|intracellular membrane-bounded organelle|host cell|calcium-dependent protein binding|extracellular exosome|intracellular transport of virus hsa04144 Endocytosis VPS37D 92.80062517 76.99062732 108.610623 1.410699287 0.496410487 0.304863398 1 1.993618766 2.765334923 155382 VPS37D subunit of ESCRT-I "GO:0000813,GO:0005515,GO:0006612,GO:0006623,GO:0010008,GO:0016197,GO:0016236,GO:0019058,GO:0031902,GO:0036258,GO:0039702,GO:0043162,GO:0043231,GO:0043657,GO:0070062,GO:0075733" ESCRT I complex|protein binding|protein targeting to membrane|protein targeting to vacuole|endosome membrane|endosomal transport|macroautophagy|viral life cycle|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|intracellular membrane-bounded organelle|host cell|extracellular exosome|intracellular transport of virus hsa04144 Endocytosis VPS39 1235.721541 1303.638595 1167.804487 0.895803861 -0.158745211 0.51227618 1 12.70503941 11.190774 23339 VPS39 subunit of HOPS complex "GO:0005515,GO:0005737,GO:0005765,GO:0006886,GO:0006914,GO:0008333,GO:0016020,GO:0030123,GO:0030897,GO:0031902,GO:0034058,GO:1902774,GO:1990126" "protein binding|cytoplasm|lysosomal membrane|intracellular protein transport|autophagy|endosome to lysosome transport|membrane|AP-3 adaptor complex|HOPS complex|late endosome membrane|endosomal vesicle fusion|late endosome to lysosome transport|retrograde transport, endosome to plasma membrane" hsa05132 Salmonella infection VPS41 1237.341912 1257.860384 1216.82344 0.967375597 -0.04785195 0.846010779 1 11.19201348 10.64570754 27072 VPS41 subunit of HOPS complex "GO:0005515,GO:0005765,GO:0005769,GO:0005770,GO:0005794,GO:0005798,GO:0006623,GO:0008017,GO:0008333,GO:0009267,GO:0010008,GO:0015630,GO:0016236,GO:0030123,GO:0030136,GO:0030897,GO:0031902,GO:0034058,GO:0042802,GO:0043621,GO:0045055,GO:0046872,GO:0071439,GO:1902774" protein binding|lysosomal membrane|early endosome|late endosome|Golgi apparatus|Golgi-associated vesicle|protein targeting to vacuole|microtubule binding|endosome to lysosome transport|cellular response to starvation|endosome membrane|microtubule cytoskeleton|macroautophagy|AP-3 adaptor complex|clathrin-coated vesicle|HOPS complex|late endosome membrane|endosomal vesicle fusion|identical protein binding|protein self-association|regulated exocytosis|metal ion binding|clathrin complex|late endosome to lysosome transport hsa05132 Salmonella infection VPS45 676.3324606 698.1177153 654.547206 0.937588592 -0.092973078 0.722310532 1 13.45027414 12.39979855 11311 vacuolar protein sorting 45 homolog "GO:0000139,GO:0003674,GO:0005515,GO:0005575,GO:0005794,GO:0006886,GO:0006904,GO:0007596,GO:0010008,GO:0016021,GO:0016192" Golgi membrane|molecular_function|protein binding|cellular_component|Golgi apparatus|intracellular protein transport|vesicle docking involved in exocytosis|blood coagulation|endosome membrane|integral component of membrane|vesicle-mediated transport hsa04144 Endocytosis VPS4A 2248.309517 2073.544868 2423.074165 1.168566064 0.224739298 0.341959575 1 26.9511151 30.9671464 27183 vacuolar protein sorting 4 homolog A "GO:0000916,GO:0000922,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005764,GO:0005768,GO:0005769,GO:0005770,GO:0005774,GO:0005813,GO:0005829,GO:0005886,GO:0006622,GO:0006900,GO:0006997,GO:0006998,GO:0007033,GO:0007080,GO:0008022,GO:0009838,GO:0010008,GO:0016192,GO:0016197,GO:0016236,GO:0016887,GO:0019058,GO:0019076,GO:0019904,GO:0030496,GO:0031468,GO:0031902,GO:0032367,GO:0032466,GO:0032880,GO:0034058,GO:0036258,GO:0039702,GO:0043162,GO:0044877,GO:0044878,GO:0048471,GO:0051301,GO:0061640,GO:0061738,GO:0061952,GO:0070062,GO:0072319,GO:0090543,GO:0090611,GO:1902188,GO:1903076,GO:1903543,GO:1903774,GO:1903902,GO:1904896,GO:1904903" actomyosin contractile ring contraction|spindle pole|protein binding|ATP binding|nucleus|cytoplasm|lysosome|endosome|early endosome|late endosome|vacuolar membrane|centrosome|cytosol|plasma membrane|protein targeting to lysosome|vesicle budding from membrane|nucleus organization|nuclear envelope organization|vacuole organization|mitotic metaphase plate congression|protein C-terminus binding|abscission|endosome membrane|vesicle-mediated transport|endosomal transport|macroautophagy|ATPase activity|viral life cycle|viral release from host cell|protein domain specific binding|midbody|nuclear envelope reassembly|late endosome membrane|intracellular cholesterol transport|negative regulation of cytokinesis|regulation of protein localization|endosomal vesicle fusion|multivesicular body assembly|viral budding via host ESCRT complex|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein-containing complex binding|mitotic cytokinesis checkpoint|perinuclear region of cytoplasm|cell division|cytoskeleton-dependent cytokinesis|late endosomal microautophagy|midbody abscission|extracellular exosome|vesicle uncoating|Flemming body|ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway|positive regulation of viral release from host cell|regulation of protein localization to plasma membrane|positive regulation of exosomal secretion|positive regulation of viral budding via host ESCRT complex|positive regulation of viral life cycle|ESCRT complex disassembly|ESCRT III complex disassembly "hsa04144,hsa04217" Endocytosis|Necroptosis VPS4B 2111.151678 2055.857832 2166.445525 1.053791508 0.075589459 0.750691698 1 32.3554568 33.5253568 9525 vacuolar protein sorting 4 homolog B "GO:0000922,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005768,GO:0005813,GO:0005829,GO:0006813,GO:0006997,GO:0007080,GO:0008022,GO:0008568,GO:0010008,GO:0010824,GO:0010971,GO:0015031,GO:0016197,GO:0016236,GO:0016887,GO:0019058,GO:0019076,GO:0030301,GO:0031122,GO:0031902,GO:0032510,GO:0033993,GO:0036258,GO:0039702,GO:0042802,GO:0042803,GO:0043162,GO:0044877,GO:0048524,GO:0050792,GO:0051013,GO:0051261,GO:0060548,GO:0061738,GO:0061952,GO:0070062,GO:0090543,GO:0090611,GO:1901673,GO:1902188,GO:1903542,GO:1903543,GO:1903724,GO:1903902,GO:1904903" spindle pole|protein binding|ATP binding|nucleus|cytoplasm|endosome|centrosome|cytosol|potassium ion transport|nucleus organization|mitotic metaphase plate congression|protein C-terminus binding|microtubule-severing ATPase activity|endosome membrane|regulation of centrosome duplication|positive regulation of G2/M transition of mitotic cell cycle|protein transport|endosomal transport|macroautophagy|ATPase activity|viral life cycle|viral release from host cell|cholesterol transport|cytoplasmic microtubule organization|late endosome membrane|endosome to lysosome transport via multivesicular body sorting pathway|response to lipid|multivesicular body assembly|viral budding via host ESCRT complex|identical protein binding|protein homodimerization activity|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein-containing complex binding|positive regulation of viral process|regulation of viral process|microtubule severing|protein depolymerization|negative regulation of cell death|late endosomal microautophagy|midbody abscission|extracellular exosome|Flemming body|ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway|regulation of mitotic spindle assembly|positive regulation of viral release from host cell|negative regulation of exosomal secretion|positive regulation of exosomal secretion|positive regulation of centriole elongation|positive regulation of viral life cycle|ESCRT III complex disassembly "hsa04144,hsa04217" Endocytosis|Necroptosis VPS50 641.9296054 602.399638 681.4595728 1.13124167 0.177907169 0.495782928 1 4.445991083 4.945328669 55610 VPS50 subunit of EARP/GARPII complex "GO:0000149,GO:0005515,GO:0005829,GO:0015031,GO:0016020,GO:0032456,GO:0042147,GO:0055037,GO:0070062,GO:1990745" "SNARE binding|protein binding|cytosol|protein transport|membrane|endocytic recycling|retrograde transport, endosome to Golgi|recycling endosome|extracellular exosome|EARP complex" VPS51 1548.452044 1615.76276 1481.141328 0.916682427 -0.125506078 0.599708779 1 32.40521941 29.20821729 738 VPS51 subunit of GARP complex "GO:0000938,GO:0003674,GO:0005515,GO:0005730,GO:0005794,GO:0005829,GO:0006869,GO:0006914,GO:0007030,GO:0007041,GO:0015031,GO:0016020,GO:0016021,GO:0032456,GO:0032588,GO:0042147,GO:0043231,GO:0048193,GO:0048854,GO:0055037,GO:1990745" "GARP complex|molecular_function|protein binding|nucleolus|Golgi apparatus|cytosol|lipid transport|autophagy|Golgi organization|lysosomal transport|protein transport|membrane|integral component of membrane|endocytic recycling|trans-Golgi network membrane|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|Golgi vesicle transport|brain morphogenesis|recycling endosome|EARP complex" VPS52 712.484635 726.2088901 698.76038 0.96220301 -0.055586782 0.83277378 1 10.16428895 9.616452533 6293 VPS52 subunit of GARP complex "GO:0000938,GO:0005515,GO:0005794,GO:0005829,GO:0006896,GO:0007041,GO:0010008,GO:0010668,GO:0015031,GO:0016020,GO:0019905,GO:0032456,GO:0032588,GO:0042147,GO:0048471,GO:0048611,GO:0055037,GO:1990745" "GARP complex|protein binding|Golgi apparatus|cytosol|Golgi to vacuole transport|lysosomal transport|endosome membrane|ectodermal cell differentiation|protein transport|membrane|syntaxin binding|endocytic recycling|trans-Golgi network membrane|retrograde transport, endosome to Golgi|perinuclear region of cytoplasm|embryonic ectodermal digestive tract development|recycling endosome|EARP complex" VPS53 903.4710084 933.2512527 873.690764 0.936179578 -0.095142801 0.704583416 1 3.250825933 2.992430395 55275 VPS53 subunit of GARP complex "GO:0000938,GO:0005515,GO:0005794,GO:0005829,GO:0007041,GO:0010008,GO:0015031,GO:0016020,GO:0032456,GO:0032588,GO:0042147,GO:0043231,GO:0048471,GO:0055037,GO:1990745" "GARP complex|protein binding|Golgi apparatus|cytosol|lysosomal transport|endosome membrane|protein transport|membrane|endocytic recycling|trans-Golgi network membrane|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|recycling endosome|EARP complex" VPS54 853.8827722 855.2202115 852.545333 0.996872293 -0.004519399 0.990902291 1 10.61677852 10.40647059 51542 VPS54 subunit of GARP complex "GO:0000938,GO:0005515,GO:0005654,GO:0005794,GO:0005802,GO:0005829,GO:0006896,GO:0007041,GO:0015031,GO:0016020,GO:0019905,GO:0032588,GO:0040008,GO:0042147,GO:0048471,GO:0048873,GO:0050881,GO:0060052" "GARP complex|protein binding|nucleoplasm|Golgi apparatus|trans-Golgi network|cytosol|Golgi to vacuole transport|lysosomal transport|protein transport|membrane|syntaxin binding|trans-Golgi network membrane|regulation of growth|retrograde transport, endosome to Golgi|perinuclear region of cytoplasm|homeostasis of number of cells within a tissue|musculoskeletal movement|neurofilament cytoskeleton organization" VPS72 1001.434074 1019.605605 983.262543 0.964355765 -0.052362619 0.834955363 1 34.94828335 33.13861151 6944 vacuolar protein sorting 72 homolog "GO:0000122,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0016607,GO:0032991,GO:0035019,GO:0042393,GO:0043486" negative regulation of transcription by RNA polymerase II|DNA binding|protein binding|nucleus|nucleoplasm|nuclear speck|protein-containing complex|somatic stem cell population maintenance|histone binding|histone exchange VPS8 989.9794604 1021.686433 958.2724881 0.937932087 -0.09244463 0.709974328 1 7.538438703 6.952227574 23355 VPS8 subunit of CORVET complex "GO:0005515,GO:0005769,GO:0015031,GO:0033263,GO:0034058,GO:0046872" protein binding|early endosome|protein transport|CORVET complex|endosomal vesicle fusion|metal ion binding VPS9D1 265.505528 233.0527097 297.9583464 1.278501961 0.354454373 0.28173112 1 3.478074604 4.372315277 9605 VPS9 domain containing 1 "GO:0005096,GO:0005215,GO:0005515,GO:0015986,GO:0042802,GO:0043547" GTPase activator activity|transporter activity|protein binding|ATP synthesis coupled proton transport|identical protein binding|positive regulation of GTPase activity VRK1 814.510591 767.8254454 861.1957366 1.121603539 0.165562806 0.511608452 1 21.34241293 23.53716044 7443 VRK serine/threonine kinase 1 "GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005795,GO:0005819,GO:0005829,GO:0006468,GO:0007077,GO:0007084,GO:0018105,GO:0019901,GO:0031493,GO:0035175,GO:0043987,GO:0046777,GO:0051301,GO:0072354,GO:0072355,GO:0090166,GO:0106310,GO:0106311" protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|Golgi stack|spindle|cytosol|protein phosphorylation|mitotic nuclear envelope disassembly|mitotic nuclear envelope reassembly|peptidyl-serine phosphorylation|protein kinase binding|nucleosomal histone binding|histone kinase activity (H3-S10 specific)|histone H3-S10 phosphorylation|protein autophosphorylation|cell division|histone kinase activity (H3-T3 specific)|histone H3-T3 phosphorylation|Golgi disassembly|protein serine kinase activity|protein threonine kinase activity VRK2 646.7448317 678.3498515 615.1398118 0.906817935 -0.141115169 0.589576608 1 6.54061153 5.831894185 7444 VRK serine/threonine kinase 2 "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005635,GO:0005737,GO:0005783,GO:0005789,GO:0006468,GO:0016021,GO:0016032,GO:0018105,GO:0019901,GO:0019904,GO:0031966,GO:0032991,GO:0034599,GO:0043408,GO:0046777,GO:0106310,GO:0106311,GO:2000659" protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nuclear envelope|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|protein phosphorylation|integral component of membrane|viral process|peptidyl-serine phosphorylation|protein kinase binding|protein domain specific binding|mitochondrial membrane|protein-containing complex|cellular response to oxidative stress|regulation of MAPK cascade|protein autophosphorylation|protein serine kinase activity|protein threonine kinase activity|regulation of interleukin-1-mediated signaling pathway VRK3 465.9053161 434.8930029 496.9176292 1.142620428 0.192346228 0.491966124 1 8.818176394 9.907223142 51231 VRK serine/threonine kinase 3 "GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0018105,GO:0019903,GO:0032516,GO:0043231,GO:0070373" protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|peptidyl-serine phosphorylation|protein phosphatase binding|positive regulation of phosphoprotein phosphatase activity|intracellular membrane-bounded organelle|negative regulation of ERK1 and ERK2 cascade VSIG1 85.46300778 98.83931885 72.0866967 0.729332188 -0.455352028 0.36146582 1 1.537415561 1.102523441 340547 V-set and immunoglobulin domain containing 1 "GO:0003382,GO:0005515,GO:0016021,GO:0016323,GO:0030277" epithelial cell morphogenesis|protein binding|integral component of membrane|basolateral plasma membrane|maintenance of gastrointestinal epithelium VSIG10 626.8429897 673.1477821 580.5381974 0.862423101 -0.213532273 0.414534915 1 6.482255492 5.496898323 54621 V-set and immunoglobulin domain containing 10 "GO:0005887,GO:0005911,GO:0050839,GO:0098609" integral component of plasma membrane|cell-cell junction|cell adhesion molecule binding|cell-cell adhesion VSIG10L 65.17493706 58.26317743 72.0866967 1.237259962 0.307148659 0.587723117 1 0.842883897 1.02541554 147645 V-set and immunoglobulin domain containing 10 like "GO:0005654,GO:0016021" nucleoplasm|integral component of membrane VSIG8 5.524131538 6.242483296 4.80577978 0.769850643 -0.377349516 0.927604977 1 0.183250748 0.138714995 391123 V-set and immunoglobulin domain containing 8 "GO:0003723,GO:0005622,GO:0016021" RNA binding|intracellular anatomical structure|integral component of membrane VSIR 646.8492417 618.0058463 675.6926371 1.093343439 0.128746648 0.623213743 1 6.996571101 7.521648487 64115 V-set immunoregulatory receptor "GO:0005515,GO:0005886,GO:0010628,GO:0010950,GO:0016021,GO:0019899,GO:0030335,GO:0031638,GO:0032689,GO:0032693,GO:0032700,GO:0032720,GO:0042802,GO:0045591,GO:0050776,GO:0061133,GO:0120158,GO:2000562,GO:2000565" "protein binding|plasma membrane|positive regulation of gene expression|positive regulation of endopeptidase activity|integral component of membrane|enzyme binding|positive regulation of cell migration|zymogen activation|negative regulation of interferon-gamma production|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of tumor necrosis factor production|identical protein binding|positive regulation of regulatory T cell differentiation|regulation of immune response|endopeptidase activator activity|positive regulation of collagen catabolic process|negative regulation of CD4-positive, alpha-beta T cell proliferation|negative regulation of CD8-positive, alpha-beta T cell proliferation" hsa04514 Cell adhesion molecules VSTM1 187.0379539 166.4662212 207.6096865 1.247158042 0.318644297 0.396619271 1 5.829393881 7.148518917 284415 V-set and transmembrane domain containing 1 "GO:0002376,GO:0005125,GO:0005615,GO:0007165,GO:0016021" immune system process|cytokine activity|extracellular space|signal transduction|integral component of membrane VSTM2L 2.883467868 0 5.766935736 Inf Inf 0.126446699 1 0 0.154477098 128434 V-set and transmembrane domain containing 2 like "GO:0005515,GO:0005576,GO:0005737,GO:0005886,GO:0007156,GO:0007411,GO:0030424,GO:0043524,GO:0070593,GO:0098632" protein binding|extracellular region|cytoplasm|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|axon guidance|axon|negative regulation of neuron apoptotic process|dendrite self-avoidance|cell-cell adhesion mediator activity VTA1 993.5762496 1040.413883 946.7386167 0.90996346 -0.13611948 0.581949664 1 7.942351125 7.106311082 51534 vesicle trafficking 1 "GO:0005515,GO:0005654,GO:0005771,GO:0005829,GO:0008022,GO:0010008,GO:0015031,GO:0016197,GO:0016236,GO:0019058,GO:0032511,GO:0036258,GO:0043231,GO:0046755,GO:0070062,GO:0071985,GO:1904903" protein binding|nucleoplasm|multivesicular body|cytosol|protein C-terminus binding|endosome membrane|protein transport|endosomal transport|macroautophagy|viral life cycle|late endosome to vacuole transport via multivesicular body sorting pathway|multivesicular body assembly|intracellular membrane-bounded organelle|viral budding|extracellular exosome|multivesicular body sorting pathway|ESCRT III complex disassembly hsa04144 Endocytosis VTI1A 337.6708683 336.0536841 339.2880525 1.009624559 0.013818909 0.974642941 1 2.450077525 2.432265115 143187 vesicle transport through interaction with t-SNAREs 1A "GO:0000139,GO:0000149,GO:0005484,GO:0005515,GO:0005768,GO:0005776,GO:0005789,GO:0005794,GO:0005829,GO:0006623,GO:0006888,GO:0006891,GO:0006896,GO:0006914,GO:0008021,GO:0012507,GO:0016021,GO:0030136,GO:0031201,GO:0031902,GO:0032588,GO:0042147,GO:0043025,GO:0043231,GO:0044306,GO:0048280,GO:0048471,GO:0050882,GO:0090161" "Golgi membrane|SNARE binding|SNAP receptor activity|protein binding|endosome|autophagosome|endoplasmic reticulum membrane|Golgi apparatus|cytosol|protein targeting to vacuole|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|Golgi to vacuole transport|autophagy|synaptic vesicle|ER to Golgi transport vesicle membrane|integral component of membrane|clathrin-coated vesicle|SNARE complex|late endosome membrane|trans-Golgi network membrane|retrograde transport, endosome to Golgi|neuronal cell body|intracellular membrane-bounded organelle|neuron projection terminus|vesicle fusion with Golgi apparatus|perinuclear region of cytoplasm|voluntary musculoskeletal movement|Golgi ribbon formation" hsa04130 SNARE interactions in vesicular transport VTI1B 2289.187598 2200.475362 2377.899835 1.080630066 0.111872727 0.636968365 1 22.83845308 24.26693404 10490 vesicle transport through interaction with t-SNAREs 1B "GO:0000149,GO:0002576,GO:0005484,GO:0005515,GO:0005576,GO:0005765,GO:0005789,GO:0005794,GO:0005829,GO:0006623,GO:0006888,GO:0006891,GO:0006896,GO:0006904,GO:0008021,GO:0012507,GO:0016021,GO:0016192,GO:0019869,GO:0031093,GO:0031201,GO:0031901,GO:0031902,GO:0031982,GO:0042147,GO:0043025,GO:0043231,GO:0048280,GO:0048471,GO:0055037,GO:0055038,GO:0061025,GO:0097352,GO:1903076" "SNARE binding|platelet degranulation|SNAP receptor activity|protein binding|extracellular region|lysosomal membrane|endoplasmic reticulum membrane|Golgi apparatus|cytosol|protein targeting to vacuole|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|Golgi to vacuole transport|vesicle docking involved in exocytosis|synaptic vesicle|ER to Golgi transport vesicle membrane|integral component of membrane|vesicle-mediated transport|chloride channel inhibitor activity|platelet alpha granule lumen|SNARE complex|early endosome membrane|late endosome membrane|vesicle|retrograde transport, endosome to Golgi|neuronal cell body|intracellular membrane-bounded organelle|vesicle fusion with Golgi apparatus|perinuclear region of cytoplasm|recycling endosome|recycling endosome membrane|membrane fusion|autophagosome maturation|regulation of protein localization to plasma membrane" hsa04130 SNARE interactions in vesicular transport VTN 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.102444606 0.093056776 7448 vitronectin "GO:0005044,GO:0005178,GO:0005201,GO:0005515,GO:0005576,GO:0005615,GO:0005783,GO:0006897,GO:0006955,GO:0007155,GO:0007160,GO:0008201,GO:0010951,GO:0014911,GO:0016477,GO:0030195,GO:0030198,GO:0030247,GO:0030449,GO:0030949,GO:0032092,GO:0033627,GO:0035987,GO:0043231,GO:0048260,GO:0050731,GO:0061302,GO:0062023,GO:0070062,GO:0071062,GO:0072562,GO:0090303" scavenger receptor activity|integrin binding|extracellular matrix structural constituent|protein binding|extracellular region|extracellular space|endoplasmic reticulum|endocytosis|immune response|cell adhesion|cell-matrix adhesion|heparin binding|negative regulation of endopeptidase activity|positive regulation of smooth muscle cell migration|cell migration|negative regulation of blood coagulation|extracellular matrix organization|polysaccharide binding|regulation of complement activation|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of protein binding|cell adhesion mediated by integrin|endodermal cell differentiation|intracellular membrane-bounded organelle|positive regulation of receptor-mediated endocytosis|positive regulation of peptidyl-tyrosine phosphorylation|smooth muscle cell-matrix adhesion|collagen-containing extracellular matrix|extracellular exosome|alphav-beta3 integrin-vitronectin complex|blood microparticle|positive regulation of wound healing "hsa04151,hsa04510,hsa04512,hsa04610,hsa05165,hsa05205" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Complement and coagulation cascades|Human papillomavirus infection|Proteoglycans in cancer VWA1 16.53276565 17.687036 15.3784953 0.869478373 -0.201777951 0.890777234 1 0.210134596 0.179650124 64856 von Willebrand factor A domain containing 1 "GO:0005201,GO:0005604,GO:0005614,GO:0005615,GO:0005788,GO:0030198,GO:0042802,GO:0043687,GO:0044267,GO:0048266,GO:0062023,GO:0070062" extracellular matrix structural constituent|basement membrane|interstitial matrix|extracellular space|endoplasmic reticulum lumen|extracellular matrix organization|identical protein binding|post-translational protein modification|cellular protein metabolic process|behavioral response to pain|collagen-containing extracellular matrix|extracellular exosome VWA5A 2.080827765 4.161655531 0 0 #NAME? 0.234194363 1 0.044625258 0 4013 von Willebrand factor A domain containing 5A "GO:0005515,GO:0005654" protein binding|nucleoplasm VWA5B2 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.035031531 0.04242841 90113 von Willebrand factor A domain containing 5B2 VWA7 22.05689719 23.9295193 20.18427508 0.843488531 -0.245559643 0.811591529 1 0.29223672 0.242373506 80737 von Willebrand factor A domain containing 7 "GO:0003674,GO:0005575,GO:0005576,GO:0008150" molecular_function|cellular_component|extracellular region|biological_process VWA8 803.5309106 883.3113864 723.7504349 0.819360472 -0.287429799 0.253301781 1 6.346352347 5.112936132 23078 von Willebrand factor A domain containing 8 "GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005777,GO:0016887" protein binding|ATP binding|cytoplasm|mitochondrion|peroxisome|ATPase activity VWCE 2.962725795 2.080827765 3.844623824 1.847641543 0.88568489 0.829811711 1 0.030890112 0.056118801 220001 von Willebrand factor C and EGF domains "GO:0003674,GO:0005509,GO:0005515,GO:0005576,GO:0005737,GO:0098586" molecular_function|calcium ion binding|protein binding|extracellular region|cytoplasm|cellular response to virus VWDE 234.6642491 243.4568485 225.8716497 0.927768724 -0.108162883 0.76214966 1 1.594214055 1.454311841 221806 von Willebrand factor D and EGF domains "GO:0005102,GO:0005576,GO:0009986,GO:0048856" signaling receptor binding|extracellular region|cell surface|anatomical structure development VWF 10.00784919 10.40413883 9.61155956 0.923820772 -0.11431511 1 1 0.062882193 0.057119787 7450 von Willebrand factor "GO:0002020,GO:0002576,GO:0005178,GO:0005201,GO:0005515,GO:0005518,GO:0005576,GO:0005615,GO:0005783,GO:0007155,GO:0007596,GO:0007597,GO:0007599,GO:0009611,GO:0019865,GO:0030168,GO:0030198,GO:0031012,GO:0031091,GO:0031093,GO:0031589,GO:0033093,GO:0042802,GO:0047485,GO:0051087,GO:0062023,GO:0070062" "protease binding|platelet degranulation|integrin binding|extracellular matrix structural constituent|protein binding|collagen binding|extracellular region|extracellular space|endoplasmic reticulum|cell adhesion|blood coagulation|blood coagulation, intrinsic pathway|hemostasis|response to wounding|immunoglobulin binding|platelet activation|extracellular matrix organization|extracellular matrix|platelet alpha granule|platelet alpha granule lumen|cell-substrate adhesion|Weibel-Palade body|identical protein binding|protein N-terminus binding|chaperone binding|collagen-containing extracellular matrix|extracellular exosome" "hsa04151,hsa04510,hsa04512,hsa04610,hsa04611,hsa05165,hsa05171" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Complement and coagulation cascades|Platelet activation|Human papillomavirus infection|Coronavirus disease - COVID-19 VXN 13.411524 11.44455271 15.3784953 1.343739304 0.426253271 0.726340813 1 0.193589459 0.255780779 254778 vexin "GO:0005515,GO:0005634,GO:0005886,GO:0022008,GO:0030182" protein binding|nucleus|plasma membrane|neurogenesis|neuron differentiation WAC 2558.803863 2667.621195 2449.986532 0.918416204 -0.122779999 0.604226394 1 35.2827857 31.86204033 51322 WW domain containing adaptor with coiled-coil "GO:0000993,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0006974,GO:0010390,GO:0016239,GO:0016567,GO:0016607,GO:0032435,GO:0044783,GO:0045893,GO:0071894" "RNA polymerase II complex binding|chromatin binding|protein binding|nucleus|nucleoplasm|cellular response to DNA damage stimulus|histone monoubiquitination|positive regulation of macroautophagy|protein ubiquitination|nuclear speck|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|G1 DNA damage checkpoint|positive regulation of transcription, DNA-templated|histone H2B conserved C-terminal lysine ubiquitination" WAPL 3232.878088 3205.515172 3260.241003 1.017072398 0.024422378 0.919241177 1 21.4699364 21.47107578 23063 WAPL cohesin release factor "GO:0000278,GO:0000775,GO:0000785,GO:0000795,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0008156,GO:0009636,GO:0016032,GO:0035562,GO:0045132,GO:0045171,GO:0045875,GO:0048146,GO:0051301,GO:0051983,GO:0060623,GO:0071168,GO:0071922,GO:0072686" "mitotic cell cycle|chromosome, centromeric region|chromatin|synaptonemal complex|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|Golgi apparatus|centrosome|cytosol|negative regulation of DNA replication|response to toxic substance|viral process|negative regulation of chromatin binding|meiotic chromosome segregation|intercellular bridge|negative regulation of sister chromatid cohesion|positive regulation of fibroblast proliferation|cell division|regulation of chromosome segregation|regulation of chromosome condensation|protein localization to chromatin|regulation of cohesin loading|mitotic spindle" WARS1 2794.536251 3241.929658 2347.142845 0.723995611 -0.465947143 0.049041631 1 58.98937179 41.99338497 7453 tryptophanyl-tRNA synthetase 1 "GO:0001525,GO:0001933,GO:0004830,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006412,GO:0006418,GO:0006436,GO:0006469,GO:0008285,GO:0010628,GO:0010835,GO:0019210,GO:0019901,GO:0019904,GO:0031334,GO:0032991,GO:0042803,GO:0045765,GO:0070062" angiogenesis|negative regulation of protein phosphorylation|tryptophan-tRNA ligase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|translation|tRNA aminoacylation for protein translation|tryptophanyl-tRNA aminoacylation|negative regulation of protein kinase activity|negative regulation of cell population proliferation|positive regulation of gene expression|regulation of protein ADP-ribosylation|kinase inhibitor activity|protein kinase binding|protein domain specific binding|positive regulation of protein-containing complex assembly|protein-containing complex|protein homodimerization activity|regulation of angiogenesis|extracellular exosome hsa00970 Aminoacyl-tRNA biosynthesis WARS2 251.2963943 213.2848459 289.3079428 1.356439279 0.439824467 0.188986351 1 3.484120057 4.646914136 10352 "tryptophanyl tRNA synthetase 2, mitochondrial" "GO:0001570,GO:0004830,GO:0005524,GO:0005654,GO:0005739,GO:0005759,GO:0005886,GO:0006418,GO:0006436,GO:0070183" vasculogenesis|tryptophan-tRNA ligase activity|ATP binding|nucleoplasm|mitochondrion|mitochondrial matrix|plasma membrane|tRNA aminoacylation for protein translation|tryptophanyl-tRNA aminoacylation|mitochondrial tryptophanyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis WAS 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.02342826 0.063844016 7454 WASP actin nucleation promoting factor "GO:0002625,GO:0003779,GO:0005515,GO:0005634,GO:0005829,GO:0005884,GO:0005886,GO:0005911,GO:0006952,GO:0006955,GO:0007266,GO:0007596,GO:0008064,GO:0008154,GO:0008544,GO:0010591,GO:0012506,GO:0015629,GO:0016197,GO:0017124,GO:0019901,GO:0030041,GO:0030048,GO:0030695,GO:0031267,GO:0032488,GO:0035861,GO:0038096,GO:0042110,GO:0042802,GO:0043274,GO:0045335,GO:0045944,GO:0050790,GO:0050852,GO:0051492,GO:0051497,GO:0065003,GO:0070062,GO:0071346,GO:1905168,GO:2000146,GO:2000601,GO:2001032" regulation of T cell antigen processing and presentation|actin binding|protein binding|nucleus|cytosol|actin filament|plasma membrane|cell-cell junction|defense response|immune response|Rho protein signal transduction|blood coagulation|regulation of actin polymerization or depolymerization|actin polymerization or depolymerization|epidermis development|regulation of lamellipodium assembly|vesicle membrane|actin cytoskeleton|endosomal transport|SH3 domain binding|protein kinase binding|actin filament polymerization|actin filament-based movement|GTPase regulator activity|small GTPase binding|Cdc42 protein signal transduction|site of double-strand break|Fc-gamma receptor signaling pathway involved in phagocytosis|T cell activation|identical protein binding|phospholipase binding|phagocytic vesicle|positive regulation of transcription by RNA polymerase II|regulation of catalytic activity|T cell receptor signaling pathway|regulation of stress fiber assembly|negative regulation of stress fiber assembly|protein-containing complex assembly|extracellular exosome|cellular response to interferon-gamma|positive regulation of double-strand break repair via homologous recombination|negative regulation of cell motility|positive regulation of Arp2/3 complex-mediated actin nucleation|regulation of double-strand break repair via nonhomologous end joining "hsa04062,hsa04520,hsa04530,hsa04666,hsa05135,hsa05231" Chemokine signaling pathway|Adherens junction|Tight junction|Fc gamma R-mediated phagocytosis|Yersinia infection|Choline metabolism in cancer WASF1 415.9994339 449.4587973 382.5400705 0.851112655 -0.232577992 0.418543369 1 8.311431026 6.955590922 8936 WASP family member 1 "GO:0003779,GO:0005515,GO:0005741,GO:0005856,GO:0005925,GO:0006898,GO:0015629,GO:0016601,GO:0030027,GO:0030036,GO:0030041,GO:0031209,GO:0031267,GO:0032839,GO:0032991,GO:0034237,GO:0051018,GO:0051388,GO:0065003,GO:0070584,GO:0071933,GO:0072673,GO:0097484,GO:0098794,GO:0098885,GO:0098939,GO:1990416,GO:2000601" actin binding|protein binding|mitochondrial outer membrane|cytoskeleton|focal adhesion|receptor-mediated endocytosis|actin cytoskeleton|Rac protein signal transduction|lamellipodium|actin cytoskeleton organization|actin filament polymerization|SCAR complex|small GTPase binding|dendrite cytoplasm|protein-containing complex|protein kinase A regulatory subunit binding|protein kinase A binding|positive regulation of neurotrophin TRK receptor signaling pathway|protein-containing complex assembly|mitochondrion morphogenesis|Arp2/3 complex binding|lamellipodium morphogenesis|dendrite extension|postsynapse|modification of postsynaptic actin cytoskeleton|dendritic transport of mitochondrion|cellular response to brain-derived neurotrophic factor stimulus|positive regulation of Arp2/3 complex-mediated actin nucleation "hsa04520,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05231" Adherens junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Choline metabolism in cancer WASF2 3556.409019 3548.851754 3563.966285 1.004258992 0.006131379 0.980727992 1 33.33844316 32.92018164 10163 WASP family member 2 "GO:0001525,GO:0001667,GO:0001726,GO:0003779,GO:0005515,GO:0005769,GO:0005829,GO:0005911,GO:0006897,GO:0007188,GO:0010592,GO:0015629,GO:0016032,GO:0016323,GO:0016601,GO:0017124,GO:0030027,GO:0030032,GO:0030036,GO:0030048,GO:0031209,GO:0032991,GO:0034237,GO:0035855,GO:0038096,GO:0045202,GO:0045296,GO:0048010,GO:0051018,GO:0051497,GO:0070062,GO:0071933,GO:0072673,GO:0098974,GO:2000601" angiogenesis|ameboidal-type cell migration|ruffle|actin binding|protein binding|early endosome|cytosol|cell-cell junction|endocytosis|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|positive regulation of lamellipodium assembly|actin cytoskeleton|viral process|basolateral plasma membrane|Rac protein signal transduction|SH3 domain binding|lamellipodium|lamellipodium assembly|actin cytoskeleton organization|actin filament-based movement|SCAR complex|protein-containing complex|protein kinase A regulatory subunit binding|megakaryocyte development|Fc-gamma receptor signaling pathway involved in phagocytosis|synapse|cadherin binding|vascular endothelial growth factor receptor signaling pathway|protein kinase A binding|negative regulation of stress fiber assembly|extracellular exosome|Arp2/3 complex binding|lamellipodium morphogenesis|postsynaptic actin cytoskeleton organization|positive regulation of Arp2/3 complex-mediated actin nucleation "hsa04520,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05135,hsa05231" Adherens junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Yersinia infection|Choline metabolism in cancer WASF3 332.6122235 367.2661006 297.9583464 0.811287363 -0.301715078 0.323740195 1 3.618297357 2.886357658 10810 WASP family member 3 "GO:0003779,GO:0005856,GO:0007010,GO:0008360,GO:0014003,GO:0030027,GO:0030032,GO:0030036,GO:0030041,GO:0031209,GO:0031643,GO:0034237,GO:0065003,GO:0070062,GO:0071933,GO:0098794,GO:0098885,GO:0098978,GO:2000601" actin binding|cytoskeleton|cytoskeleton organization|regulation of cell shape|oligodendrocyte development|lamellipodium|lamellipodium assembly|actin cytoskeleton organization|actin filament polymerization|SCAR complex|positive regulation of myelination|protein kinase A regulatory subunit binding|protein-containing complex assembly|extracellular exosome|Arp2/3 complex binding|postsynapse|modification of postsynaptic actin cytoskeleton|glutamatergic synapse|positive regulation of Arp2/3 complex-mediated actin nucleation "hsa04520,hsa04666,hsa05130,hsa05132,hsa05231" Adherens junction|Fc gamma R-mediated phagocytosis|Pathogenic Escherichia coli infection|Salmonella infection|Choline metabolism in cancer WASHC1 145.9957113 148.7791852 143.2122374 0.962582482 -0.055017926 0.910311598 1 1.438418781 1.36142737 100287171 WASH complex subunit 1 "GO:0000145,GO:0003779,GO:0005515,GO:0005769,GO:0005770,GO:0005776,GO:0005814,GO:0005829,GO:0006887,GO:0010507,GO:0015031,GO:0016197,GO:0022617,GO:0030335,GO:0031274,GO:0031396,GO:0031625,GO:0031901,GO:0034314,GO:0042147,GO:0043014,GO:0043231,GO:0043553,GO:0055037,GO:0055038,GO:0071203,GO:1990126" "exocyst|actin binding|protein binding|early endosome|late endosome|autophagosome|centriole|cytosol|exocytosis|negative regulation of autophagy|protein transport|endosomal transport|extracellular matrix disassembly|positive regulation of cell migration|positive regulation of pseudopodium assembly|regulation of protein ubiquitination|ubiquitin protein ligase binding|early endosome membrane|Arp2/3 complex-mediated actin nucleation|retrograde transport, endosome to Golgi|alpha-tubulin binding|intracellular membrane-bounded organelle|negative regulation of phosphatidylinositol 3-kinase activity|recycling endosome|recycling endosome membrane|WASH complex|retrograde transport, endosome to plasma membrane" hsa04144 Endocytosis WASHC2A 1363.31125 1511.721371 1214.901128 0.803654133 -0.315353349 0.188652763 1 16.45813773 13.00532033 387680 WASH complex subunit 2A "GO:0005515,GO:0005730,GO:0005769,GO:0005829,GO:0005886,GO:0008289,GO:0015031,GO:0031901,GO:0036010,GO:0042147,GO:0043231,GO:0071203" "protein binding|nucleolus|early endosome|cytosol|plasma membrane|lipid binding|protein transport|early endosome membrane|protein localization to endosome|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|WASH complex" hsa04144 Endocytosis WASHC2C 1358.743244 1517.963855 1199.522633 0.790218179 -0.339677059 0.156844682 1 15.55211001 12.08391091 253725 WASH complex subunit 2C "GO:0005515,GO:0005546,GO:0005547,GO:0005730,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0010314,GO:0015031,GO:0031901,GO:0032266,GO:0036010,GO:0042147,GO:0043231,GO:0043325,GO:0070273,GO:0071203,GO:0080025,GO:1900024,GO:1905394,GO:1990126,GO:2000813" "protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleolus|endosome|early endosome|cytosol|plasma membrane|phosphatidylinositol-5-phosphate binding|protein transport|early endosome membrane|phosphatidylinositol-3-phosphate binding|protein localization to endosome|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4-phosphate binding|WASH complex|phosphatidylinositol-3,5-bisphosphate binding|regulation of substrate adhesion-dependent cell spreading|retromer complex binding|retrograde transport, endosome to plasma membrane|negative regulation of barbed-end actin filament capping" hsa04144 Endocytosis WASHC3 577.215739 493.1561804 661.2752977 1.340904411 0.423206396 0.11022891 1 25.60198343 33.7553496 51019 WASH complex subunit 3 "GO:0005515,GO:0005769,GO:0006887,GO:0008150,GO:0015031,GO:0030041,GO:0071203" protein binding|early endosome|exocytosis|biological_process|protein transport|actin filament polymerization|WASH complex hsa04144 Endocytosis WASHC4 2851.485299 2743.571409 2959.399189 1.078666726 0.109249186 0.645010557 1 23.36354932 24.77977056 23325 WASH complex subunit 4 "GO:0005654,GO:0005768,GO:0005769,GO:0007032,GO:0015031,GO:0016197,GO:0031083,GO:0071203" nucleoplasm|endosome|early endosome|endosome organization|protein transport|endosomal transport|BLOC-1 complex|WASH complex hsa04144 Endocytosis WASHC5 2538.673694 2732.126856 2345.220533 0.858386399 -0.220300878 0.351526853 1 26.90195366 22.70585324 9897 WASH complex subunit 5 "GO:0001556,GO:0005515,GO:0005654,GO:0005768,GO:0005769,GO:0005783,GO:0005829,GO:0007032,GO:0007040,GO:0010976,GO:0015031,GO:0016197,GO:0030041,GO:0034629,GO:0040038,GO:0043005,GO:0043025,GO:0051125,GO:0071203,GO:0090306,GO:0097494,GO:0140285" oocyte maturation|protein binding|nucleoplasm|endosome|early endosome|endoplasmic reticulum|cytosol|endosome organization|lysosome organization|positive regulation of neuron projection development|protein transport|endosomal transport|actin filament polymerization|cellular protein-containing complex localization|polar body extrusion after meiotic divisions|neuron projection|neuronal cell body|regulation of actin nucleation|WASH complex|spindle assembly involved in meiosis|regulation of vesicle size|endosome fission hsa04144 Endocytosis WASL 1594.423984 1624.086071 1564.761896 0.963472272 -0.053684948 0.823818872 1 19.86580075 18.81986372 8976 WASP like actin nucleation promoting factor "GO:0003779,GO:0005515,GO:0005634,GO:0005829,GO:0005884,GO:0005886,GO:0006900,GO:0008154,GO:0009617,GO:0015629,GO:0016050,GO:0030027,GO:0030041,GO:0030048,GO:0030050,GO:0030478,GO:0030666,GO:0030695,GO:0031410,GO:0032880,GO:0034629,GO:0038096,GO:0045944,GO:0048013,GO:0050999,GO:0051301,GO:0051491,GO:0051653,GO:0060997,GO:0061024,GO:0065003,GO:0070062,GO:1903526,GO:2000370,GO:2000402,GO:2000601" actin binding|protein binding|nucleus|cytosol|actin filament|plasma membrane|vesicle budding from membrane|actin polymerization or depolymerization|response to bacterium|actin cytoskeleton|vesicle organization|lamellipodium|actin filament polymerization|actin filament-based movement|vesicle transport along actin filament|actin cap|endocytic vesicle membrane|GTPase regulator activity|cytoplasmic vesicle|regulation of protein localization|cellular protein-containing complex localization|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of transcription by RNA polymerase II|ephrin receptor signaling pathway|regulation of nitric-oxide synthase activity|cell division|positive regulation of filopodium assembly|spindle localization|dendritic spine morphogenesis|membrane organization|protein-containing complex assembly|extracellular exosome|negative regulation of membrane tubulation|positive regulation of clathrin-dependent endocytosis|negative regulation of lymphocyte migration|positive regulation of Arp2/3 complex-mediated actin nucleation "hsa04144,hsa04520,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05135" Endocytosis|Adherens junction|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Yersinia infection WBP1 555.7281242 547.2577023 564.1985462 1.03095588 0.043982594 0.875781317 1 24.85628745 25.19692372 23559 WW domain binding protein 1 "GO:0005515,GO:0005575,GO:0008150,GO:0050699" protein binding|cellular_component|biological_process|WW domain binding WBP11 2610.488633 2611.438845 2609.538421 0.999272269 -0.001050276 0.998314692 1 30.42298441 29.89212769 51729 WW domain binding protein 11 "GO:0000398,GO:0003697,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005829,GO:0006364,GO:0043231,GO:0045292,GO:0050699" "mRNA splicing, via spliceosome|single-stranded DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|cytosol|rRNA processing|intracellular membrane-bounded organelle|mRNA cis splicing, via spliceosome|WW domain binding" hsa03040 Spliceosome WBP1L 1980.633842 1859.219608 2102.048076 1.130607738 0.177098476 0.454790482 1 16.78902426 18.66416602 54838 WW domain binding protein 1 like "GO:0005515,GO:0016021" protein binding|integral component of membrane WBP2 3692.709497 3607.114931 3778.304063 1.047458741 0.066893417 0.779165483 1 94.64360584 97.47637766 23558 WW domain binding protein 2 "GO:0000785,GO:0000978,GO:0003713,GO:0005515,GO:0005634,GO:0005737,GO:0030331,GO:0031490,GO:0032570,GO:0033148,GO:0043627,GO:0045184,GO:0045815,GO:0045893,GO:0045944,GO:0050847,GO:0071391,GO:0071442" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|transcription coactivator activity|protein binding|nucleus|cytoplasm|estrogen receptor binding|chromatin DNA binding|response to progesterone|positive regulation of intracellular estrogen receptor signaling pathway|response to estrogen|establishment of protein localization|positive regulation of gene expression, epigenetic|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|progesterone receptor signaling pathway|cellular response to estrogen stimulus|positive regulation of histone H3-K14 acetylation" WBP4 402.9200329 408.8826559 396.9574098 0.970834551 -0.042702641 0.890974919 1 8.659252321 8.266026581 11193 WW domain binding protein 4 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0008270,GO:0008380,GO:0016607,GO:0045292,GO:0070064,GO:0071005,GO:0071011" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|zinc ion binding|RNA splicing|nuclear speck|mRNA cis splicing, via spliceosome|proline-rich region binding|U2-type precatalytic spliceosome|precatalytic spliceosome" WDCP 394.3388263 435.9334168 352.7442358 0.809169984 -0.305485291 0.293586094 1 5.96690568 4.747446898 80304 WD repeat and coiled coil containing "GO:0019900,GO:0051259" kinase binding|protein complex oligomerization WDFY1 3512.874568 3554.053823 3471.695313 0.976826882 -0.033825192 0.887807035 1 41.1706795 39.54365569 57590 WD repeat and FYVE domain containing 1 "GO:0005515,GO:0005545,GO:0005634,GO:0005769,GO:0005829,GO:0008270,GO:0034141,GO:0034145" protein binding|1-phosphatidylinositol binding|nucleus|early endosome|cytosol|zinc ion binding|positive regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway WDFY2 1814.830638 1669.864282 1959.796994 1.173626513 0.230973368 0.330136598 1 6.080206566 7.016482148 115825 WD repeat and FYVE domain containing 2 "GO:0001934,GO:0005515,GO:0005769,GO:0031982,GO:0043231,GO:0045600,GO:0046872" positive regulation of protein phosphorylation|protein binding|early endosome|vesicle|intracellular membrane-bounded organelle|positive regulation of fat cell differentiation|metal ion binding WDFY3 1477.722793 1626.166899 1329.278687 0.817430664 -0.290831732 0.223324023 1 5.915448068 4.754553621 23001 WD repeat and FYVE domain containing 3 "GO:0005515,GO:0005545,GO:0005635,GO:0005654,GO:0005730,GO:0005737,GO:0005776,GO:0005829,GO:0005886,GO:0007275,GO:0016234,GO:0016605,GO:0019898,GO:0030424,GO:0031965,GO:0034274,GO:0035973,GO:0043204,GO:0046872,GO:0097635" protein binding|1-phosphatidylinositol binding|nuclear envelope|nucleoplasm|nucleolus|cytoplasm|autophagosome|cytosol|plasma membrane|multicellular organism development|inclusion body|PML body|extrinsic component of membrane|axon|nuclear membrane|Atg12-Atg5-Atg16 complex|aggrephagy|perikaryon|metal ion binding|extrinsic component of autophagosome membrane WDHD1 1562.220229 1636.571037 1487.86942 0.909138306 -0.137428309 0.565112407 1 14.51084705 12.9716105 11169 WD repeat and HMG-box DNA binding protein 1 "GO:0000278,GO:0003677,GO:0003682,GO:0005515,GO:0005654,GO:0005737,GO:0006261,GO:0006281,GO:0043596" mitotic cell cycle|DNA binding|chromatin binding|protein binding|nucleoplasm|cytoplasm|DNA-dependent DNA replication|DNA repair|nuclear replication fork HMG WDPCP 70.29774855 66.58648849 74.00900861 1.111471866 0.152471431 0.796624056 1 0.227678018 0.248823134 51057 WD repeat containing planar cell polarity effector "GO:0001822,GO:0002093,GO:0005886,GO:0005930,GO:0005938,GO:0007224,GO:0007399,GO:0010762,GO:0016324,GO:0016476,GO:0032185,GO:0032880,GO:0042733,GO:0043010,GO:0043587,GO:0044782,GO:0045184,GO:0051893,GO:0055123,GO:0060021,GO:0060271,GO:0060541,GO:0072359,GO:0090521,GO:0097541,GO:1900027,GO:2000114" kidney development|auditory receptor cell morphogenesis|plasma membrane|axoneme|cell cortex|smoothened signaling pathway|nervous system development|regulation of fibroblast migration|apical plasma membrane|regulation of embryonic cell shape|septin cytoskeleton organization|regulation of protein localization|embryonic digit morphogenesis|camera-type eye development|tongue morphogenesis|cilium organization|establishment of protein localization|regulation of focal adhesion assembly|digestive system development|roof of mouth development|cilium assembly|respiratory system development|circulatory system development|glomerular visceral epithelial cell migration|axonemal basal plate|regulation of ruffle assembly|regulation of establishment of cell polarity WDR1 8823.839916 7783.336256 9864.343576 1.267367007 0.341834364 0.169356016 1 138.7846144 172.947743 9948 WD repeat domain 1 "GO:0002102,GO:0002446,GO:0002576,GO:0005576,GO:0005829,GO:0005886,GO:0005911,GO:0007605,GO:0008360,GO:0030042,GO:0030043,GO:0030054,GO:0030220,GO:0030834,GO:0030836,GO:0030864,GO:0030865,GO:0040011,GO:0042247,GO:0042995,GO:0043297,GO:0045199,GO:0045214,GO:0048713,GO:0051015,GO:0060307,GO:0070062,GO:1990266" podosome|neutrophil mediated immunity|platelet degranulation|extracellular region|cytosol|plasma membrane|cell-cell junction|sensory perception of sound|regulation of cell shape|actin filament depolymerization|actin filament fragmentation|cell junction|platelet formation|regulation of actin filament depolymerization|positive regulation of actin filament depolymerization|cortical actin cytoskeleton|cortical cytoskeleton organization|locomotion|establishment of planar polarity of follicular epithelium|cell projection|apical junction assembly|maintenance of epithelial cell apical/basal polarity|sarcomere organization|regulation of oligodendrocyte differentiation|actin filament binding|regulation of ventricular cardiac muscle cell membrane repolarization|extracellular exosome|neutrophil migration WDR11 1447.596064 1453.458194 1441.733934 0.991933542 -0.01168463 0.964189127 1 16.71732596 16.30499107 55717 WD repeat domain 11 "GO:0005515,GO:0005634,GO:0005737,GO:0005765,GO:0005802,GO:0005829,GO:0005930,GO:0006886,GO:0007507,GO:0008589,GO:0015630,GO:0016020,GO:0031410,GO:0035264,GO:0036064,GO:0060271,GO:0060322,GO:0099041" protein binding|nucleus|cytoplasm|lysosomal membrane|trans-Golgi network|cytosol|axoneme|intracellular protein transport|heart development|regulation of smoothened signaling pathway|microtubule cytoskeleton|membrane|cytoplasmic vesicle|multicellular organism growth|ciliary basal body|cilium assembly|head development|vesicle tethering to Golgi WDR12 1017.748573 1082.030438 953.4667083 0.88118289 -0.182486613 0.458307073 1 7.157408997 6.201447469 55759 WD repeat domain 12 "GO:0000463,GO:0000466,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0007219,GO:0030687,GO:0042273,GO:0043021,GO:0051726,GO:0070545" "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|protein binding|nucleoplasm|nucleolus|rRNA processing|Notch signaling pathway|preribosome, large subunit precursor|ribosomal large subunit biogenesis|ribonucleoprotein complex binding|regulation of cell cycle|PeBoW complex" WDR13 842.9383048 883.3113864 802.5652233 0.908586978 -0.138303466 0.582580188 1 22.95068414 20.50375118 64743 WD repeat domain 13 "GO:0005654,GO:0005886,GO:0034451,GO:1904691,GO:1990841" nucleoplasm|plasma membrane|centriolar satellite|negative regulation of type B pancreatic cell proliferation|promoter-specific chromatin binding WDR18 473.6832681 512.9240441 434.4424921 0.846991864 -0.239579984 0.388458005 1 13.9804972 11.64321813 57418 WD repeat domain 18 "GO:0005515,GO:0005654,GO:0005656,GO:0005730,GO:0005737,GO:0006364,GO:0007275,GO:0030174,GO:0097344" protein binding|nucleoplasm|nuclear pre-replicative complex|nucleolus|cytoplasm|rRNA processing|multicellular organism development|regulation of DNA-dependent DNA replication initiation|Rix1 complex WDR19 1098.009512 1170.465618 1025.553405 0.876192679 -0.190679935 0.435160194 1 14.03405949 12.09077423 57728 WD repeat domain 19 "GO:0000902,GO:0001701,GO:0001750,GO:0005515,GO:0005737,GO:0005856,GO:0005929,GO:0008406,GO:0030326,GO:0030991,GO:0031076,GO:0031514,GO:0032391,GO:0035721,GO:0035735,GO:0042471,GO:0048701,GO:0050877,GO:0055123,GO:0060271,GO:0060830,GO:0060831,GO:0061055,GO:0065003,GO:0097542,GO:0097730,GO:1903441" cell morphogenesis|in utero embryonic development|photoreceptor outer segment|protein binding|cytoplasm|cytoskeleton|cilium|gonad development|embryonic limb morphogenesis|intraciliary transport particle A|embryonic camera-type eye development|motile cilium|photoreceptor connecting cilium|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|ear morphogenesis|embryonic cranial skeleton morphogenesis|nervous system process|digestive system development|cilium assembly|ciliary receptor clustering involved in smoothened signaling pathway|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|myotome development|protein-containing complex assembly|ciliary tip|non-motile cilium|protein localization to ciliary membrane WDR20 412.6209112 385.9935505 439.2482719 1.137967905 0.186459869 0.519246789 1 2.344612607 2.623446958 91833 WD repeat domain 20 "GO:0005515,GO:0005654,GO:0016579" protein binding|nucleoplasm|protein deubiquitination WDR24 295.6725002 305.8816815 285.4633189 0.933247514 -0.099668334 0.76106281 1 4.650810016 4.267726892 84219 WD repeat domain 24 "GO:0005515,GO:0005765,GO:0005829,GO:0006914,GO:0010506,GO:0032008,GO:0034198,GO:0043231,GO:0061700" protein binding|lysosomal membrane|cytosol|autophagy|regulation of autophagy|positive regulation of TOR signaling|cellular response to amino acid starvation|intracellular membrane-bounded organelle|GATOR2 complex hsa04150 mTOR signaling pathway WDR25 214.9309839 217.4465015 212.4154663 0.976863113 -0.033771683 0.937962514 1 5.811076682 5.5816358 79446 WD repeat domain 25 GO:0005515 protein binding WDR26 4007.516412 3834.965571 4180.067253 1.089988208 0.124312528 0.60209667 1 27.78133082 29.77460608 80232 WD repeat domain 26 "GO:0000151,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829" ubiquitin ligase complex|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol WDR27 518.7582185 560.7830827 476.7333542 0.850120784 -0.234260262 0.388917509 1 1.55203871 1.297341653 253769 WD repeat domain 27 "GO:0005515,GO:0005654" protein binding|nucleoplasm WDR3 1274.999987 1325.487286 1224.512688 0.923820772 -0.11431511 0.637063126 1 7.071053612 6.423075569 10885 WD repeat domain 3 "GO:0003723,GO:0005654,GO:0005730,GO:0006364,GO:0030490,GO:0030515,GO:0031965,GO:0032040,GO:0034388" RNA binding|nucleoplasm|nucleolus|rRNA processing|maturation of SSU-rRNA|snoRNA binding|nuclear membrane|small-subunit processome|Pwp2p-containing subcomplex of 90S preribosome hsa03008 Ribosome biogenesis in eukaryotes WDR31 207.960088 223.6889848 192.2311912 0.85936816 -0.21865177 0.547654258 1 2.425410401 2.049442193 114987 WD repeat domain 31 WDR33 1316.517777 1355.659289 1277.376266 0.942254647 -0.085811089 0.723398047 1 4.67009067 4.326779658 55339 WD repeat domain 33 "GO:0000398,GO:0001650,GO:0003723,GO:0005581,GO:0005634,GO:0005654,GO:0005847,GO:0006301,GO:0006369,GO:0006378,GO:0006406,GO:0007283,GO:0031124" "mRNA splicing, via spliceosome|fibrillar center|RNA binding|collagen trimer|nucleus|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|postreplication repair|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA export from nucleus|spermatogenesis|mRNA 3'-end processing" hsa03015 mRNA surveillance pathway WDR35 557.3774494 628.4099851 486.3449137 0.773929322 -0.369726275 0.16579927 1 4.836614643 3.680560544 57539 WD repeat domain 35 "GO:0005515,GO:0005813,GO:0005929,GO:0005930,GO:0009636,GO:0010629,GO:0030991,GO:0032496,GO:0035721,GO:0035735,GO:0036064,GO:0042073,GO:0043065,GO:0043280,GO:0045019,GO:0060271,GO:0061512,GO:0071333,GO:0071356,GO:0090200,GO:0097421,GO:0097542,GO:1905705,GO:1990830" protein binding|centrosome|cilium|axoneme|response to toxic substance|negative regulation of gene expression|intraciliary transport particle A|response to lipopolysaccharide|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of nitric oxide biosynthetic process|cilium assembly|protein localization to cilium|cellular response to glucose stimulus|cellular response to tumor necrosis factor|positive regulation of release of cytochrome c from mitochondria|liver regeneration|ciliary tip|cellular response to paclitaxel|cellular response to leukemia inhibitory factor WDR36 1349.419148 1500.276819 1198.561477 0.798893552 -0.323924809 0.17718616 1 12.47927313 9.802782908 134430 WD repeat domain 36 "GO:0003723,GO:0005654,GO:0005730,GO:0006364,GO:0007601,GO:0008150,GO:0032040,GO:0034388,GO:0050896" RNA binding|nucleoplasm|nucleolus|rRNA processing|visual perception|biological_process|small-subunit processome|Pwp2p-containing subcomplex of 90S preribosome|response to stimulus hsa03008 Ribosome biogenesis in eukaryotes WDR37 258.7277465 256.982229 260.4732641 1.013584733 0.0194667 0.966093847 1 2.669781828 2.660768018 22884 WD repeat domain 37 "GO:0005634,GO:0005737,GO:0030687" "nucleus|cytoplasm|preribosome, large subunit precursor" WDR4 277.8514861 304.8412676 250.8617045 0.82292567 -0.281165968 0.387280302 1 5.390595818 4.361828226 10785 WD repeat domain 4 "GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006400,GO:0006974,GO:0008176,GO:0043527,GO:0106004" protein binding|nucleus|nucleoplasm|chromosome|cytosol|tRNA modification|cellular response to DNA damage stimulus|tRNA (guanine-N7-)-methyltransferase activity|tRNA methyltransferase complex|tRNA (guanine-N7)-methylation WDR41 1526.123389 1471.14523 1581.101548 1.074741987 0.103990354 0.664416667 1 15.16560114 16.02636479 55255 WD repeat domain 41 "GO:0005085,GO:0005515,GO:0005737,GO:0005765,GO:0006914,GO:0010506,GO:0032045,GO:0050790,GO:1990316" guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|lysosomal membrane|autophagy|regulation of autophagy|guanyl-nucleotide exchange factor complex|regulation of catalytic activity|Atg1/ULK1 kinase complex "hsa04140,hsa05014,hsa05022" Autophagy - animal|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases WDR43 1245.857723 1393.114189 1098.601258 0.788593833 -0.342645667 0.155753408 1 21.20591666 16.44302077 23160 WD repeat domain 43 "GO:0000785,GO:0000993,GO:0001650,GO:0003711,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0006364,GO:0034243,GO:0045943,GO:2000036,GO:2000234" chromatin|RNA polymerase II complex binding|fibrillar center|transcription elongation regulator activity|RNA binding|protein binding|nucleoplasm|nucleolus|rRNA processing|regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription by RNA polymerase I|regulation of stem cell population maintenance|positive regulation of rRNA processing hsa03008 Ribosome biogenesis in eukaryotes WDR44 1501.15407 1320.285217 1682.022923 1.273984516 0.349347743 0.143274459 1 16.9704228 21.25827351 54521 WD repeat domain 44 "GO:0005515,GO:0005794,GO:0005829,GO:0010008,GO:0048471" protein binding|Golgi apparatus|cytosol|endosome membrane|perinuclear region of cytoplasm WDR45 1005.362986 1009.201466 1001.524506 0.992393035 -0.011016485 0.968718446 1 25.93126019 25.30337833 11152 WD repeat domain 45 "GO:0000045,GO:0000407,GO:0000422,GO:0005515,GO:0005829,GO:0006497,GO:0006914,GO:0009267,GO:0019898,GO:0019901,GO:0032266,GO:0034045,GO:0034497,GO:0044804,GO:0080025,GO:1901981" "autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|protein binding|cytosol|protein lipidation|autophagy|cellular response to starvation|extrinsic component of membrane|protein kinase binding|phosphatidylinositol-3-phosphate binding|phagophore assembly site membrane|protein localization to phagophore assembly site|autophagy of nucleus|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol phosphate binding" WDR45B 2274.720569 2224.404881 2325.036258 1.045239685 0.063833806 0.788588907 1 42.02208857 43.18816012 56270 WD repeat domain 45B "GO:0000045,GO:0000407,GO:0000422,GO:0005515,GO:0005764,GO:0005829,GO:0006497,GO:0009267,GO:0019898,GO:0032266,GO:0034045,GO:0034497,GO:0044804,GO:0062078,GO:0080025" "autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|protein binding|lysosome|cytosol|protein lipidation|cellular response to starvation|extrinsic component of membrane|phosphatidylinositol-3-phosphate binding|phagophore assembly site membrane|protein localization to phagophore assembly site|autophagy of nucleus|TSC1-TSC2 complex binding|phosphatidylinositol-3,5-bisphosphate binding" WDR46 827.9762208 843.7756588 812.1767828 0.962550619 -0.055065683 0.830408549 1 14.45610148 13.68188528 9277 WD repeat domain 46 "GO:0000462,GO:0003723,GO:0005575,GO:0005654,GO:0005730,GO:0006364,GO:0032040" "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|cellular_component|nucleoplasm|nucleolus|rRNA processing|small-subunit processome" WDR47 919.8653798 896.8367668 942.8939928 1.051355194 0.072250157 0.77416999 1 11.02061477 11.39269484 22911 WD repeat domain 47 "GO:0005515,GO:0005737,GO:0005874,GO:0007275" protein binding|cytoplasm|microtubule|multicellular organism development WDR48 1172.727425 1100.757888 1244.696963 1.13076361 0.177297361 0.465908841 1 11.78207488 13.09980349 57599 WD repeat domain 48 "GO:0000724,GO:0003677,GO:0003690,GO:0003697,GO:0005515,GO:0005634,GO:0005654,GO:0005764,GO:0005770,GO:0006974,GO:0007283,GO:0007338,GO:0016032,GO:0016579,GO:0035264,GO:0036297,GO:0042769,GO:0043130,GO:0043231,GO:0043588,GO:0048568,GO:0048705,GO:0048872,GO:0050679,GO:0072520,GO:1902525,GO:1903003,GO:1905168" "double-strand break repair via homologous recombination|DNA binding|double-stranded DNA binding|single-stranded DNA binding|protein binding|nucleus|nucleoplasm|lysosome|late endosome|cellular response to DNA damage stimulus|spermatogenesis|single fertilization|viral process|protein deubiquitination|multicellular organism growth|interstrand cross-link repair|DNA damage response, detection of DNA damage|ubiquitin binding|intracellular membrane-bounded organelle|skin development|embryonic organ development|skeletal system morphogenesis|homeostasis of number of cells|positive regulation of epithelial cell proliferation|seminiferous tubule development|regulation of protein monoubiquitination|positive regulation of protein deubiquitination|positive regulation of double-strand break repair via homologous recombination" hsa03460 Fanconi anemia pathway WDR5 1406.281449 1416.003294 1396.559604 0.986268612 -0.019947474 0.936742428 1 20.09292563 19.48541086 11091 WD repeat domain 5 "GO:0000123,GO:0001501,GO:0005515,GO:0005634,GO:0005654,GO:0005671,GO:0031175,GO:0035064,GO:0035097,GO:0042393,GO:0042800,GO:0043687,GO:0043966,GO:0043981,GO:0043982,GO:0043984,GO:0044666,GO:0045652,GO:0045722,GO:0048188,GO:0051568,GO:0051571,GO:0051572,GO:0071339" histone acetyltransferase complex|skeletal system development|protein binding|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|neuron projection development|methylated histone binding|histone methyltransferase complex|histone binding|histone methyltransferase activity (H3-K4 specific)|post-translational protein modification|histone H3 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|MLL3/4 complex|regulation of megakaryocyte differentiation|positive regulation of gluconeogenesis|Set1C/COMPASS complex|histone H3-K4 methylation|positive regulation of histone H3-K4 methylation|negative regulation of histone H3-K4 methylation|MLL1 complex hsa04934 Cushing syndrome other WDR53 274.9384501 278.8309205 271.0459796 0.972080066 -0.040852948 0.911378977 1 4.698671854 4.491054565 348793 WD repeat domain 53 WDR54 1233.012294 1169.425204 1296.599385 1.108749307 0.148933203 0.539019903 1 52.48954906 57.22389059 84058 WD repeat domain 54 "GO:0002091,GO:0031982,GO:0042058,GO:0042803,GO:0043408" negative regulation of receptor internalization|vesicle|regulation of epidermal growth factor receptor signaling pathway|protein homodimerization activity|regulation of MAPK cascade WDR55 933.0095619 876.0284892 989.9906347 1.130089543 0.176437089 0.477287274 1 11.15267901 12.39262298 54853 WD repeat domain 55 "GO:0003674,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0008150" molecular_function|nucleoplasm|nucleolus|cytoplasm|rRNA processing|biological_process WDR59 1187.361802 1257.860384 1116.863221 0.887907144 -0.171519286 0.480127123 1 10.65889121 9.30573666 79726 WD repeat domain 59 "GO:0005515,GO:0005765,GO:0032008,GO:0034198,GO:0061700" protein binding|lysosomal membrane|positive regulation of TOR signaling|cellular response to amino acid starvation|GATOR2 complex hsa04150 mTOR signaling pathway WDR5B 200.5532735 218.4869154 182.6196316 0.835837841 -0.258705019 0.481017176 1 2.765056939 2.272465437 54554 WD repeat domain 5B "GO:0042393,GO:0048188,GO:0051568" histone binding|Set1C/COMPASS complex|histone H3-K4 methylation hsa04934 Cushing syndrome WDR6 2080.304755 2179.667084 1980.942425 0.908827976 -0.137920849 0.560570962 1 26.80913257 23.95717627 11180 WD repeat domain 6 "GO:0003723,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007050,GO:0008180,GO:0008285,GO:0010507" RNA binding|protein binding|cytoplasm|cytosol|plasma membrane|cell cycle arrest|COP9 signalosome|negative regulation of cell population proliferation|negative regulation of autophagy WDR61 467.9811134 451.5396251 484.4226018 1.072824122 0.101413581 0.720667886 1 9.250610324 9.758208549 80349 WD repeat domain 61 "GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006366,GO:0006368,GO:0016055,GO:0016567,GO:0016593,GO:0035327,GO:0043928,GO:0045638,GO:0051571,GO:0055087,GO:0080182,GO:2001162" protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|transcription by RNA polymerase II|transcription elongation from RNA polymerase II promoter|Wnt signaling pathway|protein ubiquitination|Cdc73/Paf1 complex|transcriptionally active chromatin|exonucleolytic catabolism of deadenylated mRNA|negative regulation of myeloid cell differentiation|positive regulation of histone H3-K4 methylation|Ski complex|histone H3-K4 trimethylation|positive regulation of histone H3-K79 methylation hsa03018 RNA degradation WDR62 433.191415 421.3676225 445.0152076 1.05612103 0.078775176 0.78777362 1 4.504730683 4.677929808 284403 WD repeat domain 62 "GO:0000922,GO:0005515,GO:0005634,GO:0005813,GO:0005814,GO:0005829,GO:0007052,GO:0007099,GO:0021987,GO:0022008,GO:0034451" spindle pole|protein binding|nucleus|centrosome|centriole|cytosol|mitotic spindle organization|centriole replication|cerebral cortex development|neurogenesis|centriolar satellite WDR7 602.3832027 649.2182628 555.5481426 0.855718599 -0.224791646 0.393657355 1 4.333114741 3.645879743 23335 WD repeat domain 7 GO:0008021 synaptic vesicle WDR70 776.9512812 753.259651 800.6429113 1.062904286 0.088011688 0.731293747 1 18.51685083 19.35229451 55100 WD repeat domain 70 "GO:0005634,GO:0019899,GO:0035861,GO:1903775,GO:2001173" nucleus|enzyme binding|site of double-strand break|regulation of DNA double-strand break processing|regulation of histone H2B conserved C-terminal lysine ubiquitination WDR72 761.7117945 706.4410263 816.9825626 1.156476666 0.209736157 0.408804001 1 4.87476845 5.543219098 256764 WD repeat domain 72 "GO:0005737,GO:0031214,GO:0031410" cytoplasm|biomineral tissue development|cytoplasmic vesicle WDR73 451.7005984 503.5603192 399.8408777 0.794027771 -0.332738629 0.23518661 1 5.041097117 3.935790152 84942 WD repeat domain 73 "GO:0000922,GO:0003674,GO:0005829,GO:0006997,GO:0031122,GO:0032154,GO:0043066" spindle pole|molecular_function|cytosol|nucleus organization|cytoplasmic microtubule organization|cleavage furrow|negative regulation of apoptotic process WDR74 554.6279597 594.076327 515.1795924 0.86719428 -0.205572855 0.443512684 1 14.20464234 12.11205645 54663 WD repeat domain 74 "GO:0000176,GO:0001825,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0016070,GO:0030687,GO:0042273" "nuclear exosome (RNase complex)|blastocyst formation|protein binding|nucleus|nucleoplasm|nucleolus|rRNA processing|RNA metabolic process|preribosome, large subunit precursor|ribosomal large subunit biogenesis" WDR75 1714.933971 1810.320156 1619.547786 0.89461954 -0.160653825 0.499343748 1 22.26116578 19.58201876 84128 WD repeat domain 75 "GO:0003723,GO:0005654,GO:0005730,GO:0006364,GO:0045943,GO:2000234" RNA binding|nucleoplasm|nucleolus|rRNA processing|positive regulation of transcription by RNA polymerase I|positive regulation of rRNA processing hsa03008 Ribosome biogenesis in eukaryotes WDR76 709.9483814 659.6224016 760.2743612 1.152590269 0.204879744 0.424499377 1 8.838271463 10.01644161 79968 WD repeat domain 76 "GO:0000792,GO:0003677,GO:0005515,GO:0005634,GO:0006974,GO:0019899,GO:0090734,GO:2000001" heterochromatin|DNA binding|protein binding|nucleus|cellular response to DNA damage stimulus|enzyme binding|site of DNA damage|regulation of DNA damage checkpoint WDR77 646.5416564 685.6327487 607.4505642 0.885970755 -0.174669017 0.503074418 1 14.68337065 12.79134837 79084 WD repeat domain 77 "GO:0000387,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006357,GO:0007315,GO:0008284,GO:0008327,GO:0030374,GO:0034709,GO:0045495,GO:0045893,GO:0060528,GO:0060770" "spliceosomal snRNP assembly|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|regulation of transcription by RNA polymerase II|pole plasm assembly|positive regulation of cell population proliferation|methyl-CpG binding|nuclear receptor coactivator activity|methylosome|pole plasm|positive regulation of transcription, DNA-templated|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development|negative regulation of epithelial cell proliferation involved in prostate gland development" WDR81 440.1069763 552.4597717 327.754181 0.593263433 -0.753255232 0.007618864 0.537051371 4.161434388 2.427514379 124997 WD repeat domain 81 "GO:0000421,GO:0005515,GO:0005739,GO:0005765,GO:0005789,GO:0005794,GO:0005829,GO:0006511,GO:0007005,GO:0010923,GO:0031313,GO:0031901,GO:0031902,GO:0035014,GO:0035973,GO:0043551,GO:0045022,GO:0050821,GO:0070530" autophagosome membrane|protein binding|mitochondrion|lysosomal membrane|endoplasmic reticulum membrane|Golgi apparatus|cytosol|ubiquitin-dependent protein catabolic process|mitochondrion organization|negative regulation of phosphatase activity|extrinsic component of endosome membrane|early endosome membrane|late endosome membrane|phosphatidylinositol 3-kinase regulator activity|aggrephagy|regulation of phosphatidylinositol 3-kinase activity|early endosome to late endosome transport|protein stabilization|K63-linked polyubiquitin modification-dependent protein binding WDR82 2696.763727 2782.066722 2611.460732 0.938676528 -0.09130001 0.700377567 1 34.56093756 31.89867563 80335 WD repeat domain 82 "GO:0000781,GO:0000785,GO:0003682,GO:0005515,GO:0005730,GO:0035097,GO:0042800,GO:0048188,GO:0051568,GO:0072357,GO:0080182" "chromosome, telomeric region|chromatin|chromatin binding|protein binding|nucleolus|histone methyltransferase complex|histone methyltransferase activity (H3-K4 specific)|Set1C/COMPASS complex|histone H3-K4 methylation|PTW/PP1 phosphatase complex|histone H3-K4 trimethylation" hsa03015 mRNA surveillance pathway WDR83 134.4373021 110.2838716 158.5907327 1.438022899 0.52408665 0.21565056 1 4.053476262 5.731451405 84292 WD repeat domain 83 "GO:0000165,GO:0000375,GO:0000398,GO:0001666,GO:0005515,GO:0005681,GO:0010008,GO:0032496,GO:0043122,GO:0071013,GO:0090594" "MAPK cascade|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|response to hypoxia|protein binding|spliceosomal complex|endosome membrane|response to lipopolysaccharide|regulation of I-kappaB kinase/NF-kappaB signaling|catalytic step 2 spliceosome|inflammatory response to wounding" WDR83OS 848.3687015 824.0077951 872.729608 1.059127854 0.082876757 0.743791609 1 45.38264351 47.26170207 51398 WD repeat domain 83 opposite strand "GO:0005515,GO:0016021" protein binding|integral component of membrane WDR89 344.7801584 383.9127227 305.647594 0.796138226 -0.328909161 0.276371188 1 4.66500829 3.651842808 112840 WD repeat domain 89 WDR90 320.0429685 352.7003062 287.3856308 0.814815371 -0.295454899 0.339726725 1 3.236967688 2.593395518 197335 WD repeat domain 90 "GO:0005515,GO:0005737,GO:0005814,GO:0060271" protein binding|cytoplasm|centriole|cilium assembly WDR91 298.2389364 297.5583704 298.9195023 1.004574336 0.006584323 0.995572598 1 3.383793595 3.342389986 29062 WD repeat domain 91 "GO:0005515,GO:0005829,GO:0006511,GO:0031313,GO:0031901,GO:0031902,GO:0035014,GO:0043551,GO:0045022,GO:1903362" protein binding|cytosol|ubiquitin-dependent protein catabolic process|extrinsic component of endosome membrane|early endosome membrane|late endosome membrane|phosphatidylinositol 3-kinase regulator activity|regulation of phosphatidylinositol 3-kinase activity|early endosome to late endosome transport|regulation of cellular protein catabolic process WDR93 4.042768641 5.202069413 2.883467868 0.554292463 -0.851280704 0.745112452 1 0.056450769 0.030766636 56964 WD repeat domain 93 "GO:0005747,GO:0016651,GO:0022900" "mitochondrial respiratory chain complex I|oxidoreductase activity, acting on NAD(P)H|electron transport chain" WDR97 5.122811487 8.323311061 1.922311912 0.230955193 -2.11431511 0.224307997 1 0.085210016 0.019350383 340390 WD repeat domain 97 WDSUB1 286.9032097 302.7604398 271.0459796 0.895248995 -0.1596391 0.624542989 1 4.431642409 3.901033957 151525 "WD repeat, sterile alpha motif and U-box domain containing 1" "GO:0004842,GO:0016567" ubiquitin-protein transferase activity|protein ubiquitination WDTC1 1082.344781 986.3123607 1178.377202 1.194730239 0.256684905 0.293489031 1 9.631780042 11.31481847 23038 WD and tetratricopeptide repeats 1 "GO:0000122,GO:0001701,GO:0004857,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006006,GO:0008361,GO:0016567,GO:0032869,GO:0035264,GO:0042393,GO:0042826,GO:0043086,GO:0043687,GO:0045717,GO:0055082,GO:0080008" negative regulation of transcription by RNA polymerase II|in utero embryonic development|enzyme inhibitor activity|protein binding|nucleoplasm|cytoplasm|cytosol|glucose metabolic process|regulation of cell size|protein ubiquitination|cellular response to insulin stimulus|multicellular organism growth|histone binding|histone deacetylase binding|negative regulation of catalytic activity|post-translational protein modification|negative regulation of fatty acid biosynthetic process|cellular chemical homeostasis|Cul4-RING E3 ubiquitin ligase complex WEE1 948.9824917 891.6346974 1006.330286 1.128635179 0.174579223 0.481219129 1 11.1257669 12.34680867 7465 WEE1 G2 checkpoint kinase "GO:0000086,GO:0000226,GO:0000287,GO:0004672,GO:0004713,GO:0004715,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0007093,GO:0016301,GO:0018108,GO:0030010,GO:0048812,GO:0051301,GO:2000134" G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|magnesium ion binding|protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitotic cell cycle checkpoint|kinase activity|peptidyl-tyrosine phosphorylation|establishment of cell polarity|neuron projection morphogenesis|cell division|negative regulation of G1/S transition of mitotic cell cycle "hsa04110,hsa05170" Cell cycle|Human immunodeficiency virus 1 infection WFDC10B 3.963510714 3.121241648 4.80577978 1.539701286 0.622650484 0.868565758 1 0.157294552 0.238133958 280664 WAP four-disulfide core domain 10B "GO:0004867,GO:0005515,GO:0005615,GO:0010951,GO:0019731,GO:0045087" serine-type endopeptidase inhibitor activity|protein binding|extracellular space|negative regulation of endopeptidase activity|antibacterial humoral response|innate immune response WFDC2 9.448013289 8.323311061 10.57271552 1.270253561 0.345116509 0.853432744 1 0.783421188 0.978491175 10406 WAP four-disulfide core domain 2 "GO:0004866,GO:0004867,GO:0004869,GO:0005515,GO:0005615,GO:0006508,GO:0007283,GO:0010951,GO:0019731,GO:0019828,GO:0045087,GO:0070062" endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|cysteine-type endopeptidase inhibitor activity|protein binding|extracellular space|proteolysis|spermatogenesis|negative regulation of endopeptidase activity|antibacterial humoral response|aspartic-type endopeptidase inhibitor activity|innate immune response|extracellular exosome WFDC3 27.54139976 29.13158871 25.95121081 0.890827173 -0.16678253 0.870128907 1 1.251770812 1.096451573 140686 WAP four-disulfide core domain 3 "GO:0004867,GO:0005515,GO:0005615,GO:0010951,GO:0019731,GO:0045087" serine-type endopeptidase inhibitor activity|protein binding|extracellular space|negative regulation of endopeptidase activity|antibacterial humoral response|innate immune response WFS1 781.0185875 796.9570341 765.080141 0.960001742 -0.058891071 0.819975468 1 11.23999264 10.60984958 7466 wolframin ER transmembrane glycoprotein "GO:0000122,GO:0001822,GO:0003091,GO:0005515,GO:0005783,GO:0005788,GO:0005789,GO:0006983,GO:0007601,GO:0007605,GO:0022417,GO:0030176,GO:0030425,GO:0030433,GO:0030968,GO:0031398,GO:0031625,GO:0032469,GO:0034976,GO:0036498,GO:0042593,GO:0043069,GO:0043433,GO:0043524,GO:0043687,GO:0044267,GO:0045927,GO:0050821,GO:0050877,GO:0051117,GO:0051247,GO:0051928,GO:0055074,GO:1903892,GO:2000675" negative regulation of transcription by RNA polymerase II|kidney development|renal water homeostasis|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|ER overload response|visual perception|sensory perception of sound|protein maturation by protein folding|integral component of endoplasmic reticulum membrane|dendrite|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|endoplasmic reticulum calcium ion homeostasis|response to endoplasmic reticulum stress|IRE1-mediated unfolded protein response|glucose homeostasis|negative regulation of programmed cell death|negative regulation of DNA-binding transcription factor activity|negative regulation of neuron apoptotic process|post-translational protein modification|cellular protein metabolic process|positive regulation of growth|protein stabilization|nervous system process|ATPase binding|positive regulation of protein metabolic process|positive regulation of calcium ion transport|calcium ion homeostasis|negative regulation of ATF6-mediated unfolded protein response|negative regulation of type B pancreatic cell apoptotic process hsa04141 Protein processing in endoplasmic reticulum WHAMM 398.1192835 396.3976893 399.8408777 1.008686197 0.012477421 0.975378189 1 4.196591178 4.162209344 123720 "WASP homolog associated with actin, golgi membranes and microtubules" "GO:0000139,GO:0003779,GO:0005737,GO:0005829,GO:0005874,GO:0006888,GO:0007015,GO:0007050,GO:0008017,GO:0030032,GO:0030659,GO:0031267,GO:0033116,GO:0034314,GO:0048041,GO:0051127,GO:0071933,GO:0090527,GO:0097320" Golgi membrane|actin binding|cytoplasm|cytosol|microtubule|endoplasmic reticulum to Golgi vesicle-mediated transport|actin filament organization|cell cycle arrest|microtubule binding|lamellipodium assembly|cytoplasmic vesicle membrane|small GTPase binding|endoplasmic reticulum-Golgi intermediate compartment membrane|Arp2/3 complex-mediated actin nucleation|focal adhesion assembly|positive regulation of actin nucleation|Arp2/3 complex binding|actin filament reorganization|plasma membrane tubulation hsa04530 Tight junction WHRN 105.0377571 120.6880104 89.38750391 0.740649412 -0.433137294 0.349838593 1 0.988322434 0.719751393 25861 whirlin "GO:0001895,GO:0001917,GO:0002141,GO:0002142,GO:0005515,GO:0005737,GO:0005884,GO:0005886,GO:0007605,GO:0010628,GO:0021694,GO:0030426,GO:0032391,GO:0032420,GO:0032426,GO:0036064,GO:0042802,GO:0043025,GO:0045184,GO:0045202,GO:0050910,GO:0050953,GO:0060088,GO:0060122,GO:1990075,GO:1990227,GO:1990696" retina homeostasis|photoreceptor inner segment|stereocilia ankle link|stereocilia ankle link complex|protein binding|cytoplasm|actin filament|plasma membrane|sensory perception of sound|positive regulation of gene expression|cerebellar Purkinje cell layer formation|growth cone|photoreceptor connecting cilium|stereocilium|stereocilium tip|ciliary basal body|identical protein binding|neuronal cell body|establishment of protein localization|synapse|detection of mechanical stimulus involved in sensory perception of sound|sensory perception of light stimulus|auditory receptor cell stereocilium organization|inner ear receptor cell stereocilium organization|periciliary membrane compartment|paranodal junction maintenance|USH2 complex WIPF1 16.17107456 20.80827765 11.53387147 0.554292463 -0.851280704 0.373611413 1 0.189311206 0.10317785 7456 WAS/WASL interacting protein family member 1 "GO:0001726,GO:0003779,GO:0005515,GO:0005522,GO:0005829,GO:0005884,GO:0008154,GO:0015629,GO:0017124,GO:0030048,GO:0031410,GO:0038096,GO:0051707,GO:0065003" ruffle|actin binding|protein binding|profilin binding|cytosol|actin filament|actin polymerization or depolymerization|actin cytoskeleton|SH3 domain binding|actin filament-based movement|cytoplasmic vesicle|Fc-gamma receptor signaling pathway involved in phagocytosis|response to other organism|protein-containing complex assembly "hsa04144,hsa05130,hsa05135" Endocytosis|Pathogenic Escherichia coli infection|Yersinia infection WIPF2 1175.783886 1168.38479 1183.182982 1.012665512 0.018157724 0.944081261 1 8.153052936 8.118157267 147179 WAS/WASL interacting protein family member 2 "GO:0003779,GO:0005515,GO:0005654,GO:0005829,GO:0005884,GO:0005886,GO:0030048,GO:0038096" actin binding|protein binding|nucleoplasm|cytosol|actin filament|plasma membrane|actin filament-based movement|Fc-gamma receptor signaling pathway involved in phagocytosis "hsa04144,hsa05130,hsa05135" Endocytosis|Pathogenic Escherichia coli infection|Yersinia infection WIPF3 5.04355356 6.242483296 3.844623824 0.615880514 -0.699277611 0.760739355 1 0.073885531 0.0447432 644150 WAS/WASL interacting protein family member 3 "GO:0003779,GO:0005829,GO:0005884,GO:0007275,GO:0007283,GO:0017124,GO:0030048,GO:0030154,GO:0038096" actin binding|cytosol|actin filament|multicellular organism development|spermatogenesis|SH3 domain binding|actin filament-based movement|cell differentiation|Fc-gamma receptor signaling pathway involved in phagocytosis "hsa04144,hsa05130,hsa05135" Endocytosis|Pathogenic Escherichia coli infection|Yersinia infection WIPI1 1528.352672 1504.438474 1552.266869 1.031791526 0.045151503 0.852335039 1 18.68057616 18.95192819 55062 "WD repeat domain, phosphoinositide interacting 1" "GO:0000045,GO:0000139,GO:0000407,GO:0000421,GO:0000422,GO:0005102,GO:0005515,GO:0005737,GO:0005802,GO:0005829,GO:0005856,GO:0006497,GO:0006914,GO:0009267,GO:0010008,GO:0016236,GO:0019898,GO:0030136,GO:0030331,GO:0032266,GO:0034045,GO:0034497,GO:0036498,GO:0044804,GO:0048203,GO:0050681,GO:0080025" "autophagosome assembly|Golgi membrane|phagophore assembly site|autophagosome membrane|autophagy of mitochondrion|signaling receptor binding|protein binding|cytoplasm|trans-Golgi network|cytosol|cytoskeleton|protein lipidation|autophagy|cellular response to starvation|endosome membrane|macroautophagy|extrinsic component of membrane|clathrin-coated vesicle|estrogen receptor binding|phosphatidylinositol-3-phosphate binding|phagophore assembly site membrane|protein localization to phagophore assembly site|IRE1-mediated unfolded protein response|autophagy of nucleus|vesicle targeting, trans-Golgi to endosome|androgen receptor binding|phosphatidylinositol-3,5-bisphosphate binding" "hsa04136,hsa04140,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022,hsa05131" Autophagy - other|Autophagy - animal|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis WIPI2 3114.816264 2906.916388 3322.71614 1.143038084 0.192873473 0.415688278 1 33.0570605 37.15319029 26100 "WD repeat domain, phosphoinositide interacting 2" "GO:0000045,GO:0000407,GO:0000422,GO:0005515,GO:0005654,GO:0005776,GO:0005829,GO:0006497,GO:0009267,GO:0016020,GO:0016236,GO:0019898,GO:0032266,GO:0032991,GO:0034045,GO:0034497,GO:0044804,GO:0061739,GO:0080025,GO:0097352,GO:0098792" "autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|protein binding|nucleoplasm|autophagosome|cytosol|protein lipidation|cellular response to starvation|membrane|macroautophagy|extrinsic component of membrane|phosphatidylinositol-3-phosphate binding|protein-containing complex|phagophore assembly site membrane|protein localization to phagophore assembly site|autophagy of nucleus|protein lipidation involved in autophagosome assembly|phosphatidylinositol-3,5-bisphosphate binding|autophagosome maturation|xenophagy" "hsa04136,hsa04140,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022,hsa05131" Autophagy - other|Autophagy - animal|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Shigellosis WIZ 628.7307031 659.6224016 597.8390046 0.906335205 -0.14188337 0.589446697 1 3.352970306 2.988062902 58525 WIZ zinc finger "GO:0000978,GO:0000981,GO:0001226,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0010571,GO:0030496,GO:0044877,GO:0046872,GO:0050821,GO:0070062,GO:1990226" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription corepressor binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|positive regulation of nuclear cell cycle DNA replication|midbody|protein-containing complex binding|metal ion binding|protein stabilization|extracellular exosome|histone methyltransferase binding" WLS 1621.435116 1677.147179 1565.723052 0.933563298 -0.09918025 0.678270286 1 28.07599199 25.77211486 79971 Wnt ligand secretion mediator "GO:0000139,GO:0005515,GO:0005769,GO:0005783,GO:0005789,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0006886,GO:0009948,GO:0012505,GO:0016055,GO:0017147,GO:0030177,GO:0030666,GO:0031301,GO:0031410,GO:0031852,GO:0031901,GO:0032590,GO:0032839,GO:0043123,GO:0061355,GO:0061357,GO:0070062,GO:0090263" Golgi membrane|protein binding|early endosome|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|intracellular protein transport|anterior/posterior axis specification|endomembrane system|Wnt signaling pathway|Wnt-protein binding|positive regulation of Wnt signaling pathway|endocytic vesicle membrane|integral component of organelle membrane|cytoplasmic vesicle|mu-type opioid receptor binding|early endosome membrane|dendrite membrane|dendrite cytoplasm|positive regulation of I-kappaB kinase/NF-kappaB signaling|Wnt protein secretion|positive regulation of Wnt protein secretion|extracellular exosome|positive regulation of canonical Wnt signaling pathway WNK1 5335.37126 5778.458704 4892.283816 0.846641651 -0.240176631 0.318490736 1 23.62565852 19.66775234 65125 WNK lysine deficient protein kinase 1 "GO:0002028,GO:0004672,GO:0004674,GO:0004860,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0006469,GO:0006811,GO:0007165,GO:0010766,GO:0010820,GO:0010923,GO:0016020,GO:0018105,GO:0018107,GO:0019869,GO:0019870,GO:0019901,GO:0019902,GO:0030295,GO:0032147,GO:0033633,GO:0034115,GO:0034260,GO:0035556,GO:0038116,GO:0048666,GO:0050794,GO:0050801,GO:0050852,GO:0090263,GO:0097022,GO:0106310,GO:0106311,GO:1903038,GO:1903288,GO:1904062,GO:1990869,GO:2000651" regulation of sodium ion transport|protein kinase activity|protein serine/threonine kinase activity|protein kinase inhibitor activity|protein binding|ATP binding|cytoplasm|cytosol|protein phosphorylation|negative regulation of protein kinase activity|ion transport|signal transduction|negative regulation of sodium ion transport|positive regulation of T cell chemotaxis|negative regulation of phosphatase activity|membrane|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|chloride channel inhibitor activity|potassium channel inhibitor activity|protein kinase binding|phosphatase binding|protein kinase activator activity|activation of protein kinase activity|negative regulation of cell-cell adhesion mediated by integrin|negative regulation of heterotypic cell-cell adhesion|negative regulation of GTPase activity|intracellular signal transduction|chemokine (C-C motif) ligand 21 signaling pathway|neuron development|regulation of cellular process|ion homeostasis|T cell receptor signaling pathway|positive regulation of canonical Wnt signaling pathway|lymphocyte migration into lymph node|protein serine kinase activity|protein threonine kinase activity|negative regulation of leukocyte cell-cell adhesion|positive regulation of potassium ion import across plasma membrane|regulation of cation transmembrane transport|cellular response to chemokine|positive regulation of sodium ion transmembrane transporter activity WNK4 1158.022623 1118.444924 1197.600321 1.070772727 0.098652299 0.686861874 1 11.44570469 12.05066507 65266 WNK lysine deficient protein kinase 4 "GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005923,GO:0006468,GO:0006811,GO:0006821,GO:0008104,GO:0010766,GO:0016020,GO:0019869,GO:0019870,GO:0035556,GO:0050794,GO:0050801,GO:0070294,GO:0072156,GO:0090188,GO:0106310,GO:0106311,GO:1903288,GO:2000651" protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytosol|bicellular tight junction|protein phosphorylation|ion transport|chloride transport|protein localization|negative regulation of sodium ion transport|membrane|chloride channel inhibitor activity|potassium channel inhibitor activity|intracellular signal transduction|regulation of cellular process|ion homeostasis|renal sodium ion absorption|distal tubule morphogenesis|negative regulation of pancreatic juice secretion|protein serine kinase activity|protein threonine kinase activity|positive regulation of potassium ion import across plasma membrane|positive regulation of sodium ion transmembrane transporter activity WNT10B 17.17185948 21.84869154 12.49502743 0.571889049 -0.806192815 0.388176961 1 0.369462773 0.207756033 7480 Wnt family member 10B "GO:0000086,GO:0000122,GO:0002062,GO:0005109,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0006629,GO:0007050,GO:0007224,GO:0008284,GO:0010971,GO:0014835,GO:0016055,GO:0030182,GO:0030501,GO:0030858,GO:0032434,GO:0043065,GO:0045165,GO:0045599,GO:0045669,GO:0045899,GO:0048018,GO:0048641,GO:0048741,GO:0050680,GO:0050821,GO:0050909,GO:0051091,GO:0051885,GO:0060070,GO:0060346,GO:0061196,GO:0071300,GO:0071320,GO:0071374,GO:0071425,GO:0090263,GO:0120163" G2/M transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|chondrocyte differentiation|frizzled binding|cytokine activity|protein binding|extracellular region|extracellular space|lipid metabolic process|cell cycle arrest|smoothened signaling pathway|positive regulation of cell population proliferation|positive regulation of G2/M transition of mitotic cell cycle|myoblast differentiation involved in skeletal muscle regeneration|Wnt signaling pathway|neuron differentiation|positive regulation of bone mineralization|positive regulation of epithelial cell differentiation|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of apoptotic process|cell fate commitment|negative regulation of fat cell differentiation|positive regulation of osteoblast differentiation|positive regulation of RNA polymerase II transcription preinitiation complex assembly|receptor ligand activity|regulation of skeletal muscle tissue development|skeletal muscle fiber development|negative regulation of epithelial cell proliferation|protein stabilization|sensory perception of taste|positive regulation of DNA-binding transcription factor activity|positive regulation of timing of anagen|canonical Wnt signaling pathway|bone trabecula formation|fungiform papilla development|cellular response to retinoic acid|cellular response to cAMP|cellular response to parathyroid hormone stimulus|hematopoietic stem cell proliferation|positive regulation of canonical Wnt signaling pathway|negative regulation of cold-induced thermogenesis "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT11 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.066550112 0.080602113 7481 Wnt family member 11 "GO:0001649,GO:0001837,GO:0003138,GO:0003139,GO:0003151,GO:0003283,GO:0003402,GO:0005096,GO:0005109,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0006468,GO:0007223,GO:0010628,GO:0016055,GO:0030182,GO:0030282,GO:0030295,GO:0030308,GO:0030325,GO:0030335,GO:0030336,GO:0031012,GO:0031667,GO:0032147,GO:0032915,GO:0034394,GO:0043065,GO:0043066,GO:0043547,GO:0045165,GO:0045199,GO:0045892,GO:0045893,GO:0048341,GO:0048570,GO:0048706,GO:0048844,GO:0051496,GO:0060028,GO:0060070,GO:0060071,GO:0060197,GO:0060412,GO:0060484,GO:0060548,GO:0060675,GO:0060775,GO:0061037,GO:0061053,GO:0061101,GO:0062009,GO:0070830,GO:0071260,GO:0071300,GO:0072177,GO:0072201,GO:0090037,GO:0090082,GO:0090090,GO:0090272" "osteoblast differentiation|epithelial to mesenchymal transition|primary heart field specification|secondary heart field specification|outflow tract morphogenesis|atrial septum development|planar cell polarity pathway involved in axis elongation|GTPase activator activity|frizzled binding|cytokine activity|protein binding|extracellular region|extracellular space|cytoplasm|protein phosphorylation|Wnt signaling pathway, calcium modulating pathway|positive regulation of gene expression|Wnt signaling pathway|neuron differentiation|bone mineralization|protein kinase activator activity|negative regulation of cell growth|adrenal gland development|positive regulation of cell migration|negative regulation of cell migration|extracellular matrix|response to nutrient levels|activation of protein kinase activity|positive regulation of transforming growth factor beta2 production|protein localization to cell surface|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of GTPase activity|cell fate commitment|maintenance of epithelial cell apical/basal polarity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|paraxial mesoderm formation|notochord morphogenesis|embryonic skeletal system development|artery morphogenesis|positive regulation of stress fiber assembly|convergent extension involved in axis elongation|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|cloacal septation|ventricular septum morphogenesis|lung-associated mesenchyme development|negative regulation of cell death|ureteric bud morphogenesis|planar cell polarity pathway involved in gastrula mediolateral intercalation|negative regulation of cartilage development|somite development|neuroendocrine cell differentiation|secondary palate development|bicellular tight junction assembly|cellular response to mechanical stimulus|cellular response to retinoic acid|mesonephric duct development|negative regulation of mesenchymal cell proliferation|positive regulation of protein kinase C signaling|positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|negative regulation of fibroblast growth factor production" "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT2B 186.8693772 187.2744989 186.4642555 0.995673498 -0.006255364 1 1 0.815744026 0.798623395 7482 Wnt family member 2B "GO:0002062,GO:0002088,GO:0005109,GO:0005125,GO:0005576,GO:0005615,GO:0008584,GO:0009267,GO:0016055,GO:0021871,GO:0030182,GO:0043231,GO:0045165,GO:0060070,GO:0060492,GO:0060638,GO:0061072,GO:0061303,GO:0062023,GO:0071425,GO:0090190" chondrocyte differentiation|lens development in camera-type eye|frizzled binding|cytokine activity|extracellular region|extracellular space|male gonad development|cellular response to starvation|Wnt signaling pathway|forebrain regionalization|neuron differentiation|intracellular membrane-bounded organelle|cell fate commitment|canonical Wnt signaling pathway|lung induction|mesenchymal-epithelial cell signaling|iris morphogenesis|cornea development in camera-type eye|collagen-containing extracellular matrix|hematopoietic stem cell proliferation|positive regulation of branching involved in ureteric bud morphogenesis "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT3 249.7603112 248.658918 250.8617045 1.008858667 0.012724079 0.983265886 1 4.037258727 4.004866926 7473 Wnt family member 3 "GO:0000902,GO:0001707,GO:0005109,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005796,GO:0005886,GO:0007276,GO:0007411,GO:0009948,GO:0009950,GO:0010628,GO:0016055,GO:0019904,GO:0030177,GO:0030182,GO:0030666,GO:0031012,GO:0035115,GO:0035116,GO:0044338,GO:0044339,GO:0045165,GO:0048018,GO:0048697,GO:0048843,GO:0050767,GO:0060064,GO:0060070,GO:0060174,GO:0060323,GO:0061180,GO:0070062,GO:0071300,GO:0072089,GO:1904954,GO:1905474,GO:1990909" cell morphogenesis|mesoderm formation|frizzled binding|cytokine activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|gamete generation|axon guidance|anterior/posterior axis specification|dorsal/ventral axis specification|positive regulation of gene expression|Wnt signaling pathway|protein domain specific binding|positive regulation of Wnt signaling pathway|neuron differentiation|endocytic vesicle membrane|extracellular matrix|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt signaling pathway involved in osteoblast differentiation|cell fate commitment|receptor ligand activity|positive regulation of collateral sprouting in absence of injury|negative regulation of axon extension involved in axon guidance|regulation of neurogenesis|Spemann organizer formation at the anterior end of the primitive streak|canonical Wnt signaling pathway|limb bud formation|head morphogenesis|mammary gland epithelium development|extracellular exosome|cellular response to retinoic acid|stem cell proliferation|canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|canonical Wnt signaling pathway involved in stem cell proliferation|Wnt signalosome "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05206,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT5A 108.8377216 132.1325631 85.54288008 0.647401958 -0.627266366 0.167432888 1 0.479021265 0.304929878 7474 Wnt family member 5A "GO:0000187,GO:0001736,GO:0001756,GO:0001822,GO:0001837,GO:0001938,GO:0001947,GO:0002053,GO:0002088,GO:0002720,GO:0003138,GO:0003139,GO:0003283,GO:0003323,GO:0003402,GO:0003408,GO:0005109,GO:0005115,GO:0005125,GO:0005515,GO:0005543,GO:0005576,GO:0005615,GO:0005788,GO:0005796,GO:0005886,GO:0006468,GO:0007223,GO:0007257,GO:0007411,GO:0007442,GO:0007494,GO:0008584,GO:0008595,GO:0009986,GO:0010033,GO:0010595,GO:0010628,GO:0010800,GO:0010820,GO:0010976,GO:0016055,GO:0019904,GO:0021891,GO:0030182,GO:0030216,GO:0030324,GO:0030514,GO:0030665,GO:0030666,GO:0030669,GO:0032092,GO:0032148,GO:0032722,GO:0032729,GO:0032731,GO:0032755,GO:0032757,GO:0032760,GO:0033138,GO:0034613,GO:0035567,GO:0036342,GO:0036517,GO:0036518,GO:0038031,GO:0040037,GO:0042060,GO:0042733,GO:0043032,GO:0043066,GO:0043122,GO:0045165,GO:0045198,GO:0045599,GO:0045732,GO:0045766,GO:0045778,GO:0045807,GO:0045836,GO:0045892,GO:0045893,GO:0045944,GO:0046330,GO:0048018,GO:0048022,GO:0048146,GO:0048341,GO:0048570,GO:0048706,GO:0048806,GO:0048843,GO:0048850,GO:0050680,GO:0050727,GO:0050729,GO:0050807,GO:0051092,GO:0051216,GO:0051885,GO:0051964,GO:0060028,GO:0060029,GO:0060065,GO:0060067,GO:0060068,GO:0060070,GO:0060071,GO:0060157,GO:0060324,GO:0060340,GO:0060599,GO:0060638,GO:0060686,GO:0060744,GO:0060750,GO:0060760,GO:0060762,GO:0060775,GO:0060809,GO:0060907,GO:0061024,GO:0061036,GO:0061347,GO:0061348,GO:0061349,GO:0061350,GO:0061354,GO:0062009,GO:0062023,GO:0070062,GO:0070245,GO:0071222,GO:0071277,GO:0071300,GO:0071346,GO:0071425,GO:0071560,GO:0072201,GO:0090009,GO:0090037,GO:0090082,GO:0090090,GO:0090103,GO:0090179,GO:0090630,GO:0097325,GO:0098794,GO:0098978,GO:0099054,GO:0099068,GO:0099175,GO:0099566,GO:0150012,GO:1900020,GO:1901216,GO:1902379,GO:1902474,GO:1903827,GO:1904861,GO:1904862,GO:1904934,GO:1904938,GO:1904953,GO:1904955,GO:2000049,GO:2000052" "activation of MAPK activity|establishment of planar polarity|somitogenesis|kidney development|epithelial to mesenchymal transition|positive regulation of endothelial cell proliferation|heart looping|positive regulation of mesenchymal cell proliferation|lens development in camera-type eye|positive regulation of cytokine production involved in immune response|primary heart field specification|secondary heart field specification|atrial septum development|type B pancreatic cell development|planar cell polarity pathway involved in axis elongation|optic cup formation involved in camera-type eye development|frizzled binding|receptor tyrosine kinase-like orphan receptor binding|cytokine activity|protein binding|phospholipid binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|protein phosphorylation|Wnt signaling pathway, calcium modulating pathway|activation of JUN kinase activity|axon guidance|hindgut morphogenesis|midgut development|male gonad development|anterior/posterior axis specification, embryo|cell surface|response to organic substance|positive regulation of endothelial cell migration|positive regulation of gene expression|positive regulation of peptidyl-threonine phosphorylation|positive regulation of T cell chemotaxis|positive regulation of neuron projection development|Wnt signaling pathway|protein domain specific binding|olfactory bulb interneuron development|neuron differentiation|keratinocyte differentiation|lung development|negative regulation of BMP signaling pathway|clathrin-coated vesicle membrane|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|positive regulation of protein binding|activation of protein kinase B activity|positive regulation of chemokine production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|positive regulation of peptidyl-serine phosphorylation|cellular protein localization|non-canonical Wnt signaling pathway|post-anal tail morphogenesis|chemoattraction of serotonergic neuron axon|chemorepulsion of dopaminergic neuron axon|non-canonical Wnt signaling pathway via JNK cascade|negative regulation of fibroblast growth factor receptor signaling pathway|wound healing|embryonic digit morphogenesis|positive regulation of macrophage activation|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|cell fate commitment|establishment of epithelial cell apical/basal polarity|negative regulation of fat cell differentiation|positive regulation of protein catabolic process|positive regulation of angiogenesis|positive regulation of ossification|positive regulation of endocytosis|positive regulation of meiotic nuclear division|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|receptor ligand activity|negative regulation of melanin biosynthetic process|positive regulation of fibroblast proliferation|paraxial mesoderm formation|notochord morphogenesis|embryonic skeletal system development|genitalia development|negative regulation of axon extension involved in axon guidance|hypophysis morphogenesis|negative regulation of epithelial cell proliferation|regulation of inflammatory response|positive regulation of inflammatory response|regulation of synapse organization|positive regulation of NF-kappaB transcription factor activity|cartilage development|positive regulation of timing of anagen|negative regulation of synapse assembly|convergent extension involved in axis elongation|convergent extension involved in organogenesis|uterus development|cervix development|vagina development|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|urinary bladder development|face development|positive regulation of type I interferon-mediated signaling pathway|lateral sprouting involved in mammary gland duct morphogenesis|mesenchymal-epithelial cell signaling|negative regulation of prostatic bud formation|mammary gland branching involved in thelarche|epithelial cell proliferation involved in mammary gland duct elongation|positive regulation of response to cytokine stimulus|regulation of branching involved in mammary gland duct morphogenesis|planar cell polarity pathway involved in gastrula mediolateral intercalation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of macrophage cytokine production|membrane organization|positive regulation of cartilage development|planar cell polarity pathway involved in outflow tract morphogenesis|planar cell polarity pathway involved in ventricular septum morphogenesis|planar cell polarity pathway involved in cardiac right atrium morphogenesis|planar cell polarity pathway involved in cardiac muscle tissue morphogenesis|planar cell polarity pathway involved in pericardium morphogenesis|secondary palate development|collagen-containing extracellular matrix|extracellular exosome|positive regulation of thymocyte apoptotic process|cellular response to lipopolysaccharide|cellular response to calcium ion|cellular response to retinoic acid|cellular response to interferon-gamma|hematopoietic stem cell proliferation|cellular response to transforming growth factor beta stimulus|negative regulation of mesenchymal cell proliferation|primitive streak formation|positive regulation of protein kinase C signaling|positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|cochlea morphogenesis|planar cell polarity pathway involved in neural tube closure|activation of GTPase activity|melanocyte proliferation|postsynapse|glutamatergic synapse|presynapse assembly|postsynapse assembly|regulation of postsynapse organization|regulation of postsynaptic cytosolic calcium ion concentration|positive regulation of neuron projection arborization|positive regulation of protein kinase C activity|positive regulation of neuron death|chemoattractant activity involved in axon guidance|positive regulation of protein localization to synapse|regulation of cellular protein localization|excitatory synapse assembly|inhibitory synapse assembly|negative regulation of cell proliferation in midbrain|planar cell polarity pathway involved in axon guidance|Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation|positive regulation of cell-cell adhesion mediated by cadherin|positive regulation of non-canonical Wnt signaling pathway" "hsa04150,hsa04310,hsa04360,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Axon guidance|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT5B 1261.931876 1058.100919 1465.762833 1.385276968 0.470174454 0.051360359 1 14.56885999 19.84418933 81029 Wnt family member 5B "GO:0002062,GO:0005102,GO:0005109,GO:0005125,GO:0005576,GO:0005615,GO:0005788,GO:0005796,GO:0005886,GO:0016055,GO:0030182,GO:0030335,GO:0030666,GO:0042060,GO:0042692,GO:0045165,GO:0045444,GO:0060070,GO:0062023,GO:0070062,GO:0070307,GO:0071300,GO:1904105,GO:2000052" chondrocyte differentiation|signaling receptor binding|frizzled binding|cytokine activity|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|Wnt signaling pathway|neuron differentiation|positive regulation of cell migration|endocytic vesicle membrane|wound healing|muscle cell differentiation|cell fate commitment|fat cell differentiation|canonical Wnt signaling pathway|collagen-containing extracellular matrix|extracellular exosome|lens fiber cell development|cellular response to retinoic acid|positive regulation of convergent extension involved in gastrulation|positive regulation of non-canonical Wnt signaling pathway "hsa04150,hsa04310,hsa04360,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Axon guidance|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT7B 636.1029191 651.2990905 620.9067476 0.953335812 -0.068943602 0.796166267 1 8.351426099 7.82848509 7477 Wnt family member 7B "GO:0001701,GO:0003338,GO:0005109,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005796,GO:0005886,GO:0016055,GO:0016332,GO:0021871,GO:0022009,GO:0030182,GO:0030324,GO:0030666,GO:0032364,GO:0042592,GO:0044237,GO:0045165,GO:0045669,GO:0046330,GO:0048018,GO:0048144,GO:0048568,GO:0050808,GO:0060070,GO:0060425,GO:0060428,GO:0060482,GO:0060535,GO:0060560,GO:0060669,GO:0060710,GO:0061180,GO:0070062,GO:0070307,GO:0071300,GO:0072053,GO:0072054,GO:0072060,GO:0072061,GO:0072089,GO:0072205,GO:0072207,GO:0072236" in utero embryonic development|metanephros morphogenesis|frizzled binding|cytokine activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|Wnt signaling pathway|establishment or maintenance of polarity of embryonic epithelium|forebrain regionalization|central nervous system vasculogenesis|neuron differentiation|lung development|endocytic vesicle membrane|oxygen homeostasis|homeostatic process|cellular metabolic process|cell fate commitment|positive regulation of osteoblast differentiation|positive regulation of JNK cascade|receptor ligand activity|fibroblast proliferation|embryonic organ development|synapse organization|canonical Wnt signaling pathway|lung morphogenesis|lung epithelium development|lobar bronchus development|trachea cartilage morphogenesis|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|chorio-allantoic fusion|mammary gland epithelium development|extracellular exosome|lens fiber cell development|cellular response to retinoic acid|renal inner medulla development|renal outer medulla development|outer medullary collecting duct development|inner medullary collecting duct development|stem cell proliferation|metanephric collecting duct development|metanephric epithelium development|metanephric loop of Henle development "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT9A 18.53433549 19.76786377 17.30080721 0.875198626 -0.192317622 0.886403646 1 0.225856253 0.194361358 7483 Wnt family member 9A "GO:0005109,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0007267,GO:0007275,GO:0008285,GO:0016055,GO:0030182,GO:0032331,GO:0045165,GO:0048018,GO:0060070,GO:0061072,GO:0061303,GO:0071300,GO:0072498" frizzled binding|cytokine activity|protein binding|extracellular region|extracellular space|cell-cell signaling|multicellular organism development|negative regulation of cell population proliferation|Wnt signaling pathway|neuron differentiation|negative regulation of chondrocyte differentiation|cell fate commitment|receptor ligand activity|canonical Wnt signaling pathway|iris morphogenesis|cornea development in camera-type eye|cellular response to retinoic acid|embryonic skeletal joint development "hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05010,hsa05022,hsa05165,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WRAP53 379.039589 438.0142446 320.0649333 0.730718093 -0.452613166 0.122859621 1 7.634230959 5.485122533 55135 WD repeat containing antisense to TP53 "GO:0000781,GO:0003723,GO:0005515,GO:0005654,GO:0005697,GO:0005829,GO:0006281,GO:0007004,GO:0015030,GO:0016032,GO:0016604,GO:0030576,GO:0031625,GO:0032203,GO:0034337,GO:0035861,GO:0042393,GO:0042802,GO:0044877,GO:0045739,GO:0051087,GO:0051973,GO:0070034,GO:0090666,GO:0090671,GO:1904851,GO:1904867,GO:1905168,GO:2000781,GO:2001034" "chromosome, telomeric region|RNA binding|protein binding|nucleoplasm|telomerase holoenzyme complex|cytosol|DNA repair|telomere maintenance via telomerase|Cajal body|viral process|nuclear body|Cajal body organization|ubiquitin protein ligase binding|telomere formation via telomerase|RNA folding|site of double-strand break|histone binding|identical protein binding|protein-containing complex binding|positive regulation of DNA repair|chaperone binding|positive regulation of telomerase activity|telomerase RNA binding|scaRNA localization to Cajal body|telomerase RNA localization to Cajal body|positive regulation of establishment of protein localization to telomere|protein localization to Cajal body|positive regulation of double-strand break repair via homologous recombination|positive regulation of double-strand break repair|positive regulation of double-strand break repair via nonhomologous end joining" WRAP73 687.688309 642.9757795 732.4008385 1.139079981 0.18786905 0.466542684 1 20.24450479 22.67423041 49856 "WD repeat containing, antisense to TP73" "GO:0000070,GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0005815,GO:0030030,GO:0036064,GO:0072686,GO:0090307,GO:1902440,GO:1902857,GO:1990811" mitotic sister chromatid segregation|protein binding|cytoplasm|centrosome|centriole|microtubule organizing center|cell projection organization|ciliary basal body|mitotic spindle|mitotic spindle assembly|protein localization to mitotic spindle pole body|positive regulation of non-motile cilium assembly|MWP complex WRN 516.6478226 530.6110801 502.684565 0.947369144 -0.078001411 0.779596732 1 5.260586685 4.900321743 7486 WRN RecQ like helicase "GO:0000287,GO:0000400,GO:0000403,GO:0000405,GO:0000723,GO:0000724,GO:0000731,GO:0000781,GO:0003677,GO:0003678,GO:0003682,GO:0004386,GO:0004527,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005657,GO:0005694,GO:0005730,GO:0005737,GO:0005813,GO:0006259,GO:0006260,GO:0006268,GO:0006281,GO:0006284,GO:0006302,GO:0006310,GO:0006974,GO:0006979,GO:0007420,GO:0007568,GO:0007569,GO:0008408,GO:0009267,GO:0009378,GO:0010225,GO:0010259,GO:0016607,GO:0016887,GO:0030145,GO:0031297,GO:0032405,GO:0032508,GO:0040009,GO:0042803,GO:0042981,GO:0043005,GO:0043138,GO:0044806,GO:0044877,GO:0051345,GO:0051880,GO:0061749,GO:0061820,GO:0061821,GO:0061849,GO:0070337,GO:0071480,GO:0090305,GO:0090399,GO:0090656,GO:0098530,GO:1901796,GO:1902570,GO:1905773" "magnesium ion binding|four-way junction DNA binding|Y-form DNA binding|bubble DNA binding|telomere maintenance|double-strand break repair via homologous recombination|DNA synthesis involved in DNA repair|chromosome, telomeric region|DNA binding|DNA helicase activity|chromatin binding|helicase activity|exonuclease activity|protein binding|ATP binding|nucleus|nucleoplasm|replication fork|chromosome|nucleolus|cytoplasm|centrosome|DNA metabolic process|DNA replication|DNA unwinding involved in DNA replication|DNA repair|base-excision repair|double-strand break repair|DNA recombination|cellular response to DNA damage stimulus|response to oxidative stress|brain development|aging|cell aging|3'-5' exonuclease activity|cellular response to starvation|four-way junction helicase activity|response to UV-C|multicellular organism aging|nuclear speck|ATPase activity|manganese ion binding|replication fork processing|MutLalpha complex binding|DNA duplex unwinding|regulation of growth rate|protein homodimerization activity|regulation of apoptotic process|neuron projection|3'-5' DNA helicase activity|G-quadruplex DNA unwinding|protein-containing complex binding|positive regulation of hydrolase activity|G-quadruplex DNA binding|forked DNA-dependent helicase activity|telomeric D-loop disassembly|telomeric D-loop binding|telomeric G-quadruplex DNA binding|3'-flap-structured DNA binding|cellular response to gamma radiation|nucleic acid phosphodiester bond hydrolysis|replicative senescence|t-circle formation|positive regulation of strand invasion|regulation of signal transduction by p53 class mediator|protein localization to nucleolus|8-hydroxy-2'-deoxyguanosine DNA binding" WRNIP1 1433.951797 1423.286191 1444.617402 1.014987295 0.021461669 0.931572907 1 18.69049413 18.65316655 56897 WRN helicase interacting protein 1 "GO:0000731,GO:0000781,GO:0003677,GO:0005515,GO:0005524,GO:0005634,GO:0006261,GO:0006282,GO:0008047,GO:0016020,GO:0016887,GO:0017116,GO:0030174,GO:0032508,GO:0042802,GO:0045087,GO:0046872,GO:0048471,GO:0050790" "DNA synthesis involved in DNA repair|chromosome, telomeric region|DNA binding|protein binding|ATP binding|nucleus|DNA-dependent DNA replication|regulation of DNA repair|enzyme activator activity|membrane|ATPase activity|single-stranded DNA helicase activity|regulation of DNA-dependent DNA replication initiation|DNA duplex unwinding|identical protein binding|innate immune response|metal ion binding|perinuclear region of cytoplasm|regulation of catalytic activity" other WSB1 4768.404216 4797.348413 4739.460019 0.987933252 -0.017514523 0.942624052 1 59.63793796 57.932384 26118 WD repeat and SOCS box containing 1 "GO:0000209,GO:0005515,GO:0005829,GO:0008150,GO:0035556,GO:0043687" protein polyubiquitination|protein binding|cytosol|biological_process|intracellular signal transduction|post-translational protein modification WSB2 1813.89905 1695.874629 1931.923472 1.139190031 0.188008427 0.428232152 1 30.07833568 33.69156279 55884 WD repeat and SOCS box containing 2 "GO:0005829,GO:0016567,GO:0035556,GO:0043687" cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification WSCD1 1234.697562 1857.138781 612.256344 0.329677217 -1.600873907 9.94E-11 4.53E-07 10.56857362 3.425914267 23302 WSC domain containing 1 "GO:0008146,GO:0016021" sulfotransferase activity|integral component of membrane WTAP 1417.478167 1457.61985 1377.336485 0.944921603 -0.081733456 0.734849611 1 20.07496578 18.65184382 9589 WT1 associated protein "GO:0000381,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006397,GO:0007049,GO:0007275,GO:0008380,GO:0016070,GO:0016607,GO:0031965,GO:0036396,GO:0042802,GO:0080009" "regulation of alternative mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|cytoplasm|mRNA processing|cell cycle|multicellular organism development|RNA splicing|RNA metabolic process|nuclear speck|nuclear membrane|RNA N6-methyladenosine methyltransferase complex|identical protein binding|mRNA methylation" WTIP 259.9367371 238.2547791 281.6186951 1.18200649 0.241237956 0.469831196 1 0.922663063 1.072344119 126374 WT1 interacting protein "GO:0000932,GO:0001666,GO:0003714,GO:0005515,GO:0005634,GO:0005667,GO:0005912,GO:0006355,GO:0007010,GO:0022604,GO:0030030,GO:0035195,GO:0035331,GO:0045892,GO:0046872,GO:2000637" "P-body|response to hypoxia|transcription corepressor activity|protein binding|nucleus|transcription regulator complex|adherens junction|regulation of transcription, DNA-templated|cytoskeleton organization|regulation of cell morphogenesis|cell projection organization|gene silencing by miRNA|negative regulation of hippo signaling|negative regulation of transcription, DNA-templated|metal ion binding|positive regulation of gene silencing by miRNA" "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species WWC1 1862.112906 2103.716871 1620.508942 0.770307528 -0.376493571 0.112031434 1 20.74491924 15.71256434 23286 WW and C2 domain containing 1 "GO:0000122,GO:0003713,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0007221,GO:0016477,GO:0019900,GO:0030010,GO:0032386,GO:0032587,GO:0032991,GO:0035329,GO:0035330,GO:0035331,GO:0043410,GO:0046621,GO:0048471,GO:0060090" negative regulation of transcription by RNA polymerase II|transcription coactivator activity|protein binding|nucleus|cytoplasm|cytosol|positive regulation of transcription of Notch receptor target|cell migration|kinase binding|establishment of cell polarity|regulation of intracellular transport|ruffle membrane|protein-containing complex|hippo signaling|regulation of hippo signaling|negative regulation of hippo signaling|positive regulation of MAPK cascade|negative regulation of organ growth|perinuclear region of cytoplasm|molecular adaptor activity "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species WWC2 1096.924438 1179.829343 1014.019534 0.859462887 -0.218492751 0.370881795 1 8.615944663 7.281170613 80014 WW and C2 domain containing 2 "GO:0000122,GO:0005829,GO:0019900,GO:0035331,GO:0046621,GO:0060090" negative regulation of transcription by RNA polymerase II|cytosol|kinase binding|negative regulation of hippo signaling|negative regulation of organ growth|molecular adaptor activity WWC3 342.3376395 382.8723088 301.8029702 0.788260115 -0.343256317 0.256775207 1 2.939604579 2.278398291 55841 WWC family member 3 "GO:0000122,GO:0005829,GO:0019900,GO:0035331,GO:0046621,GO:0060090" negative regulation of transcription by RNA polymerase II|cytosol|kinase binding|negative regulation of hippo signaling|negative regulation of organ growth|molecular adaptor activity WWOX 117.0522066 120.6880104 113.4164028 0.939748716 -0.089653056 0.857806681 1 2.756053615 2.54665774 51741 WW domain containing oxidoreductase "GO:0000122,GO:0001649,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005794,GO:0005829,GO:0005886,GO:0005902,GO:0016055,GO:0016491,GO:0019899,GO:0030178,GO:0045944,GO:0048705,GO:0055114,GO:0071560,GO:0072332,GO:0090575,GO:0097191,GO:2001238,GO:2001241" negative regulation of transcription by RNA polymerase II|osteoblast differentiation|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|Golgi apparatus|cytosol|plasma membrane|microvillus|Wnt signaling pathway|oxidoreductase activity|enzyme binding|negative regulation of Wnt signaling pathway|positive regulation of transcription by RNA polymerase II|skeletal system morphogenesis|oxidation-reduction process|cellular response to transforming growth factor beta stimulus|intrinsic apoptotic signaling pathway by p53 class mediator|RNA polymerase II transcription regulator complex|extrinsic apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand WWP1 1601.375987 1465.943161 1736.808812 1.184772274 0.244609785 0.304252542 1 20.28907993 23.63569701 11059 WW domain containing E3 ubiquitin protein ligase 1 "GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0007417,GO:0016567,GO:0034220,GO:0043161,GO:0045732,GO:0045892,GO:0046718,GO:0061630,GO:0070062" "ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|signal transduction|central nervous system development|protein ubiquitination|ion transmembrane transport|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of protein catabolic process|negative regulation of transcription, DNA-templated|viral entry into host cell|ubiquitin protein ligase activity|extracellular exosome" "hsa04120,hsa04144" Ubiquitin mediated proteolysis|Endocytosis WWP2 756.3153819 880.1901447 632.440619 0.718527267 -0.476885189 0.059777583 1 8.243968112 5.82439386 11060 WW domain containing E3 ubiquitin protein ligase 2 "GO:0000122,GO:0000151,GO:0000209,GO:0001085,GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006464,GO:0006858,GO:0008134,GO:0010629,GO:0016020,GO:0016567,GO:0032410,GO:0034765,GO:0042391,GO:0043161,GO:0043433,GO:0045732,GO:0045746,GO:0045892,GO:0046718,GO:0051224,GO:0051865,GO:0061630,GO:0070062,GO:0070534,GO:1901016" "negative regulation of transcription by RNA polymerase II|ubiquitin ligase complex|protein polyubiquitination|RNA polymerase II transcription factor binding|ubiquitin-protein transferase activity|protein binding|nucleus|cytoplasm|cytosol|cellular protein modification process|extracellular transport|transcription factor binding|negative regulation of gene expression|membrane|protein ubiquitination|negative regulation of transporter activity|regulation of ion transmembrane transport|regulation of membrane potential|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of DNA-binding transcription factor activity|positive regulation of protein catabolic process|negative regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|viral entry into host cell|negative regulation of protein transport|protein autoubiquitination|ubiquitin protein ligase activity|extracellular exosome|protein K63-linked ubiquitination|regulation of potassium ion transmembrane transporter activity" hsa04120 Ubiquitin mediated proteolysis WWTR1 1000.754122 1216.243829 785.264416 0.645647195 -0.631182056 0.010322719 0.610531935 11.22793596 7.127978381 25937 WW domain containing transcription regulator 1 "GO:0000122,GO:0001649,GO:0001894,GO:0001933,GO:0003015,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006367,GO:0006469,GO:0008284,GO:0010718,GO:0016567,GO:0016604,GO:0017145,GO:0031146,GO:0032835,GO:0035264,GO:0035329,GO:0042803,GO:0045599,GO:0045669,GO:0045944,GO:0048762,GO:0060271,GO:0060390,GO:0060993,GO:0072307,GO:0090090,GO:1900182" "negative regulation of transcription by RNA polymerase II|osteoblast differentiation|tissue homeostasis|negative regulation of protein phosphorylation|heart process|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|plasma membrane|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|negative regulation of protein kinase activity|positive regulation of cell population proliferation|positive regulation of epithelial to mesenchymal transition|protein ubiquitination|nuclear body|stem cell division|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|glomerulus development|multicellular organism growth|hippo signaling|protein homodimerization activity|negative regulation of fat cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|mesenchymal cell differentiation|cilium assembly|regulation of SMAD protein signal transduction|kidney morphogenesis|regulation of metanephric nephron tubule epithelial cell differentiation|negative regulation of canonical Wnt signaling pathway|positive regulation of protein localization to nucleus" "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species XAB2 1396.962384 1385.831292 1408.093476 1.016064137 0.022991472 0.926659607 1 27.94078919 27.91457178 56949 XPA binding protein 2 "GO:0000349,GO:0000398,GO:0000974,GO:0001824,GO:0005515,GO:0005634,GO:0005654,GO:0006283,GO:0006351,GO:0016020,GO:0021987,GO:0043231,GO:0071007,GO:0071013,GO:0071014" "generation of catalytic spliceosome for first transesterification step|mRNA splicing, via spliceosome|Prp19 complex|blastocyst development|protein binding|nucleus|nucleoplasm|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|membrane|cerebral cortex development|intracellular membrane-bounded organelle|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|post-mRNA release spliceosomal complex" hsa03040 Spliceosome XAF1 2.561405743 4.161655531 0.961155956 0.230955193 -2.11431511 0.482263142 1 0.044868668 0.010189247 54739 XIAP associated factor 1 "GO:0005515,GO:0005654,GO:0005739,GO:0005829,GO:0006915,GO:0008270,GO:0035456,GO:0060337" protein binding|nucleoplasm|mitochondrion|cytosol|apoptotic process|zinc ion binding|response to interferon-beta|type I interferon signaling pathway XAGE1A 3.482932736 3.121241648 3.844623824 1.231761029 0.300722389 1 1 0.202892729 0.245733361 653220 X antigen family member 1A GO:0005515 protein binding XAGE1B 6.965865472 6.242483296 7.689247648 1.231761029 0.300722389 0.937576592 1 0.412314184 0.499373984 653067 X antigen family member 1B GO:0005515 protein binding XBP1 2806.652538 2790.390033 2822.915043 1.01165608 0.016718919 0.945255186 1 81.95816596 81.52603215 7494 X-box binding protein 1 "GO:0000977,GO:0000978,GO:0000981,GO:0000987,GO:0001525,GO:0001889,GO:0002639,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0006366,GO:0006511,GO:0006633,GO:0006914,GO:0006915,GO:0006955,GO:0006990,GO:0007517,GO:0008284,GO:0010832,GO:0015031,GO:0016021,GO:0030335,GO:0030968,GO:0031670,GO:0032755,GO:0032869,GO:0035356,GO:0035470,GO:0036498,GO:0036500,GO:0042149,GO:0042632,GO:0043066,GO:0045348,GO:0045579,GO:0045582,GO:0045600,GO:0045766,GO:0045944,GO:0046982,GO:0048666,GO:0055089,GO:0055092,GO:0060612,GO:0071222,GO:0071230,GO:0071332,GO:0071333,GO:0071353,GO:0071375,GO:1900100,GO:1900103,GO:1902236,GO:1903489,GO:1990418,GO:1990837,GO:2000347" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|angiogenesis|liver development|positive regulation of immunoglobulin production|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|transcription by RNA polymerase II|ubiquitin-dependent protein catabolic process|fatty acid biosynthetic process|autophagy|apoptotic process|immune response|positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|muscle organ development|positive regulation of cell population proliferation|negative regulation of myotube differentiation|protein transport|integral component of membrane|positive regulation of cell migration|endoplasmic reticulum unfolded protein response|cellular response to nutrient|positive regulation of interleukin-6 production|cellular response to insulin stimulus|cellular triglyceride homeostasis|positive regulation of vascular wound healing|IRE1-mediated unfolded protein response|ATF6-mediated unfolded protein response|cellular response to glucose starvation|cholesterol homeostasis|negative regulation of apoptotic process|positive regulation of MHC class II biosynthetic process|positive regulation of B cell differentiation|positive regulation of T cell differentiation|positive regulation of fat cell differentiation|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|neuron development|fatty acid homeostasis|sterol homeostasis|adipose tissue development|cellular response to lipopolysaccharide|cellular response to amino acid stimulus|cellular response to fructose stimulus|cellular response to glucose stimulus|cellular response to interleukin-4|cellular response to peptide hormone stimulus|positive regulation of plasma cell differentiation|positive regulation of endoplasmic reticulum unfolded protein response|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of lactation|response to insulin-like growth factor stimulus|sequence-specific double-stranded DNA binding|positive regulation of hepatocyte proliferation" "hsa04141,hsa04932,hsa05010,hsa05012,hsa05014,hsa05017,hsa05022" Protein processing in endoplasmic reticulum|Non-alcoholic fatty liver disease|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases TF_bZIP XDH 545.3787056 490.0349387 600.7224725 1.22587682 0.29381402 0.273811236 1 4.244808316 5.116536719 7498 xanthine dehydrogenase "GO:0001933,GO:0001937,GO:0004854,GO:0004855,GO:0005506,GO:0005515,GO:0005615,GO:0005777,GO:0005829,GO:0006151,GO:0006195,GO:0006919,GO:0007595,GO:0009055,GO:0009115,GO:0010629,GO:0016529,GO:0022900,GO:0042803,GO:0043546,GO:0045602,GO:0046038,GO:0046055,GO:0050660,GO:0051537,GO:0051898,GO:0070674,GO:0070675,GO:0071949,GO:1900745,GO:1900747,GO:2000379,GO:2001213" "negative regulation of protein phosphorylation|negative regulation of endothelial cell proliferation|xanthine dehydrogenase activity|xanthine oxidase activity|iron ion binding|protein binding|extracellular space|peroxisome|cytosol|xanthine oxidation|purine nucleotide catabolic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|lactation|electron transfer activity|xanthine catabolic process|negative regulation of gene expression|sarcoplasmic reticulum|electron transport chain|protein homodimerization activity|molybdopterin cofactor binding|negative regulation of endothelial cell differentiation|GMP catabolic process|dGMP catabolic process|flavin adenine dinucleotide binding|2 iron, 2 sulfur cluster binding|negative regulation of protein kinase B signaling|hypoxanthine dehydrogenase activity|hypoxanthine oxidase activity|FAD binding|positive regulation of p38MAPK cascade|negative regulation of vascular endothelial growth factor signaling pathway|positive regulation of reactive oxygen species metabolic process|negative regulation of vasculogenesis" "hsa00230,hsa00232,hsa00983,hsa04146" Purine metabolism|Caffeine metabolism|Drug metabolism - other enzymes|Peroxisome XIAP 3089.71051 3194.07062 2985.350399 0.934653849 -0.097495936 0.681324567 1 19.42140578 17.84853765 331 X-linked inhibitor of apoptosis "GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005876,GO:0006974,GO:0016055,GO:0016567,GO:0030510,GO:0031398,GO:0042127,GO:0042802,GO:0043027,GO:0043066,GO:0043154,GO:0045088,GO:0046872,GO:0050727,GO:0051402,GO:0051726,GO:0055070,GO:0061630,GO:0070424,GO:0090263,GO:1902530" ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|spindle microtubule|cellular response to DNA damage stimulus|Wnt signaling pathway|protein ubiquitination|regulation of BMP signaling pathway|positive regulation of protein ubiquitination|regulation of cell population proliferation|identical protein binding|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of innate immune response|metal ion binding|regulation of inflammatory response|neuron apoptotic process|regulation of cell cycle|copper ion homeostasis|ubiquitin protein ligase activity|regulation of nucleotide-binding oligomerization domain containing signaling pathway|positive regulation of canonical Wnt signaling pathway|positive regulation of protein linear polyubiquitination "hsa01524,hsa04064,hsa04120,hsa04210,hsa04215,hsa04217,hsa04510,hsa04621,hsa05145,hsa05166,hsa05200,hsa05222" Platinum drug resistance|NF-kappa B signaling pathway|Ubiquitin mediated proteolysis|Apoptosis|Apoptosis - multiple species|Necroptosis|Focal adhesion|NOD-like receptor signaling pathway|Toxoplasmosis|Human T-cell leukemia virus 1 infection|Pathways in cancer|Small cell lung cancer XIRP2 7.203639252 12.48496659 1.922311912 0.153970129 -2.699277611 0.067487328 1 0.051348622 0.007773855 129446 xin actin binding repeat containing 2 "GO:0001725,GO:0005925,GO:0007507,GO:0008150,GO:0030036,GO:0051015" stress fiber|focal adhesion|heart development|biological_process|actin cytoskeleton organization|actin filament binding XK 8.526486296 9.363724944 7.689247648 0.821174019 -0.284240111 0.913967262 1 0.045829493 0.037004235 7504 X-linked Kx blood group "GO:0005215,GO:0005515,GO:0005886,GO:0006865,GO:0016021" transporter activity|protein binding|plasma membrane|amino acid transport|integral component of membrane XKR3 4.483717655 4.161655531 4.80577978 1.154775965 0.207612985 1 1 0.100817025 0.114472929 150165 XK related 3 "GO:0005886,GO:0016021" plasma membrane|integral component of membrane XKR4 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.00822958 0 114786 XK related 4 "GO:0005886,GO:0016020,GO:0016021,GO:0043652,GO:0070782,GO:1902742" plasma membrane|membrane|integral component of membrane|engulfment of apoptotic cell|phosphatidylserine exposure on apoptotic cell surface|apoptotic process involved in development XKR6 24.62333335 15.60620824 33.64045846 2.155581801 1.108077311 0.161928887 1 0.106098682 0.224877329 286046 XK related 6 "GO:0005886,GO:0016020,GO:0016021,GO:0043652,GO:0070782,GO:1902742" plasma membrane|membrane|integral component of membrane|engulfment of apoptotic cell|phosphatidylserine exposure on apoptotic cell surface|apoptotic process involved in development XKR8 176.3463515 163.3449796 189.3477233 1.159189121 0.213115961 0.584312363 1 3.505195555 3.995192664 55113 XK related 8 "GO:0002513,GO:0005886,GO:0016020,GO:0016021,GO:0043652,GO:0051649,GO:0070782,GO:1902742" tolerance induction to self antigen|plasma membrane|membrane|integral component of membrane|engulfment of apoptotic cell|establishment of localization in cell|phosphatidylserine exposure on apoptotic cell surface|apoptotic process involved in development XKR9 36.94978409 36.41448589 37.48508228 1.029400289 0.041804092 0.99682426 1 0.390706511 0.395463233 389668 XK related 9 "GO:0005886,GO:0016020,GO:0016021,GO:0043652,GO:0070782,GO:1902742" plasma membrane|membrane|integral component of membrane|engulfment of apoptotic cell|phosphatidylserine exposure on apoptotic cell surface|apoptotic process involved in development XKRX 4.122026567 7.282897178 0.961155956 0.131974396 -2.921670032 0.166282975 1 0.072500436 0.00940809 402415 XK related X-linked "GO:0005886,GO:0016021" plasma membrane|integral component of membrane XPA 211.8097422 211.2040182 212.4154663 1.005735914 0.008251532 0.996784925 1 4.098752827 4.053282433 7507 "XPA, DNA damage recognition and repair factor" "GO:0000110,GO:0000715,GO:0000717,GO:0003684,GO:0005515,GO:0005634,GO:0005654,GO:0005662,GO:0005737,GO:0006281,GO:0006283,GO:0006284,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0009650,GO:0010996,GO:0019904,GO:0033683,GO:0034504,GO:0042803,GO:0045171,GO:0046872,GO:0070911,GO:0070914,GO:1901255,GO:1990837" "nucleotide-excision repair factor 1 complex|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|damaged DNA binding|protein binding|nucleus|nucleoplasm|DNA replication factor A complex|cytoplasm|DNA repair|transcription-coupled nucleotide-excision repair|base-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|UV protection|response to auditory stimulus|protein domain specific binding|nucleotide-excision repair, DNA incision|protein localization to nucleus|protein homodimerization activity|intercellular bridge|metal ion binding|global genome nucleotide-excision repair|UV-damage excision repair|nucleotide-excision repair involved in interstrand cross-link repair|sequence-specific double-stranded DNA binding" "hsa01524,hsa03420" Platinum drug resistance|Nucleotide excision repair XPC 1057.442817 1165.263549 949.6220845 0.814941895 -0.295230895 0.227537926 1 16.34375136 13.0963288 7508 "XPC complex subunit, DNA damage recognition and repair factor" "GO:0000109,GO:0000111,GO:0000404,GO:0000405,GO:0000715,GO:0000717,GO:0000720,GO:0003684,GO:0003697,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006281,GO:0006289,GO:0006294,GO:0006298,GO:0010224,GO:0010996,GO:0031573,GO:0042493,GO:0043231,GO:0044877,GO:0045893,GO:0070911,GO:0070914,GO:0071942,GO:0090734,GO:1901990,GO:1990731" "nucleotide-excision repair complex|nucleotide-excision repair factor 2 complex|heteroduplex DNA loop binding|bubble DNA binding|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|pyrimidine dimer repair by nucleotide-excision repair|damaged DNA binding|single-stranded DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|cytosol|plasma membrane|DNA repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|mismatch repair|response to UV-B|response to auditory stimulus|intra-S DNA damage checkpoint|response to drug|intracellular membrane-bounded organelle|protein-containing complex binding|positive regulation of transcription, DNA-templated|global genome nucleotide-excision repair|UV-damage excision repair|XPC complex|site of DNA damage|regulation of mitotic cell cycle phase transition|UV-damage excision repair, DNA incision" hsa03420 Nucleotide excision repair XPNPEP1 1072.648933 996.7164996 1148.581367 1.152365159 0.204597947 0.403254387 1 18.0498567 20.45196572 7511 X-prolyl aminopeptidase 1 "GO:0004177,GO:0005737,GO:0005829,GO:0006508,GO:0010815,GO:0030145,GO:0042803,GO:0070006,GO:0070062" aminopeptidase activity|cytoplasm|cytosol|proteolysis|bradykinin catabolic process|manganese ion binding|protein homodimerization activity|metalloaminopeptidase activity|extracellular exosome XPNPEP3 666.9637053 691.875232 642.0521786 0.927988384 -0.107821348 0.680012773 1 4.009567762 3.658569219 63929 X-prolyl aminopeptidase 3 "GO:0003094,GO:0004177,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0006508,GO:0008233,GO:0016485,GO:0030145,GO:0042803,GO:0070006" glomerular filtration|aminopeptidase activity|protein binding|cytoplasm|mitochondrion|cytosol|proteolysis|peptidase activity|protein processing|manganese ion binding|protein homodimerization activity|metalloaminopeptidase activity XPO1 6699.394487 6715.871612 6682.917362 0.995093079 -0.007096616 0.97744162 1 71.31192294 69.774548 7514 exportin 1 "GO:0000054,GO:0000055,GO:0000056,GO:0000776,GO:0003723,GO:0005049,GO:0005515,GO:0005634,GO:0005635,GO:0005642,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006611,GO:0006913,GO:0015030,GO:0016020,GO:0016032,GO:0031965,GO:0032434,GO:0032991,GO:0042254,GO:0043231,GO:0043488,GO:0043657,GO:0051028,GO:0075733,GO:1990904" ribosomal subunit export from nucleus|ribosomal large subunit export from nucleus|ribosomal small subunit export from nucleus|kinetochore|RNA binding|nuclear export signal receptor activity|protein binding|nucleus|nuclear envelope|annulate lamellae|nucleoplasm|nucleolus|cytoplasm|cytosol|protein export from nucleus|nucleocytoplasmic transport|Cajal body|membrane|viral process|nuclear membrane|regulation of proteasomal ubiquitin-dependent protein catabolic process|protein-containing complex|ribosome biogenesis|intracellular membrane-bounded organelle|regulation of mRNA stability|host cell|mRNA transport|intracellular transport of virus|ribonucleoprotein complex "hsa03008,hsa03013,hsa05164,hsa05166" Ribosome biogenesis in eukaryotes|RNA transport|Influenza A|Human T-cell leukemia virus 1 infection XPO4 1017.252904 1119.485338 915.0204701 0.817358155 -0.290959709 0.235941606 1 3.997114802 3.212404314 64328 exportin 4 "GO:0005049,GO:0005515,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0006611,GO:0046827" nuclear export signal receptor activity|protein binding|nuclear pore|nucleoplasm|cytoplasm|cytosol|protein export from nucleus|positive regulation of protein export from nucleus XPO5 1180.633096 1358.780531 1002.485662 0.737783358 -0.438730849 0.070316787 1 13.62307338 9.882689005 57510 exportin 5 "GO:0000049,GO:0003723,GO:0003729,GO:0005049,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006405,GO:0006611,GO:0010586,GO:0016032,GO:0016442,GO:0031267,GO:0035281,GO:0042565,GO:0070883,GO:1900370,GO:1905172" tRNA binding|RNA binding|mRNA binding|nuclear export signal receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|RNA export from nucleus|protein export from nucleus|miRNA metabolic process|viral process|RISC complex|small GTPase binding|pre-miRNA export from nucleus|RNA nuclear export complex|pre-miRNA binding|positive regulation of RNA interference|RISC complex binding hsa03013 RNA transport XPO6 3500.36948 3579.023756 3421.715203 0.956047078 -0.064846434 0.78557586 1 31.61826186 29.72271306 23214 exportin 6 "GO:0005049,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006611,GO:0032991" nuclear export signal receptor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|protein export from nucleus|protein-containing complex XPO7 2474.781975 2669.702023 2279.861928 0.853976177 -0.22773227 0.335457047 1 29.25607603 24.56591869 23039 exportin 7 "GO:0005049,GO:0005515,GO:0005634,GO:0005643,GO:0005737,GO:0006611" nuclear export signal receptor activity|protein binding|nucleus|nuclear pore|cytoplasm|protein export from nucleus XPOT 5095.964169 5776.377876 4415.550462 0.764415098 -0.387571821 0.106895793 1 46.27359212 34.78032606 11260 exportin for tRNA "GO:0000049,GO:0005515,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0006409,GO:0016363,GO:0071528" tRNA binding|protein binding|nuclear pore|nucleoplasm|cytoplasm|cytosol|tRNA export from nucleus|nuclear matrix|tRNA re-export from nucleus hsa03013 RNA transport XPR1 1454.353109 1580.388688 1328.317531 0.840500531 -0.250679364 0.294440735 1 7.928411321 6.552323689 9213 xenotropic and polytropic retrovirus receptor 1 "GO:0000822,GO:0001618,GO:0004888,GO:0004930,GO:0005737,GO:0005794,GO:0005886,GO:0006817,GO:0007186,GO:0009615,GO:0015114,GO:0015562,GO:0016021,GO:0016036,GO:0030643,GO:0031226,GO:0035435,GO:0038023,GO:0046718" inositol hexakisphosphate binding|virus receptor activity|transmembrane signaling receptor activity|G protein-coupled receptor activity|cytoplasm|Golgi apparatus|plasma membrane|phosphate ion transport|G protein-coupled receptor signaling pathway|response to virus|phosphate ion transmembrane transporter activity|efflux transmembrane transporter activity|integral component of membrane|cellular response to phosphate starvation|cellular phosphate ion homeostasis|intrinsic component of plasma membrane|phosphate ion transmembrane transport|signaling receptor activity|viral entry into host cell XRCC1 1015.524935 935.3320805 1095.71779 1.171474616 0.228325694 0.353012062 1 24.32600101 28.02042909 7515 X-ray repair cross complementing 1 "GO:0000012,GO:0000724,GO:0000781,GO:0000785,GO:0001666,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006283,GO:0006284,GO:0006288,GO:0006297,GO:0006303,GO:0010033,GO:0010836,GO:0019899,GO:0021587,GO:0021766,GO:0032356,GO:0033194,GO:0042493,GO:0050882,GO:0061819,GO:0070522,GO:1903518,GO:1904877,GO:1905765,GO:1990414,GO:1990599" "single strand break repair|double-strand break repair via homologous recombination|chromosome, telomeric region|chromatin|response to hypoxia|protein binding|nucleus|nucleoplasm|nucleolus|transcription-coupled nucleotide-excision repair|base-excision repair|base-excision repair, DNA ligation|nucleotide-excision repair, DNA gap filling|double-strand break repair via nonhomologous end joining|response to organic substance|negative regulation of protein ADP-ribosylation|enzyme binding|cerebellum morphogenesis|hippocampus development|oxidized DNA binding|response to hydroperoxide|response to drug|voluntary musculoskeletal movement|telomeric DNA-containing double minutes formation|ERCC4-ERCC1 complex|positive regulation of single strand break repair|positive regulation of DNA ligase activity|negative regulation of protection from non-homologous end joining at telomere|replication-born double-strand break repair via sister chromatid exchange|3' overhang single-stranded DNA endodeoxyribonuclease activity" hsa03410 Base excision repair XRCC2 623.2260789 704.3601985 542.0919592 0.769623213 -0.377775781 0.147846439 1 7.87893717 5.962343243 7516 X-ray repair cross complementing 2 "GO:0000278,GO:0000400,GO:0000724,GO:0001701,GO:0001756,GO:0005515,GO:0005524,GO:0005654,GO:0005657,GO:0005737,GO:0005813,GO:0006281,GO:0007098,GO:0008094,GO:0010165,GO:0010332,GO:0033063,GO:0035264,GO:0042148,GO:0043231,GO:0043524,GO:0050769,GO:0051321,GO:2000269" mitotic cell cycle|four-way junction DNA binding|double-strand break repair via homologous recombination|in utero embryonic development|somitogenesis|protein binding|ATP binding|nucleoplasm|replication fork|cytoplasm|centrosome|DNA repair|centrosome cycle|DNA-dependent ATPase activity|response to X-ray|response to gamma radiation|Rad51B-Rad51C-Rad51D-XRCC2 complex|multicellular organism growth|strand invasion|intracellular membrane-bounded organelle|negative regulation of neuron apoptotic process|positive regulation of neurogenesis|meiotic cell cycle|regulation of fibroblast apoptotic process hsa03440 Homologous recombination XRCC3 628.84959 662.7436432 594.9555368 0.897715946 -0.155669073 0.553231024 1 13.55149815 11.96182456 7517 X-ray repair cross complementing 3 "GO:0000400,GO:0000722,GO:0000724,GO:0000781,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005657,GO:0005737,GO:0005739,GO:0005829,GO:0006281,GO:0006310,GO:0006974,GO:0008094,GO:0008821,GO:0010033,GO:0010824,GO:0033065,GO:0036297,GO:0045003,GO:0048471,GO:0071140,GO:0090267,GO:0090656,GO:0090657,GO:0090737" "four-way junction DNA binding|telomere maintenance via recombination|double-strand break repair via homologous recombination|chromosome, telomeric region|protein binding|ATP binding|nucleus|nucleoplasm|replication fork|cytoplasm|mitochondrion|cytosol|DNA repair|DNA recombination|cellular response to DNA damage stimulus|DNA-dependent ATPase activity|crossover junction endodeoxyribonuclease activity|response to organic substance|regulation of centrosome duplication|Rad51C-XRCC3 complex|interstrand cross-link repair|double-strand break repair via synthesis-dependent strand annealing|perinuclear region of cytoplasm|resolution of mitotic recombination intermediates|positive regulation of mitotic cell cycle spindle assembly checkpoint|t-circle formation|telomeric loop disassembly|telomere maintenance via telomere trimming" hsa03440 Homologous recombination XRCC4 357.7809158 321.4878897 394.073942 1.225781607 0.293701962 0.326650865 1 5.092673733 6.138045909 7518 X-ray repair cross complementing 4 "GO:0000793,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005958,GO:0006302,GO:0006303,GO:0008022,GO:0010165,GO:0016874,GO:0032807,GO:0033152,GO:0035861,GO:0042802,GO:0051103,GO:0051351,GO:0070419,GO:0071285,GO:0075713,GO:1990166" condensed chromosome|DNA binding|protein binding|nucleus|nucleoplasm|cytosol|DNA-dependent protein kinase-DNA ligase 4 complex|double-strand break repair|double-strand break repair via nonhomologous end joining|protein C-terminus binding|response to X-ray|ligase activity|DNA ligase IV complex|immunoglobulin V(D)J recombination|site of double-strand break|identical protein binding|DNA ligation involved in DNA repair|positive regulation of ligase activity|nonhomologous end joining complex|cellular response to lithium ion|establishment of integrated proviral latency|protein localization to site of double-strand break hsa03450 Non-homologous end-joining other XRCC5 11461.64788 10279.28916 12644.0066 1.230046787 0.298713192 0.240961815 1 162.3518112 196.3586092 7520 X-ray repair cross complementing 5 "GO:0000723,GO:0000781,GO:0000783,GO:0000976,GO:0002218,GO:0003677,GO:0003678,GO:0003684,GO:0003690,GO:0003691,GO:0003723,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0006302,GO:0006303,GO:0006310,GO:0006974,GO:0007420,GO:0008022,GO:0008047,GO:0008094,GO:0008283,GO:0016020,GO:0031625,GO:0032040,GO:0032204,GO:0032212,GO:0032481,GO:0032508,GO:0032991,GO:0032993,GO:0034462,GO:0034511,GO:0034774,GO:0042162,GO:0042493,GO:0043085,GO:0043312,GO:0043564,GO:0044877,GO:0045027,GO:0045087,GO:0045860,GO:0045892,GO:0048660,GO:0050769,GO:0051575,GO:0051973,GO:0060218,GO:0070198,GO:0070419,GO:0071398,GO:0071475,GO:0071480,GO:0071481,GO:0075713,GO:0090734,GO:1904430,GO:1990830,GO:1990904" "telomere maintenance|chromosome, telomeric region|nuclear telomere cap complex|transcription regulatory region sequence-specific DNA binding|activation of innate immune response|DNA binding|DNA helicase activity|damaged DNA binding|double-stranded DNA binding|double-stranded telomeric DNA binding|RNA binding|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|nucleolus|cytosol|plasma membrane|double-strand break repair|double-strand break repair via nonhomologous end joining|DNA recombination|cellular response to DNA damage stimulus|brain development|protein C-terminus binding|enzyme activator activity|DNA-dependent ATPase activity|cell population proliferation|membrane|ubiquitin protein ligase binding|small-subunit processome|regulation of telomere maintenance|positive regulation of telomere maintenance via telomerase|positive regulation of type I interferon production|DNA duplex unwinding|protein-containing complex|protein-DNA complex|small-subunit processome assembly|U3 snoRNA binding|secretory granule lumen|telomeric DNA binding|response to drug|positive regulation of catalytic activity|neutrophil degranulation|Ku70:Ku80 complex|protein-containing complex binding|DNA end binding|innate immune response|positive regulation of protein kinase activity|negative regulation of transcription, DNA-templated|regulation of smooth muscle cell proliferation|positive regulation of neurogenesis|5'-deoxyribose-5-phosphate lyase activity|positive regulation of telomerase activity|hematopoietic stem cell differentiation|protein localization to chromosome, telomeric region|nonhomologous end joining complex|cellular response to fatty acid|cellular hyperosmotic salinity response|cellular response to gamma radiation|cellular response to X-ray|establishment of integrated proviral latency|site of DNA damage|negative regulation of t-circle formation|cellular response to leukemia inhibitory factor|ribonucleoprotein complex" hsa03450 Non-homologous end-joining XRCC6 9601.32711 8399.261275 10803.39295 1.286231323 0.363150129 0.147250583 1 211.2408751 267.1580214 2547 X-ray repair cross complementing 6 "GO:0000723,GO:0000781,GO:0000783,GO:0000976,GO:0002218,GO:0003677,GO:0003678,GO:0003684,GO:0003690,GO:0003691,GO:0003723,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005829,GO:0006266,GO:0006303,GO:0006310,GO:0007420,GO:0008022,GO:0008094,GO:0016020,GO:0030332,GO:0032481,GO:0032508,GO:0032991,GO:0032993,GO:0034774,GO:0042162,GO:0043312,GO:0043564,GO:0044877,GO:0045027,GO:0045087,GO:0045621,GO:0045860,GO:0045892,GO:0045893,GO:0045944,GO:0048660,GO:0051575,GO:0070419,GO:0071475,GO:0071480,GO:0071481,GO:0075713,GO:0097680,GO:1904813" "telomere maintenance|chromosome, telomeric region|nuclear telomere cap complex|transcription regulatory region sequence-specific DNA binding|activation of innate immune response|DNA binding|DNA helicase activity|damaged DNA binding|double-stranded DNA binding|double-stranded telomeric DNA binding|RNA binding|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytosol|DNA ligation|double-strand break repair via nonhomologous end joining|DNA recombination|brain development|protein C-terminus binding|DNA-dependent ATPase activity|membrane|cyclin binding|positive regulation of type I interferon production|DNA duplex unwinding|protein-containing complex|protein-DNA complex|secretory granule lumen|telomeric DNA binding|neutrophil degranulation|Ku70:Ku80 complex|protein-containing complex binding|DNA end binding|innate immune response|positive regulation of lymphocyte differentiation|positive regulation of protein kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|regulation of smooth muscle cell proliferation|5'-deoxyribose-5-phosphate lyase activity|nonhomologous end joining complex|cellular hyperosmotic salinity response|cellular response to gamma radiation|cellular response to X-ray|establishment of integrated proviral latency|double-strand break repair via classical nonhomologous end joining|ficolin-1-rich granule lumen" hsa03450 Non-homologous end-joining XRN1 1389.19768 1573.105791 1205.289569 0.766184688 -0.384235901 0.108791955 1 7.795149935 5.872582409 54464 5'-3' exoribonuclease 1 "GO:0000932,GO:0000956,GO:0002151,GO:0003723,GO:0004534,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0016020,GO:0016075,GO:0017148,GO:0030425,GO:0032211,GO:0033574,GO:0043025,GO:0043488,GO:0045202,GO:0051880,GO:0070034,GO:0071028,GO:0071044,GO:0071409,GO:0090503,GO:1905795" "P-body|nuclear-transcribed mRNA catabolic process|G-quadruplex RNA binding|RNA binding|5'-3' exoribonuclease activity|protein binding|nucleus|cytosol|plasma membrane|membrane|rRNA catabolic process|negative regulation of translation|dendrite|negative regulation of telomere maintenance via telomerase|response to testosterone|neuronal cell body|regulation of mRNA stability|synapse|G-quadruplex DNA binding|telomerase RNA binding|nuclear mRNA surveillance|histone mRNA catabolic process|cellular response to cycloheximide|RNA phosphodiester bond hydrolysis, exonucleolytic|cellular response to puromycin" "hsa03008,hsa03018" Ribosome biogenesis in eukaryotes|RNA degradation XRN2 4507.081694 4320.838855 4693.324533 1.086206797 0.119298796 0.61814091 1 52.97386361 56.5777072 22803 5'-3' exoribonuclease 2 "GO:0000175,GO:0000738,GO:0000956,GO:0001147,GO:0003723,GO:0004518,GO:0004534,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006353,GO:0006364,GO:0006396,GO:0006397,GO:0006401,GO:0007283,GO:0008409,GO:0016020,GO:0016070,GO:0016235,GO:0021766,GO:0030182,GO:0042802,GO:0046872,GO:0060041,GO:0090503" "3'-5'-exoribonuclease activity|DNA catabolic process, exonucleolytic|nuclear-transcribed mRNA catabolic process|transcription termination site sequence-specific DNA binding|RNA binding|nuclease activity|5'-3' exoribonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|DNA-templated transcription, termination|rRNA processing|RNA processing|mRNA processing|RNA catabolic process|spermatogenesis|5'-3' exonuclease activity|membrane|RNA metabolic process|aggresome|hippocampus development|neuron differentiation|identical protein binding|metal ion binding|retina development in camera-type eye|RNA phosphodiester bond hydrolysis, exonucleolytic" "hsa03008,hsa03018" Ribosome biogenesis in eukaryotes|RNA degradation other XRRA1 283.6580508 305.8816815 261.43442 0.854691326 -0.226524613 0.484969037 1 3.00466467 2.525087812 143570 X-ray radiation resistance associated 1 "GO:0003674,GO:0005634,GO:0005654,GO:0005737,GO:0010165,GO:0016604" molecular_function|nucleus|nucleoplasm|cytoplasm|response to X-ray|nuclear body XXYLT1 172.9621839 213.2848459 132.6395219 0.621889105 -0.685270753 0.074306265 1 0.94141264 0.57565748 152002 xyloside xylosyltransferase 1 "GO:0000287,GO:0016266,GO:0030145,GO:0030176,GO:0035252,GO:0140560" "magnesium ion binding|O-glycan processing|manganese ion binding|integral component of endoplasmic reticulum membrane|UDP-xylosyltransferase activity|xylosyl alpha-1,3-xylosyltransferase activity" hsa00514 Other types of O-glycan biosynthesis XYLB 138.7323214 185.1936711 92.27097178 0.498240416 -1.00508604 0.016288676 0.757645047 0.836587596 0.409846804 9942 xylulokinase "GO:0004856,GO:0005524,GO:0005829,GO:0005975,GO:0005997,GO:0005998,GO:0006091,GO:0016310,GO:0016773,GO:0019640,GO:0042732,GO:0046835" "xylulokinase activity|ATP binding|cytosol|carbohydrate metabolic process|xylulose metabolic process|xylulose catabolic process|generation of precursor metabolites and energy|phosphorylation|phosphotransferase activity, alcohol group as acceptor|glucuronate catabolic process to xylulose 5-phosphate|D-xylose metabolic process|carbohydrate phosphorylation" hsa00040 Pentose and glucuronate interconversions XYLT2 884.3177007 859.3818671 909.2535344 1.058032022 0.081383292 0.747081508 1 13.1001516 13.6284452 64132 xylosyltransferase 2 "GO:0000139,GO:0000287,GO:0005615,GO:0006024,GO:0015012,GO:0016021,GO:0018215,GO:0030145,GO:0030158,GO:0030203,GO:0030206,GO:0030210,GO:0050650" Golgi membrane|magnesium ion binding|extracellular space|glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process|integral component of membrane|protein phosphopantetheinylation|manganese ion binding|protein xylosyltransferase activity|glycosaminoglycan metabolic process|chondroitin sulfate biosynthetic process|heparin biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process "hsa00532,hsa00534" Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate|Glycosaminoglycan biosynthesis - heparan sulfate / heparin YAE1 163.851324 163.3449796 164.3576685 1.006199694 0.008916656 0.999854545 1 2.606884373 2.579153132 57002 YAE1 maturation factor of ABCE1 "GO:0005515,GO:0005634,GO:0005737,GO:0106035" protein binding|nucleus|cytoplasm|protein maturation by [4Fe-4S] cluster transfer YAF2 305.3928858 333.9728563 276.8129153 0.828848543 -0.270819596 0.389091509 1 1.894305189 1.543818731 10138 YY1 associated factor 2 "GO:0003677,GO:0003712,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0045892,GO:0045893,GO:0046872,GO:0070317" "DNA binding|transcription coregulator activity|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|negative regulation of G0 to G1 transition" YAP1 4236.973561 4080.503248 4393.443875 1.076691675 0.106605173 0.65544613 1 35.16940547 37.2329597 10413 Yes1 associated transcriptional regulator "GO:0000122,GO:0000902,GO:0000976,GO:0000978,GO:0001570,GO:0001674,GO:0001829,GO:0001894,GO:0003015,GO:0003143,GO:0003682,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006367,GO:0006974,GO:0008022,GO:0008283,GO:0010628,GO:0010629,GO:0010837,GO:0016020,GO:0030216,GO:0030857,GO:0030903,GO:0032570,GO:0033148,GO:0035019,GO:0035329,GO:0042060,GO:0045599,GO:0045669,GO:0045747,GO:0045893,GO:0045944,GO:0048339,GO:0048368,GO:0050679,GO:0050767,GO:0050847,GO:0060045,GO:0060242,GO:0060449,GO:0060487,GO:0060576,GO:0061026,GO:0065003,GO:0070064,GO:0070102,GO:0071300,GO:0071480,GO:0072091,GO:0072307,GO:0090263,GO:0140297,GO:0140552,GO:1900182,GO:1902018,GO:1902036,GO:1902459,GO:1904036,GO:2000737,GO:2001237" "negative regulation of transcription by RNA polymerase II|cell morphogenesis|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|vasculogenesis|female germ cell nucleus|trophectodermal cell differentiation|tissue homeostasis|heart process|embryonic heart tube morphogenesis|chromatin binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|transcription initiation from RNA polymerase II promoter|cellular response to DNA damage stimulus|protein C-terminus binding|cell population proliferation|positive regulation of gene expression|negative regulation of gene expression|regulation of keratinocyte proliferation|membrane|keratinocyte differentiation|negative regulation of epithelial cell differentiation|notochord development|response to progesterone|positive regulation of intracellular estrogen receptor signaling pathway|somatic stem cell population maintenance|hippo signaling|wound healing|negative regulation of fat cell differentiation|positive regulation of osteoblast differentiation|positive regulation of Notch signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|paraxial mesoderm development|lateral mesoderm development|positive regulation of epithelial cell proliferation|regulation of neurogenesis|progesterone receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|contact inhibition|bud elongation involved in lung branching|lung epithelial cell differentiation|intestinal epithelial cell development|cardiac muscle tissue regeneration|protein-containing complex assembly|proline-rich region binding|interleukin-6-mediated signaling pathway|cellular response to retinoic acid|cellular response to gamma radiation|regulation of stem cell proliferation|regulation of metanephric nephron tubule epithelial cell differentiation|positive regulation of canonical Wnt signaling pathway|DNA-binding transcription factor binding|TEAD-YAP complex|positive regulation of protein localization to nucleus|negative regulation of cilium assembly|regulation of hematopoietic stem cell differentiation|positive regulation of stem cell population maintenance|negative regulation of epithelial cell apoptotic process|negative regulation of stem cell differentiation|negative regulation of extrinsic apoptotic signaling pathway" "hsa04390,hsa04392" Hippo signaling pathway|Hippo signaling pathway - multiple species other YARS1 3022.146545 3300.192836 2744.100254 0.831496943 -0.266217135 0.260860526 1 70.70462712 57.80689887 8565 tyrosyl-tRNA synthetase 1 "GO:0000049,GO:0003723,GO:0004831,GO:0005153,GO:0005515,GO:0005524,GO:0005615,GO:0005737,GO:0005829,GO:0006418,GO:0006437,GO:0006915,GO:0016604" tRNA binding|RNA binding|tyrosine-tRNA ligase activity|interleukin-8 receptor binding|protein binding|ATP binding|extracellular space|cytoplasm|cytosol|tRNA aminoacylation for protein translation|tyrosyl-tRNA aminoacylation|apoptotic process|nuclear body hsa00970 Aminoacyl-tRNA biosynthesis YARS2 779.4283986 767.8254454 791.0313518 1.030222893 0.042956504 0.869803723 1 19.35636883 19.60768241 51067 tyrosyl-tRNA synthetase 2 "GO:0000049,GO:0003723,GO:0004831,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0005829,GO:0006412,GO:0006418,GO:0016604,GO:0042803,GO:0043039,GO:0070184,GO:0072545" tRNA binding|RNA binding|tyrosine-tRNA ligase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|cytosol|translation|tRNA aminoacylation for protein translation|nuclear body|protein homodimerization activity|tRNA aminoacylation|mitochondrial tyrosyl-tRNA aminoacylation|tyrosine binding hsa00970 Aminoacyl-tRNA biosynthesis YBEY 107.7677396 104.0413883 111.4940909 1.071632095 0.099809695 0.845733604 1 0.951911139 1.003028561 54059 ybeY metalloendoribonuclease "GO:0004222,GO:0004521,GO:0005634,GO:0006364,GO:0006508,GO:0046872,GO:0090502" "metalloendopeptidase activity|endoribonuclease activity|nucleus|rRNA processing|proteolysis|metal ion binding|RNA phosphodiester bond hydrolysis, endonucleolytic" YBX1 14858.45286 14255.75102 15461.15471 1.084555608 0.117104025 0.655272714 1 255.3887986 272.3484123 4904 Y-box binding protein 1 "GO:0000398,GO:0003676,GO:0003677,GO:0003690,GO:0003723,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005689,GO:0005737,GO:0005829,GO:0006355,GO:0007219,GO:0008544,GO:0010468,GO:0010494,GO:0017148,GO:0031965,GO:0035198,GO:0043231,GO:0045944,GO:0048255,GO:0048598,GO:0050658,GO:0051020,GO:0051031,GO:0051781,GO:0062153,GO:0070062,GO:0070934,GO:0070937,GO:0071204,GO:1903608,GO:1990124,GO:1990428,GO:1990837,GO:1990904,GO:2000773" "mRNA splicing, via spliceosome|nucleic acid binding|DNA binding|double-stranded DNA binding|RNA binding|protein binding|extracellular region|nucleus|nucleoplasm|U12-type spliceosomal complex|cytoplasm|cytosol|regulation of transcription, DNA-templated|Notch signaling pathway|epidermis development|regulation of gene expression|cytoplasmic stress granule|negative regulation of translation|nuclear membrane|miRNA binding|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|mRNA stabilization|embryonic morphogenesis|RNA transport|GTPase binding|tRNA transport|positive regulation of cell division|C5-methylcytidine-containing RNA binding|extracellular exosome|CRD-mediated mRNA stabilization|CRD-mediated mRNA stability complex|histone pre-mRNA 3'end processing complex|protein localization to cytoplasmic stress granule|messenger ribonucleoprotein complex|miRNA transport|sequence-specific double-stranded DNA binding|ribonucleoprotein complex|negative regulation of cellular senescence" YBX3 3370.299466 3066.099712 3674.49922 1.198427828 0.26114303 0.270949058 1 65.6366251 77.34447683 8531 Y-box binding protein 3 "GO:0000122,GO:0000977,GO:0001227,GO:0001701,GO:0003676,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005923,GO:0007283,GO:0008584,GO:0009566,GO:0010468,GO:0031267,GO:0046622,GO:0048471,GO:0048642,GO:0060546,GO:0070935,GO:0071356,GO:0071474,GO:1902219,GO:1905538,GO:2000767" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|in utero embryonic development|nucleic acid binding|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|cytosol|bicellular tight junction|spermatogenesis|male gonad development|fertilization|regulation of gene expression|small GTPase binding|positive regulation of organ growth|perinuclear region of cytoplasm|negative regulation of skeletal muscle tissue development|negative regulation of necroptotic process|3'-UTR-mediated mRNA stabilization|cellular response to tumor necrosis factor|cellular hyperosmotic response|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|polysome binding|positive regulation of cytoplasmic translation" hsa04530 Tight junction YDJC 371.0930603 380.791481 361.3946395 0.949061776 -0.075426097 0.806356457 1 15.52493619 14.48756792 150223 YdjC chitooligosaccharide deacetylase homolog "GO:0000287,GO:0005975,GO:0019213" magnesium ion binding|carbohydrate metabolic process|deacetylase activity YEATS2 3147.329563 3318.920286 2975.73884 0.896598467 -0.157466062 0.506565454 1 23.96491351 21.12735046 55689 YEATS domain containing 2 "GO:0000122,GO:0005515,GO:0005671,GO:0017025,GO:0042393,GO:0043966,GO:0045892,GO:0072686,GO:0140030" "negative regulation of transcription by RNA polymerase II|protein binding|Ada2/Gcn5/Ada3 transcription activator complex|TBP-class protein binding|histone binding|histone H3 acetylation|negative regulation of transcription, DNA-templated|mitotic spindle|modification-dependent protein binding" YEATS4 387.4723405 381.8318949 393.112786 1.02954413 0.04200567 0.894463186 1 13.88124418 14.05220701 8089 YEATS domain containing 4 "GO:0000278,GO:0005200,GO:0005515,GO:0005634,GO:0005654,GO:0007010,GO:0008022,GO:0016363,GO:0031965,GO:0035267,GO:0040008,GO:0043967,GO:0043968,GO:0045893,GO:0045944,GO:0070577,GO:0140030" "mitotic cell cycle|structural constituent of cytoskeleton|protein binding|nucleus|nucleoplasm|cytoskeleton organization|protein C-terminus binding|nuclear matrix|nuclear membrane|NuA4 histone acetyltransferase complex|regulation of growth|histone H4 acetylation|histone H2A acetylation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|lysine-acetylated histone binding|modification-dependent protein binding" YES1 2600.348034 2433.528072 2767.167997 1.137101326 0.185360817 0.433359767 1 25.70722893 28.74257079 7525 "YES proto-oncogene 1, Src family tyrosine kinase" "GO:0001784,GO:0004713,GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005794,GO:0005815,GO:0005829,GO:0005886,GO:0005925,GO:0006464,GO:0007169,GO:0019899,GO:0030154,GO:0031234,GO:0031295,GO:0038083,GO:0038096,GO:0042127,GO:0043114,GO:0044325,GO:0045087,GO:0048013,GO:0050900,GO:0070062" phosphotyrosine residue binding|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|protein binding|ATP binding|Golgi apparatus|microtubule organizing center|cytosol|plasma membrane|focal adhesion|cellular protein modification process|transmembrane receptor protein tyrosine kinase signaling pathway|enzyme binding|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|T cell costimulation|peptidyl-tyrosine autophosphorylation|Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of cell population proliferation|regulation of vascular permeability|ion channel binding|innate immune response|ephrin receptor signaling pathway|leukocyte migration|extracellular exosome hsa04520 Adherens junction YIF1A 1061.778694 1039.373469 1084.183918 1.043112943 0.060895375 0.806656537 1 50.56467798 51.86205946 10897 "Yip1 interacting factor homolog A, membrane trafficking protein" "GO:0005515,GO:0005789,GO:0005793,GO:0005794,GO:0006888,GO:0015031,GO:0030134,GO:0030173,GO:0033116,GO:0036498,GO:0043231" protein binding|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|endoplasmic reticulum to Golgi vesicle-mediated transport|protein transport|COPII-coated ER to Golgi transport vesicle|integral component of Golgi membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|IRE1-mediated unfolded protein response|intracellular membrane-bounded organelle YIF1B 709.2595978 679.3902654 739.1289302 1.087929822 0.121585497 0.63778035 1 10.97723578 11.74262124 90522 "Yip1 interacting factor homolog B, membrane trafficking protein" "GO:0005515,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0006612,GO:0006888,GO:0030134,GO:0030173,GO:0033116" protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|protein targeting to membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|COPII-coated ER to Golgi transport vesicle|integral component of Golgi membrane|endoplasmic reticulum-Golgi intermediate compartment membrane YIPF1 399.2490161 375.5894116 422.9086206 1.125986536 0.171189577 0.558373971 1 11.00742262 12.18680936 54432 Yip1 domain family member 1 "GO:0000138,GO:0005515,GO:0005654,GO:0005794,GO:0005797,GO:0005802,GO:0005886,GO:0016021,GO:0016192,GO:0030133,GO:0031902" Golgi trans cisterna|protein binding|nucleoplasm|Golgi apparatus|Golgi medial cisterna|trans-Golgi network|plasma membrane|integral component of membrane|vesicle-mediated transport|transport vesicle|late endosome membrane YIPF2 616.0136075 515.0048719 717.0223432 1.392263224 0.477431995 0.068107039 1 12.97067649 17.75640971 78992 Yip1 domain family member 2 "GO:0000138,GO:0005515,GO:0005794,GO:0005797,GO:0005802,GO:0016021,GO:0016192,GO:0030133,GO:0031902" Golgi trans cisterna|protein binding|Golgi apparatus|Golgi medial cisterna|trans-Golgi network|integral component of membrane|vesicle-mediated transport|transport vesicle|late endosome membrane YIPF3 976.8855825 917.6450445 1036.126121 1.129114277 0.175191507 0.478412033 1 32.49703349 36.07885906 25844 Yip1 domain family member 3 "GO:0005515,GO:0005794,GO:0005886,GO:0016021,GO:0030133,GO:0030154,GO:0043231" protein binding|Golgi apparatus|plasma membrane|integral component of membrane|transport vesicle|cell differentiation|intracellular membrane-bounded organelle YIPF4 636.4847318 598.2379825 674.7314811 1.127864664 0.173593965 0.507064964 1 13.18202379 14.6187507 84272 Yip1 domain family member 4 "GO:0005515,GO:0005783,GO:0005794,GO:0005886,GO:0016021,GO:0016032,GO:0043231" protein binding|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of membrane|viral process|intracellular membrane-bounded organelle YIPF5 2113.183431 1983.02886 2243.338001 1.131268458 0.177941332 0.452255453 1 31.17249061 34.67435249 81555 Yip1 domain family member 5 "GO:0005515,GO:0005654,GO:0005783,GO:0005789,GO:0005794,GO:0015031,GO:0016021,GO:0016192,GO:0030134,GO:0043231,GO:0060628,GO:0070971" protein binding|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein transport|integral component of membrane|vesicle-mediated transport|COPII-coated ER to Golgi transport vesicle|intracellular membrane-bounded organelle|regulation of ER to Golgi vesicle-mediated transport|endoplasmic reticulum exit site YIPF6 1859.577881 1835.290089 1883.865674 1.026467524 0.037687984 0.875772385 1 11.93154573 12.04240149 286451 Yip1 domain family member 6 "GO:0000138,GO:0000139,GO:0005515,GO:0005783,GO:0005797,GO:0005801,GO:0005802,GO:0016021,GO:0030134,GO:0042802,GO:0060576" Golgi trans cisterna|Golgi membrane|protein binding|endoplasmic reticulum|Golgi medial cisterna|cis-Golgi network|trans-Golgi network|integral component of membrane|COPII-coated ER to Golgi transport vesicle|identical protein binding|intestinal epithelial cell development YJEFN3 34.98784321 35.37407201 34.60161442 0.97816317 -0.03185295 1 1 0.7383063 0.710099259 374887 YjeF N-terminal domain containing 3 "GO:0002040,GO:0005515,GO:0005739,GO:0006869,GO:0008593,GO:0010874,GO:0016020,GO:0016525,GO:0031580,GO:0052856,GO:0052857,GO:0071425" sprouting angiogenesis|protein binding|mitochondrion|lipid transport|regulation of Notch signaling pathway|regulation of cholesterol efflux|membrane|negative regulation of angiogenesis|membrane raft distribution|NADHX epimerase activity|NADPHX epimerase activity|hematopoietic stem cell proliferation YJU2 189.7081857 198.7190516 180.6973197 0.909310498 -0.137155086 0.721983576 1 7.411090533 6.626214678 55702 YJU2 splicing factor homolog "GO:0000349,GO:0005515,GO:0008380,GO:0043518,GO:0046872,GO:0071006" "generation of catalytic spliceosome for first transesterification step|protein binding|RNA splicing|negative regulation of DNA damage response, signal transduction by p53 class mediator|metal ion binding|U2-type catalytic step 1 spliceosome" YKT6 2893.280491 2781.026308 3005.534674 1.080728602 0.112004272 0.636698303 1 52.66794278 55.96727721 10652 YKT6 v-SNARE homolog "GO:0000139,GO:0005484,GO:0005737,GO:0005739,GO:0005768,GO:0005783,GO:0005794,GO:0005829,GO:0005887,GO:0006888,GO:0006903,GO:0006904,GO:0015031,GO:0018215,GO:0019706,GO:0030133,GO:0030659,GO:0031201,GO:0033116,GO:0042147,GO:0043025,GO:0045296,GO:0061025,GO:0097440,GO:0097441" "Golgi membrane|SNAP receptor activity|cytoplasm|mitochondrion|endosome|endoplasmic reticulum|Golgi apparatus|cytosol|integral component of plasma membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|vesicle targeting|vesicle docking involved in exocytosis|protein transport|protein phosphopantetheinylation|protein-cysteine S-palmitoyltransferase activity|transport vesicle|cytoplasmic vesicle membrane|SNARE complex|endoplasmic reticulum-Golgi intermediate compartment membrane|retrograde transport, endosome to Golgi|neuronal cell body|cadherin binding|membrane fusion|apical dendrite|basal dendrite" hsa04130 SNARE interactions in vesicular transport YLPM1 1817.924884 2041.292038 1594.557731 0.781151203 -0.356326265 0.132764935 1 13.31296643 10.2254192 56252 YLP motif containing 1 "GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0008150,GO:0016607,GO:0032204" RNA binding|protein binding|nucleus|nucleoplasm|cytosol|biological_process|nuclear speck|regulation of telomere maintenance YME1L1 3112.020886 3085.867576 3138.174196 1.016950378 0.024249284 0.919827392 1 32.7474808 32.74528967 10730 YME1 like 1 ATPase "GO:0004176,GO:0004222,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0006508,GO:0006515,GO:0006851,GO:0007005,GO:0008283,GO:0016020,GO:0016021,GO:0016604,GO:0034214,GO:0034982,GO:0035694,GO:0043066,GO:0046872" ATP-dependent peptidase activity|metalloendopeptidase activity|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|proteolysis|protein quality control for misfolded or incompletely synthesized proteins|mitochondrial calcium ion transmembrane transport|mitochondrion organization|cell population proliferation|membrane|integral component of membrane|nuclear body|protein hexamerization|mitochondrial protein processing|mitochondrial protein catabolic process|negative regulation of apoptotic process|metal ion binding YOD1 879.1602907 837.5331755 920.7874058 1.099404099 0.136721763 0.585191746 1 6.584797622 7.118212717 55432 YOD1 deubiquitinase "GO:0004843,GO:0005515,GO:0005737,GO:0005829,GO:0008234,GO:0016236,GO:0016579,GO:0018215,GO:0030433,GO:0030968,GO:0031625,GO:0035523,GO:0035871,GO:0046872,GO:0061578,GO:0070536,GO:0071108,GO:0101005,GO:1904153,GO:1990167,GO:1990168,GO:1990380" "thiol-dependent ubiquitin-specific protease activity|protein binding|cytoplasm|cytosol|cysteine-type peptidase activity|macroautophagy|protein deubiquitination|protein phosphopantetheinylation|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|ubiquitin protein ligase binding|protein K29-linked deubiquitination|protein K11-linked deubiquitination|metal ion binding|Lys63-specific deubiquitinase activity|protein K63-linked deubiquitination|protein K48-linked deubiquitination|ubiquitinyl hydrolase activity|negative regulation of retrograde protein transport, ER to cytosol|protein K27-linked deubiquitination|protein K33-linked deubiquitination|Lys48-specific deubiquitinase activity" hsa04141 Protein processing in endoplasmic reticulum YPEL1 203.8034629 202.8807071 204.7262186 1.009096535 0.013064197 0.986605936 1 2.519751096 2.500123927 29799 yippee like 1 "GO:0005634,GO:0046872" nucleus|metal ion binding YPEL2 150.3655725 137.3346325 163.3965125 1.189769176 0.250681707 0.543956434 1 1.352767982 1.582549151 388403 yippee like 2 "GO:0005515,GO:0005730,GO:0046872" protein binding|nucleolus|metal ion binding YPEL3 488.7151636 478.590386 498.8399412 1.042310827 0.059785568 0.834617621 1 15.95345989 16.35020915 83719 yippee like 3 "GO:0005730,GO:0046872,GO:2000774" nucleolus|metal ion binding|positive regulation of cellular senescence YPEL4 46.04113671 35.37407201 56.7082014 1.603100751 0.680865098 0.275210617 1 1.003107975 1.581174054 219539 yippee like 4 "GO:0005730,GO:0046872" nucleolus|metal ion binding YPEL5 1593.959111 1485.711024 1702.207198 1.145718898 0.196253123 0.410187922 1 22.59608628 25.45554969 51646 yippee like 5 "GO:0000151,GO:0005515,GO:0005576,GO:0005634,GO:0005813,GO:0008283,GO:0030496,GO:0043312,GO:0046872,GO:0097431,GO:1904724,GO:1904813" ubiquitin ligase complex|protein binding|extracellular region|nucleus|centrosome|cell population proliferation|midbody|neutrophil degranulation|metal ion binding|mitotic spindle pole|tertiary granule lumen|ficolin-1-rich granule lumen YRDC 276.0977508 284.03299 268.1625117 0.944124525 -0.082950939 0.80780634 1 8.202553379 7.614642581 79693 yrdC N6-threonylcarbamoyltransferase domain containing "GO:0000049,GO:0003725,GO:0005515,GO:0005737,GO:0005739,GO:0006450,GO:0016020,GO:0016779,GO:0051051" tRNA binding|double-stranded RNA binding|protein binding|cytoplasm|mitochondrion|regulation of translational fidelity|membrane|nucleotidyltransferase activity|negative regulation of transport YTHDC1 1393.216525 1438.8924 1347.54065 0.936512453 -0.094629917 0.694804551 1 12.10642327 11.14809315 91746 YTH domain containing 1 "GO:0000381,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0006376,GO:0006406,GO:0009048,GO:0010608,GO:0016607,GO:0048024,GO:1990247" "regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|plasma membrane|mRNA splice site selection|mRNA export from nucleus|dosage compensation by inactivation of X chromosome|posttranscriptional regulation of gene expression|nuclear speck|regulation of mRNA splicing, via spliceosome|N6-methyladenosine-containing RNA binding" YTHDC2 866.9571429 908.2813195 825.6329662 0.909005777 -0.137638632 0.583167569 1 6.164734157 5.510007307 64848 YTH domain containing 2 "GO:0003723,GO:0005515,GO:0005524,GO:0005622,GO:0005634,GO:0005783,GO:0007286,GO:0008186,GO:0034458,GO:0034612,GO:0035770,GO:0044829,GO:0048599,GO:0051321,GO:0051729,GO:0070063,GO:0070555,GO:1990247" "RNA binding|protein binding|ATP binding|intracellular anatomical structure|nucleus|endoplasmic reticulum|spermatid development|RNA-dependent ATPase activity|3'-5' RNA helicase activity|response to tumor necrosis factor|ribonucleoprotein granule|positive regulation by host of viral genome replication|oocyte development|meiotic cell cycle|germline cell cycle switching, mitotic to meiotic cell cycle|RNA polymerase binding|response to interleukin-1|N6-methyladenosine-containing RNA binding" YTHDF1 1485.932862 1526.287166 1445.578558 0.947120955 -0.078379414 0.744752548 1 24.63112817 22.93828413 54915 YTH N6-methyladenosine RNA binding protein 1 "GO:0002376,GO:0002577,GO:0003723,GO:0003729,GO:0005515,GO:0005737,GO:0007612,GO:0007613,GO:0043022,GO:0045727,GO:0045948,GO:0061157,GO:1900271,GO:1902667,GO:1990247" immune system process|regulation of antigen processing and presentation|RNA binding|mRNA binding|protein binding|cytoplasm|learning|memory|ribosome binding|positive regulation of translation|positive regulation of translational initiation|mRNA destabilization|regulation of long-term synaptic potentiation|regulation of axon guidance|N6-methyladenosine-containing RNA binding YTHDF2 1183.195731 1161.101893 1205.289569 1.038056674 0.053885211 0.827176537 1 21.14876246 21.58625001 51441 YTH N6-methyladenosine RNA binding protein 2 "GO:0000932,GO:0001556,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006402,GO:0006959,GO:0016032,GO:0034451,GO:0036464,GO:0043488,GO:0045087,GO:0045746,GO:0045948,GO:0048598,GO:0050767,GO:0060339,GO:0061157,GO:0071425,GO:0098508,GO:1902036,GO:1903538,GO:1903679,GO:1990247" P-body|oocyte maturation|RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|cytosol|mRNA catabolic process|humoral immune response|viral process|centriolar satellite|cytoplasmic ribonucleoprotein granule|regulation of mRNA stability|innate immune response|negative regulation of Notch signaling pathway|positive regulation of translational initiation|embryonic morphogenesis|regulation of neurogenesis|negative regulation of type I interferon-mediated signaling pathway|mRNA destabilization|hematopoietic stem cell proliferation|endothelial to hematopoietic transition|regulation of hematopoietic stem cell differentiation|regulation of meiotic cell cycle process involved in oocyte maturation|positive regulation of cap-independent translational initiation|N6-methyladenosine-containing RNA binding YTHDF3 3062.139542 3138.928684 2985.350399 0.951073025 -0.072371977 0.760851176 1 31.64913183 29.59694218 253943 YTH N6-methyladenosine RNA binding protein 3 "GO:0003723,GO:0003729,GO:0005515,GO:0005737,GO:0005829,GO:0043022,GO:0045727,GO:0045948,GO:0060339,GO:0061157,GO:1990247" RNA binding|mRNA binding|protein binding|cytoplasm|cytosol|ribosome binding|positive regulation of translation|positive regulation of translational initiation|negative regulation of type I interferon-mediated signaling pathway|mRNA destabilization|N6-methyladenosine-containing RNA binding YWHAB 10289.05125 8853.922141 11724.18035 1.324179292 0.405098474 0.108252342 1 142.5822426 185.6450662 7529 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta "GO:0000165,GO:0004860,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005774,GO:0005829,GO:0005925,GO:0006469,GO:0006605,GO:0008022,GO:0016020,GO:0016032,GO:0017053,GO:0019899,GO:0019904,GO:0035308,GO:0035329,GO:0042470,GO:0042802,GO:0042826,GO:0043085,GO:0043488,GO:0044877,GO:0045296,GO:0045744,GO:0045892,GO:0048471,GO:0050815,GO:0051219,GO:0051220,GO:0061024,GO:0070062,GO:1900740" "MAPK cascade|protein kinase inhibitor activity|protein binding|nucleus|cytoplasm|mitochondrion|vacuolar membrane|cytosol|focal adhesion|negative regulation of protein kinase activity|protein targeting|protein C-terminus binding|membrane|viral process|transcription repressor complex|enzyme binding|protein domain specific binding|negative regulation of protein dephosphorylation|hippo signaling|melanosome|identical protein binding|histone deacetylase binding|positive regulation of catalytic activity|regulation of mRNA stability|protein-containing complex binding|cadherin binding|negative regulation of G protein-coupled receptor signaling pathway|negative regulation of transcription, DNA-templated|perinuclear region of cytoplasm|phosphoserine residue binding|phosphoprotein binding|cytoplasmic sequestering of protein|membrane organization|extracellular exosome|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" "hsa04110,hsa04114,hsa04151,hsa04390,hsa05160,hsa05161,hsa05203" Cell cycle|Oocyte meiosis|PI3K-Akt signaling pathway|Hippo signaling pathway|Hepatitis C|Hepatitis B|Viral carcinogenesis YWHAE 12201.19334 11034.62964 13367.75704 1.211436856 0.276719209 0.280476651 1 276.4778888 329.3308122 7531 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon "GO:0000086,GO:0000165,GO:0003064,GO:0003723,GO:0005246,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005871,GO:0005886,GO:0005925,GO:0010389,GO:0015459,GO:0016020,GO:0016032,GO:0019899,GO:0021762,GO:0023026,GO:0031625,GO:0034504,GO:0034605,GO:0035329,GO:0035556,GO:0042470,GO:0042802,GO:0042826,GO:0043154,GO:0044325,GO:0045296,GO:0046827,GO:0046982,GO:0050815,GO:0051219,GO:0051480,GO:0060306,GO:0061024,GO:0070062,GO:0086013,GO:0086091,GO:0090724,GO:0097110,GO:0097711,GO:0098978,GO:0099072,GO:1900034,GO:1900740,GO:1901016,GO:1901020,GO:1902309,GO:1905913" G2/M transition of mitotic cell cycle|MAPK cascade|regulation of heart rate by hormone|RNA binding|calcium channel regulator activity|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|kinesin complex|plasma membrane|focal adhesion|regulation of G2/M transition of mitotic cell cycle|potassium channel regulator activity|membrane|viral process|enzyme binding|substantia nigra development|MHC class II protein complex binding|ubiquitin protein ligase binding|protein localization to nucleus|cellular response to heat|hippo signaling|intracellular signal transduction|melanosome|identical protein binding|histone deacetylase binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|ion channel binding|cadherin binding|positive regulation of protein export from nucleus|protein heterodimerization activity|phosphoserine residue binding|phosphoprotein binding|regulation of cytosolic calcium ion concentration|regulation of membrane repolarization|membrane organization|extracellular exosome|membrane repolarization during cardiac muscle cell action potential|regulation of heart rate by cardiac conduction|central region of growth cone|scaffold protein binding|ciliary basal body-plasma membrane docking|glutamatergic synapse|regulation of postsynaptic membrane neurotransmitter receptor levels|regulation of cellular response to heat|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|regulation of potassium ion transmembrane transporter activity|negative regulation of calcium ion transmembrane transporter activity|negative regulation of peptidyl-serine dephosphorylation|negative regulation of calcium ion export across plasma membrane "hsa04110,hsa04114,hsa04151,hsa04390,hsa04621,hsa04722,hsa05160,hsa05203" Cell cycle|Oocyte meiosis|PI3K-Akt signaling pathway|Hippo signaling pathway|NOD-like receptor signaling pathway|Neurotrophin signaling pathway|Hepatitis C|Viral carcinogenesis YWHAG 5947.169721 6119.714458 5774.624984 0.9436102 -0.083737081 0.729768942 1 88.15058382 81.78788889 7532 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma "GO:0000086,GO:0003723,GO:0005080,GO:0005159,GO:0005515,GO:0005739,GO:0005829,GO:0005925,GO:0006469,GO:0006605,GO:0008426,GO:0009966,GO:0010389,GO:0016020,GO:0019904,GO:0030971,GO:0032869,GO:0042802,GO:0045664,GO:0048167,GO:0061024,GO:0070062,GO:0071901,GO:0097711,GO:0098793,GO:1900740" G2/M transition of mitotic cell cycle|RNA binding|protein kinase C binding|insulin-like growth factor receptor binding|protein binding|mitochondrion|cytosol|focal adhesion|negative regulation of protein kinase activity|protein targeting|protein kinase C inhibitor activity|regulation of signal transduction|regulation of G2/M transition of mitotic cell cycle|membrane|protein domain specific binding|receptor tyrosine kinase binding|cellular response to insulin stimulus|identical protein binding|regulation of neuron differentiation|regulation of synaptic plasticity|membrane organization|extracellular exosome|negative regulation of protein serine/threonine kinase activity|ciliary basal body-plasma membrane docking|presynapse|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway "hsa04110,hsa04114,hsa04151,hsa04390,hsa05160,hsa05203" Cell cycle|Oocyte meiosis|PI3K-Akt signaling pathway|Hippo signaling pathway|Hepatitis C|Viral carcinogenesis YWHAH 3510.557195 3341.809391 3679.305 1.100991879 0.138803827 0.559112012 1 101.8539265 110.263829 7533 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta "GO:0002028,GO:0003779,GO:0005159,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006713,GO:0006886,GO:0014704,GO:0017080,GO:0019899,GO:0019904,GO:0021762,GO:0035259,GO:0042802,GO:0042921,GO:0044325,GO:0045664,GO:0045893,GO:0046982,GO:0048167,GO:0050774,GO:0061024,GO:0070062,GO:0086010,GO:1900740,GO:2000649" "regulation of sodium ion transport|actin binding|insulin-like growth factor receptor binding|protein binding|cytoplasm|mitochondrion|cytosol|plasma membrane|glucocorticoid catabolic process|intracellular protein transport|intercalated disc|sodium channel regulator activity|enzyme binding|protein domain specific binding|substantia nigra development|glucocorticoid receptor binding|identical protein binding|glucocorticoid receptor signaling pathway|ion channel binding|regulation of neuron differentiation|positive regulation of transcription, DNA-templated|protein heterodimerization activity|regulation of synaptic plasticity|negative regulation of dendrite morphogenesis|membrane organization|extracellular exosome|membrane depolarization during action potential|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|regulation of sodium ion transmembrane transporter activity" "hsa04110,hsa04114,hsa04151,hsa04390,hsa05160,hsa05203" Cell cycle|Oocyte meiosis|PI3K-Akt signaling pathway|Hippo signaling pathway|Hepatitis C|Viral carcinogenesis YWHAQ 9175.024261 8474.171074 9875.877448 1.165409261 0.22083668 0.375979098 1 205.9430489 235.9917286 10971 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta "GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0005925,GO:0006605,GO:0007264,GO:0008022,GO:0016020,GO:0019904,GO:0021762,GO:0032991,GO:0034766,GO:0042802,GO:0044325,GO:0045202,GO:0045892,GO:0047485,GO:0061024,GO:0070062,GO:0071889,GO:1900740" "protein binding|cytoplasm|mitochondrion|cytosol|focal adhesion|protein targeting|small GTPase mediated signal transduction|protein C-terminus binding|membrane|protein domain specific binding|substantia nigra development|protein-containing complex|negative regulation of ion transmembrane transport|identical protein binding|ion channel binding|synapse|negative regulation of transcription, DNA-templated|protein N-terminus binding|membrane organization|extracellular exosome|14-3-3 protein binding|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" "hsa04110,hsa04114,hsa04151,hsa04390,hsa05160,hsa05161,hsa05203" Cell cycle|Oocyte meiosis|PI3K-Akt signaling pathway|Hippo signaling pathway|Hepatitis C|Hepatitis B|Viral carcinogenesis YWHAZ 29216.85522 26347.44116 32086.26928 1.21781349 0.284293199 0.331034657 1 207.3915207 248.3378719 7534 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta "GO:0003723,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005925,GO:0006468,GO:0007165,GO:0008134,GO:0019221,GO:0019901,GO:0030168,GO:0031625,GO:0031982,GO:0042470,GO:0042802,GO:0043066,GO:0043488,GO:0044325,GO:0045296,GO:0051683,GO:0061024,GO:0070062,GO:0070372,GO:0072562,GO:0090128,GO:0090168,GO:0098978,GO:1900740" RNA binding|protein binding|extracellular space|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|focal adhesion|protein phosphorylation|signal transduction|transcription factor binding|cytokine-mediated signaling pathway|protein kinase binding|platelet activation|ubiquitin protein ligase binding|vesicle|melanosome|identical protein binding|negative regulation of apoptotic process|regulation of mRNA stability|ion channel binding|cadherin binding|establishment of Golgi localization|membrane organization|extracellular exosome|regulation of ERK1 and ERK2 cascade|blood microparticle|regulation of synapse maturation|Golgi reassembly|glutamatergic synapse|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway "hsa04110,hsa04114,hsa04151,hsa04390,hsa05160,hsa05161,hsa05203" Cell cycle|Oocyte meiosis|PI3K-Akt signaling pathway|Hippo signaling pathway|Hepatitis C|Hepatitis B|Viral carcinogenesis YY1 3319.089015 3336.607322 3301.570709 0.98949933 -0.015229365 0.950130561 1 27.25261713 26.51519943 7528 YY1 transcription factor "GO:0000122,GO:0000400,GO:0000724,GO:0000976,GO:0000978,GO:0000981,GO:0000987,GO:0001217,GO:0001227,GO:0003677,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005677,GO:0005737,GO:0006357,GO:0006403,GO:0006974,GO:0007283,GO:0009952,GO:0010225,GO:0010629,GO:0016363,GO:0016579,GO:0030183,GO:0031011,GO:0031519,GO:0032688,GO:0034644,GO:0034696,GO:0045944,GO:0046332,GO:0046872,GO:0048468,GO:0048593,GO:0051276,GO:0061052,GO:0071347,GO:0071707,GO:1902894,GO:1990837" "negative regulation of transcription by RNA polymerase II|four-way junction DNA binding|double-strand break repair via homologous recombination|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|chromatin silencing complex|cytoplasm|regulation of transcription by RNA polymerase II|RNA localization|cellular response to DNA damage stimulus|spermatogenesis|anterior/posterior pattern specification|response to UV-C|negative regulation of gene expression|nuclear matrix|protein deubiquitination|B cell differentiation|Ino80 complex|PcG protein complex|negative regulation of interferon-beta production|cellular response to UV|response to prostaglandin F|positive regulation of transcription by RNA polymerase II|SMAD binding|metal ion binding|cell development|camera-type eye morphogenesis|chromosome organization|negative regulation of cell growth involved in cardiac muscle cell development|cellular response to interleukin-1|immunoglobulin heavy chain V-D-J recombination|negative regulation of pri-miRNA transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" chromosome_remodelling_factor YY1AP1 1322.051355 1437.851986 1206.250725 0.83892552 -0.253385361 0.292035997 1 22.86517218 18.86118871 55249 YY1 associated protein 1 "GO:0001650,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006355,GO:0008283,GO:0030154,GO:0031011,GO:0051726" "fibrillar center|transcription coregulator activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|regulation of transcription, DNA-templated|cell population proliferation|cell differentiation|Ino80 complex|regulation of cell cycle" YY2 129.5076051 119.6475965 139.3676136 1.164817495 0.220103929 0.617270396 1 2.31858109 2.655530861 404281 YY2 transcription factor "GO:0000978,GO:0000981,GO:0000987,GO:0001228,GO:0005634,GO:0005667,GO:0006357,GO:0031519,GO:0043565,GO:0045944,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|PcG protein complex|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZACN 3.601819626 6.242483296 0.961155956 0.153970129 -2.699277611 0.237188726 1 0.225864312 0.034194422 353174 zinc activated ion channel "GO:0004888,GO:0005230,GO:0005886,GO:0005887,GO:0007165,GO:0007268,GO:0008270,GO:0010043,GO:0015276,GO:0030594,GO:0034220,GO:0042391,GO:0043005,GO:0045202,GO:0050877" transmembrane signaling receptor activity|extracellular ligand-gated ion channel activity|plasma membrane|integral component of plasma membrane|signal transduction|chemical synaptic transmission|zinc ion binding|response to zinc ion|ligand-gated ion channel activity|neurotransmitter receptor activity|ion transmembrane transport|regulation of membrane potential|neuron projection|synapse|nervous system process ZADH2 840.9663031 907.2409057 774.6917005 0.853898557 -0.227863406 0.363134368 1 5.603261162 4.704552543 284273 zinc binding alcohol dehydrogenase domain containing 2 "GO:0003674,GO:0005777,GO:0006693,GO:0008150,GO:0008270,GO:0036132,GO:0045599,GO:0047522,GO:0055114" molecular_function|peroxisome|prostaglandin metabolic process|biological_process|zinc ion binding|13-prostaglandin reductase activity|negative regulation of fat cell differentiation|15-oxoprostaglandin 13-oxidase activity|oxidation-reduction process ZAR1 6.083967443 8.323311061 3.844623824 0.461910386 -1.11431511 0.492415049 1 0.304246448 0.138182938 326340 zygote arrest 1 "GO:0005515,GO:0005737,GO:0006412,GO:0007275,GO:0016441,GO:1903231" protein binding|cytoplasm|translation|multicellular organism development|posttranscriptional gene silencing|mRNA binding involved in posttranscriptional gene silencing ZBBX 17.33540575 13.52538047 21.14543103 1.563388998 0.644676791 0.500912802 1 0.148279519 0.227939399 79740 zinc finger B-box domain containing "GO:0003341,GO:0031514,GO:0046872" cilium movement|motile cilium|metal ion binding ZBED1-2 17.93487062 16.64662212 19.22311912 1.154775965 0.207612985 0.876458915 1 0.184583343 0.209585591 9189 zinc finger BED-type containing 1 ZBED2 1.961940875 1.040413883 2.883467868 2.771462315 1.470647391 0.772840642 1 0.025079032 0.06834251 79413 zinc finger BED-type containing 2 "GO:0000122,GO:0000785,GO:0000976,GO:0000981,GO:0005634,GO:0045618,GO:0046872" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|positive regulation of keratinocyte differentiation|metal ion binding" ZBED3 234.3321261 272.5884373 196.075815 0.71931083 -0.475312769 0.16540751 1 2.371624372 1.677388582 84327 zinc finger BED-type containing 3 "GO:0000785,GO:0000981,GO:0001933,GO:0003677,GO:0005615,GO:0005737,GO:0005829,GO:0007015,GO:0009749,GO:0016020,GO:0016055,GO:0032868,GO:0040019,GO:0045944,GO:0046872,GO:0050821,GO:0051293,GO:0051643,GO:0051646,GO:0090263" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|negative regulation of protein phosphorylation|DNA binding|extracellular space|cytoplasm|cytosol|actin filament organization|response to glucose|membrane|Wnt signaling pathway|response to insulin|positive regulation of embryonic development|positive regulation of transcription by RNA polymerase II|metal ion binding|protein stabilization|establishment of spindle localization|endoplasmic reticulum localization|mitochondrion localization|positive regulation of canonical Wnt signaling pathway" ZBED4 989.8354215 1080.990024 898.6808189 0.83134978 -0.266472494 0.279062675 1 7.084667912 5.791278664 9889 zinc finger BED-type containing 4 "GO:0000785,GO:0000976,GO:0000981,GO:0001917,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0042802,GO:0045944,GO:0046872,GO:0046983" "chromatin|transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|photoreceptor inner segment|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|identical protein binding|positive regulation of transcription by RNA polymerase II|metal ion binding|protein dimerization activity" zf-BED ZBED5 624.3809636 621.1270879 627.6348393 1.010477327 0.01503695 0.960832045 1 12.19139798 12.11298726 58486 zinc finger BED-type containing 5 "GO:0000785,GO:0000981,GO:0003677,GO:0006357,GO:0046872" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|regulation of transcription by RNA polymerase II|metal ion binding" ZBED6 832.7914471 919.7258723 745.8570219 0.810955791 -0.302304827 0.22748913 1 13.81871605 11.01884441 100381270 zinc finger BED-type containing 6 "GO:0000122,GO:0000785,GO:0000976,GO:0000981,GO:0001835,GO:0003309,GO:0005634,GO:0005730,GO:0005737,GO:0006357,GO:0045787,GO:0045892,GO:0046872,GO:0046983,GO:0051148,GO:0060548,GO:0061178" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|blastocyst hatching|type B pancreatic cell differentiation|nucleus|nucleolus|cytoplasm|regulation of transcription by RNA polymerase II|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|metal ion binding|protein dimerization activity|negative regulation of muscle cell differentiation|negative regulation of cell death|regulation of insulin secretion involved in cellular response to glucose stimulus" ZBED6CL 162.1422482 131.0921492 193.1923472 1.473714088 0.559456658 0.156078461 1 2.435136466 3.528642967 113763 ZBED6 C-terminal like ZBED8 320.2216061 306.9220954 333.5211167 1.086663755 0.119905598 0.704760568 1 5.683507332 6.072713397 63920 zinc finger BED-type containing 8 "GO:0005515,GO:0005654" protein binding|nucleoplasm ZBED9 44.43082608 56.18234966 32.6793025 0.58166493 -0.781739771 0.213442178 1 0.339833248 0.194361358 114821 zinc finger BED-type containing 9 "GO:0003676,GO:0005634,GO:0005737,GO:0015074,GO:0045787,GO:0050679" nucleic acid binding|nucleus|cytoplasm|DNA integration|positive regulation of cell cycle|positive regulation of epithelial cell proliferation ZBTB1 708.83374 642.9757795 774.6917005 1.204853628 0.268857891 0.293790622 1 5.909150269 7.000523252 22890 zinc finger and BTB domain containing 1 "GO:0000122,GO:0000978,GO:0001227,GO:0002711,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0006281,GO:0006338,GO:0006357,GO:0006974,GO:0016604,GO:0019985,GO:0030183,GO:0031965,GO:0032825,GO:0033077,GO:0034644,GO:0042789,GO:0042803,GO:0045087,GO:0045582,GO:0046872,GO:0046982,GO:0048538,GO:0051260,GO:0070530,GO:2000176" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|positive regulation of T cell mediated immunity|protein binding|nucleus|nucleoplasm|centrosome|DNA repair|chromatin remodeling|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|nuclear body|translesion synthesis|B cell differentiation|nuclear membrane|positive regulation of natural killer cell differentiation|T cell differentiation in thymus|cellular response to UV|mRNA transcription by RNA polymerase II|protein homodimerization activity|innate immune response|positive regulation of T cell differentiation|metal ion binding|protein heterodimerization activity|thymus development|protein homooligomerization|K63-linked polyubiquitin modification-dependent protein binding|positive regulation of pro-T cell differentiation" ZBTB10 755.3944693 780.310412 730.4785266 0.936138382 -0.095206287 0.710900907 1 4.101618491 3.775430611 65986 zinc finger and BTB domain containing 10 "GO:0000977,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0046872" RNA polymerase II transcription regulatory region sequence-specific DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding ZBTB ZBTB11 1005.749215 1044.575538 966.9228917 0.925661052 -0.111444074 0.65254104 1 6.718134083 6.114653289 27107 zinc finger and BTB domain containing 11 "GO:0000978,GO:0000981,GO:0003674,GO:0005654,GO:0005730,GO:0006355,GO:0006357,GO:0008150,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|nucleoplasm|nucleolus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" ZBTB12 77.70456304 71.7885579 83.62056817 1.164817495 0.220103929 0.684108942 1 1.562489149 1.789559215 221527 zinc finger and BTB domain containing 12 "GO:0000122,GO:0000978,GO:0001227,GO:0005515,GO:0005654,GO:0006357,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZBTB ZBTB14 621.2005857 562.8639105 679.5372609 1.207285186 0.271766511 0.299094625 1 6.464173102 7.673509374 7541 zinc finger and BTB domain containing 14 "GO:0000122,GO:0000976,GO:0000978,GO:0001227,GO:0001822,GO:0003170,GO:0003279,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0016235,GO:0043565,GO:0045892,GO:0046872,GO:0060976,GO:1990837" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|kidney development|heart valve development|cardiac septum development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|aggresome|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding|coronary vasculature development|sequence-specific double-stranded DNA binding" other ZBTB17 401.5575568 410.9634836 392.15163 0.954225 -0.067598611 0.822719355 1 4.712583971 4.421616485 7709 zinc finger and BTB domain containing 17 "GO:0000122,GO:0000978,GO:0001046,GO:0001223,GO:0001227,GO:0001228,GO:0001702,GO:0003700,GO:0005515,GO:0005654,GO:0006357,GO:0007398,GO:0008134,GO:0008285,GO:0032991,GO:0032993,GO:0036498,GO:0045786,GO:0045944,GO:0046872,GO:0071158" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|core promoter sequence-specific DNA binding|transcription coactivator binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|gastrulation with mouth forming second|DNA-binding transcription factor activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|ectoderm development|transcription factor binding|negative regulation of cell population proliferation|protein-containing complex|protein-DNA complex|IRE1-mediated unfolded protein response|negative regulation of cell cycle|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of cell cycle arrest" "hsa04110,hsa05200,hsa05202,hsa05222" Cell cycle|Pathways in cancer|Transcriptional misregulation in cancer|Small cell lung cancer ZBTB ZBTB18 413.9632655 433.8525891 394.073942 0.908312989 -0.138738584 0.633250791 1 3.390527938 3.028126617 10472 zinc finger and BTB domain containing 18 "GO:0000122,GO:0000792,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007519,GO:0016607,GO:0043565,GO:0045892,GO:0045944,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|heterochromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|skeletal muscle tissue development|nuclear speck|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" other ZBTB2 384.821616 400.5593448 369.0838871 0.921421237 -0.118067245 0.692408363 1 5.572762262 5.048936545 57621 zinc finger and BTB domain containing 2 "GO:0000122,GO:0000978,GO:0001227,GO:0005515,GO:0005654,GO:0006357,GO:0042802,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|identical protein binding|metal ion binding|sequence-specific double-stranded DNA binding" ZBTB ZBTB20 439.9685822 498.3582498 381.5789145 0.765671913 -0.385201759 0.171873541 1 0.927902308 0.698580003 26137 zinc finger and BTB domain containing 20 "GO:0000122,GO:0000976,GO:0000978,GO:0001227,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0016604,GO:0045821,GO:0046872,GO:0046889,GO:0055088,GO:0071333,GO:1990837" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|nuclear body|positive regulation of glycolytic process|metal ion binding|positive regulation of lipid biosynthetic process|lipid homeostasis|cellular response to glucose stimulus|sequence-specific double-stranded DNA binding" ZBTB21 711.7807602 783.4316536 640.1298667 0.817084507 -0.291442798 0.254418633 1 5.082702099 4.083502357 49854 zinc finger and BTB domain containing 21 "GO:0000122,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0008327,GO:0031208,GO:0043565,GO:0045892,GO:0046872" "negative regulation of transcription by RNA polymerase II|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|methyl-CpG binding|POZ domain binding|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding" ZBTB22 237.4785199 216.4060876 258.5509522 1.194748979 0.256707535 0.455942292 1 4.238236755 4.978896061 9278 zinc finger and BTB domain containing 22 "GO:0000785,GO:0000977,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZBTB24 199.4285713 226.8102264 172.0469161 0.758550083 -0.398683657 0.27437481 1 2.151136471 1.604439711 9841 zinc finger and BTB domain containing 24 "GO:0000978,GO:0002244,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|hematopoietic progenitor cell differentiation|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding ZBTB25 480.8523088 511.8836303 449.8209874 0.878756344 -0.186464896 0.501923731 1 2.039896098 1.762575378 7597 zinc finger and BTB domain containing 25 "GO:0000122,GO:0000978,GO:0001227,GO:0003700,GO:0005515,GO:0005654,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding" ZBTB26 508.2798521 525.4090107 491.1506935 0.93479686 -0.097275207 0.726250185 1 6.021067907 5.534290461 57684 zinc finger and BTB domain containing 26 "GO:0000122,GO:0000978,GO:0001227,GO:0005515,GO:0005575,GO:0005654,GO:0006357,GO:0008150,GO:0042802,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|cellular_component|nucleoplasm|regulation of transcription by RNA polymerase II|biological_process|identical protein binding|metal ion binding|sequence-specific double-stranded DNA binding" ZBTB ZBTB3 58.5261033 60.34400519 56.7082014 0.939748716 -0.089653056 0.904678206 1 1.091677508 1.008735447 79842 zinc finger and BTB domain containing 3 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZBTB33 1748.783249 1689.632145 1807.934353 1.070016547 0.097633106 0.682219299 1 17.16591704 18.06045475 10009 zinc finger and BTB domain containing 33 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0006357,GO:0008327,GO:0016055,GO:0035556,GO:0043565,GO:0045892,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|methyl-CpG binding|Wnt signaling pathway|intracellular signal transduction|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding|sequence-specific double-stranded DNA binding" other ZBTB34 341.1984604 327.730373 354.6665478 1.082190047 0.113953878 0.71362781 1 2.571734696 2.736534186 403341 zinc finger and BTB domain containing 34 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005654,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding" ZBTB37 272.8922208 288.1946455 257.5897962 0.893804934 -0.161968086 0.625207909 1 0.784715232 0.689645663 84614 zinc finger and BTB domain containing 37 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005654,GO:0006357,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZBTB38 2577.460887 2879.865627 2275.056148 0.78998691 -0.340099347 0.150311932 1 13.05360417 10.13961612 253461 zinc finger and BTB domain containing 38 "GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006275,GO:0006355,GO:0006974,GO:0008327,GO:0042803,GO:0045892,GO:0045944,GO:0046872,GO:0072562" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of DNA replication|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|methyl-CpG binding|protein homodimerization activity|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|blood microparticle" ZBTB39 336.6600225 359.9832034 313.3368417 0.870420727 -0.200215183 0.513837742 1 3.065035409 2.623227152 9880 zinc finger and BTB domain containing 39 "GO:0000122,GO:0000978,GO:0001227,GO:0005515,GO:0005654,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding" ZBTB4 2018.935427 2019.443346 2018.427508 0.999496971 -0.0007259 0.999961144 1 15.80031957 15.5281076 57659 zinc finger and BTB domain containing 4 "GO:0000122,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006974,GO:0008327,GO:0010428,GO:0016604,GO:0019901,GO:0042803,GO:0043565,GO:0045892,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|methyl-CpG binding|methyl-CpNpG binding|nuclear body|protein kinase binding|protein homodimerization activity|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding" ZBTB40 866.1935174 1014.403536 717.9834991 0.707788837 -0.498609086 0.045498389 1 5.582845447 3.885353094 9923 zinc finger and BTB domain containing 40 "GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005634,GO:0006357,GO:0006974,GO:0030282,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|regulation of transcription by RNA polymerase II|cellular response to DNA damage stimulus|bone mineralization|metal ion binding" ZBTB41 890.1387423 923.8875278 856.3899568 0.926941788 -0.109449355 0.662565433 1 4.988989105 4.547117694 360023 zinc finger and BTB domain containing 41 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZBTB42 99.11230556 116.5263549 81.69825626 0.701113979 -0.512279096 0.276996461 1 1.65437547 1.140496316 100128927 zinc finger and BTB domain containing 42 "GO:0000122,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0006357,GO:0007517,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytoplasm|plasma membrane|regulation of transcription by RNA polymerase II|muscle organ development|metal ion binding" ZBTB ZBTB43 511.9955282 547.2577023 476.7333542 0.871131374 -0.199037789 0.46637671 1 4.235843039 3.62822902 23099 zinc finger and BTB domain containing 43 "GO:0000785,GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZBTB44 569.5755668 570.1468077 569.0043259 0.997996162 -0.002893827 0.998907834 1 3.514401391 3.448668196 29068 zinc finger and BTB domain containing 44 "GO:0003677,GO:0005515,GO:0005634,GO:0046872" DNA binding|protein binding|nucleus|metal ion binding ZBTB45 138.6285258 144.6175297 132.6395219 0.917174579 -0.124731726 0.779364142 1 2.457952791 2.216647957 84878 zinc finger and BTB domain containing 45 "GO:0000122,GO:0000978,GO:0001227,GO:0005515,GO:0005654,GO:0006357,GO:0007399,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|nervous system development|metal ion binding|sequence-specific double-stranded DNA binding" ZBTB46 269.2954316 269.4671956 269.1236677 0.998725159 -0.001840381 1 1 2.023208915 1.986817144 140685 zinc finger and BTB domain containing 46 "GO:0000785,GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0030853,GO:0045650,GO:0045656,GO:0046872,GO:2001199,GO:2001200" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|negative regulation of granulocyte differentiation|negative regulation of macrophage differentiation|negative regulation of monocyte differentiation|metal ion binding|negative regulation of dendritic cell differentiation|positive regulation of dendritic cell differentiation" ZBTB47 166.4473283 181.0320156 151.862641 0.838871735 -0.253477858 0.522133624 1 1.758526747 1.450493271 92999 zinc finger and BTB domain containing 47 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZBTB48 227.9411878 230.9718819 224.9104937 0.97375703 -0.038366257 0.925028554 1 4.162966846 3.985884746 3104 zinc finger and BTB domain containing 48 "GO:0000781,GO:0000976,GO:0000978,GO:0003691,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0010833,GO:0042802,GO:0045893,GO:0046872" "chromosome, telomeric region|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|double-stranded telomeric DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|telomere maintenance via telomere lengthening|identical protein binding|positive regulation of transcription, DNA-templated|metal ion binding" ZBTB ZBTB49 95.31234112 105.0818021 85.54288008 0.814059888 -0.296793162 0.542558601 1 1.907490697 1.526827463 166793 zinc finger and BTB domain containing 49 "GO:0000122,GO:0000978,GO:0001223,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0007050,GO:0008134,GO:0008285,GO:0015630,GO:0043565,GO:0045944,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|transcription coactivator binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|cell cycle arrest|transcription factor binding|negative regulation of cell population proliferation|microtubule cytoskeleton|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding" ZBTB5 508.8447184 515.0048719 502.684565 0.9760773 -0.034932689 0.905245816 1 4.595362561 4.410371501 9925 zinc finger and BTB domain containing 5 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZBTB6 474.535598 484.8328693 464.2383267 0.957522388 -0.062621876 0.827844422 1 6.312427214 5.943147365 10773 zinc finger and BTB domain containing 6 "GO:0000122,GO:0000978,GO:0001227,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|metal ion binding" ZBTB ZBTB7A 910.3877984 862.5031087 958.2724881 1.111036561 0.151906293 0.542211221 1 5.968647004 6.520417796 51341 zinc finger and BTB domain containing 7A "GO:0000122,GO:0000381,GO:0000978,GO:0000981,GO:0001222,GO:0001227,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005737,GO:0006110,GO:0006325,GO:0006338,GO:0006351,GO:0006357,GO:0016581,GO:0030183,GO:0030512,GO:0033613,GO:0034504,GO:0035035,GO:0035861,GO:0042981,GO:0043249,GO:0045444,GO:0045746,GO:0045892,GO:0046332,GO:0046872,GO:0050681,GO:0051090,GO:0051092,GO:0060766,GO:0070418,GO:0097680,GO:1990837,GO:2000677" "negative regulation of transcription by RNA polymerase II|regulation of alternative mRNA splicing, via spliceosome|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|transcription corepressor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|cytoplasm|regulation of glycolytic process|chromatin organization|chromatin remodeling|transcription, DNA-templated|regulation of transcription by RNA polymerase II|NuRD complex|B cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway|activating transcription factor binding|protein localization to nucleus|histone acetyltransferase binding|site of double-strand break|regulation of apoptotic process|erythrocyte maturation|fat cell differentiation|negative regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|SMAD binding|metal ion binding|androgen receptor binding|regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|negative regulation of androgen receptor signaling pathway|DNA-dependent protein kinase complex|double-strand break repair via classical nonhomologous end joining|sequence-specific double-stranded DNA binding|regulation of transcription regulatory region DNA binding" ZBTB ZBTB7B 667.4839122 692.9156458 642.0521786 0.926595008 -0.109989185 0.673781808 1 7.262300568 6.616607215 51043 zinc finger and BTB domain containing 7B "GO:0000122,GO:0000978,GO:0000981,GO:0000987,GO:0001228,GO:0001865,GO:0005515,GO:0005654,GO:0006357,GO:0006366,GO:0007398,GO:0007595,GO:0010628,GO:0031065,GO:0032620,GO:0032868,GO:0042803,GO:0042826,GO:0043372,GO:0043377,GO:0045944,GO:0046628,GO:0046872,GO:0051141,GO:0090336,GO:0120162,GO:1990837,GO:1990845,GO:2000320,GO:2000640" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|NK T cell differentiation|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|ectoderm development|lactation|positive regulation of gene expression|positive regulation of histone deacetylation|interleukin-17 production|response to insulin|protein homodimerization activity|histone deacetylase binding|positive regulation of CD4-positive, alpha-beta T cell differentiation|negative regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of insulin receptor signaling pathway|metal ion binding|negative regulation of NK T cell proliferation|positive regulation of brown fat cell differentiation|positive regulation of cold-induced thermogenesis|sequence-specific double-stranded DNA binding|adaptive thermogenesis|negative regulation of T-helper 17 cell differentiation|positive regulation of SREBP signaling pathway" ZBTB ZBTB8A 228.6199106 236.1739514 221.0658699 0.936029857 -0.095373546 0.793443732 1 1.781004623 1.639177285 653121 zinc finger and BTB domain containing 8A "GO:0000977,GO:0003674,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0046872" RNA polymerase II transcription regulatory region sequence-specific DNA binding|molecular_function|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding ZBTB8B 65.26425583 35.37407201 95.15443964 2.689948718 1.427578669 0.009782459 0.604180798 0.147131884 0.389154428 728116 zinc finger and BTB domain containing 8B "GO:0000785,GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZBTB8OS 290.1533991 287.1542316 293.1525666 1.020888896 0.029825866 0.937128855 1 5.230339104 5.250244222 339487 zinc finger and BTB domain containing 8 opposite strand "GO:0005515,GO:0005654,GO:0006388,GO:0046872,GO:0072669" "protein binding|nucleoplasm|tRNA splicing, via endonucleolytic cleavage and ligation|metal ion binding|tRNA-splicing ligase complex" ZBTB9 222.4963142 226.8102264 218.182402 0.961960161 -0.055950947 0.885460391 1 4.458359088 4.216997173 221504 zinc finger and BTB domain containing 9 "GO:0000977,GO:0005515,GO:0005634,GO:0006357,GO:0042802,GO:0046872" RNA polymerase II transcription regulatory region sequence-specific DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|identical protein binding|metal ion binding ZC2HC1A 822.4571197 825.0482089 819.8660305 0.993718939 -0.009090234 0.976511285 1 4.254643592 4.157171401 51101 zinc finger C2HC-type containing 1A "GO:0005515,GO:0046872" protein binding|metal ion binding ZC2HC1C 28.02197774 29.13158871 26.91236677 0.923820772 -0.11431511 0.927935804 1 0.675662472 0.613746035 79696 zinc finger C2HC-type containing 1C "GO:0005515,GO:0046872" protein binding|metal ion binding ZC3H10 141.784366 164.3853935 119.1833385 0.725023897 -0.463899548 0.263920944 1 1.152515281 0.821618467 84872 zinc finger CCCH-type containing 10 "GO:0000381,GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0010608,GO:0035198,GO:0046872,GO:1903799" "regulation of alternative mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|cytoplasm|posttranscriptional regulation of gene expression|miRNA binding|metal ion binding|negative regulation of production of miRNAs involved in gene silencing by miRNA" ZC3H11A 4011.275519 4047.210003 3975.341034 0.982242342 -0.025849079 0.914598779 1 40.58477253 39.19701061 9877 zinc finger CCCH-type containing 11A "GO:0000346,GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0006405,GO:0006406,GO:0016973,GO:0031124,GO:0046872" transcription export complex|RNA binding|mRNA binding|protein binding|nucleoplasm|RNA export from nucleus|mRNA export from nucleus|poly(A)+ mRNA export from nucleus|mRNA 3'-end processing|metal ion binding ZC3H11B 114.8921209 114.4455271 115.3387147 1.007804478 0.011215772 1 1 1.281256018 1.26964814 643136 zinc finger CCCH-type containing 11B "GO:0000346,GO:0003729,GO:0016973,GO:0046872" transcription export complex|mRNA binding|poly(A)+ mRNA export from nucleus|metal ion binding ZC3H12A 1075.778393 1280.74949 870.8072961 0.679920081 -0.556562916 0.022768868 0.83252478 24.41115941 16.31989849 80149 zinc finger CCCH-type containing 12A "GO:0000294,GO:0000932,GO:0001525,GO:0001933,GO:0002230,GO:0002757,GO:0003677,GO:0003682,GO:0003723,GO:0003729,GO:0003730,GO:0004521,GO:0004532,GO:0004540,GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005791,GO:0005856,GO:0006915,GO:0006954,GO:0006974,GO:0007399,GO:0010468,GO:0010508,GO:0010595,GO:0010628,GO:0010629,GO:0010656,GO:0010884,GO:0010942,GO:0016032,GO:0016579,GO:0018215,GO:0030154,GO:0030867,GO:0032088,GO:0032689,GO:0032691,GO:0032715,GO:0032720,GO:0032991,GO:0034599,GO:0035198,GO:0035613,GO:0035925,GO:0036464,GO:0042149,GO:0042307,GO:0042406,GO:0043022,GO:0043031,GO:0043124,GO:0044828,GO:0045019,GO:0045600,GO:0045766,GO:0045944,GO:0046872,GO:0050852,GO:0051259,GO:0051607,GO:0055118,GO:0061014,GO:0061158,GO:0071222,GO:0071347,GO:0071356,GO:0090501,GO:0090502,GO:0090503,GO:0098586,GO:1900016,GO:1900119,GO:1900745,GO:1901223,GO:1903003,GO:1903799,GO:1903936,GO:1904637,GO:1990869,GO:2000320,GO:2000379,GO:2000627" "nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay|P-body|angiogenesis|negative regulation of protein phosphorylation|positive regulation of defense response to virus by host|immune response-activating signal transduction|DNA binding|chromatin binding|RNA binding|mRNA binding|mRNA 3'-UTR binding|endoribonuclease activity|exoribonuclease activity|ribonuclease activity|thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytoplasm|rough endoplasmic reticulum|cytoskeleton|apoptotic process|inflammatory response|cellular response to DNA damage stimulus|nervous system development|regulation of gene expression|positive regulation of autophagy|positive regulation of endothelial cell migration|positive regulation of gene expression|negative regulation of gene expression|negative regulation of muscle cell apoptotic process|positive regulation of lipid storage|positive regulation of cell death|viral process|protein deubiquitination|protein phosphopantetheinylation|cell differentiation|rough endoplasmic reticulum membrane|negative regulation of NF-kappaB transcription factor activity|negative regulation of interferon-gamma production|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|protein-containing complex|cellular response to oxidative stress|miRNA binding|RNA stem-loop binding|mRNA 3'-UTR AU-rich region binding|cytoplasmic ribonucleoprotein granule|cellular response to glucose starvation|positive regulation of protein import into nucleus|extrinsic component of endoplasmic reticulum membrane|ribosome binding|negative regulation of macrophage activation|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation by host of viral genome replication|negative regulation of nitric oxide biosynthetic process|positive regulation of fat cell differentiation|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|metal ion binding|T cell receptor signaling pathway|protein complex oligomerization|defense response to virus|negative regulation of cardiac muscle contraction|positive regulation of mRNA catabolic process|3'-UTR-mediated mRNA destabilization|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to tumor necrosis factor|RNA phosphodiester bond hydrolysis|RNA phosphodiester bond hydrolysis, endonucleolytic|RNA phosphodiester bond hydrolysis, exonucleolytic|cellular response to virus|negative regulation of cytokine production involved in inflammatory response|positive regulation of execution phase of apoptosis|positive regulation of p38MAPK cascade|negative regulation of NIK/NF-kappaB signaling|positive regulation of protein deubiquitination|negative regulation of production of miRNAs involved in gene silencing by miRNA|cellular response to sodium arsenite|cellular response to ionomycin|cellular response to chemokine|negative regulation of T-helper 17 cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of miRNA catabolic process" ZC3H12B 90.79905533 74.90979955 106.6883111 1.42422369 0.510175755 0.295182519 1 0.311719168 0.43652879 340554 zinc finger CCCH-type containing 12B "GO:0003729,GO:0004521,GO:0005634,GO:0036464,GO:0046872,GO:0090502" "mRNA binding|endoribonuclease activity|nucleus|cytoplasmic ribonucleoprotein granule|metal ion binding|RNA phosphodiester bond hydrolysis, endonucleolytic" ZC3H12C 1815.159075 2246.253573 1384.064577 0.616165776 -0.698609542 0.003293831 0.369206029 8.413701904 5.097484012 85463 zinc finger CCCH-type containing 12C "GO:0003674,GO:0003729,GO:0004521,GO:0005515,GO:0005575,GO:0005634,GO:0008150,GO:0036464,GO:0046872,GO:0090502" "molecular_function|mRNA binding|endoribonuclease activity|protein binding|cellular_component|nucleus|biological_process|cytoplasmic ribonucleoprotein granule|metal ion binding|RNA phosphodiester bond hydrolysis, endonucleolytic" ZC3H13 1617.798697 1657.379315 1578.21808 0.952237104 -0.07060725 0.768591002 1 6.75252217 6.32240478 23091 zinc finger CCCH-type containing 13 "GO:0003723,GO:0005515,GO:0005654,GO:0006397,GO:0007275,GO:0008380,GO:0016607,GO:0036396,GO:0046872,GO:0080009,GO:2000036" RNA binding|protein binding|nucleoplasm|mRNA processing|multicellular organism development|RNA splicing|nuclear speck|RNA N6-methyladenosine methyltransferase complex|metal ion binding|mRNA methylation|regulation of stem cell population maintenance ZC3H14 1929.16611 2072.504454 1785.827766 0.861676202 -0.214782256 0.364549308 1 4.331026455 3.669493423 79882 zinc finger CCCH-type containing 14 "GO:0003723,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0008143,GO:0016607,GO:0032839,GO:0043488,GO:0046872,GO:1900364,GO:1904115,GO:1990904" RNA binding|protein binding|nucleus|nucleolus|cytoplasm|poly(A) binding|nuclear speck|dendrite cytoplasm|regulation of mRNA stability|metal ion binding|negative regulation of mRNA polyadenylation|axon cytoplasm|ribonucleoprotein complex ZC3H15 1945.8039 1928.927338 1962.680462 1.01749839 0.025026512 0.91802388 1 50.48715392 50.51098046 55854 zinc finger CCCH-type containing 15 "GO:0002181,GO:0003723,GO:0005515,GO:0005634,GO:0005829,GO:0019221,GO:0043547,GO:0045296,GO:0046872" cytoplasmic translation|RNA binding|protein binding|nucleus|cytosol|cytokine-mediated signaling pathway|positive regulation of GTPase activity|cadherin binding|metal ion binding ZC3H18 1231.277452 1300.517353 1162.037551 0.89351945 -0.16242896 0.502594695 1 17.54898126 15.41796657 124245 zinc finger CCCH-type containing 18 "GO:0003723,GO:0005515,GO:0016607,GO:0032991,GO:0046872" RNA binding|protein binding|nuclear speck|protein-containing complex|metal ion binding ZC3H3 624.3954405 684.5923348 564.1985462 0.824137983 -0.279042191 0.285599495 1 8.622948945 6.987582104 23144 zinc finger CCCH-type containing 3 "GO:0003674,GO:0003677,GO:0005634,GO:0005847,GO:0031124,GO:0032927,GO:0046872,GO:0051028,GO:0070412,GO:1900363" molecular_function|DNA binding|nucleus|mRNA cleavage and polyadenylation specificity factor complex|mRNA 3'-end processing|positive regulation of activin receptor signaling pathway|metal ion binding|mRNA transport|R-SMAD binding|regulation of mRNA polyadenylation ZC3H4 469.7939849 524.3685969 415.219373 0.791846376 -0.336707531 0.225039431 1 2.400256305 1.868829716 23211 zinc finger CCCH-type containing 4 "GO:0000785,GO:0000981,GO:0003723,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0046872" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|metal ion binding" ZC3H6 296.5990576 292.356301 300.8418142 1.029024561 0.041277417 0.906985207 1 1.351803713 1.367762065 376940 zinc finger CCCH-type containing 6 "GO:0000785,GO:0000981,GO:0003674,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" ZC3H7A 993.9278799 1062.262574 925.5931856 0.871341237 -0.198690273 0.420140272 1 12.02099263 10.29911191 29066 zinc finger CCCH-type containing 7A "GO:0003723,GO:0005634,GO:0010608,GO:0035196,GO:0035198,GO:0046872" RNA binding|nucleus|posttranscriptional regulation of gene expression|production of miRNAs involved in gene silencing by miRNA|miRNA binding|metal ion binding ZC3H7B 4392.938223 4932.602218 3853.274228 0.781184871 -0.356264085 0.135954132 1 44.55719611 34.22495267 23264 zinc finger CCCH-type containing 7B "GO:0003723,GO:0005515,GO:0005634,GO:0010608,GO:0016032,GO:0035196,GO:0035198,GO:0046872" RNA binding|protein binding|nucleus|posttranscriptional regulation of gene expression|viral process|production of miRNAs involved in gene silencing by miRNA|miRNA binding|metal ion binding ZC3H8 271.6781999 319.407062 223.9493377 0.701140846 -0.512223811 0.115679975 1 2.732633513 1.883899962 84524 zinc finger CCCH-type containing 8 "GO:0000785,GO:0000981,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006915,GO:0008023,GO:0015030,GO:0016604,GO:0033085,GO:0035327,GO:0035363,GO:0042795,GO:0042796,GO:0043029,GO:0045892,GO:0045945,GO:0046677,GO:0046872,GO:0070245" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA binding|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|apoptotic process|transcription elongation factor complex|Cajal body|nuclear body|negative regulation of T cell differentiation in thymus|transcriptionally active chromatin|histone locus body|snRNA transcription by RNA polymerase II|snRNA transcription by RNA polymerase III|T cell homeostasis|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase III|response to antibiotic|metal ion binding|positive regulation of thymocyte apoptotic process" other ZC3HAV1 1208.96769 1307.80025 1110.135129 0.848856795 -0.236406908 0.328943996 1 8.471282405 7.070575565 56829 "zinc finger CCCH-type containing, antiviral 1" "GO:0003723,GO:0003950,GO:0005515,GO:0005634,GO:0005829,GO:0006471,GO:0009615,GO:0045071,GO:0045087,GO:0045296,GO:0046872,GO:0051607,GO:0061014,GO:0070212,GO:0070403,GO:1990404" RNA binding|NAD+ ADP-ribosyltransferase activity|protein binding|nucleus|cytosol|protein ADP-ribosylation|response to virus|negative regulation of viral genome replication|innate immune response|cadherin binding|metal ion binding|defense response to virus|positive regulation of mRNA catabolic process|protein poly-ADP-ribosylation|NAD+ binding|protein ADP-ribosylase activity ZC3HAV1L 292.3084544 305.8816815 278.7352272 0.911251782 -0.134078365 0.679737462 1 3.434534642 3.077354089 92092 "zinc finger CCCH-type containing, antiviral 1 like" GO:0005829 cytosol ZC3HC1 510.975236 495.2370081 526.7134639 1.063558367 0.08889921 0.749428871 1 4.671242297 4.885003756 51530 zinc finger C3HC-type containing 1 "GO:0005515,GO:0005634,GO:0005654,GO:0007049,GO:0008270,GO:0016567,GO:0019901,GO:0031965,GO:0051301,GO:2001240" protein binding|nucleus|nucleoplasm|cell cycle|zinc ion binding|protein ubiquitination|protein kinase binding|nuclear membrane|cell division|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ZC4H2 680.6979058 598.2379825 763.1578291 1.275675987 0.351261941 0.172354394 1 11.25374043 14.11589611 55906 zinc finger C4H2-type containing "GO:0005515,GO:0005634,GO:0005737,GO:0007399,GO:0007528,GO:0021522,GO:0045211,GO:0045666,GO:0046872" protein binding|nucleus|cytoplasm|nervous system development|neuromuscular junction development|spinal cord motor neuron differentiation|postsynaptic membrane|positive regulation of neuron differentiation|metal ion binding ZCCHC10 192.9533446 195.5978099 190.3088793 0.972960174 -0.039547342 0.929348551 1 4.70423417 4.500442058 54819 zinc finger CCHC-type containing 10 "GO:0003676,GO:0005515,GO:0008270" nucleic acid binding|protein binding|zinc ion binding ZCCHC12 7.367185523 4.161655531 10.57271552 2.540507122 1.345116509 0.341208165 1 0.101092356 0.252528218 170261 zinc finger CCHC-type containing 12 "GO:0003676,GO:0005515,GO:0005634,GO:0008270" nucleic acid binding|protein binding|nucleus|zinc ion binding ZCCHC14 626.6549058 642.9757795 610.3340321 0.949233317 -0.075165356 0.778275391 1 3.712879854 3.465413379 23174 zinc finger CCHC-type containing 14 "GO:0003676,GO:0005515,GO:0008270,GO:0035091" nucleic acid binding|protein binding|zinc ion binding|phosphatidylinositol binding ZCCHC17 686.2761432 668.9861265 703.5661598 1.05169021 0.072709801 0.781959813 1 13.93542546 14.41050639 51538 zinc finger CCHC-type containing 17 "GO:0003723,GO:0005515,GO:0005730,GO:0008270,GO:0042802,GO:0043489" RNA binding|protein binding|nucleolus|zinc ion binding|identical protein binding|RNA stabilization ZCCHC18 49.56369841 39.53572754 59.59166927 1.507286522 0.591953687 0.331253818 1 0.699121642 1.036143104 644353 zinc finger CCHC-type containing 18 "GO:0005634,GO:0046872" nucleus|metal ion binding ZCCHC2 345.9790881 390.155206 301.8029702 0.773545926 -0.370441146 0.219250811 1 2.904836254 2.209423343 54877 zinc finger CCHC-type containing 2 "GO:0003676,GO:0005737,GO:0008270,GO:0035091" nucleic acid binding|cytoplasm|zinc ion binding|phosphatidylinositol binding ZCCHC24 1100.685388 1089.313335 1112.057441 1.020879306 0.029812312 0.906468571 1 10.94196323 10.98350191 219654 zinc finger CCHC-type containing 24 "GO:0003723,GO:0008270" RNA binding|zinc ion binding ZCCHC3 361.4469021 367.2661006 355.6277037 0.968310724 -0.046458023 0.885138589 1 7.122208133 6.781106749 85364 zinc finger CCHC-type containing 3 "GO:0002218,GO:0003690,GO:0003723,GO:0005515,GO:0005737,GO:0008270,GO:0009597,GO:0032481,GO:0045087,GO:0051607,GO:0071360,GO:1900246" activation of innate immune response|double-stranded DNA binding|RNA binding|protein binding|cytoplasm|zinc ion binding|detection of virus|positive regulation of type I interferon production|innate immune response|defense response to virus|cellular response to exogenous dsRNA|positive regulation of RIG-I signaling pathway ZCCHC4 509.8555642 491.0753526 528.6357758 1.076486069 0.106329649 0.701092597 1 3.918042908 4.147140798 29063 zinc finger CCHC-type containing 4 "GO:0003676,GO:0005730,GO:0005737,GO:0008270,GO:0008988,GO:0031167,GO:0045727,GO:1904047" nucleic acid binding|nucleolus|cytoplasm|zinc ion binding|rRNA (adenine-N6-)-methyltransferase activity|rRNA methylation|positive regulation of translation|S-adenosyl-L-methionine binding ZCCHC7 908.7623965 920.7662861 896.7585069 0.973926305 -0.038115484 0.882231383 1 5.149282657 4.931102233 84186 zinc finger CCHC-type containing 7 "GO:0003723,GO:0005515,GO:0005730,GO:0005829,GO:0008270" RNA binding|protein binding|nucleolus|cytosol|zinc ion binding hsa03018 RNA degradation ZCCHC8 779.2195786 888.5134558 669.9257013 0.753984869 -0.407392524 0.106437217 1 10.52571146 7.803425158 55596 zinc finger CCHC-type containing 8 "GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0008270,GO:0016076,GO:0016604,GO:0031499,GO:0034470,GO:0071013" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|zinc ion binding|snRNA catabolic process|nuclear body|TRAMP complex|ncRNA processing|catalytic step 2 spliceosome" ZCCHC9 676.4865605 613.8441908 739.1289302 1.204098599 0.267953534 0.298913654 1 22.97316708 27.19907289 84240 zinc finger CCHC-type containing 9 "GO:0003723,GO:0005654,GO:0005730,GO:0008270,GO:0010923" RNA binding|nucleoplasm|nucleolus|zinc ion binding|negative regulation of phosphatase activity ZCRB1 867.9830799 846.8969005 889.0692593 1.049796332 0.070109461 0.78235198 1 24.82006098 25.61999694 85437 zinc finger CCHC-type and RNA binding motif containing 1 "GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005689,GO:0008270,GO:0008380" "mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|U12-type spliceosomal complex|zinc ion binding|RNA splicing" ZCWPW1 27.94271981 27.05076095 28.83467868 1.065947044 0.092135768 0.954076963 1 0.335342484 0.351475766 55063 zinc finger CW-type and PWWP domain containing 1 "GO:0005634,GO:0005694,GO:0007127,GO:0007129,GO:0007283,GO:0008270,GO:0008327,GO:0030154,GO:0035064,GO:0045911,GO:2000781" nucleus|chromosome|meiosis I|homologous chromosome pairing at meiosis|spermatogenesis|zinc ion binding|methyl-CpG binding|cell differentiation|methylated histone binding|positive regulation of DNA recombination|positive regulation of double-strand break repair ZCWPW2 45.19886764 38.49531366 51.90242162 1.348278964 0.431119027 0.502730294 1 0.293405333 0.388972537 152098 zinc finger CW-type and PWWP domain containing 2 "GO:0005515,GO:0008270,GO:0035064" protein binding|zinc ion binding|methylated histone binding ZDBF2 821.0499843 838.5735894 803.5263792 0.95820616 -0.061592006 0.810248316 1 4.235178502 3.990266083 57683 zinc finger DBF-type containing 2 "GO:0003676,GO:0008270" nucleic acid binding|zinc ion binding ZDHHC1 68.57358145 71.7885579 65.35860501 0.910432065 -0.135376725 0.824365503 1 1.440309546 1.289361098 29800 zinc finger DHHC-type containing 1 "GO:0002230,GO:0003677,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0006612,GO:0010008,GO:0016021,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0032461,GO:0070062,GO:0140374,GO:1905668" positive regulation of defense response to virus by host|DNA binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein targeting to membrane|endosome membrane|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|positive regulation of protein oligomerization|extracellular exosome|antiviral innate immune response|positive regulation of protein localization to endosome ZDHHC11 10.88974722 8.323311061 13.45618338 1.616686351 0.693039812 0.572357607 1 0.059857137 0.095150898 79844 zinc finger DHHC-type containing 11 "GO:0002230,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0006612,GO:0010008,GO:0016021,GO:0018215,GO:0018230,GO:0019706,GO:0035591,GO:0140374" positive regulation of defense response to virus by host|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein targeting to membrane|endosome membrane|integral component of membrane|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein-cysteine S-palmitoyltransferase activity|signaling adaptor activity|antiviral innate immune response ZDHHC12 611.851952 506.6815608 717.0223432 1.415134077 0.500938748 0.05592793 1 20.56324233 28.61280014 84885 zinc finger DHHC-type palmitoyltransferase 12 "GO:0000139,GO:0005783,GO:0005789,GO:0005794,GO:0006612,GO:0016021,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0032230,GO:0097116" "Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein targeting to membrane|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|positive regulation of synaptic transmission, GABAergic|gephyrin clustering involved in postsynaptic density assembly" ZDHHC13 570.2888882 588.8742576 551.7035187 0.936878309 -0.094066426 0.728115082 1 11.62246184 10.70662254 54503 zinc finger DHHC-type palmitoyltransferase 13 "GO:0000139,GO:0005783,GO:0015095,GO:0016020,GO:0016021,GO:0016409,GO:0018215,GO:0018345,GO:0019706,GO:0030659,GO:0030660,GO:0043123,GO:1903830" Golgi membrane|endoplasmic reticulum|magnesium ion transmembrane transporter activity|membrane|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|cytoplasmic vesicle membrane|Golgi-associated vesicle membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|magnesium ion transmembrane transport ZDHHC14 62.44495463 74.90979955 49.98010971 0.667203891 -0.583800393 0.294239636 1 0.430983002 0.282741717 79683 zinc finger DHHC-type palmitoyltransferase 14 "GO:0005783,GO:0005789,GO:0005794,GO:0006612,GO:0016021,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0032580" endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein targeting to membrane|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|Golgi cisterna membrane ZDHHC16 1869.28379 1799.916017 1938.651563 1.0770789 0.107123936 0.652397773 1 44.57457528 47.20694657 84287 zinc finger DHHC-type palmitoyltransferase 16 "GO:0001654,GO:0005515,GO:0005789,GO:0005794,GO:0006915,GO:0006974,GO:0007507,GO:0016021,GO:0016409,GO:0018215,GO:0018345,GO:0019706,GO:0021537" eye development|protein binding|endoplasmic reticulum membrane|Golgi apparatus|apoptotic process|cellular response to DNA damage stimulus|heart development|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|telencephalon development ZDHHC17 976.0772976 1035.211813 916.942782 0.885753785 -0.175022369 0.478773348 1 11.66294107 10.15762737 23390 zinc finger DHHC-type palmitoyltransferase 17 "GO:0000139,GO:0005102,GO:0005515,GO:0005794,GO:0007409,GO:0015095,GO:0016021,GO:0016235,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0030659,GO:0030660,GO:0042734,GO:0042802,GO:0042953,GO:0042995,GO:0043123,GO:0043231,GO:0051386,GO:0070372,GO:1903830" Golgi membrane|signaling receptor binding|protein binding|Golgi apparatus|axonogenesis|magnesium ion transmembrane transporter activity|integral component of membrane|aggresome|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|cytoplasmic vesicle membrane|Golgi-associated vesicle membrane|presynaptic membrane|identical protein binding|lipoprotein transport|cell projection|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|regulation of neurotrophin TRK receptor signaling pathway|regulation of ERK1 and ERK2 cascade|magnesium ion transmembrane transport ZDHHC18 687.609051 640.8949517 734.3231504 1.14577771 0.196327177 0.446526887 1 6.77966019 7.637996845 84243 zinc finger DHHC-type palmitoyltransferase 18 "GO:0000139,GO:0005783,GO:0005794,GO:0006612,GO:0016021,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706" Golgi membrane|endoplasmic reticulum|Golgi apparatus|protein targeting to membrane|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity ZDHHC2 732.8179795 654.4203322 811.2156269 1.239594167 0.309867872 0.223743998 1 8.681384627 10.5813164 51201 zinc finger DHHC-type palmitoyltransferase 2 "GO:0000139,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005887,GO:0006612,GO:0014069,GO:0016188,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0022407,GO:0042176,GO:0042803,GO:0044267,GO:0048168,GO:0055038,GO:0072659,GO:0098837,GO:1900273,GO:1903076,GO:1903539,GO:1904719,GO:1905751" Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|protein targeting to membrane|postsynaptic density|synaptic vesicle maturation|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|regulation of cell-cell adhesion|regulation of protein catabolic process|protein homodimerization activity|cellular protein metabolic process|regulation of neuronal synaptic plasticity|recycling endosome membrane|protein localization to plasma membrane|postsynaptic recycling endosome|positive regulation of long-term synaptic potentiation|regulation of protein localization to plasma membrane|protein localization to postsynaptic membrane|positive regulation of AMPA glutamate receptor clustering|positive regulation of endosome to plasma membrane protein transport ZDHHC20 3177.711614 3056.735987 3298.687241 1.079153468 0.109900047 0.643405736 1 29.53691501 31.34148158 253832 zinc finger DHHC-type palmitoyltransferase 20 "GO:0005783,GO:0005794,GO:0005886,GO:0006612,GO:0008270,GO:0016020,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0030173,GO:0043231,GO:0048471" endoplasmic reticulum|Golgi apparatus|plasma membrane|protein targeting to membrane|zinc ion binding|membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|integral component of Golgi membrane|intracellular membrane-bounded organelle|perinuclear region of cytoplasm ZDHHC21 610.9644092 622.1675018 599.7613165 0.963986892 -0.052914565 0.845787551 1 3.448684678 3.26885604 340481 zinc finger DHHC-type palmitoyltransferase 21 "GO:0000139,GO:0001942,GO:0003056,GO:0005515,GO:0005783,GO:0005794,GO:0005886,GO:0006612,GO:0016021,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0048733,GO:0050999,GO:0071875,GO:1903140,GO:1904997" Golgi membrane|hair follicle development|regulation of vascular associated smooth muscle contraction|protein binding|endoplasmic reticulum|Golgi apparatus|plasma membrane|protein targeting to membrane|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|sebaceous gland development|regulation of nitric-oxide synthase activity|adrenergic receptor signaling pathway|regulation of establishment of endothelial barrier|regulation of leukocyte adhesion to arterial endothelial cell ZDHHC23 265.1878819 325.6495453 204.7262186 0.628670365 -0.669624337 0.041313477 1 2.537497111 1.5685549 254887 zinc finger DHHC-type palmitoyltransferase 23 "GO:0000139,GO:0003674,GO:0005515,GO:0005575,GO:0005783,GO:0005794,GO:0006612,GO:0016021,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0072659" Golgi membrane|molecular_function|protein binding|cellular_component|endoplasmic reticulum|Golgi apparatus|protein targeting to membrane|integral component of membrane|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|protein localization to plasma membrane ZDHHC24 417.9368371 412.0038975 423.8697766 1.028800405 0.040963116 0.894497772 1 2.583770949 2.61370348 254359 zinc finger DHHC-type containing 24 "GO:0005515,GO:0005783,GO:0005794,GO:0006612,GO:0016021,GO:0018215,GO:0018230,GO:0019706" protein binding|endoplasmic reticulum|Golgi apparatus|protein targeting to membrane|integral component of membrane|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein-cysteine S-palmitoyltransferase activity ZDHHC3 1491.580911 1523.165924 1459.995897 0.958527153 -0.061108794 0.800272527 1 8.889825669 8.378549564 51304 zinc finger DHHC-type palmitoyltransferase 3 "GO:0000139,GO:0005783,GO:0005794,GO:0006612,GO:0008277,GO:0016020,GO:0016021,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0032230,GO:0036462,GO:0042803,GO:0044873,GO:0072659,GO:1902685,GO:1903546" "Golgi membrane|endoplasmic reticulum|Golgi apparatus|protein targeting to membrane|regulation of G protein-coupled receptor signaling pathway|membrane|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|positive regulation of synaptic transmission, GABAergic|TRAIL-activated apoptotic signaling pathway|protein homodimerization activity|lipoprotein localization to membrane|protein localization to plasma membrane|positive regulation of receptor localization to synapse|protein localization to photoreceptor outer segment" ZDHHC4 863.2911566 862.5031087 864.0792044 1.001827351 0.002633904 0.996923172 1 22.73096578 22.39143622 55146 zinc finger DHHC-type palmitoyltransferase 4 "GO:0000139,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0006612,GO:0016021,GO:0018215,GO:0018230,GO:0019706" Golgi membrane|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|protein targeting to membrane|integral component of membrane|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein-cysteine S-palmitoyltransferase activity ZDHHC5 2771.401155 2912.118458 2630.683852 0.903357432 -0.146631162 0.535781864 1 32.31740691 28.70564482 25921 zinc finger DHHC-type palmitoyltransferase 5 "GO:0005515,GO:0005886,GO:0016020,GO:0016021,GO:0016409,GO:0018215,GO:0018345,GO:0019706,GO:0030425,GO:0045335,GO:0062208,GO:1903078,GO:1905171" protein binding|plasma membrane|membrane|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|dendrite|phagocytic vesicle|positive regulation of pattern recognition receptor signaling pathway|positive regulation of protein localization to plasma membrane|positive regulation of protein localization to phagocytic vesicle ZDHHC6 610.7612339 629.450399 592.0720689 0.940617513 -0.088319901 0.74089004 1 8.306778169 7.682752664 64429 zinc finger DHHC-type palmitoyltransferase 6 "GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0006612,GO:0010636,GO:0016021,GO:0016409,GO:0016747,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0043543" "protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein targeting to membrane|positive regulation of mitochondrial fusion|integral component of membrane|palmitoyltransferase activity|transferase activity, transferring acyl groups other than amino-acyl groups|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|protein acylation" ZDHHC7 2204.948058 2146.37384 2263.522276 1.054579698 0.076668129 0.7470816 1 31.21199645 32.36474085 55625 zinc finger DHHC-type palmitoyltransferase 7 "GO:0000139,GO:0005654,GO:0005783,GO:0005794,GO:0006612,GO:0008277,GO:0009895,GO:0016021,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0030859,GO:0044381,GO:0150106,GO:1902044,GO:1903076" Golgi membrane|nucleoplasm|endoplasmic reticulum|Golgi apparatus|protein targeting to membrane|regulation of G protein-coupled receptor signaling pathway|negative regulation of catabolic process|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|polarized epithelial cell differentiation|glucose import in response to insulin stimulus|regulation of protein localization to cell-cell junction|regulation of Fas signaling pathway|regulation of protein localization to plasma membrane ZDHHC8 1334.368974 1281.789903 1386.948044 1.082040076 0.113753934 0.637621084 1 13.5485782 14.41478759 29801 zinc finger DHHC-type palmitoyltransferase 8 "GO:0000139,GO:0005794,GO:0005829,GO:0007626,GO:0010875,GO:0016021,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0031966,GO:0034380,GO:1903078" Golgi membrane|Golgi apparatus|cytosol|locomotory behavior|positive regulation of cholesterol efflux|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|mitochondrial membrane|high-density lipoprotein particle assembly|positive regulation of protein localization to plasma membrane ZDHHC9 1872.999466 1821.764709 1924.234224 1.056247393 0.07894778 0.740542056 1 18.10507155 18.80342984 51114 zinc finger DHHC-type palmitoyltransferase 9 "GO:0002178,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006612,GO:0016021,GO:0016409,GO:0018215,GO:0018230,GO:0018345,GO:0019706,GO:0031228,GO:0043849" palmitoyltransferase complex|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|protein targeting to membrane|integral component of membrane|palmitoyltransferase activity|protein phosphopantetheinylation|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|intrinsic component of Golgi membrane|Ras palmitoyltransferase activity ZEB1 984.3861318 988.3931885 980.3790751 0.991891776 -0.011745376 0.966500942 1 6.433556273 6.274607612 6935 zinc finger E-box binding homeobox 1 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007399,GO:0008270,GO:0019221,GO:0030154,GO:0045602,GO:0045666,GO:0045892,GO:0048856,GO:0070888" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|nervous system development|zinc ion binding|cytokine-mediated signaling pathway|cell differentiation|negative regulation of endothelial cell differentiation|positive regulation of neuron differentiation|negative regulation of transcription, DNA-templated|anatomical structure development|E-box binding" "hsa05202,hsa05206,hsa05215" Transcriptional misregulation in cancer|MicroRNAs in cancer|Prostate cancer Homeobox ZEB2 871.8126125 884.3518002 859.2734247 0.971642082 -0.04150312 0.872141525 1 5.094034561 4.866753858 9839 zinc finger E-box binding homeobox 2 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0007399,GO:0019208,GO:0043565,GO:0045636,GO:0045944,GO:0046872,GO:0048023,GO:0048066,GO:0048856,GO:0050790,GO:0097324,GO:1903056" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|nervous system development|phosphatase regulator activity|sequence-specific DNA binding|positive regulation of melanocyte differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of melanin biosynthetic process|developmental pigmentation|anatomical structure development|regulation of catalytic activity|melanocyte migration|regulation of melanosome organization" hsa05206 MicroRNAs in cancer ZER1 887.4043438 852.0989699 922.7097178 1.082866839 0.114855844 0.646959566 1 9.384018971 9.991601623 10444 zyg-11 related cell cycle regulator "GO:0006515,GO:0031462,GO:0032436" protein quality control for misfolded or incompletely synthesized proteins|Cul2-RING ubiquitin ligase complex|positive regulation of proteasomal ubiquitin-dependent protein catabolic process ZFAND1 1869.927914 1791.592706 1948.263123 1.087447563 0.120945836 0.61078053 1 42.58975942 45.53912587 79752 zinc finger AN1-type containing 1 "GO:0005515,GO:0008270,GO:0010494,GO:0034599,GO:0034605,GO:0035617,GO:0070628,GO:0071470,GO:0090316,GO:1903843" protein binding|zinc ion binding|cytoplasmic stress granule|cellular response to oxidative stress|cellular response to heat|stress granule disassembly|proteasome binding|cellular response to osmotic stress|positive regulation of intracellular protein transport|cellular response to arsenite ion ZFAND2A 359.3711048 350.6194785 368.1227311 1.049920936 0.070280691 0.822027606 1 4.278965734 4.41739854 90637 zinc finger AN1-type containing 2A "GO:0005515,GO:0005634,GO:0005737,GO:0008270" protein binding|nucleus|cytoplasm|zinc ion binding ZFAND2B 272.7833948 260.1034707 285.4633189 1.097499077 0.134219726 0.687882172 1 11.55807176 12.47270724 130617 zinc finger AN1-type containing 2B "GO:0000502,GO:0005515,GO:0005783,GO:0005789,GO:0006616,GO:0008270,GO:0031225,GO:0036435,GO:0043130,GO:0043161,GO:0043567,GO:0045047" "proteasome complex|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|SRP-dependent cotranslational protein targeting to membrane, translocation|zinc ion binding|anchored component of membrane|K48-linked polyubiquitin modification-dependent protein binding|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of insulin-like growth factor receptor signaling pathway|protein targeting to ER" ZFAND3 1341.751251 1248.496659 1435.005842 1.14938701 0.20086465 0.403592901 1 18.26479497 20.64202334 60685 zinc finger AN1-type containing 3 "GO:0003677,GO:0005515,GO:0008270" DNA binding|protein binding|zinc ion binding ZFAND4 168.9294761 183.1128433 154.7461089 0.845086047 -0.24282985 0.537919577 1 1.650742551 1.371675735 93550 zinc finger AN1-type containing 4 GO:0008270 zinc ion binding ZFAND5 3437.586757 3646.650659 3228.522856 0.885339222 -0.175697759 0.459198279 1 22.48844966 19.5767412 7763 zinc finger AN1-type containing 5 "GO:0001701,GO:0001944,GO:0003016,GO:0003674,GO:0003677,GO:0005515,GO:0005575,GO:0005737,GO:0008150,GO:0008270,GO:0010761,GO:0048008,GO:0048705,GO:0048745,GO:0060324" in utero embryonic development|vasculature development|respiratory system process|molecular_function|DNA binding|protein binding|cellular_component|cytoplasm|biological_process|zinc ion binding|fibroblast migration|platelet-derived growth factor receptor signaling pathway|skeletal system morphogenesis|smooth muscle tissue development|face development ZFAND6 1383.060221 1399.356672 1366.763769 0.976708652 -0.033999818 0.890156694 1 16.78981423 16.12434584 54469 zinc finger AN1-type containing 6 "GO:0003674,GO:0003677,GO:0005515,GO:0005575,GO:0005829,GO:0006625,GO:0006915,GO:0008270,GO:0031593,GO:0043066,GO:0043122,GO:0071356" molecular_function|DNA binding|protein binding|cellular_component|cytosol|protein targeting to peroxisome|apoptotic process|zinc ion binding|polyubiquitin modification-dependent protein binding|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|cellular response to tumor necrosis factor ZFAT 223.3385833 223.6889848 222.9881818 0.996867065 -0.004526964 1 1 0.603135957 0.591185328 57623 zinc finger and AT-hook domain containing "GO:0000978,GO:0000981,GO:0001228,GO:0002244,GO:0005634,GO:0005829,GO:0006355,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|hematopoietic progenitor cell differentiation|nucleus|cytosol|regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZFC3H1 2857.099363 2626.00464 3088.194087 1.17600481 0.233893961 0.323009488 1 19.91545278 23.02875509 196441 zinc finger C3H1-type containing "GO:0000178,GO:0005515,GO:0005615,GO:0005634,GO:0005730,GO:0006396,GO:0046872" exosome (RNase complex)|protein binding|extracellular space|nucleus|nucleolus|RNA processing|metal ion binding ZFHX2 9.368755362 6.242483296 12.49502743 2.001611672 1.001162108 0.427900976 1 0.022422255 0.04412963 85446 zinc finger homeobox 2 "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0007420,GO:0008270,GO:0030534,GO:0045664,GO:0051930" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|brain development|zinc ion binding|adult behavior|regulation of neuron differentiation|regulation of sensory perception of pain" ZFHX3 477.2454588 518.1261136 436.364804 0.842198053 -0.247768555 0.37138377 1 1.383748106 1.145888738 463 zinc finger homeobox 3 "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006355,GO:0006357,GO:0007050,GO:0007420,GO:0007517,GO:0008270,GO:0016604,GO:0019899,GO:0032922,GO:0045664,GO:0045785,GO:0045893,GO:0045944,GO:0071559,GO:1904059" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|cell cycle arrest|brain development|muscle organ development|zinc ion binding|nuclear body|enzyme binding|circadian regulation of gene expression|regulation of neuron differentiation|positive regulation of cell adhesion|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|response to transforming growth factor beta|regulation of locomotor rhythm" hsa04550 Signaling pathways regulating pluripotency of stem cells Homeobox ZFHX4 1195.437279 1293.234456 1097.640102 0.848755689 -0.236578756 0.329023389 1 4.789891461 3.997417866 79776 zinc finger homeobox 4 "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0008270" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding" ZFP1 427.3502518 406.8018281 447.8986755 1.101024245 0.138846237 0.630054193 1 5.085562403 5.50563034 162239 ZFP1 zinc finger protein "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection ZFP14 155.0424046 159.183324 150.9014851 0.947972949 -0.077082204 0.862799023 1 1.081655391 1.008221704 57677 ZFP14 zinc finger protein "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZFP2 5.444873611 4.161655531 6.728091692 1.616686351 0.693039812 0.747994079 1 0.092157638 0.146496849 80108 ZFP2 zinc finger protein "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZFP28 2.482147817 2.080827765 2.883467868 1.385731158 0.470647391 1 1 0.014305031 0.019491217 140612 ZFP28 zinc finger protein "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZFP30 242.4673532 259.0630568 225.8716497 0.871879042 -0.197800095 0.565010904 1 2.180368901 1.869206987 22835 ZFP30 zinc finger protein "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZFP36 259.9121994 199.7594655 320.0649333 1.602251651 0.680100756 0.039832161 1 6.102344322 9.613878189 7538 ZFP36 ring finger protein "GO:0000122,GO:0000165,GO:0000178,GO:0000288,GO:0000289,GO:0000932,GO:0003677,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006402,GO:0009611,GO:0010494,GO:0010837,GO:0016032,GO:0019899,GO:0019901,GO:0019957,GO:0030014,GO:0031072,GO:0031086,GO:0032680,GO:0032703,GO:0032897,GO:0035278,GO:0035925,GO:0038066,GO:0042594,GO:0043488,GO:0044344,GO:0044877,GO:0045600,GO:0045616,GO:0045647,GO:0046872,GO:0051028,GO:0060213,GO:0061158,GO:0070063,GO:0070578,GO:0070935,GO:0071222,GO:0071356,GO:0071364,GO:0071385,GO:0071889,GO:0097011,GO:1900153,GO:1901835,GO:1902172,GO:1904246,GO:1904582,GO:1990904,GO:2000637" "negative regulation of transcription by RNA polymerase II|MAPK cascade|exosome (RNase complex)|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA poly(A) tail shortening|P-body|DNA binding|RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|cytosol|mRNA catabolic process|response to wounding|cytoplasmic stress granule|regulation of keratinocyte proliferation|viral process|enzyme binding|protein kinase binding|C-C chemokine binding|CCR4-NOT complex|heat shock protein binding|nuclear-transcribed mRNA catabolic process, deadenylation-independent decay|regulation of tumor necrosis factor production|negative regulation of interleukin-2 production|negative regulation of viral transcription|miRNA mediated inhibition of translation|mRNA 3'-UTR AU-rich region binding|p38MAPK cascade|response to starvation|regulation of mRNA stability|cellular response to fibroblast growth factor stimulus|protein-containing complex binding|positive regulation of fat cell differentiation|regulation of keratinocyte differentiation|negative regulation of erythrocyte differentiation|metal ion binding|mRNA transport|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|3'-UTR-mediated mRNA destabilization|RNA polymerase binding|RISC-loading complex|3'-UTR-mediated mRNA stabilization|cellular response to lipopolysaccharide|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|cellular response to glucocorticoid stimulus|14-3-3 protein binding|cellular response to granulocyte macrophage colony-stimulating factor stimulus|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA|regulation of keratinocyte apoptotic process|negative regulation of polynucleotide adenylyltransferase activity|positive regulation of intracellular mRNA localization|ribonucleoprotein complex|positive regulation of gene silencing by miRNA" "hsa05166,hsa05167" Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection ZFP36L1 4922.314315 4586.144395 5258.484235 1.146602414 0.197365222 0.410760088 1 76.6533346 86.42016335 677 ZFP36 ring finger protein like 1 "GO:0000165,GO:0000288,GO:0000932,GO:0001570,GO:0003342,GO:0003677,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006397,GO:0006915,GO:0007507,GO:0008283,GO:0009611,GO:0010468,GO:0010837,GO:0014065,GO:0021915,GO:0031086,GO:0031440,GO:0032869,GO:0033077,GO:0035264,GO:0035925,GO:0038066,GO:0043488,GO:0043491,GO:0044344,GO:0045577,GO:0045600,GO:0045616,GO:0045647,GO:0045657,GO:0045661,GO:0046872,GO:0048382,GO:0051028,GO:0060710,GO:0061158,GO:0070371,GO:0071320,GO:0071356,GO:0071364,GO:0071375,GO:0071385,GO:0071456,GO:0071472,GO:0071560,GO:0071889,GO:0072091,GO:0097403,GO:1900153,GO:1901991,GO:1902172,GO:1904582,GO:1990904" "MAPK cascade|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|P-body|vasculogenesis|proepicardium development|DNA binding|RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|cytosol|mRNA processing|apoptotic process|heart development|cell population proliferation|response to wounding|regulation of gene expression|regulation of keratinocyte proliferation|phosphatidylinositol 3-kinase signaling|neural tube development|nuclear-transcribed mRNA catabolic process, deadenylation-independent decay|regulation of mRNA 3'-end processing|cellular response to insulin stimulus|T cell differentiation in thymus|multicellular organism growth|mRNA 3'-UTR AU-rich region binding|p38MAPK cascade|regulation of mRNA stability|protein kinase B signaling|cellular response to fibroblast growth factor stimulus|regulation of B cell differentiation|positive regulation of fat cell differentiation|regulation of keratinocyte differentiation|negative regulation of erythrocyte differentiation|positive regulation of monocyte differentiation|regulation of myoblast differentiation|metal ion binding|mesendoderm development|mRNA transport|chorio-allantoic fusion|3'-UTR-mediated mRNA destabilization|ERK1 and ERK2 cascade|cellular response to cAMP|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|cellular response to peptide hormone stimulus|cellular response to glucocorticoid stimulus|cellular response to hypoxia|cellular response to salt stress|cellular response to transforming growth factor beta stimulus|14-3-3 protein binding|regulation of stem cell proliferation|cellular response to raffinose|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of mitotic cell cycle phase transition|regulation of keratinocyte apoptotic process|positive regulation of intracellular mRNA localization|ribonucleoprotein complex" hsa04218 Cellular senescence ZFP36L2 765.6992285 848.9777282 682.4207288 0.803814642 -0.315065237 0.21311774 1 12.26871947 9.696752877 678 ZFP36 ring finger protein like 2 "GO:0000288,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0006402,GO:0009611,GO:0030097,GO:0033077,GO:0035019,GO:0035925,GO:0043488,GO:0044344,GO:0045577,GO:0045599,GO:0046872,GO:0048103,GO:0060216,GO:0061158,GO:0070371,GO:0071356,GO:0071364,GO:0071385,GO:0071560,GO:0097011,GO:1900153,GO:1901991,GO:2000737" "nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|RNA binding|protein binding|nucleus|cytoplasm|mRNA catabolic process|response to wounding|hemopoiesis|T cell differentiation in thymus|somatic stem cell population maintenance|mRNA 3'-UTR AU-rich region binding|regulation of mRNA stability|cellular response to fibroblast growth factor stimulus|regulation of B cell differentiation|negative regulation of fat cell differentiation|metal ion binding|somatic stem cell division|definitive hemopoiesis|3'-UTR-mediated mRNA destabilization|ERK1 and ERK2 cascade|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|cellular response to glucocorticoid stimulus|cellular response to transforming growth factor beta stimulus|cellular response to granulocyte macrophage colony-stimulating factor stimulus|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of mitotic cell cycle phase transition|negative regulation of stem cell differentiation" hsa04218 Cellular senescence ZFP37 102.5260412 92.59683556 112.4552469 1.214461015 0.280316179 0.555855667 1 0.781670821 0.933423342 7539 ZFP37 zinc finger protein "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0003700,GO:0005634,GO:0006355,GO:0006357,GO:0008270" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding" hsa05168 Herpes simplex virus 1 infection ZFP41 364.4492569 370.3873422 358.5111716 0.967935809 -0.047016721 0.883282793 1 3.242068511 3.085602114 286128 ZFP41 zinc finger protein "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0007275,GO:0007283,GO:0030154,GO:0046872,GO:1990837" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|spermatogenesis|cell differentiation|metal ion binding|sequence-specific double-stranded DNA binding" ZFP62 415.3603401 445.2971418 385.4235384 0.865542359 -0.20832367 0.469616798 1 3.429248201 2.918491445 643836 ZFP62 zinc finger protein "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZFP64 860.3630293 873.9476614 846.7783972 0.968912024 -0.045562419 0.859507246 1 8.768749848 8.353975644 55734 ZFP64 zinc finger protein "GO:0003677,GO:0005515,GO:0005634,GO:0010468,GO:0045944,GO:0046872" DNA binding|protein binding|nucleus|regulation of gene expression|positive regulation of transcription by RNA polymerase II|metal ion binding zf-C2H2 ZFP69 134.1498386 127.9709076 140.3287696 1.096567745 0.132994944 0.767297465 1 2.36399174 2.548898846 339559 ZFP69 zinc finger protein "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0006629,GO:0019216,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|lipid metabolic process|regulation of lipid metabolic process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZFP69B 93.22648293 113.4051132 73.04785266 0.644131914 -0.634571921 0.1861375 1 2.595292651 1.643737007 65243 ZFP69 zinc finger protein B "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005730,GO:0006357,GO:0007030,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleolus|regulation of transcription by RNA polymerase II|Golgi organization|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZFP82 261.566555 268.4267817 254.7063283 0.948885676 -0.075693816 0.829033571 1 1.967780768 1.835953939 284406 ZFP82 zinc finger protein "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZFP90 879.7006193 788.633723 970.7675156 1.230948522 0.29977043 0.228751836 1 7.861025841 9.514594711 146198 ZFP90 zinc finger protein "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0043392,GO:0045893,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|negative regulation of DNA binding|positive regulation of transcription, DNA-templated|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZFP91 3333.674317 3416.719191 3250.629443 0.951389114 -0.071892577 0.762623818 1 31.56925615 29.5320575 80829 "ZFP91 zinc finger protein, atypical E3 ubiquitin ligase" "GO:0004842,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0007250,GO:0046872,GO:0070534" ubiquitin-protein transferase activity|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|activation of NF-kappaB-inducing kinase activity|metal ion binding|protein K63-linked ubiquitination ZFPL1 706.4107284 692.9156458 719.905811 1.038951589 0.055128431 0.834477695 1 26.7580568 27.33512482 7542 zinc finger protein like 1 "GO:0003677,GO:0005515,GO:0005634,GO:0005794,GO:0006355,GO:0008270,GO:0016021,GO:0016192" "DNA binding|protein binding|nucleus|Golgi apparatus|regulation of transcription, DNA-templated|zinc ion binding|integral component of membrane|vesicle-mediated transport" ZFPM1 105.969345 94.67766332 117.2610266 1.238528947 0.308627587 0.50948669 1 0.635808844 0.774290453 161882 "zinc finger protein, FOG family member 1" "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001085,GO:0001102,GO:0002295,GO:0003151,GO:0003181,GO:0003192,GO:0003195,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0007507,GO:0007596,GO:0008134,GO:0010724,GO:0017053,GO:0030154,GO:0030218,GO:0030219,GO:0030220,GO:0030851,GO:0032091,GO:0032642,GO:0032713,GO:0032729,GO:0035162,GO:0035855,GO:0045599,GO:0045652,GO:0045944,GO:0046872,GO:0055008,GO:0060318,GO:0060319,GO:0060377,GO:0060412,GO:0060413,GO:0071733" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|T-helper cell lineage commitment|outflow tract morphogenesis|atrioventricular valve morphogenesis|mitral valve formation|tricuspid valve formation|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|heart development|blood coagulation|transcription factor binding|regulation of definitive erythrocyte differentiation|transcription repressor complex|cell differentiation|erythrocyte differentiation|megakaryocyte differentiation|platelet formation|granulocyte differentiation|negative regulation of protein binding|regulation of chemokine production|negative regulation of interleukin-4 production|positive regulation of interferon-gamma production|embryonic hemopoiesis|megakaryocyte development|negative regulation of fat cell differentiation|regulation of megakaryocyte differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|cardiac muscle tissue morphogenesis|definitive erythrocyte differentiation|primitive erythrocyte differentiation|negative regulation of mast cell differentiation|ventricular septum morphogenesis|atrial septum morphogenesis|transcriptional activation by promoter-enhancer looping" ZFPM2 305.3683481 295.4775427 315.2591536 1.066947934 0.093489775 0.773816462 1 1.29467105 1.358231637 23414 "zinc finger protein, FOG family member 2" "GO:0000122,GO:0000785,GO:0001085,GO:0001570,GO:0001701,GO:0003148,GO:0003221,GO:0003677,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007506,GO:0007507,GO:0007596,GO:0008134,GO:0008270,GO:0030154,GO:0030324,GO:0045599,GO:0045892,GO:0045944,GO:0048568,GO:0060045,GO:0060412,GO:0060548,GO:2000020,GO:2000195" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription factor binding|vasculogenesis|in utero embryonic development|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|DNA binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|gonadal mesoderm development|heart development|blood coagulation|transcription factor binding|zinc ion binding|cell differentiation|lung development|negative regulation of fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|embryonic organ development|positive regulation of cardiac muscle cell proliferation|ventricular septum morphogenesis|negative regulation of cell death|positive regulation of male gonad development|negative regulation of female gonad development" hsa05206 MicroRNAs in cancer ZFR 2180.586422 2276.425575 2084.747269 0.915798562 -0.126897795 0.592279491 1 25.75549058 23.19214739 51663 zinc finger RNA binding protein "GO:0003677,GO:0003723,GO:0003725,GO:0003727,GO:0005515,GO:0005634,GO:0005694,GO:0005737,GO:0007275,GO:0008270" DNA binding|RNA binding|double-stranded RNA binding|single-stranded RNA binding|protein binding|nucleus|chromosome|cytoplasm|multicellular organism development|zinc ion binding ZFTA 546.5719905 609.6825352 483.4614459 0.792972437 -0.334657375 0.211791665 1 5.827984302 4.544097528 65998 zinc finger translocation associated ZFX 829.3185752 891.6346974 767.0024529 0.860220509 -0.217221568 0.386905215 1 4.419513796 3.738139161 7543 zinc finger protein X-linked "GO:0001541,GO:0005654,GO:0005694,GO:0005730,GO:0006357,GO:0007283,GO:0009566,GO:0009791,GO:0035264,GO:0043035,GO:0046872,GO:0048599,GO:0048872,GO:0060746" ovarian follicle development|nucleoplasm|chromosome|nucleolus|regulation of transcription by RNA polymerase II|spermatogenesis|fertilization|post-embryonic development|multicellular organism growth|chromatin insulator sequence binding|metal ion binding|oocyte development|homeostasis of number of cells|parental behavior zf-C2H2 ZFYVE1 645.1993021 637.7737101 652.6248941 1.023285977 0.033209391 0.904297367 1 7.054261291 7.09773439 53349 zinc finger FYVE-type containing 1 "GO:0000407,GO:0005515,GO:0005545,GO:0005547,GO:0005739,GO:0005776,GO:0005783,GO:0005789,GO:0005794,GO:0005795,GO:0005811,GO:0008270,GO:0009267,GO:0010923,GO:0016020,GO:0016236,GO:0032266,GO:0043325,GO:0044233,GO:0048471,GO:0097629,GO:0140042,GO:1990462" "phagophore assembly site|protein binding|1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|mitochondrion|autophagosome|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|Golgi stack|lipid droplet|zinc ion binding|cellular response to starvation|negative regulation of phosphatase activity|membrane|macroautophagy|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-3,4-bisphosphate binding|mitochondria-associated endoplasmic reticulum membrane|perinuclear region of cytoplasm|extrinsic component of omegasome membrane|lipid droplet formation|omegasome" "hsa04140,hsa05022" Autophagy - animal|Pathways of neurodegeneration - multiple diseases ZFYVE16 1361.641803 1480.508955 1242.774651 0.839423934 -0.252528497 0.292736933 1 7.702480198 6.357452395 9765 zinc finger FYVE-type containing 16 "GO:0005515,GO:0005545,GO:0005547,GO:0005769,GO:0005829,GO:0006622,GO:0007165,GO:0016050,GO:0016197,GO:0030100,GO:0030509,GO:0031901,GO:0043231,GO:0046872" "protein binding|1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|early endosome|cytosol|protein targeting to lysosome|signal transduction|vesicle organization|endosomal transport|regulation of endocytosis|BMP signaling pathway|early endosome membrane|intracellular membrane-bounded organelle|metal ion binding" "hsa04144,hsa04350" Endocytosis|TGF-beta signaling pathway ZFYVE19 478.182077 479.6307999 476.7333542 0.993959008 -0.00874174 0.983299891 1 10.35896976 10.12409514 84936 zinc finger FYVE-type containing 19 "GO:0005515,GO:0005737,GO:0005813,GO:0009838,GO:0030496,GO:0032154,GO:0032266,GO:0032466,GO:0044878,GO:0046872,GO:0051301,GO:0090543" protein binding|cytoplasm|centrosome|abscission|midbody|cleavage furrow|phosphatidylinositol-3-phosphate binding|negative regulation of cytokinesis|mitotic cytokinesis checkpoint|metal ion binding|cell division|Flemming body ZFYVE21 526.0763286 487.954111 564.1985462 1.15625329 0.209457471 0.440398676 1 18.12193047 20.60291258 79038 zinc finger FYVE-type containing 21 "GO:0005515,GO:0005768,GO:0005925,GO:0046872" protein binding|endosome|focal adhesion|metal ion binding ZFYVE26 1060.207398 1162.142307 958.2724881 0.824574136 -0.278278886 0.255331435 1 5.72893026 4.644879184 23503 zinc finger FYVE-type containing 26 "GO:0000281,GO:0000724,GO:0005515,GO:0005765,GO:0005813,GO:0030496,GO:0032266,GO:0032465,GO:0046872" mitotic cytokinesis|double-strand break repair via homologous recombination|protein binding|lysosomal membrane|centrosome|midbody|phosphatidylinositol-3-phosphate binding|regulation of cytokinesis|metal ion binding ZFYVE27 1795.369131 1764.541945 1826.196316 1.034940723 0.049548139 0.836557791 1 15.90446893 16.18474371 118813 zinc finger FYVE-type containing 27 "GO:0005515,GO:0005654,GO:0005783,GO:0005829,GO:0016192,GO:0030176,GO:0030424,GO:0030425,GO:0031175,GO:0032584,GO:0042802,GO:0043231,GO:0043621,GO:0045773,GO:0046872,GO:0048011,GO:0055038,GO:0071782,GO:0071787,GO:0072659" protein binding|nucleoplasm|endoplasmic reticulum|cytosol|vesicle-mediated transport|integral component of endoplasmic reticulum membrane|axon|dendrite|neuron projection development|growth cone membrane|identical protein binding|intracellular membrane-bounded organelle|protein self-association|positive regulation of axon extension|metal ion binding|neurotrophin TRK receptor signaling pathway|recycling endosome membrane|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network formation|protein localization to plasma membrane hsa04144 Endocytosis ZFYVE28 83.59038566 74.90979955 92.27097178 1.231761029 0.300722389 0.557960366 1 0.293588773 0.355579801 57732 zinc finger FYVE-type containing 28 "GO:0005515,GO:0005829,GO:0007175,GO:0031901,GO:0032266,GO:0042059,GO:0046872" protein binding|cytosol|negative regulation of epidermal growth factor-activated receptor activity|early endosome membrane|phosphatidylinositol-3-phosphate binding|negative regulation of epidermal growth factor receptor signaling pathway|metal ion binding ZFYVE9 1115.592752 1165.263549 1065.921955 0.914747532 -0.128554477 0.599432316 1 7.985101942 7.182123851 9372 zinc finger FYVE-type containing 9 "GO:0005515,GO:0005545,GO:0005769,GO:0005829,GO:0006897,GO:0007179,GO:0016197,GO:0019904,GO:0031901,GO:0032991,GO:0043231,GO:0046872" protein binding|1-phosphatidylinositol binding|early endosome|cytosol|endocytosis|transforming growth factor beta receptor signaling pathway|endosomal transport|protein domain specific binding|early endosome membrane|protein-containing complex|intracellular membrane-bounded organelle|metal ion binding "hsa04144,hsa04350" Endocytosis|TGF-beta signaling pathway ZGLP1 19.13380036 22.88910542 15.3784953 0.671869652 -0.573746729 0.533118397 1 0.616944186 0.407569878 100125288 zinc finger GATA like protein 1 "GO:0000122,GO:0005634,GO:0006357,GO:0007275,GO:0007283,GO:0008270,GO:0043565,GO:0045944,GO:0048599" negative regulation of transcription by RNA polymerase II|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|spermatogenesis|zinc ion binding|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|oocyte development ZGPAT 501.9882934 435.9334168 568.04317 1.303050301 0.381892777 0.162101365 1 11.37651112 14.5761039 84619 zinc finger CCCH-type and G-patch domain containing "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0006357,GO:0007175,GO:0043565,GO:0045892,GO:0046872" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|plasma membrane|regulation of transcription by RNA polymerase II|negative regulation of epidermal growth factor-activated receptor activity|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding" ZGRF1 518.1738448 520.2069413 516.1407484 0.992183509 -0.011321117 0.974642774 1 3.901966038 3.806682608 55345 zinc finger GRF-type containing 1 "GO:0003723,GO:0004386,GO:0005737,GO:0008270,GO:0016021,GO:0017108,GO:0071932" RNA binding|helicase activity|cytoplasm|zinc ion binding|integral component of membrane|5'-flap endonuclease activity|replication fork reversal ZHX1 792.4977388 833.37152 751.6239576 0.90190742 -0.148948745 0.556612123 1 8.905788216 7.897788544 11244 zinc fingers and homeoboxes 1 "GO:0000122,GO:0000785,GO:0000981,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0030154,GO:0045892,GO:0046872,GO:0046982" "negative regulation of transcription by RNA polymerase II|chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cell differentiation|negative regulation of transcription, DNA-templated|metal ion binding|protein heterodimerization activity" ZHX1-C8orf76 7.525701377 8.323311061 6.728091692 0.808343175 -0.306960188 0.918003413 1 0.335498349 0.266659673 100533106 ZHX1-C8orf76 readthrough GO:0005515 protein binding ZHX2 230.1509633 213.2848459 247.0170807 1.158155797 0.21182934 0.545154411 1 2.11730287 2.411132905 22882 zinc fingers and homeoboxes 2 "GO:0000122,GO:0000785,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006402,GO:0035019,GO:0042802,GO:0042803,GO:0045665,GO:0045892,GO:0046872,GO:0046982,GO:0060040" "negative regulation of transcription by RNA polymerase II|chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|mRNA catabolic process|somatic stem cell population maintenance|identical protein binding|protein homodimerization activity|negative regulation of neuron differentiation|negative regulation of transcription, DNA-templated|metal ion binding|protein heterodimerization activity|retinal bipolar neuron differentiation" ZHX3 3082.368476 3127.484131 3037.252821 0.971148915 -0.042235561 0.859669855 1 13.10727815 12.51611439 23051 zinc fingers and homeoboxes 3 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0030154,GO:0042803,GO:0045669,GO:0045892,GO:0046872,GO:0046982" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|cell differentiation|protein homodimerization activity|positive regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|metal ion binding|protein heterodimerization activity" ZIC2 459.132565 446.3375557 471.9275744 1.057333331 0.080430267 0.779652148 1 8.039222076 8.357899166 7546 Zic family member 2 "GO:0000978,GO:0000981,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007417,GO:0007420,GO:0007601,GO:0016604,GO:0030154,GO:0031490,GO:0045892,GO:0045893,GO:0046872,GO:0051091" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|central nervous system development|brain development|visual perception|nuclear body|cell differentiation|chromatin DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|positive regulation of DNA-binding transcription factor activity" ZIC5 59.16519713 64.50566072 53.82473354 0.834418762 -0.261156498 0.662031582 1 0.765521138 0.628076329 85416 Zic family member 5 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0007417,GO:0030154,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|central nervous system development|cell differentiation|metal ion binding|sequence-specific double-stranded DNA binding" ZIK1 179.3436758 178.9511878 179.7361638 1.004386537 0.006314595 1 1 1.666427499 1.645729616 284307 zinc finger protein interacting with K protein 1 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZKSCAN1 2498.507705 2825.764105 2171.251305 0.768376702 -0.380114319 0.107902308 1 14.08873662 10.64430762 7586 zinc finger with KRAB and SCAN domains 1 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZKSCAN2 270.7321352 281.9521622 259.5121081 0.920411839 -0.119648554 0.722149043 1 1.995658977 1.806091318 342357 zinc finger with KRAB and SCAN domains 2 "GO:0000978,GO:0000981,GO:0003674,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" ZKSCAN3 108.694297 90.51600779 126.8725862 1.401659102 0.487135514 0.286520781 1 0.873065782 1.203262959 80317 zinc finger with KRAB and SCAN domains 3 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0006914,GO:0007040,GO:0010507,GO:0043565,GO:0045892,GO:0045893,GO:0046872,GO:2000773" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|autophagy|lysosome organization|negative regulation of autophagy|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|negative regulation of cellular senescence" ZKSCAN4 104.4829517 106.122216 102.8436873 0.969106104 -0.045273465 0.943996967 1 0.892740798 0.850683266 387032 zinc finger with KRAB and SCAN domains 4 "GO:0000978,GO:0000981,GO:0005515,GO:0005654,GO:0006357,GO:0042802,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|identical protein binding|metal ion binding" ZKSCAN5 622.8895399 645.0566072 600.7224725 0.931270939 -0.102727136 0.698312135 1 6.914136486 6.331187533 23660 zinc finger with KRAB and SCAN domains 5 "GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding" ZKSCAN7 50.11850389 54.1015219 46.13548589 0.852757635 -0.229792327 0.725447661 1 0.727829289 0.610276046 55888 zinc finger with KRAB and SCAN domains 7 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZKSCAN8 1219.173684 1323.406459 1114.940909 0.842478062 -0.247288975 0.30676852 1 9.089803138 7.529814149 7745 zinc finger with KRAB and SCAN domains 8 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZMAT2 1276.962542 1225.607554 1328.317531 1.083803316 0.116102967 0.631765018 1 42.36296799 45.14483122 153527 zinc finger matrin-type 2 "GO:0000398,GO:0003677,GO:0005515,GO:0005634,GO:0008270,GO:0046540,GO:0071005" "mRNA splicing, via spliceosome|DNA binding|protein binding|nucleus|zinc ion binding|U4/U6 x U5 tri-snRNP complex|U2-type precatalytic spliceosome" hsa03040 Spliceosome ZMAT3 475.1155556 436.9738307 513.2572805 1.174572124 0.232135304 0.403412624 1 2.476161629 2.85976178 64393 zinc finger matrin-type 3 "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005886,GO:0006915,GO:0006974,GO:0008270,GO:0015031,GO:0040008" RNA binding|protein binding|nucleoplasm|nucleolus|plasma membrane|apoptotic process|cellular response to DNA damage stimulus|zinc ion binding|protein transport|regulation of growth hsa04115 p53 signaling pathway ZMAT5 310.6100465 306.9220954 314.2979976 1.024031839 0.034260571 0.923246387 1 15.45270578 15.55926845 55954 zinc finger matrin-type 5 "GO:0000398,GO:0005515,GO:0005654,GO:0005689,GO:0008270,GO:0008380" "mRNA splicing, via spliceosome|protein binding|nucleoplasm|U12-type spliceosomal complex|zinc ion binding|RNA splicing" ZMIZ1 1747.007549 2021.524174 1472.490925 0.72840629 -0.457184714 0.054089364 1 11.22049191 8.036311519 57178 zinc finger MIZ-type containing 1 "GO:0001570,GO:0001701,GO:0003007,GO:0003713,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0007179,GO:0007296,GO:0007569,GO:0008270,GO:0021852,GO:0030374,GO:0030521,GO:0033233,GO:0045582,GO:0045747,GO:0045944,GO:0046332,GO:0048096,GO:0048146,GO:0048589,GO:0048844,GO:0060395,GO:1903508" vasculogenesis|in utero embryonic development|heart morphogenesis|transcription coactivator activity|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|transforming growth factor beta receptor signaling pathway|vitellogenesis|cell aging|zinc ion binding|pyramidal neuron migration|nuclear receptor coactivator activity|androgen receptor signaling pathway|regulation of protein sumoylation|positive regulation of T cell differentiation|positive regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|SMAD binding|chromatin-mediated maintenance of transcription|positive regulation of fibroblast proliferation|developmental growth|artery morphogenesis|SMAD protein signal transduction|positive regulation of nucleic acid-templated transcription zf-MIZ ZMIZ2 1120.586001 1296.355698 944.8163047 0.728824895 -0.456355857 0.060834717 1 10.03977957 7.19479716 83637 zinc finger MIZ-type containing 2 "GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006357,GO:0007179,GO:0008270,GO:0030374,GO:0043596,GO:0045944,GO:0048096,GO:0060395" protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|transforming growth factor beta receptor signaling pathway|zinc ion binding|nuclear receptor coactivator activity|nuclear replication fork|positive regulation of transcription by RNA polymerase II|chromatin-mediated maintenance of transcription|SMAD protein signal transduction ZMPSTE24 1190.908902 1300.517353 1081.30045 0.831438695 -0.266318203 0.271812281 1 23.32982215 19.07272904 10269 zinc metallopeptidase STE24 "GO:0001889,GO:0001942,GO:0003007,GO:0003229,GO:0003231,GO:0003417,GO:0003690,GO:0004222,GO:0005515,GO:0005637,GO:0006281,GO:0006508,GO:0006925,GO:0006998,GO:0007628,GO:0008235,GO:0008340,GO:0008360,GO:0010506,GO:0010906,GO:0016020,GO:0019216,GO:0030176,GO:0030282,GO:0030327,GO:0030500,GO:0032006,GO:0032350,GO:0032991,GO:0035264,GO:0040014,GO:0043007,GO:0043516,GO:0043979,GO:0044029,GO:0044255,GO:0046872,GO:0048145,GO:0048538,GO:0048739,GO:0050688,GO:0050905,GO:0060307,GO:0060993,GO:0061337,GO:0061762,GO:0070062,GO:0070302,GO:0071480,GO:0071586,GO:0072423,GO:1903025,GO:1903463,GO:1903799,GO:1990036,GO:1990164,GO:2000618,GO:2000730,GO:2000772" "liver development|hair follicle development|heart morphogenesis|ventricular cardiac muscle tissue development|cardiac ventricle development|growth plate cartilage development|double-stranded DNA binding|metalloendopeptidase activity|protein binding|nuclear inner membrane|DNA repair|proteolysis|inflammatory cell apoptotic process|nuclear envelope organization|adult walking behavior|metalloexopeptidase activity|determination of adult lifespan|regulation of cell shape|regulation of autophagy|regulation of glucose metabolic process|membrane|regulation of lipid metabolic process|integral component of endoplasmic reticulum membrane|bone mineralization|prenylated protein catabolic process|regulation of bone mineralization|regulation of TOR signaling|regulation of hormone metabolic process|protein-containing complex|multicellular organism growth|regulation of multicellular organism growth|maintenance of rDNA|regulation of DNA damage response, signal transduction by p53 class mediator|histone H2B-K5 acetylation|hypomethylation of CpG island|cellular lipid metabolic process|metal ion binding|regulation of fibroblast proliferation|thymus development|cardiac muscle fiber development|regulation of defense response to virus|neuromuscular process|regulation of ventricular cardiac muscle cell membrane repolarization|kidney morphogenesis|cardiac conduction|CAMKK-AMPK signaling cascade|extracellular exosome|regulation of stress-activated protein kinase signaling cascade|cellular response to gamma radiation|CAAX-box protein processing|response to DNA damage checkpoint signaling|regulation of RNA polymerase II regulatory region sequence-specific DNA binding|regulation of mitotic cell cycle DNA replication|negative regulation of production of miRNAs involved in gene silencing by miRNA|calcium ion import into sarcoplasmic reticulum|histone H2A phosphorylation|regulation of histone H4-K16 acetylation|regulation of termination of RNA polymerase I transcription|regulation of cellular senescence" hsa00900 Terpenoid backbone biosynthesis ZMYM1 476.1358478 488.9945248 463.2771708 0.947407685 -0.07794272 0.784365584 1 4.93695404 4.59903978 79830 zinc finger MYM-type containing 1 "GO:0005634,GO:0008270,GO:0046983" nucleus|zinc ion binding|protein dimerization activity ZMYM2 1496.060212 1438.8924 1553.228025 1.079460858 0.110310932 0.64555583 1 5.374889256 5.704894249 7750 zinc finger MYM-type containing 2 "GO:0005515,GO:0005829,GO:0008150,GO:0008270,GO:0016605,GO:0031624" protein binding|cytosol|biological_process|zinc ion binding|PML body|ubiquitin conjugating enzyme binding ZMYM3 1749.971504 1821.764709 1678.178299 0.921182791 -0.118440635 0.618847459 1 16.174386 14.65024198 9203 zinc finger MYM-type containing 3 "GO:0003677,GO:0005515,GO:0005654,GO:0007010,GO:0007275,GO:0008270,GO:0022604" DNA binding|protein binding|nucleoplasm|cytoskeleton organization|multicellular organism development|zinc ion binding|regulation of cell morphogenesis other ZMYM4 1580.095349 1702.117112 1458.073585 0.85662354 -0.223266773 0.348680895 1 13.14219646 11.06952889 9202 zinc finger MYM-type containing 4 "GO:0003677,GO:0005515,GO:0007010,GO:0007275,GO:0008270,GO:0022604" DNA binding|protein binding|cytoskeleton organization|multicellular organism development|zinc ion binding|regulation of cell morphogenesis ZMYM5 259.8870473 262.1842984 257.5897962 0.982476059 -0.025505843 0.951135898 1 3.501575108 3.382646395 9205 zinc finger MYM-type containing 5 "GO:0000122,GO:0005515,GO:0005634,GO:0008270" negative regulation of transcription by RNA polymerase II|protein binding|nucleus|zinc ion binding ZMYM6 352.7719608 328.7707869 376.7731347 1.146005514 0.196613986 0.515807224 1 3.425594034 3.860057549 9204 zinc finger MYM-type containing 6 "GO:0003677,GO:0005634,GO:0007010,GO:0007275,GO:0008270,GO:0022604" DNA binding|nucleus|cytoskeleton organization|multicellular organism development|zinc ion binding|regulation of cell morphogenesis ZMYND10 13.33226608 9.363724944 17.30080721 1.847641543 0.88568489 0.401500149 1 0.281376571 0.511183504 51364 zinc finger MYND-type containing 10 "GO:0003341,GO:0005515,GO:0005737,GO:0006457,GO:0016324,GO:0034451,GO:0036158,GO:0036159,GO:0044183,GO:0044458,GO:0046872,GO:0060090,GO:0061512,GO:1905505" cilium movement|protein binding|cytoplasm|protein folding|apical plasma membrane|centriolar satellite|outer dynein arm assembly|inner dynein arm assembly|protein folding chaperone|motile cilium assembly|metal ion binding|molecular adaptor activity|protein localization to cilium|positive regulation of motile cilium assembly ZMYND11 906.1022256 863.5435226 948.6609286 1.098567592 0.135623638 0.586985645 1 8.539138535 9.223845529 10771 zinc finger MYND-type containing 11 "GO:0003690,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0006325,GO:0007049,GO:0008270,GO:0016032,GO:0034243,GO:0035064,GO:0043124,GO:0045892,GO:0046329,GO:0051607,GO:2001237" "double-stranded DNA binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|chromosome|chromatin organization|cell cycle|zinc ion binding|viral process|regulation of transcription elongation from RNA polymerase II promoter|methylated histone binding|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of transcription, DNA-templated|negative regulation of JNK cascade|defense response to virus|negative regulation of extrinsic apoptotic signaling pathway" ZMYND19 560.2118419 551.4193578 569.0043259 1.031890371 0.045289706 0.871623044 1 11.53596145 11.70465278 116225 zinc finger MYND-type containing 19 "GO:0005515,GO:0005737,GO:0005886,GO:0045202,GO:0046872" protein binding|cytoplasm|plasma membrane|synapse|metal ion binding ZMYND8 2680.955573 2556.29691 2805.614236 1.09753066 0.134261243 0.57080886 1 21.32304905 23.01108761 23613 zinc finger MYND-type containing 8 "GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0008270,GO:0019904,GO:0030336,GO:0035064,GO:0043197,GO:0043198,GO:0045892,GO:0047485,GO:0051491,GO:0060999,GO:0070491,GO:0070577,GO:0098815,GO:1902897,GO:1902952" "transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|zinc ion binding|protein domain specific binding|negative regulation of cell migration|methylated histone binding|dendritic spine|dendritic shaft|negative regulation of transcription, DNA-templated|protein N-terminus binding|positive regulation of filopodium assembly|positive regulation of dendritic spine development|repressing transcription factor binding|lysine-acetylated histone binding|modulation of excitatory postsynaptic potential|regulation of postsynaptic density protein 95 clustering|positive regulation of dendritic spine maintenance" ZNF10 124.8999701 124.8496659 124.9502743 1.000805836 0.001162108 1 1 1.51225538 1.488148072 7556 zinc finger protein 10 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0032991,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|protein-containing complex|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF100 205.6565777 175.8299462 235.4832092 1.339266799 0.421443393 0.242485088 1 1.648870333 2.171324763 163227 zinc finger protein 100 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF101 117.8548467 116.5263549 119.1833385 1.022801569 0.032526278 0.962554372 1 2.44834543 2.462267627 94039 zinc finger protein 101 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF106 1991.670815 2098.514801 1884.82683 0.898171806 -0.154936658 0.51328904 1 10.36308671 9.152078338 64397 zinc finger protein 106 "GO:0003723,GO:0005730,GO:0005829,GO:0008286,GO:0016020,GO:0016607,GO:0017124,GO:0046872" RNA binding|nucleolus|cytosol|insulin receptor signaling pathway|membrane|nuclear speck|SH3 domain binding|metal ion binding ZNF107 243.958777 235.1335375 252.7840164 1.075065765 0.104424917 0.767225916 1 1.927003185 2.03698881 51427 zinc finger protein 107 "GO:0000978,GO:0001228,GO:0003674,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|molecular_function|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF112 83.34758146 81.15228285 85.54288008 1.054103188 0.076016102 0.903442892 1 1.118530006 1.159316307 7771 zinc finger protein 112 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF114 133.4761462 110.2838716 156.6684208 1.420592319 0.50649259 0.232855306 1 1.998522082 2.791576874 163071 zinc finger protein 114 "GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0008150,GO:0042802,GO:0046872,GO:0070062" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|biological_process|identical protein binding|metal ion binding|extracellular exosome" hsa05168 Herpes simplex virus 1 infection ZNF12 1015.945763 984.231533 1047.659992 1.064444652 0.090100936 0.716451669 1 10.35007448 10.83272549 7559 zinc finger protein 12 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0006357,GO:0045892,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|centrosome|regulation of transcription by RNA polymerase II|negative regulation of transcription, DNA-templated|metal ion binding|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF121 502.1021499 451.5396251 552.6646747 1.223956092 0.291551803 0.286510975 1 3.32475716 4.001261604 7675 zinc finger protein 121 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF124 63.48536851 76.99062732 49.98010971 0.649171353 -0.623328757 0.258971995 1 0.766862314 0.489494618 7678 zinc finger protein 124 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF131 674.8360065 734.5322011 615.1398118 0.837457923 -0.255911388 0.321295792 1 9.393873367 7.735330532 7690 zinc finger protein 131 "GO:0000122,GO:0000978,GO:0001227,GO:0005654,GO:0006357,GO:0045111,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleoplasm|regulation of transcription by RNA polymerase II|intermediate filament cytoskeleton|metal ion binding" ZNF133 396.053547 354.781134 437.32596 1.23266408 0.301779696 0.299256078 1 4.312005707 5.22631096 7692 zinc finger protein 133 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF134 327.2717599 302.7604398 351.7830799 1.161918909 0.216509385 0.483603392 1 3.281431402 3.748955866 7693 zinc finger protein 134 "GO:0000122,GO:0000978,GO:0001227,GO:0005515,GO:0005654,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF136 128.9031098 129.0113214 128.7948981 0.998322447 -0.00242223 1 1 1.855321238 1.821214631 7695 zinc finger protein 136 "GO:0000122,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF138 149.3993861 149.8195991 148.9791732 0.994390414 -0.008115706 1 1 2.466254364 2.411381775 7697 zinc finger protein 138 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" ZNF14 81.10320743 85.31393838 76.89247648 0.901288558 -0.14993902 0.786271249 1 1.536634523 1.361775832 7561 zinc finger protein 14 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF140 272.9073121 250.7397457 295.0748785 1.176817332 0.234890399 0.47455087 1 3.370659796 3.900274336 7699 zinc finger protein 140 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0043565,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|metal ion binding|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF141 383.231427 371.4277561 395.0350979 1.063558367 0.08889921 0.768632136 1 1.800401152 1.882789595 7700 zinc finger protein 141 "GO:0000122,GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006366,GO:0009653,GO:0035108,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|transcription by RNA polymerase II|anatomical structure morphogenesis|limb morphogenesis|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF142 766.7497032 826.0886228 707.4107836 0.856337642 -0.223748351 0.377407839 1 2.917146266 2.456260468 7701 zinc finger protein 142 "GO:0000977,GO:0000981,GO:0003674,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" ZNF143 608.7697249 602.399638 615.1398118 1.02114904 0.030193447 0.914842775 1 6.973744364 7.00206818 7702 zinc finger protein 143 "GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005654,GO:0006355,GO:0006357,GO:0006359,GO:0042795,GO:0045944,GO:0045945,GO:0046872,GO:1905382" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|regulation of transcription by RNA polymerase III|snRNA transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase III|metal ion binding|positive regulation of snRNA transcription by RNA polymerase II" zf-C2H2 ZNF146 1904.499346 1866.502505 1942.496187 1.040714481 0.057574322 0.809763798 1 27.17921098 27.81247393 7705 zinc finger protein 146 "GO:0000978,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0005730,GO:0005829,GO:0006355,GO:0006357,GO:0008201,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleolus|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|heparin binding|zinc ion binding" zf-C2H2 ZNF148 1374.151307 1543.974202 1204.328413 0.780018482 -0.358419787 0.13492729 1 6.528209907 5.006914575 7707 zinc finger protein 148 "GO:0000122,GO:0000978,GO:0001227,GO:0003700,GO:0005515,GO:0005654,GO:0005794,GO:0006357,GO:0006968,GO:0007276,GO:0010629,GO:0021762,GO:0043565,GO:0045892,GO:0045944,GO:0046872,GO:0065003" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|Golgi apparatus|regulation of transcription by RNA polymerase II|cellular defense response|gamete generation|negative regulation of gene expression|substantia nigra development|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|protein-containing complex assembly" ZNF155 178.3428909 177.9107739 178.7750078 1.004857682 0.006991186 1 1 1.784060695 1.762728234 7711 zinc finger protein 155 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF157 9.685787068 14.56579436 4.80577978 0.32993599 -1.599741937 0.1811519 1 0.30896251 0.10023206 7712 zinc finger protein 157 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF16 211.8443408 224.7293987 198.9592829 0.88532824 -0.175715655 0.629053946 1 4.164373254 3.625143013 7564 zinc finger protein 16 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0007049,GO:0008284,GO:0033674,GO:0043066,GO:0045648,GO:0045654,GO:0046872,GO:0051301,GO:0051781,GO:0072707,GO:1901989" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|cell cycle|positive regulation of cell population proliferation|positive regulation of kinase activity|negative regulation of apoptotic process|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|metal ion binding|cell division|positive regulation of cell division|cellular response to sodium dodecyl sulfate|positive regulation of cell cycle phase transition" ZNF160 433.9789639 454.6608667 413.2970611 0.909022727 -0.13761173 0.631580482 1 3.697716371 3.305061279 90338 zinc finger protein 160 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0030097,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|hemopoiesis|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF165 39.63007672 43.69738307 35.56277037 0.813842108 -0.297179167 0.673939417 1 1.087202341 0.870004931 7718 zinc finger protein 165 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF169 127.8972944 140.4558742 115.3387147 0.821174019 -0.284240111 0.515412827 1 1.449878502 1.170679436 169841 zinc finger protein 169 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF17 95.79794951 92.59683556 98.99906347 1.069140893 0.096451986 0.860125231 1 1.820826429 1.914144272 7565 zinc finger protein 17 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF174 177.5849102 170.6278768 184.5419436 1.081546269 0.113095386 0.778634043 1 3.510445714 3.733176674 7727 zinc finger protein 174 "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006357,GO:0015629,GO:0042803,GO:0043565,GO:0045892,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|actin cytoskeleton|protein homodimerization activity|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding|sequence-specific double-stranded DNA binding" ZNF175 243.3196831 230.9718819 255.6674843 1.106920384 0.146551459 0.67294669 1 3.241268691 3.527788969 7728 zinc finger protein 175 "GO:0000122,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0045111,GO:0045944,GO:0046872,GO:0051607" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|intermediate filament cytoskeleton|positive regulation of transcription by RNA polymerase II|metal ion binding|defense response to virus" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF18 116.6112576 121.7284243 111.4940909 0.915924868 -0.126698834 0.791378955 1 0.937569963 0.844373733 7566 zinc finger protein 18 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF180 131.1820824 138.3750464 123.9891183 0.896036688 -0.15837029 0.723020233 1 1.611702729 1.419978969 7733 zinc finger protein 180 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF181 74.41977512 73.86938567 74.97016457 1.014901693 0.021339989 0.997054433 1 0.55815848 0.556996778 339318 zinc finger protein 181 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF182 424.3328058 441.1354862 407.5301253 0.923820772 -0.11431511 0.693711147 1 6.543243504 5.943632985 7569 zinc finger protein 182 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF184 205.2797954 216.4060876 194.1535031 0.897172096 -0.156543345 0.672473576 1 3.400823073 3.000067143 7738 zinc finger protein 184 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF185 5963.44509 5285.302524 6641.587656 1.256614475 0.329542104 0.173619192 1 54.52675077 67.37252987 7739 zinc finger protein 185 with LIM domain "GO:0005515,GO:0005737,GO:0005925,GO:0008270,GO:0015629,GO:0051015" protein binding|cytoplasm|focal adhesion|zinc ion binding|actin cytoskeleton|actin filament binding ZNF189 320.9695259 339.1749257 302.7641261 0.892648905 -0.163835246 0.600479294 1 2.516144344 2.208449165 7743 zinc finger protein 189 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF19 44.14839292 61.38441908 26.91236677 0.438423417 -1.189603237 0.058768293 1 1.021825835 0.440495828 7567 zinc finger protein 19 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF195 287.7108802 286.1138177 289.3079428 1.011163827 0.016016758 0.972246314 1 4.567564642 4.541270859 7748 zinc finger protein 195 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding" hsa05168 Herpes simplex virus 1 infection ZNF2 114.5304298 117.5667687 111.4940909 0.948346987 -0.076513077 0.883098604 1 1.733717151 1.616652554 7549 zinc finger protein 2 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding" hsa05168 Herpes simplex virus 1 infection ZNF20 142.1510875 148.7791852 135.5229898 0.910900202 -0.134635094 0.758317075 1 2.643166335 2.367371805 7568 zinc finger protein 20 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF200 181.9447105 184.1532572 179.7361638 0.976014036 -0.0350262 0.941568333 1 2.598604146 2.493833007 7752 zinc finger protein 200 "GO:0003674,GO:0005515,GO:0005634,GO:0008150,GO:0046872" molecular_function|protein binding|nucleus|biological_process|metal ion binding hsa05168 Herpes simplex virus 1 infection ZNF202 252.9161514 268.4267817 237.4055211 0.884433064 -0.177175134 0.601889042 1 2.953699792 2.568635623 7753 zinc finger protein 202 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005694,GO:0005730,GO:0006357,GO:0006629,GO:0016604,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|chromosome|nucleolus|regulation of transcription by RNA polymerase II|lipid metabolic process|nuclear body|metal ion binding" ZNF205 182.4894551 223.6889848 141.2899255 0.631635597 -0.662835615 0.078011349 1 5.446108574 3.382393037 7755 zinc finger protein 205 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005739,GO:0006355,GO:0006357,GO:0008270,GO:0010729,GO:1901030" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|mitochondrion|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding|positive regulation of hydrogen peroxide biosynthetic process|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway" hsa05168 Herpes simplex virus 1 infection ZNF207 4782.663039 4793.186757 4772.139322 0.995608885 -0.00634899 0.979826425 1 18.61743579 18.2255149 7756 zinc finger protein 207 "GO:0000070,GO:0000776,GO:0000777,GO:0001578,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005819,GO:0005874,GO:0007094,GO:0008017,GO:0008608,GO:0046785,GO:0046872,GO:0050821,GO:0051301,GO:0051983,GO:0090307,GO:1990047" mitotic sister chromatid segregation|kinetochore|condensed chromosome kinetochore|microtubule bundle formation|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|spindle|microtubule|mitotic spindle assembly checkpoint|microtubule binding|attachment of spindle microtubules to kinetochore|microtubule polymerization|metal ion binding|protein stabilization|cell division|regulation of chromosome segregation|mitotic spindle assembly|spindle matrix ZNF208 9.408384325 7.282897178 11.53387147 1.583692752 0.663292469 0.627344635 1 0.034432569 0.053618114 7757 zinc finger protein 208 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0008270,GO:0045944" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding|positive regulation of transcription by RNA polymerase II" hsa05168 Herpes simplex virus 1 infection ZNF211 194.6328523 201.8402932 187.4254114 0.928582734 -0.106897638 0.782643563 1 2.790633545 2.547971661 10520 zinc finger protein 211 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF212 347.7233769 335.0132702 360.4334835 1.075878228 0.105514797 0.733195299 1 6.369448701 6.738079671 7988 zinc finger protein 212 "GO:0000978,GO:0003700,GO:0005515,GO:0005654,GO:0006355,GO:0006357,GO:0008270,GO:0042802" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding|identical protein binding" hsa05168 Herpes simplex virus 1 infection ZNF213 166.4026689 192.4765683 140.3287696 0.729069366 -0.455872012 0.243342671 1 3.053543607 2.188991904 7760 zinc finger protein 213 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF214 69.49510845 70.74814402 68.24207288 0.96457757 -0.052030832 0.951339537 1 0.441189345 0.418440154 7761 zinc finger protein 214 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF215 190.421507 217.4465015 163.3965125 0.751433164 -0.412283306 0.266700293 1 4.458209809 3.293988206 7762 zinc finger protein 215 "GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF217 2310.91053 2556.29691 2065.524149 0.808014179 -0.307547485 0.193223163 1 15.6756139 12.45416797 7764 zinc finger protein 217 "GO:0000118,GO:0000122,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006355,GO:0016607,GO:0045892,GO:0046872" "histone deacetylase complex|negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription, DNA-templated|nuclear speck|negative regulation of transcription, DNA-templated|metal ion binding" zf-C2H2 ZNF219 223.8587902 224.7293987 222.9881818 0.99225194 -0.011221617 0.988871415 1 3.353857654 3.272184337 51222 zinc finger protein 219 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0001505,GO:0003677,GO:0003700,GO:0004969,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0007186,GO:0016021,GO:0032332,GO:0045892,GO:0045944,GO:0046872,GO:0060174" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|regulation of neurotransmitter levels|DNA binding|DNA-binding transcription factor activity|histamine receptor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|G protein-coupled receptor signaling pathway|integral component of membrane|positive regulation of chondrocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|limb bud formation" ZNF22 767.0623189 745.9767539 788.1478839 1.056531427 0.079335681 0.757896522 1 18.93076952 19.66626407 7570 zinc finger protein 22 "GO:0000977,GO:0000981,GO:0003677,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0008270,GO:0042476" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding|odontogenesis" zf-C2H2 ZNF221 40.9132948 39.53572754 42.29086206 1.069687209 0.097188995 0.919794412 1 0.698196266 0.734354065 7638 zinc finger protein 221 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF222 80.02316458 82.19269673 77.85363244 0.947208639 -0.078245855 0.902052213 1 1.898084449 1.767796868 7673 zinc finger protein 222 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF223 108.5653493 112.3646993 104.7659992 0.932374668 -0.101018287 0.842831073 1 0.86607416 0.793993095 7766 zinc finger protein 223 "GO:0000978,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF224 405.3971503 423.4484502 387.3458503 0.914741452 -0.128564066 0.660941433 1 3.885602738 3.494845128 7767 zinc finger protein 224 "GO:0000122,GO:0000978,GO:0001227,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0017053,GO:0031965,GO:0043565,GO:0045892,GO:0045944,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription repressor complex|nuclear membrane|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF225 118.7763737 115.485941 122.0668064 1.056984126 0.079953711 0.874740124 1 1.102158873 1.145470331 7768 zinc finger protein 225 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF226 331.3591879 296.5179566 366.2004192 1.235002505 0.304513969 0.320111234 1 4.400616898 5.34382933 7769 zinc finger protein 226 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF227 267.4127487 270.5076095 264.3178879 0.977118124 -0.033395115 0.930851446 1 4.282555309 4.114539424 7770 zinc finger protein 227 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF23 235.0705996 228.8910542 241.250145 1.053995517 0.075868731 0.836110186 1 3.398857785 3.522434575 7571 zinc finger protein 23 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection ZNF230 105.8850566 105.0818021 106.6883111 1.015288175 0.021889274 0.985347629 1 1.366477254 1.364152469 7773 zinc finger protein 230 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF232 176.2123733 197.6786377 154.7461089 0.782816549 -0.35325384 0.357229558 1 2.817021516 2.16830984 7775 zinc finger protein 232 "GO:0000978,GO:0000981,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0043231,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|intracellular membrane-bounded organelle|metal ion binding" ZNF233 15.93330078 14.56579436 17.30080721 1.187769564 0.248254969 0.853385722 1 0.19375615 0.226286616 353355 zinc finger protein 233 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF234 152.4759684 167.5066351 137.4453017 0.820536462 -0.285360651 0.484903318 1 2.291597347 1.84887425 10780 zinc finger protein 234 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF235 56.16284237 61.38441908 50.94126567 0.829872897 -0.269037705 0.658865786 1 1.02695098 0.837977723 9310 zinc finger protein 235 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF236 537.7630711 605.5208797 470.0052625 0.776199927 -0.365499798 0.173982139 1 3.496973969 2.668929952 7776 zinc finger protein 236 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:0071333" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|cellular response to glucose stimulus" zf-C2H2 ZNF239 119.6482109 138.3750464 100.9213754 0.729332188 -0.455352028 0.30238611 1 1.521388938 1.091030304 8187 zinc finger protein 239 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|RNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF24 2384.221922 2399.194413 2369.249432 0.987518735 -0.018119976 0.94075631 1 20.46684724 19.87318476 7572 zinc finger protein 24 "GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0042552,GO:0042802,GO:0043565,GO:0045892,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|myelination|identical protein binding|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF248 332.0328803 314.2049926 349.860768 1.113479341 0.155074791 0.617003273 1 1.467320876 1.606491524 57209 zinc finger protein 248 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF25 167.8198652 153.9812546 181.6584757 1.179744094 0.238473949 0.546927946 1 1.64881552 1.912630413 219749 zinc finger protein 25 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF250 254.5365229 222.6485709 286.4244749 1.286442009 0.363386424 0.276522876 1 1.384888697 1.751766686 58500 zinc finger protein 250 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF251 388.3988979 368.3065145 408.4912813 1.109106859 0.149398371 0.613478781 1 3.857868844 4.207189059 90987 zinc finger protein 251 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF253 82.42605447 82.19269673 82.65941222 1.005678308 0.008168897 1 1 1.220498932 1.206889934 56242 zinc finger protein 253 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0045892,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|negative regulation of transcription, DNA-templated|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF254 291.7687401 253.8609874 329.6764929 1.298649691 0.377012319 0.235734968 1 2.388171042 3.049499898 9534 zinc finger protein 254 "GO:0000122,GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF256 64.97679225 53.06110801 76.89247648 1.449130622 0.535187643 0.33146742 1 1.283087364 1.828247299 10172 zinc finger protein 256 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0045892,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|negative regulation of transcription, DNA-templated|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF257 51.80304202 47.8590386 55.74704545 1.164817495 0.220103929 0.734695048 1 0.62832692 0.719639064 113835 zinc finger protein 257 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF26 266.8579432 255.9418151 277.7740713 1.085301638 0.118096067 0.72728785 1 0.703209652 0.750423559 7574 zinc finger protein 26 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF260 415.0980286 400.5593448 429.6367123 1.072591909 0.101101276 0.730429425 1 3.402915638 3.588862981 339324 zinc finger protein 260 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0007275,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|multicellular organism development|metal ion binding" zf-C2H2 ZNF263 611.4896465 610.7229491 612.256344 1.002510786 0.003617759 0.996166863 1 7.444760469 7.338561899 10127 zinc finger protein 263 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0043565,GO:0045944,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 ZNF264 259.5303866 252.8205735 266.2401998 1.053079645 0.074614553 0.832253513 1 2.208999565 2.287325793 9422 zinc finger protein 264 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF266 801.1336655 769.9062732 832.3610579 1.081119984 0.112526644 0.657812402 1 10.33152697 10.98271181 10781 zinc finger protein 266 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF267 537.1843423 451.5396251 622.8290595 1.3793453 0.463983661 0.084507059 1 7.048212897 9.559236177 10308 zinc finger protein 267 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0007275,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF268 397.7079026 423.4484502 371.967355 0.878424174 -0.187010338 0.522138442 1 1.680948046 1.451876741 10795 zinc finger protein 268 "GO:0000122,GO:0000978,GO:0001228,GO:0003677,GO:0003700,GO:0005634,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0007346,GO:0008284,GO:0008285,GO:0015629,GO:0030154,GO:0030335,GO:0043065,GO:0043066,GO:0045597,GO:0045944,GO:0046872,GO:0071157" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleus|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|regulation of mitotic cell cycle|positive regulation of cell population proliferation|negative regulation of cell population proliferation|actin cytoskeleton|cell differentiation|positive regulation of cell migration|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|negative regulation of cell cycle arrest" hsa05168 Herpes simplex virus 1 infection ZNF273 133.1490537 126.9304937 139.3676136 1.097983704 0.134856643 0.764583051 1 0.618182803 0.667396605 10793 zinc finger protein 273 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF274 236.6658189 245.5376763 227.7939616 0.927735267 -0.10821491 0.76123393 1 3.632906711 3.313977003 10782 zinc finger protein 274 "GO:0000122,GO:0000978,GO:0000981,GO:0003682,GO:0005515,GO:0005730,GO:0005737,GO:0006355,GO:0006357,GO:0043565,GO:0046872,GO:1900112,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|chromatin binding|protein binding|nucleolus|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|metal ion binding|regulation of histone H3-K9 trimethylation|sequence-specific double-stranded DNA binding" hsa04722 Neurotrophin signaling pathway ZNF275 635.5726513 675.2286098 595.9166927 0.882540645 -0.180265373 0.4906494 1 5.700049018 4.946345913 10838 zinc finger protein 275 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF276 236.5815306 255.9418151 217.2212461 0.848713392 -0.236650653 0.493011042 1 2.159889986 1.802452649 92822 zinc finger protein 276 "GO:0000776,GO:0000777,GO:0005515,GO:0005634,GO:0005694,GO:0006357,GO:0008270,GO:0043035,GO:1990837" kinetochore|condensed chromosome kinetochore|protein binding|nucleus|chromosome|regulation of transcription by RNA polymerase II|zinc ion binding|chromatin insulator sequence binding|sequence-specific double-stranded DNA binding ZNF277 973.417741 877.0689031 1069.766579 1.219706428 0.286533946 0.245222271 1 23.35706356 28.01203974 11179 zinc finger protein 277 "GO:0000978,GO:0005634,GO:0046872,GO:0070301,GO:2000772" RNA polymerase II cis-regulatory region sequence-specific DNA binding|nucleus|metal ion binding|cellular response to hydrogen peroxide|regulation of cellular senescence ZNF28 314.2068357 325.6495453 302.7641261 0.92972378 -0.105125938 0.742588684 1 2.106583965 1.925767672 7576 zinc finger protein 28 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF280C 546.9531889 657.5415738 436.364804 0.663630744 -0.591547371 0.027209764 0.873458973 7.56614603 4.937105358 55609 zinc finger protein 280C "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" ZNF280D 506.4317677 539.9748051 472.8887303 0.875760732 -0.191391333 0.485037489 1 2.846169177 2.450853531 54816 zinc finger protein 280D "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF281 1579.832423 1758.299462 1401.365384 0.797000405 -0.327347637 0.16914704 1 19.29218969 15.11858843 23528 zinc finger protein 281 "GO:0000122,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0010172,GO:0010629,GO:0043565,GO:0045892,GO:0045893,GO:0046872,GO:0048863,GO:1990837" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|embryonic body morphogenesis|negative regulation of gene expression|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|stem cell differentiation|sequence-specific double-stranded DNA binding" zf-C2H2 ZNF282 717.3099221 777.1891703 657.4306739 0.845908177 -0.241427028 0.345117165 1 11.17982685 9.298855066 8427 zinc finger protein 282 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006355,GO:0006357,GO:0008270,GO:0045892,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding|negative regulation of transcription, DNA-templated|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection ZNF283 330.1898263 316.2858203 344.0938322 1.087920514 0.121573154 0.697800746 1 1.004976954 1.075039563 284349 zinc finger protein 283 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF284 93.07802791 84.27352449 101.8825313 1.20895064 0.273755342 0.580029987 1 1.791128281 2.129150884 342909 zinc finger protein 284 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF285 12.049048 13.52538047 10.57271552 0.781694499 -0.355323209 0.80166462 1 0.114995172 0.088386888 26974 zinc finger protein 285 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF286A 260.8777714 288.1946455 233.5608973 0.810427608 -0.303244772 0.360585916 1 2.832489604 2.257115227 57335 zinc finger protein 286A "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF292 913.0624463 983.1911191 842.9337734 0.85734478 -0.222052597 0.371272854 1 2.571734696 2.167967915 23036 zinc finger protein 292 "GO:0000981,GO:0001228,GO:0003677,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF296 33.10516026 36.41448589 29.79583464 0.818241255 -0.289401816 0.70895072 1 1.189335487 0.95687879 162979 zinc finger protein 296 "GO:0000122,GO:0000978,GO:0003700,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0007283,GO:0008134,GO:0045944,GO:0046872,GO:1990837" negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|spermatogenesis|transcription factor binding|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding ZNF3 580.1382215 595.1167409 565.1597021 0.949661912 -0.074514102 0.783729702 1 7.590890698 7.088150609 7551 zinc finger protein 3 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0007275,GO:0008270,GO:0030154,GO:0042802,GO:0045321" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|zinc ion binding|cell differentiation|identical protein binding|leukocyte activation" hsa05168 Herpes simplex virus 1 infection ZNF30 73.89956818 72.82897178 74.97016457 1.029400289 0.041804092 0.964815899 1 0.995326087 1.007443853 90075 zinc finger protein 30 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF302 352.9204158 357.9023756 347.9384561 0.972160231 -0.040733978 0.901453147 1 5.28224336 5.049256525 55900 zinc finger protein 302 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF304 211.9632277 227.8506403 196.075815 0.860545376 -0.216676828 0.548369412 1 2.607756788 2.206541188 57343 zinc finger protein 304 "GO:0000978,GO:0000981,GO:0001525,GO:0005515,GO:0005634,GO:0006325,GO:0006357,GO:0007229,GO:0007265,GO:0030335,GO:0035562,GO:0045766,GO:0045944,GO:0046872,GO:0050679,GO:0090309,GO:1900114,GO:1902466,GO:1990841,GO:2000811" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|angiogenesis|protein binding|nucleus|chromatin organization|regulation of transcription by RNA polymerase II|integrin-mediated signaling pathway|Ras protein signal transduction|positive regulation of cell migration|negative regulation of chromatin binding|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of epithelial cell proliferation|positive regulation of DNA methylation-dependent heterochromatin assembly|positive regulation of histone H3-K9 trimethylation|positive regulation of histone H3-K27 trimethylation|promoter-specific chromatin binding|negative regulation of anoikis" hsa05168 Herpes simplex virus 1 infection ZNF311 85.14597607 90.51600779 79.77594435 0.881346254 -0.182219174 0.730427304 1 1.244056908 1.078097375 282890 zinc finger protein 311 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF316 579.102838 580.5509465 577.6547296 0.995011261 -0.007215241 0.985643684 1 5.493428548 5.374556771 100131017 zinc finger protein 316 "GO:0000981,GO:0005634,GO:0006357,GO:0043565,GO:0046872" "DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF317 551.8438714 546.2172884 557.4704545 1.020601995 0.029420368 0.919477569 1 6.799769717 6.823729407 57693 zinc finger protein 317 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF318 835.0609732 853.1393838 816.9825626 0.957619093 -0.062476178 0.807053295 1 5.545734581 5.221833923 24149 zinc finger protein 318 "GO:0003676,GO:0005654,GO:0005829,GO:0008270,GO:0042803,GO:0045892,GO:0045893,GO:0051321" "nucleic acid binding|nucleoplasm|cytosol|zinc ion binding|protein homodimerization activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|meiotic cell cycle" ZNF319 314.7169818 351.6598923 277.7740713 0.789894092 -0.340268864 0.273231795 1 3.733328452 2.899587669 57567 zinc finger protein 319 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF32 287.948654 292.356301 283.541007 0.969847429 -0.044170286 0.901208494 1 10.5422422 10.05327557 7580 zinc finger protein 32 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZNF320 634.2598651 653.3799183 615.1398118 0.941473398 -0.087007764 0.742835136 1 3.243691663 3.002747378 162967 zinc finger protein 320 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF322 306.0175028 274.669265 337.3657406 1.228261708 0.296617991 0.34490576 1 3.000121542 3.623272022 79692 zinc finger protein 322 "GO:0000978,GO:0000981,GO:0005654,GO:0005813,GO:0005829,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleoplasm|centrosome|cytosol|regulation of transcription by RNA polymerase II|metal ion binding" other ZNF324 76.0200249 78.0310412 74.00900861 0.948455992 -0.07634726 0.908224956 1 1.046062108 0.975541691 25799 zinc finger protein 324 "GO:0000082,GO:0000978,GO:0000981,GO:0003674,GO:0005575,GO:0005634,GO:0006357,GO:0008283,GO:0046872" "G1/S transition of mitotic cell cycle|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|cellular_component|nucleus|regulation of transcription by RNA polymerase II|cell population proliferation|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF324B 38.55003388 40.57614142 36.52392633 0.90013306 -0.151789815 0.854693464 1 0.696741986 0.616665814 388569 zinc finger protein 324B "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF326 524.9214438 571.1872216 478.6556661 0.838001356 -0.254975517 0.346659131 1 3.911112679 3.222672907 284695 zinc finger protein 326 "GO:0000993,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0006397,GO:0008380,GO:0016363,GO:0032784,GO:0043231,GO:0043484,GO:0044609,GO:0046872" "RNA polymerase II complex binding|DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|mRNA processing|RNA splicing|nuclear matrix|regulation of DNA-templated transcription, elongation|intracellular membrane-bounded organelle|regulation of RNA splicing|DBIRD complex|metal ion binding" ZNF329 154.1309384 135.2538047 173.0080721 1.279136453 0.355170173 0.380335259 1 1.619893845 2.037392061 79673 zinc finger protein 329 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF330 1045.890052 1013.363122 1078.416983 1.064196002 0.089763889 0.716702753 1 23.92979085 25.03984893 27309 zinc finger protein 330 "GO:0000775,GO:0005515,GO:0005634,GO:0005730,GO:0008150,GO:0008270,GO:0030496,GO:0046872" "chromosome, centromeric region|protein binding|nucleus|nucleolus|biological_process|zinc ion binding|midbody|metal ion binding" ZNF331 563.9916846 612.8037769 515.1795924 0.840692587 -0.250349743 0.34803864 1 3.612527481 2.986204571 55422 zinc finger protein 331 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF333 76.33202619 98.83931885 53.82473354 0.544568034 -0.876815796 0.088357564 1 0.444050239 0.23776911 84449 zinc finger protein 333 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF335 764.222896 835.4523478 692.9934443 0.82948291 -0.269715838 0.286959756 1 9.000112294 7.340515315 63925 zinc finger protein 335 "GO:0000976,GO:0000978,GO:0001701,GO:0002052,GO:0005515,GO:0005634,GO:0005654,GO:0007420,GO:0010468,GO:0021895,GO:0035097,GO:0040029,GO:0045944,GO:0046872,GO:0048812,GO:0048854,GO:0050671,GO:0050769,GO:0051569,GO:0080182" "transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|in utero embryonic development|positive regulation of neuroblast proliferation|protein binding|nucleus|nucleoplasm|brain development|regulation of gene expression|cerebral cortex neuron differentiation|histone methyltransferase complex|regulation of gene expression, epigenetic|positive regulation of transcription by RNA polymerase II|metal ion binding|neuron projection morphogenesis|brain morphogenesis|positive regulation of lymphocyte proliferation|positive regulation of neurogenesis|regulation of histone H3-K4 methylation|histone H3-K4 trimethylation" zf-C2H2 ZNF337 999.3979056 1003.999397 994.7964145 0.990833677 -0.01328519 0.961364161 1 5.652067778 5.50654635 26152 zinc finger protein 337 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF33A 543.475901 541.015219 545.936583 1.009096535 0.013064197 0.96880356 1 4.385326229 4.351167482 7581 zinc finger protein 33A "GO:0000978,GO:0001228,GO:0003700,GO:0005634,GO:0006355,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF33B 519.8036628 550.3789439 489.2283816 0.88889371 -0.169917176 0.533560315 1 4.77993697 4.17775706 7582 zinc finger protein 33B "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF34 126.7379937 135.2538047 118.2221826 0.874076576 -0.194168418 0.6638989 1 1.622807323 1.394721898 80778 zinc finger protein 34 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF341 145.0395858 136.2942186 153.784953 1.128330714 0.174189983 0.683002579 1 2.175821702 2.413964576 84905 zinc finger protein 341 "GO:0000978,GO:0000981,GO:0001216,GO:0003677,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0045893,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity|DNA binding|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|positive regulation of transcription, DNA-templated|metal ion binding" zf-C2H2 ZNF343 481.2636897 484.8328693 477.6945101 0.98527666 -0.021399213 0.946274065 1 6.415730015 6.215491164 79175 zinc finger protein 343 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection ZNF345 68.21692079 62.42483296 74.00900861 1.18556999 0.245580835 0.664476762 1 0.845558021 0.985693267 25850 zinc finger protein 345 "GO:0000122,GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0006359,GO:0006366,GO:0006383,GO:0045944,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|regulation of transcription by RNA polymerase III|transcription by RNA polymerase II|transcription by RNA polymerase III|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZNF346 245.8313991 259.0630568 232.5997414 0.897849907 -0.155453805 0.652103461 1 1.850089549 1.633306425 23567 zinc finger protein 346 "GO:0003723,GO:0003725,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0008270,GO:0019899,GO:0035198" RNA binding|double-stranded RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|zinc ion binding|enzyme binding|miRNA binding ZNF347 339.9844394 358.9427895 321.0260893 0.894365617 -0.161063369 0.600190415 1 2.303525369 2.025719332 84671 zinc finger protein 347 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF35 144.801812 130.0517353 159.5518887 1.226833985 0.294940037 0.479277714 1 2.611219748 3.14992634 7584 zinc finger protein 35 "GO:0000977,GO:0000981,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0007283,GO:0043565,GO:0046872,GO:0048471,GO:0071300" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|spermatogenesis|sequence-specific DNA binding|metal ion binding|perinuclear region of cytoplasm|cellular response to retinoic acid" zf-C2H2 ZNF350 154.7700322 139.4154603 170.1246042 1.220270721 0.28720125 0.479855623 1 1.796751239 2.155834028 59348 zinc finger protein 350 "GO:0000122,GO:0000978,GO:0001162,GO:0001227,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0016363,GO:0016604,GO:0017053,GO:0045892,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|nuclear matrix|nuclear body|transcription repressor complex|negative regulation of transcription, DNA-templated|metal ion binding" hsa05168 Herpes simplex virus 1 infection other ZNF354A 313.0028755 331.8920286 294.1137225 0.886172903 -0.174339881 0.579774691 1 5.533416924 4.821509635 6940 zinc finger protein 354A "GO:0000122,GO:0000978,GO:0000981,GO:0001666,GO:0001822,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0007576,GO:0007605,GO:0046872,GO:0051593" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|response to hypoxia|kidney development|nucleus|nucleoplasm|nucleolus|cytosol|regulation of transcription by RNA polymerase II|nucleolar fragmentation|sensory perception of sound|metal ion binding|response to folic acid" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF354B 212.4588969 190.3957405 234.5220533 1.231761029 0.300722389 0.400860213 1 3.636746864 4.404642969 117608 zinc finger protein 354B "GO:0000122,GO:0000978,GO:0000981,GO:0003682,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|chromatin binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF358 495.2054815 472.3479027 518.0630603 1.096782811 0.133277866 0.631024454 1 11.93576678 12.87188461 140467 zinc finger protein 358 "GO:0000978,GO:0003700,GO:0005634,GO:0006357,GO:0019827,GO:0021915,GO:0035115,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|stem cell population maintenance|neural tube development|embryonic forelimb morphogenesis|metal ion binding ZNF362 127.8526351 151.9004269 103.8048432 0.68337427 -0.549252167 0.201423844 1 1.892749615 1.271812145 149076 zinc finger protein 362 "GO:0000978,GO:0003700,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|metal ion binding ZNF365 122.1007906 114.4455271 129.7560541 1.133780038 0.181140774 0.691203671 1 1.354568072 1.510083005 22891 zinc finger protein 365 "GO:0000723,GO:0005515,GO:0005737,GO:0005813,GO:0010569,GO:0010977,GO:0021687,GO:0034451,GO:0043231,GO:0046872,GO:0048714,GO:0060997,GO:0110026,GO:0140059" telomere maintenance|protein binding|cytoplasm|centrosome|regulation of double-strand break repair via homologous recombination|negative regulation of neuron projection development|cerebellar molecular layer morphogenesis|centriolar satellite|intracellular membrane-bounded organelle|metal ion binding|positive regulation of oligodendrocyte differentiation|dendritic spine morphogenesis|regulation of DNA strand resection involved in replication fork processing|dendrite arborization ZNF367 452.1220402 451.5396251 452.7044553 1.002579685 0.003716907 0.998525504 1 4.967602535 4.897076846 195828 zinc finger protein 367 "GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0005654,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding" ZNF37A 316.6789227 352.7003062 280.6575392 0.795739426 -0.329632014 0.28774681 1 1.508008901 1.179902061 7587 zinc finger protein 37A "GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF383 89.8674675 100.9201466 78.81478839 0.78096189 -0.356675947 0.4704341 1 0.875475088 0.672271673 163087 zinc finger protein 383 "GO:0000978,GO:0003700,GO:0005515,GO:0005654,GO:0005737,GO:0006357,GO:0031965,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|nuclear membrane|metal ion binding hsa05168 Herpes simplex virus 1 infection ZNF384 954.4613494 1010.24188 898.6808189 0.88956995 -0.168820041 0.495571953 1 12.22002547 10.68866323 171017 zinc finger protein 384 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 ZNF385A 515.1469524 478.590386 551.7035187 1.152767659 0.205101766 0.452269216 1 8.092994072 9.173227926 25946 zinc finger protein 385A "GO:0000785,GO:0002039,GO:0003677,GO:0003723,GO:0003730,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006915,GO:0006974,GO:0006977,GO:0007599,GO:0007611,GO:0007626,GO:0008270,GO:0010609,GO:0030220,GO:0030425,GO:0035855,GO:0043025,GO:0045600,GO:0070889,GO:1901796,GO:1902164,GO:1902166,GO:2000765" "chromatin|p53 binding|DNA binding|RNA binding|mRNA 3'-UTR binding|nucleus|nucleoplasm|nucleolus|cytoplasm|apoptotic process|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|hemostasis|learning or memory|locomotory behavior|zinc ion binding|mRNA localization resulting in posttranscriptional regulation of gene expression|platelet formation|dendrite|megakaryocyte development|neuronal cell body|positive regulation of fat cell differentiation|platelet alpha granule organization|regulation of signal transduction by p53 class mediator|positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of cytoplasmic translation" ZNF385B 290.3616047 267.3863678 313.3368417 1.171850473 0.228788495 0.475692635 1 1.625460647 1.872922632 151126 zinc finger protein 385B "GO:0002039,GO:0003676,GO:0005634,GO:0008270,GO:0072332" p53 binding|nucleic acid binding|nucleus|zinc ion binding|intrinsic apoptotic signaling pathway by p53 class mediator ZNF385D 33.39262384 18.72744989 48.0577978 2.56616881 1.359616078 0.053882607 1 0.041636793 0.105059099 79750 zinc finger protein 385D "GO:0005634,GO:0008270,GO:1990837" nucleus|zinc ion binding|sequence-specific double-stranded DNA binding ZNF391 104.4779212 118.6071826 90.34865986 0.761746952 -0.392616272 0.399026278 1 1.33119818 0.997067634 346157 zinc finger protein 391 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF394 362.5319754 357.9023756 367.1615752 1.025870741 0.036848963 0.910959604 1 7.323846622 7.387594725 84124 zinc finger protein 394 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF395 1127.434209 1097.636646 1157.231771 1.054294037 0.076277283 0.756745728 1 12.2115594 12.65913569 55893 zinc finger protein 395 "GO:0000978,GO:0000987,GO:0001228,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0016607,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|nuclear speck|positive regulation of transcription by RNA polymerase II|metal ion binding" other ZNF396 53.83921041 63.46524684 44.21317398 0.69665173 -0.521490491 0.377967585 1 0.734552934 0.503164504 252884 zinc finger protein 396 "GO:0000785,GO:0000978,GO:0000981,GO:0005634,GO:0005737,GO:0006357,GO:0046872,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZNF397 367.6642334 442.1759001 293.1525666 0.66297726 -0.592968708 0.045053081 1 2.160999552 1.408719375 84307 zinc finger protein 397 "GO:0000978,GO:0000981,GO:0005515,GO:0005730,GO:0005829,GO:0005886,GO:0006357,GO:0015630,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleolus|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|microtubule cytoskeleton|metal ion binding" ZNF398 323.362355 364.1448589 282.5798511 0.776009448 -0.365853877 0.234546915 1 3.096023873 2.362340461 57541 zinc finger protein 398 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0045893,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|positive regulation of transcription, DNA-templated|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF404 105.1717353 86.35435226 123.9891183 1.435817826 0.521872714 0.25856301 1 2.492467857 3.518844583 342908 zinc finger protein 404 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF407 264.7274256 275.7096789 253.7451724 0.920334656 -0.11976954 0.724026608 1 0.716747958 0.648609669 55628 zinc finger protein 407 "GO:0003677,GO:0005634,GO:0008270,GO:0010468,GO:0045944" DNA binding|nucleus|zinc ion binding|regulation of gene expression|positive regulation of transcription by RNA polymerase II ZNF408 163.2914881 161.2641518 165.3188244 1.02514305 0.03582524 0.944191912 1 3.861090799 3.891935777 79797 zinc finger protein 408 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0042802,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|identical protein binding|metal ion binding" ZNF41 271.8266549 348.5386507 195.1146591 0.559807811 -0.836996478 0.010286879 0.610531935 3.057341749 1.682883759 7592 zinc finger protein 41 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF410 1306.416193 1279.709076 1333.123311 1.041739358 0.058994362 0.809010616 1 23.4371041 24.0067959 57862 zinc finger protein 410 "GO:0003712,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" transcription coregulator activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding zf-C2H2 ZNF414 80.028195 69.70773014 90.34865986 1.296106754 0.374184551 0.468542112 1 1.513496111 1.928826933 84330 zinc finger protein 414 "GO:0000785,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF415 133.342168 144.6175297 122.0668064 0.844066461 -0.244571496 0.572128501 1 2.570943292 2.133734207 55786 zinc finger protein 415 "GO:0000978,GO:0000981,GO:0001650,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0015630,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|fibrillar center|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|microtubule cytoskeleton|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF416 87.42997907 87.39476614 87.465192 1.000805836 0.001162108 1 1 1.46762053 1.444224759 55659 zinc finger protein 416 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF417 259.3668404 261.1438845 257.5897962 0.986390306 -0.019769473 0.965220761 1 2.371812314 2.300383763 147687 zinc finger protein 417 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF418 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.03009354 147686 zinc finger protein 418 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF419 155.4091261 143.5771158 167.2411363 1.164817495 0.220103929 0.5911659 1 2.021220466 2.314956051 79744 zinc finger protein 419 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF420 131.2267417 126.9304937 135.5229898 1.067694498 0.094498905 0.840960579 1 1.244542928 1.306556109 147923 zinc finger protein 420 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0042981,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|regulation of apoptotic process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF425 17.17185948 21.84869154 12.49502743 0.571889049 -0.806192815 0.388176961 1 0.364610541 0.20502753 155054 zinc finger protein 425 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0045892,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|negative regulation of transcription, DNA-templated|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF426 354.2482933 342.2961674 366.2004192 1.069834997 0.097388304 0.752403057 1 2.421810598 2.5475819 79088 zinc finger protein 426 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF428 232.7765357 256.982229 208.5708425 0.81161582 -0.301131109 0.383418162 1 11.80264135 9.41891532 126299 zinc finger protein 428 "GO:0005515,GO:0046872" protein binding|metal ion binding ZNF429 84.19488095 65.54607461 102.8436873 1.56902893 0.649871953 0.192586005 1 0.425142627 0.655898717 353088 zinc finger protein 429 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF43 117.6221033 97.79890497 137.4453017 1.405386919 0.490967375 0.269095732 1 0.43559905 0.601941116 7594 zinc finger protein 43 "GO:0000978,GO:0001228,GO:0003677,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF430 165.4220057 141.496288 189.3477233 1.338181559 0.420273868 0.284379414 1 1.9432313 2.556882181 80264 zinc finger protein 430 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0021762,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|substantia nigra development|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF431 342.5213074 324.6091314 360.4334835 1.110361504 0.151029457 0.623056655 1 1.230645218 1.3435952 170959 zinc finger protein 431 "GO:0000122,GO:0000978,GO:0000981,GO:0003682,GO:0005634,GO:0006355,GO:0030154,GO:0043433,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|chromatin binding|nucleus|regulation of transcription, DNA-templated|cell differentiation|negative regulation of DNA-binding transcription factor activity|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF432 170.4605288 160.2237379 180.6973197 1.127781202 0.173487201 0.663466729 1 1.748997017 1.939479076 9668 zinc finger protein 432 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF433 76.70377812 70.74814402 82.65941222 1.168361564 0.224486804 0.679299513 1 1.183604519 1.359737437 163059 zinc finger protein 433 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF436 299.0164244 355.8215479 242.2113009 0.680710042 -0.554887701 0.077806679 1 4.010462943 2.684280176 80818 zinc finger protein 436 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF438 315.3019698 291.3158871 339.2880525 1.164674044 0.219926246 0.481754946 1 1.434886339 1.643210027 220929 zinc finger protein 438 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF439 103.4871972 92.59683556 114.3775588 1.235221032 0.304769222 0.518784892 1 1.714090506 2.081850819 90594 zinc finger protein 439 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF44 159.8431539 171.6682906 148.0180172 0.86223272 -0.213850783 0.597673163 1 1.340986703 1.136894459 51710 zinc finger protein 44 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF440 176.9458163 166.4662212 187.4254114 1.125906566 0.171087109 0.663101377 1 1.920864059 2.126523375 126070 zinc finger protein 440 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF441 201.3263455 188.3149128 214.3377782 1.138188023 0.186738903 0.614486152 1 2.259447119 2.52864214 126068 zinc finger protein 441 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF442 26.06003687 28.09117483 24.0288989 0.855389603 -0.225346422 0.811740419 1 0.22001385 0.185048328 79973 zinc finger protein 442 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF443 89.91212689 89.47559391 90.34865986 1.009757588 0.014008987 1 1 1.855867858 1.84261819 10224 zinc finger protein 443 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0006915,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|apoptotic process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF444 244.7217881 229.9314681 259.5121081 1.128649812 0.174597928 0.611933465 1 2.832645396 3.143566144 55311 zinc finger protein 444 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZNF445 863.3307855 863.5435226 863.1180485 0.999507293 -0.000711001 1 1 2.516420808 2.473092802 353274 zinc finger protein 445 "GO:0000978,GO:0001228,GO:0003682,GO:0005634,GO:0006357,GO:0010216,GO:0010385,GO:0045944,GO:0046872,GO:0071517,GO:2000653" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|chromatin binding|nucleus|regulation of transcription by RNA polymerase II|maintenance of DNA methylation|double-stranded methylated DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding|maintenance of imprinting at mating-type locus|regulation of genetic imprinting" ZNF446 238.4000469 215.3656737 261.43442 1.21390942 0.279660774 0.415177241 1 5.0103183 5.980297333 55663 zinc finger protein 446 "GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005615,GO:0005634,GO:0006357,GO:0046872" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|extracellular space|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF449 376.9342235 395.3572754 358.5111716 0.906803021 -0.141138898 0.636606587 1 4.54240929 4.0501434 203523 zinc finger protein 449 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0007284,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|spermatogonial cell division|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 ZNF45 303.6391506 313.1645787 294.1137225 0.939166632 -0.090546944 0.781435832 1 3.99164509 3.686088451 7596 zinc finger protein 45 "GO:0000978,GO:0000981,GO:0005634,GO:0005654,GO:0006357,GO:0006367,GO:0007275,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|transcription initiation from RNA polymerase II promoter|multicellular organism development|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF451 1047.390922 1065.383816 1029.398029 0.966222702 -0.049572345 0.84309542 1 3.946250427 3.749152082 26036 zinc finger protein 451 "GO:0003714,GO:0005515,GO:0005634,GO:0010468,GO:0016605,GO:0016925,GO:0030512,GO:0045944,GO:0046872,GO:0060633,GO:0061665,GO:2000616" transcription corepressor activity|protein binding|nucleus|regulation of gene expression|PML body|protein sumoylation|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription by RNA polymerase II|metal ion binding|negative regulation of transcription initiation from RNA polymerase II promoter|SUMO ligase activity|negative regulation of histone H3-K9 acetylation ZNF460 27.98234878 28.09117483 27.87352272 0.99225194 -0.011221617 1 1 0.375450631 0.366307638 10794 zinc finger protein 460 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection ZNF461 64.41192592 63.46524684 65.35860501 1.029832991 0.042410394 0.969851733 1 0.680671941 0.689248497 92283 zinc finger protein 461 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF462 769.0683048 836.4927616 701.6438479 0.838792492 -0.253614147 0.316472032 1 3.052867488 2.517872107 58499 zinc finger protein 462 "GO:0003677,GO:0005515,GO:0005634,GO:0006325,GO:0010468,GO:0043392,GO:0045944,GO:0046872" DNA binding|protein binding|nucleus|chromatin organization|regulation of gene expression|negative regulation of DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding ZNF467 15.21494902 8.323311061 22.10658699 2.655984719 1.409246846 0.147519434 1 0.158134501 0.41297464 168544 zinc finger protein 467 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF468 370.9691429 390.155206 351.7830799 0.901649073 -0.149362057 0.618254837 1 4.367002154 3.871614657 90333 zinc finger protein 468 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF473 329.1638893 377.6702394 280.6575392 0.743128555 -0.428316289 0.161278963 1 4.342000549 3.17267073 25888 zinc finger protein 473 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006369,GO:0006398,GO:0008334,GO:0015030,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|termination of RNA polymerase II transcription|mRNA 3'-end processing by stem-loop binding and cleavage|histone mRNA metabolic process|Cajal body|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF48 231.6568639 252.8205735 210.4931544 0.832579214 -0.264340554 0.446219192 1 4.309348241 3.527835563 197407 zinc finger protein 48 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0042802,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|identical protein binding|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF480 211.1209586 230.9718819 191.2700352 0.828109611 -0.272106356 0.4488898 1 2.366848086 1.92721154 147657 zinc finger protein 480 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF483 228.9520336 207.0423626 250.8617045 1.211644329 0.276966266 0.426742136 1 0.661922385 0.788593877 158399 zinc finger protein 483 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF484 211.5222786 228.8910542 194.1535031 0.848235436 -0.237463341 0.509878785 1 2.446524109 2.040502307 83744 zinc finger protein 484 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF485 101.4805969 103.0009744 99.96021942 0.970478386 -0.043232012 0.948842244 1 0.940940208 0.897881603 220992 zinc finger protein 485 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF486 300.0920512 270.5076095 329.6764929 1.218732787 0.285381843 0.366716131 1 3.706416931 4.441543754 90649 zinc finger protein 486 "GO:0000978,GO:0000981,GO:0003674,GO:0005634,GO:0006355,GO:0006357,GO:0008150,GO:0046872,GO:0070062" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|biological_process|metal ion binding|extracellular exosome" hsa05168 Herpes simplex virus 1 infection ZNF487 71.06075969 61.38441908 80.7371003 1.315270251 0.395359264 0.463290303 1 1.023102319 1.323138313 642819 zinc finger protein 487 "GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF488 210.4372054 238.2547791 182.6196316 0.76648885 -0.38366329 0.283139962 1 3.135689191 2.363251973 118738 zinc finger protein 488 "GO:0003677,GO:0005515,GO:0005634,GO:0006355,GO:0014003,GO:0046872" "DNA binding|protein binding|nucleus|regulation of transcription, DNA-templated|oligodendrocyte development|metal ion binding" ZNF490 77.744192 72.82897178 82.65941222 1.134979805 0.182666628 0.740312109 1 0.636337323 0.71014447 57474 zinc finger protein 490 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF491 24.05846703 26.01034707 22.10658699 0.84991511 -0.234609344 0.811805789 1 0.346424861 0.289504808 126069 zinc finger protein 491 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF492 90.39270486 89.47559391 91.30981582 1.02049969 0.029275744 0.977550007 1 1.124622703 1.128472297 57615 zinc finger protein 492 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF493 143.5185939 134.2133909 152.823797 1.138662812 0.18734059 0.660560444 1 1.126568417 1.261315949 284443 zinc finger protein 493 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF496 1661.713118 1901.876577 1421.549659 0.747445799 -0.419959128 0.077235547 1 15.28379121 11.23264363 84838 zinc finger protein 496 "GO:0000978,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0045893,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription, DNA-templated|metal ion binding" ZNF497 2.40288989 0 4.80577978 Inf Inf 0.18976424 1 0 0.072780335 162968 zinc finger protein 497 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding ZNF500 189.0690918 194.5573961 183.5807876 0.943581644 -0.083780742 0.834510117 1 1.490335962 1.382721906 26048 zinc finger protein 500 "GO:0000978,GO:0000981,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|metal ion binding" ZNF501 65.8882584 76.99062732 54.78588949 0.711591676 -0.490878461 0.370954785 1 1.342760875 0.939508505 115560 zinc finger protein 501 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0005730,GO:0006357,GO:0007030,GO:0046872,GO:1990837" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleolus|regulation of transcription by RNA polymerase II|Golgi organization|metal ion binding|sequence-specific double-stranded DNA binding ZNF503 310.2483554 310.043337 310.4533738 1.001322514 0.001906724 1 1 5.162696743 5.083019492 84858 zinc finger protein 503 "GO:0005515,GO:0005634,GO:0008285,GO:0010629,GO:0045892,GO:0046872,GO:0061351,GO:0070315,GO:0070491" "protein binding|nucleus|negative regulation of cell population proliferation|negative regulation of gene expression|negative regulation of transcription, DNA-templated|metal ion binding|neural precursor cell proliferation|G1 to G0 transition involved in cell differentiation|repressing transcription factor binding" ZNF506 105.1321063 85.31393838 124.9502743 1.464593906 0.550500698 0.233009526 1 1.370161929 1.97315089 440515 zinc finger protein 506 "GO:0000978,GO:0000981,GO:0005730,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleolus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF507 618.0686688 682.511507 553.6258307 0.811159702 -0.301942113 0.248553878 1 4.720630473 3.765108979 22847 zinc finger protein 507 "GO:0003677,GO:0005634,GO:0010468,GO:0045944,GO:0046872" DNA binding|nucleus|regulation of gene expression|positive regulation of transcription by RNA polymerase II|metal ion binding ZNF510 405.2386344 419.2867947 391.1904741 0.932990209 -0.100066154 0.734905554 1 3.389875112 3.109796448 22869 zinc finger protein 510 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF511 237.8748095 226.8102264 248.9393926 1.09756688 0.134308853 0.702465335 1 11.16646211 12.05085244 118472 zinc finger protein 511 "GO:0000785,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF512 877.0599556 782.3912397 971.7286715 1.241998405 0.31266332 0.20944436 1 11.54084646 14.09385762 84450 zinc finger protein 512 "GO:0003677,GO:0005515,GO:0005634,GO:0046872" DNA binding|protein binding|nucleus|metal ion binding ZNF512B 827.86175 929.0895972 726.6339027 0.782092389 -0.354589051 0.156997626 1 6.689665975 5.144387467 57473 zinc finger protein 512B "GO:0003677,GO:0005515,GO:0005654,GO:0046872" DNA binding|protein binding|nucleoplasm|metal ion binding ZNF513 299.6655791 335.0132702 264.3178879 0.788977367 -0.34194418 0.278198558 1 7.297568369 5.661270367 130557 zinc finger protein 513 "GO:0000976,GO:0003677,GO:0005515,GO:0005634,GO:0007601,GO:0010468,GO:0045944,GO:0046872,GO:0050896,GO:0060041" transcription regulatory region sequence-specific DNA binding|DNA binding|protein binding|nucleus|visual perception|regulation of gene expression|positive regulation of transcription by RNA polymerase II|metal ion binding|response to stimulus|retina development in camera-type eye zf-C2H2 ZNF514 827.8327962 802.1591035 853.5064889 1.064011473 0.089513707 0.72450708 1 6.364816689 6.658913746 84874 zinc finger protein 514 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF516 1331.391157 1317.163975 1345.618338 1.021602749 0.030834312 0.901028063 1 6.8606891 6.891614416 9658 zinc finger protein 516 "GO:0000978,GO:0000981,GO:0000987,GO:0005634,GO:0006355,GO:0006357,GO:0009409,GO:0033613,GO:0045893,GO:0046872,GO:0050873,GO:0060612,GO:0120162" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|response to cold|activating transcription factor binding|positive regulation of transcription, DNA-templated|metal ion binding|brown fat cell differentiation|adipose tissue development|positive regulation of cold-induced thermogenesis" hsa04714 Thermogenesis ZNF517 58.7192177 78.0310412 39.4073942 0.505022022 -0.985581796 0.0814463 1 0.578304854 0.287169514 340385 zinc finger protein 517 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF518A 247.9518558 264.2651262 231.6385854 0.876538606 -0.19011046 0.577550787 1 1.101049581 0.948962615 9849 zinc finger protein 518A "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF518B 148.2199637 194.5573961 101.8825313 0.523663111 -0.933289115 0.022153306 0.822216713 1.005731368 0.517851402 85460 zinc finger protein 518B "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF519 170.9807358 161.2641518 180.6973197 1.120505194 0.164149336 0.681026557 1 1.273131863 1.402679468 162655 zinc finger protein 519 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF521 4.523346619 5.202069413 3.844623824 0.739056617 -0.436243205 0.933440272 1 0.029629123 0.021531173 25925 zinc finger protein 521 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0019904,GO:0045944,GO:0046872,GO:0048663" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|protein domain specific binding|positive regulation of transcription by RNA polymerase II|metal ion binding|neuron fate commitment" ZNF524 87.43500949 74.90979955 99.96021942 1.334407781 0.416199607 0.402443118 1 2.674112591 3.508645034 147807 zinc finger protein 524 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding ZNF525 221.1634063 254.9014012 187.4254114 0.73528592 -0.443622735 0.205258187 1 2.198387087 1.589394087 170958 zinc finger protein 525 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF526 249.9534256 266.345954 233.5608973 0.876907998 -0.189502606 0.577686277 1 3.569661989 3.077884401 116115 zinc finger protein 526 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF527 58.24367014 65.54607461 50.94126567 0.777182554 -0.363674579 0.534171652 1 0.640203795 0.489229307 84503 zinc finger protein 527 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF528 390.9999326 373.5085839 408.4912813 1.093659688 0.129163887 0.66293719 1 3.974769021 4.274302742 84436 zinc finger protein 528 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF529 281.1759029 303.8008537 258.5509522 0.851054067 -0.232677306 0.474199107 1 1.868106141 1.563255187 57711 zinc finger protein 529 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF530 131.1474838 124.8496659 137.4453017 1.10088642 0.138665631 0.759061805 1 1.315497968 1.42397995 348327 zinc finger protein 530 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF532 1170.352875 1328.608528 1012.097222 0.761772336 -0.392568199 0.105555527 1 8.727892081 6.537410302 55205 zinc finger protein 532 "GO:0003677,GO:0005634,GO:0046872" DNA binding|nucleus|metal ion binding ZNF540 19.77792461 14.56579436 24.99005486 1.715667148 0.778769686 0.377384239 1 0.223183943 0.37650189 163255 zinc finger protein 540 "GO:0000900,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0017148,GO:0043231,GO:0045892,GO:0046872" "translation repressor activity, mRNA regulatory element binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|negative regulation of translation|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF543 66.48772327 80.11186896 52.86357758 0.65987198 -0.599741937 0.269654241 1 1.158651276 0.75176761 125919 zinc finger protein 543 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF544 588.1841298 604.4804658 571.8877938 0.946081513 -0.079963605 0.767130606 1 3.325431551 3.0934831 27300 zinc finger protein 544 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF546 9.125951164 12.48496659 5.766935736 0.461910386 -1.11431511 0.374388992 1 0.084107513 0.03820003 339327 zinc finger protein 546 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF547 32.98627337 33.29324424 32.6793025 0.98155957 -0.026852269 1 1 0.64517039 0.622676202 284306 zinc finger protein 547 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF548 234.2975276 259.0630568 209.5319984 0.808806941 -0.306132717 0.37427555 1 2.627964114 2.08994799 147694 zinc finger protein 548 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF549 169.6975177 165.4258073 173.969228 1.051645029 0.072647822 0.865885638 1 2.15855044 2.232042982 256051 zinc finger protein 549 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF550 312.7355336 299.6391982 325.8318691 1.087414033 0.120901352 0.704572635 1 2.658994562 2.843043869 162972 zinc finger protein 550 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF551 164.4061295 177.9107739 150.9014851 0.848186323 -0.237546876 0.551523512 1 2.139425646 1.78426617 90233 zinc finger protein 551 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF552 74.38014615 72.82897178 75.93132052 1.042597728 0.060182621 0.935375011 1 1.077855899 1.10496534 79818 zinc finger protein 552 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF554 33.90780037 32.25283036 35.56277037 1.102624792 0.140941945 0.880620025 1 0.367950893 0.39892274 115196 zinc finger protein 554 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005654,GO:0005730,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF555 174.790761 147.7387713 201.8427508 1.366213817 0.450183288 0.240878126 1 0.910350617 1.222921394 148254 zinc finger protein 555 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF556 1.560620824 3.121241648 0 0 #NAME? 0.37822219 1 0.025338444 0 80032 zinc finger protein 556 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF557 66.09143364 69.70773014 62.47513714 0.896244032 -0.158036487 0.793996957 1 0.64732442 0.570452445 79230 zinc finger protein 557 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF558 430.4022964 385.9935505 474.8110423 1.230100974 0.298776745 0.293195707 1 2.598355999 3.142755493 148156 zinc finger protein 558 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF559 208.4507268 198.7190516 218.182402 1.097944059 0.134804549 0.716304718 1 2.013913892 2.174163943 84527 zinc finger protein 559 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF559-ZNF177 3.081612685 5.202069413 0.961155956 0.184764154 -2.436243205 0.338470402 1 0.078094201 0.014187559 100529215 ZNF559-ZNF177 readthrough "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:0072562,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|blood microparticle|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection ZNF561 468.3327437 473.3883166 463.2771708 0.978640905 -0.031148509 0.918654029 1 5.13493179 4.941163471 93134 zinc finger protein 561 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF562 655.043605 656.5011599 653.5860501 0.995559627 -0.006420369 0.986900731 1 2.69385363 2.637014086 54811 zinc finger protein 562 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF563 52.68494005 45.77821084 59.59166927 1.301747451 0.380449582 0.532154208 1 0.772643572 0.988956321 147837 zinc finger protein 563 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF564 143.880285 131.0921492 156.6684208 1.195101475 0.257133121 0.540342896 1 2.425007649 2.849633932 163050 zinc finger protein 564 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding hsa05168 Herpes simplex virus 1 infection ZNF565 27.02119282 28.09117483 25.95121081 0.923820772 -0.11431511 0.930963103 1 0.480043026 0.436052787 147929 zinc finger protein 565 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF566 164.6489337 171.6682906 157.6295768 0.918221858 -0.12308532 0.765765907 1 1.733513937 1.565114601 84924 zinc finger protein 566 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF567 158.3768823 133.172977 183.5807876 1.378513808 0.463113718 0.245448489 1 1.588555436 2.153201502 163081 zinc finger protein 567 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding hsa05168 Herpes simplex virus 1 infection ZNF568 128.9081402 116.5263549 141.2899255 1.212514763 0.278002313 0.524281637 1 0.704759451 0.840231815 374900 zinc finger protein 568 "GO:0000122,GO:0000976,GO:0000978,GO:0000981,GO:0001701,GO:0005634,GO:0006357,GO:0045892,GO:0046872,GO:0060669" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|in utero embryonic development|nucleus|regulation of transcription by RNA polymerase II|negative regulation of transcription, DNA-templated|metal ion binding|embryonic placenta morphogenesis" hsa05168 Herpes simplex virus 1 infection ZNF569 142.3938917 142.5367019 142.2510815 0.997996162 -0.002893827 1 1 1.603482675 1.573491212 148266 zinc finger protein 569 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF57 99.55828499 103.0009744 96.1155956 0.933152295 -0.09981554 0.851342755 1 2.482824162 2.278083666 126295 zinc finger protein 57 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF570 108.4911218 97.79890497 119.1833385 1.218657188 0.285292349 0.539823994 1 0.931028864 1.115618939 148268 zinc finger protein 570 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF571 43.83639163 40.57614142 47.09664184 1.160697893 0.214992515 0.761599135 1 0.547943849 0.625354718 51276 zinc finger protein 571 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF572 115.9325348 116.5263549 115.3387147 0.98980797 -0.014779436 0.99567794 1 1.897131602 1.846373607 137209 zinc finger protein 572 "GO:0000122,GO:0000978,GO:0001227,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0042802,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|identical protein binding|metal ion binding" ZNF573 48.19619198 54.1015219 42.29086206 0.781694499 -0.355323209 0.575293564 1 1.068183052 0.821020342 126231 zinc finger protein 573 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF574 238.2264398 248.658918 227.7939616 0.916090054 -0.126438669 0.71959643 1 3.426405741 3.086371043 64763 zinc finger protein 574 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF575 8.927806347 7.282897178 10.57271552 1.451718356 0.537761587 0.724794316 1 0.19521589 0.278656201 284346 zinc finger protein 575 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF576 118.5385999 109.2434577 127.8337421 1.170172978 0.226721808 0.61830307 1 2.104737385 2.421693402 79177 zinc finger protein 576 "GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0043565,GO:0046872" "DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|metal ion binding" ZNF577 27.38288391 24.96993318 29.79583464 1.193268497 0.2549187 0.774245821 1 0.128728694 0.151037475 84765 zinc finger protein 577 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF578 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.022160269 147660 zinc finger protein 578 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF579 253.2482744 239.295193 267.2013558 1.11661815 0.159135912 0.640657791 1 4.375040988 4.80350213 163033 zinc finger protein 579 "GO:0003677,GO:0003723,GO:0005634,GO:0046872" DNA binding|RNA binding|nucleus|metal ion binding ZNF580 246.0496656 214.3252598 277.7740713 1.296039821 0.374110045 0.268107138 1 7.144375518 9.104451725 51157 zinc finger protein 580 "GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001938,GO:0002690,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006935,GO:0006954,GO:0010595,GO:0010628,GO:0032757,GO:0045944,GO:0046872,GO:0070301,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|positive regulation of endothelial cell proliferation|positive regulation of leukocyte chemotaxis|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|chemotaxis|inflammatory response|positive regulation of endothelial cell migration|positive regulation of gene expression|positive regulation of interleukin-8 production|positive regulation of transcription by RNA polymerase II|metal ion binding|cellular response to hydrogen peroxide|sequence-specific double-stranded DNA binding" ZNF581 784.7248172 742.8555122 826.5941222 1.112725299 0.154097476 0.543520773 1 27.098314 29.64841027 51545 zinc finger protein 581 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding ZNF582 12.049048 13.52538047 10.57271552 0.781694499 -0.355323209 0.80166462 1 0.235813361 0.181249427 147948 zinc finger protein 582 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF583 30.50915598 18.72744989 42.29086206 2.258228553 1.175191507 0.106269766 1 0.222892413 0.494919265 147949 zinc finger protein 583 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF584 198.5221355 190.3957405 206.6485305 1.085363202 0.118177901 0.756882402 1 2.693101177 2.874080588 201514 zinc finger protein 584 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF585A 250.6573005 209.1231904 292.1914106 1.397221466 0.482560712 0.149656658 1 1.278556572 1.756533257 199704 zinc finger protein 585A "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF585B 166.4127298 167.5066351 165.3188244 0.986938961 -0.018967233 0.978493489 1 1.442556277 1.399891051 92285 zinc finger protein 585B "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF586 134.4272413 135.2538047 133.6006779 0.987777594 -0.01774185 0.986421436 1 3.213823229 3.121420907 54807 zinc finger protein 586 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF587 925.0970174 933.2512527 916.942782 0.982525102 -0.025433829 0.922735228 1 7.233973001 6.988624667 84914 zinc finger protein 587 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF587B 95.15382526 100.9201466 89.38750391 0.88572507 -0.175069141 0.729444488 1 1.614969338 1.406482708 100293516 zinc finger protein 587B "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF589 355.5013289 413.0443114 297.9583464 0.721371383 -0.471185902 0.114759603 1 6.546901027 4.643718275 51385 zinc finger protein 589 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0005654,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF592 943.9427398 1074.747541 813.1379388 0.756585066 -0.402425796 0.103362922 1 7.110996894 5.290045799 9640 zinc finger protein 592 "GO:0003677,GO:0005515,GO:0005634,GO:0046872" DNA binding|protein binding|nucleus|metal ion binding ZNF593 210.9674732 214.3252598 207.6096865 0.96866644 -0.045928135 0.911082538 1 17.92812728 17.07577246 51042 zinc finger protein 593 "GO:0003677,GO:0005515,GO:0005654,GO:0005730,GO:0008270,GO:0045944,GO:1903026" DNA binding|protein binding|nucleoplasm|nucleolus|zinc ion binding|positive regulation of transcription by RNA polymerase II|negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding ZNF594 94.90599065 119.6475965 70.16438479 0.586425359 -0.769980602 0.105965844 1 1.232935378 0.710925735 84622 zinc finger protein 594 "GO:0000978,GO:0001228,GO:0005634,GO:0005654,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF595 180.3249534 129.0113214 231.6385854 1.795490371 0.844377916 0.025919932 0.86539048 1.897766569 3.350403015 152687 zinc finger protein 595 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection other ZNF596 11.04826308 12.48496659 9.61155956 0.769850643 -0.377349516 0.799003187 1 0.136873402 0.103608818 169270 zinc finger protein 596 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF598 1168.143714 1245.375418 1090.91201 0.875970406 -0.191045965 0.431895788 1 19.73964869 17.00200078 90850 "zinc finger protein 598, E3 ubiquitin ligase" "GO:0003723,GO:0005515,GO:0006513,GO:0016567,GO:0043022,GO:0046872,GO:0061630,GO:0072344" RNA binding|protein binding|protein monoubiquitination|protein ubiquitination|ribosome binding|metal ion binding|ubiquitin protein ligase activity|rescue of stalled ribosome ZNF599 44.11882479 35.37407201 52.86357758 1.494415954 0.579581762 0.363964357 1 0.526890653 0.774217829 148103 zinc finger protein 599 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF600 340.6581318 376.6298255 304.686438 0.808981173 -0.305821967 0.313616015 1 4.260288591 3.388820864 162966 zinc finger protein 600 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF605 270.9799698 263.2247123 278.7352272 1.058924995 0.082600405 0.810088529 1 1.488905046 1.550255854 100289635 zinc finger protein 605 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF606 43.51432951 44.73779695 42.29086206 0.945304976 -0.081148246 0.936132233 1 0.581201071 0.540218594 80095 zinc finger protein 606 "GO:0000978,GO:0001228,GO:0005634,GO:0005654,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF607 130.1466989 123.809252 136.4841458 1.102374366 0.140614246 0.756255133 1 1.323347132 1.434412513 84775 zinc finger protein 607 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF608 6.564545421 8.323311061 4.80577978 0.577387982 -0.792387015 0.636893371 1 0.056363382 0.031998967 57507 zinc finger protein 608 "GO:0000122,GO:0005634,GO:0006357,GO:0046872" negative regulation of transcription by RNA polymerase II|nucleus|regulation of transcription by RNA polymerase II|metal ion binding ZNF609 1903.245082 1997.594655 1808.895509 0.905536819 -0.143154793 0.546318152 1 11.73191981 10.44591236 23060 zinc finger protein 609 "GO:0005634,GO:0005654,GO:0006357,GO:0007517,GO:0045944,GO:0046872,GO:1990841,GO:2000291,GO:2001224" nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|muscle organ development|positive regulation of transcription by RNA polymerase II|metal ion binding|promoter-specific chromatin binding|regulation of myoblast proliferation|positive regulation of neuron migration ZNF610 56.32638864 53.06110801 59.59166927 1.123076232 0.167455859 0.797003718 1 0.93181106 1.028983181 162963 zinc finger protein 610 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF611 254.7095156 290.2754733 219.143558 0.754950308 -0.405546408 0.223511727 1 3.293954604 2.445159281 81856 zinc finger protein 611 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF613 72.21503004 79.07145508 65.35860501 0.82657648 -0.274779782 0.615257533 1 1.354267725 1.100674108 79898 zinc finger protein 613 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding hsa05168 Herpes simplex virus 1 infection ZNF614 203.1197097 210.1636043 196.075815 0.932967512 -0.100101251 0.793330546 1 2.423518863 2.223228514 80110 zinc finger protein 614 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0003674,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|molecular_function|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF615 174.0227195 165.4258073 182.6196316 1.103936771 0.142657543 0.72102965 1 1.929720502 2.094641912 284370 zinc finger protein 615 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF616 177.2578176 187.2744989 167.2411363 0.893026746 -0.16322471 0.677942481 1 2.294420525 2.014692009 90317 zinc finger protein 616 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF618 612.0092391 712.6835096 511.3349686 0.717478322 -0.478992852 0.067347083 1 1.532232569 1.080947625 114991 zinc finger protein 618 "GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005721,GO:0006355,GO:0008134,GO:0035563,GO:0042802,GO:0046872" "DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|pericentric heterochromatin|regulation of transcription, DNA-templated|transcription factor binding|positive regulation of chromatin binding|identical protein binding|metal ion binding" ZNF619 99.07267659 115.485941 82.65941222 0.71575303 -0.482466222 0.30663677 1 2.572317369 1.810334901 285267 zinc finger protein 619 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF620 96.19423914 103.0009744 89.38750391 0.867831634 -0.204512919 0.680852593 1 0.900110151 0.768072676 253639 zinc finger protein 620 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF621 1314.451426 1414.96288 1213.939972 0.857930614 -0.221067122 0.358367042 1 7.939645498 6.697680948 285268 zinc finger protein 621 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF622 837.5185833 816.7248979 858.3122687 1.05091968 0.071652411 0.778581277 1 25.53433317 26.38549368 90441 zinc finger protein 622 "GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005794,GO:0005829,GO:0008270,GO:0008631,GO:0030687,GO:0033674,GO:0042273,GO:0043065,GO:0043410,GO:0046330" "RNA binding|protein binding|nucleoplasm|nucleolus|Golgi apparatus|cytosol|zinc ion binding|intrinsic apoptotic signaling pathway in response to oxidative stress|preribosome, large subunit precursor|positive regulation of kinase activity|ribosomal large subunit biogenesis|positive regulation of apoptotic process|positive regulation of MAPK cascade|positive regulation of JNK cascade" ZNF623 748.6512863 817.7653118 679.5372609 0.830968557 -0.267134207 0.292959891 1 9.668283496 7.899600811 9831 zinc finger protein 623 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF624 111.7262199 119.6475965 103.8048432 0.867588203 -0.204917659 0.661512919 1 1.101496002 0.939653513 57547 zinc finger protein 624 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF625 53.00700218 41.61655531 64.39744905 1.547399793 0.629845986 0.287712715 1 1.304934823 1.985466362 90589 zinc finger protein 625 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF626 92.39930512 79.07145508 105.7271552 1.337109012 0.41911709 0.389318835 1 0.619389143 0.814332153 199777 zinc finger protein 626 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" ZNF627 272.8626527 262.1842984 283.541007 1.081456856 0.112976111 0.737175196 1 4.577132526 4.867140283 199692 zinc finger protein 627 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF628 86.94940109 87.39476614 86.50403604 0.98980797 -0.014779436 1 1 0.821144022 0.79917421 89887 zinc finger protein 628 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0007283,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|spermatogenesis|metal ion binding" ZNF629 569.4466191 591.9954992 546.897739 0.923820772 -0.11431511 0.671290922 1 5.177599435 4.703133968 23361 zinc finger protein 629 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF630 91.07142766 94.67766332 87.465192 0.923820772 -0.11431511 0.833669667 1 1.422514888 1.292158301 57232 zinc finger protein 630 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF638 1904.889377 2091.231904 1718.546849 0.821786836 -0.283163875 0.231808147 1 16.40529225 13.256056 27332 zinc finger protein 638 "GO:0003690,GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0008270,GO:0008380,GO:0016607,GO:0043231" double-stranded DNA binding|RNA binding|nucleus|nucleoplasm|cytoplasm|zinc ion binding|RNA splicing|nuclear speck|intracellular membrane-bounded organelle ZNF639 728.0166158 742.8555122 713.1777193 0.960049037 -0.058819997 0.822192389 1 10.71192472 10.11188465 51193 zinc finger protein 639 "GO:0000976,GO:0000978,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0030307,GO:0043621,GO:0043922,GO:0043923,GO:0045892,GO:0045944,GO:0046718,GO:0046872" "transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|positive regulation of cell growth|protein self-association|negative regulation by host of viral transcription|positive regulation by host of viral transcription|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|viral entry into host cell|metal ion binding" zf-C2H2 ZNF641 132.901219 145.6579436 120.1444945 0.824839975 -0.277813842 0.51938791 1 0.713492129 0.578668797 121274 zinc finger protein 641 "GO:0000978,GO:0000981,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF644 806.4294697 845.8564866 767.0024529 0.906776108 -0.141181716 0.576761548 1 6.415833722 5.720372988 84146 zinc finger protein 644 "GO:0000978,GO:0000981,GO:0001226,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II transcription corepressor binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF646 600.7879833 632.5716406 569.0043259 0.899509699 -0.152789258 0.564129442 1 4.339784785 3.838355732 9726 zinc finger protein 646 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" ZNF649 74.29585781 83.23311061 65.35860501 0.785247656 -0.348780364 0.512285091 1 1.391603426 1.074467582 65251 zinc finger protein 649 "GO:0000978,GO:0003700,GO:0005515,GO:0005615,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|extracellular space|nucleus|regulation of transcription by RNA polymerase II|metal ion binding hsa05168 Herpes simplex virus 1 infection ZNF652 310.3427046 274.669265 346.0161442 1.259755598 0.333143867 0.285975818 1 1.228614018 1.52185383 22834 zinc finger protein 652 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF653 73.93919714 73.86938567 74.00900861 1.001890133 0.002724311 1 1 1.830210467 1.802985827 115950 zinc finger protein 653 "GO:0003677,GO:0003712,GO:0003714,GO:0005515,GO:0005576,GO:0005634,GO:0006357,GO:0008134,GO:0045892,GO:0046872,GO:0050682,GO:1900116,GO:1903507" "DNA binding|transcription coregulator activity|transcription corepressor activity|protein binding|extracellular region|nucleus|regulation of transcription by RNA polymerase II|transcription factor binding|negative regulation of transcription, DNA-templated|metal ion binding|AF-2 domain binding|extracellular negative regulation of signal transduction|negative regulation of nucleic acid-templated transcription" ZNF654 501.2944794 468.1862472 534.4027115 1.141431887 0.190844772 0.487540645 1 3.517702312 3.948028359 55279 zinc finger protein 654 "GO:0000981,GO:0003677,GO:0005634,GO:0006357,GO:0046872" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF655 623.7368394 629.450399 618.0232797 0.981845878 -0.026431515 0.925800246 1 5.626903001 5.432302283 79027 zinc finger protein 655 "GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0006357,GO:0046872,GO:2000134" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|nucleolus|cytoplasm|regulation of transcription by RNA polymerase II|metal ion binding|negative regulation of G1/S transition of mitotic cell cycle" ZNF658 81.49949706 95.7180772 67.28091692 0.702907109 -0.508594049 0.314964711 1 0.742485154 0.513164835 26149 zinc finger protein 658 "GO:0000976,GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0042254,GO:0045892,GO:0045944,GO:0046872,GO:0071294" "transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|ribosome biogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|cellular response to zinc ion" hsa05168 Herpes simplex virus 1 infection ZNF66 23.21619796 29.13158871 17.30080721 0.593884782 -0.751745031 0.358781224 1 0.342520235 0.200013638 7617 zinc finger protein 66 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" ZNF660 8.566115259 10.40413883 6.728091692 0.64667454 -0.628888283 0.669388466 1 0.095174797 0.060517211 285349 zinc finger protein 660 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding ZNF664 2602.38739 2739.409753 2465.365027 0.899962127 -0.152063805 0.520589119 1 34.29445548 30.34724868 144348 zinc finger protein 664 "GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0008150,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" ZNF665 103.7199405 111.3242854 96.1155956 0.863383899 -0.211925907 0.659532057 1 1.277946334 1.084895082 79788 zinc finger protein 665 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF667 1.441733934 0 2.883467868 Inf Inf 0.442025237 1 0 0.019551663 63934 zinc finger protein 667 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF668 196.0745863 201.8402932 190.3088793 0.942868623 -0.084871332 0.829339206 1 2.840676551 2.633565645 79759 zinc finger protein 668 "GO:0000122,GO:0000978,GO:0001227,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZNF669 153.5660721 145.6579436 161.4742006 1.108584926 0.148719296 0.723638049 1 3.95799223 4.314347127 79862 zinc finger protein 669 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF670 220.30163 207.0423626 233.5608973 1.128082651 0.173872773 0.627665795 1 2.632706783 2.92021341 93474 zinc finger protein 670 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF672 701.7584341 709.562268 693.9546002 0.978003808 -0.032088012 0.905959478 1 12.41574889 11.9394589 79894 zinc finger protein 672 "GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0043565,GO:0046872" "DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|metal ion binding" ZNF674 107.921225 120.6880104 95.15443964 0.788433245 -0.342939485 0.4580404 1 1.501724714 1.164196891 641339 zinc finger protein 674 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF675 348.3725315 314.2049926 382.5400705 1.217485653 0.283904771 0.347063785 1 7.255968398 8.68621177 171392 zinc finger protein 675 "GO:0000122,GO:0000978,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006355,GO:0007249,GO:0008270,GO:0010804,GO:0019221,GO:0031625,GO:0032088,GO:0043508,GO:0045453,GO:0045671,GO:0046329,GO:0048471,GO:2000660,GO:2000678" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription, DNA-templated|I-kappaB kinase/NF-kappaB signaling|zinc ion binding|negative regulation of tumor necrosis factor-mediated signaling pathway|cytokine-mediated signaling pathway|ubiquitin protein ligase binding|negative regulation of NF-kappaB transcription factor activity|negative regulation of JUN kinase activity|bone resorption|negative regulation of osteoclast differentiation|negative regulation of JNK cascade|perinuclear region of cytoplasm|negative regulation of interleukin-1-mediated signaling pathway|negative regulation of transcription regulatory region DNA binding" hsa05168 Herpes simplex virus 1 infection ZNF676 38.03485735 27.05076095 49.01895376 1.812109975 0.857670514 0.199389969 1 0.490037133 0.87314168 163223 zinc finger protein 676 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF678 240.3865255 254.9014012 225.8716497 0.886113801 -0.174436102 0.614431367 1 1.575222244 1.37246891 339500 zinc finger protein 678 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" ZNF679 3.081612685 5.202069413 0.961155956 0.184764154 -2.436243205 0.338470402 1 0.162639065 0.029547025 168417 zinc finger protein 679 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF680 168.3847315 143.5771158 193.1923472 1.345565037 0.428212124 0.271918649 1 1.395964071 1.846928629 340252 zinc finger protein 680 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF681 267.4328704 220.5677431 314.2979976 1.424949964 0.510911261 0.118908809 1 1.811804689 2.538529254 148213 zinc finger protein 681 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF682 59.97286765 47.8590386 72.0866967 1.506229519 0.590941625 0.296721657 1 0.704398491 1.04323164 91120 zinc finger protein 682 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF684 87.35072114 85.31393838 89.38750391 1.047747948 0.067291697 0.915139963 1 2.25510059 2.323239143 127396 zinc finger protein 684 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection ZNF687 786.998145 865.6243504 708.3719396 0.818336429 -0.289234019 0.25154552 1 7.385576439 5.942749997 57592 zinc finger protein 687 "GO:0003677,GO:0005515,GO:0005654,GO:0005829,GO:0046872" DNA binding|protein binding|nucleoplasm|cytosol|metal ion binding ZNF688 93.27617273 89.47559391 97.07675156 1.084952302 0.117631618 0.826454081 1 2.031977871 2.167708089 146542 zinc finger protein 688 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0003674,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|molecular_function|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF689 270.5635585 302.7604398 238.3666771 0.787311173 -0.344994142 0.291504054 1 4.542526912 3.516536279 115509 zinc finger protein 689 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0035914,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|skeletal muscle cell differentiation|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF69 79.26518386 74.90979955 83.62056817 1.116283433 0.158703384 0.775163162 1 1.055106446 1.158088993 7620 zinc finger protein 69 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF691 171.773315 182.0724295 161.4742006 0.886867941 -0.173208799 0.662715812 1 3.15893073 2.754674173 51058 zinc finger protein 691 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding ZNF692 420.889502 439.0546585 402.7243456 0.917253325 -0.124607865 0.667659885 1 8.95701077 8.078366827 55657 zinc finger protein 692 "GO:0000122,GO:0000978,GO:0001227,GO:0003700,GO:0005515,GO:0005654,GO:0005730,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF695 116.5319997 119.6475965 113.4164028 0.947920444 -0.077162111 0.880854271 1 1.716036636 1.599446154 57116 zinc finger protein 695 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" ZNF696 248.0808035 242.4164347 253.7451724 1.046732548 0.065892865 0.855942752 1 2.777440871 2.858589073 79943 zinc finger protein 696 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF697 836.2297204 934.2916666 738.1677742 0.790082798 -0.339924244 0.174413489 1 5.757006015 4.472398242 90874 zinc finger protein 697 "GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" ZNF699 248.9727624 215.3656737 282.5798511 1.31209327 0.391870277 0.243848092 1 1.700750249 2.194201106 374879 zinc finger protein 699 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF7 609.6862215 613.8441908 605.5282523 0.986452688 -0.019678236 0.946915891 1 6.876518947 6.669850249 7553 zinc finger protein 7 "GO:0000978,GO:0000981,GO:0003677,GO:0005634,GO:0006357,GO:0007275,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF70 153.1150622 171.6682906 134.5618338 0.783847928 -0.351354307 0.386285655 1 1.289824181 0.99410786 7621 zinc finger protein 70 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF700 309.7331789 296.5179566 322.9484012 1.089136068 0.123184204 0.699983462 1 5.548603915 5.942060138 90592 zinc finger protein 700 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF701 270.9699089 288.1946455 253.7451724 0.880464562 -0.183663157 0.579079447 1 2.753879776 2.384119589 55762 zinc finger protein 701 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF703 165.9321518 167.5066351 164.3576685 0.981200944 -0.027379473 0.961038028 1 2.695874925 2.600931265 80139 zinc finger protein 703 "GO:0005515,GO:0005634,GO:0005737,GO:0006355,GO:0008284,GO:0010718,GO:0016363,GO:0017015,GO:0030335,GO:0032991,GO:0033601,GO:0034111,GO:0034333,GO:0045892,GO:0046872,GO:0051726,GO:0060644,GO:0060828,GO:0070491,GO:0071392" "protein binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|positive regulation of cell population proliferation|positive regulation of epithelial to mesenchymal transition|nuclear matrix|regulation of transforming growth factor beta receptor signaling pathway|positive regulation of cell migration|protein-containing complex|positive regulation of mammary gland epithelial cell proliferation|negative regulation of homotypic cell-cell adhesion|adherens junction assembly|negative regulation of transcription, DNA-templated|metal ion binding|regulation of cell cycle|mammary gland epithelial cell differentiation|regulation of canonical Wnt signaling pathway|repressing transcription factor binding|cellular response to estradiol stimulus" ZNF704 40.71011957 46.81862472 34.60161442 0.739056617 -0.436243205 0.514910212 1 0.160487119 0.116624305 619279 zinc finger protein 704 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding ZNF705E 3.081612685 5.202069413 0.961155956 0.184764154 -2.436243205 0.338470402 1 0.080517658 0.014627834 100131539 zinc finger protein 705E "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF706 1881.327808 1825.926364 1936.729251 1.060683108 0.084993698 0.721254515 1 23.35162572 24.35420472 51123 zinc finger protein 706 "GO:0005634,GO:0005737,GO:0006417,GO:0045892,GO:0046872,GO:1902455" "nucleus|cytoplasm|regulation of translation|negative regulation of transcription, DNA-templated|metal ion binding|negative regulation of stem cell population maintenance" other ZNF707 311.9624617 329.8112008 294.1137225 0.8917639 -0.165266297 0.600580253 1 5.571832105 4.885613277 286075 zinc finger protein 707 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding hsa05168 Herpes simplex virus 1 infection ZNF708 98.2008394 92.59683556 103.8048432 1.121040936 0.164838961 0.743104901 1 0.987159994 1.088128529 7562 zinc finger protein 708 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF709 75.46521942 63.46524684 87.465192 1.378158856 0.462742193 0.376620794 1 0.691652763 0.937256746 163051 zinc finger protein 709 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF710 221.9811377 213.2848459 230.6774294 1.081546269 0.113095386 0.756634234 1 3.041042006 3.233990213 374655 zinc finger protein 710 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding ZNF711 390.3061185 405.7614142 374.8508228 0.923820772 -0.11431511 0.700789124 1 3.903865318 3.546122448 7552 zinc finger protein 711 "GO:0005515,GO:0005634,GO:0010468,GO:0043565,GO:0045893,GO:0046872" "protein binding|nucleus|regulation of gene expression|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|metal ion binding" zf-C2H2 ZNF713 23.7364049 30.1720026 17.30080721 0.573405996 -0.802371104 0.320784064 1 0.369486995 0.208320767 349075 zinc finger protein 713 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" hsa05168 Herpes simplex virus 1 infection ZNF714 521.7165282 474.4287305 569.0043259 1.199346265 0.262248242 0.333856489 1 2.892983248 3.411628112 148206 zinc finger protein 714 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF717 137.3503381 136.2942186 138.4064577 1.015497642 0.02218689 0.977334554 1 1.424274907 1.422145138 100131827 zinc finger protein 717 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF718 103.4821667 105.0818021 101.8825313 0.969554473 -0.044606138 0.945592006 1 0.922523877 0.879469957 255403 zinc finger protein 718 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF720 105.8850566 105.0818021 106.6883111 1.015288175 0.021889274 0.985347629 1 2.032628724 2.029170617 124411 zinc finger protein 720 "GO:0005515,GO:0006355" "protein binding|regulation of transcription, DNA-templated" ZNF721 443.917616 438.0142446 449.8209874 1.026955157 0.038373187 0.899666209 1 5.0023572 5.051232498 170960 zinc finger protein 721 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF724 120.2577366 116.5263549 123.9891183 1.064043567 0.089557223 0.85631415 1 2.15930465 2.259147095 440519 zinc finger protein 724 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" ZNF726 137.4295961 138.3750464 136.4841458 0.986334959 -0.019850426 0.981752957 1 0.995393167 0.965362134 730087 zinc finger protein 726 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF730 87.91558746 74.90979955 100.9213754 1.347238625 0.430005406 0.385521319 1 1.180336086 1.563584617 100129543 zinc finger protein 730 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF736 251.1278177 234.0931236 268.1625117 1.145537757 0.196025011 0.563858592 1 1.336591394 1.505494756 728927 zinc finger protein 736 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF737 145.8472563 119.6475965 172.0469161 1.437947114 0.524010616 0.202133417 1 0.730174079 1.03238219 100129842 zinc finger protein 737 "GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF738 274.6214184 270.5076095 278.7352272 1.030415476 0.043226167 0.905628871 1 1.548149485 1.568543055 148203 zinc finger protein 738 "GO:0000209,GO:0003677,GO:0004842,GO:0005634,GO:0006355" "protein polyubiquitination|DNA binding|ubiquitin-protein transferase activity|nucleus|regulation of transcription, DNA-templated" ZNF74 282.3949544 260.1034707 304.686438 1.171404739 0.228239636 0.482515823 1 3.780295256 4.354154912 7625 zinc finger protein 74 "GO:0000978,GO:0000981,GO:0003723,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0007275,GO:0015629,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|actin cytoskeleton|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF740 1035.653876 1072.666713 998.6410383 0.930989119 -0.103163788 0.676275522 1 6.684522536 6.119080626 283337 zinc finger protein 740 "GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZNF746 390.6577488 427.6101058 353.7053918 0.82716799 -0.273747738 0.348455296 1 5.281362053 4.295471472 155061 zinc finger protein 746 "GO:0000122,GO:0000976,GO:0000978,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0031625,GO:0045892,GO:0045944,GO:0046872,GO:1901216" "negative regulation of transcription by RNA polymerase II|transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|ubiquitin protein ligase binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of neuron death" hsa05168 Herpes simplex virus 1 infection ZNF747 125.5290031 153.9812546 97.07675156 0.630445256 -0.665556993 0.123432121 1 2.384014086 1.477839863 65988 zinc finger protein 747 "GO:0005515,GO:0006355" "protein binding|regulation of transcription, DNA-templated" ZNF749 176.9407859 178.9511878 174.930384 0.977531282 -0.032785224 0.947422334 1 2.260425088 2.172660963 388567 zinc finger protein 749 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF75A 127.2135412 147.7387713 106.6883111 0.722141589 -0.469646363 0.276657443 1 1.59444827 1.132149996 7627 zinc finger protein 75a "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0008150,GO:0046872,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 ZNF75D 319.379337 310.043337 328.7153369 1.060223839 0.084368885 0.793323101 1 2.168603285 2.260730819 7626 zinc finger protein 75D "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding" ZNF76 282.8554107 310.043337 255.6674843 0.824618541 -0.278201195 0.389667594 1 4.541982723 3.682728918 7629 zinc finger protein 76 "GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0006359,GO:0043565,GO:0045944,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|regulation of transcription by RNA polymerase III|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 ZNF761 19.57474937 21.84869154 17.30080721 0.791846376 -0.336707531 0.738837466 1 0.254701728 0.198309721 388561 zinc finger protein 761 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF763 13.97135991 13.52538047 14.41733934 1.065947044 0.092135768 1 1 0.249766331 0.261782556 284390 zinc finger protein 763 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding hsa05168 Herpes simplex virus 1 infection ZNF764 161.3295472 160.2237379 162.4353566 1.013803314 0.019777786 0.977731492 1 3.001350093 2.991861892 92595 zinc finger protein 764 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF765 159.6053801 165.4258073 153.784953 0.929630965 -0.10526997 0.804180376 1 1.930986723 1.765066399 91661 zinc finger protein 765 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF765-ZNF761 6.445658531 5.202069413 7.689247648 1.478113235 0.563756795 0.78195947 1 0.051815021 0.075306864 110116772 ZNF765-ZNF761 readthrough "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF766 331.1409214 341.2557535 321.0260893 0.940719932 -0.088162822 0.780984651 1 3.55429203 3.287642851 90321 zinc finger protein 766 "GO:0003677,GO:0005515,GO:0005634,GO:0006355,GO:0046872" "DNA binding|protein binding|nucleus|regulation of transcription, DNA-templated|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF768 676.1141942 742.8555122 609.3728761 0.820311442 -0.285756344 0.267619979 1 10.68305938 8.616791613 79724 zinc finger protein 768 "GO:0000977,GO:0000981,GO:0003723,GO:0005515,GO:0005634,GO:0006357,GO:0006366,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF77 68.77675669 64.50566072 73.04785266 1.132425462 0.179416093 0.758705764 1 1.667093732 1.85626862 58492 zinc finger protein 77 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0003674,GO:0005515,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF770 1089.403767 1159.021065 1019.786469 0.879868796 -0.184639686 0.450244306 1 11.50359384 9.9522811 54989 zinc finger protein 770 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF771 66.69089851 72.82897178 60.55282523 0.831438695 -0.266318203 0.638305446 1 1.866833991 1.526184754 51333 zinc finger protein 771 "GO:0000978,GO:0000981,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZNF772 221.4162714 223.6889848 219.143558 0.979679702 -0.029617945 0.946451225 1 2.10581584 2.028503104 400720 zinc finger protein 772 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF773 108.803123 118.6071826 98.99906347 0.834680171 -0.260704597 0.576097444 1 0.81802111 0.671360501 374928 zinc finger protein 773 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF774 69.96562559 95.7180772 44.21317398 0.461910386 -1.11431511 0.036262086 0.964754921 1.259131836 0.571873682 342132 zinc finger protein 774 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" zf-C2H2 ZNF775 132.3810121 144.6175297 120.1444945 0.830774075 -0.267471898 0.536264805 1 3.413521346 2.788410679 285971 zinc finger protein 775 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF776 135.5072842 138.3750464 132.6395219 0.958550876 -0.061073089 0.902388843 1 4.172215765 3.932358523 284309 zinc finger protein 776 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF777 254.7887735 292.356301 217.2212461 0.743001759 -0.428562468 0.198058988 1 4.504191241 3.29062083 27153 zinc finger protein 777 "GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF778 233.3760006 260.1034707 206.6485305 0.794485864 -0.331906545 0.335437984 1 1.805338039 1.410314223 197320 zinc finger protein 778 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF780A 225.6571848 234.0931236 217.2212461 0.927926642 -0.107917339 0.766395494 1 1.57900907 1.440686369 284323 zinc finger protein 780A "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF780B 105.0377571 120.6880104 89.38750391 0.740649412 -0.433137294 0.349838593 1 0.682153919 0.496782443 163131 zinc finger protein 780B "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF782 73.01767015 74.90979955 71.12554074 0.94948246 -0.074786746 0.913113947 1 0.531057163 0.495791864 158431 zinc finger protein 782 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF783 261.2394625 285.0734038 237.4055211 0.832787338 -0.263979961 0.427027208 1 3.349591286 2.742818752 100289678 zinc finger family member 783 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II hsa05168 Herpes simplex virus 1 infection ZNF784 33.18441819 38.49531366 27.87352272 0.72407574 -0.46578748 0.522230997 1 1.033932631 0.736117966 147808 zinc finger protein 784 "GO:0000978,GO:0001228,GO:0002244,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|hematopoietic progenitor cell differentiation|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 ZNF785 265.3218601 291.3158871 239.327833 0.821540615 -0.283596195 0.390359507 1 2.579129642 2.083403503 146540 zinc finger protein 785 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF786 90.93744951 129.0113214 52.86357758 0.409759213 -1.287151707 0.008279428 0.563289439 2.145558465 0.864450757 136051 zinc finger protein 786 "GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF787 384.7870174 387.0339643 382.5400705 0.98838889 -0.0168493 0.963838454 1 3.886226028 3.77682698 126208 zinc finger protein 787 "GO:0000981,GO:0005634,GO:0006357,GO:0043565,GO:0046872,GO:1990837" "DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|metal ion binding|sequence-specific double-stranded DNA binding" ZNF789 130.3794423 142.5367019 118.2221826 0.829415729 -0.269832688 0.534855266 1 1.934618975 1.577752543 285989 zinc finger protein 789 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding" ZNF79 77.77376013 98.83931885 56.7082014 0.573741321 -0.801527669 0.116832148 1 2.411921714 1.360662812 7633 zinc finger protein 79 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0003674,GO:0005515,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF790 56.48993491 44.73779695 68.24207288 1.525378484 0.609167255 0.292584108 1 0.55447608 0.8316328 388536 zinc finger protein 790 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF791 549.8573928 506.6815608 593.0332248 1.170425906 0.227033607 0.397960377 1 5.769290305 6.63953244 163049 zinc finger protein 791 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF792 89.39191994 88.43518002 90.34865986 1.021637089 0.030882806 0.97522105 1 1.16018265 1.165451475 126375 zinc finger protein 792 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0042802,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|identical protein binding|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF793 3.081612685 5.202069413 0.961155956 0.184764154 -2.436243205 0.338470402 1 0.038030806 0.006909147 390927 zinc finger protein 793 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF799 83.82815944 81.15228285 86.50403604 1.065947044 0.092135768 0.876692893 1 1.289740376 1.351789611 90576 zinc finger protein 799 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF8 220.4997748 212.2444321 228.7551175 1.0777909 0.108077311 0.768388268 1 1.243369402 1.317667598 7554 zinc finger protein 8 "GO:0000122,GO:0000978,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0008270,GO:0030509" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding|BMP signaling pathway" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF800 1398.838807 1599.116138 1198.561477 0.749514966 -0.41597081 0.082446779 1 3.358462446 2.475095633 168850 zinc finger protein 800 "GO:0003677,GO:0005634,GO:0046872" DNA binding|nucleus|metal ion binding ZNF804A 466.465152 436.9738307 495.9564733 1.134979805 0.182666628 0.514224546 1 5.151422625 5.748923026 91752 zinc finger protein 804A "GO:0003674,GO:0005634,GO:0005737,GO:0005886,GO:0010628,GO:0010975,GO:0010976,GO:0030426,GO:0043025,GO:0043197,GO:0043198,GO:0046872,GO:0098793,GO:0098794,GO:1901588,GO:1902952" molecular_function|nucleus|cytoplasm|plasma membrane|positive regulation of gene expression|regulation of neuron projection development|positive regulation of neuron projection development|growth cone|neuronal cell body|dendritic spine|dendritic shaft|metal ion binding|presynapse|postsynapse|dendritic microtubule|positive regulation of dendritic spine maintenance ZNF805 155.0424046 159.183324 150.9014851 0.947972949 -0.077082204 0.862799023 1 0.835413653 0.778697341 390980 zinc finger protein 805 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF808 189.752845 187.2744989 192.2311912 1.026467524 0.037687984 0.934222777 1 2.372862253 2.394908469 388558 zinc finger protein 808 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF81 241.2979916 278.8309205 203.7650627 0.730783596 -0.452483846 0.182220271 1 1.544120967 1.109535721 347344 zinc finger protein 81 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF813 177.9711389 206.0019488 149.9403291 0.72785879 -0.458269511 0.228576744 1 1.786761806 1.278748007 126017 zinc finger protein 813 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF814 33.3083355 29.13158871 37.48508228 1.286750361 0.363732187 0.62735858 1 0.256847736 0.324968466 730051 zinc finger protein 814 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF816 118.607797 136.2942186 100.9213754 0.740467031 -0.433492594 0.328226598 1 2.673198071 1.946292208 125893 zinc finger protein 816 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF816-ZNF321P 46.55631323 48.89945248 44.21317398 0.904165011 -0.145342006 0.845325465 1 0.984782606 0.875506237 100529240 ZNF816-ZNF321P readthrough ZNF821 169.2169397 165.4258073 173.0080721 1.045834836 0.064655031 0.882646309 1 3.334014841 3.428481505 55565 zinc finger protein 821 "GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding ZNF823 132.7131351 115.485941 149.9403291 1.298342706 0.376671243 0.378607762 1 2.342558881 2.990549787 55552 zinc finger protein 823 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF827 652.7193587 759.5021343 545.936583 0.718808491 -0.476320644 0.065816972 1 2.59031397 1.830782637 152485 zinc finger protein 827 "GO:0003677,GO:0005515,GO:0005634,GO:0010468,GO:0045944,GO:0046872" DNA binding|protein binding|nucleus|regulation of gene expression|positive regulation of transcription by RNA polymerase II|metal ion binding ZNF829 58.0901847 48.89945248 67.28091692 1.375903277 0.460379055 0.426439191 1 0.488428581 0.660784964 374899 zinc finger protein 829 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF83 1019.106633 991.5144302 1046.698836 1.055656685 0.078140725 0.753272405 1 15.45875046 16.04605466 55769 zinc finger protein 83 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF830 222.6548301 230.9718819 214.3377782 0.927982127 -0.107831076 0.767856814 1 5.507839513 5.025648006 91603 zinc finger protein 830 "GO:0001541,GO:0001546,GO:0001832,GO:0003676,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005694,GO:0006283,GO:0006397,GO:0008270,GO:0008380,GO:0016607,GO:0033260,GO:0033314,GO:0043066,GO:0044773,GO:0048478,GO:0051276,GO:0051301,GO:0060729" ovarian follicle development|preantral ovarian follicle growth|blastocyst growth|nucleic acid binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|chromosome|transcription-coupled nucleotide-excision repair|mRNA processing|zinc ion binding|RNA splicing|nuclear speck|nuclear DNA replication|mitotic DNA replication checkpoint|negative regulation of apoptotic process|mitotic DNA damage checkpoint|replication fork protection|chromosome organization|cell division|intestinal epithelial structure maintenance ZNF836 129.5818326 134.2133909 124.9502743 0.930982173 -0.103174552 0.825469957 1 1.680206896 1.538067184 162962 zinc finger protein 836 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF837 9.84933334 6.242483296 13.45618338 2.155581801 1.108077311 0.361415517 1 0.119451366 0.253178492 116412 zinc finger protein 837 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0042802,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|identical protein binding|metal ion binding" ZNF839 406.848945 398.4785171 415.219373 1.042011941 0.05937181 0.844608414 1 3.162710601 3.240435107 55778 zinc finger protein 839 GO:0046872 metal ion binding ZNF84 539.9042639 459.8629361 619.9455916 1.348109497 0.430937681 0.108725798 1 3.17326606 4.206325081 7637 zinc finger protein 84 "GO:0000978,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF841 463.7798289 442.1759001 485.3837578 1.097716446 0.134505437 0.633561756 1 4.344277449 4.688985648 284371 zinc finger protein 841 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF843 3.002354758 3.121241648 2.883467868 0.923820772 -0.11431511 1 1 0.086622429 0.078684512 283933 zinc finger protein 843 "GO:0005515,GO:0046872" protein binding|metal ion binding ZNF844 173.4131938 187.2744989 159.5518887 0.851968045 -0.231128775 0.554155265 1 1.538561547 1.288870722 284391 zinc finger protein 844 "GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF845 257.8011891 270.5076095 245.0947688 0.906054988 -0.142329486 0.675447937 1 2.219974465 1.977760565 91664 zinc finger protein 845 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF846 79.83005018 64.50566072 95.15443964 1.475133168 0.5608452 0.271256448 1 1.427850915 2.071024664 162993 zinc finger protein 846 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF85 129.9485541 118.6071826 141.2899255 1.191242574 0.252467221 0.563464669 1 1.449804706 1.698168927 7639 zinc finger protein 85 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0005634,GO:0005654,GO:0006355,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription, DNA-templated|metal ion binding" hsa05168 Herpes simplex virus 1 infection zf-C2H2 ZNF850 82.23294007 64.50566072 99.96021942 1.549634843 0.631928298 0.209196149 1 0.446388558 0.680163943 342892 zinc finger protein 850 "GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF852 75.53944693 78.0310412 73.04785266 0.936138382 -0.095206287 0.878725321 1 1.91026296 1.758346192 285346 zinc finger protein 852 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF853 90.67513802 84.27352449 97.07675156 1.151924666 0.20404637 0.68926376 1 1.139478874 1.290629341 54753 zinc finger protein 853 "GO:0000978,GO:0000981,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF860 65.7643411 86.35435226 45.17432993 0.523127425 -0.93476569 0.085064368 1 0.950417213 0.48886952 344787 zinc finger protein 860 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF862 66.57201162 69.70773014 63.4362931 0.910032402 -0.136010181 0.826055948 1 0.378797825 0.338949901 643641 zinc finger protein 862 "GO:0003674,GO:0005575,GO:0005634,GO:0006355,GO:0008150,GO:0046872,GO:0046983" "molecular_function|cellular_component|nucleus|regulation of transcription, DNA-templated|biological_process|metal ion binding|protein dimerization activity" ZNF865 236.3538176 224.7293987 247.9782366 1.103452588 0.142024643 0.686248264 1 3.187189734 3.45806199 100507290 zinc finger protein 865 "GO:0000978,GO:0003700,GO:0005634,GO:0006357,GO:0046872" RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|metal ion binding ZNF875 458.5777595 431.7717613 485.3837578 1.124167445 0.168856941 0.548840004 1 4.381605883 4.843234463 284459 zinc finger protein 875 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006355,GO:0006357,GO:0007275,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF878 19.01491347 19.76786377 18.26196316 0.923820772 -0.11431511 0.961214943 1 0.551188379 0.500678514 729747 zinc finger protein 878 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF880 59.76969242 55.14193578 64.39744905 1.1678489 0.223853626 0.711867871 1 0.53760025 0.617329877 400713 zinc finger protein 880 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF883 215.0549012 208.0827765 222.0270258 1.067012991 0.093577742 0.802824667 1 4.667925743 4.897391516 169834 zinc finger protein 883 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZNF888 217.3980404 256.982229 177.8138519 0.691930538 -0.531300881 0.131219591 1 3.00562552 2.044883385 388559 zinc finger protein 888 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF891 358.4049184 363.104445 353.7053918 0.974114739 -0.03783638 0.908648106 1 1.078845166 1.033333272 101060200 zinc finger protein 891 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNF90 111.6519924 105.0818021 118.2221826 1.125049059 0.169987913 0.720540116 1 1.497869297 1.656977297 7643 zinc finger protein 90 "GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0006355,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding" hsa05168 Herpes simplex virus 1 infection ZNF91 454.4356113 474.4287305 434.4424921 0.915717081 -0.127026162 0.654639342 1 3.717426132 3.347147424 7644 zinc finger protein 91 "GO:0000978,GO:0001228,GO:0003700,GO:0005634,GO:0006357,GO:0008270,GO:0045892,GO:0045944,GO:0070895" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of transposon integration" hsa05168 Herpes simplex virus 1 infection ZNF92 202.0497276 182.0724295 222.0270258 1.219443419 0.28622282 0.433501954 1 2.956151787 3.544537394 168374 zinc finger protein 92 "GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0008270" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|zinc ion binding" zf-C2H2 ZNF93 243.1114775 250.7397457 235.4832092 0.939153897 -0.090566507 0.799363162 1 4.843112338 4.472316044 81931 zinc finger protein 93 "GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0006357,GO:0008270,GO:0045892,GO:0070895" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding|negative regulation of transcription, DNA-templated|negative regulation of transposon integration" hsa05168 Herpes simplex virus 1 infection ZNF99 13.04983291 14.56579436 11.53387147 0.791846376 -0.336707531 0.803835859 1 0.098886869 0.07699291 7652 zinc finger protein 99 "GO:0000978,GO:0001228,GO:0003677,GO:0005634,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZNFX1 1912.82523 2274.344747 1551.305713 0.682089078 -0.551967932 0.019894144 0.808454303 16.83695368 11.29212798 57169 zinc finger NFX1-type containing 1 "GO:0003700,GO:0003723,GO:0004386,GO:0008270,GO:0031048,GO:0031380" DNA-binding transcription factor activity|RNA binding|helicase activity|zinc ion binding|heterochromatin assembly by small RNA|nuclear RNA-directed RNA polymerase complex ZNHIT1 985.3334253 824.0077951 1146.659056 1.391563359 0.476706598 0.052883744 1 45.14967306 61.77727867 10467 zinc finger HIT-type containing 1 "GO:0000812,GO:0005515,GO:0005634,GO:0005654,GO:0031063,GO:0031491,GO:0042826,GO:0043486,GO:0046872" Swr1 complex|protein binding|nucleus|nucleoplasm|regulation of histone deacetylation|nucleosome binding|histone deacetylase binding|histone exchange|metal ion binding ZNHIT2 120.7332841 129.0113214 112.4552469 0.871669599 -0.198146701 0.663122616 1 5.300305707 4.542803977 741 zinc finger HIT-type containing 2 "GO:0005515,GO:0046872" protein binding|metal ion binding ZNHIT3 533.1755578 560.7830827 505.5680329 0.90153938 -0.149537583 0.582351816 1 11.4578723 10.15686917 9326 zinc finger HIT-type containing 3 "GO:0000463,GO:0000492,GO:0005515,GO:0005634,GO:0005737,GO:0006355,GO:0046872,GO:0046966,GO:0048254,GO:0070761" "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|box C/D snoRNP assembly|protein binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|metal ion binding|thyroid hormone receptor binding|snoRNA localization|pre-snoRNP complex" ZNHIT6 733.8080892 781.3508259 686.2653526 0.8783063 -0.187203943 0.463607375 1 6.635782545 5.730721748 54680 zinc finger HIT-type containing 6 "GO:0000463,GO:0000492,GO:0001094,GO:0005515,GO:0005634,GO:0019899,GO:0042802,GO:0046872,GO:0048254,GO:0051117,GO:0051259,GO:0070062,GO:0070761" "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|box C/D snoRNP assembly|TFIID-class transcription factor complex binding|protein binding|nucleus|enzyme binding|identical protein binding|metal ion binding|snoRNA localization|ATPase binding|protein complex oligomerization|extracellular exosome|pre-snoRNP complex" ZNRD2 349.5614004 345.417409 353.7053918 1.023994108 0.034207415 0.91932257 1 23.97177148 24.13619276 10534 zinc ribbon domain containing 2 "GO:0000278,GO:0005515,GO:0051301" mitotic cell cycle|protein binding|cell division ZNRF1 776.9512812 753.259651 800.6429113 1.062904286 0.088011688 0.731293747 1 7.302467419 7.631940305 84937 zinc and ring finger 1 "GO:0000209,GO:0004842,GO:0005515,GO:0005764,GO:0005768,GO:0005829,GO:0016020,GO:0030672,GO:0043161,GO:0046872,GO:0061630,GO:0070936" protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|lysosome|endosome|cytosol|membrane|synaptic vesicle membrane|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity|protein K48-linked ubiquitination ZNRF2 232.979711 249.6993318 216.2600901 0.866081974 -0.207424514 0.551662764 1 4.207765839 3.583288216 223082 zinc and ring finger 2 "GO:0000209,GO:0001650,GO:0005654,GO:0005737,GO:0005765,GO:0005829,GO:0005886,GO:0010008,GO:0030659,GO:0032991,GO:0042734,GO:0042995,GO:0043231,GO:0046872,GO:0061630" protein polyubiquitination|fibrillar center|nucleoplasm|cytoplasm|lysosomal membrane|cytosol|plasma membrane|endosome membrane|cytoplasmic vesicle membrane|protein-containing complex|presynaptic membrane|cell projection|intracellular membrane-bounded organelle|metal ion binding|ubiquitin protein ligase activity ZNRF3 266.213819 264.2651262 268.1625117 1.014748013 0.021121515 0.961312689 1 1.635739282 1.632087623 84133 zinc and ring finger 3 "GO:0004842,GO:0005109,GO:0005515,GO:0005886,GO:0005887,GO:0006511,GO:0016055,GO:0016567,GO:0038018,GO:0046872,GO:0060173,GO:0061630,GO:0072089,GO:0090090,GO:2000051,GO:2000095" "ubiquitin-protein transferase activity|frizzled binding|protein binding|plasma membrane|integral component of plasma membrane|ubiquitin-dependent protein catabolic process|Wnt signaling pathway|protein ubiquitination|Wnt receptor catabolic process|metal ion binding|limb development|ubiquitin protein ligase activity|stem cell proliferation|negative regulation of canonical Wnt signaling pathway|negative regulation of non-canonical Wnt signaling pathway|regulation of Wnt signaling pathway, planar cell polarity pathway" hsa04310 Wnt signaling pathway ZP1 8.367970443 5.202069413 11.53387147 2.217169852 1.148719296 0.387101353 1 0.113687504 0.247846547 22917 zona pellucida glycoprotein 1 "GO:0005515,GO:0005576,GO:0005886,GO:0007339,GO:0016021,GO:0035805,GO:0062023" protein binding|extracellular region|plasma membrane|binding of sperm to zona pellucida|integral component of membrane|egg coat|collagen-containing extracellular matrix ZP3 81.42526955 81.15228285 81.69825626 1.006727764 0.009673607 1 1 2.742842422 2.715089076 7784 zona pellucida glycoprotein 3 "GO:0001809,GO:0001825,GO:0002455,GO:0002687,GO:0002922,GO:0005201,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0007339,GO:0016021,GO:0030246,GO:0031012,GO:0032190,GO:0032729,GO:0032753,GO:0035803,GO:0035804,GO:0035805,GO:0042102,GO:0042802,GO:0045892,GO:0045893,GO:0048015,GO:0048018,GO:0048599,GO:0050729,GO:0062023,GO:2000344,GO:2000360,GO:2000368,GO:2000386,GO:2000388" "positive regulation of type IV hypersensitivity|blastocyst formation|humoral immune response mediated by circulating immunoglobulin|positive regulation of leukocyte migration|positive regulation of humoral immune response|extracellular matrix structural constituent|protein binding|extracellular region|extracellular space|plasma membrane|binding of sperm to zona pellucida|integral component of membrane|carbohydrate binding|extracellular matrix|acrosin binding|positive regulation of interferon-gamma production|positive regulation of interleukin-4 production|egg coat formation|structural constituent of egg coat|egg coat|positive regulation of T cell proliferation|identical protein binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|phosphatidylinositol-mediated signaling|receptor ligand activity|oocyte development|positive regulation of inflammatory response|collagen-containing extracellular matrix|positive regulation of acrosome reaction|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosomal vesicle exocytosis|positive regulation of ovarian follicle development|positive regulation of antral ovarian follicle growth" ZPR1 1101.314421 1118.444924 1084.183918 0.969367284 -0.044884702 0.857402738 1 9.128207673 8.70051678 8882 ZPR1 zinc finger "GO:0000226,GO:0001833,GO:0001834,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006397,GO:0007165,GO:0008270,GO:0008283,GO:0008380,GO:0010628,GO:0015030,GO:0021510,GO:0030424,GO:0030426,GO:0030576,GO:0030971,GO:0031369,GO:0031641,GO:0033120,GO:0042023,GO:0042307,GO:0043025,GO:0043204,GO:0045927,GO:0048471,GO:0061564,GO:0071364,GO:0071931,GO:0097504,GO:1902742,GO:1990261,GO:2000672" microtubule cytoskeleton organization|inner cell mass cell proliferation|trophectodermal cell proliferation|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mRNA processing|signal transduction|zinc ion binding|cell population proliferation|RNA splicing|positive regulation of gene expression|Cajal body|spinal cord development|axon|growth cone|Cajal body organization|receptor tyrosine kinase binding|translation initiation factor binding|regulation of myelination|positive regulation of RNA splicing|DNA endoreduplication|positive regulation of protein import into nucleus|neuronal cell body|perikaryon|positive regulation of growth|perinuclear region of cytoplasm|axon development|cellular response to epidermal growth factor stimulus|positive regulation of transcription involved in G1/S transition of mitotic cell cycle|Gemini of coiled bodies|apoptotic process involved in development|pre-mRNA catabolic process|negative regulation of motor neuron apoptotic process ZRANB1 936.1748486 971.7465664 900.6031308 0.926788076 -0.109688612 0.660084387 1 7.678461394 6.997224712 54764 zinc finger RANBP2-type containing 1 "GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007010,GO:0008234,GO:0016055,GO:0016477,GO:0016579,GO:0018215,GO:0022604,GO:0030177,GO:0035523,GO:0043231,GO:0046872,GO:0070530,GO:0070536,GO:0071947,GO:1990168" thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton organization|cysteine-type peptidase activity|Wnt signaling pathway|cell migration|protein deubiquitination|protein phosphopantetheinylation|regulation of cell morphogenesis|positive regulation of Wnt signaling pathway|protein K29-linked deubiquitination|intracellular membrane-bounded organelle|metal ion binding|K63-linked polyubiquitin modification-dependent protein binding|protein K63-linked deubiquitination|protein deubiquitination involved in ubiquitin-dependent protein catabolic process|protein K33-linked deubiquitination ZRANB2 3445.50176 3185.747309 3705.25621 1.163072853 0.217941467 0.35847515 1 58.80922819 67.25484519 9406 zinc finger RANBP2-type containing 2 "GO:0001530,GO:0003723,GO:0005515,GO:0005654,GO:0006397,GO:0008380,GO:0046872" lipopolysaccharide binding|RNA binding|protein binding|nucleoplasm|mRNA processing|RNA splicing|metal ion binding ZRANB3 208.4802949 224.7293987 192.2311912 0.855389603 -0.225346422 0.534677254 1 1.484331061 1.248434959 84083 zinc finger RANBP2-type containing 3 "GO:0000733,GO:0003678,GO:0004520,GO:0005515,GO:0005524,GO:0005654,GO:0006281,GO:0006974,GO:0009411,GO:0031297,GO:0032508,GO:0036292,GO:0036310,GO:0043596,GO:0045910,GO:0046872,GO:0048478,GO:0070530,GO:0090305" DNA strand renaturation|DNA helicase activity|endodeoxyribonuclease activity|protein binding|ATP binding|nucleoplasm|DNA repair|cellular response to DNA damage stimulus|response to UV|replication fork processing|DNA duplex unwinding|DNA rewinding|annealing helicase activity|nuclear replication fork|negative regulation of DNA recombination|metal ion binding|replication fork protection|K63-linked polyubiquitin modification-dependent protein binding|nucleic acid phosphodiester bond hydrolysis ZRSR2 247.4071111 224.7293987 270.0848236 1.201822393 0.265223708 0.433976136 1 2.799578658 3.308294359 8233 "zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2" "GO:0000245,GO:0000398,GO:0005515,GO:0005654,GO:0005681,GO:0005689,GO:0008380,GO:0030628,GO:0042802,GO:0046872,GO:0089701" "spliceosomal complex assembly|mRNA splicing, via spliceosome|protein binding|nucleoplasm|spliceosomal complex|U12-type spliceosomal complex|RNA splicing|pre-mRNA 3'-splice site binding|identical protein binding|metal ion binding|U2AF complex" ZSCAN12 39.98673739 53.06110801 26.91236677 0.507195718 -0.97938553 0.133138534 1 0.239331796 0.119356797 9753 zinc finger and SCAN domain containing 12 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZSCAN16 99.8753167 111.3242854 88.42634795 0.794313187 -0.33222014 0.485490696 1 1.973811465 1.541589056 80345 zinc finger and SCAN domain containing 16 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 ZSCAN2 217.6062461 237.2143652 197.9981269 0.834680171 -0.260704597 0.463344569 1 2.737823246 2.246966935 54993 zinc finger and SCAN domain containing 2 "GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0007275,GO:0007283,GO:0030154,GO:0046872" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|spermatogenesis|cell differentiation|metal ion binding" zf-C2H2 ZSCAN20 122.5266483 150.860013 94.19328369 0.624375418 -0.679514356 0.118820337 1 0.607585965 0.373013636 7579 zinc finger and SCAN domain containing 20 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZSCAN21 198.9133947 213.2848459 184.5419436 0.865237015 -0.208832709 0.573266094 1 3.586206751 3.050995682 7589 zinc finger and SCAN domain containing 21 "GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0045944,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding" ZSCAN22 72.49746321 73.86938567 71.12554074 0.962855452 -0.054608864 0.945243683 1 0.670340647 0.634640564 342945 zinc finger and SCAN domain containing 22 "GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005634,GO:0006357,GO:0008150,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding" zf-C2H2 ZSCAN25 265.7577787 302.7604398 228.7551175 0.755564755 -0.40437269 0.21824568 1 1.794908712 1.333476097 221785 zinc finger and SCAN domain containing 25 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZSCAN26 281.6910795 317.3262342 246.0559247 0.775403664 -0.366980542 0.255331385 1 5.628154835 4.291064714 7741 zinc finger and SCAN domain containing 26 "GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" ZSCAN29 315.3214771 342.2961674 288.3467868 0.842389761 -0.247440193 0.427360904 1 2.879980662 2.38546929 146050 zinc finger and SCAN domain containing 29 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 ZSCAN30 409.0731974 444.2567279 373.8896669 0.841607214 -0.248781025 0.388635678 1 5.302877445 4.388258655 100101467 zinc finger and SCAN domain containing 30 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" ZSCAN31 44.47045505 57.22276355 31.71814655 0.554292463 -0.851280704 0.174677771 1 0.64632248 0.352256823 64288 zinc finger and SCAN domain containing 31 "GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" other ZSCAN32 369.2795744 408.8826559 329.6764929 0.806286322 -0.310635846 0.294454902 1 6.964990696 5.521804315 54925 zinc finger and SCAN domain containing 32 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding" hsa05168 Herpes simplex virus 1 infection ZSCAN5A 84.59117058 75.95021343 93.23212773 1.227542669 0.295773173 0.563005852 1 1.212118212 1.463028385 79149 zinc finger and SCAN domain containing 5A "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" zf-C2H2 ZSCAN9 250.5579209 256.982229 244.1336128 0.950001927 -0.073997655 0.835978348 1 4.642745176 4.336811164 7746 zinc finger and SCAN domain containing 9 "GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding" ZSWIM1 309.5595718 329.8112008 289.3079428 0.877192594 -0.189034463 0.548858759 1 8.314321029 7.171217988 90204 zinc finger SWIM-type containing 1 "GO:0005634,GO:0008270" nucleus|zinc ion binding ZSWIM3 92.55279056 95.7180772 89.38750391 0.933862302 -0.098718255 0.858534134 1 1.840164934 1.68970455 140831 zinc finger SWIM-type containing 3 "GO:0005515,GO:0008270" protein binding|zinc ion binding ZSWIM4 399.3477814 428.6505196 370.0450431 0.863279119 -0.212101002 0.466379665 1 4.565214609 3.875106238 65249 zinc finger SWIM-type containing 4 "GO:0008270,GO:0031462,GO:1902667" zinc ion binding|Cul2-RING ubiquitin ligase complex|regulation of axon guidance ZSWIM5 26.21855272 32.25283036 20.18427508 0.625814071 -0.676193998 0.387573448 1 0.289874415 0.178371879 57643 zinc finger SWIM-type containing 5 "GO:0005615,GO:0008270,GO:0031462,GO:1902667" extracellular space|zinc ion binding|Cul2-RING ubiquitin ligase complex|regulation of axon guidance ZSWIM6 844.7813588 881.2305586 808.332159 0.917276587 -0.124571279 0.620942665 1 6.636045616 5.985230077 57688 zinc finger SWIM-type containing 6 "GO:0008270,GO:0021773,GO:0031462,GO:1902667" zinc ion binding|striatal medium spiny neuron differentiation|Cul2-RING ubiquitin ligase complex|regulation of axon guidance ZSWIM7 200.9149646 215.3656737 186.4642555 0.865803042 -0.207889225 0.573508527 1 5.689935733 4.843927643 125150 zinc finger SWIM-type containing 7 "GO:0000724,GO:0005515,GO:0005634,GO:0008270,GO:0050821,GO:0097196" double-strand break repair via homologous recombination|protein binding|nucleus|zinc ion binding|protein stabilization|Shu complex ZSWIM8 2311.803717 2327.405855 2296.201579 0.986592679 -0.019473513 0.93624837 1 20.78122351 20.15951969 23053 zinc finger SWIM-type containing 8 "GO:0008270,GO:0031462,GO:1902667" zinc ion binding|Cul2-RING ubiquitin ligase complex|regulation of axon guidance ZSWIM9 186.3837688 199.7594655 173.0080721 0.866081974 -0.207424514 0.585993768 1 2.3738133 2.021513922 374920 zinc finger SWIM-type containing 9 GO:0005515 protein binding ZUP1 343.1855534 266.345954 420.0251528 1.576990927 0.65717436 0.029721213 0.891465488 5.492424281 8.51656473 221302 zinc finger containing ubiquitin peptidase 1 "GO:0004843,GO:0005515,GO:0005634,GO:0005737,GO:0006508,GO:0010468,GO:0018215,GO:0046872" thiol-dependent ubiquitin-specific protease activity|protein binding|nucleus|cytoplasm|proteolysis|regulation of gene expression|protein phosphopantetheinylation|metal ion binding ZW10 1030.729823 968.6253247 1092.834322 1.128232242 0.174064071 0.479050285 1 17.8685632 19.82254068 9183 zw10 kinetochore protein "GO:0000070,GO:0000132,GO:0000776,GO:0000777,GO:0000922,GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0005811,GO:0005828,GO:0005829,GO:0006888,GO:0006890,GO:0007030,GO:0007080,GO:0007094,GO:0007096,GO:0015031,GO:0016020,GO:0019237,GO:0034501,GO:0051301,GO:0051321,GO:0065003,GO:0070939,GO:0072413,GO:1990423" "mitotic sister chromatid segregation|establishment of mitotic spindle orientation|kinetochore|condensed chromosome kinetochore|spindle pole|protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|kinetochore microtubule|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|mitotic metaphase plate congression|mitotic spindle assembly checkpoint|regulation of exit from mitosis|protein transport|membrane|centromeric DNA binding|protein localization to kinetochore|cell division|meiotic cell cycle|protein-containing complex assembly|Dsl1/NZR complex|signal transduction involved in mitotic cell cycle checkpoint|RZZ complex" ZWILCH 1043.343123 1072.666713 1014.019534 0.945325814 -0.081116444 0.743404048 1 15.51388916 14.4202696 55055 zwilch kinetochore protein "GO:0000776,GO:0000777,GO:0005515,GO:0005829,GO:0034501,GO:0051301,GO:0072413,GO:1990423" kinetochore|condensed chromosome kinetochore|protein binding|cytosol|protein localization to kinetochore|cell division|signal transduction involved in mitotic cell cycle checkpoint|RZZ complex ZWINT 2876.896181 2792.470861 2961.3215 1.060466393 0.084698901 0.721322369 1 69.50981227 72.47933566 11130 ZW10 interacting kinetochore protein "GO:0000070,GO:0000776,GO:0000777,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0007093,GO:0007094,GO:0016604,GO:0030425,GO:0047485,GO:0051301,GO:0051649" mitotic sister chromatid segregation|kinetochore|condensed chromosome kinetochore|protein binding|nucleoplasm|cytoplasm|cytosol|mitotic cell cycle checkpoint|mitotic spindle assembly checkpoint|nuclear body|dendrite|protein N-terminus binding|cell division|establishment of localization in cell ZXDA 105.1220455 110.2838716 99.96021942 0.906390191 -0.141795846 0.774625441 1 1.170341526 1.043035261 7789 zinc finger X-linked duplicated A "GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0006357,GO:0045893,GO:0046872,GO:0070742" "transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription, DNA-templated|metal ion binding|C2H2 zinc finger domain binding" ZXDB 499.3916747 519.1665274 479.616822 0.923820772 -0.11431511 0.680732275 1 5.068037933 4.603612476 158586 zinc finger X-linked duplicated B "GO:0003674,GO:0003712,GO:0005515,GO:0005634,GO:0006357,GO:0008150,GO:0046872" molecular_function|transcription coregulator activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding ZXDC 700.117941 805.2803452 594.9555368 0.738817904 -0.436709267 0.088118877 1 6.955224467 5.052656108 79364 ZXD family zinc finger C "GO:0003712,GO:0003713,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0030275,GO:0045893,GO:0046872,GO:0070742" "transcription coregulator activity|transcription coactivator activity|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|LRR domain binding|positive regulation of transcription, DNA-templated|metal ion binding|C2H2 zinc finger domain binding" zf-C2H2 ZYG11B 1289.972132 1340.053081 1239.891183 0.925255276 -0.112076638 0.64343042 1 8.994613258 8.183050729 79699 "zyg-11 family member B, cell cycle regulator" "GO:0005515,GO:0006515,GO:0031462,GO:0032436" protein binding|protein quality control for misfolded or incompletely synthesized proteins|Cul2-RING ubiquitin ligase complex|positive regulation of proteasomal ubiquitin-dependent protein catabolic process ZYX 3371.085172 3402.153396 3340.016947 0.981736141 -0.026592768 0.911956384 1 81.49312112 78.66597125 7791 zyxin "GO:0001725,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0005925,GO:0007160,GO:0007165,GO:0007179,GO:0007229,GO:0007267,GO:0015629,GO:0016032,GO:0043149,GO:0045335,GO:0046872,GO:0050727,GO:0071346" stress fiber|RNA binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|adherens junction|focal adhesion|cell-matrix adhesion|signal transduction|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|cell-cell signaling|actin cytoskeleton|viral process|stress fiber assembly|phagocytic vesicle|metal ion binding|regulation of inflammatory response|cellular response to interferon-gamma hsa04510 Focal adhesion ZZEF1 1238.242703 1407.679983 1068.805423 0.759267331 -0.397320161 0.099918351 1 5.621047026 4.196460222 23140 zinc finger ZZ-type and EF-hand domain containing 1 "GO:0005509,GO:0008270" calcium ion binding|zinc ion binding ZZZ3 1595.79652 1597.03531 1594.557731 0.998448639 -0.002239879 0.99550413 1 11.45729792 11.24809858 26009 zinc finger ZZ-type containing 3 "GO:0003677,GO:0005515,GO:0005654,GO:0005671,GO:0005730,GO:0008270,GO:0043967" DNA binding|protein binding|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|nucleolus|zinc ion binding|histone H4 acetylation MYB